bluuebunny/crossref_metadata_2025 huggingface dataset:
Crédito para financiar a inovação tecnológica nas propriedades rurais
Authors: Sterle Luiz Gustavo de Góes , Amorim Domingos Isaias Maia
Published: May 2024

O principal instrumento da política agrícola brasileira é o crédito rural, características intrínsecas à produção agropecuária, como o descasamento temporal entre despesas e receitas, faz com que o capital de giro seja fundamental para sustentação da atividade. O montante disponibilizado via Plano Safra 2021/2022 foi de R$ 251,22 bilhões, sendo R$ 177,78 bilhões para custeio, comercialização e industrialização, e R$ 73,44 bilhões para investimentos. O objetivo deste trabalho foi realizar um estudo acerca do crédito rural para financiar a inovação na atividade agropecuária, a exploração levou ao programa Inovagro, onde se buscou analisar a evolução histórica de adoção desta modalidade de crédito na região sul do Brasil, devido a mesma apresentar maior relevância para o programa. O estudo se caracteriza como pesquisa aplicada, com objetivo exploratório, de abordagem qualitativa, cujo procedimento de coleta de dados foi pesquisa bibliográfica, os dados utilizados neste estudo foram coletados no sistema do BNDES, são dados históricos do período de 2013 a 2021 e retratam informações sobre desembolso, quantidade de contratos e porte da empresa, os dados foram organizados, tabelados e gráficos gerados para fins de análise, utilizando o programa Microsoft Excel. O estado do Paraná foi o que apresentou maiores valores para os parâmetros analisados, apesar da queda desses valores no ano de 2021. O gráfico do tíquete médio indicou uma tendência de alta a partir do ano de 2017. O porte das empresas tomadoras de crédito do programa são majoritariamente micro e pequenas, os quais são responsáveis por 97% de participação no programa.
Reabilitação cardiopulmonar para pacientes submetidos à cirurgia cardíaca pós-alta hospitalar: Revisão integrativa
Authors: Lima Raiani Stefany dos Santos Silva , Dantas Kaliny Oliveira , Lopes Augusto Cesar Bezerra , Carvalho Epamela Sulamita Vitor de
Published: May 2024

As doenças cardiovasculares são consideradas um problema de saúde pública responsável por uma alta taxa de mortalidade. Indivíduos com doenças cardíacas podem ser submetidos a tratamentos clínico e/ou cirúrgico, sendo o cirúrgico responsável por complicações clínicas e funcionais. Um meio de prevenir essas complicações é através da reabilitação cardiopulmonar- RC com início ainda na UTI. O objetivo do estudo foi reunir evidências a respeito da RC em pacientes submetidos à cirurgia cardíaca a fim de prevenir ou minimizar as complicações pós-alta hospitalar. Trata-se de uma revisão integrativa da literatura, baseada em artigos que investigaram a RC em pacientes submetidos à cirurgia cardíaca após alta hospitalar. A pesquisa seguiu algumas recomendações do PRISMA e estratégia PICO. Utilizadas cinco bases de dados: PubMed, Scopus, Web of science, Lilacs e SciELO. Os descritores de ciências em saúde (DeCS/MeSH), criado pela BIREME: Thoracic Surgery, Cardiac Rehabilitation, Postoperative Care, Educational Technology, Cardiac Surgical Procedures, Physical Therapy Specialty, Exercise e Enhanced Recovery After Surgery. Encontrados um total de 19.380 artigos, sendo eleitos 6 artigos. Os quais evidenciaram melhora na capacidade funcional e função física quando submetidos a um protocolo de exercícios aeróbicos e cinesioterapia ativa. A RC mostrou a melhora na capacidade funcional mais rapidamente e na qualidade de vida a curto e longo prazo. No entanto, os resultados ainda se mostram conflitantes, que podem estar relacionados à intensidade, série e adesão dos exercícios, fazendo necessário que mais estudos e protocolos sejam desenvolvidos, a fim de consolidar com mais evidências os seus efeitos a longo prazo.
Trauma abdominal: Avaliação, prioridades cirúrgicas e estratégias de ressuscitação em casos de emergência
Authors: Galvão Amanda Albuquerque Cursino Barbosa , Soares Romerio Alves , Oliveira Ane Caroline Rodrigues de , Alves Victor Goes Cavalcanti , Silva Carlos André Souto , Melo Rodrigo Alberto Braz Cavalcante de , Rocha Brendo Tenório , Souto Maria Eduarda Aires , Leite Lucelia Vital , Cordeiro Lisandra Karoll Torres Pinheiro , Silva Aldemir Cavalcante da , Ramos Davi Silva , Araujo Elison Lins , Moura Felipe Alves Celestino de
Published: May 2024

Este estudo, teve como objetivo investigar a eficácia e a viabilidade de um protocolo de triagem e manejo precoce do trauma abdominal em ambientes de emergência, visando otimizar a identificação precoce de lesões intra-abdominais, priorizar intervenções cirúrgicas e estratégias de ressuscitação, e melhorar os desfechos clínicos e a sobrevida dos pacientes. A metodologia selecionada para a realização desta pesquisa, trata-se de um estudo do tipo revisão narrativa da literatura, onde realizou-se um levantamento de dados nas bases científicas: LILACS e SCIELO. Os resultados mostraram que a implementação de um protocolo de triagem e manejo precoce do trauma abdominal em ambientes de emergência é uma estratégia crucial para melhorar os desfechos clínicos e a sobrevida dos pacientes. Estudos recentes têm enfatizado a importância de uma abordagem sistemática e rápida na identificação precoce de lesões intra-abdominais, priorizando intervenções cirúrgicas e estratégias de ressuscitação. A adoção de um protocolo de triagem baseado em evidências demonstrou uma redução significativa no tempo até o diagnóstico de lesões intra-abdominais, resultando em uma menor mortalidade entre os pacientes com trauma abdominal grave.
Como a pandemia pela COVID-19 impactou nos atendimentos urgentes de traumas odontológicos em um hospital público de referência: Um estudo retrospectivo
Authors: Costa Vitor Antunes Martins da , Peixoto Vitória Carolaine de Oliveira , Jardim Lorena Barbosa , Silva Ana Carla Vaz de Souza e , Resende Renata Gonçalves , Leijôto-Lannes Amanda Carolina Neiva , Lopes-Silva Jhonathan
Published: May 2024

O objetivo do trabalho foi verificar se há diferença nos padrões de atendimento e na incidência dos casos de trauma odontológicos em um hospital público de referência, antes e durante a pandemia pela COVID-19. Foi realizado um estudo transversal retrospectivo dos prontuários odontológicos no serviço de urgência e emergência do Hospital Municipal Odilon Behrens, pertence ao Sistema Único de Saúde (SUS), de março a dezembro dos anos de 2019 e 2020. Para comparar os padrões de atendimento, fez-se análise descritiva, teste do qui-quadrado de Pearson e exato de Fisher, com nível de significância de 95%. Observou-se redução de 52% dos atendimentos durante a pandemia, com mudanças estatisticamente significativas (p<0,005) nos tipos (redução de traumas craniofaciais/ aumento dos traumas dentoalveolares e corto-contusos) e nas causas (aumento dos traumas associados a acidentes domésticos / redução dos relacionados a acidentes esportivos) de traumas odontológicos. Esse trabalho possui relevância para a compreensão do impacto da pandemia nos serviços de saúde pública. A escolha de um hospital de referência possibilitou análise impacto da pandemia na odontologia. Esses resultados fornecem subsídios para investigações futuras sobre o impacto da pandemia nos serviços odontológicos públicos.
Avaliação da qualidade de sono de gestantes de alto risco internadas em uma maternidade pública
Authors: Silva Maria Antônia Alves da , Macedo Marylia da Costa , Feitosa Maura Cristina Porto , Macêdo Sara Sampaio de , Portela Fabiana Teixeira de Carvalho , Lima Andréa Conceição Gomes
Published: May 2024

Objetivos: Avaliar a qualidade do sono em gestantes de alto risco internadas. Metodologia: Trata-se de um estudo observacional de natureza transversal e analítica. Os métodos quantitativos foram realizados em uma maternidade pública de referência de alta complexidade. Foi realizada amostragem não probabilística, intencional e de conveniência. Foi aplicado o índice de Pittsburgh. Resultados: 23 gestantes apresentaram boa qualidade do sono e 7 apresentaram qualidade ruim. Os resultados referentes às características sociodemográficas das gestantes mostraram que a faixa etária prevalente foi a das gestantes acima de 35 anos (36,7%), 53,3% das grávidas concluíram o ensino secundário, 30% não concluíram o ensino secundário e 13,3% concluíram o ensino superior, a maior prevalência dentre as gestantes da pesquisa foi para as mulheres que tiveram até três gestações (80%), seguido das gestantes multíparas (20%), que são aquelas que tiveram mais de três gestações. O desconforto na hora de dormir mais listado foi a dor lombar. Conclusão:  Concluiu-se que, a qualidade do sono em gestantes de alto risco hospitalizadas é boa, embora existam associações significativas como o aumento do volume abdominal afetando negativamente os padrões de sono materno.
Transição do hospital para o domicílio: Inquietações de familiares e cuidadores de idosos em cuidados paliativos
Authors: Rosa Jessica Maria de Almeida , Teixeira Maria Luiza de Oliveira , Branco Elen Martins da Silva Castelo , Silva Barbara Martins Correa da , Gonzalez Christiany Moçali
Published: May 2024

Objetivos: descrever as necessidades de orientações dos familiares e cuidadores de idosos em cuidados paliativos no contexto da alta hospitalar para o domicílio. Método: estudo descritivo de abordagem qualitativa. Foram incluídos como participantes da pesquisa, familiares e cuidadores de pacientes em cuidados paliativos com indicação e/ou probabilidade de indicação de alta hospitalar para o domicílio, com idade igual ou maior de 18 anos.  Resultados: preocupações e sentimentos: ansiedade; alívio; preocupação com a mudança da rotina e como se dará a divisão do cuidado entre os outros familiares e cuidadores e pelo temor do paciente falecer no domicílio. Dúvidas sobre as demandas dos cuidados no domicílio, foram destacados: oxigenoterapia, cuidados com lesões por pressão e alimentação. Conclusão: Necessário implementar intervenções que melhorem, entre outras questões, a comunicação entre os profissionais e o usuário na preparação e educação para o cuidado em casa, com oferta de redes de apoio comunitário e tratamento precoce do luto.
Adesão em terapia antirretroviral: Revisão de escopo
Authors: Conceição Warlene do Socorro Xavier da , Lima Gustavo Campos de , Soler Orenzio
Published: May 2024

Introdução: Na Terapia Antirretroviral a adesão ao tratamento farmacoterapêutico proposto é de fundamental importância para a garantia da supressão viral do HIV, aumentando a longevidade e garantido qualidade de vida as pessoas que vivem com HIV/AIDS. Objetivo: Mapear os principais fatores que influenciam na adesão ao tratamento farmacoterapêutico do HIV/AIDS; bem como, as estratégias utilizadas para alcançar a adesão. Metodologia: Revisão de escopo guiada pelo acrônimo PCC em que: Participantes: pessoas vivendo com HIV/AIDS; Conceito: não adesão a Terapia Antirretroviral; Contexto: serviços de Saúde. Resultados: Foram recuperados 15 artigos, os quais demostram os motivos de não adesão mais comuns e a importância do uso de estratégias para melhoria da adesão. Conclusão: Encontrou-se evidencias de que a utilização de estratégias para a adesão a Terapia Antirretroviral é eficazes/efetivas no tratamento farmacoterapêutico do HIV/AIDS.
Influence of parasites on spawning success and egg quality in Antarctic krill Euphausia superba
Authors: Cleary AC , Perry F , Tarling GA
Published: May 2024

Antarctic krill Euphausia superba are key components of Southern Ocean ecosystems and biogeochemical cycles, as well as the target of a growing commercial fishery. Understanding the drivers of variability in krill recruitment is key to managing this fishery sustainably. One potential driver which has received little attention is the role of parasites. We investigated the impact of natural parasite infestations in adult female krill on egg production and egg quality around South Georgia. DNA metabarcode sequencing was used to detect all eukaryotic parasites within krill bodies, while spawning success was determined through incubation experiments, and egg quality was assessed by quantifying key elements within each egg (carbon, nitrogen, hydrogen). E. superba in this area were infested with suctorian ciliates, eugregarine apicomplexans, and, less frequently, ellobiopsids. Parasite load was not associated with a reduced likelihood of producing eggs, but high parasite loads were associated with lower-quality eggs. This reduction in egg quality may reflect an energetic cost to parasite infestation, with implications for larval development and recruitment.
PERSEPSI SISWA SMA N 3 BANDAR LAMPUNG TERHADAP PEMBELAJARAN MASA DEPAN MENGGUNAKAN VIRTUAL REALITY
Authors: Azzahra St Fatimah
Published: May 2024

Abstrak
Teknologi yang berkembang sangat cepat di abad ke 21 ini memberikan dampak dalam berbagai sisi kehidupan salah satunya adalah dalam dunia pendidikan. Kemajuan teknologi berbasis komputer dan smartphone merupakan trend saat ini. Perkembangan teknologi dalam dunia pendidikan misalnya adalah munculnya media atau sumber belajar yang berbasis pada teknologi seperti media pembelajaran dengan Virtual Reality berbasis web (VR). Virtual Reality berbasis web (VR) merupakan suatu terobosan baru di dunia pendidikan untuk dapat membuat suatu inovasi yang akan berdampak pada peningkatan minat siswa untuk belajar materi kimia. Virtual Reality merupakan suatu media yang menggabungkan antara text, animasi, video, gambar, serta audio dalam satu aplikasi. Penelitian yang digunakan adalah dengan metode dekriptif kualitatif dengan memberikan produk penelitian VR di kelas lalu disebarkan angket persepsi siswa SMA terhadap VR. Hasil penelitian menunjukkan bahwa persepsi siswa terhadap media menggunakan virtual reality.
Pendidikan Keluarga: Perang Orang Tua terhadap Pembentukan Karakter Remaja Di Gereja Kristen Jawa Cilacap Utara
Authors: Wiryadinata Halim , Boiliu Noh Ibrahim , Hidayat Udin Firman , Purba Sudiarjo
Published: May 2024

Perubahan sosial yang cepat akibat perkembangan teknologi dan ekonomi digital telah memberikan dampak signifikan terhadap pertumbuhan moralitas remaja. Teknologi telah menggeser perilaku dan sikap remaja pada orientasi pada teknologi itu sendiri, sehingga moralitas mengalami distrupsi. Ekonomi digital, di sisi lain, menguatkan pergeseran nilai-nilai moralitas yang berdasar pada kekuatan ekonomi digital itu sendiri. Kondisi ini menyebabkan moralitas remaja mengalami ketidakseimbangan di dalam komunitas masyarakat. Penurunan moralitas remaja dalam era digitalisasi merupakan permasalahan bangsa, sehingga memerlukan penyuluhan terhadap peran orang tua. Peranan orang tua dalam pembentukan karakter remaja, khususnya di Gereja Kristen Jawa (GKJ) Cilacap Utara, menjadi prioritas dalam pengembangan program GKJ. Nilai moralitas menjadi prioritas pada penyuluhan atas pembentukan nilai pendidikan moral melalui peranan orang tua. Penyuluhan ini menjadi sebuah gerakan untuk membangun nilai moralitas melalui peranan orang tua. Oleh karena itu, penyuluhan pendidikan keluarga melalui peranan orang tua dalam pembentukan karakter remaja di GKJ Cilacap Utara. Pembentukan karakter anak remaja menjadi suatu prioritas utama bagi GKJ Cilacap Utara sebagai tulang punggung jemaat masa depan.
PEMBERDAYAAN RELAWAN BALARAJA MELALUI PELATIHAN MENULIS KARYA ILMIAH DAN MENULIS SASTRA
Authors: Samosir Astuti , Haryanti Ade Siti , Nafilah Ila
Published: May 2024

Bahasa mampu menjangkau semua kalangan, organisasi atau budaya manusia, termasuk tulisan. Seperti kita ketahui bahwa saat ini media sosial sangat banyak diminati oleh semua kalangan. Pengabdian kepada Masyarakat yang dilaksanakan di desa Tobat, Tangerang. Kegiatan ini bertujuan untuk memberikan pemahaman akan pentingnya kalimat hoak. Pengamatan tim abdimas yang merupakan warga   desa Tobat bahwa masih terdapat ibu-ibu yang dengan mudahnya menyebarkan informasi melalui media sosial tanpa mencari tahu kebenarannya.  Selain itu, ibu-ibu menjadi korban berita hoak yang ada. Observasi tim abdimas terhadap media social ibu-ibu juga masih terdapat penyebaran berita hoak. Metode yang dilakukan dalam pelaksanaan PKM ini adalah metode sosialisasi,      berbagi pengalaman, diskusi bersama dan PLA. Beberapa hasil kegiatan abdimas ini yaitu pertama, program ini berhasil memberikan pemahaman terhadap ibu-ibu di desa Tobat akan berita hoak, kedua, Sampai saat ini, para ibu masih suka berkomunikasi dengan tim abdimas berkenaan dengan berita hoak, ketiga, para anak dan remaja juga perlu mendapatkan sosialisasi terhadap berita hoak.
 
Kata Kunci: Kalimat Hoax, Media Sosial, Facebook, Ibu-ibu desa Tobat
EDUKASI MENGELOLA KEUANGAN BAGI PELAKU UMKM DI LINGKUNGAN UNIVERSITAS KRISTEN INDONESIA
Authors: Purnama Riwandari Juniasti , Fery Tobing  , Edison Siregar  , Trihanna Kezya Rima  , Belinda Oktavian
Published: May 2024

PKM ini bertujuan untuk mengatasi permasalahan yang dihadapi oleh UMKM di lingkungan UKI (kantin) saat mahasiswa libur dengan fokus pada edukasi mengelola keuangan usaha UMKM. Saat mahasiswa libur, kantin menghadapi penurunan pendapatan, surplus persediaan, risiko keuangan, dan hambatan pertumbuhan. Oleh karena itu, melalui PKM ini mencoba mengatasi masalah ini melalui pendekatan edukasi. Edukasi yang dilakukan adalah edukasi mengenai pengelolaan keuangan, pembukuan sederhana, solusi pembayaran digital dan aktifasi platform online.
Dari hasil diskusi yang dilakukan selama kegiatan diperoleh hasil bahwa sebagian besar peserta belum melakukan aktifasi penjualan secara online dengan menggunakan platform tertentu, belum memisahkan keuangan pribadi dan usaha, belum melakukan pembukuan atas kegiatan usahanya, dan masih ragu menggunakan Qris sebagai alternatif pembayaran dari pembeli. Setelah dilakukan penyuluhan peserta menyatakan ingin melakukan pembukuan dengan baik, ingin melakukan penjualan secara online, serta ingin menggunakan Qris. Perlu pendampingan yang berkelanjutan agar peserta dapat meningkatkan pendapatan kantinnya dengan melalui penjualan online sehingga pada saat mahasiswa libur tidak terjadi penurunan pendapatan serta perlu pendampingan agar peserta dapat melakukan pembukuan usahanya dengan baik, sehingga dapat mengetahui apakah usahanya menghasilkan dan efisien. Serta perlunya monitoring penggunaan Qris dari pihak bank tempat peserta membuka Qris agar setiap permasalahan terkait Qris dapat segera diselesaikan.
Kata kunci : Edukasi, Pengelolaan Keuangan, UMKM
Investigation of Breast Milk Use in Early Childhood and Its Psychobiochemical Effects
Authors: Vardağlı Duygu , Çetin Furkan Fatih
Published: May 2024

Aim: The periods in which the infant is fed only by breast-feeding (food: breast milk), and the period in which the infant can stay in contact with breast milk (nutrient: breast milk + food X) maximum by breast-feeding, and KSS score distributions in these periods were investigated.
Material and Methods: In the research; Individuals between the ages of 18-25 were asked questions about the early childhood-infancy periods, to determine the duration of breast milk intake and breastfeeding, and the distribution of the scores they received was examined by applying the KSS. The Cronbach Alpha coefficient (0.723) was calculated to determine the Turkish validity and reliability of the Kerns Secure Scale. The data were collected digitally, and the minimum sample size was determined as 176 people with the G*Power (v3.1.9.7) program. In the research, data belonging to 209 people were studied, and SPSS 26 statistical program was used to determine the data. p
D Vitamini Eksikliği Çölyak Hastalığı İçin Bir Risk mi?
Authors: Yurt Türer Büşra , Ekici Emine Merve
Published: May 2024

Son yıllarda yapılan çalışmalar, D vitamininin esas olarak doğuştan gelen ve kazanılmış bağışıklıkla ilgili modülasyonu yoluyla birçok iskelet dışı işlevi yerine getirebileceğini göstermiştir. Bundan yola çıkarak D vitamininin Çölyak gibi otoimmün bozuklukların gelişimi, klinik seyri ve tedavisinde temel bir rol oynayabileceğini öne sürülmüştür.
Çölyak hastalığı (ÇH), diyet glutenine intolerans ile karakterize otoimmün özellikleri olan ince bağırsağın enflamatuar bir hastalığıdır. Günümüzde prevelansı dünya nüfusunun neredeyse %1’ine ulaşmış olup en yaygın otoimmün bozukluklardan biridir. ÇH’nın patogenezinde başlıca çevresel faktör glutendir ve glutensiz diyet çölyak tedavisinin temel dayanağı olmaya devam etmektedir. Ancak glutensiz diyetin ÇH’lı çocuklarda ve yetişkinlerde beslenme yetersizliğini önlemede yeterli olmadığı bildirilmiştir. Yapılan çalışmalarda çölyak hastalarında kontrol grubuna göre 25(OH)D vitamin seviyelerinin daha düşük olduğu, glutensiz diyet tedavisi sonrası yükselmesine rağmen yeterli seviyeye ulaşamadığı gösterilmiştir. ÇH’da kemik mineral yoğunluğu ve kütlesinin azalması, kemik kırılganlığının ise artması Çölyak hastalığının bazı klinik belirtilerinin önemli nedeni olarak görülmektedir.
D vitamininin ÇH’nın ortaya çıkmasında ve seyrinde gastrointestinal sistem ve bağışıklık sistemi üzerine çeşitli mekanizmalar yoluyla potansiyel etkisi görülmektedir. Glutensiz diyet tedavisi sırasında D vitamini takviyesinin daha fazla kemik kaybını önlediği, osteomalazi ile ilişkili semptomları iyileştirdiği ve kalsiyum seviyelerini normalleştirdiğine yönelik kanıtlar olsa da literatürde D vitamininin etkinliğine dair veriler çelişkilidir. Bununla birlikte, uzmanların çoğu başlangıçtaki veya glutensiz diyet sırasındaki D vitamini seviyelerine ve yaşa bakılmaksızın ÇH'lı tüm bireylerde sistematik olarak D vitamini serum seviyesi takibinin yapılmasını ve belgelendiğinde D vitamini eksikliğinin düzeltilmesini tavsiye etmektedir.
Spinoza, Marx and Anti-Oedipus: A Labour Theory of Repression
Authors: Thomas Kevin K.
Published: May 2024

This paper contemplates repression as a factor of production in Anti-Oedipus. Repression is part of the division of labour which defines the composition of the labour–capital relation, what Deleuze and Guattari conceive of as a differential relation. In interpreting Deleuze and Guattari’s concepts of repression, commentaries have elaborated on the influences of Marx’s theories of reification and of the state. However, the influence of Marx’s theory of division of labour in capitalism has not been fully examined. This theory, which involves dispossession of intellectual potentialities and suppression of productive drives, is essential to Deleuze and Guattari’s Spinozist hypothesis that the masses came to desire fascism under a particular set of historical conditions. Through a reading of Capital, guided by Balibar’s reading in particular, and an analysis of schizophrenia in alignment with Foucault’s, Deleuze and Guattari develop a theory of repression as immanent to production. Based in this theory, they conceive of fascism as a line of flight from the limits of capital, emerging among several counteracting factors against the tendency for the rate of profit to fall. In assessing how repression operates in Deleuze and Guattari’s form of psychoanalysis, this paper references Marx’s Capital and Spinoza’s Ethics as well as Balibar’s contribution to the 1965 book Reading Capital and Foucault’s 1962 Mental Illness and Psychology. The paper concludes with remarks on the further development of this theory in Deleuze and Guattari’s 1980 A Thousand Plateaus and Deleuze’s 1990 ‘Postscript on Control Societies’.
Benteng Wuna: Tantangan Golongan Bangsawan Muna di Era Modern
Authors: Langaja Amin
Published: May 2024

Fort Wuna as evidence of the residential separation of the Muna noble class shows that the social stratification system still applies in Muna even though many people still have middle to lower economic conditions. This research aims to find out what challenges are faced by the Muna noble class in the modern era with middle to lower economic conditions. The theory used in this research is Everyday Form of Resistance by James C. Scott. By using ethnographic methods, it was found that the Muna aristocrats who are in the middle to lower economic conditions must always maintain traditions by performing life cycle rituals that require a lot of money. The tactics used in overcoming these problems are by way of donations from relatives and superimposing their children in the procession of life cycle rituals carried out by other noble families.
Fenomena Tubuh Perempuan dalam Anime Kimi no Na Wa
Authors: Zamaludin Nu'man , Prabasmoro Tisna , Adipurwawidjana Ari Jogaiswara
Published: May 2024

Indonesia, with its multicultural society, has many traditions/ Kimi no Na Wa (Your Name) is an anime displaying the reality of gender and women in a complex way. This complexity can be seen in the narrative displayed, namely the exchange of bodies between female and male characters. This article questions the phenomenon of women and their bodies in this anime. The analysis used phenomenological theory of perception with a descriptive analysis method. The result shows that the phenomenon of body exchange between men and women confirms gender issues that are not tied to sex. The exchange of bodies also indicates women's endeavor to change them from what were previously associated with rural and traditional into modern ones. In addition, the phenomenon of body exchange also emphasizes that the body is an essential element of human existence.
Tradisi Papajar dan Tradisi Munggahan dalam Perspektif Sosio–Kultural Masyarakat Cianjur
Authors: Rahmawati Dini Siti , Mufti Justika Ainun , Parhan Muhamad
Published: May 2024

Indonesia, with its multicultural society, has many traditions/cultures, including Muslims when the Holy Month of Ramadan comes. Muslims in each region have diverse traditions. This includes Cianjur people who have papajar and munggahan traditions. Papajar tradition is the one usually held today by going on excursions and eating together with the family to tourist attractions which is carried out one or two weeks before the month of Ramadan. Meanwhile, munggahan tradition is carried out in Cianjur community by gathering with family and relatives, botram or eating together, forgiving each other, praying, visiting graves which is done one or two days before the month of Ramadan. This research aims to understand values, beliefs and cultural practices underlying papajar and munggahan traditions. This research uses qualitative literature study methods from book, previous research and internet sources. What will be examined in this research are papajar tradition and munggahan tradition in welcoming the holy month of Ramadan from the socio-cultural perspective of the Cianjur community. The result of research shows that papajar and munggahan traditions are two of many traditions commonly carried out by Cianjur people, and in practice these two traditions essentially contain mutual cooperation, solidarity, tolerance, order and togetherness.
Performansi Alat Uji Getaran Kendaraan Model Satu Roda Terhadap Pengaruh Gelombang Jalan
Authors: Pipit Wahyu Nugroho  , Utsman Syah Amrullah  , Khambali  , Achmad Walid
Published: May 2024

Kenyamanan penumpang kendaraan beserta kestabilan dalam mengendarainya adalah salah satu variabel penting yang selalu diinginkan oleh setiap orang yang menggunakan alat transportasi. Guna mencapai tujuan tersebut, maka bagian suspensi kendaraan akan memegang peranan penting karena fungsinya yang mengisolasi penumpang dari pengaruh eksitasi dari luar kendaraan dan mengatur kestabilan kendaraan agar roda tetap menempel di permukaan jalan. Performansi setiap suspensi sangat perlu untuk diuji sehingga bisa dianalisis kondisinya serta jika dimungkinkan untuk dikembangkan suatu suspensi yang lebih baik unjuk kerjanya.
Dalam penelitian ini dirancang model alat uji getaran kendaraan satu roda yang dipakai untuk menguji kenyamanan dan kestabilan kendaraan. Perancangan diawali dari komponen transmisi penggerak dari motor ke komponen profil jalan, dalam hal dimensi, bentuk dan material penyusunnya. Komponen permukaan jalan ini berupa motor, camshaft, connecting rod, plat permukaan jalan, poros pendukung dan roda. Setiap komponen itu dirakit menjadi satu kesatuan sistem alat uji dan akan disimulasikan pergerakannya. Perancangan ini berbasis pada Computer Aided Design dengan perangkat lunak Catia.
Pengujian model kendaraan dilakukan secara simulasi dengan gaya eksitasi berupa gelombang sinusoidal dan fungsi step dengan variasi jenis suspensi, baik yang soft, medium dan hard. Hasil pengujian menunjukkan respon yang bagus. Suspensi jenis Soft dan Medium bisa menangani getaran dengan sangat baik terutama dari tingkat kecepatan responnya untuk jalan yang relatif rata. Sementara itu Suspensi jenis Hard sangat baik meredam getaran untuk jalan yang bergelombang.
Experimental evaluation of performance of geo-mat system on weak to intermediate subgrade
Authors: Jawad Saif , Han Jie , Liu Hao
Published: May 2024

Geo-mat system is considered as an alternative to a flexible or rigid pavement that can be used for fire lanes, parking areas, or roadway shoulders for cars, pickup trucks, utility/delivery trucks, and fire trucks. Also, it can be used to reduce the thickness of the base course in unpaved roads. In this investigation, six cyclic loading tests were conducted to assess the efficacy of the geo-mat system on weak to intermediate subgrade layers, characterized by California Bearing Ratios (CBR) of 2%, 3%, and 4%. Control sections, consisting of a 300-mm thick base course over subgrade layers with CBR values of 2% or 4%, were compared against the test sections comprising a geo-mat system placed atop aggregates of varied thickness (150 or 50 mm) on a geotextile layer over the same subgrade layers. Each test section underwent cyclic loading, progressively increasing from 17.8 to 71.2 kN using a 300-mm diameter steel plate. The results demonstrate that the geo-mat system, particularly when placed over a 150 mm-thick aggregate base, exhibited comparable or superior performance to the control sections with a 300 mm thickness, especially under substantial cyclic loading. This was evidenced by the reduced permanent deformations beneath the loading plate and a wider load distribution. The increase of the subgrade CBR value reduced the permanent deformation significantly. When the intermediate subgrade with a 4% CBR was used, the geo-mat system played a more important role than the aggregate base and the base thickness had a minor effect on the performance.
Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility
Authors: Nguyen Tuyen Thi Thanh , Tokuhiro Keizo , Shimada Keisuke , Wang Haoting , Mashiko Daisuke , Tonai Shingo , Kiyozumi Daiji , Ikawa Masahito
Published: May 2024

Since the advent of gene-targeting technology in embryonic stem cells, mice have become a primary model organism for investigating human gene function due to the striking genomic similarities between the two species. With the introduction of the CRISPR/Cas9 system for genome editing in mice, the pace of loss-of-function analysis has accelerated significantly. This has led to the identification of numerous genes that play crucial roles in male reproductive processes, including meiosis, chromatin condensation, flagellum formation in the testis, sperm maturation in the epididymis, and fertilization in the oviduct. Despite the advancements, the functions of many genes, particularly those enriched in male reproductive tissues, remain largely unknown. In our study, we focused on 15 genes and generated 13 gene-deficient mice [4933411K16Rik, Adam triple (Adam20, Adam25, and Adam39), BC048671, Cfap68, Gm4846, Gm4984, Gm13570, Nt5c1b, Ppp1r42, Saxo4, Sh3d21, Spz1, and Tektl1] to elucidate their roles in male fertility. Surprisingly, all 13 gene-deficient mice exhibited normal fertility in natural breeding experiments, indicating that these genes are not essential for male fertility. These findings have important implications as they may help prevent other research laboratories from duplicating efforts to generate knockout mice for genes that do not demonstrate an apparent phenotype related to male fertility. By shedding light on the dispensability of these genes, our study contributes to a more efficient allocation of research resources in the exploration of male reproductive biology.
The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein
Authors: O’Brien Brittany C. V. , Thao Shelly , Weber Lahra , Danielson Helen L. , Boldt Agatha D. , Hueffer Karsten , Weltzin Maegan M.
Published: May 2024

The rabies virus enters the nervous system by interacting with several molecular targets on host cells to modify behavior and trigger receptor-mediated endocytosis of the virion by poorly understood mechanisms. The rabies virus glycoprotein (RVG) interacts with the muscle acetylcholine receptor and the neuronal α4β2 subtype of the nicotinic acetylcholine receptor (nAChR) family by the putative neurotoxin-like motif. Given that the neurotoxin-like motif is highly homologous to the α7 nAChR subtype selective snake toxin α-bungarotoxin (αBTX), other nAChR subtypes are likely involved. The purpose of this study is to determine the activity of the RVG neurotoxin-like motif on nAChR subtypes that are expressed in brain regions involved in rabid animal behavior. nAChRs were expressed in Xenopus laevis oocytes, and two-electrode voltage clamp electrophysiology was used to collect concentration-response data to measure the functional effects. The RVG peptide preferentially and completely inhibits α7 nAChR ACh-induced currents by a competitive antagonist mechanism. Tested heteromeric nAChRs are also inhibited, but to a lesser extent than the α7 subtype. Residues of the RVG peptide with high sequence homology to αBTX and other neurotoxins were substituted with alanine. Altered RVG neurotoxin-like peptides showed that residues phenylalanine 192, arginine 196, and arginine 199 are important determinants of RVG peptide apparent potency on α7 nAChRs, while serine 195 is not. The evaluation of the rabies ectodomain reaffirmed the observations made with the RVG peptide, illustrating a significant inhibitory impact on α7 nAChR with potency in the nanomolar range. In a mammalian cell culture model of neurons, we confirm that the RVG peptide binds preferentially to cells expressing the α7 nAChR. Defining the activity of the RVG peptide on nAChRs expands our understanding of basic mechanisms in host-pathogen interactions that result in neurological disorders.
Effect of three oral pathogens on the TMA-TMAO metabolic pathway
Authors: Wang Xixuan , Chen Liyuan , Teng Ye , Xie Weige , Huang Lingyan , Wu Juan , Wang Hongwei , Xie Sijing
Published: May 2024

Background

Trimethylamine-N-oxide (TMAO) is produced by hepatic flavin-containing monooxygenase 3 (FMO3) from trimethylamine (TMA). High TMAO level is a biomarker of cardiovascular diseases and metabolic disorders, and it also affects periodontitis through interactions with the gastrointestinal microbiome. While recent findings indicate that periodontitis may alter systemic TMAO levels, the specific mechanisms linking these changes and particular oral pathogens require further clarification.

Methods

In this study, we established a C57BL/6J male mouse model by orally administering Porphyromonas gingivalis (P. gingivalis, Pg), Fusobacterium nucleatum (F. nucleatum, Fn), Streptococcus mutans (S. mutans, Sm) and PBS was used as a control. We conducted LC-MS/MS analysis to quantify the concentrations of TMAO and its precursors in the plasma and cecal contents of mice. The diversity and composition of the gut microbiome were analyzed using 16S rRNA sequencing. TMAO-related lipid metabolism and enzymes in the intestines and liver were assessed by qPCR and ELISA methods. We further explored the effect of Pg on FMO3 expression and lipid molecules in HepG2 cells by stimulating the cells with Pg-LPS in vitro.

Results

The three oral pathogenic bacteria were orally administered to the mice for 5 weeks. The Pg group showed a marked increase in plasma TMAO, betaine, and creatinine levels, whereas no significant differences were observed in the gut TMAO level among the four groups. Further analysis showed similar diversity and composition in the gut microbiomes of both the Pg and Fn groups, which were different from the Sm and control groups. The profiles of TMA-TMAO pathway-related genera and gut enzymes were not significantly different among all groups. The Pg group showed significantly higher liver FMO3 levels and elevated lipid factors (IL-6, TG, TC, and NEFA) in contrast to the other groups. In vitro experiments confirmed that stimulation of HepG2 cells with Pg-LPS upregulated the expression of FMO3 and increased the lipid factors TC, TG, and IL-6.

Conclusion

This study conclusively demonstrates that Pg, compared to Fn and Sm, plays a critical role in elevating plasma TMAO levels and significantly influences the TMA-TMAO pathway, primarily by modulating the expression of hepatic FMO3 and directly impacting hepatic lipid metabolism.
Broadening the audience for science engagement with machine-learning techniques
Authors: Crettaz von Roten Fabienne
Published: May 2024

In Switzerland, the need to engage the public in science is rooted in the political system with its tools of initiatives, therefore the broadening of the audience is critically important. Using the 2021 Science and Technology Eurobarometer, we propose solutions by using machine-learning techniques which identified patterns of engagement and the interaction of sociodemographic characteristics that constitute the prediction (1) of lowest level of science engagement and (2) of non-visitors to the science and technology museum. The techniques allow a more precise targeting than traditional segmenttion analyses.
V-A ECMO for neonatal coxsackievirus B fulminant myocarditis: a case report and literature review
Authors: Li Xingchao , Sun Li , Xi Shibing , Hu Yaofei , Yu Zhongqin , Liu Hui , Sun Hui , Jing Weili , Yuan Li , Liu Hongyan , Li Tao
Published: May 2024

Background

Neonatal (enteroviral) myocarditis (NM/NEM) is rare but unpredictable and devastating, with high mortality and morbidity. We report a case of neonatal coxsackievirus B (CVB) fulminant myocarditis successfully treated with veno-arterial extracorporeal membrane oxygenation (V-A ECMO).

Case presentation

A previously healthy 7-day-old boy presented with fever for 4 days. Progressive cardiac dysfunction (weak heart sounds, hepatomegaly, pulmonary edema, ascites, and oliguria), decreased left ventricular ejection fraction (LVEF) and fractional shortening (FS), transient ventricular fibrillation, dramatically elevated creatine kinase-MB (405.8 U/L), cardiac troponin I (25.85 ng/ml), and N-terminal pro-brain natriuretic peptide (NT-proBNP > 35,000 ng/L), and positive blood CVB ribonucleic acid indicated neonatal CVB fulminating myocarditis. It was refractory to mechanical ventilation, fluid resuscitation, inotropes, corticosteroids, intravenous immunoglobulin, and diuretics during the first 4 days of hospitalization (DOH 1–4). The deterioration was suppressed by V-A ECMO in the next 5 days (DOH 5–9), despite the occurrence of bilateral grade III intraventricular hemorrhage on DOH 7. Within the first 4 days after ECMO decannulation (DOH 10–13), he continued to improve with withdrawal of mechanical ventilation, LVEF > 60%, and FS > 30%. In the subsequent 4 days (DOH 14–17), his LVEF and FS decreased to 52% and 25%, and further dropped to 37%–38% and 17% over the next 2 days (DOH 18–19), respectively. There was no other deterioration except for cardiomegaly and paroxysmal tachypnea. Through strengthening fluid restriction and diuresis, and improving cardiopulmonary function, he restabilized. Finally, notwithstanding NT-proBNP elevation (>35,000 ng/L), cardiomegaly, and low LVEF (40%–44%) and FS (18%–21%) levels, he was discharged on DOH 26 with oral medications discontinued within 3 weeks postdischarge. In nearly three years of follow-up, he was uneventful, with interventricular septum hyperechogenic foci and mild mitral/tricuspid regurgitation.

Conclusions

Dynamic cardiac function monitoring via real-time echocardiography is useful for the diagnosis and treatment of NM/NEM. As a lifesaving therapy, ECMO may improve the survival rate of patients with NM/NEM. However, the “honeymoon period” after ECMO may cause the illusion of recovery. Regardless of whether the survivors of NM/NEM have undergone ECMO, close long-term follow-up is paramount to the prompt identification and intervention of abnormalities.
The carbon release triggered by 1.32 Ga sill emplacement and its potential environmental implications
Authors: Zhang Chaokun , Tian Wei , He Yanxin , Gong Mingyue , Li Shun
Published: May 2024

Magmatic activity is one of the important pathways for the delivery of deep Earth carbon to the surface. The massive carbon release in this process can have significant impacts on atmospheric-oceanic environment. Previous studies have done a lot of work on the relationship between Phanerozoic magmatic activity and carbon release, but there is relatively limited attention has been given to investigating the association between Precambrian magmatic activity and carbon release. The Yanliao Large Igneous Province at 1.32 Ga exhibits extensive development of sills, and the reaction between sills and surrounding rocks triggers the release of carbon. Simultaneously, the magmatic activity during this period is considered as the final response to the breakup of the Columbia supercontinent, coinciding with the occurrence of the Mesoproterozoic Oxygenation Event To explore the connection between this magmatic activity and global carbon cycling, environmental changes and planetary evolution, nine representative stratigraphic columns are selected from the Yanliao area. We use the SILLi 1.0 1D model by utilizing the one-dimensional finite element method (FEM) to simulate and estimate the amount of carbon release triggered by sill emplacement. The simulation results indicate that the emplacement of sills increased the surrounding rock temperature and vitrinite reflectance, leading to a decrease in the total organic carbon (TOC) content. A large amount of organic carbon and inorganic carbon was released, which was initiated by the reaction between sills and surrounding rocks, with a total carbon release up to 1.24 × 1013 tons. The estimated CO2 equivalent released during this magma activity episode is expected to be greater than 4.58 × 1013. In Mesoproterozoic strata, the emplacement of sills activates carbon within the lithosphere could have implications for the global environment. Further work needs to be done in other ancient cratons that possess Lower Riphean strata to find additional evidence of the impact of this magmatic event on the Earth system. From this study, it is evident that magmatic activity during the Precambrian period could promote the activation of carbon in crustal sediments and influence global environment, which can a reference for people to understand the planetary evolution process.
Large scale implementation of effective early literacy instruction
Authors: Gillon Gail , McNeill Brigid , Scott Amy , Gath Megan , Macfarlane Angus , Taleni Tufulasi
Published: May 2024

Introduction

Large-scale implementation of Multi-Tiered Systems of Support (MTSS) to enhance children's early literacy success is critically important to address global literacy challenges. This paper describes one such initiative, the Better Start Literacy Approach (BSLA), which was specifically designed for large-scale implementation in New Zealand.

Methods

Between February 2020 and May 2023 over 3,000 teachers in 819 schools across New Zealand implemented BSLA, with baseline data available for 29,795 5-year-old children. Teachers implemented novel online assessments to monitor children's early literacy growth.

Results

In comparison to an internal control group, accelerated progress in children's phonic, and phoneme awareness skills was evident after 10 weeks of BSLA Tier 1 (universal) teaching. After 30 weeks, there were significant gains in word reading, spelling, listening comprehension and oral narrative abilities; growth did not differ based on gender, ethnicity, or socioeconomic status. Children with greater learning needs who received BSLA Tier 2 (small group targeted teaching) caught up to their peers in word reading and spelling skills.

Conclusions

With appropriate resourcing, planning and engagement with communities, successful large-scale implementation of evidenced-based early literacy approaches is possible within a relatively short time. Culturally responsive implementation within MTSS frameworks holds much promise for raising literacy achievement for all children.
Accuracy of a novel real-time continuous glucose monitoring system: a prospective self-controlled study in thirty hospitalized patients with type 2 diabetes
Authors: Ge Shenghui , Zhang Hui , Wang Jun , Li Huiqin , Su Xiaofei , Ding Dafa , Ma Jianhua
Published: May 2024

Aims

The present study aimed to investigate the accuracy of the Glunovo® real-time continuous glucose monitoring system (rtCGMS).

Methods

We conducted a 14-day interstitial glucose level monitoring using Glunovo® rtCGMS on thirty hospitalized patients with type 2 diabetes. The flash glucose monitoring (FGM) was used as a self-control. Consistency tests, error grid analysis, and calculation of the mean absolute relative difference (MARD) were performed using R software to assess the accuracy of Glunovo® rtCGMS.

Results

Glunovo® exhibited an overall MARD value of 8.89% during hospitalization, compared to 10.42% for FGM. The overall percentages of glucose values within ±10%/10, ± 15%/15, ± 20%/20, ± 30%/30, and ±40%/40 of the venous blood glucose reference value were 63.34%, 81.31%, 90.50%, 97.29%, and 99.36% for Glunovo®, respectively, compared with 61.58%, 79.63%, 88.31%, 96.22% and 99.23% for FGM. The Clarke Error Grid Analysis showed that 99.61% of Glunovo® glucose pairs and 100.00% of FGM glucose pairs within zones A and B.

Conclusion

Our study confirms the superior accuracy of Glunovo® in monitoring blood glucose levels among hospitalized patients with type 2 diabetes.
Daytime plasma cortisol and cortisol response to dexamethasone suppression are associated with a prothrombotic state in hypertension
Authors: Brosolo Gabriele , Da Porto Andrea , Bulfone Luca , Vacca Antonio , Bertin Nicole , Vivarelli Cinzia , Catena Cristiana , Sechi Leonardo A.
Published: May 2024

Background and aims

A prothrombotic state was demonstrated in patients with Cushing’s syndrome and is involved in the development and progression of cardiovascular and renal damage in hypertensive patients. This study was designed to examine the relationships between cortisol secretion and the hemostatic and fibrinolytic systems in hypertension.

Methods

In 149 middle-aged, nondiabetic, essential hypertensive patients free of cardiovascular and renal complications, we measured hemostatic markers that express the spontaneous activation of the coagulation and fibrinolytic systems and assessed daily cortisol levels (8 AM, 3 PM, 12 AM; area under the curve, AUC-cortisol) together with the cortisol response to dexamethasone overnight suppression (DST-cortisol).

Results

Plasma levels of D-dimer (D-dim), prothrombin fragment 1 + 2 (F1 + 2), and von Willebrand factor (vWF) were progressively and significantly higher across tertiles of AUC-cortisol and DST-cortisol, whereas no differences were observed in fibrinogen, tissue plasminogen activator, plasminogen activator inhibitor-1, antithrombin III, protein C, and protein S. D-dim, F1 + 2, and vWF were significantly and directly correlated with age and both AUC-cortisol and DST-cortisol. Multivariate regression analysis showed that both AUC-cortisol and DST-cortisol were related to plasma D-dim, F1 + 2, and vWF independently of age, body mass index, blood pressure, and renal function.

Conclusion

Greater daily cortisol profile and cortisol response to overnight suppression are independently associated with a prothrombotic state in hypertensive patients and might contribute to the development of organ damage and higher risk of cardiovascular complications.