bluuebunny/crossref_metadata_2025 huggingface dataset:
Should Peer Review be confidential?
Authors: Fenner Martin
Published: October 2021

Donald Kennedy, the edior-in-chief of Science, yesterday wrote an editorial about a legal dispute between the New England Journal of Medicine and the drug company Pfizer. Pfizer wants the NEJM to provide the reviewer comments on submitted papers about the two Pfizer products celecoxib (Celebrex) and valdecoxib (Bextra). Both drugs are used to treat pain and belong to the COX-2 inhibitor class of drugs.
Public Access Week: Who could read my papers?
Authors: Fenner Martin
Published: October 2021

I did a little experiment to figure out whether the full-text versions of my last 15 papers (published between 1997-2008) are available online. The result:3 papers available for everybody10 papers only available from within my institution (Journal subscription required)2 papers only available for purchase Interestingly, the papers in the two journals with the highest impact factor are both available as full-text.
Public Access Week: Personal Summary
Authors: Fenner Martin
Published: October 2021

The new NIH Public Access policy started this past Monday. Fellow Nature Networker Graham Steel has summarized this week's reaction of the blogosphere. I would like to highlight some of the discussions we had here on Nature Network. Bob O'Hara wonders about the cost of publishing in Open Access: Show us the Money!. He argues that shifting the costs from reader to author can create problems.
On Guest authors and Ghostwriters
Authors: Fenner Martin
Published: October 2021

The legal disputes following the withdrawal from the market of two drugs for the treatment of pain (the COX-2 inhibitors rofecoxib and valdecoxib) have led to another critical examination of the paper publishing process. I have written in February about the drug company Pfizer trying to obtain confidential peer review documents from the journals JAMA and NEJM. Courts in Chicago and Boston have denied such requests.
Considering posting your paper in a repository? Think again
Authors: Fenner Martin
Published: October 2021

Our recent discussion on public access made me have a closer look on the options I have for my own papers. The results aren't pretty.Most journals allow posting post-prints on a university website The copyright agreement with the journal is the easy part. Most publishers allow posting of post-prints (after peer-review, but not the journal PDF) in a non-commercial repository, usually the repository of your institution.
Web 2.0 for Scientists: Where are the Applications?
Authors: Fenner Martin
Published: October 2021

The success or failure of Web 2.0 efforts for scientists depends to a large extend on the availability of cool applications that make the everyday life of a scientist easier. Many of these applications of course already exist, but I would argue that there is a lot of room for improvement.
Why local hubs in Nature Network are important
Authors: Fenner Martin
Published: October 2021

Earlier this week Matt Brown announced important changes to the Nature Network software: The first step towards new local hubs. Most importantly, it is now possible to set your location and hub. The hub can be the same as the location, or a city or region nearby (as in my case Berlin). Later this year, Nature Network will add new hubs to the existing London and Boston.
We need markup for science blogs
Authors: Fenner Martin
Published: October 2021

Like many other blogging platforms, Nature Network uses Textile to format blog entries. Textile is a markup language, and Andrew Sun has nicely put together the most important tags in this blog post. Unfortunately, Textile doesn't much help with formatting that is specific to science blogging. Specifically, there is no standard way to link to journal articles.
Book Review: Bad Science by Ben Goldacre
Authors: Fenner Martin
Published: October 2021

Ben Goldacre: Bad Science. Published September 2008 by Fourth Estate Ltd. Paperback, 352 pages, ISBN 0007240198

Ben Goldacre, blogger of the

Bad Science

[1] column in the Guardian newspaper, in September published a book based on material from his blog. Just like the newspaper column, the book is primarily intended for a general audience rather than the trained scientist or medical doctor.
How readers can support the Front Matter blog
Authors: Fenner Martin
Published: October 2021

The Front Matter blog launched last week and while the content is currently only written by me, I hope this will change in the coming months to include one-time guest posts and regular writers. One challenge is to figure out how to finance the blog in the long run.
Apoyo y Responsabilidad Medioambiental en la Comunidad de Quinrapa en el Distrito de Huanta, Perú
Authors: Manrique-Cóndor Maricela , Rico-Taguada Ana Fiorela , Cardenas-Quispe Mariano Anthony , Tello-Tello Segundo Víctor
Published: October 2021

La autoridad Nacional del Agua (ANA) es el ente encargado de gestionar sosteniblemente y multisectorial el recurso del agua. Por lo cual se busca determinar el grado el apoyo y responsabilidad medioambiental de la Autoridad Nacional del Agua (ANA) en el Distrito de Huanta, comunidad de Quinrapa. La investigación tuvo enfoque cualitativo de tipo descriptivo y diseño no experimental a nivel correlacional causal de corte transversal. La muestra estuvo conformada por 18 integrantes del comité de regantes Quinrapa, siendo el muestreo no probabilístico intencional, habiéndose excluido a los miembros de comunidades aledañas; La técnica utilizada fue la encuesta y los instrumentos utilizados fueron cuestionarios. Los resultados mostraron que el 94.4% a recibido apoyo de las autoridades, pero solo el 50% conoce sobre la gestión del ANA, En conclusión, se demostró que el Distrito de Huanta, comunidad de Quinrapa tiene apoyo de las autoridades, sin embargo, existe un desconocimiento parcial sobre la responsabilidad y gestión de la Autoridad Nacional del Agua en la zona.
DİJİTAL PARA VE EGEMENLİK
Authors: ÇATLI Mehmet , ŞİMŞEK Sümeyye
Published: October 2021

Bu çalışmada dijital para birimlerinin egemenlikle olan ilişkisi ele alınmıştır. Paranın egemenlik ile doğrudan bir ilişkisi vardır. Para, egemenliğin sembolü olarak kabul edilmektedir. Egemenliğini göstermek isteyen hükümdarlar kendi adlarına para bastırmışlardır. Devletin kendi ulusal parası, onun egemenliğini simgelemektedir. Egemenlik kavramı para basma yetkisini de bünyesinde barındırır. Egemen devletler para basma tekelini elinde bulundururlar. Her devlet, kendi para birimi üzerinde tekele sahiptir, fakat devletin para üzerindeki egemenliği zamanla aşındırılmak istenmiştir. Bu amaçla ulus üstü kurum ve kuruluşlar oluşturulmuştur ve paranın kurallarını bunlar belirlemeye başlamışlardır. Küreselleşmenin etkisiyle teknoloji geliştikçe ulus devletlerin para üzerindeki egemenliğini aşındıracak başka bir şey daha ortaya çıkmıştır: dijital para. Literatürde dijital para kavramı yerine sanal para, kripto para gibi farklı kavramlar kullanılabilmektedir. Çalışmada ifade edilen dijital para birimleri ise merkez bankası tarafından çıkarılmamaktadır. Arkasında devlet gücü bulunmamaktadır. Dijital para birimleri devletsiz ve denetimsizdir. Devlet tarafından değil de özel kişiler tarafından çıkarılmaktadır. Bunlar devlet tarafından kontrol edilememektedir. Devlet tekeline meydan okumaktadır ve egemenliği tehdit etmektedir. Egemen, bu tehdit karşısında sessiz kalmamaktadır.
GAİPLİĞİN MİRAS HUKUKU BAKIMINDAN DEĞERLENDİRİLMESİ
Authors: ASLAN BİNGÖL Kemale Leyla
Published: October 2021

Türk Medeni Kanunu’nun (TMK) 28. madde hükmü uyarınca, “kişilik, çocuğun sağ olarak tamamıyla doğduğu anda başlar ve ölümle sona erer”. Yine TMK uyarınca kişilik; “ölüm” (m. 28/I) ve “gaiplik” (m. 32/I) olmak üzere iki şekilde sona erebilir. Kişiliğin sona ermesi ile, kişiye bağlı haklar son bulmakta, diğer haklar ise mirasçılara geçmektedir. Kişiden uzun süreden beri haber alınamaması veya kişinin ölüm tehlikesi içerisinde kaybolması durumlarında kanunumuz, “gaiplik” kavramından bahsetmektedir. Kişi hakkında gaiplik kararı verilmesi durumunda, ölüm halinde olduğu gibi kişilik sona ermektedir. Gaiplik, kişinin ölümüne kesin gözle bakılmayı gerektiren bir durum söz konusu olmasa da ölmüş olabileceğine dair ciddi şüphelerin bulunması halinde ortaya çıkmaktadır. Gaiplik belli koşullara ve mahkemenin vereceği gaiplik kararına tabi kılınmıştır. Çalışmamızda gaiplik kararının koşullarına, hâkimin gaiplik kararı vermesine ve bu kararın miras hukukundaki yansımalarına yer verilmiştir. Miras hukuku bakımından konu esasen iki boyutta; hem gaiplik kararı verilen kişinin mirası, hem de mirasçıların gaip olması bakımından ayrı ayrı incelenmiştir. Ayrıca çalışmada, Hazine’nin gaiplik kararı alma koşulları da değerlendirilmiştir. Hazine’nin bu talebini hangi koşullarda ileri sürebileceği ve sonuçları hakkında bilgi verilmiştir.
Investigating Coercion, Abuse, and Manipulation: Recognizing the Legacy of the Cold War
Authors: Woody William , Payne Jill , LaFary Kathryn , Gretz David , Roseblum Charles
Published: October 2021

In this manuscript, the authors examine the Cold War roots of the movement to study groups that engage in undue influence. In particular, the authors consider the transitions of some scholars directly from Cold War brainwashing research to the study of these groups and also the activities of researchers who did not directly address groups but established enduring foundations in this field. The authors also consider expert testimony in both the Hearst trial and a government program, the Survival, Evasion, Resistance, and Escape training program, which brought together disparate scholars to address these ideas. The authors then examine the influence of developments in social psychology on approaches to Cold War brainwashing and its connection to the later literature about groups that may use undue influence. The paper concludes with a review of strengths and limitations from this literature that remain in the study of these groups.
Evaluation of the Performance of Cryogenically Treated Carbide İnserts in the Turning of AISI 1040 Steel
Authors:   Department of Machine and Manufacturing, Isparta University of Applied Sciences, Isparta, Turkey, Calik Adnan
Published: October 2021

-In this study, the effects of cryogenic treatment on tool wear and surface roughness of tungsten carbide inserts coated with TiAlN were investigated as a function of cutting speed and feed rate. It is observed that the surface roughness increases with increased cutting speed, feed rate and also applied cryogenic processing. In other words, the effect of feed rate and cutting speed is very high on the surface roughness. On the other hand, the results showed that the cryogenic treatment is a non-effective process to enhance the wear resistance and tool life of inserts due to brittle region between coated layer and surface
On the Question of Electro mobility Promotion
Authors:   National Academy of Sciences of Belarus, 66, Independence av., Minsk, 220072, Belarus, Yankevich Natallia , Yankevich Stsiapan
Published: October 2021

To create a competitive and resource-efficient transport system, the European Union transport policy provides by 2030 achieving almost zero carbon dioxide emissions of vehicles used in large urban centers, and gradually phasing out the use of vehicles using traditional fuels - by 2050. The large-scale and accelerated development of the principles of electric mobility in Europe can make a significant contribution to the realization of these goals, has a positive impact on the ecological friendliness of the environment, and can also improve the situation with employment in Europe. However, it is impossible to abandon immediately of piston power units, including diesel ones - there are too many of them. Moreover, considering the size of the ―carbon footprint‖ of cars, which means the totality of all the harmful emissions and greenhouse gases that an object produces during its life cycle, it is currently impossible to state unambiguously about the environmental superiority of electric vehicles compared to cars equipped with gasoline and diesel engines. Therefore, the development of approaches that can justify strategic directions, describing the principles of long-term operation of machines with various types of engines, is relevant
On Development Strategies for Improving the Management Level of Chinese Enterprises in Africa: the case of Chinese enterprises in Kenyan
Authors: Wang Jiaxiu
Published: October 2021

China has become Africa’s largest trading partner. The level of economic and trade cooperation between China and Kenya have been continuously improved within the framework of the China-Africa Community of Shared Future and the “Belt and Road” cooperation. Nowadays, the cooperation between China and Kenya is standing at a new starting point and facing new development opportunities. Chinese enterprises in Kenya have developed rapidly in terms of number and scale in recent years. And the businesses involve a wide range of fields, ranging from agricultural and sideline products and food industry to precision parts processing and manufacturing, which have created a considerable number of jobs for the local area and increased the overall labor income. However, there are still many outstanding problems in specific cooperation practices, such as the lack of attention on corporate management and corporate culture. Based on literature analysis, this article uses Chinese enterprises in Kenya as an example to illustrate the development status of Chinese companies in Africa, study the problems that exist in the development of Chinese companies in Kenya and propose solutions to the corresponding problems. The further development of Chinese enterprises in Africa will promote the better realization of the China-Africa community with a shared future and the development of the “Belt and Road” to achieve a win-win situation.
A análise linguística intercultural em eventos de formação de professoras de Português como Língua de Acolhimento
Authors: Azambuja Flávia , Dornelles Clara , Costa Everton Vargas da
Published: October 2021

O objetivo deste trabalho é investigar como a prática de análise linguística acontece na perspectiva intercultural em eventos de formação de professoras de Português como Língua de Acolhimento (PLAc). Para isso, nos ancoramos no conceito de eventos de formação (COSTA, 2013; 2018; LEMOS, 2014), de análise linguística (MENDONÇA, 2006; 2007a e b) e de interculturalidade (JANZEN, 2005; TORQUATO, 2014; 2016). A pesquisa centra-se na geração de dados e análise de cunho etnográfico, no contexto de um curso de imersão on-line ofertado no âmbito do projeto Núcleo de Apoio à Aprendizagem Intercultural de Português como Língua Adicional e de Acolhimento (NAAIPLAA), em ações de docência compartilhada (LEMOS, 2014; SCHLATTER; COSTA, 2020). A turma é constituída por 30 estudantes e as professoras são graduandas e egressas do curso de Letras da Universidade Federal do Pampa (Unipampa), com experiências presenciais em ensino de PLAc. Neste artigo, discutimos um evento de formação em que a análise linguística se torna relevante durante uma aula síncrona via Google Meet. Os resultados mostram que práticas que envolvem a análise linguística intercultural se caracterizam pela reflexão colaborativa sobre estranhamentos ocasionados pelos usos linguísticos, o que impacta a aprendizagem de alunos e professoras. Os resultados também apontam para preponderância da participação dos estudantes em eventos de formação, em aulas de PLAc que visam à análise linguística intercultural, e indicam que a análise linguística se concretiza como intercultural em ações interacionais entre professores e estudantes, gerando aprendizagens para todos os participantes.
O fórum online como ferramenta para interação entre alunos e aprendizagem do Português como segunda língua
Authors: Silva Vanessa Freitas da
Published: October 2021

Este artigo apresenta os resultados de um estudo que objetivou investigar as potencialidades dos fóruns on-line num contexto de aprendizagem do Português como Segunda Língua (PL2). Os dados coletados são provenientes de quatro fóruns realizados no ambiente virtual Moodle e consistem em postagens de aprendizes de diferentes nacionalidades matriculados em um curso presencial oferecido por uma universidade privada do Rio de Janeiro em 2019. Entendemos que o fórum virtual é uma ferramenta por meio da qual se pode promover a interação entre colegas e maximizar a aprendizagem fora do ambiente da sala de aula. Os resultados mostraram que os participantes trocaram informações culturais, utilizaram vocabulário adequado, empregaram estruturas linguísticas e estratégias conversacionais estudadas anteriormente e contribuíram para a construção de conhecimentos. No entanto, os fóruns realizados não foram capazes de atrair todos os alunos e aumentar a participação em comparação com as discussões face a face da sala de aula tradicional. Esse resultado pode sugerir que, apesar de instruções claras, ênfase nos objetivos, planejamento e variedade de tópicos, a participação depende da personalidade do aluno e de suas preferências relacionadas à aprendizagem.
PPORTAL: Public Domain Portuguese-language Literature Dataset
Authors: Silva Mariana O. , Scofield Clarisse , Moro Mirella M.
Published: October 2021

Combining human expertise with book-consumers data may generate what is needed to sustain constant changes experienced in the book publishing market. Then, building and making available datasets that entirely comprise the essential elements of the book industry ecosystem is essential. However, little has been done in such a context for non-English languages, such as Portuguese. Hence, we introduce PPORTAL, a public domain Portuguese-language literature dataset composed of books-related metadata. After an overview of its building process and content, we discuss a brief exploratory data analysis to summarize its main characteristics. We also highlight potential applications, showing how PPORTAL is useful as a resource on different research domains.
Covid Data Analytics: Repositório de Dados Provenientes de Múltiplas Fontes sobre a Pandemia de COVID-19 no Brasil
Authors: Moreira Pedro , Fonseca Rodrigo , Alzamora Pedro Loures , Franco Ramon A. S. , Guiginski Janaina , Cunha Evandro L. T. P. , Bernardes Tereza , Chagas Bruno , Ferregueti Kícila , Passos Luana , Cardoso Luísa , Schneider Raquel , Pereira Wallace , da Silva Ana Paula Couto , Meira Jr. Wagner
Published: October 2021

Este artigo apresenta a construção e publicação de um repositório de dados utilizados e desenvolvidos no âmbito do projeto Covid Data Analytics (CDA), executado pelo Departamento de Ciência da Computação da UFMG. O projeto visou monitorar aspectos referentes à situação social, econômica e epidemiológica da COVID-19 no Brasil a partir da análise de dados provenientes de fontes oficiais e não oficiais, de redes sociais online e da web em geral. A construção do repositório, contendo 18 atributos e 1086 registros, se baseou na coleta direta de dados das fontes selecionadas, os quais foram posteriormente enriquecidos e, finalmente, disponibilizados por meio de uma ferramenta de busca desenvolvida exclusivamente para eles.
Central de Fatos: Um Repositório de Checagens de Fatos
Authors: Couto João M. M. , Pimenta Breno , M. de Araújo Igor , Assis Samuel , Reis Julio C. S. , da Silva Ana Paula C. , Almeida Jussara M. , Benevenuto Fabrício
Published: October 2021

Recentemente, o interesse por frentes de pesquisa analisando os mecanismos, bem como maneiras de evitar a disseminação de desinformação aumentou significativamente. Neste cenário, um recorrente obstáculo a indisponibilidade de checagens de fatos. Neste trabalho, compilamos uma extensa coleção de checagens oriundas de importantes agências de checagem de fatos brasileiras. Oferecemos à comunidade cientifica uma coleção inédita contendo checagens de diversas fontes confiáveis que abrangem um largo espectro de tópicos. Ao todo, a coleção resultante engloba 11647 instâncias de checagem de fatos coletadas em 6 agências diferentes que podem ser utilizadas em diversos estudos nos contexos de identificação e combate à desinformaço em plataformas digitais no Brasil.
Uma Arquitetura de Rede Neural Convolucional Simplificada para Reconhecimento da COVID-19 em Imagens de Raios-X
Authors: Barbosa Fabio J. , Coelho Alessandra M. , Baffa Matheus F. O.
Published: October 2021

A COVID-19 é um problema emergente que já causou grandes prejuízos à sociedade. Um diagnóstico preciso auxilia no encaminhamento do paciente a um tratamento mais adequado. Na literatura da Visão Computacional, muitos trabalhos implementam arquiteturas robustas de aprendizagem profunda para criação de modelos de classificação da COVID, este trabalho visa simplificar uma Rede Neural Convolucional de forma a reduzir o custo computacional, sem perder o desempenho na detecção da COVID-19 em imagens de Raios-X. Com três camadas de convolução, o trabalho desenvolvido obteve uma acurácia de 99,36% de acurácia.
DinoApp: aplicativo para apoio ao tratamento de crianças com câncer
Authors: Silveira e Silva João Pedro , Cademartori Mayra Camargo , Duarte Victória De Avelar , Michalowski Mariana Bohns , Cota Érika
Published: October 2021

Este artigo apresenta o DinoApp, um aplicativo mobile desenvolvido para apoiar o atendimento médico de crianças com câncer. O DinoApp leva informações sobre a doença e o tratamento. Para as crianças, essas informações são apresentadas de forma lúdica. O aplicativo também oferece um canal de comunicação entre a família e a equipe médica, além de uma agenda para o controle de procedimentos médicos no período pós-internação. O DinoApp é um protótipo desenvolvido para ajudar a aumentar o engajamento do paciente durante o tratamento do câncer pediátrico.
Coronary Artery Disease Automatic Classification
Authors: Freitas Samuel A. , Costa Cristiano A. da , Ramos Gabriel De O.
Published: October 2021

Atherosclerosis represents the restriction of blood ﬂow in the heart muscle and is one of the main causes of death in the world. The assessment of atherosclerosis is challenging and is currently evaluated by the Fractional Flow Reserve (FFR) and the Quantitative Flow Ratio (QFR). Both exams are based on angiography, which is the gold standard for geometrical assessment. This study presents a pipeline to automatically determine the presence of narrowing in the right coronary artery (RCA) angiography exams, segmenting the artery silhouette, selecting regions of interest (ROIs) followed by a classification model. Initial results suggest a valid sequence of steps to classify the lesion, but require some improvements in the network architecture for better classification accuracy.
Estudo espaço-temporal do suicídio: uma pesquisa bibliográfica sobre técnicas
Authors: Dada Sheila G. , Rodrigues Mônica A. , C. Junior Etienne A. , Barrozo Ligia V. , Scanavino Marco T. , Saldiva Paulo H. N. , Saraiva Antonio M.
Published: October 2021

No mundo, aproximadamente 800.000 pessoas se suicidam a cada ano. Para desenvolver planos de prevenção ao ato, é interessante identificar as subpopulações com risco de crescimento da taxa. Neste artigo, apresentase uma revisão bibliográfica sobre as técnicas em ciência de dados abordadas sobre o tema. A abordagem foi dividida em seis etapas: definição dos dados, método de cálculo da taxa de suicídio, análise descritiva, análise espacial, análise temporal e análise multivariada. Em cada etapa, são apresentadas as técnicas utilizadas.
Transação segura de informações médicas usando BigchainDB
Authors: Klein Aldair C. D. , Baloneker Cleiton S. , Pelegrino Matheus C. , Lazarin Nilson M.
Published: October 2021

O uso do BigchainDB em aplicações de saúde pode possibilitar a descentralização e facilitar o controle de acesso. Este trabalho apresenta uma proposta para transação de dados médicos, utilizando técnicas de segurança, visando garantir a privacidade e o controle de acesso. Dessa forma, além da imutabilidade dos dados garantido pela blockchain, é possível a garantir o acesso somente ao paciente e aos profissionais por ele autorizados.
SASO: Sistema de Apoio à Saúde Ocupacional
Authors: França Isabela F. , Pereira Antônio E. , Silva Melyssa M. G. , Cordeiro Bruna M. O. S. , Junior Iwens G. Sene , Bulcão-Neto Renato F.
Published: October 2021

A população economicamente ativa passa, em média, cerca de um terço de seu tempo no local de trabalho e os problemas de saúde aí causados resultam em perdas econômicas para a maioria dos países. Considerando que a qualidade do ar é um dos principais problemas de saúde pública, é fundamental que haja um monitoramento constante nos locais de trabalho. Assim, este artigo tem como objetivo apresentar o Sistema de Apoio à Saúde Ocupacional (SASO) que consiste em uma solução IoT que monitora, em tempo real, a qualidade do ar em ambientes internos e climatizados, disponibilizando as informações coletadas em um painel para o usuário final .
Poderosa no Parto: demonstração do protótipo de aplicativo para o pré-natal
Authors: Lopes Luiz Jr da Silva , Silva Emilly G. M. da , Andrade Neusa , Messias Claudia M. , Cruz Isabel C. F. Da
Published: October 2021

Em razão do risco de infecção pela crise no setor de saúde devido à pandemia de Covid-19, a pessoa gestante tem o cuidado pré-natal restrito e sem acesso presencial ao cuidado sobre o método psicoprofilático para o enfrentamento do desconforto durante o trabalho de parto. O objetivo deste trabalho é demonstrar o protótipo do aplicativo "Poderosa no Parto", que busca promover o ensino-aprendizagem-avaliação do método psicoprofilático para ajudar a pessoa gestante na preparação para o parto ativo e natural.
Small Molecule/HLA Complexes Alter the Cellular Proteomic Content
Authors: Toni Hò Gia-Gia , Hiemisch Wiebke , Pich Andreas , Matern Michelle , Sophi Gräser Lareen , Blasczyk Rainer , Bade-Doeding Christina , Sabrina Simper Gwendolin
Published: October 2021

A medical product usually undergoes several clinical trials, including the testing of volunteers. Nevertheless, genomic variances in the patients cannot be considered comprehensively and adverse drug reactions (ADRs) are missed or misinterpreted during trials. Despite the relation between ADRs and human leukocyte antigen (HLA) molecules being known for several years, the fundamental molecular mechanisms leading to the development of such an ADR often remains only vaguely solved. The analysis of the peptidome can reveal changes in peptide presentation post-drug treatment and explain, for example, the severe cutaneous ADR in HLA-B*57:01-positive patients treated with the antiretroviral drug abacavir in anti-HIV therapy. However, as seen in the biophysical features of HLA-A*31:01-presented peptides, treatment with the anticonvulsant carbamazepine only induces minor changes. Since the binding of a drug to a certain HLA allelic variant is extremely distinct, the influence of the small molecule/protein complex on the proteomic content of a cell becomes clear. A sophisticated methodology elucidating the impact of drug treatment on cells is a full proteome analysis. The principal component analysis of abacavir, carbamazepine or carbamazepine-10,11-epoxid treated cells reveals clear clustering of the drug-treated and the untreated samples that express the respective HLA molecule. Following drug treatment, several proteins were shown to be significantly up- or downregulated. Proteomics and peptidomics are valuable tools to differential clinical outcomes of patients with the same HLA phenotype.
Informality and Entrepreneurship in Developing Economy: Case for Entrepreneurial Financing
Authors: Omotosho Sule
Published: October 2021

Over a decade ago, scholars in different domains of knowledge such as strategic management, economics, accounting, and finance have largely contributed to the theoretical and empirical studies of entrepreneurial financing. However, bridging of the domains or the theories that underly the domains, and expanding the frontier of the phenomenon in the context of informal entrepreneurship, are missing in the literature. This paper attempts to conceptualise and problematise various issues that confront informal sector entrepreneurship in accessing adequate financing for start-up opportunity, innovative products, services and technology in the informal markets, and explore how the ambiguity of the diverse domains of knowledge of entrepreneurial financing could be resolved by unifying and integrating the domains within a unique framework. Equally, this paper also aims to provide theoretical contributions to the extant literature of entrepreneurial financing by suggesting how management accounting research can bridge the gaps of informality problems that confront informal entrepreneurial financing. There is no doubt that informal businesses are saddled with legitimacy concerns such as non-conformity with legality and institutionalised policies. Similarly, the sector is also confronted with the issues of information asymmetry, moral hazard conflict, informal financial and ownership structure. Nonetheless, the informal entrepreneurship sector unarguably has a relevance to the opportunity discovery and innovativeness dimensions of entrepreneurial orientation, with the consequence of positive contributions to the economy in terms of large-scale employment growth. Hence, the scholars in the accounting discipline can leverage on the emerging different financial technology and fund providers to expand the literature on how the untold hardships and complexity that surround the funding of informal entrepreneurial start-ups and innovation can be mitigated. Management accounting discipline, being an applied field of strategic management can play vital roles in mitigating the aforesaid problems of informal entrepreneurship funding, if it could focus on expanding the literature or methodology on goal congruence, information management and controls, financial contracting model, incentive modelling for regulatory policy and search and match model that focuses on informal entrepreneur, investors and financial intermediaries.
Omentin-1 Levels and Non-alcoholic Fatty Liver Disease in Obese Adolescents
Authors: Turkkan Emine , Dag Huseyin , Dikker Okan , Dag Nevin Cetin , Kacar Alper , Sazak Soner
Published: October 2021

Background: Omentin-1 is an adipocytokine secreted from visceral adipose tissue that is thought to increase insulin sensitivity. Non-alcoholic fatty liver disease (NAFLD) is a comparatively extensive problem in obese adolescents. Decreased omentin-1 levels have been reported in obese patients, but the relationship between NAFLD and omentin-1 is contradictory. Objectives: We aimed to evaluate the omentin-1 levels in the sera of obese adolescents with and without NAFLD and compare them with each other. Methods: In this study, a total of 88 adolescents (56 obese and 32 normal-weight) were enrolled. Abdominal ultrasonography (US) identified 28 obese adolescents with grade 2 - 3 hepatosteatosis constituting the NAFLD group and 28 without hepatosteatosis on US constituting the non-NAFLD group. The control group included 32 age- and gender-matched cases without hepatosteatosis and with normal percentile body mass index (BMI). Serum omentin-1 levels were evaluated and compared. Results: The mean age of the research group was 12.72 ± 1.91 years. Unsurprisingly, BMI, glycated hemoglobin (HbA1c), liver transaminases (AST, ALT), total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL), homeostatic model assessment for insulin resistance (HOMA-IR), and insulin rates were noticeably elevated in obese adolescents compared to controls (P < 0.05). However, omentin-1 and high-density lipoprotein cholesterol (HDL) levels were remarkably lower in the obese group (P < 0.05). No significant difference was found between the NAFLD and non-NAFLD groups regarding omentin-1, HbA1c, glucose, urea, creatinine, AST, C-reactive protein (CRP), total cholesterol, triglyceride, HDL, LDL, thyroid stimulating hormone, 25-hydroxyvitamin D3, HOMA-IR, and insulin. The BMI and ALT grades of the non-NAFLD group were notably lower than the NAFLD group (P < 0.05). While there was no significant difference between omentin-1 and other parameters in obese adolescents without NAFLD (P > 0.05), we found a significant difference between omentin-1 and BMI, AST, ALT, HOMA-IR, and insulin values in obese adolescents with NAFLD (P < 0.05). Conclusions: Omentin-1 levels were decreased in obese adolescents regardless of the presence of NAFLD. However, in obese patients with NAFLD, there was a significant difference between omentin-1 and several markers of obesity and insulin resistance.
Realismo Semântico e Consciência do Momento
Authors: Monteiro João Paulo ,   Philosophy Documentation Center
Published: October 2021

An article by Moulines presents an interesting argument against semantic realism, using Calderôn’s play La Vida en Sueño as a literary device to develop his point. He introduces in the play a new character, a realist philosopher who tries to persuade Prince Segismund to abandon the anti-realist position he maintains, after the experience he undergoes in the play. I introduce a second imaginary realist, who argues for conjectural realism instead of the semantic variety, by means of several sceptical arguments intended to defeat scepticism itself, throwing it in the same boat as anti-realist solipsism.
A Eudaimonia no Livro I da Ética a Nicómaco
Authors: Castanheira Nuno ,   Philosophy Documentation Center
Published: October 2021

The concept of eudaimonia put forward by Aristotle in the first Book of his Nicomachean Ethics reflects an attempt to synthesize and clarify a well known concept in the Greek society, in popular as well as in more restricted intellectual circles, giving it a new scope and conceptual consistency. Ordinarily translated as happiness, well-being or prosperity, this concept frequently had a subjective sense, describing the lives of those who lived well or were eudaimon; but it also had an objective sense, establishing a life conducting rule for everyone who wanted to be happy or eudaimon. In the present paper we give an account of the meaning and operative range of the concept of eudaimonia and show the eudaimonia's guiding role in the Aristotelian ethical project, namely as its founding principle and final horizon, its relations with the good and virtue, as well as with the nature of man and the generation of a new modality of being. Finally, we establish that the concept of eudaimonia is central to an ethics seen as a life project.
Ciudadanía Intercultural
Authors: Cortina Adela ,   Philosophy Documentation Center
Published: October 2021

Ce texte expose le concept de citoyenneté dans son double aspect - descriptif et prescriptif. Aux dimensions civiles, politiques et sociales de la citoyenneté il faut ajouter deux autres: l’économique et la culturelle. Ce qui fait tenir en compte le problème du multiculturalisme et de la citoyenneté multiculturelle. Il faut trouver des réponses qui permettent aux différentes éthnies une façon de vivre ensemble. Dans ce but, l’article analyse critiquement trois possibilités: le libéralisme multiculturel de Klymcka; le libéralis me intolérant de Sartori et le libéralisme radical interculturel. Ce dernier est la position choisie et soutenue dans le texte qui vise souligner le caractère dynamique des différentes cultures, bien que l’influence bénéfique qu’elles provoquent les unes sur les autres.
As Corese a Instituição da Ordem no Mundo do Antigo Regime
Authors: Hespanha António Manuel ,   Philosophy Documentation Center
Published: October 2021

The colors are one of the most expressive examples of social and personal construction of meanings (if not of the reality itself). The diverse cultures have seen different colors in the rainbow, they have organized differently their sequence in it, but, overall, they have loaded them with different symbolic contents. Frequently, colors are markers of the social and political hierarchies and, therefore, “matter of law”. In the second half of the 18th Century, a disciple of Christian Thomasius summarizes, in a university dissertation, the common legal prescriptions on the use of the colors. Old literal genealogies still stand, entangled with scientific opinions of the time. On the basis of this intertext, legal doctrine fixes and multiplies meanings over space and time, as a huge space of industrial symbolic production. In such a way that, in spite of the changes brought by romantic imagery and by the emergent industrial revolution in the techniques of coloring, we can still recognize some glimpses of the shattered world of colors of traditional Europe.
Filosofia e Literatura. O Paradigma Bonaventuriano
Authors: Rocha Martins António Joaquim ,   Philosophy Documentation Center
Published: October 2021

This paper analyses (1) the power of metaphor which is central to Bonaventure’s literary expression, his spirituality, his philosophical and theological speculation; (2) Considers which human language is ultimately a participation in divine expressionism; (3) Analyses the notion of metaphor in Bonaventure’s treatment of human language; (4) Expose his contribution for the «linguistic turn». All of this will support the thesis of this paper: that language as expression is the most fundamental metaphysical/ontological/poetic notion in Bonaventure’s vision.
Relativismo na Avaliação de Execuções Musicais
Authors: Lopes António ,   Philosophy Documentation Center
Published: October 2021

As in other domains of art, the assessment of performances or interpretations of musical works is largely considered as a matter of personal taste. In Evaluating Musical Performance, Jerrold Levinson argues that relativism, in this matter, depends on the many interests with which a performance can be faced, and, consequently, evaluated and assessed. My thesis in this article is that not all interests have the same importance and that there is a “purely musical” perspective that must prevail over the other interests. This way I try to diminish the so called relativism.
Morphology and zoogeography of the burrower-like gammarid Gammarus koshovi (Bazikalova, 1946) (Crustacea, Amphipoda, Gammaridae) – An overlooked and poorly known species in the Siberian fauna
Authors: Sidorov Dmitry , Yalysheva Elena , Sharyi-Ool Mariana
Published: October 2021

A comprehensive survey of several lakes in the Tuva Republic of Russia yielded, besides the ubiquitous Gammarus lacustris, the discovery of a small freshwater, lacustrine amphipod not previously recorded in this area. A comparative study of the Tore-Khol Lake gammarid population, probably conspecific with Gammarus koshovi (Bazikalova, 1946) originating from Khubsugul Lake, was conducted. The species, G. koshovi, is characterized by a specific habitus: a small-sized compact body, all limbs shortened, carpi of pereopods (PIII and PIV) reduced, coxal plates broad, and pereopod dactyli sturdy. It has been suggested that juveniles of the euryoecious G. lacustris or other large species could be confused with the relatively small G. koshovi. Consequently, we decided to present the distribution of gammarid species throughout south Siberia and Mongolia, referring to the sequences of works primarily by Soviet authors, which may be hard to access by international readers. We discuss affinity with related groups, distribution, and ecology of G. koshovi to better understand their evolution. Additionally, the zoobenthic species diversity of widely represented groups in the ecosystems of Tore-Khol Lake is briefly reviewed. An identification key for the Siberian Gammarus with 10 species is provided.
Intervención de emergencia en formato online basado en act en un caso de Trastorno Adaptativo
Authors: Mohd Tarifa Javier , Cerezo Carrizo Laura , Carrasco Miguel Ángel
Published: October 2021

El presente artículo tiene como objetivo exponer el abordaje clínico de un usuario del Servicio de Psicología Aplicada de la de la Facultad de Psicología de la UNED atendido durante la situación de Emergencia Sanitaria Covid-19. Se trata de un estudio de caso N = 1 de un varón de 22 años (F.) cuya sintomatología se ajusta a un trastorno adaptativo con ansiedad mixta y estado de ánimo deprimido. Tras la evaluación del caso mediante entrevista no estructurada y autorregistros del paciente, se llevó a cabo una intervención breve protocolarizada con modalidad online. La aproximación terapéutica llevada a cabo fue la Terapia de Aceptación y Compromiso (ACT), que incluyó diferentes estrategias dirigidas a que F. pudiera discriminar su patrón de conducta problemático, aceptar los eventos privados aversivos y pudiera emprender acciones con significado personal. Los resultados mostraron un aumento de conductas adaptativas en las áreas que F. consideraba valiosas, y una disminución de la sintomatología ansiosa y depresiva. En el apartado final, se discuten las limitaciones de la intervención derivadas del contexto en el que fue realizada.
Malestar, afrontamiento e intervención en la pareja durante el confinamiento por el COVID-19
Authors: Martorell José Luis
Published: October 2021

En el presente trabajo se aborda el impacto que el confinamiento impuesto por la pandemia del COVID-19 ha tenido sobre la pareja. Se presentan los resultados de los primeros estudios publicados sobre la relación de pareja en el confinamiento y se analizan los elementos específicos del confinamiento que afectaron a dicha relación. Se describen los elementos y las características de los conflictos que presentaron las personas que demandaron atención psicológica y se describen las intervenciones que se realizaron, resaltando la utilidad en este tipo de intervenciones del concepto de distancia emocional ideal.
Considerations for Use of Hematopoietic Growth Factors in Patients With Cancer Related to the COVID-19 Pandemic
Authors: Griffiths Elizabeth A. , Alwan Laura M. , Bachiashvili Kimo , Brown Anna , Cool Rita , Curtin Peter , Geyer Mark B. , Gojo Ivana , Kallam Avyakta , Kidwai Wajih Z. , Kloth Dwight D. , Kraut Eric H. , Lyman Gary H. , Mukherjee Sudipto , Perez Lia E. , Rosovsky Rachel P. , Roy Vivek , Rugo Hope S. , Vasu Sumithira , Wadleigh Martha , Westervelt Peter , Becker Pamela S.
Published: October 2021

Hematopoietic growth factors, including erythrocyte stimulating agents (ESAs), granulocyte colony-stimulating factors, and thrombopoietin mimetics, can mitigate anemia, neutropenia, and thrombocytopenia resulting from chemotherapy for the treatment of cancer. In the context of pandemic SARS-CoV-2 infection, patients with cancer have been identified as a group at high risk of morbidity and mortality from this infection. Our subcommittee of the NCCN Hematopoietic Growth Factors Panel convened a voluntary group to review the potential value of expanded use of such growth factors in the current high-risk environment. Although recommendations are available on the NCCN website in the COVID-19 Resources Section (https://www.nccn.org/covid-19/), these suggestions are provided without substantial context or reference. Herein we review the rationale and data underlying the suggested alterations to the use of hematopoietic growth factors for patients with cancer in the COVID-19 era.
A Hospital-Wide Intervention to Improve Compliance With TNM Cancer Staging Documentation
Authors: Lee Jason H. , Mohamed Tariq , Ramsey Celia , Kim Jihoon , Kane Shelly , Gold Kathryn A. , Faraji Farhoud , Califano Joseph A.
Published: October 2021

Background: Accurate oncologic staging meeting clinical practice guidelines is essential for guideline adherence, quality assessment, and survival outcomes. However, timely and uniform documentation in the electronic health record (EHR) at the time of diagnosis is a challenge for providers. This quality improvement project aimed to increase provider compliance of timely clinical TNM (cTNM) or pathologic TNM (pTNM) staging for newly diagnosed oncologic patients. Methods: Providers in the following site-specific oncologic teams were included: head and neck, skin, breast, genitourinary, gastrointestinal, lung and thoracic, gynecologic, colorectal, and bone marrow transplant. Interventions to facilitate timely cTNM and pTNM staging included standardized EHR-based workflows, learning modules, stakeholder meetings, and individualized provider training sessions. For most teams, staging was considered compliant if it was completed in the EHR within the first 7 days of the calendar month after the date of the patient visit. Factors associated with staging compliance were analyzed using logistic regression models. Results: From January 1, 2014, to December 31, 2018, 7,787 preintervention and 5,152 postintervention new patient visits occurred. During the preintervention period, staging was compliant in 5.6% of patients compared with 67.4% of patients after intervention (P<.001). In the final month of the postintervention period, the overall staging compliance rate was 78.1%. At most recent tracking, staging compliance was 95%, 97%, and 93% in December 2019, January 2020, and February 2020, respectively. Logistic regression found that increasing years of provider experience was associated with decreased staging compliance. Conclusions: High rates of staging compliance in complex multidisciplinary academic oncologic practice models can be achieved via comprehensive quality improvement and structured initiatives. This approach serves as a model for improving oncologic documentation systems to facilitate clinical decision-making and multidisciplinary coordination of care.
Efficacy and Toxicity Analysis of Capecitabine and Temozolomide in Neuroendocrine Neoplasms
Authors: Al-Toubah Taymeyah , Pelle Eleonora , Valone Tiffany , Haider Mintallah , Strosberg Jonathan R.
Published: October 2021

Background: The capecitabine/temozolomide (CAPTEM) regimen has significant activity in advanced neuroendocrine tumors (NETs). Questions exist regarding activity in pancreatic versus nonpancreatic NETs, risk of opportunistic infections, long-term myelotoxicity, and safety of prolonged treatment duration. Analysis of large patient cohorts is needed for the evaluation of rare toxicities and assessment of risk factors. Methods: We conducted a retrospective study of all patients with advanced NETs seen at Moffitt Cancer Center between January 2008 and June 2019 who received treatment with CAPTEM. Results: A total of 462 patients were eligible. The objective radiographic response rate was 46%, and the disease control rate was 81%. Median progression-free survival (PFS) was 18 months (95% CI, 14.0–21.9 months) and median overall survival was 51 months (95% CI, 42.8–59.2 months): 62 months in well-differentiated NETs versus 14 months in poorly differentiated neuroendocrine carcinomas (P<.0001). Patients with primary pancreatic tumors had the highest partial response rates and longest median PFS. Incidences of grade 4 thrombocytopenia and neutropenia were 7% and 3%, respectively, and substantially higher in women than men (P=.02 and P=.004, respectively). Only 1 case (0.2%) of suspected Pneumocystis pneumonia (PCP) was observed in a patient receiving corticosteroids. Three patients developed myelodysplastic disease, all of whom had received prior peptide receptor radiotherapy (PRRT). There were no acute treatment-related deaths; 1 patient died 2 months after a thrombocytopenic bleed. Conclusions: The CAPTEM regimen is exceptionally safe. Efficacy is particularly robust in well-differentiated pancreatic NETs. Severe myelotoxicity is rare; the risk of grade 4 cytopenias is significantly increased in women, and therefore sex-based dosing should be considered. There were no cases of myelodysplastic syndromes, except among patients who had received PRRT, a known risk factor. The risk of PCP is negligible.