bluuebunny/crossref_metadata_2025 huggingface dataset:
Maternal satisfaction with reduced postnatal length of stay in Brussels: evidence from the KOZI&Home program
Authors: Stas Amber , Breugelmans Maria , Geerinck Lynn , Spinnoy An , Van Laere Sven , Gucciardo Leonardo , Laubach Monika , Faron Gilles , Beeckman Katrien
Published: June 2023

Background

Reducing the length of stay (LOS) after childbirth is a trend, including cost savings, a more family-centered approach and lower risk for nosocomial infection. Evaluating the impact of reduced LOS is important to improve the outcomes of care, which include maternal satisfaction. The aim of this study was to compare the maternal satisfaction, before and after the reduced LOS.

Methods

This study was conducted in the University Hospital Brussels, before and after implementing the KOZI&Home program (intervention). This KOZI&Home program consisted of a reduced length of stay of at least one day for both vaginal delivery and caesarean section. It also included three extra antenatal visits with the midwife, preparing for discharge and postnatal home care by an independent midwife. Women completed a questionnaire, including the Maternity Satisfaction Questionnaire (MSQ) and Home Satisfaction Questionnaire (HSQ), respectively at discharge and two weeks postpartum. Satisfaction was split into five dimensions: ‘Midwives time investment’, ‘Provision of information’, ‘Physical environment’, ‘Privacy’ and ‘Readiness for discharge’. A combination of forward and backward model selection (both directions) was used for statistical analysis.

Results

In total, 585 women were included in this study. 332 women in the non-intervention group and 253 women in the intervention group. Satisfaction with ‘provision of information’ at home had a higher mean score of 4.47/5 in the intervention group versus 4.08/5 in the non-intervention group (p < 0.001). Women in the KOZI&Home group were more satisfied regarding ‘privacy at home’ (mean 4.74/5 versus 4.48/5) (p < 0.001) and ‘readiness for discharge’ (p = 0.02).

Conclusion

The intervention was associated with a higher score in some of dimensions of satisfaction. Our study concludes that this integrated care program is acceptable for postpartum women and associated with some favourable outcomes.
Relationships among autistic traits, depression, anxiety, and maternal–infant bonding in postpartum women
Authors: Fukui Naoki , Watanabe Yuichiro , Motegi Takaharu , Hashijiri Koyo , Ogawa Maki , Egawa Jun , Enomoto Takayuki , Someya Toshiyuki
Published: June 2023

Background

Although several studies have found significant relationships between autistic traits and depression/anxiety, the relationships between autistic traits and postpartum depression/anxiety remain unclear. Moreover, few studies have examined the relationships between autistic traits and mother–infant bonding while considering depression or anxiety.

Methods

This study used a cross-sectional data analysis design. Participants were 2692 women who completed the Autism-Spectrum Quotient (AQ), Hospital Anxiety and Depression Scale (HADS), and Mother-to-Infant Bonding Scale (MIBS) at 1 month postpartum. We performed path analysis that included parity, the five AQ subscales (social skills, attention switching, attention to detail, communication, and imagination), both HADS subscales (anxiety and depression), and the two MIBS subscales (lack of affection and anger and rejection).

Results

Our path analysis revealed that higher scores for social skills, attention switching, communication, and imagination were associated with higher scores for depression. Higher scores for social skills, attention switching, attention to detail, and communication were associated with higher scores for anxiety. Moreover, difficulties in social skills and imagination were associated with failure of maternal–infant bonding. However, more attention to detail was associated with better maternal–infant bonding.

Conclusions

This study suggests that maternal autistic traits are related to anxiety and depression to a certain degree, but only slightly related to maternal–infant bonding at 1 month postpartum. To improve autistic women’s quality of life and that of their newborns, perinatal mental health issues such as anxiety, depression, and maternal–fetal bonding difficulties should be appropriately addressed.
Intronic position +9 and −9 are potentially splicing sites boundary from intronic variants analysis of whole exome sequencing data
Authors: Zhang Li , Shen Minna , Shu Xianhong , Zhou Jingmin , Ding Jing , Zhong Chunjiu , Pan Baishen , Wang Beili , Zhang Chunyan , Guo Wei
Published: June 2023

Whole exome sequencing (WES) can also detect some intronic variants, which may affect splicing and gene expression, but how to use these intronic variants, and the characteristics about them has not been reported. This study aims to reveal the characteristics of intronic variant in WES data, to further improve the clinical diagnostic value of WES. A total of 269 WES data was analyzed, 688,778 raw variants were called, among these 367,469 intronic variants were in intronic regions flanking exons which was upstream/downstream region of the exon (default is 200 bps). Contrary to expectation, the number of intronic variants with quality control (QC) passed was the lowest at the +2 and −2 positions but not at the +1 and −1 positions. The plausible explanation was that the former had the worst effect on trans-splicing, whereas the latter did not completely abolish splicing. And surprisingly, the number of intronic variants that passed QC was the highest at the +9 and −9 positions, indicating a potential splicing site boundary. The proportion of variants which could not pass QC filtering (false variants) in the intronic regions flanking exons generally accord with “S”-shaped curve. At +5 and −5 positions, the number of variants predicted damaging by software was most. This was also the position at which many pathogenic variants had been reported in recent years. Our study revealed the characteristics of intronic variant in WES data for the first time, we found the +9 and −9 positions might be a potentially splicing sites boundary and +5 and −5 positions were potentially important sites affecting splicing or gene expression, the +2 and −2 positions seem more important splicing site than +1 and −1 positions, and we found variants in intronic regions flanking exons over ± 50 bps may be unreliable. This result can help researchers find more useful variants and demonstrate that WES data is valuable for intronic variants analysis.
Evaluating a prototype digital mental health literacy intervention for children and young people aged 11–15 in Java, Indonesia: a mixed methods, multi-site case study evaluation
Authors: Brooks Helen , Irmansyah Irmansyah , Syarif Armaji Kamaludi , Pedley Rebecca , Renwick Laoise , Rahayu Atik Puji , Manik Christa , Prawira Benny , Hann Mark , Brierley Helen , Lovell Karina , Bee Penny
Published: June 2023

Background

The Improving Mental Health Literacy Among Children and Young People in Indonesia (IMPeTUs) intervention is a co-produced, evidence-based digital intervention designed to improve anxiety and depression focused mental health literacy and self-management among people aged 11–15 in Java, Indonesia. This study aimed to evaluate the usability, feasibility and preliminary impact of our intervention.

Methods

Mixed methods, multi-site case studies based on a theory of change. Pre-and post-assessments of a range of outcomes and qualitative interviews/focus groups with children and young people (CYP), parents and facilitators. The intervention was implemented in 8 health, school and community sites across Java, Indonesia (Megelang, Jakarta and Bogor).

Quantitative data designed to understand the impact of and feasibility of evaluating the intervention collected from 78 CYP who used the intervention were analysed descriptively. Qualitative data from interviews and focus groups collected from 56 CYP, 49 parents/caregivers and 18 facilitators were analysed using framework analysis.

Results

Qualitative data analysis indicated high levels of usability and acceptability for the interface aesthetic, personalisation, message presentation and navigation. Participants reported minimal burden and no negative outcomes associated with the intervention. CYP, parents and facilitators identified a range of direct and spill over effects of interventions engagement, some of which were not anticipated at study outset. Quantitative data highlighted the feasibility of intervention evaluation, with high levels of recruitment and retention across study time points. Minimal changes were identified in outcomes pre-to-post intervention, which may in part be due to a lack of scale relevance and/or sensitivity to the intervention mechanisms indicated in the qualitative data.

Conclusions

Digital mental health literacy applications are potentially an acceptable and feasible way to prevent burdens of common mental health problems amongst CYP in Indonesia. Our intervention and evaluative processes will be further refined prior to definitive evaluation.
Posttraumatic stress symptoms in adolescents and young adults with a chronic somatic disease: a mixed-methods study
Authors: Lunkenheimer Frederike , Mutter Agnes , Vogelmann Pauline , Baumeister Harald
Published: June 2023

Background

Adolescents and young adults (AYA) with a chronic somatic disease (CD) have a 3-fold higher risk of post-traumatic stress disorder (PTSD) than healthy controls. In addition, elevated post-traumatic stress symptoms (PTSS) have a negative impact on CD severity, treatment adherence, health problems and functional impairment. However, a more detailed understanding of this comorbidity is lacking.

Methods

AYA with type 1 diabetes mellitus, juvenile idiopathic arthritis or cystic fibrosis (12–21 years of age) and elevated anxiety and/or depression symptoms, as well as their reference persons (≥ 18 years of age), completed online questionnaires in self- or observer report. The most stressful event related to the CD was reported descriptively. Questionnaires were used to assess PTSS, anxious and depressive symptoms, actual overall health, coping, personal growth and social support. Qualitative content analysis, linear regression models and correlations were used for mixed methods analysis.

Results

According to the reports of n = 235 AYA (mean age 15.61; 73% girls) and n = 70 reference persons, four categories were identified as the most stressful events due to CD: (1) psychological burden (40% of AYA / 50% of reference persons); (2) CD self-management (32% / 43%); (3) social burden (30% / 27%); and (4) physical impairment (23% / 16%). 37% of AYA reported clinically relevant PTSS due to CD. The best predictors of PTSS severity were anxious-depressive symptoms, emotional coping, personal growth and current overall health (F(4, 224) = 59.404, R² = 0.515, p < .001). Of all categories, psychological (β = 0.216, p = .002) and social burden (β = 0.143, p = .031) showed significant association with the severity of PTSS (F(4, 230) = 4.489, R² = 0.072, p = .002). The more categories the most stressful event addressed, the higher was the PTSS symptom severity (r = .168, p = .010).

Conclusions

Many AYA showed clinically relevant PTSS and reported experiencing stressful events in several areas of life through their CD. The association between the stressful event categories and other variables could help identify AYA with CD who need psychological interventions the most.

Trial registration

: German Clinical Trials Register (DRKS): DRKS00016714, registered on 25/03/2019 and DRKS00017161, registered on 17/09/201.
Network intrusion detection based on multi-domain data and ensemble-bidirectional LSTM
Authors: Wang Xiaoning , Liu Jia , Zhang Chunjiong
Published: June 2023

Different types of network traffic can be treated as data originating from different domains with the same objectives of problem-solving. Previous work utilizing multi-domain machine learning has primarily assumed that data in different domains have the same distribution, which fails to effectively address the domain offset problem and may not achieve excellent performance in every domain. To address these limitations, this study proposes an attention-based bidirectional long short-term memory (Bi-LSTM) model for detecting coordinated network attacks, such as malware detection, VPN encapsulation recognition, and Trojan horse classification. To begin, HTTP traffic is modeled as a series of natural language sequences, where each request follows strict structural standards and language logic. The Bi-LSTM model is designed within the framework of multi-domain machine learning technologies to recognize anomalies of network attacks from different domains. Experiments on real HTTP traffic data sets demonstrate that the proposed model has good performance in detecting abnormal network traffic and exhibits strong generalization ability, enabling it to effectively detect different network attacks simultaneously.
SipNose-topiramate: a potential novel approach to binge eating management
Authors: Kobo-Greenhut Ayala , Zohar-Beja Adit , Hadar Liron , Itzhaki Lior , Karasik Avraham , Caraco Yoseph , Frankenthal Hilel , Shahaf Daniel , Ekstein Dana , Shichor Iris , Gur Eitan
Published: June 2023

Background

Binge-eating disorder) BED) is the most common eating disorder in the United-States. Daily, orally administered topiramate has shown BED treatment efficacy, with two major limitations: frequent and severe side effects and slow time-to-effect. SipNose is a novel non-invasive intranasal direct nose-to-brain drug delivery platform that delivers drugs to the central nervous system consistently and rapidly. Herein, we study a SipNose-topiramate combination product, as an acute “as needed” (PRN) solution for BED management.

Methods

First, SipNose-topiramate’s pharmacokinetics (PK) and safety was evaluated. The second part aimed to demonstrate its PRN-treatment feasibility in terms of usability and potential efficacy in reducing the number of binge-eating events. Twelve BED patients were studied over three time periods; 2-weeks of baseline monitoring [BL], 8-weeks of treatment [TX], and 2-weeks of follow up [FU].

Results

The PK profile showed peak plasma levels at 90 min post-administration, a t1/2 > 24 h and consistent topiramate delivery with no adverse events. In the second part, 251 treatments were self-administered by the patient participants. There was a significant reduction from baseline to treatment periods in mean weekly binge-eating events and binge-eating event days per week. This was maintained during the follow up period. Efficacy was corroborated by improved patient illness severity scales. There were no adverse events associated with any administered treatments. Patients were exposed to less drug when compared with accepted oral dosing.

Conclusions

This study introduces a SipNose-topiramate drug-device combination as a potentially safe, effective, and controlled method for BED management. Its findings introduce a potential approach to BED management both as an intranasal and as a PRN therapy for reducing binge-eating events, with a large-scale reduction in patient drug exposure and side effects and with improved patient quality of life. Further studies are needed with larger patient populations to establish SipNose-topiramate as a mainstream treatment for BED.

Trial registration: Registration number and date of registration of the clinical studies reported in this article are as follows: 0157-18-HMO, August 15th 2018 and 6814-20-SMC, December 2nd 2020.
Ultrafine and crosstalk-free 2D tactile sensor by using active-matrix thin-film transistor array
Authors: Kinjo Hiroumi , Tanaka Hitoshi , Haga Yuta , Tamaru Takaya , Kobashi Junji , Sako Kazuhiko , Yamaguchi Kazunori , Oka Shinichiro
Published: June 2023

Passive matrix (PM) technologies are widely used in various fields (e.g., manufacturing, human sensing, and robotics) to visualize the tactile pressure distribution. These technologies are powerful addressing methods with simple structures, low cost, and easy fabrication steps. However, crosstalk problems have been pointed out, especially in high-resolution fields. To prevent a crosstalk occurrence, we adapt active-matrix (AM) technologies for ultrafine tactile imaging. In this work, two-dimensional (2D) tactile sensors are prepared using AM arrays fabricated through standard display processes. Pressure-sensitive resistor sheets are then attached. The sensors have 6720 px in a 90 × 90 mm sensing area with a 1.1 mm pixel pitch. The crosstalk is evaluated by pressurizing the control area of the sensor and measuring the output in the non-pressurized area. No pixel is affected by the pressure outside the pixel itself, or no crosstalk occurs. For a demonstration, static pressure from soft toy balls and dynamic foot pressure during walking are loaded to the 2D tactile sensors. The differences in the contact mode by the ball type and the pressure of each finger are observed, thanks to the 1.1 mm-pitch without crosstalk. The 2D tactile sensors presented herein will contribute to the fundamental understanding of the contact interface and will have practical usage in sport sciences, biometric identifications, and tactile sensation of robots.
Outcome of extradural devascularization in resection of giant olfactory groove meningioma in bilateral subfrontal approach
Authors: Elsisi Yasser Bahgat , Hossen Mohamed Adel , Al Emam Saeed Esmaeel
Published: June 2023

Background

Olfactory groove meningioma (OGM) is characterized by slow-growing tumors that are frequently bilateral as opposed to unilateral & asymmetrical and may cause progressive frontal lobe compression. We aimed to evaluate the value of extradural devascularization as a golden step in bilateral subfrontal approach in management of OGM.

Results

The mean operative time was 158.32 ± 24.88. Blood loss ranged from 500 to 1000 cc with a mean value of 763.64 ± 155.98. The number of patients requiring blood transfusion was 5 (22.7%). Based on Simpson classification, 19 (86.4%) patients had whole tumor excision (grade I, II) & 3 (13.6%) patients had grade III and IV. The incidence of complications among the studied patients is: CSF leak did not occur to any case, pneumocephalus occurred in 1 (4.5%) patient, anosmia occurred in 1 (4.5%) patient, focal CNS deficit occurred in 1 (4.5%) patient, wound infection occurred in 1 (4.5%) patient and hematoma occurred in 1 (4.5%) patient. Only 1 (4.5%) case died due to pulmonary embolism, whereas behavioral manifestations occurred in 9.09% of patients.

Conclusions

The extradural devascularization is a golden step in this approach in management of OGM associated with lower incidence of blood loss intraoperatively (total blood loss was 500–1000 mL, recurrence rate, mortality and additional neurological deficits postoperatively.
A tergo
Authors: Rambuss Richard
Published: June 2023

This essay reflects on Bersani’s sexually explicit, homosexually specific writings about sex from the vantage of sexual positioning, which can itself be thought of as complexly gendered, corporeally and psychically. Whereas gay male sex in the missionary position is the centerpiece of Bersani’s famous essay “Is the Rectum a Grave?,” Homos, the no less polemical book that follows it, also theorizes another position: coitus a tergo, the approach to what is behind from behind. Through a reading of Genet’s wartime erotic novel Funeral Rites, which is replete with a tergo couplings, Bersani makes his case for the transportive value of nonrelational sex, while retaining an indicatively male-male erotic specificity. These theorizations also open onto a noncastrative rereading of the Wolf Man’s story, which likewise turns on coitus a tergo, offering a gay rereading that, this essay suggests, points to a possibility of relationality.
Coercion
Authors: Khalip Jacques
Published: June 2023

This essay treats the concept of coercion in Leo Bersani’s writings as a matter connected to questions of aesthetic form, mobility, and immobility. It reads passages from his work on Derek Jarman’s film Caravaggio, among others, to argue for noncoercive modes of attention and relationality.
Fascination
Authors: Roach Tom
Published: June 2023

Bersanian fascination is not merely a fleeting affective state. It is, rather, a mode of inquiry and a form of being. If Bersani is initially fascinated with the antisocial nature of sexual desire, he later becomes enthralled with a notion of fascinated witnessing that reveals an ontological enmeshment. This essay homes in on a passage in Homos that presages an important pivot in Bersani’s intellectual trajectory: a pivot from a dialectical conception of a subjectivity forever alienated and at odds with external reality to an immanentist understanding of a subject always already connected to the world. Through an act of betrayal, Bersani leaves behind a Freudo-Proustian conception of desire as lack and embraces a concept of desire so radically exclusionary that it lacks nothing. Betrayal affords Bersani the opportunity to conceive of an ethical response to an inherently exclusionary sexual desire: an implicated, indiscriminate fascination with the world’s appearances, indifferent to the psychology of desire.
Im/mobility
Authors: Downing Lisa
Published: June 2023

In Baudelaire and Freud (1977), Leo Bersani posits that psychoanalysis offers a way of understanding sexuality as characterized by the mobility of fantasy, rather than by the content of fetishes or sexual identities, and that this mobility offers the “potential for explosive displacements.” This short meditation explores how mobility as a concept, understood in Bersani’s sense, helps us think beyond some of the paradoxes, redundancies, and aporias in both psy science and queer theoretical models of sexuality. The essay closes by showing how Bersani returned to “mobility” in Homos (1995) and argues that, via this concept, he suggests ways that queer theory itself can avoid becoming a “new normativity.”
Less
Authors: Clark David L.
Published: June 2023

Leo Bersani is well known for making a case for the pleasures of sameness. But “to circulate within sameness,” he notes, “we must first of all welcome [ . . . ] lessness.” This essay explores that hospitable gesture in Bersani’s work, focusing on the self-abnegating practice of willing ourselves “to be less than who we are.” What does it mean to be “uncontaminated by a psychology of desire” and “unaccompanied by an essentially doomed and generally anguished interrogation of the other’s desire”? There can be no single answer to that ethically consequential question, which explains the jubilant restlessness of Bersani’s oeuvre. The author concludes with a reading of Freud’s infamous fort/da game, arguing that the child lessens his stake in a magisterial and anxious identity so as to extend himself, or parts of himself, joyfully and impersonally, into the world.
Sentences
Authors: Edelman Lee
Published: June 2023

Focusing on a passage where Leo Bersani addresses the intensity of his attachment to many of his first sentences—sentences that seemed to come all at once and to betray his own understanding of the topics they introduced—this essay considers that betrayal in relation to his view of homosexuality as betraying the seriousness of statements. By examining how the latter betrayal gets enacted in the betrayal his sentences perform, it identifies the tension in Bersani’s work between an explicit resistance to the “de-gaying” he associates with queer theory and the “de-gaying” impulse of his own work, which made it central to queer theory itself.
Sociological
Authors: Lucey Michael
Published: June 2023

In Thoughts and Things, Bersani juxtaposes Jean Genet’s novel, Our Lady of the Flowers with some of Pierre Bourdieu’s thinking about how naming works. Bersani finds in Genet’s novel a moment of unnamability that is, for him, a challenge to the legitimating naming power of the state and that justifies favoring a psychoanalytic framework over Bourdieu’s, whatever the power of Bourdieu’s thinking about naming and about structures of domination. This article challenges Bersani’s reading of Genet’s novel, which is more sociological that Bersani allows for. It also challenges Bersani’s understanding of Bourdieu’s thinking about naming and the state.
Soku
Authors: Haver William
Published: June 2023

This essay explores Leo Bersani’s concept of the “continuity of being,” a concept that attempts to overcome the epistemophiliac Cartesian dissociation of res cogitans from res extensa by means of phenomenological considerations of the proximate milieu, as well as a metaphysical intuition of the virtual One-All. The conception of the co-immanence of the One-All and the multiplicity of beings is pertinent to considerations of contemporary pandemics as well as to the climate crisis insofar as it offers neither hermeneutic resolution, policy diktats, or moral judgment, but simply one among many possible points of departure for whatever will count as thinking in whatever future there may be.
A retrospective study comparing open and percutaneous trigger finger release in the Thai population
Authors: Malisorn Saran
Published: June 2023

Background: Over the years, open surgery has been the primary treatment for trigger finger, a prevalent issue among hand illnesses. There has been some resistance to the technique's routine use, despite the fact that the percutaneous release of triggers provides a quicker recovery than surgery. As a result, the study proposed that the percutaneous release technique outperforms open surgery. The objective of this study was to compares the trigger finger surgery's open and percutaneous releases in terms of short-term results.

Methods: From 2014 to 2020, 166 patients who underwent open or percutaneous release surgery for the trigger finger at Naresuan University Hospital were the subjects of this retrospective analysis. For one, three, and six weeks, the initial characteristics and post-operative hemorrhage, digital nerve and artery injury, surgical site pain, inability to flex the finger, and other outcomes were compared. The visual analog scale (VAS) score and the impairments of the arm, shoulder, and hand (DASH) score were also compared between the two groups.

Results: The age, sex, and number of patients in both groups were statistically comparable. Before the procedure, there was no difference between the groups in terms of DASH and VAS scores for pain; however, at six weeks, the percutaneous release group showed a substantial difference and low VAS scores. There were no differences between the groups in terms of consequences, including wound pain, damage to digital nerves and arteries, and others.

Conclusion: Based on the patients' short-term outcomes, the study found that percutaneous release of the trigger finger is just as successful as traditional open surgery.
Synchronous borderline ovarian tumor with endometrioid endometrial carcinoma - from diagnosis to treatment. A Case study
Authors: Kolasa Eliza , Paluch Alicja , Satora Małgorzata , Kułak Krzysztof
Published: June 2023

Introduction

The occurrence of two primary tumors at an interval of no more than two months is called a synchronous tumor. This also applies to female reproductive organs among which synchronous occurrence of ovarian and endometrial cancers is most frequently observed. This phenomenon is observed mainly in young women before menopause. A rare and problematic diagnostic situation is the synchronous co-occurrence of borderline ovarian carcinoma with endometrioid carcinoma of the endometrium. The diagnostic problem and treatment of this combination of cancers are presented in the following case.

Case description:

A 30-year-old female patient presented to the Gynecologic Oncology Department with a suspected malignant lesions of both ovaries. She underwent fertility-sparing surgery with preservation of the left ovary and uterus. Examination of the resected tissues revealed an endometrioid borderline tumor. During the next hospitalization, an excision of uterine polyps was performed, during which no neoplastic lesion of the endometrium was observed. Ultrasound examination, in which the endometrial lesion was also invisible, raised suspicion of cancer recurrence on the left ovary. The patient was scheduled for resection of the left ovary with the recurrence and hysterectomy. The histopathological examination performed confirmed the recurrence on the ovary and showed foci of G1 endometrioid carcinoma of the uterus.

Conclusions

Cases that meet the criteria for synchronous tumor occurrence should be considered. Appropriate diagnosis and selection of radical treatment could affect the curability of patients. Further research on rare combinations of synchronous neoplasms could be helpful in clinical practice.
Los animales como sujetos de derechos: una categoría jurídica en disputa
Authors: Sánchez Jaramillo Johana Fernanda
Published: June 2023

Esta obra analiza y cuestiona, desde una mirada abolicionista, el estatus jurídico de los demás animales en varias ramas del derecho en Colombia, América Latina y otros países, como Estados Unidos, Francia, España y Reino Unido. El tema central es la necesidad de descosificarlos, para que adquieran el estatus de sujetos de derechos. El objetivo del libro es determinar las razones por las cuales los animales son vistos como cosas, propone alternativas para una nueva categorización e identifica los avances nacionales e internacionales en esta materia. Lo anterior se desarrolla a través de la metodología cualitativa ,usando como fuentes la doctrina, la normatividad, la jurisprudencia y nueve entrevistas a expertos, quienes exponen el estado de la cuestión en sus países. En este libro, el lector encontrará el trato que el derecho colombiano le da a los animales y algunas recomendaciones para cambiar y mejorar esta situación.
SpeckleCam: High-resolution Computational Speckle Contrast Tomography for Deep Blood Flow Imaging
Authors: Maity Akash , Veeraraghavan Ashok , Sabharwal Ashutosh , Sharma Manoj
Published: June 2023

Laser speckle contrast imaging is widely used in clinical studies to monitor blood flow distribution. Speckle contrast tomography, similar to diffuse optical tomography, extends speckle contrast imaging to provide deep tissue blood flow information. However, the current speckle contrast tomography techniques suffer from poor spatial resolution and involve both computation and memory intensive reconstruction algorithms. In this work, we present SpeckleCam, a camera-based system to reconstruct high resolution 3D blood flow distribution deep inside the skin. Our approach replaces the traditional forward model using diffuse approximations with Monte-Carlo simulations-based convolutional forward model, which enables us to develop an improved deep tissue blood flow reconstruction algorithm. We show that our proposed approach can recover complex structures up to 6 mm deep inside a tissue-like scattering medium in the reflection geometry. We also conduct human experiments to demonstrate that our approach can detect reduced flow in major blood vessels during vascular occlusion.
Seroprevalence of SARS-CoV-2 and risk factors in Bantul Regency in March-April 2021, Yogyakarta, Indonesia
Authors: Ahmad Riris Andono , Indriani Citra , Arisanti Risalia Reni , Nanda Ratih Oktri , Mahendradhata Yodi , Wibawa Tri
Published: June 2023

COVID-19 case counts in Indonesia inevitably underestimate the true cumulative incidence of infection due to limited diagnostic test availability, barriers to testing accessibility and asymptomatic infections. Therefore, community-based serological data is essential for understanding the true prevalence of infections. This study aims to estimate the seroprevalence of SARS-CoV-2 infection and factors related to the seropositivity in Bantul Regency, Yogyakarta, Indonesia. A cross-sectional study involving 425 individuals in 40 clusters was conducted between March and April 2021. Participants were interviewed using an e-questionnaire developed in the Kobo toolbox to collect information on socio-demographic, COVID-19 suggestive symptoms, history of COVID-19 diagnosis and COVID-19 vaccination status. A venous blood sample was collected from each participant and tested for immunoglobulin G (Ig-G) SARS-CoV-2 antibody titers using the enzyme-linked immunosorbent assay (ELISA). Seroprevalence was 31.1% in the Bantul Regency: 34.2% in semi-urban and 29.9% in urban villages. Participants in the 55–64 age group demonstrated the highest seroprevalence (43.7%; p = 0.00), with a higher risk compared to the other age group (aOR = 3.79; 95% CI, 1.46–9.85, p<0.05). Seroprevalence in the unvaccinated participants was 29.9%. Family clusters accounted for 10.6% of the total seropositive cases. No significant difference was observed between seropositivity status, preventive actions, and mobility. Higher seroprevalence in semi-urban rather than urban areas indicates a gap in health services access. Surveillance improvement through testing, tracing, and treatment, particularly in areas with lower access to health services, and more robust implementation of health protocols are necessary.
Evaluation of tarsal injuries in C57BL/6J male mice
Authors: Kick Brenda L. , Anderson Laura , Doty Rosalinda , Wooley Christine , Dyer Meaghan , Green Torrian , Knickerbocker Veronica , Brown Zoe , Loeber Samantha , Wotton Janine , Lyons Bonnie , Waterman Linda , Bichler Zoë
Published: June 2023

Tarsal joint abnormalities have been observed in aged male mice on a C57BL background. This joint disease consists of calcaneal displacement, inflammation, and proliferation of cartilage and connective tissue, that can progress to ankylosis of the joint. While tarsal pathology has been described previously in C57BL/6N substrains, as well as in STR/ort and B10.BR strain, no current literature describes this disease occurring in C57BL/6J mice. More importantly the behavioral features that may result from such a change to the joint have yet to be evaluated. This condition was observed in older male mice of the C57BL/6J lineage, around the age of 20 weeks or older, at a frequency of 1% of the population. To assess potential phenotypic sequela, this study sought to evaluate body weight, frailty assessment, home cage wheel running, dynamic weight bearing, and mechanical allodynia with and without the presence of pain relief with morphine. Overall mice with tarsal injuries had significantly higher frailty scores (p< 0.05) and weighed less (p<0.01) compared to unaffected mice. Affected mice had greater overall touch sensitivity (p<0.05) and they placed more weight on their forelimbs (p<0.01) compared to their hind limbs. Lastly, when housed with a running wheel, affected mice ran for a shorter length of time (p<0.01) but tended to run a greater distance within the time they did run (p<0.01) compared to unaffected mice. When tested just after being given morphine, the affected mice performed more similarly to unaffected mice, suggesting there is a pain sensation to this disease process. This highlights the importance of further characterizing inbred mouse mutations, as they may impact research programs or specific study goals.
The enabling environment for citywide water service provision: Insights from six successful cities
Authors: Trimmer John T. , Qureshi Haleemah , Otoo Miriam , Delaire Caroline
Published: June 2023

Equitable access to safe drinking water remains a key challenge in many urban areas of low- and middle-income countries. This study aimed to characterize the enabling environment for inclusive urban water service delivery, and specifically to elucidate the institutional arrangements, policies, regulations, service delivery approaches, financing models, and surrounding contextual factors that influence progress. We identified six cities across Africa, Asia, and South America that offered historical examples of success in inclusive piped water provision, resulting in high levels of access and service quality, including within low-income areas. Using a modified form of the social-ecological systems framework to structure our investigation, we conducted a comparative case study analysis to learn from these cities. Our analysis focused on a review of existing case-specific literature, supplemented by interviews with 1–3 key informants per case to update or fill gaps in the literature. A variety of characteristics supported safe and inclusive services, with contextually appropriate strategies depending on existing institutional arrangements, infrastructure, and the surrounding social, economic, political, and environmental context. Our study cities illustrated three types of progress–utility-driven, regulator-supported, and municipality-driven–each characterized by specific features and drivers of success. We also identified 12 characteristics making up the enabling environment across all three types. These characteristics highlighted two broad themes. First, a well-functioning water service provider was often a prerequisite for inclusive, pro-poor service provision. Elements such as clear performance indicators, customer feedback mechanisms, and strategies to sustainably finance operating costs contributed to cities’ success. Second, inclusive water services often required explicit pro-poor policies and strategies, such as the removal of land tenure requirements for piped connections and community mobilization for participatory decision-making. Although the importance of specific characteristics will vary depending on context, our analysis offers a common foundation to guide progress toward universal access to safe water.
Romanticismo de acero
Authors: Polo Blanco Jorge
Published: June 2023

Múltiples e intrincadas fueron las causas que produjeron algo tan aberrante como el nacionalsocialismo. En el presente trabajo solo abordaremos ciertas cuestiones que tienen que ver con las raíces filosóficas y culturales del nazismo. Observaremos que, si bien es cierto que también surgieron filosofías irracionalistas en otras naciones de Europa, fue en Alemania donde se desarrollaron con mayor fuerza e intensidad. Consideraremos, como hipótesis principal, que la comprensión cabal de ciertos acontecimientos históricos –máxime si son tan disruptivos como el nazismo– requiere de una exploración de sus genealogías intelectuales inmediatas y remotas.
A Vergonha na Narrativa do Pour-Soi. Sobre L’Être et le Néant
Authors: Falcato Ana
Published: June 2023

Expõe-se neste ensaio o sentido da inclusão de uma impressão de vergonha como pedra de toque afetiva que reverte a tentação solipsista que ameaça qualquer projeto de uma filosofia transcendental, ao mesmo tempo que se enquadra a respetiva relevância na narrativa conceptual do «cogito», traçada por Sartre em O Ser e o Nada. São preservadas duas notas metodológicas sobre a interpretação da obra, que poucas vezes sobrevivem em reconstruções parciais de alguns dos seus temas mais relevantes. Por um lado, preserva-se o aspeto estritamente descritivo da afeção de vergonha e o que esta revela sobre a subjetividade como formalmente entendida por Sartre; por outro, mantém-se aqui uma fidelidade teórica às diferentes etapas da narrativa conceptual do Pour-Soi, que Sartre herda da tradição idealista e adapta às principais necessidades de uma descrição fenomenológica das diferentes fases da nossa experiência do mundo exterior à consciência. O ensaio pretende manter a fidelidade ao papel descritivo atribuído por Sartre à impressão de vergonha no interior da complexa narrativa conceptual do Pour-Soi e respetivos estágios evolutivos e aos detalhes do momento de vergonha isolado para análise e a como se coadunam ou não com a dimensão intuitiva e abordagens teóricas contemporâneas desta tão peculiar emoção moral.
Misticismo, sexualidade e relações de gênero no quietismo radical de Miguel de Molinos
Authors: Vainfas Ronaldo
Published: June 2023

O artigo examina a doutrina de Miguel de Molinos, exposta no Guia espiritual (1675), sua difusão em Roma e condenação pela Igreja (1687), bem como a do próprio teólogo pela Inquisição romana. Insere a citada doutrina no pensamento místico do século XVII, em particular no quietismo. Discute o caráter herético desta doutrina, relacionando-a à busca da santidade e da contemplação como meios de salvação espiritual. Avalia se a liberação dos desejos sexuais por esta doutrina é o ponto central de sua condenação como heresia. Expõe o caso do «grupo de Viseu», em particular o de Joana Maria de Jesus, baseado no processo do Santo Ofício de Lisboa. Relaciona a doutrina e a prática do chamado Molinosismo, uma espécie de Quietismo radical, com o modelo católico das relações de gênero e o combate à pastoral do medo em favor da desculpabilização dos pecados, ideal que muito favorecia as mulheres.
Mãe e esposas
Authors: Lôpo de Araújo Erica , Souza Alexandre
Published: June 2023

A despeito dos estudos sobre relações de gênero e das inúmeras revisões e verdadeiras revoluções epistemológicas ocorridas nos últimos anos, a pesquisa histórica, nas suas mais diversas abordagens metodológicas, é, tradicionalmente, centrada em figuras masculinas. Buscando refletir acerca dessa constatação e em consonância com o uso da categoria de gênero e conceito de «lugar de nascimento», este artigo pretende mostrar, a partir de um estudo de caso, como as trajetórias de serviço e experiências de governação portuguesa foram atravessadas por relações familiares e de gênero. Argumenta-se o papel fundamental desempenhado pelas mulheres que cercavam D. Vasco de Mascarenhas – Conde de Óbidos –, e que contribuíram para sua ascensão, viabilizando ações e inserção social e política em meados do século XVII.
Black pearls in Little Africa
Authors: Furtado Junia
Published: June 2023

The village of Tejuco, now the town of Diamantina, was the center of the Diamond District in the Northeast of the captaincy of Minas Gerais. The aim of this article is to unveil, using a census and a map from around 1774, some of the layers of the feminine geography of the social life of the village. This reveals a more dynamic and plural configuration of Tejuco, where a significant number of people of color, mostly black African women, were heads of household. Their presence transformed Tejuco into a Little Africa.
A Gazeta das Damas (1822) e o estatuto ambíguo da cidadania feminina na 1ª metade do século XIX
Authors: Tavares da Silva Diana
Published: June 2023

O presente artigo propõe-se refletir, a partir de um estudo de caso, um periódico de 1822 dirigido ao público feminino – a Gazeta das Damas de Caetano António de Lemos – sobre um tema que só muito superficialmente tem interessado à historiografia das fases iniciais do Liberalismo português, isto é, em que medida a rutura que se operou no triénio vintista (1820-1823) deu às mulheres uma maior visibilidade pública, trazendo-as, ainda que de forma discreta, para a vida cívica e levando a sociedade a questionar o seu lugar nela.
HOW INTERNATIONAL STANDARDS OF WOMEN'S RIGHTS WERE BORN: THE EXPERIENCE OF ANALYZING THE LEGAL POLICY OF THE UNITED NATIONS IN THE 1950–1970S.
Authors: Головинов А.В. , Golovinov Yu.V.
Published: June 2023

The purpose of the article is to show the history of the formation of the legal foundations of genderequality in the rule-making activities of the United Nations in the period of 1950–1970s. The chronologicalframework was not chosen by chance, it was for the 50–70s. 20th century there was an active phase of the  adoption of legal contractual documents in the field of the institution of the rights of women and men. Theauthors analyze the consistent history of the UN legal policy in this area.The article establishes that a decisive struggle against gender asymmetry fell on the initial stage of theformation of an organization that aims at world peace. In general, the authors come to the conclusion thatfrom the second half of the XX century. in the world community, the process of developing internationallegal acts in the field of protecting women's rights has been developed. Progress in defining the essence andcontent of women's rights proceeded naturally and evolutionarily. International conventions and pacts inthis area were progressively adopted. Ultimately, women were equalized with men. Anti-discriminationinternational legislation was actively developed.
Metaverse is emerging!
Authors: Mehta Niket , Joshi Naval
Published: June 2023

Human beings being curious and experimental in nature always look forward to making good use of any technology and latest is Metaverse which is a combination of Interactive tools and Technologies like Digital Games, Augmented and Virtual Reality, social media, and Internet. This paper, which is based on literature review explains the Metaverse, its uses and challenges, discusses an example – PartyNite, and future scope of Metaverse.
Dinâmica hidrogeológica dos aquíferos costeiros da Cidade de Quelimane, Moçambique
Authors: Palé Suaraia Abdul , Simbe Manuel Pedro Tomo , Miguel Lucas Lavo Antonio Jimo
Published: June 2023

A dinâmica hidrogeológica dos aquíferos costeiros da Cidade de Quelimane é estudada através de dados históricos provenientes de furos fornecidos pela Direcção Nacional de Águas (DNA). As variáveis hidrogeológicas dos furos foram analisadas e processadas no programa Surf-11, planilha de Excel, e auxiliadas com as técnicas de geoprocessamento em ArcGIS na representação de mapas cartográficos adaptados das cartas explicativas da Direção Nacional de Geologia de Moçambique. A profundidade média de furos de ~12,27m mostrou uma variação do nível estático entre 1.8m.-sup e 4.0 m.-sup, com vazões de bombeamento variando de 0 a 2.36 m3/h, e o nível dinâmico varia de 0 a 9.0m.-sup. O nível estático mostrou-se menos profundo, inferindo-se mais susceptíveis à contaminação hídrica. A superfície potenciométrica sugeriu uma dinâmica do fluxo subterrâneo, cujo escoamento é predominantemente da direção Noroeste e também para o Sudeste. Estas informações hidrogeológicas auxiliarão na análise pioneira dos aquíferos localizados nas zonas costeiras susceptíveis efeitos cíclicos das marés, inundações urbanas e ciclones tropicais.
The European Parliament’s AI Regulation
Authors: Haataja Meeri , Bryson Joanna J.
Published: June 2023

The European Union (EU) has been leading the world with its influential digital regulation. However, the EU’s legislative process is sufficiently complex and careful that some national legislation clearly influenced by the EU’s AI Regulation is already in place in other countries, before the law has even been finalized in the EU. Meanwhile, other states and regions are just beginning to develop AI policy. For both the EU and such others, we here describe the outcomes of the first round of legislative action by one of the EU’s two legislative bodies, the European Parliament, in terms of modifying the Artificial Intelligence Act. The Parliament has introduced a number of changes we consider to be enormously important, some in a very good way, and some in a very bad way. At stake is whether the AI Act really brings the power and strength of product law to continuously scale improved practice on products in the EU with intelligent components, or whether the law becomes window-dressing aimed only at attacking a few elite actors post hoc. We describe here the EU process, the changes and our recommendations.

Keywords: AI Act; digital governance; AI regulation; parliamentary processes; European Union; transnational regulation.
A British Bundesrat? The Brown Commission and the Future of the House of Lords
Authors: Meggitt Gary
Published: June 2023

Reform of the House of Lords has occupied the minds of politicians, civil servants and academics for over a century. In late 2022, the Labour Party published a proposal for the replacement of the Lords with a new, democratically elected, Assembly of the Nations and Regions. This proposed Assembly resembles, at least superficially, the German Bundesrat. The author reviews the history of Lords reform, examines Labour’s proposals, compares the envisioned Assembly with the Bundesrat and concludes that the former will be found wanting.

Keywords: United Kingdom; Germany; constitutional law; Parliament; House of Lords; Bundesrat; constitutional reform.