bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyzing the Impact of Decreasing Out-of-Vehicle Time of Public Transportation Travel on Accessibility to Tertiary Hospitals
Authors: Wang Zhenbao , Liu Dong , Li Shihao , Liu Shuyue , Li Huiqing , Chen Ning
Published: August 2023

Unequal distribution of healthcare resources can lead to many fundamental problems, including the accessibility and equity of care in different regions. Existing studies often focus on administrative divisions, street zones, and conducting analyses of healthcare accessibility, but there is a lack of research on healthcare accessibility analysis specifically targeting apartment complexes. Furthermore, there is insufficient consideration of the impact of out-of-vehicle time on healthcare accessibility through public transportation. Taking Beijing’s 5th Ring Road area as an example, we used multiple data sources to construct a framework for the accessibility of medical care in apartment complexes using public transportation. We assumed two scenarios of 1/2 and 1/3 reduction in out-of-vehicle time. We compared and analyzed the changes in accessibility and equity under the two scenarios to investigate the impact of out-of-vehicle time on accessibility and equity of medical care in apartment complexes. The results show that (1) reducing out-of-vehicle time does not guarantee increased accessibility to all apartment complexes. (2) Under both scenarios, the accessibility of most apartment complexes within the fourth and fifth rings increased, and the accessibility of most apartment complexes within the Daxing District increased; otherwise, the accessibility of most apartment complexes in other areas decreased, and the decrease in accessibility was more significant for the scenario with a 1/2 reduction in out-of-vehicle time than for the scenario with a 1/3 reduction in out-of-vehicle time. (3) In both scenarios, the Gini coefficients of residential accessibility were calculated separately for inter-ring and administrative divisions, and the equity of residential accessibility increased in each division; the equity of accessibility increased more with a 1/2 out-of-vehicle time reduction than with a 1/3 out-of-vehicle time reduction. The framework proposed in this paper allows us to analyze the impact of out-of-vehicle time of public transportation on accessibility to medical care for apartment complexes.
Digital Competence Development in Public Administration Higher Education
Authors: Budai Balázs Benjámin , Csuhai Sándor , Tózsa István
Published: August 2023

Today, citizens’ digital readiness and competence are competitive factors. While users with a high level of digital competence are usually associated with intensive and conscious use by consumers, those with a lower level of competence are characterized by passive consumer use and lagging in technology. It is essential to continuously develop and monitor competence levels because digital skills, the way digital tools are used, and the effects of use are interlinked. The importance of digital competence is also evident in public administration because its presence affects the quality of public services, which has an impact on the entire population. In this social aspect, digital competence is extremely important for public administration employees. In our study, we aim to investigate the input competence level of undergraduate (BA) students in public administration, and the output competence level reached after one semester in targeted training. We analyze the values in several dimensions and draw conclusions. When measuring digital competence, we relied on the EU reference material, the Citizen Digital Competence Framework, based on digital competence areas and proficiency levels such as information and data literacy, communication and collaboration, digital content creation, safety, and problem solving. The DigCompSat self-assessment questionnaire was used for the survey. The result of the study was an order of magnitude difference between the self-assessment and the real level of competence of the students. It can be useful for respondents to realize where they have gaps in their knowledge and competence. This is what is referred to as a ’change in attitude‘ in our study. There are factors related to gender, age, and prior training that influence the potential shifts between the segments. It was also found that the above factors applied differently in each range of competence. Concerning implementation of this research, it can be assumed that the larger amplitude movements may not necessarily be knowledge or skills, but rather ’changes in attitude’. Its practical importance might lie in the possibility to orient students.
Mechanical Properties and Strength Characteristics of Rock–Coal–Rock Assemblages under Different Peripheral Pressures
Authors: Wang Hongda , Chang Jucai , Wang Tuo , Zhang Hualei , Guo Yijun
Published: August 2023

To investigate the deformation and damage characteristics of internal coal bodies of small pillars under different pressures, rock–coal–rock assemblage samples were subjected to the conventional triaxial compression test to analyze the mechanical behavior characteristics under different pressures. The results showed that, with the increase in peripheral pressure, the peak strength and modulus of elasticity of the assemblage specimens increased, the range of fracture compaction stage gradually decreased, and the specimen was gradually transformed from brittle to ductile. With an increase in peripheral pressure, the residual strength gradually increased, and the strength decay coefficient gradually decreased. The strength decay coefficient decreased the most at 0–10 MPa, and this decrease slowed down after exceeding 15 MPa. When the peripheral pressure was 0 MPa, the damage degree of the coal pillar was larger. With the increase in peripheral pressure, the number of cracks in the coal column increased, the damage degree increased more, and mixed damage characteristics of tension–shear were found. Based on the Hoek–Brown criterion, the strength criterion applicable to the specimen of rock–coal–rock combination was obtained through numerical fitting iteration, which provides an experimental and theoretical basis for realizing the stability control of small coal columns.
Quantum Big Bounce of the Isotropic Universe Using Relational Time
Authors: Giovannetti Eleonora , Maione Fabio , Montani Giovanni
Published: August 2023

We analyze the canonical quantum dynamics of the isotropic Universe with a metric approach by adopting a self-interacting scalar field as relational time. When the potential term is absent, we are able to associate the expanding and collapsing dynamics of the Universe with the positive- and negative-frequency modes that emerge in the Wheeler–DeWitt equation. On the other side, when the potential term is present, a non-zero transition amplitude from positive- to negative-frequency states arises, as in standard relativistic scattering theory below the particle creation threshold. In particular, we are able to compute the transition probability for an expanding Universe that emerges from a collapsing regime both in the standard quantization procedure and in the polymer formulation. The probability distribution results similar in the two cases, and its maximum takes place when the mean values of the momentum essentially coincide in the in-going and out-going wave packets, as it would take place in a semiclassical Big Bounce dynamics.
Age and Growth of Hedinichthys yarkandensis (Day, 1877) in the Hotan River
Authors: Wang Xin-Yue , Chen Sheng-Ao , Song Yong , Wang Cheng-Xin , Liu Fei
Published: August 2023

Hedinichthys yarkandensis (Day, 1877) has been highlighted in research and evaluated as a class II key protected aquatic wildlife in Xinjiang Uygur Autonomous Region. To enhance the study of fish resources in the Hotan River, further germplasm conservation of fishery resources specific to the Tarim River Basin should be carried out, and the development of the aquatic seed industry should be promoted. A total of 1275 H. yarkandensis individuals were collected from 2020–2021. Fish ecological methods were used to explore the population ecological characteristics and ecological habits of H. yarkandensis. We found that the age of H. yarkandensis ranged from one to seven based on lapillus otoliths, and two-plus individuals accounted for more. The age structure composition reveals stable genetic performance and good population fecundity. The fitting correlations of standard length and body weight reveal that H. yarkandensis in the Hotan River is a uniformly growing fish. The ratio of females to males is 0.87:1. The Fulton condition index of males was slightly higher than that of females due to individual miniaturization. The comparative study found that the growth parameters of the Hotan River population (L∞ = 302.772, W∞ = 310.8450, t0 = −0.4608) were higher than those of the other groups. The feeding demand of H. yarkandensis in the Hotan River was guaranteed because the effect of human activities was small in the watershed area and the watershed ecosystem was more stable, which resulted in stable germplasm resources in the Hotan River population.
Surface Water–Groundwater Transformation Patterns in the Jianghan Plain after the Impoundment of the Three Gorges Project and the Opening of the Yangtze-to-Hanjiang Water Transfer Project
Authors: Feng Jinping , Shao Dongguo , Gu Wenquan , Liu Luguang , Dong Wei , Miao Donghao
Published: August 2023

Understanding the law of surface water–groundwater conversion in the face of high-intensity human activities is still a challenge. In this study, we employed statistical and system dynamics methods to investigate the surface water–groundwater conversion law in the Jianghan Plain following the impoundment of the Three Gorges Project (TGP) and the Yangtze-to-Hanjiang Water Transfer Project (YHWTP). The groundwater level’s long data set was used for the first time to study the water level change and water exchange in the research region after the impoundment of the TGP and the delivery of water from the YHWTP. The findings suggest a significant decrease in the interannual trend of the surface water level and groundwater level in the research region. It was observed that a 1m rise in the surface water level can lead to a 0.11–0.38 m rise in the groundwater level. The water level fluctuation coefficients of the surface water level and groundwater level are influenced by the impoundment of the TGP and the water delivery from the YHWTP, causing them to increase and decrease, respectively. In general, the surface water recharges the groundwater in the studied region. The water exchanges between the surface water and groundwater in the Yangtze River’s main stream, the middle region of the Hanjiang Plain, and the lower reaches of the Hanjiang River are, on average, 10−2 m3/(d·m), 10−5 m3/(d·m), and 10−3 m3/(d·m) orders of magnitude, respectively. The water exchange in the Yangtze River’s main stream was reduced after TGP impoundment, and it was enhanced following YHWTP water delivery.
A Study on the Characteristics of Beach Profile Evolution According to the Particle Size Variation of Beach Nourishment
Authors: Shim Kyu-Tae , Kim Kyu-Han
Published: August 2023

This study investigated the beach nourishment effect and topographical changes when using nourishment sand with relatively large particle diameters to perform beach nourishment on a beach subject to erosion. A physical model test was conducted in a 2D wave flume with an installed wind tunnel. The experiment examined the sediment transport mechanism under conditions with wind and waves. Although applying nourishment sand with large particle diameters attenuated sediment transport, the increase in particle diameter was not always proportional to the reduction in topographical changes. Increasing the particle diameter of the nourishment sand increased the friction force between particles, resulting in large-scale erosion and accretion around the coastline, and this trend increased with winds. Also, with wind, the wave run-up height increased, the undertow became stronger, and large-scale scouring occurred at the boundary between the nourishment sand and the existing beach. Increasing the particle diameter of the nourishment sand played a role in reducing the run-up phenomenon (d50: 1.0 mm with 24–50%, d50: 5.0 mm with 59–83%), and the range of particles moved by winds also decreased (d50: 1.0 mm with 10–38%, d50: 5.0 mm with 5–37%).
Determination of Bisphenol A (BPA) in the Port of Gdynia Waters Using Gas Chromatography Coupled with Mass Spectrometry (GC-MS)
Authors: Bojke Aleksandra , Littwin Małgorzata , Szpiech Agata , Duljas Ewelina , Jasiński Paweł , Wittstock Izabela , Jażdżewska Olga , Galer-Tatarowicz Katarzyna
Published: August 2023

This paper presents a procedure for the determination of bisphenol A (BPA) in seawater. Gas chromatography coupled with mass spectrometry (GC-MS) was used as the analytical method, preceded by analyte isolation via solid-phase extraction (SPE). Initially, the best conditions for extraction, derivatization, and GC-MS analysis were established. The need for derivatization in the determination of BPA was investigated, and for this reason, two methods of sample preparation were compared: with and without the derivatization step. The parameters of the two methods of sample preparation were compared with each other, and a more efficient method was chosen for the analysis of marine water samples. Afterwards, the validation process was carried out and the following parameters were determined: limit of detection (LOD), limit of quantification (LOQ), linearity, precision, reproducibility, and repeatability. Finally, the results of the determination of bisphenol A in water samples collected from five harbor basins of the Port of Gdynia using an unmanned mobile research unit, HydroDron-1, were presented. The identified concentrations ranged from 0.01 µg/L to 0.03 µg/L, depending on the investigated area.
COMPARATIVE ANALYSIS OF THE OLDEST INDOOR MARKETS IN ROSTOV-ON-DON
Authors: Petrusenko Yu.
Published: August 2023

This paper examines the historical emergence of the oldest markets: the Nakhichevan Covered Market on the Market Square (1914) and the Covered Market on the Old Bazaar (1893), reveals their architectural, artistic and design features. Reconstruction, restoration and preservation of objects in modern urban conditions are investigated, new factual data are obtained. The purpose of the study is to review and compare the covered markets of Rostov-on-Don and Nakhichevan-on-Don. Each object was analyzed from the point of view of its location in the structure of the urban fabric, functional and planning solutions, design features, as well as architectural and artistic features, historical and cultural value preserved to the present day. As a result of the conducted research, it was revealed that both objects have similar historically established locations and market formations in the emerging urban structure, similar functional planning and design solutions. Architectural solutions have similar compositional features of building facades and volumetric solutions, but there are characteristic architectural and artistic features for each pavilion. In modern conditions, the objects have been preserved in good condition, but have lost their original appearance of the «brick style». Both buildings were originally made by the method of open masonry of red brick without the use of plaster and paint. As a result of comparative analysis, it was revealed that the Indoor Market in the Old Bazaar (1893) served as an analogue for the Nakhichevan indoor market on the Market Square.
Ahmet Muhip Dıranas'ın "Çıkmaz" Adlı Tiyatro Oyununda Yapı ve İzlek
Authors: EYAN Bilginç
Published: August 2023

Ahmet Muhip Dıranas, edebiyat dünyamıza katmış olduğu şiirler ile ismini duyurmuş olan güçlü Cumhuriyet Dönemi sanatçılarındandır. Ahmet Muhip Dıranas, yazın yaşamındaki tanınmışlığını daha çok şiirleri ve şairlik yönüyle sağlamış olsa da birbirine yakın dönemlerde Gölgeler ve Çıkmaz adlı iki tiyatro oyunu da yazarak sanat alanını genişletmiştir. Bu çalışmanın ana malzemesi ve temel konusu olan Çıkmaz adlı tiyatro oyunu, 1947 yılında kaleme alınmış olan ve aynı dönemlerde çeşitli tiyatro salonlarında sahnelenerek beğeni kazanan önemli yapıtlardandır. Toplumsal olarak belirli rol ve değerleri temsilen oyuna yerleştirilmiş birçok renkli karakterin etrafında dönen ve olayların, kişileri “çıkmaz”a sürüklediği bir kurguya sahip olan bu tiyatro oyununda Ahmet Muhip Dıranas’ın, topluma dönük bakış açısı, eleştiri alanları ve hedeflediği insan biçimi başta olmak üzere birçok unsur, belirli imge ve aktarımlarla görünür kılınmıştır. Bu çalışmada Çıkmaz adlı tiyatro oyunu; kişiler dünyası, olay, mekân, zaman ve bakış açısı ile anlatıcı çerçevesinde yapısal açılardan analiz edilmiş ve oyunda yazar tarafından ortaya konulmuş olan temalar doğrultusunda izleksel olarak değerlendirilmiştir.
Соціокультурні процеси трансформації сучасної музичної освіти України
Authors: Лошков Юрій
Published: August 2023

Метою статті є висвітлення соціокультурних трансформаційних процесів у сучасній музичній освіті України. Визначено, що ідейною основою професійного музичного мистецтва європейського типу є розуміння музики як засобу морального виховання, на підставі осмислення формування музичної освіти в Україні. Доведено, що система навчальних та соціокультурних закладів, призваних забезпечувати функціонування музичної культури в сучасній Україні, склалася на основі естетики академічного музичного мистецтва. Виявлені трансформаційні процеси в галузі музичної освіти України, зумовлені соціокультурними зрушеннями. Отже, трансформації в галузі музичної освіти України зумовлені соціокультурними процесами як викликами ідейному фундаменту академічного музичного мистецтва. Соціальні зрушення спричиняють різнорівневі трансформації, які сучасниками неможливо оцінити адекватно. Так, культивування нових музичних спеціалізацій можна розглядати, з одного боку, як шлях академізації певних неакадемічних напрямів; з іншого, як початок деакадемізації музичної освіти. Питання, поставлені щодо невідповідності змісту академічної музичної освіти реаліям сучасної репрезентативної практики, свідчать про необхідність модернізації змістовних складових з метою підвищення конкурентоздатності випускника - професійного музиканта освітньої системи. Трансформації системного рівня також не можна сприймати однозначно. В цьому контексті вбачається можливим свідомо впливати та регулювати трансформаційні процеси за умови формулювання владою виваженої довгострокової культурної політики, а отже й розуміння місця та ролі музичного мистецтва в українському суспільстві.
Towards modeling of phonation and its recovery in unilateral vocal fold paralysis by fluid-structure interaction
Authors: Naseri MohammadAmin , Razavi Seyed Esmail
Published: August 2023

Introduction: Vocal folds are responsible for sound generation. In unilateral vocal fold paralysis (UVFP), the recurrent laryngeal nerve, which controls the vocal folds, is paralyzed. Medialization laryngoplasty is a surgery in which an implant is inserted to push the paralyzed vocal fold to the centerline to recover phonation. Methods: Here, a numerical simulation is used to calculate flow-related parameters to give insight into what happens in healthy and treated(implanted) vocal folds and their enhancement. In the present work, airflow over vocal folds is modeled considering fluid-structure interaction (FSI) and varying inlet pressure. The governing equations are discretized for fluid and solid domains and solved using the Galerkin finite element method. The boundary conditions for healthy and unilaterally paralyzed vocal folds were imposed to agree with real cases behavior. Results: The results showed the effectiveness of medialization laryngoplasty in treating unilateral vocal fold paralysis concerning healthy vocal folds. Conclusion: This simulation provided a better insight into treatment results for patient-specific cases.
Optimized cutaneous delivery of anti-wrinkle dipeptide KT via molecular modification: Preformulation, permeation, and the importance of conjugate chain length
Authors: Sayed Tabatabaei Mahsa , Kobarfard Farzad , Aboofazeli Reza , Ramezanpour Sorour , Moghimi Hamid Reza
Published: August 2023

Introduction: Anti-aging peptides, such as dipeptide KT, are promising rejuvenating agents and have recently received significant attention. However, their hydrophilic nature makes skin absorption therapeutically inadequate. The excessive hydrophilicity of peptides is partially solved by lipoidal conjugates, however, the increased molecular weight due to conjugation creates a new obstacle to skin permeation. Methods: In an attempt to concurrently solve these limitations, here we have studied different short-mid chain fatty acids (C6-C18) conjugates of dipeptide KT. Different fatty acid chain lengths of C6, C8, C10, C12, C14, C16, and C18 were considered to be conjugated with KT and screened in-silico. Of those, C8, C10, and C12 were preferred and synthesized alongside two controls of the parent drug (KT) and C16 (Pal-KT) as the commercialized form to be studied mechanistically. Subsequently, they were structurally characterized and underwent preformulation, supramolecular investigations (e.g., thermal behavior, solubility, surface-acting, crystalline structure), and skin absorption studies. Results: Data showed that the synthesized conjugates substantially outperformed Pal-KT in terms of molecular weight, lipophilicity, melting point, and aqueous solubility. In addition, unlike KT, they all demonstrated amphiphilicity-related features. The maximum and minimum skin permeation were assigned to C8-KT (33.2%) and KT (0.004%). Moreover, permeability coefficients (Kp) of the C8-KT, C10-KT, C12-KT, and C16-KT were calculated to be about 22000, 3800, 3400, and 1600 times higher than KT, respectively. Conclusion: Conjugating lower molecular weight fatty acids and optimizing lipophilicity can enhance molecular properties, skin absorption, and the ability to form supramolecular structures. This, in turn, leads to the development of superior anti-wrinkle products and formulations.
Cytotoxicity of WT1-reactive T cells against Wilms tumor: An implication for antigen-specific adoptive immunotherapy
Authors: Monzavi Seyed Mostafa , Hamidieh Amir Ali , Vasei Mohammad , Ai Jafar , Ahmadbeigi Naser , Arshadi Hamid , Muhammadnejad Samad , Kajbafzadeh Abdol-Mohammad
Published: August 2023

Introduction: T cells that recognize WT1 peptides have been shown to efficiently eliminate WT1-expressing tumor cells. This study was designed to investigate the feasibility of isolating WT1-reactive T cells from peripheral blood mononuclear cells (PBMCs) from healthy donors and patients with Wilms tumor, and to assess the cytotoxicity mediated by these cells against Wilms tumor cells (WiTu cells). Methods: WT1-reactive T cells were enriched and isolated by stimulating PBMCs with a WT1 peptide pool and interferon-γ capture-based immunomagnetic separation (IMS). Using the lactate dehydrogenase release assay, the in vitro cytotoxicity of the isolated cells and standard chemotherapy was evaluated on WiTu cells. Results: Higher proportions of WT1-reactive T cells were isolated from patients with Wilms tumor compared to those isolated from HDs. WT1-reactive T cells produced > 50% specific lysis when co-cultured with WT1+ WiTu cells at the highest effector-to-target (E:T) ratio in this study (i.e., 5:1), compared to <23% when co-cultured with WT1- WiTu cells at the same ratio. WT1-reactive T cells showed anti-tumoral activity in a dose-dependent manner and mediated significantly greater cytotoxicity than the non-WT1-reactive fraction of PBMCs on WT1+ WiTu cells. The cytotoxicity of standard chemotherapy was significantly lower than that of WT1-reactive T cells when co-cultured with WT1+ WiTu cells at E:T ratios of 2:1 and 5:1. Conclusion: WT1-reactive T cells can be effectively enriched from the PBMCs of patients with Wilms tumor. Ex vivo generated WT1-reactive T cells might be considered an adoptive immunotherapeutic option for WT1+ Wilms tumors.
Comparison the therapeutic effects of bone marrow CD144+ endothelial cells and CD146+ mesenchymal stem cells in POF rats
Authors: Nazdikbin Yamchi Nahideh , Amjadi Farhad , Beheshti Rahim , Hassanpour Mehdi , Shirazi Reza , Tamadon Amin , Rahbarghazi Reza , Mahdipour Mahdi
Published: August 2023

Introduction: Premature ovarian insufficiency (POI) is a challenging issue in terms of reproduction biology. In this study, therapeutic properties of bone marrow CD146+ mesenchymal stem cells (MSCs) and CD144+ endothelial cells (ECs) were separately investigated in rats with POI. Methods: POI rats were classified into control POI, POI + CD146+ MSCs, and POI + CD144+ ECs groups. Enriched CD146+ MSCs and CD144+ ECs were directly injected into ovarian tissue (15 × 104 cells/10 μL) in relevant groups. After 4 weeks, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels were measured in blood samples. Ovarian tissues were collected and subjected to Hematoxylin-Eosin and Masson’s trichrome staining. The expression of angp-2, vegfr-2, smad-2, -4, -6, and tgf-β1 was studied using qRT-PCR analysis. Histopathological examination indicated an increased pattern of atretic follicles in the POI group related to the control rats (P<0.0001). Results: Data indicated that injection of POI + CD146+ MSCs and CD144+ ECs in POI rats reduced atretic follicles and increased the number of normal follicles (P<0.01). Along with these changes, the content of blue-colored collagen fibers was diminished after cell transplantation. Besides, cell transplantation in POI rats had the potential to reduce increased FSH, and LH levels (P<0.05). In contrast, E2 content was increased in POI + CD146+ MSCs and POI + CD144+ ECs groups compared to control POI rats, indicating restoration of follicular function. CD144+ (smad-2, and -4) and CD146+ (smad-6) cells altered the activity of genes belonging TGF-β signaling pathway. Unlike POI + CD146+ MSCs, aberrant angiogenesis properties were significantly down-regulated in POI + CD144+ ECs related to the control POI group (P<0.05). Conclusion: The transplantation of bone marrow CD146+ and CD144+ cells can lead to the restoration of ovarian tissue function in POI rats via modulating different mechanisms associated with angiogenesis and fibrosis
Cardioprotective effects of simvastatin‑loaded nano‑niosomes on cardiomyocytes in cardiac ischemia
Authors: Aboutaleb Nahid , Mehrab Mohseni Mahdieh , Naseroleslami Maryam
Published: August 2023

Background. Cardiac ischemia is the major cause of morbidity and mortality which can be increased by Statins. This study aimed to increase the effectiveness of simvastatin in the form of niosomes. Methods. In this study, 25 male Wistar rats were divided into 5 groups: control, ischemia (induced by closed LAD), ischemia receiving nano-niosomes, ischemia receiving simvastatin, and ischemia receiving simvastatin-loaded nano-niosomes. One month after the drug injection, RNA was extracted from the heart tissue of the studied groups, cDNA was synthesized, and a real-time PCR test was performed using specific primers. SPSS 21.0 software was used for statistical analysis. Analysis of variance was used to investigate the effect of the interventions, and Tukey's post hoc test was used to investigate a significant difference (P<0.05) between the control groups and other groups as well as between intervention groups. Results. Apoptosis and autophagy increased significantly in the ischemia group compared to the control group (P<0.05). In the simvastatin-loaded nano-niosomes group, compared to the simvastatin group, apoptosis and autophagy showed a significant decrease (P<0.05), and also in both simvastatin-loaded nano-niosomes and simvastatin group, compared to the control group, apoptosis and autophagy showed a significant decrease. (P<0.05). Conclusion. Simvastatin is an effective drug in the recovery of cardiac ischemia, but the main problem in using simvastatin is its instability and degradability, and the use of its niosomes form solves this problem properly. Practical Implications. Simvastatin‑loaded nano‑niosomes is more effective in reducing heart ischemia damage compared to simvastatin.
Perturbational Effects of Lithium Cation on Phenytoin Tautomers
Authors: Türker Lemi
Published: August 2023

Phenytoin is a long-standing, anti-seizure drug used in the treatment of epilepsy, however it has been classified as possibly carcinogenic to humans. It may exhibit 1,3- and 1,5-type proton tautomerism. In the present study, within the constraints of density functional theory at the level of B3LYP/6-31++G(d,p), tautomerism of phenytoin has been investigated. The obtained data collected for vacuum as well as aqueous conditions indicated that the equilibrium concentration of the enol type tautomer should be low. On the other hand, lithium is often referred as an antimaniac drug and used clinically to prevent mood swings in patients with bipolar effective disorder. The present study also considers the mutual interaction of lithium cation and phenytoin at the molecular level. Both the unperturbed and perturbed (by lithium cation) phenytoin tautomers have exothermic heat of formation values and favorable Gibbs free energy of formation values. They are electronically stable. Various quantum chemical data for the unperturbed and perturbed tautomers of phenytoin have been collected and discussed.
ОСОБЛИВОСТІ ВИДАЛЕННЯ РЕТЕНОВАНИХ ТА НАПІВРЕТЕНОВАНИХ ТРЕТІХ ВЕЛИКИХ КУТНІХ ЗУБІВ
Authors: Мар’ян-Йовбак В.Ю. , Йовбак С.В.
Published: August 2023

Метою даної статті є аналіз та узагальнення даних сучасної наукової літератури щодо особливостей видалення ретенованих та напівретенованих третіх великих кутніх зубів. Результати. Ретенованими називаються зуби, які розташовані в кістковій тканині щелепи і не прорізалися, що є досить поширеною аномалією. Напівретеновані зуби – це зуби, які частково прорізалися. Хірургічне видалення третіх великих кутніх зубів верхньої та нижньої зубної дуги є однією з найпоширеніших операцій, в тому числі профілактичне видалення безсимптомних ретенованих третіх молярів, оскільки завдяки цьому можна запобігти розвитку таких патологій, як карієс і резорбція коренів сусідніх зубів, перикороніту, гінгівіту, пародонтозу, розвитку кіст або пухлин, а також усунути причину «скупченості» зубного ряду. Операція видалення ретенованого та напівретенованого зуба найчастіше супроводжується післяопераційним болем, набряком і обмеженням відкривання рота. Менш поширеними ускладненнями є альвеолярний остит, пошкодження гілок трійчастого нера, перелом кута нижньої щелепи, абсцес, флегмона, одонтогенний синусит, післяопераційна кровотеча, зміщення уламків зуба, нориця, підшкірна емфізема, пневмомедіастинум, пневморагія та ін. Треті моляри нижньої щелепи розташовані близько до нижньощелепного каналу, який містить нижній комірковий нерв, артерію та вену. Цей тісний зв’язок створює ризик пошкодження нижнього коміркового нерва під час видалення третього моляра нижньої щелепи. По завершенні операції пацієнтові може бути запропоновано застосування фібрину, збагаченого тромбоцитами з власної плазми пацієнта, що сприяє швидкому загоєнню рани і зменшенню післяопераційного набряку. Висновок. Отже, видалення ретенованого та напівретенованого третього великого кутнього зуба є багатоетапним втручанням, яке потребує адекватної діагностики та підготовки для запобігання виникнення ускладнень. Особливістю видалення є те, що, дотримуючись загальприйнятих принципів ходу втручання, підхід до операції є індивідуальним і залежить від положення осі ретенованого зуба в щелепі та відносно осі сусідніх зубів, стану коміркового відростка щелепи, віку пацієнтів та їхнього загальносоматичного статусу.
КЛІНІКО-ЛАБОРАТОРНА ОЦІНКА ВІДДАЛЕНИХ РЕЗУЛЬТАТІВ ЛІКУВАННЯ ХРОНІЧНОГО ГЕНЕРАЛІЗОВАНОГО ПАРОДОНТИТУ У ОСІБ, ЩО ПАЛЯТЬ ЕЛЕКТРОННІ СИГАРЕТИ
Authors: Кіюн І.Д. , Кузняк Н.Б.
Published: August 2023

Мета дослідження. Клініко-лабораторна оцінка віддалених результатів лікування хронічного генералізованого пародонтиту, у осіб, що використовують електронні прилади для тютюнопаління. Методи дослідження. Клініколабораторні дослідження були проведені у 70 осіб віком 18–44 рр. з діагнозом «хронічний генералізований пародонтит початкового-І ступеня», що палять електронні сигарети. Для оцінки віддалених результатів лікування (через 6 і 12 місяців) сформували дві групи. Проводили визначення активності уреази та лізоциму у ротовій рідині та ступеня дисбіозу порожнини рота. Наукова новизна. У результаті застосування запропонованої нами методики, яка включала двохетапну місцеву комплексну терапію та підтримувальну терапію через 12 місяців у 81,36±4,60% осіб основної групи діагностували «стабілізацію» стану тканин пародонту, проти 16,26±7,27% осіб контрольної групи, у яких проводилося традиційне лікування генералізованого пародонтиту початкового – І ступеня, p<0,01. Також вдалося здійснити суттєвий вплив на покращення біохімічних маркерів ротової рідини, а саме уреази та лізоциму стосовно даних до лікування. Висновки. Таким чином, розроблена методика комплексного лікування початкових форм хронічного генерілазованого пародонтиту в осіб молодого віку, що використовують електронні засоби тютюнопаління, включала цілеспрямовану патогенетичну терапію, яка забезпечувала високі клінічні результати та нормалізацію біохімічних маркерів запалення ротової рідини у віддалені терміни спостереження.
ПОРІВНЯЛЬНА ХАРАКТЕРИСТИКА СТАНУ ТВЕРДИХ ТКАНИН ЗУБІВ ПІСЛЯ ВИБІЛЮВАННЯ І ЗАСТОСУВАННЯ ЛІКУВАЛЬНО- ПРОФІЛАКТИЧНОГО КОМПЛЕКСУ
Authors: Пахлеванзаде В.А.
Published: August 2023

Мета дослідження. Розробка лікувального комплексу, сприяючого зниженню больової чутливості зубів після вибілювання і що чинить мінералізуючу дію, а також вивчення його клінічної ефективності. Матеріали і методи дослідження. Всього в дослідженнях взяли участь 20 людина у віці від 18 до 27 років, яким проводили вибілювання зубів. Для вибілювання застосовували відбілюючий гель на основі перекису карбаміду з вмістом фтору: гель Opalescence PF 35% Regular. Результати дослідження. З 20 осіб, яким проводили вибілювання зубів, у 18 (90%) з них з'явилася гіперчутливість зубів.Холод, гарячіше, солодке, кисле викликало больову реакцію. При цьому більшість пацієнтів пред'являли скарги на холод (12 осіб, 60%) і кисле (7 осіб, 35%). Реакція на солодке була зафіксована у 1 людини (5%), а на кисле – у 3-х осіб (15%). Усім пацієнтам із скаргами на підвищену чутливість зубів був запропонований лікувальний комплекс, спрямований на зниження гіперестезії. При призначенні лікувального комплексу виходили їх 2-х позицій: зниження чутливості зубів за рахунок призначення препаратів, сприяючих швидкої закупорки дентинних канальців, а також застосування засобів, стимулюючих салівацію з метою збільшення змісту в слині кальцію і фосфатів, що беруть участь в ремінералізації зубів. Лікування трьохетапне. На першому етапі (2–3 дні) призначалися десенсітайзери для зниження інтенсивності гострого болю, зокрема, Saturol D (виробник Україна). На другому етапі були призначені: ремінералізуюча зубна паста ApaCare®, яка містить медичний гідроксиапатит, який виконуючи функцію рідкої емалі ремінералізує і відновлює тверді тканини зуба щодня. На 3-му етапі на зуби наносили лак, що містить фтор. Дослідження показали, що після застосування лікувального комплексу показники чутливості знизилися по відношенню до початкового рівня на 81% і 90%, збільшилося кількість осіб з високою кислотостійкістю емалі (61%); кількість осіб з мінімальними показниками салівації зменшилося майже в 3 рази.
The Use of Integral Citation in English Students’ Final Project Reports
Authors: Nugraha Danny , Khorina Mulyati , Agoes Farida , Sulyaningsih Iis
Published: August 2023

This paper is concerned with integral citation employed by English students of Politeknik Negeri Bandung in their Final Project Reports (FPR). Thus, the aims of this study were to investigate the most integral citation type used by the students in their FPR. In conducting the study, 18 FPR focusing on analysis produced in 2022 were collected as data source. Applying qualitative method and text analysis, the results reveal several things. First, the students favor integral citation than non-integral citation. Second, verb controlling appears more than naming. In verb controlling citation, lexical verb state is commonly used compared with other lexical verbs.  Whereas in naming, the phrase according to + the cited authors is the mostly used. this study has implication in improving the students’ academic skills, especially in doing citation.
Clinical phenomenology of anxiety disorders in patients with hypothyroidism
Authors: Nevzorova S.I.
Published: August 2023

Recently, there has been a significant increase in thyroid pathology worldwide. In most studies of thyroid pathology, it is increasingly common to see an increase in thyroid hypofunction among individuals from different population groups. The aim of the study is to investigate the clinical and psychopathological features of the formation and course of anxiety disorders in patients with primary hypothyroidism. It was examined 74 patients of both sexes, aged 30–55 years with primary hypothyroidism (mild – 26.1% of patients, moderate – 45.2%, severe – 28.7%) who were diagnosed with anxiety disorder of organic nature (F06.4). The following examination methods were used in the study: clinical-neurological, clinical-psychopathological, anamnestic, psychodiagnostic. The most common complaints among the examined patients were constant feelings of anxiety, unmotivated anxiety, mood depression, various fears and intrusive memories, loss of interest in previous activities, general weakness, and rapid physical and intellectual fatigue. According to the study results, clinical picture of anxiety disorders in the examined patients is represented by anxious (38.2% of the examined), panic (36.7%) and anxious-depressive (25.1%) variants of psychopathological symptoms. The analysis of the severity of anxiety manifestations using the State-Trait Anxiety Inventory shows that in hypothyroidism there was an increase in the level of situational and personal anxiety. Analysis of neuropsychiatric stress level in the examined patients showed predominance of extensive (excessive) stress in moderate and severe hypothyroidism and intense (moderate) stress in patients with mild hypothyroidism. The data obtained during study allow to develop diagnostic criteria for anxiety disorders in patients with organic and symptomatic mental illnesses due to primary hypothyroidism.

Keywords: thyroid gland, neurotic disorders, anxiety, worry.
Responsible changes in the brick industry: clay bricks and PET blocks
Authors: DIAZ-VEGA María Eugenia , ZAMORA-CASTRO Sergio Aurelio , GRAJEDA-ROSADO Ruth María
Published: August 2023

The peripherals illegal settlements in Puebla, have common denominator to born in a situation of urban vulnerability, it means with a lack of infrastructure and basic services and on some occasions on land not suitable for urbanization. This is the case of the Cuitláhuac neighborhood where approximately 400 inhabitants live. The neighborhood only has electricity service, his high urban vulnerability becomes worst in the rainy season with the formation of gullies, flooding sites and soil erosion, affecting the mobility of the inhabitants. Authorities ignore these problems and not always included them in urban development plans. The objective of research is to look for environmental alternatives to reduce urban vulnerability in illegal settlements. The methodology is based on action research and the main techniques were: documentary review, physical and virtual field trips, virtual meetings and semi-directed interviews. A relevant conclusion is that green infrastructure is feasible and can be implemented in the short term and that it arouses much collaborative interest from the inhabitants both for its implementation and for its maintenance.
Fractal transformations of recursive walks in the Julia fern
Authors: RAMOS-ESCAMILLA María
Published: August 2023

One of the most studied fractals corresponds to the Julia Set and one of its elements can be obtained with the following recursive formula in the complex plane: Zi+1 = Zi2 - 1, the result depends on the chosen starting complex number. We can define the Julia set of a complex variable polynomial as the boundary of the set of points that escape to infinity when iterating this polynomial. This means that the orbit of an element of the Julia set does not escape infinity.
Analysis of the participation of the faculty in the PRODEP evaluation of a DES
Authors: TORRES-BUGDUD Arturo , PALOMARES-RUIZ María Blanca Elizabeth , SORDIA-SALINAS Cesar , BÁEZ-VILLARREAL Esteban
Published: August 2023

Quality is a fundamental issue that occupies educational institutions at all levels, not only nationally but also internationally, teachers, as well as education administrators, assume a leading role with society every day, seeking to achieve the desirable profile. For its performance, this work exposes the experience of the evaluation of teachers that is applied in Mexico, called PRODEP desirable profile in a Higher Education unit, with the support of the historical-logical method and the hypothetical-deductive method, the present document was carried out. when observing a decrease in its historical indicators, whose trend in annual participations was on the rise, being the reason for the present work its analysis and discussion.
Towards the development of functional technological units in the academic area of computing and electronics
Authors: POZAS-CÁRDENAS Mariano Javier , HERNÁNDEZ-SÁNCHEZ David , CURIEL-ANAYA Arturo , TORRES-SAMPERIO Gonzalo Alberto
Published: August 2023

The objective of this project is to show the feasibility of systematizing some of the administrative activities of the electronics laboratory and computer classrooms in the Academic Area of Computing and Electronics (AACyE), where its main activity is teaching and research, to move towards more functional work units with the use of technology, which we will call Functional Technological Units. In the present work the conditions in which the technological work units are stagnant due to not having adequate information management are described in an introductory manner. The methodologies used for the development of this research were based on the Organizational Development model and the use of agile methodologies such as XP, ERP or WSDM. As a result, two developments of web-oriented systems validated by the ISO 9126 standard and making a qualitative weighting based on the Likert scale are shown. As for the discussion, it focuses on collaborative work and the creation of a synergy between students, teachers and administrative staff. The results that were obtained have allowed administrative processes to be carried out with greater efficiency, impacting on the teaching, administrative work and the training of students in the AACyE.
ULTRASOUND-ASSISTED EXTRACTION SENYAWA ANTIOKSIDAN DARI LIMBAH BIJI PEMBUATAN MINYAK BUAH MERAH (Pandanus conoideus)
Authors: Wehantouw Frenly , Situngkir Risma , Suoth Elly
Published: August 2023

The aim of this research was to obtain antioxidant active component from Papuan red fruit oil waste using  Ultrasound-assisted extraction. The research was done started from the making of Papuan red fruit oil, extraction and bioactive component analysis (total tocopherol and betacaroten) using spectrophotometry. The result shows that waste from Papuan red fruit oil process contains high amount of yield at 20 minutes extraction time with total carotenoid 20, 23 ppm and tocopherol absorbance 1.04. Ultrasound assisted extraction method significantly increase carotenoid content aw well as tocopherol (p<0.05).
Kadar Flavonoid Total Ekstrak Etanol Daun Jarak Pagar (Jatropha curcas L) Dengan Metode Spektrofotometri UV-Visibe
Authors: Nova Ramadhan Krisdiyanto  , Muhammad Saad
Published: August 2023

Terdapat beberapa aktifitas biologis dalam daun jarak pagar antara lain sebagai

antidiabetes dan antihipertensi. Flavonoid adalah senyawa metabolit sekunder yang

bertanggung jawab terhadap aktifitas tersebut. Penelitian ini bertujuan untuk

menghitung kandungan total flavonoid ekstrak daun jarak pagar, serta

mengidentifikasi kandungan alkaloid, terpenoid, saponin, flavonoid, dan tanin yang

terdapat pada ekstrak daun jarak pagar. Uji skrining fitokimia pada penelitian ini

dilakukan dengan penambahan reagen dan dilakukan pengamatan terhadap perubahan

warna yang terjadi. Penetapan kadar dilakukan dengan metode spektrofotometri UVVis menggunakan reagen AlCl3, dengan baku pembanding yaitu quersetin. Identifikasi

senyawa ekstrak daun jarak pagar pada penelitian ini mendapatkan hasil positif

saponin, terpenoid, flavonoid, tanin, dan alkaloid. Konsentrasi flavonoid total ekstrak

didapatkan sebesar 1,649706 mgQE/g, dengan %KV 0,021909%. Daun jarak pagar

dapat menjadi alternatif sumber flavanoid, sebagai bahan obat alami.
Diseño metódico de un tren de transmisión para un arreglo extremidad-rueda
Authors: Ontiveros Rocha Luis Enrique , Soriano Peña Juan Felipe , Valencia Garay Luis Alberto , Pacheco Ibarra J. Jesús , Rodríguez Gutiérrez Jesús Eduardo
Published: August 2023

Este estudio se enfoca en el diseño de un subsistema de transmisión de potencia que será usado en la propulsión de un robot móvil con extremidades y ruedas; debe permitir al sistema robótico un desplazamiento en superficies estructuradas, y accidentadas, consumir la menor energía posible, y contar con un sistema de transmisión compacto y ligero. Para ello se presenta un modelo del comportamiento del arreglo de transmisión interactuando con el sistema robot donde se utilizarán como base del sistema engranajes armónicos, que tienen como principales características altas relaciones de transmisión en configuraciones espaciales relativamente pequeñas. Se emplea una metodología de diseño con un marco de referencia lógico de siete etapas, cuyo resultado es un concepto del sistema de transmisión que satisface los requerimientos específicos de operación.
Multiyear changes in oceanographic factors of the autumn migration of the Black Sea anchovy to the shores of Crimea from satellite data in 2000–2021
Authors: Panov B. N. , Smirnov S. S. , Spiridonova E. O.
Published: August 2023

The purpose of this work is to analyze long-term changes in oceanographic indicators in the southeastern area of the northwestern Black Sea in November-December 2000–2021, which determine the migration activity and fishery performance of the Black Sea hammerhead off the coast of Crimea.

   Materials and methods used: The fishery statistics, data of information system Copernicus Marine Service of satellite altimetry and surface temperature of waters near the western coast of the Crimean Peninsula in November-December 2000–2021, graphic and statistical methods of the analysis of these data were used in work.

   Novelty: The element of novelty in the work is the use of oceanographic satellite data in the study of the behaviour of the Black Sea anchovy and long-term changes in its catch off the coast of Crimea.

   Result: During the period under consideration, the tendency of catch increase of the Black Sea anchovy of the Crimean coast is obvious. The main reasons for the activation of the autumn migration of the Black Sea anchovy to the shores of Crimea is a multi-year increase in sea surface temperature and the strengthening of south-eastern currents to the west of the Crimean Peninsula.

   Practical significance: The revealed causes of the mass autumn approaches of the Black Sea anchovy to the Crimean coast allow hoping for possibilities of their use in forecasting the results of the Black Sea anchovy fishing in the  Crimean fishing area, and also give grounds for continuing research with special attention to monitoring of the Black Sea anchovy occurrence on the Crimean shelf.
In memory of Oleg Ivanovich Betin
Authors: Kolonchin K. V. , Glubokovsky M. K. , Pinchuk E. O. , Truba A. S. , Voloshin G. A. , Yanovskaya N. V.
Published: August 2023

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