bluuebunny/crossref_metadata_2025 huggingface dataset:
The long noncoding RNA TINCR promotes self-renewal of human liver cancer stem cells through autophagy activation
Authors: Shi Jing , Guo Cao , Li Yang , Ma Junli
Published: November 2022

Hepatocellular carcinoma (HCC) is an extraordinarily heterogeneous tumor, which holds high recurrence and metastasis rates. Liver cancer stem cells (LCSCs) have been considered to be important influencing factors of these pathological properties, but the underlying mechanisms are poorly understood in HCC. Considerable evidences have shown that autophagy has an important role in cancer stemness. However, it is still unknown whether a long noncoding RNA (lncRNA) TINCR is involved in autophagy and self-renewal maintenance of HCC. In this study, TINCR was found to be highly expressed in HCC tissues and LCSCs. In vitro and in vivo assays for the first time showed that TINCR was required for LCSC self-renewal and tumorigenesis. Moreover, gene ontology analysis revealed the involvement of autophagy in the maintenance of TINCR-regulated stemness. Mechanically, TINCR was associated with polypyrimidine tract binding protein 1 (PTBP1) protein, which further promoted the transcription activity of autophagy related gene ATG5. In conclusion, we demonstrated that TINCR regulated LCSC self-renewal by autophagy activation through PTBP1/ATG5 regulatory pathway, offering a potential new target for HCC therapy.
Crystal growth in confinement
Authors: Kohler Felix , Pierre-Louis Olivier , Dysthe Dag Kristian
Published: November 2022

The growth of crystals confined in porous or cellular materials is ubiquitous in Nature and forms the basis of many industrial processes. Confinement affects the formation of biominerals in living organisms, of minerals in the Earth’s crust and of salt crystals damaging porous limestone monuments, and is also used to control the growth of artificial crystals. However, the mechanisms by which confinement alters crystal shapes and growth rates are still not elucidated. Based on novel in situ optical observations of (001) surfaces of NaClO3 and CaCO3 crystals at nanometric distances from a glass substrate, we demonstrate that new molecular layers can nucleate homogeneously and propagate without interruption even when in contact with other solids, raising the macroscopic crystal above them. Confined growth is governed by the peculiar dynamics of these molecular layers controlled by the two-dimensional transport of mass through the liquid film from the edges to the center of the contact, with distinctive features such as skewed dislocation spirals, kinetic localization of nucleation in the vicinity of the contact edge, and directed instabilities. Confined growth morphologies can be predicted from the values of three main dimensionless parameters.
Intensive grassland management disrupts below-ground multi-trophic resource transfer in response to drought
Authors: Chomel Mathilde , Lavallee Jocelyn M. , Alvarez-Segura Nil , Baggs Elizabeth M. , Caruso Tancredi , de Castro Francisco , Emmerson Mark C. , Magilton Matthew , Rhymes Jennifer M. , de Vries Franciska T. , Johnson David , Bardgett Richard D.
Published: November 2022

Modification of soil food webs by land management may alter the response of ecosystem processes to climate extremes, but empirical support is limited and the mechanisms involved remain unclear. Here we quantify how grassland management modifies the transfer of recent photosynthates and soil nitrogen through plants and soil food webs during a post-drought period in a controlled field experiment, using in situ 13C and 15N pulse-labelling in intensively and extensively managed fields. We show that intensive management decrease plant carbon (C) capture and its transfer through components of food webs and soil respiration compared to extensive management. We observe a legacy effect of drought on C transfer pathways mainly in intensively managed grasslands, by increasing plant C assimilation and 13C released as soil CO2 efflux but decreasing its transfer to roots, bacteria and Collembola. Our work provides insight into the interactive effects of grassland management and drought on C transfer pathways, and highlights that capture and rapid transfer of photosynthates through multi-trophic networks are key for maintaining grassland resistance to drought.
Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1
Authors: Moulana Alief , Dupic Thomas , Phillips Angela M. , Chang Jeffrey , Nieves Serafina , Roffler Anne A. , Greaney Allison J. , Starr Tyler N. , Bloom Jesse D. , Desai Michael M.
Published: November 2022

The Omicron BA.1 variant emerged in late 2021 and quickly spread across the world. Compared to the earlier SARS-CoV-2 variants, BA.1 has many mutations, some of which are known to enable antibody escape. Many of these antibody-escape mutations individually decrease the spike receptor-binding domain (RBD) affinity for ACE2, but BA.1 still binds ACE2 with high affinity. The fitness and evolution of the BA.1 lineage is therefore driven by the combined effects of numerous mutations. Here, we systematically map the epistatic interactions between the 15 mutations in the RBD of BA.1 relative to the Wuhan Hu-1 strain. Specifically, we measure the ACE2 affinity of all possible combinations of these 15 mutations (215 = 32,768 genotypes), spanning all possible evolutionary intermediates from the ancestral Wuhan Hu-1 strain to BA.1. We find that immune escape mutations in BA.1 individually reduce ACE2 affinity but are compensated by epistatic interactions with other affinity-enhancing mutations, including Q498R and N501Y. Thus, the ability of BA.1 to evade immunity while maintaining ACE2 affinity is contingent on acquiring multiple interacting mutations. Our results implicate compensatory epistasis as a key factor driving substantial evolutionary change for SARS-CoV-2 and are consistent with Omicron BA.1 arising from a chronic infection.
Increased slow dynamics defines ligandability of BTB domains
Authors: Kharchenko Vladlena , Linhares Brian M. , Borregard Megan , Czaban Iwona , Grembecka Jolanta , Jaremko Mariusz , Cierpicki Tomasz , Jaremko Łukasz
Published: November 2022

Efficient determination of protein ligandability, or the propensity to bind small-molecules, would greatly facilitate drug development for novel targets. Ligandability is currently assessed using computational methods that typically consider the static structural properties of putative binding sites or by experimental fragment screening. Here, we evaluate ligandability of conserved BTB domains from the cancer-relevant proteins LRF, KAISO, and MIZ1. Using fragment screening, we discover that MIZ1 binds multiple ligands. However, no ligands are uncovered for the structurally related KAISO or LRF. To understand the principles governing ligand-binding by BTB domains, we perform comprehensive NMR-based dynamics studies and find that only the MIZ1 BTB domain exhibits backbone µs-ms time scale motions. Interestingly, residues with elevated dynamics correspond to the binding site of fragment hits and recently defined HUWE1 interaction site. Our data argue that examining protein dynamics using NMR can contribute to identification of cryptic binding sites, and may support prediction of the ligandability of novel challenging targets.
Covalent transfer of chemical gradients onto a graphenic surface with 2D and 3D control
Authors: Xia Yuanzhi , Sevim Semih , Vale João Pedro , Seibel Johannes , Rodríguez-San-Miguel David , Kim Donghoon , Pané Salvador , Mayor Tiago Sotto , De Feyter Steven , Puigmartí-Luis Josep
Published: November 2022

Control over the functionalization of graphenic materials is key to enable their full application in electronic and optical technologies. Covalent functionalization strategies have been proposed as an approach to tailor the interfaces’ structure and properties. However, to date, none of the proposed methods allow for a covalent functionalization with control over the grafting density, layer thickness and/or morphology, which are key aspects for fine-tuning the processability and performance of graphenic materials. Here, we show that the no-slip boundary condition at the walls of a continuous flow microfluidic device offers a way to generate controlled chemical gradients onto a graphenic material with 2D and 3D control, a possibility that will allow the sophisticated functionalization of these technologically-relevant materials.
Regulating electron configuration of single Cu sites via unsaturated N,O-coordination for selective oxidation of benzene
Authors: Zhang Ting , Sun Zhe , Li Shiyan , Wang Baojun , Liu Yuefeng , Zhang Riguang , Zhao Zhongkui
Published: November 2022

Developing highly efficient catalyst for selective oxidation of benzene to phenol (SOBP) with low H2O2consumption is highly desirable for practical application, but challenge remains. Herein, we report unique single-atom Cu1-N1O2coordination-structure on N/C material (Cu-N1O2SA/CN), prepared by water molecule-mediated pre-assembly-pyrolysis method, can efficiently boost SOBP reaction at a 2:1 of low H2O2/benzene molar ratio, showing 83.7% of high benzene conversion with 98.1% of phenol selectivity. The Cu1-N1O2sites can provide a preponderant reaction pathway for SOBP reaction with less steps and lower energy barrier. As a result, it shows an unexpectedly higher turnover frequency (435 h−1) than that of Cu1-N2(190 h−1), Cu1-N3(90 h−1) and Cu nanoparticle (58 h−1) catalysts, respectively. This work provides a facile and efficient method for regulating the electron configuration of single-atom catalyst and generates a highly active and selective non-precious metal catalyst for industrial production of phenol through selective oxidation of benzene.
Improved finite element method for flow, heat and solute transport of Prandtl liquid via heated plate
Authors: Hafeez Muhammad Bilal , Krawczuk Marek , Jamshed Wasim , Kaneez Hajra , Hussain Syed M. , El Din El Sayed M. Tag
Published: November 2022

In the current study, a vertical, 3D-heated plate is used to replicate the generation of heat energy and concentration into Prandtl liquid. We discuss how Dufour and Soret theories relate to the equations for concentration and energy. In order to see how effectively particles, interact with heat and a solvent, hybrid nanoparticles are used. It does away with the phenomena of viscous dissipation and changing magnetic fields. The motivation behind the developed study is to optimize solvent and heat storage uses in the biological and industrial domains. This article's major goal is to explore the aspects of thermal energy and mass transfer that influence how nanoparticles, hybrid nanoparticles, and 3D melting surface sheets behave. Variable thermal efficiency and variable mass transfer are combined. The system of generated PDEs (difference equations) includes the concentration, velocity, and heat energy equations. The numerical calculations are done for Silver (Ag), Molybdenum Disulfide (MoS2) nanoparticles with Ethylene glycol (C2H6O2) as the base fluid using a boundary layer approach to the mathematical formulation. The system of ODEs is formulated through transformations in order to find a solution. A Galerkin finite element algorithm (G-FEA) is adopted to analyze various aspects versus different parameters. It has been found that motion into hybrid nanoparticles is reduced by motion into nanoparticles. Additionally, differences in heat energy and solvent particle sizes are associated with modifications in magnetic, Dufour, Eckert, and Soret numbers. In contrast to hybrid nanostructures, the output of thermal energy is usually observed to be substantially higher. The magnetic field parameter decreases the particle velocity. In contradiction to the Eckert number, bouncy parameter, and magnetic parameter set values, the maximum quantity of heat energy is obtained. variable thermal conductivity's function. The 3D heated vertical surface convective heat transfer of nanofluids and hybrid nanofluids under the impact of a heat source, thermal radiation, and viscous dissipation has not yet been studied, as far as the authors are aware.
Genomic and ecological evidence shed light on the recent demographic history of two related invasive insects
Authors: Poveda-Martínez Daniel , Salinas Nicolas A. , Aguirre María Belén , Sánchez-Restrepo Andrés F. , Hight Stephen , Díaz-Soltero Hilda , Logarzo Guillermo , Hasson Esteban
Published: November 2022

Hypogeococcus pungens is a species complex native to southern South America that is composed of at least five putative species, each one specialized in the use of different host plants. Two of these undescribed species were registered as invasive in Central and North America: Hyp-C is a cactophagous mealybug that became an important pest that threatens endemic cactus species in Puerto Rico, and Hyp-AP feeds on Amaranthaceae and Portulacaceae hosts, but does not produce severe damage to the host plants. We quantified genomic variation and investigated the demographic history of both invasive species by means of coalescent-based simulations using high throughput sequencing data. We also evaluated the incidence of host plant infestation produced by both species and used an ecological niche modeling approach to assess potential distribution under current and future climatic scenarios. Our genetic survey evinced the footprints of strong effective population size reduction and signals of genetic differentiation among populations within each species. Incidence of plant attacks varied between species and among populations within species, with some host plant species preferred over others. Ecological niche modeling suggested that under future climatic scenarios both species would expand their distribution ranges in Puerto Rico. These results provide valuable information for the design of efficient management and control strategies of the Puerto Rican cactus pest and shed light on the evolutionary pathways of biological invasions.
Analysis on ecological characteristics of Mississippian coral reefs in Langping, Guangxi
Authors: Yang Dayong , Chang Honglun , Liu Xiao , Wan Peng , Shen Liming
Published: November 2022

Several Late Viséan-Serpukhovian coral reefs were identified in Langping, Tianlin. They provided an opportunity to investigate paleo-environments suitable for the development of reef-building communities and the construction of coral reefs in Langping. In this paper, part of the reef-building environmental and the ecological characteristics of coral reefs then were elaborated by analyzing the development settings, palaeogeography, sedimentation of reefs, the response to hydrodynamic conditions of reef-building corals, effects of disturbance and non-reef-building organism on reef communities, and the influence of coral morphology on reef development. It is considered that the sedimentary environment of Langping in Late Viséan-Serpukhovian is suitable for the development of benthic communities. The current appearance of reefs is determined by both coral populations ecological characteristics and reef-building environment.
Influences of sleep and lifestyle factors on the risk for covid-19 infections, from internet survey of 10,000 Japanese business workers
Authors: Nakashima Masahiro , Amano Ryota , Nishino Naoya , Osada Yasutaka , Watanabe Yuriko , Miyake Akifumi , Chiba Shintaro , Nishino Seiji
Published: November 2022

We conducted an internet survey to assess sociodemographic variables, lifestyle factors, sleep problems, and comorbidities for sleep apnea syndrome (SAS) in COVID-19 and influenza (FLU) infections. Data from 10,323 workers (50.0% male) were analyzed. COVID-19 was diagnosed in 144 subjects (COVID-19+), and 8,693 were classified as not suspected to be infected (COVID-19−). SAS had been diagnosed in 35.4% of the COVID-19+ subjects, but only 231 (2.7%) of the 8,693 COVID-19− subjects. COVID-19+ subjects were more susceptible to FLU (35.4%) compared to COVID-19− subjects (3.0%). A multivariate analysis revealed that higher risks of COVID-19+ were linked to the following factors: going out without a face mask (OR 7.05, 95% CI 4.53–11.00), FLU+ (OR 6.33, 95% CI 3.80–10.54), excessive exercise before going to sleep (OR 2.10, 95% CI 1.63–2.70), SAS+ (OR 5.08, 95% CI 2.88–8.94), younger age (OR 1.05, 95% CI 1.03–1.07), falling sleep while sitting or talking with someone (OR 3.70, 95% CI 2.30–5.95), and use of hypnotics (OR 2.28, 95% CI 1.20–4.30). Since sleep impairment played a relatively small role in COVID-19+/SAS− subjects, we assume that SAS itself was a more significant risk factor for COVID-19 infection rather than sleep impairment. A better understanding of the mechanisms that result in increased susceptibility to COVID-19 in SAS is vital for helping prevent COVID-19.
Effect of marigold (Tagetes erecta L.) on soil microbial communities in continuously cropped tobacco fields
Authors: Huang Feiyan , Deng Xiaopeng , Gao Lingling , Cai Xianjie , Yan Ding , Cai Yongzhan , Chen Xiaolong , Yang Min , Tong Wenjie , Yu Lei
Published: November 2022

Root-knot nematode disease is a catastrophic soil-borne disease in tobacco production. The regulation of natural microbial communities is considered a good disease management approach to suppress the incidence of soilborne diseases. In this study, the effects of tobacco (Nicotiana tabacum L.)-marigold (Tagetes erecta L.) rotation on the diversity and structure of soil microbial communities in continuously cropped tobacco fields were analyzed to manage this devastating pathogen. The results showed that the soil bacterial OTUs increased after marigold rotation and that the bacterial Shannon, ACE, Chao1 index, and fungal Shannon index were higher in the tobacco-marigold rotation fields than in the continuously cropped tobacco fields by 3.98%, 10.37%, 5.46%, and 3.43%, respectively. After marigold rotation, the relative abundances of Actinobacteria, Acidobacteria, and Ascomycota increased by 28.62%, 107.50%, and 57.44%, respectively, and the proportion of beneficial bacterial genera such as Nocardioides, Gemmatimonas, and Bradyrhizobium increased. In addition, our results also showed that rotation of marigold could effectively reduce the incidence of root-knot nematodes in the next crop of tobacco. These results indicate that marigold rotation had a positive effect on the soil microecological environment of continuously cropped tobacco fields, reducing the obstacles to continuous cropping of tobacco.
Modulating the poly-l-lysine structure through the control of the protonation–deprotonation state of l-lysine
Authors: Stagi Luigi , Sini Martina , Carboni Davide , Anedda Roberto , Siligardi Giuliano , Gianga Tiberiu-Marius , Hussain Rohanah , Innocenzi Plinio
Published: November 2022

Designing the architecture of l-lysine-based polymeric structures is a highly challenging task that requires careful control of the amino acid reactive groups. Conventional processes to obtain branched polylysine need several steps and the addition of specific catalysts. In the present work, to gain a better understanding and control of the formation of l-lysine-based polymers, we have investigated the correlation between the protonation state of l-lysine and the corresponding hydrothermally grown structures. The samples have been characterized by combining optical spectroscopies, such as UV–Vis, fluorescence, and synchrotron radiation circular dichroism with structural analysis by Nuclear Magnetic Resonance, Fourier Transform Infrared spectroscopy, and dynamic light scattering. We have observed that aqueous precursor solutions with alkaline pHs promote the formation of branched structures. In contrast, high pHs favour the reactivity of the ε-amino groups leading to linear structures, as shown by circular dichroism analyses. On the other hand, acidic conditions trigger the branching of the amino acid. Interestingly, the polymeric forms of l-lysine emit in the blue because the increasing number of intermolecular hydrogen bonds promote the intermolecular charge transfer responsible for the emission. Understanding the correlation between the l-lysine charged states and the polymeric structures that could form controlling the protonation–deprotonation states of the amino acid opens the route to a refined design of polypeptide systems based on l-lysine.
Annual exposure to PM10 is related to cerebral small vessel disease in general adult population
Authors: Jeong Han-Yeong , Kim Hyun-Jin , Nam Ki-Woong , Jeong Su-Min , Kwon Hyuktae , Park Jin-Ho , Kwon Hyung-Min
Published: November 2022

Ambient air pollution is one of the most important global health issues. Although several studies have been reported the associations between air pollution and brain function or structure, impact of the air pollution on cerebral small vessel disease (cSVD) have rarely been explored in Asian adult population. We evaluated the association between exposure to air pollutants and cSVD in Korean asymptomatic adults. This cross-sectional study included 3257 participants of a health screening program from January 2006 to December 2013. All participants performed brain magnetic resonance imaging. To assess the cSVD, we considered three features such as white matter hyperintensities (WMH), silent lacunar infarction (SLI), and cerebral microbleeds (CMBs). The annual average exposure to air pollutants [particulate matter ≤ 10 μm in aerodynamic diameter (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO)] was generated. The mean [standard deviation (SD)] age of the total 3257 participants was 56.5 (9.5) years, and 54.0% of them were male. Among all the included participants, 273 (8.4%) had SLI and 135 (4.1%) had CMBs. The mean volume (± SD) of WMH was 2.72 ± 6.57 mL. In result of linear regression analysis, the volume of WMH was associated with various potential factors including age, height, weight, smoking and alcohol consumption status, blood pressure (BP), hypertension, and diabetes mellitus. SLI-positive group, compared to the SLI-negative group, was older, shorter, and had higher BP as well as higher frequency of hypertension and diabetes mellitus. After adjusting for covariates, the annual average concentration of PM10 was significantly associated with the volume of WMH [β (95% CI) for Model 1 = 0.082 (0.038- 0.125), p < 0.001; β (95% CI) for Model 2 = 0.060 (0.013, 0.107), p = 0.013]. CMBs were not associated with the annual average concentration of PM10. No significant associations of NO2, SO2, and CO with cSVD were observed. In conclusion, PM10 exposure is associated with significant increases in brain WMH’ volume and silent lacunar infarcts in asymptomatic adults.
Understanding Mendelian errors in SNP arrays data using a Gochu Asturcelta pig pedigree: genomic alterations, family size and calling errors
Authors: Arias Katherine D. , Álvarez Isabel , Gutiérrez Juan Pablo , Fernandez Iván , Menéndez Juan , Menéndez-Arias Nuria A. , Goyache Félix
Published: November 2022

Up to 478 Gochu Asturcelta pig parents-offspring trios (61 different families) were genotyped using the Axiom_PigHDv1 Array to identify the causes of Mendelian errors (ME). Up to 545,364 SNPs were retained. Up to 40,540 SNPs gathering 292,297 allelic mismatches were identified and were overlapped with SINEs and LINEs (Sscrofa genome 11.1). Copy number variations (CNV) were called using PennCNV. ME were classified into eight different classes according to the trio member (“Trio” meaning no assignment) and the allele on which ME was identified: TrioA/B, FatherA/B, MotherA/B, OffspringA/B. Most ME occurred due to systematic causes: (a) those assigned to the Father, Mother or Offspring occurred by null or partial null alleles characterized by heterozygote deficiency, varied with family size, involved a low number of loci (6506), and gathered most mismatches (228,145); (b) TrioB errors varied with family size, covaried with SINEs, LINEs and CNV, and involved most ME loci (33,483) and mismatches (65,682); and (c) TrioA errors were non-systematic ME with no sampling bias involving 1.2% of mismatches only and a low number of loci (1939). The influence of TrioB errors on the overall genotyping quality may be low and, since CNV vary among populations, their removal should be considered in each particular dataset. ME assignable to the Father, Mother or Offspring may be consistent within technological platforms and may bias severely linkage or association studies. Most ME caused by null or partial null alleles can be removed using heterozygote deficiency without affecting the size of the datasets.
Most Modern Approach to the Phytochemistry and Therapeutic Potential of Boswellia in Ayurvedic Formulations
Authors: Varma A. C. Karthik , Kuttappan Sasikumar , Amalraj Augustine
Published: November 2022

Ayurveda and most traditional systems of medicine have proved their efficacy in various clinical aspects and in treating various types of disorders. Shallaki, also referred to as Boswellia or Olibanum, is used in many Ayurvedic systems of medicine, mainly to treat various sorts of inflammatory disorders, especially in sandhi vata/arthritis. The Ayurvedic formulations concentrate on the use of polyherbal formulations in treating many disorders. The traditional knowledge of the ingredients has kept the pathway opened for most modern researchers and nutraceutical manufacturers to explore the phytochemical ingredients, which are responsible for the biological activities. Boswellic acids, especially keto boswellic acids, are responsible for the pharmacological activities of the gum resin extract. This chapter presents an overview of the various pharmacological activities of the Boswellia gum resin extract and the proposed mechanism of action of their phytochemical compounds with Ayurvedic-based information.
Galangal – a Promising Herb in Ayurvedic Formulations: Phytochemistry and Pharmacological Evaluations
Authors: Nille Guruprasad C. , Mishra Shardendu Kumar , Nille Omkar S. , Singh Angad Kumar , Chaudhary Anand Kumar
Published: November 2022

Galangals, the commonly used designation for three different species, namely Alpinia galanga (L.) Willd. (greater galangal), Alpinia officinarum Hance, and Alpinia calcarata Roscoe (lesser galangals), are widely used medicinal plants with a prevalent traditional name, Rasna, in Ayurveda. They are substitutes for each other in the name of Rasna in many Ayurvedic formulations. In the Ayurveda system of medicine, Rasna has effectively been used to manage various inflammatory disorders, neurodegenerative diseases, diarrhoea, stomachache, diabetes, dementia, fever, bronchial catarrh, etc. The principal phytochemicals in galangals are alkaloids, terpenoids, flavonoids, coumarins, saponins, tannins, essential oils, apigenin, chrysin, galangin-3-methyl ether, galangin, zingerone, diterpene, diterpene B, 1,8-cineol, α-pinene, galangoisoflavonoid, 1′-acetoxyeugenol acetate, protocatechuic acid, etc. Galangals are cited for their antimicrobial, antidiabetic, anti-inflammatory, antipyretic, anticancer, antispasmodic, antiviral, antifungal, cytoprotective, hepatoprotective, neuroprotective, aphrodisiac, antiemetic, antihelminthic, antiulcerative, antidiuretic, antidementia, and antiallergic properties. This chapter aims to provide comprehensive data about galangals by addressing details of the species and their present utility in various Ayurvedic formulations. It also includes their ethnomedicinal, phytochemical, and pharmacological aspects.
Correction: A self-healing, recyclable and conductive gelatin/nanofibrillated cellulose/Fe3+ hydrogel based on multi-dynamic interactions for a multifunctional strain sensor
Authors: Fu Haocheng , Wang Bin , Li Jinpeng , Xu Jun , Li Jun , Zeng Jinsong , Gao Wenhua , Chen Kefu
Published: November 2022

Correction for ‘A self-healing, recyclable and conductive gelatin/nanofibrillated cellulose/Fe3+ hydrogel based on multi-dynamic interactions for a multifunctional strain sensor’ by Haocheng Fu et al., Mater. Horiz., 2022, 9, 1412–1421, https://doi.org/10.1039/D2MH00028H.
Anti-KIT DNA aptamer-conjugated porous silicon nanoparticles for the targeted detection of gastrointestinal stromal tumors
Authors: Vijayakumar Sanahan , Nasr Seyedmehdi H. , Davis Jacob E. , Wang Edward , Zuidema Jonathan M. , Lu Yi-Sheng , Lo Yu-Hwa , Sicklick Jason K. , Sailor Michael J. , Ray Partha
Published: November 2022

A preclinical mouse model for in vivo imaging of Gastrointestinal Stromal Tumors (GIST) using KIT-aptamer targeted fluorescently-labeled porous silicon nanoparticles.
Identifying the morphology of Pt nanoparticles for the optimal catalytic activity towards CO oxidation
Authors: Duan Xinyi , Li Xiao-Yan , Zhu Beien , Gao Yi
Published: November 2022

The dynamic morphology of nanoparticles (NPs) is crucial for determining their catalytic performance.
Molecular self-assembled monolayers anomalously enhance thermal conductance across polymer–semiconductor interfaces
Authors: He Jinlong , Tao Lei , Xian Weikang , Arbaugh Tom , Li Ying
Published: November 2022

Thermal issues have become increasingly important for the performance and lifetime of highly miniaturized and integrated devices.
Nanomolar LL-37 induces permeability of a biomimetic mitochondrial membrane
Authors: Jiang Xin , Yang Chenguang , Qiu Jie , Ma Dongfei , Xu Cheng , Hu Shuxin , Han Weijing , Yuan Bing , Lu Ying
Published: November 2022

Single-molecule observations show that nanomolar LL-37 can directly permeate the lipid membrane in a lipid-specific and protein-independent manner.
High throughput processing of dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene (DNTT) organic semiconductors
Authors: Fijahi Lamiaa , Li Jinghai , Tamayo Adrián , Volpi Martina , Schweicher Guillaume , Geerts Yves H. , Mas-Torrent Marta
Published: November 2022

Alkylated linear and S-shaped DNTT derivatives are deposited at high speed. The higher solubility of S-DNTT facilitates solution processing, reaching a mobility of two orders of magnitude higher than the one found for linear DNTTs.
Oxidation-induced phase transformations of hybrid tin bromide single crystals enable the occurrence of second-harmonic generation
Authors: Yu Binyin , Yang Can , Song Zhexin , Liu Guokui , Wei Jing , Wu Qi , Dang Yangyang
Published: November 2022

Oxidation-induced phase transformations of tin-bromide hybrid single crystals enable the occurrence of second harmonic generation.
Supramolecular squares of Sn(iv)porphyrins with Re(i)-corners for the fabrication of self-assembled nanostructures performing photocatalytic degradation of Eriochrome Black T dye
Authors: Shee Nirmal Kumar , Kim Hee-Joon
Published: November 2022

Supramolecular squares composed of Sn(iv) porphyrins and Re(i) complexes formed specific nanostructured photocatalysts for the visible-light photodegradation of Eriochrome Black T dye.
Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor
Authors: Bejan Daniel S. , Sundalam Sunil , Jin Haihong , Morgan Rory K. , Kirby Ilsa T. , Siordia Ivan R. , Tivon Barr , London Nir , Cohen Michael S.
Published: November 2022

We introduce the first cysteine-targeted covalent PARP inhibitor (DB008), equipped with a clickable alkyne for enhanced PARP family-wide selectivity, and discovered that inhibition of PARP16 prevents auto-aggregation under nutrient stress.
The O-GlcNAc cycling in neurodevelopment and associated diseases
Authors: Wenzel Dawn M. , Olivier-Van Stichelen Stephanie
Published: November 2022

Proper neuronal development is essential to growth and adult brain function. Alterations at any step of this highly organized sequence of events, due to genetic mutations or environmental factors, triggers brain malformations, which are leading causes of diseases including epilepsy, intellectual disabilities, and many others. The role of glycosylation in neuronal development has been emphasized for many years, notably in studying human congenital disorders of glycosylation (CDGs). These diseases highlight that genetic defects in glycosylation pathways are almost always associated with severe neurological abnormalities, suggesting that glycosylation plays an essential role in early brain development. Congenital disorders of O-GlcNAcylation are no exception, and all mutations of the O-GlcNAc transferase (OGT) are associated with X-linked intellectual disabilities (XLID). In addition, mouse models and in vitro mechanistic studies have reinforced the essential role of O-GlcNAcylation in neuronal development and signaling. In this review, we give an overview of the role of O-GlcNAcylation in this critical physiological process and emphasize the consequences of its dysregulation.
Sparse identification for model predictive control to support long‐term voltage stability
Authors: Tran Minh‐Quan , Tran Trung Thai , Nguyen Phuong H. , Pemen Guus
Published: November 2022

Along with the increased installation of distributed energy resources (DER), long‐term voltage stability can be improved if proper coordination is developed between DERs and grid controllers, for example, Load Tap Changer (LTC). In most of the proposed methods, the steady‐state voltage‐sensitivity analysis has been implemented to predict the voltage state, which is the state's dynamic evolution in abnormal operations of the grid with high shares of DERs. This paper presents a system identification‐based model predictive control (MPC), which can coordinate DERs and LTC to restore the voltage to the pre‐fault condition after emergencies. First, the online voltage evolution is predicted based on the sparse identification of the nonlinear dynamics (SINDY) technique. Then, the SINDY‐based voltage prediction is combined with an adaptive MPC in the centralized controller. In addition, the nonlinear of DERs have been modeled to avoid the MPC‐based coordination jeopardizing the local constraints of DERs. The proposed method has been tested in a modified CIGRE benchmark network. Simulation results show that the dynamic voltage is effectively estimated by the SINDY method. Furthermore, the developed MPC model smoothly supports faster voltage recovering time with the least number of control actions of LTCs.
HKGAIL: Policy shaping via integrating human knowledge with generative adversarial imitation learning
Authors: Peng Yanfei , Tan Guozhen , Si Huaiwei
Published: November 2022

Generative adversarial imitation learning (GAIL) has shown good results in several research areas by taking advantage of generative adversarial networks. However, GAIL lacks a reward mechanism and usually adopts a model‐free approach based on stochastic policies, which is not ideal for solving complex, dynamically uncertain population intelligence problems, especially in the face of autonomous driving environments. In this paper, a policy framework is shaped by combining the human knowledge with GAIL (HKGAIL). HKGAIL embeds human decision models into the learning process to infer the underlying structure of expert demonstrations. The skills learned from expert demonstrations can directly guide the actions (policies) of the learning process of the agents, and the policies can be optimized through the feedback function of the discriminator. Experiments on both driving and landing tasks show that HKGAIL was able to better fit the policy close to the expert, and was 16.2% safer than GAIL for the driving task.
Electrophoretic deposited gold nanoparticle thin film on silver substrate
Authors: Hosseingholilou Samira , Dorranian Davoud
Published: November 2022

Effects of the deposition time and voltage on the characteristics of gold nanoparticles (NPs) thin films, prepared by the electrophoretic deposition (EPD) method on the silver substrate, were investigated experimentally. Au NPs were synthesised using the pulsed laser ablation method in distilled water. The suspended solution of the gold NPs was used as the electrolyte of EPD. An irradiation was carried out by the fundamental wavelength of a Q‐switched NdYAG laser at 1064 nm and 7 ns pulse width. The electrophoretic deposition apparatus consisted of two 2 × 2 cm pieces of silver plates as the electrodes. They were immersed in parallel with a 7 mm gap in the gold NP suspension. Five samples of gold NP thin films were prepared at different deposition times and applied voltages. Results show that the roughness, thickness and surface quality of EPD prepared thin films can be strongly controlled by the deposition time and applied voltage. The thickness of deposited films was dependent on the voltage of deposition in which their roughness was increased with increasing the deposition time. Furthermore, the reflection of deposited films was affected by the surface roughness.
The generalized semidiscrete cmKdV system and the periodic reduction
Authors: Babalic Corina N.
Published: November 2022

The complete integrability of a multicomponent differentialdifference complex mKdV system with branched dispersion relation is proven. We use two approaches for this purpose. The first one is the Hirota bilinear formalism that helps us construct the multi-soliton solutions for a system of any M coupled equations. The same soliton solutions can be obtained through the periodic reduction approach, which has as a starting point a two-dimensional semidiscrete cmKdV equation. Plots of multi-solitons are also presented.
Comparison of commercial and original methods for denoising electrical waveforms with constant or linearly variable magnitudes
Authors: Nicolae Ileana-Diana V.D. , Kostic Dusan , Nicolae Petre-Marian T. , Popescu Paul P.
Published: November 2022

Acquired electrical waveforms can be affected by white noise. The 1-st part of the paper analysis deals with the denoising of multi-period steady signals by using 3 methods: mean signal method, an original method relying on wavelet packet trees and the method implemented by the wavelet-based Matlab function wden. The signal length influence over the mean signal method’s accuracy is studied. The results yielded by the other 2 methods are also analyzed considering signals with 7 periods. Afterward the wavelet-based methods are used to denoise segments of 7 periods with linearly variable magnitudes (ascending or descending) for 3 different slopes. Artificial test signals, with rich harmonic content, were used. They were polluted by sets of 10 white noises with different powers. Maximum absolute deviations and mean square root deviations were computed considering the original signals, before pollution, versus the corresponding denoised signal. The metrics were computed relative to the maximum absolute value of the noise and allowed to determine the most accurate method.
Optimized use of Wavelet Packet Trees for the analysis of electrical waveforms
Authors: Nicolae Ileana-Diana V.D. , Nicolae Petre-Marian T. , Cîrstea Daniel C. , Gheorghe Ilie A.
Published: November 2022

Wavelet packet trees represent a topic which grows in popularity when it comes to analysis of electrical waveforms. It allows for time-frequency analysis providing information on narrower ranges of frequency (as compared to the faster Discrete Wavelet Decomposition), but the computational resources are significantly greater than that involved in other types of wavelet-based analysis. In order to allow for this type of analysis to be usable in real-time applications, that is – to reduce the runtime, original algorithms were conceived and tested. In the first part of this work, previously implemented algorithms are briefly described, along with their pros and cons. Afterward, a new runtime optimization algorithm is proposed. Details on data structures, workflow, tests and study of errors are provided. This algorithm diminishes with up to 59% the runtime required by the application of the superposition theorem in order to evaluate the contribution of clustered harmonics using WPT.
On the Ψ−uniform asymptotic stability of nonlinear Lyapunov matrix differential equations
Authors: Diamandescu Aurel
Published: November 2022

This paper deals with obtaining (necessary and) sufficient conditions for Ψ− uniform asymptotic stability of solutions of nonlinear Lyapunov matrix differential equations.
Defining the speed independence of the Boolean asynchronous systems
Authors: Vlad Serban E.
Published: November 2022

A discrete time Boolean asynchronous system consists in a function Φ : {0, 1}n→ {0, 1}nwhich iterates its coordinates Φ1, ..., Φnindependently of each other. The durations of computation of Φ1, ..., Φnare supposed to be unknown. The analysis of such systems has as main challenge characterizing their dynamics in conditions of uncertainty. For this, a very cited classical paper is [1], where the fundamental concept of speed independence is introduced. The point is, like in most of these cases, that the engineers receive from such a work intuition, combined with a certain lack of rigor. Our aim is to try a mathematical reinforcement of the Muller’s theory of the asynchronous circuits, which should be a modest homage, over time, to its authors.

A list of models used in asynchronous systems theory is given in [3]. The mathematical tools used in this analysis may be found in [2].
Ethische Abwägungen und Rückfragen zu
Xenotransplantationen
Authors: Kreß Hartmut
Published: November 2022

Xenotransplantationen sind im Licht einschlägiger medizinethischer und
-rechtlicher Kriterien sowie unter dem Vorzeichen der
Handlungsfolgenverantwortung zu erörtern. Problematisch ist, dass sie
mit Leitideen des Tierschutzes kollidieren. Andererseits ist das Anrecht von
Patient:innen auf eine dem wissenschaftlichen Stand gemäße
gesundheitliche Versorgung zu betonen. Falls die biologischen Risiken von
Xenotransplantationen beherrschbar werden sollten, könnten sie zu einem
Verfahren werden, das den Organmangel überbrückungsweise
lindert. Langfristig werden voraussichtlich andere Handlungsansätze den
Vorzug verdienen.
Lactate Clearance as an Early Prognostic Marker of Mortality for
Pediatric Trauma
Authors: Çeleğen Mehmet , Çeleğen Kübra
Published: November 2022

Background While lactate clearance (LC) has already been shown as a
prognostic indicator in clinical studies, its certain character needs to be
defined in pediatric trauma. This research aimed to evaluate the correlation
between early lactate clearance and mortality in pediatric trauma.Patients and
methods A retrospective cohort study was conducted in a university
hospital. Repeated LC was measured at admission, at the 2nd, 6th, and 12th hours
post-admission. The association of lactate clearance with mortality was analyzed
and using receiver operating characteristic (ROC) to determine the threshold
levels of lactate clearance and also logistic regression analysis was performed
to determine whether LC was an independent risk
factor.Results Seventy-eight patients were included and overall
mortality was 13%. LC values of the non-survivors was significantly
lower than survivors for LC0–2 h (28.60±14.26 vs
4.64±15.90), LC0–6 h (46.63±15.23 vs
3.33±18.07), LC0–12 h (56.97±15.53 vs
4.82±22.59) (p:<0.001, p:<0.001 and p:<0.001,
respectively). Areas under the curve of lactate clearance at the 2nd, 6th, and
12th hours after therapy start were a significant predictor for mortality
(p:<0.001, p:<0.001, and p:<0.001, respectively).
Threshold values of LC were 12.9, 19.5 and 29.3%,
respectively.Conclusion Lactate clearance was a beneficial tool to
estimate outcomes of pediatric trauma. Poor lactate clearance was a significant
marker for poor prognosis.
Chronischer beruflicher Stress: Behandlungsansätze mit
Psychotherapie
Authors: Koch Stefan , Lehr Dirk , Hillert Andreas
Published: November 2022

Psychische Erkrankungen sind zunehmend Grund für
Arbeitsunfähigkeit und Frühberentung aus
Krankheitsgründen. Sie bilden einen Hauptrisikofaktor für
eingeschränkte Teilhabe am Erwerbsleben (z. B. [1, 2]). Dennoch
wird das Thema Beruf in der psychotherapeutischen Akutversorgung oft nur
nachrangig behandelt. Wie aber kann das Thema Arbeit spezifisch in der
Psychotherapie behandelt werden? Der vorliegende Beitrag gibt einen
Überblick.
Ein Standard für Gemeindepsychiatrische Zentren in
Niedersachsen – Checkliste und Modelltreueskala
Authors: Wienberg Günther , Ostermann Jochen , Piel Ansgar , Bramesfeld Anke , Myszor Franziska , Steinhart Ingmar
Published: November 2022

Ziel der Studie Definition eines Standards für Strukturen und
Prozesse von Gemeindepsychiatrischen Zentren (GPZ), die eine ambulante und
mobile multiprofessionelle Komplex- und Intensivversorgung für Menschen
mit schweren psychischen Erkrankungen sicherstellen sollen.

Methodik Der Standard wurde unter fortlaufender Beteiligung aller
relevanten Stakeholder, darunter Akteurinnen/Akteure von drei
niedersächsischen GPZ-Modellprojekten sowie Expertinnen/Experten
aus Erfahrung, entwickelt und konsentiert.

Ergebnisse Der Standard umfasst eine Checkliste mit 12 binären und
obligatorischen GPZ-Merkmalen sowie eine Modelltreue-Skala mit 45 skalierten
Items in 9 Dimensionen.

Schlussfolgerungen Mit dem GPZ-Standard liegt erstmals ein an der
S3-Leitlinie „Psychosoziale Therapien“ orientierter
quantifizier- und überprüfbarer Merkmalskatalog für GPZ
vor.
Immunsuppression nach Organtransplantation:
Essentials
Authors: Franke Frederike , Renders Lutz , Linecker Michael , Braun Felix
Published: November 2022

Dieser Artikel soll einen Überblick über den Einsatz und
mögliche Probleme der immunsuppressiven Therapie nach solider
Organtransplantation (SOT) geben. Für einige Immunsuppressiva sind
andere Empfehlungen bezüglich der angestrebten Talblutspiegel angegeben,
als dies in der Fachinformation empfohlen ist. Wir möchten
ausdrücklich darauf hinweisen, dass es sich hierbei um die
persönliche Meinung der Autor*innen handelt.
Bevacizumab in combination with octreotide rescues a patient with liver cirrhosis, GAVE syndrome and refractory hemorrhage – a case report
Authors: Gairing Simon Johannes , Schleicher Eva Maria , Müller Lukas , Labenz Christian , Darstein Felix , Grimm Daniel , Sivanathan Visvakanth , Weinmann Arndt , Wörns Marcus-Alexander , Kloeckner Roman , Pitton Michael B. , Thieringer Florian , Rahman Khan Fareed , Galle Peter Robert , Schattenberg Jörn M. , Foerster Friedrich
Published: November 2022

Gastric antral vascular ectasia (GAVE) syndrome is a rare but often challenging etiology
of upper gastrointestinal bleeding (UGIB).

We report on a 60-year-old patient with liver cirrhosis, GAVE syndrome and recurrent and
refractory GAVE-related UGIB. During a 5-month hospital stay, the patient required a total of
82 packed red blood cells (pRBCs) and 23 gastroscopies. All endoscopic approaches, including
multiple argon plasma coagulation and band ligation sessions, remained unsuccessful.
Antrectomy was waived because of the high perioperative mortality risk in Child-Pugh B liver
cirrhosis. TIPS insertion also failed to control the bleeding. Only continuous intravenous
octreotide infusion slowed the bleeding, but this forced the patient to be hospitalized. After
144 inpatient days, administration of subcutaneous octreotide allowed the patient to be
discharged. However, the patient continued to require two pRBCs every 2–3 weeks. Based on
recently published data, we treated the patient with bevacizumab (anti-VEGF antibody)
off-label at a dose of 7.5 mg/kg body weight every three weeks in nine single doses over six
months. Since the first administration, the patient has remained transfusion-free, has not
required hospitalization, and leads an active life, working full-time. He remains on
octreotide, which has been reduced but not yet discontinued. Additionally, no adverse events
were observed.

Thus, in patients with liver cirrhosis and refractory GAVE-related hemorrhage, bevacizumab
combined with subcutaneous octreotide should be considered as an effective and durable
pharmacological treatment option.