bluuebunny/crossref_metadata_2025 huggingface dataset:
The Utility of Point-of-Care Ultrasound in Critically Ill Patients Undergoing Renal Replacement Therapy
Authors: Passos Rogerio , Flato Uri Adrian Prync , Sanches Paula Rodrigues , Pellegrino Carolina , Cordioli Ricardo , Silva Bruno Caldin , Galdino Felipe , Barros Dalton Souza , Coelho Fernanda Oliveira , Bravim Bruno , Correa Thiago
Published: January 2024

Keywords: renal replacement therapy. Point-of-Care Ultrasound; intensive care; acute kidney injury; nephrologist.Point of care ultrasonography (POCUS) is gaining heightened significance in critical care settings as it allows for quick decision making at the bedside. While computerized to-mography is still considered the standard imaging modality for many diseases, the risks and delays associated with transferring a critically ill patient out of the Intensive Care Unit (ICU) have prompted physicians to explore alternative tools. Ultrasound guidance has increased safety of invasive procedures in the ICU, such as the placement of vascular catheters and drainage of collections. Ultrasonography is now seen as an extension of the clinical examination, providing quick answers for rapidly deteriorating patients in the ICU. The field of nephrology is increasingly acknowledging the value of diagnostic Point-of-Care Ultrasound (POCUS). By employing multi-organ POCUS, nephrologists can address specific queries arising during the diagnosis and treatment of patients with acute kidney injury. This approach aids in ruling out hydronephrosis and offering immediate information on hemodynamics, thereby consolidating patient data and facilitating the development of personalized treatment strategies.
Liver-Kidney-Heart Axis – A Clinical Challenge
Authors: Neto Dina Fernandes , Blanco Iago , Viu María Melendo , Perez David Dobarro , Romo Andrés Iñiguez
Published: January 2024

Cirrhosis is a chronic disease with multiple etiologies, multiple manifestations, and multi-organ involvement. Affects about 200 million people worldwide. Its main complication is Portal hypertension (PHT). Cirrhotic cardiomyopathy is a consequence of PHT, with heart failure (HF) being the main manifestation. On the other hand, for people with cardiopathy due to other reasons beyond cirrhosis, the presence of the last could act as a trigger to acute HF. Finally, when HF and cirrhosis coexist, the renal system suffers the most, originating from type-5 cardio-renal syndrome, a complex entity with many challenges in diagnosis and treatment. This entity was recently defined and there is a lack of data on the epidemiology of this syndrome.
A 77-year-old woman, with cardiovascular risk factors; heart failure with reduced ejection fraction (HFrEF), secondary ischemic and valvular cardiopathy, chronic Kidney disease (CKD), and stable decompensated cirrhosis, went to the emergency department after progressive abdominal perimeter augmentation, legs’ edema and hematochezia. It was assumed acute decompensated cirrhosis and acute decompensated chronic kidney disease, had triggered digestive bleeding and the patient stayed hospitalized. Intravenous diuretic therapy was started but, the ascites and kidney function got worse, the Nt pro-BNP grew until 1125000 pg/ml, and a transthoracic echocardiography showed important signs of congestion, isolated right ventricular dysfunction, with normal cardiac output. After teamwork’s discussion, a type-5 cardio-renal syndrome was assumed deciding not to act on tricuspid regurgitation due to the maladaptive RV remodeling. Hepatorenal syndrome treatment was begun (oral terlipressin and intravenous albumin), followed by decongestion therapy, resulting in a marked improvement in clinical presentation. The kidney, heart, and liver recovered to these basal states.
With this clinical case, the authors want to show how multidisciplinary management is important to face tricuspid regurgitation and right ventricular dysfunction.
Current Management and Treatment Paradigms of Gastroesophageal Reflux Disease Following Sleeve Gastrectomy
Authors: Masood Muaaz , Low Donald E , Deal Shanley B. , Kozarek Richard A.
Published: January 2024

Obesity is associated with serious comorbidities and economic implications. Bariatric surgery, most commonly Roux-en-Y gastric bypass and sleeve gastrectomy, are effective options for weight loss and improvement of obesity-related comorbidities. With the growing obesity epidemic, there has been a concomitant rise in bariatric surgeries, particularly in sleeve gastrectomy, which has been the most widely performed bariatric surgery since 2013. Gastroesophageal reflux disease (GERD) is highly prevalent in obese individuals, can significantly impact quality of life and may lead to serious complications. Obesity and GERD both improve with weight loss. However, as the incidence of sleeve gastrectomy rises, recent data has revealed a risk of exacerbation of pre-existing GERD or the development of de novo GERD following sleeve gastrectomy. We performed a detailed review of GERD post-sleeve gastrectomy, including its overall incidence, pathophysiology and current treatment paradigms.
Utilizing an Internet of Things (IoT) Device, Intelligent Control Design and Simulation for an Agricultural System
Authors: Amertet Finecomess Sairoel , Gebresenbet Girma , Alwan Hassan Mohammed
Published: January 2024

In an agricultural system, finding suitable watering, pesticide, and soil content to provide the right nutrients for the right plant is a mystery so far. Plants cannot speak and cannot ask which food they require. These problems can be addressed by applying intelligent (fuzzy logic) controllers to IoT devices in order to enhance communication between crops, ground mobile robots, aerial robots, and the entire farm system. The application of fuzzy logic in agriculture is a promising technology that can be used to optimize crop yields and reduce water usage. It was developed based on language and the air properties in the agricultural fields were formulated. The entire system was simulated in the MATLAB/SIMULINK environment with Cisco Packet Tracer integration. The inputs for the system were soil moisture sensors, temperature sensors, humidity sensors, and outputs were pump flow, valve opening, water level, and moisture in sounding. The obtained results were the output of opening valve, moisture in sound, pump flow rate, outflows, water level, and ADH values, which are 10.00000013 rad/sec, 34.72%, 4.494%, 0.025 m^3/sec, 73.31 cm^3, and 750 values respectively. The outflow rate increase indicates that the water is released from the tanks, and the control signal fluctuates, indicating that the valve is opening.
Estimation of Axial Young’s Modulus of Fibrous Composites Using Finite Element Analysis
Authors: Itu Calin , Scutaru Maria Luminita , Vlase Sorin
Published: January 2024

Knowing the mechanical properties of fibrous composite materials used in aeronautical industry from the design phase is a primary objective for designers. There are many methods for determining them, but they are laborious and require a long calculation time. And some of the methods are very approximate, giving only upper and lower bounds for these values. Experimental measurements also consume time and others resources. A method for sufficiently accurate and quickly obtained estimation of the engineering constants of the homogenized material is presented in the work. FEM is used to determine the natural frequencies of a standard bar, for which there are sufficiently precise classical methods for expressing these constants according to the properties of the homogenized material. In this way, these sought constants can be determined. In the work, Young's modulus will be determined for such a material, using the relationships that provide the proper pulsations for the longitudinal vibrations. Within the adopted model, transverse and torsional vibrations will be eliminated by blocking the nodes on the surface of the bars. In this way, more longitudinal self-pulsations can be obtained, so the precision in calculating the Young's modulus will increase.
Study on Suburban Land Use Optimization from the Perspective of Flood Mitigation——a Case Study of Pujiang Country Park in Shanghai
Authors: Xu Hui , Wang Chunyang , Yu Xinchun , Gao Junlong , Wen Jiahong , Qin Qianqian
Published: January 2024

The integration of nature-based solutions into land use optimization has emerged as a focal point of current research, primarily due to its efficacy in mitigating flooding impacts and fostering sus-tainable development in both urban and rural areas. Utilizing Shanghai Pujiang Country Park as a case study, this paper conducts a simulation analysis to assess the flood mitigation effectiveness of three distinct land use patterns (Natural scenario, Scenario N; Complete urbanization scenario, Scenario U; Country Park Planning scenario, Scenario P) under five stormwater scenarios with re-turn periods of 2, 5, 10, 20, and 50 years. The findings reveal that Scenario P exhibits superior flood mitigation performance, particularly under stormwater scenarios with a return period of less than 50 years. Building upon these results, the paper proposes recommendations for optimizing land use with a focus on mitigating the impact of flooding. This study is crucial for comprehending the mechanisms involved in urban stormwater logging mitigation through land use methods and holds significance for decision-making in land use and planning at the micro level.
Greener Approaches to Combat Biofilm’s Antimicrobial Resistance On 3D Printed Materials: A Systematic Review
Authors: Sebbar Khaoula , El Aabedy Amal , Ibnsouda Koraichi Saad , Ulag Songul , Gunduz Oguzhan , El Abed Soumya
Published: January 2024

In recent years, Additive Manufacturing (AM), commonly referred to as 3D printing, has garnered the attention of the scientific community due to its capacity to transform ordinary and traditional items into customized materials at an affordable cost, through various AM processes. Antimicrobial/antibiofilm 3D printed materials are one of the most trending research topics, owing to the growing concerns over the emergence of complex microbial structures called "biofilms" on various surfaces. The review provides an overview of the evolution of additive manufacturing (AM) technologies and their various derivatives, along with a brief description of their materials and applications. It also introduces how biofilms can represent an advantageous lifestyle for microbial populations. The primary objective of this research was to conduct a systematic review on the development of planctonic or biofilm forms of microorganisms on 3D printed materials. The article summarizes commonly studied microorganisms on these materials and presents their 3D printing process, materials, as well as the fields covered by each of the analyzed papers. To the best of our knowledge, this is the first all-inclusive systematic review that amalgamated research conducted in diverse fields to assess the development of biofilms on surfaces produced through three-dimensional printing. Most notably, this review presents a comprehensive account of sustainable approaches for producing antimicrobial materials through 3D printing. Additionally, we assess their advancements in various fields such as medicine, environment, agri-food, and other relevant sectors. The findings of our literature review can be used to recommend appropriate microorganisms, 3D printing materials, and technologies for academic and industrial research purposes focusing on the development of microbial biofilms on 3D printed surfaces. Furthermore, it highlights the potential of environmentally-friendly modified AM technologies to combat biofilms in clinical and non-clinical areas. Our goal with this review is to help readers gain a better understanding of fundamental concepts, inspire new researchers, and provide valuable insights for future empirical studies focused on eradicating biofilms from 3D printed materials.
Effect of Rapeseed Imidazoline Addition on the Properties of Lab Aged 35/50 Pen Grade Bitumen
Authors: Jurczak Robert
Published: January 2024

For successful reuse of old asphalt as reclaimed asphalt pavement (RAP) added to new bituminous mixtures it is necessary to improve some of its properties. This can be attained, for example, by adding an appropriate rejuvenating agent. The aim of this study was to evaluate the properties of a lab aged 35/50 pen grade bitumen, rejuvenated by addition of two varieties of rapeseed imidazo-line. Both short-term and long-term ageing were simulated using the Rolling Thin Film Oven Test (RTFOT) and Pressure Ageing Vessel (PAV), i.e. standard lab ageing methods. The first step in-cluded determination of the basic properties of the analysed pen grade bitumen. Fatigue cracking resistance of the bitumen was checked as the next step. The dynamic shear rheometer (DSR) test was carried out for this purpose, at the intermediate operating temperature of road pavements. The obtained data were then used to calculate the fatigue cracking critical temperature (FCCT). A ductility test was also carried out in a ductilometer, in which the applied tensile force was meas-ured. The obtained results demonstrated a beneficial effect of rapeseed imidazoline on the prop-erties of the tested pen grade bitumen after ageing, when added at a rate of 6% and more.
High Doses of Radiation Cause Cochlear Immunological Stress and Sensorineural Hearing Loss
Authors: Shi Mengwen , Yang Huiwen , Wang Ye , Lai Chengcai , Yu Jintao , Sun Yu
Published: January 2024

Radiotherapy is a crucial treatment for head and neck malignancies, but it usually leads to sensorineural hearing loss (SNHL). Changes in the immune microenvironment and sensorial neuroepithelium of the inner ear after radiation exposure remain poorly understood. This study investigated cochlear morphology and macrophages in the inner ear after high-dose irradiation. The heads of 8-week-old Cx3cr1GFP/+ heterozygous male mice were irradiated with 30Gy X-rays and biological samples were taken on the 1st, 7th, and 10th days after irradiation. Auditory brainstem responses were used to assess auditory function in mice. The changes of basal membrane hair cells, spiral ganglion (SGN), and inner ear macrophages were observed using hematoxylin-eosin (HE) staining and immunofluorescence staining. The expression of inflammatory mediators in the inner ear was detected by reverse transcription-polymerase chain reaction (RT-PCR) in cochlear tissue. As a result, there was no significant hair cell loss after high doses of radiation, but the mice developed full-frequency hearing loss on day 10 when HE staining revealed SGN atrophy and immunofluorescence revealed decreased neurofilament expression. The number of macrophages in the inner ear decreased over time. RT-PCR showed that cochlear inflammatory factors and chemokines were briefly up-regulated on the first day after irradiation and then decreased over time. In summary, high-dose irradiation causes acute SNHL that does not involve hair cell loss and may be associated with SGN changes. Radiation-induced SNHL is accompanied by a reduction in cochlear macrophages and changes in the immune microenvironment, but the relationship between the two has yet to be explored.
New Generation of Gene Therapies as the Future of Wet AMD Treatment
Authors: Blasiak Janusz , Pawlowska Elzbieta , Ciupinska Justyna , Derwich Marcin , Szczepanska Joanna , Kaarniranta Kai
Published: January 2024

Age-related macular degeneration (AMD) is an eye disease and the most common cause of vision loss in the Western World. In its advanced stage, AMD occurs in two clinically distinguished forms: dry and wet, but only wet AMD is treatable. However, the treatment based on repeated injections with vascular endothelial growth factor A (VEGFA) antagonists may at best stop the disease progression and prevent or delay vision loss but without an improvement of visual dysfunction. Moreover, it is a serious mental and financial burden for patients and may be linked with some complications. The recent first success of intravitreal gene therapy with ADVM-022, which transformed retinal cells to continuous production of aflibercept, a VEGF antagonist, after a single injection, has opened a revolutionary perspective in wet AMD treatment. Promising results obtained so far in other ongoing clinical trials support this perspective. In this narrative/hypothesis review, we present basic information on wet AMD pathogenesis and treatment, the idea of gene therapy in retinal diseases, update evidence on completed and ongoing clinical trials with gene therapy for wet AMD, and perspectives on the road to the clinic of “one and done” therapy for wet AMD to replace a lifetime of injections. Gene editing targeting the VEGFA gene is also presented as another gene therapy strategy to improve wet AMD management.
Use of Immune Modulation and Chemotherapy Management in the Treatment of Gliomas
Authors: Foster Devon , Kioutchoukova Ivelina , Davidson Caroline , Thakkar Rajvi N , Foreman Marco , Molina Valero Eduardo , Barnes Demani , Lucke-Wold Brandon
Published: January 2024

Gliomas are central nervous system (CNS) derived tumors that originate from glial cells and affect six per 100,000 people in the United States. They are the most common form of CNS neoplasm and are highly diffusely infiltrative to surrounding brain tissue. Gliomas of diffusive nature are classified into different subcategories: astrocytomas, oligodendrogliomas, and ependymomas. Computed tomography (CT) and Magnetic Resonance Imaging (MRI) are used to determine tumor category and spread which may dictate treatment options. This paper focuses on emerging treatments of chemotherapy management with temozolomide and Avastin as well as emerging immune modulation treatment with vaccinations, manipulation of cellular checkpoints CTLA-4 and PD-1, co-receptor modulation of neuropilin-1, CAR-T cell therapy, and CRISPR-Cas9 gene editing.

The employment of TMZ and BEV has been supported in the literature, however, more research is necessitated to fully optimize regimens and to avoid immune- and toxicity-related effects of these drugs. Moreover, an even closer consideration is warranted for current immunotherapies as they are in their infancy compared to TMZ and BEV. Thus, although promising emerging treatment options, therapies involving cancer vaccines, ICIs, immune modulation of neuropilin-1, CAR-T, and CRISPR-Cas9 technology require further investigation into their long-term efficacy and utility in treating gliomas.
Environmental Stressors of Mozambique Soils Quality
Authors: Pereira Mário J.S.L. , Esteves da Silva Joaquim C.G.
Published: January 2024

Mozambique is one of the poorest countries of the world. However, it has natural resources and if they are managed under sustainable development principles, Mozambique can overcome the current problems. In the present socio-economic status, soil is one of its most important resources and must be protected from pollution and from degradation. This review focuses on the identification and discussion of the main soil quality stressors, namely: soil fertility; deforestation and its sources: agriculture, timber harvesting, charcoal production and uncontrolled fires; mining activities, manly gold artisanal explorations and industrial open-pit coal mining. The sustainable use of the natural resources is mandatory to allow future generations to continue profiting for this nature-based wealth.
Electrical Conductivity, EMI Absorption Shielding Performance, Curing Process and Mechanical Properties of Rubber Composites
Authors: Kruželák Ján , Kvasničáková Andrea , Džuganová Michaela , Dosoudil Rastislav , Hudec Ivan , Krump Henrich
Published: January 2024

Three types of the composites were tested for electromagnetic interference (EMI) absorption shielding effectiveness, curing process and physical-mechanical properties. In the first type of composites, manganese-zinc ferrite, nickel-zinc ferrite, and both fillers in their mutual combinations were incorporated into acrylonitrile-butadiene rubber. The overall content of the filler, or fillers combinations was kept on 200 phr. Then, carbon black, or carbon fibres, respectively were incorporated into each rubber formulation in constant loading - 25 phr, while the content of magnetic fillers was unchanged - 200 phr. The work was focused on the understanding of correlation among electromagnetic shielding parameters and electrical conductivity of composites in relation to their EMI absorption shielding effectiveness. The absorption shielding ability of materials was evaluated within the frequency range from 1 MHz to 6 GHz. The study revealed good correlation among permittivity, conductivity, and EMI absorption effectiveness. Although, the absorption shielding efficiency of composites filled only with ferrites seems to be the highest, the absorption maxima of those composites were reached over 6 GHz. The application of carbon based fillers resulted in higher electrical conductivity and higher permittivity of composites, which was reflected in their lower absorption shielding performance. Though, the composites with filled with ferrites and carbon based fillers absorbed electromagnetic radiation within the desired frequency range. The presence of carbon based fillers caused the improvement in tensile behavior of composites. The study also demonstrated that the higher was the ratio of nickel-zinc ferrite in magnetic fillers combinations, the higher was the absorption shielding performance.
A Bibliographic Analysis of Biofilm Control
Authors: Ding Yuanzhao
Published: January 2024

This paper explores the intricate world of microbial life, focusing on biofilm as a dynamic consortium of bacteria forming complex networks within a self-produced matrix of extracellular polymeric substances (EPS). Analogous to a bacterial house, these structures provide both shelter and support, playing a pivotal role in the microbial realm with dual effects on human and environmental contexts. Biofilm's significance extends beyond its microcosmic architecture, positively contributing to heavy metal removal, electricity generation through microbial fuel cells, and structural remediation, while also posing threats with detrimental formations implicated in conditions from lung to urinary tract infections. Control of biofilm becomes imperative to unlock its positive attributes and mitigate potential negatives, serving as a cornerstone for environmental remediation, sustainable energy, and infrastructure maintenance. Employing a comprehensive bibliographic approach, this study identifies keywords, countries, and organizations influencing biofilm research, proposing innovative avenues like machine learning for future exploration. The aim is not only to contribute to existing knowledge but to pioneer cutting-edge strategies for biofilm optimization and challenge mitigation, shaping its trajectory towards sustainable applications across diverse fields.
Patients' Perceptions Resulting from the Contact with Emergency Departments using the Manchester Triage System Protocol
Authors: Sousa Marina , Cunha Maria Nascimento , Rodrigues José Salgado
Published: January 2024

Emergency is a health condition that poses an imminent risk to life. In this context, operations and triage protocols play an important role in the correct functioning of the Emergency Department, a key component of national health systems. The aim of the study was to explore and describe the experiences of a group of patients regarding emergency departments that use the Manchester Triage System, a triage protocol widely adopted in Europe. The research approach used was phenomenography, which allows us to explore in depth the diversity of experiences lived by a group of patients. The data was collected through semi-structured interviews and analysed to identify the categories that allows a qualitative description of patient’s experiences. The results are structured in the following categories: “Healthcare professional roles“, “Waiting time to be cared“, “Triage protocol“ and “Emergency department utilization“. These results can be used to improve the way patients experience emergency situations and to contribute to increasing knowledge about the impact of emergency departments and triage protocols on patients.
Genome–Wide Identification, Characterization and Expression Profile of F–box Protein Family Genes Shed Light on Lateral Branch Development in cultivated peanut (Arachis hypogaea L.)
Authors: Li Chuheng , Guo Liguo , Wang Weiqian , Miao Penghui , Mu Guojun , Chen Charles Y. , Meng Chengsheng , Yang Xinlei
Published: January 2024

: F-box proteins are a large gene family in plants, and play crucial roles in plant growth, development, and stress response. However, a comprehensive investigation of F-box family genes in cultivated peanut (Arachis hypogaea L.), has not been undertaken. In this study, we used a bioinformatics approach to identify and analyze F-box protein family genes in the cultivated peanut genome, and examined their expression profiles. Herein, a total of 95 F-box protein family members on 18 chromosomes were identified in cultivated peanut, which were sequentially designed as AhFBX1-AhFBX95. Phylogenetic analysis classified these AhFBXs into four different groups (Group I - IV), and eight subfamilies based on the structural domains of the C-terminal. Structural analysis revealed the presence of ten unique motifs within these genes. Additionally, the investigation of non-synonymous and synonymous substitution rates (Ka/Ks), and synteny in the F-box proteins, provided valuable insights into the evolutionary and domestication processes of AhFBX genes in peanut. Furthermore, in silico expression profiling of 22 different tissues demonstrated that most genes were predominantly expressed in leaves, pistils, and the aerial gynophore tip, while some members showed tissue-specific expression at the apex of both vegetative and reproductive shoots. Subsequently, we validated the expression of 9 differentially expressed genes (DEGs) using transcriptomeic data of lateral branch development and qRT-PCR analysis. These DEGs may be involved in regulating the development of lateral branches and subsequently affect the architecture of peanut plants.
Proteomics As A Valid Tool In Biomarker Discovery For Alzheimer's Disease
Authors: Magnelli Valeria
Published: January 2024

Alzheimer’s disease (AD) is one of the most widespread neurodegenerative diseases affecting people averaging over 65 years. It manifests with severe cognitive damage, loss of memory, impairment in performing activities, ventricular expansion and final dementia. AD is associated with the deposit of amyloid β protein (Aβ) plaques, intracellular neurofibrillary tangles (NFTs), progressive inflammation and impairment of synaptic transmission and of mitochondrial function. Due to the poor diagnostic tools for the early stages of the disease, proteomics biomarkers have gained a paramount role because they can monitor the prodromal variations of the disease-linked molecular changes. Further, proteome biomarkers can help the follow up of AD progression over time and aid in setting personalized medical care, before the catastrophic consequences of dementia occurs. Research has focused on the identification of proteome biomarkers in cerebrospinal fluid (CSF) and plasma, which are discussed in the present review, but also in other matrices, as saliva and urine, revealing the high potentiality of proteomics approach and, at the same time, the difficulty to identify, for the different stages of the disease, sensitive and specific biomarkers clinically available.
High-Gravity Brewing of Bohemian Lager with Wheat Adjuncts
Authors: Kinčl Tomáš , Dostálek Pavel , Olšovská Jana , Jung Rudolf
Published: January 2024

High gravity brewing (HGB) and adjunct use are common practices in industrial breweries. This work studied the impact of HGB and wheat adjuncts on beer characteristics. Parameters were evaluated in full-malt beer and beers prepared with 30 % wheat grits (WG) and wheat flakes (WF) in the grist and the effect of HGB was examined. Five beers were prepared; one control, two with different original gravity (OG) with WF and two with WG. Beers with higher OG were diluted to a lower OG and control beer was prepared too. The application of wheat adjuncts increased foam stability but HGB did not affect the beer foam. HGB beers had a remarkably higher ester concentration than other samples, and beers with WG also had a significantly higher ester content. Decreased higher alcohols to esters ratio in HGB beers affected the balanced flavour profile of the lager beer. There was a significantly lower content of unwanted volatiles such as vicinal diketones and dimethyl sulphide in HGB beers. The application of HGB mostly did not affect the beer ageing characteristics such as carbonyl compounds and thiobarbituric acid number.
Prognostic Factors Associated with Tumor Recurrence and Overall Survival in Soft Tissue Sarcomas of the Extremities in a Colombian Reference Cancer Center
Authors: Díaz-Casas Sandra , Villacres Juanita Martinez , Lehmann Carlos , Garcia Mauricio , Mariño Ivan , Angel Javier , Suarez Raul , Duarte Carlos , Sanchez Ricardo
Published: January 2024

Introduction:
Soft tissue sarcomas (STS) are low-incidence tumors whose clinical and histopathological factors are associated with adverse oncological outcomes. This study evaluated prognostic factors (PF) associated with tumor recurrence and overall survival (OS) in patients diagnosed with STS of the extremities, treated at the Instituto Nacional de Cancerología (INC), Bogotá, Colombia.

Materials and methods:
An analytical observational study of a historical cohort was carried out, including patients diagnosed with STS and managed surgically in the Functional Unit for Breast and Soft Tissue Tumors of the INC from January 2008 to December 2018.

Results:
A total of 227 patients were included; 74.5% had tumors greater than 5 cm. Most patients (29.1%) were in stage IIIB at diagnosis. Age was associated with higher mortality (HR=1.01; CI95%: 1–1.02; p=0.048); tumor persistence at admission to the INC (HR=2.34; CI95%: 1.25–4.35; p=0.007), and histologic grade III (HR=5.36; CI95%: 2.29–12.56; p=<0.001) showed statistical significance in the multivariate analysis for recurrence of any type, as were the PFs associated with a higher risk of local recurrence (HR=2.85; CI95%: 1.23–6.57; p=0.014 and HR=6.09; CI95%: 2.03–18.2; p=0.001), respectively. Tumor size (HR=1.03; CI95%: 1–1.06; p=0.015) and histologic grade III (HR=4.53; CI95%: 1.42–14.49; p=0.011) were associated with a higher risk of distant recurrence.

Conclusion:
This cohort showed that in addition to histologic grade and tumor size, tumor persistence at the time of admission has an impact on disease recurrence, so STS should be managed by a multidisciplinary team with experience in this pathology in high-volume reference centers.
Prevalence of Dangerousness to Public, Criminogenic Risk Factors and Psychopathic Traits in Child-to-Parent Offenders and Contrast with Non-Child-to-Parent Offenders
Authors: Fandiño Ricardo , Basanta Juan , Fariña Francisca , Arce Ramón
Published: January 2024

Aim: Child-to-parent offenders (CPOs) are commonly specialist offenders and with high rates of recidivism. Thus, a field study was designed to estimate the prevalence in the reference measures of recidivism i.e., dangerousness, risk factors and psychopathy, and compare CPOs with non-child-to-parent juvenile offenders. Method: 136 juvenile offenders (76.5% boys), 76 CPOs and 60 non-CPOs juvenile offenders, aged from 14 to 18 years old, were measured in dangerousness, risk of factors and psychopathic traits. Results: The results showed in CPOs a more than common prevalence (> .50), 75.0%, 95% CI [.653, .847], of dangerousness (caseness); a significant prevalence (> .05) of diagnostic of psychopathy, 25.0%, 95% CI [.150, .350]; and a common prevalence (= .50), 55.3%, 95% CI [.441, .665] of classification as high and very high risk by risk factors. Comparatively, no significant differences were observed between CPOs and non-CPOS juvenile offenders in mental health problems (dangerousness), meanwhile that CPOs exhibited significant more interpersonal and affective psychopathic traits and significant more risk in family circumstances, and personality and behaviour risk factors. Conclusions: The implications for prevention and intervention programs with CPOs are discussed
Exploring Hypericin as a Potential Modulator of Key Targets in Escherichia coli
Authors: Ferrari Ivan Vito
Published: January 2024

This study employs molecular docking techniques to investigate a spectrum of targets within Escherichia coli (E. coli), with a specific focus on four key proteins: Beta-lactamase, MccE protein, Penicillin G acylase, and DNA polymerase II. The research explores the binding interactions of various natural compounds, emphasizing Hypericin. Through computational analyses, the study aims to unveil the potential interactions between these compounds and essential proteins in E. coli. Notably, Hypericin demonstrates remarkable binding energy scores of approximately -10.5 kcal/mol within the Ligand Binding Site of the specified proteins. This observation suggests Hypericin's potential as a potent modulator of E. coli targets, prompting further investigation into its antimicrobial properties and therapeutic applications.
Influence of Cu Addition on the Wear Behavior of Eutectic Al-12.6Si Alloy Developed by Spray Forming Method
Authors: Goudar Dayanand M. , Haider Julfikar , Raju K. , Kurahatti Rajashekar V. , Pinto Deesy G.
Published: January 2024

The principal main of this research work was the study the influence of Cu addition on the wear behavior (WB) of eutectic Al-12.6Si alloy developed by spray forming (SF) method and compared with as-cast (AC) alloys. The phases of chemical compositions and microstructure were studied by optical microscopy, energy dispersive spectroscopy (EDS) and Scanning Electron Microscopy (SEM). The microstructure of SFAl-12.6Si (SF1) alloy reside — of fine primary and eutectic Si phases evenly distributed in the equiaxed α-Al matrix and SF Al-12.6Si-2Cu (SF2) alloy lie of uniformly distributed fine eutectic Si particulates and spherical form θ-Al2Cu precipitates in α-Al matrix. On other hand, the AC Al-12.6Si alloy (AC1) alloy involve of eutectic Si needles in the dendrite α-Al matrix, whereas AC Al-12.6Si-2Cu (AC2) alloy consisted of eutectic Si needles and Chinese script form θ phase distributed randomly in the α-Al matrix. The microhardness and wear properties were analyzed using Vickers hardness (VH) and dry sliding WT. The SF alloys exhibit superior hardness compared to the AC alloys. The wear properties of SF alloys exhibited significantly superior compared to the AC alloys. The SF2 alloy showed high wear resistance (WR) than the SF1 alloy in the entire sliding velocities and applied loads. The results indicate that the spray deposited alloys have a lower coefficient of friction (CF(µ)) than the AC alloys under varying load and sliding velocity conditions. The high WR in the SF alloy was due to microstructural modification during SF and precipitation of fine Al2Cu intermetallic and solid solubility effects. The SF2 depicts increased transition from oxidative to abrasive. In other ways, AC alloys demonstrate wear mechanisms that change from oxidative to abrasive and delamination with an increase in sliding velocity and load.
High-Resolution Patterning of Conductive Microstructures by Electrostatic Deposition of Aerosol Au Nanoparticles through the Dielectric Mask
Authors: Efimov Alexey , Patarashvili Anton , Maslennikov Dmitry , Davydov Vladislav , Kornyushin Denis , Labutov Dmitry , Torgunakov Vitaly , Zebreva Margarita , Ivanov Victor
Published: January 2024

A new approach of electrostatically focusing nanoparticles through an electrical tape mask to form narrow <10 μm and conductive microstructures is developed and investigated in this work. The presented approach is similar to deposition of material through a stencil and allows one to obtain lines 15 times smaller than the width of the gap in the mask. It is proposed to use ordinary PVC electrical tape as a mask instead of expensive photo or electronic resists. The work investigated the influence of a mask thickness (height) of 60–180 μm, a gap width of 120–380 μm, a substrate potential of 0.1–5 kV, and a deposition time of 10 and 120 min on the geometry and electrical properties of the lines. The substrate material was Si, and charged Au nanoparticles 60 nm in size synthesized by spark discharge were the building blocks of microstructures. Numerical modeling of the process of focusing nanoparticles in COMSOL qualitatively confirmed the found experimental dependencies. The electrical resistivity of the sintered lines is 6.34 times higher than that of bulk gold. The developed approach makes it possible to obtain high-aspect microstructures, supports operation at atmospheric pressure, and is flexibly controlled in terms of the choice of materials.
Proximate Composition of Nappi and its way of marketing in Bangladesh
Authors: Monwar Md. Mostafa , Islam Md. Royhanur , Nirjar Sawmor Dey , Khan Mohammed Ashraful Azam , Alam Mohammed Shahidul , Ali Ataher , Ahmed Istiak
Published: January 2024

Nappi, fermented shrimp, a traditional diet, is widely consumed by the ethnic communities of Southeast Asian countries, especially in Bangladesh. The present study was carried out to determine the proximate composition of Nappi collected from two different places i.e., Moheshkhali and Chaufaldandi areas of Cox’s Bazar district, Bangladesh. The proximate composition of Nappi was varied from place to place depending on raw materials, preparation techniques and surrounding conditions of formulation places. Proximate composition includes moisture, protein, carbohydrate, fat and ash contents, amounting 37.66%, 34.93%, 1.39%, 8.53% and 17.49% respectively for the Moheshkhali and 35.44%, 37.43%, 2.66%, 6.0%, and 18.47% respectively for the Chaufaldandi sample. In the present study it is evident that moisture and fat content were higher in Moheshkhali sample whereas protein, carbohydrate and ash content were also higher in Chaufaldandi sample. Marketing strategy, Supply Channel, and Value Chain of Nappi were also analyzed. The findings of the study revealed that the good quality of Nappi relied on the fresh raw materials, hygienic condition of processing place and suitable techniques. Moreover, the good quality Nappi has a great market demand to the local ethnic communities in Bangladesh as well to the ethnic communities are living abroad. So, it is recommended to provide intervention on proper preparation techniques and marketing channels of Nappi.
The enhanced energy metabolism in the tumor margin mediated by RRAD promotes the progression of oral squamous cell carcinoma
Authors: Feng Zhien , Cheng Aoming , Xu Qiaoshi , Li Bo , Zhang Lirui , Wang Hao , Liu Chang , Han Zhengxue
Published: January 2024

The tumor margin as the invasive front has been proven to be closely related to the progression and metastasis of oral squamous cell carcinoma (OSCC). However, how tumor cells in the marginal region obtain the extra energy needed for tumor progression is still unknown. Here, we used spatial metabolomics and the spatial transcriptome to identify enhanced energy metabolism in the tumor margin of OSCC and identified that downregulation of Ras-related glycolysis inhibitor and calcium channel regulator (RRAD) in tumor cells mediated this process. The absence of RRAD enhanced the ingestion of glucose and malignant behaviors of tumor cells both in vivo and in vitro. Mechanically, the downregulation of RRAD promoted the internal flow of Ca2+ and hence elevated its concentration in the nucleus, which resulted in the activation of the CAMKIV-CREB1 axis to induce the transcription of the glucose transporter GLUT3. GLUT inhibitor-1, as an inhibitor of GLUT3, could suppress this vigorous energy metabolism and malignant behaviors caused by downregulation of RRAD. Taken together, our study revealed that enhanced energy metabolism in the tumor margin mediated by RRAD promotes the progression of OSCC and proved that GLUT3 is a potential target for future treatment of OSCC.
Evaluation of Online job Portals for HR Recruitment selection using AHP in Two Wheeler Automotive Industry– A case study
Authors: Murugesan Vadivel Senghazhani , Sunny Rohan
Published: January 2024

Automotive companies are booming worldwide in the economy. In order to sustain in the highly competitive world, every organization tries to create itself a trademark in the market. During the research, we looked at how two wheelers automotive company's selection and training system affected organizational performance, which together ensured the company's future growth. It ensures customer happiness, business performance, and the optimization of sales, purchasing, and logistical processes. In today's fast-paced, globally integrated world, human resources are one of the most important production variables. It is critical to preserve and improve economic competitiveness by properly selecting and developing these resources. The main aim of this study is to identify the best online job portal website for recruitment at Two Wheeler Company and to suggest an HR strategy which resonates company’s values and culture. Towards the end of the study, the researcher aims to design an efficient and effective HR strategy that can attract, engage and retain the top talent in the organization. A sample of 15 for selection of best online job portal for recruitment through proper questionnaires. Findings reveal that all the variables have a significant positive impact on the employer branding.
Social Media Analyses to Capture the Signs and Impacts of Fever Symptoms in Infants and Young Children
Authors: Smith Adam , Laughey William , Esclassan Frederic , Lodhi Imran
Published: January 2024

Purpose
Current efforts to tackle the challenges associated with managing child fevers have focused on developing an observer-report (ObsRO), the Paediatric Fever Distress Index (PFDI), which allows parents and caregivers the means to accurately recognize and treat child fevers. To further develop the PFDI, this study utilized online forums to evaluate parent-reported causes and symptoms of fever, the impact of these fevers on both children and parents, and to understand the means of parental management and diagnosis of child fevers.
Methods
Through analysis of social media and selected posts from the parental forum website Mumsnet.com, this study used natural language processing methods and a qualitative analytical approach to identify and analyze key themes relating to the study objectives in users’ posts.
Results
Gastrointestinal and respiratory symptoms were among the most frequently reported impacts of fever, whereas common causes were reported as vaccinations and viral infections. Approximately, half the parents and caregivers reported managing fever with antipyretic medication. Other parents and caregivers reported a significant emotional impact, feeling worried, scared, and panicked about their child’s fever.
Conclusion
This explorative study identified social media forums as being a rich source of information regarding parental behaviors and attitudes towards the identification and management of child fevers. Parental behaviors were varied, yet certain knowledge gaps identified the need for further education and future research into the management of fevers in children.
Clonal CD8 T Cells Accumulate in the Leptomeninges and Communicate with Microglia in Human Neurodegeneration
Authors: Elyaman Wassim , Hobson Ryan , Levy Samuel , Flaherty Delaney , Xiao Harrison , Ciener Benjamin , Reddy Hasini , Singal Chitra , Kim Christine , Teich Andrew F , Shneider Neil , Bradshaw Elizabeth
Published: January 2024

Murine studies have highlighted a crucial role for immune cells in the meninges in surveilling the central nervous system (CNS) and influencing neuroinflammation. However, how meningeal immunity is altered in human neurodegeneration and its effects on CNS inflammation is understudied. We performed the first single-cell analysis of the transcriptomes and T cell receptor (TCR) repertoire of 104,635 immune cells from 55 postmortem human brain and leptomeningeal tissues from donors with neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, and Parkinson’s disease. RNA and TCR sequencing from paired leptomeninges and brain allowed us to perform lineage tracing to identify the spatial trajectory of clonal T cells in the CNS and its borders. We propose that T cells activated in the brain emigrate to and establish residency in the leptomeninges where they likely contribute to impairments in lymphatic drainage and remotely to CNS inflammation by producing IFNγ and other cytokines. We identified regulatory networks local to the meninges including NK cell-mediated CD8 T cell killing which likely help to control meningeal inflammation. Collectively, these findings provide not only a foundation for future studies into brain border immune surveillance but also highlight important intercellular dynamics that could be leveraged to modulate neuroinflammation.
Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
Authors: Cofre Rodrigo , Castro Pablo , Tagliazucchi Enzo , Perl Yonathan Sanz , Naci Lorina , Owen Adrian , Sitt Jacobo , Destexhe Alain , Luppi Andrea
Published: January 2024

Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness induced by general anaesthesia or slow wave sleep. By clustering transient states of functional connectivity, we demonstrated that brain activity during unconsciousness is dominated by a recurrent pattern primarily mediated by structural connectivity and with a reduced capacity to transition to other patterns. Our results provide evidence supporting the pronounced differences between conscious and unconscious brain states in terms of whole-brain dynamics; in particular, that the maintenance of rich brain dynamics measured by entropy is a critical aspect of conscious awareness. Collectively, our results may have significant implications for our understanding of consciousness and the neural basis of human awareness, as well as for the discovery of robust signatures of consciousness that are generalizable among different brain conditions.
Effects of the heating strategy on the joint properties during infrared welding of polyamides
Authors: Gevers Karina , Schraa Lucas , Toews Paul , Decker Julia , Schöppner Volker , Uhlig Kai , Stommel Markus
Published: January 2024

In infrared welding, the heating phase is the phase offering the highest flexibility of choice regarding the process parameters. In this phase, the process parameters such as the heating time, emitter power and emitter component distance can be individually selected and combined with each other. The defined heating phases have a different influence on the joining components. In this work, the effects of four heating strategies and their influence on the resulting temperature distribution over the joining surface, the possible thermal material degradation, the morphology of the joining zone and the short-term tensile strength of the welded samples are investigated. In order to investigate the morphology, microsections are prepared which enable transmitted light microscopy of the black PA6 GF50 used. In summary, it can be concluded that different heating strategies have a different influence on the material even if the generated melt layer thickness is kept the same. Three of the four strategies result in material degradation on the joining surface. However, this has almost no effect on the resulting short-term strength of the weld. The results show that a high joining pressure compensates for the influence of the material damage by pressing the damaged material into the bead.