bluuebunny/crossref_metadata_2025 huggingface dataset:
A CONCEPTUAL REVIEW ARTICLE ON TWAK W.S.R. SKIN
Authors:   Professor, Rachana Sharir, Ashwin Rural Ayurvedic Mahavidyalaya, Manchihill, Sangamner., Suresh Shimpi Jitendra , Jitendra Shimpi Anupama ,   Associate Professor, Kayachikitsa, Tilak Ayurveda Mahavidya, Pune.
Published: May 2023

In Ayurveda the word Twak or Charma is used for skin. Twak is referred to as due to the fact its miles that which covers the frame. This also suggests the moves of skin within the shape of pulsatility and responsiveness. Twak is the Updhatu of Mamsa. at some point of the formation of Garbha, differentiation of the layers of the skin takes region and is produced by means of all of the 3 Dosha, particularly through the Pitta Dosha. Charaka described Twacha because the Matruja Bhava (maternal issue) that is one of the six Bhava crucial in the development of foetus. Twak is Upadhatuof Mans Dhatu which paperwork the outer protecting of the frame and protects frame from outside factors such as heat, bloodless and many others. its far an important organ of the integumentary machine envelops underlying tissues and organs. Ayurveda point out the Twak as Sparshanaindrya. The layers of the Twak has been cited through extraordinary Acharyas, but the know-how of the each layer isnt always so much clear with respect to the layer stated inside the modern technology. Acharya explained the thickness of the Twak layers in as compared with the Vreehi grain and each layer has distinct thickness. concerning the formation of Twak, it was correlated with simile of formation of casein over milk. there may be a want to understand the extraordinary layer of Twak and pores and skin, their structural, useful & developmental interpretation to correlate in among them. Aims & Objectives: To review Twak from various Ayurvedic Samhita.To study and correlate twaksthara with layers of skin. Materials and methods: The literary resources for the existing have a look at was amassed by means of ayurvedic samhitaslike Charaka Samhita, Sushruta Samhita, AstangSangrah,Bhavprakasha&Sharangdharaetc. it will likely be correlated with the contemporary available books, literature, journals, web sites, and studies paper as according to correlate the possible layer of skin and its formation with the layer of the Twak and its formation process on the basis of classical information. Conclusion-The classical description regarding the Pramana of each TwakSthara has lacuna of evidence so, it can be the issue for similarly have a look at and have to be matched with the modern-day descriptions. The layer of the Twak corresponds with the layer of skin within the purposeful and structural element.
Relationship between Dating Violence and Mental Health of Young Victims and Perpetrators: A Systematic Review
Authors: Yanez-Peñúñuri Libia Yanelli , Rey-Anacona César Armando , Garcia-Estrada Linda Isis
Published: May 2023

The objective of this study was to systematize knowledge from studies of the relationship between dating violence and mental health of victims and perpetrators. A systematic review of articles published from 1981 to 2021, with a population aged 12 to 29 years and English, Spanish, French, and Portuguese as the publication languages, was performed. The search was carry out in seven information sources: EBSCO, PsycINFO, PUBMED, ProQuest, ScienceDirect, SCOPUS, and WOS. Of the 2925 articles that were found, 27 studies were included (10 of which were longitudinal). An impact of dating violence on the mental health of adolescent victims was detected, with depression as the most frequently triggered effect in young people,followed by anxiety, suicidal ideation, low self-esteem, and low emotional well-being. The results indicate the need to design, implement, and evaluate different alternatives for the prevention of DV. In addition, in longitudinal studies, physical, psychological, and sexual dating violence victimization is associated with depressive symptoms, post-traumatic stress, suicidal ideation, and anxiety. In perpetrators of psychological dating violence, it is related todepressive symptoms, anxiety, and hostility. The findings of the present study can contribute to the creation of future research programs for promoting healthy couple relationships among adolescents and young people.
Division and Combination of Right to Defense and Right to Benefit: Focusing on Right to Trial and Right to Vote
Authors:   European Constitutional Law Association, YI ZOON IL
Published: May 2023

The right to defense means the right to demand the omission or cessation of an act of external aggression by the state against the freedoms presupposed thereon. Depending on the type of freedom that is the premise of the right of defence, the state’s external aggression against it also differs in its type. An aggression against freedom of action appears as an aggression that hinders or deters the action; an aggression against freedom of state appears as an aggression that interferes with or intervenes in a certain state, in particular, an aggression against a legal status where a certain legal status is guaranteed appears as an aggression that deprives the legal status. Thus, the right to defense includes requesting the omission or suspension of the imposition of a legal obligation to hinder or deter a specific act, the legal involvement to interfere with or intervene in a specific state, and the legislation depriving a specific legal status. Unlike the right to defense, which can demand negative action from the state, the right to defense is distinct from the right to benefit, which can demand positive action from the state. The positive actions that can be demanded from the state according to these rights to benefit are essentially legislative, and according to the content of these legislations, the types of the right to benefit are classified into protection rights, procedural rights, and social rights. Restrictions on the right to defense that can demand negative actions are made in the form of positive actions, and restrictions on the right to benefit that can demand positive actions are made in the form of negative actions. Therefore, the principle of proportionality, which is a constitutional principle required for the restriction of constitutional rights, is embodied in the principle of prohibition of excessively abundance and the principle of prohibition of excessively deficiency according to the type of restriction on constitutional rights. Both the prohibition of excessively abundance and the prohibition of excessively deficiency contain four parts of the proportionality principle. And the principle of balance of legal interests, which is the core principle of the principle of proportionality, becomes the most essential partial principle while justifying restrictions on constitutional rights when applying the principle of prohibition of excessively abundance or the principle of prohibition of excessively deficiency.
A Study on Swiss Consociational Democracy: Focusing on the Resident Participation System
Authors:   European Constitutional Law Association, Bae Gun Yee
Published: May 2023

Consociational democracy was systemized by A. Lijphart in the early 20th century as a democratic model suggested as an alternative to limits of majority democracy that a winner takes all. A. Lijphart points out forming the largest government, recognition of mutual veto power, member proportional of the parliament and cabinet, and recognition of a minority of autonomous rights as prerequisites for consociational democracy. According to these elements, Switzerland is applicable to a consociational democratic state of the typical Bottom-up structure that completed present federalism based on decentralism which recognized equal rights regardless of the alliance size starting from the Old Swiss Confederacy in the 13th century. Especially, initiative and referendum done at the level of the 26 states and more than 2,000 Gemeindes can be the key resident participation system which checks the nation and local governments and enables sharing power through equal participation as the new opportunities that minority opinions are not excluded but included. Especially, because the initiative and referendum systems are linked together and play a role of controlling power and have the structure that they can be done regarding taxation, increases in budget, etc which have an important effect on local finance, they more accord with the idea of local self-government that the residents themselves are the main agents of the regions. And because they have the structure that oppositions to local councils' decisions can be done by initiative and referendum, they make the residents play an enough role as the final surveillant of local decisions. Because communications between residents and regions, among residents, and regions and the central government continue to be done in the initiative process, referendum, and general assembly of the residents and the preparation process in the resident participation system of the swiss style like this, the resident participation system in the Swiss consociational democracy is the most important element of discussion premised on conversations and communications. In comparison with this, because the Korean resident participation system has the structure that initiative and referendum are not mutually linked but separately operated, it's the structure synergy effects of participation cannot be created. And because important details from a position of the residents are mostly excluded from resident participation, it is the structure that it is hard for the residents to actively participate in them. In addition, in the structure that local councils examine and vote for ordinances proposed by the residents, the need for changing their roles to more active for resident participation is raised because they are not different from the existing committees' examination. If legal consideration like this is done, the resident participation system which has more expanded since 2021 can play a role of driving the development of Korean local self-government and democracy.
Development of a multi-layer cylindrical rotating electret generator with increased power densit
Authors: Lu Yongling , Wang Zhen , Zhu Xueqiong , Liu Ziquan , Xue Hai , Zhang Ziyang
Published: May 2023

Electrostatic electret generator has attracted a lot of attention in recent years, but their low power density cannot be ignored. Based on the existing research, this paper increases its power density from two aspects, including in-plane and in-space aspects. In the plane aspect, through simulation analysis, we can draw a conclusion that the output power can be increased effectively by using the bipolar charging method. From the perspective of space, the power density can be increased several times by connecting the output ends of the multi-layer generation structure. By integrating the method into the electrostatic electret generator, the power output can be effectively increased, which is suitable to the application of higher energy requirements in the specific field and a certain application prospect.
Synthesis of copper-doped indium zinc sulfide nanosheets for high efficiency photocatalytic hydrogen production
Authors: Chen Lei , Chen Zongwen
Published: May 2023

The excessive use of fossil energy has caused a series of environmental problems. Hydrogen is a green energy substitute for fossil energy, and photocatalytic hydrogen production is an effective means of hydrogen production. Indium zinc sulfide catalyst has great application prospect in the field of photocatalysis due to its advantages of high stability and visible light absorption. Based on this, Cu doped indium zinc sulfide nanosheets were prepared in this paper. Compared with pure indium zinc sulfide nanosheets, copper doped indium zinc sulfide nanosheets have better photocatalytic hydrogen production performance. The design and synthesis of photocatalytic hydrogen-producing catalyst has important guiding significance.
Study on vibration characteristics of badminton racket embedded in acoustic black hole structure
Authors: Li Yuqi , Jiao Renqiang , Zhang Beiping , Dong Bowen , Nguyen Vanliem , Li Aoya
Published: May 2023

According to the principle of acoustic black hole effect, a badminton racket design method of embedded one-dimensional acoustic black hole structure was proposed. Based on the finite element simulation analysis, the broadband vibration attenuation characteristics of one-dimensional acoustic black hole structure were studied. The results show that this structure can not only ensure the light quality of the system, but also achieve good vibration reduction effect. In the absence of damping, a small truncation can make the reflection coefficient increase rapidly, and the larger the truncation, the worse the vibration suppression effect. The combination form of one-dimensional acoustic black hole structure and damping material shows obvious formant suppression in the wide band range, and the larger the thickness of the damping layer and the closer the location of the damping layer to the tip, the more obvious the damping effect.
Evaluation of failure criteria for residual tensile strength of composite laminates with circular holes
Authors: Hu Botao , Chen Xiangming , Deng Fanchen , Sun Xiaobo
Published: May 2023

To evaluate the effect of circular holes on the mechanical properties of laminated composite plates with different sizes, static tensile destructive tests were carried out on four different types of composite laminated plates with different layups and aperture sizes. The experimental results showed that for the four types of layup, the strength of the specimens with a diameter of 6.35 mm decreased by 44.3 %, 51.3 %, 48.0 %, and 39.4 % compared to intact specimens, and the greater the proportion of 0° layup, the greater the strength decrease of the perforated specimens. Under the same layup, as the diameter of the circular hole increased, the tensile strength decreased rapidly with the constant ratio of diameter to width. Based on the experimental results, three commonly used models for predicting the residual strength of perforated laminated composite plates, including point stress criterion, average stress criterion, and stress field intensity method, were evaluated. The results showed that the average stress criterion had higher accuracy compared to the point stress criterion and the stress field intensity method.
HR digitization: The main directions of development and influencing factors
Authors:   HSE University, Tatevosian Stella A.
Published: May 2023

Digital technologies play an increasingly big role in all areas of life and are changing the processes and structures of organizations from different spheres fundamentally. Human resource management is currently one of the key organizational processes going through an active stage of development through digitization. With the consideration of the growing percentage of digital HR practices, the competencies of HR professionals, line managers, and employees are also undergoing changes. This study systematizes the results of research on HR digitization over the past two decades. Based on the literature review, the article discusses the main directions of HR digitization, factors influencing the implementation and usage of HR technologies, and the avenues for future research on this topic. Three main directions of HR digitization are outlined: the digitization of a person, digitization of work, and digitization of HR processes. The factors influencing the implementation and usage of HR technologies are divided into three blocks, namely, organizational, technical, and human. The areas of further research include the context in which digitization takes place, its processes, social and technical aspects, as well as the implications. The article can be of interest to researchers of this topic and organizations which undergo or plan digital transformation.
FUNCTIONAL STATE OF THE SKIN MICROCIRCULATION BED IN HEALTHY FEMALES IN THE CONDITION OF DRY IMMERSION
Authors:   Institute of Biomedical Problems of Russian Academy of Sciences, Moscow, Pashkova D.V. , Popova Yu.A. ,   Institute of Biomedical Problems of Russian Academy of Sciences, Moscow, Fedorovich А.А. ,   Institute of Biomedical Problems of Russian Academy of Sciences, Moscow
Published: May 2023

Functional state of skin microcirculation vessels was studied in female subjects during 3-d dry immersion (DI). Microcirculation was investigated on the forehead, shin, forearm, fingers and toes with the use of laser Doppler flowmetry (LDF) and computer based video capillaroscopy. LDF showed that DI induced local changes in the level of perfusion, largely due to an increased myogenic control of the microvascular tone. Video capillaroscopy detected an upward trend in the number of functioning capillaries after DI; dimensions of the pericapillary zone remained unchanged.
The Immunopathy of Alzheimer’s Disease: Innate or Adaptive?
Authors: Weaver Donald F.
Published: May 2023

Beyond the time-honoured targeting of protein misfolding and aggregation, Alzheimer’s disease needs new, innovative therapeutic directions. When exploring alternative druggable mechanisms, multifaceted in vitro and in vivo data demonstrate that immune system dysfunction is a pivotal driver of Alzheimer’s disease progression. In pursuing neuroimmunological targets, a major but often under-discussed consideration regards the issue of whether innate or adaptive immunity (or both) within the neuroimmune network should be the centre of focus when devising immunotherapeutic approaches to Alzheimer’s. This perspective article briefly reviews current data, concluding that while both innate and adaptive immunity contributes to the immunopathology of Alzheimer’s, the pro-inflammatory microglia and cytokines of innate immunity will provide higher yield targets with a greater likelihood of efficacy. Although it seems paradoxical to focus on a rapid, short-lived aspect of immunity when seeking approaches to a quintessentially chronic brain disease, accumulating evidence affords ample data to support the target-rich cascade of innate immunity for the development of much-needed new diagnostics and therapeutics.
Treatment of Peri-implant Diseases using Lasers: A Systematic Review
Authors: AlMarzooqi Amna Mohamed Abdulla , Ramachandra Srinivas Sulugodu , Kukreja Bhavna Jha , Reddy Sesha , Souza Jovita Lawrence D. , Abdelmagyd Hossam Abdelatty Eid
Published: May 2023

Background:

Adjuncts to mechanical debridement, including administration of systemically and locally delivered antimicrobials, are constantly evaluated to achieve additional benefits while treating peri-implantitis. However, the potential for the development of antimicrobial resistance limits their use. Evaluation of the use of lasers for the treatment of peri-implantitis has provided varying results.

Objective:

This study aimed to summarize the existing literature on the additional benefits of lasers as adjuncts to mechanical debridement while treating peri-implant diseases.

Methods:

Randomised clinical trials published in English till Sept 2022 in PubMed, Medline, and clinical trial registries using the MeSH terms “peri-implant diseases”, “peri-implant mucositis”, “peri-implantitis”, and “lasers”, were included in the study. Case reports, case series, longitudinal studies, and retrospective analysis were excluded.

Results:

A total of fifteen (n=15) randomised clinical trials pertaining to peri-implantitis and three (n=3) trials pertaining to peri-implant mucositis were assessed. The trials assessed the use of diode, Nd: YAG, Er:YAG, CO2 lasers, and photodynamic therapy as adjuncts in the treatment of peri-implant diseases.

Conclusion:

The existing evidence regarding the use of laser for peri-implant mucositis is inconclusive, whereas for peri-implantitis, the majority of the studies support the use of lasers. Future trials should utilize the 2018 classification of peri-implantitis, so that a comparison of trials based on the studied parameters would be more accurate.
A Network Medical Framework based on Inflammatory Genes to Identify Drug
Candidates for Abdominal Aortic Aneurysms
Authors: Wang Bing , Niu Xiaoyang
Published: May 2023

Background:

Clinically, abdominal aortic aneurysms (AAA) can be treated with surgical intervention, but there is currently no effective drug for the disease.

Methods:

This study analyzed the biomedical data of single-cell RNA sequencing (scRNA-seq), RNA-seq and the network medical data of drug-target interaction as well as protein-protein interaction to identify key targets and potential drug compounds of AAA.

Results:

Firstly, we identified 10 types of cells from AAA and nonaneurysmal control samples and screened monocyte, mast cell, smooth muscle cell and
327 genes showing significant differences between non-dilated PVATs and dilated PVATs. To further explore the association of three types of
cells in AAA, we screened the common DEGs associated with the three types of cells and then identified 10 potential therapeutic targets for AAA.
SLC2A3 and IER3 were the key targets that were the most closely related to immune score and significantly related to inflammatory pathways. We
then designed a network-based proximity measure to identify potential drugs targeting SLC2A3. Finally, with computer simulation, we found that
the compound with the highest affinity to SLC2A3 protein was DB08213, which was embedded into the SLC2A3 protein cavity and formed close
contact with various amino acid residues, and was stable during the 100-ns MD simulation.

Conclusions:

This study provided a computational framework for drug design and development. It revealed key targets and potential therapeutic drug compounds for AAA, which might contribute to the drug development for AAA.
Tuning green-to-red ratio of Ho3+ Activated YPO4 dual-mode luminescence through Yb3+ sensitized nano phosphors
Authors: Putta Venkata Nagendra Kumar , Bandi Sirisha , Koneru Girija Venkateswara , Kanuparthy Phani Raja
Published: May 2023

INTRODUCTION:

Yb3+/Ho3+co-doped YPO4 nano phosphors were synthesized by polyol route, which has both up-conversion (UC) and down-conversion (DC) characteristics and excellent luminescent properties. DC peaks were seen at ~460, ~550, and ~650 nm.

METHOD:

Switching at ~750 with 300 nm excitation, a very faint P-O charge-transfer (CT) band of the Ho3+ ion and a minute non-radiative resonant energy transfer were observed. We found that YPO4: Yb3+/Ho3+ is an up-converting (UC ) nano phosphor capable of large-scale generation and enhancement of luminescence with green and red emissions.RESULT: Under strong laser irradiation at 980 nm, the up-conversion emission spectrum shows obvious peaks expected for Ho3+ ions at ~550 and ~650 nm. This process produces high-quality nanocrystalline materials with sizes in the range of tens of nm. Considering the results obtained under excitation at 300nm, YPO4:Yb3+/Ho3+ yielded high quantum yield values

CONCLUSION:

This finding can be used to manufacture high-efficiency phosphors and demonstrates that the nano-phosphor materials covered by this method have a wide range of applications.
Advances on ZnO Hetro-Structure as Nanoadsorbant for Heavy Metal Removals
Authors: Rana G.
Published: May 2023

Industrialization is going at an incredibly fast rate, which is putting more and more heavy metals in the water we drink. Almost all heavy metals are very toxic, and even a small amount of these metals in water can be very bad for humans and for the aquatic ecosystems that live in the water. As a result, the removal of heavy metals from industrial effluents is a big deal. Due to their high surface area to volume ratio, nanoadsorbents have received substantial attention in the past decade for their ability to remove heavy metals from water. Due to its good biocompatibility, low toxicity, negative zeta potential, surface changes during development, and redox reactions resulting from the production of efficient photoinduced electron-hole pairs in ZnO nanoparticles, ZnO is a suitable material for heavy metal remediation. In this chapter, we have discussed the synthesis method of ZnO NPs and their nanocomposites. Also in this chapter, we'll go over how ZnO nanostructures can be used to remove heavy metal ions from water. Various ZnO-based nanostorbents, including virgin ZnO NPs, doped ZnO nanostructures, ZnO nanocomposites, and surface-modified ZnO NPs, are fully examined, with statistical analyses of their maximum adsorption capacity for various heavy metal ions (Cd2+, Hg2+, Pb2+, Cr6+, and Cu2+).
A importância das soft skills no trabalho dos profissionais de intervenção precoce na infância
Authors: Franco Vitor
Published: May 2023

A passagem da intervenção precoce no desenvolvimento infantil de uma perspectiva de estimulação para uma abordagem centrada na família implica uma mudança significativa na prática dos profissionais, ao nível técnico e das suas interações e transações com a criança e a família. Competências técnicas e características pessoais interligam-se, e a intervenção representa uma verdadeira relação de ajuda. As soft skills têm vindo a ser investigadas no âmbito de diversas profissões e carreiras e a sua importância tem sido sublinhada. Contudo, este é um estudo pioneiro em que se procura perceber como também os profissionais de Intervenção Precoce na Infância (IPI) valorizam estas dimensões não técnicas. O estudo foi realizado com 247 profissionais de equipas que integram o Sistema Nacional de Intervenção Precoce na Infância, que se pronunciaram sobre a importância das soft skills para a sua prática, através de um questionário com 48 itens. Os resultados obtidos apontam para a valorização de todas as competências identificadas na literatura, sendo especialmente relevantes a empatia, escuta ativa e trabalho em equipa. Foi analisada a valorização das soft skills em função das variáveis idade, género, formação e experiência, tendo os resultados mostrado que só muito pontualmente existem diferenças significativas. Os resultados obtidos são relevantes para uma nova forma de conceber e organizar a formação dos profissionais de IPI, assente no desenvolvimento de competências. Mostram como é importante que o conhecimento teórico sobre o desenvolvimento infantil e os modelos de intervenção se alie à promoção de competências pessoais exigidas pela natureza relacional do seu trabalho.
Investigating Topical Steroid Withdrawal Videos on TikTok: Cross-Sectional Analysis of the Top 100 Videos (Preprint)
Authors: Haddad Firas , Abou Shahla William , Saade Dana
Published: May 2023

BACKGROUND

Social media platforms like TikTok are a very popular source of information, especially for skin diseases. Topical steroid withdrawal (TSW) is a condition that is yet to be fully defined and understood. This did not stop the hashtag #topicalsteroidwithdrawal from amassing more than 600 million views on TikTok. It is of utmost importance to assess the quality and content of TikTok videos on TSW to prevent the spread of misinformation.

OBJECTIVE

This study aims to assess the quality and content of the top 100 videos dedicated to the topic of TSW on TikTok.

METHODS

This observational study assesses the content and quality of the top 100 videos about TSW on TikTok. A total of 3 independent scoring systems: DISCERN, Journal of the American Medical Association, and Global Quality Scale were used to assess the video quality. The content of the videos was coded by 2 reviewers and analyzed for recurrent themes and topics.

RESULTS

This study found that only 10.0% (n=10) of the videos clearly defined what TSW is. Videos were predominantly posted by White, middle-aged, and female creators. Neither cause nor mechanism of the disease were described in the videos. The symptoms suggested itching, peeling, and dryness which resembled the symptoms of atopic dermatitis. The videos fail to mention important information regarding the use of steroids such as the reason it was initially prescribed, the name of the drug, concentration, mechanism of usage, and method of discontinuation. Management techniques varied from hydration methods approved for treatment of atopic dermatitis to treatment options without scientific evidence. Overall, the videos had immense reach with over 200 million views, 45 million likes, 90,000 comments, and 100,000 shares. Video quality was poor with an average DISCERN score of 1.63 (SD 0.56)/5. Video length, total view count, and views/day were all associated with increased quality, indicating that patients were interacting more with higher quality videos. However, videos were created exclusively by personal accounts, highlighting the absence of dermatologists on the platform to discuss this topic.

CONCLUSIONS

The videos posted on TikTok are of low quality and lack pertinent information. The content is varied and not consistent. Health care professionals, including dermatologists and residents in the field, need to be more active on the topic, to spread proper information and prevent an increase in steroid phobia. Health care professionals are encouraged to ride the wave and produce high-quality videos discussing what is known about TSW to avoid the spread of misinformation.

CLINICALTRIAL
mHealth Intervention for Elevated Blood Pressure Among College Students: Single-Arm Intervention Study (Preprint)
Authors: Tran Dieu-My , Dingley Catherine , Bonilla Roger
Published: May 2023

BACKGROUND

Current evidence reveals a growing pattern of hypertension among young adults, significantly increasing their risk for cardiovascular disease later in life. Young adults, particularly those of college age, often develop risk factors related to lifestyle choices in diet, exercise, and alcohol consumption. Developing useful interventions that can assist with screening and possible behavioral modifications that are suitable and appealing to college-aged young adults could help with early identification and intervention for hypertension. Recent studies indicate mobile health (mHealth) apps are acceptable and effective for communication and message delivery among this population.

OBJECTIVE

The purpose of this study was to examine the feasibility of using a mobile smartphone delivery system that provides tailored messages based on participant self-measured blood pressure (BP) with college-aged young adults.

METHODS

Using a single-arm intervention, pilot study design, the mHealth to Optimize BP Improvement (MOBILE) intervention was implemented with college students aged 18 years to 39 years who had systolic BP >120 mm Hg and diastolic BP ≥80 mm Hg. Participants were required to measure their BP daily for 28 days, submit the readings to the app, and receive preset educational text messages tailored to their BP value and related to encouraging healthy lifestyle modifications. Changes in a participant’s BP was evaluated using a mixed regression model, and a postintervention survey evaluated their perspectives on the mHealth intervention.

RESULTS

The participants’ (N=9) mean age was 22.64 (SD 4.54) years; 56% (5/9) were overweight, and 11% (1/9) were obese. The average daily participation rate was 86%. Of the 9 participants, 8 completed the survey, and all indicated the intervention was easy to use, found it increased awareness of their individual BP levels, indicated the text messages were helpful, and reported making lifestyle changes based on the study intervention. They also provided suggestions for future implementation of the intervention and program. Overall, no significant changes were noted in BP over the 28 days.

CONCLUSIONS

The mHealth-supported MOBILE intervention for BP monitoring and tailored text messaging was feasible to implement, as our study indicated high rates of participation and acceptability. These encouraging findings support further development and testing in a larger sample over a longer time frame and hold the potential for early identification and intervention among college-aged adults, filling a gap in current research.
Bayesian networks for disease diagnosis: What are they, who has used them and how? (Preprint)
Authors: Muñoz-Valencia Carlos Segundo , Quesada Jose Antonio , Orozco-Beltran Domingo , Barber Xavier
Published: May 2023

UNSTRUCTURED

A Bayesian network (BN) is a probabilistic graph based on Bayes’ theorem, used to show dependencies or cause-and-effect relationships between variables. They are widely applied in diagnostic processes since they allow the incorporation of medical knowledge to the model while expressing uncertainty in terms of probability. This systematic review presents the state of the art in the applications of BNs in medicine in general and in the diagnosis and prognosis of diseases in particular. Indexed articles from the last 40 years were included. The studies generally used the typical measures of diagnostic and prognostic accuracy: sensitivity, specificity, accuracy, precision, and the area under the ROC curve. Overall, we found that disease diagnosis and prognosis based on BNs can be successfully used to model complex medical problems that require reasoning under conditions of uncertainty.
EFECTIVIDAD DE DIFERENTES TÉCNICAS DE REGISTRO DE ANFIBIOS EN UN HUMEDAL LACUSTRE TEMPLADO DEL CENTRO-ESTE DE ARGENTINA
Authors: Sanchez Laura Cecilia , Prieto Yanina , Maroli Malena , Ronchi Virgolini Ana Laura
Published: May 2023

Las comunidades de anuros y los componentes bióticos asociados, así como el hábitat físico circundante varían entre regiones. El éxito de las investigaciones sobre biodiversidad de anfibios dependerá entonces de conocer la eficiencia de las diferentes técnicas de muestreo que se aplican en cada ambiente particular que es analizado. En este contexto, evaluamos la efectividad relativa de registro (ERR) de cuatro técnicas diferentes en un humedal lacustre localizado en la Reserva Juan Bautista Alberdi (RJBA), en el centro-este de Argentina. Se efectuaron los relevamientos de diciembre de 2021 a marzo de 2022 (temporada de verano), sumándose un muestreo de otoño (mayo/2022). Se emplearon a) trampas de caída, b) muestreos de larvas con red, c) transectas de prospección auditiva y d) transectas de prospección visual. En cada caso, se calculó la ERR estandarizando los registros de acuerdo al esfuerzo de muestreo medido en minutos. Para estudiar el efecto de la técnica de muestreo sobre la ERR se realizó un modelo lineal randomizado mediante un test de permutación, aplicando 1,000 iteraciones. Se registraron un total de 11 especies, siendo Boana pulchella, Scinax nasicus y Rhinella dorbignyi las detectadas con mayor frecuencia. La técnica de muestreo influyó en la ERR (P = 0.001). El transecto de prospección auditiva resultó la técnica más exitosa, con una ERR del 24.44%, seguida por la búsqueda de larvas con red (3.70%) y el transecto de prospección visual (3.38%). No obstante, estas dos últimas permitieron encontrar especies no detectadas con la primera. Consecuentemente, un diseño integrando diferentes técnicas es necesario para estudiar adecuadamente las comunidades de anfibios de la RJBA. Mejorar la efectividad de los muestreos permite fortalecer nuestra comprensión sobre la biodiversidad de este grupo taxonómico, tan necesario en el contexto de declinación global actual.
Extensive Magnitudes: Metaphysics, Representation and Epistemology
Authors: Marshall Oliver R.
Published: May 2023

Extensive Magnitudes: Metaphysics, Representation and Epistemology
Against Magnitude Realism
Authors: Lee Geoffrey
Published: May 2023

In recent work, Christopher Peacocke has argued for a kind of realism (or anti-reductionism) about magnitudes such as temperature and spatial distance. Peacocke’s argument is that magnitudes are an ineliminable commitment of scientific and everyday explanations (including high-level explanations), and that they are the natural candidates for semantic values of our ordinary magnitude talk, and for contents of our mental states. I critique these arguments, in particular focusing on whether the realist has a satisfactory account of how high-level magnitude facts are grounded in lower-level facts. I argue that a less realist (i.e., more reductionist approach) is preferable, or at least viable. I also aim to substantially clarify what is at stake in the debate.
Acceso a la justicia: posible Zahir en la jurisprudencia mexicana
Authors: Camacho Ortiz D. A.
Published: May 2023

Pese a no aparecer en ninguna disposición constitucional o legal relevante, el empleo de “acceso a la justicia” se ha ampliado notablemente en la jurisprudencia. Analizamos el Proyecto de Florencia como antecedente de este fenómeno y rastreamos sus propuestas en 191 tesis jurisprudenciales publicadas entre 1994 y 2019. Empleando algunas categorías analíticas, concluimos que la influencia de dicho proyecto es notoria en el reconocimiento de deberes judiciales contra el formalismo judicial y menor en la flexibilización del amparo o el reconocimiento de derechos sociales. Identificamos distintos sentidos de la expresión, criticando aquel que entiende acceso a la justicia como un derecho a “la resolución justa e igualitaria de los conflictos”, para lo cual empleamos la imagen del Zahir borgiano.
Análisis de la normatividad nacional e internacional sobre el derecho de atención en salud integral de las personas migrantes venezolanas en situación de irregularidad en Colombia
Authors: León Vargas Georgina Isabel de , Oñate Carrillo Mariana Isabel , Cárdenas Aroca Jhorman Elí
Published: May 2023

En este artículo se presenta una revisión de la normatividad nacional e internacional que fundamenta las garantías del derecho a la salud integral hacia las personas migrantes que se encuentran en situación de irregularidad en el territorio colombiano. Se logró determinar que bajo el marco del desarrollo progresivo de los derechos económicos, sociales y culturales, hoy la salud integral de las personas migrantes en situación de irregularidad debería estar más y mejor garantizada, pero no ocurre así. Se observa que Colombia no ha avanzado de forma constante y eficiente en la concreción de este derecho en su legislación interna, esto a pesar de que lleva varios años enfocando esfuerzos en estos temas.
Determinantes de las designaciones de ministros de la Suprema Corte de Justicia de México, 1995-2021
Authors: Díaz Domínguez Alejandro , Saavedra Herrera Camilo
Published: May 2023

La reforma judicial de 1994 consolidó a la Suprema Corte de México como órgano de justicia constitucional. Desde su entrada en vigor y hasta 2021, las veintisiete vacantes que se abrieron en el tribunal han sido cubiertas con un procedimiento en el que las nominaciones corresponden a la Presidencia de la República, y las designaciones, al Senado. ¿Qué factores han influido en los resultados de estos procesos de designación? Este trabajo ofrece una respuesta a partir de una sistematización original del universo de designaciones efectuadas en el periodo 1995-2021. En línea con la literatura comparada sobre nombramientos judiciales, el trabajo concluye que han sido determinantes tanto los elementos de entorno político, como las características de las personas nominadas.
Liberdade de expressão e o discurso profano: reflexões sobre a um caso concreto no Brasil
Authors: Maia Veríssimo Vitor , Campos Galuppo Marcelo
Published: May 2023

Apesar de a liberdade de expressão ser prevista como direito fundamental pela Constituição Brasileira, há aparente conflito entre esse direito e outros também constitucionalmente protegidos, como a liberdade religiosa. Defendemos o direito do artista divulgar sua obra, mesmo que envolva a crítica das instituições sociais. Investigamos criticamente a decisão em primeira instância do caso da Arquidiocese de Goiânia contra a artista Ana Smile para analisar a atuação do Estado em casos que envolvem liberdade de expressão. Busca-se compreender de que maneira deveria o Estado dirimir a ofensividade do discurso e o direito de se expressar, concluindo ser necessária uma legislação infraconstitucional mais permissiva quanto à liberdade de expressão, em especial dos artistas plásticos.
La justicia indígena como resignificadora de los derechos humanos en el sistema de justicia penal de México
Authors: Vivar Vera Juliana
Published: May 2023

Se realiza un análisis constructivo del sistema de justicia penal mexicano en los pueblos indígenas para una justicia penal pluricultural. El objetivo es proponer una justicia penal con identidad mexicana que resignifique los derechos humanos de las personas indígenas en el sistema penal desde una postura de mesura decolonial y comprensión del concepto de dignidad humana con protagonismo originario de la cultura y costumbre para entender el delito, el daño y la solución. Para lograrlo, se analiza la incompatibilidad del sistema penal con la cosmovisión indígena y se le muestra como herramienta discriminatoria y de violencia que victimiza a las personas indígenas. Se concluye destacando elementos materiales originarios como medida inclusiva y de fortalecimiento a la justicia penal mexicana.
Derecho y democracia en la periferia de la sociedad moderna. Estructuras, semánticas y expectativas
Authors: Zamorano Farías Raúl
Published: May 2023

Sobre la base de la arquitectura conceptual de la teoría general de los sistemas sociales (TGSS) se analiza el problema del orden jurídico-político en la periferia de la sociedad moderna, rastreando las formas de institucionalización de las estructuras, semánticas y expectativas y los artefactos que se reproducen y parasitan en esas estructuras con las cuales, paradójicamente, se construye el orden funcional y diferenciado preeminente en la modernidad de la sociedad moderna.Si la captura del aparato estatal ha sido una de las características que definen la articulación del orden en la región, cómo se estabilizaron esas estructuras, cómo incluso definen las expectativas que orientan los presupuestos de la diferenciación funcional, operando factualmente con lógicas de un orden social estratificado y potenciando las prácticas clientelares.
The Immunohistochemical Staining of Vimentin and E-Cadherin in Bladder Cancer Patients Infected with Hepatitis C Virus
Authors: Ismael May K. , Qaddoori Yasir B. , Shaban Mustafa N. , AL-Rubaii Bahaa Abdullah Laftaah
Published: May 2023

The invasion and spread of cancer cells are two of the most notable characteristics of malignant tumors. Recent studies suggest that the epithelial-mesenchymal transition (EMT) has been linked to this significant occurrence. It is linked to the absence of the epithelial brow and the presence of mesenchymal facial hair. The aims of the present study were to explore the immunohistochemical staining of vimentin and E-cadherin ex vivo as EMT markers and assess their potential as predictive biomarkers for transitional cell cancer (TCC). In this study, 55 paraffin-embedded biopsies from TCC patients and 10 autopsies that appeared to be normal were included. Immunohistochemistry was used to produce patterns of vimentin and E-cadherin expression. When compared to female patients, the expression of E-cadherin and vimentin significantly increased with increasing age in male patients (> 50 years). In contrast to the considerable rise in vimentin expression in higher grades and stages of the tumor, E-cadherin expression was significantly reduced with tumor stage and grade. The findings of this study reveal that elevated vimentin and reduced E-cadherin are important indicators associated with a poor prognosis for TCC.
Correlation of Interleukin-17 and 23 Inflammatory Markers with Genetically Transmitted Spondyloarthritis Patients at a Tertiary Care Facility, South India
Authors: Jayaprakash T. , Leela K.V. , Venkatesan Balamurali , Ravi Sujith , Muthamilan Om Lokesh
Published: May 2023

Human leukocyte antigens (HLA) are genetically derived proteins in the major histocompatibility complex. They help distinguish “self” and “non-self” antigens and are essential in interacting with the immune cells inside the body. The present research work examines the prevalence of HLA-B27 among patients suspected of Spondyloarthritis (SpA), which has also been correlated with Interleukin-17/23 Inflammatory Markers and other clinical manifestations and was carried out between August 2017 to January 2021. The patient’s blood samples were collected and tested for HLA-B27 and Interleukin-17/23 inflammatory markers. Among 289 SpA patients, 60% (172) were males, and 40% (117) were females, with a ratio of 1.5:1. Ankylosing Spondylitis (65.1%) was found to be the most prevalent subgroup of SpA among the patients, closely followed by reactive arthritis (21%), psoriatic arthritis (10.7%), undifferentiated spondyloarthritis (2.1%), and inflammatory bowel disease with associated arthritis (1%). HLA-B27 was found to be positive in 54% (156) out of 289 patients. Normal IL-17 ranges were seen in 42% of HLA-B27- positive patients, while increased IL-17 was seen in 58% of the population with positive HLA-B27 cases. IL-23 was found within normal ranges in 40% of positive HLA-B27 cases, while it was found to be increased in 60% of the positive HLA-B27 positive subjects. We concluded that HLA-B27 was found to be positive among more than half of the patient population with SpA. The early detection of HLA-B27 may aid in changing lifestyle to prevent Spondyloarthritides.
Prevalence, Risk Factors and Antibiotic Susceptibility of Urinary Tract Infections among Pregnant Women: A Study in Damt District Yemen
Authors: Al-Badaii Fawaz , Al-Tairi Mohammed , Rashid Amina , Al-Morisi Sumaya , Al-Hamari Najla
Published: May 2023

Urinary tract infections are the most common illnesses that impact pregnant women. This study aimed to investigate bacterial urinary tract infections and antibiotic susceptibility profiles in pregnant women. This study was conducted on pregnant women between April and October 2021 in clinics and hospitals in the Damt district. Midstream urine samples were collected, cultured, identified and tested for antibiotic susceptibility. The prevalence of UTI in pregnant women was 210/350 (60%). Escherichia coli accounted for 90/210 (42.9%), Staphylococcus aureus 50/210 (23.8%), and Klebsiella pneumoniae 25/210 (11.9%). Staphylococcus epidermidis, Pseudomonas aeruginosa, and Proteus mirabilis exhibited 15/210 (7.1%) of each with the moderately identified bacterial species. Antimicrobial sensitivity testing showed that bacterial isolates were resistant to amoxicillin (80-100%), ceftriaxone (40-70%), gentamycin (0-60%), amikacin (0-50%), tetracycline, ciprofloxacin, azithromycin, and amoxiclav (0-40%), and azithromycin (0-30%). Significant bacteriuria was associated with age (p = 0.01), pregnancy trimesters (p = 0.00), gestation (p = 0.00), and residence (p = 0.03), whereas there was no association with education (p = 0.05). Most isolates have become resistant toward antibiotic used in the study treatments, especially ceftriaxone and amoxicillin. Therefore, it is recommended that pregnant women undergo health education on the prevalence and causes of urinary tract infections.
Study and Analysis of Non-Newtonian Fluid Speed Bump
Authors: Bamborde Atul , Kharkar Akshta , Hatwade Mukul , Raut Deepak , Gupta Mrs. Laxmi
Published: May 2023

Abstract: Research and investigation of non-Newtonian speed bumps with conventional speed bumps, are constructed from substances that behave like non-Newtonian fluids, such as shear thickening fluids or gels. In comparison to conventional speed bumps, the use of such materials in speed bumps may have a number of benefits, including a smoother ride, less noise, and better fuel efficiency. Non-Newtonian fluids have characteristics that set them apart from conventional fluids, like viscosity that varies depending on how much force is applied. Use various textures, color, and forms to depict the fluid's fluctuating viscosity and elasticity to express these special qualities in your college. The idea of non-Newtonian speed bumps next be discussed, along with the many non-Newtonian materials that can be used.