bluuebunny/crossref_metadata_2025 huggingface dataset:
U–Pb zircon age dating of diamond-bearing gneiss from Fjørtoft reveals repeated burial of the Baltoscandian margin during the Caledonian Orogeny
Authors: Walczak Katarzyna , Cuthbert Simon , Kooijman Ellen , Majka Jarosław , Smit Matthijs A.
Published: May 2019

The first find of microdiamond in the Nordøyane ultra-high-pressure (UHP) domain of the Western Gneiss Region (WGR) of the Scandinavian Caledonides reshaped tectonic models for the region. Nevertheless, in spite of much progress regarding the meaning and significance of this find, the history of rock that the diamonds were found in is complex and still largely ambiguous. To investigate this, we report U–Pb zircon ages obtained from the exact crushed sample material in which metamorphic diamond was first found. The grains exhibit complicated internal zoning with distinct detrital cores overgrown by metamorphic rims. The cores yielded a range of ages from the Archaean to the late Neoproterozoic / early Cambrian. This detrital zircon age spectrum is broadly similar to detrital signatures recorded by metasedimentary rocks of the Lower and Middle allochthons elsewhere within the orogen. Thus, our dating results support the previously proposed affinity of the studied gneiss to the Seve–Blåhø Nappe of the Middle Allochthon. Metamorphic rims yielded a well-defined peak at 447 ± 2 Ma and a broad population that ranges between c. 437 and 423 Ma. The data reveal a prolonged metamorphic history of the Fjørtoft gneiss that is far more complex then would be expected for a UHP rock that has seen a single burial and exhumation cycle. The data are consistent with a model involving multiple such cycles, which would provide renewed support for the dunk tectonics model that has been postulated for the region.
Morphometric analysis of active normal faulting in slow-deformation areas : examples in the Lower Rhine Embayment
Authors: Camelbeeck T. , Martin H. , Vanneste K. , Verbeeck K. , Meghraoui M.
Published: May 2019

We studied the applicability of classical scarp degradation modelling to active normal faults in the Lower Rhine Embayment. Our quantitative analysis was conducted on the frontal Bree fault scarp (Feldbiss fault) in Belgium and the Peel fault scarp near the city of Neer in the Netherlands. Vertical offset and diffusion age of these scarps have been modelled from elevation profiles across the studied faults using the diffusion equation. For that purpose, a computer-program (profil 2000) has been written, providing a sensitivity analysis of the determined parameters in function of the spatial repartition of the elevation measurements along the considered profiles. The results of this morphometric analysis have been validated by a comparison with the geologic record of the tectonic activity observed in the trenches excavated at the sites where the measurements have been conducted.

We conclude that the modelling can only be applied to study tectonic activity since the Last Glacial Maximum (±14-19 kyr BP) because the surface expression of older paleoearthquakes in unconsolidated Late Pleistocene sediments has been erased by the strong erosive phase that occurred at the end of this glacial period. Even for Holocene scarps, morphologic dating seems very difficult because man-made perturbations destroyed surface evidence of the very recent fault activity in many sites. Nevertheless, we estimate that an appropriate value for the mass diffusivity constant for~ 1-m-high scarps in the investigated region is 0.002 to 0.010 m2/yr. On the other hand, vertical offsets can be determined with a good precision. These amount to respectively ~1 m and 1,3 m since the Last Glacial Maximum on the Feldbiss fault in Belgium and the Peel fault near Roermond in the Netherlands.
The Deposition History of the Coversands along the Bree Fault Escarpment, NE Belgium
Authors: Frechen M. , Vanneste K. , Verbeeck K. , Paulissen E. , Camelbeeck T.
Published: May 2019

The coversands along the Bree fault escarpment, NE Belgium, were investigated by a combined dating approach including infrared optically stimulated luminescence (IRSL), thermoluminescence (TL) and radiocarbon methods. Four trenches were excavated cutting the fault scarp near the village of Bree in northeast Belgium. Altogether 17 luminescence samples and seven radiocarbon samples were investigated in order to set up a more reliable and precise chronological frame for the local coversand stratigraphy and the timing of Late Quaternary earthquake events. The chronological results indicate at least five accumulation periods for the coversand units in the area of interest. The oldest coversands were deposited during Saalian or Early Weichselian followed by coversands deposited during the Early and/or Middle Weichselian. At least three coversand units can be distinguished for the time span of the Late Weichselian to Holocene. Significant TL age underestimation of more than 20% compared to IRSL was found for samples from Trench 4. Most of the IRSL age estimates are in agreement with radiocarbon dates from the same section.
Preliminary geologic, geomorphologic and geophysical studies for the paleoseismological analysis of the Amer fault (NE Spain)
Authors: Fleta J. , Santanach P. , Goula X. , Martínez P. , Grellet B. , Masana E.
Published: May 2019

The Amer fault is a 30 km long normal fault, which generated the damaging earthquakes of March and May 1427. Triangular facets, wine glass drainage basins, alluvial fans and scarps along the Amer fault mountain front provide evidence of its recent activity. Topographic profiling, electrical logging, tomographic and high-resolution seismic profiling along the northern segment of the Amer fault showed the following: i) no evidence of surface deformation in recent deposits; ii) fault scarps produced by the Amer fault located only on old alluvial fans, probably Pleistocene in age, and iii) Amer fault related deformation reaching upper Quaternary levels, but not the uppermost horizons. The high sedimentation rate (nearly one order of magnitude greater than the fault slip rate) due to the filling of the lake, which resulted from the damming of the Fluvià river by the Bosc de Tosca lava flow (17,000 yr BP), can account for the absence of surface deformation on Holocene sediments.
Seismic hazard analysis results for the Lower Rhine Graben and the importance of paleoseismic data
Authors: Atakan K. , Ojeda A. , Camelbeeck T. , Meghraoui M.
Published: May 2019

Seismic hazard in low seismicity areas of Europe has traditionally been considered insignificant. However, in the light of the recently conducted paleoseismic studies along the Rhine Graben, a revision is required. Previously applied standard probabilistic seismic hazard assessment (PSHA) methods, using Poissonian approach for the earthquake occurrence, can now be substituted by renewal models where fault parameters such as the maximum magnitude, recurrence interval and the elapsed time since the last occurrence of a large earthquake, can be utilized. In this study, the application and the influence of the available paleoseismic data in the Lower Rhine Graben to seismic hazard analysis is demonstrated. The resulting hazard maps, when compared to the standard PSHA using Poissonian approach, indicate a more precise geographical distribution of the estimated seismic hazard levels. The influence of the paleoseismic data seem to be less important for return periods less than a 1000 years. Among the different input models, the highest values reach to 170 cm/sec2for a 1000 year return period using a combination of Poissonian and renewal models.
VOLUNTARY STERILIZATION IN FLANDERS
Authors: LODEWIJCKX E.
Published: May 2019

From 1966 to 1990 there was a marked rise in the use of voluntary sterilization in Flanders, followed by a fall in women under the age of 40. In the last three decades a remarkable change has occurred in the choice between male and female sterilization. Compared with many other European countries, sterilization of men and women is widely practised in Flanders. In 1996 40% of 40- to 44-year-old women underwent voluntarily sterilization or had voluntarily sterilized partners. Additionally, another 9% of these women were sterilized for medical reasons. Voluntarily sterilized couples are on average older than non-sterilized couples, and, obviously, consider their families to be complete. For couples with a complete family, parity is the most important predictor in the choice between sterilization and non-sterilization. Regularly practising Catholics undergo sterilization least. Also, highly educated couples are less likely to have a sterilization. Couples who ever experienced a contraceptive failure choose sterilization more. Voluntary sterilization has no substantial effect on the fertility of the population since the effect on the prevented numbers of both wanted and unwanted births appears to be small. However, if voluntary sterilization did not occur, differences in fertility within the population would probably increase. It is presumed that the popularity of voluntary sterilization in Flanders has passed its peak and that its use will decline in the near future.
THE DURATION OF LACTATIONAL AMENORRHOEA IN URBAN BANGLADESHI WOMEN
Authors: RAHMAN MAHMUDUR , MASCIE-TAYLOR C. G. N. , ROSETTA L.
Published: May 2019

The duration of lactational amenorrhoea, and infant feeding patterns and behaviour, were investigated in a sample of 97 mother–infant pairs living in a poor urban area of Dhaka, Bangladesh. A seven-hour time allocation method was used to determine the number of breast-feeding bouts and their duration. The seven-hour observation period was conducted on five occasions: at birth, 1 month, 4 months, 8 months and either 10 or 11 months. The median duration of lactational amenorrhoea was determined to be 24·07 weeks using survival analysis. Mothers who breast-fed their babies for longer and more frequently had, on average, a longer period of lactational amenorrhoea. There was no relationship between sociodemographic characteristics of the mother and duration of lactational amenorrhoea, nor was there any significant relationship between maternal anthropometry and birth weight of the baby and duration of lactational amenorrhoea, but there was a tendency for women with lower body mass index to have longer durations. Using the Cox proportional hazards model, the best predictor of duration of lactational amenorrhoea was the mean of months 0 and 1 durations of breast-feeding, adjusted for the mean frequencies for those months. The introduction of weaning food was also an important predictor.
TIME ALLOCATION TO SUBSISTENCE ACTIVITIES AMONG THE HULI IN RURAL AND URBAN PAPUA NEW GUINEA
Authors: UMEZAKI MASAHIRO , YAMAUCHI TARO , OHTSUKA RYUTARO
Published: May 2019

Time spent on subsistence activities was compared between rural sedentes and urban migrants of the Huli population in Papua New Guinea. Person-day observation data were collected for rural sedentes (441) in the Tari basin and for urban migrants in Port Moresby (175). The time spent on subsistence activities by males was longer in the urban area than in rural areas, while that by females was similar in both areas. Conspicuous gender inequality with respect to labour hours in rural areas seems to diminish when people move to urban areas, reflecting the different subsistence regime between rural and urban environments.
“Brāhmaṇa” as an honorific in “Indianized” mainland Southeast Asia: a linguistic approach
Authors: Pain Frédéric
Published: May 2019

This article aims at demonstrating that the Old Khmerb/vraḥoriginates from a syllabic depletion of the Sanskrit wordbrāhmaṇathrough a monosyllabization process, a widespread diachronic phenomenon among the Mon-Khmer languages of Mainland Southeast Asia. The paper will also show that this term must have been originally used as an honorific for deities and, consequently, for royalty. It therefore respectfully disagrees with two other current hypotheses according to whichb/vraḥwould be an autochthonous Mon-Khmer word or would originate in the Sanskrit/Pali wordvara-“excellent, splendid, noble”. After being borrowed from Sanskrit, the Old Khmerbraḥspread via a contact phenomenon: from Old Khmer to Old Siamese, from Old Siamese to Old Shan through the “Thai Continuum”, and from Old Shan to Old Burmese. The implications of this paper are twofold: firstly, it will sketch out a pattern for the historical relationships between different peoples of Mainland Southeast Asia; then, it will propose a first phase of Indianization in Southeast Asia, namely a local reconnotation of Indo-Aryan terms according to autochthonous socio-political contingencies, and consequently bring a draft answer to the “Woltersian” question: what is the local connotation of Indo-Aryan terms?
Modified action as a determinant of adult and age-related sensorimotor integration: Where does it begin?
Authors: Dinse Hubert R.
Published: May 2019

Modified action, either artificially induced or occurring naturally during life-span, alters organization and processing of primary somatosensory cortex, thereby serving as a predictor of age-related changes. These findings, together with the interconnectedness between motor-sensory systems and temporally-distributed processing across hierarchical levels, throws into question a sharp division between early perception and cognition, and suggest that composite codes of perception and action might not be limited to higher areas.
Real action in a virtual world
Authors: Goodale Melvyn A.
Published: May 2019

O'Regan & Noë run into some difficulty in trying to reconcile their “seeing as acting” proposal with the perception and action account of the functions of the two streams of visual projections in the primate cerebral cortex. I suggest that part of the problem is their reluctance to acknowledge that the mechanisms in the ventral stream may play a more critical role in visual awareness and qualia than mechanisms in the dorsal stream.
TEC: Integrated view of perception and action or framework for response selection?
Authors: Proctor Robert W. , Vu Kim-Phuong L.
Published: May 2019

The Theory of Event Coding (TEC) presented in Hommel et al.'s target article provides a useful heuristic framework for stimulating research. Although the authors present TEC as providing a more integrated view of perception and action than classical information processing, TEC is restricted to the stage often called response selection and shares many features with existing theories.
Multi-level sensorimotor interactions
Authors: Vogt Stefan , Hecht Heiko
Published: May 2019

We share the authors' general approach to the study of perception and action, but rather than singling out a particular level of “late perceptual” and “early motor” processing for sensorimotor interactions, we argue that these can arise at multiple levels during action preparation and execution. Recent data on action-perception transfer are used to illustrate this perspective.
Still room for representations
Authors: Van Gulick Robert
Published: May 2019

One can support O'Regan & Noë's (O&N's) commitment to the active nature of vision and the importance of sensorimotor contingencies without joining them in rejecting any significant role for neurally realized visual representations in the process.
Proportion of Hospital Deaths Potentially Attributable to Nosocomial Infection
Authors: García-Martín Miguel , Lardelli-Claret Pablo , Jiménez-Moleón José Juan , Bueno-Cavanillas Aurora , Luna-del-Castillo Juan de Dios , Gálvez-Vargas Ramón
Published: May 2019

Objective:

To determine the fraction of hospital deaths potentially associated with nosocomial infection (NI).

Design:

A matched (1:1) case-control study.

Setting:

An 800-bed, tertiary-care, teaching hospital.

Patients:

All patients older than 14 years who were admitted to the hospital between January 1, 1990, and January 1, 1991, were eligible. All 524 consecutive deaths that occurred in the hospital comprised the case group. For each case, a control patient was matched for primary admission diagnosis and admission date.

Outcome Measures:

The proportion of hospital deaths potentially associated with NI was estimated from the population attributable risk (PAR) adjusted for age, gender, service, severity of illness, length of stay, and quality of the medical record.

Results:

For stays longer than 48 hours, the PAR for all NIs was estimated to be 21.3% (95% confidence interval [CI95], 16.8%-30.5%). The greatest proportion of deaths potentially associated with NIs was observed in patients with only one infection (PAR, 15.0%; CI96, 10.9%-22.6%) and bacteremia or sepsis (PAR, 7.7%;CI95,4.6%-11.6%).

Conclusions:

NIs are associated with a large proportion of intrahospital deaths. This information may help clinicians and healthcare managers to assess the impact of programs for the prevention and control of NIs on intrahospital death.
Effect of different diet supplements in the pre- and post-partum period on reproductive performance in the dairy cow
Authors: Gardner N. H. , Reynolds C. K. , Phipps R.H. , Jones A.K. , Beever D.E.
Published: May 2019

The study compared the impact of feeding different energy supplements (barley, molassed sugar beet and fat) prior to calving and the effects of feeding supplemental fat post-partum, on subsequent production and reproductive efficiency of dairy cows. Forty-eight multiparous Holstein-Friesian dairy cows were assigned to one of two groups, six weeks prior to expected calving date and fed a grass based total mixed ration according to ME requirements for late gestation. Group 1 was supplemented with barley (B) or molassed sugar beet feed (SB) prior to calving and was then given a high starch lactation ration. Group 2 was supplemented with either fat (F) or no supplement (C) pre partum, and was then given a similar lactation ration as Group 1 but supplemented with fat. Lactation rations were fed through to week-20 post partum and the cows were monitored during this period. Milk yield (P<0.002) and milkfat (P<0.02) production were higher and milk protein concentration (P<0.001) was lower in Group 2. The number of days to first rise in progesterone following parturition was greater (P<0.01) in Group 2. Due to the design of the study, effects of prepartum supplementation were only evaluated within each lactation ration group. Conception rate to first service was higher (P<0.001) for B than SB supplemented cows in Group 1 and higher (P<0.02) for F than C supplemented cows in Group 2. Services per conception were lower (P=0.06) for B than SB supplemented cows in Group 1 and lower (P<0.05) for F than C supplemented cows in Group 2. Overall pregnancy rates and days open were not significantly different between the groups. The data shows that pre-partum nutrition had an important role in determining subsequent fertility. Despite having negative effects early post partum, supplementing with fat did not affect overall reproductive performance but it did improve milk production.
First Service Calving Rates In Irish Dairy Herds: Trends From 1991-1996
Authors: O'Farrell KJ , Crilly J
Published: May 2019

In Ireland, surveys in the 1970's have shown calving rates to first service of 60-69%. Since then genetic merit and milk yield per cow have increased significantly. The objectives of this study were to determine calving rates in Irish dairy herds for the period 1991-1996 and if these had declined over time. Breeding records for 58 Spring calving commercial dairy herds maintained on the computerised DAIRYMIS System were analysed. Inseminations were categorised as either DIY AI (DIY), commercial AI (COM) or Natural Service (NAT). Between 1991 and 1996 there was a significant trend towards DIY (P<0.01) and away from NAT (P<0.01) with no consistent trend in COM usage. In 1991, roughly one third of services were to each of the three service methods but by 1996 DIY accounted for nearly 50% of all services. A subset of 34 herds, which had been present for at least five of the six years between 1991 and 1996, was used in the calving rate analysis. Calving rates to first service for DIY (48.4%) and NAT (46.0%) were not significantly different although both were significantly lower (P<0.001) than those for COM (54.5%). For small (<65), medium (65-128) and large herds (˃128) the respective proportion of services in each category were 22%, 44% and 34%. The respective calving rates of 55.2%, 51.6% and 45.7% declined significantly as herd size increased For all service types, there was a significant (P<0.001) decline in first service calving rate over time. The increased usage of DIY, combined with its lower fertility rates, would appear to be one factor responsible for the reduction in calving rate for 1991-1996 period.
Hardy's Theorem for simply connected nilpotent Lie groups
Authors: KANIUTH EBERHARD , KUMAR AJAY
Published: May 2019

We prove an analogue of Hardy's Theorem for Fourier transform pairs in ℝ for
arbitrary simply connected nilpotent Lie groups, thus extending earlier work on ℝn
and the Heisenberg groups ℍn.
Modeling V1 neuronal responses to orientation disparity
Authors: BRIDGE H. , CUMMING B.G. , PARKER A.J.
Published: May 2019

The contribution of interocular orientation differences to
depth perception, at either the neuronal or the psychophysical
level, is unclear. To understand the responses of binocular
neurons to orientation disparity, we extended the energy model
of Ohzawa et al. (1990) to incorporate binocular differences
in receptive-field orientation. The responses of the model to
grating stimuli with interocular orientation differences were
examined, along with the responses to random dot stereograms
(RDS) depicting slanted surfaces. The responses to combinations
of stimulus orientations in the two eyes were left–right
separable, which means there was no consistent response to the
binocular orientation difference. All existing neuronal data
concerning orientation disparity can be well described by this
type of model (even a version with no disparity selectivity).
The disparity sensitive model is nonetheless sensitive to changes
in RDS slant, although it requires narrow orientation bandwidth
to produce substantial modulation. The disparity-insensitive
model shows no selectivity to slant in this stimulus. Several
modifications to the model were attempted to improve its
selectivity for orientation disparity and/or slant. A model
built by summing several disparity-sensitive models showed
left–right inseparable responses, responding maximally
to a consistent orientation difference. Despite this property,
the selectivity for slant in RDS stimuli was no better than
the simple disparity-selective model. The range of models evaluated
here demonstrate that interocular orientation differences are
neither necessary nor sufficient for signaling slant. In contrast,
within the framework of the energy model, positional disparity
sensitivity appears to be both necessary and sufficient.
The Impact of Inventory on Tuna Price: An Application of Scaling in the Rotterdam Inverse Demand System
Authors: Chiang Fu-Sung , Lee Jonq-Ying , Brown Mark G.
Published: May 2019

This study adopted the scaling approach to examine the impacts of inventories on tuna auction prices in Japan using the Rotterdam inverse demand system. The inclusion of two inventory variables in the model only increases the number of parameters by two. Results indicate that frozen tunas are more likely to be close substitutes, fresh and frozen tunas of the same species are also likely to be substitutes, and inventory had significant impacts on auction prices.
Mules in Southern Agriculture: Revisited
Authors: Garrett Martin A.
Published: May 2019

This article provides additional empirical evidence concerning the choice of the mule as the dominant draft animal in southern agricultural production in the latter 19th and early 20th century. While the mule was uniquely suited to the crops and climate of the region, two divergent arguments have been presented as to why the mule was the dominant draft animal in southern agricultural production. This research reevaluates these arguments and provides evidence that it was, in fact, the characteristics of this hybrid that made it the preferred draft animal for the South.
Using network analysis to explore cognitive domains in patients with unipolar versus bipolar depression: a prospective naturalistic study
Authors: Galimberti Cesare , Bosi Monica Francesca , Caricasole Valentina , Zanello Riccardo , Dell’Osso Bernardo , Viganò Caterina Adele
Published: May 2019

Objective.

Despite growing evidence in the field of cognitive function in mood disorders, the neurocognitive profiles of patients with unipolar and bipolar depression still need further characterization. In this study, we applied network analysis, hypothesizing this approach could highlight differences between major depressive disorder (MDD) and bipolar disorder (BD) from a cognitive perspective.

Methods.

The cognitive performance of 109 patients (72 unipolar and 37 bipolar depressed outpatients) was assessed through the Montreal Cognitive Assessment (MoCA), and a series of clinical variables were collected. Differences in cognitive performance between MDD and BD patients were tested using non-parametric tests. Moreover, a network graph representing MoCA domains as nodes and Spearman’s rho correlation coefficients between the domains as edges was constructed for each group.

Results.

The presence of mild cognitive impairment was observed in both MDD and BD patients during depression. No statistical significant difference was found between the two groups in terms of overall cognitive performance and across single domains. Nonetheless, network analytic metrics demonstrated different roles of memory and executive dysfunction in MDD versus BD patients: in particular, MDD network was more densely interconnected than BD network, and memory was the node with the highest betweenness and closeness centrality in MDD, while executive function was more central in BD.

Conclusions.

From a network analytic perspective, memory impairment displays a central role in the cognitive impairment of patients with unipolar depression, whereas executive dysfunction appears to be more central in bipolar depression. Further research is warranted to confirm our results.
Intake, growth and carcass characteristics of young ostriches given concentrates with and without pasture
Authors: Nitzan R. , Barkai D. , Nitsan Z. , Landau1 S.
Published: May 2019

Although ostriches are herbivores, their diets in commercial farming in Israel consist mainly of concentrates. The objective of this study was to evaluate an alternative for fattening ostriches aged 10 to 30 weeks, which combines pasture with concentrate feeding. Chicks were allotted to three treatments. Diet of group C40 consisted of concentrate only, provided at 40 g/kg body mass (mb). Groups CG20 and CG30 received concentrate at 20 and 30 g/ kg mb, respectively, and grazed 4 to 6 h/day on lush green alfalfa (Medicago sativa), sown barley (Hordeum vulgare), natural pasture or sulla (Hedysarum coronarium). During the last 10 weeks of experiment, groups CG20 and CG30 were merged into one group, managed as CG20 and grazed natural pasture, sulla, alfalfa, or vetch (Vicia sativa). Ostriches from group CG20 and CG30 consumed 390 (s.e.30) g and 260 (s.e. 20) g DM per day at pasture, i.e. 0·46 and 0·28 of their total daily intake, respectively. Pasture intake for CG20 was higher (P < 0·05) than for CG30. Intake of pasture (both grazing treatments combined) was twice as much as on natural pasture or alfalfa as on barley. These results were consistent with the ostriches’ preference for forbs rather than grasses in the natural pasture. The mean organic matter digestibility was 0·84 (s.e. 0·01), ostriches gained at 347 (s.e. 13) g/day, and the food conversion ratio was 3·05 (s.e. 0·16), with no effect of group. Also, grazing did not affect the dressing rate (0·47, s.e. 0·015) or the size and mass of the different parts of the gastro-intestinal tract, with the exception of the glandular and muscular stomachs, which were proportionately 0·4 (P < 0·05) heavier in grazing birds. Lower (P < 0·05) fat content (33·8 v. 26·5 g/kg) but not tenderness, of a selected muscle (fibularis longus) was found for grazing birds. This study suggests that, in young ostriches, grazing lush green pasture may reduce concentrate intake by proportionately 0·4, without altering growth performance or carcass yield and quality.
The stability of a near-adiabatic Endex batch CSTR reactor
Authors: Mcintosh A. C. , Gray B. F. , Wake G. C. , Ball R.
Published: May 2019

Many tens of serious incidents involving reactors occur in the developed countries each year. The disaster at the chemical plant in Bhopal, India in 1984 was particularly notable where a thermal runaway process led to more than 3000 tragic fatalities from the cloud of extremely toxic methyl isocyanate that boiled out of a storage tank. This signalled the design of special types of chemical reactors to reduce the risk of thermal runaway by planning (at the design stage) integral safety and thermal stabilization mechanisms. The Endex CSTR (continuously stirred tank reactor) proposed by Gray and Ball [3] involves a reactor in two parts with heat exchange allowed between them. The two parts of the reactor operate side by side in tandem, such that the thermal runaway of one part is offset by an endothermic reaction in the other reactor—hence the term ‘endex’.

It is found that the adiabatic endex system has a large region of parameter space where the operation can be made safe. However adiabatic conditions rely on the continuous supply of reactants to the endothermic side of the reactor, for operation of the system. The risks involved are such that it is always safer to operate batch reactors in a non-adiabatic mode. Thus we consider the limiting case of the approach to adiabatic conditions where although the mathematics produces no oscillatory causes for instability, yet there is a narrow but significant area where the stable solution branch is lost and consequently a persistent and unexpected region of instability in what otherwise appears to be a simple CSTR system.
The Effect of the Menstrual Cycle on Daily Measures of Heart Rate Variability in Athletic Women
Authors: Kokts-Porietis Renée L. , Minichiello Nathaniel R. , Doyle-Baker Patricia K.
Published: May 2019

Abstract. Heart rate variability (HRV) is a biomarker used to reflect both healthy and pathological state(s). The effect of the menstrual cycle and menstrual cycle phases (follicular, luteal) on HRV remains unclear. Active eumenorrheic women free from exogenous hormones completed five consecutive weeks of daily, oral basal body temperature (BBT) and HRV measurements upon waking. Descriptive statistics were used to characterize shifts in the HRV measures: standard deviation of NN intervals (SDNN), root mean square of successive difference (rMSSD), high (HF) and low frequency (LF) across the menstrual cycle and between phases. All HRV measures were assessed by medians ( Mdn), median difference of consecutive days ( Mdn∆) and variance. Seven participants ( M ±  SD; age: 28.60 ± 8.40 year) completed the study with regular menstrual cycles (28.40 ± 2.30 days; ovulation day 14.57 ± 0.98 day). Median rMSSD displayed a nonlinear decrease across the menstrual cycle and plateau around the day of ovulation. A negative shift before ovulation in Mdn∆, rMSSD, SDNN, and LF as well as peak on luteal phase Day 4 in rMSSD and SDNN was observed. Median variance increased in rMSSD (150.06 ms2) SDNN (271.12 ms2), and LF variance (0.001 sec2/Hz) from follicular to luteal phase. Daily HRV associated with the parasympathetic nervous system was observed to decrease nonlinearly across the menstrual cycle.
Internalizing Problems and Attentional Control
Authors: Andersen Tonje Grønning , Fiskum Charlotte , Aslaksen Per Matti , Flaten Magne Arve , Jacobsen Karl Henry
Published: May 2019

Abstract. Individuals with internalizing problems differ in levels of attentional control (AC), and this heterogeneity could be associated with differences in autonomic arousal. The present study investigated whether AC moderated the effect of internalizing problems on self-reported experience and autonomic nervous system (ANS) responses after the induction of negative affect. Children aged 9–13 years were recruited into a patient group (29) and a healthy control group (25). AC was measured by the Early Adolescent Temperament Questionnaire. Heart rate, heart rate variability (HRV) and pre-ejection period (PEP) were recorded during baseline, a sad film clip and recovery, and analyzed using a marginal linear model. Children reported their experienced emotion, valence, and arousal in response to the film. A significant interaction effect showed increased HRV and longer PEP from baseline to recovery for patients with higher AC. Patients with lower AC showed increased HRV followed by a return to baseline values after the film clip and no significant changes in PEP. Healthy controls showed no significant changes in HRV or PEP independent of level of AC. There were no differences between groups in self-reported experience. The results indicate that AC moderated the effect of internalizing problems on ANS regulation. Increased HRV and longer PEP from baseline to recovery were uniquely associated with higher AC and internalizing problems. This physiological response might indicate a cognitive avoidance strategy. AC could be an important factor explaining heterogeneity in ANS activity among individuals with internalizing problems. Clinical implications of the present findings are discussed.
Identifying the Molecular Signatures of Agricultural Expansion in Amazonian Headwater Streams
Authors: Spencer Robert G.M. , Kellerman Anne M. , Podgorski David C. , Macedo Marcia N. , Jankowski KathiJo , Nunes Darlisson , Neill Christopher
Published: May 2019

Agricultural impacts on aquatic ecosystems are well studied; however, most research has focused on temperate regions, whereas the forefront of agricultural expansion is currently in the tropics. At the vanguard of this growth is the boundary between the Amazon and Cerrado biomes in Brazil, driven primarily by expansion of soybean and corn croplands. Here we examine the impacts of cropland expansion on receiving lowland Amazon Basin headwater streams in terms of dissolved organic carbon (DOC) concentration and dissolved organic matter (DOM) composition via ultrahigh‐resolution mass spectrometry. Streams draining croplands had lower DOC concentrations and DOM molecular signatures enriched in N‐ and S‐containing formula in comparison to forested streams. Cropland streams were also enriched in aliphatic, peptide‐like, and highly unsaturated and phenolic (low O/C) compound categories in comparison to forest streams (enriched in polyphenolics, condensed aromatics, and highly unsaturated and phenolic [high O/C] compound categories) indicative of the shifting of sources from organic‐rich surface soils and litter layers to autochthonous and more microbial biomass. Distinct molecular assemblages were strongly correlated with cropland and forest catchments, highlighting headwater streams as sentinels for detecting change. On investigation of unique molecular formulae present in only cropland sites, four cropland markers provided the ability to track agricultural impacts in the region. Overall, these patterns indicate reduced organic matter inputs in croplands and greater microbial degradation at these sites leading to declining DOC concentrations, and DOM of more microbial character in receiving streams that is more biolabile, with clear ramifications for downstream ecology and biogeochemical cycles.
RETRACTED ARTICLE: RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail
Authors: Lin Xinyao , Chai Guoshi , Wu Yingmin , Li Jiexin , Chen Feng , Liu Jianzhao , Luo Guanzheng , Tauler Jordi , Du Jun , Lin Shuibin , He Chuan , Wang Hongsheng
Published: May 2019

N6-Methyladenosine (m6A) modification has been implicated in the progression of several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one important step for cancer cell metastasis, m6A modification of mRNAs increases in cancer cells. Deletion of methyltransferase-like 3 (METTL3) down-regulates m6A, impairs the migration, invasion and EMT of cancer cells both in vitro and in vivo. m6A-sequencing and functional studies confirm that Snail, a key transcription factor of EMT, is involved in m6A-regulated EMT. m6A in Snail CDS, but not 3’UTR, triggers polysome-mediated translation of Snail mRNA in cancer cells. Loss and gain functional studies confirm that YTHDF1 mediates m6A-increased translation of Snail mRNA. Moreover, the upregulation of METTL3 and YTHDF1 act as adverse prognosis factors for overall survival (OS) rate of liver cancer patients. Our study highlights the critical roles of m6A on regulation of EMT in cancer cells and translation of Snail during this process.
BOLD5000, a public fMRI dataset while viewing 5000 visual images
Authors: Chang Nadine , Pyles John A. , Marcus Austin , Gupta Abhinav , Tarr Michael J. , Aminoff Elissa M.
Published: May 2019

Vision science, particularly machine vision, has been revolutionized by introducing large-scale image datasets and statistical learning approaches. Yet, human neuroimaging studies of visual perception still rely on small numbers of images (around 100) due to time-constrained experimental procedures. To apply statistical learning approaches that include neuroscience, the number of images used in neuroimaging must be significantly increased. We present BOLD5000, a human functional MRI (fMRI) study that includes almost 5,000 distinct images depicting real-world scenes. Beyond dramatically increasing image dataset size relative to prior fMRI studies, BOLD5000 also accounts for image diversity, overlapping with standard computer vision datasets by incorporating images from the Scene UNderstanding (SUN), Common Objects in Context (COCO), and ImageNet datasets. The scale and diversity of these image datasets, combined with a slow event-related fMRI design, enables fine-grained exploration into the neural representation of a wide range of visual features, categories, and semantics. Concurrently, BOLD5000 brings us closer to realizing Marr’s dream of a singular vision science–the intertwined study of biological and computer vision.
The effects of chiropractic spinal manipulation on central processing of tonic pain - a pilot study using standardized low-resolution brain electromagnetic tomography (sLORETA)
Authors: Navid Muhammad Samran , Lelic Dina , Niazi Imran Khan , Holt Kelly , Mark Esben Bolvig , Drewes Asbjørn Mohr , Haavik Heidi
Published: May 2019

The objectives of the study were to investigate changes in pain perception and neural activity during tonic pain due to altered sensory input from the spine following chiropractic spinal adjustments. Fifteen participants with subclinical pain (recurrent spinal dysfunction such as mild pain, ache or stiffness but with no pain on the day of the experiment) participated in this randomized cross-over study involving a chiropractic spinal adjustment and a sham session, separated by 4.0 ± 4.2 days. Before and after each intervention, 61-channel electroencephalography (EEG) was recorded at rest and during 80 seconds of tonic pain evoked by the cold-pressor test (left hand immersed in 2 °C water). Participants rated the pain and unpleasantness to the cold-pressor test on two separate numerical rating scales. To study brain sources, sLORETA was performed on four EEG frequency bands: delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz) and beta (12–32 Hz). The pain scores decreased by 9% after the sham intervention (p < 0.05), whereas the unpleasantness scores decreased by 7% after both interventions (p < 0.05). sLORETA showed decreased brain activity following tonic pain in all frequency bands after the sham intervention, whereas no change in activity was seen after the chiropractic spinal adjustment session. This study showed habituation to pain following the sham intervention, with no habituation occurring following the chiropractic intervention. This suggests that the chiropractic spinal adjustments may alter central processing of pain and unpleasantness.
QAOA for Max-Cut requires hundreds of qubits for quantum speed-up
Authors: Guerreschi G. G. , Matsuura A. Y.
Published: May 2019

Computational quantum technologies are entering a new phase in which noisy intermediate-scale quantum computers are available, but are still too small to benefit from active error correction. Even with a finite coherence budget to invest in quantum information processing, noisy devices with about 50 qubits are expected to experimentally demonstrate quantum supremacy in the next few years. Defined in terms of artificial tasks, current proposals for quantum supremacy, even if successful, will not help to provide solutions to practical problems. Instead, we believe that future users of quantum computers are interested in actual applications and that noisy quantum devices may still provide value by approximately solving hard combinatorial problems via hybrid classical-quantum algorithms. To lower bound the size of quantum computers with practical utility, we perform realistic simulations of the Quantum Approximate Optimization Algorithm and conclude that quantum speedup will not be attainable, at least for a representative combinatorial problem, until several hundreds of qubits are available.
Electrical detection of current generated spin in topological insulator surface states: Role of interface resistance
Authors: Li C. H. , van ‘t Erve O. M. J. , Yan C. , Li L. , Jonker B. T.
Published: May 2019

Current generated spin polarization in topological insulator (TI) surface states due to spin-momentum locking has been detected recently using ferromagnet/tunnel barrier contacts, where the projection of the TI spin onto the magnetization of the ferromagnet is measured as a voltage. However, opposing signs of the spin voltage have been reported, which had been tentatively attributed to the coexistence of trivial two-dimensional electron gas states on the TI surface which may exhibit opposite current-induced polarization than that of the TI Dirac surface states. Models based on electrochemical potential have been presented to determine the sign of the spin voltage expected for the TI surface states. However, these models neglect critical experimental parameters which also affect the sign measured. Here we present a Mott two-spin current resistor model which takes into account these parameters such as spin-dependent interface resistances, and show that such inclusion can lead to a crossing of the voltage potential profiles for the spin-up and spin-down electrons within the channel, which can lead to measured spin voltages of either sign. These findings offer a resolution of the ongoing controversy regarding opposite signs of spin signal reported in the literature, and highlight the importance of including realistic experimental parameters in the model.
Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila
Authors: Xu Yanjun , Borcherding Annika F. , Heier Christoph , Tian Gu , Roeder Thomas , Kühnlein Ronald P.
Published: May 2019

Obesity is a progressive, chronic disease, which can be caused by long-term miscommunication between organs. It remains challenging to understand how chronic dysfunction in a particular tissue remotely impairs other organs to eventually imbalance organismal energy homeostasis. Here we introduce RNAi Pulse Induction (RiPI) mediated by short hairpin RNA (shRiPI) or double-stranded RNA (dsRiPI) to generate chronic, organ-specific gene knockdown in the adult Drosophila fat tissue. We show that organ-restricted RiPI targeting Stromal interaction molecule (Stim), an essential factor of store-operated calcium entry (SOCE), results in progressive fat accumulation in fly adipose tissue. Chronic SOCE-dependent adipose tissue dysfunction manifests in considerable changes of the fat cell transcriptome profile, and in resistance to the glucagon-like Adipokinetic hormone (Akh) signaling. Remotely, the adipose tissue dysfunction promotes hyperphagia likely via increased secretion of Akh from the neuroendocrine system. Collectively, our study presents a novel in vivo paradigm in the fly, which is widely applicable to model and functionally analyze inter-organ communication processes in chronic diseases.
The structural arrangement at intersubunit interfaces in homomeric kainate receptors
Authors: Litwin Douglas B. , Carrillo Elisa , Shaikh Sana A. , Berka Vladimir , Jayaraman Vasanthi
Published: May 2019

Kainate receptors are glutamate-gated cation-selective channels involved in excitatory synaptic signaling and are known to be modulated by ions. Prior functional and structural studies suggest that the dimer interface at the agonist-binding domain plays a key role in activation, desensitization, and ion modulation in kainate receptors. Here we have used fluorescence-based methods to investigate the changes and conformational heterogeneity at these interfaces associated with the resting, antagonist-bound, active, desensitized, and ion-modulated states of the receptor. These studies show that in the presence of Na+ ions the interfaces exist primarily in the coupled state in the apo, antagonist-bound and activated (open channel) states. Under desensitizing conditions, the largely decoupled dimer interface at the agonist-binding domain as seen in the cryo-EM structure is one of the states observed. However, in addition to this state there are several additional states with lower levels of decoupling. Replacing Na+ with Cs+ does not alter the FRET efficiencies of the states significantly, but shifts the population to the more decoupled states in both resting and desensitized states, which can be correlated with the lower activation seen in the presence of Cs+.
A practical adaptive moving-mesh algorithm for solving unconfined seepage problem with Galerkin finite element method
Authors: Dai Qianwei , Lei Yi , Zhang Bin , Feng Deshan , Wang Xun , Yin Xiaobo
Published: May 2019

One of the great challenges of unconfined seepage through a dam lies in the accurate determination of free surface that depends on the complexity of the seepage model, especially if the model is characterized with complex geometry and sharp variations in permeability distribution. This study presents a practical methodology that combines the adaptive moving-mesh algorithm and the Galerkin finite element method (FEM) to solve an unconfined seepage problem with high efficiency and precision. The methodology employs a set of improvement terms, such as remainder factor, step-size parameter and termination condition, all of which guarantee that the simulation and the refinement fitting can be implemented efficiently until the free surface converges within a given allowable error. In particular, a specialized discussion is presented for the significant relation between the location of the exit point and the corresponding grid fineness. To validate the practicability of the proposed method, a series of examples are performed. Comparing the result with those of other numerical approaches, we conclude that even though the unconfined seepage model may be complicated with arbitrary complex geometry and sharp variations in permeability distribution, the proposed algorithm provides a great improvement in efficiency and accuracy in free-surface searching.