bluuebunny/crossref_metadata_2025 huggingface dataset:
Energy-Efficient Clustering and Routing Algorithm Using Hybrid Fuzzy with Grey Wolf Optimization in Wireless Sensor Networks
Authors: Singh Jainendra , Deepika J. , Zaheeruddin  , Sathyendra Bhat J. , Kumararaja V. , Vikram R. , Jegathesh Amalraj J. , Saravanan V. , Sakthivel S.
Published: May 2022

Wireless networking is popular due to the “3 any” concept: anyone, anytime, anywhere. Wireless communication technology advancements have covered the opportunities for sustainable development of low-power, low-cost, multipurpose sensor nodes in wireless sensor networks. In sensor networks, the network layer handles routing problems. Since radio transmission requires a significant amount of energy, it is essential to investigate power efficiency and optimization. As a result, the conservation of energy is a critical concern in wireless sensor networks. Recent research is focused on developing routing algorithms that use less amount of energy during communication, thereby prolonging the network’s life. Wireless sensor networks with energy recovery nodes use nodes that can extract energy from their environment. The fuzzy-GWO method and the energy-saving routing algorithm are proposed and analyzed in this research work. For simulation, the MATLAB 2021b working environment is used. The LEACH, HEED, MBC, FRLDG protocols, along with the proposed protocol F-GWO, are compared. From the obtained results, it is found that the network lifetime is increased by 20%, 14.8%, 12.5%, and 3.8%, respectively. In addition, the proposed method has a 37.5%, 33.3%, 16.6%, and 6.25% reduction in average energy consumption when compared with the conventional algorithms. According to the experimental data obtained through simulation, the proposed F-GWO algorithm outperforms the LEACH, HEED, MBC, and FRLDG in network lifetime, packet delivery ratio, throughput, bit error rate (BER), buffer occupancy, time analysis, and end-to-end delay.
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients
Authors: Crisafulli Giovanni , Sartore-Bianchi Andrea , Lazzari Luca , Pietrantonio Filippo , Amatu Alessio , Macagno Marco , Barault Ludovic , Cassingena Andrea , Bartolini Alice , Luraghi Paolo , Mauri Gianluca , Battuello Paolo , Personeni Nicola , Zampino Maria Giulia , Pessei Valeria , Vitiello Pietro Paolo , Tosi Federica , Idotta Laura , Morano Federica , Valtorta Emanuele , Bonoldi Emanuela , Germano Giovanni , Di Nicolantonio Federica , Marsoni Silvia , Siena Salvatore , Bardelli Alberto
Published: May 2022

The majority of metastatic colorectal cancers (mCRC) are mismatch repair (MMR) proficient and unresponsive to immunotherapy, whereas MMR-deficient (MMRd) tumors often respond to immune-checkpoint blockade. We previously reported that the treatment of colorectal cancer preclinical models with temozolomide (TMZ) leads to MMR deficiency, increased tumor mutational burden (TMB), and sensitization to immunotherapy. To clinically translate these findings, we designed the ARETHUSA clinical trial whereby O6-methylguanine-DNA-methyltransferase (MGMT)–deficient, MMR-proficient, RAS-mutant mCRC patients received priming therapy with TMZ. Analysis of tissue biopsies and circulating tumor DNA (ctDNA) revealed the emergence of a distinct mutational signature and increased TMB after TMZ treatment. Multiple alterations in the nucleotide context favored by the TMZ signature emerged in MMR genes, and the p.T1219I MSH6 variant was detected in ctDNA and tissue of 94% (16/17) of the cases. A subset of patients whose tumors displayed the MSH6 mutation, the TMZ mutational signature, and increased TMB achieved disease stabilization upon pembrolizumab treatment.

Significance:

MMR-proficient mCRCs are unresponsive to immunotherapy. We provide the proof of concept that inactivation of MMR genes can be achieved pharmacologically with TMZ and molecularly monitored in the tissue and blood of patients with mCRC. This strategy deserves additional evaluation in mCRC patients whose tumors are no longer responsive to standard-of-care treatments.

See related commentary by Willis and Overman, p. 1612.

This article is highlighted in the In This Issue feature, p. 1599
Distinct Patterns of Clonal Evolution Drive Myelodysplastic Syndrome Progression to Secondary Acute Myeloid Leukemia
Authors: Guess Tiffany , Potts Chad R. , Bhat Pawan , Cartailler Justin A. , Brooks Austin , Holt Clinton , Yenamandra Ashwini , Wheeler Ferrin C. , Savona Michael R. , Cartailler Jean-Philippe , Ferrell P. Brent
Published: May 2022

Clonal evolution in myelodysplastic syndrome (MDS) can result in clinical progression and secondary acute myeloid leukemia (sAML). To dissect changes in clonal architecture associated with this progression, we performed single-cell genotyping of paired MDS and sAML samples from 18 patients. Analysis of single-cell genotypes revealed patient-specific clonal evolution and enabled the assessment of single-cell mutational cooccurrence. We discovered that changes in clonal architecture proceed via distinct patterns, classified as static or dynamic, with dynamic clonal architectures having a more proliferative phenotype by blast count fold change. Proteogenomic analysis of a subset of patients confirmed that pathogenic mutations were primarily confined to primitive and mature myeloid cells, though we also identify rare but present mutations in lymphocyte subsets. Single-cell transcriptomic analysis of paired sample sets further identified gene sets and signaling pathways involved in two cases of progression. Together, these data define serial changes in the MDS clonal landscape with clinical and therapeutic implications.

Significance:

Precise clonal trajectories in MDS progression are made possible by single-cell genomic sequencing. Here we use this technology to uncover the patterns of clonal architecture and clonal evolution that drive the transformation to secondary AML. We further define the phenotypic and transcriptional changes of disease progression at the single-cell level.

See related article by Menssen et al., p. 330 (31).

See related commentary by Romine and van Galen, p. 270.

This article is highlighted in the In This Issue feature, p. 265
Hemoperfusion with Seraph 100 Microbind Affinity Blood Filter Unlikely to Require Increased Antibiotic Dosing: A Simulations Study Using a Pharmacokinetic/Pharmacodynamic Approach
Authors: Selig Daniel J. , Reed Tyler , Chung Kevin K. , Kress Adrian T. , Stewart Ian J. , DeLuca Jesse P.
Published: May 2022

Introduction: The Seraph® 100 Microbind® Affinity Blood Filter (Seraph 100) is a hemoperfusion device that can remove pathogens from central circulation. However, the effect of Seraph 100 on achieving pharmacodynamic (PD) targets is not well described. We sought to determine the impact of Seraph 100 on ability to achieve PD targets for commonly used antibiotics. Methods: Estimates of Seraph 100 antibiotic clearance were obtained via literature. For vancomycin and gentamicin, published pharmacokinetic models were used to explore the effect of Seraph 100 on ability to achieve probability of target attainment (PTA). For meropenem and imipenem, the reported effect of continuous kidney replacement therapy (CKRT) on achieving PTA was used to extrapolate decisions for Seraph 100. Results: Seraph 100 antibiotic clearance is likely less than 0.5 L/h for most antibiotics. Theoretical Seraph 100 clearance up to 0.5 L/h and 2 L/h had a negligible effect on vancomycin PTA in virtual patients with creatinine clearance (CrCl) = 14 mL/min and CrCl >14 mL/min, respectively. Theoretical Seraph 100 clearance up to 0.5 L/h and 2 L/h had a negligible effect on gentamicin PTA in virtual patients with CrCl = 120 mL/min and CrCl <60 mL/min, respectively. CKRT intensity resulting in antibiotic clearance up to 2 L/h generally does not require dose increases for meropenem or imipenem. As Seraph 100 is prescribed intermittently and likely contributes far less to antibiotic clearance, dose increases would also not be required. Conclusion: Seraph 100 clearance of vancomycin, gentamicin, meropenem, and imipenem is likely clinically insignificant. There is insufficient evidence to recommend increased doses. For aminoglycosides, we recommend extended interval dosing and initiating Seraph 100 at least 30 min to 1 h after completion of infusion to avoid the possibility of interference with maximum concentrations.
O Sistema de Saúde japonês e seus mecanismos de enfrentamento à COVID-19
Authors: Bezerra Lucas Soares , Silveira Maria Mariana Barros Melo da , Cabral Joao Victor Batista , Pitta Maira Galdino da Rocha , Andrade Cesar Augusto Souza de
Published: May 2022

Introdução: apesar de ser o país de maior média de idade no mundo, o Japão tem se destacado no combate à pandemia da COVID-19 (do inglês Coronavirus Disease 2019) ao apresentar reduzidas taxas de contaminação pelo vírus e de mortalidade.
Objetivo: discutir acerca das estratégias em saúde adotadas pelo Japão diante da pandemia da doença da COVID-19, bem como avaliar os dados sobre contaminação e mortalidade japoneses em comparação com os outros quatro países com maior média de idade do mundo (Itália, Alemanha, Portugal e Espanha) e o Brasil.
Metodologia: para avaliação das estratégias em saúde japonesas foi realizada busca nas bases de dados: PubMed, Cochrane e Scielo, utilizando-se combinação dos termos “Japão”, “covid”, “coronavirus” e “sistemas de saúde”, nos idiomas Inglês, Espanhol e Português. Os dados de infecção da COVID-19 foram extraídos do site Our World in Data, correspondendo ao período de 25 de janeiro de 2020 a 30 de julho de 2020.
Resultados: dentre as medidas adotadas pelo país no enfrentamento à pandemia, destacam-se o diagnóstico e resposta precoces à infecção, o rastreamento de contatos, o diagnóstico precoce e disponibilidade de cuidados intensivos para pacientes graves e estímulo a medidas comportamentais de distanciamento. Dentre os países analisados, o Japão apresenta as menores taxas de contaminação e mortalidade em termos absolutos pela COVID-19.
Conclusões: medidas de distanciamento social, diagnóstico e tratamento precoces parecem ter contribuído para o sucesso no combate à COVID-19 no Japão. No período estudado, em milhão de habitantes, o Japão teve 6,13 casos de Covid, enquanto o Brasil apresentou 218,26 casos. Já no número de mortes confirmadas pela doença, o primeiro teve uma taxa de 0,23 enquanto o segundo de 5,16 casos por milhão de habitantes. É possível, a partir do conhecimento dessas medidas, buscar mecanismos semelhantes ao traçar políticas de saúde no enfrentamento de pandemias em outros países.
Vitamin D Enhances Hematoma Clearance and Neurologic Recovery in Intracerebral Hemorrhage
Authors: Liu Jiaxin , Li Ning , Zhu Zhiyuan , Kiang Karrie Mei-Yee , Ng Anson Cho Kiu , Dong Celia M. , Leung Gilberto Ka-Kit
Published: May 2022

Background:

Erythrophagocytosis by reparative monocyte-derived macrophage contributes to hematoma clearance and neurological recovery after intracerebral hemorrhage (ICH). Vitamin D (VitD) is a neuroprotective hormone and regulates the differentiation of monocyte-derived macrophage from monocytes. In this study, we examined the effects of VitD supplementation on monocyte-derived macrophage and hematoma clearance in rodent with ICH.

Methods:

Neurobehavioral functions and hematoma volume were assessed using a collagenase injection model in both young- and middle-aged mice with or without VitD treatment given 2 hours post-ICH induction. We used flow cytometry to analyze CD36 expression and macrophage and undifferentiated monocyte cell numbers during in vivo erythrophagocytosis in collagenase and autologous blood injection models. Western blot analysis and immunofluorescence were used to assess the expression levels of the PPAR-γ (peroxisome proliferator-activated receptor γ)-CD36 axis and CD206. A macrophage differentiation study was conducted on murine bone marrow-derived monocytes.

Results:

VitD promoted neurological recovery and facilitated hematoma clearance in both young- and middle-aged mice after ICH. Within the perihematomal region, mature macrophages, rather than undifferentiated monocytes, expressed higher levels of CD36 in driving erythrocyte clearance. VitD increased the macrophage number but decreased the monocyte number and elevated the levels of CD36 and PPAR-γ in the brain. In vitro, VitD accelerated the differentiation of reparative macrophages from bone marrow-derived monocytes.

Conclusions:

VitD promotes reparative macrophage differentiation, facilitates hematoma clearance, and improves neurobehavioral performance in mice with ICH, suggesting that VitD should be further examined as a potentially promising treatment for ICH.
Cultivating Sustainability Thinkers: Analyzing the Routes to Psychological Ownership in Local Business Units of Multinational Enterprises (MNEs)
Authors: Kurki Martina , Lähdesmäki Merja
Published: May 2022

Although present research shows that ambitious corporate sustainability objectives improve employee engagement in business organizations, there is scarcity of research showing how employees engage in corporate sustainability objectives and become autonomous sustainability thinkers. We suggest that a strong, individual level of psychological ownership of corporate sustainability is a precondition for the development of sustainability thinking, and examine the factors that influence the emergence of such feelings of ownership. Our qualitative study, based on 29 interviews conducted in seven Finnish local business units from three different technology-oriented multinational enterprises (MNEs), shows that several key factors can have contradictory effects, both strengthening and hindering the routes to psychological ownership of corporate sustainability. While these contradictory effects may potentially lead to confusion among employees, our findings may help managers to avoid pitfalls in developing a more sustainability-oriented organizational culture. Moreover, by applying the theory of psychological ownership, our study contributes to the business sustainability research by providing new theoretical opportunities to understand the process of how individuals may become engaged in enhancing business sustainability.
Les femmes et les mythes hindous dans le théâtre hindi
Authors: Dimitrova Diana
Published: May 2022

This article examines the portrayal of women in Hindi drama. In the following, we will examine the cultural segments that have influenced the development of the dramatic genre of Hindi. We will analyze Hindu images of the feminine according to three mythical figures. We propose to understand the interpretation of the feminine through these three mythical figures of great importance in the Hindu tradition. In support of our theoretical discussion, we have chosen to focus on the dramas of three representative playwrights, Bharatendu Harishcandra, Jayshankar Prasad and Jagdishcandra Mathur. We will deal with the ways Hindu images of the feminine have been reinterpreted in Hindi theater of pre-independence India. By means of a thematic analysis and ideological criticism, we aim to understand how Hindu myths have been used in order to affirm or contest Hindu female models of the submissive woman or the independent woman.
Investigation of the compaction behaviour of a quasi-unidirectional non-crimp fabric during the vacuum infusion process
Authors: Droste David , Krishnappa Likith , Bornemann Sarah , Ohlendorf Jan-Hendrik , Vargas Gleason Minerva G , Herrmann Axel S , Lang Walter
Published: May 2022

The compaction behaviour of technical textiles such as non-crimp fabrics (NCF) is of much interest to build high quality parts in liquid composite moulding processes (LCM). In this paper, the compaction response of a glass fibre NCF was investigated in two different ways: (1) characterisation tests via a universal testing machine and (2) height measurements via a line laser measurement unit during the infusion process. Results from both measurement systems are compared and it is found that the results of characterisation tests via testing machine can be used only to a certain extent. The pressure-thickness correlation during the infusion process cannot be described by the results of the testing machine, while the compaction results before and after the infusion process are in good agreement for both the methods. With the data of the line laser measurement, a model for the pressure-thickness correlation is derived, which can be used in future simulations. The infusion process was carried out using different scenarios at the vent, on the one hand a semi-permeable membrane and on the other hand an omega profile at the venting port. The results obtained using these two different venting scenarios were compared and it was found that using a semi-permeable membrane as an outlet can lead to thicker parts (up to 10 %).
The Profitability of Purchase Limits During Shortages
Authors: Moon Jihwan , Shugan Steven M.
Published: May 2022

Pandemics, natural disasters (e.g., hurricanes, droughts, fires), strikes, piracy, and other events can unexpectedly disrupt supply or spike demand, creating shortages. Unlike ordinary stockouts caused by store-specific inventory policies, shortages involve the entire supply chain. One tool for managing shortages is imposing purchase limits. Purchase limits restrict the quantity each shopper can purchase of the scarce product (e.g., gasoline, toilet paper, sanitizers, meat, batteries), possibly increasing availability to other shoppers. Although altruistic stores might use purchase limits for egalitarian goals (e.g., reducing hoarding, waste, panic buying, arbitrage, unfair distribution), the authors find that profit-maximizing stores can use purchase limits to increase profits during shortages. These findings suggest that stores’ price-and-limit strategies depend on shortage severity, store size, competition, and seasonality. For moderate shortages, large multiproduct stores, where average shopping basket sizes are large, should maintain low prices and impose limits, whereas small stores should increase prices and not impose limits. For severe shortages, by contrast, large stores should keep low prices but not impose limits, whereas small stores should increase prices and impose limits. Generally, large stores benefit from increased future store traffic when they impose limits. Interestingly, purchase limits can improve both store profits and, with lower prices, consumer surplus.
Perceptions of White-Collar Crime Seriousness: Unpacking and Translating Attitudes into Policy Preferences
Authors: Simpson Sally S. , Galvin Miranda A. , Loughran Thomas A. , Cohen Mark A.
Published: May 2022

Objectives

Test the role of individual and crime characteristics on public opinions of white-collar crime seriousness and support for crime reduction policy; consider the relationship between perceptions of crime seriousness and support for public policies to reduce white-collar crime.

Methods

Data from a nationally-representative survey. Respondents ( n = 2,050) rated ten white-collar crimes, relative to a street crime (burglary) and also indicated their relative support (i.e., willingness to pay) for 16 policies to reduce various types of white-collar crime. Models incorporate respondent-level random effects to account for multiple ratings per respondent.

Results

Crimes committed by organizations are perceived more seriously than those committed by individuals. Perceptions of a white-collar crime as more serious than burglary increase the likelihood of supporting prevention programs. Race and political party are related to both perceptions of crime seriousness and support for prevention policy.

Conclusions

There may be less consensus around perceptions of white-collar crime seriousness than for other crime types. Perceptions of crime seriousness are a function of both individual and crime characteristics that structure assessments of risk, harmfulness, and wrongfulness. Group differences may be related to differences in awareness of the scope, harms, and perceived victimization risk associated with particular crime types.
Associations Between Smartphone Use for Physical Activity by South Korean College Students and Behavioral Change Constructs of the Transtheoretical Model
Authors: Kim Byoung-hoon , Lee Hyo
Published: May 2022

We examined associations between smartphone uses to assist physical activity (PA) and change constructs of the transtheoretical model (TTM) among Korean college students. Our participants were 242 college students who completed a cross-sectional survey of their smartphone use, PA, and TTM constructs. We applied Poisson regression models to test the associations between stages of change and smartphone PA use frequencies in four categories over the previous week: 1= watching PA instruction videos; 2 = tracking PA; 3 = searching and booking sites for PA; and 4 = finding and making appointments with PA partners. The associations between these smartphone uses and participants’ self-efficacy, decisional balance, processes of change, and PA were tested via ordinary least squares regression models. Results were that participants in the precontemplation and maintenance stages were the least and most frequent users of the smartphones in all four categories, respectively. Category one usage was positively associated with participants’ scores on pros (β = .22, p = .004), cognitive processes of change (β = .30, p < .001), and behavioral processes of change (β = .28, p < .001). Category two usage was positively associated with PA (β = .06, p = .048). While category three usage was not significantly associated with any TTM constructs except for stages of change, category four usage was positively associated with self-efficacy (β = .28, p < .001), pros (β = .30, p < .001), cognitive processes of change (β = .31, p < .001), behavioral processes of change (β = .06, p <. 001), and PA (β = .45, p < .001). These findings suggest that (a) active college students are likely to take advantage of smartphone to assist their PA, and (b) smartphones can help motivate college students toward regular PA.
Delivery of Distance Counselling to Survivors of Sexual Violence: A Scoping Review of Promising and Best Practices
Authors: Leroux Janette , Johnston Natalie , Brown Ashley-Anne , Mihic Alanna , DuBois Denise , Trudell AnnaLise
Published: May 2022

Distance counselling holds immense potential for improving access to trauma supports for survivors of sexual violence (SV), and particularly for under-served groups who disproportionately experience violence and myriad barriers to accessing in-person supports. And yet, the evidence-base for the practice and delivery of distance counselling remains under-developed. In the context of COVID-19, where telehealth applications have undergone a rapid uptake, we undertook a scoping review of existing evidence of therapeutic and organizational practices related to the real-time (synchronous) delivery of distance counselling to survivors of SV. We based our scoping review methods on Arksey and O’Malley framework and in accordance with the guidance on scoping reviews from the Joanna Briggs Institute (JBI) and PRISMA reporting guidelines for scoping reviews. A comprehensive search of MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, and Sociological Abstracts was undertaken in October 2020, and again in March 2022. Searching, reviewing, appraisal, and data extraction was undertaken by two reviewers. In total, 1094 records were identified that resulted in 20 studies included. Descriptions, findings, and recommendations were gleaned and synthesized into potential practices using inductive thematic analysis. While many studies have an appreciative orientation to distance counselling, these benefits tend to be framed as non-universal, and conditional on survivor safety, flexibility, anonymity, survivor choice, strong and inclusive technology, and a supported workforce.

Despite the limited evidence-base, we present several clusters of findings that, taken together, can be used to support current COVID-19 distance counselling initiatives with survivors, as well as guide the future development of best practices.
The Social Validity of Using the Matrix Approach in Early Intervention With Children Who Are Blind or Have Low Vision
Authors: Ely Mindy S. , Ostrosky Michaelene M. , Barton Allison
Published: May 2022

Introduction: This paper provides a report of social validity and its usefulness in understanding study effects. Social validity data were drawn from a larger single-case study designed to investigate the effectiveness of the Matrix Approach in the practice of early intervention visual impairment professionals. Methods: Qualitative measures were used to assess social validity. According to Wolf (1978), validation of a study should encompass the significance of goals, appropriateness of procedures, and importance of outcomes. Therefore, data sources were created to provide evidence of social validity in these areas including pre- and post-intervention interviews of parents and professionals. Results: Three themes emerged from the social validity data. These are organized under the topics introduced by Wolf (1978) and identified as measures of quality by Horner et al. (2005). The themes are (a) Goals: role of the parent as learner and the professional as expert before using the Matrix Approach, (b) Procedures: helpfulness of coaching and the structure of the Matrix Approach, and (c) Outcomes: personal and professional growth as a result of using the Matrix Approach. Discussion: Evaluation of social validity in single-case research is an important component in a study’s design and in interpreting the study’s outcomes. Wolf’s framework proved valuable in promoting a robust evaluation of study effectiveness, especially when incorporated into the study design. Intentionally planning to measure social validity held the researchers accountable to the practical needs of the participants. In fact, there is value in gathering social validity data at various points in a study. Further, hearing the perspective of stakeholders can provide valuable insights as researchers seek to understand the complexities of change evident in the outcomes of a study. Implications for Practitioners: Collaborative planning is an essential component of early intervention. The Matrix Approach shows promise as a mechanism to foster such collaboration.
Prefatory Essay: Unfinished Conversations With Jean Anyon
Authors: Tuck Eve , Habtom Sefanit
Published: May 2022

In this essay, Eve Tuck and Sefanit Habtom consider three contemporary conversations in the field of urban education: Urban education takes place on Indigenous land; diversity is not it, and social movements do more than we can know at a given time. Tuck imagines these may have been conversations that her mentor, Jean Anyon, would be writing, mentoring, or thinking about. Drawing from Anyon and Tuck’s conversations from nearly 20 years ago, the coauthors of this essay are connected within another mentoring relationship. This time, Tuck is the professor and Habtom is a doctoral student. Tuck and Habtom continue the tradition of unfinished conversations that might extend beyond the time frames of a lived life, of a mentoring relationship, and historical moment.
Deficit-Oriented Beliefs, Anti-Black Policies, Punitive Practices, and Labeling: Exploring the Mechanisms of Disproportionality and Its Impact on Black Boys in One Urban “No-Excuses” Charter School
Authors: Marsh L. Trenton S. , Walker Larry J.
Published: May 2022

Background/Context:

Embedded in “common sense” and state-mandated reforms to close “the achievement gap,” the urban school, especially those sites with a no-excuses orientation to learning, can produce and reproduce the carceral state in students’ lives. The seemingly innocuous policies and processes limit access to educational opportunities and create disproportionate out-of-class time, which can emerge as the connective tissue for criminalization and the school-to-prison nexus that disproportionately affects Black males in the United States.

Purpose/Objective/Research Question/Focus of Study:

The objective of the study was to illuminate the more unspoken mechanisms of disproportionality in school while concurrently raising awareness of how everyday practices, like school-imposed mis/labeling, contribute to the symbolic violence and dehumanization of Black and Latinx boys in school.

Research Design:

The article includes purposeful observations and semi-structured interview data with school personnel and students drawn from a 14-month ethnographic study.

Findings/Results:

The findings from this study revealed that the mechanisms of disproportionality ranged from explicit anti-Black policies to more tacit systems and processes, but all reflected how the no-excuses environment contributes to the connective tissue of criminalization and the school-to-prison nexus for boys of Color. The finding centers on three systems and policies that are influenced by carceral logic and the enforcement of student alienation.

Conclusion/Recommendations:

The findings from the study reveal the need for a radical transformation of no-excuses public charter schools, one that is community-based and rooted in an Afrocentric education. If educators and other school personnel are working in tandem with community members, they can reassess their negative misperceptions of minoritized communities that begin to shape infractions rooted in anti-Blackness. A community-based approach can begin to dismantle the school-to-prison nexus. Furthermore, an Afrocentric education approach requires school personnel to understand the history and culture of people of African descent and to see students’ full humanity. Here, students’ lived experiences would be centered within the diaspora, while sociocultural norms that may have been criminalized in the past would be valued and accepted.
Systematic Review of Video-Based Instruction to Teach Employment Skills to Secondary Students with Intellectual and Developmental Disabilities
Authors: Sun Xiaoning , Brock Matthew E.
Published: May 2022

Individuals with intellectual and developmental disabilities (IDD) have a significantly lower employment rate than those without disabilities. One promising intervention for improving employment outcomes is video-based instruction. The purpose of this systematic review was to examine the application of video-based instruction (VBI) to teach employment skills to secondary students with IDD. Twenty-one studies included in this review provide strong evidence that VBI is an effective intervention to prepare secondary students with IDD for future employment, among which video prompting with error correction was the most frequently used intervention combination. However, the application of VBI was limited to a small number of occupations and contexts. Specifically, most studies were conducted in school settings and focused on technical skills related to performing repetitive tasks. We recommend that future research focus on the broader application of VBI to more diverse employment skills, with an emphasis on generalization to authentic employment settings.
Investigation of university websites from technology acceptance model and information architecture perspective: A case study
Authors: Sönmez Ferdi , Aydin Uygar , Perdahci Ziya N
Published: May 2022

Factors, such as whether a website is designed to be user-oriented beyond its mere visual design, its effectiveness and efficiency, its usability, and the organisation of the information it offers, have come to the fore once again after the Covid-19 pandemic. It has been evident that the link structure in a website, better known as the website’s information architecture, helps the practitioners with identifying factors that affect the usability of a website. In this sense, practitioners must ensure that the information architecture supports the usage intentions of a websites’ visitors to better serve and motivate them. However, in many cases, different types of users navigate websites that contain immense amounts of information, so understanding their needs is also important for practitioners. In parallel, this article addresses the problem that different visitors of a large-scale website will need to navigate through dense information to find the information they are looking for, and the information architecture of the website must support different user tasks for the website to be widely adopted. Thus, unlike previous studies, this article combines the principles of information architecture and the technology acceptance model to investigate the effect of information architecture on visitor’s usage intentions. The work also guides practitioners in developing architectural strategies to better enable visitors to fulfil their objectives in the least amount of time.
Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform
Authors: Ramot Yuval , Kronfeld Noam , Ophir Yakir , Ezov Nati , Friedman Sheli , Saloheimo Markku , Vitikainen Marika , Ben-Artzi Hanna , Avigdor Avi , Tchelet Ronen , Valbuena Crespo Noelia , Emalfarb Mark , Nyska Abraham
Published: May 2022

Coronavirus disease 2019 (COVID-19) has caused the ongoing COVID-19 pandemic and there is a growing demand for safe and effective vaccines. The thermophilic Thermothelomyces heterothallica filamentous fungal host, C1-cell, can be utilized as an expression platform for the rapid production of large quantities of antigens for developing vaccines. The aim of this study was to evaluate the local tolerance and the systemic toxicity of a C1-cell expressed receptor-binding domain (C1-RBD) vaccine, following repeated weekly intramuscular injections (total of 4 administrations), in New Zealand White rabbits. The animals were sacrificed either 3 days or 3 weeks following the last dose. No signs of toxicity were observed, including no injection site reactions. ELISA studies revealed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulin G antibodies in the sera of C1-RBD-treated animals starting from day 13 post injection, that were further elevated. Histopathology evaluation and immunohistochemical staining revealed follicular hyperplasia, consisting of B-cell type, in the spleen and inguinal lymph nodes of the treated animals that were sustained throughout the recovery phase. No local or systemic toxicity was observed. In conclusion, the SARS-CoV-2 C1-RBD vaccine candidate demonstrated an excellent safety profile and a lasting immunogenic response against receptor-binding domain, thus supporting its further development for use in humans.
Nutraceuticals and dietary supplements: Disparities in usage and potential for harm
Authors: Kaptur Bradley , Peterman Nicholas , Lee Jan
Published: May 2022

Background: The use of nutraceuticals and dietary supplements has a complex history. Aim: This work seeks to discuss the current state of nutraceuticals and dietary supplements, with a particular focus on the ambiguity of these terms, their current usage, potential harms, roles within the healthcare system, and associated disparities. Methods: This work reviews recent literature spanning the history of nutraceuticals and expands upon recommendations made by previous authors. Results: While a substantial portion of the United States population consumes these substances, their safety profiles are rarely well characterized. Taking a broad definition of these terms paints a picture of harmless use by a population that is middle-aged, educated, and white. However, focusing on specific substances reveals concerning disparities in race, ethnicity, income, physical health, and health literacy. This is of particular concern when looking at the side effects of these supplements both in isolation and due to drug-supplement interactions. Conclusions: In this work, the authors build upon the recommendations of others to propose ways in which physicians and healthcare systems can work to reduce the disproportionate harms of these substances on historically marginalized groups.
Technique for circuit exchange in high-risk patients on extracorporeal life support
Authors: A Siddiqui Najam , Dominguez Anibal , Sharma Arunima , Conrad Steven A
Published: May 2022

Exchanging circuits in patients undergoing extracorporeal life support (ECLS) for component failure can be a life-threatening endeavor if the patient has no native organ function and is fully dependent on ECLS. Traditional circuit exchanges involve replacing the entire circuit at once, leading to a sufficient loss of support that risks hemodynamic deterioration in the absence of mechanical ventilation or mechanical circulatory support. A staged approach is described using a parallel circuit configuration to reduce the risk of physiologic decompensation in patients with total dependence on ECLS. The approach involves splicing in a second primed circuit in parallel, transitioning flow incrementally from old to new circuit, and removing the old circuit. This approach provides hemodynamic and physiologic stability even in patients with absent underlying cardiopulmonary function.
Safety and effectiveness of simultaneous localization of multiple lung nodules using coils and risk factors for pneumothorax: a retrospective study
Authors: Ai Min
Published: May 2022

Background

Localization of lung nodule before video-assisted thoracoscopic surgery (VATS) can help the surgeon to quickly and accurately find the lesion during surgery.

Purpose

To evaluate the safety and effectiveness of using coils to simultaneously locate multiple lung nodules under computed tomography guidance and to clarify the risk factors for pneumothorax.

Material and Methods

From January 2020 to December 2020, 61 patients underwent simultaneous localization of multiple lung nodules (Group A) and 120 patients underwent localization of a single lung nodule (Group B). The demographics, information related to localization procedure, and incidence of pulmonary hemorrhage and pneumothorax were compared between the patients in Groups A and B. Group A was further divided into a pneumothorax group and non-pneumothorax group. Univariate and multivariate regression analyses were used to determine the risk factors for pneumothorax in patients who underwent simultaneous localization of multiple lung nodules using coils.

Results

The success rates in Groups A and B were 96.9% and 96.7%, respectively (P = 1.000). The number of pleural punctures ( P<0.001), the positioning operation time ( P<0.001), the rates of pneumothorax ( P<0.001), and hemorrhage ( P = 0.034) were higher in Group A than in Group B. The pneumothorax and bleeding in Group A did not require special treatment. Transfissural puncture (odds ratio [OR]=16.798; P = 0.033) and the numbers of pleural punctures (OR=2.437; P = 0.013) were independent risk factors for pneumothorax caused by simultaneous localization of multiple lung nodules, and hemorrhage was a protective factor against pneumothorax (OR=0.069; P = 0.002).

Conclusion

Simultaneous localization of multiple lung nodules using coils under computed tomography guidance is safe and effective. Transfissural puncture and higher numbers of pleural punctures will increase the risk of pneumothorax, whereas hemorrhage will reduce the risk of pneumothorax.
Timing of headache after COVID-19 vaccines and its association with cerebrovascular events: An analysis of 41,700 VAERS reports
Authors: Garcia-Azorin David , Baykan Betül , Beghi Ettore , Doheim Mohamed F , Fernandez-de-las-Penas Cesar , Gezegen Hasim , Guekht Alla , Hoo Fan Kee , Santacatterina Michele , Sejvar James , Tamborska Arina A , Thakur Kiran T , Westenberg Erica , Winkler Andrea S , Frontera Jennifer A ,   Contributors from the Global COVID-19 Neuro Research Coalition
Published: May 2022

Background

Delayed-onset of headache seems a specific feature of cerebrovascular events after COVID-19 vaccines.

Methods

All consecutive events reported to the United States Vaccine Adverse Reporting System following COVID-19 vaccines (1 January to 24 June 2021), were assessed. The timing of headache onset post-vaccination in subjects with and without concomitant cerebrovascular events, including cerebral venous thrombosis, ischemic stroke, and intracranial haemorrhage was analysed. The diagnostic accuracy in predicting concurrent cerebrovascular events of the guideline- proposed threshold of three-days from vaccination to headache onset was evaluated.

Results

There were 314,610 events following 306,907,697 COVID-19 vaccine doses, including 41,700 headaches, and 178/41,700 (0.4%) cerebrovascular events. The median time between the vaccination and the headache onset was shorter in isolated headache (1 day vs. 4 (in cerebral venous thrombosis), 3 (in ischemic stroke), or 10 (in intracranial hemorrhage) days, all P < 0.001). Delayed onset of headache had an area under the curve of 0.83 (95% CI: 0.75–0.97) for cerebral venous thrombosis, 0.70 (95% CI: 0.63–76) for ischemic stroke and 0.76 (95% CI: 0.67–84) for intracranial hemorrhage, and >99% negative predictive value.

Conclusion

Headache following COVID-19 vaccination occurs within 1 day and is rarely associated with cerebrovascular events. Delayed onset of headache 3 days post-vaccination was an accurate diagnostic biomarker for the occurrence of a concomitant cerebrovascular events.
Sustainable Road Shoulders and Pavement Protection for Expansive Soil Zones
Authors: Dafalla Muawia , Shaker Abdullah , Al-Shamrani Mosleh
Published: May 2022

The design of sustainable infrastructure roads in semi-arid highly expansive soil is of concern to the geotechnical and pavement design engineers. The damage and distress caused to highways and roads in areas with high swell potential occur as a result of ingress and infiltration of water to the underside of light pavements. These pavements exert very low stresses on the ground. Protection of subgrade and shoulders against variation in moisture content as a result of seasonal weather fluctuation and floods can help in establishing a sustainable pavement for an extended lifetime. Predicting the response of a subgrade soil subjected to different rainfall intensity and frequencies is very challenging. The approach proposed in this study is to target a reduction of moisture exposure to prevent water from entering the systems. However, efficient protection is required when severe floods occur so as to remove water from the shoulders in a short time. The sloping shoulders are intended to guide floodwater away from the pavement. Clay-sand liners can be constructed as a dressing layer along the shoulders or within the body of the shoulder extending up to the toe of the slope or beyond. Assessment of a typical sand–clay liner was conducted. Suggested designs were based on characterization, compressibility, and hydraulic conductivity tests. It was found that stresses exerted on the liners do not pose a significant settlement hazard.
Blue-Light Therapy for Seasonal and Non-Seasonal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Do André , Li Victor W. , Huang Samantha , Michalak Erin E. , Tam Edwin M. , Chakrabarty Trisha , Yatham Lakshmi N. , Lam Raymond W.
Published: May 2022

Objectives

To determine the efficacy and safety of blue-light therapy in seasonal and non-seasonal major depressive disorder (MDD), by comparison to active and inactive control conditions.

Methods

We searched Web of Science, EMBASE, Medline, PsycInfo, and Clinicaltrials.gov through January 17, 2022, for randomized controlled trials (RCTs) using search terms for blue/blue-enhanced, light therapy, and depression/seasonal affective disorder. Two independent reviewers extracted data. The primary outcome was the difference in endpoint scores on the Structured Interview Guide for the Hamilton Depression Rating Scale - Seasonal Affective Disorder (SIGH-SAD) or the Structured Interview Guide for the Hamilton Depression Rating Scale with Atypical Depression Supplement (SIGH-ADS) between blue light and comparison conditions. Secondary outcomes were response (≥ 50% improvement from baseline to endpoint on a depression scale) and remission rates (endpoint score in the remission range).

Results

Of 582 articles retrieved, we included nine RCTs ( n = 347 participants) assessing blue-light therapy. Seven studies had participants with seasonal MDD and two studies included participants with non-seasonal MDD. Four studies compared blue light to an inactive light condition (efficacy studies), and five studies compared it to an active condition (comparison studies). For the primary outcome, a meta-analysis with random-effects models found no evidence for the efficacy of blue-light conditions compared to inactive conditions (mean difference [MD] = 2.43; 95% confidence interval [CI], −1.28 to 6.14, P = 0.20); however, blue-light also showed no differences compared to active conditions (MD = −0.11; 95% CI, −2.38 to 2.16, P = 0.93). There were no significant differences in response and remission rates between blue-light conditions and inactive or active light conditions. Blue-light therapy was overall well-tolerated.

Conclusions

The efficacy of blue-light therapy in the treatment of seasonal and non-seasonal MDD remains unproven. Future trials should be of longer duration, include larger sample sizes, and attempt to better standardize the parameters of light therapy.
Long term accelerated influence on thermo-mechanical properties of glass/carbon fiber reinforced interpenetrating polymer network hybrid composites
Authors: Priya Karjala Santhosh , Vijaya Kumar K R , Suresh G , Ganesamoorthy R , Vezhavendhan R , Meenakshi C M
Published: May 2022

The prime importance of this work is that to compare the influence of hygrothermal analysis on the physical properties of different variant of interpenetrating polymer network (IPN) blend reinforced with E-Glass/Carbon and combination of both (hybrid) fibers. In this study, combinations of epoxy (EP)/polyurethane (PU), vinyl ester (VER)/polyurethane (PU), and epoxy (EP)/vinyl ester (VER) have been taken as the matrix material (IPN) to reinforce the glass, carbon, and combination of both fibers. Moreover, prepared specimens are subjected with boiling water immersion test by maintaining the temperature of 45°C, 55°C, and 65°C in order to thoroughly understand the influence of moisture absorption and temperature in their physical attribution as per ASTM standards. Besides, to better understand the thermal stability and compatibility, thermal-gravimetric (TGA) analysis and burn-off test were conducted as well. During this study, it was found that, combination of VER/PU possesses the high moisture absorption resistance amongst all variants (0.725% for 45°C, 0.854% for 55°C, 1.234 for 65°C). Similarly, epoxy/vinyl ester reinforced glass fiber IPN laminate (EVG) has shown notable TGA value as 418.6°C, as well burn-off test also shown that hybrid IPN composites have better wettability (less void presence) than all other laminates (EPGC-0.9%, VPGC-0.89%, EVGC-0.92%). Further, losses of physical strengths have been noticed on all specimens upon subjection on hygrothermal environment irrespective of IPN blend and fiber constituents.