bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic variability and correlation studies in chickpea (Cicer arietinum L.)
Authors: Velpula Anil Kumar , Gaibriyal M. Lal
Published: April 2022

The present investigation on genetic variability and correlation studies in chickpea (Cicer arietinum L.) were carried out with 25 genotypes in a Randomized Block Design with three replications and observations were recorded on five randomly selected plants for 13 characters to study the amount of genetic variability, correlation, heritability at field experimentation center, department of genetics and plant breeding, Sam Higginbottom university of agriculture, technology and sciences, Prayagraj during Rabi-2019-2020. a detailed analysis of the results on per se performances revealed PHULE-G-5 followed by ICC-244263, RVG-202 and NEC-799, CSQ-512. Found superior for seed yield over the check (PUSA-362). Higher estimates of phenotypic and genotypic co-efficient of variation were observed for number of primary branches and number of pods per plant. High heritability was observed in number of primary branches number of seeds per plant. High genetic advance and genetic advance has percentage mean was observed in harvest index. High estimates of phenotypic correlation and genotypic correlation were recorded for test weight and biological yield per plant maximum positive direct effect were observed in test weight by biological yield, number of pods per plant and harvest index.
Study the difficulties encountered as well as obtain the suggestions from the SHGs members engaged in agriculture and allied enterprises
Authors: Nair R.G. , Kadam R.P. , Pawar G.S.
Published: April 2022

The present study was conducted purposively in Nanded and Parbhani districts of the Marathwada region of Maharashtra state during the year 2019-20 in jurisdiction of Mahila Arthic Vikas Mahamandal Organization (MAVIM) and district Rural Development Agency (DRDA) in Marathwada region of Maharashtra state as significant work done by both MAVIM and DRDA in the formation of SHGs. The main aim is to study the difficulties encountered by the SHGs members as well as obtain the suggestions from them who are engaged in agriculture and allied enterprises. The data related to participation in group activities showed that majority (70.95%) ‘Lack of regular participation of members’ which rank I, also the data related to running of the enterprises showed that ‘lack of training facilities nearby’ (92.38%) which rank I and majority cent per cent of the SHGs members were suggested that timely provision of financial support from banks which rank I.
Purchasing behavior of farmers towards hybrid watermelon seeds in North Gujarat
Authors: Henil M Chaudhari , Pundir R.S. , Nayak Archit Kumar
Published: April 2022

Over the last few years, farmers have become more aware of the benefits of utilising certified/quality seeds leading to increase in demand of seeds. Present study was conducted during 2018-19 in north Gujarat to examine the buying behaviour of farmers towards hybrid watermelon seeds. A multi-stage sampling design was employed for the study and required data were collected from 180 water melon farmers spread over 18 villages of 6 talukas, covering two watermelon growing districts namely Banskantha and Aravali. Primary data was collected using a structured questionnaire. Simple tools such as weighted mean average and Garrett ranking technique were employed to analyse the data. Finding indicates that the quality parameters of the seed like the yield, germination, disease resistance were the important factors influencing the purchase decision of the farmers regarding watermelon hybrid seeds. It was also observed that farmers were highly satisfied with the availability, price and better germination but raised concerns about the the yield aspect of the hybrid seed. The study pointed towards the need for progressive seed quality improvement by the private companies as well as regular capacity building for dealers to increase the awareness of using hybrid watermelon seeds.
Adoption of recommended pigeonpea production technology by the growers
Authors: Kale S. P. , Jakkawad S. R. , Akulwar S. R.
Published: April 2022

The study was conducted in purposively selected Jalna district of Marathwada region in Maharashtra state. From the selected district two talukas viz., Ambad and Badnapur were selected randomly as these talukas has considerable area under pigeonpea. Results of study revealed that majority (60.00%) of the farmers had medium level adoption of pigeonpea production technology while other 15 per cent of farmers belongs to high adoption level category pigeonpea production technology whereas, only 25.00 per cent of farmer belongs to low adoption level category of about pigeonpea crop.
The relationship between agricultural electricity consumption and GSDP in Maharashtra
Authors: Wani P. P. , Shende N. V. , Vaidkar R. D.
Published: April 2022

This study examined the casual relationship between agricultural energy consumption and agricultural growth in Maharashtra using annual data covering the period from 2009-10 to 2019. The study revealed that , there is no presence of the co integration equations at 0.005 per cent level of significance conformably denotes rejection of the hypothesis at the 0.05 level and showed none co integration equations were significant among agricultural growth GSDP and agricultural energy consumption EC. Applying a modified version of the Granger causality test it is found that there is uni-directional causality between agricultural energy consumption and agricultural growth in Maharashtra.
PERFORMANCE OF THE SAFER MODEL IN ESTIMATING ACTUAL EVAPOTRANSPIRATION OF WHEAT AND BEAN IRRIGATED CROPS IN THE CENTRAL BRAZILIAN SAVANNAH
Authors: LOPES JULIANA DIAS , RODRIGUES LINEU NEIVA , SCHERER-WARREN MORRIS , PAULA ADRIANO CÉSAR PEREIRA DE , FERREIRA THOMÁS ROCHA
Published: April 2022

Meeting the ever-growing demand for food depends tightly on irrigation. In this scenario, it is essential to manage the scarce water resources available and so to understand the spatial and temporal variation of actual evapotranspiration (ETa). In the past decades, models for monitoring and mapping ETa applying remote sensing data were developed and assessed. In this work, the performance of the Simple Algorithm for Evapotranspiration Retrieving (SAFER) for estimating the evapotranspiration of two annual winter irrigated crops in the Cerrado (Brazilians Savannah) was evaluated. Multispectral and thermal images from the sensors ETM+/Landsat 7 and OLI-TIRS/Landsat 8 were used for this purpose. Initially, the model was calibrated for the wheat crop, then this calibration was tested for the bean crop, using Bowen ration ETa data as reference. After calibration, a coefficient of determination (r2) equal to 0.91 and the root mean square error (RMSE) equal to 0.58 mm d-1 were found for the wheat. For the bean, the r2 was equal to 0.65 and RMSE, equal to 0.77 mm d-1. The results are satisfactory, although they suggest that the model may present an improved performance with specific calibration for each crop and/or region, or adopting calibration in two stages, for lower and higher NDVI values.
Narrativas de aborto na web: uma abordagem enativa acerca das alianças de gênero
Authors: Monteiro Talita Gonçalves , Maraschin Cleci
Published: April 2022

Resumo: O artigo discute relações de gênero com base nos estudos da enação no campo da cognição social. Para tal, utilizamos dois conceitos principais: a “ética do cuidado” e a “sororidade”. A partir da abordagem enativa, procuramos indícios de como algumas narrativas de aborto provocado apontam uma maneira ética de vivenciar os conflitos morais, protagonizada não só, mas, principalmente, por mulheres. Como campo empírico, escolhemos dois sítios da web: o site Women on Web e o tumblr da campanha desenvolvida pelo Instituto de Bioética Anis, com o nome de “Eu vou Contar”. A inspiração cartográfica foi utilizada para rastrear a maneira pela qual as narrativas compartilhadas apontam, movimentam e redesenham alianças de cuidado. Muitas narrativas de aborto problematizam uma ética universalista, apontando outras maneiras de vivenciar a reprodução e o aborto, indicando uma potência inventiva de viver as alianças de cuidado nas suas diferentes formas de manifestação.
Ascomycota in the litter of Inga edulis and Lafoensia pacari in an Atlantic Forest remnant in southeastern Bahia state, Brazil
Authors: Miranda Priscila Silva , Oliveira Thaiana Santos , Luz Edna Dora Martins Newman , Santos Maiara Araújo Lima dos , Bezerra José Luiz
Published: April 2022

Abstract The Ascomycota population in the litter of Inga edulis and Lafoensia pacari trees was identified and its richness was evaluated. The collections were carried out from October 2018 to July 2019. Twenty fallen leaves were collected in different stages of decomposition. The leaf samples were carefully washed in running water and incubated in humid chambers. The fungal structures were mounted in PVLG resin and observed under a light microscope. The identification was done by consulting the specific literature. Distribution studies included richness, frequency, constancy, and similarity of the fungal populations. The total richness was 48 species and 36 genera corresponding to 58.33% in I. edulis and 60.41% in L. pacari. Most taxa had sporadic frequency and accidental constancy. There was low similarity between plant species. Ascomycota populations are well represented in Inga edulis and Lafoensia pacari litter. Richness, frequency, constancy, and similarity of these populations varied little in function of the collection date, climate and host plant. Lower richness observed in the second collection may reflect the effect of reduced humidity observed in that time of the year.
Shiatsu-associated physical therapy on pain and fatigue on people with multiple sclerosis
Authors: Fillis Michelle Moreira Abujamra , Nicio Roseli , Nicio Roberto Toshio , Santos Gabriela Alves dos , Brandet João Marcos , Ribeiro Heloisa Galdino Gumieiro
Published: April 2022

Abstract Introduction: Pain and fatigue are common symptoms in multiple sclerosis (MS). Shiatsu, a technique that uses the pressure of fingers, associated with manual therapy, exercises and stretching can be used to control these symptoms. Objective: To evaluate the effect of Shiatsu associated with physical therapy on pain and fatigue on people with MS. Methods: Randomized clinical trial with people diagnosed with MS divided into two groups: intervention group (IG) - Shiatsu-associated physical therapy (n = 9), and control group (CG, n = 8). Participants were assessed before and after treatment by the Expanded Disability Status Scale (EDSS), Neuropathic Pain Questionnaire (DN4), Visual Analog Scale (VAS) and Fatigue Impact Scale (MFIS), and description of sociodemographic. Results: Seventeen people with MS (9 men) aged 45.18 ± 3.06 years participated in this study. In the total sample, the average of DN4 was 1.65 ± 20.02, VAS was 2.29 ± 2.80, MFIS was 39.47 ± 29.67, and 52.9 % had a score > 38 in the MFIS that corresponds to presence of fatigue. The values pre/post-intervention/grade of p, respectively in the IG were DN4: 2.78 ± 2.16/2.0 ± 2.12/0.432, EVA: 3.22 ± 3.27/0.33 ± 1.00/0.023, total MFIS: 44.44 ± 35.91/35 ± 31.70/0.068. In the CG the values were DN4 : 0.38 ± 0.744/2.25 ± 2.71/0.054, EVA : 1.25 ± 1.83/3.63 ± 2.38/0.043, and MFIS : 33.88 ± 21.68/25.13 ± 24.22/0.379. Conclusion: Shiatsu associated with Physiotherapy was effective in improving pain and fatigue in individuals with MS.
Um novo contrato motor nos domínios do esporte, lazer e Educação Física? Aportes para uma teoria reflexiva do movimento humano
Authors: Souza Juliano de , Oliveira Vinicius Machado de , Garcia Rui Proença
Published: April 2022

RESUMO Esse artigo teve como objetivo compreender em que medida as dinâmicas da modernização reflexiva concorreram para que um novo contrato motor emergisse nos contextos do lazer, esporte e Educação Física na contemporaneidade. Frente a esse desiderato, o texto foi estruturado em três seções. Na primeira parte, discutimos como a modernização reflexiva impactou as relações sociais num contexto macrossociológico. Em seguida, abordamos como e em que sentido as autobiografias de movimento foram alteradas na modernidade tardia. Por fim, introduzimos algumas bases para a uma teoria do movimento humano que se apeteça potencial na tradução dos novos sentidos atribuídos ao lazer e ao esporte na sociedade contemporânea.
Effects of solid fraction of saturated granular flows on overflow and landing mechanisms of rigid barriers
Authors: Ng Charles W. W. , Majeed Usman , Choi Clarence E.
Published: April 2022

Steep creek hazards are characterised according to their solid fraction, νs, which governs the flow dynamics. To arrest these hazards, rigid multiple barriers are installed along a channel. However, existing design guidelines are deficient because the fundamental overflow and landing mechanisms are not well understood. In this study, experiments were conducted using a 5 m long flume to model the impact of flows with different νs values on a rigid barrier. By varying the νs of sand–water mixtures, the dynamics of different steep creek hazards were modelled. The barrier height was varied to obtain barrier Froude numbers Frb (ratio of flow inertia to potential energy related to barrier height) from 0·7 to 3·4. Results show that barriers should be designed so that Frb < 1, which leads to downward overflow with reduced landing distances. In addition, the landing distance for the watery flows (νs = 0 to 0·1) is up to 87% longer than that of dry granular flows. This implies that the design spacing between barriers should cater for different types of steep creek hazards and Frb. An existing framework for multiple barriers is modified to provide guidance on the selection of the barrier height using the Frb.
Complete stress–strain curves of reactive powder concrete reinforced with basalt fibres
Authors: Sha Haiyang , Liu Jinchun
Published: April 2022

The compressive stress–strain curves of reactive powder concrete (RPC) reinforced with basalt fibres (BFs) were experimentally studied. The length and volume content of BFs were considered as the influencing parameters. A total of 15 groups of cementitious composite specimens were investigated. The workability, failure mode, peak stress, corresponding strain at peak stress, elastic modulus, toughness index and stress–strain curve of the cement-based composites were carefully explained. The results indicated that an increase in fibre volume content gradually decreased the workability of the specimen. Specimens reinforced with 6 mm and 12 mm long BFs showed different failure modes from those reinforced with 18 mm BFs. The former had better integrity, while the latter had poor integrity. The shorter BFs (6 mm and 12 mm) improved the performance under peak stress and the compressive toughness of the RPC. For the 18 mm long BFs, with increasing fibre content, the peak stress and the corresponding strain decreased and the toughness index also decreased gradually. The fibre length/content had a small effect on the elastic modulus of the RPC but, with increasing fibre volume content, the peak secant modulus of the specimens decreased gradually. Considering the results of four groups of models, a group of predictive models was selected to express the complete stress–strain curves of RPCs reinforced with BFs.
Att kontextualisera det oartikulerade: Om vargar och hur vi lyssnar till dem
Authors: Dirke Karin
Published: April 2022

The theoretical discussions within human-animal studies provide us with the incentive to ascribe agency to animals. The problem is finding adequate methods to do so, especially within history. Animals neither speak nor write, and the traces they leave in historical sources are scarce and difficult to understand. We need to consult knowledge from other fields, such as zoology and ethology, and actively use an interdisciplinary approach, in order to access information about animals in history. However, the question remains how it is possible for the historian to interpret agency which is not articulated in the sources. Using a small nineteenth-century news item about a wolf as example, I demonstrate how much information can be extracted when the source is read against various backgrounds. In the chapter I argue that by contextualizing sources creatively and not interpreting them in a prefixed way, the historian can approach animal agency in history. I discuss how different ways of contextualizing change the interpretation and thereby suggest a method to access animal agency in historical sources.
Variation in stem-final consonant clusters in Korean nominal inflection
Authors: Kim Ji Yea
Published: April 2022

This study investigates how Korean stem-final consonant clusters /ps/, /ks/, /lp/, /lk/, /ls/, and /lm/ exhibit variation, when a vowel-initial inflectional suffix is attached to noun stems. It is well-established that the Korean stem-final consonant clusters are either fully faithfully preserved (i.e. conservative), or simplified by deleting one of the two consonantal elements C1 and C2 (i.e. innovative). However, there has been no study about dominant patterns across clusters: which consonant cluster is more prone to preservation or simplification when inflected. When it comes to simplification, it has also been unclear which of C1 or C2 undergoes deletion, and why. Results of a production experiment show that there is a stark dichotomy between the clusters that share the same [±sonorant] feature (/ps/, /ks/, /lm/) and those that do not (/lp/, /lk/, /ls/): the former preferred conservative forms, whereas the latter favored innovative forms. Innovative forms in particular are accounted for in relation to consonant cluster simplification in isolation forms of nouns, following Kenstowicz’s (1996) Base-Identity effect. While the nature of the consonant cluster turned out to be a significant factor for variation in inflected forms, other factors (inflectional suffixes, speakers’ regional dialects, and gender) did not. This study is significant, in that it sheds light on a blind spot in the discussions of variation in stem-final consonant clusters in Korean and provides a comprehensive analysis that connects consonant cluster simplification in isolation forms with conservative/innovative forms in inflected forms. 
The at-issue status of ideophones in German: An experimental approach
Authors: Barnes Kathryn Rose , Ebert Cornelia , Hörnig Robin , Stender Theresa
Published: April 2022

Formal linguistics generally assumes that form-meaning relations in spoken language are arbitrary and not iconic. Ideophones, such as the English splish-splash have been considered exceptions to this rule of arbitrariness. Recently, however, researchers have begun to examine iconicity in spoken language more closely. Following work which established the default not- at-issue status of iconic co-speech gestures, here we discuss the crosslinguistic evidence for the (not-)at-issueness of ideophones and the factors that may have an influence upon this. We also present what we believe to be the first experimental work on the at-issue status of ideophones, conducted with German speakers. Although German may not be a prototypical ideophonic language, we argue that German ideophones follow crosslinguistic patterns in terms of at-issueness and provide initial evidence for the not-at-issue status of sentence- medial adverbial ideophones in German. This evidence comes from sentence-context matching tasks, where the mismatch effect was significantly larger for sentences containing standard adverbials than those containing sentence-medial adverbial ideophones. We presume that speaker judgements concerning how well target sentences match discourse contexts should be more impaired by mismatches induced by material relevant to the Question Under Discussion (QUD), i.e. at-issue material, than those induced by material irrelevant to the QUD, i.e. not-at- issue material. We thus argue that speakers’ ratings indicate that sentence-medial adverbial ideophones in German are not at-issue. This paper suggests a starting point for investigating the pragmatic status of ideophones crosslinguistically and also allows for comparison to previous research on other iconic enrichments, in particular gestures. This then has implications for our understanding of the at-issue status of iconic enrichments and how these enrichments interact with each other.
Prominence marking in an edge-prominent language - the case of Drehu
Authors: Torres Catalina , Fletcher Janet
Published: April 2022

This study investigates prosodic correlates of phrasing in Drehu, an Oceanic language from New Caledonia. The analysis is concerned with the demarcation of prosodic levels in the language, namely the Accentual Phrase and the Intonation Phrase. First impressionistic descriptions of Drehu state there is fixed word initial stress, however recent experimental evidence does not support this claim. Instead, it has been suggested that Drehu could be an edge-marking language which relies on right boundary marking. To determine whether the patterns recorded in the literature are borne out, the phonological and phonetic realisation of post-lexical word level prosody is investigated. An experiment was conducted to examine the extent to which fundamental frequency (F0) and duration contribute to boundary marking in Drehu. The results show that F0 cues mark the right boundary of two prosodic levels, the AP and IP, and that the strength of the boundary is related to its level in the prosodic hierarchy. Preboundary lengthening also cues IP boundaries but not AP boundaries.
Features of ﬂuid dynamics in long-term heterogeneous gas reservoirs
Authors: Feyzullayev A. A. , Gojayev A. G. , Mamedova I. M.
Published: April 2022

Geological features are characterized by macro- and micro-heterogeneity, manifested by the spatial variability of material composition and lithophysical properties of rocks. This, in turn, determines the spatial and temporal variability of hydrocarbon (HC) ﬂuid dynamics both during the reservoir formation and during its development and, subsequent operation as an underground gas storage facility (UGSF). The long-term operation of underground gas reservoirs at the Galmas and Garadagh areas in the South Caspian Basin (SCB), serving as a reservoir of commercial gas accumulations, and subsequent underground gas storage (UGSF) is characterized by signiﬁcant peculiarities. Analysis of monitoring data on volumes of gas injection and extraction at the Galmas/Garadagh UGSF in the period of 2020–2021 showed their spatial variability, as well as the variability of wells deliverability during the gas reservoir development. This suggests the inherited nature of UGSF operation mode in relation to the gas reservoir development mode. The heterogeneous nature of spatial variability of these parameters is determined by the reservoir rock poroperm properties. A formation pressure drop during reservoir development is accompanied by decreasing rock permeability. When operating UGSF, the lithofacial properties of rocks determine the ratio of volumes of injected and extracted gas. In this regard, a necessary condition for selecting the optimal system of UGSF operation is to take into account the spatial heterogeneity of the underground reservoir. The irregular nature of variation of rock poroperm properties, the origination of isolated zones in the reservoir with considerable residual gas volumes, as well as unpredictable directions of ﬂuid movement are the main reasons for decreased efﬁciency of ﬁeld development and underground gas storage facility operation. In order to determine the optimal system of operation of UGSF in depleted underground oil and gas reservoirs, the features of the spacial variations resulting from the rocks poroperm properties need to be taken into account.
[RETRACTED] MediCramp 9 Best Things About : (Thigh Cramps) Fake Or Trusted! v1
Authors: not provided medicramp
Published: April 2022

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MediCramp MediCramp – Official Website Link – Click Here Come to know about the MediCramp formula that ought to be containing only magnesium, the formula is really a surprising one that delivers 4 different types of natural ingredients all of which share maximum efficacy in reducing the duration, frequency, and intensity of cramps.
Highly Parallel Droplet Sample Preparation for Single Cell Proteomics v2
Authors: Leduc Andrew , Huffman Richard , Khan Saad , Slavov Nikolai
Published: April 2022

Protocol for preparing single cells for mass-spec analysis by nPOP as described by Leduc et al., 2021, 2022 DOI: 10.1101/2021.04.24.441211. nPOP uses piezo acoustic dispensing to isolate individual cells in 300 picoliter volumes and performs all subsequent preparation steps in small droplets on a fluorocarbon-coated slide. This design enables simultaneous sample preparation of thousands of single cells in a single batch. This includes lysing, digesting, and labeling individual cells in volumes below 20 nl. nPOP supports different experimental designs including label free analysis, TMT 18plex with carrier, mTRAQ, and TMT-10plex for TOF instruments (see steps). Data, resources and additional information: https://scp.slavovlab.net/Leduc_et_al_2022 and https://scp.slavovlab.net/nPOP Andrew Leduc presented a detailed workflow of nPOP at the 4th Single Cell Proteomics Conference available on YouTube: https://youtu.be/DJ1U_KpMNcY The protocol uses the CellenONE system for liquid handling and cell sorting and assumes basic level of familiarity and training on the CellenONE. If there are any questions, please email leduc.an@northeastern.edu
[RETRACTED] K2 Keto Drops Review - Urgent Shocking Details Revealed Inside v1
Authors: not provided kketo
Published: April 2022

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[RETRACTED] fit form keto v1
Authors: Keto buyregalketo
Published: April 2022

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[RETRACTED] Nucentix Keto X3 v1
Authors: not provided nucentixde
Published: April 2022

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Nucentix Keto X3
[RETRACTED] GEMINI KETO GUMMIES REVIEWS – DOES IT REALLY WORK? v1
Authors: Keto Gummies TrimLab
Published: April 2022

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Availability of Open Citations from Open Journals in Crossref v1
Authors: Brembilla Davide , Catizone Chiara , Venditti Giulia
Published: April 2022

This protocol is for the research about the availability of Open Citations from Open Journals in Crossref. The goal is to find out how many papers from DOAJ journals are available on Crossref, whether their metadata is available and the origin of their DOI. Our research involves the articles from Open Access journals in DOAJ and their data on Crossref. We scouted the availability of these articles’ reference lists, the presence of IDs such as DOIs and the entities responsible for their specification. This analysis was carried out by querying the DOAJ and Crossref’s APIs, creating datasets combining the two. The data will be further analysed to verify the distribution of the provenance of the articles' DOI.
[RETRACTED] GoKeto Gummies Reviews - How Go Keto Gummies Works? v1
Authors: not provided goketogummiesreviewsorks
Published: April 2022

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GoKeto Gummies Reviews - How Go Keto Gummies Works?
[RETRACTED] Younabis CBD Gummies - Editor's Choice Overall Best Gummies for Pain & Inflammation With Turmeric Benefits v1
Authors: CBD Gummies Younabis
Published: April 2022

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Younabis CBD Gummies - Editor's Choice Overall Best Gummies for Pain & Inflammation With Turmeric Benefits
Transition from first illegal drug use to first injection among people who inject drugs in Northern Mexico: A retrospective survival analysis
Authors: Ospina-Escobar Angélica , Magis-Rodríguez Carlos
Published: April 2022

Introduction. There is little information in Mexico about the transition to injecting drugs among drug users in cities other than Tijuana. Objective. We compare characteristics of the onset of drug use and first injection among people who inject drugs (PWID) from Ciudad Juárez and Hermosillo, two cities of Northern Mexico and identify factors associated with faster rates of transition from first drug use to the first injection. Method. 841 PWID were interviewed in 2012 in Ciudad Juárez (n = 445) and Hermosillo (n = 396). Using lifetables, we describe timing at the onset of drug use and first injection. Cox regression analysis was used to determine factors associated with the transition hazard to first injection. Results. Median age at onset of drug use was 15.5 years old (standard deviation [SD] = 5.73). The median age at first injection was 21.30 (SD = 7.22). The median duration-time between first drug use and transition to injection was 4.8 years (SD = 5.6). Controlling for sociodemographics, factors that increase the hazard of transitioning to injection are age at onset of drug use (adjusted-hazard-rate [AHR] = 1.04, 95% confidence-interval CI [1.03, 1.05], p#abr#.01) having used cocaine, heroin, or methamphetamine at the onset of drug use (AHR = 1.14, 95% CI [1.03, 1.27], p = .01), and having received assistance at first injection (AHR = 1.25, 95% CI [1.17, 1.33], p#abr#.01). Discussion and conclusion. Results show the need to enhance harm reduction programs among non-injecting drug users so as to prevent the spread of injecting drugs in Mexico.
Культура как необходимая роскошь: сопоставление пяти характеристик тезауруса с чертами субъектно-этической эпистемологии Э. Левинаса
Authors: Куминова Ольга Леонидовна
Published: April 2022

Данная статья представляет собой исправленный и дополненный текст доклада на организованных Московским гуманитарным университетом IV Академических чтениях памяти Валерия и Владимира Луковых на тему «Тезаурусы и проблемы культуры» (27 мая 2021 г.).

Автор проводит параллели между пятью характеристиками тезауруса — полнотой, существенностью, систематичностью, ориентирующим назначением и избыточностью — и чертами отношения к Другому, в котором конституируется субъект в философии Эмманюэля Левинаса, прежде всего в его magnum opus «Тотальность и бесконечное».

Хотя основным предметом исследования в этом труде является субъектно-ориентированная онтология и метафизика, Левинас ставит в центр самого человеческого бытия язык и речь как основополагающую для субъекта этическую позицию лицом к лицу с Другим. Помещение этой этической и языковой конфигурации в центр бытия имеет радикальные последствия для того, как устроено знание субъекта о мире. Это знание не может быть тотальным, всеобъемлющим даже теоретически, и феноменология познания, которую создает Левинас в этой системе, во многом перекликается с теорией тезаурусов братьев Луковых.
Молодежная политика через призму научных взглядов Вал. А. Лукова
Authors: Михайлова Екатерина Олеговна
Published: April 2022

В статье рассмотрен подход Вал. А. Лукова к пониманию сущности молодежной политики, выстроенный на тезаурусной концепции молодежи. Данный подход строится на трех концептуальных положениях: о неоднородности молодежи как социально-демографической группы, единстве государственной и общественной молодежной политики и конструировании человека посредством воспитания.
Intraoperative Finding of a Patient with Uterine Fibroid
Authors: Baklygina Elena A. , Pchelintsev Vadim V. , Pristupa Eugeniya M. , Verkina Elena N.
Published: April 2022

INTRODUCTION: Most neoplasms in the pelvic cavity of women arise from organs of the reproductive system. However, diseases of the gastrointestinal and urinary tracts and neoplasms of a neurogenic and primary extraperitoneal nature can be also encountered in the pelvis where they may be mistaken as gynecological pathology. Thus, in an intraoperative discovery of previously undiagnosed foci of tumor lesions the surgical approach has to be changed, which can negatively affect the results of surgical treatment. Gastrointestinal stromal tumors (GISTs) refer to the most common tumors of the gastrointestinal tract originating from the mesenchymal anlage. Up to 70% of GISTs are located in the stomach, 20%40% in the duodenum and small intestine, 5%15% in the colon, and 2%5% in the esophagus, with single tumors occurring in the appendix.
CONCLUSION: The article presents a clinical case of a patient who underwent hysterectomy for multiple uterine fibroids and in whom a large GIST of the sigmoid colon was found intraoperatively that was previously mistaken as one of the subserous nodes of uterine fibroids.
Clinical Manifestations and Diagnosis of Pulmonary Embolism in Routine Clinical Practice: Data from the Ryazan Regional Vascular Center
Authors: Yakushin Sergey S. , Nikulina Natal’ya N. , Terekhovskaya Yuliya V.
Published: April 2022

BACKGROUND: Data on the peculiarities of the clinical presentation and characteristics of pulmonary embolism (PE) and problems of its diagnosis in routine clinical practice (CP) are limited. Data obtained long ago are mostly described in terms of venous thromboembolism in general and practically do not include Russian patients with PE. The study was performed within the RusSIan REgistery of pulmoNAry embolism (SIRENA) register.
AIM: To study the peculiarities of the clinical and demographic profile and diagnosis of PE in modern CP in comparison with the results of other PE registers.
MATERIALS AND METHODS: In this registry-based study, medical records were analyzed to obtain information on the demographic profile, clinical presentation, and examination results of patients with PE (n = 107; age, 63 (5274) years; men, 39.3%) who received inpatient treatment in one of the Ryazan Regional Vascular centers. The study period was 13 months (20182019).
RESULTS: The most common concomitant pathologies were arterial hypertension (70.1%), obesity (46.7%), and diabetes mellitus (17.8%). High- and moderate-risk factors were identified in 26.2% and 72.9% of the patients, respectively. Low-risk factors identified in 5.6% of the patients in different combinations did not have a single risk factor for PE development. Clinical manifestations included shortness of breath (93.5%), chest pain (43.0%), severe weakness (59.8%), tachycardia (29.0%), hypoxemia (27.1%), and unstable hemodynamics (18.7%). The most frequent electrocardiographic sign was a T-wave inversion in the right chest leads (52.3%). Right ventricle dysfunction was detected in 38.1% of the cases and elevation of troponin levels in 33.6%. According to the Pulmonary Embolism Severity Index scale, high- and very-high-risk cases accounted for 46.7% of the cases. According to the results of the integrated assessment of PE severity, 34.6% and 14.0% of the patients moved to the lower- and higher-risk classes, respectively. The proportion of moderate-risk cases increased from 23.4% to 62.6%, and the high- and very-high-risk cases reduced from 46.7% to 32.0%.
CONCLUSION: The modern clinical picture of PE is characterized by a higher prevalence of concomitant pathology and reduction of the rates of traditional risk factors. There remain difficulties in PE diagnosis, which are associated with the concomitant pathology, absence of traditional risk factors, and non-specificity of the clinical manifestations and results of additional examinations.
Minimally invasive treatment of pilonidal cysts in children: the Gips procedure
Authors: Stepanova Nataliya M. , Novozhilov Vladimir A. , Mochalov Mikhail N. , Zvonkov Denis A. , Voropaeva Anastasia V. , Petrov Evgeniy M. , Moroz Sergey V. , Khaltanova Dora Yu. , Namkhanov Vyacheslav V.
Published: April 2022

BACKGROUND: Pilonidal disease (pilonidal cyst, epithelial coccygeal passage) is a chronic inflammatory disease of the sacrococcygeal region, common among young people, including adolescents, to a certain extent worsens the quality of life. Until now, the etiopathogenesis and surgical treatment methods of the disease have been the subject of wide discussion.
AIM: The aim of the study was to evaluate the effectiveness of Gips operations in children with pilonidal disease.
MATERIALS AND METHODS: A comparative analysis of 41 patients with pilonidal disease was conducted in the surgical department of the City Ivano-Matryoninsk Children's Clinical Hospital in Irkutsk from January 2020 to August 2021. Planned surgical treatment was performed in 22 patients with primary or recurrent pilonidal cysts, including 15 children using the M. Gips procedure. The comparison group consisted of patients who underwent wide excision of a complex of soft tissues bearing a pilonidal cyst, primary and secondary fistulous passages, followed by wound restoration with a storey suture.
RESULTS: The patients comprised 72.7% boys and 27.3% girls with an average age of 15.6 1.5 years and average disease duration of 5.1 2.2 months. The average operation time was 12 4.2 minutes. The motor regime was resumed on the first day after the operation. Patient pain was relieved by administering non-steroidal anti-inflammatory drugs for the first two postoperative days. There were no early postoperative complications. The average hospital stay was 3.8 1.9 days. Complete healing by secondary intention was achieved after an average of 3.9 1.8 weeks. The average follow-up was 7 3.8 months, and 6.7% had early relapses.
CONCLUSIONS: Minimally invasive sinusectomy according to the Gips procedure for treating pilonidal disease in adolescents is safe and effective, has a low recurrence rate, allows an early return to daily activities, and provides a good cosmetic result. However, the small number of observations requires further research.
Anesthetic management of a repeatedly operated patient with extrahepatic portal hypertension: Сase report
Authors: Naleev Aleksey A. , Lazarev Vladimir V. , Linkova Tatiana V. , Tsypin Leonid  E.
Published: April 2022

BACKGROUND: The use of high doses of opioids and general anesthetics can cause unwanted side effects that directly affect the patient's recovery and his psycho-emotional and social well-being. In this regard, the general anesthesia method enables the dose reduction of general anesthetics and opioid analgesics. This is relevant, especially in children with concomitant thrombocytopenia, in whom epidural blockade is contraindicated.
CASE REPORT: This article describes using the alpha-2-adrenergic agonist, dexmedetomidine, for anesthesia in a 16-year-old girl during corrective surgery for extrahepatic portal hypertension after several previous operations. Using the selective alpha-2-adrenergic agonist, dexmedetomidine, for general anesthesia produced effective and stable pain relief intraoperatively and rapid recovery of spontaneous breathing and consciousness after anesthesia. The total dose of intraoperative consumption of fentanyl compared with previously performed anesthesia was less than two times, and sevoflurane by 30%, while maintaining adequate anesthetic protection.
CONCLUSION: During surgical interventions, it is impossible to perform epidural anesthesia in patients with thrombocytopenia with extrahepatic portal hypertension. The centrally acting alpha-2-agonist, dexmedetomidine, may be used to reduce the doses of anesthetics and opioid analgesics used.
Risks and Threats of Total Digitalization: Opportunity and Manageability Level
Authors: Timchenko Anastasia V.
Published: April 2022

This article deals with societys different spheres and parts of the economys total digitalization, particularly in the transportation security sphere. Although artificial Intelligence carries multiple process-simplifying innovations, it possesses numerous hidden threats and risks in digital technology transformation. Chinas social credit system experience that carried out global digital technologies is analyzed. Digitalization is a method employed to transform managerial and legal decisions into the digital field. Modern humans should find their position in this digital space.
Toxic retinopathy and optic neuropathy in long-term tacrolimus intake
Authors: Denisova Ekaterina V. , Myshko Ilya V. , Ivanova Margarita S.
Published: April 2022

Tacrolimus is an effective immunosuppressive agent that is widely used in transplant surgery. Rare complications of its usage include optic neuropathy or maculopathy development.
AIM: To present a clinical case of tacrolimus-induced optic neuropathy and retinopathy
CLINICAL CASE. A family with a 17-year-old boy was referred to Helmoltz National Medical Research Center of Eye Diseases with complaints of sudden painless decreased vision in his right eye. The best-corrected visual acuity was the right eye of 0.3 and the left eye of 1.0. Ophthalmoscopy of his right eye revealed pigment mottling in the macula and paramacular region, mid-peripheral patchy pigment deposition in 2, 4, and 8 clock meridians. No pathological findings were revealed in his fellow eye. From the anamnesis, 15 years ago, the patient underwent liver transplantation (Alagille syndrome). From the moment of surgery to the date he received tacrolimus. Optical coherence tomography highlighted foveal smoothing, ellipsoid zone and retinal pigment epithelium disruption, macular and paramacular choroid thinning, and neuroretinal rim thickening. Computed microperimetry revealed a significantly decreased sensitivity in the central retinal zone of the right eye. Autofluorescence examination showed multiple punctate hypoautofluorescent spots in the macula and paramacula in the right eye, as well as hyperautofluorescent zones in the posterior pole in both eyes. Electric activity analysis has revealed decreased full-field electroretinogram parameters and P100 amplitude in visually-evoked potentials in the right eye and a decreased a-wave full-field electroretinogram of the left eye. The data provided by the parents suggest that the target tacrolimus concentration in plasma was exceeded 2 times just before the patient noticed vision impairment. Differential diagnoses included infectious and non-infectious posterior uveitis.
CONCLUSION: The first case of combined retinopathy and optic neuropathy in adolescents induced by long-term tacrolimus treatment was described.
Efficacy of non‑platinum chemotherapy in platinum‑resistant ovarian cancer: a meta‑analysis
Authors: Rumyantsev A. A. , Tyulyandina A. S. , Israelyan E. R. , Pokataev I. A. , Fedyanin M. Yu. , Glazkova E. V. , Sergeev Yu. S. , Tjulandin S. A.
Published: April 2022

Background: Recurrent ovarian cancer (OC) patients with platinum‑free interval (PFI) < 6 mo. are usually considered platinum‑resistant and treated with non‑platinum based chemotherapy. There is a lack of evidence to compare various non‑platinum therapeutic options in patients with platinum‑resistant ovarian cancer (PROC). We conducted meta‑analysis to assess efficacy of various therapeutic options in PROC patients. This article aimed to compare non‑platinum therapeutic regimens.

Methods: We queried the PubMed database for full‑text articles and abstracts on the treatment of PROC patients (01/01/2000–01/06/2019 timeframe). Inclusion criteria were: 1) epithelial ovarian cancer; 2) recurrent disease ≤ 6 mo. after platinum‑based chemotherapy; 3) standard therapy with platinum‑ or non‑platinum agents; 4) no targeted therapy, investigational agents or non‑platinum doublets; 5) reported response rate (RR) and assessment criteria. Proportion meta‑analysis (random‑effect model) and beta‑regression were conducted to assess efficacy of various options. Statistical analysis was dose with meta and betareg packages of R software.

Results: We identified 7156 articles and screened them for title and abstract, 157 studies were left for further analysis. Efficacy of non‑platinum‑ and platinum‑based therapy was assessed in 113 (n = 5272) and 44 (n = 1055) trials respectively, only the latter were included in this analysis. In meta‑proportion random‑ effect model RR among patients treated with taxanes, etoposide, doxorubicin/PLD, topotecan and gemcitabine were 27 % (95 % CI 0.21–0.34), 19 % (95 % ДИ 0.13–0.27), 15 % (95 % CI 0.11–0.19), 13 % (95 % CI 0.10–0.18) and 10 % (95 % CI 0.07–0.14), respectively. Multiple beta‑regression model accounting for response assessment method, number of prior therapy lines and other factors confirmed the results.

Conclusions: Taxanes monotherapy may be the most effective therapeutic option for patients who are not candidates for platinum‑based chemotherapy.
Formation of New Life Strategies of the Nomadic Kazakhs the Imperial Frontier of the 19th — Early 20th Century
Authors: Kovalskaya Svetlana
Published: April 2022

The article will analyze the process of the formation of new, different from traditional, life strategies of Kazakh nomads of the imperial frontier zone of the 19th — early 20th centuries based on the analysis of various sources, as well as works and studies devoted to characterizing the specifics of the existence of nomadic forms of management. We studied materials 175 of the Fund of the State Archive of the Orenburg Region, as well as Temporary Provisions on Management in the Steppe Regions of the Orenburg and West Siberian Governor-Generals and Materials on Kyrgyz Land Use published from 1896 to 1915. In addition, certain works of Kazakh literature were drawn, which are unique historical sources. The article is based on the analysis of various historical sources, as well as works and studies devoted to the characteristics of the existence of nomadic forms of management and formation the new types of life strategy. A critical approach to various historical sources allowed us to compare the diverse factual material, reconstruct the transformation, and change in the self-awareness of yesterday's nomads Nomads maximally inscribed in nature and the surrounding landscape retained their identity through the realization of a pastoral way of life and mentality. The gradual, ever more active manifestation of the new logic of development proposed by the Russian Empire, which is alien to nomads, made the Kazakhs develop new mechanisms for survival and self-realization in the proposed circumstances, adapting to them as much as possible. The Kazakh elite of the turn of the 19th — 20th centuries tried to give answers to the classical questions of the intelligentsia: who is to blame and what to do? It was necessary to determine in the further perspective of life: to preserve nomadism, to seek other substitute forms of semi-nomadic forms, or gradually to move to a sedentary life. The specificity of the frontier territory was manifested in the fact that nomadic Kazakhs were actively involved in the process of transforming everyday life and, in order to protect their lands from increasing competition of peasants, learned to rely not only on their own resources, but also to find support in local authorities.