bluuebunny/crossref_metadata_2025 huggingface dataset:
Composition of Three Common Chinese Herbal Medicines and the Influence of Preparation Types on the Bioaccessibility of Trace Elements
Authors: Wan Xiaoming , Zeng Weibin
Published: November 2022

The high concentration of trace elements in Chinese herbal medicine (CHM) is an important research topic for quality control. This study investigated the total concentration of trace elements in three herbs used as both medicine and supplementary food, including Astragalus membranaceus, Glycyrrhiza, and Isatidis. Further, the effects of different preparation ways, such as decoct, granule, and oral liquid, on the bioaccessibility of trace elements in CHM were disclosed. Results indicated that the total concentrations of trace elements in these three herbs were lower than the medical standards, but the concentrations of As and Pb in CHMs were higher than the standards for supplementary food. Different preparations ways affect bioaccessibility. Powder and oral liquid show a high bioaccessibility possibly because of the grinding process and the repeated extraction with ethanol. Among the three different CHMs, Isatidis showed higher bioaccessibility of As, which may be related to the sulfur fumigation process of this CHM. The three investigated CHMs were found to be safe as medicine but presented risks as supplementary food. The apparent influence of preparation procedures on the bioaccessibility of trace elements indicated that it is necessary to appropriately regulate preparation processes for CHMs.
Epidemiological Criminology and COVID: A Transdisciplinary Analysis of Violent Crime and Emergency Department Admissions during COVID
Authors: Wylie Lindsey , Garman Julie , Armstrong Gaylene , Farrens Ashley , Burt Jennifer , Foxall Mark , Visenio Michael , Cox Macall , Hernandez Cynthia , Evans Charity , Raposo-Hadley Ashley Ann
Published: November 2022

As little is known about the influence of COVID-19 on rates of violent crime, the purpose of this study is to examine violent injury captured by emergency department admissions and by law enforcement in a mid-sized midwestern city (Omaha, Nebraska) from January 2016 to December 2020. Although COVID-19 did not show a direct significant relationship, weeks during the COVID-19 period showed a marginal increase in incident rate ratios for violent incidents in both datasets. While violence remained stable during the pandemic, racial differences between samples were observed. This study emphasizes the utility of a transdisciplinary approach to understand the underlying drivers of violent crime and victimization.
On Propagation in Loop Quantum Gravity
Authors: Thiemann Thomas , Varadarajan Madhavan
Published: November 2022

A rigorous implementation of the Wheeler–Dewitt equations was derived in the context of Loop Quantum Gravity (LQG) and was coined Quantum Spin Dynamics (QSD). The Hamiltonian constraint of QSD was criticised as being too local and to prevent “propagation” in canonical LQG. That criticism was based on an algorithm developed for QSD for generating solutions to the Wheeler–DeWitt equations. The fine details of that algorithm could not be worked out because the QSD Hamiltonian constraint makes crucial use of the volume operator, which cannot be diagonalised analytically. In this paper, we consider the U(1)3 model for Euclidean vacuum LQG which consists of replacing the structure group SU(2) by U(1)3 and otherwise keeps all properties of the SU(2) theory intact. This enables analytical calculations and the fine details of the algorithm ingto be worked out. By considering one of the simplest possible non-trivial classes of solutions based on very small graphs, we show that (1) an infinite number of solutions ingexist which are (2) generically not normalisable with respect to the inner product on the space of spatially diffeomorphism invariant distributions and (3) generically display propagation. Due to the closeness of the U(1)3 model to Euclidean LQG, it is extremely likely that all three properties hold also in the SU(2) case and even more so in physical Lorentzian LQG. These arguments can in principle be made water tight using modern numerical (e.g., ML or QC) methods combined with the techniques developed in this paper which we reserve for future work.
Evolution of SARS-CoV-2: BA.4/BA.5 Variants Continues to Pose New Challenges
Authors: Quadir Neha , Singh Jasdeep , Alam Anwar , Malik Asrar Ahmad , Rahman Syed Asad , Hira Subhash , Ehtesham Nasreen Zafar , Sundar Durai , Hasnain Seyed Ehtesham
Published: November 2022

The acquisition of a high number of mutations, notably, the gain of two mutations L452R and F486V in RBD, and the ability to evade vaccine/natural infection-induced immunity suggests that Omicron is continuing to use “immune-escape potential” as an evolutionary space to maintain a selection advantage within the population. Despite the low hospitalizations and lower death rate, the surges by these variants may offset public health measures and disrupt health care facilities as seen recently in Portugal and the USA. Interestingly these BA.4/BA.5 variants have been found to be more severe than the earlier-emerged Omicron variants. We believe that aggressive COVID-19 surveillance using affordable testing strategies might actually help understand the evolution and transmission pattern of new variants. The sudden dip in reporting of new cases in some of the low- and middle-income countries is an alarming situation and needs to be addressed as this could lead to undetected transmission of future variants of interest/concern of SARS-CoV-2 in large population settings, including advent of a ‘super’ virus. It would be interesting to examine the possible role/influence, if any, of the two different kinds of vaccines, the spike protein-based versus the inactivated whole virus, in the evolution of BA.4/BA.5.
Bacteriophage Cocktails in the Post-COVID Rehabilitation
Authors: Zurabov Fedor M. , Chernevskaya Ekaterina A. , Beloborodova Natalia V. , Zurabov Alexander Yu. , Petrova Marina V. , Yadgarov Mikhail Ya. , Popova Valentina M. , Fatuev Oleg E. , Zakharchenko Vladislav E. , Gurkova Marina M. , Sorokina Ekaterina A. , Glazunov Egor A. , Kochetova Tatiana A. , Uskevich Victoria V. , Kuzovlev Artem N. , Grechko Andrey V.
Published: November 2022

Increasing evidence suggests that gut dysbiosis is associated with coronavirus disease 2019 (COVID-19) infection and may persist long after disease resolution. The excessive use of antimicrobials in patients with COVID-19 can lead to additional destruction of the microbiota, as well as to the growth and spread of antimicrobial resistance. The problem of bacterial resistance to antibiotics encourages the search for alternative methods of limiting bacterial growth and restoring the normal balance of the microbiota in the human body. Bacteriophages are promising candidates as potential regulators of the microbiota. In the present study, two complex phage cocktails targeting multiple bacterial species were used in the rehabilitation of thirty patients after COVID-19, and the effectiveness of the bacteriophages against the clinical strain of Klebsiella pneumoniae was evaluated for the first time using real-time visualization on a 3D Cell Explorer microscope. Application of phage cocktails for two weeks showed safety and the absence of adverse effects. An almost threefold statistically significant decrease in the anaerobic imbalance ratio, together with an erythrocyte sedimentation rate (ESR), was detected. This work will serve as a starting point for a broader and more detailed study of the use of phages and their effects on the microbiome.
Rhinovirus Infection and Virus-Induced Asthma
Authors: Hayashi Yuriko , Sada Mitsuru , Shirai Tatsuya , Okayama Kaori , Kimura Ryusuke , Kondo Mayumi , Okodo Mitsuaki , Tsugawa Takeshi , Ryo Akihide , Kimura Hirokazu
Published: November 2022

While the aetiology of asthma is unclear, the onset and/or exacerbation of asthma may be associated with respiratory infections. Virus-induced asthma is also known as virus-associated/triggered asthma, and the reported main causative agent is rhinovirus (RV). Understanding the relationship between viral infections and asthma may overcome the gaps in deferential immunity between viral infections and allergies. Moreover, understanding the complicated cytokine networks involved in RV infection may be necessary. Therefore, the complexity of RV-induced asthma is not only owing to the response of airway and immune cells against viral infection, but also to allergic immune responses caused by the wide variety of cytokines produced by these cells. To better understand RV-induced asthma, it is necessary to elucidate the nature RV infections and the corresponding host defence mechanisms. In this review, we attempt to organise the complexity of RV-induced asthma to make it easily understandable for readers.
African Swine Fever Modified Live Vaccine Candidates: Transitioning from Discovery to Product Development through Harmonized Standards and Guidelines
Authors: Brake David A.
Published: November 2022

The recent centennial anniversary of R.E. Montgomery’s seminal published description of “a form of swine fever” disease transmitted from wild African pigs to European domestic pigs is a call to action to accelerate African Swine Fever (ASF) vaccine research and development. ASF modified live virus (MLV) first-generation gene deleted vaccine candidates currently offer the most promise to meet international and national guidelines and regulatory requirements for veterinary product licensure and market authorization. A major, rate-limiting impediment to the acceleration of current as well as future vaccine candidates into regulatory development is the absence of internationally harmonized standards for assessing vaccine purity, potency, safety, and efficacy. This review summarizes the asymmetrical landscape of peer-reviewed published literature on ASF MLV vaccine approaches and lead candidates, primarily studied to date in the research laboratory in proof-of-concept or early feasibility clinical safety and efficacy studies. Initial recommendations are offered toward eventual consensus of international harmonized guidelines and standards for ASF MLV vaccine purity, potency, safety, and efficacy. To help ensure the successful regulatory development and approval of ASF MLV first generation vaccines by national regulatory associated government agencies, the World Organisation for Animal Health (WOAH) establishment and publication of harmonized international guidelines is paramount.
Hospitalization and Mortality by Vaccination Status among COVID-19 Patients Aged ≥ 25 Years in Bangladesh: Results from a Multicenter Cross-Sectional Study
Authors: Rahman Md. Saydur , Harun Md. Golam Dostogir , Sumon Shariful Amin , Mohona Tahrima Mohsin , Abdullah Syed Abul Hassan Md , Khan Md. Nazuml Huda , Gazi Md. Ismail , Islam Md. Saiful , Anwar Md. Mahabub Ul
Published: November 2022

The COVID-19 pandemic has inflicted a massive disease burden globally, involving 623 million confirmed cases with 6.55 million deaths, and in Bangladesh, over 2.02 million clinically confirmed cases of COVID-19, with 29,371 deaths, have been reported. Evidence showed that vaccines significantly reduced infection, severity, and mortality across a wide age range of populations. This study investigated the hospitalization and mortality by vaccination status among COVID-19 patients in Bangladesh and identified the vaccine’s effectiveness against severe outcomes in real-world settings. Between August and December 2021, we conducted this cross-sectional survey among 783 RT-PCR-confirmed COVID-19 hospitalized patients admitted to three dedicated COVID-19 hospitals in Bangladesh. The study used a semi-structured questionnaire to collect information. We reviewed the patient’s records and gathered COVID-19 immunization status from the study participants or their caregivers. Patients with incomplete or partial data from the record were excluded from enrollment. Logistic regression analyses were performed to determine the association between key variables with a patient’s vaccination status and mortality. The study revealed that overall hospitalization, severity, and morality were significantly high among unvaccinated study participants. Only one-fourth (25%) of hospitalized patients were found COVID-19 vaccinated. Morality among unvaccinated COVID-19 study participants was significantly higher (AOR: 7.17) than the vaccinated (11.17% vs. 1.53%). Severity was found to be seven times higher among unvaccinated patients. Vaccination coverage was higher in urban areas (29.8%) compared to rural parts (20.8%), and vaccine uptake was lower among female study participants (22.7%) than male (27.6%). The study highlighted the importance of COVID-19 vaccines in reducing mortality, hospitalization, and other severe consequences. We found a gap in vaccination coverage between urban and rural settings. The findings would encourage the entire population toward immunization and aid the policymakers in the ground reality so that more initiatives are taken to improve vaccination coverage among the pocket population.
Awareness, Acceptance, and Associated Factors of Human Papillomavirus Vaccine among Parents of Daughters in Hadiya Zone, Southern Ethiopia: A Cross-Sectional Study
Authors: Larebo Yilma Markos , Elilo Legesse Tesfaye , Abame Desta Erkalo , Akiso Denebo Ersulo , Bawore Solomon Gebre , Anshebo Abebe Alemu , Gopalan Natarajan
Published: November 2022

Introduction: Human papillomavirus infections are the most prevalent sexually transmitted disease among women worldwide. Cervical cancer is the second-most frequent disease worldwide in terms of incidence and mortality, and it is primarily responsible for fatalities in low- to middle-income nations, including Ethiopia. Objective: To assess awareness, acceptance, and associated factors of the human papillomavirus vaccine among parents of daughters in the Hadiya zone, southern Ethiopia. Methods: From November to December 2021, a community-based cross-sectional study was conducted in the Hadiya zone among parents with daughters in the zone. The study respondents were chosen using a two-stage sampling technique from parents with a 9–14-year-old daughter. An interviewer-administered questionnaire was used to collect data. For analysis, the data were entered into Epidata version 3.1 and exported to SPSS version 25. Variables with a p-value less than 0.25 in the bivariate analysis were transferred to multivariable analysis. A logistic regression model was applied to forecast the association between the predictor and outcome variables. Statistical significance was considered at a 0.05 p-value. Results: The study showed that the overall acceptance of parents to vaccinate their daughters with HPV vaccination was 450 (84.9%). Parents of daughters of male sex (AOR: 0.407; 95%CI: 0.221, 0.748), who had only one daughter (AOR: 2.122; 95%CI: 1.221, 3.685), whose daughter(s) attended a government school (AOR: 0.476; 95%CI: 0.263, 0.861), who had poor knowledge (AOR: 0.532; 95%CI: 0.293, 0.969) and who had a negative attitude (AOR: 0.540; 95%CI: 0.299, 0.977) were discovered to have a strong correlation. Conclusion: This study found that there was a high level of parental acceptance; attitudes and knowledge about the HPV vaccine are significant in determining their intentions to vaccinate their daughter. Authorities in high-risk areas for cervical cancer incidence should plan and implement strategies by providing health information regarding human papillomavirus vaccination with an emphasis on raising community awareness.
Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
Authors: Abu-Raya Bahaa , Forsyth Kevin , Halperin Scott A. , Maertens Kirsten , Jones Christine E. , Heininger Ulrich , Hozbor Daniela , Wirsing von König Carl Heinz , Chitkara Amar J. , Muloiwa Rudzani , Tan Tina Q.
Published: November 2022

Infants are at high risk for severe morbidity and mortality from pertussis disease during early infancy. Vaccination against pertussis in pregnancy has emerged as the ideal strategy to protect infants during these early, vulnerable, first months of life. On 30 November and 1 December 2021, the Global Pertussis Initiative held a meeting that aimed to discuss and review the most up-to-date scientific literature supporting vaccination against pertussis in pregnancy and outstanding scientific questions. Herein, we review the current and historically published literature and summarize the findings as consensus statements on vaccination against pertussis in pregnancy on behalf of the Global Pertussis Initiative.
Recombinant African Swine Fever Virus Arm/07/CBM/c2 Lacking CD2v and A238L Is Attenuated and Protects Pigs against Virulent Korean Paju Strain
Authors: Pérez-Núñez Daniel , Sunwoo Sun-Young , García-Belmonte Raquel , Kim Chansong , Vigara-Astillero Gonzalo , Riera Elena , Kim Dae-min , Jeong Jiyun , Tark Dongseob , Ko Young-Seung , You Young-Kook , Revilla Yolanda
Published: November 2022

African swine fever (ASF) is an obligated declaration swine disease, provoking farm isolation measures and the closing of affected country boarders. ASF virus (ASFV) is currently the cause of a pandemic across China and Eurasia. By the end of 2019, ASF was detected in nine EU Member States: Bulgaria, Romania, Slovakia, Estonia, Hungary, Latvia, Lithuania, Poland and Belgium. The affected area of the EU extended progressively, moving mostly in a southwestern direction (EFSA). Inactivated and/or subunit vaccines have proven to fail since certain virus replication is needed for protection. LAVs are thus the most realistic option, which must be safe, effective and industrially scalable. We here generated a vaccine prototype from the Arm/07/CBM/c2 genotype II strain, in which we have deleted the EP402R (CD2v) and A238L genes by CRISPR/Cas9 in COS-1 cells, without detectable further genetic changes. The successful immunization of pigs has proven this vaccine to be safe and fully protective against the circulating Korean Paju genotype II strain, opening the possibility of a new vaccine on the market in the near future.
Childhood Influenza Vaccination and Its Determinants during 2020–2021 Flu Seasons in China: A Cross-Sectional Survey
Authors: Han Kaiyi , Hou Zhiyuan , Tu Shiyi , Wang Qian , Hu Simeng , Xing Yuting , Du Jing , Zang Shujie , Chantler Tracey , Larson Heidi
Published: November 2022

Young children aged 6–59 months are recommended as one of the priority groups for seasonal influenza vaccination in China. This study assessed influenza vaccination coverage and the factors associated with vaccination uptake among children in three Chinese provinces. In September 2021, 2081 caregivers with children <5 years completed self-administered questionnaires as part of a cross-sectional survey. Logistic regression was used to assess determinants of childhood influenza vaccination. A total of 43.63% of respondents reported vaccinating their children against influenza during the 2020–2021 flu season. Caregivers who lived in Anhui province, had a bachelor degree or above, and an annual household income <20,000 RMB were more likely to vaccinate their children against influenza. Confidence in the importance (OR: 2.50; 95%CI: 1.77–3.54), safety (OR: 1.60; 95%CI: 1.29–1.99), and effectiveness (OR: 1.54; 95%CI: 1.23–1.93) of influenza vaccine was significantly associated with childhood vaccine acceptance. Respondents who saw that other caregivers were vaccinating their children had significantly higher odds of vaccinating their own children. Caregivers’ receiving positive influence from healthcare workers (OR: 1.33; 95%CI: 1.00–1.77), family members, or friends (OR: 1.30; 95%CI: 1.14–1.49) were also significantly associated with childhood influenza vaccination. Poor access, including conflicts between caregivers’ availability and vaccination service schedules and inconvenient transportation to the vaccination site were negatively associated with childhood flu vaccination. To promote childhood influenza vaccination, public health information campaigns need to target wealthier and less educated caregivers to enhance caregivers’ confidence in influenza vaccination. Targeted interventions are also needed to optimize access to vaccination services, including extending vaccination service hours and increasing the number of vaccination sites close to residential areas. Interventions are also needed to encourage primary care providers to play a greater role in promoting vaccination. Finally, the dissemination of related information and the public response need to be monitored for the timely understanding of public perceptions.
Immunogenicity and Efficacy of Monovalent and Bivalent Formulations of a Virus-Like Particle Vaccine against SARS-CoV-2
Authors: Resch Matthew D. , Wen Ke , Mazboudi Ryan , Mulhall Maasz Hannah , Persaud Mirjana , Garvey Kaitlyn , Gallardo Leslie , Gottlieb Paul , Alimova Aleksandra , Khayat Reza , Morales Jorge , Bielefeldt-Ohmann Helle , Bowen Richard A. , Galarza Jose M.
Published: November 2022

Virus-like particles (VLPs) offer great potential as a safe and effective vaccine platform against SARS-CoV-2, the causative agent of COVID-19. Here, we show that SARS-CoV-2 VLPs can be generated by expression of the four viral structural proteins in a mammalian expression system. Immunization of mice with a monovalent VLP vaccine elicited a potent humoral response, showing neutralizing activity against multiple variants of SARS-CoV-2. Subsequent immunogenicity and efficacy studies were performed in the Golden Syrian hamster model, which closely resembles the pathology and progression of COVID-19 in humans. Hamsters immunized with a bivalent VLP vaccine were significantly protected from infection with the Beta or Delta variant of SARS-CoV-2. Vaccinated hamsters showed reduced viral load, shedding, replication, and pathology in the respiratory tract. Immunized hamsters also showed variable levels of cross-neutralizing activity against the Omicron variant. Overall, the VLP vaccine elicited robust protective efficacy against SARS-CoV-2. These promising results warrant further study of multivalent VLP vaccines in Phase I clinical trials in humans.
On the Collaborative Use of EV Charging Infrastructures in the Context of Commercial Real Estate
Authors: Gauss Joela , Gohlke Sascha , Nochta Zoltán
Published: November 2022

Resource sharing in general is a means of solving the problem of infrequent and, thus, inefficient utilization of expensive or scarce resources. In this paper, we present an approach to run shared EV-charging infrastructures in the context of commercial real-estate facilities. Collaborating EV-charger owners thereby create a pool of chargers for shared use. In our work, we consider aspects of economic viability, desirability and technical feasibility as prerequisites of a successful solution. We formally prove that the basic economic potential of the proposed pooling with regard to overall infrastructure utilization is given. In order to operate the shared pool of charging points at a given location, the corresponding management software must fulfil specific requirements. Our prototype implementation that was realized as an extension of the open-source system Open E-Mobility demonstrates the technical feasibility of the sharing idea in a user-friendly way. Questionnaires and personal interviews conducted with owners of small and medium-sized businesses revealed that they would share charging stations if it helped overcome availability bottlenecks, thus improving customer and employee perception.
Self-Efficacy, Perceived Stress, and Individual Adjustment among College-Attending Emerging Adults
Authors: Madson Rebecca C. , Perrone Paula B. , Goldstein Sara E. , Lee Chih-Yuan Steven
Published: November 2022

In a large, ethnically diverse sample of college-attending emerging adults (N = 693; ages 18–29), the current study examines associations between self-efficacy and individual adjustment (academic satisfaction, depressive symptoms, subjective physical health, and loneliness), directly and indirectly through perceived stress. Moderated mediation effects by sex, ethnicity, school year, and first-generation status were also explored. Using PROCESS, results show that self-efficacy was directly related to adjustment, and indirectly related through lower stress. Sex moderated the associations between self-efficacy and stress as well as stress and depressive symptoms; the relations were stronger in women. School year moderated how stress was associated with academic satisfaction in that the negative association was not found among the fourth-year students, but in all other peers. First-generation status moderated the negative association of self-efficacy and stress, with it being greater for first-generation college students compared to their peers. In addition, self-efficacy was positively related to academic satisfaction for first-generation students, but no relation was found for other students.
Efficacy of low-intensity laser therapy in rhinosurgery patients
Authors:   FSBEI HE Ivanovo State Medical Academy, Volkovskaya A.N. , Zhaburina M.V. ,   FSBEI HE Ivanovo State Medical Academy, Borzov E.V. ,   FSBEI HE Ivanovo State Medical Academy
Published: November 2022

The efficiency indicators of low-intensity laser therapy in patients with a combination of deviated septum and vasomotor rhinitis in the postoperative period were studied. The analysis was carried out in the groups with favorable and unfavorable courses. The features of the use of low-intensity laser radiation for faster restoration of nasal functions and improvement of the postoperative course were established.
Differential diagnosis of malaria and hemolytic anemia
Authors:   Clinical Infectious Diseases Hospital named after S. P. Botkin, St. Petersburg, Ilyin P. A.
Published: November 2022

A correct diagnosis is the basis for a correct treatment. In clinical practice, it happens sometimes that the diagnosis seems in no doubt. However, experience shows that misdiagnosis is not uncommon. Even when it seems of a certainty. Malaria is a group of vector-borne infectious diseases transmitted to humans through the bites of female Anopheles mosquitoes, infected by parasitic protists of the genus Plasmodium, predominantly Plasmodium falciparum. Malaria is accompanied by fever, chills, splenomegaly, hepatomegaly, and anemia. It is characterized by a chronic relapsing course. Hemolytic anemia is a group name for rare diseases, a common symptom of which is an increased destruction of red blood cells, causing, on the one hand, anemia and increased formation of erythrocyte decay products, and on the other hand, reactively enhanced erythropoiesis.
Description of a clinical case of cervicogenic headache with anomalies in the development of the nuchal ligament
Authors:   FSBI «52nd Consultative and Diagnostic Center» of the Ministry of Defense of the Russian Federation, Russian Federation, Ryzhova E. E. , Sysoev A. V. ,   FSBI «52nd Consultative and Diagnostic Center» of the Ministry of Defense of the Russian Federation, Russian Federation, Mansur T. I. ,   Medical Institute, Peoples’ Friendship University of Russia, Suvorova N.N. ,   Consultative and Diagnostic Center No. 6 of the Moscow Healthcare Department
Published: November 2022

The article describes a case of diagnosis and treatment of one of the varieties of cervicogenic headache caused by the nuchal ligament hypertrophy. Anomaly in the development of this ligament in the form of its pronounced compaction and shortening caused pathological afferentation both from the structures of the ligament itself and from the area of its attachment to the skull bone structures and, as a result, the development of persistent cranialgia. The article also describes a method of treatment by manual impact on the hypertrophied nuchal ligament, as a result of which a good clinical effect is achieved.
Consumo de hierbas medicinales para aliviar síntomas de afecciones respiratorias y COVID-19
Authors: Legua Cárdenas José Antonio , More López Jesús Manuel , Yovera Saldarriaga José , Ccaira Mamani Cirilo Mario , Cherrepano Manrique Reynaldo Francisco , Caro Soto Félix Gil , Jamanca Ramirez Marco Antonio
Published: November 2022

Con el brote de COVID-19, se incrementó el consumo de plantas medicinales a raíz de su fácil, económica disponibilidad y conocimientos empíricos de sus propiedades medicinales y efectos terapéuticos para algunas enfermedades. Esta realidad de consumo de hierbas medicinales para aliviar síntomas de afecciones respiratorias y COVID-19, motivó la presente investigación. Objetivo. Determinar el grado de asociación entre el consumo de hierbas medicinales y su efecto en alivio de síntomas del virus. Materiales y método. La metodología se basa en estudio descriptivo, enfoque cuantitativo, prospectivo. Se recolectó los datos desde febrero hasta mayo del 2021 con una muestra de 400 personas que comprendió ambos sexos. Se encuestó sobre ¿Qué hierbas medicinales consumieron en forma de infusión? y ¿Con qué frecuencia consumen para aliviar los síntomas relacionados a afecciones respiratorias y COVID-19? Resultados. Los resultados determinaron que las hierbas medicinales de mayor consumo fueron Matico (Buddleja globosa), Eucalipto (Eucalyptus globulus), Escorzonera (Perezia multiflora) y Huamanripa (Senecio tephrosioides); con una frecuencia de 2 a 3 veces por día y 4 o 5 días por semana; marzo se obtuvo 3% consumo de Huamanripa y mayo 6% de hierbas combinada para afecciones respiratorias y COVID-19 respectivamente, febrero con 29% para afecciones respiratorias y mayo con 73% para dolencias del COVID-19. Sintieron alivio al ingerir infusiones de hierbas medicinales en mayo con 79% y coeficiente de determinación de 0.9984 que indica una alta asociación. Conclusiones. Al analizar los datos entre consumo de hierbas medicinales y alivio de síntomas de COVID-19, se obtuvo una alta correlación; por lo tanto, indica que alivia los síntomas.
L’apport antiesclavagiste de Pechméjà et de Diderot à l’Histoire des deux Indes
Authors: Biondi Carminella
Published: November 2022

À travers une analyse ponctuelle du livre XI de l’Histoire des deux Indes

en 1770 et de sa réécriture en 1780, l’article s’attache à évaluer les apports de Pechméja et de Diderot dans ces oeuvres, apports qui ont contribué à en faire, malgré de nombreuses contradictions, une «machine de guerre » contre l’esclavage. Le résultat est tout à fait exceptionnel parmi les ouvrages entièrement consacrés à la colonisation européenne, qui s’attachent le plus souvent aux fastes de cette colonisation. Diderot et Pechméja ont écrit, mais c’est Raynal qui a signé : à chacun son rôle dans cette entreprise extraordinaire, et peu importe si Raynal a plus tard pris ses distances vis-à-vis de sa création protéiforme, en particulier sur le problème de l’esclavage des Noirs. La flèche avait été lancée.
Les stations navales françaises en Amérique méridionale sous la Restauration
Authors: Gutiérrez Ardila Daniel
Published: November 2022

Le refus français d’établir des relations diplomatiques avec les nouveaux États de l’Amérique espagnole a conféré, pendant la troisième décennie du XIXe siècle, un rôle fondamental aux commandants des stations navales des Antilles et du Brésil pour ce qui concerne la découverte et la gestion de la nouvelle réalité politique hispano-américaine. Les instructions reçues du ministère de la Marine et des Colonies leur donnent pour mission, non seulement la protection du commerce et l’inspection des principaux ports des jeunes États indépendants, mais encore la prise de contact avec les nouvelles autorités et la rédaction de rapports détaillés éclairant Paris sur la nature et l’irréversibilité des changements politiques. Leur rôle s’avère donc fondamental pour qui étudie les processus révolutionnaires et s’intéresse à la période des Restaurations. Quel était à l’époque l’engagement des autres puissances dans les mers du sous-continent ? Quel était le profil politique des commandants des stations navales françaises dans l’Amérique méridionale ? Comment les forces maritimes du royaume ont-elles évolué tout au long de la période ? Enfin, la France a-t-elle envisagé la possibilité d’acquérir de nouvelles colonies à l’occasion de l’effondrement de l’empire espagnol ? Telles seront les principales questions analysées dans cet article.
La función de las didascalias en la indicación de las causas de la enunciación dramática
Authors: Zucchi Mariano
Published: November 2022

El discurso didascálico constituye uno de los componentes del texto dramático más estudiado en el campo de la teatrología. Sin embargo, no existe en la actualidad un consenso respecto a los atributos lingüísticos de estos enunciados ni a su función en el proceso de construcción de sentido. Mediante la utilización como marco teórico del Enfoque dialógico de la argumentación y la polifonía enunciativa (Caldiz 2019; García Negroni 2019; 2021; García Negroni y Libenson 2018), este artículo se propone estudiar el funcionamiento semántico-enunciativo de las didascalias particulares: expresiones escritas entre paréntesis que acompañan las réplicas de los personajes. En particular, en este trabajo se analizan aquellos casos en los que las didascalias inciden en la determinación de las indicaciones causales, i.e., los señalamientos que todo enunciado porta sobre los motivos de su irrupción. Para ello, se toma como corpus didascalias presentes en textos que responden a distintas estéticas teatrales (Albee [1962] 2000; Arlt [1938] 1993; Beckett [1952] 2013; Camus [1944] 2004; Casona [1943] 1985 y Miller [1949] 2013) y se explica su injerencia en la construcción de sentido. Específicamente, se pretende mostrar que las didascalias particulares en algunas oportunidades instan a recuperar un marco de discurso que se presenta como la causa que desencadena la enunciación del personaje y justifica las propiedades que esta reviste.
Reseña de 101 preguntas para ser profe de ELE. Introducción a la lingüística aplicada para la enseñanza del español
Authors: Torres Lola
Published: November 2022

Aprender un idioma es un proceso que conlleva tiempo, práctica, formación y reflexión. Aprender a ser profesor de idiomas también. Este camino supone una experiencia única, indispensable y personal pero que, sin duda, puede enriquecerse notablemente si se acompaña de una guía como 101 preguntas para ser profe de ELE. Introducción a la lingüística aplicada para la enseñanza del español, de María Méndez Santos. Se trata de un completo manual dirigido a profesores que estén iniciando su formación en la enseñanza del español, pero también resulta útil para docentes con experiencia que quieran actualizarse y contar con una guía de referencia a la hora de revisar prácticas y aprender de ellas.
Supercomputing-based cybersecurity event analytical processing system: construction conception
Authors:   St. Petersburg Institute for Informatics and automation of the Russian Academy of Sciences, Kotenko I.V. , Saenko I.B. , Kochin V.P.
Published: November 2022

The growth in the volume of collected data on cybersecurity events and the development of methods and tools for their reliable storage leads to an increase in the relevance of developing new methods and algorithms for analyzing large and ultra-large data sets of this class. The paper examines the concept of building the supercomputing-based cybersecurity event analytical processing system, produced in the interests of state assessment, decision support and investigation of computer incidents in critical infrastructures. Approaches to the application of supercomputing to large cybersecurity data processing have been analyzed. The architecture of a system for analytical processing of heterogeneous cybersecurity event data based on supercomputing has been proposed and discussed.
An algorithm for automating the process of forming and processing applications for an increased academic scholarship for achievements in research activities
Authors:   Reshetnev Siberian State University of Science and Technology, Ognegina P.S. , Ognegin K.E. , Popov A.A.
Published: November 2022

The article presents the results of the development of an algorithm for automating the process of forming and processing applications for PGAS for achievements in research activities. The task of automating the process of forming and processing applications for PGAS for achievements in research activities is being solved. The article considers only scientific publications of students as achievements.
Algorithms for assessing the security of the human-computer interface
Authors:   St. Petersburg Federal Research Center of the Russian Academy of Sciences, Zhernova K.N. , Chechulin A.A.
Published: November 2022

Computer technologies affect almost all branches of human activity. For this reason, the problem of assessing the quality of interaction between the operator and the system is relevant. The quality of the human-computer interface is most often understood as the usability. However, sensitive data may be transferred from the operator to the system, which cannot be provided to a third party. For this reason, it is required to evaluate the security of the operator’s interaction with the interface. Currently, there are no works on evaluating the security of human-computer interfaces. This paper presents algorithms for assessing the security of a human-computer interface.
Pengaruh Kepemimpinan, Lingkungan Kerja dan Konpensasi Terhadap Kinerja Dosen dengan Motivasi debagai Variabel Intervening di STKIP Widyaswara Indonesia
Authors: Adrika Putra Mandra , Zefriyenni  , Lusiana
Published: November 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis : Pengaruh kepemimpinan, lingkungan kerja dan kompensasi terhadap peningkatan kinerja Dosen pada STKIP Widyaswara Indonesia. Pengaruh kepemimpinan, lingkungan kerja dan kompensasi terhadap peningkatan motivasi Dosen pada STKIP Widyaswara Indonesia. Pengaruh motivasi terhadap peningkatan kinerja Dosen pada STKIP Widyaswara Indonesia. Pengaruh kepemimpinan, Lingkungan kerja dan kompensasi terhadap kinerja Dosen pada STKIP Widyaswara Indonesia melalui motivasi sebagai variabel intervening. Penelitian ini dilakukan dengan menggunakan desain penelitian deskriptif dan kausal dan sampel diambil dengan rancangan sampel non probability silling dengan teknik pengambilan porposive sampling, Pada penelitian ini jumlah populasi sebanyak 31 orang. Sedangkan instrumen penelitian ini berupa kuesioner dengan menggunkan skala likert.Teknik analisis data pada penelitian ini menggunakan analisi Structural Equation Modeling (SEM) Hasil penelitian menunjukkan bahwa kepemimpinan tidak berpengatuh signifikan terhadap motivasi kerja dosen, sedangakan lingkungan kerja dan kompensasi berpengaruh signifikan terhadap motivasi kerja dosen. Kepemimpinan, lingkungan kerja dan kompensasi tidak berpengaruh signifikan terhadap kinerja dosen. Motivasi berpengaruh signifikan terhadap kinerja dosen. Kepemimpinan tidak berpengaruh signifikan terhadap kinerja dosen melalui motivasi, sedangkan lingkungan kerja dan kompensasi berpengaruh signifikan terhadap kinerja dosen melalui motivasi
Syndrome inflammatoire multisystémique pédiatrique (PIMS-TS) – aspects cardiologiques
Authors: Wütz Daniela , Bressieux-Degueldre Sabrina
Published: November 2022

Le syndrome inflammatoire multisystémique pédiatrique (Paediatric inflammatory multisystem syndrome temporally associated with SARS-Cov-2, PIMS-TS) est une complication rare de l’infection SARS CoV-2 chez l’enfant (<1%). Des manifestations cardiologiques, avec dysfonction ventriculaire pouvant engendrer un choc cardiovasculaire, des troubles du rythme et le développement d’anévrismes coronaires, surviennent dans 80-85% des cas.
“Instituciones, agentes y proyectos para el saber agropecuario entre fines del siglo XIX y la revolución verde en Argentina”
Authors: Rodríguez Vázquez Florencia , Martocci Federico
Published: November 2022

Los procesos e iniciativas para “racionalizar”, “modernizar” y/o “tecnificar” el agro latinoamericano conjugaron el esfuerzo de instituciones estatales, y también de actores privados, desde finales del siglo XIX (Weinberg, 1998). Dichas temáticas concitaron el interés de la historiografía en diferentes países entre las postrimerías del siglo XX y lo que va del XXI, tal como ejemplifican la publicación de obras individuales y colectivas de largo aliento, y recientes dossiers en revistas científicas.

Argentina no permaneció ajena a esa tendencia. Inicialmente, es posible detectar el aporte central del Departamento de Agricultura (DA, 1871), luego convertido en Ministerio de Agricultura (MAN,1898), que diseñó políticas sectoriales para fomentar el desarrollo agropecuario en las diversas regiones que componen el país y tuvo un desempeño significativo durante la última parte del siglo XIX y la primera mitad del XX (Djenderedjian, 2014 b y 2019).
PENGARUH WORD OF MOUTH DAN SERVICESCAPE TERHADAP KEPUTUSAN PEMBELIAN
Authors: Moenardy Khalid K , Winarni Fajar Shavira Cahya
Published: November 2022

This study aims to determine the effect of Word Of Mouth and Servicescape on purchasing decisions at dr. Maharani Kupang Skin Care. The independent variables in this study are Word Of Mouth and Servicescape, while the dependent variable is Purchasing Decisions. The number of samples in this study were 80 respondents, namely all active customers of dr. Maharani Skin Care in Kupang. Samples were obtained by using accidental sampling technique. The data analysis technique is Descriptive Quantitative, Multiple Linear Regression Analysis and hypothesis testing using the SPSS version 26. The results of the descriptive analysis show that overall the respondents gave a very good perception of Word Of Mouth and servicescape to dr. Maharani Skin Care in Kupang. Both the results of the t test and the F test show that simultaneously and partially Word Of Mouth and Servicescape have a significant influence on Purchasing Decisions. Based on the Adjusted R2 value, it shows the contribution of Word Of Mouth and Servicescape to Purchasing Decisions is 54.7%  while 45.3% is influenced by other variables outside the focus of this study. Other variables are Product Quality, Price, Promotion and Service Quality which can be taken into consideration for further researchers in addition to Word Of Mouth and Servicescape.

Keywords: Word Of Mouth, Servicescape, Purchasing Decision
THE IMPACT OF TAX AVOIDANCE AND AUDIT QUALITY ON TAX AMNESTY PROGRAM
Authors: Pangaribuan David , Marundha Amor , Mulyadi Mulyadi
Published: November 2022

Purpose this study was to examine the effect of tax avoidance and audit quality on companies participating in tax amnesty based on Law no. 11 of 2016 concerning Tax Amnesty. Data processing uses logistic regression. Results of study found that companies with high audit quality have a lower participating in tax amnesty. Regression results showed that the tax avoidance has no effect on companies participating in tax amnesty. Implication of the research is as initial information for government as a tax regulator in taking or formulating policies related to tax amnesty. One of conditions for receiving tax amnesty is companies regularly report their tax payments.

Keywords: Tax Amnesty, Tax Avoidance, Audit Quality, Big Four
REVENUE FROM REGENCY/CITY REGIONAL TAX AND RETRIBUTION SHARING TO SUPPORT THE PERFORMANCE OF THE KRAGAN VILLAGE GOVERNMENT IN EAST JAVA PROVINCE
Authors: Suyanto Suyanto , Warjiyati Sri
Published: November 2022

Purpose of this study is to analyze the effects of local taxes and retribution in influencing the performance of the Kragan village government in East Java Province. Methodology is a quantitative approach. The analyzed data sources is the Human Development Index (HDI) obtained from the Central Bureau of Statistics. While the data used are cross sectional and time series taken from 2015 - 2020. Study findings revealed that regional tax revenues increase in regional taxes, the more various activities that can be funded with local taxes. Thus it will also have a positive impact on the performance of the village government in implementing regional autonomy which aims to improve the welfare of the community. Limitations in this study is related to tax management in the region. Suggestions for the Kragan village government in East Java Province are to supervise the implementation and collection of regional taxes and retribution. So that both can be used in improving the welfare of the community. Future researchers may ensure the completeness of data sources and uniformity of methods from the data used.

Keywords: Regions, Retribution, Taxes, Welfare
PENGARUH PERSEPSI HARGA DAN LOKASI USAHA TERHADAP MINAT BELI KONSUMEN PADA PRODUK BUKET DI KECAMATAN SEBERANG ULU II KOTA PALEMBANG
Authors: Susanti Ayu , Rismansyah Rismansyah , Robyardi Erfan
Published: November 2022

This study aims to determine the effect of Price Perception and Business Location on Consumer Buying Interest in bouquet products in Seberang Ulu II District, Palembang City. The research method used in this study is a quantitative method with a sample of 97 respondents. The data analysis technique is Multiple Linear Regression Analysis, Correlation Coefficient Analysis and Coefficient of Determination Analysis using SPSS statistical software version 21.The results of the analysis show that: 1) Price Perception has a significant effect on Consumer Buying Interest in bouquet products in Seberang Ulu II District, Palembang City; 2) Business Location has a significant effect on Consumer Buying Interest in bouquet products in Seberang Ulu II District, Palembang City; 3) Price Perception and Business Location have a significant effect simultaneously on Consumer Buying Interest in bouquet products in Seberang Ulu II District, Palembang City. Based on Adjusted R2, it shows that the contribution given by the Price Perception and Business Location to Consumer Buying Interest is 57.9% and the remaining 42.1% is influenced by other factors that not included in this study. Further researchers should add other variables that can increase consumer buying interest such as Promotion and Product Quality.

Keywords: Price Perception, Business Location, Consumer Buying Interest
Tradisi Perahu Bidar sebagai Warisan Budaya dalam Kehidupan Masyarakat Kota Palembang
Authors: Elfarissyah Andriamella , Attas Siti Gomo
Published: November 2022

Tradisi Perahu Bidar adalah salah satu warisan budaya pada masyarakat kota Palembang yang patut untuk dilestarikan. Keberadaan perlombaan perahu bidar selalu dinantikan oleh masyarakat Palembang, karena tradisi ini memiliki nilai-nilai kehidupan bagi masyarakat kota Palembang yang dikenal sebagai wilayah maritim. Tujuan dari penelitian ini adalah untuk mengetahui sejarah tradisi perahu bidar di Sungai Musi dan upaya-upaya yang dilakukan oleh pemerintah dan masyarakat dalam melestarikan tradisi bidar sebagai warisan budaya pada masyarakat Palembang. Penelitian ini menggunakan pendekatan kualitatif, data-data penelitian didapat melalui wawancara, observasi dan tinjauan pustaka. Peneliti mendeskripsikan tentang sejarah tradisi perahu bidar sebagai warisan budaya dan upaya-upaya pemerintah dan masyarakat dalam melestarikan tradisi perahu bidar disungai musi. Penelitian ini kedapannya diharapkan sebagai bukti bahwa adanya kaitan antara perlombaan tradisi bidar ini sebagai warisan budaya leluhur yang harus dilestarikan sehingga bisa diteruskan oleh generasi selanjutnya pada masyarakat kota Palembang.
Tingkat Minat Siswa dalam Mengikuti Ekstrakurikuler Futsal di SMAN 1 Pagaden Subang
Authors: Hakim Muhamad Reza Nur , Ismaya Bambang , Achmad Irfan Zinat
Published: November 2022

Tujuan penelitian yaitu untuk mengetahui berapa besar minat siswa terhadap kegiatan ekstrakurikuler futsal pada Siswa SMA Negeri 1 Pagaden Subang. Jenis penelitian ini adalah penelitian deskriktif. Populasi penelitian ini adalah siswa SMA Negeri 1 Pagaden Subang kelas yang memiliki tingkat usia yang sama yaitu 14-17 tahun. Populasi dan pengambilan sampel yaitu menggunkan teknik purposive dengan karakteristik orang-orang yang bermain futsal. Teknik analisis data deskriktif dengan perhitungan dalam angket. Berdasarkan hasil analisis diskriktif menunjukkan bahwa rata-rata minat siswa dalam bermain futsal berada pada kategori rendah. Hal ini terlihat baik pada faktor internal maupun faktor eksternal siswa SMA Negeri 1 Pagaden Subang.