bluuebunny/crossref_metadata_2025 huggingface dataset:
NILAI-NILAI SILA PERSATUAN INDONESIA DALAM KEBERAGAMAN KEBUDAYAAN INDONESIA
Authors: Fitri Lintang Fitri Lintang , Ulfatun Najicha Fatma
Published: July 2022

Negara Indonesia dianugerahi oleh Yang Maha Esa dengan kekayaan dan keanekaragaman budaya. Indonesia adalah negara kepulauan. Dengan jumlah pulau lebih dari ribuan ini dihuni oleh masyarakat yang memiliki suku, ras, agama, dan etnis yang berbeda-beda. Hal inilah yang membuat Indonesia memiliki keberagaman kebudayaan. Masyarakata Indonesia harus mampu hidup berdambingan antara satu dengan yang lainnya. Anugerah yang diberikan ini seharusnya disyukuri karena dapat menjadi satu kekuatan dan kebanggaan bagi Indonesia. Namun, keberagaman tersebut juga dapat menjadi ancaman, tantangan, dan gangguan bagi bangsa Indonesia. Melalui studi literatur kita dapat mengetahui bagaimana sila Pancasila yakni sila ketiga menjadi dasar pemersatu dalam keberagaman budaya. Penelitian ini menggunakan metode penelitian pustaka. Dengan pendekatan kualitatif yakni studi literatur pengumpulan informasi dengan mengkaji sumber-sumber yang terkait dengan Pancasila dan keberagaman kebudayaan Indonesia. Dari hasil studi literatur dapat disimpulkan bahwa nilai-nilai sila Persatuan Indoensia dalam keberagaman budaya Indonesia yakni menumbuhkan sikap nasionalisme, menumbuhkan sikap toleransi, saling menghormati dan menghargai perbedaan, serta membina persatuan dan kesatuan dalam keberagaman.
Analisis Literatur Sosiologi Keluarga Sakinah dalam Kewajiban Mendidik Anak Usia Dini
Authors: Saputra Agung , Muslim Imam , Yuniarto Bambang , Mulyana Asep
Published: July 2022

Kajian ini difokuskan pada relasi agama, keluarga dan negara tentang penerapan keluarga sakinah di Indonesia dan dampaknya terhadap kewajiban pendidikan anak usia dini. Atas dasar agama, pemerintah meligitimasi ide keluarga sakinah dalam pembentukan keluarga muslim melalui pernikahan. Ketentraman dalam kasih sayang sebagai landasan hubungan pengasuhan keluraga pada anak telah dimulai sejak masa janin bisa memberikan pengaruh positif terhadap keberlanjutan masa depan yang lebih baik. Semua itu dimaksudkan agar keseimbangan negara dapat terbangun dari unit terkecil di dalamnya, yaitu keluarga tentram penuh dengan kasih sayang.
PENERAPAN QUALITY FUNCTION DEPLOYMENT DALAM PENINGKATAN KUALITAS LAYANAN PERPUSTAKAAN PERGURUAN TINGGI
Authors: Herman Herman , Amrina Elita , Bora M. Ansyar
Published: July 2022

Perpustakaan Fakultas Teknik Universitas Ibnu Sina (UIS) mempunyai fasilitas layanan fisik maupun non fisik seperti keramahan petugas, kelengkapan buku, skripsi, laporan, fasilitas meja baca. Dari layanan tersebut mahasiswa masih merasa belum puas dikarenakan waktu layananya terbatas, referensi buku tentang kejuran masih minim, waktu peminjaman buku sangat singkat, tingginya denda keterlambatan dalam pengembalian buku. Sehingga dapat mempengaruhi dari minat baca mahasiswa, berdasarkan data minat baca selama 3 tahun mulai dari tahun 2017-2019 yaitu jumlah rata-rata pertahun 308 orang dari total mahasiswa aktif sebanyak 1247 orang, dengan rata-rata persentase setiap tahun hanya 24,7%. Berdasarkan dari permasalah tersebut maka diperlukan metode Quality Function Deployment (QFD) untuk mendesain perbaikan kualitas layanan perpustakaan di Fakultas Teknik Universitas Ibnu Sina (UIS) agar dapat memenuhi kepuasan mahasiswa. Dari hasil pengukuran yang telah dilakukan menunjukkan bahwa mahasiswa masih merasa belum puas dikarenakan semua dimensi layanan mengahasilkan nilai negatif, nilai dimensi gap terbesar adalah dimensi tangible dengan nilai -6,05 kemudian disusul dimensi reliability dengan nilai Gap -5,64. Sedangkan hasil penyusunan matrix house of quality (HoQ) desain untuk perbaikan layanan perpustakaan dengan prioritas utama adalah melakukan training terhadap petugas perpustakaan dengan nilai bobot 81, kemudian yang kedua yaitu menyediakan fasilitas layanan yang memadai dengan nilai bobot 58.
Estrategias de cortesía verbal en anuncios de parejas publicados en un semanario ecuatoriano
Authors: Araujo-Bilmonte Elking , Naranjo-Tipán Yamislaydis , Garcés-Bucheli Deifilia
Published: July 2022

La cortesía verbal comprende un conjunto de recursos lingüísticos empleados con distintos fines por los hablantes en sus intercambios comunicativos. Una de las situaciones de habla en las que la cortesía verbal juega un papel fundamental es el cortejo. En ese espacio de interacción, el buscar atraer al otro para establecer un vínculo afectivo obliga a cuidar la imagen propia, la imagen del otro y, al mismo tiempo, reforzar los recursos de seducción. Los anuncios de pareja forman parte de estos territorios de interacción donde la cortesía verbal ofrece un catálogo representativo de las normas que rigen la sociedad a la que pertenecen los interlocutores y los recursos que estos conocen. A fin de establecer estas estrategias lingüísticas en los anuncios de pareja, se construyó un corpus con los anuncios publicados en el semanario dominical “Familia” del periódico “El Comercio”, en la sección “Corazones solitarios” durante el año 2020. Los anuncios fueron divididos en dos grupos según se autoidentificaran los anunciantes como hombres o mujeres. Las estrategias fueron etiquetadas y clasificadas según las últimas propuestas teóricas. Los resultados evidencian que las estrategias empleadas están determinadas por las características discursivas del anuncio de pareja, que el conjunto de tipologías empleadas es menor a la propuesta por la teoría y que, dentro de las estrategias, se aprecia un uso preferente por la tipología de la impersonalización, la autorreferenciación en tercera persona, el uso de vocativos y el empleo del condicional como atenuador en actos directivos.
Comunidades de aprendizaje y nuevas tecnologías
Authors: Núñez-Hernández Corina , Larco-Pullas Jenny , Ayala-Jaramillo Karina
Published: July 2022

Las comunidades de aprendizaje conjuntamente con el uso adecuado de las nuevas tecnologías abren las puertas a una educación virtual actualizada por la pandemia de COVID-19 que azota el mundo entero, el objetivo que se pretende alcanzar es la formación propia de cada estudiante con la intervención familiar y social, acorde a su propio contexto. Se debe entender que las nuevas tecnologías tienen un gran potencial en el proceso educativo y la intervención de las familias es muy importante para su integración al formar equipos de trabajo en la búsqueda de la transformación educativa, cuya práctica facilita la toma de decisiones en conjunto entre profesores, padres y alumnado para mejorar los procesos y seguir mejores caminos para la consecución de objetivos académicos. Durante los últimos meses la tecnología ha tomado fuerza en la construcción colaborativa y colectiva del aprendizaje, debido a que facilitan la generación de espacios que propician el intercambio de ideas y responden a las necesidades académicas, se ha conseguido definir reglas de participación para toda la comunidad educativa que por ahora se ha convertido en una comunidad virtual de aprendizaje, permitiendo abordar los contenidos desde diferentes perspectivas.
ХМАРООРІЄНТОВАНІ ТЕХНОЛОГІЇ НАВЧАННЯ ЯК ІНСТРУМЕНТ СИСТЕМИ ЦИФРОВОЇ ПІДГОТОВКИ МЕНЕДЖЕРІВ
Authors: Бодненко Дмитро Миколайович , Яковенко Ігор Валентинович , Кучаковська Галина Андріївна , Локазюк Олександра Вікторівна
Published: July 2022

У статті розглянуто теоретичні та прикладні аспекти застосування хмарних технологій навчання та соціальних мереж у системі організації та проведення тренінгів для менеджерів середньої ланки. Застосування зазначених технологій та мереж були показані на прикладі підготовки менеджерів, що працюють у страховому бізнесі. Для дослідження був взятий важливий аспект системи менеджменту – формування та забезпечення зворотного зв’язку в управлінській діяльності засобами ІКТ. Під час дослідження проаналізовано використання хмаро орієнтованих технологій при цифровій підготовці менеджерів до організації та забезпечення оцінки зворотного зв’язку від клієнтів страхових компаній – страхувальників, сформульовано та розкрито рекомендації щодо проведення навчання з метою підвищення ефективності оцінки зворотного зв’язку. Наведено приклади хмарних сервісів та соціальних мереж для створення, аналізу та використання опитувань. Розкрито доцільність використання цифрової підготовки, а також структуру і контент моделі «Використання хмаро орієнтованих технологій навчання для цифрової підготовки менеджерів із урахуванням оцінки зворотного зв’язку». Також обґрунтовано та розроблено хмаро орієнтовану технологію проведення тренінгу для цифрової підготовки менеджера до визначення впливу оцінки зворотного зв’язку на якість роботи управлінського персоналу. Для забезпечення обробки статистичних даних опитувань проведено перевірку через електронні таблиці Microsoft Excel, зокрема за допомогою пакету аналізу Analysis ToolPak, графіків та діаграм. Розкрито зміст кожного з етапів тренінгу та окремих складових цих етапів, які поєднують у собі підготовку менеджера до диджиталізації засобами використання хмарних сервісів та соціальних мереж та передбачають здійснення тренінгу за такими напрямами, як цифрова складова та управлінська складова. Обов’язковими до виконання і захисту є реалізація, згідно встановлених тренерами критеріїв, зворотного зв’язку, формування (та прийняття) управлінських рішень засобами хмарних сервісів та соціальних мереж. У даній роботі зазначено, що застосування хмаро орієнтованих технологій в освітньому процесі передбачає не тільки проведення тижневого тренінгу для менеджерів, а і післятренінговий моніторинг для закріплення набутих знань. Для цього було запропоновано варіант організації централізованої електронної системи отримання та опрацювання побажань клієнтів.
USE OF AN E-TEXTBOOK FOR PRE-SERVICE TEACHERS IN AUTONOMOUS LEARNING OF ENGLISH FOR SPECIFIC PURPOSES
Authors: Gurevych Roman S. , Dmitrenko Natalia Ye. , Petrova Anastasiia I. , Podzygun Olena A. , Opushko Nadiia R.
Published: July 2022

The research reveals the advantages of using an e-textbook in autonomous learning of the discipline “Foreign Language for Professional Communication (English)” by pre-service teachers of mathematics. The article presents the method of application of the ESP (English for specific purposes) e-textbook “Mathematics”, its structure, and functions. The ESP e-textbook includes learning material of three different levels of language proficiency. Each part contains professional vocabulary and speech situations aimed at forming the necessary skills and abilities in the mathematical field. The authors describe the stages of work with the learning material within a unit of the ESP e-textbook. The necessity of introduction of ESP e-textbooks in the process of learning a foreign language by pre-service teachers of mathematics is justified. The benefits of using the ESP e-textbook by students for autonomous learning are elucidated, and new opportunities for an ESP teacher to structure foreign language classes are outlined in the research. Experimental training with the use of the ESP e-textbook is conducted among pre-service teachers of mathematics at Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University (Ukraine), where the ESP e-textbook is considered as an element of the learning environment for professional creative activity and accumulation of knowledge in the conditions of autonomous learning. The study presents and analyzes the results of students’ English proficiency tests, and the survey on the students’ attitude to the use of ESP e-textbooks in the process of autonomous learning of ESP. The analysis of students’ surveys shows the effectiveness and expediency of using the e-textbook by pre-service teachers of mathematics in autonomous learning of English for professional communication. In the paper, some samples of educational activities from the ESP e-textbook “Mathematics” are presented.
Issues of trust: A thematic analysis of the lived experiences of four mothers living in Istanbul during the COVID-19 pandemic
Authors: ÖZTÜRK Nesli Bilge , YURUR Gulkizilca
Published: July 2022

The COVID-19 experience of medical professionals in Turkey is strongly determined by the absence of transparent networks to share or receive information, lack of administrative coordination and few channels for direct communication with the public. The Turkish Ministery of Health provides healthcare workers with no clear instructions on how to share pandemic-related data and the Ministery fails to make relevant public health decisions together with the active participation of medical experts working in healthcare facilities. How do these organisational and political shortcomings determine the attitudes, approaches and survival strategies of people in the daily homesetting? This qualitative study is structured around the narrative analysis of the lived experience of this group of mothers during the pandemic,where by the narratives most of all indicate a strong mistrust towards governmental authorities and private enterprises active in the provision of healthcare services. This attitude of mistrust is rooted in the actual conditions of increasing economic inequality in Turkey. The interview results indicate that a stronger cooperation and a more transparent exchange of information between government agencies and autonomous associations of medical professionals is needed to reduce fear and anxiety among the population and increase compliance to healthcare policies, especially during times of big scale public health emergencies.
A bonnacon’s defensive tactics in medieval natural history
Authors: Block Friedman John
Published: July 2022

The bonnacon, an animal described in the medieval bestiary, when pursued by hunters, squirts a cloud of boiling dung at them, wounding both dogs and men. Another bestiary animal, the onager, also used its dung in a deceptive way to avoid pursuit. These defensive tactics can be related to similar tactics reported in medieval sources for two birds, the grey heron ( Ardea cinerea) and the little bustard ( Tetrax tetrax) when attacked by hunters’ falcons. Was the fabled defensive behaviour of the bonnacon transferred to a completely different species when passing through the medium of experti, huntsmen, foresters and falconers, where the actions of animals were observed but not correctly interpreted as to cause and effect? This paper traces the bonnacon in late medieval history and studies the apparent portability of its defensive behaviour among different species.
The golden age (1862–1910) of the Zoological Section of the Museu Nacional de Lisboa (National Museum of Lisbon), Portugal
Authors: Gamito-Marques Daniel
Published: July 2022

This paper provides an overview of the organization and first decades of the Zoological Section of the Museu Nacional de Lisboa (National Museum of Lisbon), under the leadership of José Vicente Barbosa du Bocage (1823–1907), a Portuguese zoologist who attained international recognition. The article discusses the contributions made by a small community of zoologists, who joined transnational networks and gave projection to the institution by founding and disseminating the first Portuguese journal exclusively devoted to scientific research, the Jornal de sciencias mathematicas, physicas e naturaes, in which they published their original research. The animal collections of the Zoological Section were unique in that they had numerous specimens of previously unknown Southwestern African birds and reptiles, most of which were sent by José de Anchieta, who extensively travelled across the Angolan hinterland. From its inception, the museum was tied to a higher education institution, the Escola Politécnica de Lisboa (Lisbon Polytechnic School), and also fulfilled a pedagogical function. Although the Zoological Section survived the death of its founder, being renamed Museu Bocage (Bocage Museum) in 1905, it failed to gain more autonomy in subsequent decades, becoming a constrained institution that lacked premises and personnel to meet its rising demands. After a fire that destroyed almost all its specimens in 1978, the recently reformed Museu Nacional de História Natural e da Ciência (National Museum of Natural History and Science) is trying to write a new chapter by honouring its long history.
State banks during wartime: key issues and response measures
Authors:   SESE “The Academy of Financial Management”, BORTNIKOV Gennadiy , ,LYUBICH Oleksandr ,   SESE “The Academy of Financial Management”, HLADKYH Dmytro ,   National Institute for Strategic Studies
Published: July 2022

Introduction. Ukrainian banking system in general and state-owned banks in particular have faced a set of unprecedented threats, risks and challenges associated with the outbreak of open armed aggression against Ukraine. The negative consequences of hostilities were, in particular, the loss of physical access of banks and customers to some branches and payment infrastructure, the growth of defaults and the suspension of lending. Problem Statement. Improving the stability and reliability of the banking system through the intervention of the central bank and creating favorable conditions for business. Purpose. The aim is to analyze the consequences of the armed conflict on the banking sector and substantiate the list of measures to reduce or neutralize this impact. Methods. General and special methods are used: analysis, synthesis, grouping, description, comparison, theoretical generalization and abstract-logical. Results. The actions of the Government and the National Bank in martial law were generally adequate, including measures to support the most vulnerable groups, reduce tax pressure on business, stimulate business activity by providing cheap loans under a number of government programs, comprehensive support for the banking system through the refinancing mechanism, mitigation of some regulatory requirements. The war made significant adjustments to the strategy of reforming state-owned banks. The structure of households\' funds also changed due to the sudden transformation of the pattern of their behavior. State-owned banks prefer to invest in treasury bills and NBU certificates rather than lending to customers. The main reason for the restrained growth of loan portfolios can be considered a decrease in demand for loans from reliable borrowers, and increasing credit risks. Conclusions. Banks with state capital have demonstrated their financial stability, have not experienced significant withdrawals from accounts, but have preferred to lend to large corporations or provide financial support to SMEs only through government programs of concessional loans. It is expedient to develop national loan restructuring programs together with the banking community, it is time to return to the idea of creating a full-fledged development bank in Ukraine on the basis of existing state-owned banks.
Lactobacillus Species in Breast Milk: Do They Get Affected by Birth Style?
Authors: DAİF Aya , ZER Yasemin , ERİNMEZ Mehmet
Published: July 2022

Objective; Breast milk has an important function in the formation of the intestinal flora. Cesarean section bypasses the vertical transition of vaginal flora to the baby also usually causes the late start of lactation. The difference is in birth style and lactation period may affect the microbiota of breast milk. In this study, it was aimed to investigate how Lactobacillus species found in breast milk differ by the birth style and stages of milk.
Methods; Milk samples were taken from 72 mothers who had a vaginal birth (n:36) and cesarean (n:36) were divided into three groups as colostrum (n:12), early milk (n:12), and mature milk (n:12). Lactobacillus species were investigated from milk samples by real-time PCR.
Results: While Lactobacillus was detected in 70 (97.2%) of the samples, it was not detected in 2 (2.8%) of the samples taken from women with cesarean delivery. L. acidophilus and L. rhamnosus were detected simultaneously in all transitional milk samples of women who had a vaginal birth, and 82 Lactobacillus species were detected. The species identified were 33(39.3%) L. rhamnosus, 25(29.8%) Lactobacillus spp., and 24(28.6%) L. acidophilus. The rate of detection of L. acidophilus in milk samples taken from women who gave birth was found to be significantly higher than that found in milk samples taken from women who gave birth by cesarean section (p <0.05).
Conlusion: Breast milk is not only a nutritional source but an important source of probiotics. Lactobacilli were found to be concentrated in breast milk. Also, Lactobacillus species detected in breast milk may differ according to the mode of delivery.
Perceived Stress and Perceived Vulnerability at Healthcare Workers during Covid-19 Pandemic
Authors: GÖKKAYA Berna , YAZICI Tuba Nur , KARGUL Betul
Published: July 2022

Objective:This study evaluated the psychological effects of the COVID-19 pandemic on healthcare workers (HCWs) and determined several risk factors..
Methods: An online cross-sectional survey was administered to 244 HCWs recruited via the Google Docs platform. The 36-item questionnaire comprised three domains: demographic details, the Perceived Stress Scale-10 (PSS-10), and the Perceived Vulnerability to Disease Questionnaire (PVDQ).Multiple linear regression analysis was used to determine the risk factors for adverse psychological responses.
Results:Overall, 244 HCWs aged between 20 and 60 years old participated in the survey and the mean scores for perceived stress (PS), perceived infectability (PI), and germ aversion (GA) were 20.15, 28.83 and 47.78, respectively. Additionally, they were positively associated with gender. Females’ score on PS (p=0.001), PI (p=0.017), and GA were also significantly higher than men (p=0.001).Scores on PSS-10 showed a significant difference between age groups (p=0.010) in contrast to GA (p=0.515) or PI (p=0.346).The regression model showed that the PI scores were higher among men (B=3.145) than among women (p=0.019).The analysis showed significant effects working during COVID-19 on PI scores (B=3.101; p=0.006).Furthermore, GA was also significantly related to worsening of the COVID-19 pandemic (B=2.73; p=0.004) and was higher among females (B=4.622; p<0.001).
Conclusion:According to the results of the study, gender, age, professional experience and knowledge, and working during a pandemic were important factors for PS and PVD. Additionally, supporting the mental health for HCWs obtaining adequate support and taking precautions are essential.
Causes of Anxiety Among Engineering Students While Making Oral Presentations
in English
Authors: Riaz Mehvish , Rizwan Riaz Muhammad
Published: July 2022

The technical and non-technical presentations made in English by the undergraduate engineering students at the University of Engineering and Technology (UET) Lahore include lab and survey report presentations, project presentations, mid-term or final term presentations in English. The goal of the study was to figure out the engineering students’ reasons behind feeling anxious while giving presentations in English at UET Lahore. For this purpose, 518 undergraduate engineering students from UET, Lahore filled a questionnaire and responded to an open-ended question to determine the causes of anxiety. The data was coded and categorized using in vivo coding system. Findings indicate that the participants mainly experience anxiety due to poor proficiency in English, fear of judgment by the audience, lack of confidence, lack of exposure to speaking English and making presentations in English at school or college level, poor preparation or practice, and insufficient linguistic input. The study has implications for specific lingual assessments, English as a foreign language, and psycholinguistics.
Development of Familial Role Identification Scale for Adolescents with Perceived Parental Disharmony
Authors: Hania Alishba , Subhan Sara , Saleem Sadia , Mahmood Zahid
Published: July 2022

Family plays a pivotal role in the growth and development of the individual and disharmony brings significant distress among family members. To deal with this distress, the family member may seek sources of support to assist in the copying process. An adaptive attitude that leads to this behaviour may result in the adoption of certain roles. In the current study, a standardized assessment measure, that is, The Familial Role Identification Scale for Adolescents (FRIS) was developed to identify these roles. In the development phases of the study (Phase I and Phase II), 40 items were formulated through interviews using open-ended questions and tested for narrative ambiguities. In the main study, FRIS was administered to 390 participants (Boys = 191; Girls = 199) with the age range of 10 to 18 years (M = 14.70; SD = 1.20). Concurrent Validity was examined by using the Role Identification Scale for Children (Samuel et al., 2014). Exploratory Factor Analysis with Varimax Rotation was used to analyze the items and form a factorial structure, that yielded 3 factors indicating different roles adopted by adolescents as Hero, Withdrawal and Mascot with acceptable psychometric properties. Cultural context implications of the results were discussed.
Perceived Social Support as Predictor of Peripartum Mental Illness in Gilgit, Pakistan
Authors: Hussain Sadiq , Saeed Anny
Published: July 2022

This study was conducted to assess perceived social support as predictor of peripartum mental illness in Gilgit region of Pakistan. Peripartum mental illness was defined as antenatal and postnatal depression and anxiety while significant other’s support, family’s support, and friends’ support constituted the concept of perceived social support. Research data were collected from 250 women of ages between 20 and 48 years (M = 28.02 & SD = 5.57) grouped into five categories: first trimester, second trimester, third trimester, four weeks postpartum, and one year postpartum. Participants’ perceived social support, depression, and anxiety were assessed using Multidimensional Perceived Social Support Questionnaire (Akhtar, et al., 2010), Patient Health Questionnaire (Ahmad, et al., 2018), and Generalized Anxiety Disorder Scale (Ahmad, et al., 2018). Kruskal-Wallis test results indicated that there were insignificant differences in all levels of depression and anxiety across five categories. Depression and anxiety were significantly and negatively correlated with significant other’s and family’s support. Women’s occupation was significantly associated with both depression and anxiety; age was significantly correlated only with depression; while living area and monthly income were significantly associated with anxiety. Hierarchical regression analyses revealed that after controlling the effect of demographic variables only family’s support out of the three main variables of social support made significant and independent contribution to women’s depression and anxiety.
Effects of Listening to Quran Recitation and Nature Sounds on Preoperative Anxiety Among Patients Undergoing Surgery
Authors: A. Zulkifli Najhan , I. Z. M. Zain Uzair , A. Hadi Azwanis , N. Ismail Mohd , H. A. Aziz Karimah
Published: July 2022

This study aimed to compare the effectiveness between listening to Quran and nature sounds on preoperative anxiety and physiological parameters. Using systematic random sampling, a randomized controlled trial study was conducted among 81 patients, which comprised of male and female patients allocated into three equal groups, that is, Quran recitation group, nature sounds group, and a control group. Preoperative state anxiety was measured using the State-Trait Anxiety Inventory (Embong, 2018), and physiological parameters were recorded before and after the intervention. After the intervention, the analysis within-subjects showed significant improvement in heart rate, respiratory rate, and state anxiety. However, post-hoc test showed that reduction in the mean state anxiety scores in all groups was the only significant factor. Paired analysis showed that only mean state anxiety level of nature sounds group has a significant reduction in comparison to control group; whereas there was nonsignificant difference in state anxiety of other paired groups when compared between both intervened groups and between Quran group and control group. The result concluded that listening to either the Quran or nature sounds were effective in reducing preoperative anxiety, however head-to-head comparison found no significant difference.
Microstructural Origins of the Corrosion Resistance of a Mg-Y-Nd-Zr Alloy Processed by Powder Bed Fusion – Laser Beam
Authors: Nilsson Åhman Hanna , D’Elia Francesco , Mellin Pelle , Persson Cecilia
Published: July 2022

Magnesium alloys are biocompatible, biodegradable and have the ability to promote bone ingrowth, making them ideal candidate materials for replacing auto- and allografts in future treatments of large bone defects. Powder bed fusion–laser beam (PBF-LB) additive manufacturing of these alloys would further allow for the production of complex structures, optimized for bone grafting. However, the corrosion rates of structures processed by PBF-LB remain too high. An improved understanding of the influence of the microstructure generated during PBF-LB on the corrosion properties is considered key to their future implementation in implants. In this study, the effect of PBF-LB processing and subsequent hot isostatic pressing (HIP) on the microstructure and texture in different sample directions was studied and related to the corrosion behavior of a Mg-Y-Nd-Zr alloy. The results were compared with an extruded Mg-Y-Nd-Zr alloy. A higher amount of secondary phases resulted in a higher rate of localized corrosion for the PBF-LB processed material compared to that for the extruded one. Due to growth of the secondary phases, the corrosion rate was further increased after HIP. Moreover, a strong texture was observed in the PBF-LB material, and it was also enhanced in the HIP material. While this affected the electrochemical activity as measured by potentiodynamic polarization tests, any texture effect appeared to be masked by the contribution of the secondary phases in the longer-term mass change and hydrogen evolution tests. Future work should look further into the influence of individual process parameters on the microstructure and the resulting corrosion behavior of the material, to further clarify its interdependence.
An Intelligent Real-Time Edge Processing Maintenance System for Industrial Manufacturing, Control, and Diagnostic
Authors: Vermesan Ovidiu , Coppola Marcello , Bahr Roy , Bellmann Ronnie Otto , Martinsen Jøran Edell , Kristoffersen Anders , Hjertaker Torgeir , Breiland John , Andersen Karl , Sand Hans Erik , Lindberg David
Published: July 2022

This paper presents an artificial intelligence (AI) based edge processing real-time maintenance system for the purposes of industrial manufacturing control and diagnostics. The system is evaluated in a soybean processing manufacturing facility to identify abnormalities and possible breakdown situations, prevent damage, reduce maintenance costs, and increase production productivity. The system can be used in any other manufacturing or chemical processing facility that make use of motors rotating equipment in different process phases. The system combines condition monitoring, fault detection, and diagnosis using machine learning (ML) and deep learning (DL) algorithms. These algorithms are used with data resulting from the continuous monitoring of relevant production equipment and motor parameters, such as temperature, vibration, sound/noise, and current/voltage. The condition monitoring integrates intelligent Industrial Internet of Things (IIoT) devices with multiple sensors combined with AI-based techniques and edge processing. This is done to identify the parameter modifications and distinctive patterns that occur before a failure and predict forthcoming failure modes before they arise. The data from production equipment/motors is collected wirelessly using different communication protocols - such as Bluetooth low energy (BLE), Long range wide area network (LoRaWAN), and Wi-Fi - and aggregated into an edge computing processing unit via several gateways. The AI-based algorithms are embedded in the processing unit at the edge, allowing the prediction and intelligent control of the production equipment/motor parameters. IIoT devices for environmental sensing, vibration, temperature monitoring, and sound/ultrasound detection are used with embedded signal processing that runs on an ARM Cortex-M4 microcontroller. These devices are connected through either wired or wireless protocols. The system described addresses the components necessary for implementing the predictive maintenance (PdM) strategy in soybean industrial processing manufacturing environments. Additionally, it includes new elements that broaden the possibilities for prescriptive maintenance (PsM) developments to be made. The type of ML or DL techniques and algorithms used in maintenance modeling is dictated by the application and available data. The approach presented combines multiple data sources that improve the accuracy of condition monitoring and prediction. DL methods further increase the accuracy and require interpretable and efficient methods as well as the availability of significant amounts of (labeled) data.
Binary Mixtures of Imidazolium-Based Protic Ionic Liquids. Extended Temperature Range of the Liquid State Keeping High Ionic Conductivities
Authors: Abdurrokhman Iqbaal , Martinelli Anna
Published: July 2022

Binary mixtures based on the two protic ionic liquids 1-ethylimidazolium triflate ([C2HIm][TfO]) and 1-ethylimidazolium bis(trifluoromethanesulfonyl)imide ([C2HIm][TFSI]) have been investigated, with focus on phase behavior, ionic conductivity, and intermolecular interactions as a function of composition (χTFSI indicating the mole fraction of the added compound). It is found that on addition of [C2HIm][TFSI] to [C2HIm][TfO], the melting temperature is first decreased (0 <χ≤ 0.3) and then suppressed (0.3 <χ≤ 0.8) resulting in mixtures with no phase transitions. These mixtures display a wide temperature range of the liquid state and should be interesting for use in devices operating at extreme temperatures. The ionic conductivity does not vary significantly across the composition range analyzed, as evidenced in the comparative Arrhenius plot. The activation energy, Ea, estimated by fitting with the Arrhenius relation in a limited temperature range (between 60 and 140 °C) varies marginally and keeps values between 0.17 and 0.21 eV. These marginal differences can be rationalized by the initially very similar values of the two neat protic ionic liquids. Vibrational spectroscopy, including both Raman and infrared spectroscopies, reveals weakening of the cation–anion interactions for increasing content of [C2HIm][TFSI], which is reflected by the blue shift of the average N-H stretching mode and the red shift of the S-O stretching mode in the TfO anion. These trends correlate with the higher disorder in the mixtures observed by DSC and are evidenced by the decrease and suppression of the melting temperature as the amount of [C2HIm][TFSI] is increased.
Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review
Authors: Alamoudi Mohammed U. , Hosie Suzanne , Shindler Anya E. , Wood Jennifer L. , Franks Ashley E. , Hill-Yardin Elisa L.
Published: July 2022

Many individuals diagnosed with autism spectrum disorder (ASD) experience gastrointestinal (GI) dysfunction and show microbial dysbiosis. Variation in gut microbial populations is associated with increased risk for GI symptoms such as chronic constipation and diarrhoea, which decrease quality of life. Several preclinical models of autism also demonstrate microbial dysbiosis. Given that much pre-clinical research is conducted in mouse models, it is important to understand the similarities and differences between the gut microbiome in humans and these models in the context of autism. We conducted a systematic review of the literature using PubMed, ProQuest and Scopus databases to compare microbiome profiles of patients with autism and transgenic (NL3R451C, Shank3 KO, 15q dup), phenotype-first (BTBR) and environmental (Poly I:C, Maternal Inflammation Activation (MIA), valproate) mouse models of autism. Overall, we report changes in fecal microbial communities relevant to ASD based on both clinical and preclinical studies. Here, we identify an overlapping cluster of genera that are modified in both fecal samples from individuals with ASD and mouse models of autism. Specifically, we describe an increased abundance of Bilophila, Clostridium, Dorea and Lactobacillus and a decrease in Blautia genera in both humans and rodents relevant to this disorder. Studies in both humans and mice highlighted multidirectional changes in abundance (i.e. in some cases increased abundance whereas other reports showed decreases) for several genera including Akkermansia, Bacteroides, Bifidobacterium, Parabacteroides and Prevotella, suggesting that these genera may be susceptible to modification in autism. Identification of these microbial profiles may assist in characterising underlying biological mechanisms involving host-microbe interactions and provide future therapeutic targets for improving gut health in autism.
Development of Immunological Assays Based on Leishmania donovani Antigen for Diagnosis of Canine Visceral Leishmaniasis and Their Multicenter Evaluation in Brazil and Italy
Authors: Ejazi Sarfaraz Ahmad , Saha Samiran , Bhattacharyya Anirban , Das Sonali , Mateus Nathália Lopes Fontoura , da Costa Lima Manoel Sebastião , Neitzke-Abreu Herintha Coeto , de Mendonca Ivete Lopes , Costa Carlos Henrique Nery , de Oliveira Melo Otoni Alves , de Melo Marcia Almeida , Rossi-Bergmann Bartira , Corso Raffaele , Manna Laura , Ali Nahid
Published: July 2022

Canine visceral leishmaniasis (CVL) due to Leishmania infantum infection is a zoonotic disease prevalent in the areas of South America and the Mediterranean. Infected dogs as reservoirs can contribute to disease transmission and can be a scourge to public health. Therefore, early diagnosis of infected dogs may play a pivotal role in circumscribing disease progression. Invasive tissue aspiration and insufficient serological methods impair a single assay for prompt CVL diagnosis. In the present study, we aimed to evaluate the potential of Leishmania donovani isolated membrane protein, LAg, for the diagnosis of CVL through immunological assays. Initially, enzyme-linked immunosorbent assay was done with Brazilian dog sera to evaluate the performance of LAg in diagnosing CVL and found sensitivity and specificity of 92.50% and 95%, respectively. The study further confirmed the diagnostic efficacy of LAg in a dipstick format. The dipstick test of canine sera from three centers in Brazil and one center in Italy collectively showed sensitivity values in the range of 53.33% to 100% in recognizing symptomatic dogs and specificity values between 75% and 100% to rule out healthy dogs. Moreover, a rapid immunochromatographic test was developed and optimized using LAg. This test was able to identify 94.73% of CVL of Brazilian origin with specificity of 97.29%. The current results highlight the reactive potential of the L. donovani antigen, LAg, for L. infantum CVL diagnosis and support our previous findings, which suggest the utility of LAg for the diagnosis of both L. donovani and L. infantum human VL in a variety of endemic regions. LAg as a diagnostic candidate may be employed to identify comprehensive CVL cases in epidemiological areas.
Horizontal and Vertical Transmission of Powassan Virus by the Invasive Asian Longhorned Tick, Haemaphysalis longicornis, Under Laboratory Conditions
Authors: Raney Wilson R. , Herslebs Erik J. , Langohr Ingeborg M. , Stone Madeline C. , Hermance Meghan E.
Published: July 2022

The Asian longhorned tick, Haemaphysalis longicornis, is an ixodid tick native to East Asia that was first detected in North America outside a port of entry in 2017. This invasive species has since been detected in 17 states. As the invasive range of the tick continues to expand, the vector competence of H. longicornis for pathogens native to North America must be assessed. Here, we evaluate the vector competence of H. longicornis for Powassan virus (POWV) under laboratory conditions. POWV is a North American tick-borne flavivirus that is typically transmitted through the bite of Ixodes species ticks. The invasive range of H. longicornis is expected to overlap heavily with the geographic range of Ixodes scapularis and POWV cases, highlighting the potential for this invasive tick species to amplify POWV transmission in natural foci should the native tick vectors and H. longicornis share similar hosts. In these studies, adult female H. longicornis ticks were infected with POWV via anal pore microinjection. Viral RNA and infectious virions were detected in tick tissues via q‐RT‐PCR and focus‐forming assay, respectively. POWV‐injected female ticks were infested on mice, and virus was transmitted to mice during tick feeding, as shown by clinical signs of disease and seroconversion in the tick-exposed mice, as well as the detection of viral RNA in various mouse tissues. A POWV-injected female tick transmitted virus to her larval progeny, indicating that H. longicornis can vertically transmit POWV. These naturally-infected larval ticks were also able to transmit POWV to the mouse on which they fed and to the nymphal stage after molting, further demonstrating that H. longicornis can transmit POWV in the horizontal and transstadial modes. Larval and nymphal ticks were also orally infected with POWV while feeding on viremic mice. Additionally, this study provides the first report of POWV neuropathology based on a natural tick transmission model of POWV. Together, our results suggest that the invasive H. longicornis tick is a competent vector of POWV. These findings underline the growing danger this tick may pose to human health in the United States. Additional scholarship on the tick’s biology, ecology, and pathogen transmission dynamics in nature will be important towards understanding the full public health impact of this invasive species.
Circadian Rhythms Coordinated With Gut Microbiota Partially Account for Individual Differences in Hepatitis B-Related Cirrhosis
Authors: Wang Tongyao , Rong Xingyu , Zhao Chao
Published: July 2022

Cirrhosis is the end stage of chronic liver diseases like chronic hepatitis B. In China, hepatitis B accounts for around 60% of cases of cirrhosis. So far, clinical and laboratory indexes for the early diagnosis of cirrhosis are far from satisfactory. Nevertheless, there haven’t been specific drugs for cirrhosis. Thus, it is quite necessary to uncover more specific factors which play their roles in cirrhosis and figure out the possible therapeutic targets. Among emerging factors taking part in the initiation and progression of cirrhosis, gut microbiota might be a pivot of systemic factors like metabolism and immune and different organs like gut and liver. Discovery of detailed molecular mechanism in gut microbiota and gut liver axis leads to a more promising prospect of developing new drugs intervening in these pathways. Time-based medication regimen has been proofed to be helpful in hormonotherapy, especially in the use of glucocorticoid. Thus, circadian rhythms, though haven’t been strongly linked to hepatitis B and its complications, are still pivotal to various pathophysiological progresses. Gut microbiota as a potential effective factor of circadian rhythms has also received increasing attentions. Here, our work, restricting cirrhosis to the post-hepatitis B one, is aimed to summarize how circadian rhythms and hepatitis B-related cirrhosis can intersect via gut microbiota, and to throw new insights on the development of new and time-based therapies for hepatitis B-related cirrhosis and other cirrhosis.
The Systolic Pulmonary Arterial Pressure Liaises Impaired Cardiac Autonomic Control to Pro-inflammatory Status in Systemic Sclerosis Patients
Authors: Rodrigues Gabriel D. , Vicenzi Marco , Bellocchi Chiara , Beretta Lorenzo , Carandina Angelica , Tobaldini Eleonora , Carugo Stefano , Montano Nicola
Published: July 2022

The current study was undertaken to test the hypothesis that systemic sclerosis (SSc) patients with higher systolic pulmonary arterial pressures (PAPs) present a blunted cardiac autonomic modulation and a pro-inflammatory profile. Thirty-nine SSc patients were enrolled (mean age 57 ± 11 years). ECG and respiration were recorded in the supine (SUP) position and during the active standing (ORT). Heart rate variability (HRV) analysis was performed on samples of 300 beats. The symbolic analysis identified three patterns, 0V%, (sympathetic) and 2UV% and 2LV%, (vagal). The %ΔORT was calculated from the differences between HRV in ORT and SUP, normalized (%) by the HRV values at rest. The PAPs was obtained non-invasively through echocardiography. For the inter-group analysis, participants were allocated in groups with higher (+PAPs ≥ median) and lower PAPs (–PAPs < median) values. At rest, the cardiac sympathetic modulation (represented by 0V%) was positively correlated with PAPs, while parasympathetic modulation (represented by 2LV%) was negatively correlated with PAPs. The dynamic response to ORT (represented by Δ0V% and Δ2LV%), sympathetic and parasympathetic were negatively and positively correlated with PAPs, respectively. The +PAPs group presented a higher inflammatory status and a blunted cardiac autonomic response to ORT (↓Δ0V% and ↑Δ2LV%) compared to the –PAPs group. These findings suggest an interplay among cardiac autonomic control, inflammatory status, and cardiopulmonary mechanics that should be considered for the assessment, monitoring, and treatment of SSc patients.
Prediction of Delivery Within 7 Days After Diagnosis of Early Onset Preeclampsia Using Machine-Learning Models
Authors: Villalaín Cecilia , Herraiz Ignacio , Domínguez-Del Olmo Paula , Angulo Pablo , Ayala José Luis , Galindo Alberto
Published: July 2022

Background

Early onset preeclampsia (eoPE) is a hypertensive disorder of pregnancy with endothelial dysfunction manifested before 34 weeks where expectant management is usually attempted. However, the timing of hospitalization, corticosteroids, and delivery remain a challenge. We aim to develop a prediction model using machine-learning tools for the need for delivery within 7 days of diagnosis (model D) and the risk of developing hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome or abruptio placentae (model HA).

Materials and Methods

A retrospective cohort of singleton pregnancies with eoPE and attempted expectant management between 2014 and 2020. A Mono-objective Genetic Algorithm based on supervised classification models was implemented to develop D and HA models. Maternal basal characteristics and data gathered during eoPE diagnosis: gestational age, blood pressure, platelets, creatinine, transaminases, angiogenesis biomarkers (soluble fms-like tyrosine kinase-1, placental growth factor), and ultrasound data were pooled for analysis. The most relevant variables were selected by bio-inspired algorithms. We developed basal models that solely included demographic characteristics of the patient (D1, HA1), and advanced models adding information available at diagnosis of eoPE (D2, HA2).

Results

We evaluated 215 eoPE cases and 47.9% required delivery within 7 days. The median time-to-delivery was 8 days. Basal models were better predicted by K-nearest-neighbor in D1, which had a diagnostic precision of 0.68 ± 0.09, with 63.6% sensitivity (Sn), 71.4% specificity (Sp), 70% positive predictive value (PPV), and 65.2% negative predictive value (NPV) using 13 variables and HA1 of 0.77 ± 0.09, 60.4% Sn, 80% Sp, 50% PPV, and 87.9% NPV. Models at diagnosis were better developed by support vector machine (SVM) using 18 variables, where D2’s precision improved to 0.79 ± 0.05 with 77.3% Sn, 80.1% Sp, 81.5% PPV, and 76.2% NPV, and HA2 had a precision of 0.79 ± 0.08 with 66.7% Sn, 82.8% Sp, 51.6% PPV, and 90.3% NPV.

Conclusion

At the time of diagnosis of eoPE, SVM with evolutionary feature selection process provides good predictive information of the need for delivery within 7 days and development of HELLP/abruptio placentae, using maternal characteristics and markers that can be obtained routinely. This information could be of value when assessing hospitalization and timing of antenatal corticosteroid administration.