bluuebunny/crossref_metadata_2025 huggingface dataset:
O que é isto: a sociedade sem o homem?
Authors: Galvão Vasconcelos de Almeida André
Published: November 2022

A teoria dos sistemas sociais de Niklas Luhmann, não raramente, recebe a crítica de promover uma espécie de “anti-humanismo ético”, no sentido de desconsiderar a importância do sujeito na sociedade, assim como um conservadorismo demasiado, sobretudo em relação ao sistema jurídico, no sentido de desconsiderar a dinâmica das mudanças sociais. A partir desse contexto, o presente trabalho pretende contribuir para desmitificar tais ideias e evitar certos “preconceitos” teóricos, de modo a oferecer ferramentas para os que desejam ingressar no estudo sobre o pensamento luhmanniano. Busca-se, portanto, fazer observações capazes de descrever os principais aspectos que norteiam o conceito de sociedade de comunicação e, posteriormente, identificar o papel exercido pelo direito dentro do contexto social altamente complexo e dinâmico. Para tanto, a metodologia da pesquisa se fundamenta em uma exploração bibliográfica, com revisão de literatura específica, fazendo-se imprescindível a abordagem de temas caros à referida teoria, tais como: o “deslocamento” o homem para o ambiente/entorno do sistema social, a posição da comunicação como elemento constitutivo da sociedade, o próprio conceito de comunicação e sua improbabilidade, face aos desafios da sociedade contemporânea, assim como o papel dos meios de comunicação simbolicamente generalizados.
Experimental Study on Concrete Using Alccofine
Authors: Mishra Pankaj , Rangnekar Prof. Vivek
Published: November 2022

Abstract: This paper deals with experimental investigation on mechanical properties of M20 grade concrete with the aid of using alccofine in the mix. Alccofine of 0%. 5%, 10%, 15%, 20%, 25% and 30% by weight of cement are replaced with cement in the concrete mix. A comparative analysis has been completed for conventional concrete to that of the alccofine used concrete on the subject of compressive and split tensile strength. As in previous studies alccofine content material will increase compressive and split tensile strengths are proportionally increasing. It is found that as much as 25% of alccofine replaced with cement by weight of cement will increase the strength of concrete and later starts reducing the strength.
TRANSPARENCIA EN MATERIA DE CORRUPCIÓN Y SOBORNO
Authors: Orias Paredes Andrea , Morales Parada Fernando
Published: November 2022

La transparencia empresarial se ha convertido en una práctica esencial para generar valor en las compañías. Por ello, es que el objetivo de esta investigación es determinar el nivel de transparencia de una muestra empresas cotizadas chilenas, pertenecientes al IPSA-30. Se examinará la información que divulgan las empresas en la memoria anual, memoria integrada o en su defecto en el reporte de sostenibilidad presente en los sitios web de cada compañía con el fin de analizar el comportamiento de la reportabilidad de la información de acuerdo al marco normativo vigente en Chile a partir de una lista de chequeo. De los resultados, del análisis por dimensión se obtuvieron buenos resultados, se presenta un énfasis en relación a las Políticas anticorrupción. El ranking evidenció que solo 2 empresas cumplieron con la totalidad de lo evaluado que son Viña concha y toro y Colbun. Mientras que de acuerdo al análisis por sector empresarial se logra evidenciar que los sectores como el consumo, industrial y el comercio presentan un destacado nivel de cumplimiento y preocupación por combatir la corrupción en sus diversas formas. Se concluye que, a pesar de sus avances, aún hay un gran margen de mejora en los niveles de divulgación.
Analyzing organizational factors in Greek tourism services
Authors: Belias Dimitrios , Rossidis Ioannis , Lazarakis Panagiotis , Mantas Christos , Ntalakos Angelos
Published: November 2022

The purpose of the paper is to investigate the interaction of human resource management, strategic leadership, role conflict, job commitment, and job stress of employees in a public tourism organization. The value of this paper lies in the fact that human resources are undoubtedly the most important asset for both private tourism businesses and public tourist organizations (Ntalakos, Belias, & Koustelios, 2022a; Ntalakos, Belias, & Tsigilis, 2022b; Belias & Trihas, 2022a). The success or failure of the goals set by the respective administration depends on this. The above variables interact with each other and affect employee performance, as strategic leadership decisions will affect job stress and job commitment (Belias, Rossidis, Sotiriou, & Malik, 2022). The empirical data used in this paper has been derived from quantitative research which occurred in a sample of 190 persons working in hotels. The outcome of the research is that strategic leadership has an effect on work stress, while it also affects job commitment and the lack of a sense of belonging to the organization. Furthermore, role conflicts affect both job commitment with work stress, while work stress has also an effect on job commitment. An important conclusion is that work stress is not a moderator variable for the examined relationships. Based on the outcome of the research, the recommendation is that public Greek organizations need to empower their human resource management so to increase the job commitment and the leadership capacity of their employees but also to make sure that the work environment is able to reduce stress.
Vaginoplasty for Gender Dysphoria and Mayer-Rokitansky-Küster-Hauser Syndrome: A Systematic Review and Meta-analysis
Authors: Sueters Jayson , Groenman Freek , Bouman Mark-Bram , Roovers Jan-Paul , Vries Ralph de , Smit Theo , Huirne Judith
Published: November 2022

BACKGROUND: About 8,800-34,200 Gender Dysphoria (GD)- and 39,000-650,800
Mayer-Rokitansky-Küster-Hauser (MRKH)-patients undergo vaginoplasty
annually. Various procedures are available, but comparisons are lacking.
OBJECTIVES: To highlight information gaps, weaknesses and strengths of
vaginoplasty techniques, to aid well-informed decision making by
patients and healthcare professionals. SEARCH STRATEGY: A systematic
search in Medline, EMBASE, Web of Science and Scopus until October 6,
2022, by PICO method and PROSPERO registration. SELECTION CRITERIA:
Original retrospective studies on complete neovaginal creation in adult
GD- and MRKH-patients and discussing anatomy, Quality of Life (QoL),
satisfaction, sexual function, complications or complaints. DATA
COLLECTION AND ANALYSIS: The 95% confidence intervals were calculated
with DerSimonian and Laird random-effects. Methodological quality and
potential bias were assessed. MAIN RESULTS: In total, 35 GD- and 16
MRKH-studies were eligible. Vagina length was 11.6 and 9.5 cm,
respectively. In GD-patients, Hemorrhage (6%), prolapse (1%),
gastrointestinal complications (1%), revisions (26%), pain (6%),
regret (1%), fecal- (11%) and urinary issues (17%) were reported.
Necrosis, stenosis, dyspareunia and revisions decreased, while duration
increased with higher graft quantity. Intestinal-vaginoplasty reported
100% sensation. MRKH-patients reported more necrosis (17%)
[McIndoe] and average satisfaction with sexual function (91%) and
vaginal discharge (32%). They were more sexually active (86%) and had
100% anatomical satisfaction. Only Intestinal-vaginoplasty reported
overall dissatisfaction. CONCLUSIONS: For GD- and MRKH-patients,
multiple safe vaginoplasty techniques demonstrated acceptable outcomes,
with significantly improved QoL and self-image. However, standardized
validation tools are needed for well-informed decision-making. Direct
technique comparisons per patient-cohort and exploration of
tissue-engineering methods are critical for future surgical
advancements.
A FORMAÇÃO CONTINUADA DE PROFESSORES NA REDE MUNICIPAL DE VÁRZEA GRANDE: UM PACTO PELA ALFABETIZAÇÃO
Authors: Vasconcelos de Almeida Laura Isabel Marques , Santi dos Santos Liliane
Published: November 2022

Este artigo refere-se a Pesquisa de Mestrado em andamento e objetiva identificar as contribuições do Pacto Nacional pela Alfabetização na Idade Certa (PNAIC) na formação continuada de professores das escolas públicas municipais de Várzea Grande. Com abordagem qualitativa, o estudo analisou os documentos oficiais, Cadernos de Formação, arquivos pessoais e depoimentos de protagonistas que participaram efetivamente das ações formativas do PNAIC na rede municipal de ensino. Os dados indicam que as ações formativas possibilitaram identificar as contribuições do Programa para formação continuada de professores que atuam nos Anos Iniciais, oportunizando o compartilhamento de experiências e o crescimento pessoal e profissional dos cursistas. As análises evidenciam que além de exigir do cursista comprometimento, os conteúdos das áreas de Linguagem/Alfabetização e Alfabetização Matemática provocaram impactos positivos na forma de ensinar, indicando que foram empregadas metodologias diversas, com indícios de acompanhamento e monitoramento das atividades desenvolvidas em sala de aula.
Cardiac considerations during COVID-19 pandemic; a cross-sectional study
Authors: Zakaria Ossama , Alarfaj Maryam , Alarfaj Atikah , Alwadani Muhannad , Alwadani Abdullah , Alkhalifah Mohammed
Published: November 2022

Background: Coronavirus disease 2019 (COVID-19) pandemic has a negative impact on the population and especially on those with chronic diseases like diabetes mellitus, hypertension, or heart conditions. This study aimed to evaluate the relation between COVID-19 infection and cardiac diseases. Also, the knowledge and perception of doctors toward the extra protective measures were assessed to put in consideration for those patients.
Methods: A cross sectional study was conducted through an online questionnaire, distributed among cardiac physicians in Saudi Arabia. The applied questionnaire included questions to determine the physician's demographical data such as gender, place of practice, specialty, and experience level.
Results: The participants were fully aware of the effects of COVID-19 on cardiac patients. Around 85% of the physicians believed that COVID-19 could affect the heart. It was found that 77% and 59% of physicians believed that patients could have a higher risk of severe disease resulting from COVID-19 with hypertension and previous heart attack, respectively. Also, 93% of physicians believed that chronic cardiac patients who were COVID- 19 positive might show breathlessness, chest pain, and fatigue. When the participants were asked about anticoagulant therapy, it was found that 60% of physicians preferred to use a combination of anticoagulant drugs. All participants rated hand hygiene as an important preventive measure against COVID-19. Approximately 55% of participants were unfamiliar with the ministry of health (MOH) hand h ygiene guidelines.
Conclusion: Saudi physicians have a higher percentage of knowledge about the relationship between cardiac diseases and COVID-19 infection but further studies must be conducted for more reliable results.
Prevalence and characteristics of non-carious cervical lesions at the Ouagadougou Municipal Oral Health Center, Burkina Faso
Authors: Kaboré Wendpoulomdé Aimé Désiré , Garé Jocelyne Valérie Wenkouni , Ndiaye Diouma , Kouakou Kouadio Florent , Da Koundaviel , Faye Babacar
Published: November 2022

Objectives:

This work sought to study the prevalence of non-carious cervical lesions (NCCLs) in a Burkinabe population consulting at the Municipal Oral Health Center of Ouagadougou.

Material and Methods:

This was a descriptive cross-sectional study. It was carried out between August 1, 2020, and October 31, 2020. The study population consisted of all adult patients regardless of the reason for consultation. The diagnoses of abrasion, erosion, and abfraction were based on the morphology of the clinical forms of each of these lesions as already described in the literature.

Results:

During the study period, 595 patients were examined and 82 of them had at least one NCCL, for an overall prevalence of 13.8%. Abrasion lesions were the encountered the most (47.4%), followed by abfractions (27.1%) and erosions diagnosed in 25.5% of cases.

Conclusion:

NCCLs are pathologies of the neck of the tooth that is of great concern both in terms their clinical and etiological diagnosis as well as their therapy. The prevalence reported in this study is of importance to all oral health professionals, who need to be well aware that NCCL is increasingly a major reason for seeking care.
Effect of caries excavation by Carisolv and SmartPrep burs on dentin hardness — An in vitro study
Authors: Mohan Ishyani , Saju Meenu Elizabeth , Julia Ancy , Raghu Ramya , Shetty Ashish , Souparnika D. P.
Published: November 2022

Objective:

The purpose of this study was to comparatively evaluate two caries excavation methods-Smartprep(SS White) burs and Carisolv (Carisolv™) by measuring the Vickers hardness of prepared cavity.

Materials and Methods:

40 extracted human molars with moderate occlusal caries were used in this study. Teeth with moderate caries extending till dentin without pulp involvement were selected. RVG was used to assess the depth of the cavity. The samples were divided into 2 groups, Group I by Smart prep burs and Group II using Carisolv. Each groups were subjected to morphological analysis under scanning electron microscope.

Results:

The samples prepared with Carisolv showed least difference in hardness values between the prepared surface and surrounding dentin compared to Smartprep burs. SEM analysis with Smartprep burs revealed surface covered with debris and smear layer while Carisolv showed rough and scaly surface with large areas with open dentinal tubules.

Conclusion:

Removal of infected carious dentin was superior when Carisolv was employed as compared to SmartPrep burs. The results concluded that smear layer removal of Carisolv was superior when compared to SmartPrep burs.
Золотодобывающая отрасль Магаданской области в условиях санкций: риски для региона
Authors: Гальцева Н.В.
Published: November 2022

Введение очередного пакета санкций в связи с началом военной операции на Украине особенно сильно меняет условия функционирования в секторах, ориентированных на внешний рынок. К таковым относится золотодобывающая отрасль, использующая высокопроизводительную зарубежную технику на добыче и реализующая продукцию на мировом рынке. Рассмотрены факторы, осложняющие работу отрасли на современном этапе и ведущие к увеличению себестоимости производства и снижению цены реализации золота: применение санкций к крупнейшим банкам-партнерам недропользователей, запрет зарубежными странами на приобретение российского золота и на ввоз импортного оборудования и запасных частей, снижение курса доллара к рублю. На примере конкретного предприятия в Магаданской области выполнена оценка эффективности добычи россыпного золота в изменившихся в условиях. Предложены меры федерального и регионального уровня, способные сгладить остроту возникших проблем в отрасли и последствий для экономики моноресурсного северного региона.
Motivational Elements of Online Knowledge Sharing Among Employees: Evidence from the Banking Sector
Authors: Jameel Alaa S. , Massoudi Aram Hanna , Ahmad Abd Rahman
Published: November 2022

This study aims to examine the impact of self-efficacy, reputation, reci- procity, altruism, and enjoyment on the online knowledge sharing among employees. The study was conducted in the banking sector. The data were collected from four private banks. Smart-PLS., was applied to analyzed 187 valid questionnaires. The results indicated that self-efficacy, reputation, reciprocity, altruism, and enjoy- ment have a positive and significant impact on online knowledge sharing among bank employees. Therefore, banks should establish a conducive online knowledge- sharing environment to encourage reciprocal connections and interpersonal interac- tions among employees. Employees that actively participate in knowledge exchange are encouraged, which help in stimulating the reciprocal online knowledge sharing behavior. The comprehensive model of this study proposes to measure online knowl- edge sharing in the Banking Sector. The present literature does not take into account such a broad perspective.
Monitoring and study of bio-ecological aspects of the citrus borer, Diploschema rotundicolle (Coleoptera:Cerambycidae), in southern-Uruguay lemon orchards
Authors: Amorós María Eugenia , Lagarde Lautaro , Poloni Valentina , González Andrés
Published: November 2022

The citrus borer, Diploschema rotundicolle, is a South American cerambycid beetle considered a primary citrus pest in Uruguay. Serious focalized population explosions have been registered in recent years, particularly in lemon orchards. The larvae feed on the woody tissue, causing tree deterioration and reducing grove productivity and value. Current management relies on cultural control, which is expensive and ineffective partially because of imprecise timing of interventions. Monitoring tools for adults or information of their flight periods in Uruguay are not available thus far. Working in lemon groves in southern Uruguay throughout four flight seasons (2015-2020), we used cross-vane traps coupled with white light devices to capture night-flying adults, and mesh covers around infested trees to study adult emergence. Visual observation of larval activity and oviposition damage were also performed throughout the year. Finally, Eucalyptus globulus windbreaks were checked underneath loosen barks for hidden adults. Throughout all four seasons, adult flight occurred between late January and early April, with a maximum around mid-February. Emergence from mesh-covered trees was observed in the same period. In general, oviposition damage was observed closely after the peak of adult catches. Mostly females were both trapped in light traps and emerged from infested trees. Larval activity was registered all year long. Adults were found sheltered under E. globulus barks; in this case, mostly individual males or couples were found. This study provides a monitoring tool for D. rotundicolle adult flight and information on bio-ecological aspects of this pest in southern Uruguay.
SNP arrays evaluation as tools in genetic improvement in Corriedale sheep in Uruguay
Authors: Carracelas Beatriz , Navajas Elly Ana , Vera Brenda , Ciappesoni Gabriel
Published: November 2022

One control strategy for gastrointestinal nematodes (GIN) is genetic selection. This study´s objective was to compare eggs per gram of feces (FEC) and fiber diameter (FD) estimated breeding values (EBV) and genomic EBV (GEBV) in Corriedale breed. Analysis included 19547 lambs with data, and 454, 711 and 383 genotypes from 170, 507 and 50K SNP chips, respectively. A univariate animal model was used for EBV and GEBV estimation, which included contemporary group, type of birth and dam age as fixed effects, and age at recording as covariate. Differential weights (α) were considered in the genomic relationship matrix (G), and the best fit models were identified using Akaike´s Information Criterion (AIC), which were later used for GEBV and accuracies estimation. The use of α only impacted on low density SNP chips. No differences were observed in mean accuracies for the whole population. However, in the genotyped subgroup accuracies increased by 2% with the 170 SNP chip (α=0.25), and by 5% (α=0.5) and 14% (α=0.75) with the 507 SNP chip. No differences were observed in FD EBV and GEBV mean accuracies. These results show that it is possible to increase GEBV accuracies despite the use of low-density chips.
TRANSPORT SYSTEM OF AFGHANISTAN: STATE AND PROSPECTS
Authors:   Institute of oriental studies, Russian academy of sciences (MOSCOW), Okimbekov Ubaid
Published: November 2022

The article is dedicated to the issues of the state and development of the Afghan land transport network during the period between the collapse and the re-coming to power of the Taliban (2001–2021). It outlines the main achievements of the transport system, the role of international donors in its development, the factors that prevented the achievement of the desired outcomes, the prospects for the development of the industry, taking into account the current political situation.
IT SERVICES SECTOR EVOLUTION IN INDIA AND “DIGITAL INDIA” STRATEGY
Authors:   Institute of oriental studies, Russian academy of sciences (MOSCOW), Tsvetkova Nina
Published: November 2022

Since 1990-s India has attained in the global system of international division of labour a role of computer services and business processes outsourcing center. The paper shows the place of India in world exports of computer services. It characterizes the evolution of IT services sector, (including both computer services and business process outsourcing, actually called business process management, BPM), the role of transnationals and largest Indian companies that have also become TNCs. The focus is also on startups that become unicorns as their market capitalization exceeds 1 billion dollars. Some results of “Digital India” strategy are shown.
BENEFICIOS DEL DESARROLLO DE LA FUERZA Y LA RESISTENCIA EN EL MEDIO ACUÁTICO
Authors: Herrera Rodríguez Manuel Andrés , Ernesto Avella Rafael
Published: November 2022

Existen investigaciones que demuestran que los beneficios obtenidos en el medio acuático son similares a los alcanzados en tierra, aspectos como el gasto calórico que alcanza índices 1 – 2 Kcal/min comprueban dicha relación. Los movimientos globales utilizados en el medio acuático reclutan un mayor número de grupos musculares, por lo que se favorece la capacidad aeróbica al presentar un gasto de oxígeno mayor, que por consecuencia no solo influirá en las células musculares y la capacidad de resistencia aeróbica y anaeróbica, sinotambién, influirá sobre el corazón, los pulmones y el sistema vascular. Al ser la pérdida de calor 25 veces mayor en el medio acuático con respecto al terrestre, se verá facilitada la termorregulación favoreciendo a aquellas personas que no están acostumbradas a la sudoración excesiva y el aumento de la temperatura experimentada en el entrenamiento físico. Como una actividad más agradable se puede definir al acondicionamiento en el medio acuático, porque favorece la percepción de movimientos creando la noción de un esfuerzo más liviano, que otras más intensas realizadas en el medio terrestre, otro de los grandes beneficios de este trabajo es la disminución y casi ausencia de las lesiones, este es un beneficio extra que no pueden brindar otros trabajos, al igual que las personas con problemas de sobrepeso u obesidad ven disminuido su peso en el agua, lo que permite su inclusión en los programas de entrenamiento.
Religious and Spiritual Development from Adolescence to Early Adulthood in the U.S.: Changes over Time and Sexual Orientation Differences
Authors: Lamb Kalina M. , Stawski Robert S. , Dermody Sarah
Published: November 2022

Adolescence is a critical time in the U.S. for religious development in that many young people eschew their religious identity as they enter adulthood. In general, religion is associated with a number of positive health outcomes including decreased substance use and depression. The current study compared the developmental patterns of religiosity and spirituality in heterosexual and sexual minority youth. The design was a secondary data analysis of the first five waves of the Longitudinal Study of Adolescent Health and Wellness (N = 337, 71.8% female). Using multilevel linear (for spirituality) and quadratic (for religiosity) growth models, the initial level and change over time in religiosity and spirituality, as well as the correlations between growth processes, were compared between heterosexual and sexual minority individuals. The heterosexual group had significantly higher initial religiosity levels than the sexual minority group. Religiosity decreased over time at a similar rate for the heterosexual and sexual minority groups. Spirituality significantly increased over time for the sexual minority group but not for the heterosexual youth. The change over time in religiosity and spirituality were significantly and positively correlated for heterosexual individuals but were uncorrelated for sexual minority individuals. Results indicate there are differences in religious development based on sexual minority status. Future research should take into account how these differential religious and spiritual developmental patterns seen in heterosexual and sexual minority youth might predict various health outcomes.
Substantiating the Strategic Directions of Development of the Woodworking Industry of the World Countries
Authors:   Research Centre of Industrial Problems of Development of NAS of Ukraine, Kriachko Yevhen M. , Perepelitsyn Hryhorii B. ,   Research Centre of Industrial Problems of Development of NAS of Ukraine
Published: November 2022

To determine the strategic directions of development of the woodworking industry of the country, a structural-logical scheme of scientific research is proposed, which includes the following stages: identification of the main substantive determinants of ensuring the development of the woodworking industry of the countries over the world; assessment of raw material potential and competitiveness of the woodworking industry of the world countries; modeling the impact of raw materials potential on the competitiveness of the woodworking industry in the countries of the world; determination of priority directions of development of the woodworking industry of these countries. An integral assessment of the raw material potential of the woodworking industry of the world countries was carried out by the following components: forest cover of the territory, reserves of the forest stand, the total volume of wood production, the volume of production of business wood, which made it possible to determine the level and disproportions of the development of raw materials for the woodworking industry of the countries of the world. According to the value of the integral indicator of the raw material potential of the woodworking industry in 2020, from 36 countries chosen, Finland, Canada, Sweden, Latvia, Estonia were included in countries with a high level of raw material potential of the woodworking industry, while the countries with the lowest level were Greece, Mexico, Italy, China, the Netherlands, and Ukraine. The level of competitiveness of the woodworking industry of Ukraine and the world countries is assessed. The leading countries in terms of competitiveness of the woodworking industry in 2020 included Brazil, Russia, Ukraine, Canada, Finland, while the countries with a low level of competitiveness of the woodworking industry included the Netherlands, Greece, Great Britain, Korea, Japan, and Italy. The carried out analysis allows to recommend for the group of leading countries in terms of competitiveness of the woodworking industry (including Ukraine) to focus on increasing exports of woodworking goods with high added value, such as sheet wood materials. A modeling of the influence of raw material potential on the level of competitiveness of the woodworking industry of the world countries is fulfilled. It is determined that the strategic directions of development of the woodworking industry of the countries of the world are to increase the output of products with high added value and the introduction of measures for the rational use of forest resources.
Dominant Impact of Structural Transformation of the Economy of Ukraine on the Efficiency of the Investment Potential Development of Enterprises under Conditions of Uncertainty
Authors:   Ukrainian Engineering and Pedagogical Academy, Prokhorova Viktoriia V. , Yukhman Yaryna V. ,   National University «Lviv Polytechnic»
Published: November 2022

The article defines that the structural transformation of the economy is of great importance for the state, it determines the potential of its long-term development, as a result of which it becomes a strategic factor of general development not only for enterprises of a certain industry, but also for the country as a whole. That is why the structural transformation of Ukraine's economy has a dominant effect on the effectiveness of the development of the investment potential of all industrial enterprises, since today there is a decline in production, which directly depends on the latest innovative measures of the state's strategic development. On the basis of the structural priorities of the socio-economic development of Ukraine and the existing scientific, technical and innovative potential of the domestic economic sector, with the aim of ensuring competition in the scientific sphere, effective concentration of material, technical and financial resources to solve current problems in the economic sector of Ukraine, it is necessary to form long-term innovative programs in general industry in market conditions of management, where the main aspects of scientific and innovative activity of industrial enterprises are indicated. To date, in the economic field, innovations are not implemented very efficiently at effective industrial enterprises. It was concluded that the insufficient amount of financial and economic resources is one of the main reasons preventing the development of new types of products and technologies in the process of implementing innovative developments on the territory of our country. Financial institutions are reluctant to lend to risky innovative projects, and the existing financial and credit mechanism is imperfect and ensures the implementation of the results of applied scientific research in the domestic market and in the markets of developed countries of the world, where credit institutions are created with the participation of state authorities in order to provide guarantees, reducing the amount of use budgetary funds and distributing the risk between the borrower, the bank and the guarantor for the financing of innovative programs and the implementation of innovative projects. The development of industry on an innovative and scientific basis requires the training of a new generation of researchers and highly qualified specialists, ready to carry out innovative activities in market conditions.
Targeting glutaminase is therapeutically effective in ibrutinib-resistant mantle cell lymphoma
Authors: Li Lingzhi , Nie Lei , Jordan Alexa , Cai Qingsong , Liu Yang , Li Yijing , Che Yuxuan , Vargas Jovanny , Chen Zhihong , Leeming Angela , Wang Wei , Yao Yixin , Wang Michael , Jiang Vivian Changying
Published: November 2022

Mantle cell lymphoma (MCL) is an incurable B-cell non-Hodgkin lymphoma characterized by frequent relapses. The development of resistance to ibrutinib therapy remains a major challenge in MCL. We previously showed that glutaminolysis is associated with resistance to ibrutinib. In this study, we confirmed that glutaminase (GLS), the first enzyme in glutaminolysis, is overexpressed in ibrutinib-resistant MCL cells, and that its expression correlates well with elevated glutamine dependency and glutaminolysis. Furthermore, we discovered that GLS expression correlates with MYC expression and the functioning of the glutamine transporter ASCT2. Depletion of glutamine or GLS significantly reduced cell growth, while GLS overexpression enhanced glutamine dependency and ibrutinib resistance. Consistent with this, GLS inhibition by its specific inhibitor telaglenastat suppressed MCL cell growth both in vitro and in vivo. Moreover, telaglenastat showed anti-MCL synergy when combined with ibrutinib or venetoclax in vitro, which was confirmed using an MCL patient-derived xenograft model. Our study provides the first evidence that targeting GLS with telaglenastat, alone or in combination with ibrutinib or venetoclax, is a promising strategy to overcome ibrutinib resistance in MCL.
Sistem Pakar Rekomendasi Tanaman Herbal Berdasarkan Faktor Lingkungan Menggunakan Metode Certainty Factor
Authors: Khaira Ulfa , Aulia Bisma , Musfiroh Desi
Published: November 2022

Tren bertani dikala pandemi saat ini digemari oleh masyarakat, terlebih tanaman herbal. Sehingga masyarakat banyak mengikuti tren tersebut. Akan tetapi, masyarakat perlu ilmu dalam bertani tersebut. Dalam pembibitannya, tanaman herbal memiliki karakteristik dan perlakuan lingkungan yang berbeda-beda. Sehingga diperlukan pengetahuan yang baik terkait proses pembibitan tanaman tersebut. Konsultan pertanian dibutuhkan untuk memberikan rekomendasi tanaman herbal apa yang cocok sesuai dengan faktor lingkungan. Melalui sistem pakar, masyarakat dapat mengetahui informasi yang baik dan benar seperti dari pakar langsung.  Dalam penelitian ini, sistem pakar rekomendasi tanaman herbal dibangun untuk membantu memberikan rekomendasi tanaman herbal yang cocok ditanam berdasarkan faktor lingkungan. Faktor-faktor lingkungan yang digunakan untuk dasar rekomendasi adalah ketinggian wilayah, suhu, kelembapan udara, curah hujan, dan jenis tanah. Pada penelitian ini sampel akuisisi pengetahuan tanaman herbal yang digunakan adalah 12 jenis. Metode yang digunakan pada sistem pakar ini adalah metode certainty factor. Melalui metode certainty factor akan membantu  menangani ketidakmampuan pakar dalam mendefinisikan antara sebuah aspek lingkungan dengan tanaman yang cocok ditanam secara pasti.  Dengan memilih faktor lingkungan yang dilihat maka sistem dapat merekomendasi tanaman herbal dengan  nilai certainty factor terbesar. Hasil dari penelitian ini dapat memberikan masyarakat informasi rekomendasi tanaman yang cocok untuk lokasi daerah mereka serta memberikan tingkat keyakinannya.
Fuzzy logic control of five-DOF active magnetic bearing system based on sliding mode concept
Authors: Saha Sudipta , Amrr Syed Muhammad , Bhutto Javed Khan , AlJohani Anas Ayesh , Nabi M.
Published: November 2022

In rotor dynamics, the deviation of the shaft is a common phenomenon. The main reasons for the deviation are non-linear attractive forces, harmonic disturbances, system parameter variations, etc. Active magnetic bearings (AMBs) are used to support the rotor inside the air gap in rotating machines, thus avoiding wear and tear and possible breakdowns. This paper proposes a fuzzy sliding mode-inspired control (FSMIC) technique for the five-degrees-of-freedom (DOF) AMB system in the presence of system uncertainties and measurement noises. The fuzzy logic is used to estimate the auxiliary control input of the sliding mode control (SMC) to attenuate the chattering. The variable gains are designed with the help of superintended fuzzy logic to bring more flexibility to the controller performance. The stability analysis is presented with the help of the Lyapunov function candidate. The simulation studies for the AMB system under distinct types of control techniques, i.e., PID, SMC, and FSMIC, illustrate the effectiveness of the proposed control strategy.
Thermally conductive electro-osmotic propulsive pressure-driven peristaltic streaming flow study with a suspended nanomaterial in a micro-ciliated tube
Authors: Butt Adil Wahid , Akbar Noreen Sher , Mehmood Rashid , Farooq Shahid
Published: November 2022

This article focuses on the peristaltic flow of carbon nanoparticle-suspended nanofluids under the influence of electroosmosis. The flow is considered inside a vertical tube with ciliated boundary walls. This study holds great importance because it represents the flow inside the esophagus of the human body. Nanoparticles are inserted in blood for diagnosing diseases like cancer and are also useful in angiography, angioplasty, etc. A comparative study is conducted for single-walled carbon nanotubes and multi-walled carbon nanotubes. We used the analytical method to obtain exact solutions of the velocity, temperature, and pressure profiles. The results have been presented graphically. Streamlines are also plotted to visualize the difference with SWCNT and MWCNT. We found that the use of CNT in the base fluid significantly enhances the thermal conductivity and helps increase the velocity of the fluid.
Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study
Authors: Bruni Andrea , Longhini Federico , Macheda Sebastiano , Biamonte Eugenio , Pasqua Pino , Neri Giuseppe , Guzzo Maria Laura , Garofalo Eugenio ,   Calabria COVID-ICU Network authors
Published: November 2022

Introduction

After the rapid surge of a novel coronavirus (SARS-CoV-2) in 2020 anti-SARS-CoV-2 vaccines have been developed to prevent the development of critical forms of COVID-19 leading to Intensive Care Unit (ICU) admission. The possibility of ICU admission after the first-cycle vaccination has been already reported; however, no data have been published regarding vaccinated patients with a “booster” dose. This retrospective study describes the characteristics of critically ill patients after the implementation of the regional “booster” dose vaccination program in a southern region of Italy.

Materials and methods

We screened all medical records of critically ill COVID-19 patients in the period between January to April 2022. We collected the demographic characteristics, the presence of comorbidities, the vaccination status, the clinical course (arterial blood gases and type of respiratory support) and outcomes (rate of tracheostomy, ICU length of stay and mortality).

Results

A total of 272 patients were admitted to ICUs during the study period. 161 patients were unvaccinated, whereas 111 were vaccinated with the complete first-cycle or “booster” dose. The type of respiratory support was similar between groups. Vaccinated patients were characterized by a better oxygenation throughout the whole ICU length of stay. Fourteen unvaccinated and 3 vaccinated patients required tracheostomy (p = 0.045). ICU length of stay was 12.2 (± 7.3) days in unvaccinated patients and 10.4 (± 6.7) days in vaccinated patients (p = 0.036). ICU mortalities were 38.5 and 24.3% in unvaccinated and vaccinated patients, respectively (p = 0.014).

Conclusion

Vaccinated patients have better clinical course and outcomes as compared to the unvaccinated population.
A triple-step controller with linear active disturbance rejection control for a lower limb rehabilitation robot
Authors: Peng Huanfeng , Zhou Jie , Song Rong
Published: November 2022

Lower limb rehabilitation robots (LLRRs) have shown promising potential in assisting hemiplegic patients to recover their motor function. During LLRR-aided rehabilitation, the dynamic uncertainties due to human-robot coupling, model uncertainties, and external disturbances, make it challenging to achieve high accuracy and robustness in trajectory tracking. In this study, we design a triple-step controller with linear active disturbance rejection control (TSC-LADRC) for a LLRR, including the steady-state control, feedforward control, and feedback control. The steady-state control and feedforward control are developed to compensate for the gravity and incorporate the reference dynamics information, respectively. Based on the linear active disturbance rejection control, the feedback control is designed to enhance the control performance under dynamic uncertainties. Numerical simulations and experiments are conducted to validate the effectiveness of TSC-LADRC. The results of simulations illustrate that the tracking errors under TSC-LADRC are obviously smaller than those under the triple-step controller without LADRC (TSC), especially with the change of external loads. Moreover, the experiment results of six healthy subjects reveal that the proposed method achieves higher accuracy and lower energy consumption than TSC. Therefore, TSC-LADRC has the potential to assist hemiplegic patients in rehabilitation training.
Machine learning approach for hemorrhagic transformation prediction: Capturing predictors' interaction
Authors: Elsaid Ahmed F. , Fahmi Rasha M. , Shehta Nahed , Ramadan Bothina M.
Published: November 2022

Background and purpose

Patients with ischemic stroke frequently develop hemorrhagic transformation (HT), which could potentially worsen the prognosis. The objectives of the current study were to determine the incidence and predictors of HT, to evaluate predictor interaction, and to identify the optimal predicting models.

Methods

A prospective study included 360 patients with ischemic stroke, of whom 354 successfully continued the study. Patients were subjected to thorough general and neurological examination and T2 diffusion-weighted MRI, at admission and 1 week later to determine the incidence of HT. HT predictors were selected by a filter-based minimum redundancy maximum relevance (mRMR) algorithm independent of model performance. Several machine learning algorithms including multivariable logistic regression classifier (LRC), support vector classifier (SVC), random forest classifier (RFC), gradient boosting classifier (GBC), and multilayer perceptron classifier (MLPC) were optimized for HT prediction in a randomly selected half of the sample (training set) and tested in the other half of the sample (testing set). The model predictive performance was evaluated using receiver operator characteristic (ROC) and visualized by observing case distribution relative to the models' predicted three-dimensional (3D) hypothesis spaces within the testing dataset true feature space. The interaction between predictors was investigated using generalized additive modeling (GAM).

Results

The incidence of HT in patients with ischemic stroke was 19.8%. Infarction size, cerebral microbleeds (CMB), and the National Institute of Health stroke scale (NIHSS) were identified as the best HT predictors. RFC (AUC: 0.91, 95% CI: 0.85–0.95) and GBC (AUC: 0.91, 95% CI: 0.86–0.95) demonstrated significantly superior performance compared to LRC (AUC: 0.85, 95% CI: 0.79–0.91) and MLPC (AUC: 0.85, 95% CI: 0.78–0.92). SVC (AUC: 0.90, 95% CI: 0.85–0.94) outperformed LRC and MLPC but did not reach statistical significance. LRC and MLPC did not show significant differences. The best models' 3D hypothesis spaces demonstrated non-linear decision boundaries suggesting an interaction between predictor variables. GAM analysis demonstrated a linear and non-linear significant interaction between NIHSS and CMB and between NIHSS and infarction size, respectively.

Conclusion

Cerebral microbleeds, NIHSS, and infarction size were identified as HT predictors. The best predicting models were RFC and GBC capable of capturing nonlinear interaction between predictors. Predictor interaction suggests a dynamic, rather than, fixed cutoff risk value for any of these predictors.
Sichuan dark tea improves lipid metabolism and prevents aortic lipid deposition in diet-induced atherosclerosis model rats
Authors: Lu Rui , Sugimoto Takumi , Tsuboi Tomoe , Sekikawa Tatsushi , Tanaka Mamoru , Lyu Xiaohua , Yokoyama Shinji
Published: November 2022

Background and aims

Sichuan dark tea (ST), Zangcha, is a traditional fermented Chinese tea found in Sichuan and Tibet and claimed for beneficial effects against lifestyle-related metabolic disorders. We examined the effects of ST on lipid metabolism and atherosclerosis.

Methods and results

Sichuan dark tea was given to fat-rich diet-induced atherosclerosis model rats in comparison with dark-fermented Chinese Pu-erh tea (PT) and Japanese green tea (GT). After 8 weeks of feeding, ST and PT induced an increase in high-density lipoprotein (HDL)-cholesterol and a decrease in glucose, and ST decreased triglyceride in plasma. ST also induced low pH in the cecum. There was no significant change in their body weight among the fat-feeding groups but a decrease was found in the visceral fat and liver weight in the ST group. Accordingly, ST reduced lipid deposition in the aorta in comparison with PT and GT. ST increased mRNA of LXRα, PPARα, PPARγ, and ABCA1 in the rat liver. The extract of ST stimulated the AMPK pathway to increase the expression of ABCA1 in J774 cells and increased expression of lipoprotein lipase and hormone-sensitive lipase in 3T3L1 cells, consistent with its anti-atherogenic effects in rats. High-performance liquid chromatography analysis showed unique spectra of original specific compounds of caffeine and catechins in each tea extract, but none of them was likely responsible for these effects.

Conclusion

Sichuan dark tea increases plasma HDL and reduces plasma triglyceride to decrease atherosclerosis through AMPK activation. Further study is required to identify specific components for the effects of this tea preparation.
The association between duration of muscle exercise and psychological symptoms is higher in boys than in girls: A cross-sectional study based on Chinese college students during COVID-19
Authors: Ouyang Yu , Hong Yu , Cheng Jun , Cao Hongmin
Published: November 2022

Objective

The COVID-19 pandemic has had many negative effects on the physical and mental health of college students. Although many studies have analyzed the association between muscular fitness and psychological symptoms in children and adolescents, research during the COVID-19 pandemic is limited. Our study focused on analyzing the association between duration of muscle exercise and psychological symptoms among Chinese college students during the COVID-19 pandemic.

Method

A four-stage stratified whole-group sampling method was used to investigate basic demographic information, duration of muscle exercise and psychological symptoms in 5,559 college students aged 19–22 years in China. Chi-square test (categorical variables) and one-way ANOVA (continuous variables) were used to compare the psychological symptoms of college students with different durations of muscle exercise. Logistic regression analysis was used to analyze the association between duration of muscle exercise and psychological symptoms.

Result

The detection rate of psychological symptoms among Chinese college students was 9.0%; the detection rate was 10.7% for boys and 7.6% for girls. The proportions of duration of muscle exercise at <30 min/d, 30–60 min/d, and >60 min/d were 75.0%, 20.4%, and 4.6%, respectively. After adjusting for relevant confounding variables, taking Chinese college students with duration of muscle exercise >60 min/d as the reference group, duration of muscle exercise <30 min/d was positively correlated with the occurrence of psychological symptoms (OR: 4.19, 95%CI: 1.82, 9.61) (P < 0.001). In emotional symptoms (OR: 4.56, 95%CI: 1.99, 10.44), behavioral symptoms (OR: 3.44, 95%CI: 1.79, 6.60), social adaptation difficulties (OR: 3.04, 95%CI: 1.62, 5.68) dimensions, there is also a positive correlation (P < 0.01).

Conclusions

The negative association between duration of muscle exercise and psychological symptoms among Chinese college students also suggests that longer duration of muscle exercise among college students is associated with a lower prevalence of psychological symptoms. The association between duration of muscle exercise and psychological symptoms was higher in boys compared to girls.
Case report: Severe acute hepatitis in a 22-month-old Chinese boy with Omicron sub-variant BA.2.38
Authors: Chen Xinying , Hong Junbin , Li Yuxia , An Caixia , Guo Jianwen , Yang Jinghua
Published: November 2022

The etiology of severe acute hepatitis (SAH) in children is various. We describe the first Chinese case of severe acute hepatitis in a 22-month-old boy with the mild illness of Omicron sub-variant BA.2.38. With the application of Compound Glycyrrhizin Injection (CGI), the patient gradually recovered from acute liver injury (ALI). This case highlights the possibility of severe ALI in children with the non-critical illness of SARS-CoV-2. The management of SAH associated with the pandemic presents challenges for clinicians, and follow-up is in need. The method of differential diagnosis using limited laboratory results is of great value to the clinicians.