bluuebunny/crossref_metadata_2025 huggingface dataset:
Racial and ethnic variation in COVID-19 care, treatment, and outcomes: A retrospective cohort study from the MiCOVID-19 registry
Authors: Sutton Nadia R. , Robinson-Lane Sheria G. , Yeow Raymond Y. , Chubb Heather A. , Kim Tae , Chopra Vineet
Published: November 2022

Background

Racial and ethnic disparities in COVID-19 outcomes exist, but whether in-hospital care explains this difference is not known. We sought to determine racial and ethnic differences in demographics, comorbidities, in-hospital treatments, and in-hospital outcomes of patients hospitalized with COVID-19.

Methods and findings

This was a cohort study using MiCOVID-19, a multi-center, retrospective, collaborative quality improvement registry, which included data on patients hospitalized with COVID-19 across 38 hospitals in the State of Michigan. 2,639 adult patients with COVID-19 hospitalized at a site participating in the MiCOVID-19 Registry were randomly selected. Outcomes included in-hospital mortality, age at death, intensive care unit admission, and need for invasive mechanical ventilation by race and ethnicity. Baseline comorbidities differed by race and ethnicity. In addition, Black patients had higher lactate dehydrogenase, erythrocyte sedimentation rate, C-reactive protein, creatine phosphokinase, and ferritin levels. Black patients were less likely to receive dexamethasone and remdesivir compared with White patients (4.2% vs 14.3% and 2.2% vs. 11.8%, p < 0.001 for each). Black (18.7%) and White (19.6%) patients experienced greater mortality compared with Asian (13.0%) and Latino (5.9%) patients (p < 0.01). The mean age at death was significantly lower by 8 years for Black patients (69.4 ± 13.3 years) compared with White (77.9 ± 12.6), Asian (77.6 ± 6.6), and Latino patients (77.4 ± 15.5) (p < 0.001).

Conclusions

COVID-19 mortality appears to be driven by both pre-hospitalization clinical and social factors and potentially in-hospital care. Policies aimed at population health and equitable application of evidence-based medical therapy are needed to alleviate the burden of COVID-19.
Health professionals and scientists’ views on genome-wide NIPT in the French public health system: Critical analysis of the ethical issues raised by prenatal genomics
Authors: Perrot Adeline , Horn Ruth
Published: November 2022

In France, since January 2020, laboratories have started to make available genome-wide Non-Invasive Prenatal Testing (GW-NIPT) beyond the three common trisomies (T21, T13 and T18) at the same cost as standard NIPT. With the possible margins for interpretation of the legal framework and in the absence of clear and updated guidelines, health professionals are left with questions about which type of screening offer may be clinically responsible, morally appropriate, and, at the same time, respectful of women’s values and ability to make autonomous choices. The aim of this study is to provide an analysis and understanding of the challenging dimensions of clinical practices in the context of evolving scientific knowledge and techniques in prenatal genomics. In this article, we develop a critical analysis of the arguments and concerns that emerge around the offer of expanded NIPT and are discussed by health professionals and scientists. To achieve this, we conducted qualitative semi-structured interviews with 17 health professionals and scientists from September 2021 to February 2022 and a comprehensive literature review (regulatory, scientific, medical, institutional sources). The results of our empirical research highlight the importance of addressing ethical issues related to the differing quality of counselling, the complexity of achieving informed consent, and the avoidance of harm to pregnant women in the feedback of findings beyond T21, T18 and T13. If there is an increase in the provision of GW-NIPT within the French public health system, it will be essential to promote medical practices that respect reproductive choices of women, support their autonomous decision and their understanding of the limitations and uncertainties associated with GW screening. Further research is required to provide an insight into women’s perceptions in order to refine our analysis from the patients’ perspective.
Post-infectious basal ganglia encephalitis and axonal variant of Guillain-Barré syndrome after COVID-19 infection: an atypical case report
Authors: Yang Jiwon , Shin Dong-Jin , Park Hyeon-Mi , Lee Yeong-Bae , Sung Young-Hee
Published: November 2022

Neurological complications attributed to coronavirus disease-19 (COVID-19) infection have been reported including acute disseminated encephalomyelitis, Guillain-Barré syndrome, and so on. Herein, we report a 49-year-old woman presented with acute encephalopathy and paraplegia simultaneously after COVID-19 infection. Brain magnetic resonance imaging (MRI) showed symmetric hyperintense basal ganglia lesions on T2-weighted imaging. Cerebrospinal fluid pleocytosis, motor axonal neuropathy and enhancement of conus medullaris nerve roots on spine MRI were observed. We treated her with high-dose corticosteroid and intravenous immunoglobulin.
Diagnosis of complex regional pain syndrome
Authors: Kim Young-Do
Published: November 2022

Complex regional pain syndrome (CRPS) is a chronic regional pain disorder that most frequently affects the limbs. It is characterized by hyperalgesia, allodynia, edema, motor disturbance, and vasomotor instability, and typically occurs following surgery or trauma. In type-I CRPS there is no confirmed nerve injury, while peripheral nerve injury is present in type-II CRPS. The multifactorial pathophysiological etiology of CRPS includes inflammation, autoimmune responses, abnormal cytokine production, autonomic dysfunction, altered blood flow, psychological factors, and central cortical reorganization. There are no specific laboratory diagnostic tools for CRPS, and so it is diagnosed clinically. The Budapest criteria are currently the most-accepted diagnostic criteria.
Repetitive transcranial magnetic stimulation for neuropathic pain
Authors: Kim Sooyoung , Lee Eun Kyoung , Sohn Eunhee
Published: November 2022

Noninvasive stimulation of the nervous system for treating chronic neuropathic pain has received attention because of its tolerability and relative efficacy. Repetitive transcranial magnetic stimulation (rTMS) is a representative method of noninvasive brain stimulation. Evidence-based guidelines on therapeutic use of rTMS have been proposed recently for several neurological diseases. These guidelines recommend treating neuropathic pain by applying high-frequency (≥ 5 Hz) rTMS to the primary motor cortex contralateral to the painful side. This review summarizes the mechanisms and guidelines of rTMS for treating neuropathic pain, and proposes directions for future research.
Class C fly ash as a substitute for mineral fillers in asphalt mixtures
Authors: Ali Sajjad , Siddiqui Dr. Muhammad Owais Raza , Noman Syed Muhammad , Beg Tahreem , Sun Danmei
Published: November 2022

The influence of class C fly ash as a substitute for mineral aggregate on the stability and density of asphalt mixtures containing 3.5−6 wt% of bitumen was investigated. For the fly ash concentration (in relation to the replaced aggregate) 25, 50, 75 and 100 wt%, the optimal asphalt content (OAC) was determined, respectively, 5.75, 4.82, 4.42, 4.4 and 4 wt%. The stability increased with the increase in the content of fly ash. The results confirm the possibility of replacing mineral aggregates with fly ash.
Invited discussant comments during the UCL–Penn Global COVID Study webinar ‘How Do We Trust (Again): Paranoia and Mental Health’: part 1 of 2
Authors: Barkus Emma
Published: November 2022

The article provides commentary on Wong et al.’s investigation of the relationship between schizotypal traits, social mistrust and aggression, mental and physical health outcomes across three waves of data collection commencing in April 2020. The researchers aimed to consider the nature of the relationship between these variables and the stability of these relationships as coronavirus (Covid-19) restrictions fluctuated over time. Their results suggested that loneliness reflects a hub which links the trait variables of schizotypal and social mistrust to aggression and mental and physical health symptoms. Their network did not vary by demographic factors nor wave of data collection, suggesting that stable individual differences were driving results. Their results propose that interventions which increase social connection could provide positive health benefits as well as decreasing aggression (via reductions in social mistrust). Their data contributes to understanding about how schizotypal traits link to outcomes under conditions of social stress.
PENERAPAN PENDEKATAN POSITIVISTIK DALAM PENELITIAN HUKUM ADAT
Authors: Pradhani Sartika Intaning , Sari Almonika Cindy Fatika
Published: November 2022

Pendekatan positivistik terhadap hukum adat yang melahirkan ilmu hukum adat positif dianggap membuat studi hukum adat bersifat statis. Tulisan ini bertujuan menggali penggunaan nalar positivistik dalam penelitian hukum adat dan menjawab kontribusi nalar positivistik terhadap perkembangan studi hukum adat. Penelitian ini merupakan penelitian hukum normatif yang menggunakan laporan penelitian normatif empiris tentang hukum adat sebagai basis datanya. Pendekatan positivistik ternyata tidak membuat kajian hukum adat menjadi ajek/statis. Realitas lapangan yang dinamis berkontribusi untuk memutakhirkan konsep-konsep hukum adat yang telah mapan. Sebagai contoh bidang tanah adat perseorangan yang dapat dijual lepas mengkritisi konsep inalienablility tanah ulayat dan anak perempuan dari kekerabatan patrilineal dapat mewaris harta ayahnya juga mengkritisi konsep anak perempuan bukan merupakan ahli waris dalam kekerabatan patrilineal.
PERBEDAAN PERLINDUNGAN PRIVASI KONSUMEN DI INDUSTRI KEUANGAN DAN NON-KEUANGAN
Authors: Johan Suwinto
Published: November 2022

Penggunaan media sosial telah meningkat secara masif. Akun media sosial atau nomor telepon merupakan hak privasi konsumen. Penjualan data pribadi konsumen telah meningkat pesat. Penelitian ini bertujuan membahas perlindungan privasi konsumen terhadap promosi penjualan Penelitian membahas perlindungan privasi industri keuangan dan non-keuangan. Penelitian ini mempergunakan metode legal normatif. Penelitian ini menyimpulkan bahwa pemerintah harus mampu mengatur penggunaan data pribadi konsumen secara komprehensif. Penggunaan data pribadi ini harus meliputi penggunaan, pelaksanaan dan pengawasan data pribadi konsumen. Peraturan penggunaan data pribadi harus merupakan peraturan yang mengatur keseluruhan data pada saat ini dan masa yang akan datang. Industri non-keuangan belum diatur oleh regulator terkait.
Delegitimisation of Indonesian Traditional Leaders: An Analysis in Minangkabau, West Sumatra Province
Authors: Asrinaldi Asrinaldi
Published: November 2022

It is argued that an excessive euphoria of autonomy was the primary consequence of the first five years of decentralisation in Indonesia after the New Order. The euphoria of autonomy led to the emergence of ethnic nationalism perpetuated by traditional powers that regulated the control and exploitation of natural resources. The New Order government tried to control local democratic practices by weakening traditional leaders' legitimacy. This article explains how this reality occurs in West Sumatra Province. First, based on village and regional government laws following the New Order, local democracy led to the delegitimisation of traditional power. Second, the systematic implementation of local democracy erased the traditional leadership authority that relegated the Minangkabau ethnic and traditional values. It was concluded that the government enacted the local government and village laws to regulate the traditional authority.
Estimation and Confidence Intervals of Modified Process Capability Index Using Robust Measure of Variability
Authors: Saha Mahendra , Dey Sanku
Published: November 2022

The process capability index (PCI), denoted by 𝐼, is a well-known characteristic in quality control analysis.
Using Gini’s mean difference, we construct a new PCI,

I
G

I_{G}

say, assuming the two-parameter Weibull distribution (WD).
In order to estimate the proposed

I
G

I_{G}

when the process follows the WD, we use five classical methods of estimation and compare the performance of the obtained estimators with respect to their mean squared errors (MSEs) through a simulation study.
Confidence intervals for the proposed PCI are constructed based on five bootstrap confidence intervals (BCIs) methods.
Monte Carlo simulation study has been carried out to compare the performance of these five BCIs in terms of average widths and coverage probabilities.
Finally, three real data sets from electronic and food industries are employed for illustrating the effectiveness of the proposed study.
All these data sets show that the width of bias-corrected accelerated bootstrap interval is minimum among all other considered BCIs.
Adolescent mental health during covid-19 pandemics: a systematic review
Authors: Alamolhoda Seideh Hanieh , Zare Elham , Atena HakimZadeh  , Zalpour Asma , Vakili Fatemeh , Razie Mohammadi Chermahini  , Ebadifard Reyhane , Masoumi Masoumeh , Niayesh Khaleghi  , Malihe Nasiri
Published: November 2022

Objectives

The outbreak of the COVID-19 pandemic has had wide-ranging outcomes on adolescents’ well-being. However, less attention has been paid to the adolescent’s mental health during the pandemic. The pandemic may impair adolescents’ mental health through stress spillover from other family members, contextual and policy changes, and the disruption of everyday life routines. Therefore, our research is motivated by a need to address the relative scarcity of research examining adolescent mental health during the pandemic.

Content

This systematic review was conducted through the medical database, Web of Science, Scopus, Medline, Embase, Google Scholar, and Cochrane databases for peer-reviewed, cross-sectional, cohort studies assessing the mental health status of adolescents during the Covid-19 virus pandemic from May 2020 till Dec 2022 without language restriction. Keywords were selected based on the Mesh terms and Emtree.

Studies on coronavirus have revealed many significant psychological effects on teens of all ages. The most commom problems were on the stress and anxiety, sleep disorders, depression, post-traumatic stress disorder. Risk factors were concidered as prior mental health problem, female sexuality, fear of covid-19, nutrition, physical activity and listening the covid 19 news.

Outlook

Considering the critical age of teenagers, the role of parents is vital. Health policy maker should support parents as a key factors to approprate care for adolescent. Parents should be educated on parenting methods during the covid pandemic to avoid irreparable damage of adolescent’s mental health.
A class of piecewise fractional functional differential equations with impulsive
Authors: Jia Mei , Li Tingle , Liu Xiping
Published: November 2022

In this paper, we study a class of piecewise fractional functional differential equations with impulsive and integral boundary conditions. By using Schauder fixed point theorem and contraction mapping principle, the results for existence and uniqueness of solutions for the piecewise fractional functional differential equations are established. And by using cone stretching and cone contraction fixed point theorems in norm form, the existence of positive solutions for the equations are also obtained. Finally, an example is given to illustrate the effectiveness of the conclusion.
Beyond Labourer’s Love: Rethinking Early Chinese Film Comedy
Authors: Huang Xuelei
Published: November 2022

This article examines three lost short comedies produced alongside Labourer’s Love by the Mingxing Film Studio in 1922: The King of Comedy Visits Shanghai (Huaji dawang you hu ji), Havoc in a Bizarre Theatre (Danao guai xichang), and The Naughty Kid (Wantong). I propose to look beyond the extant Labourer’s Love and instead to delve into the broader intertextual, intermedial fabric of early film comedy for a re-evaluation of this neglected genre. Drawing on advertising texts, stills, and film reviews, this study corrects misinformation and supplements new data, based on which I posit two notions for a reconceptualization of early Chinese comedy film. First, I propose the Chinese concept of renao (“hot noise”) as a particular sensorial-somatic mode of experience to account for the Chinese engagement with film comedy in the tumultuous 1920s. Second, I borrow the Chinese poetic device of allusion to interpret their widespread references to Hollywood films in structural, narrative, and visual terms. Through the prism of allusion, the appropriation and re-production of Hollywood elements can be regarded as a means of adding authority to inchoate Chinese filmmaking, while at the same time complicating familiar topoi, symbols, and imageries in culturally sensitive ways.
Thyroid storm in pediatrics: a systematic review
Authors: Abisad Daniela Aguilar , Glenn Lecea Eva Maria , Ballesteros Andrea Montano , Alarcon Guido , Diaz Alejandro , Pagan-Banchs Pedro
Published: November 2022

Objectives

Thyroid storm (TS) is an uncommon but severe manifestation of hyperthyroidism and an endocrine emergency, as it is fatal if it goes unrecognized. In pediatrics, the current literature is limited to case reports and case series. Current knowledge is extrapolated from adult data. This systematic review aims to present the epidemiology, most common etiologies, clinical presentation, and most accepted standard of care of TS in children. We aim to raise awareness of hyperthyroidism in the pediatric community.

Content

The databases used were PubMed, google scholar, and LILACS, with the search terms “thyroid storm” AND “pediatrics”. Studies included case reports and case series in English and Spanish from patients between the ages of 0–21 years with clinical features consistent with a diagnosis of TS based on ATA 2016, with or without reported scale scores, published between 2000 and 2022. Variables such as ethnicity, etiology, possible triggers, clinical features, and management components were analyzed and presented.

Summary

We analyzed data from 45 patients. Their mean age was 11.25 years. The majority of them were from Asia (26%). The most common clinical features were sinus tachycardia (86.7%) and fever (64%), followed by altered mental status (46%) and diarrhea (31%). Graves’ disease was the most common underlying condition, and infection the most common precipitant. Thirty one percent of patients received treatment with four components; however morbidity and mortality were not clinically significant with those who did not. TS has a heterogeneous presentation with multisystemic involvement. The most common symptoms in this review were fever, tachycardia, diarrhea, and altered mental status.

Outlook

Further studies may be needed to best standardize the diagnosis and management of TS in children. Qualitative studies are needed to best assess the delay in diagnosis of hyperthyroidism and how this may impact prognosis in case patients were to develop TS.
Affectedness and Differential Object Marking in Turkish and Uzbek
Authors: Kizilkaya Semra , Levy-Forsythe Zarina , von Heusinger Klaus
Published: November 2022

This article explores the relationship between affectedness and Differential Object Marking (DOM) of indefinite direct objects in Turkish and Uzbek. We argue that the distribution of DOM in the two Turkic languages is determined by the direct objects’ specificity and animacy as nominal semantic properties, and affectedness as a verbal semantic property associated with the direct object. We provide original empirical evidence from two forced-choice studies that investigate DOM along the parameters of animacy, affectedness, and telicity, and their interaction with each other. Our findings indicate that affectedness shapes the distribution of DOM in both Turkish and Uzbek, with an interesting variation in how it is instantiated and interacts with animacy. The findings do not confirm an impact of telicity as an independent factor driving overt case marking in the languages investigated. Rather, its influence on DOM stems from interaction with affectedness.
Non-coding repeat expansions associated with familial adult myoclonic epilepsy: a new paradigm of gene-independent monogenic disorders
Authors: Kühnel Theresa , Depienne Christel
Published: November 2022

Familial adult myoclonic epilepsy (FAME) is a rare autosomal dominant disorder characterized by cortical myoclonic tremor and seizures. FAME has been mapped to chromosomes (chr) 2, 3, 5 and 8, but the cause has remained elusive for more than a decade. An expansion of intronic TTTTA and TTTCA repeats in SAMD12 was identified as the cause of FAME1 in Japanese families linked to chr 8 in 2018. This discovery triggered the identification of identical repeat expansions at five additional loci (FAME2: STARD7; FAME3: MARCHF6; FAME4: YEATS2; FAME6: TNRC6A and FAME7: RAPGEF2). These genes encode proteins with different functions and subcellular localizations and their expression is unaltered in available peripheral tissues, suggesting that the expansion is pathogenic independently of the gene itself. The pathophysiological mechanisms are not yet known but possibly include toxicity at the RNA level or translation of toxic polypeptides from the repeats, a mechanism known as repeat-associated non-AUG (RAN) translation. FAME is a paradigm of human genetic disorder caused by a non-coding expansion unrelated to the gene where it occurs.
ENTRE A MAQUETE DE ESTUDOS, JOGOS EDUCATIVOS E PLATAFORMAS GOOGLE
Authors: Tischer Wellington , Da Rocha Heck Adalberto
Published: November 2022

O presente artigo analisa a experiência do ateliê integrado nas disciplinas de Planejamento Urbano e Projeto Arquitetônico voltado à Habitação de Interesse Social (HIS). A interface entre essas disciplinas se deu em um contexto de promoção e uso dos vazios centrais à luz do Estatuto da Cidade de 2015 a 2018 em um curso noturno de graduação em Arquitetura e Urbanismo na Faculdade Empresarial de Chapecó (UCEFF), em Chapecó (SC). O artigo discute o processo de ensino-aprendizagem em pequenas e médias cidades brasileiras com a inserção de inovação pedagógica, como as plataformas Google e o Jogo do Estatuto da Cidade, e sua relação com métodos tradicionais como o trabalho em ateliê com assessoramento por maquetes de estudo, saídas de campo e seminários de estudos de caso. Apresenta-se um roteiro para ser utilizado em análise de estudos de caso e elaboração de Projetos de Conjuntos Habitacionais de HIS.
PELOS USOS MENORES
Authors: Heinemann Rodeghiero Thiago
Published: November 2022

Este artigo versa sobre o fazer artístico de pequeno território de artista e suas imbricações conceituais. Coloca-se a formulação de minoridade de Gilles Deleuze e Félix Guattari a fazer composição com a série de trabalhos artísticos do pequeno território e das práticas banais de artista. Tal análise se justifica ao pensar a cidade, em suas frestas e brechas, como potência artística. Desterritorializada, política e coletiva, a minoridade das práticas em arte-cidade surge como intensidades do plano de consistência deste artigo. O método que constrói esse texto é feito ao modo de uma cartografia deleuzeguattariana e explorada através das pistas e dos signos de processualidade oriundas dos meios e trajetos existenciais percorridos.
Calculating Self-concept Structure Indices, Including Linville’s H: Toward Standardization and Replication
Authors: Smyth Lillian , Banas Kasia , Mavor Kenneth I.
Published: November 2022

The structure of the self and its relationship with wellbeing are of interest to researchers in many areas of psychology, including social, clinical and differential. Psychologists seeking to calculate the self-concept structure indices associated with the self-complexity framework have long been faced with a computation bottleneck. The complex formulae, variable approaches and lack of availability of ready-to-use programs that allow streamlined calculation of dimensionality (Linville’s H), complexity (Sakaki’s SC), overlap (OL) and compartmentalisation (Shower’s Phi) means that the research area has been limited in both research speed and participation. The low volume of studies and the computational disincentive for replications have led to a situation where the evidence on self-complexity and related constructs is equivocal. In this article, we discuss approaches to calculating self-concept structure, providing a practical guide for researchers who would like to implement the published formulas or use existing computational tools, made available by the authors. This tutorial will allow both efficiency and broader access for researchers seeking to examine constructs related to self-concept structure. We hope that these contributions might foster a new wave of data collection in this area, allowing for clarity on the utility and implications of dimensionality and complexity in the self-concept.
Changing Times
Authors: Birch Jennifer
Published: November 2022

Recent radiocarbon redating of key sites and events in Huron-Wendat archaeology has shaken dominant accounts of early colonial history. This paper emphasizes the importance of storytelling in archaeology. I consider how refined date estimates for key Huron-Wendat archaeological sites have impacted understandings of conflict, confederacy-formation, and the reception (or not) of early European materials and persons. The paper highlights how this work affects processes of commemoration and collaboration, as well as the importance of shared authority and Huron-Wendat leadership in rewriting contact-era archaeological histories. This project has generated productive new directions for meaningful collaboration between archaeologists and Indigenous researchers and heritage managers.
Quality Analysis of E-KTP Services at the Department of Population and Civil Registration of Semarang Regency
Authors: Pangestu️ Aji
Published: November 2022

This study aimed to analyze the quality of e-KTP services at the Department of Population and Civil Registration (Dukcapil) of Semarang Regency. This research used descriptive qualitative research. Informants in this study were 14 informants consisting of 4 apparatus and 10 service users. Data collection techniques used observation, interviews and documentation. Data analysis used data collection, data reduction, data presentation and drawing conclusions. The results of the study indicated that in the Tangible dimension, there were two indicators that were not optimal, namely the ease of service processes and the use of service tools. In the Reliability dimension, there was one indicator that was not optimal, namely having clear service standards. In the Assurance dimension (Guarantee), there was one indicator that was not optimal, namely providing guarantees on time. Meanwhile, the Responsiveness and Empathy dimensions had been said to be optimal in the application of each indicator. The conclusion from this study, the implementation of e-KTP services at Dukcapil Semarang Regency had not been fully optimal, as evidenced by the existence of indicators that had not been implemented properly. The advice given is to be able to provide facilities in the form of providing service officers who stand by near the entrance to the service room so that it is easy to reach, always improve the quality of service aids, especially for tools that often have problems, adjust to the circular letter of Presidential Regulation number 96 of 2018, coordinate further related to the distribution of e-KTP with the POS office in order to minimize delays.
Pentingnya Penggunaan Merek Untuk Produk Makanan Ringan (Keripik) Bagi Masyarakat
Authors: Berlianty Teng , Balik Agustina , Demmatacco Triska
Published: November 2022

The use of brands on the packaging of snack products (chips) to mark the product, as a means of promotion, to show the quality of the product and the origin of the product. Legal counseling on trademarks was delivered by a lecturer in the civil section of the Unpatti Faculty of Law to the Wotay Village community as an effort to provide education on the importance of using brands. In addition, using a mark provides guarantees of legal protection for business actors/mark owners through online trademark registration at the Ministry of Law and Human Rights, Directorate General of Intellectual Property Rights.
The Efficacy of Nitrite Therapy for the Treatment of Heart Failure: A Meta-Analysis of Randomized Controlled Trials
Authors: Zhou Quan , Zhang Qin , Xu Huaqiang
Published: November 2022

Introduction: The efficacy of nitrite therapy for the treatment of heart failure remains controversial. We conducted a systematic review and meta-analysis to explore the impact of nitrite therapy on heart failure.
Methods: We searched the PubMed, EMbase, Web of Science, EBSCO, and Cochrane Library databases through November 2019 for randomized controlled trials (RCTs) assessing the effect of nitrite therapy on heart failure. This meta-analysis was performed using the random-effect model.
Results: Three RCTs are included in the meta-analysis. Overall, compared with the control group for heart failure, nitrite therapy is associated with significantly reduced PCWP (Std. MD=-1.22; 95% CI=-1.81 to -0.63; P < 0.0001) and improved PAC (Std. MD=0.71; 95% CI=0.16 to 1.27; P = 0.01), but reveals no substantial influence on peak VO2 (Std. MD=-0.19; 95% CI=-0.49 to 0.11; P = 0.21), systolic BP (Std. MD=-3.98; 95% CI=-8.24 to 0.28; P = 0.07), mean BP (Std. MD=-1.53; 95% CI=-3.37 to 0.31; P = 0.10), or heart rate (Std. MD=0.40; 95% CI=-0.14 to 0.94; P = 0.15).
Conclusions: Nitrite therapy may show some benefits to heart failure.
Regulations of Social Capital Formation in Ukraine: Theoretical Framework and International Context
Authors: ZVONAR V. P. , DYAKONENKO O. I. , SOVA O. Yu.
Published: November 2022

In the paper, the regularities of the formation of social capital as a component of the problem of capitalization of social interaction have been studied. The methodological approach of the research includes two aspects: theoretical, the purpose of which is to substantiate the theoretical structure of the regularities of the formation of social capital; analytical, according to which the manifestation of the revealed regularities in Ukraine and other countries has been assessed. Four main regularities have been considered (empathy, risk reflectivity, migration impact, norm correspondence), which determine the functioning of the essential elements of social capital, as well as the features of transformation and conversion of its forms. The selection of proper economic indicators that reflect trends in the manifestation of social capital formation has been performed. The results of analytical assessment of the actualization of the specified regularities in Ukraine compared to other countries have been presented. The research revealed that empathy, as a relationship between rationality and sociality of human interaction, constitutes a solid foundation for the development of social capital and has the most vivid and positive manifestations in Ukrainian society when economic agents readily and carefully respond to the needs of their counterparts in social relations. The paper demonstrates the features of the differentiation of forms of social capital according to the direction of internal connections within social networks and the homogeneity (density) of social networks. The determinism of the variability of the forms of social capital is substantiated by the different perceptions of risks by the agents of social interaction. The low tolerance of Ukrainian economic agents to risk has been registered. This determines their preferences regarding participation in vertical and closed social networks. The relationship between migration (mobility) and social trust is revealed. It is argued that the relationship manifests itself in the generally ambiguous impact of immigration to Ukraine and emigration from Ukraine on the functioning of trust networks. This testifies to the possibilities and reserves of managing such an impact to increase social capital in the country. The objective relationship between trust in social norms (the degree of their social recognition and acceptance) and the productivity of social capital is specified. It has been observed that in Ukraine, a critically low level of trust in social norms and norm-setting institutions contributes to the development of corruption and destructive social networks.
Spatial clustering of substantia nigra astrocytes analyzed in rotenone model of hemiparkinsonism
Authors:   Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine, Nikonenko A.G.
Published: November 2022

This paper addresses spatial aspects of reactive astrogliosis in the substantia nigra pars compacta (SNc) of the rat brain observed 40 and 70 days after the intracerebral 12 µg rotenone infusion. The infusion was shown to cause a marked increase in astrocyte density at both analyzed time points. Minimal spanning tree (MST) analysis was applied to analyze spatial patterns formed by nigral astrocytes. Spatial clusters of these cells, identified as disjoint MST subgraphs, were more numerous in the infused SNc tissue as compared with the control one. Size and density of clusters were significantly different between the infused and control areas 40 and 70 days after the infusion. In conclusion, the data suggests that rotenone-related astrogliosis in the substantia nigra includes changes in spatial patterns of astrocytes as well as transient spatial clustering of these cells.
The Association between the rs35874116 Gene TAS1R2 Polymorphism with Caries Index
Authors: Mumtazdhia Pelangi , Maskoen Ani Melani , Laksono Bremmy , Ardini Witri
Published: November 2022

Background: Dental caries is a multifactorial disease influenced by complex genetic and environmental factors. At least 27 gene polymorphisms have been identified that are associated with caries risk. Polymorphisms of genes encoding taste receptors, such as the TAS1R2 gene, can cause individual differences in perception and sensitivity to sweet tastes. Research shows that the TAS1R2 gene polymorphism is associated with the consumption of sweet foods, which affects increasing caries risk. This study aims to determine the relationship between the TAS1R2 gene rs35874116 polymorphism and the caries index in Tangerang Selatan population. Methods: This study is observational with a cross-sectional method involving 266 research subjects (45 males and 221 females; 20-55 years). DNA was extracted from venous blood using the Genomic DNA Mini Kit from Geneaid and the genotyping process using the rhAmp-SNP assay kit, which was analyzed using RT-PCR. Dental caries was assessed by calculating D(decayed), M(missing), and F(filled) on permanent teeth. The hypothesis between the TAS1R2 genotype and the DMF-T index was tested using the Mann-Whitney test, while the comparison between the TAS1R2 genotype and caries risk was tested using Kruskal-Wallis' test. The results of the study were considered significant if p<0.05. Results: The minor allele frequency was 16.5%. The proportion of TT, TC, and CC genotypes were 71.%, 24.1%, and 4.5%, respectively. According to WHO classification, the DMF-T index of all research subjects was 5.62, a high category. The group of subjects with the CC genotype had a higher DMF-T index (7.08; very high) than the group of subjects with the CT genotype (6.05; high) and TT (5.38; high). CT and TT genotypes with high risk were significantly lower than those with low-moderate caries risk. Conclusion: there is no significant association between the TAS1R2 gene polymorphism rs35874116 with the caries index value in the people in South Tangerang.
Clinical Screening of Congenital Heart Disease in Neonates: a Literature Review on Five Studies
Authors: Pamungkas Bentito Zulyan , Widaryo Phaleno Pramasditomo
Published: November 2022

Background: Diagnosing Congenital Heart Disease (CHD), particularly critical CHD in newborns, could be difficult but crucial, since the field of congenital heart surgery has shifted from initial palliation followed by final correction at a later age to stressing early repair even in the youngest individuals. Although echocardiography remains the gold standard for diagnosing CHD, simple clinical examination may be helpful in screening neonates who require further investigation and treatment. In this study, we searched and reviewed the literature on clinical screening for CHD using a simple, affordable tool that is readily available in primary health care facilities, to prove that early simple clinical examination would help physician to screen for asymptomatic CHD.Methods: We searched articles on google scholars that discuss clinical screening of CHD in neonates. Inclusion criteria is articles published within five years and exclusion criteria is articles published older than five years.Results: We found five articles eligible and pick consecutively. We found that pulse oximetry sensitivity and specificity ranged from 21.54%-77.3% and 82.65%-99.9%, respectively. Cardiac auscultation with murmur of grade ≥2 as count as positive, having high range of sensitivity and specificity, with sensitivity ranged from 17.3%-89.58% and specificity ranged from 47.36%-99.69%. When pulse oximetry and cardiac auscultation combined, three studies found that the sensitivity and specificity increased dramatically, 89.9%-95.5%, 94.7%-99.37%, respectively. Conclusion: Both cardiac auscultation and pulse oximetry was an easy, feasible method with readily available basic tools at all hospital with acceptable sensitivity and specificity to screening CHD before suspected neonates undergo echocardiography, therefore making CHD diagnosed more effective and efficient.
Distribution Based Fuzzy Time Series Markov Chain Models for forecasting Inflation in Bandung
Authors: Pratiwi Salsabila Ayu , Rachmatin Dewi , Marwati Rini
Published: November 2022

This study discusses the application of the Fuzzy Time Series Markov Chain method which was developed by determining the length of the interval using the distribution method. In the fuzzy forecasting method, the determination of the length of the interval is an important thing that will affect the accuracy of the forecasting results. The development of this forecasting model aims to get better forecasting accuracy results. In this study, general inflation data for the city of Bandung is used for the period January 2016 – June 2021. The data is divided into two groups, namely in sample data and out sample data with a ratio of 90: 10. In the data processing process, the Python programming language is used. Based on the accuracy test using the MAPE method, it can be concluded that this method provides better forecasting results with a MAPE value of 1.16%.
On The Edge Irregularity Strength of Firecracker Graphs F2,m
Authors: Ramdani Rismawati , Suwandi Desi Laswati
Published: November 2022

Let  be a graph and k be a positive integer. A vertex k-labeling  is called an edge irregular labeling if there are no two edges with the same weight, where the weight of an edge uv is . The edge irregularity strength of G, denoted by es(G), is the minimum k such that  has an edge irregular k-labeling. This labeling was introduced by Ahmad, Al-Mushayt, and Bacˇa in 2014.  An (n,k)-firecracker is a graph obtained by the concatenation of n k-stars by linking one leaf from each. In this paper, we determine the edge irregularity strength of fireworks graphs F2,m.
Omalizumab and allergen immunotherapy for respiratory allergies
Authors: De Filippo Maria , Votto Martina , Caminiti Lucia , Carella Francesco , De Castro Giovanna , Landi Massimo , Olcese Roberta , Panasiti Ilenia , Vernich Mario , Barberi Salvatore , Ciprandi Giorgio , Marseglia Gian Luigi
Published: November 2022

Although currently approved to treat severe asthma and chronic spontaneous urticaria, omalizumab has also been an effective and safe add-on treatment for other allergic diseases. Namely, omalizumab has been proposed to be used as add-on therapy in patients with allergic rhinitis and asthma and undergoing specific allergen immunotherapy (AIT). AIT is the only treatment that modifies the natural history of IgE-mediated diseases. This brief review summarizes the available evidence and controversies on the efficacy and safety of omalizumab combined with specific AIT.
Vitamin D deficiency in children and adolescents with food allergy
Authors: Pereira Andressa , Mendonça Raquel , Fonseca Fernando , Mallozi Márcia , Sarni Roseli
Published: November 2022

Our objective was to describe the serum vitamin D concentrations of children and adolescents with food allergy (FA) and to verify the association between the number of food allergens involved, length of sun exposure, and nutritional status. Through a cross-sectional study, 79 patients with FA, from ages 2 to 15 years, were assessed and followed up in a reference out-patient clinic, in Sao Paulo, Brazil. Clinical and biochemical data were collected for analysis of 25(OH)D, calcium, phosphorus, phosphatase, parathyroid hormone (PTH), and high-sensitivity C-reactive protein (hs-CRP). The cut-off point used for vitamin D deficiency was 25(OH)D ≤ 20 ng/mL. Vitamin D deficiency was detected in 45.6% of patients with a median age of 6.9 years (Interquartile range [IQR] 4.7; 10.2). The median serum 25(OH)D concentration was 21.1 ng/ mL (IQR 17.8; 26.0). Multivariate linear regression was performed considering serum vitamin D level as a dependent variable. Allergy to multiple foods (inverse) and length of sun exposure (direct), but not nutritional status, were independently associated with serum 25(OH)D levels (P = 0.034 and P = 0.014, respectively). Patients with cow’s milk allergy also showed lower vitamin D concentrations in comparison with other FA (19.1 ng/mL [IQR 16.6; 24.4] vs 22.2 ng/mL [IQR 18.1; 27.1] [P = 0.056]). Vitamin D deficiency affected about half of individuals with FA. Multiple food allergy was associated with lower vitamin D concentrations, reinforcing the importance of monitoring vitamin D status in patients with FA.
Morroniside alleviates lipopolysaccharide-induced inflammatory and oxidative stress in inflammatory bowel disease by inhibiting NLRP3 and NF-κB signaling pathways
Authors: Zhang Shifen , Qiaohua Lai  , Liming Liu  , Yajie Yang  , Juan Wang
Published: November 2022

Objective: To investigate the effects of morroniside on inflammatory and oxidative stress in lipopolysaccharide (LPS)-induced inflammatory bowel disease (IBD) cell model.
Methods: NCM460 cells were treated with 2-, 5-, or 10-μg/mL LPS for 24 h to develop an IBD cell model. MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) colorimet-ric assay was performed to uncover the role of morroniside on the viability of LPS-treated NCM460 cells. Flow cytometry and immunoblot assays were performed to confirm the effects of morroniside on the apoptosis of LPS-treated NCM460 cells. Quantitative polymerase chain reaction and enzyme-linked-immunosorbent serologic assays were performed to confirm the effects of morroniside on inflammatory and oxidative stress by measuring the levels of tumor necrosis factor-α, interleukin-1β, IL-6, superoxide dismutase, malondialdehyde, total antioxi-dant capacity, and myeloperoxidase. In addition, immunoblot and immunofluorescence assays were performed to detect the effects of morroniside on NLRP3 and NF-κB pathways.
Results: Monosine attenuated LPS-induced injury of NCM460 cells. Monosine reduced LPS-induced inflammation in NCM460 cells. In addition, morroniside reduced LPS-induced oxidative stress in NCM460 cells. Mechanically, morroniside suppressed NLRP3 and NF-κB pathways, and alleviated LPS-induced inflammatory and oxidative stress in IBD.
Conclusion: Morroniside could serve as a promising drug for treating IBD.
A new classification option for NSAID hypersensitivity
Authors: Özdemir Ebru , Damadoğlu Ebru , Karakaya Gül , Kalyoncu A. Fuat
Published: November 2022

Background: The European Network for Drug Allergy (ENDA) proposed a consensus document for hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) in 2011. A subgroup of patients with NSAIDs-exacerbated respiratory disease (NERD) develop urticaria/ angioedema type reactions in response to NSAIDs. The Kalyoncu classification might be a novel option to classify patients with NSAID hypersensitivity (NH). In this study, we compare the ENDA and the Kalyoncu classifications.
Methods: This study enrolled a total of 196 patients. NH reaction types were categorized as asthma, rhinitis, urticaria/angioedema and anaphylaxis. Based on the reaction history and oral provocation test findings, patients were grouped according to ENDA and Kalyoncu classifications.
Results: The mean age of the 196 patients was 40.32±13.28 years, and 130 (66.3%) of them were female. Under the ENDA and Kalyoncu classifications, the most common NH subgroups were NERD (32%), and isolated NH (34.2%), the least prevalent NH subgroups were single NSAID-induced delayed reactions (SNIDR) (1.5%), and pseudo Samter’s syndrome (11.7%).
Conclusions: Our research revealed that the Kalyoncu classification is more descriptive of patients with NERD exhibiting urticaria/angioedema-type reactions. It also provides future risk assessment for development of NERD. For controversial cases, the Kalyoncu classification can be utilized as a new complimentary option alone or in conjunction with ENDA classification.
Främmandegöring i samtida antropocen - om konstens metoder i skolan
Authors: Marklund Frida
Published: November 2022

Inom forskning som undersöker utbildning för hållbar utveckling efterfrågas kritiska perspektiv, liksom ett problematiserande av utbildningens grundantaganden och utgångspunkter. Utifrån detta syftar artikeln till att teoretiskt undersöka hur främmandegöring, ett konstnärligt grepp för att fördröja varseblivelsen, kan användas som metod för att erbjuda möjlighet till problematisering och kritisk granskning i undervisning. De frågor artikeln söker svar på är: På vilket vis kan främmandegöring förstås som en pedagogisk metod? Hur kan främmandegöring användas som ett kritiskt perspektiv i utbildning? Artikeln utgår från bildämnet och dess konstnärliga metoder. Ett skolprojekt från en empiriskt grundad forskningsstudie i grundskolan används som exempel för att pröva begreppets relevans och bäring i utbildningssammanhang. Det framkommer att främmandegöring kan användas som metod både i möten av verk och som alternativa undervisningsformer. Främmandegöring kan även vara ett verktyg för att kritiskt granska olika fenomen, men det kräver en medveten och genomtänkt iscensättning av undervisningen från lärarens sida.
Starting from Kerbung and Ending in Pesantren: The Analysis of the Track Record of the Emergence of Pesantren in Lombok
Authors: Murdianto
Published: November 2022

The people of Lombok have recognized the term of Kerbung prior than Pesantren (Islamic Boarding School). Kerbung was the Islamic boarding school (hereafter pesantren) of Lombok’s Society. However, both Kerbung and Pesantren are Islamic educational institutions rooted in the history and culture of Indonesia. The track record of the emergence of Pesantren in Lombok was associated with the revival of Islam in the late 19th century. It was marked by the growth of recitation centers, as can be found in Pagutan, Kediri, Batubangka Sakra, Praya, Sesela, Sekarbela and Tanjung (East Lombok). Besides, more than 2000 intellectual works of Lombok's Muslims were also found at that time. Some of these manuscripts were used as references by the tuan guru for their students. This research is field research with a qualitative paradigm. This study found that the track record of the emergence of pesantren in Lombok was an integration of the Islamic educational system in Lombok, Java and the Middle East. However, the emergence of pesantren in Lombok was inseparable from the founding fathers of the pesantren itself.