bluuebunny/crossref_metadata_2025 huggingface dataset:
The Interaction of Homozygote 192-bp I nsulin-like growth factor-1 ( IGF-1) Polymorphisms and C igarette Smoking to End -stage renal disease ( ESRD)
Authors: Hidayati Titiek , Akrom Akrom , Chang Chih Chih
Published: January 2021

Objective: Smoking and end-stage renal disease (ESRD) are the leading public health problems in Indonesia. Smoking is a known risk factor for the development and progression of ESRD. Specific genetic polymorphisms may modify the harmful effects of cigarette smoking and may also change the inherited risk. IGF-1 CA repeat polymorphism is thought to be associated with an increased incidence of chronic kidney disease in smokers. We investigated the impact of smoking interactions with IGF-1 CA repeat polymorphism with the rate of chronic kidney disease in Yogyakarta Special Region Indonesia. (YSRI) Result: Our study found that smoking and IGF-1 genotype 192 bp are risk factors for ESRD in Indonesia. The combination of genotype 192 bp and smoking is associated with increased ESRD events. Respondents with smoking habits and 192 bp homozygous genotype are at high risk of ESRD. Smoking habit and homozygous 192 bp genotype are strongly interaction.. There was a mild interaction between respondents with smoking habits and heterozygous 192 bp and 188 bp. There was no interaction between non-smokers with heterozygous 192 bp and 188 bp of the IGF-1 gene.
F-18 Fluorodeoxyglucose PET/CT as a Diagnostic Tool in Orbital Inflammatory Disorders
Authors: Elourimi Ghassan , Soussan Michael , Groh Matthieu , Martin Antoine , Héran Françoise , Galatoire Olivier , Dhote Robin , Vicaut Eric , Abad Sébastien
Published: January 2021

Background: In the last decade, FDG-PET/CT has become routine practice in the management of lymphoma or autoimmune diseases. In the current study, we aimed to assess the usefulness of FDG-PET/CT as a potential diagnostic tool for detecting underlying systemic diseases (SD) in patients with orbital inflammatory disorders (OID).Methods: All consecutive patients managed for new-onset OID between 2011 and 2018 in a tertiary referral center for OID, who underwent FDG-PET/CT as part as the etiological diagnostic workup were enrolled. PET-FDG/CT scans were reviewed blindly and were considered as positive for SD detection if they showed lymphadenopathy and/or other visceral lesions with an uptake above blood pool background. We used the standard diagnostic workup (performed in all patients at presentation) as relevant comparator. To quantify the incremental value of FDG-PET/CT over the standard diagnostic workup, the Net Reclassification Index (NRI) and Integrated Discrimination Index (IDI) were used. The final diagnosis was based on international criteria for autoimmune diseases, or histological confirmation for lymphoma, xanthogranuloma, crystal storing histiocytosis (CSH), or idiopathic orbital inflammation syndrome (IOIS). Results: Among the 22 patients enrolled, 14 (63%) had underlying SD (granulomatosis with polyangiitis (GPA), n=1; IgG4-related disease (IgG4-RD), n=5; CSH, n=1; adult onset asthma and periocular xanthogranuloma (AAPOX), n=3; lymphoma, n=4) while the remaining 8 (37%) patients were diagnosed with IOIS. Eleven (50%) patients had a positive FDG-PET/CT. After clinicobiological evaluation, FDG-PET/CT correctly reclassified 29% of patients with SD (p=0.04) and 13% with IOIS (p=0.3), corresponding to an elevated NRI of 0.41±0.17 (p=0.03). The IDI test used to evaluate the improvement of FDG-PET/CT for SD detection was 0.38±0.08 (p<0.001). After FDG-PET/CT, probability changes for SD and IOIS were measured at 0.14 and -0.24, respectively (relative gain of 3.04 for IDI). FDG-PET/CT successfully detected asymptomatic lesions in all patients with a final diagnosis of lymphoma. Conclusion: FDG-PET/CT enabled accurate reclassification of more than one quarter of patients with SD, suggesting its potential value for detecting SD (especially extraorbital lymphoma).
Efficacy of Quetiapine for Delirium Prevention in Hospitalized Older Medical Patients: a Randomized Double-blind Controlled Trial
Authors: Thanapluetiwong Saran , Ruangritchankul Sirasa , Sriwanno Orapitchaya , Chansirikarnjana Sirintorn , Ittasakul Pichai , Ngamkala Tipanetr , Sukumalin Lalita , Charernwat Piangporn , Saranburut Krittika , Assavapokee Taweevat
Published: January 2021

Background: Delirium is a common disorder among hospitalized older patients and results in increased morbidity and mortality. The prevention of delirium is still challenging in older patient care. The role of antipsychotics in delirium prevention has been limited. Therefore, we conducted a trial to investigate the efficacy of quetiapine use to prevent delirium in hospitalized older medical patients.Methods: This study was a randomized double-blind controlled trial conducted at Ramathibodi Hospital, Bangkok, Thailand. Patients aged ≥ 65 years hospitalized in the internal medicine service were randomized to quetiapine 12.5 mg or placebo once daily at bedtime for a maximum 7-day duration. The primary end point was delirium incidence. Secondary end points were delirium duration, length of hospital stay, ICU admission, rehospitalization and mortality within 30 and 90 days.Results: A total of 122 patients were enrolled in the study. Eight (6.6%) left the trial before receiving the first dose of the intervention, whereas 114 (93.4%) were included in an intention-to-treat analysis allocated to the quetiapine or placebo group (n=57 each). The delirium incidence rates in the quetiapine and placebo groups were 14.0% and 8.8% (OR=1.698, 95% CI 0.520-5.545, P=0.381), respectively. Other endpoints in the quetiapine and placebo groups were the median length of hospital stay, 6 (4-8) days versus 5 (4-8) days (P=0.133), respectively; delirium duration, 4 (2.3-6.5) versus 3 (1.5-4.0) days (P=0.557), respectively; ICU admission, 3 (5.3%) patients from both groups (P=1.000); and mortality in the quetiapine and placebo groups, 1 (1.8%) versus 2 (3.5%) at 30 days (P=0.566) and 7 (12.3%) versus 9 (15.8%) days at 90 days (P=0.591). There were no significant differences in other outcomes. None of the participants reported adverse events.Conclusions: Quetiapine prophylaxis did not reduce delirium incidence in hospitalized older medical patients. The use of quetiapine to prevent delirium in this population group should not be recommended.Trial registration: This trial was retrospectively registered with the Thai clinical trials registry (TCTR) at clinicaltrials.in.th (TCTR20190927001) on September 26, 2019.
Hemodynamic Analysis for Endovascular Treatment in Small Unruptured Intracranial Aneurysms: A Matched Comparison Study of Flow Diverter Versus LVIS
Authors: Liu Jian , Li Wenqiang , Zhang Yisen , Wang Kun , Yang Xinjian , Zhang Ying
Published: January 2021

BackgroundWe compared the treatment of small unruptured intracranial aneurysms (UIAs) with flow diverter and LVIS assisted coiling to determine the effects of hemodynamic changes caused by different stent and coil packing in endovascular treatment.MethodsFifty-one UIAs in 51 patients treated with pipeline embolization device (PED) were included in this study, and defined as the PED group. We matched controls 1:1 and enrolled 51 UIAs who treated with LVIS stent, which defined as the LVIS group. Computational fluid dynamics were performed to assess hemodynamic alterations between PED and LVIS. Clinical analysis was also performed between these two groups after the match.ResultsThere was no difference in procedural complications between two groups (P=0.558). At the first angiographic follow-up, the complete occlusion rate was significantly higher in the LVIS group compared with that in the PED group (98.0% vs 82.4%, P = 0.027). However, during the further angiographic follow-up, the complete occlusion rate in PED group achieved 100%, which was higher than that in LVIS group (98.0%). Compared with the LVIS group after treatment, cases in PED group showed a higher value of velocity in the aneurysm (0.03 ± 0.09 vs 0.01 ± 0.01, P=0.037) and WSS on the aneurysm (2.32 ± 5.40 vs 0.33 ± 0.47, P=0.011). Consequently, the reduction ratios of these two parameters were also showed statistical differences. These parameters in LVIS group showed much higher reduction ratios. However, the reduction ratio of the velocity on the neck plane was comparable between two groups. ConclusionsBoth LVIS and PED were safe and effective for the treatment of small UIAs. However, LVIS-assisted coiling produced greater hemodynamic alterations in the aneurysm sac compared with PED. The hemodynamics in the aneurysm neck may be a key factor for aneurysm outcome.
Biomechanical Study of Tile C3 Pelvic Fracture Fixation Using an Anterior Internal System Combined With Sacroiliac Screws
Authors: liu lin , Zeng Donggui , Fan Shicai , Peng Yongxing , Song Hui , Jin Dadi , Zeng Letian
Published: January 2021

BackgroundThis study aimed to investigate the effectiveness of different methods of fixation of Tile C3 pelvic fractures. We applied minimally-invasive treatment using an anterior internal fixator combined with sacroiliac screws. ObjectivesTo compare the biomechanical properties of different fixation models in pelvic facture specimens, using an internal fixation system or a steel plate combined with sacroiliac screws. MethodsSixteen fresh adult cadaver pelvic specimens were randomly separated into four groups named A, B, C and D. The four groups were respectively stabilized using a two-screwed, three-screwed, or four-screwed anterior internal fixator or a steel plate with sacroiliac screws. All models were tested in both standing and sitting positions. Vertical loads of 600 N were applied increasingly. Shifts of bilateral sacroiliac joints and pubis rupture were measured. ResultsThe shifts in sacroiliac joints and pubis rupture in the standing position were all less than 3.5 mm and the shifts in the sitting position were all less than 1 mm. In the standing position, the results of shifts in the sacroiliac joints were: Group C < Group D < Group B < Group A. For comparisons between A:B and C:D, P > 0.05. For comparisons between A, B:C, D, P < 0.05. The results of shifts in pubis ruptures were: Group D < Group C < Group B < Group A. In the comparison between C:D, P > 0.05, for comparisons between A:B, A:C, A:D, B:C, and B:D, P < 0.05. In the sitting posture, the results of shifts in the sacroiliac joints were: Group C < Group D < Group B < Group A, the shifts in the pubis ruptures were: Group D < Group C < Group B < Group A. For comparison between C:D, P > 0.05. For comparisons between A:B, A:C, A:D, B:C, and B:D, P < 0.05. ConclusionUse of an anterior internal fixator combined with sacroiliac screws effectively stabilized Tile C3 pelvic fractures. Among the options tested, a two-screwed internal fixator combined with sacroiliac screws was easier to operate. The stability of specimens increased as the number of screws in the internal fixator increased.
Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice
Authors: Sun Shihui , He Lei , Zhao Zhongpeng , Gu Hongjing , Fang Xin , Wang Tiecheng , Yang Xiaolan , Chen Shaolong , Deng Yongqiang , Li Jiangfan , Zhao Jian , Li Liang , Li Xinwang , He Peng , Li Ge , Li Hao , Zhao Yuee , Gao Chunrun , Lang Xiaoling , Wang Xin , Fei Guoqiang , Li Yan , Geng Shusheng , Gao Yuwei , Wei Wenjin , Hu Zhongyu , Han Gencheng , Sun Yansong
Published: January 2021

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to infect people globally. The increased COVID-19 cases and no licensed vaccines highlight the need to develop safe and effective vaccines against SARS-CoV-2 infection. Multiple vaccines candidates are under pre-clinical or clinical trails with different strengths and weaknesses. Here we developed a pilot scale production of a recombinant subunit vaccine (RBD-Fc Vacc) with the Receptor Binding Domain of SARS-CoV-2 S protein fused with the Fc domain of human IgG1. RBD-Fc Vacc induced SARS-CoV-2 specific neutralizing antibodies in non-human primates and mice, and the antibodies induced in macaca fascicularis neutralized three divergent SARS-CoV2 strains, supporting broader neutralizing ability. Three times immunizations protected Macaca fascicularis (20ug or 40ug per dose) and mice (10ug or 20ug per dose) from SARS-CoV-2 infection respectively, including the protection against SARS-CoV-2 adapted virus MASCp6 which contains N501Y mutation, a key residue increasing binding affinity to human and murine ACE2. These data support clinical development of SARS-CoV-2 vaccines and provide a promising strategy to prevent different stains of SARS-CoV-2 infection. RBD-Fc Vacc is currently being assessed in randomized controlled phase 1/II human clinical trails
The Circulating Levels of CTRP1 and CTRP5 Are Associated with Obesity Indices and Carotid Intima-Media Thickness (cIMT) Value in Patients with Type 2 Diabetes: A Preliminary Study
Authors: Majidi Ziba , Emamgholipour Solaleh , Omidifar Abolfazl , Fard Soheil Rahmani , Poustchi Hossein , Shanaki Mehrnoosh
Published: January 2021

Background: There is growing evidence that the C1qTNF-related protein (CTRP) family has a crucial role in the physiology and pathophysiology of metabolic disorders such as Type 2 Diabetes (T2D) and obesity. We sought to identify the association of CTRP1 and CTRP5 circulating levels with various obesity parameters such as visceral adipose tissue (VAT) thickness, visceral adiposity index (VAI), and with carotid intima-media thickness (cIMT) in patients with T2D and healthy subjects. Methods: This preliminary study consisted of men with T2D (n=42) and men without T2D (n=42). cIMT and VAT thickness measurement was performed using an Accuvix XQ ultrasound. Circulating levels of CTRP1, CTRP5, and adiponectin were measured by enzyme-linked immunosorbent assay (ELISA).Results: CTRP-1 and CTRP1/CTRP5 ratio was markedly higher in patients with T2D compared to controls (p < 0001 and p = 0004 respectively). Interestingly, binominal logistic regression revealed that a higher circulating level of CTRP1 was associated with the presence of T2D (odds ratio [OR]: 1.009 [95% CI: 1.004-1.015]; P=.001). CTRP1 circulating levels were correlated with WHR, VAT, and HOMA-IR in the whole population study. Also, we observed that the ratio of CTRP1 to CTRP5 in plasma (β = 0.648, P=0.005) and CTRP5 circulating levels (β = 0.444, P=0.049) are independently associated with cIMT value.Conclusions: Our results indicated that CTRP1 and CTRP5 concentrations were correlated with atherosclerosis in men with T2D and these adipokines might have a causal role for cardiometabolic risk in T2D.However, more studies in large sample sizes are required to clarify the role of CTRPs in T2D pathogenesis.
Effects of active gases on droplet transfer and weld morphology in pulsed-current NG-GMAW of mild steel
Authors: Liu Guoqiang , Tang Xinhua , Xu Qi , Lu Fenggui , Cui Haichao
Published: January 2021

The current research of narrow-gap gas metal arc welding (NG-GMAW) primarily focuses on improving the sidewall fusion and avoiding the lack-of-fusion defect. However, the high cost and operation difficulty of the methods limit the industrial application. In this study, small amount of active gases CO2 and O2 were added into pure argon inert shielding gas to improve the weld formation of pulsed-current narrow-gap gas metal arc welding (NG-GMAW) of mild steel. Their effects on droplet transfer and arc behavior were investigated. A high-speed visual sensing system was utilized to observe the metal transfer process and arc morphology. When the proportion of CO2, being added into the pure argon shielding gas, changes from 5% to 25%, the metal transfer mode changes from pulsed spray streaming transfer to pulsed projected spray transfer, while it remains the pulsed spray streaming transfer when 2% to 10% O2 is added. Both CO2 and O2 are favorable to stabilizing arc and welding process. O2 is even more effective than CO2. However, O2 is more likely to cause slags on the weld surface, while CO2 can improve the weld appearance in some sense. The weld surface concavity in NG-GMAW is greatly influenced by the addition of active gas, but the weld width and weld penetration almost keep constant. This study proposes a new method which is beneficial to improving the weld bead formation and welding process stability.
Measuring PrEP Preferences Among U.S. Military Men Who Have Sex with Men: Results of an Adaptive Choice Based Conjoint Analysis Study
Authors: Gutierrez Jose I , Dubov Alex , Altice Frederick , Vlahov David
Published: January 2021

Background Pre-exposure prophylaxis (PrEP) effectively prevents HIV infection, yet its uptake remains low among U.S. military men who have sex with men (MSM). Research shows that health services matching preferences produce favorable outcomes. Therefore, an early step for planning program design is to characterize and identify preferences for improved PrEP delivery within this population. Methods HIV-negative military MSM were recruited through a closed, LGBT military social media group. Participants completed an anonymous survey presenting five experimentally varied attributes of interest related to PrEP administration (dosing method, provider type, visit location, lab work evaluation location, and dispensing venue). Relative importance and part-worth utility scores were generated using Hierarchical Bayes (HB) estimation, and the randomized first choice model was used to examine participation interest across eight possible PrEP program scenarios.Results Among the 429 participants and the eight scenarios that varied the five attributes into delivery profiles, the most preferred scenarios featured a daily tablet, PrEP injection, or PrEP implant, along with a military provider, smartphone/telehealth visit, and on-base locations for lab evaluation and medication pick-up. Responses emphasized the importance for providers to be familiar with PrEP prescription knowledge, and to provide interactions sensitive to sexual identity and mental health.Conclusion These results suggest that a daily tablet PrEP program within a military healthcare setting is preferred over a civilian or off-site one, yet more importantly, it points to a high value placed on the quality of clinical interactions. High interest in long-acting implants and injections also suggest potential markets for future PrEP engagement.
Findings and Feasibility of Major Salivary Gland Ultrasound in Childhood-Onset Systemic Lupus Erythematosus: A Pilot Study
Authors: McDonald Joseph , Vega-Fernandez Patricia , Ting Tracy
Published: January 2021

Background: Childhood-onset systemic lupus erythematosus (cSLE) is a complex autoimmune disorder with multi-organ manifestations and can be associated with other rheumatic diseases including Sjögren’s syndrome (SS). Salivary gland ultrasound (SGUS) represents a noninvasive tool to screen for salivary gland disease in rheumatic disease patients. The aims of this cross-sectional study were to determine feasibility of major SGUS in a clinic setting and to identify characteristics in a cohort of cSLE patients (without confirmed SS) that may be associated with salivary gland abnormalities consistent with secondary SS.Methods: Patients with SLE onset prior to age 18 were recruited. Patients completed questionnaires rating symptoms and underwent major SGUS examination. Disease and demographic differences were compared between cSLE patients with abnormal SGUS vs. cSLE patients with normal SGUS using t-tests and Fisher’s exact tests.Results: 31 cSLE patients were recruited, 84% were female, 55% were Caucasian. The average disease duration among all patients was 5 years. Average time to complete the SGUS examination and scoring protocol was 7 minutes. 35% of SGUS scores were abnormal and significantly associated with IgG level at diagnosis, and anti-Ro and anti-La antibodies.Conclusions: This is one of the first studies to our knowledge that assesses major SGUS in a cohort of patients with cSLE without prior diagnoses of SS. The SGUS protocol was feasible to perform by rheumatologists in a clinic setting. Although the sample size was small, SGUS abnormalities were identified in one-third of patients. IgG level at diagnosis and anti-Ro and anti-La antibodies may be associated with SGUS abnormalities.
Die berufliche Tabletaneignung von Lehrkräften als Beispiel der Mediatisierung pädagogischer Handlungskontexte
Authors: Gerhardts Lara , Dehmel Lukas , Meister Dorothee M.
Published: January 2021

Die Digitalisierung von Schule und Unterricht weiter voranzubringen, gehört zu den erklärten Zielen der Bildungspolitik. Dementsprechend werden inzwischen immer mehr Digitalisierungsprojekte gefördert, wobei die schulische Ausstattung mit Tablets bereits seit einigen Jahren und nach wie vor einen Schwerpunkt bildet. Im Rahmen dieses Beitrags gehen wir anhand von qualitativen Analysen empirischen Datenmaterials aus unserer Begleitforschung zu einer städtischen Ausstattungsinitiative der Frage nach, wie die berufliche Aneignung von Diensttablets durch Lehrkräfte – als einem elementaren Bestandteil der tiefgreifenden Mediatisierung des schulischen Arbeitsalltags – im Einzelnen abläuft und welche Einflussfaktoren dabei eine Rolle spielen. Mit Rekurs auf die Theorie einer «Pädagogik der Dinge» (Nohl 2011) interpretieren wir den Aneignungsprozess als Ausbildung eines «Hybrid-Akteurs» (ebd., 101) aus Lehrkraft und mobilem Endgerät. Bedingt durch technische Weiterentwicklungen fordert das Tablet die Medienkompetenz der Lehrkraft im Rahmen ihres beruflichen Handelns immer wieder neu heraus, sodass sich ein fortwährender Wechsel zwischen Phasen der Handlungssicherheit und Phasen der Irritation ergibt. Wie schnell und wie gut eine Lehrkraft technikinduzierte Irritationen überwinden und sich an neue mediale Gegebenheiten anpassen kann, hängt von verschiedenen Faktoren ab. Als besonders aneignungsrelevant konnten wir basierend auf unseren empirischen Daten erstens die allgemeine Grundhaltung zum schulischen Einsatz digitaler Medien identifizieren; zweitens die bereits vorhandene Medienkompetenz der Lehrkraft bzw. ihre diesbezügliche Selbsteinschätzung; und drittens die Unterstützung, die der Lehrkraft während des Aneignungsprozesses zuteil wird. Im Sinne einer möglichst effizienten Integration des Tablets in das gesamte berufliche Handlungsspektrum von Lehrkräften lassen sich hinsichtlich aller drei genannten Einflussfaktoren gewisse Optimierungspotenziale aufzeigen.
Effect of Planting Density on the Yield and Growth of Intercropped Tomatoes and Peppers in Florida
Authors: Sandhu Ravneet K. , Boyd Nathan S. , Zotarelli Lincoln , Agehara Shinsuke , Peres Natalia
Published: January 2021

Florida vegetable growers are facing high production costs due to high input costs, lower profitability, and competition from foreign markets. Multi/intercropping allows growers to increase the yields and profits per unit area by producing multiple crops on the same beds. Experiments determining the effects of intercropping and plant spacing was conducted in Fall 2018 and 2019 at Gulf Coast Research and Education Center, Balm. Tomato and bell pepper were intercropped at low and high planting density on plastic-covered beds. Bell pepper shoot biomass was significantly (P < 0.001) reduced when intercropped with tomato, compared with monocropped bell pepper. However, tomato shoot biomass was significantly reduced when tomato plant density increased, but it was unaffected by bell pepper intercropping. Biomass of both crops was unaffected by relay cropping. Bell pepper yields when intercropped with tomato at low density (60 cm tomato-tomato and 38 cm pepper-pepper) had similar yields to bell pepper planted alone in low and high planting density. We concluded that bell pepper plants were more sensitive to interspecific competition, whereas tomato plants were more sensitive to intraspecific competition. Intercropping may be a viable option for growers at recommended plant densities used for monocrops. However, high plant density is not recommended.
Assessment of the radiation situation and distribution of radionuclides in the air of the uranium protoxide-oxide calcination shop
Authors:   1Navoi Mining and Metallurgical Factory, Muzafarov Amrullo M. , Kulmatov Rashid A. ,   National University of Uzbekistan, Allaberganova Gulchekhra M. ,   Navoi State Mining Institute
Published: January 2021

The exposure dose rates, the equivalent equilibrium volume activity of radon, and the activity of long-lived alpha-nuclides in the air of the uranium protoxide-oxide calcination shop were determined. Annual effective doses for workers were calculated. Through the use of nuclear-based polietilentereftalata and chemical filters, the disperse composition of particles in the air was studied. The effectiveness of filters in sampling was evaluated for the uranium content. The kinetics of distribution of uranium in various fractions was studied. The quality coefficients of filters that accumulate uranium relative to its norm in various working places of the shop were estimated.
Assessment of the psycho-emotional risks of office workers
Authors:   Irkutsk National Research Technical University, Shevchenko Elena I. , Svetlolobova Mariya A. ,   Irkutsk National Research Technical University
Published: January 2021

With increasing digitalization of the economy and implementation of Industry 4.0 technologies, the number of office workers is increasing. Accordingly, the structure of occupational risks can change. Psycho-emotional risks will play a dominant role in the list of harmful production factors. The aim of the work is to assess the psychoemotional risks of office workers using a survey method. The study identified a high level of psycho-emotional risks and stress among the participants. This has a direct impact on the labor productivity and physical health of workers. According to the studies, the psychological climate in the team, which is an important component of productive work affecting the psychophysiological state of workers is contradictory, which reduces the levels of motivation and labor productivity. The study allowed us to identify the main reasons of psychoemotional risks: working conditions, lack of special places for rest, the poor work organization,workload, poor quality workload distribution management, n lack of interest. The company's management needs to solve these problems, since the efficiency of the company depends on the well-being of employees.
A PRE-TEST LOGO AND ADVERTISING “MARI KEMBALI KE DESA” SOCIAL CAMPAIGN TO MOTIVATE FIRST JOBBERS WANDERERS IN JAKARTA
Authors: Abhidana Vashti Trisawati , Kana Novi Dila
Published: January 2021

Urbanization in Indonesia brings a complex problem in the cities. People from the rural area perceive big city will bring more prosperity than living in their village. However, some young adults who lived in the urban area because of their work, think about to groom and grow their own village to make the community alive and make some changes. Therefore, through the social campaign “Ayo Kembali Ke Desa” created by one of the graphic design new media students (GDNM), is motivating young adults to go back to the village. In this paper is conducting a pretest for campaign logo and promotional materials that has been created, because in social campaign conducting a pre-test test is a mandatory before launching the campaign. To test the logo and advertisement materials, the researchers use the approach of Seven Steps Paul Rand Logo test and Ten Elements of Advertisement Test. Through qualitative research with focus group discussion, the campaign has good prospect gain the interest of the target audience with several adjustments, especially in logo and series of print advertisements; however, for TV commercial the visual needs more emotional approach scenes.
CHINESE GRAMMAR AUTO-CORRECT WEBSITE CHINESEGRAMMARCHECKER.COM DEVELOPMENT MODEL
Authors: Wangi Julita , Rosalin Kelly , Theresia Theresia
Published: January 2021

In the process of learning and using Chinese, Indonesia students may have grammatical errors due to negative migration of their native language. At present, there is no Mandarin grammar correction website or application that can answer the needs of Mandarin learners. Therefore, researchers want to try to provide a website chinesegrammarchecker.com that can answer the needs of Chinese language learners in Indonesia so as to facilitate Chinese language learners in mastering Chinese grammar. Hope researchers are learners can learn independently in making sentences in Chinese using proper and correct Chinese grammar. The method used in this study is a qualitative approach. The researcher will collect basic level Chinese grammar patterns in the textbooks used in the Chinese Language I courses, namely Er Ya Basic Chinese: Comprehensive Course (I) and Basic Chinese: Comprehensive Course (II). Then from these patterns user can check their sentences on this website. After the website chinesegrammarchecker.com was completed, then it was tested for several users to see the advantages and disadvantages of this website chinesegrammarchecker.com.
Optimizing Access to Financial Capital of Creative Economy for Startups Towards Global Competitiveness
Authors: Santoso Sugeng
Published: January 2021

The lack of understanding of the financial capital of the creative economy regarding non-bank financial institutions limits the growth of Indonesia’s creative economy. Strategies through policies, capital owners, creative economy players and bring together capital owners with players. The capital of the creative economy is represented on the criteria: entrepreneurial characteristics, product/service characteristics, market characteristics, and financial characteristics. The method used is a qualitative analysis and quantitative analysis which starts from data collection, data analysis, participatory discussion, drawing conclusions, formulating policies and stakeholder synergy. The startup mentoring scoring instrument is a framework for investor’s decision making to invest in the startup. 3 scoring elements of mentoring startup scoring: Product & key person with a weight of 55%, Traction with a weight of 25%, and Investment with a weight of 20%. Primary data were obtained by participatory observation, field studies, and key informant interviews through startup mentoring programs, workshops, and startup competitions. Results: Among 20% of startups pitched in front of investors,  there are 11% of startups that investors interested in and got funding from a consortium of Indonesian and foreign venture capital companies. Matchmaking activities increase added value, and the implemented policy also increases added value.
Investigation for synchronization characteristics of double cam vibrating screen
Authors: Hou Yongjun , Zou Rui , Fang Pan , Liu Youping , Peng Hong , He Yinkai
Published: January 2021

Aiming at the shortcomings of traditional vibrating screens with large vibration mass, a double eccentric cam self-synchronous vibrating screen is proposed. The motion differential equation of the vibrating screen system is derived by using Lagrange equation and the steady state solution is obtained. According to Hamilton principle, the synchronization condition of the vibration system is deduced, and the stability condition of the self-synchronization motion is obtained. The influencing factors of synchronization and stability are investigated by using numerical calculation and simulation analysis methods. The results show that stable self-synchronous motion of the vibration system is implemented when the synchronization and stability conditions are satisfied; the value of the stable phase difference of two cams varies in the range of (–1.5 rad, 0), and compared with the residual torque difference, the eccentricity of eccentric cams has a greater impact on the stable phase difference; additionally, a linear motion track of the vibrating screen is achieved.
Virtual Reality Relaxation for Patients With a Psychiatric Disorder: Crossover Randomized Controlled Trial
Authors: Veling Wim , Lestestuiver Bart , Jongma Marieke , Hoenders H J Rogier , van Driel Catheleine
Published: January 2021

Background

Virtual reality (VR) relaxation is a promising mental health intervention that may be an effective tool for stress reduction but has hardly been tested in clinical trials with psychiatric patients. We developed an easy-to-use VR self-management relaxation tool (VRelax) with immersive 360° nature videos and interactive animated elements.

Objective

To investigate the immediate effects of VR relaxation on negative and positive affective states and short-term effects on perceived stress and symptoms in patients with a psychiatric disorder, compared to standard relaxation exercises.

Methods

A randomized crossover trial was conducted in 50 patients receiving ambulatory treatment for anxiety, psychotic, depressive, or bipolar disorder. Participants were randomly assigned to start with VRelax or standard relaxation and used both interventions for 10 days at home. They completed 8 visual analog scales of momentary negative and positive affective states before and after each session. Global perceived stress and psychiatric symptoms were measured before and after both intervention periods. Treatment effects were analyzed with multilevel mixed model regression analyses and 2-way analysis of variance.

Results

Both VRelax and standard relaxation exercises led to a statistically significant immediate improvement of all negative and positive affective states. Compared to standard relaxation, VRelax resulted in a significantly greater reduction of total negative affective state (change 16.2% versus 21.2%; t1684=−2.02, 95% CI −18.70 to −0.28; P=.04). Specifically, VRelax had a stronger beneficial effect on momentary anxiety (t1684=−3.24, 95% CI −6.86 to −1.69), sadness (t1684=−2.32, 95% CI −6.51 to −0.55), and cheerfulness (t1684=2.35, 95% CI 0.51 to 5.75). There were no significant differences between short-term effects of the two treatments on global perceived stress and symptoms.

Conclusions

If the results of this trial are replicated and extended, VRelax may provide a much-needed, effective, easy-to-use self-management relaxation intervention to enhance psychiatric treatments.

Trial Registration

Netherlands Trial Register NTR7294; https://www.trialregister.nl/trial/7096
Assessing Children’s Fine Motor Skills With Sensor-Augmented Toys: Machine Learning Approach
Authors: Brons Annette , de Schipper Antoine , Mironcika Svetlana , Toussaint Huub , Schouten Ben , Bakkes Sander , Kröse Ben
Published: January 2021

Background

Approximately 5%-10% of elementary school children show delayed development of fine motor skills. To address these problems, detection is required. Current assessment tools are time-consuming, require a trained supervisor, and are not motivating for children. Sensor-augmented toys and machine learning have been presented as possible solutions to address this problem.

Objective

This study examines whether sensor-augmented toys can be used to assess children’s fine motor skills. The objectives were to (1) predict the outcome of the fine motor skill part of the Movement Assessment Battery for Children Second Edition (fine MABC-2) and (2) study the influence of the classification model, game, type of data, and level of difficulty of the game on the prediction.

Methods

Children in elementary school (n=95, age 7.8 [SD 0.7] years) performed the fine MABC-2 and played 2 games with a sensor-augmented toy called “Futuro Cube.” The game “roadrunner” focused on speed while the game “maze” focused on precision. Each game had several levels of difficulty. While playing, both sensor and game data were collected. Four supervised machine learning classifiers were trained with these data to predict the fine MABC-2 outcome: k-nearest neighbor (KNN), logistic regression (LR), decision tree (DT), and support vector machine (SVM). First, we compared the performances of the games and classifiers. Subsequently, we compared the levels of difficulty and types of data for the classifier and game that performed best on accuracy and F1 score. For all statistical tests, we used α=.05.

Results

The highest achieved mean accuracy (0.76) was achieved with the DT classifier that was trained on both sensor and game data obtained from playing the easiest and the hardest level of the roadrunner game. Significant differences in performance were found in the accuracy scores between data obtained from the roadrunner and maze games (DT, P=.03; KNN, P=.01; LR, P=.02; SVM, P=.04). No significant differences in performance were found in the accuracy scores between the best performing classifier and the other 3 classifiers for both the roadrunner game (DT vs KNN, P=.42; DT vs LR, P=.35; DT vs SVM, P=.08) and the maze game (DT vs KNN, P=.15; DT vs LR, P=.62; DT vs SVM, P=.26). The accuracy of only the best performing level of difficulty (combination of the easiest and hardest level) achieved with the DT classifier trained with sensor and game data obtained from the roadrunner game was significantly better than the combination of the easiest and middle level (P=.046).

Conclusions

The results of our study show that sensor-augmented toys can efficiently predict the fine MABC-2 scores for children in elementary school. Selecting the game type (focusing on speed or precision) and data type (sensor or game data) is more important for determining the performance than selecting the machine learning classifier or level of difficulty.
Toward Using Twitter for Tracking COVID-19: A Natural Language Processing Pipeline and Exploratory Data Set
Authors: Klein Ari Z , Magge Arjun , O'Connor Karen , Flores Amaro Jesus Ivan , Weissenbacher Davy , Gonzalez Hernandez Graciela
Published: January 2021

Background

In the United States, the rapidly evolving COVID-19 outbreak, the shortage of available testing, and the delay of test results present challenges for actively monitoring its spread based on testing alone.

Objective

The objective of this study was to develop, evaluate, and deploy an automatic natural language processing pipeline to collect user-generated Twitter data as a complementary resource for identifying potential cases of COVID-19 in the United States that are not based on testing and, thus, may not have been reported to the Centers for Disease Control and Prevention.

Methods

Beginning January 23, 2020, we collected English tweets from the Twitter Streaming application programming interface that mention keywords related to COVID-19. We applied handwritten regular expressions to identify tweets indicating that the user potentially has been exposed to COVID-19. We automatically filtered out “reported speech” (eg, quotations, news headlines) from the tweets that matched the regular expressions, and two annotators annotated a random sample of 8976 tweets that are geo-tagged or have profile location metadata, distinguishing tweets that self-report potential cases of COVID-19 from those that do not. We used the annotated tweets to train and evaluate deep neural network classifiers based on bidirectional encoder representations from transformers (BERT). Finally, we deployed the automatic pipeline on more than 85 million unlabeled tweets that were continuously collected between March 1 and August 21, 2020.

Results

Interannotator agreement, based on dual annotations for 3644 (41%) of the 8976 tweets, was 0.77 (Cohen κ). A deep neural network classifier, based on a BERT model that was pretrained on tweets related to COVID-19, achieved an F1-score of 0.76 (precision=0.76, recall=0.76) for detecting tweets that self-report potential cases of COVID-19. Upon deploying our automatic pipeline, we identified 13,714 tweets that self-report potential cases of COVID-19 and have US state–level geolocations.

Conclusions

We have made the 13,714 tweets identified in this study, along with each tweet’s time stamp and US state–level geolocation, publicly available to download. This data set presents the opportunity for future work to assess the utility of Twitter data as a complementary resource for tracking the spread of COVID-19.
Trends in Discard of Kidneys from Hepatitis C Viremic Donors in the United States
Authors: Chang Su-Hsin , Merzkani Massini , Lentine Krista L. , Wang Mei , Axelrod David A. , Anwar Siddiq , Schnitzler Mark A. , Wellen Jason , Chapman William C. , Alhamad Tarek
Published: January 2021

Background and objectives

Kidneys from hepatitis C virus (HCV) viremic donors have become more commonly accepted for transplant, especially after effective direct-acting antiviral therapy became available in 2014. We examined the contemporary trend of kidney discard from donors with HCV seropositivity and viremia.

Design, setting, participants, & measurements

Data from the Organ Procurement and Transplantation Network were used to identify deceased donor kidneys recovered for transplant. The exposure was donor HCV antibody status in the first analyses, and donor HCV antibody and viremia status in the second analyses. Multilevel, multivariable logistic regression was used to assess the association of these HCV exposure measures with kidney discard, adjusted for donor characteristics. Multilevel analyses were conducted to account for similar kidney discard pattern within clusters of organ procurement organizations and regions.

Results

Among 225,479 kidneys recovered from 2005 to 2019, 5% were from HCV seropositive donors. Compared with HCV seronegative kidneys, the odds of HCV seropositive kidney discard gradually declined, from a multivariable-adjusted odds ratio (aOR) of 7.06 (95% confidence interval [95% CI], 5.65 to 8.81) in 2014, to 1.20 (95% CI, 1.02 to 1.42) in 2019. Among 82,090 kidneys with nucleic acid amplification test results in 2015–2019, 4% were from HCV viremic donors and 2% were from aviremic seropositive donors. Compared with HCV aviremic seronegative kidneys, the odds of HCV viremic kidney discard decreased from an aOR of 4.89 (95% CI, 4.03 to 5.92) in 2018, to 1.48 (95% CI, 1.22 to 1.81) in 2019. By 2018 and 2019, aviremic seropositive status was not associated with higher odds of discard (2018: aOR, 1.13; 95% CI, 0.88 to 1.45; and 2019: aOR, 0.97; 95% CI, 0.76 to 1.23).

Conclusions

Despite the decrease in kidney discard in recent years, kidneys from viremic (compared with aviremic seronegative) donors still had 48% higher odds of discard in 2019. The potential of these discarded organs to provide successful transplantation should be explored.
Еще раз о Босом волке в тюрко-монгольском эпосе и «Слове о полку Игореве»
Authors:   Kalmyk Scientific Center of the RAS, Burykin Alexey A. ,   Institute for Linguistic Studies of the RAS
Published: January 2021

The article analyses the names of the wolf in the eposes of the Mongolian and Turkic nations, which is of interest for defining the Mongolian and Turkic epic traditions and perceptions related to the wolf. One of the problems discussed by the author is the understanding of the Old Russian word-combination ‘босый волк’(off-white wolf) which appears in “The Song of Igor’s Campaign”. In the Mongolian folklore, a name of the wolf includes the word hалзн ‘a white mark or white stripe on the forehead of the animal’ which is inherent in the definition of a wolf by color. This specification allows us to eliminate all the fancy translations of the word combination ‘босый волк’(off-white wolf) and matches well the notion of the color of the wolf in the real life.
Калмыцкие пословицы и поговорки в записи И. И. Попова
Authors:   Kalmyk Scientific Center of the RAS, Goryaevа Baira B. , Ubushieva Danara V. ,   Kalmyk Scientific Center of the RAS
Published: January 2021

The article gives the description of the manuscript notebook “Proverbs and Sayings of the Don Kalmyks” from the collection of the collector of Kalmyk folklore Ivan Ivanovich Popov, that is kept at the State Archive of Rostov region. I. I. Popov recorded different genres of Kalmyk folklore — fairy tales, riddles, proverbs, ‘true stories’, one song from the heroic Kalmyk epos “Jangar” and some fairy tales. The folklore samples, recorded in 1890–1894, after 125 years have not been described and fully introduced into the science. Proverbs and sayings of Don Kalmyks are one of these underinvestigated genres of the Kalmyk folklore tradition recorded by I. I. Popov. The study gives preliminary description of the samples of this genre. It has been found out that the manuscript is incomplete, some pages are missing. The specific features of recording oral texts by I. I.Popov are: the folklore samples are recorded in the Old-Kalmyk script “clear script” and in Cyrillic alphabet (with the use of additional symbols), the author gives parallel Russian translation and also extensive comments, rating and the records of variations.
Изменяющаяся идентичность современных калмыков (анализ анкетных опросов 2017, 2020 гг. в Калмыкии)
Authors:   Kalmyk Scientific Center of the RAS, Namrueva Ludmila V.
Published: January 2021

Identity is not only the most utilized category in the analysis of the contemporary society, but also a constantly changing characteristic of a personality, a social interaction. The identity reflects the state of the community, the aspects of value systems of an individual or a group which under the conditions of instability undergo constant changes and require assurance and security. That is why the identity is in the focus of researchers from different social sciences (sociology psychology, pedagogy, political studies, cultural studies). The article presents the analysis of the problem of identity based on the results of the surveys conducted in 2017 and 2020 in Kalmykia.
Ballistic tests of double-based propelling charges with different carbon black content
Authors: Motyl Krzysztof , Zygmunt Bogdan , Cholewiak Andrzej , Szczepanik Mirosław
Published: January 2021

Nitrocellulose and nitroglycerin are the main components of double-base propellants comprising up to 95% of their total mass. A chemical stabiliser and a burn rate modifier are required components, added in amounts of several percent. The study analyses the effect of carbon black content, contributing less than 1% of the propellant mass, on the burning rate of differently shaped propelling charges. The experiments, carried out on high energetic, double-base propelling charges, showed that the carbon black content significantly affects the burning rate of the propelling charge in the rocket motor chamber.
Effect of aluminium additives on selected detonation parameters of a bulk emulsion explosive
Authors: Kramarczyk Bartłomiej , Pytlik Mateusz , Mertuszka Piotr
Published: January 2021

The article presents an assessment of the influence of aluminium granules content on selected detonation parameters of a chemically sensitised bulk emulsion explosive. The analysis covered determination of relative explosive strength using a ballistic mortar and Trauzl blocks, free field air blast tests and detonation velocity measurements. Five types of emulsion explosives with differing aluminium content were tested at loadings of 0, 1, 3, 5 and 7%.
Termite pyrotechnic compositions of iron and alkaline earth metals peroxides
Authors: Wojewódka Andrzej , Gerlich Marcin
Published: January 2021

The fallowing article presents the combustion studies of Fe/alkaline earth metals peroxides composition. It contains a literature review and the results of own research, which aim is to determine the possibility of using iron-based thermite compositions in time delay elements. The article focuses on the investigation of combustion front propagation rate as a function of a pressing load, the iron content and the purity of used oxidants. The DSC, TG and XRD analysis confirmed that reactions in this system occurs mainly in the solid state.