bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Klotho G395A Gene Polymorphism in Atherosclerotic Cardiovascular Disease and Mortality Risk Scores in Non-dialysis Chronic Kidney Disease
Authors: Susilo Hendri , Pikir Budi Susetyo , Thaha Mochammad , Alsagaff Mochamad Yusuf , Suryantoro Satriyo Dwi , Wungu Citrawati Dyah Kencono , Budi David Setyo , Andre Laurentius , Pakpahan Cennikon
Published: September 2022

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Klotho expression was reduced in patients with CKD, leading to vascular calcification, endothelial dysfunction, and atherosclerosis. We investigated the role of the klotho G395A gene polymorphism and plasma klotho level in the ten-year risk of atherosclerotic cardiovascular disease (ASCVD) and CVD mortality in CKD patients.METHODS: We used the PCR-CTPP assay method to genotype klotho G395A single nucleotide polymorphism (SNP) in 72 non-dialysis CKD patients. The klotho level was determined using the enzyme-linked immunoassay (ELISA) method. Path analysis was used to determine the relationship between the klotho G395A SNP, plasma klotho level, ASCVD risk score, and CVD mortality risk score.RESULTS: Our results showed that the GA genotype had lower plasma klotho levels than the GG genotype (path coefficient=-0.185, p=0.000). There was a significant negative correlation between plasma klotho level and the ASCVD risk score (r=-0.243, p=0.040), but no significant correlation was found between plasma klotho level and the CVD mortality risk score (r=-0.145, p=0.225). Path analysis showed that plasma klotho level had a significant negative direct effect on ASCVD risk score (path coefficient=-0.272, p=0.000) and an indirect effect on CVD mortality risk score (path coefficient=0.187, p=0.005).CONCLUSION: Klotho G395A SNP might reduce lower plasma klotho levels, which increased ASCVD and CVD mortality risk scores in non-dialysis CKD patients. However, other risk factors such as age, CKD stages, hypertension, and smoking should be taken into consideration. Therefore, large-scale genetic association studies with adjusted variables could be conducted in various ethnic groups for a more robust result.KEYWORDS: klotho, single nucleotide polymorphism, cardiovascular disease, chronic kidney disease
Thymoquinone Modulates Local MMP-9, IL-10, and IgG in Sciatic Nerve Crush Injury Animal Model
Authors: Besin Valentinus , Bajamal Abdul Hafid , Sudiana I Ketut , Agil Mangestuti , Nugraha Jusak , Machfoed Mohammad Hasan , Notopuro Paulus Budiono , Naesilla Naesilla
Published: September 2022

BACKGROUND: Interleukin (IL)-10 is involved in Wallerian degeneration after peripheral nerve crush injury. Oral thymoquinone was previously observed to decrease local immunoglobulin-G (IgG) in a crush-injured rat model. No study has evaluated the pathway of various thymoquinone dosages on local IgG and IL-10 in this injury.METHODS: This experimental study used 126 Rattus norvegicus Wistar rats that were divided into 18 groups: six groups received a placebo, the other six groups received thymoquinone at 100 mg/kg/day and the last six groups received thymoquinone at 250 mg/kg/day, respectively. Rats were sacrificed at 12, 18, 24, 5x24, 6x24, and 7x24 hours. Matrix metalloproteinase-9 (MMP-9), IL-10, and local IgG levels were assessed by Enzyme-Linked Immunosorbent Assay (ELISA). The nuclear factor KappaB (NF-κB) expressions on Schwann cells were examined by flow cytometry. Path analysis was performed using SmartPLS.RESULTS: The path analysis showed that 100mg/kg/day of thymoquinone significantly decreased NF-κB expression. However, NF-κB did not affect local MMP-9, and MMP-9 had no significant relationship with local IL-10 and IgG. Thymoquinone 250 mg/kg/day also significantly inhibited NF-kB expression, decreased local MMP-9, and, in turn, decreased local IL-10 and IgG.CONCLUSION: Administration of oral thymoquinone 250 mg/kg/day decreases local IgG and IL-10 levels via suppressing NF-κB expression and MMP-9 leveKEYWORDS: thymoquinone, crush injury, IgG, IL-10, MMP-9, NF-κB
Gramrnar, Structure, and Essence
Authors: Anscombe G.E.M.
Published: September 2022

No contiene resumen
“La filosofía se ha vuelto más personal”: Agnes Heller en conversación con la Redacción de Areté
Authors: Heller Agnes
Published: September 2022

Agnes Heller conversó con la Redacción de Areté el 24 de abril de 2003, durante una visita a la Universidad Católica para dictar la Lección Inaugural del Año Académico de la Facultad de Letras y Ciencias Humanas. En la conversación estuvieron presentes los profesores Pepi Patrón, Fidel Tubino y Miguel Giusti.
Virtudes cívicas procedimentales, democracia participativa y educación ciudadana
Authors: Pereira Gustavo
Published: September 2022

La modernidad impone condiciones para la reflexión acerca de la democracia participativa. En tal sentido, un irrebasable conjunto de derechos básicos funciona como marco para la participación ciudadana y opera como parámetro para la presentación de las virtudes cívicas. En función de esto último, en este trabajo se expondrá una teoría de la virtud de corte procedimental, presentando cuatro virtudes que aseguran lacondición de ciudadanía en su mayor expresión. Estas virtudes son conceptualmente diferenciadas de los valores cívicos como forma de establecer criterios normativos diferenciales para la implementación de políticas públicas. Por último se presentan tres dimensiones para la educación ciudadana: una de corte estrictamente curricular, una personal vinculada al desarrollo de las capacidades básicas del ciudadano, y una dimensión social que tiene que ver con el rol de las instituciones de la sociedad civil.
Peirce, Wittgenstein y Davidson: coincidencias anti-escépticas
Authors: Kalpokas Daniel
Published: September 2022

Este artículo pone de manifiesto algunos puntos comunes en lasrespuestas al escepticismo de Peirce, Wittgenstein y Davidson. En cada caso, la respuesta al escepticismo cartesiano consiste en señalar el carácter contradictorio de la misma duda escéptica. Más específicamente, los tres filósofos están de acuerdo en los siguientes puntos: (i) a fin de hacer frente al desafío escéptico,debemos examinar sus bases sin conceder los términos en los que se plantea el desafío; (ii) el escéptico no puede dudar sin asumir algunos contenidos proposicionales como verdaderos. En este sentido, el escéptico incurre en contradicción performativa; (iii) en su desafío, el escéptico omite la dimensión práctica del lenguaje y del conocimiento. Ese es el origen de sus dificultades.
Sujeto liberal y patologías sociales
Authors: Pereira Gustavo
Published: September 2022

En este trabajo se presentan las limitaciones de la idealización del sujeto liberal. Sus características distintivas, que lo colocan como un sujeto escasamente vulnerable a las circunstancias a la vez que aseguran la posibilidad de evaluación de los fines y preferencias, limitan la posibilidad de percepción de los fenómenos de colonización del mundo de la vida. Solamente una modificación detal idealización a través de la incorporación de la autorreflexión profunda podrá enfrentar los fenómenos colonizadores. A su vez, esta nueva edición del sujeto será capaz de incidir en la relevancia que tiene el comportamiento personal en el consumismo y la aplicabilidad de los principios de justicia.
El imaginario geométrico del hombre que delibera. Esquemas de ejercicio de la fantasi/a bouleutikh/ en Aristóteles
Authors: Cattanei Elisabetta
Published: September 2022

El estudio parte de la discusión de De anima, III, 11, 434a7-10: a diferencia de las interpretaciones más difundidas del pasaje, que dependen considerablemente del comentario de Filopón, aquí se busca reconstruir la actividad de medición, planteada en relación de analogía con la “imaginación deliberativa”, a la luz de procedimientos de descomposición y recomposición de figuras geométricas, muy difundidos en los siglos V-IV a.C., de los cuales se presentan también ilustraciones numismáticas. En la misma línea se puede situar tanto la referencia de Ética Nicomáquea, III, 5, 1112b20-21 al “análisis” de las figuras, como el de Ética Nicomáquea, VI, 9, 1142a23-29 al triángulo como “extremo”. A este modelo metrético-espacial de la phantasia bouleutikē se añade uno de tipo logístico-temporal, que es mencionado en De anima, III, 7, 431b7-8 y en De memoria, 2, 453a15-16, con una interesante confirmación en Tucídides, I, 138, 3, donde Temístocles es comparado con un “habilísimo gnōmōn”. En ambos casos, los modelos matemáticos en los que se inspira el hombre que imagina mientras trata de comprender qué es obrar bien, aquí y ahora, no son productos refinados de ciencia teórica, sino que pertenecen a aquellas “matemáticas de los mercaderes”, que Platón desaconsejaba practicar para alcanzar la visión del verdadero bien La reseña no presenta resumen.
El eterno retorno del mito. Prolegómenos de una filosofía transespeculativa del mito
Authors: Albizu Edgardo
Published: September 2022

En este escrito, el mito se presenta como sistema a priori de la conciencia en tanto definida por la significancia. Primero se muestra la maduración de la conciencia mítica en los sistemas del logos, hasta llegar a la filosofía de la mitología de la vejez de Schelling. Después se exponen dos líneas posteriores de pensamiento: 1) histórico-fenomenológica (ejemplo: Kerényi); 2) ontológico-existencial (ejemplo: Gusdorf). Por fin, el autor expone su teoría del mito en tanto sistema permutante de religión y ciencia, dialécticamente unificados con su contrapolo: el lenguaje. El trabajo alcanza así su síntesis en la fórmula devenir-lenguaje el mito y devenir-mito el lenguaje.
El James de Putnam
Authors: Calcaterra Rosa M.
Published: September 2022

El presente trabajo busca reconstruir la posición de Hilary Putnam en torno a la filosofía de James, analizando los aspectos que han contribuido principalmente a la evolución del realismo putnamiano. Luego de precisar la afinidad entre Wittgenstein y James que guía el interés de Putnam por el pragmatismo de James, la autora recorre los temas éticos, epistemológicos y metafísicos a partir de los cuales surgen los aspectos más fructíferos de la filosofía pragmatista. Algunos de ellos son: la conjunción entre antidogmatismo y antiescepticismo, la concepción procesal del conocimiento y de la verdad, la crítica al reduccionismo fisicalista y al realismo del sentido común, y, por último, la tesis de la importanciade la dimensión práctica en el desarrollo del análisis filosófico. Queda así subrayada la actualidad de la batalla jamesiana contra la lógica dicotómica que gobierna nuestra tradición teorética.
Sentido modal de la evidencia en Husserl: modalidad versus modalización
Authors: Anton Ivana
Published: September 2022

La evidencia fenomenológica ha sido caracterizada como cumplimiento de una intención mentante, comprensión que tiende a asimilar la evidencia con la conciencia plena, sin hacer justicia a la esencial implicancia mutua de vacío y plenitud que la constituye por su carácter horizóntico-intencional. El horizonte, configurado típicamente, ofrece el campo de cumplimiento posible, por lo que puede sostenerse que la evidencia tiene lugar en una conciencia de posibilidad, es decir, modal, aunque en sentido originariamente material y no dóxico o posicional, pues es el primero el que compete a las relaciones de cumplimiento. La modalidad que caracteriza esencialmente a la evidencia no se revela entonces en la modalización posible en cuanto modificación posicional de un contenido unitario, sino en su configuración material “perfilada” de plenitud y vacío que da algo como algo remitiendo a otras posibilidades como momentos de su propia validez.
Antimicrobial Resistance Pattern of Salmonella Species Recovered from Livestock and Poultry
Authors: Kolhe R.P. , Waskar V.S. , Mehere P.V.
Published: September 2022

Background: Non-typhoidal Salmonellae (NTS) are the predominant source of foodborne Salmonellosis in humans. Livestock and poultry are important reservoirs of NTS. In the context of food safety, this study was undertaken to characterize Salmonella species isolated from livestock, poultry and fish for antimicrobial resistance. Methods: A total of 620 fecal and food samples were randomly collected from different places. Isolation and identification of Salmonella species were done employing microbial and molecular tests. Phenotypic AMR pattern was studied as per the CLSI guidelines and AMR genes were detected by PCR. Result: Salmonella spp. were detected in 39(6.29%) out of 620 samples. Salmonella isolates were 100% sensitive to aztreonam, cefepime, cefpodoxime, followed by cefoxitin (97.43%), ceftazidime (94.43%), piperacillin/tazobactam (94.87%) and ciprofloxacin (71.79%). However, resistance to ampicillin (53.84%), colistin (66.66%), tetracycline (58.57%), amoxyclav (33.33%) and sulfafurazole (23.07%) was observed. Out of 39 isolates, 7(17.94%) were ESBL positive strains and blaTEM was detected in the two ESBL positive isolates. Quinolone- resistant QnrS gene was present in 3(7.69%) isolates. KPC, AmpC and MBL positivity and genes encoding mobile colistin resistance (mcr) were not detected. The presence of virulent and drug-resistant strains of Salmonella in livestock and poultry may poses environmental, food safety and public health risks.
Medicinal Plants: The Rising Strategy for Synthesis of Modern Medicine
Authors: Jindal Arpit . , Seth Chandra Shekhar
Published: September 2022

The knowledge of the medicinal properties of the plants is rooted back in the cultural transmission of historic traditions, and beliefs of the inhabitants of a given geographical area, and in the ancient texts, literature such as Ebers Papyrus, De Materia Medica. The ethnic communities such as Bhotiya residing in the Byans valley of West Himalaya, India; Chin indigenous group of Myanmar still customize their herbal formulations from different plant parts depending upon the types of disease for disease prevention and treatment. However, with the change in consumer behavior, the pharmaceutical industries are gaining interest in the formulation of modern medicines based upon natural plant extracts, or the isolated bioactive compounds.
Lithology of karst deposits of the Uppen Visean section of the Zalesskaya area (North-Western part of the Orenburg region, Russia)
Authors: Boyarshinova M. , Kalina R.
Published: September 2022

Poorly studied deposits of the Upper Visean section of the south-east of the Orenburg region are one of the promising objects of geological exploration. A powerful stratum of dolomite breccias is described in one of the wells of the Zalesovo area in the lower part of the undifferentiated the Venev, Mikhaylov and Aleksino strata of the Visean section. The section is composed of secondary dolomites with relics of primary textures and structures. Dolomitization complicates interpreting the genesis of deposits and conduct detailed sedimentological studies. Lithotypes of rocks are identified based on the analysis of a set of data from lithological and mineralogical studies. Lithotypes: 1) secondary dolomites with relics of primary textures, 2) dolomite breccia with clay-carbonate cement, 3) secondary breccia dolomites with relics of primary textures, 4) dolomite breccia. A detailed lithological description of the lithotypes is given. The features of their formation are determined. Reservoir properties of rocks are analyzed. It has been established that the sediment complex encountered in the section of the Uppen Visean section of the Zalesovo area are the result of different stages of karst formation and following transformation of rocks. Reservoir properties of rocks depend on the development of post-sedimentation transformations. Karst processes and their products require further study at the regional level and consideration when conducting geological exploration on productive reservoirs of the Uppen Visean section.
Przymiotniki relacyjne z sufiksem -sk(i)/-ск(и) w języku polskim i macedońskim. Analiza konfrontatywna
Authors: Stryszewska Maria
Published: September 2022

The paper is devoted to the issue of the derivation of denominal adjectives with suffixal formatives -sk(i)/-ск(и) in Polish and Macedonian. In both of the analysed languages this type is highly productive, but in Macedonian it has significant advantage over the other formatives. In the foreground there is contextual significance of the derivatives. As the most adequate model of description for relational adjectives and for contrastive analysis I find the one proposed by Krystyna Kallas in Grammar of Contemporary Polish Language: Morphology, which consists of relationships between the derivative and the noun it determines. Most of the denominal adjectives with formative -sk(i)/-ск(и) have general meaning “related to what is named by the base noun”; hence, it is possible to specify the meaning of the derivatives only in contextual use. The research leads to the conclusion that the contextual significance depends mainly on the semantics of the word-formation base.
Interpunkcja i składnia w pracach studentów pedagogiki — norma i uzus
Authors: Bortliczek Małgorzata
Published: September 2022

The paper focuses on the ignoring of selected punctuation standards in texts prepared by pedagogy students at the University of Silesia. The analysis includes the description of some punctuation experiences, such as not using essential commas for separation, among others, of subordinate sentences (and/or participial sentence equivalents), interconnected with the superior sentence; separation of the subject group and the predicate group with a comma (as a consequence of following a prosody in the distribution of commas); irregular normative policy (as a consequence, among others, of ignorance of punctuation enumeration). The conclusion highlights didactic and normative recommendations in terms of modern Polish punctuation. It includes the necessity to record, register and analyse new punctuation tendencies in texts written in Polish, such as the ignorance of selected punctuation standards, and the turn towards secondary orality, following the impact of English punctuation.
Везе из старине између Пољака и Срба. Како се принцеза Бањалука вратила у Бању Луку
Authors: Savić Aleksandra , Jakubjec-Semkovova Milica
Published: September 2022

This paper presents the relationship between Serbs and Poles, basing on The Story of Princess Banjaluka, as well as the result of the earliest cultural and historical contacts of the two Slavic peoples. We will introduce the discovery of the story, the relationship between the nations, possible historical sources of the story, and the author. Also, we will present some information about the eponym ”banialuka,” interesting facts regarding this translation, and translation choices made during the preparation of the book.
O zapomnianej czeskiej prowincji. Próba krytycznej refleksji nad filmem „Mistři” Marka Najbrta
Authors: Żygadło-Czopnik Dorota
Published: September 2022

In this article, we introduce readers to the works of the Czech director Marek Najbrt, unknown in Poland, using the example of the film Mistři (2004, Champions). The artist in his work tells about unemployment, contemporary national myths, illusions, love, and hockey. It is a movie addressing issues of Czech national identity, mentality, and the situation in which the Czechs found themselves after 1989. After fifteen years of experience with political independence, market economy, openness to the world, providing new challenges, and enabling comparisons and recapitulation, the artist takes up a story, created from fragments of the history of the “abandoned” inhabitants of certain devastated border areas. In the reflection on the Czech director’s work, we will pay attention to the message about the features of “forbidden narratives” and previously unnoticed narratives. The discourse on the Czechs and Czechness presented in Champions is also developed through the specific creation of film space and applying specific meanings to it (or resulting from it). The authors of the script offered the viewers a bitter tragicomedy about emotional emptiness and human littleness.
Lateral abdominal wall reconstruction
Authors: Smith J. Michael , Kapur Sahil K. , Mericli Alexander F. , Baumann Donald P. , Butler Charles E.
Published: September 2022

Lateral abdominal wall (LAW) defects are defined as hernias, bulges, or surgical wounds that occur within the anatomic region bounded by the linea semilunaris, costal margin, iliac crest, and paraspinous musculature. Reconstruction of the LAW is complicated by the relatively complex anatomy, asymmetric biomechanical forces on the repair, and progressive nature of concomitant denervation injuries. Furthermore, the relative rarity and varied nature of these defects have complicated comparative analysis and the development of consensus regarding optimal surgical management. Although mesh reinforcement of LAW defects is a universal component of available repair techniques, significant variation exists regarding mesh material selection, anatomic plane utilization, and extent of mesh reinforcement. Special consideration must be given to extirpative defects that extend beyond the aforementioned boundaries of the LAW. In this review, we outline the incidence of LAW defects, pertinent risk factors, common history and physical examination findings, supplementary diagnostic modalities, defect classification systems, surgical indications, and available repair techniques. The outcomes data in this review are presented to help guide surgical management and optimize outcomes for affected patients.
Two-Stage Revision Total Knee Arthroplasty for Chronic Histoplasma Capsulatum Prosthetic Joint Infection
Authors: Williams Brady T. , Hogan Craig , Damioli Laura
Published: September 2022

Case:

This report describes a histoplasma capsulatum total knee prosthetic joint infection (PJI) in an immunosuppressed patient treated with a 2-stage revision. The diagnosis of PJI was made based on minor criteria, and the causative organism was identified from cultures obtained at the time of explantation. The patient underwent induction with amphotericin B, followed by oral antifungal therapy and a successful 2-stage revision with a hinged prosthesis with an interval of ∼7 months between stage 1 and stage 2. At the most recent follow-up (18 months), she remained clear from infection with planned lifetime antifungal suppression

Conclusion:

This case report highlights the importance of consideration of atypical organisms when treating immunocompromised patients. Furthermore, this case report documents one of the few cases of histoplasma PJI and provides a successful treatment algorithm to potentially be applied to future cases.
Recurrent Iliopsoas Abscesses Due to Migrated Appendicular Fecalith
Authors: Nagai Sota , Hachiya Kurenai , Takeda Hiroki , Kawabata Soya , Ikeda Daiki , Tsukamoto Tetsuya , Kaneko Shinjiro , Fujita Nobuyuki
Published: September 2022

Case:

Appendicular fecaliths have been reported to migrate to nearby organs before or during surgical treatment and become a late source of infection. We report an extremely rare case of recurrent iliopsoas abscesses caused by appendicular fecaliths that have migrated to the psoas muscle before or during the previous appendicectomy for acute appendicitis. In this case, surgical removal of fecaliths cured the iliopsoas abscess.

Conclusion:

Orthopaedic surgeons and gastroenterologists should remember that appendicular fecaliths that migrated into the iliopsoas muscle may cause late-onset iliopsoas abscesses.
Ultrasound-Guided Needle Aspiration of Subperiosteal Abscess in a Child with Acute Osteomyelitis of the Fibula
Authors: Kanamoto Takashi , Mazuka Takeo
Published: September 2022

Case:

An 8-year-old boy with left lateral ankle pain was diagnosed with acute osteomyelitis after methicillin-susceptible Staphylococcus aureus was identified in a subperiosteal abscess in the distal fibula that had been aspirated using an ultrasound-guided needle. Symptoms improved after 2 weeks of intravenous and 4 weeks of oral antimicrobial therapy; no additional treatment was required. No growth retardation or sequelae were observed at the 6-year follow-up.

Conclusions:

In acute osteomyelitis, the identification of subperiosteal abscess is key for early diagnosis. Ultrasound evaluation of the distal fibula should also be considered in the diagnosis of lateral ankle pain in children.
Anemia and Hemoglobin Level in Angamis Children of Kohima District, Nagaland
Authors:   Research Scholar, Department of Anthropology, Professor of Human Development, Department of Food Science and Nutrition, University of Mysore, Mysuru, Karnataka 570006 India., Thirah Azhole , Gangadhar M R ,   Professor and Chairman, Department of Anthropology, Professor of Human Development, Department of Food Science and Nutrition, University of Mysore, Mysuru, Karnataka 570006, India.
Published: September 2022

The present study has been undertaken to estimate the hemoglobin content with the aim to find out the different levels of hemoglobin content among the Angami children (between 6-10 years) of Jotsoma, Kohima district, Nagaland. A total of 100 blood samples was collected from the children of various houses in different areas of the Jostoma village, Kohima district, Nagaland. Major percentage of children were normal and few under the category of moderate and mild. The boys and girls can equally have grouped into the same state of hemoglobin concentration, but no single girl found to be anemic in the age group of 6 and 10 years. However, more number of boys were anemic than girls.
A Review on Tannase and its Applications
Authors:   Lecturer, Department of Biotechnology and Microbiology, Shri Maneklal M Patel Institute of Science and Research, Kadi Sarva Vishwavidyalaya, Gandhinagar 382015 Gujarat, India., Tripathi Archana , Lakshmi B ,   Assistant Professor, Department of Biotechnology and Microbiology, Shri Maneklal M Patel Institute of Science and Research, Kadi Sarva Vishwavidyalaya, Gandhinagar 382015 Gujarat, India.
Published: September 2022

of tannin and is converted to gallic acid and glucose. Natural tannins occur in various parts of plants such as leaves, roots, bark and fruits. Tannins are distributed in animals, insects and microorganisms. However, microbial tannase is one of the great attention in many industries. Gallic acid is one of the industrial and therapeutic molecules that is widely used in various applications. Tannase is also applicable in feed, pharmaceutical, brewing, chemical and beverage industries. Furthermore, tannase plays a significantly important role in biodegradation or reduction of tannin from the tannery effluent. The present review apprises a brief description of tannase and its industrial applications.
SUPPLIER SELECTION FOR IMPROVING SUPPLY CHAIN PERFORMANCE
Authors: Rohmanna Novianti Adi , Santoso Imam , Majid Zuliyan Agus Nur Muchlis
Published: September 2022

Supplier selection played a role in developing industry performance. It was one of the critical issues in supply chain management. This study illustrated applying a decision-making procedure for supplier selection on KUD Dau Batu by ANP and fuzzy TOPSIS. Four suppliers (Princi, Gading Kulon, Petung Sewu, and Kucur) thought qualified for procuring milk. The first step determined the weight of criteria and sub-criteria that impacted strategic supplier selection by ANP. This approach in a KUD Dau Batu showed that cost was the top priority. The next step was to defuzzification of criteria and ranking the four suppliers by fuzzy TOPSIS. The supplier from Kucur was the best milk supplier compared to other supplier.
Analisis mikrobiologi dan organoleptik mi basah hasil formulasi dengan penggunaan ekstrak bunga telang (Clitoria ternatea L.) sebagai pengawet alami dan antioksidan
Authors: Handayani Nurul Esti , Kumalasari Ika Dyah
Published: September 2022

Clitoria ternatea is a promisiing material to as one of natural preservatives because it contains tannin compounds, carbohydrates, saponins, anthocyanins, flavonoids that has function as antibacterial and antioxidants. This study aims to determine the organoleptic and microbiological properties of wet noodle of Clitoria ternatea extract with various concentrations. This study used a completely randomized design (CRD) consisting of 4 formulations P1 (without extract), P2 (12,5 ml), P3 (25 ml), and P4 (37,5 ml). All formulations were carried out by organoleptic analysis with parameters of color, aroma, taste, hardness, stickiness, elasticity, and overall, then wet noodles with storage treatment of 0 hours, 12 hours, and 24 hours were subjected to microbiological tests. Wet noodles with the most preferred formulation at 0 hours, 12 hours, and 24 hours storage were subjected to chemical analysis tests. Wet noodles with data were analyzed by Analysis of Variance (ANOVA). If there is a significant difference between the treatments, it is continued with Duncan's test. The results showed that wet noodles with highest hedonic score ranged between 3.14-3.80 at 1-5 scale for color, aroma, taste, stickiness, elasticity, and texture was made using 25 ml butterfly pea extract indicated its preferability. This wet noodles proximate content also change during storage correlated to microbiological characteristics. The higher butterfly pea extract concentration, the higher bacteria growth inhbition capacity. Addition of butterfly pea extract had 63.07 % antioxidant activity. The result indicated that butterfly pea extract addition to wet noodles was preferable increased noodles shelf life while inhibited bacteria and fungi growth better than control, thus had potential as natural preservative for wet noodles
FAKTOR-FAKTOR YANG MEMPENGARUHI PENYALURAN KREDIT PERBANKAN PADA BANK UMUM DI INDONESIA PERIODE 2010-2018
Authors: Hardianti S Verdina , Wahyuningsih Diah
Published: September 2022

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi Penyaluran Kredit Perbankan Bank Umum di Indonesia Periode 2010-2018. Variabel independen yang dianalisis yaitu Dana Pihak Ketiga (DPK), Capita Adequacy Ratio (CAR), dan Non Performing Loan (NPL). Metode analisis data yang digunakan ada Error Correction Model (ECM). Periode penelitian yang digunakan adalah bulanan dari Januari-Desember tahun 2010-2018. Hasil penelitian menunjukkan bahwa: DPK mempunyai pengaruh positif signifikan dalam jangka panjang. Sedangkan dalam jangka pendek mempunyai pengaruh positif tidak signifikan. CAR dalam jangka panjang dan jangka pendek tidak mempunyai pengaruh yang signifikan terhadap penyaluran kredit. NPL mempunyai pengaruh negatif signifikan terhadap penyaluran kredit pada bank umum dalam jangka panjang dan mempunyai pengaruh negatif tidak signifikan dalam jangka pendek. Secara simultan DPK, CAR dan NPL berpengaruh signifikan terhadap penyaluran kredit pada bank umum dengan nilai probabilitas F-statistik dibawah taraf signifikan
ANALISIS KOMPARASI STRATEGI PENGEMBANGAN UMKM MEBEL SKALA MIKRO DENGAN SKALA KECIL/MENENGAH (STUDI KASUS PADA UMKM MEBEL DI DESA WRINGINPITU, KECAMATAN MOJOWARNO, KABUPATEN JOMBANG)
Authors: Khoiroh Fita Yatimatul , Indahsari Kurniyati
Published: September 2022

Penelitian ini bertujuan untuk mengetahui komparasi strategi pengembangan usaha mebel skala mikro dengan skala kecil/menengah di Desa Wringinpitu, Kecamatan Mojowarno, Kabupaten Jombang. Metode yang digunakan dalam penelitian ini yaitu metode kualitatif dengan menggunakan analisis pengelompokkan strategi teridentifikasi sesuai dengan konsep pada analisis SWOT dan analisis Komparatif untuk mengkomparasikan strategi. Data yang digunakan berupa data primer hasil wawancara dan dokumentasi terhadap 10 pelaku usaha mebel skala mikro dan 10 pelaku usaha mebel skala kecil/menengah yang dipilih secara purposive. Uji validitas data dengan menggunakan triangulasi sumber. Hasil penelitian menunjukkan bahwa terdapat perbedaan strategi antara pengusaha mebel skala mikro dengan skala kecil/menengah. Strategi pengembangan yang dilakukan oleh pengusaha mebel skala mikro cenderung pada strategi bertahan yaitu meminimalkan kelemahan untuk mencegah ancaman yang dilakukan dengan mengembangkan mebel secara mandiri tanpa mengharap bantuan dari pemerintah setempat. Sementara itu, strategi pengembangan yang dilakukan oleh pengusaha skala kecil/menengah cenderung pada strategi meminimalkan kelemahan untuk memanfaatkan peluang dengan melakukan pinjaman ke Bank ketika terjadi keterbatasan modal dalam proses produksi.
PENGARUH IMPOR, NILAI TUKAR RUPIAH, DAN UTANG LUAR NEGERI TERHADAP CADANGAN DEVISA INDONESIA
Authors: Amalia Siti , Titik Crisanty Sutristyaningtyas
Published: September 2022

Penelitian ini bertujuan untuk mengetahui serta menganalisis seberapa besar pengaruh dari impor, nilai tukar rupiah (kurs), dan utang luar negeri terhadap cadangan devisa Indonesia pada tahun 1986-2018. Penelitian ini menggunakan data sekunder yang diperoleh dari website resmi Bank Indonesia dan World Bank yang berjumlah 33 tahun. Dari hasil uji Metode analisis Error Correction Model (ECM) dengan menggunakan alat bantu Eviews 6. Dalam jangka pendek Impor dan Nilai Tukar Rupiah (Kurs) tidak berpengaruh terhadap Cadangan Devisa, sedangkan Utang Luar Negeri berpengaruh positif terhadap Cadangan Devisa. Dalam Jangka Panjang Impor, Nilai Tukar Rupiah (Kurs), dan Utang Luar Negeri berpengaruh positif terhadap Cadangan Devisa di Indonesia.Kata Kunci : Impor, Nilai Tukar Rupiah (Kurs), Utang Luar Negeri, dan Cadangan Devisa Indonesia.
Pengaruh E-Service Quality Terhadap Loyalitas Pelanggan Grabfood Di Kabupaten Lamongan
Authors: Alfina Pretty , Mada Yudhi Prasetya
Published: September 2022

This study aims to analyze the effect of E-Service Quality on Customer Loyalty of GrabFood Service Feature Users (Study on GrabFood Customers in Lamongan City). The sample that has been used in this study was 100 respondents using purposive sampling technique. The data has been analyzed using SPSS with SPSS 26 software. The results of the study show that partially there is a significant effect of the E-Service Quality variable on the loyalty of the Lamongan City GrabFood customers, simultaneously the E-Service Quality variable, both have a significant effect on the Lamongan City GrabFood Customer loyalty
CRIMINAL CONVICTION OF CHILD TRAFFIC OFFENDERS REVIEWED FROM THE JUVENILE CRIMINAL JUSTICE SYSTEM
Authors: Syafi’i Muhammad Dzikri Akbar , Pribadi Firman Arif , Abdullah Saiful
Published: September 2022

Law Number 11 of 2012 concerning the Juvenile Criminal Justice System (hereinafter referred to as the SPPA Law) which is a formal criminal law for children specifically regulates punishment that can be imposed on children. The criminal sanctions stipulated in the SPPA Law are different from the criminal sanctions in the Criminal Code. The criminal sanctions contained in Article 71 do not include criminal sanctions of confinement and criminal sanctions of fines, nor does the SPPA Law specifically regulate criminal sanctions in lieu of imprisonment and fines. This is a problem related to children who commit criminal acts of traffic violations which in material law are threatened with imprisonment and fines. In this case, the criminal sanctions that can be imposed on children perpetrators of traffic violations are criminal sanctions contained in the SPPA Law by taking into account the principle of the best interests for children, as well as the regulations contained in the SPPA Law. The research method used in this study is a normative juridical research method, with a statute approach and a conceptual approach. The collection of sources of legal materials, both primary and secondary, is carried out through legal literature studies, recording legal documents, laws and regulations and tracing the research results of others. The results of this study show that the criminal sanctions that can be imposed on children violating traffic crimes under the SPPA Law are criminal sanctions for warning, probation, and job training.
A Novel Queueing Access Scheme with Variable Service Probability for Multiple Access Applications
Authors: Liao Chien-Hsing , Woo Tai–Kuo , Guo Ren–Rong
Published: September 2022

Queueing access systems have many applications in daily life, industry, and technology, i.e., bank counter, supermarkets, parts process, router, CPU scheduling, I/O access arrangements, etc. When multiple services are required to match the level of demand for a limited access resource, a multitasking server is needed to release the queueing access problems. In this paper, a multiple queueing access scheme with both fair and enhanced throughput characteristic is available, which can avoid both service conflicts for more throughputs and meet fair service opportunity for each user simultaneously. The proposed scheme represented as M/M/1*/∞ with multiple virtual servers (superscript with 1*) will also provide flexibility for arranging VSPs for users with priority or specific quality of services. Moreover, the proposed scheme will be also exemplified, formulated, and compared with conventional M/M/1/∞ queuing access approach. The system performance and characteristics are also presented with the specified queuing parameters and VSP. It shows that the expected probability and user number in service (not in queue) are enhanced with the proposed scheme.
WITHDRAWN: Efficient Modified Slice Handover Algorithm for 5G Wireless Networks
Authors: A AZHAGU JAISUDHAN PAZHANI , GUNASEKARAN P
Published: September 2022

The goal of 5G wireless networks is to address the growing need for network services among users. User equipments have progressed to the point where they now expect diverse services from the network. The latency, reliability, and bandwidth requirements of users can all be classified. 5G systems are planned to leverage technologies like Software Defined Networks, Network Function Virtualisation and Network Slicing to fulfil the different needs of users in an economical manner while guaranteeing network resources are resourcefully assigned to consumers. For the purpose to ensure continuous handover among network slices, new mobility management techniques must be adopted in Sliced 5G networks with the advent of varied 5G application scenarios. Users can travel from one region of coverage to another region without fading their network connection. Different network slices can coexist in 5G networks, with every slice offering services customised to various QoS demands. As a result, when customers travel from one region of coverage to another, the call can be transferred to a slice that caters to the similar or slightly different requirements. The goal of this study is to develop an algorithm for determining handover decisions in sliced 5G networks and to assess its performance.
Vascular Changes in Chronic Hepatitis C Cirrhotic Patients Treated with Direct Acting Antiviral Agents
Authors: Sieddek Asmaa Salama , Taha Mohamed Kamal , Attia Dina Ismail
Published: September 2022

Egypt has high prevalence of HCV infection. Portal hypertension is a leading cause of morbidity and mortality in patients with liver cirrhosis. Aim of our study evaluating changes of portal circulation by upper GIT endoscopy and gray scale abdominal ultrasound before and after 12 weeks treatment.
Methods Our study is a observational prospective of 150 HCV cirrhotic patients receiving different DAA regimens.
Results showed normalizations of Fibrosis-4 (FIB-4) score among patients after treatment which was statistically significant (p-value <0.001) while, ultrasound Measurements of PV, SMV, SV and Spleen diameter done before and after treatment, follow up period of 6 months with p-value (0.821 0.988, 0.841 ,0.923) respectively, and endoscopic follow up with progression esophageal varices size occurred in 3.7%, new varices incidance occurred in 2.3%, progression of red color signs occurred in 1.9% and 5.4% of patients had an attack of GIT bleeding with varices incidence between naïve and experienced patients (p-value0.395), PHG incidence, before and after treatment (p-value 0.780), without significant difference.
Conclusion HCV treatment improve liver enzymes in cirrhotic patients; however viral eradication did not always mean cure of liver cirrhotic patients on follow up with no statistically significant difference on portal hypertension changes
Efficacy of two different dosages of prednisone for treatment of subacute thyroiditis: a single-center, prospective, randomized, open-label, non-inferiority trial
Authors: Xu Yiqi , Zeng Xiaofan , Liu Shu , Wu Qian , Chen Yueping , He Chunling , Zhai Qing , Zhang Binhua , Gao Jialin
Published: September 2022

Background: The aim of study was to explore the efficacy and safety of low-dose (LD) and regular dose (RD) prednisone (PDN) for treatment of subacute thyroiditis (SAT).
Methods: Patients were randomly allocated using the block randomization method to the two groups. The primary outcome was the time required for PDN treatment. Secondary outcomes included percentages of relapse, mean score for the Morisky Medication Adherence Scale-8©（MMAS-8）, time required for symptoms to resolve, cumulative PDN dose (mg) and mean erythrocyte sedimentation rate (ESR) at 2 weeks and baseline.
Results: The study cohort included 77 patients, randomized 74 participants, and 68 completed the study. There was no significant difference in the treatment duration between the LD and RD groups (55.31±14.05 vs.61.25±19.95 days, p=0.053). The mean difference in the time required for PDN treatment between the LD and RD groups was -1.86 (95%CI =-10.64 to 6.92) days, which was within the non-inferiority margin of 7 days. There was a significant difference in the mean score for MMAS-8 between the LD and RD groups (5.84±0.88 vs.5.40±1.14, p=0.023). Also, there was a significant difference in the cumulative PDN dose between the LD and RD groups (504.22±236.86 vs.1002.28±309.86, p=0.046). The ESR at 2 weeks was statistically significant as compared to baseline values in both groups, with pre-treatment and post-treatment ESRs of 49.91±24.95 and 17.91±12.60/mm/h, (p<0.0001) in the LD group and 65.08±21.77 and 17.23±13.61/mm/h (p<0.0001) in the RD group.
Conclusion: Low-dose PDN therapy may be sufficient to achieve complete recovery and better outcomes of SAT.
This study is registered with Chinese Clinical Trial Registry (02/10/2021 ChiCTR2100051762).
Navigation function for Multi-Agent Multi-Target Interception Missions
Authors: Hacohen Shlomi , Shoval Shraga , Shvalb Nir
Published: September 2022

Missions across a variety of disciplines require the interception of multiple targets. In defence scenarios, targets may pose a threat to sites, while in agriculture the targets may be invasive pests or fruit ready to harvest. This paper focuses on the cooperative control of a robot swarm for interception missions of multiple static and dynamic targets while avoiding collisions. We formulate two modifications of the classical Navigation-Function which are suited for deterministic and stochastic scenarios. Both provide a simultaneous solution for the problems of target assignment and motion-planning as opposed to the classical approaches that solve each problem independently.
We show analytically that by following the Swarm-Navigation-Function gradient, the swarm will intercept all static targets while avoiding agent-agent and agent-obstacle collisions and similarly following the gradient of the Probabilistic-Navigation-Function will almost surely converge to a target in finite time, while the probability for agent-agent and agent-obstacles collisions is limited to a predefined value. The complexity of both schemes is linear with the number of targets and robots, and therefore it is scalable. Although not optimal, these solutions are simple and efficient, making them suitable for an extended set of real-time and real-life applications. We compare the resulting Swarm-Navigation-Function trajectories to that of a human in a catch game and an interception virtual game, the comparison indicates that as the trajectories are similar, human decision-making performs better. We conclude the paper with a set of simulated experiments and real-world experiments demonstrating the efficiency of the proposed scheme for dynamic targets.
LncRNA miR663AHG represses the development of colon cancer in a miR663a expression-dependent negative feedback loop
Authors: Yuan Hongfan , Du Yantao , Ma Yuwan , Gu Liankun , Zhou Jing , Tian Wei , Deng Dajun
Published: September 2022

Background
The MIR663AHG gene encode both miR663AHG and miR663a. While miR663a contributes to the defense of host cells against inflammation and inhibits colon cancer development, the biological function of lncRNA miR663AHG has not been previously reported.
Methods
The subcellular localization of lncRNA miR663AHG was determined by RNA-FISH. miR663AHG and miR663a were measured by qRT-PCR. The effects of miR663AHG on the growth and metastasis of colon cancer cells were investigated in vitro and in vivo. CRISPR/Cas9, RNA pulldown, and other biological assays were used to explore the underlying mechanism of miR663AHG.
Results
miR663AHG was mainly distributed in the nucleus of Caco2 and HCT116 cells and the cytoplasm of SW480 cells. The expression level of miR663AHG was positively correlated with the level of miR663a (r = 0.179, P = 0.015) and significantly downregulated in colon cancer tissues relative to paired normal tissues from 119 patients (P < 0.008). Colon cancers with low miR663AHG expression were associated with advanced pTNM stage (P = 0.021), lymph metastasis (P = 0.041), and shorter overall survival (hazard ratio = 2.026; P = 0.021). Experimentally, miR663AHG inhibited colon cancer cell proliferation, migration, and invasion. The growth of xenografts from RKO cells overexpressing miR663AHG was slower than that of xenografts from vector control cells in BALB/c nude mice (P = 0.007). Interestingly, either RNA-interfering or resveratrol-inducing expression changes of miR663AHG or miR663a can trigger negative feedback regulation of transcription of the MIR663AHG gene. Mechanistically, miR663AHG could bind to miR663a and its precursor pre-miR663a, and prevent the degradation of miR663a target mRNAs. Disruption of the negative feedback by knockout of the MIR663AHG promoter, exon-1, and pri-miR663A-coding sequence entirely blocked these effects of miR663AHG.
Conclusion
miR663AHG functions as a tumor suppressor that inhibits the development of colon cancer through its cis-binding to miR663a/pre-miR663a. The negative feedback loop between miR663AHG and miR663a expression may play dominant roles in maintaining the functions of miR663AHG in colon cancer development.
Evaporated fraction of thujopsene from Thujopsis dolabrata starves cancer cells via PKM2
Authors: Nagata Takuya , Toume Kazufumi , Hashim Yasinjan , Satou Tadaaki , Phan Nguyen Duy , Saeki Shiori , Sukegawa Kenta , Tohda Chihiro , Komatsu Katsuko , Fujii Tsutomu , Watanabe Manabu , Saida Yoshihisa
Published: September 2022

Objective
Many cancer patients need for new treatment options with lower side effects. Herein, we report on the antitumor effect of thujopsene derived from the volatile components of Thujopsis dolabrata (asunaro).
Methods
The antitumor effect of the asunaro essential oil was analyzed using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and in vivo cancer metastasis model. Thujopsene was isolated from asunaro essential oil by liquid chromatography, and the tumor growth inhibitory mechanism of thujopsene was assessed using Western blotting and DARTS (Drug affinity responsive target stability) analysis.
Results
The volatile components of asunaro essential oil exhibited an antitumor effect on MCF7 and SKBR3 breast cancer cells as well as on MKN45 gastric and DLD1 colon cancer cells. Thujopsene was identified as an antitumor factor that tended to have a stronger tumor growth inhibitory effect. Pyruvate kinase M2 (PKM2) was found to be associated with thujopsene in cancer cells. The reaction of thujopsene with MKN45 cells reduced intracellular lactate production. These results indicate that thujopsene binds to PKM2 in cancer cells and inhibits the nutritional metabolic pathway, and causing apoptosis. In conclusion, thujopsene may suppress tumor growth and metastasis by inhibiting the trophic metabolism pathway of cancer cells.