bluuebunny/crossref_metadata_2025 huggingface dataset:
Negros, LGBTI e periféricos: o impacto das relações entre movimentos na consolidação de ativismos interseccionais
Authors: Zanoli Vinícius
Published: September 2021

Neste artigo, baseado em investigação etnográfica realizada entre 2015 e 2019, discuto os impactos das relações entre movimentos sociais na consolidação de um ativismo interseccional. Trata-se de uma análise das redes nas quais atua o Aos Brados, um coletivo LGBTI, negro e da periferia fundado há mais de 20 anos em Campinas (São Paulo, Brasil). Aqui, demonstro como o grupo, ao circular por uma teia que conecta atores e movimentos distintos, passa a aderir e ressignificar noções e práticas políticas que circulam em tal rede. Ao analisar as atividades culturais que passaram a realizar a partir de 2008, evidencio a importância das relações entre ativismos na consolidação de uma identidade política coletiva e de um modo de atuar que valoriza as interseccionalidades, fato pouco explorado pela literatura sobre movimento LGBTI, em particular, e sobre movimentos sociais, de modo geral.

Black, LGBTI and from the Favelas: The Impact of the Relationships between Movements in the Consolidation of Intersectional Activisms

Abstract: In this article, based on an ethnographic investigation carried between 2015 and 2019, I address the impact of the relationships between social movements in the consolidation of an intersectional activism. The analysis is centered on the political networks of a black, peripheric and LGBTI organization: Aos Brados; founded in 1998 in Campinas (São Paulo, Brazil). Here, I demonstrate how, while moving through a web that connects different movements, the group reframes notions and practices circulating in this network. Through the analysis of the cultural activities that the group organizes since 2008, I reveal the significance of the relationships between social movements in the strengthening of a collective political identity and a form of acting that invests in intersectionality; a fact underexplored in the literature.

Keywords: Social Movements, LGBTI Movement, Black Movement; Intersectional Activism
La Marcha del Orgullo en El Salvador: (Re)Construcción de la memoria, del mito fundador a la realidad histórica
Authors: Maire Thierry
Published: September 2021

La Marcha del Orgullo en El Salvador, la más antigua del istmo centroamericano, tiene su narrativa anclada en un hecho histórico nacional, estrechamente ligado a la guerra civil que abrumó al país durante los años 80. El concepto de las marchas deriva de los acontecimientos de EE. UU. Entonces, ¿por qué la marcha salvadoreña se presenta como una manifestación de conmemoración de un hecho nacional más que en relación con su antecesora estadounidense, particularmente en un país tan dependiente del gigante del Norte? Para responder a ese cuestionamiento, investigué qué tanto los miembros de la diversidad sexual en San Salvador conocen sobre la historia de su marcha, de su relación con ese hecho nacional y de la Gay Pride (Orgullo Gay) neoyorkina. Agregué a ese análisis cuantitativo llevado a cabo a través de una encuesta en línea, una investigación biográfica alrededor de los fundadores de la marcha. Los vínculos directos, aunque desvanecidos y a veces negados, que los ligan con EE. UU., bien podrían explicar cómo se ideó realmente la Marcha del Orgullo. La narrativa actual procede, entonces, de una re(construcción histórica de la marcha, parcialmente por razones estratégicas, en respuesta al discurso opositor de la derecha conservadora del país.

The ‘Marcha del Orgullo’ in El Salvador: (Re)Building Memory, from the Founding Myth to the Historic Reality

Abstract: The ‘Marcha del Orgullo’ in El Salvador, the oldest in Central America, is supposed to have been founded in tribute to trans people kidnapped and slaughtered during the Civil War in the 80’s. Nonetheless the mere concept of Gay Prides marches took its origin in those realized in the US. Why is it then that El Salvador one should be more autonomous in its foundation? That is especially nagging when one considers the closeness of El Salvador to the US. To solve this enigma, I first undertook an online survey among members of the lgbtiq community in San Salvador, to look at what they knew about the historical narration of their national Pride. I then investigated more into the personalities of the founders of the event. I discovered some very direct relations between them and US-related activists and NGO, which could explain the foundation of the Salvadorian Pride, but I also came to understand why the narrative of the event is framed in order to suppress this US influence due to the opposite stance of far-right conservatives activists.

Keywords: El Salvador, Pride parade, human rights, LGBT, sexual diversity.
Liderazgos interculturales en América Latina: desigualdades persistentes y resistencias comunitarias, como alternativas durante la pandemia de COVID-19
Authors: De Sousa Teodora , Paillafil Calfulen Juan , Mejía Rossana , Suárez Jeiser , Espinoza Serafina , Torres Morales Gabriela , Pagano Gaia , Tubino Fidel , Campos Melo María Antonieta , De Souza Hellen , Zapata Webb Yuri Hamed
Published: September 2021

La desigualdad socioeconómica en América Latina ha modelado múltiples dinámicas de la vida social en la región. Actualmente, estas se han visto intensificadas en el marco de la pandemia de COVID-19, generando graves consecuencias sociales, económicas y sanitarias, con efectos diferenciados para las mujeres, las comunidades étnicas y los territorios rurales a lo largo de la región. Frente a ello, se relatan en el presente artículo cinco experiencias de liderazgo en comunidades étnicas de distintos países de América Latina; experiencias que, desde propuestas alternativas de resistencia comunitaria, han formulado iniciativas para la contención del virus y la crisis socioeconómica que sus comunidades han padecido en este contexto.

Intercultural leaderships in Latin America: durable inequalities and alternative community resistances during the pandemic of COVID-19

Abstract: Socioeconomical inequality in Latin America, has shaped multiple dynamics of the social life in the region. Nowadays, these have been intensified in the frame of the pandemic of COVID-19, generating severe social, economic, and sanitary consequences, with differentiated effects for women, ethnic communities, and rural territories in the region. As a result, in this article, there will be related five leadership experiences among ethnic communities of diverse Latin American countries; from where there has been constructed alternative solutions of community resistance, to contain the virus and the socioeconomical crisis that their communities have hold within the present context.

Key words: inequality, interculturality, community leadership, social resistance, pandemic.
Apuntes para un cuidado inmanente y despersonalizado. Entre la gestión del VIH y la del SARS-CoV-2
Authors: Cancino Barreto Jaime Sebastián
Published: September 2021

En este artículo exploro la normalización del cuidado impulsada por la gestión de dos pandemias en Colombia: las provocadas por el VIH y el SARS-CoV-2. Paralelo a ello brindo elementos para un cuidado-otro que tiene como rasgos su inmanencia —que también nombro habitar— y su dimensión despersonalizada. Con esto en mente, rastreo los procedimientos mediante los cuales las instituciones estatales reclaman el monopolio de la gestión de estas pandemias; allí ahondo en la obediencia que solicitan y en el obstáculo que esto representa para el surgimiento de este cuidado-otro. Más adelante estudio lo que llamo “patologización del virus”, explorando algunos de sus rasgos y los efectos políticos que traería, especialmente, la producción de un cuidado securitizado. Finalmente, me concentro en la alianza biopoder y capital, que cobra su mejor expresión en la disyuntiva “economía o vida” y que muestra que la protección biopolítica de la vida es también un hacer producir.

Notes for an immanent and depersonalized care. Between the management of HIV and of SARS-CoV-2

Abstract: This article explores the normalization of care driven by the management of two epidem- ics in Colombia: HIV and SARS-CoV-2. Parallel to this, it provides elements for a different care that has and would have as traits its immanence —which I also name inhabiting— and its depersonal- ized dimension. To do this, I trace the procedures by which state institutions claim a monopoly on the management of epidemic; there, I delve into the particular obedience they request and the obstacle that this is to inhabit a different care. Later, I will stop at what I call “virus pathologiza- tion”, exploring some of its features and the political effects it would bring, especially the building of securitized care. Finally, I will focus on the alliance between biopower and capital, which takes its best expression in the famous dilemma “economy or life”. That dilemma exposes that biopoliti- cal protection life is a “make produce” too.

Keywords: biopower, capital, care, HIV, SARS-CoV-2.
Challenges Experienced by Public Higher Education Institutions of Learning in the Implementation of Training and Development: A Case Study of Saudi Arabian Higher Education
Authors: Othayman Majed Bin , Meshari Abdulrahim , Mulyata John , Debrah Yaw
Published: September 2021

The present case study aimed to investigate challenges in learning in Saudi Arabia’s higher education institutions in the context of the implementation of training and development. A qualitative study design was used, and semi-structured interviews were conducted with 75 faculty members and human resource managers working in four public universities in Saudi Arabia. The interviews were recorded, and thematic analysis was applied to the collected data. On-campus and off-campus methods are used to implement training programmes in all four universities, regardless of the flaws of both types of training. Due to a lack of time, the majority of respondents indicated that their heavy teaching workload prevented them from engaging in university training and development. Multifactorial challenges are involved in the higher education institutions of learning with regards to the application of training and development in Saudi Arabia. One of the most significant obstacles that Saudi Arabian institution administrators face in their attempts to innovate and strengthen learning and teaching methods and methodologies is a shortage of qualified and domestic trained faculty. Because of contact breakdowns, hiring highly skilled and technically trained international teachers, for example, introduces language gaps and reduces the efficacy of teaching and learning processes. The key consideration is the execution of preparation and growth; universities have a smaller chance of achieving the goal value. With too much money being spent on training and growth, the question is not what organizations should prepare, but, rather, whether training is worthwhile and efficient.
Zoning fee in connection with an increase in the value of real property. Selected problems
Authors: Dobkowska Bogusława
Published: September 2021

An increase in the value of real property triggers, in some circumstances, the obligation on the part of the ownership title holder or perpetual usufructuary to pay a public levy to the commune. The issues of such mutual settlements between the owner of the real property and the commune arising from a change in the value of the real property have been regulated in the Act of 27 March 2003 on Spatial Planning and Development. Those fees include, among others, the so-called zoning fee which is discussed in this article. The analysis is based on views expressed by legal scholars in their writings, applicable legal acts and jurisprudence of administrative courts in this regard. The zoning fee and the legal issues related to its determination which raise the greatest doubts will be examined.
CLINICAL APPLICATIONS OF ELECTROCHEMOTHERAPY
Authors: Serša Gregor
Published: September 2021

Electroporation has several biomedical and industrial applications. The biomedical applications are in the field of drug or gene delivery. Electrochemotherapy utilizes electroporation for the increased delivery of cytotoxic drugs like bleomycin or cisplatin into tumors. The use of electrochemotherapy has spread throughout Europe for the treatment of cutaneous tumors or metastases. It is in the NICE guidelines and is becoming standard ablative technique in treatment of cancer. The technological advancements have also enabled the use of electrochemotherapy for the treatment of deep seated tumors, such as soft tissue or liver tumors. Clinical studies demonstrate good effectiveness on fibrosarcomas, colorectal liver metastases and hepatocellular carcinoma. However, electrochemotherapy is a local treatment that also induces moderate local immune response. This so called “in situ vaccination” induced by electrochemotherapy can be exploited in combined treatment with immune checkpoint inhibitors or electrogene therapy with immunostimulating effect. Therefore, gene electrotransfer of plasmid coding for interleukin 12 (IL-12), in combination with electrochemotherapy could result in transformation of electrochemotherapy from local into systemic treatment. This is also of our current interest, and we are undertaking steps to bring this idea from preclinical into clinical testing.
HYPERTENSION – A PUBLIC HEALTH PROBLEM
Authors: Pilav Adia , Tanović-Mikulec Emira , Branković Suada , Đido Vedran
Published: September 2021

Aim. The aim of this paper is to present public health importance of hypertension in population as one of the major CVD risk factor as well as a model of integrated approach to hypertension control at community level. Background. In spite of wide knowledge of pathophysiology and epidemiology in development of hypertension, ability to easily diagnose it, availability of efficient medications, hypertension continues to have high prevalence and setting up hypertension controls poses significant public health challenge. High prevalence of hypertension exists in all countries of the world, regardless of socioeconomic status of the country. It is estimated that the number of people with hypertension by 2025 will rise by 15-20%, and the number of sick people will increase up to 1.5 billion people worldwide. Methods. A review of the relevant literature which discusses the importance of defining clear strategies and interventions in the control of hypertension in countries, with particular emphasis on integrated hypertension management that has the greatest impact. Discussion. Effective and efficient hypertension control requires two approaches: population approach and individual approach to high-risk individuals. The balanced combination of population approach and an approach to access high-risk individuals is vital for the effective control of hypertension and cardiovascular diseases. Conclusions. Health systems in every country must be flexible and ready to provide adequate model of integrated approach to hypertension control at community level understanding their own local needs.
DCluster: Geospatial Analytics with PoI Identification
Authors: S. Capanema Cláudio Gustavo , A. Silva Fabrício , M. Braga Silva Thais R. , F. Loureiro Antonio A.
Published: September 2021

The generation of geospatial data is an inherent aspect for several applications that aim to track people, automobiles, or other mobile objects. Mining information from this type of data is a crucial factor for the development of Smart Cities. In many cases, it can help improve human mobility and the quality of citizens. In this sense, there is a growing demand for systems capable of extracting information from several data types, including the geospatial one. In this work, we present DCluster, a web system that aims to assist data analysts in exploring and visualizing the main types of data, including the geospatial one. Additionally, DCluster has the capability of discovering points of interest based on data of mobile users and classifying them as Home, Work, and Other locations. Data analysts can take advantage of DCluster to explore their data and extract knowledge from it.
The Social History of Law as a Factor of the Rule of Law
Authors: Fogelson Yury , Poldnikov Dmitry
Published: September 2021

The rule of law, understood as ideology and legal rules, is believed to be a competitive advantage of Western civilization, supporting its sustainable development. Yet it can also be viewed as a social norm of citizens who respect the law and follow its commands. How does this social norm emerge in different societies? This question must be answered through the social history of the law in Western and non-Western societies from a comparative perspective. This paper outlines the main features of comparative socio-legal history and tests it on some significant historical examples. In the first part of the article, the authors propose a functional classification of legal systems into three ideal Weberian types-the law of judges, learned law, and the law of the authorities. It allows us to consider the origin of the social norm of the rule of law. In the second part of the article, the authors trace the transition from the ideal types to natural legal systems and identify the factors that determine the stability of the social norm of the rule of law where it originated. In the final part of the article, the authors conclude that, first, the social norm of the rule of law emerged in the societies where the law had been treated either as a means of resolving disputes (the law of judges) or as the rules of fair, correct conduct (learned law), for example, the Roman Republic, medieval England, continental Europe, and the Ottoman Empire. Secondly, the stability of the social norm of the rule of law seems to be explained by a "triangle" of factors, namely: 1) political competition where all participants understand the inevitability of compromise on the basis of the law, 2) law which is suitable for finding a compromise due to its internal merits, 3) a professional community of jurists who develop and apply law independently of the administration. Such a triangle is possible in any society where the law of judges or learned law prevails and where the majority of participants in the political process are ready to compromise based on the current law. / JEL Classification: K 10; K 11; K 12
Rechtlicher Inhalt der Institutionalisierung von Eigentum und ihre Auswirkungen auf die Entwicklung der Gesellschaft und des Staates
Authors: Tleulesova Bagila
Published: September 2021

Institutionalizing ‘property’ as well as defining the term ‘property’ adequately are broadly discussed problems among legal scholars. This article presents several approaches to the institutionalization of ‘property’ and discusses several theoretical and historical concepts of the term. The article concludes that the right to property and its regulation as well as a robust, stable and effective legal system of protecting the right to property are instrumental to the successful development of a modern state.
Postwachstumsökonomie: Von der aussichtslosen Institutionen- zur Individualethik
Authors: Paech Niko
Published: September 2021

Mit der Einsicht, dass eine Entkopplungs- oder Green-Growth-Strategie keine Option darstellt, erweist sich ein Ökonomieentwurf als unerlässlich, der nicht auf Vermehrung, sondern Reduktion und Selbstbegrenzung menschlicher Möglichkeiten basiert. Die notwendige Transformation ist unter aktuellen kulturellen Bedingungen mit einem institutionenethischen Ansatz kaum vereinbar. Erfolgversprechender sind individualethische Konzepte, die zivilgesellschaftliche Veränderungsimpulse aufgreifen.
Selbstreflexion für ein professionelles Konfliktmanagement: Ein Ansatz für die polizeiliche Bildungsarbeit
Authors: Staller Mario S. , Koerner Swen , Zaiser Benjamin
Published: September 2021

Reflexion und Reflexivität sind wichtige Bestandteile einer professionellen Praxis im polizeilichen Tätigkeitsfeld. Der vor­ liegende Beitrag legt dar, dass Reflexivi­tät über ein bloßes Nachdenken hinaus­ geht und beschreibt eine Struktur der Reflexion auf drei Ebenen, welche mit jeweils anderen Kernfragen verbunden sind. Während auf niederschwelliger Reflexionsebene die Frage nach der kor­rekten Handlung im Mittelpunkt steht, dreht sich die Reflexion auf einer höhe­ren Ebene um das Aufdecken der eigenen handlungsleitenden Annahmen, welche das Handeln (un­)bewusst beeinflussen sowie um die Möglichkeit zur Einnahme von anderen Perspektiven. Das Durch­laufen der drei Reflexionsebenen ist für den/die reflektierte/n Praktiker*in und hier besonders für das Konfliktmanage­ ment als Einsatzkraft eine notwendige Voraussetzung.
COVID-19 and Cardiovascular Disease: Mechanisms and Implications
Authors: Mitevska Irena
Published: September 2021

We are living and fighting serious COVID-19 pandemic, which is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Cardiovascular diseases are highly prevalent in the infected individuals, which modifies their treatment and prognosis. The injury of the myocardium is reported in over 15% of hospitalized severely ill patients, mostly presented in the form of acute heart failure, acute coronary syndrome, cardiac arrythmias, myocarditis and thromboembolic complications. All these complications may appear at early in the course of the disease, during the disease progress or in the later stage of the COVID-19 disease. Thromboembolic complications accompany more severe cases, caused by excessive inflammation, platelet activation, endothelial dysfunction, and stasis. This new virus pandemic is a global challenge for health care system where we still have much to learn.
Plant growth regulator effects on sunflower parents and F1 hybrids
Authors: Chuiko Dmytro
Published: September 2021

The need for augmented sunflower production requires finding new meth­ods and improving existing cultivation technologies to increase performance and resistance to stresses. The low performance of breeding and seed production lines is among obstacles to the rapid introduction of new and modern sunflower hybrids into production. The study purpose was to evaluate the individual responses of self-pollinating sunflower lines intended for breeding and seed production and of F1 hybrids, which were developed by crossing these lines, to plant growth regulators. It was found that the CMS-based lines had better yield elements and oil content in response to growth regulators compared to the lines based on normal cytoplasm. The plant growth regulators increased the heterosis effect in the experimental hybrids. The best response was observed in the threeline hybrid Skh808A/Kh1002B × Kh785V for all the studied parameters. The growth regulators strengthened a correlation between the 1000-seed weight and yield (r = 0.51–0.97). The oil content in seeds of F1 hybrids depended on the genotype and could be comparable both with the parent with a low content of oil and with the high-oil parent. Variations in the oil content in seeds depended on the type of growth regulator and soil/climatic conditions during the seed filling.
REAL-TIME PCR TO IDENTIFY PORCINE DNA IN PROSTHODONTIC MATERIALS
Authors: HUTASOİT Ismail , PRANATA Agy , WİYAH Masna , RAMADHANİ Fitri , NASUTİON Hubban
Published: September 2021

Objectives: This study aimed to identify porcine DNA in prosthodontic materials using Real-Time PCR.
Materials and methods: Eighteen prosthodontic materials: three irreversible hydrocolloids, three elastomers, three denture adhesives, three soft denture linings, three temporary crowns, and three denture bases materials were used as the samples. It was conducted in two stages. First, extraction of dental material’s DNA and the second was Real-Time PCR analysis based on amplification curve and Ct score in yellow and green channel.
Results: The sample analysis based on green channel demonstrated that all materials did not contain porcine DNA, however, 11 of 18 samples (DA-01, DA-02, DA-03, SDL-02, DB-01, DB-02, TC-03, IH-02, EM-01, EM-02, and EM-03) contained vertebrate DNA. Conclusions: All prosthodontic materials tested were not containing porcine. The halal statues of the materials were still unclear.
Construction of competing endogenous RNA interaction network as prognostic markers in metastatic melanoma
Authors: He Zan , Xin Zijuan , Peng Yongfei , Zhao Hua , Fang Xiangdong
Published: September 2021

Malignant melanoma (MM) is a malignant tumor originating from melanocytes, with high aggressiveness, high metastasis and extremely poor prognosis. MM accounts for 4% of skin cancers and 80% of mortality, and the median survival of patients with metastatic melanoma is only about 6 months, with a five-year survival rate of less than 10%. In recent years, the incidence of melanoma has gradually increased and has become one of the serious diseases that endanger human health. Competitive endogenous RNA (ceRNA) is the main model of the mechanism by which long chain non-coding RNAs (lncRNAs) play a regulatory role in the disease. LncRNAs can act as a “sponge”, competitively attracting small RNAs (micoRNAs; miRNAs), thus interfering with miRNA function, and affect the expression of target gene messenger RNAs (mRNAs), ultimately promoting tumorigenesis and progression. Bioinformatics analysis can identify potentially prognostic and therapeutically relevant differentially expressed genes in MM, finding lncRNAs, miRNAs and mRNAs that are interconnected through the ceRNA network, providing further insight into gene regulation and prognosis of metastatic melanoma. Weighted co-expression networks were used to identify lncRNA and mRNA modules associated with the metastatic phenotype, as well as the co-expression genes contained in the modules. A total of 17 lncRNAs, six miRNAs, and 11 mRNAs were used to construct a ceRNA interaction network that plays a regulatory role in metastatic melanoma patients. The prognostic risk model was used as a sorter to classify the survival prognosis of melanoma patients. Four groups of ceRNA interaction triplets were finally obtained, which miR-3662 might has potential implication for the treatment of metaststic melanoma patients, and futher experiments confirmed the regulating relationship and phenotype of this assumption. This study provides new targets to regulate metastatic process, predict metastatic potential and indicates that the miR-3662 can be used in the treatment of melanoma.
Percepción social del aprovechamiento turístico en áreas naturales protegidas
Authors: Arroyo Arcos Lucinda , Moo Canul María de Jesús , Segrado Pavón Romano Gino
Published: September 2021

La percepción social puede constituirse en un factor influyente en la creación, promoción y ejecución de las políticas públicas de aprovechamiento de los espacios naturales con uso turístico. El objetivo general del estudio fue evaluar los factores más influyentes en la percepción social de los residentes de la isla de Cozumel acerca del aprovechamiento turístico de las Áreas Naturales Protegidas. Se aplicó un enfoque cuantitativo, con la técnica de encuesta y una muestra aleatoria representativa por conglomerados, para evaluar la percepción de impactos hacia la naturaleza, el aprovechamiento sustentable y el turismo, con un modelo de ecuaciones estructurales. Los resultados revelan una percepción negativa sobre el aprovechamiento turístico de las Áreas Naturales Protegidas, pero se reconocen los beneficios económicos y una preocupación social por la conservación. El factor más influyente en la percepción de la población sobre los impactos positivos de las Áreas Naturales Protegidas fue “Beneficios del turismo”. Se concluye que los beneficios económicos son el factor predominante en la percepción social de la población de Cozumel. Se sugiere que las políticas públicas de aprovechamiento turístico deben incentivar programas educativos que expliquen la relación entre conservación y beneficios económicos.
O Futuro do turismo no Brasil a partir da análise crítica do período 2000-2019
Authors: Lohmann Gui , Lobo Heros Augusto Santos , Trigo Luiz Gonzaga Godoi , Valduga Vander , Castro Rafael , Coelho Mariana de Freitas , Cyrillo Marina Wöhlke , Dalonso Yoná , Gimenes-Minasse Maria Henriqueta , Gosling Marlusa de Sevilha , Lanzarini Ricardo , Leal Sergio Rodrigues , Marques Osiris , Mayer Verônica Feder , Moreira Jasmine Cardozo , Moraes Lauro Almeida de , Panosso Netto Alexandre , Perinotto André Riani Costa , Queiroz Neto Ambrozio , Raimundo Sidnei , Sanovicz Eduardo , Trentin Fabia , Uvinha Ricardo Ricci
Published: September 2021

O presente artigo oferece uma perspectiva sobre o turismo no Brasil, analisando os principais desdobramentos com foco no período de 2000-2019. Trata-se de um artigo de opinião com reflexões de acadêmicos do turismo brasileiro. Os tópicos relacionados ao turismo, cobertos neste artigo, incluem economia, política e planejamento, marketing, transporte, meio ambiente, gastronomia, hospitalidade, lazer, entre outros. Como principal conclusão, considera-se que o Brasil não conseguiu se posicionar como destino de renome internacional, já que desde a década de 1990 os esforços para apoiar o desenvolvimento do turismo regional obtiveram sucesso apenas moderado. As crises econômicas, a instabilidade política, a violência e a corrupção foram entraves que afetaram consideravelmente o setor de turismo. A falta de uma abordagem coordenada entre os vários níveis de governo, a escassez de dados de turismo e uma campanha de marketing supra-governamental de longo prazo, entre outros fatores, fizeram com que o país perdesse várias oportunidades importantes na década de 2010 para se estabelecer como um dos principais destinos turísticos no mercado global.
Палысепиолы: о новом минерале семейства палыгорскит—сепиолит, "Природа"
Authors: Расцветаева Р.К.
Published: September 2021

Слоистые силикаты, в основе которых лежат трехслойные блоки протяженностью от бесконечных двумерных до бесконечных одномерных, широко распространены в природе. Здесь рассмотрены семейства с гибридными блоками, которые сочетают двумерные фрагменты с одномерными. Кристаллохимическое многообразие представителей семейства палысепиолов, объединяющего минералы группы палыгорскита, сепиолита и промежуточных между ними, обусловлено вариациями химического состава блоков, их геометрических характеристик, а также топологии и симметрии их расположения в структуре. Мы выполнили рентгеноструктурное исследование нового представителя палысепиолов — Ca-туперссуатсиаита из Намибии. Приводится его сравнение с другими минералами этого семейства.
НОВЫЙ АСТРОНОМИЧЕСКИЙ ЦЕНТР ГАИШ МГУ: КАВКАЗСКАЯ ГОРНАЯ ОБСЕРВАТОРИЯ, "Земля и Вселенная"
Authors: Шатский Н.И. , Татарников А.М. , Корнилов В.Г. , Потанин С. А. , ЧЕРЕПАЩУК А.М. , Белинский А.А. , Постнов К.А.
Published: September 2021

В декабре 2019 г. исполнилось 5 лет со дня официального открытия новой российской обсерватории – Кавказской горной обсерватории ГАИШ МГУ. В статье рассказано об истории строительства и устройстве обсерватории, ее главном инструменте – 2.5-м телескопе и его навесном оборудовании, первых полученных результатах.
«ЕМУ – ТАК МНОГО ТЯЖКИХ БЕД, ЧТО НИ В ОДНОМ РОМАНЕ НЕТ». «БРЮС» ДЖОНА БАРБОРА: КНИГИ II–IV, "Средние века"
Authors: Федосов Д.Г.
Published: September 2021

Джон Барбор (ок. 1320–1395) по праву признан основоположником литературы на шотландском языке (Scots). Его монументальная поэма «Брюс» – и стихотворный роман, и биография короля Скоттов Роберта I, и историческая хроника, ставшая национальным эпосом Шотландии. Ниже предлагается продолжение первого полного перевода этого выдающегося памятника на русский язык, с сопроводительной статьей и комментариями.
Detection of Lead (II) on a Boron-doped Diamond Electrode by Differential Pulse Anodic Stripping Voltammetry
Authors: Sylvestre Koffi Konan , Ollo Kambiré , Etienne Kouadio Kouakou , Jocelin Kimou Kouakou , Lassiné Ouattara
Published: September 2021

Lead, even in low concentrations, can be dangerous and toxic to humans and their environment. Due to the toxicity of this metal, an electroanalytical method has been developed for the direct quantitative determination of Pb2+. The Pb2+ detection was performed using Differential Pulse Anodic Stripping Voltammetry. The quantification of Pb2+ by these electrochemical methods was carried out on a boron-doped diamondmicro electrode in HNO3 medium (0.01 M). This work made it possible to efficiently detect lead with a detection limit equal to 0.052 μM and a quantification limit equal to 0.173 μM. This method made it possible to selectively detect and quantify the Pb2+ in the presence of other metals such as Cd2+ and Cu2+. In the presence of other metals, a recovery rate of 94.53% was observed. This value is close to the recovery rate obtained (98.6%) when the Pb2+ is alone in electrolyte.
Seed Health of Chickpea as Influenced by Different Packaging during Storage
Authors: Thakur Vijaysingh , Nawalagatti C. M.
Published: September 2021

A storage experiment was conducted to know the influence of cloth, gunny, high density polythene (HDPE), and vacuum packed bags on the seed health of chickpea for 18 months. To investigate, chickpea seeds were packed in all the bags and were kept in ambient conditions. During the storage period, there was a lot of fluctuation in moisture content of the seeds based on the relative humidity in cloth, gunny, and HDPE bags due to the pervious nature of packaging materials whereas, there was no moisture fluctuation in vacuum packed bags due to lower water vapor and oxygen transmission rate and higher thickness of polythene bag used for vacuum package. After 8 months of storage period, there was bruchids infestation to the seeds stored in cloth, gunny, and HDPE bags whereas, no bruchids infestation were seen to vacuum packed bag even after 18 months of storage but germination, root length, shoot length, seedling vigour index, seedling dry weight has reduced and mean germination time, electrical conductivity of seed leachates has increased due to seed aging.  Hence, vacuum packaging technology can be effectively used for storage of chickpea seeds for longer period without any aid of chemicals.
Characterization of Effect of Gamma Ray Induced Mutations on Morpho-Agronomic Traits of Dolichos Lablab (Lablab purpureus l.) Sweet
Authors: Kimno S. K. , Kinyua M. G. , PKania K. C. , Chepkoech E. , Ego A. K.
Published: September 2021

Lablab purpureus (L.) Synonym Dolichos lablab (L.) Sweet; is a minor and an important multipurpose legume. Despite this it classified as an orphaned crop hence few studies on its improvement have been undertaken. Limited studies have been carried out on use of mutation on dolichos improvement.  Four elite Lablab genotypes coded G1, B1, M5 and W7 were mutagenized with two doses of gamma radiation 300Gy and 400 Gy with objective to study the effect of mutation on various agronomical traits at M2 generation. Data on effect of irradiation on lablab was collected 10 randomly selected plants of on each plot .The traits evaluated were leaf length, leaf width, number of raceme per plant, raceme length, pod length, pod width, plant height, dry seed yield per plant and seed length  and seed width. For these traits mean of mutant plants was significantly different from mean of control plants at    P≤0.05. Mutant accessions of B1, M5 and W7 genotypes exhibited wide mutation spectra after mutagenesis of albino, leafiness, upright single stem, seedless pod, short dwarf pod, variegated leaf, variation in flower colour, variation in growth habit, leaf shape, seed colour. Gamma irradiation doses of 300 Gy and 400 Gy were potent in mutagenesis of the studied dolichos lablab. The agronomically diverse mutants are an important resource for dolichos improvement through breeding and genetic studies. Mutants with variegated leafs and flower colour can be used in the landscaping while those different seed colour could be used in the improvement of sensory and cooking qualities of other native dolichos lablab beans.
Plastic Degrading Microbes: A Review
Authors: Saritha B. , Sindgi Sanakausar A. , Remadevi O. K.
Published: September 2021

Plastic accumulation is the vital cause of environmental pollution and is an ever-increasing ecological threat. The sustainable use of synthetic polymers is one of the major challenges of the twenty- first century. The conventional techniques employed to degrade plastic in the environment are inadequate as it releases harmful by-products. One of the solutions for reducing the plastic pollution is biodegradation of plastic by using microorganisms. In the present review, we have analysed the potential of plastic degrading microbes reported by different investigators.
Pulmonary Embolism–Related Mortality in Patients With Cancer
Authors: Zuin Marco , Nohria Anju , Henkin Stanislav , Krishnathasan Darsiya , Sato Alyssa , Piazza Gregory
Published: February 2025

Importance

Acute pulmonary embolism (PE) is a major cause of morbidity and mortality in patients with cancer in the US and worldwide.

Objectives

To assess the trends in PE-related mortality from 2011 to 2020 among US patients with cancer across age, sex, ethnic and racial groups, urbanicity, and regionality.

Design, Setting, and Participants

This cohort study used the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research data system to determine national trends in age-adjusted mortality rates (AAMRs) due to acute PE among US patients with cancer aged 15 years or older from January 2011 to December 2020. Concomitant trends in cancer mortality and incidence that may have contributed to PE-related mortality were obtained from US Cancer Statistics. Data were analyzed from September to November 2024.

Exposure

PE-related mortality.

Main Outcomes and Measures

The primary outcome was PE-related deaths among individuals with cancer. AAMRs and cancer incidence were assessed using joinpoint regression modeling, expressed as an average annual percentage change (AAPC) with relative 95% CIs.

Results

From 2011 to 2020, a total of 27 280 194 individuals aged 15 years or older (13 897 519 male [50.9%]; 13 382 675 female [49.1%]) died in the US. The AAMR for PE-related mortality in patients with cancer increased during this time period (AAPC, 2.5%; 95% CI, 1.4% to 3.6%; P = .001), without differences between sexes (P for parallelism = .38). The AAMR increased among those aged 15 to 64 years (AAPC, 3.2%; 95% CI, 1.9% to 4.6%; P = .001), non-Hispanic and non-Latinx White individuals (AAPC, 2.7%; 95% CI, 1.52% to 3.94%; P = .001), non-Hispanic and non-Latinx Black or African American individuals (AAPC, 2.2%; 95% CI, 0.7% to 3.7%; P = .001), Hispanic and Latinx individuals (AAPC, 2.6%; 95% CI, 0.7% to 4.5%; P = .006), and among individuals residing in the Southern US (AAPC, 3.7%; 95% CI, 1.3% to 6.2%; P = .003). During the same period, age-adjusted cancer incidence and cancer-related mortality decreased while the absolute number of new cancer diagnoses and cancer-related deaths increased.

Conclusions and Relevance

This cohort study found that despite decreases in cancer-related mortality rates, age-adjusted PE-related mortality in US patients with cancer increased over the last decade; concerning trends included rising PE-related mortality in younger individuals aged 15 to 64 years, particular ethnic and racial groups, and the Southern region of the US. Recognition of such patterns may inform further research into thromboprophylaxis and treatment of PE as a complication of cancer and cancer-directed therapy.
How (Ultra‐)Rare Gene Variants Improve Our Understanding of More Common Autoimmune and Inflammatory Diseases
Authors: Belot Alexandre , Tusseau Maud , Cognard Jade , Georgin‐Lavialle Sophie , Boursier Guilaine , Hedrich Christian M.
Published: February 2025

The aim of this study was to explore the impact of rare and ultra‐rare genetic variants on the understanding and treatment of autoimmune and autoinflammatory diseases with a focus on systemic lupus erythematosus (SLE) and Behçet syndrome. This review summarizes current research on the monogenic causes of SLE and Behçet syndrome, highlighting the various pathways that can be responsible for these unique phenotypes. In monogenic SLE, the identification of complement and DNASE1L3 deficiencies has elucidated mechanisms of apoptotic body accumulation and extracellular nucleic acid sensing. Type I interferonopathies underline the specific role of DNA/RNA sensing and the interferon overexpression in the development of systemic autoimmunity. Other significant genetic defects include Toll‐like receptor hypersignaling and JAK/STATopathies, which contribute to the breakdown of immune tolerance. To date, genetic defects directly affecting B and T cell biology only account for a minority of identified causes of monogenic lupus, highlighting the importance of a tight regulation of mechanistic target of rapamycin and RAS (Rat sarcoma GTPase)/MAPK (mitogen‐activated protein kinase) signaling in lupus. In Behçet syndrome, rare variants in TNFAIP3, RELA, and NFKB1 genes have been identified, underscoring the importance of NF‐κB overactivation. Additional monogenic diseases such as ELF4, WDR1 mutations and trisomy 8 further illustrate the genetic complexity of this condition. Observations from genetic studies in SLE and Behçet syndrome highlight the complexity of systemic inflammatory diseases in which distinct molecular defects caused by single‐gene mutations can promote lupus or Behçet syndromes, often unrecognizable from their genetically complex “classical” forms. Insights gained from studying rare genetic variants enhance our understanding of immune function in health and disease, paving the way for targeted therapies and personalized medicine.
Skin‐Inspired, High‐Resolution, Intelligent Aerosol Jet 3D‐Printed Palmtop with Multisensory Integration
Authors: Sinha Anoop Kumar , Goh Guo Liang , Jaw Wei Qi , Chen Guanbo , Pothunuri Laya , Yeong Wai Yee , Cai Yiyu
Published: February 2025

Electronic skin (E‐skin) with multimodal sensing demonstrates significant capability in acquiring object characteristics grasped by robotic artifacts. As the spatial resolution of the sensing nodes increases on the E‐skin, it introduces challenges related to compact design and wiring. Herein, the design, fabrication, and characterization of an ultrathin, ultralow cost, highly compact, and flexible multimodal sensing hierarchical palmtop with 390 piezoresistive tactile pressure sensing nodes and 5 capacitive hydration sensing nodes are presented. Each tactile pressure sensing node consists of two 3D‐printed Ag nanoparticle ink electrodes sandwiching a piezoresistive film. The hydration sensing nodes in contrast are capacitive type with 3D‐printed Archimedean spiral Ag nanoparticle ink electrodes. Upon characterization, the pressure sensors exhibit a sensitivity of 1.188 kPa−1 and an impressive sensing range from 10 to 600 kPa. Meanwhile, the hydration sensing nodes display a sensitivity of 3.124 per percentage increase in hydration level, with a hydration sensing range of 25%–75%. Subsequently, machine learning is used to discriminate the region touched on the palmtop, object shapes, and hydration levels. Given its multifaceted capabilities, this palmtop is poised to find potential applications in various robotic contexts such as robotic hands, rehabilitation hand exoskeletons, and in the sphere of augmented reality.
Using Spinodal Decomposition to Investigate Diffusion Enhancement and Vacancy Population
Authors: Chen Xinren , De Geuser Frédéric , Kwiatkowski da Silva Alisson , Liu Chuanlai , Woods Eric , Ponge Dirk , Gault Baptiste , Raabe Dierk
Published: February 2025

Material sustainability requires energy‐efficient and rapid strengthening processes. In alloys, strengthening through diffusion‐driven precipitation is limited by the low vacancy concentration, with fewer than one vacancy per 100 billion lattice sites at room temperature in metals such as aluminum and iron under thermodynamic equilibrium. Artificially increasing vacancy concentrations by 1 to 7 orders of magnitude above equilibrium levels through quenching, irradiation, or deformation can significantly accelerate material strengthening. However, measuring vacancy concentrations below 10−7 in alloys and achieving spatial mapping remain challenging. Here, a vacancy‐mediated gradient microstructure near grain boundaries is reported and analyzed to investigate diffusion enhancement and the local vacancy population in an Al‐Zn system. This method uses cryogenic processes to preserve excess vacancies and halt microstructure evolution, enabling intermittent measurement of compositional fluctuations during ultrafast spinodal decomposition. It allows for the assessment of diffusion enhancement and determination of vacancy supersaturation in sub‐micrometer regions. Liquid nitrogen–quenched Al–12.5 at.% Zn alloy shows a vacancy concentration of ≈10−7 at room temperature, dropping to 10−9 after 3 h, with significant spatial variation near grain boundaries. This work addresses gaps in understanding the evolution and distribution of vacancies across various measurement scales, advancing the control of vacancies to enhance the strengthening of engineering alloys.
The Crosstalk with CXCL10‐Rich Tumor‐Associated Mast Cells Fuels Pancreatic Cancer Progression and Immune Escape
Authors: Yin Hanlin , Chen Qiangda , Gao Shanshan , Shoucair Sami , Xie Yuqi , Habib Joseph R. , He Taochen , Gan Wei , Wang Juan , Zhang Lei , Xu Huaxiang , Shi Chenye , He Junyi , Wang Wenquan , Jin Yun , Goggins Michael G , Liu Liang , Lou Wenhui , Wu Wenchuan , Yu Jun , Pu Ning
Published: February 2025

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, necessitating approaches to improve prognosis. As the mediator of allergic process, mast cells have been found in various cancers and are associated with survival. However, the biological behaviors of tumor‐associated mast cells (TAMCs) remain unclear. Herein, an excessive infiltration of TAMCs in PDAC is demonstrated, which apparently associated with poor survival in PDAC patients. PDAC cells are found to recruit CXCR2+ MCs into TME, and then inhibited MCs ferroptosis, and maintained their proliferation. Concomitantly, the tumor‐derived exosome miR‐188‐5p activated the PTEN/AKT/GSK3β signaling, further stabilized transcriptional factor ERG by inhibiting its ubiquitin degradation, and finally enhanced the transcription of cxcl10 within TAMCs. In reverse, TAMCs‐derived CXCL10 reversely promoted tumor epithelial‐mesenchymal transition and induced immunosuppressive tumor microenvironment by recruiting CXCR3+ Tregs. Sodium cromoglycate (SCG) is a membrane stabilizer for MCs and confirmed as an effective and widely used agent to block TAMCs‐derived CXCL10 and further sensitize the therapeutic efficacy of anti‐PD‐1 antibody plus gemcitabine for PDAC. These findings illuminate a critical and innovative crosstalk between TAMCs and PDAC cells that promote PDAC progression, and SCG sensitizes PDAC to the current immuno‐chemotherapy, which reveals its potential to be a valuable adjuvant for PDAC patients.