bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Study of Pediatric Patients with Complete vs. Incomplete Kawasaki Disease in a Tertiary Hospital: An Eleven Year Review
Authors: Malimban Janine , Garcia Robert Dennis , Francisco-Mallari Maria Ronella
Published: October 2022

Introduction: Kawasaki disease (KD) is the leading cause of acquired heart disease in childhood, but its diagnosis remains challenging since a significant number of cases do not meet the diagnostic criteria (Incomplete KD). This may delay the diagnosis and initiation of treatment, and increase the risk of morbidity from coronary artery complications. Objectives: This study compared the clinical profile and treatment outcomes of children with complete and incomplete KD. Methods: This is a cross-sectional, retrospective study of pediatric patients diagnosed with KD and admitted in a tertiary hospital from January 1, 2010 to December 31, 2020. Demographics, clinical manifestations, laboratories, 2D echocardiography (2DE) findings and treatment outcomes were obtained by review of medical records and analyzed using descriptive statistics. Results: Among 135 patients studied, 71% were classified as Incomplete Kawasaki Disease. Majority (89%) were children more than 1 year old and predominantly male (55%). Five classic features, other than fever, were more frequent in complete KD – bilateral bulbar conjunctivitis, mucosal changes in the lip and oral cavity, polymorphous exanthem, changes in extremities, and cervical lymphadenopathy. Fever (100%), conjunctivitis (100%), rashes (97%) and oral changes (90%) were the most common findings in complete KD, while fever (100%), rashes (56%), conjunctivitis (46%) and oral changes (35%) were noted in incomplete KD. Higher CRP (167 mg/L vs. 100 mg/L) and lower albumin levels (30 g/L vs. 38 g/L) were seen in complete KD. Coronary artery dilatation (56% vs. 48%) was frequently detected in both complete and incomplete KD. Majority (96%) of cases received only one dose of IVIG and 4% needed additional treatment with methylprednisone. Conclusion: The five principal features of KD other than fever, elevated CRP and lower albumin levels were significantly more common in complete cases. No significant differences in the demographics and 2DE findings of children with complete and incomplete KD were observed.
Antara Aqidah dan Akhlak dalam Pendidikan Islam: Suatu Tinjauan Kritis
Authors: Zulianah Nurul Ainin, Dewi , Zulianah Dewi
Published: October 2022

Keberadaan muatan materi dalam pendidikan islam sangat beragam dan kompleks. Salah satu di antaranya adalah perihal aqidah dan akhlak. Pemahaman umum terkait aqidah bergerak pada ranah teologis, keimanan, dan ketakwaan. Sedangkan akhlak berkutat pada ranah pembentukan karakter siswa. Tugas utama lembaga pendidikan adalah untuk membentuk kepribadian yang unggul, merancang untuk mengedepankan kepekaan sosial, dan menanamkan pentingnya moralitas. Urgensi dalam pendidikan islam dalam mengembangkan bagaimana pentingnya pemahaman terkait pemisahan antara aqidah dan akhlak bertujuan untuk memberikan gambaran bagaimana konsepsi yang diusung dalam muatan materi dalam proses pembelajaran. Selain itu, kompleksitas pemahaman ini sekaligus bertujuan untuk memberikan jawaban secara preventif terkait dengan gelombang modernitas yang menghinggapi dunia pendidikan islam.

Kata Kunci: Aqidah, Akhlak, Modernitas, Tindakan Preventif, Pendidikan Islam.
Perancangan Sistem Informasi Manajemen Pengarsipan Data Pegawai Menggunakan Electronical Filling System (Efs) Pada Kantor Camat Donri-Donri Kabupaten Soppeng
Authors: Tahir M. Afdal
Published: October 2022

Penelitian bertujuan untuk mengembangkan sebuah sistem informasi manajmen data pegawai di Kantor Camat Donri-Donri Kabupaten Soppeng yang dapat mengatasi permasalahan pengolahan data pada sistem yang lama, terutama pengelolaan arsip dokumen data kepegawaiaan. Dalam penelitian ini digunakan Electronic Filling System (EFS) dimana arsip yang sudah mengalami perubahan bentuk fisik dari lembaran kertas menjadi lembaran elektronik. Adapun tahapan penelitian terdapat tiga tahapan utama yaitu analisa system, perancangan system dan implementasi sistem. Data yang dikumpulkan dianalisis dengan metode deskripsi. Hasil analisis selanjutnya dijadikan acuan untuk merancang sistem dengan menggunakan Data Flow Diagram (DFD). Hasil dari tahap perancangan akan diimplementasikan dengan menggunakan bahasa pemrograman web PHP dengan bantuan Framework Codeigniter. Dari pengujian aplikasi sistem dengan menggunakan whitebox testing, dapat disimpulkan bahwa sistem informasi yang dikembangkan dapat melakukan proses sesuai dengan harapan peneliti dan pihak Kantor Camat Donri-Donri sebagai pengguna . Diharapkan dengan adanya Sistem Informasi Manajemen Data Pegawai Menggunakan EFS di Kantor Camat Donri-Donri Kabupaten Soppeng ini dapat meningkatkan pelayanan administrasi kepegawaiaan
Analisis Keamanan Jaringan Hotspot Dengan Parameter Quality Of Service (Qos) Pada Kantor Dinas Komunikasi Dan Informatika Kabupaten Soppeng
Authors: Nurnaningsih  , Riskayani  , Anniar Husnang
Published: October 2022

Penelitian ini membahas tentang Analisis Keamanan Jaringan Hotspot dengan Parameter Quality of Service (QoS) Pada Kantor Dinas Komunikasi dan Informatika Kabupaten Soppeng. Penelitian ini bertujuan untuk mengetahui kualitas keamanan jaringan hotspot pada kantor Dinas Komunikasi dan Informatika Kabupaten Soppeng. Jenis penelitian yang digunakan adalah penelitian Kualitatif. Tehnik pengumpalan data yang digunakan dalam penelitian ini adalah Observasi, Wawancara dan Analisis. Berdasarkan Analisis yang dilakukan, diperoleh bahwa kualitas jaringan hotspot pada kantor Dinas Komunikasi dan Informatika Soppeng pada jam tidak sibuk kerja maupun pada jam sibuk kerja masih tergolong bagus dan kualitas keamanan jaringan hotspot pada kantor Dinas Komunikasi dan Informatika Soppeng kuat sehingga tidak dapat dilakukan sniffing
SentiLexBR: An Automatic Methodology of Building Sentiment Lexicons for the Portuguese Language
Authors: De Melo Tiago
Published: October 2022

User reviews are readily available on the Web and widely used for sentiment analysis tasks. Sentiment lexicons plays an important role in sentiment analysis, where each sentiment word is given a sentiment label (positive or negative) or score (1 or -1). However, a sentiment lexicon may express different sentiment polarity according different domain. In addition, only a few studies on Portuguese sentiment analysis are reported due to the lack of resources including domain-specific sentiment lexical corpora. In this paper, we present an effective methodology, called SentiLexBR, using probabilities of the Bayes’ Theorem for building a set of sentiment lexicons. An unsupervised algorithm is proposed to automatically identify sentiment lexicons with their polarities for the Portuguese language. Experimental results on user reviews datasets in 12 different domains indicate the effectiveness of our methodology in domain-specific sentiment lexicon generation for Portuguese. In addition, the sentiment lexicon produced by SentiLexBR also significantly outperforms several alternative approaches of building domain-specific sentiment lexicons.
KoopaML, a Machine Learning platform for medical data analysis
Authors: García-Holgado Alicia , Vázquez-Ingelmo Andrea , Alonso-Sánchez Julia , García-Peñalvo Francisco José , Therón Roberto , Sampedro-Gómez Jesús , Sánchez-Puente Antonio , Vicente-Palacios Víctor , Dorado-Díaz P. Ignacio , Sánchez Pedro L.
Published: October 2022

Machine Learning allows facing complex tasks related to data analysis with big datasets. This Artificial Intelligence branch allows not technical contexts to get benefits related to data processing and analysis. In particular, in medicine, medical professionals are increasingly interested in Machine Learning to identify patterns in clinical cases and make predictions regarding health issues. However, many do not have the necessary programming or technological skills to perform these tasks. Many different tools focus on developing Machine Learning pipelines, from libraries for developers and data scientists to visual tools for experts or platforms to learn. However, we have identified some requirements in the medical context that raise the need to create a customized platform adapted to end-user found in this context. This work describes the design process and the first version of KoopaML, an ML platform to bridge the data science gaps of physicians while automatizing Machine Learning pipelines. The platform is focused on enhanced interactivity to improve the engagement of physicians while still providing all the benefits derived from the introduction of Machine Learning pipelines in medical departments, as well as integrated ongoing training during the use of the tool’s features.
Max Weber und die polnische Frage (1892–1920)
Authors: Konno Hajime
Published: October 2022

Hin- und her gerissen zwischen Polenfreundschaft und -feindschaft, engagierte sich Max Weber lebenslang und durchaus leidenschaftlich in der polnischen Frage. Nachdem ihn die Furcht vor unkontrollierter Einwanderung polnischer Wanderarbeiter zur Mitgliedschaft beim Alldeutschen Verband motiviert hatte, trat er nach 1905/06 plötzlich als Befürworter polnisch-kultureller Autonomie in Deutschland auf. Noch während des Ersten Weltkriegs einer derer, denen ernstlich um eine Verständigung zwischen Deutschland und Polen zu tun war, lehnte er nach dem Krieg die Abtretung der preußischen Ostprovinzen an den neuen polnischen Staat dezidiert ab und stellte sich gegen die polnische Einwanderung in Oberschlesien.

Auf der Basis neuer Archivarbeit geht dieses Buch den Gründen dafür nach und sucht diese systematisch zu erhellen. Darüber hinaus wirft es einen Blick auf Webers Schüler, den Ostmarkenpolitiker Leo Wegener.
Satellite ground segment :
Authors: Lightman Suzanne , Suloway Theresa , Brule Joseph
Published: October 2022

Space operations are increasingly important to the national and economic security of the United States. Commercial space's contribution to the critical infrastructure is growing in both volume and diversity of services as illustrated by the increased use of commercial communications satellite (COMSAT) bandwidth, purchase of commercial imagery, and the hosting of government payloads on commercial satellites. The U.S. government recognizes and supports space resilience as illustrated by numerous space policies, executive orders, and the National Cyber Strategy. The space cyber-ecosystem is an inherently risky, high-cost, and often inaccessible environment consisting of distinct yet interdependent segments. This report applies the NIST Cybersecurity Framework to the ground segment of space operations with an emphasis on the command and control of satellite buses and payloads.
Kierunki zmian ludnościowych w największych miastach Polski w latach 1980‑2020 = Directions of population change in the largest Polish cities, 1980‑2020
Authors: Szmytkie Robert
Published: October 2022

The main objective of the work detailed here was to identify the directions taken by changes in population in Poland’s largest cities over the years 1980-2020. The six cities involved are Warsaw, Kraków, Łódź, Wrocław, Poznań and Gdańsk, and it was at the turn of the 20th and 21st centuries that their situations as regards population diverged markedly, in turn under the influence of changing socio-economic conditions. Until the mid-1980s, the cities analysed followed similar trends for population. However, a period of demographic reconstruction then ensued, at that led to the aforementioned diversification. The current trends for population change result from one or other specific factor prevailing. In the case of the cities experiencing steady population growth, this is a positive migration balance, while in Łódź natural decrease prevails, and in Poznań a negative migration balance. In Poland’s 'Big Five' cities, population shares are in each case higher than elsewhere in the 0-4, 30-44 and 65+ age groups. Against this background, Łódź stands out as experiencing the clearest process of population ageing.
„Rewaloryzacja” centrum miasta: tendencje lokalizacyjne przedsiębiorstw technologicznych w skali mikro na przykładzie Warszawy = “Revalorisation” of the city centre: location trends among micro scale technology companies as exemplified by Warsaw
Authors: Smętkowski Maciej
Published: October 2022

The main objective of the paper was to analyse the spatial distribution of technology companies in the city, as well as to identify factors influencing their location. Warsaw, which can be treated as a metropolis with a relatively well-developed startup ecosystem, was used as an example of the changes occurring in urban space as a result of the fourth technological revolution. The analyses showed that entities involved in the production and implementation of new technological solutions located their activities more often in the central part of the city than in the peripheral districts. Among the important factors for their location were first of all the features of the building, including in particular the availability of coworking space offered in modern office buildings. However, residential buildings as well as older office buildings were also popular. This may indicate that technology companies - often start-ups - are looking for locations with lower space rental costs, but providing appropriate urbanisation benefits related to, for example, catering (cafes) and good transport accessibility, in particular proximity to metro station. On the other hand, agglomeration effects related to proximity to customers were not local but city-wide. Similarly, the accessibility of an airport did not significantly affect the location preferences of Warsaw's technology companies.
Rozwój sieci szlaków pieszych w Górach Sowich po II wojnie światowej = Development of the hiking-trail network in Poland’s Sowie Mountains since the Second World War
Authors: Kołodziejczyk Krzysztof
Published: October 2022

Since 2014, there has been a rapid development of the network of hiking trails in the Sowie Mountains, being part of the processes taking place in various parts of the Sudeten Mountains, especially in the Central Sudeten. These changes were analysed using i.a. graph analysis. The changes in the degree of development and coherence of the hiking trail network after World War II were determined and the reasons for marking new routes were examined, taking into account the tourist attractiveness of the area and the role these sections play in the network. The length of hiking trails in the Sowie Mountains in 2022 compared to 2005 almost doubled, with an approximate threefold increase in the number of nodes and sections between them. As a result the coherence of the network slightly decreased, but the possibilities of organising trips have clearly improved. There are many positive aspects of the development of the trail network in the Sowie Mountains. The new routes are related to the sightseeing values, they refer to the location of public transport stops, but also parking lots at the foot of the mountains and at the passes. There is a clear tendency to reduce the share of the asphalt surface.
L’artificialització del litoral valencià després de trenta-set anys (1985-2022)
Authors: Rosselló i Verger Vicenç M.
Published: October 2022

Els anys escolats després de les modificacions antròpiques del litoral s’han caracteritzat per l’incrementdels ports comercials i esportius i les repercussions del corrent de deriva litoral. Les causes fonamentalssón la fallida de la sedimentació, l’augment del nivell marí i l’edificació de la vorera immediata, afavoridaper l’especulació, els espigons de defensa i els “passeigs marítims” que no deixen més que indemnes elssectors de penya-segats.
Sants i cavallers, i també pagesos: herois literaris dels paisatges medievals
Authors: Garcia-Oliver Ferran
Published: October 2022

Durant els mil anys de duració de l’edat mitjana les imatges del paisatge evolucionen al ritme delcreixement –o el decreixement– econòmic i de les condicions mediambientals, però també en funciódels canvis operats en el sistema de valors. La natura salvatge, el bosc i els animals assumeixen papersi funcions distintes amb el pas dels segles. Aquest és l’objectiu del present article: detectar a través deles fonts literàries l’evolució i les modificacions en la percepció del paisatge de l’Occident medieval.
L’evolució del paisatge en les hortes valencianes i les estratègies productives subjacents (segles xvi-xix)
Authors: Peris Albentosa Tomàs
Published: October 2022

El paisatge de les hortes evolucionà força durant l’Antic Règim. De bon començament, la superfícieregada augmentà considerablement de resultes d’ampliar vells sistemes hidràulics medievals –donant comresultat hortes més compactes– i crear-se’n de nous. El canvi més remarcable fou, però, la intensificacióagrícola aconseguida amb la difusió de conreus ja coneguts en època medieval (entre els quals sobresurtenla morera i l’arròs) o arribats d’Amèrica, com dacsa i fesols. Es configurà així un nou paisatge de vol i sòl,que combinava un arbrat de moreres i fruiters espars o alineats en els llindes dels camps amb diversessembradures, entre les quals els cereals –blat, dacsa i arròs– sempre mantingueren un paper hegemònicque no seria assenyat interpretar com símptoma d’endarreriment.
La consolidació d’unes rotacions diversificades i molt productives per superfície cal relacionar-laamb: a) novetats en els mecanismes operatius fets servir per prorratejar cabal i d’altres canvis que experimentarenles entitats que agrupaven als regants; b) les estratègies productives i reproductives aplicadesen les petites explotacions camperoles.
Aquestes unitats familiars cada vegada estigueren més orientades cap a la intensificació i la diversificació,aconseguides gràcies a poder regar amb regularitat. Ambdós components –rotacions intensivesi diversificació productiva– atenuaren l’impacte dels riscs naturals i els efectes negatius de l’especulaciócomercial i les subdivisions hereditàries. Propiciaren la supervivència d’explotacions agrícoles cada copmés menudes en les quals la comercialització de collites i l’arrendament de terres acompliren un papercada vegada més rellevant.
De l’Alcalatén medieval a l’actual; evolució d’un paisatge
Authors: Escrig Fortanete Joaquim
Published: October 2022

L’Alcalatén és una comarca valenciana situada a la muntanya interior castellonenca que, al llarg
dels huit segles que abraça aquest estudi, ha experimentat un seguit de canvis de tota mena que hanconfigurat diversos tipus de paisatge; des del ramader dels primers segles i l’agrícola del xix i part delxx, fins la diversificació paisatgística actual que ha conformat tres tipus ben diferents de paisatge dinsla mateixa comarca.
En aquest article es tracta d’explicar el com i el per què de la seua evolució paisatgística; una evolucióque val, en gran mesura, per a entendre la general de les terres interiors castellonenques i ser conscientsde la situació d’aquestes en moments, com els actuals, de múltiples incerteses.
El recrecimiento de la presa de Almansa a finales del siglo XVIII y el plano de Bartolomé Rivelles
Authors: Giménez Font Pablo , Pardo Nàcher Cristian , Pereda Hernández Miguel Juan
Published: October 2022

La presa de Almansa, finalizada en 1586, está considerada como el más antiguo de los embalsesmodernos europeos, siendo precursora, por su planta en arco y dimensiones, del resto de los pantanosconstruidos durante los siglos xvi y xvii en España. En la segunda mitad del siglo xviii, sus 12,5 m dealtura inicial fueron ampliados hasta los 23,44 m actuales, principalmente gracias al proyecto y direccióndel arquitecto Bartolomé Rivelles, miembro destacado de las reales academias de San Fernando(Madrid) y San Carlos (Valencia). En el presente artículo se pretende analizar el proceso de gestaciónde las obras de recrecimiento de 1788, junto con el papel del arquitecto Rivelles y los detalles técnicosde su proyecto, con especial mención de los planos, hasta ahora inéditos. Las conclusiones intentandemostrar que el recrecimiento de la presa de Almansa resultó uno de los capítulos más exitosos de lahistoria hidráulica española del siglo xviii.
Aproximación al análisis del tiempo base y distribución espacial de los episodios de crecida del río Alfambra (Cuenca del Turia)
Authors: Sánchez Fabre Miguel , Ollero Ojeda Alfredo , Ballarín Ferrer Daniel
Published: October 2022

Los datos históricos aportados por los Anuarios de Aforo permiten apreciar un contraste muy acentuadoentre los elevados caudales máximos instantáneos registrados en diferentes episodios de crecidadel río Alfambra y los valores de caudal medio diario correspondientes a la jornada en que se alcanzaese máximo instantáneo. Ello lleva a pensar que algunas de las crecidas de este río se desarrollan enun tiempo muy breve, de escasas horas. La incorporación desde 1990 de los datos del SAIH-Júcar, conuna desagregación temporal mayor a la diaria (horaria, cincominutal), permite estudiar con detallela “duración real” de esos eventos de crecida. Además, la existencia de dos estaciones de aforo haceposible apreciar si todas las crecidas afectan siempre al conjunto de la cuenca o algunas de ellas quedanrestringidas a un sector de esta. El análisis de la serie temporal de registros en ambas estaciones permiteconstatar ambas hipótesis: diversas crecidas solo afectan a un sector de la cuenca y con elevada frecuencialas crecidas del río Alfambra tienen una duración tan breve que el dato de caudal medio diario no plasmaadecuadamente la magnitud del evento de crecida. En consecuencia, los datos del SAIH-Júcar, con mayor desagregación temporal, son imprescindibles para conocer de manera más fiel y real la evolución de las crecidas del río Alfambra.
La connexió entre Benali i la Vall de Càrcer, una altra possibilitat d’ús complementari del territori al segle XVI
Authors: Pérez Borredà Josep Rafael
Published: October 2022

Durant l’Edat Moderna es va consolidar una agricultura intensiva, d’alt potencial demogràfic ielevat diferencial productiu en les planes litorals valencianes, de manera que existia un cert desequilibrientre les terres de cultiu i de past, que plantejava com a resposta el repte de la complementarietatentre territoris a escala regional. Indicis d’aquesta acció complementària als territoris sembla que es vaproduir entre la Serra d’Énguera i algunes hortes de la Ribera, incloses en el terme de Xàtiva, cas de laVall Farta o Vall de Càrcer. En aquest treball s’explica un cas, a partir de la documentació conservadaen l’Arxiu Històric Nacional, que suggereix la pràctica de la complementarietat entre territoris a escalaregional en València durant l’Edat Moderna, en concret, el mantingut entre àrees amb vocació ramadera,la muntanya d’Énguera, i d’agricultura intensiva de regadiu, la Vall de Càrcer, a la Ribera del Xúquer.El fet que des de Càrcer i de Sumacàrcer es fera un ús pecuari de la Serra d’Énguera, s’entén tant pelprogrés agrari i demogràfic del Cinc-cents, que va empentar la ramaderia de les hortes a l’ermàs, comper la continuïtat d’un model anterior, encara que fortament condicionat i degradat, d’ús del territori,degut a la permanència de població morisca.
El rebost de la ciutat. Canvis als conreus de l’horta de València, 1850-1930
Authors: Calatayud Salvador
Published: October 2022

L’article estudia els canvis en la producció agrícola de l’Horta de València, una de les més extensesi productives de la Mediterrània en l’època. Al llarg de la segona meitat del segle xix y el primer terçdel xx, els conreus i les rotacions predominants des de temps enrere anaren deixant pas a un nou modelproductiu. El canvi principal va consistir en la desaparició relativament ràpida de conreus com lesmoreres i el cànem, centrals en l’agricultura tradicional de l’horta, junt al blat. Aquestes fibres tèxtilsvan ser desplaçades per l’auge de la producció d’hortalisses, patates i cebes, mentre es mantenia elconreu del blat a causa dels seus elevats rendiments. Aquest canvi responia a les transformacions de lademanda d’aliments i al creixement demogràfic de la ciutat de València, que constituïa un mercat enexpansió. Però, a diferència d’altres àrees de regadiu proveïdores de mercats urbans, com és el cas delBaix Llobregat i la ciutat de Barcelona, l’Horta de València va desenvolupar també línies productivesorientades a l’exportació. Cebes, patates i tomaques, sobretot, trobaren eixides importants en els mercatsnord-americà i britànic, fins arribar a xifres d’exportació molt elevades. Mentre, la major part d’hortalisseses venien a la ciutat contigua. Al capdavall, el nou model agrari es caracteritzava per la diversificacióde productes, la complexitat de les noves rotacions i la renovació de conreus en funció de les diferentsdemandes internes i externes.
El poblament dispers en la diòcesi de València segons la relació de 1791 manada recopilar per l’arquebisbe Fabián y Fuero
Authors: Torres Faus Francesc
Published: October 2022

El 1791, l’arquebisbe Fabián i Fuero va manar recopilar una relació de tota la informació estadísticai geogràfica de tipus eclesiàstic de la diòcesi de València, per al Nomenclàtor Eclesiàstic que preteniapublicar Floridablanca, Secretari d’Estat, completant el Cens de 1787 i el Nomenclàtor de 1789. Aquestno es va publicar, però la recopilació aporta una informació eclesiàstica i geogràfica inestimable. Es fa unasíntesi de l’evolució del poblament dispers valencià des de l’època medieval i, posteriorment, s’estudia elpoblament dispers el 1791. Es pot veure com al segle xviii es produeix un increment molt important dela població, cosa que provoca un creixement del poblament dispers que es distribuïa de manera desigual.A les zones de regadiu es concentrava a l’Horta de València i l’entorn de les principals ciutats i viles delRegne de València, com Xàtiva, Gandia, Dénia i la Vila Joiosa. Al secà trobem dues zones on és predominant,les comarques valencianes septentrionals al nord del riu Millars, i les comarques meridionalsal sud de Xàtiva i les muntanyes del Caroig, com són la Vall d’Albaida, la Muntanya i la Marina Baixa.
La construcción del paisaje rural de secano durante el proceso de colonización feudal del siglo XIII en el Reino de Valencia. El caso de Catí (Els Ports-Maestrat)
Authors: Esquilache Ferran , Guinot Enric
Published: October 2022

Durante el proceso de colonización que siguió a la conquista del Reino de Valencia en el siglo xiii,se transformó radicalmente el paisaje andalusí. En muchos lugares se construyeron parcelarios extensosmuy regulares para entregar a los colonos, pero en otros no fue así. En este trabajo se realiza un análisisde la geografía física y agraria del municipio de Catí, de la morfología catastral del núcleo de población,y de la red de caminos y de la morfología de los parcelarios agrarios, combinado todo ello con el usode una documentación excepcional que recoge el reparto de tierras realizado durante la colonización.Así llegamos a la conclusión de que en Catí se encajó entre la red de caminos y barrancos un nuevoparcelario regular en diversas tramas diferentes, y que las donaciones de parcelas a los colonos fueron desiguales en superficie y en cantidad porque se adaptaban al terreno, aunque el tamaño final de sus heredades acabase siendo el mismo.
Els parcel·laris medievals del secà al terme municipal de Castelló de la Plana (la Plana Alta)
Authors: Arasa i Gil Ferran
Published: October 2022

En els terrenys de secà del terme municipal de Castelló de la Plana, situats al nord i oest de la ciutat,es conserven tres parcel·laris formats per una sèrie de camins paral·lels situats a intervals pròxims quees coneixen com a “quadres”. Tot i que foren considerats inicialment com una possible centuriacióromana, la documentació coneguda permet datar-los a principis del segle xiv. La seua gran extensiófa que puguen considerar-se com els més importants fins ara estudiats entre els parcel·laris medievalsvalencians. Per les mateixes raons, aquestes intervencions realitzades amb l’objectiu d’ordenar l’espaiagrari d’una manera regular, han deixat una empremta perdurable en el paisatge rural d’aquesta ciutat,avui malauradament desfigurat per importants transformacions urbanístiques.
Una riqueza encerrada. Les carreteres en la formació de la província de Castelló (1833-1868)
Authors: Ferri Ramírez Marc
Published: October 2022

En el segle xix, es consolida a Europa el mite de les infraestructures. La inversió en obres públiques espresentava com la base per al desenvolupament econòmic, el que justifica una creixent inversió estatal encarreteres i ferrocarrils per posar en circulació les riques produccions de les regions poc comunicades. Enel context de la província de Castelló, la primera Guerra Carlina a més popularitzà la imatge del Maestratcom un territori rebel i especialment endarrerit que, amb l’apertura de la carretera del Maestrat rebriaun impuls civilitzador. Per sota dels discursos oficials, però, predominaven els interessos administratiusi la concepció de les autoritats provincials de que calia reforçar la capitalitat de Castelló de la Planaconvertint-la en centre d’una xarxa radial de carreteres d’àmbit provincial. El present article revisa elsprojectes de carreteres de l’etapa de les regències i el regnat d’Isabel II (1833-1868), els discursos queels justificaven i el seu context.
CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice
Authors: Moore-Fried Jamie , Paul Mahinder , Jing Zhixin , Fooksman David , Lauvau Gregoire
Published: October 2022

Plasmacytoid dendritic cells (pDCs) are the most potent producer of type I interferon (IFN), but how pDC is primed in vivo is poorly defined. Using a mouse model of severe malaria, we have previously established that upon priming by CD169+ macrophages (MPs), pDC initiates type I IFN-I secretion in the bone marrow (BM) of infected mice via cell-intrinsic TLR7 sensing and cell-extrinsic STING sensing. Herein we show that CD169+ MP and TLR7 sensing are both required for pDC arrest during priming, suggesting CD169+ MP are the source of TLR7 ligands. We establish that TLR7 sensing in pDC and chemotaxis are both required for pDC arrest and functional communication with CD169+ MP in the BM. Lastly, we demonstrate that STING sensing in CD169+ MP control pDC initiation of type I IFN production while also regulating pDC clustering and retention/egress from the BM. Collectively, these results link pDC acquisition of type I IFN-secreting capacity with changes in their motility, homing and interactions with CD169+ MP during infection. Thus, targeting this cellular interaction may help modulate type I IFN to improve outcomes of microbial infections and autoimmune diseases.
Screening and identification of miRNAs regulating Tbx4/5 genes of Pampus argenteus
Authors: Zhang Cheng , Zhang Shun , Liu Mengdi , Wang Yajun , Wang Danli , Xu Shanliang
Published: October 2022

Background

Silver pomfret (Pampus argenteus) is one of the most widely distributed and economically important pelagic fish species. However, an unique morphological feature of P. argenteus is the loss of pelvic fins, which can increase the energy requirement during food capture to some extent and is therefore not conducive to artificial culture. Tbx4/5 genes are highly conserved regulatory factors that regulate limb development in vertebrates and are in turn regulated by microRNAs (miRNAs). However, the miRNAs that directly regulate the Tbx4/5 genes in P. argenteus remain to be elucidated.

Methods

The Tbx4/5 genes of P. argenteus were first cloned, and the small RNA transcriptomes were sequenced by high-throughput sequencing during the critical period of the fin development at days 1, 7, and 13 of hatching. The miRNAs regulating the Tbx4/5 genes of P. argenteus were subsequently predicted by bioinformatics analysis, and the related miRNAs were verified in vitro using a dual fluorescence reporter system.

Results

A total of 662 miRNAs were identified, of which 257 were known miRNAs and 405 were novel miRNAs were identified. Compared to day 1, 182 miRNAs were differentially expressed (DE) on day 7, of which 77 and 105 miRNAs were downregulated and upregulated, respectively, while 278 miRNAs were DE on day 13, of which 136 and 142 miRNAs were downregulated and upregulated, respectively. Compared to day 13, four miRNAs were DE on day 7, of which three miRNAs were downregulated and one miRNA was upregulated. The results of hierarchical clustering of the miRNAs revealed that the DE genes were inversely expressed between days 1 and 7, and between days 1 and 13 of larval development, indicating that the larvae were in the peak stage of differentiation. However, the number of DE genes between days 7 and 13 of larval development was relatively small, suggesting the initiation of development. The potential target genes of the DE miRNAs were subsequently predicted, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of target genes were performed. The results suggested that the DE miRNAs were involved in growth, development, and signal transduction pathways, of which the Wnt and Fgfs signaling pathways are known to play important roles in the growth and development of fins. The results of dual fluorescence reporter assays demonstrated that miR-102, miR-301c, and miR-589 had a significant negative regulatory effect on the 3′-UTR of the Tbx4 gene, while miR-187, miR-201, miR-219, and miR-460 had a significant negative regulatory effect on the 3′-UTR of the Tbx5 gene. Altogether, the findings indicated that miRNAs play an important role in regulating the growth and development of pelvic fins in P. argenteus. This study provides a reference for elucidating the interactions between the miRNAs and target genes of P. argenteus in future studies.
Assessment on the Integration of the Basic Education Department of Notre Dame of Marbel University: Input for Strategic Management Plan
Authors: Friales Wilter , Sumadic Allan , Rosali Leann Jester
Published: October 2022

The term integration refers to merging the Elementary and High School Departments. The merging entailed alignment of the curriculum and management system from kindergarten to the secondary levels, where there is a unified set of administrative teams for both elementary and high school to plan, implement, monitor, and evaluate the curriculum and other administrative components. Using a descriptive research design, this study assessed the implementation of the integrated system of basic education at Notre Dame of Marbel University. Specifically, this study has determined the level of satisfaction of the personnel and retirees on the implementation of the integrated system of the basic education department of Notre Dame of Marbel University; and determining the strengths and weaknesses of the implementation of the integrated system as perceived by the personnel and retirees of NDMU-IBED. The result of the study reveals that all the areas being assessed, such as the Organizational Structure, Academic/Instructional Management, Program Implementation Scheme, Human Relationship, Leadership, and Participation, have obtained very satisfactory results. Strengths and Weaknesses were also identified in each of the areas mentioned. It can be concluded that the integrated system being implemented in the basic education of Notre Dame of Marbel University has brought more positive changes in terms of the organizational structure, academic management, program implementation monitoring scheme, human resource relationship, leadership, and participation.
School Responsiveness and Psychosocial Stability of Teachers, Parents, and Learners on the Implementation of Learning Delivery Modalities (LDMs): A Basis in Policy Brief Formulation
Authors: Oribiana Susan , Palanas Dexter , Fuego Ligaya
Published: October 2022

Pedagogy, technology, and material resources are some challenges in ensuring the continuity of learning, while teachers, parents, and learners are factors that significantly affect the school’s learning performance. The Department of Education mandate schools and learning centers to implement capacity building and establish support mechanism to ensure the seamless transition of learning activities into the New Normal. The objective of the study is to understand how parents, learners, and teachers will be able to adjust to the new learning setup, embrace the changes, and affects the delivery and acquisition of new learning, as well as the implications of the pandemic in the participant’s personality. A sequential explanatory research design was used in the study. Data were collected in two consecutive phases. First phase data were computed from the responses in the survey questionnaire, while the second phase responses from focus group discussion used thematic analysis. Based on the generated themes, a new intervention model, Three-way Teaching and Learning Process in the New Normal, was established. The model integrates significant processes such as observation, communication, instruction, interaction, support, and participation in ensuring the success of the new learning set-up. The model also shows interventions highlighted, such as communication access, professional development, digital collaboration, independent learning, stakeholder engagement, and parental education. The intervention model is recommended to be used as an implementation framework in the Division and School Learning Continuity Plan.
The End of Anonymous Sperm Donation in Colorado
Authors: Cohen I. Glenn , Adashi Eli Y. , Mohapatra Seema
Published: October 2022

This Viewpoint discusses the new Colorado law prohibiting anonymous gamete donation and other debates over reproductive technologies and secrecy.
Experiences With Prenatal Care Delivery Reported by Black Patients With Low Income and by Health Care Workers in the US
Authors: Peahl Alex Friedman , Moniz Michelle H. , Heisler Michele , Doshi Aalap , Daniels Gwendolyn , Caldwell Martina , Dalton Vanessa K. , De Roo Ana , Byrnes Mary
Published: October 2022

Importance

Black pregnant people with low income face inequities in health care access and outcomes in the US, yet their voices have been largely absent from redesigning prenatal care.

Objective

To examine patients’ and health care workers’ experiences with prenatal care delivery in a largely low-income Black population to inform care innovations to improve care coordination, access, quality, and outcomes.

Design, Setting, and Participants

For this qualitative study, human-centered design–informed interviews were conducted at prenatal care clinics with 19 low-income Black patients who were currently pregnant or up to 1 year post partum and 19 health care workers (eg, physicians, nurses, and community health workers) in Detroit, Michigan, between October 14, 2019, and February 7, 2020. Questions focused on 2 human-centered design phases: observation (understanding problems from the end user’s perspective) and ideation (generating novel potential solutions). Questions targeted participants’ experiences with the 3 goals of prenatal care: medical care, anticipatory guidance, and social support. An eclectic analytic strategy, including inductive thematic analysis and matrix coding, was used to identify promising strategies for prenatal care redesign.

Main Outcomes and Measures

Preferences for prenatal care redesign.

Results

Nineteen Black patients (mean [SD] age, 28.4 [5.9] years; 19 [100%] female; and 17 [89.5%] with public insurance) and 17 of 19 health care workers (mean [SD] age, 47.9 [15.7] years; 15 female [88.2%]; and 13 [76.5%] Black) completed the surveys. A range of health care workers were included (eg, physicians, doulas, and social workers). Although all affirmed the 3 prenatal care goals, participants reported failures and potential solutions for each area of prenatal care delivery. Themes also emerged in 2 cross-cutting areas: practitioners and care infrastructure. Participants reported that, ideally, care structure would enable strong ongoing relationships between patients and practitioners. Practitioners would coordinate all prenatal services, not just medical care. Finally, care would be tailored to individual patients by using care navigators, flexible models, and colocation of services to reduce barriers.

Conclusions and Relevance

In this qualitative study of low-income, Black pregnant people in Detroit, Michigan, and the health care workers who care for them, prenatal care delivery failed to meet many patients’ needs. Participants reported that an ideal care delivery model would include comprehensive, integrated services across the health care system, expanding beyond medical care to also include patients’ social needs and preferences.
Frequency and Underlying Pathology of Pure Vascular Cognitive Impairment
Authors: Oveisgharan Shahram , Dawe Robert J. , Yu Lei , Kapasi Alifiya , Arfanakis Konstantinos , Hachinski Vladimir , Schneider Julie A. , Bennett David A.
Published: October 2022

Importance

It is not clear how common pure vascular cognitive impairment (VCI) is in the absence of Alzheimer disease (AD) and/or other neurodegenerative pathologies.

Objective

To identify participants without AD and other neurodegenerative pathologies and determine the extent to which cerebrovascular disease pathologies were associated with cognitive impairment.

Design, Setting, and Participants

This clinical pathological study included participants from 2 ongoing community-based cohorts that began enrollment in 1994 and 1997. Prior to death, participants were observed for a mean (SD) of 8.4 (5.3) years with annual assessments. From 2096 participants who died, 1799 (85.8%) underwent autopsy and 1767 had complete postmortem pathological examination data at the time of data analyses. To identify participants without neurodegenerative pathologies, we categorized them in 3 subgroups. A vascular subgroup was composed of participants without significant levels of neurodegenerative brain pathologies. A neurodegenerative subgroup was composed of participants without significant levels of cerebrovascular disease pathologies. A mixed subgroup was composed of the rest of the participants. Data were analyzed from May 2021 to July 2022.

Exposures

Brain pathology indices obtained by postmortem pathological assessments.

Main Outcomes and Measures

The primary outcome was cognitive impairment defined by presence of mild cognitive impairment or dementia. The secondary outcome was cognition assessed by 19 neuropsychological tests.

Results

Of 1767 included participants, 1189 (67.3%) were women, and the mean (SD) age at death was 89.4 (6.6) years. In the vascular subgroup (n = 369), cognitive impairment was present in 156 participants (42.3%) and was associated with cerebrovascular disease pathologies (macroinfarcts: odds ratio [OR], 2.05; 95% CI, 1.49-2.82; P < .001; arteriolosclerosis in basal ganglia: OR, 1.35; 95% CI, 1.04-1.76; P = .03) but not AD or other neurodegenerative pathologies, an indication of pure VCI. In mixed-effects models including all the pathologies, only macroinfarcts were associated with a faster cognitive decline rate (estimate, −0.019; SE, 0.005; P < .001) in the vascular subgroup. Further analyses identified macroinfarcts in the frontal white matter to be associated with faster cognitive decline rate when macroinfarcts of cortical and subcortical brain regions were examined in a single model.

Conclusions and Relevance

In this study, pure VCI was not rare. Macroinfarcts, specifically in frontal white matter, were the main cerebrovascular disease pathologies associated with cognitive decline in pure VCI.
Ion−π interactions for constructing organic luminescent materials
Authors: Jiang Guoyu , Yu Jia , Wang Jianguo , Tang Ben Zhong
Published: October 2022

Organic luminescent materials are one of the research hotspots worldwide. The luminescent efficiency of these materials can be tuned by introducing noncovalent interactions. Ion−π interactions, mainly including anion−π interactions and cation−π interactions, are relatively new but powerful noncovalent interactions with extensive applications in supramolecular chemistry. The use of ion−π interactions to fabricate highly luminescent materials is initiated since they were introduced to develop aggregation‐induced emission luminogens in 2017. Then, this research field is undergoing through challenging but very prospective developments. In this minireview, we start with a brief introduction of ion−π interactions and then make a summary of the reports on organic fluorescence based on ion−π interactions and room temperature phosphorescence induced by ion−π interactions. The applications of organic luminescent materials based on ion−π interactions in bioimaging, imaging‐guided anticancer and antibacterial treatment are also discussed. The challenges and prospects of using anion−π and cation−π interactions for constructing organic luminogens are presented in the final part. It is expected that this minireview will provide some guidelines for fabricating novel organic luminescent materials and further extend the application potential of ion−π interactions.
Advancing MXene Electrocatalysts for Energy Conversion Reactions: Surface, Stoichiometry, and Stability
Authors: Tsounis Constantine , Kumar Priyank V. , Masood Hassan , Kulkarni Rutvij Pankaj , Gautam Gopalakrishnan Sai , Müller Christoph R. , Amal Rose , Kuznetsov Denis A.
Published: October 2022

MXenes, due to their tailorable chemistry and favourable physical properties, have great promise in electrocatalytic energy conversion reactions. To exploit fully their enormous potential, further advances specific to electrocatalysis revolving around their performance, stability, compositional discovery and synthesis are required. The most recent advances in these aspects are discussed in detail: surface functional and stoichiometric modifications which can improve performance, Pourbaix stability related to their electrocatalytic operating conditions, density functional theory and advances in machine learning for their discovery, and prospects in large scale synthesis and solution processing techniques to produce membrane electrode assemblies and integrated electrodes. This Review provides a perspective that is complemented by new density functional theory calculations which show how these recent advances in MXene material design are paving the way for effective electrocatalysts required for the transition to integrated renewable energy systems.
Regioselective synthesis ofβ‐hydroxy sulfides using aryl halides
Authors: Nowrouzi Najmeh , Abbasi Mohammad , Shaikhi Shahidzadeh Elham
Published: October 2022

Cyanodithioformate salt as an odorless and simply operational source of sulfur was reacted with aryl halides in the presence of copper iodide, affording diaryl disulfide, which reacted with styrenes/α‐methylstyrene in second step to formβ‐Hydroxy sulfides with high regioselectivity in good to excellent yields.
Relevance insensitivity: A framework of psychological biases in consumer behavior and beyond
Authors: Yang Yang , Li Xilin , Hsee Christopher K.
Published: October 2022

In judgment and choice, consumers show a variety of biases, from the sunk cost fallacy and projection bias to usage frequency neglect and erroneous price–quality inferences. This article explains these seemingly disparate biases and predicts new biases using an overarching framework based on the relevance insensitivity theory proposed by Hsee et al. (2019). According to the theory, many biases arise because people are insufficiently sensitive to the relevance (i.e., weight) of a cue variable to the target variable (the dependent variable). The direction of the bias depends on the normative relevance of the cue—people over‐rely on the cue when it is normatively irrelevant and under‐rely on the cue when it is normatively highly relevant. We show that ostensibly unique and universal biases are neither unique nor universal: All are manifestations of relevance insensitivity, and each bias attenuates or reverses as the cue variable's relevance changes.