bluuebunny/crossref_metadata_2025 huggingface dataset:
A Retrospective Analysis of the Significance of Serum Bilirubin Levels and Glycemic Measurements in Type 2 Diabetes Management in a Cohort of Patients in a Tertiary Care Hospital
Authors: Kariyawasan Chitranga Chysanthi , Kariyawasan Chitranga Chysanthi , Balasuriya Balasuriya Lekamlage Thushara , Ranatunga Sondapperuma Arachchige Charith Dakshitha , Dissanayake Dissanayake Mudiyanselage Champika , Herath Singappuli Ralalage Gemunu Priyantha
Published: October 2021

BackgroundIn type 2 Diabetes Mellitus (T2DM) chronic hyperglycemia leads to multi-organ damage. It is a chronic low-grade inflammation resulting in reduced antioxidants leading to many complications. Hyperglycemia causes glycation of serum proteins forming advanced glycation end products (AGEs). HBA1c is an AGE of haemoglobin. Bilirubin considered a waste product of the heme catabolic pathway, has proven to be a natural antioxidant associated with a lower prevalence of oxidative stress-mediated diseases. Bilirubin prevents glycation of proteins providing benefit in T2DM. General objective - To evaluate the association of serum bilirubin levels with HBA1c, FBS, PPBS in diabetes patients. Specific objectives - 1) To compare the serum bilirubin levels in diabetes patients with good and poor control. 2) To evaluate the association of HbA1c with FBS, PPBS and age in controlled and uncontrolled diabetes mellitusMethodology -A retrospective analytical study done at the department of Haematology of the Sri Jayewardenepura General Hospital.Sample selection and sample size -A random sampling technique used. Data obtained through laboratory information system of 201 adult patients diagnosed with T2DM. The study population grouped as poorly and well controlled using HbA1c value over and below 7% respectively. Normal ranges for serum bilirubin, FBS and PPBS was (0.3-1.2) mg/dl, (75- 110) mg/dl and (80-140) mg/dl respectively. Data were entered and analyzed using statistical package for social sciences (SPSS) version 20. Descriptive statistics used to calculate the median, mean and the standard deviation of age, serum bilirubin, HBA1c, FBS, and PPBS. Correlations between variables were done using Pearson’s Correlation method. The p value <0.05 was considered as statistically significant. Comparison of two diabetic groups were done using independent sample t test.Results. A negative correlation between total bilirubin and HbA1c (r = -0.234, p value = 0.001) with a low linear relationship (R Sq of 0.055, figure 02) observed. No statistical significance between total bilirubin level with FBS, PPBS and age (p value >0.05) but the mean values of these in the two groups were statistically significant (p value < 0.05). A statistically positive co-relation observed between HbA1c with FBS and PPBS, not with age. Conclusion. The significant negative correlation between total bilirubin and HbA1c, infers that a lower blood glucose level will result in reducing the oxidant stress mediated damage by the antioxidant and anti- inflammatory action of the increased oxygen free radicals produced by a high bilirubin.
Knowledge discovery and dengue forecasting applied in a four-year dataset collected at Natal/RN – Brazil
Authors: Sanchez-Gendriz Ignacio , Fountuora Gustavo , de Andrade Ion , Neto Adrião Duarte Doria , Tavares Alessandre de Medeiros , Barros Daniele , de Morais Antonio Higor Freire , Galvão-Lima Leonardo J. , Valentim Ricardo Alexsandro de Medeiros
Published: October 2021

Dengue is recognized as a health problem, it causes significant impacts on health worldwide, affecting millions of people each year. A useful method of dengue vector surveillance is to count Aedes aegypti eggs deposited in spatially distributed ovitraps. The present work uses a database collected in 397 ovitraps distributed in the municipality of Natal/RN – Brazil. The number of eggs in each ovitrap was counted weekly, for four years (2016 - 2019) and was analyzed jointly with the dengue incidence in the same period. Our results confirms that dengue incidence seems to be related to socioeconomic status on Natal’s municipality. Using a deep learning model, we predict the incidence of new dengue cases based on data obtained from the previous week of dengue or in the number of eggs present in the ovitraps. The analysis shows that ovitrap data allows earlier detection (4-6 weeks) than dengue cases itself (1 week). The results confirm that quantifying Aedes aegypti eggs can be valuable for planning health actions.
Colorimetric Immunological Paper-based Assay for Exosome Detection
Authors: Kasetsirikul Surasak , Shiddiky Muhammad J.A. , Nguyen Nam-Trung
Published: October 2021

This paper reports the development of colorimetric immunological paper-based assay for exosome detection. The paper-based device was fabricated with lamination technique for easy handling and create hydrophilic/hydrophobic region for analytical paper-based devices. Exosome-specific antibody was coated onto the paper-based devices as a biosensing platform to detect exosome sample from the cell culture media. This assay employed a colorimetric reaction which is followed by reaction between horseradish peroxidase (HRP) and 3,3’,5,5’-tetramethylbenzidine substrate (TMB). The colorimetric readout was qualitatively evaluated by naked eyes and was quantitatively assessed by image processing software. The result indicated that this assay faces many challenges. First, the exosome concentration may be inadequate to reach detectable range. Second, high background signal due to non-specific binding on the platform results in lack of sensitivity for exosome detection. Therefore, modification on the paper should promote protein binding for specific target and prevent non-specific binding to reduce the high background signal.
Conduction and Resistive Switching Memory in Al/MoS2+PVP/Ag Devices Fabricated using Drop cast Method
Authors: Dlamini Zolile Wiseman , Vallabhapurapu Sreedevi , Mahule Tebogo Sfiso , Wu Shuying , Vallabhapur Vijaya Srinivasu
Published: October 2021

Resistive switching in MoS2 embedded PVP composite-based ReRAM with Al and Ag electrodes is reported. A cost-free drop cast method was used to deposit active layers consisting of 30 wt%, 40 wt%, and 70 wt% of MoS2 in PVP. Each system exhibited unique electroforming and switching mode. Asymmetrical bipolar resistive switching occurring only in the positive voltage bias, a typical bipolar resistive switching and a typical ‘O-type’ resistive switching were observed for the 30 wt%, 40 wt%, and 70 wt% systems, respectively. Furthermore, injection of charge carriers at the electrode/active layer interface and electrochemical metalization mechanisms drove the formation of a nanoscale conductive filament in the device A and B. On the other hand, we attributed the conduction mechanism of device C to hopping conduction. Our results demonstrate the behaviour of MoS2 embedded PVP composite-based ReRAM has a strong dependence on the amount of MoS2 and that both the switching and conduction mechanism can be exploited by controlling the amount of MoS2 in the composite.
Altermagnetism: spin-momentum locked phase protected by
non-relativistic symmetries
Authors: Jungwirth Tomas , Šmejkal Libor , Sinova Jairo
Published: October 2021

The search for novel magnetic quantum phases, phenomena and functional materials has been guided by relativistic magnetic-symmetry groups in coupled spin and real space from the dawn of the field in 1950s to the modern era of topological matter. However, the magnetic groups cannot disentangle non-relativistic phases and effects, such as the recently reported unconventional spin physics in collinear antiferromagnets, from the typically weak relativistic spin-orbit coupling phenomena. Here we discover that more general spin symmetries in decoupled spin and crystal space categorize non-relativistic collinear magnetism in three phases: conventional ferromagnets and antiferromangets, and
a third distinct phase combining zero net magnetization with an alternating spin-momentum locking in energy bands, which we dub "altermagnetic". For this third basic magnetic phase, which is omitted by the relativistic magnetic groups, we develop a spin-group theory describing six characteristic types of the altermagnetic spin-momentum locking. We demonstrate an extraordinary spin-splitting mechanism in altermagnetic bands originating from a local electric crystal field, which contrasts with the conventional magnetic or relativistic splitting by global magnetization or inversion asymmetry. Based on first-principles calculations, we identify altermagnetic candidates ranging from insulators and metals to a parent crystal of cuprate superconductor. Our results underpin emerging research of quantum phases and spintronics in high-temperature magnets with light elements, vanishing net magnetization, and strong spin-coherence.
Testing olfaction in equids: Age and gestational stage affects olfactory interest
Authors: Rørvang Maria Vilain , Nicova Klára , Yngvesson Jenny
Published: October 2021

In spite of the highly developed olfactory apparatus of horses, implying a high adaptive value, research on equine olfaction is sparse. Our limited knowledge poses a risk that horse behaviour does not match human expectations. The benefit of acquiring more knowledge of equine olfaction is therefore twofold; 1) it can aid the understanding of horse behaviour and hence reduce the risk of dangerous situations, and 2) there may be unexploited potential of using odours in several practical situations where humans interact with horses. This study investigated olfactory abilities of, 35 Icelandic, horses who were presented to four odours: peppermint, orange, lavender and cedarwood. The response variables were sniffing duration per presentation and behavioural reaction (licking, biting, snorting, and backing). Results showed horses were able to detect and distinguish between all four odours and showed increased interest (significantly longer sniffing duration) for peppermint. More horses expressed licking behaviour when presented to peppermint compared to cedarwood and lavender. Young horses sniffed cedarwood for longer than old horses, and pregnant mares sniffed lavender less than non-pregnant mares. In conclusion, the test paradigm seemed meaningful for horses, and olfactory interest of horses varied with age and gestational status but not sex.
Real-world data suggests that CGRP inhibitors improve onabotulinumtoxinA efficacy for chronic migraine
Authors: Blumenfeld Andrew M , Frishberg Benjamin M , Schim Jack D , Iannone Ashley , Schneider Gary , Yedigarova Larisa , Adams Aubrey Manack
Published: October 2021

The authors have requested that this preprint be removed from Research Square.
Physiological responses of Holstein calves to prolonged heat stress and dietary supplementation with a postbiotic from Aspergillus oryzae
Authors: Ríus A. G. , Kaufman J. D. , Ipharraguerre I. R. , Li M. M. , Hanigan M. D.
Published: October 2021

Increased ambient temperature causes heat stress in mammals, which affects physiological and molecular functions. We have recently reported that the dietary administration of a postbiotic from Aspergillus oryzae (AO) improves tolerance to heat stress in fruit flies and cattle. Furthermore, heat-induced gut dysfunction and systemic inflammation have been ameliorated in part by nutritional interventions. The objective of this study was to characterize the phenotypic response of growing calves to long-term heat stress compared to thermoneutral ad libitum fed and thermoneutral feed-restricted counterparts and examining the physiologic alterations associated with the administration of the AO postbiotic to heat-stressed calves with emphasis on intestinal permeability. In this report, we expand previous work by first demonstrating that heat stress reduced partial energetic efficiency of growth in control (45%) but not in AO-fed calves (62%) compared to thermoneutral animals (66%). While heat stress increased 20% the permeability of the intestine, AO postbiotic and thermoneutral treatments did not affect this variable. In addition, AO postbiotic reduced fecal water content relative to thermoneutral and heat stress treatments. Heat stress increased plasma concentrations of serum amyloid A, haptoglobin and lipocalin-2, and administration of AO postbiotic did not ameliorate this effect. In summary, our findings indicated that heat stress led to reduced nutrient-use efficiency and increased systemic inflammation. Results suggest that the AO postbiotic improved energy-use efficiency, water absorption, and the intestinal permeability in heat stress-mediated increase in gut permeability but did not reduce heat stress-mediated rise in markers of systemic inflammation.
To Find the Rapid Method of Vermicomposting
Authors: Kholiya Deepak , Poudel Gobinda
Published: October 2021

Vermicomposting is the scientific method of making compost by using earthworms. It is the cheap and effortless way for producing the organic compost. vermicompost is a backbone for enhancing the organic movement. the research was carried out in the kapilvastu district Nepal under the direction of Dr. Deepak kholiya (A professor of Graphic era hill university).to see the rapid method of vermicomposting and to use animal waste such as cow dung in the effective manner. Eisenia foetida an species of earthworm was used for the conversion of animal waste into the compost. In research we used two methods of vermicomposting i.e.,1. Pit method of size 5*5*3 feet 2. Bed method of size 6*2*2 feet. 200earthworms of same size were introduced in the both methods i.e., body length 3-10 cm body weight 0.4 to0.6 g. The substrate used in vermicomposting is rice straw along with chopped vegetable waste are mixed with the cow dung. Vermicompost sample of both methods are collected. Compost from bed method was collected after 60 days (about 2 months) and pit method was collected after 30-35 days (about 1 month 4 and a half days). both the vermicompost sample were high in nutrient content.
The Impact of Financial Ratios on the Dividend Payout Ratio in Coal Mining Companies
Authors: Sebastian Aldo , Siauwijaya Rahmat
Published: October 2021

The purpose of this study is to determine the impacts of current ratio, debt to equity ratio, return on asset, total asset turnover ratio, and working capital turnover ratio on the dividend payout ratio in coal mining companies listed in Indonesia Stock Exchange 2016-2018. The sample used in this study was determined based on a purposive sampling method. The type of data used in this study is secondary data and the technique used to analyze the data in this study is panel data regression analysis.

The results show that the debt to equity ratio has a negative and significant effect on the dividend payout ratio. While, current ratio, return on asset, total asset turnover ratio, and working capital turnover ratio have no significant effect on the dividend payout ratio.
Increasing the Selling Value of Indonesian Cultural Products to the Global (Case study of Batik as Indonesian Cultural Identity)
Authors: Limano Ferric
Published: October 2021

Culture consists of practices, objects, and values ​​in one society. This culture occurs as a result of the emergence of transactions and agreements between certain communities so as to agree on these existing values ​​into the daily life. Even this culture itself is passed down from generation to generation, the identity of this culture demands uniqueness, boundaries, and originality. But the big problem is the strong current of globalization which makes the mingled interactions between one and another culture. Indonesia is rich in culture, which in the past also experienced a lot of acculturation with one another. The uniqueness of Indonesian culture is displayed in many forms, both objects and habits, including performing arts in Bali, phinisi ships, and also batik. Through this research the authors again raise how to increase the selling value of cultural products in Indonesia, by looking at the case studies of traditional batik which innovated into a global approach. This case is discussed from the point of view of Komaruddin Kudiya's success in introducing batik to the global market. The research method was carried out qualitatively, with a cultural and business design approach. The data obtained is based on workshops and seminars, as well as literature obtained online. Furthermore, the data will be studied and analyzed descriptively to produce explanations related to the factors that increase the selling value of batik as a result of Indonesian culture.
Proses Komunikasi melalui Media Visual Fotografi sebagai Ilustrasi
Authors: Gunawan Agnes Paulina
Published: October 2021

Artwork generally contains a message or idea to be communicate to others as a viewer. From the various situations that can be captured in a visual appearance of the work of Photography, many things can be delivered into an idea that can have different meanings depending on the impression captured by the photographer and also depending on the interpretation of the viewer.

However, considering the work of Photography as a visual work in two-dimensional form, of course there are advantages and disadvantages of expressing ideas or meanings that the photographer might want to deliver, so maybe there is different perception, and not everybody can clearly understand the intent and impression the photographer means. Different interpretations from the photographer's point of view and the point of view of the observer are actually relatively reasonable, considering that each person with different emotional experiences and from different points of view can produce different reactions.

With the visual appearance of the photography work, many people use this visual information to explain some information. Either in articles, in stories, or in a work procedures or processes. So that the photo works will be a tool to support, to clear up and clarify information. This journal will discuss about photography as a visual media that support an information commonly known as Illustration Photography.
Description of Implementation of Self-Regulated Learning on Student at The University of X
Authors: Peranginagin Yan Andre , Sulaeman Budi , Wulandari Antonina Pantja Juni
Published: October 2021

This research aims to provide a description regarding the implementation of Self-Regulated Learning on students at the University of X. This research was organized with quantitative methods with types of descriptive. Sampling method on this research using the technique of convenience with the number of participants of 110 students of University consist of 48 males and 62 females. Measurement of Self-Regulated Learning conducted using questionnaires which done by researchers based on 3 phases of Self-Regulated Learning, which are: (1) Forethought, (2) Performance and (3) Self-reflection. The result of this research showed that applying on the first phases which is the stage of Forethought relatively low with the gain of score of 2.62 compared to an average score of 2.82. However, the second phases, which is the stage of performance relatively high with the gain of score above average which is 2.90. the implementation of the third phases which the self-reflection quite high with the score of 2.94. On the research also found the relationship between Grade Point Average (GPA) and the implementation of  the 3 phases of Self-Regulated Learning, which is the higher GPA score earned by students, the more optimal the implementation of 3 cycles of Self-Regulated Learning.
The Effect of Quality of Work Life, Hardiness and Perceived of Alternative Job Opportunities on Turnover Intentions
Authors: Setyawati Ira
Published: October 2021

Many behaviors that indicate turnover intentions in the company become a serious problem such as laziness to work, high absences, many employees do not renew their contracts, employee dissatisfaction with the company policies, high-level work stress, etc. This study aimed to examine the influence of quality of work life, hardiness, and perceived of alternative job opportunities on turnover intentions. This study method used is a quantitative method with the type of associative research. Data collection with questionnaire scale and sample of 167 employees. Data analysis uses multiple linear regression using SPSS version 26 for Windows software. This study found that quality of work life, hardiness, and perceived of alternative job opportunities together influenced turnover intentions by 57.8%. This study also provides an overview for companies to consider the aspects that may affect turnover intentions. The company needs to consider the market situations before implementing the new policies, doing employee surveys to know their perceptions, and improve the company systems to create a good work environment.
Evolution of Interpersona Communication Through Symbols (Sticker) Cyber Native In The Line App
Authors: Rachmawati Noor Aini , Salam Oryza Devi , Setiawan Giovani Anggasta , Izaak Regina Geovania Anggasita
Published: October 2021

The essence of man in life is to conduct communication activities. An individual is said to communicate with others if both have an understanding of the meaning of the message conveyed in his interaction. Advances in information communication technology provide opportunities for individuals to more easily interact over the internet. Of the recorded internet users, 130 million are active on social media. New Media Communication, or communication based on information technology, makes social media a prima donna for individuals to interact socially in cyberspace. Text-based communication platforms such as WhatsApp and LINE make it easier for individuals or those in cyberspace referred to as digital natives to interact. These digital natives in their interactions do the continuous thing as a habit that eventually becomes a culture of communication.

            In this research, the focus of research is the evolution of communication between users in the new media era in LINE users as a text application-based social media with a constructivist approach, qualitative research methodology with virtual ethnographic research methods and descriptive analysis levels. Data collection with online interviews, as well as chat history observations and the use of LINE sticker features. The purpose of the study is: (1) to find out the communication of digital natives on the LINE application platform, (2) to find out the evolution of interpersona communication formed from the results of native digital interactions on the LINE application platform using a virtual ethnographic approach.
Pengaruh Religiusitas, Agreeableness, dan Usia Terhadap Perilaku Prososial Remaja
Authors: Widiastuti Ika Maya
Published: October 2021

This study aims to examine the effect of religiosity, agreeableness, and age on adolescence’s prosocial behavior. This study selected the sample of 296 student, using a purposive sampling technique. The data collection used modification scale of Prosocialness Scale, Muslim Daily Religiosity Assessment Scale (MUDRAS), and International Personality Item Pool-Big Five Factors Model-50 (IPIP-BFM-50). Multiple regression and Confirmatory Factor Analysis (CFA) were performed to analyze the data. The finding showed there is a significant influence of religiosity, agreeableness, and age on prosocial behavior.
Damage Classification on Bridges using Backpropagation Neural Network
Authors: Tansil Victoria Ivy , Hanafiah Novita , Gunawan Alexander Agung Santoso , Suryani Dewi
Published: October 2021

Bridge structures can be damaged due to various factors such as pressure, vibration, temperature, etc. This study aims to detect damaged on bridges early so that accidents that can occur due to the damaged-on bridge can be avoided. The research method is divided into designing a model, building the model, and evaluating the model. The result of this research is a program that can classify healthy or damaged bridges using vibration data of tested points on bridges.
Extracts of the Native Brazilian Tree Garcinia gardneriana Inhibit Urediniospore Germination of Coffee Leaf Rust Fungus
Authors: da Silva Ueveton , Ferreira Bruno , de Sousa Bianca , Furlani Gabriela , Barreto Robert , Agrizzi Ana Paula , Leite João Paulo , dos Santos Marcelo , Varejão Eduardo
Published: October 2021

The fungal Hemileia vastatrix is the causal agent of coffee leaf rust, one of the worst and devastating disease in coffee cultures worldwide. As a result of our research on natural products for the development of novel agrochemicals, we found that the hexane extract from leaves of the Brazilian medicinal plant Garcinia gardneriana, at 500 μg mL–1, inhibited in 98% the germination of H. vastatrix urediniospores. This extract showed no phytotoxicity when tested for seed germination and seedling growth inhibitory activity using sensible plant species. Also, the hexane extract from leaves was tested for anti-acetylcholinesterase activity, which constitutes a mechanism of action of major commercial insecticides used in agriculture, and showed low activity even at concentrations about two times higher than the half maximal inhibitory concentration (IC50) found in the antifungal assays. Gas chromatography-mass spectrometry (GC-MS) analysis showed that the hexane extract is constituted mainly by the pentacyclic triterpene lupeol, together with a series of sesquiterpenes as minor components. This is the first report on the investigation of antifungal, phytotoxic and acetylcholinesterase activities of extracts from leaves of G. gardneriana. These findings indicate that G. gardneriana may constitute a promising source of natural products for controlling the coffee leaf rust fungus.
Educação e moralidade em Schopenhauer [Schopenhauer on education and morality]
Authors: Debona Vilmar
Published: October 2021

O objetivo do presente artigo é analisar a semântica atribuída por Schopenhauer à noção de educação no horizonte da sua metafísica da vontade. Trata-se de problematizar e mostrar as funções e a relevância que a educação exerce frente à distinção entre os planos da moralidade e da legalidade no âmbito da filosofia schopenhaueriana, mesmo que esta atribua uma natureza fixista ao caráter humano.
Resonancias emocionales de la razón en Kant [Emotional resonances of reason in Kant]
Authors: Sánchez Madrid Nuria
Published: October 2021

Este artículo se propone calibrar, partiendo del estado actual de la cuestión, las funciones que los sentimientos o emociones ejercen en todo el arco del proyecto crítico, afectando a la concepción del conocimiento y de la acción moral. Para ello, comenzaré analizando el sentido, no sólo retórico, del concepto kantiano de Bedürfnis, planteando sucesivamente la dimensión radical que el sentimiento de placer y displacer posee en el ánimo humano, la necesidad de que la virtud sea ejercida con un corazón alegre, siguiendo la enseñanza de Epicuro, y finalmente la conexión de la belleza con la resonancia afectiva que penetra todo el edificio de la reflexión. En la conclusión extraeré algunas consecuencias que un estudio de las Críticas en clave sentimental puede introducir en la concepción usual de la razón en Kant, ampliando los mecanismos de implantación en el mundo de esta facultad, al reconocer la importancia del sentimiento y la inclinación para la construcción de la autonomía humana.
A vida, os propósitos da natureza e por que as coisas no mundo existem [Life, purposiveness of nature and why do the things in the world exist]
Authors: Nahra Cinara Leite
Published: October 2021

O objetivo deste artigo é discutir e clarificar o papel do princípio reflexivo dos propósitos da natureza em Kant. Nossa intenção aqui é mostrar o papel estratégico deste princípio na filosofia de Kant a fim de reconciliar mecanismo e telos, causas eficientes e causas finais, dando uma explicação geral para a emergência da vida. Quando começamos a pensar como se a natureza tivesse propósitos é possível mesmo dar alguma explicação geral sobre como seres organizados são possíveis. A vida emerge porque a natureza tem um propósito e o propósito da natureza é criar vida (seres organizados), e especialmente criar a vida racional. Mostramos que para Kant devemos pensar como se os propósitos da natureza operassem subjacentemente a todo o mecanismo das leis naturais, dando unidade para todas estas leis e ordenando o sistema, mesmo não sendo possível provar isto.
A chave do segredo
Authors: Nahra Cinara Leite , Oliveira Carlos Moisés de
Published: October 2021

Resenha da obra: KANT, I. Primera Introducción de la Crítica del Juicio de Kant. Edición bilíngue. Trad. Nuria Sánchez Madrid. Madrid: Escolar y Maio, 2011.
Analítica e ontologia: sobre a teoria kantiana dos objetos [Analytic and ontology: on the Kantian theory of objects]
Authors: Bonaccini Juan Adolfo
Published: October 2021

No presente estudo defende-se uma interpretação "ontológica" da Crítica da razão pura. Especificamente, argumenta-se que a Analítica Transcendental apresenta uma "teoria dos objetos", a saber, uma teoria categorial que opera uma reconstrução meta-teórica da estrutura objetiva do nosso pensamento e da experiência do mundo a partir de uma reflexão sobre a estrutura formal de nossas faculdades cognitivas. Assim, em face de concepções que reduzem as categorias a meras funções lógicas, ou a condições epistêmicas, ou semânticas, argumenta-se que na verdade Kant as considera primordialmente como predicados ontológicos, na medida em que constituem a priori a estrutura da "objetualidade" das coisas, tornando possível pensar os "objetos" que compõem o inventário do mundo que podemos pensar e conhecer. Defende-se também que a epistemologia e a semântica estão contidas no projeto kantiano, mas pressupõem uma ontologia crítica enquanto meta-teoria dos objetos: dos "objetos" que só podemos pensar em geral; dos "objetos" que podemos pensar e também conhecer; e, finalmente, dos objetos que somente podemos pensar mediante predicados transcendentais, mas não podemos conhecer.
APPLICATION OF A MULTIDIMENSIONAL DETERMINISTIC-STATISTICAL NUMERICAL CORRELATION MODEL TO REFINE THE STRUCTURE OF THE AS11 HORIZON OF THE ZAPADNO-KAMYNSKOYE FIELD
Authors: NIKASHKIN Anatoly M. , KLIMOV Alexey A.
Published: October 2021

One of the primary and significant tasks in the construction of geological models of oil and gas reservoirs and development facilities is the problem of correlation of productive layers. This task, as a rule, is reduced to the identification and areal tracing of presumably even-aged oil and gas strata, horizons, and layers characterized by clear boundaries between sand strata and clay layers overlapping them. The practice of work related to modeling the structure of oil and gas horizons, layers and strata indicates that the correlation is not always unambiguous. The ambiguity is especially noticeable when correlating strata characterized by a clinoform structure, one of the examples is the Achimov strata. The most reliable basis for well correlation is GIS materials and lithological features of the interlayers forming individual layers. Clay interlayers and clay strata separating productive deposits provide valuable information when choosing a correlation model in sedimentary sections. These interlayers are characterized by the greatest consistency in area and are most clearly displayed on geophysical diagrams by the nature of the drawings of GIS curves. However, even in this case, i. e. when using the entire accumulated volume of the most diverse lithological and field-geophysical information, the correlation models of the sections turn out to be different and often even opposite. In this paper, the authors had to face a similar situation when correlating the horizon AS11 of the Zapadno-Kamynskoye field. The paper describes a method for clarifying the position of the chops of the productive horizon of oil and gas deposits using a multidimensional deterministic-statistical numerical model of the correlation of sedimentary strata. The proposed approach allows us to uniquely determine the positions of the chops in the conditions of a complex geological structure of the object, high thin-layered heterogeneity. A concrete example shows the advantages of the proposed approach in comparison with the traditional one.
Estimation of Flow Discharge Model at Temef Watershed - East Nusa Tenggara Using TRMM Satellite Data
Authors: Nomleni Aprianto , Suhartanto Ery , Harisuseno Donny
Published: October 2021

Data collection based on satellite TRMM (Tropical Rainfall Measuring Mission) presents one of the good alternatives in estimating rainfall. TRMM technology can minimize manual rainfall recording errors and improve rainfall accuracy for hydrological analysis. The analysis method used in this research is divided into 3 (three) stages, namely Hydrology analysis, Statistical Analysis and Artificial Neural Network Analysis. From the results of TRMM JAXA analysis in the Temef Watershed Area of East Nusa Tenggara Province obtained TRMM JAXA satellite rainfall relationship to observation data shows rainfall patterns between the two data are interconnected but for cases with very high observation rainfall, TRMM rainfall data tends to be low. From statistical method analysis, the relationship between observation rainfall and TRMM JAXA rainfall obtained results with a "Very Strong" interpretation indicated by the results of 9 years calibration and 1 year validation where the selected equation is a polynomial equation (y=-0,0123x2 + 1,5553x + 20,222). Rain data correction results simulated with Debit data to see the relationship between rain and discharge that occurred, this analysis using Artificial Neural Network with Backpropagation method, the results showed a "Strong" interpretation where statistically the value of Nash-Sutcliffe Efficiency (NSE) 0.920, the coefficient value of correlation of field discharge and TRMM rainfall is 0,877 % and the relative error occurred is 2,62%
Analysis of Cross-Sectional Capacity of the Jambi River in the Muaro Jambi Temple About Various Times of Flooding Using HEC-RAS Software
Authors: Mayasari Putri , Ilfan Freddy , Yasdi Yasdi , Rimba Rimba
Published: October 2021

Jambi River is one of the rivers located in the Muaro Jambi Temple Complex Area, Muaro Jambi Regency, Jambi Province. Muaro Jambi Temple is one of the tourist attractions in Jambi Province. This study aims to find the capacity of Jambi River tested by planned flood discharge utilizing (synthetic unit hydrograph) HSS Nakayasu method for a return period of two, five, ten, twenty-five, fifty and hundred years. HEC-RAS software used to analyse the water level in the Jambi River towards the flood potential that causes the submerging of the Kedaton Temple building. This research used the log Pearson type III method to calculate the planned rain return period and used the Nakayasu synthetic unit method to calculate the planned flood discharge. The analysis showed that the Jambi River could not load the flood discharge in the five, ten, twenty-five, fifty, and one hundred years return period at several measurement points: river sta-1, river sta-2 and river sta-5. The floodwater level did not cause the Kedaton Temple building to be flooded from the simulation result
Personal data protection and access to information: interfaces of Civil Society role in Brazilian legislative process
Authors: Farranha Santana Ana Claudia , Borsio Bataglia Murilo , Nunes Lopes Espiñeira Lemos Amanda
Published: October 2021

The relationship between access to information and personal data protection leads to the relativization of transparency under the argument of a false tradeoff between these two concepts. Based on that, this study’s objective is to understand the role of civil society movements in maintaining the rights of access to information and personal data protection. This research made a qualitative analysis, with a documentary survey and bibliographic review of the main categories presented in the Executive-Legislative relationship and in the theme of advocacy. We observe the role of civil society lobby groups in the Brazilian Access to Information Law legislative process, between 2003 and 2011, and the Brazilian Data Protection Act, between 2012 and 2018, perceive the change of these groups with the foundation of Rights in Network Coalition, in 2016. As a result, the active participation of Civil Society in public hearings has intensified increasingly in public hearings since 2018, specifically on the LGPD, while LAI had participation of civil society in the body’s scope institutionalized.
Local and regional power: its role in European Integration and the protection of the rule of law
Authors: De Lima Saraiva Bruno Miguel
Published: October 2021

A failure in administrative approximation, as established by the EU Treaties, tends towards the perpetuation of systems that keep an organisational statu quo favorable to the stagnation of European integration by limiting its spread beyond urban areas to rural areas. The phenomena of asymmetric economic development within Member States, in turn, allows for the maintenance of this organisational and integrative inertia in highly centralised Member States, serving as a one of the engines for the development of anti-EU sentiment and vote. In this sense the reasoning behind the establishment of local and regional power as a constitutional bulwark against the development of an illiberal or authoritarian list, especially in young democracies, becomes especially important when framed in context with the growth of authoritarian anti-EU movements throughout Europe. This growth, finding an eager bulwark in rural areas, is not coincidental and might be attributed to the distance from the decision-making process that local and regional government struggle with, combined with economic stagnation and difficulties in the use of resources and opportunities that are theoretically afforded by EU membership, leads to the development of anti-EU sentiment, offering political support and democratic legitimacy to projects which oppose the EU and prove detrimental to democratic systems. This paper therefore posits that to safeguard the development of the greater European project and democracy within Member States, there must be an expansion of the very same principles that govern the interactions between Member States and the EU to the subnational level, with a special focus on subsidiarity.
European Climate Law – real changes or postponed future?
Authors: Cardoso Ana , Abreu Amorim Carlos
Published: October 2021

One cannot question the scientific evidence of the deterioration of the planet’s environmental quality and the global climate emergency. The apparent growth of denialism in the climate debate does not bring anything positive. The European Green Deal (“EGD”) appeared as a consolidated strategy to fight climate change, but the world is not the same as it was in December 2019. Even before the COVID-19 crisis, there were doubts about the viability of such a powerful political and financial investment. As we try to deal with the fallout of the COVID-19 pandemic and guide our economies to recovery, risks of diversion or misuse of these environmental funds seemed possible. Fortunately, environmental common sense seems to have prevailed. In an unforeseen but potentially happy marriage, the Recovery Plan for Europe and the EGD were united in their purposes and in their concrete action. The European Climate Law (“ECL”) is the first binding legal instrument born of the EGD. With a non-mishap-free preparation process, the final version provokes contradictory feelings. First, the perception that one could have gone further is inescapable. On the other hand, what is already acquired is relevant and Europe is unlikely to go back on this essential matter. There are innovations in the ECL that significantly altered the Commission’s original proposal, introducing new elements. But while some of these changes appear to have been forced by the new circumstances, others may be proof that Member States do not have the same predisposition to deal with the objectives of the EGD and the fight against climate change. The safest way to contradict this inclination is to strengthen the ECL as a key tool in the implementation of the European Union’s environmental and policy strategy.
A Novel Virtual Reality Assessment of Functional Cognition: Validation Study
Authors: Porffy Lilla Alexandra , Mehta Mitul A , Patchitt Joel , Boussebaa Celia , Brett Jack , D’Oliveira Teresa , Mouchlianitis Elias , Shergill Sukhi S
Published: October 2021

Background

Cognitive deficits are present in several neuropsychiatric disorders, including Alzheimer disease, schizophrenia, and depression. Assessments used to measure cognition in these disorders are time-consuming, burdensome, and have low ecological validity. To address these limitations, we developed a novel virtual reality shopping task—VStore.

Objective

This study aims to establish the construct validity of VStore in relation to the established computerized cognitive battery, Cogstate, and explore its sensitivity to age-related cognitive decline.

Methods

A total of 142 healthy volunteers aged 20-79 years participated in the study. The main VStore outcomes included verbal recall of 12 grocery items, time to collect items, time to select items on a self-checkout machine, time to make the payment, time to order coffee, and total completion time. Construct validity was examined through a series of backward elimination regression models to establish which Cogstate tasks, measuring attention, processing speed, verbal and visual learning, working memory, executive function, and paired associate learning, in addition to age and technological familiarity, best predicted VStore performance. In addition, 2 ridge regression and 2 logistic regression models supplemented with receiver operating characteristic curves were built, with VStore outcomes in the first model and Cogstate outcomes in the second model entered as predictors of age and age cohorts, respectively.

Results

Overall VStore performance, as indexed by the total time spent completing the task, was best explained by Cogstate tasks measuring attention, working memory, paired associate learning, and age and technological familiarity, accounting for 47% of the variance. In addition, with λ=5.16, the ridge regression model selected 5 parameters for VStore when predicting age (mean squared error 185.80, SE 19.34), and with λ=9.49 for Cogstate, the model selected all 8 tasks (mean squared error 226.80, SE 23.48). Finally, VStore was found to be highly sensitive (87%) and specific (91.7%) to age cohorts, with 94.6% of the area under the receiver operating characteristic curve.

Conclusions

Our findings suggest that VStore is a promising assessment that engages standard cognitive domains and is sensitive to age-related cognitive decline.
Transitioning From In-Person to Remote Clinical Research on Depression and Traumatic Brain Injury During the COVID-19 Pandemic: Study Modifications and Preliminary Feasibility From a Randomized Controlled Pilot Study
Authors: Fisher Lauren B , Tuchman Sylvie , Curreri Andrew J , Markgraf Maggie , Nyer Maren B , Cassano Paolo , Iverson Grant L , Fava Maurizio , Zafonte Ross D , Pedrelli Paola
Published: October 2021

Background

Telehealth has provided many researchers, especially those conducting psychosocial research, with the tools necessary to transition from in-person to remote clinical trials during the COVID-19 pandemic. A growing body of research supports the effectiveness of telemental health for a variety of psychiatric conditions, but few studies have examined telemental health for individuals with comorbid medical diagnoses. Furthermore, little is known about the remote implementation of clinical trials examining telemental health interventions.

Objective

This paper outlines the procedural modifications used to facilitate conversion of an in-person randomized controlled trial of cognitive behavioral therapy (CBT) for depression in individuals with traumatic brain injury (TBI; CBT-TBI) to a telemental health study administered remotely.

Methods

Given the nature of remote implementation and specific challenges experienced by individuals with TBI, considerations related to treatment delivery, remote consent, data management, neuropsychological assessment, safety monitoring, and delivery of supportive material have been discussed. Feasibility, acceptability, and safety were evaluated by examining attendance and participant responses on self-report measures of treatment satisfaction and suicidal behavior.

Results

High rates of treatment attendance, assessment completion, study retention, and satisfaction with the intervention and modality were reported by participants who completed at least one telemental health CBT-TBI session.

Conclusions

Study modifications are necessary when conducting a study remotely, and special attention should be paid to comorbidities and population-specific challenges (eg, cognitive impairment). Preliminary data support the feasibility, acceptability, and safety of remotely conducting a randomized controlled trial of CBT-TBI.

Trial Registration

ClinicalTrials.gov NCT03307070; https://clinicaltrials.gov/ct2/show/NCT03307070
An Intervention With Michigan-Grown Wheat in Healthy Adult Humans to Determine Effect on Gut Microbiota: Protocol for a Crossover Trial
Authors: Kinney Gigi A , Haddad Eliot N , Garrow Linda S , Ng Perry K W , Comstock Sarah S
Published: October 2021

Background

Daily fiber intake can increase the diversity of the human gut microbiota as well as the abundance of beneficial microbes and their metabolites. Whole-grain wheat is high in fiber.

Objective

This manuscript presents a study protocol designed to understand the effects of different types of wheat on gastrointestinal tract microbes.

Methods

Human adults will consume crackers made from three types of wheat flour (refined soft white wheat, whole-grain soft white wheat, and whole-grain soft red wheat). In this study, participants will alternate between crackers made from refined soft white wheat flour to those made from whole-grain soft white wheat and whole-grain soft red wheat flour. Survey and stool sample collection will occur after 7-day treatment periods. We will assess how wheat consumption affects gastrointestinal bacteria by sequencing the V4 region of 16S rRNA gene amplicons and the inflammatory state of participants’ intestines using enzyme-linked immunosorbent assays. The butyrate production capacity of the gut microbiota will be determined by targeted quantitative real-time polymerase chain reaction.

Results

We will report the treatment effects on alpha and beta diversity of the microbiota and taxa-specific differences. Microbiota results will be analyzed using the vegan package in R. Butyrate production capacity and biomarkers of intestinal inflammation will be analyzed using parametric statistical methods such as analysis of variance or linear regression. We expect whole wheat intake to increase butyrate production capacity, bacterial alpha diversity, and abundance of bacterial taxa responsive to phenolic compounds. Soft red wheat is also expected to decrease the concentration of inflammatory biomarkers in the stool of participants.

Conclusions

This protocol describes the methods to be used in a study on the impact of wheat types on the human gastrointestinal microbiota and biomarkers of intestinal inflammation. The analysis of intestinal responses to the consumption of two types of whole wheat will expand our understanding of how specific foods affect health-associated outcomes.

International Registered Report Identifier (IRRID)

DERR1-10.2196/29046