bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioinformatics Analysis and Verification of Metabolic Abnormalities in
Esophageal Squamous Carcinoma
Authors: Tang Duo , Wang Guozhen , Liu Zijia , Zheng Yu Chen , Sheng Chao , Wang Biqi , Hou Xiaonan , Zhang Yu Chen , Yao Mengfei , Zhou Zhixiang
Published: April 2023

Background:

Although esophageal carcinoma (EC) is one of the most common cancers
in the world, details of its pathogenesis remain unclear. Metabolic reprogramming is a main feature
of EC. Mitochondrial dysfunction, especially the decrease in mitochondrial complex I (MTCI),
plays an important role in the occurrence and development of EC.

Objective:

The objective of the study was to analyze and validate the metabolic abnormalities and
the role of MTCI in esophageal squamous cell carcinoma.

Methods:

In this work, we collected transcriptomic data from 160 esophageal squamous carcinoma
samples and 11 normal tissue samples from The Cancer Genome Atlas (TCGA). The OmicsBean
and GEPIA2 were used to conduct an analysis of differential gene expression and survival in clinical
samples. Rotenone was used to inhibit the MTCI activity. Subsequently, we detected lactate
production, glucose uptake, and ATP production.

Results:

A total of 1710 genes were identified as being significantly differentially expressed. The
Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analysis
suggested that these differentially expressed genes (DEGs) were significantly enriched in various
pathways related to carcinoma tumorigenesis and progression. Moreover, we further identified
abnormalities in metabolic pathways, in particular, the significantly low expression of multiple
subunits of MTCI genes (ND1, ND2, ND3, ND4, ND4L, ND5, and ND6). Rotenone was used to
inhibit the MTCI activity of EC109 cells, and it was found that the decrease in MTCI activity promoted
HIF1A expression, glucose consumption, lactate production, ATP production, and cell
migration.

Conclusion:

Our results indicated the occurrence of abnormal metabolism involving decreased mitochondrial
complex I activity and increased glycolysis in esophageal squamous cell carcinoma
(ESCC), which might be related to its development and degree of malignancy.
The Preliminary Study on Preparation Technology of PolyHb-SOD-CATCA
- The Effects of Different Extractants
Authors: Liu Rongrong , Wang Wanjun , Wang Yaoxi , Zhang Lili , Chen Gang
Published: April 2023

Introduction::

During the preparation of polyHb-SOD-CAT-CA, the lysate was extracted
by toluene. However, due to its serious toxicity and potential application in the production of
dangerous explosives, the use of toluene would likely be a restriction of the industrial development
of polyHb-SOD-CAT-CA. So, selecting other extraction reagents as alternatives to toluene is necessary
to promote the industrialization of polyHb-SOD-CAT-CA.

Aims::

The objective of this study is to investigate the application of several organic solvents extraction
during polyHb-SOC-CAT-CA preparation process, which include n-haxane and diethyl
ether, and also to compare with the existing toluene.

Methods::

After extraction with different extractants, the effects of studied organic extractant on
the stability of hemoglobin and enzymes include SOD, CAT and CA through monitoring the property
indexes include Hb concentration, MetHb content, oxygen affinity of Hb, enzymes activities
and so on.

Results::

The P50 and Hill coefficient of n-hexane group were higher than that in diethyl ether
group and toluene group. The MetHb contents, Hb recoveries and enzymes recoveries of n-hexane
group and toluene group were much better than that in diethyl ether group. The SOD activity recovery
rate in n-hexane experimental group was slightly lower than that in toluene group. However,
the CAT and CA recovery rate of n-hexane group was higher than that in toluene group.

Conclusion::

The results of this study suggested that the effects of n-hexane on the properties stability
and productivity of polyHb-SOD-CAT-CA were nearly similar with that of toluene, indicating
potential reliability and feasibility of n-hexane in the future research and development of polyHb-
SOD-CAT-CA.
Insight into the Synthesis, Biological Activity, and Structure-activity
Relationship of 1,2,4-Oxadiazole and Analogs: A Comprehensive Review
Authors: Kumar Greesh , Kumar Rajnish , Mazumder Avijit , Salahuddin  , Singh Himanshu , Kumar Upendra , Abdullah Mohd. Mustaqeem , Yar Mohammad Shahar , Kumar Neeraj
Published: April 2023

A five-membered heterocyclic compound known as 1,2,4-oxadiazole has one oxygen, two
carbon, and two nitrogen atoms within a ring. Numerous studies have shown that 1,2,4-oxadiazole has the
potential to be an essential moiety in many harmful pharmacological conditions. 1,2,4-oxadiazole and its
derivatives have been used as an antiviral, cough suppressant, vasodilator, anxiolytic, etc. To synthesize a
single molecule with potent pharmacological action, two or more pharmacophores are combined currently.
This enhances pharmacological effects, facilitates interaction possible with many targets, and reduces
the adverse effects related to them. It has been reported that synthesis of 1,2,4-oxadiazole and its analog is
possible using a variety of methods. In this present review, we emphasized recently accepted synthetic
methods for 1,2,4-oxadiazole and its analogs synthesis. Additionally, the structure-activity relationship
concerning several pharmacological effects, interactions with various targets, and the utility of different
techniques for the analysis and purification has been described. On the behalf of the above study, the
researchers can use this review study to better understand their 1,2,4-oxadiazole research in the future.
Effect of Ankle Brachial Index (ABI) and Compression Therapy on Diabetic
Foot Ulcer Healing
Authors: Burhan Asmat , Arofiati Fitri , Da Silva Vanessa Abreu , Sebayang Septian Mixrova
Published: April 2023

Purpose::

Knowing the effect of compression therapy on the value of the Ankle Brachial
Index in the healing process of Diabetic Foot Ulcer.

Design::

This study used a quasi-experimental method with pretest-posttest with control group design
with purposive sampling and non-equivalent control groups for eight weeks of treatment.

Subjects and Setting:

Patients diagnosed with Diabetic Foot Ulcer have and have Peripheral Artery
Disease, patient characteristics are homogenized, age >18 years, wound care every three days, Ankle
Brachial Index values between 0.6–1.3 mmHg, research three clinics in Indonesia in February
2021

Methods::

The population with Diabetic Foot Ulcer was screened by inclusion criteria with Ankle
Brachial Index and Bates-Jensen Wound Assessment Tool instruments, a total of n=140; in the
study, thirteen samples were excluded, the intervention group was given Compression Therapy n=
68, and the control group was compression stockings for eight weeks n=59, the data were statistically
analyzed non-parametric test using Wilcoxon and Mann-Whitney U.

Results::

Statistical analysis showed that the mean difference in paired group means was 26.4%.
Meanwhile, in the mean analysis, the difference in the post-test healing of diabetic foot ulcers was
2.83%; p=0.000 and improvement of peripheral microcirculation was 33.02%; p=0.000 in the
eighth week. Thus, compression therapy intervention in diabetic foot ulcer patients can improve
peripheral microcirculation and increase Diabetic Foot Ulcers healing compared to the control
group.

Conclusion::

Compression therapy tailored to the patient's needs and according to standard operating
procedures can improve peripheral microcirculation, so that blood flow in the legs becomes
normal; it can speed up the healing process of Diabetic Foot Ulcers.
Identification of Non-steroidal Aromatase Inhibitors via In silico and
In vitro Studies
Authors: Zafar Humaira , Anis Rabbia , Hafeez Sana , Atia-tul-Wahab  , Aqeel Khan Maria , Zehra Basha Fatima , Maslennikov Innokentiy , Choudhary Muhammad Iqbal
Published: April 2023

Introduction:

Breast cancer is the most common cancer affecting women worldwide,
including Pakistan. More than half of breast cancer patients have hormone-dependent breast cancer,
which is developed due to the over-production of estrogen (the main hormone in breast cancer).

Methods:

The biosynthesis of estrogen is catalyzed by the aromatase enzyme, which thus serves as a
target for the treatment of breast cancer. During the current study, biochemical, computational, and
STD-NMR methods were employed to identify new aromatase inhibitors. A series of phenyl-3-
butene-2-one derivatives 1-9 were synthesized and evaluated for human placental aromatase inhibitory
activity. Among them, four compounds 2, 3, 4, and 8 showed a moderate to weak inhibitory activity
(IC50 = 22.6 - 47.9 μM), as compared to standard aromatase inhibitory drugs, letrozole (IC50 =
0.0147 ± 1.45 μM), anastrozole (IC50 = 0.0094 ± 0.91 μM), and exemestane (IC50 = 0.2 ± 0.032 μM).
Kinetic studies on two moderate inhibitors, 4 and 8, revealed a competitive- and mixed-type of inhibition,
respectively.

Results:

Docking studies on all active compounds indicated their binding adjacent to the heme group
and interaction with Met374, a critical residue of aromatase. STD-NMR further highlighted the interactions
of these ligands with the aromatase enzyme.

Conclusion:

STD-NMR-based epitope mapping indicated close proximity of the alkyl chain followed
by an aromatic ring with the receptor (aromatase). These compounds were also found to be
non-cytotoxic against human fibroblast cells (BJ cells). Thus, the current study has identified new
aromatase inhibitors (compounds 4, and 8) for further pre-clinical and clinical research.
Graph Convolutional Capsule Regression (GCCR): A Model for Accelerated
Filtering of Novel Potential Candidates for SARS-CoV-2 based on Binding
Affinity
Authors: Krishnan Aravind , Vinod Dayanand
Published: April 2023

Background:

There has been a growing interest in discovering a viable drug for the new coronavirus
(SARS-CoV-2) since the beginning of the pandemic. Protein-ligand interaction studies are a crucial
step in the drug discovery process, as it helps us narrow the search space for potential ligands with
high drug-likeness. Derivatives of popular drugs like Remdesivir generated through tools employing evolutionary
algorithms are usually considered potential candidates. However, screening promising molecules
from such a large search space is difficult. In a conventional screening process, for each ligand-target pair,
there are time-consuming interaction studies that use docking simulations before downstream tasks like
thermodynamic, kinetic, and electrostatic-potential evaluation.

Objective:

This work aims to build a model based on deep learning applied over the graph structure of the
molecules to accelerate the screening process for novel potential candidates for SARS-CoV-2 by predicting
the binding energy of the protein-ligand complex.

Methods:

In this work, ‘Graph Convolutional Capsule Regression’ (GCCR), a model which uses Capsule
Neural Networks (CapsNet) and Graph Convolutional Networks (GCN) to predict the binding energy of a
protein-ligand complex is being proposed. The model’s predictions were further validated with kinetic and
free energy studies like Molecular Dynamics (MD) for kinetic stability and MM/GBSA analysis for free
energy calculations.

Results:

The GCCR showed an RMSE value of 0.0978 for 81.3% of the concordance index. The RMSE
of GCCR converged around the iteration of just 50 epochs scoring a lower RMSE than GCN and GAT.
When training with Davis Dataset, GCCR gave an RMSE score of 0.3806 with a CI score of 87.5%.

Conclusion:

The proposed GCCR model shows great potential in improving the screening process based
on binding affinity and outperforms baseline machine learning models like DeepDTA, KronRLS, Sim-
Boost, and other Graph Neural Networks (GNN) based models like Graph Convolutional Networks
(GCN) and Graph Attention Networks (GAT).
Nutritional Support System (NSS) as a New Therapeutic Strategy for Cerebral Palsy
Authors: Leal-Martinez Fernando , Jimenez Ramirez Guadalupe , Ibarra Antonio
Published: April 2023

Cerebral palsy (CP) is part of a group of nonprogressive motor disorders. The disease affects
movement and posture and constitutes the most frequent cause of motor disability in childhood.
CP is characterized by spasticity, reflecting lesions in the pyramidal pathway. Treatment is currently
focused on physical rehabilitation, and the annual progression of the disease is 2-3%. About 60% of
these patients present severe degrees of malnutrition associated with dysphagia, gastrointestinal abnormalities,
malabsorption, increased metabolism, and depression. These alterations promote sarcopenia
functional dependence and affect the quality of life and delay the evolution of motor skills. Currently,
there is evidence that the supplementation of several nutrients, dietary correction, and probiotics
can improve neurological response by stimulating neuroplasticity, neuroregeneration, neurogenesis,
and myelination. This therapeutic strategy could shorten the response period to treatment and increase
both gross and fine motor skills. The interaction of nutrients and functional foods integrating a
Nutritional Support System (NSS) has shown greater efficiency in neurological stimulation than when
nutrients are supplied separately. The most studied elements in the neurological response are glutamine,
arginine, zinc, selenium, cholecalciferol, nicotinic acid, thiamine, pyridoxine, folate, cobalamin,
Spirulina, omega-3 fatty acids, ascorbic acid, glycine, tryptophan, and probiotics. The NSS represents
a therapeutic alternative that will restore neurological function in patients with spasticity and pyramidal
pathway lesions, both characteristics of patients with CP.
Propiedades composicionales, estructurales y fisicoquímicas de las semillas de aguacate y sus potenciales usos agroindustriales
Authors: Avila Ndahita de Dios , Tirado-Gallegos Juan Manuel , Rios-Velasco Claudio , Luna Esquivel Gregorio , Estrada Virgen Mario Orlando , Cambero Campos Octavio Jhonathan
Published: April 2023

El fruto de aguacate es uno de los productos más exitosos de la producción e industrialización agroalimentaria de México. Se puede consumir fresco o procesado en una gran variedad de productos derivados. Durante su procesamiento, se generan una gran cantidad de residuos agroindustriales como la semilla del aguacate, la cual tiene componentes valiosos y con potencial de ser utilizada en diversas industrias como ingrediente en la formulación de productos funcionales. El objetivo de esta investigación fue resumir el conocimiento actual de la composición, la estructura, las propiedades y las posibles aplicaciones industriales de las semillas de aguacate y sus principales subproductos. Además, este estudio se realizó de acuerdo con la declaración Prisma, para lo cual se hizo una búsqueda bibliográfica y sistemática de artículos de investigación de los últimos 20 años en diferentes bases de datos, tomándose en cuenta diversos criterios de inclusión y exclusión. Entre los resultados, se encontró que la obtención de almidones y compuestos bioactivos a partir de la semilla de aguacate es la categoría más estudiada, siendo Nigeria, México y Estados Unidos los países con más reportes relacionados durante 2015-2020. La conclusión es que existe un creciente interés por la revalorización de las semillas de aguacate, debido a que se considera una fuente potencial de diversos componentes como vitaminas, minerales, antioxidantes, ácidos grasos saludables, carbohidratos, entre otros, y con posibles aplicaciones industriales para el desarrollo productos funcionales con valor agregado.
Caregivers’ Experiences With a Web- and Mobile-Based Platform for Children With Medical Complexity and the Role of a Live Platform Coach: Thematic Analysis
Authors: Shouldice Ainslie Claire , Beatty Madison , Adams Sherri , Dharmaraj Blossom , Moore Clara , Stinson Jennifer Nan , Desai Arti , Bartlett Leah , Culbert Erin , Cohen Eyal , Orkin Julia
Published: April 2023

Background

Children with medical complexity (CMC) are individuals with complex chronic conditions who have substantial health care needs, functional limitations, and significant use of health care. By nature of their health status, they have many care providers across multiple settings, making information sharing critical to their health and safety. Connecting2gether (C2), a web- and mobile-based patient-facing platform, was codeveloped with families to support and empower parental caregivers, improve information sharing, and facilitate care delivery. C2 also provided a live platform coach to conduct parental feedback and coaching sessions, which included answering questions, providing advice on usage, and addressing technological issues.

Objective

This study was conducted to understand the experience of parental caregivers using the C2 platform and the role of the live platform coach. This study is a subset of a larger study assessing the feasibility of C2 in the care of CMC.

Methods

Parental caregivers (n=33) participated in biweekly sessions to provide feedback and receive real-time platform use support from a trained research team member acting as a live platform coach. Parental caregivers were asked about the utility and usability of C2’s features. Questions, platform issues, and feedback were recorded on a standardized electronic data collection tool. A thematic analysis was performed to analyze parental comments, and codes were categorized into key themes. The number of comments corresponding with each code was quantified.

Results

A total of 166 parental feedback and coaching sessions were conducted, with an average of 5 sessions per parental caregiver (range 1-7). There were 33 (85%) parental caregivers that participated in at least one coaching session. Technical issues and difficulties navigating C2 were addressed in real time during the sessions to encourage platform engagement. Four key themes were identified: (1) live platform coach, (2) barriers to platform usage and technical challenges, (3) platform requests and modifications, and (4) parent partnership and empowerment.

Conclusions

Parental caregivers describe C2 as a valuable tool, acting as a facilitator for enhanced care coordination and communication. Parental caregiver feedback showed that the live platform coach was a critical tool in educating on platform use and addressing technological concerns. Further study of the use of the C2 platform and its role in the care of CMC is needed to understand the possible benefits and cost-effectiveness of this technology.
From the Cochrane Library: Interventions for Pemphigus Vulgaris and Pemphigus Foliaceus (Preprint)
Authors: Rodriguez Ramiro , Sivesind Torunn E , Murrell Dedee , Dellavalle Robert P
Published: April 2023

UNSTRUCTURED
Exploring Instagram and Facebook as tools for 22q11.2 deletion syndrome literacy (Preprint)
Authors: Silva Isabela Mayá , Lopes Vera Lucia
Published: April 2023

BACKGROUND

Health-related data available online is the most used source of information. In Brazil, more than 80% of its population uses the Internet for this purpose, particularly those diagnosed with a rare multisystem genetic disease, such as 22q11.2 Deletion Syndrome (22Q11.2 DS). This is primarily due to the lack of knowledge on the part of physicians and incomplete information received during routine consultations. However, one of the risks associated with online health data is that it lacks scientific validation.

OBJECTIVE

To improve access to trusted information, this study aims to evaluate the potential use of social media in Brazil as disseminators of scientific knowledge regarding 22q11.2 DS.

METHODS

Two social media accounts were created with the name @science.sd22q11.2, one on Instagram, and the other on Facebook

RESULTS

During the one year (2020-2021) of accounts activity, the majority of followers were females (80-90%), aged 35-44 years from Southeast (18.1%). The most frequently used words relevant to healthcare in posts with the highest reach on both pages include velopharyngeal insufficiency, speech, immunological changes, lymphocytes, and psychiatric disorders.

CONCLUSIONS

The absence of a record of followers from the North and Northeast restricts the potential use of the internet for scientific dissemination in Brazil. The low diversity of followers points to the use of the internet as a predictor of topics associated with 22q11.2 DS which deserve extra attention during medical care. Furthermore, these results serve as an additional indicator of the difficulty of accessing molecular diagnosis in association with illiteracy rates in the North and Northeast.
Fixing Flexner: Disrupting and Rebuilding Academic Medicine for Women of Color to Lead (Preprint)
Authors: Dorsey Chelsea , Arora Vineet M , Carter Keme
Published: April 2023

UNSTRUCTURED

In an effort to address the lack of compositional diversity seen in academic leadership, our generation has an opportunity to rebuild academic medicine in a way that welcomes, values, and supports the development and success of women of color.
The mediating effect of job stress between emotional intelligence and affective commitment: focusing on office workers in mid-sized enterprises and above
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Jung-Suk
Published: April 2023

Objectives The purpose of this study was to provide basic data for improvement by confirming the mediating effect of job stress between emotional intelligence and affective commitment of office workers. Methods Through a survey, data were collected from office workers in medium-sized companies and above, and the final 400 data were analyzed using SPSS 21.0 and PROCESS Macro v4.0. Results As a result of the analysis, emotional intelligence showed a negative relationship with job stress and a positive relationship with affective commitment. Job stress showed a negative relationship with affective commitment, and showed a partial mediating effect in the relationship between emotional intelligence and affective commitment. Conclusions It was confirmed that the emotional intelligence of office workers is a factor that can reduce job stress and enhance affective commitment. In addition, a partial mediating effect of job stress was confirmed in the relationship between emotional intelligence and affective commitment, confirming that emotional intelligence not only relieves job stress, but also can be a leading factor in improving affective commitment. Based on this, concrete intervention plans were suggested to reduce job stress and improve affective commitment.
Effect of Integrated Simulation Education on Nursing students’ Knowledge, Clinical performance, and Clinical reasoning competency
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Sunki , Song Uirim
Published: April 2023

Objectives This study aimed to identify the effect of Integrated simulation(virtual reality simulation with high-fidelity simulation) education on nursing students’ knowledge, clinical performance, and clinical reasoning competency. A single group pre-post quasi-experimental design was used. Methods Data were collected from November 2021 to December 2021. Nursing knowledge, clinical performance ability, and clinical reasoning competency scores were analyzed from the learning evaluation data of 67 students before and after the integrated simulation class. Data were analyzed by Wilcoxon signed rank test using IBM SPSS 23.0 since the normality test was not satisfied. Results The results indicated that the group that participated in the integrated simulation education program had significantly higher nursing knowledge (z=6.201, p<.001), clinical performance (z=4.999, p<.001) and clinical reasoning competency (z=6.616, p<.001) compared to the pre-test. Conclusions The results of this study can be used as basic data for developing educational programs that can enhance existing simulation classes and improve nursing knowledge, clinical performance, and clinical reasoning capabilities.
Analysis of awareness and demand for new nurses' core competency skill education program using IPA technique
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Choi Hyoung-Ju , Kim Mi-Hee , Lim Ji-Hyang
Published: April 2023

Objectives This study was to analyze new nurses and preceptors' awareness of new nurses' core competency skills education program, and the degree of demand through the importance, satisfaction, and performance of each target. Methods A paired-sample t-test was conducted for each subject's factors and items through data collected through questionnaires to find out the importance, satisfaction, and performance of new nurses and preceptors, who are research subjects for the new nurses' core competency skills education program. Using the IPA technique, it was schematized as an IPA Matrix, and the distribution status by factor and item of each subject was analyzed. Results 1. Results of analysis of importance and satisfaction of new nurses' core competency skills education program. As a result of difference analysis on importance and satisfaction of 6 factors, as a result of difference analysis on importance and satisfaction by 3 factors and 34 items, 19 items showed statistically significant differences. 2. Results of IPA analysis of new nurses' core competency skills education program. In the area of continuous maintenance, the professionalism of the instructor was included among the six factors, and in the area of intensive improvement and management, the educational program and educational environment were included among the six factors. 3. Results of analysis of the importance and performance of the preceptor's nursing job. As a result of analyzing the difference in importance and performance of 16 factors of nursing job, 14 factors showed statistically significant differences, and in most factors, the importance was higher than the performance. There was a statistically significant difference in importance and performance in 38 out of 51 nursing job items, and most of ‘performance’, which showed high importance, showed a difference. 4. Results of the IPA analysis on the nursing job of the preceptor. Among the 16 factors, assessment, performance, communication, and cooperation were included in the continuous maintenance area, and no factors were applicable in the intensive improvement and management area. Four items of performance factors were included in the second quadrant, which means that the actual performance falls short of the job that nurses consider important. Conclusions Based on the analysis results of this study, the difference in education satisfaction of core competency skills recognized as important by new nurses and the causes of differences in importance and performance according to nursing duties among preceptors were identified, and these were identified in the education program for new nurses. By applying it, new nurses will prepare the foundation for fully practicing the core competency of nurses.
The Meaning and Needs of Early Childhood Mathematics Education Recognized by Mothers of 5-Year-Old Children
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, YI SAIM
Published: April 2023

Objectives The purpose of this study was to find out the current status and difficulties of mathematics education guidance for mothers aged 5 years old, and to explore the meaning of mathematics education and mothers' needs for mathematics education. Methods To this end, 10 mothers of 5-year-old infants living in Seoul were selected as study participants. Data collection was conducted through in-depth personal interviews. In-depth interviews were conducted over a total of two sessions. For data analysis, the interview contents were repeatedly read, coded for each topic, and triangular verification was conducted by two early childhood education experts. Results Mothers of 5-year-olds recognized the purpose of early childhood mathematics education as preparation for elementary school. As a method of math education, it was found that play-type math education using play, math fairy tales, and games in daily life, and math education that relies on private education such as visiting study materials and math institutes. In the process of doing homework for the study paper, mothers wanted to form learning attitudes and habits, but some infants experienced stress. And mothers feel confused about math, thinking, and storytelling math. It was recognized that literacy should be the basis for mathematics education. When providing math education, mothers were found to be based on math subjects in the first grade of elementary school and to have a prior study of about a year. For desirable math education, mothers required specific guidance on the level and content of early childhood math education, information on math education in kindergartens, and cooperation between infants, parents, and teachers for math education. Conclusions This study is meaningful in that it suggested the direction for early childhood mathematics education by grasping the meaning, practice, and difficulties of education recognized by mothers.
Longitudinal study of extracurricular educational performance outcomes for student empowerment: Focusing on learning support programs
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Na Mi-Hyeon
Published: April 2023

Objectives The purpose of this study is to provide basic data that can be continuously used for educational performance evaluation by exploring variables that affect non-subject educational performance, and to suggest ways to strengthen student capacity. Methods Literature analysis on non-subject educational achievements, 4-year non-subject webpages were searched, and related university evaluation certification data were analyzed. In addition, repeated measures variance analysis and hierarchical multiple regression analysis were conducted according to the research problem based on the mileage score, number of program participation, GPA, and core competency diagnosis score of students who participated in the learning support program conducted by K University in Gyeonggi-do for 3 years. to verify the difference and effectiveness by year. Results As a result of analyzing whether there is a difference in GPA and core competency scores by year, the number of program participation has no effect on GPA and core competency scores. 21 to 33 hours of participation improves professional competency, and 68 hours or more of communication competency improves. The order of influence on the 2018 GPA score is the 2017 GPA score, female student, and mileage score of 680 or higher. The core competency score in 2018 has a significant effect on the diagnosis score in 2017, and professional competency improves when 13 to 15 programs participate. Conclusions It is meaningful in that it verifies the effectiveness of non-subject programs through practical data, such as the certification scores awarded by each university and the number of program participants, and prepares basic data for analyzing educational performance. Based on the results of the study, plans for strengthening student capabilities and limitations of the study were presented.
Socioscientific issues in science exhibitions: examining contributions of the informal science education sector
Authors: Navas Iannini Ana Maria
Published: April 2023

This paper examines how a particular subset of informal science education settings — science exhibitions — embraces contemporary socioscientific issues (SSI) and fosters public engagement with them. A qualitative cross-case analysis of two SSI exhibitions about teen pregnancy (Brazil) and sustainability (Canada) was conducted. It revealed complex issues around operational funding, and institutional tensions related to the nature, balance, and relevance of the topics displayed. The analysis unravelled opportunities for SSI exhibits to engage with contextualized and situated knowledge; articulate the deficit model with other models of science communication; and consider visitors as agents of change.
O. Wilde and Russia: The Issues of Poetics and Reception
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences
Published: April 2023

Collection of articles “O. Wilde and Russia: Problems of Poetics and Reception” is a collective work of researchers of the creativity of the English writer, who set out to look at his legacy taking into account the latest data on his biography, literary and cultural ties. The central scientific problem of this book is the writer’s attitude to Russia, its literature, philosophical and socio-political thought, as well as the ways and contexts of understanding his work in the Russian Empire, the USSR and post-Soviet Russia. Analysis of this bidirectional reception allows us to conclude that Wilde has learned much more from Russian culture than it was previously thought. On the other hand, for more than a hundred years the writer’s artistic world, his aesthetic and philosophical ideas have been correlated with the most important and urgent problems in Russian literature, history and social thought. Through the admiration and creation of a biographical myth, through the borrowing of images, motifs, stylistics and specific literary techniques, despite the controversy, denial, censure and oblivion, thanks to the rediscovery and re-reading of his works the process of cultural enrichment and development has always been going on.
O. Wilde’s Fantasies on Russian Theme in English Style (“Vera; or, The Nihilists”)
Authors:   Oles Honchar Dnipro National University, Potnitseva Tatiana N.
Published: April 2023

The article focuses on the first play by O. Wilde, which got investigators’ undeserved mark as “an imperfection of the first pen attempt”. Meanwhile, as the analysis confirms, the parody and farcical manner of this work of art, which had the signs of Wilde’s future recognizable style, gave birth to the brilliant travesty of “the cloak and sword drama” production. But for its caustic satire and ironic presentation the playwright turned to the plot about Russian conspirators and Russian anarchism. This plot was prompted both by the modern time and by the works of Russian classical writers. Among them — “Fathers and Children” by I. Turgenev and “Demons” by Dostoyevsky — the books Wilde read and used as an ironic background. The parody and farcical, grotesque manner of Wilde’s first play is revealed due to the endless allusions, references, reminiscences, a play on words, word forms, locations, and choice of names, colour symbolism, and the forming decorative style. In the history of the Russian nihilists’ conspiracy — a kind of “demons’ coven” — the author of “Vera…”, as the work convinces, combined a lot of what he had learnt from the Russian literature and from what the creation of his own imagination was. The very word “nihilism” became in his work a key one, a conceptual centre. And the Wilde’s nihilists appear as a generalized image of any despotic ideology unnatural to human relations.
O. Wilde’s Social Philosophy and its Reception in Russia at the Beginning of the 20th Century
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Markova Ekaterina А. ,   Peoples’ Friendship University of Russia
Published: April 2023

The article deals with the issue of the influence of P. Kropotkin’s anarchism on the development of O. Wilde’s social philosophy. The assumption is made about a possible reverse influence (based on some similarities between Wilde’s interpretation of individualism and that of Kropotkin). Another issue discussed in the article is the reception of Wilde’s socialism (The Soul of man Under Socialism) in Russia. The sources of this reception are the works of some prominent writers, poets, literary critics and philosophers of the beginning of the 20th century (K.D. Balmont, A. Bely, N.A. Berdyaev, M.L. Gofman, A.I. Tinyakov, S.L. Frank, K.I. Chukovsky). Their criticism is focused on Wilde’s treatment of individualism, which is key to his socialism. Wilde’s individualism is perceived in the context of the discussion around individualism and conciliarity (‘sobornost’). The object of some criticism is Wilde’s interpretation of Christ and his individualism. Other critics link Wilde’s socialism with his estheticism. Some criticism is aimed at Wilde’s particular ideas and opinions (his understanding of technological progress and its consequences for society, as well as his interpretation of socialism itself).
O. Wilde and A. Mire: Creative Parallels
Authors:   Lomonosov Moscow State University, Mikhailova Maria V. ,   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kudritskaya Sofya V. ,   Lomonosov Moscow State University
Published: April 2023

The article examines the works of two writers of the same era — Oscar Wilde and Mire (Alexandra Mikhailovna Moiseeva, 1874–1913). It focuses mainly on Mire’s two reviews written on the occasion of the posthumous publication of Wilde’s works, which directly indicate the connections between the two writers. In the views, Mire provides her own viewpoint on Wilde’s crime, guilt and punishment that are associated with the trial during the last years of his life, and reads “De Profundis” in this context. Attention is also paid to Mire’s story “The Black Panther”, the plot of which refers to the vicissitudes in the last years of Wilde’s life. The story could be considered a free interpretation and neomythological transformation of biographical facts. Thematic similarities in other works of Wilde and Mire are revealed by the analysis of two nomadic recurring images — panther and peacock. Parallels are found in Mire’s short stories “The Spring Night”,“The Hermit” and Wilde’s fairy tale “The Fisherman and His Soul” and his poem in prose “The Teacher of Wisdom”.
“The Man of the Universe Enclosed in Dandy’s Tuxedo…”: The Image of Oscar Wilde in the Poetic Assessment of Igor-Severyanin
Authors:   Moscow University of Finance and Law, Nikultseva Victoria V.
Published: April 2023

In this paper, a linguopoetic analysis of the poems of Igor-Severyanin dedicated to the memory of O. Wilde, containing an assessment of the life and work of the English writer, is made. Feeling like a double of an aesthete with a scandalous fame, young Igor-Severyanin follows the principles of dandyism and self-promotion which tendency is reflected in his early poetry. The article deals with an analysis of Igor-Severyanin’s sonnet “Oscar Wilde. Asso-sonnet” (1911). A composition, a system of images, a level of ideas and subjects are regarded via the analysis of the next language levels: lexico-semantic, phonetic, grammatical. Without any doubt from the point of view of stylistics a set of expressive devices used by the author in his writings is interesting for the researcher of poetic texts.
The Image of Oscar Wilde in the Soviet Cultural Consciousness of the 1920s and 1930s
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Chechnev Yakov D.
Published: April 2023

The choice of the research topic is explained by the need to fill in the gap in the studies about Wilde’s reception in the USSR in the 1920–1930s. The aim of the study is to show the main lines of reception of the Anglo-Irish writer in the Soviet Union. The principal focus is not on Wilde’s works per se, but on the way his name was used by representatives of the Soviet culture of the 1920s and 1930s. Wilde’s readers can be divided into admirers and detractors, to achieve their goals. The author of the article shows that Wilde’s name appeared in everyday life and on book lists in the leading periodicals of the USSR — the newspapers “Pravda” and “Izvestia”. Through the images created by the writer, everyday life and urban paintings were comprehended. Wilde’s aphorisms were used not only by his admirers, but also by his antagonists, to illustrate their ideas and reinforce certain propositions. In the 1930s, the negative attitude towards the writer intensified. The Anglo-Irish writer was perceived by critics as a representative of “bourgeois” society. His image, which was formed largely thanks to the Russian modernists, embodied the main vices of the West: sexual perversions, excessive aestheticism, inattention to social aspects of art. In the 1930s, Wilde became a part of an episode of controversy surrounding a new socialist method — social realism and accelerated the death of the peasant poet P. Oreshin. The author of the article comes to the conclusion that for two decades after the establishment of Soviet power Wilde was still relevant in the cultural consciousness of Soviet society, however, by the beginning of the 1930s his name was tabooed.
Oscar Wild in The Works by Kenneth Grahame: From “Pagan Papers” to “The Wind in the Willows”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Veligorsky Georgy A.
Published: April 2023

In this article, we will consider the parallels between the works of Oscar Wilde and Kenneth Grahame, determine the mutual influence of these writers, the common origins of their creative ideas and the roots of aesthetic philosophy (the works of J. Ruskin, W. Pater, the “Pre-Raphaelite brotherhood”), and try to trace how legitimate it is to draw the corresponding parallel between them. We will pay special attention to the image of Mr. Toad, the character of Grahame’s tale “The Wind in the Willows”, which, according to many researchers, reflected the features of Wilde — features of his appearance and character, worldview, tastes (primarily aesthetic) and behavior. Separately, we will analyze the scene from Chapter VI of “The Winds in the Willows” — the trial of Mr. Toad, in which researchers see a reminiscence (if not a parody) of the famous trial of Wilde. Having compared the key facts and summarizing all the main developments of researchers that exist today, we will trace how viable this emerging parallel is and whether the contingence itself, on the one hand, of these two writers, and on the other, Oscar Wilde and Mr. Toad, the hero a Grahame’s tale really takes place.
The Metamorphoses of Tradition in О. Wilde’s Comedies: Between the Comedy of Manners and the “Well-made Play”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Chesnokova Tatiana G.
Published: April 2023

The variety of literary links and the lines of succession connecting Wilde’s comedies with the past and the future seem to be one of the truisms of Wildean studies. On the level of their formal structure Wilde’s comedies were influenced, in particular, by the English 17–18 centuries’ comedy of manners as well as the 19 century melodrama (including its manifestations in the works of the authors associated with the so-called “wellmade play”). Melodramatic elements in Wilde’s dramatic oeuvres are balanced (and partly neutralised) by those of “pure” comedy, while in the last (and the most brilliant) of his plays of the 1890s ― “The Importance of Being Earnest” ― they totally fade away. The features of both “witty” comedy of manners and sentimentally coloured melodrama, being repeatedly found in Wilde’s “society” drama, become still more dazzling if one compares his chosen comedies with the texts representative of each of the named genre models and containing the complex of motifs later used by Wilde in one of his “society” plays. In the article the above mentioned task is solved through comparative studies of Wildean comedy “Lady Windermere’s Fan” and the drama by V. Sardou “Odette”, linked with the former by shared motifs, as well as of the comedies by H. Fielding “The Modern Husband” and Wilde “An Ideal Husband” also demonstrating some plot parallels. The comparison contributes to the clarification of the role played by comedy and melodrama (especially in their interrelation) in the process of realization of the Wildean aestheticism artistic program in his works of the early and mid-1890s.
Optimized hill climbing algorithm for an islanded solar photovoltaic system
Authors: Awan Muhammad Mateen Afzal , Khan Atif Ullah , Siddiqui Mohammad Umer , Karim Hamid , Bux Muhammad
Published: April 2023

Conventional energy generation technologies face unreliability due to the depletion of fossil fuels, soaring energy prices, greenhouse gas emissions, and continuously increasing energy demand. As a result, researchers are searching for reliable, cheap, and environmentally friendly renewable energy technologies. Solar photovoltaic (PV) technology, which directly converts sunlight into electricity, is the most attractive sustainable energy source due to the sun's ubiquitous presence. However, the non-linear behaviour of solar PV demands maximum power point tracking (MPPT) to ensure optimal power production. Although Hill Climbing (HC) is a simple, cheap, and efficient MPPT algorithm, it has a drawback of steady-state oscillations around MPP under uniform weather conditions. To overcome this weakness, we propose some modifications in the tracking structure of the HC algorithm. The proposed optimized HC (OHC) algorithm achieves zero steady-state oscillations without compromising the strength of the conventional HC algorithm. We applied both algorithms to an off-grid PV system under constant and changing weather conditions, and the results demonstrate the superiority of the proposed OHC algorithm over the conventional HC algorithm.
Optimization and efficiency analysis of deep learning based brain tumor detection
Authors: Saeed Maryam , Halepoto Irfan Ahmed , Khaskheli Sania , Bushra Mehak
Published: April 2023

Brain tumors are spreading very fast across the world. It is one of the aggressive diseases which eventually lead to death if not being detected timely and appropriately. The difficult task for neurologists and radiologists is detecting brain tumor at early stages. However, manually detecting brain tumor from magnetic resonance imaging images is challenging, and susceptible to errors as experienced physician is required for this. To resolve both the concerns, an automated brain tumor detection system is developed for early diagnosis of the disease. In this paper, the diagnosis via MRI images are being done along with classification in terms of its type. The proposed system can specifically classify four brain tumor condition classification like meningioma tumor, pituitary tumor, glioma tumor and no tumor. The convolutional neural network method is used for classification and diagnosis of tumors which has accuracy of about 93.60%. This study is done on a KAGGLE dataset which comprises of 3274 Brain MRI scans. This model can be applied for real time brain tumor detection.
Inhibitory Effect of Verjuice Against Some Dental Decay Bacterial Species
Authors: AlhamedAlduihi Hiba , Rawal Mahmoud , Khatib Chadi
Published: April 2023

People in most countries suffer from tooth decay due to various reasons, and the germs responsible for tooth decay show an increase in resistance towards standard antibiotics used in treatment because of the inappropriate and indiscriminate use of these antibiotics. This study aimed to search for natural products that have fewer side effects and are more effective for treatment. Natural verjuice was used to study its effectiveness against some bacterial species including Escherichia coli, Streptococcus mutans, Staphylococcus aureus, and Pseudomonas aeruginosa that cause caries, which were obtained from the Microbiology Research Laboratory in a previous study. The results showed the superiority of the effectiveness of verjuice over the effectiveness of most of the selected antibiotics against the studied bacteria, which confirms its effectiveness as a natural product without the need to extract the active substances with organic solvents.