bluuebunny/crossref_metadata_2025 huggingface dataset:
Results of Phase III Randomized Trial for Use of Docetaxel as a Radiosensitizer in Patients With Head and Neck Cancer, Unsuitable for Cisplatin-Based Chemoradiation
Authors: Patil Vijay Maruti , Noronha Vanita , Menon Nandini , Singh Ajay , Ghosh-Laskar Sarbani , Budrukkar Ashwini , Bhattacharjee Atanu , Swain Monali , Mathrudev Vijayalakshmi , Nawale Kavita , Balaji Arun , Peelay Zoya , Alone Mitali , Pathak Shruti , Mahajan Abhishek , Kumar Suman , Purandare Nilendu , Agarwal Archi , Puranik Ameya , Pendse Shantanu , Reddy Yallala Monica , Sahu Harsh , Kapu Venkatesh , Dey Sayak , Choudhary Jatin , Krishna Madala Ravi , Shetty Alok , Karuvandan Naveen , Ravind Rahul , Rai Rahul , Jobanputra Kunal , Chaturvedi Pankaj , Pai Prathamesh S. , Chaukar Devendra , Nair Sudhir , Thiagarajan Shivakumar , Prabhash Kumar
Published: January 2023

PURPOSE

There is a lack of published literature on systemic therapeutic options in cisplatin-ineligible patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) undergoing chemoradiation. Docetaxel was assessed as a radiosensitizer in this situation.

METHODS

This was a randomized phase II/III study. Adult patients (age ≥ 18 years) with LAHNSCC planned for chemoradiation and an Eastern Cooperative Oncology Group performance status of 0-2 and who were cisplatin-ineligible were randomly assigned in 1:1 to either radiation alone or radiation with concurrent docetaxel 15 mg/m2 once weekly for a maximum of seven cycles. The primary end point was 2-year disease-free survival (DFS).

RESULTS

The study recruited 356 patients between July 2017 and May 2021. The 2-year DFS was 30.3% (95% CI, 23.6 to 37.4) versus 42% (95% CI, 34.6 to 49.2) in the RT and Docetaxel-RT arms, respectively (hazard ratio, 0.673; 95% CI, 0.521 to 0.868; P value = .002). The corresponding median overall survival (OS) was 15.3 months (95% CI, 13.1 to 22.0) and 25.5 months (95% CI, 17.6 to 32.5), respectively (log-rank P value = .035). The 2-year OS was 41.7% (95% CI, 34.1 to 49.1) versus 50.8% (95% CI, 43.1 to 58.1) in the RT and Docetaxel-RT arms, respectively (hazard ratio, 0.747; 95% CI, 0.569 to 0.980; P value = .035). There was a higher incidence of grade 3 or above mucositis (22.2% v 49.7%; P < .001), odynophagia (33.5% v 52.5%; P < .001), and dysphagia (33% v 49.7%; P = .002) with the addition of docetaxel.

CONCLUSION

The addition of docetaxel to radiation improved DFS and OS in cisplatin-ineligible patients with LAHNSCC. [Media: see text]
Activation of PDGF Signaling in the Adult Muscle Stem Cell Niche in Patients With Type 2 Diabetes Mellitus
Authors: Fahrner Alexandra , Alchus Laiferová Nikoleta , Ukropcová Barbara , Ukropec Jozef , Krützfeldt Jan
Published: January 2023

Context

Type 2 diabetes mellitus (T2D) negatively affects muscle mass and function throughout life. Whether adult muscle stem cells contribute to the decrease in muscle health is not clear and insights into the stem cell niche are difficult to obtain.

Objective

To establish the upstream signaling pathway of microRNA (miR)-501, a marker of activated myogenic progenitor cells, and interrogate this pathway in muscle biopsies from patients with T2D.

Methods

Analysis of primary muscle cell cultures from mice and 4 normoglycemic humans and muscle biopsies from 7 patients with T2D and 7 normoglycemic controls using gene expression, information on histone methylation, peptide screening, and promoter assays.

Results

miR-501 shares the promoter of its host gene, isoform 2 of chloride voltage-gated channel 5 (CLCN5-2), and miR-501 expression increases during muscle cell differentiation. We identify platelet-derived growth factor (PDGF) as an upstream regulator of CLCN5-2 and miR-501 via Janus kinase/signal transducer and activator of transcription. Skeletal muscle biopsies from patients with T2D revealed upregulation of PDGF (1.62-fold, P = .002), CLCN5-2 (2.85-fold, P = .03), and miR-501 (1.73-fold, P = .02) compared with normoglycemic controls. In addition, we observed a positive correlation of PDGF and miR-501 in human skeletal muscle (r = 0.542, P = .045, n = 14).

Conclusions

We conclude that paracrine signaling in the adult muscle stem cells niche is activated in T2D. Expression analysis of the PDGF–miR-501 signaling pathway could represent a powerful tool to classify patients in clinical trials that aim to improve muscle health and glucose homeostasis in patients with diabetes.
Hematopoietic Stem Cells and Metabolic Deterioration in Alström Syndrome, a Rare Genetic Model of the Metabolic Syndrome
Authors: Dassie Francesca , Albiero Mattia , Bettini Silvia , Cappellari Roberta , Milan Gabriella , Ciciliot Stefano , Naggert Jurgen K , Avogaro Angelo , Vettor Roberto , Maffei Pietro , Fadini Gian Paolo
Published: January 2023

Alström syndrome (AS) is a rare genetic disease caused by ALMS1 mutations, characterized by short stature, and vision and hearing loss. Patients with AS develop the metabolic syndrome, long-term organ complications, and die prematurely. We explored the association between AS and a shortage of hematopoietic stem/progenitor cells (HSPCs), which is linked to metabolic diseases and predicts diabetic complications. We included patients with AS at a national referral center. We measured HSPCs with flow cytometry at baseline and follow-up. We followed patients up to January 2022 for metabolic worsening and end-organ damage. We evaluated HSPC levels and mobilization as well as bone marrow histology in a murine model of AS. In 23 patients with AS, we found significantly lower circulating HSPCs than in healthy blood donors (−40%; P = .002) and age/sex-matched patients (−25%; P = .022). Longitudinally, HSPCs significantly declined by a further 20% in patients with AS over a median of 36 months (interquartile range 30-44). Patients with AS who displayed metabolic deterioration over 5.3 years had lower levels of HSPCs, both at baseline and at last observation, than those who did not deteriorate. Alms1-mutated mice were obese and insulin resistant and displayed significantly reduced circulating HSPCs, despite no overt hematological abnormality. Contrary to what was observed in diabetic mice, HSPC mobilization and bone marrow structure were unaffected. We found depletion of HSPCs in patients with AS, which was recapitulated in Alms1-mutated mice. Larger and longer studies will be needed to establish HSPCs shortage as a driver of metabolic deterioration leading to end-organ damage in AS.
Trade with Correlation
Authors: Lind Nelson , Ramondo Natalia
Published: January 2023

We develop a trade model with correlation in productivity across countries. The model spans the full class of generalized extreme value import demand systems and implies that countries with relatively dissimilar technology gain more from trade. In the context of a multisector trade model, we provide a tractable and flexible estimation procedure for correlation based on compressing highly disaggregate sectoral data into a few latent factors related to technology classes. We estimate significant heterogeneity in correlation across sectors and countries, which leads to quantitative predictions that are significantly different from estimates of models assuming independent productivity across sectors or countries. (JEL C38, F11, F13, F14, L16, O30)
Technological Change and the Consequences of Job Loss
Authors: Braxton J. Carter , Taska Bledi
Published: January 2023

We examine the role of technological change in explaining the large and persistent decline in earnings following job loss. Using detailed skill requirements from the near universe of online vacancies, we estimate technological change by occupation and find that technological change accounts for 45 percent of the decline in earnings after job loss. Technological change lowers earnings after job loss by requiring workers to have new skills to perform newly created jobs in their prior occupation. When workers lack the required skills, they move to occupations where their skills are still employable but are paid a lower wage. (JEL J24, J31, J63, O33)
Constrained-Efficient Capital Reallocation
Authors: Lanteri Andrea , Rampini Adriano A.
Published: January 2023

We characterize efficiency in an equilibrium model of investment and capital reallocation with heterogeneous firms facing collateral constraints. The model features two types of pecuniary externalities: collateral externalities, because the resale price of capital affects collateral constraints, and distributive externalities, because buyers of old capital are more financially constrained than sellers, consistent with empirical evidence. We prove that the stationary equilibrium price of old capital is inefficiently high because the distributive externality exceeds the collateral externality, by a factor of two when we calibrate the model. New investment reduces the future price of old capital, providing a rationale for new-investment subsidies. (JEL D21, D24, D25, D62, E22, G31, G32)
The Voice of Monetary Policy
Authors: Gorodnichenko Yuriy , Pham Tho , Talavera Oleksandr
Published: January 2023

We develop a deep learning model to detect emotions embedded in press conferences after the Federal Open Market Committee meetings and examine the influence of the detected emotions on financial markets. We find that, after controlling for the Federal Reserve’s actions and the sentiment in policy texts, a positive tone in the voices of Federal Reserve chairs leads to significant increases in share prices. Other financial variables also respond to vocal cues from the chairs. Hence, how policy messages are communicated can move the financial market. Our results provide implications for improving the effectiveness of central bank communications. (JEL D83, E31, E44, E52, E58, F31, G14)
Investment decisions and macroeconomic uncertainty
Authors: Πρίντζης Παναγιώτης
Published: January 2023

Εξετάζουμε την επίδραση της αβεβαιότητας στις επενδύσεις και στην κερδοφορία της ελληνικής επιχείρησης χρησιμοποιώντας δεδομένα ισολογισμών από 25000 ελληνικές επιχειρήσεις για ένα χρονικό ορίζοντα 14 ετών καλύπτοντας την περίοδο πριν και μετά την κρίση στην ευρωζώνη. Για την δημιουργία ενός δείκτη και μέτρου της αβεβαιότητας χρησιμοποιείται ένα μοντέλο dynamic factor. Αποδεικνύουμε την επιρροή της αβεβαιότητας στις επιχειρηματικές αποφάσεις μέσα από ένα δυναμικό μοντέλο ανάλυσης καθώς και μέσα από αναλύσεις με τη μέθοδο panel quantile regression. Τα αποτελέσματα δείχνουν ότι η επίδραση της αβεβαιότητας στις επιχειρηματικές αποφάσεις είναι αρνητική. Παρ’ όλα αυτά, η αρνητική επίδραση εξαρτάται από το μέγεθος της επιχείρησης και το ποσοστημόριο στο οποίο κατηγοριοποιείται. Και τα δύο μοντέλα ανάλυσης αποδεικνύουν το μεγάλο βαθμό ετερογένειας ανάμεσα στους κλάδους οικονομικής δραστηριότητας στην Ελλάδα.
Ζητήματα της μη-απόκρισης: Μεγαλύτερη «κάλυψη» του δείγματος ή ικανοποίηση των κριτηρίων συγκρισιμότητας στη συλλογή των δεδομένων;
Authors: Τσουπαροπούλου Εύα
Published: January 2023

Το ζήτημα της μη-απόκρισης θα απασχολεί τους κοινωνικούς επιστήμονες όσο οι δείκτες απόκρισης μειώνονται ραγδαία. Η αύξηση του αριθμού των επαναληπτικών επισκέψεων χρησιμοποιείται ως πρακτική αντιμετώπισης αυτού του ζητήματος. Η παρούσα μελέτη εξετάζει την αποτελεσματικότητα των επαναληπτικών επισκέψεων μετά από άρνηση του ερωτώμενου για τις 36 συμμετέχουσες χώρες στην Ευρωπαϊκή Κοινωνική Έρευνα (European Social Survey, ESS) και τους οκτώ γύρους διεξαγωγής της (2002-2016). Επίσης, ελέγχεται η εναρμόνιση (ή μη) όλων των χωρών με τους εκάστοτε σχετικούς μεθοδολογικούς κανόνες για τη θεμελίωση της συγκρισιμότητας των δεδομένων διαχρονικά. Τα αποτελέσματα της μελέτης επιβεβαιώνουν το μέγεθος του προβλήματος της μη-απόκρισης στην κοινωνική έρευνα και την αδυναμία των χωρών που συμμετέχουν στην ESS να εφαρμόσουν τις αυστηρές μεθοδολογικές προδιαγραφές.
Investigation of some acute phase proteins, cytokines and hepcidin values in feline enteric corona virus antibodies and feline infectious peritonitis antigen positive cats
Authors: Şahinduran Ş , Albay MK , Karaca M , Karakurum MÇ , Kiyici R
Published: January 2023

Feline Infectious Peritonitis (FIP) is a fatal disease caused by feline coronaviruses. The causative agent is Feline Infectious Peritonitis Virus, a mutation of Feline Enteric Coronavirus. Feline Corona Virus is very common in the cat population. In Feline Corona Virus infected cats, the development of FIP depends on the cat's immune response. FIP disease is more common in young and old cats because young and old animals have a weaker immune system. The acute phase response is a complex systemic reaction that occurs as a response to acute or chronic inflammatory processes such as infection, neoplasia or immunological disorders, tissue damage, trauma and surgery. The study material included 15 cat with presumptive FIP (study group) and 10 healthy cats (control group). Of the 15 cats, 9 (60%) showed dry and 6 (40%) effusive form. Serum amyloid A (SAA), haptoglobin (Hp),  α1-acid glycoprotein (AGP), albumin, interleukin-6 (IL-6), hepcidin, alanine-amino transferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), blood urea nitrogen(BUN), and creatinine levels were measured in the serum collected from both groups. There were no difference between the wet and dry FIP in albumin values; haptoglobin, α1-acid glycoprotein, SAA and hepcidin values were significantly different between the two groups. IL-6, showed significant difference in both wet and dry FIP groups. It was also concluded that hepcidin may be used as a biomarker in Feline Infectious Peritonitis disease like other acute phase proteins.
Effects of FSH Administered in Different ways on Superovulation Response and Blood FSH Levels in Cows
Authors: Çizmeci SÜ , Dinç AD , Güler M , Alkan H , Kıvrak MB , Takcı A , Çiftçi MF , Yeşilkaya ÖF , Bulut P , Bulut S , Zhunushova A
Published: January 2023

Bu çalışmada adjuvan kullanılarak tek doz Subkutan (SC) FSH uygulamasının ve adjuvan kullanılmadan tek doz epidural FSH uygulamasının kan FSH düzeyleri ve süperovülasyon yanıtı üzerine etkilerinin belirlenmesi amaçlanmıştır. Holştayn inekler (n:18) süperovülasyon prosedürü için üç gruba ayrıldı (n = 6). Gruptaki (İM) hayvanlara 4 gün süreyle 12 saat arayla İntramusculer (IM) azaltıcı FSH (Stimufol, 500 μg domuz FSH ve 100 μg domuz LH, Ulg FMV, Liège, Belçika) dozları verildi. (E) grubundaki hayvanlara epidural aralığa FSH (500 µg) verildi. (SC) grubundaki hayvanlara, 10 mL Montanide ISA 206 adjuvanı içinde FSH eklenerek hazırlanan bir karışım Subkutan (SC) ile uygulandı. Overdeki CL sayısı ultrasonografik yöntemle ölçüldü ve 4 CL varlığına göre süperovülasyon belirlendi. FSH ölçümü için tüm hayvanlardan V. jugularis'ten kan örnekleri alındı. Serum FSH (pFSH) seviyeleri ELISA ile belirlendi. Grup 1'deki tüm hayvanlar, süperovülasyon prosedüründen sonra süperovülasyon tepkisine (4>CL) sahipti. 2. grupta sadece bir hayvan yanıt verdi. Grup 3'te, altı hayvandan dördü yanıt verdi. Kan örneklerinin FSH analizinden sonra, IM ve SC uygulamaları arasındaki fark istatistiksel olarak önemsiz iken, IM ve epidural uygulamalar arasındaki fark istatistiksel olarak anlamlıydı. SC ve epidural uygulamalar arasındaki fark önemsizdi.
Influences of dietary aspirin supplementation on growth performance, carcass characteristics and gastrointestinal organs of broilers
Authors: Tavakoli Masoomeh , Bouyeh Mehrdad , Seidavi Alireza
Published: January 2023

This study was performed to investigate the effect of dietary aspirin (A) on some performance traits in broilers using a completely randomized design, 120 one-day-old male broiler chicks Ross 308, three levels of aspirin (0, 50, and 100 mg/kg), in 4 replicates, each including 10 chicks, during 42 days. The effects of different levels of aspirin, added to a basal diet, on performance, carcass characteristics, and digestive organs of chicks were investigated. Data analysis was performed by SAS statistical software and the comparison of the means with Duncan's test. The results showed that the chickens fed by a diet containing 100 mg/kg of aspirin had the highest feed intake and weight gain and the best feed conversion ratio compared to the other treatments. Also, the lowest production cost and the best European factor were related to treatment A100 (P<0.05). In addition, the use of the same level of aspirin resulted in a significant increase in some carcass properties and a decrease in ventricular fat compared to the control (P<0.05). So, based on the results of the present study, the use of 100 mg/kg aspirin in the diet of broilers is recommendable to improve some performance parameters.
Study on the frequency and chemical composition of urinary stones of Moghani sheep in Northwest of Iran
Authors: Nozohour Y , Najarnezhad V
Published: January 2023

Nephrolithiasis is one of the most important urinary tract diseases of ruminants and a costly problem for many sheep and goat owners. Therefore, it is important to analyse the composition of renal stone to prevent the formation of these kind of stones. The aim of the present study was to determine the frequency and the chemical constituents of urinary stones of Moghani sheep in Northwest of Iran. The kidneys, ureters, and urinary bladders of 384 Moghani sheep were examined carefully. The prevalence of urinary stones was 3.7%. All the stones were in the pelvis of the kidney and no stones were found in the ureter or urinary bladder. Macroscopically, 85.7% of the urinary stones showed a rough (jagged) appearance and 12.3% of them a smooth appearance.  The largest and smallest urinary stones were 7 mm and 2 mm in diameter and 0.600 g and 0.087 g in weight, respectively. The composition of calculi were pure or mixed and included calcium oxalate (44.44%), magnesium ammonium phosphate (33.33%) and calcium carbonate (22.22%). Calcium oxalate was the major constituent in the urinary stone, hence, grazing on the pasture plants containing oxalate should be limited. More detail studies should be designed to clarify the contribution of environmental and nutritional factors in development of urinary stones.
Effects of Beta Vinasse Supplementation on Performance, Meat Quality and Ilio- Caecal Microflora in Quail Rations
Authors: Yeşilbağ DY , Cetin I , Cengiz SS , Cetin E , Sarpasar M
Published: January 2023

The aim of this study was to evaluate the effects of β-vinasse supplementation on the live weight (LW), live weight gain (LWG), feed intake (FI), feed conversion ratio (FCR), carcass yield, meat quality and ilio-caecal bacteriological flora of quails. A total of 240 5-d-old Japanese (Coturnix coturnix Japonica) quails, including both males and females, were divided into 3 groups 80 quails and treated as follow: a control group with 0 g β-vinasse/kg ration; (2) 15 g/kg β-vinasse and (3) 30 g/kg β-vinasse. The study lasted for 6 weeks. At the end of the experiment, suplementation with β-vinasse did not have significant effect on FI and FCR. Dietary supplementation with 30 g/kg β-vinasse significantly (P < 0.05)  increased LW (21 d) and LWG (5 to 21 d). The dietary treatment of quails with different levels of β- vinasse did not effect on hot carcass weight, cold carcass weights, hot and cold carcass yields and breast and thigh pH. The lightness (L*) and yellowness (b*) of breast values were significantly (P<0.05) increased of 30 g/kg supplementation. Different levels of β-vinasse significantly increased Lactobacillus spp. in faeces. As a result, it was concluded that β-vinasse (by-product obtained from molasses) can be used in quail diets as an alternative feed source that will meet the nutritional needs of the animal and have positive effects on the digestive system, especially on the intestinal health ( an increase in Lactobacillus spp. counts).
Border Disease In A Lamb: A Case Report
Authors: Akkaya F , Evci FZ , Küpeli ZA , Kandemir Ç , Taşkın T , Koşum N
Published: January 2023

In this case, it was aimed to report the clinical, hematological and pathological analysis results of a lamb born as infected with border disease virus (BDV). Severe central nervous system findings such as standing inability, continuous teeth grinding, muscle fasciculations in the head, ear and tail, hair loss around the eyes, lips and ears, abnormal appearance of the fleece, ataxia/rhythmic tremor and incoordination were detected in the case of lamb infected with BDV. The presence of BDV antibody and the levels of Triiodothyronine (T3) and Thyroxine (T4) were investigated in the serum samples for definite diagnosis. The tissue samples obtained from the brain and cerebellum were evaluated histopathologically and diagnosis of BDV was confirmed by necroscopic findings.
Determination of Direct and Indirect Effects on Milk Yield of Anatolian Buffaloes Using Path Analysis
Authors: Şahin A , Aksoy Y , Yildirim A , Ulutaş Z
Published: January 2023

This study aimed to determine the direct and indirect effects of the independent variables presented by the lactation lenght (LL), age of calving (CAGE), and daily milk yield (DMY) on the dependent variable of lactation milk yield (LMY) in Anatolian buffaloes. In this study, a total of 3761 LMY records of the 834 Anatolian buffaloes calving between 2012 and 2017 in Tokat province and around were used as the research material. In the study, the simple correlation coefficients between the dependent variable of LMY and independent variables were determined positive and significant (P<0.001). The research specified the direct determination coefficients of the independent variables of the LL, CAGE, and DMY on the dependent variable of LMY as 0.378, 0.004, and 0.350, respectively. The path coefficients related to LL, CAGE, and DMY were determined as 0.615, 0.021, and 0.592, respectively. Since the DMY and LL examined in the study had a high direct impact on the lactation milk yield, therefore it could be suggested that using these data as criteria in breeding programs conducted in the herds evaluated in the study will increase the success in the selections applied.
Determination of predictive factors for the clinical cure rate of endometritis in Holstein dairy cows
Authors: Hajibemani A , Mirzaei A
Published: January 2023

Endometritis is one of the most common disorders that negatively influence reproductive performance in dairy cows. The purpose of this study was to determine the predictive factors of the clinical cure of endometritis. A total of 700 Holstein dairy cows were examined for signs of clinical endometritis between 30 and 40 days in milk (the first examination in the time of clean test). A total of 131 cows with clinical endometritis were assigned for treatment. Cytological examination, reagent test strips, and characteristics of reproductive organs were evaluated at the time of treatment (the first examination) and two weeks after the treatment (the second examination: for evaluation of response to treatment of endometritis). After evaluation of treatment, cows were grouped into the responsive (n=56) and unresponsive (n=75) to treatment. Percentages of non-degenerated neutrophil (NDN), degenerated neutrophil (DN), total neutrophils and leukocyte esterase activity were significantly higher (P<0.05) in the unresponsive cows than those of responsive ones to treatment at the second examinations. Moreover, the nitrate test was significantly higher in the unresponsive group than the responsive group at the first examination. However, protein concentration and percentages of lymphocyte cells were significantly higher in the unresponsive animals than the responsive cows at the first and second stages of examination (P<0.05). Increasing of lymphocytes percentage, protein concentration, and nitrate test at the first stage of examination in the unresponsive cows showed more sever of inflammatory conditions and uterine infection in the unresponsive cows. Evaluation of these factors can predict the clinical cure of endometritis in dairy cows.
Pre- and post -exercise variation of blood parameters on performance endurance horses: a first race study from Algeria
Authors: Chikhaoui M , Fadhéla S , Belalia CZA , Ayad N
Published: January 2023

Abstract: This paper presents the first study conducted in Algeria to determine the pre and post-race hematological and biochemical parameters of horses of a 90 km endurance race for eliminated horses’ category and those who completed the races with good performance. This study was conducted on 15 endurance horses (10 Arabian Thoroughbred, 4 Arabian-Barb and 1 Barb). Nine (9) horses successfully completed the endurance race, whereas the other 6 were eliminated. Blood samples were collected from each animal before and after the end of the race. Whole blood samples were used for measuring the blood-biochemical parameters.  Our results showed a significant increase in the hematological parameters (RBC, HB, Ht and MCV), the total leucocyte count, neutrophils and platelets for the group of horses who finished the race successfully. A significant decrease was noticed for the lymphocytes and eosinophils numbers while serum biochemical parameters showed a significant increase of Ca, TG, urea, U-A, AST and CK and a decrease of Mg, CHE, GLU and ƔGT. This study showed that, for the eliminated horses, there were significant changes in values of the total leucocytic count, lymphocytes, neutrophils, HB and Ht as compared to good performance horses. Serum biochemical parameters showed a significant increase of TG, U-A, AST and CK and a significant decrease of Ca, Mg, CHE and ƔGT. Most of the hemato-biochemical parameters of both the eliminated horses and those who completed the race successfully depicted significant differences. The results of this study suggested that biochemical findings could help identify horses with an increased risk of developing metabolic alterations before their elimination during competitive endurance races of different distances. Therefore, proper management protocols, standard feeding and watering with proper preparation of animals before the race could prevent electrolytes imbalance and pathological affections during racing.
Distribution of Salmonella virulence factors originated from sheep and cattle in Algerian slaughterhouses
Authors: Nouichi S , Mezali L , Hamdi TM
Published: January 2023

The present study was carried out to determine the virulence gene profiles associated with Salmonella subsp. enterica strains recovered from cattle and sheep samples by polymerase chain reaction (PCR). A total of 84 Salmonella isolates belonging to 10 serovars were screened for presence of 8 different virulence genes (invA, pefA, sefA, pipB, sseC, ssaP, spvC and iroB) using their specific primers. Different distribution patterns of these genes were noticed amongst the isolates. While the iroB gene was the most identified (n= 65, 77.4%), the sefA gene was not detected in all tested strains. pefA and spvC genes were detected in S. Typhimurium only with a rate of 3.6%. The four other genes were found to be present in 61.9% each. Occurrence of virulence genes did not vary significantly (P> 0.05) by serovar or animal species, neither by type of sample. The presence of all screened genes was significantly associated with resistance to at least one antibiotic from different classes except quinolones. These results show that transmissible pathogenic Salmonella strains are circulating in slaughterhouses in Algeria.
(Semi)automated approaches to data extraction for systematic reviews and meta-analyses in social sciences: A living review protocol
Authors: Legate Amanda , Nimon Kim
Published: January 2023

Background: An abundance of rapidly accumulating scientific evidence presents novel opportunities for researchers and practitioners alike, yet such advantages are often overshadowed by resource demands associated with finding and aggregating a continually expanding body of scientific information. Across social science disciplines, the use of automation technologies for timely and accurate knowledge synthesis can enhance research translation value, better inform key policy development, and expand the current understanding of human interactions, organizations, and systems. Ongoing developments surrounding automation are highly concentrated in research for evidence-based medicine with limited evidence surrounding tools and techniques applied outside of the clinical research community. Our objective is to conduct a living systematic review of automated data extraction techniques supporting systematic reviews and meta-analyses in the social sciences. The aim of this study is to extend the automation knowledge base by synthesizing current trends in the application of extraction technologies of key data elements of interest for social scientists.

Methods: The proposed study is a living systematic review employing a partial replication framework based on extant literature surrounding automation of data extraction for systematic reviews and meta-analyses. Protocol development, base review, and updates follow PRISMA standards for reporting systematic reviews. This protocol is preregistered in OSF: (Semi)Automated Approaches to Data Extraction for Systematic Reviews and Meta-Analyses in Social Sciences: A Living Review Protocol on August 14, 2022.

Conclusions: Anticipated outcomes of this study include: (a) generate insights supporting advancement in transferring existing reliable methods to social science research; (b) provide a foundation for protocol development leading to enhancement of comparability and benchmarking standards across disciplines; and (c) uncover exigencies that spur continued value-adding innovation and interdisciplinary collaboration for the benefit of the collective systematic review community.
Relationships Between Childhood Bullying/Domestic Violence Experience and Insomnia among Employees in Japan
Authors: Muroi Kei , Ishitsuka Mami , Hori Daisuke , Takahashi Tsukasa , Ikeda Tomohiko , Saito Tamaki , Shinichiro Sasahara , Matsuzaki Ichiyo
Published: January 2023

Traumatic childhood experiences such as domestic violence and bullying have been reported to be associated with insomnia in adulthood. However, little evidence is available for the long-term effects of childhood adversity on workers’ insomnia worldwide. Our objective was to examine whether childhood experiences of bullying and domestic violence are associated with insomnia in workers in adulthood. We used survey data from a cross-sectional study of the Tsukuba Science City Network in Tsukuba City, Japan. Workers aged 20 to 65 years (4509 men and 2666 women) were targeted. The Binomial Logistic regression analysis with the Athens Insomnia Scale as the objective variable showed that childhood bullying and domestic violence experience of childhood bullying and domestic violence were associated with insomnia. It may be useful to focus on childhood traumatic experiences regarding insomnia in workers.
Physiological characteristics of IRR 400 series rubber clones (Hevea brasiliensis Muell. Arg.) on drought stress
Authors: Pasaribu Syarifah Aini , Basyuni Mohammad , Purba Edison , Hasanah Yaya
Published: January 2023

Background: Drought stress is one of the main causes of plant death. Strategies for plants survival are morphological adaptations, specific signaling pathways, and tolerance mechanisms. Rubber plantations have many uses, such as foreign exchange sources, job sources, forest revitalization, and a source of alternative wood for building materials and furniture. The rubber plant’s response to drought stress is a complex biological process. A tolerant rubber clone in a dry area is the right approach. The present study aimed to determine the mechanism of drought-tolerant clones, based on physiological characteristics, to obtain character selection and drought-tolerant clones early.

Methods: The first factor examined for this work was clones (IRR 425, IRR 428, IRR 429, IRR 434, IRR 440, RRIC 100, and BPM 24) and the second factor was water content (30%, 60%, and 90%). The study was arranged on a factorial randomized block design and repeated three times. Characteristics observed were total sugar (µM), proline (mg/L), chlorophyll a, b, total (µg/mL), hydrogen peroxidase (µmol/g), ascorbate peroxidase (unit/mg), superoxide dismutase (unit/mg), and peroxide dismutase (unit/mg).

Results: The tolerance ability of the IRR 400 series rubber clones to drought stress was determined by observing the characteristics of sugar total and proline. The concentration of total sugar and proline were higher when the plant was treated with a lower water content. The selected clones tolerant to drought stress are RR 425 and IR 434 with high total sugar content and proline. Other characteristics, namely chlorophyll a, b, and total, as well as hydrogen peroxidase, ascorbate peroxidase, super oxide dismutase, peroxide dismutase, cannot be used as selection characteristics for this study.

Conclusions: This drought study of IRR 400 clones with varying water content percentages illustrated that the total sugar and proline characteristics could be used to distinguish tolerance levels from other observed characteristics.
Modeling document labels using Latent Dirichlet allocation for archived documents in Integrated Quality Assurance System (IQAS)
Authors: Prianes Freddie , Palaoag Thelma
Published: January 2023

Background: As part of the transition of every higher education institution into an intelligent campus here in the Philippines, the Commission of Higher Education has launched a program for the development of smart campuses for state universities and colleges to improve operational efficiency in the country. With regards to the commitment of Camarines Sur Polytechnic Colleges in improving the accreditation operation and to resolve the evident problems in the accreditation process, the researchers propose this study as part of an Integrated Quality Assurance System that aims to develop an intelligent model that will be used in categorizing and automating tagging of archived documents used during accreditation.

Methods: As a guide in modeling the study, the researchers use an agile method as it promotes flexibility, speed, and, most importantly, continuous improvement in developing, testing, documenting, and even after delivery of the software. This method helped the researchers in designing the prototype with the implementation of the said model to aid the process in file searching and label tagging. Moreover, a computational analysis is also included to further understand the result from the devised model.

Results: As a result, from the processed sample corpus, the document labels are faculty, activities, library, research, and materials. The labels generated are based on the total relative frequencies which are 0.009884, 0.008825, 0.007413, 0.007413, 0.006354, respectively, that have been computed between the ratio on how many times the term was used in the document and the total word count of the whole document.

Conclusions: The devised model and prototype support the organization in file storing and categorization of accreditation documents. Through this, it is easier to retrieve and classify the data, which is the main problem for the task group. Further, other patterns in clustering, modeling, and text classification can be integrated in the prototype.
Church Slavonic vъskopysnǫti and zaskopivъ / zaskopije
Authors: Boček Vít
Published: January 2023

In the present paper, the etymologies of two Church Slavonic words, namely of vъskopysnǫti and zaskopivъ/zaskopije are presented. Both their forms and their semantics are taken under scrutiny in order to revise the etymological explanations hitherto proposed. It is shown that both words most probably originate from the Indo-European root *(s)kep-/*(s)kop- ʻto chop, hew, dig, beatʼ.
Polish dictionaries of the Arabic language
Authors: Górska Elżbieta
Published: January 2023

The history of language and linguistics is based above all on material remnants and evidence contained in the literature of a given language. In this context the basic and crucial role is played by the true hoard of knowledge about this subject: dictionaries, lexica, thesauri and encyclopaedias. The development of the Arabic language and the stages of the interest in its particular layers may be traced to a great extent on the basis of the history of its lexicography. In the European context the achievements of Polish Arabists in this field remain almost unknown although they also contribute to the globally-conceived evolution of the Arabic language and are a part of its history. Therefore the author of this paper would like to present a collection of Polish dictionaries of the Arabic language, in an as comprehensive and up-to-date manner as possible, against the background of a brief outline of Arabic lexicographical thought, furnished with a concise commentary about both their content and the system of the arrangement of words. Presenting the philosophy of language that is favoured by the creators of dictionaries, the paper can be instructive for the potential users of the particular lexica. The author assumes that regardless of the ordering of information about the present state of the lexicographical achievements of Polish Arabists, it will perform the function of a sui generis guide to the resources associated with Arabic lexicography and phraseology which are available – both literary and dialectal ones – published in the Polish language. The systematic development of this kind of works indicates that there is a growing need of contact with the Arabic language, both at the basic level which enables simple communication and at the much more advanced, specialised level. The state of research in the field of Polish scholarship devoted to Arab studies in the 21st century clearly indicates a tendency to process dialectal vocabulary and phraseology that facilitates in a considerable way everyday communication in a given area whereas as far as the literary language is concerned, specialised lexica are developed that strive to take into account the issues associated with modernity – the dynamic growth of technology and globalisation. The general- purpose dictionaries of the literary language are become on-line resources, in the guise of an open formula that facilitates the running enhancement of the content with new lexemes and with new meanings of the existing ones that are attested by the context. It is also in this case that the root arrangement is no longer used – the enhancement of the resources of accessible knowledge at the expense of an in-depth analysis of structures and problems seems to be a sign of both modern times and modern Arabic lexicography.
Zu einigen strittigen Fragen der historischen Sprachwissenschaf
Authors: Jenő Kiss
Published: January 2023

The paper discusses some problems concerning the theory of linguistic change. It focuses on three interdependent issues: a) language and its user, b) language and its use, c) linguistic change und human conduct. Through a series of linked transmission, the law of homeostasis prevails in the human activity of language use as well. And given that linguistic change comes into being in the course of humans’ linguistic activity, that is, in language use, the author argues that homeostasis can be seen as a general mechanism indirectly governing language change.
Romanes dilinó ‘verrückt’ im Kontrast zu türk. deli ‘irrsinnig, verrückt, ungestüm’
Authors: Leschber Corinna
Published: January 2023

The etymology of the Romani (Gypsy language) word dilino, meaning ‘crazy’, can be traced back to its Indian roots; meanwhile, after showing its linguistic productivity, the word has resulted in a high number of derivatives in Romani dialects. Within surrounding languages, we can find numerous loans from the word family for the Romani dilino. In contrast to the Romani word with its Indian etymology, the Turkish word deli, also meaning ‘crazy’, has played an important role as a source for many words in the Balkan languages, particularly in Bulgarian and, to a smaller extent, in Romanian. It is possible that the semantic content of the Turkish deli has influenced the meaning of the Romani word to a certain extent. In Romanian, we can find homonyms, some of which can be explained with a Romani etymology, while others seem to be the result of a loan from Turkish or at least influenced by its semantic content. Overall, this requires a thorough analysis of these Romanian homonyms, each of which show a slightly different semantic content.
An Ottoman-Polish dictionary in the age of Wikimedia projects
Authors: Majtczak Tomasz
Published: January 2023

The article is an attempt to formulate some basic rules of compiling a modern electronic Ottoman dictionary that would both conform to the present-day standards of lexicography and would be easy to use for a relatively untrained reader at the same time. As an interface example, the Polish-language version of Wiktionary (i.e. Wikisłownik) is taken, which constitutes enormous technical facilitation for potential compilers. The description of the rules for the particular sections of an Ottoman entry in this lexicon, from pronunciation and inflexion through definitions and sentence examples up to etymology, is followed by two extended sample entries illustrating the discussed issues. This Ottoman- Polish Wikisłownik may become the first modern dictionary of these two languages, freely available online and quite easy to prepare.
Ujfalvy’s place in the development of Finno-Ugrian language studies in the second half of the 19th century in France
Authors: Piechnik Iwona
Published: January 2023

The article presents the work of Charles Eugène de Ujfalvy de Mező-Kövesd [Hung. Mezőkövesdi Ujfalvy Károly Jenő] (1842–1904), still less known French- Hungarian researcher, who played an important role as an initiatior of the Finno-Ugrian language studies in France. His interests were very wide and he worked hard with a real scientific passion. He left behind numerous publications on linguistics, anthropology and ethnography, which contributed to the increase of the general knowledge about Asia’s many peoples in the second half of the 19th century.
The Magnificent Five – the Latin fifth declension revisited
Authors: Piwowarczyk Dariusz R.
Published: January 2023

Chulym Turkic is still one of less known and researched Turkic languages. The situation is a little better in the case of its Middle Chulym dialect, several studies of which have been published in the last couple of years. Since the Küärik lexical material is included in Radloff’s dictionary, the poorest attested is the Lower Chulym lexical material: it still lays scattered in various works by Duĺzon, which are sometimes very difficult to obtain. We reproduce here the short text which was originally published in Duĺzon article from 1952 and offer its linguistic analysis and determine how correct Duĺzon’s translation is. The text is enteresting from both the linguistic and ethnographic point of view.
„How do they make bread?” – A philological commentary to a Lower Chulym text recorded by A.P. Duĺzon
Authors: Pomorska Marzanna
Published: January 2023

Chulym Turkic is still one of less known and researched Turkic languages. The situation is a little better in the case of its Middle Chulym dialect, several studies of which have been published in the last couple of years. Since the Küärik lexical material is included in Radloff’s dictionary, the poorest attested is the Lower Chulym lexical material: it still lays scattered in various works by Duĺzon, which are sometimes very difficult to obtain. We reproduce here the short text which was originally published in Duĺzon article from 1952 and offer its linguistic analysis and determine how correct Duĺzon’s translation is. The text is enteresting from both the linguistic and ethnographic point of view.
Linguistic typology and the Indo-European sigmatic future
Authors: Shields Kenneth
Published: January 2023

Based on the idea that linguistic typology may be used to devise etymological formulations not before recognized, this brief paper develops the proposal that the sigmatic future attested in some Indo-European dialects may ultimately derive from a grammaticalization and subsequent morphologization of *sed- ‘go’.
Perfection in Biblical Hebrew
Authors: Termińska Kamilla
Published: January 2023

The paper is an attempt to capture the particular properties of the notion of “perfection”, with regard to the classical language of the Tanach where as many as six highly polysemous roots refer to it. They constitute a typical, Wittgensteinian family of meanings connected in a refined way through familial similarity. There is no single, superior semantic criterion that would allow all of these six roots to occur in the same contexts, a shared sense characteristic for them and them only (a sufficient condition). There is also no conceptual indicator that would set the boundary between the senses of utterances constituted by these roots, and the senses of utterances in which they do not feature. Combined with a positive criterion, the semantic negative criterion (a necessary condition) is the reason why this entire family of meanings has an obviously open character, a fact which is confirmed by a detailed analysis of utterances constituted by formations generated by these six roots.
L’Isle de Cube ou l’Île de Cuba – note sur l’édition critique du texte et la langue d’Alexandre de Humboldt
Authors: Tylus Piotr
Published: January 2023

L’article contient certaines idées concernant les façons de procéder dans le cas de l’édition critique des écrits français d’Alexandre de Humboldt (1769–1859) – auteur allemand et auteur français par excellence, qui parfois rentre difficilement dans la norme linguistique de son temps, mais tout ce qui paraît être erreur à première vue, ne l’est pas. Comment l’éditer ? Corriger trop vite, à outrance, en posant un regard sévère, ainsi que l’on faisait dans les éditions allemandes d’autrefois, ou bien essayer de faire une distinction entre les solutions inhabituelles dues à la hâte et celles qui permettent de supposer un choix conscient de l’Auteur ? Humboldt archaïse souvent, de plus, il joue avec la langue et n’hésite pas à inventer, à créer, il pense la langue. Dans l’article il est question d’un cas particulier, celui du manuscrit d’Isle de Cube. Antilles en général, disponible dans une partie du patrimoine d’Alexandre de Humboldt, conservé dans le fonds « Berlinois » à la Bibliothèque Jagellonne de Cracovie. L’édition diplomatique et critique du texte, à l’établissement de laquelle P. Tylus a pris récemment une part active, vient de voir le jour (sur le site de l’Académie des Sciences de Berlin-Brandebourg).
Delabialization after *u and the distribution of labiovelars in dialectal Proto-Indo-European
Authors: Woodhouse Robert
Published: January 2023

Evidence is presented in support of a typologically based hypothesis of a prefinal stage of PIE in which palatovelars were opposed to a single set of phonemes, each phoneme comprising plain velar allophones and labiovelar allophones. During this stage delabialization of the labiovelar allophones took place in the environment after *u, the output being reinterpreted as palatovelars. The stage was terminated when one of the backvelar allophones – which one depending on the dialect – spread beyond its original environment(s) and became dominant in a specific set of dialects. The hypothesis thus contributes (1) a solution to the gutturalfrage that is not limited to inadequately motivated rejections of one or other of the three series of tectal phonemes on offer in the current mainstream reconstruction of PIE occlusives; (2) a rationale for the rise of labiovelars in PIE, (3) a coherent explanation for a currently unacknowledged source of gutturalwechsel, viz. delabialization after *u in satem languages and (4) motivation for the replacement of the awkward concept of “palatalization after *u” in Armenian by a straightforward delabialization.