bluuebunny/crossref_metadata_2025 huggingface dataset:
The Hardest Part Is Knowing I Will Survive: The Use of Music and Creative Mediums to Enhance Empathy and Facilitate Life-Long Distance Learning in Professionally Qualified Clinicians
Authors: Keville Saskia , Nutt Katherine , Brunton Isabel , Keyes Carly , Tacconelli Erasmo
Published: August 2019

Music is an experience that can cross personal and professional domains alongside cultural, gender, age and generational boundaries; it can also enhance the learning process through emotional processing and connection. This paper focuses on the learning experience of qualified clinical psychologists (CPs) working in the United Kingdom. This group of CPs had experience of undertaking experiential learning and reflective writing during their professional training. It considers the potential to continue a learning process, 3 years post qualification, through long distance methods using vignette-based material.Empathising with, and understanding, the position of others from differing backgrounds is an important competency within the therapeutic work of CPs and this comes alongside acknowledging and understanding ones’ own experiences, both past and present. CPs work with difficult life experiences and complex issues; connecting constantly can be exhausting and, perhaps, unrealistic. Yet, to truly empathise one must connect with, and understand, the lived experiences of others. We will consider what helps and hinders this process, and how music and other creative mediums can be effectively used in learning even via long distance methods. We will further consider how CPs may be well placed to enhance the learning about, and processing of, difficult emotional experiences for themselves, other clinicians and the people they might work with.
Dynamics of drug response informs rational combination regimens
Authors: Paudel B. Bishal , Quaranta Vito
Published: August 2019

Metabolic reprogramming could be targeted to eliminate drug-tolerant cancer cells (Goldman
et al
., in 20 August 2019 issue).
Parkin protects against necroptosis
Authors: Wong Wei
Published: August 2019

Activation of Parkin by AMPK-mediated phosphorylation inhibits RIPK3 and prevents necroptosis.
Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice
Authors: Pi Ruoxi , Iwasaki Akiko , Sewald Xaver , Mothes Walther , Uchil Pradeep D.
Published: August 2019

Viruses establish infection in hosts by targeting highly permissive cell types. The retrovirus Friend murine leukemia virus (FrMLV) infects a subtype of B cells called B-1 cells that permit robust virus replication. The reason for their susceptibility had remained unknown. We found that innate sensing of incoming virus and the ensuing type I interferon response within B-1 cells are responsible for their observed susceptibility. Our data provide insights into how retroviruses coevolved with the host to co-opt innate immune sensing pathways designed to fight virus infections for establishing infection. Understanding early events in viral spread can inform antiviral intervention strategies that prevent the colonization of a host.
A Microbiome-Based Index for Assessing Skin Health and Treatment Effects for Atopic Dermatitis in Children
Authors: Sun Zheng , Huang Shi , Zhu Pengfei , Yue Feng , Zhao Helen , Yang Ming , Niu Yueqing , Jing Gongchao , Su Xiaoquan , Li Huiying , Callewaert Chris , Knight Rob , Liu Jiquan , Smith Ed , Wei Karl , Xu Jian
Published: August 2019

MiSH, which is based on the skin microbiome, can quantitatively assess pediatric skin health across cohorts from distinct countries over large geographic distances. Moreover, the index can identify a risk-prone skin state and compare treatment effect in children, suggesting applications in diagnosis and patient stratification.
Izanagi-Pacific ridge subduction revealed by a 56 to 46 Ma magmatic gap along the northeast Asian margin
Authors: Wu Jeremy Tsung-Jui , Wu Jonny
Published: August 2019

Recent studies have debated the timing and spatial configuration of a possible intersection between the Pacific-Izanagi spreading ridge and the northeast Asian continental margin during Cretaceous or early Cenozoic times. Here we examine a newly compiled magmatic catalog of ∼900 published Cretaceous to Miocene igneous rock radioisotopic values and ages from the northeast Asian margin for ridge subduction evidence. Our synthesis reveals that a near-synchronous 56–46 Ma magmatic gap occurred across ∼1500 km of the Eurasian continental margin between Japan and Sikhote-Alin, Russian Far East. The magmatic gap separated two distinct phases of igneous activity: (1) an older, Cretaceous to Paleocene pre–56 Ma episode that had relatively lower εNd(t) (−15 to + 2), elevated (87Sr/86Sr)0 (initial ratio, 0.704–0.714), and relatively higher magmatic fluxes (∼1090 km2/m.y.); and (2) a younger, late Eocene to Miocene post–46 Ma phase that had relatively elevated εNd(t) (−2 to + 10), lower (87Sr/86Sr)0 (0.702–0.707), and a lower 390 km2/m.y. magmatic flux. The 56–46 Ma magmatic gap links other geological evidence across northeast Asia to constrain an early Cenozoic, low-angle ridge-trench intersection that had profound consequences for the Eurasian continental margin, and possibly led to the ca. 53–47 Ma Pacific plate reorganization.
Ex situ liver resection and autotransplantation for advanced cholangiocarcinoma
Authors: George Ashish , Rammohan Ashwin , Reddy Srinivas Mettu , Rela Mohamed
Published: August 2019

Advanced cholangiocarcinoma especially those involving the vasculature have extremely limited options of cure. Ex situ liver resection entails performing a total hepatectomy, resecting the tumour on the back-table followed by reimplantation (autotransplantation) of the liver. Application of this technique for these tumours has rarely been done due to complexity of the procedure and the dismal prognosis of the lesions. We present our experience of two cases of advanced intrahepatic cholangiocarcinoma with limited extrahepatic disease who underwent ex situ resection with autotransplantation. They underwent preoperative therapy with a waiting period to assess the tumour biology. Both patients underwent ex situ resection with extended hepatectomy on the back table. Both patients remain well on follow-up 24 months and 20 months, respectively, with excellent quality of life. Despite its technical complexity, ex situ liver resection may offer prolonged overall survival in selected patients with advanced cholangiocarcinoma and limited extrahepatic disease.
Characterising the gut microbiome in veterans with Gulf War Illness: a protocol for a longitudinal, prospective cohort study
Authors: Keating Julie A , Shaughnessy Catherine , Baubie Kelsey , Kates Ashley E , Putman-Buehler Nathan , Watson Lauren , Dominguez Nadia , Watson Kal , Cook Dane B , Rabago David , Suen Garret , Gangnon Ronald , Safdar Nasia
Published: August 2019

Introduction

Approximately 25%–35% of the 1991 Gulf War Veteran population report symptoms consistent with Gulf War Illness (GWI), a chronic, multi-symptom illness characterised by fatigue, pain, irritable bowel syndrome and problems with cognitive function. GWI is a disabling problem for Gulf War Veterans, and there remains a critical need to identify innovative, novel therapies.

Gut microbiota perturbation plays a key role in the symptomatology of other chronic multi-symptom illnesses, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Given similarities between ME/CFS and GWI and the presence of gastrointestinal disorders in GWI patients, Veterans with GWI may also have gut abnormalities like those seen with ME/CFS. In this longitudinal cohort study, we are comparing the diversity (structure) and the metagenomes (function) of the gut microbiome between Gulf War Veterans with and without GWI. If we find differences in Veterans with GWI, the microbiome could be a target for therapeutic intervention to alleviate GWI symptoms.

Methods and analysis

Participants answer questions about diet, exercise and lifestyle factors. Participants also complete a questionnaire (based on the Kansas case definition of GWI) regarding their medical history and symptoms; we use this questionnaire to group participants into GWI versus healthy control cohorts. We plan to enrol 52 deployed Gulf War Veterans: 26 with GWI and 26 healthy controls. Participants provide stool and saliva samples weekly for an 8-week period for microbiome analyses. Participants also provide blood samples at the beginning and end of this period, which we will use to compare measures of inflammation markers between the groups.

Ethics and dissemination

The protocol was approved by the University of Wisconsin-Madison Health Sciences Institutional Review Board and the William S. Middleton Memorial Veterans Hospital Research and Development Committee. Results of this study will be submitted for publication in a peer-reviewed journal.
Forecasting annual incidence and mortality rate for prostate cancer in Australia until 2022 using autoregressive integrated moving average (ARIMA) models
Authors: Earnest Arul , Evans Sue M , Sampurno Fanny , Millar Jeremy
Published: August 2019

Objectives

Prostate cancer is the second most common cause of cancer-related death in males after lung cancer, imposing a significant burden on the healthcare system in Australia. We propose the use of autoregressive integrated moving average (ARIMA) models in conjunction with population forecasts to provide for robust annual projections of prostate cancer.

Design

Data on the incidence and mortality from prostate cancer was obtained from the Australian Institute of Health and Welfare. We formulated several ARIMA models with different autocorrelation terms and chose one which provided for an accurate fit of the data based on the mean absolute percentage error (MAPE). We also assessed the model for external validity. A similar process was used to model age-standardised incidence and mortality rate for prostate cancer in Australia during the same time period.

Results

The annual number of prostate cancer cases diagnosed in Australia increased from 3606 in 1982 to 20 065 in 2012. There were two peaks observed around 1994 and 2009. Among the various models evaluated, we found that the model with an autoregressive term of 1 (coefficient=0.45, p=0.028) as well as differencing the series provided the best fit, with a MAPE of 5.2%. External validation showed a good MAPE of 5.8% as well. We project prostate cancer incident cases in 2022 to rise to 25 283 cases (95% CI: 23 233 to 27 333).

Conclusion

Our study has accurately characterised the trend of prostate cancer incidence and mortality in Australia, and this information will prove useful for resource planning and manpower allocation.
KCNN4 Promotes Invasion and Metastasis through the MAPK/ERK Pathway in Hepatocellular Carcinoma
Authors: Li Qiu-Ting , Feng Yi-Ming , Ke Zun-Hui , Qiu Meng-Jun , He Xiao-Xiao , Wang Meng-Meng , Li Ya-Nan , Xu Jing , Shi Liang-Liang , Xiong Zhi-Fan
Published: August 2019

Hepatocellular Carcinoma (HCC) is one of the most common malignancies in the world, and is well-known for its bad prognosis. Potassium calcium-activated channel subfamily N member 4 (KCNN4) is a type of intermediate conductance calcium-activated potassium channel, and increasing evidence suggests that KCNN4 contributes to the regulation of invasion and metastasis in a number of cancers. However, its clinical significance and biological function remain unclear in the HCC disease process. In this study, the expression levels of KCNN4 in 86 HCC samples were compared with corresponding paracancerous tissues. sh-RNA was used to reduce the expression of KCNN4 in Hep3B HCC cells in vitro; this was confirmed by Real time-PCR and western blotting. Wound healing, transwell assays and high content analysis were performed to investigate the tumor-promoting characteristics of KCNN4 in Hep3B HCC cells. As results, KCNN4 expression was significantly associated with preoperative serum alpha-fetoprotein level (p=0.038) and TNM stage (p=0.039). Additionally, patients with high KCNN4 amplification in HCC tissue exhibited shorter disease-free survival, whereas there was no statistical significance between KCNN4 amplification and overall survival. Wound healing and transwell assays showed that knockdown of KCNN4 expression could reduce migration and invasion abilities of HCC cells. High content analysis result showed that down-regulated KCNN4 could inhibit the ability of HCC cell proliferation. The mitogen-activated protein kinase (MAPK) pathway is active in cell proliferation, differentiation, migration, senescence, and apoptosis. Matrix metallopeptidase 9 and extracellular signal regulated kinase 1/2 (ERK1/2) were important biomarkers of MAPK/ERK pathway, knockdown of KCNN4 reduced the expression of MMP9 and ERK1/2. These findings showed that KCNN4 promotes HCC invasion and metastasis through the MAPK/ERK pathway.
Breed and anatomical predisposition for canine cutaneous neoplasia in South Africa during 2013
Authors: Tompkins Samantha , Fosgate Geoffrey T , Williams June , Clift Sarah
Published: August 2019

Cutaneous neoplasia occurs commonly in dogs and owners in consultation with their veterinarian must decide when to perform surgery to obtain a histopathological diagnosis. The objective of this study was to identify breed predispositions for canine cutaneous neoplasms and determine factors associated with malignancy. This retrospective case‐series evaluated histopathology reports from two veterinary pathology laboratories in South Africa during a six‐month study period. Breed predispositions were analysed using log‐linear models and risk factors for malignancy were evaluated using binary logistic regression. Data were available for 2553 cutaneous neoplasms from 2271 dogs. The most frequent neoplasms were mast cell tumours (21.1per cent), histiocytoma (9.4per cent), haemangiosarcoma (8.3per cent), melanocytoma (5.8per cent) and lipoma (5.1per cent). Boxers (relative proportion (RP)=38.9; 95% CI 2.3 to 646), pugs (7.6; 1.4 to 41.0), Staffordshire bull terriers (7.0; 1.9 to 26.3), boerboels (3.8; 1.3 to 10.7), Labrador retrievers (2.7; 1.0 to 7.0) and mixed breed dogs (2.2; 1.1 to 4.4) had a higher frequency of mast cell tumours. Jack Russell terriers (OR=2.5; 95% CI 1.8 to 3.5), Rottweilers (2.3; 1.3 to 3.9), pit bull terriers (2.2; 1.1 to 4.3) and Staffordshire bull terriers (1.6; 1.0 to 2.6) were more likely to have malignant neoplasms. Dog signalment might facilitate prognosis determination for cutaneous canine neoplasia before receiving a histopathological diagnosis.
Centrifuge model study on settlement of strip footing subject to rising water table in loess
Authors: Xu Yanrong , Leung C.F. , Yu Jian , Chen Wenwu
Published: August 2019

Owing to man-made activities and natural conditions, the groundwater table experiences considerable changes in Lanzhou. Centrifugal model tests were performed to investigate the settlement of strip footings on loess subject to rising water table under different foundation pressures. The air-fall method was employed to reconstitute the artificial loess samples. The applicability of the air-fall prepared samples was evaluated against the parameters of the undisturbed loess samples obtained from the same location. The results of centrifuge tests reveal that the footing settlement increases significantly with increasing foundation loading pressure or increasing rising water table. However, the rate of increase in ultimate footing settlement under combined rising water level and footing pressure is established to be more intriguing. A simplified method for predicting the ultimate footing settlement on collapsible loess due to rising water table height is proposed. The proposed formulation is verified, as there is a good agreement between the test results under various loading pressures and rising water heights and the predicted ultimate footing settlements. A discussion on the ultimate settlement of strip footings subjected to rising water table against conventional bearing capacity safety factors is presented to provide some basis for the foundation design consideration under rising water scenario.
A blood metabolomics study of metabolic variations in Inner Mongolia white cashmere goats under shortened and natural photoperiod conditions
Authors: Zhang C.Z. , Sun H.Z. , Sang D. , Li S.L. , Zhang C.H. , Jin L.
Published: August 2019

This study investigated metabolic variations by using gas chromatography – mass spectrometry (GC–MS)-based metabolomics in the blood of Inner Mongolia white cashmere goats under shortened and natural photoperiod conditions. Twenty-four female (non-pregnant) Inner Mongolia white cashmere goats aged 1–1.5 yr with similar live weights (mean, 20.36 ± 2.63 kg) were randomly allocated into two groups: a natural daily photoperiod group (NDPP group: 10–16 h light, n = 12) and a short daily photoperiod group (SDPP group: 7 h light:17 h dark, n = 12). In this study, we found that a SDPP promoted the blood metabolic perturbations based on the GC–MS-based metabolomics investigation, and nine metabolites were related to a SDPP. Compared with the NDPP group, the contents of serine, oxaloacetic acid, xylose, l-3,4-dihydroxyphenylalanine, and xanthosine significantly were up-regulated, whereas the contents of carnitine, 1,3-diaminopropane, indole-3-acetic acid, and l-kynurenine were significantly down-regulated in the SDPP group. The different metabolites could contribute to the regulation mechanisms of promoting cashmere growth of goats in the SDPP group.
Incorporating bicycling demand into pavement management systems for convenient bikeway networks
Authors: Elsaid Feras , Amador-Jimenez Luis , Alecsandru Ciprian
Published: August 2019

Several cities around the world have announced strategies to extend and (or) upgrade their bikeway networks in response to the rapid increase of bicycle users. However, there is a disconnection between these strategies and management systems, often used for the scheduling of maintenance and rehabilitation of roads. Traditional pavement management systems fail to incorporate bicycle pathways considering bicycling demand, along with pavement condition, as a driving element to budget for improvements. More convenient and safer bicycling facilities can encourage more individuals to shift their daily commuting habits to bicycling. In this study, we incorporate bicycling demand into pavement management systems to produce strategic plans for the maintenance and improvement of the bicycle networks. Furthermore, here we employ smartphones to represent bicycling demand using GPS trajectories of bicycles. In addition, goal optimization is applied to schedule interventions and improvements. Two scenarios are investigated with different annual budgets.
Cell ultrastructure and physiological changes of potato during cold acclimation
Authors: Wu Qiaoyu , He Tianjiu , Liu Hui , Luo Xiaobo , Yin Wang , Chen Enfa , Li Fei
Published: August 2019

Potato cultivars are sensitive to frost; thus, freezing damage often results in heavy loss of potato yield. In this study, two wild potato species, Solanum acaule W3, which is frost-resistant and has cold-acclimation ability, and Solanum cardiophyllum Cph12, which is frost-sensitive and cannot be cold-acclimated, were used to research the cell structure and physiological changes that occur during cold acclimation. The results showed that the frost resistance of W3 was enhanced by cold acclimation, while the frost resistance of Cph12 did not change. The subcellular characteristics related to the enhancement of freezing resistance mainly include a decrease in the proportion of the vacuole to total cell volume, integrity of the biomembrane, and orderly arrangement of grana lamellae. At the physiological level, the W3 damage index was correlated with membrane lipid peroxidation system indices (including chlorophyll, malondialdehyde, and the difference between relative conductivity before and after freezing treatment in W3), the activity of the antioxidant enzymes superoxide dismutase and catalase, the contents of the osmotic regulators proline and soluble protein, and the contents of the endogenous hormones salicylic acid (SA), indole acetic acid/abscisic acid (IAA/ABA), and SA/ABA, which indicated that cold acclimation enhanced the freezing resistance of wild potato species W3 by enhancing its original cold-tolerance characteristics. The results could be useful to clarify the cold resistance mechanism of plants, and to provide a theoretical basis for cold-resistance breeding.
Search for the anomalous ZZH couplings at the CLIC
Authors: Şahin B.
Published: August 2019

We have investigated the potential of Higgs boson production at [Formula: see text] mode of the Compact Linear Collider (CLIC) to probe anomalous ZZH couplings. Considering two different center of mass energies of CLIC ([Formula: see text] = 1.5 and 3 TeV) and various integrated luminosities, we have calculated 95% confidence level (CL) bounds on the anomalous ZZH coupling parameters [Formula: see text], [Formula: see text] and [Formula: see text]. We perform an analysis through the process [Formula: see text] with systematic uncertainties of [Formula: see text] = 0%, 5%, 10%. Obtained results have been discussed in terms of capability to probe anomalous ZZH couplings in the photoproduction process.
Fully-Dynamic and Kinetic Conflict-Free Coloring of Intervals with Respect to Points
Authors: de Berg Mark , Leijsen Tim , Markovic Aleksandar , van Renssen André , Roeloffzen Marcel , Woeginger Gerhard
Published: August 2019

We introduce the fully-dynamic conflict-free coloring problem for a set [Formula: see text] of intervals in [Formula: see text] with respect to points, where the goal is to maintain a conflict-free coloring for [Formula: see text] under insertions and deletions. A coloring is conflict-free if for each point [Formula: see text] contained in some interval, [Formula: see text] is contained in an interval whose color is not shared with any other interval containing [Formula: see text]. We investigate trade-offs between the number of colors used and the number of intervals that are recolored upon insertion or deletion of an interval. Our results include:

a lower bound on the number of recolorings as a function of the number of colors, which implies that with [Formula: see text] recolorings per update the worst-case number of colors is [Formula: see text], and that any strategy using [Formula: see text] colors needs [Formula: see text] recolorings; a coloring strategy that uses [Formula: see text] colors at the cost of [Formula: see text] recolorings, and another strategy that uses [Formula: see text] colors at the cost of [Formula: see text] recolorings; stronger upper and lower bounds for special cases.

We also consider the kinetic setting where the intervals move continuously (but there are no insertions or deletions); here we show how to maintain a coloring with only four colors at the cost of three recolorings per event and show this is tight.
Clustering Users by Their Mobility Behavioral Patterns
Authors: Ben-Gal Irad , Weinstock Shahar , Singer Gonen , Bambos Nicholas
Published: August 2019

The immense stream of data from mobile devices during recent years enables one to learn more about human behavior and provide mobile phone users with personalized services. In this work, we identify clusters of users who share similar mobility behavioral patterns. We analyze trajectories of semantic locations to find users who have similar mobility “lifestyle,” even when they live in different areas. For this task, we propose a new grouping scheme that is called Lifestyle-Based Clustering (LBC). We represent the mobility movement of each user by a Markov model and calculate the Jensen–Shannon distances among pairs of users. The pairwise distances are represented by a similarity matrix, which is used for the clustering. To validate the unsupervised clustering task, we develop an entropy-based clustering measure, namely, an index that measures the homogeneity of mobility patterns within clusters of users. The analysis is validated on a real-world dataset that contains location-movements of 50,000 cellular phone users that were analyzed over a two-month period.
Deep Scalable Supervised Quantization by Self-Organizing Map
Authors: Wang Min , Zhou Wengang , Tian Qi , Li Houqiang
Published: August 2019

Approximate Nearest Neighbor (ANN) search is an important research topic in multimedia and computer vision fields. In this article, we propose a new deep supervised quantization method by Self-Organizing Map to address this problem. Our method integrates the Convolutional Neural Networks and Self-Organizing Map into a unified deep architecture. The overall training objective optimizes supervised quantization loss as well as classification loss. With the supervised quantization objective, we minimize the differences on the maps between similar image pairs and maximize the differences on the maps between dissimilar image pairs. By optimization, the deep architecture can simultaneously extract deep features and quantize the features into suitable nodes in self-organizing map. To make the proposed deep supervised quantization method scalable for large datasets, instead of constructing a larger self-organizing map, we propose to divide the input space into several subspaces and construct self-organizing map in each subspace. The self-organizing maps in all the subspaces implicitly construct a large self-organizing map, which costs less memory and training time than directly constructing a self-organizing map with equal size. The experiments on several public standard datasets prove the superiority of our approaches over the existing ANN search methods. Besides, as a by-product, our deep architecture can be directly applied to visualization with little modification, and promising performance is demonstrated in the experiments.
Chunk Duration--Aware SDN-Assisted DASH
Authors: Ozcelik Ihsan Mert , Ersoy Cem
Published: August 2019

Although Dynamic Adaptive Streaming over HTTP (DASH) is the pillar of multimedia content delivery mechanisms, its purely client-based adaptive video bitrate mechanisms have quality-of-experience fairness and stability problems in the existence of multiple DASH clients and highly fluctuating background traffic on the same shared bottleneck link. Varying chunk duration among different titles of multiple video providers exacerbates this problem. With the help of the global network view provided by the software-defined networking paradigm, we propose a centralized joint optimization module-assisted adaptive video bitrate mechanism that takes diversity of chunk sizes among different content into account. Our system collects possible video bitrate levels and chunk duration from DASH clients and simply calculates the optimal video bitrates per client based on the available capacity and chunk duration of each client’s selected content while not invading users’ privacy. By continuously following the background traffic flows, it asynchronously updates the target video bitrate levels to avoid both buffer stall events and network underutilization issues rather than bandwidth slicing, which brings about scalability problems in practice. It also guarantees fair startup delays for video sessions with various chunk duration. Our experiments clearly show that our proposed approach considering diversity of chunk duration and that background traffic fluctuations can significantly provide a better and fair quality of experience in terms of structural similarity--based video quality and startup delay compared to both purely client-based and state-of-the-art software-defined networking--based adaptive bitrate mechanisms.
Scheduling for Optimal File-Transfer Delay using Chunked Random Linear Network Coding Broadcast
Authors: Skevakis Emmanouil , Lambadaris Ioannis , Halabian Hassan
Published: August 2019

We study the broadcast transmission of a single file to an arbitrary number of receivers using Random Linear Network Coding (RLNC) in a network with unreliable channels. Due to the increased computational complexity of the decoding process (especially for large files), we apply
chunked
RLNC (i.e., RLNC is applied within non-overlapping subsets of the file).

In our work, we show the
optimality
of the
Least Received (LR)
batch scheduling policy with regards to the expected file transfer completion time. The
LR
policy strives to keep the receiver queues
balanced
. This is done by transmitting packets (corresponding to
encoded
batches) that are needed by the receivers with the shortest queues of successfully received packets. Furthermore, we provide formulas for the expected time for the file transmission to all receivers using the LR batch scheduling policy and the minimum achievable coding window size in the case of a pre-defined delay constraint. Moreover, we evaluate through simulations a modification of the LR policy in a more realistic system setting with reduced feedback from the receivers. Finally, we provide an initial analysis and further modifications to the
LR
policy for time-correlated channels and asymmetric channels.
Generalization of LRU Cache Replacement Policy with Applications to Video Streaming
Authors: Friedlander Eric , Aggarwal Vaneet
Published: August 2019

Caching plays a crucial role in networking systems to reduce the load on the network and is commonly employed by content delivery networks (CDNs) to improve performance. One of the commonly used mechanisms, Least Recently Used (LRU), works well for identical file sizes. However, for asymmetric file sizes, the performance deteriorates. This article proposes an adaptation to the LRU strategy, called gLRU, where the file is sub-divided into equal-sized chunks. In this strategy, a chunk of the newly requested file is added in the cache, and a chunk of the least-recently-used file is removed from the cache. Even though approximate analysis for the hit rate has been studied for LRU, the analysis does not extend to gLRU, since the metric of interest is no longer the hit rate as the cache has partial files. This article provides a novel approximation analysis for this policy where the cache may have partial file contents. The approximation approach is validated by simulations. Further, gLRU outperforms the LRU strategy for a Zipf file popularity distribution and censored Pareto file size distribution for the file download times. Video streaming applications can further use the partial cache contents to help the stall duration significantly, and the numerical results indicate significant improvements (32%) in stall duration using the gLRU strategy as compared to the LRU strategy. Furthermore, the gLRU replacement policy compares favorably to two other cache replacement policies when simulated on MSR Cambridge Traces obtained from the SNIA IOTTA repository.
Crossover Interference: Shedding Light on the Evolution of Recombination
Authors: Otto Sarah P. , Payseur Bret A.
Published: August 2019

Through recombination, genes are freed to evolve more independently of one another, unleashing genetic variance hidden in the linkage disequilibrium that accumulates through selection combined with drift. Yet crossover numbers are evolutionarily constrained, with at least one and not many more than one crossover per bivalent in most taxa. Crossover interference, whereby a crossover reduces the probability of a neighboring crossover, contributes to this homogeneity. The mechanisms by which interference is achieved and crossovers are regulated are a major current subject of inquiry, facilitated by novel methods to visualize crossovers and to pinpoint recombination events. Here, we review patterns of crossover interference and the models built to describe this process. We then discuss the selective forces that have likely shaped interference and the regulation of crossover numbers.
A 6-Gene Risk Signature Predicts Survival of Glioblastoma Multiforme
Authors: Zhao Jingwei , Wang Le , Hu Guozhang , Wei Bo
Published: August 2019

Background. This study aims to develop novel signatures for glioblastoma multiforme (GBM). Methods. GBM expression profiles from The Cancer Genome Atlas (TCGA) were downloaded and DEGs between tumor and normal samples were identified by differential expression analysis (DEA). A risk signature was developed by applying weighted gene coexpression network analysis (WGCNA) and Cox regression analysis. Patients were divided into high and low risk group, followed by evaluating the performance of the signature via Kaplan-Meier curve analysis. In addition, the prognostic significance of the signature was further validated using an independent validation dataset from Chinese Glioma Genome Atlas (CGGA). DEGs between high and low risk group were subjected to functional annotation. Results. A total of 748 DEGs were identified between primary tumor and normal samples. Following WGCNA and Cox regression analysis, 6 DEGs were identified and used to construct a risk signature. The signature showed high performance in both training and validation dataset. Subsequently, 397 DEGs were identified between high and low risk group. These DEGs were mainly enriched in terms related to calcium signaling, cAMP-mediated signaling, and synaptic transmission. Conclusions. The risk signature may contribute to GBM diagnosis in future clinical practice.
Carboxylated Multiwalled Carbon Nanotubes as Dispersive Solid-Phase Extraction Sorbent to Determine Eighteen Polychlorinated Biphenyls in Vegetable Samples by Gas Chromatography-Mass Spectrometry
Authors: Liu Tengfei , Yang Daifeng , Mao Jian , Zhang Xueming , Dong Minghui
Published: August 2019

A simple, rapid, and reliable method based on dispersive solid-phase extraction (d-SPE) and gas chromatography-mass spectrometry (GC-MS) was developed for quantitating polychlorinated biphenyls (PCBs) in vegetable samples. Parameters affecting both the extraction yields and cleanup efficiency, including the type and volume of extraction solvent, extraction time, type and volume of cleanup sorbent, and cleanup time, were optimized. Matrix effects were evaluated, and matrix-matched calibration was recommended. Under the optimized conditions, carboxylated multiwalled carbon nanotubes (MWCNTs-COOH), which exhibit excellent adsorption capabilities due to large surface area and unique structure, were employed as d-SPE sorbent to remove interfering substances, rather than the analytes, from vegetable samples. Satisfactory linear relationship was observed for all PCBs across a concentration range of 5–500 μg/kg with correlation coefficients no less than 0.9993. Four representative vegetables (cucumber, tomato, lettuce, and cabbage) were selected as matrices for method validation. Each matrix was spiked at concentrations of 5, 10, and 100 μg/kg to evaluate recoveries, which ranged from 84.5% to 116.5% with relative standard deviations (n=6) between 0.6% and 17.6%. The limits of detection and the limits of quantification ranged from 0.3 to 1.4 μg/kg and 0.8 to 4.5 μg/kg, respectively. Twelve real vegetable samples were analyzed using the proposed method. Three of the target PCBs were detected in one lettuce sample with the total concentration of 17.9 μg/kg.
Benchmarking COMSOL Multiphysics Single-Subchannel Thermal-Hydraulic Analysis of a TRIGA Reactor with RELAP5 Results and Experimental Data
Authors: Alkaabi Ahmed K. , King Jeffrey C.
Published: August 2019

COMSOL Multiphysics has been used to conduct thermal-hydraulic analysis in multiple nuclear applications. The aim of this study is to benchmark the prediction accuracy of COMSOL Multiphysics in performing thermal-hydraulic analysis of TRIGA (Training, Research, Isotopes, General Atomics) reactors such as the Geological Survey TRIGA Reactor (GSTR) by comparing its predictions with RELAP5 (a widely used code in nuclear thermal-hydraulic analysis) results and experimental data. The GSTR type is Mark I with a full thermal power of 1 MW, and it resides at the Denver Federal Center (DFC) in Colorado. The numerical investigation of the present work is carried out by developing single-subchannel thermal-hydraulic models of the GSTR utilizing RELAP5 and COMSOL codes. The models estimate the temperatures (fuel, outer clad, and coolant) and water flow patterns in the core as well as fuel element powers at which void starts to form within the coolant subchannels. Then, these models’ predictions are quantitatively evaluated and compared with the measured data.
How Does Leasing Affect Green Product Design?
Authors: Liu Jian , Wan Miyu , Jiang Weifan , Zhang Jinli
Published: August 2019

Leasing has been increasingly seen as a viable alternative to traditional business models. In this paper, we consider a manufacturer making decisions on green product design by accounting for the trade‐off between traditional and environmental qualities under three business models, including a pure selling, a pure leasing, and a hybrid model with both selling and leasing. Under leasing, there exists the pooling effect that allows a manufacturer to meet consumer needs with fewer products. Since the pooling effect decreases the marginal cost of production, leasing produces positive incentives to increase product quality. However, the cannibalization effect within the product line distorts the incentives so that the pooling effect only increases the traditional quality rather than the environmental quality. As a result, leasing may have a negative impact on the average environmental quality of products. The manufacturer should make business model choices depending on some factors, including the types of markets, the usage cost, and the pooling effect. In general, when the pooling effect is strong, the manufacturer prefers a leasing or hybrid model to selling but designs products with lower environmental quality than selling. When the pooling effect is weak, the optimal decision should be made depending on the types of markets and the usage cost: in the high‐end (low‐end) market, the manufacturer should adopt a leasing or hybrid model only when the usage cost is high (low); the adoption of leasing or hybrid model can improve the average environmental quality.
Quercetin Inhibits Inflammatory Response Induced by LPS from Porphyromonas gingivalis in Human Gingival Fibroblasts via Suppressing NF-κB Signaling Pathway
Authors: Xiong Gang , Ji Wansheng , Wang Fei , Zhang Fengxiang , Xue Peng , Cheng Min , Sun Yanshun , Wang Xia , Zhang Tianliang
Published: August 2019

Quercetin, a natural flavonol existing in many food resources, has been reported to be an effective antimicrobial and anti-inflammatory agent for restricting the inflammation in periodontitis. In this study, we aimed to investigate the anti-inflammatory effects of quercetin on Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide- (LPS-) stimulated human gingival fibroblasts (HGFs). HGFs were pretreated with quercetin prior to LPS stimulation. Cell viability was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. The levels of inflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), along with chemokine interleukin-8 (IL-8), were determined by enzyme-linked immunosorbent assay (ELISA). The mRNA levels of IL-1β, IL-6, IL-8, TNF-α, IκBα, p65 subunit of nuclear factor-kappa B (NF-κB), peroxisome proliferator-activated receptor-γ (PPAR-γ), liver X receptor α (LXRα), and Toll-like receptor 4 (TLR4) were measured by real-time quantitative PCR (RT-qPCR). The protein levels of IκBα, p-IκBα, p65, p-p65, PPAR-γ, LXRα, and TLR4 were characterized by Western blotting. Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1β, IL-6, IL-8, and TNF-α in a dose-dependent manner. It also suppressed LPS-induced NF-κB activation mediated by TLR4. Moreover, the anti-inflammatory effects of quercetin were reversed by the PPAR-γ antagonist of GW9662. In conclusion, these results suggested that quercetin attenuated the production of IL-1β, IL-6, IL-8, and TNF-α in P. gingivalis LPS-treated HGFs by activating PPAR-γ which subsequently suppressed the activation of NF-κB.
Study of the Stability Control of the Rock Surrounding Double‐Key Strata Recovery Roadways in Shallow Seams
Authors: Zhu Cheng , Yuan Yong , Chen Zhongshun , Liu Zhiheng , Yuan Chaofeng
Published: August 2019

The stability control of the rock surrounding recovery roadways guarantees the safety of the extraction of equipment. Roof falling and support crushing are prone to occur in double‐key strata (DKS) faces in shallow seams during the extraction of equipment. Therefore, this paper focuses on the stability control of the rock surrounding DKS recovery roadways by combining field observations, theoretical analysis, and numerical simulations. First, pressure relief technology, which can effectively release the accumulated rock pressure in the roof, is introduced according to the periodic weighting characteristics of DKS roofs. A reasonable application scope and the applicable conditions for pressure relief technology are given. Considering the influence of the eroded area on the roof structure, two roof mechanics models of DKS are established. The calculation results show that the yield load of the support in the eroded area is low. A scheme for strengthening the support with individual hydraulic props is proposed, and then, the support design of the recovery roadway is improved based on the time effects of fracture development. The width of the recovery roadway and supporting parameters is redesigned according to engineering experience. Finally, constitutive models of the support and compacted rock mass in the gob are developed with FLAC3D software to simulate the failure characteristics of the surrounding rock during pressure relief and equipment extraction. The surrounding rock control effects of two support designs and three extraction schemes are comprehensively evaluated. The results show that the surrounding rock control effect of Scheme 1, which combines improved support design and the bidirectional extraction of equipment, is the best. Engineering application results show that Scheme 1 realizes the safe extraction of equipment. The research results can provide a reference and experience for use in the stability control of rock surrounding recovery roadways in shallow seams.
Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas
Authors: Ohka Fumiharu , Shinjo Keiko , Deguchi Shoichi , Matsui Yusuke , Okuno Yusuke , Katsushima Keisuke , Suzuki Miho , Kato Akira , Ogiso Noboru , Yamamichi Akane , Aoki Kosuke , Suzuki Hiromichi , Sato Shinya , Arul Rayan Nirmala , Prabhakar Shyam , Göke Jonathan , Shimamura Teppei , Maruyama Reo , Takahashi Satoru , Suzumura Akio , Kimura Hiroshi , Wakabayashi Toshihiko , Zong Hui , Natsume Atsushi , Kondo Yutaka
Published: August 2019

Gliomas are classified by combining histopathologic and molecular features, including isocitrate dehydrogenase (IDH) status. Although IDH-wild-type diffuse astrocytic glioma (DAG) shows a more aggressive phenotype than IDH-mutant type, lack of knowledge regarding relevant molecular drivers for this type of tumor has hindered the development of therapeutic agents. Here, we examined human IDH-wild-type DAGs and a glioma mouse model with a mosaic analysis with double markers (MADM) system, which concurrently lacks p53 and NF1 and spontaneously develops tumors highly comparable with human IDH-wild-type DAG without characteristic molecular features of glioblastoma (DAG-nonMF). During tumor formation, enhancer of zeste homolog (EZH2) and the other polycomb repressive complex 2 (PRC2) components were upregulated even at an early stage of tumorigenesis, together with an increased number of genes with H3K27me3 or H3K27me3 and H3K4me3 bivalent modifications. Among the epigenetically dysregulated genes, frizzled-8 (Fzd8), which is known to be a cancer- and stem cell reprogramming–related gene, was gradually silenced during tumorigenesis. Genetic and pharmacologic inhibition of EZH2 in MADM mice showed reactivation of aberrant H3K27me3 target genes, including Fzd8, together with significant reduction of tumor size. Our study clarifies a pathogenic molecular pathway of IDH-wild-type DAG-nonMF that depends on EZH2 activity and provides a strong rationale for targeting EZH2 as a promising therapeutic approach for this type of glioma.

Significance:

EZH2 is involved in the generation of IDH-wild-type diffuse astrocytic gliomas and is a potential therapeutic target for this type of glioma.
Do cinema à literatura: "India Song" de Marguerite Duras
Authors: Kunkler Odara
Published: August 2019

O presente trabalho compara aspectos linguísticos e visuais do texto dramático India Song, da escritora francesa Marguerite Duras, com os do filme homônimo. Traz também conteúdos biográficos, almejando aprofundar-se no entendimento de suas escolhas e propostas estéticas. O argumento do artigo parte da vida da autora para a sua obra, e desta para o personagem que se repete, Anne-Marie Stretter. Podemos assim observar textos reescritos, em diversos suportes e diferentes épocas da vida da autora. São temas, personagens, lugares que sempre retornam ao imaginário de Duras, como fantasmas que assombram sua escrita.
Myrcia psammophila (Myrtaceae), a new species from the Amazonian white-sand vegetation

Authors: GAEM PAULO HENRIQUE , FARROÑAY FRANCISCO , MAZINE FIORELLA FERNANDA , VICENTINI ALBERTO
Published: August 2019

The new species Myrcia psammophila is here described, illustrated and compared with M. grandis and M. umbraticola, two morphologically similar taxa. It may be distinguished from these two latter species based on possession of leaves with corky petiole and raised midvein adaxially, and distinctly pedicellate flowers with squared staminal ring and sepals united at the base. This species is endemic to a region of lower Rio Negro and inhabits areas of white-sand vegetation.
Addendum to MANFRED R. ULITZKA (2019) Five new species of Rohrthrips (Thysanoptera: Rohrthripidae) from Burmese amber, and the evolution of Tubulifera wings. Zootaxa, 4585: 027–040.
Authors: ULITZKA MANFRED R.
Published: August 2019

Concerning the description of Rohrthrips patrickmuelleri Ulitzka (2019), it has been brought to my attention that the depositary and serial number of the holotype was not given. This information is given below in order to comply with ICZN, Article 16.4.2 (1999).
Professional identity and emerging occupational therapy practice: An autoethnography
Authors: Zubriski S. , Norman M. , Shimmell L. , Gewurtz R. , Letts L.
Published: August 2019

Background.

Research about occupational therapy practice in the community with people who have been imprisoned remains limited and may be considered an emerging area of practice.

Purpose.

This paper provides a critical, first-person account about emerging occupational therapy practice with men transitioning to the community post-imprisonment. The practice context is described and reflected on from the lens of a new graduate.

Methods.

Autoethnography draws meaning from reciprocal interactions between an individual and a culture. Data was collected by the primary author through reflective journal entries and process notes pertaining to a Photovoice project. Iterative application of established evaluative criteria served as a framework in an analytical writing process.

Findings.

Autethnography promoted self-reflection and professional development while Photovoice provided an evidence-based framework in an emerging setting.

Implications.

Current occupational therapy theories and models have limited applicability to inform practice with marginalized populations potentially benefitting from participatory research (e.g., Photovoice) and autoethnography.