bluuebunny/crossref_metadata_2025 huggingface dataset:
‘Let the System Do Its Job and Families Handle the Rest’? Protective and Risk Factors Contributing to Pandemic Crisis Parental Burnout
Authors: Szałachowski Roman Ryszard , Tuszyńska-Bogucka Wioletta , Bogucki Jacek
Published: January 2025

Background: The work main purposes were to identify the sources of problems and demands causing parental burnout and to specify the resources/support factors during the COVID-19 pandemic. The study was based on the Balance Theory of Risk and Support/Resource Factors (BR2 Model) by Mikolajczak and Roskam. Methods: The study explored the predictive value of socio-economic variables, religiosity, the meaning of life, positivity, perceived social support, family functionality, and balance between risks and resources in parental burnout using the structural equation modelling method on a sample of 337 parents. Results: The presence of children’s learning difficulties and behavioural problems are the most important risk factors and aggravate parental burnout, and the presence of a meaning of life, support coming from the family, family affection, and relationship lengths are the main protective resources, allowing parental burnout to decrease during the pandemic crisis. Conclusions: The findings are instructive for both theory and practice. The study successfully operationalised the BR2 model—the model obtained from the path analysis fits well, confirms the structure of parental burnout theory, and demonstrates the appropriateness of the application of BR2 theory in crisis conditions. The most effective way to help parents in a crisis situation is (in addition to psychological support) the effective provision of specialist help for children, resulting in a reduced risk of an unfavourable balance between demands and family resources. The family- or parent-oriented interventions that address professional help in problems with children can be the most effective at reducing the negative consequences of a pandemic on children and their parents. The COVID-19 pandemic has shown the importance of investing in healthcare infrastructures.
Diagnostic Cut-Off Values Based on Lipid Layer Pattern for Dry Eye Disease Subtypes Assessment
Authors: Sabucedo-Villamarin Belen , Garcia-Queiruga Jacobo , Pena-Verdeal Hugo , Garcia-Resua Carlos , Yebra-Pimentel Eva , Giraldez Maria J.
Published: January 2025

Background: The aim of the present study was to establish a cut-off value of the Lipid Layer Pattern (LLP) between participants with different subtypes of Dry Eye Disease (DED) including Deficient Dry Eye (ADDE), Evaporative Dry Eye (EDE), and Mixed Dry Eye (MDE). Methods: 240 participants diagnosed with DED according to the Tear Film and Ocular Surface Society in the Dry Eye Workshop II guidelines were included in the study. Tear Meniscus Height (TMH) using the Tearscope illumination and Meibomian Gland Loss Area (MGLA) using the Keratograph 5M were assessed to categorize the participants into an ADDE group, EDE group, or MDE group. Then, the LLP was assessed using the Tearscope following the Guillon (LLP-G) and Colour (LLP-C) schemes. Results: Receiver Operating Characteristics (ROC) showed that both LLP-G and LLP-C have no diagnostic potential in distinguishing between ADDE and EDE participants (both p ≥ 0.724). However, to differentiate the ADDE participants from the MDE, ROC procedures showed a good diagnostic potential with cut-off values of Closed Meshwork-Wave (AUC ± SD = 0.609 ± 0.049, p = 0.038, sensitivity: 23.9%; specificity: 76.1%) and Grey-White (AUC ± SD = 0.611 ± 0.050, p = 0.034, sensitivity: 40.7%; specificity: 73.9%) for LLP-G and LLP-C, respectively. Also, a significant potential to distinguish between the EDE from MDE participants was found, with cut-off values of Closed Meshwork (AUC ± SD = 0.604 ± 0.049, p = 0.043, sensitivity: 40.8%; specificity: 76.1%) and Grey-White (AUC ± SD = 0.604 ± 0.051, p = 0.038, sensitivity: 44.7%; specificity: 73.9%) for LLP-G and LLP-C, respectively. Conclusions: Using the Tearscope, both LLP-G and LLP-C has diagnostic potential to distinguish MDE participants from the other subtypes of DED.
Neurogenic Orthostatic Hypotension in Parkinson Disease—A Narrative Review of Diagnosis and Management
Authors: Grosu Cristina , Noea Otilia , Maștaleru Alexandra , Ignat Emilian Bogdan , Leon Maria Magdalena
Published: January 2025

Background: Neurogenic orthostatic hypotension (NOH) is a significant non-motor manifestation of Parkinson’s disease (PD), that substantially affects patient disability and has a powerful impact on the quality of life of PD patients, while also contributing to increased healthcare costs. This narrative review aims to summarize key insights into the diagnosis and management of NOH in individuals with PD. Methods: For diagnosing NOH, a recently introduced and valuable metric is the ΔHr/ΔSBP index. Additional tools, such as autonomic reflex testing and various blood tests, also can be used to help distinguish orthostatic hypotension (OH) from NOH. Results: Treatment strategies for NOH involve both non-pharmacological and pharmacological approaches. As NOH frequently coexists with other abnormal blood pressure patterns (supine hypertension, nocturnal hypertension, and non-dipping hypertension), its treatment can be a challenge for the clinician. Droxidopa and midodrine are the primary pharmacological agents for NOH, though emerging therapies, such as norepinephrine transporter inhibitors, are being investigated. Conclusions: Despite these advancements, further research is needed to better understand the underlying pathophysiology of NOH, enabling more tailored and effective treatment options for individuals with PD.
Plasma Endothelin-1 Levels: Non-Predictors of Alzheimer’s Disease Reveal Age Correlation in African American Women
Authors: Zagol-Ikapitte Irene A. , Tabatabai Mohammad A. , Wilus Derek M. , Alcendor Donald J.
Published: January 2025

Background/Objectives: Alzheimer’s disease (AD) and related dementias (ADRD) disproportionately impact racial and ethnic minorities. Contributing biological factors that explain this disparity have been elusive. Moreover, non-invasive biomarkers for early detection of AD are needed. Endothelin-1 (ET-1), a vasoconstrictive factor linked to cerebral vascular disease pathology and neuronal injury, could provide insights to better understand racial disparities in AD. As a potent vasoconstrictive peptide that regulates contractions in smooth muscle, endothelial cells, and pericytes, ET-1 may result in cerebral vascular constriction, leading to cerebral hypoperfusion; over time, this may result in neuronal injury, contributing to the pathology of AD. The role of the ET-1 system as a driver of ethnic disparities in AD requires further investigation. In the United States (U.S.), ET-1 dysregulation in Hispanic/Latinx (H/L) ethnic populations has largely been unexplored. Genetics linking ET-1 dysregulation and racial disparities in AD also require further investigation. In this study, we examined the role of the ET-1 protein in human plasma as a potential biomarker with predictive value for correlating with the development of AD by age, race, and sex. Methods: We examined ET-1 protein levels using quantitative mass spectrometry in AA and NHW patients with AD, along with controls. Results: A partial correlation between age at draw and ET-1, stratified by race and sex, while controlling for AD status, was significant for female AAs (r = 0.385, p = 0.016). When the data were not stratified but controlled for AD status, the partial correlation between age at draw and ET-1 was not significant (r = 0.108, p = 0.259). Conclusions: Based on the small number of plasma specimens and no plasma specimens from H/L individuals with AD, we conclude that ET-1 was clearly not a significant factor in predicting AD in this study and will require a larger scale study for validation.
Imaging Retrospective Study Regarding the Variability of the Osseous Landmarks for IAN Block
Authors: Urîtu Andrei , Roi Ciprian , Roi Alexandra , Motofelea Alexandru Cătălin , Badea Ioana , Chioran Doina , Riviș Mircea
Published: January 2025

Background/Objectives: The aim of this study is to identify the most accurate and consistent landmarks for determining the precise location of the mandibular foramen (MF) and the mandibular ramus, suggesting appropriate adjustments to anesthesia techniques based on these variations in order to improve the success rate of the inferior alveolar nerve (IAN) block. Methods: CT scans of the mandibles from 100 patients were analyzed to measure the distance between the MF and various landmarks, including the sigmoid notch, gonion, posterior and anterior margins of the ramus, temporal crest, and the mandibular ramus height from the condyle to the gonion. The width of the mandibular ramus was also assessed, with correlations made to age and gender. Results: The MF was found to be closer to the sigmoid notch (mean = 21.2 mm), p = 0.393, than to the gonion (mean = 22.6 mm), p = 0.801, and closer to the posterior margin of the ramus (mean = 13.1 mm), p = 0.753, than to the anterior margin of the ramus. Additionally, the MF was closer to the temporal crest. Age also influenced the position of the MF, with a posterior and superior movement of the foramen, reducing the distance between the MF and the posterior margin of the ramus as well as the MF and the sigmoid notch (p < 0.001). Conclusions: A precise understanding of the MF’s location will help dentists and oral and maxillofacial surgeons improve the success of the IAN block, avoid injury to the inferior alveola neurovascular bundle, and minimize surgical complications such as paresthesia, permanent anesthesia, and hemorrhage.
Predictive Value of the DETECT Algorithm for Pulmonary Arterial Hypertension in Systemic Sclerosis: Findings from an Italian Observational Study
Authors: Stano Stefano , Iannone Claudia , D’Agostino Carlo , Pellico Maria Rosa , Urso Livio , Del Papa Nicoletta , Caporali Roberto , Cacciapaglia Fabio
Published: January 2025

Background/Objectives: Pulmonary arterial hypertension (PAH) is a complication of systemic sclerosis (SSc), and several screening algorithms have been proposed for the early detection of PAH in SSc. This study aimed to evaluate the predicting values of the DETECT algorithm for SSc-PAH screening in patients with SSc undergoing right heart catheterization (RHC) based on 2015 ESC/ERS echocardiographic criteria in a real-life setting. Methods: Patients fulfilling the 2013 ACR/EULAR classification criteria for SSc and with available data for PAH screening with the DETECT algorithm and the 2015 ESC/ERS echocardiographic criteria were retrospectively enrolled from January to June 2017 and then followed for 5 years. Baseline and annual clinical, laboratory, and instrumental data were collected. Results: A total of 33 out of 131 (25%) patients were selected based upon the ESC/ERS echocardiographic criteria, but 30 (23%) underwent RHC, while 51 (39%) patients with SSc were positive based on the DETECT algorithm. PAH diagnosis was confirmed in 28/30 cases (93.3%). The DETECT algorithm showed lower specificity and positive predictive value (PPV) (p < 0.0001) but higher sensitivity and negative predictive value (NPV) (p < 0.0001) than ESC/ERS criteria. Notably, patients with SSc with a negative DETECT screening at baseline had a low probability of developing PAH during a 5-year follow-up (OR 0.15, 95% CI 0.10–0.60—p < 0.0001). Conclusions: The DETECT algorithm has proven to be an easy, fast, and inexpensive tool for screening PAH in patients with SSc. Overall, a low probability of PAH using DETECT is highly predictive of a good prognosis.
Retrospective Analysis of R-COMP Therapy in Patients with Diffuse Large B-Cell Lymphoma (DLBCL): Assessing the Impact of Sample Selection Bias
Authors: Romano Chiara , Branda Francesco , Petrosillo Nicola , Arcari Annalisa , Merli Francesco , Spina Michele , Ceccarelli Giancarlo , Ciccozzi Massimo , Scarpa Fabio , Rigacci Luigi
Published: January 2025

Background: Retrospective studies are often criticized for their susceptibility to case selection bias compared to prospective studies, which include all patients consecutively and are thus less prone to such limitations. However, the larger sample sizes typical of retrospective studies can sometimes offset this drawback. On behalf of the Fondazione Italiana Linfomi (FIL), a substantial retrospective study involving 946 patients was conducted to examine the use of non-pegylated liposomal anthracycline (Myocet). This was followed by a prospective study, the Prospective Elderly Project, which enrolled 308 patients treated with the same liposomal anthracycline regimen. Methods: The objective of this analysis was to determine whether the patient cohort from the retrospective study significantly differed from the cohort in the prospective study. Statistical hypothesis testing was applied to assess whether the samples from both studies originated from the same underlying population. The Anderson–Darling test, a non-parametric statistical method, was utilized to evaluate and compare the overall survival distributions between the two patient cohorts. Results: The statistical tests produced conflicting results, suggesting a potential selection bias in the retrospective study or the possibility that the two groups were from the same population. These discrepancies may have arisen due to the choice of statistical methods or the quality of the data analyzed. Conclusions: This study highlights the challenges of comparing retrospective and prospective cohorts and underscores the importance of selecting appropriate statistical methodologies. The findings provide valuable insights and lay the groundwork for developing innovative approaches to improve such comparisons in future research.
Impact of Earthquakes During COVID-19 Lockdown on the Pediatric Injury Pattern in the Zagreb Urban Area
Authors: Bobovec Dino , Žigman Tomislav , Lovaković Josip , Augustin Goran , Antabak Anko , Dobrić Ivan
Published: January 2025

Background/Objectives: Previous works on the epidemiology of pediatric trauma during the COVID-19 lockdown observed a decrease in pediatric surgical emergency consultations and fracture referrals. None of those works describes a unique situation in which there is the coexistence of another opposing factor, like an earthquake, that influences the number of injured children’s referrals. Therefore, this study aimed to investigate the influence of earthquakes during the COVID-19 lockdown on pediatric injury pattern referrals at a tertiary care hospital in a urban setting. Methods: A retrospective single-center case-control study comprised a time interval at the time of the COVID-19 lockdown, starting with a day when the biggest earthquake happened and finishing at the end of the confinement period in Zagreb, Croatia (22 March–27 April 2020). The control group comprised the identical time interval in 2019. We identified all successive pediatric trauma patients referred to the Pediatric Emergency Department. Demographics and leading injury characteristics were analyzed. Results: We analyzed data from 1166 patients. In the case group, the median age was lower than in the control group but without gender differences. We detected a decrease in Pediatric Emergency Department referrals and a reduced proportion of pediatric trauma patients in the case group. Additionally, the proportion of shoulder/elbow injuries and head injuries was higher, and the proportion of foot/ankle injuries was lower in the case period than in the control period. Conclusions: Earthquakes during the COVID-19 lockdown changed the pattern of pediatric injuries. These data can be used to restructure health resources during similar conditions to provide optimal health care to children.
Joint Analysis of Cardiovascular Control and Shear Wave Elastography to Determine Carotid Plaque Vulnerability
Authors: Bari Vlasta , Cairo Beatrice , Gelpi Francesca , Fancoli Fabiana , Curcio Nicoletta , Matrone Giulia , Righini Paolo , Nano Giovanni , Porta Alberto , Mazzaccaro Daniela
Published: January 2025

Background/Objectives: Carotid artery stenosis (CAS) is one of the main causes of stroke, and the vulnerability of plaque has been proved to be a determinant. A joint analysis of shear wave elastography, a radiofrequency echo-based wall tracking technique for arterial stiffness evaluation, and of autonomic and baroreflex function is proposed to noninvasively, preoperatively assess plaque vulnerability in asymptomatic CAS patients scheduled for carotid endarterectomy. Methods: Elastographic markers of arterial stiffness were derived preoperatively in 78 CAS patients (age: 74.2 + 7.7 years, 27 females). Autonomic and baroreflex markers were also assessed by means of an analysis of the beat-to-beat fluctuations in heart period and systolic arterial pressure, derived at rest in supine position (REST) and during active standing. Postoperative analysis identified 36 patients with vulnerable plaque (VULN) and 42 with stable plaque (STABLE). Results: Baroreflex sensitivity (BRS) at a respiratory rate decreased during STAND only in VULN patients, being much higher at REST compared to STABLE levels. Autonomic indexes were not helpful in separating experimental conditions and/or populations. The Young’s modulus (YM) of the plaque was lower in the VULN group than in the STABLE one. Cardiovascular control and elastographic markers were significantly correlated only in VULN patients. A multivariate logistic regression model built combining YM and BRS at the respiratory rate improved the prediction of plaque vulnerability, reporting an area under the ROC curve of 0.694. Conclusions: Noninvasive techniques assessing shear wave elastography and baroreflex control could contribute to the early detection of plaque vulnerability in patients with asymptomatic CAS.
State of the Art of Primary PCI: Present and Future
Authors: Mignatti Andrea , Echarte-Morales Julio , Sturla Matteo , Latib Azeem
Published: January 2025

Primary percutaneous coronary intervention (PCI) has revolutionized the management of ST-elevation myocardial infarction (STEMI), markedly improving patient outcomes. Despite technological advancements, pharmacological innovations, and refined interventional techniques, STEMI prognosis remains burdened by a persistent incidence of cardiac death and heart failure (HF), with mortality rates plateauing over the last decade. This review examines current practices in primary PCI, focusing on critical factors influencing patient outcomes. Moreover, it explores future developments, emphasizing the role of microvascular dysfunction—a critical but often under-recognized contributor to adverse outcomes, including incident HF and mortality, and has emerged as a key therapeutic frontier. Strategies aimed at preserving microvascular function, mitigating ischemia–reperfusion injury, and reducing infarct size are discussed as potential avenues for improving STEMI management. By addressing these challenges, the field can advance toward more personalized and effective interventions, potentially breaking the current deadlock in mortality rates and improving longer-term prognosis.
Dialysis Patients’ Evaluation of Lung Edema at Home Using a Mobile Phone Tele-Ultrasound Application: A Pilot Study
Authors: Ben Shitrit Itamar , Kedmi Aviya , El Haj Khaled , Kosto Amit , Karni Ofri , Einav Sharon , Poleg Tomer , Hasidim Ariel Avraham , Bineth Noa , Gat Tomer , Shnaider Alla , Barad Orli , Fuchs Lior
Published: January 2025

Background: Home rehabilitation improves patient satisfaction and reduces the need for specialist consultations. Hemodialysis is a costly post-ICU service that requires frequent monitoring. Previous studies have demonstrated the feasibility and accuracy of patients self-scanning their lungs with an ultrasound device within the hospital. Methods: In this single-center, prospective pilot study, we compared the quality of high-risk elderly patient-generated lung ultrasound images against physician-generated images as our primary outcome. The secondary outcome assessed image quality and B-line quantification between a home device and a gold standard device, when operated by the same clinician. Results: We enrolled nine participants (66% male, median age 76 years [IQR 66,79]). Analysis included 402 ultrasound clips (163 patient-generated, 239 physician-generated, and 237 in-clinic gold standard clips). Patient-generated images demonstrated high reliability (92% highly reliable or reliable) and were non-inferior to physician-generated images (p < 0.001). There was substantial agreement in B-line classification (Kw = 0.64, 95% CI: 0.46–0.82). The home device, when operated by the same physician, showed non-inferiority to the gold standard device (p < 0.001) with substantial B-line classification agreement (Kw = 0.64, 95% CI: 0.51–0.78). Conclusions: High-risk elderly patients can successfully generate self-scanned lung ultrasound images comparable to those produced by physicians. These promising results warrant further investigation through larger-scale and long-term studies.
Stability Improvement of Irradiated Polymer Composites by Inorganic Compounds—A Pertinent Solution with Respect to Phenolic Antioxidants
Authors: Zaharescu Traian , Lugāo Ademar B.
Published: January 2025

The long-term usage of polymer products necessitates addressing the appropriate preservation of their low oxidation state that extends the warranty period. The addition of pertinent stabilization components into the composite formulations (synthesis and natural antioxidants, pristine and doped oxides, clays or couples of them) produces an improvement in the kinetic parameters characterizing the accelerated degradation that occurs during high-energy exposures. The competition between the material ageing and the mitigation of oxidation is controlled by the protection efficiency. In this paper, the main advantages of inorganic structures in comparison to classical organic antioxidants are emphasized. A significant improvement in stability, simultaneously associated with the enhancing of functional characteristics, the lack of migration, low cost and easy accessibility, make the reevaluation of certain fillers as stabilizers appropriate. The correlation between the functional properties and the filler nature in polymer materials may be reconsidered for the assessment of the participation capability of inorganic structures in the inhibition of oxidation by the inactivation of free radicals. The lifetimes of degradation intermediates extended by the activities of inorganic compounds are increased by means of electrical interactions involving the unpaired electrons of molecular fragments. These physical contributions are reflected in chemical stability. An essential feature for the presented inorganic options is a strong impact on the recycling technologies of polymers by radiation processing. Plastic products, including all categories of macromolecular materials, can gain an increased durability through the inorganic alternative of protection.
Effects of Microstructured and Anti-Inflammatory-Coated Cochlear Implant Electrodes on Fibrous Tissue Growth and Neuronal Survival
Authors: Fibranz Lennart , Behrends Wiebke , Wulf Katharina , Raggl Stefan , Kötter Lisa , Eickner Thomas , Schilp Soeren , Lenarz Thomas , Paasche Gerrit
Published: January 2025

Cochlear implants are well established devices for treating severe hearing loss. However, due to the trauma caused by the insertion of the electrode and the subsequent formation of connective tissue, their clinical effectiveness varies. The aim of the current study was to achieve a long-term reduction in connective tissue growth and impedance by combining surface patterns on the electrode array with a poly-L-lactide coating containing 20% diclofenac. Three groups of six guinea pigs each (control, structure, structure with diclofenac in the coating) were implanted for four weeks. The hearing thresholds were measured before implantation and after 28 days, and impedances were monitored over time. After histological preparation, connective tissue growth and spiral ganglion neuron (SGN) survival were quantified. The hearing thresholds and impedances increased over time in all groups, showing no significant differences. The treatment groups showed increased damage in the cochlea, which appeared to be caused by the elevated parts of the microstructures. This seems to be amplified by the trauma model used in the current study. The impedances correlated with connective tissue growth near the electrode contacts. In addition, SGN survival was negatively correlated with the presence of connective tissue, both of which highlight the importance of successfully reducing connective tissue formation after cochlear implantation.
Sacrificing Alginate in Decellularized Extracellular Matrix Scaffolds for Implantable Artificial Livers
Authors: Nguyen Chanh-Trung , Le Van Phu , Le Thi Huong , Kim Jeong Sook , Back Sung Hoon , Koo Kyo-in
Published: January 2025

This research introduced a strategy to fabricate sub-millimeter-diameter artificial liver tissue by extruding a combination of a liver decellularized extracellular matrix (dECM), alginate, endothelial cells, and hepatocytes. Vascularization remains a critical challenge in liver tissue engineering, as replicating the liver’s intricate vascular network is essential for sustaining cellular function and viability. Seven scaffold groups were evaluated, incorporating different cell compositions, scaffold materials, and structural configurations. The hepatocyte and endothelial cell scaffold treated with alginate lyase demonstrated the highest diffusion rate, along with enhanced albumin secretion (2.8 µg/mL) and urea synthesis (220 µg/mL) during the same period by day 10. A dense and interconnected endothelial cell network was observed as early as day 4 in the lyased coculture group. Furthermore, three-week implantation studies in rats showed a stable integration to the host with no adverse effects. This approach offers significant potential for advancing functional liver tissue replacements, combining accelerated diffusion, enhanced albumin secretion, improved urea synthesis, dense vascular network formation, and stable implantation outcomes.
Design and Development of a Bespoke Rotary Friction Welding Machine in Exploration of Joining Dissimilar Materials for Nuclear Applications
Authors: Dellepiane Michail , Da Silva Laurie , Toumpis Athanasios
Published: January 2025

Rotary friction welding is a solid-state welding process that can manufacture high-integrity joints between similar and dissimilar materials with short weld times. However, access to expensive and complex industrial-grade friction welding machines is not always possible. This study explores the design process and functionality of a laboratory-scale friction welding setup following the fundamentals of large-scale machinery. The proposed setup is designed to be easily manufactured, employing the use of a calibrated drill press and load cell, thus ensuring welding parameters such as rotational speed and applied axial load are monitored. The decision to investigate rotary friction welding of aluminium bronze Ca104 to austenitic stainless steel AISI316 was taken to explore the limitations of this bespoke friction welding machine for prospective applications in the nuclear energy sector. The workpieces were friction welded at four sets of rotational speeds with constant friction and forging pressures. The microstructural evolution and mechanical properties of the dissimilar material welds were investigated via optical and scanning electron microscopy with energy dispersive spectroscopy, 4-point bend testing and microhardness measurements. Results show a change in the hardness along the weld interface and evidence of metallic diffusion between the dissimilar materials, demonstrating the successful application of the small-scale experimental setup.
Side-Scan Sonar Small Objects Detection Based on Improved YOLOv11
Authors: Zou Chang , Yu Siquan , Yu Yankai , Gu Haitao , Xu Xinlin
Published: January 2025

Underwater object detection using side-scan sonar (SSS) remains a significant challenge in marine exploration, especially for small objects. Conventional methods for small object detection face various obstacles, such as difficulties in feature extraction and the considerable impact of noise on detection accuracy. To address these issues, this study proposes an improved YOLOv11 network named YOLOv11-SDC. Specifically, a new Sparse Feature (SF) module is proposed, replacing the Spatial Pyramid Pooling Fast (SPPF) module from the original YOLOv11 architecture to enhance object feature selection. Furthermore, the proposed YOLOv11-SDC integrates a Dilated Reparam Block (DRB) with a C3k2 module to broaden the model’s receptive field. A Content-Guided Attention Fusion (CGAF) module is also incorporated prior to the detection module to assign appropriate weights to various feature maps, thereby emphasizing the relevant object information. Experimental results clearly demonstrate the superiority of YOLOv11-SDC over several iterations of YOLO versions in detection performance. The proposed method was validated through extensive real-world experiments, yielding a precision of 0.934, recall of 0.698, mAP@0.5 of 0.825, and mAP@0.5:0.95 of 0.598. In conclusion, the improved YOLOv11-SDC offers a promising solution for detecting small objects in SSS images, showing substantial potential for marine applications.
Late Glacial and Holocene Paleoenvironmental Reconstruction of the Submerged Karst Basin Pirovac Bay on the Eastern Adriatic Coast
Authors: Ilijanić Nikolina , Brunović Dea , Miko Slobodan , Hajek Tadesse Valentina , Hasan Ozren , Razum Ivan , Šparica Miko Martina , Mesić Saša
Published: January 2025

This study focuses on the analysis of sediment core retrieved from the deepest part (25 m) of Pirovac Bay. A long sedimentary sequence (7.45 m) supplemented by a shorter sediment core (1.45 m) from a shallower part of the bay was analyzed for sedimentological, mineralogical, geochemical, and micropaleontological (ostracod) parameters. The sediment thickness above the underlying karst paleorelief (karstic bedrock) is up to 12 m. Sediments recorded a transition from a freshwater to a marine environment starting from post-Neapolitan Yellow Tuff tephra sedimentation. First, the floodplain developed in Pirovac Bay, with intermittent pools and ponds, followed by wetland environment. The formation of a shallow freshwater paleolake during the Middle Holocene at 10 cal kyr BP was enabled by the rising sea level and high freshwater input from the karstified underground from the adjacent Lake Vrana (Biograd na Moru). The onset of marine intrusions through the karstified underground is evident with formation of a brackish lake in the Pirovac Bay basin. Marine transgression and flooding of the bay occurred at 7.3 cal kyr BP, evidenced by the geochemical and ostracod parameters, providing crucial insights into the dynamics of coastal inundation under past climate change. Intriguingly, freshwater ostracod species were still present in the marine sediments, brought into the bay from Lake Vrana through surficial canal Prosika and groundwater discharge (numerous estavelles) along the northeastern shores of the bay, proving their mutual influence. This submerged Holocene freshwater paleolake, reported here for the first time, underlines the sensitivity of coastal karst systems to the rise in sea level and serves to stress how important understanding of these processes is for effective management in coastal zone and climate change adaptation strategies. The findings provided evidence supporting the existence of coastal marine basins as freshwater lakes prior to being flooded by seawater as a consequence of the Holocene post-glacial sea level rise.
New Insights into Chemical Profiles and Health-Promoting Effects of Edible Mushroom Dictyophora indusiata (Vent ex. Pers.) Fischer: A Review
Authors: Kumar Yogesh , Xu Baojun
Published: January 2025

Mushrooms are valued for their culinary and medicinal benefits, containing bioactive compounds like polysaccharides, terpenoids, phenolics, lectins, and ergosterols. This review aims to encourage research on D. indusiata by summarizing its chemistry, health benefits, pharmacology, and potential therapeutic applications. Molecules from D. indusiata offer anti-diabetic, antioxidant, anti-tumor, hepatoprotective, and anti-bacterial effects. In particular, polysaccharides from Dictyophora indusiata (DIP) enhance immune function, reduce oxidative stress, and promote gut health as prebiotics. DIP shows neuroprotective effects by reducing oxidative damage, improving mitochondrial function, and regulating apoptosis, making them beneficial for neurodegenerative diseases. They also activate immune responses through TLR4 and NF-κB pathways. Additionally, compounds like dictyophorines and quinazoline from D. indusiata support nerve growth and protection. Mushrooms help regulate metabolism and improve lipid profiles, with potential applications in managing metabolic disorders, cancer, cardiovascular diseases, diabetes, and neurodegenerative conditions. Their wide range of bioactive compounds makes D. indusiata mushrooms functional foods with significant therapeutic potential.
Groundbreaking Technologies and the Biocontrol of Fungal Vascular Plant Pathogens
Authors: Gómez-Lama Cabanás Carmen , Mercado-Blanco Jesús
Published: January 2025

This review delves into innovative technologies to improve the control of vascular fungal plant pathogens. It also briefly summarizes traditional biocontrol approaches to manage them, addressing their limitations and emphasizing the need to develop more sustainable and precise solutions. Powerful tools such as next-generation sequencing, meta-omics, and microbiome engineering allow for the targeted manipulation of microbial communities to enhance pathogen suppression. Microbiome-based approaches include the design of synthetic microbial consortia and the transplant of entire or customized soil/plant microbiomes, potentially offering more resilient and adaptable biocontrol strategies. Nanotechnology has also advanced significantly, providing methods for the targeted delivery of biological control agents (BCAs) or compounds derived from them through different nanoparticles (NPs), including bacteriogenic, mycogenic, phytogenic, phycogenic, and debris-derived ones acting as carriers. The use of biodegradable polymeric and non-polymeric eco-friendly NPs, which enable the controlled release of antifungal agents while minimizing environmental impact, is also explored. Furthermore, artificial intelligence and machine learning can revolutionize crop protection through early disease detection, the prediction of disease outbreaks, and precision in BCA treatments. Other technologies such as genome editing, RNA interference (RNAi), and functional peptides can enhance BCA efficacy against pathogenic fungi. Altogether, these technologies provide a comprehensive framework for sustainable and precise management of fungal vascular diseases, redefining pathogen biocontrol in modern agriculture.
Cross-Border Communication Strategies: An Approach to Spanish Euroregions on Twitter (X)
Authors: Rivas-de-Roca Rubén , Domínguez-García Ricardo , Pérez-Curiel Concha
Published: January 2025

In a political climate of social polarization and distrust in public institutions, which in turn fosters misinformation, the European Union (EU) faces the challenge of becoming closer to its citizens. At the same time, the EU has well-established collaboration mechanisms at the local and regional levels. In this context, this study aims to analyze the Euroregions project, one of the strategies used by the EU to manage the different regions of Europe through cross-border collaboration. Thus, the main objective of this study is to find out, using the social network X (formerly Twitter), the communication strategies deployed by the regional governments that make up each of the five Spanish Euroregions on institutions of cross-border cooperation. The results show that regional governments do not promote effective communication strategies to publicize these Euroregions. Rather, these governments try to communicate their management success, focusing their discourse on the issue of European funds and thus generating a situation of misinformation around the benefits of belonging to the European Union. Our findings contribute to the budding literature on regional European areas, arguing that certain political actions could ameliorate the feeling of disaffection of the population towards European institutions.
Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling: In Vivo and In Silico Studies
Authors: Abdou Heba M. , Elmageed Ghada M. Abd , Hussein Hussein K. , Yamari Imane , Chtita Samir , El-Samad Lamia M. , Hassan Mohamed A.
Published: January 2025

Type 2 diabetes mellitus (T2DM) is an intricate disease correlated with many metabolic deregulations, including disordered glucose metabolism, oxidative stress, inflammation, and cellular apoptosis due to hepatic gluconeogenesis aberrations. However, there is no radical therapy to inhibit hepatic gluconeogenesis disturbances yet. We thus sought to probe the effectiveness and uncover the potential mechanism of quercetin (QCT) and silk sericin (SS) in mitigating hyperglycemia-induced hepatic gluconeogenesis disorder, which remains obscure. Administration of QCT and SS to diabetic male albino rats markedly restored the levels of glucose, insulin, advanced glycation end-products (AGEs), liver function enzymes, alpha-fetoprotein (AFP), globulin, and glycogen, in addition to hepatic carbohydrate metabolizing enzymes and gluconeogenesis in comparison with diabetic rats. Furthermore, treatment with QCT and SS modulated hepatic malondialdehyde (MD), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), nitric oxide, tumor necrosis factor-alpha (TNF-α), and interleukin-1β (IL-1β), in addition to serum interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2), implying their effectiveness in safeguarding cells against oxidative impairment and inflammation. Remarkably, QCT and SS treatments led to the upregulation of expression of phosphatidylinositol 3-kinases (PI3K), phospho-Akt (p-Akt), and forkhead box-O1 (FOXO1) genes in hepatic tissues compared to diabetic rats, orchestrating these singling pathways for curtailing hyperglycemia and pernicious consequences in hepatic tissues. Importantly, immunohistochemical investigations exhibited downregulation of caspase-3 expression in rats treated with QCT and SS compared to diabetic animals. Beyond that, the histopathological results of hepatic tissues demonstrated notable correlations with biochemical findings. Interestingly, the in silico results supported the in vivo findings, showing notable binding affinities of QCT and SS to PI3K, GPx, and TNF-α proteins. These results imply that QCT and SS could mitigate oxidative stress and inflammation and regulate hepatic gluconeogenesis in diabetic rats. However, QCT revealed greater molecular interactions with the studied proteins than SS. Overall, our results emphasize that QCT and SS have significant therapeutic effects on attenuating hyperglycemia-induced hepatic gluconeogenesis, with QCT showing superior effectiveness.
Cybersecurity in Digital Accounting Systems: Challenges and Solutions in the Arab Gulf Region
Authors: Morshed Amer , Khrais Laith T.
Published: January 2025

The region of the Arab Gulf is marching ahead very fast toward digitalization in ways prompted by initiatives, such as Saudi Vision 2030 and the UAE’s strategy for Smart Government. Thus, both underscore the boundless movement toward the inclusion of advanced technologies into accounting practices, such as Business Intelligence and Enterprise Resource Planning systems. While these technologies enhance efficiency and facilitate informed decision-making, they also render financial data vulnerable to cybersecurity threats, such as phishing, ransomware, and insider attacks. This paper investigates the impact of cybersecurity practices, ethical accountability, regulatory frameworks, and emerging technologies on the adoption of and trust in digital accounting systems in the GCC region. A quantitative research approach was followed, wherein the responses from a randomly selected sample of 324 professionals representing the GCC nations were collected. The empirical analysis was completed using Partial Least Squares Structural Equation Modeling. Strong cybersecurity measures, AI-driven threat detection mechanisms, and custom-fit employee training programs facilitate the adoption of and faith in digital accounting information systems considerably. Ethical accountability acts as the partial mediator of those effects, and supportive regulatory frameworks enhance cybersecurity strategy effectiveness. This study examines the development of integrated cybersecurity strategies with respect to technology, ethics, and regulations. It makes several major recommendations, calling for bringing the GCC countries’ regulatory frameworks into line with international standards; encouraging workforce training programs; and utilizing AI-powered technologies for proactive threat detection and management. These findings can arm stakeholders with a holistic pathway toward developing secure, resilient, and future-oriented digital accounting infrastructures across the region.
“Nice to Meet You in Masks”: How Virtual Avatars Enhance User Experience on Random Video Chat Platforms
Authors: Gu Chao , Sun Xin , Wei Wei , Sun Jie , Zeng Yingjie , Zhang Lie
Published: January 2025

This study aims to understand how interaction design can enhance the user experience of random video chats using virtual avatars (RVC–VAs). We propose a framework to explain the mechanisms underlying changes in social anxiety and flow experiences. We applied analysis of variance (ANOVA), structural equation modeling (SEM), and fuzzy set qualitative comparative analysis (fsQCA) to data collected through surveys. Our findings indicate that a second-order construct, named mysterious interaction, comprising perceived interactivity, perceived vividness, and mystery, can reduce social anxiety and positively impact flow. Novelty experience enhances flow for female users but increases social anxiety for all users. Notably, social anxiety unexpectedly showed a positive effect on flow. Based on these findings, we propose interaction design strategies that could aid in the development and optimization of RVC-VA platforms, providing specific parameters to assist designers in prioritizing and planning actionable steps. This study makes a significant contribution to the advancing of online social services and addressing users’ needs for online social interaction.
Tourism Development of Cultural Heritage Resources Through Conservation Concepts: A Case Study of Ningxia, China
Authors: Zhang Shengrui , Hu Tianyi , Zhang Tongyan , Ju Hongrun , Wang Yingjie
Published: January 2025

Cultural heritage resources represent a vital aspect of tourism in the Ningxia Hui Autonomous Region, an area characterized by its ethnic minority heritage. This study innovatively proposes a classification framework for cultural heritage based on the principles of protection and the demands of tourism development. For the first time, it combines kernel density analysis and spatial autocorrelation methods to conduct a quantitative study on the geographical distribution of cultural heritage in Ningxia, covering aspects such as scale, structure, distribution characteristics, and influencing factors. The findings reveal: (1) Religious and Ceremonial Sites: Ningxia boasts the highest number of religious and ceremonial sites, totaling 1741. (2) Geographical Distribution: Resources are distributed in a multicore pattern, concentrated in Longde and Zhongning Counties, while the central and western areas are less rich. (3) Regional Concentration: The eastern region shows a high concentration of resources, contrasting with the low concentration in the north. (4) Influencing Factors: Social factors like GDP per capita, urbanization, and population density significantly affect this spatial pattern, although natural factors like altitude are also important. Consequently, the paper recommends increased government investment in cultural heritage tourism; enhanced integration of heritage tourism between urban core areas and countryside zones; increased investment in the protection and development of cultural heritage in high-altitude and remote areas. These findings aim to promote the sustainable growth of Ningxia’s cultural heritage and offer insights for similar regions.
Ecological Management Zoning Identification by Coupling Blue-Green and Gray Infrastructure Networks: A Case Study of Guizhou Province, China
Authors: Song Shuang , Zhang Xuanhe , Wang Shaohan , Gong Yue
Published: January 2025

Ecological management zoning is crucial for maintaining regional ecological security and realizing differentiated urban ecological governance. However, the existing zoning methods are overly focused on ecological functional attributes and fail to adequately consider the impacts of human activities, resulting in an insufficiently rational allocation of resources. Taking Guizhou Province as an example, using multi-source data and spatial analysis tools, this study proposed an ecological management zoning framework based on the coupling analysis of the blue-green infrastructure (BGI) network and gray infrastructure (GI) network. The results indicated that (1) the BGI network in the study area included 179 sources, with a total area of 54,228.80 km2, and 232 corridors. (2) There were 53 sources in the GI network, totaling 709.19 km2, and the corridors of the first, second, and third levels were 11,469.31 km, 6703.54 km, and 5341.30 km, respectively. (3) There were 606 barrier points identified, mainly distributed in the central part of the study area, and the total area of the disturbance zone was 1132.50 km2, which had the largest distribution in Qiandongnan, followed by Qiannan. (4) At the county scale, five ecological management zones were identified in the study area based on four indicators, namely, the source area ratio of BGI network, corridor density of BGI network disturbance zone area ratio, and density of barrier point. Then, we proposed targeted optimizations and restorations for each zone. This study organically linked ecological functional attributes and anthropogenic impacts to identify ecological management zones, which will provide new perspectives on synergies between ecological protection and economic development.
Analysis of Parcel Delivery Issues at ‘State Parcel Company’: An Examination of Customer Complaints and Interrelationships
Authors: Čižiūnienė Kristina , Šiugždinytė Augustė , Matijošius Jonas
Published: January 2025

Background: The research presented here looks into ongoing problems with the package delivery services of a State parcel company, especially concerning damaged, wrongly delivered, late, and missing packages. These problems greatly affect customer satisfaction, so it is important to understand how they are connected. Methods: Three hundred and seventy-five customer complaints made between 2021 and 2023 were analyzed. Paniotto’s method was used to ensure that the study data accurately represented the situation. Pearson’s correlation coefficients helped find statistical links between different delivery problems. Results: The analysis revealed significant linkages among the core delivery issues. A strong positive correlation was found between damaged shipments and misdelivered shipments (r = 0.93835) and between prolonged delivery delays and lost goods (r = 0.9188). These findings suggest that addressing one issue may reduce the prevalence of others, given their tendency to coexist. Conclusions: The study emphasizes the necessity for the State parcel firm to execute a comprehensive strategy to improve the overall quality of parcel delivery services. Addressing concerns such as poor delivery and delays is critical since they are closely related to package damage and loss, which affects customer satisfaction.