bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the relationship between teacher professionality and occupational experience
Authors: Leibur Tiiu , Saks Katrin , Chounta Irene-Angelica
Published: May 2019

Professional development is a key process within the wider agenda of raising standards and increasing societal growth capacity by improving teaching policy and practice in education. The aim of the research was to explore the relations between teacherâ€™s professionality and occupational qualifications. Forty teachers were asked to estimate their pedagogical, core and holistic representation competencies. The correlation analysis was applied to investigate the relations between the length of employment and the competencies. The results indicated positive but weak correlations that suggest the relationship between learning gains and development need as well as between assessment and targeted feedback. A negative but still weak correlation was found between the length of employment and ensuring physical, mental and emotional wellbeing. Future work will focus on elaborating the instrument used in this study as well as the experimental setup in order to gain further insights and reliable results.

Keywords: Professional development, occupational qualification, lifelong learning.
Personality traits in the light of the effectiveness of transformational vocational school leadership and leaders
Authors: Anastasiadou Sofia D
Published: May 2019

The Big Five Personality Traits very well known as five-factor model (FEM), which is a taxonomy for personality traits, has a an effect on Transformational School Leadership and Leaders. Personality traits are the most powerful pylons for raising educational standards and achieving excellence based on the effectual Leadership. Openness to experience, conscientiousness, extraversion, agreeableness and neuroticism constitute the FEM. Transformational School Leadership model that comprises an essential element of quality assurance is based on the constructs of Setting Directions, Developing People, Redesigning the Organisations, Reliability of Administrative Leadership. Measures of Teachersâ€™ Capacities, Measures of Teachersâ€™ Motivation, Measures of Teachersâ€™ Work Setting and Measures of Teachersâ€™ Classroom Practices. To test the research hypotheses, a survey was carried out on 215 Greek secondary education teachers teaching in vocational lyceums, senior high schools in Greece. Moreover, 215 Greek secondary Vocational education teachers evaluate the effect of Personality Traits and characteristics on Transformational Vocational School Leadership and Leaders.

Keywords: Personality traits, leadership, vocational, education.
Logic and heuristic in education
Authors: Naziev Aslanbek
Published: May 2019

More than once were suggested that the results of the field of logic appear to be useful at the checking of ready-made proofs but refused to serve when one has to discover evidence; although some very reputable mathematicians supported this view, we allow ourselves to disagree with it. Every time they offer arguments for this point of view (and very often it speaks without any arguments), they demonstrate a â€˜frontalâ€™, straightforward interpretation of the results of logic. However, such an interpretation of the interrelations between logic and heuristic is not the only possible one. On the contrary, other interpretations possible, in which logic and heuristics are two sides of the single process of learning. In our paper, we consider both mentioned uses of the logic.

Keywords: Intuitive evidence, logical proof, heuristic advices.
Build history through educational competences in the degree of primary education
Authors: Molina Torres Maria Pilar
Published: May 2019

This work collects the results obtained from the teaching innovation project called: â€˜Building History through educational competences in the Degree of Primary Educationâ€™, carried out in the course 2017/2018. Different educational competences present in the curricular projects related to the area of Social Sciences were worked during its development. During the proposal, several practical activities will be carried out, such as small research works during the visit to the Archaeological Museum of Cordoba and the realisation of historical models related to the chosen theme in the didactic itinerary that will be included in a group classroom blog. The interaction of two different branches of knowledge (Social Sciences and Humanities) allowed us to work in an interdisciplinary way to concretise in practice the different activities. In fact, the purpose of this didactic experience is the application of these activities by the students to take them to a real classroom context.

Keywords: Primary education degree, educational competencies, methodology, historical heritage, cooperative work.
GeoGebra application, used in the determination of the magnitude of an earthquake
Authors: Chiriacescu Bogdan
Published: May 2019

In this paper, the authors tackle the earthquakes study with the aim of determining the magnitude. By means of a GeoGebra program (an open source programme), we encourage the secondary school scholars in modelling the data obtained from an actual earthquake. We intend to obtain the magnitude of an earthquake by a method that can be easily comprehended by the students. The model is based on Richterâ€™s approach. In order to facilitate the process, a GeoGebra application was created that allows for an accurate calculus. The instrument presented in this paper assists in a better understanding of the Richter scale (including how it was built) and the correlation between the energy released by the earthquake, the amplitude of the waves and the epicentral distance. The students will be able to analyse a seismogram, to identify its main elements and to determine the magnitude of a simulated earthquake.

Keywords: Earthquake, GeoGebra, seismogram, STEM, Richter scale.
Contextual learning strategies in the early stages of architecture education
Authors: Sahin Murat
Published: May 2019

The main objective of this paper is to present a series of interconnected contextual learning strategies applied in the early stages of architecture education. The study presents the design and implementation process of a term project assigned to first-year architecture students. It applied the contextual learning strategies by combining the autobiographical memory and design problem to explore unique narrative structure. This method allows for aligning multiple contexts-course content, the objective of the course, students profile, the learning environment and the basis of the design disciplines. The process was a performative one that involves storytelling, video making, quasi-research skills and informal discussions with parents and guardians to uncover and present the changing nature of the urban fabric as seen and understood by students. The results show that the students engaged and unearth various material within the contextual paradigm.

Keywords: Narrative reflection, contextual learning, alignment, architectural education.
The intervention: Improving social-emotional skills in early childhood as a factor of school performance
Authors: Monica Coste
Published: May 2019

Contemporary studies show the major impact of early education on the future development of children, that justifies a quality educational approach from the early childhood, to meet the needs of childrenâ€™s education for the onset of schooling. The dynamics of society and the updates in the field of education make it necessary to create an educational context as a response of the current needs of childrenâ€™s competencies. In many countries, social-emotional education gains importance as an essential element of education, emotional intelligence being considered a determinant for success in life. The methods used were the pedagogical experiment, surveys, curricular analysis and systematic observation. When children experience well-being, the ability to think is increased. The active involvement of the teachers in the implementation of the programme, the use of recommended practices and the solving of the challenges that have appeared have led to an increase in the impact of the intervention.

Keywords: Early childhood education, social-emotional skills, well-being, social-emotional education.
DIFFICULTIES OF THE CURRICULUM 2013 IMPLEMENTATION IN ARABIC LANGUAGE AT MADRASAH IBTIDAHYAH/ KESULITAN IMPLEMENTASI KURIKULUM 2013 MAPEL BAHASA ARAB PADA MADRASAH IBTIDAIYAH
Authors: Hadi Nurul
Published: May 2019

This research revealed the difficulties of the implementation of the 2013 Curriculum (K-13), especially in Arabic subject in Islamic Elementary Schools/ Madrasah Ibtidaiyah (MI) in Pamekasan, and the inhibiting factors. This study used qualitative research in the form of exploratory research, namely descriptive analysis. The population was all Islamic Elementary Schools (MI) in Pamekasan, and four schools were selected as samples by using purposive sampling technique.

The results showed that from the aspect of designing effective and meaningful learning, as well as in organizing learning, found that MI Islamiyah I Larangan Tokol, Tlanakan did not implement K-13 and did not have Arabic subject syllabus, and so did MI As-Salafi Sumber Duko Pakong. Even, the condition found in MIN 1 Konang, Galis as one of the State Islamic Elementary Schools in Pamekasan is almost the same as the Private Madrasah, because even though they have an Arabic subject syllabus, but it was still in print out syllabus, and the file is not formally legalized by the head of Madrasah. While, in the implementation of learning, it is revealed that teachers were not able to maximize the community, environment, media, and to utilize available internet connection in the learning practice. It happened in almost all Madrasah. Also, teachers of Madrasah Ibtidaiyah in Pamekasan need more training, guidance, and self-improvement in understanding the K-13 concept wholly and comprehensively. On the other hand, Madrasah Ibtidaiyah in Pamekasan did not yet maximize the K-13 concept in term of environmental empowerment as learning resources, and even it is undiscovered the use of andragogy approach, scientific approach, and active learning that should be applied in learning Arabic in Madrasah Ibtidaiyah in Pamekasan.

In general, there are three inhibiting factors which caused the difficulty in the implementation of K-13 in Madrasah Ibtidaiyah in Pamekasan; those include Madrasah and Government’s Policy, lack of qualified teachers, and inadequate facilities. As for the impacts of the difficulty of K-13 implementation for the students can be divided into two aspects: (1) the learning process, and (2) the learning outputs.

 
Keywords: difficulties of the implementation of the Curriculum 2013; Arabic; Madrasah Ibtidaiyah; Pamekasan regency
Export Competitiveness of Bangladesh Readymade Garments Sector
Authors: Hossian Md. Sajib , Kabir Rashedul , Latifee Enamul Hafiz
Published: May 2019

The paper evaluates the competitiveness of Bangladesh Readymade Garments (RMG) sector in the global RMG market through Market share analysis using two-digit classifications of Harmonized System (HS)data for the period covering 2012 to 2016 to understand the actual condition of sector’s export comparison with its competitors. While Trade Entropy index has also been calculated to make an attempt to understand the geographical dispersion of export market scenario using two-digit classifications of HS data for the time period between 2006 and 2016. The findings of the paper based on market share analysis illustrate that Bangladesh’s RMG export share in the global market reached 7.50percentin 2016, a shot up by 2.73 percentage points, indicating an increase in export competitiveness, whereas China’s share declined to 33.75 percentin 2016, with an exception to 2013. During this period, Vietnam and India’s market share increased by 2.24, and 0.72 percentage points respectively, making them the 3rd and 6th largest RMG exporter in the world. Trade Entropyindex calculationindicates that the geographical diversification of Bangladesh’s RMG export has increased considering the value of the index, it has increased more than two times during this time period. But, in spite of increasing geographical diversification of the RMG sector market, itsexport is still heavily concentrated on two markets: the European UnionEU (28), and the United States of America (USA). The paper also provides a set of policyrecommendations that wouldbe helpful to both RMG sector stakeholders and policymakers to move forward the sector towards more export competitiveness.
Consistent Model for Injection and Falloff Pressure Match of Diagnostic Fracture Injection Tests (DFITs)
Authors: Liu G.. , Ehlig–Economides C..
Published: May 2019

The diagnostic fracture injection test (DFIT), a fracture–injection/falloff test, is a reliable tool for quantifying the formation of closure stress, leakoff coefficient, formation permeability, and pressure. The current analytical DFIT model (used before and after closure) enables one to match the pressure falloff of abnormal leakoff behaviors, and quantifies more formation parameters than a traditional DFIT model. However, this model design addresses only the falloff data after shut–in; thus, analysts have expressed concerns that the net pressure implied by the falloff is inconsistent with the injection pressure behavior. Therefore, this paper provides a model capable of matching both injection and falloff pressure behaviors.

The pressure–falloff model is capable of quantifying essential pressure values including, in order of occurrence, instantaneous shut–in pressure (ISIP), minimum fracture–propagation pressure, one or more closure–stress values, formation minimum principal stress, and pore pressure. The early pressure response represents the dissipation of three kinds of friction—wellbore, perforation, and near–wellbore friction. Each of them is quantified, and, together, they comprise the difference between the pressure at the end of injection and the ISIP. Presence of tip extension enables the quantification of the minimum fracture–propagation pressure. The minimum principal stress is consistent with the final closure stress. Subtracting the closure stress and friction pressure losses from the recorded or calculated bottomhole pressure (BHP) provides the fracture net pressure. The model match for injection pressure behavior incorporates the same pressures and consistent values for 2D fracture geometry and leakoff coefficient.

The global match confirms not only the estimation of formation and fracture properties from the pressure–falloff analysis, but also the friction losses along the wellbore, through the perforations, and in the near–wellbore tortuosity during and after injection. In particular, by matching both injection and falloff, the model incorporates friction pressure losses that can explain apparent excessive net pressure.

The match with both injection and falloff pressure variation addresses concerns that the net pressure implied by the falloff model match cannot be consistent with the observed injection behavior. When the pressure difference between the final DFIT pick for closure stress and the pressure at the end of injection is large, the reason might be tip extension and/or large friction pressure losses, the latter of which can be addressed by the main treatment design.
QTL Mapping of Fusarium Head Blight Resistance in Winter Wheat Cultivars ‘Art’ and ‘Everest’
Authors: Clinesmith Marshall A. , Fritz Allan K. , Lemes da Silva Cristiano , Bockus William W. , Poland Jesse A. , Dowell Floyd E. , Peiris Kamaranga H. S.
Published: May 2019

Fusarium head blight (FHB) is a disease of small grains most commonly associated with the fungal pathogen Fusarium graminearum. Development and deployment of resistant cultivars has proved to be an effective method to combat the disease; however, the majority of major resistance has historically been found in exotic material. Transferring resistance from these sources into locally adapted cultivars has been a slow process due to linkage drag. Therefore, it is important for breeders to search for sources of resistance in native material. This study was conducted to identify quantitative trait loci (QTL) for resistance to spread of FHB within the spike (Type II resistance), accumulation of deoxynivalenol toxin in grain (Type III resistance), and resistance to kernel infection (Type IV resistance) using a doubled‐haploid population developed from a cross between the hard red winter wheat (Triticum aestivum L.) cultivars Art and Everest. Four QTL conferring resistance to FHB traits were detected on chromosomes 2D, 4B, and 4D. Qfhb.ksu‐2D, located on the short arm of 2D, is located near the major photoperiod gene Ppd‐D1 and was associated with all three FHB traits. Qfhb.ksu‐2D.1 is on the long arm of 2D and was associated with percentage symptomatic spikelets (PSS). The QTL on chromosomes 4B and 4D were associated with PSS and overlapped with the major height genes Rht‐B1 and Rht‐D1, respectively. In this study, the haplotype analysis for Ppd‐D1 showed significant associations between the photoperiod‐sensitive allele Ppd‐D1b and lower levels of all three FHB traits. The haplotype analysis for the Rht‐B1 and Rht‐D1 loci showed significant associations between the dwarfing alleles and increased resistance to PSS.
Activity, Purification, and Analysis of Condensed Tannins: Current State of Affairs and Future Endeavors
Authors: Zeller Wayne E.
Published: May 2019

As a class of plant polyphenolic compounds contained in some forages (i.e., sainfoin [Onobrychis viciifolia Scop.], big trefoil [Lotus pedunculatus Cav.], birdsfoot trefoil [Lotus corniculatus L.]), condensed tannins (CTs), also referred to as proanthocyanidins (PAs or PACs), exhibit a variety of biological effects on ruminants. The potential positive impact of CTs on the agricultural industry stems from their ability to modulate proteolysis during forage conservation and ruminal digestion, to prevent bloat, to reduce intestinal parasite burdens, to abate methane and ammonia emissions from ruminants, and to inhibit the activity of soil‐nitrifying bacteria. How CTs exert these effects on ruminants focuses on the interaction of CTs with proteins. The structure‐activity relationship in CT–protein interaction is not well understood but is known to be dependent on the structure and properties of both the CT and the protein. The purpose of this perspective is fivefold. First, we provide the reader with a better understanding of the structural diversity of CTs present in plant material and enable the reader to appreciate that not all CTs are the same. Second, we provide examples of how CT structural diversity affects the interaction of CTs with the protein, which, in turn, dictates the biological response from the animal. Third, we describe the hurdles in obtaining highly pure and well‐characterized CTs from natural sources for use in studies to attempt to elucidate how CTs impart each biological effect. We then describe improved and emerging techniques for CT analysis and, finally, we conclude this perspective with questions to address in future investigations and forward a list of recommendations for CT researchers to follow.
Reimagining Maize Inbred Potential: Identifying Breeding Crosses Using Genetic Variance of Simulated Progeny
Authors: Beckett Travis J. , Rocheford Torbert R. , Mohammadi Mohsen
Published: May 2019

Proper choice of parents for breeding populations is essential in developing new maize (Zea mays L.) inbreds for improved hybrid performance. Breeders have frequently chosen parental combinations based on mid‐parent (MP) value, or predicted progeny mean, to combine favorable traits from the two parents. When two breeding populations have the same MP value, an accurate prediction of progeny variance may reveal which population has a greater potential for genetic gain. In this study we used available inbred genotypes and new hybrid phenotypes from 246 inbreds with expired Plant Variety Protection certificates and 39 historically important North American dent inbreds, all test crossed to Iodent inbred PHP02. We used the R package ‘PopVar’ to simulate biparental populations and perform genome‐wide prediction to predict the progeny mean, genetic variance, and superior progeny mean for grain yield, grain moisture, and test weight within each virtual population. Breeding crosses were ranked based on the mean grain yield of superior progeny and correlated trait responses for test weight and moisture. Results show that combining germplasm from different proprietors in new breeding crosses can produce inbreds with improved performance in a hybrid test cross. The simulation and prediction model presented in this study may help breeders to identify parental pairs with the greatest potential for genetic gain in hybrid crop breeding programs.
Morphological Traits Underlying Differences in Early Vigor among Four Cotton Genotypes
Authors: Liu Shengjun , Remley Melissa , Nichols Robert L. , Fritschi Felix B.
Published: May 2019

In comparison with other annual crops, cotton (Gossypium hirsutumL.) seedlings develop slowly after emergence. More rapid seedling development can provide advantages in limiting disease, insect, and weed impacts on cotton seedlings. Information on the mechanisms determining early vigor in cotton is limited. Therefore, three genotypes previously identified to differ in seedling vigor and one commercial cultivar were selected for detailed characterization of early growth in greenhouse and field conditions. Growing environment and genotype effects were significant for many of the measured traits. Environmental conditions prevailing in field and greenhouse conditions differentially affected seedling growth, including cotyledon biomass, root weight ratio (RWR), net assimilation rate (NAR), and specific leaf area (SLA). Genotypic differences were found in one or both environments for cotyledon area, area of the first leaf, total leaf area, and leaf, stem, root, and total biomass. Leaf weight ratio (LWR), stem weight ratio (SWR), RWR, LAR, and SLA differed among genotypes at most stages, but this was not the case for relative growth rate and NAR. The high‐vigor genotype generally had longer roots, larger cotyledons, greater cotyledon, stem, and total biomass, and greater SWR and RWR than the low‐vigor genotype. The low‐vigor genotype had the greatest LAR, SLA, and LWR among the four genotypes. Results obtained in this study suggest that factors such as the efficiency of photoassimilate conversion into biomass, energy density of the biomass, root carbon exudation, and/or photosynthetic rates differ between the low‐vigor and high‐vigor genotypes.
Reactive Transport of Manure‐Derived Nitrogen in the Vadose Zone: Consideration of Macropore Connectivity to Subsurface Receptors
Authors: Hussain Syed I. , Frey Steven K. , Blowes David W. , Ptacek Carol J. , Wilson David , Mayer K. Ulrich , Su Danyang , Gottschall Natalie , Edwards Mark , Lapen David R.
Published: May 2019

Core Ideas

Manure N transformation was modeled with different soil pore connectivities to tile drains.

Macropores facilitated NH4+oxidation reaction products deeper in the profile.

Nitrate losses to tile were best predicted by models using pores connected to tile drains.

Macropores can be important conduits for surface‐derived nutrients to reach subsurface receptors. Accordingly, nutrient reactive transport processes in macroporous soils need to be well understood. In this study, steady‐state two‐dimensional reactive transport simulations with MIN3P‐THCm (version 1.0.519.0) were used to elucidate how soil macropore connectivity to tile drains can influence N transformations following liquid swine manure (LSM) applications to soil. Four different soil scenarios were considered: homogeneous sand, homogeneous clay loam, and clay loam with discrete macropores connected to or disconnected from the bottom boundary used to represent tile drain outflow. In relation to the homogeneous soils, macropores, overall, facilitated chemical diffusion into the adjacent soil matrix along their length and broadly augmented O2ingress into the soil profile. These processes combined to critically control the spatial distribution of NH4+oxidation reaction products. When used in transient simulation mode with field data observed at experimental tile‐drained plots that received LSM application, the model showed that simulated nitrate mass losses to tile are considerably higher and most realistic under the connected macropore scenario compared with the homogeneous or disconnected macropore scenarios.
Working arrangements for consultant anaesthetists in the UK (ARCHIVED)
Authors:   Association of Anaesthetists, Clyburn Paul , Ferguson Kathleen , Geraghty Ian , Harrop-Griffiths William , Harwood Robert , Maguire Peter , Porter Mark , Shewry Elizabeth , Sneyd Robert
Published: May 2019

A contract is nothing more than an enforceable agreement that regulates the relationship between two parties. In the case of the 2003 consultant contracts, the two parties are the employer and employee, or consultant and their employing health authority, NHS Trust or Board. The 2003 consultant contracts were negotiated in order to address changes in the way the NHS and consultants had been working over the preceding few years, and to prepare for future developments. These guidelines include: Principles of the 2003 consultant contract; DCC Pas and their calculation; SPAs and their justification; WTR – rest and work patters; Leave of all sorts; On-call; Part-time and flexible working; Job planning and changes to job plans; Academic contracts; Differences in devolved nations; The pre-2003 contract; Starting out as a consultant.
Antihyperalgesic Activity of Quillaic Acid Obtained from Quillaja Saponaria Mol.
Authors: Arrau Sylvia , Rodríguez-Díaz Maité , Cassels Bruce K. , Valenzuela-Barra Gabriela , Delporte Carla , Barriga Andrés , Miranda Hugo F.
Published: May 2019

Background:

Quillaja saponaria Mol. bark contains a high concentration of triterpene saponins
that have been used for centuries as a cleansing, antiinflammatory and analgesic agent in Chilean folk
medicine. In earlier studies, in mice, both the anti-inflammatory as well as the antinociceptive effect of
the major sapogenin, quillaic acid have been demonstrated (QA).

Objective:

To determine the antihyperalgesic effect of QA one and seven days after itpl administration of
complete Freund's adjuvant (CFA) in male mice using the hot plate test in the presence of complete Freund's
adjuvant (HP/CFA) as an acute and chronic skeletal muscle pain model.

Methods:

The present study evaluated the antihyperalgesic activity of QA against acute and chronic
skeletal muscle pain models in mice using the hot plate test in the presence of complete Freund's adjuvant
(HP/CFA), at 24 h (acute assay) and 7 days (chronic assay) , with dexketoprofen (DEX) as the reference
drug.

Results:

In acute and chronic skeletal muscle pain assays, QA at 30 mg/kg ip elicited its maximal antihyperalgesic
effects (65.0% and 53.4%) at 24 h and 7 days, respectively. The maximal effect of DEX
(99.0 and 94.1 at 24 h and 7 days, respectively) was induced at 100 mg/kg.

Conclusion:

QA and DEX elicit dose-dependent antihyperalgesic effects against acute and chronic skeletal
muscle pain, but QA is more potent than DEX in the early and late periods of inflammatory pain induced
by CFA.
Higher-Order and Mixed Discrete Derivatives such as a Novel Graph- Theoretical Invariant for Generating New Molecular Descriptors
Authors: Martínez-Santiago Oscar , Marrero-Ponce Yovani , Vivas-Reyes Ricardo , Ugarriza Mauricio E.O. , Hurtado-Rodríguez Elízabeth , Martínez-López Yoan , Torres F. Javier , Zambrano Cesar H. , Pham-The Hai
Published: May 2019

Background:

Recently, some authors have defined new molecular descriptors (MDs) based on the
use of the Graph Discrete Derivative, known as Graph Derivative Indices (GDI). This new approach about discrete
derivatives over various elements from a graph takes as outset the formation of subgraphs. Previously,
these definitions were extended into the chemical context (N-tuples) and interpreted in structural/physicalchemical
terms as well as applied into the description of several endpoints, with good results.

Objective:

A generalization of GDIs using the definitions of Higher Order and Mixed Derivative for molecular
graphs is proposed as a generalization of the previous works, allowing the generation of a new family of MDs.

Methods:

An extension of the previously defined GDIs is presented, and for this purpose, the concept of Higher
Order Derivatives and Mixed Derivatives is introduced. These novel approaches to obtaining MDs based on the
concepts of discrete derivatives (finite difference) of the molecular graphs use the elements of the hypermatrices
conceived from 12 different ways (12 events) of fragmenting the molecular structures. The result of applying
the higher order and mixed GDIs over any molecular structure allows finding Local Vertex Invariants (LOVIs)
for atom-pairs, for atoms-pairs-pairs and so on. All new families of GDIs are implemented in a computational
software denominated DIVATI (acronym for Discrete DeriVAtive Type Indices), a module of KeysFinder
Framework in TOMOCOMD-CARDD system.

Results:

QSAR modeling of the biological activity (Log 1/K) of 31 steroids reveals that the GDIs obtained using
the higher order and mixed GDIs approaches yield slightly higher performance compared to previously reported
approaches based on the duplex, triplex and quadruplex matrix. In fact, the statistical parameters for
models obtained with the higher-order and mixed GDI method are superior to those reported in the literature by
using other 0-3D QSAR methods.

Conclusion:

It can be suggested that the higher-order and mixed GDIs, appear as a promissory tool in
QSAR/QSPRs, similarity/dissimilarity analysis and virtual screening studies.
Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity
Authors: Caballero-Alfonso Ana Yisel , Cruz-Monteagudo Maykel , Tejera Eduardo , Benfenati Emilio , Borges Fernanda , Cordeiro M. Natália D.S. , Armijos-Jaramillo Vinicio , Perez-Castillo Yunierkis
Published: May 2019

Background:

Malaria or Paludism is a tropical disease caused by parasites of the Plasmodium
genre and transmitted to humans through the bite of infected mosquitos of the Anopheles genre.
This pathology is considered one of the first causes of death in tropical countries and, despite several
existing therapies, they have a high toxicity. Computational methods based on Quantitative Structure-
Activity Relationship studies have been widely used in drug design work flows.

Objective:

The main goal of the current research is to develop computational models for the identification
of antimalarial hit compounds.

Materials and Methods:

For this, a data set suitable for the modeling of the antimalarial activity of
chemical compounds was compiled from the literature and subjected to a thorough curation process. In
addition, the performance of a diverse set of ensemble-based classification methodologies was evaluated
and one of these ensembles was selected as the most suitable for the identification of antimalarial
hits based on its virtual screening performance. Data curation was conducted to minimize noise.
Among the explored ensemble-based methods, the one combining Genetic Algorithms for the selection
of the base classifiers and Majority Vote for their aggregation showed the best performance.

Results:

Our results also show that ensemble modeling is an effective strategy for the QSAR modeling
of highly heterogeneous datasets in the discovery of potential antimalarial compounds.

Conclusion:

It was determined that the best performing ensembles were those that use Genetic Algorithms
as a method of selection of base models and Majority Vote as the aggregation method.
Regulation of Myocardial Extracellular Matrix Dynamic Changes in Myocardial Infarction and Postinfarct Remodeling
Authors: Ushakov Alexey , Ivanchenko Vera , Gagarina Alina
Published: May 2019

The article represents literature review dedicated to molecular and cellular mechanisms underlying clinical manifestations and outcomes of acute myocardial infarction. Extracellular matrix adaptive changes are described in detail as one of the most important factors contributing to healing of damaged myocardium and post-infarction cardiac remodeling. Extracellular matrix is reviewed as dynamic constantly remodeling structure that plays a pivotal role in myocardial repair. The role of matrix metalloproteinases and their tissue inhibitors in fragmentation and degradation of extracellular matrix as well as in myocardium healing is discussed. This review provides current information about fibroblasts activity, the role of growth factors, particularly transforming growth factor β and cardiotrophin-1, colony-stimulating factors, adipokines and gastrointestinal hormones, various matricellular proteins. In conclusion considering the fact that dynamic transformation of extracellular matrix after myocardial ischemic damage plays a pivotal role in myocardial infarction outcomes and prognosis, we suggest a high importance of further investigation of mechanisms underlying extracellular matrix remodeling and cell-matrix interactions in cardiovascular diseases.
The Use of Milrinone Versus Conventional Treatment for the Management of Life-Threatening Bronchial Asthma
Authors: Sobhy Amr , K. Eldin Doaa M. , Zaki Hany V.
Published: May 2019

Background and Aims:

In our study, we investigated the effectiveness of intravenous milrinone in life-threatening bronchial asthma as compared to conventional treatment.

Methods:

Fifty patients aged 18-50 years, presenting with life-threatening asthma were enrolled in a Randomised Controlled Trial (RCT). They were randomly allocated intoGroup C(25 patients): who received the standard pharmacotherapy and placebo, andGroup M(25 patients): who in addition to the standard therapy, received 25 μg milrinone as an initial slow IV bolus diluted in 10 ml of normal saline. The following data were recorded: PEFR (Peak Expiratory Flow Rate) expressed as a percentage of the patient’s previous value, Respiratory Rate (RR), MABP (Mean Arterial Blood Pressure), arterial blood gases, and the number of patients requiring mechanical ventilation. Differences between groups were tested using Analysis of Variance (ANOVA) for quantitative variables with post hoc using the Least Significant Difference (LSD) test, and Chi square test for categorical variables.

Results:

Group M showed marked improvement in PEFR that was highly significant (P< 0.001) 10 min after injection and significant after one hour from the start of treatment in comparison to Group C. There was also an improvement in RR and PO2that was significant in group M. Milrinone was associated with a reduction in MABP only after 10 min from injection, and showed a statistically significant decrease in the number of patients requiring mechanical ventilator support (P˂ 0.05).

Conclusion:

Milronine is a promising agent as a rescue drug in the treatment of life-threatening bronchial asthma.
MEASUREMENT OF DIELECTRIC PERMITTIVITY OF GASES UNDER HIGH PRESSURE IN DECIMETER WAVELENGTH RANGE
Authors: Kravchenko V. V. , Prusov A. V.
Published: May 2019

The paper considers the development of a device for measuring the relative permittivity of high-pressure gases in the decimeter wavelength range. It is shown that the tunable short-circuit at high pressures of the order of several MPa cannot contain nodes of mechanical tuning of the length of the frequency-setting resonator. A method is proposed for tuning the frequency resonator filled with the measured gas by filling the electrolyte between the pairs of dielectric walls inside the resonator. It is indicated that when selecting the electrolyte and the material of the dielectric walls, care should be taken that the electrolyte does not wet the dielectric walls when pouring. The authors carried out an estimated calculation of the concentration of liquid electrolyte and its resistance. The method of measuring the relative dielectric constant of gases under different pressures is described. The results of measurements and the frequency dependences of the relative dielectric constant of the polar gas of NH3 for pressures of 105 Pa and 2 MPa at 300 K are presented.
Leading Internationalization—A Handbook for International Education Leaders (Note 1)
Authors: Baniadam Ismail , Heydarlou Nasim Meskini , Bakir Siddik
Published: May 2019

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PENGARUH INFLASI, SUKU BUNGA, DAN NILAI TUKAR RUPIAH TERHADAP INDEKS HARGA SAHAM GABUNGAN (IHSG) DI BURSA EFEK INDONESIA
Authors: Sukamto Siska Wahyuni
Published: May 2019

This studi was conducted to determine the effect macro economic variable of inflation, interest rate, and exchange rate againts the stock price indeks on indonesia stock exchange, and look for variables that effect most dominant among the three variables in the stock price index. Type of research is quantitative research, using multiple regression analysis, F test, t test and standardized coefficient as a tool of analysis in this study. Results of the study found that the variables inflation, interest rate, and exchange rate either simultaneously is significant effect on stock price index. Either partially the inflation variable has a significant effect on stock price index, while the variable interest rate have a significant negative effect on the stock price index, and the exchange rate has a significant effect on the stock price index, inflation variable are the most dominany effect on stock price index on Indonesia Stock Exchange
PENGARUH KOMPENSASI FINANSIAL LANGSUNG TERHADAP TURNOVER INTENTION DENGAN KEPUASAN KERJA SEBAGAI VARIABEL INTERVENING (Pada Ratu Swalayan Dampit Kabupaten Malang)
Authors: Agustin Denny Irawati
Published: May 2019

This study aim describing direct financial compensation and turnover intention in Ratu Supermarket, Dampit, Malang Regency, determining influence of direct financial compensation on employees’ turnover intention, and identifying job satisfaction that mediates the influence of direct financial compensation on the turnover intention in Ratu Supermarket, Dampit,Malang Regency.The population was all employees amounted to 32 people. The sampling technique used was population sample, in which all population was used as the sample.Data collection techniques used interviews, questionnaires and documentation. The data were analyzed by using Path Analysis and Sobel Test. The result of the study showed that direct financial compensation had a good criteria whereas job satisfaction had a high criteria, and turnover intention have a high criteria. From the Path Anlysis and Sobel Test, it indicates that direct financial compensation had a significant influence on turnover intention, and the other Path Anlysis showed that direct financial compensation and job satisfaction had significant influence on turnover intention. The result of the analysis confirmed that job satisfaction could mediate direct financial compensation that influence the turnover intention in Ratu Supermarket, Malang Regency.
Efecto de la temperatura sobre la tasa de consumo del vitelo y gota de aceite en las larvas del pargo flamenco Lutjanus guttatus (Perciformes: Lutjanidae)
Authors: Abdo-de la Parra María Isabel , Rodríguez-Montes de Oca Gustavo Alejandro , Rodríguez-Ibarra L. Estela , Román-Reyes José Cristóbal , Velasco-Blanco Gabriela
Published: May 2019

El vitelo es la principal fuente de energía para huevos y larvas vitelinas de peces marinos. La temperatura tiene un papel dominante en la eficiencia de la conversión del vitelo en tejido corporal y afecta el tamaño que puede alcanzar la larva en la primera alimentación. En el presente trabajo se evaluó el efecto de diferentes temperaturas sobre el consumo del saco vitelino y la gota de aceite de pargo flamenco, Lutjanus guttatus, para determinar la temperatura adecuada de cultivo para larvas vitelinas. Los huevos fertilizados de pargo flamenco se colocaron en tinas de plástico de 20 L a temperaturas de 22, 25, 28 y 31 °C con tres réplicas por tratamiento. Se determinó el tiempo y porcentaje de eclosión, longitud total, tasas de consumo de vitelo (TCV) y de gota de aceite (TCGA) a las 0, 24, 48 y 72 h después de la eclosión (HDE). Los huevos incubados a 22 °C no eclosionaron. No se observaron diferencias significativas en el porcentaje de eclosión entre tratamientos de 25, 28 y 31°C. Las larvas a 31 °C presentaron mayor longitud al eclosionar y menor HDE que las que estuvieron a 25 °C. La TCV y TCGA fue mayor en las larvas a 31 °C a 0 y 24 HDE. Se presentó mortalidad total en las larvas incubadas a 25 y 31 °C a las 48 y 72 HDE, respectivamente. La temperatura adecuada para la incubación de huevos y larvas de L. guttatus se debe llevar a cabo a 28 °C para favorecer el consumo de sus reservas energéticas adecuado para su crecimiento y supervivencia.
Condición reproductiva de la jibia Dosidicus gigas en la zona costera del centro-sur de Chile
Authors: Ibáñez Christian M. , López-Córdova David , Zúñiga Arnaldo , Arancibia Hugo
Published: May 2019

La condición reproductiva de la jibia Dosidicus gigas no se conoce bien en Chile, aunque se ha sugerido un patrón migratorio oceánico-costero durante la maduración y desove. El objetivo de este estudio fue describir la condición reproductiva de la jibia en la zona costera del centro-sur de Chile. Para esto, se analizaron 1.335 especímenes de enero a diciembre de 2014 para estimar su madurez sexual macroscópica e índice gonadosomático (IGS). La proporción sexual mostró desviaciones de 1:1 en todos los meses con una alta dominancia de hembras en enero. Se encontraron diferencias significativas en el IGS entre sexos y meses, mientras que las etapas de madurez fueron relativamente constantes a lo largo del tiempo. La mayoría de los calamares registrados eran inmaduros, y solo se encontraron dos hembras maduras, lo que sugiere que el desove se produce en aguas oceánicas en Chile.
Integrating of the seahorse Hippocampus reidi in multi-trophic organic farms of oysters and shrimp: Effects of density and diet
Authors: Carvalho Thiago L. , Cacho Julio Cesar S. , Souza Rafaela S. , Morais Jefferson A. , Wandeness Adriane , Carlos Marco Tulio L. , Wainberg Alexandre A. , Souza-Santos Lília P. , Ribeiro Felipe A. S.
Published: May 2019

The goal of this study was to demonstrate the feasibility of culturing the seahorse Hippocampus reidi in an organic integrated multi-trophic aquaculture farm that produces the oyster Crassostrea brasiliana and the shrimp Litopenaeus vannamei. Experiments were conducted to evaluate the effects stocking density and food (natural zooplankton, Artemia nauplii, or both) for the juvenile I, which are fish from 1 to 15 days after birth. Stocking density effect was studied on growth and survival of juveniles II from 30 days to commercial size in net cages. Survival of the juvenile I was not affected by stocking densities from 2 to 5 ind L-1 and was greater than 70% in all treatments. Seahorse length, however, was inversely related to stocking density. Both treatments with wild zooplankton promoted higher seahorse survival and growth than diet composed exclusively by Artemia sp. during the first 15 days of life. Juvenile II growth decreased with stocking density from 5 to 40 ind m-3 but survival was not affected by it. The total benefit and proportion of colored animals increased significantly with stocking density. The present study confirms the technical feasibility of organic multi-trophic seahorse production in net cages. Even at the highest density tested the seahorses grew well and could generate high profits.
Diversidad, abundancia y frecuencia de argonautas (Cephalopoda: Argonautidae), en la dieta de peces pelágicos de importancia comercial en Oaxaca, México
Authors: Alejo-Plata María del Carmen , León-Guzmán Sairi Sarai , Díaz-Polo Román , Torres-Huertal Ana María
Published: May 2019

Los argonautas son una familia de pulpos pelágicos con amplia distribución en aguas tropicales y subtropicales del océano mundial, cuya presencia es notable en la dieta de diversas especies de peces pelágicos con valor comercial. En el presente estudio se evaluó la diversidad, abundancia relativa y frecuencia de este grupo de cefalópodos presentes en el contenido gástrico de 7 especies de peces (4 teleósteos y un elasmobranquio), capturados por la pesquería artesanal del estado de Oaxaca, México. Se examinaron  778 estómagos obtenidos de muestreos mensuales durante 2016 y 2017. Los argonautas fueron las presas más representativas del grupo octopoda (98%) y el segundo grupo más importante de cefalópodos (35%) después de los calamares (42,5%). Un total de 273 hembras correspondientes a 3 especies de argonautas fueron analizadas: Argonauta nouryi (45,6%), A. argo (20,8%), y A. hians (33,6%). Se observaron dos tipos en las conchas de A. nouryi: tipo A. nouryi (16,3%) y tipo A. cornuta (29,3%). De este modo, se destaca la utilidad de los estudios de alimentación en peces depredadores pelágicos para llevar a cabo la captura y el estudio bioecológico de argonautas en el Pacífico tropical oriental.
Determinantes de la informalidad laboral en Colombia para el período 2008 – 2017
Authors: Berrio-Calle Juan Esteban , Bran-Piedrahita Lemy
Published: May 2019

El objetivo de esta investigación es identificar los determinantes clave que explican la informalidad laboral en Colombia, para el período 2008 – 2017. En el proceso se utilizó un enfoque metodológico cuantitativo, de tipo descriptivo, para ello se emplearon datos de la Gran Encuesta Integrada de Hogares (GEIH), realizada por el Departamento Administrativo Nacional de Estadística (DANE), además de diversas fuentes referenciales de la literatura, donde los determinantes se catalogaron como cíclicos y acíclicos, dependiendo de su comportamiento, respecto al ciclo económico. Los análisis arrojan que Bogotá, Medellín, Manizales, Pereira y Cali, presentan las tasas de informalidad más bajas (entre 40 % y 50 %). Adicionalmente, entre las conclusiones resalta que existe una relación lineal o directa entre la duración del desempleo y la informalidad; a mayor tiempo en calidad de desempleado, mayor probabilidad de caer en la informalidad.
A teoria da derivação do estado e o debate (alemão) do mercado mundial
Authors: Osorio Luiz Felipe
Published: May 2019

Em meio a um contexto de crises econômicas e políticas, dentro da celebração do centenário da Revolução Russa e do bicentenário de Marx, o atual é voltar às origens marxianas para a compreensão da anatomia da sociedade capitalista. A mola mestra para a manutenção do modo de produção, o Estado, precisa ser destrinchada em sua real concretude. Para tanto, cabe entender o Estado enquanto forma política do capitalismo, como propõe o debate da derivação do Estado. Ainda, a unidade política territorial requer ser inserida no âmbito que busca oxigênio, as relações internacionais, as quais manifestam a plena manifestação do capitalismo. Logo, o dentro das teorias da derivação, vem o debate (alemão) do mercado mundial, que traz a contribuição central para a sobrevivência do capitalismo: a multiplicidade estrutural de Estados.
Formas sociais, derivação e conformação
Authors: Mascaro Alysson Leandro
Published: May 2019

Uma rigorosa compreensão da sociabilidade a partir das formas sociais contrasta tanto com velhas leituras marxistas, mais dadas a algum grau de historicismo, quanto com o institucionalismo liberal do pensamento universitário atual. Há determinação social pela mercadoria e pelo valor, a partir do trabalho abstrato: o fundamento da determinação é a produção. A equivalência entre mercadorias e entre seus possuidores erige formas por cujos constructos articulam-se as relações sociais. Das formas nucleares da sociabilidade capitalista derivam uma forma política estatal e uma forma de subjetividade jurídica, específicas de tal modo de produção e inexoráveis a ele. A derivação de formas sociais se faz atravessada por contradições e antagonismos factuais. Tais formas derivadas conformam-se em derivação secundária.
Apreciação Técnica de Modelo de Esfigmomanômetros Digitais
Authors: Azeredo Ronaldo N. , Pereira Renata A. R. , Sant’Ana Flavio W. , Neto José A. G.
Published: May 2019

Será apresentado um panorama dos resultados obtidos nos processos de apreciação técnica de modelo de esfigmomanômetros digitais, realizados pela Diretoria de Metrologia Legal do Inmetro entre janeiro de 2007 e dezembro de 2008.