bluuebunny/crossref_metadata_2025 huggingface dataset:
A Meta-Analysis of Cervical Laminoplasty Techniques: Are Mini-Plates Superior?
Authors: Humadi Ali , Chao Tat , Dawood Sulaf , Tacey Mark , Barmare Arshad , Freeman Brian
Published: May 2017

Study Design:

Meta-analysis and systematic review of literature.

Objective:

In the late 1990s, spinal surgeons experimented by using maxillofacial fixation plates as an alternative to sutures, anchors, and local spinous process autografts to provide a more rigid and lasting fixation for laminoplasty. This eventually led to the advent of laminoplasty mini-plates, which are currently used. The objective is to compare laminoplasty techniques with plate and without plate with regard to functional outcome results.

Methods:

Qualitative and quantitative analyses were performed to evaluate the currently available studies in an attempt to justify the use of a plate in laminoplasty.

Results:

The principal finding of this study was that there was no statistically significant difference in clinical outcome between the 2 different techniques of laminoplasty.

Conclusion:

There is not enough evidence in the literature to support one technique over the other, and hence, there is no evidence to support change in practice (using or not using the plate in laminoplasty). A randomized controlled trial will give a better comparison between the 2 groups.
Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins
Authors: Quadros Rolen M. , Miura Hiromi , Harms Donald W. , Akatsuka Hisako , Sato Takehito , Aida Tomomi , Redder Ronald , Richardson Guy P. , Inagaki Yutaka , Sakai Daisuke , Buckley Shannon M. , Seshacharyulu Parthasarathy , Batra Surinder K. , Behlke Mark A. , Zeiner Sarah A. , Jacobi Ashley M. , Izu Yayoi , Thoreson Wallace B. , Urness Lisa D. , Mansour Suzanne L. , Ohtsuka Masato , Gurumurthy Channabasavaiah B.
Published: May 2017

Background

Conditional knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional activators are key for many genetic studies and comprise over 90% of mouse models created. Conditional knockout mice are generated using labor-intensive methods of homologous recombination in embryonic stem cells and are available for only ~25% of all mouse genes. Transgenic mice generated by random genomic insertion approaches pose problems of unreliable expression, and thus there is a need for targeted-insertion models. Although CRISPR-based strategies were reported to create conditional and targeted-insertion alleles via one-step delivery of targeting components directly to zygotes, these strategies are quite inefficient.

Results

Here we describe Easi-CRISPR (Efficient additions with ssDNA inserts-CRISPR), a targeting strategy in which long single-stranded DNA donors are injected with pre-assembled crRNA + tracrRNA + Cas9 ribonucleoprotein (ctRNP) complexes into mouse zygotes. We show for over a dozen loci that Easi-CRISPR generates correctly targeted conditional and insertion alleles in 8.5–100% of the resulting live offspring.

Conclusions

Easi-CRISPR solves the major problem of animal genome engineering, namely the inefficiency of targeted DNA cassette insertion. The approach is robust, succeeding for all tested loci. It is versatile, generating both conditional and targeted insertion alleles. Finally, it is highly efficient, as treating an average of only 50 zygotes is sufficient to produce a correctly targeted allele in up to 100% of live offspring. Thus, Easi-CRISPR offers a comprehensive means of building large-scale Cre-LoxP animal resources.
Fault damage zone characterization in tight-oil sandstones of the Upper Triassic Yanchang Formation in the southwest Ordos Basin, China: Integrating cores, image logs, and conventional logs
Authors: Lyu Wenya , Zeng Lianbo , Liao Zonghu , Ji Yuanyuan , Lyu Peng , Dong Shaoqun
Published: May 2017

Fault damage zones around faults have a significant influence on fluid flow in tight-oil sandstones because they commonly act as localized conduits. Faults are developed in the tight-oil sandstones of the Upper Triassic Yanchang Formation in the southwest Ordos Basin, China. We integrate cores, image logs, and conventional logs from vertical wells to characterize subsurface fault damage zones in the tight-oil sandstones of the Upper Triassic Yanchang Formation in the southwest Ordos Basin, China. The results indicate that fault damage zones are intensively fractured or intensely broken in the cores. These fault damage zones present borehole collapse and widen sinusoidal curves in the image logs. The fractures in fault damage zones are predominant high dip angles. The fracture intensity decays with the increasing orthogonal distance from the faults within a fault damage zone. In fault damage zones, acoustic log (AC) values and compensated neutron log (CNL) values increase; density log (DEN) values decrease, dual induction log (ILD and ILM) and laterolog 8 (LL8) values decrease, the caliper log (CAL) presents borehole enlargement, and comprehensive fracture index log (CFI) values are greater than 0.43 and average 0.78. To identify fault damage zones by conventional logs in vertical wells, it is critical to distinguish fault damage zones from the background fractured zones. The ILM, CNL, ILD, LL8, and AC logs would be more useful than DEN logs for the distinction between background fractured zones and fault damage zones. The responses of fault damage zones in conventional logs are more intensive than those of background fractured zones, and the heights of fault damage zones are much greater than those of background fractured zones, which can be used for the distinction between fault damage zones and background fractured zones.
COUP-TFI mitotically regulates production and migration of dentate granule cells and modulates hippocampal CXCR4 expression
Authors: Parisot Joséphine , Flore Gemma , Bertacchi Michele , Studer Michèle
Published: May 2017

Development of the dentate gyrus (DG), the primary gateway for hippocampal inputs, spans embryonic and postnatal stages and involves complex morphogenetic events. We have previously identified the nuclear receptor COUP-TFI as a novel transcriptional regulator in the postnatal organization and function of the hippocampus. Here, we dissect its role in DG morphogenesis by inactivating it either in granule cell progenitors or in granule neurons. Loss of COUP-TFI function in progenitors leads to decreased granule cell proliferative activity, precocious differentiation and increased apoptosis, resulting in a severe DG growth defect in adult mice. COUP-TFI-deficient cells express high levels of the chemokine receptor CXCR4 and migrate abnormally, forming heterotopic clusters of differentiated granule cells along their paths. Conversely, high COUP-TFI expression levels downregulate CXCR4 expression, whereas increased CXCR4 expression in wild-type hippocampal cells affect cell migration. Finally, loss of COUP-TFI in postmitotic cells leads only to minor and transient abnormalities, and normal CXCR4 expression. Together, our results indicate that COUP-TFI is required predominantly in DG progenitors by modulating expression of the CXCR4 receptor during granule cell neurogenesis and migration.
An interview with Eric Wieschaus
Authors: Maartens Aidan
Published: May 2017

Eric Wieschaus is a HHMI Investigator, and the Squibb Professor in Molecular Biology at Princeton University and the Lewis-Sigler Institute for Integrative Genomics. In 1995, he was awarded the Nobel Prize jointly with Edward Lewis and Christiane Nüsslein-Volhard for discoveries about the genetic control of Drosophila embryogenesis. We caught up with Eric at the joint meeting of the German and Japanese Societies of Developmental Biologists held in Kiel in March 2017, and discussed his career, his thoughts on the field and the impact the Nobel award had on his life.
Oxidative stress affects sperm performance and ejaculate redox status in subordinate House Sparrows
Authors: Rojas Mora Alfonso , Firth Alexandra , Blareau Sophie , Vallat Armelle , Helfenstein Fabrice
Published: May 2017

Oxidative stress (OS) is the result of random cellular damage caused by reactive oxygen species that leads to cell death, ageing, or illness. Most physiological processes can result in OS, which in turn has been identified as a major cause of infertility. In promiscuous species, the fertilizing ability of the ejaculate partly determines the male reproductive success. When dominance determines access to fertile females, theory predicts that lower ranking males should increase resource investment into enhancing ejaculate quality. We hypothesized that subordinate males should thus prioritize antioxidant protection of their ejaculates to protect them from OS. We put this hypothesis to the test, by chronically dosing wild House Sparrows with diquat (∼1mg/kg), an herbicide that increases pro-oxidant generation. We found that, although they increased their antioxidant levels in the ejaculate, diquat-treated males produced sperm with reduced velocity. Importantly, and contrary to our hypothesis, males at the bottom of the hierarchy suffered the largest reduction in sperm velocity. We suggest that resource access hinders individuals' ability to cope with environmental hazards. Our results point at OS as a likely physiological mechanism mediating ejaculate quality, while individual ability to access resources may play a role in constraining the extent to which such resources can be allocated into the ejaculate.
Comparison of FDG PET metabolic tumour volume versus ADC histogram: prognostic value of tumour treatment response and survival in patients with locally advanced uterine cervical cancer
Authors: Ueno Yoshiko , Lisbona Robert , Tamada Tsutomu , Alaref Amer , Sugimura Kazuro , Reinhold Caroline
Published: May 2017

Objective:

To evaluate the prognostic utility of volume-based parameters of fluorine-18 fludeoxyglucose positron emission tomography (18F-FDG PET) and apparent diffusion coefficient (ADC) histogram analysis for tumour response to therapy and event-free survival (EFS) in patients with uterine cervical cancer receiving chemoradiotherapy.

Methods:

The study included 21 patients diagnosed with locally advanced uterine cervical cancer who underwent pre-treatment MRI and 18F-FDG PET and were treated with concurrent chemoradiotherapy. 18F-FDG parameters: maximum and mean standardized uptake value; metabolic tumour volume (MTV); total lesion glycolysis (TLG); ADC parameters: maximum, mean and minimum values; percentile ADC values (10–90%); skewness and kurtosis of ADC were measured and compared between the responder and non-responder groups using a Wilcoxon rank-sum test. The Cox regression analysis and Kaplan–Meier survival curves were performed for EFS analysis.

Results:

MTV and TLG of the primary tumour were significantly higher in the non-responder group than in the responder group (p = 0.04 and p = 0.01). Applying Cox regression multivariate analysis, MTV [hazard ratio (HR), 4.725; p = 0.036], TLG (HR, 4.725; p = 0.036) and 10-percentile ADC (HR, 5.207; p = 0.048) showed a statistically significant association with EFS. With the optimal cut-off value, the EFS rates above the cut-off value for MTV and TLG were significantly lower than that below the cut-off value (p = 0.002 and p = 0.002).

Conclusion:

Pre-treatment volume-based quantitative parameters of 18F-FDG PET may have better potential than ADC histogram for predicting treatment response and EFS in patients with locally advanced cervical cancer.

Advances in knowledge:

In this study, pre-treatment volume-based quantitative parameters of 18F-FDG PET had better potential than ADC histogram for predicting treatment response and survival in patients with locally advanced cervical cancer.
Delayed Small Bowel Perforation with Findings of Severe Ischemia Following Blunt Abdominal Trauma
Authors: Evrimler Sehnaz , Okumuser Irfan , Delibas Deniz
Published: May 2017

Background: Isolated small bowel perforation following blunt abdominal trauma (BAT) is an uncommon situation with high morbidity and mortality rates, and delayed small bowel perforation is even rarer. The pathophysiology of this condition is not clear in all cases. To the best of our knowledge, this is the first case report of delayed small bowel perforation following BAT with extensive portomesenteric vein gas.

Case Report: A 33-year-old male patient was admitted to the emergency department after a car accident. His initial abdominal CT showed no signs of posstraumatic injury. However, follow-up CT, performed after deterioration in his general condition, showed jejunal dilatation, intestinal intramural gas, portomesenteric vein gas, extensive intraperitoneal gas and intraabdominal free fluid. CT findings and emergent laparotomy findings were both compatible with small bowel ischemia-necrosis and perforation.

Conclusions: Delayed small bowel perforation following BAT is thought to occur secondary to mesenteric hematoma formation or mesenteric tear complications. Our patient did not have any mesenteric injury or hematoma on initial abdominal CT. We are not aware of any other case report of delayed small bowel perforation following BAT without signs of intraabdominal injury on initial imaging and extensive portomesenteric vein gas on follow-up imaging. Ischemic bowel necrosis was the main cause of portomesenteric vein gas in our case. Posttraumatic patients should be kept under medical observation and abdominal CT should be preferred for imaging in case of a deterioration in the general condition and laboratory findings or appearance of new abdominal complaints.
ogttMetrics: Data structures and algorithms for oral glucose tolerance tests
Authors: Stubbs Benjamin J. , Frankston Keith , Ramos Marcel , Laranjo Nancy , Sacks Frank M. , Carey Vincent J.
Published: May 2017

We describe an open source software package, ogttMetrics, to compute diverse measures of glucose metabolism derived from oral glucose tolerance tests (OGTTs). Tools are provided to organize, visualize and compare OGTT data from large cohorts. Numerical difficulties in estimation of parameters of the Bergman minimal model are described, and in one large clinical trial, the simpler closed form index of Matsuda is observed to lead to similar rankings of individuals with respect to insulin sensitivity, and similar inferences concerning effects of modifications to carbohydrate content and glycemic index of experimental diets.
Development of the marketing of pesonnel: tribute to managerial fashion or economic need?
Authors: Бушуева
Published: May 2017

Application personnel marketing in the modern companies can help to find coordination between market conditions, interests of the organization and opportunities, and also desires of employees. With respect thereto urgent is a problem of development and implementation in management practice of the marketing program of personnel. In article approaches of researchers in the area personnel marketing are considered, the conclusion is drawn on a marketing role in case of the solution of questions of personnel management which consists in the choice of cost-efficient and socially justified personnel management methods. The model of system of marketing of personnel is also in detail provided, system elements personnel marketing, and also the main tools and these activities are opened. In article results of an empirical research of system of marketing of personnel are given in 10 large retail chain stores of the city of Novosibirsk. The conclusion is drawn on feasibility of development and implementation of the comprehensive program of marketing of personnel. The main effects of implementation of the Marketing program of personnel are given in short-term and long-term prospects.
How to Develop Technological Entrepreneurship in Russia
Authors: Жданкин  , Жданкин Николай
Published: May 2017

In article questions of the problem resolution of a technological entrepreneurship in Russia are considered. It is shown that the problem very urgent and is the cornerstone of innovative development of our country. By means of innovative approaches analysis of a problem is made and its main reasons are established. Generation of the ideas showed the main directions of the problem resolution in which the leading role belongs to development of small and medium business, development of the effective strategy of development for the country, increase in science funding, competition development, fight against corruption, promotion of the ideas in media, to creation of system of mentors and so forth.
The Effectiveness of Economic Security Regions of the Russian Federation
Authors: Дадалко  , Dadalko Vasiliy , Соловкина  , Solovkina E.
Published: May 2017

The article seeks to substantiate the urgency of developing new directions in improving the economic security of the Russian Federation regions, the aim is to form and choosing the direction of increasing the economic efficiency of the security regions. The main objectives are to identify the main problems and threats to economic security and development of the regions in the directions of increasing the economic efficiency of the safety recommendations in the regions. We used methods: observation and collection of factors; historical and logical; analysis, synthesis and others. The result of the study is the formation of and the selected areas to increase the economic efficiency of the security areas, proposed measures for improving the economic security of the concept of regions.
Optimal Approximation for Submodular and Supermodular Optimization with Bounded Curvature
Authors: Sviridenko Maxim , Vondrák Jan , Ward Justin
Published: May 2017

We design new approximation algorithms for the problems of optimizing submodular and supermodular functions subject to a single matroid constraint. Specifically, we consider the case in which we wish to maximize a monotone increasing submodular function or minimize a monotone decreasing supermodular function with a bounded total curvature c. Intuitively, the parameter c represents how nonlinear a function f is: when c = 0, f is linear, while for c = 1, f may be an arbitrary monotone increasing submodular function. For the case of submodular maximization with total curvature c, we obtain a (1 − c/e)-approximation—the first improvement over the greedy algorithm of of Conforti and Cornuéjols from 1984, which holds for a cardinality constraint, as well as a recent analogous result for an arbitrary matroid constraint.

Our approach is based on modifications of the continuous greedy algorithm and nonoblivious local search, and allows us to approximately maximize the sum of a nonnegative, monotone increasing submodular function and a (possibly negative) linear function. We show how to reduce both submodular maximization and supermodular minimization to this general problem when the objective function has bounded total curvature. We prove that the approximation results we obtain are the best possible in the value oracle model, even in the case of a cardinality constraint.

We define an extension of the notion of curvature to general monotone set functions and show a (1 − c)-approximation for maximization and a 1/(1 − c)-approximation for minimization cases. Finally, we give two concrete applications of our results in the settings of maximum entropy sampling, and the column-subset selection problem.
Graph Orientations and Linear Extensions
Authors: Iriarte Benjamin
Published: May 2017

Given an underlying undirected simple graph, we consider the set of its acyclic orientations. Each of these orientations induces a partial order on the vertices of our graph and, therefore, we can count the number of linear extensions of these posets. We want to know which choice of orientation maximizes the number of linear extensions of the corresponding poset, and this problem will be solved essentially for comparability graphs and odd cycles, presenting several proofs. The corresponding enumeration problem for arbitrary simple graphs will be studied, including the case of random graphs; this will culminate in (1) new bounds for the volume of the stable set polytope and (2) strong concentration results for our enumerative statistic and for the graph entropy, which hold true a.s. for random graphs. We will then argue that our problem springs up naturally in the theory of graphical arrangements and graphical zonotopes.
The emerging role of executive headteachers
Authors: Wespieser Karen
Published: May 2017

What is an executive headteacher? Karen Wespieser looks at the role and skills of the growing number of executive headteachers and outlines the strategic purpose of this emerging role
Innovations in AfL
Authors: Aubrey-Smith Fiona
Published: May 2017

The outstanding St John Baptist Primary School in Lewisham has some innovative approaches to Assessment for Learning. Fiona Aubrey-Smith met headteacher John Goodey to find out more
Conducting a TA audit
Authors: Sobel Daniel
Published: May 2017

Are your school's teaching assistants effective? Or perhaps we should ask: do you train, deploy and manage them effectively. Daniel Sobel says that poor use of TAs can harm student outcomes. He explains how to carry out an effective audit of your TA provision
What are the early signs of abuse or neglect?
Authors: O'Connell Suzanne
Published: May 2017

Most schools are clear about those signs of abuse and neglect that should lead to a referral. But what about the first warning signs that something needs further investigation? NICE has released draft guidance to help schools and other services know what these are. Suzanne O'Connell takes a look
Compulsory at last – relationships education
Authors: O'Connell Suzanne
Published: May 2017

The campaign has been long and difficult, but at last those determined to see the introduction of statutory relationships and sex education have been rewarded. What can primary headteachers expect now as the discussions and consultations set in? Suzanne O'Connell reports
Spot the ladybird!
Authors: Garner Lynne
Published: May 2017

Help children to design their own ladybirds made out of paper plates. As they decorate each one with spots, ask them how many they have decided to use, whether the number is odd or even and which has the most.
Catching raindrops
Authors: White Hilary
Published: May 2017

Investigate the nature of rain through language, artwork and scientific experiment. Turn the results of these activities into a display that will provide a reminder and talking point about enjoying rainy days.
Can you catch it?
Authors: Clarke Jenni
Published: May 2017

Continue a theme of ‘All about me’ – encouraging children to express themselves through physical actions. Provide imaginative cues, to help them extend their games and make connections.
Life under canvas
Authors: Williams Brenda
Published: May 2017

Children find the idea of camping exciting and will have experienced it some form – from holidaying in tents or camper vans, to picnicking for a day. Use Brenda Williams' poem to explore the experience.
Teaching perseverance
Authors: Thornton Stephanie
Published: May 2017

After tackling wisdom and optimism, Dr Stephanie Thornton now considers how we might ‘teach’ and encourage our students to develop skills of perseverance
A major step forward?
Authors: Trafford Bernard
Published: May 2017

The recent Select Committee report on mental health is welcome, but has one glaring omission and one worrying inclusion, says Dr Bernard Trafford
A culture of belief
Authors: Denton Phil
Published: May 2017

The ROAR programme seeks to raise students' expectations and aspirations for university study. Phil Denton explains more about how it works and how you can set up something similar in your school
A checklist for examinations
Authors: Chima Jugjit
Published: May 2017

The summer 2017 exams series officially starts on Monday, May 15. As schools make their last-minute preparations Jugjit Chima offers a final checklist to help
Exams during Ramadan
Authors: Cole Anna
Published: May 2017

Ramadan will fall during this year's summer examinations. Anna Cole discusses how to support Muslim students who are taking exams while also observing Ramadan
Projective partitions of vector spaces
Authors: Javaheri Mohammad
Published: May 2017

Given infinite-dimensional real vector spaces $V,W$ with $|W| \leq |V|$, it is shown that there exists a collection of subspaces of $V$ that are isomorphic to $W$, mutually intersect only at 0, and altogether cover $V$.
Pressões (sócio)linguísticas na determinação do acento enfático: análise de alguns fenômenos variáveis
Authors: Gonçalves Carlos Alexandre
Published: May 2017

Analise do fenômeno da ênfase prosódica, tomando como base seu efeito em fenômenos de variação/mudança linguística. Descrição da ênfase como grupo de fator relevante em pesquisas labovianas sobre processo de assimilação -ndo/-no. os fenômenos de aférese e prótese em processos de intensificação da língua.
A CONSTRUÇÃO DO PASSADO: ROMANCEIRO DA INCONFIDÊNCIA, DE CECÍLIA MEIRELES
Authors: Paranhos Maria da Conceição
Published: May 2017

Este breve estudo trata da literatura, em especial, da poesia, em sua potencialidade de desmistificar a história oficial, e o modo como O Romanceiro da Inconfidência, de Cecília Miereles, realiza esse percurso revelador.
O QUE VAMOS DESENHAR? CARACTERIZAÇÃO DAS MODALIDADES DO DESENHO NO SISTEMA EDUCACIONAL BRASILEIRO
Authors: De Almeida Campos Ana Rita Sulz
Published: May 2017

O presente trabalho traz uma breve análise da trajetória da matéria Desenho na história educacional brasileira através da caracterização de suas modalidades no ensino oficial, ressaltando as interferências políticas e os aspecto legais que regulamentam esse ensino.
Effectiveness of combined laser-puncture and conventional wound care to accelerate diabetic foot ulcer healing
Authors: Srilestari Adiningsih , Nareswari Irma , Simadibrata Christina , Tarigan Tri J.E.
Published: May 2017

Background: Impaired wound healing is a common complication of diabetes. It has complex pathophysiologic mechanisms and often necessitates amputation. Our study aimed to evaluate the effectiveness of combined laser-puncture and conventional wound care in the treatment of diabetic foot ulcers.Methods: This was a double-blind controlled randomized clinical trial on 36 patients, conducted at the Metabolic Endocrine Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, between May and August 2015. Stimulation by laser-puncture (the treatment group) or sham stimulation (the control group) were performed on top of the standard wound care. Laser-puncture or sham were done on several acupuncture points i.e. LI4 Hegu, ST36 Zusanli, SP6 Sanyinjiao and KI3 Taixi bilaterally, combined with irradiation on the ulcers itself twice a week for four weeks. The mean reduction in ulcer sizes (week 2–1, week 3–1, week 4–1) were measured every week and compared between the two groups and analyzed by Mann-Whitney test.Results: The initial median ulcer size were 4.75 (0.10–9.94) cm2 and 2.33 (0.90–9.88) cm2 in laser-puncture and sham groups, respectively (p=0.027). The median reduction of ulcer size at week 2–1 was -1.079 (-3.25 to -0.09) vs -0.36 (-0.81 to -1.47) cm2, (p=0.000); at week 3–1 was -1.70 (-3.15 to -0.01) vs -0.36 (-0.80 to -0.28) cm2, (p=0.000); and at week 4–1 was -1.22 (-2.72 to 0.00) vs -0.38 (-0.74 to -0.57) cm2, (p=0.012).Conclusion: Combined laser-puncture and conventional wound care treatment are effective in accelerating the healing of diabetic foot ulcer.
Clinical characteristics of acute respiratory distress syndrome survived patients at a tertiary hospital in Jakarta
Authors: Amin Zulkifli , Rahmawati Fitriana N. , Mamudi Chrispian O. , Amanda Astrid P.
Published: May 2017

Background: While a good deal of research on characteristic the different characteristics between surviving and dying patient with ARDS has been conducted globally, such research is scarce in developing countries. This study aimed to obtain clinical profile of ARDS survivors during hospitalization.Methods: This was a prospective, observational study conducted at a tertiary hospital in Jakarta from October 2015 to April 2016. Primary data was collected from ARDS patients based on Berlin Definition admitted to emergency room, ICU, HCU, ICCU, and all other wards. The patients were followed until they discharged. We only included survivors on the analysis. Descriptive analysis was done using SPSS 21.0.Results: A total of 43 patients were survived during study period. The majority were below 65 years of age (69.8%) and were male (53.5%). ARDS was mainly mild in severity (62.8%) and early onset (55.8%). Sepsis was the most common causes of ARDS (97.7%). Most of the patients had comorbidities (74.4%). Majority of the patients had APACHE II score <20 (77.3%) with mean 15.6±4.8. The mean of albumin was 2.9±0.6 and the median of procalcitonin was 3 (0.1-252.3.Conclusion: The clinical profile of ARDS survivors in our study were mostly similar with other studies conducted in developed and other developing countries.
The suppression of manganese superoxide dismutase decreased the survival of human glioblastoma multiforme T98G cells
Authors: Hardiany Novi S. , Sadikin Mohamad , Siregar Nurjati , Wanandi Septelia I.
Published: May 2017

Background: Glioblastoma multiforme (GBM) is a primary malignant brain tumor which has poor prognosis. High incidence of oxidative stress-based therapy resistance could be related to the high antioxidant status of GBM cells. Our previous study has reported that manganese superoxide dismutase (MnSOD) antioxidant expression was significantly higher in high grade glioma than in low grade. The aim of this study was to analyze the impact of MnSOD suppression toward GBM cell survival.Methods: This study is an experimental study using human glioblastoma multiforme T98G cell line. Suppression of MnSOD expression was performed using in vitro transfection MnSOD-siRNA. The MnSOD expression was analyzed by measuring the mRNA using real time RT-PCR, protein using ELISA technique, and specific activity of enzyme using inhibition of xantine oxidase. Concentration of reactive oxygen species (ROS) intracellular was determined by measuring superoxide radical and hydrogen peroxide. Cell survival was analyzed by measuring viability, proliferation, and cell apoptosis.Results: In vitro transfection of MnSOD-siRNA suppressed the mRNA, protein, and specific activity of MnSOD. This treatment significantly increased the concentration of superoxide radical; however, it did not influence the concentration of hydrogen peroxide. Moreover, viability MnSOD-suppressing cell significantly decreased, accompanied by increase of cell apoptosis without affecting cell proliferation.Conclusion: The suppression of MnSOD expression leads to decrease glioblastoma multiforme cell survival, which was associated to the increase of cell apoptotic.
Association between obesity and behavioral/emotional disorders in primary school-aged children: a cross-sectional study
Authors: Aditya Clarissa J. , Sekartini Rini
Published: May 2017

Background: Obesity in children can increase the risks of various chronic diseases. Mental disorders associated with obesity in children include: depression, anxiety, low self-esteem, hyperkinetic disorders, and increased aggressiveness. This relationship is estimated due to vulnerable genetic expressions in obese individuals. This study aimed to find the association between obesity and behavioral/emotional disorder in primary school-aged children.Methods: This cross-sectional study was conducted on 384 children at Menteng 1 Elementary School, Jakarta from July to September 2015. The study was conducted to find the association between the children’s nutritional status and behavioral/emotional disorders screened by the 17-item Pediatric Symptom Checklist (PSC-17). Chi square analysis was applied in this study.Results: The prevalence of obese children at Menteng 1 Elementary School, Jakarta reached 23.2%, which is higher than Jakarta’s prevalence (14%). 8.7% of the subjects were obese and 13.6% of them were having behavioral/emotional disorders. 20.0% of the obese subjects had behavioral/emotional disorders. The prevalence was higher for internalizing sub-scale, which was consistent with other studies. Association between obesity and behavioral/emotional disorders was significant for externalizing sub-scale (p=0.036). Externalizing problems caused by obesity might be affected by the social stigma of their peer group. However, obesity in children did not have a statistically significant relationship in internalization sub-scale, attention, and PSC-17 total score (p>0.05). No significant associations towards those sub-scales were thought to be influenced by other factors, playing a role in causing mental disorders in children.Conclusion: In general, obesity was not associated with behavioral and emotional disorders in children, but obesity was related to externalizing behavioral/emotional disorders.
The voice of Indonesian health scientists
Authors: Hamid Agus Rizal A.H.
Published: May 2017

[no abstract available]
CONCEPÇÕES DE CRIATIVIDADE NO CONTEXTO EDUCACIONAL: UM NOVO OLHAR FORMATIVO
Authors: Morais Maria José da Silva , Pinho Maria José de
Published: May 2017

A criatividade na formação continuada de professores na perspectiva educativa como um bem social pautada no (re)pensar, (re)planejar e (re)significar tanto do aprender quanto ensinar é urgente na contemporaneidade. Nesse aspecto, o presente artigo busca compreender o conceito de criatividade e sua relevância na formação continuada de professores do ensino fundamental. Esta discussão é fruto de um recorte da fundamentação teórica de dissertação de Mestrado em Educação da Universidade Federal do Tocantins (UFT) que se apoiou na abordagem qualitativa de caráter exploratório. A pesquisa apontou a necessidade de uma formação que prima pelas bases teóricas da criatividade, na constante busca da ressignificação e da aprendizagem, bem como o fazer mais aberto e dinâmico. Esses aspectos sinalizam que a criatividade carece ser assumida como um valor educativo e um bem social para haver professores e estudantes criativos atentando para as questões sociais, políticas, econômicas, educacionais e planetárias. Ou seja, cidadãos que estão preocupados consigo mesmo e com a melhoria de toda a sociedade. Portanto, é indispensável formar professores com consciência e atitudes ampliadas para transformar situações adversas em ações criativas. E isto implica admitir uma prática crítica e construtiva de novos conhecimentos para o fazer compartilhado de novos significados para dimensão formativa na atualidade.
REFLEXÕES SOBRE A FORMAÇÃO DOCENTE: SEUS DETERMINANTES E SUAS IMPLICAÇÕES IDENTITÁRIAS
Authors: Fernandes Carla Natalina da Silva , Vicentine Fernanda Bergamini , Silva Natália Michelato , Carvalho Tassia Aparecida Martins , Mundin Tainy Benassi , Souza Maria Conceição Bernado de Mello , Goes Fernanda Santos Nogueira , Silva Marta Angélica Iossi
Published: May 2017

Este artigo teve como objetivo elaborar uma reflexão teórico-vivencial a partir da disciplina Docência Universitária em Saúde: Formação da Identidade Profissional, oferecida pelo Programa de Pós-graduação em Enfermagem da Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo, no segundo semestre de 2013. O trabalho do docente é um constante aprendizado, pois a identidade profissional é permeada pelo próprio fazer cotidiano, sendo essa construída, mantida ou modificada na relação estreita que os sujeitos têm com a realidade. Discutir a formação docente implica em uma atividade complexa, assim como a própria profissão, envolve tensões e dilemas que constituem as necessidades e a identidade de seus atores: os professores. Assim, a constituição identitária docente se dá pela percepção de si, dos outros e com os outros, essa pluralidade experimentada na existência também é refletida no pluralismo em que se pratica a docência.
Sumario
Authors: - -
Published: May 2017

Sumario
REFLEXIONES TEÓRICAS O METODOLÓGICAS: ¿Qué modelos de enseñanza se pueden encontrar en las clases de biología en la escuela secundaria?
Authors: Zapata Rocío De los Milagros
Published: May 2017

El siguiente trabajo tiene como objetivo poner en discusión el desarrollo de las clases de biología en la escuela secundaria, poniendo la mirada en la práctica docente a la hora de organizar y desenvolver las clases. Para esto, tomaré como referencia los enfoques o modelos de enseñanza de la ciencia, a partir de realizar una indagación de los diversos autores y su correspondiente descripción. Como resultado de la exploración realizada se releva en los especialistas un acuerdo en encontrar clases que se correlacionan con el enfoque tradicional, o mezclas de los modelos que generan un hibrido en la práctica; junto con motivos explícitos o implícitos en cada docente que llevan a la utilización intencional o no del modelo. Esta problematización de la práctica, es preliminar a un trabajo de investigación que incluirá elestudio de casos concretos de docentes en biología y sus clases, a realizar posteriormente.
EXPERIENCIAS PEDAGÓGICAS: Educación alimentaria nutricional: desafío universidad- escuela- comunidad
Authors: Ortigoza Liliana D. V. , Sedlacek Natalia M. , Pacheco Jimena N. , Dezar Gimena V. A.
Published: May 2017

La Educación Alimentaria Nutricional (EAN) se utilizó en esta experiencia como herramienta estratégica a fin de fortalecer vínculos entre universidad y comunidad. La EAN se propone como catalizador en seguridad y soberanía alimentaria, nutrición comunitaria e intervenciones en salud. Desde el interés conjunto de la escuela secundaria pública No 0684, la Facultad deBioquímica y Ciencias Biológicas (FBCB), Universidad Nacional del Litoral (UNL) y el Ministerio de Desarrollo Social de Santa Fe, se desarrollaron acciones interdisciplinarias participando docentes del ciclo inicial y superior de la carrera de Licenciatura en Nutrición (LN) FBCB-UNL, estudiantes avanzados de LN, directivos, docentes y alumnos de la escuela, interesados en su propia salud y el bienestar de la comunidad. El objetivo del presente artículo es dara conocer las distintas etapas que se llevaron a cabo para la concreción y desarrollo de un Proyecto de Extensión de Interés Social con eje en EAN, como así también las valoraciones de los futuros egresados en relación al proyecto. Se generaron redes tendientes a promover la EAN por parte de alumnos, Instituciones escolares, Universidad, hacia la comunidad. El desarrollo del proyecto mencionado dio lugar a experiencias educativas contextualizadas, permitiendo así integrar la docencia con la extensión.
INVESTIGACIONES EDUCATIVAS 87: El discurso científico sobre el papel: la importancia de la redacción de tareas
Authors: Lorenzo Gabriela M.
Published: May 2017

La formación docente de profesores universitarios en actividad debe ser pensada de manera singular, vinculada a sus propias prácticas disciplinares. Esto implica un desafío a la hora de presentar propuestas que resulten estimulantes y novedosas para ellos y que a su vez, les permitan recuperar su experiencia como estudiantes. En este trabajo presentamos una actividad diseñada en el marco de la asignatura Didáctica y Epistemología de las Ciencias de la Saluden la Carrera Docente de la Facultad de Farmacia y Bioquímica de la Universidad de Buenos Aires y que ha sido implementada en numerosos dispositivos de formación y capacitación docente. Presentaremos inicialmente los fundamentos teóricos que fundamentaron su diseño, relativos al lenguaje científico y a las competencias comunicativas de los profesores y los alumnos, para a continuación discutir sobre la actividad y mostrar algunos resultados de suimplementación que ponen contundentemente en evidencia la importancia de la redacción de las consignas en la calidad de los aprendizajes que se promueven en los estudiantes.
RESÚMENES Y COMENTARIOS DE TESIS: Enseñanza de la anatomía orientada al desarrollo de competencias en la carrera de Bioingeniería
Authors: Castañeda Liliana A.
Published: May 2017

Esta reseña presenta algunos aspectos abordados durante la realización de mi trabajo de tesis de maestría, fundamentalmente de la metodología y principales resultados y conclusiones.El objetivo de dicho trabajo fue investigar el valor de una intervención didáctica orientada al estímulo de competencias académicas específicas para el aprendizaje de la Anatomía e Histología Humanas, en la carrera de Bioingeniería. Su desarrollo hizo hincapié en entender las competencias como capacidades complejas, que integran saberes teóricos, procedimentales y del contexto, y que permiten adquirir y aplicar distintos saberes en el ámbito académico. A tal efecto, fueron combinadas metodologías cuantitativa y cualitativa, seleccionándose competencias académicas específicas para el aprendizaje de la Anatomía e Histología Humanas, cuyo desarrollo es necesario incentivar en los estudiantes para su disponibilidad permanente.Se establecieron para cada una de esas competencias indicadores y niveles de logro, y en consonancia se diseñaron y aplicaron las estrategias didácticas orientadas a su desarrollo.El análisis de la información reveló que: (a) los estudiantes tuvieron una opinión favorable sobre la experiencia pues facilitó el aprendizaje comprensivo; (b) los aprendizajes logrados estuvieron disponibles y fueron posibles de aplicar a nuevas situaciones, y (c) la enseñanza orientada al desarrollo de competencias contribuyó positivamente a mejorar el rendimientoacadémico de los estudiantes.
RESÚMENES Y COMENTARIOS DE TESIS: La Inteligencia Emocional de docentes universitarios y su implicancia en estudiantes de ciencias experimentales
Authors: Bocco María Inés
Published: May 2017

El trabajo que se presenta forma parte de una Tesis de la Maestría en Didáctica de las Ciencias Experimentales de la Facultad de Bioquímica y Ciencias Biológicas (FBCB) de la Universidad Nacional del Litoral (UNL).Consiste en el estudio de la relación que existe entre Capacidades de la Inteligencia Emocional (CIE) en docentes universitarios y el desempeño académico de estudiantes del ciclo básico de las carreras de Bioquímica y Licenciatura en Biotecnología de la UNL.El termino Inteligencia Emocional (IE) surge de Salovey y Mayer (1990) y se refiere a la capacidad de reconocer nuestros propios sentimientos y de los demás, y de manejar bien las emociones. Además sostienen que la inteligencia interpersonal es un área de la IE, y la definen como la capacidad para comprender a los demás, entender cómo operan y cómo se debe trabajar cooperativamente.La empatía, que se desprende de la inteligencia interpersonal, es la habilidad que se posee para entender lo que están sintiendo otras personas y ubicarse en situaciones desde su perspectiva. Esta habilidad social favorece el liderazgo, y puede ser usada para persuadir, dirigir, negociar y resolver situaciones que promuevan el trabajo en equipo.
RESÚMENES Y COMENTARIOS DE TESIS: Actitudes hacia la química de los estudiantes de biología: una reflexión sobre su evolución desde química general e inorgánica a química biológica
Authors: Reyes Maria S. , Porro S.
Published: May 2017

En el presente artículo se reflexiona sobre la importancia de la dimensión afectiva en el proceso de enseñanza-aprendizaje de las ciencias experimentales en general y de la química en particular. Se describen las actitudes hacia la química de los estudiantes de las carreras de Licenciatura en Biodiversidad y Profesorado en Biología de la Universidad Nacional del Litoral, analizando las mismas en tres cursos de química: Química General e Inorgánica, Química Orgánica y Química Biológica. Poniéndose de manifiesto que en aquellas asignaturas donde los estudiantes se sienten más motivados con los contenidos de la cátedra o bien los consideran más afines y cercanos con su formación profesional, sus actitudes evolucionan favorablemente observándose también una mejora en el rendimiento académico.
A bivariate Pareto type I models
Authors: Abd Elaal Mervat , Alzahrani Hind
Published: May 2017

In this paper two new bivariate Pareto Type I distributions are introduced. The first distribution is based on copula, and the second distribution is based on mixture of and copula. Maximum likelihood and Bayesian estimations are used to estimate the parameters of the proposed distribution. A Monte Carlo Simulation study is carried out to study the behavior of the proposed distributions. A real data set is analyzed to illustrate the performance and flexibility of the proposed distributions.
Student Off-Task Electronic Multitasking Predictors: Scale Development and Validation
Authors: Qian Yuxia , Li Li
Published: May 2017

In an attempt to better understand factors contributing to students’ off-task electronic multitasking behavior in class, the research included two studies that developed a scale of students’ off-task electronic multitasking predictors (the SOTEMP scale), and explored relationships between the scale and various classroom communication processes and outcomes. The first study inductively developed initial typologies for the SOTEMP scale, refined the scale item pool, and explored the dimensions of the scale. Subsequently, the second study validated the scale through a confirmatory factor analysis and by assessing different concurrently existing communication processes as well as students’ perceived learning outcomes. Four factors were found: Lack of Class Relating, Technology Dependence, Class Easiness, and Overwhelmed feeling. Reliability and validity were established for the scale. Results indicated the SOTEMP scale was positively related to students’ cognitive absorption, and negatively related to students’ perception of their affective learning. However, the SOTEMP scale was not related to students’ perceived cognitive learning. Limitations and implications for future research are discussed.
Looping and Attachment in Early Childhood Education: How Applications of Epigenetics Demand a Change
Authors: Nitecki Elena
Published: May 2017

Increasing focus on the quality of child care and pre-K is calling attention to the circumstances of child care and impact on the child’s social and emotional health, specifically in terms of attachment. The early childhood profession recognizes that consistency in caregiving is essential for the child’s attachment. Looping, the practice of keeping a group of children with the same teacher for more than year, has the potential to provide that consistency that is critical for attachment. The field of epigenetics and its compelling findings in regard to attachment demand a second look at looping and how it can be implemented to maintain attachment, which is critical to the child’s physical, cognitive, and emotional health now and in the future. This case study conducted at a preschool that practices looping examines the benefits and challenges of looping through the lens of applied epigenetics.
A Theoretically Grounded Framework for Integrating the Scholarship of Teaching and Learning
Authors: Walls Jill K.
Published: May 2017

SoTL scholars have written about the importance and utility of teaching from a guiding theoretical framework. In this paper, ecological theory and specifically Bronfenbrenner’s bioecological model, is examined as a potential framework for synthesizing SoTL research findings to inform teaching and learning scholarship at the college level. A general overview of the bioecological model of human development and its application to the SoTL literature are provided. The benefit of adopting an ecologically-based framework to better understand and exploit the interdisciplinary nature of SoTL is discussed.
“They Look at Themselves and Say: “Well, Okay…””: The Contribution of Video to Professional Identity Development
Authors: Nortvig Anne-Mette
Published: May 2017

This paper focuses on the development of professional identity by the use of video technology. On the basis of empirical material from a professional bachelor’s e-learning programme, it is argued that the use of video can contribute to reflection of professional identity through its opportunities for visual reification of the professional “Me”: while acting in profession-like settings, the students experience their professional actions from an inside “I”-perspective, but while watching themselves on the video recording of it later on, they can see, reflect and evaluate their professional “Me” from an outside perspective in the role of the professional other.