bluuebunny/crossref_metadata_2025 huggingface dataset:
Architectures of syntopia: An interdisciplinary speculative model for constructions with insect-infested wood
Authors: Asa Pelin , Krauthausen Karin , Stock Robert , Dierichs Karola
Published: December 2024

Based on a case study in Franconia, Germany, where beetle infestation of spruce trees is high, we present an interdisciplinary approach from materials science, cultural theory, and computational design to develop architectures for syntopic living. The term syntopy was coined by Luis René Rivas and describes “two or more related species inhabiting the same macrohabitat.” It is a combination of the Greek words syn* for together and *topos for place. Architectures of Syntopia aim to create spatial structures for humans that emanate from and are located in a specific place – a topos. They also include non-human species, creating what Anna Tsing describes as “multispecies worlds“. By interweaving methods from materials science and cultural theory with computational design, different speculative perspectives are developed on one and the same subject: the beetle infestation of the spruce.
The Role of Internet Access for Business Owners in Accessing Kredit Usaha Rakyat (KUR) in Semarang City
Authors: Wahid Aqiel Farhan Hafizh , Rini Ariska Nurfajar
Published: December 2024

This research aims to analyze how internet access affects business owners' decisions to access KUR in Semarang City. The methodology used in this study is quantitative, employing logistic regression analysis with marginal effects, utilizing secondary data from the National Economic and Social Survey (SUSENAS) of Semarang City conducted in 2021. The results reveal a robust positive and statistically significant relationship between internet access and business owners' decisions to access KUR. The availability of the internet equips individuals with valuable resources, information, and a seamless application process, all of which contribute to a heightened inclination towards KUR utilization. Additionally, other variables that demonstrate significant influence include gender, household size, and homeownership status.
Factors Affecting the Sustainability of Halal MSMEs in Yogyakarta: A Study on Literacy, Digitalization, and Fintech
Authors: Maskuri Muhammad Faqih , Febriyanto Ahmad , Baroroh Hilmy , Nurullaily Shulhah
Published: December 2024

This study aims to determine whether financial literacy, digital marketing, financial technology, and financial management affect the sustainability of halal MSMEs in Yogyakarta. This quantitative study uses primary data collection methods through online and offline questionnaires. The sampling technique was a purposive sampling method with a total of 110 respondents who were Halal MSME players in Yogyakarta. The results showed that the four independent variables, namely financial literacy, digital marketing, financial technology, and financial management, had a significant positive effect on the sustainability of halal MSMEs in Yogyakarta. Research related to the sustainability of the performance of halal MSMEs in Yogyakarta has not been widely explored by experts. To the best of the author’s knowledge, studies focusing on the sustainability performance of halal SMEs are still rare, and this literature can complement the exploration of the sustainability of the performance of halal MSMEs, especially in the Yogyakarta area.
Increasing eccentric contraction duration enhances resistance exercise‐induced inhibitory control improvement while reducing the exertion perception: A pilot study in young men
Authors: Dora Kento , Hashimoto Takeshi , Yuuki I. Wayan , Yang Su , Tachi Kousei , Hashimoto Kaito , Fujie Shumpei , Iemitsu Motoyuki , Ogoh Shigehiko
Published: December 2024

Low‐intensity resistance exercise with slow movement and tonic force generation (LRST) effectively improves cognitive inhibitory control (IC) while heightening the subjective perception, which is a barrier to exercise adherence. Compared with concentric (CON) contractions, eccentric (ECC) contractions have greater brain activation related to cognitive functions while decreasing subjective perception. Therefore, we examined whether LRST with a longer duration of ECC contraction (ECC‐LRST) could further enhance exercise‐induced IC improvement while reducing the subjective perception, compared with traditional LRST. Fourteen healthy, young males performed both ECC‐LRST and LRST, with 30% of their one‐repetition maximum. The subjective perceptions of exertion and pain associated with exercise were assessed. IC was evaluated at baseline, immediately post‐exercise, and 15‐min post‐exercise. IC improved immediately after both ECC‐LRST and LRST (both Ps < 0.05). However, the improvement in IC persisted until 15 min post‐exercise for ECC‐LRST compared with baseline (p = 0.031) but not for LRST, which showed a significantly smaller improvement than ECC‐LRST (p = 0.042). A lower perceived pain (p = 0.039) and a trend toward a lower perceived exertion (p = 0.078) were observed during ECC‐LRST than during LRST. ECC‐LRST is an effective resistance exercise protocol for improving IC while reducing the perception of exertion.
The three grand cultural spheres of the Holocene Eurasian Continent
Authors: Han Jianye
Published: December 2024

Based on the typology of ceramic wares and analysis of the spatial distribution, origin, and dispersal of other categories of archaeological remains, it can be determined that three grand cultural spheres existed on the Holocene Eurasian Continent prior to the rise of the Silk Road. These were the Early Eastern Cultural Sphere, centered around the Yellow River valley and the Yangtze River valley; the Early Western Cultural Sphere, centered around the Tigris-Euphrates River valley (Mesopotamia); the Early Northern Cultural Sphere, located to the north of the Eastern and Western Cultural Spheres. Due to cultural interactions, collisions, and exchanges, there were large intersection zones between the three grand cultural spheres.
Preliminary discussions on painted pottery in Neolithic China
Authors: He Jun
Published: December 2024

Chinese painted pottery probably originated during the early Neolithic and developed through the middle to the first half of the late Neolithic period. Flourishing between 6000 and 5000 years ago, it was initially heavily distributed in the middle and lower Yangtze River areas and Haidai region, then spread northward to the middle Yellow River area, and finally reached its zenith during the Taosi culture period. In this process, painted pottery transitioned from “non-ritual vessels” to “ritual vessels.” In certain regions, painted pottery emerged either independently or through the integration of exotic and local traditions; while in others, its use was due entirely to external cultural influences.
Biological evolutionary insights into the origins of agriculture: Evidence from the origin of rice agriculture
Authors: Zhao Zhijun
Published: December 2024

The domestication of plants and animals was a unique evolutionary process influenced by human behavior. In the early stage of domestication, the morphological and genetic characteristics of plants and animals still exhibited wild traits, making the concept of the “earliest” crops and domestic animals relative. Human behavior, acting as an unconscious selection mechanism, influenced the process and rate of domestication, making it a crucial factor in identifying domestication. Archaeological evidence of early cultivation and a sedentary lifestyle indicates that the domestication of rice and the origin of rice agriculture in China spanned four to five thousand years, with significant advancements occurring approximately every two thousand years. The origin of rice agriculture began around 10,000 years ago, entered a critical stage around 8000 years ago, and was completed around 6000 years ago. After this period, farming replaced gathering and hunting as the core of the subsistence economy, leading to the establishment of agricultural societies where agricultural production became the driving economic force.
Tecnologias educativas para adesão ao exame Papanicolau: revisão integrativa
Authors: Cardoso Nathalia de Mattos , Almeida Priscilla Dantas , Araújo Filho Augusto Cezar Antunes de , De Almeida Gomes Margareth Cristina , Pimenta Araújo Paz Elisabete , De Araújo Telma Maria Evangelista
Published: December 2024

Objetivo: identificar na literatura científica as tecnologias educativas aplicadas para adesão ao exame Papanicolau na Atenção Primária à Saúde. Método: revisão integrativa da literatura na qual se incluiu artigos que respondessem à questão norteadora, publicados em português, inglês ou espanhol e se excluiu artigos de revisão, cartas ao editor e editoriais. As buscas foram realizadas em junho de 2024 nas bases: National Library of Medicine, Literatura Latino-Americana e do Caribe em Ciências da Saúde, Base de dados da Enfermagem, Cumulative Index to Nursing and Allied Health Literature e Scientific Electronic Library Online. Resultados: foram incluídos 13 estudos que identificaram palestras, rodas de conversa, cartazes, orientações nas consultas, panfletos, televisão, e atividades na sala de espera como tecnologias educativas Conclusões: o uso das tecnologias educativas pelos profissionais de enfermagem mostra-se como estratégia bem-sucedida para ampliar a adesão de mulheres ao exame Papanicolau em serviços primários de saúde.
PERCEPÇÃO E REPRESENTAÇÃO DE TERRITÓRIO EM CARTOGRAFIA ILUSTRADA
Authors: Kochem Natália
Published: December 2024

Será permitido ao arquiteto e urbanista, descansar um pouco do papel de executor de comandos e redator de atalhos em programas de computador para, para além disto, extrapolar as ferramentas tecnológicas analógicas e digitais de forma a reconquistar uma intenção que busque refletir narrativas conceituais? Há espaço para a exploração da arte na cartografia? O presente trabalho busca analisar os mapas do ilustrador italiano Hugo Pratt, nos quadrinhos Corto Maltese, de acordo com sua narrativa gráfica e representação simbólica através do uso de colagens, de recortes da história associada a cada território retratado e a imensa capacidade de orquestração de recursos na comunicação de seus mapas. Finalmente, busca-se apresentar o conceito de mapeamento subjetivo e mapeamento conceitual como formas de extrapolação da comunicação em mapas, conquista de novos patamares de apreensão, representação e desenho urbano através da captura de percepções complexas da paisagem e representação na cartografia ilustrada.
Exploring Students’ Engineering Design Thinking in The Renewable Energy Topic: A Case of Problem Identification and Developing Ideas and Plans
Authors: Handayani Rif’ati Dina , Lesmono Albertus Djoko , Prastowo Srihandono Budi , Supriadi Bambang , Dewi Nila Mutia , Azis Kharisma Rafian , Thohir Mohammad Anas
Published: December 2024

Science learning provides an opportunity to prepare students with 21st-century Engineering Design Thinking skills (EDT). EDT is a means of looking at and addressing daily real-world problems that greatly need solutions. This study aims to explore students’ EDT skills on alternative energy issues, specifically problem identification and developing ideas and plans. This research is a qualitative exploratory study in a senior high school in the Jember district. The learning design in this study uses the Science Learning through Engineering Design (SLED) models. Research data was gathered through observation and students’ worksheet documents. Content analysis is used as an approach to analyzing data. The results indicated that EDT trains students’ thinking processes to become more critical through problem identification and creativity in developing new ideas and imagination. EDT provides opportunities for students to combine their creativity and critical thinking to produce innovative design solutions. It improves students' epistemic comprehension while studying and helps them acquire relevant knowledge. This research is expected to be supplementary information for teachers to integrate EDT into their learning so that students can achieve meaningfulness and epistemic understanding.
The Role of Video Content in The New York Times and The Guardian’s Coverage of the Israeli War on Gaza
Authors: Kreishan Asem
Published: December 2024

The Israel-Hamas conflict has received widespread coverage from global media sources. The coverage has been extensive, including both conventional news channels and social media platforms, and includes a vast range of opinions and tales. Social media has substantially impacted the dissemination of knowledge, as seen by platforms such as TikTok, which have accumulated billions of views on material relating to this topic. The research revealed a significant discrepancy in the number of postings supporting Palestine compared to those supporting Israel. The battle has resulted in the dissemination of deceptive information and misinformation. Hamas has been prohibited from the majority of social media networks; however, its propaganda continues to flow on channels like Telegram. Local content artists in Gaza recorded their experiences and garnered substantial followings. The study investigates the utilization of video material by newspapers, with a specific emphasis on four key aspects: the characteristics of the content, the intended audience, video editing techniques, and the influence of this content on worldwide public perception. Video coverage in the New York Times strives to provide a fair and equitable portrayal of the Israeli and Palestinian perspectives, including conflicts and fatalities from all sides. The newspaper’s objective is to provide extensive coverage that emphasizes the plight of both parties, however, it has faced criticism for not sufficiently illuminating the agony endured by the Palestinians.
Žurnalistika – rizikinga profesija? Politikos įtaka saugiam žurnalistų įdarbinimui Lenkijoje 2015–2023 metais
Authors: Mateja Magdalena
Published: December 2024

Raising questions about how risky it was (and still is) to practice journalism in Poland, author Magdalena Mateja examines cases from 2015 to 2023, when the Polish government not only regulated the public broadcaster TVP, but also interfered in the management of national commercial television and radio stations. During this period, journalists who did not please the authorities were fired from various media outlets. Among other things, the author concludes that in 2023, after the change of government, the situation of journalists did not improve either in the public broadcaster or in the media market as a whole.
Two Myths about “The Voices”: Experiences of Radio Free Europe/Radio Liberty
Authors: Aleknonis Gintaras
Published: December 2024

The article explores the role of international radio broadcasting, with a specific focus on Radio Free Europe/Radio Liberty (RFE/RL), throughout the Cold War era, particularly in Lithuania and the broader Eastern Bloc context. It analyses the influence of these broadcasts, known as “the Voices,” in countering Soviet propaganda and disseminating alternative news to populations living behind the Iron Curtain. The study highlights two crucial aspects, which the author argues attained near-mythical significance: the messengers (i.e., broadcasters) and the content of their messages. Despite Soviet propaganda’s allegations depicting RFE/RL personnel as detached émigrés, as agents of Western intelligence agencies or as former collaborators with Nazis, the text asserts that RFE/RL maintained journalistic autonomy. The Soviet strategy of jamming international broadcasts was complemented by a myth alleging that during the guerrilla struggle for Lithuanian independence at the onset of Soviet occupation, international broadcasters purposefully exacerbated tensions and disseminated unfounded or even false promises of Western assistance. The article rebuts these claims, noting the absence of international broadcasting in Lithuanian during that period. Drawing from recently disclosed documents from the KGB archives, the article demonstrates that despite censorship and efforts to manipulate information, Western broadcasts continued to shape public opinion and reinforce aspirations for independence and democracy in regions under Soviet control.
Gas-coal fields of the Lviv-Volyn Coal Basin
Authors: Buchynska Iryna , Matrofailo Mykhailo
Published: December 2024

Methane deposits in coal beds are related to unconventional deposits of natural gas. The purpose of the work is to generalize data on the gas presence in the gas-coal fields of the Lviv-Volyn Coal Basin; to ascertain alterations of methane presence of the coal-bearing series across the area of the Lviv-Volyn Coal Basin.
We have analyzed gas-coal deposits of the Lviv-Volyn Coal Basin. General view of the change in methane presence across the area of the basin is the following:
– of the Volyn field seams of the Bashkirian stage have the least methane presence. Thus, for the seam b3 it doesn’t exceed 0.1–1. cu m/t. dry ash-free mass (cu m/t. a.-f. m.), and for the seam b1, it is equal to 0.2–3.0 cu m/t. a.-f. m.). The methane presence the Serpukhovian stage is higher and is changed within on a large scale from 0.01 to 3.0 cu m/t. a.-f. m. In the northern part of the basin, at the Volyn field the commercial coal seams have insignificant methane presence from 0.01 to 1.4 cu m/t. a.-f. m. Only is the far north-west it is increased up to 4–8 cu m/t. a.-f. m.;
– in the northern and north-eastern parts of the Zabuzhzhia field, the methane presence of coalbeds of the Serpukhovian stage is from 0.01 to 1. cu m/t. a.-f. m. With the increase in the depth of occurrence up to 500–650 m in the south-western part of the field, the methane presence increases to 2–10 cu m/t. a.-f. m. and at some plots it reaches 12–17 cu m/t. a.-f. m.;
– іn the Mezhyrichchia field the methane presence of the seams n11, n12, as well as of the main working seams of north-eastern part and along their outcrops into Carboniferous hardly reaches 3–5 cu m/t. a.-f. m. Characteristic of the field is that with increase of the depth of occurrence of beds from 380 to 450 m in the east and to 500–570 m in the west, the methane presence increases from 3–8 to 5–17 cu m/t. a.-f. m.;
– in the Tyagliv field, the methane presence of coalbeds reaches of its maximum and in the depth of 800–870 m it is from 8 to 31 cu m/t. a.-f. m. Тhe Tyagliv field is the most gas-bearing in the Lviv-Volyn Coal Basin;
– in the Lyubelya field, in its southern part, coal-bearing bearing series up to coal seam n7 is degassed, and the methane content in the gas mixture is from 0 to 0.8 cu m/t. a.-f. m. In the northern direction of the field the methane presence increases to 5–15 cu m/t. a.-f. m., and in the seam v6 up to 20 cu m/t. a.-f. m. at the mine fields No. 4 and No. 5.
To ascertain prospects of the areas for commercial extraction of coalbed methane it is necessary to take all geological factors, influencing the spreading and distribution of coal gases, into consideration. Complex approach to coal production with studying gas bearingness in the gas-bearing series is very important for the perspectiveness of the areas. The usage of such methods is one of the perspective directions of a stable development of coal-producing regions with gradual transfer from the monocentrified production to the multiprofile purposefulness.
POTENTIAL GOLD RESOURCES OF THE SAVRAN ORE FIELD
Authors: Sukach V.V. , Vasylenko A.P. , Pavliuk O.V.
Published: December 2024

Ukraine possesses a significant gold ore potential with total resources of precious metal exceeding 3000 tons, of which about 2400 tons are concentrated in the Ukrainian Shield. Among the list of potentially industrial deposits, the Mayske deposit stands out as a crucial site within the Savran gold ore field (SaRF) in the Pobuzhia ore district. This article examines the geological and structural setting of the SaRF and provides data on its prospective and forecasted gold resources, which have been tested and approved during the period from 2011 to 2023 by the Expert Commission on Monitoring the Resource Base of Ore, Non-metallic, and Solid Combustible Minerals. The Savran ore field comprises 11 gold ore sites with varying degrees of exploration, including the Mayske deposit and the ore occurrences of Kvitka, Kapustianka, Chemerpil, Mohylne, Baksha, Savran, Polyanetske, Nedilkove, Bohdanivka, and Zavallia. Among these, the Mayske deposit and the Kvitka ore occurrence are the most thoroughly studied and are included in the Subsoil User’s Investment Atlas. The total resource potential of gold in the SaRF is estimated to be over 470 tons. By considering the spatial location, geological criteria, and similar exploration indicators, it is recommended to treat these deposits as a single investment project. This strategy would not only streamline the exploration and development process but also maximize resource utilization and economic returns. The favorable mining conditions of the weathering crusts, including their shallow depth and higher gold content, make them particularly attractive for investment, ensuring lower costs and higher efficiency in extraction and processing. Special attention should be given to gold ore deposits in weathering crusts, which are characterized by shallow ore body occurrence, relatively high gold content, and less expensive processing and enrichment compared to basement rock mineralization. This approach would facilitate a streamlined exploration and development process, maximizing resource utilization and economic returns.
PETROLOGICAL AND GEOCHEMICAL SPECIFICS OF PRECAMBRIAN PLAGIOGRANITOIDS IN THE UKRAINIAN SHIELD
Authors: Kryvdik S.G.
Published: December 2024

A petrogenetic hypothesis of incoherent trace elements distribution between basic and acid melts is proposed that explains geochemical peculiaties of Precambrian enderbites and plagiogranitoids of tonalite-trondhjemite-granodiorite (TTG) series. The last are predominantly characterized by low REE concentration and positive Eu/Eu* in chondrite normalized patterns. It is demonstrated that Eu/Eu* positively correlates with REE concentration in Precambrian enderbites and plagiogranitoids: by low REE concentration Eu/Eu* is positive and by increased REE concentration Eu/Eu* become negative. In typical enderbites and Precambrian plagiogranitoids Eu/Eu* are positive but in charnokites and Na-K-granitoids Eu/Eu* are negative. REE, Nb, Zr, and Rb concentration in different Precambrian and Phanerozoic plagiogranitoids are given. The meso- and melanocratic enderbites with high REE and Nb contents and negative Eu/Eu* are separately distinguished. It is assumed that such rocks could be formed from melts definitively non-separated in melanocratic (basic) and leucocratic (acid) differentiates.
Az ISO/IEC 27001 szabvány elmélete és gyakorlati alkalmazása OT/ICS-rendszerek kiberbiztonsági jelentéseinek tükrében
Authors: Hunorfi Péter
Published: December 2024

Az ISO/IEC 27001 szabvány alkalmazása lehetővé teszi az OT-rendszereket üzemeltető szervezetek számára, hogy egy átfogó és koherens biztonsági stratégiát alakítsanak ki, amely integrálja a kockázatkezelést és az információvédelem legjobb gyakorlatait. Az ISO/IEC 27001 kiemeli a felső vezetés elkötelezettségének szükségességét, a hatókör pontos meghatározását, a kockázatértékelést, a megfelelő biztonsági kontrollok kiválasztását és a rendszer folyamatos felülvizsgálatát és fejlesztését. Ezek a lépések kulcsfontosságúak az OT-rendszerek biztonságának fenntartása és a kibertámadásokkal szembeni védelem megerősítése érdekében. Az ISO/IEC 27001 alkalmazása OT-környezetben nemcsak a biztonsági intézkedések hatékonyságát növeli, hanem hozzájárul az üzleti folytonosság fenntartásához, az ügyfelek bizalmának növeléséhez és a szabályozási követelményeknek való megfeleléshez is. A közelmúltban megje-lent hazai és nemzetközi, OT/ICS-rendszerekre vonatkozó kiberbiztonsági jelentések legfőbb konklúziója, hogy a fenyegetettségek száma és kifinomultsága folyamatosan növekszik. A nemzetek és a szervezetek alapvető érdeke ezeknek a kockázatoknak a minimalizálása, valamint OT/ICS-rendszereik minél hatékonyabb védelme a kibertérben. Ennek legmegfelelőbb módja a kibervédelem szabványalapú megközelítése és az ajánlások hatékony alkalmazása. Ez a cikk bemutatja az ISO/IEC 27001 gyakorlati alkalmazásának kulcsfontosságú lépéseit, előnyeit és gyakorlati hasznosítását OT/ICS-rendszerek vonatkozásában.
Photochemical and Sono-Photochemical Studies of Zn (II) Porphyrin-conjugated Chitosan Hydrogels for Enhanced Singlet Oxygen Generation
Authors: Önal Emel
Published: December 2024

This study explores the synthesis, characterization, photochemical, and sono-photochemical properties of covalently conjugated porphyrin-chitosan hydrogels for potential application in photodynamic therapy (PDT) and sono-photodynamic therapy (SPDT). The efficient production of singlet oxygen, a crucial reactive oxygen species (ROS) in these therapies, was investigated. Zinc(II) porphyrins 1 and 2 were synthesized by metal insertion to free based porphyrins and covalently linked to chitosan via Schiff-base reaction to produce chitosan hydrogel CS-1 and CS-2 (conjugation via phenylacetylene spacer). The synthesized compounds were characterized using standard spectroscopic techniques, confirming successful conjugation. Scanning electron microscopy (SEM) analysis demonstrating the homogeneous distribution of porphyrins within the hydrogel matrix. Photophysical and photochemical properties, including ground state absorption and singlet oxygen generation, were evaluated for both porphyrin complexes and chitosan-conjugated hydrogels in DMSO. The porphyrin-hydrogel structures showed superior singlet oxygen generation efficiency. Sono-photochemical studies showed further enhanced singlet oxygen generation, with the highest quantum yield (ΦΔ= 0.81) observed for the chitosan hydrogel CS-2. The results demonstrated enhanced singlet oxygen generation in the hydrogel structures, particularly under simultaneous ultrasound and light irradiation, indicating their potential efficacy in PDT and SPDT applications. Additionally, photo degradation studies revealed the stability of the synthesized compounds under light irradiation. These findings highlight the potential of porphyrin-conjugated chitosan hydrogels as effective photosensitizers for PDT and SPDT applications.
Effect of Doxorubicin-Loaded Tetraborate Nanoparticles on HUVEC Behavior for Tumor Angiogenesis
Authors: Çetin Altındal Damla
Published: December 2024

Angiogenez, tümör büyümesini destekler ve yakın dokulara metastazı kolaylaştırır, bu nedenle inhibisyonu kanser tedavisinde ana hedeflerden biridir. İnsan göbek kordonu venöz endotel hücreleri (HUVECler), kan damarlarının oluşumundaki rolleri nedeniyle in vitro angiogenez çalışmalarında sıklıkla kullanılmaktadır. Bu çalışma, doxorubisin (Dox) ile yüklenmiş kalsiyum tetraborat nanopartikülleri (CaB4O7-Dox) ve magnezyum tetraborat nanopartiküllerinin (MgB4O7-Dox) HUVEC davranışları üzerindeki etkilerini incelemekte olup, hücre proliferasyonunu inhibe etmeyi ve kanser tedavi etkinliğini artırmayı amaçlamaktadır. CaB4O7 ve MgB4O7 nanopartiküllerinin boyutları sırasıyla yaklaşık 200 nm ve 300 nm olarak belirlenmiştir. Sitotoksisite çalışmaları, Dox'un HUVECler için yaklaşık 350 ng/mL (440 nM) IC50 değerine sahip olduğunu göstermiştir. Dox ile yüklenmiş kalsiyum ve magnezyum tetraborat nanopartikülleri, HUVEC proliferasyonunu inhibe etmede serbest Dox ve kontrol gruplarına göre belirgin derecede üstündür. Ayrıca, bu nanopartiküller hücre morfolojisini önemli ölçüde değiştirmiş ve tüp oluşum eğilimini bozmuştur, bu da anti-anjiyogenik etkilerini göstermektedir. Bu bulgular, Dox ile yüklenmiş tetraborat nanopartiküllerinin HUVEC davranışını ve anjiyogenezini etkili bir şekilde modüle ettiğini ve bu nanopartikül bazlı sistemlerin kanser tedavilerinin etkinliğini artırma potansiyelini vurgulamaktadır.
Factors of Transformation of Old Industrial Regions into Potential “Growth Centres” of the Russian National Economy
Authors: Sorokina Natalia
Published: December 2024

The significance of the study lies in the fact that the effectiveness of the regional policy of the state is largely determined by understanding the factors that determine the prospects for the development of various types of regions. The object of the study is old industrial regions – a special type of industrial region with the potential to transform into “growth centres” of the Russian Federation. The purpose of the study is to substantiate the composition and build a hierarchy of factors determining the prospects for the transformation of old industrial regions into potential “growth centres” of the national economy of Russia. The author substantiates the identification of three groups of factors: factors determining the region’s ability to self-development; factors determining the potential of the region’s participation in the processes of interregional interaction; factors of the functioning of development institutions. In relation to each group, a content analysis of normative legal acts and authoritative publications of economic periodicals was carried out, which made it possible to substantiate the composition of second-order factors, the selection of which is based on the criterion of manageability. The factors determining the ability of an old industrial region to self-develop are: the state of investment processes in the region; the level of innovative development; the financial condition of the region; and the standard of living of the population. Among the factors determining the potential of the region’s participation in the processes of interregional interaction, the most significant are the development of transport infrastructure, migration activity of the population, and the level of digitalization. The nature of the influences of the factors of the functioning of development institutions depends on which type of institution – support for economic growth or regional policy – has an impact on the socio-economic development of the region. The proposed system of factors makes it possible to take into account the peculiarities of old industrial regions and their role in the functioning of the national economic system of the country and, therefore, can be used for the purposes of a differentiated regional policy for the development of old-industrial regions of Russia.
Prerequisites and Prospects of Digital Transformation of Public Administration at the Regional Level
Authors: Mantaeva Elza , Slobodchikova Inna , Goldenova Viktoriya
Published: December 2024

The article focuses on the digital transformation of regions as a crucial component of their socio-economic development. The authors emphasise that building a digital ecosystem allows improving the quality of life of the population and the efficiency of state and municipal governance. The key direction of digital transformation is the creation of digital infrastructure: the introduction of new technologies, increasing the availability of public services in electronic form, etc. The authors focus on the development of digital infrastructure. Special attention is paid to the development of digital literacy in the population through training courses and the creation of various digital services. The Ministry of Digital Development is responsible for the implementation of digital transformation in the Republic of Kalmykia, which performs a wide range of functions: from strategic planning to organising interdepartmental electronic interaction and maintaining registers of information systems. The article discusses the main areas of activity of the Ministry of Digital Development of the Republic of Kalmykia, as well as the legal and regulatory framework governing the digital transformation of the region. The authors conclude on the importance of an integrated approach to digitalisation as a key factor in the socio-economic development of territories.
Small Town Branding in the Regional Dimension: Methodological Approach
Authors: Fedorov Andrey , Medvedeva Lyudmila
Published: December 2024

It is shown that modern approaches to small town branding should be based on a theoretical understanding of existing theories, their empirical verification, and the application of spatial econometrics. The importance of O.V. Inshakov’s research on unification of conceptual approaches in building spatial development models and activation of “growth points” in the face of small and medium-sized settlements is noted. The purpose of the study was to form a methodological approach to managing the process of small town branding. The work used system and axiological approaches, economic-mathematical, and project modeling. The conducted meta-analysis showed that branding of territories does not take into account their size and investment opportunities, and the process itself is reduced to disseminating the brand in social networks. In most cases, the brand of a small town acts as an object of empathy for the local community, which is interested in its ownership with a share of “exclusivity and uniqueness.” The brand “Kotelnikovo – Land of Heroes” formed in the city of Kotelnikovo in the Volgograd Region has made it possible to intensify external relations, attract public and private investment, and increase the tourist flow. The proposed models of project solutions for branding small towns provide organizational, legal, and economic conditions for the development of city infrastructure and improving the quality of life of the population. The methodological approach to branding small cities based on social partnerships between official institutions and society contributes to the inflow of investment and economic development.
ST-segment elevation acute coronary syndrome in a child with Duchenne muscular dystrophy: a case report
Authors: Tatarintseva Z. G. , Babicheva O. V. , Barbuhatti K. O.
Published: December 2024

Introduction. Duchenne muscular dystrophy is an X-linked muscle disorder caused by the dystrophin absence. This leads to the death of muscle cells and cardiomyocytes and their subsequent replacement with adipose and fibrous tissue. Clinically, this disease manifests itself as progressive muscle weakness and cardiomyopathy. We report a case of a young patient with acute myocardial injury without coronary artery occlusion due to Duchenne muscular dystrophy.

Brief description. A 15-year-old male patient with Duchenne muscular dystrophy, no risk factors for coronary artery disease and known cardiac diseases presented with pressing chest pain. Electrocardiography showed ST segment elevation on the inferior and lateral walls. Given the pressing chest pain, electrocardiographic abnormalities and elevated cardiac biomarkers, an initial working diagnosis of acute myocardial infarction was made and the patient was taken to the catheterization laboratory for coronary angiography, which demonstrated normal cardiac anatomy and coronary arteries without hemodynamically significant stenoses. The patient was discharged from the hospital on day 14 with a final diagnosis of Duchenne muscular dystrophy cardiomyopathy and recommendations for perindopril 5 mg daily and bisoprolol 5 mg daily.

Discussion. Frontline practitioners should be aware of the high prevalence of car diomyopathy in patients with Duchenne muscular dystrophy, which increases with age. Cardiac biomarkers may be chronically elevated in this disease. However, a high suspicion combined with echocardiography and magnetic resonance imaging may help in diagnosing acute myocardial injury in these cases. Based on this case, we discuss the dilemmas of management and follow-up of this complex group of patients.
Severe infective endocarditis in a patient with hypertrophic obstructive cardiomyopathy: 12 years after combined surgery. A case report
Authors: Lutokhina Yu. A. , Osadchaya V. A. , Morozova N. V. , Chichkova N. V. , Ganieva N. A. , Pigalitsyna M. A. , Dzemeshkevich S. L.
Published: December 2024

Brief description. A 40-year-old male patient with obstructive hypertrophic cardiomyopathy (HCM) developed episodes of fever up to 39,0° C after carotid endarterectomy. Mitral and aortic valve Enterococcus faecium-induced infective endocarditis was diagnosed. Antibacterial therapy was continued for 3 months. As a result, the infectious and inflammatory process was suppressed, but severe mitral and aortic valve insufficiency required surgical treatment.

During the operation, the patient underwent replacement of both affected valves, as well as extended myectomy and cardioverter-defibrillator implantation to prevent sudden cardiac death. Twelve years after surgical treatment of infective endocarditis and HCM, the patient's condition is stable.

Discussion. Patients with HCM have an increased risk of infective endocarditis, but with timely diagnosis and active treatment of endocarditis, a good long-term prognosis is possible. In this case, the combined surgery played an extremely important role.
Danon disease in women: a modern view of the problem: a case series
Authors: Myasnikov R. P. , Nefedova D. A. , Kuzina N. N. , Kulikova O. V. , Gagarina E. V. , Mershina E. A. , Drapkina O. M.
Published: December 2024

Introduction. Danon disease is a rare cardiomyopathy (CMP) with multisystem involvement, which is associated with lysosome-associated membrane protein 2 (LAMP2) gene polymorphisms. This protein is the most important regulator of autophagy and is produced mainly in the myocardium, skeletal muscles and brain. This is reflected in the classic disease triad: hypertrophic CMP, skeletal myopathy and cognitive impairment. Danon disease is characterized by maximum penetrance regardless of sex. Expressivity is much less predictable in women, given the X-linked dominant inheritance and mosaicism of cellular production of the LAMP2 protein as a result of random inactivation of one of the X chromosomes.

Brief description. The article presents two clinical cases demonstrating different disease courses in women with Danon disease. The analysis of case records, clinical performance, paraclinical data were carried out.

Discussion. In recent years, the widespread development of molecular genetic diagnostics and imaging methods has led to the accumulation of data on natural course and prognosis of Danon disease. It became clear that in female patients with Danon disease, previously considered mainly as mutation carriers, clinical manifestations can vary from low-symptom phenotypes with isolated CMP to severe multisystemic involvement and early onset. Raising awareness among practitioners about the Danon disease specifics in women, multidisciplinary examination, and genetic testing are the basis for timely diagnosis, risk stratification, and treatment initiation.
Familial hypertrophic cardiomyopathy with midventricular obstruction associated with MYH7, FHOD3 and BAG3 gene variants: a case report
Authors: Andreeva S. E. , Marusova M. O. , Bortsova M. A. , Kostareva A. A.
Published: December 2024

Introduction. Hypertrophic cardiomyopathy (HCM) with midventricular obstruction (MVO) represents a subgroup of increased risk of adverse outcomes. It contributes to development of apical aneurysm, which is an anatomical substrate for the development of malignant arrhythmias, thromboembolism, as well as progression to end stage systolic heart failure. Genetic causes of HCM with MVO are poorly described in Russian and foreign literature.

Brief description. We present a case of a 54-year-old female patient with a familial HCM with isolated MVO and rare missense variants in the MYH7, FHOD3 and BAG3 genes. The clinical performance was represented by a paroxysmal atrial fibrillation, as well as episodes of nonsustained ventricular tachycardia.

Discussion. According to the European HCM Risk-sudden cardiac death (SCD) calculator, the patient was stratified into an intermediate risk group. However, we also took into account gadolinium-enhanced myocardial areas according to magnetic resonance imaging, as well as no conditions for MVO surgery. This was key in determining the indications for a cardioverter-defibrillator implantation within primary SCD prevention.
An Overview of Credit-Building Products
Authors: Bruce Alexander , Hannon Simona M.
Published: December 2024

Credit-building products are secured small-dollar products that allow consumers to either establish or improve their credit scores by having lenders report their payment activity to credit bureaus. Examples include secured credit cards or loan products such as credit-builder and passbook loans.
Corporate Debt Maturity Matters for Monetary Policy
Authors: Jungherr Joachim , Meier Matthias , Reinelt Timo , Schott Immo
Published: December 2024

We provide novel empirical evidence that firms’ investment is more responsive to monetary policy when a higher fraction of their debt matures. In a heterogeneous firm New Keynesian model with financial frictions and endogenous debt maturity, two channels explain this finding: (1.) Firms with more maturing debt have larger roll-over needs and are therefore more exposed to fluctuations in the real interest rate (roll-over risk). (2.) These firms also have higher default risk and therefore react more strongly to changes in the real burden of outstanding nominal debt (debt overhang). Unconventional monetary policy, which operates through long-term interest rates, has larger effects on debt maturity but smaller effects on output and inflation than conventional monetary policy.
Dönüm Noktalarıyla Yahudilerin Amerika'ya Göç Serüveni
Authors: Güngör Muhammed
Published: December 2024

Yahudilerin Amerika’ya göç serüveni 1654 yılında 23 kişilik Yahudi bir topluluğun Kuzey Amerika’daki New Amsterdam’a (New York) gelmesiyle başlamış ve daha sonraki yıllarda da devam etmiştir. Bu göç serüveni başlıca üç döneme ayrılmıştır. Bu dönemlerin isimlendirilmesinde Avrupa’dan Amerika’ya göç eden Yahudilerin Avrupa’daki etnik kökenleri etkili olmuştur. Bu dönemler 1654-1820 yılları arasını kapsayan Sefarad Dönemi, 1820-1880 yılları arasını ifade eden Alman Dönemi ve son olarak 1881-1924 yılları arasını niteleyen Doğu Avrupa Dönemi’dir. 1654-1820 yılları arasını kapsayan Sefarad Dönemi kendi içinde Sömürge Dönemi (1654-1776) ve Erken Ulusal Dönem (1776-1820) şeklinde iki döneme ayrılmaktadır. Sömürge Dönemi de ayrıca Hollanda Dönemi (1654-1664) ve İngiltere Dönemi (1664-1776) şeklinde tasnif edilmiştir. Almanya’da ve daha sonraki süreçte Çarlık Rusya’da yaşayan Yahudilerin düştüğü zor durumlar, bunların aleyhine çıkartılan yasalar, baskı ve zulüm altıda yaşamak zorunda bırakılmaları ve büyük ekonomik sıkıntılar Yahudilerin Yeni Dünya olarak bilinen Amerika’ya göç etmelerini zorunlu kılmıştır. Her bir göç dalgasında Yahudiler, büyük sıkıntılarla karşılaşmışlardır. Eğitimsiz ve parasız olmaları, ailelerini geride bırakmak zorunda olmaları, İngilizce bilmemeleri ve hatta kimliklerinin Yahudi olması yaşadıkları sıkıntıların başlıca sebepleridir. Bütün bunlara rağmen Amerikan Yahudileri, zamanla ekonomik, eğitim, siyaset ve kültür bağlamında yeni hak ve özgürlükler elde etmişlerdir. Bu özgürlük ortamında neredeyse her alanda hayal edemeyecekleri kadar büyük başarılar kazanmışlardır. Amerika’da seyyar satıcı olarak işe başlayan Yahudiler, mağazalar açacak ve hatta bankalar kuracak kadar zenginleşmişlerdir. Eğitimsiz Yahudilerin çocukları doktor, avukat ve öğretmen olarak kendilerini ispatlamışlardır. Bu başarıları kazanırken zaman zaman büyük sıkıntıların üstesinden gelmek zorunda kalmışlardır. Bütün bunların sonucunda Amerika yedi milyona yaklaşan Yahudi nüfusuyla İsrail’den sonra Yahudilerin ikinci vatanı olmuştur. Öte yandan, dünya siyasetinde ve ekonomisinde etkin rol oynayan Amerikan Yahudilerinin göç tarihini ana hatlarıyla ortaya koymanı amaçlayan bu çalışma, bizzat Amerikan Yahudilerinin ve bunların gücünün anlaşılmasına katkı sağlaması açısından önem arz etmektedir.
ИНСТИТУТ НАСТАВНИЧЕСТВА И ПРОБЛЕМЫ ЕГО РАЗВИТИЯ В СОВРЕМЕННОМ РОССИЙСКОМ ОБЩЕСТВЕ
Authors: Чистяков Анатолий Васильевич , Сусименко Елена Владимировна , Щербакова Лидия Ильинична
Published: December 2024

Целью исследования выступает анализ специфики функционирования института наставничества и основных проблем его развития в современном российском обществе.
Методологическую базу исследования составляют ключевые положения институционального подхода, предусматривающего рассмотрение наставничества в качестве социального института со свойственными ему функциями, и деятельностного подхода, в рамках которого оно трактуется как определенный вид деятельности, основной целью которой является поддержка комплексного характера, реализуемая в отношении молодых работников, а также создание благоприятных условий для реализации личностного потенциала в трудовой организации.
Результаты исследования. Наставничество выступает в качестве древнейшего способа передачи опыта из поколения в поколение: в различные исторические периоды оно приобретало специфические характеристики и применялось в различных формах, однако в широком смысле наставником всегда считался такой человек, который обладал способностью к трансляции профессиональных и иных знаний и опыта другому лицу или определенной социальной группе. Институт наставничества призван готовить молодое поколение к эффективной реализации трудовой деятельности в условиях постоянно меняющейся социальной реальности, создавать возможности для максимально полного развития молодых работников в рамках выбранных ими профессий, постоянного повышения уровня квалификации и мастерства. Наставничество предполагает сочетание различных видов деятельности, к числу которых относится деятельность диагностического характера, связанная с анализом личностных характеристик наставляемых лиц, выявлением присущих им недостатков, могущих стать препятствиями на пути построения карьеры, реализации творческого и иного потенциала, а также профессионально-обучающая и воспитательная деятельность, предусматривающая передачу молодым работникам набора профессиональных знаний и компетенций, формирование личностных качеств, способствующих эффективному осуществлению трудовой деятельности.
Перспективу исследования составляет последующее изучение основных проблем формирования и перспектив развития института наставничества в современной России, определение новых эффективных форм и средств реализации наставнической деятельности.
An Analysis of the Hierarchic Structure in Educational Organizations
Authors: Doğan Soner , Akalın Deniz , Tunçer Günay Emine
Published: December 2024

Although hierarchy in organizations emerges as a deep-rooted structural component, the hierarchical structure of educational organizations, which come to the fore with the intensity of human interaction, differs from others. The research aims to evaluate the hierarchical structure existing in educational organizations according to the opinions of administrators in different aspects. In this research, which was structured with qualitative research method, phenomenology design was used. The data of the study were obtained from face-to-face in-depth interviews with a total of 9 school administrators, 3 from the primary school, 3 from the secondary school and 3 from the secondary education level, and the data were evaluated by content analysis method. According to the results, it was determined that the participants explained the concept of hierarchy mostly with the concepts of discipline and order, and discussed the hierarchical structure and the importance of the hierarchical structure within the framework of the concepts of corporate governance and existence. It was seen that the administrators, as a subordinate, handled their relations with the provincial/district MEM within the framework of the concepts of duty ethics. As a superior, his/her relations with the vice principals were explained with the concepts of duty and responsibility, balanced relations, and his relations with the teachers as a superior were explained with the concepts of duty and responsibility, and team spirit. According to the results, it is recommended that all stakeholders fulfill their duties and responsibilities within the framework of professional ethics in order to ensure order and discipline.
Derecho y políticas ambientales en Extremadura (Segundo semestre 2021)
Authors: Brufao Curiel Pedro
Published: December 2024

Derecho y políticas ambientales en Extremadura (Segundo semestre 2021)
Jurisprudencia ambiental en Extremadura (Segundo semestre 2021)
Authors: Brufao Curiel Pedro
Published: December 2024

Jurisprudencia ambiental en Extremadura (Segundo semestre 2021)