bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptive distributed MPC based load frequency control with dynamic virtual inertia of offshore wind farms
Authors: Qi Xiao , Lei Lingyao , Yu Changhui , Ma Zekai , Qu Taotao , Du Ming , Gu Miaosong
Published: February 2024

The penetration of offshore wind farms (OWFs) in city‐close power systems is rapidly increasing. System inertia will be further reduced. Active frequency support of wind power is essential to solve the load frequency control (LFC) problem. Here, the dynamic virtual inertia control (VIC) method is employed to enhance frequency stability within the permitted operating states of OWFs. An adaptive distributed model predictive control (DMPC) method is proposed and applied to an interconnected power system. The dynamic VIC‐based LFC model is derived and used to construct the predictive model of DMPC. To expand the adaptation of the analytical linearized model of OWFs in different operating points, the adaptive law is further designed to dynamically adjust the parameters of DMPC. The simulation results demonstrate the effectiveness of the proposed control method. The frequency fluctuations can be well‐restrained under different disturbances.
Fluid–structure interaction simulation and optical fibre stress analysis of submarine cables in vortex‐induced vibration
Authors: Tan Haotian , Hao Yanpeng , Zhang Yining , Zhang Peng , Li Qishun , Yang Lin , Li Licheng
Published: February 2024

Under the current scouring, submarine cables are prone to be exposed, suspended, and even vortex‐induced vibration (VIV), threatening their mechanical and electrical properties. In this contribution, a finite element simulation model of 110‐kV single‐core optical fibre composite submarine cable is established. The natural frequency and resonant frequency of the model are obtained through wet mode analysis and harmonic response analysis. Then the VIV is simulated by the fluid–structure coupling method. Moreover, the stress extraction method of the torsional optical fibre position under the VIV is proposed. The results show that when the reduced speed is 2.57, the submarine cable appears beating vibration, which is composed of two vibrations with similar frequencies. When the reduced speed is 7.08, the vibration frequency is about 7.813 Hz, causing a rapid increase in vibration amplitude. The stress distribution of the torsional optical fibre presents a mirror image relationship at two moments separated by half a vibration cycle. Also, the frequency of stress change is the same as the frequency of VIV, which can judge whether the VIV occurs. The VIV range and position can be determined by the location where the stress changes the most.
Investigating delay of the media access control protocols for IoT‐RoF using quantum entanglement
Authors: Ahmad Shakir Salman , Al‐Raweshidy Hamed , Nilavalan Rajagopal
Published: February 2024

One of the significant challenges of the Radio over fibre (RoF) Medium Access Control (MAC) protocol is the propagation delay. This delay can lead to serious issues, such as higher propagation delay resulting in collisions and unnecessary retransmissions. Quantum entanglement is an excellent candidate to overcome the propagation delay of the RoF MAC protocol. A new quantum MAC protocol is proposed, named the Quantum Entanglement‐based MAC protocol (QE‐MAC), in which Quantum Teleportation is utilised to address the propagation delay. Four entanglement states are employed to represent the control packets of the classical MAC protocol, and data is transmitted over the classical channel. Instead of using control packets such as acknowledgement, request to send, and Clear to send, state transitions are employed. This approach avoids the delay and collision issues associated with control packets, resulting in a significant improvement in network performance. The delay, duty cycle (DC), and power consumption of the proposed QE‐MAC protocol are formulated and derived. The protocol is evaluated in terms of delay, DC, and power consumption, demonstrating superior performance compared to the classical RoF MAC protocol. In comparison to published works, our proposed approach has successfully reduced both delay and power consumption by 35%.
Super‐evolutionary mechanism and Nelder‐Mead simplex enhanced salp swarm algorithm for photovoltaic model parameter estimation
Authors: Wu Huangying , Chen Yi , Cai Zhennao , Heidari Ali Asghar , Chen Huiling , Zhang Yudong
Published: February 2024

In the pursuit of enhancing the efficiency of solar cells, accurate estimation of unspecified parameters in the solar photovoltaic (PV) cell model is imperative. An advanced salp swarm algorithm called the Super‐Evolutionary Nelder‐Mead Salp Swarm Algorithm (SENMSSA) is proposed to achieve this objective. The proposed SENMSSA addresses the limitations of SSA by incorporating a super‐evolutionary mechanism based on a Gaussian‐Cauchy mutation and a vertical and horizontal crossover mechanism. This mechanism enhances both the global optimization capabilities and the local search performance and convergence speed of the algorithm. It enables a secondary refinement of the global optimum, unlocking untapped potential in the solution space near the global optimum and elevating the algorithm's precision and exploitation capabilities to higher levels. The Nelder‐Mead simplex method is further introduced to enhance local search capabilities and convergence accuracy. The Nelder‐Mead simplex method is a versatile optimization algorithm that improves local search by iteratively adjusting a geometric shape (simplex) of points. It operates without needing derivatives, making it suitable for non‐smooth or complex objective functions. To assess the efficacy of SENMSSA, a comparative analysis is conducted against other available algorithms, namely SSA, IWOA, SCADE, LWOA, CBA, and RCBA, using the CEC2014 benchmark function set. Subsequently, the algorithm was employed to determine the unknown PV parameters under fixed conditions for three different diode models. Additionally, SENMSSA is utilized to estimate PV parameters for three commercially available PV models (ST40, SM55, KC200GT) under varying conditions. The experimental results indicate that the SENMSSA proposed in this study displays a remarkably competitive performance in all test cases compared to other algorithms. As such, we consider that the SENMSSA algorithm constitutes a reliable and efficient solution for the challenge of PV parameter estimation.
The Gaia-ESO Survey: Calibrating the lithium–age relation with open clusters and associations
Authors: Gutiérrez Albarrán M. L. , Montes D. , Tabernero H. M. , González Hernández J. I. , Marfil E. , Frasca A. , Lanzafame A. C. , Klutsch A. , Franciosini E. , Randich S. , Smiljanic R. , Korn A. J. , Gilmore G. , Alfaro E. J. , Bensby T. , Biazzo K. , Casey A. , Carraro G. , Damiani F. , Feltzing S. , François P. , Jiménez Esteban F. , Magrini L. , Morbidelli L. , Prisinzano L. , Prusti T. , Worley C. C. , Zaggia S. ,   GES builders
Published: February 2024

Context. The Li abundance observed in pre-main sequence and main sequence late-type stars is strongly age-dependent, but also shows a complex pattern depending on several parameters, such as rotation, chromospheric activity, and metallicity. The best way to calibrate these effects, and with the aim of studying Li as an age indicator for FGK stars, is to calibrate coeval groups of stars, such as open clusters (OCs) and associations.

Aims. We present a considerable target sample of 42 OCs and associations – with an age range from 1 Myr to 5 Gyr – observed within the Gaia-ESO survey (GES), and using the latest data provided by GES iDR6 and the most recent release of Gaia that was then available, EDR3. As part of this study, we update and improve the membership analysis for all 20 OCs presented in our previous article.

Methods. We perform detailed membership analyses for all target clusters to identify likely candidates, using all available parameters provided by GES, complemented with detailed bibliographical searches, and based on numerous criteria: from radial velocity distributions, to the astrometry (proper motions and parallaxes) and photometry provided by Gaia, to gravity indicators (log g and the γ index), [Fe/H] metallicity, and Li content in diagrams of (Li equivalent widths) EW(Li) versus Teff.

Results. We obtain updated lists of cluster members for the whole target sample, as well as a selection of Li-rich giant contaminants obtained as an additional result of the membership process. Each selection of cluster candidates was thoroughly contrasted with numerous existing membership studies using data from Gaia to ensure the most robust results.

Conclusions. These final cluster selections will be used in the third and last paper of this series, which reports the results of a comparative study characterising the observable Li dispersion in each cluster and analysing its dependence on several parameters, allowing us to calibrate a Li–age relation and obtain a series of empirical Li envelopes for key ages in our sample.
Liebe Leserinnen und Leser,
Authors: Bischoff Stephan C.
Published: February 2024

Das erste Heft der Aktuellen Ernährungsmedizin liegt vor! Mit
interessanten Beiträgen wie „Zöliakie bei Kindern:
Nährstoffdefiziten unter glutenfreier Diät entgegenwirken“
(Kommentierte Wissenschaft), „Der MEDPass-Verabreichungsmodus oraler
Nahrungssupplemente – vom Entscheid bis zur Nachbetreuung“
(Originalarbeit) und „Schwangerschaft und Stillzeit bei Morbus
Crohn“ (CME-Beitrag).
Neurosonology Survey in Europe and Beyond
Authors: Baracchini Claudio , Azevedo Elsa , Walter Uwe , Sargento-Freitas João , Malojcic Branko ,   for the Council of Nations of the European Society of Neurosonology
                        and Cerebral Hemodynamics (ESNCH)
Published: February 2024

Purpose To provide an overview on education, training, practice
requirements, and fields of application of neurosonology in Europe and
beyond.

Materials and Methods National representatives and experts in
neurosonology were surveyed regarding neurosonology requirements and practice in
their countries. Descriptive statistics were used to report the data.

Results Between February 1 and March 31, 2023, 42/46 (91.3%) national
representatives responded to our questionnaire and the completion rate was 100%.
Most countries (71.4%) offer a neurosonology training program during neurology
residency, but it is part of the undergraduate medical program only in 30.9%.
National certification is available in 47.6% of the countries surveyed and most
countries (76.2%) require certification to practice. In 50% of the countries,
candidates are assessed by a board examination, while in 26.2% they just need to
document their practice. There is no formal accreditation of neurosonology
centers in 78.6% of the countries surveyed. Only a few require certified
personnel and appropriate equipment. Adequate teaching and research activities
are only rarely necessary elements for laboratory accreditation.

Conclusion Our results indicate that there is a substantial need for
transnational harmonization of neurosonological standards to guarantee
uniformity and quality of performance. This survey will also provide guidance to
promote an international accrediting council and create a quality-controlled
laboratory network for implementing neurosonology in clinical trials.
Implications of Heat Stress-induced Metabolic Alterations for
Endurance Training
Authors: Bennett Samuel , Tiollier Eve , Owens Daniel J. , Brocherie Franck , Louis Julien B.
Published: February 2024

Inducing a heat-acclimated phenotype via repeated heat stress improves exercise
capacity and reduces athletes̓ risk of hyperthermia and heat illness. Given the
increased number of international sporting events hosted in countries with
warmer climates, heat acclimation strategies are increasingly popular among
endurance athletes to optimize performance in hot environments. At the tissue
level, completing endurance exercise under heat stress may augment endurance
training adaptation, including mitochondrial and cardiovascular remodeling due
to increased perturbations to cellular homeostasis as a consequence of metabolic
and cardiovascular load, and this may improve endurance training adaptation and
subsequent performance. This review provides an up-to-date overview of the
metabolic impact of heat stress during endurance exercise, including proposed
underlying mechanisms of altered substrate utilization. Against this metabolic
backdrop, the current literature highlighting the role of heat stress in
augmenting training adaptation and subsequent endurance performance will be
presented with practical implications and opportunities for future research.
GAS6/TAM Axis as Therapeutic Target in Liver Diseases
Authors: Tutusaus Anna , Morales Albert , García de Frutos Pablo , Marí Montserrat
Published: February 2024

TAM (TYRO3, AXL, and MERTK) protein tyrosine kinase membrane receptors and their vitamin K-dependent ligands GAS6 and protein S (PROS) are well-known players in tumor biology and autoimmune diseases. In contrast, TAM regulation of fibrogenesis and the inflammation mechanisms underlying metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and, ultimately, liver cancer has recently been revealed. GAS6 and PROS binding to phosphatidylserine exposed in outer membranes of apoptotic cells links TAMs, particularly MERTK, with hepatocellular damage. In addition, AXL and MERTK regulate the development of liver fibrosis and inflammation in chronic liver diseases. Acute hepatic injury is also mediated by the TAM system, as recent data regarding acetaminophen toxicity and acute-on-chronic liver failure have uncovered. Soluble TAM-related proteins, mainly released from activated macrophages and hepatic stellate cells after hepatic deterioration, are proposed as early serum markers for disease progression. In conclusion, the TAM system is becoming an interesting pharmacological target in liver pathology and a focus of future biomedical research in this field.
Clinical and Radiographic Outcomes of Anterior Lumbar Interbody Fusions Using a Titanium Cage with a Biomimetic Surface
Authors: Jowdy Patrick K. , Soliman Mohamed A.R. , Quiceno Esteban , Azmy Shady , Popoola Daniel O. , Aguirre Alexander O. , Khan Asham , Slosar Paul J. , Pollina John , Mullin Jeffrey P.
Published: February 2024

Background We analyzed clinical and radiographic outcomes in patients undergoing anterior lumbar interbody fusions (ALIFs) using a new biomimetic titanium fusion cage (Titan nanoLOCK interbody, Medtronic, Minneapolis, Minnesota, United States). This specialized cage employs precise nanotechnology to stimulate inherent biochemical and cellular osteogenic reactions to the implant, aiming to amplify the rate of fusion. To our knowledge, this is the only study to assess early clinical and radiographic results in ALIFs.

Methods We conducted a retrospective review of data for patients who underwent single or multilevel ALIF using this implant between October 2016 and April 2021. Indications for treatment were spondylolisthesis, postlaminectomy syndrome, or spinal deformity. Clinical and radiographic outcome data for these patients were collected and assessed.

Results A total of 84 patients were included. The mean clinical follow-up was 36.6 ± 14 months. At 6 months, solid fusion was seen in 97.6% of patients. At 12 months, solid fusion was seen in 98.8% of patients. Significant improvements were seen in patient-reported outcome measures (PROMs; visual analog scale and Oswestry Disability Index) at 6 and 12 months compared with the preoperative scores (p < 0.001). One patient required reoperation for broken pedicle screws 2 days after the ALIF. None of the patients required readmission within 90 days of surgery. No patients experienced an infection.

Conclusions ALIF using a new titanium interbody fusion implant with a biomimetic surface technology demonstrated high fusion rates (97.6%) as early as 6 months. There was significant improvement in PROMs at 6 and 12 months.
Anesthetic Management of Transoral Odontoidectomy in a Child with Multiple Drugs Intolerance Syndrome
Authors: Ajayan Neeraja , Hrishi Ajay P. , Divakar Ganesh
Published: February 2024

Patients with an adverse reaction to more than three groups of drugs have multiple drug intolerance syndrome (MDIS). Regional anesthesia can be an attractive alternative when patients presenting for surgery are diagnosed with MDIS for opioids and nonsteroidal anti-inflammatory drugs (NSAIDs). Moreover, supplementary regional anesthetic techniques reduce exposure to multiple anesthetic medications, reducing the incidence of allergic reactions. We report the case of a pediatric patient diagnosed with MDIS presenting for transoral odontoidectomy and tracheostomy, wherein regional anesthesia techniques aided us in providing perioperative analgesia and maintaining hemodynamic stability.
Brain Abscess Drainage in a Case of Tetralogy of Fallot with Pulmonary Atresia with Major Aortopulmonary Collateral Arteries Under Scalp Block
Authors: Maddala Surya K. , Yadavilli Krishna P. , Das Prasanta K. , C. Vipin Chandran
Published: February 2024

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. There are a few reports of uncorrected TOF patients surviving into adulthood requiring noncardiac surgery. They are commonly susceptible to developing brain abscesses due to paradoxical embolism and lack of pulmonary phagocytic clearance. A 32-year-old man, a known patient of TOF with pulmonary atresia and major aortopulmonary collateral arteries, presented with left side weakness and seizures. He was drowsy with a Glasgow Coma Scale (GCS) of 13/15, heart rate of 72/min, oxygen saturation of 78% with 6 L/min oxygen via face mask, and blood pressure of 90/60 mm Hg with noradrenaline at 0.5 mcg/kg/min. He had central cyanosis, clubbing, and icterus. The left upper and lower limb power was 2/5, whereas it was 5/5 for the right. Cardiovascular examination revealed a grade 3/6 continuous murmur at the base of the heart. No pulmonary abnormality was noted on auscultation. Echocardiography showed large subaortic ventricular septal defect (VSD) with overriding of the aorta, pulmonary atresia, right-sided aortic arch, and ejection fraction of 62%. Magnetic resonance imaging (MRI) of the brain revealed features suggestive of brain abscess. Brain abscess drainage was performed under scalp block with sedation to avoid major hemodynamic fluctuations. The procedure was uneventful, and the patient's power on the left side improved postprocedure. Scalp block with sedation is a suitable alternative to general anesthesia for drainage of brain abscess in TOF patients.
Orthotopic Heart Transplant Recipient Presenting with Sudden Onset Homonymous Hemianopia
Authors: Chawnchhim Abraham L. , Sharma Neha , Goel Chetna , Mahajan Charu
Published: February 2024

Infectious complications are common among heart transplant recipients due to immune suppressive therapy mandatorily given to prevent organ rejection. We share our experience regarding an orthotopic heart transplant recipient who underwent craniotomy and evacuation of intracerebral abscess under general anesthesia in our operation theater. An orthotopic heart transplant recipient presented with headache, fever, and left-sided homonymous hemianopia. Noncontrast computed tomography (NCCT) of the head showed a right occipital space-occupying lesion suggestive of an abscess. Craniotomy and evacuation of abscess was successfully performed under general anesthesia. There are several concerns pertinent to orthotopic heart transplant recipients mainly due to denervated heart status and immune suppressive therapy, which poses perioperative challenge. We report successful anesthetic management of this case.
Surgical and Functional Outcome of Laparoscopic Vaginal Suspension Combined with Suture Rectopexy for Management of Pelvic Organ Prolapse
Authors: Abuelnasr Mohamed I. , Salama Ahmed M. F. , Nawar Ahmed M.
Published: February 2024

Purpose Laparoscopic techniques to treat pelvic organ prolapse are gaining popularity around the globe due to their low recurrence rates and better functional results compared to perineal techniques. However, the optimum surgical procedures are not yet determined. In the current research, we suggest a novel surgical approach, laparoscopic vaginal suspension with suture rectopexy, to treat multiorgan pelvic prolapse.

Methods This prospective cohort trial was conducted from March 2018 to March 2022 and comprised 35 females with multiorgan pelvic organ prolapse with obstructed defecation symptoms. A residual rectal prolapse was still present despite the manual reduction of uterine prolapse. Patients' conditions before and after the operation were monitored regarding the obstructed defecation score, sexual function, need for laxatives, anorectal manometry pressures, anorectal sensations, and recurrence. The mean follow-up duration was one year.

Results Modified Longo score for obstructed defecation significantly decreased at six and twelve months after surgery. Additionally, a significant reduction was reported in the number of patients who needed laxatives at six and twelve months after surgery. Anorectal manometry pre- and post-surgery showed a significant elevation in the mean squeeze pressure and a decline in all rectal sensations. All parameters of the female sexual function scoring system increased postoperatively. No recurrence was reported during follow-up.

Conclusion For multiorgan pelvic prolapse, laparoscopic vaginal suspension combined with suture rectopexy has excellent functional outcomes, minimal morbidity, and low cost.
Efficacy of Three Remineralizing Agents on Erosion of Root Dentin by Cola Drink: An In Vitro Study
Authors: Ratanachina Sirada , Pianmee Chawalid , Nantanapiboon Dusit , Poolthong Suchit
Published: February 2024

Objective The aim of the study was to investigate the effects of silver diamine fluoride (38% SDF), sodium fluoride (NaF) varnish, and casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) on cola-eroded root dentin microhardness and mineral alteration in vitro.

Materials and Methods Forty human root dentin slabs were exposed to alternating 10 cycles of cola drink and artificial saliva, repeated 3 times at 6-hour intervals. Specimens were randomly assigned to four groups: control (deionized water), 38% SDF, NaF varnish, and CPP-ACPF. All specimens underwent the second erosion process. Microhardness was measured at baseline (KHN0), pretreatment (KHN1), and posttreatment (KHN2). The mean difference of microhardness (ΔKHN2-1) was analyzed using one-way analysis of variance (ANOVA) and Tukey's post hoc tests (α = 0.05). The chemical composition and surface morphology were assessed using energy dispersive spectroscopy (EDS) and scanning electron microscope (SEM).

Results All experimental groups exhibited dentinal tubule occlusion. Both 38% SDF and NaF varnish demonstrated a statistically significant increase in microhardness compared to CPP-ACPF. However, CPP-ACPF was comparable to the control group. EDS analysis showed an increase in weight percentage of fluorine in all groups. Furthermore, silver and chlorine were detected in the 38% SDF group.

Conclusion All treatments enhanced eroded root dentin microhardness, with 38% SDF and NaF varnish demonstrating superior acid resistance and preventing morphological changes induced by cola re-immersion.
A New Radiological Scoring System as a Method of Assessing Sclerotherapy Treatment Response for Aneurysmal Bone Cysts: A Retrospective Study
Authors: Hussein Mohsin , Davies Mark , Hegde Ganesh , Azzopardi Christine , Patel Anish , James Steve , Botchu Rajesh
Published: February 2024

Background A widely accepted set of imaging criteria or classification has not yet been adopted to evaluate response to treatment by percutaneous sclerotherapy for aneurysmal bone cyst (ABC). In this article, we described and illustrated the Royal Orthopaedic Hospital (ROH) scoring system which is a new, reproducible, and objective tool to evaluate the radiological response. We also reported our institutional experience in the efficacy of computed tomography (CT)-guided sclerotherapy for treating such lesions.

Patients and Methods A retrospective analysis was conducted for 19 patients who underwent CT-guided sclerotherapy with doxycycline and albumin to treat ABC. Follow-up magnetic resonance imaging, at a minimum of 12 months, was assessed according to the four ROH scoring system parameters: cystic component, fluid–fluid level, presence of consolidation, and cortical integrity. The cumulative score was used to grade response as either: excellent, good, equivocal, or poor.

Results Out of 19 patients with a mean age of 17.8 years, 11 cases occurred in the long bones, 5 cases in the pelvis, and 1 in each of the C3 vertebral body, scapula, and talus. The mean parameter of response score for cystic component was 2, fluid–fluid level was 1.3, consolidation was 2, and cortical integrity was 2.1. Four cases showed excellent response, 12 cases showed good response, 2 cases showed equivocal response, and 1 case showed poor response. Interrater reliability was excellent (κ = 0.9).

Conclusion The ROH scoring system provides the radiologist and surgeon with an objective method to score imaging parameters of response independently and achieve a grade based on the cumulative score.
Assessment of Carotid Plaque Enhancement on Contrast-Enhanced Ultrasound as a Predictor for Severe Coronary Artery Disease
Authors: Agarwal Vanshika , Sherwani Poonam , Chauhan Udit , Kumar Barun
Published: February 2024

Background and Aim Contrast-enhanced ultrasound (CEUS) can reliably identify vulnerable plaques. As atherosclerosis is a systemic disease, we evaluated whether contrast enhancement of carotid plaque (CECP) can predict severe coronary artery disease (CAD) by comparing CECP in patients who have had acute coronary syndromes (ACS) recently with asymptomatic individuals.

Settings and Design This case–control study was done at a tertiary care center during 2022.

Materials and Methods Fourteen participants were recruited in each group, after screening in-patients for carotid plaques and inclusion and exclusion criteria. Those who had history of ACS were enrolled as cases, while those who did not were enrolled as controls. All these patients underwent grayscale, Doppler, and CEUS examination for characterization of the carotid plaque. For cases, findings on CEUS were also compared with the severity of CAD on catheter coronary angiography.

Statistical Analysis Diagnostic parameters including sensitivity, specificity, and diagnostic accuracy were calculated and proportions were compared by using Fisher's exact test.

Results Eight out of 28 patients showed CECP. CECP and CAD were positively associated with p-Value of 0.033. Eighty-three percent patients with triple vessel disease and 50% patients with double vessel disease on coronary angiography showed CECP. Sensitivity and specificity of CECP for prediction of CAD were 50 and 92.9%, respectively.

Conclusion CECP on CEUS can predict CAD and is a more reliable indicator of severe CAD than plaque characteristics on grayscale and Doppler imaging; making it useful for screening of patients at risk of having CAD.
Women's Performance in Conferences and Their Publications: A Critical Analysis
Authors: Samartine Junior Hugo , Gracitelli Giovanna Bertazzola , Mazzini Lucas Rosasco , Silva Lauro Igor , Levy Nicole Goldenberg , Aquino José Luis Braga de , Mendes Elisa Teixeira
Published: February 2024

Introduction Gender inequality occurs in all spheres of society, which is no different in the medical field. Abstract presentations in congress are the vanguard of scientific knowledge, an integral part of topic discussion, and, ideally, culminate in the publication of these works as complete manuscripts.

Objective The objective of this study is to evaluate the role played by women in the presentation of scientific works at the Brazilian Society of Coloproctology congress and in the works published from these presentations.

Methods The bibliometric evaluation of the presented abstracts in the editions from 2015 to 2018 of the Brazilian Congress of Coloproctology was used, along with the works later published from these presentations. Gender identification data was extracted from the authors of the abstracts through their names and research for conference on the Lattes and Google Scholar platforms. The collected data was on the number of female participants and their order of authorship of abstracts and publications, evaluating possible changes when publication occurs.

Results A total of 1,336 abstracts were analyzed, with 91.6% of female authors. When publication occurs, women's presence dropped to 75.2% and suffered a change of order in the position of authorship to one of lesser relevance in 38.1%.

Conclusion Women's participation occurs in most abstracts. However, this proportion undergoes unfavorable changes when these works are published, either by changing the order of authorship, when women leave main positions and become coauthors, or are removed from the complete manuscript's publication.
Pretherapeutic PSMA PET-Derived Semiquantitative Parameters as Predictors of PSA Response in Patients with mCRPC Receiving [177Lu]Lu-PSMA-617 Radioligand Therapy
Authors: Siripongsatian Dheeratama , Jantarato Attapon , Promteangtrong Chetsadaporn , Kunawudhi Anchisa , Kiatkittikul Peerapon , Boonkawin Natphimol , Yaset Sukanya , Somboon Sirinsuda , Chotipanich Chanisa
Published: February 2024

Objective [177Lu]Lu-prostate-specific membrane antigen (PSMA)-617 radioligand therapy (RLT) shows promise for metastatic castration-resistant prostate cancer (mCRPC) patients with positive PSMA positron emission tomography (PET) imaging. Identifying high-risk patients is crucial. We evaluated pretherapeutic PSMA PET-derived parameters to predict prostate-specific antigen (PSA) response in patients undergoing [177Lu]Lu-PSMA-617 RLT.

Materials and Methods We conducted a retrospective analysis among 27 patients (mean age: 71.0 ± 9.5 years; range: 52–85 years) who underwent PSMA PET/computed tomography (CT) and subsequent [177Lu]Lu-PSMA-617 RLT between March 2019 and January 2023. After excluding patients with liver metastases, the number of patients left for analysis was 21 (14 responders and 7 nonresponders). Tumors were semiautomatically delineated with calculation of total tumor volume (PSMA-TV), lesion uptake (PSMA-TLU = PSMA-TV * standardized uptake value [SUV]mean), and lesion quotient (PSMA-TLQ = PSMA-TV/SUVmean) for each patient. Semiquantitative parameters were analyzed only in patients with mCRPC and no liver metastasis.

Results In total, 17/27 patients (62.96%) had a decline in PSA levels; 15/27 patients (55.56%) experienced a decline of > 50%. Pretherapeutic PSMA PET/CT results revealed significant differences in PSMA-TV (p = 0.003), PSMA-TLU (p = 0.013), and PSMA-TLQ (p = 0.011) between responders and nonresponders. SUVmax was significantly correlated to the best percentage change in PSA response after 177Lu-PSMA-617 treatment (r = −0.79, p = 0.006). No association was observed between PSMA-TV (p = 0.367), PSMA-TLU (p = 0.128), and PSMA-TLQ (p = 0.556), with the best percentage change in PSA response after 177Lu-PSMA-617 therapy.

Conclusion Pretherapeutic PSMA PET-derived PSMA-TV, PSMA-TLU, and PSMA-TLQ were significant negative predictors of PSA response in patients with mCRPC and no liver metastasis receiving [177Lu]Lu-PSMA-617 RLT.
Evaluation of Gynecologists‧ Knowledge and Awareness Regarding Oral Health Condition During Pregnancy in the City of Benghazi, Libya
Authors: Garoushi Ibrahim H. , Bayou Kheiria M. , Eldfeir Randah , Bengdara Asala , Abushiha Malak , Ali Nada Ben
Published: February 2024

Background A pregnant woman with dental issues may not see a dentist unless her gynecologist advices her to do so. Thus, gynecologists need to be aware of the impact of dental health on pregnancy and what pregnant women need to do to improve their dental health.

Aim The aim of this study is to evaluate gynecologists' awareness, understanding, and practice regarding the impacts of dental therapy during pregnancy and the influence of dental disease on pregnancy outcomes.

Methods All the data in this cross-sectional study were acquired from gynecologists in public and private hospitals in Benghazi, Libya, over a period of 6 months during 2022. A modified structured questionnaire developed by Paneer et al consisting of 20 closed-ended questions related to oral care of pregnant patients was given to the participating gynecologists. Data obtained were presented as frequencies and percentages using the SPSS statistical package.

Results Sixty gynecologists, with ages ranging from 35 to 65 years, completed the questionnaire. The majority (81%) recognized that pregnancy increases the risk of gingival inflammation, but only 60% attributed this to hormonal changes. While 45% were aware of the impact of periodontal inflammation on pregnancy outcomes, only 38.3% knew about its association with preterm birth and low birth weight. Most participants (83%) considered dental referral important, and 81.7% believed oral cavity examination should be a part of maternal health, yet only 36% actually performed it. Ninety percent of the participants reported that they advise pregnant women on oral hygiene and routine checkups. Regarding safety, only 46.7% believed radiographs to be safe during pregnancy, and 51.7% considered local anesthesia with vasoconstriction safe. However, 95% agreed that the second and third trimesters are the safest period for dental treatment.

Conclusion The results of the current study show that gynecologists are fairly knowledgeable about the link between dental health and pregnancy. There is, however, unquestionably some miscomprehension about offering dental care to expectant mothers. Pregnant women and the medical community need access to more information, and misconceptions about suitable dental procedures during pregnancy must be addressed to improve oral health care.
MPIG6B Gene-Related Myelofibrosis: A Rare Inherited Disease That Is Frequently Described in Arab Population
Authors: Attar Leen Jihad , Alelaimat Almothana , Alshorman Alaa , Aladily Tariq N.
Published: February 2024

The megakaryocyte and platelet inhibitory receptor gene G6P (MPIG6B) is located on chromosome 6p21.33. It encodes G6b-B; an inhibitory receptor expressed on the surface of platelets. It regulates platelets production, aggregation, and activation. We describe a case of a 31-year-old man who presented with a long history of thrombocytopenia, anemia, and hepatosplenomegaly. The patient received multiple blood transfusions and his clinical course was stable. A bone marrow biopsy showed morphologic features similar to primary myelofibrosis. Whole exome sequencing study was performed and revealed homozygous pathogenic mutation in exon 2 of MPIG6B gene (c.324C > A, p.Cys108Ter) that is the second reported case in literature. In this report, we describe the main clinical and pathologic features of this disease and review the literature of previously documented cases.
Effect of Medial Opening Wedge and External Rotational Humeral Osteotomies on Medial Elbow Compartment Pressure: An Ex Vivo Study
Authors: Crystal Ed , Brettle Alice , Maddox Thomas W. , Jones Dan , Walton Myles Benjamin
Published: February 2024

Objective The aim of this study was to assess if the level of osteotomy (50 or 75% the length of the humerus), osteotomy angle (5, 10, or 20 degrees), direction of bone alteration (external rotational or medial opening wedge osteotomies), or orientation of osteotomy (perpendicular to the humeral long axis or perpendicular to the weight-bearing axis of the limb) affect pressure through the medial compartment of the elbow.

Study Design Humeral osteotomies were performed at 50 and 75% the length of the humerus on 12 canine cadaver thoracic limbs and patient-specific three-dimensional (3D) printed plates applied to induce the desired alteration. Sensors were placed into the medial and lateral aspects of the elbow joint and the limb compressed to 90 N in a universal testing system.

Results Increasing the angle of the induced change had a significant effect on the decreased load through the medial compartment. Performing the osteotomy at 75% of humeral length from proximal was significantly more effective at reducing the medial elbow load than performing it at 50%. Opening wedge osteotomies were more effective than external rotational osteotomies, but both were effective. Changing the direction of the osteotomy (comparing transverse to oblique) did not significantly affect the load reduction through the medial compartment.

Conclusion Performing an osteotomy at a more distal location along the humerus and increasing the angle of the induced change increased the effectiveness of load-shifting humeral osteotomies.
Performance dispersion among target date funds
Authors: Pavlova Ivelina , Hibbert Ann Marie
Published: February 2024

There are significant differences in the performance of Target Date Funds (TDFs) with the same target year. Using a unique dataset from Morningstar, we show that within the same target year, funds with lower than the average expense ratio, or higher than average allocation to equities, outperform similar funds. This outperformance exists across all target year groups and is economically meaningful. Furthermore, deviations in the equity allocation have a greater impact on performance than does expense ratio. Using bootstrap simulations to investigate the impact over a longer horizon, we show that deviations from the average allocations or expense ratios have a meaningful impact on the retirement savings of an average investor.
The regional powers research program: a new way forward
Authors: Prys-Hansen Miriam , Frazier Derrick
Published: February 2024

This introduction to our special issue on Revisiting Regional Powers examines ways in which the study of regional powers can enhance our ability to understand the dynamic nature of the international system today. The article, first, summarizes and highlights how the study of regional powers remains relevant to the broader discipline of international relations but also indicates that there remains much to improve and investigate, for instance by more systematically including less traditional issue areas for regional power engagement, including the environment or public diplomacy, by integrating disciplines beyond IR, including sociological and linguistic approaches. In today’s shifting global order, researching regional powerhood is needed for a better understanding of the emergence of order(s); by highlighting, for example, less-than-global forms of cooperation and conflict, and their often-complex simultaneities. We highlight the need to investigate forms of power beyond increases in military and economic power, but also to expand the types of actors beyond the state that we consider taking on functions of regional powerhood.
The golden section in the art of ancient Greece: an anthropometric study of the young warrior of Riace
Authors: Putrino Alessandra , Raso Mario , Marinelli Enrico , Caputo Martina , Zaami Simona
Published: February 2024

More than half a century after their discovery in the Ionian Sea near Riace Marina (Italy, 1972 CE), the Riace Bronzes continue to fascinate and interest. They are a pair of statues most likely sculpted in Greece in the mid-5th century and are considered masterpieces of Classical Greek sculpture. Many studies have been conducted, yet there are no morphometric studies that delve into their facial features. The aim of this study is to determine dentofacial characteristics and the presence of golden ratios in the so-called “young-man” warrior statue, equipped with a silver foil to represent the upper teeth. The interpupillar, interalar, intercanthal distances and mesio-distal diameter of the upper central incisors were subjected to virtual photogrammetry (GIMP-GNU Image Manipulation Programme). The presence of vertical and horizontal golden ratios between different landmarks (intercanthal distance: centre of the nose; centre of pupils: base of nose: base of upper incisors; centre of pupil-base of nose: base of upper incisors-base of chin; centre of pupils- base of upper incisors: base of the chin) were analysed using a dedicated software (PhiMatrix). The face and teeth satisfy most of golden canons, as also corroborated by the one-way ANOVA-statistic test (p < 0.05) for repeated measurements by independent expert operators. The virtual golden facial grid should confirm an ovoid face, which should match the same dental shape. The statue design stems from the search for beauty as divine proportion, and a relatively small detail such as teeth seems to have been carefully programmed.
Using design thinking for interdisciplinary curriculum design and teaching: a case study in higher education
Authors: Wang Chia-Chi
Published: February 2024

This study investigates the utilization of design thinking by a university instructor in the development and delivery of an interdisciplinary curriculum. It examines the challenges encountered and the coping strategies employed during the process. The research, conducted as a case study of an interdisciplinary program course at a university in southern Taiwan from September to December 2022, involved data collection through field observations, in-depth interviews, and document analysis. All data were transcribed verbatim, coded, and triangulated to enhance research validity. The findings suggest that design thinking serves as an effective methodology for interdisciplinary curriculum design and teaching. It emphasizes the integration of practice and application to facilitate students’ interdisciplinary collaboration and co-creation. Additionally, the study evaluates teaching strategies, with a focus on the role of visual tools, communication, and on-site observation. The insights gained from this research provide valuable perspectives on challenges in interdisciplinary teaching, particularly in a post-pandemic context. They guided the development of effective practices in Taiwan and beyond, addressing crucial aspects such as the roles of instructors, resource allocation, and the cultivation of interdisciplinary talent. The study emphasizes the continuous need for adaptation and the prioritization of depth in learning outcomes.
Quantum-enhanced super-sensitivity of Mach–Zehnder interferometer using squeezed Kerr state
Authors: Yadav Dhiraj , Shukla Gaurav , Sharma Priyanka , Mishra Devendra Kumar
Published: February 2024

We study the phase super–sensitivity of a Mach–Zehnder interferometer (MZI) with the squeezed Kerr state (SKS) and coherent state as the inputs. We discuss the lower bound in phase sensitivity by considering the quantum Fisher information and the corresponding quantum Cramér–Rao bound. With the help of single intensity detection, intensity difference detection, and homodyne detection schemes, we find that our scheme gives a better sensitivity under both lossless and lossy conditions as compared to the well–known results of the combinations of inputs, such as coherent plus vacuum, coherent plus squeezed vacuum, and double coherent states. Because of the possibility of the generation of SKS with the present available quantum optical techniques, we expect that SKS may be an alternative nonclassical resource for the improvement in the phase super–sensitivity of the MZI in realistic scenarios.
Time-reversible and fully time-resolved ultra-narrowband biphoton frequency combs
Authors: Chang Kai-Chi , Cheng Xiang , Sarihan Murat Can , Wong Chee Wei
Published: February 2024

Time-reversibility, which is inherent in many physical systems, is crucial in tailoring temporal waveforms for optimum light–matter interactions. Among the time-reversible atomic systems, narrowband biphoton sources are essential for efficient quantum storage. In this work, we demonstrate time-reversed and fully time-resolved ultra-narrowband single-sided biphoton frequency combs with an average free-spectral range (FSR) of 42.66 MHz and an average linewidth of 4.60 MHz in the telecommunication band. We experimentally observe the fully time-resolved and reversible temporal oscillations by second-order cross correlation and joint temporal intensity measurements. The potential benefits of the time-reversed and fully time-resolved temporal oscillations from our source include enhancing the efficiency of quantum storage in atomic memories and maximizing the utilization of temporal information in multimode biphoton frequency combs. We further verify the heralded single-photon state generation from the multimode biphoton frequency combs by using Hanbury Brown and Twiss interference measurements. To the best of our knowledge, this 42.66 MHz FSR of our photon-pair source represents the narrowest among all of the different configurated biphoton sources reported to date. This ultra-narrow FSR and its 4.60 MHz linewidth provide the highest frequency mode number of 5786 and the longest coherence time among all the singly configurated biphoton sources so far. Our time-reversed and fully time-resolved massive-mode biphoton source could be useful for high-dimensional quantum information processing and efficient time–frequency multiplexed quantum storage toward long-distance and large-scale quantum networks.
Open hardware solutions in quantum technology
Authors: Shammah Nathan , Saha Roy Anurag , Almudever Carmen G. , Bourdeauducq Sébastien , Butko Anastasiia , Cancelo Gustavo , Clark Susan M. , Heinsoo Johannes , Henriet Loïc , Huang Gang , Jurczak Christophe , Kotilahti Janne , Landra Alessandro , LaRose Ryan , Mari Andrea , Nowrouzi Kasra , Ockeloen-Korppi Caspar , Prawiroatmodjo Guen , Siddiqi Irfan , Zeng William J.
Published: February 2024

Quantum technologies, such as communication, computing, and sensing, offer vast opportunities for advanced research and development. While an open-source ethos currently exists within some quantum technologies, especially in quantum computer programming, we argue that there are additional advantages in developing open quantum hardware (OQH). Open quantum hardware encompasses open-source software for the control of quantum devices in labs, blueprints, and open-source toolkits for chip design and other hardware components, as well as openly accessible testbeds and facilities that allow cloud-access to a wider scientific community. We provide an overview of current projects in the OQH ecosystem, identify gaps, and make recommendations on how to close them at present. More open quantum hardware would accelerate technology transfer to and growth of the quantum industry and increase accessibility in science.
Shallow unitary decompositions of quantum Fredkin and Toffoli gates for connectivity-aware equivalent circuit averaging
Authors: M. Q. Cruz Pedro , Murta Bruno
Published: February 2024

The controlled-swap and controlled-controlled-not gates are at the heart of the original proposal of reversible classical computation by Fredkin and Toffoli. Their widespread use in quantum computation, both in the implementation of classical logic subroutines of quantum algorithms and in quantum schemes with no direct classical counterparts, has made it imperative early on to pursue their efficient decomposition in terms of the lower-level gate sets native to different physical platforms. Here, we add to this body of literature by providing several logically equivalent circuits for the Toffoli and Fredkin gates under all-to-all and linear qubit connectivity, the latter with two different routings for control and target qubits. Besides achieving the lowest cnot counts in the literature for all these configurations, we also demonstrate the remarkable effectiveness of the obtained decompositions at mitigating coherent errors on near-term quantum computers via equivalent circuit averaging. We first quantify the performance of the method in silico with a coherent-noise model before validating it experimentally on a superconducting quantum processor. In addition, we consider the case where the three qubits on which the Toffoli or Fredkin gates act nontrivially are not adjacent, proposing a novel scheme to reorder them that saves one cnot for every swap. This scheme also finds use in the shallow implementation of long-range cnots. Our results highlight the importance of considering different entangling gate structures and connectivity constraints when designing efficient quantum circuits.