bluuebunny/crossref_metadata_2025 huggingface dataset:
What will your verse be? Un emblema contemporáneo / What will your verse be? A Contemporany Emblem
Authors: Zafra Molina Rafael
Published: January 2024

ABSTRACT: This article aims to show how the emblematic technique initiated by Andrea Alciato in the 16th century is still valid in some way in current advertising. To this end, I first analyze in depth an example –emblem 153, Cum larvis non luctandum– of how the Milanese author manages, through the combination of an Erasmian adage, a Hellenistic epigram and a related image, to revitalize the topical message contained within them. The article continues on to show how a very similar method is used in the Your Verse campaign by the creative minds of the TBWA\Media Arts Lab and Apple to evoke all the prestige and evocative capacity contained in the film Dead Poets Society and its protagonist Robin Williams, on his already iconic iPad.
KEYWORDSEmblem Theory; Alciato; Apple Inc.; TBWA\Media Arts Lab; Advertising; Commonplaces.
RESUMEN: Este artículo pretende mostrar como la técnica emblemática iniciada por Andrea Alciato en el siglo XVI sigue vigente de algún modo en la publicidad actual. Para ello primero se analiza en profundidad un ejemplo –el emblema 153, Cum larvis non luctandum– de cómo el autor milanés consigue, mediante la combinación de un adagio de Erasmo, un epigrama helenístico y una imagen relacionada, revitalizar el mensaje tópico encerrado en ellos. A continuación, se muestra cómo un método muy similar es empleado en la campaña Your verse por los creativos de TBWA\Media Arts Lab y Apple para atraer todo el prestigio y capacidad de evocación encerrados en la película El club de los poetas muertos y su protagonista Robin Williams sobre su ya icónico iPad.
Humildad y purificación: continuidad y variación del tipo iconográfico del lavatorio de pies / Humility and Purification: Continuity and Variation of the Iconographic Type of Foot Washing
Authors: Bernad López Victoria
Published: January 2024

ABSTRACT: Christ’s washing of the feet of the apostles is one of the iconographic types that make up the theme of The Last Supper. This event is first narrated in the Gospel of John, who relates it in detail, something that the synoptic Gospels do not do. The main objective of this article is to carry out a diachronic study of the continuity and variation of this typology. This essay provides research on this iconographic type from its origin and development in the East and further development in the West after the fall of Constantinople. To achieve this goal, I have utilized the iconographic-iconological method, paying close attention to the relationship between the written and visual sources. Studying these biblical and patristic texts allows us to reflect on the significance of washing understood as a process of purification, of the forgiveness of sins, and as a gesture of humility on the part of Christ. Finally, I deal with some aspects relating to the context related to the conceptual and imaginary scope of the iconographic type. I deal mainly with issues relating to the Councils and Synods that established the sacraments related to penance and confession, as well as those that formed the basis of the practice of washing within the liturgy.
KEYWORDSLavatory; Modesty; Purification; Penance; Confession.
RESUMEN: Uno de los tipos iconográficos que forman parte del tema de la Última Cena es el del lavatorio de pies de Cristo a los apóstoles, pasaje narrado únicamente en el Evangelio de Juan quien lo desarrolla de forma detallada a diferencia de los evangelios sinópticos. El objetivo principal de este artículo reside en realizar un estudio diacrónico de la continuidad y variación de esta tipología desde su nacimiento en Oriente y su posterior desarrollo en Occidente tras la caída de Constantinopla. Para alcanzar dicho objetivo, se ha utilizado el método iconográfico-iconológico atendiendo a la relación de las fuentes con las imágenes. El estudio de estos textos bíblicos y patrísticos, ha permitido realizar una reflexión acerca de la significación del lavatorio entendido como un proceso de purificación, de perdón de los pecados y como gesto de humildad por parte de Cristo. Finalmente, se han abordado algunos aspectos relativos al contexto donde se ha puesto en relación el tipo con su ámbito conceptual e imaginario tratando cuestiones relativas a los concilios y sínodos donde quedaron fijados los sacramentos relativos a la penitencia y confesión, así como aquellos  donde se asientan las bases de la práctica del lavatorio dentro de la liturgia.
Ingeniosa Assiduitate
Authors: Editorial Equipo
Published: January 2024

Ingeniosa Assiduitate
WHOSE SUPPER IS IT? HAMLET AND WORMS AS ACTANTS IN THE ELSINORE (AND NOT ONLY) GASTRONOMY
Authors: Sosnowska Monika
Published: January 2024

Adopting a posthumanist perspective, and by peering through an ecocritical lens, I look for connections, interactions, relationships and even inter-species dependencies to be found Shakespeare’s Hamlet, where apart from the ghost, even a worm finds shelter. Hamlet himself delves into various issues in the Elsinore space / land / gastronomy, and among others… worms. While investigating the “unnatural” death of his own father, he considers many natural phenomena, including the circulation of matter, where the role of worms is crucial. And making the connection, I reflect on present-day funeral practices and think about future human burial places and their forms. I also make an attempt to show that, although in culture worms do not mean much, for ecosystems they are important beings (recyclers and fertilizers), having a real impact on their condition and balance. Drawing on contemporary scientific findings, I identify the worms mentioned by Hamlet, indicating specific invertebrate organisms. I also propose a new term for non-human Others–the BioDiverse.
BILDER AUS DER SPRACHE? EKPHRASIS, GEDÄCHTNIS UND DAS PROBLEM DER SPRACHLICHEN BILDER IN EINEM GEDICHTBAND VON IMRE ORAVECZ
Authors: PATAKI VICTOR
Published: January 2024

The dilemma of comparing picture and lyrical language can be perfectly parallelized with the unique (generical or media related) process of ekphrasis. This process also highlights the cohesive being of mediums from an iconological, and also from a poetological point of view. The interpretation of ekphrasis could accessed from the contradiction of memorising techniques and genres. Hence apart from the examination of ekphrasis and poems, the dichotomies of prose and poem, prosepoem and longpoem, as well as narration and lyricism are also part of the study. Several descriptive poems of Imre Oravecz are, in fact, ekphrasises, which can visualise and prove the accessibility of language and pictures.
WĘGIERSKIE FILMY FABULARNE OPOWIADAJĄCE O PROBLEMATYCE REWOLUCJI LAT 1848–49, STRATEGIE I GATUNKI
Authors: BUBAK GRZEGORZ
Published: January 2024

This article explores Hungarian feature films about the Uprising of 1848-1849, the author reviews the productions on this issue in terms of the presented threads, film genres, and ways of showing the events of the mid-19thcentury. Focusing on the visual material, one can see that the creators analyzed and presented the Spring of Nations in various ways. Some of them treated history as a starting point for their faithful historical stories, for others the revolution was just a pretext to tell their stories. Oft en the plots of the films take place many years aft er the revolution, and the characters refer to it only in their memories. Over the years, the message underwent metamorphosis, initially the revolution appeared only as a romantic, heroic uprising. Later, the events took on the characteristics of a terrible drama and recently they have acquired a less dramatic tone.
CON TINTA Y PLUMA EN EL BURDEL: CORTESANAS EN LE SEI GIORNATE DE PIETRO ARETINO
Authors: DOMINICCI-BUZÓ JOSÉ
Published: January 2024

The work Le sei giornate by Pietro of Arezzo (1492-1556) is notable for its intricate, ambiguous, and challenging nature, particularly in relation to its exploration of sexuality. , which involves the explicit depiction of bodies as carnal and forbidden, representing a deviation from conventional norms. Le sei giornate (also known as Ragionamenti; or, Dialogue of Nanna and Antonia under a Fig Tree in Rome) exalts licentiousness from the unique perspective of a woman who embodies the roles of nun, wife, and courtesan. This article examines the portrayal of the courtesan in Aretino’s text, tracing the influences—from Pasquin to Rabelais—that propelled this relatively underappreciated author into the realm of the notoriety. Through an exploration of its connection with the public square and its association with the carnivalesque, this study delves into the historical backdrop of 16th-century Italy.
Spatial chromatin accessibility sequencing resolves high-order spatial interactions of epigenomic markers
Authors: Xie Yeming , Ruan Fengying , Li Yaning , Luo Meng , Zhang Chen , Chen Zhichao , Xie Zhe , Weng Zhe , Chen Weitian , Chen Wenfang , Fang Yitong , Sun Yuxin , Guo Mei , Wang Juan , Xu Shouping , Wang Hongqi , Tang Chong
Published: January 2024

As the genome is organized into a three-dimensional structure in intracellular space, epigenomic information also has a complex spatial arrangement. However, most epigenetic studies describe locations of methylation marks, chromatin accessibility regions, and histone modifications in the horizontal dimension. Proper spatial epigenomic information has rarely been obtained. In this study, we designed spatial chromatin accessibility sequencing (SCA-seq) to resolve the genome conformation by capturing the epigenetic information in single-molecular resolution while simultaneously resolving the genome conformation. Using SCA-seq, we are able to examine the spatial interaction of chromatin accessibility (e.g. enhancer–promoter contacts), CpG island methylation, and spatial insulating functions of the CCCTC-binding factor. We demonstrate that SCA-seq paves the way to explore the mechanism of epigenetic interactions and extends our knowledge in 3D packaging of DNA in the nucleus.
Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice
Authors: Chen Jinjing , Wang Ruoyu , Xiong Feng , Sun Hao , Kemper Byron , Li Wenbo , Kemper Jongsook
Published: January 2024

The nuclear receptor, farnesoid X receptor (FXR/NR1H4), is increasingly recognized as a promising drug target for metabolic diseases, including nonalcoholic steatohepatitis (NASH). Protein-coding genes regulated by FXR are well known, but whether FXR also acts through regulation of long non-coding RNAs (lncRNAs), which vastly outnumber protein-coding genes, remains unknown. Utilizing RNA-seq and global run-on sequencing (GRO-seq) analyses in mouse liver, we found that FXR activation affects the expression of many RNA transcripts from chromatin regions bearing enhancer features. Among these we discovered a previously unannotated liver-enriched enhancer-derived lncRNA (eRNA), termed FXR-induced non-coding RNA (Fincor). We show that Fincor is specifically induced by the hammerhead-type FXR agonists, including GW4064 and tropifexor. CRISPR/Cas9-mediated liver-specific knockdown of Fincor in dietary NASH mice reduced the beneficial effects of tropifexor, an FXR agonist currently in clinical trials for NASH and primary biliary cholangitis (PBC), indicating that amelioration of liver fibrosis and inflammation in NASH treatment by tropifexor is mediated in part by Fincor. Overall, our findings highlight that pharmacological activation of FXR by hammerhead-type agonists induces a novel eRNA, Fincor, contributing to the amelioration of NASH in mice. Fincor may represent a new drug target for addressing metabolic disorders, including NASH.
Illuminating T cell-dendritic cell interactions in vivo by FlAsHing antigens
Authors: Akkaya Munir , Al Souz Jafar , Williams Daniel , Kamdar Rahul , Kamenyeva Olena , Kabat Juraj , Shevach Ethan , Akkaya Billur
Published: January 2024

Delineating the complex network of interactions between antigen-specific T cells and antigen presenting cells (APCs) is crucial for effective precision therapies against cancer, chronic infections, and autoimmunity. However, the existing arsenal for examining antigen-specific T cell interactions is restricted to a select few antigen-T cell receptor pairs, with limited in situ utility. This lack of versatility is largely due to the disruptive effects of reagents on the immune synapse, which hinder real-time monitoring of antigen-specific interactions. To address this limitation, we have developed a novel and versatile immune monitoring strategy by adding a short cysteine-rich tag to antigenic peptides that emits fluorescence upon binding to thiol-reactive biarsenical hairpin compounds. Our findings demonstrate the specificity and durability of the novel antigen-targeting probes during dynamic immune monitoring in vitro and in vivo. This strategy opens new avenues for biological validation of T-cell receptors with newly identified epitopes by revealing the behavior of previously unrecognized antigen-receptor pairs, expanding our understanding of T cell responses.
A wave of minor de novo DNA methylation initiates in mouse 8-cell embryos and co-regulates imprinted X- chromosome inactivation with H3K27me3
Authors: Yue Yuan , Fu Wei , Yang Qianying , Zhang Chao , Wang Wenjuan , Chu Meiqiang , Lyu Qingji , Tang Yawen , Cui Jian , Wang Xiaodong , Zhang Zhenni , Tian Jianhui , An Lei
Published: January 2024

DNA methylation is extensively reprogrammed during early stage of mammalian development and is essential for normal embryogenesis. It is well established that mouse embryos acquire genome-wide DNA methylation during implantation, referred to as
de novo
DNA methylation, from globally hypomethylated blastocysts. However, the fact that the main
de novo
DNA methyltransferase 3B (DNMT3B) is initially expressed as early as the 8-cell stage, contradicts the current knowledge about timing of initiation of
de novo
DNA methylation. Here, we reported that a previously overlooked minor wave of
de novo
DNA methylation initially occurs during the transition from the 8-cell to blastocyst stage, before the well-known large-scale
de novo
DNA methylation during implantation. Functional analyses indicated that minor
de novo
DNA methylation regulates proliferation, lineage differentiation and metabolic homeostasis of preimplantation embryos, and is critical for embryonic developmental potential and pregnancy outcomes. Furthermore, bioinformatic and functional analyses indicated that minor
de novo
DNA methylation preferentially occurs on the X chromosome and co-regulates imprinted X-chromosome inactivation via the interaction between DNMT3B and polycomb repressive complexes 2 core components during blastocyst formation. Thus, our study updates the current knowledge of embryonic
de novo
DNA methylation, thereby providing a novel insight of early embryonic epigenetic reprogramming.
Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity
Authors: He Jitian , Gao Le , Wang Peiying , Chan Wing Keung , Zheng Yiran , Zhang Yumo , Sun Jiaman , Li Xue , Wang Jiming , Li Xiao-Hong , Chen Huaiyong , Yang Zhouxin , Wang Youwei
Published: January 2024

Group 1 innate lymphoid cells (ILCs) comprise conventional natural killer (cNK) cells and type 1 innate lymphoid cells (ILC1s). The main functions of liver cNK cells and ILC1s not only include directly killing target cells but also regulating local immune microenvironment of the liver through the secretion of cytokines. Uncovering the intricate mechanisms by which transcriptional factors regulate and influence the functions of liver cNK cells and ILC1s, particularly within the context of liver tumors, presents a significant opportunity to amplify the effectiveness of immunotherapies against liver malignancies. Using Ncr1-drived conditional knockout mouse model, our study reveals the regulatory role of Prdm1 in shaping the composition and maturation of cNK cells. Although Prdm1 did not affect the killing function of cNK cells in an in vivo cytotoxicity model, a significant increase in cancer metastasis was observed in Prdm1 knockout mice. Interferon-gamma (IFN-γ), granzyme B, and perforin secretion decreased significantly in Prdm1-deficient cNK cells and liver ILC1s. Single-cell RNA sequencing (scRNA-seq) data also provided evidences that Prdm1 maintains functional subsets of cNK cells and liver ILC1s and facilitates communications between cNK cells, liver ILC1s, and macrophages. The present study unveiled a novel regulatory mechanism of Prdm1 in cNK cells and liver ILC1s, showing promising potential for developing innovative immune therapy strategies against liver cancer.
Reorganization of the flagellum scaffolding induces a sperm standstill during fertilization
Authors: Jabloñski Martina , Luque Guillermina M , Gomez Elias Matias , Sanchez Cardenas Claudia , Xu Xinran , de La Vega Beltran Jose L , Corkidi Gabriel , Linares Alejandro , Abonza Victor , Arenas-Hernandez Aquetzalli , Ramos-Godinez María DP , López-Saavedra Alejandro , Krapf Dario , Krapf Diego , Darszon Alberto , Guerrero Adán , Buffone Mariano G
Published: January 2024

Mammalian sperm delve into the female reproductive tract to fertilize the female gamete. The available information about how sperm regulate their motility during the final journey to the fertilization site is extremely limited. In this work, we investigated the structural and functional changes in the sperm flagellum after acrosomal exocytosis (AE) and during the interaction with the eggs. The evidence demonstrates that the double helix actin network surrounding the mitochondrial sheath of the midpiece undergoes structural changes prior to the motility cessation. This structural modification is accompanied by a decrease in diameter of the midpiece and is driven by intracellular calcium changes that occur concomitant with a reorganization of the actin helicoidal cortex. Midpiece contraction occurs in a subset of cells that undergo AE, and live-cell imaging during in vitro fertilization showed that the midpiece contraction is required for motility cessation after fusion is initiated. These findings provide the first evidence of the F-actin network’s role in regulating sperm motility, adapting its function to meet specific cellular requirements during fertilization, and highlighting the broader significance of understanding sperm motility.
Global vision object detection using an improved Gaussian Mixture model based on contour
Authors: Sun Lei
Published: January 2024

Object detection plays an important role in the field of computer vision. The purpose of object detection is to identify the objects of interest in the image and determine their categories and positions. Object detection has many important applications in various fields. This article addresses the problems of unclear foreground contour in moving object detection and excessive noise points in the global vision, proposing an improved Gaussian mixture model for feature fusion. First, the RGB image was converted into the HSV space, and a mixed Gaussian background model was established. Next, the object area was obtained through background subtraction, residual interference in the foreground was removed using the median filtering method, and morphological processing was performed. Then, an improved Canny algorithm using an automatic threshold from the Otsu method was used to extract the overall object contour. Finally, feature fusion of edge contours and the foreground area was performed to obtain the final object contour. The experimental results show that this method improves the accuracy of the object contour and reduces noise in the object.
DoAP2/ERF89 activated the terpene synthase gene DoPAES in Dendrobium officinale and participated in the synthesis of β-patchoulene
Authors: Li Decong , Liu Lin , Li Xiaohong , Wei Guo , Cai Yongping , Sun Xu , Fan Honghong
Published: January 2024

Dendrobium officinale Kimura et Migo is a tonic plant that has both ornamental and medicinal properties. Terpenoids are significant and diverse secondary metabolites in plants, and are one of the important natural active ingredients in D. officinale. The AP2/ERF gene family plays a major role in primary and secondary metabolism. However, the AP2/ERF transcription factor family has not been identified in D. officinale, and it is unclear if it is involved in the regulation of terpenoid biosynthesis. This study identified a sesquiterpene synthetase-β-patchoulene synthase (DoPAES) using transcriptome and terpenic metabolic profile analyses. A total of 111 members of the AP2/ERF family were identified through the whole genome of D. officinale. The tissue-specific expression and gene co-expression pattern of the DoAP2/ERF family members were analyzed. The results showed that the expression of DoPAES was highly correlated with the expression of DoAP2/ERF89 and DoAP2/ERF47. The yeast one-hybrid (Y1H) assays and dual-luciferase experiments demonstrated that DoAP2/ERF89 and DoAP2/ERF47 could regulate the expression of DoPAES. The transcriptional regulatory effects were examined using homologous transient expression of DoAP2/ERF89 in protocorms of D. officinale. DoAP2/ERF89 positively regulated the biosynthesis of β-patchoulene. This study showed that DoAP2/ERF89 can bind to the promoter region of DoPAES to control its expression and further regulate the biosynthesis of β-patchoulene in D. officinale. These results provide new insights on the regulation of terpenoid biosynthesis.
Efectos de la autoidentificación feminista en la estrategia de femvertising en México
Authors: Martínez-Aguirre Atziri , Cavazos-Arroyo Judith , Carrillo-Durán María Victoria , Castillo-Villar Fernando Rey
Published: January 2024

En los últimos años, la publicidad que comunica empoderamiento de la mujer y pretende eliminar los estereotipos de género (femvertising) ha cobrado importancia para varias empresas como forma de acercarse y conectar con el público femenino. Este estudio tiene dos objetivos; primero, analizar el efecto de la autoidentificación feminista sobre la confianza y la congruencia de la femvertising de una marca y, segundo, analizar el efecto de la confianza y la congruencia de la femvertising en la actitud hacia la femvertising y el efecto de esta sobre la intención de compra de la marca. Se desarrolló una investigación cuantitativa, explicativa y transversal en 401 mujeres pertenecientes a la generación centennial, consumidoras de una marca de agua embotellada que realiza femvertising como parte de su comunicación publicitaria. Mediante un análisis con ecuaciones estructuales, los resultados evidencian que la autoidentificación feminista impacta negativamente sobre la confianza y la congruencia percibida de la femvertising de la marca. Sin embargo, la confianza y la congruencia percibida de la marca influyen positivamente en la actitud hacia la femvertising, la cual muestra un efecto positivo hacia la intención de compra. Es necesario profundizar la investigación en la femvertising para desarrollar estrategias de comunicación más eficientes hacia esta audiencia.
Análise de viabilidade entre alvenaria estrutural cerâmica e a construção convencional
Authors: Pascoalino Jefferson Soares , Marotta Luiza Ignez Mollica , Santos Gustavo Soares , Clemente Guilherme Augusto Bertelli Fernandes , Lima Gilberto de Miranda , Cunha Fabiano Martins
Published: January 2024

Dentre os fatores mais importantes na construção de uma edificação estão o custo e a qualidade do material empregado. Diante disso é possível inovar e demonstrar novas opções ao cliente. Um método construtivo muito utilizado no Brasil, principalmente em municípios localizados no estado de São Paulo é o método chamado de alvenaria estrutural cerâmica. Este método possui diversas vantagens em relação ao método de construção convencional, que serão abordadas neste artigo. Este artigo possui por objetivo analisar e comparar os métodos construtivos de alvenaria estrutural cerâmica com o método de construção convencional. Para isso, foi efetuado um comparativo dos custos e viabilidade dos materiais e, em sequência foi obtido qual dos dois métodos possui maior custo benefício. A comparação dos custos foi feita através da confecção de um projeto de um sobrado de 317,16m², onde foi efetuado o levantamento do quantitativo de materiais e, posteriormente dos custos. Para o levantamento dos custos e posteriormente a comparação destes. Concluíu-se que a alvenaria estrutural teve uma redução de cerca de 20% no custo final em comparação ao  método de construção convencional.
Ethical, legal, and information management aspects in the context of patient safety
Authors: Tino Cláudio Fernandes , Becker Ana Cláudia , Pereira Bianca , Corrêa Larissa da Rosa , Soares Marison Luiz , Nascimento-e-Silva Daniel
Published: January 2024

Health systems around the world currently generate diverse health data related to their patients; their potential for use in the routine of health professionals is recognized; however, at the same time, patient safety is also widely discussed since, over the years, the patient's electronic medical record absorbs sensitive information, accumulated over time. In this sense, this study aimed to address ethical, legal, and information management aspects in the context of patient safety. This is a scoping review, conducted based on the methodological structure developed by the Joanna Briggs Institute and the checklist Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews, set in five stages: 1) identification of the research question, 2) bibliographic survey to search for relevant studies, 3) selection of studies, according to the criteria defined in this review, 4) data mapping and 5) presentation of results. The results showed that a) the articles, in general, pay much attention to patient safety, both in terms of data and also in terms of health; b) International patient safety goals were created to standardize care in private and public hospitals, c) The articles address patient safety by international patient safety goals and d) information leakage is becoming increasingly common, and actions are needed to minimize these situations. The conclusion shows that there is a lack of objective studies regarding the use of information technology in patient safety and that, due to the importance of these topics, both in public health and economic issues, more studies are necessary for an effective implementation that can generate practical results to patients and the country's healthcare system.
Avaliação de projetos em feiras científicas estudantis combinando value-focused thinking e analytic hierarchy process
Authors: Françozo Rafael Verão , Carrapateira Elana Souza , Da Silva Amanda Cecília Simões , Belderrain Mischel Carmen Neyra , Ramos Vilma dos Santos , Dos Santos Jean Jackson Martinez , Leite Afonso Henrique da Silva
Published: January 2024

Feiras estudantis são bastante populares e um dos principais eventos realizados no Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso do Sul (IFMS) durante a Semana Nacional de Ciência e Tecnologia. Um desafio em tais eventos consiste no julgamento e classificação dos projetos expostos. Este estudo tem por objetivo apresentar um modelo de avaliação dos projetos das feiras estudantis no âmbito do IFMS considerando aspectos subjetivos no julgamento dos avaliadores. Para este propósito foi adotada uma abordagem envolvendo Value-Focused Thinking (VFT) para identificação dos objetivos e critérios e Analytic Hierarchy Process (AHP) para avaliação. Os resultados indicam julgamentos mais consistentes considerando a subjetividade dos avaliadores com relação aos critérios. A abordagem proposta envolvendo VFT e AHP contribuiu com a definição dos critérios a serem avaliados assim como o grau de importância de cada critério para a avaliação geral dos projetos.
Turmeric; The Cutting Edge of India’s Merchandise and Global Medicine
Authors: Mishra Durga Prasad , Mishra Siba Prasad , Mishra Saswat , Pattnaik Sanjeeb
Published: January 2024

Turmeric has served as a potential chemotherapeutic and chemo-preventive drug in Asia for about four to five thousand years of human civilization. It occupies a significant place in religious rituals, kitchens as food additives, and many ethno-phyto-pharmaceutical safe drugs in Asia and worldwide. India is the top producer (about 80%), and a leading exporter of turmeric, rich in containing curcumin and turmerone oil in the world. The demand for turmeric and its marketing strategy of turmeric has reached its peak as a naturopathic drug of choice during the SARS-02 pandemic from 2020 onwards. The Indian yellow saffron grows as an organic spice to augment the economic, societal, and environmental conditions of tribal in hilly areas in India adding to the value chain.

The existing study envisages the evaluation of the levels of all chemical constituents including heavy/radioactive metals present in turmeric, so that the widely used turmeric may have some refinement to enhance food safety and its standards. MITUTOYO microscope and X-ray fluorescence Spectrometer (XRF) were used for both yellow and black varieties of turmeric specimens from various places like Kandhamal, Koraput, and Khordha districts to examine and compare the chemical contents.

Turmeric, the both black and yellow variety is the rhizome of the Zingiberaceae (ginger) family, mostly grown by using the organic methodology in hilly terrains of India. Iron and few metals and rare earth metals are present in small proportions but zinc which is the potential immune developer in the human body is almost absent in turmeric. The volatile oil, colouring materials, culinary flavoured spices, or common cosmetics extracted from turmeric. They have wide applications in Ayurveda including cardio-protective, Anti-septic, blood level depressant, anti-cancer, antioxidant, antifertility, antidepressant, anti-allergic, anti-inflammatory, neuro/ nephron-protective, immune-modulatory, anti-microbial, and anti-cancer, etc. Despite well-proven drug of choice in naturopathy and Ayurveda, turmeric is not a widely accepted ingredient in pharmacy, the modern allopathic drug structure, which needs attention.
Path Coefficient Analysis of Rice (Oriza sativa L.) Genotype under Laboratory Conditions
Authors: Kumar Sunil , Vimal S. C. , Singh Jay , Gupta Rishabh , Yaduvanshi Niharika , Singh Yogendra Pratap
Published: January 2024

The present investigation was conducted at Seed Testing Laboratory of Seed Technology Section, Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya (U.P.). The study was based on the germplasm evaluation of 45 germplasm including three checks viz., NDR-2065, BPT 5204 and Sambha sub1. Seedling length (0.366), speed of germination (0.132), Seed width (0.108), shoot length (0.082), seed weight (0.064), root length (0.061), vigour index-II (0.057) and L/B ratio (0.033) existed substantial positive effects on vigour index-I. Seeds weight (0.875), followed by seed width (0.610), exerted very high order positive indirect effects on vigour index-I seed weight substantial positive indirect effects on seed vigour index-I via seed width were also contributed by seed width (0.610), seedling length (0.552),  L/B ratio (0.294), seedling dry weight (0.037) made considerable positive indirect on vigour index-I. The lowest and highest mean performance for root length (cm) was noted for B-4311 (10.50 cm) and HRT-m-20/3220 (31.20 cm) respectively. None of the 45 lines were statically inferior or superior than general mean for root length which 14.63 cm. out of 45 genotypes, nineteen were statistically at par with the best genotype is HRT-m-20/3220.
Prevalence of One Humped Camel Mange and Its Associated Risk Factors in Selected Kebeles of Kebri-Beyah District of Fafan Zone, Somali Regional State, Ethiopia
Authors: Ahmed Mustafe Abdi , Ibrahim Abdillahi Saleban , Bashir Bashir Mohamed , Mahamed Samatar Abshir
Published: January 2024

Camel mange is an extremely pruritic and contagious disease of camel caused by a small parasite Sarcoptes scabiei var cameli, It mostly affects the head, neck, flanks, inner side of the thighs and inguinal region of the animal. It is transmitted by direct or indirect contact, is one of the most important parasitic diseases affecting camels. Camel mange is economically important disease that hinders productivity and health of camel. Therefore, a cross sectional study was conducted between March to September 2021 to determine prevalence of camel mange mites and associated risk factors. A total of 384 animals were randomly selected and subjected to skin scrapings to recover mange from suspected lesions which was later on examined under microscope, out of the complete camels examined 116 (30.2%) camels were found positive for mange mite infestation. Only Sarcoptes scabiei var cameli was identified as the only mite species in all skin scraping samples collected from the suspected mange mite lesions. Peasant association, sex and age showed no significant variation on mange infestation (P>0.05), while only body condition and herd size were shown statistically significant difference in prevalence of mange mites (P<0.05). This study indicates that camel populations in Kebribeyah district had large amount of mange mites which could hamper health and production status of the camels. Therefore, more emphasis should be given to improve the management system, further studies and control measures should be conducted to shrink the effect of mange mite infestation on camel husbandry.
Electronic doors to education: study of high school website accessibility in Iowa
Authors: Klein David , Myhill William , Hansen Linda , Asby Gary , Michaelson Susan , Blanck Peter
Published: February 2003

The Americans with Disabilities Act (ADA), and Sections 504 and 508 of the Rehabilitation Act, prohibit discrimination against people with disabilities in all aspects of daily life, including education, work, and access to places of public accommodations. Increasingly, these antidiscrimination laws are used by persons with disabilities to ensure equal access to e‐commerce, and to private and public Internet websites. To help assess the impact of the anti‐discrimination mandate for educational communities, this study examined 157 website home pages of Iowa public high schools (52% of high schools in Iowa) in terms of their electronic accessibility for persons with disabilities. We predicted that accessibility problems would limit students and others in obtaining information from the web pages as well as limiting ability to navigate to other web pages. Findings show that although many web pages examined included information in accessible formats, none of the home pages met World Wide Web Consortium (W3C) standards for accessibility. The most frequent accessibility problem was lack of alternative text (ALT tags) for graphics. Technical sophistication built into pages was found to reduce accessibility. Implications are discussed for schools and educational institutions, and for laws, policies, and procedures on website accessibility. Copyright © 2003 John Wiley & Sons, Ltd.
Technology for independence: a community‐based resource center
Authors: Blanck Peter , Ritchie Heather , Schmeling James , Klein David
Published: February 2003

Despite the prominence of the disability civil rights model—with its values of inclusion and empowerment—the majority of social and policy research conducted to date has not sufficiently included the perspective of persons with disabilities in the research process and as uniquely qualified researchers themselves. This article describes a new project, “Technology for Independence: A Community‐Based Resource Center” (CBRC). Over a five‐year period, the CBRC will attempt to enhance community and consumer‐directed disability organizations to design, implement, and disseminate research that promotes access to and use of assistive technology (AT). The CBRC will use strategies such as leadership training, participatory action research, technical assistance, web‐ assisted training, and annual symposia. A primary goal of the CBRC is to increase the capacity of community organizations to conduct research on AT that is scientifically rigorous and relevant to disability services, policy, and law. Copyright © 2003 John Wiley & Sons, Ltd.
Morphological characteristics of total joint arthroplasty‐derived ultra‐high molecular weight polyethylene (UHMWPE) wear debris that provoke inflammation in a murine model of inflammation
Authors: Sieving Allison , Wu Bin , Mayton Lois , Nasser Sam , Wooley Paul H.
Published: February 2003

It is recognized that the chronic inflammation in peri‐prosthetic tissue that contributes to implant failure frequently is provoked by the presence of wear debris. Some wear debris is inevitable because of the nature of the prosthesis, but not all patients develop severe inflammatory responses. The precise factors that mediate the severity of tissue inflammation to wear debris has yet to be fully defined. Because wear debris retrieved from peri‐prosthetic tissue consists of a heterogeneous mixture of materials with various sizes and shapes, this study evaluated the influence of two major physical aspects of ultra‐high molecular weight polyethylene (UHMWPE) wear debris (shape and surface texture) using a model of tissue inflammation. UHMWPE debris particulates recovered from 50 peri‐prosthetic tissue samples were examined by scanning electron microscopy and categorized into four groups based upon aspect ratio and surface texture of the material. The four groups were defined as: 1) smooth and globular, 2) smooth and fibular, 3) rough and globular, and 4) rough and fibular. Histological analysis and ELISA assays were conducted to evaluate variations in cellular responses and cytokine production between the groups. The strongest expression of tumor necrosis factor alpha and interleukin‐1 beta was found in tissues exposed to UHMWPE debris with both a rough surface texture and fibular shape, and this response was significantly elevated over debris particles with a smooth surface texture and globular shape. The data suggest that both shape and texture influence the severity of specific inflammatory responses and that rough debris surface texture exerts a marked effect on adverse tissue responses when combined with particles that have a sharp, elongated shape. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 64A: 457–464, 2003
Modification of calcium–phosphate coatings on titanium by recombinant amelogenin
Authors: Wen H. B. , Moradian‐Oldak J.
Published: February 2003

Amelogenin proteins, the principal components of the developing dental enamel extracellular matrix, have been postulated to facilitate the elongated and oriented growth of the carbonated apatite crystals during enamel formation. We previously reported that amelogenin caused modulation of apatite crystals nucleated on a bioactive glass (Bioglass®) in vitro. Here, the effects of amelogenin on the growth morphology of calcium–phosphate crystals nucleated on a titanium surface were investigated in order to gain a better understanding of the role of amelogenins during enamel biomineralization and to explore their potential application in the design and development of novel biomaterials. The dose‐dependent effects of a recombinant mouse amelogenin (rM179) were found to be different from those of bovine serum albumin, which significantly inhibited apatite crystal growth and caused the octacalcium phosphate (OCP) crystals to change from a plate‐like shape to a curved shape, indicating a general inhibitory effect. The effects of rM179 on the crystal growth of OCP at 12.5–100 μg/mL and of apatite at 50 μg/mL were insignificant while the apatite crystals were remarkably elongated along their c‐axes upon the use of 100 μg/mL of rM179. The unique modulation of the calcium–phosphate coatings on titanium by rM179 supports the view that amelogenins have a great potential for applications designed to develop novel biomimetic materials. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 64A: 483–490, 2003
Clinical presentations in combat veterans diagnosed with posttraumatic stress disorder
Authors: Elhai Jon D. , Frueh B. Christopher , Davis Joanne L. , Jacobs Gerard A. , Hamner Mark B.
Published: February 2003

This article investigated subtypes of symptom patterns among male combat veterans diagnosed with posttraumatic stress disorder (PTSD) through a cluster analysis of their Minnesota Multiphasic Personality Inventory‐2 (MMPI‐2; Butcher, Graham, Ben‐Porath, Tellegen, Dahlstrom, & Kaemmer, 2001) clinical and validity scales. Participants were 126 veterans seeking
outpatient treatment for combat‐related PTSD at a Veterans Affairs Medical Center. Two well‐fitting MMPI‐2 cluster solutions (a four‐cluster solution and a three‐cluster solution) were evaluated with several statistical methods. A four‐cluster solution was determined to best fit the data. Follow‐up analyses demonstrated between‐cluster differences on MMPI‐2 “fake bad” scales and content scales, the Beck Depression Inventory (BDI; Beck, Ward, Mendelson, Mock, & Erbaugh, 1961), Dissociative Experiences Scale (DES; Bernstein & Putnam, 1986), Mississippi Combat PTSD scale (M‐PTSD; Keane, Caddall, & Taylor, 1988), and Clinician‐Administered PTSD Scale (CAPS‐1; Blake et al., 1990). Clusters also were different in disability‐seeking status, employment status, and income. Implications for research and clinical practice using the MMPI‐2 with combat veterans presenting with PTSD are briefly addressed. © 2003 Wiley Periodicals, Inc. J Clin Psychol 59: 385–397, 2003.
Measuring health‐related quality of life in women with urogenital dysfunction: The urogenital distress inventory and incontinence impact questionnaire revisited
Authors: van der Vaart C. Huub , de Leeuw J. Rob J. , Roovers Jan‐Paul W.R. , Heintz A. Peter M.
Published: February 2003

Aims

Symptoms of urogenital dysfunction are known to negatively affect health‐related quality of life in women. To assess effectiveness of treatment, it is currently recommended to include measurements of quality of life in outcome analysis. One of the questionnaires that is commonly used is the combination of the Urogenital Distress Inventory (UDI) and Incontinence Impact Questionnaire (IIQ). Unfortunately, the validity of the UDI and IIQ has only been tested in highly selected subgroups of female patients. Therefore, it is unclear whether this questionnaire is suitable for use in populations with different characteristics.

Methods

We analyzed the scale construction and validity of the UDI and IIQ in a random sample of 2,042 women, aged 20–70 years old and a clinical sample of 196 women.

Results

Our results show that the UDI can be divided into five subscales, namely discomfort/pain, urinary incontinence, overactive bladder, genital prolapse, and obstructive micturition. The internal consistency (Cronbach's alpha) ranged between 0.74 and 0.82. In addition to the original four subscales of the IIQ (mobility, physical, social, and emotional functioning), we identified a fifth subscale with four items about embarrassment. Internal consistency of these subscales ranged between 0.83 and 0.93. In addition to the internal consistency, we tested the criterion and construct validity of these new subscale division.

Conclusions

We found these subscales to be reliable and of clinical use. It is recommended to use the revised UDI and IIQ in outcome analysis of treatments for urogenital symptoms in women. Neurourol. Urodynam. 22:97–104, 2003. © 2003 Wiley‐Liss, Inc.
Effects of ATP‐sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction
Authors: Fey Thomas A. , Gopalakrishnan Murali , Strake James G. , King Linda L. , Brioni Jorge D. , Sullivan James P. , Coghlan Michael J. , Brune Michael E.
Published: February 2003

Aims

To compare in vivo the efficacy, potency, and bladder–vascular selectivity of ATP‐sensitive potassium channel openers (KCOs), YM934 and (‐)‐cromakalim to a muscarinic antagonist, tolterodine in a novel partial outlet obstructed pig model.

Methods

Partially obstructed female Landrace pigs were implanted with telemetry transmitters to allow the continuous measurement of intravesical, abdominal and arterial pressures. A subcutaneous port catheter was used to adjust bladder volume. Bladder and arterial pressure were simultaneously monitored under isoflurane anesthesia before and after increasing i.v. doses of test compounds.

Results

Under anesthesia, voiding was completely inhibited, but spontaneous, nonvoiding bladder contractions were observed with mean amplitude of 16 ± 1 cm H2O, duration of 35 ± 2 seconds, and intercontraction interval of 43 ± 4 seconds (n = 25). YM934 and (‐)‐cromakalim both caused dose‐dependent decreases in bladder contraction area under the curve (AUC) with effective doses to inhibit AUC by 35% of 3.6 and 14.9 nmol/kg, i.v., respectively. However, concomitant reductions in mean arterial pressure of 12 and 13% were also observed. Tolterodine did not inhibit spontaneous bladder contractions at doses up to 100 nmol/kg, i.v. corresponding to plasma concentrations up to 41 ng/mL.

Conclusions

The superior efficacy of KCOs to inhibit spontaneous bladder contractions relative to tolterodine support the hypothesis that KCOs may provide an alternate therapeutic mechanism to treat symptoms of overactive bladder if bladder‐vascular selectivity can be sufficiently improved. The minimally invasive model described herein appears useful in the preclinical evaluation of potential therapeutics targeted to treat the overactive bladder. Neurourol. Urodynam. 22:147–155, 2003. © 2003 Wiley‐Liss, Inc.
Determination of the molecular relationship between multiple tumour nodules in hepatocellular carcinoma differentiates multicentric origin from intrahepatic metastasis
Authors: Ng Irene Oi‐lin , Guan Xin‐yuan , Poon Ronnie Tung‐ping , Fan Sheung‐tat , Lee Joyce Man‐fong
Published: February 2003

The purpose of this study was to determine the molecular relationship between multiple tumour nodules in hepatocellular carcinoma (HCC) within individual patients and to evaluate their clonality, which may bear prognostic significance. In 25 HCC nodules from 11 patients with multiple HCCs, the clonal relationships of the nodules within individual patients were determined using DNA fingerprinting with loss of heterozygosity (LOH) assay, comparative genomic hybridization (CGH), and hepatitis B virus (HBV) integration pattern. Both LOH assay and CGH indicated that in four (36%) of the 11 patients, the multiple HCCs had different clonalities and hence were of multicentric origin, whereas in the remaining seven (64%) patients, the multiple HCCs had similar clonal relationships and were intrahepatic metastases. In selected cases, the HBV integration pattern helped to confirm the clonality results. Gross appearance, size, location, and histology of the tumours could not accurately predict their clonal origin in every case. Assessment of DNA alterations allows precise determination of the clonality of multiple HCCs within one patient. Of these molecular methods, LOH analysis can be used to evaluate tumour clonality in most patients even before surgical resection, since this assay can be readily applied routinely to either liver biopsies or fine needle aspirates. Copyright © 2003 John Wiley & Sons, Ltd.