bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Mechanisms of Notopterygii Rhizoma Et Radix for the Treatment of Arrhythmia Based on Network Pharmacology
Authors: Wei PL , Qi Yifei , Tan Yupei , Long Dehuai , Xing Wenlong , Li Xiang , Shang Juju , Liu Hongxu
Published: November 2021

Background Many experiments showed that Notopterygii Rhizoma Et Radix (NRR) can resist arrhythmia, but the mechanism of its action has not clear. Here, we investigated the possible mechanisms of NRR by network pharmacology and molecular docking and verified them experimentally. Methods Active componds and targets of NRR were retrieved by the Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database andAnalysis Platform, SymMap, and the Encyclopedia of Traditional Chinese Medicine (ETCM) databases. Arrhythmia-related targets were acquired from Comparative Toxicogenomics Database (CTD) and GeneCards databases. Overlapping targets of NRR associated with arrhythmia were acquired via Venn diagram. DAVID was applied for GO and KEGG pathway analyses. Cytoscape software and its plug-in were used for PPI network construction, module division and hub nodes screening. AutoDock Vina and qRT-PCR were carried out for validation. Results The 21 active compounds and 57 targets were obtained. Of these, coumarin was the predominant category including 15 components and 31 targets. The 5 key targets of NRR in treating arrhythmia, and these targets are involved in the apoptotic process, extrinsic apoptotic signaling pathway in absence of ligand, endopeptidase activity involved in apoptotic process by cytochrome c. The main pathways are p53 signaling pathway, Hepatitis B and Apoptosis. The results of molecular docking and qRT-PCR display good effect on hub node regulation in NRR treatment. Conclusion NRR plays an important role in anti-apoptotic mediated by modulating p53 signaling pathway, which may provide insight into future research and clinical applications in arrhythmia therapy.
Evaluation of Plasma Assisted Noninvasive Surgery (PANIS) as a New Approach for the Treatment of Conjunctival Concretions; A Clinical Case Series
Authors: Nejat Farhad , Jadidi Khosrow , eghtedari shima , Nabavi Nazanin Sadat , Malekifar Pooneh
Published: November 2021

Purpose: Plasma is one of the newest therapies recently used in Conjunctivochalasis, Conjunctival Cyst, and Blepharoplasty. This study aimed to evaluate a quick treatment modality of conjunctival concretions using plasma as a noninvasive procedure.Design: Six eyes of six patients with conjunctival concretions were evaluated in a clinical case series.Methods: The procedure was performed using plasma spots generated by the white handpiece of the Plexr device. The eyelid was everted and concretions sublimated by plasma spots from the upper and lower eyelids. Refractive Errors, visual acuity (BCVA and UCVA), Ocular Surface Disease Index (OSDI), and Intraocular pressure (IOP) were measured before and after six months of the procedure.Results: The results of 6 months follow-up show that this effective method had no recurrence or side effects. Treatment was effective in all of the patients. No complication and recurrence was observed. The OSDI score was improved to the normal range. This method had no effects on Refractive Errors, Visual Acuity, and IOP. Conclusions: Based on the results, it seems that the PANIS method can be used as a practical, quick, and straightforward approach for the treatment of conjunctival concretions.
Identifying Symptom Clusters Among Pregnant Women During Early and Late Pregnancy
Authors: Zhang Yunxue , Xu Xiaofang , Xie Zihui , Li Yuanyuan , Zhao Di , Lv Gaorong , Li Ping
Published: November 2021

Objectives
Symptom assessment and management among women in early and late pregnancy remains concerned, in consideration of multiple co-occurring symptoms; however, evaluation of multidimensional nature of symptom experience (e.g., frequency, severity and distress) and relevant symptom cluster among them is insufficient. To shed light on this understudied field, our study investigated the status of multiple psychosomatic symptoms among women and identified symptom clusters in different gestational stages.
Methods
A convenience sample of 557 pregnant women were recruited at two tertiary hospitals in Shandong, China. They were asked to complete the Memorial Symptom Assessment Scale, and sociodemographic and clinical information. Spearman correlation analysis, partial correlation networks, and hierarchical cluster analysis were carried out to identify optimal number of symptom clusters.
Results
Top five scores for symptoms in early pregnancy were nausea, lack of appetite, feeling drowsy, lack of energy, and vomiting; and weight gain, difficulty sleeping, sweating, lack of energy, and dry mouth scored highly in late pregnancy. Four clusters (pregnancy reaction symptom cluster, mood-fatigue symptom cluster, change in libido and food taste symptom cluster, and dry mouth-bloating symptom cluster) were identified in early pregnancy, and three clusters (mood-fatigue symptom cluster, sleep-bloating symptom cluster, and fluid deficiency symptom cluster) were determined in late pregnancy.
Conclusion
Women experience multiple psychosomatic symptoms during pregnancy, and the manifestation of symptoms varies in different stages. Our study has provided new insights into symptom clusters of pregnant women. These results might potentially support the development of assessment and management of multiple co-occurring symptoms in this population.
Acupuncture For The Treatment of Diarrhoea-Predominant Irritable Bowel Syndrome (ATIBS-D): A Pilot Randomized Controlled Trial
Authors: Qi Ling-Yu , Yang Jing-Wen , Yan Shi-Yan , Tu Jian-Feng , She Yan-Fen , Li Ying , Chi Li-Li , Wu Bang-Qi , Liu Cun-Zhi
Published: November 2021

Background: Diarrhoea-predominant irritable bowel syndrome (IBS-D) is a common disease without an established optimal treatment. Acupuncture has promising effects on IBS-D, but high-quality evidence is scarce.Methods: In this parallel, multicenter, randomized controlled trial, participants with IBS-D were assigned to three groups: specific acupoints (SA), non-specific acupoints (NSA) and non-acupoints (NA). Participants received 12 sessions (3 sessions per week) treatment over 4 weeks. The primary endpoint was a composite response rate at week 4 of treatment. An eligible composite responder was responded in both abdominal pain intensity and stool consistency, defined as at least 30% decrease in the weekly average of worst abdominal pain score and 50% or greater reduction in the number of Type 6 or 7 stool days weekly compared with baseline.Results: Of 201 screened patients with IBS-D, 90 (44.8%) patients were enrolled, and 88.9% patients completed this study (26 in NSA; 27 in SA and NA). The composite response rates at week 4 were 46.7%, 46.7% and 26.7% (P＞0.05) of the participants who received SA, NSA and NA acupuncture, respectively. Adverse events were reported in 2 (6.7%) patients in SA, 3 (10%) patients in NSA and NA. There were no serious adverse events.Conclusions: The present study suggests that acupuncture treatment is feasible and safe for IBS-D patients. The further adequately powered trials can be achieved by recruiting more patients, increasing treatment dose, prolonging follow-up, choosing specific acupoints, setting up sham-acupuncture control, or a combination thereof.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000030670. Registered on 9 March 2020. https://www.chictr.org.cn/edit.aspx?pid=50167&htm=4
Interfacial Shear at the Atomic Scale
Authors: Rejhon Martin , Lavini Francesco , Khosravi Ali , Shestopalov Mykhailo , Kunc Jan , Tosatti Erio , Riedo Elisa
Published: November 2021

Understanding the interfacial properties between an atomic layer and its substrate is of key interest at both the fundamental and technological level. From Fermi level pinning to strain engineering and superlubricity, the interaction between a single atomic layer and its substrate governs electronic, mechanical, and chemical properties of the layer-substrate system. Here, we measure the hardly accessible interfacial transverse shear modulus of an atomic layer on a substrate. We show that this key interfacial property is critically controlled by the chemistry, order, and structure of the atomic layer-substrate interface. In particular, the experiments demonstrate that the interfacial shear modulus of epitaxial graphene on SiC increases for bilayer films compared to monolayer films, and augments when hydrogen is intercalated between graphene and SiC. The increase in shear modulus for two layers compared to one layer is explained in terms of layer-layer and layer-substrate stacking order, whereas the increase with H-intercalation is correlated with the pinning induced by the H-atoms at the interface. Importantly, we also demonstrate that this modulus is a pivotal measurable property to control and predict sliding friction in supported two-dimensional materials. Indeed, we observe an inverse relationship between friction and interfacial shear modulus, which naturally emerges from simple friction models based on a point mass driven over a periodic potential. This inverse relation originates from a decreased dissipation in presence of large shear stiffness, which reduces the energy barrier for sliding.
High Quality Development of Comprehensive University Medical Education In China: Problems And Path In The New Era
Authors: Lv Shaochun , Song Hanjun , Cheng Lulu
Published: November 2021

Background: In the new era, the situation of medical education in China has undergone significant and profound changes. Medical universities not only carry the historical mission of providing multidisciplinary talent support for the modernization of education, but also are endowed with the tasks and requirements of holding high quality medical education and promoting the construction of Health China. Objective To state the theory of medical education in the new era, this paper analyzes the problems existing in medical education of China's comprehensive universities, and gives the countermeasures and ideas of medical education development. ﻿Method: By using literature research, illustrating with examples, conclusion and reasoning methods to analyze and illustrate.Result: This paper interprets the connotation of high-quality development of medical education in the new era, thinks about the current situation features of domestic medical education such as the multilateral exploration of management mode of comprehensive university medical education, lists the main problems in medical education, and discusses the ideas and countermeasures to solve these problems in the future.Conclusion: The reform and development of medical education need to further improve the top-level design, and obtain the understanding and support from stakeholders. The comprehensive university should consider putting medical personnel training in the vision of Health China construction. Under the guidance of the national macro policy of holding high-level undergraduate education, it is imperative to persist in problem-oriented principle and make efforts to reform, using information technology to promote the sharing of educational resources among schools and form a synergy in medical education.
High Efficiency Laser-Driven Proton Sources Using 3D-Printed Micro-Structure
Authors: Qin Chengyu , Zhang Hui , Li Shun , Wang Nengwen , Li Angxiao , Fan Lulin , Lu Xiaoming , Li Jinfeng , Xu Rongjie , Wang Cheng , Liang Xiaoyan , Leng Yuxin , Shen Baifei , Ji Liangliang , Li Ruxin
Published: November 2021

We applied 3D-printed microwire-array (MWA) structure to boost the energy conversion efficiency of laser proton acceleration. The advanced nano-printing technique allows precise control on the spacing and geometrical size of 3D structures at 100-500 nm resolution. Under irradiation of high contrast laser pulse (15J, 35fs), the MWA target generates over 1.2×1012 protons (> 1MeV) with cut-off energies extending to 25MeV, corresponding to top-end of 8.7% energy conversion efficiency from femtosecond lasers. When comparing to flat foils the efficiency is enhanced by three times, while the cut-off energy is increased by 30-70% depending on their thicknesses. By precisely controlling the array period via 3D nano-printing, we found the dependence of proton energy/conversion-efficiency on the spacing of the MWA. The experimental trend is well reproduced by hydrodynamic and Particle-In-Cell simulations, which reveal for the first time the modulation of pre-plasma profile induced by laser diffraction within the fine structures. Optimal geometry for laser-proton acceleration is therefore strongly modified. Our work validates the use of 3D-printed micro-structures to produce high efficiency laser-driven particle sources and pointed out the new effect in optimizing the experimental conditions.
Insecticidal and Enzyme Inhibition Activities of Leaf/bark Extracts, Fractions, Seed Oil and Isolated Compounds From Triadica Sebifera (L.) Small Against Aphis Craccivora Koch
Authors: Dolma Shudh Kirti , Singh Prithvi Pal , Reddy S. G. Eswara
Published: November 2021

Aphid, Aphis craccivora Koch (Hemiptera: Aphididae) is a major sap-sucking insect pest of leguminous crops and also transmit plant viruses leading to economic yield loss. Insecticidal activities of T. sebifera have not been reported against A. craccivora and other insect pests till date. In this study, residual toxicity of leaf/bark extracts, seed oil, fractions, isolated compounds and its combinations; synergistic activity of leaf/ bark extract with seed oil and its enzyme inhibition activities against A. craccivora was studied. Among extracts, ethanolic bark extract 80% (LC50=5115.98 mg L-1) was more effective against A. craccivora than other extracts. Among fractions, n-hexane fraction of leaf (LC50=425.73 mg L-1) and ethyl acetate fraction of bark (LC50=813.45mg L-1) was more effective. Among compounds, gallic acid was most effective (LC50=1303.68 mg L-1) than shikimic acid and quercetin (LC50=1725.09 and 1855.93 mg L-1, respectively). Seed oil (LC50=850.94 mg L-1) is more superior than extracts/fractions/compounds. All the combinations showed toxicity and synergistic activity. Leaf/bark extracts and seed oil (0.25-2 mg L-1) significantly inhibits the AChE and GST activity in A. craccivora. Based on field bio-efficacy studies, the leaf extract/seed oil or their combinations can be recommended for development of botanical formulation for the control of aphid.
Persisting Hypolipoproteinaemia Following Multiple Wasp Stings
Authors: Quan Zhenglin , Zeng Huanchao , Fang Zhicheng , Yang Xianyi
Published: November 2021

Background

Severe allergic reactions and life-threatening multiple organ injury or failure are common after severe stings. However, reports on wasp stings complicated with continual hypolipoproteinaemia are scarce in the literature and there is no consensus for its therapeutic management.
Methods

This case is a 49-year-old female patient who developed severe allergic reaction and multiple organ failure after severe wasp stings and complicated with sustained hypolipoproteinaemia. Her clinical characteristics and the change of lipid levels are described. During the hospitalization, we did not perform any intervention for dyslipidemia.
Results

The patient’s blood lipid levels were decreased after numerous wasp stings. In particular, the HDL-C was linear over all five days(nadir, 0.21mmol/L on day 5), and the level gradually recovered to normal till day 17. At the same time, the patient occurs severe inflammatory response and multiple organ dysfunction syndrome, especially liver failure. The 3 months follow-up of the patient was remarkable with normal lipid level and she was doing well in normal daily activities.
Conclusion

We highlight the hypolipoproteinaemia that might occur in the patient who after severe wasp stings. This study initially confirmed that there is some correlation between abnormal blood lipid metabolism and the evolution of the condition. Whether dyslipidemia in wasp stings is associated with hemolysis and inflammatory reaction is unclear, and further investigation would be required. As far as we know, this is the first report of persisting hypolipoproteinaemia after wasp stings. The clinical research and prolonged follow-up are yet to be concluded, and large-scale clinical studies need to be performed.
RPNs Levels are Prognostic and Diagnostic Markers for Hepatocellular Carcinoma
Authors: zheng Wangyang , Zheng Yuling , Bai Xue , Zhou Yongxu , Yu Liang , Ji Daolin , Leng Kaiming , Meng Nanfeng , Wang Hang , Huang ZiYue , Yam Judy Wai Ping , Xu Yi , Cui Yunfu
Published: November 2021

Background: Ribophorin family (RPNs) are important regulatory subunits of the proteasome. By influencing Ubiquitin-proteasome system activity, RPNs are responsible for almost all processes of physiology and pathology of mammalian cells. Nevertheless, little is known about the role of RPNs in HCC.Methods: In this work, using the online databases Oncomine, UCSC, Kaplan-Meier Plotter, UALCAN, cBioPortal, TIMER2, GeneMANIA,and STRING, we first evaluated the expression, diagnostic, prognostic, genetic alteration, immunity, gene network, and functional enrichment of RPNs in HCC. QPCR and western blot were used to detect RPN6 and RPN9 expressions in HCC tissues and cell lines. Then we performed studies to eveulated their functions in HCC cells proliferation, migration, and invasion in vitro. Results: All RPNs were surprisingly consistently upregulated in HCC tissues. Moreover, RPNs expression pattern is correlated with HCC tumor grade. RPN2, RPN3, RPN6, RPN9, RPN10, RPN11, and RPN12 have robust values in HCC diagnose. Then, survival analysis revealed that high expression of RPN1, RPN2, RPN4, RPN5, RPN6, RPN9, and RPN11were correlated with unfavorable HCC overall survival. Functional enrichment for RPNs, indicated that RPNs have many potential biosynthesis activities expert for UPS functions. Western blot, and qRT-PCR further verified these results in HCC tissues and cell lines. The silencing of RPN6 and RPN9 significantly influenced HCC cells' proliferation, migration, and invasion in vitro.Conclusions: RPN families functions as an important oncogene in HCC. RPN6 and RPN9 have the potential to be potential biomarkers and targets for HCC.
The Gratitude Mediates the Relationship Between Self-Esteem and Empathy Among Medical Students
Authors: Zhang Ying , Ou Yang , Ren Yanna
Published: November 2021

Background: One of the important parts of medical students' competence is empathy, which is believed to significantly influence patient satisfaction, clinical outcomes, and the sense of professional fulfillment. Objective: This study explored the potential mediating effect of gratitude on the relationship between self-esteem, cognitive empathy, and affective empathy, which may provide fundamental data for educational programs aiming to promote cognitive empathy and affective empathy. Design: The paper surveyed a total of 344 medical students with the Self-Esteem Scale, Gratitude Questionnaire-6, and the Chinese version of the Interpersonal Reactivity Index Scale. It uses descriptive analysis to determine the levels of self-esteem, gratitude, and empathy, and Pearson’s correlation to analyze correlations between them. It also conducts the pathway analysis with the equipment of structured equation modeling to test the mediating effect of gratitude on the association between self-esteem and empathy. Results: A total of 306 (88.95%) medical students completed the survey. It finds that, first, the levels of self-esteem, gratitude, cognitive empathy, and affective empathy are significantly correlated. Second, self-esteem has a direct, positive effect on cognitive empathy and affective empathy. Third, gratitude has a mediating role between self-esteem, cognitive empathy [b self-esteem - gratitude - cognitive empathy = 0.072, 95% CI = (0.013 to 0.131), p< 0.05], and affective empathy [bself-esteem - gratitude - affective empathy = 0.241, 95% CI = (0.018 to 0.134), p< 0.001]. Conclusion: Based on the role of self-esteem and gratitude in predicting cognitive empathy and affective empathy, this model can be used in the practice of clinical education to promote cognitive empathy and affective empathy in medical students.
Association between triglyceride glucose index and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross-sectional study
Authors: Li Hang , Lin Jie , Liu Yi ying , Liu Yao , Wan Qin
Published: November 2021

Background

Carotid atherosclerosis (CAS) lacks a simple and relatively accurate predictor. Triglyceride glucose (TyG) index is a simple indicator of insulin resistance, but the association between TyG index and CAS in patients with type 2 diabetes mellitus (T2DM) is less certain. This study aimed to investigate whether TyG index can predict CAS onset effectively.
Methods

In total, 1476 T2DM patients were included in cross-sectional analysis. TyG index (calculated by ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]) was split into tertiles (Tertile1-Tertile3). The main outcome was CAS prevalence as defined with carotid intima-media thickness (CIMT) ≥ 1.0 mm or carotid plaque. Logistic regression analysis was used to analyze the association between TyG index and CAS in patients with T2DM.
Results

In cross-sectional analysis, a total of 62.3% of T2DM patients had CAS, patients with a higher TyG index had a higher risk of CAS (χ2 = 13.856, P < 0.01). After confounder adjustment, patients with T2DM in the high tertile of TyG index had a greater risk to developing CAS than those in the low tertile (OR = 1.451, 95% CI =1.107-1.902, P = 0.007). Higher TyG index values were also associated with increased odds of CAS in patients with T2DM who were female, who were younger than 65 years old, who suffered from hypertension or obesity.
Conclusion

TyG index was significantly associated with CAS, suggesting that TyG index is a potential predictor for CAS in patients with T2DM.
Monolithic in-plane integration of gate-modulated switchable supercapacitors (ipG‐Cap)
Authors: Bräuniger Yannik , Lochmann Stefanie , Gellrich Christin , Galle Lydia , Grothe Julia , Kaskel Stefan
Published: November 2021

Monolithic integration of iontronic devices is a key challenge for future miniaturization and system integration, in particular the interconnection of multiple functional elements as required for ion computing. The G-Cap, a novel iontronic element, is a switchable supercapacitor with gating characteristics comparable to transistors in electronic circuits, but switching relies on ionic currents and ion electroadsorption. We report here the first monolithic in-plane G-Cap integration through 3D-inkjet printing of non-toxic nanoporous carbon precursors. The printed G-Cap has a three-electrode architecture integrating a symmetric "working" micro-supercapacitor (W-Cap) and a third "gate" electrode (G-electrode) that reversibly depletes/injects electrolyte ions into the system, effectively controlling the "working" capacitance. The printed precursor structures were directly converted into nanoporous carbon materials with a specific surface area of 544 m2 g−1. The symmetric W‐Cap operates with a proton conducting hydrogel electrolyte based on PVA/H2SO4 and shows a high capacitance (1.3 mF cm−2) that can be switched “on” and “off” by applying a DC bias potential (- 1.0 V) at the G-electrode. This effectively suppresses AC electroadsorption in the nanoporous carbon electrodes of the W-Cap, resulting in a high capacitance drop from an "on" to an "off" state. Printing offers far-reaching freedom of design for varying the device structure achieving superior device performance. The new monolithic structures achieve high rate performance, reversible on-off switching with an off-value as low as 0.5 % surpassing values reported so far. Establishing technologies and device architectures for functional ionic electroadsorption devices is crucial for diverse fields ranging from microelectronics and iontronics to biointerfacing and neuromodulation.
Synthesis and Crystal Structures of Novel Glycoluryl Carboxylic Acids Conglomerates
Authors: Baranov Vladimir V , Vol’khina Tatyana N , Kravchenko Angelina N
Published: November 2021

The two novel conglomerats were obtained by crystallization of racemic (S)-2-((3aS,6aR)- and (R)-2-((3aR,6aS)-2,5-dioxohexahydroimidazo[4,5-d]imidazole-1(2H)-yl)-3-methylbutanoic acids (racemate I), (R)-2-(3aR,6aR)- and (S)-2-((3aS,6aS)-4,6-dimethyl-2,5-dioxohexahydroimidazo[4,5-d]imidazole-1(2H)-yl)pentanoic acids (racemate II), which were synthesized by highly diastereoselective condensation of 4,5-dihydroxyimidazolidine-2-ones with racemic ureido acids for the first time. The differences in the molecular geometry of I and II are studied by X-ray diffraction that showed them to crystallize as conglomerates in non-centrosymmetric space groups Pna21 and P212121, respectively.
Quantum information for a solitonic particle with hyperbolic interaction
Authors: Moreira Allan Ranieri Pereira
Published: November 2021

In this work, we analyze a particle with position-dependent mass, with solitonic mass distribution in a stationary quantum system, for the particular case of the BenDaniel-Duke ordering, in a hyperbolic barrier potential. The kinetic energy ordering of BenDaniel-Duke guarantees the hermiticity of the Hamiltonian operator. We find the analytical solutions of the Schrödinger equation and their respective quantized energies. In addition, we calculate the Shannon entropy and Fisher information for the solutions in the case of the lowest energy states of the system.
Out of hospital cardiac arrest in Western Sydney - an analysis of outcomes and estimation of future eCPR eligibility
Authors: Chandru Pramod , Mitra Tatum Priyambada , Dhanekula Nitesh Dutt , Dennis Mark , Eslick Adam , Kruit Natalie , Coggins Andrew
Published: November 2021

Background
Refractory out of hospital cardiac arrest (OHCA) is associated with extremely poor outcomes. However, in selected patients extracorporeal cardiopulmonary resuscitation (eCPR) may be an effective rescue therapy, allowing time treat reversible causes. The primary goal was to estimate the potential future caseload of eCPR at historically 'low-volume' extracorporeal membrane oxygenation (ECMO) centres.
Methods
A 3-year observational study of OHCA presenting to the Emergency Department (ED of an urban referral centre without historical protocolised use of eCPR. Demographics and standard Utstein outcomes are reported. Further, an a priori analysis of each case for potential eCPR eligibility was conducted. A current eCPR selection criteria (from the 2-CHEER study) was used to determine eligibly.
Results
In the study window 248 eligible cardiac arrest cases were included in the OHCA registry. 30-day survival was 23.4% (n=58). The mean age of survivors was 55.4 years. 17 (6.8%) cases were deemed true refractory arrests and fulfilled the 2-CHEER eligibility criteria. The majority of these cases presented within “office hours” and no case obtained a return of spontaneous circulation standard advanced life support.
Conclusions
In this contemporary OHCA registry a significant number of refractory cases were deemed potential eCPR candidates reflecting a need for future interdisciplinary work to support delivery of this therapy.
Multi-omics Analyses Revealed Key Factors Involved in Fluorescent Carbon-Dots-Regulated Secondary Metabolism in Tetrastigma Hemsleyanum
Authors: Peng Xin , Xie Zhuomi , Wang Xiuhua , Zhao Yuxiang , Yang Chuyun , Zhang Zhongyi , Li Mingjie , Zheng Jianping , Wang Yuhui
Published: November 2021

Background: Luminescent nanomaterials (LNMs), especially newly-exploited fluorescent carbon-dots (CDs), have demonstrated promising candidates for sunlight harvesting and enhanced photosynthesis efficiency of crops. However, most of the studies focus on the design and synthesis of LNMs and primary metabolism in biomass acceleration, secondary metabolism that closely associated with the quality ingredients of plants is rarely mentioned. Results: UV-absorptive and water-soluble NIR-CDs were harvested via a facile microwave-assisted carbonization method. The effect and regulatory mechanism of NIR-CDs on the secondary metabolism and bioactive ingredients accumulation in Tetrastigma hemsleyanum were explored. A total of 191 differential secondary metabolites and 6874 differentially expressed genes were identified when the NIR-CDs were adopted for enhancing growth of T. hemsleyanum. The phenolic acids were generally improved, but the flavonoids were more likely to decrease. The pivotal differentially expressed genes were involved in biosynthesis of secondary metabolites, flavonoid biosynthesis, porphyrin and chlorophyll metabolism, etc. The gene-metabolite association was constructed and 44 hub genes highly related to quality ingredients accumulation and growth were identified, among which and the top 5 genes of the PPI network might be the key regulators.Conclusion: This research provided key regulatory genes and differentially accumulating quality ingredients under NIR-CDs-treatment, which could provide a theoretical basis for expanding the applications of nanomaterial in industrial crop agriculture.
Trends and Development in Clinical Research of FDA-Approved Drugs Against Interleukin-1β: A Bibliometric Analysis.
Authors: Tan Qi , Yang ZiMo , Chen Wenjuan , Jin Yang
Published: November 2021

Background

Interleukin(IL)-1β is a promising target for many diseases such as atherosclerosis, rheumatoid arthritis and cancer because it has been found to involve in the development of diseases. Anakinra, Canakinumab and Rilonacept were three Food and Drug Administration (FDA)-approved drugs and used for inhibiting IL-1β. Our study aims to access the trends and development for IL-1β inhibitors using bibliometric analysis.
Methods

All publication records were obtained from databases Web of Science and Pubmed. Publishing characteristics including organization, author, journals and co-authorship, Keywords, co-occurrence network, related journals network were analyzed by VOSviewer 1.6.16 (by Leiden University) and Bibliometric package in R(4.0.5). Graph prism 8 was used to performed descriptive analysis of all data.
Results

274 publications were enrolled in our study. Of the three drugs, anakinra has been extensively studied, with 130 publications related to it between 1997 and 2021. Clinical studies on IL-1β antagonists mainly focused on rheumatoid arthritis. Non-inflammatory diseases such as cardiovascular disease and cancer were also found in the related clinical research. The United States published the most articles in clinical research on IL-1β inhibitor and it was the country that participated in the most collaborations.
Conclusion

Targeting IL-1β was still a hot spot for clinical research in inflammatory diseases. As progresses are made in the field, Canakinumab and Rilonocept as two novel inhibitors, will increase in a similar trend to that of Anakinra. The number of studies about the inhibitors targeting IL-1β in inflammatory diseases will emerge more in the future. Cancer therapy might be the trend in the clinical studies of antagonizing IL-1β.
Empathy concerns enhance prosociality and modulate frontal theta oscillatory activity in young adults
Authors: Lavín Claudio , Soto-Icaza Patricia , López Vladimir , Billeke Pablo
Published: November 2021

Decision making is a process that can be strongly affected by social factors. Profuse evidence has shown how people deviate from traditional rational-choice predictions under different levels of social interactions. The emergence of prosocial decision making, defined as any action that is addressed to benefit another individual even at the expense of personal benefits, has been reported as an important example of such social influence. Furthermore, brain evidence has shown the involvement of structures such the prefrontal cortex, anterior insula and midcingulate cortex during decision settings in which a decision maker interacts with others under physical pain or distress or while being observed by others. Using a slightly modified version of the dictator game, we tested the hypothesis that the inclusion of another person into the decision setting increases prosocial decisions in young adults and that this increase is higher when the other person is associated with others in need. At the brain level, we hypothesized that the increase in prosocial decisions correlates with frontal theta activity as a marker of empathy saliency. The results showed that the inclusion of another person into the decision setting increased prosocial behavior only when this presence was associated with someone in need and that this was associated with an increase in frontocentral theta-oscillatory activity. These results suggest that the presence of someone in need enhances both empathy concerns and norm compliance, raising the participants’ prosocial decision making.
Liposuction in Cancer‐Related Lower Extremity Lymphedema: An Investigative Study For Clinical Applications
Authors: Xin Jianfeng , Sun Yuguang , Xia Song , Chang Kun , Dong Chao , Liu Zhong , Dong Jian , Shen Wenbin
Published: November 2021

Background: Lymphedema is a progressive, noncurable condition consisting of increases in subcutaneous fat and interstitial fluid in the limbs and fibrosis during later stages. The disease most commonly affects the limbs because of injury to or removal of lymph nodes. The aim of this study was to investigate therapeutic outcomes of liposuction for cancer-related lower extremity lymphedema.Methods: 62 patients with cancer-related lymphedema in unilateral lower extremity were recruited in this study, and all the patients underwent liposuction. The volume of hemorrhage and lipid, the operation time, and the volume changes of the affected extremity were compared by applying t-test, and the subjective feelings of patients were also assessed by applying Chi-square. Results: Total lipid volume is (2539±1253.5) ml, and the hemorrhage volume is (828±311.8) ml during liposuction. For the comparison of objective indexes, (1) Percent volume differences(PVDs) before surgery, in-operation and 3-month follow-up were (5.5±12.2 Vs. 11.6±18.4 Vs. 43.2±23.7, P＜0.05) respectively. (2) Higher lipid volume and liposuction rate for female patients, with a lower volume of hemorrhage. (3) Higher volume of hemorrhage in patients with a history of recurrent erysipelas. (4) Higher lipid volume and liposuction rate(LR), with lower hemorrhage for stage II than stage III patients. Conclusions: Liposuction is an effective therapy for cancer-related lower extremity lymphedema. Gender, stage and recurrent erysipelas history influence the course and effect of liposuction.
MicroRNA-155 Expression is Associated with Pulpitis Progression by Targeting SHIP1
Authors: Li Baishun , Guo Liyang , He Ying , Tu Xinran , Zhong Jialin , Guan Hongbing , Jiang Yiguo , Jiang Qianzhou
Published: November 2021

Pulpitis is a commonly seen oral inflammation condition in clinical practice, it can cause much pain for the patient and may induce infections in other systems. Much is still unknown for the pathogenic mechanism of pulpitis. In this work, we discovered that the expression of miR-155 was associated with dental pulpal inflammation both in vivo and in vitro. Experiments on odontoblast cell line MDPC-23 showed miR-155 could act as a positive regulator by increasing the production of pro-inflammatory cytokines IL-1β and IL-6 during inflammatory responses, whereas knockdown of miR-155 can reverse the effects. Bioinformatics analysis demonstrated that SHIP1 is a direct target of miR-155 in odontoblasts, this result was further verified at both mRNA and protein level. Inhibition of miR-155 resulted in the downregulation of inflammation factors, while co-transfection of si-SHIP1 and miR-155 inhibitor promoted the inflammatory responses. Treatment with miR-155 mimic or si-SHIP1 up-regulated the protein level of p-PI3K and p-AKT. By contrast, miR-155 inhibitor exerted the opposite effects. miR-155 mimics could upregulate the gene expression of IL-1β and IL-6. Co-transfection of LY294002 and miR-155 mimic attenuated the inflammatory responses. Consistent with in vitro results, miR-155−/− mice could alleviate inflammatory response, as well as decrease the activation of p-PI3K and p-AKT, whereas increase the activation of SHIP1. In conclusion, these data revealed a novel role for miR-155 in regulation of dental pulpal inflammatory response by targeting SHIP1 through PI3K/AKT signaling pathway.
An Integrated Modeling Scheme For Characterizing 3D Hydrogeological Heterogeneity of The New Jersey Shelf
Authors: Thomas Ariel Tremayne , von Harten Jan , Jusri Tomi Adriansyah , Reiche Sönke , Wellmann Florian
Published: November 2021

Continental shelves around the globe are hosts to vast reservoirs of offshore freshened groundwater. These systems show considerable complexity, often as a function of the geological heterogeneity. Data needed to characterise these systems are often sparse, and numerical models rely on generalized simplifications of the geological environment. In order to improve our understanding of these systems, it is necessary to implement modeling approaches that can produce large-scale geologically representative models using sparse data. We present an interdisciplinary stochastic modeling workflow incorporating borehole data, 2D depth-migrated seismic profiles, seismic attributes, and prior knowledge of the depositional setting. We generate a conditioned Gaussian field of porosity on the New Jersey shelf. We also perform a petrophysical conversion to a corresponding permeability distribution. The model dimensions are 134 km x 69 km x 1.7 km, with an adjustable resolution that can be adapted for process-based models of flow and solute transport. The integrated approach successfully translates small-scale porosity variations to a shelf-scale model that honors key characteristics of the New Jersey shelf wave-dominated depositional environment. The model was generated using open-source packages. All data and code to reproduce the complete workflow are provided along with this study so the model can be reproduced at any resolution for further studies of continental shelf processes offshore New Jersey.
Epidemiological Characteristics of Traumatic Spinal Cord Injury in Shaanxi, China
Authors: Wang Dong , Du Jinpeng , Hao Dingjun , Yan Liang , He Baorong , Zhao He , Ding Keyuan , Shi Haodong , Cao Yang , Qu Zechao , Huang Wangli , Feng Mingzhe
Published: November 2021

Study Design. A hospital-based retrospective epidemiological study.Summary of Background Data. TSCI is a highly disabling and deadly injury. Currently, there is little information regarding the epidemiological characteristics for TSCI in Shaanxi.Objective: To describe the demographic and epidemiological characteristics of patients with traumatic spinal cord injury (TSCI) in Shaanxi to help health-related institutions formulate corresponding measures.Methods. We retrospectively reviewed the medical records of the spine centers or orthopedic centers of the four cities in Shaanxi province according to the International Classification of Disease Version 10 (ICD-10) and diagnostic code of TSCI. Variables included gender, age, medical insurance, etiology, occupation, time of injury, level of injury, and severity of injury, multiple injury, treatment, and so on.Results: The study included the medical records of 694 patients with TSCI in 2018. The mean age of patients with TSCI was 48.4±14.9 years, and the male/female ratio was 3.45:1. The major causes of TSCI were high falls (40.2%) and low falls (26.7%). The most common injury site was the cervical spinal cord, accounting for 48.7%. The highest proportion of severity of injury was ASIA Grade D (37.8%). In addition, 74.6% of the patients had spinal fractures, the chest (38.0%) accounted for the highest proportion of all TSCI patients. Furthermore, 27.8% of the patients experienced clinical complications. 530 (76.4%) patients underwent surgery, 323 (46.5%) patients underwent inpatient rehabilitation.Conclusion: There are specific epidemiological characteristics of TSCI patients in Shaanxi, and preventive measures are suggested to be based on the characteristics of the different types of patients with TSCI and focused on high-risk groups.Level of Evidence: 3
Clinicopathological Features And Prognosis of Primary Pulmonary Rhabdomyosarcoma In The Middle-Aged And Elderly: A Case Report And Literature Review
Authors: Yingze Wei , Xiaoxia Jin , Jiatai Wang , Xinghua Zhu , Xudong Chen , Shuyun Yang
Published: November 2021

Background: Primary pulmonary rhabdomyosarcoma（PPRMS）in the middle-aged and elderly is a very rare event with only a few cases published. To date, only thirty-five cases of PPRMS in the middle-aged and elderly have been published. However, the analyses on clinicopathological characteristics and prognosis of PPRMS in the middle-aged and elderly have not been performed.Case presentation: We report an additional case of PPRMS in the middle-aged and elderly.Conclusions: PPRMS in the middle-aged and elderly was a highly malignant soft tissue tumor with obvious gender characteristics and significant age distribution. Pleomorphic rhabdomyosarcoma (RMS) was the most common subtype, with poor prognosis and significantly prolonged survival time after surgical resection.
Keeping An Eye On Environmental Quality in Tanzania as Trade, Industrialization, Income and Urbanization Continue To Grow
Authors: Byaro Mwoya , Mafwolo Gemma , Mayaya Hozen
Published: November 2021

By applying the ARDL (autoregressive distributed lag) bounds testing method, this study examines the short and long-term dynamic relationship between carbon dioxide (CO2) emissions, economic growth (Gross Domestic Product), industrialization, trade and urban population in Tanzania from 1990 to 2020. The study found that economic growth, trade, industrialization, and the urban population all contributed to the increase in environmental degradation (i.e. carbon dioxide emissions). However, we found that financial credit (i.e. domestic credit to the private sector) reduces carbon dioxide emissions, but its effects are not significant. Our findings revealed that economic growth (i.e. income) was responsible for both short and long-term increases in carbon dioxide emissions in Tanzania. Economic growth is harmful to the environmental quality above a threshold value of 6.23%. Our findings suggest that policy makers should monitor and use the threshold levels to manage carbon dioxide emissions and to protect the environmental quality. Further, a strong focus should be placed on formulating environmental policies (i.e. carbon tax policy) as industrialization, urban population, economic growth and trade continue to grow in future, restricting carbon dioxide emissions and safeguarding the environment.
Vom Krisenmodus zum Change-Prozess
Authors: Zinger Benjamin , Bröker Thomas , Lehmann Robert , Haberkern Carolyn , Lipot Sarah
Published: November 2021

Die Corona-Pandemie hat die Hochschulen in eine Krisensituation versetzt. Die damalige Entscheidung, das Sommersemester 2020 trotz Kontaktverboten durchzuführen, hat alle Hochschulen mobilisiert eine nahezu vollständige Online-Lösung aufzubauen. Diese ‹Zwangsdigitalisierung› hat Lehrende und Studierende in den folgenden Monaten in einen Experimentiermodus versetzt. Dass sich Lehrende und Lernende in dieser Breite mit digitalen Technologien auseinandersetzen und Erfahrungen machen, konnten bisherige Forderungen und Förderungen nicht erreichen. Es ist jedoch ungewiss, wie diese Dynamik in den Lehralltag einer Post-Pandemie-Zeit übertragen werden kann. Hier sind Hochschulen auf strategischer Ebene gefragt, den Krisenmodus für den Change-Prozess zu nutzen. Anhand einer Gruppendiskussion mit 14 Vizepräsidentinnen und Vizepräsidenten haben wir untersucht, welche langfristigen Veränderungspotenziale der Pandemie wahrgenommen werden. Durch eine strukturierte Inhaltsanalyse der Diskussion erweitern wir in diesem Beitrag die bisherigen zusammenfassenden Ergebnisse. Die Analyse zeigt, dass als entscheidende Variable für den Erfolg beim Krisenmanagement multiple agile Kooperationsformate zwischen den unterschiedlichen Ebenen und Akteuren wahrgenommen werden. Die Aufrechterhaltung und der Ausbau dieser Kooperationen kann die Grundlage für einen langfristigen Change-Prozess darstellen, der unabhängig von der CoViD-19-Pandemie notwendig ist.
Evaluating Postharvest Organic Nitrogen Fertilizer Applications in Early Fruiting Northern Highbush Blueberry
Authors: Bhasin Amit , Davenport Joan , Lukas Scott , Lu Qianwen , Hoheisel Gwen , DeVetter Lisa W.
Published: November 2021

Bloom to fruit maturity is a period of rapid growth and nitrogen (N) uptake in northern highbush blueberry (Vaccinium corymbosum L.). Sufficient plant-available N is critical during this time, and growers often accomplish this through fertilizer applications from bloom through fruit development. For organic production in northern climates like Washington State, postharvest applications of N fertilizer are not recommended for northern highbush blueberry because they may stimulate excessive vegetative growth, reduce floral bud set, and increase the risk of winter injury through delayed acclimation. However, early fruiting cultivars with the potential for an extended growing season after harvest may benefit from postharvest N applications because the additional N may promote shoot and root growth that could support fruit production in future years while still allowing plants to form floral buds and acclimate to winter temperatures. The objective of this study was to evaluate the potential impacts of postharvest organic N fertilizer applications on ‘Duke’, an early fruiting northern highbush blueberry cultivar. Specific objectives were to determine the effects of postharvest organic N fertilizer application on plant growth, yield, floral bud set, fruit quality, cold hardiness, tissue macronutrient concentrations, and select soil properties. Four treatments varying in the timing of N application were evaluated in a commercial ‘Duke’ field in eastern Washington using a single fertilizer rate of 130 kg⋅ha−1 N from 2018 to 2020. The organic fertilizer N source was a liquid fertilizer derived from digested plant materials. The experimental design was a randomized complete block design with four replications and treatments included the following: control (100% of N applied preharvest); 80/20 (80% preharvest, 20% postharvest); 70/30 (70% preharvest, 30% postharvest); and 60/40 (60% preharvest, 40% postharvest). Although the year influenced measured variables, including yield, floral bud set, fruit quality, tissue nutrients, and soil properties, few treatment effects were observed across the 3-year study. Cold hardiness was only impacted once (8 Feb. 2020), and floral buds were overall hardy to extreme minimum winter temperatures for the region. This project showed that applying postharvest organic N as a liquid fertilizer had no negative consequences on productivity metrics for an early fruiting blueberry cultivar grown in a region with an extended growing season, thus providing growers with more flexibility when timing their fertilizer applications. Results may differ for other fertilizer sources, and further monitoring of soil NO3-N accumulation should be conducted to gain a better understanding of its dynamics and the potential for risks.