bluuebunny/crossref_metadata_2025 huggingface dataset:
Somatostatin Receptor Splicing Variant sst5TMD4 Overexpression in Glioblastoma Is Associated with Poor Survival, Increased Aggressiveness Features, and Somatostatin Analogs Resistance
Authors: Fuentes-Fayos Antonio C. , G-García Miguel E. , Pérez-Gómez Jesús M. , Peel Annabel , Blanco-Acevedo Cristóbal , Solivera Juan , Ibáñez-Costa Alejandro , Gahete Manuel D. , Castaño Justo P. , Luque Raúl M.
Published: January 2022

Glioblastoma (GBM) is the most malignant and lethal brain tumor. Current standard treatment consists of surgery followed by radiotherapy/chemotherapy; however, this is only a palliative approach with a mean post-operative survival of scarcely ~12–15 months. Thus, the identification of novel therapeutic targets to treat this devastating pathology is urgently needed. In this context, the truncated splicing variant of the somatostatin receptor subtype 5 (sst5TMD4), which is produced by aberrant alternative splicing, has been demonstrated to be overexpressed and associated with increased aggressiveness features in several tumors. However, the presence, functional role, and associated molecular mechanisms of sst5TMD4 in GBM have not been yet explored. Therefore, we performed a comprehensive analysis to characterize the expression and pathophysiological role of sst5TMD4 in human GBM. sst5TMD4 was significantly overexpressed (at mRNA and protein levels) in human GBM tissue compared to non-tumor (control) brain tissue. Remarkably, sst5TMD4 expression was significantly associated with poor overall survival and recurrent tumors in GBM patients. Moreover, in vitro sst5TMD4 overexpression (by specific plasmid) increased, whereas sst5TMD4 silencing (by specific siRNA) decreased, key malignant features (i.e., proliferation and migration capacity) of GBM cells (U-87 MG/U-118 MG models). Furthermore, sst5TMD4 overexpression in GBM cells altered the activity of multiple key signaling pathways associated with tumor aggressiveness/progression (AKT/JAK-STAT/NF-κB/TGF-β), and its silencing sensitized GBM cells to the antitumor effect of pasireotide (a somatostatin analog). Altogether, these results demonstrate that sst5TMD4 is overexpressed and associated with enhanced malignancy features in human GBMs and reveal its potential utility as a novel diagnostic/prognostic biomarker and putative therapeutic target in GBMs.
Deep Functional Profiling of Wild Animal Microbiomes Reveals Probiotic Bacillus pumilus Strains with a Common Biosynthetic Fingerprint
Authors: Baranova Margarita N. , Kudzhaev Arsen M. , Mokrushina Yuliana A. , Babenko Vladislav V. , Kornienko Maria A. , Malakhova Maja V. , Yudin Victor G. , Rubtsova Maria P. , Zalevsky Arthur , Belozerova Olga A. , Kovalchuk Sergey , Zhuravlev Yuriy N. , Ilina Elena N. , Gabibov Alexander G. , Smirnov Ivan V. , Terekhov Stanislav S.
Published: January 2022

The biodiversity of microorganisms is maintained by intricate nets of interactions between competing species. Impaired functionality of human microbiomes correlates with their reduced biodiversity originating from aseptic environmental conditions and antibiotic use. Microbiomes of wild animals are free of these selective pressures. Microbiota provides a protecting shield from invasion by pathogens in the wild, outcompeting their growth in specific ecological niches. We applied ultrahigh-throughput microfluidic technologies for functional profiling of microbiomes of wild animals, including the skin beetle, Siberian lynx, common raccoon dog, and East Siberian brown bear. Single-cell screening of the most efficient killers of the common human pathogen Staphylococcus aureus resulted in repeated isolation of Bacillus pumilus strains. While isolated strains had different phenotypes, all of them displayed a similar set of biosynthetic gene clusters (BGCs) encoding antibiotic amicoumacin, siderophore bacillibactin, and putative analogs of antimicrobials including bacilysin, surfactin, desferrioxamine, and class IId cyclical bacteriocin. Amicoumacin A (Ami) was identified as a major antibacterial metabolite of these strains mediating their antagonistic activity. Genome mining indicates that Ami BGCs with this architecture subdivide into three distinct families, characteristic of the B. pumilus, B. subtilis, and Paenibacillus species. While Ami itself displays mediocre activity against the majority of Gram-negative bacteria, isolated B. pumilus strains efficiently inhibit the growth of both Gram-positive S. aureus and Gram-negative E. coli in coculture. We believe that the expanded antagonistic activity spectrum of Ami-producing B. pumilus can be attributed to the metabolomic profile predetermined by their biosynthetic fingerprint. Ultrahigh-throughput isolation of natural probiotic strains from wild animal microbiomes, as well as their metabolic reprogramming, opens up a new avenue for pathogen control and microbiome remodeling in the food industry, agriculture, and healthcare.
Evidence for Inhibitory Perturbations on the Amplitude, Gating, and Hysteresis of A-Type Potassium Current, Produced by Lacosamide, a Functionalized Amino Acid with Anticonvulsant Properties
Authors: Cho Hsin-Yen , Chuang Tzu-Hsien , Wu Sheng-Nan
Published: January 2022

Lacosamide (Vimpat®, LCS) is widely known as a functionalized amino acid with promising anti-convulsant properties; however, adverse events during its use have gradually appeared. Despite its inhibitory effect on voltage-gated Na+ current (INa), the modifications on varying types of ionic currents caused by this drug remain largely unexplored. In pituitary tumor (GH3) cells, we found that the presence of LCS concentration-dependently decreased the amplitude of A-type K+ current (IK(A)) elicited in response to membrane depolarization. The IK(A) amplitude in these cells was sensitive to attenuation by the application of 4-aminopyridine, 4-aminopyridine-3-methanol, or capsaicin but not by that of tetraethylammonium chloride. The effective IC50 value required for its reduction in peak or sustained IK(A) was calculated to be 102 or 42 µM, respectively, while the value of the dissociation constant (KD) estimated from the slow component in IK(A) inactivation at varying LCS concentrations was 52 µM. By use of two-step voltage protocol, the presence of this drug resulted in a rightward shift in the steady-state inactivation curve of IK(A) as well as in a slowing in the recovery time course of the current block; however, no change in the gating charge of the inactivation curve was detected in its presence. Moreover, the LCS addition led to an attenuation in the degree of voltage-dependent hysteresis for IK(A) elicitation by long-duration triangular ramp voltage commands. Likewise, the IK(A) identified in mouse mHippoE-14 neurons was also sensitive to block by LCS, coincident with an elevation in the current inactivation rate. Collectively, apart from its canonical action on INa inhibition, LCS was effective at altering the amplitude, gating, and hysteresis of IK(A) in excitable cells. The modulatory actions on IK(A), caused by LCS, could interfere with the functional activities of electrically excitable cells (e.g., pituitary tumor cells or hippocampal neurons).
How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics
Authors: Suda Kazunori , Matsuda Kazunori
Published: January 2022

Accumulating evidence suggests that the gut microbiome influences the brain functions and psychological state of its host via the gut–brain axis, and gut dysbiosis has been linked to several mental illnesses, including major depressive disorder (MDD). Animal experiments have shown that a depletion of the gut microbiota leads to behavioral changes, and is associated with pathological changes, including abnormal stress response and impaired adult neurogenesis. Short-chain fatty acids such as butyrate are known to contribute to the up-regulation of brain-derived neurotrophic factor (BDNF), and gut dysbiosis causes decreased levels of BDNF, which could affect neuronal development and synaptic plasticity. Increased gut permeability causes an influx of gut microbial components such as lipopolysaccharides, and the resultant systemic inflammation may lead to neuroinflammation in the central nervous system. In light of the fact that gut microbial factors contribute to the initiation and exacerbation of depressive symptoms, this review summarizes the current understanding of the molecular mechanisms involved in MDD onset, and discusses the therapeutic potential of probiotics, including butyrate-producing bacteria, which can mediate the microbiota–gut–brain axis.
Amino Acids and IGF1 Regulation of Fish Muscle Growth Revealed by Transcriptome and microRNAome Integrative Analyses of Pacu (Piaractus mesopotamicus) Myotubes
Authors: Duran Bruno Oliveira Silva , Zanella Bruna Tereza Thomazini , Perez Erika Stefani , Mareco Edson Assunção , Blasco Josefina , Dal-Pai-Silva Maeli , Garcia de la serrana Daniel
Published: January 2022

Amino acids (AA) and IGF1 have been demonstrated to play essential roles in protein synthesis and fish muscle growth. The myoblast cell culture is useful for studying muscle regulation, and omics data have contributed enormously to understanding its molecular biology. However, to our knowledge, no study has performed the large-scale sequencing of fish-cultured muscle cells stimulated with pro-growth signals. In this work, we obtained the transcriptome and microRNAome of pacu (Piaractus mesopotamicus)-cultured myotubes treated with AA or IGF1. We identified 1228 and 534 genes differentially expressed by AA and IGF1. An enrichment analysis showed that AA treatment induced chromosomal changes, mitosis, and muscle differentiation, while IGF1 modulated IGF/PI3K signaling, metabolic alteration, and matrix structure. In addition, potential molecular markers were similarly modulated by both treatments. Muscle-miRNAs (miR-1, -133, -206 and -499) were up-regulated, especially in AA samples, and we identified molecular networks with omics integration. Two pairs of genes and miRNAs demonstrated a high-level relationship, and involvement in myogenesis and muscle growth: marcksb and miR-29b in AA, and mmp14b and miR-338-5p in IGF1. Our work helps to elucidate fish muscle physiology and metabolism, highlights potential molecular markers, and creates a perspective for improvements in aquaculture and in in vitro meat production.
Latrotoxin-Induced Neuromuscular Junction Degeneration Reveals Urocortin 2 as a Critical Contributor to Motor Axon Terminal Regeneration
Authors: D’Este Giorgia , Stazi Marco , Negro Samuele , Megighian Aram , Lista Florigio , Rossetto Ornella , Montecucco Cesare , Rigoni Michela , Pirazzini Marco
Published: January 2022

We used α-Latrotoxin (α-LTx), the main neurotoxic component of the black widow spider venom, which causes degeneration of the neuromuscular junction (NMJ) followed by a rapid and complete regeneration, as a molecular tool to identify by RNA transcriptomics factors contributing to the structural and functional recovery of the NMJ. We found that Urocortin 2 (UCN2), a neuropeptide involved in the stress response, is rapidly expressed at the NMJ after acute damage and that inhibition of CRHR2, the specific receptor of UCN2, delays neuromuscular transmission rescue. Experiments in neuronal cultures show that CRHR2 localises at the axonal tips of growing spinal motor neurons and that its expression inversely correlates with synaptic maturation. Moreover, exogenous UCN2 enhances the growth of axonal sprouts in cultured neurons in a CRHR2-dependent manner, pointing to a role of the UCN2-CRHR2 axis in the regulation of axonal growth and synaptogenesis. Consistently, exogenous administration of UCN2 strongly accelerates the regrowth of motor axon terminals degenerated by α-LTx, thereby contributing to the functional recovery of neuromuscular transmission after damage. Taken together, our results posit a novel role for UCN2 and CRHR2 as a signalling axis involved in NMJ regeneration.
The Effect of the Addition of Hazelnut or Walnut Flour on the Rheological Characteristics of Wheat Dough
Authors: Pycia Karolina , Juszczak Lesław
Published: January 2022

The aim of this study was to evaluate the effect of the addition of hazelnut or walnut flour on the rheological properties of flour and wheat dough (WD). The research material was a system in which wheat flour was replaced with flour based on hazelnuts (HF) or walnuts (WF), i.e., nut flour, in the amounts of 5%, 10% and 15% (WDH, WDW). As a part of the research methodology, we analysed the wet gluten content, and farinographic and extensographic analyses of the dough were performed. Sweep frequency, creep and recovery tests were used to assess the viscoelastic properties of the tested doughs. It was found that the doughs with the addition of walnuts were characterized by different rheological properties compared to the control sample. The systems in which wheat flour was replaced with nuts were characterized by lower water absorption, and this parameter decreased as the share of nuts in the system increased. The mean value of this parameter for WDH was 48.6%, and in the case of WDW it was 47.9%. The development times of WDH and WDW doughs were longer compared to the control, but they decreased as the addition of nut flour was increased. The WDH doughs were characterized by the lowest stability and the highest degree of softening among the examined doughs. It was shown that the addition of nut flour reduced the values of the storage (G′) and loss (G″) modules characterizing the tested doughs, while in each case the G′ value was greater than the G″ value, which proves the advantage of the elastic properties. The creep and recovery tests showed that the nut dough was more susceptible to deformation compared to the control, which indicates that the presence of nut flour weakens the formation of the gluten network forming the dough structure, and makes it more susceptible to stress.
Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis
Authors: Ju Yuhao , Shan Kai , Liu Wenlin , Xi Chenxiang , Zhang Yiling , Wang Wei , Wang Chunlei , Cao Ruiwen , Zhu Wenxing , Wang Haiyong , Zhao Yanqiu , Hao Lujiang
Published: January 2022

Exopolysaccharides (EPSs) are carbohydrate polymers produced and secreted by microorganisms. In a changing marine environment, EPS secretion can reduce damage from external environmental disturbances to microorganisms. Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals. Changes in external environmental pH have been shown to affect the synthesis of EPSs in microorganisms. In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018. In addition, the transcriptome sequence of P. agarivorans Hao 2018 under different initial fermentation pH levels was determined. GO and KEGG analyses showed that the differentially expressed genes were concentrated in the two-component regulatory system and bacterial chemotaxis pathways. We further identified the expression of key genes involved in EPS synthesis during pH changes. In particular, the expression of genes encoding the glucose/galactose MFS transporter, phosphomannomutase, and mannose-1-phosphate guanylyltransferase was upregulated when the environmental pH increased, thus promoting EPS synthesis. This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
Regulatory Effects of Functional Soluble Dietary Fiber from Saccharina japonica Byproduct on the Liver of Obese Mice with Type 2 Diabetes Mellitus
Authors: Zhang Liping , Wang Xixi , He Yingying , Cao Junhan , Wang Kai , Lin Huan , Qu Changfeng , Miao Jinlai
Published: January 2022

Though the relationship between dietary fiber and physical health has been investigated widely, the use of dietary fiber from marine plants has been investigated relatively rarely. The Saccharina japonica byproducts after the production of algin contain a large amount of insoluble polysaccharide, which will cause a waste of resources if ignored. Soluble dietary fiber (SDF)prepared from waste byproducts of Saccharina japonica by alkaline hydrolysis method for the first time had a wrinkled microscopic surface and low crystallinity, which not only significantly reduced liver index, serum levels of aspartate aminotransferase (AST) and alanine amiotransferase (ALT), and liver fat accumulation damage to the livers of obese diabetic mice, but also activated the PI3K/AKT signaling pathway to increase liver glycogen synthesis and glycolysis. By LC-MS/MS employing a Nexera UPLC tandem QE high-resolution mass spectrometer, the 6 potential biomarker metabolites were screened, namely glycerophosphocholine (GPC), phosphocholine (PCho), pantothenic acid, glutathione (GSH), oxidized glutathione (GSSG), and betaine; several pathways of these metabolites were associated with lipid metabolism, glycogen metabolism, and amino acid metabolism in the liver were observed. This study further provided a detailed insight into the mechanisms of SDF from Saccharina japonica byproducts in regulating the livers of obese mice with type 2 diabetes and laid a reliable foundation for the further development and utilization of Saccharina japonica.
Fully Electrical Post-Fabrication Trimming of Resistive Sensors
Authors: Shankhour Ibrahim , Mohdad Jad , Mailly Frédérick , Nouet Pascal
Published: January 2022

A compact and efficient IC architecture is presented as an alternative to laser-trimmed precision thin-film resistors or look-up tables. The objective is to keep the device, such as a four-terminal Wheatstone bridge, but to compensate for post-manufacturing offset and to avoid the so-induced degradation of performances in terms of full-scale, non-linearity, power supply noise rejection and scale factor. Expected advantages are a reduced cost due to the electrical-only implementation and a possible on-field calibration of high-end sensors. Application of the proposed solution is illustrated on an example to demonstrate improvement factors on offset and sensitivity accuracy of 32 and 10, respectively. Additionally, the power supply rejection ratio is improved by 30 dB. The experimental results finally demonstrate both efficiency and versatility of the proposed solution thanks to a first silicon prototype, fabricated in a 0.35 μm Technology from AMS, connected to an off-the-shelf pressure sensor.
The EGNOS Augmentation in Maritime Navigation
Authors: Innac Anna , Angrisano Antonio , Del Pizzo Silvio , Cappello Giovanni , Gaglione Salvatore
Published: January 2022

The objective of this work is the evaluation of the performances of EGNOS (European Geostationary Navigation Overlay System) augmentation system in maritime navigation by comparing them with those obtained by other positioning methods as Single Point Positioning (SPP) and Differential Global Positioning System (DGPS). Preliminarily, EGNOS performances in an open-sky context were evaluated through static data downloaded by EGNOS RIMS (Ranging and Integrity Monitoring Stations) located in Rome. Then, for the maritime test carried out onboard a boat in the Gulf of Naples, two dual-frequency receivers were used: Xiaomi Mi 8 smartphone and u-blox ZED-F9P multi-band GNSS (Global Navigation Satellite System) receiver, both in kinematic mode. At last, IMO (International Maritime Organization) requirements, established in IMO Resolution A.1046 (27), that a SBAS (Satellite Based Augmentation System) system in particular scenarios (coastal, inland-water, harbor navigation and ocean waters) must respect, were verified.
Using GPS Collars and Sensors to Investigate the Grazing Behavior and Energy Balance of Goats Browsing in a Mediterranean Forest Rangeland
Authors: Chebli Youssef , El Otmani Samira , Hornick Jean-Luc , Keli Abdelhafid , Bindelle Jérôme , Chentouf Mouad , Cabaraux Jean-François
Published: January 2022

The Global Positioning System (GPS) and sensors technologies are increasingly used to study the grazing behavior of animals. This work was conducted to understand the grazing behavior and energy balance of goats browsing in forest rangeland using GPS and sensors technologies. Forage availability was estimated using the quadrat method during three grazing seasons. Simultaneously, eight indigenous goats were selected to explore their feeding behavior, grazing activities, and energy requirements. The experimental goats were fitted with GPS collars and leg sensors to monitor their grazing activities. At the same time, direct observation was used as a method to study their feeding behavior. Forage availability was higher during spring compared to the summer and autumn seasons. Goats recorded the highest biting rate during summer and autumn (about 22 bites/min). The highest intake rate was recorded during spring (5.6 g DM/min). During spring, goats spent most of their time on grazing (48%) in contrast to the summer and autumn (<31%; p < 0.001). They prolonged their lying down time in summer at the expense of standing duration. The time devoted exclusively to grazing (eating) was longer in spring. Walking time in summer and autumn was longer than in spring (p < 0.001). During summer and autumn, the energy balance of goats under grazing conditions was in deficit. Using GPS collars and leg sensors appears to be a useful and easily replicable method to explore and understand the seasonal changes in the grazing areas and activities of goats in a mountainous region. The results could help goat herders and managers to develop feeding and grazing systems while increasing the performance of goats in the Mediterranean forest rangeland.
A Single Sacral-Mounted Inertial Measurement Unit to Estimate Peak Vertical Ground Reaction Force, Contact Time, and Flight Time in Running
Authors: Patoz Aurélien , Lussiana Thibault , Breine Bastiaan , Gindre Cyrille , Malatesta Davide
Published: January 2022

Peak vertical ground reaction force (Fz,max), contact time (tc), and flight time (tf) are key variables of running biomechanics. The gold standard method (GSM) to measure these variables is a force plate. However, a force plate is not always at hand and not very portable overground. In such situation, the vertical acceleration signal recorded by an inertial measurement unit (IMU) might be used to estimate Fz,max, tc, and tf. Hence, the first purpose of this study was to propose a method that used data recorded by a single sacral-mounted IMU (IMU method: IMUM) to estimate Fz,max. The second aim of this study was to estimate tc and tf using the same IMU data. The vertical acceleration threshold of an already existing IMUM was modified to detect foot-strike and toe-off events instead of effective foot-strike and toe-off events. Thus, tc and tf estimations were obtained instead of effective contact and flight time estimations. One hundred runners ran at 9, 11, and 13 km/h. IMU data (208 Hz) and force data (200 Hz) were acquired by a sacral-mounted IMU and an instrumented treadmill, respectively. The errors obtained when comparing Fz,max, tc, and tf estimated using the IMUM to Fz,max, tc, and tf measured using the GSM were comparable to the errors obtained using previously published methods. In fact, a root mean square error (RMSE) of 0.15 BW (6%) was obtained for Fz,max while a RMSE of 20 ms was reported for both tc and tf (8% and 18%, respectively). Moreover, even though small systematic biases of 0.07 BW for Fz,max and 13 ms for tc and tf were reported, the RMSEs were smaller than the smallest real differences [Fz,max: 0.28 BW (11%), tc: 32.0 ms (13%), and tf: 32.0 ms (30%)], indicating no clinically important difference between the GSM and IMUM. Therefore, these results support the use of the IMUM to estimate Fz,max, tc, and tf for level treadmill runs at low running speeds, especially because an IMU has the advantage to be low-cost and portable and therefore seems very practical for coaches and healthcare professionals.
Performance Evaluation Metrics and Approaches for Target Tracking: A Survey
Authors: Song Yan , Hu Zheng , Li Tiancheng , Fan Hongqi
Published: January 2022

Performance evaluation (PE) plays a key role in the design and validation of any target-tracking algorithms. In fact, it is often closely related to the definition and derivation of the optimality/suboptimality of an algorithm such as that all minimum mean-squared error estimators are based on the minimization of the mean-squared error of the estimation. In this paper, we review both classic and emerging novel PE metrics and approaches in the context of estimation and target tracking. First, we briefly review the evaluation metrics commonly used for target tracking, which are classified into three groups corresponding to the most important three factors of the tracking algorithm, namely correctness, timeliness, and accuracy. Then, comprehensive evaluation (CE) approaches such as cloud barycenter evaluation, fuzzy CE, and grey clustering are reviewed. Finally, we demonstrate the use of these PE metrics and CE approaches in representative target tracking scenarios.
Dehydroepiandrosterone (DHEA) Improves the Metabolic and Haemostatic Disturbances in Rats with Male Hypogonadism
Authors: Safwat Sally M. , Hussein Abdelaziz M. , Eid Elsayed A. , Serria Mohamed S. , Elesawy Basem H. , Sakr Hussein F.
Published: January 2022

Objectives: The current work was designed to study the effect of dehydroepiandrosterone (DHEA) on glucose homeostasis, liver functions and hemostatic disturbances in a rat model of bilateral orchidectomy (ORCH). Methods: 32 male rats (n = 8) were randomly assigned into 4 groups; (i) control (sham operated) group; were normal rats in which all surgical procedures were done without ORCH, (ii) Control + DHEA group: as control group but rats were treated with DHEA for 12 weeks, (iii) orchiectomized (ORCH) group: rats had bilateral orchidectomy and (iv) ORCH + DHEA group: orchiectomized rats treated with DHEA for 12 weeks. Four weeks after ORCH, DHEA treatment began and lasted for twelve weeks. By the end of the experiment, the parameters of glucose homeostasis, lipid profile, liver enzymes, bleeding and clotting times (B.T. and C.T.), prothrombin time (P.T.), activated partial thromboplastin time (aPTT), platelet count and aggregation, von-Willebrand factor (vWF), fibrinogen, plasminogen activator inhibitor (PAI-1), fibrin degradation products (FDP), intercellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1), endothelin-1 were measured. Results: ORCH caused significant deteriorations in the parameters of glucose homeostasis, lipid profile, and liver functions (p < 0.05). In addition, lower androgenicity-induced by ORCH caused a significant rise in PAI-1, fibrinogen, FDPs, ET-1 (p < 0.01) with significant shortening of bleeding and clotting times. DHEA replacement therapy significantly decreased glucose, insulin, PAI-1, fibrinogen, ICAM-1, and VCAM-1 when compared to ORCH rats. Conclusion: DHEA ameliorated the metabolic, hepatic, hypercoagulable, and hypofibrinolysis disturbances induced by ORCH.
The role of the developed and developing economies in the Central Asian countries’ economic growth
Authors: Jumayev Farrukh
Published: January 2022

The current state of economic development of the countries of Central Asia is controversive. Their GDP grows faster than the global GDP, but their economies from the other hand are extremely ineffective in distribution of wealth, the use of gained resources. In order to overcome this, multiple mechanisms are created, namely the development banks and institutions, BRI, EAEU etc. These institutions represent the interests of the major regional players. The article concentrates on the interests of Asian countries and Russia, giving a glance on the mechanisms these countries use and their real power in the region. The author conducted statistical analysis, used dilogical approach to the gains and losses of the economies of Central Asia in the context of their cooperation with major players – PRC, Russia, Japan and others. The risks of such cooperation were revealed too, firstly, the risks for economic growth, but including the risks of social character. The results of the study demonstrate that the current situation is far from positive, as every positive influence is controversed by negative. In this regard, the major finding s include this controversy, the recommendations for easing the issues of economic cooperation, the practical proof of the tightening grip of PRC on the region and the weakening influence of Russia in Central Asia.
The Cinemapoetics of the modern Ukrainian novel: Myroslav Dochynets’ creative works
Authors: Horbolis Larysa , Ishchenko Olena , Novykov Anatoliy , Marieiev Dmytro , Hrychanyk Nataliya
Published: January 2022

The article presents a review of the Ukrainian literary critics’ works on the relationship between literature and cinema, the relevance and effectiveness of the practice of involving cinematic resources in the literary works of Ukrainian writers of the 20th – early 21st centuries. On the material of the novels “Centenarian. Confession on the Pass of the Spirit”, “Svitovan. Studies under the Tent of the Skies”, “Well-Digger. Diary of the Richest Resident of Mukachevo Dominion”, “Highlander. Waters of Our Lord’s Riverbeds”, “Maftei. Book Written with a Dry Pen” by the contemporary Ukrainian writer M. Dochynets traces the problem of inter-artistic interaction of literature and cinema. The purpose of the research is to single out and analyze film frame, montage, shot, perspective, rhythm as integral elements of the cinematic poetics of M. Dochynets ’prose, which are used in the text to reveal the artistic, aesthetic, philosophical and creative principles of the writer. The study used general scientific (analysis, synthesis, comparison) and literary methods: the systematic approach, hermeneutic method, principles of narratology, intermedia approach. Appealing to the works of O. Chicherin, S. Eisenstein, Yu. Lotman, M. Romm, A. Tarkovsky, etc., the peculiarities of the use of film poetics in the writer’s novels are analyzed. It was found out that in prose by M. Dochynets montage, film frame, shot, rhythm, foreshortening perform intonation-expressive, plot-compositional and characterological functions.
IMAGE ENHANCEMENT ON OBJECT DETECTION USING L0 GRADIENT PRIOR
Authors: Megawan Sunario , Gohzali Hernawati , Halim Apriyanto
Published: January 2022

Object detection is a technique used to retrieve certain parts of the image. The part can be in the form of scenery, people, or other objects. At the time of object detection, the image obtained can experience a decrease in image quality which can be caused by weather factors, namely fog, smoke, dust, rain, and others. A decrease in the quality of the image can result in errors in classification and the inability to recognize objects in the image. Therefore, the process of improving image quality becomes very important to do at the pre-processing stage in detecting image objects. The focus of the problem to be solved in this study is the return of a blurred image using L0 Gradient Prior. The results showed that the application of L0 Gradient Prior in restoring a blurred image can increase the number of objects that can be detected by the object detection system.
IMPLEMENTATION ANALYTICAL HIERARCHY PROCESS AND WEIGHTED PRODUCT METHOD FOR LOVEBIRD SELECTION IDENTIFICATION APPLICATIONS
Authors: Oktavia Yolanda Nur , Hayati Nur , Fitri Iskandar
Published: January 2022

Among the many types of birds in Indonesia, lovebirds are pets that attract the most attention and become a favorite among the public. This is evidenced by the many communities of lovebird lovers throughout Indonesia. The problem that exists for ordinary people who do not understand the animal world and have little knowledge about the quality of the lovebirds, it is not uncommon for the problem to be in doing business for sellers it is difficult to make decisions in overcoming the problem of selecting the best birds. Based on this problem, the author compares the combination of the analytical hierarchy process and weighted product methods with the analytical hierarchy process and TOPSIS from this comparison, the highest score is 392.63 on the analytical hierarchy process and weighted product for the best quality web-based lovebird selection recommendation application design application. From the results of application testing and manual calculations with 64 sample data, it was concluded that 4 users or about 6% were included in the low accuracy category in the best lovebird recommendation results, 12 users or 19% of the total tests were stated at a moderate level of accuracy in the lovebird recommendation results. The best and 48 users or 75% of the total tests were stated at the high accuracy category level in the best lovebird recommendation results with the highest accuracy value of 80.2% on the Albino lovebird type.
FORMATION OF SELF-CONSCIOUSNESS OF YOUTH: INTERRELATION OF CIVIL AND ETHNO-CULTURAL IDENTITIES (SOCIO-PHILOSOPHICAL ANALYSIS)
Authors: Нанаева Б. Б. , Сулейманова Р. Р.
Published: January 2022

В статье раскрывается сложный процесс становления современного гражданского общества в России, сопряженного с переходом страны от авторитарной организации политической жизнедеятельности к демократическому обществу, а также наметившиеся позитивные тенденции. Подчеркивается стратегическое значение формирования гражданского самосознания молодого поколения в реализации его творческого потенциала в интересах страны. На основе анализа ментальных характеристик одного из народов Северного Кавказа - чеченцев, показано, что в условиях современных социокультурных трансформаций гражданская идентичность проявляет себя в развитии политической культуры, правовом сознании, исторической памяти, патриотизме и осознании своей принадлежности к российскому сообществу народов. Учитывая включенность молодежи в общественную и культурную жизнь многонациональной страны, задача решается исходя из концепции, утвердившейся в современном обществоведении, о доминантной роли этнической идентичности, ценностей гуманизма и нравственности, составляющих ее основу.

The article reveals the complex process of formation of modern civil society in Russia, coupled with the transition of the country from the authoritarian organization of political life to a democratic society, as well as the emerging positive trends. The strategic importance of the formation of civic consciousness of the younger generation in the realization of its creative potential in the interests of the country is emphasized. Based on the analysis of the mental characteristics of one of the peoples of the North Caucasus - the Chechens, it is shown that in the conditions of modern socio-cultural transformations, civil identity manifests itself in the development of a politic culture, legal consciousness, historical memory, patriotism and awareness of its belonging to the Russian community of peoples. Taking into account the inclusion of models in the social and cultural life of a multinational country, the task is solved on the basis of the concept established in modern social science, about the dominant role of ethnic identity, the values of humanism and morality that form its basis.
DEVELOPMENT OF AN OPTIMAL METHODFOR CAPTURE OF AEROSOL SULFUR IN THE PROCESS OF DIRECT HYDROGEN SULFUR OXIDATION
Authors: Цамаева П. С. , Эльмурзаев А. А. , Колесник А. П.
Published: January 2022

Процессы переработки сероводородсодержащих газов сопровождаются получением множества проблем. В данной статье проводится исследование процесса улавливания сероводорода из попутных нефтяных газов в присутствии растворителей. Процессы прямого окисления сероводорода на опытных образцах промышленных установок требуют создания эффективных процессов выделения серы и водорода из продуктов реакции. Полученные экспериментальные данные позволяют рассчитать соотношение растворимости элементарной и аэрозольной серы в органических растворителях. Результаты исследований показали, что органические растворители можно успешно использовать для создания технологии абсорбции аэрозольной серы, выявлен ряд положительных моментов применения органических растворителей, а также достичь степень улавливания до 95%.

The processes of processing hydrogen sulfide-containing gases are accompanied by many problems. This article investigates the process of capturing hydrogen sulfide from associated petroleum gases in the presence of solvents. The processes of direct oxidation of hydrogen sulfide on prototypes of industrial plants requires the creation of efficient processes for the separation of sulfur and hydrogen from the reaction products. The experimental data obtained make it possible to calculate the ratio of the solubility of elemental and aerosol sulfur in organic solvents. The research results have shown that organic solvents can be successfully used to create a technology for the absorption of aerosol sulfur, a number of positive aspects of the use of organic solvents have been identified, as well as to achieve a collection rate of up to 95%.
NANOTECHNOLOGIES AND NANOMATERIALS
Authors: Баснукаев И. Ш. , Исламов А. А. , Мусостова Д. Ш.
Published: January 2022

На современном этапе развития науки и техники отдельной областью становится изучение нанотехнологий и наноматериалов. Частицы, имеющие размер от 1 до 100 нанометров, придают материалам новые свойства, позволяющие увеличить эффективность их применения практически во всех практических сферах. При помощи нанотехнологий создаются композиционные материалы на полимерной и металлической основах. Эти материалы имеют уникальные свойства, и их широкое применение приведет к технологической революции, которая изменит все жизненно важные области деятельности человека. В данной статье приводится общий обзор нанотехнологий и наноматериалов, рассматриваются перспективы их использования в современном мире.

At the present stage of the development of science and technology, the study of nanotechnology and nanomaterials is becoming a separate area. Particles ranging in size from 1 to 100 nanometers give materials new properties that allow increasing the efficiency of their application in almost all practical areas. Composite materials based on polymer and metal bases are created with the help of nanotechnology. These materials have unique properties, and their widespread use will lead to a technological revolution that will change all vital areas of human activity. This article provides a general overview of nanotechnology and nanomaterials, discusses the prospects for their use in the modern world
APPLICATION OF BIM TECHNOLOGIES IN THE RECONSTRUCTION OF THE 1-st FLOOR HALL OF THE GSTOU BUILDING No. 2
Authors: Успанова А. С. , Алиев С. А.
Published: January 2022

Современное проектирование невозможно представить без программных комплексов, призванных повысить эффективность строительного производства. Технологии ВIM в строительной отрасли привлекают все больше пользователей ввиду их универсальности, возможности адаптации к любым видам проектных работ в строительстве, больших возможностей интеграции с другими участниками проекта. ГГГНТУ им. акад. М. Д. Миллионщикова ведет активную работу по внедрению в учебный процесс программных продуктов Archicad, Autodesk 3ds Max, Revit для подготовки специалистов, обладающих навыками работы в данных программах. Применение современных ВIM не только в образовательном процессе, но и на практике дает возможность более тесного ознакомления инструментами данных программ. В данной статье рассмотрены возможности применения ВIM в ходе реконструкции холла первого этажа второго учебного корпуса Университета, позволившие выявить наиболее оптимальные методы проектирования в целях повышения качества производства работ.

Modern design cannot be imagined without modern application programs designed for the efficiency of construction production. BIM technologies in the construction industry are attracting more and more users due to their versatility, the ability to adapt to any type of design work in construction, and great opportunities for integration with other project participants.GSTOU them. acad. M. D. Millionshchikova is actively working on introducing Archicad, Autodesk 3ds Max, Revit software products into the educational process to train specialists with the skills to work in these programs. The use of modern VIM not only in the educational process, but also in practice makes it possible to better familiarize with the tools of these programs. This article discusses the possibilities of using BIM during the reconstruction of the hall of the first floor of the second academic building of the University, which made it possible to identify the most optimal design methods in order to improve the quality of work.
The investigation of low melt fl ow index polyetheretherketone crystallization kinetics in isothermal mode
Authors: Solovyev A. A. , Lyashenko E. Yu. , Komolov M. B. , Yakovleva K. A.
Published: January 2022

The crystallization kinetics of low melt fl ow index polyetheretherketone has been investigated. The purpose of the work was obtaining the parameters of the crystallization kinetics, which allow infl uencing the properties of the products obtained during the processing of polyetheretherketone into thick-walled products.

The considered material was PEEK-5G grade polyetheretherketone with low melt fl ow index. The study of the process was carried out by the method of diff erential scanning calorimetry in isothermal mode.

The processing of experimental data was performed using Kolmogoff-Avrami equation, the activation energy of the process – using Kissinger one.

The parameters of the process were calculated: the nucleation and growth rates of crystalline structures, the activation energy of the process. The temperature range for the crystallization of polyetheretherketone in the technological process of obtaining thickwalled products has been established.
Pengaruh Non-Performing Loan dan Loan to Deposit Ratio terhadap Cadangan Kerugian Penurunan Nilai
Authors: Vebriana Siti Alawiyah , Setyowati Diharpi Herli , Nurdin Ade Ali
Published: January 2022

The main activity of the bank is to collect and raise funds from third-party channels through credit. In practice, conventional banks are faced with bad debt problems. The Bank's effort to anticipate bad credit is by establishing reserve funds in the form of Loan Loss Provisions (CKPN). The effect of NPL and LDR on CKPN is important to study because it can Maintain good bank performance. The sample size in this study is 36 banks listed on IDX. The data analysis technique used in this study is panel data regression analysis technique followed by classical hypothesis testing. The results of this study show that NPL have a positive impact on CKPN. The regression test results show that LDR has a negative impact on CKPN. The results of NPL and LDR using F test were positive and significant for CKPN.
Aplicación de vendaje neuromuscular como tratamiento coadyuvante en la epicondilitis medial en femenina de 32 años edad softbolista para su reintegración a la práctica de juego
Authors: Cortés-Márquez Sandra Kristal , Pacheco-Sánchez Carla Itzel , Subervier-Ortiz Laura
Published: January 2022

The Medial epicondylitis is one of the most common and disabling injuries of pitchers, it has been shown that proper diagnosis and early treatment of this condition can prevent future defections of pitchers. A causal-experimental, descriptive, longitudinal study of a 32-year-old softball pitcher diagnosed with medial epicondylitis. In this study, the pitcher was reintegrated into the pitch without experiencing painful episodes during and at the end of the game, which is why the physiotherapeutic treatment was complemented with the neuromuscular bandage that supported the forced valgus movement during the pitching. Without showing painful episodes. There was a considerable increase in the range of mobility and the increase in speed in their throws. It could be concluded that the successful treatment can not only reinstate the pitchers to the field of play but also improve their speed and throwing technique by not perceiving painful sensations
Assessing the Effectiveness of Health Preparedness Capacity Building Intervention in Empowering the Urban Poor Community in Rodriguez, Rizal, Philippines
Authors: Mallillin III Marlon Cadauan , Santos-Regal Mary Agnes
Published: January 2022

This study deals with the public health effects of a natural disaster and some public health principles that can be applied to disaster risk reduction and management, focusing on earthquake preparedness for Barangay San Jose - Rodriguez, Rizal, Philippines. The study showed that the urban poor community has a weak history of engagement, and it explores whether facilitated community interventions can empower and develop community preparedness. It followed a participatory approach involving community leaders and members. The study indicated that enhancing and modifying interventions that match community needs will develop community preparedness in the community, potentially increasing the chances of surviving an earthquake and minimizing its deleterious and damaging impact. Community preparedness will require continuous involvement and a cooperative approach to working with communities to support equal and harmonized development.
Conceptualización del envejecimiento en España: un diagnóstico desde la semiótica cognitiva
Authors: Silvera-Roig Marta
Published: January 2022

A partir de una selección de titulares de prensa y presentaciones digitales de planes de pensiones de las entidades bancarias españolas que más invierten en publicidad, este artículo examina nuestra conceptualización del envejecimiento a través de los esquemas-imagen y la teoría de la metáfora conceptual. Mediante las herramientas analíticas de la semiótica cognitiva, este artículo identifica y explora el andamiaje estructural conceptual de los dominios meta envejecimiento y jubilación como estructurandos de emociones primarias y secundarias en una narrativa del malestar.
High-resolution two-dimensional solid-state beam scanner module based on vertical-cavity-surface-emitting laser array
Authors: Li Ruixiao , Hu Shanting , Gu Xiaodong , Koyama Fumio
Published: January 2022

We realized electrical 2D beam scanning with a field of view of 64° × 14° and resolution points number of >9000 (450 × 20) by fabricating a linear array of beam scanners integrated with an electro-thermally tunable surface-grating vertical-cavity surface-emitting laser and assisting with a cylindrical lens. It is expected to cover the field of view of 108° × 40° with resolution points number of >49 000 (780 × 64) by enlarging the full diffraction angle of the diffractive optical element and integrating more scanners in the array. The total module size could be managed in 1 cm scale thanks to the omission of external light sources and simply stacked optics.