bluuebunny/crossref_metadata_2025 huggingface dataset:
Transparency and its drivers. A study of the Colombian experience (2012-2016)
Authors: Castañeda-Rodríguez Víctor Mauricio , Leon-Silva Jeimi Maribel
Published: March 2024

Abstract The research aim is to analyze the drivers of transparency levels in Colombian municipalities from the perspective of citizens (agency theory) and local governments (legitimacy theory). We used the Panel Corrected Standard Errors (PCSE) and a system Generalized Method of Moments (GMM) estimator in a dataset of 1,101 Colombian municipalities for five years (2012-2016). Our results show that fiscal autonomy, education, gross domestic product per capita, population size, and political participation are positively associated with public information disclosure in Colombia. Through this research, we contribute to the transparency literature in subnational governments in developing countries by examining determinants related to “citizens’ monitoring abilities” and “pressures for legitimacy” in Colombia.
Liderança no processo de inovação colaborativa no setor público: uma revisão integrativa
Authors: Paschoiotto Waldemir Paulino , Cunha Cristiano José Castro de Almeida , Silva Solange Maria da
Published: March 2024

Resumo As sociedades contemporâneas, cada vez mais interconectadas, enfrentam problemas complexos que impactam a vida das pessoas e demandam soluções inovadoras, construídas de forma colaborativa. No setor público, os gestores têm demonstrado crescente interesse na colaboração para estimular o desenvolvimento e a implementação de soluções inovadoras. Apesar disso, o campo de pesquisas sobre o papel da liderança nesse processo ainda é incipiente. O objetivo deste trabalho é construir uma síntese da literatura sobre o papel dos líderes em processos de inovações colaborativas no setor público. Por meio da metodologia de revisão integrativa e análise temática, o objetivo foi identificar as lacunas e as possíveis conexões que venham a direcionar futuras pesquisas no campo. A geração de um mapa temático revela dois macrotemas - papéis e ações dos líderes - associados a seis temas: metagovernança, atuação tridimensional, observação dos requisitos básicos, reestruturação da organização, superação de obstáculos e exploração dos impulsionadores. Essa estrutura prescreve como os líderes públicos podem atuar ao se engajar no desenvolvimento de inovações colaborativas mais efetivas para a sociedade. A revisão evidencia ainda que é recomendável que o perfil dos líderes públicos indicado para estimular processos de inovações colaborativas seja proativo e menos apegado a formalismos, devendo observar uma atuação como metagovernante para convocar, orquestrar, facilitar, regular, mediar e catalisar os processos de inovação.
Access to fresh food in vulnerable urban areas: a classification study of the favelas and formal establishments in São Paulo
Authors: DUARTE ANDRÉ LUÍS DE CASTRO MOURA , RODRIGUES VINICIUS PICANÇO , ALVES RAQUEL CAROLINNE FREITAS , OLIVEIRA GUSTAVO MAGALHÃES DE
Published: March 2024

Abstract The environment significantly influences individuals’ food choices. Vulnerable urban areas, such as favelas, can have a decisive impact on discouraging the consumption of fresh, nutritionally rich foods. This issue is exacerbated by the urban infrastructure required to deliver fresh foods to these locations. Therefore, it is essential to understand the context of the favelas in the municipality of São Paulo in terms of the food environment and infrastructure to support the design of public policies that enhance the presence of minimally processed foods in these areas. We applied the k-means clustering method to two datasets: the food environment of favelas, characterized by food establishments, and the urban infrastructure of the favelas in the municipality of São Paulo. Of the city’s 1,701 favelas, only 271 have formally registered food establishments. Larger favelas with better urban infrastructure generally exhibited a food environment with greater access to fresh foods. The results suggest that investing in urban infrastructure can increase access to fresh foods in these areas. It is also necessary to consider local specificities to find effective solutions that increase the availability of minimally processed foods, thereby improving the population’s quality of life and health.
Dinâmica Política da Formulação da Política de Acesso à Informação no Brasil
Authors: Oliveira Júnior Temístocles Murilo de , Monteiro Cristiano Fonseca
Published: March 2024

Resumo A formulação da política de acesso à informação no Brasil é retratada como uma “história de sucesso”. Dados sobre a aderência da legislação brasileira aos padrões internacionais indica que suas instituições de acesso estão entre as dez primeiras na dimensão substantiva, mas são as últimas entre elas na dimensão processual. Que mecanismo conduziu esse processo para produzir tal ambivalência? Este estudo assume que a formulação da política de acesso no Brasil representou um processo ambíguo de emulação baseado em legitimidade, orientado para a homogeneização frente ao campo internacional, mas sem quebrar o controle governamental da informação. Este artigo se baseia em trabalhos teóricos sobre difusão de políticas com foco na emulação e aborda teorias sobre conflitos e negociação pelo poder como condutores da formulação de políticas. Os resultados sugerem que a dinâmica política de disputas e acomodação de interesses forjaram esse processo e seus resultados derivaram de trade-offs políticos entre atores-chave em questões controversas. Desta forma, materializaram as preferências dos atores não-governamentais por maior abrangência e nenhum “sigilo eterno”, mas também asseguraram a órgãos públicos as prerrogativas de implementação e decisão final sobre recursos. Este caso pode representar um fenômeno mais amplo, considerando que dados comparativos indicam que essa ambivalência na adesão entre as dimensões substantiva e processual da América Latina é maior do que em outras regiões.
Evidencias de validez de la escala Smoking Cessation Counseling - versión brasileña
Authors: Porreca Juliana Maria Ruoco Zambardi , Newhouse Robin Purdy , Santos Vinicius Batista , Lopes Juliana de Lima , Barros Alba Lúcia Bottura Leite de
Published: March 2024

Objetivo: evaluar las evidencias de validez de la estructura interna y de la confiabilidad de la versión brasileña del instrumento Smoking Cessation Counseling. Método: estudio psicométrico de análisis factorial confirmatorio y de confiabilidad realizado en 250 enfermeras de la práctica clínica. Para el análisis de la validez convergente del modelo factorial se calcularon valores de Average Variance Extracted, el análisis discriminante se realizó mediante el criterio de Fornell-Larcker. La confiabilidad se examinó por el coeficiente de alfa de Cronbach y por la confiabilidad compuesta. Resultados: fue necesaria la exclusión de siete ítems del dominio de Asesoramiento avanzado y un ítem del dominio Asesoramiento básico para obtener adecuadamente los valores de Average Variance Extracted y del criterio de Fornell-Larcker. La confiabilidad compuesta varió de 0,76 a 0,86 y el coeficiente de alfa de Cronbach global alcanzado fue de 0,86, variando de 0,53 a 0,84 dependiendo del dominio evaluado. Se obtuvo la versión final del instrumento compuesto de 16 ítems distribuidos en 4 dominios. Conclusión: la versión brasileña de Smoking Cessation Counseling obtuvo adecuadas evidencias psicométricas de validez y confiabilidad. Estudios posteriores serán necesarios para el refinamiento del instrumento.
Factores relacionados con la carga de trabajo de enfermería en la atención oncológica de mujeres hospitalizadas
Authors: Balaminut Talita , Godoy Gabriela Alves , Carmona Elenice Valentim , Dini Ariane Polidoro
Published: March 2024

Objetivo: evaluar la carga de trabajo de enfermería y los factores relacionados con la atención de mujeres hospitalizadas con cáncer ginecológico y de mama, según el Nursing Activities Scores adaptado para pacientes oncológicos. Método: estudio epidemiológico y transversal. Participaron mujeres con cáncer ginecológico y/o de mama, mayores de 18 años, hospitalizadas por un período mínimo de 24 horas. De las historias clínicas se recolectaron datos sociodemográficos y clínicos, Karnofsky Performance Status y carga de trabajo, según el Nursing Activity Score adaptado. Los factores relacionados con la carga de trabajo se analizaron mediante regresión lineal múltiple. Resultados: el puntaje promedio del Nursing Activity Scores fue del 29,3%, lo que indica que se brindan siete horas diarias de atención por paciente. Los factores relacionados con la carga de trabajo difirieron según diagnóstico de cáncer de mama o ginecológico (β=-0,01; p<0,001), tratamiento clínico o quirúrgico (β=-0,03; p<0,001) y capacidad funcional al momento del ingreso (β=0,07; p< 0,001), conforme a la escala Karnofsky Performance Status . Conclusión: hubo una mayor carga de trabajo en la atención a mujeres con cáncer ginecológico en tratamiento clínico y con menor capacidad funcional al momento del ingreso. Los hallazgos revelan información útil para optimizar recursos, mejorar procesos y flujos de trabajo, con el fin de promover un ambiente de trabajo favorable y una atención de calidad.
Factors related to Nursing workload in the Oncology assistance provided to hospitalized women
Authors: Balaminut Talita , Godoy Gabriela Alves , Carmona Elenice Valentim , Dini Ariane Polidoro
Published: March 2024

Objective: to evaluate the Nursing workload and its related factors in the assistance provided to hospitalized women with gynecological and breast cancers, according to the Nursing Activities Scores adapted for cancer patients. Method: a cross-sectional and epidemiological study. The participants were women with gynecological and/or breast cancer, over 18 years of age, and hospitalized for a minimum period of 24 hours. The following was collected from the medical records: sociodemographic and clinical data, Karnofsky Performance Status and workload, according to the adapted Nursing Activities Score. The factors related to workload were analyzed by means of multiple linear regression. Results: the mean Nursing Activities Scores was 29.3%, denoting seven hours of daily care per patient. The factors related to workload differed according to the breast or gynecological cancer diagnosis (β=-0.01; p<0.001), clinical or surgical treatment (β=-0.03; p<0.001) and functional capacity at admission (β=0.07; p<0.001), as per the Karnofsky Performance Status. Conclusion: there was greater workload for the care of women with gynecological cancer undergoing clinical treatment and with lower functional capacity at admission. The findings reveal directions for optimization of resources and improvements in work processes and flows, in order to promote a favorable work environment and good quality assistance.
Morphological and physiological properties of lupine nodule bacteria (Bradyrhizobium lupini) when grown on a typical urban soil
Authors: Seregina I. I. , Volobueva O. G. , Trukhachev V. I. , Belopukhov S. L. , Dmitrevskaya I. I. , Zhevnerov A. V.
Published: March 2024

Abstract In the conducted studies, the moorphological and physiological properties of nodule bacteria of lupine were studied. Lupine plants were grown under the conditions of a microfield experiment on a typical medium loamy urban soil. In the study, a pure culture of Bradyrhizobium lupini was isolated. Then, the morphological properties of nodule bacteria cells and the chemical composition of cell membranes of nodule bacteria were determined. The acid resistance and physiological properties of lupine nodule bacteria were also determined, as well as the ratio of Bradyrhizobium lupini to antibiotics. All studies were carried out according to generally accepted methods. The results of the research showed that during the cultivation of lupine on a typical urban soil, nodule bacteria Bradyrhizobium lupini were isolated, which can be characterized as gram-negative, non-spore-forming rods that do not exhibit amylolytic activity. It was revealed that the rhizobia of nodule bacteria are not acid-resistant. Nodule bacteria turned out to be the least resistant to polymyxin, then to levomycetin, and Bradyrhizobium lupini showed the greatest resistance to tetracycline.
Features of the choice of potato (Solanum tuberosum) varieties when growing two harvests in the temperate zone of Russia
Authors: Gasparyan I. N. , Levshin A. G. , Ivashova O. N. , Deniskina N. F. , Gasparyan Sh. V.
Published: March 2024

Abstract The development of potato plants during the cultivation of two crops occurs in a short period. At the same time, field conditions change and do not repeat over time. The formation of the crop during the cultivation of two crops in the Moscow region turns out to be in different growing conditions: the first crop falls on a long day and moderate temperatures, as well as sometimes returning frosts, the second crop falls on a short day and high temperatures, as well as a lack of moisture. The purpose of our research was to substantiate the choice of varieties for cultivation of two crops. Its solution is possible with a certain guaranteed efficiency based on the theory of statistical games. The research was carried out at the Vegetable Experimental Station of the Moscow State Agrarian University named after K.A. Timiryazev and at the Central Experimental Station of the Barybino Research Institute of Agrochemistry of the Moscow Region 2017-2022. The experiment was laid by the method of random placement of plots, the predecessor was a bow. The planting density is 47.6 thousand plants per 1 ha. Germinated tubers were used for planting during the first planting of a large fraction, during the second planting of an average fraction. The second landing was carried out on the vacant place after cleaning the first landing. The cultivation technology is standard. Cleaning was carried out in mid-July and at the end of September. Statistical game theory was used to determine the choice of a variety with a certain guaranteed efficiency. As a result of forecasting in critical climatic conditions, it is necessary to plant 1 crop - varieties Riviera and for 2 crops - varieties Luck.
Oral metformin for type-2 diabetes mellitus treatment in a black-tufted marmoset (Callithrix penicillata)
Authors: Duz Janyni , Surita Lívia E. , Machado Letícia , Costa Priscila M.D. , Machado Bruna S. , Valle Stella F. , Alievi Marcelo M. , Pöppl Álan G.
Published: March 2024

ABSTRACT: Type-2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and combined peripheral resistance to the hormone. Several non-human primates (NHP) species develop T2DM, mainly captive animals with reduced physical activity and incorrect feeding. This case report describes the T2DM treatment of a black-eared marmoset (Callithrix penicillata) by diet reformulation and metformin oral administration. An adult female was diagnosed with T2DM after hyperglycemia and high serum fructosamine associated with glycosuria and obesity. Metformin hydrochloride (125mg/animal, orally, q24h) associated with feeding intervention was started. After 26 days, a significant reduction in weight, glycemia, and serum fructosamine could be observed, showing satisfactory results for the adopted therapy. Metformin is considered a safe drug for T2DM treatment due to its low hypoglycemia risk. The new diet consisted of sweet potato, squash, and varied fruits offered twice daily. In addition, thawed-mice newborns, egg whites, and small portions of pelleted primate food. In the present report, metformin use, associated with a low glycemic index diet, was effective in treating this particular marmoset and may present a potential for T2DM treatment in other NHPs.
Cestrum axillare hepatotoxicity in cattle in the Distrito Federal, Goiás and Minas Gerais
Authors: Sousa Ana Lívia V. , Sousa Davi E.R. , Cerqueira Liz A. , Queiroz-Machado Cintia R.R. , Giaretta Paula R. , Riet-Correa Franklin , Castro Márcio B. , Machado Mizael
Published: March 2024

ABSTRACT: This study reports four outbreaks of Cestrum axillare poisoning in cattle. Outbreaks occurred in farms of the Distrito Federal, Goiás, and Minas Gerais states during the dry season, affecting cows and heifers, with a mortality rate of 1 to 14,28%. Poisoned animals showed neurological signs and recumbency, followed by death within 12 hours, and some animals were found dead. Gross and histological lesions were typical of acute hepatotoxicity with hepatomegaly, enhancement of lobular pattern, and centrilobular to massive necrosis. This study seems to be the first report on C. axillare poisoning in cattle in the Distrito Federal, Goiás, and Triângulo Mineiro. C. axillare poisoning must be included in the differential diagnosis for cattle with hepatic necrosis in these locations.
Agricultura familiar e programas de abastecimento de água no gerais do Alto-Médio rio São Francisco, Minas Gerais
Authors: Ribeiro Eduardo Magalhães , Galizoni Flávia Maria , Cruz Gildarly Costa da , Silva Keyty de Andrade
Published: March 2024

Resumo Durante quase três séculos o “gerais” do Alto-Médio rio São Francisco foi ocupado com sistemas de produção adaptados às chapadas, veredas e brejos. As tomadas de terras comuns, desmates e drenagens estimuladas pela “modernização agrícola” dos anos 1970 reduziram drasticamente as fontes e o acesso às águas, e então as secas passaram a afetar o abastecimento doméstico e produtivo. Este artigo analisa a travessia da “grande seca” de 2011/2019 em três comunidades do gerais, investigando programas públicos, abastecimento de água e produção agrícola na perspectiva da população rural. A metodologia foi referenciada na classificação local de agroambientes, usando grupos focais, entrevistas com lideranças comunitárias e famílias amostradas segundo diferentes composições. Conclui que o desaparecimento das condições históricas de acesso aos recursos levou a população a rearranjar a agricultura e o consumo de água. Vivendo novas situações, a lembrança da abundância de terras e águas é a inspiração para reivindicar, negociar e adequar programas públicos à cultura e às necessidades das comunidades.
Early-onset neonatal sepsis as a risk factor for peri-intraventricular hemorrhage in premature infants
Authors: Denicol Mariana Martins , Leotti Vanessa Bielefeldt , Soares Cátia Rejane Soares de , Hilgert Juliana Balbinot
Published: March 2024

ABSTRACT Objective: To assess early-onset sepsis as a risk factor of peri-intraventricular hemorrhage in premature infants born at less than or equal to 34 weeks’ gestation and admitted to a neonatal intensive care unit (NICU). Methods: This retrospective cohort study included premature patients born at less than or equal to 34 weeks’ gestation who were admitted to the NICU of a tertiary hospital in southern Brazil, and born from January 2017 to July 2021. Data were collected from patients’ medical records. Early-onset sepsis was measured according to the presence or absence of diagnosis within the first 72 hours of life, whereas the outcome, peri-intraventricular hemorrhage, was described as the presence or absence of hemorrhage, regardless of its grade. Results: Hazard ratios were calculated using Cox regression models. A total of 487 patients were included in the study, of which 169 (34.7%) had some degree of peri-intraventricular hemorrhage. Early-onset sepsis was present in 41.6% of the cases of peri-intraventricular hemorrhage, which revealed a significant association between these variables, with increased risk of the outcome in the presence of sepsis. In the final multivariate model, the hazard ratio for early-onset sepsis was 1.52 (95% confidence interval 1.01–2.27). Conclusion: Early-onset sepsis and the use of surfactants showed to increase the occurrence of the outcome in premature children born at less than or equal to 34 weeks’ gestation. Meanwhile, factors such as antenatal corticosteroids and gestational age closer to 34 weeks’ gestations were found to reduce the risk of peri-intraventricular hemorrhage.
Suicide attempts in the adult Mexican population: an analysis of sociodemographic characteristics and associated factors
Authors: Davila-Cervantes Claudio Alberto , Luna-Contreras Marisol
Published: March 2024

ABSTRACT Objective: Suicide is the culmination of a process or continuum known as suicidal behavior that proceeds from ideation and planning to attempt. The objective was to estimate the prevalence of suicide attempts in the adult Mexican population and to analyze their main associated factors. Methods: We conducted an observational, cross-sectional, and descriptive study with information from the National Health and Nutrition Survey (2018). Self-reported lifetime suicide attempt was used in the analysis. We analyzed depression, obesity, tobacco smoking, and alcohol consumption as suicide attempt-associated factors using a multivariate logistic regression model. Results: The prevalence of adult suicide attempt was 2.0% (95%CI 1.8–2.2) and it was higher among women (2.4%; 95%CI 2.2–2.8) and young people (2.9%; 95%CI 2.4–3.4). Low education (OR=1.6; 95%CI 1.2–2.2), being single (OR=1.3; 95%CI 1.0–1.6), having obesity (OR=1.4; 95%CI 1.1–1.8), consumption of alcohol (OR=2.4; 95%CI 1.7–3.4) or tobacco smoking (OR=1.8; 95%CI 1.4–2.4), and having strong symptoms of depression (OR=10.1; 95%CI 6.2–16.3) were associated with a higher prevalence of suicide attempts. Conclusion: These results help better understand suicidal behavior in Mexico and identify the factors that increase the likelihood of suicide attempts, which is essential to help reduce suicide mortality. This research is crucial for developing early interventions and prevention programs aimed at reducing suicide's public health burden.
COMPARISON OF GUT MICROBIOTA IN ALCOHOLIC AND METABOLIC-DYSFUNCION ASSOCIATED STEATOTIC LIVER DISEASE IN ANIMAL MODELS
Authors: PERLIN Cássio Marques , LONGO Larisse , THOEN Rutiane Ullmann , URIBE-CRUZ Carolina , ÁLVARES-DA-SILVA Mário Reis
Published: March 2024

ABSTRACT Background: Alcoholic liver disease (ALD) and metabolic-dysfunction associated steatotic liver disease (MASLD) are common, and gut microbiota (GM) is involved with both. Here we compared GM composition in animal models of MASLD and ALD to assess whether there are specific patterns for each disease. Methods: MASLD model- adult male Sprague Dawley rats, randomized into two groups: MASLD-control (n=10) fed a standard diet; MASLD-group (n=10) fed a high-fat-choline-deficient diet for 16 weeks. ALD model- adult male Wistar rats randomized: ALD-control (n=8) fed a standard diet and water+0.05% saccharin, ALD groups fed with sunflower seed and 10% ethanol+0.05% saccharin for 4 or 8 weeks (ALC4, n=8; ALC8, n=8). ALC4/8 on the last day received alcoholic binge (5g/kg of ethanol). Afterwards, animals were euthanized, and feces were collected for GM analysis. Results: Both experimental models induced typical histopathological features of the diseases. Alpha diversity was lower in MASLD compared with ALD (p<0.001), and structural pattern was different between them (P<0.001). Bacteroidetes (55.7%), Firmicutes (40.6%), and Proteobacteria (1.4%) were the most prevalent phyla in all samples, although differentially abundant among groups. ALC8 had a greater abundance of the phyla Cyanobacteria (5.3%) and Verrucomicrobiota (3.2%) in relation to the others. Differential abundance analysis identified Lactobacillaceae_unclassified, Lachnospiraceae_NK4A136_group, and Turicibacter associated with ALC4 and the Clostridia_UCG_014_ge and Gastranaerophilales_ge genera to ALC8. Conclusion: In this study, we demonstrated that the structural pattern of the GM differs significantly between MASLD and ALD models. Studies are needed to characterize the microbiota and metabolome in both clinical conditions to find new therapeutic strategies.
Migration and cancer mortality among Colombian migrants in the USA: a death certification study
Authors: Vries Esther de , Arroyave Ivan , Chayo Isaac , Pinheiro Paulo S.
Published: March 2024

Abstract We aim to compare cancer mortality rates of USA Colombian migrants (USA Colombians) to Colombians in their country of origin (CO Colombians). Using Colombian national mortality data and data on cancer deaths among Colombians residing in the states of California, Florida, and New York (USA Colombians) for the period 2008-2012, we estimated sex-specific and age-standardized mortality rates (ASMR), expressed per 100,000 persons. For comparisons between the two populations before and after adjustment for educational level, negative binomial regression models were used to compute Mortality Rate Ratios (MRR). CO Colombians had higher cancer mortality rates compared with USA Colombians (male MRR 1.4 [95%CI: 1.2-1.5], female MRR 1.5 [95%CI: 1.3-1.7]). These differences persisted for most cancers even after adjustment for education. CO Colombians had significantly higher mortality from gastric (MRR 2.6 in males and 2.8 in females) and cervical cancer (MRR 5.0) compared with US Colombians. Educational inequalities in cancer mortality were more pronounced among CO Colombians than among USA Colombians. Lower cancer mortality observed among USA Colombians cannot be attributed to differences in education, an indicator of socio-economic status. Rather, it is likely due to better access to preventive and curative healthcare in the USA.
Tacinga paiaia (Cactaceae), a New Species From the Semi-arid Region of Brazil
Authors: Freitas Juliana Gomes , Peraza-Flores Lizandro N. , Almeida Erton Mendonça de , Batista Fabiane Rabelo da Costa
Published: March 2024

Abstract— A new species of Tacinga from semi-arid Eastern Brazil, Tacinga paiaia, is here described on the basis of material collected several years ago and cultivated at the Cactarium Guimarães Duque of the Instituto Nacional do Semiárido.
A detailed description, original illustrations, distribution map, a taxonomic discussion for the new taxon, and a key to all known species of Tacinga are given. We also assessed the IUCN risk of extinction category for the new species. It is here preliminarily classified as Vulnerable
to extinction due to its small population size and restricted distribution. Finally, we also report the presence of extrafloral nectaries in the pericarpel areoles of the new taxon.
A New Endemic Smilax (Smilacaceae) from Tafelberg, Suriname, Supported by Morphometric and Phylogenetic Evidence
Authors: Murphy Thomas H. , Heaton Natalie M. , Molgo Iwan E. , Ho Kelly , Majure Lucas C.
Published: March 2024

Abstract— Taxonomy of Smilax in the Neotropics is poorly known with many undescribed species, unresolved synonymy, and regional treatments with conflicting taxon concepts. This issue is amplified in the Guiana Shield, which has arguably received the least amount
of taxonomic research in Smilax. Here, we investigate multiple specimens from Tafelberg, Suriname that we hypothesized to represent an undescribed species. We used univariate and multivariate morphometrics to analyze linear measurements and leaf outlines to test if and how Tafelberg
specimens differ from those of morphologically similar species in the Guiana Shield, Smilax lasseriana and S. maypurensis. We used a genome skimming approach to sequence and assemble plastomes, which also allowed us to extract plastid loci previously employed in Sanger-based
studies and place the putative new species in a phylogeny with expanded taxon sampling. We recovered the Smilax from Tafelberg as more closely related to species with ranges centered in eastern Brazil than to its morphologically hypothesized congeners, S. lasseriana and S.
maypurensis. We describe this new species as Smilax tafelbergensis with detailed morphological comparisons to similar taxa, a distribution map, and illustration.
A Principled Distributional Approach to Trajectory Similarity Measurement and its Application to Anomaly Detection
Authors: Wang Yufan , Wang Zijing , Ting Kai Ming , Shang Yuanyi
Published: March 2024

This paper aims to solve two enduring challenges in existing trajectory similarity measures: computational inefficiency and the absence of the ‘uniqueness’ property that should be guaranteed in a distance function: dist(X, Y ) = 0 if and only if X = Y , where X and Y are two trajectories. In this work, we present a novel approach utilizing a distributional kernel for trajectory representation and similarity measurement, based on the kernel mean embedding framework. It is the very first time a distributional kernel is used for trajectory representation and similarity measurement. Our method does not rely on point-to-point distances which are used in most existing distances for trajectories. Unlike prevalent learning and deep learning approaches, our method requires no learning. We show the generality of this new approach in anomalous trajectory and sub-trajectory detection. We identify that the distributional kernel has (i) a data-dependent property and the ‘uniqueness’ property which are the key factors that lead to its superior task-specific performance, and (ii) runtime orders of magnitude faster than existing distance measures.
NUMERICAL SIMULATIONS OF LIQUID FILM PRIMARY BREAKUP IN A PINTLE INJECTOR: A PARAMETRIC STUDY
Authors: Tang Tinglan , Jin Tai , Wang Gaofeng
Published: March 2024

In the present study, numerical simulations have been conducted to investigate the primary breakup
of the liquid film in the gas-liquid pintle injector, using the volume of fluid (VOF) method with
the adaptive mesh refinement to capture the gas-liquid interface. The film breakup and atomization
characteristics in the pintle injector are studied by changing the structure parameters and the momentum
ratio. The results show that increasing the radial liquid flow rate to raise the momentum
ratio promotes the atomization performance, while decreasing the axial gas flow rate deteriorates the
atomization performance. The two methods of altering the momentum ratio both cause the spray
angle to increase with the momentum ratio, but the first routine leads to a slower increase. With the
increase of opening distance, the velocity of the liquid flow decreases, and the thickness of the liquid
film increases significantly, making the film hard to break up. The skip distance negatively influences
the film breakup and atomization when the skip distance exceeds one. Moreover, the hollow region of
the spray is decreased with a longer skip distance, which is detrimental to fuel combustion.
RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting NLRP3 Ubiquitination in Liver Cancer
Authors: Liu Deqin , Luo Renyin , Zhou Qian , Li Mei
Published: March 2024

The present study explored that the effects and its possible mechanisms of ring finger protein 20 (RNF20) in Postoperative survival rate of liver cancer in clinical. All the serum samples were collected from our hospital. Quantitative polymerase chain reaction (PCR) and microarray analysis, and RNA pull down assay were used in this study. We found that the serum RNF20 mRNA expression level in patients with liver cancer were down-regulated. Postoperative survival rate of RNF20 high expression was higher than that of RNF20 low expression. Then, over-expression of RNF20 diminished liver cancer cell proliferation and metastasis. RNF20 reduced Warburg effect of liver cancer. RNF20 expression regulated NOD-like receptor protein 3 (NLRP3) expression and increased NLRP3 Ubiquitination. NLRP3 participated in the effects of RNF20 on cell proliferation, and not affected on Warburg effect of liver cancer. Our study demonstrated that the serum RNF20 expression level was down-regulated in liver cancer, and promoted postoperative survival rate. RNF20 can reduce cancer progression of liver cancer by NLRP3 signal pathway, suggesting that it may prove to be a potential therapeutic target for postoperative survival rate of liver cancer.
Median pelisäännöt. Sananvapauden toteutuminen oikeustapausten
ja toimitustyön eettisyyttä arvioivien Julkisen
sanan neuvoston ratkaisujen pohjalta
Authors: Kuutti Heikki
Published: March 2024

The online publication examines the implementation of freedom of speech and the requirements set for editorial work based on selected legal cases and the decisions of Council for Mass Media in Finland, which evaluates the ethics of journalism. The presentation aims to identify and illustrate" the problem areas of journalistic work by connecting the discussed case examples as part of the chronological editorial work process. Presentation starts from the external starting points of journalism (Journalism's operating environment), the general rights related to freedom of speech and access to information (The public's relationship with the media) and the journalistic decision-making power and independence of newsrooms, where we also look at possible abuses of media power (Journalism's credibility). The chapters following these parts deal with the time-sequenced practices of editorial work (Information acquisition, Story implementation, Publishing, and Follow-up journalistic activities).
"Efforts have been made to follow selected legal cases until their final, legally binding decisions" Some of the cases have been resolved in the national district court, court of appeal or supreme court proceedings, but some of these have progressed to the decision of the European Court of Human Rights, which interprets freedom of speech. The examples also include non-accusation settlements regarding the use of freedom of speech.

In the cases decided by the Council for Mass Media in Finland, features assessed as both unethical and meeting ethical requirements have been dealt with. In the examples, ethical interpretation of the considered part of the solution has been described, but the exempt-condemnatory marking that characterizes the conclusion as a whole has been removed.
The publication is based on the author's lecture courses on legal standards and ethics of journalism at the University of Jyväskylä and its partner institutions.
Russia’s Financial and Economic Policy in the Transition to a Multipolar World
Authors: Samarukha Victor
Published: March 2024

It is shown that the world is entering a new phase of geopolitical transformation, as quantitative measurements of the socio-economic development of the countries of South-East Asia (China and India), as well as Russia, have created objective prerequisites for the transition to multipolar, polycentric world development and the destruction of US hegemony. Under these conditions, the United States of America has strengthened its aggressive policy to restrain the processes of forming a new geo-economic architecture of the world, organizing the orange revolutions (in particular, in the spring of 2014 in Ukraine), political provocations and acts of aggression to destroy critical infrastructure (explosion of the Nord Stream international gas pipeline), and conduct proxy wars (including the nine-year war of neo-fascists in Ukraine against the DPR and LPR)as well as against countries pursuing sovereign policies that demonstrate compliance with the principles of international law. Upon that, the United States rallied around the NATO all the countries of the collective West against Russia, setting the task of destroying it as a state. The United States managed to bring neo-fascists to power in Ukraine and unleash a war against the Russian and Ukrainian peoples, which forced the Russian leadership to begin on February 24, 2022 the military-military organization for the demilitarization and denazification of Ukraine, as a result of which 4 regions of Ukraine returned to Russia. The article considers the formation of new world macrozones (including Russian) as new centers of a multipolar world, as well as a change in financial relations between countries, in the aspect of fair international trade and, accordingly, the destruction of the privileged value of the issue of US dollars.
SUMNJA U SUMNJU: KVORUMAŠKO PJESNIŠTVO U TREĆEM MILENIJU I ETOS SKEPTICIZMA
Authors: Vuković Tvrtko
Published: March 2024

Modernistička lirika oblikovana gestama rušilačke negativnosti, odbacivanja suparničkih poetika, uzdizanja vlastite intelektualne superiornosti te estetske, etičke i političke iznimnosti potiče etos sumnje i radikalnog kriticizma koji u današnje vrijeme pokazuje znakove onemoćalosti. Radom se zastupa teza da su pjesnici kvorumaškog naraštaja posljednjih dvadesetak godina u manjoj mjeri posvećeni skepticizmu, negaciji, denaturalizaciji, odbacivanju i demistifikaciji onoga što je navodno zastarjelo, okorjelo, disciplinirajuće, hegemonijsko ili lažno, a u većoj mjeri nastoje raznorodne poetike, teorijske ideje, diskurzivne strategije i svjetonazore okupljati, dovoditi u vezu, približavati, pridruživati kako bi oblikovali još nepostojeće, a obećavajuće svjetove. Politika je te lirike davanje, a ne oduzimanje glasa, sudjelovanje u svijetu, a ne elitističko isključivanje iz njega, gradnja, a ne razgradnja.
KRONİK RUHSAL BOZUKLUĞU OLAN HASTALARIN TIP DIŞI YARDIM ARAMA DAVRANIŞLARI VE İLAÇ UYUM DÜZEYLERİNİN BELİRLENMESİ
Authors: ŞİŞGİNOĞLU Esma Ceren , GÜNAY MOLU Nesibe
Published: March 2024

Amaç

Bu araştırma kronik ruhsal bozukluğu olan hastaların

tıp dışı yardım arama davranışları ve ilaç uyum düzeylerini

belirlemek amacıyla yapılmıştır.

Gereç ve Yöntem

Bu araştırma tanımlayıcı türde yapılmıştır. Araştırmanın

örneklemini Erzurum ilinde bulunan bir hastanenin

Psikiyatri Polikliniği’ne kronik ruhsal bozukluk tanısı ile

başvuran ya da başvurduğunda yeni tanı alan ve araştırmaya

katılmayı kabul eden 191 hasta oluşturmuştur.

Verilerin toplanmasında araştırmacı tarafından oluşturulan

Kişisel Bilgi Formu, Tıp Dışı Yardım Arama Davranışı

Bilgi Formu ve Tıbbi Tedaviye Uyum Oranı Ölçeği

(TTUOÖ) kullanılmıştır. Verilerin analizinde ki-kare

testi, T-testi, varyans analizi kullanılmıştır.

Bulgular

Araştırmamızda hastaların %79,6’sının tıp dışı yardım

aradığı, %86,4’ünün hastalık belirtileri ortaya çıkınca

ilk olarak hekime başvurduğu ve %73,3’ünün hekim

dışı başvurularda ilk başvurdukları kişinin dini unvanı

kullanan kişi (hoca) olduğu bulunmuştur. Hekim dışı

başvurulan yerde hastaya tanı koymak için uygulanan

yöntem %78,5 oranında dua ve muska olarak bulunmuştur.

Kronik ruhsal bozukluğu olan hastaların, cinsiyet,

yaş, medeni durum, yaşanılan yer, eğitim durumu,

çalışma durumu ve gelir düzeyi ile tıp dışı yardım arama

davranışlarının istatistiksel olarak anlamlı olduğu

belirlenmiştir. Kronik ruhsal bozukluğu olan hastaların-

Tıbbi Tedaviye Uyum Oranı Ölçeği puan ortalamasının

14,61±2,39 olduğu saptanmıştır.

Sonuç

Kronik ruhsal bozukluğu olan hastaların tıp dışı yardım

arama davranışları ilaç uyum düzeylerini olumsuz etkilemektedir.

Bu sonuç doğrultusunda psikiyatri hemşirelerinin

ilaç uyumu konusunda eğitici rolde olması,

hastaların bilgi birikimlerini arttırmaya ve aynı zamanda

tıp dışı yardım arama davranışlarını değerlendirmeye

yönelik girişimlerde bulunması önerilebilir.
RADIOLOGICAL ASSESSMENT OF THE PREVALENCE AND LOCATION OF ROOT RESORPTION IN EPILEPTIC PATIENTS: AN OBSERVATIONAL STUDY
Authors: TEMUR Katibe Tuğçe , PERTEK HATİPOĞLU Fatma , MAĞAT Güldane
Published: March 2024

Objective: Antiepileptic drugs used in the treatment of epilepsy patients have a negative effect on bone tissue, but as far as we know, tooth root resorption has not been investigated in these patients. The aim of this study was to evaluate the prevalence of external and internal root resorption and its distribution according to resorption sites in epilepsy patients using antiepileptic drugs.

Material and Methods: Panoramic radiographs obtained before dental treatment were evaluated. While the case group consisted of only those with epilepsy, the control group included healthy subjects. The presence/absence of external and internal resorption of all teeth (except the third molars), region of resorption (cervical, middle, and apical region of the root), age, and sex were recorded in an excel file. Independent sample t-test or Mann-Whitney U test according to normality of distribution and a chi-square test to compare categorical variables were used.

Results: The resorption in 93 (21.9%) of 424 patients (236 healthy subjects and 188 epileptic patients), the groups did not significantly differ by the presence of external and internal resorption (p = 0.089 and 0.746). It was more common in those over 30 years and males (p = 0.018 and 0.013).

Conclusion: We concluded that the presence of resorption in epilepsy patients was not different from healthy subjects. However, in patients with epilepsy, resorption was mostly seen in the lower molars and middle 1/3 regions. Clinicians should consider our results when treating these patients.
GÖĞÜS HASTALIKLARI VE GÖĞÜS CERRAHİSİ HEKİMLERİNİN AYDINLATILMIŞ ONAM KAVRAMI HAKKINDAKİ BİLGİ DÜZEYLERİNİN BELİRLENMESİ
Authors: CENGER Cüneyt Destan , ŞENBAŞ Zarif Asucan , KOLCU Giray , ERDOĞU Volkan
Published: March 2024

Amaç

Aydınlatılmış onam, ayırt etme gücüne ve davranışlarının

hukuki sonuçlarını değerlendirme yeteneğine

sahip olan hastanın, uygulanacak işlem ve tedavi

hakkında karar verebilmesi için hekim tarafından bilgilendirilerek

sözlü ve yazılı olarak alınan izindir. Bu

çalışmada Göğüs Hastalıkları ve Göğüs Cerrahisi hekimlerinin

aydınlatılmış onam hakkındaki bilgi düzeylerinin

belirlenmesi amaçlanmaktadır.

Gereç ve Yöntem

Araştırmacılar tarafından hazırlanan “Aydınlatılmış

Onam Bilgi Düzeyi Anketi” yüz yüze görüşme tekniğiyle

Şubat-Mayıs 2020 tarihleri arasında, hastanede

çalışan Göğüs Hastalıkları ve Göğüs Cerrahisi hekimlerine

uygulanmıştır.

Bulgular

Anket 84 hekime uygulanmıştır. Katılımcıların %69’u

kadın, %71,4’ü göğüs hastalıkları, %28,6’sı göğüs cerrahisi

hekimi, yaş ortalaması ise 36,93±11,58 yıl olarak

belirlenmiştir. Katılımcıların %71,4’ünün üniversite

eğitimi sırasında veya sonrasında aydınlatılmış onam

hakkında eğitim aldığı, %97,6’sının çalıştığı bölümde

aydınlatılmış onam formu bulunduğu tespit edilmiştir.

Hekimlerin %92,9’u hastaya aydınlatılmış onam formu

imzalatmanın kendilerini malpraktis davalarından

koruyacağını düşünmektedir. Aydınlatılmış onam bilgi

düzeyinin ortalama 70,46±9,09 (min:50-max:85) olduğu

belirlenirken, statü, branş, hekimlikte ve branşta

çalışma süresi, aydınlatılmış onam konusunda eğitim

alan ve almayan hekimler arasında aydınlatılmış

onam bilgi düzeyi arasında istatistiksel olarak anlamlı

ilişki olmadığı (p>0,05) saptanmıştır.

Sonuç

Çalışma sonucunda; hekimlerin aydınlatılmış onam

uygulamasının kendilerini malpraktis davalarından

koruyacağını düşündükleri, onam alma ile ilgili uygulamanın

yaygınlaştığı ancak hekimlerin onam konusunda

eğitim alma ihtiyacı hissetmeye devam ettikleri

saptanmıştır. Aydınlatılmış onam bilgi düzeyi ile

çalışmada elde edilen parametreler arasında anlamlı

bir ilişki tespit edilmemiş olmakla birlikte, hekimlerin bu konuda devam eden eğitim ihtiyaçları da göz

önüne alınmalıdır. Aydınlatılmış onam bilgi düzeyine

etki eden faktörlerin daha iyi anlaşılabilmesi açısından

farklı hastaneler, farklı coğrafi bölgeler, farklı yaş

grupları ve statülere göre sınıflandırılmış geniş çaplı

bir anket yapılması önerilmektedir.
ALGILANAN HASTANE DEĞERİ VE HASTANE BAĞLILIĞI İLİŞKİSİNİN ARAŞTIRILMASI
Authors: ÇİFTÇİ KIRAÇ Fatma
Published: March 2024

Araştırmanın amacı üniversite hastanesine müracaat

eden hastalarda algılanan hastane değeri ve hastane

bağlılığı ilişkisinin araştırılmasıdır.

Gereç ve Yöntem

Araştırmada nicel araştırma deseni ve kolayda örneklem

yöntemi kullanılmıştır. Araştırmada veri toplama

aracı olarak Moliner (2006) tarafından geliştirilen

Türkçe geçerlilik ve güvenirlik çalışması Akbolat ve

Durmuş (2021) tarafından yapılan Hastane Algılanan

Değer ölçeği, Price ve Arnould (1999) tarafından geliştirilen

Türkçe geçerlilik ve güvenirlik çalışması Ünal

(2016) tarafından yapılan Hastane Bağlılığı ölçeği kullanılmıştır.

Hastane Algılanan Değer ölçeğinin Cronbach

Alpha değeri 0,921, Hastane Bağlılığı ölçeğinin

Cronbach Alpha değeri 0,732 olarak bulunmuştur.

Araştırmanın örneklemini, Kahramanmaraş’ta bir üniversite

hastanesinden ayaktan poliklinik hizmeti alan

hastalar oluşturmaktadır. Araştırma kapsamında 321

hastaya ulaşılmıştır. Veriler üzerinde tanımlayıcı istatistikler,

bağımsız gruplarda t-testi, varyans analizi ve

korelasyon analizleri yapılmıştır.

Bulgular

Araştırmadan elde edilen bulgular sonucunda evli

olan bireylerin hastane değer algıları bekâr olan bireylere

göre daha yüksek tespit edilmiştir. Kronik rahatsızlığı

olan ve sürekli ilaç kullanan bireylerin hastane

değer algıları, kronik rahatsızlığı olmayan ve sürekli

ilaç kullanmayanlara göre daha yüksek bulunmuştur.

Okuryazar olmayan katılımcıların hastane değer

algıları ilkokul, lise ve lisans mezunlarına göre daha

yüksek bulunmuştur. Hastanenin algılanan değerinde

parasal maliyetlerin önemli olduğu sonucuna ulaşılmıştır.

Parasal olmayan maliyetlerin ise algılanan

değerde etkisi düşük bulunmuştur. İşlevsel değer ve

hastane kuruluşunun algılanan değeri boyutlarının

hastane bağlılığı üzerine anlamlı düzeyde pozitif bir

etkisinin olduğu tespit edilmiştir.

Sonuç

Araştırmadan elde edilen sonuçlar neticesinde algılanan

hastane değeri arttıkça hastane bağlılığının da

arttığı sonucu elde edilmiştir.
CUT and RUN v1
Authors: not provided anita.adami
Published: March 2024

This protocols describe how to perform CUT&RUN on human brain tissue (frozen)
Applying Spinal Cord Organoids as a quantitative approach to study the mammalian Hedgehog Signaling v1
Authors: Holzner Markus , Di Minin Giulio
Published: March 2024

The Hedgehog (HH) pathway is crucial for embryonic development, and adult homeostasis. Its dysregulation is implicated in multiple diseases. Existing cellular models used to study HH signal regulation in mammals do not fully recapitulate the complexity of the pathway. Here we show that Spinal Cord Organoids (SCOs) can be applied to quantitively study the activity of the HH pathway. During SCO formation, the specification of different categories of neural progenitors (NPC) depends on the intensity of the HH signal, mirroring the process that occurs during neural tube development. By assessing the number of NPCs within these distinct subgroups, we are able to categorize and quantify the activation level of the HH pathway. SCOs represent an accessible and reliablein-vitrotool to quantify HH signaling and investigate the contribution of genetic and chemical cues in the HH pathway regulation.
Immunohistochemistry (neural organoids) v1
Authors: not provided anita.adami
Published: March 2024

This protocols describes how to perform immunohistochemistry on neural organoids
CRISPR gRNAs cloning v1
Authors: Adami Anita
Published: March 2024

This protocol details the procedure of CRISPR gRNAs cloning.
The Impact of Corporate Governance on Financial Performance of Private Commercial Banks in Bangladesh
Authors: Neogy Taposh Kumar , Rahman Md. Obaidur
Published: March 2024

Corporate governance is imperious to the banking sector's growth. The study aims to explore how corporate governance mechanisms impact certain aspects of financial performance. This study has taken five listed conventional PCBs with a five-year study period from 2016 to 2020 using the purposive sampling technique. The influence of various CG mechanisms on financial performance attributes has been investigated through the use of multiple regression analysis. The study findings demonstrate that equity ratio, log total assets, and log listing age out of eight variables have a significant influence on NPM and ROA, while the other five variables revealed insignificant influence. On the other hand, ROE was influenced by log total assets and log listing age, but insignificant influence was found in the remaining six variables. Moreover, log listing age revealed a significant impact on EPS, whereas an insignificant influence has been observed in the case of the remaining seven variables. The study recommended that corporate governance must be adequate and transparent for the sake of pertinent stakeholders in the banking sector.