bluuebunny/crossref_metadata_2025 huggingface dataset:
Monofractal Dimension in Quantifying the Image of Neurons in the Plane: Analysis of Image Features of Multipolar Neurons from the Principal Olivary Nucleus in Humans with Age
Authors: Milošević Nebojša
Published: July 2022

The existing study examines four features of 2D images from the principal olivary nucleus of the adult human. The main goal of the research is to investigate the relationship between monofractal and computational parameters that quantify three features of neuronal images. An additional goal of the research is to examine the change in the four features of the image with age. The samples belonged to the histological collection from the Department of Anatomy of the University of Novi Sad. From the pool of binary images, a sample of medium-sized neurons was selected and further processed. A public computer program (Image J with FracLac plugin) with standard commands that calculate computational and monofractal parameters analyzed all images. The relationship between parameters or between parameters with age was performed by statistical evaluation of Pearson’s correlation coefficient. The monofractal dimension of corresponding images can qualitatively represent image properties and some features decrease with age, while some do not. This study confirms the previous conclusions according to which the monofractal dimension of neuronal image reliably quantifies three features of the image. On the other hand, the study shows the distribution of four features with age.
Complete Nucleotide Sequence of the Mitogenome of Tapinoma ibericum (Hymenoptera: Formicidae: Dolichoderinae), Gene Organization and Phylogenetics Implications for the Dolichoderinae Subfamily
Authors: Ruiz-Mena Areli , Mora Pablo , Montiel Eugenia E. , Palomeque Teresa , Lorite Pedro
Published: July 2022

The ant Tapinoma ibericum Santschi, 1925 is native to the Iberian Peninsula. This species, as well as other species from the Tapinoma nigerrimum complex, could form supercolonies that make these species potentially invasive and could give rise to pests. Recently a mature colony from this species has been found in the Isle of Wight (United Kingdom). Mitogenomes have been used to study the taxonomy, biogeography and genetics of species, improving the development of strategies against pest invasion. However, the number of available mitogenomes from the subfamily Dolichoderinae is still scarce and only two of these mitogenomes belong to Tapinoma species. Herein, the complete mitogenome of T. ibericum is presented in order to increase the molecular information of the genus. The T. ibericum mitogenome, retrieved by Next-Generation Sequencing data, is 15,715 bp in length. It contains the typical set of 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNAs and the A + T-rich control region. Comparisons of the T. ibericum mitogenome with other dolichoderine mitogenomes revealed the existence of four gene rearrangements in relation with the ancestral insect mitogenome. One of these rearrangements, involving the tRNA-Ile, tRNA-Gln and tRNA-Met genes, was found in most of the analyzed ant mitogenomes. Probably this rearrangement was an ancestral or plesiomorphic character in Formicidae. Interestingly, another rearrangement that affects to tRNA-Trp, tRNA-Cys and tRNA-Tyr genes was found only in Tapinoma species. This change could be a synapomorphic character for the genus Tapinoma, and could be used as a phylogenetic marker. Additionally, a phylogenetic analysis was performed using the protein-coding gene sequences from available Dolichoderinae mitogenomes, as well as mitogenomes from representative species from other Formicidae subfamilies. Results support the monophyletic nature of the genus Tapinoma placing it within the same clade as the rest of Dolichoderinae species.
Characteristics, Kinematics and Contributing Factors of Compound and Translational Landslides in the Interior Plains of Canada
Authors: Biagini Luiz , Macciotta Renato , Gräpel Chris , Tappenden Kristen , Skirrow Roger
Published: July 2022

Understanding landslide kinematics, their characteristics, and contributing factors is crucial for decision-making regarding mitigation strategies for infrastructure projects. These characteristics depend on the geomorphology of the area, climate, and proximity to water bodies and anthropogenic activity. Some geomorphological features are shared between some western Canadian regions, particularly within the Canadian Interior Plains (Interior Plains). This paper synthesizes the failure mechanisms, kinematics, triggering events, and contributing factors associated with 11 landslides in the Interior Plains, with detailed qualitative descriptions of two of them. The paper discusses the commonalities of bedrock formations that contain thin sub-horizontal and continuous deposits of weak materials as the main geomorphological predisposing factor for landslides in this region. The findings show commonalities in the effect of seasonal fluctuations in the characteristics of water bodies in contact with these landslides, driving episodes of landside reactivation, acceleration and deceleration. Importantly, anthropogenic activity as a trigger for the initiation of some of these landslides suggests a high susceptibility of certain slopes in the Interior Plains to instability resulting from relatively small changes in in-situ stresses. This information becomes critical for assessing the landslide susceptibility of valley slopes in this region for infrastructure planning, design, and operation.
The Effects of Pandemic Restrictions on Public Health—Improvements in Urban Air Quality
Authors: Cioca Gabriela , Nerişanu Raluca Andreea
Published: July 2022

The present study aims to provide evidence on the effects of pandemic curtailment measures on public health, targeting the changes in breathable air quality, within urban areas. The analyzed period covers the full impact of lockdowns in Europe in 2020. We used everyday data for each analyzed pollutant, NO2, SO2, CO, PM2.5 and PM10, from urban monitoring stations that provided real-time concentrations (provided by Copernicus Atmosphere Monitoring Service, Environmental Protection Agency repository and European Environment Agency map services) and satellite data (provided by NASA Orbiting Carbon Observatory 2). In the present study, the urban air quality was computed using a composite index that was further analyzed in comparison with pandemic restrictions. Descriptive statistics, charts and maps were used to visualize the data that covered the analyzed countries. Our results show that air pollution was reduced by 12% after lockdowns in European urban areas, with a 0.76 correlation between air pollution and pandemic restrictions. All air pollutants registered significant drops.
“Truly Listen to Us”: Recommendations for Health Professionals to Bolster Wellbeing of Nonbinary Individuals
Authors: Kinney M. Killian , Cosgrove Darren
Published: July 2022

Trans-affirming providers play significant roles in the health and wellbeing of nonbinary individuals. Yet, healthcare mistreatment is well-documented among gender-diverse patients, leading to clients withholding information and avoiding care for fear of experiencing bias. Concurrently, healthcare providers report feeling ill-equipped to serve nonbinary patients, often perpetuating cisnormative binary attitudes. The literature has established the challenges to accessing healthcare and the need for gender-affirming care. However, little is known about nonbinary people’s perspectives on how best to deliver gender-affirming care that is inclusive of nonbinary patients. This participatory action PhotoVoice study identified community member recommendations for healthcare providers to bolster the wellbeing of nonbinary individuals through improved access to gender-affirming healthcare. Data were collected through group discussions, photography, and photo-elicitation interviews. Drawing upon research results, the authors identify recommendations for improving interpersonal care, increasing access to gender-affirming care, and advocating for related environmental and policy changes.
Physiological Health and Physical Performance in Multiple Chemical Sensitivity—Described in the General Population
Authors: Bjerregaard Anne A. , Petersen Marie W. , Skovbjerg Sine , Gormsen Lise K. , Cedeño-Laurent José G. , Jørgensen Torben , Linneberg Allan , Dantoft Thomas Meinertz
Published: July 2022

Multiple chemical sensitivity (MCS) is a multifactorial somatic disorder characterized by physical reactions triggered by even extremely low levels of different airborne chemicals. In most individuals with MCS, these reactions have substantial negative impact on social, occupational, and everyday life often including limited or no engagement in physical activities. The aim of this study was to explore associations between MCS and objective measurements of anthropometry, cardiorespiratory health, and physical performance. From the Danish population-based cohort DanFunD counting 9656 participants aged 18–76 years, 1.95% (n = 188) were categorized as MCS individuals (MCS All). Of those 188, 109 participants were subcategorized as having MCS without functional somatic disorders (FSD) (MCS with no comorbid FSD). The remaining study population without any FSD were regarded controls. We used adjusted multiple linear regression analyses to evaluate associations between MCS and anthropometry, cardiorespiratory fitness, and physical performance. Compared with the general population, MCS All had less optimal body composition, increased risk of obesity, impaired cardiorespiratory fitness, and physical performance which was not seen in MCS with no comorbid FSD. MCS individuals may be inhibited to maintain an active lifestyle which can increase risk of obesity and consequently have negatively impact on general health, which may not be the case among MCS with no comorbid FSD.
Biomechanical Analysis of Stoop and Free-Style Squat Lifting and Lowering with a Generic Back-Support Exoskeleton Model
Authors: Tröster Mark , Budde Sarah , Maufroy Christophe , Andersen Michael Skipper , Rasmussen John , Schneider Urs , Bauernhansl Thomas
Published: July 2022

Musculoskeletal disorders (MSDs) induced by industrial manual handling tasks are a major issue for workers and companies. As flexible ergonomic solutions, occupational exoskeletons can decrease critically high body stress in situations of awkward postures and motions. Biomechanical models with detailed anthropometrics and motions help us to acquire a comprehension of person- and application-specifics by considering the intended and unintended effects, which is crucial for effective implementation. In the present model-based analysis, a generic back-support exoskeleton model was introduced and applied to the motion data of one male subject performing symmetric and asymmetric dynamic manual handling tasks. Different support modes were implemented with this model, including support profiles typical of passive and active systems and an unconstrained optimal support mode used for reference to compare and quantify their biomechanical effects. The conducted simulations indicate that there is a high potential to decrease the peak compression forces in L4/L5 during the investigated heavy loaded tasks for all motion sequences and exoskeleton support modes (mean reduction of 13.3% without the optimal support mode). In particular, asymmetric motions (mean reduction of 14.7%) can be relieved more than symmetric ones (mean reduction of 11.9%) by the exoskeleton support modes without the optimal assistance. The analysis of metabolic energy consumption indicates a high dependency on lifting techniques for the effectiveness of the exoskeleton support. While the exoskeleton support substantially reduces the metabolic cost for the free-squat motions, a slightly higher energy consumption was found for the symmetric stoop motion technique with the active and optimal support mode.
The Benefits of an Employee-Friendly Company on Job Attitudes and Health of Employees: Findings from Matched Employer–Employee Data
Authors: Herr Raphael M. , Brokmeier Luisa Leonie , Fischer Joachim E. , Mauss Daniel
Published: July 2022

Background: This study explored the association of an employee-friendly work environment with employees’ job attitudes (engagement, commitment, turnover intentions, and job satisfaction), and health (mental and general health), applying matched employer–employee data. Methods: The German Linked Personnel Panel (LPP; n = 14,182) survey simultaneously captures the data of employees and the human resources (HR) management of companies. A two-step cluster analysis of 16 items of the HR valuation identified relatively more- and less-employee-friendly companies (EFCs). Logistic regressions tested differences between these companies in the assessment of job attitudes and health of their employees. Results: Compared to less-EFCS, more-EFCS had a reduced risk of poorer job attitudes and substandard health of their employees. For example, the risk for higher turnover intentions was reduced by 33% in more-EFCS (OR = 0.683, 95% C.I. = 0.626–0.723), and more-EFCS had an 18% reduced chance of poor mental health reporting of their employees (OR = 0.822, 95% C.I. = 0.758–0.892). Conclusions: More-EFCS have more motivated and healthier employees. The most distinct factors for more-EFCS were: the existence of development plans for employees, opportunities for advancement and development, and personnel development measures.
Determinants of Delayed Initiation of Breastfeeding: A Cross-Sectional Multicenter Study in Abu Dhabi, the United Arab Emirates
Authors: Taha Zainab , Al Dhaheri Aysha Ibrahim , Wikkeling-Scott Ludmilla , Ali Hassan Ahmed , Papandreou Dimitrios
Published: July 2022

One of the best practices to reduce the risk of infant morbidity and mortality is the early initiation of breastfeeding, specifically within the first hour of birth, as the World Health Organization (WHO) recommends. Limited data exist on breastfeeding initiation and its related factors in the United Arab Emirates (U.A.E.). Therefore, the purpose of this research study was to evaluate and analyze the determinant factors associated with delayed initiation of breastfeeding among mothers with children aged <2 years old in a cross-sectional multicenter setting in Abu Dhabi, U.A.E. Seven governmental community and healthcare centers participated in the study from diverse geographic areas of Abu Dhabi. A trained female research assistant collected information from mothers with young children attending the centers. All participants were informed in detail about the purpose of the study and signed a written consent form. A total of 1610 mother–child pairs were included in the study. The mean (standard deviation) of maternal age and children’s age was 30.1 (5.1) years and 8.1 (5.9) months, respectively. Six hundred and four (604) (37.5%) reported delayed initiation of breastfeeding. Factors associated with delayed breastfeeding initiation were being of non-Arab nationality (adjusted odds ratio (A.O.R.) 1.30, 95% confidence interval (CI) 1.03, 1.63), caesarean section (AOR 2.85, 95% CI 2.26, 3.58), non-rooming-in (AOR 2.82, 95% CI 1.53, 5.21), first birth order (AOR 1.34, 95% CI 1.07, 1.69), and mothers with low-birth-weight children (AOR 3.30, 95% CI 2.18, 4.99) as was analyzed by multivariate logistic regression analysis. In conclusion, approximately four out of ten mothers delayed initiation of breastfeeding for more than one hour after delivery. The results of this study call for urgent policy changes to improve the early initiation rates of breastfeeding mothers in the U.A.E.
Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome
Authors: Abdol Manap Nurliza , Ng Beng Kwang , Phon Su Ee , Abdul Karim Abdul Kadir , Lim Pei Shan , Fadhil Maimunah
Published: July 2022

Endometrial cancer is the sixth most common malignancy in women, and it is known to be a disease among postmenopausal women, but there is rising in the number of endometrial cancers among premenopausal women. This study aims to determine the clinical characteristic, risk factors, outcomes, and survival in pre and postmenopausal women with endometrial cancer in Malaysia. A retrospective study was conducted in Hospital Melaka that involved all women who were diagnosed with endometrial cancer in Hospital Melaka from January 2002 until July 2020. All subjects’ histopathological examination result was confirmed, and their clinical data were extracted and transferred into a standardized data checklist and analysed. A total number of 392 cases was obtained from the Annual Cancer Registry Hospital Melaka. However, only 281 cases were studied, including 44.8% premenopausal and 55.2% postmenopausal women. In the premenopausal group, there were higher incidence of obesity (30.8 + 8.6 vs. 28.9 + 7.1), younger age at menarche (12.7 + 1.5 vs. 13.3 + 1.6), lesser parity (1.47 vs. 3.26), and a higher number of nulliparous women (46.8% vs. 19.4%) as compared to postmenopausal group. The premenopausal group tends to be presented with a well-differentiated grading of tumour (52.4%) and a higher incidence of having concomitant endometrial hyperplasia (41.3%). The mean survival among the premenopausal group (200.3 + 7.9 months) is higher compared to postmenopausal group (153.9 + 6.5 months). These findings correlate with good survival and prognosis among the premenopausal group compared to the postmenopausal group.
Posterior Tibial Nerve Stimulation in Children with Lower Urinary Tract Dysfunction: A Mixed-Methods Analysis of Experiences, Quality of Life and Treatment Effect
Authors: De Wall Liesbeth L. , Bekker Anna P. , Oomen Loes , Janssen Vera A. C. T. , Kortmann Barbara B. M. , Heesakkers John P. F. A. , Oerlemans Anke J. M.
Published: July 2022

Background: Posterior tibial nerve stimulation (PTNS) is one of the treatment modalities for children with therapy-refractory lower urinary tract dysfunction (LUTD). This study used a mixed-methods analysis to gain insight into the experiences of children treated with PTNS and their parents, the effect of treatment on quality of life (QOL) and the effect of PTNS on urinary symptoms. Methods: Quantitative outcomes were assessed through a single-centre retrospective chart analysis of all children treated with PTNS in a group setting between 2016–2021. Voiding parameters and QOL scores before and after treatment were compared. Qualitative outcomes were assessed by an explorative study involving semi-structured interviews transcribed verbatim and inductively analysed using the constant-comparative method. Results: The data of 101 children treated with PTNS were analysed. Overall improvement of LUTD was seen in 42% and complete resolution in 10%. Average and maximum voided volumes significantly increased. QOL improved in both parents and children independent of the actual effect on urinary symptoms. Interviews revealed PTNS to be well-tolerated. Facilitating PTNS in a group setting led to feelings of recognition in both children and parents. Conclusions: PTNS is a good treatment in children with therapy-refractory LUTD and provides valuable opportunities for peer support if given in a group setting.
Dipeptide IF and Exercise Training Attenuate Hypertension in SHR Rats by Inhibiting Fibrosis and Hypertrophy and Activating AMPKα1, SIRT1, and PGC1α
Authors: Ho Jou-Hsuan , Baskaran Rathinasamy , Wang Ming-Fu , Mohammedsaleh Zuhair M. , Yang Hong-Siang , Balasubramanian Balamuralikrishnan , Lin Wan-Teng
Published: July 2022

Bioactive peptides are physiologically active peptides produced from proteins by gastrointestinal digestion, fermentation, or hydrolysis by proteolytic enzymes. Bioactive peptides are resorbed in their whole form and have a preventive effect against various disease conditions, including hypertension, dyslipidemia, inflammation, and oxidative stress. In recent years, there has been a growing body of evidence showing that physiologically active peptides may have a function in sports nutrition. The present study aimed to evaluate the synergistic effect of dipeptide (IF) from alcalase potato protein hydrolysates and exercise training in hypertensive (SHR) rats. Animals were divided into five groups. Bioactive peptide IF and swimming exercise training normalized the blood pressure and decreased the heart weight. Cardiac, hepatic, and renal functional markers also normalized in SHR rats. The combined administration of IF peptide and exercise offer better protection in SHR rats by downregulating proteins associated with myocardial fibrosis, hypertrophy, and inflammation. Remarkably, peptide treatment alongside exercise activates the PI3K/AKT cell survival pathway in the myocardial tissue of SHR animals. Further, the mitochondrial biogenesis pathway (AMPKα1, SIRT1, and PGC1α) was synergistically activated by the combinatorial treatment of IF and exercise. Exercise training along with IF administration could be a possible approach to alleviating hypertension.
Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer
Authors: Scott Emma , Garnham Rebecca , Cheung Kathleen , Duxfield Adam , Elliott David J. , Munkley Jennifer
Published: July 2022

Prostate cancer is the most common cancer in men, and it is primarily driven by androgen steroid hormones. The glycosylation enzyme EDEM3 is controlled by androgen signalling and is important for prostate cancer viability. EDEM3 is a mannosidase that trims mannose from mis-folded glycoproteins, tagging them for degradation through endoplasmic reticulum-associated degradation. Here, we find that EDEM3 is upregulated in prostate cancer, and this is linked to poorer disease-free survival. Depletion of EDEM3 from prostate cancer cells induces an ER stress transcriptomic signature, and EDEM3 overexpression is cyto-protective against ER stressors. EDEM3 expression also positively correlates with genes involved in the unfolded protein response in prostate cancer patients, and its expression can be induced through exposure to radiation. Importantly, the overexpression of EDEM3 promotes radio-resistance in prostate cancer cells and radio-resistance can be reduced through depletion of EDEM3. Our data thus implicate increased levels of EDEM3 with a role in prostate cancer pathology and reveal a new therapeutic opportunity to sensitise prostate tumours to radiotherapy.
Impact of Copper-Doped Mesoporous Bioactive Glass Nanospheres on the Polymerisation Kinetics and Shrinkage Stress of Dental Resin Composites
Authors: Marovic Danijela , Par Matej , Tauböck Tobias T. , Haugen Håvard J. , Negovetic Mandic Visnja , Wüthrich Damian , Burrer Phoebe , Zheng Kai , Attin Thomas , Tarle Zrinka , Boccaccini Aldo R.
Published: July 2022

We embedded copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) with antibacterial and ion-releasing properties into experimental dental composites and investigated the effect of Cu-MBGN on the polymerisation properties. We prepared seven composites with a BisGMA/TEGDMA (60/40) matrix and 65 wt.% total filler content, added Cu-MBGN or a combination of Cu-MBGN and silanised silica to the silanised barium glass base, and examined nine parameters: light transmittance, degree of conversion (DC), maximum polymerisation rate (Rmax), time to reach Rmax, linear shrinkage, shrinkage stress (PSS), maximum PSS rate, time to reach maximum PSS rate, and depth of cure. Cu-MBGN without silica accelerated polymerisation, reduced light transmission, and had the highest DC (58.8 ± 0.9%) and Rmax (9.8 ± 0.2%/s), but lower shrinkage (3 ± 0.05%) and similar PSS (0.89 ± 0.07 MPa) versus the inert reference (0.83 ± 0.13 MPa). Combined Cu-MBGN and silica slowed the Rmax and achieved a similar DC but resulted in higher shrinkage. However, using a combined 5 wt.% Cu-MBGN and silica, the PSS resembled that of the inert reference. The synergistic action of 5 wt.% Cu-MBGN and silanised silica in combination with silanised barium glass resulted in a material with the highest likelihood for dental applications in future.
Translational, Precision, and Personalized Medicine in Gastroenterology
Authors: Candelli Marcello
Published: July 2022

In recent decades, tremendous progress has been made in the medicinal field in understanding the molecular mechanisms underlying human pathologies, due to the significant development of advanced laboratory techniques and technologies [...]
Advances in the Therapeutic Effects of Apoptotic Bodies on Systemic Diseases
Authors: Li Xiaoyan , Liu Yitong , Liu Xu , Du Juan , Bhawal Ujjal Kumar , Xu Junji , Guo Lijia , Liu Yi
Published: July 2022

Apoptosis plays an important role in development and in the maintenance of homeostasis. Apoptotic bodies (ApoBDs) are specifically generated from apoptotic cells and can contain a large variety of biological molecules, which are of great significance in intercellular communications and the regulation of phagocytes. Emerging evidence in recent years has shown that ApoBDs are essential for maintaining homeostasis, including systemic bone density and immune regulation as well as tissue regeneration. Moreover, studies have revealed the therapeutic effects of ApoBDs on systemic diseases, including cancer, atherosclerosis, diabetes, hepatic fibrosis, and wound healing, which can be used to treat potential targets. This review summarizes current research on the generation, application, and reconstruction of ApoBDs regarding their functions in cellular regulation and on systemic diseases, providing strong evidence and therapeutic strategies for further insights into related diseases.
Sustainable Mobility as a Service: Dynamic Models for Agenda 2030 Policies
Authors: Russo Francesco
Published: July 2022

Growth trends in passenger transport demand and gross domestic product have so far been similar. The increase in mobility in one area is connected with the increase in GDP in the same area. This increase is representative of the economic and social development of the area. At the same time, the increase in mobility produces one of the most negative environmental impacts, mainly determined by the growth of mobility of private cars. International attention is given to the possibilities of increasing mobility and, therefore, social and economic development without increasing environmental impacts. One of the most promising fields is that of MaaS: Mobility as a Service. MaaS arises from the interaction of new user behavioral models (demand) and new decision-making models on services (supply). Advanced interaction arises from the potentialities allowed by emerging ICT technologies. There is a delay in the advancement of transport system models that consider the updating of utility and choice for the user by means of updated information. The paper introduces sustainability as defined by Agenda 2030 with respect to urban passenger transport, then examines the role of ICT in the development of MaaS formalizing a dynamic model of demand–supply interaction explicating ICT. Finally, the advanced Sustainable MaaS, defined SMaaS, is analyzed, evidencing the contribution to achieving the goals of Agenda 2030.
Correlation of Lung Damage on CT Scan with Laboratory Inflammatory Markers in COVID-19 Patients: A Single-Center Study from Romania
Authors: Citu Cosmin , Gorun Oana Maria , Motoc Andrei , Citu Ioana Mihaela , Gorun Florin , Malita Daniel
Published: July 2022

(1) Background: This study aims to evaluate the association of CRP, NLR, IL-6, and Procalcitonin with lung damage observed on CT scans; (2) Methods: A cross-sectional study was performed among 106 COVID-19 patients hospitalized in Timisoara Municipal Emergency Hospital. Chest CT and laboratory analysis were performed in all patients. The rank Spearmen correlation was used to assess the association between inflammatory markers and lung involvement. In addition, ROC curve analysis was used to determine the accuracy of inflammatory markers in the diagnosis of severe lung damage; (3) Results: CRP, NLR, and IL-6 were significantly positively correlated with lung damage. All inflammatory markers had good accuracy for diagnosis of severe lung involvement. Moreover, IL-6 has the highest AUC- ROC curve; (4) Conclusions: The inflammatory markers are associated with lung damage and can be used to evaluate COVID-19 severity.
The Narrowed Internal Auditory Canal: A Distinct Etiology of Pediatric Vestibular Paroxysmia
Authors: Idriss Samar A. , Thai-Van Hung , Altaisan Riham , Ltaief-Boudrigua Aicha , Reynard Pierre , Ionescu Eugen Constant
Published: July 2022

Vestibular paroxysmia (VP) is a disorder encountered in the pediatric population that etiology has been attributed to neurovascular cross-compression syndrome (NVCC). The purpose of this study was to report a new probable pathological condition, the narrowed internal auditory canal (IAC), which appears to be involved in the development of a clinical picture of VP in the pediatric population. A retrospective descriptive comparative study was conducted to compare clinical, electrophysiological, radiological, and therapeutic outcomes in both etiologies. Overall, 16 pediatric patients suffering from VP were included and divided into two groups: patients with narrowed internal auditory (Group 1) were compared to those with NVCC syndrome (Group 2). Patients in both groups were similar in terms of auditory complaints, as well as hearing, vestibular, and electrophysiological status. A narrowed IAC was encountered in the adolescent age category and females, especially those with rapid growth. The diagnosis requires a careful analysis of the shape and diameters of the IAC. Radiologic measurements in the axial plane do not seem to be sufficient to confirm the diagnosis, and, therefore, an analysis of diameters in the coronal plane is required. Treatment with sodium-channel blockers drugs showed promising results not only by relieving vertigo but also by normalizing the electrophysiological findings. In conclusion, a narrowed IAC can be considered in patients suffering from VP.
The Influence of Age on Cerebral Tissue Oxygenation in Vasovagal Syncope and Orthostatic Hypotension
Authors: Kharraziha Isabella , Torabi Parisa , Johansson Madeleine , Sutton Richard , Fedorowski Artur , Hamrefors Viktor
Published: July 2022

Age-related physiological impairment increases susceptibility to syncope. We tested the hypotheses that cerebral oxygenation during orthostatic provocation, as well as the level at which syncope occurs, differs according to age. Non-invasive hemodynamic monitoring and cerebral oximetry were applied during a head-up tilt test in 139 patients with vasovagal syncope (mean (SD) 45, (17) years, 60%-female); 121 patients with orthostatic hypotension (61.4 (19.2) years, 49.6%-female); and 82 patients with a negative head-up tilt test (45 (18) years, 61%-female). Group differences in cerebral tissue oxygenation levels and systolic blood pressure were assessed in supine at 3 and 10 min of orthostatic provocation, 30 s before (i.e., presyncopal phase) and during syncope in age groups of <30, 30–60, and >60 years. During the head-up tilt test, cerebral tissue oxygenation at the presyncopal phase decreased with age, both in patients with vasovagal syncope (<30 years: 66.9 ± 6.2, 30–60: 64.5 ± 6.1, >60: 62.2 ± 5.8%; p = 0.009) and orthostatic hypotension (<30: 67.4 ± 4.4, 30–60: 61.6 ± 6.2, >60: 57.5 ± 3.9; p < 0.001). Mean systolic blood pressure at the presyncopal phase did not differ according to age. Cerebral oxygenation prior to syncope in older individuals with vasovagal syncope and orthostatic hypotension is lower compared with younger individuals independently of systolic blood pressure. This suggests that the level of cerebral oxygenation at which syncope is elected is lower in older individuals.
Novel Therapeutic Devices in Heart Failure
Authors: Guzik Mateusz , Urban Szymon , Iwanek Gracjan , Biegus Jan , Ponikowski Piotr , Zymliński Robert
Published: July 2022

Heart failure (HF) constitutes a significant clinical problem and is associated with a sizeable burden for the healthcare system. Numerous novel techniques, including device interventions, are investigated to improve clinical outcome. A review of the most notable currently studied devices targeting pathophysiological processes in HF was performed. Interventions regarding autonomic nervous system imbalance, i.e., baroreflex activation therapy; vagus, splanchnic and cardiopulmonary nerves modulation; respiratory disturbances, i.e., phrenic nerve stimulation and synchronized diaphragmatic therapy; decongestion management, i.e., the Reprieve system, transcatheter renal venous decongestion system, Doraya, preCardia, WhiteSwell and Aquapass, are presented. Each segment is divided into subsections: potential pathophysiological target, existing evidence and weaknesses or unexplained issues. Novel therapeutic devices represent great potential in HF therapy management; however, further evidence is necessary to fully evaluate their utility.
Ectopic Prostate Tissue in the Uterine Cervix of a Female with Non-Classic Congenital Adrenal Hyperplasia—A Case Report
Authors: Tschaidse Lea , Auer Matthias K. , Dubinski Ilja , Lottspeich Christian , Nowotny Hanna , Schmidt Heinrich , Gut Nadezda , Reisch Nicole
Published: July 2022

Introduction: The occurrence of ectopic prostate tissue in the female genital tract is rare and has only been described sporadically. The origin of these lesions is unclear, but their appearance seems to be associated with various forms of androgen excess, including androgen therapy for transgender treatment or disorders of sex development, such as classic congenital adrenal hyperplasia (CAH). This is the first described case of ectopic prostate tissue in the cervix uteri of a 46,XX patient with a confirmed diagnosis of non-classic CAH due to 21-OHD and a history of mild adrenal androgen excess. Case presentation: We describe a 34-year-old patient with a genetic diagnosis of non-classic CAH due to 21-hydroxylase deficiency (21-OHD) with a female karyo- and phenotype and a history of mild adrenal androgen excess. Due to dysplasia in the cervical smear, conization had to be performed, revealing ectopic prostate tissue in the cervix uteri of the patient. Conclusions: An association between androgen excess and the occurrence of prostate tissue is likely and should therefore be considered as a differential diagnosis for atypical tissue in the female genital tract.
3D Visualization System in Descemet Membrane Endothelial Keratoplasty (DMEK): A Six-Month Comparison with Conventional Microscope
Authors: Morelli Alberto , Ferrandina Rosangela , Favuzza Eleonora , Cennamo Michela , Mencucci Rita
Published: July 2022

Background: To compare the efficacy and safety of Descemet membrane endothelial keratoplasty (DMEK) surgery using the three-dimensional (3D) display system NGENUITY to DMEK surgery performed with the traditional microscope (TM) in patients affected by Fuchs Endothelial Corneal Disease (FECD). Methods: Retrospective comparative study of 40 pseudophakic eyes of 40 patients affected by FECD who underwent DMEK surgery. Twenty patients (3D group) were operated on using the 3D display system and 20 patients (TM group) were operated on using the traditional microscope. Best spectacle corrected visual acuity (BSCVA), central corneal thickness (CCT), endothelial cell density (ECD) and corneal densitometry (CD) values were documented before and at 1, 3 and 6 months after DMEK. Intra- and postoperative complications were recorded. Results: The baseline assessments did not differ between the two groups (p > 0.05). Global surgical time and time to perform descemetorhexis were significantly lower in the TM group (p = 0.04 and p = 0.02, respectively). BSCVA, CCT, ECD and CD values did not differ significantly in the two groups at all follow-ups (p > 0.05). Complication rate was similar between the two groups. Conclusion: Three-dimensional display systems can be securely employed in DMEK surgery considering the satisfactory clinical outcomes, including Scheimpflug CD. Nevertheless, the slightly longer surgical time of the 3D DMEKs may lead to surgeons’ hesitancy. The main advantages of the heads-up approach may be the improved ergonomic comfort during surgery and the utility of assistants in surgical training.
Genetic Background and Clinical Features in Arrhythmogenic Left Ventricular Cardiomyopathy: A Systematic Review
Authors: Bariani Riccardo , Rigato Ilaria , Cason Marco , Bueno Marinas Maria , Celeghin Rudy , Pilichou Kalliopi , Bauce Barbara
Published: July 2022

In recent years a phenotypic variant of Arrhythmogenic cardiomyopathy has been described, characterized by predominant left ventricular (LV) involvement with no or minor right ventricular abnormalities, referred to as Arrhythmogenic left ventricular cardiomyopathy (ALVC). Different disease-genes have been identified in this form, such as Desmoplakin (DSP), Filamin C (FLNC), Phospholamban (PLN) and Desmin (DES). The main purpose of this critical systematic review was to assess the level of knowledge on genetic background and clinical features of ALVC. A search (updated to April 2022) was run in the PubMed, Scopus, and Web of Science electronic databases. The search terms used were “arrhythmogenic left ventricular cardiomyopathy” OR “arrhythmogenic cardiomyopathy” and “gene” OR “arrhythmogenic dysplasia” and “gene”. The most represented disease-gene turned out to be DSP, accounting for half of published cases, followed by FLNC. Overall, ECG abnormalities were reported in 58% of patients. Major ventricular arrhythmias were recorded in 26% of cases; an ICD was implanted in 29% of patients. A total of 6% of patients showed heart failure symptoms, and 15% had myocarditis-like episodes. DSP is confirmed to be the most represented disease-gene in ALVC patients. An analysis of reported clinical features of ALVC patients show an important degree of electrical instability, which frequently required an ICD implant. Moreover, myocarditis-like episodes are common.
Post-Bariatric Plastic Surgery: Abdominoplasty, the State of the Art in Body Contouring
Authors: Sadeghi Payam , Duarte-Bateman Daniela , Ma Wanyan , Khalaf Ryan , Fodor R’ay , Pieretti Gorizio , Ciccarelli Feliciano , Harandi Hamed , Cuomo Roberto
Published: July 2022

Due to the increased prevalence of obesity in the last decades, bariatric surgery has been on the rise in recent years. Bariatric surgery is a compelling option for weight loss in obese patients with severe obesity-related comorbidities or for whom lifestyle modifications have proven ineffective. Redundant skin following significant weight loss is a common occurrence affecting up to 96% of patients who undergo bariatric surgery, negatively impacting physical and psychosocial health and detracting from activities of daily living. Statistics of the American Society of Plastic Surgeons show that 46,577 body contouring procedures were performed after massive weight loss in the USA in a 2020 report. Abdominoplasty, a well-established cosmetic surgery procedure for improving body contour, is performed by removing excess skin and fat from the abdominal wall and thereby restoring musculofascial integrity and skin elasticity, resulting in a more ideal body shape and increasing quality of life. Although abdominoplasty is a safe procedure, it has been associated with a higher complication rate compared with other body-contouring procedures. Technologic advances over the past decade have been developed as non-invasive alternatives or adjunctive tools to surgery to enhance cosmetic results and minimize complications. New energy-based technologies may supplant invasive surgery for mild to moderate skin laxity and/or diminish the extent of surgery and resulting scars. Plastic surgeons play a significant role in improving the quality of life of patients who suffer from obesity and underwent bariatric surgery. We are deeply convinced, however, that the advancement of knowledge and research in this field will determine the introduction of new technologies and custom-made techniques. This advancement will reduce the complication rate with a rapid reintegration of the patient into the world of work and resumption of daily activities.
Persistence of Depression and Anxiety despite Short-Term Disease Activity Improvement in Patients with Systemic Lupus Erythematosus: A Single-Centre, Prospective Study
Authors: Nikoloudaki Myrto , Repa Argyro , Pitsigavdaki Sofia , Molla Ismail Sali Ainour , Sidiropoulos Prodromos , Lionis Christos , Bertsias George
Published: July 2022

Mental disorders such as anxiety and depression are prevalent in systemic lupus erythematosus (SLE) patients, yet their association with the underlying disease activity remains uncertain and has been mostly evaluated at a cross-sectional level. To examine longitudinal trends in anxiety, depression, and lupus activity, a prospective observational study was performed on 40 adult SLE outpatients with active disease (SLE Disease Activity Index [SLEDAI]-2K ≥ 3 [excluding serology]) who received standard-of-care. Anxiety and depression were determined at baseline and 6 months by the Hospital Anxiety and Depression Scale. Treatment adherence was assessed with the Morisky Medication Adherence Scale-4. Increased anxiety (median [interquartile range] HADS-A: 11.0 [7.8]) and depression (HADS-D: 8.0 [4.8]) were found at inclusion, which remained stable and non-improving during follow-up (difference: 0.0 [4.8] and −0.5 [4.0], respectively) despite reduced SLEDAI-2K by 2.0 (4.0) (p < 0.001). Among possible baseline predictors, paid employment—but not disease activity—correlated with reduced HADS-A and HADS-D with corresponding standardized beta-coefficients of −0.35 (p = 0.017) and −0.27 (p = 0.093). Higher anxiety and depression correlated with lower treatment adherence (p = 0.041 and p = 0.088, respectively). These results indicate a high-mental disease burden in active SLE that persists despite disease control and emphasize the need to consider socioeconomic factors as part of comprehensive patient assessment.
Guided Treatment of Helicobacter pylori Infections with Non-Invasive PCR Tests—The Glory Days of Primary Care?
Authors: Pichon Maxime , Freche Bernard , Burucoa Christophe
Published: July 2022

In the original article [...]
MLP-PSO Hybrid Algorithm for Heart Disease Prediction
Authors: Al Bataineh Ali , Manacek Sarah
Published: July 2022

Background: Machine Learning (ML) is becoming increasingly popular in healthcare, particularly for improving the timing and accuracy of diagnosis. ML can provide disease prediction by analyzing vast amounts of healthcare data, thereby, empowering patients and healthcare providers with information to make informed decisions about disease prevention. Due to the rising cost of treatment, one of the most important topics in clinical data analysis is the prediction and prevention of cardiovascular disease. It is difficult to manually calculate the chances of developing heart disease due to a myriad of contributing factors. Objective: The aim of this paper is to develop and compare various intelligent systems built with ML algorithms for predicting whether a person is likely to develop heart disease using the publicly available Cleveland Heart Disease dataset. This paper describes an alternative multilayer perceptron (MLP) training technique that utilizes a particle swarm optimization (PSO) algorithm for heart disease detection. Methods: The proposed MLP-PSO hybrid algorithm and ten different ML algorithms are used in this study to predict heart disease. Various classification metrics are used to evaluate the performance of the algorithms. Results: The proposed MLP-PSO outperforms all other algorithms, obtaining an accuracy of 84.61%. Conclusions: According to our findings, the current MLP-PSO classifier enables practitioners to diagnose heart disease earlier, more accurately, and more effectively.
Early-Stage Detection of Ovarian Cancer Based on Clinical Data Using Machine Learning Approaches
Authors: Ahamad Md. Martuza , Aktar Sakifa , Uddin Md. Jamal , Rahman Tasnia , Alyami Salem A. , Al-Ashhab Samer , Akhdar Hanan Fawaz , Azad AKM , Moni Mohammad Ali
Published: July 2022

One of the common types of cancer for women is ovarian cancer. Still, at present, there are no drug therapies that can properly cure this deadly disease. However, early-stage detection could boost the life expectancy of the patients. The main aim of this work is to apply machine learning models along with statistical methods to the clinical data obtained from 349 patient individuals to conduct predictive analytics for early diagnosis. In statistical analysis, Student’s t-test as well as log fold changes of two groups are used to find the significant blood biomarkers. Furthermore, a set of machine learning models including Random Forest (RF), Support Vector Machine (SVM), Decision Tree (DT), Extreme Gradient Boosting Machine (XGBoost), Logistic Regression (LR), Gradient Boosting Machine (GBM) and Light Gradient Boosting Machine (LGBM) are used to build classification models to stratify benign-vs.-malignant ovarian cancer patients. Both of the analysis techniques recognized that the serumsamples carbohydrate antigen 125, carbohydrate antigen 19-9, carcinoembryonic antigen and human epididymis protein 4 are the top-most significant biomarkers as well as neutrophil ratio, thrombocytocrit, hematocrit blood samples, alanine aminotransferase, calcium, indirect bilirubin, uric acid, natriumas as general chemistry tests. Moreover, the results from predictive analysis suggest that the machine learning models can classify malignant patients from benign patients with accuracy as good as 91%. Since generally, early-stage detection is not available, machine learning detection could play a significant role in cancer diagnosis.
Making the Case for Parks: Construction of an Ecological Network of Urban Parks Based on Birds
Authors: Yang Yang , Zhou Yanru , Feng Zhe , Wu Kening
Published: July 2022

Urban expansion occurs in horizontal and vertical directions, but the construction process of a traditional planar ecological network (EN) ignores the ecological protection of the vertical space. Birds, as representative species in urbanized areas, are important for expanding the vertical analysis dimension of ENs. In this study, urban parks with good habitat quality were extracted as ecological sources from the perspective of birds. Then, 2D and 3D ecological resistance surfaces were constructed on the basis of the perspective of influencing bird migration, and planar and 3D ecological corridors were extracted and compared for analysis. Finally, accessibility analysis was performed to identify the parks in the study area that need priority protection. Results show that building height is an important factor affecting bird migration, and the introduction of 3D resistance surfaces into EN construction is important for adapting to the trend of vertical urban expansion. The combination of accessibility and EN analyses can help identify ecological spaces having the dual role of “species conservation” and “human well-being enhancement.” This study can provide a reference for refining the service species of ENs, exploring the vertical dimension of ENs, and improving the health of urban ecosystems and the rationality of urban planning.