bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationships between the average semester growth rates of lexical sophistication in L2 English writing at secondary school: A learner corpus analysis
Authors: ROKOSZEWSKA KATARZYNA
Published: December 2021

In line with Complex Dynamic Systems Theory (CDST), the aim of the paper is to examine dynamics and causality among the growth rates of lexical sophistication in L2 writing development. The study was based on The Written English Developmental Corpus of Polish Learners (WEDCPL) which consists of over 1,900 essays composed during 21 repeated measurements by 100 learners over three years (2014–2017) at secondary school. Lexical sophistication, operationalised as different frequency levels, was analysed with the Lextutor software (Cobb 2014). The results indicated that the learners relied on the first frequency level. The monthly growth rates (MGRs) of the frequency levels were variable but no significant peaks were registered. The relationships between the average semester growth rates (ASGRs) revealed competition between the first and higher frequency levels, and some support between the higher levels. Thus, developing learners’ lexis beyond the first level counteracts the production of lexically unsophisticated texts and supports the use of more advanced words.
Postcatastrophic Re-Reading of Tadeusz Hołuj’s Puste pole
Authors: Adamczak Katarzyna
Published: December 2021

This article deals with the re-interpretation of Tadeusz Hołuj’s drama Puste pole (1963; The Empty Field) and its theatrical staging by Józef Szajna in 1965. Based on the drama I want to demonstrate how the artists – who were both survivors of the concentration camp in Auschwitz – managed re-presenting the Holocaust despite the political situation and the accompanying anti-Semitic government campaign in Poland in the 1960s. The reception of the drama of then and nowadays shows how that re-presentation was once interpreted due to the political circumstances, which made the issue of the Holocaust and the Jews bannend from public life, language, and memory. Finally I explore how Hołuj’s drama can be read today when we approach it via postcatastophic re-reading determined by after-knowledge, retrospection, and retroactivity.
Forgotten Prosaic Works (Forming a Literary Image of the Holocaust in Slovak Literature of the 1940s and 1950s)
Authors: Hučková Dana
Published: December 2021

The iconography of the Holocaust in Slovak literature between the late 1940s and mid-1950s was also created by texts that are almost forgotten today. The article discusses prosaic works by two Slovak writers. Some of these works belong to the early period of the Holocaust reception and some of them originated later. Literary history paid little or no attention especially to older works. One of the writers discussed in the article, Hela Volanská, disappeared from the literary life after 1970. The article discusses her works O živých a mŕtvych (On Those Who Are Alive and Dead, 1948) and Ako na cudzej svadbe (As at Somebody Else’s Wedding, 1987/2009). The other writer discussed in this article, Ľudo Zúbek, is an established name of Slovak literature, but is known mostly as an author of historical and biographical fiction, including a novel Jar Adely Ostrolúckej (Adela Ostrolúcka’s Spring, 1957), which is today incorrectly considered literature for young female readers. Other Zúbek’s works reached very little attention and acknowledgement. The article discusses his prosaic works Rozbitá dúha (Broken Rainbow, 1956) and Vltava (without date).
The Walpurgis Night): A New Variation on the Theme of the Holocaust. Several Suggestions as for the Future Reception of the Film
Authors: Skibska Anna Maria
Published: December 2021

In the essay, I make an attempt to present several ways, in which the Western canon of literature, music, and cinema has influenced Noc Walpurgi. With regard to this, Marcin Bortkiewicz’s film turns out to be a work made of many citations, in Walter Benjamin’s terms, drawn extensively on Goethe’s Faust, Mann’s The Magic Mountain, Bulgakov’s The Master and Margarita, Wagner’s Ride of the Valkyries, and Puccini’s Turandot, and the film noir poetics elaborated in the 40s and 50s of the twentieth century. Based on Magdalena Gauer’s monodrama Diva, Noc Walpurgi illuminates in the highly expressionist manner an alienated, cynical, and despotic psyche of Nora Sadler, a great opera singer, who is tormented by the Holocaust past.
Od badań nad wątkami żydowskimi do nowego literaturoznawstwa
Authors: Firlej Agata
Published: December 2021

Lektury. Recepcja literackich i artystycznych dzieł o Szoa
Poetycko-muzyczne korespondencje w twórczości Josipa Severa
Authors: Darasz Zdzisław
Published: December 2021

Lektury. Poza tematem
From Report to Mythus. Jiří Kolář’s Plays as Creative Transformation of the Shoah Testimonies
Authors: Firlej Agata
Published: December 2021

Kolář’s plays Chléb náš vezdejší and Mor v Athénách, written at the turn of the fifties and the sixties, are the examples of aestheticization of testimonies and other texts about the Shoah. Kolář’s creative path is in a way pars pro toto of artistic and literary search of many authors reacting to the experience of Shoah and to many texts describing this hecatomb. Doubt in the previous aesthetics and in the polyphonic load of words is one of the most common experiences in the second half of the 20th century – until now. The author activates memory or cultural connotations of receiver and by eliminating a factual layer that could became a psychological safety valve that distracts, focuses a viewer (reader) on the most important and by it the most difficult to bear: to the event itself.
“Abandoned Secrets”. The Question of the Holocaust Narratives in Ukrainian Literature
Authors: Golebiowski Anja
Published: December 2021

The reportage Ukraine without Jews (1943) by the Soviet writer Vasilij Grossman is one of the earliest public reports on the Holocaust. Although Ukraine had been in the centre of the Nazi mass murder and single voices like the ones of Grossman or Il’ja Ėrenburg even called betimes attention to the ongoing genocide of Ukrainian Jews, any tradition of Ukrainian Holocaust narratives has not been developed yet. Since its independency in 1991, there are attempts to participate in the Western memory discourse, but by now, they have rather no broader impact. The reception of the debate on the Holocaust serves more likely as a backdrop for its own discourse of victimization, the Holodomor, which is used for developing a national identification within the current Ukrainian nation-building process. Since the Orange Revolution, as the Ukraine has found itself in a critical phase of a socio-political upheaval, some texts of leading Ukrainian writers (Marija Matios, Oksana Zabužko, Jurij Vynnyčuk) have occurred that carefully raise the subject of the Holocaust, or rather the gap in the Ukrainian consciousness. This paper gives an overview about the texts and works out the narrative strategies, whereby only the coming years will show, if these texts constitute the beginning of a Ukrainian Holocaust literature.
The Shoah in Poland in the Work of Jiří Weil: Translations and Literary Reference*
Authors: Hříbková Hana
Published: December 2021

Jiří Weil (1900–1959) is currently associated in particular with novel-writing. His works Moskva- -hranice (Moscow to the Border), Život s hvězdou (Life with a Star) and Na střeše je Mendelssohn (Mendelssohn is on the Roof) has been translated into several world languages. Jiří Weil was also a journalist, a researcher at the Jewish Museum in Prague and a translator. This study The Shoah in Poland in the work of Jiří Weil focuses on his translations of Polish poets and his literary work dealing with the Shoah and set in postwar Poland, Warsaw, Łódź and Auschwitz.
When Rural and Urban Become “Us” versus “Them”: How a Growing Divide is Reshaping American Politics
Authors: Brown Trevor , Mettler Suzanne , Puzzi Samantha
Published: December 2021

The United States’ long-standing broad “catch-all” political parties have historically combined voters from distinct regions of the country, each including both rural and urban dwellers. Since the late 1990s, however, rural Americans nationwide have increasingly supported the Republican Party, while urbanites have persisted in their allegiance to the Democratic Party. The growing rural-urban divide has become mapped onto American polarization in ways that are fostering tribalism. This place-based cleavage is now contributing to the transformation of the nation’s politics and that of many states. It also threatens to have deleterious effects on democracy.
Improved gas sand facies classification and enhanced reservoir description based on calibrated rock physics modelling: A case study
Authors: Shakir Urooj , Ali Aamir , Amjad Muhammad Raiees , Hussain Muyyassar
Published: December 2021

Rock physics provides a dynamic tool for quantitative analysis by developing the basic relationship between fluid, lithological, and depositional environment of the reservoir. The elastic attributes such as impedance, density, velocity, V
p/V
s ratio, Mu-rho, and Lambda-rho are crucial parameters to characterize reservoir and non-reservoir facies. Rock physics modelling assists like a bridge to link the elastic properties to petrophysical properties such as porosity, facies distribution, fluid saturation, and clay/shale volume. A robust petro-elastic relationship obtained from rock physics models leads to more precise discrimination of pay and non-pay facies in the sand intervals of the study area. The Paleocene aged Lower Ranikot Formation and Pab sandstone of Cretaceous age are proven reservoirs of the Mehar gas field, Lower Indus Basin. These sands are widely distributed in the southwestern part of the basin and are enormously heterogeneous, which makes it difficult to distinguish facies and fluid content in the reservoir intervals. So, an attempt is made in this paper to separate the reservoir facies from non-reservoir facies by using an integrated approach of the petro-elastic domain in the targeted sand intervals. Furthermore, missing logs (S-sonic and P-sonic) were also synthesized in the wells and missing intervals along with improving the poor quality of the density log by captivating the washouts and other side effects. The calibrated rock physics model shows good consistency between measured and modelled logs. Petro-elastic models were predicted initially using petrophysical properties and incorporated at true reservoir conditions/parameters. Lithofacies were defined based on petrophysical cut-offs. Rock physics modelled elastic properties (Lambda-rho versus Mu-rho, impedance versus V
p/V
s ratio) were then cross-plotted by keeping lithofacies in the Z-axis. The cross-plots clearly separated and demarcated the litho-fluid classes (wet sand, gas sand, shale, and limestone) with specific orientation/patterns which were randomized in conventional petrophysical analysis.
Quercetin increases mitochondrial proteins (VDAC and SDH) and downmodulates AXL and PIM-1 tyrosine kinase receptors in NRAS melanoma cells
Authors: Rocha-Brito Karin J. P. , Clerici Stefano Piatto , Cordeiro Helon Guimarães , Scotá Ferreira Amanda Petrina , Barreto Fonseca Emanuella Maria , Gonçalves Paola R. , Abrantes Júlia Laura F. , Milani Renato , Massaro Renato Ramos , Maria-Engler Silvya Stuchi , Ferreira-Halder Carmen V.
Published: December 2021

Melanoma is a type of skin cancer with low survival rates after it has metastasized. In order to find molecular differences that could represent targets of quercetin in anti-melanoma activity, we have chosen SKMEL-103 and SKMEL-28 melanoma cells and human melanocytes as models. Firstly, we observed that quercetin was able in reducing SKMEL-103 cell viability, but not in SKMEL-28. Besides that, quercetin treatment caused inhibition of AXL in both cell lines, but upregulation of PIM-1 in SKMEL-28 and downregulation in SKMEL-103. Moreover, HIF-1 alpha expression decreased in both cell lines. Interestingly, quercetin was more effective against SKMEL-103 than kinases inhibitors, such as Imatinib, Temsirolimus, U0126, and Erlotinib. Interestingly, we observed that while the levels of succinate dehydrogenase and voltage-dependent anion channel increased in SKMEL-103, both proteins were downregulated in SKMEL-28 after quercetin’s treatment. Furthermore, AKT, AXL, PIM-1, ABL kinases were much more active and chaperones HSP90, HSP70 and GAPDH were highly expressed in SKMEL-103 cells in comparison with melanocytes. Our findings indicate, for the first time, that the efficacy of quercetin to kill melanoma cells depends on its ability in inhibiting tyrosine kinase and upregulating mitochondrial proteins, at least when SKMEL-103 and SKMEL-28 cells response were compared.
Wirtschaft und Recht: Probleme struktureller Kopplung
Authors: Luhmann Niklas
Published: December 2021

Ausgehend von der Theorie operational geschlossener Systeme und dem damit zusammenhängenden Informationsbegriff kann das Verhältnis solcher Systeme zu ihrer Umwelt über den Begriff der strukturellen Kopplung erläutert werden. Wenn man diese Konzepte auf das Verhältnis von Wirtschaft und Recht anwendet, können klassische Fragestellungen neu analysiert werden: So können Eigentum und Vertrag als evolutionär entstandene gesellschaftliche Einrichtungen der Kopplung beider Systeme verstanden werden, die einerseits Systemzustände und andererseits Systemereignisse koordinieren – und dies mit ganz unterschiedlichen Folgen für beide Systeme. Entsprechend gestaltet sich auch die Entwicklungsgeschichte der entsprechenden Semantiken im Zuge der funktionalen Ausdifferenzierung der Gesellschaft. Die gesellschaftsevolutionär erfolgreiche Etablierung der Kopplungsformen bedeutet aber noch keine Zukunftsgarantie. Insbesondere vor dem Hintergrund der sich ändernden Temporalstrukturen der modernen Gesellschaft in der Form von Technikfolgen, der Ökologiefrage und der Sensibilisierung für Risiken wird vielmehr das geräuschlose Funktionieren der strukturellen Kopplungen, wie es z. B. die liberale Theorie von Eigentum und Vertragsfreiheit postulieren, zunehmend in Frage gestellt.
Komplexität, strukturelle Kontingenzen und Wertkonflikte
Authors: Luhmann Niklas
Published: December 2021

Temporalisierte, aus Operationen bestehende Systeme sehen sich vor das Problem des Dauerzerfalls gestellt, das sie nur dadurch lösen können, dass die Auswahl nächster Ereignisse hoch selektiv, aber nicht beliebig erfolgt. Sie benötigen dafür ein Gedächtnis. Für den Fall der aus Kommunikation bestehenden Gesellschaft übernimmt die Semantik als bewahrenswerter Sinn diese Funktion. Die hier vorgestellte These lautet, dass die moderne Orientierung an „Werten“ mit der funktionalen Differenzierung der modernen Gesellschaft zusammenhängt, während ältere, vorwiegend hierarchisch stratifizierte Gesellschaften in ganz anderer Weise auf die Selektionszwänge ihrer eigenen Komplexität reagiert hatten. Die mit der funktionalen Differenzierung einhergehende zunehmende Kontingenz macht die Einführung neuer „inviolate levels“ nötig, diesem Bedarf trägt die Wertsemantik Rechnung. Kennzeichnend für die moderne Gesellschaft ist dann, dass Werte als implizites Wissen unterstellt werden und es keine Werthierarchie gibt. Abschließend wird die These der höheren strukturellen Komplexität der funktional differenzierten Gesellschaft auf einer zweiten, konkreteren Ebene noch einmal aufgenommen: der des Wechselspiels der generellen Inklusion der Gesamtbevölkerung in die Funktionssysteme und der nur selektiven Inklusion in Organisationen. Inwiefern unter diesen Bedingungen zunehmend kontingenter Identitäten die Semantik der nicht weiter begründungspflichtigen Werte noch ihre Funktion erfüllt, muss offen bleiben.
The Test Research on the Adsorption of Heavy Metal Ions by Ultra-Low Permeability Polymer-Bentonite with Chemical Resistance Stability
Authors: Cai Xiaoqing , Chen Ying , Liao Rao-ping , Wu Ze-xiang , Yu Chuang , Shi Tiantian , Wu Yinxia , Jiang Jifang
Published: December 2021

It is often difficult for the modification of impermeable bentonite to meet the requirements of low permeability, high chemical resistance, and strong adsorption performance. Based on the low permeability and high chemical resistance of the modified bentonite with sodium polyacrylate (SPB), the adsorption characteristics of the modified bentonite on copper were further compared and analyzed. A series of batch adsorption experiments were performed considering the effects of contact time, pH, temperature, and adsorbate concentration. The morphological changes and microstructure of raw bentonite and SPB at different cupric ion (Cu2+) concentrations were studied through scanning electron microscopy. The pore structure was analyzed with mercury intrusion porosimetry. Kinetic, Langmuir, and Freundlich models were applied to analyze the adsorption mechanism. The results indicated that the SPB not only improves the impermeability and chemical resistance of bentonite but also significantly improves the adsorption of heavy metals. The saturated adsorption capacity of Cu2+ is increased by 116.08 %. The modification mechanism of SPB is that the mineral particles of bentonite were coated by a negatively charged and hydrophilic group (carboxyl group, -COO-). The protective effect of the polymer on the bentonite is the main reason for its chemical resistance, and the solid bonding of the polymer closes the pores of the material, thus reducing the hydraulic performance. Based on the above, it can be concluded that SPB has the characteristics of lower permeability, stronger chemical corrosion resistance, and greater heavy metal adsorption capacity, which makes it an ideal anti-seepage material for landfill.
FAKTOR-FAKTOR YANG MEMPENGARUHI KURANG BERMINATNYA MAHASISWA PGSD UPP TEGAL PADA PENDIDIKAN SENI RUPA DALAM PENYELESAIAN TUGAS AKHIR SKRIPSI
Authors: Fathurrahman Moh.
Published: December 2021

Tujuan yang ingin dicapai dalam penelitian ini adalah upaya untuk mengetahui faktor-faktor yang berkontribusi terhadap kurang berminatnya mahasiswa dalam mengkaji mata kuliah Pendidikan Seni sebagai jalur dalam penyelesaian Tugas Akhir. Subjek pada penelitian ini adalah mahasiswa PGSD UPP Tegal tingkat akhir. Metode penelitian yang diterapkan adalah metode case study dan metode survey dengan teknik pengolahan data analisis deskriptif. Hasil penelitian menunjukkan bahwa kurang minatnya penyelesaian tugas akhir karena kurang ketersediaannya buku referensi, mahasiswa merasa kurang memiliki bakat di bidang seni rupa, kurangnya contoh skripsi yang berhubungan dengan latar belakang dan kompetensi.Kata Kunci: faktor; minat; seni rupa; skripsi
Conservation Education for Elementary School Students
Authors: Soenarno Sri Murni , Miranti Astari
Published: December 2021

The success of a sustainable development program requires support from nature conservation efforts. It happens because one of the assets for development is natural resources. Pro-conservation people are needed to ensure the sustainability of the nature conservation program is a success. Therefore, conservation education is urgent to be learned in school. The purpose of this study was to observe the responses of elementary school students and teachers in studying nature conservation concepts. The research methods were using the experimental treatment in elementary schools in Jakarta and qualitative analysis. The results showed that both of the students and teachers gave positive responses to learn nature conservation conveyed through various games because the learning situation was amusing and unique. The use of a combination of learning methods is following constructivist learning theory.
Exercise increases NPY/AgRP and TH neuron activity in the hypothalamus of female mice
Authors: Landry Taylor , Shookster Daniel , Chaves Alec , Free Katrina , Nguyen Tony , Huang Hu
Published: December 2021

Recent evidence identifies a potent role for aerobic exercise to modulate the activity of hypothalamic neurons related to appetite; however, these studies have been primarily performed in male rodents. Since females have markedly different neuronal mechanisms regulating food intake, the current study aimed to determine the effects of acute treadmill exercise on hypothalamic neuron populations involved in regulating appetite in female mice. Mature, untrained female mice were exposed to acute sedentary, low- (10 m/min), moderate- (14 m/min), and high (18 m/min)-intensity treadmill exercise in a randomized crossover design. Mice were fasted 10 h before exercise, and food intake was monitored for 48 h after bouts. Immunohistochemical detection of cFOS was performed 3 h post-exercise to determine the changes in hypothalamic neuropeptide Y (NPY)/agouti-related peptide (AgRP), pro-opiomelanocortin (POMC), tyrosine hydroxylase (TH), and SIM1-expressing neuron activity concurrent with the changes in food intake. Additionally, stains for pSTAT3tyr705 and pERKthr202/tyr204 were performed to detect exercise-mediated changes in intracellular signaling. Briefly, moderate- and high-intensity exercises increased 24-h food intake by 5.9 and 19%, respectively, while low-intensity exercise had no effects. Furthermore, increases in NPY/AgRPARC, SIM1PVN, and TH neuron activity were observed 3 h after high-intensity exercise, with no effects on POMCARC neurons. While no effects of exercise on pERKthr202/tyr204 were observed, pSTAT3tyr705 was elevated specifically in NPY/AgRP neurons 3 h post-exercise. Overall, aerobic exercise increased the activity of several appetite-stimulating neuron populations in the hypothalamus of female mice, which may provide insight into previously reported sexual dimorphisms in post-exercise feeding.
Descripción del nido de Phyllotis andium (Cricetidae: Phyllotini), en un matorral seco interandino en Ecuador
Authors: Nivelo-Villavicencio Carlos , Quezada Amanda B. , Vieira José
Published: December 2021

En este trabajo describimos la estructura del nido de Phyllotis andium Thomas, 1912 en un matorral seco interandino al sur de la provincia del Azuay en Ecuador y el uso de un pasto introducido en su fabricación. Se presentan también observaciones sobre sociabilidad y abundancia de esta especie. Estos datos proporcionan nueva información sobre las relaciones intraespecíficas de estos roedores y su historia natural.
A new species of Podanotum Torres & Johnson, 1996 (Lepidoptera, Lycaenidae) from northern Peru
Authors: Farfan Jackie , Cerdeña Gutierrez Jose Alfredo , Lazo-Rivera Ana , Huanca-Mamani Wilson , Bálint Zsolt
Published: December 2021

We describe a new species of the genus Podanotum Torres & Johnson, 1996, Podanotum pajaten Farfán, Cerdeña & Bálint sp. nov. from northern Peru, associated with the Andean treeline ecotone adjacent to cloud forest and wet grassland at 3200 m above sea level. Description of this new species is based on one female adult and is distinguishable from its congeners by the combination of the following morphological characters: dorsal wing pale blue, forewing discoidal line present on ventral side, hindwing tailed, and ostium bursae distally toothed. Podanotum pajaten sp. nov. is separated geographically from the closest spatial species, P. glorissimum Bálint & Wojtusiak, 2002, by approximately 100 km to the south, and represents the second species described for Peru. An identification key to all known species of Podanotum is provided, stating their distributions by country.
Publicación registrada en Zoobank/ZooBank article registered:LSIDurn:lsid:zoobank.org:pub:FE6C35CF-2609-410C-9CB5-57737D02DFC3Acto nomenclatural/nomenclatural act:Podanotum pajaten Farfán, Cerdeña & Bálint, 2021LSIDurn:lsid:zoobank.org:act:B8CE9125-0182-4DAB-BD92-D15DC4E16C47
Shockwave and Non-transfemoral Transcatheter Aortic Valve Replacement
Authors: Payabyab Eden C , Elbaum Lindsay S , Sharma Navneet , George Isaac , Mick Stephanie L
Published: December 2021

Transcatheter aortic valve replacement (TAVR) has become a widely adopted treatment modality for severe aortic stenosis. Transfemoral access is the approach of choice; however, approximately 25% of patients undergoing TAVR also have concomitant peripheral arterial disease. The recent advent of intravascular lithotripsy has enabled preservation of transfemoral access in some patients; although, a proportion still require alternative, non-femoral access. Alternative access sites can be broadly categorized into transthoracic and peripheral, facilitated by surgical or percutaneous techniques. In this review, the technical details and clinical outcomes of various TAVR accesses are discussed. Initially, transthoracic approaches were most common, but recently, the trend has been toward alternative peripheral access due to superior outcomes. Although there are no randomized data to support all the alternative access sites, the experiences reported provide available options for a large portion of patients to be candidates for TAVR. The intervention site should be selected by a multidisciplinary heart team based on patient anatomical factors and institutional expertise.
Metodologias ativas e tecnologias digitais no ensino de Ciências
Authors: Scheunemann Camila Maria Bandeira , De Almeida Caroline Medeiros Martins , Lopes Paulo Tadeu Campos
Published: December 2021

As metodologias ativas e as tecnologias digitais vêm ganhando espaço nos contextos de ensino contemporâneos, tornando-se necessária a inclusão desta temática na formação de professores, tanto inicial, quanto continuada, a fim de prepará-los reflexiva e criticamente para o seu uso. Esta pesquisa teve por objetivo verificar e analisar as concepções e opiniões de licenciandos e professores atuantes sobre as metodologias ativas e tecnologias digitais no ensino de ciências. Trata-se de uma pesquisa qualitativa, de cunho exploratório. Foi realizado um minicurso para licenciandos e professores em atuação sobre metodologias ativas e tecnologias digitais no ensino de ciências. Os dados foram coletados por meio de questionários de pré e pós-teste e analisados pela análise de conteúdo. Observou-se, inicialmente, que os participantes confundiam metodologias ativas com recursos tecnológicos, visão que se modificou parcialmente após o minicurso. Entre as metodologias mais citadas, destacaram-se as experiências (aulas práticas) no pré-teste, e a sala de aula invertida, jogos e método do caso no pós-teste. Os professores dizem acreditar no potencial das metodologias ativas e das tecnologias digitais como auxílio para o ensino e a aprendizagem de ciências.
Palavras-chave: Metodologias ativas; tecnologias digitais; ensino de Ciências; formação de professores.
The antimalaria drug artemisinin displays strong cytotoxic effect on leukaemia lymphocytes in combination with vitamin C and pro-vitamin K3
Authors: Ivanova D. , Yaneva Z. , R. Bakalova R. Bakalova , Semkova S. , Zhelev Zh.
Published: December 2021

This study investigated the anticancer effect of the anti-parasitic drug artemisinin in combination with two redox modulators: vitamin C and pro-vitamin K3 (C/K3) The experiments were conducted on leukaemia cells Jurkat. Cells were treated with either artemisinin or C/K3 alone and with all three compounds. Cell proliferation and viability were analysed using trypan blue stating and automated cell counting. The results showed that artemisinin (>10 mM) suppressed cell proliferation activity, but did not induce cell death up to 500 mM. The drug demonstrated a clear cytostatic effect at concentrations 250- 500 mM – Jurkat cells did not proliferate, but were alive. The combination C/K3 (200:2, 300:3 mM/mM) applied alone did not affect cell proliferation and viability. Vitamins C/K3 in concentration ratio 500:5 (μM/mM) decreased cell proliferation activity by ~10%. The triple combination artemisinin/C/K3 manifested synergistic anti-proliferative effects at all concentration ratios analysed. This synergistic effect increased with increasing C/K3 concentration. Based on literature data, it was assumed that the anti-proliferative effect of the triple combination was mediated by changes in the redox-homeostasis of cancer cells. The C/K3 redox system likely acted on cancer mitochondria and increased superoxide production and activation of pro-apoptotic signals, specific for cancer cells. On the other hand, artemisinin could generate hydroxyl radicals as a result of activation of Fenton reactions, depleting intracellular reducing equivalents. Both redox mechanisms lead to activation of signal pathways for induction of cancer cell death.
Neutropenia in children: acquired neutropenia
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine, Volokha A.P.
Published: December 2021

Neutropenia is defined as a reduction in the absolute neutrophil count (ANC) below 1,500 cells/mcl in the blood. Neutropenia is a common laboratory finding in children. It is important to distinguish transient and benign causes from severe congenital neutropenia. Neutropenia can be classified in asymptomatic (mild), moderate, and severe form, the susceptibility to infection depending on ANC. Neutropenia can be either acquired or congenital. Infection, drugs, and immune disorders are the most common acquired causes while congenital causes are rare and confined mostly to infants and children. Transient neutropenia often accompanies viral infections in children, manifested in the period of acute viremia. Young children are characterized by autoimmune neutropenia (AIN), which has a benign course and a favorable prognosis. Autoimmune neutropenia is characterized by a decrease in the number of neutrophils as a result of the destruction of neutrophils in the peripheral blood by antineutrophil antibodies. The duration of AIN is usually 3–5 years. This is a self-limiting disease that in most cases does not require treatment. Despite the benign course, serious infectious complications can occur. Treatment of myeloid growth factors should be started after a previous bone marrow aspiration biopsy in children with severe infections or requiring surgical intervention. High doses of intravenous immunoglobulin and corticosteroids may be effective in treating AIN in patients with life-threating infections. The danger to the patient depends on the etiology, ANC and bone marrow status. The risk of infections is significantly increased in patients with ACN less than 500 cells/μ1. The most common loci of infections include the oral mucosa, skin, perirectal area, perineum. Oral ulcers and gingivitis are characteristic signs of clinically significant neutropenia, requiring the exclusion of its congenital causes. Severe infections in patients with neutropenia are caused by pyogenic or intestinal bacteria and Candida species. It is important to distinguish between transient or benign causes and severe congenital neutropenia or neutropenia associated with serious haematological or systemic disease. Clarification of the cause of neutropenia is important for determining management and prognosis. No conflict of interest was declared by the author. Key words: neutropenia, children, immunodeficiency, autoimmune neutropenia.
Fact-Checking as a Format for Self-Regulation of the Media Community
Authors:   Moscow Polytechnic University, Raspopova S. S.
Published: December 2021

The article examines the features of the functioning of mass communication, the number of participants in which has significantly expanded in recent years. New realities demanded a revision of the previously established norms of regulation of mass communication. The currently existing ethical documents, which basically represent the standards of professional behaviour of a journalist, cannot act as a full-fledged ethical regulator for all participants in mass communication due to the multidirectional nature of their activities. The agenda for media researchers today is the development of new approaches to the regulation of mass communication, one of which can be considered fact-checking.
Speech Features of the Interview Genre in Modern Tatar-Language Journalism
Authors:   Kazan Federal University, Sabirova L. R.
Published: December 2021

Changes in language are largely a process of loosening the old norm and gradually creating a new one. It is believed that the media contribute to the preservation of the norm and the maximum slowdown of changes. Newspapers and magazines fix the graphic appearance of the word, and radio and television — sound. Together they set grammatical, syntactic and other patterns, which guides the people who read and listen to them. The author of the article studied the speech features of the interview genre in modern Tatar journalism. Namely 3012 fragments were analysed and the following conclusions were made: due to the interview genre, phonetic, morphological, lexical, syntactic, orthoepic enrichment of the language occurs; many modern elements borrowed from the Internet are used in print magazines in the Tatar language; there is a tendency to reduce words, use abbreviations, typed language constructions, phraseological units, borrowings, terms, professionalisms, dialectisms, slang expressions, and it is also observed that in different printed publications in the Tatar language, different variants of using common terms are offered in interviews.
The Literary Jubilees in The USSR and Commemoration Practices in the Stalinian Culture”
Authors:   Ural Federal University, Nikolaev R. M. , Popov E. A. ,   Ural Federal University
Published: December 2021

The article is devoted to the specifics of the use of commemorative practices in the Soviet culture of the 1930–1950s. Using the example of the Pushkin jubilee of 1937 and the Gogol jubilee of 1952, a commemorative (appropriative) mechanism is shown that ensured the appropriation of a number of outstanding cultural figures of the previous period by Soviet culture. Thus, the iconic figures of Russian culture of the 19th century turned out to be an iconic part of the new Soviet culture, an element of its symbolic capital.
Innovations in Ornamental Culture as a Process of Loss of the Sacred (on the Example of Russian Textile Ornament of the XVIII — Early XX Centuries)
Authors:   Ivanovo State Polytechnic University, Shcherbakova T. L.
Published: December 2021

The article examines the process of interaction between tradition and innovation in the culture of textile ornament. The stability of the tradition of ornamental elements is investigated from the point of view of the ontology of an archaic society, its inextricable connection with the ritual. The process of shifting the cultural significance of the phenomenon of ornament from the sacred to the decorative is considered as a mechanism for the formation of innovations on the material of the ornament of Russian embroidery and printed pattern on fabric of the 18th — early 20th centuries.
Psychological Features of Anxiety and Motivations of Medical Personnel During the Covid-19 Pandemic
Authors:   Ural Federal University, Zinnatova M. V. , Glushkova M. S. ,   GAUZ SO SOKB 1
Published: December 2021

Medical workers, in comparison with specialists in other fields, are more susceptible to the negative impact of the current situation of the spread of coronavirus infection. The new working conditions pose a threat to the mental and psychological well-being of healthcare workers of all levels. The article presents the results of an empirical study of anxiety and motivation of nurses during the COVID-19 pandemic in relation to their assessment of the quality of life. The research was carried out based on GAUZ SO SOKB No. 1, Yekaterinburg. The sample consisted of nursing staff of the department of anaesthesiology and intensive care; the number of participants — 62 people, including 6 men and 54 women aged from 23 to 65 years. Research methods: Scale of Reactive (Situational) and Personal Anxiety” (Ch.D. Spielberger, Yu.L. Khanin); Motivation of Professional Activity (K. Zamfir, modification by A. A. Rean); the short questionnaire for the assessment of quality of life (WHOQOL). The results showed that during the COVID-19 pandemic, increased indicators of quality of life characterized nurses. It was also confirmed (but not for all indicators) that an increased level of motivation to work and a reduced level of anxiety characterize participants during the COVID-19 pandemic, with a positive assessment of the quality of life. The results obtained can be used in organizing a system of psychological support and accompanying medical workers in the process of performing professional activities in a situation of the COVID-19 pandemic.
Comparative Analysis of Personal Characteristics of Adolescents with Hearing Impaired and Adolescents Without Health Disabilities
Authors:   Ural Federal University, Tokarskaya L. V. , Cheremnih M. N. ,   Center for social and psychological assistance to children and youth "Forpost"
Published: December 2021

The article describes the results of a study of a number of personal characteristics (hardiness, coping strategies, self-regulation, and professional self-determination) in adolescents with hearing impairments and adolescents without impairments. A total of 36 male adolescents from 14 to 17 years old took part in the study. Methods were used in the work: “Modified test of hardiness by S. Maddi” (D. A. Leontiev, E. I. Rasskazova), “Questionnaire for coping with stress” (T. O. Rasskazova, E. N. Gordeeva), the questionnaire “Style of self-regulation of behavior” (V. I. Morosanova), “Five-factor personality questionnaire” (A. B. Khromov) and “Methods of studying the status of professional identity” (A. A. Azbel, A. G. Gretsov). The results obtained by all five methods were similar in the two groups of adolescents; for most of the indicators, the average level of severity was noted. Correlation analysis revealed the presence of links between the personal characteristics of adolescents with hearing impairment. The data obtained will supplement the ideas of researchers about the personal characteristics of adolescents with disabilities, and can form the basis of psycho-correctional programs designed by psychologists of educational organizations.
Satisfaction of College and University Students With Education: a Comparative Analysis
Authors:   Ural Federal University, Zborovsky G. E.
Published: December 2021

The problem of student satisfaction with secondary vocational and higher education is one of the central ones for both students and educational institutions. The social well-being of students at each university and college, their achievement of academic success largely depends on its solution. It is proved that students 'satisfaction with education affects the students' life success and their assessment of the possible results of this influence. The novelty of the material consists in a comparative study of student opinions and assessments concerning the problems of satisfaction with the received education.
How to Create an Atlas of «Silver» Professions: on the Future of «Silver» Education and the «Silver» Labour Market
Authors:   Ural Federal University, Ambarova P. A. , Stafeeva A. D. ,   Ural Federal University
Published: December 2021

The article substantiates the need to create an Atlas of «silver» professions for «young» pensioners and pre-retirees. Similar to the atlas of New Professions, it is considered as a navigator of the «third age» people in the education and labour market. The current state of «silver» education and the «silver» labour market requires the elaboration and implementation of a proactive educational and socio-labour policy capable of coordinating the trends in the development of education, the sphere of labour with the interests and needs of the older generation of Russians. The social technology of designing «silver» professions and places of employment for the «third age» people is considered, taking into account the Russian and foreign experience of using this method of social engineering.
Representation of Problems in the Field of Education in the Modern “Agenda Setting” Media of the Republic of Tatarstan
Authors:   Kazan Federal University, Bakanov R. P.
Published: December 2021

The article examines how the most popular Russian-language media among the audience of the Republic of Tatarstan talk about problems in the field of education. The author of the article used methods of problem-thematic, lexico-stylistic and comparative analysis of mass media for the previous two years (570 articles were analysed). As a result of the investigate we found the authors of the articles talked about numerous conflicts between teachers, students and their parents from an emotional point of view, wanting to increase the number of views of their articles and increase the rating of a particular media, without forming a positive media image of a teacher.
Association Between Cardiorespiratory Fitness and Healthcare Costs in Adults Using the Criterion Referenced Fitness Thresholds: The Korea Institute of Sport Science Fitness Standards Study
Authors: Lee Seunghee , Lee Hyojin , Oh In-Hwan , Cheong Hyeon-Kyoung , Lee Mihyun , Park Saejong
Published: December 2021

PURPOSE: This study aimed to determine the association between cardiorespiratory fitness (CRF) and healthcare utilization and healthcare costs in Korean adults using criterion-referenced health fitness thresholds.METHODS: The sample was drawn from the Korea Institute of Sport Science Fitness Standards Study (2014–2015) participants (n=1,780) aged 19–64 years. Participants completed a treadmill exercise test in which the peak oxygen uptake was estimated from the treadmill time. CRF thresholds were identified using receiver operating characteristic curve analysis using CRF z-scores as the test and metabolic syndrome as the criterion. The participants were categorized into low-, middle-, and high-risk groups. Healthcare utilization and healthcare costs, derived from the Korea National Health Insurance Data Sharing Service, were compared using multiple linear regression with control for body mass index (BMI), income, healthcare utilization, and healthcare costs in the previous year.RESULTS: In this study, two CRF thresholds were established: one for high sensitivity, the other for high specificity. CRF thresholds at the low-risk group were 35.2–42.6 mL/kg/min for men and 26.8–34.3 mL/kg/min for women. The total healthcare costs per participant per year for the middle- and high-risk groups were 173,016 Won and 324,840 Won, respectively, higher than those in the low-risk group after the adjustment for BMI, income, healthcare utilization, and costs in the previous year (p=.006, p<.001). The high-risk group had 2.890 visits, 3.177 visit days, and 27.215 prescription days, all of which were significantly higher than those of the low-risk group (p=.003, p=.003, p=.002).CONCLUSIONS: A low CRF is associated with higher healthcare utilization and costs. Improving CRF may result in lower healthcare utilization and costs.
Cheating interactions favor modularity in mutualistic networks
Authors: Arantes Camacho Lucas , Siliansky de Andreazzi Cecilia , P Medeiros Lucas , B Barros Irina , Emer Carine , Reigada Carolina , Guimarães Jr Paulo R
Published: December 2021

A fundamental fact about mutualisms is they are often explored by species that explore resources and services provided by individuals without providing any benefit. The role of these cheaters on the evolutionary dynamics of mutualisms has long been recognized, but cheaters may not only affect the species they explore. Because mutualisms form networks that often involve dozens to hundreds of species in a given site, indirect effects generated by cheaters may cascade through the network, reshaping trait evolution. Here, we study how harboring cheating interactions can influence coevolution in mutualistic networks. We combine a coevolutionary model, data on empirical networks of mutualisms, and numerical simulations to show that the higher frequency of cheating interactions can lead to the formation of groups of species phenotypically similar to each other but distinct from other groups of species, leading to higher trait disparity. The clustered trait patterns generated by cheaters, in turn, change the patterns of interaction in simulated networks, fostering the formation of modules of interacting species. Our results indicate that cheaters of mutualisms can contribute to generate phenotypic clusters in mutualisms, counteracting selection for convergence imposed by mutualistic patterns, and favoring the emergence of modules of interacting species.
Motivación deportiva en jugadoras de baloncesto de alto rendimiento de las selecciones nacionales de Argentina, Chile, Colombia, Ecuador, Paraguay, Perú y Venezuela
Authors: Muñoz Liliana
Published: December 2021

La motivación deportiva es un elemento esencial para el rendimiento de la actividad física y deportiva. Este estudio busca analizar los niveles de motivación desde la motivación intrínseca, extrínseca y la no motivación en 83 mujeres entre los 18 y 23 años de edad que pertenecen a la selección nacional de baloncesto de siete países latinoamericanos mediante una investigación observacional, transeccional y correlacional, en la cual se suministró la escala de motivación deportiva (SMS/EMD de Pelletier et al., 1995; Balaguer, Castillo, & Duda, 2007). Los resultados más representativos muestran que el 82.7% y 43.4% de las participantes presentaron niveles altos de motivación, intrínseca y extrínseca respectivamente. Los niveles de motivación intrínseca difieren según los países, pero no de manera estadísticamente significativa, mientras que la motivación extrínseca si varió de manera significativa entre países. También se identificó que un 13.4% de no motivación está presente en las jugadoras y que no hay diferencias significativas entre países.
Reflexiones sobre el alcance del Plan Distrital de Lectura y Escritura IED Villas del Progreso
Authors: Páez Vigoya Doris Adriana
Published: December 2021

Este artículo tiene el propósito de dar a conocer el alcance que tuvo la implementación del Plan Distrital de Lectura y Escritura -PDLE- en la ciudad de Bogotá, específicamente el proceso de intervención pedagógica realizado en la IED Villas del Progreso, ubicada en la localidad de Bosa.

El PDLE surgió en el año 2016 iniciativa, de la SED como alternativa para mejorar los procesos de lectura y escritura de los niños, y planteó acciones de intervención para los estudiantes de grado tercero en las instituciones con bajo desempeño en las Pruebas Saber de los años 2012, 2014 y 2016. A partir del desarrollo del plan de intervención y acompañamiento pedagógico, se propuso llevar a cabo una fase de diagnóstico con los estudiantes para reconocer las dificultades en habilidades comunicativas, posteriormente, revisar los objetivos propuestos a lo largo de la implementación para conocer el impacto del PDLE in situ. A partir de esta experiencia se reestructuró el plan de estudios de la asignatura de lenguaje que contribuyó a mejorar los diseños pedagógicos de los docentes y fortaleció la formación profesional atendiendo a las necesidades propias del contexto socio-cultural de la institución. En consecuencia, este artículo busca presentar los tipos de participación que se dieron en el marco de la intervención y del proyecto. De igual forma pretende valorar los alcances tanto de los procesos de formación docente como de las experiencias de aula.
VAPBr: Values in Digital Games for Public Service in Brazil
Authors: Classe Tadeu Moreira de , Janssen Fabrício , Araujo Renata
Published: December 2021

In Brazil, many initiatives have emerged to promote the dialogue between citizens and public institutions using technology. This dialogue has been a challenging endeavor, and digital games have been proposed to stimulate interaction and understanding about public service process delivery. In this context, one fundamental aspect observed for the effectiveness of these games is the human values that the games can transmit. This paper proposes the “Values at Play Brazil” (VAPBr), a deck composed of 24 cards as a brainstorming tool to help designers identify values for public process-based digital games. The paper describes the design of VAPBr and its evaluation with 14 game designers aiming to obtain participants’ perception of VAPBr capability of clearly describing values and its usefulness for identifying them for a game. Results show a positive perception of VAPBr as a brainstorming tool to discover values to be designed in a public processbased digital game.