bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Tingkat Pemahaman Dan Pertimbangan Pasar Kerja Mahasiswa Jurusan Akuntansi Universitas Potensi Utama Dalam Mempengaruhi Pemilihan Karir Sebagai Akuntan Publik
Authors: Siregar Ratih Anggraini , Siregar Febby Yoana
Published: January 2021

Akuntan berperan sebagai tulang punggung utama dalam profesi akuntansi. Untuk memperoleh gelar sebagai akuntan harus menempuh pendidikan di jurusan akuntansi pada suatu universitas serta lulus Pendidikan Profesi Akuntansi (PPAk). Salah satunya yaitu akuntan publik, akuntan publik merupakan para akuntan yang berprofesi sebagai auditor atau konsultan pada kantor akuntan publik atau jasa akuntansi. Tujuan penelitian ini adalah untuk menganalisis pengaruh tingkat pemahaman dan pertimbangan pasar kerja mahasiswa jurusan akuntansi Universitas Potensi Utama terhadap pemilihan karir sebagai akuntan publik. Sampel dalam penelitian ini terdiri dari jumlah responden Mahasiswa/I Universitas Potensi Utama sebanyak 100 orang. Metode analisis yang digunakan metode regresi linier berganda. Berdasarkan uji t pertimbangan pasar kerja (X1) berpengaruh terhadap pemilihan karir sebagai akuntan publik (Y) dengan nilai thitung (2,449) lebih besar daripada ttabel (1,661) dan pertimbangan pasar kerja (X2) berpengaruh terhadap pemilihan karir sebagai akuntan publik (Y) ) dengan nilai thitung (21,614) lebih besar daripada ttabel (1,661). Berdasarkan uji f pemahaman mahasiswa (X1) dan pertimbangan pasar kerja (X2)berpengaruh secara simultan terhadap pemilihan karir sebagai akuntan publik (Y) dengan nila fhitung 689,483 lebih besar dari ftabel 3,09 dengan besaran pengaruh 93,4% dan sisanya dipengaruhi variabel lain yang tidak diteliti pada penelitian ini.
Perancangan dan Implementasi Aplikasi Sistem Pemantauan Helm Pendeteksi Kantuk Berbasis Website
Authors: Lanes Yesaya Thomas Alfa
Published: January 2021

Tidur singkat atau biasa dikenal microsleep adalah kondisi kantuk yang menyebabkan seseorang tidak merespon lingkungan sekitar selama sepersekian detik. Kondisi kantuk tersebut sering terjadi pada pengendara sepeda motor. Saat ini, informasi kondisi kantuk pengendara tidak dapat diketahui secara langsung oleh pihak keluarga pengendara. Pada jurnal ini dibahas perancangan dan implementasi aplikasi sistem pemantauan dan catatan riwayat kantuk pengendara berbasis website menggunakan sensor otak yang disematkan pada helm pengendara. Data dari sensor otak diterima oleh mikrokontroler yang terhubung dengan jaringan internet dan dikirimkan ke database website secara realtime. Hasil keluaran berupa tampilan dinamis grafik dan tabel pada halaman website www.unsikahelpin.xyz yang dapat diakses secara online oleh pihak keluarga pengendara, dan tersedia fitur penyaringan dengan rentang tanggal di hari-hari sebelumnya untuk menampilkan jam dan tanggal ketika pengendara mengalami kantuk. Data riwayat kantuk pengendara dapat disimpan menjadi berkas dokumen dalam format PDF.
PERLINDUNGAN HUKUM BAGI ANAK AKIBAT KONTEN KEKERASAN YANG TERDAPAT DALAM SITUS YOUTUBE
Authors: Nabila Nabila
Published: January 2021

Tujuan dari penelitian ini adalah untuk mengetahui hak anak atas informasi yang ditayangkan melalui konten situs youtube bagi perkembangan anak dan mengetahui bentuk perlindungan hukum bagi anak akibat konten negatif yang memiliki unsur kekerasan dalam situs youtube. Jenis penelitian yang di gunakan dalam penelitian ini adalah yuridis normatif. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan perundang-undangan (statute approach) dan pendekatan konseptual (conceptual approach), metode pengumpulan bahan hukum dilakukan melalui studi kepustakaan. Sedangkan metode analisis bahan hukumnya dilakukan secara deskriptif kualitatif. Banyaknya dampak negatif dari tayangan atau konten yang ditonton didukung dengan data dari Komisi Perlindungan Anak Indonesia (KPAI) mencatat selama 4 tahun terakir jumlah kekerasan kepada anak terus meningkat. Bentuk perlindungan hukum anak terhadap konten negatif yang memiliki unsur kekerasan dalam situs youtube terdiri dari perlindungan hukum yang bersifat preventif dan perlindungan hukum yang bersifat represif. Keywords: Perlindungan Anak, Konten Kekerasan, Youtube
ESENSI PERALIHAN HAK KEPEMILIKAN MELALUI JUAL BELI ATAS TANAH SESUAI UNDANG UNDANG POKOK AGRARIA NOMOR 5 TAHUN 1960
Authors: Suwardi Suwardi , Atmoko Arief Dwi
Published: January 2021

Ruang lingkup agararia, dengan pemberlakuan  Undang-Undang Pokok Agraria Nomor 5 Tahun 1960 terkait Peraturan Dasar Pokok-Pokok Agraria yang disebut undang-undang atau disebut juga Undang-Undang Pokok Agraria. Dalam bidang pertanahan telah terjdi unifikasi yang mana terkait jual beli tanah yang khususnya hukum barat membagi dua yang dianggap suatu perbuatan hukum dalam perjanjian  jual beli dimana kedua pihak saling berjanji untuk melakukan suatu perbuatan hukum dan tunduk pada ketentuan Buku III Kitab Undang Undang Hukum Perdata mengenai perikatan levering, dimana telah terjadi perbuatan hukum dengan diserahkannya kebendaan dari pihak penjual kepada pihak pembeli dan hal tersebut merupakan ketentuan yang tunduk pada Buku II Kitab Undang Undang Hukum Perdata terkait benda. Karena tindakan jual beli adalah merupakan proses terjadinya peralihan hak atas tanah, yang mana obyek tanah merupakan obyek kebendaan yang telah diatur secara khusus kedalam beberapa peraturan perundang-undangan di Indonesia, untuk itu atas semua perbuatan hukum yang ada hubungannya dengan obyek tanah, maka akan terikat dengan peraturan perundang-undangan tersebut.Kata kunci  :  Esensi peralihan hak melalui  jual beli
PROBLEMS RELATED WITH IMPLEMENTATION OF ECONOMIC SPECIALTY PROGRAMS IN PEDAGOGICAL HIGHER EDUCATIONAL INSTITUTIONS
Authors:   KSPU named after V.P. Astafiev, VLADIMIROVA O.N. , GAVRILCHENKO G.S. , CHASHCHINA O.V. ,   Surikov Secondary School No. 1
Published: January 2021

Statement of the problem. The highest degree of relevance of economic education in the dynamics of the development of the “new economy” in the country requires modern approaches to the formation of a creative personality, both teachers and students who are able to understand the depth of relations among economic entities. Reference to bibliographic sources shows that the problems of teaching economic disciplines in the preparation of bachelors in pedagogical universities are practically not covered in scientific and periodical literature. The purpose of the article is to identify and systematize the problems of organizing and implementing career guidance activities and the educational process of training bachelors in the direction of 44.03.01 Pedagogical education, Economic specialty. The methodological basis of the research is represented by a combination of general scientific and special methods. As a theoretical basis, the provisions of economic theory and psychological theories are used. Research results. The authors focus on the role and importance of economic education, highlighting blocks of system-wide and specific problems in the preparation of bachelors, show the need to improve the relationship between theory and practice, increase the requirements for teaching economic disciplines through improving organization of the educational process at the secondary school level, and improving the quality of methodological components. The results of the analysis of a teaching process allow us to state that in general, the status of a teacher in the country is underestimated, there is no unity of interests between the labor market and higher education, and the practical orientation of economic education is insufficient. Conclusion. It is possible to solve the problems of implementing economic programs in pedagogical higher educational institutions at the state and local levels. It is necessary to develop a unified concept of economic education, covering the triad of preschool institutions-secondary school-university, to coordinate and use the capabilities of the administrative building.
PROFESSIONAL PORTRAIT OF A SUPERVISOR OF A REGIONAL UNIVERSITY MASTER’S PROGRAM
Authors:   KSPU named after V.P. Astafiev, DYACHUK A.A. , BOCHAROVA Yu.Yu. ,   KSPU named after V.P. Astafiev
Published: January 2021

Statement of the problem and purpose of the article. An increase in the number of master’s programs, the problem of sustainable development of students, the attraction of employers, the introduction of modern teaching technologies actualizes the management of educational programs. The article examines the problem of personnel and academic leadership of supervisors of master’s programs in regional universities in order to determine their distinguishing socio-demographic and professional characteristics. The research methodology is based on conceptual works to study the mission of a modern university, academic leadership and human resources, principles of master’s programs design based on learning outcomes. Professional and socio-demographic characteristics were studied using a questionnaire survey of academic staff from 16 regional universities. As a result of a comparative analysis, a professional portrait of the program supervisor was compiled. Research results. The socio-demographic and professional characteristics of supervisors of different types of programs that distinguish them from an academic staff are revealed. It is shown that supervisors are characterized by a combination of research and training, the priorities of which vary depending on the type of programs; participation in the development of educational programs. Differences are noted depending on the type of a program: academic or applied. Conclusion. A supervisor of master’s program becomes one of the key factors in the development of the master’s program, the activity of which determines the need to develop special mechanisms for management support.
Pengaruh Beban Penggilingan terhadap Kuat Tarik Kertas Seni dari Tandan Kosong Nipah dan Pelepah Pisang
Authors: Sucahyono Agung Eko
Published: January 2021

Penggunaan bahan non-kayu sebagai alternatif dalam pembuatan kertas seni sangat dibutuhkan. Namun, kualitas kertas yang dihasilkan seringkali cukup rendah dari sisi kekuatan tariknya. Salah satu alat yang digunakan untuk meningkatkan kualitas kertas seni adalah beater machine. Penelitian ini menggunakan tandan kosong nipah (Nypa fruticans) dan batang pisang (Musa sapientum) sebagai bahan baku. Penelitian ini bertujuan untuk mengetahui hubungan antara penambahan beban pada mesin beater terhadap kuat tarik kertas seni. Metode yang digunakan adalah rancangan acak lengkap dengan variabel bebas yaitu variasi campuran dan berat pembebanan pada mesin beater. Hasil penelitian menunjukkan bahwa besar pembebanan pada mesin beater berpengaruh terhadap peningkatan kualitas kertas seni, sedangkan komposisi bahan tidak terlalu berpengaruh terhadap kualitas kertas. Kualitas kertas yang optimal diperoleh pada proporsi bahan baku pelepah nipah dengan campuran pelepah batang pisang 60%:40% dan berat pembebanan 3,9 kg, dengan nilai ketahanan tarik 4,24 kN/m atau 4.240 N/m.Kata kunci: kertas seni, mesin beater, nipah Effect of Refining Load on The Tensile Strength of Nypa and Banana Trunk Art PaperAbstractThe use of non-wood materials as an alternative in making of art paper is needed. However, the quality of the resulting paper is often quite low in terms of its tensile strength. One of the tools used to improve the quality of art paper is a beater machine. This research used nypha and banana trunk as raw material. This study aims to determine the relationship between the addition of load on the beater machine to the tensile strength of art paper. The method used is a randomized complete design with independent variables of variations in mixture and weight of loading on the beater machine. The results showed that the loading of the beater machine had an effect on improving the quality of art paper, while the composition of the material did not significantly affect the quality of the paper. Optimal paper quality was obtained from the proportion of nypa and banana trunk of 60%:40% and load weight of 3,9 kg, where the tensile strength was 4.24 kN/m or 4,240 N/m.Keywords: art paper, beater machine, nypa
Analisis Motor Ability Mahasiswa Pendidikan Jasmani
Authors: Zulrafli  , Kamarudin
Published: January 2021

In producing good and quality learning in sports education, it needs to be equipped with good motoric movements in order to achieve goals and follow the learning contained in the physical education curriculum, so that the expected graduates can be achieved. This study aims to determine the level of motor skills of physical education students of Universitas Islam Riau. This research is a quantitative descriptive study, the method used is a survey method in the form of tests and measurements to physical education students. The population used in this study was all physical education students in semester 1 of the 2019/2020 academic year with a total of 224 people. While the sample of 144 people was selected by random sampling. The instrument used was the motor ability test from Harol M. Barrow in the form of a test battery with a validity coefficient of 0.92 with a series of tests; wall pass, basketball throw, broad jump and 4.sec. The results of the research on the level of motor skills of physical education students at the Universitas Islam Riau were mostly in the moderate category.
Evaluating the Benefits of Kinetic Monte Carlo and Microkinetic Modeling for Catalyst Design Studies in the Presence of Lateral Interactions
Authors: Li Xiao , Grabow Lars
Published: January 2021

Popular computational catalyst design strategies rely on the identification of reactivity descriptors, which can be used along with Brønsted−Evans−Polanyi (BEP) and scaling relations as input to a microkinetic model (MKM) to make predictions for activity or selectivity trends. The main benefit of this approach is related to the inherent dimensionality reduction of the large material space to just a few catalyst descriptors. Conversely, it is well documented that a small set of descriptors is insufficient to capture the intricacies and complexities of a real catalytic system. The inclusion of coverage effects through lateral adsorbate-adsorbate interactions can narrow the gap between simplified descriptor predictions and real systems, but mean-field MKMs cannot properly account for local coverage effects. This shortcoming of the mean-field approximation can be rectified by switching to a lattice-based kinetic Monte Carlo (kMC) method using cluster expansion representation of adsorbate−adsorbate lateral interactions.Using the prototypical CO oxidation reaction as an example, we critically evaluate the benefits of kMC over MKM in terms of trend predictions and computational cost when using only a small set of input parameters. After confirming that in the absence of lateral interactions the kMC and MKM approaches yield identical trends and mechanistic information, we observed substantial differences between the two kinetic models when lateral interactions were introduced. The mean-field implementation applies coverage corrections directly to the descriptors, causing an artificial overprediction of the activity of strongly binding metals. In contrast, the cluster expansion in kMC implementation can differentiate among the highly active metals but it is very sensitive to the set of included interaction parameters. Considering that computational screening relies on a minimal set of descriptors, for which MKM makes reasonable trend predictions at a ca. three orders of magnitude lower computational cost than kMC, the MKM approach does provide a better entry point for computational catalyst design.
Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy
Authors: Yi Xiaoqing , Hu Jingjing , Jun Dajung , Lou Xiaoding , Zhao Zujin , Xia Fan , Tang Ben Zhong
Published: January 2021

Nowadays, aggregation-induced emission luminogens (AIEgens) with reactive oxygen species (ROS) generating ability have been used as photosensitizers for imaging guided photodynamic therapy (PDT). To achieve enhanced antitumor outcomes, combining AIEgens-based PDT with chemotherapy is an efficient strategy. However, the therapeutic efficiency is hampered by the limited cellular uptake efficiency and the appropriate light irradiation occasion. In this paper, a self-guiding polymeric micelle (TB@PMPT) composed of two AIE photosensitizers and a reduction-sensitive paclitaxel prodrug (PTX-SS-N3) was established for enhanced chemo-photodynamic therapy by a dual-stage light irradiation strategy. When the micelles were accumulated in tumor tissues, the first light irradiation (L1, 6 min) was utilized to facilitate cellular uptake by “photochemical internalization” (PCI). Then the intracellular glutathione (GSH) would induce the PTX release, micelles disassembly and the aggregation state change of AIEgens. The fluorescence signal change of two AIEgens-based ratiometric fluorescent probe could not only precisely guide the second light irradiation (L2, 18 min) for sufficient ROS production, but also monitor the non-fluorescent drug PTX release in turn. Both in vivo and in vitro studies demonstrated that the dual-stage light irradiation strategy employed for TB@PMPT micelles exhibited superior therapeutic effect than only 24-min continuous light irradiation.
Combining Molecular Dynamic Information and an Aspherical-Atom Data Bank in the Evaluation of the Electrostatic Interaction Energy in Multimeric Protein-Ligand Complex: A Case Study for HIV-1 Protease
Authors: Kumar Prashant , Dominiak Paulina
Published: January 2021

Computational analysis of protein-ligand interactions is of crucial importance for drug discovery. Assessment of ligand binding energy allows us to have a glimpse on the potential of a small organic molecule to be a ligand to the binding site of a protein target. Available scoring functions such as in docking programs, we could say that they all rely on equations that sum each type of protein-ligand interactions to model the binding affinity. Most of the scoring functions consider electrostatic interactions involving the protein and the ligand. Electrostatic interactions contribute one of the most important part of total interaction energies between macromolecules, unlike dispersion forces they are highly directional and therefore dominate the nature of molecular packing in crystals and in biological complexes and contribute significantly to differences in inhibition strength among related enzyme inhibitors. In this paper, complexes of HIV-1 protease with inhibitor molecules (JE-2147 and Darunavir) have been analysed using charge densities from a transferable aspherical-atom data bank. Moreover, we analyse the electrostatic interaction energy for an ensemble of structures using molecular dynamic simulation to highlight the main features related to the importance of this interaction for binding affinity.
Toughening Hydrogels Through Force-triggered Chemical Reactions that Lengthen Polymer Strands
Authors: Wang Zi , Zheng Xu Jun , Ouchi Tetsu , Kouznetsova Tatiana , Beech Haley , Av-Ron Sarah , Bowser Brandon , Wang Shu , Johnson Jeremiah , Kalow Julia , Olsen Bradley , Gong Jian Ping , Rubinstein Michael , Craig Stephen
Published: January 2021

The utility and lifetime of materials made from polymer networks, including hydrogels, depend on their capacity to stretch and resist tearing. In gels and elastomers, those mechanical properties are often limited by the covalent chemical structure of the polymer strands between cross-links, which is typically fixed during the material synthesis. Here, we report polymer networks in which the constituent strands lengthen through force-coupled reactions that are triggered as the strands reach their nominal breaking point. Reactive strand extensions of up to 40% lead to hydrogels that stretch 40-50% further than, and exhibit tear energies twice that of, networks made from analogous control strands. The enhancements are synergistic with those provided by double network architectures, and complement other existing toughening strategies.
Estimating the Geothermal Electricity Generation Potential of Sedimentary Basins Using genGEO (The Generalizable GEOthermal Techno-Economic Simulator)
Authors: Adams Benjamin , Ogland-Hand Jonathan , M. Bielicki Jeffrey , Schädle Philipp , Saar Martin
Published: January 2021

AbstractSedimentary basins are ubiquitous, naturally porous and permeable, and the geothermal heat in these basins can be extracted with geologic water or CO2 and used to generate electricity. Despite this, the broad potential that these formations may have for electricity generation is unknown. Here we investigate this potential, which required the creation of the generalizable GEOthermal techno-economic simulator (genGEO). genGEO is built with only publicly available data and uses five standalone, but integrated, models that directly simulate all components of geothermal power plants to estimate electricity generation and cost. As a result of this structure, genGEO, or a portion of it, can be applied or extended to study any geothermal power technology. In contrast, the current techno-economic tools for geothermal power plants rely on characterizations of unpublished ASPEN results and are thus not generalizable enough to be applied to sedimentary basin geothermal power plants which use subsurface CO2. In this study, we present genGEO as open-source software, validate it with industry data, and compare its estimates to other geothermal techno-economic tools. We then apply genGEO to sedimentary basin geothermal resources and find that using CO2 as a subsurface heat extraction fluid compared to water decreases the cost of geothermal electricity across most geologic conditions that are representative of sedimentary basins. Using genGEO results and p50 geologic data, we produce supply curves for sedimentary basin geothermal power plants in the U.S., which suggests that there is present-day potential to profitably increase the capacity of geothermal power by ~10% using water as the subsurface heat extraction fluid. More capacity is available at lower cost when CO2 is used as the subsurface fluid, but realizing this capacity requires geologically storing between ~2 and ~7 MtCO2/MWe. But developing sedimentary basin resources in the short-term using subsurface water may not eliminate options for CO₂-based power plants in the long-term because the least-cost order of sedimentary basins is not the same for both CO2 and water. With sufficient geologic CO2 storage, developing sedimentary basins using CO2- and water-based power plants may be able to proceed in parallel.
The difference in views of various researchers about changes in the new drugs and clinical trial rules in India
Authors: Vishal Vennu  , Prem Saini  , Karan Singh
Published: January 2021

Some studies detailed the awareness and opinions of investigators and the members of the ethics committee about the previous rules. However, no study surveyed the differences in views of various researchers (such as investigators, co-investigators, members of the ethics committee (EC), research assistants, coordinators, associates, and managers) about the new drugs and clinical trial rules (NDCT Rules). The current study aimed to address this gap. In this online survey, a total of 106 various researchers were chosen randomly from different sources across India between July 2019 and September 2019. The various researchers classified into the following three groups based on their job role: investigators or co-investigators (n=24), members of the ethics committee (n=21), and other researchers (n=61). The difference in views of various researchers has shown in percentages. Out of 106 various researchers, most of the investigators or co-investigators significantly reported that the changes in reducing clinical trial timeline (87.5%, p <.0001) and equality are proper (87.5%, p = 0.028). However, the majority of other researchers significantly said that the severe adverse events report and compensation are adequate (78.6%, p = 0.005). Overall, the majority of members of the ethics committee significantly reported neutral about the changes in NDCT Rules (85.7%, p = 0.037). The results of this study indicate that there is a significant variation in the views of different researchers about the changes of NDCT Rules. Future study is required on the larger sample at a national level to generalize the views of various researchers on the topic.
Effects of silver nanoparticles on the anti-oxidant status and histological alterations in different organs in Indian mud crab Scylla Serrata
Authors: Deepa Rani S  , Sangeetha S  , Padmaja M  , Petchiammal R  , Shalini E
Published: January 2021

In medicine and many other fields, the use of silver nanoparticles is inevitable. The negative impacts of silver accumulated silver nanoparticles on the environment and organisms need to be taken into consideration. The studies on the effect of silver nanoparticles on bio-indicators such as marine invertebrates pave the way to regulate the usage of silver nanoparticles. In the present study, the effect of silver nanoparticles on the hepatopancreas of Indian mud crab, Scylla Serrata was studied. A 20ppm of silver nanoparticles was exposed to S. Serrata  for ten days period. The morphological changes, the biochemical markers from hepatopancreas, histological analysis for hepatopancreas, gills and reproductive organs were examined. On the 2nd day exposure of silver nanoparticles showed the increased value of anti-oxidants and no morphological changes. But the 10th-day exposure shows the significantly reduced level of biochemical markers in the hepatopancreas and morphological changes were observed. The apoptotic cells and necrotic cells were recorded in hepatopancreas. Moreover, the cell architecture of gill tissues and reproductive tissues were observed. The silver nanoparticles in the concentration of 20ppm caused significant changes in the hepatopancreas of S. Serrata for ten days of exposure. The mechanism of silver nanoparticles needs to be studied to understand and protect models from the nanoparticles.
Estimation of solifenacin and tamsulosin in rat plasma by LC-MS/MS: Application to a pharmacokinetic study
Authors: Chandramohan Kandasamy  , Kumar Mohan  , Alexandar S  , Sivaselvakumar Muthusamy
Published: January 2021

Effectiveness tests using a mixture of solifenacin and tamsulosin include the implementation of a research procedure for precise plasma evaluation of both drugs. For the direct estimation of solifenacin and tamsulosin, high quality liquid chromatography-tandem mass spectrometry in rat plasma (LC-MS / MS) methodology was designed. Extraction during solid phase technique used to obtain solifenacin, tamsulosin, and solifenacin D5, tamsulosin D4 (internal standards; IS) from 100 μL rat plasma. On the Thermo BDS Hypersil C8 (100 X 4.6 mm, 3.5 μm) column under isocratic elution with acetonitrile, chromatographic separation of analytes was done:10mM ammonium formate (80:20 v/v) 1 mL/min mobile phase flow rate. For both analytes and various IS, precursor ion and production transitions were tracked on a triple quadrupole mass spectrometer, controlled with positive ionization mode in the specific reaction monitoring. The model was employed for solifenacin over a range of concentrations of 0.100 to 30.014 ng/mL and for tamsulosin between 0.050 and 15.176 ng/mL. Mean recovery of solifenacin, tamsulosin, solifenacin D5 and tamsulosin D4 was 84.7%, 87.5%, 86.1% and 82.6%, was consistent at low, medium and high levels of QC. For both analytes, precision and accuracy were less than 15 percent at low, medium and high QCS with good performance levels of operation. Specific stabilities have been tested for all analytes, bench-top, wet extract, freeze-thaw and long-term stability. To help a pharmacokinetic analysis in Wistar rat, this analytical method for simultaneous estimated use of solifenacin and tamsulosin was applied for rat plasma.
Assessment of Quality of Life and Incidence of Depression in Post Stroke Patients
Authors: Aditya Dharman  , Chandrina Loungchot  , Ven Davis  , Mahshid Delavari  , Binai K Sankar  , Nandhini Swamy
Published: January 2021

Depression is a common illness worldwide. Social, psychological and biological factors can lead to depression. Chronic illness among the elderly is a significant reason affecting mental health. Often it is not diagnosed correctly. An observational study was conducted to assess the quality of life and the incidence of depression in post-stroke patients. Subjects were recruited to the study by investigations during ward/OP visits. The subjects were briefed about the study, and informed consent was obtained. Data were collected using various study tools and analyzed statistically by computing proportion for all qualitative data and mean, standard deviation, median, the interquartile range for quantitative data. A total of 50 subjects were enrolled in the study based on inclusion and exclusion criteria. Severe cognitive impairment was revealed in 14% of the patients. The burden of depression and severity was evaluated using Patient health questionnaire-9 and Hamilton depression scale, respectively. It was found that 22 subjects (44%) had moderate depression, while 2 (4%) had severe depression. The functionality of the subjects was measured and found that 18% of subjects were 'dependent' on their caregiver. SSQOL assessment showed the lowest score in the domains 'work & productivity' and 'energy". As much as treating the etiological factors of stroke, dealing with the mental aspect of stroke is necessary. Assessing and treating post-stroke depression is essential to reduce the morbidity and mortality of patients. Hence, early assessment and management of mental health after stroke is necessary to prevent a chance of developing another stroke.
Assessment of severity, quality of life and suicidal ideation in patients with depressive disorders
Authors: Imran Mansur M D  , Shreeharsha G  , Akshay C  , Ravi Chandra C V  , Binai K Sankar  , Smitha M
Published: January 2021

Depression is estimated to be the third leading cause of disability and about 350 million people suffer from depression worldwide. Various biological, social, economic, cultural factors and environmental factors contribute for depression. A total of 102 patients were enrolled in the study. Majority of the patients (64, 62.74%) included in the study were female. The mean age of the study subjects was found to be 20.4±11.88 years. The severity of symptoms in depressed patients evaluated using Hamilton Depression Rating Scale (HDRS) shows that 33.33% of the subjects were very severely depressed, followed by 29.41% of the subjects with moderate depression, 23.52 % with severe depression and 11.76% with mild depression. Quality of life was evaluated using WHOQOL BREF Scale in the study population. 51.96 % of subjects were having low quality of life (QoL) followed by 48% of subjects with medium QoL and 0.98% subjects with high QoL. Modified Scale for Suicidal Ideation (MSSI) was used to evaluate severity of suicidal ideation in study population. Interpretation of results shows that 74.50% were having low suicidal ideation and few subjects (8.82%) were found to have severe suicidal ideation. Depression negatively impacts individual’s functioning, work satisfaction, relationships, leisure, physical and mental health, sexual functioning, sleep patterns and overall sense of fulfilment and contentment with life. Severe form of depression can lead to suicidal risk, increased risk of morbidity, mortality, substantial imbalance on individual’s occupational potential,  significant physical and psychosocial impairment.
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
Authors: Kellaway Sophie G , Keane Peter , Edginton-White Benjamin , Regha Kakkad , Kennett Ella , Bonifer Constanze
Published: January 2021

Mutations of the haematopoietic master regulator RUNX1 are associated with acute myeloid leukaemia, familial platelet disorder and other haematological malignancies whose phenotypes and prognoses depend upon the class of the RUNX1 mutation. The biochemical behaviour of these oncoproteins and their ability to cause unique diseases has been well studied, but the genomic basis of their differential action is unknown. To address this question we compared integrated phenotypic, transcriptomic, and genomic data from cells expressing four types of RUNX1 oncoproteins in an inducible fashion during blood development from embryonic stem cells. We show that each class of mutant RUNX1 deregulates endogenous RUNX1 function by a different mechanism, leading to specific alterations in developmentally controlled transcription factor binding and chromatin programming. The result is distinct perturbations in the trajectories of gene regulatory network changes underlying blood cell development which are consistent with the nature of the final disease phenotype. The development of novel treatments for RUNX1-driven diseases will therefore require individual consideration.
"The war with pandemic world "LOCK DOWN LIFE
Authors: Baker Syed , Prasad M. N. Nagendra , Maheshan M.S. , Satish S. , Soni Vishal Dineshkumar
Published: January 2021

The present book compiles the life experiences of individuals from across the globe during the pandemic situation 2020. The year 2020, has been one of the most unforgettable year with the sudden emergence of novel corona and spreading across the globe like a wildfire claiming many lives and crippling the global economy.During this pandemic situation, the world activities were stand still due to lock down imposed across the globe.
HIGHER EDUCATION AND ONLINE TEACHING DURING THE PANDEMIC : EXPERIENCES OF A UNIVERSITY TEACHER
Authors: Rajapakse Champa
Published: January 2021

Pandemic is a disease prevalent all over the world. During a pandemic, restrictions on travel, disinfection of common places, social distancing and quarantining of the suspected are introduced influencing the normal lifestyles of people.
MY LEARNING AND LIFE EXPERIENCES OF “NEW NORMAL” DURING COVID-19 LOCKDOWN
Authors: Bhutia Sonam
Published: January 2021

Narrated my own short life experiences during this COVID-19 lockdown time from March-Sept 2020. I’m a working Assistant Professor at Government Pharmacy College, Rumtek Sajong located at far flown of North East Indian state-Sikkim, having geographical areas-7,096 Sq.km with population of 6.1 Lakhs according to Census 2011.
COVID: GOD’S GREAT BLESSINGS
Authors: Labajo Osmar Pogoy
Published: January 2021

Why are people worried and afraid of COVID? Why does the world consider this pandemic as a devastating crisis? Sad to say, the deep surface of its ultimate reality is not clearly seen by the reflective naked eyes by many.
QUARANTINE DAYS OF A COLLEGE STUDENT
Authors: Ravikumar Stuti
Published: January 2021

Twelfth of March, I was writing my internals. It was microbial biotechnology, I remember. The paper was really easy and I was acing it. I was almost finishing up my paper when the strangest thing happened.
LOCKDOWN AND NEW NORMALCY: FROM THE DIARY OF A RESEARCHER
Authors: man Archis
Published: January 2021

Three years after starting my Ph.D., focusing on the area of molecular endocrinology and toxicology at Banaras Hindu University, I would describe myself as a Mid-PhD research scholar. I'm seen as a senior by Masters Students, but as a relative newbie by my department's senior scholars. That is, of course, under normal circumstances, but from March 25, we have not been living under that old normal situation. Lockdown, I heard this word for the first time in my life on March 24, 2020.
IMPACT OF LOCKDOWN ON EDUCATION AND EMPLOYMENT
Authors: Shanbhogue Girish
Published: January 2021

Education is the process of gaining knowledge, inculcating the values, developing skills. Education is also the way to enhance innovative ideas, develop potentials and build the judgment and understanding..Education enables the people know their rights; it expands the vision and outlook to see the world. Education enables us to fight against violence, injustice and corruption.
ADAPTATION TO THE POST PANDEMIC WORLD: A BEHAVIOURAL STUDY
Authors: Borpujari Chinmoyee
Published: January 2021

The world today is facing a serious challenge of a global pandemic in the form of Covid-19. Since time immemorial Pandemic and epidemics have been triggering and causing mass destruction. An influenza pandemic is a worldwide epidemic of a new influenza virus somewhat distinct from present and previous human seasonal influenza viruses. Influenza viruses are continually evolving, allowing non-human influenza viruses to adapt such that they can quickly target people and propagate successfully from person to person.
DIGITALIZATION – A COMMUNICATIVE BRIDGE IN SCIENCE DURING PANDEMIC ERA
Authors: B.P. Harini
Published: January 2021

The pandemic situation has forced scientists to work from home and paused the trials and experiments reluctantly. It has led the scientists extremely stressed to have a continuity of the research in progress towards disentangling, especially those who are on the nib of graduation, job seekers, moving abroad for higher studies, and also lacunae in executing one's idea and interest to upgrade themselves.
Direito, desenvolvimento e liberdade: o direito tributário pode aprimorar esses conceitos?
Authors: Ribeiro Maria de Fátima , Pires Maciel Lucas
Published: January 2021

O presente artigo tem como objetivo estudar o desenvolvimento e a liberdade como um binômio fundamental para o século XXI e o papel do Estado para o atingimento dessas políticas. Para isso, evidenciou-se que o Brasil vem criando programas que evidenciam uma melhoria no desenvolvimento e na liberdade dos cidadãos, seja de forma individual ou na coletividade. Ademais, diferenciou-se crescimento econômico e desenvolvimento econômico, aduzindo que não tem a mesma base de aferição, sendo que o Direito ao Desenvolvimento, previsto no texto constitucional, no artigo 3º, como um dos objetivos da República Federativa do Brasil, requer mais que uma mera informação numérica, mas sim, uma efetiva mudança no índice de Desenvolvimento (IDH) da nação. A tributação, por isso, exerce papal fundamental, quando interfere na economia e faz política distributiva. Com isso, pode diminuir as desigualdades regionais, com a criação de áreas com tributação diferenciada, como por exemplo a Zona Franca de Manaus, que foi prorrogada até 2073, além de outras políticas como o Simples Nacional. Por isso, incrementar medidas político-fiscais é um mecanismo eficaz para que o Estado possa fomentar o atingimento do desenvolvimento atrelado a liberdade, com acréscimo nos resultados do Índice IRBES. Para elaboração do artigo utiliza-se o método dedutivo com pesquisas bibliográficas.
A brecha tecnológica como um dos obstáculos ao desenvolvimento
Authors: Silva Andre Ricardo Fonseca da
Published: January 2021

O presente artigo buscou examinar a brecha tecnológica como um dos obstáculos ao desenvolvimento. A abordagem foi feita com foco na análise da igualdade na distribuição de oportunidades de acesso às tecnologias da informação e da comunicação (TIC) no contexto dos indicadores utilizados para medir o acesso às TIC. A abordagem metodológica apontou-se como qualitativa, dedutiva com a técnica de revisão bibliográfica em material brasileiro e estrangeiro. Na pesquisa, constatou-se que a inclusão digital como objeto da redução das desigualdades sociais só se dá se as TIC forem apropriadas como instrumentos que propiciem aos usuários digitais uma melhoria real das suas vidas, transformando-os de indivíduos acríticos em cidadãos conscientes, reflexivos e críticos das informações colhidas nas TIC.
Coerência, integridade e decisão democrática: uma análise da necessária uniformização de jurisprudência no caso das decisões acerca do limite máximo consignável em contratos de crédito consignado realizados por servidores públicos do Estado do Rio Grande
Authors: Ribeiro Monique Ferrarese Stedile , Pasqual Cristina Stringari
Published: January 2021

O estudo analisa os diferentes conceitos do postulado da coerência, sua necessária utilização para a criação legislativa e para a decisão judicial, bem como sua íntima relação com os conceitos de unidade, sistema e integridade, utilizando, para isso, da pesquisa bibliográfica, de dados na internet e jurisprudencial como metodologia de estudo. Investigar-se-á também a relação entre integridade e coerência nas decisões judiciais e o regime democrático, sob a ótica da previsibilidade das decisões judiciais e da igualdade de tratamento aos litigantes e o incidente de assunção de competência como um dos instrumentos processuais aptos a conferir integridade e coerência às decisões de um mesmo Tribunal. Por fim, a investigação pretende criticar a ausência de uniformização jurisprudencial por parte dos Tribunal de Justiça do Rio Grande do Sul no caso dos contratos de crédito com descontos em folha de pagamento (contratos de crédito consignado) relativos aos servidores públicos do estado, que gera decisões em desconformidade com a coerência e a integridade da jurisprudência deste Tribunal.
História social: em busca de uma renovação na leitura do direito
Authors: Ribeiro Emmanoel Pedro
Published: January 2021

Este artigo pretende se inserir no processo de renovação dos estudos de História do Direito, iniciado ao longo dos anos 90 no Brasil, atualizando os seus pressupostos por meio de um diálogo mais estreito entre o jurista e o historiador. Conseqüentemente, proporcionar novas leituras do Direito brasileiro, de suas instituições e idéias, a partir da História Social inglesa.

Palavras-chave: Direito. História Social. História Social do Direito.
A água e o desenvolvimento sustentável
Authors: Ferreira de Andrade José
Published: January 2021

O objetivo deste artigo consiste na identificação dos alicerces da política nacional de recursos hídricos de garantir a quantidade dos recursos e sua qualidade, de promover objetivos de desenvolvimento sustentável no sentido genérico usado pela Comissão Mundial sobre Meio Ambiente e Desenvolvimento. Visa estabelecer padrões aptos a garantirem a saúde pública, o bem estar da população e a possibilidade de se praticar o uso da pesca, objeto de pesquisa de iniciação científica do Curso de Direito.

Palavras-chave: Água. Rios. Pesca. Desenvolvimento sustentável.
Assistência jurídica: instrumento da política nacional das relações de consumo
Authors: Holanda de Vasconcelos Brandão Fernanda
Published: January 2021

Considerando que o consumidor encaixa-se perfeitamente no art. 5.º, LXXIV, da Constituição Federal, que estabelece o dever do Estado na prestação de assistência jurídica integral e gratuita aos que comprovarem a insuficiência de recursos, o presente artigo se propõe a analisar a assistência jurídica como instrumento da política nacional das relações de consumo. Identificar-se-á o seu objetivo no âmbito do direito do consumidor, discutindo os princípios basilares dessa política e a sua importância para a defesa do consumidor.

 

Palavras-chave: Assistência jurídica. Instrumento. Consumidor. Acesso à justiça. Defesa
A ética da igualdade: em busca de fundamentos universalizantes
Authors: Corrêa Darcísio , Damião Corrêa Tobias
Published: January 2021

Este artigo analisa a igualdade sob o ponto de vista da ética e da cidadania, buscando fundamentos universalizantes que lhe deem sustentação. A ética vem relacionada com o pressuposto da finitude humana e a busca de transcendência. Procura-se aprofundar as categorias da liberdade e da igualdade, no intuito de superar sua concepção jurídica meramente formal. Busca-se uma nova dimensão da cidadania contemporânea, tendo como fundamento uma ética de caráter horizontal e universalizante, capaz de imprimir à trajetória humana novas formas e espaços de transcendência.

Palavras-chave: Ética. Cidadania e direitos humanos. Finitude humana. Liberdade e igualdade.
A liberdade econômica como pressuposto para o desenvolvimento nacional
Authors: De Freitas Teixeira Osvaldo , Pereira da Cunha Belinda
Published: January 2021

Trata-se de ensaio que discute a liberdade como forma elementar do homem a partir de textos clássicose, posteriormente, a conceituação de constituição econômica e como a liberdade e economia, juntas, poderão ser fundamentais para o desenvolvimento nacional fundamentada no direito ao desenvolvimento socioeconômico, justo e igualitário.Palavras-chave: Liberdade. Constituição econômica. Desenvolvimento.
Concorrência e desenvolvimento: contributos da extrafiscalidade da tributação
Authors: Basso Ana Paula , C. Santos Rodrigo Lucas
Published: January 2021

Cada vez mais a concorrência no mercado internacional define os rumos do desenvolvimento dos países. Nesse contexto, tem- se intensificado a importância do uso da tributação como meio de intervenção do Estado na economia. A extrafiscalidade é uma das formas por meio da qual o Direito Tributário pode atuar para potencializar a competitividade das empresas nacionais no mundo globalizado e é isso que este estudo pretende analisar.Palavras-chave: Tributação. Extrafiscalidade. Concorrência.
O CDC e a lei nº 12.414, de 09 de junho de 2011: reflexões sobre a formação e consulta a banco de dados, adimplemento e histórico de créditos de consumidores considerados “bons pagadores”
Authors: De Vasconcelos Fernando Antônio , Paiva Marinho de Sousa Rosilene
Published: January 2021

Apresenta-se neste artigo uma reflexão sobre a Lei nº 12.414, de 9 de junho de 2011, que disciplina a formação e consulta a banco de dados com informações de adimplemento, de pessoas naturais ou jurídicas, para formação de histórico de créditos. Comparam-se os efeitos desta lei ao que dispõe o Código de Defesa do Consumidor, procurando compreender doutrinária e documentalmente um dos direitos fundamentais previstos na Constituição Federal, que é o direito à informação. Busca, ainda, abordar o assunto sob a perspectiva de possíveis práticas abusivas com relação à publicidade.

Palavras-chave: Lei. Cadastro. Consumidor. Banco de dados. Acesso à informação.
A promoção de habitações e a construção na Espanha: novos incentivos fiscais no imposto sobre o valor adicionado
Authors: Patón García Gemma
Published: January 2021

Entre outras medidas de caráter econômico, o legislador espanhol tem aprovado diversas medidas fiscais em matéria de operações relacionadas à habitação e à construção realizadas pelos sujeitos passivos do IVA. Ainda que recentemente se tenha tido aumento nos percentuais do IVA, não obstante, introduziram-se incentivos fiscais para os promotores do IVA para dinamizar o mercado da habitação. Este artigo faz um percurso no conjunto de medidas tomadas para enfrentar a crise econômica.

Palavras-chave: Habitação. Construções. Incentivos fiscais. IVA.
A questão do monopólio dos correios e a ADPF 46-7
Authors: Nogueira de Queiroz Julian
Published: January 2021

Dentre as formas de intervenção do Estado no domínio econômico destaca-se a intervenção por absorção, que consiste na formação de monopólios em prol de determinadas atividades de atribuição exclusiva da União. Neste cenário, discute-se se o monopólio criado na égide da Constituição passada para o serviço postal e o correio aéreo nacional, desempenhado pela Empresa Brasileira de Correios e Telégrafos, fora, de fato, recepcionado pela legislação constitucional ora vigente, questão que foi posta à análise do Supremo Tribunal Federal por meio da ADPF 46-7 cujos contornos envolvem, dentre outros aspectos, o enquadramento do serviço postal como serviço público, bem como o enquadramento constitucional das normas que atinem à matéria.

Palavras-chave: Monopólio. Serviço Postal. Correios. Jurisdição Constitucional.
A EMPRESA INDIVIDUAL DE RESPONSABILIDADE LIMITADA (EIRELI – LEI 12.441/2011)
Authors: Moscatini Áurea
Published: January 2021

O presente estudo trata das principais características e aspectos controvertidos da Lei que instituiu a EIRELI (Lei 12.441/ 2011). Tal lei, nova em nosso ordenamento jurídico, busca uma alternativa para que a atividade empresarial possa ser exercida por uma só pessoa, com responsabilidade limitada, ou seja, sem que haja invasão de seu patrimônio pessoal em caso de a empresa contrair dívidas. Dessa forma, o presente trabalho busca demonstrar qual o objetivo da referida Lei.