bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and performance study of grease spoolless relief valve
Authors: Gong Guoqing , Wang Youmin , Zhou Bin
Published: June 2022

The high resistance characteristic of the grease delivery process makes the centralized lubrication system easy to cause pipeline blockage during the grease supply process. The main objective of the present article is to design a non-spool relief valve device based on the round pipe. The plug shape characteristics of the grease flow in the tube are established by combining the hydrodynamic equation and the grease rheological model. The mathematical model, whose relationship between velocity and flow is derived, is established with the core pipe of the grease sporeless relief valve of flow resistance, so the factors affecting grease pipe flow are obtained. The numerical simulation method is used to simulate the lipid overflow process of the simplified model with different influence parameters. Tecplot 360 EX 2015 R1 is used as a post-processing software to derive velocity and pressure clouds for grease flow in a circular tube, to investigate the factors influencing the relief pressure and relief capacity of the relief valve, to derive general rules for grease relief pressure, grease relief capacity and grease flow pattern distribution, and to establish an evaluation model for the relief pressure and relief capacity of the relief valve. The performance research test platform of the grease sporeless relief valve is built, and NLGI1 lithium grease is selected to carry out the experimental study on the performance of the grease relief valve under different influence parameters. The safety, stability, and feasibility of the overflow valve working with the pumping system are verified.
Is Surgical Pancreatic Necrosectomy Becoming Obsolete? ACS-NSQIP Trends and Predictors of Complications and Mortality
Authors: Liepert Amy Erna , Ventro George J , Weaver Jessica Lee , Berndtson Allison Elizabeth , Godat Laura Nadine , Adams Laura M , Santorelli Jarrett E , Costantini Todd Wilson , Doucet Jay Joseph
Published: June 2022

Background
Surgical pancreatic necrosectomy (SPN) is an option for management of severe acute pancreatitis. Literature indicates that an escalating, combined endoscopic, interventional radiology and minimally invasive surgery “Step-up” approach such as Video-Assisted Retroperitoneal Debridement (VARD) may reduce the number of required SPNs and ICU complications such as multiple organ failure. We sought to determine temporal trends for rates of SPN, and SPN-related mortality and complications.
Methods
The American College of Surgeons National Surgery Quality Improvement Program database (ACS-NSQIP) was used to find SPN cases from 2007–2019 in ACS-NSQIP submitting hospitals. Mortality and Clavien-Dindo class 4 (CD4) ICU complications were collected. Predictors of outcomes were identified by univariate and multivariate analyses.
Results
There were 2457 SPN cases. SPN cases decreased from 0.09% of records in 2007 to 0.01% in 2019 (p < 0.001). Overall mortality was 8.5% and did not decrease with time. CD4 complications decreased from 40–27% (p < 0.001). There was a 65% reduction in SPN cases requiring a return to the operating room. Multivariate predictors of complications were emergency general surgery (EGS, p < 0.001), serum albumin (p < 0.0001) and modified Frailty Index (mFI) (p < 0.0001). Multivariate predictors of mortality were EGS (p < 0.0001), serum albumin (p < 0.0001), and mFI (p < 0.04). mFI decreased after 2010 (p < 0.001).
Conclusion
SPNs decreased after 2010, with decreasing CD4 complications, decreasing reoperation rates and stable mortality rates, likely indicating broad adoption of a “Step-up” approach. Larger, prospective studies to compare indications and outcomes for SPN are warranted.
Evaluation of the impact of probiotics usage in aquaculture: A systematic review
Authors: Henry David Elisha , Basavaiah Renuka
Published: June 2022

In aquaculture, probiotics are widely used for preventing the diseases. Probiotics are live beneficial bacteria that are ingested into the gastrointestinal tract through food or water or any dietary supplement to boost immunity and internal microbial resistance. Several experimental studies have been undertaken on the effect of probiotics on the immune system of diverse aquatic animals, as well as the mechanism involved to control the harmful pathogens. As a result, the current study aims to conduct a systematic review to update the findings related to specific immunological markers. Relevant studies from PubMed, EMBASE, and Google Scholar were systematically searched until the latest issue. Experimental studies written in the English language were included in the review. The main outcome was to identify the insightful outcome about the impact of probiotics. Systemic review was performed for 12 studies. The SYRCL’S risk of bias tool for the animal study was also used to evaluate the quality of the included studies. In conclusion, the results of the current review study summarize that probiotic could boost the immune system of aquatic animals by increasing plasma immunoglobulin, cytokines, plasma lysozyme, respiratory burst, peroxidase, phagocytosis, and alternative complement activities.
Synthesis and Biological Evaluation of Thiosemicarbazone Derivatives
Authors: Gürdere Meliha Burcu , Doğan Murat , Koçyiğit Ümit M. , Ceylan Mustafa , Budak Yakup
Published: June 2022

In this study, firstly, 22 thiosemicarbazone derivatives (3a-y) were synthesized. Then, ADME parameters, pharmacokinetic properties, drug-like structures, and suitability for medicinal chemistry of these molecules were studied theoretically by using SwissADME and admetSAR programs. According to the results of these theoretical studies, it can be said that the bioavailability and bioactivity of these compounds may be high. In silico molecular docking between ligands (thiosemicarbazone derivatives) and targeted proteins (protein-78 (GRP78) for C6 and quinone reductase-2 (4ZVM for MCF 7) was analyzed using Hex 8.0.0 docking software. According to the docking data, almost all molecules had higher negative E values than Imatinib (already used as drug). For this, in vitro anticancer studies of these molecules were done. The cytotoxic activities of thiosemicarbazone derivatives (3a-y) were evaluated on C6 glioma and MCF7 breast cancer cell lines at 24 hours, and Imatinib was used as positive control. According to the results of cytotoxicity assay, it can be said that the five compounds (3b, c, f, g and m with IC50 = 10.59–9.08; Imatinib IC50 = 11.68) showed more potent cytotoxic activity than Imatinib on C6 cell line. Together with to these results ten compounds (3b, d, f, g, I, k, l, m, n and r with IC50 = 7.02–9.08; Imatinib IC50 = 9.24) had more effective cytotoxic activity against MCF7 cell line than Imatinib. Compound 3m showed the highest antiproliferative effect against C6 and MCF7 cell lines.
Control of Monomeric Vo’s vs. Vo clusters in ZrO2-x for Solar-Light H2 Production from H2O at High-Yield [millimoles gr-1 h-1]
Authors: Deligiannakis Yiannis , Mantzanis Asterios , Zindrou Areti , Smykala Szymon , Solakidou Maria
Published: June 2022

Pristine zirconia, ZrO2, possesses high premise as photocatalyst due to its conduction band energy edge. However, its high energy-gap is prohibitive for photoactivation by solar-light. Currently, it is unclear how solar-active zirconia can be designed to meet the requirements for high photocatalytic performance. Moreover, transferring this design to an industrial-scale process is a forward-looking route. Herein, we have developed a novel Flame Spray Pyrolysis (FSP) process for generating solar-light active nano-ZrO2-x via engineering of lattice vacancies, Vo. Using solar photons, our optimal nano-ZrO2-x can achieve milestone H2-production yield, >2400 μmolg-1h-1 (closest thus, so far, to high photocatalytic water splitting performance benchmarks). Visible light can be also exploited by nano-ZrO2-x at a high yield via a two-photon process. Control of monomeric Vo vs. clusters of Vo’s is the key parameter toward Highly-Performing-Photocatalytic ZrO2-x. Thus, the reusable and sustainable ZrO2-x catalyst achieves so far unattainable solar activated photocatalysis, under large scale production.
Open-Source Workflow Design and Management Software to Interrogate Duckweed Growth Conditions and Stress Responses
Authors: Scott Madeline , de Lange Orlando , Quaranto Xavaar Chayton , Cardiff Ryan , Klavins Eric
Published: June 2022

Duckweeds, a group of floating aquatic plants, are ideal model plants for laboratory experiments because they are small, easy to cultivate, and reproduce quickly. Duckweed laboratory biology, however, requires that lineages are maintained as continuous populations of asexually propagating fronds, so research teams need to calibrate cultivation conditions and coordinate maintenance tasks for duckweed stocks. Computational image data analysis is proving a powerful duckweed research tool, but researchers lack software tools to assist with data collection and storage in a way that can feed into scripted data analysis. We set out to support these processes — cultivation, and subsequent integration with data analysis tools — using a laboratory management software called Aquarium, an open-source application developed to manage laboratory inventory and plan experiments. We developed a suite of duckweed cultivation and experimentation operation types in Aquarium, which we then integrated with novel data analysis scripts. We then demonstrated the efficacy of our system with a series of image-based growth assays, and explored how our framework could be used to calibrate cultivation protocols. We discuss the unexpected advantages and the limitations of this approach, suggesting areas for future software tool development. In its current state, our approach helps to bridge the gap between laboratory implementation and data analytical software for duckweed biologists and builds a foundation for future development of end-to-end computational tools in plant science.
The impact of a web-based pre-intubation preparation module on the knowledge, skills and behavior of critical care fellows.
Authors: Alroumi Fahad , Dinino Ernest , Tidswell Mark , Blanchard Rebecca , Shatzer John
Published: June 2022

Background: It is a priority to have critical care trainees acquire competency in pre-intubation airway assessment and preparation. We describe the design, implementation, and evaluation of a novel web-based training module on critical care fellows’ ability to assess, predict and prepare for tracheal intubation. Methods: A needs assessment from fellows and from faculty found that structured training on intubation preparation and airway risk assessment was essential. We therefore designed an online module that combines mandatory readings, brief lectures and a case-based virtual activity. In addition to learner satisfaction, the outcome constructs of this module include improvements in fellows’ pre-intubation preparation assessment knowledge, skills, safety-oriented behaviors. Paired t-test was used to compare knowledge assessment scores pre and post module. Chi-square test was used to compare pre and post data for the categorical variables in the evaluation of the skill and behavior constructs. Results: All trainees (N=14) completed the module, and they were satisfied with its contents and structure. The mean score on the knowledge assessment increased significantly (from 79.9% to 90.3%, p =0.02). There was a total of 290 intubations logged by the fellows during the study period. First pass success did not significantly change after the module (88.6% vs 94.3%, p=0.89). There was a significant change in procedural note documentation to include at least one airway risk parameter in the fellow authored notes (65.9% vs 72.9%, P=0.049). All respondents were confident that they will be able to apply what they have learned in the module into clinical practice and that their patients will benefit from their new knowledge. Conclusion: The implementation of an asynchronous web-based module on airway assessment and intubation preparation was feasible. The module was engaging, enhanced knowledge of our trainees and improved procedural documentation.
Safety and short-term efficacy of gastrectomy after preoperative chemotherapy plus immunotherapy versus preoperative chemotherapy: A retrospective cohort study
Authors: Lei Xiaokang , Wang Yinkui , Shan Fei , Li Shuangxi , Jia Yongning , Miao Rulin , Xue Kan , Li Zhemin , Ji Jiafu , Li Ziyu
Published: June 2022

Purpose This study was conducted to compare the safety and short-term efficacy of gastrectomy after preoperative chemotherapy plus immunotherapy (PCIT) versus preoperative chemotherapy (PCT) in patients with advanced gastric cancer (AGC).Methods We retrospectively reviewed the data of patients with AGC who received PCIT or PCT at Peking University Cancer Hospital and Institute Gastrointestinal Cancer Center I between January 2019 and June 2021. The clinical characteristics were recorded, and short-term oncological outcomes were compared. Independent t-tests, Mann-Whitney U tests, Chi-square tests, and Fisher’s exact tests were used to calculate differences. The correlation analyses were performed using Pearson correlation. All p values were two-sided, and a p-value <0.05 was considered as statistically significant. All the above statistical analyses were conducted by the SPSS version 24.0 software package (IBM Corp., Armonk, NY, USA).Results A total of 162 AGC patients were included in this study, including 25 patients receiving PCIT and 137 patients receiving PCT. There were no significant differences in preoperative treatment-related adverse events (TRAEs) between the PCIT group and the PCT group (p=0.088). Compared with the PCT group, the PCIT group had comparable postoperative functional recovery, with no significant differences in terms of the first aerofluxus time (p=0.349), the first defecating time (p=0.800), the first time on liquid diets (p=0.233), and length of stay (p=0.278). No significant differences were observed in terms of postoperative complications (p=0.952), postoperative pain intensity at 24, 48, and 72 hours (p=0.375, p=0.601, and p=0.821, respectively), and postoperative supplementary analgesic between the two groups (p=0.881). In addition, the postoperative complication rates were 33.3% following the laparoscopic approaches and 31.2% following the open approaches in the PCIT group, with no significant difference (p=1.000).Conclusions In patients with AGC, gastrectomy with D2 or D2+ lymphadenectomy after PCIT was comparable to PCT in terms of short-term oncological outcomes. The safety of LG was similar to that of OG in patients with AGC after PCIT.
Fatigue status quo of children and adolescents with inflammatory bowel disease and its influencing factors in China: a cross-sectional study
Authors: Cao Jinjin , Wang Yuanyuan , Huang Yan , Ren Lei , Li Mei
Published: June 2022

Background: In recent years, the global diagnosis rate of inflammatory bowel disease of children and adolescents has been increasing. Fatigue was found to be the most exhausting symptom in inactive disease and the second most exhausting symptom in active disease. However, little is known about fatigue in pediatric inflammatory bowel disease. Hence, the aim of this study is to investigate the prevalence and status of fatigue in a cohort of pediatric inflammatory bowel disease patients in China.Methods: A cross-sectional, questionnaire-based survey was conducted. The researchers recruited convenience samples of patients with inflammatory bowel disease from Department of Gastroenterology of a children’s hospital located in Nanjing, China. The prevalence and status of fatigue were measured by a questionnaire, and associations potential factors were examined using multiple regression analysis.Results: The total score of fatigue in children with inflammatory bowel disease was 62.22±20.55. The results of univariate analysis of fatigue degree in patients with inflammatory bowel disease showed a significant difference among regions, age, disease severity, corticosteroids and biological agents (p< 0.05).Conclusions: Fatigue was a multidimensional symptom, and most pediatric patients with inflammatory bowel disease were distressed by fatigue symptom. The patient’s region, age, disease severity, BMI and drug use were the significant predictors of fatigue. Health care providers should pay attention to the patient’s fatigue symptom. After the initial assessment of the patient’s fatigue, the targeted interventions should given to improve the symptom.
Dietary and Pharmacological Management of Plasma Glucose, Triglyceride and Glycated Hemoglobin among Patients with Type 2 Diabetes Mellitus
Authors: Natour Nihal , Bakri Fatma , Al-Tell Mariam , Shaheen Amera
Published: June 2022

Introduction: Diabetes mellitus type 2 (DM2) is among leading causes of mortality in Occupied Palestinian territories and providing data on its level of management using pharmacological and dietary approaches is important to provide policy makers of possible gaps in clinical practice.Aims: we aimed to study the level of control of recently diagnosed patients with DM2 and patterns of pharmacological treatment and dietary intakes in relation to clinical endpoints.Methods: we used semi-structured questionnaire, medical records, anthropometric measurements and biochemical measurements to assess plasma glucose, Glycated hemoglobin (HbA1C), medical and medication history, measurement of obesityResults105 participants were included in this analysis with few missing data for some sub-analysis. Average age was (56.8 ± 8.1 y), medians for glucose (160 (150, 180)mg/dl ), Triglyceride (TG (155 (140, 170) mg/dL ), HbA1C (8 (7, 9)%). Metformin was associated with best HbA1C control compared to groups who used insulin (p< 0.01). Also, HbA1C and glucose were different across fish intake categories. Nuts were associated with modest improvement in HbA1C. Plasma TG was not modified by study variables.ConclusionMetformin, fish intake and nuts intake were associated with improvement in glucose and HbA1C among diabetic patient in Palestinian territories.
Changes in social behavioral developmental risks in preschool children after the first COVID-19 wave – results from a prospective cohort study
Authors: Kästner Anika , Ernst Vanessa Sophie , Hoffmann Wolfgang , Franze Marco
Published: June 2022

Since the outbreak of the COVID-19 pandemic, in many countries preschool and school closures were common, especially at the beginning of the pandemic. The impact of the pandemic on developmental risks in the social-emotional domain of preschool children is largely unknown. In this prospective dynamic cohort study social behavioral developmental risks were longitudinally assessed with the “Dortmund Developmental Screening for Preschools (DESK 3-6 R)”. Therefore, DESK 3-6-R data from 3-year-olds at survey wave 3 (DESK-R-SW3, 2019) and 4-year-olds at survey wave 4 (DESK-R-SW4, 2020) were used. In addition, data assessed in previous survey waves were analyzed to contextualize the observed changes. A total of N=786 children were included in the analysis. In DESK-R-SW3 the proportion of children with social behavioral developmental risks/inconclusive findings was 18.2%, whereas in DESK-R-SW4 the proportion decreased to 12.4%. The prevalence rate ratio (PRR) was therefore 0.68 (p=0.001). Compared to data from the previous survey waves (PRR=0.82; PRR=0.88), this result represents a notable improvement. No deteriorations in the prevalence of preschoolers’ social behavioral development risks after the first COVID-19 wave could be observed. The results are discussed in the framework of the pandemic situation in the study region and the current literature.
Interaction between a screw dislocation and an elastic elliptical inhomogeneity by using the angular basis function
Authors: Chen J.-T. , Lee J. W. , Kao S. K.
Published: June 2022

The behavior of displacement field due to a screw dislocation is similar to the angular basis function (ABF) Arg(z). It is different from the radial basis function (RBF) ln(r) that is used to describe the velocity potential of a sink or source. Nevertheless, the complex-valued fundamental solution ln(z) contains the two parts of RBF ln(r) and ABF Arg(z). In this paper, not only the RBF in the null-field boundary integral equation (BIE) but also the ABF for the screw dislocation are employed to study the interaction between a screw dislocation and an elastic elliptical inhomogeneity. This problem is decomposed into a free field with a screw dislocation and a boundary value problem containing an elliptical inhomogeneity. The boundary value problem is solved by using the RBF and the null-field BIE. Since the geometric shape is an ellipse, the degenerate kernel is expanded to a series form under the elliptical coordinates, while the unknown boundary densities are expanded to eigenfunctions. By combining the degenerate kernel and the null-field BIE, the boundary value problem can be easily solved. The inconsistency between Sendeckyj [1] and Gong & Meguid [2] for the problem was also found by using the present approach. The error in [2] was also printed out. Finally, some examples are demonstrated to verify the validity of the present approach.
Complete response of RCC to autologous T cell immunotherapy following progression on immune checkpoint inhibitor, A case report
Authors: Ren Jun , Wu Tiecheng , li Congcong , Wang Xiaoli , Hu Lina , Zhou Xinna , Bao Xuhui , Wan Kun , Zeng Chuxiong , Sun Bo , Lou JingJing , Liu Xingdang , Hobeika Amy , Morse Michael A. , Lyerly Herbert Kim
Published: June 2022

Background: The renal clear cell carcinoma (RCCC) is a frequent occurrence of kidney cancer, such tumor was concealed progressed until symptomatic developed or through imaging examination. More recently, targeted therapies, immunotherapy and their combinations have improved outcome .However seeking the novel salvage treatment of second-line or above of post-immunotherapy has been warranted.Case presentation: A 55-year-old man diagnosed with non-VHL associated renal clear cell carcinoma presented 8 years ago. The upper abdominal distention and hematochezia were noticed after 6 years of nephrectomy, surgically confirmed pancreas-duodenal metastatic lesions 1.5 years ago to preclude the second primary carcinoma. Despite eight cycles of pembrolizumab plus axitinib after surgery, liver multiple masses progress rapidly. Following four cycles of autologous adoptive T cell immunotherapy and hyperthermia with low dose pembrolizumab, all metastatic lesions demonstrated complete responses. No serious adverse events were reported.Conclusions: This triple combination of adoptive T cell therapy, low dose immune checkpoint blockade, and hyperthermia has been salvage treatment for RCCC.
The impact of thickness heterogeneity on soft tissue biomechanics: A novel measurement technique and a demonstration on heart valve tissue
Authors: Lin Chien-Yu , Mathur Mrudang , Malinowski Marcin , Timek Tomasz A. , Rausch Manuel K.
Published: June 2022

The mechanical properties of soft tissues are driven by their complex, heterogeneous composition and structure. Interestingly, studies of soft tissue biomechanics often ignore spatial heterogeneity. In our work, we are therefore interested in exploring the impact of tissue heterogeneity on the mechanical properties of soft tissues. Therein, we specifically focus on soft tissue heterogeneity arising from spatially-varying thickness. To this end, our first goal is to develop a non-destructive measurement technique that has a high spatial resolution, provides continuous thickness maps, and is fast. Our secondary goal is to demonstrate that including spatial variation in thickness is important to the accuracy of biomechanical analyses. To this end, we use mitral valve leaflet tissue as our model system. To attain our first goal, we identify a soft tissue-specific contrast protocol that enables thickness measurements using a Keyence profilometer. We also show that this protocol does not affect our tissues' mechanical properties. To attain our second goal, we conduct virtual biaxial, bending, and buckling tests on our model tissue both ignoring and considering spatial variation in thickness. Thereby, we show that the assumption of average, homogeneous thickness distributions significantly alters the results of biomechanical analyses when compared to including true, spatially-varying thickness distributions. In conclusion, our work provides a novel measurement technique that can capture continuous thickness maps non-invasively, at high resolution, and in short time. Our work also demonstrates the importance of including heterogeneous thickness in biomechanical analyses of soft tissues.
Proposed introduction of the SBAR method in rehabilitation
Authors: Tedeschi Roberto , Betti Fabio
Published: June 2022

This project aims to implement within the Rehabilitation Operative Unit of the Ausl of Bologna the standardised SBAR (Situation-Background-Assessment-Recommendation) method for the transfer of information between physiotherapists, in order to improve the safety of the care pathway. This project, promoted by the DATeR Direction of the Ausl of Bologna (Technical and Rehabilitation Assistance Direction), is characterised by the insertion of the SBAR form within some of the company's care units. Professional physiotherapists from some of the Care Units under the Rehabilitation Operational Unit were involved. The rehabilitation SBAR card was introduced in the Care Units involved in the following 6 months. The implementation phase was characterised both by the use of the tool and by periodic peer-to-peer meetings which animated discussions and comparisons on the specific contents concerning the card. Monthly sample checks were carried out on some completed SBAR forms to monitor their correct filling in. Finally, the opinion of all the physiotherapists of the 4 Care Units was surveyed through the administration of a semi-structured questionnaire. The SBAR rehabilitation form was therefore officially implemented from January 2020 in the 4 Care Units involved in the project. A further improvement project is planned to implement the use of the rehabilitation SBAR card in the entire Rehabilitation Unit.
Evaluation of a new performance-based, disease-specific health literacy measurement tool for patients with chronic airways diseases: the Vancouver Airways Health Literacy Tool (VAHLT)
Authors: Poureslami Iraj , Kopec Jacek A. , Sawatzky Rick , Hohn Ric , Aaron Shawn D. , Gupta Samir , Goldstein Roger , Lavoie Kim L. , Boulet Louis-Philippe , Tregobov Noah , Shum Jessica
Published: June 2022

Background: Low health literacy (HL) is a global challenge. HL is positively correlated with chronic airways disease (CAD) outcomes. Despite the importance of HL in disease management, current HL measurement tools are suboptimal. As part of a multi-stage project to develop a performance-based, disease-specific Vancouver Airways Health Literacy Tool (VAHLT) for patients with CAD, this study assessed the relationships between VAHLT scores and CAD patient characteristics. The primary aim of the study is to provide preliminary evidence of construct validity of the VAHLT. Methods: A cross-sectional study design was applied. Patients were recruited from 6 specialty care clinics to complete the measurement tool. Demographic and clinical data, including quality of life (QOL) and disease control, were collected via validated questionnaires. Subjects also completed spirometry. Inferential analysis was conducted using mean difference testing and correlational methods. Results: 320 patients were recruited, and after imputing missing data, 315 were ultimately analyzed. Participants were predominantly female (60.5%), Caucasian (83.1%), had post high-school education (74.2%), with a mean age of 65.2 (SD = 13.17) years. Age was significantly negatively correlated with HL scores (p = .004); patients with post-high school education had significantly higher HL scores than those with a high school education or less (p < .001). No significant sex or ethnicity related differences in HL scores were observed. For clinical outcomes, no significant differences were found between HL scores and disease severity or measures of QOL and asthma control. Conclusions: We report a CAD-specific HL measurement tool developed with involvement of patients and professionals. Age and education were highly correlated with HL, which emphasizes the importance of addressing these factors in HL interventions among CAD patients. In the next phase, we will evaluate the tool’s responsiveness to interventions.
Mapping and determinants of consumption of egg and/or flesh foods and zero vegetables or fruits among young children in SSA
Authors: Hailu Bayuh Asmamaw , Geremew Bisrat Misganew , Liverani Silvia , Abera Kindiye Setargie , Beyene Joseph , Miheretu Birhan Asmame
Published: June 2022

Zero vegetable or fruit and egg and/or flesh foods are the latest indicators for assessing infant and young child feeding practices. Understanding national and subnational heterogeneity and regional clustering in children with SSA is becoming increasingly essential for geographic targeting and policy prioritization. Geographical case identification, determinants, and impacts were all investigated. SSA children's consumption of vegetable or fruit, egg and/or flesh food, and both were low. In SSA, some portions of the Southern, South direction of the Western and Central regions have a lower weight of all bad conditions than others, although children continue to suffer in considerable numbers in all disadvantage circumstances. Children under the age of one year, from rural areas, uneducated families, and low income were all disadvantaged by both feeding techniques. To improve child nutrition status, multisectoral collaboration is essential. This framework allows for the tracking, planning, and implementation of nutritional treatments.
STUDI KRITIS PENDIDIKAN TOLERANSI DI INDONESIA
Authors: Anwar Ervan Choirul
Published: June 2022

Indonesia. Pemetaan dalam pembahasan artikel ini meliputi tema-tema yang sering digunakan dalam penelitian sebelumnya dan implementasi pendidikan toleransi di Indonesia. Penelitian ini menggunakan metode kualitatif literature review dengan pendekatan Systematic Review. Pengumpulan data dilakukan menggunakan Google Schoolar dengan memasukkan kata kunci “Pendidikan Toleransi” dan terbatas pada artikel yang diterbitkan dalam lima tahun terakhir (2015-2020). Artikel tersebut kemudian diolah untuk memetakan tema-tema yang sering digunakan oleh peneliti sebelumnya. Kemudian dianalisis untuk mendapatkan gambaran tentang aspek fokus kajian, metode, dan model pelaksanaan pendidikan toleransi di Indonesia. Hasil pembahasan menunjukkan bahwa penelitian dengan topik pendidikan toleransi telah banyak dilakukan di sekolah dan pesantren. Kajian lebih banyak dilakukan dengan mengintegrasikan pendidikan toleransi dengan pendidikan agama. Sementara itu, penguatan pendidikan toleransi dengan nasionalisme atau kebangsaan masih kecil. Selain itu, topik pendidikan toleransi di masyarakat belum terlalu banyak dipelajari. Sementara itu, pelaksanaan pendidikan karakter di sekolah, pondok pesantren dan masyarakat dilakukan dengan menggunakan empat pendekatan. Pertama, integrasi pendidikan toleransi dengan pendidikan multikultural. Kedua, integrasi pendidikan toleransi dengan Pendidikan Agama Islam. Ketiga, integrasi pendidikan toleransi dengan pembelajaran. Keempat, suri tauladan kyai.

 

Kata Kunci : Pendidikan, Toleransi, Indonesia
EVALUASI KURIKULUM PEMBELAJARAN BAHASA ARAB UNTUK PERBAIKAN MUTU AKADEMIK DI MI MAMBAUL MA’ARIF
Authors: Chasanah Uswatun , Prastowo Andi
Published: June 2022

Abstract: The research was conducted to find out the form of instruments used in the evaluation of the Arabic language learning curriculum in MI. This study uses a case study method at MI Mambaul Ma'arif. The research subject of the teacher of Arabic subjects. Data collection techniques with interviews, observations, and documentation studies. The data analysis technique is carried out by inductive analysis techniques. The results revealed that there are four types of curriculum evaluation, namely formative evaluation, summative evaluation, input evaluation, and product evaluation. The instrument forms used are test and nontest. Test instruments are classified into nen types, and twelve types of non-test types. The selection of instrument forms must be following the needs and characteristics of the learners. And teachers have no difficulty in making and implementing these forms of instruments when conducting evaluations either in the form of tests or nontests. If the results shown have not reached the minimum standard, it is necessary to provide follow-up in the form of remedial activities. And if it has reached the minimum standard, enrichment activities may be given.
MEMPERKUAT PAHAM MODERASI BERAGAMA DALAM MENANGKAL NARASI KEBENCIAN DI MEDIA SOSIAL
Authors: Burhanuddin Hamam , Khumaini Fahmi
Published: June 2022

The stigma of thoughts and movements to be radical and smells of violence still surrounds life in Indonesia, this is behind the importance of moderate Islamic thought by "Islam wasatiyah". This paper explain about strengthening religious moderation to counter hate narratives on social media. The study in this paper is qualitative. The conceptual framework offered uses a constructivist paradigm where technology seen as a product of social construction. The agent-structure approach is base on Giddens' theory of structuration. The technology studied is social media technology, while the agent in question is a social media user, then communication culture is place as a social structure that acts as a wider context. The conceptual framework as described here is especially useful for describing the relationship between technology and society and answering the question of how the interplay between technology and social behavior occurs in society.
Mn substitution and distribution in goethite and influences on its photocatalytic properties: A combined study using first-principles calculations and photocatalytic experiments
Authors: Liu Xin , Liu Huan , Zong Meirong , Chen Meng , He Hongping , Wang Rucheng , Lu Xiancai
Published: June 2022

Goethite and modified goethites have been found as good photocatalysts because their conduction band can mediate electron transfer in various redox processes. Many kinds of metal elements can be incorporated into the structure of goethite to form solid solutions in nature, but their optoelectronic properties have not been well disclosed. Mn-substituted goethite is one of the potential photocatalysts, which can exhibit high-photocatalytic activity in many Earth’s surface processes. Based on the first-principles calculation, pairwise interaction energies and static lattice energies of goethitegroutite solid solution were computed, and the most thermodynamically stable configurations of Mn-substituted goethite were determined. The results indicate that Mn3+ ion tends to distribute within the cation layer parallel to the (001) plane. Phase relations of goethite-groutite solid solution were derived by subsequent configurational statistics with energies of all 232 configurations of a 2 × 1 × 4 supercell with 32 exchangeable cations. The phase diagram shows that no more than 3 mol% Fe of goethite can be substituted by Mn ions. Therefore, Mn-substituted goethite is thermodynamically metastable or bears groutite-like clusters/lamellae. Furthermore, the effects of Mn substitutions on the band gap were experimentally and theoretically investigated. It is found that a small amount of Mn-substitution can reduce the band gap of goethite significantly, and the decrease ceases when the Mn content is higher than 3–4 mol%. Such a decrease in band gap causes red-shift to the photo response wavelength of goethite and improves the responding capability. This improvement was confirmed in the experiments of photocatalytic degradation of methylene blue (MB). Such kind of photocatalytic reaction probably can happen widely in natural environments. Therefore, the contribution of photocatalysis of natural goethites to geochemical processes on Earth’s surface should be considered.
Recycled carbonates in the mantle sources of natural kamafugites: A zinc isotope perspective
Authors: Ma Lei , Liu Sheng-Ao , Zhao Zhidan , Yu Xue-Hui
Published: June 2022

Kamafugites are strongly silica-undersaturated melts that are difficult to produce by partial melting of volatile-free peridotites but can be produced experimentally in the presence of CO2. Nevertheless, there is not yet direct evidence for a CO2-rich mantle source and the possible presence of recycled carbonates in the source of natural kamafugites. Marine carbonates have a heavier zinc isotopic composition (δ66Zn) than that of the mantle by up to 1.0‰, making zinc isotopes a sensitive tracer for recycled carbonates in the sources of mantle-derived magmas. Here we take Cenozoic kamafugites from the West Qinling orogen in China as an example to address the origin of this rare volcanic rock. The West Qinling kamafugites are strongly silica-undersaturated (SiO2 = 37.0 to 43.0 wt%) and have significantly higher δ66Zn (0.30‰ to 0.47‰) than that of the normal mantle (0.18 ± 0.05‰). No correlation between δ66Zn and MgO or SiO2 contents is observed, indicating that the high δ66Zn was not a result of magmatic differentiation. Modeling of melting indicates that even at extremely low degree (~0.5%), partial melting of a normal peridotitic source is still unlikely to produce silicate melts with δ 66Zn values exceeding 0.30‰. Thus, the elevated δ66Zn of the West Qinling kamafugites demonstrates the presence of recycled carbonates in their mantle sources. Binary-mixing modeling suggests that the source contains ~5 to 15% recycled carbonates, which is supported by the positive correlation between δ66Zn and CaO/Al2O3. Overall, the West Qinling kamafugites represent the products of low-degree partial melting of a recycled carbonate-bearing peridotite source, which provides evidence for an important role of recycled carbonates in the origin of natural kamafugite suites.
The Effect of Different Doses of Intraamniotic Digoxin on the Timing of Fetal Demise in Second Trimester Medical Abortions
Authors: Aynaoglu Yildiz Gulsah , Al Ragip Atakan
Published: June 2022

OBJECTIVES: The World Health Organization recommends feticide for termination of pregnancy after 20 weeks of gestation, and the Royal College of Obstetricians & Gynecologists after 21 weeks and 6 days. Digoxin is a commonly used feticidal agent. This retrospective study aimed to show the effect of different doses of digoxin on the timing of fetal demise when used for feticide.
STUDY DESIGN: Our retrospective cohort study included 57 patients who underwent feticide by routine intra-amniotic digoxin 0.75 mg or 1 mg between 2016 and 2018 at the Ataturk University Medical Faculty Research Hospital. The patients were administered undiluted digoxin 0.75 mg (3 ccs) or 1 mg (4 ccs) with a 20-gauge spinal needle inserted through the amniotic membrane. After digoxin administration, the fetal heartbeat was monitored every hour by ultrasound, and recorded.
RESULTS: In this retrospective study, we reviewed the data of 61 patients who underwent feticide by intra-amniotic digoxin 0.75 mg and 1 mg. Digoxin 3 ccs (n=23) and digoxin 4 ccs (n=34). The two groups were not significantly different in terms of age, gestational week, and termination indications. We reviewed the medical records of all subjects and noted any side effects.
CONCLUSIONS: In our study, we investigated the effect of different doses of intra-amniotic digoxin on the fetal demise in accordance with the literature. Despite our small sample size, we conclude that a higher dose of digoxin will reduce the time to asystole and minimize the mental burden of the procedure on the patient.
Groundwater Assessment and Management for sustainable water-supply and coordinated subsurface drainage
Authors: Foster Stephen , Gogu Radu
Published: June 2022

Groundwater beneath cities is important. Water utilities and private abstractors use is it as a secure source of water-supply and municipal authorities have to cope with it when planning sanitation and using underground space for building and transportation infrastructure, but all too often neither have a comprehensive understanding. This Guidebook aims to highlight what water utilities and municipal government can do to improve groundwater assessment, management and monitoring to avoid experiencing ‘nasty surprises’.

Groundwater, especially from deeper aquifers, is a critical resource for enhancing urban water-supply security under climate-change stress. But to achieve its use sustainably will require adaptive promotion of resource management and protection, according to local circumstances. In recent times municipal governments are making much more use of urban subsurface space (especially down to 15-metres depth) for construction. Traditionally the drainage and stability of such structures were achieved by individual site investigation, but today a more coordinated approach is needed to managing shallow groundwater conditions.

The Guidebook is divided into three complementary parts: Part A is intended for guidance of water-utility, together with water-resource agency and municipal sanitation department, staff working to improve urban water-supply resilience, with its inevitable requirement to get more involved in groundwater management. Part B is intended for guidance of municipal government authorities working to improve the design and execution of urban infrastructure to avoid potentially costly subsurface drainage issues, structural instability and groundwater flooding problems. Part C provides a series of case histories on urban groundwater management from around the world.

ISBN: 9781789063103

EISBN: 9781789063110

ePub: 9781789063127
Physio-chemical and heavy metal assessment of groundwater near dumping sites in Srinagar District, Jammu & Kashmir-India
Authors: Hafiz Imran , Singla Sandeep , Hafiz Bisma Zahoor
Published: June 2022

The present study is aimed to analyze and assess the critical quality parameters of ground water in district Srinagar spread over distinct seasons of the year 2020. The analysis was carried out on 15 Physio-Chemical quality parameters and 6 trace element concentrations (Lead, Zinc, Cadmium, Chromium, Nickel & Copper). Primary data was collected from 6 distinct sites of the district and subjected to methodical analysis. It was revealed that the mean values of various physio- chemical parameters are within the prescribed permissible levels while as heavy metal concentrations exhibit an escalating tendency across all selected sites especially GW1 (Pb 329, Cu 86, Ar 61, Zn 191), GW2 (Zn 132) and GW3 (Zn 144, Ar 67). The results indicate that waste disposal mechanism in hospitals of Srinagar is not environmental conducive and there is necessity to prevent further denigration of ground water sources in the region. Not denying that the present work is not the panacea for ground water contamination but the methodology adopted for this study is expected to pave way for further hydro-geological analysis in the region to identify the critical quality issues and also to explore remedial strategy to conserve the qualitative characteristics of ground water in the region.
Direct Monosaccharide Composition And N-Linked Oligosaccharide Analysis of Pvdf-Cartridge Immobilized Glycoproteins
Authors: O'Neill Roger , Somack Ralph , Olechno Joseph D.
Published: June 2022

PVDF membrane-containing ProSpinncTM and ProSorbTM cartridges, designed for preparation of proteins and pep­ tides for amino acid and sequence analysis, can also be used for glycoprotein sample preparation and carbohy­ drate analysis. These devices concentrate samples from large volumes and remove interfering substances. Com­
position analysis and N-linked oligosaccharide "fingerprint" analysis can be performed directly on the PVDF
membrane, using kits available from Perkin-Elmer.
Monte Carlo analysis of potential C-terminal membrane interactive α-helices
Authors: Pewsey Arthur R. , Phoenix David A. , Roberts Martin G.
Published: June 2022

Known membrane anchors of four prokaryotic carboxypeptidases were compared to the membrane interactive toxin melittin and an endopeptidase which contains a potential membrane anchor. Existing methodologies based on hydrophobic moment profile analysis have been extended to place them on a more rigorous statistical footing. All four carboxypeptidase anchors were predicted to contain a segment of surface active amphiphilic α-helix and the endopeptidase was predicted to be weakly membrane interactive.
Resin-Coupled Cyclic Peptides as Proteinase Inhibitors
Authors: McBride Jeffrey D. , Harbeck Birgit , Leatherbarrow Robin J.
Published: June 2022

Many screening methodologies applicable to combinatorial peptide libraries require that the peptide is presented in a biologically active form while remaining covalently-coupled to a synthetic support. Here we describe methodology appropriate to the generation of disulfide cross-linked cyclic peptides that allow high efficiency on­ resin cyclisation. This is applied to the generation of a resin-bound cyclic proteinase inhibitor peptide, which is shown to retain enzyme binding activity.
AGAP2-AS1: An Indispensable lncRNA in Tumors
Authors: Wang Bei , Chen Jinlan
Published: June 2022

Background:

LncRNA has been found to participate in a variety of biological processes
and play an important role in the occurrence and development of tumors. Therefore, it is of vital
clinical value to study the relationship between lncRNA and tumor. It has been confirmed that
lncRNA affects tumor progression through sponge mRNA, regulation of signal pathways and activity
of oncogenes. Recent studies have shown that LncRNA AGAP2-AS1 is closely related to
tumor, because this review focuses on the molecular mechanism of LncRNA AGAP2-AS1 affecting
tumor progression.

Methods:

The role of LncRNAAGAP2-AS1 in tumor was summarized by searching the literature
related to LncRNAAGAP2-AS1 from PubMed in recent years.

Results:

LncRNA AGAP2-AS1 is abnormally expressed as an oncogene in tumors, which participates
in biological processes such as tumor proliferation, migration, invasion and autophagy.
LncRNA AGAP2-AS1 plays an important role in tumorigenesis and development by binding to
mRNA, regulating signal pathway and affecting protein activity, which suggests that AGAP2-
AS1 may play a great potential value in the treatment of human cancer.

Conclusion:

The abnormal expression of LncRNAAGAP2-AS1 plays an important role in the
progression of tumor and has a promising value in the treatment of tumor. Exploring the molecular
mechanism of lncRNA AGAP2-AS1 is of indispensable significance for tumor treatment.
Capecitabine and Hand-foot Syndrome: A Case Report
Authors: Yella Sree Sudha Tanguturi , Uppala Praveen Kumar , Varghese Anjaly Mary , Velmurugan Hemasri , Thangaraju Pugazhenthan , Krishna Sasanka Kota Shesha Brahma Shree
Published: June 2022

Capecitabine, a prodrug of 5-fluorouracil, is an FDA-approved drug for adjuvant treatment
of colon, metastatic colorectal, and breast cancer. A variety of mucocutaneous adverse effects has been
recognized with capecitabine. The pathogenesis of such manifestations still remains an enigma though
various theories have been proposed. Here, we report two such cases. A 59-year-old female with carcinoma
of the sigmoid colon on palliative therapy developed localized cutaneous hyperpigmentation of
the palms and soles secondary to capecitabine in her 2nd cycle. Another case was of a 42-year-old female
with stomach adenocarcinoma, who developed similar adverse effects after administration of
capecitabine in her 4th cycle. Since these drugs have been widely used in recent years due to their relative
ease in administration, the relative unawareness of Hand-foot syndrome (HFS) caused due to this
drug makes it a prudent topic to be reported.