bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinants Influencing the Application of Lean Accounting: The Case of Vietnamese Garment Firms
Authors: Nguyen Thi Minh Phuong , Ngo Thi Hai Chau
Published: May 2023

The shift towards lean production is gradually replacing traditional mass production, and lean accounting is also being mentioned to evaluate operational efficiency based on the lean philosophy, eliminating waste, and simplifying direct cost aggregation along the value stream to improve productivity, distribution, quality, and service. This study aims to evaluate the impact of various factors on the adoption of lean accounting in Vietnamese garment firms based on data collected from 242 survey questionnaires completed by managers and accountants of Vietnamese garment firms. Through Cronbach’s Alpha test, EFA test, and multiple regression analysis to verify and forecast information, eight determinants affecting the adoption of lean accounting in Vietnamese garment firms are arranged in descending order of influence, including leadership, size, cost of implementation, resources, accounting department, education and training, culture, and competitive pressure. Based on the findings, recommendations are proposed to management businesses and agencies to address shortcomings in the process of applying lean accounting, contributing to making it one of the most effective tools in promoting product development and continuous improvement, enhancing quality and production efficiency.
Precious Metals Comovements in Turbulent Times: COVID-19 and the Ukrainian Conflict
Authors: Michis Antonis A.
Published: May 2023

We examined the evolution of cross-market linkages between four major precious metals and US stock returns, before (Phase I) and after (Phase II) the COVID-19 outbreak. Phase II was also extended to encompass the Ukrainian conflict, which prolonged the period of uncertainty in financial markets. Due to the increase in volatility observed in Phase II, we used a heteroskedasticity-adjusted correlation coefficient to examine the evolution of correlation changes since the COVID-19 outbreak. We also propose a relevant dissimilarity measure in multidimensional scaling analysis that can be used for depicting associations between financial returns in turbulent times. Our results suggest that (i) the correlation levels of gold, silver, platinum, and palladium returns with US stock returns have not changed substantially since the COVID-19 outbreak, and (ii) all precious metal returns exhibit movements that are less synchronized with US stock returns, with palladium and gold being the least synchronized.
Effects of High-Intensity Functional Training (HIFT) on the Functional Capacity, Frailty, and Physical Condition of Older Adults with Mild Cognitive Impairment: A Blind Randomized Controlled Clinical Trial
Authors: Rivas-Campo Yulieth , Aibar-Almazán Agustín , Afanador-Restrepo Diego Fernando , García-Garro Patricia Alexandra , Vega-Ávila Gloria Cecilia , Rodríguez-López Carlos , Castellote-Caballero Yolanda , Carcelén-Fraile María del Carmen , Lavilla-Lerma María Leyre
Published: May 2023

Physical exercise has been established as an intervention in the integral approach for the physical, functional, and social health of older adults. The objective of this study was to determine the effects of a high-intensity functional training (HIFT) program on the physical condition and functional capacity of an elderly Colombian population with mild cognitive impairment. This research corresponds to a blind randomized controlled clinical trial. A total of 169 men and women aged over 65 years were evaluated and distributed in two groups: the experimental group that received a 12-week HIFT intervention (n = 82) and the control group (n = 87) that received general recommendations on the benefits of physical exercise. The outcome variables included physical condition, assessed using the Senior Fitness battery (SNB); Fried’s frailty phenotype was applied, and gait and balance were assessed using the Tinetti scale. For the functional variables, activities of daily living, instrumental activities of daily living, and advanced activities of daily living were evaluated. All variables were measured pre- and post-intervention. Statistically significant improvements were observed in the IG for gait stability and balance (p < 0.001), as well as for independence in activities of daily living (p = 0.003), and instrumental and advanced activities (p < 0.001). Likewise, greater functionality was found when assessed with the SNB (p < 0.001), except for upper limb strength. The frailty classification did not show changes post-intervention (p = 0.170) nor in the group x time interaction. MANCOVA analysis showed that regardless of gender, health level, age, BMI, cognition, and health level, the HIFT intervention produced better results in functional capacity, balance, and gait (F = 0.173, p < 0.001, Wilks’ λ = 88.231).
HMGA1 and FOXM1 Cooperate to Promote G2/M Cell Cycle Progression in Cancer Cells
Authors: Zheng Qingfang , Luo Ziyang , Xu Mingjun , Ye Shazhou , Lei Yuxin , Xi Yang
Published: May 2023

HMGA1 is a chromatin-binding protein and performs its biological function by remodeling chromatin structure or recruiting other transcription factors. However, the role of abnormally high level of HMGA1 in cancer cells and its regulatory mechanism still require further investigation. In this study, we performed a prognostic analysis and showed that high level of either HMGA1 or FOXM1 was associated with poor prognosis in various cancers based on the TCGA database. Furthermore, the expression pattern of HMGA1 and FOXM1 showed a significant strong positive correlation in most type of cancers, especially lung adenocarcinoma, pancreatic cancer and liver cancer. Further analysis of the biological effects of their high correlation in cancers suggested that cell cycle was the most significant related pathway commonly regulated by HMGA1 and FOXM1. After knockdown of HMGA1 and FOXM1 by specific siRNAs, an obvious increased G2/M phase was observed in the siHMGA1 and siFOXM1 groups compared to the siNC group. The expression levels of key G2/M phase regulatory genes PLK1 and CCNB1 were significantly downregulated. Importantly, HMGA1 and FOXM1 were identified to form a protein complex and co-located in the nucleus based on co-immunoprecipitation and immunofluorescence staining, respectively. Thus, our results provide the basic evidence that HMGA1 and FOXM1 cooperatively accelerate cell cycle progression by up-regulating PLK1 and CCNB1 to promote cancer cell proliferation.
(R)-(+)-3,5-Dinitro-N-(1-phenylethyl)benzothioamide
Authors: Donahue Matthew G. , Crull Emily
Published: May 2023

(R)-(+)-3,5-dinitro-N-(1-phenylethyl)benzothioamide 1 is a potential chiral solvating agent (CSA) for the spectral resolution of enantiomers via 1H NMR spectroscopy. The single enantiomer of 1 was synthesized from commercially available (R)-(+)-a-methylbenzylamine 2 in two steps with 85% yield.
Influence of Alumina Grade on Sintering Properties and Possible Application in Binder Jetting Additive Technology
Authors: Kwiatkowski Maciej , Marczyk Joanna , Putyra Piotr , Kwiatkowski Michał , Przybyła Szymon , Hebda Marek
Published: May 2023

Alumina is one of the most popular ceramic materials widely used in both tooling and construction applications due to its low production cost, and high properties. However, the final properties of the product depend not only on the purity of the powder, but also, e.g., on its particle size, specific surface area, and the production technology used. These parameters are particularly important in the case of choosing additive techniques for the production of details. Therefore, the article presents the results of comparing five grades of Al2O3 ceramic powder. Their specific surface area (via Brunauer–Emmett–Teller (BET) and Barrett–Joyner–Halenda (BJH) methods), particle size distribution, and phase composition by X-ray diffraction (XRD) were determined. Moreover, the surface morphology was characterized by the scanning electron microscopy (SEM) technique. The discrepancy between generally available data and the results obtained from measurements has been indicated. Moreover, the method of spark plasma sintering (SPS), equipped with the registration system of the position of the pressing punch during the process, was used to determine the sinterability curves of each of the tested grades of Al2O3 powder. Based on the obtained results, a significant influence of the specific surface area, particle size, and the width of their distribution at the beginning of the Al2O3 powder sintering process was confirmed. Furthermore, the possibility of using the analyzed variants of powders for binder jetting technology was assessed. The dependence of the particle size of the powder used on the quality of the printed parts was demonstrated. The procedure presented in this paper, which involves analyzing the properties of alumina varieties, was used to optimize the Al2O3 powder material for binder jetting printing. The selection of the best powder in terms of technological properties and good sinterability makes it possible to reduce the number of 3D printing processes, which makes it more economical and less time-consuming.
Cytotoxicity and Microbiological Properties of Copolymers Comprising Quaternary Ammonium Urethane-Dimethacrylates with Bisphenol A Glycerolate Dimethacrylate and Triethylene Glycol Dimethacrylate
Authors: Chrószcz-Porębska Marta W. , Barszczewska-Rybarek Izabela M. , Kazek-Kęsik Alicja , Ślęzak-Prochazka Izabella
Published: May 2023

Using dental composite restorative materials with a copolymeric matrix chemically modified towards bioactive properties can help fight secondary caries. In this study, copolymers of 40 wt.% bisphenol A glycerolate dimethacrylate, 40 wt.% quaternary ammonium urethane-dimethacrylates (QAUDMA-m, where m represents 8, 10, 12, 14, 16 and 18 carbon atoms in the N-alkyl substituent), and 20 wt.% triethylene glycol dimethacrylate (BG:QAm:TEGs) were tested for (i) cytotoxicity on the L929 mouse fibroblast cell line; (ii) fungal adhesion, fungal growth inhibition zone, and fungicidal activity against C. albicans; and (iii) bactericidal activity against S. aureus and E. coli. BG:QAm:TEGs had no cytotoxic effects on L929 mouse fibroblasts because the reduction of cell viability was less than 30% compared to the control. BG:QAm:TEGs also showed antifungal activity. The number of fungal colonies on their surfaces depended on the water contact angle (WCA). The higher the WCA, the greater the scale of fungal adhesion. The fungal growth inhibition zone depended on the concentration of QA groups (xQA). The lower the xQA, the lower the inhibition zone. In addition, 25 mg/mL BG:QAm:TEGs suspensions in culture media showed fungicidal and bactericidal effects. In conclusion, BG:QAm:TEGs can be recognized as antimicrobial biomaterials with negligible biological patient risk.
Insight into the Desolvation of Quaternary Ammonium Cation with Acetonitrile as a Solvent in Hydroxyl-Flat Pores: A First-Principles Calculation
Authors: Liu Fudong , Yang Shaobin , Zhang Xu , Tang Shuwei , Xia Yingkai
Published: May 2023

Supercapacitors have a wide range of applications in high-technology fields. The desolvation of organic electrolyte cations affects the capacity size and conductivity of supercapacitors. However, few relevant studies have been published in this field. In this experiment, the adsorption behavior of porous carbon was simulated with first-principles calculations using a graphene bilayer with a layer spacing of 4–10 Å as a hydroxyl-flat pore model. The reaction energies of quaternary ammonium cations, acetonitrile, and quaternary ammonium cationic complexes were calculated in a graphene bilayer with different interlayer spacings, and the desolvation behavior of TEA+ and SBP+ ions was described. The critical size for the complete desolvation of [TEA(AN)]+ was 4.7 Å, and the partial desolvation size ranged from 4.7 to 4.8 Å. The critical size for the complete desolvation of [SBP(AN)]+ was 5.2 Å, and the partial desolvation size ranged from 5.2 to 5.5 Å. As the ionic radius of the quaternary ammonium cation decreased, the desolvation size showed a positive trend. A density of states (DOS) analysis of the desolvated quaternary ammonium cations embedded in the hydroxyl-flat pore structure showed that the conductivity of the hydroxyl-flat pore was enhanced after gaining electrons. The results of this paper provide some help in selecting organic electrolytes to improve the capacity and conductivity of supercapacitors.
Corrosion Behavior of TiMoNbX (X = Ta, Cr, Zr) Refractory High Entropy Alloy Coating Prepared by Laser Cladding Based on TC4 Titanium Alloy
Authors: Liu Liang , Liu Hongxi , Zhang Xiaowei , Wang Yueyi , Hao Xuanhong
Published: May 2023

TiMoNbX (X = Cr, Ta, Zr) RHEA coatings were fabricated on TC4 titanium alloy substrate using laser cladding technology. The microstructure and corrosion resistance of the RHEA were studied by XRD, SEM and an electrochemical workstation. The results show that the TiMoNb series RHEA coating was composed of a columnar dendrite (BCC) phase, a rod-like second phase, a needle-like structure and equiaxed dendrite, but the TiMoNbZr RHEA coating showed high-density defects, similar to those in TC4 titanium alloy, which were composed of small non-equiaxed dendrites and lamellar α’(Ti). In the 3.5% NaCl solution, compared with TC4 titanium alloy, the RHEA had a lower corrosion sensitivity and fewer corrosion sites, showing better corrosion resistance. The corrosion resistance of the RHEA ranged from strong to weak in this order: TiMoNbCr, TiMoNbZr, TiMoNbTa and TC4. The reason is that the electronegativity of different elements is different, and the speeds of the formation of the passivation film were very different. In addition, the positions of pores appearing in the laser cladding process also affected the corrosion resistance.
Strategies for the Covalent Anchoring of a BMP-2-Mimetic Peptide to PEEK Surface for Bone Tissue Engineering
Authors: Cassari Leonardo , Zamuner Annj , Messina Grazia Maria Lucia , Marsotto Martina , Chang Hao-chen , Coward Trevor , Battocchio Chiara , Iucci Giovanna , Marletta Giovanni , Di Silvio Lucy , Dettin Monica
Published: May 2023

Researchers in the field of tissue engineering are always searching for new scaffolds for bone repair. Polyetheretherketone (PEEK) is a chemically inert polymer that is insoluble in conventional solvents. PEEK’s great potential in tissue engineering applications arises from its ability to not induce adverse reactions when in contact with biological tissues and its mechanical properties, which are similar to those of human bone. These exceptional features are limited by the bio-inertness of PEEK, which causes poor osteogenesis on the implant surface. Here, we demonstrated that the covalent grafting of the sequence (48–69) mapped on the BMP-2 growth factor (GBMP1α) significantly enhances the mineralization and gene expression of human osteoblasts. Different chemical methods were employed for covalently grafting the peptide onto 3D-printed PEEK disks: (a) the reaction between PEEK carbonyls and amino-oxy groups inserted in the peptides’ N-terminal sites (oxime chemistry) and (b) the photoactivation of azido groups present in the peptides’ N-terminal sites, which produces nitrene radicals able to react with PEEK surface. The peptide-induced PEEK surface modification was assessed using X-ray photoelectron measurements, while the superficial properties of the functionalized material were analyzed by means of atomic force microscopy and force spectroscopy. Live and dead assays and SEM measurements showed greater cell cover on functionalized samples than the control, without any cytotoxicity induction. Moreover, functionalization improved the rate of cell proliferation and the amount of calcium deposits, as demonstrated by the AlamarBlue™ and alizarin red results, respectively. The effects of GBMP1α on h-osteoblast gene expression were assayed using quantitative real-time polymerase chain reaction.
Seismic Performance of Precast Short-Limb Shear Wall with the Bundled Connection at Different Axial Compression Ratios
Authors: Chen Gang , Yu Zihao , Zhang Xiaohui , Yang Hailong , Zhang Qian , Feng Jian , Cai Jianguo
Published: May 2023

In order to investigate the seismic performance of a precast shear wall with a new bundled connection under a high axial compressive ratio, three full-scale precast short-limb shear walls and one full-scale cast-in-place short-limb shear wall were manufactured and loaded under cycling loading. The results show that the precast short-limb shear wall with a new bundled connection has a similar damage mode and crack evolution to the cast-in-place shear wall. Under the same axial compression ratio, the bearing capacity, ductility coefficient, stiffness, and energy dissipation capacity of the precast short-limb shear wall were better, and its seismic performance is related to the axial compression ratio, with the increase of the axial compression ratio. The embedded bellows can limit the cracking of the wall but have little effect on the bearing capacity and stiffness degradation performance. Furthermore, the bond between the vertical steel bars extending into the preformed holes and grouting materials was demonstrated to be reliable, thus ensuring the integrity of the precast specimens.
The Effect of Radial-Shear Rolling Deformation Processing on the Structure and Properties of Zr-2.5Nb Alloy
Authors: Ozhmegov Kirill , Kawalek Anna , Naizabekov Abdrakhman , Panin Evgeniy , Lutchenko Nikita , Sultanbekov Sanzhar , Magzhanov Medet , Arbuz Alexandr
Published: May 2023

The rheological properties of the Zr-2.5Nb alloy by the strain rate range of 0.5–15 s−1 and by the temperature range of 20–770 °C was studied. The dilatometric method for phase states temperature ranges was experimentally determined. A material properties database for computer FEM simulation regards the indicated temperature-velocity ranges were created. Using this database and DEFORM-3D FEM-softpack, the radial shear rolling complex process numerical simulation was carried out. The contributed conditions for the ultrafine-grained state alloy structure refinement were determined. Based on the simulation results, a full-scale experiment of Zr-2.5Nb rod rolling a on a radial-shear rolling mill RSP-14/40 was carried out. It takes in seven passes from a diameter of 37–20 mm with a total diameter reduction ε = 85%. According to this case simulation data, the total equivalent strain in the most processed peripheral zone 27.5 mm/mm was reached. Due to the complex vortex metal flow, the equivalent strain over the section distribution was uneven with a gradient reducing towards the axial zone. This fact should have a deep effect on the structure change. Changes and structure gradient by sample section EBSD mapping with 2 mm resolution were studied. The microhardness section gradient by the HV 0.5 method was also studied. The axial and central zones of the sample by the TEM method were studied. The rod section structure has an expressed gradient from the formed equiaxed ultrafine-grained (UFG) structure on a few outer millimeters of the peripheral section to the elongated rolling texture in the center of the bar. The work shows the possibility of processing with the gradient structure obtaining and enhanced properties for the Zr-2.5Nb alloy, and a database for this alloy FEM numerical simulations are also presents.
Effects of Steel Slag Powder Content and Curing Condition on the Performance of Alkali-Activated Materials Based UHPC Matrix
Authors: Shi Kangyi , Deng Hongyang , Hu Jinxuan , Zhou Junqi , Cai Xinhua , Liu Zhiwei
Published: May 2023

The accumulation of steel slag and other industrial solid wastes has caused serious environmental pollution and resource waste, and the resource utilization of steel slag is imminent. In this paper, alkali-activated ultra-high-performance concrete (AAM-UHPC) was prepared by replacing ground granulated blast furnace slag (GGBFS) powder with different proportions of steel slag powder, and its workability, mechanical properties, curing condition, microstructure, and pore structure were investigated. The results illustrate that the incorporation of steel slag powder can significantly delay the setting time and improve the flowability of AAM-UHPC, making it possible for engineering applications. The mechanical properties of AAM-UHPC showed a tendency to increase and then decrease with the increase in steel slag dosing and reached their best performance at a 30% dosage of steel slag. The maximum compressive strength and flexural strength are 157.1 MPa and 16.32 Mpa, respectively. High-temperature steam or hot water curing at an early age was beneficial to the strength development of AAM-UHPC, but continuous high-temperature, hot, and humid curing would lead to strength inversion. When the dosage of steel slag is 30%, the average pore diameter of the matrix is only 8.43 nm, and the appropriate steel slag dosage can reduce the heat of hydration and refine the pore size distribution, making the matrix denser.
Numerical Investigation on the Compressive Behavior of Desert Sand-Based Backfill Material: Parametric Study
Authors: Yan Haitian , Liu Honglin , Li Guodong , Wang Xiangyu , Hang Yinjian
Published: May 2023

As a key node in the promotion of the “Western Development” strategy in Xinjiang, China, the large-scale mining of coal resources is bound to cause a series of ecological and environmental problems, such as surface subsidence. Desert areas are widely distributed in Xinjiang, and from the perspective of reserves and sustainable development, it is crucial to fully utilize desert sand to make filling materials and predict its mechanical strength. In order to promote the application of High Water Backfill Material (HWBM) in mining engineering, a modified HWBM doped with Xinjiang Kumutage desert sand was used to prepare a desert sand-based backfill material, and its mechanical properties were tested. The discrete element particle flow software PFC3D is used to construct a three-dimensional numerical model of desert sand-based backfill material. The parameters such as sample sand content, porosity, desert sand particle size distribution, and model size are changed to study their impact on the bearing performance and scale effect of desert sand-based backfill materials. The results indicate that a higher content of desert sand can effectively improve the mechanical properties of HWBM specimens. The stress–strain relationship inverted by the numerical model is highly consistent with the measured results of desert sand-based backfill materials. Improving the particle size distribution of desert sand and reducing the porosity of filling materials within a certain range can significantly improve the bearing capacity of desert sand-based backfill materials. The influence of changing the range of microscopic parameters on the compressive strength of desert sand-based backfill materials was analyzed. This study provides a desert sand-based backfill material that meets the requirements of mine filling, and predicts its strength through numerical simulation.
Highly Efficient and Exceptionally Durable Photooxidation Properties on Co3O4/g-C3N4 Surfaces
Authors: Dai Yelin , Feng Ziyi , Zhong Kang , Tian Jianfeng , Wu Guanyu , Liu Qing , Wang Zhaolong , Hua Yingjie , Liu Jinyuan , Xu Hui , Zhu Xingwang
Published: May 2023

Water pollution is a significant social issue that endangers human health. The technology for the photocatalytic degradation of organic pollutants in water can directly utilize solar energy and has a promising future. A novel Co3O4/g-C3N4 type-II heterojunction material was prepared by hydrothermal and calcination strategies and used for the economical photocatalytic degradation of rhodamine B (RhB) in water. Benefitting the development of type-II heterojunction structure, the separation and transfer of photogenerated electrons and holes in 5% Co3O4/g-C3N4 photocatalyst was accelerated, leading to a degradation rate 5.8 times higher than that of pure g-C3N4. The radical capturing experiments and ESR spectra indicated that the main active species are •O2− and h+. This work will provide possible routes for exploring catalysts with potential for photocatalytic applications.
Insights into the Mechanism of Graphene Acting on Water and Chloride Ion Permeability of Cement-Based Materials
Authors: Dong Jianmiao , Zhuang Jiaqiao , Li Wanjin , Zou Mingxuan , He Qi , Luo Shuqiong
Published: May 2023

Due to its excellent mechanical properties and high aspect ratio, graphene can significantly improve the water and chloride ion permeability resistance of cementitious materials. However, few studies have investigated the effect of graphene size on the water and chloride ion permeability resistance of cementitious materials. The main issues are as follows: How do different sizes of graphene affect the water and chloride ion permeability resistance of cement-based materials, and by what means do they affect these properties? To address these issues, in this paper, two different sizes of graphene were used to prepare graphene dispersion, which was then mixed with cement to make graphene-reinforced cement-based materials. The permeability and microstructure of samples were investigated. Results show that the addition of graphene effectively improved both the water and chloride ion permeability resistance of cement-based materials significantly. The SEM (scanning electron microscope) images and XRD (X-ray diffraction) analysis show that the introduction of either type of graphene could effectively regulate the crystal size and morphology of hydration products and reduce the crystal size and the number of needle-like and rod-like hydration products. The main types of hydrated products are calcium hydroxide, ettringite, etc. The template effect of large-size graphene was more obvious, and a large number of regular flower-like cluster hydration products were formed, which made the structure of cement paste more compact and thus significantly improved the resistance to the penetration of water and chloride ions into the matrix of the concrete.
The Role of ROR1 in Chemoresistance and EMT in Endometrial Cancer Cells
Authors: Lee Kyung-Jun , Kim Nam-Hyeok , Kim Hyeong Su , Kim Youngmi , Lee Jae-Jun , Kim Jung Han , Cho Hye-Yon , Jeong Soo Young , Park Sung Taek
Published: May 2023

Background and Objectives: Receptor tyrosine kinase-like orphan receptor type 1 (ROR1) plays a critical role in embryogenesis and is overexpressed in many malignant cells. These characteristics allow ROR1 to be a potential new target for cancer treatment. The aim of this study was to investigate the role of ROR1 through in vitro experiments in endometrial cancer cell lines. Materials and Methods: ROR1 expression was identified in endometrial cancer cell lines using Western blot and RT-qPCR. The effects of ROR1 on cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) markers were analyzed in two endometrial cancer cell lines (HEC-1 and SNU-539) using either ROR1 silencing or overexpression. Additionally, chemoresistance was examined by identifying MDR1 expression and IC50 level of paclitaxel. Results: The ROR1 protein and mRNA were highly expressed in SNU-539 and HEC-1 cells. High ROR1 expression resulted in a significant increase in cell proliferation, migration, and invasion. It also resulted in a change of EMT markers expression, a decrease in E-cadherin expression, and an increase in Snail expression. Moreover, cells with ROR1 overexpression had a higher IC50 of paclitaxel and significantly increased MDR1 expression. Conclusions: These in vitro experiments showed that ROR1 is responsible for EMT and chemoresistance in endometrial cancer cell lines. Targeting ROR1 can inhibit cancer metastasis and may be a potential treatment method for patients with endometrial cancer who exhibit chemoresistance.
Drug-Induced Thrombocytopenia Due to Nintedanib during Treatment of Idiopathic Pulmonary Fibrosis
Authors: Dumic Igor , Charokopos Antonios , Parmar Angadabir , Grant Christopher R. , Cosiquien Ronin Joshua S. , Dagnon da Silva Marilia , Petcu Emilia
Published: May 2023

Nintedanib is a tyrosine kinase inhibitor that was approved for the treatment of patients with idiopathic pulmonary fibrosis in 2014. The most common side effect of Nintedanib is diarrhea, and thrombocytopenia is a rare side effect of Nintedanib. The exact mechanism is unknown, and the literature lacks case reports of this phenomenon. Here, we report the case of a patient who developed thrombocytopenia 12 weeks after starting treatment with Nintedanib. The patient underwent an extensive work up for infectious, hematological, autoimmune, and neoplastic diseases. The patient’s thrombocytopenia resolved following cessation of Nintedanib. This case is significant as it reports a rare side effect that might have detrimental consequences if not recognized and treated timely. Additionally, the onset of thrombocytopenia was delayed, 3 months after the initiation of Nintedanib. We also highlight the various literature regarding drug-induced thrombocytopenia and explore the necessary work-up needed to exclude other potential diagnoses. We hope to advocate for multidisciplinary teams to be aware of patients with pulmonary fibrosis on Nintedanib so that this adverse effect can be recognized promptly.
Hydrogen Solid State Storage on MgH2 Compacts for Mass Applications
Authors: Fruchart Daniel , Jehan Michel , Skryabina Nataliya , de Rango Patricia
Published: May 2023

The mass storage of hydrogen is a challenge considering large industrial applications and continuous distribution, e.g., for domestic use as a future energy carrier that respects the environment. For a long time, molecular hydrogen was stored and distributed, either as a gas (pressurized up to 75 MPa) or as a cryogenic liquid (20.4 K). Furthermore, the atomic storage of hydrogen in the solid-state form via metallic or covalent compounds is still the subject of intense research and limited to a small scale for some practical developments. In addition, other type H chemical storage routes are being tested, such as ammonia and LOHC (Liquid Organic Hydrogen Carrier), etc. In any case, the main constraint remains security. However, Hydrogen Solid State Storage (HSSS) using MgH2 bodies has been shown to be feasible in terms of process and safety. Furthermore, its intrinsic volumetric densification was proven to be much better performing with 106:70:45 kgH2/m3 for solid (RT):LH (20.4 K):gas (75 MPa), respectively. Very early on, fairly reactive MgH2-based pellets were produced (for max. ~27 tons/year) at McPhy Energy using a series of unique and self-built installations. Thus, the design of large instrumented reservoirs was undertaken thanks to fundamental research first carried out at the CNRS. So, prototypes of storage units from 100 to ~5500 kWh have been produced. However, McPhy took other routes a few years ago (smelting and refueling stations) because the HSSS market was not merging at that time. Today, a new operator, Jomi–Leman, therefore, decided to try the challenge again focusing on applications with on-site production and mass HSSS.
Estimation of Component Activities and Molar Excess Gibbs Energy of 19 Binary Liquid Alloys from Partial Pair Distribution Functions in Literature
Authors: Wang Chunlong , Chen Xiumin , Tao Dongping
Published: May 2023

This work proposes a new method for estimating the molar excess Gibbs energy and activity of liquid alloy based on recent research. The local composition theory provides a connection between the structures of liquid alloys and the thermodynamic models. The partial pair distribution function (PPDF) was utilized to calculate the parameters of the MIVM, RSM, Wilson, and NRTL. The statistics of the number of molecular pairs of MIVM and RSM were rewritten, which resulted in new forms of the two models. To enhance the NRTL’s estimation performance, the coordination number was incorporated into it (M-NRTL). The aforementioned model and Quasi-chemical model (QCM) were utilized to estimate the excess Gibbs energy and activity of 19 alloys. The alloys contained multiple sets of PPDFs, which enabled the calculation of multiple sets of model parameters. The work examined the impact of expressing the model parameters as first-order linear functions of the components or as constants on the accuracy of the estimation. The parameters were treated as constants. MIVM, RSM, and M-NRTL provided an average relative deviation (ARD) of activity of less than ±20% for 15, 10, and 9 alloys by estimation. When model parameters were expressed as a function of components, QCM showed the best estimation performance, having nine alloys with an ARD of less than ±20%. The number of alloys with an ARD of less than ±20% corresponding to MIVM, RSM, Wilson, NRTL, and M-NRTL was six, five, three, five, and two, respectively. This new method offers simplicity, numerical calculation stability, and excellent reproducibility.
Data-Driven Inverse Problem for Optimizing the Induction Hardening Process of C45 Spur-Gear
Authors: Garois Sevan , Daoud Monzer , Chinesta Francisco
Published: May 2023

Inverse problems can be challenging and interesting to study in the context of metallurgical processes. This work aims to carry out a method for inverse modeling for simultaneous double-frequency induction hardening process. In this investigation, the experimental measured hardness profiles were considered as input data, while the output data were the process parameters. For this purpose experiments were carried out on C45 steel spur-gear. The method is based on machine learning algorithms and data treatment for dealing with inverse approach issues. In addition to the inverse modeling, a forward problem-based verification completes the study. It was found that according to promising results that this method is suitable and applicable for inverse problem of hardness modeling.
Influence of Aluminum and Copper on Mechanical Properties of Biocompatible Ti-Mo Alloys: A Simulation-Based Investigation
Authors: Ashkani Omid , Tavighi Mohammad Reza , Karamimoghadam Mojtaba , Moradi Mahmoud , Bodaghi Mahdi , Rezayat Mohammad
Published: May 2023

The use of titanium and titanium-based alloys in the human body due to their resistance to corrosion, implant ology and dentistry has led to significant progress in promoting new technologies. Regarding their excellent mechanical, physical and biological performance, new titanium alloys with non-toxic elements and long-term performance in the human body are described today. The main compositions of Ti-based alloys and properties comparable to existing classical alloys (C.P. TI, Ti-6Al-4V, Co-Cr-Mo, etc.) are used for medical applications. The addition of non-toxic elements such as Mo, Cu, Si, Zr and Mn also provides benefits, such as reducing the modulus of elasticity, increasing corrosion resistance and improving biocompatibility. In the present study, when choosing Ti-9Mo alloy, aluminum and copper (Cu) elements were added to it. These two alloys were chosen because one element is considered a favorable element for the body (copper) and the other element is harmful to the body (aluminum). By adding the copper alloy element to the Ti-9Mo alloy, the elastic modulus decreases to a minimum value of 97 GPa, and the aluminum alloy element increases the elastic modulus up to 118 GPa. Due to their similar properties, Ti-Mo-Cu alloys are found to be a good optional alloy to use.
Direct Synthesis of Mn3[Fe(CN)6]2·nH2O Nanosheets as Novel 2D Analog of Prussian Blue and Material for High-Performance Metal-Ion Batteries
Authors: Lobinsky Artem A. , Kaneva Maria V. , Tenevich Maxim I. , Popkov Vadim I.
Published: May 2023

Rechargeable metal-ion batteries (RMIBs) are prospective highly effective and low-cost devices for energy storage. Prussian blue analogues (PBAs) have become a subject of significant interest for commercial applications owing to their exceptional specific capacity and broad operational potential window as cathode materials for rechargeable metal-ion batteries. However, the limiting factors for its widespread use are its poor electrical conductivity and stability. The present study describes the direct and simple synthesis of 2D nanosheets of MnFCN (Mn3[Fe(CN)6]2·nH2O) on nickel foam (NF) via a successive ionic layer deposition (SILD) method, which provided more ion diffusion and electrochemical conductivity. MnFCN/NF exhibited exceptional cathode performance for RMIBs, delivering a high specific capacity of 1032 F/g at 1 A/g in an aqueous 1M NaOH electrolyte. Additionally, the specific capacitance reached the remarkable levels of 327.5 F/g at 1 A/g and 230 F/g at 0.1 A/g in 1M Na2SO4 and 1M ZnSO4 aqueous solutions, respectively.
A Wireless, High-Quality, Soft and Portable Wrist-Worn System for sEMG Signal Detection
Authors: Liang Zekai , Wang Xuanqi , Guo Jun , Ye Yuanming , Zhang Haoyang , Xie Liang , Tao Kai , Zeng Wen , Yin Erwei , Ji Bowen
Published: May 2023

The study of wearable systems based on surface electromyography (sEMG) signals has attracted widespread attention and plays an important role in human–computer interaction, physiological state monitoring, and other fields. Traditional sEMG signal acquisition systems are primarily targeted at body parts that are not in line with daily wearing habits, such as the arms, legs, and face. In addition, some systems rely on wired connections, which impacts their flexibility and user-friendliness. This paper presents a novel wrist-worn system with four sEMG acquisition channels and a high common-mode rejection ratio (CMRR) greater than 120 dB. The circuit has an overall gain of 2492 V/V and a bandwidth of 15~500 Hz. It is fabricated using flexible circuit technologies and is encapsulated in a soft skin-friendly silicone gel. The system acquires sEMG signals at a sampling rate of over 2000 Hz with a 16-bit resolution and transmits data to a smart device via low-power Bluetooth. Muscle fatigue detection and four-class gesture recognition experiments (accuracy greater than 95%) were conducted to validate its practicality. The system has potential applications in natural and intuitive human–computer interaction and physiological state monitoring.
A Novel NanoMIP–SPR Sensor for the Point-of-Care Diagnosis of Breast Cancer
Authors: Erol Kadir , Hasabnis Gauri , Altintas Zeynep
Published: May 2023

Simple, fast, selective, and reliable detection of human epidermal growth factor receptor 2 (HER2) is of utmost importance in the early diagnosis of breast cancer to prevent its high prevalence and mortality. Molecularly imprinted polymers (MIPs), also known as artificial antibodies, have recently been used as a specific tool in cancer diagnosis and therapy. In this study, a miniaturized surface plasmon resonance (SPR)-based sensor was developed using epitope-mediated HER2-nanoMIPs. The nanoMIP receptors were characterized using dynamic light scattering (DLS), zeta potential, Fourier-transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and fluorescent microscopy. The average size of the nanoMIPs was determined to be 67.5 ± 12.5 nm. The proposed novel SPR sensor provided superior selectivity to HER2 with a detection limit (LOD) of 11.6 pg mL−1 in human serum. The high specificity of the sensor was confirmed by cross-reactivity studies using P53, human serum albumin (HSA), transferrin, and glucose. The sensor preparation steps were successfully characterized by employing cyclic and square wave voltammetry. The nanoMIP–SPR sensor demonstrates great potential for use in the early diagnosis of breast cancer as a robust tool with high sensitivity, selectivity, and specificity.
Synthesis of Nano Pigments Using Clay Minerals and Organic Dyes and Their Application as Colorants in Polymer Matrix
Authors: Mohan Chandra , Kumari Neeraj , Jeandet Philippe , Kumari Priyanka , Negi Arvind
Published: May 2023

A new generation of clay-based nano pigments has been introduced, providing the advantage of both inorganic pigments and organic dyes. These nano pigments have been synthesized through a stepwise procedure where, initially, an organic dye is adsorbed onto the surface of the adsorbent, and then dye adsorbed adsorbent is used as pigment for further applications. The objective of the current paper was to examine the interaction of non-biodegradable toxic dyes, Crystal Violet (CV) and Indigo Carmine (IC), with clay minerals (montmorillonite (Mt), vermiculite (Vt), and clay bentonite (Bent)) and their organically modified forms (OMt, OBent, and OVt) and to develop a novel methodology for the synthesis of the value-added products and clay-based nano pigments without creating second generation waste materials. In our observation, the uptake of CV was more intense onto pristine Mt, Bent, and Vt, and the uptake of IC was more onto OMt, OBent, and OVt. CV was found to be in the interlayer region of Mt and Bent, as supported by XRD data. Zeta potential values confirmed the presence of CV on their surface. In contrast, in the case of Vt and organically modified forms, the dye was found on the surface, confirmed by XRD and zeta potential values. In the case of indigo carmine, the dye was found only on the surface of pristine Mt, Bent, Vt, and organo Mt, Bent, Vt. During the interaction of CV and IC with clay and organoclays, intense violet and blue-colored solid residues were obtained (also known as clay-based nano pigments). The nano pigments were used as colorants in a poly (methyl-methacrylate) (PMMA) polymer matrix to form transparent polymer films.
Advances in MXene-Based Electrochemical (Bio)Sensors for Neurotransmitter Detection
Authors: Yang Meiqing , Wang Lu , Lu Haozi , Dong Qizhi
Published: May 2023

Neurotransmitters are chemical messengers that play an important role in the nervous system’s control of the body’s physiological state and behaviour. Abnormal levels of neurotransmitters are closely associated with some mental disorders. Therefore, accurate analysis of neurotransmitters is of great clinical importance. Electrochemical sensors have shown bright application prospects in the detection of neurotransmitters. In recent years, MXene has been increasingly used to prepare electrode materials for fabricating electrochemical neurotransmitter sensors due to its excellent physicochemical properties. This paper systematically introduces the advances in MXene-based electrochemical (bio)sensors for the detection of neurotransmitters (including dopamine, serotonin, epinephrine, norepinephrine, tyrosine, NO, and H2S), with a focus on their strategies for improving the electrochemical properties of MXene-based electrode materials, and provides the current challenges and future prospects for MXene-based electrochemical neurotransmitter sensors.
Lateral Extensional Mode Piezoelectric ZnO-on-Nickel RF MEMS Resonators for Back-End-of-Line Integration
Authors: Zaman Adnan , Alsolami Abdulrahman , Wei Mian , Rivera Ivan , Baghelani Masoud , Wang Jing
Published: May 2023

High motional resistance and incompatibility with post-CMOS fabrication due to thermal budget constraints are imperative issues associated with the back-end-of-line integration of lateral extensional vibrating micromechanical resonators. This paper presents piezoelectric ZnO-on-nickel resonators as a viable means for mitigating both of the issues. Lateral extensional mode resonators equipped with thin-film piezoelectric transducers can exhibit much lower motional impedances than their capacitive counterparts due to piezo-transducers’ higher electromechanical coupling coefficients. Meanwhile, the employment of electroplated nickel as the structural material allows the process temperature to be kept lower than 300 °C, which is low enough for the post-CMOS resonator fabrication. In this work, various geometrical rectangular and square plates resonators are investigated. Moreover, parallel combination of several resonators into a mechanically coupled array was explored as a systematic approach to lower motional resistance from ~1 kΩs to 0.562 kΩs. Higher order modes were investigated for achieving higher resonance frequencies up to 1.57 GHz. Local annealing by Joule heating was also exploited for quality factor improvement after device fabrication by ~2× enhancement and breaking the record of MEMS electroplated nickel resonators in lowering insertion loss to ~10 dB.
The Influence of Fluid-Exsolving Depth on Mineralization Quality: Evidence from Biotite and Zircon Mineralogy and Fluid Inclusions from the 460 Gaodi Porphyry Mo-Cu Deposit, NE China
Authors: Kan Jing , Qin Kezhang , Wang Le , Hui Kaixuan , Han Ri
Published: May 2023

The recently discovered 460 Gaodi porphyry Mo-Cu deposit is a sub-economic deposit characterized by low Mo-Cu grades, dispersed mineralization, and separated Mo- and Cu-ore bodies. This study aims to elucidate the factors underlying this type of sub-economic mineralization. Electron-microprobe analyses of biotite from ore-related granite porphyry yielded Ti-in-biotite crystallization temperatures of 677–734 °C (an average of 719 °C) and biotite phenocryst crystallization depths of 6.0 to 12.9 km. LA-ICP-MS analyses of zircons from the same sample revealed average zircon Ce4+/Ce3+ ratios of 299.7 and elevated zircon lg(ƒO2) ratios, with an average ΔFMQ of +6.6 ± 1.9. These discoveries suggest that the magma responsible for ore formation boasts a high degree of oxidation, yet also possesses a magma chamber located at a significant depth within the upper crust. This implies an extensive exsolving depth for fluids. Furthermore, our microthermometry analysis of fluid inclusions reveals that a portion of the fluid experiences considerable conductive cooling as it ascends along the conduit, owing to the depth of fluid exsolution. This process results in the ore fluids remaining in the liquid-only region without undergoing boiling, which is conducive to the enrichment of metals. We emphasize the fact that fluid-exsolving depth plays a critical role in determining the metal grades and economic value of a porphyry deposit by regulating the P-T evolution path of the ore fluids
Pink to Purple Sapphires from Ilakaka, Madagascar: Insights to Separate Unheated from Heated Samples
Authors: Karampelas Stefanos , Hennebois Ugo , Mevellec Jean-Yves , Pardieu Vincent , Delaunay Aurélien , Fritsch Emmanuel
Published: May 2023

The present study is focused on the analysis of zircon inclusions found in pink to purple sapphires from Ilakaka (Madagascar) with an optical microscope, Fourier-transform infrared (FTIR), and micro-Raman spectroscopy in order to update previous knowledge and find insights to separate heated from unheated samples. In total, 157 zircon inclusions in 15 unheated samples and 74 zircon inclusions in 6 heated samples are analysed using micro-Raman spectroscopy with standardised parameters. The full width at half maximum (FWHM) of the main Raman band due to anti-symmetric stretching vibration ν3 of the SiO4 tetrahedron in the zircon structure has been carefully measured. In the unheated samples, it ranges from 6.26 to 21.73 cm−1 with an average of 10.74 cm−1, a median of 10.04 cm−1, and a standard deviation of 2.84 cm−1. On the other hand, it is lower in the heated samples, ranging from 4.83 to 14.97 cm−1 with an average of 7.23 cm−1, median of 7.06 cm−1, and standard deviation of 1.63 cm−1. In our unheated samples, the FWHM was rarely below 7 cm−1. In our heated samples, the FWHM was rarely above 12 cm−1 but mostly below 8 cm−1, with a variation restricted to less than 3 cm−1 in the same sample. The present work will hopefully further contribute to more accurately identifying the low-temperature heat treatment of pink sapphires from Ilakaka, Madagascar.