bluuebunny/crossref_metadata_2025 huggingface dataset:
APPLICATION OF CLUSTER ANALYSIS IN SMART GRID NETWORKS
Authors: Yagup Kateryna
Published: January 2023

The task of developing and improving intelligent multi-agent control systems, which provide opportunities for intelligent online analysis of the electrical power supply system provided by the smart grid system, is considered. The purpose of the article is the formation of clusters of sections of the electrical network, the initial parameters of which are the main indicators of the quality of electrical energy in accordance with the accepted standards. Total harmonic distortion coefficient of voltages, coefficient of unsymmetry of supply voltages, reactive power of loads are chosen as such parameters. The results of the hierarchical clustering of power supply network sections are summarized in the corresponding dendogram. The method of full connection is used to form a dendogram of sections of the power supply system. This method defines the distance between clusters as the largest distance between any objects in different clusters or the most distant neighbors. The measure of closeness was determined by the Euclidean distance. The obtained treeshaped diagram demonstrates the distribution of the sections of the power supply system into four natural clusters, which visually divides the sections of the power supply system into separate groups according to certain characteristics, namely the main parameters of the quality of the power system. It is shown that the mathematical apparatus of cluster analysis allows solving the problem of classification of sections of the power supply system when the main parameters of the quality of electric energy deviate from the normally permissible values. It is proved that the classification can be carried out not only by one parameter, but also by using a combination of several parameters. The results of the conducted analysis provide an opportunity to further form production rules for the selection of measures to improve the quality of electric energy, which are applied to one or another section of the power supply system.)
Effects of Ultrasonic Oscillations on Colloidal Properties of Sulfonated Drilling Fluids
Authors: Peng Bo , Guo Wen-Yu , Li Pan
Published: January 2023

The property development of drilling fluids strongly relies on the emergence of novelty additives and the formulation design of drilling fluids. Few studies focus on the influences of preparation technology on various properties of drilling fluids. At present, high-speed mechanical agitation is still the only method of formulating drilling fluids in the industrial community. In the paper, two kinds of sulfonated drilling fluids that were used frequently in China were prepared by the combination of high-power ultrasound and high-speed mechanical agitation. After the mechanical agitation, we exerted ultrasonic oscillations on the sulfonated drilling fluids and intensified the input of ultrasonic energy by increasing ultrasonic time or power. In addition, the superposition of mechanical agitation during ultrasonic oscillations could further help the sulfonated drilling fluids to absorb more ultrasonic energy when the time and power of ultrasonic oscillations remained unchanged. The effects of ultrasonic oscillations on the colloidal properties of sulfonated drilling fluids were investigated. The results show that the introduction of ultrasonic energy into sulfonated drilling fluids is able to cause the formation of thinner and denser mudcakes on borehole walls and further reduce the low temperature and low pressure (LTLP) and high temperature and high pressure (HTHP) filtrate volume. The HTHP accumulative filtrate volume within 30 minutes can be decreased by a maximum of 24.7%. Simultaneously, various Bingham-type rheological values, particularly yield point, get decreased. The ultrasonic improvement of filtration and rheological properties benefits from the formation of the stable colloidal structure of drilling fluids under acoustic cavitation. According to the total organic carbon (TOC) measurements, it is found that ultrasonic oscillations promote the adsorption of sulfonated additives on bentonite clays. The analysis of particle size and zeta potential also confirms that ultrasonic oscillations not only decrease the average clay particle size but also enhance the zeta potential absolute value. In our experimental range, all the colloidal properties acquire the continuing improvement with the increase in ultrasonic energy input, which cannot be achieved only through the high-speed mechanical agitation. Compared with our previous research works, the subject investigated in the paper is the given drilling fluid system, but not the bentonite suspension containing one single additive. It indicates that we take a step forward in the field application of ultrasound-assisted mud preparation technique.
Nonlinear dynamics of the dual-loop optoelectronic oscillator based on polarization multiplexing.
Authors: Zhang Xiaohao , Wu Ruihuan , Li Bo , Hong Weiyi
Published: January 2023

We theoretically investigate the temporal dynamics of the dual-loop OEO based on polarisation multiplexing. The delay-differential equation (DDE) for this dual-loop OEO system is presented. The microwave envelope equation and its stationary solutions are derived. Then, the stability analysis on the stationary solutions is performed and the gain threshold under the different coupling coefficients when the bifurcation occurs is calculated. In addition, the variation of the output microwave amplitude as a function of the loop gain and coupling coefficient is studied. The experimental measurements confirmed the results obtained from the theoretical and numerical analysis.
Vulnerability reduction in post-conflict areas through a Nexus approach to sustainable food production systems: a case study in Colombia
Authors: Caucci Serena , Guzman-Molina Jairo , Al-Qubati Abdulhakeem , Schellens Marie
Published: January 2023

To increase the resilience of agroecosystems, and allow for sustainable economic reactivation, it is vital that the introduction of sustainable measures - particularly in agriculture – is advanced via an integrated management approach such as the Resource Nexus. An essential aspect of this approach is to optimise the efficiency of ecosystems and resources in conjunction with environmentally friendly economic growth. Colombia has experienced the impact of armed conflict over many years, while geographic regions have been shaped by environmental conflicts; resulting in vulnerable areas suffering from land and population inequalities that also translate into wicked planning for resilient food systems. This paper addresses a double challenge: the improvement of natural resources management and reducing the population's vulnerability in line with the principles of inclusion and gender equity. The paper developed a methodology to identify those productive regions that require improved management at the landscape level, which could benefit under the main framework of the water-energy-food Nexus. It also provides evidence of the value of the science-policy interface to ensure increased social equity, economic growth, and the conservation of resources. A geographic information system approach has been utilised to spatially evaluate the effects of land-use change, ecosystem services provision, and the impacts of climate change at the municipality scale of productive agricultural regions. The objectives of this research were to: (i) evaluate the impact of climate change and anthropogenic activities on natural resources, (ii) assess productive landscape fragmentation due to the overuse of resources, and (iii) consider ecosystem services planning as an operational methodology for municipality ecosystem-based management. The study results show a decrease in the natural Andean Forest, coupled with an increase in agricultural fields over the past 35 years, and a decrease in freshwater availability in the last decade. The expansion trend of the agricultural frontier into the protected areas is also highlighted.
Avalanche Susceptibility mapping of District Shigar, Pakistan using GIS-based MCDA–AHP modeling
Authors: Ali Farman , Zhang Jia-Hua , Alam Masroor , Sajjad Meer , Abbas Saqlain , Hussain Arif , Ramzan Muhammad , Hussain Faisal
Published: January 2023

In snow-covered mountainous terrain like the Himalayas, avalanches are responsible for the majority of fatalities and property damage. Statistics and information on its possibility are typically poor and unavailable in complex terrains. Recognizing avalanche-prone locations and making avalanche susceptibility maps available can assist decision-makers and planners in developing successful avalanche risk reduction strategies. The goal of this research is to use a multi-criteria decision analysis–analytical hierarchy process model in a GIS to create an avalanche susceptibility map for the Shigar valley region, North Pakistan. Slope, aspect, curvature, elevation, terrain roughness, and ground cover are the most important avalanche occurrence components in this model. The analyzed factors were created using STRM DEM and Landsat 8 satellite data. The correctness of the findings is determined by looking at the avalanche inventory map of recorded avalanche sites. The area under the ROC curve (ROC-AUC) method was used to calculate the prediction accuracy. Using ROC-AUC, the validation findings have a prediction accuracy of 91%. Decision-makers on a local and regional level can apply the present study approach in the future to improve avalanche preparedness and planning.
Structure, magnetic, and photocatalysis of La0.7Sr0.3MO3 (M = Mn, Co, and Fe) nanoparticle perovskite: Novel photocatalytic materials
Authors: Ghozzaa Mohamed H. , Yahia Ibrahim S. , Hussien Mai S.A.
Published: January 2023

The present study, La0.7Sr0.3MO3 (M = Mn-, Co-, and Fe-) perovskite, has successfully been synthesized via two techniques; co-precipitation, and sol-gel auto-combustion. XRD, SEM, and EDX characterized the prepared samples. XRD and SEM showed that the as-prepared La0.7Sr0.3MnO3 and La0.7Sr0.3CoO3 have multiphase. La0.7Sr0.3FeO3, in comparison, is nanosized, has a single-phase perovskite, and has a rather homogenous particle size distribution. Additionally, EDX mapping analysis shows that all pieces are distributed uniformly. All calcined powders contain 100% LSF, more than 15% perovskite phase of LSC, 47% LSM, and other secondary phases such cobalt oxide, according to X-ray diffractometer results. At room temperature and magnetic field ± 20 kG. La0.7Sr0.3MnO3 exhibited weak ferromagnetic behaviour in a low magnetic field, whereas diamagnetic behaviour was seen in a high magnetic field. La0.7Sr0.3FeO3 samples behave as strong ferromagnetic. On the contrary, the photodegradation of La0.7Sr0.3MnO3 is 99% compared to 75% and 91% for other samples under UVA lights. The degradation rate for La0.7Sr0.3MnO3 is 0.179 higher, about 3.25 and 2.23, than the other samples. A La0.7Sr0.3MnO3 nanocomposite perform as a photocatalyst to enhance the efficiency of Methylene blue photodegradation.. This study boosts good UVA- photocatalysts with high efficiency for different kinds of dyes. Hence the catalyst possessed high stability and effieiency for continuous treatment of wastewater.
The relationship between prognosis of patients with traumatic brain injury and microRNA biogenesis proteins
Authors: ACAR Ayse CABUKUSTA , YOLDAS Sukran Burcak , GENCER Elif SARIONDER , AYCAN Ilker Onguc , SANLI Suat Hayri
Published: January 2023

Purpose
This study aims to investigate whether the expression levels of proteins involved in microRNA (miRNA) biogenesis vary in the early- and late-stage traumatic brain injury (TBI) patients and to evaluate its effect on prognosis.
Methods
Dicer, Drosha, DiGeorge Syndrome Critical Region 8 (DGCR8), Exportin5 (XPO5), and Argonaute2 (AGO2) levels were measured in the blood samples of moderate TBI patients collected 4 to 6 hours and 72 hours after the trauma and compared with the control group. Prognostic follow-up of the patients was performed using the Glasgow Coma Scale.
Results
There were no statistically significant changes in the expression of the miRNA biogenesis proteins Dicer, Drosha, DGCR8, XPO5, and AGO2 in patients with moderate TBI. However, the expression of Dicer increased in the patients of whose GKS scores and neurologic examination were improved, and the expression of AGO2 decreased in most of these patients. The Dicer expression profile was found to increase in patients discharged from the intensive care unit in a short time.
Conclusions
MicroRNAs and their biogenesis proteins may guide prognostic and therapeutic decisions for patients with TBI in the future.
Long-term Structural and Functional Outcomes after Autologous Retinal Transplant Surgery for Complex Macular Hole
Authors: Rojas Sergio , Medina-Medina Silvia , Torres-Navarro Karla
Published: January 2023

BACKGROUND
Vitrectomy and internal limiting membrane peeling has been the Gold Standard for macular hole treatment since the 90s with high closure rates for idiopathic macular holes, however those larger than 400 um or from other etiologies didn’t have such good outcomes. Over the years, different techniques were developed to increase anatomical and functional success rates, most of them using scaffold tissues; autologous retinal graft showed promising results in these cases, achieving higher closure rates and visual acuity improvement.
SUBJECTS AND METHODS
Observational prospective case series. 6 eyes treated with autologous retinal graft for complex macular holes were included. Baseline best corrected visual acuity (BCVA) and ocular coherence tomography (OCT) were collected. After 12 months of surgery, in all cases a complete ophthalmological examination, OCT, microperimetry, color vision and contrast sensitivity tests were performed at last follow-up.
RESULTS
6 eyes were included with a minimal diameter of 781.7 ± 157.4 um. Initial BCVA was 0.8 ± 0.1 logMAR; all eyes showed improvement or stability: 0.7 ± 0.2 (p: 0.455) at 12-months, that remained stable in most cases at the end of follow-up (p: 0.30), reaching an 83% anatomical and 67% functional success rates. Color vision tests were normal in most of the eyes with a mild tritanopia in one case, regarding contrast sensitivity 5 eyes showed improvement. Microperimetry show some generalized sensitivity loss and residual microescotomas, and fixation stability was variable.
CONCLUSIONS
Autologous retinal graft is an efficient technique for complex macular hole repair with good functional and anatomical outcomes.
Quantifying oil and natural gas system emissions using one million aerial site measurements
Authors: Sherwin Evan , Rutherford Jeffrey , Zhang Zhan , Chen Yuanlei , Wetherley Erin , Yakovlev Petr , Berman Elena , Jones Brian , Thorpe Andrew , Ayasse Alana , Duren Riley , Brandt Adam , Cusworth Daniel
Published: January 2023

Aerial methane surveys of oil and natural gas systems have discovered large emissions, which are missing or vastly undercounted in official estimates. We integrate approximately one million aerial site measurements into regional emissions inventories, employing empirically-grounded emissions simulations to estimate small emissions. We infer emissions inventories for six regions in the United States comprising 52% of onshore oil and 29% of gas production over fifteen aerial campaigns. Total estimated emissions range from 9.63% [9.03%, 10.37%] of natural gas production, roughly nine times the US government estimate, to 0.75% [0.65%, 0.85%] in a high-productivity gas-rich region. Aerially measured emissions at 0.05%-1.44% of well sites contribute 50%-81% of total emissions in twelve of fifteen campaigns. The social cost of methane emissions from these measured regions is roughly $9.4 billion per year, in addition to roughly $1 billion in lost sales. This highlights the importance of incorporating comprehensive remote sensing surveys into emissions inventories and efforts to benchmark and reduce methane emissions.
Effectiveness and safety of P2Y12 inhibitor pretreatment for primary PCI in STEMI: Systematic review and meta-analysis
Authors: Presume João , Gomes Daniel , Ferreira Jorge , Albuquerque Francisco , Almeida Manuel Sousa , Uva Miguel Sousa , Aguiar Carlos , Mendes Miguel
Published: January 2023

Introduction: Dual antiplatelet therapy (DAPT) with both aspirin and P2Y12 inhibitors in patients with ST-segment elevation myocardial infarction (STEMI) has been shown to be associated with better outcomes. Yet, there is uncertainty regarding the optimal timing for its initiation. We performed a systematic review and meta-analysis of evidence on pretreatment with P2Y12 inhibitors in combination with aspirin in patients with STEMI undergoing primary percutaneous coronary intervention (PCI).
Methods and results: We performed a systematic search of electronic databases Pubmed, CENTRAL, and Scopus until April 2022. Studies were eligible if they compared P2Y12 inhibitor upstream administration to downstream use in patients with STEMI submitted to PCI. Studies with patients receiving fibrinolysis or medical therapy only were excluded. Outcomes were assessed at the shortest follow-up available.
Out of 2491 articles, 3 RCT and 16 non-RCT studies were included, with a total of 79300 patients (66.1% pretreated, 66.0% treated with Clopidogrel). Pretreatment was associated with reduction in definite stent thrombosis (OR 0.59 [0.37-0.94]), all-cause death (OR 0.77 [0.60-0.97]), and cardiogenic shock (OR 0.60 [0.48-0.75]). It was also associated with a lower incidence of TIMI flow <3 pre-PCI (OR 0.78 [0.67-0.92]). However, incidence of recurrent MI was not significantly reduced (OR 0.93 [0.57-1.52]). Regarding safety, pretreatment was not associated with a higher risk of major bleeding events (OR 0.83 [0.75-0.92]).
Conclusion: Pretreatment with DAPT, including a P2Y12 inhibitor, was associated with better pre-PCI coronary perfusion, lower incidence of definite stent thrombosis, cardiogenic shock, and, possibly, all-cause mortality with no sign of potential harm encountered.
Coordinated change of PM2.5 and multiple landscapes based on spatial coupling model: a comparison between inland and waterfront cities
Authors: Shen Zhen , Zhang Zhonghao , Cui Lihan , Xia Zheyi , Zhang Yusi
Published: January 2023

Context Landscape heterogeneity is closely related to the spatial differentiation characteristics of PM2.5concentration in urbanized areas. Exploring the changing coordination of landscape evolution and PM2.5change provides robust support for mitigating urban pollution. Previous studies mainly focused on a single landscape in a specific area, lacking a quantitative comparison of multiple landscape evolution and PM2.5concentration changes in different types of cities. Objectives This study aims to quantify how multiple landscapes evolution could affect PM2.5and compare whether and what kind of differences exist among such effects across various regions. Methods Taking two typical inland and waterfront cities in China as examples, this study uses exploratory spatial data analysis and spatial coupling models to compare and analyze the distribution of PM2.5and its coordinated changes with the multiple landscapes (i.e., green, blue, and gray), with townships as the basic unit. Results The PM2.5concentrations in Hohhot and Tianjin have evident differences in spatial concentration. Moreover, the coordinated changes of green landscape and PM2.5in the two regions show opposite trends owing to the effect of the natural background. The change of green landscape to other landscapes in Hohhot can increase PM2.5concentration, with a maximum increase of 2.04 µg/m3. However, this landscape evolution in Tianjin may inhibit PM2.5, particularly in the blue dominant, strong coupling area. Conclusions By comparing the changes in PM2.5concentration caused by multiple landscape evolutions, managers can take differentiated measures tailored to local conditions to provide information for urban planning strategies related to mitigating air pollution.
Propofol pretreatment attenuates glutamate induced excitotoxicity of astrocytes via the p90RSK / Bcl-2 signaling pathway
Authors: Deng Jicai , Chen Xiaoyi , Guan Ruicong , Chen Jing , Li Chunlai , Li Li , Xiao Fei , Xie Yubo
Published: January 2023

Propofol is a short acting anesthetic which can be used in neurosurgery and interventional surgery requiring anesthesia or sedation. Previous studies have suggested that glutamate has a toxic effect on astrocytes, while propofol has a protective effect on brain function. However, their mechanisms have not yet been elucidated. To determine the protective effect of propofol on brain function, we isolated primary astrocytes from the cerebral cortex of 1-day-old rats. After 10 days of culture, primary astrocytes were divided into control group (group C), propofol group (group P), glutamate group (group G), propofol + glutamate group (group PG), propofol + glutamate + inhibitor group (group PGI), and inhibitor group (group I). We then used the CCK8 assay method to test the effect of glutamate and propofol on astrocyte activity, and Western blot analysis to determine the expression of Caspase-3, Bcl-2, Bax, and p90RSK proteins. Moreover, flow cytometry was used to detect the level of apoptosis. Results showed that the expression of p90RSK and Bcl-2 was up-regulated in group P, while the expression of p90RSK and Bcl-2 was down-regulated and the expression of Bax and cleave-caspase3 were increased in group G. The expression of p90RSK and Bcl-2 were increased, while the expression of cleave-caspase3 was decreased in the PG group compared to the G group. In addition, the expression of p90RSK and Bcl-2 was decreased after PD98059 pretreatment. These results suggest that glutamate has a toxic effect on astrocytes, and propofol may attenuate the neurotoxicity of glutamate by activating the p90RSK / Bcl-2 signaling pathway.
EMONO National study in pediatric dentistry: effects sought and experienced
Authors: PRUD'HOMME Tony , Rousselet Morgane , Istvan Marion , Cheraud-Carpentier Marjorie , Dajean-Trutaud Sylvie , Lopez Serena , Muller-Bolla Michèle , Marty Mathieu , (FPDN) Membership of the French Pediatric Dentistry Network , Feuillet Fanny , Victorri-Vigneau Caroline
Published: January 2023

EMONO is an equimolar mixture of oxygen and nitrous oxide and is considered a reference for dental care in children. Completion of dental treatment has usually been used as a criterion to assess EMONO treatment. However, patient-reported outcomes are needed because i) we treat vulnerable subjects, and ii) effects felt can impact dental care prognosis. The aim of this study was to describe the patients’ feelings during EMONO sedation for dental care, especially anxiolytic and analgesic effects. We conducted a national prospective observational multicentric study between September 2018 and June 2020 in 13 French university hospitals. Participants were children between 3 and 15 years of age requiring dental care under EMONO. We assessed i) the prevalence of complete achievement of therapeutic effects (analgesia and anxiolysis) and ii) associated factors using a mixed effects logistic regression. In total, 677 children were analyzed. Anxiolysis and analgesia were experienced by a large majority of patients (86.5% and 79.0%, respectively, and 73% for both effects experienced). Several factors were associated with complete achievement of therapeutic effects: the presence of expected effects (no loss of judgment and slight decrease in level of consciousness), the absence of agitation and distress, a positive perception of EMONO using the VAS and race. Our study characterized the patients who best benefit from the therapeutic effects (anxiolysis and analgesia) expected by EMONO during dental treatment. It is reassuring to observe that most sociodemographic characteristics and medical history do not seem to influence the effectiveness of care.
HPLC fingerprint of thirty seven hop granulates with antioxidant activity tests and chemometric calculations
Authors: Hawrył Anna , Hawrył Mirosław
Published: January 2023

Chemometric techniques (principal component analysis, PCA, hierarchical cluster analysis, HCA, partial least squares, PLS) were applied to compare and predict the antioxidant activity of hops based on chromatographic fingerprints. Besides, isoxanthohumol (IXH) was quantified in order to compare its content in hop extracts. Reversed phase-high performance liquid chromatography with diode array detection (RP-HPLC-DAD) was used to obtain chromatographic fingerprints. Isoxanthohumol was used as fingerprint marker and validation (linearity, accuracy, precision, robustness, limit of detection (LOD), limit of quantification (LOQ)) of HPLC was performed. The chemical similarity between samples was evaluated using PCA and HCA. The total phenolics was determined by Folin-Ciocalteu (F-C) test and the antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). The highest antioxidant activity (DPPH and FRAP) was observed for Cascade, the highest phenolic content was for Callista and Halertauer Tradition. The high antioxidant activity by FRAP test was obtained for Cascade and Magnum. The fingerprints combined with the antioxidant activity were evaluated using the PLS.
EmoAtlas: An emotional profiling tool merging psychological lexicons, artificial intelligence and network science
Authors: Semeraro Alfonso , Vilella Salvatore , Mohammad Saif , Ruffo Giancarlo , Stella Massimo
Published: January 2023

This work introduces EmoAtlas as a computational framework extracting emotions and syntactic/semantic word associations automatically from texts. EmoAtlas implements a cutting-edge synergy of interpretable artificial intelligence (AI) and psychologically-validated lexicons. Our framework supports out-of-the-box emotion detection of 8 categorical emotions and syntactic network building in 18 languages. In the task of detecting emotions in human-labelled social media posts and news media articles, either in Italian or in English, EmoAtlas achieves performances analogous, or even superior (e.g., 70.2% precision for detecting joy in tweets), to state-of-art natural language processing techniques like BERT, RoBERTa, distillBERT and ALBERT (e.g., 67.9% precision for detecting joy in tweets). This performance comes with EmoAtlas being 12 times faster than BERT. In a psychometric task like reproducing human creativity ratings for 1,071 short stories, EmoAtlas and BERT obtain equivalent predictive power (ρ ≈0.495, p<10-4). Combining BERT's semantic features with EmoAtlas' emotional/syntactic networks of words, the cross-validated resulting AIs get substantially better at estimating creativity rates of stories (ρ ≈0.628, p<10-4). This indicates an interplay between the creativity of narratives and the semantic, emotional, and syntactic divergence of their words, pointing out how EmoAtlas and BERT-like models could be used in synergy in psychometrics. By outputting interpretable emotional profiles and syntactic networks, EmoAtlas can quantify how emotions are channelled through specific associations in texts, e.g., how did customers frame their ideas and emotions towards "beds" in hotel reviews? We release EmoAtlas as a standalone computational tool and discuss its impact in modelling texts as data, promisingly filling current research gaps in AI and cognitive science.
A capillary hemangioma of rib with malignant manifestations: a case report and literature review
Authors: Kong Weicheng , Li Wenshan , Chen Wenjuan , Zhou Ludi , Chai Ying
Published: January 2023

traosseous hemangiomas are uncommon intrabony lesions, generally they present in the vertebral skeleton and the calvarium and facial bones with benign manifestations and can be divided into 4 types. However, capillary hemangioma of rib is rare and first reported on 2010, and there was no reported again. Herein we present a 67-year-old man with a capillary hemangioma of the ribs with malignant manifestations. He was diagnosed with lung adenocarcinoma in the left lower lobe and performed lobectomy through uniportal video-assisted thoracic surgery (VATS) on August 16, 2013. In the follow-up, the patient got the left chest pain and the imaging suggested a rib lesion with bone destruction on August 13, 2021, followed by successful costectomy on August 31, 2021, and the pathology finally confirmed as a capillary hemangioma of rib. On follow-up, the patient showing no evidence of recurrence. Findings in this patient may broaden the understanding of intraosseous hemangiomas of ribs.
Analyzing learner language: the case of the Hebrew essay corpus
Authors: Gafni Chen , Sheinfux Livnat Herzig , Klunover Hadar , Prior Anat , Wintner Shuly
Published: January 2023

We present the Hebrew Essay Corpus: an annotated corpus of Hebrew language argumentative essays authored by prospective higher-education students. The corpus includes both essays by native speakers, written as part of the psychometric exam that is used to assess their future success in academic studies; and essays authored by non-native speakers, with three different native languages, that were written as part of a language aptitude test. The corpus is uniformly encoded and stored. The non-native essays were annotated with target hypotheses whose main goal is to make the texts amenable to automatic processing (morphological and syntactic analysis). The corpus is available for research purposes upon request. We describe the corpus and the error correction and annotation schemes used in its analysis. In addition to introducing this new resource, we discuss the challenges of identifying and analyzing non-native language use in general, and propose various ways for dealing with these challenges.
Metamaterial absorber for L-band, S-band and C-band applications
Authors: Shahid Md , Shanmuganantham T. , Kumar S. Ashok
Published: January 2023

In this paper, a unique metamaterial absorber is presented for L-band, S-band and C-band applications. The unit cell of the MMA is designed by a modified square-shape closed-loop resonator printed on top of a dielectric substrate and backed by a copper layer. The proposed structure is ultrathin having total thickness of the absorber is 2.836 mm. The used substrate is FR4 epoxy dielectric substrate (εr = 4.4, tanδ = 0.02) having thickness of 2.8 mm. The absorption performance of the absorber is investigated using Ansys hfss. The absorptions occur in L, S and C bands at 1.21, 3.64 and 5.30 GHz, respectively. Moreover, the average absorption remains above 90%. The MMA structure is unique and insensitive to the angle of incidence across a wide range due to its symmetric structure. It is suitable for various applications like aircraft surveillance, satellite navigation, and non-military radiolocation radars.
Greater soil contribution to vegetation growth in dry regions than in humid regions
Authors: ZHU XINRONG , Luo Xiangzhong , Liu Hongyan
Published: January 2023

The response of vegetation growth to soil moisture is mediated by soil properties, but how and to what extent soil properties affect the response have remained unclear. In this study, we first quantify the global patterns of soil contribution to vegetation growth by establishing a nonlinear vegetation-soil moisture response model. We find that soil properties primarily regulate the nonlinear vegetation-soil moisture response by adjusting the soil moisture optima (SMpoint), which was defined as the peak in a fitted unimodal model. The impacts of soil properties on SMpoint range from − 0.18 cm3/cm3 to 0.16 cm3/cm3. Significant soil impacts on vegetation growth can be positive or negative, depending on soil impacts on SMpoint. In dry regions (Aridity index < 0.65), by adjusting soil water use, soil properties explained 62% of the vegetation growth change on average, and the average change in vegetation growth driven by soil property impacts was only 21% of that in humid ecosystems. Linking soil properties to vegetation responses to soil moisture is important to improve our understanding of droughts and their soil determinants. The results of our study provide insights into the role of soil properties in influencing global vegetation soil water uses and a new framework to consider the impacts of soil properties in global vegetation models.
Survival outcome of different treatment sequences in patients with locally advanced and metastatic pancreatic cancer
Authors: fan mengjiao , deng guochao , si haiyan , wang zhikuan , dai guanghai
Published: January 2023

Background: Chemotherapy remained the basic treatment for patients with advanced pancreatic cancer. We aimed to evaluate the impact of different treatment sequences on clinical outcomes of advanced pancreatic cancer at our academic institution.
Methods: In this single institution retrospective analysis, we assessed characteristics and survival rates from all patients with locally advanced and metastatic pancreatic ductal adenocarcinoma who started a systemic treatment between 01/2015 and 12/2021. Survival analyses were performed by Kaplan-Meier and Cox proportional hazards model.
Results: A total number of 285 patients started a systemic treatment in the observation period, and all patients received at least two lines of treatment. The completion rate of third-line chemotherapy was higher in patients who received FOLFIRINOX or mFLORIFINOX in third-line compared with the patients who received FOLFIRINOX regimen in the first or second-line (chi-square, p=0.04). Furthermore, survival rates of three lines (gemcitabine plus nab-paclitaxel or nab-paclitaxel combination therapy to FOLFIRINOX including plus Bevacizumab; nab-paclitaxel combination therapy to gemcitabine combination therapy, or cross, to oxaliplatin or irinotecan combination therapy; and nab-paclitaxel combination therapy to gemcitabine combination therapy, or cross, to FOLFIRINOX including plus Bevacizumab) were significantly different and median overall survival was 14.00, 14.00, and 18.00 months, respectively (p＜0.05).
Conclusion: Our study provides real-world evidence for the effectiveness of different treatment sequences and recommends nab-paclitaxel combination therapy to gemcitabine combination therapy, or cross, to FOLFIRINOX+/-Bevacizumab to achieve a best overall survival when considering the entire management in advanced pancreatic cancer.
Simultaneously evaluation of physiological and biochemical responses in the leaves and roots of Iranian common bermudagrass [Cynodon dactylon L. (Pers.)] accessions under a wide range of temperature fluctuations
Authors: Amini Zohreh , Salehi Hassan , Chehrazi Mehrangiz , Etemadi Mohammad
Published: January 2023

The average temperature of the earth's surface is increasing rapidly, negatively affecting the urban space's green cover. In this study, to identify Iranian common bermudagrass accessions which could endure a wide range of temperature fluctuations, and be identified as cold-heat tolerant accessions, seven cold-tolerant Iranian accessions including Taft, Naein, Malayer, Gardane-Heyran, Aligoudarz, Safashahr, and Gorgan along with Ahvaz accession as a native accession to tropical regions of Iran were subjected to five high-temperature regimes, including 35/30°C (control), 40/35°C (moderate heat stress), 45/40°C (severe heat stress), 50/45°C (extreme heat stress), and 50/50°C (high-extreme heat stress) day/night cycles for 21 days. At the end of this experiment, it was found that Gorgan and Safashahr accessions were able to endure the 50/45°C TR with acceptable turfgrass quality (heat-tolerant accessions). Ahvaz and Aligudarz accessions could withstand extreme heat stress, but their visual quality was weaker than the former group (semi-heat-tolerant). In contrast, Taft, Naein, Malayer and Gardane-Heyran accessions could not tolerate this harsh condition and their shoots were destroyed (sensitive accessions). Evaluation of physiological parameters (Tchl, RWC, EC and RV), osmolytes (proline, TSC and starch) and antioxidants (SOD, APX, CAT and POX) in leaves and roots after moderate heat stress showed that all parameters except RWC and root viability increased in all accessions. With rising temperature in the 45/40°C TR, root viability in sensitive, semi-tolerant and tolerant accessions increased by 170%, 99% and 143% respectively, and its rate in sensitive accessions was almost twice that of tolerant accessions, while there was no significant difference in the amount of stored starch in their roots. In the continuation of the experiment, when the heat stress became extreme, root viability in sensitive accessions was greatly reduced (89%) and its rate was almost 1/4 of that in tolerant accessions. In such a situation, sensitive accessions could only use 4% of their roots' starch reserves, while semi-tolerant and tolerant accessions used 35% and 47%, respectively. These findings provided that heat-tolerant plants with controlling respiratory rate in roots and efficiently breaking down starch storage to carbohydrates could provide the energy required for whole plant metabolic activities. This experiment also highlights the importance of simultaneously investigating evaluated parameters in leaves and roots.
Use Topic Modeling to Understand Comments in Student Evaluations of Teaching
Authors: Sun Jie , Yan Lu
Published: January 2023

Written comments in student evaluation of teaching offer a rich source of data for understanding instructors’ teaching and students’ learning experiences. However, most of previous researches on student evaluation of teaching have focused on the numeric ratings to close-ended questions, few researches tried to analyze the content of students’ written comments to open-ended questions, which normally involved a labor-intensive manual process of coding and categorizing. Such qualitative efforts prevent solutions on a large scale since it is almost impossible to go through all the textual data manually. Therefore, an innovative quantitative method that can analyze large corpus of data holds great promise. This paper proposed LDA method of topic modeling to discover important themes emerged in students’ written comments. We compared our results with findings in previous qualitative studies. We also investigated how these themes varied by course grade levels and course subjects. Our results provided first evidence that topic modeling can be an effective and efficient alternative to understand teaching and learning experiences through students’ written comments on a large scale.
An Attention-BiLSTM Model for Satellite Operation Prediction with Correlation Telemetry
Authors: Peng Yi , Jia Shuze , Xie Lizi , Shang Jian
Published: January 2023

At present, satellite anomaly is mostly solved after the event, and rarely predicted in advance in satellite health management. Thus, satellite trend prediction is quietly important for avoiding the fault which perhaps affects data accuracy and service quality of satellite, and even impacts greatly on satellite safety. However, it is difficult to predict satellite operation through a simple model because satellite system is complex, and telemetry data is numerous, coupled and spatiotemporal. Therefore, this paper proposes a model combing attention mechanism and Bidirectional Long Short-term Memory (Attention-BiLSTM) with correlation telemetry to predict the situation of satellite operation. Firstly, high-dimensional K-NearestNeighbor Mutual Information (HKNN-MI) method is performed to select the related telemetry variables from multiple variables of satellite telemetry data. Secondly, we put forward to a new BiLSTM model with attention mechanism for telemetry prediction. The dataset for the research is generated and transmitted from the power system of FY3E meteorological satellite. In order to verify the superiority of the proposed model, it is compared with other method based on the same dataset in the experiment. The result shows that the method outperforms other methods due to its better accuracy and prediction precision.
Selective Serotonin Reuptake Inhibitors for the Treatment of Depression in Parkinson's Disease: A Systematic Review and Meta-Analysis Running head: Meta-Analysis of Parkinson's Disease
Authors: Gao Renjie , Zhao Panpan , Yan Kai
Published: January 2023

The authors have requested that this preprint be removed from Research Square.
A case report of central adrenal insufficiency: hiding in persistent, refractory nausea and vomiting
Authors: Yang Jia , Wang Xiao , Tang Jin , Hu Ziling , Xu Tingting , Wang Hongwei , Wang Lei , Cheng Yanmei
Published: January 2023

Background
Central adrenal insufficiency (CAI) is defined as the inability of the adrenal glands to release sufficient corticosteroids due to a series of diseases or injuries of the hypothalamus or pituitary. Signs and symptoms of CAI are insidious, ambiguous, and debilitating. Preceding studies suggest that elderly patients with CAI may present with hyponatremia as a characteristic manifestation, but little is mentioned about gastrointestinal (GI) symptoms. Herein we report a rare case of an elderly male patient with a radio-chemotherapy history for nasopharyngeal carcinoma, in whom prolonged exogenous glucocorticoid replacement and infectious stress from two bouts of bacterial pneumonia combined to cause severe CAI with prodromal symptoms of persistent, intractable nausea and vomiting.
Case presentation
A 71-year-old man presented to the gastroenterology department with persistent nausea and vomiting. Gastroscopy, brain magnetic resonance imaging (MRI), and contrast-enhanced abdominal computed tomography (CT) were performed to exclude organic lesions. The diagnosis of CAI was confirmed by checking the levels of basal cortisol and adrenocorticotropic hormone. After replacement therapy with hydrocortisone, the patient's GI symptoms resolved rapidly, hyponatremia was corrected. At subsequent follow-ups, he was doing well with no hospitalizations.
Conclusion
CAI in elderly patients can start with persistent, refractory nausea and vomiting, and is featured by uncorrectable and insidious hyponatremia. Timely hydrocortisone replacement therapy averts life-threatening adrenal crises.
Study on Sequence Mutation and Molecular Dynamics Simulation of D614G SARS-CoV-2 Spike Protein in Indonesia
Authors: Rahmi Aulia Fauziyyah , Utomo Didik Huswo , Susanti R.
Published: January 2023

Amino acid mutations in the D614G spike protein of SARS-CoV-2 need to be studied more deeply for their influence on the pathogenesis of the virus. The purpose of this research was to analyze 1) the variation and kinship of the SARS-CoV-2 spike protein gene; 2) the effect of D614G spike protein mutation on ACE2 receptor binding and the molecular dynamics simulation. The nucleotide sequence of SARS-CoV-2 virus isolate was downloaded from GISAID and NCBI. Classification of SARS-CoV-2 clades and construction of the phylogenetic tree using MEGA-program. Molecular dynamics simulation was demonstrated with GROMACS to compare the stability of D614 and G614 S proteins. The result of this research showed that the most common GH clade SARS-CoV-2 virus isolates were be discovered in Indonesia, and the percentage of isolates with the D614G mutation reached 97% in Indonesia. The clade with the D614G mutation made the SARS-CoV-2 virus more varied with new mutations and increased human-to-human transmision. In this study, an increase in infectivity or spread of the SARS-CoV-2 D614G virus most likely resulted from an increase in the strength of the S protein and a slight change in RBD conformation seen from the molecular interactions around the mutation area and the RMSF value (0.3144 nm for D614G, and 0.3818 nm for D614). This is likely to be the cause of the massive spread of variants belonging to VOC and VBM, where all these variants have the D614G mutation.
Pyroptosis-related bioinformatics analysis reveals that IL1A is a prognostic biomarker in oral squamous cell carcinoma
Authors: Chen Gaoxiang , Shao Tingru , Lu Xinyan , Zheng Zenan , Lv Xiaozhi
Published: January 2023

Background: Increasing evidence has demonstrated that pyroptosis plays a crucial role in tumor carcinogenesis and progression. However, there is little information concerning pyroptosis-related genes (PRGs) in oral squamous cell carcinoma (OSCC). Purpose of our study was to explore the prognostic value of PRGs in OSCC patients.
Materials and methods: RNA-seq and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database and PRGs were extracted from the expression profiles. Then, differentially-expressed analysis and functional enrichment analysis were performed. A prognostic model based on PRGs was constructed in R software. Moreover, comprehensive bioinformatics analyses were used to verify the prognostic model and select pyroptosis-related biomarkers.
Results: A total of 35 genes were categorized as differentially-expressed PRGs and Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis showed that these genes were mainly located in inflammasome complex and associated with pyroptosis. CHPM3, GSDMB, IL1A and NLRP1 were used to establish the prognostic model. Risk scores of each patients was calculated by using the risk-score formula and a nomogram was plotted to visually predict the survival of the OSCC patients. Then half-maximal inhibitory concentration (IC50) of 30 common anticancer drugs was analyzed between patients in high-risk and low-risk cohorts. In the end, IL1A was identified as potential pyroptosis-related biomarkers of OSCC.
Conclusion: This study established a novel pyroptosis-related prognostic model, provided a novel strategy for predicting the survival of OSCC patients. Moreover, IL1A was identified as an independent pyroptosi-related biomarker and may be a potential target for OSCC.
Male Infertility in Nigeria and South Africa: A Ten-Year Observational Study
Authors: Akang Edidiong Nnamso , Opuwari Chinyerum Sylvia , Enyioma-Alozie Swesme , Moungala Lionel Wildy , Amatu Tamarapreye Emmanuel , Wada Ibrahim , Ogbeche Rose Ogeyi , Ajayi Oluwatoyin Omolayo , Aderonmu Mojisola Modupe , Shote Olaitan Boluwatife , Akinola Lateef Adekunle , Ashiru Oladapo Adenrele , Henkel Ralf
Published: January 2023

Background: Male infertility is a disease of public health relevance contributing to 50% of infertility cases globally. However, there is dearth of information on the prevalence of male-factor infertility in Sub-Saharan countries. Therefore, in this study we aimed at identifying the prevalence, and trends of male factor infertility in Nigeria and South Africa over a period of ten years between 2010 and 2019.
Methods:A retrospective study of semen analyses of 17,292 men attending fertility hospitals in Nigeria and South Africa in 2010, 2015 and 2019. Patients who had undergone vasectomy and those who had a pH less than 5 or greater than 10 were excluded from this study. The following variables were assessed: ejaculate volume, sperm concentration, progressive motility, total progressively motile sperm count (TPMSC), total sperm count, and normal sperm morphology
Results:
Between 2010 and 2019, significant trends of decreasing values were observed in normal sperm morphology (-50%), progressive motility (-89%), TPMSC (-91%) and the ejaculatory volume (-7%), indicating a progressive deterioration of the values in both countries. In Nigeria, there were significant decreases in progressive motility (-87%), TPMSC (-78%), and sperm morphology (-50%) between 2015-2019 (p<0.0001). Spearman`s rank correlation revealed significant negative associations between age and morphology (ρ = -0.24, p<0.0001), progressive motility (ρ= - 0.31. p<0.0001), and TPMSC (ρ = -0.32, p<0.0001). Patients in South Africa were younger than those from Nigeria, with also a significantly higher sperm morphology, sperm concentration, progressive motility, total sperm count and TPMSC.
Conclusion: Our findings provide a quantitative evidence of an alarming decreasing trend in semen parameters in Nigeria and South Africa from 2010 to 2019. It also proves that astheno- and teratozoospermia are the leading causes of male infertility in these regions. In addition to this, it also shows empirically that semen parameters decrease with advancement in age. These findings are the first report on male-factor infertility prevalence in Sub-Saharan countries, necessitating a thorough investigation on the underlying factors promoting this worrisome decline.