bluuebunny/crossref_metadata_2025 huggingface dataset:
Steering benzyl alcohol electrooxidation coupled with hydrogen evolution via hetero‐interface construction
Authors: Du Xin , Xie Wenfu , Wang Yanfei , Li Hao , Li Jinze , Li Yang , Song Yuke , Li Zhenhua , Lee Jin Yong , Shao Mingfei
Published: May 2024

It is still a challenge to develop electrocatalyst for the efficient adsorption and conversion of organic molecule in aqueous media. Herein, a hetero‐interface structure based on CuO@Ni(OH)2 is rationally designed to enhance the performance of benzyl alcohol oxidation to benzoic acid. A high Faradaic efficiency of 99% and the yield of 3.09 mmol cm−2 h−1 are achieved at 1.70 V versus reversible hydrogen electrode, outperforming the previously reported electrocatalysts. Furthermore, a membrane‐free flow electrolyzer was assembled based on CuO@Ni(OH)2 hetero‐interface, exhibiting a much high yielding of benzoic acid (6.73 mmol cm−2 h−1) and hydrogen (0.35 L cm−2 h−1) with excellent stability. Both experimental data and density functional theory calculations verify that the electron is tend to accumulate at the hetero‐interface, thus accelerating the adsorption of reactant and intermediate and reducing the energy barrier of the conversion of benzyl alcohol to benzoic acid.
Clinical utility of comprehensive gene panel testing for common and rare causes of skeletal dysplasia and other skeletal disorders: Results from the largest cohort to date
Authors: MacCarrick Gretchen , Aradhya Swaroop , Bailey Mitch , Chu Dorna , Hunt Abigail , Izzo Emanuela , Krakow Deborah , Mackenzie William , Poll Sarah , Raggio Cathleen , Shediac Renée , White Klane K. , McLaughlin Heather M. , Seratti Guillermo
Published: May 2024

Molecular genetics enables more precise diagnoses of skeletal dysplasia and other skeletal disorders (SDs). We investigated the clinical utility of multigene panel testing for 5011 unrelated individuals with SD in the United States (December 2019–April 2022). Median (range) age was 8 (0–90) years, 70.5% had short stature and/or disproportionate growth, 27.4% had a positive molecular diagnosis (MDx), and 30 individuals received two MDx. Genes most commonly contributing to MDx were FGFR3 (16.9%), ALPL (13.0%), and COL1A1 (10.3%). Most of the 112 genes associated with ≥1 MDx were primarily involved in signal transduction (n = 35), metabolism (n = 23), or extracellular matrix organization (n = 17). There were implications associated with specific care/treatment options for 84.4% (1158/1372) of MDx‐positive individuals; >50% were linked to conditions with targeted therapy approved or in clinical development, including osteogenesis imperfecta, achondroplasia, hypophosphatasia, and mucopolysaccharidosis. Forty individuals with initially inconclusive results became MDx‐positive following family testing. Follow‐up mucopolysaccharidosis enzyme activity testing was positive in 14 individuals (10 of these were not MDx‐positive). Our findings showed that inclusion of metabolic genes associated with SD increased the clinical utility of a gene panel and confirmed that integrated use of comprehensive gene panel testing with orthogonal testing reduced the burden of inconclusive results.
Ultrastrong Graphene Sheets Assembled with Nanoconfined Water
Authors: Tang Zhiyong
Published: May 2024

Highly ordered assembly of two‐dimensional (2D) nanoplatelets plays a key role in enhancing the mechanical properties of layered nanocomposites. Layer‐by‐layer (LbL) assembly, vacuum‐assisted filtration, and blade coating have been used to fabricate layered nanocomposites. However, the intrinsic wrinkles of 2D nanoplatelets and defects derived from assembling approaches make it difficult to align 2D nanoplatelets. Recently, the team of Prof. Qunfeng Cheng at Beihang University and their collaborator, Prof. Ray H. Baughman at the University of Texas at Dallas developed a novel approach for aligning graphene and Ti3C2Tx MXene nanoplatelets by nanoconfined assembly through continuous vacuum‐assisted filtration. The resultant MXene‐bridged sheet has ultrastrong mechanical properties and low porosity, providing a new concept for assembling 2D nanoplatelets into aligned and compact high‐performance layered nanocomposites.
Effect of demineralized water on the silanization reaction and the performance properties of green tire tread compound
Authors: Neethirajan Jeevanandham , Natarajan Tamil Selvan , Mohanty Tapas Rajan , Ramakrishnan S. , Singha Nikhil K. , Naskar Kinsuk
Published: May 2024

Tire industries seek advancements in technologies ranging from novel constructions to new material systems for fuel efficiency. The chemical formulation of tread compounds and their processing conditions can significantly affect tire performance for key attributes, including rolling resistance, wet traction, and wear resistance. Adding demineralized water (DMW) molecules might enhance the silanization reaction between silane and silica filler surface via improved hydrolysis and condensation, resulting in a better silanization reaction. DMW was sprayed on a silica surface before mixing, incorporated with TESPD silane into S‐SBR/BR tire tread compound, and mixed in an internal mixer. The effects of an increase in the DMW content on compound processability, cure characteristics, filler dispersion, dynamic properties, and mechanical properties were investigated. Adding the water‐treated silica into the compound lowered the heat generation during mixing, lowered the dump temperature, lowered the tan δ (E″/E′) at 60°C, and increased the wet grip property by retaining the abrasion resistance compared with the control. The enhancement of filler dispersion was visualized via scanning electron microscope images. Reaction kinetics concerning the addition of water and the effect of the pH of water on the silanization reaction is also discussed using HPLC analysis.
Evaluation of various membranes at different fluxes to enable large‐volume single‐use perfusion bioreactors
Authors: Raza Hassan , Tang Tiffany , Gao Baizhen , Phuangthong Chelsea , Chen Chienhung Billy , Pinto Nuno D. S.
Published: May 2024

The growing demand for biological therapeutics has increased interest in large‐volume perfusion bioreactors, but the operation and scalability of perfusion membranes remain a challenge. This study evaluates perfusion cell culture performance and monoclonal antibody (mAb) productivity at various membrane fluxes (1.5–5 LMH), utilizing polyvinylidene difluoride (PVDF), polyethersulfone (PES), or polysulfone (PS) membranes in tangential flow filtration mode. At low flux, culture with PVDF membrane maintained higher cell culture growth, permeate titer (1.06–1.34 g/L) and sieving coefficients (≥83%) but showed lower permeate volumetric throughput and higher transmembrane pressure (TMP) (>1.50 psi) in the later part of the run compared to cultures with PES and PS membrane. However, as permeate flux increased, the total mass of product decreased by around 30% for cultures with PVDF membrane, while it remained consistent with PES and PS membrane, and at the highest flux studied, PES membrane generated 12% more product than PVDF membrane. This highlights that membrane selection for large‐volume perfusion bioreactors depends on the productivity and permeate flux required. Since operating large‐volume perfusion bioreactors at low flux would require several cell retention devices and a complex setup, PVDF membranes are suitable for low‐volume operations at low fluxes whereas PES membranes can be a desirable alternative for large‐volume higher demand products at higher fluxes.
Melatonin improves maternal sleep deprivation‐induced learning and memory impairment, inflammation, and synaptic dysfunction in murine male adult offspring
Authors: Zhang Yue‐Ming , Wei Ru‐Meng , Li Zong‐Yin , Li Xue‐Yan , Zhang Kai‐Xuan , Ge Yi‐Jun , Kong Xiao‐Yi , Liu Xue‐Chun , Chen Gui‐Hai
Published: May 2024

Introduction

Maternal sleep deprivation (MSD), which induces inflammation and synaptic dysfunction in the hippocampus, has been associated with learning and memory impairment in offspring. Melatonin (Mel) has been shown to have anti‐inflammatory, antioxidant, and neuroprotective function. However, the beneficial effect of Mel on MSD‐induced cognitive impairment and its mechanisms are unknown.

Methods

In the present study, adult offspring suffered from MSD were injected with Mel (20 mg/kg) once a day during postnatal days 61–88. The cognitive function was evaluated by the Morris water maze test. Levels of proinflammatory cytokines were examined by enzyme‐linked immunosorbent assay. The mRNA and protein levels of synaptic plasticity associated proteins were examined using reverse transcription‐polymerase chain reaction and western blotting.

Results

The results showed that MSD impaired learning and memory in the offspring mice. MSD increased the levels of interleukin (IL)‐1creIL‐6, and tumor necrosis factor‐α and decreased the expression levels of brain‐derived neurotrophic factor, tyrosine kinase receptor B, postsynaptic density protein‐95, and synaptophysin in the hippocampus. Furthermore, Mel attenuated cognitive impairment and restored markers of inflammation and synaptic plasticity to control levels.

Conclusions

These findings indicated that Mel could ameliorate learning and memory impairment induced by MSD, and these beneficial effects were related to improvement in inflammation and synaptic dysfunction.
Association between adding salt in food and dementia in European descent: A mendelian randomization study
Authors: Zhou Ren , Chen Fei , Zhang Lei , Sun Yu , Hu Rong , Yan Jia , Jiang Hong
Published: May 2024

Background

High salt intake has been proposed as a risk factor for dementia. However, causal relationship between salt intake and dementia remains uncertain.

Purpose

The aim of this study was to employ a mendelian randomization (MR) design to investigate the causal impact of salt intake on the risk of dementia.

Methods

Genome‐wide association study (GWAS) data of exposures and outcomes (any dementia, cognitive performance, different types of dementia, Alzheimer's disease [AD], and Parkinson's disease) were obtained from the IEU database. MR estimates were generated though inverse‐variance weighted model. MR‐Egger, weighted median, and MR‐Pleiotropy Residual Sum and Outlier (MR‐PRESSO) method also used in our study. Sensitivity analyses included Cochran's Q test, MR‐Egger intercept, MR‐PRESSO global test and outlier test, leave‐one‐out analysis, and funnel plot assessment.

Results

Our MR analysis provided evidence of a causal association between high salt added to food and dementia (odds ratio [OR] = 1.73, 95% confidence interval [CI]: 1.21–2.49, and p = .003), dementia in AD (OR = 2.10, 95% CI: 1.15–3.83, and p = .015), and undefined dementia (OR = 2.61, 95% CI: 1.26–5.39, and p = .009). Higher salt added was also associated with increased risk of AD (OR = 1.80, 95% CI: 1.12–2.87, and p = .014) and lower cognitive performance (β = −.133, 95% CI: −.229 to −.038, and p = .006).

Conclusion

This study provides evidence suggesting that high salt intake is causally associated with an increased risk of developing dementia, including AD and undefined dementia, highlighting the potential importance of reducing salt consumption as a preventive measure.
Antibody‐positive autoimmune encephalitis and paraneoplastic neurological syndrome: A Swedish case series
Authors: Kosek Sonja , Burman Joachim , Punga Anna Rostedt
Published: May 2024

Objective

This study aimed to explore the clinical characteristics and temporal disease course of patients with autoimmune encephalitis (AE) and paraneoplastic neurological syndrome (PNS) in Sweden.

Methods

Thirty‐seven antibody‐positive AE and PNS cases were identified in the Healthcare region Mid Sweden between 2015 and 2019. Clinical data were collected through a retrospective review of electronic health records. Patients were divided into three subgroups based on antibody type: neuronal surface antibodies (NSAbs), onconeural antibodies, and anti‐GAD65 antibodies.

Results

Nineteen patients had NSAbs, 11 onconeural antibodies, and seven anti‐GAD65 antibodies. Anti‐LGI1 and anti‐NMDAR were the most frequently detected NSAbs, with anti‐NMDAR cases having an older‐than‐expected age distribution (median age 40, range 17–72). Only 11 of 32 (30%) of patients had findings suggesting encephalitis on initial MRI, but 28 of 31 (90%) had pathological findings on initial cerebrospinal fluid analysis. All patients but one had abnormal EEG findings. Median time to immunotherapy was comparable among the three subgroups, whereas patients with anti‐LGI1, anti‐CASPR2, and anti‐IgLON5 had an eightfold longer time to immunotherapy than anti‐NMDAR and anti‐GABA‐B (p = .0016). There was a seasonal variation in onset for patients with non‐tumor‐related NSAbs and anti‐GAD65 antibodies, with most patients (72%) falling ill in spring or summer.

Conclusion

Swedish patients with AE and PNS had similar clinical characteristics as previously described cohorts from other geographical regions except for anti‐NMDAR encephalitis, with older onset than expected. The onset of non‐tumor‐related AE occurred predominantly in the warm seasons, and AE with a more insidious onset was associated with delayed treatment initiation.
Antibody drug conjugates in the clinic
Authors: Udofa Edidiong , Sankholkar Disha , Mitragotri Samir , Zhao Zongmin
Published: May 2024

Antibody‐drug conjugates (ADCs), chemotherapeutic agents conjugated to an antibody to enhance their targeted delivery to tumors, represent a significant advancement in cancer therapy. ADCs combine the precise targeting capabilities of antibodies and the potent cell‐killing effects of chemotherapy, allowing for enhanced cytotoxicity to tumors while minimizing damage to healthy tissues. Here, we provide an overview of the current clinical landscape of ADCs, highlighting 11 U.S. Food and Drug Administration (FDA)‐approved products and discussing over 500 active clinical trials investigating newer ADCs. We also discuss some key challenges associated with the clinical translation of ADCs and highlight emerging strategies to overcome these hurdles. Our discussions will provide useful guidelines for the future development of safer and more effective ADCs for a broader range of indications.
Dereplication Tools for Rhizophora mangle Extracts from Different Mangrove Areas and their Potential Against Staphylococcus aureus
Authors: da Silva Pontes Amanda Letícia , Monteiro Leal Carla , Pereira Lucas Manuela , Caamaño Muiño da Silva Gabriela , Braga Alves Peixoto João Vitor , Barbosa Succar Juliana , Ribeiro Flores Vinicius , Neves Direito Ida Carolina , Ribeiro da Silva Antonio Jorge , de Oliveira Chaves Filipe , Eccard Fingolo Catharina
Published: May 2024

Rhizophora extracts have several potential biological activities, and their metabolites can be used in the pharmaceutical industry. Extracts of Rhizophora species obtained from mangroves have shown prospective activity against Staphylococcus aureus. This study aimed to investigate the chemical profile of Rhizophora mangle leaves from fringe, basin, and transition mangrove zones and their bactericidal/bacteriostatic potential against S. aureus. R. mangle leaves were collected monthly in 2018 from litterfall in three different zones of the mangrove of Guaratiba State Reserve: fringe, basin, and transition. Extracts were prepared from the material collected in October and December for LC‐HRMS/MS analysis, and dereplication was performed using a molecular library search and the classical molecular networking GNPS platform. The minimum inhibitory concentrations (MICs) of the aqueous extract of R. mangle against S. aureus were determined. No S. aureus growth was observed compared to the control for extracts collected from September to December. Different compounds were annotated in each region, yet a marked presence of phenolic compounds was noted, among them glycosylated flavonoid derivatives of quercetin and kaempferol. The results suggest bactericidal/bacteriostatic activity for extracts of R. mangle leaves collected in 2018 from three mangrove forest zones.
Polymeric Reactors for Catalytic Reactions beyond Earth
Authors: Friedland Jens , Güttel Robert
Published: May 2024

Current space missions to Luna and Mars are considering to use the resources, which can be found on‐site at the destination. This strategy named in‐situ resource utilization (ISRU) saves valuable pay‐load capacities during the rocket launch from the earth surface. Specifically, in mars missions it is intended to produce the necessary rocket fuel CH4 for the back‐transit to earth via water electrolysis and subsequent CO2 methanation. The present study elaborates this concept and examines the question if polymeric reactors are feasible for heterogeneously catalyzed reactions in applications beyond earth. The study aims at providing a theoretical backbone for a proof‐of‐concept. The evaluation is conducted theoretically by design considerations and adds experimental results to show the general feasibility of polymeric reactors for applicable reaction conditions.
Advancing mid‐rectal cancer surgery: Unveiling the potential of natural orifice specimen extraction surgery in comparison to conventional laparoscopic‐assisted resection
Authors: Muhammad Shan , Jiang Zheng , Fan Tao , Tang QingChao , Hai Yang , Ehsan Sundas Bint E. , Bilal Maimoona , Zubayraeva Albina A. , Gao YiBo , He Jie
Published: May 2024

Background

Mid‐rectal cancer treatment traditionally involves conventional laparoscopic‐assisted resection (CLAR). This study aimed to assess the clinical and therapeutic advantages of Natural Orifice Specimen Extraction Surgery (NOSES) over CLAR.

Aims

To compare the clinical outcomes, intraoperative metrics, postoperative recovery, complications, and long‐term prognosis between NOSES and CLAR groups.

Materials & Methods

A total of 136 patients were analyzed, with 92 undergoing CLAR and 44 undergoing NOSES. Clinical outcomes were evaluated, and propensity score matching (PSM) was employed to control potential biases.

Results

The NOSES group exhibited significant improvements in postoperative recovery, including lower pain scores on days 1, 3, and 5 (p < .001), reduced need for additional analgesics (p = .02), shorter hospital stays (10.8 ± 2.3 vs. 14.2 ± 5.3 days; p < .001), and decreased intraoperative blood loss (48.1 ± 52.7 mL vs. 71.0 ± 55.0 mL; p = .03). Patients undergoing NOSES also reported enhanced satisfaction with postoperative abdominal appearance and better quality of life. Additionally, the NOSES approach resulted in fewer postoperative complications.

Conclusion

While long‐term outcomes (overall survival, disease‐free survival, and local recurrence rates) were comparable between the two methods, NOSES demonstrated superior postoperative outcomes compared to CLAR in mid‐rectal cancer treatment, while maintaining similar long‐term oncological safety. These findings suggest that NOSES could serve as an effective alternative to CLAR without compromising long‐term results.
EPO‐R: An efficient garbage collection scheme for long‐term transactions
Authors: Onishi Rina , Hoshino Takashi , Kawashima Hideyuki
Published: May 2024

This article proposes EPO‐R, which is an efficient garbage collection scheme designed for multi‐version concurrency control (MVCC) protocols. MVCC generates a version for each update operation, and it can exhaust physical memory for dynamically changing environments such as IoT payments. Eager pruning of obsolete versions (EPO) is a novel garbage collection technique for long‐term transactions. We found room for improvement in EPO, which triggers reclamation invocation. EPO is triggered for each write operation, and it wastes CPU resources. The proposed method EPO‐R is triggered on a read operation to address this issue. The result of experiments with 64 CPU cores and workloads with the combination of short‐term and long‐term transactions demonstrated that EPO‐R exhibited 6.3 times higher throughput than that of EPO. The reason for this can be explained by analyzing the number of unreclaimable versions.
Achieving Visible Light Triggered Overall Water Splitting over Plasmonic Au/SrTiO3:Al Photocatalyst
Authors: Zeng Bin , Zhou Qin , Ta Na , Wang Shengyang , Li Can , Li Rengui
Published: May 2024

The surface plasmon resonance (SPR) effect has garnered extensive attention in semiconductor photocatalysis for solar energy conversion, thanks to its remarkable optical properties. However, the majority SPR‐induced photocatalytic systems have been limited to achieving hydrogen evolution or oxygen evolution half reactions, and attaining overall water splitting on a SPR‐induced photocatalyst under visible light remains a formidable challenging. In this study, we employed a plasmonic photocatalyst Au/SrTiO3, and further enhanced its performance by doping aluminum (Al) into the SrTiO3 lattice (denoted as Au/SrTiO3:Al). By constructing reduction cocatalyst (RhCrOx) and oxidation cocatalyst (CoOOH), the Au/SrTiO3:Al photocatalyst successfully realizes photocatalytic overall water splitting with a stoichiometric ratio of H2 and O2 under visible light (λ≥440 nm). We revealed that the introduction of Al species effectively modified the electronic structure of SrTiO3, thereby enhancing the hydrogen evolution reaction in Au/SrTiO3:Al. Simultaneously, the RhCrOx and CoOOH cocatalysts synergistically capitalized on the short‐lived hot electrons and holes generated by the plasmonic Au/SrTiO3:Al photocatalyst, enabling to realize photocatalytic overall water splitting. This work offers a promising avenue for the rational design of plasmon‐induced overall water splitting photocatalysts through the integration of suitable cocatalysts and surface/interface engineering strategies.
Cytopathology: From its humble beginnings to the birth of the cytopathology fellowship
Authors: Sung Simon , Chaari Rema
Published: May 2024

Cytopathology or cytology as a field has grown remarkably in the 20th and 21st centuries with recent advances shaping the way we train our future colleagues and how we currently practice. This article explores the history of cytopathology tracing back as early as the 18th century with focus on the birth of the cytopathology fellowship in the United States.
The First International eDNA Workshop in Hong Kong: A beginner's guide for the next‐generation eDNA researcher
Authors: Seymour Mathew , Guibert Isis , Jeunen Gert‐Jan , Hellström Micaela , Leray Matthieu , Elbrect Vasco , Lau Anthony , Cutracci Maxine , How Chun Ming , Ip Jack Chi Ho , Liu Zifang , Moffitt Jessica , Qian Cheng , Qin Xian , Tse Cham Man , Wang Yifu , Wang Zhi , Zeng Xiaoyi , Zhao Meihong
Published: May 2024

The field of environmental DNA (eDNA) has rapidly advanced in recent years, providing a non‐invasive and time‐saving method for assessing biodiversity. The First International Environmental DNA (eDNA) Workshop in Hong Kong was held from 16 to 27 October 2023 and provided early career professionals with hands‐on training and collaboration opportunities in eDNA research. With support from The Croucher Foundation Limited (Hong Kong), the workshop covered all stages of an eDNA‐based research project, including study design, field sampling, eDNA extraction, library preparation, bioinformatics, statistical data analysis, and ethics in scientific research. Participants gained insights into the principles and practical applications of eDNA technology, emphasizing the importance of careful experimental design and data interpretation. The workshop also highlighted the need for standardized protocols, comprehensive and local DNA reference databases, and careful selection of primer sets to overcome current issues and limitations. Workshop participants expressed enthusiasm for the potential of eDNA metabarcoding as a valuable tool for ecological monitoring, biodiversity assessment, and conservation decision‐making. The future of eDNA research looks promising overall, with continued advancements in technology, collaboration among researchers, and the integration of eDNA into large‐scale ecological monitoring. Future iterations of the Hong Kong International eDNA workshop will continue to provide hands‐on training and collaboration opportunities for early career professionals interested in eDNA research, focusing on addressing current limitations and challenges in the field.
Construction of C5‐Indole Unnatural Amino Acid Motifs via Diastereoselective Pd(II)‐Catalyzed β‐C(sp3)‐H Functionalization
Authors: Patel Pooja , Babu Srinivasarao Arulananda , Tomar Radha
Published: May 2024

We report the construction of C5‐indole unnatural amino acid derivatives via the diastereoselective Pd(II)‐catalyzed prochiral β‐C(sp3)‐H arylation of racemic (DL), and enantiopure L‐ and D‐carboxamides of amino acids with 5‐iodoindoles. Independently, indole‐based compounds and amino acid motifs are important small molecules in organic synthesis and drug discovery research. This report aimed to contribute to enriching the library of indole‐based unnatural amino acid derivatives. The synthesis of examples of C5‐indole motif‐installed amino acid derivatives comprising norvaline, phenylalanine, leucine, norleucine, 2‐aminooctanoic acid having anti‐stereochemistry was accomplished. The synthesis of the C5‐indole motif‐containing non‐α‐amino acid (aminoalkanoic acid) derivatives was also reported. The C−H arylation reactions of racemic and enantiopure carboxamides with 5‐iodoindoles afforded the corresponding indole unnatural amino acid derivatives with good diastereoselectivity (anti, dr>95 : 5 and enantiopurity (er up to 99 : 1). Removal of the directing group (8‐aminoquinoline), phthalimide group and preparation of indole amino acid esters and free amino group‐containing indole unnatural amino acid motifs were also shown. The utility of the methodology was shown by synthesizing indole motif‐containing pyrrolidone and peptide molecules. The stereochemistry of the major (anti) diastereomers was ascertained from the X‐ray structure of a representative compound.
Exploring characteristics of and transitions between mental states within the Multi‐Action Plan model in high‐level judo
Authors: Kellermann Bernadette , Collins Dave , MacPherson Alan , Bertollo Maurizio
Published: May 2024

The Multi‐Action Plan (MAP) model presents an idiosyncratic framework for human performance. MAP research has categorised four Performance Types (PTs; T1–T4) using self‐paced activities. Specifically, T1–4 present four distinct mental states experienced by athletes during performance, differing, among other aspects, in the level of effort and perceived control. However, transitions between PTs are yet to be empirically investigated. This study aimed to examine MAP in the hyperdynamic open‐skill combat context of judo. We explored how judoka experienced PTs and the transition processes between these mental states. Six British, high‐level judoka (n = 6; Mdnage = 19) were interviewed using a retrospective semi‐structured interview schedule. Interpretative phenomenological analysis indicated that judo presents a hyperdynamic difficult‐to‐predict performance context due to the opponent and fighting rhythm. Second, participants strongly related to T2 and T3 and less to T1 and T4. They also reported experiences ‘between’ T2 and T3. Lastly, participants reported common transition pathways (e.g., T2–T3), typical transition cues, and specific trainable strategies to optimise performance. Findings are discussed in relation to existing literature. Lastly, we present limitations, applied, and research considerations.
Improving the identification of bone‐specific physical activity using wrist‐worn accelerometry: A cross‐sectional study in 11–12‐year‐old Australian children
Authors: Brailey Gemma , Metcalf Brad , Price Lisa , Cumming Sean , Rowlands Alex , Olds Timothy , Simm Peter , Wake Melissa , Stiles Victoria
Published: May 2024

Physical activity (PA) during childhood and adolescence is important for the accrual of maximal peak bone mass. The precise dose that benefits bone remains unclear as methods commonly used to analyze PA data are unsuitable for measuring bone‐relevant PA. Using improved accelerometry methods, this study identified the amount and intensity of PA most strongly associated with bone outcomes in 11–12‐year‐olds. Participants (n = 770; 382 boys) underwent tibial peripheral quantitative computed tomography to assess trabecular and cortical density, endosteal and periosteal circumference and polar stress‐strain index. Seven‐day wrist‐worn raw acceleration data averaged over 1‐s epochs was used to estimate time accumulated above incremental PA intensities (50 milli‐gravitational unit (mg) increments from 200 to 3000 mg). Associations between time spent above each 50 mg increment and bone outcomes were assessed using multiple linear regression, adjusted for age, sex, height, weight, maturity, socioeconomic position, muscle cross‐sectional area and PA below the intensity of interest. There was a gradual increase in mean R2 change across all bone‐related outcomes as the intensity increased in 50 mg increments from >200 to >700 mg. All outcomes became significant at >700 mg (R2 change = 0.6%–1.3% and p = 0.001–0.02). Any further increases in intensity led to a reduction in mean R2 change and associations became non‐significant for all outcomes >1500 mg. Using more appropriate accelerometry methods (1‐s epochs; no a priori application of traditional cut‐points) enabled us to identify that ∼10 min/day of PA >700 mg (equivalent to running ∼10 km/h) was positively associated with pQCT‐derived measures of bone density, geometry and strength in 11–12‐year‐olds.
Evaluation of the combined toxicity of heavy metals and chlorpyrifos: A comparison of electrochemical and MTT methods
Authors: Sun Mingze , Zhao Yaqian , Qi Shulan , Ye Cai , Zhang Jiahuan , Fei Chaoqun , Li Jinlian , Zhou Shi , Wu Dongmei
Published: May 2024

In the human living environment, heavy metals and chlorpyrifos can have harmful consequences due to their complex combination. In this study, binary, ternary, and quaternary combinations of three heavy metals and chlorpyrifos in different concentrations were evaluated for their combined toxic effects using an electrochemical method, and the MTT method was used to contrast the outcomes. The combined toxic effectiveness assessed by the electrochemical CI method revealed that, except for the binary combination of cadmium chloride and chlorpyrifos, which exhibited an antagonistic effect when mixed at an equal molar ratio, lead nitrate and chlorpyrifos showed an additive effect when combined, the quaternary combination exhibited a complex transition from synergistic to additive to antagonistic effects, the other mixtures showed consistent synergistic effects. When the ratio of heavy metals in the mixture was reduced, all of them displayed synergistic effects, except for the binary mixture of cadmium chloride and chlorpyrifos, which consistently maintained an antagonistic effect, and the ternary mixture of cadmium chloride, lead nitrate, and chlorpyrifos displayed additive effects. The complex toxicity mechanisms of the mixtures do not impact the response of cellular electrochemical signals coming from the intracellular purine bases on cytotoxicity. The electrochemical approach successfully captured the various combined toxic effects of the mixture, and the outcomes were consistent with the MTT method. This method is expected to emerge as a novel approach for detecting combined toxicity.
Demonstrating computer vision to small‐ and medium‐sized enterprises in manufacturing: Toward overcoming costs and implementation challenges
Authors: Werheid Jonas , Münker Sven , Klasen Nils , Hamann Tobias , Abdelrazeq Anas , Schmitt Robert H.
Published: May 2024

Computer vision (CV) systems are crucial in various fields, such as manufacturing. However, the general feedback from small and medium‐sized enterprises (SMEs) in manufacturing indicates that implementing CV systems are out of reach due to their high costs, the need for expertise, and the complexities of Machine Learning (ML). To demonstrate the feasibility and applicability for SMEs, we present a cost‐effective portable CV‐based demonstrator for SMEs in manufacturing. Incorporating low‐cost hardware components, the system integrates open‐source software and employs Transfer Learning to adapt pre‐existing ML models. We present two illustrative use cases with fault detection and inventory management based on plastic brick datasets including various colors and shapes to demonstrate the system's effectiveness. Bringing this into a showable demonstrator, all components are integrated into a portable suitcase as a plug and play demonstration. We showcase the portable demonstrator at German television and four different industrial fairs, leveraging these dynamic platforms for direct interaction with SMEs and stakeholders. Firsthand insights and feedback from SMEs regarding our demonstration and their challenges, as well as opportunities for CV in manufacturing were received and summarized in this research.
Improving the flame retardancy and smoke suppression of flexible PVC by incorporating zinc borate‐modified diantimony trioxide
Authors: Zhang Bin , Zeng Shaohua
Published: May 2024

The properties and structure of flexible PVC by incorporating zinc borate (ZB)‐modified diantimony trioxide (Sb2O3) were investigated. The results of flame retardancy and smoke suppression testing indicate that there was an obvious maximum Limited oxygen index (LOI) value of PVC/20 wt.% ZB–Sb2O3 composites reached 37.5% and passed the UL 94 V‐0 rating. An obvious synergistic effect between ZB and Sb2O3 was observed by LOI, SDR, and TG. Moreover, remarkable decreases in the smoke density were observed when ZB–Sb2O3 was incorporated into PVC. In addition, the tensile strength and elongation at break of PVC/ZB–Sb2O3 composites was higher than PVC/Sb2O3 composites, and this ameliorative effect was mainly arising from the ZB–Sb2O3 nanoparticles, which reduced the degree of fatal defects on PVC. The addition of ZB and Sb2O3 greatly increased the amount of residual char and apparently improved the mechanical properties of PVC composites. According to scanning electron microscopy photographs of residual char, after thermal decomposition, there were many fragments linked to the condensed phase and the compact char layer. Fourier transform infrared spectroscopy shows the residues char was composed of benzene ring, the flame retardants occurred and the condensed phase with significant interactions.
How far are we off? Analyzing the accuracy of surgical margin relocation in the head and neck
Authors: Miller Alexis , Wang Vickie , Jegede Victor , Necker Fabian , Curry Joseph , Baik Fred M. , Verma Avanti , Holsinger F. Christopher , Tuluc Madalina , Rahman Mobeen , Lewis James S. , Rosenthal Eben , Topf Michael C.
Published: May 2024

Background

Positive surgical margin rates remain high in head and neck cancer surgery. Relocation is challenging given the complex, three‐dimensional (3D) anatomy.

Methods

Prospective, multi‐institutional study to determine accuracy of head and neck surgeons and pathologists relocating margins on virtual 3D specimen models using written descriptions from pathology reports. Using 3D models of 10 head and neck surgical specimens, each participant relocated 20 mucosal margins (10 perpendicular, 10 shave).

Results

A total of 32 participants, 23 surgeons and 9 pathologists, marked 640 margins. Of the 320 marked perpendicular margins, 49.7% were greater than 1 centimeter from the true margin with a mean relocation error of 10.2 mm. Marked shave margins overlapped with the true margin a mean 54% of the time, with no overlap in 44 of 320 (13.8%) shave margins.

Conclusions

Surgical margin relocation is imprecise and challenging even for experienced surgeons and pathologists. New communication technologies are needed.
Complete rupture of the pregnant uterus: A 12‐year retrospective study
Authors: Zhang Li , Chen Liang , Hong Xunyu , Zheng Dan , Ying Hongjun , Hong Ling
Published: May 2024

Objective

To assess the frequency of uterine ruptures, clinical characteristics, and maternal and neonatal outcomes in a tertiary referral center.

Methods

Information on complete uterine rupture between July 2010 and June 2022 was investigated retrospectively at a tertiary center.

Results

There were 42 cases of complete uterine rupture in 144 474 deliveries, with an incidence rate of 0.029%. Twenty‐seven cases had a scarred uterus and 15 had an unscarred uterus; Rupture of the lower uterine segment was predominant in the scarred uterus, whereas rupture of the body of the uterus was predominant in the non‐scarred uterus (P ≤ 0.001). Newborns with Apgar score of 7 or less at 1 min in the non‐scarred uterus group was more than that in the scarred uterus group (P = 0.001). There were no significant differences in the history of gynecologic surgery, induction of labor, mode of delivery, clinical features, maternal outcomes, neonatal weight, preterm birth rate, 5‐min Apgar score, or neonatal mortality between the two groups (P > 0.05).

Conclusion

The clinical manifestations of uterine rupture are mainly abdominal pain, abnormal fetal heartbeat, or vaginal bleeding. Attention should also be paid to the history of previous uterine surgery. Strict prenatal management, early identification, and aggressive management can help improve maternal and child outcomes. Hysterectomy is not imperative.
MzDOCK: A free ready‐to‐use GUI‐based pipeline for molecular docking simulations
Authors: Kabier Muzammil , Gambacorta Nicola , Trisciuzzi Daniela , Kumar Sunil , Nicolotti Orazio , Mathew Bijo
Published: May 2024

Molecular docking is by far the most preferred approach in structure‐based drug design for its effectiveness to predict the scoring and posing of a given bioactive small molecule into the binding site of its pharmacological target. Herein, we present MzDOCK, a new GUI‐based pipeline for Windows operating system, designed with the intent of making molecular docking easier to use and higher reproducible even for inexperienced people. By harmonic integration of python and batch scripts, which employs various open source packages such as Smina (docking engine), OpenBabel (file conversion) and PLIP (analysis), MzDOCK includes many practical options such as: binding site configuration based on co‐crystallized ligands; generation of enantiomers from SMILES input; application of different force fields (MMFF94, MMFF94s, UFF, GAFF, Ghemical) for energy minimization; retention of selectable ions and cofactors; sidechain flexibility of selectable binding site residues; multiple input file format (SMILES, PDB, SDF, Mol2, Mol); generation of reports and of pictures for interactive visualization. Users can download for free MzDOCK at the following link: https://github.com/Muzatheking12/MzDOCK.
Exploration of a novel protease from Phytolacca dodecandra (Endod) berries for potential application in detergent formulation
Authors: Anbesaw Muhammed Seid , Worku Getahun
Published: May 2024

Conventional detergent formulations contain either petroleum‐derived or synthetic chemicals. Hence, the replacement of these chemicals with natural products such as enzymes is considered a green technology. Among these enzymes, protease is renowned in detergent formulations. Therefore, the objective of this study was to explore and characterize a new protease from Phytolacca dodecandra, because the plant is traditionally known for detergency purposes. Enzyme extraction was performed with Glycine/NaOH buffer, pH = 10.0. Gelatin hydrolysis and agar well diffusion tests were implemented as qualitative assays, whereas the enzyme assay technique was applied for the quantitative investigation of the new protease from plant extracts. The crude enzyme was partially characterized concerning temperature and pH tolerance, washing performance, detergent compatibility, and stability. The finding of this study revealed that Phytolacca dodecandra contains protease and is characterized by 1418.84 U/mL of enzyme activity, where 1 unit (U) of enzyme activity refers to the amount of enzyme required to liberate 1 μg of tyrosine/mL/min under the defined assay conditions. The enzyme showed maximum activity at pH 10.5 and 45°C. The enzyme was stable and maintained 99.52% activity at 40°C and 91.73% at pH 10.0 after 2 h pre‐incubation. The enzyme showed excellent wash performance and could potentially remove blood stains completely within 3 min. After 2 h of pre‐incubation the enzyme maintained 69.06% and 54.88% of its activity in the presence of Azzy and Sunlight, respectively. The enzyme maintained 71.99% of its residual activity after 60 days of storage. If further studies are conducted, all these properties of the newly investigated protease can make the enzyme applicable in detergent formulations.
Mild surfactant systems containing rhamnolipids for personal cleansers—Building the viscosity and studying the performance
Authors: Li Nan , Shen Hongwei , Wu Shijian , Potanin Andrei , Lee Jonghun
Published: May 2024

Biosurfactants represent a promising choice for the development of environmentally friendly and gentle personal care cleansers. Building viscosity is one of the major challenges to apply biosurfactants. In this study, sodium lauroyl sarcosinate (LS) and sodium lauroamphoacetate (LA) were used as bases to build wormlike micelles, and subsequently rhamnolipids were introduced to build mild surfactant systems. The LS‐LA mixture had the highest viscosity at the mass ratio of 1:5 and pH 6.0. After adding 1 wt% and less rhamnolipid, relatively high viscosity can be maintained. The viscosity of LS‐LA‐rhamnolipid can be increased by adding NaCl and more significantly by the addition of carrageenan due to its synergistic interactions with the surfactant mixture. In addition, the foaming properties of the systems are characterized with different amounts of rhamnolipid and carrageenan, which are correlated with the bulk viscosity and interfacial elasticity of the diluted solution used for the foaming test. Rhamnolipids have both high mildness and cleaning efficacy and adding rhamnolipids can significantly increase the mildness of the system. This study offers practical solutions for the incorporation of rhamnolipids or other biosurfactants in the formulation of personal care cleansers.
The Usefulness of Ultrasonography for Supporting the Differentiation, Diagnosis, and Treatment of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma
Authors: Crisan Diana , Schneider Lars Alexander , Scharffetter‐Kochanek Karin , Bernhard Lukas , Crisan Maria , Wortsman Ximena
Published: May 2024

Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare histomorphological variants of a disease spectrum. After ruling out other tumor entities by immunohistochemistry, PDS can be differentiated from AFX by infiltration into the subcutis, while AFX remains confined to the dermis. The therapeutic approach is more aggressive in PDS as it can potentially metastasize. We assessed the usefulness of preoperative sonography in differentiating between the two tumor entities by identifying a potential subcutaneous infiltration. In our patients (n = 13), preoperative sonography identified and differentiated AFX and PDS with 100% accuracy and even changed the initial histological suspicion of AFX to PDS in 3 cases (23%), which was confirmed after tumor resection. Preoperative sonography of these tumors could strengthen the clinical diagnosis, avoid a delay in therapy initiation and improve patient counseling. While for AFX, micrographic‐controlled surgery suffices, for PDS, resection with 2 cm safety margins and lymph node sonography to rule out lymphonodal involvement is necessary. Hence, ultrasonography can improve clinical practice by providing helpful information for dermatosurgeons, which cannot be obtained during clinical examination.
Single‐Panel Complex Holographic Display with Three‐Phase Covalent Macropixel
Authors: Kim Yunhee , Lee Jonghyun , Na Sehwan , Song Hoon , Kim Soobin , Yu Hyeonseung , Ahn Jungkwon , Choi Chilseong , Kim Hongsuk , Lee Hong‐Seok , Kim Hwi
Published: May 2024

A single‐panel complex holographic display with a three‐phase covalent macropixel featuring ultralow noise and high‐efficiency 3D image generation is proposed. The essential feature of the proposed three‐phase covalent macropixel is the point‐symmetric covalent concatenation of sub‐pixels and an adaptive computer‐generated hologram encoding algorithm. The proposed single‐panel holographic display exhibits three times signal efficiency enhancement, 1/38 reduction of DC noise, and 1/50 reduction of conjugate noise compared to conventional holographic displays in the generation of full‐color computer‐generated hologram images. This noise reduction leads to three times the optical efficiency enhancement of holographic displays.
Narrative transportation: A systematic literature review and future research agenda
Authors: Thomas Veronica L. , Grigsby Jamie L.
Published: May 2024

Consumers are inundated with opportunities to become engaged with marketing‐generated stories, from watching an influencer detail her adventures abroad or a commercial about a military service member who makes it home just in time for the holidays. When consumers become so engaged with a story that they begin to connect with the story characters and imagine what will happen next, they experience a process known as narrative transportation, which has significant positive outcomes for marketers. Given the value that narrative transportation provides to marketers, we conduct a systematic literature review to both synthesize and provide direction on the literature of narrative transportation. From our analysis of 95 peer‐reviewed articles, we identify relevant theoretical foundations and concepts (antecedents, outcomes, and moderators) employed in these articles. Using these results as our foundation, we detail how narrative transportation has evolved in terms of both the presentation of the story and the antecedents that affect narrative transportation. Further, we present a conceptual model that will represent the next iteration of the narrative transportation framework and suggest avenues for future research. In doing so, we enable researchers to continue the exploration of the narrative transportation construct.
A neural network copula function approach for solving joint basic probability assignment in structural reliability analysis
Authors: Yang Rui‐Shi , Sun Li‐Jun , Li Hai‐Bin , Yang Yong
Published: May 2024

Applying evidence theory to structural reliability analysis under epistemic uncertainty, it is necessary to consider the correlation of evidence variables. Among them, solving the joint basic probability assignment (BPA) of the evidence variables is a crucial link. In this study, a solution method of joint BPA based on neural network copula function is proposed. This method is to automatically construct copula function through neural network, which avoids the process of selecting the optimal copula function. Firstly, the neural network copula function is constructed based on the sample set of evidence variables. Then, the expression for solving the joint BPA using the neural network copula function is derived through vectors. Furthermore, the expression is used to map the marginal BPA of evidence variables to joint BPA, thus realizing the solution of joint BPA. Finally, the effectiveness of this method is verified by three examples. The results show that the neural network copula function describes the data distribution better than the optimal copula function selected by the traditional method. In addition, there is actually an error in solving the reliability intervals using the traditional optimal copula function method, whereas the results of this paper's neural network copula function method are more accurate and better for decision making.