bluuebunny/crossref_metadata_2025 huggingface dataset:
Paternal DEHP Exposure Triggers Reproductive Toxicity in Offspring via Epigenetic Modification of H3K27me3
Authors: Zhang Lu , Yang Rui , Xu Guiyong , Wang Lingqiao , Chen Weiyan , Tan Yao , Zhang Guowei , Liu Wenbin , Zhang Guanghui , Li Jun , Zhou Ziyuan
Published: February 2025

Di (2-ethylhexyl) phthalate (DEHP) is an acknowledged endocrine disruptor with male reproductive toxicity; nevertheless, the transgenerational impacts on male offspring resulting from paternal exposure, along with the mechanisms involved, are not well understood. To develop a transgenerational model of DEHP paternal exposure, male C57BL/6J mice (4-week) exposed to DEHP (5, 250, and 500 mg/kg/d) for 35 days were then bred with unexposed female mice at a ratio of 1:2 to produce offspring. Findings indicate that the sperm quality and relative sex hormones were adversely affected in males of F1 and F2 generations, and pathological damage in the testes and the apoptosis of testicular cells were also observed. Interestingly, an increase in the expression levels of H3K27me3 was observed in the testicular tissues of male descendants. It was further confirmed by in vitro approach that H3K27me3 may down-regulate the expression of Bcl-2 and plays a role in regulating the initiation of apoptosis in Leydig cells triggered by MEHP (the primary metabolite of DEHP). Additionally, the down-regulation of Bcl-2 can be reversed by treatment with the H3K27me3 inhibitor GSK126. To conclude, DEHP leads to transgenerational harm to male offspring reproductive systems, with the epigenetic mechanism of H3K27me3 playing a key role in mediating these effects.
Comment on Karthikeyan et al. Concordance Between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290
Authors: Landwehr Katherine R. , Larcombe Alexander N.
Published: February 2025

Biodiesel exhaust toxicology is a difficult field of study, for which there is a paucity of literature, despite decades of research into the subject [...]
Lineage B Genotype III of Dengue Virus Serotype 3 (DENV-3III_B) Is Responsible for Dengue Outbreak in Dire Dawa City, Ethiopia, 2023
Authors: Negeri Abebe Aseffa , Alemayehu Dawit Hailu , Abrahim Saro Abdella , Wolde Tsigereda Kifle , Tura Gutema Bulti , Bedasso Alemnesh Hailemariam , Geretsion Danile Tsega , Djirata Ebise Abose , Awule Eyilachew Zenebe , Rojas-Gallardo Diana , Korkiso Asefa Konde , Melaku Kalkidan , Joseph Raffael , Ayele Abaysew , Tsegaye Mesfin Mengesha , Piantadosi Anne , Tollera Getachew , Abdissa Alemseged , Dangiso Mesay Hailu , Mihret Adane , Mulu Andargachew , Gelanew Tesfaye
Published: February 2025

The eastern parts of Ethiopia, including Dire Dawa City, have experienced annual dengue fever (DF) outbreaks since 2013, leading to significant healthcare and economic impacts. However, comprehensive evidence on the specific dengue virus (DENV) serotypes and genotypes involved remains limited. During the 2023 DF outbreak, the National Arbovirus Laboratory received seventy serum samples from suspected DF patients. Positive samples underwent sequencing of the CprM region of the DENV genome, and the obtained sequences were analyzed phylogenetically. Among the patients, 32 (45.7%) displayed early warning signs of severe dengue, and 13 were hospitalized, most showing symptoms indicative of severe dengue. Out of 67 adequate samples, 44 (65.6%) tested positive for DENV RNA by RT-PCR, and 17 successfully underwent CprM sequencing. All sequenced samples were identified as DENV-3, genotype III, major lineage B (DENV-3III_B), with two distinct minor lineages (DENV-3III_B.2 and DENV-3III_B.3). Phylogenetic analysis showed that these lineages were closely related to sequences from the Afar region, suggesting interconnected outbreaks with multiple co-circulating lineages. This study identifies DENV-3III_B as the cause of the 2023 DF outbreak in Dire Dawa City and highlights the need for enhanced viral genomic surveillance in Africa.
The Tdap Vaccination in Pregnancy: Results of a Healthy Equity Audit on Coverage Trends and Their Determinants in the Reggio Emilia Province (Italy)
Authors: Bonvicini Laura , Sileo Filomena Giulia , Riboldi Benedetta , Bisaccia Eufemia , Tamelli Marco , Bertani Daniela , Cilloni Silvia , Ghirotto Luca , Giorgi Rossi Paolo
Published: February 2025

Background/Objectives: The Italian National Plan for Vaccine Prevention 2017–2019 recommended tetanus, diphtheria, and acellular pertussis vaccines (Tdap) for pregnant women, irrespectively of their immunization history. This study aims to describe the coverage rate trends for Tdap vaccination in pregnancy and evaluate the differences by socioeconomic status. Methods: This is a retrospective analysis within a health equity audit of the Local Health Authority of Reggio Emilia on vaccination in pregnancy from 2018 (a local vaccination campaign) to 2023. All women residents in our area who gave birth during that period were included and linked to the electronic Registry of Immunization Service. The vaccination coverage in pregnant women was analyzed over time and stratified by pregnant women’s sociodemographic and obstetric characteristics. Results: The coverage of Tdap in pregnant women of the Province of Reggio Emilia increased from 15.9% in 2018 to 53.9% in 2023. The coverage was higher among Italians, women with higher educational levels (aPR 1.49 (CI95%1.41–1.57)), within 31–35 years of age (aPR 1.37 (CI95% 1.28–1.46)), occupied, nulliparous (aPR multiparous vs nulliparous: 0.76 (0.74; 0.78)), and followed in the private sector (aPR 1.07 (1.03–1.11)). Inequalities in coverage increased during the study period for women assisted in the private sector, while decreased or remained stable for women assisted in the context of public services. Conclusions: The vaccination promotion campaign in Reggio Emilia helped increase Tdap coverage in pregnancy from 16 to 53%. Nevertheless, the coverage rates of the most disadvantaged women are still several points lower than the average.
Sustained Immune Persistence Five Years Post-Completion of Four-Dose sIPV Vaccination
Authors: Kai Chu , Yurong Li , Shen Liu , Yongmei Shan , Jianfeng Wang , Xinge Li , Peng Jiao , Hongxing Pan
Published: February 2025

Background: The previous study assessed the immune durability of the Sabin strain inactivated poliovirus vaccine (sIPV) at four years of age; an update on its long-term persistence is warranted. Methods: This Phase IV, open-label, parallel-controlled observational study, required by China’s National Medical Products Administration (NMPA), involves 6.5-year-old children who received four doses of sIPV or Salk IPV (wIPV) at 2, 3, 4, and 18 months during the Phase III trial. Participants are recruited in a 2:1 ratio and contribute blood samples for polio-neutralizing antibody (nAb) assays to determine non-inferiority of immune persistence. Results: The study enrolled 483 participants aged 6.5 years in the 5-year Immune Persistence Set (IPS2), with 318 in the sIPV group and 165 in the wIPV group. Additionally, 387 participants (255 sIPV, 132 wIPV) with samples at six-time points were included in the Full Sequence Immune Persistence Set (IPS3). In IPS2, seropositivity rates (SPRs) for nAbs against serotypes 1–3 were over 99% in sIPV and 98% in wIPV. At 6.5 years, geometric mean titers (GMTs) were significantly higher in the sIPV group 543.96, 179.59 and 362.72 compared to the wIPV group 190.75, 81.05 and 203.95 for serotypes 1, 2 and 3, respectively. Participants in IPS3 demonstrated comparable SPRs and GMTs to IPS2, with values of 566.01 vs. 187.41 for serotype I, 177.55 vs. 78.01 for serotype II, and 365.47 vs. 190.31 for serotype III in the sIPV and wIPV groups, respectively. From one-month post-booster to 6.5 years, nAb GMTs showed declines: 19.35-fold for serotype I, 28.12-fold for serotype II, and 32.45-fold for serotype III in the sIPV group, and 23.42-fold, 23.83-fold, and 34.54-fold in the wIPV group, respectively. Non-inferiority of nAb SPRs and GMTs for sIPV compared to wIPV among participants aged 6.5 years was confirmed for all serotypes in IPS2 and IPS3. Conclusions: The sIPV maintains good immunological persistence five years after four doses of vaccination, with nAb GMT exceeding the seroprotecting threshold, suggesting that booster doses might be currently unwarranted.
Design and Characterization of Bispecific and Trispecific Antibodies Targeting SARS-CoV-2
Authors: Wang Jiayang , Qian Qi , Jiang Yushan , Liang Zuxin , Peng Yun , Zhao Wei , Yang Yang , Shen Chenguang
Published: February 2025

Background/Objectives: COVID-19, caused by SARS-CoV-2, has emerged as a global pandemic since its outbreak in 2019. As an increasing number of variants have emerged, especially concerning variants such as Omicron BA.1, BA.2, XBB.1, EG.5, which can escape the immune system and cause repeated infections, they have exerted significant pressure on monoclonal antibodies and the treatment approaches for COVID-19. Broad spectrum antiviral medication was urgently needed. In this study, we developed several bispecific antibodies based on the IgG-scFv format and one trispecific antibody containing Fab fragments with different anti-virus mechanisms studied previously. The Fab fragments are from h11B11, S2P6, and S309 respectively. Method: all recombinant antibodies were expressed by HEK 293. The pseudoviruses’ neutralization assay and the virus challenge to BALB/c mice were deployed to assess the efficiency of recombinant antibodies in vitro and in vivo. Results: the bispecific antibodies exhibited a favorable pseudoviruses neutralization activity, with IC50 values ranging from 8 to 591 ng/mL. The trispecific antibody performed even better, with IC50 values ranging from 5 to 27 ng/mL. Furthermore, the virus challenge to mice confirmed that the bispecific antibodies, including the trispecific antibody, had decent therapeutic efficacy. Conclusions: our study provided several supplements to the therapeutic measures of COVID-19 based on multispecific antibodies, supporting the great potential of the multispecific antibodies strategy in dealing with emerging pathogens.
Comparative Long-Term Monitoring of Microplastics in the Effluent of Three Different Wastewater Treatment Plants with Two, Three, and Four Treatment Stages
Authors: Sturm Michael Toni , Argyropoulou Daphne , Myers Erika , Korzin Anika , Ronsse Pieter , Zernikel Oleg , Schober Dennis , Schuhen Katrin
Published: February 2025

Wastewater treatment plants (WWTPs) are important point sources for microplastics (MPs) in the environment. For effective mitigation measures and regulations, it is important to monitor their release into the environment and understand the level of MPs in the WWTP effluents based on different treatment technologies. In this study, we compare the MP levels in the effluents of three different municipal WWTPs which each use a different treatment concept: a conventional three-stage WWTP, one with an additional fourth cleaning stage using powdered activated carbon, and a two-stage WWTP utilizing a membrane bioreactor (MBR). Long-term monitoring was performed on the WWTP effluents using the same standardized methods for sample collection, preparation, and detection, based on fluorescent staining. Despite the various advanced treatment processes, there are no significant differences in the resulting MP contamination in the investigation of WWTP effluents. The average MP concentrations in the effluents were 21.8 MPs/L for the conventional three-stage WWTP, 15.1 MPs/L for the four-stage WWTP, and 15.1 MPs/L for the MBR. Further, the MP contamination in all effluents shows a strong fluctuation over time. These findings highlight the need for standard MP monitoring at WWTPs, to gain a better understanding of the MP emission in different treatment processes. Further, it highlights the need for a fourth treatment stage that specifically targets MP removal to effectively prevent the MP release from WWTPs into the environment.
Parental Criticism and Career Confidence in Workers and Students: The Mediating Role of the Fear of an Uncertain Future
Authors: Moavero Cristina , Pace Francesco , Cusimano Giuditta , Sciotto Giulia
Published: February 2025

This study investigates how perceived parental criticism is associated with career confidence in students and workers, considering the mediating role of the fear of an uncertain future. In a rapidly changing labor market, students, as young individuals navigating early career decisions, experience heightened uncertainty about their future, especially regarding their professional paths. This research aims to verify whether perceived parental criticism negatively affects career confidence both directly and indirectly through the mediating role of fear of an uncertain future, and whether occupational status (being a student or already working) influences this relationship. Data were collected from a sample of 310 participants, consisting of 108 students and 202 workers. Multigroup structural equation models were used to test the mediation model simultaneously on students and workers. The results indicate that, in students, the relationship between parental criticism and career confidence is fully mediated by fear of an uncertain future, while in workers these associations are weaker and not significant. These findings suggest that students are more vulnerable to uncertainty, as they are in an early stage of career development, while workers may benefit from greater independence and emotional regulation skills. The study highlights the impact of perceived parental criticism on career confidence and the moderating role of occupational status, suggesting the need for interventions that reduce the fear of an uncertain future and encourage greater adaptability to career-related challenges.
Gestión de efectivo y financiera en empresas de bienes de consumo cotizadas en la Bolsa de Valores de Lima
Authors: Huisa Lagos Jessica Gianina
Published: February 2025

La gestión del efectivo y financiera en empresas de bienes de consumo ha cobrado una relevancia innegable en el escenario empresarial global. El objetivo fue examinar la relación entre la gestión de efectivo y financiera en empresas de bienes de consumo cotizadas en la Bolsa de Valores de Lima 2019-2022. El enfoque fue cuantitativo, tipo explicativo, con diseño documental. La muestra consistió en 240 estados financieros trimestrales de cinco empresas seleccionadas a través de un muestreo no probabilístico. Se utilizó una encuesta como técnica, y una matriz de análisis como instrumento que incluyó indicadores de rentabilidad. Los resultados, revelaron una relación inversa entre gestión de efectivo y rentabilidad (Rho = -0.394, p < 0.05). Se observaron correlaciones negativas entre gestión de efectivo y los índices de rentabilidad analizados. Las conclusiones señalan que un incremento en la gestión de efectivo tiende a asociarse con una disminución en la rentabilidad, respaldando la teoría del trade-off entre liquidez y rentabilidad en el contexto peruano.
Techniques for Compiling Input-Output Tables to Measure the Impact of the Digital Economy in Russia
Authors: Glinskiy V. V. , Serga L. K. , Yushina K. S. , Varnavskiy E. A.
Published: February 2025

As global digital transformation unfolds, analyzing the effects of digital technologies on economics is increasingly important. The choice of better methods and tools for assessing the contribution of digitalization requires further in-depth research. This paper focuses on developing a methodology for measuring the following key indicators of the digital economy, such as development level, dynamics, and linkages between sectors in the context of structural changes in production and consumption at the industry level. The basis of the proposed solution lies in using matrices of coefficients of direct and full material costs obtained based on the Input-Output tables.

Using the data from 2016 to 2020 for the Russian Federation, the authors conducted calculations and identified the economic activities most affected by digital transformation. The developed methodology makes it possible to measure the contribution of the digital economy based on the inter-industry balance, identify key sectors, and propose measures to stimulate digitalization processes. The results of the study can inform managerial decision-making at the country, regional, and industry levels. Open data from the Federal State Statistics Service (Rosstat) served as the information basis of the study.
The impact of financial inclusion on the efficiency of banking systems: an econometric study using panel models for a sample from the G20 Over the period (2005–2023)
Authors: Zoubida Hammadi , Imed Berkane , Djamel Mattoug
Published: February 2025

This study aims to analyze the impact of financial inclusion on the efficiency of banking systems in a sample of G20 countries during the period 2005–2023, using panel data models and Eviews 13. The study focused on measuring the effect of the number of automated teller machines (ATM) per 100,000 adults, the number of commercial bank branches per 100,000 adults, outstanding loans from commercial banks as a percentage of gross domestic product (GDP), and outstanding deposits with commercial banks as a percentage of gross domestic product (GDP) on the efficiency of banking systems, represented by the Net Interest Margin (NIM). The results of the random effects model showed that the number of automated teller machines (ATMs) per 100,000 adults has a positive and statistically significant impact on the efficiency of banking systems, reflecting the role of financial technology in improving banking performance and reducing operational costs. In contrast, the number of commercial bank branches per 100,000 adults was found to have a negative and statistically significant impact, indicating that traditional branch expansion may not be effective in enhancing bank efficiency due to high operational costs. The study also revealed that outstanding deposits and loans from commercial banks as a percentage of gross domestic product have a negative impact on bank efficiency, reflecting challenges in liquidity and credit management in some of the G20 countries. These findings highlight the importance of adopting balanced financial policies that focus on the digital transformation of banking services, improving credit risk management, and implementing effective investment strategies for deposits to ensure the enhancement of banking system efficiency in G20 countries.
Desafíos y retos virales peligrosos en estudiantes de educación media superior en México
Authors: Gómez Nashiki Antonio , Fuentes Vera Leticia
Published: February 2025

El objetivo de este artículo fue analizar el fenómeno de los retos virales peligrosos que se difunden a través de diferentes plataformas y redes sociales. La investigación se apoya en la teoría fundamentada como herramienta de análisis y en entrevistas con estudiantes de educación media superior de tres preparatorias públicas estatales que participaron en diferentes retos, los principales hallazgos son: retos que: a) se caracterizan porque tienen una intencionalidad específica de causar daño a la identidad de los participantes, b) incluyen una narrativa con distintos tipos de violencia: física, verbal, simbólica y psicológica, ya sea en forma de autolesiones de los protagonistas o hacia otros individuos o grupos y c) las motivaciones abarcan una amplia gama que va desde el intento por revertir el aburrimiento, consolidar relaciones sociales y una forma de ejercer poder sobre aquellos que no se atreven a cumplimentar el desafío o los han retado; los entrevistados no consideran sus acciones como peligrosas, menos aún que al realizarlos y difundirlos promuevan un mensaje violento; es un fenómeno creciente entre jóvenes que se asemeja a conductas adictivas con repercusiones severas en la salud emocional. En el caso de las escuelas mexicanas, no existen espacios de formación para docentes en estos temas y la información que se brinda al estudiantado es esporádica, por lo que es necesario reflexionar sobre la inclusión en los espacios curriculares de temas que ayuden a promover la seguridad digital y las buenas prácticas en el uso de plataformas y redes sociales.
Beachcam monitoring of shoreline dynamics
Authors: Crouse Anna , Fallon Kathleen , Bokuniewicz Henry
Published: February 2025

Long-term periodic monitoring on New York’s ocean shoreline showed that, despite waxing and waning in the course of any year, beaches have maintained a stable average width between about 200 and 300 feet. To examine the shorter-term patterns of change in the beach width, camera images were calibrated to allow beach widths to be determined. Beach widths measured at low tide varied between less than 60 feet to more than 175 feet between January 2023 and the end of January 2024. A pattern of modulation showed a quasi-cyclical behavior with periods between 5 and 15 days. This seems consistent with the classic synoptic periods of between two and seven days for the passage of mesoscale weather systems. Large variations seem to coincide with wave activity monitored 30 nautical miles south of Long Island (NOAA station 44025) as represented by a “Dalrymple Parameter”1 (Dp) and taking into account wave height, period and sediment settling speed. Beach widths increased at a rate of about 2.5 feet per week as wave activity decreased over the summer.
Arachis hypogaea Bitkisi Kullanılarak Yeşil Sentezi Gerçekleştirilen Gümüş Nanopartiküllerin Antimikrobiyal ve Anti Quorum Sensing Aktivitelerinin Tespiti
Authors: Aktaş Taylan
Published: February 2025

Yer fıstığı (Arachis hypogaea L.), ağırlıklı olarak Akdeniz bölgesi olmak üzere Türkiye ve Amerika Birleşik Devletleri'nde dikkate değer bir öneme sahip, dünya çapında yetiştirilen önemli bir tarım ürünüdür. Bu araştırmada Osmaniye ilinden elde edilen yer fıstığı, araştırma çalışmalarımızın ana malzemesi olarak kullanılmıştır. Nanopartiküller, çağdaş bilimsel araştırmalar içinde çeşitli disiplinlerde kullanılmaktadır. Bu alanlardaki en kritik araştırmalar arasında, özellikle çeşitli mikroorganizmalar üzerindeki ölümcül etkileri nedeniyle antibiyotiklerin incelenmesi bulunmaktadır.Bu çalışmada A. hypogaea bitkisine ait tohum ve kabuklar ile gümüş nanopartiküllerin (AgNP) yeşil sentezi gerçekleştirilmiştir. Sentezlenen AgNP’ler; antimikrobiyal ve anti-quorum sensing aktivite açısından analiz edilmiştir. Antimikrobiyal aktivite analizi amacıyla çalışmada 22 adet patojen mikroorganizma kullanılmıştır. Sonuç olarak; AgNP’lerin antimikrobiyal aktivitelerinde istatistiksel açıdan anlamlı farklar tespit edilmiştir (p0,05). Çalışmada kullanılan Chromobacterium violaceum, AgNP’lerin en yüksek antimikrobiyal aktivite gösterdiği mikroorganizma olmuştur. AgNP’lerin C. violaceum üzerinde göstermiş oldukları antimikrobiyal etki, anti-quorum sensing aktiviteninde olduğunu sonuçlarda göstermiştir. Fıstık ve kabuk ile yeşil sentezi gerçekleştirilen AgNP’ler, Anti-QS açısından istatistiksel olarak anlamlı farklara da neden olmuştur (p0,05). 2,5 μl/ml konsantrasyondaki yaş, çiğ ve kavrulmuş yer fıstığı tohumu ile yeşil sentezi gerçekleştirilmiş AgNP’lerde zon çapları sırasıyla 19,2 mm, 18,6 mm, 19,4 mm iken, yer fıstığı kabuğu ile yeşil sentezi gerçekleştirilmiş AgNP’lerde sırasıyla 16,8 mm, 16,8 mm, 14,8 mm’dir. Özellikle mikroorganizmaların antibiyotiklere ve diğer terapötik ajanlara karşı önemli ölçüde yüksek direnç seviyeleri sergilediği gerçeği ışığında hem ekonomik olarak uygulanabilir hem de etkili olan bu malzemeler ilaç sektöründe ve diğer alanlarda dikkate alınmayı hak etmektedir.
Effect of Fartlek and Sand Trainings on Selected Physical Fitness Variables among University Men Students
Authors: Karthikeyan P.
Published: February 2025

The purpose of the study was to find out the effects of fartlek training [FT] and Sand training [ST] on selected physical fitness components namely muscular endurance [ME] and cardiorespiratory endurance [CRE] among university men students. To achieve this purpose of the study, forty-five men students studying men students studying Department of Physical Education, Annamalai University, Chidambaram, Tamil Nadu, India were selected as subjects at random. Their age ranged between 18 to 24 years. The selected subjects were divided into three equal groups of fifteen each namely fartlek training group [FTG], Sand training group [STG] and control group [CG]. The experimental group I underwent fartlek training [FT] and group II underwent Sand training [ST] for three days per week for twelve weeks whereas the control group maintained their daily routine activities and no special training was given to them. The following physical fitness components, namely muscular endurance [ME] and cardiorespiratory endurance [CRE] were selected as criterion variables. The subjects of the three groups were tested on selected physical fitness components namely muscular endurance and cardiorespiratory endurance using standardized tests namely bend knee sit-ups and Cooper’s 12 min Run / Walk test at prior and immediately after the training period. The collected data were analyzed statistically through analysis of covariance (ANCOVA) to find out the significant difference, if any among the groups. Whenever the obtained F ratio was found to be significant, the Scheffe’s test was applied as post hoc test to find out the paired mean difference, if any. The .05 level of confidence was fixed to test the level of significance which was considered appropriate. The results of the study showed that there was a significant difference exist among FTG, STG and CG on selected physical fitness components namely ME and CRE. And also, FTG and STG showed significant improvement on ME and CRE when compared to control group.
Impact of Leadership Style on Job Satisfaction among the Library Professionals in Tamilnadu
Authors: Arumugam J. , Radha L.
Published: February 2025

Library professionals are deeply passionate about the vital role libraries play in providing access to information, supporting learning and literacy, and strengthening communities. Many of them take on leadership roles within library organizations, advocating for the resources and policies needed to enhance library services. They actively engage with stakeholders to highlight the value of libraries and the work of library professionals. Beyond their leadership roles, these professionals bring a wealth of knowledge, expertise, and dedication to their work, making a significant impact on the mission and values of libraries worldwide. This study looks at the key factors influencing job satisfaction among library professionals in Tamil Nadu, with a particular focus on how leadership styles contribute to their overall job satisfaction.
Biodiversity Hotspots in India and Environment Protection under the Constitution of India
Authors: Satish Kumar S.
Published: February 2025

India is considered as a Subcontinent as it contains various elements of nature. Nature has been cherished and protected throughout History. History is not only about humans but also about nature. This Indian History is an edifice built on nature. The constitution of India insists on protecting the environment. In this article we will see about the four biodiversity hotspots in India and the constitutional provisions that insist on protecting the environment. The diversity of plant and animal species in a particular habitat is referred to as biodiversity. The two main factors that make up biodiversity are species evenness and species richness. India is renowned for having a diverse ecosystem, and with 23.39% of its land covered by trees and forests, there are nearly 91,307 identified animal species and 45,523 documented plant species. India is unique in that it is one of the 12 countries with the highest biodiversity in the world. Four of the world’s 36 biodiversity hotspots are located in India: The Himalayas, Western Ghats, Indo - Burma and Sundaland.
Пожарная обстановка в лесах юга Дальнего Востока на примере Хабаровского и Приморского краев
Authors: Орлов А.М. , Андреев Ю.А. , Чаков В.В. , Позднякова В.В. , Громыко О.С. , Грищенова Ю.А.
Published: February 2025

В статье рассмотрены актуальные вопросы, касающиеся лесопожарной обстановки на юге Дальнего Востока, для которого характерны высокая продолжительность пожароопасного сезона и пики пожарной опасности. В качестве исходных данных использовались сведения федеральной и отраслевой статистики, отчеты органов государственного управления, научные публикации, а также собственные исследования авторов. Приведен анализ причин возникновения пожаров, их количества и площадей, продолжительности пожароопасного сезона, пространственного (географического) распределения за последние несколько лет на примере Приморского и Хабаровского краев. Учитывая разнообразие экономических, природно-климатических и лесорастительных условий анализ пожарной опасности производился в сравнении не только между двумя субъектами, но и между лесными районами, входящими в них – Дальневосточным таежным и Приамурско-Приморским хвойно-широколиственным. По результатам анализа сформулированы предложения по планированию профилактических противопожарных мероприятий, направленные на снижение горимости в этих субъектах.

The article discusses current issues related to the forest fire situation in the south of the Far East. The initial data used was federal and industry statistics, reports from government agencies, scientific publications, as well as the authors’ own research. An analysis of the causes of fires, their number and area, the duration of the fire season, spatial (geographic) distribution over the past few years is provided using the example of the Primorsky and Khabarovsk territories. Taking into account the diversity of economic, natural-climatic and forest conditions, fire hazard analysis was carried out in comparison not only between the two subjects, but also between the forest areas included in them - the Far Eastern taiga and the Amur-Primorsky coniferous-deciduous. Based on the results of the analysis, proposals were formulated for planning preventive fire prevention measures aimed at reducing fire rates in these regions.
Управление процессом определения рационального обеспечения подразделений МЧС России, расположенных на территории Арктической зоны РФ
Authors: Смирнов А.С. , Балобанов А.А. , Новиков В.Р. , Пряничников А.В.
Published: February 2025

Проблема обеспечения защищенности населения и территорий Арктической зоны Российской Федерации в настоящее время стоит крайне остро, поскольку данный регион имеет стратегически и экономически важное значение. Инфраструктура, позволяющая обеспечивать безопасность на данной территории должна отвечать высоким требованиям и стандартам, что обусловлено тяжелыми климатическими условиями региона. В статье рассматривается подход к разработке системы критериев и показателей определения рационального состава комплекса техники, технических средств, оборудования, имущества, экипировки и снаряжения, обеспечивающего наиболее эффективное выполнение всего спектра задач подразделениями МЧС России в условиях Арктической зоны Российской Федерации. В рамках представленной статьи рассматривается пример определения оптимального состава техники. Представлен алгоритм выделения существенных показателем и продемонстрирован пример практического применения данного алгоритма.

The problem of ensuring the protection of the population and territories of the Arctic zone of the Russian Federation is currently extremely acute, since this region is strategically and economically important. The infrastructure to ensure security in this area must meet high requirements and standards, due to the harsh climatic conditions of the region. The article considers an approach to the development of a system of criteria and indicators for determining the rational composition of a complex of equipment, technical means, equipment, property, equipment and equipment that ensures the most effective performance of the entire range of tasks by units of the Ministry of Emergency Situations of Russia in the Arctic zone of the Russian Federation. An algorithm for identifying significant indicators is presented and an example of practical application of this algorithm is demonstrated.
Science Capital: Results from a Finnish Population Survey
Authors: Kaakinen Johanna K. , Havu-Nuutinen Sari , Häikiö Tuomo , Julku Hanna , Koskela Teija , Mikkilä-Erdmann Mirjamaija , Pihlajamäki Milla , Pritup Daria , Pulkkinen Kirsi , Saarikivi Katri , Simola Jaana , Wikström Valtteri
Published: February 2025

This study examined science capital among Finnish adults (N=1,572), who responded to 37 survey items assessing science capital. Factor analysis suggested four science capital dimensions: visiting science-related places, science attitudes, science-related self-efficacy, and early support for studying natural sciences. Higher education and higher parental education were linked to higher science capital across all dimensions. Older participants exhibited lower science-related self-efficacy, less early support, and more negative science attitudes than younger respondents. Age and education were stronger predictors of science-related self-efficacy and early encouragement for men than women, and mothers’ education had a weaker effect on science-related self-efficacy for men. The results show that science capital is a multidimensional construct and highlights that younger generations in Finland have had more opportunities to develop their science capital. These findings emphasize the need for early and equitable support to foster positive science attitudes and participation, crucial for enhancing public acceptance of scientific information.
HUBUNGAN PENGETAHUAN DAN SIKAP TENTANG KEK DENGAN PERILAKU PANTANG MAKANAN IBU HAMIL KEK DI PUSKESMAS TOROH 1
Authors: Hapsari Wahyu Dewi , Ekasari Wahyu Utami , Yuwanti Yuwanti
Published: February 2025

Latar Belakang: Kasus ibu hamil KEK di Dinas Kesehatan Kabupaten Grobogan telah mencapai 1.778 pada tahun 2022. Kejadian KEK Ibu hamil ini diketahui meningkat di wilayah Puskesmas Toroh I dari 85 kasus pada tahun 2022 menjadi 99 kasus di bulan Januari – Agustus tahun 2023. Pemerintah telah mengupayakan menurunkan angka prevalensi ibu hamil KEK dengan pelayanan antenatal care rutin dan pemberian makanan tambahan minimal selama 90 hari, namun karena kurangnya pengetahuan dan perilaku pantangan tertentu ibu hamil, menjadikan pencapaian target penurunan prevalensi KEK menjadi terhambat Tujuan: Mengetahui hubungan pengetahuan dan sikap tentang KEK pada perilaku pantang makanan Ibu hamil KEK di Puskesmas Toroh 1. Metode: Survey analitik menggunakan desain cross-sectional, dengan pengambilan teknik total sampling sebanyak 30 responden. Hasil: Sebagian besar Ibu hamil KEK di wilayah kerja Puskesmas Toroh 1 berpengetahuan baik (46,7%), memiliki sikap positif (80%), tidak memiliki perilaku pantang makanan (83,3%), uji chi square menunjukkan p value = 0,001 pada hubungan antara pengetahuan dengan perilaku pantang makanan dan p value = 0,000 pada hubungan antara sikap dengan perilaku pantang makanan ibu hamil KEK.Simpulan: Ada hubungan pengetahuan dan sikap terhadap perilaku patang makanan ibu hamil KEK di Puskesmas Toroh 1.
Online Guest Book Application for Computer Science Department at Bina Bangsa University
Authors: Permana Basuki Rakhim Setya , Auliana Sigit , Rohman Ali , Munawir Ahmad , Mulyawansyah Ahmad Andika
Published: February 2025

Information technology is currently useful for automating various processes and activities that were previously done manually. Now human activities are turning into computerized systems. Information that is presented quickly and precisely greatly influences the level of work efficiency and effectiveness in various fields.
This research uses the waterfall method, which is a software development process model which is a sequential and linear approach. This approach relies on sequential and progressive stages, where each stage must be completed before entering the next stage.
Based on the results of the research and discussions that have been carried out, it can be stated that with this web-based guest book application, it is hoped that the input, data collection and recording processes can be more effective and efficient and the security of data storage will be more guaranteed
Designing an Application for Direct Cash Assistance Allocation Using Laravel at Sepang District Office
Authors: Sunardi Sunardi , Auliana Sigit , Pratama Gelard Untirtha , Permana Basuki , Nugraha Asep Darma
Published: February 2025

This research aims to design an information system for receiving direct cash assistance funds at the Sepang sub-district office, the sub-district can use this system to make it easier to receive direct cash assistance funds. Researchers use the PHP programming language, assisted by the Laravel Framework, and use MYSQL as a database. For the software development stage, use the saw method. Data collection techniques in research use observation, interviews and literature studies. The results of this research are an application for determining the receipt of direct cash assistance funds in the Sepang sub-district which is expected to make it easier for the sub-district to implement the receipt of direct cash assistance funds.
Design Of Computer Network Communication In JASDAM II Sriwijaya With Top-Down Method
Authors: Alvian Pratama  , Aan Restu Mukti  , Fatoni  , Zaid Amin
Published: February 2025

The need for reliable and extensive network infrastructure in a military environment, especially in Jasdam II Sriwijaya, is becoming increasingly important along with the security tasks and challenges faced. This research aims to design a network that meets military standards and performance by applying the Top-Down method. The Top-Down method in the context of network design, along with network needs analysis in a military environment. Through this approach, this research aims to strengthen operations and expand the network in Jasdam II Sriwijaya. The research methodology includes data collection on network needs, needs analysis, Top-Down design, implementation, and testing. The expected results of this research are the design of a network structure at 3 locations that are in accordance with well-defined military needs, as well as expanding network communications in a military environment, measuring how well the network is using the QoS method. This research provides optimal network infrastructure development in JASDAM II Sriwijaya, with the potential for a wider scale.
Metabolite-Group Selection On Temu Ireng (Curcuma Aeruginosa) Contains Related To Toxicity Activity By Using Group Lasso Regression
Authors: H S Rahmat , Afendi Farit Mochamad , Hari Wijayanto
Published: February 2025

Metabolites are expressed in mass-to-charge ratio (m/z) on mass spectrometry experiments. They can be identified more than once. Some of m/z representing same metabolites can be considered as a group of metabolites. Evaluation of metabolite effects can be considered based on the groups. Group least absolute shrinkage and selection operator (group lasso) regression can be used to evaluate these groups. It shrinks some coefficients of regression exactly to be zero by adding intermediate penalty on ordinary least square (OLS) objective function. The purposes of this study were to estimate groups of metabolite contains of Curcuma aeruginosa (Temu ireng) affecting toxicity activity by using group lasso regression and to compare it to partial least square regression (PLSR). The data used were toxicity activity and metabolite contain, obtained from LC-MS, of temu ireng from three areas in Java. The groups of metabolites which affected toxicity activity, of group lasso regression by using dedicated software of R with gglasso package, were groups of m/z 238.150, 250.165, 262.128, 264.144, 312.275, and 456.183. The estimates of metabolites that affected of group lasso regression and PLSR had similarities. Based on the goodness of fit, group lasso regression was better than PLSR to estimate the affecting groups.
Implementation of Green Innovation, Supply Chain Management and Technology Capability on Business Performance of Micro, Small and Medium Enterprises
Authors: Mardikaningsih Rahayu
Published: February 2025

Entrepreneurship has been recognized as a mechanism for generating economic benefits. However, due to the emergence of the concept of business performance as a pressing issue affecting the global system today, it has been proposed that MSMEs, which stands for micro, small and medium enterprises, should also be given special attention. Therefore, this study intends to investigate the viewpoints of MSME entrepreneurs from green innovation, supply chain management, and technological capability to business performance in micro, small, and medium-sized enterprises (MSMEs). The study adopted a quantitative approach and involved multiple linear regression analysis tools. This study targets a population of 100 MSMEs operating in Surabaya City. Accidental sampling will be used for sampling. The study results indicate that green innovation has a significant positive impact on MSME business performance. This innovation involves the implementation of practices that support environmental sustainability, such as the utilization of environmentally friendly materials, effective waste management, and green measures. In addition, the study also shows that efficiency in supply chain management and a high level of technological capability also contribute significantly to MSME business performance.
Application of Copywriting Strategy in Brodo Active Commercial Video Production
Authors: Wirabumi Arya Wibowo , Nugrahani Rah Utami , Priastuty Chairunnisa Widya
Published: February 2025

The creative industry in Indonesia has developed very rapidly, it is shown that the creative economy in Indonesia contributes 7.5% of Indonesia's gross domestic product (GDP). One of the creative industries that is developing very rapidly is the fashion industry. Brodo is a fashion company that was founded in 2010 and initially operated in the leather shoe sector, and now has expanded its reach by having a new section on sports shoes. Brodo itself is one of the companies that has carried out digital marketing to introduce the products they have. One type of digital marketing they have is commercial advertising videos. At the end of 2023, Brodo will launch 2 of their sports shoe products, namely Brodo Mezzala and Inizio Running, which do not yet have an introductory video to market their products in the form of commercial advertising videos. Therefore, the researcher conduct research entitled "Application of Copywriting Strategy in the Production of Brodo Active Commercial Advertising Videos". The theory used by the researcher in this research is copywriting theory with several supporting indicators to be able to represent and provide an interesting message to the audience. To be able to obtain data as a basis for this research, the researcher conducted observations, interviews and questionnaires. The object of this researcj has a duration of one minute and three seconds with the title "Brodo Active Perfomance – Mulai Bergerak" as a commercial advertising video which aims to be an introductory video for Brodo Mezzala and Inizio Running.
Persuasive Communication Strategy in Preventing Child Marriage through the Marriage Age Maturation Program in Sirau Village, Purbalingga Regency
Authors: Mumtingah Suciarti , Iman Sulaiman Adhi , Prastyanti Shinta
Published: February 2025

The purpose of this study is to persuasive communication strategy in preventing child marriage through the marriage age maturation program.  This research is qualitative research that used the constructivism paradigm. The research was located in Sirau Village, Karangmoncol District, Purbalingga Regency. The selected unit of analysis is the implementation of the Marriage Age Maturation (PUP) program in Sirau Village, Purbalingga Regency. There are two types of data used in this research, namely primary data and secondary data. The primary data used are the results of observations and in-depth interviews. Secondary data from this research were obtained through library research and literature relevant to the research. The persuasive communication strategy carried out by BKKBN through the Marriage Age Maturation (PUP) program can be seen from activity groups in the form of Youth Family Development (BKR) and the Youth Counseling Information Center (PIK-R), Qualified Family Planning (PKB) instructors through clear message and creative media.
Improving Science Learning Outcomes Through Problem Based Learning Methods in Class IV SDN 176 Palembang
Authors: Wahyuni Asri , Annisa Satia  , Cythia Ingga Pratiwi  , Clara Dara Mania  , Desi Ulfa Sari
Published: February 2025

This research discusses the use of Problem Based Learning (PBL) to improve student learning outcomes in learning science and technology regarding plant body parts in class IV.C at SDN 176 Palembang. The research was carried out using the classroom action research (PTK) method which includes two cycles, including planning, implementation, observation, and reflection. The research results show a significant increase in student learning completion after implementing PBL. Before the cycle, only 40% of students had completed the KKM, increasing to 64% in the first cycle and 88% in the second cycle. PBL has proven to be effective in increasing students' understanding and motivating them to think critically and creatively in solving problems related to science material.
Analysis Of Student’s Diagnostic Ability in Electricity And Magnetism’s Course Based on Quizziz Platform.
Authors: Rifda Nur Hikmahwati Arif  , Sitti Rahma Yunus  , Nurul Fakhrannisa  , Salma Samputri  , Rifda Mardian Arif
Published: February 2025

This study aims to analyse the diagnostic ability of ICP science students FMIPA UNM in the Electricity and Magnetism course. This research uses descriptive research with a Quizizz-based qualitative approach. The sampling technique used was purposive sampling. The data collection technique used in this study was a multiple choice diagnostic test accessed through the Quizizz platform online. The data analysis technique used is descriptive statistics (frequency, percentage, and average) and item analysis (index of difficulty and differentiating power of the questions. Quizizz-based diagnostic tests for electrical and magnetic topics are effective enough to evaluate students' initial abilities. Most questions have a moderate difficulty level and sufficient to good differentiating power; however, some questions have low or negative differentiating power and need to be corrected. The results showed that students' diagnostic ability in Electricity And Magnetism’s Course using quizziz platform was at 5,0 score which in a low category. This research serves as a basis for the development of better diagnostic tests to achieve learning objectives.
Integration of English Songs as Learning Media for the Improvement of Descriptive Writing
Authors: Inzhagi Muh. Aditya , Sunra La , Muhalim Muhalim
Published: February 2025

This study examines the effectiveness of English songs in enhancing students' descriptive writing skills in a senior high school in Takalar, involving 36 tenth-grade students. A pre-experimental design was utilized, incorporating pre-tests and post-tests to assess writing performance before and after the intervention. Results showed a significant improvement, with average post-test scores increasing from 63.8 to 82.6. Paired t-test analysis confirmed this enhancement, revealing a mean difference of 18 points and a t-value of 6.066 (p < 0.05). The N-Gain score of 0.46 indicates moderate overall improvement. These findings suggest that English songs serve as effective authentic materials, engaging students and improving their content organization, vocabulary usage, and grammatical accuracy, particularly in the simple present tense. This research underscores the value of using English songs as a teaching tool to enhance descriptive writing skills, offering valuable insights for educators.