bluuebunny/crossref_metadata_2025 huggingface dataset:
Casas vacías, de Brenda Navarro: Maternidad no normativa
Authors: Leonardo-Loayza Richard
Published: November 2023

Resumen: Una de las características más interesantes de la literatura latinoamericana de las primeras décadas del siglo XXI es que sus principales representantes son mujeres, las cuales abordan temas referidos a la condición femenina, pero no en un afán de reiterar los contenidos impuestos por el patriarcado, sino para subvertirlos. Uno de estos temas es la maternidad. El siguiente artículo pretende demostrar que la novela Casas vacías (2020) de la mexicana Brenda Navarro cuestiona la noción tradicional de maternidad, la que está personificada por la figura de la madre no normativa, entendida esta como aquella mujer que no puede o no quiere cumplir con los mandatos que la sociedad establece para ser considerada una “buena madre”. El texto de Navarro presta atención a una variante especial de esta categoría: la madre arrepentida, pero también alude a la madre involuntaria.
Sangue de menina-velha: adoção e menstruação entre os Korubo
Authors: Oliveira Silva Juliana
Published: November 2023

Resumo: Em 2019, realizei a minha primeira e única reclusão menstrual entre os Korubo de recente contato da Terra Indígena Vale do Javari (Amazonas, Brasil). A menstruação e a reclusão menstrual (tsat vule) consistem em permanecer sentada enquanto o sangue desce. No meu caso, durante a reclusão, houve um acidente com um dos anciões que levou ao início dos rituais de canto-choro e, posteriormente, uma das minhas anfitriãs entrou em estado de raiva. Este artigo parte da minha reclusão menstrual como um estudo de caso para analisar as concepções korubo sobre os brancos, a adoção e a menstruação. Argumento que a reclusão menstrual da antropóloga, tratada como menina e velha, pode ser interpretada como uma menarca anômala em que concepções ameríndias sobre os brancos são reconstruídas sob o aspecto performativo do parentesco.
School bureaucracy and reproduction of stigmas in the students and their families
Authors: Rosistolato Rodrigo , Pires do Prado Ana , Cerdeira Diana Gomes da Silva
Published: November 2023

Abstract This article analyzes data from research with 23 managers of municipal schools in Rio de Janeiro that investigated the relationship between educational bureaucracy and families during their children's enrollment processes. In the in-depth interviews, we mapped managers’ perceptions of students and their families, partly oriented by individual and collective stigmas. We will describe the typology we proposed to interpret this set of stigmas, the application of the typology in the analysis of the interviews, and argue about the bureaucrats’ actions guided by these stigmas. Our results show that the bureaucratic actions tend to reproduce social inequalities of origin and produce new forms of inequality within schools.
Teachers in the pandemic: factors and conditions associated with Burnout Syndrome
Authors: Ramos Daniela Karine , Anastácio Bruna Santana , Silva Gleice Assunção da , Pires Leila Urioste Rosso
Published: November 2023

Abstract This article analyzes the Burnout Syndrome indicators in teaching activities during the pandemic to identify factors and conditions that can be associated with its dimensions. The study conducted with 438 Brazilian teachers used convergent mixed methods. We collected data through online questionnaires and the adaptation of a standardized instrument to assess Burnout Syndrome. Among the main results, we found that factors such as gender, age, level of performance, and digital competence can be associated with indicators of psychological distress, life quality, and health.
O jogo na Pedagogia de Rousseau: uma leitura do episódio dos doces
Authors: Paiva Wilson Alves de , Lima Wanderson Pereira
Published: November 2023

Resumo O presente artigo busca comentar o papel do jogo na pedagogia de Rousseau. Com foco no livro Emílio ou Da Educação e enfatizando o trecho do “episódio dos doces”, o texto busca analisar o motivo pelo qual Jean-Jacques coloca o jovem Emílio em exercícios competitivos, entre os jogos, e as brincadeiras realizadas pelo preceptor. Pois, se o amor-próprio nasce da comparação e da competição, a educação natural deveria evitar esse tipo de atividade. Mal encaminhada, qualquer atividade competitiva pode resultar no desenvolvimento do amor-próprio e possibilitar a degradação humana. Por outro lado, como se constata no episódio citado, as atividades recreativas ou esportivas, bem encaminhadas, podem desenvolver as habilidades físicas e as morais. O resultado é a racionalidade sensitiva, a educação do amor-próprio e a utilização do “veneno”, a competição, como “remédio”.
Fracasso escolar e alfabetização de crianças no Projeto Principal de Educação (PPE) para a América Latina e o Caribe (1980-2000)
Authors: Dias Fabrícia Pereira de Oliveira , Gontijo Cláudia Maria Mendes
Published: November 2023

Resumo Este artigo analisa ideias centrais que permearam as discussões promovidas pela Unesco sobre alfabetização infantil e fracasso escolar produzidas no âmbito do Projeto Principal de Educação para a América Latina e o Caribe (PPE – 1980-2000). Problematiza a suposta neutralidade na atuação da Unesco por meio da análise crítica de textos publicados nos Boletins produzidos na vigência desse projeto. Toma como referencial teórico-metodológico pensamentos de Mikhail Bakhtin. Conclui que o fracasso escolar foi considerado problema central da educação na América Latina e no Caribe, com base em balizas economicistas que muito se aproximavam dos interesses de instituições procuradas para financiamento de iniciativas educativas para redução desse grande desafio.
Teaching in Higher Education: which knowledges to mobilize to train teachers?
Authors: Fialho Lia Machado Fiuza , França Maria do Socorro Lima Marques , Nascimento Vanusa Neves
Published: November 2023

Abstract This article analized some teaching knowledges in order to understand which of them are mobilized by the pedagogical practice in higher education, since they are considered essential for teacher training in undergraduate programs. A qualitative study was conducted, whose data, collected with an online questionnaire answered by 25 professors of undergraduate programs at the School of Education of Crateús of the State University of Ceará, were processed by the IRaMuTeQ software and interpreted considering analytical prescriptions from Bardin. The results inferred that, respectively, the knowledges considered most important are: pedagogical knowledge, political knowledge, technical-professional knowledge, and practical knowledge. They were analyzed considering the four emerging categories: implementation of teaching knowledge; teaching knowledge in face of the challenges of the teacher’s work; relevance of teaching knowledge; and acquisition and development of teaching knowledge. In conclusion, teaching knowledge, in its plurality, in order to enhance the educational praxis, must be fostered from the initial training, being improved continuously.
Pesquisar arquivos, habitar o arquivo: o caso da obra A desordem das famílias
Authors: Aquino Julio Groppa , Vieira Elisa , Val Gisela Maria do
Published: November 2023

Resumo Baseado na premissa de que a lida com arquivos consiste em uma alternativa fecunda e viável para a pesquisa educacional, este artigo debruça-se sobreA desordem das famílias, obra de Michel Foucault e Arlette Farge em torno de um conjunto de cartas/ordens régias (lettres de cachet) do século XVIII francês. Primeiramente, são focalizadas as trajetórias de ambos os pensadores e os pontos comuns que culminaram naquela iniciativa. Em seguida, o tratamento empírico do estudo é pormenorizado, com ênfase nos aspectos procedimentais e argumentativos da análise ali realizada. Por fim, advoga-se em favor da pesquisa como um encontro transfigurador entre o/a pesquisador/a e as forças insuspeitas do arquivo mobilizado por ele/a.
Researching archives, inhabiting the archive: the case of the book Disorderly Families 1 2 3
Authors: Aquino Julio Groppa , Vieira Elisa , Val Gisela Maria do
Published: November 2023

Abstract Based on the premise that dealing with archives is a fertile and viable alternative for educational research, this article focuses on the book Disorderly Families, written by Michel Foucault and Arlette Farge, about a set of eighteenth century French royal letters/orders (lettres de cachet). Firstly, we focused the trajectories of both thinkers and the commonalities that culminated in that initiative. Thereafter, the empirical treatment of the study is detailed, with emphasis on the procedural and argumentative aspects of the analysis therein. Finally, we advocate for researching as a transfiguring encounter between the researcher and the unsuspected forces of the archive mobilized by him/her.
Science Fiction: The Hyperaware Enunciator and the Concept of Journey from the Point of View of Referencing Processes
Authors: Barbosa Stener Carvalho Fernandes
Published: November 2023

ABSTRACT Science fiction is a literary genre that has spread around the world due, among other reasons, to its popularity; narratives contain exotic characters and fantastic intrigue. It is considered by the circle of scholars and critics, however, a “minor” literature; for discourse linguists, its aesthetic attributes remain in the background. The theory of points of view (POV), for example, can contribute to a better assessment of the genre. This article aims to study this literary genre via enunciation. First, we talk about studies in narratology to delimit the place of science fiction (or sf) in the universe of narratives. Secondly, we talk about concepts and notations from POV theory within narratological studies to trigger a dialogical analysis of literary discourse. Thirdly, we analyze a fragment from Dune, by Frank Herbert, in its version into Brazilian Portuguese (2017). Finally, we propose that “superpowers” held by characters in this genre can be explained linguistically.
Productive Organizations: The Human-Computer Interaction in Black Mirror
Authors: Assumpção Georgia de Souza , Santos Carolina Maia dos , Andrade Raquel Figueira Lopes Cançado , Henriques Mayara Vieira , Castro Alexandre de Carvalho
Published: November 2023

ABSTRACT The series Black Mirror, broadcast between 2011 and 2023 on Netflix, has become a media phenomenon and its episodes have shown ways of human-computer interaction. The series’ name refers to the fact that when a screen is turned off, it becomes a black mirror that reflects the user’s image. This paper1 aims to analyze the side effects of human-computer interaction in Black Mirror’s production organizations. This research used discourse analysis, mainly from Mikhail Bakhtin’s contributions. The method consisted of three stages that relied on the collaboration of Industrial Engineering students. The research included undergraduate and postgraduate students working collectively, since this procedure integrates teaching and research and helps beginners develop a critical sense. The results indicate that in Black Mirror organizations there is a transition from the concept of human factors to cyborg factors, as well as the use of human-computer interaction to promote social control.
The Writing Process of João Anzanello Carrascoza: Dialogues with Bakhtin
Authors: Salles Cecília
Published: November 2023

ABSTRACT The purpose of this paper is to reflect on João Anzanello Carrascoza’s writing process, based on the concept of creation as network and expanded with Bakthin’s discussions on polyphony. The writer’s files are studied from the perspective of communicative practices, with emphasis on the dialogism of subjects in community, who engage in dialogues of different natures. We present questions that move the author’s literary project, the materialities of the construction of his work and the dilution of boundaries between process and work.
O processo de criação de João Anzanello Carrascoza: diálogos com Bakhtin
Authors: Salles Cecília
Published: November 2023

RESUMO Este trabalho tem o propósito de refletir sobre o processo de escritura de João Anzanello Carrascoza, a partir do conceito de criação como rede, ampliado pelo pensamento bakhtiniano sobre a multiplicidade de vozes. São estudados os arquivos do escritor, sob a perspectiva das práticas comunicativas, com ênfase no dialogismo dos sujeitos em comunidade, travando diálogos de naturezas diversas. São apresentadas algumas questões que movem seu projeto literário, as materialidades da construção de suas obras e a diluição de fronteiras entre processo e obra.
LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification
Authors: Ning Baoshan , Mei Yine
Published: November 2023

Laminin subunit alpha 3 (LAMA3) is a cancer regulator. However, its effects and regulatory pathways in oral squamous cell carcinoma (OSCC) progression remain unknown. This research aimed to determine the influence of LAMA3 regulation via methyltransferase-like 3 (METTL3) on OSCC progression. Using quantitative real-time polymerase chain reaction and bioinformatics analysis, the expression levels of LAMA3 and METTL3 in OSCC tissues were examined. The functional roles of LAMA3 and METTL3 were analyzed using cell functional experiments. Using methylated RNA immunoprecipitation and mRNA stability assays, LAMA3 and METTL3 regulation was investigated. In OSCC tissues, LAMA3 was upregulated. LAMA3 inhibition hampered OSCC cell proliferation, invasion, and migration while its overexpression facilitated OSCC cell progression. METTL3 serves as a crucial upstream regulator of LAMA3 in OSCC and upregulates LAMA3 expression via an m6A-dependent mechanism. The low METTL3 expression partially restored the enhanced malignant phenotype induced by LAMA3 overexpression. Our findings indicate that METTL3 and LAMA3 act as pro-oncogenic factors in OSCC, with METTL3 promoting OSCC malignancy via m6A modification-dependent stabilization of LAMA3 transcripts, representing a novel regulatory mechanism in OSCC.
Robotic Arm-Assisted Total Knee Arthroplasty: Anatomical Alignment and Mid-Term Outcomes from the First Cohort Originating in Greece
Authors: Dretakis Konstantinos , Igoumenou Vasilios G. , Naoum Symeon , Raptis Konstantinos , Koutserimpas Christos
Published: November 2023

Robotic arm-assisted total knee arthroplasty (RATKA) represents a haptic assistive robotic arm used for bone preparation. The purpose of this study was to present implant survivorship, complications and evaluate patients' satisfaction, clinical and functional outcome of RATKA with a minimum of 1-year follow-up. The Oxford Knee Score was recorded preoperatively and at last follow-up. Patients' satisfaction rates, as well as complications and re-operations were studied. Anatomical alignment including varus, valgus deformities and flexion, extension, pre-and postoperatively were evaluated. A total of 156 patients with mean age = 71.9 years were included in the study. The mean follow-up was 35.7 months, while one revision was performed due to infection. Statistically significant improvement of the Oxford Knee Score, as well as of the knee alignment deformities were recorded, while 99.4% of patients reported to be "very satisfied" or "satisfied" with the procedure. RATKA seems to be a safe, as well as reproductible procedure at short-and mid-term follow-up, while the accurate implant positioning may lead to favorable long-term outcomes.
The Impact of Patient Characteristics on Outcomes of Surgically Managed Vertebral Osteomyelitis in the United States: Insights from a National Database Study
Authors: Kurowicki Jennifer , Changoor Stuart , Coban Daniel , Patel Neil , Sinha Kumar , Hwang Ki , Emami Arash
Published: November 2023

This study was conducted to assess the patient characteristics, types of treatment, and outcomes of patients who are surgically treated for vertebral osteomyelitis (VO) in the United States. VO can be treated with or without surgical intervention. Surgically treated cases of VO are associated with significant morbidity and mortality, and incur major healthcare costs. There are few studies assessing the characteristics and outcomes of patients with VO who are treated surgically, as well as the overall impact of surgically managed VO on the healthcare system of the United States. Utilizing the Nationwide Inpatient Sample (NIS) database, 44,401 patients were identified who underwent surgical treatment for VO over a fifteen year period. Severity of comorbidity burden was calculated using the Deyo Index (DI). Surgical approach and comorbidities were analyzed in regard to their impact on complications, mortality rate, LOS, and hospitalization charges. The incidence of surgical intervention for patients who had VO increased from 0.6 to 1.1 per U.S. persons over the study period. Surgically treated patients had a mean age of 56 years, were 75.8% white, were 54.5% male, 37.9% carried Medicare insurance, and they had a mean DI of 0.88. Anterior/posterior approach (OR: 3.53), thoracolumbar fusion (OR: 2.69), thoracolumbar fusion (OR: 19.94), and anterior/posterior approach (OR: 64.73) were the surgical factors that most significantly predicted any complication, mortality, increased LOS, and increased hospital charges, respectively (P < 0.001). The mean inflation-adjusted total hospital cost increased from $20,355 to $39,991 per patient over the study period. VO has been steadily increasing in the United States. Incidence and inflation-adjusted costs nearly doubled. Anterior/posterior approach and thoracolumbar fusion most significantly predicted negative outcomes. VO is associated with lengthy and expensive hospital stays resulting in a significant burden to patients and the healthcare system.
Mechanical properties of mortars with waste plastic as replacement of natural aggregate
Authors: Lavagna Luca , Suarez-Riera Daniel , Mangani Nicoletta , Pavese Matteo
Published: November 2023

The use of waste plastic from waste electrical and electronic equipment as a substitute for natural aggregates in cementitious materials is an increasingly relevant issue. If proved to be suitable, this would allow the recycling of plastics destined for landfill and decrease the use of new natural resources. However, replacing sand with plastic tends to reduce the mechanical properties of mortars due to the different mechanical properties of natural aggregate and waste plastic and the poor interfacial compatibility between plastic and cement paste. Several strategies to improve the mechanical properties of mortars containing waste plastic were investigated in this study. The addition of 1% of superplasticiser coupled with a lower water/cement ratio was found to restore mechanical properties to values equal to a standard mortar prepared with natural aggregate, thus obtaining material that can be used in construction.
»Die Wirklichkeit allein reicht nicht aus«. Interview mit Sandra Wollner
Authors: Spiegel Simon
Published: November 2023

Austrian filmmaker Sandra Wollner talks about her movie The Trouble with Being Born.
Çevik Üretimin Sürdürülebilirlik Performansına Etkisinde Ürün ve Süreç İnovasyonunun Aracı Rolü
Authors: PANCAROĞLU Mehmet Serhat , PERÇİN Selçuk
Published: November 2023

Son yıllarda meydana gelen teknolojik gelişmeler ve artan rekabet müşteri tercih ve beklentilerini etkilemiştir. Müşteriler her geçen gün daha fazlasını daha hızlı ve daha az maliyetle istemektedir. Bu durum özellikle hazır giyim gibi moda ağırlıklı ürün üreten sektörlerde kendini göstermektedir. Ürünlerin yaşam süreleri kısalmış ve talep kararsızlaşmıştır. Bunun sonucu olarak yeni süreçler kullanarak yeni ürünlerini müşteriye daha hızlı teslim edebilen firmalar rekabet avantajı sağlamaktadır. Bu çalışmanın amacı hazır giyim sektöründe Çevik Üretimin (ÇÜ) Sürdürülebilirlik Performansına (SÜP) etkisinde Ürün İnovasyonu (Üİ) ve Süreç İnovasyonunun (Sİ) aracı etkisini analiz etmektir. Bu doğrultuda çalışmanın alt amacı sürdürülebilirliğin sağlanmasında ÇÜ ve inovasyonun önemini ortaya koymaktır. Bu amaçla literatür yardımıyla bir anket oluşturulmuştur. Oluşturulan anket Türkiye’de faaliyet gösteren 125 hazır giyim firma yöneticisine uygulanmıştır. Elde edilen veriler Partial Least Squares Yapısal Eşitlik Modeli (PLS-SEM) ile analiz edilmiştir. ÇÜ’nün SÜP’e etkisinde Üİ ve Sİ’nin ayrı ayrı ve bir arada aracı etkileri olduğu sonucuna ulaşılmıştır. Buna göre ÇÜ hazır giyim firmalarının SÜP’lerini artırmakta Üİ ve Sİ yetenekleri olan firmalarda bu artış daha fazla gerçekleşmektedir.
Investigation of differences in the IR spectra of earthworms as a possible way of their taxonomic identification
Authors:   Omsk State Pedagogical University, Kniazev Stanislav Yu. , Babiy Kirill A. ,   Omsk State Pedagogical University, Golovanova Elena V. ,   Omsk State Pedagogical University, Solomatin Denis V. ,   Omsk State Pedagogical University, Sarf Elena A. ,   Omsk State Pedagogical University, Bel’skaya Ludmila V. ,   Omsk State Pedagogical University
Published: November 2023

IR spectrometry is successfully used for the taxonomic identification of various groups of invertebrates: butterflies, flies, grasshoppers, mosquitoes, weevils, and termites. Therefore, the purpose of this study was to assess the fundamental possibility of taxonomic identification of earthworms based on the study of the functional-group composition of their bodies by the method of IR-Fourier spectroscopy. Seven species of earthworms from five genera were the objects of the study: Aporrectodea caliginosa, Eisenia fetida, Eisenia nordenskioldi, Lumbricus rubellus, Rhiphaeodrilus diplotetrathecus, Octolasion lacteum, Eisenia ventripapillata. IR absorption spectra were registered on an FT-801 IR-Fourier spectrometer in the range of 500–4000 cm–1. The position, intensity, and area of the absorption bands were determined on all spectra. The maximum differences between individual species in intensity and position of protein and nucleic acid absorption bands were established. Using the principal component method, it was shown that the classification was based on the characteristics of the absorption bands of stretching and bending vibrations of methyl and methylene groups, as well as amide groups in the structure of worms. At the same time, the division of earthworms into subgroups with similar spectral characteristics could be explained by several reasons: their origin, kinship, and the influence of the environment. The data obtained during the study confirm the possibility of using IR spectrometry for the identification of earthworms.
The cold-shock gene’s protein complex of different serogroups of Vibrio cholerae
Authors:   Rostov-on-Don Antiplague Research Institute, Vodopyanov Sergey O. , Gerasimenko Artem A. ,   Rostov-on-Don Antiplague Research Institute, Vodopyanov Alexey S. ,   Rostov-on-Don Antiplague Research Institute, Gorokh A. M. ,   Rostov-on-Don Antiplague Research Institute, Pisanov Ruslan V. ,   Rostov-on-Don Antiplague Research Institute, Kruglikov Vladimir D. ,   Rostov-on-Don Antiplague Research Institute
Published: November 2023

553 whole genome sequences of Vibrio cholerae strains O1, O139 and nonO1/nonO139 serogroups were studied for the presence of cold-shock genes cspA, cspV and csh1. The cspA and cspV genes were present in almost all strains. The csh1 gene was present in 99/449 strains of the serogroup O1 and in 21/86 cultures of nonO1/nonO139 taken in the study. The absence of the csh1 gene was revealed in strains of the O139 serogroup and strains of the O1 serogroup with ctxAB and tcpA genes. The study of the nucleotide composition identified 13 different variants of the csh1 gene which cause structural differences in the cold-shock protein Csh1. The two main types of Csh1 protein were represented by the reference type (68 genomes) and the major type (35 genomes), 11 minor variants included single genomes. According to the NCBI database, mainly representatives of minor types of Csh1 protein circulate abroad. The reference type Csh1 was mainly detected in O1 serogroup strains, while 10 strains with the reference type Csh1 protein were identified before 2000, then in 2001-2022 their number reached 55 strains. It is assumed that the new cold shock gene csh1 gives vibrions a selective advantage by ensuring survival at low temperatures in reservoirs.
Flora of the protected area Ice Mountain and Kungur Ice Cave (Perm Krai)
Authors:   Perm State University, Efimik Elena G. , Vladykina Anastasia V. ,   Perm State University
Published: November 2023

The flora of the protected area «Ice Mountain and Kungur Ice Cave» was studied. The protected area is located in the Kungur forest-steppe of the Perm Krai. A list of plant species has been compiled, indicating specific biotopes for each species, as well as sources of information. On the protected area, there are 308 species of vascular plants belonging to 190 genera and 58 families. The presence of three species included in the Red Book of the Perm Krai has been confirmed – Cephalanthera rubra (III category of rarity) and Stipa pennata (III category of rarity) and Anemone uralensis (II category of rarity). Rare species are found in the protected area: Helianthemum nummularium, Polygala sibirica, Epipactis atrorubens, E. helleborine, Helictotrichon schellianum, Quercus robur, Astragalus sulcatus, Aster alpinus. Synanthropic and invasive species are found in protected area: Acer negundo, Amelanchier spicata, Heracleum sosnowskyi, Caragana arborescens, Lupinus polyphyllus, Echinocystis lobata, Hippophae rhamnoides. Synanthropic and invasive species pose a serious threat to the existence of unique forest-steppe communities and protected and rare plants of the Ice Mountain and Kungur Ice Cave protected area.
Immunobiological activity indenopyrroles and indenopyridazines
Authors:   Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation, Gein Oksana N. , Gein Sergey V. ,   Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the RAS, Chizhova Ekaterina G. ,   Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the RAS, Nosova Natalia V. ,   Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
Published: November 2023

The availability of highly effective drugs with minimal side effects is essential in medical practice. In this regard, the search for pharmacologically active substances of plant and chemical origin is being actively pursued. Promising in terms of the search for biologically active compounds are derivatives of pyrrole and pyridazine - indenopyrroles and indenopyridazines. Evaluation of the effect of these compounds on the functional activity of the immune system is relevant, since the immune system plays one of the key roles in maintaining homeostasis in the body. As objects of study, we took indenopyrroles (1a-d) and indenopyridazines (2a-d), which differ in the presence of various substituents in the molecular structure. o assess the effect of the test compounds on the phagocytic activity of rat peripheral blood leukocytes in the in vivo system, the test substances were administered to animals intraperitoneally in 2% starch mucus at a dose of 100 mg/kg. Blood samples were taken from the tail vein. Determination of the phagocytic activity of leukocytes was carried out by the standard method in modification. The results were taken into account microscopically. The cellularity of the spleen was counted, the number of antibody-forming cells in the spleen was assessed by local hemolysis in agarose gel according to Jerne. The effect of the studied compounds on cellular immunity was assessed using a delayed-type hypersensitivity reaction. We have revealed a predominantly stimulating effect, first of all, of indenopyrroles on the phagocytic activity of neutrophils and general leukocyte phagocytosis. Indenopyrroles decreased the cellularity of the spleen and reduced the number of antibody-forming cells. Indenopyridazines had a multidirectional effect on antibody genesis. The test compounds did not change the severity of the delayed-type hypersensitivity reaction.
Cytological features of mononuclear leukocytes cultured in the presence of polyamines
Authors:   E.A. Vagner Perm State Medical University, Morozov Ilya A. , Godovalov Anatoly P. ,   Central Research Laboratory of the E.A. Vagner Perm State Medical University
Published: November 2023

Quantitative and qualitative changes in the cellular composition after incubation with putrescine and cadaverine are considered. The aim of the study was to study changes in the cytological characteristics of leukocytes after their incubation with cadaverine and putrescine. The number, cell types, sizes, presence of vacuoles and inclusions in peripheral blood leukocytes (n=15) were evaluated after their preincubation with cadaverine (5 and 25 mmol/L) and putrescine (5 and 25 mmol/L) for 72 hours at 37oC. It has been shown that as the concentration of putrescine increases, the total number of leukocytes decreases, while cadaverine dose-dependently increased this indicator. At the same time, after exposure to putrescine, the proportion of large lymphocytes and the number of vacuoles in the cytoplasm increased. Cadaverine at a concentration of 25 mmol/L significantly reduced the number of cells with signs of cytolysis. Thus, in the course of the conducted studies, it was found that cadaverine and putrescine, produced mainly by prokaryotic cells, affect both the number and cytological characteristics of immunocompetent cells.
Melatonin as a promising factor in correction of the intestinal microbiome in inflammatory bowel diseases
Authors:   South State Medical University, Osikov Michael V. , Grechishkin Maksim V. ,   South State Medical University, Shishkova Yulia S. ,   South State Medical University, Ilyinykh Marina A. ,   South State Medical University
Published: November 2023

Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The etiology and pathogenesis of IBD remain unclear, the most common hypothesis being that an abnormal immune response against the gut microbiome is triggered by environmental factors in genetically predisposed individuals. The disadvantages of first-line therapy for IBD are the occurrence of side effects in more than 30% of patients. In this regard, the development of new safe drugs that act mainly locally is relevant. The aim of the work is to analyze current data on the mechanisms of action, effects on the intestinal microbiome of melatonin in the context of possible use in IBD. Melatonin (MT) is a biologically active substance, synthesized in the body from tryptophan, and realizes its effects through MT-dependent and MT-independent receptors located in the cell membrane and nucleus. MT is involved in the regulation of circadian rhythms, has antioxidant and immunomodulatory effects. In experimental modeling of IBD and in clinical conditions, MT reduces the severity of the inflammatory process in the wall of the colon by interrupting the processes of lipid peroxidation and inactivation of free radicals, as well as by acting through specific receptors on the function of blood cells of lymphoid organs. MT in IBD leads to a qualitative and quantitative change in the intestinal microbiome, elimination of signs of dysbiosis, an increase in the number of short-chain fatty acid producers - Actinomycetota (Actinobacteria) and a decrease in the number of bacteria that increase the permeability of the intestinal barrier - Bacteroidota (Bacteroidetes). Presumably, MT has a bacteriostatic effect by binding free iron and acting on the NF-kB and STAT1 signaling pathways, which may be a factor in the correction of colon dysbiosis in IBD. Data on the effect of MT on the composition of the intestinal microbiome are a prerequisite for further preclinical studies and the possible use of melatonin in IBD in clinical practice.
ON THE POSSIBILITY OF DETERMINING THE DEGREE OF SOIL POLLUTION WITH HYDROCARBONS BASED ON ESTIMATES OF CHLOROPHYLL CONTENT IN LEAVES AND CROWNS OF PLANTS
Authors: Azizova Ayshen E.
Published: November 2023

The article analyzes the possibility of determining the degree of soil contamination with hydrocarbons by assessing the chlorophyll content in the plant. The problem of joint assessment of soil pollution based on the chlorophyll content in the leaves and crowns of plants has been formulated and solved. Formulas were obtained for calculating the total content of petroleum hydrocarbons depending on the amount of chlorophyll in the leaves and crown of the plant, as well as for calculating the unevenness of soil pollution between two given points of the soil covered with plants.
XANTHAN AS A UNIVERSAL POLYMER FOR OIL AND GAS PRODUCTION AND A PRODUCT OF BIOTECHNOLOGY
Authors: Magadova Lyubov A. , Poteshkina Kira A. , Davletshina Lucia F. , Dmitriev Yan O.
Published: November 2023

The interest in the use of xanthan biopolymer in oil and gas production processes has never lost its relevance. This fact is due to the high rheological properties of its aqueous solutions, as well as stability in the field conditions. Lately the issues of water-soluble polymers application are being reconsidered, as the issues of logistics and import substitution have become of great importance. This paper examines the main trends in the use of xanthan over the past decade, as well as the basics of its production.
Psicologia na atenção básica: cuidado aos idosos com doenças crônicas não transmissíveis
Authors: Fragassi Ana Carolina da Paz , Bonfim Camila Barreto , Martins Daniela Maria Barreto , Bernardo Kátia Jane Chaves
Published: November 2023

OBJETIVO: Este trabalho tem por objetivo compreender como os Determinantes Sociais da Saúde estão presentes nas práticas de cuidado à população idosa com hipertensão arterial sistêmica e diabetes mellitus ofertadas pelas psicólogas da Atenção Básica. MÉTODO: Foi realizada uma pesquisa descritiva e de abordagem qualitativa, a partir de entrevistas semiestruturadas, com 7 psicólogas atuantes em Unidade Básica de Saúde (UBS) e/ou Unidade de Saúde da Família (USF) de Salvador (BA), que atendem o público idoso, tendo ocorrido em plataforma digital. A análise de dados ocorreu através do método hermenêutico-dialético e teve a Psicologia Social Crítica como base teórica. RESULTADOS: Verificou-se que a atuação das psicólogas na Atenção Básica à população idosa com Hipertensão Arterial Sistêmica e Diabetes Mellitus, em sua maioria, é orientada por práticas de promoção da saúde, prevenção à doença e políticas públicas em saúde. Identificou-se, de modo geral, a compreensão dos Determinantes Sociais da Saúde como produtores de iniquidades em saúde nos relatos das psicólogas, tendo sido mapeado somente 2 psicólogas que demonstraram não compreender a categoria ‘raça’ como um Determinante Social indissociável dos demais. CONCLUSÃO: Observou-se que o campo de atuação da psicologia no contexto da Atenção Básica, guiada pela Psicologia Social Crítica e pela Saúde Coletiva, promovem contribuições teóricas para todos os campos da psicologia.
Análisis del Proceso de Integración Relacional de los Inmigrantes en España: El Factor Étnico
Authors: Cañadas-Romero Maria Aurora , Iglesias Martínez Juan , Rúa Vieites Antonio , Fernández García Mercedes
Published: November 2023

En esta investigación se analizará el papel que tienen las redes sociales en el proceso de integración relacional de la población inmigrante en España. En concreto, se estudiará como el factor étnico de la red condiciona su proceso de incorporación a los grupos primarios de la sociedad de acogida. Para llevar esto a cabo se desarrolla un indicador que nos permite conocer la concentración étnica de la red, diferenciando entre redes étnicas, mixtas y nativas. Posteriormente, aplicando un análisis de correspondencias se identifican aquellas variables que influyen en el proceso de evolución relacional de las redes sociales. Las principales conclusiones apuntan a que las redes de los inmigrantes no evolucionan de manera natural hacia redes asimiladas, sino que lo que se produce es un proceso de ampliación de la red. Así, las redes mixtas se constituyen como la forma más común de desarrollar vínculos con nativos. Además, en este caso el paso del tiempo en el país de acogida o la generación no parecen determinar el acceso a redes nativas, sino que la posesión o pertenencia a estas redes parece venir explicada por factores estructurales como el nivel educativo y la ocupación profesional.
Analysis of the Impact of Automatic Content Reflow on the Speed of Full Page Rendering
Authors:   Derzhavin Tambov State University, Tambov, 392000, Russian Federation, Zhukov S. V. , Kovaleva O. A. ,   Derzhavin Tambov State University, Tambov, 392000, Russian Federation, Kovalev S. V. ,   Derzhavin Tambov State University, Tambov, 392000, Russian Federation
Published: November 2023

Now more and more information is transmitted via the Internet, including through websites. The speed with which sites are displayed to users affects their attitude to the resource they are viewing, and therefore, the speed also affects the success of the resource itself. For example, search engines will be less likely to offer users resources with lower behavioral factors. Despite this, the display speed of many sites is low. This state of affairs harms both the end user of information and the owners of Internet resources. To fix the download speed, you can apply content reflow to optimize the html document. Manually making such edits is a rather time-consuming process. It can be accelerated by automating content reflow through special algorithms. The aim of the work is to optimize the structure of the HTML page to increase the speed of its full display by the browser. A list of services is provided that allows you to check the page loading speed. The text describes the "mirror" script, designed to create copies of web site pages, to test html content optimization algorithms. Descriptions of algorithms developed to solve the problem of low download speed are given. The article presents the results of content optimization on the example of two sites. The full page rendering speed measurement model provided by the Google PageSpeed Insights tool was used, which includes the following metrics: First Contentful Paint (FCP), Speed Index (SI), Total Blocking Time (TBT), Largest Contentful Paint (LCP), Cumulative Layout Shift (CLS). The developed algorithms for automatic reflow of html documents show their effectiveness in optimizing page loading speed according to Lighthouse 9 and 10 versions.
A Set of Products for Remote Control of Rolling Stock Characteristics
Authors:   Irkutsk State Transport University, Irkutsk, 664074, Russian Federation, Larchenko A. G.
Published: November 2023

A modern specialist in the field of maintenance and repair of rolling stock needs to constantly have access to up-to-date information about the technical condition, equipment and location of serviced units. This article analyzes the existing software products and applications that allow you to plan and manage the processes of repair work and operation. The work is devoted to the creation of products for finding up-to-date information about the technical condition of rolling stock units both on a personal computer and in an online application environment. Programs have the ability to be updated and supported, including bug fixes. The use of the proposed tools will allow a specialist in the field of logistics, maintenance and repair of rolling stock to increase the efficiency of forecasting, organization of transport processes and repair work. The algorithms of operation of each software product are formed in the work. The algorithms are presented in the form of flowcharts. The generated database is presented. Geometric parameters and wheelset numbers, dates of the last maintenance and overhaul, location were added to the presented database in accordance with the number. An array of data with photos of car was also created. The article presents a text written in the Python programming language. This language made it possible to fully implement the algorithm of the products actions. During the testing of the programs, the operation of the main functions was checked, namely, the search for parameters by the composition number. The work solved the problem of displaying photos and videos on the screen at the users request. This function will reduce the time to choose a rolling stock unit for rent and control the quality of repairs. The results of the work of programs in the environment of online applications and on a personal computer are presented in the form of drawings. When creating a software product in an online application environment, the issue of data transfer security (whitelist, password encryption, end-to-end encryption, as well as copy and forwarding protection) was resolved.
Yeni Atanmış Beden Eğitimi ve Spor Öğretmenlerinin Teknolojik Pedagojik Alan Bilgisinin İncelenmesi
Authors: GÖRMÜŞ Celal , SEMİZ Kıvanç
Published: November 2023

Bu çalışmanın amacı yeni atanmış beden eğitimi ve spor öğretmenlerinin teknolojik pedagojik alan bilgisinin incelenmesidir. Çalışmaya 2022-23 öğretim yılında yeni atanmış 162 beden eğitimi ve spor öğretmeni katılmıştır. Karma yöntem olarak tasarlanan araştırmanın nicel kısmında Semiz ve İnce tarafından 2012 yılında Türkçeye uyarlanan Teknolojik Pedagojik Alan Bilgisi Ölçeği 156 kişiye uygulanmıştır. SPSS 25 kullanılarak veri analizi gerçekleştirilmiştir. Verilerin normal dağılım göstermesi ile parametrik testlerden bağımsız t testi kullanılmıştır. Nitel kısımda ise 6 katılımcı ile yapılandırılmış görüşme sorularıyla veriler toplanarak görüşme kayıtlarının çözümlemesi yapılmış ve elde edilen sonuçlar MAXQDA programı ile tematik içerik analizi yapılarak kategorize edilmiştir. Toplam üç ana başlık altında bulgular raporlanmıştır. Bunlar sırasıyla; Hizmet öncesi deneyimler, Hizmet içi deneyimler ve Mesleki Öğrenme olarak sıralanmaktadır. Bu çalışmada mesleğe yeni başlamış beden eğitimi ve spor öğretmenlerinin teknolojik pedagojik alan bilgisi belli başlı konularda incelenip raporlanmıştır. Teknolojinin rolü konusunda öğretmenlerin; pozitif bir tutuma sahip olduğu, teknolojiyi meslek hayatında kendilerini geliştirmek adına fırsat olarak gördükleri raporlanmıştır. Beden eğitimi ve spor öğretmenlerinin TPAB düzeyleri cinsiyet kavramına ilişkin erkeklerin lehine farklılaşırken; yaşa göre farklılık bulunmadığı tespit edilmiştir. Karşılaşılan sınırlılıklara öneriler kısmında yer verilmiştir.
Hereditary cancer syndromes with increased risk of renal cancer
Authors: Mikhaylenko D. S. , Gorban N. A. , Zaletaev D. V.
Published: November 2023

Renal cancer (RC) is one of the three most common diseases in oncologic urology. Its accurate diagnosis and prognosis remain difficult and important problems. Some cases of RC are associated with hereditary cancer syndromes and are caused by germline mutations. This review describes monogenic forms of hereditary RC (von Hippel–Lindau syndrome, Birt–Hogg– Dubé syndrome, hereditary leiomyomatosis and renal cell cancer, hereditary papillary renal carcinoma, BAP1 tumor predisposition syndrome) and diseases with several candidate genes (SDH-mutated tumors, tuberous sclerosis complex). Additionally, the review discusses the increased risk of RC in patients with frequent hereditary cancer syndromes predisposing to the development of a wide range of tumor types: Lynch and Li-Fraumeni syndromes. RC in combination with other carcinomas can develop in patients carrying pathogenic mutations in the candidate genes of different hereditary cancer syndromes –  multi-locus inherited  neoplasia  allele syndrome (MINAS)  –  which is especially important  due to the growing role of high-throughput sequencing in practical oncologic genetics. Additionally, guidelines on modern laboratory genetic diagnostics and active surveillance are presented for each syndrome.
Clinical use of high dose-rate brachytherapy in treatment of patients with localized prostate cancer and infravesical obstruction
Authors: Yagudaev D. M. , Martov A. G. , Ergakov D. V. , Yagudaev D. D. , Kadyrov Z. A.
Published: November 2023

Background. High dose-rate brachytherapy is a new method of interstitial radiation therapy for treatment of localized prostate cancer. The difference from low dose therapy is temporary implantation of radiation sources with targeted high dose-rate irradiation of the affected organ.

Aim. To evaluate 3-year effectiveness and safety of high dose-rate brachytherapy in patients with infravesical obstruction. Materials and methods. Between January of 2017 and December of 2019 at the Central Clinical Hospital “RZD-medicine”, 49 patients  (mean age 67.8 ± 7.5 years) with verified prostate  cancer diagnosis underwent high dose-rate brachytherapy in the regimen of 2 sessions of 15 Gy with 192Ir source. The inclusion criteria were disease stage ≤сТ2с, Gleason score ≤7. Patients were divided into 2 groups: 1st – patients with incidental prostate cancer (n = 21) who previously (more than 6 months ago, mean time 9.4 ± 2.4 months) underwent transurethral prostatectomy; 2nd – patients with verified prostate cancer (mean prostate volume 56 cm3) and obstructive symptoms without previous transurethral prostatectomy (n = 28).

Results. In both groups, no intraoperative complications were observed. In 6 (28 %) patients of the 1st group and 2 patients of the 2nd group, grade II genitourinary toxicity in the form of moderate dysuria and nocturia was observed. Acute gastrointestinal  toxicity was observed in 3 (14 %) patients of the 1st group, in the 2nd group such complications were absent. In the 2nd group during the postoperative period after the 2nd session, 4 patients (14 %) experienced acute urinary retention requiring cystostomy.

Conclusion. High dose-rate brachytherapy is a safe and effective radical treatment method for patients with localized prostate cancer with obstructive symptoms who have contraindications for surgical treatment.