bluuebunny/crossref_metadata_2025 huggingface dataset:
Risiko Herbisida Paraquat Diklorida terhadap Ginjal Tikus Putih Spraque Dawley
Authors: Kasban Muhartono Sudarmo , Windarti Indri - , Liantari Diah Septia , - Susianti -
Published: December 2022

Herbisida merupakan salah satu bahan kimia yang sering digunakan oleh para petani untuk mematikan tanaman pengganggu. Disisi lain penggunaan herbisida sering tidak sesuai prosedur sehingga dapat menimbulkan efek samping terhadap manusia. Paparan herbisida paraquat diklorida berpengaruh ke organ-organ tubuh manusia. Pada organ ginjal dapat merusak glomerulus dan tubulus ginjal. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian herbisida golongan paraquat diklorida per-oral terhadap gambaran histopatologi ginjal tikus putih (Rattus norvegicus) jantan galur Sprague Dawley. Penelitian ini merupakan penelitian eksperimental yang dilakukan di Laboratorium Patologi Anatomi FK Unila pada bulan Oktober sampai November 2014 dengan menggunakan 25 ekor tikus putih (Rattus norvegicus) jantan galur Sprague Dawley berumur 8âˆ’10 minggu. Tikus dibagi dalam 5 kelompok secara acak dan diberi perlakuan selama 2 hari. K1 diberi aquadest, K2, K3, K4, K5 diberi herbisida paraquat diklorida 25mg/kgBB/hari, 50mg/kgBB/hari, 100mg/kgBB/hari dan 200mg/kgBB/hari. Hasil penelitian menunjukan bahwa rerata skor kerusakan ginjal pada K1: 0, K2: 1,8, K3: 2,0, K4:3,6, K5; 4,4. Data yang diperoleh diuji dengan Uji Kruskal Wallis didapatkan perbedaan bermakna (p=0,001). Simpulan, pemberian herbisida golongan paraquat diklorida perâˆ’oral dapat merusak ginjal tikus putih (Rattus norvegicus) jantan galur Sprague Dawley.
Segmentasi Geografi dan Perilaku Berpengaruh terhadap Keputusan Memilih Layanan Rawat Inap di Rumah Sakit
Authors: Tae Vidria Handayani , Hariyanti Tita , Rasyid Harun Al
Published: December 2022

Rendahnya pemanfaatan tempat tidur di rumah sakit menandakan rumah sakit perlu melakukan strategi pemasaran sosial. Segmentasi pengguna layanan kesehatan merupakan salah satu strategi untuk mendefinisikan kebutuhan pengguna. Penelitian ini bertujuan untuk mengetahui hubungan segmentasi pengguna dengan keputusan memilih layanan rawat inap di rumah sakit. Responden dalam penelitian yang berdesain cross sectional ini adalah penduduk dari 7 kecamatan yang berusia â‰¥18 tahun sejumlah 279 orang dan pernah memanfaatkan layanan rawat inap di rumah sakit. Penelitian ini menggunakan lembar kuesioner dengan variabel segmentasi geografi, segmentasi demografi, segmentasi psikografi dan segmentasi perilaku sebagai variabel independen. Analisis data menggunakan regresi linear berganda. Hasil penelitian menemukan bahwa seluruh variabel independen secara bersama-sama berhubungan signifikan (Î²=10,960 dan p=0,000) dengan keputusan memilih layanan rawat inap di rumah sakit. Hasil pengujian secara parsial menunjukkan bahwa hanya segmentasi geografi (Î²=-0,131 dan p=0,016) dan perilaku (Î²=0,385 dan p=0,000) berhubungan dengan keputusan memilih layanan rawat inap di rumah sakit. Kata Kunci: Layanan rawat inap, keputusan membeli, segmentasi pasar
Derajat Depresi Pasien Hepatitis C Kronis yang Mendapat Terapi PegIFN-Î±
Authors: Indriyaningrum Nurria Betty , Brahmantyo Herwindo Pudjo , Mustika Syifa
Published: December 2022

Disamping efek dari infeksi hepatitis C, pengobatan hepatitis C dengan menggunakan pegylated interferon alfa dikatakan memiliki efek samping berupa depresi. Untuk mengevaluasi gejala depresi pada pasien hepatitis C yang mendapatkan terapi pegylated interferon alfa di divisi Gastroentero-hepatologi RSUD Dr. Saiful Anwar Malang. Penilaian depresi dilakukan 1 kali, dengan menggunakan kuisioner Patient Health Questionnaire 9 (PHQ-9). Penelitian ini dilakukan antara tahun 2014-2015. Seluruh pasien hepatitis C yang mendapatkan terapi dengan pegylated interferon alfa, diberikan formulir kuisioner dari Patient Health Questionnaire (PHQ-9) untuk dievaluasi kondisi depresi yang terjadi. Dari keseluruhan pasien berjumlah 24 pasien, didapatkan hasil berupa depresi minimal sebanyak 9 pasien (37,5%), depresi ringan sebanyak 12 pasien (50%), depresi sedang sebanyak 2 pasien (8,3%) dan depresi sedang-berat sebanyak 1 pasien (4,2%). Rerata usia pasien adalah 53,55Â±12,13 (dalam tahun), dengan rentang usia 30-73 tahun. Jumlah pasien pria sama dengan jumlah pasien wanita (masing-masing 12 orang). Rerata lama terapi adalah 17,78Â±11,88 (dalam minggu). Genotipe terbanyak adalah genotipe 1 (16 pasien, 66,67%). Manifestasi depresi yang terbanyak adalah kelelahan yang terus menerus dan penurunan nafsu makan. Penelitian membuktikan adanya gangguan depresi pada pasien-pasien hepatitis C yang mendapat terapi pegylated interferon alfa (pegIFNÎ±). Penilaian kondisi mental sebelum memulai terapi dan setelah selesai terapi, perlu dilakukan secara rutin untuk menilai adanya efek samping yang perlu ditangani secara lebih lanjut.Kata Kunci: Derajat depresi, hepatitis C kronis, pegIFNÎ±
Risiko Kardiovaskular Berdasarkan Faktor Jaminan Kesehatan pada Masyarakat Pedesaan di Kabupaten Sleman Yogyakarta
Authors: Suhadi Rita - , Linawati Yunita , Virginia Dita Maria , Setiawan Christianus Heru
Published: December 2022

Penyakit kardiovaskular merupakan risiko kesehatan terbesar di Indonesia. Penelitian survei cluster random sampling tahun 2015, program jaminan kesehatan berhasil meningkatkan kesadaran dan terapi pada subjek dengan tekanan darah â‰¥140/90mmHg di Kabupaten Sleman Yogyakarta. Penelitian ini bertujuan untuk mengevaluasi risiko kardiovaskular terkait program jaminan kesehatan. Penelitian ini merupakan survei potong lintang analitik dan subanalisis pada subjek yang dapat dihitung risiko kardiovaskular 10 tahun ke depan menggunakan skor Framingham. Penelitian dilakukan pada subjek berumur 30-74 tahun dan menandatangani informed-consent. Subjek dikelompokkan berdasarkan dengan atau tanpa jaminan kesehatan. Data rerata umur, body mass index (BMI), tekanan darah, dan skor Framingham dianalisis dengan uji-t (p<0,05), sedangkan tingkatan risiko kardiovaskular 10 tahun ke depan dianalisis menggunakan statistik chi-square.Â  Dari penelitian ini ditemukan sebanyak 64,6% dari 429 subjek memiliki jaminan kesehatan dalam beberapa sistem jaminan. Parameter observasi kelompok dengan dan tanpa jaminan kesehatan tidak berbeda bermakna (p>0,05) untuk variabel umur, gender, merokok, pendidikan, tekanan darah, hiperglikemia, dan BMI. Subjek dengan dan tanpa jaminan kesehatan berturut-turut memiliki tekanan darah sistolik 156,5 (22,2) mmHg berbanding 156,4 (20,0) mmHg dan skor Framingham 18,4 (9,3)% berbanding 19,2 (9,3)% (p>0,05) yang termasuk kategori risiko kardiovaskular sedang. Pada subkelompok subjek dengan tekanan darah â‰¥140/90 mmHg (n=347, 80,9%) subjek dengan jaminan kesehatan (n=277, 53,2%) dan tanpa jaminan kesehatan memiliki skor Framingham yang tidak berbeda bermakna, namun berbeda kategori risikonya yaitu 19,8 (8,9)% kategori risiko sedang berbanding 21,1 (8,3)% kategori risiko tinggi. Kesimpulan, jaminan kesehatan belum terbukti menurunkan secara bermakna risiko kardiovaskular subjek di pedesaan di Sleman-Yogyakarta.
Effect of Simvastatin Administration on ALP (Alkaline Phosphatase) Level in Wistar Rat's Femur Fracture
Authors: Susilo Hery , Mustamsir Edi , Rai Wanda Gusta
Published: December 2022

Metabolism of the bone healing process can be monitored by Bone formation marker, such as alkaline phosphate (ALP). Simvastatin is known to increase bone marker formation in the repair phase, but its effects on the ALP level have not been known yet. This study aimed to determine the effect of oral simvastatin administration on the expression of ALP level in femur fracture healing in a rat model of femur fracture. The research method was experimental post-test only using 18 Rattus norvegicus rats which were divided into 3 groups, namely the control group for femur fracture (Control), femoral fracture group and giving simvastatin 0.36 mg/day for 2 weeks (Treatment I), and femur fracture group and administration of simvastatin 0.36 mg/day for 4 weeks (Treatment II). ALP levels were measured at 0, 2, and 4 weeks. The results showed an increase in ALP levels in the simvastatin treatment group compared to the control group (p<0.05). It can be concluded that the administration of simvastatin increased ALP levels in rat femoral fractures.
Antioxidant Properties of TeNan Herbal Tea Formulation “Telang (Clitoria ternatea) and Pineapple (Ananas comosus)”
Authors: Widowati Wahyu , Wargasetia Teresa Liliana , Marthania Meganita , Hanifa Tazkia Salma , Zakaria Teddy Marcus , Gunadi Michael Sebastian , Halim Natanael , Santiadi Sheryl
Published: December 2022

Herbal teas was are widely consumed by people around the world have high antioxidant activities. The flavor and color combination of specific teas enriches the aroma and appearance of the tea, producing a tea with fresh color and tastier flavor. This study determines the antioxidant activity of telang flower tea (Clitoria ternatea), pineapple tea (Ananas comosus), and the formula of the combination of telang flower tea and pineapple tea called TeNan. The antioxidant activities of herbal teas were measured by 2,2 Diphenyl-1-picrylhydrazyl (DPPH), Hydrogen Peroxide (H2O2), 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), Ferric Reducing Antioxidant Power (FRAP) assay. The total phenol measurement used Gallic Acid Equivalent (GAE), while the flavonoid content measurement used Quercetin Equivalent (QE). The DPPH scavenging activities of telang flower tea, pineapple tea, and TeNan tea (IC50: 17.07%, 11.81%, and 22.22%), H2O2 scavenging activities (IC50: 26.62%, 41.81%, and 96.22%), ABTS-reducing activities (IC50: 2.51%, 3.39%, and 1.02%), and FRAP activities (IC50: 5.56%, 18.67%, and 7.48%). The total phenolic and flavonoid contents of TeNan tea were lower (9.44 μg GAE/100%; 3.46 μg QAE/100% sample concentration) than those of telang flower tea (16.20 μg GAE/100%; 4.88 μg QAE/100% sample concentration) but higher than those of pineapple tea (0.82 μg GAE/100%; 0.17 μg QAE/100% sample concentration). TeNan tea has the higher in ABTS and FRAP activities but lower in H2O2 and DPPH scavenging activities compared to telang flower tea and pineapple tea. In summary, telang tea has stronger antioxidant activity compared to pineapple and TeNan tea in FRAP and H2O2 assays.
Comparative Assessment of the Safety between Pazopanib and Sunitinib for Metastatic Renal Cell Carcinoma
Authors: Rahman Eka Yudha , Nur Choirin , Yulizar Deddy Rasyidan
Published: December 2022

Renal cell carcinoma (RCC) is the most common kidney lesion with approximately 90% of all kidney malignancies and 30% of people with RCC have developed metastasis at the time of diagnosis. Based on European Association of Urology (EAU) guideline, therapy for metastatic RCC (mRCC) patient who cannot tolerate immune checkpoint inhibitor is pazopanib or sunitinib. However, these drugs cause several uncomfortable side effects for the patient. Therefore, this meta-analysis was made, based on the available evidence base, to compare the safety of pazopanib and sunitinib as the treatment of mRCC. Systematic reviews were made in accordance with the PRISMA guideline requirements, a literature review was conducted in January 2022 used PubMed, ScienceDirect, Cochrane Library, publishing year of at least 10 years with an adult population. And the data is analyzed using RevMan V.5.4. In total 1.665 participants, there were 431 patients taking pazopanib and 1.234 patients taking sunitinib from 8 studies. The result shows that sunitinib has more frequent result of side effects than pazopanib in several occasion like hand-foot syndrome, nausea/vomiting, skin rash, stomatitis & mucosal inflammation, leucopenia and thrombocytopenia. Meanwhile, there are no significant differences between pazopanib and sunitinib in causing other side effect such as fatigue, diarrhea, hypertension, anemia, and increased liver enzymes. The conclusion is that pazopanib is better and has less frequent side effects than sunitinib.
COVID-19 Through the Eyes of a Physiatrist: Back Pain Can Be a Symptom and May Predict Pneumonia in COVID-19
Authors: Uz Cuma
Published: December 2022

The study aimed to determine whether back pain is a clinical manifestation in patients with COVID-19 and whether several demographic and disease characteristics could be an effective indicator of back pain.

Materials and Methods. A total of 99 patients with COVID-19 were recruited from the Department of Infectious Diseases of the Kirikkale High Specialized Hospital in Turkey and divided into two groups depending on the presence (n=50) or absence of back pain (n=49). The primary outcomes included were demographic and disease characteristics, the Nord-Trøndelag Health Study Physical Activity Level for Work (HUNT), and the 6-minute walking test.

Results. The most common symptom was fatigue (n=63, 63.6%), followed by back pain (n=50, 50.5%). In the back pain group, the number of patients with sedentary lifestyle, oxygen requirement, pneumonia, and typical pneumonia pattern were significantly higher (p=0.009, p=0.026, p=0.001, p=0.001, respectively), while aerobic capacity was lower (p=0.001). In a logistic regression analysis, back pain was found to be associated with pneumonia presence.

Conclusions. Back pain may be associated with the presence of COVID-19 pneumonia and should be evaluated as its early warning symptom.
Microbiological Assessment of Glycyrrhizic Acid Effectiveness in Bacterial Vaginosis – A Comparative Study
Authors: Ostafiichuk Svitlana , Polishchuk Ivan , Perkhulyn Oksana , Kusa Olena , Henyk Nataliya , Makarchuk Oksana , Kurovets Lesya , Kutsyk Roman
Published: December 2022

Background. Bacterial vaginosis (BV) is one of the most common female diseases, which is currently characterized by an increasing rate of clinical sign reccurence, the appearance of asymptomatic carriers, and atypical forms.

This study was aimed to evaluate the effectiveness of glycyrrhizic acid administration in the prevention of BV recurrence.

Materials and Methods. The study involved 88 women after BV treatment (metronidazole per os for seven days). Participants were randomly divided into two groups: the main group included 46 patients who were administered 0.1% glycyrrhizic acid intravaginally for three months after the main treatment; the control group comprised 42 women who received no anti-recurrence BV course. The effectiveness was assessed three and six months after the beginning of treatment and included gynecological examination and laboratory assessments (pH, amine test, microbiological investigation).

Results. After recommended BV treatment without anti-recurrence course, the recurrence of laboratory criteria for BV increased three months after the treatment, including the increase in vaginal pH to > 4.5 in all subjects, positive amine test in 35.7% of patients, the presence of Gardnerella vaginalis at a concentration of 104-105 CFU/ml in 31.0% of women, reduction in the frequency of Lactobacillus detection with worsening of the condition and the onset of clinical manifestations of the disease six months later. In the main group, after glycyrrhizic acid administration, laboratory criteria of BV recovery three months after the treatment, and clinical and laboratory markers of BV recovery six months after the treatment were lower as compared to the control group.

Conclusions. The anti-recurrence course of BV (vaginal administration of 0.1% glycyrrhizic acid) demonstrated a decrease in the frequency of complaints, clinical and laboratory markers, stabilization of the species composition of Lactobacillus, and a decrease in facultative anaerobe concentration in the vaginal microbiome as compared to group without anti-recurrence treatment.
Neurogenic Myositis Ossificans of the Hip in a Patient with Axonal Polyneuropathy
Authors: Tlaite Oubaddi , Kaoutar Imrani , Soufiane Rostoum , Nabil Moatassim Billah , Ittimad Nassar
Published: December 2022

Background. Neurogenic myositis ossificans is a rare entity defined by the development of soft tissue ossifications in patients with paraplegia or tetraplegia following neurological pathologies, often after cranial or spinal cord trauma. The diagnosis is based on imaging, in particular CT scan, which often reveals the presence of intramuscular ossifications of periarticular location. Treatment is based on analgesics, physiotherapy, and surgery as a last resort.

Case Report. We present a case of neurogenic myositis ossificans in a 26-year-old patient followed for axonal polyneuropathy secondary to vitamin deficiency.

Conclusions. Neurogenic myositis ossificans is a rare entity but is easily diagnosed, given the context of severe neurological disorders and the characteristic appearance on CT scan. In doubtful and atypical cases, a biopsy with histological study is recommended.
PENGEMBANGAN LEMBAR KEGIATAN PESERTA DIDIK BERBASIS SAINTIFIK PADA MATA PELAJARAN AKUNTANSI PERBANKAN SYARIAH
Authors: Berliana Sovia Riza , Hakim Luqman
Published: December 2022

Penelitian ini bertujuan untuk menghasilkan lembar kegiatan peserta didik atau LKPD berbasis saintifik mata pelajaran akuntansi perbankan syariah. Penelitian ini berfungsi mengetahui kelayakan LKPD yang dinilai oleh para ahli juga mengetahui respon dari peserta didik. Penelitian ini merupakan penelitian Research and Development (RD) memakai model 4D (Four D) oleh Thiagarajan yaitu define, design, develop, dan disseminate, tetapi dilakukan hanya dengan 3 tahapan hingga tahapan develop tanpa melaksanakan tahapan disseminate karena keterbatasan waktu dan biaya. Pada penelitian ini menggunakan dua angket yaitu angket terbuka yang diisi oleh ahli telaah pada lembar telaah dan angket tertutup untuk ahli validator untuk memvalidasi serta angket  respon peserta didik. Jenis data yang diperoleh pada pengembangan ini ialah data kuantitatif dan data kualitatif, kemudian dianalisa kembali secara deskriptif. Pengembangan ini mendapatkan hasil kelayakan dari segi muatan isi serta penyajian, segi bahasa, dan segi grafis dari hasil validasi para ahli validator dan mendapatkan hasil rata-rata kriteria sebesar 80,94% dikatakan layak. Hasil angket respon peserta didik yang diberikan kepada peserta didik kelas XII di SMK Negeri 2 Mojokerto mendapatkan hasil rata-rata sebesar 89,38% dikatakan sangat memahami sesuai kriteria. Hasil penilaian yang diperoleh ditarik kesimpulan LKPD yang dihasilkan dikatakan layak digunakan sebagai bahan ajar pendukung kegiatan pembelajaran. Kata Kunci: LKPD, Akuntansi Perbankan Syariah, Saintifik.
PENGARUH KEPEMIMPINAN GURU DAN KULTUR SEKOLAH TERHADAP IMPLEMENTASI NILAI-NILAI KARAKTER DALAM PEMBELAJARAN AKUNTANSI
Authors: Siswanto Siswanto
Published: December 2022

Tujuan penelitian ini adalah untuk mengetahui : (1) Kepemimpinan Guru Akuntansi dalam Pembelajaran Akuntansi ; (2) Kultur Sekolah dalam mengimplementasikan nilai-nilai karakter dalam Pembelajaran Akuntansi;(3) Pengaruh Kepemimpinan Guru terhadap implementasi nilai-nilai karakter dalam Pembelajaran Akuntansi;(4) pengaruh Kultur Sekolah terhadap implementasi nilai-nilai karakter dalam Pembelajaran Akuntansi. Penelitian ini menggunakan konstruksi survei. Populasi penelitian adalah Guru Akuntansi SMK Bisnis dan Manajemen di Daerah Istimewa Yogyakarta, dengan sampel penelitian 40 guru Akuntansi pada  20 Sekolah Menengah kejuruan yang terdiri dari 6 sekolah Negeri dan 14 sekolah Swata di 5 Kabupaten/Kota di DIY. Instrumen pengumpulan data menggunakan angket. Teknik analisis data menggunakan metode deskriptif kuantitatif dengan persentase dan analisis regresi sederhana.  Untuk mendeskripsikan Kepemimpinan  Guru dan Kultur Sekolah digunakan teknik analisis deskriptif kuantitatif, untuk mengetahui pengaruh kepemimpinan guru terhadap implementasi pendidikan karakter serta pengaruh kultur sekolah terhadap implementasi pendidikan karakter menggunakan analisis regresi sederhana. Hasil penelitian menunjukkan : (1) Kepemimpinan Guru Akuntansi dalam pembelajaran pada kategori Sangat Baik; (2) Kultur Sekolah untuk menginplementasikan nilai-nilai karakter pada kategori Sangat Baik; (3) Terdapat Pengaruh signifikan Kepemimpinan Guru Akuntansi terhadap Implementasi nilai-nilai Karakter dalam Pembelajaran Akuntansi; (4) Terdapat pengaruh signifikan Kultur Sekolah terhadap implemantasi nilai-nilai Karakter dalam  Pembelajaran Akuntansi. Kata Kunci : Kepemimpinan Guru, Kultur Sekolah, Nilai-nilai Karakter.
Defining a Role for Webinars in Surgical Training Beyond the COVID-19 Pandemic in the United Kingdom: Trainee Consensus Qualitative Study
Authors: Barlow Emma , Zahra Wajiha , Hornsby Jane , Wilkins Alex , Davies Benjamin M , Burke Joshua
Published: December 2022

Background

The COVID-19 pandemic posed several challenges for surgical training, including the suspension of many in-person teaching sessions in lieu of webinars. As restrictions have eased, both prepandemic and postpandemic training methods should be used.

Objective

This study investigates trainees’ experiences of webinars during the COVID-19 pandemic to develop recommendations for their effective integration into surgical training going forward.

Methods

This project was led by the Association of Surgeons in Training and used an iterative process with mixed qualitative methods to consolidate arguments for and against webinars, and the drivers and barriers to their effective delivery, into recommendations. This involved 3 phases: (1) a web-based survey, (2) focus group interviews, and (3) a consensus session using a nominal group technique.

Results

Trainees (N=281) from across specialties and grades confirmed that the COVID-19 pandemic led to an increase in webinars for surgical training. While there were concerns, particularly around the utility for practical training (80.9%), the majority agreed that webinars had a role in training following the COVID-19 pandemic (90.2%). The cited benefits included improved access or flexibility and potential standardization of training. The majority of limitations were technical. These perspectives were refined through focus group interviews (n=18) into 25 recommendations, 23 of which were ratified at a consensus meeting, which was held at the Association of Surgeons in Training 2021 conference.

Conclusions

Webinars have a role in surgical training following the COVID-19 pandemic. The 23 recommendations encompass indications and technical considerations but also discuss important knowledge gaps. They should serve as an initial framework for ensuring that webinars add value and continue to evolve as a tool for training.

Trial Registration

Chinese Clinical Trial Registry ChiCTR2200055325; http://www.chictr.org.cn/showprojen.aspx?proj=142802
Digital Intervention in Loneliness in Older Adults: Qualitative Analysis of User Studies
Authors: Stuart Avelie , Yan Ronnie Jieru , Harkin Lydia Jo , Katz Dmitri , Stevenson Clifford , Mehta Vikram , Giles Emilie , Talbot Catherine , Gooch Daniel , Bennasar Mohamed , Self Tara , Nuseibeh Bashar , Price Blaine
Published: December 2022

Background

Loneliness is a significant well-being issue that affects older adults. Existing, commonly used social connection platforms do not contain facilities to break the cognitive cycle of loneliness, and loneliness interventions implemented without due processes could have detrimental effects on well-being. There is also a lack of digital technology designed with older adults.

Objective

We aimed to iteratively design a user-centered smartphone app that can address loneliness in older adults. The aim of this study was to investigate the loneliness-related psychological processes that our conceptual smartphone app promotes. We also identified the emergent needs and concerns that older adults raised regarding the potential benefits and detriments of the app.

Methods

We used technology probes to elicit older adults’ reflections on the concept of using the app in 2 studies as follows: concept focus groups (n=33) and concept interviews (n=10). We then conducted a prototype trial with 1 week of use and follow-up interviews (n=12).

Results

Thematic analysis explored the experiences and emergent challenges of our app through the design process. This led to the development of 4 themes as follows occurring in all 3 qualitative data sets: reflection on a digital social map is reassuring; app features encourage socializing; the risk of compounding loneliness; and individuals feel more control with mutual, socially beneficial activities.

Conclusions

Smartphone apps have the potential to increase older adults’ awareness of the richness of their social connections, which may support loneliness reduction. Our qualitative approach to app design enabled the inclusion of older adults’ experiences in technology design. Thus, we conclude that the older adults in our study most desired functionalities that can support mutual activities and maintain or find new connections rather than enable them to share an emotional state. They were wary of the app replacing their preferred in-person social interaction. Participants also raised concerns about making the user aware of the lack of support in their social network and wanted specific means of addressing their needs. Further user-centered design work could identify how the app can support mutual activities and socializing.
An Unstructured Supplementary Service Data System to Verify HIV Self-Testing Among Nigerian Youths: Mixed Methods Analysis of Usability and Feasibility (Preprint)
Authors: Oladele David Ayoola , Iwelunmor Juliet , Gbajabiamila Titilola , Obiezu-Umeh Chisom , Okwuzu Jane Ogoamaka , Nwaozuru Ucheoma , Musa Adesola Zaidat , Tahlil Kadija , Idigbe Ifeoma , Ong Jason , Tang Weiming , Tucker Joseph , Ezechi Oliver
Published: December 2022

BACKGROUND

Mobile health (mHealth) interventions among adolescents and young adults (AYAs) are increasingly available in African low- and middle-income countries (LMICs). For example, the unstructured supplementary service data (USSD) could be used to verify HIV self-testing (HIVST) among AYAs with poor bandwidth.

OBJECTIVE

The aim of this study is to describe the creation of an USSD platform and determine its feasibility and usability to promote the verification of HIVST results among AYAs in Nigeria.

METHODS

We developed and evaluated a USSD platform to verify HIVST results using a user-centered approach. The USSD platform guided AYAs in performing HIVST, interpreting the result, and providing linkage to care after the test. Following the usability assessment, the USSD platform was piloted. We used a mixed methods study to assess the platform’s usability through a process of quantitative heuristic assessment, a qualitative think-aloud method, and an exit interview. Descriptive statistics of quantitative data and inductive thematic analysis of qualitative variables were organized.

RESULTS

A total of 19 AYAs participated in the usability test, with a median age of 19 (IQR 16-23) years. There were 11 females, 8 males, and 0 nonbinary individuals. All individuals were out-of-school AYAs. Seven of the 10 Nielsen usability heuristics assessed yielded positive results. The participants found the USSD platform easy to use, preferred the simplicity of the system, felt no need for a major improvement in the design of the platform, and were happy the system provided linkage to care following the interpretation of the HIVST results. The pilot field test of the platform enrolled 164 out-of-school AYAs, mostly young girls and women (101, 61.6%). The mean age was 17.5 (SD 3.18) years, and 92.1% (151/164) of the participants reported that they were heterosexual, while 7.9% (13/164) reported that they were gay. All the participants in the pilot study were able to conduct HIVST, interpret their results, and use the linkage to care feature of the USSD platform without any challenge. A total of 7.9% (13/164) of the AYAs had positive HIV results (reactive to the OraQuick kit).

CONCLUSIONS

This study demonstrated the usability and feasibility of using a USSD system as an alternative to mobile phone apps to verify HIVST results among Nigerian youth without smartphone access. Therefore, the use of a USSD platform has implications for the verification of HIVST in areas with low internet bandwidth. Further pragmatic trials are needed to scale up this approach.

CLINICALTRIAL
WeChat-Based HIV e-Report, a New Manner for HIV Serostatus Request and Disclosure and Their Associated Factors Among Men Who Have Sex With Men: Prospective Subgroup Analysis of Randomized Controlled Trails (Preprint)
Authors: Sun Hai-Tong , Fan Xiao-Ru , Gu Yu-Zhou , Lu Yong-Heng , Qiu Jia-Ling , Yang Qing-Ling , Li Jing-Hua , Gu Jing , Hao Chun
Published: December 2022

BACKGROUND

Requesting and disclosing HIV serostatus is associated with a reduction in HIV transmission among men who have sex with men (MSM). However, the reliability of common methods for HIV serostatus requests and disclosure is unsatisfactory. Validated approaches for requesting and disclosing HIV serostatus are necessary.

OBJECTIVE

The objective of this study was to investigate the use of the HIV e-report as authentic evidence of HIV serostatus among the MSM community in Guangzhou, China. Additionally, the study aimed to explore its correlates with HIV serostatus requesting and disclosure receiving behavior.

METHODS

This study is a subgroup analysis of a cluster randomized controlled trial (RCT) that enrolled 357 participants during the first year. Participants in this RCT were recruited from the WeChat-based HIV testing service miniprogram developed by Guangzhou Center for Disease Control and Prevention, China. Participants completed web-based questionnaires at baseline and at the month 3 follow-up, which covered sociodemographic characteristics, HIV-related information, HIV serostatus requests, HIV serostatus disclosure receiving, and HIV e-report usage. Univariate and multivariate logistic regressions were used for data analysis.

RESULTS

The WeChat-based HIV e-report was available in Guangzhou when the RCT project started. At the month 3 follow-up, 32.2% (115/357) of participants had their own HIV e-reports, and 37.8% (135/357) of them had received others’ HIV e-reports. For HIV serostatus requests, 13.1% (27/205) and 10.5% (16/153) of participants started to use HIV e-reports to ask the HIV serostatus of regular and casual male sex partners, respectively. Of the regular and casual male sex partners, 27.3% (42/154) and 16.5% (18/109), respectively, chose HIV e-reports to disclose HIV serostatus. Compared to MSM who did not have HIV e-reports, those who said, “I had had my own HIV e-report(s) but hadn’t sent to others” (multivariate odds ratio 2.71, 95% CI 1.19-6.86; P=.02) and “I had had my own HIV e-reports and had sent to others” (multivariate odds ratio 2.67, 95% CI 1.07-7.73; P=.048) were more likely to request HIV serostatus from their partners. Whereas no factor was associated with HIV serostatus disclosure received from partners.

CONCLUSIONS

The HIV e-report has been accepted by the MSM community in Guangzhou and could be applied as a new optional way for HIV serostatus request and disclosure. This innovative intervention could be effective in promoting infectious disease serostatus disclosure among the related high-risk population.

CLINICALTRIAL

ClinicalTrials.gov NCT03984136; https://clinicaltrials.gov/show/NCT03984136

INTERNATIONAL REGISTERED REPORT

RR2-10.1186/s12879-021-06484-y
Remote Patient Monitoring at Home in Patients With COVID-19: Narrative Review (Preprint)
Authors: Cornelis Justien , Christiaens Wendy , de Meester Christophe , Mistiaen Patriek
Published: December 2022

BACKGROUND

During the pandemic, health care providers implemented remote patient monitoring (RPM) for patients experiencing COVID-19. RPM is an interaction between health care professionals and patients who are in different locations, in which certain patient functioning parameters are assessed and followed up for a certain duration of time. The implementation of RPM in these patients aimed to reduce the strain on hospitals and primary care.

OBJECTIVE

With this literature review, we aim to describe the characteristics of RPM interventions, report on patients with COVID-19 receiving RPM, and provide an overview of outcome variables such as length of stay (LOS), hospital readmission, and mortality.

METHODS

A combination of different searches in several database types (traditional databases, trial registers, daily [Google] searches, and daily PubMed alerts) was run daily from March 2020 to December 2021. A search update for randomized controlled trials (RCTs) was performed in April 2022.

RESULTS

The initial search yielded more than 4448 articles (not including daily searches). After deduplication and assessment for eligibility, 241 articles were retained describing 164 telemonitoring studies from 160 centers. None of the 164 studies covering 248,431 patients reported on the presence of a randomized control group. Studies described a “prehosp” group (96 studies) with patients who had a suspected or confirmed COVID-19 diagnosis and who were not hospitalized but closely monitored at home or a “posthosp” group (32 studies) with patients who were monitored at home after hospitalization for COVID-19. Moreover, 34 studies described both groups, and in 2 studies, the description was unclear. In the prehosp and posthosp groups, there were large variations in the number of emergency department (ED) visits (0%-36% and 0%-16%, respectively) and no convincing evidence that RPM leads to less or more ED visits or hospital readmissions (0%-30% and 0%-22%, respectively). Mortality was generally low, and there was weak to no evidence that RPM is associated with lower mortality. Moreover, there was no evidence that RPM shortens previous LOS. A literature update identified 3 small-scale RCTs, which could not demonstrate statistically significant differences in these outcomes. Most papers claimed savings; however, the scientific base for these claims was doubtful. The overall patient experiences with RPM were positive, as patients felt more reassured, although many patients declined RPM for several reasons (eg, technological embarrassment, digital literacy).

CONCLUSIONS

Based on these results, there is no convincing evidence that RPM in COVID-19 patients avoids ED visits or hospital readmissions and shortens LOS or reduces mortality. On the other hand, there is no evidence that RPM has adverse outcomes. Further research should focus on developing, implementing, and evaluating an RPM framework.
Penulisan Naskah Film Pendek Komunitas Saba Eksploit SMAN I Bantul, DIY
Authors: Wibowo Ridha Mashudi , Ekasiswanto Rudi
Published: December 2022

The Official Selection World Cinema Amsterdam Award in 2019, given to the film "Tilik" opened the public's eyes to the fact that even a short film can convey a moral message as powerfully as a feature-length film. It does not matter that short films have more limitations than long ones. This phenomenon encourages short film script writing assistance as a community service activity. Saba Exploit (SE) SMAN 1 Bantul DIY was designated as the target for assistance because of its potential and impressive track record in making short films. Given the uneven transmission of knowledge and skills between generations, assistance is needed so that they have collective quality skills and skills, standardized guidelines for writing film scripts, and complete documentation so they can be developed across generations. Mentoring activities present speakers who present material presentations, best practices, and evaluations of films made by SE. The post-assistance evaluation stated that the curiosity of the SE community was accomplished. Hereafter, it was hoped that SE's hard skills, soft skills, and insights in creating short films would earn higher quality based on solid, focused, and expressive film script writing.

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Penghargaan Official Selection World Cinema Amsterdam pada 2019 yang diberikan kepada film “Tilik” membuka mata masyarakat bahwa film pendek pun bisa menyampaikan pesan moral yang sama kuatnya dengan film panjang. Hal tersebut dapat terjadi padahal film pendek memiliki lebih banyak keterbatasan. Fenomena tersebut mendorong pendampingan penulisan naskah film pendek sebagai kegiatan pengabdian kepada masyarakat. Saba Eksploit (SE) SMAN 1 Bantul DIY ditetapkan sebagai sasaran pendampingan karena potensi dan rekam jejak mengesankan dalam pembuatan film pendek. Mengingat pewarisan pengetahuan dan keterampilan yang tak mulus antargenerasi, diperlukan pendampingan agar mereka memiliki kemampuan dan keterampilan kolektif berkualitas, pedoman penulisan naskah film terstandarkan, serta dokumentasi lengkap agar dapat dikembangkan secara lintasgenerasi. Kegiatan pendampingan menghadirkan narasumber yang menyajikan presentasi materi, best practice, dan evaluasi atas film-film buatan SE. Evaluasi pascapendampingan menyatakan bahwa keingintahuan komunitas SE terpenuhi, sehingga diharapkan kemampuan keras, kemampuan lunak, dan wawasan SE terhadap pembuatan film pendek makin berkualitas didasarkan atas penulisan naskah film yang padat, terfokus, dan ekspresif.
Data Traffic Analysis on an Electric Current Monitoring System
Authors: Arrofiq Muhammad , Romadhon Mohammad Rizki
Published: December 2022

Change and Innovation continues as the times progress. Especially in the field of technology, one of which is the Internet of Things (IoT). With the existence of this technology, electronic devices can be connected to the internet. This will simplify the process of data transmission and device control. With this aim, the authors do research on the implementation of IoT technology on electronic devices, especially in the field of electricity. Electrical energy monitoring systems are used to detect the use of electrical energy used by the load. In this monitoring system, the measurement of the electric current using the current sensor. The measurement data made by the current sensor will be processed by the microcontroller. The research developed arduino-based monitoring systems and databases aimed at detecting and monitoring the use of electric current. In addition, it also performs analysis of data traffic from arduino devices and databases, to find out data delay, throughput or packet loss by using Wireshark.
Hubungan antara Kecanduan Game Internet dengan Keterampilan Sosial pada Remaja di Kota Yogyakarta
Authors: Laksono Devina Ngeksi Hari , Subekti Heru , Madyaningrum Ema
Published: December 2022

Background: Most Indonesians are internet users. Adolescents, who are active internet users and use internet for playing game too often, have the risk of experiencing online gaming addiction. Internet game addict may possess poor social skills.Objective: To find out the correlation between internet game addiction and social skills among adolescents in Yogyakarta.Method: This was an analytical study using cross sectional design. Participants of this study were 429 respondents from 8th grade of Junior High School students and 11th grade of Senior High School students in Yogyakarta. This research used “Indonesian Online Game Addiction” and “Social Skill Inventory” questionnaires. Data analysis used Somers’ D.Results: There were only few adolescents who were addicted to internet game (1,2%) and those who had mild internet game addiction (16,3%). Meanwhile, most of the adolescents had a moderate level of social skills (83,2%) and only 0,5% of adolescents with inferior social skills. The result of bivariate analysis of internet game addiction and social skills among adolescents in Yogyakarta showed a weak negative correlation (p<0,05, r= -0,124).Conclusion: Adolescents without internet game addiction will have high social skills.ABSTRAKLatar belakang: Sebagian besar penduduk Indonesia merupakan pengguna internet. Remaja yang terlalu sering bermain game internet memiliki risiko untuk mengalami kecanduan game online. Seseorang yang kecanduan bermain game internet dapat memiliki keterampilan sosial yang buruk.  Tujuan: Mengetahui hubungan antara kecanduan game internet dengan keterampilan sosial pada remaja di Kota Yogyakarta.Metode: Penelitian ini merupakan penelitian korelasi analitik dengan rancangan cross sectional. Responden penelitian ini adalah siswa kelas VIII SMP dan kelas XI SMA, yang berjumlah 429 responden. Pemilihan subjek penelitian menggunakan metode purposive sampling. Penelitian ini menggunakan kuesioner Indonesian Online Game Addiction dan Social Skill Inventory. Analisis data menggunakan Somers’ D.Hasil: Hanya sedikit dari responden yang mengalami kecanduan game internet (1,2%) dan mayoritas mengalami kecanduan game internet kategori ringan (16,3%). Sementara itu, sebagian besar remaja memiliki tingkat keterampilan sosial sedang (83,2%) dan hanya 0,5% remaja yang memiliki keterampilan sosial rendah. Hasil analisis bivariat terhadap kecanduan game internet dengan keterampilan sosial pada remaja di Kota Yogyakarta menunjukkan adanya hubungan (p<0,05, r=-0,124) yang lemah dengan arah negatif.Simpulan: Remaja yang tidak kecanduan game internet akan memiliki keterampilan sosial yang tinggi.
Prosodic Morphology of Verb and Adjective Syllables in Yi
Authors: JIMU Moyinai
Published: December 2022

Prosodic morphology is an important research object of prosodic typology, and also one of the important elements of prosody and morphology. This paper briefly discusses the prosodic form of the Yi language in terms of the number of syllables in verbs and adjectives. Pure verbs in Yi language usually appear in the form of single syllables. When restricted in grammatical activities, they are always flexibly used by adding the number of syllables, the most obvious one being nominalization. There are two types of adjectives in the Yi language, namely property adjective and state adjective. They can be mainly differentiated in terms of the syllable numbers of a word: the property adjectives are often monosyllabic, while the state adjectives are polysyllabic. The category of level is also expressed by adjusting the number of syllables. The more syllables, the greater the category of level change.
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 10
Authors: Simpson Alex , Ramagopalan Sreeram V
Published: December 2022

In this latest update we discuss the transportability of comparative effectiveness evidence across countries. We highlight results of a survey indicating that European HTA agencies are reluctant to accept real-world data from other countries, review recent benefit assessments indicating a potential softening of a requirement for the use of local real-world data in Germany, and outline a recent review presenting approaches that can correct for a lack of transportability.
Frequency of Meningococcal Meningitis Susceptibility Associated TLR4 +896 A/G (rs4986790) Allele in the Saudi Population
Authors: Alisaac Ali
Published: December 2022

Meningococcal meningitis (MM) is a severe central nervous system (CNS) infection that occurs primarily in children. MM can damage brain areas associated with hearing, learning, reasoning, focus, and memory. Genetic changes, including single nucleotide polymorphisms (SNPs), which compromise pathogen recognition increase the risk and severity of MM. There is little data on how the variation in the frequency of the rs4986790 polymorphism in the Toll-like receptor 4 (TLR4) gene may affect the population of Saudi Arabia. This study sought to determine the allelic frequency and distribution of the TLR4 rs4986790 A/G polymorphism in the Saudi population and compare the data to other global populations. Data from epidemiological studies conducted in various ethnic groups were extracted using PUBMED (Medline) and similar web databases. An estimated 5.88% of the Saudi population harbors the TLR4 rs4986790 G variant allele. This differed significantly from the frequencies in populations in China (p=0.0002), Japan (p=0.0001), Korea (p=0.0001), and Mexico (p=0.01). The TLR4 rs4986790 polymorphism variant allele has a unique pattern in the Saudi population, which may be the result of racial differences. These findings could assist in the risk assessment of people harboring the TLR4 +896 GG genotype susceptible to MM in the Saudi population.
Recent Advances in Methods Detecting the Dengue Virus
Authors: Alghamdi Mohamed K. , Bahieldin Ahmed , Edris Sherif
Published: December 2022

Dengue fever, caused by the Dengue virus (DENV), has emerged as a mild to lethal human infection. Globally, an estimated 400 million patients have been infected with DENV over the past 10 years, and this number is expected to increase in the coming years. The DENV, possessing a single positive- stranded RNA with five serotypes, is transmitted by mosquitos of the Flaviviridae family—particularly, the Flavivirus genus and Aedes species. The DENV genome encodes three structural and seven non- structural proteins. In the Kingdom of Saudi Arabia (KSA), serotype 2 of the dengue virus (DENV-2) emerged in 1994 and caused a major epidemic in Jeddah, KSA. Dengue outbreaks first appeared in Makkah in 2004, according to the characteristics studied in hospitalized patients. Major factors causing the wide and rapid distribution of the virus include increased urbanization, migration, global commerce, weather variation, inadequate mosquito control, the development of pesticide resistance in mosquitos, irregular use of insecticides, and shifting climatic circumstances. Detection methods currently used for DENV include the detection of viral antigens (Ag) (virus extraction and purification, immunofluorescence test, and NS1 detection assay), serological assays (plaque reduction neutralization titers (PRNT), IgM/IgG immunological assays), and RNA detection using RT-PCR. Low sensitivity, specificity, and accessibility of the detection protocols represent major challenges necessitating the advent of more amenable protocols. The Aedes mosquito is the primary vector for horizontal transmission of DENV. DENV-infected mosquitos infect people, and DENV passes from one human to another through this vector. Once acquired, the virus requires 5–7 days of incubation before the patient exhibits various symptoms of dengue fever; subsequently, uninfected mosquitoes that come in contact with infected patients feed on their blood and become infected. The DENV may also be spread through the mating of male and female Aedes mosquitoes. The reverse transcription loop-mediated isothermal application (RT-LAMP) has emerged as one of the most adaptable viral detection procedures. This method could prove to be an excellent pathogen detection tool because it is cheap, simple, sensitive, cost-effective, accessible, and fast. The method relies on the use of 4–6 primers to recognize eight different loci in the target sequence contained in the DENV clinical isolates with a 100% success rate and a sensitivity of about 93%. We strongly recommend the use of LAMP in detecting spots of virus spread, especially in urban regions where accessibility to detection methods is scarce.
Analysis of Steel Plate Shear Wall System Using Finite Element Analysis
Authors: Agrawal Payal , Patel Mahesh Ram
Published: December 2022

Abstract: A seismic wall is a lateral load resistance system used in high-rise buildings in earthquake-prone areas. The aim of the current research is to investigate the shear behavior of his SPSW using finite element method techniques. SPSW modeling and structural analysis are performed in software ANSYS 18. Critical areas of high stress and deformation are determined from the FEM analysis. The mode shapes and natural frequencies of SPSW are determined. Both structural and modal analyses, the highest deflection was observed at the top plate of the SPSW, indicating that this is the most fragile region under static and dynamic loading conditions