bluuebunny/crossref_metadata_2025 huggingface dataset:
Sparse Modeling Approach to the Arbitrage-Free Interpolation of Plain-Vanilla Option Prices and Implied Volatilities
Authors: Guterding Daniel
Published: April 2023

We present a method for the arbitrage-free interpolation of plain-vanilla option prices and implied volatilities, which is based on a system of integral equations that relates terminal density and option prices. Using a discretization of the terminal density, we write these integral equations as a system of linear equations. We show that the kernel matrix of this system is, in general, ill-conditioned, so that it cannot be solved for the discretized density using a naive approach. Instead, we construct a sparse model for the kernel matrix using singular value decomposition (SVD), which allows us not only to systematically improve the condition number of the kernel matrix, but also determines the computational effort and accuracy of our method. In order to allow for the treatment of realistic inputs that may contain arbitrage, we reformulate the system of linear equations as an optimization problem, in which the SVD-transformed density minimizes the error between the input prices and the arbitrage-free prices generated by our method. To further stabilize the method in the presence of noisy input prices or arbitrage, we apply an L1-regularization to the SVD-transformed density. Our approach, which is inspired by recent progress in theoretical physics, offers a flexible and efficient framework for the arbitrage-free interpolation of plain-vanilla option prices and implied volatilities, without the need to explicitly specify a stochastic process, expansion basis functions or any other kind of model. We demonstrate the capabilities of our method in a number of artificial and realistic test cases.
An Optimal Control Approach to the Minimum-Time Trajectory Planning of Robotic Manipulators
Authors: Massaro Matteo , Lovato Stefano , Bottin Matteo , Rosati Giulio
Published: April 2023

Trajectory planning is a classic problem in robotics, with different approaches and optimisation objectives documented in the literature. Most of the time, the path is assumed, i.e., pre-defined, and optimisation consists of finding the timing of motion under a number of constraints. The focus of this work is on the minimum-time manoeuvring of robotic manipulators. A nonlinear optimal control approach is proposed that does not require the provision of either a pre-defined path or a pre-defined control structure and allows the inclusion of dynamic constraints. The solution (path and timing of motion) is obtained by transforming the optimal control problem into a nonlinear programming problem. The proposed approach is applied to a two-link manipulator for illustration purposes. The optimisation is carried out both without and with obstacles. The minimum-distance and minimum-time solutions are compared, and some classic results are obtained, including the trapezoidal pattern of the joint velocity and the bang–bang structure of the control torques. The effects of limitations on the jerks of actuators and the rate of change in torque inputs are discussed. The application to a four-link manipulator is also included to show the ‘scalability’ of the approach, together with a comparison with a classic path-and-motion-planning method, to highlight the characteristics and performance of the proposed approach. Finally, the possibility of enforcing a number of via-points along the path is demonstrated. The proposed method allows the computation of the path and motion simultaneously with the computation time, which is 1–30 times the manoeuvre time, on a standard PC with the current implementation.
Arbuscular Mycorrhizal Fungi Enhance Growth and Increase Concentrations of Anthocyanin, Phenolic Compounds, and Antioxidant Activity of Black Rice (Oryza sativa L.)
Authors: Nacoon Sabaiporn , Seemakram Wasan , Ekprasert Jindarat , Theerakulpisut Piyada , Sanitchon Jirawat , Kuyper Thomas W. , Boonlue Sophon
Published: April 2023

Black rice (Oryza sativa L.) contains high concentrations of bioactive compounds that are associated with human-health benefits. Arbuscular mycorrhizal fungi (AMF) can increase plant performance and concentrations of these bioactive compounds. In a pot experiment, the effects of four different species of AMF (Claroideoglomus etunicatum; Rhizophagus variabilis; Rhizophagus nov. spec.; Acaulospora longula) were assessed on growth performance, grain yield, concentrations of phenolic compounds and anthocyanin, and antioxidant activity of two black-rice cultivars. The experiment was a completely randomized factorial design with two factors, viz. cultivar (Niew Dam Hmong and Maled Phai) and treatment (four different species of AMF and two non-inoculated treatments, without and with mineral fertilizer). Results showed that cultivar, treatment, and their interaction were almost always significant sources of variation for both plant performance parameters and concentrations of bioactive compounds. Maled Phai showed higher performance and higher concentrations of phenolics and anthocyanins but lower antioxidant activity than Niew Dam Hmong. The non-inoculated treatment without mineral fertilizer showed the lowest performance. The non-inoculated treatment with mineral fertilizer resulted in larger root and shoot biomass than the mycorrhizal treatments, but grain yield was higher in the mycorrhizal treatments. Inoculation with R. variabilis resulted in the highest concentration of phenolics and anthocyanins. We conclude that R. variabilis was the best inoculum for increasing grain yield and bioactive compounds, especially in Maled Phai.
Exploring the Diversity and Antibiogram of the Soil around a Tertiary Care Hospital and a University Precinct in Southern India: A Pilot Study
Authors: Kunhikannan Shalini , Stanton Cassandra R. , Rose Jayson , Thomas Colleen J. , Franks Ashley E. , Neelambike Sumana M. , Kumar Sumana , Petrovski Steve , Shindler Anya E.
Published: April 2023

Soil contains an enormous diversity of microorganisms and can act as a reservoir of antibiotic resistance determinants. This study identified and compared the bacterial diversity and the antimicrobial resistance profile of clinically-relevant isolates around a newly developed hospital and university precinct. Eight soil samples were collected, genomic DNA was extracted and 16S rRNA gene sequencing was performed. Bacterial isolates cultured from the soil were identified using MALDI-TOF. Antibiotic sensitivity testing (AST) was performed on a subset of isolates. The soil from both precincts were similarly diverse. Phylum Proteobacteria was prevalent in all samples and was the most abundant in one of the hospital sites. Cyanobacteria was abundant in two hospital sites closer to a sewage treatment plant. Bacterial diversity was only significantly different between two of the hospital sites. A total of 22 Gram-negative organisms were isolated by culture. AST revealed that the soil isolates from both precincts exhibited low resistance. The unidentified bacteria closer to the hospital precinct with human interactions possibly hints at the role of anthropogenic activities on the soil microbial diversity. The abundance of Proteobacteria (causing majority of human infections) and Cyanobacteria nearer to the hospital premises, comprising more immunocompromised and immunocompetent individuals, is concerning.
Causal Inference in Threshold Regression and the Neural Network Extension (TRNN)
Authors: Chen Yiming , Smith Paul J. , Lee Mei-Ling Ting
Published: April 2023

The first-hitting-time based model conceptualizes a random process for subjects’ latent health status. The time-to-event outcome is modeled as the first hitting time of the random process to a pre-specified threshold. Threshold regression with linear predictors has numerous benefits in causal survival analysis, such as the estimators’ collapsibility. We propose a neural network extension of the first-hitting-time based threshold regression model. With the flexibility of neural networks, the extended threshold regression model can efficiently capture complex relationships among predictors and underlying health processes while providing clinically meaningful interpretations, and also tackle the challenge of high-dimensional inputs. The proposed neural network extended threshold regression model can further be applied in causal survival analysis, such as performing as the Q-model in G-computation. More efficient causal estimations are expected given the algorithm’s robustness. Simulations were conducted to validate estimator collapsibility and threshold regression G-computation. The performance of the neural network extended threshold regression model is also illustrated by using simulated and real high-dimensional data from an observational study.
Use of Ethanol Injections to Create a Complete Atrioventricular Block in a Rat Model
Authors: Elgalad Abdelmotagaly , Hanafy Ahmed E. , Moctezuma-Ramirez Angel , Post Allison , John Mathews , Xi Yutao , Razavi Mehdi
Published: April 2023

Complete atrioventricular block (AVB) is an abnormal heart rhythm resulting from a defect in the cardiac conduction system. Patients with complete AVB are at risk of symptoms ranging from syncope or hypotension to cardiovascular collapse or sudden cardiac death. A reliable animal model of complete AVB is essential for understanding the mechanisms underlying the fatal hemodynamic effects and alterations in electrical conductivity associated with this arrhythmia. We evaluated the use of ethanol injections in a systematic surgical approach to create a complete AVB model in rats. We used eight Sprague Dawley rats (8 weeks old, 220 ± 30 g): four received a 70% ethanol injection in the AV node, and four received a similar injection of 0.9% sodium chloride. Our surgical approach involved performing a partial sternotomy, using the epicardial fat as a landmark for ethanol injections. Animals were followed for 7 and 14 days. Complete AVB was successfully induced in all four rats that received ethanol injections. Rats in the control group experienced a transient AVB with a return to sinus rhythm. Our study found that using 70% ethanol injections in a systematic surgical approach is a reliable, safe, and reproducible way of creating a complete AVB model in rats.
Toxicological Profile of PM from Different Sources in the Bronchial Epithelial Cell Line BEAS-2B
Authors: Melzi Gloria , Nozza Emma , Frezzini Maria Agostina , Canepari Silvia , Vecchi Roberta , Cremonesi Llorenç , Potenza Marco , Marinovich Marina , Corsini Emanuela
Published: April 2023

The toxicity of particulate matter (PM) is strictly associated with its physical-chemical characteristics, such as size or chemical composition. While these properties depend on the origin of the particles, the study of the toxicological profile of PM from single sources has rarely been highlighted. Hence, the focus of this research was to investigate the biological effects of PM from five relevant sources of atmospheric PM: diesel exhaust particles, coke dust, pellet ashes, incinerator ashes, and brake dust. Cytotoxicity, genotoxicity, oxidative, and inflammatory response were assessed in a bronchial cell line (BEAS-2B). BEAS-2B cells were exposed to different concentrations (25, 50, 100, and 150 μg/mL medium) of particles suspended in water. The exposure lasted 24 h for all the assays performed, except for reactive oxygen species, which were evaluated after 30 min, 1 h, and 4 h of treatment. The results showed a different action of the five types of PM. All the tested samples showed a genotoxic action on BEAS-2B, even in the absence of oxidative stress induction. Pellet ashes seemed to be the only ones able to induce oxidative stress by boosting the formation of reactive oxygen species, while brake dust resulted in the most cytotoxic. In conclusion, the study elucidated the differential response of bronchial cells to PM samples generated by different sources. The comparison could be a starting point for a regulatory intervention since it highlighted the toxic potential of each type of PM tested.
Unknown Organofluorine Mixtures in U.S. Adult Serum:Contribution from Pharmaceuticals?
Authors: Pennoyer Emily H. , Heiger-Bernays Wendy , Aro Rudolf , Yeung Leo W. Y. , Schlezinger Jennifer J. , Webster Thomas F.
Published: April 2023

Organofluorines occur in human serum as complex mixtures of known and unidentified compounds. Human biomonitoring traditionally uses targeted analysis to measure the presence of known and quantifiable per- and polyfluoroalkyl substances (PFAS) in serum, yet characterization of exposure to and quantification of PFAS are limited by the availability of methods and analytical standards. Studies comparing extractable organofluorine (EOF) in serum to measured PFAS using organofluorine mass balance show that measurable PFAS only explain a fraction of EOF in human serum and that other sources of organofluorine may exist. The gap in fluorine mass balance has important implications for human biomonitoring because the total body burden of PFAS cannot be characterized and the chemical species that make up unidentified EOF are unknown. Many highly prescribed pharmaceuticals contain organofluorine (e.g., Lipitor, Prozac) and are prescribed with dosing regimens designed to maintain a therapeutic range of concentrations in serum. Therefore, we hypothesize organofluorine pharmaceuticals contribute to EOF in serum. We use combustion ion chromatography to measure EOF in commercial serum from U.S. blood donors. Using fluorine mass balance, we assess differences in unexplained organofluorine (UOF) associated with pharmaceutical use and compare them with concentrations of organofluorine predicted based on the pharmacokinetic properties of each drug. Pharmacokinetic estimates of organofluorine attributable to pharmaceuticals ranged from 0.1 to 55.6 ng F/mL. Analysis of 44 target PFAS and EOF in samples of commercial serum (n = 20) shows the fraction of EOF not explained by Σ44 PFAS ranged from 15% to 86%. Self-reported use of organofluorine pharmaceuticals is associated with a 0.36 ng F/mL (95% CL: −1.26 to 1.97) increase in UOF, on average, compared to those who report not taking organofluorine pharmaceuticals. Our study is the first to assess sources of UOF in U.S. serum and examine whether organofluorine pharmaceuticals contribute to EOF. Discrepancies between pharmacokinetic estimates and EOF may be partly explained by differences in analytical measurements. Future analyses using EOF should consider multiple extraction methods to include cations and zwitterions. Whether organofluorine pharmaceuticals are classified as PFAS depends on the definition of PFAS.
Atypical Skull-Base Osteomyelitis: Comprehensive Review and Multidisciplinary Management Viewpoints
Authors: Urbančič Jure , Vozel Domen , Battelino Saba , Bošnjak Roman , Kokošar Ulčar Barbara , Matos Tadeja , Munda Matic , Papst Lea , Steiner Nejc , Vouk Matej , Zidar Nina
Published: April 2023

Atypical skull-base osteomyelitis is a rare but fatal disease that usually involves infection of the ethmoid, sphenoid, occipital, or temporal bones that form the skull base. Unlike typical (so-called otogenic), atypical skull-base osteomyelitis has no otogenic cause. Instead, some authors call atypical skull-base osteomyelitis sinonasal, since the infection most often originates from the nose and paranasal sinuses. Diagnosing and treating this disease is challenging. To assist in managing atypical skull-base osteomyelitis, a review of the most recent literature, with patient cases and multidisciplinary perspectives from otolaryngologists, neurosurgeons, radiologists, infectious disease specialists, pathologists, and clinical microbiologists, is provided in this paper.
Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making
Authors: See Kay Choong
Published: April 2023

Pneumococcal disease remains one of the major causes of severe disease in both children and adults. Severe disease may be prevented by pneumococcal polysaccharide and conjugate vaccines, which currently cover more than 20 serotypes. However, unlike routine pneumococcal vaccination in children, guidelines promote only limited pneumococcal vaccination in adults, and do not cater for decision-making for individual patients. In this narrative review, considerations for individualized decision-making are identified and discussed. This review identifies and discusses considerations for individualized decision-making, including the risk of severe disease, immunogenicity, clinical efficacy, mucosal immunity, herd immunity, concomitant administration with other vaccines, waning immunity, and replacement strains.
Construction of a Triple-Gene Deletion Mutant of Orf Virus and Evaluation of Its Safety, Immunogenicity and Protective Efficacy
Authors: Shen Zhanning , Liu Bo , Zhu Zhen , Du Jige , Zhou Zhiyu , Pan Chenfan , Chen Yong , Yin Chunsheng , Luo Yufeng , Li Huanrong , Chen Xiaoyun
Published: April 2023

Contagious ecthyma is a zoonotic disease caused by the orf virus (ORFV). Since there is no specific therapeutic drug available, vaccine immunization is the main tool to prevent and control the disease. Previously, we have reported the construction of a double-gene deletion mutant of ORFV (rGS14ΔCBPΔGIF) and evaluated it as a vaccine candidate. Building on this previous work, the current study reports the construction of a new vaccine candidate, generated by deleting a third gene (gene 121) to generate ORFV rGS14ΔCBPΔGIFΔ121. The in vitro growth characteristics, as well as the in vivo safety, immunogenicity, and protective efficacy, were evaluated. RESULTS: There was a minor difference in viral replication and proliferation between ORFV rGS14ΔCBPΔGIFΔ121 and the other two strains. ORFV rGS14ΔCBPΔGIFΔ121 induced continuous differentiation of PBMC to CD4+T cells, CD8+T cells and CD80+CD86+ cells and caused mainly Th1-like cell-mediated immunity. By comparing the triple-gene deletion mutant with the parental strain and the double-gene deletion mutant, we found that the safety of both the triple-gene deletion mutant and the double-gene deletion mutant could reach 100% in goats, while the safety of parental virus was only 50% after continually observing immunized animals for 14 days. A virulent field strain of ORFV from an ORF scab was used in the challenge experiment by inoculating the virus to the hairless area of the inner thigh of immunized animals. The result showed that the immune protection rate of triple-gene deletion mutant, double-gene mutant, and the parental virus was 100%, 66.7%, and 28.6%, respectively. In conclusion, the safety, immunogenicity, and immune-protectivity of the triple-gene deletion mutant were greatly improved to 100%, making it an excellent vaccine candidate.
Euthanasia of Dogs by Australian Veterinarians: A Survey of Current Practices
Authors: Pepper Brianne Marlene , Chan Hedia , Ward Michael P. , Quain Anne
Published: April 2023

Euthanasia techniques utilised by veterinarians impact the welfare of many dogs in their final moments. Despite euthanasia guidelines, little is known about euthanasia techniques used in practice. We administered an online survey of Australian veterinarians who had euthanised at least one dog in the previous 12 months. We found that 668 (96.8%) had euthanised a dog in the previous 12 months, almost all using intravenous pentobarbitone sodium (n = 651, 99.7%). For non-emergency euthanasia (n = 653), the majority (n = 442, 67.7%) administered a premedication or sedation prior to euthanasia versus less than half for emergency euthanasia (n = 286, 46.4%). Practices and views about euthanasia varied. Female veterinarians and veterinarians located in metropolitan regions were more likely to administer a premedication or sedation prior to non-emergency euthanasia (p < 0.05). Veterinarians in private mixed animal practices were less likely to administer a premedication or sedation prior to a non-emergency euthanasia (p < 0.05). For non-emergency and emergency euthanasia, veterinarians who worked in “other” practice types were more likely to administer a premedication or sedation than private companion animal practices (p < 0.05). The possible reasons for differences in euthanasia practices are explored, and scope for refinement is identified.
Tobacco Smoke Exposure in Pregnant Dogs: Maternal and Newborn Cotinine Levels: A Pilot Study
Authors: Pizzi Giulia , Mazzola Silvia Michela , Pecile Alessandro , Bronzo Valerio , Groppetti Debora
Published: April 2023

Active and passive smoking in pregnant women is associated with perinatal morbidity and mortality risk, including abortion, preterm birth, low birthweight, and malformations. No data are available on intrauterine exposure to smoking during pregnancy in dogs. This study aimed to fill this gap by exploring the detectability and quantity of cotinine, the major metabolite of nicotine, in maternal (serum and hair) and newborn (amniotic fluid and hair) biospecimens collected at birth in dogs. For this purpose, twelve pregnant bitches, six exposed to the owner’s smoke and six unexposed, were enrolled. A further six non-pregnant bitches exposed to passive smoke were included to investigate the role of pregnancy status on cotinine uptake. Exposed dogs, dams, and puppies had greater cotinine concentrations than unexposed ones. Although without statistical significance, serum and hair cotinine concentrations were higher in pregnant compared to non-pregnant bitches, suggesting a different sensitivity to tobacco smoke exposure during gestation. The present results provide evidence for cotinine transplacental passage in the dog. It is conceivable that fragile patients such as pregnant, lactating, and neonate dogs may be more susceptible to the harmful effects of second-hand smoke exposure. Owners should be sensitized to the risk of smoke exposure for their pets.
Local allergic rhinitis: the issue and its significance
Authors:   Astana Medical University, Astana, Republic of Kazakhstan, Rozenson R.I.
Published: April 2023

The article presents the pathogenetic mechanisms of allergic rhinitis and approaches to the allergic diagnosis of this pathology. The clinician has an opportunity to verify the presence of this particular form of rhinitis when using the following laboratory diagnostic methods: determining the level of IgE in the nasal secretion, using the basophil activation test, rhinocytogram, and other nasal cytology tests. The basophil activation test is a functional study in which flow cytometry is used to determine the expression of activation markers on basophils following the exposure to the relevant al lergen. The use of this test in diagnostics showed that it had 50% sensitivity and 93% specificity in the examination of patients with suspected sensitization to house dust allergens. Even higher sensitivity rates (66%) with equal specificity (91.7%) were found in patients with sensitization to pollen allergens.
Results of endoscopic hemostasis methods in treatment of gastrointestinal bleeding in patients with SARS-CoV-2
Authors:   SBHI Saint-Petersburg Clinical Infectious Disease Hospital named after S. P. Botkin, Saint-Petersburg, Medvedev K. V. ,   Department of Faculty Surgery named after professor A. A. Rusanov, FSBEI HE Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Aleksandrova Yu. A. ,   SBHI Saint-Petersburg Clinical Infectious Disease Hospital named after S. P. Botkin, Saint-Petersburg, Aksenova T. E. ,   SBHI Saint-Petersburg Clinical Infectious Disease Hospital named after S. P. Botkin, Saint-Petersburg, Karpova R. A. ,   SBHI Saint-Petersburg Clinical Infectious Disease Hospital named after S. P. Botkin, Saint-Petersburg, Korchak M. V. ,   SBHI Saint-Petersburg Clinical Infectious Disease Hospital named after S. P. Botkin, Saint-Petersburg, Protchenkov M. A. ,   SBHI Saint-Petersburg City Hospital No. 26, Saint-Petersburg; Department of Faculty Surgery named after professor A. A. Rusanov, FSBEI HE Saint-Petersburg State Pediatric Medical University, Saint-Petersburg
Published: April 2023

The development of gastrointestinal bleeding from erosive and ulcerative defects of the mucous membranes of the upper gastrointestinal tract, which, according to the world literature, occurs in 2–13 % of hospitalized patients with COVID-19, is a multifaceted problem that is still relevant, but has not been adequately reflected in scientific publications. The aim of the work was to study the clinical characteristics of patients with gastrointestinal bleeding on the background of SARS-CoV-2 and evaluate the methods of endoscopic hemostasis. The article analyzed cases of bleeding from the upper gastrointestinal tract in 115 patients suffering from the novel coronavirus infection. The severity of the course of COVID-19 was assessed according to the criteria of the NEWS scale, the degree of respiratory failure, and radiological data. 114 out of 115 patients had comorbidities; the most common diseases were cardiovascular diseases, endocrine pathology, chronic kidney disease, and oncopathology. The most common sources of bleeding (82 %) were acute or chronic ulcers of the stomach and/or duodenum against the background of erosive hemorrhagic lesions of the mucosa. The following methods of endoscopic hemostasis were used: endoscopic clipping, endoscopic injections, applications of hemostatic agents and solutions, and combined methods which were used more often. Hemostasis was achieved in all cases. Repeated bleeding occurred in 22 cases (19.1 %) with subsequent achievement of endo-hemostasis. Mortality was 66.95 % (77 patients), with such causes of adverse outcomes as increasing multiple organ failure, respiratory distress syndrome, and septic shock.
Laparoscopic right hemicolectomy with intracorporeal ileo-transverse anastomosis (review)
Authors:   Federal State Budgetary Institution «Ryzhikh National Medical Research Center of Coloproctology» of the Ministry of Health of Russia, Romanova E. M. , Surovegin E. S. ,   Federal State Budgetary Institution «Ryzhikh National Medical Research Center of Coloproctology» of the Ministry of Health of Russia, Shakhmatov D. G. ,   Federal State Budgetary Institution «Ryzhikh National Medical Research Center of Coloproctology» of the Ministry of Health of Russia, Sushkov O. I. ,   Federal State Budgetary Institution «Ryzhikh National Medical Research Center of Coloproctology» of the Ministry of Health of Russia
Published: April 2023

Colon cancer is one of the most common malignant tumors worldwide. The main treatment for localized colon cancer is surgery. Nowadays laparoscopic colectomies for colon cancer have advantages over open ones, as they provide better short-term results. There has been a continuous improvement in the technique of the operation, and due to the widespread use of laparoscopic stapling and cutting devices, intracorporeal anastomosis is becoming more and more accessible. This article discusses the advantages and disadvantages of various methods for the formation of ileo-transverse anastomosis in laparoscopic right hemicolectomy.
Technologies and trends of accounting, reporting and control in the conditions of development of the digital environment of public administration
Authors:   Federal State Budgetary Educational Institution of Higher Education “State University of Management”, Moscow, Russia, Blizkiy R.S. , Budaeva Yu.Zh ,   Federal State Budgetary Educational Institution of Higher Education “State University of Management”, Moscow, Russia, Dolgushkina V.A. ,   LLC “Bukhinfoservice”, Moscow, Russia, Gulua S.V. ,   PJSC “Leasing Company “EUROPLAN”, Moscow, Russia
Published: April 2023

The article deals with topical issues of accounting, reporting and control, including technologies, trends in budgetary institutions in the context of the transition of institutions to the scheme of providing accounting procedures for centralized accounting. Legal iterations, problems of state regulators in the field of research, including the regulatory framework, ensuring the methodology of accounting for documentation on electronic document management, are updated, while special attention is paid to the impact of electronic document management on the process of internal audit in the digital environment. The paradigm of technological sovereignty in legal iterations of digital transformations in the national project “Digital Economy of the Russian Federation” is proposed. In the course of the research, general scientific and specific methods were used, among which one can distinguish the method of scientific abstraction, institutional method, methods of analysis (systemic, legal, functional, structural, economic) and synthesis, accounting method, logical method, classification method. The research results reflect the depth of the specifics of systematization, interpretation of conceptual trends in the development of the digital accounting environment reflected in the regulations of the Ministry of Finance of Russia, including centralization, accounting methodology, reporting and control in the public sector. The algorithm of optimal inclusion of the public sector in the interoperable mechanism of development, control and maintenance of smart control, electronic duplicates, “digital storages” is presented. The features of the introduction of modern information and communication technologies into the system of functioning of budgetary institutions and electronic document management systems in the current conditions of socio-economic development of society are noted. The research results will be useful to a wide range of readers interested in the processes of digitalization and centralization of accounting of budgetary institutions.
Two-phase rehabilitation of patients with a forced position of the lower jaw: a clinical case
Authors: Fadeev R. A. , Timchenko V. V.
Published: April 2023

Relevance. Malocclusion correction in children very frequently requires several orthodontic appliances throughout the entire treatment period. The high prevalence of dental abnormalities in childhood determines the issue's relevance.

Clinical cases' description. The article presents summaries from the records of the patients who presented for orthodontic care with malocclusion complicated by the forced position of the lower jaw. The authors implemented a two-phase orthodontic treatment protocol and achieved acceptable aesthetic and functional results.

Conclusion. Laboratory-made plates with occlusal pads in the first phase of treatment of patients with mixed dentition contributes to the normalization of the lower jaw position and the alignment of the occlusal plane. In the second phase of orthodontic treatment, a standard silicone aligner allows for the improvement of dental arch relationship in the vertical, sagittal and transversal planes, normalization of dental arch form, and the correction of displaced teeth.
Saha (Yakut) Türklerinin İlk Edebî Eseri "Axtıılar (Hatıralar)"daki Halk Bilimi Unsurları
Authors: ERSOZ Murat
Published: April 2023

Axtıılar, Afanasiy Yakovleviç Uvarovskay (1800-1862) tarafından yazılmış Sahaca (Yakutça) ilk edebî eserdir. Uvarovskay, üst düzey kamu görevlerinde bulunmuş ve bu sırada Yakut halkının sevgisine mazhar olmuş bir bürokrattır. İyi eğitim almıştır, entelektüel birikimi yüksektir. Kuzeydoğu Sibirya halklarının kültürlerine ve yaşantılarına vâkıftır, Yakut yurdu memleketidir, Yakutçayı ise ana dili olarak görür. O, bu çalışmaya konu olan eserini Mart 1846’da Türklük bilimi uzmanı Otto Nikolayeviç Böhtlingk’in ricasıyla kaleme almaya başlar ve 8 Kasım 1846’da tamamlar. Onun Axtıılar diye adlandırılan bu eserini yazmasındaki amacı, Böhtlingk’in Yakut dili hakkında yapmakta olduğu çalışmasına yardımcı olmak ve bu sayede Yakut dilinin korunmasına katkı sağlamaktır. Uvarovskay, eserinde çocukluğundan itibaren başından geçen belli başlı olayları konu alır. O, hayatını hüzün dolu ve kıymetsiz olarak değerlendirir. Fakat onun yaşam hikâyesi Saha (Yakut) folkloru açısından paha biçilemez kıymette malzemeler barındırır. Üstelik çalışmasının sonuna Yakut hayatı ve folkloru üzerine notlar ilave eder. Bu notlar, Yakutlarla ilgili yazılmış ilk derli toplu folklorik tespitlerdir. Bu yüzden Yakutistan’ın ilk halk bilimcisi olarak kabul edilir. Onun yazdığı bu kitap, XIX. yy.’ın ortasında tam metin olarak Almancaya, hemen ardından da özeti Fransızcaya (1860) çevrilir. Bu sayede yabancı kültür ve bilim insanları Yakutların gelenek ve göreneklerini güvenilir bir kaynaktan öğrenme fırsatı bulurlar. Burada işlenen konular karşılaştırmalı halk bilimi çalışmaları açısından önemlidir. Bu makalede Axtıılar’da işlenen halk bilimi unsurları tespit edilip içeriklerine göre tasnif edilmiş, peşinden de tahlil edilmiştir. Bu suretle XIX yy. Yakut folklorik hayatı bu eser üzerinden sistematik bir biçimde ortaya konulmaya çalışılmıştır.
General and special education teachers’ attitudes towards evidence-based practice
Authors: Rüger Lea , Scheer David
Published: April 2023

In the context of special and inclusive education, the implementation of evidence-based practice is important to provide equal access to effective and efficient education for students with and without disabilities. However, there is a relevant research-practice gap in this area. To better understand how teachers can be supported in using evidence-based interventions and what training and development needs exist, a questionnaire on attitudes towards evidence-based practice was developed and piloted with a sample of 809 teachers in Germany. In one half of the sample, the factor structure was determined using categorical exploratory factor analysis and this was confirmed in the second half of the sample using categorical confirmatory factor analysis. A good model fit, and good factor reliability were found. The instrument is measurement invariant between general and special education teachers. As expected, we found more positive attitudes towards evidence-based practice among special needs teachers. Significant differences between different age groups were not found. Based on the findings, it can be assumed that the measurement instrument is suitable to be used in implementation research as well as in the evaluation of initial and in-service teacher training programmes. Further studies on convergent, divergent, and prognostic validity are necessary.
Claude-Nicolas Ledoux ve Le Corbusier’in İdeal Kent Arayışları ve İşçi Yerleşkeleri: Saline Royale ve Cité Frugés Tasarımları
Authors: ECE KAYA Birsu , ÖRMECİOĞLU Hilal Tuğba
Published: April 2023

Daha iyi kentsel ve toplumsal yaşam arayışı ile ortaya çıkan ütopyacı düşünce, mekandaki yansımaları için mimarlığa başvururken; mimarlık için ütopya düşüncesi, ideal mekânı ve yaşamı tasarlamak için aracı olmaktadır. Biri 18. yüzyılda, diğeri 20. yüzyılda yaşamış olan Claude-Nicolas Ledoux ve Le Corbusier, ideal toplum ve kent arayışları kapsamında çeşitli düşünceler geliştirmiş ve bu düşüncelerini mimari tasarımlarına yansıtmaya çalışmışlardır. Ledoux’nun Saline Royale d’Arc-et-Senans (Kraliyet Tuzhanesi) ve Le Corbusier’in Cité Frugés de Passac (Fruges Kasabası) tasarımları sanayi ve teknolojinin farklı evrelerde olduğu iki ayrı yüzyılda, değişen yaşam koşulları ve bakış açılarıyla tasarlanmış işçi yerleşkeleridir. Seçilen örneklerin incelenmesi ve karşılaştırılması, farklı yüzyıllarda egemen olan toplumsal, teknolojik ve ekonomik koşulların işçi yerleşkesi tasarımlarına etkilerini tartışmayı mümkün kılmaktadır. Bu bağlamda çalışmanın amacı, iki yüzyıl arayla tasarlanmış işçi yerleşkeleri üzerinden mimarlıktaki ideal kent ve toplum anlayışının değişimini ve dönüşümünü gözlemlemektir. Çalışmadan elde edilen sonuca göre, iki mimarın mimarlık düşünceleri ve pratiği, tarihsel bir sürekliliğin varlığını göstermektedir. Bununla birlikte yine de bu işçi yerleşimlerinin plan şemaları, yapım teknikleri, ortak ve özel mekân tasarımları, sosyal imkanları bakımından taşıdıkları farklılıklar, tasarlandıkları dönemin toplumsal, ekonomik ve teknolojik özelliklerini yansıtmakta ve böylece iki yüzyıl arasındaki farklı teknolojilerin, üretim ve tüketim sistemlerinin, politik ve toplumsal yapıların mimarlık düşüncesine ve uygulamasına yansımasını görünür kılmaktadır.
Of Racist Philosophers and Ravens
Authors: Gill Michael B.
Published: April 2023

How can historians of philosophy justify spending the preponderance of their professional lives writing about historical philosophers who held racist views? I use the controversy over University of Edinburgh’s David Hume Tower as a jumping-off place for discussion of this issue. I argue that worthwhile philosophical ideas in historical philosophers can be conceptually isolated from their racist views.
Non-Consensual Vaccination and Medical Harassment: Giving Vaccine Refusers Their Due1
Authors: Capraru Mihnea D. I.
Published: April 2023

This article argues that non-consensual vaccination is morally impermissible, for the same reasons for which sexual assault is not permissible. Likewise, mandatory vaccination is morally akin to sexual harassment, and therefore is not to be allowed.
Cost-Effective Acoustic Feedback Cancellers for Digital Hearing Aids
Authors: Eren Yusuf , Çolak Güvenç Buket , Mengüç Engin
Published: April 2023

By drawing inspiration from the online censoring (OC) strategy that has significantly contributed to the adaptive processing of big data streams, we develop two prediction error method (PEM) based AFC (PEMAFC) systems in this paper, called OC-PEMAFC-1 and OC-PEMAFC-2. 
On the Convex Hull of the Achievable Capacity Region of the Two User FDM OMA Downlink
Authors: Belső Zoltán , Pap László
Published: April 2023

In multiple access channel systems, such as a mobile communication network, it is important to determine how to share the available resources (for example bandwidth and power) among the users. In recent years, one of the promising scheme is Non-Orthogonal Multiple Access (NOMA), where, unlike the traditional Orthogonal Multiple Access, OMA solution, signals for the different users overlap in some domain (power-domain NOMA, code-domain NOMA, etc). In order to evaluate the performance of any NOMA scheme, we need to compare the achievable bit rates of the users (the capacity region) to an OMA case with comparable parameters (for example, same total bandwidth, same total power and same channel conditions, etc). To make this comparison, we first need to know the capacity region for the OMA cases. Many papers make such comparison without detailing the derivation of the capacity region of the OMA case they compare to [1], [2], [3], [4]. In some cases, we have only one free parameter to choose (for example in uplink frequency division multiplexing systems for two users, it is the bandwidth ratio between the users), and the achievable capacity can be directly calculated for both users depending on the single parameter (hence the boundary of the capacity region is trivial). In other cases, such as downlink frequency division multiplexing systems, even for only two users, we have to allocate optimally two resources between the users: the bandwidth and the base station’s available power. Hence, it is far from being trivial to determine which combination is better and where the boundary of the capacity region is. In this paper, we provide a derivation for that case.
Techno-economic analysis on Mobile Network Sharing contribution to social welfare at 4G-5G area in Hungary
Authors: Földes Gábor
Published: April 2023

Telecommunication sector faces to parallel investments into both fixed and mobile (5G) networks, however return on investments lag behind profit expectations. Co-investment, like mobile network sharing is a cost efficiency enabler that may accelerate price decrease, may allow earlier, higher coverage and may improve capacity and quality parameters, like download speed, therefore altogether contributes to social welfare increase. The purpose of this paper to assess the Hungarian mobile network sharing that not cleared by the competition regulator, however has been placed in unchanged form for 8 years. The research question is to assess what is the connection between mobile network sharing and social welfare improvement at 4G - 5G mobile broadband rollout. The finding is that, majority of network sharing procompetitive effects allowing benefits, but anticompetitive effects not causing marked distortion. Affordable connectivity prices for information society roots in operators’ cost efficiency, however further research required to assess proper level of efficiency gains pass through to customers and appropriate level of access pricing to shared infrastructure for other rival operators in Hungary. Mobile Network Sharing’s benefits may outweigh potential drawbacks, but due to lack of regulatory clearance, 5G rollout launched without sharing, causing social welfare loss. The originality of the empirical research is despite network sharing not cleared, procompetitive advantages may outweigh anticompetitive ones.
The Effectiveness of Cement and Lime as Stabilizers for Subgrade Soils with High Plasticity and Swelling Potential
Authors: Okonkwo Ugochukwu Nnatuanya , Kennedy Charles
Published: April 2023

This study investigated the effects of cement and lime on the mechanical properties of subgrade soils, which are challenging to stabilize due to high plasticity and swelling potential. The study found that both cement and lime are effective stabilizing agents that increase the OMC, with cement being more effective in reducing the OMC of black cotton soil. The engineering properties of stabilized Chokocho subgrade soil were also evaluated, and the use of cement and lime as stabilizers was found to be effective in improving soil characteristics for subgrade applications. This was indicated by increased maximum dry density values, reduced plasticity index values, and increased California bearing ratio and unconfined compressive strength values. The chemical composition test demonstrated that calcium plays a significant role in soil stabilization, while aluminum can potentially affect soil stability negatively. Other elements such as magnesium, iron, silicon, zinc, and nickel contribute positively to soil stability. The low amounts of lead, copper, manganese, potassium, sulfur, and titanium present in the soil indicate a minor contribution to soil stabilization, but their impact on soil properties and plant growth cannot be ignored. Overall, the study highlights the importance of considering specific soil types and conditions when undertaking soil stabilization projects. The findings provide valuable information for future research in this field, particularly in investigating the effectiveness of other stabilizers and their interactions with specific soil types. The use of cement and lime in soil stabilization is an effective method for enhancing the strength and durability of weak soils, as shown by the reduction in plastic limit values observed in the stabilized soil samples. The appropriate content of cement and lime to use in soil stabilization could inform standards and codes for soil stabilization.
Pengaruh Return Saham, Tata Kelola Perusahaan, Kinerja Keuangan terhadap Opini Audit Going Concern pada Perusahaan Manufaktur Sektor Industri Barang Konsumsi
Authors: Fungki Diana , Kintadi Cris , Pramukty Rahmat
Published: April 2023

Kelangsungan hidup perusahaan menjadi sorotan penting bagi pihak-pihak yang berkepentingan (stakeholder) di dalam maupun di luar perusahaan, terutama bagi para investor. Para investor melakukan investasi untuk membiayai kegiatan operasional perusahaan, oleh karena itu investor harus terlebih dahulu memperhatikan kondisi keuangan mengenai kelangsungan hidup (going concern) perusahaan, kondisi keuangan perusahaan tertuang dalam laporan keuangan perusahaan. Penelitian ini bertujuan untuk mengetahui pengaruh return saham, tata kelola perusahaan, dan kinerja keuangan terhadap opini audit going concern. Penelitian ini menggunakan metode pendekatan kuantitatif dan sumber data yang digunakan adalah data sekunder. Populasi yang digunakan adalah perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia 2019-2021. Teknik pengambilan sampel dalam penelitian ini menggunakan metode purposive sampling diperoleh 19 perusahaan telah memenuhi kriteria sampel yang telah ditentukan. Teknik analisis data yang digunakan adalah statistik deskriptif dengan bantuan Eviews 12. Riset terdahulu atau riset yang relevan sangat penting dalam suatu riset atau artikel ilmiah. Riset terdahulu atau riset yang relevan berfungsi untuk memperkuat teori dan fenomena hubungan atau pengaruh antar variable. Artikel ini mereview faktor-faktor yang memengaruhi opini audit going concern, yaitu return saham, tata kelola perusahaan dan kinerja keuangan, suatu studi literatur Auditing. Tujuan penulisan artikel ini guna membangun hipotesis pengaruh antar variabel untuk digunakan pada riset selanjutnya. Hasil artikel literature review ini adalah:  1) return saham berpengaruh terhadap opini audit going concern; 2) tata kelola perusahaan berpengaruh terhadap opini audit going concern; dan 3) kinerja keuangan berpengaruh terhadap opini audit going concern.
Towards a Pedagogics of Epiphany
Authors: Mason Paul
Published: April 2023

This article begins by focusing on critiques of the ideology and practice of neoliberalism in universities, nation-wide and globally. The argument proceeds to analyse alternative or counter-neoliberal strategies of reading, writing, and teaching propounded by selected scholars. My analysis reveals that, although these scholars argue the necessity of developing and putting into practice pedagogical strategies that contest those that are driven by the neoliberal agenda, they do little more than gesture toward implementation of these. By way of redressing this lack, I present a case study that indicates specific tactics for “slipping under the neoliberal radar”. This leads to a discussion of what I consider to be a crucial academic concern – the practice, or the art, of reading, as expressed by George Steiner (1978), John Williams in his novel Stoner (1965), and Éammon Dunne in an analysis of this novel (2016). It is my intention to show how these texts inspired me to concoct what I call a pedagogics of epiphany. I conclude my argument by explaining what I mean by this concept, and the ways in which its implementation might reflect a simultaneously radical and circumspect orientation toward the ongoing project of “doing academia differently”.
An almost Complex Structure with Norden Metric on the Phase Space
Authors: Bejan Cornelia-livia , Nakova Galia
Published: April 2023

On the total space of the cotangent bundle of a Riemannian manifold, we construct a semi-Riemannian metric $G$, with respect to which an almost complex structure $J$ introduced by Oproiu and Poro\cb{s}niuc is self-adjoint. The structure $(J,G)$ turnes out to be an almost complex structure with Norden metric (this notion is known in the literature from Norden's papers). The semi-Riemannian context is different from the Riemannian one, as it is pointed out by Duggal and Bejancu in their monograph. We study this structure and provide some necessary and sufficient conditions for it to be a K\"ahler structure with Norden metric.
Agmatine as a Novel Treatment Option for Neuropathies: Experimental Evidences
Authors: Dhokne Mrunali D. , Dixit Madhura P. , Kale Mayur B. , Aglawe Manish M. , Umekar Milind J. , Taksande Brijesh G.
Published: April 2023

N-methyl-D-aspartate receptor (NMDAR) antagonist, a subclass of glutamate receptors or nitric oxide synthase (NOS) inhibitors, prevents neuronal plasticity. However, neural plasticity plays a major role in the pain caused by inflammation and neuropathy, providing clinical opportunities for the use of NOS inhibitors and NMDAR antagonists in the treatment of chronic pain. The neuromodulator agmatine has both NOS inhibitory and NMDAR antagonistic activity, and it controls a range of neurotransmitters and signaling pathways in the brain and spinal cord. The effects of agmatine on pain modulation are described and explored in this article, along with a potential mechanism of action for these effects. We specifically offer evidence to support further clinical and pre-clinical trials looking into agmatine as a novel therapeutic agent for neuropathic pain.