bluuebunny/crossref_metadata_2025 huggingface dataset:
Accuracy of core biopsy image-guided post-neoadjuvant chemotherapy breast to predict pathologic complete response
Authors: Krivorotko P. V. , Mortada V. V. , Pesotskiy R. S. , Artemyeva A. S. , Emelyanov A. S. , Ereshchenko S. S. , Dashyan G. A. , Amirov N. S. , Tabagua T. T. , Gigolaeva L. P. , Komyakhov A. V. , Nikolaev K. S. , Mortada M. M. , Zernov K. Yu. , Zhiltsova E. K. , Smirnova V. O. , Bondarchuk Ya. I. , Enaldieva D. A. , Novikov S. N. , Busko E. A. , Chernaya A. V. , Krzhivitskiy P. I. , Paltuev R. M. , Semiglazova T. Yu. , Semiglazov V. F. , Belyaev A. M.
Published: December 2022

Background. Achieving a pathologic complete response (pCR) after neoadjuvant systemic therapy (NST) is a predictive factor for improving disease free and overall survival. In triple negative (TN) and HER2-positive breast cancer (BC), the pCR rate exceeds 60 %. Patients with TN and HER2-positive BC who demonstrate an excellent response to NST are like­ly ideal candidates for downsizing surgery. The condition for reducing the volume of surgical intervention is a reliable determination of pathologic complete response using instrumental imaging and biopsy methods.

Aim. To further assess the accuracy of post-NST image-guided biopsy to predict pCR.

Materials and methods. Sixty one patients with T1-3N0-3 triple negative or HER2-positive BC receiving NST in the Department of Breast Tumors of the NMRC of Oncology named after N.N. Petrov in the period from 2017 to 2019 were enrolled in this single-center retrospective trial. Patients underwent ultrasound-guided core-biopsy of the initial breast tumor region before surgery. Findings were compared with findings on pathologic evaluation of surgical specimens to determine the performance of biopsy in predicting pCR after NST.

Results. After neoadjuvant systemic therapy, clinical partial response (cPR) was diagnosed in 47 (77 %) patients, clinical complete response (cCR) in 14 (23 %) patients. pCR in the core-biopsy tissue and surgical material was achieved in 46 (75.4 %) and 37 (60.7 %), respectively. Performance of image-guided core-biopsy: sensitivity 100 % (95 % confldence interval (CI) 90.51-100), specificity 62.5 % (95 % CI 40.59-81.20), false-negative rate (FNR) 0 %, positive-pre­dictive value (PPV) 75.00 % (95 % CI 59.46-85.99), negative predictive value (NPV) 100.00 %.

Conclusion. This retrospective trial showed that ultrasound-guided core biopsies are accurate enough to identify breast pCR in patients with triple-negative or HER2-positive BC with good response after NST (FNR 0 %). Based on these results, a prospective clinical trial has commenced in which breast surgery is omitted in patients with a breast pCR after NST according to image-guided biopsy.
MicroRNA-dependent mechanisms of taxane resistance in breast cancer
Authors: Apollonova V. S. , Sidina E. I. , Tkachenko E. V. , Malek A. V.
Published: December 2022

Breast cancer (BC) has a leading position in the statistics of oncological morbidity and mortality among women. Taxan-based polychemotherapy regimens are an essential component of the complex therapy of the BC. However, currently used algorithms of taxan-based regimens application do not always provide with desire effect. It indicates the need to identify new prognostic markers and to develop new approaches to modify response of BC cells to standard therapeutic regimens. MicroRNAs, small RNA molecules regulating protein synthesis, are considered as promising markers and potential modulators of the BC cells sensitivity to taxanes.

The review includes a brief summary of the molecular mechanisms of action of the taxanes and the mechanism BC resistance to the process of microtubules depolymerization, provides with analysis of recent experimental and observational studies of the role of microRNAs in control of these mechanisms, and evaluates prospects for the development of new approaches to predict and to improve the cytostatic effects of taxanes through the analysis and modification of cellular microRNAs.
Significance and possible causes of hormone receptor expression loss in metastatic breast cancer. Phenotypic evolution of luminal BRCA1-associated breast cancer to triple negative subtype in lung metastasis and PARP inhibition strategy in early-line therapy
Authors: Stukan A. I. , Khachmamuk Z. K. , Antipova V. V. , Dzagashtokova A. V.
Published: December 2022

Current clinical recommendations indicate the need for a biopsy of a metastatic focus in metastatic breast cancer (BC), but the optimal frequency of additional molecular analysis remains unclear. The discordance of hormonal receptors (HR) between the primary tumor and metastatic foci has prognostic significance, while the transition from HR-positive BC to a triple negative phenotype is associated with a worse clinical prognosis. Acquisition of HR expression in primary triple negative BC is more favorable due to the wide range of options for HR-positive BC treatment. Over the past few years, PARP inhibitors have become an important therapeutic option for the treatment of various tumor types, including BC and luminal surrogate subtypes. However, some questions still remain unresolved, the most important of which are: what is the optimal sequence of the use of CDK4 / 6 inhibitors as part of combined hormone therapy and PARP inhibitors in luminal types of BRCA-associated BC and how effective is the strategy of PARP inhibition after the use of combined hormone therapy with CDK4 / 6 inhibitors? It is obvious that the answers to the questions can be partially obtained by performing a biopsy of the most clinically significant metastatic focus and selecting therapy according to the phenotypic surrogate subtype. A clinical case of the phenotypic evolution of HR-positive BRCA1-associated BC into a triple negative phenotype during metastasis to the lungs and the luminal phenotype of tumor metastasis in soft tissues is presented. Biopsy of the most clinically significant metastatic lesion in the lungs in this case changed the strategy of early-line therapy for estrogen-receptor-positive disease, when in the absence of a biopsy, a combined hormone therapy regimen with CDK4 / 6 inhibitors could be applied. At the same time, the strategy of using PARP inhibitor talazoparib, which has shown efficacy in all surrogate subtypes, should certainly be prescribed in the early line of therapy for BRCA-associated disease with loss of estrogen receptor expression. Despite the luminal phenotype of metastasis in the soft tissues of the back and the unknown status of bone metastases, the drug demonstrates efficacy in these cases as well. It should be noted that partial response according on RECIST 1.1 months with an improvement in the quality of life and the disappearance of pain syndrome was evaluated after 10 weeks of treatment. The response duration was an unprecedented 10 months.
Malignant transformation of endometrial hyperplastic processes: immunohistochemical features
Authors: Sobivchak M. S. , Protasova A. E. , Raskin G. A. , Mukhina M. S. , Kaurtseva A. S.
Published: December 2022

Background. Endometrial hyperplasia is one of the most common pathologies of the female reproductive system. There is a high risk of transformation of an atypical form of endometrial hyperplasia into endometrial cancer, which takes a leading position in oncogynecological morbidity. Immunohistochemical markers can become predictors of endometrial malignancy, their role is currently being actively studied.

Aim. Search for molecular predictors of malignant transformation of endometrial hyperplasia.

Materials and methods. Histological and immunohistochemical studies were performed in 107 patients with diagnoses of endometrial hyperplasia without atypia (EH), endometrial atypical hyperplasia (EIN), endometrioid adenocarcinoma (EC). The tumor receptor status, MSI, expression of ARID1A, PTEN, β-catenin, PAX2, proliferation index (Ki-67) were determined by the immunohistochemical method according to the standard protocol.

Results. Loss of PAX2 expression was most common in precancerous and malignant endometrial cells. Loss of PAX2 expression was found in 89 % of cases in the EIN samples, in 86 % of cases in the EC samples and only in 2 cases of EH. Loss of PTEN expression was less common: with an equal proportion in 67 % of the samples of EIN and EC, while practically not occurring in women with benign GE. MSI was detected in 36 % of endometrial cancer samples. There was a deficiency in the DNA repair system in 1 case of EIN. Loss of ARID1A expression was detected in endometrial cancer with a frequency of 33 %. This gene functioned normally in all cases of EIN and EH. The expression of β-catenin was more pronounced in EC than in cases of EH. The Ki-67 proliferation index was statistically higher in the EC group than in EH and EIN.

Conclusion. Evaluation of morphological data and expression of the panel of markers PAX2, PTEN, ARID1A, β-catenin, Ki-67 index, PMS2 and MLH1 will improve diagnostic search in case of suspected malignancy of endometrial hyperplasia.
FROM THE LAST MILE TO THE FIRST: АN ANALYSIS OF ORGANIZATIONAL PROBLEMS ON THE EXAMPLE OF THE PROCUREMENT PROCESS
Authors: Pleschenko V. I.
Published: December 2022

Many specialists know the problem of the “last mile”, which consists in a noticeable increase in the difficulties and costs that arise at the final stages of a process in economic systems. In some cases, insufficient efficiency and effectiveness of processes has background that arises at the initial stage of the process, or are generally beyond it. This problem of the “first mile” is considered in this article on the example of the organization of procurement activities of industrial companies.
Cobamide Distribution in Winogradsky Columns Supplemented with Halogenated Environmental Contaminants
Authors:   , McQueen Lilly Marie , Beld Joris , Ma Amy T.
Published: December 2022

Halogenated contaminants have been accumulating in our environment without an efficient method of remediation since their industrial use began in the 20th century. Recently, microbes that utilize cobamide-dependent reductive dehalogenases and iron-dependent reductive defluorination to degrade these compounds have been identified. Cobamides like cobalamin and pseudocobalamin are necessary cofactors for several enzymes, including a superfamily of reductive dehalogenases, and it has also been speculated that cobamides play a role in reductive defluorination. Cobamides are biosynthesized by a relatively small subset of bacteria but can be crossfed between species. To interrogate the presence and distribution of cobamides in a fresh-water environment, we determined the distribution of cobamides in a 1L Winogradsky column using liquid chromatography mass spectrometry (LCMS). Pseudocobalamin was found in the biofilm and top layers of the column and cobalamin was found throughout. A novel method of Winogradsky column construction was developed in which sediment and water from 1-liter columns was used to construct 150 mL 'miniature' Winogradsky columns, allowing for replicated testing of several experimental conditions. These columns were supplemented with trichloroethene (TCE), perfluorooctanoic acid (PFOA), and a cobamide precursor to enrich for cobamide-utilizing halogenated compound degraders in a complex microbial community. Cobamide analysis through mass spectrometry showed a variety of effects of these contaminants on cobamide identity and concentration. This experimental set up gives us a new way to study interspecies community metabolism in complex environmental samples, with the end goal of identifying microbial degraders of environmental contaminants.
Future of Oral Medicine and Radiology specialist in India
Authors: Bahal Megha , Choudhary Aditya , Roul Ayesha , Sapra Ruby
Published: December 2022

An oral medicine doctor is trained to diagnose and manage patients with disorders of the orofacial region, essentially as a "physician of the mouth." An oral medicine doctor has received additional specialized training and experience in the diagnosis and management of oral mucosal abnormalities (growths, ulcers, infection, allergies, immune-mediated and autoimmune disorders, cancers), salivary gland disorders, temporomandibular disorders (e.g.: problems with the TMJ) and facial pain (due to musculoskeletal or neurologic conditions), taste and smell disorders; and recognition of the oral manifestations of systemic and infectious diseases. The life of an oral medicine and radiology specialist is till date not considered an utmost branch. In the scenario when it is the upcoming sector of dentistry, the future prospects of this speciality is the hot topic of discussion.
Mental foramen of mandible in South Kerala population - A digital radiographic study
Authors: Mahadoon Nivia , Sivakumar R , Padmakumar S. K , Rajasekharan Asish , Binu Jeffy , Anu Andrews
Published: December 2022

To assess whether there is sexual dimorphism in the location of mental foramen from base of mandible in South Kerala population.

A two-year retrospective study was conducted in 200 subjects [100 males and 100 females] using digital radiographs. The location of mental foramen mandible was assessed from digital orthopantomogram. The vertical distance was measured from the superior border of the mental foramen to the lower border of the mandible and the inferior border of the mental foramen to the lower border of the mandible. The obtained data statistically analyzed using SPSS software version 20. Descriptive statistics was analyzed. Independent t-test was done to determine the association between gender and different parameters. The level of significance set at p ≤ 0.05.

The average value of the distance of lower border of mandible from the superior and inferior border of mental foramen is found to be significantly higher in males than females.

The study revealed that there is sexual dimorphism in the location of mental foramen in South Kerala population.
Prediction of osteoporosis in men and women through orthopantomograph
Authors: Patel Priyanka Bipin , Dave Riya Divyakant , Patel Twinkal Shileshbhai , Patel Purv , Dudhia Bhavin , Bhatia Parul
Published: December 2022

Osteoporosis is a systemic disease characterized by low bone mineral density, deterioration of bone structure and increased bone fragility most commonly seen in females of old age as a result of lack of estrogen. The mandibular cortical index, observed on panoramic radiograph, is useful for the screening of osteoporosis.

The aim of the study is to study and analyze thickness of mandibular cortical bone on orthopantomography as a representative for the preliminary diagnosis of osteoporosis.

The study was conducted on 100 subjects orthopantomographs which included both males and females of all ages. Patients with prior systemic diseases were not included.

There were 50% males and 50% females in the age group of 21-90 with 43% in group 1 patients with all teeth, 57% in group 2 patients with few or no teeth. Group 1 had 60.5% males and 39.5% females, Group 2 had 42.1% males and 57.9% females. C1 had 43%, C2 42% and C3 15%. C1 had 52% males, 42% females, C2 had 48% males, 36% females, C3 had 30% females, 0% males.

There is relevant relation between age, gender and osteoporosis. With increased age there is decreased oral health seen in both males and females of middle aged. Due to decreased levels of estrogen in females they are more likely to develop osteoporosis. Use of radio morphometric indices on OPG can predict osteoporosis. There are high chances of osteoporosis in females than males.
Dual odontogenic tumors unicystic ameloblastoma and compound odontoma in a 24 year old male: A case report
Authors: Wadhawan Richa , Dua Piyush , Krishna Gopal , Devi Laishram Memory , Ali Naseef , Singh Anchal
Published: December 2022

Unicystic ameloblastomas is one of imperturbable jaw tumor. It is a quirky and unique cystic variant of ameloblastoma with clinical and radiological features having kinship with odontogenic cysts of developmental and inflammatory origin and has a favorable prognosis rate. This paper presents a case of a unicystic ameloblastoma in a 24-year-old male in his right angle and ramus of mandible region along with compound odontome in left posterior maxilla.
Rola steroidów płciowych w chorobach neurodegeneracyjnych
Authors: Sadowska Aleksandra , Grzesiak Małgorzata
Published: December 2022

Wraz ze wzrostem średniej długości życia i starzeniem się ludzkiej populacji, zwiększa się odsetek osób cierpiących na choroby neurodegeneracyjne (NDs). W przypadku choroby Alzheimera (AD), choroby Parkinsona (PD) i stwardnienia zanikowego bocznego (ALS), zaobserwowano wyraźną dysproporcję w zachorowalności w zależności od płci. Uważa się, że może to mieć związek z wpływem steroidów płciowych na ryzyko wystąpienia tych chorób. Dane epidemiologiczne pokazują, że na AD częściej cierpią kobiety, natomiast PD i ALS są bardziej rozpowszechnione u mężczyzn. Liczne badania wskazują na neuroprotekcyjne działanie estrogenów i potwierdzają, że czynniki redukujące ich poziom zwiększają ryzyko zachorowania na NDs. Odwrotne efekty zaobserwowano dla androgenów, chociaż dowiedziono także korzystnego wpływu tych hormonów. Zrozumienie potencjalnej roli steroidów płciowych i ich receptorów w patogenezie i przebiegu NDs może przyczynić się do lepszego poznania molekularnych mechanizmów leżących u podłoża tych schorzeń, a tym samym do opracowania skuteczniejszych sposobów prewencji i leczenia.
Pratique de l’orpaillage ET dégradation des conditions de vie des populations rurales: étude de CAS dans la sous-préfecture de Tienkoikro (Côte d’Ivoire).
Authors: Ernest KOFFI Fêtê , Adolphe KOUADIO Kouassi Kan , Moussa SANGARE
Published: December 2022

Under the combined effect of natural and social factors, in particular climate change, land disputes and the impoverishment of populations, we are witnessing a proliferation of gold panning sites in most villages in central and northern Côte d’Ivoire. For some, gold panning is a palliative for the lack of agricultural land and would reduce land conflicts. For others, this practice would be a factor of quick enrichment, less painful than agriculture. Unfortunately, this practice is not without effect on agriculture, waterways and socio-cultural values. All the actions of sensitization and repression did not affect the determination of the artisanal gold miners; on the contrary, clandestine gold panning is developing more with increasingly sophisticated tools.
This study took place in the sub-prefecture of Tienkoikro. Data collection was done through interviews and documentation. The objective is to show the effects of the practice of gold panning on the living conditions of peasant populations.
Avaliação microbiológica de iogurte de leite de búfala produzido a partir da fermentação assistida por ultrassom
Authors: Pacheco Flaviana Coelho , Teixeira Eliane de Fátima , Pacheco Ana Flávia Coelho , Justino Heloisa de Fátima Mendes , Cunha Jeferson Silva , Santos Fabio Ribeiro dos , Paiva Paulo Henrique Costa , Leite Júnior Bruno Ricardo de Castro
Published: December 2022

O iogurte é um alimento lácteo de grande importância para a alimentação humana em virtude de suas propriedades funcionais, além de ser muito popular em todo o mundo. Tradicionalmente, no Brasil esse produto é elaborado a partir do leite bovino. Entretanto, nos últimos anos tem crescido a produção de iogurte fabricado a partir do leite de outros mamíferos, assim como tem intensificado os estudos acerca da aplicação de tecnologias não convencionais na tecnologia de alimentos, como o ultrassom. Neste estudo, foram produzidas diferentes amostras de iogurte de leite de búfala por meio da aplicação de ultrassom, visando reduzir o tempo de fermentação, assim como melhorar as características desejáveis do produto final. Desta forma, pensando nas propriedades higiênico sanitárias do iogurte e consequente segurança do alimento, este trabalho objetivou avaliar a qualidade microbiológica do produto. Todas as amostras apresentaram dentro da legislação para bolores e leveduras, mesófilos e piscrotróficos. Assim, ressalta-se a importância da aplicação das boas práticas de fabricação de modo a garantir a qualidade e segurança dos alimentos.
Caracterização de filme de acetato de celulose incorporado com nanocristais de celulose e aroma de salada de fruta
Authors: Gomes Bárbara Teixeira , Souza Amanda Lélis de , Oliveira Taila Veloso de , Soares Nilda de Fatima Ferreira
Published: December 2022

O acetato de celulose (AC) é um polímero biodegradável hidrofóbico, derivado da celulose. Os biopolímeros geralmente apresentam desempenhos inferiores em relação aos polímeros derivados de petróleo. Dessa forma nanocristais de celulose (CNC) têm sido usados como reforço, para melhorar as suas propriedades. Atualmente as embalagens ativas com sistemas emissores, que incorporam substâncias a embalagem e estes são transferidos gradativamente para o alimento, como por exemplo o aromatizante, vem sendo solicitados e estudados. Desta forma o objetivo do trabalho foi caracterizar um filme de AC com CNC e aroma de salada de frutas (ASF) em relação à espessura, cor, transmitância e opacidade, para se estabelecer os requisitos necessários para esse filme, visando uma futura aplicação. Para avaliar os dados foi feita a análise de variância, seguida do teste t-Student (p<0.01). Os resultados da espessura mostram que a técnica e as condições utilizadas proporcionaram a obtenção de filmes finos. A adição de CNC e aroma não modicou a espessura quando comparado ao filme controle, mas influenciaram a opacidade do filme, levando a um incremento nessa característica e proporcionou uma maior barreira à transmissão de luz. O parâmetro de cor L* indica a obtenção de filmes claros. Os valores de a* negativos indica uma coloração mais próxima da região do verde e de b* positivos mostram uma tendência para a cor amarela. O filme de AC com CNC e ASF se mostrou favorável para uma futura aplicação em salada de frutas.
Mineração de dados em tweets para análise do consumo de lácteos no Brasil
Authors: Nogueira Thallys da Silva , Monteiro Anna Letícia Franco , Silva Darlan Henrique da Costa , Siqueira Kennya Beatriz , Goliatt Priscila Vanessa Zabala Capriles
Published: December 2022

A pandemia da COVID-19 causou diversos impactos na rotina dos brasileiros e a alimentação é um deles. O foco deste trabalho foi analisar o consumo de produtos lácteos no Brasil nos últimos tempos, empregando dados da rede social Twitter, com a ferramenta Observatório do Consumidor. Com o objetivo de responder às perguntas “Quais são os derivados lácteos mais consumidos no Brasil?” e “Como foi este consumo ao longo do tempo?”, utilizou-se técnicas de processamento de linguagem natural nos dados para identificar os verbos referentes ao consumo e suas respectivas frequências ao longo do tempo. Foi observado que sorvete, leite condensado, queijos, doce de leite e leite foram os cinco produtos lácteos que obtiveram maior número de menções a verbos que remetem ao consumo, caracterizando-os como os produtos mais consumidos no período analisado. Entretanto, foi observado que o consumo de lácteos vem diminuindo desde 2020. Estes resultados mostram que é possível analisar de forma rápida, dinâmica e barata, o consumo de alimentos por meio das redes sociais.
Kamaboko, um produto japonês: revisão de literatura
Authors: Pereira Thaís Regina de Castro , Cipriano Lévison da Costa , Azevedo Estella Francisco de , Farias Camile de Oliveira Luz , Mano Sergio Borges , Esmerino Erick Almeida , Marsico Eliane Teixeira
Published: December 2022

Este levantamento buscou realizar uma revisão sobre o kamaboko, utilizando artigos da base de dados do sistema de periódicos CAPES, publicados entre os anos de 2017 e 2022, sendo abordado pontos importantes como metodologia de elaboração, ingredientes utilizados na sua preparação e produtos correlatos ao kamaboko. O kamaboko é um produto originário do Japão e tem comoprincipal ingrediente o sur imi, alimento feito à base de carne de peixes. A textura deste produto é fator determinante para sua qualidade e pode ser influenciada pela temperatura de cozimento e pela qualidade dos ingredientes utilizados. O cozimento preconizado é feito em duas etapas, inicialmente próximo de 40° C, sendo iniciada a formação do gel e posteriormente em temperaturas entre 70 °C e 90 °C, que permitem o aumento de sua elasticidade. Entretanto, em temperaturas entre 50 °C e 70 °C pode ser gerado um produto mais macio e de textura mole, comcaracterísticas sensoriais inadequadas. Os principais ingredientes utilizados em sua preparação são o sal, açucar e amido, cada um com sua importância na formulação final. A partir do surimi também podem ser produzidos outros produtos correlatos como o “hanpen” e o “tsumike”. Portanto, por possuir características nutricionais desejáveis, como alto teor proteico, baixo teor de gordura e poucas calorias, o kamaboko pode ser considerado um produto nutritivo e saudável.
Rito y economía en Cajamarquilla: investigaciones arqueológicas en el Conjunto Arquitectónico Julio C. Tello
Authors: Segura Llanos Rafael Antonio
Published: December 2022

Este libro, originalmente presentado como una tesis de grado, trata sobre uno de los sectores de sitio monumental de Cajamarquilla, valle del Rímac, donde el autor excavara en el marco del Proyecto Arqueológico Cajamarquilla. En el se sostiene que, al menos en el Conjunto Julio C. Tello y durante etapas específicas, los eventos de carácter ritual y simbólico estuvieron inscritos en un episodio mayor de manejo de mano de obra y consecuente ampliación física de la arquitectura. Tales eventos se habrían efectuado alrededor del año 600 d.c., cuando predomina una ocupación Lima tardío en Cajamarquilla y en gran parte del valle del Rímac.
Developing a scale of scientific sense for students at a private university.
Authors: Abufoudeh Basel , Mahameed Mohammed
Published: December 2022

The study indicates the importance of providing students with the scientific sense and its concomitant development. It aims to develop a scale of scientific sense for students at a Private University. This study is the first to develop a scale of scientific sense for students. The sample included (395) students enrolled during the Summer Semester 2019/2020. The results showed high psychometric properties of the scales of scientific sense. The indicators of conformity within the accepted standard confirm the construction validity of the scale of scientific sense. The scale of scientific sense in its cognitive and emotional aspects greatly contributes to the acquisition of scientific knowledge, life skills and the achievement of educational goals in higher education institutions. The study recommended using the final vision of the scale of scientific sense, and utilizing the scale to verify the scientific sense (Cognitive, Emotional) of the students.
Keywords: development; scale; scientific sense; cognitive; emotional; exploratory factor analysis; confirmatory factor analysis.
Key Considerations: Cross-Border Dynamics between Uganda and South Sudan in the Context of the Outbreak of Ebola, 2022
Authors: Moro Leben , Robinson Alice
Published: December 2022

This brief summarises key considerations concerning cross-border dynamics between South Sudan and Uganda in the context of the 2022 outbreak of Ebola in Uganda, and the risk of the spread of the virus into South Sudan. It is one of four briefs exploring cross-border dynamics in the context of the outbreak, alongside Kenya, Rwanda and Tanzania. The outbreak is of the Sudan strain of Ebola (Sudan Virus Disease, SVD). SVD is used in this paper to refer to the current outbreak in East Africa, whereas outbreaks of Zaire Ebolavirus disease or general references to Ebola are referred to as EVD. The outbreak of SVD began in Mubende, Uganda, on 19 September 2022. At the time of writing (25 November), there had been 141 confirmed cases and 55 deaths, including seven health workers. Infections had been confirmed in nine districts in Uganda, including in Kampala – a major transport hub. Vaccines used in previous Ebola outbreaks are effective against the Zaire strain of Ebola, and vaccines that could work against the Sudan strain remain under investigation. As of November 2022, there have been no confirmed cases of SVD imported into South Sudan, although several alerts have been investigated. However, the fear that travellers from Uganda might bring the disease into South Sudan has spurred preparations by government institutions and partner organisations, building on the experiences acquired during past outbreaks, particularly Ebola and COVID-19. An EVD High Level Taskforce has been formed, chaired by the Minister for Cabinet Affairs and co-chaired by the Minister of Health. The South Sudan Ministry of Health (MoH) has activated the Public Health Emergency Operation Centre (PHEOC) and Incident Management System (IMS). A national EVD Readiness Plan has been developed and endorsed by the government. A free hotline (number 6666) is in place, which can be used either to report suspected cases or for information on Ebola. Training of staff at border entry points has started. This brief is based on a rapid review of published and grey literature, and informal discussions with the South Sudan Red Cross, IOM, academics from University of Juba, and the PHEOC. It was requested by the Collective Service and was written by Leben Nelson Moro (University of Juba) and Alice Robinson (London School of Economics). It was reviewed by colleagues at the University of Bath, the PHEOC, Internews, Anthrologica, the Institute of Development Studies and the Collective Service. The brief is the responsibility of the Social Science in Humanitarian Action Platform (SSHAP).
Prostatın benign, prekürsör ve malign epitelyal proliferasyonlarında ERG ile PTEN ekspresyonlarının araştırılması ve bulguların klinikopatolojik korelasyonu
Authors: SARSIK KUMBARACI Banu , KANAT Emre , AYKUTLU Umut , KIZILAY Fuat , ŞEN Sait
Published: December 2022

Amaç: Prostat kanseri farklı klinik gidişata ve geniş bir tedavi yelpazesine sahip, klinik ve moleküler olarak oldukça heterojen bir kanser türüdür. Özellikle “prostatik intraepitelyal neoplazi” (PİN), “atipik intraduktal proliferasyon” (AİP) ve “intraduktal karsinom” (İDK) benzer morfolojik özelliklere sahip olması açısından ayırıcı tanı zorluğu yaratan tanılar olup, hasta tedavi ve takibi de farklı olan antitelerdir. Çalışmamızda bu lezyonlarda ERG ve PTEN ekspresyon düzeylerini belirlemeyi ve bu biyobelirteçlerin prognostik ve diagnostik değerini araştırmayı amaçladık. Gereç ve Yöntem: EÜTF Tıbbi Patoloji Anabilim Dalında 2011-2012 yılında radikal prostatektomi veya iğne biyopsi materyallerinde “Adenokarsinom” tanısı almış 87 olgu çalışmaya alındı. Histopatolojik olarak AİP, İDK ve PİN içeren alanlar belirlendi. immunohistokimyasal olarak bu alanlarda ERG ve PTEN ekspresyonları değerlendirildi.Bulgular: Olguların 6’sında İDK, 29’unda AİP ve 52’sinde PİN belirlendi. İDK AİP, DG 3 ve üstünde olan tümörlerde daha fazla görüldü. İDK ve AİP in eşlik ettiği prostat karsinomlarının sağ kalım süresi daha kısaydı (p=0.043). İDK ve AİP içeren tümörlerde ERG ve PTEN durumu invaziv komponentle uyum içindeydi. Ayrıca tüm İDK alanlarında ERG pozitifti. PTEN ile heterojen boyanma görülmüş olup, PTEN’in invaziv karsinom ve İDK alanlarında negatifliği daha fazlaydı (p=0,63). ERG pozitifliği ve PTEN negatifliği istatistiksel olarak anlamlı olmamakla birlikte AİP tanısını desteklediği dikkati çekti.Sonuç: Özellikle ayırıcı tanı sorunu yaratan intraduktal lezyonlarda ERG pozitifliği ve PTEN negatifliği klinik öneme sahip prostat karsinomuna eşlik edebileceği için özellikle biyopsilerde gözardı edilmemeli ve hasta tedavi ile takibi buna göre yapılmalıdır.
Analysis Factors Affecting Employee Performance of BKD East Java When Work from Home
Authors: Meirana Ayu
Published: December 2022

Covid-19 pandemic has had a tremendous impact on all aspects of people's lives around the world, including Indonesia. Therefore, the government issued a policy towards the civil servant work system to become Work from Home (WFH). Human resources in government agencies, especially in the Regional Civil Service Agency (BKD) of the East Java, are required to carry out their duties and obligations maximally so that performance increases, even though they do not work from the office. The sample of this research is 56 employees of BKD in East Java. The technique of collecting data through distributing questionnaires. The analysis tool used is Partial Least Square (PLS) analysis. This study concludes that the use of information technology has a significant effect on emotional intelligence, job stress, and employee performance. Emotional intelligence has a significant effect on employee performance. Meanwhile, job stress has no significant effect on employee performance.
Tokopedia X Blackpink Advertising Discourse Analysis
Authors: Dianitasari Fitri
Published: December 2022

Advertising is an interesting discourse to attract public attention. Advertising itself has undergone changes where lately it has focused on the approach side to products, product symbols, personal, and market segments. Not a few online buying and selling sites use advertisements to promote trademarks, for example Tokopedia. Tokopedia provides a variety of products that are needed. Tokopedia Advertising Discourses are produced to attract consumers to use or buy the products offered. The emergence of popular artists in online store advertisements is a current trend. No need to be surprised if Indonesia uses Kpop artists in marketing their products. This study used a descriptive qualitative method. The data is taken from Tokopedia's e-commerce advertisement in collaboration with Korean girl group Blackpink. The object used in this research is an advertisement from the online shop Tokopedia collaborating with a Korean girl group, namely BLACKPINK with the theme Tokopedia x Blackpink by discussing the discourse structure of Teun A. Van Dijk in 3 aspects, namely superstructure, micro structure, and macro structure. Discourse analysis research on Tokopedia advertisements using Van Dijk Theory shows that the three parts has succesfully appear in Tokopedia advertisements. From the analysis that has been done, it shows that the material owned by Tokopedia ads is complete and the advertisement is able to describe the message that the advertiser wants to convey to the audience which are the benefits and special events.
Knowledge Improvement of Xerosis Cutis through Health Education in the Elderly
Authors: Damayanti  , Astindari  , Indranarum Trisiswati , Mappamasing Hasnikmah , Hadiwidjaja Farsha Naufal , Axelia Presstisa Gifta
Published: December 2022

Background: Xerosis cutis presents in more than 50% of the elderly population and is currently the most common complaint related to a skin condition in the elderly population. However, many of them are still uninformed of this complaint. Education plays an important role in the management of xerosis cutis, such as how to identify and avoid triggering factors and how to break the itch-scratch cycle. Purpose: This study aims to evaluate the level of knowledge on xerosis cutis in the elderly population after receiving health education. Methods: This observational study involved 71 subjects who met the inclusion criteria of being elderly and were willing to participate in this study. The data were collected using questionnaires. The level of knowledge was assessed before and after the health education around xerosis cutis. Result: Eleven (15.49%) male and 60 (84.51%) female subjects participated in this study. There was a significant difference mean scores between the pre-test and post-test after health education (p= <0.001). The means of total scores of the pre-test and post-test were 11.72 ± 1.475 and 12.58 ± 1.662. The questionnaire consisted of  chapters regarding skin changes in the elderly, risk factors for xerosis cutis, and management of xerosis cutis. A significant difference in score between the pre-test and post-test was found in all the chapters (p=0.046, p=0.002, and p=0.006). Conclusion: Following health education, there was an improvement in the elderly's level of knowledge on xerosis cutis.
Pediatric Viral and Bacterial Skin Infection Profile
Authors: Dimawan Rully Setia Agus , Prakoeswa Flora Ramona Sigit , Pramuningtyas Ratih
Published: December 2022

Background: Viral and bacterial skin infection is a common condition amongst children. In developing countries, it is a complex major health problem. However, epidemiological study on viral and bacterial skin infection in the pediatric population is still lacking, especially in Indonesia. Purpose: This study aimed to evaluate bacterial and viral skin infection amongst children and its association with age and sex. Methods: This study used a cross-sectional design with a retrospective approach. We retrieved medical records of pediatric patients admitted to Dr. Harjono S Ponorogo General Public Hospital between 2016 and 2020. Result:  Of the 1,427 collected medical records, we found that the viral infection prevalence was 4.9% (n=70) and 7.5% (n= 107) for bacterial skin infection. Viral infection was most observed amongst subjects in the >12-year age group and 2–12-year for bacterial infection. Infection was more commonly observed amongst boys. Conclusion: The skin infection prevalence in Dr. Harjono S. Ponorogo General Hospital is lower compared to other studies. Skin infection of viral origin was most reported in children aged >12 years and bacterial infection in children aged 2–12. Both skin infections were more commonly observed in boys than girls.
Borderline Lepromatous Leprosy with Severe Erythema Nodosum Leprosum: A Case Report
Authors: Pratama Nevristia , Luh Made Mas Rusyati  , Prima Sanjiwani Saraswati Sudarsa  , IGAA Dwi Karmila  , NLP Ratih Vibriyanti Karna
Published: December 2022

Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae (M. leprae) that primarily infects Schwann cells in the peripheral nerves, leading to nerve damage and the development of disabilities. In 2018, Indonesia was the third country with the most leprosy cases in the world. Erythema nodosum leprosum (ENL), also known as type II leprosy reaction, is a severe immune-mediated complication of multibacillary leprosy. Purpose: To report a case of borderline lepromatous leprosy with severe ENL. Case: A 49-year-old Balinese man presented with multiple tender erythematous skin nodules all over his body, fever, arthralgia, bilateral cervical lymphadenopathy, and sensory loss for the past week. The acid-fast bacilli bacteriological examination showed a positive result. The patient was diagnosed with borderline lepromatous (BL) leprosy with severe ENL and was treated with multibacillary multidrug therapy (MB MDT), methylprednisolone, and other symptomatic medications. After 1 month of treatment, there was an improvement in skin lesions. The MB-MDT treatment was continued and methylprednisolone was planned to be tapered down gradually. Discussion: Approximately 20-50% of all leprosy patients show leprosy reactions in the course of the disease. The goals of treatment for severe ENL are to control inflammation, reduce pain, treat neuritis to prevent nerve dysfunction and contractures, and prevent recurring ENL. The prognosis of leprosy with ENL reactions depends on the severity of the occurring leprosy reaction; early diagnosis and prompt treatment; and patient compliance with treatment. Conclusion: Early diagnosis and treatment are essential to avoid deformities in leprosy patients.
Image Contrast Enhancement in CT SCAN for Determining Cervical Cancer Area
Authors: Ain, S.T., M.Si. Dr. Khusnul , Purwanti Iis , Haris Bambang
Published: December 2022

The quality of the contrast enhancement, which is deemed to be vague in contrast between one region and another, is a problem that many doctors face once identifying their patients with CT scan images. Image correction was used in this study to help doctors gain good CT scan images. In addition to reducing errors in the administering of radiation doses during treatment, accurate images are used to locate and assess the extent of cancer in patients. In this study, a computer application program to improve image contrast was created using the linear regression equation method. In this investigation, the cancer area is still being manually marked by doctors. Additionally, the proportion of the cancer area in the image that the doctor marked from the corrected image is calculated by comparing the ratio of cancer pixels to body pixels. The severity of the cancer is estimated using the proportion of the affected area. The error percentage for the average improvement in application performance is 0.15689%.
Analysis of the Effect of Capital, Labor, Raw Materials, Length of Business, and Location on MSMEs Income in the Food and Beverages Industry Sector (A Case Study on Home Industry Assisted by the Cooperatives and MSMEs, East Bekasi Districts)
Authors: Laurencia Sharen
Published: December 2022

East Bekasi District has the most significant number of Micro, Small and Medium Enterprises (MSMEs) accompanied by the Bekasi City Cooperatives and MSMEs Office. The food and beverage sector is the largest group compared to others. MSME faces capital difficulties and sales that have yet to be maximized. However, this kind of business is widely carried out considering the convenience and promising market potential. This study aims to determine the variables of capital, labour, raw materials, length of business, and location on the income of MSME actors assisted by the Cooperatives and MSMEs in Bekasi City research is quantitative research. The population in this study were food and beverage MSMEs assisted by the Bekasi City Cooperatives and MSMEs, as many as 145 MSME actors. The sample used was 60 business actors using a simple random sampling technique. The analytical method used is Ordinary Least Square (OLS) using SPSS. The results of this study indicate a positive and significant effect of capital, labour, raw materials, length of business, and location on the income of MSME actors. Capital is the most influential variable on income. The independent variables jointly affect the income of food and beverage MSME actors by 69.7 per cent.
Determinants of Poverty Rate in Eastern Indonesia
Authors: Soleman Riky , Soleman Risky
Published: December 2022

Poverty is a global issue faced by many countries in the world, including Indonesia. The purpose of this study is to examine the level of poverty in Eastern Indonesia by measuring Islamic banking financing, economic growth, LFPR, education and health and inflation against poverty levels in Eastern Indonesia. The data source used in the form of panel data is obtained from the Central Statistics Agency (BPS) for the 2011-2021 period. Data analysis using regression panel data with Common Effect Model (CEM), Fixed Effect Model (FEM), and Random Effect Model (REM) approach processed with E-Views 10. The results of this study indicate that the estimated model chosen in this study is Random The Effect Model (REM) followed by LM testing shows that the results of the Islamic Banking Financing, TPAK, RLS, UHH, and Inflation variables have no significant effect in a negative direction on the poverty level. negative. This means, for example, that there are independent variables simultaneously, so that the poverty level in Eastern Indonesia is increasingly leading to change. Meanwhile, in the simultaneous test the F-Statistic prob value is 0.000000 < 0.05, which means that the six independent variables simultaneously affect the poverty level in Eastern Indonesia. And the value of Adjusted R-Square is 0.607420 which means 60% of the variables of Islamic Banking Financing, economic growth, TPAK, RLS, UHH, and Inflation in this study are able to explain the variation of economic growth variables. While the remaining 40% is explained by other variables outside the model.
Moringa Seed Powder Biocoagulant (Moringa oleifera) for Improving Laboratory Wastewater Quality
Authors: Pujiastuti Peni , Wibowo Yari Mukti , Narimo Narimo
Published: December 2022

The purpose of the study was to examine the ability of 100 mesh size moringa seed powder as a biocoagulant in improving the quality of laboratory wastewater, in terms of parameters: color, TSS, Cu, Fe, COD, P-PO4, and antibacterial. The variable that changed was the concentration of Moringa seed powder solution of 0 mg/L, 40 mg/L, 80 mg/L, 120 mg/L, and 160 mg/L, with fast stirring of 150 rpm for 15 minutes and slow stirring of 50 rpm for 15 minutes. Analysis of test parameters was carried out using standardized methods of wastewater samples before and after the addition of biocoagulants. Characteristics of 100 mesh Moringa seed powder were that with the SEM-EDX test at 5000x magnification. While with the BET-BJH test it had a surface area of 14.519 m2/g, a total pore volume of 0.026 cm2/g, and an average pore size of 7.055. Moringa seed powder could improve the quality of laboratory wastewater and it had good effectiveness. Optimal TSS reduction was at a concentration of 80 % with effectiveness of 81.01 %. The reduction of COD and P-PO4 at a concentration of 160 % biocoagulants had an effectiveness of 96.36 % and 79.36 %. Whilst the decrease in heavy metal Cu was 67.7 %, Fe was 89.33 % and color was 52.96 % with the addition of 120 % biocoagulants. It had antibacterial properties of E-coli and Bacillus at the addition of 200 mg/L biocoagulant as well.
Effect of pH and Ozone Dosage on Characteristic of Ozonated Rice Bran Oil
Authors: Enjarlis E. , Christwardana Marcelinus , Handayani Sri , Fajriah Sofa , Bismo Setijo , Rahmani Jehuda Reinhard , Hazadin Muhammad Tama
Published: December 2022

The influence of pH and ozone dose, as well as ascorbic acid addition during the ozonation process, on the properties of Rice Bran Oil (RBO), was examined. The spectroscopic characteristic of RBO before and after ozonation was analysis directly, while the physicochemical property was assessed by density, viscosity, pH, iodine number, peroxide number, and acid number. With an increase in ozone dose, the carbon double bond in the RBO reduced. The primary product of the ozonation process is ozonide, and one of its by-products is 1,2,4-trioxolane, which contains a carbon single bond as a result of the ozonation reaction. According to this study, the pH 4 and ozone dose of 440 mg O3/L are the optimum parameters utilized in the RBO ozonation process. RBO's density and viscosity were 0.918 g/mL and 0.042 cP, respectively, at these conditions. Its iodine number, acid number, and peroxide number were also 3.173 g/g RBO, 2.3 mg NaOH/g RBO, and 55 mgeq/kg, respectively. Analyses of gas chromatography and nuclear magnetic resonance spectroscopy revealed the presence of 1,2,4-trioxolane. Ozone dosage is critical because greater ozone concentrations place RBO in a saturated state, making the 1,2,4-trioxolane unstable and readily destroyed, whereas lower temperatures can avoid this.