bluuebunny/crossref_metadata_2025 huggingface dataset:
Carboxylate catalyzed isomerization of β,γ-unsaturated NAC thioesters
Authors: Riuttamäki Saara , Laczko Gergely , Madarasz Adam , Földes Tamas , Papai Imre , Bannykh Anton , Pihko Petri
Published: April 2022

We demonstrate herein the capacity of simple carboxylate salts – tetrametylammo-nium and tetramethylguanidinium pivalate – to act as catalysts in the isomerization of β,γ-unsaturated thioesters to α,β-unsaturated thioesters. The carboxylate catalysts gave reaction rates comparable to those obtained with DBU, but with fewer side reactions. The reaction exhibits a normal secondary kinetic isotope effect (k1H/k1D = 1.065±0.026) with a β,γ-deuterated substrate. Computational analysis of the mechanism provides a similar value (k1H/k1D = 1.05) with a mechanism where -reprotonation of the enolate intermediate is rate determining.We demonstrate herein the capacity of simple carboxylate salts – tetrametylammo-nium and tetramethylguanidinium pivalate – to act as catalysts in the isomerization of β,γ-unsaturated thioesters to α,β-unsaturated thioesters. The carboxylate catalysts gave reaction rates comparable to those obtained with DBU, but with fewer side reactions. The reaction exhibits a normal secondary kinetic isotope effect (k1H/k1D = 1.065±0.026) with a deuterated substrate. Computational analysis of the mechanism provides a similar value (k1H/k1D = 1.05) with a mechanism where γ-reprotonation of the enolate intermediate is rate determining.
How Robust are Modern Graph Neural Network Potentials in Long and Hot Molecular Dynamics Simulations?
Authors: Stocker Sina , Gasteiger Johannes , Becker Florian , Günnemann Stephan , Margraf Johannes T.
Published: April 2022

Graph neural networks (GNNs) have emerged as a powerful machine learning approach for the prediction of molecular properties. In particular, recently proposed advanced GNN models promise quantum chemical accuracy at a fraction of the computational cost. While the capabilities of such advanced GNNs have been extensively demonstrated on benchmark datasets, there have been few applications in real atomistic simulations. Here, we therefore put the robustness of GNN interatomic potentials to the test, using the recently proposed GemNet architecture as a testbed. Models are trained on the QM7-x database of organic molecules and used to perform extensive MD simulations. We find that low test set errors are not sufficient for obtaining stable dynamics and that severe pathologies sometimes only become apparent after hundreds of ps of dynamics. Nonetheless, highly stable and transferable GemNet potentials can be obtained with sufficiently large training sets.
Benzylic fluorination induced by N–F bond activation of Selectfluor® with a solvent-dependent selectivity switch
Authors: Madani Amiera , Anghileri Lucia , Heydenreich Matthias , Möller Heiko M. , Pieber Bartholomäus
Published: April 2022

We present a divergent radical strategy for the fluorination of phenylacetic acid derivatives through N–F bond activation of Selectfluor® with 4-(dimethylamino)pyridine. Comprehensive reaction investigation revealed the critical role of reaction media on selectivity. In presence of water, decarboxylative fluorination through a single electron oxidation is dominant. Non-aqueous conditions result in the clean formation of α-fluoro-α-arylcarboxylic acids through hydrogen atom transfer.
An Approach to High Throughput Measurement of Accurate Retention Data in Liquid Chromatography
Authors: Stoll Dwight , Kainz Gudrun , Dahlseid Tina , Kempen Trevor , Brau Tyler , Pirok Bob
Published: April 2022

Efforts to model and simulate various aspects of liquid chromatography (LC) separations (e.g., retention, selectivity, peak capacity, injection breakthrough) depend on experimental retention measurements to use as the basis for the models and simulations. Often these modeling and simulation efforts are limited by datasets that are too small because of the cost (time and money) associated with making the measurements. Other groups have demonstrated improvements in throughput of LC separations by focusing on “overhead” associated with the instrument itself – for example, between-analysis software processing time, and autosampler motions. In this paper we explore the possibility of using columns with small volumes (i.e., 5 mm x 2.1 mm i.d.) compared to conventional columns (e.g., 100 mm x 2.1 mm i.d.) that are typically used for retention measurements. We find that isocratic retention factors calculated for columns with these dimensions are different by about 20%; we attribute this difference – which we interpret as an error in measurements based on data from the 5 mm column – to extra-column volume associated with inlet and outlet frits. Since retention factor is a thermodynamic property of the mobile/stationary phase system under study, it should be independent of the dimensions of the column that is used for the measurement. We propose using ratios of retention factors (i.e., selectivities) to translate retention measurements between columns of different dimensions, so that measurements made using small columns can be used to make predictions for separations that involve conventional columns. We find that this approach reduces the difference in retention factors (5 mm compared to 100 mm columns) from an average of 18% to an average of less than 1%. This approach will significantly increase the rate at which high quality retention data can be collected to thousands of measurements per instrument per day, which in turn will likely have a profound impact on the quality of models and simulations that can be developed for many aspects of LC separations.
Pd-Catalyzed 1,4-Carboamination of Bromoarenes with Diazo Compounds and Amines
Authors: Wu Qikun , Muto Kei , Yamaguchi Junichiro
Published: April 2022

A palladium-catalyzed 1,4-carboamination of bromoarenes with diazo compounds and amines was developed. This reaction proceeds through a palladium-carbene that then generates a π-benzylpalladium intermediate, forming ipso C–C and para C–N bonds on haloarenes in a regioselective manner. The nature of this reaction as a multi-component reaction and its high regioselectivity can lead to a rapid construction of a range of para-substituted anilines. The successful application of this transformation to the rapid synthesis of an anti-tumor agent demonstrates its synthetic utility.
Milliwatt Three- and Four-Pulse Double Electron Electron Resonance for Protein Structure Determination.
Authors: Teucher Markus , Sidabras Jason , Schnegg Alexander
Published: April 2022

Electron paramagnetic resonance (EPR) experiments for protein structure determination using double electron-electron resonance (DEER) spectroscopy rely on very high incident microwave powers (>300 W) to create the short pulse lengths needed to excite a sizable portion of the spectrum. The recently introduced self-resonant microhelix combines a high B1 conversion efficiency with an intrinsically large bandwidth (low Q-value) and a high absolute sensitivity. We report dead times as low as 14±2 ns achieved using less than 1 W of power at X-band (nominally 9.5 GHz) on a molecular ruler and a T4-lysozyme sample. These low-power experiments were performed using an active volume 120 times smaller than that of a standard pulse EPR resonator, while only a sixfold decrease in the signal-to-noise ratio was observed. Small build sizes, as realized with the microhelix, give access to volume-limited samples, while shorter dead times allow the investigation of fast relaxing spin species. With the significantly reduced dead times, the 3-pulse DEER experiment can be revisited. Here, we show experimentally that 3-pulse DEER offers superior sensitivity over the 4-pulse DEER. We assert that the microhelix paves the road for low-cost benchtop X-band pulse EPR spectrometers by eliminating the need for high-power amplifiers, accelerating the adoption of pulse EPR to a broader community.
Reliability and Differences Between Sexes in Landing Mechanics when Performing the Lateral Bound Test
Authors: Waldhelm Andy , Allen Sydney , Grand Lacy , Bopp Carolyn , Foster Kristian , Muckridge Ginger , Schwarz Neil
Published: April 2022

Background and Purpose

Anterior cruciate ligament injuries are prevalent among the athletic population, imposing a heavy economic burden, and the risk of re-injury. Most current biomechanical screening tasks are performed in the sagittal plane, and there is a need for more screening tools that assess sports specific movements in the frontal plane. The purpose of this study was to determine the reliability of and examine differences between sexes in the performance of the Lateral Bound Test (LBT).

Materials/Methods

Each subject performed three trials of a LBT which included jumping laterally from one leg over a hurdle and landing on the opposite leg. Two cameras were placed six feet from the landing marker. Maximum dynamic knee valgus using the frontal plane projection angle and knee flexion angle at initial contact and maximal knee flexion were measured upon landing leg using 2D video analysis software. Additionally, video of 10 individuals’ trials were analyzed twice with one week between the analyses to obtain intra-rater reliability while 12 participants were retested one week later to determine test-retest reliability.

Results

Thirty healthy subjects, 16 males, 14 females participated. Intra-rater reliability was determined to be excellent for all variables (ICC>0.96). In contrast, the test-retest reliability had greater disparity. Test-retest reliability ranged from poor (ICC = 0.47) to excellent (ICC > 0.90). Significant differences existed between the sexes, including males being significantly taller, weighing more, and demonstrating greater bilateral dynamic knee valgus (p < 0.05). No significant differences existed between sexes for knee flexion angles.

Conclusion

The new LBT had excellent intra-rater reliability for assessing dynamic knee valgus and initial and maximum knee flexion angle when performing a functional movement in the frontal plane. Furthermore, males landed with more dynamic knee valgus than females which is contradictory to what has been observed with functional screening tools performed in the sagittal plane.

Level of Evidence

3b (reliability study)
Review of Primary Level Curriculum for Students having Vision Related Challenges Formulated by Punjab Textbook Board, Lahore
Authors: Jahanzaib Muhammad , Fatima Ghulam , Nayab Dur e
Published: April 2022

Purpose: Although Single National Curriculum (SNC) is implemented in all over the country from April 2021 at primary level as per commitment of the ruling party in Pakistan. However, the pre-existing and implemented curriculum formulated by Punjab Curriculum and Textbook Board is still followed in special education institutions of Punjab because preparation process is still going on for the implementation of SNC in these institutions.  The academic capability of Children with Visual Impairment (CWVI) is usually considered as that of non-disabled students due to their good cognitive skills. Directorate of Special Education Punjab adopted the same curriculum for CWVI. This study is an effort to identify the standards, benchmarks and student learning outcomes (SLOs) which are difficult to accomplish for CWVI.

Methodology: It was a descriptive qualitative study by nature and curriculum review/document analysis technique was applied to study the implemented and existing curriculum. The complete curriculum of six key learning areas at pre-primary level proposed by implemented curriculum are as follows; personal and civic sense, language related learning, nature numerical  concepts, our environment and surroundings, personal care, personal cleanliness and self protection, and artistic abilities. likewise existing curriculum offers these learning areas till fifth grade; Islamiat/ Ethics and morality, Urdu, English, Maths, Science, General Knowledge and Social Studies. The data were retrieved from the website of Punjab Curriculum and Textbook Board. Obtained data was coded; basic themes were extracted & discussed.

Findings: study demonstrated that many standards, benchmarks and student learning outcomes (SLOs) were attainable for students with visual challenges like regular students however several standards, benchmarks and student learning outcomes were found problematic for children having vision related disabilities because of their handicapping condition and unavailability of assistive technology in their educational institutions.

Implications: Need based amendments maybe applied for visually challenged students particularly for the achievement of standards, benchmarks and students learning outcomes in geography, geometry, and sciences. Pictures, sketches and maps should be replaced by other productive activities for blind and low vision students.
CITRA PENARI TOPENG BANJET GRUP SINAR PUSAKA WARNA KARAWANG
Authors: Sadono Soni , Pebrianti2 Paramitha , Maulana Teddy Ageng
Published: April 2022

Penelitian ini bertujuan untuk mengetahui citra,  gambaran, dan kesan penari dalam kelompok seni Topeng Banjet. Penelitian ini dilakukan dengan berfokus pada kelompok seni Sinar Pusaka Warna Kabupaten Karawang pimpinan Bah Pendul yang merupakan kelompok Topeng Banjet tertua di Karawang. Melalui pemaparan data secara deskriptif  dan analitik, dalam penelitian ini peneliti menggunakan pendekatan kualitatif. Dengan memberikan gambaran masyarakat di Kabupaten Karawang, maka dapat diketahui bahwa kesan-kesan erotis yang disuguhkan oleh penari pada pertunjukan Topeng Banjet dipengaruhi oleh latar belakang pola hidup masyarakat Karawang. Sampai lahirkah sebuah istilah Goyang Karawang yang menjadi sebutan untuk perantau dari Karawang sebagai identitas orang dari Karawang. Minatnya masyarakat terhadap tarian tersebut kemudian melahirkan penari dan kelompok-kelompok seni di Karawang. Kata kunci : Penari Topeng Banjet, Bah Pendul, Goyang Karawang
A Traditional Game-Based Parenting Model as a Cultural-Inheritance Medium in Early Childhood Education
Authors: Suteja Suteja , Saifuddin Saifuddin , Farihin Farihin , Aris Aris , Winarso Widodo
Published: April 2022

Education related to parenting must be provided for parents to have a broad perspective in preparing a child's education. The use of traditional games in parenting can be developed to apply and preserve the local values and norms in the next generation from an early age. Based on traditional games, a parenting model is also an effort to transmit good and wise local culture to pre-school children. This research offers a parenting model based on the traditional games relevant to pre-school child education (PAUD – Pendidikan Anak Usia Dini). This type of research comprises Research and Development, which references ADDIE (Analysis, Design, Development, Implementation, and Evaluation). After the parenting model has been designed, this model subsequently goes through a validation phase with parenting-model subject-matter experts and design experts, in order to elicit suggestions for improvement until this model can be stated as suitable to be categorized as 'good'. After the validation and revision phases, the researchers conducted a trial, in order to understand student perceptions when using the model. A parenting model based on traditional games can be expected to instil an awareness of the importance of local culture, and as an effort to make best use of a child’s formative years, which is seldom done. Parenting, based on traditional games, is of no less interest than other parenting models. The parenting model developed in this research contributes to the development of teaching material for pre-school children's education.
OPTIMALISASI PERAN PENDAMPING DALAM PROSES PENGEMBANGAN DIRI PENYANDANG TUNANETRA DI PANTI PELAYANAN SOSIAL DISABILITAS SENSORIK NETRA PENDOWO KUDUS
Authors: Nafi Ahmad
Published: April 2022

ABSTRAKSeiring perkembangan zaman pandangan sebagaian besar masyarakat terhadap anak berkebutuhan khusus (ABK) khususnya tuna netra, masih banyak yang terabaikan bahkan terkucilkan. Kondisi tersebut tentunya membawa dampak langsung maupun tidak langsung terhadap tumbuh kembang ABK, bahkan terhadap keluarganya. Penelitian ini bertujuan untuk melihat keterlibatan pekerja sosial atau pendamping terkait proses kegiatan pengembangan diri yang dilakukan di Panti Pelayanan Sosial Disabilitas Sensorik Netra Pendowo Mlati Kudus. Metode penelitian yang digunakan oleh penulis pada penelitian ini adalah deskriptif kualitatif,   karena fokus penelitiannya adalah bagaimana peran pendamping pada proses pengembangan diri penerima manfaat di Panti Pelayanan Sosial Disabilitas Sensorik Netra Pendowo Kudus tahun 2021. Melalui pendekatan kualitatif, peneliti dapat memahami fenomena tentang apa yang dialami oleh subyek penelitian misalnya perilaku, persepsi, motivasi, kebiasaan dan lainnya.
Pelestarian Kesenian Gondang Brogong Sebagai Upaya Menumbuhkan Kecintaan Budaya Lokal di Pasir Pengaraian
Authors: Pratama Nandho Pur , Irwan Irwan , Wilman Wilman
Published: April 2022

This study discusses the form and spirit of preserving the art of Gondang Brogong in Lenggopan Village, Pasir Pangaraian. The aim is to find out the views of the people of Lenggopan Village on the preservation of Gondang Brogong art and the contribution of this perspective to the preservation of Gondang Brogong. Through qualitative research, with the basis of tracing the oral history of Gondang Brogong art and several concepts regarding the preservation of local culture, the research is directed to find out how to preserve Gondang Brogong art. The results of the study prove that Gondang Brogong in Lenggopan Village is still sustainable today, because its presence in traditional ceremonies cannot be replaced by other arts. For the people of Lenggopan if an event does not feature Gondang Brogong, then the event is considered not festive and sacred.Keywords: preservation; traditional art; Gondang Brogong; Pasir PangaraianAbstrakPenelitian ini membahas tentang bentuk dan semangat pelestarian kesenian Gondang Brogong di Desa Lenggopan, Pasir Pangaraian. Tujuannya untuk mengetahui pandangan masyarakat Desa Lenggopan terhadap pelestarian kesenian Gondang Brogong dan sumbangan cara pandang tersebut atas kelestarian Gondang Brogong. Melalui penelitian kualitatif, dengan landasan penelusuran atas sejarah lisan kesenian Gondang Brogong dan beberapa konsep tentang pelestarian budaya lokal, penelitian diarahkan untuk mengetahui cara pelestarian kesenian Gondang Brogong. Hasil penelitian membuktikan bahwa Gondang Brogong di Desa Lenggopan masih tetap lestari sampai sekarang, karena kehadirannya dalam upacara adat tidak dapat digantikan oleh kesenian lain. Bagi masyarakat Lenggopan jika sebuah perhelatan tidak menampilkan Gondang Brogong, maka perhelatan tersebut dianggap tidak meriah dan sakral.Kata Kunci: pelestarian; kesenian tradisional; Gondang Brogong; Pasir Pangaraian
Cryptocurrency Risk Analysis During the Covid-19 Pandemic: Value at Risk (VaR) Approach
Authors: Khairunnisa Desy , Purwanto Budi , Ermawati Wita Juwita
Published: April 2022

The COVID-19 outbreak had a severe impact on almost all countries in the world. One aspect of concern during the pandemic is an investment. In this study, the GARCH model used to estimate Value at Risk (VaR) on cryptocurrency investments as a tolerable loss during the COVID-19 pandemic. Data in this study are ten cryptocurrencies with the largest capitalization. The observation period when WHO declared COVID-19 as a pandemic, namely on March 11, 2020 - June 11, 2020. From this study, the highest cryptocurrency VaR value is Crypto.com with an amount of 0,18214. It means that the maximum loss that an investor can tolerate with an investment of  $500.000.000 for a 95 percent confidence level is $ 91.070.392.
Analisis Beban Pencemar Logam Berat Industri terhadap Kualitas Sungai Citarum Hulu
Authors: Febrita Joana , Roosmini Dwina
Published: April 2022

Berbagai penelitian mengatakan bahwa kualitas Sungai Citarum sudah tidak memenuhi baku mutu. Sungai Citarum Hulu telah tercemar oleh logam berat. Hasil yang didapatkan belum menggambarkan pencemaran yang sebenarnya karena sebagian besar logam berat terakumulasi pada sedimen atau biota akuatik. Penelitian dilakukan dengan menganalisis konsentrasi logam berat di air dan sedimen sungai untuk mengetahui kualitas sungai kemudian melakukan simulasi pencemaran logam berat di air sungai bila efluen industri memenuhi baku mutu. Pengukuran logam berat dilakukan menggunakan AAS setelah mengekstraksi sampel air (SNI 6989.17:2009) dan sedimen (EPA Method 200.2 1994). Simulasi pencemaran logam berat di sungai dilakukan dengan menghitung konsentrasi campuran logam berat (air sungai dan efluen industri). Hasil pengukuran menunjukkan Sungai Citarum Hulu mengandung logam berat Cr, Cu, Zn, dan Ni baik pada air maupun sedimen sungai dari Danau Cisanti hingga Nanjung. Konsentrasi keempat logam berat pada sedimen lebih besar dari konsentrasi pada air. Pada air, konsentrasi logam terlarut lebih kecil dibandingkan dengan logam total. Lokasi dengan konsentrasi logam berat tertinggi pada air adalah Sapan dan Cisirung. Hasil simulasi menunjukkan bahwa walaupun industri mengeluarkan efluen sesuai dengan baku mutu efluen industri, baku mutu sungai pada beberapa daerah tetap tidak tercapai. Baku mutu sungai dan efluen serta sistem monitoring sungai perlu dievaluasi.
MODEL BISNIS TAMBAK UDANG VANAMIE EKSLUSIF
Authors: Adistya Diang , Agung Maulana , Wulandari Jeni
Published: April 2022

Lahan pesisir yang ada di Indonesia memiliki suatu potensi yang harus di kembangkan sehingga menjadi suatu bisnis yang berkelanjutan. Tambak udang memiliki potensi keuntungan yang tinggi karena di dukung data permintaan yang tinggi dengan jumlah pasokan terbatas. Lampung memiliki tambak udang eksklusif dengan kondisi yang sangat baik. Penelitian ini menggunakan metode deskriptif kualitatif. Hasil yang diperoleh adalah dengan model bisnis tambak udang ekslusif tingkat hidup udang sangat tinggi diatas 90 persen. Pola penambahan air kolam dapat dilakukan tanpa bak tamping dan waktu panen bisa mencapai 100 hari. Pengembangan model bisnis seperti ini sangat mengurangi resiko gagal panen akibat penyakit dari kolam lain yang berbeda kepengurusannya.
EFEKTIVITAS EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP INFEKSI JAMUR PADA TELUR IKAN GURAMI (Osphronemus gouramy)
Authors: Sumahiradewi Luh Gede , Sulystyaningsih Naning Dwi
Published: April 2022

Ikan gurami (Osphronemus gouramy) adalah jenis ikan air tawar asli perairan Indonesia yang sudah di kenal oleh hampir seluruh masyarakat Indonesia. Kegitan budidaya ikan gurami masih mengalami kendala dalam tahap penetasan telur diakibatkan serang jamur. Pemanfaatan daun pepaya sebagai bahan alami menjadi alternatif guna meningkatkan keberhasilan penetasan telur ikan gurami. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak daun papaya terhadap infeksi jamur pada telur ikan gurami serta dosisi yang optimal untuk meminimalisir infeksi jamur tersebut. Metode penelitian yang digunakan adalah metode eksperimental dengan Rancangan Acak Lengkap (RAL) yang terdiri dari empat perlakuan dan tiga kali ulangan. Perlakuan konsentrasi ekstrak daun pepaya yang diberikan meliputi P1 0 ppm (kontrol), P2 1000 ppm, P3 2000 ppm, dan P4 3000 ppm. Parameter uji yang diamati adalah prevalensi, daya tetas (HR) dan sintasan (SR) serta kualitas air. Hasil penelitian menunjukkan perendaman ekstrak daun pepaya memberikan pengaruh nyata terhadap prevalensi, daya tetas, dan sintasan pada telur ikan gurami dengan dosis terbaik 3000 ppm.
PENGARUH LINGKUNGAN BELAJAR DAN DISIPLIN BELAJAR TERHADAP HASIL BELAJAR PADA MATA PELAJARAN PRODUK KREATIF DAN KEWIRAUSAHAAN (PKK) SISWA SMKN 3 KOTA BLITAR
Authors: Hadi Sucipto Hadi Sucipto , M. Anas M. Anas , RR. Forijati RR. Forijati
Published: April 2022

The purpose of this study was to examine the effect of learning discipline and learning environment on learning outcomes of Creative Products and Entrepreneurship (PKK) students of SMKN 3 Blitar City in the odd semester of the 2018/2019 school year. This research uses descriptive analysis method, while inferential statistical analysis is multiple regression or change to find out the magnitude of the influence between the discipline of learning in school and the learning environment on learning outcomes. The conclusions of the results of this study are (1) The effect of the learning environment partially on the learning outcomes of the Creative Products and Entrepreneurship (PKK) students of SMKN 3 Blitar City in the odd semester of the 2018/2019 school year, (2) The effect of partial learning discipline on learning outcomes Creative and Entrepreneurship Product subjects (PKK) of SMKN 3 City Blitar students in the odd semester of the 2018/2019 school year, (3) The effect of simultaneous learning discipline and learning environment on learning outcomes of Creative and Entrepreneurship Product subjects (PKK) of SMKN 3 City students Blitar in the odd semester of the 2018/2019 school year
PENGARUH PEMBERIAN KOMPENSASI, MOTIVASI KERJA DAN TERHADAP PENINGKATAN PRESTASI KERJA KARYAWAN
Authors: Saleh Taufik Rahmad , Muninghar Muninghar , Riswati Fatimah
Published: April 2022

This research was conducted St Bank Jatim, Sumenep Branch, with a total sample of 57 people. The purpose of this study are: 1) To find out how the description of compensation assistance, work motivation, and work performance at Bank Jatim, Sumenep branch; 2) To support and analyze participation in the provision of compensation and work motivation on employee work performance at Bank Jatim, Sumenep branch; 3) To support and analyze compensation complaints, work motivation and organizational work simultaneously on the work performance of employees at Bank Jatim, Sumenep branch. Data analysis using SPSS, this type of research is explanatory research using quantitative research. The results showed that: 1) Compensation (X1) at Bank Jatim, Sumenep Branch can be expressed according to employee expectations, namely the existence of all kinds of rewards in the form of money such as salaries, various benefits, THR, incentives, commissions and others. Motivation (X2) of employees at Bank Jatim, Sumenep Branch, have had such a strong drive, desire or interest in them to achieve organizational goals. This system of shared meaning already has a number of key characteristics that the Sumenep Branch of the Bank Jatim organization is upholding; 2) Simultaneously, Compensation and Motivation have a significant influence on Employee Performance at Bank Jatim, Sumenep Branch.
ANALISIS PENGARUH MARKETING MIXTERHADAP CUSTOMER VALUE DI PELAYANAN RAWAT JALAN PUSKESMAS KEDUNGDORO
Authors: Slamet Imam Syafi’I  , Achmad Daeng GS  , Bambang Karnain
Published: April 2022

The number of patient visits at the Kedungdoro Health Center from 2019 to 2021 has decreased, both old and new patient visits. These conditions indicate that patient loyalty is low, the low patient loyalty can occur due to patient dissatisfaction which is influenced by the marketing mix. The purpose of this study was to determine the effect of the marketing mix, namely products, people, processes and physical evidence on customer value at the Kedungdoro Health Center.This study is a quantitative study with a cross-sectional study design. The study population was all patients in November as many as 1849 patients. The research sample was 178 patients and was taken by purposive sampling method. Data were collected by using a questionnaire instrument and analyzed by Multiple Linear Regression.The results of the research on hypothesis testing showed that the results of the t-test of the product, people, process and physical evidence variables partially had a significant positive effect on the customer value variable. In addition, the F test results show that all elements of the marketing mix (products, people, processes and physical evidence) simultaneously or simultaneously have a significant effect on customer value. Elements of the marketing mix that need to be evaluated in order to increase patient loyalty are people and physical evidence
Church and State and the Conflict over the Erosion of Morals in 18th-Century Russia
Authors: Kamenskii Alexander
Published: April 2022

At the beginning of the 18th century, sexual crimes, which until then were considered only a sin and were subject to ecclesiastical punishment, became crimes also subject to secular courts. Henceforth, the Orthodox Church and the state now had to interact in the fight against violations of the norms of people’s sexual behavior. The article analyzes how this interaction took place in practice and shows that there was a kind of competition between the Church and the state for power over emotions and bodies. At the same time, the state personified by secular officials appeared to be more sensitive to the changes taking place in Russian society and, in fact, was gradually ousting the Church from this sphere.
“Whomsoever He Wishes As His Successor”: Paul Bushkovitch on Succession and Absolutism in Early Modern Russia
Authors: Martin Russell E.
Published: April 2022

Paul Bushkovitch’s study of succession in Russia challenges a number of received historiographical traditions about succession and absolutism in early modern Russia. He questions the common view that power transferred from one ruler to the next by primogeniture and instead sees a long and largely uninterrupted tradition of parental designation. He also rejects the view that the concept of absolutism is useful for understanding monarchical power in Muscovy. Instead, Bushkovitch joins a growing group of historians who see the tsar ruling collaboratively with his boyars, making this a study as much about political culture as it is about succession. Some readers may find the conclusions about primogeniture to be highly revisionist and in need of further investigation, but the arguments about absolutism will no doubt influence in significant ways future works on power and politics, as historians continue to expand their understanding of pre-modern Russian political culture.
Virtud y vicio del obrero en la España del XIX (II): delincuencia y marginalidad
Authors: Casas Díaz Laura
Published: April 2022

Este nuevo estudio persigue exponer brevemente la correlación existente entre la delincuencia perpetrada por las clases trabajadoras y los escasos recursos económicos de los que éstas disponían en la España del siglo XIX. La hipótesis principal es que la imagen que tenía el legislador decimonónico acerca del criminal y la delincuencia originó una sobrerrepresentación dentro del sistema penal de las clases sociales provistas de un menor poder adquisitivo.
ÚLCERAS VENOSAS E AS MUDANÇAS PROVOCADAS NA ESTRUTURA FAMILIAR
Authors: Ascari Rosana Amora , Müller Gisiane Vitória , Carvalho Amanda Shaiane de , Weihermann Ana Maria Cisotto
Published: April 2022

Objetivo: Conhecer as mudanças provocadas na estrutura de famílias que têm um de seus membros com úlcera venosa (UV), residentes em um município catarinense. Metodologia: Trata-se de um estudo transversal, de abordagem qualitativa, desenvolvido com 12 participantes, por meio de entrevista semiestruturada, em setembro de 2021. Resultados: Os participantes tinham entre 35 e 78 anos, sendo sete homens e cinco mulheres, a maioria casado(a) ou com companheiro(a), residente em casa própria com seus familiares. Em relação às úlceras, oito tiveram início de forma traumática e quatro de forma espontânea, com duração de dois a trinta anos. Entre as mudanças ocorridas na vida dessas famílias, evidenciou-se grande dependência do portador da UV em relação ao seu familiar, responsável pelas mudanças no contexto da sua vida e a necessidade de auxílio financeiro. Considerações finais: As UV provocam mudanças na estrutura familiar, o que demanda uma visão ampliada dos profissionais de saúde para assistir o portador de UV e contemplar a atenção aos familiares.
PERCEPÇÃO DO CUIDADOR DIANTE DA LESÃO POR PRESSÃO DE PACIENTES ATENDIDOS NA ATENÇÃO DOMICILIAR
Authors: Dos Santos Débora Juliana , Oliveira Limeira Fabricia Nayara , Braz de Oliveira Alves Vittória
Published: April 2022

Objetivo: Identificar a percepção e sentimentos do cuidador familiar diante da lesão por pressão de pacientes atendidos no serviço de atenção domiciliar de um Centro Estadual de Reabilitação e Readaptação de Goiânia-GO. Método: Trata-se de um estudo de caráter descritivo, de cunho qualitativo, desenvolvido no período de julho a agosto de 2021. Os sujeitos da pesquisa foram 12 cuidadores familiares de pessoas com lesão por pressão, o projeto foi submetido ao Comitê de Ética do Centro Universitário de Brasília (UNICEUB), com parecer favorável de nº 4.713.743. Os critérios de inclusão foram: Pontuação mínima na aplicação do Mini exame de estado mental (MEEM), Cuidador familiar maior de 18 anos, sendo de ambos os sexos. Os critérios de exclusão: Como critério de descontinuação foi considerado a interrupção da pesquisa, por qualquer motivo, deficiência auditiva e dificuldade de comunicação. Para a coleta de dados foi utilizado nesse estudo a aplicação do Termo de Consentimento Livre Esclarecido, aplicação do MEEM e de um questionário com perguntas abertas e fechadas contendo dados sociodemográficos. Resultados: Os dados permitem identificar um grupo de participantes com idade em torno de 50 anos e, de suas falas, pode ser evidenciado cansaço e tristeza pela situação vivida. Apesar destes relatos, alguns participantes também discorreram acerca da utilização de recursos de enfrentamento, como a fé. Considerações Finais: Foi possível notar que os cuidadores têm conhecimento acerca da lesão por pressão e seus fatores de risco, porém, as consequências psíquicas são inerentes ao cuidado neste processo vivenciado.
Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries
Authors: Mukai Takeo , Sei Kenshi , Nagamura-Inoue Tokiko
Published: April 2022

Traumatic central nervous system (CNS) injury often causes irreversible impairment, and new alternative therapies for the treatment of CNS injury and sequelae are expected to be developed. Recently, mesenchymal stromal cells (MSCs) have started being used as cell therapy for neurological disorders such as traumatic CNS injury based on their immunomodulatory, neuroprotective, and neurorestorative abilities. Based on the premise of basic research, numerous clinical trials using MSCs for the treatment of traumatic CNS injury have been performed, and the feasibility and efficacy of this therapy have been reported. In this review we aimed to shed light on the characteristics of MSCs and to discuss the basic and clinical research and recent progress in clinical studies using MSCs to treat various traumatic neurological injuries.
What scans see when patients see defects: neuroimaging findings in body dysmorphic disorder
Authors: Machremi Elisavet , Bakirtzis Christos , Karakasi Maria-Valeria , Boziki Marina-Kleopatra , Siokas Vasileios , Aloizou Athina-Maria , Dardiotis Efthimios , Grigoriadis Nikolaos
Published: April 2022

Body dysmorphic disorder (BDD) is characterized by an individual’s preoccupation with a perceived defect in their appearance which to others may be barely noticeable or even completely unnoticed. It confers significant disturbances of everyday functioning in affected persons. The present review study provides an overview of neuroimaging findings on BDD. Literature on three platforms, PubMed, Google Scholar and PsycArticles of APA PsycNet, was searched for studies on patients with BBD compared with healthy controls (HCs), with a focus on neuroimaging findings. Out of an initial yield of 414 articles, 23 fulfilled inclusion criteria and were reviewed. Among the most remarkable findings were functional abnormalities in visual processing, frontostriatal and limbic systems, reduced global efficiency of White Matter (WM) connectivity, reduced cortical thickness in temporal and parietal lobes, and correlations between these neuroimaging findings and clinical variables such as symptom severity and degree of insight. Structural, volumetric and functional neuroimaging findings in BDD affected persons may help shed light on the pathophysiology and neurobiological underpinnings of this condition. Future studies should further investigate the use of imaging findings as potential prognostic biomarkers of treatment efficacy and disease outcome.
A review of autophagy mechanism of statins in the potential therapy of Alzheimer’s disease
Authors: Liu Lu , Dai Wen-Zhuo , Zhu Xi-Chen , Ma Tao
Published: April 2022

Alzheimer’s disease (AD) is a neurodegeneration csharacterized by amyloid-β (Aβ) deposition and abnormally phosphorylated Tau protein aggregation. Autophagy, as an important cellular metabolic activity, is closely related to the production, secretion and clearance of Aβ peptide and Tau phosphorylation level. Therefore, autophagy may become a potential target for AD treatment. A large number of molecules are involved in the mammalian target of rapamycin (mTOR)-dependent or mTOR-independent pathway of autophagy. More and more evidences show that statins can intervene autophagy by regulating the activity or expression level of autophagy-related proteins and genes. On the one hand, statins can induce autophagy through Sirtuin1 (SIRT1), P21, nuclear P53 and adenylate activated protein kinase (AMPK). On the other hand, statins inhibit the mevalonate metabolism pathway, thereby interfering with the prenylation of small GTPases, leading to autophagy dysfunction. Statins can also reduce the levels of LAMP2 and dynein, destroying autophagy. In this review, we focused on the role of autophagy in AD and the autophagy mechanism of statins in the potential treatment of AD.
Investigation of the optimal dose for experimental lipopolysaccharide-induced recognition memory impairment: behavioral and histological studies
Authors: Alzahrani Noor Ahmed , Bahaidrah Khulud Abdullah , Mansouri Rasha Abdulrashed , Alsufiani Hadeil Muhanna , Alghamdi Badrah Saeed
Published: April 2022

Background: Lipopolysaccharide (LPS) administration is one of the most commonly used methods for inducing inflammation in animal models. Several animal studies have investigated the effects of acute and chronic peripheral administration of LPS on cognitive impairment. However, no previous study has compared the effects of different doses of chronically administered LPS on recognition memory performance. Aim: Here, we aimed to investigate the optimal dose of chronically administered LPS for the induction of recognition memory impairment in mice. Materials and methods: LPS at different doses (0.25, 0.50 and 0.75 mg/kg) was administered to SWR/J mice daily for 7 days. On day 9, the open field, novel object recognition and novel arm discrimination behavioral tests were performed. Additionally, prefrontal cortical histological examination was conducted. Results: Compared with the control group, mice injected with 0.75 mg/kg LPS notably showed no object preference (familiar vs. novel), a reduction in the discrimination index, and spatial recognition impairment. Administration of the 0.25 and 0.50 mg/kg doses of LPS showed a preference for the novel object compared with the familiar object, had no significant impact on the discrimination index, and caused spatial recognition impairment. These behavioral results are in line with the histological examination of the prefrontal cortex, which revealed that the 0.75 mg/kg dose produced the most histological damage. Conclusions: Our findings suggest that for chronic peripheral administration of LPS, 0.75 mg/kg is the optimal dose for inducing neuroinflammation-associated recognition memory deficits.
Presence of enlarged perivascular spaces is associated with reduced processing speed in asymptomatic, working-aged adults
Authors: Ghazali Mazira Mohammad , Che Mohd Nassir Che Mohd Nasril , Idris Nur Suhaila , Chilla Geetha , K.N. Bhanu Prakash , Mustapha Muzaimi
Published: April 2022

Background: Enlarged perivascular spaces (ePVS) and white matter hyperintensities (WMHs) are recognised neuroimaging lesions for symptomatic and/or occult cerebral small vessel disease (CSVD) that are linked with the predisposition to cardiocerebrovascular risk and neurocognitive impairment. This study aimed to determine the interrelation between the WMHs and ePVS, neurocognition, and cardiocerebrovascular risk profiles in asymptomatic working-aged adults at a single-center population-based cohort. Methods: Fifty-four asymptomatic subjects (mean age: 39.6 ± 11.6 years) with low-to-moderate cardiocerebrovascular risk measured by QRISK3 prediction score were recruited and underwent neurocognitive evaluation and 3T MRI brain scan. Contour plot with multiple logistic and linear regression were utilized to study the interrelation between the variables. Results: The presence of WMHs and ePVS was associated with hypertension, systolic blood pressure, QRISK3 score, and age, whereby asymptomatic older subjects had higher prevalence for WHMs and ePVS (mean age: WMHs [46.6 ± 12.2 years]; ePVS [43.12 ± 12.2 years]). Higher ePVS load and reduced hippocampal volume among ePVS subjects was associated with reduced processing speed (odd ratio, 1.06; 95% confidence interval: 1.00 to 1.13) and reduced working memory performance (standardized β coefficients, −0.46 [95% CI: 0.46 to 12.1], p < 0.05), respectively. Conclusions: Albeit from a single center in the suburban east coast peninsular Malaysia, this study is to first from the region to highlight the subtle impacts of occult CSVD manifestations (WMHs and ePVS) on some aspects of neurocognition in an otherwise asymptomatic, relatively young working-aged adults with low-to-moderate cardiocerebrovascular risk scores.
Blood flow restriction exercise of the tibialis anterior in people with stroke: a preliminary study
Authors: Kjeldsen Simon Svanborg , Næss-Schmidt Erhard Trillingsgaard , Lee Michael , de Oliveira Camila Quel , Nielsen Jørgen Feldbæk , Stubbs Peter William
Published: April 2022

Background: Blood flow restriction exercise (BFR-E) could be a useful training adjunct for patients with weakness after stroke to augment the effects of exercise on muscle activity. We aimed to examine neurophysiological changes (primary aim) and assess patient perceptions (secondary aim) following BFR-E. Methods: Fourteen participants with stroke performed BFR-E (1 session) and exercise without blood flow restrictsion (Exercise only) (1 session), on two days, ≈7 days apart. In each session, two sets of tibialis anterior (TA) contractions were performed and electromyography (EMG) was recorded. Eight participants underwent transcranial magnetic stimulation (single-pulse stimulation, short interval intracortical inhibition (SICI), intracortical facilitation (ICF)) and peripheral electrical stimulation (maximal peak-to-peak M-wave (M-max)) of the TA before, immediately-after, 10-min-after and 20-min-after BFR-E and Exercise only. Numerical rating scores (NRS) for pain, discomfort, fatigue, safety, focus and difficulty were collected for all subjects (n = 14). Paired comparisons and linear mixed models assessed the effects of BFR-E and Exercise only. Results: No adverse events due to exercise were reported. There was no contraction-number × condition interaction for EMG amplitude during exercise (p = 0.15), or time × condition interaction for single-pulse stmulation, SICI, ICF or M-max amplitude (p = 0.34 to p = 0.97). There was no difference between BFR-E and Exercise only in NRS scores (p = 0.10 to p = 0.50). Conclusion: Using our training paradigm, neurophysiological parameters, feasibility, tolerability and perceptions of safety were not different between BFR-E and Exercise only. As participants were generally well-functioning, our results are not generalizable to lower functioning people with stroke, different (more intense) exercise protocols or longer term training over weeks or months.
Identification of a novel immune-related lncRNA signature to predict prognostic outcome and therapeutic efficacy of LGG
Authors: Wu Dongdong , Wang Xuning , Xue Yonggan , Sun Caihong , Zhang Meng
Published: April 2022

Background: Recent studies have shown that the prognosis of low-grade glioma (LGG) patients is closely correlated with the immune infiltration and the expression of long-stranded non-coding RNAs (lncRNAs). It’s meaningful to find the immune-related lncRNAs (irlncRNAs). Methods: The Cancer Genome Atlas (TCGA) data was employed in the study to identify irlncRNAs and Cox regression model was applied to construct the risk proportional model based on irlncRNAs. Results: In the study, we retrieved transcriptomic data of LGG from TCGA and identified 10 lncRNA signatures consisting of irlncRNAs by co-expression analysis. Then we plotted 1-year receiver operating characteristic (ROC) curves and calculated the area under the curve (AUC). LGG patients were divided into high-risk and low-risk groups according to the risk model. We found there were differences in survival prognosis, clinical characteristics, degree of immune cell infiltration, expression of immune gene checkpoint genes, and sensitivity to the commonly used chemotherapeutic agents of high-risk and low-risk groups. Conclusions: IrlncRNA-based risk assessment model can be used as a prognostic tool to predict the survival outcome and clinical characteristics of LGG and to guide treatment options.
Impact of a 12-month multifaceted neurological physiotherapy intervention on gross motor function in women with Rett syndrome
Authors: Kapel Alen , Kovacic Tine , Kos Natasa , Velnar Tomaz
Published: April 2022

Background: Rett syndrome is a rare genetic neurological syndrome that affects mostly females. The syndrome leads to severe impairments impacting all areas of the affected persons’ life, including speech, mobility, eating, and breathing impairments. The most distinct symptoms include stereotyped hand movements, ataxia, and atrophy of the lower limbs, and signs of autism. Methods: According to the principle of convenience sampling, the quantitative research included five females diagnosed with Rett syndrome subject to their personalized goal oriented neurological physiotherapy. Changes in gross motor function were assessed by the Gross Motor Function Measure 88 and Rett syndrome Gross Motor Scale. Results: It was found that the 12-month multifaceted neurological physiotherapy intervention had statistically significant improvements in both Gross Motor Function Measure 88 (p = 0.005) and Rett syndrome Gross Motor Scale (p = 0.012). Despite positive improvements, the absence of control group made it difficult for a comparative evaluation to determine what interventions had the best possible outcomes. Conclusions: The quantitative research demonstrates neuro-developmental treatment sessions, hippotherapy, hydrotherapy, physical therapy, a walking program, endurance exercises, active-assisted exercises, and coordination exercises, had a significant impact on improving gross motor function status. Current multifaceted intervention program leads to good improvement of gross motor skills above what can be expected from late motor deterioration.