bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Gentrification Architecture Pursuit in Individuals with Childhood Left-behind Experiences—Empirical Analysis Based on the Perspective of Sports Participation
Authors: Hou Yuyang , Chen Sen , Yao Zhenning , Zhang Yujie , Huang Qian , Zhang Tianyi
Published: August 2024

Using a quantitative method, this paper examined the role of physical activity well-being before physical activity participation and gentrification architecture pursuit in 481 respondents (including 377 with childhood left-behind experiences) in Xi’an City, China, and tested the effect of the metacognition level of the group with childhood left-behind experiences on this pathway. The results showed that (1) physical activity participation of the group with childhood left-behind experiences had a significant positive predictive effect on gentrification architecture pursuit; (2) the level of physical activity participation of the group with childhood left-behind experiences could exert an indirect effect on gentrification architecture pursuit through physical activity well-being; (3) metacognition played a negative role in the pathway of physical activity participation predicting gentrification architecture pursuit of the group with childhood left-behind experiences; (4) the level of metacognition played a negative role in the pathway of physical activity participation and gentrification architecture pursuit of the group with childhood left-behind experiences; (5) metacognition also played a negative role in the path of physical activity well-being in predicting gentrification architecture pursuit in groups with childhood left-behind experiences. This paper is important in analyzing the complex effects of childhood left-behind experiences on individual consumption perceptions and develop a deeper understanding.
Current Research and Future Directions for Off-Site Construction through LangChain with a Large Language Model
Authors: Jeong Jaemin , Gil Daeyoung , Kim Daeho , Jeong Jaewook
Published: August 2024

Off-site construction is well-known technology that facilitates parallel processes of manufacturing and construction processes. This method enhances productivity while reducing accident, cost, and environmental impact. Many studies have highlighted its benefits, prompting further encouragement of off-site construction. This study consolidates current research and charts future directions by reviewing the existing literature. However, reviewing papers is time-intensive and laborious. Consequently, generative AI models, particularly Large Language Models (LLMs), are increasingly employed for document summarization. Specifically, LangChain influences LLMs through chaining data, demonstrating notable potential for research paper reviews. This study aims to evaluate the well-documented advantages of off-site construction through LangChain integrated with an LLM. It follows a streamlined process from the collection of research papers to conducting network analysis, examining 47 papers to uncover that current research primarily demonstrates off-site construction’s superiority through cutting-edge technologies. Yet, a data deficiency remains a challenge. The findings demonstrate that LangChain can rapidly and effectively summarize research, making it a valuable tool for literature reviews. This study advocates the broader application of LangChain in reviewing research papers, emphasizing its potential to streamline the literature review process and provide clear insights into off-site construction’s evolving landscape.
Assessing the Suitability of Phosphate Waste Rock as a Construction Aggregate
Authors: El Berdai Yahya , Trauchessec Romain , Taha Yassine , Safhi Amine el Mahdi , Hakkou Rachid , Benzaazoua Mostafa
Published: August 2024

Phosphate waste rock (PWR) is gaining attention as a potential alternative aggregate for concrete. Its valorization could reduce the environmental impacts of quarrying natural resources and stockpiling phosphate mining waste. This study comprehensively investigated the properties of fine and coarse aggregates produced from three rock types selected from PWR in Morocco: Flint, Phosflint, and Dolomite. A range of techniques was used to study their characteristics, including microstructural observations up to the microscale and X-ray computed tomography (X-CT), mineralogical and chemical compositions, physical and geotechnical properties such as Los Angeles (LA), micro-Deval (MDE), flexural strength, real dry density, and total porosity. The results showed that the coarse fractions of Flint, Phosflint, and Dolomite are code A or B of NF P 18-545 and exhibit good shape, density, and water absorption properties. Flint aggregates had the highest wear and fragmentation resistance with the lowest and finest porosity. They contained mainly quartz but also small proportions of Dolomite and fluorapatite. Phosflint aggregates had high resistance, shown by code A in LA and MDE values, and flexural strength equal to 17.1 MPa. They contained phosphate microfacies with a Ca/P atomic ratio equal to 1.8, cemented by cryptocrystalline silica. Dolomite aggregates’ mineralogical make-up consisted mainly of dolomite with the presence of quartz particles in addition to impurities. They also displayed significant total porosity (10–12%), as confirmed by X-CT. These findings were discussed to develop insights for the use of three types of PWR as alternative aggregates for concrete production. This investigation contributes to unveiling the properties of PWR as concrete aggregates and encourages circularity between the mining and construction sectors.
A Multi-Stage Method for Spatial Demands Prediction in Healthcare Buildings
Authors: Li Yongkui , Chi He , Zhang Yan , Song Ying
Published: August 2024

As urbanization accelerates and population structures change, healthcare buildings are becoming increasingly crowded. Predicting functional area demand is crucial to adapting to this trend and providing high-quality services. This paper introduces an innovative multi-stage method to forecast unbuilt projects using operational data from hospital information systems and building design models to automatically calculate spatial demands. The study’s main findings demonstrate that our method successfully outputs regional demand data, supporting hospital design validation and operational decision-making. Through processing and analyzing log data, this research identified the dynamic characteristics of user activities in hospital buildings and converted them into a time series data format. This method has iterative self-validation and self-optimization features and can maintain flexibility in different scenarios and frequently changing design drawings. This method will provide technical support for a wide range of hospital building stakeholders and has the potential to be applied to more types of buildings. These findings will contribute to various fields, including medical facility planning, design, and public health.
Somatic Mutation Profile as a Predictor of Treatment Response and Survival in Unresectable Pancreatic Ductal Adenocarcinoma Treated with FOLFIRINOX and Gemcitabine Nab-Paclitaxel
Authors: Paredes de la Fuente Rodrigo , Sucre Santiago , Ponce Cristina , Rattani Ahmed Anwer Ali , Peters Mary Linton B.
Published: August 2024

(1) Background: Pancreatic ductal adenocarcinoma (PDAC) has low survival rates despite treatment advancements. Aim: This study aims to show how molecular profiling could possibly guide personalized treatment strategies, which may help improve survival outcomes in patients with PDAC. (2) Materials and Methods: A retrospective analysis of 142 PDAC patients from a single academic center was conducted. Patients underwent chemotherapy and next-generation sequencing for molecular profiling. Key oncogenic pathways were identified using the Reactome pathway database. Survival analysis was performed using Kaplan–Meier curves and Cox Proportional Hazards Regression. (3) Results: Patients mainly received FOLFIRINOX (n = 62) or gemcitabine nab-paclitaxel (n = 62) as initial chemotherapy. The median OS was 13.6 months. Longer median OS was noted in patients with NOTCH (15 vs. 12.3 months, p = 0.007) and KIT pathway mutations (21.3 vs. 12.12 months, p = 0.04). Combinatorial pathway analysis indicated potential synergistic effects on survival. In the PFS, PI3K pathway (6.6 vs. 5.7 months, p = 0.03) and KIT pathway (10.3 vs. 6.2 months, p = 0.03) mutations correlated with improved PFS within the gemcitabine nab-paclitaxel subgroup. (4) Conclusions: Molecular profiling could play a role in PDAC for predicting outcomes and responses to therapies like FOLFIRINOX and gemcitabine nab-paclitaxel. Integrating genomic data into clinical decision-making can benefit PDAC treatment, though further validation is needed to fully utilize precision oncology in PDAC management.
High-Dose-Rate Brachytherapy for Treatment of Facial Skin Cancers: Local Control, Toxicity, and Quality of Life in 67 Patients
Authors: Monge-Cadet Jeanne , Vairel Benjamin , Morisseau Mathilde , Moyal Elizabeth , Ducassou Anne , Chira Ciprian , Pagès Cécile , Sibaud Vincent , Brun Thomas , Modesto Anouchka
Published: August 2024

While treatment of localized cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) is based on surgery, brachytherapy, which delivers a high dose of radiation to tumor tissue while sparing healthy tissue, is an alternative. Since the withdrawal of iridium wires from the market, brachytherapy has mainly been performed with high-dose-rate iridium-192 (HDR). This study evaluated the efficacy of HDR brachytherapy in terms of local control, survival, toxicity, and quality of life in patients with facial periorificial cutaneous SCC or BCC treated in our center between 2015 and 2021. Sixty-seven patients were treated for SCC (n = 49) or BCC (n = 18), on the nose (n = 29), lip (n = 28), eyelid (n = 7), or ear (n = 3). The majority had Tis or T1 tumors (73.1%). After a median follow-up of 28 months, 8 patients had a local recurrence. The local control rate at 3 years was 87.05% (95% CI 74.6–93.7). All patients developed grade 1–2 acute radio-mucositis or radiodermatitis and one experienced reversible grade 3 acute radio-mucositis. Of the 27 patients who completed the quality-of-life questionnaire, 77.8% recommended the treatment. This study confirms that HDR brachytherapy for facial cutaneous carcinomas provides good local control, good tolerance, and satisfactory functional outcome.
Editorial: A Special Issue on “Catalytic Processes in Biofuel Production and Biomass Valorization, 2nd Edition”
Authors: Carlucci Claudia
Published: August 2024

The depletion of fossil fuels, attributable to the rapid increase in the world’s population and the growth of industrialization, is estimated to run out in less than ten decades if not replaced by alternative energy sources [...]
Sequence of Molecular Events in the Development of Alzheimer’s Disease: Cascade Interactions from Beta-Amyloid to Other Involved Proteins
Authors: Bagheri Soghra , Saboury Ali Akbar , Saso Luciano
Published: August 2024

Alzheimer’s disease is the primary neurodegenerative disease affecting the elderly population. Despite the first description of its pathology over a century ago, its precise cause and molecular mechanism remain unknown. Numerous factors, including beta-amyloid, tau protein, the APOEε4 gene, and different metals, have been extensively investigated in relation to this disease. However, none of them have been proven to have a decisive causal relationship. Furthermore, no single theory has successfully integrated these puzzle pieces thus far. In this review article, we propose the most probable molecular mechanism for AD, which clearly shows the relationship between the main aspects of the disease, and addresses fundamental questions such as: Why is aging the major risk factor for the disease? Are amyloid plaques and tau tangles the causes or consequences of AD? Why are the distributions of senile plaques and tau tangles in the brain different and independent of each other? Why is the APOEε4 gene a risk factor for AD? Finally, why is the disease more prevalent in women?
Effects of Angiogenic Factors on the Epithelial-to-Mesenchymal Transition and Their Impact on the Onset and Progression of Oral Squamous Cell Carcinoma: An Overview
Authors: Pomella Silvia , Melaiu Ombretta , Dri Maria , Martelli Mirko , Gargari Marco , Barillari Giovanni
Published: August 2024

High levels of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)-2 and angiopoietin (ANG)-2 are found in tissues from oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). As might be expected, VEGF, FGF-2, and ANG-2 overexpression parallels the development of new blood and lymphatic vessels that nourish the growing OPMDs or OSCCs and provide the latter with metastatic routes. Notably, VEGF, FGF-2, and ANG-2 are also linked to the epithelial-to-mesenchymal transition (EMT), a trans-differentiation process that respectively promotes or exasperates the invasiveness of normal and neoplastic oral epithelial cells. Here, we have summarized published work regarding the impact that the interplay among VEGF, FGF-2, ANG-2, vessel generation, and EMT has on oral carcinogenesis. Results from the reviewed studies indicate that VEGF, FGF-2, and ANG-2 spark either protein kinase B (AKT) or mitogen-activated protein kinases (MAPK), two signaling pathways that can promote both EMT and new vessels’ formation in OPMDs and OSCCs. Since EMT and vessel generation are key to the onset and progression of OSCC, as well as to its radio- and chemo-resistance, these data encourage including AKT or MAPK inhibitors and/or antiangiogenic drugs in the treatment of this malignancy.
Neonicotinoid Pesticides Affect Developing Neurons in Experimental Mouse Models and in Human Induced Pluripotent Stem Cell (iPSC)-Derived Neural Cultures and Organoids
Authors: Mariani Alessandro , Comolli Davide , Fanelli Roberto , Forloni Gianluigi , De Paola Massimiliano
Published: August 2024

Neonicotinoids are synthetic, nicotine-derived insecticides used worldwide to protect crops and domestic animals from pest insects. The reported evidence shows that they are also able to interact with mammalian nicotine receptors (nAChRs), triggering detrimental responses in cultured neurons. Exposure to high neonicotinoid levels during the fetal period induces neurotoxicity in animal models. Considering the persistent exposure to these insecticides and the key role of nAChRs in brain development, their potential neurotoxicity on mammal central nervous system (CNS) needs further investigations. We studied here the neurodevelopmental effects of different generations of neonicotinoids on CNS cells in mouse fetal brain and primary cultures and in neuronal cells and organoids obtained from human induced pluripotent stem cells (iPSC). Neonicotinoids significantly affect neuron viability, with imidacloprid (IMI) inducing relevant alterations in synaptic protein expression, neurofilament structures, and microglia activation in vitro, and in the brain of prenatally exposed mouse fetuses. IMI induces neurotoxic effects also on developing human iPSC-derived neurons and cortical organoids. Collectively, the current findings show that neonicotinoids might induce impairment during neuro/immune-development in mouse and human CNS cells and provide new insights in the characterization of risk for the exposure to this class of pesticides.
PPAR-Mediated Bile Acid Glucuronidation: Therapeutic Targets for the Treatment of Cholestatic Liver Diseases
Authors: Gallucci Gina M. , Hayes Colleen M. , Boyer James L. , Barbier Olivier , Assis David N. , Ghonem Nisanne S.
Published: August 2024

Cholestatic liver diseases, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), result from an impairment of bile flow that leads to the hepatic retention of bile acids, causing liver injury. Until recently, the only approved treatments for PBC were ursodeoxycholic acid (UDCA) and obeticholic acid (OCA). While these therapies slow the progression of PBC in the early stage of the disease, approximately 40% of patients respond incompletely to UDCA, and advanced cases do not respond. UDCA does not improve survival in patients with PSC, and patients often have dose-limiting pruritus reactions to OCA. Left untreated, these diseases can progress to fibrosis and cirrhosis, resulting in liver failure and the need for transplantation. These shortcomings emphasize the urgent need for alternative treatment strategies. Recently, nuclear hormone receptors have been explored as pharmacological targets for adjunct therapy because they regulate enzymes involved in bile acid metabolism and detoxification. In particular, the peroxisome proliferator-activated receptor (PPAR) has emerged as a therapeutic target for patients with PBC or PSC who experience an incomplete response to UDCA. PPARα is predominantly expressed in the liver, and it plays an essential role in the regulation of cytochrome P450 (CYP) and uridine 5’-diphospho-glucuronosyltransferase (UGT) enzymes, both of which are critical enzyme families involved in the regulation of bile acid metabolism and glucuronidation, respectively. Importantly, PPARα agonists, e.g., fenofibrate, have shown therapeutic benefits in reducing elevated markers of cholestasis in patients with PBC and PSC, and elafibranor, the first PPAR (dual α, β/δ) agonist, has been FDA-approved for the second-line treatment of PBC. Additionally, newer PPAR agonists that target various PPAR isoforms (β/δ, γ) are under development as an adjunct therapy for PBC or PSC, although their impact on glucuronidation pathways are less characterized. This review will focus on PPAR-mediated bile acid glucuronidation as a therapeutic pathway to improve outcomes for patients with PBC and PSC.
Energy Storage Performance of Na0.5Bi0.5TiO3–CaHfO3 Lead-Free Ceramics Regulated by Defect Engineering
Authors: Li Zhuo , Zhang Jing , Wang Zixuan , Wei Xiaotian , Long Dingjie , Zhao Xin , Niu Yanhui
Published: August 2024

Over the past decades, Na0.5Bi0.5TiO3 (NBT)-based ceramics have received increasing attention in energy storage applications due to their high power density and relatively large maximum polarization. However, their high remnant polarization (Pr) and low breakdown field strength are detrimental for their practical applications. In this paper, a new solid solution (1−x)Na0.5Bi0.5TiO3–xCaHfO3 (x = 0.04, 0.08, 0.12, 0.16) was constructed by introducing CaHfO3 into NBT, and thus was prepared using a conventional solid-state reaction. With the addition of CaHfO3, the disorder of the structure increased, A-site vacancies formed, and thus oxygen vacancies were suppressed due to the replacement of the Na+ by Ca2+, resulting in the enhanced relaxation behavior and the reduced Pr, the refined grain, and improved breakdown strength. Furthermore, an optimal recoverable energy storage density (Wrec) of 1.2 J/cm3 was achieved in 0.92Na0.5Bi0.5TiO3–0.08CaHfO3 ceramics under the breakdown strength of 140 kV/cm, which is mainly attributed to the resultant defect of Na+ vacancy.
Synthesis of Bulk-Nucleated Glass–Ceramics and Porous Glass–Ceramic Composites through Utilization of Fly Ashes
Authors: Fernandes Hugo R. , Gunduz Oguzhan , Tulyaganov Dilshat U.
Published: August 2024

Coal combustion in power plants for electric power generation produces millions of tons of residues that are generally disposed of in landfills or ponds occupying vast land, resulting in serious environmental pollution. Fly ash (FA) is one of the main solid wastes generated in coal-based thermal power plants, representing the largest fraction of coal combustion residues (65–95%). Unfortunately, the enormous amount of FA residue is utilized only partly, mainly in the cement industry and building materials field. An alternative approach to using FA is its incorporation into ceramic, glass and glass–ceramic production, aligning with circular economy principles and reducing the environmental footprint of both the energy and ceramic sectors. In this review article, the topics of the composition, properties, classification, and utilization of fly ashes from thermal power plants are discussed. The main objective of this work is a critical analysis of the experimental trials directed to the involvement of FA as a raw material in the fabrication of glass–ceramics and porous ceramic composites.
Crystal Structures, Magnetic Properties, and Redox Behaviors of Carboxylato-Bridged Mn(II) Complexes with Ditopic Ligands Featuring N3-Coordination Sites
Authors: Sugiyama Junya , Umemoto Yusuke , Sato Sota , Yoneda Ko , Koikawa Masayuki
Published: August 2024

Carboxylato-bridged dinuclear and tetranuclear Mn(II) complexes 1–3 with ditopic ligands featuring two N3-terminal coordination sites connected by hexyl (tphn), octyl (tpon), and p-xylyl (tpxn) linkers have been synthesized and characterized through X-ray single-crystal structure analyses, infrared spectroscopy, and elemental analyses. Complex 1 is a μ-fluorido-bis-μ-acetato dinuclear Mn(II) complex where the ligand tphn coordinates to both terminal sides of a dinuclear Mn unit. In contrast, complexes 2 and 3 are tetranuclear Mn(II) complexes with a macrocyclic structure, in which two dinuclear Mn units are linked by ligands tpon or tpxn. The redox behaviors of 1 and 2 were elucidated by cyclic voltammetry, revealing two metal-centered redox processes corresponding to Mn2(II,II)/Mn2(II,III) and Mn2(II,III)/Mn2(III,III).
Experimental and Theoretical Studies on DNA Binding and Anticancer Activity of Nickel(II) and Zinc(II) Complexes with N– (8–Quinolyl) Salicylaldimine Schiff Base Ligands
Authors: Pinchaipat Bussaba , Chotima Ratanon , Promkatkaew Malinee , Kitjaruwankul Sunan , Chainok Kittipong , Khudkham Teerawat
Published: August 2024

Transition metal complexes of nickel(II) with 5–bromo–N–(8–quinolyl)salicylaldimine (HqsalBr, HL1); [Ni(qsalBr)2] (1) and 3,5–dibromo–N–(8–quinolyl)salicylaldimine (HqsalBr2, HL2); [Ni(qsalBr2)2] (3) including zinc(II) complex with HL1, [Zn(qsalBr)2] (2), have been synthesized and successfully characterized using various techniques, namely IR, NMR, mass spectrometry, thermogravimetric analysis (TGA), and single crystal X–ray crystallography. DFT calculations were employed to examine the structural and electronic parameters of the complexes at their optimized geometries. The complexes showed strong DNA-binding activities, assessed by UV-Vis and fluorescence spectroscopy, primarily through intercalation. Molecular docking investigations were carried out to provide profound insights into the interaction mechanisms of these complexes with DNA and lung cancer cells. These computational studies revealed that [Ni(qsalBr2)2] (3) exhibits the most favorable negative binding energies, −9.1 kcal/mol with DNA and −9.3 kcal/mol with cancer cells, facilitated by hydrogen bonding and hydrophobic interactions. Furthermore, the in vitro anticancer activity was evaluated against the A549 human lung adenocarcinoma cell line, with [Zn(qsalBr)2] (2) exhibiting the highest potency against this cancer cell line.
Differences in the Development of Motor Skills in Portuguese Children Aged 12 Months after 3 Years of COVID-19 Confinement
Authors: Rebelo Miguel , Paulo Rui , Honório Samuel , Petrica João , Batista Marco , Duarte-Mendes Pedro , Marques Catarina , Serrano João
Published: August 2024

(1) Background: The objective of the study was to verify the effects of COVID-19 confinement on motor skills through a longitudinal study in Portuguese children who were one year old at the beginning of the pandemic. (2) Methods: The sample consisted of 88 children of both sexes, in the pre-COVID-19 assessment, they were 13.31 ± 2.4 months old and in the post-COVID-19 assessment, the same children were already 49.31 ± 2.5 months old. Motor skills were assessed using the PDMS-2 scales. For the statistical analysis, the Kolmogorov–Smirnov test was used to test normality, and the Wilcoxon test was used to compare the results of the two assessments in the same sample. (3) Results: There were statistically significant differences in all motor skills assessed, with children presenting, on average, worse results in all global motor skills in the post-COVID-19 assessment, as opposed to fine motor skills, showing better results in the post-COVID-19 assessment. (4) Conclusions: These results show the negative impact of the pandemic on children evaluated with a special emphasis on global motor skills, with the majority demonstrating values considered below average for their age, noting that the pandemic protocols may have had serious consequences on children’s motor development, warning professionals who deal daily with children in these age groups about the importance of stimulating global motor skills.
Fear of Fat, Processes of Change, and Weight-Related Behaviors in Mexican and Spanish Adolescents
Authors: Marentes-Castillo María , Castillo Isabel , Tomás Inés , González-Acevedo Olivia , Álvarez Octavio
Published: August 2024

Background: Fear of fat is a relevant variable in initiating weight regulation behaviors in adolescents. However, little is known about the experiential and behavioral change processes that mediate the choice between healthy and unhealthy weight regulation behaviors in this population. Method: The general objective was to examine the predictive role of fear of fat on weight-related behaviors (healthy and unhealthy weight control behaviors) through the mediation of experiential and behavioral change processes (consciousness raising, counterconditioning, helping relationships, reinforcement management, self-liberation, self-reevaluation, stimulus control, substance use) in 838 adolescents aged 15–19 years from Mexico and Spain using parallel mediation analysis. Additionally, the study examined the correlations between the variables with regard to gender and country, as well as the differences in the use of processes of change across stages of change through the use of a multivariate analysis of variance. The Spanish version of the Fear of Fat, Stages of Change, Processes of Change, and Weight-Related Behaviors scales were used. Results: The mediation analysis showed that fear of fat predicted healthy weight control behaviors through consciousness raising, self-liberation, and stimulus control. On the other hand, fear of fat predicted unhealthy weight control behaviors through counterconditioning, stimulus control, and the use of weight loss substances. Intervening to reduce fear of fat may be a way to modify the processes of change used by adolescents to regulate their weight. Conclusions: The results of this study indicate that adolescents may initiate weight control behaviors as a result of fear of fat. This process is mediated by experiential and behavioral processes that influence weight regulation.
Evaluation of Family-Based Interventions as a Therapeutic Tool in the Modulation of Childhood Obesity: A Systematic Review
Authors: Fernández-Lázaro Diego , Celorrio San Miguel Ana M. , Garrosa Evelina , Fernández-Araque Ana M. , Mielgo-Ayuso Juan , Roche Enrique , Arribalzaga Soledad
Published: August 2024

Childhood obesity is a major public health burden. The prevalence of weight excess for children and the adolescent population (8 to 16 years) is 34.9%. During childhood, lifestyles are acquired, which are developed in adulthood. In this context, the role of parents is crucial, since they are the model to imitate. We aimed to evaluate the current evidence on the effects of family-based interventions as a tool in the treatment of childhood obesity. We reviewed studies indexed in several databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Original articles published from 1 January 2014 to 30 May 2024 with a controlled trial design were considered, in which family-based interventions were carried out compared to a control group or to data before the intervention. Although 148 records were identified in the search, 6 studies met inclusion criteria. Overall, studies reported beneficial effects of family-based interventions on improving anthropometric parameters: BMI z-score, BMI, waist circumference, and body fat percentage. Regarding nutritional and physical activity guidelines, general recommendations must consider increased consumption of fruits and vegetables, reducing sugary drinks, controlled screen time, and 30–60 min of physical activity/day. Thus, family-based interventions could be an effective non-pharmacological strategy for modulating childhood obesity, allowing families to modify their lifestyles.
The Second Variation of the Potential Energy and the Theory of Elastic Stability
Authors: Como Mario
Published: August 2024

We remember and comment on the research scenario of the theory of elastic stability that accompanied all the course of studies, carried out with enthusiasm and passion, of Prof. Marcello Pignataro, who we still miss and to whom our affectionate memory goes. Marcello was in continuous contact with Professor Koiter in Delft, to study, with a new approach, the many and still open problems of the nonlinear theory of elastic stability. In those times, the entire approach used in the study of the equilibrium stability of elastic structures was in question and its basis seemed to need to be reformulated. The central theme was the definition of the stability criterion of the second variation of the potential energy and how it being definite positive could effectively imply stability.
NO2 Adsorption on Biochar Derived from Wood Shaving Litter: Understanding Surface Chemistry and Adsorption Mechanisms
Authors: Zbair Mohamed , Drané Méghane , Limousy Lionel
Published: August 2024

This study investigates the production of biochar from fresh wood shavings (B-WSF) and used wood shavings (B-WSU–animal litter) biomass through pyrolysis at 450 °C and explores its potential for NO2 adsorption at different temperatures from 22 °C to 250 °C. The biochars’ thermal stability, elemental composition, mineral content, textural properties, and surface chemistry were comprehensively analyzed using various techniques, including thermogravimetric analysis (TGA), ultimate analysis, proximate analysis, mineral composition analysis, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and NO2 adsorption experiments. The results indicate that biochars derived from WSF and WSU biomass possess high stability and exhibit significant changes in their elemental composition, surface functional groups, and textural properties compared to the raw biomass. The biochars demonstrated substantial NO2 adsorption capacities and reduction, with B-WSU biochar exhibiting higher adsorption capacity attributed to its higher specific surface area, mineral content, and functional groups. In addition, the results reveal distinct patterns in NO2 adsorption and NO release, with temperature playing a pivotal role in the process. At lower temperatures, NO2 adsorption on both biochars exhibits gradual increases, while higher temperatures facilitate immediate adsorption and subsequent reduction to NO. The adsorption of NO2 increased with increasing adsorption temperature, with B-WSU biochar achieving a maximum adsorption capacity of 43.54 mg/g at 250 °C, compared to 9.62 mg/g for B-WSF biochar. Moreover, XPS analysis revealed alterations in surface functional groups upon NO2 exposure, indicating enhanced surface oxidation and formation of nitrogen-containing species. In addition, differences in surface heterogeneity and mineral content influence NO2 adsorption behavior between the biochar samples. These findings highlight the potential of WSF biomass-derived biochar as an effective adsorbent for NO2 removal, offering insights into its application in air pollution mitigation strategies. The mechanism of NO2 adsorption involves chemisorption on oxygen-containing functional groups and physical adsorption, facilitated by the high specific surface area and pore volume of the biochar. Furthermore, the rich mineral content in B-WSU biochar explains its high adsorption capacity, demonstrating the potential for valorization of waste materials in the circular economy.
Safety Footwear Impact on Workers’ Gait and Foot Problems: A Comparative Study
Authors: Arceri Alberto , Mazzotti Antonio , Liosi Sofia Gaia , Zielli Simone Ottavio , Artioli Elena , Langone Laura , Traina Francesco , Brognara Lorenzo , Faldini Cesare
Published: August 2024

Background: In this study, we hypothesized that safety footwear (SF) impacts gait patterns, potentially contributing to the podiatric symptoms reported by workers. The purpose of this work was to compare the gait analyses of workers wearing SF and sneakers using inertial sensors while also examining the occurrence of foot problems. Methods: A consecutive cohort of workers from different occupational sectors who wore SF during their work shifts were prospectively assessed through a gait analysis. The gait analysis was conducted under two conditions: first, while wearing SF, and second, while wearing sneakers. In both conditions, inertial sensors were used (Wiva® MOB). Participants also underwent a podiatric physical examination to evaluate foot problems. Results: This study shows that SF resulted in a worsening gait pattern compared to sneakers in both genders. The impact was particularly pronounced in female participants, resulting in a significant decline in walking speed and cadence. Discomfort was reported by 83.3% of participants, with a higher prevalence in females (46.6% vs. 36.6%). The SF group exhibited an elevated prevalence of foot problems, with no significant gender variations. It seems that foot problems are more likely to occur when a foot deformity, such as flat or cavus foot or hallux valgus, is present. Conclusions: This study suggests that SF may contribute to the reported podiatric symptoms among workers. Certain footwear characteristics, including weight, mis-fit, and inadequate design, may be factors associated with footwear discomfort and adverse gait patterns, potentially leading to increased foot problems among workers.
Leveraging Generative Artificial Intelligence Models in Patient Education on Inferior Vena Cava Filters
Authors: Singh Som P. , Jamal Aleena , Qureshi Farah , Zaidi Rohma , Qureshi Fawad
Published: August 2024

Background: Inferior Vena Cava (IVC) filters have become an advantageous treatment modality for patients with venous thromboembolism. As the use of these filters continues to grow, it is imperative for providers to appropriately educate patients in a comprehensive yet understandable manner. Likewise, generative artificial intelligence models are a growing tool in patient education, but there is little understanding of the readability of these tools on IVC filters. Methods: This study aimed to determine the Flesch Reading Ease (FRE), Flesch–Kincaid, and Gunning Fog readability of IVC Filter patient educational materials generated by these artificial intelligence models. Results: The ChatGPT cohort had the highest mean Gunning Fog score at 17.76 ± 1.62 and the lowest at 11.58 ± 1.55 among the Copilot cohort. The difference between groups for Flesch Reading Ease scores (p = 8.70408 × 10−8) was found to be statistically significant albeit with priori power found to be low at 0.392. Conclusions: The results of this study indicate that the answers generated by the Microsoft Copilot cohort offers a greater degree of readability compared to ChatGPT cohort regarding IVC filters. Nevertheless, the mean Flesch–Kincaid readability for both cohorts does not meet the recommended U.S. grade reading levels.
Quality Changes in Fresh-Cut Lettuce When Subjected to Ultrasound Combined with Zinc Oxide Nanoparticle (ZnO NP) Treatment
Authors: Xu Xianmeng , Dong Yulu , Xu Weiwen , Wang Shunmin , Zhu Jiahui , Xu Yudie , Xu Min
Published: August 2024

The effects of three preservation methods (ultrasound, ZnO NPs, and ultrasound combined with ZnO NPs) on the odor, microstructure, and edible quality of fresh-cut lettuce were investigated in this study. When stored for 8 days, significant improvements were observed in the following when using ultrasound combined with ZnO NP treatment to better preserve fresh-cut lettuce (and were reduced when compared with the control group): the color (L* value (34.53); a* value (−5.89); b* value (15.00); browning index (40.63); firmness (25.66); propectin (2.12%); chlorophyll (2.75 mg/100 g); cellulose (20.35%); total phenolic content (0.95 mg/100 g); PAL activity (54.91 U·h−1·g−1); CAT activity (41.78 U·min−1·mg−1); ABTS free-radical scavenging ability (137.62 µmol/L); FRAP total reducing ability (94.42 µmol/L) (p < 0.05), PPO activity (0.85 U·min−1·g−1); MDA (1.97 µmol/g); and H2O2 (54.26 µmol/g). In addition, the results of the volatile components indicated that the use of ultrasound combined with ZnO NP treatment decreased the production of adverse flavor compounds by inhibiting the generation of aldehydes and ketones, as well as by promoting the generation of olefins, nitriles, and quinolines, and the contents of nitriles and quinolines were 20.07% and 2.07% of the total components, respectively. The resultant microstructure indicated that the microchannels generated by ultrasound allowed for the ZnO NPs to enter the intracellular cavity of the fresh-cut lettuce more efficiently; such a finding could serve as a basis for a hypothesis on the mechanism of ultrasound combined with ZnO NP treatment. The results of fresh-cut lettuce preservation when using ultrasound combined with ZnO NPs were better than those that were obtained when using ultrasound and ZnO NP treatment alone. And, using ultrasound combined with ZnO NP treatment as a new preservation method for fresh-cut lettuce provides a promising preservation idea for other fresh-cut fruits and vegetables.
Study of the Impact of Surface Topography on Selected Mechanical Properties of Adhesive Joints
Authors: Sługocka Małgorzata , Grochała Daniel , Kwiatkowski Konrad , Grzejda Rafał , Zmarzły Paweł
Published: August 2024

Manufacturers of adhesives for industrial use determine the strength of adhesive joints during shear tests. Most often, components made of the same material are joined. In contrast, the roughness of the surfaces to be joined results from the use of a specific surface treatment technology. In adhesive manufacturers’ recommendations for metal-to-metal joints, surface technologies can be found without specifying numerical requirements for roughness. Modern techniques for shaping the geometric accuracy of components allow the formation of determined irregularities on the surface, which are characterised by their height and mutual distribution. Furthermore, regular irregularities can be obtained by using the appropriate tool and technological machining parameters. In this way, surfaces with similar load-bearing capacity, core volume, texture or expected hydrophobic properties can be produced by various methods. However, a basic prerequisite is the careful definition of the numerical requirements, both for the basic roughness indices and those of a complementary nature. As a rule, the strength of the adhesive joint is also lower than the strength of the adhesive itself. The strength of an adhesive joint depends on the ‘mechanical anchorage’ of the adhesive and the adhesion phenomenon on the surface. The research assumes that it is possible to induce an interaction between the geometric state of the surface and the properties of the adhesive, so as to guarantee the maximum strength of the adhesive joint. To verify this, a series of experimental tests were developed and carried out for two different adhesives characterised by different viscosities and offered bond strength. Based on the tests carried out, recommendations were made to the designers of adhesive joints, where, in addition to the height of the surface irregularities, the properties related to fluid retention and the shape of the irregularities in the valleys should be determined.
Aging Behaviors of Organic Electrophoretic Coating on Magnesium Alloy
Authors: Wang Xiaoxue , Wang Guohui , Jing Yuan , Zheng Kai , Wang Rongqiao , Liu Xiuchun , Gao Kai , Sun Jingli , Yuan Yong , Meng Fandi
Published: August 2024

VW63Z magnesium alloy, known for its high strength-to-weight ratio and excellent mechanical properties, is a promising candidate for applications in the automotive industries. Among the anti-corrosion technologies for VW63Z alloys, organic electrophoretic coatings have gained significant attention due to their ability to provide a uniform and controlled coating thickness, high coating adhesion, and excellent corrosion protection properties. In this work, to investigate the aging behaviors of an organic electrophoretic coating for magnesium alloys, water absorption kinetics curves of the coatings after immersion in 3.5 wt.% NaCl at 20 °C and 40 °C were measured, and parameters such as the saturated water absorption and saturation time of the free film coatings were fitted to determine the densification evolution of the organic coatings. A tensile test was used to test the tensile strength of the organic coating during service to determine the evolution of the strength and toughness of the organic coating. The evolution of wet adhesion of organic coatings with service time was tested by ASTM D4541-02. The impedance spectra of the organic coatings under the above conditions were detected by EIS, and finally, the failure behavior of the organic coatings under immersion was analyzed.
Surface Modification of AM60 Mg-Al Alloy with Vanadium and V2O5 Sputtered Deposits: Activity in Marine Ambience
Authors: Sánchez Gerardo , Veleva Lucien , Flores Eduardo
Published: August 2024

Vanadium (~450 nm) and V2O5 (~350 nm) were deposited by DC magnetron sputtering on an AM60 substrate to improve its degradation resistance in marine ambience. According to Raman and XPS analysis, the vanadium nanofilm mainly consists of amorphous V2O3, while V2O5 comprises two sheets of VO5 and VO4 units. After 30 days of immersion of the coated AM60 in a marine model solution (SME), the shift of the pH of the SME to more alkaline values was less pronounced for V2O5-AM60 because of the HCl acid formation during the partial dissolution of V2O5 in the presence of NaCl, and thus, a higher concentration of Mg2+ ions ~100 mg L-1 was released from the Mg (AM60) matrix. The lower concentration of ~40 mg L-1 from the V-AM60 surface was attributed to the possible intercalation of the released Mg ions (cations) into the conductive tunnels of V2O3 as the main component of the vanadium sputtered deposit. This oxide has been reported as a material for high-capacitive energy storage. In this way, the V-deposit provided longer partial protection for the AM60 surface (Mg matrix) from localized pitting attacks.
Creating Diverse Patterns on Thin Polystyrene Film through Water-in-Oil Emulsion Coating and Utilizing the Derived Hydrophilic Holes as a Microreactor
Authors: Hauan Zin Thwe , Hong Liang
Published: August 2024

The study investigates the surface morphology of polystyrene (PS) thin films, which were crafted by drying a cast emulsion layer on a microscope glass slide. A water-in-oil (w/o) emulsion was previously formulated by dispersing a small quantity of water (or an aqueous solution) into a chloroform–PS solution containing a dissolved emulsifier (surfactant). The resultant emulsion was spin-coated onto the glass slide. Subsequently, the type and dosage of surfactant utilized played a critical role in incubating the pattern formation during solvent evaporation. Mechanistically, the surface patterns resulted from a collaborative interplay of drying-induced droplet migration/partial coagulation and surface enrichment of surfactants. Span-80 induces a collection of bowl-shaped holes with a diameter of approximately 1 µm, while AOT induces an M-shaped geometrical pattern. The holes on PS film act as a microreactor to carry out the crystallization of acrylamide, as well as the growth of Ni-P alloy dendrites by electroless plating means. Alternatively, the dispersed aqueous droplet of the emulsion was utilized to conduct in situ reduction to grow copper nanoparticles. It is also noteworthy that the patterned PS films achieved exhibit diverse glass transition behaviors, attributed to the unique interaction of surfactant and PS chains.
Prioritising Ex Situ Conservation for Malagasy Mammal Species in Line with IUCN’s ‘One Plan Approach to Conservation’
Authors: Rose Anna , Tuchtfeldt Marie , Lammers Robin , Rode-White Johanna , Markolf Matthias , Pagel Theo , Rödder Dennis , Ziegler Thomas
Published: August 2024

Madagascar, as one of the global biodiversity hotspots, hosts numerous unique terrestrial mammal species that need urgent protection. To identify priority species for conservation, an updated list of terrestrial Malagasy mammal species was compiled, including their threat status, distribution, endemism level, Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) listing, and Evolutionarily Distinct and Globally Endangered (EDGE) score. An overview of these species kept in zoos worldwide was created using the Zoological Information Management System and Zootierliste to assess ex situ conservation efforts. Nearly 60% of the 212 native terrestrial mammal species are threatened with extinction, with 18% being regional endemics, 39% microendemics, and 42% endemics. The majority of these species (92%) occur within protected areas. About half of Madagascar’s mammals are listed under CITES, and less than half have an EDGE score. Only 34 species are kept in zoos globally, with 26 Red-Listed as threatened. Nine out of seventeen families are not represented in zoos. A total of 1545 institutions, primarily in Europe and North America, keep Malagasy mammal species, with successful reproduction reported for 28 species in the last 12 months, 23 of them listed as threatened on the IUCN Red List. To maximize conservation, we recommend reallocating resources towards priority species and implementing concerted ex situ and in situ actions as proposed by the IUCN’s One Plan Approach.
Wood Mice Utilize Understory Vegetation of Leafless Dead Dwarf Bamboo Culms as a Habitat and Foraging Site
Authors: Kajita Rui , Kajimura Hisashi
Published: August 2024

In this study, we conducted a field survey in Aichi Prefecture, central Japan, to clarify whether rodent activity is affected by the presence or absence of dead culms of the dwarf bamboo Sasa borealis, a species characterized by a 120-year cycle of large-scale flowering, seeding, and dying. We found that a relatively larger number of wood mice, Apodemus speciosus and Apodemus argenteus, were caught using Sherman live traps in areas with dead S. borealis culms than in areas lacking the culms, thereby indicating that S. borealis culms, even if dead and leafless, can function as shelters in which the mice can evade predation. However, in the years when A. speciosus was abundant, A. argenteus avoided areas inhabited by A. speciosus and was restricted to areas lacking dead culms, which were devoid of shelter. A feeding experiment using Castanea crenata acorns clearly revealed that a larger number of acorns were foraged by mice in areas containing dead culms. Moreover, in the area with dead culms, the mice preferentially removed sound acorns prior to taking acorns that had been vacated by infesting moth larvae. These findings indicate that the shelter function of dead culms enables mice to carefully select sound acorns, which are nutritionally more beneficial than those that have been infested by moth larvae.