bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Study on the Behavior of Aluminum Fuse Element Inside 24 kV, 50 kA High-Voltage Fuses
Authors: Sălceanu Cristian-Eugeniu , Nicola Marcel , Nicola Claudiu-Ionel , Ocoleanu Daniel , Dobrea Cătălin , Iovan Daniela , Enache Sorin
Published: September 2022

High-voltage fuses are found in most electrical installations, where they are used for overcurrent protection and are the pieces of equipment providing the highest degree of protection for the lowest initial cost. This article focuses on the behavior of high-voltage fuses containing a fuse element entirely made of aluminum. We made high-power linear electrical circuits for experiments on these fuses under the most severe operating conditions. The article presents the construction details of the fuse element and its features, as well as various arc extinguishing media. The heating behavior and time–current characteristics were studied in comparison with fuses made of copper. We obtained the maximum instantaneous value of the current reached during interruption for a 24 kV, 50 kA, 50 A fuse, as well as the value of the minimum breaking current.
Theoretical Investigations on Shadow Band Correction Factors for Diffuse Radiation under Isotropic Conditions without Approximation
Authors: Cheng Haiying , Zhang Xuan , Chen Ziqian , Sun Wenhong , He Kaiyan , Zheng Hongfei , Tang Yanxiu
Published: September 2022

The precise measurement for irradiance is important for the performance evaluations of solar systems, because both beam and diffuse radiation measurements must be known to calculate the efficiency of a solar system. One of the widely used instruments for diffuse radiation measurement is a pyranometer with a ring. Hence, investigations on shadow band correction factors are necessary. The factors are normally calculated by the expressions of Drummond and Burek et al. under isotropic conditions. However, their calculation results are approximate. While the latitude φ, the inclination angle β and the declination δ are satisfied with the condition of |−tan(φ−β)tanδ|>1, the factors cannot be calculated by their expressions. In this paper, the expressions for the factors under isotropic conditions were obtained by coordinate transformations and discussed in two different coordinate systems without approximation. Our expressions can give precise correction factors in any case and overcome the disadvantages of their expressions. While the sensor is placed horizontally, the maximum relative deviation between the results by the expression in Drummond’s paper and by our expressions is less than 2.3%. When the sensor is placed on a sloped surface, the results by the expressions in Burek’s paper and by our expressions will have considerable differences in some ranges of slope angles and latitudes. The maximum relative deviation is more than 22%.
Simplified Numerical Model for Transient Flow of Slurries at Low Concentration
Authors: Kodura Apoloniusz , Weinerowska-Bords Katarzyna , Kubrak Michał
Published: September 2022

Rapid transients are particularly dangerous in industrial hydro-transport systems, where solid-liquid mixtures are transported via long pressure pipelines. A mathematical description of such flow is difficult due to the complexity of phenomena and difficulties in determining parameters. The main aim of the study was to examine the influence of the simplified mixture density and wave celerity description on satisfactory reproduction of pressure characteristics during the transient flow of slurry at low concentrations. The paper reports and discusses the selected aspects of experimental and numerical analyses of transient slurry flow in a polyethylene pipe. The experiments were conducted by using the physical model of a slurry’s transportation pressure. The aim of the experiments was to determine the wave celerity during a transient flow in slurries. A low concertation of slurries, which was used during experiments, is typical for one of the biggest slurry networks in Poland. A comparison of the effects of different wave celerity descriptions was performed. The research reported that the theoretical formulas for slurry wave celerity and mixture density were not sufficiently accurate to obtain satisfactory compliance between calculations and observations. To improve the model, the experimental values of wave celerity and the concept of equivalent mixture density have been applied to indirectly consider the influence of variable mixture parameters. With such modifications, the calculated pressure characteristics in all analyzed episodes demonstrated satisfactory compliance with observations. The simplified approach proved to be effective in properly reproducing the intensity and frequency of rapid pressure changes.
Exploring the Complementarity of Offshore Wind Sites to Reduce the Seasonal Variability of Generation
Authors: Fernandes Italo , Pimenta Felipe M. , Saavedra Osvaldo R. , Assireu Arcilan T.
Published: September 2022

Wind energy is a powerful resource contributing to the decarbonization of the electric grid. However, wind power penetration introduces uncertainty about the availability of wind energy. This article addresses the complementarity of remote offshore wind sites in Brazil, demonstrating that strategic distribution of wind farms can significantly reduce the seasonality and the risk of periods without generation and reduce dependence on fossil sources. Field observations, atmospheric reanalysis, and simplified optimization methods are combined to demonstrate generation improvement considering regions under environmental licensing and areas not yet considered for offshore development. Aggregated power results demonstrate that with the relocation of wind turbines, a 68% reduction of the grid seasonal variability is possible, with a penalty of only 9% of the generated energy. This is accomplished through optimization and the inclusion of the northern region, which presents negative correlations with all other stations. More specifically, the north and northeast of Brazil have large seasonal amplitudes. However, out-of-phase wind regimes with a strong negative correlation (R < −0.6) and high-capacity factors (CF) during the peak seasons occur in Jan-Feb-Mar in the north (CF > 0.5) and in Aug-Sep-Oct in the northeast (CF > 0.7). These complementary regimes allow for the introduction of the concept of Reserve Wind Power (RWP) plants, wind farms that can be viewed as “reserve sources” for energy security. These can replace the contracts of thermal reserve plants, with resulting economic and environmental advantages. Our analysis suggests that RWP plants can be 20 to 32% cheaper than thermal reserves in the current market.
Fault Diagnosis and Fault Tolerant Control of Wind Turbines: An Overview
Authors: Fekih Afef , Habibi Hamed , Simani Silvio
Published: September 2022

Wind turbines are playing an increasingly important role in renewable power generation. Their complex and large-scale structure, however, and operation in remote locations with harsh environmental conditions and highly variable stochastic loads make fault occurrence inevitable. Early detection and location of faults are vital for maintaining a high degree of availability and reducing maintenance costs. Hence, the deployment of algorithms capable of continuously monitoring and diagnosing potential faults and mitigating their effects before they evolve into failures is crucial. Fault diagnosis and fault tolerant control designs have been the subject of intensive research in the past decades. Significant progress has been made and several methods and control algorithms have been proposed in the literature. This paper provides an overview of the most recent fault diagnosis and fault tolerant control techniques for wind turbines. Following a brief discussion of the typical faults, the most commonly used model-based, data-driven and signal-based approaches are discussed. Passive and active fault tolerant control approaches are also highlighted and relevant publications are discussed. Future development tendencies in fault diagnosis and fault tolerant control of wind turbines are also briefly stated. The paper is written in a tutorial manner to provide a comprehensive overview of this research topic.
Characterization of Rare Himalayan Balsam (Impatiens glandulifera Royle) Honey from Croatia
Authors: Prđun Saša , Flanjak Ivana , Svečnjak Lidija , Primorac Ljiljana , Lazarus Maja , Orct Tatjana , Bubalo Dragan , Bilić Rajs Blanka
Published: September 2022

Himalayan balsam (Impatiens glandulifera Royle) is an invasive garden ornamental plant species originating from Asia, which produces significant amounts of nectar. In Croatia, it is widely distributed along the banks of the Mura River. Although this plant species is widespread in Europe, there are still no available scientific data about this unifloral honey type. The results showed that Himalayan balsam honey is characterized by the high presence of pollen grains in the pollen spectrum (59–85%), natural higher diastase activity (39.1 ± 7.98 DN), negative specific rotation (−21.2° ± 6.89) and an extra light amber color (48.5 ± 12.69 mm Pfund). The carbohydrate profile is characterized by monosaccharides fructose (39.34 ± 0.65 g/100 g) and glucose (31.91 ± 1.42 g/100 g) with a ratio >1.23, while the most commonly represented disaccharide was maltose (3.04 ± 0.79 g/100 g). The average total phenolic content was 130.97 ± 11.17 mg gallic acid/kg honey, and the average antioxidant capacity value was 225.38 ± 29.58 µM Fe(II). The major mineral element was K, with an average of 533.92 ± 139.70 mg/kg. The sensory profile was characteristic with a light orange color and medium-intensity odor and aroma. The crystallization rate was moderate and characterized by the appearance of opalescence and gelatinous forms of crystals. The results of this study provide the first insight into the melissopalynological, physico-chemical and sensory profile of Himalayan balsam honey.
Lightweight 3D-Printed Fractal Gradient-Index Lens Antenna with Stable Gain Performance
Authors: Kim Yeonju , Pham Duc Anh , Phon Ratanak , Lim Sungjoon
Published: September 2022

This paper proposes a millimeter-wave lens antenna using 3-dimensional (3D) printing technology to reduce weight and provide stable gain performance. The antenna consists of a four-layer cylindrical gradient-index (GRIN) lens fed by a wideband Yagi antenna. We designed a fractal cell geometry to achieve the desired effective permittivity for a GRIN lens. Among different candidates, the honeycomb structure is chosen to provide high mechanical strength with light weight, low dielectric loss, and lens dispersion for a lens antenna. Therefore, the measured peak gain was relatively flat at 16.86 ± 0.5 dBi within 25−31.5 GHz, corresponding to 1 dB gain bandwidth = 23%. The proposed 3D-printed GRIN lens is cost-effective, with rapid and easy manufacturing.
cPlot: Contig-Plotting Visualization for the Analysis of Short-Read Nucleotide Sequence Alignments
Authors: Ji Mingeun , Kan Yejin , Kim Dongyeon , Jung Jaehee , Yi Gangman
Published: September 2022

Advances in the next-generation sequencing technology have led to a dramatic decrease in read-generation cost and an increase in read output. Reconstruction of short DNA sequence reads generated by next-generation sequencing requires a read alignment method that reconstructs a reference genome. In addition, it is essential to analyze the results of read alignments for a biologically meaningful inference. However, read alignment from vast amounts of genomic data from various organisms is challenging in that it involves repeated automatic and manual analysis steps. We, here, devised cPlot software for read alignment of nucleotide sequences, with automated read alignment and position analysis, which allows visual assessment of the analysis results by the user. cPlot compares sequence similarity of reads by performing multiple read alignments, with FASTA format files as the input. This application provides a web-based interface for the user for facile implementation, without the need for a dedicated computing environment. cPlot identifies the location and order of the sequencing reads by comparing the sequence to a genetically close reference sequence in a way that is effective for visualizing the assembly of short reads generated by NGS and rapid gene map construction.
Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway
Authors: Subramanian Umadevi , Ramasamy Chandramohan , Ramachandran Samivel , Oakes Joshua M. , Gardner Jason D. , Pandey Kailash N.
Published: September 2022

The global targeted disruption of the natriuretic peptide receptor-A (NPRA) gene (Npr1) in mice provokes hypertension and cardiovascular dysfunction. The objective of this study was to determine the mechanisms regulating the development of cardiac fibrosis and dysfunction in Npr1 mutant mice. Npr1 knockout (Npr1−/−, 0-copy), heterozygous (Npr1+/−, 1-copy), and wild-type (Npr1+/+, 2-copy) mice were treated with the transforming growth factor (TGF)-β1 receptor (TGF-β1R) antagonist GW788388 (2 µg/g body weight/day; ip) for 28 days. Hearts were isolated and used for real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), Western blot, and immunohistochemical analyses. The Npr1−/− (0-copy) mice showed a 6-fold induction of cardiac fibrosis and dysfunction with markedly induced expressions of collagen-1α (3.8-fold), monocyte chemoattractant protein (3.7-fold), connective tissue growth factor (CTGF, 5.3-fold), α-smooth muscle actin (α-SMA, 6.1-fold), TGF-βRI (4.3-fold), TGF-βRII (4.7-fold), and phosphorylated small mothers against decapentaplegic (pSMAD) proteins, including pSMAD-2 (3.2-fold) and pSMAD-3 (3.7-fold), compared with wild-type mice. The expressions of phosphorylated extracellular-regulated kinase ERK1/2 (pERK1/2), matrix metalloproteinases-2, -9, (MMP-2, -9), and proliferating cell nuclear antigen (PCNA) were also significantly upregulated in Npr1 0-copy mice. The treatment of mutant mice with GW788388 significantly blocked the expression of fibrotic markers, SMAD proteins, MMPs, and PCNA compared with the vehicle-treated control mice. The treatment with GW788388 significantly prevented cardiac dysfunctions in a sex-dependent manner in Npr1 0-copy and 1-copy mutant mice. The results suggest that the development of cardiac fibrosis and dysfunction in mutant mice is predominantly regulated through the TGF-β1-mediated SMAD-dependent pathway.
Gut–Brain Axis: Insights from Hippocampal Neurogenesis and Brain Tumor Development in a Mouse Model of Experimental Colitis Induced by Dextran Sodium Sulfate
Authors: Vitali Roberta , Prioreschi Clara , Lorenzo Rebenaque Laura , Colantoni Eleonora , Giovannini Daniela , Frusciante Sarah , Diretto Gianfranco , Marco-Jiménez Francisco , Mancuso Mariateresa , Casciati Arianna , Pazzaglia Simonetta
Published: September 2022

Chronic inflammatory bowel disorders (IBD) are idiopathic diseases associated with altered intestinal permeability, which in turn causes an exaggerated immune response to enteric antigens in a genetically susceptible host. A rise in psych cognitive disorders, such as anxiety and depression, has been observed in IBD patients. We here report investigations on a model of chemically induced experimental colitis by oral administration of sodium dextran sulfate (DSS) in C57BL/6 mice. We investigate, in vivo, the crosstalk between the intestine and the brain, evaluating the consequences of intestinal inflammation on neuroinflammation and hippocampal adult neurogenesis. By using different DSS administration strategies, we are able to induce acute or chronic colitis, simulating clinical characteristics observed in IBD patients. Body weight loss, colon shortening, alterations of the intestinal mucosa and fecal metabolic changes in amino acids-, lipid- and thiamine-related pathways are observed in colitis. The activation of inflammatory processes in the colon is confirmed by macrophage infiltration and increased expression of the proinflammatory cytokine and oxidative stress marker (Il-6 and iNOS). Interestingly, in the hippocampus of acutely DSS-treated mice, we report the upregulation of inflammatory-related genes (Il-6, Il-1β, S-100, Tgf-β and Smad-3), together with microgliosis. Chronic DSS treatment also resulted in neuroinflammation in the hippocampus, indicated by astrocyte activation. Evaluation of stage-specific neurogenesis markers reveals deficits in the dentate gyrus after acute and chronic DSS treatments, indicative of defective adult hippocampal neurogenesis. Finally, based on a possible causal relationship between gut-related inflammation and brain cancer, we investigate the impact of DSS-induced colitis on oncogenesis, using the Ptch1+/−/C57BL/6 mice, a well-established medulloblastoma (MB) mouse model, finding no differences in MB development between untreated and DSS-treated mice. In conclusion, in our experimental model, the intestinal inflammation associated with acute and chronic colitis markedly influences brain homeostasis, impairing hippocampal neurogenesis but not MB oncogenesis.
Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study
Authors: Liu Jingli , Guo Hui , Zhou Jing , Wang Yuwei , Yan Hao , Jin Ruyi , Tang Yuping
Published: September 2022

Evodiamine (EVO) and rutaecarpine (RUT) are the main active compounds of the traditional Chinese medicinal herb Evodia rutaecarpa. Here, we fully optimized the molecular geometries of EVO and RUT at the B3LYP/6-311++G (d, p) level of density functional theory. The natural population analysis (NPA) charges, frontier molecular orbitals, molecular electrostatic potentials, and the chemical reactivity descriptors for EVO and RUT were also investigated. Furthermore, molecular docking, molecular dynamics simulations, and the analysis of the binding free energies of EVO and RUT were carried out against the anticancer target topoisomerase 1 (TOP1) to clarify their anticancer mechanisms. The docking results indicated that they could inhibit TOP1 by intercalating into the cleaved DNA-binding site to form a TOP1–DNA–ligand ternary complex, suggesting that they may be potential TOP1 inhibitors. Molecular dynamics (MD) simulations evaluated the binding stability of the TOP1–DNA–ligand ternary complex. The calculation of binding free energy showed that the binding ability of EVO with TOP1 was stronger than that of RUT. These results elucidated the structure–activity relationship and the antitumor mechanism of EVO and RUT at the molecular level. It is suggested that EVO and RUT may be potential compounds for the development of new anticancer drugs.
The Potential Roles of Myokines in Adipose Tissue Metabolism with Exercise and Cold Exposure
Authors: Jiang Shu , Bae Jun-Hyun , Wang Yangwenjie , Song Wook
Published: September 2022

Exercise and cold exposure are two stimuli that have been suggested as solely effective to modulate adipose tissue metabolism and improve metabolic health in obese populations. The two primary organs involved in energy metabolism during exercise and/or cold exposure are skeletal muscle and adipose tissue. Adipose tissue can be divided mainly into two types: white adipose tissue (WAT), which primarily stores energy, and brown adipose tissue (BAT), known as the primary source of thermogenesis. The exercise-stimulated release of myokines allows for crosstalk between skeletal muscle and adipose tissue, partially mediating the beneficial effects of exercise. Cold exposure is another trigger for the regulation of myokine secretions, thus increasing adipose tissue metabolism, especially via activation of BAT. Therefore, this has generated the hypothesis that exercise in conjunction with cold exposure might be the optimal regimen to regulate myokine profiles and gain more beneficial health effects. However, to date, human experimental data regarding different exercise (frequency, type, time and intensity) and cold exposure (temperature, time and frequency) patterns are scarce. In this review, we will summarize the current human clinical trials investigating the regulation of myokines induced by exercise combined with cold exposure, to elaborate on the roles of myokines in mediating adipose tissue metabolism.
REMD Simulations of Full-Length Alpha-Synuclein Together with Ligands Reveal Binding Region and Effect on Amyloid Conversion
Authors: Semenyuk Pavel I.
Published: September 2022

Alpha-synuclein is a key protein involved in the development and progression of Parkinson’s disease and other synucleinopathies. The intrinsically disordered nature of alpha-synuclein hinders the computational screening of new drug candidates for the treatment of these neurodegenerative diseases. In the present work, replica exchange molecular dynamics simulations of the full-length alpha-synuclein together with low-molecular ligands were utilized to predict the binding site and effect on the amyloid-like conversion of the protein. This approach enabled an accurate prediction of the binding sites for three tested compounds (fasudil, phthalocyanine tetrasulfonate, and spermine), giving good agreement with data from experiments by other groups. Lots of information about the binding and protein conformational ensemble enabled the suggestion of a putative effect of the ligands on the amyloid-like conversion of alpha-synuclein and the mechanism of anti- and pro-amyloid activity of the tested compounds. Therefore, this approach looks promising for testing new drug candidates for binding with alpha-synuclein or other intrinsically disordered proteins and at the same time the estimation of the effect on protein behavior, including amyloid-like aggregation.
Does Antithrombotic Therapy Affect Outcomes in Major Trauma Patients? A Retrospective Cohort Study from a Tertiary Trauma Centre
Authors: Sartini Stefano , Spadaro Marzia , Cutuli Ombretta , Castellani Luca , Sartini Marina , Cristina Maria Luisa , Canepa Paolo , Tognoni Chiara , Lo Agnese , Canata Lorenzo , Rosso Martina , Arboscello Eleonora
Published: September 2022

Antithrombotic therapy may affect outcomes in major trauma but its role is not fully understood. We aimed to investigate adverse outcomes among those with and without antithrombotic treatment in major trauma. Material and methods: This is a retrospective study conducted at the Emergency Department (ED) of the University Hospital of Genoa, a tertiary trauma center, including all major trauma between January 2019 and December 2020. Adverse outcomes were reviewed among those without antithrombotic treatment (Group 0), on antiplatelet treatment (Group 1), and on anticoagulant treatment (Group 2). Results: We reviewed 349 electronic charts for full analysis. Group 0 were n = 310 (88.8%), Group 1 were n = 26 (7.4%), and Group 2 were n = 13 (3.7%). In-hospital death and ICU admission, respectively, were: n = 16 (5.6%) and n = 81 (26%) in Group 0, none and n = 6 (25%) in Group 1, and n = 2 (15.8%) and n = 4 (30.8%) in Group 2 (p = 0.123-p = 0.874). Altered INR (OR 5.2) and increasing D-dimer levels (AUC: 0.81) correlated to increased mortality. Discussion: Group 2 showed higher mortality than Group 0 and Group 1, however Group 2 had fewer active treatments. Of clotting factors, only altered INR and elevated D-dimer levels were significantly correlated to adverse outcomes. Conclusions: Anticoagulant but not antiplatelet treatment seems to produce the worst outcomes in major trauma.
Does Improvement towards a Normal Cervical Sagittal Configuration Aid in the Management of Lumbosacral Radiculopathy: A Randomized Controlled Trial
Authors: Moustafa Ibrahim Moustafa , Diab Aliaa Attiah Mohamed , Harrison Deed Eric
Published: September 2022

A randomized controlled study with a six-month follow-up was conducted to investigate the effects of sagittal head posture correction on 3D spinal posture parameters, back and leg pain, disability, and S1 nerve root function in patients with chronic discogenic lumbosacral radiculopathy (CDLR). Participants included 80 (35 female) patients between 40 and 55 years experiencing CDLR with a definite hypolordotic cervical spine and forward head posture (FHP) and were randomly assigned a comparative treatment control group and a study group. Both groups received TENS therapy and hot packs, additionally, the study group received the Denneroll cervical traction orthotic. Interventions were applied at a frequency of 3 x per week for 10 weeks and groups were followed for an additional 6-months. Radiographic measures included cervical lordosis (CL) from C2–C7 and FHP; postural measurements included: lumbar lordosis, thoracic kyphosis, trunk inclination, lateral deviation, trunk imbalance, surface rotation, and pelvic inclination. Leg and back pain scores, Oswestry Disability Index (ODI), and H-reflex latency and amplitude were measured. Statistically significant differences between the groups at 10 weeks were found: for all postural measures, CL (p = 0.001), AHT (p = 0.002), H-reflex amplitude (p = 0.007) and latency (p = 0.001). No significant difference for back pain (p = 0.2), leg pain (p = 0.1) and ODI (p = 0.6) at 10 weeks were identified. Only the study group’s improvements were maintained at the 6-month follow up while the control groups values regressed back to baseline. At the 6-month follow-up, it was identified in the study group that improved cervical lordosis and reduction of FHP were found to have a positive impact on 3D posture parameters, leg and back pain scores, ODI, and H-reflex latency and amplitude.
Prevalence and Management of Incidental Testicular Masses—A Systematic Review
Authors: Henriques Daniel , Mota Pinto Anabela , Donato Helena , Leão Ricardo
Published: September 2022

Management of incidentally diagnosed small testicular masses (STM) is controversial. Although there is the risk of malignancy, it might be realistic to safely seek preservation of testicles bearing benign masses. This study aims to systematically evaluate the evidence regarding prevalence of STMs, their benign or malignant histology and their management. We conducted a systematic literature search for studies reporting small or incidental testicular masses and their management by radical orchiectomy, testis sparing surgery (TSS) or ultrasound (US) surveillance. We initially screened 2126 abstracts and from these, 57 studies met the inclusion criteria. Testicular masses were detected in 1.74% of patients undergoing US examination. Regarding STMs removed by surgery, 41.12% were benign. Intraoperative frozen section examination (FSE) is a reliable tool to discriminate between benign and malignant testicular masses (average 93.05% accuracy), supporting TSS. Benign lesions were associated with smaller diameter (<1 cm 68.78% benign), were often hypoechoic and exhibited regular margins on US. Conclusions: Small testicular masses are often benign. Clinical and US patterns are not accurate enough for including patients in surveillance protocols and TSS paired with FSE is pivotal for precluding the removal of testicles bearing benign lesions. Future research might unveil new imaging tools or biomarkers to support clinical management.
Sarcopenia Is an Independent Risk Factor for Subsequent Osteoporotic Vertebral Fractures Following Percutaneous Cement Augmentation in Elderly Patients
Authors: Lidar Shira , Salame Khalil , Chua Michelle , Khashan Morsi , Ofir Dror , Grundstein Alon , Hochberg Uri , Lidar Zvi , Regev Gilad J.
Published: September 2022

Introduction: Subsequent osteoporotic vertebral fractures (SOVF) are a serious complication of osteoporosis that can lead to spinal deformity, chronic pain and disability. Several risk factors have been previously identified for developing SOVF. However, there are conflicting reports regarding the association between sarcopenia and multiple vertebral compression fractures. As such, the goal of this study was to investigate whether sarcopenia is an independent risk factor of SOVF. Methods: This was a retrospective case–control study of elderly patients who underwent percutaneous vertebral augmentation (PVA) due to a new osteoporotic vertebral compression fracture (OVCF). Collected data included: age, sex, BMI, steroid treatment, fracture level and type, presence of kyphosis at the level of the fracture and bone mineral density (BMD). Identification of SVOFs was based on clinical notes and imaging corroborating the presence of a new fracture. Sarcopenia was measured using the normalized psoas muscle total cross-sectional area (nCSA) at the L4 level. Results: Eighty-nine patients that underwent PVA were followed for a minimum of 24 months. Average age was 80.2 ± 7.1 years; 58 were female (65.2%) and 31 male (34.8%). Psoas muscle nCSA was significantly associated with age (p = 0.031) but not with gender (p = 0.129), corticosteroid treatment (p = 0.349), local kyphosis (p = 0.715), or BMD (p = 0.724). Sarcopenia was significantly associated with SOVF (p = 0.039) after controlling for age and gender. Conclusions: Psoas muscle nCSA can be used as a standalone diagnostic tool of sarcopenia in patients undergoing PVA. In patients undergoing PVA for OVCF, sarcopenia is an independent risk factor for SOVF.
The Role of Iron in Calciphylaxis—A Current Review
Authors: Wickens Olivia , Rengarajan Sharmilee , Chinnadurai Rajkumar , Ford Ian , Macdougall Iain C. , Kalra Philip A. , Sinha Smeeta
Published: September 2022

Calcific uraemic arteriolopathy (CUA), also known as calciphylaxis, is a rare and often fatal condition, frequently diagnosed in end-stage renal disease (ESRD) patients. Although exact pathogenesis remains unclear, iron supplementation is suggested as a potential risk factor. Iron and erythropoietin are the main stay of treatment for anaemia in ESRD patients. Few observational studies support the role of iron in the pathogenesis of calciphylaxis although data from the pivotal trial was not strongly supportive of this argument, i.e., no difference in incidence of calciphylaxis between the low-dose and high-dose iron treatment arms. Elevated levels of vascular cell adhesion molecules in association with iron excess were postulated to the pathogenesis of CUA by causing inflammation and calcification within the microvasculature. In-addition, oxidative stress generated because of iron deposition in cases of systemic inflammation, such as those seen in ESRD, may play a role in vascular calcification. Despite these arguments, a direct correlation between cumulative iron exposure with CUA incidence is not clearly demonstrated in the literature. Consequently, we do not have evidence to recommend iron reduction or cessation in ESRD patients that develop CUA.
Is It Possible to Diagnose Preoperatively a Tubal Ectopic Hydatidiform Molar Pregnancy? Description of a Case Report and Review of the Literature of the Last Ten Years
Authors: D’Asta Marco , La Ferrera Nicolò , Gulino Ferdinando Antonio , Ettore Carla , Ettore Giuseppe
Published: September 2022

Synopsis: Nowadays there are no clinical, laboratory, or ultrasound criteria to differentiate ectopic tubal pregnancy from tubal molar pregnancy, so a preoperative diagnosis is not possible. Objective: Tubal ectopic hydatidiform moles are a rare type of gestational trophoblastic disease. The aim of our work is to understand if it is possible to diagnose, preoperatively, a tubal ectopic molar pregnancy, starting from the evaluation of a complicated case report up to performing a review of the literature. Materials and Methods: A 27-year-old woman was referred to our department for right pelvic pain, vaginal bleeding, and positive beta-hCG (590 mUI/mL). At the ultrasound, the uterine cavity was empty and a unilocular cyst of 15 mm below the right ovary, suspicious of ectopic pregnancy, was described. Serial measurements of daily beta-hCG (2031 → 2573 → 3480 mUI/mL) and, after five days, a laparoscopic salpingectomy, were performed. The pathologist confirmed a diagnosis of “incomplete invasive vesicular mole with extrauterine implant”. A review of the literature was performed, following the PRISMA statement, and searching all the articles related to this topic in the last ten years from PUBMED. We obtained data from thirteen studies, describing fourteen cases. Discussion: Considering the data from the literature, the main clinical symptoms were pelvic pain (100%), vaginal bleeding (64%), vomiting (7%), and fever (7%). By ultrasound examination, left adnexal mass on ten women (72%), and right adnexal mass on four (28%), were described. An assessment of ectopic pregnancy was made in all cases, but no preoperative diagnosis of tubal molar pregnancy was made. Beta-hCG levels were the same as patients with ectopic tubal pregnancy. Conclusion: Nowadays there are no clinical, laboratory, or ultrasound criteria to differentiate ectopic tubal pregnancy from tubal molar pregnancy.
RETRACTED: Is Increasing Age Associated with Higher Rates of Intercostal Arteries Vulnerable to Laceration? A Point of Care Ultrasound Study
Authors: Salame Gerard , Wittrock Elizabeth , Patel Hardik , Hafen Brant , Levi Ayal , Millard Tyler
Published: September 2022

Ultrasound-guided pre-procedural planning decreases complications from bedside thoracentesis. Although rare, intercostal artery (ICA) laceration is a serious complication that occurs when vulnerable intercostal arteries (VICA) are no longer protected by the superior rib. We sought to determine if increasing patient age is associated with greater odds of encountering a VICA. Randomly selected in-patients underwent pre-procedural planning for a mock posterior bedside thoracentesis. ICAs were categorized as vulnerable if they were visible within the corresponding intercostal space (ICS). We recorded where the VICA entered and exited the ICS as well as its unshielded length. A total of 40 patients (20 male) were enrolled and 240 ICS (6 ICS per patient) were scanned. Within this cohort, 25% of patients were noted to have at least one VICA. We could not demonstrate any relationship between the patient’s age or location of the ICS, with the odds of encountering a VICA (odds ratio (OR) = 1.0, p = 0.76; OR = 0.85, p = 0.27, respectively). Given the haphazard nature of VICA distribution and poor outcomes associated with inadvertent laceration, we recommend that ICA screening at the site of needle insertion be routinely performed prior to thoracentesis.
Placental Volume and Uterine Artery Doppler in Pregnancy Following In Vitro Fertilization: A Comprehensive Literature Review
Authors: Resta Serena , Scandella Gaia , Mappa Ilenia , Pietrolucci Maria Elena , Maqina Pavjola , Rizzo Giuseppe
Published: September 2022

The number of pregnancies achieved using in vitro fertilization (IVF) is rapidly increasing around the world. The chance of obtaining a successful pregnancy is also significantly improved due to technological advances and improvement in infertility treatment. Despite this success, there is evidence that pregnancy conceived by IVF has an increased risk of adverse maternal and perinatal outcome mainly represented by the development of hypertensive diseases, pre-eclampsia, and fetal growth restriction. Although different cofactors may play a role in the genesis of these diseases, the development of the placenta has a pivotal function in determining pregnancy outcomes. Advances in ultrasound technology already allows for evaluation in the first trimester, the impedance to flow in the uterine artery, and the placental volume using Doppler and three-dimensional techniques. This review article aims to describe the modification occurring in placental volume and hemodynamics after IVF and to summarize the differences present according to the type of IVF (fresh vs. frozen-thawed embryos).
Shedding of the Endothelial Glycocalyx Independent of Systemic Tryptase Release during Oncologic Oral Surgery: An Observational Study
Authors: Drinhaus Hendrik , Schroeder Daniel C. , Hunzelmann Nicolas , Herff Holger , Annecke Thorsten , Böttiger Bernd W. , Wetsch Wolfgang A.
Published: September 2022

The endothelial glycocalyx and endothelial surface layer are crucial for several functions of the vasculature. Damage to the glycocalyx (“shedding”) occurs during diverse clinical conditions, including major surgery. Mast cell tryptase has been proposed as one possible “sheddase”. During oncologic oral surgery, glycocalyx shedding could be detrimental due to loss of vascular barrier function and consequent oedema in the musculocutaneous flap graft. Concentrations of the glycocalyx components heparan sulphate and syndecan-1, as well as of tryptase in blood serum before and after surgery, were measured in 16 patients undergoing oncologic oral surgery. Secondary measures were the concentrations of these substances on postoperative days 1 and 2. Heparan sulphate rose from 692 (median, interquartile range: 535–845) to 810 (638–963) ng/mL during surgery. Syndecan-1 increased from 35 (22–77) ng/mL to 138 (71–192) ng/mL. Tryptase remained virtually unchanged with 4.2 (3–5.6) before and 4.2 (2.5–5.5) ng/mL after surgery. Concentrations of heparan sulphate and syndecan-1 in serum increased during surgery, indicating glycocalyx shedding. Tryptase concentration remained equal, suggesting other sheddases than systemic tryptase release to be responsible for damage to the glycocalyx. Investigating strategies to protect the glycocalyx during oncologic oral surgery might hold potential to improve flap viability and patient outcome.
Inflammatory Surrogate Parameters for Predicting Ifosfamide-Induced Neurotoxicity in Sarcoma Patients
Authors: Schmidt Moritz , Benzler Katrin , Lauer Ulrich M. , Zender Lars , Hinterleitner Clemens , Hinterleitner Martina
Published: September 2022

Sarcomas compromise a heterogenous group of tumors of a mesenchymal origin. Although treatment options in many solid tumors have evolved over the past decades, the treatment of advanced sarcoma is still based on conventional chemotherapeutic agents. Beside anthracyclines, alkylating agents such as ifosfamide are frequently used in sarcoma treatment. However, treatment with ifosfamide can cause severe dose- and treatment-limiting side effects, such as ifosfamide-induced neurotoxicity (IIN). Especially in sarcoma, consecutive risk assessment analyses investigating the individual factors associated with the increased incidence in IIN, remain insufficient so far. In this retrospective analysis, we investigated 172 sarcoma patients treated with ifosfamide. Out of 172 patients, 49 patients (28.5%) developed IIN. While gender, age, histologic origin, and tumor stage were not associated with the occurrence of IIN, infusion times, simultaneous radiotherapy, and concomitant use of opioids or anticonvulsants affected the risk of developing IIN. Sarcoma patients with IIN showed an alteration in several inflammatory markers, including a lower lymphocyte count, hemoglobin levels, and calcium levels, as well as elevated GGT, sodium, and CRP levels. Remarkably, the occurrence of IIN was associated with a worse prognosis regarding progression free and overall survival. In addition, high CTCAE grades were negatively associated with overall survival in sarcoma. The observation that an inflammatory state is associated with an increased risk of IIN in sarcoma patients can be used prospectively to further investigate the relationship of inflammation and IIN. In addition, the easily accessible blood markers used in our study to predict IIN can be incorporated into clinical decision making.
High-Performance Liquid Chromatography for Ultra-Simple Determination of Plasma Voriconazole Concentration
Authors: Yasu Takeo , Nomura Yuka , Gando Yoshito , Matsumoto Yasuhiko , Sugita Takashi , Kosugi Nobuharu , Kobayashi Masayuki
Published: September 2022

Voriconazole is an antifungal drug used to treat invasive aspergillosis. Voriconazole exhibits nonlinear behavior and considerable individual variability in its pharmacokinetic profile. Invasive aspergillosis has a poor prognosis, and failure of treatment owing to low voriconazole blood levels is undesirable. Thus, therapeutic drug monitoring (TDM) of voriconazole is recommended. However, plasma voriconazole concentration is rarely measured in hospitals, and the TDM of voriconazole is not widely practiced in Japan. We aimed to develop an ultra-simple method to measure plasma voriconazole concentration. Ten microliters of plasma sample was extracted, and proteins were precipitated using methanol extraction. Voriconazole and ketoconazole (internal standard) were separated using high-performance liquid chromatography. A calibration curve was prepared, which was linear over plasma voriconazole concentrations of 0.125–12.5 µg/mL, with a coefficient of determination of 0.9999. The intra-day and inter-day validation coefficients were 0.9–2.2% and 1.3–6.1%, respectively. The assay accuracy was −4.2% to 1.6%, and recovery was >97.8%. Our ultra-simple, sensitive, and inexpensive high-performance liquid chromatography ultraviolet method to determine plasma voriconazole concentration will help improve the voriconazole TDM implementation rate and contribute to effective and safe voriconazole use.
Impact of Genetic Polymorphisms and Biomarkers on the Effectiveness and Toxicity of Treatment of Chronic Myeloid Leukemia and Acute Myeloid Leukemia
Authors: Alarcón-Payer Carolina , Sánchez Suárez María Del Mar , Martín Roldán Alicia , Puerta Puerta José Manuel , Jiménez Morales Alberto
Published: September 2022

Most malignant hematological diseases are generally a consequence of acquired mutations or rearrangements in cell replication processes. Acute myeloid leukemia (AML) is a clinically and molecularly heterogeneous disease that results from acquired genetic and epigenetic alterations in hematopoietic progenitor cells. Despite the advances made in understanding the pathogenesis of this disease, the overall survival of patients remains very low due to the high relapse rate. Pharmacogenetics and massive sequencing studies have allowed the identification of new recurrent mutations with significant prognostic impact in AML; furthermore, it seems likely that whole genome sequencing will soon become a standard diagnostic test, which will allow the molecular diagnosis of patients. Therefore, it is necessary to develop molecular targets that open new therapeutic perspectives and allow individualized treatment of patients with this aggressive disease. Chronic myeloid leukemia (CML) is the first neoplastic disease for which a characteristic genetic alteration was described. It has, by definition, a genetic marker, the BCR::ABL1 rearrangement, as a consequence of the t9;22(q34;q11) translocation. Its study is essential for the diagnosis of this entity and also for monitoring the response to treatment. Drugs known as tyrosine kinase inhibitors (TKIs) that target the BCR::ABL1 protein (oral targeted therapy) are the conventional treatment of CML, representing a change of paradigm in the management of oncohematological patients.
Sustainable versus Conventional Cryptocurrencies in the Face of Cryptocurrency Uncertainty Indices: An Analysis across Time and Scales
Authors: Haq Inzamam UI , Bouri Elie
Published: September 2022

Are conventional and sustainable cryptocurrencies effective hedging instruments for high cryptocurrency uncertainty? This paper examines co-movements between conventional (Bitcoin, Ethereum, Binance Coin, Tether) and sustainable (Cardano, Powerledger, Stellar, Ripple) cryptocurrencies and two cryptocurrency uncertainty indices (UCRY price and UCRY policy). Using weekly returns from 1 October 2017 to 30 March 2021, the paper employs the bivariate wavelet coherence method considering three investment horizons, short-term, medium-term, and long-term. The results confirm that conventional and sustainable cryptocurrencies show consistent positive and identical co-movements with both cryptocurrency uncertainty indices at the short-term horizon during COVID-19 and negative co-movement at the medium-term investment horizon, suggesting the short-term hedging ability of dirty/green cryptocurrencies for high UCRY price and policy. Evidence of negative coherences shows that higher cryptocurrency prices and policy uncertainties lead to lower cryptocurrency returns, reflecting the adverse impact of higher uncertainties on the trust of crypto traders and investors. Weak co-movement is found between dirty/green cryptocurrencies and UCRY price/policy indices, which suggests the possible role of dirty/green cryptocurrencies as a weak hedge for UCRY price and policy indices. These findings provide potential avenues to hedge cryptocurrency uncertainties using conventional and sustainable cryptocurrencies across multiple investment horizons.
Theoretical Study on the Dynamic Characteristics of Marine Stern Bearing Considering Cavitation and Bending Deformation Effects of the Shaft
Authors: He Tao , Xie Zhongliang , Ke Zhiwu , Dai Lu , Liu Yong , Ma Can , Jiao Jian
Published: September 2022

When the ship runs, owing to the superposition of the gravity of the shaft and resistance of water, with the increment in rotational speeds, the shaft will produce different degrees of bending deformation, which immensely reduces the power transmission efficiency. Based on the aforementioned problem, the present study focuses on the influences of bending deformation of the shaft with a cavitation effect on the dynamic characteristics of the stern bearing. The mixed lubrication model with bending deformation and cavitation effect is established. At present, the deflection curve equation is employed, the finite perturbation method is applied to calculate the dynamic coefficient, and the cavitation pressure is determined by the numerical method. According to the analysis, the variation laws of equivalent stiffness and natural frequency are exhibited. It is shown that the equivalent stiffness is more affected by the speeds, especially at low speeds; There is a critical speed between 130 rpm and 150 rpm, which makes the natural frequency strike the maximum value. Finally, the research results provide a theoretical basis for the ships to avoid large vibration during navigation.
Optimization of Air Conditioning Performance with Al2O3-SiO2/PAG Composite Nanolubricants Using the Response Surface Method
Authors: Zawawi Nurul Nadia Mohd , Azmi Wan Hamzah , Redhwan Abd Aziz Mohamad , Ramadhan Anwar Ilmar , Ali Hafiz Muhammad
Published: September 2022

A variety of operational parameters can influence the operation of an automobile air-conditioning (AAC) system. This issue is solved by using optimization techniques that can recommend the ideal parameters for the best results. To improve the performance of AAC system usings Al2O3-SiO2/PAG composite nanolubricants, the response surface method (RSM) was employed. RSM was used to design the experimental work, which was based on a face composite design (FCD). The RSM quadratic models were helpful in determining the links between the input parameters and the responses. The addition of composite nanolubricants improved the overall performance of AAC systems. The parameters were optimized using the RSM’s desirability approach, with the goal of increasing cooling capacity and the coefficient of performance (COP), while reducing compressor work and power consumption. The ideal parameters for the AAC system were found to be 900 rpm compressor speed, 155 g refrigerant charge, and 0.019% volume concentration, with a high desirability of 81.60%. Test runs based on the optimum circumstances level were used to estimate and validate cooling capacity, compressor work, COP, and power consumption. Both predicted and measured values were in good agreement with each other. A new RSM model was successfully developed to predict the optimal conditions for AAC system performance.