bluuebunny/crossref_metadata_2025 huggingface dataset:
WAW-TACE: A Hepatocellular Carcinoma Multiphase CT Dataset with Segmentations, Radiomics Features, and Clinical Data
Authors: Bartnik Krzysztof , Bartczak Tomasz , Krzyziński Mateusz , Korzeniowski Krzysztof , Lamparski Krzysztof , Węgrzyn Piotr , Lam Eric , Bartkowiak Mateusz , Wróblewski Tadeusz , Mech Katarzyna , Januszewicz Magdalena , Biecek Przemysław
Published: October 2024

The WAW-TACE dataset contains baseline multiphase abdominal CT images from 233 treatment-naive patients with hepatocellular carcinoma treated with transarterial chemoembolization and includes 377 handcrafted liver tumor masks, automated segmentations of multiple internal organs, extracted radiomics features, and corresponding extensive clinical data. The dataset can be accessed at https://zenodo.org/records/12741586 .
Metabolic effects of medium-chain triacylglycerol consumption are preserved in obesity
Authors: Kanta Josephine M. , Lundsgaard Anne-Marie , Havelund Jesper F. , Armour Sara L. , Bæk Ole , Nguyen Duc Ninh , Richter Erik A. , Knudsen Jakob G. , Kleinert Maximilian , Færgeman Nils J. , Fritzen Andreas M. , Kiens Bente
Published: October 2024

We reveal that medium-chain triacylglycerol (MCT) intake increases postprandial ketogenesis and metabolic rate and reduces plasma glucose levels in humans. Notably, these responses persist in individuals with obesity and are maintained following chronic MCT supplementation. Some medium-chain fatty acids entered the circulation, suggesting that these, together with ketone bodies, act as signaling molecules/substrates in peripheral tissues. The findings highlight health beneficial effects of dietary MCT in individuals with obesity and reveal new insights into lipid biology.
The acute and chronic influence of exercise on mitochondrial dynamics in skeletal muscle
Authors: Ritenis Elya J. , Padilha Camila S. , Cooke Matthew B. , Stathis Christos G. , Philp Andrew , Camera Donny M.
Published: October 2024

Exercise and nutritional modulation are potent stimuli for eliciting increases in mitochondrial mass and function. Collectively, these beneficial adaptations are increasingly recognized to coincide with improvements in skeletal muscle health. Mitochondrial dynamics of fission and fusion are increasingly implicated as having a central role in mediating aspects of key organelle adaptations that are seen with exercise. Exercise-induced mitochondrial adaptation dynamics that have been implicated are 1) increases to mitochondrial turnover, resulting from elevated rates of mitochondrial synthesis (biogenesis) and degradative (mitophagy) processes and 2) morphological changes to the three-dimensional (3-D) tubular network, known as the mitochondrial reticulum, that mitochondria form in skeletal muscle. Notably, mitochondrial fission has also been implicated in coordinating increases in mitophagy, following acute exercise. Furthermore, increased fusion following exercise training promotes increased connectivity of the mitochondrial reticulum and is associated with improved metabolism and mitochondrial function. However, the molecular basis and fashion in which exercise infers beneficial mitochondrial adaptations through mitochondrial dynamics remains to be fully elucidated. This review attempts to highlight recent developments investigating the effects of exercise on mitochondrial dynamics, while attempting to offer a perspective of the methodological refinements and potential variables, such as substrate/glycogen availability, which should be considered going forward.
Circulating FGF‐23 Is Associated With Increased Risk of Osteoporosis and Fractures in Hemodialysis Patients: A Prospective Observational Study
Authors: Liu Dong , Yang Hongyan , Liao Qirong , Chang Baocao , Zhang Weiwei , Li Xiaoxiong , Li Jinping , Hou Mingliang , Ma Linqiu , Liu Yating , Lu Jing , Zhou Rui
Published: October 2024

Background and Objective: It is still controversial whether circulating fibroblast growth factor 23 (FGF‐23) can be used as a biomarker for the diagnosis of osteoporosis and fractures in patients with chronic kidney disease undergoing hemodialysis. We investigated the association of circulating FGF‐23 concentrations with an increased risk of osteoporosis and fractures of hemodialysis patients in the prospective study.

Methods: These data were collected in adult patients with hemodialysis in China from January 1 to December 30, 2016, and patients were followed up for 3.5 years. The association of circulating FGF‐23 with the risk of osteoporosis and fractures was analyzed by multivariate analysis.

Results: The study included 1788 hemodialysis patients, with a median age of 56 years (50–64 years) and a female population of 54.5%. Of 1788 patients, 389 (21.8%) developed osteoporosis and 207 (11.6%) developed fractures. High concentrations of FGF‐23 were significantly related to osteoporosis and fractures and were significantly related to different types of fractures (vertebral fractures, nonvertebral fractures, and hip fractures). Adjusted for all potential risk factors, high concentrations of FGF‐23 were associated with the risk of osteoporosis or fractures.

Conclusion: High concentrations of circulating FGF‐23 were associated with the risk of osteoporosis and fractures, including vertebral fractures and hip fractures. FGF‐23, along with bALP, CTX, and OC, may be used as a serum biomarker for predicting the risk of osteoporosis and fractures in patients with hemodialysis.
Evaluation of Sensory and Functional Compounds in Fermented Lactarius deliciosus Mushrooms
Authors: Venugopal Kavya , Satora Paweł , Bernaś Emilia
Published: October 2024

The effects of pretreatment and the addition of probiotic bacteria on the functional properties of fermented Lactarius deliciosus mushrooms were analyzed. Caps of L. deliciosus were blanched in water for 30 or 120 s (both at 96°C–98°C) or blanched in the microwave for 2 min (power 1000 W) as a pretreatment and fermented at 21°C and 26°C until pH ≤ 4.5 as a mark of successful fermentation. Lactobacillus acidophilus strain LA‐5 (Hansen) or Lactiplantibacillus plantarum strain SWA016 (Swanson) was added to the products to enrich the probiotic content. The type of pretreatment had a greater impact on the content of bioactive compounds in the products than fermentation temperature or the added probiotic bacteria. After fermentation, the pH of all products was below 4.5. Total dietary fiber (TDF) ranged from 45.74 ± 1.48 to 68.88 ± 2.84 g/100 g dm, and the highest content of TDF was observed in mushrooms blanched in water for 2 min. Beta‐glucans accounted for 30%–60% of TDF; mushrooms blanched in water for 30 s had the highest content of beta‐glucans (17.49 ± 0.46 to 30.38 ± 0.26 g/100 g dm) and phenolic compounds (1126.7 ± 52.2 to 1613.1 ± 40.4 mg/100 g dm), while microwave‐blanched mushrooms had the highest vitamin B1 (1.50 ± 0.08 to 2.78 ± 0.15 mg/100 g dm) and B2 (4.24 ± 0.38 to 7.58 ± 0.11 mg/100 g dm) contents. Water‐blanched mushrooms for 2 min scored the highest in the overall organoleptic analysis, and products with L. acidophilus strain LA‐5 (Hansen) were regarded as the most unfavorable. This study shows that fermented L. deliciosus exhibits nutraceutical properties and can be used in designing functional foods.
Indoor Air Quality: Predicting and Comparing Protective Behaviors in Germany and Portugal
Authors: Veiga Inês , Naranjo-Zolotov Mijail , Martins Ricardo , Oliveira Tiago , Karatzas Stylianos
Published: October 2024

This study investigates the adoption of indoor air quality (IAQ) management technologies in Germany and Portugal, focusing on the common and differentiating factors influencing individuals’ motivations and the perceived health impacts of these technologies. Utilizing a model based on the protection motivation theory, we surveyed 800 participants (400 from each country) to understand how their perceptions of the risks associated with poor IAQ and their evaluations of the effectiveness and costs of technologies like air purifiers and sensors drive the adoption intention of these technologies and well‐being of individuals. To estimate the complex relationships in our model, we employed partial least squares structural equation modeling (PLS‐SEM). Our model explains nearly 50% of the variance in well‐being for both countries. The results revealed significant differences in the factors driving technology adoption: Germans are primarily motivated by individual efficacy and personal responsibility with the people close to them. Regarding the similarities, participants from both countries value the technology’s effectiveness in improving IAQ and do not see being vulnerable to health issues derived from poor IAQ as a motivator. These insights highlight the need for strategies that are tailored to specific cultural and national contexts to promote the adoption of IAQ management technologies, aiming to enhance IAQ and public health outcomes.
Diabetes Mellitus Predicts Severe Respiratory Failure After Aortic Arch Replacement
Authors: Gambardella Ivancarmine , Worku Berhane , Lau Christopher , Tranbaugh Robert , Balaram Sandhya , Girardi Leonard
Published: October 2024

Objective: The lung is a target organ of diabetes mellitus (DM) via glycation of pulmonary elastin and collagen. In addition, hyperglycemia facilitates hypercapnic respiratory failure, which is instead mitigated by low‐carbohydrate high‐lipid (LC‐HL) nutrition. We sought to determine the association between diabetes and severe respiratory failure (SRF, i.e., need of reintubation\tracheostomy) after open aortic arch replacement (AAR).

Methods: Machine learning algorithms were evaluated for precision and recall (F2 score) and for clinical applicability to predict SRF. Conditional regression evaluated independent predictors of SRF after 1:2 propensity‐score matching.

Results: Information on diabetic status was available in 1275 patients undergoing AAR (1997–2023). Although support vector machine presented the highest F2 score (F2 = 0.337), conditional inference trees provided the most clinically applicable algorithm: diabetes was the best predictor of SRF, which occurred in 20/150 diabetics (13.3%) vs. 40/1125 nondiabetics (3.6%) (p < 0.01). In diabetics, left ventricular ejection fraction (LVEF) was the next best predictor of SRF, which occurred in 8/20 diabetics with LVEF ≤ 30% (40%) vs. 12/130 diabetics with LVEF >30% (9.2%) (p = 0.02). In nondiabetics, chronic obstructive pulmonary disease (COPD) was the next best predictor of respiratory failure, which occurred in 14/177 nondiabetics with COPD (7.9%) vs. 26/948 nondiabetics without COPD (2.7%) (p = 0.01). In the matched sample, diabetes was independently able to predict SRF (OR 2.20, 95% CI 1.10 | 4.42).

Conclusions: DM was the best predictor of SRF after AAR. Strict glycemic control and LC‐HL nutrition should be evaluated as measures to reduce postoperative SRF in diabetic patients.
Dairy Farmers’ Knowledge, Attitudes, and Practices (KAP) Towards Aflatoxin Contamination in Milk and Feeds in Bahir Dar, Ethiopia
Authors: Sewunet Sosina Dires , Kebede Elias , Melaku Achenef , Yirga Assefa Andnet , Alebie Atnaf , Assefa Aschalew , Ayalew Habtamu , Birhan Girma , Kenubih Ambaye Worku
Published: October 2024

Aflatoxins, primary foodborne mycotoxins, come from Aspergillus flavus and Aspergillus parasiticus fungi. They pose significant health risks to humans and animals, creating a major challenge in the dairy sector. The objective of this study is to evaluate the knowledge, attitudes, and practices (KAP) of dairy farmers regarding aflatoxin contamination in milk and feeds. Conducted as a cross‐sectional study in Bahir Dar city between November 2019 and February 2020, this investigation randomly selected 106 dairy farms for data collection. Face‐to‐face interviews, facilitated by a semistructured questionnaire, were employed. Findings indicate that 59.4% of respondents displayed good knowledge, while a substantial 94.3% exhibited a favorable attitude. Intriguingly, only 1.9% implemented good practices. Notably, the educational background of dairy farmers emerged as a significant factor influencing their KAP (p < 0.05). Conversely, various sociodemographic factors did not yield a significant impact on the KAP of dairy farmers. Despite a robust knowledge base and favorable attitudes towards aflatoxin among dairy farmers, the study highlights a significant gap in the implementation of recommended practices. This finding emphasizes the necessity for increased efforts to cultivate and reinforce good practices. Collaborative initiatives involving diverse stakeholders are crucial to reducing aflatoxin contamination in the dairy industry.
Relationship of Regular Laxative Use, Genetic Susceptibility of Depression, and Risk of Incident Depression in the General Population
Authors: Zhang Yuanyuan , Gan Xiaoqin , Zhou Chun , Ye Ziliang , He Panpan , Liu Mengyi , Zhang Yanjun , Yang Sisi , Qin Xianhui
Published: October 2024

Background: The relationship between laxative use and the risk of depression remains uncertain. We aimed to assess the prospective association of regular laxative use with the risk of incident depression and to examine whether genetic risk of depression modifies this association.

Methods: Four hundred fifty thousand forty‐five participants without depression at baseline and have complete information on laxative use from the UK Biobank were included. The study outcome was incident depression, derived from linkage to primary care records, hospital inpatient data, death register records, or self‐reported medical conditions at follow‐up visits.

Results: During a median follow‐up of 12.4 years, 18,651(4.1%) participants have developed depression. Regular laxative use was significantly associated with a higher risk of incident depression (vs. nonregular laxative use; adjusted hazard ratio [HR] = 1.78, 95% confidence interval [CI], 1.68–1.89). Genetic risk of depression did not significantly modify this association. The risk of incident depression increased with increasing types of laxatives used, with a HR of 1.89 (95%CI, 1.73–2.08) for use of single laxative type and 2.32 (95%CI, 1.82–2.96) for combined use of two or more laxative types (P for trend <0.001). The positive association between regular laxative use and incident depression was more pronounced in men (adjusted HR = 2.21, 95%CI, 1.96–2.48) versus women (adjusted HR = 1.67, 95%CI, 1.56–1.79; P interaction <0.001). Compared to those who did not use laxatives regularly and did not have constipation, participants who used laxatives regularly and had constipation had the highest risk of incident depression (adjusted HR = 2.33, 95%CI, 1.94–2.80).

Conclusions: Regular laxative use was significantly associated with a higher risk of incident depression, especially in men.
Balancing Progress and Preservation: The Complex Interplay of Economic Growth and Forest Conservation in Nepal’s Carbon Dioxide Emissions
Authors: Poudel Omkar , Acharya Pradeep , Chandra Kafle Sarad , Adhikari Basanta Prasad
Published: October 2024

The intricate relationship between economic growth, environmental quality, and energy consumption has been extensively debated and studied on a global scale. The impacts of ecological quality on economic growth have been observed to be both positive and negative, particularly about human health as a result of pollutant emissions. It is essential to examine the compatibility between economic growth and environmental improvement, particularly through the reduction of emissions. This study aimed to investigate the connection between economic growth in forested areas and the corresponding impact on carbon dioxide (CO2) emissions in Nepal (Rose and Fisher, 1970). The analysis utilized time series data from 1990 to 2020, employing the dynamic ordinary least squares (DOLS) method. The DOLS results demonstrated a positive and statistically significant relationship between economic growth and CO2 emissions (Shafik and Bandyopadhyay, 1992). Specifically, an increase of Rs. 10 million in gross domestic product (GDP) corresponded to a 0.6112 kiloton increase in CO2 emissions. In contrast, the long‐term coefficient for forested areas exhibited a substantial association, indicating that a reduction of one square kilometer of forested area (deforestation) resulted in an increase of 68.37 kilotons in CO2 emissions in Nepal. These findings accentuate the divergent effects of economic progress and deforestation on carbon emissions in Nepal, with GDP growth contributing to a greater increase in emissions. Therefore, the implementation of effective strategies and economic measures, such as afforestation and reforestation, forest protection, sustainable forest management, and mechanisms like REDD+ (reducing emissions from deforestation and forest degradation plus), can play a vital role in mitigating carbon emissions while simultaneously addressing deforestation and ensuring long‐term economic progress in Nepal.
A Rare Case of Giant Cystic Adenomatoid Tumor of the Uterus With Literature Review
Authors: Renavikar Pranav S. , Adwer Lina , Wagner David G. , Lele Subodh M.
Published: October 2024

Adenomatoid tumors are rare benign neoplasms arising from mesothelial cells, commonly found in the female genital system, particularly the uterus and fallopian tubes. The giant cystic variant of adenomatoid tumor is exceptionally rare and can cause massive growth mimicking malignant gynecological conditions. Histology and immunohistochemistry play a crucial role in confirming the diagnosis, with markers such as calretinin, D2‐40, CK7, BAP1, ER, and WT1 proving useful. A 51‐year‐old female with a history of breast cancer presented with pelvic pressure and vague pain. Imaging revealed an enlarged uterus with multiple heterogeneously enhancing masses and a predominantly cystic mass arising from the fundus, all believed to be leiomyomas. Surgical exploration and subsequent pathologic examination identified the cystic tumor as cystic adenomatoid tumor coexisting with leiomyomas, adenomyosis, and abdominal endometriosis. Diagnosing cystic adenomatoid tumor presents challenges, especially in patients with complex gynecologic histories. Cystic adenomatoid tumors typically have a favorable prognosis following surgical intervention. This case demonstrates one of the few reports of a giant cystic adenomatoid tumor (11.5 cm) and highlights diagnostic mimics. As these tumors are typically small and often seen only microscopically, the large size can confuse the pathologist who may be unaware of this feature leading to a misdiagnosis.
Development and Evaluation of Psychometric Properties of a Chinese Version Questionnaire for Measuring Emergency Nursing Interruptions
Authors: Lin Tao , Feng Xianqiong , Gao Yongli
Published: October 2024

Nursing interruptions occur frequently and often have adverse outcomes, threatening patient safety. Emergency departments have a high incidence of nursing interruptions owing to the concentration of critically ill patients and frequent emergencies. Current research mainly focuses on large hospitals and uses observation and interview methods. Therefore, there is a need to develop tools for measuring emergency nursing interruptions. This study develops a survey questionnaire on emergency nursing interruptions. It tests its validity and reliability by building on the conceptual framework of emergency nursing interruption proposed in the literature. Specifically, we develop a test version of the emergency nursing interruption survey questionnaire using a Delphi expert inquiry and preinvestigation. We selected 1047 emergency nurses in 22 provinces and autonomous regions of China to participate in the survey by completing the questionnaire between June and July 2023 to evaluate the validity and reliability of the questionnaire. The final questionnaire comprised 26 items across 5 dimensions—sources, types, interrupted nursing activities, consequences of interrupted nursing activities, and management of nursing interruptions. The content validity indexes were 0.948 at scale level and 0.842–1.000 at item level. We used exploratory factor analysis (EFA) to extract five common factors with a cumulative variance contribution rate of 66.550%. The results of the confirmatory factor analysis (CFA) demonstrated a good model fit. Cronbach’s α coefficient of the questionnaire was 0.912, split‐half reliability was 0.846, and the retest reliability calculated using the intraclass correlation coefficient was 0.915. To ensure the structural validity of the scales, EFA and CFA were conducted using two different datasets. Thus, the questionnaire showed good validity and reliability and can be used to evaluate how nurses understand emergency nursing interruptions.
Serological and Molecular Prevalence and Associated Risk Factors in Caprine Brucellosis, Northeastern Thailand
Authors: Rerkyusuke Sarinya , Lerk-u-suke Sawarin , Sukon Peerapol , Phuektes Patchara
Published: October 2024

Brucellosis is a significant zoonotic disease with global implications for animal and human public health. This study investigated the prevalence of caprine brucellosis in 39 meat goat herds in northeastern Thailand using serological and molecular methods. Seroprevalence, determined by the modified Rose Bengal test (mRBT), was negative, indicating no detectable antibodies against Brucella. However, real‐time PCR identified Brucella spp. DNA in 11 samples from 8 herds. Intraherd prevalence varied from 0.0% to 9.09%, averaging 6.73% (95% CI, 4.74–8.72). Univariate analysis revealed significant risk factors associated with brucellosis at the herd level. Larger herd size correlated with increased brucellosis odds ratio (OR: 6.30; 95% CI: 1.07–36.93; p = 0.041). Herds with multiple reproductive failures, including abortion, repeat breeding, and sterile, together with weak offspring, showed higher prevalence (OR: 9.37; 95% CI: 1.17–74.84; p = 0.034). Multivariable analysis identified herd sizes over thirteen as a significant risk factor (OR: 10.20; 95% CI: 1.06–97.40; p = 0.044). Notably, herds where owners were aware of direct transmission risks exhibited lower infection rates (OR: 0.05; 95% CI: 0.006–0.54; p = 0.012). This study underscores the complementary role of molecular techniques alongside serological tests in detecting Brucella infection accurately. The findings highlight the importance of effective herd management, reproductive health monitoring, and owner education in mitigating brucellosis transmission. Implementing robust control measures, including stringent biosecurity protocols and enhanced stakeholder awareness, is crucial for controlling brucellosis in meat goat populations.
Supplementary Figure 3 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER− Breast Cancer
Authors: Ridnour Lisa A. , Heinz William F. , Cheng Robert Y.S. , Wink Adelaide L. , Kedei Noemi , Pore Milind , Imtiaz Fatima , Femino Elise L. , Gonzalez Ana L. , Coutinho Leandro L. , Moffat Rebecca L. , Butcher Donna , Edmondson Elijah F. , Li Xiaoxian , Rangel Maria Cristina , Kinders Robert J. , Rittscher Jens , Lipkowitz Stanley , Wong Stephen T.C. , Anderson Stephen K. , McVicar Daniel W. , Glynn Sharon A. , Billiar Timothy R. , Chang Jenny C. , Hewitt Stephen M. , Ambs Stefan , Lockett Stephen J. , Wink David A.
Published: October 2024

Immune and tumor quantification
Near-Complete Reversal of Large Diffusion-Weighted Imaging Lesion after Thrombectomy: A Case Report and Literature Review
Authors: Dang Huy Quang , Nguyen Trung Quoc , Chiem Duc Nguyen , Le Tra Vu Son , Nguyen Ryan Anh-Quang , Nguyen Huy , Nguyen Thang Huy
Published: October 2024

Introduction: Diffusion-weighted imaging (DWI) plays a crucial role in acute ischemic stroke (AIS), as it is used to evaluate the ischemic lesions that are irreversibly damaged. The reversibility of DWI ischemic lesions has been noted in patients with AIS who undergo revascularization therapy. In addition, the occurrence of this phenomenon in large ischemic regions remains rare, particularly the near-complete reversal of large DWI lesion cases. Case Presentation: A 58-year-old male presented with a generalized tonic-clonic seizure. Emergent magnetic resonance imaging (MRI) revealed an extremely large infarction lesion in the right hemisphere with an Alberta Stroke Program Early Computed Tomographic Score (ASPECTS) value of 2 and occlusion of the terminal right internal carotid artery. The patient was immediately transferred to the Digital Subtraction Angiography (DSA) Unit for endovascular treatment with a stent retriever. After a rapid successful reperfusion with expanded treatment in cerebral infarction (eTICI) score of 3, the patient promptly recovered 24 h after the procedure. A brain MRI was repeated after 8 days of admission, and interestingly, the DWI lesion showed significant reversal. The modified Rankin scale (mRS) at discharge was 2 and 1 at 90-day follow-up, respectively. Conclusions: Our case shows that the reversibility of DWI ischemic lesions can occur during the acute stroke phase, even in patients with extremely large regions, if rapid and successful reperfusion is achieved. The clinical implications of this phenomenon indicate that using DWI to evaluate the infarct core should be interpreted with caution.
New-Onset Complement-Mediated Thrombotic Microangiopathy during the COVID-19 Pandemic
Authors: Aigner Christof , Gaggl Martina , Schmidt Sophie , Kain Renate , Kozakowski Nicolas , Oszwald André , Prohászka Zoltán , Sunder-Plassmann Raute , Schmidt Alice , Sunder-Plassmann Gere
Published: October 2024

Introduction: The coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus is alleged to enable a proinflammatory state that leads to the activation of the coagulation and the complement cascade. In this study, we aimed to establish the impact of the COVID-19 pandemic on patients with new onset of cTMA/aHUS in the Vienna TMA cohort and whether COVID-19 or SARS-CoV-2 vaccinations would pose a greater risk of initial manifestation of cTMA/aHUS. Methods: We used the Vienna TMA cohort database to examine the prevalence of COVID-19-related and of SARS-CoV-2 vaccination-related aHUS/cTMA during the first 3 years of the COVID-19 pandemic in a large single-centre cohort. Results: Between March 2020 and May 2023, a total of 7 patients experienced their first aHUS/cTMA episode. No patient experienced a TMA relapse or more than one episode during the follow-up period. Three TMA episodes were attributable to either COVID-19 (n = 1; 33%) or SARS-CoV-2 vaccination (n = 2; 66%), respectively. All 3 patients had systemic signs of TMA, and TMA was confirmed by kidney biopsy in all cases. Among the 7 patients, we recorded five infections that triggered one TMA episode (20%) and 19 vaccinations triggered two TMA episodes (10%; p = 0.52, odds ratio 0.47; 95% CI: 0.04–8.39). Conclusion: We speculate that both SARS-CoV-2 vaccinations and COVID-19 episodes can represent a triggering factor for aHUS/cTMA episodes in (genetically) vulnerable individuals. However, COVID-19 might have a stronger association and might be a stronger trigger than the SARS-CoV-2 vaccines. The incidence of new aHUS cases did not differ from the pre-pandemic era in a large tertiary care centre cohort.
Hypoxia Reduces Mouse Urine Output via HIF1α-Mediated Upregulation of Renal AQP1
Authors: Qiao Rongfang , Cui Xiaohui , Hu Yitong , Wei Haoqing , Xu Hu , Zhang Cong , Du Chunxiu , Chang Jiazhen , Li Yaqing , Ming Wenhua , Qi Yinghui , Guan Youfei , Zhang Xiaoyan
Published: October 2024

Introduction: Patients with acute mountain sickness (AMS) due to hypoxia at high altitudes often exhibit abnormal water metabolism. Hypoxia-inducible factors (HIFs) are major regulators of adaptive responses to hypoxia. As transcription factors, HIFs are involved in the regulation of erythropoiesis, iron metabolism, angiogenesis, energy metabolism, and cell survival by promoting the transcriptional expression of hundreds of target genes. Roxadustat, a novel drug for the treatment of anemia associated with chronic kidney disease (CKD), acts by inhibiting the degradation of HIFs to increase their protein levels. However, the clinical use of roxadustat is frequently associated with peripheral edema, suggesting the involvement of HIFs in regulating the body’s water balance possibly by modulating water reabsorption in the kidney. Methods: We first evaluated the effect of hypoxia (8% O2) on mouse urine output. We then performed in vitro experiments using hypoxia (1% O2) and roxadustat on mouse primary proximal tubular cells (mPTCs). The quantitative polymerase chain reaction, Western blot, and immunofluorescence were used to assess AQP1 mRNA and protein expression levels. Luciferase, Chromatin immunoprecipitation (ChIP), and electrophoretic mobility shift assay (EMSA) were used to investigate the transcriptional regulation of AQP1 by HIF1α. Results: We found that mice exposed to hypoxia (8% O2) had significantly reduced urine volume compared to mice exposed to normoxia (21% O2). Hypoxia significantly elevated AQP1 expression at both mRNA and protein levels. In vitro experiments using mouse primary cultured proximal tubular cells (mPTCs) revealed that both hypoxia and roxadustat increased AQP1 expression. Mechanistically, overexpression of HIF1α, but not HIF2α, markedly increased AQP1 protein expression. Furthermore, the upregulation of AQP1 by hypoxia and roxadustat can be blocked by the HIF1α inhibitor PX-478 in mPTCs. Finally, we found that the AQP1 gene promoter contains a putative hypoxia response element and confirmed that AQP1 is a target gene of HIF1α using Luciferase reporter, ChIP, and EMSA assays. Conclusion: This study demonstrates that hypoxia can reduce the urine volume of mice via upregulating AQP1 expression by HIF1α in the proximal tubular epithelial cells. Our findings also suggest a potential mechanism involved in water metabolism disorders in patients with AMS and in patients with CKD receiving roxadustat treatment.
Development of an Artificial Intelligence System for Distinguishing Malignant from Benign Soft-Tissue Tumors Using Contrast-Enhanced MR Images
Authors: Hirozane Toru , Hashimoto Masahiro , Haque Hasnine , Arita Yuki , Mori Tomoaki , Asano Naofumi , Nakayama Robert , Morii Takeshi , Hosogane Naobumi , Matsumoto Morio , Nakamura Masaya , Jinzaki Masahiro
Published: October 2024

Introduction: The integration of artificial intelligence (AI) into orthopedics has enhanced the diagnosis of various conditions; however, its use in diagnosing soft-tissue tumors remains limited owing to its complexity. This study aimed to develop and assess an AI-driven diagnostic support system for magnetic resonance imaging (MRI)-based soft-tissue tumor diagnosis, potentially improving accuracy and aiding radiologists and orthopedic surgeons. Methods: An experienced orthopedic oncologist and radiologist annotated 720 images from 77 cases (41 benign and 36 malignant soft-tissue tumors). Eleven tumor subtypes were identified and classified into benign and malignant groups based on histological diagnosis. Utilizing the standard machine learning classifier pipeline, we examined and down-selected imaging protocols and their predominant radiomic features within the tumor’s three-dimensional region to differentiate between benign and malignant tumors. Among the scan protocols, contrast-enhanced T1-weighted fat-suppressed images showed the most accurate classification based on radiomic features. We focused on the two-dimensional features from the largest tumor boundary surface and its neighboring slices, leveraging texture-based radiomic and deep convolutional neural network features from a pretrained VGG19 model. Results: The test data comprised 44 contrast-enhanced images (22 benign and 22 malignant soft-tissue tumors) containing six malignant and five benign subtypes distinct from the training data. We compared expert and nonexpert human performances against AI by assessing malignancy detection and the time required for classification. The AI model showed comparable accuracy (AUC 0.91) to that of radiologists (AUC 0.83) and orthopedic surgeons (AUC 0.73). Notably, the AI model processed data approximately 400 times faster than its human counterparts, showcasing its capacity to significantly boost diagnostic efficiency. Conclusion: We developed an AI-driven diagnostic support system for MRI-based soft-tissue tumor diagnosis. While additional refinement is necessary for clinical applications, our system has exhibited promising potential in differentiating between benign and malignant soft-tissue tumors based on MRI.
Optimizing classification models for medical image diagnosis: a comparative analysis on multi-class datasets
Authors: Rachman Manga Abdul , Putri Utami Aulia , Azis Huzain , Salim Yulita , Faradibah Amaliah
Published: October 2024

The surge in machine learning (ML) and artificial intelligence has revolutionized medical diagnosis, utilizing data from chest ct-scans, COVID-19, lung cancer, brain tumor, and alzheimer parkinson diseases. However, the intricate nature of medical data necessitates robust classification models. This study compares support vector machine (SVM), naïve Bayes, k-nearest neighbors (K-NN), artificial neural networks (ANN), and stochastic gradient descent on multi-class medical datasets, employing data collection, Canny image segmentation, hu moment feature extraction, and oversampling/under-sampling for data balancing. Classification algorithms are assessed via 5-fold cross-validation for accuracy, precision, recall, and F-measure. Results indicate variable model performance depending on datasets and sampling strategies. SVM, K-NN, ANN, and SGD demonstrate superior performance on specific datasets, achieving accuracies between 0.49 to 0.57. Conversely, naïve Bayes exhibits limitations, achieving precision levels of 0.46 to 0.47 on certain datasets. The efficacy of oversampling and under-sampling techniques in improving classification accuracy varies inconsistently. These findings aid medical practitioners and researchers in selecting suitable models for diagnostic applications.
Analysis of ensemble machine learning classification comparison on the skin cancer MNIST dataset
Authors: Belluano Poetri Lestari Lokapitasari , Rahma Reyna Aprilia , Darwis Herdianti , Rachman Manga Abdul
Published: October 2024

This study aims to analyze the performance of various ensemble machine learning methods, such as Adaboost, Bagging, and Stacking, in the context of skin cancer classification using the skin cancer MNIST dataset. We also evaluate the impact of handling dataset imbalance on the classification model’s performance by applying imbalanced data methods such as random under sampling (RUS), random over sampling (ROS), synthetic minority over-sampling technique (SMOTE), and synthetic minority over-sampling technique with edited nearest neighbor (SMOTEENN). The research findings indicate that Adaboost is effective in addressing data imbalance, while imbalanced data methods can significantly improve accuracy. However, the selection of imbalanced data methods should be carefully tailored to the dataset characteristics and clinical objectives. In conclusion, addressing data imbalance can enhance skin cancer classification accuracy, with Adaboost being an exception that shows a decrease in accuracy after applying imbalanced data methods.
Unraveling Indonesian heritage through pattern recognition using YOLOv5
Authors: Rosalina Rosalina , Sahuri Genta
Published: October 2024

This research focuses on three iconic Indonesian batik patterns-Kawung, Mega Mendung, and Parang-due to their cultural significance and recognition. Kawung symbolizes harmony, Mega Mendung represents power, and Parang signifies protection and spiritual power. Using the YOLOv5 deep learning model, the study aimed to accurately identify these patterns. Results showed mean average precision (mAP) scores of 77% for Kawung, 80% for Parang, and an impressive 99% for Mega Mendung. The highest precision results were 91% for Kawung, 88% for Parang, and 77% for Mega Mendung. These findings highlight the potential of pattern recognition in preserving cultural heritage. Understanding these designs contributes to the appreciation of Indonesia s culture. The research suggests applications in cultural studies, digital archiving, and the textile industry, ensuring the legacy of these patterns endures.
Parliament Hidden in Small Streets and Squares
Authors: Preuss Ondřej
Published: October 2024

Parliament is the space where politics and (constitutional) law literally take shape. Here, collective decisions take form in a specific setting where relationships between various political actors are organized through architecture. The architecture of spaces of political congregation is not only an abstract expression of a political culture – it participates in politics and it is part of the constitutional system.

This paper focuses on the question, whether the location (and architecture) of the seat of the parliament is somehow significant for decision-making practices and for the role of the parliament in the constitutional system and for its values.

This is discussed based on the example of the seat of the Parliament of the Czech Republic. The parliament (and especially the Chamber of Deputies) is one of the key institutions in Czech constitutional system. This is kind of paradox, because unlike other significant parliaments, the buildings of the Parliament of the Czech Republic are not dominant of the city of Prague.
From the periphery to the centre: Protestantism and Korean identity in the north-west region
Authors: Park Eun-Young
Published: October 2024

In late 19th-century Korea, Protestantism was perceived as a symbol of western civilization and a messenger for western-style modernity. It was also accepted within the framework of a clash between civilizations, a confrontation of power against power. In such a context, traditional elements were seen as something to be discarded, while western-style modernity, including Protestantism, became the object of aspiration. As is well recognized, the ‘north-west region’ of Korea emerged as the cradle and most vibrant epicentre for the reception of Protestantism, outpacing other regions in terms of both rapid qualitative and quantitative growth within a short time frame. This raises the question: Why did Protestantism receive such an active and passionate welcome in the north-western region? As part of a case study, this article focuses on Pyeongan Province and explores how the encounter between the north-western region and Protestantism reshaped the pre-existing ‘identity’ of north-westerners. In essence, the reason why the people of the north-west region embraced Protestantism more actively compared to other regions was twofold: first, due to their long-standing aspiration to move towards the centre, which had persisted from the past, and, second, because the Protestantism introduced to this region had a mutual affinity with the north-western people. This can be considered as the factor that enabled the rise of north-western people in the early modern period.
Risk-contamination and Dilution: Advancing the RNR Model in Prison Settings
Authors: Allen-Flores Baylee , Hamilton Zachary , Ursino John , Kigerl Alex
Published: October 2024

The Risk-Needs-Responsivity (RNR) model posits separating lower from higher-risk individuals to avoid “risk contamination.” In a prison setting, policies and restrictions lead to mixing different populations within a housing unit. While this may pose a threat, it may allow higher-risk individuals to gradually promote through security levels, reducing risk. We term this “risk dilution.” The current study compares the infraction behavior of individuals that are over-classified (housed higher than their risk) and those under-classified (housed lower than their risk). Using mixed-effect models with a large ( N = 52,000) sample of incarcerated men, findings demonstrate support for both contamination and dilution. Policy implications identify the impact of these two processes on overcrowded prisons and the consolidation of housing units post decarceration.
Depressive symptoms and associated socioeconomic and clinic factors: Three different years data from Türkiye
Authors: Özdin Selçuk , Laçiner Kerem , Böke Ömer , Aker Servet
Published: October 2024

Background:

Depression is one of the main diseases that cause disability. It is more common in various sociodemographic situations.

Aims:

This study investigated the risk factors associated with depressive symptoms and changes over the years based on data from a sample from the Republic of Türkiye. It was also intended to compare depressive symptoms and inflation rates by years.

Method:

Data for 2016, 2019 and 2022 from the Turkish Health Survey performed by the Turkish Statistical Institute were used in the study. Data for age, sex, marital status, education level, employment status, accompanying chronic health problems, restrictions in daily activities associated with health problems and problems accessing psychological treatment due to difficulty in paying were evaluated in terms of depressive symptoms.

Results:

Higher depressive symptoms were determined in women, the widowed and divorced, individuals with a low level of education, the unemployed, individuals with chronic health problems, those with restrictions in daily activities associated with chronic health problems and those with problems accessing psychological treatment due to difficulty in paying. Although inflation rates increased over the years, the severity of depressive symptoms decreased. A moderate positive correlation was observed between depressive symptoms and basic activities of daily living.

Conclusions:

Developing policies aimed at groups with high depressive symptoms may be important in combating depression.
From Displacement to Marginalization: Tonga-Goba Wartime Experiences in the Mid-Zambezi Valley, 1976–1979
Authors: Matanzima Joshua , Nyachega Nicholas
Published: October 2024

In the 1970s, the Zimbabwe People’s Revolutionary Army (ZIPRA) opened its bases in the mid-Zambezi Valley, at Paradise and Mayovhe, under Chief Mola’s territory. This move by ZIPRA was motivated by a variety of reasons. The most important fact was that the Tonga-Goba people of this region were ready to support the war because they wanted to regain control of the riverscape from which they were displaced by the colonial state during the late 1950s when the Kariba dam was constructed. This paper examines how the colonial displacements of the Tonga-Goba people, their marginalization as well as the colonial regime’s “broken promise” all shaped their participation in the Zimbabwe War of Liberation in the 1970s. To explore this history of war from below, our study builds largely from the local Tonga-Goba narratives.
Trends and Factors Associated With Extremity Fractures and Post-Acute Care Utilization of Nevada Older Adults: Insights of Age-Friendly State Planning in U.S.
Authors: Kang Soo Hwan , Shen Jay J. , Kim Yonsu , Ioanitoaia-Chaudhry Iulia , Lee Se Won , Chung Tae Ha , Choe Ian , Jeong Connor , Kwon Songe , Lim Daniel , Hwang Yena , Frimer Leora , Yoo Ji Won
Published: October 2024

Along with the trend of a steady utilization decline in the U.S. nursing home beds, post-acute care (PAC) utilization at the skilled nursing facilities has declined. This study was a cross-sectional, retrospective review of hospital discharge-based claim data. We evaluate the factors associated with utilizing post-acute care at rehabilitation facilities among those with extremity fractures in the state of Nevada. All Nevada hospital discharges of aged ≥65 years with extremity fractures between 2018 and 2021 were divided to post-acute care locations by (1) rehabilitation facilities (skilled nursing facility and inpatient rehabilitation facility) and (2) homes (with and without services). PAC utilization at facilities declined from 55.1% in 2018 to 49.7% in 2021 ( P < .001). In response, PAC utilization at homes continuously upwards, particularly, homes with services from 18.8% in 2018 to 24.5% in 2021 ( P < .001). Older age, female, lower extremity fractures, comorbidities, and Medicare beneficiaries were associated with higher probabilities of utilizing post-acute rehabilitation facilities. Racial minorities, COVID-19 pandemic, upper extremities, Medicaid beneficiaries, rural hospitals, and prolonged hospital length of stay were associated with lower probabilities of PAC utilization at facilities. Caregiver burdens and workforce training is urgently warranted to respond to this utilization shift. Effective geriatrics workforce training might advance care efficiency of older adults with extremity fractures and guide to the insights of establishing the age-friendly state of Nevada in response to this utilization shift trends.
Investigation of Body Perception, Alexithymic Characteristics, and Self-Esteem in Patients Underwent Septorhinoplasty
Authors: Yagci Tarik , Gunay Yagci Zehra
Published: October 2024

Objective: This study evaluated patients’ body perception, self-esteem, and personality traits during the preoperative and postoperative periods of septorhinoplasty. Based on these evaluations, we may provide patient selection recommendations for septorhinoplasty applicants. Methods: In this cross-sectional questionnaire study, 86 patients who underwent primary septorhinoplasty in the Department of Otolaryngology at Bilecik Training and Research Hospital were included between March 2023 and 2024. The same surgeon performed all operations. The preoperative Rhinoplasty Outcome Evaluation (ROE) Questionnaire, Rosenberg Self-Esteem Scale (RSES), Body Perception Scale (BPS), Toronto Alexithymia Scale (TAS), and TEMPS-A Temperament Scale in the preoperative period and ROE, RSES, and BPS in the postoperative period were applied. Results: Fifty-four female and 32 male patients participated in our study. The mean age was 24.0 ± 0.6 years. While there was no significant difference in the BPS and RSES scores between the preoperative and postoperative periods, the total ROE score was significantly higher in the postoperative than in the preoperative period. Postoperative ROE scores were positively correlated with RSES and hyperthymic temperament. In contrast, it was negatively correlated with depressive temperament, cyclothymic temperament, anxious temperament, BPS total score, TAS total score, and TAS emotion recognition and expression subscale scores. In the group with alexithymia features separated according to the TAS cutoff score, preoperative and postoperative ROE results were significantly lower, whereas depressive, cyclothymic, irritable, and anxious personality traits and total BPS scores were higher. However, the postoperative RSBE scores were lower in this group. Conclusion: This is the first study to evaluate self-esteem, body image, alexithymia, and personality traits in septorhinoplasty patients. Appropriate patient selection is essential for success and patient satisfaction in aesthetic operations such as septorhinoplasty. Performing BPS, TEMPS-A, and TAS may help evaluate psychological factors.
Artificial Intelligence (AI) and Saudi Arabia’s Governance
Authors: Ibrahim Nayera Mohamed Hamed
Published: October 2024

Why does the Saudi government utilize artificial intelligence? The research questions whether the more the Saudi government utilizes artificial intelligence (AI), the more it endures authoritarianism or not. In fact, an analytical research design based on a neo-institutional approach is applied to the case study. The research examines the concept of isomorphism by addressing the motivations for AI utilization in Saudi Arabia, the outcomes of AI on Saudi Arabia’s authoritarian practices, Saudi citizens’ insights into AI applications in Saudi Arabia, the relationship between legitimacy and stability in the presence of AI in Saudi Arabia, and the impact of culture and cognitive bases on Saudi organizational behavior toward AI in Saudi Arabia. The research concludes the following: Saudi Arabia applies artificial intelligence to keep the political sphere unchangeable. In other words, the more the Saudi government utilizes artificial intelligence, the more it becomes a digital authoritarian tool.