bluuebunny/crossref_metadata_2025 huggingface dataset:
Mental Health and Substance Use Disorders in Transplant Waitlist, VAD, and Heart Transplant Patients: A TriNetX Database Analysis
Authors: Grzyb Chloe , Du Dongping , Mahesh Balakrishnan , Nair Nandini
Published: May 2024

Background/Objectives: Mental health and substance use disorders (MHDs and SUDs) affect cardiac allograft and VAD recipients and impact their quality of life and compliance. Limited research currently exists on MHDs and SUDs in this population. Methods: This study compares the incidence of MHDs and SUDs in the transplant list, VAD, and post-transplant patients with that in heart failure patients. Study cohorts were derived from the TriNetX database using ICD-10 codes. Differences in incidence were examined using the log-rank test. Adults with MHDs and SUDs before the window of time were excluded. All comparisons were made between propensity-matched cohorts. Statistical significance was set at p < 0.05. Results: Transplant waitlist patients showed a significant increase in the incidence of anxiety, depression, panic, adjustment, mood, alcohol use, and eating disorders. Post-transplant patients showed a significant increase in depression and opioid use. VAD patients showed a significant increase in depression and a decrease in panic disorder and anxiety. These results allow for further investigations on prevention and coping strategies. Conclusions: The deterioration of mental health can significantly impact medication compliance, survival, and quality of life. Opioid use for pain management in the early postoperative period should be further investigated to assess its impact on long-term substance use and addiction.
Venom Immunotherapy Does Not Affect Survival of Patients with Malignant Tumor in Poland
Authors: Chełmińska Marta , Specjalski Krzysztof , Jassem Ewa , Polańska Joanna , Kita Karolina , Górska Lucyna , Didkowska Joanna , Wojciechowska Urszula , Nittner-Marszalska Marita , Kuna Piotr , Kupczyk Maciej , Kruszewski Jerzy , Zakrzewski Aleksander , Czarnobilska Ewa , Stobiecki Marcin , Krenke Rafał , Dąbrowski Andrzej , Kwaśniewski Artur , Jarząb Jerzy , Bożek Andrzej , Bodzenta-Łukaszyk Anna , Łukaszyk Mateusz , Kowalski Marek , Smorawska-Sabanty Ewa , Fal Andrzej , Przybyłowska Katarzyna , Bartuzi Zbigniew , Pałgan Krzysztof , Niedoszytko Marek
Published: May 2024

Background: Allergen immunotherapy (AIT) is a well-established and efficient method of causative treatment for allergic rhinitis, asthma and insect venom allergy. Traditionally, a recent history of malignant neoplasm is regarded as a contraindication to AIT due to concerns that AIT might stimulate tumor growth. However, there are no data confirming that the silencing of the Th2 response affects prognosis in cancer. Objectives: The aim of this study was to investigate frequency of malignant tumors in patients undergoing AIT and the association between AIT and cancer-related mortality. Patients and Methods: A group of 2577 patients with insect venom allergy undergoing AIT in 10 Polish allergology centers was screened in the Polish National Cancer Registry. Data on cancer type, diagnosis time and patients’ survival were collected and compared with the general population. Results: In the study group, 86 cases of malignancies were found in 85 patients (3.3% of the group). The most common were breast (19 cases), lung (9 cases), skin (8 cases), colon and prostate cancers (5 cases each). There were 21 cases diagnosed before AIT, 38 during and 27 after completing AIT. Laplace’s crude incidence rate was 159.5/100,000/year (general population rate: 260/100,000/year). During follow-up, 13 deaths related to cancer were revealed (15% of patients with cancer). Laplace’s cancer mortality rate was 37.3/100,000/year (general population rate: 136.8/100,000/year). Conclusions: Malignancy was found in patients undergoing immunotherapy less often than in the general population. Patients with cancer diagnosed during or after AIT did not show a lower survival rate, which suggests that AIT does not affect the prognosis.
Comparison of Two Surgical Approaches for Coronary Artery Bypass of Left Anterior Descending Artery
Authors: Salamate Saad , Bakhtiary Farhad , Bayram Ali , Sirat Sami , Doss Mirko , Ciobanu Veaceslav , Monsefi Nadejda , El-Sayed Ahmad Ali
Published: May 2024

Background/Objectives: The minimally invasive approach through left mini-thoracotomy is a promising alternative to the median sternotomy for coronary artery bypass. The aim of this study was to compare the short-term outcomes of patients undergoing minimally invasive coronary artery bypass (MIDCAB) with off-pump coronary artery bypass through sternotomy (OPCAB) for single-vessel disease. Methods: From January 2017 to February 2023, 377 consecutive patients aged above 18 years undergoing off-pump bypass of the left anterior descending artery (LAD) with left internal thoracic artery underwent OPCAB. Propensity score matching was then applied. Primary endpoints were in-hospital mortality and 30-day mortality. Results: Prior to matching, 30-day mortality occurred in 2 (0.7%) patients in the MIDCAB group vs. 1 (1%) patient in the OPCAP group (p = 1). Transfusion of red blood cells (RBC) was required in 9.4% and 29% of patients within the MIDCAB and the OPCAB groups, respectively (p < 0.001). Median intensive care stay (ICU) was 1 [1–2] day in the MIDCAB group, vs. 2 [1–3] in the OPCAB (p < 0.001). In the matched cohort, 10% of MIDCAB patients received RBCs vs. 27.5% of OPCAB patients (p = 0.006). Median ICU stay was significantly lower in the MIDCAB group, 1 [1–2] vs. 2 [1–3] days. Conclusions: MIDCAB is as safe and effective as OPCAB for single coronary artery bypass of the LAD with the LITA in select patients. It is associated with a decreased ICU stay and lower transfusion rates when compared with OPCAB.
Dexmedetomidine as an Adjuvant to Nerve Block for Cancer Surgery: A Systematic Review and Meta-Analysis
Authors: Waloejo Christrijogo Soemartono , Musalim Dian Anggraini Permatasari , Budi David Setyo , Pratama Nando Reza , Sulistiawan Soni Sunarso , Wungu Citrawati Dyah Kencono
Published: May 2024

Background/Objectives: Our understanding of dexmedetomidine, as an adjuvant to nerve blocks in cancer surgery, is characterized by a current lack of compelling evidence, and it remains unknown whether the potential benefits of use outweigh the risks. The aim of the study was to evaluate the benefit and safety profiles of dexmedetomidine as an adjuvant to nerve blocks in cancer surgery. Methods: Systematic searches were conducted in MEDLINE, ScienceDirect, Cochrane Library, Springer, medRxiv, and Scopus up to 17 May 2024. Risk ratios (RR) for binary outcomes and standardized mean differences (SMDs) for continuous outcomes were quantified. Results: Twenty studies were identified. In breast cancer surgery, the use of dexmedetomidine reduced 24 h total morphine consumption (SMD = −1.99 [95% CI −3.01 to −0.98], p = 0.0001, I2 = 91%, random effects) and prolonged the requirement for morphine rescue analgesia (SMD = 2.98 [95% CI 0.01 to 5.95], p = 0.05, I2 = 98%, random effects). In abdominal cancer surgery, the dexmedetomidine group had lower total sufentanil consumption (SMD = −1.34 [95% CI −2.29 to −0.40], p = 0.005, I2 = 84%, random effects). Dexmedetomidine reduced the VAS score and decreased postoperative nausea and vomiting (PONV). No studies using dexmedetomidine reported serious adverse events. Conclusions: Using dexmedetomidine as an adjuvant to nerve blocks in cancer surgery could lower the VAS pain score and prolong the regional anesthesia duration, which would lead to a decrease in total opioid consumption and possibly contribute to fewer PONV events. Furthermore, the reports of no serious adverse events indicate its good safety profile.
Percutaneous Endovascular Reconstruction of the Common Femoral Artery and Its Bifurcation
Authors: Rassam Stephanie , Coscas Raphaël
Published: May 2024

Occlusive lesions of the common femoral artery (CFA) and its bifurcation have traditionally been treated with open surgery. Although long-term patency rates after open surgery are excellent, such repairs are associated with substantial local and general morbidity. In recent years, different treatment options have emerged within percutaneous endovascular repair. We hereby present a narrative review on endovascular treatment modalities and a treatment algorithm for endovascular revascularisation of the CFA and its bifurcation. Lesion analysis, access issues, vessel preparation tools, and types of repairs with or without the involvement of the bifurcation are described. Based on current data, an interventional approach can result in high technical success and acceptable mid-term patency rates. Further comparative evidence with open surgery and/or between the different types of endovascular repairs is required to improve the current treatment algorithm.
Modeling of Ethiopian Beef Meat Marbling Score Using Image Processing for Rapid Meat Grading
Authors: Erena Tariku , Belay Abera , Hailu Demelash , Asefa Bezuayehu Gutema , Geleta Mulatu , Deme Tesfaye
Published: May 2024

Meat characterized by a high marbling value is typically anticipated to display enhanced sensory attributes. This study aimed to predict the marbling scores of rib-eye, steaks sourced from the Longissimus dorsi muscle of different cattle types, namely Boran, Senga, and Sheko, by employing digital image processing and machine-learning algorithms. Marbling was analyzed using digital image processing coupled with an extreme gradient boosting (GBoost) machine learning algorithm. Meat texture was assessed using a universal texture analyzer. Sensory characteristics of beef were evaluated through quantitative descriptive analysis with a trained panel of twenty. Using selected image features from digital image processing, the marbling score was predicted with R2 (prediction) = 0.83. Boran cattle had the highest fat content in sirloin and chuck cuts (12.68% and 12.40%, respectively), followed by Senga (11.59% and 11.56%) and Sheko (11.40% and 11.17%). Tenderness scores for sirloin and chuck cuts differed among the three breeds: Boran (7.06 ± 2.75 and 3.81 ± 2.24, respectively), Senga (5.54 ± 1.90 and 5.25 ± 2.47), and Sheko (5.43 ± 2.76 and 6.33 ± 2.28 Nmm). Sheko and Senga had similar sensory attributes. Marbling scores were higher in Boran (4.28 ± 1.43 and 3.68 ± 1.21) and Senga (2.88 ± 0.69 and 2.83 ± 0.98) compared to Sheko (2.73 ± 1.28 and 2.90 ± 1.52). The study achieved a remarkable milestone in developing a digital tool for predicting marbling scores of Ethiopian beef breeds. Furthermore, the relationship between quality attributes and beef marbling score has been verified. After further validation, the output of this research can be utilized in the meat industry and quality control authorities.
Numerical Study on Electromagnetic Thermal Performance of Non-Metallic Armoured Optoelectronic Cable Winch System
Authors: Li Wenhua , Wu Huaizhao , Lin Shanying , Shen Weiwei , Lv Qingtao
Published: May 2024

Non-metallic armoured optoelectronic cable winch systems (NAOCWSs) play critical roles in facilitating signal transmission and powering subsea equipment. Due to the varying depths in these applications, deploying the entire cable length is unnecessary. However, the portion of the cable that remains coiled around the winch can generate an electromagnetic field, which may interfere with signal transmission and induce electromagnetic heating. This can lead to elevated temperatures within the system, affecting the cable’s lifespan. Consequently, this study examines the distributions of magnetic and temperature fields within the NAOCWS with different currents (10–30 A) and numbers of winding layers (1–10). Findings indicate that the magnetic flux density (MFD) changes periodically, and the period is closely related to the distance between the cables. At the centre of the cable, the flux density is minimum. Temperature distribution correlates with both current amplitude and the number of winding layers, where an increase in either parameter amplifies the temperature variance between the edge and intermediate cables within the same layer. The current does not affect the internal temperature distribution pattern. With the number of winding layers determined, the layer where the highest temperature of the system is located is well defined and does not vary with current.
Experimental and Numerical Investigations for Impact Loading on Platform Decks
Authors: Geng Baolei , Sun Keshuai , Gao Pu , Jin Ruijia , Jiang Shengchao
Published: May 2024

Experimental measurement and numerical simulations were carried out for investigating the impact loading behavior of platform decks under regular and irregular wave actions. In the numerical simulation section, a full-scale numerical wave tank was established using STAR-CCM+ software. A decreased tendency can be observed for an increased relative length of platform when the incident wave length is double the deck length. The increased deck height can also decrease impact loading on the platform, which is due to the platform being far away from the incident wave. Impact loading on the deck decreases with the increase in inclination angle, which can be explained by the deck bottom being directly exposed to the incident wave at negative inclination angles. Finally, the variation tendency of impact loading on platform decks under irregular wave actions is similar to that under regular wave actions, including the averaged values and significant values.
Population Genetic Structure of Sargassum horneri, the Dominant Species of Golden Tide in the Yellow Sea
Authors: Wang Xiaoran , Zhao Weiqian , Zhuang Minmin , Wu Tingjian , Zhao Chunyan , Dai Wei , Zhang Jianheng
Published: May 2024

Sargassum horneri golden tides are increasingly becoming a marine ecological problem in the Yellow Sea (YS) and East China Sea. To understand the genetic relationship between the attached S. horneri along the China coast and the floating biomass in the YS, we used partial rbcL, ITS2, cox1, cox3, and cob-cox2 to analyze the population genetic evolution of 165 Sargassum samples. The results showed that all samples were a single species of S. horneri. Partial sequences of each gene had major haplotypes, and other haplotypes evolved from the occurrence of base mutations. The cob-cox2 gene haplotype research showed only the attached samples from ZJ, LN, and KR contained Hap3, and the distribution proportions of Hap2 and Hap4 in SS and the YS were closest to the distribution of the attached samples from SD. These novel findings provided information about the genetic evolutionary relationship between attached S. horneri along the coast of China and floating S. horneri in the YS, as well as new ideas for tracing the source of floating S. horneri in the YS from a molecular biological perspective.
A Study on Fishing Vessel Energy System Optimization Using Bond Graphs
Authors: Moon Sang-Won , Ruy Won-Sun , Park Kwang-Phil
Published: May 2024

Recently, environmental regulations have been strengthened due to climate change. This change comes in a way that limits emissions from ships in the shipbuilding industry. According to these changes, the trend of ship construction is changing installing pollutant emission reduction facilities such as scrubbers or applying alternative fuels such as low sulfur oil and LNG to satisfy rule requirements. However, these changes are focused on large ships. Small ships are limited in size. So, it is hard to install large facilities such as scrubbers and LNG propulsion systems, such as fishing boats that require operating space. In addition, in order to apply the pure electric propulsion method, there is a risk of marine distress during battery discharge. Therefore, the application of the electric–diesel hybrid propulsion method for small ships is being studied as a compromised solution. Since hybrid propulsion uses various energy sources, a method that can estimate effective efficiency is required for efficient operation. Therefore, in this study, a Bond graph is used to model the various energy sources of hybrid propulsion ships in an integrated manner. Furthermore, based on energy system modeling using the Bond graph, the study aims to propose a method for finding the optimal operational scenarios and reduction ratios for the entire voyage, considering the navigation feature of each different maritime region. In particular, the reduction gear is an important component at the junction of the power transmission of the hybrid propulsion ship. It is expected to be useful in the initial design stage as it can change the efficient operation performance with minimum design change.
An Assessment of Landscape Perception Using a Normalised Naturalness Index in the Greater Seoul Area
Authors: Kim Doeun , Son Yonghoon
Published: May 2024

This study analysed the greater Seoul area (GSA) in terms of naturalness, a representative indicator of natural scenic beauty, and created an assessment map, shifting from a traditional urban development perspective to a landscape perspective. It also developed a “normalised naturalness index” by combining the results of the expert metric score with the Hemeroby index, which was used as a naturalness assessment representative item. Then, it interpreted the naturalness status of the GSA landscape characteristics. As a result, the landscape of the GSA demonstrates the following five characteristics: First, the central business districts in the capital city of Seoul are densely developed areas with a very high degree of human intervention. Second, the satellite cities built to solve Seoul’s housing and logistics problems are rated as “a little less, but still heavily humanised” as a landscape characteristic. These areas are becoming increasingly humanised. Also, it is worth noting that the third characteristic, regarding moderate landscape areas, has a distinctly different meaning for areas outside of the city boundary, as well as those within the city boundary. Although these areas are in the same statistical category, they have two different meanings: one is the area where the average values converged on “moderate” by virtue of urban forests near the city centre, and the other is the area outside of Seoul that has a Hemeroby value of 0.5–0.6, which refers to open spaces such as agricultural lands, wetlands, or coastal areas. Fourth, suburban forests are reserved with legal restrictions to curb excessive urban sprawl, as well as parts of the demilitarised zone along the border areas of North and South Koreas. The last landscape characteristic is illustrated in the scenic area of the eastern woodlands. The normalised landscape naturalness index developed through this study provides an overall understanding of the environmental state of the GSA. Future research may build on the results of this study to refine methods for assessing public perceptions of naturalness.
Evaluating Performance of Multiple Machine Learning Models for Drought Monitoring: A Case Study of Typical Grassland in Inner Mongolia
Authors: Wang Yuchi , Cui Jiahe , Miao Bailing , Li Zhiyong , Wang Yongli , Jia Chengzhen , Liang Cunzhu
Published: May 2024

Driven by continuously evolving precipitation shifts and temperature increases, the frequency and intensity of droughts have increased. There is an obvious need to accurately monitor drought. With the popularity of machine learning, many studies have attempted to use machine learning combined with multiple indicators to construct comprehensive drought monitoring models. This study tests four machine learning model frameworks, including random forest (RF), convolutional neural network (CNN), support vector regression (SVR), and BP neural network (BP), which were used to construct four comprehensive drought monitoring models. The accuracy and drought monitoring ability of the four models when simulating a well-documented Inner Mongolian grassland site were compared. The results show that the random forest model is the best among the four models. The R2 range of the test set is 0.44–0.79, the RMSE range is 0.44–0.72, and the fitting accuracy relationship could be described as RF > CNN > SVR ≈ BP. Correlation analysis between the fitting results of the four models and SPEI found that the correlation coefficient of RF from June to September was higher than that of the other three models, though we noted the correlation coefficient of CNN in May was slightly higher than that of RF (CNN = 0.79; RF = 0.78). Our results demonstrate that comprehensive drought monitoring indices developed from RF models are accurate, have high drought monitoring ability, and can achieve the same monitoring effect as SPEI. This study can provide new technical support for comprehensive regional drought monitoring.
Enhancing Urban Land Use Identification Using Urban Morphology
Authors: Lin Chuan , Li Guang , Zhou Zegen , Li Jia , Wang Hongmei , Liu Yilun
Published: May 2024

Urban land use provides essential information about how land is utilized within cities, which is critical for land planning, urban renewal, and early warnings for natural disasters. Although existing studies have utilized multi-source perception data to acquire land use information quickly and at low cost, and some have integrated urban morphological indicators to aid in land use identification, there is still a lack of systematic discussion in the literature regarding the potential of three-dimensional urban morphology to enhance identification effectiveness. Therefore, this paper aims to explore how urban three-dimensional morphology can be used to improve the identification of urban land use types. This study presents an innovative approach called the UMH–LUC model to enhance the accuracy of urban land use identification. The model first conducts a preliminary classification using points of interest (POI) data. It then improves the results with a dynamic reclassification based on floor area ratio (FAR) measurements and a variance reclassification using area and perimeter metrics. These methodologies leverage key urban morphological features to distinguish land use types more precisely. The model was validated in the Pearl River Delta urban agglomeration using random sampling, comparative analysis and case studies. Results demonstrate that the UMH–LUC model achieved an identification accuracy of 81.7% and a Kappa coefficient of 77.6%, representing an 11.9% improvement over a non-morphology-based approach. Moreover, the overall disagreement for UMH–LUC is 0.183, a reduction of 0.099 compared to LUC without urban morphology and 0.19 compared to EULUC-China. The model performed particularly well in identifying residential land, mixed-use areas and marginal lands. This confirms urban morphology’s value in supporting low-cost, efficient land use mapping with applications for sustainable planning and management.
Language Policy and Practices in an Ethiopian University towards Multilingualism
Authors: Chali Keresa Kumera , Parapatics Andrea
Published: May 2024

The study explores an Ethiopian higher education institution’s language policy and practices, explicitly focusing on multilingualism. Thе rеsеarch highlights a discrеpancy between languagе policy and classroom rеalitiеs. Despite English being officially designated as the primary instructional medium of higher education institutions, the prevalent environment for teaching and learning is multilingual, incorporating Afaan Oromoo, Amharic, and other languages alongside English. This disparity challеngеs thе monolingual languagе еducation policy mandatеd by thе Ethiopian constitution. The study employs a mixed-methods approach to offer a comprehensive perspective on the issue, stressing the necessity for a more holistic understanding of the situation. Furthеrmorе, thе rеsеarch indicatеs that thе Ethiopian constitution lacks еxplicit provisions addressing multilingualism within highеr еducation institutions, rеvеaling a gap in thе lеgal framework. This misalignmеnt calls for potential policy adjustmеnts to bеttеr accommodatе thе multilingual nature of highеr еducation. Bеyond thе classroom, both instructors and studеnts frеquеntly usе Afaan Oromoo, Amharic, and othеr hеritagе languagеs in thеir intеractions, furthеr еmphasizing thе importancе of undеrstanding thеsе languagе dynamics in thе Ethiopian highеr еducation contеxt. Ovеrall, this study undеrscorеs thе nееd for a closеr еxamination of languagе practicеs and thеir implications, offеring insights into promoting morе inclusivе еducation and informеd languagе policiеs within Ethiopian highеr еducation institutions.
Effect of GLP-1RA Treatment on Adhesion Molecules and Monocyte Chemoattractant Protein-1 in Diabetic Patients with Atherosclerosis
Authors: Hachuła Marcin , Basiak Marcin , Kosowski Michał , Okopień Bogusław
Published: May 2024

Cardiovascular disease (CVD) remains a prominent cause of global mortality, primarily driven by atherosclerosis. Diabetes mellitus, as a modifiable risk factor, significantly contributes to atherogenesis. Monocyte recruitment to the intima is a critical step in atherosclerotic plaque formation, involving chemokines and adhesion molecules such as selectins, ICAM-1, and MCP-1. Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are a promising group of drugs for reducing cardiovascular risk in diabetic patients, prompting investigation into their mechanisms of action. This interventional study enrolled 50 diabetes patients with atherosclerotic plaque, administering GLP-1RA for 180 days. Serum concentrations of MCP-1, ICAM-1, and L-selectin were measured before and after treatment. Anthropometric and biochemical parameters were also assessed. GLP-1RA treatment resulted in significant improvements in anthropometric parameters, glycemic control, blood pressure, and biochemical markers of liver steatosis. Biomarker laboratory analysis revealed higher baseline levels of MCP-1, ICAM-1, and L-selectin in diabetic patients with atherosclerotic plaque compared to healthy controls. Following treatment, MCP-1 and L-selectin levels decreased significantly (p < 0.001), while ICAM-1 levels increased (p < 0.001). GLP-1RA treatment in diabetic patients with atherosclerotic plaque leads to favorable changes in serum molecule levels associated with monocyte recruitment to the endothelium. The observed reduction in MCP-1 and L-selectin suggests a potential mechanism underlying GLP-1RA-mediated cardiovascular risk reduction. Further research is warranted to elucidate the precise mechanisms and clinical implications of these findings in diabetic patients with atherosclerosis.
Understanding the Influences of Multiscale Waviness on the Elastohydrodynamic Lubrication Performance, Part II: The Partial-Film Condition
Authors: Wang Yuechang , Liu Ying
Published: May 2024

This paper is the second part of a two-part report studying the responses of a typical point-contact elastohydrodynamic lubrication (EHL) system to multiscale roughness mimicked by wavy surfaces. The wavy surfaces are defined by three key parameters: amplitudes, frequencies, and directions. The previous Part I paper focuses on the full film lubrication condition, while the current paper focuses on the partial film regime where asperity contacts occur. A transient thermal EHL model simulates lubrication problems with different waviness parameters, loads, and speeds. The total number of simulations is 1600. Performance parameters, including the asperity contact ratio, minimum film thickness, maximum pressure, central point film thickness, central point pressure, mean film thickness, coefficient of friction (COF), and the maximum temperature rise, are obtained for each simulation. These performance parameters are post-processed in the same manner as those in the previous Part I paper. The influences of the waviness parameters, load, and speed values on the eight performance parameters are discussed.
Friction and Wear of Cutting Tools and Cutting Tool Materials
Authors: Liu Guoliang , Huang Chuanzhen , Wang Xiangyu , Zhao Bin , Ji Min
Published: May 2024

The friction between cutting tools and the workpiece/chip can significantly affect the tool wear, cutting force, cutting temperature, machined surface integrity, and machined parts’ service performance [...]
Practical Evaluation of Ionic Liquids for Application as Lubricants in Cleanrooms and under Vacuum Conditions
Authors: Keller Andreas , Karlson Knud-Ole , Grebe Markus , Schüler Fabian , Goehringer Christian , Epp Alexander
Published: May 2024

As part of a publicly funded cooperation project, novel high-performance lubricants (oils, greases, assembly pastes) based on ionic liquids and with the addition of specific micro- or nanoparticles are to be developed, which are adapted in their formulation for use in applications where their negligible vapor pressure plays an important role. These lubricants are urgently needed for applications in cleanrooms and high vacuum (e.g., pharmaceuticals, aerospace, chip manufacturing), especially when the frequently used perfluoropolyethers (PFPE) are no longer available due to a potential restriction of per- and polyfluoroalkyl substances (PFAS) due to European chemical legislation. Until now, there has been a lack of suitable laboratory testing technology to develop such innovative lubricants for extreme niche applications economically. There is a large gap in the tribological test chain between model testing, for example in the so-called spiral orbit tribometer (SOT) or ball-on-disk test in a high-frequency, linear-oscillation test machine (SRV-Tribometer from German “Schwing-Reib-Verschleiß-Tribometer”), and overall component testing at major space agencies (ESA—European Space Agency, NASA—National Aeronautics and Space Administration) or their service providers like the European Space Tribology Laboratory (ESTL) in Manchester. A further aim of the project was therefore to develop an application-orientated and economical testing methodology and testing technology for the scientifically precise evaluation and verifiability of the effect of ionic liquids on tribological systems in cleanrooms and under high vacuum conditions. The newly developed test rig is the focus of this publication. It forms the basis for all further investigations.
Deep Learning-Enhanced Small-Sample Bearing Fault Analysis Using Q-Transform and HOG Image Features in a GRU-XAI Framework
Authors: Dave Vipul , Borade Himanshu , Agrawal Hitesh , Purohit Anshuman , Padia Nandan , Vakharia Vinay
Published: May 2024

Timely prediction of bearing faults is essential for minimizing unexpected machine downtime and improving industrial equipment’s operational dependability. The Q transform was utilized for preprocessing the sixty-four vibration signals that correspond to the four bearing conditions. Additionally, statistical features, also known as attributes, are extracted from the Histogram of Oriented Gradients (HOG). To assess these features, the Explainable AI (XAI) technique employed the SHAP (Shapely Additive Explanations) method. The effectiveness of the GRU, LSTM, and SVM models in the first stage was evaluated using training and tenfold cross-validation. The SSA optimization algorithm (SSA) was employed in a subsequent phase to optimize the hyperparameters of the algorithms. The findings of the research are rigorously analyzed and assessed in four specific areas: the default configuration of the model, the inclusion of selected features using XAI, the optimization of hyperparameters, and a hybrid technique that combines SSA and XAI-based feature selection. The GRU model has superior performance compared to the other models, achieving an impressive accuracy of 98.2%. This is particularly evident when using SSA and XAI-informed features. The subsequent model is the LSTM, which has an impressive accuracy rate of 96.4%. During tenfold cross-validation, the Support Vector Machine (SVM) achieves a noticeably reduced maximum accuracy of 84.82%, even though the hybrid optimization technique shows improvement. The results of this study usually show that the most effective model for fault prediction is the GRU model, configured with the attributes chosen by XAI, followed by LSTM and SVM.
Human-Centered Design and Manufacturing of a Pressure-Profile-Based Pad for Better Car Seat Comfort
Authors: Naddeo Alessandro , Morra Alfonso , Califano Rosaria
Published: May 2024

A car seat’s function is to support, protect, and make passengers and drivers feel comfortable during a trip. A more uniform pressure distribution and a larger contact area usually provide less discomfort. Consequently, the seat pan’s material and geometry play an essential role in the design process. A shaped pad was opportunely designed and realized, starting from the pressure distributions between the buttocks and the seat pan; pressure data were acquired during an initial experiment involving 41 people, representing a wide range of percentiles. The shaped pad was compared with a standard one by building a special seat with an interchangeable internal pad and testing the standard and the new seat; the second experiment involved 52 people that tested both seats. The tests were conducted to assess comfort (33 subjects were asked to be seated for 1 min each) and discomfort (19 subjects were asked to be seated for 15 min each); during the tests, pressure distribution and contact area data were gathered. The results showed that, for both tests, about 80% of the participants, among which 100% of the female sample, preferred the shaped seat pan pad. Even if the material was exactly the same, the shaped pad seemed to be softer, more comfortable, and more suited to the body’s shape than the standard one. The design methodology was demonstrated to be very useful for granting a more uniform pressure distribution and a wider contact area, i.e., higher comfort and less discomfort.
Factors Associated with Discharge Destination in Patients with Bone Metastases
Authors: Himematsu Hanako , Shimizu Yukiyo , Yuhara Tami , Hiasa Kenta , Yamazaki Masashi , Hada Yasushi
Published: May 2024

Background and Objectives: The discharge destination of patients with advanced cancer correlates with their quality of life. Patients with bone metastases often undergo lifestyle changes owing to pain and activity limitations. However, there are few reports on factors related to the discharge destination of patients with bone metastases. This study aimed to elucidate the factors associated with the discharge destination of patients with bone metastases. Methods: This study included 278 patients diagnosed with bone metastases who were admitted to the University of Tsukuba Hospital between April 2015 and March 2020. This study examined discharge destination, occurrence of skeletal-related events (SREs), primary lesions, locations of bone metastases, functional ambulation categories (FAC), age, and length of hospital stay. A binomial logistic regression analysis was conducted to compare the home and non-home discharge groups. Results: Of the 278 patients, 142 were discharged to home, 89 were discharged to somewhere other than home (non-home), and 47 died. The discharge destination was associated with spinal cord compression (SCC) (odds ratio [OR] 3.37, 95% confidence interval [CI] 1.35–8.43), hypercalcemia (OR 6.84, 95% CI 1.09–42.76), and FAC at admission (OR 0.45, 95% CI 0.35–0.58). The admission FAC cut-off value for discharge to home was determined to be 1.5 (area under the curve [AUC] 0.79, sensitivity 77.5%, specificity 68.5%). Conclusions: Factors associated with discharge destination were identified. The walking ability required for discharge to home was FAC 1.5, meaning that the patient needed one person to assist in preventing falls when walking on level ground. A cut-off value for FAC on admission for predicting outcomes was identified, suggesting the importance of gait ability assessment on admission.
Influence of Aortic Arch Morphology on Renal Perfusion in Patients with Coarctation of the Aorta: An Exploratory Study
Authors: Cesna Sigitas , Bielinis Augustinas , Zvirblis Tadas , Miglinas Marius , Tarutis Virgilijus
Published: May 2024

Objectives: The configuration of the aortic arch, particularly a Gothic arch shape, in individuals with corrected coarctation of the aorta (CoA) has been associated with a decreased systolic wave amplitude across the arch, which could potentially impair renal perfusion and elevate the risk of arterial hypertension. This study aims to explore the relationship between the morphological characteristics of the aortic arch and their impact on renal perfusion in patients with CoA. Methods: Seventy-one subjects with corrected CoA underwent continuous 24 h ambulatory blood pressure monitoring, computed tomography to assess the aortic arch, and renal perfusion scanning. Subjects were stratified into three groups based on the height-to-width (H/W) ratio of their aortic arch: Group 1 with a H/W ratio of <0.65, Group 2 with a H/W ratio between 0.65 and 0.85, and Group 3 with a H/W ratio of >0.85. Results: Groups 1 and 2 (53,78% and 62.63%) presented with a higher hypertension prevalence of elevated blood pressure than Group 3 (38.89%). Notable variations were observed among the subjects in the time to peak perfusion (Tmax) in the left kidney across the groups. Group 1 showed a median Tmax at 0.27, Group 2 at 0.13, and Group 3 at −0.38 (p-value = 0.079). The differences in Tmax for the right kidney followed a similar trend but were not statistically significant (Group 1 at 0.61, Group 2 at 0.22, and Group 3 at 0.11; p-value = 0.229). Conclusions: This study suggests that variations in the aortic arch morphology might not significantly influence renal perfusion in CoA patients. This indicates the potential adaptability of the renal blood flow, which appears to compensate for reduced perfusion, thus minimizing adverse effects on the kidney function. This adaptability suggests an inherent physiological resilience, emphasizing the need for further targeted research to understand the specific interactions and impacts on treatment strategies for CoA.
Hesperidin, a Potential Antiviral Agent against SARS-CoV-2: The Influence of Citrus Consumption on COVID-19 Incidence and Severity in China
Authors: Kowalczyk Adam
Published: May 2024

This review examines hesperidin, a citrus bioflavonoid, as a potential antiviral agent against SARS-CoV-2. The COVID-19 pandemic has demanded an urgent need to search for effective antiviral compounds, including those of natural origin, such as hesperidin. The review provides a comprehensive analysis of the chemical properties, bioavailability and antiviral mechanisms of hesperidin, particularly its potential efficacy against SARS-CoV-2. A review of databases, including PubMedPico, Scopus and Web of Science, was conducted using specific keywords and search criteria in accordance with PRISMA (Re-porting Items for Systematic Reviews and Meta-Analysis) guidelines between 2020 and 2024. Of the 207 articles, 37 were selected for the review. A key aspect is the correlation of in vitro, in silico and clinical studies on the antiviral effects of hesperidin with epidemiological data on citrus consumption in China during 2020–2024. The importance of integrating laboratory findings with actual consumption patterns to better understand the role of hesperidin in mitigating COVID-19 was highlighted, and an attempt was made to analyze epidemiological studies to examine the association between citrus juice consumption as a source of hesperidin and the incidence and severity of COVID-19 using China as an example. The review identifies consistencies and discrepancies between experimental and epidemiological data, highlighting the need to correlate the two fields to better understand the potential of hesperidin as an agent against SARS-CoV-2. Challenges and limitations in interpreting the results and future research perspectives in this area are discussed. The aim of this comprehensive review is to bridge the gap between experimental studies and epidemiological evidence and to contribute to the understanding of their correlation.
Assessing the Impact of Bilingualism on the Linguistic Skills of Children with Autism Spectrum Disorder (ASD) in Greece: A Scoping Review
Authors: Papadopoulos Angelos , Prentza Alexandra , Voniati Louiza , Tafiadis Dionysios , Trimmis Nikolaos , Plotas Panagiotis
Published: May 2024

(1) Background and Objectives: This review aims to identify the latest literature on the possible effect of bilingualism on the linguistic skills of children with autism spectrum disorder (ASD) residing in Greece. (2) Materials and Methods: The literature was searched in the databases of Scopus and PubMed by selecting articles and by reviewing four studies published in peer-reviewed journals. This Scoping Review is based on the standards of PRISMA recommendations for scoping reviews, while the PCC framework was used as a guide to construct clear and meaningful objectives and eligibility criteria. (3) Results: The publications included in the review addressed a variety of language-related skills, including morphology, the syntax–pragmatics interface, narrative ability, as well as both receptive and expressive language skills. (4) Conclusions: Three out of four studies provide evidence that bilingual ASD children are not disadvantaged compared to monolingual peers but rather enjoy some benefits, to a certain extent, due to bilingualism. However, the number of the reviewed studies as well as the limitations of the studies themselves render this conclusion tentative. Additionally, the findings set guidelines that speech therapists, educators, psychologists, and doctors in the Greek context need to follow when treating or educating bilingual children with ASD.
The Development of New Primer Sets for the Amplification and Sequencing of the Envelope Gene of All Dengue Virus Serotypes
Authors: Fraenkel Stefania , Nabeshima Takeshi , Xayavong Dalouny , Nguyen Thi Thanh Ngan , Xu Qiang , Kapandji Merveille , Yamao Kano , Balingit Jean Claude , Pandey Basu Dev , Morita Kouichi , Hasebe Futoshi , Ngwe Tun Mya Myat , Takamatsu Yuki
Published: May 2024

Dengue virus (DENV) poses a significant threat to global health, infecting approximately 390 million people annually. This virus comprises four serotypes capable of causing severe disease. Genetic analyses are crucial for understanding the epidemiology, evolution, and spread of DENV. Although previous studies have focused on the envelope protein-coding (E) gene, only a few primers can efficiently detect and amplify the viral genes from multiple endemic countries simultaneously. In this study, we designed degenerate primer pairs for each DENV serotype to amplify and sequence the entire E gene, using globally representative sequences for each serotype. These primers were validated using DENV isolates from various Asian countries and demonstrated broad-spectrum detection capabilities and high-quality sequences. The primers provide effective tools for genetic analysis in the regions affected by dengue, aiding strain identification and epidemiological studies during outbreaks.
Effect of Bifidobacterium bifidum Supplementation in Newborns Born from Cesarean Section on Atopy, Respiratory Tract Infections, and Dyspeptic Syndromes: A Multicenter, Randomized, and Controlled Clinical Trial
Authors: Bellomo Anna Rita , Rotondi Giulia , Rago Prudenza , Bloise Silvia , Di Ruzza Luigi , Zingoni Annamaria , Di Valerio Susanna , Valzano Eliana , Di Pierro Francesco , Cazzaniga Massimiliano , Bertuccioli Alexander , Guasti Luigina , Zerbinati Nicola , Lubrano Riccardo
Published: May 2024

Cesarean section is considered a possible trigger of atopy and gut dysbiosis in newborns. Bifidobacteria, and specifically B. bifidum, are thought to play a central role in reducing the risk of atopy and in favoring gut eubiosis in children. Nonetheless, no trial has ever prospectively investigated the role played by this single bacterial species in preventing atopic manifestations in children born by cesarean section, and all the results published so far refer to mixtures of probiotics. We have therefore evaluated the impact of 6 months of supplementation with B. bifidum PRL2010 on the incidence, in the first year of life, of atopy, respiratory tract infections, and dyspeptic syndromes in 164 children born by cesarean (versus 249 untreated controls). The results of our multicenter, randomized, and controlled trial have shown that the probiotic supplementation significantly reduced the incidence of atopic dermatitis, upper and lower respiratory tract infections, and signs and symptoms of dyspeptic syndromes. Concerning the gut microbiota, B. bifidum supplementation significantly increased α-biodiversity and the relative values of the phyla Bacteroidota and Actinomycetota, of the genus Bacteroides, Bifidobacterium and of the species B. bifidum and reduced the relative content of Escherichia/Shigella and Haemophilus. A 6-month supplementation with B. bifidum in children born by cesarean section reduces the risk of gut dysbiosis and has a positive clinical impact that remains observable in the following 6 months of follow-up.
Screening the Protective Agents Able to Improve the Survival of Lactic Acid Bacteria Strains Subjected to Spray Drying Using Several Key Enzymes Responsible for Carbohydrate Utilization
Authors: Liu Jing , Xie Shanshan , Xu Mengfan , Jiang Xiaoying , Wang Qian , Zhao Hongfei , Zhang Bolin
Published: May 2024

The aim of this study was to identify the most effective protectants for enhancing the viability of specific lactic acid bacteria (LAB) strains (Lactobacillus delbrueckii subsp. bulgaricus CICC 6097, Lactiplantibacillus plantarum CICC 21839, Lactobacillus acidophilus NCFM) by assessing their enzymatic activity when exposed to spray drying (inlet/outlet temperature: 135 °C/90 °C). Firstly, it was found that the live cell counts of the selected LAB cells from the 10% (w/v) recovered skim milk (RSM) group remained above 107 CFU/g after spray drying. Among all the three groups (1% w/v RSM group, 10% w/v RSM group, and control group), the two enzymes pyruvate kinase (PK) and lactate dehydrogenase (LDH) were more sensitive to spray drying than hexokinase (HK) and β-galactosidase (β-GAL). Next, transcriptome data of Lb. acidophilus NCFM showed that 10% (w/v) RSM improved the down-regulated expressions of genes encoding PK (pyk) and LDH (ldh) after spray drying compared to 1% (w/v) RSM. Finally, four composite protectants were created, each consisting of 10% (w/v) RSM plus a different additive—sodium glutamate (CP-A group), sucrose (CP-B group), trehalose (CP-C group), or a combination of sodium glutamate, sucrose, and trehalose (CP-D group)—to encapsulate Lb. acidophilus NCFM. It was observed that the viable counts of strain NCFM (8.56 log CFU/g) and enzymatic activity of PK and LDH in the CP-D group were best preserved compared to the other three groups. Therefore, our study suggested that measuring the LDH and PK activity could be used as a promising tool to screen the effective spray-dried protective agent for LAB cells.