bluuebunny/crossref_metadata_2025 huggingface dataset:
Research articles on volunteering in biomedical journals: a MEDLINE-based bibliometric analysis
Authors: Cheng Bo-Ren , Chang Hsiao-Ting , Lin Ming-Hwai , Chen Tzeng-Ji , Chou Li-Fang , Hwang Shinn-Jang
Published: February 2020

Objective

Volunteering, an important aspect of society, is a multidisciplinary issue. However, there few are extensive surveys examining the trend and scope of research on volunteering in biomedical areas.

Methods

Publications indexed with the Medical Subject Headings “volunteers” or “hospital volunteers” were downloaded from MEDLINE. We excluded publications indexed with “healthy volunteers” from the analysis.

Results

A total 3555 research articles on volunteering were found in 1283 journals, through the end of 2016. The number of publications increased gradually from 1 article in 1953 to 254 articles in 2016. Only 51 journals had published 10 or more articles on this topic. Research articles on volunteering were published in journals with 110 specialties and were most often in journals related to public health, nursing, and health services. The largest proportion of articles was related to psychology. Although 10,853 authors were identified in 3555 articles, only eight authors have published more than 10 research articles on volunteering.

Conclusion

Research interest in volunteering in biomedical areas has been growing in recent decades, but the total number of publications on volunteering remains relatively small.
Hepatic veno-occlusive disease may be a rare characteristic of hepatic involvement in systemic amyloidosis: case report and literature review
Authors: Zhu Tong-Yin , Zhou Guan-Hui , Chen Xin-Hua , Teng Xiao-Dong , Sun Jun-Hui
Published: February 2020

Systemic amyloidosis is a rare disease and patients with hepatic amyloidosis often present with hepatomegaly. Hepatomegaly can also be a feature of hepatic veno-occlusive disease (HVOD). We report here a case of systemic amyloidosis in a patient who was suspected of having HVOD. On the basis of computed tomography findings in the abdomen, HVOD was initially suspected in a 63-year-old man with the chief complaint of upper abdominal pain, ascites, and weight loss. Multiple patchy purpura and nerve symptoms were identified and these were due to amyloidosis. An increase in proteinuria and immunoglobulin κ light-chain levels, and thickening of the ventricular wall supported the diagnosis of systemic light-chain amyloidosis involving the liver, heart, kidney, skin, and nerves. This diagnosis was confirmed by histological examination of a bone marrow core biopsy with Congo red dye. Sequential treatment of bortezomib and dexamethasone led to good results in the patient. Findings of this rare case indicate that HVOD can be diagnosed without a definite history of hematopoietic stem cell transplantation or pyrrolizidine alkaloid ingestion, but more evidence is required to make an accurate diagnosis. Importantly, we speculate that HVOD is a rare characteristic of liver involvement in systemic amyloidosis.
Effectiveness of home-based preoperative pulmonary rehabilitation in COPD patients undergoing lung cancer resection
Authors: Rispoli Marco , Salvi Rosario , Cennamo Antonio , Di Natale Davide , Natale Giovanni , Meoli Ilernando , Gioia Maria Rosaria , Esposito Marianna , Nespoli Moana Rossella , De Finis Mario , Buono Salvatore , Corcione Antonio , Lavoretano Sabrina , Bianco Andrea , Fiorelli Alfonso , Curcio Carlo , Perrotta Fabio
Published: February 2020

Objective:

To investigate the effectiveness of a home-based preoperative rehabilitation program for improving preoperative lung function and surgical outcome of patients with chronic obstructive pulmonary disease (COPD) undergoing lobectomy for cancer.

Methods:

This was a prospective, observational, single-center study including 59 patients with mild COPD who underwent lobectomy for lung cancer. All patients attended a home-based preoperative rehabilitation program including a minimum of 3 sessions each week for 4 weeks. Each session included aerobic and anaerobic exercises. Participants recorded the frequency and the duration of exercise performed in a diary. The primary end point was to evaluate changes in lung function including predicted postoperative (PPO) forced expiratory volume in 1 second (FEV1), 6-minute walking distance test (6MWD), PPO diffusing capacity for carbon monoxide (DLCO) %, and blood gas analysis values before and after the rehabilitation program. Postoperative pulmonary complications were recorded and multivariable analysis was used to identify independent prognostic factors (secondary end point).

Results:

All patients completed the 4-week rehabilitation program. Thirteen of 59 (22%) patients (Group A) performed <3 sessions per week (mean sessions per week: 2.3±1.3); 46 of 59 (78%) patients (Group B) performed ⩾3 sessions per week (mean sessions per week: 3.5±1.6). The comparison of PPO FEV1% and 6MWD before and after rehabilitation showed a significant improvement only in Group B. No significant changes in PPO DLCO% or in blood gas analysis values were seen. Nine patients presented postoperative pulmonary complications, including atelectasis ( n = 6), pneumonia ( n = 1), respiratory failure ( n = 1), and pulmonary embolism ( n = 1). Group A presented higher number of postoperative pulmonary complications than Group B (6 vs 3; p = 0.0005). Multivariate analysis showed that the number of weekly rehabilitation sessions was the only independent predictive factor ( p = 0.001).

Conclusions:

Our simple and low-cost rehabilitation program could improve preoperative clinical function in patients with mild to moderate COPD undergoing lobectomy and reduce postoperative pulmonary complications. All patients should be motivated to complete at least 3 rehabilitation sessions per week in order to obtain significant clinical benefits. Our preliminary results should be confirmed by larger prospective studies.
Benefits of EEG-Neurofeedback on the Modulation of Impulsivity in a Sample of Cocaine and Heroin Long-Term Abstinent Inmates: A Pilot Study
Authors: Corominas-Roso M. , Ibern I. , Capdevila M. , Ramon R. , Roncero C. , Ramos-Quiroga J. A.
Published: February 2020

The aim of this pilot study was to assess whether neurofeedback (NFB) can be useful in the treatment of impulsive behavior in long-term abstinent cocaine and heroin addicts. A single-blind sham-controlled NFB protocol was carried out to assess the effects of NFB on impulsivity in 20 (10 + 10) cocaine and heroin long-term abstinent addicts ( Diagnostic and Statistical Manual of Mental Disorders [4th ed., text rev.; DSM-IV-TR]). Psychotic and neurologic diseases were excluded. Participants underwent 40 NFB sessions based on the very slow cortical potential range. Inhibitory deficits were specifically addressed through right and left prefrontal training. Clinical improvement was measured with Likert-type scales, the Hamilton Depression Rating Scale, and the State–Trait Anxiety Inventory, and impulsivity was assessed using the Barratt Impulsiveness Scale and the Continuous Performance Test. Although the results are preliminary due to the small sample size, the NFB-treated group showed a significant clinical improvement, including symptoms of anxiety and depression, with two differentiated time periods. No significant clinical improvement was found in the control group. A significant decrease in the post- versus pre-treatment measures of global impulsivity, nonplanning impulsivity, and error commission measures was found in the NFB-treated group; effect size ( dKorr) in the pre–post control design was moderate. No significant change was found in the control group. Despite the limitations of this study, the results suggest that NFB is better than placebo in improving impulsivity and clinical symptoms of anxiety and depression in long-term abstinent cocaine- and heroin-dependent individuals.
Fiber/matrix interface stress analysis of flax-fiber composites under transverse loading considering material nonlinearity
Authors: Sabuncuoglu Baris , Cakmakci Onur , Kadioglu Fevzi S
Published: February 2020

Distribution of stresses in fiber/matrix interface in UD flax fiber reinforced composites is investigated under transverse loading and compared with conventional synthetic fibers. Micro-scale finite element models with representative volume elements are generated with various fiber packing types and fiber volume ratios. The study is performed for various strain values, which take into account the material nonlinearity of matrix. The results show that significantly lower stress concentrations exist in the case of flax fibers compared to glass fiber composites, explaining the absence of transverse cracks until failure in previously conducted transverse tension tests. Increase in the applied transverse strain causes a further decrease in the stress concentrations due to the nonlinear behavior of the matrix.
Planning the optimal debris removal of destroyed buildings in the Midan region in the Old City of Mosul
Authors: Al-Jarjees Sarah D. , Al-Ahmady Kossay K.
Published: February 2020

After the liberation of the Old City in Mosul, the Midan region appears to be the most affected part of the Old City. In the current study, debris of the Midan region was studied in detail by defining the destroyed areas using geographic information systems (GIS), then calculating the volume and weight of the total debris. The ratio of each component of debris (building stones, gypsum and concrete) was also determined during the study. The results showed that the destruction was about 89.47% of the Midan total area. In addition, the study showed that the total volume of the debris in the Midan area is estimated at 0.73 million cubic meters, the residential buildings accounting for about 86.87% of the total volume of the debris. The total weight of debris is estimated at 1.2 million tons, of which 0.91 million tons are the ruins of old building materials (building stones, gypsum).

Finally, the optimal route for collecting the debris from the Midan region was found by utilizing ArcGIS network analyst extension, taking into account the archaeological sites in the study area, the proposed collection system assumed to have the benefits of minimizing collection time, distance travelled, man-effort and consequently financial and environmental costs. Total distance and accumulated time were illustrated in a table providing detailed information on the proposed route.
Planning an intersectoral network of healthcare and community leaders to advance trans-affirming care for sexual assault survivors
Authors: Saad Megan , Burley Joseph Friedman , Miljanovski Melissa , Macdonald Sheila , Bradley Chett , Du Mont Janice
Published: February 2020

Sexual assault against transgender (trans) persons is a complex public health issue requiring the coordinated effort of multiple sectors to address. In response to a global call to improve health equity for persons of diverse gender identities, leaders across health and social service sectors need to enhance collaboration to champion trans-affirming care for sexual assault survivors. In collaboration with Egale Canada Human Rights Trust and the Ontario Network of Sexual Assault/Domestic Violence Treatment Centres, we have undertaken the development of an intersectoral network to connect trans-positive community organizations with hospital-based violence treatment centres to improve support services for trans survivors across Ontario. Guided by the Lifecycle Model for network development outlined by the National Collaborating Centre for Methods and Tools, we describe our approach to planning the intersectoral network, including key insights learned thus far and the potential of the network moving forward.
Evaluation of Radiology Reports by the Emergency Department Clinical Providers: A Message to Radiologists
Authors: Abdellatif Waleed , Ding Jeffrey , Hussien Abdelmohsen Radwan , Hussain Ali , Shirzad Shahin , Ryan Max F. , O’Neill Siobhan B. , Forster Bruce B. , Nicolaou Savvas
Published: February 2020

Objectives:

This study is an evaluation of the emergency department (ED) satisfaction with the current radiologic reporting system used at a major Northeastern academic medical center. The radiology reports are the main form of communication and usually the final product of any radiological investigation delivered to clinicians. The aim of this study was to improve current radiology reporting practices and to better tailor reports to match the needs and expectations of ED clinicians.

Methods:

A 9-question online survey was sent to ED residents, fellows, faculty, and nurse practitioners/advanced practice providers at a major Northeastern academic medical center in the United States. For the open-ended section, coding and emergent theme categorization was conducted for quantification of responses. The survey was designed to evaluate the attitudes toward the structure, style, form, and wording used in reports.

Results:

The response rate was 48.6% (68/140). The ED respondents were generally satisfied with radiology reports, their language, vocabulary, and clarity. They preferred the impression section to be before the findings in simple examinations and to stratify the reports according to emergency status for complex examinations. They did not like extended differential, hedge terms, and delayed reporting. Additionally, ED respondents recommended focused, fast reporting with considerable changes toward a more standardized report.

Conclusions:

This evaluation delivered a list of actionable recommendations. The top recommendation is to standardize reporting structure, style, and lexicon, in addition to being focused, timely, and brief.
Technical viewpoint on polystyrene/graphene nanocomposite
Authors: Kausar Ayesha
Published: February 2020

This review presents state-of-the-art progress in the field of polystyrene (PS)/graphene nanocomposite. Graphene is a monoatomic thick nanoallotrope of carbon. It has attracted tremendous research consideration owing to chemical functionalization aptitude and remarkable physical properties. Graphene has been used as a potential nanofiller to dramatically improve the performance of polymeric nanocomposite. PS is an important synthetic aromatic thermoplastic polymer. Graphene has been used to enhance the mechanical strength, thermal stability, electrical conductivity, and thermal conductivity of PS/graphene nanocomposite. Dispersion routes and synthetic methods of graphene and PS/graphene nanocomposite have also been reviewed. PS/graphene nanocomposites have been explored for anticorrosion, electromagnetic interference shielding, batteries, electrocatalysis, and microextraction applications. In spite of interesting developments, a lot remains to be done with regard to fundamental understanding of structure–property relationship and designing materials to operate for advanced high performance applications. This review is also concluded listing current challenges associated with processing and future perspectives of nanocomposite.
Homocysteine, Vitamin B12, and Serum and Erythrocyte Folate in Peritoneal Dialysis and Hemodialysis Patients
Authors: De Vecchi Amedeo F. , Bamonti–Catena Fabrizia , Finazzi Silvia , Campolo Jonica , Taioli Emanuela , Novembrino Cristina , Colucci Patrizia , Accinni Roberto , De Franceschi Michela , Fasano Maria Antonietta , Maiolo Anna Teresa
Published: February 2020

Background

Plasma homocysteine (Hcy) is an independent risk factor for cardiovascular disease. High levels of plasma Hcy have been observed in end-stage renal disease patients. Few studies have compared peritoneal dialysis (PD) and hemodialysis (HD) patients and few data are available on erythrocyte folate (ery-F) levels in dialysis patients.

Objectives

To evaluate plasma Hcy concentrations, vitamin B12 (B12), and folate status in dialysis patients; to analyze the possible causes of high Hcy levels; to follow up changes in folate and B12 concentrations after 6 months.

Design

A cross-sectional observational study.

Setting

Nephrology division and laboratory of hematology in a university and clinical research hospital.

Patients

The study included 82 patients treated with PD for 37 ± 37 months and 70 patients treated with HD for 136 ± 95 months.

Laboratory Methods

Plasma Hcy was measured by the immunoenzymatic IMx Hcy FPIA method (Abbott Laboratories, Diagnostic Division, Abbott Park, IL, U.S.A.), serum folate (s-F) and ery-F by the Stratus folate fluorometric enzyme-linked assay, and B12 by the Stratus vitamin B12 fluorometric enzyme-linked assay (DADE-Behring, Newark, DE, U.S.A.).

Results

Ninety-six percent of PD and 97% of HD patients had Hcy levels above the cutoff (13.5 μmol/L). Homocysteine level was higher in HD than in PD patients, while the prevalence of hyperhomocysteinemia was similar with the two techniques. Erythrocyte folate was significantly higher in PD (1333 ± 519 pmol/L) than in HD (1049 ± 511 pmol/L, p < 0.01). Statistically significant correlations were observed between Hcy and B12, s-F, ery-F, and dialysis duration. Multivariate analysis showed a strong correlation between s-F and Hcy. After 6 months there were no differences in Hcy, B12, s-F, and ery-F levels.

Conclusions

Plasma Hcy levels were high in more than 95% of our dialysis patients, with no relation to the type of dialysis. Vitamin B12 and folate were normal in the majority of our patients. However, serum folate was the major determinant of Hcy levels. Such a relation between Hcy and folate suggests that levels of folate within the reference interval are inadequate for dialysis patients.
Clinical Outcomes of Immediate Full-Volume Exchange One Year after Peritoneal Catheter Implantation for CAPD
Authors: Song Joon Ho , Kim Gyeong A. , Lee Seoung Woo , Kim Moon-Jae
Published: February 2020

Objective

To evaluate actual risk of complications and 1-year catheter survival of immediate full-volume 2000-mL dialysate exchange after peritoneal catheter implantation.

Design and Setting

A prospective randomized comparative study in a university hospital kidney center.

Patients

The study included 59 end-stage renal disease patients entering into a continuous ambulatory peritoneal dialysis program between January 1996 and December 1997.

Interventions

In group 1 ( n = 21), exchange volume was gradually increased from 500 mL per 3 hours to full-volume exchange over 13 days. In group 2 ( n = 38), full-volume exchange per 6 hours was performed from the day of catheter implantation. Bed rest with minimal activity was recommended for the first 3 days in both groups.

Main Outcome Measures

Occurrence of catheter-related complications such as dialysate leakage, drainage failure, malposition, infectious complications, and, ultimately, catheter loss were observed for 1 year.

Results

After straight Tenckhoff catheter implantation, pericatheter dialysate leaks occurred in 9.5% of group 1 and in 10.5% of group 2 patients (no significance, NS). Within 1 month of implantation, the incidences of tunnel or exit-site infection, catheter malposition, and outflow failure were not significantly different between the two groups. Abdominal discomfort was noted in 2 patients from group 2. Peritonitis occurred in 9.5% and 5.3% (NS) within 2 weeks of catheter implantation, and in 14.3% and 10.5% (NS) after more than 2 weeks in group 1 and group 2, respectively. Early catheter loss within 1 month occurred in 4.8% of patients in group 1 and 5.3% in group 2 (NS). The causes of loss were persistent leakage in group 1, and persistent leakage combined with tunnel infection and outflow failure in group 2. The duration of hospitalization from the day of catheter insertion to discharge was definitely shorter in group 2 compared to group 1 (9.9 ± 0.6 days vs 15.0 ± 0.8 days, p < 0.001). For 1-year follow-up, the frequencies of peritonitis were 0.062 ± 0.015/patient-month in group 1 and 0.076 ± 0.018/patient-month in group 2 (NS). The actual 1-year catheter survival was 85.7% in group 1 and 84.2% in group 2 (NS).

Conclusions

One-year catheter survival after immediate full-volume peritoneal dialysis exchange was 84.2%. This study did not show any evidence that immediate full-volume exchange causes more short- or long-term complications compared to the stepwise volume increment method.
Recurrence of Hyperparathyroidism after Total Parathyroidectomy and Autotransplantation in Peritoneal Dialysis Patients
Authors: Zhong Aimin , Billa Viswanath , Rotstein Lorne E. , Wong Pui Y. , Bargman Joanne M. , Vas Stephen I. , Oreopoulos Dimitrios G.
Published: February 2020

Objective

To evaluate the effectiveness of total parathyroidectomy (PTX) with autotransplantation in the treatment of secondary hyperparathyroidism (HPT), and to assess recurrence rate of HPT in this peritoneal dialysis (PD) population.

Design

A retrospective study in a single home PD unit.

Patients

Between 1994 and 1998, 19 of 574 patients on PD underwent PTX for treatment of secondary HPT.

Main Outcome Measures

Clinical and biochemical improvement, recurrence of HPT, improvement in anemia post-PTX.

Results

Nineteen (3.3%) patients required PTX between 1994 and 1998. These 5 men and 14 women ranged in age from 22 to 66 years; they had been on maintenance PD pre-PTX for 47.5 ± 38.1 months, and were followed for 26.1 ± 15.5 months post-PTX. Sixteen patients had temporary hypocalcemia that was managed by oral (n = 10) or intravenous (n = 6) calcium supplements and calcitriol, while 3 patients had severe “hungry bone” syndrome postoperatively. One patient had recurrent laryngeal nerve palsy post-PTX. Bone pain disappeared in all 12 patients. Pruritus improved in 12/13 patients; fatigue improved in 15/16 patients. Comparison showed significant differences between hemoglobin and hematocrit values 1 month pre-PTX and 12 months post-PTX ( p < 0.05). Parathyroid hormone (PTH) level in 15 (79%) patients returned to normal (≤€7.6 pmol/L) during the first month post-PTX. In 5/12 (42%) patients, PTH level was ≤ 7.6 pmol/L 2 years post-PTX, while in 2/12 (17%), PTH was > 22.8 pmol/L (three times normal) 2 years post-PTX, and 3/5 (60%) patients had a PTH > 22.8 pmol/L 3 years post-PTX.

Conclusions

Total PTX with autotransplantation is associated with a tendency for recurrence of HPT. Our findings suggest that total PTX with autotransplantation may be an ineffective procedure in controlling HPT over the long term.
Protein-Losing Enteropathy is Associated with Peritoneal Functional Abnormalities in Peritoneal Dialysis Patients
Authors: Aguilera Abelardo , Bajo M. Auxiliadora , Codoceo Rosa , Mariano Mario , Del Peso Gloria , Olveira Antonio , Millán Isabel , Gómez–Cerezo Jorge , Selgas Rafael
Published: February 2020

Objective

To evaluate the relationship between acquired peritoneal transport disorders and the presence of protein-losing enteropathy (PLE), and their contribution to the protein malnutrition in peritoneal dialysis (PD) patients.

Patients and Methods

We studied 31 clinically stable PD patients that received a fat overload diet for 3 days. We measured intestinal absorption of fecal fat (normal < 6 g/24-hour stool) and nitrogen (normal < 2 g/24-hr stool), intestinal protein permeability [fecal clearance of α1-antitrypsin (Cα1AT) (normal < 12 mL/24-hr stool)], and nutritional markers [normalized protein nitrogen appearance (nPNA), half-life medium-term proteins, and body mass index]. Peritoneal solute transport was measured by mass transfer coefficient (MTC), and water transport by peritoneal ultrafiltration (UF) capacity. To define protein maldigestion it was necessary to find high fecal nitrogen values with normal Cα1AT; PLE was defined when both values were elevated.

Results

High fecal nitrogen (mean 2.1 ± 1 g/24-hr stool) and fat (mean 5.8 ± 3.6 g/24-hr stool) were found in 15 patients; 6 patients had high Cα1AT levels (PLE). These 6 patients showed a worse nutritional status: lower albumin (3.57 ± 0.57 g/dL vs 3.98 ± 0.38 g/dL, p < 0.05) and transferrin (243 ± 70 mg/dL vs 272 ± 44.3 mg/dL, p < 0.05), as well as lower triglycerides (131.3 ± 31.7 mg/dL vs 187 ± 116 mg/dL, p < 0.05). Higher urea MTCs were found in 10 patients, normal in 7, and lower in 14. Higher creatinine MTCs were found in 8 patients, normal in 15, and lower in 8. Normal peritoneal UF capacity was found in 25 and lower in 6 patients. These 6 patients showed higher urea and creatinine MTCs and Cα1AT. A positive linear correlation between Cα1AT, urea MTC ( r = 0.56, p < 0.01), and creatinine MTC ( r = 0.46, p < 0.01) was found. A similar situation occurred between Cα1AT, fecal fat ( r = 0.45, p < 0.05), and fecal nitrogen ( r = 0.43, p < 0.05). Thirteen patients with previous history of peritonitis showed higher Cα1AT than those without peritonitis (10.2 ± 8 mL/24-hr stool vs 5.2 ± 4.4 mL/24-hr stool, p < 0.05).

Conclusions

We confirm that protein and fat malabsorption, maldigestion, and PLE are present in some PD patients. Higher fecal Cα1AT is associated with malnutrition and poorer showings of the viability markers of peritoneal membrane function.
Intermediate Outcomes by Race and Ethnicity in Peritoneal Dialysis Patients: Results from the 1997 ESRD Core Indicators Project
Authors:   for the National ESRD Core Indicators Workgroup, Rocco Michael V. , Frankenfield Diane L. , Frederick Pamela R. , Pugh Jacqueline , McClellan William M. , Owen William F.
Published: February 2020

Background

Hispanics are the fastest growing minority group in the United States, and approximately 10% of all end-stage renal disease (ESRD) patients are Hispanic. Few data are available, however, regarding dialysis adequacy and anemia management in Hispanic patients receiving peritoneal dialysis in the U.S.

Methods

Data from the Health Care Financing Administration (HCFA) ESRD Core Indicators Project were used to assess racial and ethnic differences in selected intermediate outcomes for peritoneal dialysis patients.

Results

Of the 1219 patients for whom data were available from the 1997 sample, 9% were Hispanic, 24% were non-Hispanic blacks, and 59% were non-Hispanic whites. Hispanics were more likely to have diabetes mellitus as a cause of ESRD compared to blacks or whites, and both Hispanics and blacks were younger than white patients (both p < 0.001). Although whites had higher weekly Kt/V and creatinine clearance values compared to blacks or Hispanics ( p < 0.05), blacks had been dialyzing longer ( p < 0.01) and were more likely to be anuric compared to the other two groups ( p < 0.001). Blacks had significantly lower mean hematocrit values ( p < 0.001) and a greater proportion of patients who had a hematocrit level less than 28% ( p < 0.05) compared to Hispanics or whites, despite receiving significantly larger weekly mean epoetin alfa doses ( p < 0.05) and having significantly higher mean serum ferritin concentrations ( p < 0.01). Multivariate logistic regression analysis revealed significant differences by race/ethnicity for experiencing a weekly Kt/V urea < 2.0 and hypertension, but not for other intermediate outcomes examined (weekly creatinine clearance < 60 L/week/1.73 m2, Hct < 30%, and serum albumin < 3.5/3.2 g/dL).

Conclusion

Hispanics had adequacy values similar to blacks and anemia parameters similar to whites. Additional studies are needed to determine the etiologies of the differences in intermediate outcomes by racial and ethnic groupings in peritoneal dialysis patients.
The Role of Peritoneal Dialysis as the First-Line Renal Replacement Modality
Authors: Van Biesen W. , Vanholder R. , Lameire N.
Published: February 2020

Twenty years after its introduction, peritoneal dialysis (PD) is a well-established alternative to hemodialysis (HD) as a modality of renal replacement therapy. Much debate and research is apparent in the literature, comparing hemodialysis and PD as “opposite” modalities and trying to ascertain which modality should be more optimal.

In our opinion, HD and PD are two distinct modalities, each with its own advantages and disadvantages. In addition, it is clear that for both HD and PD, rates of technique failure are high, causing patients to transfer between modalities. The question is thus not which modality is best, but rather, which flow-chart of modalities makes best use of the advantages of each modality, while avoiding its disadvantages. In this respect, HD and PD appear to be complementary modalities.

The better preservation of residual renal function, lower risk of infection with hepatitis B and C, better outcome after transplantation, preservation of vascular access, and lower costs are arguments to promote PD as a good initial treatment. When PD-related problems arise (adequacy, ultrafiltration, peritonitis, patient burnout), a timely transfer to HD has to be planned.

This editorial tries to review arguments supporting the complementary nature of both modalities, and especially the role of PD as the first-line renal replacement therapy.
Longitudinal Study of Peritoneal Membrane Function in Continuous Ambulatory Peritoneal Dialysis: Relationship with Peritonitis and Fibrosing Factors
Authors: Wong Teresa Y.H. , Szeto Cheuk-Chun , Lai Ka-Bik , Lam Christopher W.K. , Lai Kar-Neng , Li Philip K.T.
Published: February 2020

Background

The peritoneal equilibration test (PET) is a useful assessment of peritoneal function in continuous ambulatory peritoneal dialysis (CAPD) patients. However, the natural course of longitudinal change in peritoneal transport is not well defined.

Patients

We studied 105 unselected CAPD patients. Average age at enrollment was 50.7 ± 11.3 years.

Methods

A PET was performed at enrollment. Peritoneal transport was expressed as dialysate-to-plasma creatinine ratio at 4 hours (D/P). Fibrosing factors and mesothelial cell markers, including TGFJJ, epidermal growth factor (EGF), platelet-derived growth factor (PDGF), hyaluronan, and cancer antigen 125 (CA125), were measured in overnight peritoneal dialysate effluent (PDE). Patients were followed for two years. Peritonitis episodes were recorded. Severe peritonitis was defined as an episode that required catheter removal or antibiotic therapy for more than 3 weeks. After two years, 75 patients were still alive and on CAPD.

Results

The PET was repeated in 64 patients, of whom 35 were male and 9 had diabetes. The change in D/P over two years was represented as ΔD/P. No significant change in peritoneal transport was seen after two years (D/P: 0.56 ± 0.12 vs 0.55 ± 0.13). A centripetal pattern of change in D/P was observed. The ΔD/P had normal distribution and was inversely correlated with D/P at baseline ( r = -0.427, p < 0.005). Both results suggest a regression-to-mean phenomenon. The ΔD/P had no significant correlation with the total number of peritonitis episodes (Spearman r = 0.052, p = 0.74), but after severe peritonitis, affected patients had higher ΔD/P than patients who experienced no severe infection (0.040 ± 0.136 vs -0.032 ± 0.120, p < 0.05). For patients with no episodes of severe peritonitis (n = 47), ΔD/P was weakly correlated with baseline TGFβ level ( r = -0.506, p < 0.01). No correlation was seen between the levels of other fibrosing factors and change in peritoneal transport.

Conclusions

Our findings suggest that the centripetal change of peritoneal transport probably reflects a regression-to-mean phenomenon. Peritoneal transport increases after severe peritonitis. The role of TGFβ levels in PDE with regard to longitudinal change in peritoneal transport requires further study.
Serum Albumin and Other Serum Protein Fractions in Stable Patients on Peritoneal Dialysis
Authors: Caravaca Francisco , Arrobas Manuel , Dominguez Carmen
Published: February 2020

Background

Hypoalbuminemia is common in peritoneal dialysis (PD) patients; but the reduction in serum albumin levels (SAlb) that should be expected in stable PD patients is less clear.

Objectives

To determine prospectively, in a group of stable PD patients without comorbid conditions, the changes in SAlb concentration and in the concentrations of the other serum protein fractions. To investigate the best determinants of a significant decrease in SAlb levels.

Design

Prospective observational study.

Methods

Seventeen PD patients in stable clinical condition, with no signs of systemic inflammatory response, were included in the study. SAlb and the electrophoretic pattern of serum proteins were determined immediately before PD start, and after 6, 9, 12, 15, 18, 21, and 24 months on PD. In each study period, clinical characteristics, adequacy parameters, protein catabolic rate (PNPNA: protein equivalent of non protein nitrogen appearance), and protein losses were determined. Patients were divided into two subgroups according to whether SAlb decreased less than 10%, or 10% or more, from baseline values after 24 months on PD. The main differences between the subgroups were investigated.

Results

Mean SAlb did not decrease significantly after 24 months on PD (from baseline 3.99 ± 0.46 g/dL to 3.80 ± 0.54 g/dL), though percentage SAlb values did (58.36% ± 5.58% vs 55.15% ± 5.42%, p < 0.01). A weak increase in α2-globulin was observed after 18 months on PD (from 10.62% ± 2.53% to 12.96% ± 2.51%, p = 0.001). α1-Globulin showed a sustained increase from a mean baseline value of 3.51% ± 1.09% to 6.83% ± 2.13% after 24 months ( p < 0.0001). Seven patients had a reduction in SAlb greater than 10% after 24 months on PD. Kt/V urea and residual renal function tended to be lower in patients whose SAlb decreased. Mean PNPNA was significantly lower in patients who had a reduction in SAlb (0.76 ± 0.12 g/kg/day vs 0.96 ± 0.12 g/kg/day, p < 0.0001). However, total protein loss was even greater in patients who had no SAlb reduction.

Conclusions

After 24 months on PD, a mean reduction in SAlb of 10% – 15% from baseline values should be expected only in those stable patients whose PNPNA is low.
The Role of Lean Body Mass as a Nutritional Index in Chinese Peritoneal Dialysis Patients—Comparison of Creatinine Kinetics Method and Anthropometric Method
Authors: Szeto Cheuk-Chun , Kong Johnathan , Wu Alan K.L. , Wong Teresa Y.H. , Wang Angela Y.M. , Li Philip K.T.
Published: February 2020

Objective

To compare, in Chinese continuous ambulatory peritoneal dialysis (CAPD) patients, the creatinine kinetics method (LBM-CK) and the anthropometric method (LBM-AM) for determining lean body mass (LBM).

Design

Single-center cross-sectional study.

Patients and Methods

We studied 151 unselected CAPD patients (78 males, 73 females). We calculated LBM-CK and LBM-AM using standard formulas. The results of the two methods were then compared by the Bland and Altman method. Dialysis adequacy and other nutritional indices, including total Kt/V, weekly creatinine clearance (CCr), residual glomerular filtration rate (GFR), protein nitrogen appearance (PNA), subjective global assessment (SGA), and serum albumin, were measured simultaneously.

Results

The mean age of the patients was 55.6 ± 12.2 years, and the mean duration of dialysis was 33.6 ± 28.5 months. The mean body mass index (BMI) was 22.7 ± 3.7. The average LBM-AM was 43.6 ± 8.0 kg; the average LBM-CK was 33.0 ± 9.3 kg. The difference between the calculated LBM-AM and LBM-CK was 10.7 kg, with LBM-AM always giving a higher value; the limits of agreement were –5.8 kg and 27.1 kg. The difference between the two measures correlated with residual GFR (Pearson r = 0.629, p < 0.001). After normalizing for desired body weight, LBM-AM was only modestly correlated with serum albumin level. No correlations were found between overall SGA score or normalized protein nitrogen appearance (nPNA) and LBM-AM or LBM-CK.

Conclusions

In Chinese patients at least, a substantial discrepancy exists between LBM-AM and LBM-CK. The difference is especially marked in patients with significant residual renal function. The optimal method for determining LBM remains obscure in Chinese CAPD patients. Moreover, LBM correlated poorly with other nutritional indices. Multiple parameters should be taken into consideration in an assessment of nutritional status of CAPD patients.
Management of High Peritoneal Transporters
Authors: Agrawal Alok , Nolph Karl D.
Published: February 2020

High transporters on chronic peritoneal dialysis are challenged by increased protein losses, high glucose absorption with associated metabolic abnormalities, and poor ultrafiltration. Furthermore, the relative risk of mortality and technique failure is higher in high transporters than in patients of other transport types. An approach for satisfactory management of such patients on peritoneal dialysis (PD) has not been clearly demonstrated.
Glucose Degradation Products and the Peritoneal Mesothelium
Authors: Jörres Achim , Bender Thorsten O. , Witowski Janusz
Published: February 2020

Conventional heat-sterilized, glucose-based peritoneal dialysis (PD) fluids contain significant amounts of glucose degradation products (GDPs) such as aldehydes and dicarbonyl compounds (glyoxal, methylglyoxal). These GDPs have been shown to impair cell functions in various in vitro experimental models. In peritoneal mesothelial cells, GDPs dose-dependently inhibit cell proliferation and mediator synthesis. In addition, some GDPs potently promote generation of advanced glycation end-products (AGEs). Immunohistochemistry finds AGEs in the peritoneal membrane of chronic continuous ambulatory peritoneal dialysis (CAPD) patients, suggesting that peritoneal AGE accumulation may be involved in chronic peritoneal fibrosis.

The formation of GDPs might be prevented by filter-sterilization of PD fluids. Another option is to separate the glucose and the buffer system in dual-chambered or multi-chambered containers. In these systems, the glucose is kept in a separate compartment at high concentration and very low pH—both conditions being known to minimize the degree of glucose decomposition during autoclaving. Initial experimental evidence suggests that these novel, multi-chambered fluids significantly improve in vitro biocompatibility; however, the clinical relevance of these results remains to be established in clinical trials.
Effects of Bicarbonate/Lactate Solution on Peritoneal Advanced Glycosylation End-Product Accumulation
Authors: Park Min Sun , Kim Jin Kook , Holmes Cliff , Weiss and Miriam F.
Published: February 2020

Advanced glycosylation end-products (AGEs) are associated with diabetic complications and peritoneal damage after long-term peritoneal dialysis (PD) with high glucose dialysis solutions. Glucose degradation products (GDPs) derived during heat sterilization of high glucose dialysis solutions are thought to accelerate AGE formation. A new technique of separating glucose from electrolytes has yielded markedly lower GDP levels and permitted the use of dialysis solutions containing the physiologic buffer bicarbonate. Formation of AGEs in vitro with this new solution is significantly lower compared with formation of AGEs with conventional solutions.

The purpose of the present study was to investigate the effect of long-term intraperitoneal use of new, neutral dialysis solution (B/L) containing bicarbonate (25 mmol/L) and lactate (15 mmol/L) on peritoneal AGE accumulation and permeability. Normal male Sprague–Dawley rats were used. Twice daily for 12 weeks, 30 mL of new solution (B/L) or conventional solution [Lac (lactate 40 mmol/L)] was injected into the peritoneal cavity of the test rats. As a control, rats that were not injected were kept for 12 weeks in the same manner as the test rats. After 12 weeks, a 2-hour peritoneal equilibration test (PET) was performed in the test rats. After the PET, the parietal peritoneum and liver were obtained for evaluation of peritoneal morphology and for immunohistochemistry for AGE. Intensity of AGE staining was semi-quantitatively graded from 0 to 3. The omentum was also obtained and immediately frozen for analysis of pentosidine content by high-performance liquid chromatography. Compared with findings in the control group, hematoxylin and eosin staining of the parietal peritoneum and liver samples revealed partial denudation of mesothelial cells in the Lac group; denudation was not remarkable in the B/L group. The B/L solution showed significantly less AGE staining in the peritoneal cavity compared to conventional solution. However, B/L solution failed to lower pentosidine levels. Intraperitoneal volume and the ratio of dialysate glucose at 2 hours to dialysate glucose at instillation (D2/D0 glucose) were significantly lower and the ratio of dialysate urea to plasma urea at 2 hours (D2/P2 urea) was significantly higher in the Lac and B/L groups than in the control group. Intra-peritoneal volume was significantly higher in the B/L group than in the Lac group; D2/D0 glucose and D2/P2 urea did not differ between the two groups.

In conclusion, peritoneal ultrafiltration decreased after long-term PD. The B/L solution showed a small but statistically significant protective effect against decreasing ultrafiltration as compared with Lac solution. The B/L solution attenuated peritoneal AGE accumulation compared with conventional solution, but did not affect peritoneal pentosidine levels. These findings indicate that biochemical kinetics of various AGE peptides are not unique, but multivalent.
Biocompatibility of New Peritoneal Dialysis Solutions: What Can We Hope to Achieve?
Authors: Chung Sung Hee , Stenvinkel Peter , Bergström Jonas , Lindholm Bengt
Published: February 2020

Despite the bioincompatibility of the “old”, standard, high glucose, lactate-buffered peritoneal dialysis (PD) solutions, PD is itself a highly successful dialysis modality with patient survival equivalent to that of hemodialysis (HD) during the initial 3 – 5 years of dialysis therapy. Nevertheless, PD technique survival is often limited by infectious complications and alterations in the structure and function of the peritoneal membrane. These local changes also have a negative impact on patient survival owing to systemic effects such as those often seen in patients with high peritoneal transport rate and loss of ultrafiltration (UF) capacity.

Patient mortality remains unacceptably high in both HD and PD patients, with most premature deaths being associated with signs of malnutrition, inflammation, and atherosclerotic cardiovascular disease (MIA syndrome). These systemic signs are likely to be influenced by PD solutions both directly and indirectly (via changes in the peritoneal membrane). New, biocompatible PD solutions may have favorable local effects (viability and function of the peritoneal membrane) and systemic effects (for example, on MIA syndrome). Amino acid–based solution [Nutrineal (N): Baxter Healthcare Corporation, Deerfield, IL, U.S.A.] may improve nutritional status as well as peritoneal membrane viability. Bicarbonate/lactate–buffered solution [Physioneal (P): Baxter Healthcare Corporation] may ameliorate local and systemic effects of low pH, high lactate, and high glucose degradation products. Icodextrin-based solution [Extraneal (E): Baxter Healthcare SA, Castlebar, Ireland] may improve hypertension and cardiovascular problems associated with fluid overload and may extend time on therapy in patients with loss of UF capacity.

The positive effects of each of these new, biocompatible solutions have been demonstrated in several studies. It is likely that the combined use of N, P, and E solutions will produce favorable synergies in regard to both local effects (peritoneal viability) and systemic effects (less malnutrition, inflammation, and fluid overload). Solution combination is an exciting area for clinical study in the coming years. Furthermore, dialysis fluid additives such as hyaluronan, which protects and improves the function of the peritoneal membrane, may further improve PD solutions. The new, biocompatible PD solutions represent an entirely new era in the evolution of the PD therapy; they are likely to have markedly positive effects on both PD technique and PD patient survival in coming years.
Peritoneal Dialysis Clearance can Replace Residual Renal Function
Authors: Aslam Nabeel , Bernardini Judith , Fried Linda , Piraino Beth
Published: February 2020

Objective

There is controversy whether increasing peritoneal clearance effectively substitutes for declining residual renal function. We studied the impact of renal and peritoneal clearances on outcome, controlling for comorbidity.

Design

Registry database.

Settings

Four dialysis centers.

Patients

Incident peritoneal dialysis patients.

Methods

Data were collected prospectively on 90 incident patients between 1991 and 1999. At the end of their first year on peritoneal dialysis, patients were divided into groups based on the first year's clearance results: group 1 ( n = 62) had weekly Kt/V greater than or equal to 2.0 and creatinine clearance (CCr/1.73 m2) greater than or equal to 60 L throughout the first year; group 2 ( n = 28) fell below these targets due to loss of residual renal function and then reached targets due to prescription change.

Main Outcome Measures

Patient and technique survival.

Results

Both groups were similar in baseline characteristics except age (57 years vs 49 years, p = 0.02) and initial albumin (34.4 g/L vs 37.5 g/L, p = 0.001). One-year patient survival after grouping was similar in both groups (86.3% vs 80.9%, p = 0.72). Cox proportional hazard model, controlling for comorbidity, did not show “group” to be a significant predictor of outcome ( p = 0.96). One-year technique survival after grouping was similar in both groups (77.3% vs 83.2%, log rank p = 0.89). For technique failure, Cox proportional hazard model showed peritonitis ( p = 0.004) to be the only significant predictor of worse outcome.

Conclusions

Peritoneal dialysis patients with improved clearances due to prescription changes had survival comparable to patients who never fell below target. This suggests that loss of residual renal function may be replaced by increasing peritoneal dialysis clearance. A large multicenter trial to study this important question further is needed.
Are North American Nephrologists Biased against Peritoneal Dialysis?
Authors: Charest Andre F. , Mendelssohn David C.
Published: February 2020

Objective

To examine possible bias against peritoneal dialysis (PD) by nephrologists less familiar with it.

Design

Secondary analysis of a previously reported survey.

Participants

All practicing Canadian nephrologists ( n = 290, response rate 66.2%) and a subgroup of American nephrologists who were members of the National Kidney Foundation Council on Dialysis ( n = 507, response rate 47.3%). Responses were then subdivided by type of dialysis practice: mainly or only hemodialysis (HD, n = 117), mainly or only PD ( n = 16), or both HD and PD ( n = 232).

Intervention

Self-administered mailed questionnaire.

Main Outcome Measures

Opinions and attitudes of nephrologists concerning patient characteristics favoring one dialysis modality over the other, as well as the relative utilization of HD and PD currently and in a hypothetical ideal situation.

Results

The main differences were present between physicians practicing mainly HD and physicians practicing mainly PD, with those practicing both giving answers usually intermediate to the others. The maximum weight suitable for PD was 10 kg less according to HD-oriented nephrologists compared with PD-oriented nephrologists (97.8 kg vs 108.5 kg). All nephrologists agreed that, ideally, 40% of prevalent end-stage renal disease patients should be on PD to optimize cost-effectiveness, whereas the proportion should be between 32% and 45% when one optimizes survival, wellness, and quality of life. In general, differences between groups were small.

Conclusions

Most nephrologists favored a proportion of PD higher than the current prevalence seen in either Canada or the U.S.A. If physicians’ biases are contributing to the distribution of dialysis modalities, they are not likely to be major factors. Unknown but important factors, external to the physician, may shape modality distribution more than the opinions and attitudes of physicians. If a more balanced and cost-effective dialysis delivery system is desired, more understanding and manipulation of these non physician-related factors will be required.