bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulating Impacts of Real-World Wind Farms on Land Surface Temperature Using the WRF Model: Validation with Observations
Authors: Xia Geng , Cervarich Matthew C. , Roy Somnath Baidya , Zhou Liming , Minder Justin R. , Jimenez Pedro A. , Freedman Jeffrey M.
Published: October 2017

This study simulates the impacts of real-world wind farms on land surface temperature (LST) using the Weather Research and Forecasting (WRF) Model driven by realistic initial and boundary conditions. The simulated wind farm impacts are compared with the observations from the Moderate Resolution Imaging Spectroradiometer (MODIS) and the first Wind Forecast Improvement Project (WFIP) field campaign. Simulations are performed over west-central Texas for the month of July throughout 7 years (2003–04 and 2010–14). Two groups of experiments are conducted: 1) direct validations of the simulated LST changes between the preturbine period (2003–04) and postturbine period (2010–14) validated against the MODIS observations; and 2) a model sensitivity test of LST to the wind turbine parameterization by examining LST differences with and without the wind turbines for the postturbine period. Overall, the WRF Model is moderately successful at reproducing the observed spatiotemporal variations of the background LST but has difficulties in reproducing such variations for the turbine-induced LST change signals at pixel levels. However, the model is still able to reproduce coherent and consistent responses of the observed LST changes at regional scales. The simulated wind farm–induced LST warming signals agree well with the satellite observations in terms of their spatial coupling with the wind farm layout. Moreover, the simulated areal mean warming signal (0.20°–0.26°C) is about a tenth of a degree smaller than that from MODIS (0.33°C). However, these results suggest that the current wind turbine parameterization tends to induce a cooling effect behind the wind farm region at nighttime, which has not been confirmed by previous field campaigns and satellite observations.
A Newly Designed Infrared Reflection Absorption Spectroscopy System for In Situ Characterization from Ultrahigh Vacuum to Ambient Pressure
Authors: Du Yunshu , Li Ling , Wang Xuan , Qiu Hengshan
Published: October 2017

We present a novel ultrahigh vacuum (UHV) compatible polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) system that is designed for in situ surface spectroscopic characterization on a transferable single crystalline sample. The innovative design of manipulator rod and high-pressure cell (HPC) ensures free movement of the sample between the preparation chamber and the HPC, and perfect separation of them during high pressure experiments. The pressure in the HPC can be varied from UHV (10−9 mbar) to ambient pressure (1000 mbar) while keeping the preparation chamber under UHV conditions. The design of the transferable sample holder and receiving stage allows precise temperature measurement and allows convenient sample changing. In situ IRRAS measurements under variable pressure and temperature can be conducted either in the conventional mode or with polarization modulation. Other surface characterization methods can also use the preparation chamber; thus, the system is endowed with the capability for systematic investigations of surface catalytic reactions. A case study of CO adsorption and oxidation on Pt(111) demonstrates the performance of the system.
Criminalising Sexual Harassment
Authors: Luzon Golan
Published: October 2017

The article explores the differences between sexual behavior in the workplace and in the public domain. Arguments against criminalising sexual harassment because of incompatibility with the principles of criminal law are shown to be inaccurate. In the labor market, the principles of criminal law are consistent with a definition of sexual harassment as an offense of strict liability, and application of the doctrine of strict liability can protect the value of equality through criminal law.
Effectiveness of Contour Augmentation with Guided Bone Regeneration: 10-Year Results
Authors: Chappuis V. , Rahman L. , Buser R. , Janner S.F.M. , Belser U.C. , Buser D.
Published: October 2017

In aesthetic sites, the integrity of the facial bone wall dimension in the anterior maxilla is jeopardized by physiologic and structural changes postextraction. An effective regenerative protocol is key to reestablish and maintain the hard and soft tissue dimensions over time. The present prospective case series study examined the effectiveness of early implant placement with simultaneous contour augmentation through guided bone regeneration with a 2-layer composite graft in postextraction single-tooth sites over an observation period of 10 y among 20 patients. The median peri-implant bone loss was 0.35 mm between the 1- and 10-y examination. A success rate of 95% was obtained, with pleasing aesthetic outcomes and a high median Pink Esthetic Score (8). Implant crowns (ICs) revealed significant median facial recession between IC10y and IC1y (0.17 mm). The facial bone wall dimensions were assessed by preoperative cone beam computed tomography and 2 subsequent scans taken at 6 and 10 y. The median facial bone wall thickness increased significantly from 0 mm at surgery to 1.67 mm at the 10-y examination. The facial vertical bone wall peak (DIC) was located at a median distance of 0.16 mm coronal to the implant shoulder. The facial vertical bone loss of DIC amounted to 0.02 mm between 6 and 10 y. Equivalence testing was performed for the null hypothesis of a difference of >0.2 mm per year between 2 respective time points, showing stable bone conditions. Modulating factors influencing the regenerative outcomes at 10 y were the preoperative proximal crest width and soft tissue thickness. In conclusion, the present study confirmed the long-term effectiveness of early implant placement with simultaneous contour augmentation through guided bone regeneration with a 2-layer composite graft in postextraction single-tooth sites offering stable bone conditions with low risks of mucosal recessions over an observation period of 10 y ( ClinicalTrials.gov NCT03252106).
Simulation and experimental investigation of vehicle braking system employing a fixed caliper based electronic wedge brake
Authors: Ahmad F , Hudha K , Mazlan SA , Jamaluddin H , Aparow VR , Yunos MR M
Published: October 2017

This paper presents an investigation into the performance of a fixed caliper based electronic wedge brake (FIXEWB) in a vehicle braking system. Two techniques were used as assessment methods, which are simulation via MATLAB Simulink software and experimental study through hardware-in-the-loop-simulation (HILS). In the simulation study, the vehicle braking system was simulated by using a validated quarter vehicle traction model with a validated FIXEWB model as the brake actuator. A proportional–integral–derivative controller was utilized as the brake torque control, whereas proportional–integral and proportional controllers were used as the position and speed control of the actuator, respectively. To study the effectiveness of the FIXEWB, the response of the vehicle using the FIXEWB is compared with the responses of a vehicle using a conventional hydraulic brake. A dynamic test, namely braking in the sudden braking at constant speeds of 40 and 60 km/h was then used as the testing method. The simulation results show that the usage of the FIXEWB with an appropriate control strategy produces similar behavior to that of a hydraulic brake in terms of the produced desired braking torque but with faster time response. To study the performance of the FIXEWB when implemented on a real vehicle, an experimental rig using HILS was designed and the results are analyzed using the same dynamic tests. The performance areas evaluated are vehicle body speed, wheel speed, tire longitudinal slip, and the stopping distance experienced by the vehicle. The outcomes from this study can be considered in the design optimization of an antilock braking system control in a real car in the future.
Shadow Capital: The Democratization of College Preparatory Education
Authors: Cipollone Kristin , Stich Amy E.
Published: October 2017

In this article, we examine the manifestation and consequences of shadow capital within two public, urban, nonselective, college preparatory–designated high schools serving exclusively nondominant students. Informed by three years of ethnographic data, we argue that the transference of a historically elite college preparatory education from dominant institutions to nondominant schools results in fundamental changes to the dominant capital it is expected to yield. Rather than generating highly valued capital within the field of education, it produces what we call “shadow capital.” As a distinct form of cultural capital, shadow capital outwardly resembles yet contains only traces of dominant cultural capital, thus failing to yield the same kind of exchange value in the postsecondary marketplace. Shadow capital offers explanatory power for the many unmet promises of educational reform and further challenges the often well-intended democratizing forces that paradoxically reinforce inequality in education.
The Worldwide Growth of Private Higher Education: Cross-national Patterns of Higher Education Institution Foundings by Sector
Authors: Buckner Elizabeth
Published: October 2017

This article investigates cross-national patterns of public and private higher education institution (HEI) foundings from 1960 to 2006. It argues that in addition to national demographic and economic factors, patterns of HEI foundings also reflect world-level models about how nations should structure their higher education systems. Findings document a rapid, recent rise in new private HEIs and point to supranational normative, mimetic, and coercive pressures that have encouraged nations to expand private higher education, including international development aid trends in peer nations, and linkages to intergovernmental organizations. I argue that while the public-sector HEI has been a long-standing and globally legitimated model for national development, private higher education has historically been associated with some world regions but not others. However, over the past two decades, supranational actors and ideas helped legitimate the private HEI as an acceptable model, spreading it even in regions that previously eschewed private higher education.
Mixed-use development in Christchurch, New Zealand: Do you want to live there?
Authors: Kusumastuti Diana , Nicholson Alan
Published: October 2017

Christchurch, one of New Zealand’s major cities, has been dealing with a housing shortage after a series of major earthquakes struck in 2010 and 2011, causing extensive damage to the city. Consequently, two distinct types of housing development appeared in the suburban areas of Christchurch: low-density single-use neighbourhoods and higher-density mixed-use neighbourhoods. The latter type is relatively new for Christchurch suburban areas where low population densities dominated prior to 2011. Thus, this study aimed to investigate the preferences of the residents of Christchurch and its surrounding districts for living in mixed-use neighbourhoods. Specifically, it sought to identify the weights that those residents place on the costs of house purchase and transport, versus neighbourhood costs associated with mixed-use development, when purchasing a residential property in the suburban areas of Christchurch. For this, a stated preference survey was developed, using the efficient design method, and mixed-logit models were estimated using the data. The results show that most of those residents prefer to live in low-density single-use neighbourhoods rather than in higher-density mixed-use neighbourhoods, and are sensitive to increases in the land price, density of development and diversity of land use in the areas.
Competitive sub-metropolitan regionalism: Local government collaboration and advocacy in northern Melbourne, Australia
Authors: Henderson Steven
Published: October 2017

In contrast with attention to city-regions as motors of the global economy, alternative perspectives indicate the rising complexity of metropolitan forms. The coherency of city-regions, their management and the intensity of political benefits from outwardly radiating opportunities can therefore be considered problematic. Symbolic of this complexity is the emergence of sub-metropolitan regions, or sub-regions within city-regions, that seek to better position themselves within global economic flows and public-sector funding allocations. Careful assessment is necessary as place-based factors, including multi-level government structures and prevailing inter-government relations, shape resulting regional governance formations. In the Australian context, the significance of the state government level and a dearth of commentary on local government advocacy are highlighted. Within expansive Melbourne, regional wedge-based forms of collaboration involving local councils are identified, some having historical equivalents and overlapping regional governance structures. Specific attention is directed towards northern Melbourne where seven local councils forged a regional collaborative approach in the early 2010s after reflecting upon local and regional experiences and the achievements of other metropolitan and Victorian regions. A ratcheting upwards of advocacy endeavours is identified as symbolised by government delegations, advocacy documents, connections between regional governance structures and deliberation over how advocacy can be made more impactful. Future research priorities include comparative investigations to better document and conceptualise local and regional advocacy approaches and experiences, plus analysis of the counterstrategies designed by higher government levels to manage competing sub-metropolitan regions.
Tangible Technology-Enhanced Learning for Improvement of Student Collaboration
Authors: Barneva Reneta P. , Gelsomini Federico , Kanev Kamen , Bottoni Paolo
Published: October 2017

Collaboration among students in the course of learning plays an important role in developing communication skills. In particular, it helps for team building and brainstorming on solutions of complex problems. While an effective group organization is critical for the success of such collaborative learning, many instructors would make arbitrary decisions about student grouping. This is mainly due to the lack of in-depth studies analyzing group setup in face-to face settings and providing recommendations and practical guidelines for group assignment and management. To address this problem, we conducted a series of experiments exploring the dynamic formation of collaborative groups among foreign language students at different proficiency levels. On the basis of the obtained results and the identified limitations of the current methods, we propose a novel technology-enhanced approach to optimized group setup and effective management. This approach provides a scaffold for integrating Tangible Technology Enhanced Learning and Computer Supported Collaborative Learning into an instructional system with advanced interaction capabilities for augmented learning and enhanced instructor support for dynamic group management.
Women’s Evolving Roles in Drug Trafficking in the United States
Authors: Anderson Tammy L. , Kavanaugh Philip R.
Published: October 2017

Drugs and crime research and theory in the United States originated after President Nixon declared the first War on Drugs in 1971. This research agenda promised to reveal the scope, dynamics, and impact of the drugs–crime relationship, thus promising solutions for the country’s drug problems. The initial focus was on drug trade violence and, as a result, produced scholarship mostly on men’s involvement in drug distribution, purchasing, and related crimes. It paid little attention to women’s involvement and failed to consider how gender might shape the drugs–crime relationship. By the early 1980s, however, studies began to appear on women’s experiences and addressed the role of gender in U.S. street-based illegal markets for crack cocaine and heroin. These studies revealed women’s relative powerlessness or supporting roles to domineering males in illegal, street-based drug markets. Today, drugs of concern in the U.S. originate and are sold and purchased through both legal and illegal channels that often work in tandem. This interplay requires us to rethink the drugs–crime relationship. Our article seeks to provoke new thinking and research on how 21st-century drug trends might reshape the gendered nature of drug selling across both legal and illegal markets and the gray area in between. In specific terms, we review the nature of women’s involvement in newer drug markets and consider how their involvement differs from that of men and how theory and research might move forward in addressing these changes. Our conclusions, and those reached by others in this issue, speak to the centrality of gender scholarship in research and policy on drugs and crime currently and into the future.
The Synoptic Problem and Statistics: A Review
Authors: Mealand David L.
Published: October 2017

This book offers an improved version of Honoré’s triple link Synoptic model. Under the assumption of Markan priority it ﬁnds new evidence for dependence between Matthew and Luke in their use of Mark. It offers a new analysis of the fact that Luke and Matthew use Mark in different ways in different sets of passages, and it sifts out those passages where evidence of dependence is most concentrated. It also analyses patterns of agreement arising where a text other than Mark is considered to be the earliest. The concluding sections offer a more literary analysis of selected passages in which Luke and Matthew agree more closely in retaining (or not retaining) words in Mark, or agree in supplying words not in Mark.
The Transformative Power of Knowledge Sharing in Settings of Poverty and Social Inequality
Authors: Qureshi Israr , Sutter Christopher , Bhatt Babita
Published: October 2017

Knowledge sharing is central to reducing inequality and alleviating poverty. However, communities in settings of extreme poverty are often bounded by distinct perspectives and understandings that hinder knowledge sharing. Furthermore, social fault lines may create internal boundaries that impede interaction, further complicating knowledge sharing. Despite these challenges, some knowledge sharing efforts are successful. The purpose of this study is to better understand how knowledge sharing overcomes boundaries in settings of extreme inequality and poverty. Using qualitative data from rural India, we find that boundary work performed by boundary spanners overcomes external and internal boundaries by creating space for action, observation, and reflection in the recipient community. These actions, or syncretizing mechanisms, transform newly introduced knowledge, which then facilitates further boundary work, resulting in community transformation. Under certain circumstances, we see how boundary work and syncretism can lead to significant knowledge and recipient transformation. Thus, we seek to contribute to the literature by more fully exploring the transformative power of knowledge sharing within contexts of extreme poverty, and by explaining the process by which it occurs.
Understanding social influence on mobile social networking sites: A social support perspective
Authors: Zhou Tao
Published: October 2017

Due to the social networking relationship, users’ continuance of social networking sites (SNS) may receive social influence from their peers and referents. This research identified the effect of social support on social influence in mobile SNS. Social support consists of both informational support and emotional support. Social influence is reflected by three factors: subjective norm, social identity and group norm. The results suggested that social support has a significant effect on social influence. The results imply that service providers need to build a supportive climate in order to facilitate social influence and users’ continuance usage.
Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists
Authors: Higgins Guy A , Zeeb Fiona D , Fletcher Paul J
Published: October 2017

The selective 5-HT2C receptor agonist lorcaserin entered clinical obesity trials with the prevalent view that satiety was a primary mechanism of action. Subsequent Phase II and III trials demonstrated efficacy in terms of weight loss, although the overall effect size (~3% placebo-corrected change) is considered modest. Lorcaserin has been approved by the FDA for the treatment of obesity with lifestyle modification, but since its introduction in 2013 its sales are in decline, probably due to its overall modest effect. However, in some individuals, lorcaserin has a much more clinically significant effect (i.e. >10% placebo-corrected change), although what common features, if any, define these high responders is presently unknown. In the present article we highlight the evidence that alternative mechanisms to satiety may contribute to the anti-obesity effect of lorcaserin, namely effects on constructs of primary and conditioned reward and impulsivity. This may better inform the clinical evaluation of lorcaserin (and any future 5-HT2C receptor agonists) to subgroups of obese subjects characterized by overeating due to maladaptive impulsivity and reward mechanisms. One such population might be individuals diagnosed with binge eating disorder.
Sex differences in estimated brain metabolism in relation to body growth through adolescence
Authors: Vandekar Simon N , Shou Haochang , Satterthwaite Theodore D , Shinohara Russell T , Merikangas Alison K , Roalf David R , Ruparel Kosha , Rosen Adon , Gennatas Efstathios D , Elliott Mark A , Davatzikos Christos , Gur Ruben C , Gur Raquel E , Detre John A
Published: October 2017

The human brain consumes a disproportionate amount of the body’s overall metabolic resources, and evidence suggests that brain and body may compete for substrate during development. Using perfusion MRI from a large cross-sectional cohort, we examined developmental changes of MRI-derived estimates of brain metabolism, in relation to weight change. Nonlinear models demonstrated that, in childhood, changes in body weight were inversely related to developmental age-related changes in brain metabolism. This inverse relationship persisted through early adolescence, after which body and brain metabolism began to decline. Females achieved maximum body growth approximately two years earlier than males, with a correspondingly earlier stabilization of brain metabolism to adult levels. These findings confirm prior findings with positron emission tomography performed in a much smaller cohort, demonstrate that relative brain metabolism can be inferred from noninvasive MRI data, and extend observations on the associations between body growth and brain metabolism to sex differences through adolescence.
Removal of Hg, As in FGD gypsum by different aqueous ammonia (amines) during CO2 sequestration
Authors: Wenyi Tan , Wenhui Fan , Hongyi Li , Zixin Zhang , Yunkun Zhu
Published: October 2017

CO2 sequestration by flue gas desulfurization gypsum (FGDG) has become a promising FGDG disposal technology due to simultaneous CO2 emission reduction and FGDG conversion into calcium carbonate. In this paper, another merit of the novel technology, i.e., the removal of toxic elements (e.g., Hg and As) in FGDG, will be addressed for the first time. In three different aqueous ammonia (or amines) media, removal efficiencies of Hg and As in FGDG samples were evaluated during CO2 sequestration. Higher than 90% and 20% removal efficiencies, respectively, for Hg and As are achieved at 40°C in aqueous ammonia media, but they decrease at elevated temperatures. Ammonia loss takes place at 80°C and pH varies greatly with temperatures in aqueous ammonia. This is disadvantageous for the formation of Hg–ammonia complexes and for the yield of carbonates, which are responsible for Hg or As re-adsorption. The sequential chemical extraction method suggests that the speciation changes of Hg are induced by FGDG carbonation, and that unstable Hg speciation in triethanolamine increases at elevated temperatures.
Development of a Game-Based Learning Judgment System for Online Education Environments Based on Video Lecture: Minimum Learning Judgment System
Authors: Jo Jaechoon , Yu Wonhui , Koh Kyu Han , Lim Heuiseok
Published: October 2017

We propose a minimum learning judgment system that is appropriate for online learning environments, and we verify this minimum learning judgment system through various experiments. By focusing on the learning effort, this system can easily and quickly determine whether learners have exerted the minimum effort required for learning. To do this, the system automatically generates a word game and determines whether minimum learning has taken place through the results of the word game. To verify the minimum learning judgment system, we conducted a comparative experiment on the importance of high-frequency words, a word count verification test for word games, and a judgment criteria verification test based on the length of a video lecture. Results of the experiments show that high-frequency words can be used as a feature to determine minimum learning. The appropriate number of words in the word game for the minimum learning judgment was found to be seven, and the results showed that the video length did not affect the minimum learning criteria. In addition, the minimum learning judgment accuracy result was 82%. This is not considered very high judgment accuracy, but the accuracy of the judgment is positive considering the aim of this study.
François Leuret: the last moral therapist
Authors: Brown Edward M
Published: October 2017

By the 1840s French psychiatrists had abandoned Moral Treatment as an individual psychological therapy, as opposed to an institutional practice. One advocate of Moral Treatment, however, would not go along with this movement. In three books and several papers published between 1834 and 1846, François Leuret (1797–1851) advocated aggressive psychological treatment. Recent commentators have understandably concentrated on the controversies surrounding Leuret’s practices. What such an approach has failed to make clear, however, is that Leuret had a complex, systematic psychological theory supporting his clinical judgements. In addition to reviewing the controversies that surrounded Leuret, this paper spells out Leuret’s psychological theory and shows how he used this theory to think about the individual psychotherapy he provided for his patients.
Sir Winston Churchill’s doctors on the Riviera 1949–1965: Herbert Robert Burnett Gibson (1885–1967) and Dafydd (David) Myrddin Roberts (1906–1977)
Authors: Griffiths Richard W
Published: October 2017

In May 1940, Sir Charles McMoran Wilson (later Lord Moran) was on the instigation of Lord Max Beaverbrook and Brendan Bracken, (both patients, then friends of Wilson) introduced to Winston Churchill. Thereafter, he remained Churchill’s personal physician until Churchill’s death. In his controversial book detailing Winston Churchill’s health, Lord Moran refers briefly to two doctors resident in Monaco, who were involved in the management of Churchill’s declining health from 1949. One was Scottish, Herbert Robert Burnett Gibson and the other Welsh, Dafydd Myrddin Roberts. The military and civilian careers of these doctors are profiled here.
Ibn Mandevaih Isfahani (949–983(?) AD), a physician from Isfahan’s medical school
Authors: Farkhondehzadeh Mahboobeh , Golshani Seyyed Alireza , Sanaye Mohammad Reza , Daneshfard Babak
Published: October 2017

There have arisen a number of prominent Iranian-Islamic physicians throughout the history of the fertile medicine landscape of Iran, some of whom are not very well known. Abu Ali Ahmad ibn Abd al-Rahman Mandevaih Isfahani (949–983(?) AD) was a great medical figure with scientific activities in the Hospital of Isfahan and al-Adudi Hospital of Baghdad in the golden age of Iranian-Islamic history, culture, and civilization during the reign of the Buyid dynasty and Abbasid Caliphate. He was also a prominent physician during the reign of Adud al-Dawla Deylami (949–983 AD). This present research has as its objectives the studying of the scientific life of ibn Mandevaih Isfahani and his works in this field. The works of this scientist and scholar reflect his skill and expertise in literature, philosophy, medicine, and medicine-related fields including ophthalmology and pharmacology.
Glycoprotein CA19.9-specific monoclonal antibodies recognize sialic acid–independent glycotope
Authors: Chugh Manoj , Piskarev Vladimir , Galanina Oxana , Khasbiullina Nailya , Kadam Pallavi , Shilova Nadezhda , Pazynina Galina , Dobrochaeva Kira , Bhanushali Paresh , Kozlov Nikolay , Tupitsin Nikolay , Bovin Nicolai
Published: October 2017

A repertoire of monoclonal antibodies was generated by immunization of mice with cancer-associated glycoprotein CA19.9, and two of them were selected as optimal capture and detecting counterparts for sandwich test system for detection of CA19.9. Fine epitope specificity of the antibodies was determined using printed glycan array, enzyme-linked immunosorbent assay, and inhibitory enzyme-linked immunosorbent assay. Unexpectedly, both immunoglobulins did not bind key epitope of CA19.9 glycoprotein, tetrasaccharide SiaLeA, as well as its defucosylated form sialyl LeC (known as CA-50 epitope). The antibodies were found to have different glycan-binding profiles; however, they recognized similar glycotopes with common motif Galβ1-3GlcNAcβ (LeC), thus resembling specificity of human natural cancer-associated anti-LeC antibodies. We propose that cancer-specific glycopeptide epitope includes Galβ1-3GlcNAcβ fragment of a glycoprotein O-chain in combination with proximal hydrophobic amino acid(s) of the polypeptide chain.
Composite Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia and Follicular Lymphoma: A Clinicopathological Study of Six Cases
Authors: Jelloul Fatima Zahra , Chen Qiang Hua , Yang Tianyu , Haghi Nina , Brody Judith , Zhang Xinmin , Sheikh-Fayyaz Silvat
Published: October 2017

Background: Composite small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) and follicular lymphoma (FL) is extremely rare, and only 13 cases have been reported previously. Methods: We identified 6 cases of composite SLL/CLL and FL in our database and studied their clinical, histologic, immunophenotypic, and cytogenetic features. A literature review of the existing cases was also conducted. Results: The patients included 4 males and 2 females, with a median age of 72 years. Four patients presented with lymphadenopathy and 2 with extranodal diseases. Lymphocytosis was seen in 2 cases. Serum lactate dehydrogenase levels were within normal range in all but one case. There were 2 histologic patterns: SLL/CLL predominant pattern (type I) and FL predominant or mixed pattern (type II). The type I pattern was exclusively associated with in situ follicular neoplasia (ISFN). The SLL/CLL showed typical morphology and immunophenotype in all the cases. The FL component included low grade (n = 3), ISFN (n = 2), and primary cutaneous FL (n = 1). Four cases had staging bone marrow biopsies including 3 cases with involvement by SLL/CLL and 1 case with involvement by SLL/CLL and FL. Four patients received treatments, one was under clinical surveillance, and one had no available information. All patients were alive after a median follow-up of 22 months. Conclusions: This is the largest case serial of composite SLL/CLL and FL. The CL affects elderly individuals, presents with advanced clinical stage, and appears to have a relatively indolent clinical course.
Modifications of Antiepileptic Drugs for Improved Tolerability and Efficacy
Authors: Landmark Cecilie Johannessen , Johannessen Svein I.
Published: October 2017

Introduction

A large number of antiepileptic drugs (AEDs) are available today, but they may not be satisfactory regarding clinical efficacy, tolerance, toxicity or pharmacokinetic properties. The purpose of this review is to focus upon the rationale behind the chemical modifications of several recently marketed AEDs or drugs in development and to categorize them according to the main purposes for the improvements: better efficacy or tolerability accompanied by improved pharmacokinetic properties.

Material and Method

AEDs that have been chemically modified to new derivatives during the last years are reviewed based on recent publications and PubMed-searches.

Results and Discussion

Improvement in pharmacokinetic parameters may affect both tolerability and efficacy. Modifications to improve tolerability include various valproate analogues, divided into aliphatic amides, cyclic derivatives or amino acid conjugates. Furthermore, there are the carbamazepine analogues oxcarbazepine and eslicarbazepine, the felbamate analogues fluorofelbamate and carisbamate (RWJ 33369), and the lamotrigine analogue JZP-4. The levetiracetam analogues brivaracetam and seletracetam and the derivatives of gabapentin, pregabalin and XP13512, have improved selectivity compared to their parent compounds. Other new drugs have new mechanisms of action related to GABA and glutamate receptors; the glutamate antagonists like topiramate (talampanel and NS-1209), and GABAA receptor agonists, benzodiazepine or progesterone analogues (ELB-139 and ganaxolone).

Conclusion

Further challenges for development of new AEDs include investigations of target molecules affected by pathophysiological processes and detailed structure-activity relationships with focus on stereoselectivity. These potential drugs may become of importance in future drug therapy in epilepsy and other CNS disorders.
Development and Retrospective Clinical Assessment of a Patient-Specific Closed-Form Integro-Differential Equation Model of Plasma Dilution
Authors: Atlas Glen , Li John K-J , Amin Shawn , Hahn Robert G
Published: October 2017

A closed-form integro-differential equation (IDE) model of plasma dilution (PD) has been derived which represents both the intravenous (IV) infusion of crystalloid and the postinfusion period. Specifically, PD is mathematically represented using a combination of constant ratio, differential, and integral components. Furthermore, this model has successfully been applied to preexisting data, from a prior human study, in which crystalloid was infused for a period of 30 minutes at the beginning of thyroid surgery. Using Euler’s formula and a Laplace transform solution to the IDE, patients could be divided into two distinct groups based on their response to PD during the infusion period. Explicitly, Group 1 patients had an infusion-based PD response which was modeled using an exponentially decaying hyperbolic sine function, whereas Group 2 patients had an infusion-based PD response which was modeled using an exponentially decaying trigonometric sine function. Both Group 1 and Group 2 patients had postinfusion PD responses which were modeled using the same combination of hyperbolic sine and hyperbolic cosine functions. Statistically significant differences, between Groups 1 and 2, were noted with respect to the area under their PD curves during both the infusion and postinfusion periods. Specifically, Group 2 patients exhibited a response to PD which was most likely consistent with a preoperative hypovolemia. Overall, this IDE model of PD appears to be highly “adaptable” and successfully fits clinically-obtained human data on a patient-specific basis, during both the infusion and postinfusion periods. In addition, patient-specific IDE modeling of PD may be a useful adjunct in perioperative fluid management and in assessing clinical volume kinetics, of crystalloid solutions, in real time.
Influence of Wrist Position on the Metacarpophalangeal Joint Motion of the Index Through Small Finger
Authors: Latz David , Koukos Christos , Boeckers Petra , Jungbluth Pascal , Schiffner Erik , Kaufmann Robert , Gehrmann Sebastian Viktor
Published: October 2017

Background: The metacarpophalangeal joints exhibit range of motion that is influenced by wrist position. Synergistic motion occurs between the wrist and the metacarpophalangeal joints with different static wrist positions affecting joints’ motion capability. The aim of this study was to determine how different wrist positions influence the active range of motion of the index through small finger metacarpophalangeal joints. Methods: The active range of motion of the index through small finger metacarpophalangeal joints of 31 healthy subjects was measured in flexion/extension and radial/ulnar deviation in 5 different flexion/extension wrist positions, using biaxial electrogoniometers. Results: There was a difference in range of motion of all fingers depending on the wrist position. The minimum metacarpophalangeal joint range of motion was found in 80° wrist extension, the maximum in neutral wrist position. For the index finger, flexion/extension was 84.7° (±8.6°) to 25.9° (±10.2°) and radial/ulnar deviation was 32.1° (±11.3°) to 22.6° (±12.8°). For the middle finger, flexion/extension was 84.8° (±8.5°) to 25.9° (±10.1°) and radial/ulnar deviation 28.8° (±11.1°) to 22.1° (±8.9). The fourth finger showed a range of motion for flexion/extension of 87.2° (±11.5°) to 22.8° (±11.6°) and radial/ulnar deviation of 8.1° (±5.8°) to 32.3° (±12.4°). The highest range of motion was measured at the fifth finger with flexion/extension of 84.0° (±8.6°) to 32.1°(±16.8°) and radial/ulnar deviation of 15.1° (±12.9°) up to 54.6° (±18.7°). Conclusions: The range of motion of the index through small finger metacarpophalangeal joints was significantly influenced by wrist position. The highest metacarpophalangeal joint range of motion of all fingers was conducted in neutral wrist positions. Apart from ergonomic implications, we conclude that metacarpophalangeal joint motion should be assessed under standardized wrist positions.
Putting Broadcast News in Context
Authors: Abdenour Jesse , McIntyre Karen , Dahmen Nicole Smith
Published: October 2017

Contextual journalism calls for depth of news reporting rather than “just the facts.” A national survey of local television (TV) journalists indicated the increasing popularity of this more comprehensive reporting form. Although news sociologists contend that local TV routines facilitate the production of quick, less substantive stories, TV respondents in the present study highly valued comprehensive, contextual news styles—even more than newspaper journalists. Building on the work of Weaver and colleagues’ “American Journalist” project, TV news workers in this survey preferred contextual roles, such as alerting the public of potential threats and acting in a socially responsible way, but also valued traditional broadcasting roles, such as getting information to the public quickly. TV news roles were compared to those of newspaper journalists to analyze how professionals in different media view their work identities.
Acetaminophen Reduces Distrust in Individuals With Borderline Personality Disorder Features
Authors: Roberts Ian D. , Krajbich Ian , Cheavens Jennifer S. , Campo John V. , Way Baldwin M.
Published: October 2017

People with borderline personality disorder (BPD) tend to distrust others. We hypothesized that acetaminophen might reduce distrust in people with high BPD features because disordered affective responses are partially responsible for the interpersonal difficulties of people with BPD features, and acetaminophen has been shown in multiple studies to reduce negative affect. Using a double-blind, parallel-arm design, 284 young adult participants were administered either acetaminophen (1,000 mg; acute) or placebo and subsequently completed an economic trust game. BPD features were assessed with the Personality Assessment Inventory–Borderline Features scale. Participants with elevated BPD features showed less trust in their partners in the placebo condition but increased trust in the acetaminophen condition. Acetaminophen did not change expectations of trustee’s trustworthiness and did not impact trusting behavior in participants low in BPD features. Our results indicate that acetaminophen may reduce the behavioral distrust exhibited at high levels of BPD features.
Radiological analysis of minimal safe distance and optimal screw angle to avoid facet violation in open-door laminoplasty using precontoured plate
Authors: Min Woo-Kie , Seo Il , Na Sang-Bong , Choi Young-Seo , Choi Ji-Yeon
Published: October 2017

Purpose:

This study aimed to present radiologic analysis of minimal safe distance (MSD) and optimal screw angle (OSA) that enables to fix screws in a lateral mass safely without facet joint violation in open-door laminoplasty using a plate.

Methods:

A retrospective analysis was made of 22 patients (male: 17; female: 5), average age 62 years. Seventy-nine lateral mass screws were fixed among a total of 158 screws. MSD that doesn’t allow 5-mm screws to violate a facet joint was measured for C3–C7 and a comparative analysis was performed. If the MSD is not secured, the OSA to be given to the cephalad direction is calculated to avoid violation of the facet joint.

Results:

The screws violating inferior facet joints accounted for 34.1% of the screws fixed in inferior lateral mass. Joint surface to distal mini-screw distances were 3.18 ± 1.46 mm and 4.75 ± 1.71 mm in groups of facet joint violation and non-facet violation (FV), respectively ( p = 0.001). When 5-mm screws were inserted into a lateral mass, MSD was 4.39 ± 0.83 mm. The average MSD of C3, C4, and C5 was 4.05 ± 0.78 mm, 4.10 ± 0.70 mm, and 4.26 ± 0.74 mm, respectively. There was no significant differences among levels ( p > 0.05). The average MSD of C6 and C7 was 4.92 ± 0.81 mm and 4.80 ± 0.96 mm, respectively, showing significant differences from those of C3, C4, and C5 ( p < 0.05). If 6 mm of the MSD isn’t secured, OSA showed in the cephalad direction of 11.5° for 5 mm and 22° for 4 mm approximately.

Conclusion:

We suggest that mini-screw on lateral mass can be fixed safely without FV, if they are fixed at MSD of 6 mm from a joint surface. Facet joint violation doesn’t occur if an OSA is given in the cephalad direction in case of not enough MSD for mini-screws.
The Frugal Innovation Case of Solar-powered Automated Teller Machines (ATMs) of Vortex Engineering in India
Authors: Agarwal Nivedita , Brem Alexander
Published: October 2017

Constraint-based innovations are innovations that are conceived under conditions of scarcity for resource-constrained markets, often referred to as Bottom of pyramid (BoP) marketplace. One such type of constraint-based innovation, frugal innovation (also the focus of this study) has played an important role in providing affordable and accessible products and services to the customers at BoP. This study examines one of the successful frugal innovations from the Indian financial sector called Vortex solar based transaction systems (commonly known as rural ATMs) and offers a comprehensive analysis on the incorporated bottom-up product development process and innovation drivers. Study highlights the nine specific innovative design features of these machines that were mainly designed based on core customer requirements and unique challenges. Analysis reveals the importance of cost effective, easy to operate and sustainable solutions for customers at BoP and also showcase how frugal innovations are also facilitating solutions to address larger societal problems.
Endogenous fibrinolysis facilitates clot retraction in vivo
Authors: Samson Andre L. , Alwis Imala , Maclean Jessica A. A. , Priyananda Pramith , Hawkett Brian , Schoenwaelder Simone M. , Jackson Shaun P.
Published: October 2017

Key Points

Localized vascular injury with thrombin microinjection produces a fibrin network that undergoes myosin IIa–dependent retraction in vivo. Using this model, we demonstrate that endogenous fibrinolysis promotes fibrin clot retraction.
EBV latent membrane protein 2A orchestrates p27kip1 degradation via Cks1 to accelerate MYC-driven lymphoma in mice
Authors: Fish Kamonwan , Sora Richard P. , Schaller Samantha J. , Longnecker Richard , Ikeda Masato
Published: October 2017

Key Points

LMP2A enhances MYC expression, resulting in the rapid degradation of the p27kip1 tumor suppressor via Cks1, a member of the SCFSkp2 complex. Loss of Cks1 restores levels of the p27kip1 tumor suppressor and prolongs LMP2A-mediated lymphomagenesis.
Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial
Authors: Bartlett Nancy L. , Costello Brian A. , LaPlant Betsy R. , Ansell Stephen M. , Kuruvilla John G. , Reeder Craig B. , Thye Lim S. , Anderson Daniel M. , Krysiak Kilannin , Ramirez Cody , Qi Jing , Siegel Barry A. , Griffith Malachi , Griffith Obi L. , Gomez Felicia , Fehniger Todd A.
Published: October 2017

Key Points

Ibrutinib has modest activity in FL with low response rates in rituximab-refractory patients. CARD11 mutations predict for lack of response to ibrutinib.
Multisource encoding and decoding using the signal apparition technique
Authors: Amundsen Lasse , Andersson Fredrik , van Manen Dirk-Jan , Robertsson Johan O. A. , Eggenberger Kurt
Published: October 2017

Signal apparition is a method for encoding sources in simultaneous multisource seismic acquisition and decoding the multisource response of the earth into its single-source responses. For [Formula: see text] sources, encoding is performed by applying periodic sequences of period [Formula: see text] to each of the sources along source lines. Decoding is achieved in the wavenumber domain for each frequency by solving an [Formula: see text] linear system of equations. The system’s matrix is the product of a Fourier matrix and an encoding matrix, the latter containing the information of the codes. The solution of the system is unique when the encoding matrix is invertible. When the encoding sequences consist of time delays applied to sources’ firing times, the determinant of the encoding matrix becomes a polynomial. A unique solution to decoding then exists if the roots of the polynomial avoid the unit circle. Periodic time-shift sequences for two, three, four, and six sources are discussed. A model example of simultaneous four-source data acquisition illustrates the performance of the encoding/decoding technique for the spatially nonaliased case.
Random noise attenuation by planar mathematical morphological filtering
Authors: Huang Weilin , Wang Runqiu
Published: October 2017

Improving the signal-to-noise ratio (S/N) of seismic data is desirable in many seismic exploration areas. The attenuation of random noise can help to improve the S/N. Geophysicists usually use the differences between signal and random noise in certain attributes, such as frequency, wavenumber, or correlation, to suppress random noise. However, in some cases, these differences are too small to be distinguished. We used the difference in planar morphological scales between signal and random noise to separate them. The planar morphological scale is the information that describes the regional shape of seismic waveforms. The attenuation of random noise is achieved by removing the energy in the smaller morphological scales. We call our method planar mathematical morphological filtering (PMMF). We analyze the relationship between the performance of PMMF and its input parameters in detail. Applications of the PMMF method to synthetic and field post/prestack seismic data demonstrate good performance compared with competing alternative techniques.