bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of the evolutionary transition/transversion bias of birds and mammals by the CYTB gene
Authors: Mezhzherin S.V. , Morozov-Leonov S.Yu.
Published: April 2024

Differences in the nature of the transition/transversion bias of birds and mammals, as well as families with small and large body-sized species, are proven by the example of the CYTB gene. It was that for birds compared to mammals, as well as in families of small birds and mammals compared to larger ones, the frequency of transversions is significantly higher and the frequency of transitions is lower. This leads to a decrease in the transition/transversion bias and a decrease in the rate of its evolutionary compensation. The possible cause of this phenomenon is the greater intensity of individual metabolism and the resulting increase in mutation rates in birds and small species. Exceptions are extremely small species that are characterized by a state of hypothermia. The high level of metabolism and mutability explains the richness of bird species, as well as the highest activity of speciation in small organisms. In addition, the transition/trans- version bias should be considered as a reliable integral indicator of individual metabolic intensity at the family level.
Impact of «Rural» Behavioral Strategies of the Population of Ukraine on Quality of Life in Times of War
Authors: KOHATKO YURII , POLІAKOVA SVITLANA
Published: April 2024

The purpose of the article is to analyse and understand how «rural» behavioural aspects of the Ukrainian population influence the perception and adaptation to the conditions of armed conflict. The novelty of the study lies in the analysis of those rural behavioural aspects that are common to the entire population and may impact adaptation strategies and the improvement of quality of life during military events. In the context of modern conflicts and war scenarios, the study of population behaviour and its impact on the resilience of quality of life becomes particularly significant. Military conflicts not only threaten the safety and stability of society but also sharply increase the importance of understanding population behavioural aspects in the conditions of armed conflict and their impact on the quality of life. The examination of population behaviour during an extreme period of armed conflict potentially provides answers to how effectively the Ukrainian population can adapt to economic difficulties and overcome them. For the investigation of the impact of «rural» behavioural aspects on the quality of life of the population in Ukraine, a combination of specialized and general scientific methods was employed. These include the monographic method, bibliometrics, and content analysis. Additionally, forecasting and modelling methods were utilized to predict the impact of fullscale military actions on poverty, a key indicator of quality of life. After the conducted research, it can be noted that in the conditions of a full-scale invasion by Russian forces, the «rural» behavioural characteristics of Ukrainians exhibit numerous advantages, arising from the close interaction between rural and urban existence. It is demonstrated that a potentially significant portion of the country’s population, particularly those of rural origin, possesses skills in land management. The presence of relatives in villages and small towns, who have large living spaces and substantial land plots, enabled the acceptance of many forcibly displaced individuals during the war. The study confirms that behavioural traits such as the tradition of stockpiling food supplies, maintaining habitable housing conditions in rural areas, and the existence of close familial and social ties have significantly mitigated the impact of the war on the population.
Usage of Big Data for Information Support of the Labor Market
Authors: ROZBYTSKYI MYKHAILO
Published: April 2024

The challenges of collecting current labor market data amidst global changes and geopolitical fluctuations increasingly necessitate new approaches and alternative methods of data collection and analysis. This highlights the relevance of research aimed at developing and adapting labor market information provision methods to contemporary challenges. A promising approach in this context is the use of Big Data for labor market assessment, which involves collecting information from sources such as online job search and vacancy portals. This method allows for a deeper analysis of market trends and provides a more accurate and timely assessment of labor market needs and opportunities. The aim of this article is to discuss approaches to developing labor market information systems using Big Data, particularly online data from job vacancy websites. It examines the use of Big Data in labor market analysis based on a database containing over four million job vacancies posted on Ukrainian job search portals over the last five years, provided by the European Training Foundation (ETF). The effectiveness of these approaches in facilitating job search for all interested parties is evaluated, particularly through providing insights into the dynamics of supply and demand in the labor market based on data from these portals. The opportunities and limitations of using Big Data in this context are analyzed, including their impact on employment policy development and labor market planning. The potential benefits of Big Data in providing deeper and more accurate market condition analyses are outlined, along with technical aspects and challenges associated with their processing and interpretation. The article examines methodological approaches to data collection and analytical processing in the context of accelerated transformations, volatility, and limited access to traditional information resources. The scientific novelty of the article lies in the substantiation of the feasibility and appropriateness of using open data from online job portals for labor market information provision under current conditions. In conducting the research, methods of analysis, synthesis, and generalization were applied to identify the main contemporary issues of labor market information provision in Ukraine. The effectiveness of data collection methods based on web scraping and parsing techniques was evaluated, as well as the use of the integrated Snowflake platform to identify key trends and patterns in the labor market. The conclusions summarize the main points and substantiate directions for further research, highlighting the significance of Big Data in developing employment strategies and optimizing the labor market.
COOPERATIVE MODELS OF DOING BUSINESS AND THEIR ROLE IN FARMING COMMUNITY DEVELOPMENT
Authors: Atanassova-Kalaydzhieva T.
Published: April 2024

A collective business model with a specific character, distinguishing it from personal and capital companies is the cooperative. The cooperative model has been refined over the years and has become one of the widespread models for managing factors of production and providing services to its members in almost all economic sectors and countries around the world. A cooperative is a voluntary association of natural persons who, through mutual assistance and cooperation under equal responsibility and rights, transfer part of their functions to a common enterprise. Co-operation has proven to be a successful business model for building joint production facilities for processing the primary plant and animal products of farmers, thus creating additional income for them. Based on the broad scope of the subject, I limit the purpose of development to highlight the advantages of the cooperative model for doing business in association (unification) of farmers on the example of several European countries. A main conclusion of the study is that cooperatives play a crucial role in the prosperity and socio-economic development of the farming community they serve and the rural areas in which they are located.
THE COOPERATION OF PRIVATE VETERINARY DOCTORS - POSSIBLE SOLUTIONS AND PERSPECTIVES
Authors: Kostadinova N. , Aleksiev G.
Published: April 2024

The veterinary medical service in our country has traditions and a history of more than a century. In the twenties of the last century, the geographical position of Bulgaria was assessed, as a potential corridor for the invasion of epizootics and toxic infections from Asia to Europe, from active outbreaks and epizootic diseases (in animals) and zoonoses (in animals and humans) in Asia and the Middle East to Central and Western Europe. This is the reason why the Bulgarian veterinary medical service is expected to organize active anti-epizootic measures, to create a "shield" that would protect both the country and Europe from animal and human infections.
The aim of the current paper is to study the possibility of cooperation of privately practicing veterinarians in the country and the benefits of this cooperation in the performance of their functions.
The methods that will be used to achieve this goal are analysis and synthesis, induction and deduction, monographic, etc.
The expectations of this research are that the cooperation of veterinarians is a prerequisite for better performance of veterinary medical measures to protect the health of animals and people.
IDENTIFICATION OF OPPORTUNITIES FOR DIGITALIZATION OF MANAGEMENT PROCESSES IN SUNFLOWER PRODUCTION
Authors: Nencheva-Ivanova I.
Published: April 2024

The current complex geopolitical and economic situation leads to increased competitive pressure on producers of agrarian products, especially in crop production. The optimization of management processes can help to improve the profitability of crop production and, accordingly, the competitiveness of the offered products. The application of digital models for this optimization will continue to increase in importance in the future.
The aim of the present study is to evaluate the possibilities of digitization of management processes in sunflower production. In order to achieve the goal, it is necessary to solve the following tasks: to assess the level of competitiveness of the Bulgarian sunflower production; to analyze the factors determining the level of competitiveness; to analyze the levels of digitalization of management processes in sunflower production and offer future pathways for development.
El epígrafe «CIHM» 3, 25 (Corcos del Valle, Valladolid) en el «Itinerario» de Juan Arce de Otálora: los manuscritos 7879 y 18227 de la Biblioteca Nacional de España
Authors: Lorenzo-Fernández Álvaro , Moreno-Benito Arturo
Published: April 2024

Se presentan nuevos datos acerca de una inscripción medieval procedente de Corcos del Valle (Valladolid) (CIHM 3, 25) en dos manuscritos de la Biblioteca Nacional de España (Ms. 18227 y Ms. 7879) que contienen el Itinerario «perdido» de Juan Arce de Otálora. Asimismo, se trata de los testimonios escritos más antiguos que se conocen sobre este epígrafe que, además, presentan una nueva lectura. Se abre, por tanto, la posibilidad de aportar nuevos datos sobre el contenido de la inscripción, así como del contexto y las circunstancias de su elaboración.
INOVAÇÃO FRUGAL NA EDUCAÇÃO: UMA PERSPECTIVA PARA AMÉRICA LATINA
Authors: Reyes Stephanie Torres , Romeiro Filho Eduardo , Avelar Ewerton Alex
Published: April 2024

A Inovação Frugal representa uma estratégia voltada para o atendimento a demandas sociais por meio de soluções que enfatizam a sustentabilidade, adequação e uso consciente de recursos, tornando-a particularmente adequada para países em desenvolvimento. A pesquisa quantitativa e exploratória apresentada neste artigo visou identificar e analisar as abordagens teórico-metodológicas que têm o potencial de guiar o ensino e a difusão da Inovação Frugal, considerando a perspectiva dos participantes da Red Latinoamericana de Innovación Frugal (RELIF). Os dados foram obtidos mediante um questionário online aplicado a membros da RELIF e, após a coleta e o tratamento dos dados, foram aplicadas como técnicas de análise: estatística descritiva, teste de Wilcoxon-Mann-Whitney e estatística do Qui-quadrado. Os resultados corroboraram tópicos teóricos mapeados na literatura, salientando o caráter inter e transdisciplinar da Inovação Frugal. O estudo revelou as potencialidades dessa inovação como estratégia para a formulação e a implementação de processos de ensino e aprendizagem que visam disseminar o desenvolvimento sustentável em Instituições de Ensino Superior da América Latina. O trabalho também contribuiu com a prática relativa à apropriação do valor frugal em dinâmicas pedagógicas universitárias, especialmente, para docentes e pesquisadores latino-americanos.
A Hipertelevisão no Cenário Mediático Brasileiro: Uma Análise das Estratégias Adotadas Pela Plataforma de Streaming Globoplay
Authors: Santos Neto Valdemir
Published: April 2024

Este artigo visa examinar como a televisão brasileira tem respondido às tendências tecnológicas no contexto da convergência mediática, com foco específico na plataforma de streaming do Grupo Globo, o maior conglomerado de média da América Latina, conhecida como Globoplay. O argumento central deste artigo gira em torno das várias formas de engajamento empregues pela organização enquanto procura adaptar-se ao cenário de constante mudança dos média. Utilizando o método de estudo de caso (Yin, 2015), esta pesquisa correlaciona o quadro teórico com três pontos centrais destinados a discutir as noções de engajamento na era da convergência dos média como base para as relações da televisão com os seus anunciantes, a criação de produtos e projetos audiovisuais e, sobretudo, a sua relação com a audiência. A análise destaca o uso de técnicas como inteligência artificial e aprendizagem automática, que ajudam a plataforma a remodelar as suas estratégias e processos de tomada de decisão. À luz dos resultados e discussão subsequentes, pode-se inferir que o objetivo principal dessas iniciativas consiste em adaptar-se ao contexto hipertelevisivo e ampliar o modo como o Grupo Globo se relaciona tanto com o seu público como com os seus anunciantes.
Improving walking via real-time visual feedback after stroke in treadmill training (RE-VISIT): a protocol for randomized controlled trial
Authors: Janakiraman Balamurugan , Ranganathan Parthasarathy , Ravichandran Hariharasudhan , Shetty Kshama Susheel
Published: April 2024

BACKGROUND: After a stroke, most patients often suffer reduced walking ability and balance. Restoring walking ability and improving balance are major goals of stroke rehabilitation. Treadmills are often used in clinical setups to achieve these goals. Adding dimensions to the visual feedback in addition to the mirror for real-time frontal view is proven to enhance the gait. It is, therefore, important to design additional real-time visual feedback in treadmill training, in particular for the sagittal view involved side. OBJECTIVE: The objective of this study is to test if the real-time sagittal visual feedback during treadmill training is superior to the conventional mirror feedback treadmill training program of equivalent intensity in improving walking speed and balance after stroke. METHODS/DESIGN: The RE-VISIT trial (Real-time Visual feedback after Stroke in Treadmill training) is registered in the Clinical Trial Registry of India (CTRI/2023/10/058299). In this two-arm randomized control trial, which will be a single-blinded study, 42 eligible stroke survivors undergoing rehabilitation will be randomly allocated (1:1 ratio) to either real-time visual sagittal feedback along with front mirror (experimental) group or only front mirror treadmill training (control) group, all the participants will receive 15 sessions of treadmill training for up to 15 min at a safe self-selected speed over 5-6 weeks. The RE-VISIT (experimental) group will receive real-time, visual sagittal view feedback of the involved lower limb trajectory along with the routine front mirror view during treadmill training and will be asked to modify their gait pattern. The control group will receive treadmill walking training only with the routine front mirror view feedback. Clinical and gait assessments will be conducted at the baseline, immediately following the final session of training, and at the 9th week during follow-up. The outcome measures of interest are walking speed (primary) and balance (secondary), which will be measured prior to baseline, post 15 sessions of training, and at the 9th week following training. DISCUSSION: This REVISIT trial will provide insight and contribute to the existing innovation and modifications of incorporating real-time visual feedback during treadmill training in post-stroke gait rehabilitation. The findings will help the better designing of a gait rehabilitation program with a treadmill for post-stroke subjects to improve walking speed, and balance for those who have greater difficulties in community ambulation. We anticipate that those in the REVISIT training will demonstrate improved walking ability.
Fungal contamination of medicinal cannabis: A bibliometric evaluation, trends, and future perspectives
Authors: Alzate Paola , Clara Shiroma Maria , Castro-Rios Katherin
Published: April 2024

Fungal contamination is an important problem in cannabis and medical cannabis production, as fungi can produce toxic compounds or reduce the quality and safety of the product. The aim of this study was to perform a bibliometric evaluation related to fungal contamination in cannabis, analyzing current trends in this field and providing future perspectives for research. For this purpose, an exhaustive search was carried out in the scientific literature in electronic databases such as Scopus and Web of Science (WOS), covering the period from 2000 to 2023. The results obtained were processed through bibliometrics and network analysis, using tools such as RStudio and Bibliometrix software. The results revealed that the main themes associated with fungal contamination in cannabis are focused on: diseases related to fungal contamination of the plant, use of fungi as an alternative biological control in cannabis cultivation, metabolites associated with cannabis and their potential in fungal control, as well as fungal diversity in cannabis cultivation and postharvest and the risk to consumer health. Finally, future research areas are proposed to address the challenge of fungal contamination in medicinal cannabis production, covering topics such as pest control, contamination, genetic resistance, active compounds, analysis methods, and the impact of fungi on cannabis.
ESTRATÉGIAS DE PLANEJAMENTO EDUCACIONAL: CURADORIA FORMATIVA EM GESTÃO ESCOLAR NO CURSO DE LICENCIATURA EM PEDAGOGIA
Authors: Lefone Fátima Ramalho , Silva Renan Antônio da
Published: April 2024

O artigo apresenta o contexto histórico do Curso de Licenciatura em Pedagogia e seus impactos na formação inicial do Gestor Escolar, em especial aos que atuarão em escolas públicas. Enfatiza-se  ao longo do processo histórico, como os aspectos formativos no Curso de Licenciatura em Pedagogia suscitam lacunas  à formação específica  para a atuação de futuros Gestores Escolares. Objetiva-se a partir da revisão de literatura apresentar aportes teóricos pertinentes que revestem a referida formação profissional e identitária do Gestor Escolar, além de quadros comparativos  com aspectos legais e suas alterações  ao longo da  história. Em consequência da pesquisa teórica desenvolveu-se em locus com alunos do Curso de Pedagogia de uma Instituição de Ensino Superior privada, situada na região central de São Paulo, ações específicas utilizando metodologias ativas e colaborativas, cuja temática resultou na  elaboração e vivências relativas a  construção do Projeto Político Pedagógico,  com ênfase nos aspectos  transdisciplinares e foco em estratégias de planejamento educacional como forma de  curadoria formativa em Gestão Escolar. Verifica-se que o redimensionamento do currículo e as contribuições epistemológicas  atenuam as lacunas na formação inicial do Gestor Escolar. O corpus da pesquisa resultam da coleta de dados que colaboram na composição do texto com evidências da realidade. Os resultados indicam que a participação dos alunos  em ações   formativas dessa natureza incide qualitativamente na apropriação de concepções específicas e nos aspectos teóricos, metodológicos e práticos para o exercício  da Gestão Escolar.
Tendência das taxas de internação por complicações de Diabetes Mellitus na população do município de Macaé, Rio de Janeiro, no período de 2011 a 2021
Authors: De Melo Valeriote Nascimento Anna Clara , Ribeiro Sgambato Michele , Dias Fernandez Verônica , Lopes do Nascimento Thayná , De Souza Azeredo Laueny , Martins Maltez Júlia , Nolasco Fernandes Santos da Silva Lucas , Santa Cruz Coelho Karla
Published: April 2024

Objetivo: Avaliar a tendência das taxas de internação por complicações de Diabetes Mellitus na população de Macaé-Rio de Janeiro, 2011-2021. Métodos: Estudo ecológico de séries temporais das taxas de internação por complicações de Diabetes Mellitus na população de Macaé em 2011-2021. Os dados foram obtidos através do Sistema de Informações Hospitalares da plataforma do Datasus. Os modelos de regressão Joinpoint foram utilizados para estimar a tendência da taxa de internação. Resultados: A taxa de internação por complicações de Diabetes Mellitus por ano, de modo geral, foi maior no ano de 2016 e menor taxa no ano de 2020. Entre 2017 e 2021, verificou-se uma tendência significativa decrescente de -19,71% (Intervalo de Confiança -36,71; -9,73) das taxas de internação por complicações de Diabetes Mellitus. Conclusão: Houve uma redução acentuada nas taxas durante a pandemia, o que pode ser devido à subnotificação no registro de internações.
 
Palavras-chave: Diabetes Mellitus; Internações; Doenças Crônicas; Estudos de Séries Temporais.
L'effet de l'incorporation des sédiments calcinés et de la perlite comme remplacement partiel du ciment sur le comportement des mortiers
Authors: Achour Mokhtar , Belas Nadia , Sadok Rachid Hadj
Published: April 2024

L'accumulation de sédiments dans de nombreux barrages construits en Algérie pose un problème préoccupant qui nécessite une attention et une action immédiate de la part des autorités et des gestionnaires de l'Agence Nationale des Barrages et des Transferts (ANBT). De plus, diverses recherches sur les sédiments ont révélé que le fait de les soumettre à un traitement thermique (calcination) permet de les utiliser dans la production de matériaux cimentaires comme substitut partiel au ciment. Additionnés à la perlite, une pouzzolane naturelle, de nombreux avantages peuvent être obtenus, notamment une consommation de ciment réduite, une génération de chaleur minimisée, une maniabilité améliorée, une perméabilité réduite et une résistance accrue. Dans cette étude, l'objectif est d'explorer le potentiel d'utilisation des Les sédiments extraits du barrage Chorfa II ainsi que la perlite provenant de Hammam Boughrara (tous deux situés dans l’ouest algérien) dans le mortier, comme substituts partiels au ciment. Une analyse des sédiments calcinés et de la perlite a révélé la faisabilité d'un remplacement partiel du ciment. Les recherches se sont principalement concentrées sur l'évaluation des propriétés des mortiers à l’état frais et durci.
不同品种怀地黄小分子糖类差异性分析
Authors: 赵婉琳  , 宋梦娇  , 蔡奕宁  , 刘淼  , 文春南  , 阮元  , 李晓  , 王丽  , 麻兵继
Published: April 2024

对不同品种怀地黄小分子糖类含量进行比较，旨在探究其小分子糖类含量的差异以及为制定怀地黄的产品质量标准提供科学依据。采用高效液相示差折光检测器对不同品种怀地黄的果糖、葡萄糖、蔗糖、棉子糖、水苏糖进行含量检测。鲜地黄小分子糖类物质总含量：北京脱毒3号 > 怀丰 > 金九 > 怀中1号 > 北京3号。生地黄小分子糖类物质总含量：金九 > 怀丰 > 北京脱毒3号 > 北京3号 > 怀中1号。五个品种地黄小分子糖类物质中水苏糖的含量均是最高。鲜地黄中北京脱毒3号小分子糖类物质总含量最高，生地黄中金九小分子糖类物质总含量最高。品种不同，怀地黄小分子糖类含量有明显差异。
Geological structure of Quaternary sediments in the lower Pechora river valley
Authors: Andreicheva Ludmila
Published: April 2024

The geological structure of Neopleistocene deposits was specified along a 19-kilometer section of the right bank of the lower Pechora between the villages of Garevo and Sergeevo-Shchelya. The presence of three glacial and two interglacial horizons was revealed in coastal outcrops, and the material composition of the composing sediments was studied. The formation of the most ancient moraine horizon was associated with Fennoscandinavia and occurred in the early Quaternary Pomusov (Oka) time. The Pomusov moraine was overlain by Chirva (Likhvin) interglacial alluvial and lacustrine sediments. In the Middle Neopleistocene glacial complex, two morainic strata of different ages were distinguished: Pechora (Dnieper) and Vychegda (Moscovian), separated by a pack of predominantly coastal-marine littoral sediments, and alluvial and lacustrine sediments, the age of which was determined as Rodionov (Shklov) by the palynological method. Differences in the lithological composition of moraines confirmed a double glaciation of the European North-East of Russia in the Middle Neopleistocene.
Groundwater of Middle Jurassic deposits of the southern regions of the Komi Republic
Authors: Koksharova Yu. , Amosova O
Published: April 2024

The features of the chemical composition of fresh groundwater of the Middle Jurassic aquifer complex in the southern regions of the Komi Republic, which is the main source of drinking water supply, are shown. Groundwater is mainly confined to the sole, composed of quartz sands, of the Sysol formation of the Middle Jurassic (J2ss) and is distributed at depths from 13.7 to 119 m. The waters are confined to the zone of active water exchange, to the areas of infiltration of atmospheric precipitation in the territory with a humid climate. The waters have a bicarbonate-calcium composition, a near-neutral medium, mineralization up to 0.58 g/dm3 and after preliminary water treatment (degreasing, demanganation) can be used for drinking purposes. Based on the conducted geochemical studies and statistical data processing, the main patterns of the distribution of macro- and micro–components in the groundwater of the Middle Jurassic sediments have been established, the leading processes of formation of the main components of the chemical composition of groundwater — oxidation, hydrolysis, cation exchange and sulfate reduction — have been identified.
Essential elements of a city offer addressed to digital nomads: The perspective of territorial marketing
Authors: Sztuk Aleksandra
Published: April 2024

The digital nomad lifestyle has become one of the fastest-growing trends in the labor market in recent years. Digital nomads, people settling in a city as its residents for several months before changing their location again, are active consumers of the city’s offer, which profits the host territorial unit. This specific group of customers requires designing a separate communication of the city offer, increasing the probability of choosing a given city as the next destination. The article aims to identify the significant elements of the city’s offer from the perspective of digital nomads. These data were collected based on the literature (scoping review method) and then summarized. The author identified key aspects related to the expectations of nomads towards the destination and the barriers encountered during the stay.
Medication use review as a service for pharmaceutical care: Conditions for implementation in pharmacy practice
Authors: Żak Konrad
Published: April 2024

Pharmaceutical care is an aggregated pharmaceutical service based on an innovative approach towards the patient’s pharmacotherapy process. It was introduced into the Polish pharmaceutical law system in 2008, but it was not until the end of 2020 that the list of activities included in this innovative health service was clarified. The delayed initiation of pharmaceutical care means that implementation procedures are lacking, making it difficult to fully implement it into pharmacy practice. The initiating service for pharmaceutical care in pharmacy practice is the medication use review (MUR), which, combined with the pharmacotherapy assessment, has the task of detecting and solving patients’ drug-related problems and thus ensuring safety in the pharmacotherapy process. Such important objectives for medication use review face organisational barriers that make its effective implementation difficult and practically impossible, limiting the scope of pharmaceutical care to the consultative aspect in practice. The aim of the article is to present the implementation conditions of medication use reviews in Polish pharmacy practice, which helped to identify the conditions for effective implementation of pharmaceutical care. Achieving the research objectives requires the use of a variety of research methods. To identify the conditions for effective implementation of medication use reviews, the method of analysis of legal acts was used. Apart from that, the analysis of literature and the method of examination of documents were also implemented, which made it possible to determine whether the Polish pharmaceutical law system creates conditions for effective provision of this service in pharmacy practice. The method of observation (the mystery shopper) was also used to indicate the territorial (subjective scope) scope of the provision of medication use review and to identify barriers to their implementation in Polish organisational and legal realities. All the methods applied made it possible to determine to what extent pharmacist shortages in the pharmacy limit the implementation process. The results of the study were subjected to statistical analysis.
Which companies among the SMEs operate in accordance with the Sustainable Development Goals
Authors: Węglarz Magdalena , Ropuszyńska-Surma Edyta , Zimmer Joanna
Published: April 2024

The purpose of the article is to identify the factors that have a significant impact on the decision of SMEs to operate in accordance with the Sustainable Development Goals (SDGs). The identification was made on the basis of data collected in December 2022 during a survey of a sample of 303 SMEs from all over Poland. In order to identify the above-mentioned factors, the following were analyzed: type of business, industry to which the primary economic activity of the surveyed company is assigned, age of the company, type of ownership, scope of activity, organizational and legal form, number of employees, average annual net income. Correlation tests confirmed the hypotheses of the relationship between the number of employees and average annual net income and operation in accordance with the SDGs. Further verification of the relationship, performed using a logit model, confirmed that average annual net income and industry are significant variables. There is a relationship between these variables and acting in accordance with the SDGs. The chance of making a decision by a company about operating in accordance with the SDGs increases as the average annual net income increases. The probability of operating in accordance with the SDGs is higher if the company operates in the following industries, i.a.: real estate activities, transportation, financial and insurance, construction, agriculture.
Using digital tools in the context of female dominance in the real estate market
Authors: Oklander Tatyana , Pandas Anastasiia
Published: April 2024

For society, women’s work is an important reserve necessary for the effective development of production. Negative trends related to female employment have a detrimental effect on the country’s demographic situation, as well as on social relations. Statistics show that it is women who experience the most problems in terms of career growth and professional development. The volume of job offers for women is characterized by a much narrower professional range, and the average salary level is lower. In addition, a woman’s chances of losing her job are always higher than those of men. However, the digital economy provides new employment opportunities for women. Working in real estate combined with digital tools increases female employment and equalizes income levels between men and women. The purpose of the article is to study the state of use of digital tools in the field of real estate, as an important component of increasing the efficiency of the work of real estate agency personnel.
DETECÇÃO DE TENDÊNCIAS NA ESTAÇÃO CHUVOSA DO ESTADO DO TOCANTINS
Authors: Cirqueira dos Santos Vinicius , Araújo e Silva Roberta , Figueiredo Maciel Girlene
Published: April 2024

A precipitação é a principal variável meteorológica no ciclo hidrológico, sendo que a caracterização do seu comportamento fundamental para gestão eficiente dos recursos hídricos. Diante desse contexto, o objetivo do presente estudo é investigar a ocorrência de possíveis tendências anuais nos dias de início e fim, duração e acumulado de precipitação, a partir de testes estatísticos, na estação chuvosa do estado do Tocantins. A análise de tendência foi obtida a partir de três testes estatísticos não-paramétricos (teste de Mann-Kendall, método de Sen’s e teste de Pettitt).Os resultados indicaram que, para os seis municípios analisados, na maioria das cidades a estação chuvosa está iniciando mais tarde, em três cidades a EC está finalizando mais tarde (não se inserindo nesse cenário Palmas, a capital do estado, e Peixe, na qual a EC está finalizando 0,1 dias mais cedo por ano), em quatro cidades a EC está durando menos e igualmente nas quatro cidades a precipitação total acumulada durante a EC está diminuindo. As tendências anuais encontradas nesse estudo corroboram com resultados de outras pesquisas para o bioma cerrado, evidenciando mudanças no comportamento da estação chuvosa do Tocantins, possivelmente – como apontado por outros trabalhos – ocasionadas por mudanças no uso e ocupação do solo.
LIGNINA COMO AGENTE DE REFORÇO EM PAINÉIS PRODUZIDOS COM Eucalyptus spp. E CASCA DE Caryocar brasiliense (PEQUI)
Authors: Carvalho Vieira Guilherme Henrique , Pereira Eufrazio de Moraes Thatiele , Ferreira Saraiva Karolayne , Marchesan Raquel
Published: April 2024

A pesquisa buscou avaliar a influência da casca do pequi em painéis aglomerados de Eucalyptus spp., usando acetato de polivinila (PVA) como adesivos e lignina e parafina como aditivos. O objetivo foi reforçar a resistência e higroscopicidade dos painéis, visando reaproveitar os resíduos da colheita do pequi. Os painéis foram produzidos com 50% de casca de pequi, 50% de madeira de Eucalyptus spp. e 300g de adesivo PVA. Foram testados três tratamentos: sem aditivos, com lignina e com parafina. Testes para propriedades físicas e mecânicas foram realizados, incluindo densidade, inchamento, absorção, resistência mecânica e isolamento acústico. Os resultados indicaram que a lignina foi o aditivo mais eficaz, demonstrando um alto potencial na produção dos painéis aglomerados com casca de pequi.
ASSOCIAÇÃO ENTRE ATIVIDADE FÍSICA E PERCEPÇÃO SUBJETIVA DE ESTRESSE EM ESTUDANTES UNIVERSITÁRIOS EM PERÍODO PANDÊMICO: 24H-MESYN STUDY
Authors: Alves dos Santos Evanilson , Marinho Franco Alaiana , Nascimento Ferreira Marcus Vinicius
Published: April 2024

Tema Geral: Ciências Biológicas e da Saúde Objetivo: Testar a associação entre atividade física e estresse subjetivo em universitários durante a pandemia de COVID-19. Métodos: Trata-se de um estudo transversal que avaliou 195 estudantes universitários (68,7% do sexo feminino; 44,6% com idade entre 21 e 25 anos; 65,8% do curso de ciências da saúde; 24,5% matriculados no 1º ao 3ºsemestre) de 17 a 52 anos. Os dados foram coletados em 2021 na cidade de Imperatriz, MA. Coletamos dados online usando a Perceived Stress Scale (14 itens) e o International Physical Activity Questionnaire (versão curta, 8 itens). Avaliamos escores de dimensões de estresse positivo e negativo como desfechos (representando autoeficácia percebida e desamparo, respectivamente), enquanto caminhada e atividade física moderada a vigorosa foram as variáveis independentes/exposições (em minutos/dia). Os potenciais confusões foram sexo biológico; idade; etnia; escolaridade materna; curso de graduação (em ciências da saúde ou outra), turno (matutino, vespertino, noturno ou integral), horário (≤ 3º ou > 3º semestre), número de turmas matriculadas e horas de estudo por dia. Avaliamos as associações usando modelos de regressão linear multinível. Resultados: Ao ajustar os modelos para sexo biológico, idade, etnia e tempo de graduação, observamos que níveis mais altos de caminhada (β = 0,02 [IC 95% 0,001 a 0,03]) foram associados a pontuações mais altas na dimensão positiva do estresse percebido. Conclusão: A caminhada associou-se a dimensão positiva do estresse percebido em universitários em período pandêmico.

Palavras-chave: Caminhada; Estresse; Estudantes.
CARACTERIZAÇÃO NUTRICIONAL E TECNOLÓGICA DA FARINHA DE INAJÁ PARA APLICAÇÃO EM PRODUTOS ALIMENTÍCIOS
Authors: Nunes Schons Sara Maria , Freitas Pires Caroline Roberta , Souza Pereira Anielli
Published: April 2024

A Maximiliana maripa (Aubl.) Drude é uma palmeira encontrada em toda a Amazônia e áreas de Cerrado. O inajá possui uma casca rígida e fibrosa, com polpa de cor amarelo vistosa e amêndoas que são aproveitadas pelo alto potencial oleífero. A polpa do inajá se mostra como uma excelente matéria-prima para produção de alimentos funcionais, com elevada capacidade antioxidante. Como fonte para a produção de alimentos, a secagem dos frutos surge como uma alternativa para reduzir as perdas pós-colheita. O objetivo desta pesquisa foi desenvolver e caracterizar a farinha obtida da polpa do fruto inajá para incorporação em produtos alimentícios. Foi realizada a descrição do fluxograma de obtenção da farinha da polpa de inajá e prosseguiu-se para as análises físico-químicas e tecnológicas da formulação, assim como determinação da capacidade antioxidante. O inajá apresentou maior composição de carboidratos e lipídios. Nas análises tecnológicas foi observado um baixo percentual de solubilidade, mas uma alta capacidade de reidratação. A farinha de inajá apresentou um alto percentual de sequestro de radicais livres e alto teor de compostos fenólicos. Deste modo, a exploração de frutos do cerrado para o desenvolvimento de produtos alimentícios consiste em uma forma conveniente para o desenvolvimento sustentável.
Computational Pharmaceutics: A Comprehensive Review of Past Achievements, Present Applications, and Future Challenges
Authors: Chaudhari Yogesh , Chaudhari Manisha , Puri Abhijeet , Nemade Mahesh
Published: April 2024

This paper explores the transformative impact of computational pharmaceutics, integrating AI, multi-scale modeling, quantum computing, AI-driven drug discovery, and blockchain frameworks. Molecular dynamics simulations provide insights into atomic behaviors crucial for drug design. Quantum computing reduces computational costs for simulating protein-drug interactions. AI and Graph Neural Networks accelerate drug discovery and personalized medicine. Blockchain frameworks facilitate secure pharmacogenetic data sharing. These advancements revolutionize drug development, offering unprecedented efficiency, innovation, and personalized treatments.
Nylons with Applications in Energy Generators, 3D Printing and Biomedicine
Authors: Arioli Matteo , Puiggalí Jordi , Franco Lourdes
Published: April 2024

Linear polyamides, known as nylons, are a class of synthetic polymers with a wide range of applications due to their outstanding properties, such as chemical and thermal resistance or mechanical strength. These polymers have been used in various fields: from common and domestic applications, such as socks and fishing nets, to industrial gears or water purification membranes. By their durability, flexibility and wear resistance nylons have been started to be used in addictive manufacturing technology as a good material choice to get sophisticated devices with precise and complex geometric shapes. Furthermore, the emergence of triboelectric nanogenerators and the development of biomaterials have highlighted the versatility and utility of these materials. In order to enhance the triboelectric performance and the range of applications, nylons show a potential use as tribo-positive materials. Because of the easy control of their shape they can be subsequently integrated into nanogenerators. The use of nylons has also extended into the field of biomaterials, where their biocompatibility, mechanical strength and versatility have paved the way for groundbreaking advances in medical devices as dental implants, catheters and non-absorbable surgical sutures. By means 3D bioprinting nylons have been used to develop scaffolds, joint implants and drug carriers with tailored properties for various biomedical applications. The present paper aims to collect these recently specific applications of nylons by reviewing the literature produced in the last decades, with a special focus on the newer technologies in the field of energy harvesting and biomedicine.
Improving the Clinical Utility of Platelet Count in Primary Care with Age- and Sex-Stratified Upper Thresholds Suggestive of an Undiagnosed Cancer: A Cohort Study Set in Primary Care in England, Canada, and Australia
Authors: Mounce Luke T. A. , Calitri Raff , Hamilton Willie , Rafiq Meena , Emery Jon D. , Giannakeas Vasily , Kotsopoulos Joanne , Bailey Sarah E. R.
Published: April 2024

The platelet count, a component of the full blood count, has been identified as a useful diagnostic marker for cancer in primary care. The reference range for the platelet count is 150 to 400 or 450 × 109/l; this range does not account for natural variation in platelet count by age and sex. This study used three primary care cohorts from England Canada, and Australia. Patients aged 40 years and over with a full blood count were included and stratified by age (in 10-year bands), sex, (male/female), and platelet count group. Cancer incidence within one year of test date was estimated from linked registry data. In all three countries there was a clear upwards trend in cancer incidence with increasing platelet count, for both sexes and at all age groups. Lung and colorectal were the most common sites. These results have important implications for the international application of this work; analysis of local health datasets will be crucial to determine appropriate thresholds. Appropriate upper thresholds will depend on local populations, healthcare needs, and priorities. Further research is needed to assess the likely impact of new recommendations on the healthcare system, on cancer outcomes, and patient benefit.
Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy
Authors: Eissler Nina , Altena Renske , Alhuseinalkhudhur Ali , Bragina Olga , Feldwisch Joachim , Wuerth Guido , Loftenius Annika , Brun Nikolai , Axelsson Rimma , Tolmachev Vladimir , Sörensen Jens , Frejd Fredrik Y
Published: April 2024

Human epidermal growth factor receptor 2 (HER2) is a major prognostic and predictive marker overexpressed in 15- 20 % of breast cancers. The diagnostic reference standard for selecting patients for HER2-targeted therapy is by analysis of tumor biopsies for HER2 expression and amplification. Previously patients were either defined as HER2-positive or negative, however, with approval of novel treatment options, specifically the antibody-drug conjugate trastuzumab deruxtecan, many breast cancer patients with tumors expressing low levels of HER2 and lacking HER2 amplification have become eligible for HER2-targeted therapy. Such patients will need to be reliably identified by suitable diagnostic methods. Biopsy-based diagnostics are invasive, and repeat biopsies are not always feasible. They cannot visualize heterogeneity of HER2 expression, leading to a substantial number of misdiagnosed patients. An alternative and highly accurate diagnostic method is mo-lecular imaging with radiotracers. In case of HER2, various studies demonstrate the clinical utility and feasibility of such approaches. Affibody-based radiotracers are clinically validated molecules with favorable characteristics for imaging. In this article we summarize the HER2-targeted therapeutic landscape, describe the experience with imaging diagnostics for HER2, and review the currently available clinical data on HER2-Affibody-based molecular imaging as novel diagnostic tool in breast cancer and beyond.
Machine Intelligence with Associative Memory and Event-Driven Transaction History
Authors: Mikkilineni Rao , Kelly W. Patrick
Published: April 2024

Digital machine intelligence has evolved from its inception in the form of computation of numbers to AI, which is centered around performing cognitive tasks that humans can perform, such as predictive reasoning or complex calculations. The state of the art includes tasks that are easily described by a list of formal, mathematical rules or a sequence of event-driven actions such as modeling, simulation, business workflows, interaction with devices, etc., and also tasks that are easy to do “intuitively”, but are hard to describe formally or as a sequence of event-driven actions such as recognizing spoken words or faces. While these tasks are impressive, they fall short in applying common sense reasoning to new situations, filling in information gaps, or understanding and applying unspoken rules or norms. Human intelligence uses both associative memory and event-driven transaction history to make sense of what they are observing fast enough to do something about it while they are still observing it. In addition to this cognitive ability, all bio-logical systems exhibit autopoiesis and self-regulation.
In this paper, we demonstrate how machine intelligence can be enhanced to include both associative memory and event-driven transaction history to create a new class of knowledge-based assistants to augment human intelligence. The digital assistants use global knowledge derived from the Large Language Models to bridge the knowledge gap between various participants interacting with each other. We use the general theory of information and schema-based knowledge representation to create the memory and history of various transactions involved in the interactions.
Exosome-Like Systems: From Therapies to Vaccination for Cancer Treatment and Prevention—Exploring the State of the Art
Authors: Sheikhhossein Hamid Heydari , Iommelli Francesca , Di Pietro Natalia , Curia Maria Cristina , Piattelli Adriano , Palumbo Rosanna , Roviello Giovanni N , De Rosa Viviana
Published: April 2024

Cancer remains one of the main causes of death in the world due to its increasing incidence and treatment difficulties. Although several progresses have been done in this field, innovative approaches are needed to reduce tumor incidence, progression and spreading. In particular, the development of cancer vaccines is currently ongoing like both preventive and therapeutic strategy. This concept is not new, but few vaccines have been approved in oncology. Antigen-based vaccination emerges as a promising strategy, leveraging specific tumor antigens to activate the immune system response. However, challenges persist in finding suitable delivery systems and antigen preparation methods. Exosomes (EXs) are highly heterogeneous bilayered vesicles which carry several molecule types in the extracellular space. The peculiarity is that they may be released from different cells and may be able to induce a direct or indirect stimulation of immune system. In particular, EX-based vaccines may cause anti-tumor immune attack or produce memory cells recognizing cancer antigens and inhibit disease appearance. This review delves into EXs composition, biogenesis, and immune-modulating properties exploring their role as tool for prevention and therapy in solid tumors. Finally, here we describe future research directions to optimize vaccine efficacy and realize the full potential of EX-based cancer immunotherapy.