bluuebunny/crossref_metadata_2025 huggingface dataset:
A Consensual Qualitative Research on the Counselor Authenticity Experience of Consensual Divorce Counselors
Authors:   Korean Academy Welfare Counselling, Lee Juhee , Kim Eunjin , Park Sunhee
Published: March 2024

This study attempted to analyze the meaning of authenticity perceived by consensual divorce counselors, how the counselor’s authenticity is promoted, and how the counselor’s authenticity affects counseling performance. For this purpose, ten uncontested divorce counselors were interviewed in depth and the data were analyzed using Consensual Qualitative Research(CQR). The data were drawn into a total of 5 areas, 11 sub-areas, and 42 categories. First, the uncontested divorce counselors conceptualized authenticity as an attitude to understand and accept the client’s problem and to have a willingness to help. Second, counselor’s effort and client’s positive response were the factors to promote counselor’s authenticity. Third, the obstacles to the counselor’s authenticity were the client’s resistance and rejection, the counselor’s motivation and passion, and the situational limitations. Fourth, counselors’ personal coping and counselors’ coping were found to be the recovery factors of counseling divorce counselors’ authenticity. Fifth, it was found that the effect of the authenticity manifestation of the uncontested divorce counselor was that the client’s perception changed, the counselor became proud as a counselor, and the result of successful counseling was obtained. Therefore, since authenticity affects therapeutic effect in counseling relationship, it is suggested that efforts should be made to develop authenticity of uncontested divorce counselors.
A trade-off optimization model of environment impact and manufacturing cost for machining parts
Authors: Zhang Lei , Tao Kaibo , Zheng Yu , Zhu Kuankuan , Fang Junwei , Su Jin
Published: March 2024

Motivation: Throughout the life cycle, the environmental impact and manufacturing costs of a part are largely determined at the design stage. Therefore, a part design optimization method considering these two factors is proposed in this paper. At the same time, the comprehensive benefit is taken as the trade-off of these two factors. The reduction of the comprehensive benefit indicates that the optimized part has achieved better environmental and economic performance results.

Methods: Firstly, the model is reconstructed using the dimension-driven method, and the feature information of the new part is extracted. Then, machining process planning is carried out based on the feature information. Secondly, a design optimization model for the comprehensive benefit is established based on the genetic algorithm. The model takes the dimension parameters of the part as the optimization variables and the reduction of the comprehensive benefit as the optimization objective. With the help of the Simulation plug-in for SolidWorks, the static analysis of the optimized model is conducted to determine whether it meets the performance requirements. Finally, the design optimization prototype system oriented to comprehensive benefit is established. The feasibility and effectiveness of the proposed method are verified by taking the intermediate shaft of the belt conveyor reducer-sixth order step shaft as an example.

Results: The case study shows that the optimization result of comprehensive benefit is 1.63%, which verifies the feasibility and effectiveness of the part design optimization method proposed in this paper.
Upaya Peningkatan Pengetahuan Melalui Edukasi Penggunaan Obat Suppositoria Pasien Rawat Jalan Puskesmas Gadang Hanyar Banjarmasin
Authors: Achyadi Ryan , Muliani Putri Sari , Sari Okta Muthia , Putra Aditya Maulana Perdana , Hakim Ade Syarif
Published: March 2024

Suppositoria diresepkan untuk pasien yang tidak dapat mengkonsumsi obat-obatan melalui rute oral. Penggunaan jenis obat suppositoria berbeda dengan penggunaan obat pada umumnya seperti obat tablet atau sirup. Masyarakat masih belum familiar terkait penggunaan suppositoria. Dengan menggunakan suppositoria secara tepat, memungkinkan obat untuk bekerja dengan lebih efektif dan memberikan manfaat yang diharapkan. Tujuan promosi kesehatan adalah meningkatkan pengetahuan terkait penggunaan suppositoria. Promosi kesehatan menerapkan metode ceramah dalam pemberian edukasi. Selama kegiatan dilakukan evaluasi dengan kuesioner. Kegiatan promosi kesehatan telah dilaksanakan pada 29 April 2023 dengan sasaran pasien rawat jalan yang berkunjung ke Puskesmas Gadang Hanyar.  Sebanyak 12 peserta ikut kegiatan. Hasil dari kegiatan diperoleh pengetahuan peserta pada pre-test sebesar 55% dengan kategori kurang. Setelah edukasi materi penggunaan suppositoria, pengetahuan peserta sebesar 84.17% dengan kategori baik. Pengetahuan pasien rawat jalan Puskesmas Gadang Hanyar terkait penggunaan suppositoria mengalami peningkatan dengan kategori pengetahuan baik setelah pemberian edukasi oleh apoteker. Kata Kunci: Apoteker, Dagusibu, Oral, Rektal Suppositories are prescribed for people who have difficulty ingesting medications orally. Suppository medication administration differs from conventional medications, such as tablets or syrups. The general populace is mostly unacquainted with the application of suppositories. Proper use of suppositories enhances the efficacy of the drug and ensures that the desired advantages are achieved. The objective of health promotion is to increase awareness of the use of storages. Health promotion uses the lecture method to provide education. A questionnaire was used to conduct an evaluation during the activity. On 29 April 2023, health promotion initiatives were carried out specifically for outpatients who visited the Gadang Hanyar Public Health Centre.  There were a total of 12 individuals involved in the activity. The exercise yielded a pre-test knowledge score of 55% for participants, falling into the lower range. Following the educational session on the administration of suppositories, the participants' level of knowledge reached 84.17%, placing it in the "good" category. The instruction provided by pharmacists has significantly improved the understanding of outpatients at the Gadang Hanyar Health Centre regarding the use of suppositories, resulting in a substantial improvement in their knowledge category.
Edukasi Pentingnya Senyawa Fe dalam Mengatasi Anemia pada Remaja Putri
Authors: Rahmawati Rahmawati , Farik Azqi As , Akifah Ghina , Fajeriyati Nurul
Published: March 2024

Kasus anemia defisiensi zat besi terjadi pada dua milyar penduduk dunia dan sebesar 29,9% nya dialami oleh remaja putri. Prevalensi anemia di Indonesia mencapai 23,7%  dan terkhusus Kalimantan Selatan prevalensi anemia pada remaja putri sebesar adalah 52,98%  Anemia pada remaja beresiko terjadinya pertumbuhan fisik dan maturitas seksual yang melambat, serta penurunan konsentrasi dalam belajar. Program pencegahan anemia terus dilakukan oleh pemerintah, khususnya pada remaja putri dan wanita usia subur. Kegiatan edukasi ini bertujuan untuk mendukung program pemerintah dan mendeskripsikan pengetahuan remaja putri tentang senyawa Fe dalam mengatasi anemia di SMK Al-Furqon Banjarmasin Utara, Kota Banjarmasin, Kalimantan Selatan. Kegiatan dilakukan dengan metode sosialisasi menggunakan media Power Point Presentation (PPT) dan leaflet, dimana dilakukan pemaparan materi terkait pentingnya peranan senyawa Fe dalam mengatasi anemia pada remaja putri. Berdasarkan pada hasil posttest terlihat bahwa tingkat pengetahuan remaja putri terkait anemia mengalami peningkatan, sehingga dapat dinyatakan bahwa edukasi yang telah dilakukan, dapat memberikan peningkatan pengetahuan terkait pentingnya senyawa Fe dalam mengatasi anemia. Kata Kunci: Anemia, Senyawa Fe, Program Preventive, Edukasi Iron deficiency anemia cases occured in two billion people in the world and 29.9% of them are experienced by adolescent girl. The prevalence of anemia in Indonesia reached 23.7% and specifically in South Borneo the prevalence of anemia in adolescent girls was 52.98%. Anemia in adolescents is at risk of slowing physical growth and sexual maturity, as well as decreased concentration in studying. The government continues to carry out anemia prevention programs, especially for adolescent girls and women of childbearing age. This educational activity aims to support government programs and describe the knowledge of young women about Fe compounds in treating anemia at Al-Furqon Vocational School, North Banjarmasin, Banjarmasin City, South Kalimantan. These activities are carried out using the socialization method using Power Point Presentation (PPT) media and leaflets. where material was presented regarding the importance of the role of Fe compounds in overcoming anemia in adolescent girls. Based on the posttest results, showed that the level of knowledge of adolescent girl regarding anemia has increased, so it can be stated that the education that has been carried out could provide knowledge enhancement regarding the importance of Fe in treating anemia.
PENGARUH CORPORATE GOVERNANCE TERHADAP CORPORATE FINANCIAL FRAUD PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI
Authors: Cindy Ellysa  , Marheni Dewi Khornida
Published: March 2024

This study aims to determine the effect of board size, financial expertise, board independence, rationalization, female board, firm size, leverage ratio (LEV) and asset ratio (ROA) on corporate financial reporting in manufacturing companies listed on the Stock Exchange in 2016 - 2020 The sampling technique used is purposive sampling with a final sample of 80 companies. The analysis used in this research is descriptive statistics and panel regression. The results of this study indicate that the size of the board, financial expertise, board independence, rationalization, and do not have a significant effect on the size of the company's finances. While the financial board has a significant influence on fraud, which means a high number of company ownership can reduce the possibility of an incident, then the leverage ratio (LEV) indicates a high debt so there is a high probability of fraud in the company, assets (ROA) has a high positive significant influence ROA can become pressure for the company so that it is likely to take company actions.
DETERMINAN PENGGUNAAN INFORMASI AKUNTANSI PADA USAHA MIKRO KECIL DAN MENENGAH (UMKM) SE KALIMANTAN SELATAN
Authors: Safrida Lili , Sarwani  , Nordiansyah M.
Published: March 2024

The purpose of this research was to analyze the effect of business scale, business age, education, accounting training, and MSMEs perception about accounting on the use of accounting information in South Kalimantan Province MSMEs. This research used quantitative methos. The population in this research were South Kalimantan Province MSMEs listed on Department of Cooperatives, Micro Enterprises and Manpower of South Kalimantan Province in 2022. The sample method used was convenience sampling. Sample in this research was determined by slovin’s formulas and the total of sample was 86 MSMEs. The source of data used was primary data, data analysis techniques using multiple linear regressian analysis which were processed by SPSS 26 version. Based on the result of this research indicated that accounting training had an effect on the use of accounting information. Meanwhile the business scale, business age, education, and MSMEs perception about accounting had no effect on the use of accounting information.
PENGARUH DIREKSI PEREMPUAN PADA PERFORMA BANK DI ASIA TENGGARA
Authors: Oktaviani Ayu , Nor Hikmah  , Novika Rosari  , Wahyu  , Hamdani
Published: March 2024

This study aims to find out the impact of the women's directory on the performance of financial companies imitating the Tobin's Q ratio. This research uses the Weighted Least Square method with the IBM SPSS application. Data collection techniques using the documentation method. The data in this study consisted of secondary data taken from the Indonesia Stock Exchange or related company websites (the number of samples in this study were 49 companies spread across Southeast Asia from 2017 - 2020). The results of this study indicate that the variables of female directors, profitability and company size have no effect on the company's financial performance, while the leverage variable has a significant positive effect on the company's financial performance.
ANALISIS TINGKAT KEPUASAN WISATAWAN TERHADAP KUALITAS SAPTA PESONA DI KAWASAN WISATA CIHAMPELAS KOTA BANDUNG
Authors: Syamsiah Nurul , Yudi Satriadi  , Asep Achmad Muhlisian
Published: March 2024

This study discussed the level of tourist satisfaction with the quality of sapta pesona in the Cihampelas tourist area. The research data was collected by distributing a research questionnaire filled out by tourists in the tourist area of Cihampelas Bandung. Respondents as research samples were taken using accidental sampling techniques. The number of samples in this study was determined using the Lameshow formula, with a confidence level of 95% and a sampling error of 10%. Descriptive analysis is used to analyze data by describing or describing data that has been collected, while to see the level of tourist satisfaction with the Cihampelas Bandung tourist area, Likert scale assistance is used. To make it easier to describe and interpret the variables studied, descriptive statistical processing is carried out. The calculated average value is used as a reference to determine the classification of assessment categories. The results of the study found that sapta pesona has been applied in the tourist area of Cihampelas Bandung with the level of tourist satisfaction with the 7 aspects of sapta pesona is good with a value of 3.92 according to the average assessment of the level of satisfaction. Another finding is that male travelers expressed more good and excellent ratings compared to female travelers.
Inoculation with a selected strain of Metschnikowia pulcherrima as a bioprotective alternative to sulphites for preventing browning of white grape must
Authors: Bustamante Marco , Giménez Pol , Just-Borràs Arnau , Solé-Clua Ignasi , Gombau Jordi , Heras José M. , Sieczkowski Nathalie , Gil Mariona , Canals Joan M. , Zamora Fernando
Published: March 2024

In this study, the effectiveness of a selected strain of Metschnikowia pulcherrima (MP1) was compared to that of sulphur dioxide for preventing white grape must from browning. Sulphur dioxide was found to drastically reduce oxygen consumption rate, protect hydroxycinnamic acids against oxidation and prevent grape must from browning, even in the presence of laccase. By contrast, supplementation with the selected strain of Metschnikowia pulcherrima (MP1) drastically increased oxygen consumption rate, thus reducing the amount of oxygen available for polyphenol oxidases. In the absence of laccase, this resulted in a decrease in browning and a certain degree of protection of the hydroxycinnamic acids, but in the presence of laccase it was not effective enough. Consequently, the selected strain of Metschnikowia pulcherrima (MP1) can be considered an interesting alternative to sulphur dioxide for preventing browning in white grape must, but only in conditions of healthy grapes.
Interferonopathies in atypical chronic active herpesvirus infections: a treatment strategy for interferon deficiency
Authors:   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Nesterova I.V. , Khalturina E.O. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Malinovskaya V.V. ,   N.F.Gamaleya National Research Centre for Epidemiology and Microbiology, Moscow, Russian Federation
Published: March 2024

A cytokine imbalance and interferonopathies associated with deficits of type I and type II interferons (IFN) are often observed in atypical chronic active herpesvirus infections (ACA-HVI). Objective. To study the features of IFN system functioning and cytokine profile in patients with ACA-HVI before and after the immune system correction integrative program (ISCIP) including local and systemic interferon therapy. Patients and methods. A total of 39 male and female patients aged 23–70 years with ACA-HVI characterized by isolated disorders in the IFN system were examined. The study included the following methods for herpesvirus detection: serodiagnostics and a real-time polymerase chain reaction (RT-PCR). The cytokine profile (interleukins IL-1β, IL1Ra, IL-6, IL-17) and the IFN system were analyzed by an enzyme-linked immunosorbent assay (ELISA). The study was approved by the Ethics Committee, and an informed consent was obtained from all patients. Results. Patients with ACA-HVI had antiviral immune response disorders. Against the background of serum IFN deficiency, induced and spontaneous production of IFNα and IFNγ, a functional impairment of cytokine profile with predominant hyperproduction of proinflammatory cytokines IL-1β, IL-6, tumor necrosis factor-α were revealed. Positive clinical and immunological effects of ISCIP were demonstrated. It was shown that IL1Ra can be used as a diagnostic biomarker to monitor the course and outcome of ACA-HVI. Conclusions. The developed ISCIP with the inclusion of targeted local and systemic interferon therapy for patients with ACAHVI demonstrated high clinical and immunological efficacy against the background of the confirmed absence of anti-IFNα autoantibodies. Key words: herpesvirus infections, interferonopathies, neutrophil granulocytes, interferon system
State Medicaid Initiatives Targeting Substance Use Disorder in Criminal Legal Settings, 2021
Authors: Lewis Cashell D. , Andrews Christina , Abraham Amanda J. , Westlake Melissa , Taxman Faye S. , Grogan Colleen M.
Published: March 2024

Objectives. To document state Medicaid pre- and postrelease initiatives for individuals in the criminal legal system with substance use disorder (SUD).

Methods. An Internet-based survey was sent in 2021 to Medicaid directors in all 50 US states and the District of Columbia to determine whether they were pursuing initiatives for persons with SUD across 3 criminal legal settings: jails, prisons, and community corrections. A 90% response rate was obtained.

Results. In 2021, the majority of states did not report any targeted Medicaid initiatives for persons with SUD residing in criminal legal settings. Eighteen states and the District of Columbia adopted at least 1 Medicaid initiative for persons with SUD across the 3 criminal legal settings. The most commonly adopted initiatives were in the areas of medication for opioid use disorder treatment and Medicaid enrollment. Out of 24 possible initiatives for each state (8 initiatives across 3 criminal legal settings), the 2 most commonly adopted were (1) provision of medication treatment of opioid use disorder before release from criminal legal settings (16 states) and (2) facilitation of Medicaid enrollment through suspension rather than termination of Medicaid enrollment upon entry to a criminal legal setting (14 states). Initiatives pertaining to Medicaid SUD care coordination were adopted by the fewest (9) states.

Conclusions. In 2021, states’ involvement in Medicaid SUD initiatives for criminal legal populations remained low. Increased adoption of Medicaid SUD initiatives across criminal legal settings is needed, especially knowing the high rate of overdose mortality among this group. ( Am J Public Health. 2024;114(5):527–530. https://doi.org/10.2105/AJPH.2024.307604 )
Do Transtibial Amputations Outperform Amputations of the Hind- and Midfoot Following Severe Limb Trauma?
Authors: Fram Brianna R. , Bosse Michael J. , Odum Susan M. , Reider Lisa , Gary Joshua L. , Gordon Wade T. , Teague David , Alkhoury Dana , MacKenzie Ellen J. , Seymour Rachel B. , Karunakar Madhav A. ,   The Major Extremity Trauma Research Consortium
Published: March 2024

Background:

The purpose of this study was to compare 18-month clinical and patient-reported outcomes between patients with severe lower-limb injuries treated with a transtibial amputation or a hind- or midfoot amputation. Despite the theoretical benefits of hind- and midfoot-level amputation, we hypothesized that patients with transtibial amputations would report better function and have fewer complications.

Methods:

The study included patients 18 to 60 years of age who were treated with a transtibial amputation (n = 77) or a distal amputation (n = 17) and who were enrolled in the prospective, multicenter Outcomes Following Severe Distal Tibial, Ankle, and/or Foot Trauma (OUTLET) study. The primary outcome was the difference in Short Musculoskeletal Function Assessment (SMFA) scores, and secondary outcomes included pain, complications, amputation revision, and amputation healing.

Results:

There were no significant differences between patients with distal versus transtibial amputation in any of the domains of the SMFA: dysfunction index [distal versus transtibial], 31.2 versus 22.3 (p = 0.13); daily activities, 37.3 versus 26.0 (p = 0.17); emotional status, 41.4 versus 29.3 (p = 0.07); mobility, 36.5 versus 27.8 (p = 0.20); and bother index, 34.4 versus 23.6 (p = 0.14). Rates of complications requiring revision were higher for distal amputations but not significantly so (23.5% versus 13.3%; p = 0.28). One distal and no transtibial amputees required revision to a higher level (p = 0.18). A higher proportion of patients with distal compared with transtibial amputation required local surgical revision (17.7% versus 13.3%; p = 0.69). There was no significant difference between the distal and transtibial groups in scores on the Brief Pain Index at 18 months post-injury.

Conclusions:

Surgical complication rates did not differ significantly between patients who underwent transtibial versus hind- or midfoot amputation for severe lower-extremity injury. The average SMFA scores were higher (worse), although not significantly different, for patients undergoing distal compared with transtibial amputation, and more patients with distal amputation had a complication requiring surgical revision. Of note, more patients with distal amputation required closure with an atypical flap, which likely contributed to less favorable outcomes.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Field testing of abundance estimation methods for monitoring mammals in tropical mountainous forests: a case study of Simbalbara Wildlife Sanctuary and Churdhar Wildlife Sanctuary, Himachal Pradesh, India
Authors: Singh Nidhi , Bhatt Urjit , Chaudhary Saurav , Lyngdoh Salvador
Published: March 2024

Information on the status and population estimates of species within a geographical area is vital for developing effective conservation plans. Camera traps have emerged as a promising cost-effective tool, for which numerous methods for estimating population density have been reported. Comparative tests of their applicability and performance, on the other hand, are scarce. Camera-trapping and line-transect surveys were conducted in Simbalbara Wildlife Sanctuary (SWLS) and Churdhar Wildlife Sanctuary (CWLS) to test different methods, i.e., spatially capture-recapture sampling (SECR), camera-trap distance sampling (CTDS), line transect distance sampling (LTDS), for determining species richness and density of various mammalian fauna. Camera traps recorded fifteen and twelve mammals in SWLS and CWLS, respectively. In SWLS, sambar had the highest ungulate density with 5.0 and 5.3 individuals/km2 estimated by LTDS method and CTDS method, respectively. These two methods generated a similar population for most ungulate species, indicating that both methods may be applicable in mountainous habitats. The study discusses various approaches for estimating density for identifiable and unidentifiable individuals in rugged terrain. Our findings suggest that all tested methods can work well, with each having its own strengths and weaknesses.
Machine Learning vs. Rule-Based Methods for Document Classification of Electronic Health Records within Mental Health Care - A Systematic Literature Review
Authors: Rijcken Emil , Zervanou Kalliopi , Mosteiro Pablo , Scheepers Floortje , Spruit Marco , Kaymak Uzay
Published: March 2024

Document classification is a widely used approach for analysing mental healthcare texts. This systematic literature review focuses on document classification in healthcare notes obtained from electronic health records within mental health care. We observe that the last decade has been characterized by a shift from rule-based methods to machine-learning methods. However, while the shift towards machine-learning methods is evident, there is currently no systematic comparison of both methods for document classification in applications in mental healthcare. In this work, we perform a systematic literature review to assess how these methods compare in terms of performance, which are the specific applications and tasks, and how the approaches have developed throughout time. We find that for most of the last decade, rule-based methods have performed better than machine-learning methods. However, recent developments towards healthcare data availability in combination with self-learning neural networks and transformer-based large language models result in higher performance.
“Investigating the Influence of Ages on the Preparation and Validation Performance of MLP
Authors: SHAFIQUL-ABIDIN SHAFIQUL-ABIDIN , IZHAR MOHD. , SAWHNEY RUCHI , Haider Haider Abbas
Published: March 2024

This research explores the impact of varying the number of training epochs on the performance of a multilayer perceptron (MLP) applied to MNIST handwritten digit classification. MNIST, a benchmark dataset in machine learning, comprises grayscale images of digits 0–9. The investigation employs PyTorch as the deep learning framework, delving into the intricacies of MLP training through an iterative process. The study systematically adjusts the number of training epochs to probe the hyperparameter's influence on MLP convergence and generalization capabilities. Conducted experiments involve training the MLP with different epoch counts while monitoring training and validation accuracies. Results are meticulously analyzed to unveil patterns in model performance, with a focus on identifying optimal epochs that strike a balance between underfitting and overfitting. The research yields valuable insights into the optimal training duration for MLPs in MNIST digit classification. This newfound knowledge offers practical guidance for practitioners in selecting appropriate hyperparameters during MLP training. The implications extend to enhancing model performance and generalization for analogous image classification tasks, contributing to the broader field of machine learning.
PEAK End-Tidal NO as a biomarker for investigating the effect of different OLV strategies on lung injury and inflammation response.
Authors: zhang rui , Jiang shangye , wang dongchun , pi xin
Published: March 2024

One-lung ventilation (OLV) aggravates alveolar damage and inflammation response in the lung. The evaluation indicators of lung injury caused by OLV are not perfect. End-tidal fraction of nitric oxide (ETNO) continuously collected during ventilation may be a new and non-invasive inflammatory marker of lung injury to investigate the effect of different OLV strategies. A total of 56 patients undergoing thoracic surgery were included and randomized into two groups. These patients had the same parameters during two-lung ventilation, but during OLV, the High-Volume group was set at a tidal volume (VT)=8 ml/kg predicted body weight (PBW) and a positive end-expiratory pressure (PEEP)=5 cmH2O, while the Low-Volume group was set at a VT=5 ml/kg PBW and a PEEP=5 cmH2O with recruitment every 30 min. ETNO was acquired at the points of induction, OLV 0 min, OLV 15 min, OLV 30 min, OLV 1 h and immediately at two-lung re-ventilation. We also obtained traditional evaluation indicators at the same points. ETNO did not differ significantly between groups at baseline. When the patients suffered OLV, compared with the Low-Volume group, ETNO in the High-Volume group significantly decreased at all points (P<0.001), and the expression of endothelial NO synthase in plasma decreased but lagged for a quarter. There was almost no change in traditional inflammatory factor in plasma. Compared with traditional inflammatory factor, ETNO can be a new, rapid, convenient and accurate inflammatory marker for investigating the effects of different OLV strategies in early-phase lung injury and pro-inflammation response.
Clinical trial registration.ChiCTR1800015993
Location of a municipal solid waste landfill using COCOSO, MAIRCA, MARCOS, and geographic information system (case study: Yazd)
Authors: Tafti Maedeh Dehghani , Monavari Seyed Masoud , Dehabadi Abolghasem Mirhoseini , Karbassi Abdolreza
Published: March 2024

Waste disposal is becoming a big global problem. Given the increasing human activities, solid waste causes serious damage to the ecosystem and human health. The illegal disposal of municipal solid waste (MSW) in unacceptable places can cause serious damage to the environment. Therefore, this study was conducted to prioritize the located municipal solid waste landfill (MSWLF) and provide policies and methods to reduce this problem in 2021 in Yazd. Since location is a time-consuming and multi-faceted process. with the involvement of different parameters, the opinion of experts, information references and multi-purpose evaluation methods is required. Therefore, in this descriptive study, using the Delphi method, the criteria for locating arid regions were specified and to analyze the data collected by descriptive and inferential statistics, such as Kolmogorov-Smirnov, were used to determine the causal relationship between variables using the structural equation modeling by SPSS. Kendall's W was used to confirm the correlation and agreement of the opinions. Using the system Geographic information (GIS) and Boolean logic, a map of suitable MSWLF was prepared. COCOSO, MAIRCA and MARCOS were used as multi-criteria decision making (MCDM) to prioritize the most suitable MSWLF in Yazd. The results showed that complete agreement between the results of MARCOS, MAIRCA and COCOSO. The results of MCDM showed that A7 had better conditions for MSW disposal due to its features such as far from residential areas and agricultural lands, suitable slope and road. So that it was suggested as the most suitable site for the next 20 years as v in Yazd, and according to the study results on the small percentage of areas suitable for MSWLF in arid and desert regions, considering ZeroWaste strategies in the comprehensive waste management plans of arid and desert regions because of sensitive and fragile ecosystem.
InSAR based Investigation of Ground Subsidence due to Excavation – A case study of Incheon City, South Korea
Authors: Park Kyungwon , Kim Yong Je , Nam Boohyun
Published: March 2024

Ground subsidence is one of geohazards, particularly in urban environment due to its negative impact to nearby buildings and civil infrastructures. This study investigates the amount and spatial distribution of ground subsidence in Incheon City, South Korea, where ground excavation was made. Interferometric Synthetic Aperture Radar (InSAR) was used to monitor surface deformation around the excavation site. The study analyzed subsidence during an excavation project using Sentinel-1b satellite data, and the InSAR results were compared with traditional leveling methods and field measurements. Notable subsidence during the early construction phase was identified, which demonstrates the effectiveness of InSAR in urban environment. The research contributes to understanding of the excavation-inducing ground subsidence due to the reclamation layer.
Impact of metformin, statin, aspirin and insulin on the prognosis of uHCC patients receiving first line Lenvatinib or Atezolizumab plus Bevacizumab
Authors: Rimini Margherita , Montes Margarida , Amadeo Elisabeth , Vitiello Francesco , Kudo Masatoshi , Tada Toshifumi , Suda Goki , Shimose Shigeo , Lonardi Sara , Finkelmeier Fabian , Salani Francesca , Antonuzzo Lorenzo , Marra Fabio , Iavarone Massimo , Cabibbo Giuseppe , Foschi Francesco Giuseppe , Silletta Marianna , Sacco Rodolfo , Rapposelli Ilario Giovanni , Scartozzi Mario , Nicoletta Pella , Aldrighetti Luca , Persano Mara , Camera Silvia , Rossari Federico , Foti Silvia , Kumada Takashi , Hiraoka Atsushi , Iwamoto Hideki , Rizzato Mario Domenico , Himmelsbach Vera , Masi Gianluca , Corradi Mattia , Celsa Ciro , Conti Fabio , Frassineti Giovanni Luca , Cascinu Stefano , Casadei-Gardini Andrea , Presa Jose
Published: March 2024

INTRODUCTION: Recently, in Hepatocellular carcinoma (HCC) setting, the use of metformin has been associated to a trend toward worse response rate, overall survival and progression free survival in patients who received immunotherapy.
METHODS AND MATERIAL: The study population included individuals from both Eastern and Western regions with a confirmed diagnosis of HCC and receiving first line treatment with atezolizumab plus bevacizumab or lenvatinib. Univariate and multivariate analyses were performed by Cox proportional. For the analysis, patients were stratified based on their use of concomitant medication or not.
RESULTS: At the time of database lock, 319 deaths were observed: 209 in the Lenvatinib cohort, 110 in the Atezolizumab plus bevacizumab cohort. In the Atezolizumab plus Bevacizumab arm, 50 (16.5%) patients were on chronic metformin use. At the univariate analysis for OS, patients who used metformin showed significantly shorter OS compared to patients who did not use metformin (HR 1.9, 95% CI 1.1-3.2). Multivariate analysis confirmed that patients in metformin group had significantly shorter OS compared to patients in no-metformin group (HR 1.9; 95% CI, 1.1-3.1). At the univariate analysis for PFS, patients in metformin group had significantly shorter PFS compared to patients in no-metformin group (HR 1.6, 95% CI 1.0-2.6). Multivariate analysis confirmed that patients in metformin group had significantly shorter PFS compared to patients in no-metformin group (HR 1.7; 95% CI, 1.1-2.7; p=0.0147). No differences were reported in terms of ORR and DCR between patients in metformin group and those in no-metformin group. In the Lenvatinib cohort, 65 (15%) patients were recorded to chronically use metformin. No statistically significant differences in terms of both OS and PFS were found between patients in metformin group and patients in no-metformin group .
CONCLUSION: This analysis unveils a negative prognostic role associated with metformin use specifically within the Atezolizumab plus Bevacizumab group.
EIA in Strengthening Law Enforcement and Penalties: A Case of Corruption in Natural Resource Sector for Indonesia
Authors: Sasongko Mochamad Agung , Mizuno Kosuke , Utomo Suyud Warno , Koestoer Raldi Hendrotoro Seputro
Published: March 2024

Corruption in Indonesia's natural resource sector is a significant issue with far-reaching consequences for environmental sustainability. Despite the detrimental effects of corrupt practices on the environment, law enforcement penalties for corruption often fail to compensate for their environmental impact. The aim of the study is to explore how the use of Environmental Impact Assessments (EIAs) strengthen law enforcement efforts and increase penalties for corrupt practices in Indonesia's natural resource sector. The method used is to collect and analyze regulations, policies, and corruption study cases to examine the relationship between EIA and corruption penalties. The results showed that EIA can help corruption cases investigation and corruption cases involving EIA receive heavier penalties. This study concluded that the Indonesian government needs to reformulate its law enforcement approach by incorporating EIA into corruption investigations and using more severe penalties to deter corruption in the natural resource sector.
Liquid metal interface mechanochemistry disentangles energy density and biaxial-stretchability tradeoff in composite capacitor film
Authors: Wu Kai , Xie Zilong , Zhu Jianan , Dou Zhengli , Zhang Yongzheng , Wang Ke , Fu Qiang
Published: March 2024

Dielectric polymer composites for film capacitors have advanced significantly in recent decades, yet their practical implementation in industrial-scale, thin-film processing faces challenges, particularly due to limited biaxial stretchability. Here, we introduce a mechanochemical solution that applies liquid metal onto rigid dielectric fillers (e.g. boron nitride), dramatically transforming polymer-filler interface characteristics. This approach significantly reduces modulus mismatch and stress concentration at the interface region, enabling polypropylene composites to achieve biaxial stretching ratio up to 450×450%. Furthermore, liquid metal integration enhances boron nitride's dielectric polarization while maintaining inherent insulation, producing high-dielectric-constant, low-loss films. These films, only microns thick yet quasi square meters in area, achieve a 55% increase in energy density over commercial biaxially-oriented polypropylene (from 2.9 to 4.5 J cm-3 at 550 MV/m), keeping 90% discharge efficiency. Coupled with improved thermal conductivity, durability, and device capacitance, this distinctive interface engineering approach makes these composites promising for high-performance film capacitors.
Magnetic activated carbon derived from pine fruit waste: efficient adsorbent for tetracycline (TC) and paracetamol (PC) removal from aqueous solution
Authors: Hashemzadeh Farzad , Ariannezhad Maryam , Derakhshandeh Seyed Hamed
Published: March 2024

This work presents a significant highly porous activated magnetic carbon nanoparticles (MPFRC-A) derived from pine fruit residue through physical activation (carbonization temperature: 110–550◦C), chemical activation (H2SO4 (0.1 N, 96%)), and Co-precipitation processes and then using it for removing tetracycline (TC) and paracetamol (PC) from water and evaluating via the spectrophotometer (DR6000). Functionalization of Fe3O4 nanoparticles on the surface of (PFR-AS) generated high saturation magnetization that causes to separate from aqueous solution by an external magnet. MPFR-AS adsorbent was evaluated by Brunauer-Emmet-Teller (BET) analyzer, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-Ray diffraction analysis (XRD) and Raman spectroscopy (RM). In the experimental sector, the effect of different items including, pH, contact time, initial concentrations, adsorbent dosage, and temperature on the adsorption processes were investigated and based on them the adsorption isotherm modules, and kinetics were studied and concluded. Results indicated that MPFR-A exhibited a large specific surface area (182.5 m2/g) and high total pore volume (0.33 cm3/g). The maximum adsorption capacity was obtained at pH = 4,5, adsorbent dose: 400 mg and initial concentration of 20 mg/L at 25°C. The study showed that experimental data were well-fitted by Langmuir isotherm model (R2 > 0.98) and the maximum uptake capacities for TC was 43.75 mg/g and for PC was 41.7 mg/g.
Delineation of groundwater potential zones using multi- criteria analysis (AHP), Frequency Ratios (RF), remote sensing and GIS: a case study of the Batcham municipality (West Cameroon)
Authors: Adama AMAYA , Juscar Ndjounguep , Mama NTOUMBE , Tsoptie TCHINDA , Rachida BENDAOUD , Elvis KAH
Published: March 2024

This study uses the methods of multi-criteria analysis (AHP) and Frequency Ratios (FR) to identify areas of high groundwater potential in order to facilitate the implementation of boreholes and help decision-makers improve access to drinking water in the Batcham municipality. The database used is made up of geological data, hydroclimatic data, well data, and satellite images. Each of the methods used is based on the study of the relationships between the factors controlling the groundwater potential. Among these factors, ten (10) were retained on the basis of previous work; these are: slope, elevation, land use, land cover, lineament density, drainage density, topographic wetness index, curvature, geology, rainfall, and the static water level. The AHP allowed, according to the user's expertise, to assign weights to each factor controlling the water potential. The FR made it possible to study the relationships linking each variable with high flow rates. The thematic layers obtained were integrated into a GIS environment to generate the groundwater potential map. Four classes of groundwater potential have been identified: bad, moderate, good, and excellent. The bad classes represent 8.32% and 11.21%; moderate 36.57% and 28.70%; good 43.55% and 38.93%; and excellent 11.56% and 21.16%, for the AHP and FR models, respectively. The overlying of wells with high flow rates on areas of excellent groundwater potential shows perfect concordance, which validated the final map. The result map was also validated by sensitivity curve analysis, and the receiver operating characteristic (ROC) curve from which result accuracy was obtained is 70.63% and 80.28% for the AHP method and FR method, respectively. The maps obtained can help decision-makers choose appropriate sites for groundwater research and for drilling boreholes.
Sociomarkers and Connectomes: Neurodevelopmental Imprints in Adolescent Brains
Authors: Shin Eun Kyong , Kang Eunsong , Lee Jiwon , Yun Byungyeon , Cha Jiook , Suk Heung-Il
Published: March 2024

Neural consequences of social disparities are not yet rigorously investigated. How socioeconomic conditions influence children’s connectome development remains unknown. This paper endeavors to gauge how precisely the connectome structure of the brain can predict an individual’s social environment, thereby inversely assessing how social influences are engraved in the neural development of the adolescent brain. The analysis has been performed over an integrated dataset consisting of brain imaging data and household level socioeconomic conditions from the Adolescent Brain and Cognition Development (ABCD) data (9,099 children residing in the United States) - and local poverty prevalence and neighborhood education level from the US census data. Using this uniquely integrated database, we found that social conditions both at the household and neighborhood levels are significantly associated with specific neural connections. Solely with brain connectome data, we train a linear support vector machine (SVM) to predict socioeconomic conditions of those adolescents. Hispanic participants achieved higher accuracy rates than White and African American children, except for the household Income level. Hispanic participants exhibited the highest accuracy rate of 0.71 and the best AUPRC of 0.77 for predicting neighborhood level educational attainment. Accuracy 0.85 for the household income and neighborhood education dual combination cases and 0.81 for the household education and neighborhood education dual condition. Furthermore, we identified 8 significant connections that critically contribute to predicting social environments in the parietal lobe and frontal lobe. Insights into social factors that contribute to early brain connectome development is critical to mitigate the disadvantages of children growing up in unfavorable neighborhoods.
Assessment of the environmental quality of areas used for sport and leisure in a city undergoing an accelerated urbanization process (Fortaleza, Brazil)
Authors: Rocha Camille , Marques Elissandra , Ramos Fernanda , Souza Oscarina , Carvalho Fátima , Nascimento Ronaldo , Zanella Maria , Cavalcante Rivelino
Published: March 2024

The expansion of cities results in serious environmental impacts, such as a reduction in green spaces, noise pollution, atmospheric pollution and thermal discomfort. Good urban environmental quality requires adequate public spaces for use by the population and well-distributed green areas throughout the city. Therefore, the aim of the present study was to assess the environmental quality of seven areas used for leisure and sport in a city that is going through an intense process of urbanization through multi-indicators such as biological (fungi and bacteria), chemical (particulate matter, carbonyl compounds) and physical (noise and thermal comfort). Collections were performed in two main seasonal periods (wet and dry), in the morning and afternoon, on weekdays and on weekends for the analysis of multi-indicators. The results revealed considerable differences in the variables measured among the different sites, indicating that location and the characteristics of each area are fundamental to the definition of environmental quality. Seasonality also exerted a considerable influence on all variables studied. The factors that most influenced this result were: flow of vehicles (greater in the afternoon and during the week), presence of vegetation in the place and building density close to the points. Most of the areas presented a high cancer risk for formaldehyde, when compared to the limits set by regulatory agencies, and three areas presented a higher risk to their users in terms of PM.
How Tourists ‘Escaping the Heat’ May Drive Future Increases in Municipal Water Demand in Oregon Coastal Communities
Authors: Rupp David E. , Dundas Steven J. , Mazaud Laura C. , de Szoeke Suzanne
Published: March 2024

Little is known about the effect of future weather and climate on municipal water demand in coastal communities with tourist-centric economies. To address this knowledge gap, we used an econometric model of monthly water demand that allowed for non-linear responses to weather variables to estimate temperature-response functions for demand from a sample of communities in the Oregon Mid-Coast. A main result is that local temperature was not a significant driver of variability in monthly water demand but that temperature in the Willamette Valley – the source of most tourists to the Oregon coast – was. We assumed that the increase in demand in response to higher Willamette Valley temperature arose from an increase in tourists escaping the heat in the Willamette Valley for cooler conditions on the coast. Applying the temperature response functions to scenarios of future climate to the year 2070 led to projected increases in water demand independent of other factors. Whether future tourism is either constrained by the local resident population that serves tourism or is constrained by the potential tourist population in the Willamette Valley, the climate-change contribution to projected water demand is generally of comparable magnitude to – if not greater than – the contribution from resident population change alone over the next fifty years. For communities where the population is projected to decline, the climate effect may more than offset the effect of declining population, resulting in a net positive change in demand.