bluuebunny/crossref_metadata_2025 huggingface dataset:
EXPERIMENTAL VERIFICATION OF CONSTRUCTIVE SOLUTION OF A NEW TYPE FRAMEWORK
Authors: Shmukler V.S. , Lugchenko O.I. , Nazhem A.H.
Published: May 2021

Experimental verification is an integral part of the study for both new designs and new materials and technologies. To assess the features of deformation of the lightweight frame, a series of tests using the method of hydrostatic loading, developed at the Department of Building Structures O.M. Beketov national university of urban economy in Kharkiv. A fragment of a monolithic reinforced concrete frame with a floor slab with a span of 6.0 m and a thickness of 500 mm (thickness of both claddings 100 mm, liner thickness 300 mm) was selected as the object of study. The purpose of the study is to assess the deformability of lightweight frame structures. The tests were implemented under the action of short-term and long-term evenly distributed loads, and were carried out in accordance with the method of hydraulic tests of plates and shells on the basis of the requirements of DSTU B B.2.6-7: 95. For research the research method based on hydrostatic loading of object when loading is set by weight of water is used, and its size is regulated by height of a water column. To carry out the described test procedure on the mezzanine floor of the seventh floor was assembled inventory pool of formwork panels with dimensions in terms of 5.2x2.8 m and a board height of 1.15 m. To register the measured displacements, sensors are supplied to the object under study, which allow to establish the characteristics of the stress-strain state of the object of study. Use of this method, in comparison with other existing, allows to define durability and deformability of various full-scale designs at short-term and long loading without their destruction and a stop of production process. The obtained results of field testing of a fragment of a lightweight frame indicate that the nature of the deformation of the floor under load correlates with the results of similar studies that have been repeatedly conducted for the frames of buildings with load-bearing elements with a continuous cross section.
INTERDISCIPLINARY INTERACTION OF DESIGN AND ARCHITECTURE
Authors: Vergunova N. , Vergunov S. , Levadniy O.
Published: May 2021

The synthesis of scientific knowledge obtained within individual disciplines became one of the leading trends in science in the latter half of the 20th century. Together with the existing disciplinary organization and the structuring of science according to the respective specializations, interdisciplinary methodology is being actively developed, problem and project approaches to research are increasingly being applied, the paradigm of integrity is being established. Such processes have also affected design, both theoretical and practical aspects of work. Considering the interdisciplinary interaction of design with other art forms, architecture appears to be most appropriate, given the commonality of design and architectural design dating back to the mid-20th century. Many architects design objects and placing them in their architectural constructions; and designers work with architectural projects, creating a «shell» for their design objects. There is a semantic organization in these processes, the study of which is relevant in view of the emerging paradigm of integrity in science.
The aim of research reveals the interdisciplinary interaction between design and architecture, and represents the relevant projects of designers and architects. The results can be used to broaden the understanding of interdisciplinary methodology regarding to its emergence and formation in design and architecture, as well as their current project results.
The scientific paper describes some of the professional patterns inherent in design and architecture that unite these arts in filling the object-spatial environment. Common meaning organization of design and architectural subject culture in comparison with samples of «pure» art is also noted, the direct inclusion of these objects in the life canvas of each individual is emphasized. The interdisciplinary interaction of design and architecture contributes to their mutual filling. For design work, the main priority of interdisciplinarity is in studying the architectural heritage that far exceeds the design culture over time. For architectural activity it is possible to expand its professional boundaries by mastering the specifics of design methodology, as well as to optimize the project process in creating a coherent and harmonious structure of building.
Interdisciplinary interaction is evident in project activities of modern designers and architects. The projects of American designer Karim Rashid, who works on both: the industrial design projects and objects for the architectural environment, are of particular interest. Architectural bureau «Zaha Hadid Architects», once headed by the Iraqi-British architect and designer of Arab origin Zaha Hadid, also conducts interdisciplinary project activity, touching both design and architecture. The projects of Gerrit Ritveld, designed more than a hundred years ago, confirm the extent of interdisciplinary links in design, architecture and art, reflecting the objectivity of these processes.
CONTENT SPECIFICATION OF THE CONCEPT "SPORTS AND LEISURE COMPLEX" FOR RESEARCHING URBAN ENVIRONMENT DEVELOPMENT
Authors: Dreval І. , Baibak D.
Published: May 2021

Background: The expediency of the study lies in the need of the society to address the issue of improving the level of physical activity and health of the Ukrainians. To do this, it is necessary to rely on scientifically grounded ideas about the essence of sports and leisure complexes that meet the needs of the population. Therefore, the purpose of this work is to specify the meaning of the concept of "sports and leisure complex".
Methods: To achieve the goal of the study, the following tasks are consistently solved: analysis of scientific works that cover various aspects of the formation and development of sports and leisure objects; exposure of the essence of the life processes that are localized in the structure of the studied objects; analysis of the conceptual and terminological apparatus used in the research of modern sports and leisure activities in related scientific domains; specification of the concept of "sports and leisure complex" in the architectural and town-planning sphere.
Results: Analysis of the scientific literature and practical experience on the research topic proves that current trends in the society and sports development, as well as prospects for convergence of amateur and professional approach to sport necessitate the development of new approaches to architectural and urban organization of sports and leisure complexes.
Conclusions: Sports and leisure complex is a special material and spatial formation of the urban environment, which meets the needs of citizens in realization of the creative potential and self-actualization of a person at leisure in the form of physical loading as well as recovery of physical, spiritual and intellectual, energy, psycho-emotional resources. Different forms of functional and spatial organization of sports and leisure complexes are determined by the dominant type of physical activity, the needs of users, town-planning conditions, the author's idea. These objects provide not only sports and recreation activities, but also informal social communication, which contributes to strengthening of urban communities.
ANALYSIS OF ANALYTICAL MODELS AND THE DEPENDENCES REALIZED BY THEM FOR DEFINITION OF MECHANICAL CHARACTERISTICS OF COMPOSITE FILLERS
Authors: Kondratiev A.
Published: May 2021

The analysis of the accuracy of analytical models and the mechanical properties they implement is carried out for various types of composite aggregates of sandwich structures. The accuracy assessment of approximate analytical dependencies of the mechanical characteristics of the composite honeycomb core is given. The applicability of analytical dependencies at the initial stages of the design of cellular structures is established. The accuracy of the results of a numerical experiment is noted. This is due to the approximate nature of standard test methods. Both for the elastic modulus and for the shear moduli, their values obtained on the basis of information technologies of finite element analysis exceed their corresponding values determined by analytical dependencies. This excess over the corresponding analytical values for the shear moduli is close to a constant value for various reinforcement angles and does not exceed 1.14. For the elastic modulus of the first kind, the excess varies from 1.03 to 1.8 for various angles of cell reinforcement. The analytical dependences of the reduced mechanical characteristics of the tubular aggregate are obtained. The idea of the method for determining the mechanical characteristics of a tubular filler is to fulfill the requirement of equality of the relative axial and shear deformations of a conventional continuous type element and a real one, selected within one tube, taking into account only its material. The conclusion is drawn that the mechanical characteristics of the tubular aggregate, determined by the analytical model, to different degrees differ from the corresponding characteristics obtained on the basis of information technology of finite element analysis. Moreover, the difference in the elastic moduli of the first kind is much smaller than in the shear moduli. The reasons for these discrepancies are analyzed. It is justified and recommended to use constant correction factors for the analytical values of the reduced mechanical characteristics of the tubular aggregate, allowing their further use in the calculation of plate and shell sandwich structures.
First Description of Various Bacteria Resistant to Heavy Metals and Antibiotics Isolated from Polluted Sites in Tunisia
Authors: MILOUD SAMAR BEN , DZIRI OLFA , FERJANI SANA , ALI MUNTASIR MD , MYSARA MOHAMED , BOUTIBA ILHEM , HOUDT ROB VAN , CHOUCHANI CHEDLY
Published: May 2021

Environmental bacteria belonging to various families were isolated from polluted water collected from ten different sites in Tunisia. Sites were chosen near industrial and urban areas known for their high degree of pollution. The aim of this study was to investigate cross-resistance between heavy metals (HM), i.e., silver, mercury and copper (Ag, Hg, and Cu), and antibiotics. In an initial screening, 80 isolates were selected on ampicillin, and 39 isolates, retained for further analysis, could grow on a Tris-buffered mineral medium with gluconate as carbon source. Isolates were identified based on their 16S rRNA gene sequence. Results showed the prevalence of antibiotic resistance genes, especially all isolates harbored the bla
TEM gene. Some of them (15.38%) harbored bla
SHV. Moreover, several were even ESBLs and MBLs-producers, which can threaten the human health. On the other hand, 92.30%, 56.41%, and 51.28% of the isolates harbored the heavy metals resistance genes silE, cusA, and merA, respectively. These genes confer resistance to silver, copper, and mercury. A cross-resistance between antibiotics and heavy metals was detected in 97.43% of our isolates.
Educação financeira: um plano para aplicação nos anos finais do ensino fundamental
Authors: Brunhera Diandra Carla Uncini
Published: May 2021

Resumo: Este artigo busca propor um plano de aula sobre matemática financeira para alunos dos anos finais do ensino fundamental a fim de enfatizar a temática de educação financeira. A pesquisa adota uma abordagem qualitativa, e a pesquisa bibliográfica como técnica documental, utilizando as funções financeiras da planilha eletrônica do Excel como recurso complementar ao processo de ensino aprendizagem. Acredita-se que o uso de recursos tecnológicos em sala possa contribuir com o desenvolvimento de um aluno motivado e ativo, além da relevante contribuição social e econômica ao fomentar a formação de uma geração comprometida. Sugere-se aprofundar o assunto inserindo novos conceitos para a análise e, incentivando o planejamento antes da tomada de decisão, visando o bom desempenho do orçamento familiar.Palavras-chave: Educação Financeira; Excel; Tecnologias. Financial education: a plan for application in the final years of educationAbstract: This article seeks to propose a lesson plan on financial mathematics for students in the final years of elementary school in order to emphasize the theme of financial education. The research adopts a qualitative approach, and bibliographic research as a documentary technique, using the financial functions of the Excel spreadsheet as a complementary resource to the teaching-learning process. It is believed that the use of technological resources in the classroom can contribute to the development of a motivated and active student, in addition to the relevant social and economic contribution in fostering the formation of a committed generation. It is suggested to deepen the subject by inserting new concepts for analysis and, encouraging planning before decision making, aiming at the good performance of the family budget.Keywords: Financial Education; Excel; Technologies.
Armas químicas e o desenvolvimento científico: o uso do júri simulado como estratégia didática para o ensino de química
Authors: Alvaro Marcela Vitor , Borges Marcia Narcizo , Florêncio Antonio da Silva
Published: May 2021

Resumo: Partindo da premissa de que os alunos aprendem melhor quando o desenvolvimento científico e tecnológico é historicizado, realizou-se um projeto de Ensino de Química com estudantes do 1º período do Ensino Médio Integrado ao Curso Técnico de Química tendo armas químicas como tema sociocientífico. O projeto utilizou o júri simulado como principal estratégia de ensino e no caso, julgaram a responsabilidade da Alemanha quanto à produção e uso de armas químicas durante a II Guerra Mundial. A avaliação do projeto foi feita de modo processual através da coleta e sistematização de dados obtidos ao longo das aulas. A Análise de Conteúdo dos argumentos utilizados pelos estudantes evidencia que a estratégia do júri simulado contribuiu para que eles construíssem um conhecimento químico crítico, compreendendo que o desenvolvimento científico e tecnológico é resultado de uma atividade essencialmente humana, e que, portanto, se dá sob interferência política e econômica.Palavras-chave: Armas Químicas; Aspectos históricos; Júri Simulado. Chemical weapons and scientific development: the use of the simulated jury as a didactic strategy in the teaching of chemistryAbstract: Starting from the premise that students learn better when scientific and technological development is historicized, a Chemistry teaching project was carried out with students from the 1st period of High School Integrated with the Technical Course in Chemistry having chemical weapons as a social scientific theme. The project used the simulated jury as the main teaching strategy. In this case, they judged Germany's responsibility for the production and use of chemical weapons during the II World War. The evaluation of the project, carried out in a procedural way through the collection and systematization of the data obtained during the classes. The Content Analysis of the arguments used by the students shows that the strategy of the simulated jury contributed to them building a critical chemical knowledge, understanding that the scientific and technological development is the result of an essentially human activity, which therefore takes place under political and economical interference.Keywords: Chemical Weapons; Historical aspects; Simulated Jury.
Tendências e perspectivas da formação continuada de professores da área de ciências da natureza e suas tecnologias: um panorama das pesquisas brasileiras no período de 1997 a 2018
Authors: Piotrowski Solange Maria , Güllich Roque Ismael da Costa
Published: May 2021

Resumo: Neste estudo, realizamos um levantamento bibliográfico das teses e dissertações presentes no Instituto Brasileiro de Informação em Ciência e Tecnologia, referentes à formação continuada de professores de Ciências da Natureza e suas Tecnologias (CNT). Em nossa investigação, analisamos as concepções de ensino/formação e as principais temáticas que permeiam estas pesquisas desenvolvidas em nosso país, no período de 1997 a 2018. A partir da análise temática do conteúdo, categorizamos a priori as concepções de ensino/formação, sendo que as temáticas foram construídas a posteriori. A partir dos referenciais da área, discutimos as concepções e as temáticas identificadas, destacando a formação continuada pela via compartilhada, na perspectiva da investigação-formação-ação, como modelo possível de desenvolver a concepção emancipatória na área de CNT.Palavras-chave: Formação continuada; Concepções de ensino; Investigação-ação; Reflexão crítica. Trends and perspectives of continuing formation for teachers in the nature sciences area and its technologies: a panorama of brazilian research in the period 1997 to 2018 Abstract: In this study, we carried out a bibliographic survey of the theses and dissertations present at the Instituto Brasileiro de Informação em Ciência e Tecnologia, referring to the continuing education of teachers of Natural Sciences and their Technologies (NST). In our investigation, we analyzed the teaching/formation conceptions and the main themes that permeate these researches developed in our country, from 1997 to 2018. From the thematic analysis of the content, we categorize the teaching/formation conceptions as priorities, and the themes were built later. Based on the references in the area, we discuss the conceptions and themes identified, highlighting continuing education through the shared path, from the perspective of research-formation-action, as a possible model to develop the emancipatory conception in the NST area.Keywords: Continuing education; Conceptions of teaching; Action research; Critical reflection.
Análise da prática pedagógica e o desenvolvimento da argumentação em aulas de física
Authors: Borges Juliana Rosa Alves , Ustra Sandro Rogério Vargas
Published: May 2021

Resumo: A habilidade de argumentar é essencial ao cidadão contemporâneo. Apesar de trabalhada de forma pouco criteriosa em sala de aula, apresenta papel central no processo de aprendizagem em Física. Destarte, nosso propósito principal neste estudo foi apurar aspectos relevantes no desenvolvimento da argumentação no ambiente do Ensino por Investigação em aulas de Física. A pesquisa de natureza qualitativa utilizou princípios da pesquisa-ação tendo como alvo uma melhor qualidade para a interação professor/aluno. As atividades didáticas foram desenvolvidas em grupos pelos estudantes e o processo de investigação contou com a monitoria docente. Os dados foram coletados no diário da prática pedagógica, utilizando-se para sua compreensão elementos da Análise de Conteúdo. Destacamos a consolidação do protagonismo estudantil e da qualidade argumentativa nesse contexto do Ensino por Investigação.Palavras-chave: Argumentação; Ensino de Física; Ensino por Investigação. Analysis of pedagogical practice and the development of argumentation in physics classes Abstract: The ability to debate is an essential quality for the contemporary citizen. Although worked in a non-judicious way in the classroom, it plays a central role in the Physics learning process. Our main purpose in this research was to investigate the relevant aspects in argumentation development in the Teaching per Inquiry environment in physics classes. In this qualitative research, we used research-action principles having as purpose a better teacher/student interaction. There were applied didactic activities in the students group and the investigation process included monitoring by the teacher. Data were collected in the pedagogical practice diary, using elements of Content Analysis for their understanding. We highlight the consolidation of the students’protagonism and of the argumentative quality in this context on Teaching per Inquiry. Keywords: Argumentation; Physics teaching; Teaching per Inquiry.
The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality
Authors: Issaian Aaron , Hay Ariel , Dzieciatkowska Monika , Roberti Domenico , Perrotta Silverio , Darula Zsuzsanna , Redzic Jasmina , Busch Micheal P. , Page Grier P. , Rogers Stephen C. , Doctor Allan , Hansen Kirk C. , Eisenmesser Elan Z. , Zimring James C. , D’Alessandro Angelo
Published: May 2021

Band 3 (anion exchanger 1; AE1) is the most abundant membrane protein in red blood cells, which in turn are the most abundant cells in the human body. A compelling model posits that, at high oxygen saturation, the N-terminal cytosolic domain of AE1 binds to and inhibits glycolytic enzymes, thus diverting metabolic fluxes to the pentose phosphate pathway to generate reducing equivalents. Dysfunction of this mechanism occurs during red blood cell aging or storage under blood bank conditions, suggesting a role for AE1 in the regulation of the quality of stored blood and efficacy of transfusion, a life-saving intervention for millions of recipients worldwide. Here we leveraged two murine models carrying genetic ablations of AE1 to provide mechanistic evidence of the role of this protein in the regulation of erythrocyte metabolism and storage quality. Metabolic observations in mice recapitulated those in a human subject lacking expression of AE11-11 (band 3 Neapolis), while common polymorphisms in the region coding for AE11-56 correlate with increased susceptibility to osmotic hemolysis in healthy blood donors. Through thermal proteome profiling and crosslinking proteomics, we provide a map of the red blood cell interactome, with a focus on AE11-56 and validate recombinant AE1 interactions with glyceraldehyde 3-phosphate dehydrogenase. As a proof-of-principle and to provide further mechanistic evidence of the role of AE1 in the regulation of redox homeo stasis of stored red blood cells, we show that incubation with a cell-penetrating AE11-56 peptide can rescue the metabolic defect in glutathione recycling and boost post-transfusion recovery of stored red blood cells from healthy human donors and genetically ablated mice.
Nitrogen-siliceous thermal waters in the therapy of patients with psoriasis (On the 155th anniversary of the Annenskie Vody sanatorium)
Authors:   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai, Nekipelova A.V.
Published: May 2021

In 2021 the sanatorium "Annenskie Vody" will be 155 years old. This is the oldest balneological institution in the Khabarovsk Territory, a Far Eastern health resort that helps restore health to the population using natural factors. Annenskie Vody sanatorium receives more than three thousand patients annually, and almost 7 % of the patients are patients with skin diseases. The main healing factor in the Annenskie Vody sanatorium is mineral water. The spring water is thermal (t 52 ºC), slightly mineralized (0.2–0.3 g/l), hydrocarbonate-sulphate-sodium, alkaline, with a high content of silicic acid. There were 560 psoriasis patients aged from 18 to 70 years under observation. Of these, 360 are women and 200 are men. To assess the severity and effectiveness of the therapy in patients with psoriasis, the PASI index was used, which decreased by 4 times during therapy. Biochemical parameters improved under the influence of AKTW. The effectiveness of therapy increased with the use of complex methods of exposure (mud therapy, physiotherapy).
Mirroring Misogyny in Hell Choson: Megalia, Womad, and Korea’s Feminism in the Age of Digital Populism
Authors: Kim Youngmi
Published: May 2021

In recent years digital populism has emerged in South Korea as a new type of
political behavior, marked by the political use of the internet as both a form of
political participation and an instrument of mobilization. Technological advances
and the diffusion of social media have enabled social polarization, rooted in
post-Asian Financial Crisis neoliberal policies, to take on a new, more intense,
emotional, and radical dimension in the virtual environment. The article examines
a case study of an online conflict over the issue of misogyny in 2015–2016 to reflect
on how a group of online feminists, namely Megalia and its splinter off-shoot
Womad, have used the new media as a terrain for challenging the pervasive
misogyny in Korean society. As the article focuses on the online activists’ strategy
of mirroring, it highlights how the experiences and worldviews of members of
both groups are rooted in identity politics and argues that the understanding
of this online conflict should be embedded in similar global and national socioeconomic processes. Lastly, the case study also identifies some of the challenges
that online feminism has encountered in Korea.
Islands in Korean Movies: On the Mobility/Immobility of Isolation
Authors: Shin Inseop
Published: May 2021

Developments in mobility have brought about a phase in which people across the planet are able to partake in movement. Inhabitants of islands are no exception. The purpose of this study is to explore ways to analyze the problem of (im)mobility depicted in cinema through the example of the film My Dream Class (2018) that represents the common sentiment that Koreans have about islands in the twentyfirst century. With a focus on illuminating issues for the understanding of the island “here and now,” this study will bring forth how our perception of islands is important to the cultural discourse in Korea.
Phenotype and function of macrophage polarization in monocrotaline-induced pulmonary arterial hypertension rat model
Authors: Fan Yong , Hao Yanjie , Gao Dai , Gao Lan , Li Guangtao , Zhang Zhuoli
Published: May 2021

Pulmonary arterial hypertension (PAH) is a fatal disease characterized by vascular remodeling and chronic inflammation. Macrophages are the key orchestrators of inflammatory and repair responses, and have been demonstrated to be vital in the pathogenesis of PAH. However, specific phenotype of macrophage polarization (M1 & M2 macrophage) in the development of PAH and the underlying mechanisms how they work are still largely unclear. A rat model of monocrotaline (MCT) induced PAH was used. Hemodynamic analysis and histopathological experiments were conducted at day 3, 7, 14, 21 and 28, respectively. In PAH rat lung tissue, confocal microscopic images showed that CD68+NOS2+ M1-like macrophages were remarkably infiltrated on early stage, but dramatically decreased in mid-late stage. Meanwhile, CD68+CD206+ M2-like macrophages in lung tissue accumulated gradually since day 7 to day 28, and the relative ratio of M2/M1 macrophage increased over time. Results detected by western blot and immunohistochemistry were consistent. Further vitro functional studies revealed the possible mechanism involved in this pathophysiological process. By using Transwell co-culture system, it was found that M1 macrophages induced endothelial cell apoptosis, while M2 macrophages significantly promoted proliferation of both endothelial cell and smooth muscle cell. These data preliminarily demonstrated a temporal dynamic change of macrophage M1/M2 polarization status in the development of experimental PAH. M1 macrophages participated in the initial stage of inflammation by accelerating apoptosis of endothelial cell, while M2 macrophages predominated in the reparative stage of inflammation and the followed stage of aberrant tissue remodeling.
NOVEL NON-AQUEOUS ELECTROLYTES BASED ON COORDINATION BORON COMPOUNDS
Authors: Diamant Viktor
Published: May 2021

The review provides a classification of electrolytes for modern chemical power sources, supercapacitors, sodium and lithium-ion batteries depending on changes in the physicochemical properties of salts and the products of their interaction with the solvent. A comparative analysis of physicochemical properties of salts depending on the structure of the cation and anion, and the influence of these properties on the properties of final solutions of electrolytes on the example of different classes of ionic liquids and chelatoborates of alkali metals and ammonium was conducted. The dependence of the physicochemical properties of electrolytes (solubility, electrical conductivity of solutions and the range of potentials of electrochemical stability) on the nature of the chelate ligand, electron donor and electroacceptor substituents in the bis (chelate) borate anion is analyzed. The electrical conductivity of salt solutions and ranges of potentials of electrochemical stability of the corresponding electrolytes containing other anions and used for a long time in chemical current sources are carried out. The advantages and disadvantages of using liquid electrolytes compared to solid and polymer electrolytes in terms of similarity of their structures have been detected. It is shown that the nature of the chelate ligand, electro-donor and electro-acceptor substituents in the bis (chelato) borate anion is an important factor in regulating the interaction with aprotic dipolar solvents. Mixed salts with two different chelate ligands typically combine the best characteristics of the corresponding monochelate compounds, but the methods for their preparation and purification are technologically significantly more complex compared to monochelate compounds. The analysis of the mechanism of formation of a protective film on a surface of electrode materials, dependence of potential on its formation and on the chemical nature of ligands is made. It is noted that bis (chelato) borate salts are more environmentally friendly compared to fluorine-containing complex salts. Emphasis is placed on the physicochemical properties of solutions of the most promising chelatoborate salts for use in lithium and sodium ion batteries, supercapacitors and electrolytic capacitors, and it is shown that bis (oxalate) borates and bis (salicylate gold) borates occupy ) borates in terms of electrical conductivity, solubility and potential range of electrochemical stability.
Hemostasis and Cognitive Brain: 5P-Medicine and Chronotherapy of Arterial Hypertension
Authors: Pyatin V. , Maslova O. , Romanchuk N. , Bulgakova S. , Volobuev A.
Published: May 2021

Neurophysiological and cardioneurological polyfunctional studies of the brain-heart system in the rehabilitation of neurological patients using high medical technologies will help answer many questions related to the optimization of patient management in combined cerebral and cardiac pathology in the recovery period. Late chronotype and later sleep patterns are associated with greater morbidity, including higher rates of metabolic dysfunction and cardiovascular disease (CVD). Numerous studies have been adjusted for age, sex, ethnicity, smoking, body mass index, sleep duration, socioeconomic status, and comorbidities. Age groups, especially being a defined evening type, were significantly associated with a higher prevalence of all comorbidities. The results suggest increased mortality in evening types and increased levels of cardiometabolic risk factors in these groups. The risk of mortality in evening types may be due to behavioral, psychological, and physiological risk factors, many of which may be associated with chronic inconsistencies between internal physiological timelines and external working and social activities. Multilevel and interneural interactions are a leading factor in the formation of higher mental functions and self-development of the personality. Circadian homeostasis regulates and synchronizes the functions of adult stem cells and their changes during aging, as well as modulates their external and internal mechanisms. The circadian clock synchronizes cellular physiology with daily environmental changes and can both positively and negatively affect physiological processes. Circadian onset of CVD often shows a change in the time of day and is associated with the molecular clock system. Acute myocardial infarction or ventricular arrhythmia (ventricular tachycardia) occurs mainly early in the morning. Numerous biochemical and physiological parameters show a circadian rhythm that may explain daily variations in cardiovascular events. These include fluctuations in blood pressure, autonomic nervous system and renin-angiotensin axis activity, blood clotting cascade, vascular tone and intracellular metabolism of cardiomyocytes. New insights into the molecular and cellular pathways by which cardiovascular events occur in a daily oscillatory pattern will help create a new therapeutic approach to CVD treatment. Research continues on the updated modern problem of circadian brain and heart neurocommunications during the period of electromagnetic and information load/overload, the influence of new genetics and epigenetics, changes in hemostasis and homeostasis, the formation of new immunity and microbiota, in conjunction with modern neurobite and neuromarketing, with 5P Medicine and 5G technologies of neurocommunication.
Results of Assessing the Level of Competence of Dentists on the Complex Treatment and Rehabilitation of Patients With Periodontal Tissue Diseases
Authors: Imanalieva A. , Kuttubaeva K. , Abaskanova P. , Tursunaliev O. , Bakiev B. , Moldobaev B.
Published: May 2021

Inflammatory periodontal diseases are a serious medical and social problem and the effectiveness of the provision of medical and preventive care to patients is determined by a full diagnosis of the disease, a competent selection of methods of treatment and rehabilitation, a reasonable combination of therapeutic, surgical, orthopedic and physiotherapeutic measures. Complexity and an individual approach are the main conditions for successful treatment, which directly depends on the level of professional knowledge of dentists. The aim of the study was to analyze the level of competence of dentists on the methods of complex treatment and rehabilitation of patients with inflammatory diseases of periodontal tissues in Bishkek. Questioning of respondents — 87, statistical. For the study, a questionnaire “Dentist’s Awareness of Modern Principles of Diagnosis and Treatment of Periodontal Tissues” was developed, containing 14 questions that reveal the ideas of dentists-therapists about modern principles of classification, diagnosis and treatment of inflammatory diseases of periodontal tissues. According to the results of the questionnaire, low competence in treatment issues was revealed: 88.5% of the training at the advanced training courses took place on average 11.5±2.9 years ago; 58.6% (51/87) of respondents did not have a qualification category; Assessment of knowledge of the main stages of complex treatment — 66.7% did not give an answer, and 33.3% (29/87) noted various options for treatment stages and their combination. Evaluation of AMP use: 57.5% indicated metronidazole, 55.2% β-lactam antibiotics — amoxicillin and amoxicillin, then — lincomycin, erythromycin and chloramphenicol. Inappropriately prescribed: chloramphenicol, the frequency of administration of which should be 4 times a day; erythromycin — 3 to 4 times a day; lincomycin — 3-4 times a day, amoxicillin in 76.4% of cases, it was also prescribed irrationally, the recommended one — 3 times a day. In 50.6% of cases, analgesics and fluoride and calcium preparations were correctly used for symptomatic therapy, 49.4% of cases indicated the need to remove dental plaque.
Concreción de políticas educativas.
Authors: Villalaz Pacheco Alberto , Moreno Bayardo María Guadalupe , Ramírez Díaz José Antonio
Published: May 2021

El objetivo de este trabajo es realizar un análisis crítico sobre la manera en que las Reformas Educativas de 2013 y 2019 en México, han dado concreción a políticas educativas sexenales que escasamente incorporan estrategias pertinentes para responder a las necesidades educativas como tales. A partir de la investigación “Representaciones sociales de docentes de primaria acerca de la reforma educativa 2012”, estudio cualitativo apoyado en sucesivas entrevistas a profundidad; y de la revisión de fuentes hemerográficas en las que se plasmó la discusión nacional en torno a las reformas y sus consecuencias, se sustenta que, en términos de reformas educativas, ni la imposición carente de flexibilidad, ni el “diálogo” que cede a las presiones de los más férreos, benefician a la educación. Es necesario dejar de ubicar la toma de decisiones sobre la educación en el terreno de las pugnas de carácter político y de las luchas de poder.
Barreras en los procesos de Educación Inclusiva dirigidos a niños con Trastorno del Espectro Autista (TEA)
Authors: Bejarano Gómez Alejandro , Garzón Moreno Anyil Paola , Arias Huertas Paola Andrea
Published: May 2021

Objetivo: En esta investigación se buscó describir las percepciones de un grupo de docentes sobre los procesos de educación inclusiva en los que participan niños con trastorno del espectro autista (TEA) y sobre aquellos factores que atraviesan su instanciación y desarrollo. Método: la investigación involucró 12 participantes (docentes) de una institución educativa de la ciudad de Bogotá y se desarrolló entre los meses de mayo y octubre del año 2019. Se implementó un diseño de Teoría Fundamentada basado en la propuesta de Strauss y Corbin (1998) que se desarrolló a través de tres etapas; en las dos primeras se aplicaron entrevistas y en la tercera se realizó un grupo focal. Resultados: Los resultados de cada fase se analizaron siguiendo el procedimiento de la Codificación teórica (codificación abierta, codificación axial y codificación selectiva) propuesto por Strauss y Corbin (1998). Tras el desarrollo de las tres fases y la implementación de estrategias para garantizar calidad (p.e. auditoria por parte de un revisor externo al proceso de recolección y triangulación entre investigadores), se logró saturar una categoría central que emergería como un elemento común a las percepciones narradas por cada uno de los participantes: barreras que limitan los procesos inclusión. Al dimensionalizar esta categoría emergieron 4 subcategorías. 1) Barreras asociadas a los procesos de formación profesional para la diversidad; 2) Barreras asociadas a la participación de cuidadores en los procesos de educación inclusiva; 3) Barreras asociadas al uso de mediaciones efectivas y estrategias pedagógicas y didácticas para su uso en el aula de clase; 4) barreras asociadas a factores normativos y socioeconómicos. Se finaliza el texto sugiriendo posibles vías y estrategias que podrían llegar a articularse en una propuesta teórico-interventiva de carácter inclusiva que pueda contribuir al fortalecimiento de los procesos de educación inclusiva en el contexto de estudio y que sirva como guía para el desarrollo de otros procesos en otros contextos.
Fundamentos y Método de las Revisiones Sistemáticas
Authors: Berra Silvina
Published: May 2021

La práctica profesional requiere el manejo de la evidencia científica actualizada sobre los asuntos en los que a diario se deciden diagnósticos o intervenciones. Las revisiones sistemáticas (RS) son síntesis  cualitativas y, a veces, cuantitativas sobre la evidencia disponible respecto de un tema puntual. Este trabajo contextualiza su origen en el movimiento de la medicina basada en la evidencia y las define como un tipo de investigación orientada a buscar, evaluar y sintetizar conocimiento científico previamente producido. A fin de comprender la importancia de la exhaustividad y la rigurosidad del método, se distingue una RS de una revisión narrativa. El método de RS se presenta en una serie de fases o pasos que abarca desde el planteo de una pregunta de investigación, pasando por las estrategias de búsqueda y técnicas e instrumentos para la evaluación de calidad, extracción y análisis de datos, la posibilidad de un metanálisis y, finalmente la interpretación de resultados. Dentro de los criterios de evaluación de la evidencia científica, un pilar fundamental de este tipo de investigación, se explican la validez interna, la precisión y la validez externa de los resultados como componentes de la calidad, y la cantidad y la consistencia de la evidencia científica, a partir de las cuales se pueden establecer las recomendaciones.
Inulin, KCL, and Flavor Enhancers: An Efficient Combination to Produce Prebiotic and Low-Sodium Burgers
Authors: dos Santos Bibiana Alves , Cichoski Alexandre José , Campagnol Paulo Cezar Bastianello
Published: May 2021

In this study, prebiotic and low-sodium burgers were produced. In the first experiment, burgers were elaborated with 0, 3, 6, 9, and 12% inulin. The addition of up to 9% inulin did not affect the sensory quality, increased yield and reduced shrinkage. Thus, in the second experiment, prebiotic burgers were produced with 9% inulin and a sodium reformulation was performed by replacing 60% NaCl with KCl and adding monosodium glutamate (MG) and/or liquid smoke (LS). The replacement of NaCl for KCl impaired the sensory quality of the burgers. The isolated or combined addition of MG and LS reduced the sensory defects caused by KCl. Thus, prebiotic and low-sodium burgers with high technological and sensory quality can be produced using 9% inulin, 1% NaCl, 1.5% KCl, 0.2% MG, and 0.1% LS.
Determination of Aortic Characteristic Impedance and Total Arterial Compliance From Regional Pulse Wave Velocities Using Machine Learning: An in-silico Study
Authors: Bikia Vasiliki , Rovas Georgios , Pagoulatou Stamatia , Stergiopulos Nikolaos
Published: May 2021

In-vivo assessment of aortic characteristic impedance (Zao) and total arterial compliance (CT) has been hampered by the need for either invasive or inconvenient and expensive methods to access simultaneous recordings of aortic pressure and flow, wall thickness, and cross-sectional area. In contrast, regional pulse wave velocity (PWV) measurements are non-invasive and clinically available. In this study, we present a non-invasive method for estimating Zao and CT using cuff pressure, carotid-femoral PWV (cfPWV), and carotid-radial PWV (crPWV). Regression analysis is employed for both Zao and CT. The regressors are trained and tested using a pool of virtual subjects (n = 3,818) generated from a previously validated in-silico model. Predictions achieved an accuracy of 7.40%, r = 0.90, and 6.26%, r = 0.95, for Zao, and CT, respectively. The proposed approach constitutes a step forward to non-invasive screening of elastic vascular properties in humans by exploiting easily obtained measurements. This study could introduce a valuable tool for assessing arterial stiffness reducing the cost and the complexity of the required measuring techniques. Further clinical studies are required to validate the method in-vivo.
DNA Topoisomerase 3α Is Involved in Homologous Recombination Repair and Replication Stress Response in Trypanosoma cruzi
Authors: Costa-Silva Héllida Marina , Resende Bruno Carvalho , Umaki Adriana Castilhos Souza , Prado Willian , da Silva Marcelo Santos , Virgílio Stela , Macedo Andrea Mara , Pena Sérgio Danilo Junho , Tahara Erich Birelli , Tosi Luiz Ricardo Orsini , Elias Maria Carolina , Andrade Luciana Oliveira , Reis-Cunha João Luís , Franco Glória Regina , Fragoso Stenio Perdigão , Machado Carlos Renato
Published: May 2021

DNA topoisomerases are enzymes that modulate DNA topology. Among them, topoisomerase 3α is engaged in genomic maintenance acting in DNA replication termination, sister chromatid separation, and dissolution of recombination intermediates. To evaluate the role of this enzyme in Trypanosoma cruzi, the etiologic agent of Chagas disease, a topoisomerase 3α knockout parasite (TcTopo3α KO) was generated, and the parasite growth, as well as its response to several DNA damage agents, were evaluated. There was no growth alteration caused by the TcTopo3α knockout in epimastigote forms, but a higher dormancy rate was observed. TcTopo3α KO trypomastigote forms displayed reduced invasion rates in LLC-MK2 cells when compared with the wild-type lineage. Amastigote proliferation was also compromised in the TcTopo3α KO, and a higher number of dormant cells was observed. Additionally, TcTopo3α KO epimastigotes were not able to recover cell growth after gamma radiation exposure, suggesting the involvement of topoisomerase 3α in homologous recombination. These parasites were also sensitive to drugs that generate replication stress, such as cisplatin (Cis), hydroxyurea (HU), and methyl methanesulfonate (MMS). In response to HU and Cis treatments, TcTopo3α KO parasites showed a slower cell growth and was not able to efficiently repair the DNA damage induced by these genotoxic agents. The cell growth phenotype observed after MMS treatment was similar to that observed after gamma radiation, although there were fewer dormant cells after MMS exposure. TcTopo3α KO parasites showed a population with sub-G1 DNA content and strong γH2A signal 48 h after MMS treatment. So, it is possible that DNA-damaged cell proliferation due to the absence of TcTopo3α leads to cell death. Whole genome sequencing of MMS-treated parasites showed a significant reduction in the content of the multigene families DFG-1 and RHS, and also a possible erosion of the sub-telomeric region from chromosome 22, relative to non-treated knockout parasites. Southern blot experiments suggest telomere shortening, which could indicate genomic instability in TcTopo3α KO cells owing to MMS treatment. Thus, topoisomerase 3α is important for homologous recombination repair and replication stress in T. cruzi, even though all the pathways in which this enzyme participates during the replication stress response remains elusive.
Differences in Steady-State Erythropoiesis in Different Mouse Bones and Postnatal Spleen
Authors: Myneni Vamsee D. , Szalayova Ildikó , Mezey Eva
Published: May 2021

Adult erythropoiesis is a highly controlled sequential differentiation of hematopoietic stem cells (HSCs) to mature red blood cells in the bone marrow (BM). The bones which contain BM are diverse in their structure, embryonic origin, and mode of ossification. This has created substantial heterogeneity in HSCs function in BM of different bones, however, it is not known if this heterogeneity influences erythropoiesis in different bones and different regions of the same bone. In this study, we examined steady state BM erythroid progenitors and precursors from different bones – the femur, tibia, pelvis, sternum, vertebrae, radius, humerus, frontal, parietal bone, and compared all to the femur. Trabecular and cortical regions of the femur were also compared for differences in erythropoiesis. In addition, mouse spleen was studied to determine at which age erythropoietic support by the spleen was lost postnatally. We report that total erythroid cells, and erythroid precursors in the femur are comparable to tibia, pelvis, humerus and sternum, but are significantly reduced in the vertebrae, radius, frontal, and parietal bones. Erythroid progenitors and multipotential progenitor numbers are comparable in all the bones except for reduced number in the parietal bone. In the femur, the epiphysis and metaphysis have significantly reduced number of erythroid precursors and progenitors, multipotential progenitors and myeloid progenitors compared to the diaphysis region. These results show that analysis of erythroid precursors from diaphysis region of the femur is representative of tibia, pelvis, humerus and sternum and have significant implications on the interpretation of the steady-state erythropoiesis finding from adult BM. Postnatal spleen supports erythroid precursors until 6 weeks of age which coincides with reduced number of red pulp macrophages. The residual erythroid progenitor support reaches the adult level by 3 months of age. In conclusion, our findings provide insights to the differences in erythropoiesis between different bones, between trabecular and cortical regions of the femur, and developmental changes in postnatal spleen erythropoiesis.