bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding and Therapeutic Application of Immune Response in Major Histocompatibility Complex (MHC) Diversity Using Multimodal Artificial Intelligence
Authors: Matsuzaka Yasunari , Yashiro Ryu
Published: August 2024

Human Leukocyte Antigen (HLA) is like a device that monitors the internal environment of the body. T lymphocytes immediately recognize the HLA molecules that are expressed on the surface of the cells of the different individual, attacking it defeats microorganisms that is one of the causes of rejection in organ transplants performed between people with unmatched HLA types. Over 2850 and 3580 different polymorphisms have been reported for HLA-A and HLA-B respectively, around the world. HLA genes are associated with the risk of developing a variety of diseases, including autoimmune diseases, and play an important role in pathological conditions. By using a deep learning method called multi-task learning to simultaneously predict the gene sequences of multiple HLA genes, it is possible to improve accuracy and shorten execution time. Some new systems use a model called convolutional neural network (CNNs) in deep learning, which uses neural networks consisting of many layers and can learn complex correlations between SNP information and HLA gene sequences based on reference data for HLA imputation, which serves as training data. The learned model can output predicted values of HLA gene sequences with high accuracy using SNP information as input. To investigate which part of the input information surrounding the HLA gene is used to make learning predictions, predictions were made using not only a small number of nearby SNP information but also many SNP information distributed over a wider area by visualizing the learning information of the model. While conventional methods are strong at learning using nearly SNP information and not good at learning using SNP information located at distant locations, some new systems are thought that prediction accuracy may have improved because this problem was overcome. HLA genes are involved in the onset of a variety of diseases and are attracting attention. As an important area from the perspective of elucidating pathological conditions and realizing personalized medicine. The applied multi-task learning to two different HLA imputation reference panels—a Japanese panel (n = 1118) and type I diabetes genetics consortium panel (n = 5122). Through 10-fold cross-validation on these panels, the multi-task learning achieved higher imputation accuracy than conventional methods, especially for imputing low-frequency and rare HLA alleles. The increased prediction accuracy of HLA gene sequences is expected to increase the reliability of HLA analysis, including integrated analysis between different racial populations, and is expected to greatly contribute to the identification of HLA gene sequences associated with diseases and further elucidation of pathological conditions.
Opinion: Applications of and Barriers to the Use of Biomimicry towards a Sustainable Architectural, Engineering and Construction Industry Based on Interviews from Experts and Practitioners in the Field
Authors: Jones Rory V. , Fuertes Alba , Scherer Roman , Clements-Croome Derek
Published: August 2024

Biomimicry creates designs inspired by nature and uses ecological benchmarks to assess their sustainability. It is believed that biomimicry can help society produce and consume in more sustainable ways, as well as address some of the key challenges facing the world today. However, research into the applications of and possible barriers to using biomimicry for creating more sustainable Architectural, Engineering and Construction (AEC) projects is still limited. This paper addresses this gap by undertaking and analysing twelve semi-structured interviews with leading global experts and practitioners in the field of biomimicry as applied to the built environment industry. The study identifies substantial potential in the use of biomimicry in AEC projects, including the following: adopting circular approaches; enhancing interactions between human and natural infrastructure; optimising material and energy use; recycling and re-use of materials; reducing time and costs; plus more collaborative and interdisciplinary working. However, a wide range of multifaceted barriers also exist that are currently hindering the exploration and exploitation of this potential, including the following: lack of knowledge; insufficient research and testing at the scale of AEC projects; fragmentation, poor communication and traditional nature of the industry; perception of high risks and costs; as well as outdated and unsuitable legislation and planning processes.
Towards Design Optimization of Compliant Mechanisms: A Hybrid Pseudo-Rigid-Body Model–Finite Element Method Approach and an Accurate Empirical Compliance Equation for Circular Flexure Hinges
Authors: Kabganian Masoud , Hashemi Seyed M.
Published: August 2024

Innovative designs such as morphing wings and terrain adaptive landing systems are examples of biomimicry and innovations inspired by nature, which are actively being investigated by aerospace designers. Morphing wing designs based on Variable Geometry Truss Manipulators (VGTMs) and articulated helicopter robotic landing gear (RLG) have drawn a great deal of attention from industry. Compliant mechanisms have become increasingly popular due to their advantages over conventional rigid-body systems, and the research team led by the second author at Toronto Metropolitan University (TMU) has set their long-term goal to be exploiting these systems in the above aerospace applications. To gain a deeper insight into the design and optimization of compliant mechanisms and their potential application as alternatives to VGTM and RLG systems, this study conducted a thorough analysis of the design of flexible hinges, and single-, four-, and multi-bar configurations as a part of more complex, flexible mechanisms. The investigation highlighted the flexibility and compliance of mechanisms incorporating circular flexure hinges (CFHs), showcasing their capacity to withstand forces and moments. Despite a discrepancy between the results obtained from previously published Pseudo-Rigid-Body Model (PRBM) equations and FEM-based analyses, the mechanisms exhibited predictable linear behavior and acceptable fatigue testing results, affirming their suitability for diverse applications. While including additional linkages perpendicular to the applied force direction in a compliant mechanism with N vertical linkages led to improved factors of safety, the associated increase in system weight necessitates careful consideration. It is shown herein that, in this case, adding one vertical bar increased the safety factor by 100N percent. The present study also addressed solutions for the precise modeling of CFHs through the derivation of an empirical polynomial torsional stiffness/compliance equation related to geometric dimensions and material properties. The effectiveness of the presented empirical polynomial compliance equation was validated against FEA results, revealing a generally accurate prediction with an average error of 1.74%. It is expected that the present investigation will open new avenues to higher precision in the design of CFHs, ensuring reliability and efficiency in various practical applications, and enhancing the optimization design of compliant mechanisms comprised of such hinges. A specific focus was put on ABS plastic and aluminum alloy 7075, as they are the materials of choice for non-load-bearing and load-bearing structural components, respectively.
Early Boost of Linguistic Skills? Individualized Non-Invasive Brain Stimulation in Early Postacute Aphasia
Authors: Rubi-Fessen Ilona , Gerbershagen Kathrin , Stenneken Prisca , Willmes Klaus
Published: August 2024

Non-invasive brain stimulation, such as transcranial direct current stimulation (tDCS), has been shown to increase the outcome of speech and language therapy (SLT) in chronic aphasia. Only a few studies have investigated the effect of add-on tDCS on SLT in the early stage of aphasia; this may be due to methodological reasons, in particular the influence of spontaneous remission and the difficulty of establishing stimulation protocols in clinical routines. Thirty-seven participants with subacute aphasia (PwA) after stroke (23 men, 14 women; mean age 62 ± 12 years; mean duration 49 ± 28 days) were included in two consecutive periods of treatment lasting two weeks each. During the first period (P1) the participants received 10 sessions of SLT, during the second period (P2) the aphasia therapy was supplemented by anodal left hemispheric 2 mA tDCS over the left hemisphere. Severity-specific language tests (Aachen Aphasia Test (AAT), n = 27 and Bielefeld Aphasia Screening-Reha (BIAS-R), n = 10) were administered before P1, between P1 and P2, and after P2. Where information was available, the results were corrected for spontaneous remission (AAT sample), and the therapy outcomes of P1 and P2 were compared. Participants’ overall language abilities improved significantly during P1 and P2. However, improvement—as measured by the AAT profile level or the BIAS-R mean percentage value—during P2 (with tDCS) was significantly higher than during P1 (p < 0.001; AAT sample and p = 0.005; BIAS-R sample). Thus, tDCS protocols can be implemented in early aphasia rehabilitation. Despite the limitations of the research design, which are also discussed from an implementation science perspective, this is preliminary evidence that an individually tailored anodal tDCS can have a significant add-on effect on the outcome of behavioral aphasia therapy in subacute aphasia.
Share If You Believe, Comment If You Doubt: The Effect of Source of Information, Trust, and Belief in Conspiracy Theories on Engagement with Facebook Posts
Authors: Atad Erga , David Yossi
Published: August 2024

This study examines the effect of one of three sources of information: a politician (authority figure), a physician (expert), and an ordinary person (non-expert) who appeared in a personal story related to a controversial issue (COVID-19 vaccination) on Facebook, on the willingness to engage with it. Using a between-subjects experiment (N = 848) conducted among Israeli adults (18 and older), we found a higher likelihood of sharing the story in interpersonal conversations than in other types of communications, regardless of the source that appeared in the story. However, respondents with high levels of institutional trust preferred sharing a politician’s story, while conspiracy believers tended to comment on an ordinary person’s story. The findings of the different patterns of communication behavior among conspiracy believers and people with high trust in political institutes contribute to our understanding of the mechanisms underlying the spread of misinformation in the digital age and during times of crisis.
Predicting Behaviour Patterns in Online and PDF Magazines with AI Eye-Tracking
Authors: Šola Hedda Martina , Qureshi Fayyaz Hussain , Khawaja Sarwar
Published: August 2024

This study aims to improve college magazines, making them more engaging and user-friendly. We combined eye-tracking technology with artificial intelligence to accurately predict consumer behaviours and preferences. Our analysis included three college magazines, both online and in PDF format. We evaluated user experience using neuromarketing eye-tracking AI prediction software, trained on a large consumer neuroscience dataset of eye-tracking recordings from 180,000 participants, using Tobii X2 30 equipment, encompassing over 100 billion data points and 15 consumer contexts. An analysis was conducted with R programming v. 2023.06.0+421 and advanced SPSS statistics v. 27, IBM. (ANOVA, Welch’s Two-Sample t-test, and Pearson’s correlation). Our research demonstrated the potential of modern eye-tracking AI technologies in providing insights into various types of attention, including focus, engagement, cognitive demand, and clarity. The scientific accuracy of our findings, at 97–99%, underscores the reliability and robustness of our research, instilling confidence in the audience. This study also emphasizes the potential for future research to explore automated datasets, enhancing reliability and applicability across various fields and inspiring hope for further advancements in the field.
Sanity through Insanity: The Use of Dark Humor among United States Veterans
Authors: Yoshimura Stephen M. , Bilbrey Gregory , Johns Stevi A. , Hall Kristin , Moore Nathan
Published: August 2024

Humor is generally known to effectively help individuals manage distress. Yet a variety of ways exist to engage in humor, and not all of them may be equally associated with desirable outcomes. The purpose of this study is to examine the extent to which dark humor is associated with the subjective well-being of United States military veterans. An online survey was announced on several social media pages populated by US veterans, to which 93 fully responded. Our findings indicate that the use of dark humor does not appear to be associated with a sense of connectedness, but the reported use of self-defeating types of dark humor was associated with lower levels of life satisfaction. Our hypothesis that increased feelings of connectedness to civilian and veteran/active-duty friends would predict increased reports of overall subjective well-being was supported. The implications of these findings for understanding the functions of dark humor are discussed.
Influence of Rock Block Content on Mechanical Properties of Coarse-Grained Fillers Stabilized with Fiber and Geopolymer
Authors: Yu Hongli , Ji Jiufa , Gu Leilei , Wang Shengnian , Wu Zhijian , Li Mingwei
Published: August 2024

This study employed fiber and geopolymer to enhance the engineering performance of coarse-grained fillers. By conducting a series of comparative mechanical tests, the ideal mass mixing ratio design of geopolymer and fiber was investigated first. Then, the influence of rock block content on the mechanical properties of coarse-grained fillers stabilized with fiber and geopolymer was explored. The deformation damage characteristics of fiber- and geopolymer-stabilized coarse-grained fillers with different rock block contents were also discussed in the final test. The results show that the ideal mass mixing ratio of geopolymer for coarse-grained filler stabilization was 15% of dry fine-grained soil in weight and the ideal dosage and length of fiber was 0.4% of dry fine-grained soil in weight and 1.2 × 10−2 m. The compressive strength of fiber- and geopolymer-stabilized coarse-grained fillers shows a tendency to increase first, then decrease, and then re-increase with the increase in rock block contents. The best compressive strength and resistance to deformation were achieved when the rock block content was 30%. The failure mode of fiber- and geopolymer-stabilized coarse-grained fillers translated from shearing slip to vertical splitting as the rock block content increased. This study can provide a reference and support for the engineering application of coarse-grained fillers stabilized with fiber and geopolymer.
Study on the Hydration Heat Effect and Pipe Cooling System of a Mass Concrete Pile Cap
Authors: Wang Bo , Song Yifan
Published: August 2024

Under the action of cement hydration heat, the construction environment, thermal insulation measures, and pipe cooling systems, a mass concrete pile cap is subject to a complex internal temperature field, which makes it difficult to control its internal surface temperature difference (TISTD), the internal adiabatic temperature rise (TIATR), and the surface temperature (TST). In this study, a mass concrete pile cap of a very large bridge (the length, width, and height were 26.40 m, 20.90 m, and 5.00 m, respectively, and the central-pier pile cap was constructed with C40 concrete) was taken as the research object. The control factors affecting the temperature field of the pile cap were determined by comparing the field temperature measurements with the values calculated with finite element software simulation analysis. By using Midas Civil (2022 v1.2) and Midas FEA (NX 2022) finite element software, these factors (the concrete mold temperature, the concrete surface convection coefficient, the ambient temperature, the pipe cooling system parameters, etc.) were numerically analyzed, and their influence laws and degrees were determined.
Non-Receptor Tyrosine Kinases: Their Structure and Mechanistic Role in Tumor Progression and Resistance
Authors: Eshaq Abdulaziz M. , Flanagan Thomas W. , Hassan Sofie-Yasmin , Al Asheikh Sara A. , Al-Amoudi Waleed A. , Santourlidis Simeon , Hassan Sarah-Lilly , Alamodi Maryam O. , Bendhack Marcelo L. , Alamodi Mohammed O. , Haikel Youssef , Megahed Mossad , Hassan Mohamed
Published: August 2024

Protein tyrosine kinases (PTKs) function as key molecules in the signaling pathways in addition to their impact as a therapeutic target for the treatment of many human diseases, including cancer. PTKs are characterized by their ability to phosphorylate serine, threonine, or tyrosine residues and can thereby rapidly and reversibly alter the function of their protein substrates in the form of significant changes in protein confirmation and affinity for their interaction with protein partners to drive cellular functions under normal and pathological conditions. PTKs are classified into two groups: one of which represents tyrosine kinases, while the other one includes the members of the serine/threonine kinases. The group of tyrosine kinases is subdivided into subgroups: one of them includes the member of receptor tyrosine kinases (RTKs), while the other subgroup includes the member of non-receptor tyrosine kinases (NRTKs). Both these kinase groups function as an “on” or "off" switch in many cellular functions. NRTKs are enzymes which are overexpressed and activated in many cancer types and regulate variable cellular functions in response to extracellular signaling-dependent mechanisms. NRTK-mediated different cellular functions are regulated by kinase-dependent and kinase-independent mechanisms either in the cytoplasm or in the nucleus. Thus, targeting NRTKs is of great interest to improve the treatment strategy of different tumor types. This review deals with the structure and mechanistic role of NRTKs in tumor progression and resistance and their importance as therapeutic targets in tumor therapy.
Prediction of PSA Response after Dexamethasone Switch during Abiraterone Acetate + Prednisolone Treatment of Metastatic Castration-Resistant Prostate Cancer Patients
Authors: Fekete Bertalan , Biró Krisztina , Gyergyay Fruzsina , Polk Nándor , Horváth Orsolya , Géczi Lajos , Patócs Attila , Budai Barna
Published: August 2024

Background: The aim was to elaborate a predictive model to find responders for the corticosteroid switch (from prednisolone to dexamethasone) at the first prostate-specific antigen (PSA) progression (≥25% increase) during abiraterone acetate (AA) treatment of metastatic castration-resistant prostate cancer (mCRPC) patients. Methods: If PSA has decreased (≥25%) after switch, patients were considered responders. Logistic regression of 19 dichotomized parameters from routine laboratory and patients’ history was used to find the best model in a cohort of 67 patients. The model was validated in another cohort of 42 patients. Results: The model provided 92.5% and 90.5% accuracy in the testing and the validation cohorts, respectively. Overall the accuracy was 91.7%. The AUC of ROC curve was 0.92 (95% CI 0.85–0.96). After a median follow-up of 27.9 (26.3–84) months, the median AA+dexamethasone treatment duration (TD) in non-responders and responders was 4.7 (3.1–6.5) and 11.1 (8.5–12.9) months and the median overall survival (OS) was 23.2 (15.6–25.8) and 33.5 (26.1–38) months, respectively. Multivariate Cox regression revealed that responsiveness was an independent marker of TD and OS. Conclusions: A high accuracy model was developed for mCRPC patients in predicting cases which might benefit from the switch. For non-responders, induction of the next systemic treatment is indicated.
Enhanced In Vitro Recapitulation of In Vivo Liver Regeneration by Co-Culturing Hepatocyte Organoids with Adipose-Derived Mesenchymal Stem Cells, Alleviating Steatosis and Apoptosis in Acute Alcoholic Liver Injury
Authors: Ock Sun A , Kim Seo-Yeon , Kim Young-Im , Ju Won Seok , Lee Poongyeon
Published: August 2024

Hepatocyte organoids (HOs) have superior hepatic functions to cholangiocyte-derived organoids but suffer from shorter lifespans. To counteract this, we co-cultured pig HOs with adipose-derived mesenchymal stem cells (A-MSCs) and performed transcriptome analysis. The results revealed that A-MSCs enhanced the collagen synthesis pathways, which are crucial for maintaining the three-dimensional structure and extracellular matrix synthesis of the organoids. A-MSCs also increased the expression of liver progenitor cell markers (KRT7, SPP1, LGR5+, and TERT). To explore HOs as a liver disease model, we exposed them to alcohol to create an alcoholic liver injury (ALI) model. The co-culture of HOs with A-MSCs inhibited the apoptosis of hepatocytes and reduced lipid accumulation of HOs. Furthermore, varying ethanol concentrations (0–400 mM) and single-versus-daily exposure to HOs showed that daily exposure significantly increased the level of PLIN2, a lipid storage marker, while decreasing CYP2E1 and increasing CYP1A2 levels, suggesting that CYP1A2 may play a critical role in alcohol detoxification during short-term exposure. Moreover, daily alcohol exposure led to excessive lipid accumulation and nuclear fragmentation in HOs cultured alone. These findings indicate that HOs mimic in vivo liver regeneration, establishing them as a valuable model for studying liver diseases, such as ALI.
Preserving Genome Integrity: Unveiling the Roles of ESCRT Machinery
Authors: La Torre Mattia , Burla Romina , Saggio Isabella
Published: August 2024

The endosomal sorting complex required for transport (ESCRT) machinery is composed of an articulated architecture of proteins that assemble at multiple cellular sites. The ESCRT machinery is involved in pathways that are pivotal for the physiology of the cell, including vesicle transport, cell division, and membrane repair. The subunits of the ESCRT I complex are mainly responsible for anchoring the machinery to the action site. The ESCRT II subunits function to bridge and recruit the ESCRT III subunits. The latter are responsible for finalizing operations that, independently of the action site, involve the repair and fusion of membrane edges. In this review, we report on the data related to the activity of the ESCRT machinery at two sites: the nuclear membrane and the midbody and the bridge linking cells in the final stages of cytokinesis. In these contexts, the machinery plays a significant role for the protection of genome integrity by contributing to the control of the abscission checkpoint and to nuclear envelope reorganization and correlated resilience. Consistently, several studies show how the dysfunction of the ESCRT machinery causes genome damage and is a codriver of pathologies, such as laminopathies and cancer.
Investigating the Temperature-Dependent Kinetics in Humidity-Resilient Tin–Titanium-Based Metal Oxide Gas Sensors
Authors: Gherardi Sandro , Astolfi Michele , Gaiardo Andrea , Malagù Cesare , Rispoli Giorgio , Vincenzi Donato , Zonta Giulia
Published: August 2024

Humidity is a well-known interference factor in metal oxide (MOX) gas sensors, significantly impacting their performance in various applications such as environmental monitoring and medical diagnostics. This study investigates the effects of adsorbed water on MOX conductivity using two different materials: pure tin oxide (SnO2) and a tin–titanium–niobium oxide mixture (SnTiNb)xO2 (STN). The results reveal that (SnTiNb)xO2 sensors exhibit reduced sensitivity to humidity compared to pure tin oxide, rendering them more suitable for applications where humidity presence is critical. We aimed to shed light on a still controversial debate over the mechanisms involved in the water surface interactions for the aforementioned materials also by exploring theoretical studies in the literature. Experimental analysis involves varying temperatures (100 to 800 °C) to understand the kinetics of surface reactions. Additionally, a brief high-temperature heating method is demonstrated to effectively remove adsorbed humidity from sensor surfaces. The study employs Arrhenius-like plots for graphical interpretation, providing insights into various water adsorption/desorption phenomena. Overall, this research contributes to a deeper understanding of the role of humidity in MOX gas sensor mechanisms and offers practical insights for sensor design and optimization.
Comparison of Titanium versus Resorbable Intramedullary Nailing in Pediatric Forearm Fractures
Authors: Dávid Ádám László , Mucsina Flóra , Antal Eszter , Lamberti Anna Gabriella , Lőrincz Aba , Józsa Gergő
Published: August 2024

Pediatric forearm fractures, particularly involving the shaft or diaphysis, are common injuries typically resulting from accidental trauma during various activities. Traditional treatment involves closed reduction and casting; however, surgical intervention may be necessary in certain cases. The gold standard surgical approach utilizes elastic stable intramedullary nailing (ESIN), but a newer technique uses bioabsorbable intramedullary nails made of poly(lactic-co-glycolic acid) (PLGA). This study aims to compare the outcomes of these two surgical methods in pediatric diaphyseal forearm fractures. We retrospectively reviewed 86 patients who underwent operative treatment due to the diaphyseal fractures of the forearm in the Surgical Division, Department of Pediatrics, Medical School, University of Pécs, Pécs, Hungary between 2018 and September 2022. The mean age was 9.48 (ranging from 4 to 17). A total of 41 patients underwent surgery with PLGA implants (RESIN technique), while 45 patients were treated with titanium elastic nails (ESIN technique). Various factors including patient demographics, injury mechanisms, fracture characteristics, and complications were assessed. Both groups showed similar gender distribution, with a majority of fractures occurring in boys (the male–female ratio was 31:10 in the PLGA group, while in the titanium elastic nailing (TEN) group, this ratio was 29:16, with no statistical difference between the groups (p > 0.005). The average age of the patients treated with PLGA implants (8.439 years) was lower compared to those treated with titanium nails (10.422 years). A statistically significant difference was found regarding the average age of the two groups (p = 0.0085). Left-sided injuries were more prevalent in both groups (59% of the cases in the PLGA group and 69% in the TEN group, with no statistically significant difference, p = 0.716), and fractures typically involved both the radius and ulna. This represents 93% of the cases in the PLGA group and 80% in the TEN group. Regarding the involvement of bones, we also did not find a statistically significant difference (p = 0.123). The mechanisms of injury predominantly involved indirect force, such as falls (30 cases in the PLGA group and 27 cases in the TEN group), and no statistically significant difference was found (p = 0.139) regarding the mechanism of the injury. Complication rates were lower in the PLGA group (7%) compared to the titanium group (20%). The treatment of pediatric diaphyseal forearm fractures using PLGA implants appears to be a viable alternative to traditional titanium implants. Advantages include no need for secondary surgery and associated cost savings and reduced complication rate and stress associated with anesthesia and surgery. Prospective randomized trials are warranted to further validate these findings and explore long-term outcomes.
Impact of Cyberbullying on Academic Performance and Psychosocial Well-Being of Italian Students
Authors: Ragusa Antonio , Núñez-Rodríguez Sandra , Vaz Paulo , Silva José , Caliciotti Virginia , González-Bernal Jerónimo J. , López-Rivero Alfonso J. , Petrillo Ema , Gatto Manuela , Obregón-Cuesta Ana Isabel , González-Santos Josefa
Published: August 2024

Cyberbullying is a growing problem in the Italian educational sector, with a prevalence of 17%. This study analyzes its impact on the psychosocial well-being and academic performance of Italian adolescents. Method: A cross-sectional study was conducted with 502 students from six schools in different Italian regions, using the European Cyberbullying Intervention Project Questionnaire (ECIPQ) to assess cyberbullying, in addition to collecting data on satisfaction, friends, and academic performance. Chi-square and ANOVA analyses were conducted to identify significant associations between the variables. Results: The analyses showed significant associations between cyberbullying and gender and in psychosocial well-being, with significant differences in personal satisfaction and body satisfaction. On the other hand, there were no significant differences in academic performance or in the ability to make new friends, although victims showed a significantly lower ability to make new friends compared to those who were neither victims nor aggressors. Conclusions: Cyberbullying has a significant impact on students’ psychosocial well-being, especially on personal satisfaction and school happiness, making it essential to implement interventions that promote safe school environments to mitigate these negative effects.
Study on Characterization of Phase Transition in Continuous Cooling of Carbon Steel Using In Situ Thermovoltage Measurement
Authors: Wang Qihui , Chen Kun , Liu Kejia , Wang Lianbo , Chu Yu , Xie Bichen
Published: August 2024

In this paper, a self-designed and enhanced thermovoltage measuring device was built to capture thermovoltage curves of 45 steel during continuous cooling. The phase zones of the thermovoltage curve were interpreted based on the Engel–Brewer electron theory and Fe-Fe3C phase diagram. The results show that the curve was stratified into three homogeneous phase zones and two-phase transition zones as follows: Zone Ι: single-phase austenite (A) zone; Zone III: austenite and ferrite (A+F) homogeneous phase zone; Zone V: ferrite and pearlite (P+F) homogeneous phase zone; Zone II: austenite to ferrite (A-F) phase transition zone; and Zone IV: austenite to pearlite (A-P) phase transition zone. Notably, the deflection point marked the transition temperature, which indicates that the thermovoltage curve can quantitatively characterize phase formation and transformation, as well as the phase transformation process. Furthermore, the sample was quenched at the measured ferrite phase transition temperature. Microstructure observations, electron probe microanalyzer (EPMA) and microhardness measurements corroborated our findings. Specifically, our experiments reveal ferrite precipitation first from the cold end at the phase transition temperature, leading to increased carbon content in adjacent austenite. The results of this study achieved the in situ characterization of bulk transformations during the materials heat treatment process, which expands the author’s research work conducted previously.
Twin Peaks: Interrogating Otolith Pairs to See Whether They Keep Their Stories Straight
Authors: Lord Clara , Berland Sophie , Haÿ Vincent , Medjoubi Kadda , Keith Philippe
Published: August 2024

To tackle the question of the reliability of otoliths as recorders of individual life events, we compared the information enclosed in otolith pairs: the sagittae pair and the sagitta/lapillus pair. We used the synchrotron XRF scanning imaging method, which enabled the comparison of this information at both global and hyperfine scales. Using otoliths of diadromous pipefish, we compared element incorporation in each pair with a focus on (i) environment and transition between water bodies with strontium (Sr) and heavy metals, (ii) temporal information and age estimation based on sulphur (S) incorporation, and (iii) otolith growth and biomineralization processes with zinc (Zn). Results show that the global information in terms of Sr and heavy metals given by both otoliths of a pair is the same and that any otolith may be used to retrieve such global data. In terms of S-based growth increment counts, the numbers are the same between two otoliths of the same kind, but the sagitta/lapillus pairs show a significant difference. Hyperfine-scale analysis of element distribution reveals that a given otolith is under the control of specific growth mechanisms, which can lead to heterogeneous elemental incorporation. The present results lead us to consider otolith growth dynamics and biomineralization processes in the context of a fluid mosaic perspective.
Coexistence of Large In-Plane and Out-of-Plane Piezoelectric Response in Group III–VI XMAY2 (X = I; M = Ti, Zr; A = Al, Ga; Y = S, Se) Monolayers
Authors: Li Zujun , Zhou Yushan , Guo Xiuping , Peng Junhao , Dong Huafeng
Published: August 2024

Flexible materials with both in-plane and out-of-plane piezoelectric coefficients are needed in the development of advanced nanoelectromechanical systems. However, the challenge is to find flexible materials with the coexistence of in-plane and -out-of-plane piezoelectric responses, which hinders the progress of high-performance piezoelectric sensor development. In this paper, we propose the flexible XMAY2 (X = I; M = Ti, Zr; A = Al, Ga; Y = S, Se) monolayers, which belong to the group III-VI XMAY2 family, which showcase notable in-plane and out-of-plane piezoelectric coefficients. The in-plane (d11) and out-of-plane (d31) piezoelectric coefficients of the XMAY2 monolayers vary from 5.20 to 7.04 pm/V and from −0.23 to 0.48 pm/V, respectively. The large in-plane and out-plane piezoelectric responses coexist (d11 = 7.04 pm/V; d31 = 0.48 pm/V) in the IZrGaS2 monolayer, which is larger than other materials in the XMAY2 family, such as SMoSiN2 (d11 = 2.51; d31 = 0.28 pm/V). In addition, the mechanical and transport properties of XMAY2 demonstrate its impressive flexibility characteristics as well as its efficient electrical conductivity. Due to inversion symmetry breaking in both atomic structure and charge distribution of XMAY2 monolayers, the group III-VI XMAY2 family exhibits a potentially rich scope of applications in the field of piezoelectricity.
Finding Isolated Aquatic Habitat: Can Beggars Be Choosers?
Authors: Husband Danielle M. , McIntyre Nancy E.
Published: August 2024

In a two-year field study across 58 isolated wetlands in Texas (USA), we examined whether odonate (Insecta: Odonata) assemblages were structured by local environmental filters or instead simply reflected the use of any available water in this semi-arid region. Cluster analysis resolved three wetland groupings based on environmental characteristics (hydroperiod, water chemistry, vegetation); 37 odonate species were detected at these wetlands. The most speciose assemblages occurred at wetlands with longer hydroperiods; these sites also had the most species found at no other wetland type. Ordination plots indicated some filtering with respect to the hydroperiod, but there was only mixed or weak support with respect to other local factors. Because water persistence was the strongest driver maintaining odonate diversity in this region, regardless of water quality or vegetation, beggars cannot be choosers in this system and conservation efforts can focus on water maintenance or supplementation.
Updated and Corrected List of Hosts of European Pinnotherids (Crustacea, Decapoda, and Pinnotheridae): Relationship between Number of Hosts and Distribution
Authors: Cuesta Jose A. , Román Sara , Muñoz Isabel , Rodríguez de la Rúa Ana , Farias Carlos , Silva Luis , Delgado Marina
Published: August 2024

The present work provides an updated and corrected list of hosts for the five European species of pinnotherid crabs, taking into consideration all recent published works as well as new data obtained in the present study. In relation to the number of hosts, there are two groups of species, one composed by Pinnotheres pisum and Afropinnotheres monodi with the highest number of hosts, and a second group, with a reduced number of hosts and more specific taxa, consisting of three other species: Nepinnotheres pinnotheres, Pinnotheres bicristatus, and P. pectunculi. When studying the relationships between host preferences, host distributions, and pea crab distributions, we could not find a clear direct relationship between these parameters. Temperature is also probably an important influence and relevant factor responsible for the distribution of pinnotherid crabs, and this may be independent from the potential distribution due to the distribution of hosts.
Four Novel Species of Kastovskya (Coleofasciculaceae, Cyanobacteriota) from Three Continents with a Taxonomic Revision of Symplocastrum
Authors: Jusko Brian M. , Johansen Jeffrey R. , Mehda Smail , Perona Elvira , Muñoz-Martín M. Ángeles
Published: August 2024

Studies performed in North America, Africa, and South America have led to the isolation of four new species of Kastovskya, a filamentous cyanobacterial genus that before this manuscript had only one species, Kastovskya adunca from Chile. Kastovskya nitens and K. viridissima were isolated from soils on San Nicolas Island, K. sahariensis was isolated from hypolithic habitats from the Sahara Desert in Algeria, and K. circularithylacoides was isolated from hypolithic habitats in Chile. The molecular analyses are corroborated by morphological data, morphometric analysis, and ecological and biogeographical considerations for robust polyphasic descriptions of all taxa. The peculiar transatlantic distribution of this genus bears similarity to other taxa in recently published studies and is in agreement with a hypothesis suggesting that cyanobacteria in Africa may disperse to the Americas on dust particles during windstorms. This work is unusual in that species in a single rare cyanobacterial genus with a disjunct distribution are described simultaneously from three continents. The 16S rRNA gene analyses performed for this study also revealed that another recent genus, Arizonema, is clearly a later synonym of Symplocastrum. This issue is resolved here with the collapsing of the type species Arizonema commune into Symplocastrum flechtnerae.
A Performance Analysis of Hybrid and Columnar Cloud Databases for Efficient Schema Design in Distributed Data Warehouse as a Service
Authors: Rabelo Ferreira Fred Eduardo Revoredo , do Nascimento Fidalgo Robson
Published: August 2024

A Data Warehouse (DW) is a centralized database that stores large volumes of historical data for analysis and reporting. In a world where enterprise data grows exponentially, new architectures are being investigated to overcome the deficiencies of traditional Database Management Systems (DBMSs), driving a shift towards more modern, cloud-based solutions that provide resources such as distributed processing, columnar storage, and horizontal scalability without the overhead of physical hardware management, i.e., a Database as a Service (DBaaS). Choosing the appropriate class of DBMS is a critical decision for organizations, and there are important differences that impact data volume and query performance (e.g., architecture, data models, and storage) to support analytics in a distributed cloud environment efficiently. In this sense, we carry out an experimental evaluation to analyze the performance of several DBaaS and the impact of data modeling, specifically the usage of a partially normalized Star Schema and a fully denormalized Flat Table Schema, to further comprehend their behavior in different configurations and designs in terms of data schema, storage form, memory availability, and cluster size. The analysis is done in two volumes of data generated by a well-established benchmark, comparing the performance of the DW in terms of average execution time, memory usage, data volume, and loading time. Our results provide guidelines for efficient DW design, showing, for example, that the denormalization of the schema does not guarantee improved performance, as solutions performed differently depending on its architecture. We also show that a Hybrid Processing (HTAP) NewSQL solution can outperform solutions that support only Online Analytical Processing (OLAP) in terms of overall execution time, but that the performance of each query is deeply influenced by its selectivity and by the number of join functions.
Three-Dimensional Analysis of the Maxillary Sinuses in Ancient Crania Dated to the V–VI Centuries BCE from Opi (Italy): Volumetric Measurements in Ancient Skulls from the Necropolis of Opi, Abruzzi, Italy
Authors: Festa Felice , D’Anastasio Ruggero , Benazzi Stefano , Macrì Monica
Published: August 2024

Cone beam computed tomography (CBCT) can provide precise information about complex anatomical structures as it is characterised by rapid volumetric image acquisition with high resolution. The aim of this study was to provide measurements for 20 ancient skulls of the Samnite people found in the necropolis of Opi, a small and isolated mountain village in Abruzzo, a region in central Italy. All the images (left and right) of the 20 ancient skulls from Opi were acquired. All the data are the property of the Department of Innovative Technologies in Medicine and Dentistry of G. D’Annunzio University, Chieti, and different parameters (area and volume) were measured and evaluated. The mean and standard deviation of the facial measurements were also calculated. All the data were subjected to statistical analysis. CBCT scan data of 20 fossil skulls did not show significant values regarding the MS area and the volume between the right and left sides. In the ancient skulls, no difference was found between the right and left sides.
Assessing, Advising, and Advancing the Filling Practices of the Radiology Request Form in Africa: A Systematic Review
Authors: Hajalamin Mohamed , Awadalla Almontasir , Mukhtar Mahmoud
Published: August 2024

Despite the increased use of diagnostic imaging in Africa, the completion of the Radiology Request Form (RRF) remains suboptimal, often relying on paper-based communication. To examine the practices surrounding RRF completion in the African continent, on 25 March 2024, we conducted a systematic review of peer-reviewed articles describing the practice in African settings. Non-African studies, studies involving non-human subjects, and articles examining the practice of the RRF for interventional usage were excluded. Our search involves PubMed/MEDLINE, ScienceDirect, Scopus, Web of Science, Google Scholar, and African Journals Online. The included studies were 3004, of which 30 met the inclusion criteria. These studies span eight countries and highlighted several shortcomings, including the usage of informal forms, unconventional abbreviations, illegibility, inaccuracy, and the lack of important fields from institutional forms, commonly the last menstrual period and the referrer’s contact details. We also found widespread non-compliance in all RRF fields; half of the studies did not have an adequately filled form. Incomplete RRFs lead to delayed imaging, increased workloads for radiographers and radiologists, and potential misdiagnoses due to insufficient information. It will also impede the application of radiation protection principles. To address these challenges, empowering radiographers and radiologists and encouraging best practices is essential. Regular audits and educational initiatives aimed at clinicians are recommended. While transitioning to a paperless communication system might help, implementing nationwide quality improvement projects to standardise radiology request forms is currently more feasible.
Comparative Efficacy and Safety of Self-Expandable vs. Balloon-Expandable Stent Grafts in Visceral Artery Aneurysm Management
Authors: Talaie Reza , Torkian Pooya , Spano Anthony , Mahjoubnia Alireza , Flanagan Siobhan M. , Rosenberg Michael , Lin Jian , Golzarian Jafar , Shrestha Preshant
Published: August 2024

Purpose: This study assesses the efficacy and safety of self-expandable (SE) versus balloon-expandable (BE) stent grafts for managing visceral artery aneurysms (VAAs), focusing on procedural success and complication rates. Materials and Methods: We conducted a retrospective analysis of VAA patients treated at our institution from April 2006 to September 2021. The study reviewed patient demographics, aneurysm characteristics, treatment details, and outcomes, including endoleaks. Results: Among the 23 patients analyzed, splenic artery aneurysms represented 44% of cases. Fifteen patients were treated with balloon-expandable stent grafts (BE SGs), and eight patients were treated with self-expandable stent grafts (SE SGs). For saccular aneurysms, the average neck size was 10.10 ± 8.70 mm in the BE group versus 18.50 ± 3.40 mm in the SE group (p = 0.23), with an average sac size of 20.10 ± 18.9 mm in the BE group versus 15.60 ± 12.7 mm in the SE group (p = 0.16). The average sac-to-neck ratio was 1.69 ± 2.23 in the BE group versus 1.38 ± 0.33 in the SE group (p = 0.63). The BE group exhibited a significantly higher endoleak rate (60%) compared to the SE group (12.5%; p = 0.03). Conclusions: While further investigation is needed to fully assess the outcomes of stent graft treatment for VAAs, initial data show a significantly higher endoleak rate with BE SGs compared to SE SGs. The SE SGs may offer better outcomes due to their superior ability to conform to tortuous and mobile visceral arteries.
Drone Arc Routing Problems and Metaheuristic Solution Approach
Authors: Altin Islam , Sipahioglu Aydin
Published: August 2024

The drone arc routing problem (DARP) is one of the arc routing problems (ARPs) that has been studied by researchers recently. Unlike traditional ARPs, drones can travel directly between any two points in the graph. Due to the flexibility of drones, it is possible to use edges not defined in the graphs when deadheading the edges. This advantage of drones makes this problem more challenging than any other ARP. With this study, the energy capacities of drones are considered in a DARP. Thus, a novel DARP called the drone arc routing problem with deadheading demand (DARP-DD) is addressed in this study. Drone capacities are used both when servicing the edges and when deadheading the edges in the DARP-DD. A special case of the DARP-DD, called the multiple service drone arc routing problem with deadheading demand (MS-DARP-DD), is also discussed, where some critical required edges may need to be served more than once. To solve these challenging problems, a simulated annealing algorithm is used, and the components of the algorithm are designed. Additionally, novel neighbor search operators are developed in this study. The computational results show that the proposed algorithm and its components are effective and useful in solving the DARP-DD and MS-DARP-DD.
Exact Expressions for Kullback–Leibler Divergence for Multivariate and Matrix-Variate Distributions
Authors: Nawa Victor , Nadarajah Saralees
Published: August 2024

The Kullback–Leibler divergence is a measure of the divergence between two probability distributions, often used in statistics and information theory. However, exact expressions for it are not known for multivariate or matrix-variate distributions apart from a few cases. In this paper, exact expressions for the Kullback–Leibler divergence are derived for over twenty multivariate and matrix-variate distributions. The expressions involve various special functions.