bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelo predictivo para la identificación de la fracción volumétrica en flujo bifásico
Authors: Ruiz-Diaz C M , Hernández-Cely M. M , González-Estrada O. A
Published: September 2021

Este trabajo presenta el uso de inteligencia artificial en flujos multifásicos, implementando una red neuronal artificial de perceptrón multicapa con retropropagación, y utilizando la función de activación tangente sigmoidea, para generar un modelo predictivo capaz de obtener la fracción volumétrica de un flujo bifásico compuesto por agua y aceite mineral en una tubería horizontal de 12 m. La red neuronal artificial se desarrolla a partir de una capa de entrada, formada por el diferencial de presión en la línea y las velocidades superficiales de los fluidos de trabajo, además, tiene dos capas ocultas y una capa de salida, que está formada por las fracciones volumétricas de los fluidos. El modelo predictivo de mejor rendimiento muestra un error medio porcentual absoluto del 3,07 % y un coeficiente de determinación R2 de 0,985 utilizando 15 neuronas en las dos capas ocultas de la red neuronal. Los 56 datos experimentales utilizados en el estudio se obtuvieron en el laboratorio LEMI EESC-USP (Brasil).
Advances in mechanical weed control technologies
Authors:   Aarhus University, Denmark, Melander Bo , McCollough Margaret R. ,   Aarhus University, Denmark
Published: September 2021

Mechanical weed control can be grouped into three categories: full-width cultivators, inter-row cultivators and intra-row cultivators. This chapter will highlight the most recent and relevant advances within each category. The focus will be on novel inventions and developments of mechanical devices, designs, and the weed problems they are meant to solve. Moreover, automation technologies that assist weeding operations are becoming increasingly important and will be given special attention.
As formas e as reformas da identidade xavante: uma abordagem metodológica
Authors:   Universidade do Estado do Rio de Janeiro, Campos Maria Cristina Rezende de
Published: September 2021

Este estudo busca uma compreensão sobre as formas artísticas e culturais que identificam a sociedade Xavante e suas transformações acarretadas pelo contato com o homem “branco”. É um estudo comparativo sobre os aspectos observados pelos antropólogos Maybury-Lewis e Regina Müller e a pesquisa de campo que estou desenvolvendo nas Aldeias Abelhinha e Sangradouro, no Estado Mato Grosso. Evidencio a forma de organização dualista em que a Sociedade Xavante trabalha para criar uma síntese harmônica, a partir de idéias, categorias e instituições antitéticas que constituem seu modo de vida. E, também, as marcas identitárias impregnadas de códigos comunicantes, que têm na ornamentação corporal expressão simbólica.
Luzes e sombras na relação entre arte e psicanálise
Authors:   Universidade de São Paulo, Freitas Nivaldo Alexandre de
Published: September 2021

Este artigo visa expor algumas relações entre arte e psicanálise a partir da Teoria Crítica da Escola de Frankfurt. A psicanálise é uma teoria que possui elementos para iluminar não apenas o momento do artista no processo de elaboração da arte, mas também para apontar como a arte se encontra enredada em dificuldades, como a ameaça de se transformar em mera mercadoria, como mais um meio da indústria cultural. Por outro lado, às vezes a psicanálise é usada seguindo as tendências das reduções biográficas que dão ao artista a total responsabilidade por sua obra, quando a sociedade também se faz presente em sua composição. A psicanálise como ciência ainda pode deixar para trás achados importantes que a arte traz a tona, pois esta é considerada menos fiel à descrição do indivíduo e de sua relação com a sociedade: quem quiser saber sobre o psiquismo não recorrerá a artistas que tem muito a falar sobre ele, mas à ciência que se consolida como a mais apropriada para tal, e que encerra a arte na sombra de seus conceitos.
A aparição do menino Jesus a Santo Antônio de Pádua do MASP: Santo Antônio ou São Francisco?
Authors:   Universidade Estadual de Campinas, Decarli Christine
Published: September 2021

Texto apresentado no II Encontro de História da Arte.
Questões de autenticidade na era do patrimônio espetacular
Authors:   Universidade de São Paulo, Henning Priscila
Published: September 2021

Atualmente, a questão da preservação de nosso legado arquitetônico, histórico e/ou artístico vem sendo amplamente discutida, não apenas no meio acadêmico, como pela sociedade em geral. Por todo o país surgem cada vez mais projetos de preservação cultural que unem tanto as iniciativas privadas quanto organismos públicos, muitas vezes aplaudidos pela mídia e apoiados pelos usuários. A princípio, este quadro é positivo e benéfico, pois estimula a conservação de nossos bens culturais e a retomada da própria identidade da sociedade a partir de sua trajetória ao longo do tempo. No entanto, a associação insistente da preservação do patrimônio com a indústria cultural do espetáculo, incluindo neste contexto a relação indissociável com o turismo espetacular e as distorções geradas pela indústria da informação, faz com que seja necessária a discussão de um conceito basilar que pauta a ação do preservador: a questão da autenticidade. O conceito de autenticidade desperta algumas das questões essenciais que cercam a preservação do patrimônio cultural: o que se está preservando, de que forma, e por quê? Esta questão é crucial: a partir da noção de que o bem em si, ou as dinâmicas sociais e históricas que este encerra, são justificativas para a sua conservação, torna-se necessário investigar as razões para sua distorção, desfiguração ou modificação deliberada. Para fins deste trabalho, a noção do espetáculo é ressaltada por ser uma relação contraditória, aparentemente positiva, porém que atinge diretamente a própria essência do patrimônio cultural. Ao mesmo tempo, é um espelho da sociedade contemporânea, de seus valores e mecanismos, e de sua relação com a cultura, gerando uma complexa dinâmica de significados e relações que influenciam diretamente a ação e compreensão da preservação do patrimônio cultural.
Arte e mulher algumas: leituras de contexto
Authors:   Universidade do Estado de Santa Catarina, Horn Maria Lucila
Published: September 2021

Tendo como pressuposto que não existe sociedade sem imaginação simbólica, podemos supor que a arte ainda está ligada a vida. Muito embora, algumas vezes chegamos a pensar que a vida não viva mais "a arte". A partir deste pensamento, de que a arte está ligada à vida e a imaginação simbólica de uma determinada cultura, que a arte é produção de uma sociedade, este artigo propõe uma primeira leitura para o assunto em questão a relação entre sociedade e imaginário, buscando construir uma iconografia do corpo feminino, como mensagens para além do verbal. O corpo e sua representação, aqui são textos onde se pode ler questões culturais, sociais, históricas, políticas, onde se faz a representação da mulher na história da Arte – corpos nus e corpos vestidos; a arte como representação da intimidade e a docilização dos corpos; e a mulher artista e as condições de acesso das mulheres à cultura.
Resgate da Memória em Cândido Portinari
Authors:   Universidade de Brasília, Lourenço Emília Vicente
Published: September 2021

O presente trabalho, fragmento da pesquisa em desenvolvimento no Programa de Pósgraduação do Instituto de Artes da Universidade de Brasília, tem como objetivo analisar o fenômeno da memória dentro do campo antropológico. Para tanto, foi utilizado como aporte pictórico o projeto em cartão para mosaico da obra “Jesus e os Apóstolos”, de Cândido Portinari. O objetivo norteador do trabalho é o estudo da lacuna existente entre o projeto e o mosaico, que não chegou a ser realizado, e o resgate da “memória de esquecimento”, correspondido entre os anos de 1958 e 2003. A questão da simbologia presente na obra também é levada em consideração através de uma análise formal da iconologia central da obra, que faz parte de uma memória comum e cujo icograma é representado desde o período paleocristão.
Considerações sobre a obra Madona com menino e São João Batista da fundação Eva Klabin
Authors:   Universidade do Estado do Rio de Janeiro, Marinho Fernanda
Published: September 2021

Apesar de atualmente ser atribuída na Fundação Eva Klabin a Sandro Botticelli, a pintura Madona com Menino e São João Batista, possui uma autografia polêmica que também já circundou os nomes de Lorenzo di Credi e Filippino Lippi. Seu estilo predominantemente clássico traça uma forte relação com a tradição florentina do Renascimento. Apresenta uma notável qualidade pictórica, mas com as diversas restaurações e limpezas pelas quais passou, seus traços originais foram sendo encobertos, dificultando assim o seu estudo iconográfico e autográfico. A sua análise, portanto, visa prioritariamente a abordagem de uma discussão de possibilidades de autoria segundo aproximações estilísticas, relevando os nomes já sugeridos.
The Effectiveness of Bandotan (Ageratum conyzoides L.) Leaf Extract on Mortality of Boophilus microplus In Vitro
Authors: Widyawati Dwi Retno , Hamid Iwan Sahrial , Sukmanadi Moh. , Sudjarwo Sri Agus , Hambal Muhammad
Published: September 2021

The purpose of this research is to find the effectiveness of bandotan’s (Ageratum conyzoides L.) leaf extract on mortality of Boophilus microplus in vitro and also to get of lethal concentration and lethal time. This research used 125 Boophilus microplus. This research used five treatments, namely neguvon suspensionon (K+), ethanol 1% (K-), 1% concentration (P1), 2% concentration (P2) and 3% concentration (P3). The observation of mortality was done every six hours. Boophilus microplus dies when there is no movement. The data were analyzed using one-way ANOVA and followed by Duncan's Multiple Distance Test. The result is said to be significant if p<0.05. Probit analysis of LC50 is 1.63% at the first hour, 0.85% at the second hour, 0.54% at the third hour, 0.34% at the fourth hour, 0.04% at the fifth hour and 0.04% at the sixth hour, LC90 reached by using 5.6%, 2.9%, 1.8%, 1.2%, 0.16 and 0.16% concentration in 1, 2, 3, 4, 5 and 6 hours, respectively. The LT50 of ethanol 1% (K-) was at 10.142 hours, neguvon suspension on (K+) was at 0.747 hours, 1% concentration (P1) was at 2.184 hours, 2% concentration (P2) was at 1.579 hours, 3% concentration (P3) was at 0.923 hours and LT90 was at 23.734, 1.749, 5.110, 3.695 and 2.159 hours. The conclusion of this study was bandotan’s (Ageratum conyzoides L.) leaf extract was effective as an acaricide based on the mortality of Boophilus microplus.
PENERAPAN SUPERVISI AKADEMIK UNTUMENINGKATKAN KEMAMPUAN GURU DALAM MENYUSUN RENCANA PELAKSANAAN PEMBELAJARAN KURIKULUM 2013
Authors: Idaham Idaham
Published: September 2021

This study aims to improve teachers' ability to compile the lesson plan based on the 2013 curriculum through academic supervision at SDN Kepayang Tapin Regency. This research is a school action research conducted in two cycles. The subjects of this study were the three teachers (teachers grade 1, 2, and 3 at SDN Kepayang. The instrument used was the planning of the lesson plan observation sheet and the implementation of the lesson plan observation sheet. Quantitative descriptive techniques analyzed data. The results showed the ability of classroom teachers in developing lesson plans based on the curriculum in 2013 of five indicators are considered: (1) the percentage of individual completeness of 63.4 and classical completeness of 33.33 in cycle 1; (2) the percentage of individual completeness 76 and classical completeness of 100 in cycle 2. Based on the research results, it can be concluded that academic supervision can improve classroom teachers' ability to prepare lesson plans based on the 2013 curriculum.Keywords: Academic Supervision; 2013 Curriculum; Lesson plan; Teacher AbilityAbstrak. Penelitian ini bertujuan meningkatkan kemampuan guru dalam menyusun Rencana Pelaksanaan Pembelajaran (RPP) berdasarkan kurikulum 2013 melalui supervisi akademik di Sekolah Dasar Negeri (SDN) Kepayang Kabupaten Tapin. Penelitian adalah penelitian tindakan sekolah yang dilaksanakan sebanyak dua siklus. Subjek penelitian ini adalah tiga orang guru (guru kelas 1, 2, dan 3) di SDN Kepayang. Instrumen yang digunakan adalah lembar observasi perencanaan RPP dan lembar observasi keterlaksanaan RPP. Data dianalisis dengan menggunakan teknik deskriptif kuantitatif. Hasil penelitian menunjukkan kemampuan guru kelas dalam menyusun RPP berdasarkan kurikulum 2013 dari lima indikator yang dinilai yaitu (1) persentase ketuntasan individual 63,4 dan ketuntasan klasikal 33,33 pada siklus 1; (2) persentase ketuntasan individual 76 dan tuntas secara klasikal 100 pada siklus 2. Berdasarkan hasil penelitian dapat disimpulkan supervisi akademik dapat meningkatkan kompetensi guru kelas dalam menyusun RPP berdasarkan kurikulum 2013. Kata Kunci:  Supervisi Akademik; Kurikulum 2013; Rencana Pelaksanaan Pembelajaran;Kemampuan Guru
Should Pertrochanteric and Subtrochanteric Fractures Be Treated with a Short or Long Intramedullary Nail?
Authors: Viberg Bjarke , Eriksen Lasse , Højsager Katia D. , Højsager Frederik D. , Lauritsen Jens , Palm Henrik , Overgaard Søren
Published: September 2021

Background:

The purpose of the present multicenter cohort study was to compare the rates of reoperation in elderly patients with pertrochanteric and subtrochanteric fractures that had been treated with a short or long intramedullary nail.

Methods:

Eleven orthopaedic departments across Denmark delivered data that had been obtained from the Danish Multidisciplinary Hip Fracture Registry (DMHFR) and a review of health-care records. With use of surgical procedure codes for pertrochanteric and subtrochanteric fractures that had been treated with an intramedullary nail, the DMRHF was searched to identify patients who had been ≥65 years of age between 2008 and 2013. The health-care records for patients who had had major reoperations, defined as any reoperation with the exclusion of simple hardware removal, were retrieved from the DMHFR, were reviewed for the type of intramedullary nail and missed reoperations, including peri-implant fractures, within 2 years of follow-up. Crude logistic regression analysis with adjustment for age, sex, and comorbidity was performed, yielding odds ratios (ORs) with 95% confidence intervals (CIs).

Results:

Of 2,245 pertrochanteric fractures, 1,867 were treated with a short intramedullary nail and 378 were treated with a long intramedullary nail. The rate of major reoperations was 4.0% in the short intramedullary nail group and 6.3% in the long intramedullary nail group. This yielded a crude OR of 1.61 (1.01 to 2.60) and an adjusted OR of 1.67 (1.04 to 2.70). Of 909 subtrochanteric fractures, 308 were treated with a short intramedullary nail and 601 were treated with a long intramedullary nail. The rate of major reoperations was 8.4% in the short intramedullary nail group and 4.0% in the long intramedullary nail group, yielding a crude OR of 0.45 (0.25 to 0.80) and an adjusted OR of 0.45 (0.25 to 0.81).

Conclusions:

This is the first study confirming the theory that, for subtrochanteric fractures, a long intramedullary nail has a lower rate of major reoperations compared with a short intramedullary nail. In contrast, a short intramedullary nail has a lower rate of major reoperations compared with a long intramedullary nail for pertrochanteric fractures but with a lower absolute risk reduction compared with the results for subtrochanteric intramedullary nailing. There is a need for validation of these results in other large studies, especially for pertrochanteric fractures.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Bat Intelligence For Tunning Power System Stabilizer At Barru Power Plant
Authors: Djalal Muhammad Ruswandi , Pangkung Andareas , Sonong Sonong , Apollo Apollo
Published: September 2021

Changes in load on the power system suddenly, can cause dynamic disruption. This disturbance can not be responded well by the generator, so it can affect the system dynamic stability, such as the occurrence of oscillation speed and rotor angle. Conventional control of excitation and governor, also unable to repair the oscillations, so that additional controllers such as Power System Stabilizer (PSS) are required. In the use of PSS, there are several problems that often arise, namely the correct tuning of PSS parameters. In this research, we proposed a method of smart computing based on bat algorithm, for tuning PSS parameters. From the analysis results can be concluded, the performance performance of generator barru increased with the installation of Power System Stabilizer with optimal PSS parameter, with parameters respectively Kpss = 44.0828, T1 = 0.0284, T2 = 0.0146, T3 = 0.7818, T4 = 1.2816.
Enhancement of Heavy Oil Recovery with High CO2 Injection Rates in Silica Nanochannel
Authors: Zhang Shuo , Zhang Yanyu , Sun Xiaofei
Published: September 2021

CO2 injection enhanced oil recovery has become one of the most important approaches to develop heavy oil from reservoirs. However, the microscopic displacement behavior of heavy oil in the nanochannel is still not fully understood. In this paper, we use CO2 as the displacing agent to investigate the displacement of heavy oil molecules confined between the hydroxylated silica nanochannel by nonequilibrium molecular dynamics simulations. We find that for heavy oil molecules, it requires more much higher displacing speed to fully dissipate the residual oil which is found related to the decreased CO2 adsorption on the silica nanochannel. A faster CO2 gas injection rate will lower the CO2 adsorption inside the nanochannel, and more CO2 will participate in the displacement of the heavy oil. The results from this work will enhance our understanding of the CO2 gas displacing heavy oil recovery and design guidelines for heavy oil recovery applications.
La Educación virtual en el pensamiento crítico de los estudiantes universitarios
Authors: Valencia Morocho Carlos Arturo
Published: September 2021

El objetivo fue determinar la influencia que genera la educación virtual en el pensamiento crítico en los estudiantes durante la pandemia. Corresponde al paradigma positivista, tipo aplicada, nivel explicativo, enfoque cuantitativo, método hipotético-deductivo, diseño cuasiexperimental. La muestra fue no probabilística y estuvo conformada por 68 estudiantes, divididos en el grupo experimental con 35 estudiantes y el grupo control con 33 estudiantes. A ambos se les aplicó un pretest con una prueba de 20 ítems con textos argumentativos para evaluar el pensamiento crítico. Al grupo control se le aplicó en modalidad virtual con la enseñanza tradicional y al grupo experimental, el programa de enseñanza virtual a través del foro de discusión. Prueba similar se aplicó a ambos grupos en el postest. Después de la aplicación del programa, son significativos los resultados obtenidos por medio de la prueba de la U de Mann Whitney (81,00, Z = –6,142 < ,05). En conclusión, la educación virtual influye significativamente en el pensamiento crítico.
World War III Analysis Using Signed Social Networks
Authors: Chowdhury Ranjana Roy , Gupta Shivam , Chede Sravanthi
Published: September 2021

In the recent period of time with a lot of social platforms emerging, the relationships among various units can be framed with respect to either positive, negative or no relation. These units can be individuals, countries or others that form the basic structural component of a signed network. These signed networks picture a dynamic characteristic of the graph so formed allowing only few combinations of signs that brings the structural balance theorem in picture. Structural balance theory affirms that signed social networks tend to be organized so as to avoid conflictual situations, corresponding to cycles of unstable relations. The aim of structural balance in networks is to find proper partitions of nodes that guarantee equilibrium in the system allowing only few combination triangles with signed edges to be permitted in graph. Most of the works in this field of networking have either explained the importance of signed graph or have applied the balance theorem and tried to solve problems. Following the recent time trends with each nation emerging to be superior and competing to be the best, the probable doubt of happening of WW-III(World War-III) comes into every individuals mind. Nevertheless, our paper aims at answering some of the interesting questions on World War-III. In this project we have worked with the creation of a signed graph picturing the World War-III participating countries as nodes and have predicted the best possible coalition of countries that will be formed during war. Also, we have visually depicted the number of communities that will be formed in this war and the participating countries in each communities. Our paper involves extensive analysis on the various parameters influencing the above predictions and also creation of a new data-set of World War -III that contains the pairwise relationship data of countries with various parameters influencing prediction. This paper also validates and analyses the predicted result.
Transdisciplinarity of India's Master's Level Public Health Programmes: Evidence from Admission Criteria of the Programmes Offered Since 1995
Authors: Ilangovan Kumaravel , Muthappan Sendhilkumar , Govindarajan Keerthiga , Vairamani Vignesh , Venkatasamy Vettrichelvan , Ponnaiah Manickam
Published: September 2021

BackgroundIn Indian subcontinent, Master's level public health (MPH) programmes attract graduates of diverse academic disciplines from health and non-health sciences alike. Considering the current and futuristic importance of the public health cadre, we described them and reviewed their transdisciplinarity status based on MPH admissibility criteria 1995 to 2021. MethodsUsing a search strategy, we abstracted information available in the public domain on MPH and their admissibility criteria. We classified disciplines specified for admission into Science, Social sciences and Arts, Health and Non-health categories. We described the MPH programmes by location, type of institutions, course duration, pedagogical methods, specialisations offered, and nature of admission criteria statements. We calculated descriptive statistics for eligible educational qualifications for admission to MPH programmes. ResultsOverall, 74 Indian institutions offered 88 MPH programmes. We included 85 for review. These programmes represent 50% increase (n=44) from that of 2016-17. They are mostly concentrated in 21 provinces and union territories of India. These programmes stated that they admit candidates of but not limited to "graduation in any life sciences", "three-year bachelors degree in any discipline", “graduation from any Indian universities”, and "graduation in any discipline". Of the 72 institutions, 14 admit multidisciplinary academic graduates in their 16 programmes. Except three institutions from public sector, 69 provide MPH admission opportunities to multidisciplinary health and non-health academic graduates. ConclusionOur review suggests that India's MPH programmes are less transdisciplinary. India's Master's level public health programmes should transcend to be more inclusive and admit graduates of various academic educational backgrounds.
Different Soil Salinity Imparts Clear Alteration in Rhizospheric Bacterial Community Dynamics in Rice and Peanut.
Authors: Islam Md Majharul , Bhattacharya Rajarshi , Sarkar Biraj , Maiti Pulak Kumar , Mahanty Shouvik , Chaudhuri Punarbasu , Biswas Swadesh Ranjan , Mandal Sukhendu
Published: September 2021

The rhizospheric microbiome is capable of changing the physio-chemical properties of its own micro-environment and found to be indispensable in overall health of the host-plant. The interplay between the rhizospheric environment and the microbiota residing therein tune the physiology of the associated plant. In this study, we have determined how the soil properties and the host-plant remains as an important parameter for microbial community-dynamics in the rhizosphere of rice and peanut. In addition to check the physio-chemical parameters of the rhizospheric soil, we have also prepared the metagenomic DNA from each rhizospheric soil followed by high-throughput sequencing and sequence-analysis to predict the OTUs that represents the community structure. The alpha-diversity of the bacterial community in the RRN sample was highest, while the lowest was in PRS sample. Actinobacteria is the most predominant phylum in PRN, PRS and RRN whereas Acidobacteria in RRS. We found a clear shift in bacterial community over the rice and peanut rhizosphere and also over these host-rhizospheres from normal and high saline region. The rhizospheric bacterial community composition found to be affected by the close-by environmental factors. Thus, the rhizospheric bacterial community-structure is related to both the adjoining soil characters and the type of the hosts.
Short Term Effect of the COVID-19 Pandemic On Progress Test Outcomes and Emotional State of Medical Students: A Quantitative and Qualitative Analysis
Authors: Berlin Progress Test Medizin Charité Universitätsmedizin , Sehy Victoria , Atanet Iván Roselló , Sieg Miriam , Struzena Jana , März Maren
Published: September 2021

Background The COVID-19 pandemic has been the source of many challenges for medical students worldwide. The authors examined short-term effects on knowledge gain as well as shifts in learning behavior and study-related emotional states.Method The development of knowledge gain was measured comparing the outcomes of shared questions within Progress Test (PT) pairs. The authors used mixed-effect regression models and compared the absolute variations in the percentage of correct answers per subject. Three successive test pairs were analyzed in this manner: PT36-PT41 (both conducted before the pandemic), PT37-PT42 (PT37 took place before the pandemic; PT42 was conducted from April 2020 onwards) and PT38-PT43 (PT38 was administered before the pandemic; PT43 started in November 2020). A survey including closed and open-ended questions was also carried out in January 2021 with the purpose of assessing the learning behavior and emotional state of participants. Open-ended responses were analyzed using Latent Dirichlet Allocation. Results The most recent test of each PT-pair showed a higher mean score compared to the previous test in the same pair (PT36-PT41: 2.53 (95% CI: 1.31-3.75), PT37-PT42: 3.72 (2.57-4.88), PT38-PT43: 5.59 (4.37-6-81)). Analogously, an increase in the share of correct answers was observed for most medical disciplines, with Epidemiology showing the most remarkable upsurge.N=2,715 students from eleven different German-speaking faculties participated in the survey. Respondents were mostly positive towards online lectures, which were perceived as clearly beneficial, allowing for more time and flexibility. On the other hand, the suspension of practical lessons and alleged communicational and organizational shortcomings were seen as the main disadvantages. 28% of the students did not perceive negative impacts on their emotional state regarding their studies, however, 20% of the surveyed students found it difficult to cope with the lack of social contacts, with an additional 8% of them claiming to feel lonely, demotivated or abandoned.Conclusion: Overall, PT performance improved during the pandemic. Students see advantages in online lectures, but disadvantages in the cancellation of practical lectures; they miss their former social interactions and some even show signs of emotional distress.
Multi Core DN​N based IDS for Botnet Attacks using KPCA Reduction Techniques
Authors: S Sharmila B , Nagapadma Rohini
Published: September 2021

Research on network security has recently acquired attention in the field of the Internet of Things. In the context of security, most of the IoT devices with the internet are connected directly which results in the exploitation of private data. Nowadays, the fraudster will release novel attacks very frequently especially for IoT devices. As a result, the traditional sophisticated Intrusion Detection System (IDS) model is not suitable for the identification of vulnerabilities in IoT devices. In our research work, we propose MCDNN for IDS. MCDNN is Multi Core DNN with having parallel optimizer. Rather than a traditional dataset, this paper experiment is conducted on the BoTIoT dataset. Since IoT devices generate a huge volume of data, this work focuses on reducing huge datasets using Kernel Principal Component Analysis(KPCA) reduction technique with optimizer parallelly. To decrease false alarm rate and maintaining less computational power multi-core is introduced in our research work. This helps identification of vulnerabilities in IoT devices using deep learning techniques faster. Experimental results indicate that designing MCDNN based IDS with different optimizers parallelly achieved higher performance than those of other techniques.
Role of Adenosine Kinase In Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities
Authors: Lauro Filomena , Giancotti Luigino Antonio , Kolar Grant , Harada Caron , Harmon Taylor A , Garrett Timothy J , Salvemini Daniela
Published: September 2021

Emerging evidence implicates the sphingosine-1-phosphate (S1P) receptor subtype 1 (S1PR1) in the development of neuropathic pain. Continued investigation of the signaling pathways downstream of S1PR1 are needed to support development of S1PR1 antagonists. In rodents, intrathecal (i.th.) injection of SEW2871, a selective S1PR1 agonist, activates the nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, increases interleukin-1β (IL-1β) and causes behavioral hypersensitivity. I.th. injection of a IL-1β receptor antagonist blocks SEW2871-induced hypersensitivity, suggesting that IL-1β contributes to S1PR1’s actions. Interestingly, previous studies have suggested that IL-1β increases the expression/activity of adenosine kinase (ADK), a key regulator of adenosine signaling at its receptors (ARs). Increased ADK expression reduces adenosine signaling whereas inhibiting ADK restores the action of adenosine. Here, we show that SEW287-induced behavioral hypersensitivity is associated with increased expression of ADK in astrocytes of the dorsal horn of the spinal cord (DH-SC). Moreover, the ADK inhibitor, ABT702, blocks SEW2871-induced hypersensitivity. These findings link ADK activation to S1PR1. If SEW2871-induced pain is mediated by IL-1β, which in turn activates ADK and leads to mechano-allodynia, then blocking ADK should attenuate IL-1β effects. In support of this idea, recombinant rat (rrIL-1β)-induced allodynia was blocked by at least 90% with ABT702, functionally linking ADK to IL-1β. Moreover, the selective A3AR antagonist, MRS1523, prevents the ability of ABT702 to block SEW2871 and IL-1β-induced allodynia, implicating A3AR signaling in the beneficial effects exerted by ABT702. Our findings provide novel mechanistic insight into how S1PR1 signaling in the spinal cord produces hypersensitivity through IL1-b and ADK activation.
Pedobacter Aquae Sp. Nov., A Multi-Drug Resistant Bacterium Isolated from Fresh Water
Authors: Chau Le Tran Tien , Kim Yong-Seok , Cha Chang-Jun
Published: September 2021

A novel bacterial strain designated CJ43T was isolated from fresh water located in Jeongseon-gun, Gangwon-do, South Korea, displaying multi-drug resistance. The isolate was observed to be Gram-stain-negative, aerobic, orange-pigmented, and rod-shaped. Strain CJ43T grew optimally at 30 ℃ and pH 7 on R2A agar in the absence of NaCl. Phylogenetic analyses based on 16S rRNA gene sequences revealed that strain CJ43T belongs to the genus Pedobacter in the family Sphingobacteriaceae and was the most closely related to Pedobacter glucosidilyticus 1-2T (98.1% sequence similarity). The whole-genome sequencing of strain CJ43T was performed using the PacBio RS II platform, revealing a genome size of 3.9 Mb in a single contig with DNA G+C content of 34.9%. The genome included 3144 predicted protein-coding genes, as well as 55 tRNA, 9 rRNA and 3 ncRNA genes. The genome also contained 92 putative antibiotic resistance genes, reflecting its phenotypes. The average nucleotide identity and in silico digital DNA-DNA hybridization values between strain CJ43T and P. glucosidilyticus 1-2T were 88.7%, and 38.6%, respectively. The major fatty acids of strain CJ43T were iso-C15:0, iso-C17:0 3-OH, and summed feature 3 (C16:1 ω6c and/or C16:1 ω7c). Strain CJ43T contained phosphatidylethanolamine as a major polar lipid and menaquinone-7 as a sole respiratory quinone. Based on the polyphasic taxonomy data, strain CJ43T represents a novel species of the genus Pedobacter, for which the name Pedobacter aquae sp. nov. is proposed with the type strain CJ43T (= KACC 21350T = JCM 33709T).
Commissioning Measurements On An Elekta Unity MR-Linac
Authors: Powers Marcus , Baines John , Crane Robert , Fisher Chantelle , Gibson Stephen , Marsh Linda , Shirley Bronwyn , Shoobridge Ariadne , Walt Marchant Van der , de Vine Glenn
Published: September 2021

MR-guided radiotherapy technology is relatively new and commissioning publications, QA protocols and commercial products are limited. This work provides guidance for implementation measurements that may be performed on the Elekta Unity MR-Linac (Elekta, Stockholm, Sweden). Adaptions of vendor supplied phantoms facilitated determination of gantry angle accuracy and MV isocentre, whereas in-house developed phantoms were used for End-to-End (E2E) testing and anterior coil attenuation measurements. Third-party devices were used for measuring beam quality, reference dosimetry and during IMRT commissioning; however, due to several challenges, variations on standard techniques were required. Gantry angle accuracy was within 0.1°, confirmed with pixel intensity profiles, and MV isocentre diameter was < 0.5 mm. Anterior coil attenuation was < 0.6 %. Beam quality as determined by TPR20,10 was 0.704 ± 0.002, in agreement with treatment planning system (TPS) calculations, and gamma comparison against the TPS for a 22.0 × 22.0 cm2 field was above 95.0 % (2.0 %, 2.0 mm). G90 output was 1.000 ± 0.002 Gy per 100 MU, depth 5.0 cm. During IMRT commissioning, sub-standard results indicated issues with machine behaviour. Once rectified, gamma comparisons were above 95.0 % (2.0 %, 2.0 mm). Centres which may not have access to specialized equipment can use in-house developed phantoms, or adapt those supplied by the vendor, to perform commissioning work and confirm operation of the MRL within published tolerances. The IMRT QA devices and techniques used in this work highlight issues with machine behaviour when appropriate gamma criteria are set.
The Energy Consumption-Environmental Quality Nexus in BRICS Countries: The Role of Outward Foreign Direct Investment (OFDI)
Authors: Mohanty Saileja , Sethi Narayan
Published: September 2021

This paper examines the role of outward foreign direct investment (OFDI) on energy consumption and environmental quality in BRICS from 1990 to 2019. We use cross-sectional dependence (CSD) and the Pesaran-Yamagata slope homogeneity for the diagnostic test. After confirming the diagnosis test, we employ CIPS and CADF second generation panel unit root test, which confirms that all elements are stationary at first difference. The Pooled Mean Group (PMG), Westerlund cointegration, two-step GMM, panel FMOLS and DOLS model have been used to determine the short term and long-term association among the variables. The cointegration and PMG results confirm that the short-run and long-run association exists among the considered variables. The GMM and DOLS results reveal that developing countries produced environmental pollution at the early stage of development and checked in the long run. The empirical results hold up the EKC hypothesis, which implies that OFDI and energy consumption help expand greener technology to host countries' environmental improvement in the long run and confirm that an inverted U-shaped linkage exists. Hence, the study suggests that developing countries should pay more attention to sustainable development and technological development that encourages more eco-friendly and environment-friendly technology. To frame the profitable strategies, governments of emerging countries should inspire public-private partnerships to circulate the environmental consciousness, guideline for energy efficiency, and generate a pollution-free environment.
Pharmacological Rescue with SR8278, A Circadian Nuclear Receptor REV-ERBα Antagonist as a Therapy for Mood Disorders in Parkinson’s Disease
Authors: Kim Kyungjin , Kim Jeongah , Park Inah , Jang Sangwon , Choi Mijung , Kim Doyeon , Sun Woong , Choe Youngshik , Choi Ji-Woong , Moon Cheil , Park Sung Ho , Choe Han Kyoung
Published: September 2021

Background: Parkinson’s disease is a neurodegenerative disease characterized by progressive dopaminergic (DAergic) neuronal loss. Motor deficits experienced by patients with Parkinson’s disease are well documented, but non-motor symptoms, including mood disorders associated with circadian disturbances, are also frequent features. One common phenomenon is “sundowning syndrome,” which is characterized by the occurrence of neuropsychiatric symptoms at a specific time (dusk), causing severe quality of life challenges. This study aimed to elucidate the underlying mechanisms of sundowning syndrome in Parkinson’s disease and their molecular links with the circadian clock.Methods: To induce the Parkinson’s disease mouse model, a single injection of 6-hydroxydopamine (6-OHDA) was administered into the left dorsal striatum. Five weeks post injection, mood-related behavioral tests were performed at the indicated time of day (circadian time 22-01 vs. 10-13). Local injection of a REV-ERBα antagonist, SR8278, into the ventral tegmental area, was performed 3 h before each behavioral test. To determine the molecular mechanism of behavioral deficits, fluorescent in situ hybridization, chromatin immunoprecipitation assay, western blot analysis, and ATAC-sequencing were performed.Results: Our study demonstrated that 6-OHDA-lesioned mice exhibited increased depression- and anxiety-like behaviors only at dawn. SR8278 treatment exerted antidepressant and anxiolytic effects in a circadian time-dependent manner in 6-OHDA-lesioned mice, restoring the circadian rhythm of mood-related behaviors. 6-OHDA-lesion altered DAergic-specific Rev-erbα and Nurr1 transcription, and atypical binding activities of REV-ERBα and NURR1, which are upstream nuclear receptors for the discrete tyrosine hydroxylase promoter region SR8278, restored the binding activities of REV-ERBα and NURR1 to the tyrosine hydroxylase promoter and the induction of enrichment of the R/N motif, recognized by REV-ERBα and NURR1 only at dawn, as revealed by ATAC-sequencing; therefore, tyrosine hydroxylase expression was elevated in the ventral tegmental area of 6-OHDA-injected mice, especially at dawn.Conclusions: These results indicate that REV-ERBα is a potential therapeutic target, and its antagonist, SR8278, is a potential drug for mood disorders related to circadian disturbances, namely sundowning syndrome, in Parkinson’s disease.
ScanNet: An interpretable geometric deep learning model for structure-based protein binding site prediction
Authors: Tubiana Jérôme , Schneidman-Duhovny Dina , Wolfson Haim
Published: September 2021

Predicting the functional sites of a protein from its structure, such as the binding sites of small molecules, other proteins or antibodies sheds light on its function in vivo. Currently, two classes of methods prevail: Machine Learning (ML) models built on top of handcrafted features and comparative modeling. They are respectively limited by the expressivity of the handcrafted features and the availability of similar proteins. Here, we introduce ScanNet, an end-to-end, interpretable geometric deep learning model that learns features directly from 3D structures. ScanNet builds representations of atoms and amino acids based on the spatio-chemical arrangement of their neighbors. We train ScanNet for detecting protein-protein and protein-antibody binding sites, demonstrate its accuracy - including for unseen protein folds - and interpret the filters learned. Finally, we predict epitopes of the SARS-CoV-2 spike protein, validating known antigenic regions and predicting previously uncharacterized ones. Overall, ScanNet is a versatile, powerful, and interpretable model suitable for functional site prediction tasks. A webserver for ScanNet is available from http://bioinfo3d.cs.tau.ac.il/ScanNet/
High-Solid Loading Enzymatic Hydrolysis of Waste Office Paper for Poly-3-Hydroxybutyrate Production Through Simultaneous Saccharification and Fermentation
Authors: Al-Battashi Huda , Sivakumar Nallusamy
Published: September 2021

Waste paper holds great potential as a substrate for the microbial production of bioplastic (Poly-3-hydroxybutyrate (PHB)). This study aimed to produce PHB by utilizing office paper as a substrate using Cupriavidus necator through batch and fed-batch simultaneous saccharification and fermentation (SSF) approach. For the batch experiment, different loadings of shredded office paper (3, 5 and 10%) with two different pretreatments H2O2 (OPH) and H2O2 and Triton X-100 (OPTH) were carried out. For the fed-batch experiment, paper loading started with 3% and two more additions were made at 36 and 84 h. Both experiments were conducted at 30°C, 200 rpm and pH 7 using 55.5 FPU/g of cellulase and 37.5 CBU/g of β-glucosidase with a fixed amount of nitrogen source. High PHB yield was observed with OPH in all loadings, though the OPHT showed a better hydrolysis. Maximum PHB yield (4.27 g/L) was achieved with 10% OP at six days of fermentation in batch SSF. Whereas, maximum PHB yield (4.19 g/L) was obtained within a shorter time (66 h) in the fed-batch OPH paper. The extracted PHB showed well-matched characteristic features to the standard PHB. Finally, this study proves the feasibility of employing SSF process for PHB production using waste paper as an alternative approach to overcome the shortcoming of the separate hydrolysis and fermentation (SHF) process.
Effectiveness of Predicting The Spatial Distributions of Target Contaminants of a Coking Plant Based On Their Related Pollutants
Authors: Qiao Pengwei , Lai Donglin , Yang Sucai , Zhao Qianyun , Wang Hengqin
Published: September 2021

The prediction accuracy of the spatial distribution of soil pollutants at a site is relatively low. Related pollutants can be used as auxiliary variables to improve the prediction accuracy. However, little relevant research has been conducted on site soil pollution. To analyze the prediction accuracy of target pollutants combined with auxiliary pollutants, Cu, toluene, and phenanthrene were selected as the target pollutants for this study. Based on geostatistical analysis and spatial analysis, the following results were obtained. (1) The reduction rate of the root mean square errors (RMSEs) for Cu, toluene, and phenanthrene with multivariable cokriging were 68.4%, 81.6%, and 81.2%, respectively, which are proportional to the correlation coefficient of the relationship between the auxiliary pollutants and the target pollutants. (2) The predicted results for Cu, phenanthrene, and toluene and their corresponding related pollutants are more accurate than the results obtained not using the related pollutants. (3) In the interpolation process, the RMSEs for Cu, toluene, and phenanthrene with multivariable cokriging basically increase as the neighborhood sample data increases, and then they become stable. (4) When 84, 61, and 34 sample points were removed, the RMSEs for Cu, toluene, and phenanthrene, respectively with multivariable cokriging were close to the RMSEs of the target pollutants based on the total samples. The results are of great significance to improving the prediction accuracy of the spatial distribution of soil pollutants at coking plant sites.
Genetic Analysis And Traits Association Study In Marker-Assisted Multi-Drought-Traits Pyramided Genotypes Under Reproductive-Stage Moisture Stress In Rice (Oryza Sativa L.)
Authors: Katral Ashvinkumar , Biradar Hanamareddy , Harijan Yallappa , R. Aruna Y. , Hadimani Jagadeesh , Hittalmani Shailaja
Published: September 2021

Reproductive-stage drought-stress is a major production constraint in rainfed rice ecosystem. Emergence of marker-assisted breeding strategies for developing drought-tolerant rice varieties are being optimized through exploiting adaptive-traits for their increased contribution towards grain-yield under recurring-drought. Grain-yield is a complex-trait; requires knowledge of genetics and association among yield contributing component-traits. Current study was undertaken using 21 marker-assisted multi-drought-traits pyramided genotypes responses for genetic variability and association of traits for grain-yield under aerobic and reproductive-stage drought conditions. Field evaluation was carried-out in two seasons and data was collected on various parameters. Path-coefficient analysis was used as a selection criterion to select yield contributing-traits and found nine phenotypic traits were having a positive direct-effect on grain-yield during both and/or at least one season under both moisture-regimes. The data from summer and Kharif seasons have been pooled within their respective moisture-regimes due to the non-significance of Levene’s test of homogeneity of variances and estimated BLUP values. ANOVA based on BLUP values revealed significant differences for moisture-conditions and also among genotypes. Phenotypic variation via. box-plots and histogram depicted mean phenotypic differences of traits under two moisture-regimes. Majority of the traits possessed high PCV and GCV with high heritability and GAM indicating higher trait expression and additive gene action lead to effectiveness of selection under drought/moisture stress. Grain-yield possessed a positive correlation with all the component-traits under consideration during both moisture-regimes. Selection of genotypes based on these component-traits were rewarding and seems to be better selection-criteria. Finally, we can end-up with superior-genotypes suitable for intermittent-drought conditions.