bluuebunny/crossref_metadata_2025 huggingface dataset:
Hyperkeratosis lenticularis perstans (Flegel´s disease)
Authors: Kuokkanen K. , Alavaikko M. , Pitkänen R.
Published: August 2023

A 62-year-old female with a 20-year history of small horny papules on the skin of the legs is described. Light microscopy revealed a hyperkeratotic papule with atrophic epidermis and a dense dermal inflammatory cell infiltrate with many cerebriform lymphocytes not earlier described in connection with hyperkeratosis lenticularis perstans (HLP). The electron-microscopic picture showed membrane-coating granules (MCG) and keratohyalin located in different cells, indicating that the disorder of keratinization in HLP is possibly caused by reduced co-operation between these cells and that the keratinization process occurs in the absence of MCG. Perpetual treatment with oral retinoid was successful.
Psoriasis pustulosa treated with methotrexate and leucovorin
Authors: Kavli G. , Volden G.
Published: August 2023

No abstract available.
Imbalance in phenotypic expression of T cell subpopulations during different evolutional stages of lichen planus lesions
Authors: De Panfilis G. , Manara G. , Ferrari C. , Manfredi G. , Allegra F.
Published: August 2023

Immunoenzymatic (in light and in electron microscopy) and immunofluorescence techniques were performed, using monoclonal antibodies, on tissue sections of early lichen planus (LP) lesions versus late LP lesions from 20 patients. Control procedures were carried out in peripheral blood T cells from the same patients and from healthy donors. The OKT4-Leu3A/OKT8-Leu2A ratio in peripheral blood from LP patients and from donors was lower than in dermal infiltrate of early LP lesions, but higher than in dermal infiltrate of late LP lesions. It is conceivable that in early LP lesions OKT4-Leu3A-positive cells may be antigen-specifically ´educated´ by immunostimulatory cells. In late LP lesions, OKT8-Leu2A-positive cells could be cytotoxic to keratinocytes; it is likely, however, that this latter population may moreover have immunoregulatory, resolutional functions.
Sebaceous glands changes following topical application of citral
Authors: Abramovici A. , Wolf R. , Sandbank M.
Published: August 2023

The long-lasting effect of a flavour cosmetic constituent on male rat skin was studied. Topical daily application of citral (15.4%) solution for 3 months produced an increase in the number of sebaceous gland lobules and hyperplasia of sebaceous cells in each gland. It is suggested that the mechanism of this hyperplasia might be activation of the testosterone 5 alpha-reductase which induces the formation of dihydrotestosterone, the mediator of sebaceous gland activity.
Subcorneal pustular dermatosis--an unusual course
Authors: Halevy S. , Ingber A. , Feuerman EJ.
Published: August 2023

In a patient with subcorneal pustular dermatosis (SPD) the appearance of new pustular lesions characteristic of the disease was triggered by two episodes of drug eruption (induced by dapsone and quinidine sulphate respectively) and by the intra-dermal injection of the recall antigens Candida and streptokinase-streptodornase, performed for evaluation of delayed hypersensitivity. Both episodes of drug eruption were probably the result of an immediate-type hypersensitivity reaction towards the offending drugs, as indicated by positive mast cell degranulation tests.
Central nervous system involvement in early syphilis. Part II. Correlation between auditory brain stem responses (ABR) and cerebrospinal fluid abnormalities
Authors: Löwhagen GB. , Rosenhall U. , Andersson M. , Blomstrand C. , Lindholm L. , Roupe G.
Published: August 2023

Twenty-six consecutive patients with secondary or early latent syphilis, all with normal neurological findings, were studied with auditory brainstem responses (ABR), cerebrospinal fluid (CSF) analysis and an assay for immune complexes in serum and CSF. Seven of the 26 patients studied had a pathological ABR pattern and 14 had one or more pathological CSF tests. Fifteen patients had circulating immune complexes in serum. No patient had demonstrable immune complexes in CSF. A significant correlation was found between an abnormal ABR pattern and pathological CSF findings--but not between pathological ABR and presence of immune complexes. ABR seems to be a sensitive method for detection of early asymptomatic CNS involvement in syphilis.
Bullous and pustular rheumatoid vasculitis: treatment by plasma exchange
Authors: Ortonne JP. , Cassuto-Viguier E. , Quaranta JF. , Lacour JP. , Ziegler G.
Published: August 2023

A case of rheumatoid vasculitis (RV) with bullous and pustular lesions is reported. These skin manifestations represent very unusual symptoms of RV. A dramatic clinical improvement was obtained by plasma exchange and immunosuppressive therapy.
Is X-ray necessary to diagnose aberrant skin and subcutaneous calcifications?
Authors: Hagdrup H. , Serup J. , Brun B.
Published: August 2023

No abstract available.
Bilateral follicular basal cell nevus with comedo-like lesions
Authors: Crivellato E. , Trevisan G. , Grandi G. , Lepore L.
Published: August 2023

A 12-year-old white boy presented with symmetrically appearing papular, nodular, comedo-like, highly itching lesions involving the skin on his ankles. They had first appeared 3 years earlier. Numerous cutaneous biopsies showed tumoral buds of basalioma cells associated with follicular structures, infundibular cysts and also hypertrophy and hyperplasia of sebaceous glands. To the best of our knowledge, there are no reported cases with the same clinical and histopathological findings as in those reported here. We believe the lesions represent a "bilateral follicular basal cell nevus with comedones".
Treatment of localized scleroderma and lichen sclerosus with etretinate
Authors: Neuhofer J , Fritsch P.
Published: August 2023

Eight patients with lichen sclerosus and 8 patients with localized scleroderma were treated with etretinate (Tigason) at doses of 0.5 mg/kg body weight for between 3 and 12 months: 2 of 3 patients with juvenile type lichen sclerosus cleared, whereas the lesions of 5 patients with balanitis xerotica obliterans, kraurosis vulvae and extragenital lichen sclerosus were unchanged or even progredient. 2 of the patients with localized scleroderma cleared with slight atrophy. The lesions of 5 others failed to resolve but progression was halted under continued therapy; after drug withdrawal, the lesions resumed progression in 2 patients. We conclude that only moderate therapeutic effects can be achieved with etretinate in both lichen sclerosus and localized scleroderma.
The influence of urea on the penetration kinetics of topically applied corticosteroids
Authors: Wohlrab W.
Published: August 2023

The effect of urea on the penetration of hydrocortisone and triamcinolone acetonide into human skin from topically applied vehicles was studied. The resulting penetration promotion has two possible applications in topical therapy: (a) An increased therapeutic effect for a given concentration of the active constituent. (b) A given therapeutic effect could be obtained with a reduced concentration of the active ingredient.
The spirochetal etiology of erythema chronicum migrans Afzelius
Authors: Asbrink E , Hederstedt B , Hovmark A.
Published: August 2023

We have obtained spirochetes from Ixodes (I.) ricinus ticks collected in different areas in Stockholm where erythema chronicum migrans Afzelius (ECMA) cases are known to occur sporadically. Titers of antibody against spirochetal isolates, cultured in modified Kelly´s medium, from Swedish I. ricinus and American I. dammini ticks were determined by indirect immunofluorescence. With the I. ricinus respectively the I. dammini spirochete as antigen the ECMA group had a significantly higher median titer (73 respectively 128) than the control group (28 respectively 31). Spirochetes have also been isolated from the periphery of one ECMA lesion by injecting skin homogenates into rabbit testicles. The findings are in agreement with spirochetal etiology in ECMA.
Vascular effects of a local anesthetic mixture in atopic dermatitis
Authors: Juhlin L , Rollman O.
Published: August 2023

An anesthetic cream with an eutectic mixture of 5% lidocaine and 5% prilocaine has been tested on the skin of healthy subjects and patients with atopic dermatitis and generalized eczema. In healthy subjects a blanching was seen when the analgesia was complete after 30-60 min. In the dry skin and eczematous lesions of atopic dermatitis an application time of 5-15 min caused a blanching and a good analgesia. When applied for 30-60 min the eczematous skin became increasingly red and in one patient purpura appeared. The white dermographism turned red in treated areas. The abnormal vascular reactions to the cream in diseased skin can be explained by a rapid and increased percutaneous absorption of the anesthetics. A shortened application time is here recommended.
Lymphomatoid papulosis: a follow-up study
Authors: Lange-Wantzin G , Thomsen K , Hou-Jensen K.
Published: August 2023

A follow-up study has been performed on 16 patients with lymphomatoid papulosis diagnosed at the Finsen Institute during the years 1970-81. In none of the patients did malignant lymphoma develop during the observation period (7 months to 22 years). During this period the nature of the lesions and the tendency to recurrence were unchanged in 11 patients, spontaneous remission took place in 4, and 1 patient went into complete remission after PUVA treatment (8-methoxsalen followed by UVA). The histological material (32 punch biopsies) could be divided into two major groups diagnosed as either typical (16 biopsies) or consistent with lymphomatoid papulosis (16 biopsies). Based on our present knowledge, we suggest the following classification of lymphomatoid papulosis: 1) "classical" lymphomatoid papulosis, 2) lymphomatoid papulosis associated with parapsoriasis en plaque or mycosis fungoides and 3) primary cutaneous T-cell lymphoma.
The spirochetal etiology of acrodermatitis chronica atrophicans Herxheimer
Authors: Asbrink E , Hovmark A , Hederstedt B.
Published: August 2023

Spirochetes were recovered from the skin lesion of 1 out of 10 acrodermatitis chronica atrophicans patients (ACA). Spirochetes from this skin isolate and from Ixodes (I.) ricinus and I. dammini spirochetes were used as antigens in indirect immunofluorescence tests. All sera from 17 ACA patients showed high antibody titers to the three antigens. Seven of the 17 sera which had the highest titers had crossreactive antibodies to treponemal antigen detectable in the FTA-ABS test. The results indicate that spirochetes are of importance for ACA and probably the causative agent of this disease. The connection between ACA and tick bites and the relationship to erythema chronicum migrans Afzelius (ECMA) and Lyme disease are discussed. The results are consistent with the hypothesis that ECMA and ACA are different manifestations of the same spirochete, with ACA as a late manifestation.
Selenium, glutathione-peroxidase and dermatitis herpetiformis
Authors: Ljunghall K , Juhlin L , Edqvist LE , Plantin LO.
Published: August 2023

The low levels of glutathione-peroxidase in blood from patients with dermatitis herpetiformis increased after 5 months selenium and vitamin E treatment. In this double-blind study no significant clinical improvement was, however, noted.
Dapsone in the treatment of Kaposi´s sarcoma
Authors: Poulsen A , Hultberg B , Thomsen K , Lange Wantzin G.
Published: August 2023

Previously we observed clinical and histological regression of Kaposi´s sarcoma in the skin in a 38-year-old man with AIDS following treatment with Dapsone. This observation initiated the present study where 6 patients with Kaposi´s sarcoma in the skin without clinical signs of systemic spreading were treated with Dapsone 100 mg daily for four months. During this treatment clinical and histological regression of Kaposi´s sarcoma was found in three patients. In a further patient only clinical regression was found, while no regression was found in the remaining two patients with Kaposi´s sarcoma.
Antipsoriatic activity of 10-acyl analogues of dithranol (anthralin). I. Phase I clinical trial of 10-propionyl dithranol and 10-butyryl dithranol (butantrone)
Authors: Mustakallio KK , Brandt H.
Published: August 2023

Dithranol, 10-propionyl dithranol and 10-butyryl dithranol were compared as regards their antipsoriatic, staining and irritative properties. They were applied under 12-mm Finnchambers on the lesional skin of 17 psoriasis patients every second day for 20 days. In 9 patients their concentration was equimolar (2 mmol/kg of white petrolatum) corresponding to 0.05% dithranol, and in 8 patients the concentrations were 2, 4, and 8 mmol for dithranol, 10-propionyl dithranol and 10-butyryl dithranol, respectively. Without regard to the concentration, they all produced under occlusion almost equal thinning of the lesions, but when a 2 mmol concentration was used, 10-butyryl dithranol (butantrone) showed least staining and irritation on the treated sites.
The influence of the opiate antagonist naloxone on experimental pruritus
Authors: Fjellner B , Hägermark O.
Published: August 2023

The antipruritic effect of naloxone hydrochloride was evaluated in a double-blind, cross-over design. Systemic pretreatment with the opiate antagonist did not interfere with the cutaneous itch and flare responses evoked by morphine or histamine, nor did it inhibit the morphine-produced potentiation of the histamine-elicited skin reactions.
The changing clinical picture of Microsporum canis infections in Sweden
Authors: Agren-Jonsson S.
Published: August 2023

No abstract available.
Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment
Authors: Michaëlsson G , Edqvist LE.
Published: August 2023

The glutathione-peroxidase (GSH-Px) activity in erythrocytes was determined in 42 men with severe acne and 47 women with acne--26 of a moderate degree and 21 severe. The male acne patients had significantly lower GSH-Px levels than the controls. The women with acne did not differ significantly from the controls in this respect when patients and controls using oral contraceptives were excluded. Both the female controls and the women with acne using oral contraceptives had significantly higher GSH-Px values than the corresponding groups not using the pill. The pubertal acne girls had the same high GHSH-Px activity as women on oral contraceptives. In an open trial 29 patients were given 0.2 mg of selenium (as Na2Se O3) + 10 mg of tocopheryl succinate for their acne twice daily for 6-12 weeks. A good result was obtained, especially in patients with pustular acne and low GSH-Px activity, and the beneficial effect was usually paralleled by a slow rise of the GSH-Px activity. Some 6-8 weeks after withdrawal of the treatment the GSH-Px values had returned to the pretreatment levels.
Pathways of ionic flow through human skin in vivo
Authors: Grimnes S.
Published: August 2023

The pathways of electric current have been examined with special electrodes and methods. The results indicate that the flow through ordinary stratified stratum corneum is negligible, and that the dominant ionic path is through the sweat duct units. Here the cells of interest may be oriented perpendicular to the main stratified orientation of the skin, and this may affect the methods and interpretations of absorption/permeability studies.
Basement membrane components and keratin in the dominantly inherited form of cylindroma
Authors: Oikarinen A , Peltonen L.
Published: August 2023

Specific antibodies against basement membrane associated, connective tissue components: type IV and V collagens, laminin, fibronectin and heparan sulphate proteoglycan were used to study the basement membrane-like structures in cylindroma lesions. All these components were immunohistochemically demonstrated as a band surrounding islands of epithelial cells and all except fibronectin also inside the islands. Antibodies to keratin filaments stained most of the cells inside the epithelial islands confirming the epithelial origin of the cells.
Immunoglobulin E in psoriasis evaluated by paper radioimmunosorbent and paper enzyme-immunosorbent tests
Authors: Chen ZY , Ainsworth SK , Khan T , Pilia PA , Dobson RL.
Published: August 2023

Serum IgE concentrations were determined by the paper radioimmunosorbent test in 56 patients with psoriasis and 50 normal controls, and by the paper enzyme-immunosorbent test in 32 of these patients and 50 controls. Elevated IgE levels were found in 26 (46%) of 56 patients with psoriasis and in 1 normal control (2%). The mean value (208 U/ml) in 56 patients was significantly higher than in normal controls (31 U/ml). Thirteen of 19 patients (68%) with extensive involvement (greater than 20% body surface) had an increased IgE level; the mean value (365 U/ml) was 4 times greater than in 17 patients with limited lesions (89 U/ml) and 12 times higher than in 50 normal controls (31 U/ml). No correlation was found between serum IgE levels and the presence of psoriatic arthritis. Both paper radioimmunosorbent and paper enzyme-immunosorbent testing produced similar results.
Promotion of palmar sweating with oral phosphatidylcholine
Authors: Aronson PJ , Lorincz AL.
Published: August 2023

Since acetylcholine is the main neurotransmitter of eccrine sweating, phosphatidylcholine ingestion might increase sweating. In 10 adults mid-palmar sweating was measured 12 hours after ingestion of a high and a low phosphatidylcholine supper. In a double blind, crossover study, mid-palmar sweating was measured in 11 consenting adults 12 hours after a low phosphatidylcholine supper taken with either lecithin or placebo. Five minutes after cleaning the palm and drying, sweat was captured in a quick-drying plastic film. The film was removed with cellophane tape and placed on a glass slide. Mean "droplet" diameter was measured by averaging the greatest diameter of 25 "droplets." Ten of 10 subjects (100%) produced more sweat with a high phosphatidylcholine meal than with a low one. Compared to placebo, 10 of 11 subjects (91%) given lecithin had significantly increased sweat secretion (p less than 0.01). It remains to be confirmed that this phosphatidylcholine-induced sweating increase is clinically significant.
Sheet dermatitis
Authors: Tegner E.
Published: August 2023

A characteristic dermatitis with skin-coloured or erythematous papules localized to the helices and lobes of the ears and to the skin behind the ears was observed in 25 subjects who had been using new, unwashed sheets and pillow-cases containing permanent-pressing resin.
The effect of cyclophosphamide on the toxic contact reaction to croton oil in guinea pig
Authors: Anderson C , Groth O.
Published: August 2023

Cyclophosphamide is a cytostatic agent used clinically and in experimental studies for its immunosuppressant effect. Effects on the afferent and efferent limb of the contact allergic reaction have been shown. The substance has also non-specific, anti-inflammatory effects and these were investigated in this paper by studying the effects of single doses of cyclophosphamide on the toxic contact reaction to croton oil (a non-specific inflammatory reaction) in guinea pig. Counting of the dermal cellular infiltrate showed that mononuclear and granulocyte counts decreased in a dose-dependent fashion after cyclophosphamide administration. Erythema and oedema in the test reactions decreased generally, although at the highest dose a paradoxical increase was seen.
Normalization of monocyte chemotaxis precedes clinical resolution of psoriasis treated with benoxaprofen
Authors: Kragballe K , Ternowitz S , Herlin T.
Published: August 2023

Enhanced monocyte activity is present in psoriasis, and benoxaprofen is a drug that inhibits several aspects of monocyte function. To assess a potential pathogenic role of enhanced monocyte function in psoriasis, we determined monocyte chemotaxis and monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) at week 0, 2, 4 and 8 in psoriatics being treated with benoxaprofen. In patients responding to benoxaprofen, normalization of monocyte chemotaxis occurred at week 4, before clinical resolution took place. A significant decrease of monocyte ADCC was also present at week 4, but it was only at week 8, when psoriasis had completely cleared, that monocyte ADCC was completely normalized. In patients receiving placebo or receiving benoxaprofen, but showing no or minimal clinical improvement, monocyte functions remained increased. These results are compatible with the idea that benoxaprofen may improve psoriasis by interfering with monocyte function.
Vitamin D metabolites in generalized scleroderma. Evidence of a normal cutaneous and intestinal supply with vitamin D
Authors: Serup J , Hagdrup H.
Published: August 2023

Vitamin D metabolites in serum were analysed in 20 patients with generalized scleroderma. The concentration of 1,25-dihydroxyvitamin D was normal, however, significantly lower concentrations (p less than 0.05) were found in 7 patients with cutaneous calcinosis in comparison with 13 patients with no calcinosis. Concentrations of 25-hydroxyvitamin D, 24-25-dihydroxyvitamin D, and vitamin D-binding protein (Gc globulin) were all within the normal range. The 24,25-dihydroxy-vitamin D level correlated with the duration of disease (r = 0.4453, p less than 0.05), and 25-hydroxyvitamin D tended to correlate (r = 0.3016, NS). The study strongly indicates that cutaneous synthesis, intestinal absorption and hepatic hydroxylation of vitamin D are not deficient in scleroderma. A relative but specific decrease in the renal hydroxylation to 1,25-dihydroxyvitamin D, i.e. the active hormone, as the disease progresses and calcinosis occurs, is suspected.
Candidiasis: the isomorphic response
Authors: Witkowski JA , Parish LC.
Published: August 2023

Two uncontrolled insulin dependent diabetic patients had Candida albicans infection with the unique manifestation of erythematous scaling papulopustules at the sites of excoriation. In one patient, the clinical presentation suggested herpes zoster. Recognition of this picture and the contributing factors, i.e. Candida infected finger nails and elevated blood sugar will permit early use of appropriate antifungal therapy.
Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin
Authors: Fjellner B , Hägermark O.
Published: August 2023

Cutaneous pruritic effects of synthetic platelet activating factor (PAF-acether) and, in particular, its interference with dermal mast cells, were studied in human volunteers. Intradermal injections of 10-100 ng produced dose-dependent flare and itching responses. The cutaneous reactions were inhibited by local administration of the H1 antihistamine mepyramin. The cutaneous responses were also markedly reduced in histamine-depleted skin. These findings indicate that the cutaneous responses produced by PAF-acether were mediated via an indirect and mainly histamine-dependent mechanism.
Oxidation of dopa in human albinism
Authors: Carstam R , Hansson C , Krook G , Rorsman H , Rosengren E , Wirestrand LE.
Published: August 2023

The urine of an albino woman contained small quantities of 5-S-cysteinyldopa; 6-hydroxy-5-methoxyindole-2-carboxylic acid, a melanin precursor metabolite, was lacking. The 5-S-cysteinyldopa excretion observed may reflect non-specific oxidation of dopa. Two other albino patients showed normal values for the excretion of 5-S-cysteinyldopa and of 6-hydroxy-5-methoxyindole-2-carboxylic acid.
Urinary excretion of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid: differences between pigmented and albino mice
Authors: Ekelund MC , Carstam R , Hansson C , Rorsman H , Rosengren E.
Published: August 2023

Urinary excretion of the phaeomelanin precursor 5-S-cysteinyldopa (5-S-CD) and the eumelanin metabolite 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI-2-C) was studied in black and albino mice. The urinary concentration of 5-S-CD was 31.7 ng/ml in black and 16.1 ng/ml in albino mice. The concentration of 6H5MI-2-C was 21.0 ng/ml in the urine of black mice. The compound could not be demonstrated in the urine of albino mice.
Coagulation and fibrinolytic systems during the course of erysipelas and necrotizing fasciitis and the effect of heparin
Authors: Hammar H , Sverdrup B , Borglund E , Blombäck M.
Published: August 2023

Necrotizing fasciitis (NF) is a grave infection of the skin leading to gangrene of the integument and often having a complicated and prolonged course. Studies on blood coagulation and fibrinolysis were done in 15 patients with NF and compared with 5 cases of erysipelas (E). In both conditions local fibrin deposition occurred initially in their course, but it was quantitatively more pronounced in NF than in E. Fibrinolysis decreased and stayed low at the site of NF up to 5 months (median) after discharge from hospital. Fibrinogen and activities of several plasma serine proteinases modifying coagulation were increased during the course of both diseases and even at the follow-up. Factor XII was decreased during the first week in E but a transient drop was present in NF only on days 3 and 4. The treatment of NF consists of high doses of appropriate antibiotics instituted early in its course. A beneficial effect of 300-500 IU heparin/kg/day was suggested from this open study. The hard induration preceding the appearance of skin gangrene was inhibited, if heparin was given early in the course of NF. We conclude that the enhanced fibrin deposition and vascular occlusions in the skin are the basis for most complications present in NF.
Epidermolysis bullosa simplex localisata associated with anodontia, hair and nail disorders: a new syndrome
Authors: Gamborg Nielsen P , Sjölund E.
Published: August 2023

Two cases of epidermolysis bullosa simplex localisata associated with anodontia, hair and nail disorders were described. It was proved that the reported cases represented a new syndrome, which had previously not been published. The syndrome was named "Syndroma Kallin" after the surname of the two patients. Two genetic theories were suggested: an autosomal recessive genetic trait or a gonadal mosaicism with an early dominant gene mutation.
Crossed-leg callosities
Authors: Cox NH , Finlay AY.
Published: August 2023

We report five patients in whom localised callosities were found on the dorsum of the feet. This was bilateral in four cases and was due to repetitive minor trauma associated with the sitting posture adopted by the patients. Three of the patients also had psoriasis vulgaris which was clinically dissimilar to the lesions we describe.
Macromelanosomes in X-linked ocular albinism (XLOA)
Authors: Yoshiike T , Manabe M , Hayakawa M , Ogawa H.
Published: August 2023

A case of X-linked ocular albinism is reported. Characteristic Masson-Fontana positive and Dopa positive giant melanin granules were found in keratinocytes, melanocytes and upper dermis. Ultrastructurally the macromelanosome was composed of a dense core and a less dense surrounding mantle.
Diffuse fasciitis with eosinophilia associated with morphea and lichen sclerosus et atrophicus
Authors: Mensing H , Schmidt KU.
Published: August 2023

Diffuse fasciitis with eosinophilia (DFE) is a well described syndrome, among the connective tissue disorders. However, DFE is not commonly accepted as an own entity, because of its rare evolvement in scleroderma and the often indistinguishable histological pattern of both diseases. Here we report on the association of DFE and morphea in two patients and an additional lichen sclerosus in one of them. This points to a close relationship of DFE and other connective tissue diseases.
Radiographic bone surveys after isotretinoin therapy for cystic acne
Authors: Ellis CN , Pennes DR , Martel W , Voorhees JJ.
Published: August 2023

Seven patients underwent retrospective radiographic examination 10 to 16 months after high dose isotretinoin therapy for severe cystic acne. One patient, who received the highest isotretinoin dose (approximately twice the average dose taken by the remaining patients), had multiple small hyperostoses of the thoracic spine and tarsi navicular. These findings were identical to the skeletal changes known to occur during retinoid administration. Prospective studies are needed to ascertain the risk of developing hyperostoses during isotretinoin therapy for acne at the lower doses currently employed. In this preliminary study, clinically significant hyperostoses were not a late sequela of high dose isotretinoin treatment for acne.
Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis
Authors: Turjanmaa K , Salo H , Reunala T.
Published: August 2023

Fifty patients with chronic plaque psoriasis were treated with trioxsalen bath PUVA and 43 patients with oral methoxsalen PUVA. The two treatment regimens gave similar results; 75% and 77% of the patients had excellent or good clearing and a follow-up of one year revealed relapses in 61% and 58% of the patients, respectively. The cumulative UVA dose remained significantly lower in bath PUVA (mean 23.5 J/cm2) than in oral PUVA (mean 131 J/cm2). Nausea and headache occurred in 21% of the patients receiving oral PUVA but in none in the bath PUVA group. Local side-effects were found in 30% of the patients receiving bath PUVA and in 17% of the patients in the oral PUVA group.
Clinical Characteristics of Adults Patients Considered Immunosuppressed in this New Global Immunodeficiency
Authors: WL Huang
Published: August 2023

Introduction: All the things that exist in our universe is composed of energy, including human being. In this article, I will show the most important clinical manifestations presented by patients nowadays, caused by this energy deficiency condition, after the implementation of the modernization of telecommunication. Due to these energy alterations, there is the necessity of using more highly diluted medications in the treatment of the majority of diseases and also there is the necessity to recharge the “battery” of these organs’ energy using Phosphorus, Sulphur, Calcarea carbonica, Silicea, Natrum muriaticum in their daily life according to the theory of Constitutional Homeopathy of the Five Elements Based on Traditional Chinese Medicine, to keep our health in harmony and prevent the formation of the majority of chronic diseases. The use of these five highly diluted medications is of paramount importance to treat the cause of the formation of the majority of emotional and physical symptoms presented by our patients nowadays, independently on the age group or the type of diagnosis and disease that the patient is presenting nowadays.
Iga Associated Lymphocytic Vasculopathy: an Underrecognized Entity
Authors: D Niharika
Published: August 2023

Immunoglobulin A (IgA) associated lymphocytic vasculopathy is an uncommonly reported entity in which IgA immune complexes evoke a lymphocytic vascular reaction instead of a neutrophilic vasculopathy. We present the clinical, histopathological and immunofluorescence features of IgA associated lymphocytic vasculopathy in a 25 year old male
PAPA like Syndrome Associated with Takayasu Arteritis Responding to Corticosteroids: A Case Report
Authors: Dhattarwal Niharika
Published: August 2023

Pyoderma gangrenosum, pyogenic sterile arthritis and acne (PAPA syndrome) is a hereditary, autosomal dominant, auto- inflammatory disease caused by missense mutation in the proline/serine/threonine phosphatase-interacting protein 1 (PSTPIP1) gene and predominantly affecting the joints and skin. Many reports now suggest that the clinical phenotype of PAPA syndrome may vary among people carrying the mutation and can lack the classic triad of pyogenic sterile arthritis, Pyoderma gangrenosum and cystic acne. No definite treatment strategy has been established for this PAPA like syndrome so far. We describe the treatment response of corticosteroids in a 23-year-old male with PAPA like syndrome and Takayasu arteritis, an association which has never been reported before.
A Prospective Prescription Audit of Topical Corticosteroid usage at Skin OPD in a Tertiary Care Centre
Authors: Nair Pragya
Published: August 2023

Introduction: Topical corticosteroids are used for various conditions in dermatology like vitiligo, eczema and psoriasis. They should be used rationally to minimize the side effects. The present study is done to document and improve the pattern of prescribing topical steroids among patients attending Skin OPD at tertiary care centre. Material & Methods: The study was a prospective audit of 100 prescriptions issued to the patients in skin OPD. The data was collected for age and sex of patients, dermatosis for which it is prescribed, number and molecule of drugs, with its dose, site, duration, strength, quantity and frequency of administration. Descriptive statistics was used for analysis. Results: Present study is an audit of 100 prescriptions. Sixty two patients were males and 49% were in 13-40 years of age group. Most common skin condition for which topical steroid prescribed was eczema in 34%. Average 3-6 drugs were prescribed in majority (82%) of prescriptions. The potent corticosteroids was the most frequently prescribed group in 46% prescriptions and most common molecule prescribed was betamethasone valerate in 27%. In 73% prescriptions twice daily application was advised. Maximum 50% prescriptions of TCS were for 7-15 days and site of application was mentioned in 70%. Generic and brand names were mentioned in all prescriptions with quantity of drug. Fingertip unit application was mentioned in 3% of prescriptions. Conclusion: The most common indication for prescribing topical steroids was eczema and the most common molecule prescribed was betamethasone valerate. Generic and brand names for drugs were used in all prescription, but advice about Finger tip method application was not a routine practice.
Pneumocystis Pneumonia after Initiation of Adalimumab in a Patient with Psoriasis and Concomitant Methotrexate-Induced Pancytopenia
Authors: Boswell Nicole D
Published: August 2023

Pneumocystis jiroveci pneumonia (PCP) can be a fatal infection developing in those with and without HIV with an increased mortality in those without HIV. The development of biologics for autoimmune and dermatologic disease has increased the prevalence of patients who are immunocompromised due to medication. Our case presents a 51-year-old HIV negative male with psoriasis and psoriatic arthritis who developed PCP after initiating adalimumab. He had previously been taking methotrexate as monotherapy with inadequate control of symptoms. PCP can present with or without respiratory symptoms in those who are immunocompetent, which may cause unintentional shedding to those who are immunocompromised. Due to the detrimental effects of the infection, it is important for dermatologists to be aware of this potential risk of PCP with biologics and considerations for screening for PCP prior to initiating biologic therapy
Vaginal Atrophy Vectors Technique – A Technique for Safe, Simple and Effective Vaginal Injection of Hyaluronic Acid
Authors: VC Amaral
Published: August 2023

The injectable use of hyaluronic acid in the vaginal walls has demonstrated encouraging results in improving the symptoms of vaginal atrophy. The therapy has not yet settled, however, due to reports of associated non-thrombotic pulmonar embolism, in which an overdose of hyaluronic acid was injected into the deep layer of the anterior vaginal wall, an area of high vascular risk, by non-physicians. We have used a simple and safer technique since 2019, whereby only 1ml of hyaluronic acid is injected superficially, in the submucosal plane, through a blunt-tipped cannula, in the posterior wall, with excellent results and fewer complications
Pulmonary Mucormycosis: A Case Report
Authors: Alnoury Mostafa
Published: August 2023

Mucormycosis an opportunistic mycosis, has emerged as a significant concern among severely immune compromised individuals, particularly those with hematologic malignancies or those who have undergone stem cell or organ transplantation. In this case report, we present a rare case of pulmonary mucormycosis complicated by abscess formation in a middle-aged male with a medical history of Acute Myeloid Leukemia (AML). The imaging findings revealed a non-specific fungal infection, and the pathology report confirmed the diagnosis of pulmonary mucormycosis. Subsequently, the patient underwent a successful left upper lobectomy and is currently in a stable condition.
Beyond the Tag: A Parent Training Experience in the Healthcare Field
Authors: M Vaccaro
Published: August 2023

Behavioral difficulties related to internalizing neurodevelopmental disorders represent one of the main areas of work in clinical practice within pediatric services (Steiner & Remsing, 2007). From 2013 to 2023, there has been an increase in triage visits for behavioral difficulties in the ASL TO3, from 6 to 40 cases per year. Data from the company database show increasing diagnosis of Oppositional Defiant Disorder-ODD, Attention Deficit Hyperactivity Disorder-ADHD, and Conduct Disorder-CD in recent years. Therefore, the Pediatric Psychology SSC Service of TO3 decided to work indirectly on the management of dysfunctional behaviors and emotional self-regulation of children aged 3 to 11 years, by activating Parent Training groups oriented to ACT for parents of children who come to triage with symptoms that suggest the presence of ADHD, ODD, or CD, or having a diagnosis themselves. The goal of the intervention was to reduce parental stress, frustration and feeling of loneliness, hyperactivity and compositionality of the children involved, as well as internalizing difficulties and increasing caregiver awareness of possible appropriate educational strategies. The activation of the Parent Training pilot project within an outpatient pathway of the National Health Service has allowed a wide range of the population to be reached, optimizing resources and time to meet the parents’ needs. The results obtained before and after the Parent Training intervention prove its effectiveness.
The Importance and Awareness Level of Ergonomics in Terms of Office Workers
Authors: K Erol
Published: August 2023

Ergonomics is a branch of science that aims to examine the behavioral and biological characteristics of human beings and to create suitable living and working environments. The main goal of ergonomics, which is especially important for office workers, is to improve the quality of business life and working environments. From this point of view, the importance of ergonomics emerges in different health problems ranging from musculoskeletal problems to psychological disorders. As a reflection of these reasons, within this study’s scope, a survey was conducted on the office workers working in institution A. While questions about personal information are asked in the first part of the survey, there are detailed questions about ergonomics in the second part. The results were very interesting and supported by an additional survey conducted with the office workers of institution B. As a result of the evaluation, it was seen that the knowledge and awareness levels of the office workers about the science of ergonomics were not at the desired level. However, it has been determined that the awareness of the science of ergonomics can be increased with appropriate training, and thus, the health problems arising from ergonomics can be minimized.
The Relationship between Job Stress and Musculoskeletal Disorders among Midwives
Authors: M Mohammadian
Published: August 2023

Job stresses can increase the prevalence of musculoskeletal disorders (MSDs) in midwifery job, and reduce the efficiency and quality of their services. Therefore, this study was conducted to determine the prevalence of MSDs among midwives and to examine the relationship between job stress and the prevalence of MSDs in different regions their body. This was descriptiveanalytical and cross-sectional study. The study population included all midwives working in public and private hospitals of Kerman in 2019. According to the research community, 74 midwives were selected as a sample of research, by Census method. For data collection, Standard Nordic Musculoskeletal Questionnaire (NMQ) and Altmeyer job stress questionnaire were used. The data were analyzed with descriptive and analytical statistics (Pearson correlation, t-test and Chi square test) methods by SPSS 16 software. In this study 78.4 % of subjects had experienced discomfort or pain in the past 12 months at least in one body part. The most frequent symptoms of MSDs were observed in the three parts of body, feet with a frequency of 39.2% (29 persons), and knees and back each one 35.1% (26 persons). Also in this study, the relationship between musculoskeletal disorders and job stress was dignificant (P<0.05). According to the result of this research, it can be concluded that job stresses can presumably intensify physical side effects including musculoskeletal disorders. Also, the prevalence of musculoskeletal disorders in midwives under studied was high. Therefore, holding training courses about standard body postures while doing job tasks and avoiding inappropriate body posture will be important.
ADAS: Should we be too Reliant for Driver Safety?
Authors: R Biswas
Published: August 2023

Advanced driver assistance systems has come a long way since its inception. It has evolved many folds and has now entered many mid-range vehicles. This article appraises certain features of ADAS as well as its’ pros and cons. Emphasizing the vital parts of this system, this article also highlights the challenges ahead and way forward.
Application of Construct on Scaffold Concept Map in Mobile Programming Learning with Flutter Layout Topic
Authors: Putra Prima Arhandi  , Annisa Taufika Firdausi  , Vivin Ayu Lestari  , Abdurrasyid Muhasibi  , Dharma Yudistira Eka Putra  , Banni Satria Andoko
Published: August 2023

Flutter is a framework for making mobile applications cross-platform made by Google. From 2019 to 2021 the popularity of flutter is increasing. Flutter use declarative writing style to create layouts. This makes the layout in flutter immutable, and a light blueprint. This research proposes a construct on scaffold concept map method to help students understand the concept of widget arrangement in flutter layout. Construct on scaffold will provide the learner with a framework from an incomplete expert concept map. Some of the nodes and connecting relationships in the framework have been removed, so students must fill in the missing parts with several available answer choices to complete the concept map. To prove the impact of the application of this method, the study was conducted using a pre-post-test group experimental design. Students will do a pre-test, use the EasyFlutter application, and post-test. The results of the pre-test and post-test obtained were tested for normality first, then tested to find out whether there was an average difference between the pre-test and post-test scores. The results of the normality test show that the pre-test data are not normally distributed, and the post-test data are normally distributed, so the next test will use a non-parametric test, namely the Wilcoxon test. The test results show that the post-test mean score is higher than the pre-test mean. Wilcoxon test results also show that the Asymp value. Sig. (2-tailed) of 0.01, so it can be concluded that there is a significant difference between the pre-test and post-test scores. The application of the construct on scaffold method has a significant positive impact on the post-test scores of students related to the concept of widget arrangement in flutter.
Electronic Procurement Website Service Quality and Customer Loyalty Using The Pieces Method, A Case Study of The Denpasar City Government
Authors: IG Wahyu Sanjaya
Published: August 2023

The Denpasar city government uses website facilities to display information on the procurement of goods and services. Publication of information through the website is intended to create a transparent, effective, efficient and accountable procurement system. From it’s initial use since 2013, this system has never been tested to determine whether the system is still in good condition. This study aims to evaluate the system based on user loyalty using the PIECES method. So that the website manager gets input about the quality of the website from the user's point of view. The results of the tests that have been carried out in this study indicate that the Performance Indicators scored 4.2 in the Very Satisfied category, the Information Indicators obtained a value of 4.2 in the Very Satisfied category, Economic Indicators obtained a value of 4.1 in the Satisfied category, Control and Security Indicators obtained a value of 4.3 in the Very Satisfied category, the Efficiency indicator got a score of 4.3 in the Very Satisfied category, the Service indicator got a score of 4.2 in the Very Satisfied category.
Applying Use Case 2.0 Approach to The Development of IoT-Based Rainfall Monitoring System
Authors: Fajar Mohammad , Chandra Ferian Bagus , Arfandy Hamdan
Published: August 2023

The use of Internet of Things (IoT) technology for monitoring and controlling environmental conditions or objects is quite popular. However, most of the development of the IoT systems including rainfall monitoring systems, mainly focuses on the implementation perspective, rather than discussing the development approaches or design techniques. The use of suitable development approaches will increase maintainability aspect of the IoT system in the future. Therefore, the aim of this study is to implement and evaluate the use case 2.0 approach in modeling and designing an IoT-based monitoring rainfall system. Data collection was performed through evaluation using object-oriented metrics to measure encapsulation, polymorphism, and reusability properties of the designed system. In modeling the IoT system, collected requirements specifications are organized into user stories. The user stories are then mapped into UML use case diagrams. Each of the use case should be sliced into thinner pieces, taking into account of the basic and alternative flows of the user stories. Moreover, the use case slices are designed, implemented, and evaluated independently. The results of modeling and designing a rainfall monitoring system using the use-case 2.0 are then implemented on the NodeMCU platform and Android-based application. Evaluation results show that the implementation of use-case Reading, Viewing and Searching for Rainfall Data can be run successfully on the target platform.  The measurement uses object-oriented metrics on the designed IoT system indicating that the use case slices have an impact on the ease of system modification level.