bluuebunny/crossref_metadata_2025 huggingface dataset:
miR-22 exerts anti-alzheimic effects via the regulation of apoptosis of hippocampal neurons
Authors: Wang Yu , Zhao Lan , Kan Bohong , Shi Huiyan , Han Jingxian
Published: February 2019

To investigate the expression of miR-22 in the hippocampus of amyloid Î² (1-42)-induced alzheimic rats, and to assess the underlying mechanism. A total of 60 male Sprague Dawley rats weighing between 274.65 and 293.97 g (mean weight = 284.31 ± 9.66 g) and aged 12 to 14 weeks were randomly assigned to three groups: control group (n = 20), Alzheimer's disease group (AD group; n = 20) and AD + miR-22 mimic group (ADMM group; n = 22). Rat AD model was established by injecting a solution of AÎ²1-42 into the hippocampal CA1 regions. After 24 h, rats in the ADMM group also received intraventricular injection of miR-22 mimic continuously for 28 days. The escape latency of rats, neuronal damage in the hippocampus, synaptic structure, brain-derived neurotrophic factor (BDNF), and the expressions of apoptosis-related proteins were assessed or determined, as appropriate. The expression of miR-22 in hippocampus of the AD group was significantly lower than that in the control group (p < 0.05). However, after 28 days of intraventricular injection of miR-22 mimic into AD rats, the expression was significantly increased, relative to control (p < 0.05). The escape latency of AD rats was significantly prolonged, and the number of platform sites significantly reduced when compared to the control group (p < 0.05). However, the escape latency was significantly shortened and the number of platform sites significantly increased in the ADMM group, relative to the control and AD groups. Results of transmission electron microscopy showed that the expression of miR-22 significantly reversed the degradation of synaptic structures in the hippocampus of AD rats as evidenced by recovery of abnormal synaptic cleft width and the length of synaptic active zones (p < 0.05). Results of Nissl staining revealed significant proliferation of gliacyte and loss of Nissl bodies. After miR-22 injection, the number of gliacytes in the hippocampus of AD rats was significantly reduced, while the number of Nissl bodies was significantly increased (p < 0.05). The expressions of BDNF in CA1 and CA2/3 regions of AD rats were significantly lower than those in the control group, and BDNF in the hippocampus of AD rats was significantly increased after 28 days of continuous injection of miR-22 (p < 0.05). The positive expression of Tunnel in the ADMM group (22.67 ± 2.96 %) was significantly higher than that in the AD group (4.49 ± 1.23 %), but significantly lower than that of control (39.51 ± 3.66 %) (p < 0.05). After 28 days of intraventricular injection of miR-22 mimic into AD rats, the expression of Bax protein was significantly down-regulated, while bcl-2 protein was significantly up-regulated (p < 0.05). The expression of miR-22 in the hippocampus of patients with AD inhibits neuronal apoptosis, thereby improving learning and memory dysfunction.
MicroRNA 494 increases chemosensitivity to doxorubicin in gastric cancer cells by targeting phosphodiesterases 4D
Authors: Peng Qiu-Ping , Du De-Bing , Ming Quan , Hu Fang , Wu Zhen-Bao , Qiu Shaoqin
Published: February 2019

Acquired drug resistance is one of the main limitations in pharmacological therapy of malignancies including gastric cancer. MicroRNAs (miRNAs) are a class of small noncoding RNAs that suppress their targets by binding to the 3'UTR region of genes. In this study, we explored investigate the target gene of miR-494 and its roles in chemoresistance of gastric cancer. We found that miR-494 was significantly down-regulated in gastric cancer cells lines compared to the normal gastric epithelial cell line. Exogenous overexpression of miR-494 increased the chemosensitivity of gastric cancer cells to doxorubicin. Moreover, miR-494 expression was reduced in a doxorubicin-resistant gastric cancer cells (AGS/dox) compared with the parental cells. MTT assay showed that AGS/dox cells exhibited an elevated viability compared with the parental cells. Enforced expression of miR-494 inhibited AGS/dox cell viability and colony formation ability. In addition, we demonstrated that elevated expression of miR-494 inhibited the mRNA and protein expression of phosphodiesterases 4D (PDE4D) in gastric cancer cell. Luciferase assay showed that miR-494 directly targeted the 3'UTR region of PDE4D. Furthermore, restoration of PDE4D recovered the chemoresistance in miR-494-overexpressed gastric cancer cells. Taken together, this study demonstrated that miR-494 enhanced doxorubicin sensitivity via regulation of PDE4D expression, suggesting a novel therapeutic strategy for anti-chemoresistance in gastric cancer.
Studying the C1772T polymorphism of Hif-1Î± and TGF-Î²3 IVS5+104 A/G polymorphism in children with congenital non-syndromic neural tube defects and their mothers
Authors: Yildirim ć°brahim Halil , Koçak Nadir
Published: February 2019

Prevalence of neural tube defect (NTD) has reduced after folic acid intake. However; which mechanisms are effective in NTD are not known exactly. In this study; due to the possible effects on hypoxic pathway and embryonic development, particularly on extracellular matrix components, Hif-1Î± Pro582Ser and TGF-Î²3 IVS5+104 A/G SfaN1 polymorphisms were studied by PCR-RFLP method both on children with NTDs and mothers. Statistical differences were seen for Hif-1Î± and TGF-Î²3 IVS5+104 A/G SfaN1 polymorphisms in children with NTDs but no difference was seen in mothers. Both genes are effective on many pathways and our results suggest that regulation of extracellular matrix components of children during fetal life is important in neural tube defects formation. The results of this study show that Hif-1Î± Pro582Ser and TGF-Î²3 IVS5+104 A/G SfaN1 polymorphisms may play a role in NTDs.
Analysis of codon usage bias in the VP1 gene of the human norovirus GII.2 genotype
Authors: Wang Haoning , Cui Guanglin , Wang Xiaolong , Zhang Minghai , Tan Jimin , Li Xingguang
Published: February 2019

To investigate the codon usage patterns of all available VP1 gene sequences of the GII.2 genotype, to determine the factors that affect these patterns, and to provide comprehensive details of the characteristics and evolution of the gene. Complete 519 sequences of VP1 gene of the HuNoV GII.2 genotype with known sampling dates and geographic locations from 1971 - 2017 were retrieved from the GenBank nucleotide database of the National Center for Biotechnology Information (NCBI) and analyzed. The percentage composition of T, C, A, and G nucleotides were 24.80 ± 0.30, 26.61 ± 0.31, 25.84 ± 0.13, and 22.75 ± 0.17 %, respectively, with C and A relatively more abundant than T and G, and C the most abundant (p < 0.0001). The values of T3s (34.10 ± 0.90 %) and C3s (33.54 ± 0.90 %) were significantly higher than those of A3s (29.98 ± 0.43 %) and G3s (24.13 ± 0.51 %) (p < 0.0001). While T3s was highest among the four nucleotides, G3s was the lowest. Among the 18 most frequently employed synonymous codons, six optional codons ended with T, five ended with C, five ended with A and two ended with G. Codons ending with T were the most frequently used. The ENC ranged from 51.90 to 54.25 (mean = 52.38 ± 0.43) among the 519 VP1 gene sequences. There were significant correlations between ENC and C % and G % (p < 0.01). Codons containing CpG (1 and 2 or 2 and 3 codon positions) showed the lowest frequencies, while 30, 29, and 2 codons were above, below and on the mean line, respectively. The first four principal components accounted for 69.11 % of the total variation, with the first, second, third, and fourth principal axes contributing 37.90, 14.83, 9.61, and 6.77 %, respectively. The strains were not clustered by country of isolation or year of sampling. Gravy were significantly correlated with T3s, C3s, G3s, GC3s, and ENC (p < 0.01). Mutation pressure and natural selection contributed to the codon usage bias of the VP1 gene of the HuNoV GII.2 genotype. There was a correlation between GC12s and GC3s (R2 = 0.032; p < 0.0001). The relative neutrality was 3.20 %, while natural selection was 96.80 %. The VP1 gene exhibits low codon usage bias which is affected primarily by natural selection, followed by mutation pressure and translational selection.
Neuronal survival of DRG neurons after neurite transection in vitro promotes by nerve growth factor and brain derived neurotrophic factor
Authors: Kaval Oğuz Elif
Published: February 2019

Neurotrophic factors are growth factors that promote neuronal survival, regulate synaptic function and neurotransmitter release, and promote the plasticity and growth of axons in the peripheral and central nervous systems. This study focused on the roles of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the survival of adult dorsal root ganglion (DRG) neurons following axotomy. To investigate this, we cultured adult mouse DRG neurons and administered NGF or BDNF to the culture medium at different doses before transection. After determining the optimal doses of NGF and BDNF, these factors were then applied in combination. Axotomy was performed using a precise laser beam and neuronal death was visualized through cell observer microscopy system, by adding propidium iodide to the culture medium. The results demonstrate that the optimal doses of NGF and BDNF for neuronal survival are 150 ng/mL and 50 ng/mL, respectively. The highest level of neuronal survival was observed in the cells treated with a combination of NGF and BDNF. In conclusion, NGF and BDNF have a positive effect, both individually and in combination, on the survival of DRG neurons following neurite transection.
Expression of cardiac inwardly rectifying potassium channels in pentylenetetrazole kindling model of epilepsy in rats
Authors: Akyüz Enes , Mega Tiber Pınar , Beker Merve , Akbaş Fahri
Published: February 2019

Clinical and experimental studies show that epilepsy affects cardiac function; however, the underlying molecular mechanism has not been fully elucidated. Inwardly-rectifying potassium (Kir) channels transport K+ ions into excitable cells such as neurons and cardiomyocytes; they control the cell excitability by acting towards the repolarization phase of cardiac action potential. Kir channel expression has been previously shown to vary in epileptic brains, at the same time seizures are known to affect the autonomic nervous system. Kir channel expression in cardiac tissue is a possible mechanism for the explanation of cardiac pathology in epilepsy. We investigate the expression of Kir channels in epileptic cardiac tissue by using pentylenetetrazole (PTZ)-kindling model in rats. Our molecular analyses showed significant decrease in cardiac Kir channel mRNA and protein expression of PTZ-kindled rats. Interestingly, both Kir2.x, which directs IK1 flux in ventricular tissue and Kir3.x, which is responsible for IKACh in the atria, were observed to decrease significantly. Kir channel expression also differs between females and males. This is the first study to our knowledge in epileptic cardiac tissue showing the expression of Kir channels. Our results show that Kir channels may play a role in cardiac pathology associated with epilepsy.
Rozważania pedagogiczne Seneki a ideał stoickiego władcy w traktacie „De cłementia”
Authors: Blaszczyk Ilona
Published: February 2019

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Szlakami przeszłości i czasów współczesnych, red. K. Puchowski i J. Zerko, Wydawnictwo Uniwersytetu Gdańskiego, Gdańsk 1996, ss. 387
Authors: Jakubiak Krzysztof
Published: February 2019

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Pedagogika ogólna. Tradycja — teraźniejszość — nowe wyzwania (materiały pokonferencyjne), red. Teresa Hejnicka-Bezwińska, Wydawnictwo Uczelniane WSP, Bydgoszcz 1995, ss. 329
Authors: Leppert Roman
Published: February 2019

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Historia wychowania. Przewodnik, praca zbiorowa pod red. Joanny Kuryło-Omelianiuk, Ewy Romanowskiej, Teresy Zaniewskiej, Wydawnictwo Uniwersyteckie Trans Humana, Białystok 1996, ss. 160
Authors: Gulczyńska Justyna
Published: February 2019

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Stanisław Obirek SJ, Wizja państwa w nauczaniu jezuitów polskich w latach 1564-1668, Kraków 1995, ss. 7
Authors: D.Ż.-S. .
Published: February 2019

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Od studenta do magistra. Jak długo trwały studia polskich dominikanów w XV wieku?
Authors: Kaczmarek Krzysztof
Published: February 2019

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Dorota Żołądź-Strzełczyk, Peregrinatio académica. Studia młodzieży polskiej z Korony i Litwy na akademiach i uniwersytetach niemieckich w XVI i pierwszej połowie XVII wieku, Wydawnictwo Naukowe Uniwersytetu im. Adama Mickiewicza, Poznań 1996, s. 241
Authors: Kosman Marceli
Published: February 2019

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Zenon Jasiński, Kazimierz Rędziński, Polscy uchodźcy i polskie szkoły w Czechach i na Morawach w czasie I wojny światowej, Instytut Nauk Pedagogicznych Uniwersytetu Opolskiego, Opole 1985, ss. 104
Authors: Litwin Andrzej
Published: February 2019

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Leonard Grochowski, Studia z dziejów polskiej szkoły i pedagogiki lat międzywojennych, Warszawa 1996, ss. 187
Authors: Lech Danuta
Published: February 2019

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Historyczne źródła wybranych ofert edukacyjnych w Polsce współczesnej. Materiały z konferencji naukowej nt. „Teoretyczne i praktyczne oferty edukacyjne we współczesnej pedagogice i ich źródła historyczne”, D. Drynda, D. Ekiert-Grabowska, W. Łusz- czuk, Wydawnictwo Uniwersytetu Śląskiego, Katowice 1996, ss. 154
Authors: Jakubiak Krzysztof
Published: February 2019

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Wychowanie córek władców polskich
Authors: Żolądź-Strzelczyk Dorota
Published: February 2019

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Bibliografia historii wychowania (druki zwarte wydane w Polsce w 1. 1995-1996)
Authors: . .
Published: February 2019

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Konferencja naukowa: Historyk nauk medycznych wobec inspiracji badawczych. Teoria i tradycja
Authors: Szymczak Marek
Published: February 2019

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Edyta Głowacka-Sobiech, Twórcy polskiego skautingu - Olga i Andrzej Małkowscy, Wydawnictwo Poznańskie, Poznań 2003, ss. 283
Authors: Wałąga Agnieszka
Published: February 2019

Edyta Głowacka-Sobiech, Twórcy polskiego skautingu - Olga i Andrzej Małkowscy, Wydawnictwo Poznańskie, Poznań 2003, ss. 283
Works about John Dewey 1886-1995, completed and edited by Barbara Levine, Southern Illinois University Press, Carbondale & Edwardsville 1996, ss. 526
Authors: Brejnak Hanna
Published: February 2019

Works about John Dewey 1886-1995, completed and edited by Barbara Levine, Southern Illinois University Press, Carbondale & Edwardsville 1996, ss. 526
Teresa Podgórska, Stowarzyszenie Patriotyczno-Religijne Eleusis w latach 1902-1914, Wydawnictwo Katolickiego Uniwersytetu Lubelskiego, Lublin 1999, ss. 157
Authors: Głowacka-Sobiech Edyta
Published: February 2019

Teresa Podgórska, Stowarzyszenie Patriotyczno-Religijne Eleusis w latach 1902-1914, Wydawnictwo Katolickiego Uniwersytetu Lubelskiego, Lublin 1999, ss. 157
Kazimierz Szmyd, Twórcy nauk o wychowaniu w środowisku akademickim Lwowa (1860-1939), Wydawnictwo Uniwersytetu Rzeszowskiego, Rzeszów 2003, ss. 530
Authors: Głowacka-Sobiech Edyta
Published: February 2019

Kazimierz Szmyd, Twórcy nauk o wychowaniu w środowisku akademickim Lwowa (1860-1939), Wydawnictwo Uniwersytetu Rzeszowskiego, Rzeszów 2003, ss. 530
Iwona Wendreńska, Dydaktyka ogólna jako przedmiot kształcenia nauczycieli w Drugiej Rzeczypospolitej (1918 -1939), Wydawnictwo Uniwersytetu Śląskiego, Katowice 2003, ss. 171
Authors: Rodek Violetta
Published: February 2019

Iwona Wendreńska, Dydaktyka ogólna jako przedmiot kształcenia nauczycieli w Drugiej Rzeczypospolitej (1918 -1939), Wydawnictwo Uniwersytetu Śląskiego, Katowice 2003, ss. 171
Dorota Żołądź-Strzelczyk, Wiesław Jamrożek, Studia z dziejów edukacji kobiet na ziemiach polskich, Agencja Wydawniczo-Poligraficzna „Bajt”, Poznań 2001, ss. 152
Authors: Karłowska Grażyna
Published: February 2019

Dorota Żołądź-Strzelczyk, Wiesław Jamrożek, Studia z dziejów edukacji kobiet na ziemiach polskich, Agencja Wydawniczo-Poligraficzna „Bajt”, Poznań 2001, ss. 152
Źródła do dziejów wychowania w rodzinie polskiej w XIX i początkach XX wieku, wybór i opracowanie A. Denisiuk, K. Jakubiak, Wydawnictwo Akademii Bydgoskiej, Bydgoszcz 2001, ss. 290
Authors: Nawrot Monika
Published: February 2019

Źródła do dziejów wychowania w rodzinie polskiej w XIX i początkach XX wieku, wybór i opracowanie A. Denisiuk, K. Jakubiak, Wydawnictwo Akademii Bydgoskiej, Bydgoszcz 2001, ss. 290
Bibliografia historii wychowania, szkolnictwa i myśli pedagogicznej w Polsce za rok 2001 (z uzupełnieniami za rok 2000)
Authors: Gruca Anna
Published: February 2019

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Ogólnopolska konferencja naukowa „Filozofia wychowania”. 28-29 kwietnia 2003 r.
Authors: Świtka Małgorzata
Published: February 2019

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Konferencja „Nauczanie domowe dzieci na ziemiach polskich w XIX i na początku XX wieku. Zapatrywania teoretyczne i praktyka” . Pieczyska, 18-19 września 2003 r.
Authors: Karłowska Grażyna
Published: February 2019

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Czesław Kupisiewcz, Z dziejów teorii i praktyki wychowania, Oficyna Wydawnicza „Impuls”, Warszawa 2012, ss. 322
Authors: Iwanicki Juliusz
Published: February 2019

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D. Żołądź-Strzelczyk, K. Kabacińska-Łuczak, Codzienność dziecięca opisana słowem i obrazem. Życie dziecka na ziemiach polskich od XVI do XVIII wieku, Wydawnictwo DiG, Warszawa 2012, ss. 192
Authors: Nowicki Michał
Published: February 2019

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A. Fijałkowski, Tradycja i nowatorstwo w Orbis sensualium pictus Jana Amosa Komeńskiego, Wydawnictwa Uniwersytetu Warszawskiego, Warszawa 2012, ss. 410
Authors: Ryś Jan
Published: February 2019

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Iwona Jakimowicz-Ostrowska, Mniejszości narodowe w Gdyni w latach 1944–2005, Gdynia 2008, ss. 309
Authors: Burzyńska-Wentland Lidia
Published: February 2019

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Słownik biograficzny twórców oświaty i kultury XIX i XX wieku Polski południowo-wschodniej, pod red. Andrzeja Meissnera i Kazimierza Szmyda, Wyd. Uniwersytetu Rzeszowskiego, Rzeszów 2011, ss. 494
Authors: Wałęga Agnieszka
Published: February 2019

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Z dziejów polskiej kultury i oświaty od średniowiecza do początków XX wieku, pod red. Krzysztofa Jakubiaka i Tomasza Maliszewskiego, Kraków 2010, ss. 536
Authors: Pudłocki Tomasz
Published: February 2019

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Sprawozdanie z międzynarodowej konferencji „W kręgu rodziny epok dawnych. Rytmy życia – rytmy codzienności. Dzieciństwo”, Kraków, 17–18.10.2012
Authors: Kabacińska-Łuczak Katarzyna
Published: February 2019

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Problemy wychowawcze w szkołach bazyliańskich w drugiej połowie XVIII wieku na przykładzie kolegium w Buczaczu
Authors: Lorens Beata
Published: February 2019

Education problems in Basilian Schools in the latter half of the 18th century, with an example of the College in Buczacz.The literature concerning monastic education in the 18th century omits the subject of educational and teaching activity of Saint Basil the Great Monastery or discusses it very briefly. Not much is known about functioning of those schools in the period before the Commission of National Education was founded. The educational programme and the problems connected with it, which had occurred in Basilian schools were presented on the example of the college in Buczacz, located in the southeastern part of the Republic of Poland, functioning between 1754 and 1784. The educational goals pursued in the college were not different from the ones of other monastic schools. The then educational system mostly promoted the respect for ideological and moral values, considering material values less important. In the educational process, the Basilian Monks put piety first. The misdeeds of the students of the college in Buczacz were punished according to the canon of conduct of the then youth studying in monastic schools. The canon included: getting drunk, forbidden meetings with women, thefts, scuffles with soldiers in magnates’ service and stationed in the town, as well as with Jewish people. In the latter half of the 18th century, great significance was attached to proper conduct of the students of the college and misconducts against morals were the most common reasons for expulsions.
Kształcenie w zakresie grafiki w szkolnictwie artystycznym Krakowa, Lwowa i Wilna w latach międzywojennych
Authors: Boguszewska Anna
Published: February 2019

Training in graphics in the artistic education of Cracow, Lvov and Vilnius during the interwar years (1918–39)The beginnings of art education in Poland are connected with the cities of Cracow, Vilnius and Warsaw in the 18th and 19th centuries. In the interwar period (1918–39), in addition to the most powerful graphics education center in Warsaw, this discipline of art developed intensively in the art schools in Lvov, Cracow and Vilnius. The development of graphics in the Cracow Academy is related to the artistic and educational activities of Józef Pankiewicz. In 1923, the independent Department of Graphic Arts was established, conducted by John Wojnarski in collaboration with Andrzej Jurkiewicz and Jan Rubczak. The next outstanding teachers are Ludwik Gardowski and Konrad Strzednicki. Graphics education in the Municipal School of Art Industry (Miejska Szkoła Przemysłu Artystycznego) in Cracow is headed by Witold Chomicz. Graphics education in Lvov is linked to the activity of such artists as Ludwik Tyrowicz and Maria Rużycka. Ferdynand Ruszczyc, Bonawentura Lenart introduce the study of graphics into the curriculum of the Faculty of Fine Arts at Stefan Batory University in Vilnius. Since 1930, Jerzy Hoppen started the graphics workshop. In the 1930s, the graphic arts established a permanent and significant position in Polish art education.
POLACY UCZĄ SIĘ UKRAIŃSKIEGO. WPŁYW CZYNNIKA TYPOLOGICZNEGO NA PROCESY PRZYSWAJANIA JĘZYKÓW OBCYCH
Authors: Nowacka Dagmara
Published: February 2019

Перша частина статті — це спроба окреслити ситуацію вивчення української мови в Польщі не лише як мови нацменшини, але і як іноземної мови. Поляки охоче вивчають іноземні мови, зокрема й мови своїх сусідів, а отже, українську та російську. Чи близька спорідненість мов допомагає, чи, швидше, заважає ефективно її вивчити? Друга частина статті — аналіз частотних студентських помилок.
ВИЯВ ЕҐОЦЕНТРИЧНОЇ СЕМАНТИЧНОЇ ОПОЗИЦІЇ ‘ТАМ’ — ‘ТУТ’ В УКРАЇНСЬКІЙ МОВІ
Authors: Пилипак Валерія
Published: February 2019

W artykule pokazano i poddano analizie przejawy opozycji semantycznej ‘tam’ — ‘tutaj’ w języku ukraińskim w kontekście głównych antropo- i egocentrycznych podejść do analizy zjawisk językowych. Сelem artykułu jest aktualizacja egocentrycznej treści ‘tam’ na poziomie leksykalnym, gramatycznym, w różnych tekstach w języku ukraińskim.
ФІЛОСОФІЯ ПОЕЗІЙ ВІСЛАВИ ШИМБОРСЬКОЇ ТА ЛІНИ КОСТЕНКО: КОМПАРАТИВНІ АСПЕКТИ
Authors: Дячок Світлана
Published: February 2019

W artykule zbadano realizacje motywów filozoficznych w twórczości polskiej poetki Wisławy Szymborskiej oraz ukraińskiej pisarki Liny Kostenko poprzez zestawienie porównawcze ich twórczego myślenia. Autorka skupia uwagę na analizie w wybranych dziełach poetyckich takich kategorii filozoficznych, jak istnienie, czas, przestrzeń, ruch. To właśnie one za pośrednictwem przeżyć i doświadczeń podmiotu lirycznego pojawiają się w poezji W. Szymborskiej i L. Kostenko. Analizie poddano również motyw przeznaczenia człowieka, sensu życia.
КАТЕГОРІЯ МОВЧАННЯ В НОВЕЛІ МИКОЛИ ХВИЛЬОВОГО Я (РОМАНТИКА)
Authors: Horniatko-Szumiłowicz Anna
Published: February 2019

Artykuł poświęcony jest realizacji kategorii milczenia w noweli Mykoły Chwylowego Ja (Romantyka). Spośród znaków graficznych odzwierciedlających milczenie w analizowanym utworze można wyznaczyć liczne wielokropki, poziome linie przerywane dzielące tekst, fragmentację tekstu jako znak materialny uczucia niedopowiedzenia. Oprócz tego Mykoła Chwylowy po wielokroć wykorzystuje słowa oznaczające ciszę / milczenie, w tym rzeczowniki (”cisza” i ”milczenie”), przymiotniki (”milczący”, ”wyludniony”, ”głuchy”, ”martwy”), przysłówki (”cicho”, ”pusto”, ”milcząco”), czasowniki (”milczeć”, ”szeleścić”) itp. Innym środkiem eksplikacji efektu ciszy w utworze jest apelowanie do obrazów wzrokowych za pomocą powtarzających się w tekście czasowników ”patrzeć”, ”widzieć”, ”spoglądać”, ”wpatrywać się”, ”obserwować”, ”oglądać się” i in. W utworze milczą bohaterowie, miasto, przyroda, potwierdzając niemożność wyrażenia słowami prawdziwych uczuć i, odpowiednio, wymowność milczenia, które zdolne jest wyrazić wszystko.
ПАРАДИГМА ФОЛЬКЛОРНО-ЛІТЕРАТУРНОЇ АРХЕТИПНОСТІ
Authors: Янковська Жанна
Published: February 2019

Celem artykułu jest opracowanie paradygmatu folklorystyczno-literackiej archetypowości oraz określenie jej podłoża teoretycznego. Realizacja owego celu wskazuje na specyficzną metodologię przeprowadzenia analizy utworów (utworu) określonego pisarza czy pewnego okresu rozwoju lieteratury pod względem włączenia w treści utworu literackiego archetypów narodowych, bazujących na obrazach archetypowych. Daje to możliwość gruntownego opracowania zagadnienia “folkloryzmu literatury” oraz reinterpretacji poszczególnych utworów.
CYRYLA STAWROWIECKIEGO OD CZYTANIA TWÓRCZOŚCI PIOTRA SKARGI — NA PRZYKŁADZIE ŻYWOTA ŚW. STEFANA I KAZANIA NA OŚWIĘCENIE ŚWIĄTYNI
Authors: Kuczyńska Marzanna
Published: February 2019

У статті проаналізовано гомілетичні твори Кирила Ставровецького (?–1646), руського теолога, проповідника, агіографа, поета, видавця першого руського теологічного трактату Зерцало богословії, а також збірки повчань Євангеліє учительноє і Перло многоцінноє крізь призму запозичень з проповідей та агіографічних творів польського єзуїта Петра Скарґи. Впливи останнього помітні в багатьох текстах православного проповідника, причому два вище вказані в заголовку твори позначені найбільшою залежністю від першозразків. У пошану пам’яті св. Cтепана Петро Скарґа cтворив дві праці — житіє та проповідь — і обидві Ставровецький використав. Щодо твору На посвячення святині звернувся додатково до проповіді Якуба Вуйка — іншого польського єзуїта. Для письменника характерний творчий підхід, відмова від безрефлексійного засвоєння католицького матеріалу, адаптування з урахуванням догматичних і культурних відмінностей.
ZROZUMIEĆ SIEBIE SAMYCH I INNYCH. LUDZKI WYMIAR HISTORII W KSIĄŻCE ODWAGA I STRACH OLI HNATIUK
Authors: Ursulenko Anna
Published: February 2019

У статті розглянуто питання реконструкції психологічного ландшафту міста Львова часів Другої світової війни, що репрезентовано в книжці Відвага і страх Олі Гнатюк, основу якої становить розповідь про долі львівської інтелігенції під час радянської та німецької окупації. Проаналізовано вибрані аспекти книжки, що утворюють своєрідне “case study” впливу феномена страху на життя окремих людей та спільнот в екстремальних умовах.
КОНЦЕПТ “ВІЙНА” В ІНДИВІДУАЛЬНО-АВТОРСЬКІЙ КАРТИНІ СВІТУ ОКСАНИ ЗАБУЖКО (НА МАТЕРІАЛІ ЗБІРКИ „І ЗНОВ Я ВЛІЗАЮ В ТАНК…”)
Authors: Гоменюк Олена
Published: February 2019

W artykule przedstawiono analizę konceptu “wojna” w autorskim obrazie świata znanej ukraińskiej pisarki, poetki i eseistki Oksany Zabużko. Analizy dokonano na przykładzie zbioru utworów publicystycznych „I znowu włażę do czołgu…”, który został poświęcony wydarzeniom Rewolucji Godności oraz wojnie, toczącej się na Ukrainie od 2014 roku. Scharakteryzowano główne werbalizatory konceptu oraz jego semantykę, która obejmuje przede wszystkim znaczenia autorskie.
ФУНКЦІЙНО-КОМУНІКАТИВНИЙ РІВЕНЬ ЛІНГВОПЕРСОНИ: ЗАКОНОМІРНОСТІ САМОРЕАЛІЗАЦІЇ ЛІНГВОПЕРСОНИ
Authors: Загнітко Анатолій , Загнітко Надія
Published: February 2019

W artykule wyznaczono główne typy personologii lingwistycznej z rozróżnieniem lingwopersonologii ogólnej, kulturowej, kognitywnej, społecznej, lingwopersonologii samorealizacji oraz samoutwierdzenia. Ponadto scharakteryzowano zasady systemowości i kontrastywności jako kluczowe dla opisów lingwopersonologicznych, wyznaczono główne cechy kategorii osobowości, osobowości językowej oraz personalizmu. Scharakteryzowano funkcyjno-komunikacyjny poziom osobowości językowej wraz z określeniem jego głównych cech, wyznaczeniem realizacji typologicznych, jak również poziomy: werbalno-semantyczny, motywacyjny oraz kognitywny.
PERCEPCJA KIJOWA W TWÓRCZOŚCI ALEKSANDRA KUPRINA
Authors: Bortnowski Antoni
Published: February 2019

Олександр Купрін був російським письменником, який на ранньому етапі свого життя потрапив до Києва. Сім років (1892–1899), які він провів у цьому місті, мали потужний вплив на всю його творчість. Образи Києва з'являються не тільки у збірці Київські типи (1896), але також у пізніших творах письменника, зокрема еміграційних. Олександр Купрін був справжнім реалістом, який з великою точністю намагався відобразити специфіку довкілля, завдяки чому на сторінках його творів репрезентована вся різноманітність київського життя к. ХІХ – поч. ХХ століття.
ЮРІЙ ВИННИЧУК ЯК УПОРЯДНИК УКРАЇНСЬКОЇ ЛІТЕРАТУРНОЇ СПАДЩИНИ
Authors: Lis-Markiewicz Przemysław
Published: February 2019

W artykule dokonana została analiza działalności Jurija Wynnyczuka jako autora wyboru tekstów. Podjęto próbę defi nicji antologii jako gatunku literackiego, zwięźle przedstawiono poszczególne antologie i zbiory tekstów pisarza oraz określono jego wkład w rozwój współczesnej literatury ukraińskiej.
“ЯКАСЬ МОЗАЇКА СТРОКАТА І ВІРШІ РІЗНИХ РОЗМІРІВ”: ПОПІЛ ІМПЕРІЙ ЮРІЯ КЛЕНА
Authors: Mnich Roman
Published: February 2019

Artykuł poświęcony został twórczości jednego z najwybitniejszych ukraińskich poetów XX wieku, przedstawiciela “neoklasyków”, Jurija Klena (1891–1947). Przesłanie ideowe poematu Popiół imperiów zinterpretowano w świetle całej twórczości neoklasyka, również jego spuścizny naukowej. Szczególną uwagę zwrócono na fragment wskazanego poematu pt. Pokusa Lucyfera oraz przewodni dla niego obraz nadczłowieka (Übermensch).
Query log compression for workload analytics
Authors: Xie Ting , Chandola Varun , Kennedy Oliver
Published: February 2019

Analyzing database access logs is a key part of performance tuning, intrusion detection, benchmark development, and many other database administration tasks. Unfortunately, it is common for production databases to deal with millions or more queries each day, so these logs must be summarized before they can be used. Designing an appropriate summary encoding requires trading off between conciseness and information content. For example: simple workload sampling may miss rare, but high impact queries. In this paper, we present L
OG
R, a lossy log compression scheme suitable for use in many automated log analytics tools, as well as for human inspection. We formalize and analyze the space/fidelity trade-off in the context of a broader family of "pattern" and "pattern mixture" log encodings to which L
OG
R belongs. We show through a series of experiments that L
OG
R compressed encodings can be created efficiently, come with provable information-theoretic bounds on their accuracy, and outperform state-of-art log summarization strategies.
The maximum trajectory coverage query in spatial databases
Authors: Ali Mohammed Eunus , Eusuf Shadman Saqib , Abdullah Kaysar , Choudhury Farhana M. , Culpepper J. Shane , Sellis Timos
Published: February 2019

With the widespread use of GPS-enabled mobile devices, an unprecedented amount of trajectory data has become available from various sources such as Bikely, GPS-wayPoints, and Uber. The rise of smart transportation services and recent break-throughs in autonomous vehicles increase our reliance on trajectory data in a wide variety of applications. Supporting these services in emerging platforms requires more efficient query processing in trajectory databases. In this paper, we propose two new coverage queries for trajectory databases: (i)
k Best Facility Trajectory Search
(
k
BFT); and (ii)
k Best Coverage Facility Trajectory Search
(
k
BCovFT). We propose a novel index structure, the Trajectory Quadtree (TQ-tree) that utilizes a quadtree to hierarchically organize trajectories into different nodes, and then applies a z-ordering to further organize the trajectories by spatial locality inside each node. This structure is highly effective in pruning the trajectory search space, which is of independent interest. By exploiting the TQ-tree, we develop a divide-and-conquer approach to efficiently process a
k
BFT query. To solve the
k
BCovFT, which is a
non-submodular NP-hard problem,
we propose a greedy approximation. We evaluate our algorithms through an extensive experimental study on several real datasets, and demonstrate that our algorithms outperform baselines by two to three orders of magnitude.
Smurf
Authors: C. Paul Suganthan G. , Ardalan Adel , Doan AnHai , Akella Aditya
Published: February 2019

We argue that more attention should be devoted to developing self-service string matching (SM) solutions, which lay users can easily use. We show that Falcon, a self-service entity matching (EM) solution, can be applied to SM and is more accurate than current self-service SM solutions. However, Falcon often asks lay users to label many string pairs (e.g., 770-1050 in our experiments). This is expensive, can significantly compound labeling mistakes, and takes a long time. We developed Smurf, a self-service SM solution that reduces the labeling effort by 43-76%, yet achieves comparable F
1
accuracy. The key to make Smurf possible is a novel solution to efficiently execute a random forest (that Smurf learns via active learning with the lay user) over two sets of strings. This solution uses RDBMS-style plan optimization to reuse computations across the trees in the forest. As such, Smurf significantly advances self-service SM and raises interesting future directions for self-service EM and scalable random forest execution over structured data.
THE RISE OF ROBOTS! EFFECTS ON EMPLOYMENT AND INCOME
Authors: ÖZCAN Rasim
Published: February 2019

Disruptive technological advances will have profound impacts on the employment landscape over the years to come. As in the past, new technologies will change the way humans live and work. Some occupations will become obsolete, while new occupations will emerge. Consequently, people will be displaced from some occupations, be forced to require new skills so that they can work in new occupations. Although the introduction of new technologies –robotization– has many dimensions, its effects will range from structural unemployment to distribution of labor income. The first question would be what will be the impact of new technologies on labor demand? Given that new technologies expectedly increase productivity, hence income, the second question would be how the raise be distributed between low and high skilled labor. Hence, this study focuses on the effects of robotization on the structural unemployment, its implications on labor demand and its income distribution effects. I review the current situation of robotization, and make recommendations to policy makers and corporate managers to get prepared for accelerating robotization and not only to mitigate its potential adverse effects on employment and income distribution, but also to take this as an opportunity to increase the quality of life for all.
VERİ MADENCİLİĞİNDE SINIFLANDIRMA ALGORİTMALARININ PERFORMANS DEĞERLENDİRMESİ VE R DİLİ İLE BİR UYGULAMA
Authors: ÇINAR Ayşe
Published: February 2019

Sınıflandırma Yöntemi, veri madenciliğinin başlıca yöntemlerinden biri olup, öğrenme algoritmasına dayanır. Büyük ölçekli bir veri içinde gizli kalmış bir örüntüyü keşfetmek amacıyla uygulanır. Veri madenciliği kapsamında, örüntü, bir varlık için dijital ortamda kaydedilmiş; gözlemlenebilir, ölçülebilir ve tekrar edilebilir bir bilgi olarak ifade edilmektedir. Ulaşılmak istenen bilginin elde edilmesi için uygulanan sınıflandırma algoritmaları, içerdiği verinin ortak özelliğine göre veri setinin belirli sınıflara ayrılmasını (ayrıklaştırılmasını) sağlamaktadırlar. Bu işlemin ardından bir sınıflandırma modeli elde edilir. Elde edilen sınıflandırma modeli yeni bir veri seti üzerinde uygulanarak, model ile belirlenmiş olan sınıfların veri seti içindeki benzerlerinin varlığı araştırılır. Söz konusu işlem “örüntü tanıma” olarak isimlendirilmektedir. Bu çalışmada, veri madenciliğinde sınıflandırma süreci ele alınarak, C5.0 ve Gini isimli iki farklı sınıflandırma algoritması ile bir uygulama gerçekleştirilmiştir. Bu amaçla açık kaynak kodlu R dili uygulanarak, her iki sınıflandırma modelinin tahmin değerlerinin doğruluğuyla ilgili performans ölçüm değerleri elde edilmiştir. Ayrıca, en iyi performans ölçüm değerine sahip bir model ele alınarak, sonuçları değerlendirilmiştir
On two applications of nanomechanics to future technology
Authors: Louizos Alexandros , Aifantis Elias C.
Published: February 2019

In this short communication, we introduce two applications of nanomechanics, based on standard molecular dynamics simulations, to problems of critical importance to future technology. One of these problems is concerned with “nanoenergy,” in particular, hydrogen storage in fullerenes. The other problem is concerned with “nanomedicine,” in particular, the effect of sodium chloride on collagen molecules. An extension of these preliminary results and their use in developing continuum nanomechanics models is underway, and it will be the theme of two separate future publications.
Gestational nutrition 1: alterations to gestational nutrition can increase indicators of fertility in sheep
Authors: Smith Peter , Stanton Jo-Ann L , Quirke Laurel , Juengel Jennifer L
Published: February 2019

The aim of this study was to examine the relationships between gestational nutrition, fetal ovarian development and offspring fertility in female sheep and to highlight the potential mechanisms underlying these relationships. Adult sheep (n = 79) were fed either a maintenance or 0.6 of maintenance plane of nutrition for the first 55 days of gestation and thereafter fed ad libitum. Fetuses were collected for analysis at days 55 and 75 of gestation. Female offspring were monitored from birth until 19 months of age. Effects of restricted nutrition were observed on maternal plasma concentrations of progesterone, creatinine, albumin and Ca2+ at day 55 and creatinine at day 75. Concentrations of metabolic factors and steroid hormones in day 75 fetal plasma were not affected by the restricted maternal plane of nutrition. At day 55 of gestation, fetal ovarian germ cell development was not affected by maternal plane of nutrition. At day 75 of gestation ovaries from fetuses whose dams were exposed to restricted nutrition contained more germ cells but had lower germ cell proliferation rates than controls. For female offspring at 8 months of age, the dams gestational plane of nutrition did not affect the onset of puberty, ovulation rate (OR) and antral follicle counts (AFC). At 19 months of age, ewes from dams exposed to the restricted plane of gestational nutrition had higher OR, AFC and progesterone concentrations while concentrations of FSH were lower. In conclusion, while effects on fertility per se are yet to be determined, a reduced maternal plane of gestational nutrition can improve indicators of fertility in female offspring.
Factors Associated With Unrestrained Young Passengers in Motor Vehicle Crashes
Authors: Roehler Douglas R. , Elliott Michael R. , Quinlan Kyran P. , Zonfrillo Mark R.
Published: February 2019

BACKGROUND AND OBJECTIVE:

Unrestrained child passengers are at significant risk of crash-related injury. Previous researchers using nationally representative crash data from 1992 to 1993 found an association between driver and passenger safety-belt use. Our objective in this study is to investigate factors associated with young, unrestrained passengers in fatal and nonfatal motor vehicle crashes using updated national crash data.

METHODS:

We analyzed 2011–2015 Fatality Analysis Reporting System and National Automotive Sampling System data and included vehicles with a young passenger (≤19 years old) in a crash. Driver and passenger characteristics were compared by using bivariate analyses separately for fatal and nonfatal crashes. Logistic regression analyses were performed on a combined data set to predict passenger restraint use.

RESULTS:

In unadjusted bivariate models, unrestrained drivers had a higher probability of having an unrestrained passenger across all passenger age groups for both fatal and nonfatal crashes. In multivariate logistic regression models that included both fatal and nonfatal crashes and were adjusted for several driver and passenger characteristics, unrestrained drivers had a higher risk of having an unrestrained young passenger across all age groups.

CONCLUSIONS:

In both fatal and nonfatal crashes, a driver being unrestrained is a strong predictor of the child passenger also being unrestrained. Policy and regulation to better ensure that drivers are properly restrained (eg, expanding primary seat-belt laws to all states) may serve as effective means for increasing rates of proper child-occupant–restraint use.
Comparison of the Use of Conventional and Digital Visualization Technologies in Environmental Design Education / Usporedba uporabe tradicionalnih i digitalnih tehnika vizualizacije u obrazovanju za dizajn za okoliš
Authors: Tarakci Eren Emine , Düzenli Tugba , Yılmaz Serap
Published: February 2019

AbstractThe rapid advances in computer technology rendered the use of the new technologies in professional disciplines such as visual arts, design, architecture and planning, where visualization is utilized prominently i.e. is a requirement. However, applications such as using conventional design tools and graphical presentation techniques, sketching, drawing plans, sections, perspectives on paper and creating models are still used in landscape architecture, architecture, interior architecture or in departments that rely on planning. Digital technologies, on the other hand, are used as supplementary tools. The aim of the present article was to determine the methods utilized predominantly in different stages of environmental design studio in landscape architecture education and the advantages and disadvantages of the utilized conventional and digital presentation techniques, and to compare the developing visualization software. In this context, the level of satisfaction of the students with these methods were determined. The study was conducted with students in the Landscape Architecture Department attending Karadeniz Technical University (KTU). The study findings demonstrated that the satisfaction levels of architecture students with digital technologies were higher when compared to conventional methods due to the facilities and superior qualities provided by the digital technologies.Key words: conventional and digital visualization; environmental design studio; technology; satisfaction level.---SažetakBrzi napredak računalne tehnologije omogućio je uporabu novih tehnologija u profesionalnim disciplinama kao što su likovna umjetnost, dizajn, arhitektura i prostorno planiranje u kojima se dominantno oslanjamo na vizualizaciju. Preciznije, vizualizacija je potreba. Međutim, primjena tradicionalnih alata za dizajn i za tehnike grafičkog prikazivanja, skiciranja, iscrtavanja planova, profili, perspektive na papiru i izrada modela još uvijek se koriste u arhitekturi okoliša, arhitekturi, unutarnjoj arhitekturi ili u granama koje ovise o planiranju. Digitalne tehnologije, s druge strane, koriste se kao dodatni alati. Cilj ovoga rada je odrediti koje se metode dominantno koriste u različitim fazama u studiju dizajna za okoliš u obrazovanju za arhitekturu okoliša te usporediti razvijene programe za vizualizaciju. U tom kontekstu određena je razina zadovoljstva studenata s tim metodama. Istraživanje je provedeno sa studentima s Odjela za arhitekturu okoliša pri Sveučilištu Karadeniz Technical University (KTU). Rezultati istraživanja pokazali su da su razine zadovoljstva studenata arhitekture s digitalnim tehnologijama više u usporedbi s tradicionalnim metodama zbog uvjeta i superiorne kvalitete koju nude digitalne tehnologije.Ključne riječi: tradicionalna i digitalna vizualizacija; studio dizajna za okoliš; tehnologija, razina zadovoljstva.
Media and Information Literacy - the Basis for Applying Digital Technologies in Teaching from the Discourse of Educational Needs of Teachers / Medijska i informacijska pismenost – osnova za primjenu digitalnih tehnologija u nastavi iz diskursa obrazovnih
Authors: Novković Cvetković Biljana , Stošić Lazar , Belousova Alla
Published: February 2019

AbstractThe expansion of new digital media and the development of information technology give even bigger importance to media and information literacy, which is recognized as one of the key skills in the educational system almost everywhere in the world. The concept of media and information literacy in this paper is considered from the pedagogical aspect, i.e., the aspect of the educational needs of the teacher in learning and applying digital technologies in the teaching process.The aim of this paper is to determine the level of the teachers’ interest in the application of certain digital technologies in the teaching process on the one hand, and to determine similarities and differences in their needs for learning and applying digital technologies in the teaching process according to their gender and work experience, on the other hand.The conclusion is that teachers who participated in the survey showed high interest in learning and applying digital technologies in the teaching process. The use of the computer and the Internet appeared to be the biggest need teachers have. Key words: digital technologies; educational needs; information literacy; media literacy; teaching process.---SažetakEkspanzija novih digitalnih medija i napredak informacijske tehnologije uvjetuju sve veću važnost medijske i informacijske pismenosti, koja se priznaje kao jedna od ključnih vještina u obrazovnom sustavu gotovo u cijelom svijetu. Koncept medijske i informacijske pismenosti u ovom se radu promatra s pedagoškog aspekta, odnosno s aspekta obrazovnih potreba nastavnika za poznavanjem i primjenom digitalnih tehnologija u nastavnom procesu. Cilj rada jest utvrditi kolika je zainteresiranost nastavnika za primjenu pojedinih digitalnih tehnologija u nastavi, kao i utvrditi sličnosti i razlike u njihovim potrebama za upoznavanjem i primjenom digitalnih tehnologija u nastavi u odnosu na spol i radno iskustvo nastavnika. Zaključak je da su nastavnici očitovali visoku zainteresiranost za upoznavanje i primjenu digitalnih tehnologija u nastavi. Kao najveća potreba nastavnika pokazala se primjena računala i interneta.Ključne riječi: digitalne tehnologije; obrazovne potrebe; informacijska pismenost; medijska pismenost; nastavni proces.