bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of significant biomarkers for predicting the risk of bipolar disorder with arteriosclerosis based on integrative bioinformatics and machine learning
Authors: Zheng Xiabing , Zhang Xiaozhe , Zhang Yaqi , Chen Cai , Ji Erni
Published: September 2024

Introduction

Increasing evidence has indicated a connection between bipolar disorder (BD) and arteriosclerosis (AS), yet the specific molecular mechanisms remain unclear. This study aims to investigate the hub genes and molecular pathways for BD with AS.

Methods

BD-related dataset GSE12649 were downloaded from the Gene Expression Omnibus database and differentially expressed genes (DEGs) and key module genes derived from Limma and weighted gene co-expression network analyses (WGCNA) were identified. AS-related genes were sourced from the DisGeNET database, and the overlapping genes between DEGs and AS-related genes were characterized as differentially expressed arteriosclerosis-related genes (DE-ASRGs). The functional enrichment analysis, protein-protein interaction (PPI) network and three machine learning algorithms were performed to explore the hub genes, which were validated with two external validation sets. Additionally, immune infiltration was performed in BD.

Results

Overall, 67 DE-ASRGs were found to be overlapping between the DEGs and AS-related genes. Functional enrichment analysis highlighted the cancer pathways between BD and AS. We identified seven candidate hub genes (CTSD, IRF3, NPEPPS, ST6GAL1, HIF1A, SOX9 and CX3CR1). Eventually, two hub genes (CX3CR1 and ST6GAL1) were identified as BD and AS co-biomarkers by using machine learning algorithms. Immune infiltration had revealed the disorder of immunocytes.

Discussion

This study identified the hub genes CX3CR1 and ST6GAL1 in BD and AS, providing new insights for further research on the bioinformatic mechanisms of BD with AS and contributing to the diagnosis and prevention of AS in psychiatric clinical practice.
Unilateral vs. bilateral DLPFC rTMS: comparative effects on depression, visual-spatial memory, inhibitory control and cognitive flexibility in major depressive disorder
Authors: Asgharian Asl Fatemeh , Abbaszade Sajjad , Derakhshani Horeyeh , Vaghef Ladan , Asgharian Asl Amirreza
Published: September 2024

Background

Exciting left DLPFC activity with high frequency and inhibiting right DLPFC with low frequency repetitive transcranial magnetic stimulation (rTMS) has shown antidepressant effects in major depressive disorder (MDD) and executive functions. However, few studies have directly compared unilateral and bilateral protocols.

Methods

Forty-seven individuals with treatment-resistant MDD underwent 10 sessions of rTMS over left DLPFC (20 Hz), bilateral DLPFC (left 20 Hz, right 1 Hz), or sham stimulation. Outcomes were depression (Beck Depression Inventory-II), visual-spatial memory (Corsi Block Test), response inhibition (Go/No-Go task), and cognitive flexibility (Wisconsin Card Sorting Test) assessed before and after treatment.

Results

Both unilateral and bilateral rTMS significantly reduced depression levels versus sham controls based on BDI-II scores. While bilateral stimulation did not improve Corsi Test performance, unilateral protocol enhanced visual-spatial memory. On the Go/No-Go task, accuracy was higher in both active stimulation groups compared to sham, with no response time differences. Neither unilateral nor bilateral rTMS had significant effects on cognitive flexibility per the WCST.

Conclusions

Despite comparable antidepressant effects, unilateral stimulation had some cognitive advantages over bilateral rTMS, potentially due to greater left dorsolateral prefrontal cortex excitation. Further research on parameter optimization is warranted.
Soil zinc surveillance frameworks can inform human nutrition studies: opportunities in India
Authors: Khokhar Jaswant S. , Broadley Martin R. , Ander E. Louise
Published: September 2024

Mineral micronutrient deficiencies are widespread in global food systems and can affect plant growth, crop quality, and human and livestock health. The mapping of soils and soil properties linked to micronutrient supply in food systems is now enabling us to better understand the linkages between soil health and function and its relationship with food quality and human health. Zinc (Zn) deficiencies in Indian soils are of particular concern in the context of crop yields and food quality. This current review aims to understand the data landscapes on soil Zn and related soil properties in India, with a particular focus on three states: Uttar Pradesh (UP), Bihar, and Odisha. The scope of the review is to identify and describe data sets from national and state-wide programmes and research experiments in which soil Zn has been reported, which could be used to provide a framework for integrated surveys and would combine wider agriculture, food systems, nutrition, and public health sectors. The largest data set on soil Zn was collected under a soil health management (SHM) programme, during which the Indian government analysed more than 30 million soil samples for Zn concentration (mg/kg) from 2015 to 2019. This study showed that 39% of Indian soils are considered Zn deficient for crop production (i.e., based on a threshold of <0.6 mg/kg); soil Zn deficiency varied from 2% to 67% across different Indian states. From this survey, soil Zn deficiency was 29%, 67%, and 48% in UP, Bihar, and Odisha, respectively. Individual data points are available for re-use at the Government of India soil health card website (https://www.soilhealth.dac.gov.in/). In addition, the All India Coordinated Research Project on Micro and Secondary Nutrients and Pollutant Elements in Soils and Plants (AICRP-MSPE) programme under the Indian Council of Agricultural Research (ICAR) analysed >240,000 soil samples from 2012 to 2018 from 28 states of India and reported ~38% soil Zn deficiency in the Indian soils. There is no programme in India that currently maps micronutrients in soil and crops together using “GeoNutrition” approaches recently reported in two countries in Africa, Ethiopia, and Malawi. Future co-ordinated soil and crop micronutrient mapping in India can help us to understand better the movement of Zn (and other micronutrients) in food systems and to inform strategies to improve the Zn status in the soil, e.g., the use of Zn fertilisers for yield and agronomic biofortification, and in the edible tissues of crops, e.g., through genetic biofortification.
Prediction of ionospheric TEC during the occurrence of earthquakes in Indonesia using ARMA and CoK models
Authors: Kiruthiga S. , Mythili S.
Published: September 2024

Predicting ionospheric Total Electron Content (TEC) variations associated with seismic activity is crucial for mitigating potential disruptions in communication networks, particularly during earthquakes. This research investigates applying two modelling techniques, Autoregressive Moving Average (ARMA) and Cokriging (CoK) based models to forecast ionospheric TEC changes linked to seismic events in Indonesia. The study focuses on two significant earthquakes: the December 2004 Sumatra earthquake and the August 2012 Sulawesi earthquake. GPS TEC data from a BAKO station near Indonesia and solar and geomagnetic data were utilized to assess the causes of TEC variations. The December 2004 Sumatra earthquake, registering a magnitude of 9.1–9.3, exhibited notable TEC variations 5 days before the event. Analysis revealed that the TEC variations were weakly linked to solar and geomagnetic activities. Both ARMA and CoK models were employed to predict TEC variations during the Earthquakes. The ARMA model demonstrated a maximum TEC prediction of 50.92 TECU and a Root Mean Square Error (RMSE) value of 6.15, while the CoK model predicted a maximum TEC of 50.68 TECU with an RMSE value of 6.14. The August 2012 Sulawesi earthquake having a magnitude of 6.6, revealed TEC anomalies 6 days before the event. For both the Sumatra and Sulawesi earthquakes, the GPS TEC variations showed weak associations with solar and geomagnetic activities but stronger correlations with the earthquake-induced electric field for the considered two stations. The ARMA model predicted a maximum TEC of 54.43 TECU with an RMSE of 3.05, while the CoK model predicted a maximum TEC of 52.90 TECU with an RMSE of 7.35. Evaluation metrics including RMSE, Mean Absolute Deviation (MAD), Relative Error, and Normalized RMSE (NRMSE) were employed to assess the accuracy and reliability of the prediction models. The results indicated that while both models captured the general trend in TEC variations, nuances emerged in their responses to seismic events. The ARMA model demonstrated heightened sensitivity to seismic disturbances, particularly evident on the day of the earthquake, whereas the CoK model exhibited more consistent performance across pre- and post-earthquake periods.
Image Registration Algorithm for Stamping Process Monitoring Based on Improved Unsupervised Homography Estimation
Authors: Zhang Yujie , Du Yinuo
Published: September 2024

Homography estimation is a crucial task in aligning template images with target images in stamping monitoring systems. To enhance the robustness and accuracy of homography estimation against random vibrations and lighting variations in stamping environments, this paper proposes an improved unsupervised homography estimation model. The model takes as input the channel-stacked template and target images and outputs the estimated homography matrix. First, a specialized deformable convolution module and Group Normalization (GN) layer are introduced to expand the receptive field and enhance the model’s ability to learn rotational invariance when processing large, high-resolution images. Next, a multi-scale, multi-stage unsupervised homography estimation network structure is constructed to improve the accuracy of homography estimation by refining the estimation through multiple stages, thereby enhancing the model’s resistance to scale variations. Finally, stamping monitoring image data is incorporated into the training through data fusion, with data augmentation techniques applied to randomly introduce various levels of perturbation, brightness, contrast, and filtering to improve the model’s robustness to complex changes in the stamping environment, making it more suitable for monitoring applications in this specific industrial context. Compared to traditional methods, this approach provides better homography matrix estimation when handling images with low texture, significant lighting variations, or large viewpoint changes. Compared to other deep-learning-based homography estimation methods, it reduces estimation errors and performs better on stamping monitoring images, while also offering broader applicability.
Advanced Analysis of Structural Performance in Novel Steel-Plate Concrete Containment Structures
Authors: Ren Guopeng , Pan Rong , Sun Feng , Dong Zhanfa , Lan Tianyun
Published: September 2024

This paper investigates the structural performance of novel steel-plate concrete containment structures, focusing on third-generation nuclear power plants. To address the challenges of increased complexities and costs associated with double-layer containment designs, this study explores the potential of steel-plate concrete structures to enhance safety, economic efficiency, and construction simplicity. The steel-plate concrete structure, characterized by its core concrete and dual steel plates, shows superior compressive strength, bending resistance, and elastoplasticity. Extensive numerical analyses, including finite element modeling and thermal-stress coupling, were conducted under various load conditions. Under structural integrity test conditions, the maximum radial displacement observed was 24.59 mm. Under design basis conditions, the maximum radial displacement was 47.61 mm; under severe accident conditions, it was 53.83 mm. The ultimate bearing capacity was 0.91 MPa, 2.17 times the design pressure. This study concludes that the steel-plate concrete containment structure maintains a high safety margin under all tested conditions, with stress and strain well within acceptable limits. It can effectively serve as a robust barrier against radioactive leakage and malicious impacts, providing a viable alternative to conventional containment designs.
Editorial for the Special Issue on Additive Manufacturing of Advanced Composites
Authors: Chen Yuan
Published: September 2024

Advanced composites are attracting increasing attention in industrial applications due to their excellent performance, i [...]
Analysis of the Use of Energy Storage in the Form of Concrete Slabs as a Method for Sustainable Energy Management in a System with Active Thermal Insulation and Solar Collectors
Authors: Król Barbara
Published: September 2024

One effective approach to reducing the energy required for heating buildings is the use of active thermal insulation (ATI). This method involves delivering low-temperature heat to the exterior walls through a network of pipes carrying water. For ATI to be cost-effective, the energy supply must be affordable and is typically derived from geothermal or solar sources. Solar energy, in particular, requires thermal energy storage (TES) to manage the gap between summer and the heating season. A building that integrates various renewable energy systems and heating/cooling technologies should be managed efficiently and sustainably. The proper integration of these systems with smart management strategies can significantly lower a building’s carbon footprint and operational costs. This study analyzes the use of concrete slabs as a method for sustainable energy management in a system incorporating active thermal insulation and solar collectors. Using ambient temperature and solar radiation data specific to Cracow, Poland, the simulations evaluate the feasibility of employing a concrete slab positioned beneath the building as a thermal storage tank. The results reveal some drawbacks of using concrete slabs, including high temperatures that negatively affect system efficiency. Increased temperatures lead to higher heat losses, and during summer, inadequate insulation can cause additional heat leakage into the building. The findings suggest that water may be a more effective alternative for thermal energy storage.
Regarding the establishment of the anti-burn «Fenix-MS» bed conformity with the requirements of quality and safety standards
Authors: Kuzmenko Oleksandr , Starunskyi Anatolii , Abdulin Salekh , Semenenko Mykhailo
Published: September 2024

The standards that anti-burn beds must meet are given. The design of the domestically produced anti-burn «Phoenix-MS» bed, which has improved design and technological indicators, is briefly described. The main test results of this bed, obtained in the process of independent conformity assessment, are presented. Their analysis showed that the product meets quality standards and ensures the safety of patients and medical personnel during its operation in medical institutions. It is noted that the manufacturer needs to carry out a more complete clinical evaluation of the product, taking into account the strengthening of this requirement in the new EU Regulation 2017/745 on medical devices.
A novel method for measuring electrolytic conductivity with a polarization impedance control function
Authors: Stennik Oleksii , Mikhal Oleksandr
Published: September 2024

The article presents an idealized model of the differential method utilized in conductometry to measure electrolytic conductivity (EC). It identifies the main drawback of the widely used differential method: the inability to control the influence of polarization impedance on EC measurement results. A criterion for the absence of error caused by polarization effects is proposed, involving equality between the ratios of resistance differences and cell constant differences. A novel method for EC measurement, termed the double differential method, is introduced. This method relies on repeated differential impedance measurements and incorporates an additional third impedance measurement of a virtual liquid column. The new approach enables the identification of polarization impedance influence on EC measurements and the calculation of measurement errors for correction. A 3 times lower type A measurement uncertainty value can be achieved by averaging the corrected results.
How The Use Of Social Media As A Public Relations Tactic Has Aided Animal Rescue Organisations In Raising Awareness Of Their Cause
Authors:   ,   Cork Institute of Technology, Hennessy Carole
Published: September 2024

"This study aims to contribute to the understanding of the non-profit sector, in particular animal welfare organisations and how social media can be used as a Public Relations tactic which in turn enables them to raise awareness of their cause. A qualitative research design was deemed the most suitable by the researcher. Semi-structured interviews and a content analysis in the form of a netnographic analysis of the chosen non-profit organisations Facebook pages were used to collect the primary data. Interviewees were chosen on the basis they had knowledge, experience and exposure in their area. Research findings indicate that social media is an important tool in the arsenal of a non-profit organisations Public Relations effort. The researcher discovered it is not necessarily the biggest organisations that use social media the most effectively. The research concludes that while there are some disadvantages regarding non-profit organisations use of social media. These prove insignificant when weighed against the advantages. Social media and in particular a Facebook platform lends itself to non-profits in extending their reach, which enables them to fundraise and therefore continue on with their mission."
Development Of a Recombinant Lactobacillus Salivarius for Prophylactic Applications Against Mycobacterium Avium Subspecies Paratuberculosis and Johne's Disease
Authors:   ,   Cork Institute of Technology, Johnston Christopher
Published: September 2024

Current whole-cell vaccines against Mycobacterium avium subsp. paratuberculosis, the etiological agent of Johne’s disease, are unable to provide complete protection against infection. Moreover, such whole-cell formulations interfere with diagnostic tests for bovine tuberculosis (Mycobacterium bovis). The development of subunit vaccines, those which are preferentially based on one, or a select few, immunodominant protective antigens is considered as the realistic next step in overcoming these issues. The (MAP) K-10 genome is a single circular chromosome of 4,829,781 base pairs and encodes 4,350 predicted ORFs. In order to identify MAP specific proteins for subsequent incorporation within a mucosal based vaccine development, a subtractive sequence-based comparison was conducted using the entire MAP K-10 genome against a number of other completed Mycobacterial genomes. A bank of five candidate antigens including MAP specific, membrane associated and virulence related proteins has been identified. The expression of these antigenic candidates within a Lactobacillus salivarius delivery host will require further investigation.
Do Irish Consumers Understand Financial Risk In Savings And Investment Products In The Irish Financial Services Market?
Authors:   ,   Cork Institute of Technology, Burrows Alan
Published: September 2024

"This thesis focuses on Irish adult consumers and examines whether they understand the financial risk pertaining to the savings and investment products that they purchase in the Irish financial services market. This study is important because there is no up to date data currently available on this topic, specifically and solely related to Ireland and to Irish consumers. The findings of this study are significant because, if consumers lack an understanding of financial risk, it can potentially lead to mistakes in financial decisions which may lead to negative financial repercussions for consumers throughout their life and into retirement. In this study, the researcher applied a mixed methods approach to gathering the empirical evidence. Quantitative research was employed by means of a survey questionnaire issued to Irish consumers, which they completed on-line, on which they answered both theoretical and practical questions relating to their understanding of financial risk. Qualitative research was undertaken through the use of an interview guide with selected senior and professional members of the wider Irish financial services industry. During the interviews, data was obtained relating to the industry's view of Irish consumer financial literacy and their suggestions on how financial literacy may be improved. 84% of financial services industry interviewees believe that Irish consumers do not fully understand financial risk. This finding was corroborated by various results from the consumer survey during the quantitative research. In the consumer survey, a significant finding was that just 7.58% of respondents stated that they complete a risk assessment process prior to saving or investing. This study will be of interest to all parties involved in, and connected with, the Irish financial services industry. This includes the Financial Regulator, the Financial Services Ombudsman, the Pensions Ombudsman, the National Consumer Agency, the Professional Insurance Brokers Association {PIBA), and the Irish Brokers Association (IBA), among others. It will also be of significant interest to all consumers as well as all the life assurance companies, banks, credit unions, stockbrokers, financial advisors, tied agents, direct sales agents, fund managers, product manufacturers, and all financial services operatives in the Irish market. This study will be of benefit to all of the above mentioned parties as remedial action in terms of product manufacture, marketing, literature and sales can be implemented based on the research findings. Consumers will benefit from this study through awareness and ideally through educational improvements, as well as industry improvements. "
Structural Behaviour Of Semi-continuous Steel End Plate Connections
Authors:   ,   Cork Institute of Technology, Scollard Niall
Published: September 2024

"This report focuses on determining the joint stiffness and moment capacity values for semi-continuous (semi-rigid) connections in steel framed structures. When designing a beam to column connection, the assumption that the Joint is either fully continuous or fully pinned may not be entirely valid; it may be more realistic to classify the connection as intermediate between fully pinned and fully continuous. The development of “the component method”, which is utilised in IS EN 1993-1-8 (EC3) to determine design values of the joint properties is described. A software solution was created using Microsoft Excel to carry out calculations in accordance with IS EN 1993-1-8 to determine design values for the joint properties for typical end plate connections. The use of finite element modelling to determine the properties of semi-continuous joints is examined. The development of finite element models using LUSAS software and the attributes required to create the models are described. Structural tests were carried out on a total often different joint configurations in the Heavy Structures Laboratory at Cork Institute of Technology. A comparison between the joint properties obtained using the method described in IS EN 1993-1-8, models developed using LUSAS and the results obtained from the structural testing is provided. The development of a LUSAS model to determine the joint’s behaviour is more feasible than carrying out a structural test in each case. The LUSAS models developed have been shown to be a more accurate representation of the joint’s behaviour than the EC3 model and provide safe stiffness values and moment capacity values in most cases when compared with the test results."
Non-uniform Transmission Lines For Ultra Wideband: Design Optimisation And Interfacing To Antennas And Loads
Authors:   ,   Cork Institute of Technology, Narayanan Prasanth
Published: September 2024

"This thesis presents the electrical characterization of ultra-wideband non- uniform transmission lines (UWB NUTLs). Non-uniform transmission lines have been identified as a successful device for ultra-wideband pulse shaping, which can be designed to generate complex and arbitrary pulse shapes as an impulse response. The performance of a range of UWB NUTLs, with different substrate materials and load impedances, has been characterised. In addition, the possibility of interfacing NUTL with antennas and the filtering effect of antennas has been investigated. To characterise the NUTLs, knowledge of current literature related to NUTL designs is required. A detailed review of the literature published on topics related to microwave methods for electrical characterization of dielectric substrate materials, design of NUTLs for pulse shaping and measurements with UWB antennas has been presented. The literature review details the need for further study to characterise NUTLs and the advantages of NUTLs compared to traditional pulse shaping methods. To design UWB NUTLs on different substrate materials, the broadband dielectric characteristics of the materials need to be known over a bandwidth of about 10GHz. Such information is not readily available from manufacturers. To do this, a novel broadband microstrip line-based permittivity measurement method has been developed. Measurement and simulation of the broadband relative permittivity of four different substrate materials using this method have been carried out. To identify the effect of different substrate materials, NUTLs have been manufactured with four different substrate materials with permittivity values in the range of 2.5 - 10 and their responses have been analysed. The results show that the loss and dispersive effect is significantly visible in an ordinary high loss substrate, FR4. The effect of various resistive, capacitive and inductive load terminations on NUTL’s response has also been studied. The experimental results show that the characteristics of load impedances do not influence the NUTL’s impulse response. In addition, the various load impedances can be identified from the impulse response of the respective loads. Finally, the effect of antennas on NUTL performance has been studied by integrating NUTLs with UWB antenna and measuring the response."
Ultrafast Carrier Dynamics In Semiconductor Nanostructures
Authors:   ,   Cork Institute of Technology, Pulka Jaroslaw
Published: September 2024

Rapid development of telecommunication systems forces a switch to all- optical data processing and transmission. To design such systems it is critical to understand the ultrafast processes which occur in the components of such systems, especially in Monolithic Modelocked Lasers. The purpose of this work was to identify the main physical processes influencing carrier dynamics in semiconductor nanostructures which show promise for future telecommunication systems. This study was carried out by means of ultrafast pump-probe spectroscopy, which allowed characterisation with a sub-picosecond resolution. The main part of the thesis concentrates on the analysis of the InAs/GaAs Quantum Dot (QD) system. The gain regime of optical amplifiers has already been extensively investigated while little knowledge of the behaviour of the optical amplifier in the absorption regime existed. Therefore this work focuses on an extensive study of the dynamical behaviour of optical amplifiers in the absorption regime and was studied by means of two colour pump-probe spectroscopy and accompanying numerical simulations. In addition a Tunnel Injection device operating at 1.3μm was also investigated to examine the possibility of it having improved dynamical properties over simple QD structures operating at the same wavelength. Due to the interest in structures operating at different wavelengths experiments were also performed for dilute nitride QW operating at 1.55μm and for novel AlInAs/AlGaAs QD material system operating at 800nm.
A Decision Making Tool For Sustainable Design In Construction
Authors:   ,   Cork Institute of Technology, Collins Enda
Published: September 2024

"This report defines sustainability and sustainable development before any research is carried out. This is necessary so that the research carried out further in the report makes sense and there is a reason for including such items in this report. The need for this project and what the project aims to achieve is also highlighted in the introduction of this report. Sustainability is made up of three equal parts; social, economic and environmental. This report goes through each item and gives examples of each type of development. Having discussed sustainability in a broad sense the report then focuses on Legislation that has an impact on Ireland in terms of sustainability. The Planning Act, Building Control Act, Building Regulations and the EU 2020 Climate and Energy Package have all direct influences on the developments that are constructed in the is country. When investigating sustainability in Ireland it was important to compare Ireland to what outlier countries in Europe and throughout the world are doing when it comes to sustainability. A number of international sustainability analysis tools have been compared to determine their merits in terms of adopting them into this decision making tool being created or in fact adapting them to suit Ireland. Other international practices that have a use in Ireland have also been reviewed such as Sustainable Urban Drainage and Cost Benefit Analysis. The Greater Dublin Drainage Study investigated the merits and uses of sustainable urban drainage and as a result it has been included in the Building Regulations as a suitable option for drainage issues that arise from a development. Cost Benefit Analysis has been looked at as it is quite similar to a sustainability analysis in that not just financial aspects of a project are looked at and a value put on these items. The net result of all the costs and benefits to a development determines if the project is viable and sustainable. Again this is originally an international practice but today is relevant in terms of an Irish context. Finally the method of creating this tool has been investigated with the focus on Microsoft Excel and the VBA function in Excel. This will be the starting point for the tool as the computer programming code associated for with VBA has been studied and the basics learned so as to get a strong foothold when starting to create the tool. A timeline for works in the implementation phase has also been included which has realistic targets set out as well as a step by step guide as to how the next phase of the project will be completed."
Cooperation of the Lublin Triangle in the context of security threats in the region of Central and Eastern Europe
Authors: BĄK-PITUCHA Aneta , KUCZYŃSKA-ZONIK Aleksandra , SZACHOŃ-PSZENNY Anna , ZARĘBA Agnieszka
Published: September 2024

The purpose of this article is to outline the new multidimensional format of cooperation between Poland, Lithuania, and Ukraine. The Lublin Triangle is a trilateral regional alliance between Poland, Lithuania, and Ukraine established in Lublin on 28 July 2020. The initiative relates to cooperation across the power, infrastructure, security and cultural sectors with an aim to strengthen dialogue between the states and reinforce efforts to restore Ukraine’s territorial integrity and support its integration into the European Union (EU) and the North Atlantic Treaty Organization (NATO). Some of the factors driving this new format of cooperation include the growing migrant crisis; increasing importance of the internal and external security in the EU states; Ukraine’s pursuit of EU integration, especially after the Ukraine war outbreak; and strengthening of national states within the EU. The states concerned have turned back to their legacy capital which is and has been the same regional affiliation and, thus, the geographical proximity, shared past, culture, and common interests.
Catalytic alcoholysis of fiberglass reinforced epoxy resin composites
Authors: Protsenko A. E.
Published: September 2024

The article presents the results of a study of alcoholysis of fiberglass reinforced epoxy resin composites obtained by vacuum infusion. To intensify alcoholysis, chlorides, nitrates and sulfates of cobalt (II) and copper (II) were introduced into the reaction medium in an amount of 5% of the mass of ethyl alcohol for each system. The efficiency of the system was assessed based on data from the analysis of mass change of composite samples during alcoholysis, thermogravimetric analysis and scanning electron microscopy. It was found that the presence of metal chlorides contributes to 5 times increase of the alcoholysis velocity. The residual strength of the recovered fiber samples obtained is at least 95%.
CAMINHOS PARA A INCLUSÃO: DESAFIOS E ESTRATÉGIAS NO ATENDIMENTO A CRIANÇAS COM AUTISMO NA EDUCAÇÃO INFANTIL EM BELÉM/PA
Authors: Maria das neves caldeira Thays , dos Santos Alves Osvando
Published: September 2024

The discussion and reflection presented in this text are the result of a case study conducted at a Municipal Public School for Early Childhood and Elementary Education located in the Municipality of Belém/PA. The aim is to present aspects of how the inclusion of autistic children is being implemented at the Municipal Public School for Early Childhood Education in Belém/PA, and thus contribute to discussions in the field. The investigative approach followed a qualitative method and case study. The results highlight that the lack of support for teachers, both personal and material, and the absence of differentiated strategies to integrate autistic children into the school group have been limiting factors for effective inclusion. It is concluded that the teacher plays a leadership role in creating an inclusive culture and adapting the curriculum so that autistic children have access to the educational process.
Saisir l’interrelation des technologies numériques et de la musique dans l’expérience migratoire : les parcours de personnes immigrantes maghrébines au Québec
Authors: Marcoux-Gendron Caroline
Published: September 2024

Cet article traite de l’interrelation des technologies numériques et de la musique dans la vie de personnes immigrantes. Il s’inscrit de la sorte dans le prolongement des travaux qui discutent du changement de paradigme occasionné par le numérique en matière de migrations humaines comme d’écoute de musique, offrant par ailleurs une combinaison originale des trois notions. La réflexion s’appuie sur une enquête auprès de personnes nées au Maghreb (Algérie, Maroc et Tunisie) et vivant à Montréal (Québec, Canada), dont les écoutes et pratiques liées à la musique ont été appréhendées comme des vecteurs de socialisation et de sociabilités multiples au fil du parcours migratoire. La méthodologie qualitative exploratoire comprend quarante-cinq entretiens semi-dirigés sous forme de récits de vie axés sur la musique, soixante-dix séances d’observation dans des évènements musicaux variés, de même qu’un e-terrain, soit l’observation d’interactions sociomusicales sur diverses plateformes numériques. L’analyse se développe autour des questions suivantes : quel rapport les technologies numériques et la musique entretiennent-elles au fil d’un parcours migratoire ? Dans quelles circonstances et de quelles manières se combinent-elles dans la vie de personnes immigrantes ? Quels usages recouvrent-elles et quelles en sont les appropriations proprement immigrantes ? Les données révèlent comment les technologies numériques et la musique se combinent et s’alimentent dans le renouvellement de leurs usages, pratiques et symboliques, en contexte immigrant. Par leur interrelation, elles sous-tendent des interactions sociales et musicales multisituées, donnant lieu à une forme de « pluri-ancrage », sociomusical et géoculturel, chez les personnes immigrantes rencontrées à Montréal. Ce faisant, les technologies numériques et la musique se combinent pour actualiser une « diversité culturelle » vécue au quotidien, diversité par ailleurs déjà intrinsèque aux parcours de vie de ces personnes maghrébines dans l’espace francophone.
STUDY OF COPPER COMPLEXES [Cu(LCF3)2] AND [Cu(Lcur)2]H2O AS RADIOPROTECTIVE COMPOUNDS
Authors: Karapetyan Anahit , Santini Carlo , Pellei Maura , Grigoryan Vahan , Dallakyan Ashot , Khachatryan Gayane
Published: September 2024

One of the first and direct signs of the impact of ionizing radiation (IR) on a cell is the destabilization of chromosomes. Radiation-induced damage to the karyotype is an important indicator both for biological indication of the severity of radiation injuries and for predicting the development of long-term adverse effects of IR. The search for new, effective radioprotective compounds is a priority task of modern radiobiology. In this area, metal-based compounds with high antioxidant activity are of particular interest. The purpose of this work is to determine the possible radioprotective properties of Cu(II) complexes, [Сu(LCF3)2] and [Cu(Lcur)2]H2O, supported by the anions of the β-diketone ligands 1,1,1,5,5,5-hexafluoro-2,4-pentanedione (HLCF3) and 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione or curcumin (HLcur). In this research work we determined survival, life expectancy and cytogenetic parameters: mitotic index, chromosome aberrations and % of polyploid cells in the bone marrow cells of the femur (count in 1000 cells in each preparation). Group I included intact animals; Group II consisted of animals exposed to the radioisotope technetium; Group III consisted of animals that were intraperitoneally injected with copper complex [Cu(LCF3)2] at a dose of 50 mg/kg in a volume of 2 mL one hour before the administration of the Tc isotope (“irradiation + copper compound [Cu(LCF3)2]); Group IV included animals that received the compound [Cu(Lcur)2]H2O before irradiation. The groups with the injection of [Cu(LCF3)2] complex had the highest survival. In terms of chromosomal aberrations and number of polyploid cells, as indicators, a significant difference was found in those irradiated compared with the “irradiation + [Cu(LCF3)2]” group (both after 15 and after 30 days), which indicates the radioprotective property of the compound. In terms of the mitotic index, a tendency towards normalization was noted after 15 days and a significant difference between Groups 2 and 3 by the end of the study (after 30 days), which also proves the beneficial effect of this compound. Analysis of survival and changes in cytogenetic parameters multiregression analysis using both complexes confirms the greatest efficiency of the [Cu(LCF3)2] complex with respect to [Cu(Lcur)2]H2O, because when using [Cu(Lcur)2]H2O in Group IV and comparing it with “pure irradiation” only a tendency toward normalization of cytogenetic parameters was observed. Multiregression analysis of cytogenetic parameters also confirmed the highest efficiency of the [Cu(LCF3)2] compound in comparison with [Cu(Lcur)2]H2O. The results of the research indicate the need to continue work in the direction of searching for agents that have a therapeutic effect in radiation injuries.
MINIMALLY INVASIVE TREATMENT OF MECHANICAL STOMACH SUTURE FAILURE IN PATIENTS AFTER LONGITUDINAL RESECTION FOR OBESITY (A CLINICAL CASE)
Authors: Mikhaylichenko Vyacheslav , Voronkov Denis , Kеrimov Enver , Parshin Dmitry
Published: September 2024

Sleeve gastrectomy has now become one of the most popular operations in the treatment of morbid obesity. We present a clinical case of minimally invasive treatment of early suture failure after sleeve gastrectomy, from the archive of the authors’ clinical observations. Suture failure occurred on the day 4 after surgery. Endogastroscopy revealed a defect of 12 mm in diameter with infiltration at the edges. The technique of endoscopic sanitation of the abscess cavity and transcutaneous drainage of the abdominal cavity was used. After 14 days, the drainage in the abdominal cavity stopped functioning. Fistulography showed that it was not in the abscess cavity; according to endoscopic fistulography, hermetic sealing was achieved. After 2 months the fistula was completely closed. The patient was discharged with complete recovery. After 6 months, EGD revealed cicatrical changes; body weight loss: 55 kg. This clinical case demonstrated the possibility of combined minimally invasive treatment of a postoperative complication – gastric suture failure after sleeve gastrectomy.
THE ROLE OF LIFESTYLE-RELATED TREATMENTS FOR IRRITABLE BOWEL SYNDROME
Authors: Chamera-Cyrek Katarzyna , Sikora Oliwia , Baran Jan , Rowiński Dawid , Kuzminski Clara , Podczerwińska Aneta , Prokop Dominika , Borek Mikołaj , Kamil Marzec Kamil Bartlomiej , Jabloński Wiktor , Kupczak Wojciech
Published: September 2024

Introduction: The role of diet and lifestyle in Irritable Bowel Syndrome (IBS) mainly involves alleviating symptoms and improving the quality of life for patients. Diet plays a significant role through the identification and avoidance of trigger foods, the introduction of an appropriate amount of fiber, and adherence to specific guidelines. Lifestyle, including regular physical activity, stress reduction techniques, and healthy sleep habits, also contributes to the reduction of bowel discomfort. Aim of the study: The aim of this study is to examine the relationship between diet and lifestyle, and the occurrence and course of Irritable Bowel Syndrome. Material and Methods of Research: A literature review focused on keywords related to the topic was performed using databases such as PubMed and Google Scholar, as well as textbooks and articles on websites. Results: Irritable Bowel Syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract, primarily characterized by abdominal pain and changes in bowel habits. Dietary modifications, such as a lowFODMAP diet, and lifestyle factors, including physical activity levels, stress management, and meal regularity, significantly influence the course of the disease. There are gender differences in symptomatology and psychosocial impact as well as gender-specific responses to pharmaceutical treatments. Ongoing research is needed to better understand the mechanisms underlying IBS and to optimize therapeutic strategies. Conclusion: The effectiveness of IBS therapy requires a comprehensive approach that includes dietary modifications, increased daily physical activity, learning to manage emotions, and regular collaboration with a doctor. Understanding and implementing these elements are crucial for effectively alleviating symptoms and improving the functioning of patients with Irritable Bowel Syndrome.
Використання гіперкомплексних числових систем для математичного моделювання граничних режимів електричних систем
Authors: S. I. Klipkov
Published: September 2024

Розглянуто обмеження класичної теорії функцій комплексного змінного для аналізу ком-плексних рівнянь усталеного режиму електричних систем, обумовлені неаналітичністю комплекс-ної потужності, як функції комплексних напруг. Показано, що вектор дійсних комплексних скла-дових гіперкомплексних рішень відображається в підмножину області існування усталених режи-мів з виродженою комплексною матрицею першого наближення, при формуванні якої використо-вується поняття псевдопохідної. Таким чином, істотно спрощується математичне моделювання граничних режимів електричних систем. Табл.: 2. Іл.: 1. Бібліогр.: 15 найм.
Методичні аспекти концептуального проектування автоматизованих систем
Authors: Yu. Ya. Samokhvalov  , E. M. Naumenko  , O. I. Burba
Published: September 2024

Розглянуто підхід до структуризації процесу концептуального проектування автоматизова-них систем. Запропоновано методи формалізації етапів формування варіантів концепції системи, вибору варіанту, що найкраще враховує вимоги користувача і визначення очікуваних результатів реалізації вибраного варіанта. Табл.: 3. Іл.: 3. Бібліогр.: 17 найм.
Analisis Fungsi Koordinasi, Penilaian Kerja dan Pelatihan Kerja Terhadap Kinerja Karyawan pada Dinas Kesehatan Kabupaten Pasuruan
Authors: Aisyah Siti , Setyowaty Reny , Imron Muhamad , Fariz
Published: September 2024

English Version
               An effective and efficient organization is reflected in its ability to achieve its goals. This is evident through its performance and work environment. On the other hand, poor organizational performance indicates various issues related to employee processes, performance, and tasks. Hence, the objective of this research is to investigate and analyze the factors that impact employee performance. The survey was conducted at the Pasuruan District Health Office, which employs 72 individuals. The study utilized a random sampling technique to select employee data IDs randomly. Hypothesis testing was performed through multiple regression analysis. The results demonstrated that the variables of adjustment and job evaluation did not significantly affect employee performance, whereas training had a notable impact on job improvement. Additionally, our findings indicate that all independent variables (adjustment, evaluation, and training) collectively influence employee performance.
 
Versi Indonesia
Organisasi yang baik tercermin dari efektifitas dan efisiensinya dalam mencapai tujuannya. Hal itu tercermin dari kinerja dan lingkungan kerja. Kinerja organisasi yang buruk menunjukkan banyak masalah dengan proses, kinerja, dan pekerjaan karyawan. Oleh karena itu, tujuan dari penelitian ini adalah untuk menyelidiki dan mempertimbangkan faktor-faktor yang mempengaruhi kinerja karyawan. Survei dilakukan di Dinas Kesehatan Kabupaten Pasuruan yang mempekerjakan 72 orang. Penelitian menggunakan teknik random sampling di mana ID catatan karyawan dipilih secara acak. Hipotesis diuji dengan menggunakan analisis regresi berganda. Hasil penelitian menunjukkan bahwa variabel moderator dan variabel evaluasi jabatan tidak berpengaruh signifikan terhadap variabel kinerja karyawan, namun pelatihan berpengaruh signifikan terhadap peningkatan kinerja. Kedua, seluruh variabel independen (adaptasi, penilaian, pelatihan) berpengaruh terhadap kinerja karyawan secara simultan.
Sumbangsih Customer Relationship Management Dalam Menciptakan Customer Intimacy
Authors: Nurivan Rizky  , Amalia Salsabila Ariyanto  , Nur Diana Fahma Salsabila  , Muhammad Rizalul Wakhid  , Yusuf Amrozi
Published: September 2024

English Version
To achieve success in today's dynamic business era, it is important to shift from a product focus to a customer focus. Companies can better understand customers, provide more personalized service, and build communication through a Customer Relationship Management (CRM) approach. This concept aims to achieve Customer Intimacy, namely a close relationship with customers based on a deep understanding of customer needs. Using qualitative descriptive methods, this research reviews literature on CRM and Customer Intimacy. The results show that salespeople's strategies for attracting customer attention, creating Customer Intimacy, and measuring how influential CRM is in building strong customer relationships are important parts of the process. Reliable sources indicate how important this method is for understanding customer needs, increasing customer satisfaction, and increasing customer retention. This study also shows that CRM.
Versi Indonesia
Untuk mencapai kesuksesan di era bisnis yang dinamis saat ini, penting untuk beralih dari fokus pada produk ke fokus pada pelanggan. Perusahaan dapat lebih memahami pelanggan, memberikan layanan yang lebih personal, dan membangun komunikasi melalui pendekatan Customer Relationship Management (CRM). Konsep ini bertujuan untuk mencapai Customer Intimacy, yaitu hubungan yang dekat dengan pelanggan yang didasarkan pada pemahaman yang mendalam tentang kebutuhan pelanggan. Dengan menggunakan metode deskriptif kualitatif, penelitian ini meninjau literatur tentang CRM dan Customer Intimacy. Hasilnya menunjukkan bahwa strategi penjual untuk menarik perhatian pelanggan, menciptakan Customer Intimacy, dan mengukur seberapa besar pengaruh CRM dalam membangun hubungan pelanggan yang kuat adalah bagian penting dari proses tersebut. Sumber yang dapat dipercaya menunjukkan betapa pentingnya metode ini untuk memahami kebutuhan pelanggan, meningkatkan kepuasan pelanggan, dan meningkatkan retensi pelanggan