bluuebunny/crossref_metadata_2025 huggingface dataset:
Alpha toxin production potential and antibiotic resistance patterns of clostridium perfringens isolates from meat samples
Authors: Ali Tehreem , Sarwar Arslan , Anjum Aftab Ahmad
Published: June 2024

Objective: This research aimed to analyze the prevalence, molecular characteristics, toxinotyping, alpha toxin production potential, and antibiotic resistance pattern of Clostridium perfringens (C. perfringens) isolates in meat samples collected from various sources.Methods: Sixty meat samples were screened for alpha toxin using enzyme-linked immunosorbent assay, revealing a positivity rate of 13.3%, predominantly in raw poultry meat. Subsequent culturing on Perfringens agar identified nine samples harboring characteristic C. perfringens colonies, primarily isolated from raw poultry meat. Molecular confirmation through 16S rRNA gene amplification and sequencing authenticated twelve isolates as C. perfringens, with nine strains exhibiting genetic resemblance to locally isolated strains. Toxinotyping assays targeting alpha toxin-specific genes confirmed all nine isolates as type A C. perfringens, with no detection of beta or epsilon toxin genes. Hemolytic assays demonstrated varying alpha toxin production potentials among isolates, with accession number OQ721004.1 displaying the highest production capacity. Moreover, antibiotic resistance profiling revealed multi-drug resistance patterns among the isolates.Results: The study identified distinct clusters within C. perfringens strains, indicating variations. Phylogenetic analysis delineated genetic relatedness among strains, elucidating potential evolutionary paths and divergences.Conclusion: The findings underscore the need for robust surveillance and control measures to mitigate the risk of C. perfringens contamination in meat products, particularly in raw poultry meat. Enhanced monitoring and prudent antimicrobial stewardship practices are warranted in both veterinary and clinical settings to address the observed antibiotic resistance profiles and prevent foodborne outbreaks.
Genome-wide association study comparison analysis based on Hanwoo full-sib family
Authors: Kim Ji-Yeong , Kim Eun-Ho , Kang Ho-Chan , Myung Cheol-Hyun , Kong Il-Keun , Lim Hyun-Tae
Published: June 2024

Objective: The improvement of carcass traits is essential for the Hanwoo industry because of the Hanwoo grade determination system, and genome-wide association study (GWAS) analysis is an instrumental tool for identifying the genetic factors that impact these traits. While GWAS analysis utilizing family data offers advantages in minimizing genetic bias, research on family-based GWAS in Hanwoo is currently lacking.Methods: This study classified Group A using both parental and offspring genetic information, and Group B based solely on offspring genetic information, to compare GWAS analysis results of Hanwoo carcass traits.Results: A total of 16 significant single nucleotide polymorphism (SNP) markers were identified in Group A, comprising 7 for carcass weight (CWT), 3 for back fat thickness (BFT), and 6 for marbling score (MS). In Group B, 7 significant SNP markers were identified, including 3 for CWT, 1 for eye muscle area, 1 for BFT, and 2 for MS. Functional annotation analysis revealed only one common function related to carcass traits between the groups, while protein-protein interaction analysis indicated more gene interactions in Group A. The reliability of estimated values for common SNP markers identified between the groups was higher in Group A.Conclusion: GWAS analysis utilizing parental genetic information holds greater potential for application, owing to its higher reliability of estimated values and the ability to explore numerous candidate genes.
O ENSINO DE LÍNGUA PORTUGUESA PARA ESTRANGEIROS (PLE):
Authors: Barros Ev' Ângela Batista Rodrigues de , Carvalho Valquíria Carolina Pimentel Sales de , Santos Leticia Costa Silveira
Published: June 2024

Neste trabalho, apresentamos, de forma reflexiva, uma experiência de ensino de PLE a intercambistas de uma universidade confessional mineira, no bojo de um projeto que congrega ensino a extensão e pesquisa. Norteadas pelo aporte teórico de cunho sociointeracionista (BAKHTIN, 2019; VOLÓCHINOV, 2018), sociolinguístico (BAGNO, 2007) e cognitivo-funcional (MARTELOTTA, 2011), nos dedicamos à análise de material didático disponível, à produção customizada de unidades didáticas e jogos (virtuais e de tabuleiro), visando a aprimorar estratégias pedagógicas que vimos adotando, sobretudo após o retorno pós-pandemia. Numa modalidade marcada pela heterogeneidade e pelo trabalho com pequenos grupos, optamos pelo uso de material lúdico, com o foco no ensino de articuladores textuais e expressões idiomáticas, em que usualmente há maior dificuldade de aprendizagem. O feedback dos alunos evidencia que esta estratégia se mostrou pertinente como auxiliar no desenvolvimento de competências linguísticas importantes de escrita e de oralidade.
A ELABORAÇÃO E O USO DE HISTÓRIAS EM QUADRINHOS NO PROCESSO DE ENSINO-APRENDIZAGEM DO ENSINO DE QUÍMICA
Authors: Maia Paulo José de Sousa , Silva Matheus Gomes da , Costa Alan Mendonça
Published: June 2024

O modelo de ensino baseado na metodologia expositiva não tem se mostrado eficaz. Por esta razão, alternativas metodológicas têm sido propostas para favorecerem o ensino e a aprendizagem, tais como as que fazem uso de histórias em quadrinhos. Este estudo tem como foco o ensino das ciências naturais por meio da utilização de histórias em quadrinhos sobre conteúdos de Energia e Matéria. Um estudo de caso de natureza qualitativa foi realizado no Colégio de Aplicação de Macaé, RJ, Brasil, onde propôs-se atividades de ensino e aprendizagem realizadas em quatro aulas de 50 minutos, com 21 estudantes de duas turmas da 1ª série do Ensino Médio. Os estudantes participantes responderam a questionários pré e pós-intervenção sobre os conceitos científicos abordados nas atividades e a questão social. O pré-teste foi aplicado para entender a habilidade básica dos estudantes em leitura e o pós-teste para avaliar utilização do HQs como material didático. A análise dos dados coletados sugere que os métodos de ensino e aprendizagem empregados nesta pesquisa são uma forma viável de ensinar as ciências naturais de maneira contextualizada.  A ferramenta didática escolhida obteve aprovação entre os estudantes, sendo, tendo em vista que 76,2% dos estudantes assimilaram tal abordagem como interessante e os outros 23,8% estudantes afirmam ter sido uma experiência legal.
RELAÇÕES ÉTNICO-RACIAIS NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL:
Authors: Braz Wilson Rodrigues , Barros Reyssila Rute da Silva , Sousa Denisse Aparecida dos Santos
Published: June 2024

A Lei nº 10.639/2003 estabelece as diretrizes e bases da educação nacional com a obrigatoriedade da temática “História e Cultura Afro-brasileira”. As relações étnico-raciais necessitam ser debatidas no meio educacional, sobretudo para o Ensino Fundamental, que ainda encontra lacunas na efetivação nos currículos escolares e na prática pedagógica sobre a temática. Portanto, os objetivos deste trabalho foram investigar como a abordagem das relações étnico-raciais nos anos iniciais do Ensino Fundamental ocorreram no contexto escolar na última década e compreender a sua correlação com os documentos norteadores para o ensino da temática, bem como discutir sua importância no contexto formador humano. Foi realizada uma pesquisa qualitativa, de natureza básica, explorando o tema a partir de um levantamento bibliográfico no portal CAPES e utilizando como descritores e operador booleano: “étnico-raciais” AND “ensino” AND “anos iniciais”. Quanto aos critérios de inclusão, buscaram-se artigos em língua portuguesa (variante brasileira) envolvendo a temática e publicados no período de 2013 a 2023. A análise de dados se baseou na teoria histórico-cultural. Como resultados, os dados revelaram que os professores buscam ensinar a temática das relações étnico-raciais na escola de forma diversificada. Porém, são os docentes que precisam tomar a iniciativa de preparo da temática para as aulas, pesquisando mais profundamente sobre o conteúdo a fim de atender à legislação vigente.
A EDUCAÇÃO INCLUSIVA NA EDUCAÇÃO INFANTIL E A GESTÃO ESCOLAR:
Authors: Reis Renata Lima Durães , Duarte Leonardo Felipe Gonçalves , Martins Ida Carneiro
Published: June 2024

Um dos desafios da gestão educacional é oferecer subsídios para a oferta da educação inclusiva nas escolas regulares. Impeditivos como falta de infraestrutura, formação de professores e recursos financeiros são evidentes, dificuldades diante de um cenário que anseia pela inclusão. Observando tal condição, a pesquisa teve por objetivo realizar uma revisão de literatura para verificar o estado atual do conhecimento sobre o tema de educação inclusiva e a gestão escolar. Para tanto realizou-se a busca por artigos em na Scientific Electronic Library Online - Scielo uma das principais bases de dados que foi a Scielo e por dissertações e teses na Biblioteca Digital de Teses e Dissertações – BDTD, por meio de descritores previamente estabelecidos. Como resultados que emergiram da pesquisa identificou-se que as produções encontradas davam maior destaque às necessidades formativas dos gestores para a implementação de escolas inclusivas para bebês e crianças pequenas com deficiência em instituições de Educação Infantil, bem como que existe a necessidade de haver maior compreensão dos documentos para a oferta uma educação inclusiva de qualidade.
A DOCÊNCIA NA ENGENHARIA AGRONÔMICA:
Authors: Uchôas Danielle , Guimarães Lucélia Tavares
Published: June 2024

Neste artigo apresentam-se os resultados finais da pesquisa de mestrado que tratou o trabalho docente exercido por mulheres formadas em engenharia agronômica tendo como referencial teórico Karl Marx, Heleieth Saffioti e Helena Hirata. Se por um lado, a masculinização da engenharia sobressalta a divisão sexual do trabalho, por outro lado, a feminização da docência faz com que se tenha a falsa impressão de que em tal profissão não exista divisão sexual do trabalho. Além da fundamentação teórica e da revisão bibliográfica, entrevistou-se as docentes do curso de Engenharia Agronômica da Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP). Concluiu-se que as mulheres, embora venham conquistando espaços cada vez maiores na Engenharia Agronômica, ainda precisam vencer muitos obstáculos devido ao seu gênero. Outrossim, à docência embora seja uma profissão feminilizada, observou-se reflexos da divisão sexual do trabalho que corroboram com a teoria do Teto de Vidro.
Der globale Klimawandel wird „nicht in Duisburg entschieden“: Eine exemplarische Untersuchung von Frames von Lokaljournalist*innen und möglichen Kontextfaktoren
Authors: Jörges Susan , Guenther Lars , Brüggemann Michael
Published: June 2024

In der Klimakommunikation sind Frames im Lokaljournalismus ein relevanter und doch selten untersuchter Forschungsgegenstand. Solche Frames haben einen Einfluss auf den Umgang mit dem Klimawandel, auf Problembewusstsein und Verhaltensweisen von Bürger*innen und auf lokale Klimapolitik. Hinter Frames in der lokalen ­Berichterstattung stehen die Framing-Praktiken von Lokaljournalist*innen, die anhand ihrer kognitiven Frames sowie individuellen und redaktionellen Kontextfaktoren das lokale, mediale Bild des Klimawandels prägen. Mittels qualitativer Interviews mit zehn Lokaljournalist*innen verschiedener Regionen Deutschlands rekonstruiert dieser Beitrag drei kognitive Frames von Lokaljournalist*innen und exploriert ihren Zusammenhang mit weiteren Kontextfaktoren. Die Frames unterscheiden sich besonders bezüglich ihrer ­Lösungsorientierung und vor allem in deren Progressivität. Das Frame-Set der Lokal­jour­na­list*innen steht zudem in einem besonderen Zusammenhang mit den verfügbaren redaktionellen Ressourcen. Der Beitrag reflektiert diese Befunde für die Klimakommunikation und leitet Implikationen für die lokale, journalistische Praxis ab.
Role of Metabolomics in Precision Medicine in the Context of Systemic Lupus Erythematosus and Lupus Nephritis
Authors: Rojo-Sánchez Alejandra , Abuchaibe Agustín , Carmona Ada , Arrieta-Bravo Valentina , Chica-Valle David , Díaz-Olmos Yirys , Pacheco-Lugo Lisandro
Published: June 2024

Systemic lupus erythematosus (SLE) is an autoimmune, multisystemic disease, the underlying causes of which are not fully understood. Clinically, SLE is a heterogeneous disease, and its clinical spectrum overlaps with other rheumatic diseases. Even though multiple organs can be involved in the progression of the disease, the kidney is the main indicator of morbidity and mortality in SLE, a condition known as lupus nephritis (LN). The diagnosis of LN still requires an invasive procedure that becomes impractical when monitoring patients with a confirmed diagnosis, and the described biomarkers do not meet the characteristics of a good biomarker. Recently, “omics” technologies have revolutionized the field of the molecular diagnosis, including autoimmune diseases. Metabolomics has been an extremely useful tool for identifying non-invasive biomarkers in the clinical context and is proposed as a powerful and promising tool to differentiate between individuals with SLE without renal damage and patients with SLE with renal involvement. In addition, this methodology will allow the categorization of patients according to renal damage, promising personalized management of LN in the context of SLE. Here, we review the potential of untargeted metabolomic approaches using LC/GC-MS and MNR to identify potential biomarkers for renal damage in patients with SLE.
Pengaruh Metode Pembelajaran Digital Mind Mapping dalam Meningkatkan Kemampuan Tata Bahasa Korea Tingkat Dasar: -고, -거나, -지만, -(으)ㄴ/는데
Authors: Jaya Cynthia Calista , Triarisanti Risa , Azizah Asma
Published: June 2024

Tata bahasa merupakan hal yang utama dalam pembelajaran bahasa Korea. Penggunaan metode pembelajaran juga berlaku dalam konteks pembelajaran tata bahasa Korea, yang memiliki perbedaan mendasar dengan tata bahasa Indonesia. Karena perbedaan yang signifikan, muncul fenomena bahwa pemelajar Indonesia yang belajar bahasa Korea sering menghadapi kesulitan dan membuat kesalahan dalam penggunaan tata bahasa. Salah satu metode pembelajaran yang dapat dimanfaatkan untuk membantu mengatasi fenomena tersebut adalah digital mind mapping. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh digital mind mapping terhadap peningkatan kemampuan tata bahasa Korea tingkat dasar. Metode yang digunakan dalam penelitian ini yaitu metode kuantitatif dengan desain pre-experimental one group pretest-posttest design. Penelitian dilaksanakan di SMAK 2 BPK Penabur Bandung dengan sampel sebanyak 28 orang peserta didik kelas 12 yang mengambil mata pelajaran tambahan bahasa Korea. Hasil dari penelitian ini menunjukkan adanya peningkatan kemampuan tata bahasa Korea tingkat dasar peserta didik, berdasarkan rata-rata nilai pre-test sebesar 43,82 dan tergolong ke dalam kriteria ‘kurang’ dan meningkat berdasarkan rata-rata nilai post-test sebesar 70,25 dan tergolong ke dalam kriteria ‘baik’. Hasil uji T menunjukkan nilai thitung lebih besar daripada nilai ttabel (5,85 > 2,05), maka hipotesis alternatif diterima dan hipotesis null ditolak, sehingga dapat disimpulkan bahwa terdapat pengaruh dari penggunaan digital mind mapping terhadap kemampuan tata bahasa Korea tingkat dasar peserta didik. Hasil analisa angket menunjukkan respons positif dari peserta didik terhadap metode mind mapping dalam pembelajaran tata bahasa Korea. Kesimpulan yang dapat ditarik dari penelitian ini adalah digital mind mapping dapat digunakan sebagai metode pembelajaran untuk meningkatkan kemampuan tata bahasa Korea tingkat dasar.
Representasi Bushido Tokoh Madenokoji Arikoto dalam Anime “Ooku”
Authors: Isnaini Siti Nur , Sunarni Ani , Hamidah Aam
Published: June 2024

Penelitian ini meneliti representasi nilai Bushido pada tokoh Madenokoji Arikoto yang terdapat pada anime “Ooku”. Tujuan penelitian ini adalah mencari gambaran tujuh nilai Bushido pada tokoh Arikoto. Penelitian ini menggunakan metode deskriptif kualitatif dengan pendekatan analisis semiotika Rolland Barthes. Pengumpulan data dilakukan dengan teknik simak bebas libat cakap. Teori yang digunakan adalah nilai Bushido yang dicetuskan oleh Inazo Nitobe. Berdasarkan hasil penelitian diperoleh 18 data yang merepresentasikan nilai bushido pada diri Arikoto, yaitu nilai Yuu (勇) sebanyak 2 data, nilai Jin (仁) sebanyak 10 data, nilai Rei (霊) terdapat 2 data, nilai makoto (誠) ada 2 data, meiyo (名誉) berjumlah 2 data dan Chuugi (忠義) dan gi sebanyak 1 data, dan terdapat satu data dengan dua nilai yaitu Yuu dan Jin.
Use of Drilling Method to Improve Students’ Vocabulary Mastery
Authors: Siahaan Annatalia , Setiawan Wawan , Surista Ade
Published: June 2024

This research focused on applying the drilling method to improve students’ vocabulary mastery at HKBP Kompas Indah. The drilling method is a method carried out by the teachers so that students can remember the new language items they have learned. With a quantitative approach and experimental research design, the researchers used pre-tests and post-tests. The participants involved were divided into control group and experimental group. The results showed that there was a significant increase in the pre-test and post-test scores in the experimental group. In contrast, the scores in control group had a decline from pre-test to post test. The mean score of post-test experimental group (89) was higher than pre- test experimental group (74). Therefore, the drilling method was effective to improve students’ vocabulary mastery at Sunday school HKBP Kompas Indah.
Strategi Guru Pendidikan Agama Islam Mengembangkan Kompetensi Sikap Spiritual Dan Sikap Sosial Siswa
Authors: Wati Veranda  , Subhan  , Muh.Yamin
Published: June 2024

This study discusses the Strategy of Islamic Religious Education Teachers in developing Spiritual and social attitudes competencies of students at SDN 381 Kanan Kab. Luwu. This study aims: To know the condition of the spiritual and social attitudes of students in Elementary School 381 Kanan, to describe the strategy of Islamic religious education teachers in developing the competence of spiritual attitudes and social attitudes of students at SDN 381 Kanan Kab. Luwu and to describe the obstacles faced by Islamic religious education teachers in developing the competence of spiritual attitudes and social attitudes of students at SDN 381 Kanan Kab. Luwu. This research uses a qualitative approach with field researh methods. Data collection techniques use observation, interview and documentation methods. This study shows that: the problems that exist in students' attitudes are that there is still bullying between students in the class, not being serious while attending lessons, not respecting teachers and throwing rubbish carelessly; and then the strategy of Islamic religious education teachers in developing the competence of spiritual attitudes and social attitudes of students at SDN 381 Kanan Kab. Luwu namely showing a good example, providing direction/guidance providing, providing encouragement /motivation, and giving punishment to student who violate.
Tantangan dan Hambatan dalam Menjalankan Peran Khalifah: Studi Kasus Dalam Lingkup Mahasiswa UPN Veteran Jawa Timur
Authors: Dewi Dewi Nuriatul Jannah , A. Muammar Alawi  , Sri Defiana Putri  , Rizky Amalia Khusna
Published: June 2024

Islam is a religion that is much sought after by the world's population. Humans as noble and special creatures are an inseparable part of this universe, so Allah SWT has given them various advantages compared to other creatures. The role of humans on earth as caliphs or as leaders on earth is a very strategic role. Challenges and obstacles in carrying out the role of caliph among UPN Veteran East Java students were analyzed using a questionnaire method, data was collected from 50 students to gain in-depth insight into their views on the role and obstacles as caliph in the campus environment. The research results show that the majority of UPN Veteran East Java students have a positive view of the role of the caliph, with 66.3% agreeing or strongly agreeing. As many as 80% of students felt that their friends' views were also very positive, indicating strong social support. However, 58.3% of students admitted that there were challenges and obstacles in carrying out the role of caliph on campus. Strong social support is considered important to overcome the challenges faced in the Industrial Revolution 4.0 era, in line with research which shows that rapid changes in this era require special attention to character education.
Keywords: Islamic Religious Education, Khalifah, Questionnaire
Use of Ice Cream Stick Props to Improve Mathematics Learning Outcomes Addition and Subtraction Material For Grade I Students of MI Hidayatul Mubtadiin New
Authors: Samirih Samirih
Published: June 2024

The background of this research was – low mathematics calculation operations, addition, and subtraction in mathematics subjects found in the learners at Islamic Primary School Hidayatul Mubtadiin New Kedungwungu. This Classroom Action Research applied the Kemmis & Taggar model, starting from planning, acting, observing, and reflecting to improve the mathematics learning outcomes of the learners. The population consisted of first graders of Islamic Primary School Hidayatul Mubtadiin New who could not do addition and subtraction operations. The population also became the research sample that received mathematics learning with ice cream stick properties for three cycles. The researchers collected the data using Observation, tests, documentation, and interviews to analyze descriptively. The results showed increased learning outcomes for the learners after using the ice cream stick property for learning mathematics within the materials of addition and subtraction. The results showed that the learners could reach the minimum mastery completion on each cycle. In cycle I, six learners, or 30% of learners, passed the minimum completion. In cycle II, the numbers increased to 13 learners, 65%. Then, in cycle III, the numbers improved to 17 learners, 85%. From the results, the researchers suggested schools provide proper property facilities and infrastructure for the teachers. The researchers also recommend that teachers apply the ice cream stick property to mathematics learning. The teachers must also consider the learners' skills.
Dijital Sosyal Kimlik Oluşumunda Sosyal Medya Kullanımının Etkileri ve Dinamikleri
Authors: Summak Mehmet Erhan
Published: June 2024

Bu çalışma da, dijital çağın gelişimiyle birlikte sosyal medya platformlarının insanların sosyal kimliklerini oluşturma ve ifade etme süreçlerindeki rolü incelenmiştir. Sosyal medya, bireylerin dijital ortamdaki kimliklerini şekillendirme sürecinde kritik bir araçtır. Özellikle çevrimiçi etkileşimlerin, insanların kendilerini nasıl gördüklerini ve diğerlerini nasıl algıladıklarını belirlemede önemli bir rol oynamaktadır. Ayrıca çalışmada, arkadaşlık ağlarının ve içerik yönetiminin çevrimiçi kimliklerin oluşumunda ve şekillendirilmesinde önemli olduğu vurgulanmıştır. Arkadaşlar ve takipçiler, kullanıcıların çevrimiçi varlıklarını düzenlemelerinde etkili olurken, içerik paylaşımı da sosyal onay arayışını etkilemektedir. Bununla birlikte, sosyal medyadaki karşılaştırma ve rekabet gibi faktörlerin, bireylerin benlik saygısı üzerinde olumsuz etkilere yol açabileceği ve tutarlı bir çevrimiçi kimlik sunumunu sağlamak için zorlu bir süreçle karşılaşılabileceğini vurgulamaktadır.
Gizliliğin ve anonimliğin de çevrimiçi kimliklerin oluşturulması sürecinde önemli bir rol oynadığı anlaşılmaktadır. Gerçek isim kullanımı ile anonimlik arasında bir denge kurmanın mümkün olduğu ve sosyal medya platformlarının gizlilik ayarlarının, kullanıcıların çevrimiçi varlıklarını düzenlemelerine yardımcı olabileceği görülmüştür. Ancak bu süreçte kullanıcıların içsel ve dışsal baskılarla karşılaşabileceği ve çevrimiçi kimliklerinin karmaşıklığında gezinmek zorunda kalabilecekleri de bir gerçekliktir. Ayrıca çalışmada sosyal medyanın sosyal kimlik üzerindeki olumsuz etkileri de ele alınmıştır. Sosyal medyanın yaygınlaşmasıyla birlikte, bazı olumsuz etkilerin ortaya çıktığı ve bu etkilerin kullanıcıların yaşadığı stres ve kaygıları artırabileceği vurgulanmıştır. Bu noktaları göz önünde bulundurarak, dijital platformlarda sosyal kimliğin geleceği üzerine yapılan tartışmaların önemine de dikkat çekilmiştir. Bu bağlamda, sosyal medyanın insanların sosyal kimlikleri üzerindeki etkilerini anlamak ve bu etkilerle başa çıkmak için daha fazla araştırmaya ihtiyaç duyulmaktadır.
Hematological And Hemostasis Profile, Thrombotic Risk In Sickle Cell Patient In Cameroon : An Analytical Cross-Sectional Study
Authors:   Higher Institute of Health Sciences: Université des Montagnes, Bangangté, West-Cameroon
Published: June 2024

Background : Thrombosis is a disease characterized by the formation of blood clots inside the vessels. It is a situation commonly encountered during certain pathologies in general and sickle cell disease in particular during which it is associated with a very high risk of ischemic stroke. The purpose of this study is to determine the profile of blood count and thrombotic risk in sickle cell patients. Methodology : We conducted an analytical cross-sectional study at the Bafoussam Regional Hospital over 03 months. The study population consisted of consecutively recruited homozygous sickle cell and sickle cell traits. Blood samples from the latter were collected and sent to the laboratory for the completion of the blood count and hemostasis profile. The results obtained were analyzed using statistical software R version 4.1.1. Univariate logistic regression analyses were used to identify factors associated with thrombotic risk in our study population. Results : The size of our population was 148 patients including 80 sickle cell patients and 68 with sickle cell trait AS. The frequency of thrombotic risk in the population was 35.1% with 52,5% in SS and 14.7%% in AS (p=0.002). The mean fibrinogen in SS and AS was 5.32±0.50 g/L and 4.63±0.00 g/L respectively (p<0.001). The mean Quick Time was 11.8±1.94 s for SS and 12.2±2.72 s for AS (p=0.336). The mean cephalin time and activator were 23.3±5.90 s for SS and 24.3±7.89 s for AS with and (p=0.395), respectively. The mean D-dimer in SS was 1.88±2.09 mg/L and 1.12±2.40 mg/L in AS (p=0.045). The mean hemoglobin in SS was 7.13±1.41 g/dL and in AS was 14.4±2.57 g/dL (p<0.001). Thrombocytosis is positively associated with thrombotic risk (Or = 2.52, 95% CI = [1.13; 5.63] ; (p=0.022)). Moreover, ‘AS’ status is beneficial for the occurrence of thrombotic risk unlike SS (Or = 0.16, 95% CI = [0.07; 0.35]; (p=0.001). In addition, elevated fibrinogen is a risk factor for thrombotic risk (OR=2.50, 95% CI = [4.99; 1.25]; p=0.009). Conclusion : Given the weight of sickle cell disease and its complex pathophysiology, knowledge, and understanding of thrombotic risk is imperative to guide therapeutic strategies in the management and clinical management of patients. These data highlight the need for regular and systematic hemostasis assessment in sickle cell patients to prevent possible risks of thrombosis.
Seed morphology of the paleotropical tribe Paropsieae (Passifloraceae, Malpighiales), and paleobotanical implications
Authors: Lagrange Flavien , Martínez Camila , Del Rio Cédric
Published: June 2024

The fossil record of the diverse subfamily Passifloroideae (>750 species and 17 genera) is relatively poor. Despite the distinctiveness of its leaves (glandular and often emarginate), most of the fossils from this group have been described from seeds. Fossil seeds have been recovered from Europe, and North and South America. A lack of information on seed morphology for all the genera and tribes of this subfamily has prevented a tribe-level identification of the fossils and a better understanding of their biogeographic patterns. The Passifloroideae is divided into three tribes: Passifloreae with 10 genera, Paropsieae with six genera and the monotypic Jongkindieae. This study provides new descriptions for 15 species from 5 genera from the mostly Afrotropical tribe Paropsieae based on herbarium material, and introduces an online seed database and a key for 100 species of Passifloroideae compiled from literature and direct observations. Our study shows a low morphological diversity among the seeds of Paropsieae in comparison to a much larger diversity within Passifloreae. Some rare morphologies are only present in Passifloreae and can be used to assign seeds to this tribe. Within the Paropsieae, Androsiphonia has seed that are very distinct from those in the other genera in the tribe and also from the rest of the subfamily. The genus Paropsia exhibits two main morphotypes, while the genera Barteria, Paropsiopsis and Smeathmannia have very similar seeds with a highly conserved morphology. These results suggest that living or fossil Paropsieae cannot be identified confidently based solely on seed characters.
Pengaruh Cedera Otak Kecil (Cerebellum) terhadap Perkembangan Bahasa Anak
Authors: Gulbi Hidayani Asi Saripa , Anggraini Nandeea Dwi , Sari Diyah Permata
Published: June 2024

The aim of this research is to understand the impact of cerebellar injury on children's language development. This study uses a library research approach. The findings indicate that injuries to the cerebellum have the potential to disrupt language development in children. The cerebellum, although small in size, plays a crucial role in coordinating movements and cognitive processes, including language. The effects of cerebellar injury include difficulties in articulation, disruptions in speech fluency, challenges in language comprehension and expression, and impairments in non-verbal communication. These issues arise due to disruptions in the fine motor coordination of the muscles needed for proper speech and language expression. The importance of appropriate intervention and treatment, such as physical therapy, speech therapy, and special educational approaches, is highlighted to help children overcome these difficulties and support their language development. In conclusion, a deeper understanding of the relationship between cerebellar injury and children's language development can aid in providing more effective interventions to improve outcomes for children affected by cerebellar injuries.
К гармонизации «Евразийского законодательства» сквозь призму технического регулирования и стандартизации (на примере России и Армении) / On the Way to Harmonization of «Eaurasian Legislation» Through Technical Regulation and Standardization (Russia and Armenia Overview)
Authors: Donchenko Anna V.
Published: June 2024

The article analyzes the issues of the Eurasian integration in the context of the applicable technical regulation standards, including standardization, accreditation, conformity assessment, state control (supervision) over compliance with the EAEU technical regulations. One of the main article’s endpoints is that the development of uniform standards for the Union member states will lead to a reduction in import of goods and positively effect on the import substitution programs.
Օսմանյան բանկի գրավումն ու Խանասորի արշավանքը «Դրօշակ» պարբերականի էջերում / The Capture of the Ottoman Bank and the Campagn of Khanasor on the Magazine “Droshak”
Authors: Hovsepyan Karine G.
Published: June 2024

In the history of the people’s liberation struggle of Western Armenia, significant place is taken by such offensive actions as the capture of the Ottoman bank and the campagn of Khanasor. Many authors referred to thess issues, but in the article the struggle is presented according to the data of the magazine “Droshak”, which reflected the events of those years with the greatest accuracy, since its information was supplemented by letters from direct participants and luminaries of that struggle, written under fresh impressions in the turmoil of events. This circumstance is of great importance, fruition since the memoirs of the liberation figure were written years events and many detailed were missing. “Droshak” is designed to fill this gap. The organizer of these offensives, the Dashnaktsutyun party, hoped with these actions to attract the attention of Evropean states to the Armenian reforms, which never came to realizing.
Հայաստանի տնտեսական արդյունավետության պարամետրային և ոչ պարամետրային գնահատումը / Parametric and non-parametric evaluation of economic efficiency of Armenia
Authors: Mkrtchyan Tatul M. , Navasardyan Michael A.
Published: June 2024

In modern economics, two main approaches are used to measure production efficiency: frontier and non-frontier. Each of them can be calculated in parametric and non-parametric ways. The non-frontier approach is based on the theory that the country is technically efficient, in other words, the actual output itself is the maximum possible output. Whereas, according to the frontier approach, efficiency is defined as the actual output's score relative to the production frontier, which is considered a tangible advantage over the non-frontier approach. Based on the data of 2000-2021, for 47 middle-income countries, including Armenia, we calculated the GDP production efficiency of each country in parametric and non-parametric ways using the stochastic frontier model and the Malmquist index, respectively. Armenia has a lower efficiency score than the average for the countries studied for the period under review, however, in terms of efficiency growth, the country's rating is relatively high. In the first ten years of the observed period, the increase in the RA standard of living was not caused by an increase in efficiency, unlike the next decade. The efficiency of RA GDP production is mainly determined by technical efficiency. The country needs to expand production frontier and improve scale efficiency.
Budget Program Evaluation in Armenia as a Tool to Improve the Effectiveness of Public Spending
Authors: Chapanyan Taguhi S.
Published: June 2024

In the last decade, like in many countries of the world, as well as in Armenia, significant budget reforms have taken place. An important part of those reforms is the introduction of the budget program evaluation system. The paper discusses the problems of the Armenian budget system and importance of introduction of evaluation system, as well as reviews alternative models of the introduction of this system. Thus, the purpose of the article is to develop theoretical, methodological, as well as practical recommendations regarding the implementation of the budget program evaluation system in RA as a tool to improve the efficiency of public spending. By examining successful experience, the article seeks to offer actionable insights for policymakers, government officials, and stakeholders, thus the article highlight the importance of stable and transparent budget program evaluation system in ensuring accountability, resource optimization, and the delivery of tangible benefits to the Armenian population. The article also addresses challenges in the introduction of an evaluation system, such as data limitations, institutional capacity, and stakeholder engagement.
The role of Acharya Madhva’s pilgrimages for the Mādhvas of Udupi
Authors: Gharibyan Vahe K.
Published: June 2024

In Hinduism, pilgrimage (Sanskrit: तीर्थयात्रा, tīrtha-yātrā) is a fundamental element in the lives of devotees. Pilgrimage as an integral part of religious life is used by the followers of Hinduism as a process which promotes spiritual progress. There are many places of pilgrimage in India, as it has very rich spiritual traditions. For Mādhvas of Udupi, tīrtha-yātrās is also an undivisible part of their spiritual life.
There are a few academic works (e. g. B. N. K. Sharma “The Philosophy of Madhvacharya” and “History of the Dvaita School of Vedanta and its Literature”, Vasudeva Rao “Living traditions in Contemporary Context: The Madhva Matha of Udupi”) about the ethnographic peculiarities of the Mādhva Vaiṣṇava Sampradaya , such as the description of pilgrimage practice in Madhva tradition. Acharya Madhva’s pilgrimages to Badrinath and other holy places were discussed historically by scholars, but there isn’t study on its influence and role in religious culture for the Mādhvas of Udupi.
For this article the study of Narayana Panditacharya’s hagiographic work called "Madhva Vijaya" which is about the life of Madhvācārya gives an opportunity to comprehend the peculiarities of the pilgrimage practice of Madhva and it’s cultural aspects for Mādhvas of Udupi.
Социальные взгляды Гермеса Трисмегиста / Social Views of Hermes Trismegistus
Authors: Grigorian Ernest R.
Published: June 2024

t. The article analyzes the social views of the famous ancient sage - Hermes Trismegistus. His concept of improving a person’s moral character is analyzed in detail, his views on the need to educate society are highlighted, and these views are compared with modern sociological concepts. The deeper approach of Hermes Trismegistus is emphasized, imbued with universalism, synthesizing natural and social laws. At the end, information about its origin and period of existence is provided
Iatrogenic Crimes During a Pandemic
Authors: Bayanduryan Hovhannes H. , Hakobyan Anush V
Published: June 2024

In the context of the COVID-19 pandemic, the issue of criminal law consolidation of the concept of “medical error” in criminal law has become especially acute. The new coronavirus infection COVID-19 pandemic has become a serious challenge for the national healthcare system. Foreign theory increasingly adheres to the idea of mitigating the criminal liability of medical workers for medical errors. It is concluded that the general basis for bringing a doctor to criminal liability in foreign countries is a gross violation of generally accepted standards of medical care. At the same time, the COVID-19 pandemic plays an important role in rethinking the domestic approach to understanding responsibility for iatrogenics and the need for its differentiation.
The role of International Organizations in the issue of personal data protection
Authors: Abramova Anna G.
Published: June 2024

The article explores the role of international organizations in protecting personal data in the context of the modern digital world. Key aspects of international cooperation in this area are considered, including the establishment of common norms and standards for data protection, coordination of efforts to combat global cybersecurity threats, and creation of mechanisms to respond to cross-border data leaks. The challenges associated with harmonizing different legal frameworks and cultural differences are discussed, as well as the role of international organizations in promoting dialogue and mutual understanding between countries and cultures. The article also highlights the principle of independence of international organizations and their importance in ensuring fair and effective solutions to global data protection issues. This general overview emphasizes the importance of cooperation and coordinated actions at the international level to ensure the security and confidentiality of personal data on a global scale.
Real and Formal Legal Possibilities in Constitutional Norms
Authors: Leyloyan Hasmik A.
Published: June 2024

The philosophical-legal category "legal possibility" concerning legal norms can be considered from the perspective of the possibility of creating legal norms or lawmaking, from the perspective of the legal possibility of realization of legal norms, as well as from the perspective of the legal norms themselves or their content. Taking these aspects into account, the author especially emphasizes the importance of theoretical analysis of legal possibilities in constitutional norms of law, since it is difficult to overestimate the role of the Constitution, as the fundamental law, in the legislative system, as well as in the life of the state and society.
Examining the concept or category of "legal possibility" in the constitutional norms of law, the author, using examples of articles, provisions, or principles laid down in the Constitution of the Republic of Armenia, identifies real and formal legal possibilities and conducts an analysis of objective and subjective factors (the interrelation of legal and social reality, the law-making activities of legislative bodies, the behavior of subjects of law, etc.) for transforming the formal possibilities of constitutional norms into real legal possibilities.
According to the conclusion presented in the article, the analysis of real and formal legal possibilities in constitutional norms has important methodological significance, as it examines and identifies the legal prerequisites. This enables a deep understanding of the structure of the effective realization of constitutional norms, which is one of the pressing issues in lawmaking activities, also holds significant importance in law implementation practice.
Post-covid developments in capital flows: what has changed?
Authors: Kalantaryan Hayk L.
Published: June 2024

As the global economic environment changes so does the patterns of international capital flows. Since the beginning of globalization and particularly throughout the Great Moderation, capital flows have been recognized as an indispensable cornerstone for financial liberalization, deeper integration and economic growth
The Modern Technologies of Time Management in Small Organizations
Authors: Sahakyan Ani S.
Published: June 2024

The purpose of the article is to reveal the necessity and effectiveness of modern time management technologies in small organizations.
The tasks of the article are to study the features of traditional and modern technological methods of time management and their application in organizations, as well as to identify the problems of time management using the example of the Paratus educational center.
Empirical research methods were used in the study.
As a result of the study, it can be concluded that each organization has its own unique internal culture and its own special attitude towards such an intangible resource as time. Time management allows you to effectively organize working time to achieve optimal results. In the fast pace of competition and changes in the field of information technology, effective time management plays a crucial role in achieving success. In this sense, time management can be considered not only as a way to optimize the processes of setting and solving problems, but also contributes to the maintenance and development of the stability of the organization.
As a result of the study, taking into account the specifics of the given organization, ways of increasing the efficiency of time management were developed.
The problems of human resource development and the main ways to solve them
Authors: Tovmasyan Lusine G. , Davtyan Vera G
Published: June 2024

The effectiveness of any organization depends on a number of factors, including a well-designed human resource management system. A properly formulated human resource management strategy is a guarantee of success for a modern organization. In turn, the systemic effectiveness of human resource management depends on its properly formulated and implemented processes, timely and accurate identification of problems in each process, as well as the development of correct, effective, targeted solutions and recommendations for their resolution.
The Partial Solution of First Price Sealed Bid Auction in the Scope of Mechanism Design Theory and With Uniformly Distributed Types
Authors: Petrosyan Rafayel M.
Published: June 2024

In the article the first price sealed bid auction has been analysed within the scope of mechanism design theory and with uniformly distributed types. The sealed bid auction consisting of two of agents has been observed finding the partial solution to the auction. Bayesian Nash equilibrium strategies, the equilibrium state, and the implemented social choice function for the auction have been evaluated. The mechanism has been designed to truthfully implement the social choice function for the auction consisting of two agents. The variables such as the probability of an agent to win, the expected utility of an agent and the expected revenue of the seller have been evaluated.
The Role of Armenian Forces in the Defense of Tabriz (September 1724)
Authors: Ayvazyan Armen M.
Published: June 2024

This study delves into the hitherto unexplored involvement of Armenian troops in the defense of Tabriz in 1724, drawing on an extensive analysis of historical materials. In 1723-1724, the Ottoman Empire launched invasions into Safavid Iran from several directions. By September 1724, one Ottoman army, led by Abdullah Pasha of Van, advanced towards Tabriz and attempted to storm the city. During the ensuing battle, the Turkish forces were soundly defeated and driven back, suffering approximately 20,000 casualties. European sources emphasize the significant role played by Armenian military units in the decisive victory at the Battle of Tabriz, the sole triumph for Persian forces during the 1724 campaign. Notably, the majority of these units arrived from Karabakh. The Armenian troops were instrumental in virtually annihilating the elite Janissary corps within Abdullah Pasha's army. This article identifies the Armenian detachments involved in the defense of Tabriz, listing their commanders: Parsadan-bek, Melik-Egan, Pilibek Basaurov, David, Abidjan, Aghajan, Akhnazar, Balig, among others.
Памятники армянской архитектуры и топонимики Великобритании / The Monuments of Armenian Architectures and Toponymy in the Great Britain
Authors: Poghosyan-Khaghbakyan Gagik H.
Published: June 2024

The article presents the head of a multi-volume atlas of the catalog «The monuments of Armenian architecture and place names abroad». The article briefly presents the existing monuments. The main part of the article is a table-list of Armenian monuments of architecture and toponymy in the Great Britain, after which a list of literature is given
Памятники армянской архитектуры и топонимики Ирландии / The Monuments of Armenian Architectures and Toponymy in the Ireland
Authors: Poghosyan-Khaghbakyan Gagik H.
Published: June 2024

The article presents the head of a multi-volume atlas of the catalog «The monuments of Armenian architecture and place names abroad». The article briefly presents the existing monuments. The main part of the article is a table-list of Armenian monuments of architecture and toponymy in the Ireland, after which a list of literature is given.
Trends in changes in poverty levels in the Republic of Armenia
Authors: Baghdasaryan Gevorg B.
Published: June 2024

Today, the whole world is faced with ever-increasing demonstrations of social inequality, one of which is poverty. Especially in 2019-2020 Social inequality around the world has worsened as the pandemic has hit the poor hardest. According to the World Bank, more than 700 million people in the world today live in extreme poverty, spending just $2.15 a day, which is the extreme poverty threshold. After decades of efforts to reduce global poverty, shocks and crises in the global economy in recent years have led to a worsening of the situation. As a result, the problem of poverty has worsened in low-income countries, which are still unable to recover and return to their previous pace. At the current pace, the goal of ending global poverty will not be achieved by 2030, according to the World Bank.