bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of total skin helical tomotherapy using a 3D-printed total skin bolus
Authors: Wang Haiyang , Pi Yifei , Liu Chunbo , Wang Xin , Guo Yuexin , Lu Lei , Pei Xi , Xu Xie George
Published: June 2023

Objective

To investigate the effectiveness of using a 3D-printed total skin bolus in total skin helical tomotherapy for the treatment of mycosis fungoides.

Materials and methods

A 65-year-old female patient with a 3-year history of mycosis fungoides underwent treatment using an in-house desktop fused deposition modelling printer to create a total skin bolus made of a 5-mm-thick flexible material, which increased the skin dose through dose building. The patient's scan was segmented into upper and lower sections, with the division line placed 10 cm above the patella. The prescription was to deliver 24 Gy over 24 fractions, given 5 times per week. The plan parameters consisted of a field width of 5 cm, pitch of 0.287 and modulation factor of 3. The complete block was placed 4 cm away from the planned target region to reduce the area of the internal organs at risk, especially the bone marrow. Dose delivery accuracy was verified using point dose verification with a "Cheese" phantom (Gammex RMI, Middleton, WI), 3D plane dose verification with ArcCHECK (Model 1220, Sun Nuclear, Melbourne, FL), and multipoint film dose verification. Megavoltage computed tomography guidance was also utilized to ensure the accuracy of the setup and treatment.

Results

A 5-mm-thick 3D-printed suit was used as a bolus to achieve a target volume coverage of 95% of the prescribed dose. The conformity index and homogeneity index of the lower segment were slightly better than those of the upper segment. As the distance from the skin increased, the dose to the bone marrow gradually decreased, and the dose to other organs at risk remained within clinical requirements. The point dose verification deviation was less than 1%, the 3D plane dose verification was greater than 90%, and the multipoint film dose verification was less than 3%, all of which confirmed the accuracy of the delivered dose. The total treatment time was approximately 1.5 h, which included 0.5 h of wearing the 3D-printed suit and 1 h with the beam on. Patients only experienced mild fatigue, nausea or vomiting, low-grade fever, and grade III bone marrow suppression.

Conclusion

The use of a 3D-printed suit for total skin helical tomotherapy can result in a uniform dose distribution, short treatment time, simple implementation process, good clinical outcomes, and low toxicity. This study presents an alternative treatment approach that can potentially yield improved clinical outcomes for mycosis fungoides.
Mesoporous polydopamine delivering 8-gingerol for the target and synergistic treatment to the spinal cord injury
Authors: Yang Jinpei , Wang Meng , Zheng Shuai , Huang Ruodong , Wen Ganjun , Zhou Pan , Wang Wenbo , Zhou Shihao , Jiang Xinlin , Liu Shuangjiang , Li Zhizhong , Ma Dong , Jiao Genlong
Published: June 2023

In the treatment of spinal cord injury (SCI), the complex process of secondary injury is mainly responsible for preventing SCI repair or even exacerbating the injury. In this experiment, we constructed the 8-gingerol (8G)-loaded mesoporous polydopamine (M-PDA), M@8G, as the in vivo targeting nano-delivery platform, and investigated the therapeutic effects of M@8G in secondary SCI and its related mechanisms. The results indicated that M@8G could penetrate the blood-spinal cord barrier to enrich the spinal cord injury site. Mechanism research has shown that all of the M-PDA,8G and M@8G displayed the anti-lipid peroxidation effect, and then M@8G can inhibit the secondary SCI by suppressing the ferroptosis and inflammation. In vivo assays showed that M@8G significantly diminished the local injury area, reduced axonal and myelin loss, thus improving the neurological and motor recovery in rats. Based on the analysis of cerebrospinal fluid samples from patients, ferroptosis occurred locally in SCI and continued to progress in patients during the acute phase of SCI as well as the stage after their clinical surgery. This study showcases effective treatment of SCI through the aggregation and synergistic effect of M@8G in focal areas, providing a safe and promising strategy for the clinical treatment of SCI.
LncRNA landscape and associated ceRNA network in placental villus of unexplained recurrent spontaneous abortion
Authors: Tang Minyue , Li Qingfang , Wan Shan , Chen Qingqing , Feng Shujun , You Jiali , Wang Wei , Zhu Yimin
Published: June 2023

Background

Unexplained recurrent spontaneous abortion (URSA) is one of the most challenging conditions frustrates women of childbearing age profoundly. The gene expression patterns and biological characteristics of placental villus in patients with URSA remain largely unknown. The aim of our study was to identify potential lncRNAs as well as their action mechanisms in URSA.

Method

The ceRNA microarray was used to identify the mRNA and lncRNA expression profiles of URSA patients and normal pregnancy. Functional enrichment analyses for differentially expressed mRNAs in URSA were performed. Protein-protein interaction analysis of differentially expressed mRNAs was performed to identify hub genes and key modules. Subsequently, the co-dysregulated ceRNA network of URSA was established, and the enrichment analyses for the mRNAs in the ceRNA network was implemented. qRT-PCR was performed to validated the expression of key ENST00000429019 and mRNAs in URSA.

Results

We found that URSA placental villus have distinct mRNA and lncRNA expression profiles through ceRNA microarray, with a total of 347 mRNAs and 361 lncRNAs differentially expressed compared with controls. The functional enrichment analysis revealed that ncRNA processing, DNA replication, cell cycle, apoptosis, cytokine-mediated signaling pathway, ECM-receptor interaction were the potentially disrupted pathways in URSA patients. Then we constructed a co-dysregulated ceRNA network and found differentially expressed mRNAs were regulated by a small fraction of hub lncRNAs. Finally, we found a key network of ENST00000429019 and three cell proliferation or apoptosis related key mRNAs (CDCA3, KIFC1, NCAPH), and validated their expression and regulation in tissue and cellular levels.

Conclusions

This study identified a key ceRNA network, which might take part in URSA and correlate with cell proliferation and apoptosis. Optimistically, this study may deepen our apprehensions about the underlying molecular and biological causes of URSA and provide an important theoretical basis for future therapeutic strategies for patients with URSA.
The Prognostic and therapeutic value and clinical implications of fibroblast activation protein-α as a novel biomarker in colorectal cancer
Authors: Kalaei Zahra , Manafi-Farid Reyhaneh , Rashidi Bentolhoda , Kiani Fariba Karoon , Zarei Asieh , Fathi Mehrdad , Jadidi-Niaragh Farhad
Published: June 2023

The identification of contributing factors leading to the development of Colorectal Cancer (CRC), as the third fatal malignancy, is crucial. Today, the tumor microenvironment has been shown to play a key role in CRC progression. Fibroblast-Activation Protein-α (FAP) is a type II transmembrane cell surface proteinase expressed on the surface of cancer-associated fibroblasts in tumor stroma. As an enzyme, FAP has di- and endoprolylpeptidase, endoprotease, and gelatinase/collagenase activities in the Tumor Microenvironment (TME). According to recent reports, FAP overexpression in CRC contributes to adverse clinical outcomes such as increased lymph node metastasis, tumor recurrence, and angiogenesis, as well as decreased overall survival. In this review, studies about the expression level of FAP and its associations with CRC patients' prognosis are reviewed. High expression levels of FAP and its association with clinicopathological factors have made as a potential target. In many studies, FAP has been evaluated as a therapeutic target and diagnostic factor into which the current review tries to provide a comprehensive insight.
Mutual impact of adipocytes and colorectal cancer cells growing in co-culture conditions
Authors: Olszańska Joanna , Pietraszek-Gremplewicz Katarzyna , Domagalski Mikołaj , Nowak Dorota
Published: June 2023

Background

Colorectal cancer (CRC) is the third most common malignancy worldwide. CRC cells are situated in an adipocyte-rich microenvironment, which leads to interactions between adipocytes and CRC cells. Upon exposure to cancer cells, adipocytes transform into cancer-associated adipocytes (CAAs), and as a result, they gain features that promote tumor progression. The aim of this research was to shed more light on the detailed role of interactions between adipocytes and CRC cells associated with cancer progression in the context of these alterations.

Methods

To implement adipocyte-CRC cell interaction, a co-culture model was applied. The analyses mainly focused on the metabolic modifications within CAAs and CRC cells, as well as the proliferation and migration potential of CRC cells. The impact of CRC on adipocytes was investigated by qRT-PCR analysis and Oil Red O staining. Proliferation and migration of CRC cells upon co-culture were tested with videomicroscopy, XTT, and a wound healing assay. Metabolic changes within CAAs and CRC cells were investigated based on lipid droplet formation, cell cycle analysis, gene and protein expression by qRT-PCR, and western blotting techniques.

Results

CRC cells induced reprogramming of adipocytes into CAAs, which was connected with downregulation of lipid droplet formation in CAAs and alteration in adipocyte features. CAAs showed decreased metabolism-related gene expression, phosphorylation of Akt, ERK kinases, STAT3, and lactate secretion in comparison to the control. CAAs also promoted the migration, proliferation, and lipid droplet accumulation of CRC cells. After co-culturing with adipocytes, there was a shift to the G2/M phase of the cell cycle according to the differences in cyclin expression.

Conclusion

There are complex bidirectional interactions between adipocytes and CRC cells that may be connected with the induction of CRC cell progression.
CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability
Authors: Yang Feifei , Ma Qiang , Huang Bo , Wang Xiaolin , Pan Xiaojuan , Yu Ting , Ran Lingyu , Jiang Shan , Li Haiping , Chen Ye , Liu Yuying , Liang Ce , Ren Junwu , Zhang Yuying , Wang Shimin , Li Wei , Xiao Bin
Published: June 2023

Background

Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) is an RNA binding protein with multiple roles in regulation of gene expression at the post-transcriptional level and is implicated in tumorigenesis and progression of numerous cancers including gastric cancer (GC). Circular RNAs (circRNAs) are a diverse endogenous noncoding RNA population that have important regulatory roles in cancer. However, circRNAs that regulate the expression of IGF2BP3 in GC is largely unknown.

Methods

CircRNAs that bound to IGF2BP3 were screened in GC cells using RNA immunoprecipitation and sequencing (RIP-seq). The identification and localization of circular nuclear factor of activated T cells 3 (circNFATC3) were identified using Sanger sequencing, RNase R assays, qRT-PCR, nuclear-cytoplasmic fractionation and RNA-FISH assays. CircNFATC3 expression in human GC tissues and adjacent normal tissues were measured by qRT-PCR and ISH. The biological role of circNFATC3 in GC was confirmed by in vivo and in vitro experiments. Furthermore, RIP, RNA-FISH/IF, IP and rescue experiments were performed to uncover interactions between circNFATC3, IGF2BP3 and cyclin D1 (CCND1).

Results

We identified a GC-associated circRNA, circNFATC3, that interacted with IGF2BP3. CircNFATC3 was significantly overexpressed in GC tissues and was positively associated with tumor volume. Functionally, the proliferation of GC cells decreased significantly after circNFATC3 knockdown in vivo and in vitro. Mechanistically, circNFATC3 bound to IGF2BP3 in the cytoplasm, which enhanced the stability of IGF2BP3 by preventing ubiquitin E3 ligase TRIM25-mediated ubiquitination, thereby enhancing the regulatory axis of IGF2BP3-CCND1 and promoting CCND1 mRNA stability.

Conclusions

Our findings demonstrate that circNFATC3 promotes GC proliferation by stabilizing IGF2BP3 protein to enhance CCND1 mRNA stability. Therefore, circNFATC3 is a potential novel target for the treatment of GC.
TIMELESS upregulates PD-L1 expression and exerts an immunosuppressive role in breast cancer
Authors: Dong Xinrui , Dai Huijuan , Lin Yanping , Sheng Xiaonan , Li Ye , Wang Yaohui , Zhang Xueli , Jiang Shuheng , Yin Wenjin , Lu Jinsong
Published: June 2023

Background

Upregulation of the PD-L1 (CD274) immune checkpoint ligand on the tumor surface facilitates tumor immune escape and limits the application of immunotherapy in various cancers, including breast cancer. However, the mechanisms underlying high PD-L1 levels in cancers are still poorly understood.

Methods

Bioinformatics analyses and in vivo and in vitro experiments were carried out to assess the association between CD8+ T lymphocytes and TIMELESS (TIM) expression, and to discover the mechanisms of TIM, the transcription factor c-Myc, and PD-L1 in breast cancer cell lines.

Results

The circadian gene TIM enhanced PD-L1 transcription and facilitated the aggressiveness and progression of breast cancer through the intrinsic and extrinsic roles of PD-L1 overexpression. Bioinformatic analyses of our RNA sequencing data in TIM-knockdown breast cancer cells and public transcriptomic datasets showed that TIM might play an immunosuppressive role in breast cancer. We found that TIM expression was inversely associated with CD8+ T lymphocyte infiltration in human breast cancer samples and subcutaneous tumor tissues. In vivo and in vitro experiments demonstrated that TIM knockdown increased CD8+ T lymphocyte antitumor activity. Furthermore, our results showed that TIM interacts with c-Myc to enhance the transcriptional capability of PD-L1 and facilitates the aggressiveness and progression of breast cancer through the intrinsic and extrinsic roles of PD-L1 overexpression. Moreover, public database analysis suggested that high TIM levels were positively related to PD-L1 inhibitor therapeutic response.

Conclusions

Mechanistically, we first found that TIM could upregulate PD-L1 by interacting with c-Myc to enhance the transcriptional capability of c-Myc to PD-L1. Altogether, our findings not only provide a novel therapeutic strategy to treat breast cancer by targeting the oncogenic effect of TIM but also indicate that TIM is a promising biomarker for predicting the benefit of anti-PD-L1 immunotherapy.
Endocrine profiles and cycle characteristics of infertile 17α-hydroxylase/17,20-lyase Deficiency Patients undergoing assisted Reproduction Treatment: a retrospective cohort study
Authors: Pan Ping , Zheng Lingyan , Huang Jia , Chen Xiaoli , Ni Renmin , Zhang Qingxue , Yang Dongzi , Li Yu
Published: June 2023

Background

17α-hydroxylase/17,20-lyase deficiency (17-OHD) is a rare form of congenital adrenal hyperplasia caused by CYP17A1 gene variants. Female patients with 17-OHD demonstrate a broad clinical spectrum, including oligomenorrhea or amenorrhea and infertility, often as the sole manifestation. However, no spontaneous pregnancies in affected women have been reported.

Objective

This retrospective cohort study aimed to explore the endocrine characteristics and assisted reproductive technique (ART) performance in women with 17-OHD.

Methods

Five women were referred for primary infertility in a university-affiliated hospital over an eight-year period. The endocrine profiles and cycle characteristics during a total of nine cycles of ovarian stimulation and eight cycles of frozen-thawed embryo transfer (FET) were described in details.

Results

Three cases had homozygous variants and two cases had compound heterozygous variants, including one novel missense variant (p.Leu433Ser) in the CYP17A1 gene. Despite dual-suppression of progesterone (P) production by glucocorticoid and gonadotropin releasing hormone agonist, gradually increased P level, relatively low estradiol concentrations and thin endometrium were observed, negating fresh embryo transfer. During FET cycles, appropriate treatment resulted in low serum P levels and adequate endometrial thickness, leading to four live births.

Conclusions

Our findings demonstrate that continuous elevation of serum P during follicular growth impairs endometrial receptivity, the likely cause of female infertility in 17-OHD. Therefore, female infertility caused by 17-OHD is suggested as an indication for freeze-all strategy, with promising reproductive prognoses following segmented ovarian stimulation and FET treatment.
Adsorption of Cd (II) by a novel living and non-living Cupriavidus necator GX_5: optimization, equilibrium and kinetic studies
Authors: Li Xingjie , Xiao Qiusheng , Shao Qin , Li Xiaopeng , Kong Jiejie , Liu Liyan , Zhao Zhigang , Li Rungen
Published: June 2023

Biosorbents have been extensively studied for heavy metal adsorption due to their advantages of low cost and high efficiency. In the study, the living and non-living biomass of Cupriavidus necator GX_5 previously isolated were evaluated for their adsorption capacity and/or removal efficiency for Cd (II) through batch experiments, SEM and FT-IR investigations. The maximum removal efficiency rates for the live and dead biomass were 60.51% and 78.53%, respectively, at an optimum pH of 6, a dosage of 1 g/L and an initial Cd (II) concentration of 5 mg/L. The pseudo-second-order kinetic model was more suitable for fitting the experimental data, indicating that the rate-limiting step might be chemisorption. The Freundlich isotherm model fit better than the Langmuir isotherm model, implying that the adsorption process of both biosorbents was heterogeneous. FT-IR observation reflected that various functional groups were involved in Cd (II) adsorption: –OH, –NH, C=O, C–O and C–C groups for the living biomass and –OH, –NH, C–H, C = O, C–N and N–H groups for the dead biomass. Our results imply that non-living biosorbents have a higher capacity and stronger strength for absorbing Cd (II) than living biomass. Therefore, we suggest that dead GX_5 is a promising adsorbent and can be used in Cd (II)-contaminated environments.
Comparing leaf area index estimates in a Mediterranean forest using field measurements, Landsat 8, and Sentinel-2 data
Authors: Sebastiani Alessandro , Salvati Riccardo , Manes Fausto
Published: June 2023

Background

Leaf area index (LAI) is a key indicator for the assessment of the canopy’s processes such as net primary production and evapotranspiration. For this reason, the LAI is often used as a key input parameter in ecosystem services’ modeling, which is emerging as a critical tool for steering upcoming urban reforestation strategies. However, LAI field measures are extremely time-consuming and require remarkable economic and human resources. In this context, spectral indices computed using high-resolution multispectral satellite imagery like Sentinel-2 and Landsat 8, may represent a feasible and economic solution for estimating the LAI at the city scale. Nonetheless, as far as we know, only a few studies have assessed the potential of Sentinel-2 and Landsat 8 data doing so in Mediterranean forest ecosystems. To fill such a gap, we assessed the performance of 10 spectral indices derived from Sentinel-2 and Landsat 8 data in estimating the LAI, using field measurements collected with the LI-COR LAI 2200c as a reference. We hypothesized that Sentinel-2 data, owing to their finer spatial and spectral resolution, perform better in estimating vegetation’s structural parameters compared to Landsat 8.

Results

We found that Landsat 8-derived models have, on average, a slightly better performance, with the best model (the one based on NDVI) showing an R2 of 0.55 and NRMSE of 14.74%, compared to R2 of 0.52 and NRMSE of 15.15% showed by the best Sentinel-2 model, which is based on the NBR. All models were affected by spectrum saturation for high LAI values (e.g., above 5).

Conclusion

In Mediterranean ecosystems, Sentinel-2 and Landsat 8 data produce moderately accurate LAI estimates during the peak of the growing season. Therefore, the uncertainty introduced using satellite-derived LAI in ecosystem services’ assessments should be systematically accounted for.
Applicant qualifications and characteristics in STEM faculty hiring: an analysis of faculty and administrator perspectives
Authors: Wu Jue , Cropps Torrie , Phillips Canek Moises Luna , Boyle Samara , Pearson Yvette E.
Published: June 2023

Background

The lack of racial diversity in science, technology, engineering, and mathematics (STEM) disciplines is perhaps one of the most challenging issues in the United States higher education system. The issue is not only concerning diverse students, but also diverse faculty members. One important contributing factor is the faculty hiring process. To make progress toward equity in hiring decisions, it is necessary to better understand how applicants are considered and evaluated. In this paper, we describe and present our study based on a survey of current STEM faculty members and administrators who examined applicant qualifications and characteristics in STEM faculty hiring decisions.

Results

There are three key findings of the present research. First, we found that faculty members placed different levels of importance on characteristics and qualifications for tenure track hiring and non-tenure track hiring. For example, items related to research were more important when evaluating tenure track applicants, whereas items related to teaching and diversity were more important when evaluating non-tenure track applicants. Second, faculty members’ institutional classification, position, and personal identities (e.g., gender, race/ethnicity) had an impact on their evaluation criteria. For instance, we found men considered some diversity-related items more important than women. Third, faculty members rated the importance of qualifications with diversity, equity, and inclusion (DEI)-related constructs significantly lower than qualifications that did not specify DEI-related constructs, and this trend held for both tenure track and non-tenure track faculty hiring.

Conclusions

This study was an attempt to address the issue of diversity in STEM faculty hiring at institutions of higher education by examining how applicant characteristics are considered and evaluated in faculty hiring practices. Emphasizing research reputation and postdoctoral reputation while neglecting institutional diversity and equitable and inclusive teaching, research, and service stunt progress toward racial diversity because biases—both implicit and explicit, both positive and negative—still exist. Our results were consistent with research on bias in recruitment, revealing that affinity bias, confirmation bias, and halo bias exist in the faculty hiring process. These biases contribute to inequities in hiring, and need to be addressed before we can reach, sustain, and grow desired levels of diversity.
Recycling of cotton apparel waste and its utilization as a thermal insulation layer in high performance clothing
Authors: Bhuiyan M. A. Rahman , Ali Ayub , Mohebbullah Md. , Hossain M. Firoz , Khan Ayub Nabi , Wang Lijing
Published: June 2023

Recycling and converting  textile waste into value-added products with enhanced functional properties pave the way toward a circular economy for sustainability. This research investigates the utilization of recycled cotton fiber from apparel cutting waste for fabricating high-performance thermal barrier fabrics. The physical characterization of the developed fabrics revealed a regular arrangement of fibers, consequently the uniform thickness of the fabric with no distortion on fiber surfaces due to the recycling operation of cotton waste. The developed fabrics also demonstrated a high softness index and low compression and bending average rigidity compared to the commercial fabric with similar thickness. The heat protection performance revealed an increase in fabric conductive and radiative heat resistance with increasing the amount of recycled cotton fiber in the fabrics. The inherent thermal resistance of cotton fiber and the low inter-fiber spacing because of their uniform orientation in the fabric lead to the high thermal resistance of developed fabrics. In the case of fabric air permeability concerning the clothing thermal comfort, no significant difference in breathability was observed among the test specimens. Besides, the moisture management profile of developed fabrics indicated the capability to create favorable thermal comfort within the clothing-skin microenvironment because of improved liquid transportation and diffusion of perspiration vapor through the fabric.
Eremomastax speciosa (Hochst.): GC/MS profiling, antioxidant and antimicrobial activities of stem essential oil
Authors: Ibok Michael G. , Odeja Oluwakayode O. , Okpala Ejike O. , Eghwubare Juliet E. , Anifalaje Eniola O.
Published: June 2023

Background

Eremomastax speciosa (Hochst.) Cufod. (Acanthaceae) is a renowned medicinal plant used to ease menstrual cramps and treat female infertility, anaemia, dysentery, urinary tract infection and haemorrhoids. Essential oils and their constituents from herbs have also been utilised in the management of a good number of ailments in ethno-medicine. The chemical composition, antioxidant and antimicrobial activities of the stem essential oil are investigated in this study. The essential oil was obtained by hydro-distillation using an all-glass Clevenger apparatus. Identification and characterisation were done using Gas Chromatography–Mass Spectrometry, while antioxidant activity was evaluated with 2, 2-diphenyl-1 picrylhydrazyl radical (DPPH*) method. The antimicrobial property was assessed by the broth dilution method.

Results

The essential oil contained forty-three compounds constituting 62.87% of the total oil composition. It was dominated by non-terpene derivatives, of which (14β)-Pregnane (17.58%) is the most abundant compound. Other significant compounds identified in the essential oil include n-decane (2.3%), norbornane (2.2%), (−)-α-Copaene (1.5%), 10-epizonarene (1.5%), thymol (1.25) and (−)-α-phellandrene (1.12%). The essential oil exhibited significant antioxidant activity (IC50 0.7296 μg/mL), which is more active than the standards; vitamin C (IC50 0.8728 μg/mL) and butylated hydroxy anisole (IC50 0.8729 μg/mL) used for the assay. Also, the oil inhibited significant bacterial and fungal strains at concentrations ranging from 100 to 3.125 μg/mL with a minimum inhibitory concentration between 3.5 and 6.5 μg/mL.

Conclusion

The chemical composition of the stem essential oil of E. speciosa could be responsible for the pharmacological applications of the plant in ethno-medicine and the chemical constituent of the stem essential oil of E. speciosa is reported for the first time.

Graphical Abstract
Reply to J.M. Kolesar et al, J.S. Bates et al, and T.C. Knepper et al
Authors: West Howard (Jack) , Lovly Christine M.
Published: June 2023

Several groups provide solutions to molecular oncology support to practicing oncologists; can it scale?
Trends of research topics related to Halal meat as a commodity between Scopus and Web of Science: A systematic review
Authors: Nafik Hadi Ryandono Muhammad , Mawardi Imron , Nugraha Rani Lina , Widiastuti Tika , Tri Ratnasari Ririn , Kusuma Wardhana Akhmad
Published: June 2023

Background: People are more aware of halal products in commodity markets. Halal meat is an essential commodity for society in the Islamic commodity market in particular. The objective of this study was to analyze differences in research trends related to halal meat in published papers indexed by Scopus and Web of Science. The objective is to observe how was halal meat as commodity become the trend of research written by Indonesian authors, as well as what was the novelty of the research trend related to such tiopic.

Methods: This study used purposive sampling with a bibliometric approach in collecting the samples. The samples were published papers from the Scopus and Web of Science (SCI) databases from 2006 to 25th October 2021. The were 154 samples found from cSopus and 50 samples in Web of Science (SCI). Analysis was performed by VOSviewer and biblioshiny.

Results: Overall, 154 papers from Scopus and 50 from SCI were analyzed. Scopus and SCI exhibited different research trends. Moreover, papers from Scopus were dominated by Indonesian authors; those from SCI were not. The source growth of published papers in SCI was more dynamic than that in Scopus. The research trends in papers from SCI were more focused on the types of meat and the source itself. This was different to papers in Scopus, which placed greater emphasis on the supply chain.

Conclusions: This paper can act as a reference for continued research into halal meat in commodity markets, especially in Islamic countries. This paper is the first to compare the research trends in halal meat in the commodity market by comparing the differences in two major indexes, Scopus and SCI.
Association of PD-L1 immunoexpression with the clinicopathological characteristics and its prognostic significance in OPMD and OSCC: A cross-sectional study
Authors: Durge Shelley Rajendra , Hande Alka , Khan Samiha , Gawande Madhuri Nitin , Patil Swati K , Sonone Archana , Pakhale Aayushi
Published: June 2023

Background: Head and neck cancers stands on eighth most prevalent tumor in Oral and Maxillofacial region among which the most frequent malignant tumor is Oral Squamous Cell Carcinoma (OSCC). Worldwide 880,000 patients suffer with head and neck cancer each year, and around 440,000 die due to it. Every day the number of clinical trials is increasing and many research focuses on improved surgery, radiotherapy and also chemotherapy. The immune system, under normal conditions, functions for the protection of the host against various infectious diseases and tumours. Cell surface proteins known as "programmed cell death 1" (PD-1) and "programmed cell death ligand 1" (PD-L1) are essential for the proper functioning of immunological checkpoints. The expression of “PD-L1” positive cells has a direct correlation with poorer prognostic outcome and its correlation is inversed with CD8+T cells infiltrating tumor. This study focuses on association of “PD-L1" immunoexpression to clinicopathological characteristics and its prognostic importance in Oral Premalignant Disorder (OPMD) and OSCC.

Methods: The study included surgical tissue samples from individuals who underwent surgery for OSCC. Cases altogether, including OPMD and OSCC were chosen. Examination of sections stained with “PD-L1” antibody was done under Leica DMLB2 (Leica microscope).

Results: The present study showed significant correlation between PD-L1 immunoexpression with the clinicopathological characteristics of OPMD and OSCC cases.

Conclusions: The premalignant lesions show the intermediate “PD-L1” expression which lie between the normal or hyperplastic lesions to the OSCC. This shows a condition where there are biological adaptations has been confirmed already which directed towards malignant transformation. So, there is a crucial role of “PD-L1’ in the progression of tumor.
Case Report: Atypical presentation of non-functional gonadotropinoma
Authors: Oommen Suresh , Rice Sam
Published: June 2023

Gonadotropinoma is the most common non-functional pituitary adenoma comprising 10%–30% of all pituitary adenomas. They are benign slow-growing tumours originating from adenohypophysis and rarely become malignant. Its presentation can be atypical, such as visual disturbance, and most patients presenting to an ophthalmologist for visual correction are eventually found to have a field defect. Here, we report a case of a 59-year-old patient who presented with a left-sided visual disturbance, which progressed over the years due to a left temporal hemianopia. The patient was referred to us by an ophthalmologist and was diagnosed with a giant non-functional gonadotropinoma. The patient was surgically treated. Postoperative follow-up magnetic resonance imaging after 3 months showed near complete resection of the tumour.
Comparative evaluation of the forces produced by tongue on circummaxillary sutures in skeletal Class III malocclusion with maxillary hypoplasia using tongue crib with that of facemask therapy - A FEM study
Authors: Mathew Jeni Ann , Kamble Ranjit H , Shrivastav Sunita , Daigavane Pallavi S
Published: June 2023

Background: Class III malocclusion has the lowest incidence when compared to other malocclusions. Class III malocclusion can be present in retrognathic maxilla, prognathic mandible or a combination. Various modalities have been used in treatment. Facemask with expansion is an effective appliance used for protraction in case of retrognathic mandible; although it is effective, dentists have to deal with patient compliance. Efforts have been directed to simplify the design of appliance to redirect growth. The finite element method can be used to simulate conditions to check various hypothesis.

Methods: A finite element method (FEM) study was performed in two important steps: generation of model and model analysis. A tongue force of 4-6 pounds was applied to cribs (Group I) based on the frequency of swallowing per day (minimum to maximum). In facemask therapy (Group II), a downward force at 30 degrees along with transverse expansion of 1N was applied. Mean values of both sides were considered.

Results: Von-Mises stresses in Group I and Group II showed a non-significant difference (p=0.535). Displacement in Group I and Group II showed a significant difference (p=0.0001). Maximum amount of displacement was seen in maxillary dentition on canines and incisors, and minimum stress was seen on posterior teeth in both interventional therapies, even though the Von-Mises stresses generated were different in both groups. Overall displacement in both Group I and Group II was similar.

Conclusions: Both modalities were effective in the treatment of Class III malocclusion. The force transmission varied and overall displacement was similar in both modalities, which implies both modalities are effective in treating Class III malocclusion.
Formation of Professional Competencies Among Students of Theater Universities
Authors: Dashuk T.
Published: June 2023

The article touches upon the problems of formulating competencies in relation to creative areas of training students of higher educational institutions in educational standards. The author comes to the conclusion that the lack of clarity in the application of the competency-based approach makes the effectiveness of the entire educational process and the formation of criteria for evaluating the effectiveness of students' professionalism dependent on the teaching staff of a theater university.
Methodology for Studying the PHD Study Program in Statistical Analysis
Authors: Furaev A. , Zubarev Sergey
Published: June 2023

The article describes the content of the discipline "Methods of statistical analysis", developed for the preparation of postgraduate students of the Moscow State Academy of Physi-cal Culture in the scientific specialty 5.8.7. "Methodology and technology of vocational educa-tion". The relevance substantiated and the tasks of the discipline defined. Methods of statistical analysis that are effective for the specified specialty are given, and features of statistical pro-cessing of data from pedagogical research are noted. The specifics of the issues under consider-ation and the volume of the studied material are reflected in the main learning outcomes (to know, to be able, to master), which graduate students must demonstrate during certification in the discipline.
Socio-Cultural Design in the Preparation of Bachelors of Socio-Cultural Activities: the Experience of Branding the Kemerovo Region (Kuzbass)
Authors: Lazareva L. , Vasil'kovskaya Margarita
Published: June 2023

In the article, the authors consider the vectors of professional training of bachelors of socio-cultural activities, focused on solving the problems of consolidating the state and civil society. Socio-cultural design is the most effective technology to solve this problem.

It is noted that the curricula of universities that train bachelors of social and cultural activities include disciplines whose main educational goal is to attract student youth to socially significant activities aimed at improving living conditions, developing social activity of various population groups, as well as mastering and the preservation of national cultural values and traditions.

In the process of formation of knowledge about the history and culture of Russia and the native land among bachelors of socio-cultural activities, as well as practical participation in the development and implementation of relevant socio-cultural projects, the territory is branded. The brand of the region is defined as a territorial identity, systematically expressed in bright and attractive ideas, symbols, values, images, well-known brands of the territories of Kuzbass are also presented, which influence the quality of life and regional identity of the population of the region.
Routing buses impact analysis on the results on modeling standard digital cell on CMOS 28 nm
Authors: Il'in Sergey , Kopeykin Dmitriy , Lastochkin Oleg , Polunina Irina , Shipicin Dmitriy
Published: June 2023

In this paper, the influence of routing buses on the timing characteristics (rise/fall time and switching delay) of standard digital elements due to the manifestation of LDE and parasitic effects was studied. A set of specialized test structures to take into account such effects in layers from the first to the fourth metal was proposed. The test structures provide some of the possible cases of the relative position of the routing buses and the layout of the standard cell. Parasitic extraction and characterization of the resulting netlist were performed for each test structure. A set of netlists with parasitic parameters was characterized. It is shown that the average deviation of the temporal characteristics ranged from 1.8 to 3.9% compared to the original structure without routing buses. The largest relative deviation in switching delay is typical for the smallest load capacity, while the relative deviation of cell characteristics depends relatively weakly on the front value. On the basis of the study, recommendations were formulated for modifying the route of extraction of parasitic parameters of standard digital elements, taking into account the routing buses, in order to increase the accuracy of their modeling.
La política internacional y la agenda de género en la Argentina (2019-2023)
Authors: Deciancio Melisa , Miguez Maria Cecilia
Published: June 2023

La agenda de género ha ido permeando todas las áreas de política y cobrando relevancia a partir del trabajo constante de organizaciones que lograron la visibilización de problemáticas y desafíos. Este artículo trata sobre la interacción entre la política internacional y la agenda de género en la Argentina durante la presidencia de Alberto Fernández (2019-2023). Para ello, triangulando información recolectada de entrevistas a informantes clave, documentos oficiales y noticias, se analiza la política exterior reciente y las decisiones vinculadas con la agenda de género, así como la proyección internacional de las políticas de género implementadas en el ámbito local. Se parte de la hipótesis de que la agenda de género se abrió espacio en el ámbito de la política exterior argentina en un lapso breve, y sobre la base de la trayectoria internacional argentina vinculada con los derechos humanos y la discusión de las desigualdades en el mundo. La creación del Ministerio de Mujeres, Género y Diversidad ha sido central, pues ha proyectado al país en los debates de género global de modo institucionalizado. Si bien en algunos casos las políticas concretas son incipientes, lo que las agendas en esta doble vía demuestran es que se trata de demandas sociales profundas que han llegado al Estado para quedarse.
Sem mulheres não há saúde: o desmantelamento da política exterior de saúde pública do Brasil durante a pandemia da covid-19
Authors: Cimini Fernanda , Diana Rodrigues da Ponte Amanda , Osterno Duarte FIlho Wellington Luiz
Published: June 2023

Não é coincidência o fato de que governos de extrema direita tenham promovido políticas negacionistas durante a pandemia da covid-19 e que esses mesmos governos tenham desqualificado a luta pela igualdade de gênero em seus países, pois o campo da saúde pública é pioneiro na discussão de direitos reprodutivos e emancipação sexual feminina. O artigo analisa o caso brasileiro, explorandoas possíveis relações entre as agendas de política exterior, saúde e gênero, contrapondo os governos de centro-esquerda de Lula e Dilma, por um lado, e de extrema-direita de Bolsonaro, por outro lado. Analisa ainda o desdobramento dessa agenda no âmbito da política exterior que, durante a pandemia, resultou no desmantelamento de arranjos regionais de saúde pública em prol de uma aliança global conservadora pró-cloroquina.
Política exterior feminista en Colombia
Authors: Monroy María Catalina , Luque Rojas Andrea
Published: June 2023

Colombia oficializó la intención de diseñar e implementar una política exterior feminista (pef) el 5 de octubre de 2022. Dada la novedad del tema, en el país persisten las dudas, miedos y estigmas derivados de un profundo desconocimiento de lo que implica. En este artículo se aborda la siguiente pregunta: ¿cuáles son los antecedentes e implicaciones del anuncio de una pef en Colombia? Se reconstruyen los orígenes de la pef en gobiernos anteriores y se analizan la visión que se tiene de la implementación de una pef, los beneficios y desventajas, a quiénes incluye y excluye, y los principales desafíos. El artículo ofrece una interpretación preliminar del caso colombiano con base en el concepto de doble nivel (two-level game), el cual evidencia que cualquier alteración interna termina impactando la política internacional, y viceversa. De igual forma, se parte del feminismo en las relaciones internacionales para el análisis. Para explicar la pef colombiana, el artículo hace un rastreo (con base en fuentessecundarias y discursos) que identifica los orígenes de la pef y detalla los retos de su implementación en el gobierno de Gustavo Petro. Así, se contribuye a las discusiones sobre la implementación de estrategias de política exterior en países por fuera del “norte global”.
Scalable Computation of Dynamic Flow Problems via Multimarginal Graph-Structured Optimal Transport
Authors: Haasler Isabel , Ringh Axel , Chen Yongxin , Karlsson Johan
Published: June 2023

In this work, we develop a new framework for dynamic network flow problems based on optimal transport theory. We show that the dynamic multicommodity minimum-cost network flow problem can be formulated as a multimarginal optimal transport problem, where the cost function and the constraints on the marginals are associated with a graph structure. By exploiting these structures and building on recent advances in optimal transport theory, we develop an efficient method for such entropy-regularized optimal transport problems. In particular, the graph structure is utilized to efficiently compute the projections needed in the corresponding Sinkhorn iterations, and we arrive at a scheme that is both highly computationally efficient and easy to implement. To illustrate the performance of our algorithm, we compare it with a state-of-the-art linear programming (LP) solver. We achieve good approximations to the solution at least one order of magnitude faster than the LP solver. Finally, we showcase the methodology on a traffic routing problem with a large number of commodities.

Funding: This work was supported by KTH Digital Futures, Knut och Alice Wallenbergs Stiftelse [Grants KAW 2018.0349, KAW 2021.0274, the Wallenberg AI, Autonomous Systems and Software Program (WASP) funded by the Knut and Alice Wallenberg Foundation], Vetenskapsrådet [Grant 2020-03454], and the National Science Foundation [Grants 1942523 and 2206576].
The Career Consequences of Workplace Protest Participation: Theory and Evidence from the NFL “Take a Knee” Movement
Authors: Rheinhardt Alexandra , Poskanzer Ethan J. , Briscoe Forrest
Published: June 2023

Despite recognizing potential ramifications for employees who protest in the workplace, researchers rarely explore the career consequences that stem from such instances of workplace protest participation. We integrated research on employee activism, workplace deviance, and careers to theorize that workplace protest represents a perceived deviation from workplace norms that can influence an individual’s organizational and labor market mobility outcomes. We investigated this premise with the 2016 National Football League “take a knee” protests as a strategic research setting. The results indicate that protesting is associated with an increase in organizational exit although this effect is moderated by the degree to which the organization is sensitive to the underlying social movement (with an organization’s movement sensitivity operationalized with a four-part index composed of the team’s managers, personnel decision makers, owners, and customers). Protesting also is associated with labor market sorting across organizations as players who protest are more likely to make subsequent transitions to more movement-sensitive teams compared with players who do not protest. Overall, our findings offer contributions for research on employee activism, workplace deviance, and careers.
Setting Gendered Expectations? Recruiter Outreach Bias in Online Tech Training Programs
Authors: Lane Jacqueline N. , Lakhani Karim R. , Fernandez Roberto M.
Published: June 2023

Competence development in digital technologies, analytics, and artificial intelligence is increasingly important to all types of organizations and their workforce. Universities and corporations are investing heavily in developing training programs, at all tenure levels, to meet the new skills needs. However, there is a risk that the new set of lucrative opportunities for employees in these tech-heavy fields will be biased against diverse demographic groups like women. Although much research has examined the experiences of women in science, technology, engineering, and mathematics (STEM) fields and occupations, less understood is the extent to which gender stereotypes influence recruiters’ perceptions and evaluations of individuals who are deciding whether to apply to STEM training programs. These behaviors are typically unobserved because they occur prior to the application interface. We address this question by investigating recruiters’ initial outreach decisions to more than 166,000 prospective students who have expressed interest in applying to a midcareer level online tech training program in business analytics. Using data on the recruiters’ communications, our results indicate that recruiters are less likely to initiate contact with female than male prospects and search for additional signals of quality from female prospects before contacting them. We also find evidence that recruiters are more likely to base initial outreach activities on prospect gender when they have higher workloads and limited attention. We conclude with a discussion of the implications of this research for our understanding of how screening and selection decisions prior to the application interface may undermine organizational efforts to achieve gender equality and diversity as well as the potential for demand-side interventions to mitigate these gender disparities.

Funding: We gratefully acknowledge Harvard Business School and MIT Sloan School of Management for generously funding this work.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.16499 .