Lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase: data from the international registry "Dynamics analysis of comorbidities in SARS-CoV-2 infection survivors"
Authors: Arutyunov G. P. , Tarlovskaya E. I. , Arutyunov A. G. , Belenkov Yu. N. , Konradi A. O. , Lopatin Yu. M. , Rebrov A. P. , Tereshchenko S. N. , Chesnikova A. I. , Airapetyan G. G. , Babin A. P. , Bakulin I. G. , Bakulina N. V. , Balykova L. A. , Blagonravova A. S. , Boldina M. V. , Butomo M. I. , Vaisberg A. R. , Galyavich A. S. , Gomonova V. V. , Grigorieva N. Yu. , Gubareva I. V. , Demko I. V. , Evzerikhina A. V. , Zharkov A. V. , Zateyshchikova A. A. , Kamilova U. K. , Kim Z. F. , Kuznetsova T. Yu. , Kulikov A. N. , Lareva N. V. , Makarova E. V. , Malchikova S. V. , Nedogoda S. V. , Petrova M. M. , Pochinka I. G. , Protasov K. V. , Protsenko D. N. , Ruzanov D. Yu. , Saiganov S. A. , Sarybaev A. Sh. , Selezneva N. M. , Sugraliev A. B. , Fomin I. V. , Khlynova O. V. , Chizhova O. Yu. , Shaposhnik I. I. , Schukarev D. A. , Abdrakhmanova A. K. , Avetisyan S. A. , Avoyan O. G. , Azaryan K. K. , Aimakhanova G. T. , Aiypova D. A. , Akunov A. Ch. , Alieva M. K. , Almukhambedova A. R. , Aparkina A. V. , Aruslanova O. R. , Ashina E. Yu. , Badina O. Yu. , Barysheva O. Yu. , Batluk T. I. , Batchaeva A. S. , Bashkinov R. A. , Bitieva A. M. , Bikhteev I. U. , Borodulina N. A. , Bragin M. V. , Brazhnik V. A. , Budu A. M. , Bykova G. A. , Vagapova K. R. , Varlamova D. D. , Vezikova N. N. , Verbitskaya E. A. , Vilkova O. E. , Vinnikova E. A. , Vustina V. V. , Galova E. A. , Genkel V. V. , Giller D. B. , Gorshenina E. I. , Grigoryeva E. V. , Gubareva E. Yu. , Dabylova G. M. , Demchenko A. I. , Dolgikh O. Yu. , Duishobaev M. Y. , Evdokimov D. S. , Egorova K. E. , Ermilova A. N. , Zheldybaeva A. E. , Zarechnova N. V. , Zimina Yu. D. , Ivanova S. Yu. , Ivanchenko E. Yu. , Ilyina M. V. , Kazakovtseva M. V. , Kazymova E. V. , Kalinina Yu. S. , Kamardina N. A. , Karachenova A. M. , Karetnikov I. A. , Karoli N. A. , Karsiev M. Kh. , Kaskaeva D. S. , Kasymova K. F. , Kerimbekova J. B. , Kim E. S. , Kiseleva N. V. , Klimenko D. A. , Klimova A. V. , Kovalishena O. V. , Kozlov S. V. , Kolmakova E. V. , Kolchinskaya T. P. , Kolyadich M. I. , Kondryakova O. V. , Konoval M. P. , Konstantinov D. Yu. , Konstantinova E. A. , Kordyukova V. A. , Koroleva E. V. , Kraposhina A. Yu. , Kryukova T. V. , Kuznetsova A. P. , Kuzmina T. Yu. , Kuzmichev K. V. , Kulchoroeva Ch. K. , Kuprina T. V. , Kuranova I. M. , Kurenkova L. V. , Kurchugina N. Yu. , Kushubakova N. A. , Levankova V. I. , Ledyaeva A. A. , Lisun T. V. , Lisyanskaya V. E. , Lyubavina N. A. , Magdeeva N. A. , Mazalov K. V. , Mayseenko V. I. , Makarova A. S. , Maripov A. M. , Markov N. V. , Marusina A. A. , Melnikov E. S. , Metlinskaya A. I. , Moiseenko N. B. , Muradova F. N. , Muradyan R. G. , Musaelyan Sh. N. , Nekaeva E. S. , Nikitina N. M. , Nifontov S. E. , Obolentseva E. Yu. , Obukhova A. A. , Ogurlieva B. B. , Odegova A. A. , Omarova Yu. V. , Omurzakova N. A. , Ospanova Sh. O. , Pavlova V. A. , Pakhomova E. V. , Petrov L. D. , Plastinina S. S. , Platonov D. A. , Pogrebetskaya V. A. , Polyakov D. V. , Polyakov D. S. , Ponomarenko E. V. , Popova L. L. , Potanin A. A. , Prokofieva N. A. , Rabik Yu. D. , Rakov N. A. , Rakhimov A. N. , Rozanova N. A. , Serikbolkyzy S. , Sidorkina Ya. A. , Simonov A. A. , Skachkova V. V. , Skvortsova R. D. , Skuridin D. S. , Solovieva D. V. , Solovieva I. A. , Sukhomlinova I. M. , Sushilova A. G. , Tagaeva D. R. , Titoikina Yu. V. , Tikhonova E. P. , Tokmin D. S. , Tolmacheva A. A. , Torgunakova M. S. , Trenogina K. V. , Trostyanetskaya N. A. , Trofimov D. A. , Trubnikova M. A. , Tulichev A. A. , Tursunova A. T. , Ulanova N. D. , Fatenkov O. V. , Fedorishina O. V. , Fil T. S. , Fomina I. Yu. , Fominova I. S. , Frolova I. A. , Tsvinger S. M. , Tsoma V. V. , Cholponbaeva M. B. , Chudinovskikh T. I. , Shavrin I. V. , Shevchenko O. A. , Shikhaliev D. R. , Shishkina E. A. , Shishkov K. Yu , Shcherbakov S. Yu. , Shcherbakova G. V. , Yausheva E. A. 
Published: September 2022

Aim. To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry.

Material and methods. The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation.

Results. We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of <2,45 mmol/l is significantly worse than in patients with an LDL-C level ≥2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<1,4 mmol/l), mortality was 13,04%, which was significantly higher than in patients with LDL-C ≥1,4 mmol/l (6,32%, p=0,047).

Conclusion. A decrease in LDL-C in the acute period is significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. Determination of LDL-C can be included in the examination program for patients with COVID-19. However, the predictive value of this parameter requires further study in prospective clinical studies.