bluuebunny/crossref_metadata_2025 huggingface dataset:
Pentingnya Menjaga Imunitas Bagi Lansia di Masa Pandemi Covid 19
Authors: Sakitri Ganik , Astuti Ratna Kusuma
Published: December 2021

ABSTRAK Covid-19 adalah virus baru penyebab penyakit saluran pernafasan. Untuk mendukung program pemerintah dalam upaya memutus rantai penularan Covid-19 perlu partisipasi dan dukungan dari masyarakat. Menjaga imunitas sangat penting terutama ditengah pandemi Covid-19. Tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan pendidikan kesehatan kepada masyarakat dalam pencegahan covid 19. Upaya promosi kesehatan ini dapat dilakukan dengan menggunakan berbagai metode dan media yang dapat disesuaikan dengan sasaran. Cara efektif dalam pendekatan kelopok adalah dengan metode ceramah dan alat bantu yaitu leaflet. Terdapat peningkatan pengetahuan lansia tentang covid 19 di desa Kedungan, Pedan, Klaten. Kata kunci: Lansia, imunitas, covid 19  ABSTRACT Covid-19 is a new virus that causes respiratory disease. To support government programs in an effort to break the chain of transmission of Covid-19 needs the participation and support of the community. Maintaining immunity is very important, especially in the midst of the Covid-19 pandemic. The purpose of this community service activity is to provide health education to the community in preventing COVID-19. This health promotion effort can be done using various methods and media that can be adapted to the target. The effective way in the group approach is the lecture method and assistive tools, namely leaflets. There is an increase in the knowledge of the elderly about covid 19 in the village of Kedungan, Pedan, Klaten. Keywords: Elderly, immunity, covid 19
Peningkatan Pengetahuan Terkait Vaksinasi Covid-19 Di Panti Asuhan Raudatul Aitam Bandar Lampung
Authors: Yulendasari Rika , Rahayu Rahayu
Published: December 2021

ABSTRAKBerawal dari munculnya kasus pneumonia di Wuhan, China yang belum diketahui penyebabnya. Kasus ini terjadi pada akhir tahun 2019, tepatnya pada bulan Desember. Menurut hasil epidemiologi, kasus pneumonia yang terjadi terkait dengan pasar ikan di wilayah Wuhan. WHO menetapkan penyakit ini diberi nama Coronavirus disease 2019 atau bisa juga disebut COVID-19. Tujuan setelah penyuluhan kesehatan adalah untuk menambah pengetahuan terkait vaksinasi COVID-19 dan partisipan penyuluhan dapat mengikuti program vaksinasi yang diselenggarakan oleh pemerintah. Ada juga kegiatan yang dicoba berupa penyuluhan kesehatan dengan menggunakan flip chart dan leaflet. Terjadi peningkatan pengetahuan hingga 80% terkait vaksinasi COVID-19 pada partisipan penyuluhan di panti asuhan Raudatul Aitam.Kata kunci: Pengetahuan; Vaksinasi; COVID-19; Panti Asuhan Anak ABSTRACTStarting from the emergence of cases of pneumonia in Wuhan, China whose cause is not yet known. This case occurred at the end of 2019, precisely in December. According to epidemiological results, the pneumonia cases that occurred were related to a fish market in the Wuhan area. WHO has determined this disease to be named Coronavirus disease 2019 or it can also be called COVID-19. The goal after health education is to increase knowledge regarding COVID-19 vaccination and counseling participants can take part in vaccination programs organized by the government. There are also activities that are tried in the form of health education using flip charts and leaflets. There was an increase in knowledge of up to 80% related to COVID-19 vaccination among counseling participants at the Raudatul Aitam orphanage. Keywords: Knowledge; Vaccinations; COVID-19; Children's Orphanage
Sistem Kartu Ujian Online Menggunakan Framework Yii Pada Universitas Raharja
Authors: Immaniar Dewi , Cholisoh Novi , Eka Putra Fajar Januar , Pangestu Prisilia Santoro
Published: December 2021

Proses pembuatan kartu ujian setiap pergantian semester adalah mengkombinasikan beberapa komponen yang terdiri atas mahasiswa, dosen, ruangan, waktu dan pembayaran. Pembuatan kartu ujian membutuhkan waktu, tenaga dan ketelitian dalam membuatnya dan juga proses yang sangat lama yaitu sekitar satu mingguan karena masih bersifat manual alias jadul , untuk dapat menghasilkan kartu ujian pihak dari RPU harus membuat jadwal ujian dulu yang datanya diambil dari data OJRS+ . Penelitian ini membuat perancangan kartu ujian online menggunakan YII Framework. Hal ini dapat menjadi permasalahan karena masih dimungkinkan adanya resiko permasalahan bentrok. Semua permasalahan ini dapat diselesaikan dengan sebuah sistem yang dapat membuat jadwal secara otomatis atau secara online.Dengan ini akan membicarakan bagaimana membangun sebuah aplikasi penjadwalan otomatis mulai dari analisa kebutuhan hingga bagaimana sebuah permasalah penjadwalan dapat diselesaikan.

Kata Kunci: Optimalisasi, online, Kartu Ujian, framework bootstrap
Effect of metal content from sewage sludge on the growth of Orthosiphon stamineus
Authors: Zaidi Nur Syamimi , Sohaili Johan , Loh Zhang Zhan , Arisa Azmi , Hussein Norelyza
Published: December 2021

Municipal sewage sludge can be used as fertilizer as it contains a lot of nutrients. By focusing on copper (Cu), iron (Fe), manganese (Mn), and zinc (Zn) contents in municipal sewage sludge from primary oxidation ponds and in plant tissue sections, this study attempts to explain the relationship between plant yield and metal concentrations. Raw sludge samples were collected, air-dried, and ground to powder form at the beginning of fieldwork. The metal concentrations of sewage sludge were copper 6.9 mg/kg; iron 330.2 mg/kg manganese 6.7 mg/kg and zinc 9.1 mg/kg. Orthosiphon stamineus (cat’s whiskers) was selected and the plant received a different quantity of sludge application ranging from 1 g to 4 g per plant weekly for six consecutive weeks while observations were done for eleven weeks. Physical parameters such as shrub width and height were monitored to determine plant growth. Through this study, the determined optimum sewage sludge dosage for cats’ whiskers was between 2 to 3 g per plant.
Study on household waste management in Kampung Parit Haji Siraj, Johor, Malaysia
Authors: Nazira Binti Azahar Nazatul , Zuhaili Bin Mohamed Najib Mohamed , Fikri Bin Basri Hazlami , Noor Hazwan Jusoh Muhammad , Noor Hasanah Binti Tuan Ismail Tuan
Published: December 2021

Waste management issue has been a major threat and challenge due to the undergoing rapid industrialization and urbanization not only to Malaysia, but also other countries around the world. To tackle that, the first step starts at household level where people are encouraged to try to manage their wastes properly. The aim of this study was to review the current practises of household waste management, to assess household awareness of the health and safety risked posed by inadequate handling of special household waste and to identify future prospect and potential for effective waste management system in Kampung Parit Haji Siraj, Ayer Hitam, Johor. A survey questionnaire was used to collect complete information on the objectives stated and the data were analysed using SPSS software. Results showed that 97.2% of residents were aware about waste management and social media with 80% contributed the most in delivering information about waste management to the public. The most type of solid waste generated from household were food waste and plastic with 94.4% and 86.1%, respectively. 66.7% of residents emptied their waste container once in 2 days and about 63.9% of the residents dispose their household waste in a hole near their compound. Majority of the residents are aware of any health and safety risked posed by inadequate handling of household waste. Lastly, waste management system in the area can be improved by providing proper waste disposal place and educating proper disposal ways to guarantee that residents do not discard their waste in an indiscriminate manner.
Hubungan Stres Kerja, Umur, dan Perilaku Merokok dengan Tekanan Darah Pada Pekerja Di PT. Industri Kapal Indonesia (PERSERO) Kota Makassar
Authors: Basruddin Saskia , Fachrin Suharni A. , Patimah Sitti
Published: December 2021

Pekerja bagian produksi adalah salah satu pekerja yang mempunyai resiko terkena tekanan darah tinggi maupun tekanan darah rendah yang sering dijumpai dalam masyarakat. Tekanan darah tinggi dapat disebabkan oleh berbagai macam faktor, salah satunya adalah stres. Stres merupakan suatu respon nonspesifik dari tubuh terhadap setiap tekanan atau tuntutan yang mungkin muncul, baik dari kondisi yang menyenangkan maupun tidak menyenangkan. Penelitian ini bertujuan untuk Mengetahui Hubungan Antara Stress Kerja, Umur Dan Perilaku Merokok Dengan Tekanan Darah pada Pekerja Di PT.Industri Kapal Indonesia (Persero) Makassar  Tahun 2020 dengan menggunakan metode observasional analitik dengan pendekatan cross sectional study. Hasil ini menunjukkan terdapat hubungan signifikan antara stres kerja dengan tekanan darah (0,003<0,005), (0,205<0,005) tidak ada hubungan signifikan antara umur dengan tekanan darah (0,863>0,005) tidak ada hubungan signifikan antara perilaku merokok dengan tekanan darah.
Hubungan Faktor Sosial Ekonomi dan Riwayat Pemberian ASI Eksklusif dengan Kejadian Stunting pada Balita
Authors: Pertiwi Fenti Dewi , Prastia Tika Noor , Nasution Andreanda
Published: December 2021

Stunting pada Balita merupakan indikator dari kesejahteraan dan ketidaksetaraan sosial. Stunting lebih banyak dialami oleh anak dari keluarga dengan sosial ekonomi rendah. Puskesmas Bantargadung Kabupaten Sukabumi membawahi 6 Desa termasuk dalam 1000 Desa prioritas percepatan penurunan Stunting. Faktor lain yang mempengaruhi kejadian Stunting pada Balita diantaranya pemberian ASI eksklusif dan pengenalan MP-ASI dini.  Jumlah Balita prevalensi Stunting 2.4% (82 Balita). Penelitian ini bertujuan menganalisis hubungan faktor sosial ekonomi dan riwayat pemberaian ASI Eksklusif dengan Stunting pada Balita di Kecamatan Bantargadung. Penelitian dilaksanakan bulan Mei-Agustus 2020. Hasil penelitian menunjukkan bahwa faktor sosial ekonomi, yaitu kepemilikan rumah (Pv=0,036) dan kepemilikan jaminan kesehatan (Pv=0,000) berhubungan signifikan dengan Stunting pada Balita, adapun pendidikan Ibu (Pv=0,299), pendidikan Ayah (Pv=0,234), pekerjaan Ibu (Pv=0,535), pekerjaan ayah (Pv=0,492), jumlah tanggungan (Pv=0,111) dan pendapatan (Pv=0,319) tidak berhubungan signifikan dengan Stunting pada Balita. Riwayat pemberian ASI Eksklusif, yaitu pemberian ASI Eksklusif (Pv=0,736), umur pemberian MP ASI (Pv=0,717) dan Pemberian kolostrum (Pv=0,099) tidak berhubungan signifikan dengan Stunting pada Balita.
Gambaran Konsumsi Gula, Garam dan Lemak (Minyak) pada Anak Sekolah
Authors: Rembet Tesalonika Gisela , Nugroho Kristiawan Prasetyo Agung , Mangalik Gelora
Published: December 2021

Anak usia sekolah (6-12 tahun) merupakan kelompok usia dengan tumbuh kembang pesat kedua setelah masa Balita. Perhatian orangtua dan keluarga penting dalam pemilihan makanan. Penelitian ini bertujuan untuk mengetahui gambaran konsumsi garam, gula, dan lemak (minyak) siswa di beberapa sekolah dasar di Kecamatan Tondano Utara, Kabupaten Minahasa. Jenis penelitian adalah deskriptif kuantitatif dengan teknik pengambilan data purposive sampling. Data dianalisa secara deskriptif dalam bentuk tabel dan grafik. Penelitian dilakukan pada bulan Mei 2020. Responden penelitian sebanyak 60 siswa kelas I-IV dari SD GMIM Wulauan, SD GMIM Tonsea Lama, dan SD Inpres Marawas. Pengambilan data menggunakan kuesioner untuk mengetahui faktor-faktor yang mempengaruhi perilaku makan responden, SQ-FFQ (data kebiasaan makan), Food Recall 2x24 jam (data asupan makan), serta pengukuran antropometri. Hasil Food Recall 2x24 jam didapatkan bahwa gambaran konsumsi asupan garam sebanyak 432,02 mg, asupan gula sebanyak 0,02 g, dan asupan minyak (lemak) 32,23 g, berada pada kategori kurang. Konsumsi Gula, Garam, dan Lemak (minyak) (GGL) responden termasuk kurang. Asupan GGL tetap perlu dijaga agar tidak melebihi batas konsumsinya dengan membatasi jajanan yang manis, gurih, dan berlemak serta memberikan pendidikan gizi kepada anak tentang makanan dan jajanan yang sehat.
Hubungan Pengetahuan dan Pendidikan dengan Partisipasi Kader dalam Kelas Ibu Hamil
Authors: Nurhidayah Nurhidayah , Yuanti Yocki
Published: December 2021

Kelas ibu hamil merupakan sarana belajar bersama tentang kesehatan untuk  ibu hamil dalam bentuk tatap muka. Tahapan penting dalam kelas ibu hamil  adalah sosialisasi, dimana  kader sangat berperan dalam sosialisasi tersebut sebagai salah satu elemen penting dalam masyarakat. Indikator penilaian kelas ibu hamil salah satunya adalah persentase partisipasi kader. Penelitian ini bertujuan untuk mengetahui  hubungan  pengetahuan dan pendidikan dengan partisipasi kader dalam kelas ibu hamil. Metode yang digunakan adalah analitik kuantitatif dengan desain cross sectional. Populasi penelitian adalah seluruh kader di Puskesmas Harjamukti sebanyak 160 orang dengan sampel 128 orang, yang dihitung mengunakan rumus Slovin. Data dianalisis mengunakan uji Chi Square. Hasil penelitian didapatkan bahwa ada hubungan yang bermakna antara pengetahuan (Pv=0,000; OR=14,375) dan pendidikan (Pv=0,000; OR=11,357) partisipasi kader dalam kelas ibu  hamil. Disarankan pada  tenaga kesehatan khusunya bidan untuk aktif melaksanakan sosialisasi kelas ibu hamil pada kader.
The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements
Authors: Grasedieck Sarah , Cabantog Ariene , MacPhee Liam , Im Junbum , Ruess Christoph , Demir Burcu , Sperb Nadine , Rücker Frank G. , Döhner Konstanze , Herold Tobias , Pollack Jonathan R. , Bullinger Lars , Rouhi Arefeh , Kuchenbauer Florian
Published: December 2021

Aberrant expression of Ecotropic Viral Integration Site 1 (EVI1) is a hallmark of acute myeloid leukemia (AML) with inv(3) or t(3;3), which is a disease subtype with especially poor outcome. In studying transcriptomes from AML patients with chromosome 3q rearrangements, we identified a significant upregulation of the Nuclear Receptor Interacting Protein 1 (NRIP1) as well as its adjacent non-coding RNA LOC101927745. Utilizing transcriptomic and epigenomic data from over 900 primary samples from patients as well as genetic and transcriptional engineering approaches, we have identified several mechanisms that can lead to upregulation of NRIP1 in AML. We hypothesize that the LOC101927745 transcription start site harbors a context-dependent enhancer that is bound by EVI1, causing upregulation of NRIP1 in AML with chromosome 3 abnormalities. Furthermore, we showed that NRIP1 knockdown negatively affects the proliferation and survival of 3qrearranged AML cells and increases their sensitivity to all-trans retinoic acid, suggesting that NRIP1 is relevant for the pathogenesis of inv(3)/t(3;3) AML and could serve as a novel therapeutic target in myeloid malignancies with 3q abnormalities.
СТАТУС ОРГАНІВ МІСЦЕВОГО САМОВРЯДУВАННЯ НА ОКРЕМИХ ТЕРИТОРІЯХ УКРАЇНИ
Authors: Зелинська Наталя
Published: December 2021

Досліджено використання комплексного механізму військово-цивільної адміністрації, відносини між рівнями управління на окремих територіях України. Розглянуто, як цей приклад покращує або змінює розуміння статусу органів місцевого самоврядування в особливих умовах. На цій основі проведена оцінка того, чи дійсно військово-цивільні адміністрації забезпечують закріплене право територіальних громад на місцеве самоврядування. Проаналізовано проблематику поточної взаємодії при здійсненні повноважень всіх державних органів на територіях з особовим статусом. Надано науково обґрунтовану інформацію про характер проблем у процесі управління обласними радами на територіях, на яких функціонують військово-цивільні адміністрації Донецької та Луганської областей, пропозиції щодо пріоритетних напрямів їх розв’язання та  шляхи оптимізації системи управління в області функціонування військово-цивільних адміністрацій. Якісне функціонування військово-цивільних адміністрацій як резервного механізму державного управління та забезпечення виконання законів України має вирішити загострену проблематику законодавчого врегулювання діяльності органів місцевого самоврядування у Донецькій та Луганській областях. Правовому урегулюванню підлягають відносини у сфері праці, оплати трудової функції, підпорядкуванні працівників правилам трудового розпорядку, передбачених трудовим законодавством та іншими нормативно–правовими актами з трудового права, колективним договором, угодами, локальними нормативними актами, трудовим договором тощо. Недосконалість положень Закону України «Про військово-цивільні адміністрації», пов’язується з необхідністю врегулювання питання діяльності органів місцевого самоврядування, неспроможних виконувати свої функції там, де виникла потреба створення нових механізмів управління, таких як військово-цивільна адміністрація. Водночас в Донецькій і Луганській областях, окрім функцій та повноважень встановлених законодавством, в процесі децентралізації вони більше набувають ознак органу місцевого самоврядування та стають механізмом децентралізації на цих територіях. На військово-цивільні адміністрації покладається додаткова функція формування громад, формування нової територіальної основи для функціонування органів місцевого самоврядування. Зазначене актуалізує потребу в дослідженні, метою якого є ідентифікація викликів для органів місцевого самоврядування в межах виконання повноважень військово-цивільними адміністраціями. Визначення реального стану та актуальних проблем у процесі управління обласними радами на територіях утворення цих деожавних органів, проведення аналізу причин їх виникнення, відпрацювання основних напрямів, шляхів та способів оптимізації системи управління та функціонування військово-цивільних адміністрації можуть бути підставою для постановки та проведення інших наукових робіт щодо практичного розв’язання визначених у цій роботи проблем.
Program Revitalisasi Eduwisata Lokalisasi Dolly pada Humas Pemerintah Kota Surabaya
Authors:   Universitas Bhayangkara Surabaya Indonesia, Roosinda Fitria Widiyani , Rachman Noviar Renindia ,   Universitas Bhayangkara Surabaya Indonesia
Published: December 2021

This research’s tittle of Revitalization Program Of The Dolly Localization Tour Public Relations Surabaya City Goverment. Surabaya City Goverment Public Relations closed the prostitution activity in Dolly localizations by used the revitalization program. The program was carried out by the Surabaya Goverment by officially closing Dolly’s localization on June 18, 2014 and maked the former localization a eduwisata village and empowering local residents. This have done to help their economy after each individual after they get moved to another job. And the establishment of the eduwisata village and several child-friendly public facilities. The purpose of this research is to find out what are the steps taken by the Surabaya City Goverment Public Relations in their success in conduction the revitalization program. This research uses a descriptive qualitative research approach,. researcher used the direct interview method to the Surabaya City Goverment Public Relations as the main resource. After that, the researcher concluded what was done by the Surabaya City Goverment, especially the public relations agencies, along with the result they obtained. Dont forget also the various obstacles that occur when the revitalization program takes place.
Studi Netnografi Pola Komunikasi Jaringan Komunitas Cryptocurrency Dogecoin Pada Twitter
Authors:   Program Studi Ilmu Komunikasi Universitas Kristen Petra Indonesia, Tjahyana Lady Joanne
Published: December 2021

Cryptocurrency Dogecoin awalnya dianggap sebagai meme coin namun telah mengalami kenaikan nilai tukar sebanyak 800% pada Januari 2021 dan bertambah lagi sebesar 400% pada April 2021. Hal ini tidak lepas dari dukungan kuat dari komunitas cryptocurrency Dogecoin dan top public profiles pada media sosial Twitter. Penelitian ini menggunakan metode digital netnography untuk melihat pola komunikasi jaringan komunitas cryptocurrency Dogecoin di Twitter. Komunitas yang diteliti tidak terpusat pada akun komunitas tertentu namun meliputi seluruh akun Twitter yang aktif berdiskusi mengenai Dogecoin. Batasan penelitan adalah pada tanggal 1 April - 9 Mei 2021 bertepatan dengan beberapa peristiwa penting yang terjadi. Data yang digunakan adalah semua percakapan pada Twitter dengan kata kunci "Doge" dan diambil menggunakan social network analysis tools Brand24 dan Netlytic. Penelitian ini menemukan adanya 5 tipe interaksi yang merupakan pola komunikasi jaringan Dogecoin. Pola komunikasi yang ditemukan pada penelitian ini dapat memberikan masukan bagi pengembang Dogecoin dan cryptocurrency lainnya tentang pentingnya memberikan informasi yang dapat meyakinkan komunitas untuk tetap hold sebuah cryptocurrency. Kemudian pentingnya membina komunitas yang saling mendukung dan memberi semangat di antara anggota komunitas, dan pentingnya bekerjasama dengan top public profiles untuk memberikan keyakinan dan konfirmasi untuk mengatasi keresahan komunitas terkait volatility yang tinggi dari sebuah cryptocurrency.
A SURVEY ON AUTOMATIC ATTENDANCE SYSTEM ALONG WITH TEMPERATURE USING IOT
Authors: M Rohini , K Meganathan , S Kamali , Shankar S Yuvan , M Nitheesh , N R Deepa
Published: December 2021

Automatic attendance methods are
very helpful for students and workers in order to
make use of their time more effectively.
Maintaining attendance is the most troublesome
assignment in different organizations. In recent
days we have seen abrupt increment in the
utilization of biometric technology in the fields of
IT, education institute, transportation, etc.
Internet of things is also blooming parallel.
Automatic attendance system is an
implementation of internet of things through
Arduino ide, thingspeak finger print scanner
R305 in order to reduce the time consumed by the
traditional attendance method. There are various
technologies like RFID, fingerprint and face
recognition technologies are introduced in order
to save time and reduce efforts. In this paper we
are going to compare those technologies and
understand which is best among them.
ESTIMATION OF COST AND TIME OVERRUN USING NAVFAC P-405
Authors: Sadashiv Patil Nikita , Thorbole Amol
Published: December 2021

— In construction industry delays and cost
overrun are significant problems so it requires
investigation at planning stage. This paper gives
introduction to the NAVFAC P-405, US Naval handbook
for planning and estimation. This is used for site
independent duration calculation and also involves steps
on using NAVFAC P-405 in calculating delays. Further a
method to calculate cost and time overrun for single
activity using NAVFAC P-405 is explained in detail with
case study.
NUTRITIONAL DEFICIENCIES: A REVIEW
Authors: s kumar Aleena
Published: December 2021

Nutrients like proteins, vitamins, minerals,
carbohydrates and lipids are required for the right
function of our body. Nutritional deficiency disorders are
a major problem faced by the world, millions of people in
the world suffer from undernourishment. Deficiency
occurs when the food we are consuming does not contain
the required amount of nutrients or when our body is not
being able to absorb nutrients due to some genetic
disorders or other secondary reasons. Nutritional
deficiency is considered as the ‘hidden hunger’ and a
person can suffer from deficiency of vitamins, proteins,
minerals, carbohydrates and fatty acids. This review
describes the different types of nutritional deficiencies,
their causes, symptoms, treatment and prevention. The
deficiencies are mostly asymptomatic but in a long time
can very adversely affect the body functions and impair
the immune system and cause chronic illness and
infections. The severity of symptoms and the treatment
varies from person to person. Poverty and low health
literacy are the most important reasons for the prevalence
of nutritional deficiencies in the world. However, these
deficiencies can be prevented by promoting health
education among adults, encouraging a healthy and active
lifestyle and providing nutritional and healthy food to the
ones who do not have access to it. Nutrition campaigns,
supplementation and genetic engineering of plants and
food crops has decreased the pervasiveness of deficiency
disorders.
A RESEARCH PROPOSAL FOR THE PROJECT OF IMPLEMENTING ECG TRACKING SENSOR ALARMS IN STREET LIGHT USING SUSTAINABLY PRODUCED ELECTRICITY
Authors: Rana Anshika
Published: December 2021

The main focus of implementing ECG tracking
sensor alarms in street lights using sustainably produced
light is to mainframe the idea of using ecofriendly ways to
produce electricity as well as enhancing the road security.
The idea is to motivate people to enhance physical activities
of all ages and using their work force to produce electric
power which eventually will contribute to better AI-assisted
pedestrian safety system.
EQUAL AND EMPOWERED BY THE CREATOR
Authors: Dhiman Pankhuri , Tyagi Pritanjali
Published: December 2021

Glass ceilinfg effect as defined by the oxford
dictionary Glass ceiling to be an unacknowledged barrier
that prevents minorities or women from advancing in their
profession. And this research article very explains how we
all were created equal and powered by the god, the creator
and it is us who have created several barriers for our fellow
humans living in the world created by the god.
A COMPREHENSIVE REVIEW ON THE USE OF BACTERIOPHAGE IN MICROBIAL KILLING AND CANCER THERAPY
Authors: Sharma Rhea
Published: December 2021

As the name infers, bacteriophage is a
bacterium-explicit infection. It taints and kills the
bacterial host. Bacteriophages have acquired
consideration as elective antimicrobial elements in the
science local area in the western world since the
disturbing ascent of anti-infection obstruction among
organisms. Although considered as prokaryote-explicit
infections, ongoing examinations demonstrate that
bacteriophages can associate with eukaryotic life forms,
including people. In the current audit, these
collaborations are isolated into two classifications, i.e.,
backhanded, and direct connections, with the inclusion of
bacteriophages, microscopic organisms, and eukaryotes.
Conversation on bacteriophage-related illnesses,
transcytosis of bacteriophages, bacteriophage connections
with cancer cells, cooperation of bacteriophages and
eukaryotes against bacterial contaminations, and level
quality exchange among bacteriophages and eukaryotes.
Conversation on the historical backdrop of bacteriophage
revelation and the early clinical investigations with
phages and audit the new writing accentuating research
led in Poland and the previous Soviet Union.
Additionally, conversation on the reasons that the clinical
utilization of bacteriophages neglected to flourish in the
West, and we share our contemplations about future
possibilities for phage treatment research.
The Role of Confocal Endomicroscopy in the Diagnosis and Management of Pancreatic Cysts
Authors: Keane Margaret G , Pereira Stephen P
Published: December 2021

Pancreatic cystic lesions are an increasingly common clinical finding. Current diagnostic techniques cannot reliably differentiate patients with high-risk lesions requiring surgical resection from those that can be safely surveyed or discharged. As a result, some patients may undergo unnecessary surgery with associated morbidity while others enter long-term surveillance with associated healthcare costs. Needle-based confocal laser endomicroscopy enables real time microscopic examination of the epithelial lining of a cyst wall at the time of a standard endoscopic ultrasound examination. The procedure is associated with low rates of adverse events, especially when the probe is loaded into the fine-needle aspiration needle before the procedure and examination times are limited. Needle-based confocal laser endomicroscopy has consistently been shown to have better diagnostic accuracy than cytology, which is often paucicellular and non-diagnostic in pancreatic cystic lesions. Studies have shown that diagnostic accuracy in needle-based confocal laser endomicroscopy is 84–95% in mucinous lesions and 39–99% in serous lesions. However, this technology is expensive and its place in diagnostic algorithms remains uncertain. Despite this, health economic analyses in certain health systems have been favourable, largely because of its potential to be able to discharge patients with benign lesions, such as serous cystic neoplasms, from long-term surveillance. Widespread adoption of this technology is unlikely but it has the potential to have an important role in indeterminate pancreatic cystic lesions.
New Therapeutic Approaches for Acute Myeloid Leukaemia
Authors: Risueno Ruth M , Cuesta-Casanovas Laia , Carbo Jose M , Cornet-Masana Josep M
Published: December 2021

Acute myeloid leukaemia (AML) is a genetically heterogeneous haematopoietic neoplasm characterised by the accumulation of transformed immature blood progenitors in bone marrow. Since 1973, the backbone treatment has relied on the combination of cytarabine and an anthracycline, followed by allogeneic haematopoietic transplant if eligible. Therefore, the treatment decisions have largely revolved around chemotherapy drug intensity. Despite advances in our understanding of the underlying biology over the past decades, AML remains a therapeutic challenge as the overall survival is poor and treatment options are limited for relapsed/refractory AML or for unfit patients. After four decades without substantial changes, eight new noncytostatic drugs have been granted approval: vyxeos, enasidenib, gilteritinib, glasdegib, gemtuzumab ozogamicin, ivosidenib, midostaurin, and venetoclax. Despite promising preliminary results, some indications are based on early efficacy data, obtained in single-arm nonrandomised trials, highlighting the necessity for further validation in extended clinical trials. Interestingly, several druggable targets have been identified recently, associated with specific target-directed drugs. Based on the preclinical data available, great impact on clinical outcomes for patients with AML is expected, potentially increasing the therapeutic landscape for this disease.
Prevalence of Thromboembolic Complications in COVID-19 Infection: A Systematic Review and Meta-Analysis
Authors: Pergola Valeria , Ocagli Honoria , Lorenzoni Giulia , Azzolina Danila , Leoni Loira , Mancuso Daniela , Palermo Chiara , Previtero Marco , Iliceto Sabino , Gregori Dario , Di Salvo Giovanni
Published: December 2021

Introduction: The coronavirus disease (COVID-19) infection is proved to be involved in the onset of thromboembolism episodes. This study aims to evaluate the prevalence of thromboembolic complications in patients with COVID-19 from March until May 2020.

Methods: A literature review was conducted in MEDLINE (via PubMed), Scopus, Embase, Cochrane, and CINHAL without any language and date of publication restriction (Prospero registration number CRD42020186925). The inclusion criteria were as following: 1) patients with diagnosis of COVID-19; 2) occurrence of thromboembolic event, and 3) patients older than 18 years of age.

A multi-variable random effects model was computed accounting for correlations among outcomes by considering a heterogeneous compound symmetry covariance matrix.

Results: Observational studies included 2,442 participants from 268 to 7,999 participants per study, 1,014 (41.52%) were male and 825 (33.78%) were female. The multi-variable pooled event rate of acute myocardial infarction was rare, estimated to be 0.03 (95% confidence interval [CI]: 0.00–0.07; p=0.23); this is also true for the meta-analytical estimate of disseminated intravascular disease which was 0.04 (95% CI: 0.00–0.08; p=0.03). Conversely, other events were found to be more frequent. Indeed, the pooled proportion of pulmonary embolism was 0.14 (95% CI: 0.08–0.20; p<0.001), while the venous thromboembolic event rate is 0.15 (95% CI: 0.09-0.30; p=0.04). The pooled intrahospital mortality rate was equal to 0.12 (95% CI: 0.08–0.16; p<0.001).

Conclusions: Thromboembolic events, particularly venous thromboembolic event rate and pulmonary embolism, are a frequent complication in patients hospitalised with COVID-19. These findings suggest that the threshold for clinical suspicion should be low to trigger prompt diagnostic testing and that evaluation of therapeutic treatment should be considered in patients in intensive care units with COVID-19.
The Psychosocial Impact of Adolescent Food Allergy: A Review of The Literature
Authors: Newman Kristina , Knibb Rebecca
Published: December 2021

Previous research has suggested adolescents and young people with food allergies (FA) have the highest risk of fatal reactions to food. As the prevalence of FA has been increasing there has been increased demand for psychosocial support of adolescents with food allergy, with anxiety around food and social interactions affecting the lives of adolescents and their families. This narrative review aims to explore the psychosocial impact of having a FA in adolescence, including the suggested impact, coping, risk-taking behaviour, and effect of peers and social support. The review concludes with considerations of the wider community which may also have an effect.
Post Fever Uveoretinal Manifestations in an Immunocompetent Individual
Authors: Sanjay Srinivasan , Agrawal Sameeksha , Mahendradas Padmamalini , Kawali Ankush , Gupta Aditi , Shetty Rohit
Published: December 2021

Background: Post fever uveoretinal sequelae (PFURS) are the various uveoretinal manifestations seen after a systemic febrile illness in an immunocompetent individual caused by bacteria, viruses, and protozoa. These may be the result of a direct invasion by the pathogen or by indirect mechanism mediated through immune mechanisms. Method: The authors aim to review the ocular manifestations, utility of relevant diagnostic tests, management, and prognosis of PFURS. A comprehensive literature search was conducted on PubMed and Google Scholar databases with the search words “retinitis”, “choroiditis”, “neuroretinitis”, “macular edema”, “maculopathy”, “multifocal retinitis”, “chikungunya”, “dengue”, “West Nile”, “typhoid”, and “rickettsiosis”. Only articles published or translated into English language were considered. The key data were extracted, evaluated, and combined. Results: The authors search yielded 95 articles for the period between 1986 and May 2020. Painless blurring of vision was the most common symptom. Patients can have varied posterior segment manifestations, including vitritis, focal and multifocal patches of retinitis which could be unilateral or bilateral, optic nerve involvement, serous detachment at the macula, macular oedema, and localised involvement of the retinal vessels in the form of beading of the vessel wall, tortuosity, and perivascular sheathing. Conclusion: PFURS presents with a similar morphological pattern irrespective of the aetiology and follows a preset natural course before resolution. Treatment may or may not be required. Treating physicians need to be aware of this important ophthalmic condition even after complete resolution of fever.
Lymphatic Filariasis: An Immunologic Perspective
Authors: Mandanas Joshua Angelo Hermida
Published: December 2021

Introduction: This paper provides an overview of the current immunologic research findings of lymphatic filarial worms, which affect millions of people worldwide.

Objectives: This paper aims to discuss the immunologic features of lymphatic filarial worms. It also aims to highlight their potential anti-inflammatory actions and the use of anti-filarial drugs against COVID-19.

Methods: A literature review was performed to obtain insights on the immunologic features of lymphatic filarial worms.

Results: The CD4+ (Th2) response profile is the main defence against filarial worms. Modulation of human immune responses are primarily mediated by parasite-secreted peptides. Lymphatic filarial worms have anti-inflammatory potentials. Drug repurposing of diethylcarbamazepine, doxycycline, and ivermectin can be looked upon against COVID-19.

Conclusion: Lymphatic filarial worms have several immunologic effects on host immune systems, which promote chronic infection and curtail anti-inflammatory responses. Insights in this paper can serve as a guide for the understanding of immunologic aspects of lymphatic filarial worms.
City Wide Participatory Sensing of Air Quality
Authors: Rebeiro-Hargrave Andrew , Fung Pak Lun , Varjonen Samu , Huertas Andres , Sillanpää Salla , Luoma Krista , Hussein Tareq , Petäjä Tuukka , Timonen Hilkka , Limo Jukka , Nousiainen Ville , Tarkoma Sasu
Published: December 2021

Air pollution is a contributor to approximately one in every nine deaths annually. Air quality monitoring is being carried out extensively in urban environments. Currently, however, city air quality stations are expensive to maintain resulting in sparse coverage and data is not readily available to citizens. This can be resolved by city-wide participatory sensing of air quality fluctuations using low-cost sensors. We introduce new concepts for participatory sensing: a voluntary community-based monitoring data forum for stakeholders to manage air pollution interventions; an automated system (cyber-physical system) for monitoring outdoor air quality and indoor air quality; programmable platform for calibration and generating virtual sensors using data from low-cost sensors and city monitoring stations. To test our concepts, we developed a low-cost sensor to measure particulate matter (PM2.5), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3) with GPS. We validated our approach in Helsinki, Finland, with participants carrying the sensor for 3 months during six data campaigns between 2019 and 2021. We demonstrate good correspondence between the calibrated low-cost sensor data and city’s monitoring station measurements. Data analysis of their personal exposure was made available to the participants and stored as historical data for later use. Combining the location of low cost sensor data with participants public profile, we generate proxy concentrations for black carbon and lung deposition of particles between districts, by age groups and by the weekday.
Plant Sedimentary Ancient DNA From Far East Russia Covering the Last 28,000 Years Reveals Different Assembly Rules in Cold and Warm Climates
Authors: Huang Sichao , Stoof-Leichsenring Kathleen R. , Liu Sisi , Courtin Jeremy , Andreev Andrej A. , Pestryakova Luidmila. A. , Herzschuh Ulrike
Published: December 2021

Woody plants are expanding into the Arctic in response to the warming climate. The impact on arctic plant communities is not well understood due to the limited knowledge about plant assembly rules. Records of past plant diversity over long time series are rare. Here, we applied sedimentary ancient DNA metabarcoding targeting the P6 loop of the chloroplast trnL gene to a sediment record from Lake Ilirney (central Chukotka, Far Eastern Russia) covering the last 28 thousand years. Our results show that forb-rich steppe-tundra and dwarf-shrub tundra dominated during the cold climate before 14 ka, while deciduous erect-shrub tundra was abundant during the warm period since 14 ka. Larix invasion during the late Holocene substantially lagged behind the likely warmest period between 10 and 6 ka, where the vegetation biomass could be highest. We reveal highest richness during 28–23 ka and a second richness peak during 13–9 ka, with both periods being accompanied by low relative abundance of shrubs. During the cold period before 14 ka, rich plant assemblages were phylogenetically clustered, suggesting low genetic divergence in the assemblages despite the great number of species. This probably originates from environmental filtering along with niche differentiation due to limited resources under harsh environmental conditions. In contrast, during the warmer period after 14 ka, rich plant assemblages were phylogenetically overdispersed. This results from a high number of species which were found to harbor high genetic divergence, likely originating from an erratic recruitment process in the course of warming. Some of our evidence may be of relevance for inferring future arctic plant assembly rules and diversity changes. By analogy to the past, we expect a lagged response of tree invasion. Plant richness might overshoot in the short term; in the long-term, however, the ongoing expansion of deciduous shrubs will eventually result in a phylogenetically more diverse community.
Non-Coding RNA Networks in Pulmonary Hypertension
Authors: Zang Hongbin , Zhang Qiongyu , Li Xiaodong
Published: December 2021

Non-coding RNAs (ncRNAs) are involved in various cellular processes. There are several ncRNA classes, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). The detailed roles of these molecules in pulmonary hypertension (PH) remain unclear. We systematically collected and reviewed reports describing the functions of ncRNAs (miRNAs, lncRNAs, and circRNAs) in PH through database retrieval and manual literature reading. The characteristics of identified articles, especially the experimental methods, were carefully reviewed. Furthermore, regulatory networks were constructed using ncRNAs and their interacting RNAs or genes. These data were extracted from studies on pulmonary arterial smooth muscle cells, pulmonary artery endothelial cells, and pulmonary artery fibroblasts. We included 14 lncRNAs, 1 circRNA, 74 miRNAs, and 110 mRNAs in the constructed networks. Using these networks, herein, we describe the current knowledge on the role of ncRNAs in PH. Moreover, these networks actively provide an improved understanding of the roles of ncRNAs in PH. The results of this study are crucial for the clinical application of ncRNAs.
Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research
Authors: Douillard Venceslas , Castelli Erick C. , Mack Steven J. , Hollenbach Jill A. , Gourraud Pierre-Antoine , Vince Nicolas , Limou Sophie
Published: December 2021

The current SARS-CoV-2 pandemic era launched an immediate and broad response of the research community with studies both about the virus and host genetics. Research in genetics investigated HLA association with COVID-19 based onin silico, population, and individual data. However, they were conducted with variable scale and success; convincing results were mostly obtained with broader whole-genome association studies. Here, we propose a technical review of HLA analysis, including basic HLA knowledge as well as available tools and advice. We notably describe recent algorithms to infer and call HLA genotypes from GWAS SNPs and NGS data, respectively, which opens the possibility to investigate HLA from large datasets without a specific initial focus on this region. We thus hope this overview will empower geneticists who were unfamiliar with HLA to run MHC-focused analyses following the footsteps of the Covid-19|HLA & Immunogenetics Consortium.
Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis
Authors: Chen Deng , Tang Ting-Xuan , Deng Hai , Yang Xiang-Ping , Tang Zhao-Hui
Published: December 2021

Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It plays a vital role in health maintenance and disease prevention, and the congenital deficiency of IL-7 signaling leads to profound immunodeficiency. IL-7 contributes to host defense by regulating the development and homeostasis of immune cells, including T lymphocytes, B lymphocytes, and natural killer (NK) cells. Clinical trials of recombinant IL-7 have demonstrated safety and potent immune reconstitution effects. In this article, we discuss IL-7 and its functions in immune cell development, drawing on a substantial body of knowledge regarding the biology of IL-7. We aim to answer some remaining questions about IL-7, providing insights essential for designing new strategies of immune intervention.
Mucosal Vaccination Against Periodontal Disease: Current Status and Opportunities
Authors: Vaernewyck Victor , Arzi Boaz , Sanders Niek N. , Cox Eric , Devriendt Bert
Published: December 2021

Approximately 9 out of 10 adults have some form of periodontal disease, an infection-induced inflammatory disease of the tooth-supporting tissues. The initial form, gingivitis, often remains asymptomatic, but this can evolve into periodontitis, which is typically associated with halitosis, oral pain or discomfort, and tooth loss. Furthermore, periodontitis may contribute to systemic disorders like cardiovascular disease and type 2 diabetes mellitus. Control options remain nonspecific, time-consuming, and costly; largely relying on the removal of dental plaque and calculus by mechanical debridement. However, while dental plaque bacteria trigger periodontal disease, it is the host-specific inflammatory response that acts as main driver of tissue destruction and disease progression. Therefore, periodontal disease control should aim to alter the host’s inflammatory response as well as to reduce the bacterial triggers. Vaccines may provide a potent adjunct to mechanical debridement for periodontal disease prevention and treatment. However, the immunopathogenic complexity and polymicrobial aspect of PD appear to complicate the development of periodontal vaccines. Moreover, a successful periodontal vaccine should induce protective immunity in the oral cavity, which proves difficult with traditional vaccination methods. Recent advances in mucosal vaccination may bridge the gap in periodontal vaccine development. In this review, we offer a comprehensive overview of mucosal vaccination strategies to induce protective immunity in the oral cavity for periodontal disease control. Furthermore, we highlight the need for additional research with appropriate and clinically relevant animal models. Finally, we discuss several opportunities in periodontal vaccine development such as multivalency, vaccine formulations, and delivery systems.
Effect of Extracellular Vesicles Derived From Lactobacillus plantarum Q7 on Gut Microbiota and Ulcerative Colitis in Mice
Authors: Hao Haining , Zhang Xinyi , Tong Lingjun , Liu Qiqi , Liang Xi , Bu Yushan , Gong Pimin , Liu Tongjie , Zhang Lanwei , Xia Yongjun , Ai Lianzhong , Yi Huaxi
Published: December 2021

Probiotics plays an important role in regulating gut microbiota and maintaining intestinal homeostasis. Extracellular vesicles (EVs) derived from probiotics have emerged as potential mediators of host immune response and anti-inflammatory effect. However, the anti-inflammatory effect and mechanism of probiotics derived EVs on inflammatory bowel disease (IBD) remains unclear. In this study, the effect of Lactobacillus plantarum Q7-derived extracellular vesicles (Q7-EVs) on gut microbiota and intestinal inflammation was investigated in C57BL/6J mice. The results showed that Q7-EVs alleviated DSS-induced colitis symptoms, including colon shortening, bleeding, and body weight loss. Consumption of Q7-EVs reduced the degree of histological damage. DSS-upregulated proinflammatory cytokine levels including IL-6, IL-1β, IL-2 and TNF-α were reduced significantly by Q7-EVs (p < 0.05). 16S rRNA sequencing results showed that Q7-EVs improved the dysregulation of gut microbiota and promoted the diversity of gut microbiota. It was observed that the pro-inflammatory bacteria (Proteobacteria) were reduced and the anti-inflammatory bacteria (Bifidobacteria and Muribaculaceae) were increased. These findings indicated that Q7-EVs might alleviate DSS-induced ulcerative colitis by regulating the gut microbiota.