bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Pengelompokan Data Argumen Tentang Penerapan Kebijakan Sistem Zonasi Pada Pendaftaran Sekolah Dengan Menggunakan Metode Clustering
Authors: Ika Ika Pusvitaningrum
Published: January 2021

<a href="http://www.u-dictionary.com/home/word/The%20Indonesian%20government%20has%20taken%20steps%20to%20seek%20comprehensive%20reform%20of%20schools.%20One%20of%20the%20efforts%20of%20governments%20is%20to%20implement%20a%20zoning%20system,%20which,%20in%20this%20policy,%20governments%20have%20set%20boundaries%20-%20the%20limit%20of%20rayon%20to%20the%20region%20around%20schools,%20which,%20in%20turn,%20should%20be%20prioritized%20for%20new%20student%20registrations,%20those%20of%20which%20live%20closer%20to%20school.%20Beyond%20rayon%20or%20school%20district%20can%20register%20with%20the%20old%20person's%20accomplishments%20and%20transmigration%20pathways,%20which%20is%20a%20factor%20in%20the%20rise%20of%20controversy%20in%20society.%20By%20doing%20so,%20these%20studies%20can%20become%20a%20valid%20standard%20or%20standard%20for%20schools%20to%20prepare%20for%20the%20zoning%20system%20for%20the%20New%20Year.%20In%20this%20study%20the%20data%20used%20is%20the%20real%20data%20obtained%20from%20the%20dissemination%20of%20the%20questionnaire%20to%20society.%20The%20data%20gathered%20is%20380%20and%20181%20male%20respondents%20and%20199%20female%20respondents%20of%202%20district%20in%20pati,%20the%20margoyoso%20and%20tayu%20districts.%20Data%20is%20processed%20using%20version%201.%201,456%20r%20software,%20and%20it%20is%20thereafter%20done%20clustering%20by%20k-means./from/en/to/hi">The Indonesian government has taken steps to seek comprehensive reform of schools. One of the efforts of governments is to implement a zoning system, which, in this policy, governments have set boundaries - the limit of rayon to the region around schools, which, in turn, should be prioritized for new student registrations, those of which live closer to school. Beyond rayon or school district can register with the old person's accomplishments and transmigration pathways, which is a factor in the rise of controversy in society. By doing so, these studies can become a valid standard or standard for schools to prepare for the zoning system for the New Year. In this study the data used is the real data obtained from the dissemination of the questionnaire to society. The data gathered is 380 and 181 male respondents and 199 female respondents of 2 district in pati, the margoyoso and tayu districts. Data is processed using version 1. 1,456 r software, and it is thereafter done clustering by k-means.
Pengaruh Komunikasi Interpersonal Orang Tua-Anak Terhadap Agresi Siswa Kepada Guru
Authors: Issom Fitri Lestari , Damayanti Febi
Published: January 2021

This research was conducted to find out the influence of parent-children interpersonal communication on student aggression to the teacher. This research used quantitative research method and the data are processed by using the regression analysis method. The population of this research are adolescent who studied in junior high school, senior high school, and vocational high school. The sample of this research are 360 students from junior high school, senior high school, and vocational high school in Central Jakarta. The instrument of this research is “The Aggression Questionnaire” which has been modified to devoted measuring student aggression to the teacher. Then, using the interpersonal communication scale to measure parent-children interpersonal communication. The result of this research shows that there are 4.4% of negative influence of interpersonal communication on students aggression to the teacher. It means that the more parent-children interpersonal communication happens, the more student aggression to the teacher decreases, and vice versa.

 

Keyword: interpersonal communication, aggression, students.
Hubungan Antara Dark Triad Personality dan Kecenderungan Korupsi Karyawan
Authors: Limanago Yuci
Published: January 2021

Kecenderungan korupsi karyawan dipengaruhi oleh beberapa faktor baik internal maupun eksternal. Salah satu faktor internal tersebut adalah kepribadian dan fokusnya yang diteliti pada penelitian ini adalah Dark Triad Personality. Penelitian ini dilakukan pada karyawan PT. SGI (perusahaan swasta nasional) yang khususnya bekerja di area Jawa Timur. Jumlah subjek penelitian ini adalah 215 orang. Seluruh subjek telah bekerja di PT. SGI minimal 1 tahun mulai dari level operator/ administrasi sampai manager dengan rentang usia mulai  22-55 Tahun. Hasil analisis regresi menunjukkan ada hubungan yang signifikan antara dark triad personality dan kecenderungan korupsi karyawan (p = 0,032; r = 0, 147). Implikasi praktis dari penelitian ini adalah adanya upaya yang harus dilakukan oleh manajemen perusahaan agar senantiasa berusaha melakukan seleksi kepribadian karyawan untuk mengurangi kecenderungan korupsi di antara karyawan yang bekerja di perusahaan tersebut.
Validasi Skala Sikap Terhadap Pelajaran Matematika dan Sains
Authors: Periantalo Jelpa , Andhika Rahman Marlita , Wahyuni Hera , Fadzlul Fadzlul
Published: January 2021

Penelitian bertujuan melakukan validasi Skala Sikap terhadap Pelajaran Matematika dan Sains dengan kriteria variabel lain. Pelajaran terdiri Matematika, Fisika, Kimia dan Biologi. Kriteria  berupa Tes Potensi Akademik Universitas Jambi, Minat Ilmu Kesehatan - Tes  Minat Indonesia, dan Nilai Ujian Nasional. Subjek penelitian, mahasiswa baru Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi berjumlah N=549. Terdapat hubungan positif TPA dengan Matematika рxy=0.238; Kimia рxy=0.2000 dan Biologi рxy=0.163 serta tidak ada hubungan dengan Fisika рxy=-0.044 (p<0,01; N=549). Terdapat hubungan positif  Minat Ilmu Kesehatan dengan Biologi рxy=0.173 dan Kimia рxy=0.148.  Terdapat hubungan positif nilai Ujian Sekolah pada pelajaran Matematika рxy=0.373 dan Kimia рxy=0.235. Alat ukur maupun data penelitian dapat digunakan untuk bahan pembelajaran, validasi alat ukur lain, evaluasi pembelajaran, peminatan SMA maupun penjurusan kuliah. Penelitian berikutnya melakukan validasi  dengan nilai ujian nasional dengan subjek lebih luas dan IPK mahasiswa demi mencapai pengukuran yang kuat.
Pengaruh Kepribadian Lima Besar Terhadap Intensi Berwirausaha Pada Mahasiswa Psikologi Universitas Negeri Jakarta
Authors: Erik Erik
Published: January 2021

Terdapat beberapa faktor yang dapat memengaruhi seseorang untuk menjadi seorang pengusaha. Salah satunya yaitu faktor kepribadian. Tujuan penelitian ini yaitu ingin mengetahui pengaruh kepribadain lima besar terhadap intensi berwirausaha pada mahasiswa psikologi Universitas Negeri Jakarta. Metodologi yang digunakan dalam penelitian ini yaitu kuantitatif dengan menggunakan analisis regresi. Sampel dalam penelitian ini adalah 136 mahasiswa psikologi universitas negeri Jakarta tingkat akhir. Instrumen yang digunakan dalam penelitian ini yaitu instrumen intensi berwirausaha yang diadaptasi dalam bahasa Indonesia dan instrumen Big Five Inventory Scale versi Indonesia. Hasil penelitian menunjukkan bahwa terdapat pengaruh dimensi kepribadian agreeableness terhadap intensi berwirausaha. Nilai koefisien (Adjusted R square) sebesar 0,058. Artinya dimensi-dimensi kepribadian lima besar memberikan kontribusi sebesar 5,8% terhadap intensi berwirausaha.
Adopting Indonesian Folklore as an Instructional Media Through Cards Games
Authors: Komang Redy Winatha  , Ni Putu Suci Meinarni  , Ayu Gede Willdahlia
Published: January 2021

Psychologically, humans tend to love games compared to learning. Therefore, learning should be delivered through fun ways and not boring just like a game. This research aims to develop card games as learning media of Interpersonal Skill Course at STMIK STIKOM Indonesia. This course was chosen based on the availability of minimum teaching materials, the level of material abstractness which is high enough, and there is still no innovative learning that can support the learning. Beside easing the students in comprehending the materials of Interpersonal Skill through fun ways, this card game at once also reminds the students about deep philosophy contained in Indonesian folklores. The chosen folklores cover the stories developing and frequently told in the society such as Timun Emas, Malin Kundang, and so on. The research design used research and development method referring to ADDIE model which is limited until the developing stage. The result of this research is learning media the card game which is an innovation in learning process replacing conventional learning. Based on the results of expert test conducted, the learning media in the form of card games adopting Indonesian folklores is valid and successfully developed.
Increasing HOTS of High School Students Using Mobile Technology and Scaffolding Approach: Study on Physics Learning
Authors: Aji Singgih Hutomo , Suparno
Published: January 2021

Improvement, development, and growth of a country cannot be separated from the quality of its human resources. This is even more so for a country that will face a population demographic bonus like Indonesia, which requires excellent and increasing quality of human resources so that they are always able to compete. Education is one of the factors that plays an important role in advancing the quality of human resources. This study aims to develop an Android-based learning media application on simple harmonic motion physics material and is used to improve the HOTS ability of students by learning using the scaffolding approach. This study is an R&D with a 4D model consisting of the Defining, Designing, Developing, and Disseminating stages. The operational test at the Developing stage was carried out using an experiment with the Pretest-Posttest Control Group design. The product in this study is an Android-based physics learning media application on simple harmonic motion material that has been tested for its feasibility for use in physics learning. Then, the product was tested in the field by being implemented in learning. The experimental results in the experimental class using android media and the scaffolding approach and the control class using conventional learning showed a significant difference in HOTS abilities. The implementation of Android-based physics mobile learning media and the scaffolding learning approach has a positive effect on the HOTS ability of students.
Some biological characteristics of the smooth blaasop puffer fish Lagocephalus inermis (Temminck and Schlegel, 1850), from south-eastern Arabian Sea
Authors: Saha Purbali , Thomas Sujitha
Published: January 2021

Length-weight relationship (LWR), condition factor, sex ratio, gonadosomatic index (GSI) hepatosomatic index (HSI) of the smooth blaasop puffer fish Lagocephalus inermis (Temminck and Schlegel, 1850), an emerging fishery resource along south-eastern Arabian Sea were studied from 1,722 samples collected during August 2017-May 2019 from Mangalore Fishing Harbour, Karnataka, India. LWR indicated negative allometric growth [W = 0.034805L2.76 (males); W = 0.033574L2.78 (females), W = 0.033979L2.77 (pooled)] and significant difference was observed in the b value of the fishes. Sex ratio was 1:1.08. The ratio was unusually high during post-monsoon and Chi-square test revealed that the monthly sex ratio did not vary significantly throughout the year except for December and January (p<0.01). Condition factor (K) and relative condition factor (Kn ) also were not significantly different between sexes. Two peak spawning seasons were identified - NovemberFebruary and August. The GSI was highest in August (female = 8.08 and male = 5.82) and lowest in May (female = 3.32 and male = 3.49). The HSI value was found to be inversely related to GSI and was highest in May (5.21) and lowest in August (3.99). These parameters are essential pre-requisites for stock assessment and sustainable management of the fishery resource.
: Demonstration of Acoustic Sensing Techniques for Fuel-Distribution System Condition Monitoring : Final Report on Project F07-AR07
Authors: McInerney Michael K. , Carlyle John M.
Published: January 2021

Leaks in fuel storage tanks and distribution piping systems have been identified as a mission-critical problem by the Department of Defense and the U.S. Army. Fuel system leaks are often hard to locate and virtually inaccessible for efficient repair because the piping is often installed under a concrete pad or tarmac. Leak repair could cost up to $2,000, and the cost of cleanup and re-mediation for fuel spills can exceed $50,000. In this project an acoustic remote sensing system was installed to monitor an Army heliport refueling system to determine whether it could detect and accurately locate fuel leaks using computer software technolo-gies to distinguish acoustic leakage signatures from normal fuel system operational noise. Demonstration and validation efforts were disadvantaged by the fact that no fuel leaks occurred in the monitored system for the duration of the project. However, the monitoring system did identify several unusual acoustic events within the fueling system and interpret them as indications of intermittent malfunctions of a check valve and a fuel pump. The 30-year ROI is about 6.42. Further work is required before the technology can be fully implemented: its ability to detect fluid leaks must be proven, and the system specifications must be certified through an EPA third party.
Why we missed it? Computational analysis reveals distribution patterns of Malassezia furfur, the etiological agent of Pityriasis versicolor, in skin metagenomes
Authors: Abdelaziz Mohamed Taha , Hassan Mariam , Damasy Dalia Ali El , Aziz Ramy Karam
Published: January 2021

Malassezia furfur is the main causative species in pityriasis versicolor infections and is now widely believed to be a part of the skin microbiota, yet it was systematically missed in the early skin metagenomic studies. Here, we curated a specific set of M. furfur sequences and used them to reanalyze publicly available skin metagenomes to computationally investigate the distribution of M. furfur and its relative abundance at different skin sites. To this end, we used BLASTN to match and align these marker genes to the selected metagenomic datasets and estimated M. furfur relative abundance as the number of BLASTN hits per million metagenomic reads. We found a relative enrichment of M. furfur in the retro auricular crease, the antecubital fossa, and the forehead. Among skin categories, sebaceous areas were the most significantly enriched in M. furfur, while in terms of exposure/occlusion, exposed areas had the highest abundance. This work will facilitate and allow the estimation and correction of past estimates of this important fungal species in shot gun metagenomic data sets.
Energy-Efficient Smart Window Based on Thermochromic Hydrogel with Ultrahigh Visible Transparency and Unprecedented Infrared Transmittance Modulation
Authors: Zhang Rong , Xiang Bo , Feng Min , Xia Liru , Xu Lei , Tang Shaochun , Guan Qingbao
Published: January 2021

Both high visible transparency and strong solar modulating ability are highly required for energy-saving smart windows, but conventional responsive materials usually have low transparency and narrow solar transmittance range. Herein, we report a significant advance toward the design and fabrication of responsive smart windows by trapping novel V0.8W0.2O2@SiO2 doped poly(N-isopropyl acrylamide) (PNIPAm) thermochromic liquid hydrogel within two glass panels. The smart window is highly transparent to allow solar transmittance at low temperatures, while turns opaque automatically to cut off solar energy gain when exposed in sunlight. With a remarkably low content (1.0wt‰) of dopant, V0.8W0.2O2@SiO2/PNIPAm (VSP) hydrogels exhibit ultrahigh luminous transmittance Tlum of 92.48% and solar modulation ∆Tsol of 77.20%. The superior performance is mainly attributed to that V0.8W0.2O2@SiO2 doping induces PNIPAm particles’ size reduction and internal structure change. W-doping decreases the phase transition temperature (Tc) of VO2 from 68 ºC to ~30 ºC (close to the Tc of PNIPAm), contributing to an unprecedented infrared transmittance modulation. Especially, the smart window shows excellent energy-saving during daytime outdoor demonstrations where practically achievable cooling temperature reaches up to 15.1 ºC. In addition, the smart window exhibits outstanding stability, as embodied by unchanged optical performance even after 100 transparency-opaqueness reversible cycles. This new type of thermochromic hydrogel offering unique advantages of shape-independence, scalability together with soundproof functionality promises potential applications in energy-saving buildings and greenhouses.
Attitude of Medical Students Towards Neurology, Faculty of Medicine, University of Khartoum 2019: A Cross-Sectional Study.
Authors: Mohammed Abdelhaleem , Musa Muneer
Published: January 2021

Background: Medical students have unfavorable attitude towards Neurology and often perceive it as the most difficult medical specialty. This perception is described as " neurophobia " in the medical literature and its effects and potential solutions are being investigated in many countries around the world.Methods: A cross sectional study was conducted in which a questionnaire was administered to a sample of third, fourth, fifth and sixth years’ medical students at Faculty of Medicine, University of Khartoum. The sample size was 310 selected through stratified, systematic random sampling technique. In this study, the questionnaire includes the following aspects: demographic data, assessment of the level of interest in Neurology as a future career, evaluating the satisfaction with the neurosciences course, identifying the factors which affect the attitude of students towards Neurology, highlighting the most useful strategies in teaching Neurology.Results: Females constituted 71% of the respondents. 37.4% of the students had little or no interest and only 9.4% were strongly interested in Neurology.46.8% of the students graded their satisfaction with the course as neutral (i.e.: moderate) and 30.6% were unsatisfied with the delivered course (6.8% of them were strongly unsatisfied). Limited exposure to neurological patients and separation of basic sciences teaching from clinical application were considered as the top contributing factors to formation of this negative perception towards Neurology. Increased exposure to neurological patients, three dimensional simulators, video recordings, online resources as well as improving teaching skills of the lecturers were labeled as the most fruitful strategies to make progress in Neurology teaching.Conclusion: This study reveals that 'neurophobia' probably affects a considerable proportion of medical students in Khartoum University. It reflects the possible contributing factors; Besides It encourages the stakeholders to modify the current approach to neuroscience and neurology education, and in this regard, it puts forward several strategies to make an evolution in this arena.
Prospects of Ocimum Gratissimum Linn. (Lamiaceae) to Control Exorista SorbillansWiedemann (Diptera: Tachinidae) Menace of Silkworm in Seriecosystem
Authors: Khanikor Bulbuli , Bora Dipsikha
Published: January 2021

Tachinid parasitoids are in focus mostly as biocontrol agents to be released against lepidopteran pest. But surprisingly certain tachinid parasitoids attack economically beneficial insects like silkworm and demands control measures against them. The uzi fly Exoristasorbillans (Diptera: Tachinidae) infests all commercially important silkworm species including Antheraeaassamensis where it causes upto 80 percent crop loss. The control of such parasitoids is a difficult task as the larval stage is endoparasitic and chemical insecticides do not reach the targeted parasitoid without exposing the silkworm host.In the present study,we evaluated adulticidal activity of different solvent extracts and essential oil of Ocimumgratissimum. We found higher efficacy of essential oil in comparison to other solvent extracts. The effective fraction of oil was found to contain thymol or its isomer carvacrol as the major compound in GC-MS studies. Finally, O. gratissimum oil-based combination (MI) and carvacrol based combination of essential oil compounds (MII) were prepared, tested and found to be effective against the fly. In silico positive interaction of essential oil compounds with acetylcholinesterase enzyme model of the fly revealed that the said enzyme is one of the target proteins for these oil compounds to interrupt its function and subsequent lethal action.
Trends in relevant excess mortality in Peru and nine areas during the first wave of COVID-19 pandemic between January and May 2020: A descriptive study
Authors: Diego Juan , Enrique Josè
Published: January 2021

Introduction: COVID-19 has arrived the main capitals of Peru and caused direct and indirect deaths. Though mortality data is reported through SINADEF, relevant excess mortality (REM) remains unknown.Objective: To estimate the monthly relevant excess mortality for all causes and non-related with violent and COVID-19 causes between January and May 2020 in Peru and nine areas with the highest absolute numbers of deaths by COVID-19. Material and Methods: To estimate relevant excess mortality, we calculated the monthly upper and lower limits of historical mortality (95% confidence interval) and the average for the last 3 years (2017-2019). REM was considered when observed values exceed the estimated upper limit plus corresponding 2 standard deviations. We also determined REM excluding non-related with violent and COVID-19 causes.Findings: Relevant excess mortality of 35 deaths per 100 000 population from all causes during April and May 2020 were found in Peru with no difference when we excluded violent deaths. In addition, Callao had the highest REM followed by Lima, Ucayali, Loreto, Piura, Ica, Ancash, and La Libertad. In country and capitals analysis, male and individuals over 60 years were the most affected groups.Discussion: Relevant excess mortality determination is a needed, easy and low-cost approach to monitor the progress of COVID pandemic and to evaluate the effectiveness of policy measures. This surveillance method should expand to the 25 locations of Peru. Conclusion: COVID-19 accounted for 45% of the relevant excess all-cause deaths, leaving 54.29% unattributed to COVID-19. Hence, it is necessary to rethink the policy measures in order to avoid direct and indirect deaths attributed to the pandemic.
Prevalence, Cognitive Characteristics and Influence Factors of Amnestic Mild Cognitive Impairment among Community-dwelling Older Adults in Chengdu, China
Authors: Qiu Peiyuan , Cai Yan , Wang Yangyang , Liao Shiyi , Nie Yunbo , Wang Ye , Rao Shan , Kuang Weihong
Published: January 2021

Background: Dementia is a global public health priority. Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia. And amnestic MCI (aMCI) is proved to have a higher probability to develop into AD comparing to other type of MCI. Yet a few studies have focused on prevalence of aMCI in China. This study aims to explore the prevalence of amnestic mild cognitive impairment (aMCI), cognitive characteristics of aMCI, and associated risk factors for aMCI.Methods: A cross-sectional study was conducted in the communities of Chengdu, China. Participants were 368 older adults aged 60 years and over. Participants completed various neuropsychological assessments, including the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating (CDR), Auditory Verbal Learning Test (AVLT), Wechsler’s Logical Memory Task (LMT), Boston Naming Test (BNT) and Trail Making Test Part A (TMT-A). Social information was collected by standard questionnaire. Multiple logistic regression analysis was utilized to screen for the risk and protective factors of aMCI.Results: Data included 309 subjects with normal cognitive function and 59 with aMCI. The prevalence of aMCI was 16.0%.The average age of participants was 69.06±7.30 years, with 56.0% being females. After controlling for age, gender and education, the Spearman partial correlation coefficient between diverse cognitive assessments and aMCI ranged from -0.52 for the long-term delayed recall scores in AVLT to 0.19 for the time-usage scores in TMT-A, and results revealed that all domains except naming scores (after semantic cue of BNT) and error quantity (in TMT-A) showed statistically significant associations with aMCI. And the results of multiple logistic regression analysis indicated that older age (OR=1.044, 95%CI: 1.002~1.087, p=0.042), lower educational level, and diabetes (OR=2.450, 95%CI: 1.246~4.818, p=0.009) were risk factors of aMCI.Conclusions: Participants with aMCI showed lower cognitive function in memory, language and executive domains, especially in long-term delayed recall. The participants who were older, had less education, or with diabetes had higher risk of suffering from aMCI. These results may help clinical practitioners design and conduct targeted cognitive training and chronic disease management for the elderly, aiming to prevent and delay development of Alzheimer’s dementia.
Sleeping During the First Wave: Demographic, Psychological, Chronobiological, and Work-Related Predictors of Sleep Disturbances Throughout the COVID-19 Lockdown
Authors: Salfi Federico , Lauriola Marco , D'Atri Aurora , Amicucci Giulia , Viselli Lorenzo , Tempesta Daniela , Ferrara Michele
Published: January 2021

The first COVID-19 contagion wave caused unprecedented restraining measures worldwide. In Italy, a period of generalized lockdown involving home confinement of the entire population was imposed for almost two months (9 March–3 May 2020). The present is the most extensive investigation aimed to unravel the demographic, psychological, chronobiological, and work-related predictors of sleep disturbances throughout the pandemic emergency. A total of 13989 Italians completed a web-based survey during the confinement period (25 March–3 May). We collected demographic and lockdown-related work changes information, and we evaluated sleep quality, insomnia and depression symptoms, chronotype, perceived stress, and anxiety using validated questionnaires. The majority of the respondents reported a negative impact of confinement on their sleep and a delayed sleep phase. We highlighted an alarming prevalence of sleep disturbances during the lockdown. Main predictors of sleep disturbances identified by regression models were: female gender, advanced age, being a healthcare worker, living in southern Italy, confinement duration, and a higher level of depression, stress, and anxiety. The circadian evening preference turned out as a vulnerability factor, while morning-type individuals showed a lower predisposition to sleep and psychological problems. Finally, working from home emerged as a protective factor against the development of sleep disturbances. Besides confirming the role of specific demographic and psychological factors in developing sleep disorders during the COVID-19 pandemic, we demonstrated circadian typologies react differently to a particular period of reduced social jetlag. Finally, our results indicated working from home promotes well-being during the current pandemic period.
Community Case Managers’ (CCMs) Perspectives’ Collaborating With Primary Care Services When Managing Complex Patients in the Community: A Qualitative Study.
Authors: Yeo Gilbert , Kannan Predeebha , Lee Eng Sing , Smith Helen
Published: January 2021

Background: Strong collaboration between community case managers (CCMs) and medical professionals are vital for the continuity of complex patients’ care in the community. Key challenges can influence or even deter successful collaboration. Objective: The objective of this qualitative study was to understand the challenges encountered by CCMs when collaborating with primary care services. Methods: This exploratory qualitative descriptive study used individual in-depth interviews. CCMs were selected using maximum variation and snowball sampling. The interviews were semi-structured, guided by a topic guide. Data were analyzed alongside ongoing data collection. Thematic content analysis was used to analyze the transcripts. Initial codes were obtained independently. These codes were then further explored, clarified and iteratively grouped into themes.Results: Fourteen individual in-depth interviews were conducted. Six themes emerged from the data i.e. self-identity, patient factor, inter-professional factor, collaborative culture, confidentiality and organizational structure. Challenges that resonated with previous studies were self-identity, inter-professional factors and confidentiality, whereas other challenges such as patient factors, collaborative culture, and organizational structure, were unique to Singapore’s health care landscape.Conclusions: Significant challenges were encountered by CCMs when collaborating with primary care services. Understanding these challenges is key to refining intervention in current models of comprehensive community care between medical and non-medical professionals.
Identifying Prognostic Lncrnas Based on A ceRNA Regulatory Network in Laryngeal Squamous Cell Carcinoma
Authors: Shi Yong , Yang Dongli , Qin Yixiao
Published: January 2021

Purpose Growing evidence demonstrates that long non-coding RNAs (lncRNAs) play a crucial role as competing endogenous RNAs (ceRNAs) in tumor occurrence. The lncRNAs' function and clinical significance in laryngeal squamous cell carcinoma (LSCC) remain unclear. The study aims to reveal the lncRNA-associated ceRNA regulatory network in LSCC and clarify its clinical relevance.Methods Here, we obtained LSCC transcriptome sequencing data from The Cancer Genome Atlas (TCGA) database and identified the differential expression profile of lncRNAs, miRNAs, and mRNAs by the EdgeR R package. The function enrichment analysis of mRNAs was performed using clusterProfiler R package and GSEA3.0. Then, we constructed a ceRNA network and a prognosis model based on lncRNAs through bioinformatic methods. Moreover, we explored the functions of prognosis-related lncRNA in LSCC by CCK-8 and transwell assay. Results 1961 lncRNAs, 69 miRNAs, and 2224 mRNAs were identified as differentially expressed genes in LSCC tissues. According to the transcriptome differential expression profile, a ceRNA network containing 61 lncRNAs, 21 miRNAs, and 77 mRNAs was established. Then, four lncRNAs (AC011933.2, FAM30A, LINC02086, LINC02575) were extracted from the ceRNA network to build a prognosis model for LSCC patients. Furthermore, we found that LINC02086 and LINC02575 promoted the proliferation, migration, and invasion of LSCC cells while AC011933.2 and FAM30A inhibited these biological functions in vitro. Conclusion Four lncRNAs from the ceRNA network were abnormally expressed and related to patient prognosis in LSCC. They played a significant role in the progress of LSCC via affecting the proliferation and metastasis of tumor cells.
Employment of Patients With Kidney Failure Treated With Dialysis or Kidney Transplantation - A Systematic Review and Meta-Analysis
Authors: Kirkeskov Lilli , Carlsen Rasmus , Lund Thomas , Buus Niels-Henrik
Published: January 2021

Background: Patients with kidney failure treated with dialysis or kidney transplantation experience difficulties maintaining employ­­ment due to the condition itself as well as the treatment. We aimed to establish the rate of employment before and after initiation of dialysis and after kidney transplantation and to identify predictors of employment during dialysis and post-transplant.Methods: This systematic review and meta-analysis was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis, PRISMA, for studies that included employment rate in adults receiving dialysis or a kidney transplant. The literature search included cross sectional or cohort studies published in English in the period from January 1966 to August 2020 in the databases PubMed, Embase, and Cochrane Library. Data of employment rate, study population, age, gender, educational level, dialysis duration, kidney donor, ethnicity, dialysis modality, waiting time for transplantation, diabetes, and depression were extracted. Quality assessment was performed using the Newcastle-Ottawa Scale. Meta-analysis for predictors for employment and odds ratio; confidence intervals; and test for heterogeneity were calculated using Chi-squared statistics and I2. PROSPERO registration number: CRD42020188853.Results. 33 studies with 162,059 participants during dialysis and 31 studies with 137,742 participants receiving kidney transplantation. Dialysis patients were on average 52.6 years old (range 16-79), 60.3% males and kidney transplant patients 46.7 years old (range 18-78), 59.8% males. The employment rate (weighted mean) for dialysis patients was 26.3% (range 10.5-59.7%); pre-transplant 36.9% (range 25-86%), and post-transplant 38.2% (range 14.2-85%). Predictors for employment during dialysis and post-transplant were male, non-diabetic, peritoneal dialysis, and higher educational level, and post-transplant: pre-transplant employment, younger age, transplantation with a living donor kidney, and without depression.Conclusions: Patients with kidney failure had a low employment rate during dialysis, pre- and post-transplant. Kidney failure patients should be supported through a combination of clinical and social measures to ensure they remain in work.
Modeling Preconception Perceptions of Pregnancy and Birth: A Qualitative Study of Women Living in Italy
Authors: Rivera Sydney , Meier Stephanie , Naoum Zeina , DeMaria Andrea
Published: January 2021

Background: Preconception health planning is a recognized resource for optimization of physical and mental-emotional health prior to pregnancy, though few women and providers demonstrate high awareness of preconception health. Furthermore, concerns, fear, and risk perceptions are often absent from the discussion, despite their potential impact on pregnancy and birth decision-making. These themes remain understudied in Italian populations. Methods: Researchers conducted in-depth interviews in 2017 with 43 reproductive-aged women living in or around Florence, Italy, and currently using the Italian health care system. An expanded grounded theory approach was used to explore pregnancy and birth perceptions. HyperRESEARCH facilitated open and axial coding for thematic analyses.Results: Themes emerged in the form of three continuous spectrums across which women view pregnancy and birth decision-making in the preconception period. First, participants identified strong social and healthcare support for pregnancy and birth, which at times was perceived as excessive or limiting (Supported vs. Controlled). Second, participants contrasted Italian preferences for natural and holistic processes with the medical model of prenatal care and birth (Natural vs. Medical). Third, participants constructed pregnancy and birth through risk narratives, placing a high priority on safety (Safe vs. Risky). While women described a culture of social support and natural lifestyle preferences, they also emphasized complications and risk, treatment of pregnant women as sick or fragile, seemingly rigorous prenatal care, and birth choices contingent on as-of-yet unexperienced complications. High levels of social and medical control surrounding pregnancy correlated with high levels of perceived risk. Conclusions: Findings offer opportunities for practitioners to address pregnancy- and birth-related concerns and misinformation through an integrated model demonstrating both the destructive role of risk and control as well as the possibility of a more positive emphasis on safety and support.
Network Analysis Indicating the Pharmacological Mechanism of Yunpi-Qufeng- Chushi-Prescription in Prophylactic Treatment of Rheumatoid Arthritis
Authors: Li Lin , Zhou Donghai , Liu Qiuping , Li Dianming , Wang Qiao , Shi Xiaowei , Wen Chengping , Huang Lin
Published: January 2021

Background: Rheumatoid arthritis (RA), is an autoimmune inflammatory disease with increasing global morbidity and high disability. Early treatment is an effective intervention to slow down joint deformation. However, as for early RA and pre-RA patients, it sometimes takes a long time to make a definite diagnosis and few guidelines have made suggestion for these suspected or early phrase individuals. Yunpi-Qufeng-Chushi-Prescription (YQCP) is an optimization of the traditional formula, Cangzhu Fangfeng Tang which is effective for arthromyodynia management. Methods: In this study, LC-MS identify the main component of YQCP. Ingredients of the 11 herbs were collected from Traditional Chinese Medicine Integrated Database (TCMID). Targets of these ingredients were collected from two source, TCMID and PharmMapper. Microarray of 20 early untreated RA patients and corresponding health control were download from NCBI Gene Expression Omnibus (GEO) database to defined the differential expressed genes.Gene ontology analysis and KEGG enrichment analysis were carried out for the YQCP. Protein-protein interactions (PPIs) networks were constructed to identify the hub 2 / 13 2 targets. At last, molecular docking (MD) were conducted to further verified the the possibility of YQCP for RA therapy.Result: The study indicated that by acting on hub targets such as C3, EGFR, SRC and MMP9, YQCP may influence the mature of B cells and inhibit B cell-related IgG production, regulate oxidative stress and modulate activity of several enzymes including peroxidase and metallopeptidase to delay the occurrence and progress of RA and benefit the pre-RA or early RA patients. Conclusion: YQCP is a potential effective therapy for prophylactic treatment of RA.
Digital Dynamic Discrimination of Primary Colorectal Cancer Using Systemic Indocyanine Green with Near-Infrared Endoscopy.
Authors: Dalli Jeffrey , Loughman Eamon , Hardy Niall , Sarkar Anwesha , Khan Faraz , Khokhar Haseeb , Huxel Paul , O’Shea Donal , Cahill Ronan
Published: January 2021

Introduction: As indocyanine green (ICG) with near-infrared (NIR) endoscopy enhances real-time intraoperative tissue microperfusion appreciation, it may also dynamically reveal neoplasia distinctively from normal tissue especially with video software fluorescence analysis.Methods: Colorectal tumours of patients were imaged mucosally following ICG administration (0.25 mg/kg i.v.) using an endo-laparoscopic NIR system (PINPOINT Endoscopic Fluorescence System, Stryker) including immediate, continuous in situ visualization of rectal lesions transanally for up to 20 minutes. Spot and dynamic temporal fluorescence intensities (FI) were quantified using ImageJ (including videos at one frame per second, fps) and by a bespoke MATLAB® application that provided digitalized video tracking and signal logging at 30fps (Fluorescence Tracker App, FTA, downloadable via MATLAB® file exchange). Statistical analysis of FI-time plots compared tumours (benign and malignant) against control during FI curve rise, peak and decline from apex. Results: Early kinetic FI signal measurement (n=20, 16 males, 9 cancers) delineated discriminative temporal signatures from tumours offering rich data for analysis versus delayed spot measurement (n=10 patients with cancer). Malignant lesion curves peaked significantly later with a shallower gradient than normal tissue while benign lesions showed significantly greater and faster intensity drop from apex versus cancer. Automated tracker quantification efficiently expanded manual results and provided algorithmic KNN clustering. Conclusions Analysis of a continuous stream of intraoperatively acquired early ICG fluorescence data can act as an in situ tumour-identifier with greater detail than later snapshot observation alone. Software quantification of such kinetic signatures may distinguish invasive from non-invasive neoplasia with potential for real-time in silico diagnosis.
Modification of Densification Mechanisms By The Timing of Mechanical Pressure During Spark Plasma Sintering
Authors: Salamon David , Tan Hua , Zhang Haibo
Published: January 2021

The application of mechanical pressure during a sintering process is connected with grains sliding and diffusion enhancement. However, the timing of mechanical pressure during the rapid sintering process was not addressed. In the present study, four different timings of mechanical pressure with final pressure 50 MPa starting from the beginning, 600 ℃, 900 ℃ and at sintering temperature, furthermore one pressure-less SPS have been studied during SPS of Nano-Alumina powder (Taimei, Japan) at 1100 ℃, 1150 ℃, 1200 ℃, and 1300 ℃, respectively. The density, hardness, microstructure, and grain size of each sample were measured and calculated carefully. The results show that applying the pressure at 900 ℃ brings high density and small grain size, leading to the best Vickers hardness. The interaction between pressure and vapor, leading to the different vapor transfer rate of the first sintering stage, is considered as a reason for the differences in the microstructure.
Efficacy of Using a Laser Device to Reduce Wild (Water)Birds Visits to the Free-range area of a Layer Farm Situated in an Avian Influenza Hotspot-region in the Netherlands
Authors: Elbers Armin , Gonzales Jose
Published: January 2021

Free-range layer farms have a significantly higher risk of introduction of avian influenza viruses (AIV) compared to indoor layer farms. Wild water birds, natural reservoir of AIV, likely play a role in the transmission of AIV to chickens by contaminating the farms’ free-range area. The use of a laser as a repellent device for wild birds has been studied since the 1970s, in particular around airfields as bird-strike prevention, but its use at poultry farms to keep wild birds away from the surroundings of the poultry barn has not been studied. Part (1.5 ha) of the free-range area of a layer farm that directly boarded the poultry barn was equipped with a video-camera recording system. Visits of wild birds to this free-range study area were recorded for a month without and subsequently a month with a Class-III B laser in operation in the winter period. The laser was operated in the free-range study area between 5:00 PM and 10:00 AM, chickens were present in the free-range study area between 10:00 AM and 5:00 PM. The laser was operated in surrounding grass pastures between 10:00 AM and 5:00 PM. Mallards (Anas platyrhynchos) and Western barn owls (Tyto alba) visited the free-range study area between sunset and sunrise; Blackbirds (Turdus merula), Western yellow wagtails (Motacilla flava), White wagtails (Motacilla alba), Common Moor-hen (Gallimula chloropus) and Common kestrels (Falco tinnunculus) visited the free-range study area between sunrise and 10:00 AM. The overall (all bird species) efficacy of the laser for reducing the rate of wild birds visiting the free-range study area was 98.2 %. This efficacy was for birds of the Order Anseriformes 99.7 % and for birds of the Order Passeriformes 96.1 %. The overall exposure time of the free-range study area to wild birds (all species) was 617 times lower with the laser in operation compared to a situation in which the laser was not in operation. Exposure time to wild birds of the Order Anseriformes – known as bird flu risk species - was 2,320 times lower compared to the situation without the laser in operation. Summarizing, it can be concluded that the laser equipment used in this study was highly proficient in keeping wild birds – in particular wild ducks - away from the free-range study area of the layer farm.
Prediction of Blood Pressure Change During Surgical Incision Under Opioid Analgesia Using a New Opioid Sensitivity Index: A Cross-Sectional Study
Authors: Kamiya Satoshi , Nakamura Ryuji , Saeki Noboru , Kondo Takashi , Miyoshi Hirotsugu , Narasaki Soushi , Morio Atsushi , Kawamoto Masashi , Hirano Harutoyo , Tsuji Toshio , Tsutsumi Yasuo
Published: January 2021

Opioid inhibition of nociceptive stimuli varies in individuals and is difficult to titrate. We have reported the vascular stiffness value (K) as a standard monitor to quantify sympathetic response with high accuracy. On the contrary, among individuals, a considerable variation in the rate of change in K for constant pain has been observed. In this study, we proposed a new index, minimum evoked current of K (MECK) and evaluated its accuracy in predicting sympathetic response to nociceptive stimuli under constant opioid administration. Thirty patients undergoing open surgery under general anesthesia were included. After anesthetic induction, remifentanil was administered at a constant concentration of 2 ng/ml at the effect site followed by tetanus stimulation. MECK was defined as the minimal current needed to produce a change in K. MECK significantly (P < 0.001) correlated with the rate of change of systolic blood pressure during skin incision (ROCBP). Bland-Altman plot analysis using the predicted ROCBP calculated from MECK and the measured ROCBP showed that the prediction equation for ROCBP was highly accurate. This study showed the potential of MECK to predict blood pressure change during surgical incision under opioid analgesia.
Suppression of Autophagy Promotes Fibroblast Activation in P53-deficient Colorectal Cancer Cells
Authors: Inoue Takanori , Hayashi Yoshito , Tsujii Yoshiki , Yoshii Shunsuke , Sakatani Akihiko , Kimura Keiichi , Uema Ryotaro , Kato Minoru , Saiki Hirotsugu , Shinzaki Shinichiro , Iijima Hideki , Takehara Tetsuo
Published: January 2021

Deficiency of p53 in cancer cells activates the transformation of normal tissue fibroblasts into carcinoma-associated fibroblasts; this promotes tumor progression through a variety of mechanisms in the tumor microenvironment. The role of autophagy in carcinoma-associated fibroblasts in tumor progression has not been elucidated. We aimed to clarify the significance of autophagy in fibroblasts, focusing on the TP53 status in co-cultured human colorectal cancer cell lines (TP53-wild-type colon cancer, HCT116; TP53-mutant colon cancer, HT29; fibroblast, CCD-18Co) in vitro. Autophagy in fibroblasts was significantly suppressed in association with ACTA2, CXCL12, TGFβ1, VEGFA, FGF2, and PDGFA mRNA levels, when co-cultured with p53-deficient HCT116sh p53 cells. Exosomes isolated from the culture media of HCT116sh p53 cells significantly suppressed autophagy in fibroblasts via inhibition of ATG2B. Exosomes derived from TP53-mutant HT29 cells also suppressed autophagy in fibroblasts. miR-4534, extracted from the exosomes of HCT116sh p53 cells, suppressed ATG2B in fibroblasts. In conclusion, a loss of p53 function in colon cancer cells promotes the activation of surrounding fibroblasts through the suppression of autophagy. Exosomal miRNAs derived from cancer cells may play a pivotal role in the suppression of autophagy.