bluuebunny/crossref_metadata_2025 huggingface dataset:
Identificación de Hipoplasia Cerebelar en gestante de 35,6 semanas, a propósito de un caso
Authors: Silva Gutiérrez Paola Alejandra , Cajas Lema Carlos Luis , Sola Villalva María Victoria , Silva Poaquiza Violeta Alexandra , Zambrano Zambrano Michelle Lissette
Published: May 2023

La hipoplasia cerebelar se asocia a una amplia variedad de características neuro-radiológicas, lo cual representa un gran desafío para los médicos que identifican estos casos, principalmente en etapa prenatal.

Objetivo. Describir un caso clínico de hipoplasia cerebelar identificado en periodo prenatal y analizar el protocolo de atención aplicado en el primer nivel de salud para embarazadas de alto riesgo.

Material y métodos. Estudio descriptivo y retrospectivo, presentación de caso clínico.

Resultados. Se presenta un caso clínico de una paciente femenina de 43 años, gestante de 35,6 semanas, sin antecedentes de importancia, que acude a primer nivel de atención por su cuarto control prenatal, asintomática, Score mama de cero puntos, se evidencian obesidad grado 1, al examen físico paciente gestante, activa, afebril, cabeza y órganos de los sentidos sin patología aparente, cardiopulmonar normal, abdomen útero gestante, altura uterina 32cm, FCF 149 lpm, feto único pelviano, región inguinogenital no se evidencia sangrado ni secreción vaginal. Además, presenta ecografía del tercer trimestre con hallazgos morfológicos patológicos de Hipoplasia de cerebelo, es referida a segundo nivel de atención para seguimiento y elección de tratamiento acorde al caso.

Conclusión. La atención brindada sigue parámetros de captación y manejo de las embarazadas de alto riesgo según las guías del ministerio de salud, sin embargo, es importante que las pacientes decidan cumplir con las recomendaciones de los médicos en primer nivel, para evitar complicaciones a futuro.
Asociación entre calidad de vida laboral y estilo de vida en personal de enfermería
Authors: Trejo Ortíz Perla María , Esparza Flores Elvira , Zorrilla Martínez Laura Berenice , Valdéz Esparza Gricelda , Calderón Ibarra Alejandro
Published: May 2023

La singularidad y contexto del trabajo en profesionales del área de la salud, los hace más vulnerables a percibir de manera no satisfactoria su calidad de vida laboral afectando su desempeño y productividad, trastocando el ámbito personal; por lo que el presente estudio se realizó con el objetivo de identificar la asociación entre calidad de vida profesional y estilo de vida en personal de enfermería, a través de un estudio correlacional, comparativo de corte transversal en 111 enfermeros(as) trabajadores de un hospital público de Zacatecas, México. Se aplicaron los cuestionarios de Calidad de Vida Profesional (CPV-35) y el instrumento de Prácticas y Creencias sobre Estilos de Vida. En una escala del 0 al 100, el estilo de vida obtuvo una media de 58.64 puntos (DE = 14.31) y la calidad de vida profesional de 62.38 (DE = 10.87), con asociación positiva y significativa entre ambas variables (r = .320, p=.01). Las personas de menor edad, con menor antigüedad laboral y escolaridad más baja, fueron quienes presentaron estilos de vida menos saludables. Es necesario implementar estrategias para mejorar el ambiente laboral y personal de estos profesionistas, quienes al ser los principales promotores de la salud, debieran predicar con el ejemplo.
Diagnóstico del arbolado Urbano en la Ciudad de Ibarra, como base para una gestión de arbolado más humano
Authors: Garrido Aguilar Lenin Fernando , Carvajal Benavides José Gabriel , Valencia Valenzuela Xavier Germán , Varela Molina Ing. Eliana Meliza , Cuarán Guerrero Milton Jimmy
Published: May 2023

El arbolado urbano brinda diversos bienes y servicios en beneficio de los habitantes de la urbe y al ambiente, por tal razón es imperativo conocer el estado de la silvicultura urbana de la ciudad de Ibarra, con un enfoque y proyección a ciudad más sostenible, mejorando los aspectos del paisaje y disminución de pérdidas económicas por daños mecánicos a terceros y a la población, así como dificultades sociales en el área de salud psíquica y contribuir a mitigar los problemas ambientales frente al cambio climático. El objetivo del presente estudio fue realizar un muestreo diagnóstico del arbolado urbano en dos parques centrales de la ciudad de Ibarra, mediante el registro de un censo de los árboles mayores a 10 cm de Diámetro a la Altura del Pecho (DAP), así se determinó el estado biomecánico y fitosanitario a través de la aplicación metodológica de Evaluación Visual del Arbolado (EVA). Se identificó 119 sujetos pertenecientes a 25 familias y 34 géneros, a través del reconocimiento de las muestras botánicas en el Herbario de la Universidad Técnica del Norte. Predomina la presencia de especies exóticas, el arbolado presenta en un 58% el estado fitosanitario con grado de riesgo, un 40,3% árboles exhiben afectación por desgarre y desmembramientos de ramas por acción antrópica y bioclimática, el 33,6% presentan plagas y/o enfermedades, el efecto diana es moderado y alto en un 42,9%, en tal sentido se concluye que deben ser intervenidos con criterio técnico de silvicultura urbana, para disminuir el grado de riesgo y la probabilidad de accidentes causados por daños biomecánicos. Además, la deficiente gestión del arbolado urbano público y baja cultura forestal urbana, hace que los sujetos forestales estudiados presenten incidencias fitosanitarias.
La tecnocultura digital en la enseñanza-aprendizaje
Authors: Morales Cordero Carlos Andrés , Viloria Espitia Jairo Miguel
Published: May 2023

En el presente artículo resulta de gran utilidad determinar la incidencia que ejerce la Tecnocultura digital en la educación cuando es parte de las herramientas de que se valen los educadores para realizar su trabajo. Dicha incidencia se estudia, para el caso de la presente investigación,  caracterizado por la globalización que ha involucrado a todas o casi todas las comunidades humanas en un mismo momento de la historia universal, posibilitado este fenómeno histórico ante todo por el inusitado desarrollo de las tecnologías informáticas, al punto de que los más recientes inventos casi inmediatamente recorren todo el planeta; lo que permite que desde la más grande metrópoli hasta la aldea más apartada conozcan en cuestión de días los últimos inventos, lo que actualmente se llama sociedad del conocimiento y cómo su evolución, producto de la tecnología, ha abarcado distintas áreas, permitiendo innovar en la educación, estimulando la creación de nuevos conocimientos, de esta manera se describe la importancia de cada agente educativo (docente-alumno) y su rol transformador en el proceso de enseñanza-aprendizaje.
Aprendizaje en la educación digital en una Institución Educativa de Ecuador
Authors: Guale Santistevan Jessenia , Vélez Ramírez Gloria Elizabeth , Rodríguez Yagual Cristhian Antonio , Vélez Ramírez Próspero Alberto
Published: May 2023

El presente manuscrito tiene como fin fundamental viabilizar los medios tecnológicos mediante técnicas de aprendizaje digitales que se validan con su respectivo constructo en cada una de las variables de investigación. Para el desarrollo de este trabajo se utilizó materiales y métodos, el tipo de investigación es de carácter descriptivo con enfoque cuantitativo, aplicando los métodos deductivo e inductivo. La técnica que se aplicó es la encuesta con el fin de obtener la información de los docentes y estudiantes del nivel de Básica Superior, que fue validada por expertos, valorada con una rúbrica, diseñada con el coeficiente de la V de Aiken y al obtener los resultados se procedió a la constatación de fiabilidad con el coeficiente del Alfa de Cronbach, para proceder a la discusión correlacionando ambas variables obteniendo resultados positivos para una posible propuesta de implementar un manual de las técnicas de aprendizaje digital con sus respectivas herramientas digitales
Aplicaciones móviles en el proceso de Enseñanza Aprendizaje de las Matemáticas
Authors: Moreira- Barre Fresia , Anzules-Pareja Mayra , Solís-Zambrano Ramón , Santos-Arguello Narcisa , Rodríguez Pierre Ascencio
Published: May 2023

Las herramientas tecnológicas han transformado el mundo educativo, sin embargo, en la práctica, son pocos los docentes que emplean estos recursos para favorecer el proceso de enseñanza aprendizaje de las matemáticas. El presente estudio se realizó con el propósito de evaluar la percepción sobre el uso de aplicativos móviles en el proceso de enseñanza aprendizaje de las matemáticas en una institución educativa de Guayaquil. La metodología empleada fue de paradigma positivista, enfoque cuantitativo. El tipo de investigación fue descriptiva-de campo, con un diseño no experimental-transaccional. Se utilizo una encuesta como técnica de recolección de datos, mediante un cuestionario con 10 preguntas. La muestra estuvo conformada por la totalidad de los estudiantes de 5to grado la institución educativa (35) y los docentes de matemáticas (6) por lo que se empleó un muestreo censal. Los datos fueron procesados mediante la estadística descriptiva. Los resultados revelaron que los docentes de matemáticas están dispuestos a la adopción de aplicaciones como parte de sus métodos, pero no se encuentran capacitados con estrategias diseñadas para el seguimiento de resultados en dichas plataformas móviles; desde el enfoque estudiantil prevalece el entusiasmo, pero cierta resistencia ante la escasa motivación que reciben.
Un breve Análisis de Vulnerabilidades en dispositivos IOT en Ecuador
Authors: Jumbo Edison , Llumiquinga Jefferson , Uyaguari Fernando , Tenezaca Andrés , Pazmiño Leandro , Rivera Richard
Published: May 2023

Este trabajo presenta un breve análisis de vulnerabilidades en dispositivos del Internet de las cosas (IoT) en Ecuador, mediante el desarrollo de una herramienta de software que busca direcciones IPv4 que están dentro del rango del territorio ecuatoriano y analiza los puertos de comunicación comunes de estas direcciones observando si dichos puertos están activos o abiertos exponiendo información sensible. Los resultados obtenidos durante el proceso de búsqueda de direcciones IPv4 han sido satisfactorios, encontrando información como: cámaras web, servidores Apache, páginas web e incluso petición de credenciales para acceder a la configuración de un router, con estos resultados se refleja que el nivel de seguridad informática en el Ecuador se encuentra en un nivel bajo. Considerando que Pichincha y Guayas, son las dos provincias más grandes del Ecuador, tienen la mayor cantidad de direcciones IPv4 con puertos activos y la mayor cantidad de exposición de información sensible sin medidas de seguridad.
Analgesia Postoperatoria personalizada en el manejo del dolor en Pacientes Quirúrgicos, Hospital Público de Chachapoyas
Authors: Pérez Caballero Laura Soledad , Silva Díaz Yshoner Antonio , Mendoza Quijano Elito , Ramos Chuquimbalqui Rolando , Ordinola Ramírez Carla María , Pizarro Salazar Oscar
Published: May 2023

Investigación cuantitativa, experimental, prospectivo y longitudinal que tuvo como objetivo determinar la efectividad de la analgesia postoperatoria personalizada en el manejo del dolor en pacientes quirúrgicos, hospital público de Chachapoyas, se utilizó una muestra de 72 pacientes intervenidos quirúrgicamente, se recolectó los datos mediante la Escala visual análoga del dolor (EVA), que evalúa de 0 a 10 puntos y se analizó mediante ANOVA para medidas repetidas. Se encontró que la edad más predominante fue entre 64-70 años con 27.8%, el 62.5% fueron de sexo masculino, el 43.1% fueron intervenidos de colecistectomía siendo este el mayor porcentaje y el 58.3% fueron tratados en el postoperatorio con anestésicos locales, las puntuaciones de la intensidad del dolor a las 12 horas del manejo con analgesia personalizada durante el postoperatorio (x̄ = 6.85; σ= 1.057) fueron mayores a las de 24 horas del postoperatorio (x̄ = 4.69; σ= 0.642; p <0.001; IC 95% [1.797- 2.511]), así mismo fueron mayores a las de 72 horas postoperatorio (x̄ = 2.06; σ= 0.669; p <0.001; IC 95% [4.456- 5.127]); y la intensidad del dolor a las 24 horas postoperatorio fueron mayores que los resultados de 72 horas (p <0.001; IC 95% [2.390- 2.888]). Por lo tanto, se concluye que existe diferencias estadísticamente significativas entre las medidas de la intensidad del dolor de los pacientes postoperados en los tiempos de 12 horas, 24 horas y 72 horas con un tamaño de efecto grande F (1.765) = 685.252; p < 0.001; η2= 0.906; β -1 =1.
La Neurodidáctica como Innovación Metodológica del Conocimiento
Authors: Arellano Gualle Patricia del Carmen
Published: May 2023

El aula de clase se diversifica desde la composición cognitiva y la personalidad de cada alumno, en función, de la concepción de identidad epistémica del docente; esta realidad hologógica, genera un rizoma necesario de explorar mediante la noción sistémica; por cuanto, se atiende la multidireccionalidad pedagógica, en respuesta del imaginario escolar. Esta diadema, posibilita una implicación oportuna al estilo, ritmo y modo de aprender del sujeto en formación; requiriendo el educador, de nuevas formas de integrar o impactar en el subconsciente de sus estudiantes. Determinándose en la pragmasis del siglo XXI, una función neurodidáctica, a fin de identificar el nodo cognoscente, concatenándolo, con procesos singulares, significantes y con sentido integral en la composición del aprendizaje. Se requiere, por tanto, de una nueva visión, un nuevo gestor de la enseñanza, atrevido, sin temor de explorar la plasticidad de conciencia de las niñas y niños. De esta manera, se plantea, analizar documentalmente la neurodidáctica como innovación metodológica del conocimiento escolar en la educación básica general de Ecuador.
The Behavior of Bp He-strong Stars in the far UV—Paper I: HD 37776
Authors: Monier Richard
Published: May 2023

The analysis of thirty-two spectra of the Bp He-strong variable star HD 37776 recorded by the SWP camera on board the International Ultraviolet Explorer reveals variations of the far-ultraviolet spectral energy distribution over a time interval of about 26 hr. Variations are present shortwards of 1450 Å which can be partly attributed to variations of lines and continuum of Si ii. Other lines due to C ii, Si iii and Si iv also contribute to the opacity in this range too. The variations suggest that silicon and possibly carbon are not distributed in a uniform manner over the surface.
Severe Atypical Orbital Cellulitis in a Child With Chickenpox
Authors: Groppe Markus , Bottrill Ian D. , Norris Jonathan H.
Published: May 2023

A 2.5-year-old boy developed a right-sided eyelid swelling 3 days after onset of chickenpox. Orbital imaging confirmed an orbital cellulitis. The response to antibiotics was poor. The patient improved with intravenous steroids and an ischemic vasculitis secondary to chickenpox was postulated as the primary cause of the severe clinical picture.
[J Pediatr Ophthalmol Strabismus 2013;50:e49–e51.]
Existence and multiplicity of solutions for a Schrödinger type equations involving the fractional $ p(x) $-Laplacian
Authors: Zhu Shuhai
Published: May 2023

We are concerned with the following Schrödinger type equation with variable exponents

   \begin{document}$ \begin{equation*} (-\Delta_{p(x)})^{s}u+V(x)|u|^{p(x)-2}u = f(x, u)\, \, \, \, \text{in}\, \, \, \, \mathbb{R}^{N}, \end{equation*} $\end{document}

where $ (-\Delta_{p(x)})^{s} $ is the fractional $ p(x) $-Laplace operator, $ s\in (0, 1) $, $ V:\mathbb{R}^{N}\to (0, +\infty) $ is a continuous potential function, and $ f:\mathbb{R}^{N}\times\mathbb{R}\to \mathbb{R} $ satisfies the Carathéodory condition. We study the nonlinearity of this equation which is superlinear but does not satisfy the Ambrosetti-Rabinowitz type condition. By using variational techniques and the fountain theorem, we obtain the existence and multiplicity of nontrivial solutions. Furthermore, we show that the problem has a sequence of solutions with high energies.
Knowledge and attitudes toward COVID-19 vaccination in Sudan: A cross-sectional study
Authors: Badi Safaa , Babiker Loai Abdelgadir , Aldow Abdullah Yasseen , Abas Almigdad Badr Aldeen , Eisa Mazen Abdelhafiez , Abu-Ali Mohamed Nour , Abdella Wagass Abdelrhman , Marzouq Mohamed Elsir , Ahmed Musaab , Omer Abubakr Ali M , Ahmed Mohamed H
Published: May 2023

Background

Vaccines are an essential part of public health interventions to mitigate the devastating health and non-health impacts of COVID-19 pandemic. Despite the fact that Sudan launched the COVID-19 vaccination program in March 2021, only 10% of the population received their two primary doses of vaccines by the end of May 2022. This delayed uptake of vaccines obviously warrants investigation. Therefore, we have conducted this study to evaluate the knowledge, attitude and acceptance of the general population in Sudan toward COVID-19 vaccines.

Methodology

A descriptive cross-sectional community-based study. The data were collected using an electronic questionnaire from 403 individuals living in Khartoum, Sudan. The data were processed using the Statistical Package for Social Sciences (SPSS), and data analysis was performed using appropriate tests.

Results

51% of the participants were found to have sufficient knowledge about the COVID-19 vaccine, and the knowledge level is higher among those educated beyond the secondary school and those who were employed. Among those unvaccinated, only 47% of the participants expressed their intention to take the vaccine when offered to them. The major reason for not trusting the vaccine is safety concerns expressed by 65.5% of the unvaccinated.

Conclusion

Higher education levels and employment were associated with an increase in sufficient knowledge about the vaccine in around half of the participants. However, most of participants had not taken the vaccine at the time of the study, and the trust in vaccines is not high. Effective interventions by the health authorities are needed to address these issues in order to accelerate the COVID-19 vaccination program in Sudan.
Squid Game: The Hall of Screens in the Age of Platform Cosmopolitanism
Authors: Nan Mei Mingxue
Published: May 2023

The nine-episode Korean-language series Squid Game became a global sensation immediately upon its premiere on Netflix in September 2021. The show’s popularity and critical acclaim in the anglophone world had been unprecedented for a non-English series. This review provides a symptomatic reading of Squid Game’s global success and a short analysis of its visual appeal. It also explores the tension between Squid Game’s smooth and flat aesthetics that enables the show to travel and the culturally specific contexts it references. Some argue that the aesthetics lead to an ahistorical and superficial cultural understanding that overlooks the complexities of Korea’s history and US imperialism. Others argue that they challenge cultural hierarchies and democratize interactions. This reflects a broader challenge of balancing global accessibility with cultural specificity faced by East Asian serial dramas in the era of global streaming services. This review concludes by highlighting the role of platform cosmopolitanism in bridging cultural and linguistic barriers in meaningful ways.
Strategic Planning and Policy Framework for Implementation of Blockchain Technology in Education in India
Authors: Anjana  , Mukerji Siran
Published: May 2023

Blockchain technology is considered to be one of the most significant innovations in information technology of the 21st century. There is a wide spectrum of application of this technology in sectors including education. In view of the increasing popularity, greater acceptance, and merits of this technology, the Government in India has initiated steps towards adopting this technology. Blockchain technology as an important research area has the potential for its application in various domains (i.e., governance, banking and finance, education, cyber security, etc.). The objectives of this chapter are to showcase the strategic planning and policy framework for implementation of this technology in India and provide an insight into the international scenario and current status of implementation of blockchain technology across sectors in India. It deliberates upon the multidimensional use of blockchain and analyses the challenges in its implementation and the way ahead for this technology in education in India.
From Black to Green
Authors: Göçen Selin , Kurubacak Gülsün
Published: May 2023

Blockchain technology, which is one of the powerful tools that can be used in the development of education systems, is among the technologies that are abstained from for environmentally friendly activities due to its high level of energy consumption and gas emissions. However, there is not enough data that blockchain technology harms the environment or consumes more energy than other technologies. It is thought that this technology, which is more flexible than many technologies and will strengthen education systems, can be used in the design of environmentally friendly learning environments. Based on this idea, the authors drew a general framework about eco-friendly learning, green technologies, and blockchain in the chapter and presented suggestions for the design of environmentally friendly learning environments in the context of use cases of blockchain technology in education.
Get Ready for Blockchain Technology
Authors: Kundu Arnab
Published: May 2023

The fourth industrial revolution is peeping through blockchain technology since the invention of the steam engine, electricity, and information technology. It has come up with a lot of expectations and is now considered a ‘disruptive technology' stirring the fabric of society to its roots. This desk research concentrates on evaluating its potential for Indian schools. How could blockchain contribute to effective schooling in India? What could be the possible framework to implement this technology for progressive changes in schools? A thorough review of the existing literature and the Indian context reveals that blockchain is promising for Indian schools providing enhanced digital accuracy, openness, cost-saving operations, and a heightened constructivist learning paradigm. Based on these assumptions, the author has proposed a framework for blockchain implementation (FBI) in school operations which could be a substantial contribution to the ‘glocal' management of blockchain technology in schools.
Do You Feel It?
Authors: Villegas-Garza Anabel-Sofía , Medina-Quintero José Melchor , Alfaro-Pérez Jorge , Abrego Demian
Published: May 2023

Technology and interconnectivity make it possible to buy worldwide. More competition is in the market, and the client must find other ways to choose a product besides their utility, and that is where the experience takes place. Therefore, this study aims to explore the role of the five human senses in consumer shopping intention by their satisfaction. Grounded in the consumer culture theory (CCT) and the stimulus organism response (SOR) model, the authors propose a model to explain the relationship between the human senses and shopping intention. The study used a sample of 313 store clients in Northeastern Mexico. A questionnaire was utilized for the recollection of the data, and the testing of the hypotheses, structural equation modeling (SEM). Research supports four of the five hypotheses, suggesting that taste, sight, hearing, and touch, through satisfaction, conduct a shopping intention. On the other hand, the smell did not correlate with consumer satisfaction.
The Luxury Stores of the Future
Authors: Diogo Leonor
Published: May 2023

The growing investment and interest of leading brands in the applicability of digital transformation strategies seeks to respond to the high expectations of a consumer profile that is progressively more informed and consequently more detailed. Consumers, as we know them today, demand effective monitoring in their relationship with brands, adapted to each profile, increasingly based on a digital universe. The level of connectivity registered by customers demonstrates the adoption of an always-on behavior in line with the lifestyle and pace of life of the majority. This chapter intends to explore the impact and influence of technology on the consumer experience in physical stores of brands in the luxury sector, as well as identify technological and digital trends that contribute to a more interesting and successful relationship between consumers and the staff that accompanies them.
The Growth of Cyberbullying at Workplace After COVID-19
Authors: Marcos Blanca Martínez
Published: May 2023

Internal communication in organizations is one of the fundamental pillars for their correct development. Forms of communication were very scarce until the incorporation of ICTs in the labor market, but the rise of remote work has meant a new opening towards new forms of communication although also the emergence of new risks and problems that can have a very negative impact and that, as of today, have not been eradicated. Communication between the company's interest groups can have many benefits and translate into a large competitive advantage, but these new communication channels have also turned into a new tool through which new forms of harassment can be carried out (cyberbullying). In Spain, as all around the world, there are more and more cases of cyberbullying and very little existing legislation, leading to it becoming a serious problem that still has not been given sufficient visibility.
A Bibliometric Analysis of Higher Education and the Sustainable Development Goals
Authors: Aydogmus Hacer Yumurtaci , Turkan Yusuf Sait , Aydogmus Ufuk
Published: May 2023

Universities are institutions where scientific activities and research are carried out, innovations and inventions are developed, and people are educated. In this context, higher education (HE) is of great importance in achieving the sustainable development goals (SDGs) defined by the United Nations (UN) in 2015. Activities such as awareness activities on sustainability in university education; inclusion of sustainable development themes, such as inequality, fairness, inclusion, and diversity in course content; and social activities related to sustainability, help raise people who are much more sensitive and motivated about SDGs. The critical role of HE on SDGs has made studies in this area more important. The aim of this bibliometric review is to document the volume, growth, and geographical distribution of the literature on this subject, to identify important publications, to analyze the intellectual structure of this knowledge base and to identify emerging research trends.
Green Areas to Introduce Sustainability and Social Responsibility
Authors: Perdigones Alicia , Mazarrón Fernando R. , García José Luis
Published: May 2023

Green areas are emerging as a vehicle for change towards more sustainable cities. Green areas include, among other facilities, parks, gardens, and urban gardens. These facilities should be designed in an inclusive and integrating way, allowing their use by anyone. Their incorporation into urban policies has many advantages: a more naturalized landscape, improving the microclimate of urban neighborhoods, biodiversity, and the health, both physical and mental, of users and neighbors. They can also serve as an instrument for the education of citizens in environmental topics, healthy eating, and ethical and social awareness, from a very early age to the elderly.
Multinomial Regression Analysis on the Effect of Education on Consumers' Organic Product Purchase Preference
Authors: Tokal Pınar
Published: May 2023

The global organic food industry is a continuously expanding sector. Consumer preferences drive market development. Consumers who are concerned about issues such as healthy nutrition and reliable food supply have a positive attitude towards organic products. In this study, for 2135 consumers, the relationship between education and different demographic factors in organic product purchase preference was evaluated with the help of multinomial logistic regression analysis. It was determined that being a female consumer, being between the ages of 31-40, being a university and postgraduate graduate, being married, and having a household income above 30,001 TL were effective in the preference of organic product criteria. Regarding education, the likelihood of choosing the organic product standard over promotion was 1.02 times greater in the university graduate category and 2.23 times higher in the post-graduate category, compared to those who only completed primary school.
Effect of Minor Fe, Si Contents on Microstructure and Property of 7085 Alloy during Fabrication Processes
Authors: Chen Li Fang , Wen Kai , Li Xi Wu , Gao Guan Jun , Wang Zheng An , Xiong Bai Qing
Published: May 2023

Fe and Si elements can form non-dissolvable phases in Al-Zn-Mg-Cu alloys and furtherly affect the property of finished products while the influence of minor contents lacks sufficient investigations. In present work, 7085 alloy with different Fe and Si contents (named by LFS alloy, MFS alloy and HFS alloy as Fe and Si contents progressively enhanced) was investigated and corresponding microstructure and property during the whole fabrication were analyzed via OM, SEM and DSC observation and tensile property, fracture toughness and salty-spray corrosion property. The results showed that Fe-containing phase existed in as-cast microstructure of three alloys while part of Fe-containing phases of HFS alloy has Si element. After homogenization treatment, coarse eutectic phases had dissolved into the matrix while Fe-containing phase remained in the alloys. Similarly, Si element existed in some Fe-containing phases of HFS alloy. The order of area fraction of remaining Fe-containing phases for the three alloys was LFS alloy<MFS alloy<HFS alloy. After extrusion, Mg(Zn,Cu,Al)2 phase and Fe-containing phase possessed the majority, the former one was eliminated by solution treatment while the latter one had no obvious change. Under an unified aging treatment, the strength, elongation and fracture toughness were degraded with the increase of Fe and Si contents. Besides, the salt-spray corrosion property of HFS alloy was significantly inferior to LFS alloy and MFS alloy. This gave rise to a reference for controlling Fe and Si impurity of 7085 alloy for considering overall performance.
Subcellular Translocation of Yorkie through the PRP4K–CRM1 Axis Regulates Antimicrobial Peptides Transcription and Defense against Bacterial Infection in Crab
Authors: Qin Yukai , Zhao Ke , Zhou Kaimin , Luo Zhi , Nan Xingyu , Wang Qun , Li Weiwei
Published: May 2023

The Hippo signaling pathway plays important roles in innate immunity. In the current study, we found that bacterial infection did not influence mRNA and protein levels of yorkie (Yki), which is an important terminal molecule of the Hippo signaling pathway. However, bacterial infection promoted the translocation of Yki from the nucleus to the cytoplasm in Chinese mitten crab (Eriocheir sinensis), thus attenuating Yki-suppressed transcription of antimicrobial peptides through Cactus. Chromosome region maintenance 1 (CRM1)–silenced crab hemocytes significantly suppressed Yki translocation from the nucleus to the cytoplasm upon bacterial infection, resulting in significantly increased expression of Cactus, decreased expression of antimicrobial peptides, and higher bacterial susceptibility, which demonstrated the regulatory role of CRM1 in subcellular localization of Yki. However, RNA interference of Scalloped (Sd) exhibited no effect on the subcellular localization of Yki and its regulation of Cactus/antimicrobial peptides. Moreover, we elucidated that both CRM1 and Sd could interact with Yki and that the PRP4K-mediated phosphorylation of a conserved serine amino acid residue in the nuclear export signal of Yki is essential for interaction between Yki and CRM1; however, the phosphorylation did not affect the binding of Yki with Sd. We also found that bacterial infection significantly promoted the expression of PRP4K in hemocytes; RNA interference of PRP4K and phosphatase inhibitor suppressed Yki translocation from the nucleus to the cytoplasm, promoting Cactus expression and inhibiting antimicrobial peptide expression. Thus, subcellular localization of Yki regulates antibacterial infection through both PRP4K and CRM1 in crabs.
METTL3-Mediated m6A Modification of TRIF and MyD88 mRNAs Suppresses Innate Immunity in Teleost Fish, Miichthys miiuy
Authors: Geng Shang , Zheng Weiwei , Zhao Yan , Xu Tianjun
Published: May 2023

Methyltransferase (METTL3), the most important N6-methyladenosine (m6A) writer, plays a vital role in regulating immune-related signaling pathways. However, the underlying mechanism of METTL3 action remains largely unknown, especially in lower vertebrates. The results of this study show that METTL3 inhibits innate immune response and promotes the infection of miiuy croaker, Miichthys miiuy, by Siniperca chuatsi rhabdovirus and Vibrio anguillarum. Significantly, the function of METTL3 in inhibiting immunity depends on its methylase activity. Mechanistically, METTL3 increases the methylation level of trif and myd88 mRNA, rendering them sensitive to degradation by the YTHDF2/3 reader proteins. By contrast, we found that the YTHDF1 reader protein promotes the translation of myd88 mRNA. In summary, these results indicate that METTL3-mediated m6A modification of trif and myd88 mRNAs suppresses innate immunity by inhibiting the TLR pathway, unveiling a molecular mechanism by which RNA methylation controls innate immunity to pathogens in the teleost fish.
RETRACTION: Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus
Authors: Mignini Fiorenzo , Sabbatini Maurizio , D'Andrea Vito , Cavallotti Carlo
Published: May 2023

On behalf of the coauthors and with much regret, I must retract our publication entitled “Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus” published in European Journal of Histochemistry 2010;54(2):e17 for the following reason:
Unfortunately, now, after thirteen years, we have realized that some microphotographs published in the paper have been processed to improve the presentation of the images. The three surviving authors of the paper agree that the processing of the presentation images is against the COPE Ethical Editorial Standard, although the presentation images do not alter the integrity of methodological procedures and the results of the research work, obtained from the direct analysis of slides under microscope and rigorous statistical analysis of data; therefore, we, the authors of the above indicated paper, request the retraction of the publication.
We apologize for what happened.
 
Maurizio SabbatiniDip. di Scienze e Innovazione Tecnologica (DISIT)Università del Piemonte OrientaleAlessandria, Italy
Association between nutritional status and cognitive decline in non-institutionalized elderly patients evaluated in a geriatric outpatient setting
Authors: Pagliuca Raffaele , Cacciatore Stefano , Papa Mario Virgilio , Boccalone Eugenio , Pagliuca Mena Ilaria , Papa Federica Virginia , Gambardella Antonio
Published: May 2023

This study aims to assess the relationship between nutritional status and cognitive decline in a population of non-institutionalized elderly patients evaluated in a geriatric outpatient setting. Data from 144 patients admitted to the general geriatric outpatient services of Luigi Vanvitelli University Hospital (Naples, Italy) and San Felice a Cancello Hospital (San Felice a Cancello, Italy) were collected between January 1 and December 31, 2017. Cognitive function was evaluated through the mini-mental state examination and nutritional status was assessed through mini nutritional assessment. Logistic regression was used to assess the association between clinical characteristics and nutritional status, and it is reported as unadjusted, adjusted for age and sex, and adjusted for other potential confounding factors. In the unadjusted model, poor nutritional status was associated with a worse cognitive deficit (odds ratio (OR)=2.36; 95% confidence interval (CI)=1.77-3.55). The association remained significant after adjusting for age and sex (OR=2.36; 95% CI=1.77-3.55) and in the fully adjusted model (OR=2.92; 95% CI=1.90-5.64). In patients with dementia, malnutrition represents a significant burden that grows heavier as the disease progresses.
Results of an observational retrospective multicenter study: “Campania INternal medicine - the Clinical INternist for heart failure”
Authors: Gallucci Fernando , Marrone Emiliana , Nappi Roberto , Renis Maurizio , Coppola Maria Gabriella , Ciarambino Tiziana , D’Ambrosio Daniele , Maffettone Ada , D’Avino Maria , For HF Group Researchers CIN CIN
Published: May 2023

Introduction. The Campania population is characterized by a high incidence and prevalence of heart failure (HF). The aim of this study is to describe the clinical epidemiology, comorbidities, and treatments in HF patients admitted to Internal Medicine Wards (IMW) in Campania. Materials and Methods. It is a retrospective, regional, multicentric, observational study including patients admitted to 15 IMW in Campania, with an HF diagnosis, over a period of three consecutive months. Results. We identified 427 patients, stratified by ejection fraction (EF) category (127 EF≤40%; 216 EF 41-49%; 84 EF≥50%). In comparison with HFpEF subjects, patients with HFrEF were younger (74 years vs. 9 years), more commonly male (67% vs. 32%), and more likely to have an ischaemic aetiology (45% vs. 25%). The most used drugs at the time of hospitalization and after were Diuretics (80.3/93.5%), BBs (69.6/92.6%), and Statins (52.1/63.7%), with statistically significant pre-/post- differences (P≤0.05). Conclusions. EF is more likely to be non-preserved in younger males and in patients with CAD etiology. Hospitalization influences in a statistically significant way the change or adjustment of therapy for almost all drugs.
Prof. Innocenzo Caruso
Authors: Editors The
Published: May 2023

On July 29, 2022, Prof. Innocenzo Caruso, one of the first and best-known Italian rheumatologists, died at the age of 91 years.
Morphoeic Basal Cell Carcinoma – An Unusual Tumor Variant at an Unusual Site
Authors: Chandrakala C , Tharini G K
Published: May 2023

Basal cell carcinomas (BCC) are malignant neoplasm arising from the basal layer of epidermis, seen almost exclusively on hair-bearing areas of skin. There are many clinical and histopathological variants in BCC. The tumor commonly seen at the site of excessive sun exposure. It is a locally invasive tumor with rare metastasis. The most common site for the development of morphoeic BCC is over the face. Clinically, morphoeic BCC presents as morphea such as sclerotic plaque and histopathologically as densely hyalinized stroma with angulated strands of neoplastic basaloid cells. Ulceration of the lesion is uncommon in this type. We report a case of morphoeic BCC, an unusual tumor variant occurring over the back.
COVID-19 Vaccination in India
Authors: Chathra Namitha , Somaiah Savitha
Published: May 2023

Since the advent of COVID-19 vaccines, dermatologists have frequently come across patients, especially those receiving immunomodulatory drugs, who express concerns about the safety and efficacy of vaccines. In this review, we aim to provide guidelines to dermatologists with regard to the three COVID-19 vaccines licensed for use in India. All dermatology patients, even the ones on immunomodulatory drugs, need to be encouraged to take the vaccine. COVID-19 vaccines are not contraindicated in individuals afflicted with eczema; atopic dermatitis; psoriasis; vitiligo; lichen planus; urticaria; connective tissue disorders; and bacterial, mycobacterial, viral, or fungal infections. However, those who have been seriously ill requiring hospitalization are advised to wait for 4–8 weeks. For patients on immunomodulatory drugs, when the disease is stable, the drug may be withheld or dosage reduced for 1–2 weeks following vaccination. However, the vaccination may be given without any modification in the drug/biological. People with a history of anaphylaxis/urticaria can receive a COVID-19 vaccine with 30 min postvaccination observation period. Absolute contraindications include a history of immediate hypersensitivity to any component of the vaccination and hypersensitivity following first dose of vaccination. Patients who have received vaccination can undergo procedures such as skin biopsy, cautery, cryotherapy, lasers, chemical peels, excisions, biopsy, and hair transplantation; fillers may be scheduled 2 weeks before or after the vaccination.
Giant Subcutaneous Granuloma Annulare
Authors: Harish M R , Shashikumar BM , Magod Priyanka R , Gowda Deepadarshan K
Published: May 2023

Subcutaneous granuloma annulare is an uncommon, benign self-limiting cutaneous disease, almost exclusively seen in young children. We report a case of 31-year-old male patient, presented with asymptomatic firm plaques over the left lateral malleoli and dorsum of the feet. Histopathological examination was done to confirm the diagnosis and the lesions responded well to monthly doses of the combination of rifampicin, ofloxacin, minocycline (ROM) therapy and intralesional steroid therapy. This case is reported for its unusual presentation of very large plaque in an adult male and its resolution after combined ROM and intralesional steroid therapy.
A Female with Mucocutaneous Telangiectases and Portal Hypertension
Authors: Chandibhamar Vidhi S , Patel Bhagirath R , Patel Ani , Padhiyar Jignaben K
Published: May 2023

Osler-Weber-Rendu syndrome, also known as hereditary hemorrhagic telangiectasia, is a rare autosomal dominant disorder manifested by telangiectases of the skin and mucous membranes and arteriovenous malformations of various organ systems. We report a case of 45-year-old postmenopausal woman who presented to dermatology department for evaluation of compressible vascular lesion involving bilateral palms and oral cavity for the past 3 months' duration. On further evaluation, she was found to have portal hypertension and multiple cavernoma formation on place of portal vein.
Alkaptonuria
Authors: Gupta Mudita , Sharma Rajni , Rani Ritu
Published: May 2023

Alkaptonuria (AKU) is a multisystemic autosomal recessive disease due to deficiency of enzyme homogentisate dioxygenase leading to accumulation of homogentisic acid. Urine becoming dark on oxygenation or alkalinization is the first symptom but is often ignored. The patient usually presents with pigment deposition in connective tissue and cartilage after the third decade. This pigment deposition not only alters the aesthetics but also leads to alteration in the activity of different tissues due to inflammation and subsequent fibrosis or calcification. We are presenting an adult male who was asymptomatic till 5 years back when he started having backache for which he was taking analgesics off and was diagnosed to be having AKU at the age of 58 years.
Pleomorphic Xanthomas
Authors: Singh Shivangi , Tiwary Pankaj Kumar , Singh Anupama
Published: May 2023

Xanthomas are the subcutaneous lipid deposits which can be seen in normolipedemic or hyperlipidemic conditions. Xanathomas are usually of single type and presence of polymorphic xanthomas arise suspicion of dyslipidemia. We report a case of young girl presenting with pleomorphic xanthomas (Xanthelasma palpebrarum, intertriginous Xanthomas, tendon Xanthomas, and eruptive xanthomas), hypothyroidism and multiple cardiac valvular involvements with very high serum total cholesterol and low-density lipoprotein along with deranged lipid profile in both parents. Pleomorphic xanthoma arouses a suspicion and helped in making a diagnosis of rare homozygous familial hypercholesterolemia.
Blueberry Look-Alike Masson's Hemangioma over the Thigh
Authors: Rai Yashaswi , Savitha AS , Nagesh TS , Prasannan Swathy , Manjunath Sneha , Reddy Tarun Deepak
Published: May 2023

Masson's hemangioma (MH), also known as intravascular papillary endothelial hyperplasia, is a rare benign vascular tumor. Histopathology helps to confirm the diagnosis, wherein a papillary proliferation of thin-walled capillaries is almost always associated with thrombus formation in the lumen of a vessel. We report the case of a 48-year-old female with a purple-colored swelling over the right thigh that was diagnosed as MH with the help of histopathological examination. Dermoscopy was also done, and the findings were reported.
A Descriptive Case-Control Study on Assessment of Iron Profile in Patients with and Without Melasma
Authors: Prakash Megha , Manjunath Namrata C , Deepali BS
Published: May 2023

Background:

Melasma or chloasma is a common acquired hyper melanosis, characterized by dark, irregular hyperpigmented macules and patches over the malar areas, lips, nose and forehead. Iron overload manifests with skin hyperpigmentation. Therefore, it is important to understand the role of iron in patients with melasma.

Objectives:

(1) To assess serum iron profile in non-pregnant women and men with melasma. (2) To assess the same parameters in age and sex matched controls.

Materials and Methods:

A descriptive case–control study with 35 cases of melasma and 35 age and sex-matched controls was conducted between December 2019 and March 2020, to assess the association between melasma and iron deficiency.

Results:

Among 35 cases of melasma, 85.7% were females, the most common type was the malar type 68.8%, sunlight was the most-common risk factor and 100% had deranged iron profile. Mean ferritin levels in the melasma group was 15.204 ng/ml while in control group it was 71.717 ng/ml. Mean serum iron levels in melasma group was 28.585 μg/dl while in that of controls were 135.018 μg/dl. Other iron parameters also showed significant iron deficiency in melasma patients.

Conclusion:

Well-known factors implicated in the etiology of melasma include sunlight, Oral contraceptive pills with oestrogen, pregnancy and smoking. This study indicates that iron deficiency is also an important etiological factor and hence treatment of iron deficiency may be a novel therapeutic approach in patients with refractory melasma.
Giant Venous Malformation of the Tongue with Macroglossia
Authors: Sharma Reena Kumari , Makharia Archita , Gupta Mudita , Thakur Suresh
Published: May 2023

Venous malformations (VMs) are congenital slow flow vascular malformations that are usually present at birth. They grow proportionate with the age and do not regress with time differentiating them from hemangiomas. VM presents as bluish discoloration of skin/mucosa or as soft subcutaneous masses. It may affect any organ, including viscera-like gastrointestinal tract or brain. VM is generally slowly progressive and asymptomatic as they grow slowly with age. We report the case of asymptomatic giant VM over the tongue for which the patient presented due to herpetic stomatitis.
A Case Study Comparing Active vs. Passive Enablers for Vehicle Interior Noise Reduction
Authors: Tousignant Todd , Kim Geon-Seok , Trumpy David , Walt Adam , Wickman Matthew , McCain Dan , Magnuson Levi
Published: May 2023

The implementation of enablers on a luxury sport utility vehicle is used to illustrate the development process for reduction of road noise. The vehicle in this case study was launched into production with two tuned mass dampers for reduction of low frequency road noise content which was amplified by frame modes. Additionally, resonators were integrated into the wheels (rims) to address the dominant cavity resonance frequencies. The results of this successful production implementation are illustrated herein.

An RNC (road noise cancellation) system was integrated into the case vehicle to assess its performance relative to the passive enablers listed above. This production representative (embedded software solution) RNC system utilized the vehicle’s existing audio system for creation of active noise to cancel noise content which was predicted using accelerometers mounted to the vehicle chassis.

A comparison of in-vehicle noise indicated a significant reduction at low frequencies (at all seating locations) when utilizing the active noise control solution. These noise improvements are coupled with a vehicle mass reduction of greater than 4 kg, when compared to the passive enabler solution.