bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of molecular subtypes and prognostic signature for hepatocellular carcinoma based on genes associated with homologous recombination deficiency
Authors: Lin Hongsheng , Xie Yangyi , Kong Yinzhi , Yang Li , Li Mingfen
Published: December 2021

Hepatocellular carcinoma (HCC) is a rapidly developing digestive tract carcinoma. The prognosis of patients and side effects caused by clinical treatment should be better improved. Nonnegative matrix factorization (NMF) clustering was performed using 109 homologous recombination deficiency (HRD)-related of HCC genes from The Cancer Genome Atlas (TCGA) database. Limma was applied to analyze subtype differences. Immune scores and clinical characteristics of different subtypes were compared. An HRD signature were built with least absolute shrinkage operator (LASSO) and multivariate Cox analysis. Performance of the signature system was then assessed by Kaplan–Meier curves and receiver operating characteristic (ROC) curves. We identified two molecular subtypes (C1 and C2), with C2 showing a significantly better prognosis than C1. C1 contained 3623 differentially expressed genes. A 4-gene prognostic signature for HCC was established, and showed a high predicting accuracy in validation sets, entire TCGA data set, HCCDB18 and GSE14520 queues. Moreover, the risk score was validated as an independent prognostic marker for HCC. Our research identified two molecular subtypes of HCC, and proposed a novel scoring system for evaluating the prognosis of HCC in clinical practice.
A novel hybrid SEIQR model incorporating the effect of quarantine and lockdown regulations for COVID-19
Authors: Prabakaran R. , Jemimah Sherlyn , Rawat Puneet , Sharma Divya , Gromiha M. Michael
Published: December 2021

Mitigating the devastating effect of COVID-19 is necessary to control the infectivity and mortality rates. Hence, several strategies such as quarantine of exposed and infected individuals and restricting movement through lockdown of geographical regions have been implemented in most countries. On the other hand, standard SEIR based mathematical models have been developed to understand the disease dynamics of COVID-19, and the proper inclusion of these restrictions is the rate-limiting step for the success of these models. In this work, we have developed a hybrid Susceptible-Exposed-Infected-Quarantined-Removed (SEIQR) model to explore the influence of quarantine and lockdown on disease propagation dynamics. The model is multi-compartmental, and it considers everyday variations in lockdown regulations, testing rate and quarantine individuals. Our model predicts a considerable difference in reported and actual recovered and deceased cases in qualitative agreement with recent reports.
Inhibition of class I HDACs preserves hair follicle inductivity in postnatal dermal cells
Authors: Park Minji , Jang Sunhyae , Chung Jin Ho , Kwon Ohsang , Jo Seong Jin
Published: December 2021

Induction of new hair follicles (HFs) may be an ultimate treatment goal for alopecia; however, functional cells with HF inductivity must be expanded in bulk for clinical use. In vitro culture conditions are completely different from the in vivo microenvironment. Although fetal and postnatal dermal cells (DCs) have the potential to induce HFs, they rapidly lose this HF inductivity during culture, accompanied by a drastic change in gene expression. This suggests that epigenetic regulation may be involved. Of the various histone deacetylases (HDACs), Class I HDACs are noteworthy because they are ubiquitously expressed and have the strongest deacetylase activity. This study revealed that DCs from postnatal mice rapidly lose HF inductivity and that this reduction is accompanied by a significant decrease in histone H3 acetylation. However, MS-275, an inhibitor of class I HDACs, preserves HF inductivity in DCs during culture, increasing alkaline phosphatase activity and upregulating HF inductive genes such as BMP4, HEY1, and WIF1. In addition, the inhibition of class I HDACs activates the Wnt signaling pathway, the most well-described molecular pathway in HF development, via increased histone H3 acetylation within the promoter region of the Wnt transcription factor LEF1. Our results suggest that class I HDACs could be a potential target for the neogenesis of HFs.
Machine learning assisted optimization of blending process of polyphenylene sulfide with elastomer using high speed twin screw extruder
Authors: Takada Shingo , Suzuki Toru , Takebayashi Yoshihiro , Ono Takumi , Yoda Satoshi
Published: December 2021

Random forest regression was applied to optimize the melt-blending process of polyphenylene sulfide (PPS) with poly(ethylene-glycidyl methacrylate-methyl acrylate) (E-GMA-MA) elastomer to improve the Charpy impact strength. A training dataset was constructed using four elastomers with different GMA and MA contents by varying the elastomer content up to 20 wt% and the screw rotation speed of the extruder up to 5000 rpm at a fixed barrel temperature of 300 °C. Besides the controlled parameters, the following measured parameters were incorporated into the descriptors for the regression: motor torque, polymer pressure, and polymer temperatures monitored by infrared-ray thermometers installed at four positions (T1 to T4) as well as the melt viscosity and elastomer particle diameter of the product. The regression without prior knowledge revealed that the polymer temperature T1 just after the first kneading block is an important parameter next to the elastomer content. High impact strength required high elastomer content and T1 below 320 °C. The polymer temperature T1 was much higher than the barrel temperature and increased with the screw speed due to the heat of shear. The overheating caused thermal degradation, leading to a decrease in the melt viscosity and an increase in the particle diameter at high screw speed. We thus reduced the barrel temperature to keep T1 around 310 °C. This increased the impact strength from 58.6 kJ m−2 as the maximum in the training dataset to 65.3 and 69.0 kJ m−2 at elastomer contents of 20 and 30 wt%, respectively.
Using dynamic time warping self-organizing maps to characterize diurnal patterns in environmental exposures
Authors: Li Kenan , Sward Katherine , Deng Huiyu , Morrison John , Habre Rima , Franklin Meredith , Chiang Yao-Yi , Ambite Jose Luis , Wilson John P. , Eckel Sandrah P.
Published: December 2021

Advances in measurement technology are producing increasingly time-resolved environmental exposure data. We aim to gain new insights into exposures and their potential health impacts by moving beyond simple summary statistics (e.g., means, maxima) to characterize more detailed features of high-frequency time series data. This study proposes a novel variant of the Self-Organizing Map (SOM) algorithm called Dynamic Time Warping Self-Organizing Map (DTW-SOM) for unsupervised pattern discovery in time series. This algorithm uses DTW, a similarity measure that optimally aligns interior patterns of sequential data, both as the similarity measure and training guide of the neural network. We applied DTW-SOM to a panel study monitoring indoor and outdoor residential temperature and particulate matter air pollution (PM2.5) for 10 patients with asthma from 7 households near Salt Lake City, UT; the patients were followed for up to 373 days each. Compared to previous SOM algorithms using timestamp alignment on time series data, the DTW-SOM algorithm produced fewer quantization errors and more detailed diurnal patterns. DTW-SOM identified the expected typical diurnal patterns in outdoor temperature which varied by season, as well diurnal patterns in PM2.5which may be related to daily asthma outcomes. In summary, DTW-SOM is an innovative feature engineering method that can be applied to highly time-resolved environmental exposures assessed by sensors to identify typical diurnal (or hourly or monthly) patterns and provide new insights into the health effects of environmental exposures.
PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation
Authors: Nyamsuren Gunsmaa , Rapp Gregor , Dihazi Hassan , Zeisberg Elisabeth M. , Tampe Desiree , Tampe Björn , Zeisberg Michael
Published: December 2021

Aryl hydrocarbon receptor nuclear translocator (ARNT) mediates anti-fibrotic activity in kidney and liver through induction of ALK3-receptor expression and subsequently increased Smad1/5/8 signaling. While expression of ARNT can be pharmacologically induced by sub-immunosuppressive doses of FK506 or by GPI1046, its anti-fibrotic activity is only realized when ARNT-ARNT homodimers form, as opposed to formation of ARNT-AHR or ARNT-HIF1α heterodimers. Mechanisms underlying ARNTs dimerization decision to specifically form ARNT–ARNT homodimers and possible cues to specifically induce ARNT homodimerization have been previously unknown. Here, we demonstrate that phosphorylation of the Ser77 residue is critical for ARNT–ARNT homodimer formation and stabilization. We further demonstrate that inhibition of PP2A phosphatase activity by LB100 enhances ARNT–ARNT homodimers both in vivo and in vitro (mouse tubular epithelial cells and human embryonic kidney cells). In murine models of kidney fibrosis, and also of liver fibrosis, combinations of FK506 or GPI1046 (to induce ARNT expression) with LB100 (to enhance ARNT homodimerization) elicit additive anti-fibrotic activities. Our study provides additional evidence for the anti-fibrotic activity of ARNT–ARNT homodimers and reveals Ser77 phosphorylation as a novel pharmacological target to realize the therapeutic potential of increased ARNT transactivation activity.
Transcriptomic and metabolic analyses revealed the modulatory effect of vernalization on glucosinolate metabolism in radish (Raphanus sativus L.)
Authors: Nugroho Adji Baskoro Dwi , Lee Sang Woo , Pervitasari Aditya Nurmalita , Moon Heewon , Choi Dasom , Kim Jongkee , Kim Dong-Hwan
Published: December 2021

Vernalization is the process by which long-term cold like winter triggers transition to flowering in plants. Many biennial and perennial plants including Brassicaceae family plants require vernalization for floral transition. Not only floral transition, but dynamic physiological and metabolic changes might also take place during vernalization. However, vernalization-mediated metabolic change is merely investigated so far. One of secondary metabolites found in Brassiceceae family plants is glucosinolates (GSLs). GSLs provides defense against pathogens and herbivores attack in plants and also exhibits inhibitory activity against human cancer cell. Profiles of GSLs are highly modulated by different environmental stresses in Brassciaceae family plants. To grasp the effect of vernalization on GSLs metabolic dynamics in radish (Raphanus sativus L.), we performed transcriptomic and metabolic analysis during vernalization in radish. Through transcriptome analysis, we found many GSLs metabolic genes were significantly down-regulated by vernalization in radish plants. Ultra-High Performance Liquid Chromatography analysis also revealed that GSLs compounds were substantially reduced in vernalized radish samples compared to non-vernalized radish samples. Furthermore, we found that repressive histone modification (i.e. H3K27me3) is involved in the modulation of GSLs metabolism via epigenetic suppression of Glucoraphasatin Synthase 1 (GRS1) during vernalization in radish. This study revealed that GSLs metabolism is modulated by vernalization, suggestive of a newly identified target of vernalization in radish.
Voltammetric detection of sumatriptan in the presence of naproxen using Fe3O4@ZIF-8 nanoparticles modified screen printed graphite electrode
Authors: Tajik Somayeh , Shahsavari Mahboobeh , Sheikhshoaie Iran , Garkani Nejad Fariba , Beitollahi Hadi
Published: December 2021

A novel electrochemical sensing platform was designed and prepared for the simultaneous detection of sumatriptan and naproxen by exploiting the prowess of the Fe3O4@ZIF-8 nanoparticles (NPs); as-synthesized Fe3O4@ZIF-8 NPs were characterized by energy-dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy (FESEM), transmission electron microscopy and thermal gravimetric analysis. The immobilized Fe3O4@ZIF-8 NPs on a screen printed graphite electrode (SPGE) was evaluated electrochemically via cyclic voltammetry, linear sweep voltammetry, and differential pulse voltammetry as well as chronoamprometery means; Fe3O4@ZIF-8/SPGE exhibited good sensing performance for sumatriptan in a range of 0.035–475.0 µM with detection limit of 0.012 µM. Also, Fe3O4@ZIF-8/SPGE exhibited good sensing performance for naproxen in a range of 0.1–700.0 µM with detection limit of 0.03 µM. The modified electrode showed two separate oxidative peaks at 620 mV for sumatriptan and at 830 mV for naproxen with a peak potential separation of 210 mV which was large enough to detect the two drugs simultaneously besides being stable in the long-run with considerable reproducibility. Real sample analyses were carried out to identify the function of fabricated electrode in sensing applications wherein trace amounts of sumatriptan and naproxen could be identified in these samples.
Geometric entanglement of a photon and spin qubits in diamond
Authors: Sekiguchi Yuhei , Yasui Yuki , Tsurumoto Kazuya , Koga Yuta , Reyes Raustin , Kosaka Hideo
Published: December 2021

Geometric nature, which appears in photon polarization, also appears in spin polarization under a zero magnetic field. These two polarized quanta, one travelling in vacuum and the other staying in matter, behave the same as geometric quantum bits or qubits, which are promising for noise resilience compared to the commonly used dynamic qubits. Here we show that geometric photon and spin qubits are entangled upon spontaneous emission with the help of the spin − orbit entanglement inherent in a nitrogen-vacancy center in diamond. The geometric spin qubit is defined in a degenerate subsystem of spin triplet electrons and manipulated with a polarized microwave. An experiment shows an entanglement state fidelity of 86.8%. The demonstrated entangled emission, combined with previously demonstrated entangled absorption, generates purely geometric entanglement between remote matters in a process that is insensitive of time, frequency, and space mode matching, which paves the way for building a noise-resilient quantum repeater network or a quantum internet.
Bottom-up/cross-linking mass spectrometry via simplified sample processing on anion-exchange solid-phase extraction spin column
Authors: Takemori Ayako , Kawashima Yusuke , Takemori Nobuaki
Published: December 2021

Capturing proteins on anion-exchange discs facilitates concentration of diluted samples and removal of contaminants, allowing more efficient sample pretreatment for bottom-up/cross-linking mass spectrometry than in-solution and in-gel.
Understanding the direct relationship between various structure-directing agents and low-temperature hydrothermal durability over Cu-SAPO-34 during the NH3-SCR reaction
Authors: Zhang Shoute , Meng Ying , Pang Lei , Ding Qianzhao , Chen Zhen , Guo Yanbing , Cai Weiquan , Li Tao
Published: December 2021

Hydrolysis of Si–O(H)–Al bonds and the loss of active Cu(OH)+ species jointly contribute towards the deactivation of Cu-SAPO-34 under a moist environment at low temperature (<100 °C).
γ-Tocotrienol induced the proliferation and differentiation of MC3T3-E1 cells through the stimulation of the Wnt/β-catenin signaling pathway
Authors: Xu Weili , Li Yutong , Feng Rennan , He Pan , Zhang Yuqi
Published: December 2021

The mechanism of γ-T3-induced proliferation and differentiation of MC3T3-E1 cells via the activation of the Wnt/β-catenin signaling pathway by allowing the stabilization and nuclear translocation of β-catenin.
Cytochrome P450 epoxygenase-derived EPA and DHA oxylipins 17,18-epoxyeicosatetraenoic acid and 19,20-epoxydocosapentaenoic acid promote BAT thermogenesis and WAT browning through the GPR120-AMPKα signaling pathway
Authors: Yang Xiaohua , Yi Xin , Zhang Fenglin , Li Fan , Lang Limin , Ling Mingfa , Lai Xumin , Chen Lin , Quan Lulu , Fu Yiming , Feng Shengchun , Shu Gang , Wang Lina , Zhu Xiaotong , Gao Ping , Jiang Qingyan , Wang Songbo
Published: December 2021

CYP epoxygenase-derived EPA and DHA oxylipins 17,18-EpETE and 19,20-EpDPE promoted BAT thermogenesis and WAT browning through the GPR120-AMPKα pathway.
Hierarchical α-MnO2nanowires as an efficient anode material for rechargeable lithium-ion batteries
Authors: Umeshbabu Ediga , Satyanarayana M. , Karkera Guruprakash , Pullamsetty Ashok , Justin P.
Published: December 2021

A simple, inexpensive and eco-friendly approach is developed toward the synthesis of large-scale production of α-MnO2nanowires by quick redox-reaction between permanganate and glycine, and are investigated as anode material for Li-ion batteries.
Vapor–liquid–solid growth and properties of one dimensional PbO and PbO/SnO2 nanowires
Authors: Kelaidis Nikolaos , Zervos Matthew , Lathiotakis Nektarios N. , Chroneos Alexander , Tanasă Eugenia , Vasile Eugeniu
Published: December 2021

Growth of PbO for energy applications and conversion of SnO2/PbO into SnO2/PbO2.
Interface engineering of heterogeneous transition metal chalcogenides for electrocatalytic hydrogen evolution
Authors: Song Ruru , Li Deyu , Xu Yafeng , Gao Junfeng , Wang Lu , Li Youyong
Published: December 2021

We report an approach of activating the basal planes of heterogeneous transition metal chalcogenides by interface engineering for electrocatalytic hydrogen evolution.
Gateway towards recent developments in quantum dot-based light-emitting diodes
Authors: Huang Yu-Ming , James Singh Konthoujam , Hsieh Tsou-Hwa , Langpoklakpam Catherine , Lee Tzu-Yi , Lin Chien-Chung , Li Yiming , Chen Fang-Chung , Chen Shih-Chen , Kuo Hao-Chung , He Jr-Hau
Published: December 2021

Here we discuss the characteristics and different synthesis approaches of QD-based LEDs for their potential applications in display and lighting technologies along with their recent breakthrough.
A centrifugal microfluidic chip for point-of-care testing of staphylococcal enterotoxin B in complex matrices
Authors: Tian Li Li , Li Chun Hong , Ye Qi Chao , Li Yuan Fang , Huang Cheng Zhi , Zhan Lei , Wang Dong Mei , Zhen Shu Jun
Published: December 2021

In this study, we utilized a centrifugal microchip platform to develop a microfluidic sensor for Staphylococcal Enterotoxin B (SEB) detection in complex matrices.
The kinetic model of cyclohexene–air combustion over a wide temperature range
Authors: Lu Hongbiao , Kong Wenhui , Zhang Changhua , Wang Jingbo , Li Xiangyuan
Published: December 2021

The model developed in this work provides a better understanding for the combustion chemistry of cyclohexene. Flux analysis gives the change of main reaction pathways under wide temperatures and different pressures.
Ligand-enabled and magnesium-activated hydrogenation with earth-abundant cobalt catalysts
Authors: Han Bo , Zhang Miaomiao , Jiao Hongmei , Ma Haojie , Wang Jijiang , Zhang Yuqi
Published: December 2021

Site-selective hydrogenation of PAHs and olefins through a Mg preactivated diketimine/CoBr2 or diketimine–Co complex.
Theoretical study on molecular mechanism of aerobic oxidation of 5-hydroxymethylfurfural to 2,5-diformyfuran catalyzed by VO2+ with counterpart anion in N,N-dimethylacetamide solution
Authors: Si Zhen-Bing , Xiong Jin-Shan , Qi Ting , Yang Hong-Mei , Min Han-Yun , Yang Hua-Qing , Hu Chang-Wei
Published: December 2021

The rate-determining reaction step is associated with the C–H bond cleavage of –CH2 group of the first HMF molecule oxidized by [V(O)2(DMA)2]+ species, while counteranion Cl− exhibits catalytically promotive effect.
Hydrogen bond activated glycosylation under mild conditions
Authors: Xiao Ke , Hu Yongxin , Wan Yongyong , Li XinXin , Nie Qin , Yan Hao , Wang Liming , Liao Jinxi , Liu Deyong , Tu Yuanhong , Sun Jiansong , Codée Jeroen D. C. , Zhang Qingju
Published: December 2021

A mild glycosylation system was developed using glycosyl imidate donors and a charge-enhanced thiourea H-bond donor catalyst. The method can be used for the effective synthesis of O-, C-, S- and N-glycosides and chemoselective one-pot glycosylation.
A highly stable membrane for vanadium flow batteries (VFBs) enabled by the selective degradation of ionic side chains
Authors: Zhao Ziming , Dai Qing , Li Xiaofeng , Zhang Suobo , Li Shenghai , Li Xianfeng
Published: December 2021

The side chains detach from the main chains of polymers, which leads to a transition of ion channels to micropores.
Sex differences in white adipose tissue expansion: emerging molecular mechanisms
Authors: Bond Simon T. , Calkin Anna C. , Drew Brian G.
Published: December 2021

The escalating prevalence of individuals becoming overweight and obese is a rapidly rising global health problem, placing an enormous burden on health and economic systems worldwide. Whilst obesity has well described lifestyle drivers, there is also a significant and poorly understood component that is regulated by genetics. Furthermore, there is clear evidence for sexual dimorphism in obesity, where overall risk, degree, subtype and potential complications arising from obesity all differ between males and females. The molecular mechanisms that dictate these sex differences remain mostly uncharacterised. Many studies have demonstrated that this dimorphism is unable to be solely explained by changes in hormones and their nuclear receptors alone, and instead manifests from coordinated and highly regulated gene networks, both during development and throughout life. As we acquire more knowledge in this area from approaches such as large-scale genomic association studies, the more we appreciate the true complexity and heterogeneity of obesity. Nevertheless, over the past two decades, researchers have made enormous progress in this field, and some consistent and robust mechanisms continue to be established. In this review, we will discuss some of the proposed mechanisms underlying sexual dimorphism in obesity, and discuss some of the key regulators that influence this phenomenon.
Analysis of symbol error rate for intelligent reflecting surface aided communications
Authors: Xu Lei , Wang Zhaorui , Chang Jing , Fang Hongyu , Li Xiaohui
Published: December 2021

The recently proposed intelligent reflecting surface (IRS) is considered as a promising technology to combat the propagation distance problem in the future communications. However, due to the lack of quantitative analysis and IRS selection scheme from the perspective of symbol error rate (SER) performance, the performance analysis method of asymptotically tight approximation SER is proposed. Firstly, a communication system model aided by an IRS is established. Then, through the reasonable reconstruction between the reflection coefficient and the link coefficient of IRS, the SNR on the forwarding link of IRS satisfies the harmonic mean form. Finally, based on the calculation method of moment generating function (MGF), the asymptotically tight approximation SER formula of the system with simple structure is derived. The simulation results show that, the asymptotically tight approximation SER formula can accurately describe the system SER performance under the low SNR condition. Before the number of IRS reflection unit increases to a certain value, the system SER performance can be effectively improved. Compared with the AF multi‐relay system, IRS aided system has the slightly better SER performance only in the case of low SNR. Our work will provide the important theoretical basis for the IRS selection in practical communications.
TDCOSMO
Authors: Van de Vyvere Lyne , Gomer Matthew R. , Sluse Dominique , Xu Dandan , Birrer Simon , Galan Aymeric , Vernardos Georgios
Published: December 2021

In the context of gravitational lensing, the density profile of lensing galaxies is often considered to be perfectly elliptical. Potential angular structures are generally ignored, except to explain flux ratios of point-like sources (i.e. flux ratio anomalies). Surprisingly, the impact of azimuthal structures on extended images of the source has not been characterised, nor has its impact on theH0inference. We address this task by creating mock images of a point source embedded in an extended source and lensed by an elliptical galaxy on which multipolar components are added to emulate boxy or discy isodensity contours. Modelling such images with a density profile free of angular structure allows us to explore the detectability of image deformation induced by the multipoles in the residual frame. Multipole deformations are almost always detectable for our highest signal-to-noise ratio (S/N) mock data. However, the detectability depends on the lens ellipticity and Einstein radius, on the S/N of the data, and on the specific lens modelling strategy. Multipoles also introduce small changes to the time-delays. We therefore quantify how undetected multipoles would impactH0inference. When no multipoles are detected in the residuals, the impact onH0for a given lens is in general less than a few km s−1Mpc−1, but in the worst-case scenario, combining low S/N in the ring and large intrinsic boxyness or discyness, the bias onH0can reach 10−12 km s−1Mpc−1. If we now look at the inference onH0from a population of lensing galaxies with a distribution of multipoles representative of what is found in the light profile of elliptical galaxies, we find a systematic bias onH0of less than 1%. A comparison of our mock systems to the state-of-the-art time-delay lens sample studied by the H0LiCOW and TDCOSMO collaborations indicates that multipoles are currently unlikely to be a source of substantial systematic bias on the inferred value ofH0from time-delay lenses.
Retrieving cosmological information from small-scale CMB foregrounds
Authors: Douspis Marian , Salvati Laura , Gorce Adélie , Aghanim Nabila
Published: December 2021

We propose a new analysis of small-scale cosmic microwave background (CMB) data by introducing the cosmological dependency of the foreground signals, focussing first on the thermal Sunyaev-Zel’dovich (tSZ) power spectrum, derived from the halo model. We analyse the latest observations by the South Pole Telescope (SPT) of the high-ℓ power (cross) spectra at 95, 150, and 220 GHz, as the sum of CMB and tSZ signals, both depending on cosmological parameters and remaining contaminants. In order to perform faster analyses, we propose a new tSZ modelling based on machine learning algorithms (namely Random Forest). We show that the additional information contained in the tSZ power spectrum tightens constraints on cosmological and tSZ scaling relation parameters. We combined for the first time the Planck tSZ data with SPT high-ℓ to derive new constraints. Finally, we show how the amplitude of the remaining kinetic SZ power spectrum varies depending on the assumptions made on both tSZ and cosmological parameters. These results show the importance of a thorough modelling of foregrounds in the cosmological analysis of small-scale CMB data. Reliable constraints on cosmological parameters can only be achieved once other significant foregrounds, such as the kinetic SZ and the cosmic infrared background (CIB), are also properly accounted for.
The v-Ball campaign at ALTO: Study for neural network based trigger for fission process
Authors: Lebois Matthieu , Jovančević Nikola , Thisse Damien , Wilson Jonathan , Canavan Rhiann , Rudigier Mathias ,   the N-SI-109 experimental team
Published: December 2021

A γ-spectroscopy campaign named “ν-Ball” was perfomed at the ALTO facility. A large fraction of the beam time was dedicated to the fast neutron induced fission of two fissioning systems: 232Th and 238U. During the data analysis, it was noticed that the high activity of the natTh was heavily contaminating any coincidence matrices (or cubes) built. This caused the identification of weakly produced fission fragments identification to be almost impossible. It was decided to explore the opportunity opened by new analysis methods based on neural networks algorithms. In this paper, the methods to build an adequate neural network and the results obtained for fission event reconstruction are presented.
Microscopic description of α-decay as super-asymmetric fission
Authors: Mirea Mihail
Published: December 2021

The fine structure of α-decay is treated with fission-like models. The single particle levels are calculated along a least action path connecting the ground state of the parent nucleus and the configuration of two spherical tangent nuclei. The probabilities to find different seniority-1 configurations are obtaining by solving the time-dependent pairing equations generalized by including the Landau-Zener effect and the Coriolis coupling. The theoretical results for the α-decay of 211Po and 211Bi are compared with experimental data showing a good agreement.
Investigation of fission product isomeric ratios and angular momenta of 132Sn populated in the 241Pu(nth,f) reaction
Authors: Nicholson Jehaan , Chebboubi Abdelhazize , Serot Olivier , Kessedjian Grégoire , Kim Yung Hee , Köster Ulli , Litaize Olivier , Méplan Olivier , Sage Christophe , Ramdhane Mourad
Published: December 2021

During an experimental campaign performed at the LOHENGRIN recoil spectrometer of the Institut Laue-Langevin (ILL), a kinetic energy dependence of 132Sn fission product isomeric ratio (IR) has been measured by inducing thermal fission of 241Pu. The IRs are deduced using gamma ray spectrometry in coincidence with the ionisation chamber. To interpret these data, we use the FIFRELIN Monte-Carlo code to simulate the de-excitation of the fission fragments. Combining the IRs with the FIFRELIN calculations, the angular momentum distribution with kinetic energy of the doubly magic nucleus of 132Sn was deduced. This will be compared with the angular momentum distribution obtained for the reaction 235U(nth,f) for 132Sn.
Systematic study of the de-excitation of neutron-rich nuclei produced in different fission reactions
Authors: Oberstedt Andreas , Gatera Angélique , Göök Alf , Lebois Matthieu , Oberstedt Stephan , Qi Liqiang , Schmitt Christelle , Wilson Jonathan N.
Published: December 2021

In this paper we present results from two recent studies, both related to the emission of prompt fissionγrays. Firstly, we have analyzed data from the reaction235U(n, f) induced by fast neutrons of average energyE̅n= 1.7 MeV. The deduced spectral characteristics are an average multiplicityM̅γ= 7.11 ± 0.44γrays per fission and an average totalγ-ray energy release in fissionE̅γ,tot= 5.51 ± 0.46 MeV, corresponding to an averageγ-ray energyɛ̅γ= 0.77 ± 0.08 MeV. Secondly, we have addressed – and answered – the question how those characteristics in general depend on the width of the chosen prompt time window and the timing resolution, determined by the employed detectors and electronics. The conclusion is that once this is known, it is possible to compare results from different experiments in a more meaningful way.
Structural effects in the production of neutrons, gammas and anti-neutrinos in fission
Authors: Schmidt K.-H. , Estienne M. , Fallot M. , Jurado B. , Schmitt C.
Published: December 2021

Structural effects in the production of light particles in fission are investigated. Most of these effects can be traced back to pairing correlations and shell effects and their dependencies on the composition of the fissioning system and its excitation energy. It is shown that the GEF code is able to reproduce most of these features and to explain their origin on the basis of established properties of nuclear matter as well as concepts and laws of general validity. Predictions for systems with scarce or no experimental information can also be made.
A mixed elasticity formulation for fluid–poroelastic structure interaction
Authors: Li Tongtong , Yotov Ivan
Published: December 2021

We develop a mixed finite element method for the coupled problem arising in the interaction between a free fluid governed by the Stokes equations and flow in deformable porous medium modeled by the Biot system of poroelasticity. Mass conservation, balance of stress, and the Beavers–Joseph–Saffman condition are imposed on the interface. We consider a fully mixed Biot formulation based on a weakly symmetric stress-displacement-rotation elasticity system and Darcy velocity-pressure flow formulation. A velocity-pressure formulation is used for the Stokes equations. The interface conditions are incorporated through the introduction of the traces of the structure velocity and the Darcy pressure as Lagrange multipliers. Existence and uniqueness of a solution are established for the continuous weak formulation. Stability and error estimates are derived for the semi-discrete continuous-in-time mixed finite element approximation. Numerical experiments are presented to verify the theoretical results and illustrate the robustness of the method with respect to the physical parameters.
Digital technologies in assessing the success component of adolescent athletes
Authors: Trofimov V.N. , Danilova A.M. , Voronin A.D.
Published: December 2021

The article suggests that the concept of “success in sports training of children” is integrative, including interrelated and correlated components. From the point of view of the authors, the evaluativeperformance component is one of the most necessary to achieve success. The authors propose to improve the indicators of this component through the trainer-child-parent interaction system, which consists in the use of digital technologies, as well as in the development and application of the educational program of interaction between the trainer and the parents of the children involved in “Success of your child”. The article also presents the diagnostics of the evaluative-effective component, which consists in testing children by using the questionnaire of Stolin. and Panteleeva. Testing was carried out in the course of experimental work in two stages: at the ascertaining stage (before the introduction of the educational program) and the control stage (after the introduction of the educational program). Based on the results of the experimental work, the authors made conclusions about the need for a deeper introduction into the practice of interaction between parents, their children and the coach.
Social control in the public administration system: digitalization context
Authors: Nikitina Alena
Published: December 2021

The article examines the theoretical, legal, and empirical aspects of social control in the public administration system in the context of digitalization. Toward the active development of the digital society, the issues of digitalization are gaining more and more popularity. The article analyzes the regulatory, financial, personnel, organizational and managerial aspects of effective social control in the public administration system based on sociological survey and experts’ interviews/ In conclusion the author offers practical digital solutions to improve the effectiveness of social control. Public administration becomes a system that is transformed by feedback from its users - citizens and depends on this feedback as a criterion for reproduction.
Development of methods for analyzing the economic activities of legal service enterprises
Authors: Parakhin Egor Viktorovich
Published: December 2021

The article reveals the features of the economic analysis of legal service enterprises. The key assets of enterprises of this type are formed by intangible assets — the competence of specialists in the field of law, their experience and reputation. For the accounting and analysis of these values, the concept of reputation-competence capital is formulated, which is considered as a set of assets of an enterprise that provides legal services, ensuring the quality of services and their competitiveness. The complexity of assessing such characteristics of service as reputation and competence leads to use of relative indicators formed by an expert and expressed in points. The analytical potential of these assessments is limited, but their formation is extremely important for management of enterprises that provide legal services, since it allows to select the optimal options for development of legal services considering the increase in intangible assets related to reputation and competence capital.
Digitalization as a resource for updating the Soviet
Authors: Skorobogatskiy V.V.
Published: December 2021

One of the topical tasks of the development of Russian society is the modernization of the public administration system, bringing the state structure in accordance with the requirements of a new social reality - the transition from an industrial to an information society. The article shows that the administrative-bureaucratic model of public administration, introduced over two decades, has been undergoing a digital transformation in recent years. The main direction of digitalization is the sphere of services that the state provides to citizens, organizations and businesses. It is noted that the usage of modern technologies does not lead to an increase in the efficiency of public administration, and its low quality becomes the main factor hindering economic growth and the formation of human capital. As a result of the study, it is concluded that the reason for the low quality of public administration and the contradictory consequences of its digitalization is that, in terms of its main characteristics, Russian society remains Soviet. The archaization of social, economic and political institutions experienced at the turn of the 1990s-2000s in line with the political course of abandoning market and democratic reforms has created a situation of institutional trap in which Russian society is today and which prevents the effective usage of new generation technologies.
“Liberal education” in the globalizing modernity in the perspective of sustainable development: the experience of philosophical interpretation
Authors: Maltsev Konstantin , Binkovskaya Larisa , Maltseva Anna
Published: December 2021

Discussion between defenders of preservation of elements of “liberal education” and those who consider it “remnants” (V. Pareto) of the “outdated” model of the “classical university” unfolds in the horizon of the “liberal consensus” regarding the “values” and “goals” of university education in the globalizing reality presented in the economic paradigm (J. Agamben). The prospect of preserving the liberal democratic tradition and the formation of civic “skills of democracy” translates the discussion into a plan of interpreting the meaning of these values and determining the conditions for ensuring their validity. A philosophical interpretation of the essence of liberal values in the context of the foundations of the economic paradigm, which presupposes external criticism, allows us to assert: the distinction between “free” and “professional” education, which is valid for the “university of reason” and has limited significance for the concept of liberal education, is removed in the modern model of the universitycorporation as an enterprise for the production of human capital and practically oriented knowledge/learning aimed at fulfilling the request market for a specialist who has mastered a variety of competencies. The concept of “sustainable development”, the constitutive of which in recent years has become the discourse of security, determines a specific explanation of “politicization” (W. Beck), one of which is the defense of “free education”, a palliative that corrects the universal and total “monocausal logic of capital” as a real beginning (in the meaning of “ἀρχή”) of global modernity presented in the liberal version of the economic paradigm.
Model of a risk-based approach in the organization of control (supervision) in the field of education
Authors: Myshko Fedor , Titor Svetlana
Published: December 2021

The risk-based approach to the organization of state control (supervision) in Russia has been implemented for about six years. At the first stage, this model of control (supervision) was implemented by 25 different supervisory agencies. With the adoption of new legislation regulating control and supervisory activities, the risk-based model has become relevant in the field of education. There is very little experience in implementing a risk-based control (supervision) model. The supervisory agency tried to formulate the principles of such a model in a recommendatory manner to regional supervisory agencies. At the moment, in accordance with the decisions of the authorities, a model of a riskoriented approach to control and supervisory activities has been formed. However, research, incl. foreign experience shows that it can and should be improved. The authors offer their own model of a risk-oriented approach when organizing control (supervision) in the field of education, based on a more differentiated consideration by the criterion of the risk of causing harm to legally protected values.
Modeling the relationship between achieving the sustainable development goals on the example of the Russian Federation
Authors: Shamaeva Ekaterina Fedorovna , Surskova Elena Sergeevna
Published: December 2021

The article is devoted to the analysis of the peculiarities of achieving the Sustainable Development Goals (SDGs) and its assessment at the national level. The Goals developed by the UN General Assembly in 2015 are a strategy to conserve economic and environmental resources, reduce inequality and meet the needs of population in the present and future realities. Importance of achieving the SDGs is due to the possibilities for improving the socio-economic situation in Russia. This paper focuses on the Sustainable Development Goal on achieving inclusive and equitable quality education and promoting lifelong learning opportunities for all (SDG4). The multilevel implementation of the Goals, as well as the complexity of its monitoring, form the need for a thorough analysis and development of approaches to assessing the SDG targets achievement. The article presents the dynamics of the Sustainable Development Goals, offers techniques for normalization and modeling the relationship of achieving the Sustainable Development Goals using correlation analysis and mentioning the methodology for constructing a regression model.
Legal status of man in the world of artificial intelligence development and sustainable development tendencies. Awareness in society
Authors: Savoschikova Evgeniya , Slyusarenko Tatiana , Alimpiyeva Tatiana
Published: December 2021

The article raises issues of balance of modern tendencies of international community development on the basis of sustainable development and Artificial Intelligence (AI) development. It also raises issues of awareness levels of sustainable development processes and AI development in accordance with the human rights and status of the individual in the modern society. The study refers to data analysis of surveys among the students of Moscow Higher Education Institutions in such specialties as Jurisprudence, Economics, State and Municipal Management, Applied Informatics, for the research of awareness levels of development of international community within the framework of sustainable development and development of AI (artificial intelligence) in the context of human rights.
Features of legal regulation of labor in the member states of the Eurasian Economic Union
Authors: Izbienova T.A. , Vaiman A.B. , Sagitov S.M.
Published: December 2021

In 2015, a new international integration economic association, the Eurasian Economic Union (hereinafter referred to as the EAEU), appeared on the economic and legal map of the world. Each member state of the EAEU, after gaining independence, as a result of the collapse of the USSR, independently formed a legislative framework in the field of labor, developed regulatory legal acts. Differences in the regulatory framework of the EAEU states, in particular, in the field of labor law, and their mutual economic integration, need to be compared in order to develop common principles, unification and harmonization of national legislation. In this regard, the article, based on the analysis of national labor legislation, assessed the prospects for regulating individual and collective labor relations and formulated conclusions on legal approaches to regulating social partnership relations, on the principles of the creation and functioning of trade unions and employers’ associations in the EAEU countries. In particular, the trade unions of the post-Soviet republics that are part of the EAEU have completely lost the right of legislative initiative, which corresponds to global practice. Currently, they can only make proposals for the adoption, amendment of regulations related to their area of competence. The position of trade unions as social partners on the adoption and amendment of labor legislation has ceased to be mandatory, and is often not taken into account by employers and public authorities.
Toucher l’interface, interfacer le toucher
Authors: Giroud Guillaume
Published: December 2021

Cet article vise à monter l’importance de l’interface dans la compréhension du toucher. Nous commencerons tout d’abord par le décrire selon une approche phénoménologique. Le toucher est spécifiquement le sens de la proximité, de la solidité, et de la forme, faisant de celui-ci le sens de la présence immédiate. Ensuite, nous montrerons que le numérique est intouchable, car d’une part, il n’est pas une chose que l’on peut saisir avec les mains, d’autre part, il est constitué de signes formels abstraits, enfin, il est inaccessible car protégé par uncopyright. Nous démontrerons alors que l’interface permet de résoudre cette difficulté. En tant quesousfaceconstituée de symboles informatiques, elle touche la couche matérielle de l’ordinateur; en tant qu’interface homme/machine, c’est-à-diresurface, elle est touchable. Nous conclurons alors que nous ne touchons pas immédiatement le numérique, et que le toucher est nécessairement médiat, remettant en cause la conception première du toucher. Nous substituerons alors au terme de toucher celui decontactqui conserve l’idée de médiation. Nous distinguerons enfin le contact opéré par l’interface homme/machine qui capture, du contact humain qui caresse, c’est-à-dire qui prend soin de maintenir autrui intouchable.
Le clip musical et l’interaction texto-visuelle par écran
Authors: Pimonova Natalia
Published: December 2021

Cet article porte sur la dimension visuelle de la chanson populaire, c’est-à-dire sur le clip musical, considéré comme l’ensemble synthétique de performances visuelle, textuelle et sociale. Les approches théoriques sont l'analyse du discours, l'analyse interactionnelle et les popular music studies. La problématique de la recherche est une marginalisation des clips musicaux sur le plan de la recherche en sciences humaines et sociales. Dans l'intention de répondre à cette problématique, nous visons à montrer comment les deux sens distaux, la vue et l'audition, contribuent aux interactions effectuées par écran et comment la perception audiovisuelle de la musique est formée. Les sensorialités écraniques sont mobilisées par les textes et les clips musicaux pour provoquer les émotions du public et transmettre le message principal d’un titre musical. L’étude porte sur l’analyse des clips vidéo des chansons sélectionnées et la distinction des catégories des moyens utilisés pour interagir avec le public et pour influencer les sens humains tels que : émoticônes, signes et couleurs, langage corporel, emprunts et nouvelles unités lexicales. Le corpus est constitué des chansons officiellement certifiées pour leurs ventes importantes et listées par le site du SNEP (Syndicat National de l’Edition Рhonographique).