bluuebunny/crossref_metadata_2025 huggingface dataset:
Lean six sigma methodology for waste reduction in ship production
Authors: Priyanda Eko , Sutanto Agus
Published: June 2023

This study was conducted to reduce the amount of waste in ship production and assembly processes at PT ES. Several wastes during the ship production process result in the actual ship completion time being longer than the planning time set by the process planner. Therefore, accurate analysis is required to reduce waste. In this way, contributing factors can be identified, and more effective solutions can be obtained to reduce waste. This is done by implementing the Lean Six Sigma method (DMAIC processes) and several tools and methods, such as Pareto and fishbone diagrams and the FMEA method. The results show that the most critical potential root cause affecting production delays comes from the potential causes with the highest Risk Priority Number (RPN) value. The causes are welders who do not understand the WPS (RPN 432), unstable welding transformers (RPN 432), and unproductive loader movements (RPN 384). The recapitulation of welding defects produced in the production process at a sigma level of 2.48. Recommendations for the three potential critical wastes were made and planned for implementation. The estimated average RPN impairment for the three critical root causes was 32.3%. This condition will impact the total ship production time, which is 6% shorter (equivalent to 14 days) than the previous production time with a new sigma level of 2.55.
ГОСУДАРСТВЕННОЕ УЧАСТИЕ В ОРГАНИЗАЦИИ ПРИНЯТИЯ РЕШЕНИЙ ОБЩИМИ СОБРАНИЯМИ СОВЛАДЕЛЬЦЕВ ОБЩЕГО ИМУЩЕСТВА
Authors: Мятишкин Юрий
Published: June 2023

Публикация посвящена развитию общественно-государственного партнерства в плане административно-правовой поддержки системы принятия решений общими собраниями собственников общего имущества
Student Anxiety towards the Impact of Covid-19 Pandemic and its Implication in Counseling Guidance Services
Authors: Sulaiman Sulaiman , Yanizon Ahmad , Ramdani Ramdani , Rofiqah Tamama
Published: June 2023

Anxiety can manifest as a physiological response to anticipate problems that may arise, or as a disorder if excessive, such as the Covid 19 pandemic which affects student anxiety. The research method used Quantitative with a research population of 67 Counseling Guidance Students, then a sample of 34 students was taken. Sampling technique with simple random sampling. Data analysis techniques using the Percentage Technique. Based on the results of the percentage analysis, 8 (23%) students are in the category of very high student anxiety, 15 (44%) are in the high category and 7 (20)% are in the medium category. 3 (9%) students have a student anxiety level in the low category and 1 (4%) student has a student anxiety level in the very low category.
The Effect of Self-Confidence Towards Public Speaking on Students of Islamic Education Study Program, Universitas Muhammadiyah Purwokerto
Authors: Utari Pragita Bela , Suwarti Suwarti , Wulandari Dyah Astorini , Mildaeni Itsna Nurrahma
Published: June 2023

Students of the Islamic Religious Education Study Program should have good public speaking skills because students will become PAI teachers. Public speaking is the ability to speak in public using language that can be understood by listeners. Public speaking can be influenced by self-confidence, so students must have high self-confidence because it is intended that the ability to speak in front of many people goes well without feeling embarrassed, feeling awkward, and much more. This study aims to examine the effect of self-confidence on public speaking for students of UMP Islamic Education Study Program. This study used a simple random sampling technique as many as 181 students in the UMP Islamic Education Study Program. The data collection method uses a public speaking scale with a reliability of 0.941. Confidence scale with reliability of 0.902. The analytical technique used is simple linear regression analysis with SPSS version 25 program. The results of the study show that the F value is 626,992 with a t value of 25,040, the significance value (p) = 0.000 (p < 0.05), meaning that the proposed hypothesis can be accepted. with an Rsquare value of 0.778. This shows that self-confidence has an influence of 77.8% and 22.5% is influenced by other factors outside the study.
In Silico Study of Mangosteen Fruit (Garcinia mangostana L.) as Pancreatic Anticancer Against AKT Kinase
Authors: Elaine Angela Alysia , Nisa Akhyatun , Tahara Nabila , Aini Dzulfah Qurrotul , Syahriar Zulvan
Published: June 2023

Keganasan pada pankreas diakibatkan karena tidak terkendalinya proliferasi sel yang akan mengarahpada berkurangnya proses apoptosis sel. Oleh karena itu, salah satu usaha untuk menangani kasuskanker pankreas ini adalah dengan menghambat protein antiapoptosis seperti AKT kinase. Inhibisiprotein AKT kinase didasarkan pada mekanisme penghambatan fosforilasi protein AKT kinase padasel pankreas. Senyawa golongan xanton dari buah manggis (Garcinia mangostana L.) telah terbuktimemiliki aktivitas antikanker. Pada penelitian ini senyawa golongan santon diteliti potensinya sebagaiobat anti kanker pankreas melalui metode penambatan molekuler yang dilakukan terhadap reseptorprotein AKT kinase dengan bantuan AutoDockTools (versi 4,2.6 dan 1.5.6), divisualisasikan denganBIOVIA Discovery Studio 2020, lalu analisis profil farmakokinetika serta toksisitas dan drug-likenessyang mengacu pada Lipinski’s Rule of Five melalui situs web pre-ADMET. Penambatan molekulermenghasilkan 5 senyawa turunan santon yang memenuhi kriteria. Senyawa 1-isomangostin memilikipotensi aktivitas yang lebih baik jika dibandingkan dengan ligan pembanding dan ligan uji lainnyadengan energi ikatan (ΔG) -9,90 kkal/mol dan konstanta inhibisi 54,9 nM. Hasil prediksi ADMET dari1-isomangostin menunjukkan sifat absorpsi yang baik (HIA = 94%, Caco2 = 39,97), distribusi yangbaik (PPB = 79,1%), tidak mampu menembus sawar otak (BBB = 0,179), dan tidak bersifat toksik.
Studi Penambatan Molekuler Senyawa Antidiabetes pada Reseptor PPAR-γ dari Tanaman Ciplukan (Physalis angulata Linn.)
Authors: Lestari Ira Novianty , Renada Ega , Juliana Dinda , Iswara Kifti , Sukmara Sendi
Published: June 2023

Diabetes melitus adalah penyakit kronis yang disebabkan oleh pankreas tidak cukup memproduksiinsulin atau ketika tubuh tidak dapat menggunakan insulin secara efektif. Salah satu tumbuhan yangberpotensi sebagai antidiabetes adalah ciplukan (Physalis angulata Linn.). Pada penelitian ini dilakukanstudi penambatan molekular terhadap 10 senyawa dari tanaman ciplukan (Physalis angulata Linn.) untukmengetahui senyawa terbaik sebagai kandidat obat antidiabetes pada reseptor PPAR-γ. Pengujiandilakukan menggunakan AutoDock Tools-4.2.6 untuk simulasi penambatan molekuler, PreADMET danLipinski’s Rules of Five digunakan untuk memprediksi farmakokinetik dan toksisitas ligan yang diuji.Hasil menunjukkan bahwa senyawa terbaik sebagai antidiabetes pada reseptor PPAR-γ adalahWithangulatin-A dengan nilai energi ikatan dan konstanta inhibisi masing-masing sebesar -8,59 kkal/mol dan 0,502 uM, ikatan hidrogen terjadi pada residu asam amino Cys285 dengan hasil PreADMETdan Lipinski’s Rules of Five memenuhi persyaratan.
Skrining Fitokimia dan Profil KLT Ekstrak dan Fraksi Daun Manggu Leuweung (Garcinia celebica L.)
Authors: Peratiwi Shafira Galuh , Tahara Nabila , Mustikawati Bunga , Maisyarah Intan Timur , Indradi Raden Bayu , Barliana Melisa Intan
Published: June 2023

Tanaman manggu leuweung (Garcinia celebica L.) merupakan tanaman yang termasuk genus Garcinia danfamili Clusiaceae. Genus Garcinia spp. telah banyak diteliti karena memiliki potensi untuk dikembangkansebagai alternatif pengobatan namun belum banyak penelitian yang dilakukan pada ekstrak danfraksi daun G. celebica. Dilaporkan ekstrak dari daun G. celebica memiliki aktivitas sebagai antioksidan,antimikroba, antikanker dan antiplasmodial. Tujuan dari penulisan ini untuk mengetahui kandungansenyawa metabolit sekunder dan profil KLT yang pada ekstrak etanol, fraksi n-heksan dan fraksi etilasetat daun G. celebica. Penelitian dilakukan melalui tahap ekstraksi dengan metode maserasi, fraksinasisecara Ekstraksi Cair-Cair (ECC), pemeriksaan ekstrak dan fraksi dengan Kromatografi Lapis Tipis(KLT) dan skrining fitokimia. Berdasarkan hasil skrining fitokimia ekstrak daun G. celebica mengandungsenyawa flavonoid, saponin, polifenol, monoterpen/seskuiterpen. Fraksi n-Heksana daun G. celebicamengandung senyawa flavonoid, polifenol dan monoterpen/seskuiterpen sedangkan fraksi etil asetatdaun G. celebica L. mengandung senyawa flavonoid, saponin, polifenol, monoterpen/seskuiterpen.
Control-Enhancing Mechanisms in State-Owned Companies – Analysis of Companies Listed on the Warsaw Stock Exchange
Authors: Miążek Radosław
Published: June 2023

Purpose

In countries with a developed economy, including Poland, the state seeks to retain control of enterprises (companies) operating in so-called strategic sectors, such as fuel and energy, chemical industry, transport, and telecommunications infrastructure. Proper control of these entities not only determines the effective implementation of economic policy, but it is also important to ensure the economic sovereignty of the state and public security.

The purpose of this study is to identify and analyze control-enhancing mechanisms in SOEs listed on the Warsaw Stock Exchange (WSE), taking into account the division between majority and minority state ownership.

Methodology

Analysis of documentation.

Findings

Based on the analysis of statutes and shareholder structures of the investigated entities, it is established that for companies with minority state ownership, the state uses control-enhancing mechanisms to gain effective control of the company. Similar mechanisms are also applied in companies with majority state ownership, where these mechanisms contribute to achieving full control of the company. The most commonly used mechanism is a dominant shareholder status and limitation of voting rights for shareholders other than the state.

Originality

Apart from state-owned companies, this analysis also included companies indirectly controlled by the state.
Determinants of inheritance and gifts taxation in the European Union
Authors: Kudła Janusz , Woźniak Rafał , Walczyk Konrad , Dudek Maciej , Kruszewski Robert
Published: June 2023

Inheritance and gift taxation vary widely among countries in both the design and tax burden. We analyze the impact of a series of factors, such as the country’s affluence, political preferences, preferences for equity, aging ratio, fiscal standing of the state, and the country’s size, on inheritance tax systems. The applied methods involve the random effects ordered logistic regression for tax design and tobit correlated-random effect models for tax revenues. We find that inheritance tax design is mainly determined by demographic factors while tax revenues depend on a broader group of factors including political orientation of a state, condition of an economy, and the size of a country. Higher preferences for equal distribution and commitment to democratic norms are associated with higher tax revenues. Good economic condition of the state boosts revenues, as does country’s higher population. The results shed some light on future evolution of inheritance taxation.
Local context of local government participation in the innovation networks: Evidence from Poland
Authors: Godlewska Malgorzata , Mackiewicz Marta
Published: June 2023

Innovation networks help to create innovation ecosystems by strengthen interactions between government, academia, business, and special institutions. The purpose of the article is to identify the relationship between the local context, i.e., the conditions and environment in which the Local Government Unit operates and their participation in the innovation networks. The analysis is based on a survey of 184 local government authorities in Poland, Local Administrative Unit level 2. The present study examines the hypothesis that the more supportive the local context is in the Polish municipalities and cities on district rights, the greater the engagement of local government authorities in local or regional innovation networks. The supportive local context was defined by a set of institutional, economic, geographical, demographic, cultural, political, managerial, and administrative factors. The research findings indicate that the key factors that influence the engagement of local government in local or regional innovation networks are institutional factors.
High resolution 2D plastic scintillator detectors for radiotherapy departments
Authors: Woźniak Grzegorz Zbigniew , Kozłowska Beata
Published: June 2023

Introduction

Plastic scintillation detectors (PSD) have been developed for over four decades and are widely used in a variety of fields, but one can find relatively few reports of their clinical use compared to other dosimetric solutions.

Material and methods

The inexpensive detector setup made of a Saint-Gobain BC-400 plastic scintillator and commercially available on the market CMOS-based DSLR Pentax camera was investigated. Build PSD detectors were irradiated with 6, 10 and 15 MV flattening filtered (FF) and 6 and 10 MV flattening filter free (FFF) photon beams using a clinical linear accelerator. Data were processed using Matlab software to remove background and artefacts. A comparison of the spatial resolution parameters to the Gafchromic EBT3 films was performed.

Results

Average dose difference between TPS and PSD was 1.1%. The measured spatial resolution was 0.29 mm, and it differed from the film by 1.1%. MTF50 for PSD was 0.57 mm higher than the Gafchromic film. Signal to dose fit function with an R-square equal to 0.999 was established. The standard deviation of mean pixels value for a series of measurements was below 0.1%, for variable dose rate dependence was below 0.6% and for different energies 1.1%.

It was demonstrated that such a setup allows a satisfactory signal-to-dose dependence and provides high spatial resolution at an affordable price compared to a 2D ion chamber or a diode detector array. Moreover, PSDs are reusable and provide a simple readout compared to Gafchromic films commonly used in radiotherapy departments.

Conclusions

Variable parameters of the camera allow to select signal values at the optimal level. The system presented excellent signal stability, high image resolution and a simple signal-to-dose relationship which encourages further work to investigate PSDs for use in radiation therapy departments.
ESTETIKA FILM PARASITE DENGAN ANALISIS FOKALISASI (MELALUI SUDUT PANDANG TOKOH)
Authors: Prajahita Putri Sima , Mustikawati Retno , Pungkiawan Pius Rino
Published: June 2023

Penelitian ini mengkaji bagaimana fokalisasi diterapkan ke dalam film Parasite dan bagaimana analisis fokalisasi menjadi dasar kajian estetika film Parasite melalui Skripsi Pengkajian Seni berjudul Estetika Film Parasite dengan Analisis Fokalisasi (Melalui Sudut Pandang Tokoh). Penelitian akan dianalisis menggunakan metode penelitian kualitatif dengan mengumpulkan dokumentasi dan observasi. Satuan data yang akan dianalisis berupa scene-scene yang ada di dalam film Parasite. Tahap penelitian ini dimulai dengan mengamati film Parasite, menganalisis naratif film Parasite, menganalisis fokalisasi film Parasite, menganalisis relasi fokalisasi antartokoh pada film Parasite, mengkaji estetika film Parasite, dan diakhiri dengan penarikan kesimpulan. Hasil penelitian ini ditemukan penerapan fokalisasi pada tiga karakter utama dan pendukung yaitu keluarga Kim, keluarga Park, dan keluarga Moon-gwang. Penerapan fokalisasi terbanyak adalah fokalisasi eksternal dengan jumlah fokalisasi keluarga Kim 143 scene, fokalisasi keluarga Park 86 scene, dan fokalisasi keluarga Moon-gwang 49 scene. Fokalisasi Internal diterapkan pada fokalisasi keluarga Kim sebanyak 26 scene dan fokalisasi keluarga Moon-gwang sebanyak 1 scene. Relasi fokalisasi yang terjadi antara tokoh utama dan pendukung membentuk alur cerita yang dramatis melalui fokalisasi internal dan eksternal. Jadi, estetika film Parasite berkaitan dengan pengungkapan karakter dan pembangunan alur cerita yang padat dan dramatis.
AKUNTANSI SANG KHALIFAH ABU BAKAR ASH-SHIDDIQ RA
Authors: Mobarok Fajar , . Syahril
Published: June 2023

Perkembangan akuntansi islam pada Masa khalifah Abu Bakar tidak banyak mengalami perubahan yang signifikan, seluruh kegiatan perekonomian negara masih dilakukan secara sederhana baik dari pengelolaan pendapatan negara hingga pendistribusiannya, pada masa itu belum dibentuk sistem administrasi, persediaan dana cadangan dan lain sebagainya. dalam penelitian ini adalah studi literatur. Jenis penelitian ini dilakukan dengan cara mengumpulkan berbagai jenis referensi dan teori yang sesuai dengan temuan-temuan yang menjadi permasalahan dalam penelitian ini. Hasil penelitian menunjukkan bahwa penerapan prinsip keadilan akuntansi islam antara masa Abu Bakar dengan akuntansi islam era modern dalam pengelolaan baitul mall berupa zakat masih sangat relevan salah satu bukti dengan adanya kesamaan tujuan yaitu untuk kesejahteraan umat.
Pertentangan Rasionalitas Instrumental dan Nilai di Era Covid-19
Authors: Tory Febri , Afrizal Afrizal , Alfiandi Bob
Published: June 2023

This article discusses the conflict between instrumental rationality and value rationality. The purpose of the article is to re-examine what the differences are between the two and what are the causes of the conflict. The finding shows that contradictory actions would not have occurred if there were no people who had a tendency to place more importance on the dominant rules and were accompanied by the awareness to implement them. The only way to stop it is to "understand" what is behind it to take an action and analyze it from the stability of reality and worldview. Whether reality must be in accordance with the worldview or a worldview that adapts to reality so that there is no mismatch between the two. When reality can no longer be explained by the prevailing worldview. Then the worldview will be reinterpreted so that it can explain reality or vice versa, the reality that must be changed to follow the worldview. Back at this time, the Bukittinggi City Government has unwittingly relaxed the 3M policy (although this rule is still being encouraged in the community) by prioritizing the mandatory wearing of masks and launching the covid-19 vaccination as a new step to stop the spread of the covid-19 outbreak.
Analisis Ketahanan Sosial Masyarakat “Nusantara” Dalam Pembangunan Ibukota Negara
Authors: Valentina Annisa , Elsera Marisa
Published: June 2023

The development of New State Capital (IKN),"Nusantara", has been in progress and urgently needs more facilities to support  its development  like Jakarta, the capital of Indonesia.  The development would bring more heterogenity of community after movement which may lead to social conflict. The purpose of this study is  mapping the condition of social resillence in the "Nusantara" community and to examine the supporting and inhibiting factors for the development of social resilience. The approach applied in this article was a qualitative literature study, by examining the text from online news. The object of this study was development of IKN and its impact in social resilience. Data were collected through online assessments. After that, data were sorted, categorized, and analyzed.  The results of the study show that the social resilience of local people  is still weak; great effort is needed to  strengthen  local people’s resilience too increase ability of them to facie challenges in the IKN.
Praktik Sosial Remarriage pada Masyarakat Minangkabau di Kenagarian Padang Ganting
Authors: Desmaisi Desmaisi , Jendrius Jendrius , Maihasni Maihasni
Published: June 2023

: Remarriage is an individual who is married the same or more than twice by a man or a woman. Usually, marriage is done once in a lifetime. However, in Nagari Padang Ganting found men and women married many times. This study uses a qualitative method. Data was collected using in-depth interviews, observation and secondary data analysis. The practice of social remarriage (marriage again) in the Minangkabau community in Kenagarian Padang Ganting studied with structuration theory by Anthony Giddens is known that there are structures that enable or empower "remarriage" itself. But there are also structures that constrain or curb “remarriage”. Of the two divisions, the empowering structure tends to be more dominant than the restraining structure. Men don't have space in their parents' homes, there are parties looking for a mate, the value of children as continuation of offspring, male providers, stigmatization of widows and two, men remarry to take care of their needs, second and subsequent marriages are easier to do and the practice of remarriage is a common thing to do into a structure that perpetuates remarriage. Meanwhile, remarriage is considered to increase men's economic responsibilities, the marriage law makes it difficult for divorce to occur and women carry out the parenting role posterity becomes a structure that restrains perpetrators frim remarriage.
IMPACTO DA INFODEMIA NA HESITAÇÃO VACINAL CONTRA A COVID-19: UMA AMEAÇA COMPARTILHADA
Authors: Coelho Lara Beatriz de Sousa , Coelho Walquíria Cosme de Sousa , Alencar Francisco Ítalo Gomes , Alves Sannya Paes Landim Brito , De Carvalho Mateus Balbino Barbosa , Silva Thaianne Gabrielle Santos , Da Silva Letícia Silva , Uchoa Carlos Eduardo Silveira , Chaves Mickael Nathan Rodrigues , Dos Santos Alcimaria Silva , Oliveira Francisco Braz Milanez
Published: June 2023

Objetivo: Examinar e mapear as evidências científicas sobre o compartilhamento de desinformações relacionadas a vacinação contra a COVID-19 entre usuários das redes sociais. Metodologia: Scoping Review, baseado nos procedimentos recomendados pelo Instituto Joanna Briggs. Estabeleceu-se a pergunta norteadora: “Qual o comportamento dos usuários de redes sociais quanto ao compartilhamento de informações e desinformações em saúde relacionados à vacinação contra COVID-19?”. A coleta dos dados foi realizada em abril de 2023 nas bases de dados PubMed, Biblioteca Virtual em Saúde, Scopus, Web of Science e EMBASE. Foram excluídos textos publicados antes de 2020, protocolos de revisão sistemática ou meta análise e estudos fora do recorte temático. Resultados: Os 9 estudos tiveram delineamento de pesquisas experimentais do tipo análise netnográfica. Quanto a plataforma de disseminação, é possível observar que o Facebook é a mídia social que mais veicula fake news relacionadas à vacinação de COVID-19 seguido do Twitter (33,3%) e Instagram (22,2%). Evidencia-se a forte propensão de engajamento a publicações de cunho antivacina e disseminação de eventos adversos e/ou efeitos colaterais dos imunizantes com ênfase na Pfizer-BioNTech. O perfil dos disseminadores está associado a figuras públicas e jovens de 18 a 44 anos, que também possuem maior propensão de crença na fidedignidade das informações encontradas. Os estudos associam a queda nas taxas de imunização pelo medo dos efeitos colaterais, incluindo hospitalização, miocardites, coágulos sanguíneos e óbito, bem como a desconfiança governamental. Conclusão: o compartilhamento de fake news é um forte fator de hesitação vacinal gerando medo, insegurança e preocupação.
RELATO DE CASO CLÍNICO DE PREENCHIMENTO LABIAL COM ÁCIDO HIALURÔNICO E AVALIAÇÕES VOLUMÉTRICAS ATRAVÉS DE SOFTWARE DE ANÁLISE FACIAL 3D
Authors: Lopes Gabriel Cirone , Coelho Marcelle Simões , Sichi Luigi Giovanni Bernardo , Meccatti Vanessa Marques , De Araújo Rodrigo Máximo
Published: June 2023

A análise facial consiste em uma etapa importante do diagnóstico e avaliação dos resultados obtidos na harmonização orofacial. Para avaliação dos resultados de procedimentos estéticos, fotografias são muito utilizadas, porém novas ferramentas são necessárias para facilitar a visualização dos pacientes quanto aos ganhos estéticos. Os scanners faciais 3D surgem como alternativa para tal finalidade. O objetivo deste estudo foi analisar, através de fotografias e escaneamento 3D da face, o ganho de volume labial após intervenção de preenchimento. A paciente apresentava insatisfação com relação aos seus lábios. Durante a avaliação, constatou-se ausência de volume e contorno labial. Antes de iniciar o procedimento, realizou-se protocolo fotográfico e escaneamento facial (E1). Para o procedimento, foi utilizada uma seringa de 1 mL de ácido hialurônico. O escaneamento foi feito no pós-imediato (E2), após 10 dias (E3) e após 40 dias da intervenção (E4). Nesta mesma consulta após 40 dias, foi realizado injeção da segunda seringa de ácido hialurônico escaneamento do pós-imediato (E5). Após 40 dias, a paciente voltou (E6). Após análise comparativa das malhas, foi possível verificar ganho de 3 mm entre E1 e E2. Na comparação do pré (E1) e após 10 dias (E3), verificou-se volumização total de 1,85 mm, demonstrando que quase 40% do volume no pós-imediato é edema. Em E6, após 40 dias da aplicação da segunda seringa, foi possível quantificar ganho de 2,12 mm no lábio superior quando comparado a E1. Pode-se concluir que o escaneamento 3D contribui expressivamente para avaliação dos resultados alcançados em procedimentos estéticos.
Eddy-Current Actuator for Attraction and Repulsion of Non-Ferromagnetic, Conductive Spacecraft
Authors: Wilson Katherine T. , Bernal Guadalupe , Peck Mason A.
Published: June 2023

This paper introduces a propellant-free approach to mobility of an inspection or servicing vehicle. The approach is suitable for motion near the surface of non-ferromagnetic, conductive objects in orbit. This work considers the specifics of eddy-current interactions between a translating permanent magnet and the aluminum surfaces of spacecraft. Such an actuator moves within the body of an inspection vehicle, requiring that its motion remains limited if the vehicle is to continuously interact with the client spacecraft. Experimental verification on a low-friction air track verifies a model for attraction–repulsion dynamics at millimeter-scale initial separations in one dimension. Results show good agreement between the simulated and tested conditions and motivate extension of the model to more general cases. To bound the design space and relative distances at which this actuator is effective, this work identifies the required size, mass, and trajectories for repulsion that restores the actuator to its initial configuration. Results support the utility of eddy-current actuation for microsatellites at separations of millimeters to centimeters from their conductive clients. For such clients the actuator may enable relative mobility and achieve other objectives key to proximity operations.
Studējošo savstarpējā vērtēšana
Authors:   Rīgas Stradiņa universitātes Pedagoģiskās izaugsmes centrs, Jansone Jana
Published: June 2023

Atbalsta materiāls izstrādāts docētājiem, kuri apsver iespēju savā mācīšanas praksē ieviest studējošo savstarpējo vērtēšanu. Materiāla saturs un piemēri veidoti tā, lai iedrošinātu docētājus studiju procesā, papildus ierasti tradicionālajai vērtēšanai, izmantot jaunu vērtēšanas veidu. Studējošo savstarpējā vērtēšana atbalsta un veicina aktīvu iesaistīšanos studiju procesā, kur studējošie uzņemas atbildību par savu sniegumu un, balstoties citu studējošo sniegtajos vērtējumos, pieņem lēmumu par tālāko mācīšanos. Docētāju uzdevums, īstenojot studējošo savstarpējo vērtēšanu, ir rosināt studējošos domāt par vērtēšanu kā procesu, kas nepieciešams, lai sasniegtu augstākus studiju rezultātus. Efektīva studējošo savstarpējā vērtēšana norit, ja tiek veltīts laiks tās plānošanai, sagatavošanai un pārvaldībai, atbalstot studentcēntrētu mācīšanās un mācīšanas pieeju. Būtiski, lai savstarpējā vērtēšana tiktu mērķtiecīgi un sistemātiski organizēta, saskaņojot to ar citām studiju kursā plānotajām darbībām un sasniedzamajiem studiju rezultātiem. Snieguma vērtēšana ietver piemērotu uzdevumu un skaidru kritēriju izvēli, lai studējošie saprastu kā un uz kādiem studiju rezultātiem viņi tiecas. Studējošo savstarpējā vērtēšana atbalsta akadēmiskā godīguma ievērošanu, studējošo aktīvu mācīšanos, zināšanu, prasmju un attieksmju attīstību un konkrētu darbības jomu identificēšanu, kurās nepieciešami uzlabojumi.
Diálogos interdisciplinarios sobre las relaciones de poder que hay entre los tecnócratas del Proyecto de navegabilidad del río Meta y los Achaguas
Authors: Ardila Luna Diana Carolina , Prada Rodríguez Manuel Leonardo
Published: June 2023

Los achaguas son un grupo étnico colombiano que habita en inmediaciones del río Meta que, desde 1980, hace parte de un proyecto que busca recuperar su navegabilidad comercial. Sin embargo, apenas desde la primera década del siglo XXI comenzaron a ser implementadas las obras de adecuación, que fueron realizadas en el territorio achagua. Con base en lo anterior, el objetivo de este artículo es emprender diálogos interdisciplinarios (antropología, historia y filosofía) sobre el proyecto de navegabilidad del río Meta, para analizar la incidencia de la técnica neoliberal en la vida cotidiana de los achaguas, que emplaza estructuralmente a la naturaleza y busca justificarse e imponerse, mediante el gobierno de la tecno-ciencia, como única forma válida de proceder. El ejercicio de análisis de documentos de archivos sobre la Consulta Previa realizada con los achaguas para las obras de adecuación del río permite apreciar que los indígenas interpretaron la técnica neoliberal desde su horizonte de comprensión y negociaron con las instituciones privado-estatales para ajustar el proyecto a sus necesidades, en pro el respeto a su biocultura. Por eso, si ellos llegan a tener la posibilidad de codirigir el proyecto de navegabilidad, habrá más posibilidades de subsistencia tanto para el río como para las futuras generaciones.
Impactos da Cirurgia Cardíaca no Desenvolvimento Neuropsicomotor de Crianças com Cardiopatia Congênita
Authors: Corrêa João Bosco Corrêa de , Ramos Kairo Santos , Ramos Kézia Santos , Zucatelli Poliane Ferrete , Tannus Lorena de Oliveira
Published: June 2023

Objetivo: Relatar os impactos ao desenvolvimento neuropsicomotor oriundos da cirurgia cardíaca corretiva utilizada em crianças acometidas por uma cardiopatia congênita. Métodos: Trata-se de uma revisão integrativa de literatura, com artigos publicados entre 2012 e 2022, nas línguas portuguesa, inglesa ou espanhola e com conteúdo disponibilizado na íntegra. Como problema norteador da pesquisa, utilizou-se: O recém-nascido que nasce com cardiopatia congênita e realiza cirurgia cardíaca tem impacto no desenvolvimento neuropsicomotor? A pesquisa bibliográfica foi realizada entre novembro e dezembro de 2022, sendo realizada buscas nas bases de dados: PubMed, MedLine e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Foram utilizados os Descritores em Ciências da Saúde (DeCS): Cardiac Surgery, Newborn e Neurodevelopmental Disorders com o operador booleano “AND”. Resultados: 15 artigos enquadrados nos critérios de inclusão e exclusão demonstraram que transtornos do neurodesenvolvimento são evidentes em um contexto pós-operatório de crianças com cardiopatia congênita. Considerações finais: A literatura atual possui limitações acerca da abordagem dos impactos estudados a curto prazo para os pacientes inclusos no estudo. Contudo, expõe que apesar dos danos inerentes à cardiopatia congênita, a cirurgia cardíaca corretiva em recém-nascidos expõe os indivíduos a mudanças fisiológicas. Estas são responsáveis por sistematizar piores desfechos ao desenvolvimento neuropsicomotor.
Prevalence of germline mutations in women with breast and/or ovarian cancer in a tertiary care center in Pune, India
Authors: Kulkarni Shriniwas Subhash , Nag Shona , Patra Abhilash , Pant Hira Ballabh , Agiwal Varun , Nirupama A. Y. , Chaudhuri Sirshendu , Murthy G. V. S.
Published: June 2023

In India, the incidence of breast cancer accounted for 1,78,361 cases, whereas ovarian cancer accounts for 45,701 cases, according to Globocan Report 2020. These cancers are known to have a hereditary basis, and >10% of them are associated with pathogenic BRCA1 and BRCA2 mutations. The prevalence of BRCA1 and BRCA2 varies across various Indian studies and is reported to be 2.9–28%. However, gene mutations other than BRCA1 and BRCA2 which are shown to increase the risk of hereditary breast and ovarian cancer (HBOC) are underreported.

Objectives:

The objective of this study was to estimate the prevalence of deleterious germline mutations among women with breast and/or ovarian cancer.

Material and Methods:

A cross-sectional study was conducted in the department of oncology at a super specialty hospital. Patients were enrolled based on the current National Comprehensive Cancer Network guidelines for genetic risk and evaluation of HBOC. Demographic and clinical information was extracted from the electronic medical records of the hospitals from 2018 to 2021. Next-generation sequencing (NGS) was performed on the extracted DNA using a custom capture kit and classified based on the American College of Medical Genetics.

Results:

A total of 94 patients suspected of having HBOC were examined for deleterious germline mutations. The median age of the patient was 46 years (range: 38–57 years). Breast and ovarian cancer patients constituted 64.9% and 35.1%, respectively. The overall mutation detection rate was 25.5%. The positive mutation detection rate was 26.2% and 24.2% in breast and ovarian cancer, respectively, whereas the variant of uncertain significance rate was 18.03% and 24.2%, respectively. Among the pathogenic mutations, BRCA1 was the most common mutation in women with breast cancer (81.3%). In ovarian cancer, it was 50%. BRCA2 mutation was more prevalent in ovarian cancer (50%).

Conclusion:

Our study reports a higher prevalence of germline BRCA1 and BRCA2 mutations in breast and ovarian cancer as compared to other studies. Genetic testing can be offered to high-risk women regardless of family history. This will be useful during diagnosis and help physicians in planning subsequent treatment.
Glycopyrrolate-induced polyuria: An unexpected side effect
Authors: Behera Sunil Kumar , Agarwal Abhishek , Singh Alok , Pandit Vinay R. , Kannauje Pankaj Kumar
Published: June 2023

Polyuria is urine output exceeding 3 L/d in adults, primarily due to solute and water diuresis. In a hospital setting, mannitol and diuretics commonly lead to polyuria. We have found an interesting association of polyuria with glycopyrrolate; to the best of our knowledge, no case is reported in the literature. Here, we are describing a case of Guillain–Barre Syndrome, which developed polyuria during the hospital stay, which was secondary to glycopyrrolate.
The Agenda for Youth Empowerment through Market-Relevant Skill Training: A case study of Skill India Mission
Authors: Sharma Vageesha
Published: June 2023

India's youth demographic makes up one-fifth of the world's population and empowering them is crucial for the country's future success. To become a US $5 trillion economy, the Government needs to develop tailor-made strategies, policies and schemes that maximize the potential of the youth population. The Skill India Mission is one such scheme that aims to empower youth by providing necessary training and skills for the job market. However, the scheme's implementation has been plagued by various challenges such as inadequate infrastructure, low awareness, lack of quality trainers and limited industry participation. This study aims to determine the need for the Skill India Mission scheme, identify the impediments in its implementation and to propose resolutions to the problems. The study concludes that the Skill India Mission is necessary for India's economic growth and social development. Government can address the challenges of implementing the scheme by improving infrastructure, increasing industry participation and enhancing awareness.
„also war halt auch immer so ‚Hallo‘ und dann so bald ‚Tschüss‘“
Authors: Schmidt Sabrina , Gietz Lea , Prangenberg Natalie , Wen Sebastian
Published: June 2023

Dieser Artikel geht der Frage nach, wie jugendliche „Systemsprenger*innen“ ihre Hilfegeschichte im Sozialisationskontext der (stationären) Erziehungshilfe erleben. Hierfür wurden sechs biographisch-narrative Interviews mit jungen Menschen geführt, welche zum Interviewzeitpunkt in Einrichtungen der Heimerziehung untergebracht waren. Gemeinsam ist ihnen, dass sie mehrere Abbrüche und Wechsel im Hilfe- als auch Bildungssystem erfahren haben sowie aus Sicht der Fachkräfte als schwierig wahrgenommene Verhaltensweisen zeigten. Das erhobene Datenmaterial wurde auf Basis des von Gabriele Rosenthal (1995) entwickelten Verfahrens der biographischen Fallrekonstruktion interpretiert. Es bietet einen Einblick in die biographische Bedeutung der erlebten Hilfegeschichte sowie den darin eingebetteten und sich wiederholenden Aufnahmen als auch Abbrüchen und den damit verbundenen Wechseln des Hilfesettings. In diesem Zusammenhang lässt sich die Heimerziehung als „neuer Kontinent“ beschreiben, für dessen gelingende Aneignung es ein Bewusstsein für die Hilfeentscheidung und eine Passung zur biographischen Struktur bedarf. Die Befunde geben Impulse für eine biographieorientierte Weiterentwicklung der Heimerziehung.
Eine Stimme für Stimmlose?
Authors: Posmek Jana , Bastian Pascal
Published: June 2023

Die Fridays for Future-Bewegung führt uns die politische Selbstermächtigung junger Klimaaktivist*innen vor Augen. Zugleich macht sie die Begrenztheit ihrer Teilhabemöglichkeit an politischen Entscheidungsprozessen erst sichtbar. Diese Ambivalenz arbeitet der empirische Beitrag heraus, indem er die Wissenschaftsorientierung der jungen Menschen in den Fokus rückt. Dabei wird analysiert, wie sich die selbst gewählte Verknüpfung zwischen Naturwissenschaften und politischen Forderungen darstellt und mit welchen Implikationen für politische Teilhabe sie einhergeht. Konkret werden aus ethnographischem Datenmaterial zwei Kontroversen, in welche die Aktivist*innen verstrickt sind, herausgearbeitet, entfaltet und unter Bezugnahme auf die theoretischen Arbeiten von Bruno Latour kontextualisiert. Die erste Kontroverse betrifft deren ermächtigenden und zugleich prekären Fakten- und Wissenschaftsbezug. In der zweiten erarbeiteten Kontroverse wird deutlich, inwiefern dieser mit dem Bemühen um politische Teilhabe sowohl der Jugendlichen, als auch nicht-menschlicher Akteure, wie Klimawandel oder CO2, in Verbindung steht. Der Beitrag nimmt somit das Verhältnis von Wissenschaft(sorientierung) und politischer Mitsprache in seiner Ambivalenz in den Blick.
Determination of Ideal Conditions for the Production of Hydroxyl Radicals through Spectroscopy of Ferric Thiocyanate and Methyl Orange
Authors: Maken Nirbaan
Published: June 2023

Exposure to radiation can lead to the breakdown of water into reactive oxygen species (ROS), such as hydroxyl radicals (OH·), through a process called radiolysis. The presence of hydroxyl radicals (OH·) and other ROS can cause mutations to DNA in the human body. While hydrogen peroxide (H₂O₂), a product of radiolysis, may not be a strong ROS on its own, it can react with certain metal ions such as iron(II) to produce hydroxyl radicals in a process called the Fenton reaction. This study investigates the optimal conditions for the Fenton reaction using a cost-effective spectroscopic analysis of ferric thiocyanate and degradation of methyl orange to detect the presence of Fe3+ and OH·. Understanding conditions and methods of detection for the Fenton reaction is relevant due to the carcinogenic nature of the hydroxyl radicals produced (Kumar et al., 2021). The results of the spectroscopic analysis suggest that the Fenton reaction occurs ideally in acidic environments (p = 0.00354) with low temperature dependence. Additionally, both spectroscopic methods are effective for detecting the efficiency of Fenton processes. This study provides valuable insights for future research on the Fenton reaction and its potential applications.
Single-molecule electrochemical imaging resolves the midpoint potentials of individual fluorophores on nanoporous antimony-doped tin oxide
Authors: Lu Jin , Lew Matthew D.
Published: June 2023

We report reversible switching of oxazine, cyanine, and rhodamine dyes by a nanoporous antimony-doped tin oxide electrode that enables single-molecule (SM) imaging of electrochemical activity. Since the emissive state of each fluorophore is modulated by electrochemical potential, the number of emitting single molecules follows a sigmoid function during a potential scan, and we thus optically determine the formal redox potential of each dye. We find that the presence of redox mediators (phenazine methosulfate and riboflavin) functions as an electrochemical switch on each dye’s emissive state and observe significantly altered electrochemical potential and kinetics. We are therefore able to measure optically how redox mediators and the solid-state electrode modulate the redox state of fluorescent molecules, which follows an electrocatalytic (EC’) mechanism, with SM sensitivity over a 900 µm2 field of view. Our observations indicate that redox mediator-assisted SM electrochemical imaging (SMEC) could be potentially used to sense any electroactive species. Combined with SM blinking and localization microscopy, SMEC imaging promises to resolve the nanoscale spatial distributions of redox species and their redox states, as well as the electron transfer kinetics of electroactive species in various bioelectrochemical processes.
Doping in TiO2 to improve solar cell efficiency: A Comprehensive Review
Authors: Mazumder Md Motiur , Akteruzzaman Md , Yeasmin Humaira , Islam Rezoanul
Published: June 2023

To enhance the performance and stability of these solar cells, doping of titanium dioxide (TiO2) with elements such as aluminum (Al), neodymium (Nd), and samarium (Sm) has been explored. This abstract provides a summary of the properties affected by Al, Nd, and Sm doping in TiO2 and their impact on DSSCs and PSCs. Al, Nd, and Sm doping in TiO2 have shown improvements in various properties critical to solar cell performance. The reduction of non-stoichiometric oxygen-induced defects through doping results in the removal of deep electronic traps and sub-bandgap states, leading to an increase in the conduction band. This modification contributes to enhanced charge transport and reduced recombination rates within solar cell devices. Furthermore, the doping process facilitates the passivation of oxygen defects, which plays a crucial role in improving the stability of PSCs. Nd doping has shown promising results in enhancing device stability without compromising short-circuit current. The simple and scalable processing techniques employed for doping TiO2 with these elements make them viable for large-scale production. The achieved efficiencies in DSSCs and PSCs vary depending on the specific calculation methods used, including preconditioning bias, voltage scan speed, and direction. Nevertheless, studies have reported significant efficiency improvements with optimal doping concentrations. For instance, a maximum efficiency of 18.2% was recorded in PSCs with 0.3% Nd doping in TiO2, where maximum values for current density (JSC), open-circuit voltage (VOC), and fill factor (FF) were obtained.
Dipolar ligands tune plasmonic properties of tin-doped indium oxide nanocrystals
Authors: Segui Barragan Victor , Roman Benjamin J. , Shubert-Zuleta Sofia A. , Berry Marina W. , Celio Hugo , Milliron Delia J.
Published: June 2023

Surface functionalization with dipolar molecules is known to tune electronic band alignment in semiconductor films and colloidal quantum dots. Yet, the influence of sur- face modification on plasmonic nanocrystals and their properties remains little explored. Here, we functionalize tin-doped indium oxide nanocrystals (ITO NCs) via ligand ex- change with a series of cinnamic acids with different electron withdrawing and donat- ing dipolar characters. Consistent with previous reports on planar and nanocrystalline semiconductors, we find that withdrawing (donating) ligands increase (decrease) the work function, which we ascribe to an electrostatic potential shift across the molecular layer. Quantitative analyses of the plasmonic extinction spectra reveal that varying the ligand molecular dipole affects the near-surface depletion layer, with an anticorrelated trend between electron concentration and electronic volume fraction, factors that are positively correlated in as-synthesized NCs. Electronic structure engineering through surface modification provides access to distinctive combinations of plasmonic prop- erties that could enable optoelectronic applications, sensing, and hot electron-driven processes.
The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation
Authors: Lu Bing-Qiang , Chen Xi , Chen Feng , Luo Nan , Deng Yu-Wei , Zeng Hua , Zhang Yu , Zhan Jing-Yu , Xu Xiao-Chen , Cao Gui-Zhi , Wen Jin , Zhang Zhiyuan , Feng Xi-Ping , Jiang Xinquan
Published: June 2023

Using remineralization materials to grow hydroxyapatite (HAP) crystals on the surfaces is a common strategy for the repair of early demineralized tooth enamels. As the efficacy is often impaired by harsh dynamic oral environments, e.g., continuous flow of saliva and friction of moving maxillofacial muscles, a rapid remineralization is expected to avoid or diminish these influences. But there has been a great dilemma to address this expectation, as the stabilizers used for preparation and storage of these materials, in turn, could resist their transformation during remineralization. Here, by dissolving the ions of calcium and phosphate in mixed solvents of glycerol and water, we found a stable species with ultrasmall size (1-2 nm), termed glycerol stabilized calcium phosphate cluster (GCPC), which can perform a fast enamel repair via the water-triggered transformation in both static or dynamic environments. The high permeability and water-responsive character allow GCPC to easily enter the nano-/micro-sized enamel defect sites and transform into HAP nanorods immediately, going through a special intermediate—amorphous calcium phosphate nanowire, whose subsequent crystallization product (the nanorods) stands vertically to them and enamel surface. Both in vitro and in vivo studies display that, GCPC forms a compact HAP repair layer within a short time (30 min), which is much faster than the conventional materials (hours or days), and recovers mechanical properties to the values close to those of sound enamel. Moreover, a double-blind, randomized, crossover clinical trial based on in situ model further demonstrates an excellent remineralization efficiency of GCPC in the real human oral environment. Given its rapid repair capacity, simple preparation process, low cost and remarkable biocompatibility, GCPC is promising for large-scale preparation and clinical applications in dental remineralization.
Prompt engineering of GPT-4 for chemical research: what can/cannot be done?
Authors: Hatakeyama-Sato Kan , Yamane Naoki , Igarashi Yasuhiko , Nabae Yuta , Hayakawa Teruaki
Published: June 2023

This paper evaluates the capabilities and limitations of the Generative Pre-trained Transformer 4 (GPT-4) in chemical research. Although GPT-4 exhibits remarkable proficiencies, it is evident that the quality of input data significantly affects its performance. We explore GPT-4's potential in chemical tasks, such as foundational chemistry knowledge, cheminformatics, data analysis, problem prediction, and proposal abilities. While the language model partially outperformed traditional methods, such as black-box optimization, it fell short against specialized algorithms, highlighting the need for their combined use. The paper shares the prompts given to GPT-4 and its responses, providing a resource for prompt engineering within the community, and concludes with a discussion on the future of chemical research using large language models.