bluuebunny/crossref_metadata_2025 huggingface dataset:
Peningkatan Kreativitas Anak dengan Membuat Kerajinan Tangan dari Limbah dan Kardus Bagi Anak di Desa Pandansari Selatan, Kecamatan Sukoharjo, Kabupaten Pringsewu
Authors: Wahyudi Dedi , Nuryah Nuryah , Rindiana Bunga , Putri Dania Mutiara
Published: August 2024

Children in the village of South Pandansari tend to prefer playing with their cellphones, watching TV and playing with their friends rather than taking advantage of the time they have. Service activities in the form of making crafts using used goods that can be utilized. The community service team carried out this activity at the Reading Corner, to be precise, in Pandan Sari Selatan Village, Sukoharjo District, Pringsewu Regency. So that children in South Pandansari Village can work from an early age. The community service and empowerment method used is ABCD (Asset Based Community Development). The results of the community service activities that have been carried out are teaching the children of South Pandansari village to work in utilizing used goods, to start practicing creative thinking from an early age for their future and to take advantage of their free time so they are not consumed by negative things. The programs that have been implemented can be used as a reference and input to add experience or skills and encourage the creation of a more active, dynamic, healthy and prosperous society and can serve as an example for other sub-districts or villages.
Sosialisasi Pengolahan Limbah Kotoran Sapi dalam Pembuatan Biogas di Desa Madureso Kabupaten Mojokerto
Authors: Julianti Saffana Zahra  , Merry Sunaryo  , Fadeli Wibisono  , Hikmiah Syahriatul , Nirmala Kaana Taqiyyaa
Published: August 2024

Cow dung is a waste that can interfere with environmental aspects. Constantly increasing volumes without treatment can interfere with human health. This problem is still a challenge for Madureso Village, Mojokerto Regency, East Java. Economic activity is dominated by the agricultural and plantation sectors. About 70% work as farmers or ranchers, but Madureso Village does not have a different cow dung processing system. To overcome this problem, the P2MD team of the Occupational Safety and Health Student Association of Nahdlatul Ulama University Surabaya initiated waste treatment by processing cow manure into biogas and organic fertilizer. Later, the biogas can be an effort by the local community in Madureso Village, to care about environmental hygiene problems and alternative fuels. Therefore, community service activities are carried out through socialization regarding biogas processing or production. The evaluation of the socialization that has been carried out is that most participants understand the importance of cow dung processing and how to utilize the results of this waste treatment. Thus, it is hoped that the community can carry out biogas processing independently and sustainably. Based on the results obtained during the community service activities, it can be seen that the socialization activity was successful because it has increased participants' understanding of biogas. There was an increase of 94% in post-test results where previously only 61% of respondents knew about biogas.
Pendampingan Pembelajaran Tajwid Dasar Pada Santri Baru Pondok Pesantren Wali Songo Sukajadi
Authors: Badarudin  , May Roni
Published: August 2024

Pendampingan dilaksanakan dengan santri Pondok Pesantren Wali Songo Sukajadi sebagai objek dalam pelaksanaan pengabdian dengan tujuan memberikan pengetahuan berupa ilmu tajwid dasar yang bermanfaat atau membantu mempermudah santri dalam membaca serta menghafalkan Al-Qur’an. Pendampingan ini mengambil program pembelajaran atau penyuluhan dalam penerapan ilmu tajwid dalam mengembangkan bacaan Al-Qur’an yang baik dan benar. Metode yang digunakan yaitu penyuluhan dengan memberikan edukasi kepada para santri baru mengenai tata cara membaca Al-Qur’an dengan baik dan benar sesuai kaidah ilmu tajwid. Pendampingan ini dapat meningkatkan pengetahuan santri baru tentang tata cara membaca Al-Quran dan diharapkan dapat diamalkan dalam kegiatan sehari-hari. Kegiatan ini dilakukan secara langsung di Pondok Pesantren Wali Songo Sukajadi. Terdapat beberapa pendampingan pengabdian tentang pengabdian pembelajaran tajwid salah satunya adalah nama pengabdian yang dilakukan oleh Adiva Syaifullah, Farah Maulida Rahmah, Fathatus Salamah dan Triana Srisantyorini yang diterbitkan pada tahun 2020.
Pemberdayaan Masyarakat dalam Devirsivikasi Limbah Kayu Menjadi Kerajinan Wall Décor Flower Pada Komunitas Omah (TBC)
Authors: Shulton Asnawi Habib , Mardiantari Ani , Ambariyani Ambariyani , Muslih M , Irhamudin Irhamudin , Nurdin Zuhdi M , Mauliyanti Anita , Kusmawaningsih Susi
Published: August 2024

This article is about community empowerment in deviating wood waste into Wall Décor Flower crafts. This community empowerment is carried out in the Community of People Suffering from TBC, which is organized into a community called Omah (TBC). This community is located in the West Metro area of Metro Lampung City. This mentoring program is for the community to gain skills and theoretical understanding in processing wood waste to become wall decor flower crafts. In addition, wood wastes that will be used as wall décor flower crafts will reduce waste which will actually pollute the environment, with the use of wood waste, the community will get a solution in improving the community's economy. The focus of this article's study is How to Empower the Community through Devisivying Wood Waste into Wall Décor Flower Crafts in the Omah TIBI (TBC) Community in West Metro District? The service research method or strategy used in this program is the Asset-Based Community Development (ABCD) method. The ABCD method is a community service approach with an orientation so that people have the power to recognize and utilize all their strengths and assets for the good of the community.
Cirurgia para o controle de danos
Authors: Cunha Gabriela de Oliveira , Marins Nina Cavalcanti Trindade , Ramalho Maria Eduarda Motta , Silveira Lucas Zappa Monte Lima , Oliveira Paloma da Cunha Santos de Alves , Bafa Túlio Campos , Grunewald Tatiana Mara dos Santos Azevedo , Rocha Mirelli Katzuk de Carvalho , Sousa Natália Barreto e
Published: August 2024

Objetivo: Revisar sobre essa técnica crucial analisando sua evolução, indicações, protocolos e impacto nos desfechos de pacientes com trauma abdominal e politrauma, fornecendo uma visão abrangente e atualizada sobre seu papel na melhoria da assistência em situações de emergência. Revisão bibliográfica: Os traumas abdominais podem ser divididos em fechados ou penetrantes, afetando órgãos como baço, fígado e intestino delgado. Em casos de politrauma, que frequentemente envolvem múltiplas lesões, um atendimento multidisciplinar é essencial, sendo a cirurgia para controle de danos um protocolo comprovado para melhorar as chances de sobrevivência. O termo "controle de danos", originário da marinha, é adotado na medicina para procedimentos temporários que restauram a estabilidade fisiológica do paciente antes da cirurgia definitiva. Essa técnica, consiste em três etapas principais: identificação do paciente, intervenções primárias para controle de hemorragia e coagulação, seguido de cuidados intensivos para estabilização do paciente e, por fim, realização do tratamento definitivo e reconstrução. Considerações finais: A cirurgia para controle de danos emergiu como uma intervenção crucial na gestão de pacientes com trauma abdominal e politrauma. Sua aplicação tem sido amplamente reconhecida por melhorar desfechos em situações de emergência, oferecendo uma abordagem eficaz e multidisciplinar para preservar a vida e garantir a estabilidade fisiológica do paciente.
Kajian komparasi politik luar negeri Indonesia Malaysia di era pemerintahan soekarno dan soeharto, 1963-1966
Authors: Tristantri Cepi Novia , Zahidi M Syaprin
Published: August 2024

Indonesia yang baru merdeka saat itu berupaya melaksanakan politik luar negeri dengan menjadikan pancasila dan UUD 1945 sebagai landasan. Namun, hubungan antar negara tidak selamanya damai, seperti Indonesia dan Malaysia pada 1963-1966 dengan sebutan konfrontasi Malaysia. Setiap negara memiliki karakteristik kepemimpinan yang berbeda, khususnya masa soekarno dan soeharto. Penelitian bertujuan membandingkan hubungan Indonesia-Malaysia di era pemerintahan Soekarno dan Soeharto. Metode kepustakaan dan analisis deskriptif digunakan dalam penelitian ini dengan mengumpulkan sumber tertulis seperti buku, jurnal, artikel, dokumen, laporan dan arsip.Â  Hasil penelitian menunjukkan pada era Soekarno, politik luar negeri dipengaruhi semangat ant kolonial dan anti imperialisme. Masa Soeharto mengadopsi pendekatan pragmatis dan berorientasi pada stabilitas regional serta pembangunan ekonomi. Soekarno yang revolusioner dan konfrontatif berbeda dengan Soeharto yang pragmatis dan moderat. Sehingga berdampak pada orientasi politik dan diplomasi. Hasil penelitian berkontribusi untuk memahami dinamika politik regional Asia Tenggara pada pertengahan abad ke-20 sebagai pembelajaran di masa selanjutnya. Kemudian, memberikan wawasan ideologi, kepemimpinan dan konteks internasional memengaruhi kebijakan luar negeri. Keterbatasan penelitian terletak pada sumber data pada arsip, dokumen pemerintah, dan literatur sekunder sehingga kurang mencakup seluruh perspektif, terutama Malaysia.
Fungsi manajemen koperasi kepolisian Resor Ponorogo
Authors: Sari Novita Erliana , Rohman Zhainul , Riani Lilia Pasca , Prastyaningtyas Efa Wahyu
Published: August 2024

Manajemen adalah salah satu poin penting penunjang keberhasilan sebuah organisasi dalam mencapai tujuannya secara efektif dan efisien. Dalam lima tahun terakhir, Koperasi Kepolisian Resort Ponorogo berkembang cukup pesat bersaing dengan Polres lain di jajaran wilayah Jawa Timur. Untuk itu penelitian ini akan menggali informasi mengenai penerapan fungsi manajemen pada Koperasi Kepolisian Resort Ponorogo. Penelitian ini menggunakan metode deskriptif kualitatif yang berbentuk penelitian survey. Sumber data dalam penelitian ini adalah pengurus, pengawas dan anggota koperasi. Pengumpulan data dilakukan dengan menggunakan instrumen berupa wawancara, observasi, dan dokumen pendukung. Hasil observasi dan wawancara menunjukkan bahwa penerapan fungsi manajemen koperasi oleh pengurus Koperasi Kepolisian Resort Ponorogo sangat baik yang dibuktikan dengan kemampuan pengurus dalam menjalankan fungsi manajemen dengan baik sehingga anggota merasa puas dengan kinerja penguru.
Meningkatkan Kemampuan Membaca Al-Qur’an Melalui Metode Tahfizh di PAUD Fithri Desa Teluk Pulai Dalam Kualuh Leidong
Authors: Aziz Mursal , Napitupulu Dedi Sahputra , Mahdalena
Published: August 2024

Reading the Koran is one of the lessons given to young children to develop children's religious potential. The aim of this research is to describe the process of improving the ability to read the Al-Qur'an through the tahfizh method at the Early Childhood Education School in Teluk Pulai Dalam Village, Kualuh Leidong. The research method in this research is Classroom Action research. The tahfizh method used by Fithri PAUD teachers in Teluk Pulai Dalam Village little by little, with regular repetition, young children at Fithri PAUD are starting to be able to memorize one, two or three short surahs as taught by their teachers in class. Based on Classroom Action Research conducted in cycle I, information was obtained that the level of student ability in cycle I was 18% in the fluent category, 29% in the moderate category, and 53% in the poor category. After carrying out the second cycle using the Tahfizh Method, information was obtained that the level of students' ability in the second cycle was 53% in the fluent category, 29% in the moderate category, and 18% in the poor category, after carrying out the third cycle, the level of students' ability in the third cycle was 82% in the fluent category, the medium category is 18% while the less category is 0%. This shows that the Tahfizh method has a significant influence in improving the ability to read the Koran in Fithri PAUD Teluk Pulai Dalam Village, Kualuh Leidong
Penanaman Kemandirian Anak Melalui Pembiasaan Ibadah Taharah di KB Melati Indah Ponorogo
Authors: Darti Darti , Nurjan Syarifan , Irsad Rusdiani Nurtina
Published: August 2024

This study aims to examine the process of fostering independence in early childhood at KB Melati Indah. The main issue addressed is how this institution implements strategies to develop independence in young children, particularly through the habituation of thaharah practices. The research method used is descriptive qualitative, with data collection techniques including observation, interviews, and documentation. The results of the study indicate that KB Melati Indah has successfully implemented various effective strategies in fostering independence, such as providing real-life examples and involving children in daily activities that require independence. The habituation of thaharah practices is also taught consistently, helping children understand the importance of cleanliness and personal responsibility. Challenges include limited facilities and support from parents, but these can be overcome through a more integrative and participative approach. Overall, this research demonstrates that with the right strategies, educational institutions can help early childhood develop the independence necessary for their readiness in entering the next level of education.
Pengaruh Tari Rapai Geleng dalam Mengembangkan Sosial Anak Usia 5-6 Tahun di RA Safinatul Najjah Manggeng
Authors: Zahra Sri Amalia , Juwita Rani Puspa
Published: August 2024

Improving the social quality of individuals can be achieved through interaction and adaptation of behavior in society according to accepted guidelines. In this case, Rapai Geleng dance is proven as an effective tool to stimulate social growth in early childhood. This study was directed at measuring the impact of Rapai Geleng dance training on social development in children aged 5 to 6 years at RA Safinatul Najjah Manggeng. The focus of the study was on 12 children, divided into 7 girls and 5 boys. The method used is quantitative experimental with a single group testing design before and after the experiment. The study used the whole sample and collected data through observation and documentation. Data analysis used an independent t-test to compare scores before and after the experiment. The results showed a marked improvement in the social skills of the children who engaged in Rapai Geleng dance, with an increase in the mean score from 6.5 to 17.5. Hypothesis testing confirmed the significant difference in scores, resulting in a T count of 7.888 which is greater than the T table of 1.796, with degrees of freedom (df) 11 and a significance value (p-value) of 0.00, which is lower than 0.05. This data reinforces the conclusion that Rapai Geleng dance is effective in supporting children's social development.
Pemanfaatan Media Pasir Untuk Meningkatkan Kemampuan Menulis Anak Usia 5-6 Tahun
Authors: Wulandari Catur
Published: August 2024

This research aims to improve the pre-writing skills of early childhood by using sand media. The research method used is the classroom action research (PTK) method which is carried out in stages, namely planning, taking action, observing and analyzing or reflecting. The subjects of this research were 15 children aged 5-6 years in one of the schools in the city of Jakarta. Sand media was chosen because it has a texture and properties that can stimulate children's motor sensors and is expected to help children develop pre-writing skills. The results of the research show that children's writing skills in the initial conditions and cycle I have not reached the performance indicators. The results of research in the second cycle show that the use of sand media can significantly improve children's pre-writing abilities, as seen from the increase in accuracy and neatness and the shape of the letters they make. Thus, sand media can be used as an effective alternative in learning pre-writing in early childhood education.
New acetamipride-based mixed formulations
Authors: Костина М.Н. , Костин Ф.Н. , Виноградова А.И.
Published: August 2024

Изучена целевая эффективность двух новых инсектицидных препаратов, содержащих в качестве действующего вещества (ДВ) ацетамиприд в комбинации с соединениями из группы пиретроидов. Установлено острое действие для тараканов, муравьев, клопов, мух и даны рекомендации для практического применения в сфере медицинской дезинсекции и населением в условиях быта.

The target efficacy of two new insecticidal preparations containing acetamipride in combination with compounds from the group of pyrethroids as the active substance was studied. An acute effect has been established for cockroaches, ants, bedbugs, flies and recommendations are given for practical use in the field of medical pest control and by the population in everyday life
Epidemiological aspects of ascariasis in children in the Astrakhan region (based on materials from the Center for Hygiene and Epidemiology in the Astrakhan Region Federal State Health Institution)
Authors: Аракельян Р.С. , Ирдеева В.А. , Шендо Г.Л. , Абросимова Л.М. , Загина А.Н.
Published: August 2024

По материалам лаборатории бактериологических и паразитологических исследований ФБУЗ «Центр гигиены и эпидемиологии в Астраханской области проанализирована эпидемиологическая ситуация по аскаридозу детей в Астраханской области за 2015–2019 гг. Установлено, что несмотря на проводимые в регионе противоэпидемические мероприятия, аскаридоз продолжает оставаться актуальной проблемой среди взрослых и детей В большинстве случаев аскаридоз выявлен у детей дошкольного возраста, что может быть связано с несоблюдением ими правил личной гигиены и употреблением в пищу немытых фруктов и овощей, контаминированных яйцами аскарид. При аскаридозе дети чаще всего жалуются на плохой аппетит и боль в эпигастральной области. Наличие в фекалиях неоплодотворенных яиц Ascaris lumbricoides свидетельствует о наличии в организме хозяина только самок паразита (самец отсутствует).

Based on the materials of the bacteriological and parasitological research laboratory of the Federal State Health Institution “Center for Hygiene and Epidemiology in the Astrakhan Region, the epidemiological situation of ascariasis in children in the Astrakhan region for 2015–2019 is analyzed. It has been established that despite the anti-epidemic measures carried out in the region, ascariasis continues to be an urgent problem among adults and children. In most cases, ascariasis was detected in preschool children, which may be due to noncompliance with personal hygiene rules and eating unwashed fruits and vegetables contaminated with roundworm eggs. With ascariasis, children the most often complain of poor appetite and pain in the epigastric region. The presence of unfertilized Ascaris lumbricoides eggs in feces indicates the presence of only female parasites in the host organism (male is absent).
Food insecticidal bait ≪Tanzanite≫ based on a binary mixture of compounds of the entericcontact action
Authors: Костина М.Н. , Бидевкина М.В. , Виноградова А.И.
Published: August 2024

Изучена целевая эффективность и безопасность пищевой приманки Танзанит в форме геля, содержащей в качестве действующего вещества (ДВ) смесь двух соединений из различных химических групп: неоникотиноида ацетамиприда (0,5) и аналога ювенильного гормона (АЮГ) метопрена (0,25). Установлена привлекательность для ряда видов насекомых (тараканы, муравьи, мухи, осы), эффективность и длительность остаточного действия как в лабораторных, так и в натурных условиях.

The target efficacy and safety of food bait Tanzanite in the form of gel containing as an active ingredient (DV) a mixture of two compounds from different chemical groups: neonicotinoid acetamiprid (0.5) and analog of juvenile hormone (AUG) methoprene (0.25) was studied. The attractiveness for a number of insect species (cockroaches, ants, flies, wasps), the effectiveness and duration of the residual action both in laboratory and insitu conditions have been established.
Optimization of the determination of active substances in insectorodenticide means on the basis of fipronil derivatives with 4-hydroxycoumarin by the method of RP HPLC
Authors: Носикова Л.А. , Кочетов А.Н.
Published: August 2024

Рассмотрены примеры совместного определения фипронила (инсектицид фенилпиразолонового ряда) и бромадиолона (антикоагулянтный родентицид 4гидроксикумаринового ряда) методом ОФ ВЭЖХ. Осуществлена оптимизация условий экстракционного извлечения различных препаративных форм на основе этих действующих веществ, включая твердые и мягкие брикеты, содержащие в качестве матриц пищевые компоненты и парафин. Обсуждаются возможность и целесообразность оценки изомерного состава титульных производных. Найденные условия хроматографического определения в изократическом режиме открывают широкие возможности как для гармонизации методов анализа других инсектородентицидных средств на основе гомологов 4гидроксикумаринового ряда, так и для осуществления процедуры оценки поставщиков или установления факта фальсификации продукции.

Examples of joint determination of fipronil (an insecticide phenylpyrazole number) and the product appears (anticoagulant rodenticide 4hydroxycoumarin series) by the method of RP HPLC are considered. Optimization of the extraction conditions of various preparative forms on the basis on these active substances, including hard and soft briquettes containing food components and paraffin as matrices, has been carried out. The possibility and expediency of estimating the isomeric composition of title derivatives are discussed. The found conditions of chromatographic determination in the isocratic regime open wide opportunities both for harmonization of methods of analysis of other insecticidal agents on the basis of homologues of 4hydroxycumarine series and for implementation of the procedure of evaluation of suppliers or establishment of the fact of product falsification.
Approaches to quantitative evaluation of the consequences of mammal invasiations in Russia territory
Authors: Хляп Л.А. , Петросян В.Г.
Published: August 2024

Предлагается вариант экспертной оценки экономического ущерба экосистемам и человеку от инвазионных видов. Количественные оценки в баллах получены для 10 видов млекопитающих из списка 100 самых опасных инвазионных видов России: Castor canadensis Kuhl, 1820 Ondatra zibethicus Linnaeus, 1766 Apodemus agrarius (Pallas, 1771), Mus musculus Linnaeus, 1758 Rattus rattus Linnaeus, 1758 Rattus norvegicus Berkenhout, 1769 Canis familiaris L., 1758 Nyctereutes procyonoides (Gray, 1834) Procyon lotor (L., 1758) Neovison vison (Sch., 1777). Оценка ex post возможных затрат на контроль показала, что они максимальны для M. musculus, R. norvegicus, R. rattus и C. familiaris. По экспертным оценкам в баллах максимальный суммарный ущерб экосистемам и человеку на территории России причиняют R. norvegicus and M. musculus, на втором месте C. familiaris, P. lotor, C. canadensis, O. zibethicus, N. procyonoides, на третьем A. agrarius и N. vison.

A variant of expert assessment of economic damage to ecosystems and humans from invasive species is proposed. Quantitative scores obtained for 10 species of mammals from the list of 100 most dangerous invasive species in Russia: Castor canadensis Kuhl, 1820 Ondatra zibethicus Linnaeus, 1766 Apodemus agrarius (Pallas, 1771), Mus musculus Linnaeus, 1758 Rattus rattus Linnaeus, 1758 Rattus norvegicus Berkenhout, 1769 Canis familiaris L., 1758 Nyctereutes procyonoides (Gray, 1834) Procyon lotor (L., 1758) Neovison vison (Sch., 1777). Expost evaluation of the possible costs of control showed that they are maximum for M. musculus, R. norvegicus, R. rattus и C. familiaris. According to expert estimates in points, the maximum total damage to ecosystems and humans in Russia is caused by R. norvegicus and M. musculus. In second place are C. familiaris, P. lotor, C. canadensis, O. zibethicus, N. procyonoides in third A. agrarius and N. vison.
Sanitary and parasitological condition of the soil of parks and rest spaces in the city of Astrakhan
Authors: Аракельян Р.С. , Шапошникова Н.В. , Жаржаф С.А.
Published: August 2024

Авторы в своей статье рассказывают о санитарнопаразитологическом состоянии мест отдыха жителей и гостей г. Астрахани. Так, авторами были проведены исследования 55 проб почвы, отобранной из различных мест г. Астрахани (парки, скверы, места отдыха). Положительные находки отмечались в 38,2 (21 проба) были обнаружены яйца Toxocara canis и живые личинки Strongyloides stercoralis.

The authors in their article talk about the sanitaryparasitological state of recreation places for residents and guests of Astrakhan. So, the authors carried out studies of 55 soil samples taken from various places in Astrakhan (parks, squares, recreation areas). In the study of 55 soil samples, positive findings were reported in 38.2 (21 samples) Toxocara canis eggs and live larvae of Strongyloides stercoralis were found.
Infection of geogelminthesis of soil in Astrakhan region
Authors: Аракельян Р.С. , Шендо Г.Л. , Салина Ю.Б. , Салтереева С.Р. , Никешина Т.В. , Яценко А.С. , Нигдырова А.В. , Коваленко А.И.
Published: August 2024

Авторы статьи публикуют результаты анализа проб почвы, исследованных в лабораториях агрохимической и санитарной служб Астраханской области, а также в собственных лабораториях. Так, с 2014 по июнь 2019 гг. были проверены 6291 проба почвы, из которых 432 не соответствовали санитарнопаразитологическим показателям, процент пораженности составил 6,9

The authors in their article analyze the soil samples studied, studied in the laboratories of the agrochemical and sanitary services of the Astrakhan region, as well as their own research. So, from 2014 to June 2019. 6291 samples of the soil were studied, of which 432 samples did not meet the sanitary and parasitological indicators, the incidence rate was 6.9.
Ticks ixodes ricinus (Linnaeus, 1758) Of the lower Dniester River
Authors: Кравченко О.В. , Коваленко Н.В.
Published: August 2024

Современные ускоряющиеся темпы урбанизации с развитием рекреационных зон, созданием парков, отдыхом на природе, экотуризмом способствуют увеличению числа иксодовых клещей в городских ландшафтах, где клещи играют ключевую роль в передаче и сохранении многих природных очаговых заболеваний человека и сельскохозяйственных животных. Представлены результаты семилетних (20112017 гг.) исследований клещей Ixodes ricinus (Linnaeus, 1758) в зонах Нижнего Днестра, подверженных антропогенному воздействию. Рассмотрены собственные и литературные данные о географическом распределении клещей, оценены места их обитания, проведен мониторинг динамики численности клещей в зависимости от абиотических факторов, проведен обзор литературы, где особое внимание уделяется разнообразию инфекций в организме клещей I. ricinus.

The current accelerated pace of urbanization with the development of recreational areas, the creation of parks, outdoor recreation, ecotourism, increase the number of ixodic ticks in urban landscapes, where ticks play a key role in the transmission and preservation of many natural focal diseases of humans and farm animals. The results of 7-year (2011-2017) studies of Ixodes ricinus ticks (Linnaeus, 1758) in the Lower Dniester areas exposed to human impact are presented. Own and literary data on the geographical distribution of ticks were considered, their habitats were assessed, the dynamics of tick numbers were monitored depending on abiotic factors, a literature review was conducted, where particular attention is paid to the diversity of infections in the organism of I.ricinus ticks.
Sanitary and parasitological control of objects of the environment. Analysis of work 2014 – 2018 and 6 months 2019
Authors: Аракельян Р.С. , Салина Ю.Б. , Итяксова В.А. , Степаненко Е.А. , Перепечкина Е.А. , Гериев З.М.
Published: August 2024

Санитарно-паразитологические исследования одно из направлений практической деятельности учреждений Роспотребнадзора. При санитарно-паразитологическом мониторинге, являющемся составной частью социально-гигиенического мониторинга, осуществляется динамическое изучение степени контаминации объектов окружающей среды с целью прогнозирования риска заражения населения паразитарными болезнями. Объектами исследования в санитарной паразитологии являются элементы внешней среды, которые могут служить факторами передачи паразитозов, индикаторами возможного риска заражения населения и вероятности распространения возбудителей паразитарных болезней в среде обитания человека 14.

Sanitary and parasitological research is one of the areas of practical activity of institutions of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare. During sanitaryparasitological monitoring, which is an integral part of socio-hygienic monitoring, a dynamic study of the state of the degree of contamination of environmental objects is carried out in order to predict the risk of infection of the population with parasitic diseases. The objects of research in sanitary parasitology are environmental elements that can serve as factors for the transmission of parasitoses, indicators of the possible risk of infection of the population and the likelihood of spread of pathogens of parasitic diseases in the human environment 14.
About treatment against ticks in natural biotopes
Authors: Ахметшина М.Б. , Шашина Н.И. , Германт О.М.
Published: August 2024

Применение акарицидов для обработки природных биотопов с целью уничтожения популяций иксодовых клещей продолжает оставаться необходимым направлением неспецифической профилактики опасных природноочаговых инфекций. Статья содержит краткое описание опыта применения инсектоакарицидных средств для противоклещевых обработок в природных биотопах в разных странах. Сообщаются результаты трехлетнего анкетирования 48 субъектов Российской Федерации, эндемичных по клещевому вирусному энцефалиту. Обсуждаются случаи неправомерного применения инсектоакарицидных и других средств для обработки объектов в некоторых субъектах страны. Даны рекомендации по соблюдению ротации средств на основе веществ с разным механизмом действия для противоклещевых обработок с целью предотвращения развития резистентности клещевых популяций. Среди инсектоакарицидных средств, разрешенных для применения на территории РФ, в настоящее время не выявлено средств с недостаточной эффективностью.

The use of acaricides for the treatment of natural biotopes in order to eliminate populations of ixodid ticks continues to be a necessary direction of nonspecific prevention of dangerous natural-focal infec-tions. The article contains a brief description of the experience of using insecticoacaricidal agents for tick-borne treatments in natural biotopes in different countries. The results of a three-year survey of 48 subjects of the Russian Federation, endemic for tick-borne viral encephalitis, are reported. The cases of wrongful use of insectoacaricids and other means for treatment of objects in some regions of the country are discussed. Recommendations on rotation of means based on substances with different mechanisms of action for tick-borne treatments in order to prevent the development of tick-borne populations resistance are given. Among insecticoacaricids permitted for use on the territory of the Russian Federation, currently any ones with insufficient efficacy arent found.
Sanitary condition of objects of the environment of the Astrakhan region for 2014–2018
Authors: Аракельян Р.С. , Ирдеева В.А. , Шендо Г.Л. , Салина Ю.Б. , Салтереева С.Р. , Никешина Т.В. , Лендова П.С. , Гаджиева А.М.
Published: August 2024

В комплексе мероприятий по профилактике паразитарных болезней среди населения ведущее место занимает охрана и оздоровление окружающей среды от их возбудителей. Проведение санитарно-паразитологического мониторинга объектов окружающей среды, как фактора передачи паразитозов, предусматривает индикацию возбудителей и определение степени контаминации различных субстратов, в частности, почвы. Почва и песок являются наиболее эпидемиологически значимыми субстратами при геогельминтозах, в которых при благоприятных климатических условиях яйца геогельминтов длительное время сохраняются, развиваются и достигают инвазионной стадии, способствуя распространению паразитарных болезней 3.

In the complex of measures for the prevention of parasitic diseases among the population, the leading place is taken by the protection and improvement of the environment from their pathogens. Conducting sanitary-parasitological monitoring of environmental objects, as a factor in the transmission of parasitoses, provides for the indication of pathogens and the determination of the degree of contamination of various substrates, in particular, soil. Soil and sand are the most epidemiologically significant substrates for geohelminthiasis, in which, under favorable climatic conditions, geohelmintic eggs persist for a long time, develop and reach the invasive stage, contributing to the spread of parasitic diseases 3.
Insecticidal varnish – long-lasting formulation
Authors: Костина М.Н. , Костин Ф.Н. , Караев А.Л.
Published: August 2024

Изучена целевая эффективность нового инсектицидного средства в форме лака, установлено острое действие при непосредственном орошении насекомых и длительность остаточной активности при контакте их с обработанными поверхностями различного типа.

The target efficacy of a new insecticidal agent in the form of varnish has been studied, an acute effect has been established with a direct effect on insects and the duration of residual activity in contact with treated surfaces of various types.
Aspects of production and control of microcapsulated insecticide compositions. II. Analytical determination of insecticidal substances by chromatographic methods
Authors: Носикова Л.А. , Кочетов А.Н.
Published: August 2024

Рассмотрены возможности использования метода ВЭЖХ и ГЖХ при определении сложных многокомпонентных смесей инсектицидных субстанций в коммерческих композициях, произведенных с использованием технологии микрокапсулирования. Зачастую при анализе композиций, включающих инсектициды различных классов, приходится комбинировать оба метода (ВЭЖХ и ГЖХ) или использовать дорогостоящие масс-селективные типы детектирования. Дополнительно были опробованы варианты проведения оценки содержания субстанций в растворах инсектицидных микрокапсулированных средств, осуществлены различные комбинации проведения пробоподготовки и непосредственно аналитического определения. Содержание действующих веществ является важным фактором при определении пригодности средства (рабочих растворов), при этом были рассмотрены представители основных классов инсектицидных субстанций (пиретроидов, фосфорорганических производных, неоникотиноидов, фенилпиразолонов, карбаматов и пирролов). На модельных растворах установлены возможности и ограничения группового определения субстанций в препаратах с использованием стандартного хроматографического оборудования.

The possibilities of using the HPLC and GC method in determining complex multicomponent mixtures of insecticidal substances in commercial compositions produced using microencapsulation technology are considered. Often, when analyzing compositions that include representatives of different classes of insecticides, it is necessary to combine both methods (GC and HPLC), or, alternatively, use expensive massselective detection types. Additionally, options for evaluating the content of substances in solutions of insecticidal microencapsulated agents were tested, various combinations of sample preparation and analytical determination stages were carried out. The content of active substances is an important factor in determining the suitability of the agent (working solutions), while representatives of the main classes of insecticidal substances (pyrethroids, organo-phosphorus derivatives, neonicotinoids, phenylpyramolones, carbamates and pyrroles) were considered. The possibilities and limits of group determination using trivial chromatographic equipment were determined using model solutions.
About moth family (Pyralidae) pest control in the food industry
Authors: Щербаков В.В. , Толстов И.В.
Published: August 2024

Проанализированы многолетние данные мониторинга вредителей сем. Pyralidae на объектах пищевой промышленности. Наблюдается ускорение адаптации вида Plodia interpunctella Hb. к условиям артеприродной среды обитания в условиях Центральной России севернее 50° с. ш. Одновременно фиксируется снижение пресса Pl. int. внутри помещений и пропорциональный рост присутствия близкородственных видов. Обсуждаются возможные трансформации цикла развития Pl. int. на стадии диапаузы. Даны рекомендации по тактике контроля огневок в новой ситуации.

Long-term monitoring data considering Pyralidae fam. pests at food processing facilities have been analyzed. Acceleration of Plodia Interpunctella Hb adaptation to the conditions of the art-natural environment in the conditions of Central Russia north of 50 degrees north latitude is observed. At the same time, a decrease in the indoor pressure of Pl.Int. and a proportional increase in the presence of closely related species were recorded. Possible transformations of the Pl.Int. development cycle at the diapause stage and possibilities of emergence of new trophody-namics are discussed. Recommendations are given on pyralid moths control strategies in a new setting.
The relevance of restrictions in the use of rodenticide concentrates for plant protection of unprotected soil
Authors: Яковлев А.А.
Published: August 2024

Безопасность применения родентицидов как самых опасных из числа пестицидов зависит от их препаративных форм, регламентов и технологий применения. Сложнее всего соблюдать условия безопасности при использовании концентратов, из которых делают родентицидные приманки с применением зерна в условиях хозяйств. Такие препараты наиболее опасны для нецелевых теплокровных животных, для которых зерно является привлекательным кормом. Из 24 химических родентицидов для открытого грунта только 5 представляют собой концентрированные препараты. Следовательно, в Российской Федерации сложился достаточный ассортимент наименее опасных родентицидов (гранулы, брикеты, капсулы). Одновременно с этим интенсификация производства и увеличение объемов защитных обработок приводит к росту числа нецелевых отравлений. Все это является обоснованием для того, чтобы ограничить применение родентицидных концентратов защитой запасов при хранении и растений закрытого грунта, исключив использование таких пестицидов в открытом грунте.

The safety of rodenticides, as the most dangerous of the pesticides, depends on the dosage forms used, regulations and application technologies. The most difficult thing is to observe the safety conditions when using concentrates, from which rodenticide baits are made in the conditions of farms with the use of grain. Such preparations are most dangerous for non‑target warm‑blooded animals, for which grain is an attractive feed. Of the 24 chemical rodenticides for unprotected soil, only 5 are concentrated preparations. Consequently, in the Russian Federation there is a sufficient range of the least dangerous rodenticides (pellets, briquettes, capsules). At the same time, the intensification of production and the increase in the volume of protective treatments leads to an increase in the number of non‑targeted poisoning. All this is a justification for limiting the use of rodenticide concentrates to the conditions of storage of stocks and protected soil, while excluding the use of such preparations for plant protection in unprotected soil.
Discovery and Characterization of a Transient Bis(dichloromethane) Solvate of Ritonavir: A Pathway to Metastable Form IV
Authors: Parent Stephan , Smith Pamela , Bauser Haley , Radocea Adrian
Published: August 2024

This study introduces a new solid form of the antiviral drug ritonavir, specifically a bis(dichloromethane) solvate. The novel solvate was crystallized from a dichloromethane solution with hexane. The solvent is easily lost from the crystal lattice at room temperature, resulting in a known metastable anhydrate form, ritonavir Form IV. The desolvation process was monitored by powder X-ray diffraction over 6 hours using multiple scans. Indexing, along with unit-cell refinement by Pawley fit, were performed for both the novel ritonavir-bis(dichloromethane) solvate and metastable ritonavir Form IV. The presented desolvation of the novel solvate provides a simplified pathway for the isolation of metastable Form IV.
Pulsed EPR Methods in the Angstrom to Nanometre Scale Shed Light on the Conformational Flexibility of a Fluoride Riboswitch
Authors: Remmel Laura , Meyer Andreas , Ackermann Katrin , Hagelüken Gregor , Bennati Marina , Bode Bela
Published: August 2024

Riboswitches control gene regulation upon external stimuli such as environmental factors or ligand binding. The fluoride sensing riboswitch from Thermotoga petrophila is a complex regulatory RNA proposed to be involved in resistance to F- cytotoxicity. The details of structure and dynamics underpinning the regulatory mechanism are currently debated. Here we demonstrate that a combination of pulsed electron paramagnetic resonance (ESR/EPR) spectroscopies, detecting distances in the angstrom to nanometre range, can probe distinct regions of conformational flexibility in this riboswitch. PELDOR (pulsed electron-electron double resonance) revealed a similar preorganisation of the sensing domain in three forms, i.e. the free aptamer, the MgII-bound apo, and the F--bound holo form. 19F ENDOR (electron-nuclear double resonance) was used to investigate the active site structure of the F--bound holo form. Distance distributions without a priori structural information were compared with in silico modelling of spin label conformations based on the crystal structure. While PELDOR, probing longer distances, revealed varying conformational flexibility of the RNA backbone, ENDOR indicated low structural heterogeneity at the ligand binding site. Overall, the combination of PELDOR and ENDOR with sub-angstrom precision gave insight into structural organisation and flexibility of a riboswitch, not easily attainable by other biophysical techniques.
CySP3-96 enables scalable, streamlined, and low-cost sample preparation for cysteine chemoproteomic applications
Authors: Shikwana Flowreen , Heydari Beeta , Ofori Samuel , Truong Cindy , Turmon Alexandra , Darrouj Joelle , Holoidovsky Lara , Gustafson Jeffrey , Backus Keriann
Published: August 2024

Cysteine chemoproteomic screening platforms are widely utilized for chemical probe and drug discovery campaigns. Chemoproteomic compound screens, which use a mass spectrometry-based proteomic readout, can interrogate the structure activity relationship (SAR) for thousands of proteins in parallel across the proteome. The versatility of chemoproteomic screens has been demonstrated across electrophilic, nucleophilic, and reversible classes of molecules. However, a key bottleneck that remains for these approaches is the low throughput nature of most established sample preparation workflows, which rely on many time-intensive and often error prone steps. Addressing these challenges, here we establish a novel workflow, termed CySP3-96, that pairs single-pot, solid-phase-enhanced, sample preparation (SP3) with a customized 96-well sample cleanup workflow to achieve streamlined multiplexed sample preparation. Our CySP3-96 method addresses prior volume limitations of SP3, which allows for seamless 96-well chemoproteomic sample preparation, including for large input amounts that are incompatible with prior methods. By deploying CySP3-96 to screen a focused set of 16 cysteine-reactive compounds, we identify 2633 total ligandable cysteines, including 21 not captured in CysDB. Chemoproteomic analysis of a pair of atropisomeric electrophilic kinase inhibitors reveals striking stereoselective cysteine ligandability for 67 targets across the proteome. When paired with our innovative budget friendly magnetic resin, CySP3-96 represents a versatile, low cost, and highly reproducible screening platform with widespread applications spanning all types of chemoproteomic studies.
Rhenium tricarbonyl complexes of thiazolohydrazinylidene-chroman-2,4-diones derivatives: antibacterial activity and in vivo efficacy.
Authors: Rahmani Fatlinda , Demirci Gozde , Plackic Nikola , Tran Bettina , Crochet Aurelien , Cortat Youri , Salentinig Stefan , Pavic Aleksandar , Zobi Fabio
Published: August 2024

Antimicrobial resistance (AMR) is a major threat to public health, causing serious issues in the successful prevention and treatment of persistent diseases. Transition metal complexes are currently evaluated for the possible development of alternative antimicrobial agents. In our ongoing efforts to identify safe and effective rhenium-based antibiotics, we have prepared a family of compounds bearing derivatives of thiazolohydrazinylidene-chroman-2,4-diones. Two compounds were identified as being active and nontoxic in vivo (zebrafish-S. aureus ATCC43300 model of infection), efficiently eradicating Methicillin-resistant Staphylococcus aureus (MRSA) infection at doses of 500 and 520 ng/mL respectively. In vitro studies indicate that, contrary to other known active rhenium complexes, the compounds do not affect peptidoglycan synthesis or compromise the integrity of the cytoplasmic membrane, but rather that bacterial membrane depolarization may play a role in their antibiotic activity.
Internal reference for determining orientation of alignment in liquid crystal cells by confocal polarised Raman microscopy
Authors: Feringa Ruben , Klement J. M. Bas , Sears Jasmine , van der Zaag Pieter J. , Browne Wesley R.
Published: August 2024

The phase adopted by liquid crystals, in applications such as displays, is controlled by alignment layers. Typically this phase originates from a layer of unidirectionally rubbed polymer on a solid support. The extent to which the alignment layer orders the liquid crystal can be determined by the transmission of polarised light, however this quantifies the net effect of the alignment over the entire depth of the LC layer. The polarisation dependence of the Raman scattering of liquid crystal molecules, e.g., 5CB, can allow for molecular anisotropic ordering (alignment) at the interface to be characterised directly by polarised Raman microspectroscopy. However, the optical properties of the oriented LC phases and ITO on glass electrodes impacts the depth resolution achievable. Here we introduce a resonance Raman active component, [Fe(bpy)3](BArF)2, into a PMMA alignment layer as an isotropic reference for Raman scattering. The Raman scattering from this complex is insensitive to the directing of polarisation of the excitation laser and enables estimation of the confocal depth probed in complete liquid crystal cells. The Raman scattering of [Fe(bpy)3](BArF)2 in the PMMA allows for changes in LC orientation near the interface to be followed and compared with changes to the orientation of molecules in the bulk of the liquid crystal. This approach provides spatial resolution (depth) when studying the realignment of LC molecules by electric fields and enables the balance in orientational control by the alignment layer and the electric field to be assessed.