bluuebunny/crossref_metadata_2025 huggingface dataset:
Рroblems of the formation of the language personality of students in the educational process
Authors:   State Institution Luhansk Taras Shevchenko National University, Shpetna Svitlana , Kirichenko Olga ,   State Institution Luhansk Taras Shevchenko National University
Published: January 2023

An important feature of an erudite, comprehensively developed personis a high speech culture. Speech culture as an integral component of the general culture of the individual is one of the most important indicators of education and civility of society. In the article the content and structure of the concept of «linguistic personality» are considered. Authors, relying on scientific research, extrapolate it to the process of formation of the linguistic identity of a school graduate and a university student. By the authors it is emphasized that the development of communication skills requires application of innovative pedagogical methods of learning. It is proved that formed communication skills of students contribute to the successful exchange of knowledge, moral values, attitudes that affect the emotional, volitional and intellectual spheres of personality through which culture is manifested, the level of professional development, upbringing and education. As the research shows, a systematic approach to solving the problem, the formation of students' language personality, involves mastery basic knowledge of the language being studied as a necessary condition full-fledged and effective language activity; the ability to perceive texts and build own language expressions in oral and written forms; the ability to operate with learned and processed texts of various kinds styles and genres; mastering the norms of language culture and language etiquette as a necessary component of professional culture; the ability to adapt to the changing conditions of the language environment and actively influence it environment. As a result of the study, the factors affecting speech culture.
Volubility Characteristic of Toddlers with Cochlear Implants and Its Relation to the Parental Verbal Responsiveness
Authors: Park Heesun , Lee Youjin , Sim Hyun Sub , Lee Youngmee
Published: January 2023

Objectives: The purpose of this study was to investigate the characteristics of volubility of toddlers with cochlear implants (CIs) and their parental verbal responsiveness (PVR) in comparison with toddlers with typical hearing (TH), and to explore the relationships between toddlers’ volubility and PVR in each group. Methods: 12 pairs of toddlers with CIs and their parents and 14 pairs of toddlers with TH and their parents participated in this study. This study utilized the Face to Face/Still Face paradigm to examine for the differences of the toddlers’ volubility and PVR between the two groups. Results: Toddlers with CIs produced less vocalizations than toddlers with TH. However, there was not a significant difference in the vocalization time per minute between the two groups. Parents of toddlers with CIs used less verbal responsiveness, which was positively associated with toddlers’ language development, than parents of toddlers with TH. In the CI group, the frequency of the PVR to toddler’s focus of attention was significantly correlated with the frequency and time of toddlers’ vocalization. Conclusion: Toddlers with CIs showed lower levels of volubility than toddlers with TH during the mother-toddler interaction. Parents of toddlers with CIs responded less frequently to their toddler’s communicative intentions and behaviors than did parents of toddlers with TH. These findings suggest that speech-language pathologists should educate the parents of toddlers with CIs to promote high-quality parental responsiveness.
Bayesian Optimization Based on Student’s T Process for Microstrip Antenna Design
Authors: Li Qing , Meng Fei , Tian Yubo , Wang Xiaoyan
Published: January 2023

Bayesian Optimization (BO) is an efficient global optimization algorithm, which is widely used in the field of engineering design. The probabilistic surrogate model and acquisition function are the two keys to the algorithm. Building an efficient probabilistic surrogate model and designing a collection function with excellent exploring capabilities can improve the performance of BO algorithm, allowing it to find the optimal value of the objective function with fewer iterations. Due to the characteristics of small samples and non-parametric derivation of the Gaussian Process (GP), traditional BO algorithms usually use the GP as a surrogate model. Compared with the GP, the Student’s T Process (STP) retains the excellent properties of GP, and has more flexible posterior variance and stronger robustness. In this paper, STP is used as the surrogate model in BO algorithm, the hyperparameters of the model are optimized by STP, and the estimation strategy function (EST) is improved based on the posterior output of the optimized STP, thus realizing the improved BO algorithm based on the STP. To verify the performance of the proposed algorithm, numerical experiments are designed to compare the performances of the traditional BO algorithm, which includes the lower confidence bound function (LCB) and EST as acquisition function respectively and GP as the surrogate model, and the proposed BO algorithm with STP as the surrogate model and LCB, expected improvement function (EI), expected regret minimization function (ERM) as acquisition function respectively. The results show that the proposed algorithm in this paper performs well when finding the global minimum of multimodal functions. Based on the developed algorithm in this paper, the resonant frequency of printed dipole antenna and E-shaped antenna is modeled and optimized, which further confirms the good design ability and design accuracy of the BO algorithm proposed in this paper.
Eight-port Diagonal Antenna with High Isolation and High Efficiency for 5G Smartphone
Authors: Shao Rui , Wang Junlin , Wang Xin , Wang Yonghao
Published: January 2023

In this letter, an 8x8 multiple-input-multiple-output (MIMO) antenna that operates in the sub-6 GHz (4.7-5.1 GHz) spectrum for 5G MIMO smartphone applications is presented. The design consists of a fully grounded plane with closely orthogonal antenna pairs placed symmetrically on the corners of the smartphone and each antenna element consists of an F-type monopole with dimensions of 18x7.5mm2.  Firstly, the diversity characteristics of orthogonally placed antennas are used to reduce the coupling between antennas. On the other hand, diagonal antennas are connected by a neutral line (NL) to further improve isolation and etched slots on the ground to reduce the coupling between antenna pairs. A good frequency bandwidth (S11 < -10 dB) of 4.7-5.1 GHz has been obtained for the MIMO antenna, and the isolation is lower than 16 dB. In addition, total efficiency (TE) is greater than 77.5%, and the envelope correlation coefficient (ECC) is lower than 0.025. The fabricated antenna prototype is tested and offers good performance.
A Wideband Base Station Antenna Loaded with Bow-Tie-Like Parasitic Elements
Authors: Qi Junwei , Pan Jiakang , Li Yingsong , Huang Guan-Long
Published: January 2023

A ±45° dual-polarization wideband antenna for 5G base station application is proposed using cross dipoles, bow-tie-like parasitic elements and baluns. The antenna is modeled, simulated and optimized to get an optimal size of 115mm × 115mm × 27.8mm. The antenna has a -10dB bandwidth of 2.24GHz-3.75GHz and a fractional bandwidth of 50.4% and its isolation of two orthogonal ports is exceed than 25dB over the operating frequency band. The dual-polarized antenna is fabricated and measured to get a result that it has wide bandwidth, good directional radiation patterns, and high peak gain of 8.1±1.1dBi, making it suitable for 5G base station applications.
Use of research evidence in legislatures: a systematic review
Authors: Ouimet Mathieu , Beaumier Morgane , Cloutier Adrien , Côté Alexandre , Montigny Éric , Gélineau François , Jacob Steve , Ratté Stéphane
Published: January 2023

Background:

Although lawmakers play an essential role in policymaking, there is no systematic review on the use of research evidence in legislatures.

Aims and objectives:

To examine types of research use and factors facilitating and hindering use in legislatures.

Methods:

We conducted a systematic review of studies in legislatures, regardless of geographical region or year of publication. We included empirical studies irrespective of the methodology employed. Thematic synthesis was used to synthesise the type of use and the facilitating and hindering factors to using research evidence in parliaments. We included 21 studies.

Findings:

The most frequently observed type of utilisation was the use for symbolic or tactical purposes. Forms of use specific to legislatures were also identified, such as to prepare questions and debates and to help build consensus. Four categories of factors seen as facilitators or barriers were found: institution and organisation, research characteristics, policy and political context, and individual characteristics. Some factors had already been identified in previous reviews, while others seem to apply exclusively to legislatures.

Discussion and conclusions:

The review identified types of use of research evidence observed in legislatures and developed a new categorisation of factors that may promote or hinder evidence use in this institutional setting. It highlighted a need for more research beyond the US, in unicameral legislatures and in countries with a parliamentary form of government. Content analysis of parliamentary debates in legislative assembly or committee to examine the use of research evidence seems to be underused.
Cavity dumping using a microscopic Fano laser
Authors: Dong Gaoneng , Liang Shih Lun , Sakanas Aurimas , Semenova Elizaveta , Yvind Kresten , Mørk Jesper , Yu Yi
Published: January 2023

A microlaser with low energy consumption and high speed is crucial for on-chip photonic networks. Presently, the modulation of microlasers is based on modulating the gain of the laser, which implies a trade-off between the output peak power and modulation energy. Also, the temporal width of the output pulse is restricted by the carrier relaxation time. These limitations can be overcome by modulating, instead, the loss of the laser by the scheme of cavity dumping, which is ideal for intense and ultrashort pulse generation. However, the miniaturization of cavity-dumped lasers has been a long-standing challenge, and no microscopic cavity-dumped lasers have yet been realized. Here, we demonstrate an ultra-small cavity-dumped microscopic laser based on an optical Fano resonance, which generates optical pulses with peak power more than one order of magnitude higher than the corresponding conventional gain-modulated laser. This demonstration paves the way for realizing microscopic lasers for low-power chip-scale applications.
Tolerance of coralline algae to ocean warming and marine heatwaves
Authors: Krieger Erik C. , Taise Aleluia , Nelson Wendy A. , Grand Johan , Le Ru Eric , Davy Simon K. , Cornwall Christopher E.
Published: January 2023

Ocean warming (OW) and marine heatwaves (MHWs) rapidly transform marine ecosystems, especially when they impact keystone or foundation species. Foundation species such as kelps, fucoids and corals are highly sensitive to heat stress, which threatens the future of temperate seaweed forests and tropical reefs. However, functioning and resilience of these systems also relies on the less conspicuous coralline algae, whose thermal tolerances have gone largely untested. Here, we examined the sensitivity of four temperate coralline algal morphotypes from three different species to four realistic present day and future OW and MHW scenarios (ambient [16°C constant]; ambient+MHW [16°C baseline + a symmetric two-week heatwave with a peak intensity of 18.7°C]; future [18.7°C constant]; future+MHW [18.7°C baseline + a symmetric two-week heatwave with a peak intensity of 21.4°C]). Photo-physiology (e.g., Fv/Fm) and calcification physiology (e.g., proxies for calcifying fluid saturation state ΩCF) were generally unaffected by the treatments, implying a high thermo-tolerance of our study species compared to other important marine foundation species. We ascribe this mainly to their photosynthetic apparatus that, unlike in other photoautotrophs, continued to function under heat stress. Experimental evidence presented here and elsewhere implies that coralline algae are likely to continue to play their crucial ecological roles in a warming ocean. Yet, such predictions are fraught with uncertainty due to the substantial gaps in our knowledge. We attempt to highlight some of these gaps and aim to present potential physiological underpinnings of their thermo-tolerance.
Contextualizing and optimizing novel strategies to improve the latent TB continuum of care: Insights from people living with HIV and health care providers in Brazil
Authors: Salles Isadora , Travassos Paula , Spener-Gomes Renata , Loch Ana Paula , Saraceni Valeria , Lauria Lilian , Cavalcante Solange , Garcia de Oliveira Jamile , Brito de Souza Alexandra , Guimarães Costa Allyson , Sakabe Sumire , Schiavon Nogueira Roberta , Chaisson Lelia H. , Cohn Silvia , Jamal Leda Fatima , Valdez Ramalho Madruga Jose , Cordeiro-Santos Marcelo , Castro Barbara , Portella Ferreira Danielle , Hoffmann Christopher J. , Golub Jonathan E. , Durovni Betina , Kerrigan Deanna
Published: January 2023

Tuberculosis (TB) causes 1 in 3 deaths among people living with HIV (PLHIV). Diagnosing and treating latent tuberculosis infection (LTBI) is critical to reducing TB incidence and mortality. Blood-based screening tests (e.g., QuantiFERON-TB Gold Plus (QFT+)) and shorter-course TB preventive therapy (TPT) regimens such as 3HP (3 months weekly isoniazid-rifapentine) hold significant promise to improve TB outcomes. We qualitatively explored barriers and solutions to optimizing QFT+ and 3HP among PLHIV in three cities in Brazil. We conducted 110 in-depth interviews with PLHIV, health care providers (HCP) and key informants (KI). Content analysis was conducted including the use of case summaries and comparison of themes across populations and contexts. LTBI screening and treatment practices were dependent on HCP’s perceptions of whether they were critical to improving TB outcomes. Many HCP lacked a strong understanding of LTBI and perceived the current TPT regimen as complicated. HCP reported that LTBI screening and treatment were constrained by clinic staffing challenges. While PLHIV generally expressed willingness to consider any test or treatment that doctors recommended, they indicated HCP rarely discussed LTBI and TPT. TB testing and treatment requests were constrained by structural factors including financial and food insecurity, difficulties leaving work for appointments, stigma and family responsibilities. QFT+ and 3HP were viewed by all participants as tools that could significantly improve the LTBI cascade by avoiding complexities of TB skin tests and longer LTBI treatment courses. QFT+ and 3HP were perceived to have challenges, including the potential to increase workload on over-burdened health systems if not implemented alongside improved supply chains, staffing, and training, and follow-up initiatives. Multi-level interventions that increase understanding of the importance of LTBI and TPT among HCP, improve patient-provider communication, and streamline clinic-level operations related to QFT+ and 3HP are needed to optimize their impact among PLHIV and reduce TB mortality.
Understanding headache classification coding within the veterans health administration using ICD-9-CM and ICD-10-CM in fiscal years 2014–2017
Authors: Fodeh Samah Jamal , Fenton Brenda T. , Wang Rixin , Skanderson Melissa , Altalib Hamada , Kuruvilla Deena , Schindler Emmanuelle , Haskell Sally , Brandt Cynthia , Sico Jason J.
Published: January 2023

Objectives

Understand the continuity and changes in headache not-otherwise-specified (NOS), migraine, and post-traumatic headache (PTH) diagnoses after the transition from ICD-9-CM to ICD-10-CM in the Veterans Health Administration (VHA).

Background

Headache is one of the most commonly diagnosed chronic conditions managed within primary and specialty care clinics. The VHA transitioned from ICD-9-CM to ICD-10-CM on October-1-2015. The effect transitioning on coding of specific headache diagnoses is unknown. Accuracy of headache diagnosis is important since different headache types respond to different treatments.

Methods

We mapped headache diagnoses from ICD-9-CM (FY 2014/2015) onto ICD-10-CM (FY 2016/2017) and computed coding proportions two years before/after the transition in VHA. We used queries to determine the change in transition pathways. We report the odds of ICD-10-CM coding associated with ICD-9-CM controlling for provider type, and patient age, sex, and race/ethnicity.

Results

Only 37%, 58% and 34% of patients with ICD-9-CM coding of NOS, migraine, and PTH respectively had an ICD-10-CM headache diagnosis. Of those with an ICD-10-CM diagnosis, 73–79% had a single headache diagnosis. The odds ratios for receiving the same code in both ICD-9-CM and ICD-10-CM after adjustment for ICD-9-CM and ICD-10-CM headache comorbidities and sociodemographic factors were high (range 6–26) and statistically significant. Specifically, 75% of patients with headache NOS had received one headache diagnoses (Adjusted headache NOS-ICD-9-CM OR for headache NOS-ICD-10-CM = 6.1, 95% CI 5.89–6.32. 79% of migraineurs had one headache diagnoses, mostly migraine (Adjusted migraine-ICD-9-CM OR for migraine-ICD-10-CM = 26.43, 95% CI 25.51–27.38). The same held true for PTH (Adjusted PTH-ICD-9-CM OR for PTH-ICD-10-CM = 22.92, 95% CI: 18.97–27.68). These strong associations remained after adjustment for specialist care in ICD-10-CM follow-up period.

Discussion

The majority of people with ICD-9-CM headache diagnoses did not have an ICD-10-CM headache diagnosis. However, a given diagnosis in ICD-9-CM by a primary care provider (PCP) was significantly predictive of its assignment in ICD-10-CM as was seeing either a neurologist or physiatrist (compared to a generalist) for an ICD-10-CM headache diagnosis.

Conclusion

When a veteran had a specific diagnosis in ICD-9-CM, the odds of being coded with the same diagnosis in ICD-10-CM were significantly higher. Specialist visit during the ICD-10-CM period was independently associated with all three ICD-10-CM headaches.
Quantifying knowledge from the perspective of information structurization
Authors: Wang Xinbing , Kang Huquan , Fu Luoyi , Yao Ling , Ding Jiaxin , Wang Jianghao , Gan Xiaoying , Zhou Chenghu , Hopcroft John E.
Published: January 2023

Scientific literature, as the major medium that carries knowledge between scientists, exhibits explosive growth in the last century. Despite the frequent use of many tangible measures, to quantify the influence of literature from different perspectives, it remains unclear how knowledge is embodied and measured among tremendous scientific productivity, as knowledge underlying scientific literature is abstract and difficult to concretize. In this regard, there has laid a vacancy in the theoretical embodiment of knowledge for their evaluation and excavation. Here, for the first time, we quantify the knowledge from the perspective of information structurization and define a new measure of knowledge quantification index (KQI) that leverages the extent of disorder difference caused by hierarchical structure in the citation network to represent knowledge production in the literature. Built upon 214 million articles, published from 1800 to 2021, KQI is demonstrated for mining influential classics and laureates that are omitted by traditional metrics, thanks to in-depth utilization of structure. Due to the additivity of entropy and the interconnectivity of the network, KQI assembles numerous scientific impact metrics into one and gains interpretability and resistance to manipulation. In addition, KQI explores a new perspective regarding knowledge measurement through entropy and structure, utilizing structure rather than semantics to avoid ambiguity and attain applicability.
Spatial inequality and explaining the urban-rural gap in obesity in India: Evidence from 2015–16 population-based survey
Authors: Barua Somdutta
Published: January 2023

Objective

This study assessed the spatial dimension of urban-rural disparity in obesity prevalence and identified the determinants explaining the urban-rural gap in obesity prevalence in India.

Methods

Using cross-sectional survey data from the 2015–16 National Family Health Survey, the prevalence rates of obesity were calculated for aged 15–49 years. Two multiscale geographically weighted regressions were performed separately from rural and urban spaces for Indian districts to examine the spatial relationship of the outcome variable and covariates at different geographical scales. Fairlie decomposition analysis was carried out to explore the contribution of each variable in the urban-rural gap.

Results

The rural-urban obesity prevalence difference has increased in a decade time for India from 13.0 to 14.6. Urban counterparts tended to have more people with excess weight. 15 states had an urban-rural prevalence ratio of 2 or higher. The MGWR model showed that varying covariates operated at different scales, i.e. global, regional and local scales, and determined the spatial heterogeneity of obesity prevalence. The only variable, i.e. age (9.49 per cent), had contributed in reducing the gap. Conversely, the socioeconomic variables, i.e. income (96.39 per cent), education (4.95 per cent), caste (4.78 per cent) and occupation (3.11 per cent), had widened the gap.

Conclusions

Even though this study evidenced the rural-urban gap in obesity prevalence, it indicated the gap’s closing shortly, as it was witnessed in a few states. It is urgent to address the obesity epidemic, especially in urban India, due to its higher prevalence and prevent the further increase of prevalence in rural India, mainly because it shelters nearly 70 per cent of the Indian population.
First sex modification case in equine cloning
Authors: Suvá Mariana , Arnold Victoria Helga , Wiedenmann Elisabet Astrid , Jordan Roberto , Galvagno Emanuel , Martínez Marcela , Vichera Gabriel Damián
Published: January 2023

Somatic cell nuclear transfer (SCNT) is an asexual reproductive technique where cloned offspring contain the same genetic material as the original donor. Although this technique preserves the sex of the original animal, the birth of sex-reversed offspring has been reported in some species. Here, we report for the first time the birth of a female foal generated by SCNT of a male nuclear donor. After a single SCNT procedure, 16 blastocysts were obtained and transferred to eight recipient mares, resulting in the birth of two clones: one male and one female. Both animals had identical genetic profiles, as observed in the analysis of 15-horse microsatellite marker panel, which confirmed they are indeed clones of the same animal. Cytogenetic analysis and fluorescent in situ hybridization using X and Y specific probes revealed a 63,X chromosome set in the female offspring, suggesting a spontaneous Y chromosome loss. The identity of the lost chromosome in the female was further confirmed through PCR by observing the presence of X-linked markers and absence of Y-linked markers. Moreover, cytogenetic and molecular profiles were analyzed in blood and skin samples to detect a possible mosaicism in the female, but results showed identical chromosomal constitutions. Although the cause of the spontaneous chromosome loss remains unknown, the possibility of equine sex reversal by SCNT holds great potential for the preservation of endangered species, development of novel breeding techniques, and sportive purposes.
Effects of feast-famine nutrient regimes on wastewater algal biofuel communities
Authors: Loria Mark H. , Griffin James S. , Wells George F. , Rhoads Kurt R.
Published: January 2023

Microalgae accumulate lipids in response to nutrient deprivation, and these lipids are a biodiesel fuel stock. Algal cultivation with secondary wastewater effluent is one proposed platform for biofuel production, which provides nutrients to algae while further polishing wastewater effluent. Algal bioreactors were tested using a feast-famine feeding regiment in simulated secondary wastewater effluent to evaluate the effects on lipid content and algal community structure. Algal polycultures were inoculated into reactors fed with synthetic secondary wastewater effluent at pH 7.5 and 9 and operated under a feast-famine nutrient (N, P, and BOD) supply regime in sequencing batch reactors. Fatty acid methyl ester contents of the reactors were assessed, which showed a decrease in lipid content after the feast-famine cycling (from 12.2% initially to 5.2% after four cycles at pH 9). This decrease in lipid content was not correlated with an increase in carbohydrate storage within biomass, nor an increase in bacterial biomass abundance relative to algal biomass in the reactors. The eukaryotic microbial communities from reactors operated at pH 9 diverged from reactors operated at pH 7.5 during cycling, with the pH 9 reactors becoming dominated by a single Operational Taxonomic Unit aligning to theScenedesmusgenus. These results suggest that high pH and feast-famine nutrient cycling may select for a less diverse algal community with a lower lipid content within a secondary wastewater polishing scheme.
Associations between chronic conditions and death in hospital among adults (aged 20+ years) during first acute care hospitalizations with a confirmed or suspected COVID-19 diagnosis in Canada
Authors: Zakaria Dianne , Aziz Samina , Bartholomew Sharon , Park Su-Bin , Robitaille Cynthia , Weeks Murray
Published: January 2023

Purpose

We aimed to quantify life course-specific associations between death in hospital and 30 chronic conditions, and comorbidity among them, in adults (aged 20+ years) during their first acute care hospitalization with a confirmed or suspected COVID-19 diagnosis in Canada.

Methods

We identified 35,519 first acute care hospitalizations with a confirmed or suspected COVID-19 diagnosis in the Discharge Abstract Database as of March 31, 2021. For each of five life-course age groups (20–34, 35–49, 50–64, 65–79, and 80+ years), we used multivariable logistic regression to examine associations between death in hospital and 30 chronic conditions, comorbidity, period of admission, and pregnant status, after adjusting for sex and age.

Results

About 20.9% of hospitalized patients with COVID-19 died in hospital. Conditions most strongly associated with in-hospital death varied across the life course. Chronic liver disease, other nervous system disorders, and obesity were statistically significantly associated (α = 0.05) with in-hospital death in the 20–34 to 65–79 year age groups, but the magnitude of the associations decreased as age increased. Stroke (aOR = 5.24, 95% CI: 2.63, 9.83) and other inflammatory rheumatic diseases (aOR = 4.37, 95% CI: 1.64, 10.26) were significantly associated with in-hospital death among 35 to 49 year olds only. Among 50+ year olds, more chronic conditions were significantly associated with in-hospital death, but the magnitude of the associations were generally weaker except for Down syndrome in the 50 to 64 (aOR = 8.49, 95% CI: 4.28, 16.28) and 65 to 79 year age groups (aOR = 5.19, 95% CI: 1.44, 20.91). Associations between comorbidity and death also attenuated with age. Among 20 to 34 year olds, the likelihood of death was 19 times greater (aOR = 18.69, 95% CI: 7.69, 48.24) in patients with three or more conditions compared to patients with none of the conditions, while for 80+ year olds the likelihood of death was two times greater (aOR = 2.04, 95% CI: 1.70, 2.45) for patients with six or more conditions compared to patients with none of the conditions.

Conclusion

Conditions most strongly associated with in-hospital death among hospitalized adults with COVID-19 vary across the life course, and the impact of chronic conditions and comorbidity attenuate with age.
Curcumin’s mechanism of action against ischemic stroke: A network pharmacology and molecular dynamics study
Authors: Wang Yangyang , Zu Guoxiu , Yu Ying , Tang Jiqin , Han Tao , Zhang Chengdong
Published: January 2023

Ischemic stroke (IS) is one of the major global causes of death and disability. Because blood clots block the neural arteries provoking ischemia and hypoxia in the brain tissue, IS results in irreversible neurological damage. Available IS treatments are currently limited. Curcumin has gained attention for many beneficial effects after IS, including neuroprotective and anti-inflammatory; however, its precise mechanism of action should be further explored. With network pharmacology, molecular docking, and molecular dynamics (MD), this study aimed to comprehensively and systematically investigate the potential targets and molecular mechanisms of curcumin on IS. We screened 1096 IS-related genes, 234 potential targets of curcumin, and 97 intersection targets. KEGG and GO enrichment analyses were performed on these intersecting targets. The findings showed that the treatment of IS using curcumin is via influencing 177 potential signaling pathways (AGE-RAGE signaling pathway, p53 signaling pathway, necroptosis, etc.) and numerous biological processes (the regulation of neuronal death, inflammatory response, etc.), and the AGE-RAGE signaling pathway had the largest degree of enrichment, indicating that it may be the core pathway. We also constructed a protein–protein interaction network and a component–target–pathway network using network pharmacology. From these, five key targets were screened: NFKB1, TP53, AKT1, STAT3, and TNF. To predict the binding conformation and intermolecular affinities of the key targets and compounds, molecular docking was used, whose results indicated that curcumin exhibited strong binding activity to the key targets. Moreover, 100 ns MD simulations further confirmed the docking findings and showed that the curcumin–protein complex could be in a stable state. In conclusion, curcumin affects multiple targets and pathways to inhibit various important pathogenic mechanisms of IS, including oxidative stress, neuronal death, and inflammatory responses. This study offers fresh perspectives on the transformation of curcumin to clinical settings and the development of IS therapeutic agents.
E Deus criou o homem para contar histórias
Authors: Diogo João Emanuel
Published: January 2023

Partindo de uma abordagem geral das mitologias clássicas e pré-clássicas, apresentamos neste texto o que se pode considerar como breve introdução ao mito, desenvolvendo quatro funções fundamentais, que permitem uma base de leitura e interpretação: a função escatológica, a função social, a função diária e a função profética-apocalíptica. Mais do que uma separação entre mito e razão, tentaremos abordar como há razões para o mito e como estas se fundam na relação do homem com o uso simbólico da linguagem.
A Epígrafe Latina como Elemento Didático (XXXIX)
Authors: D'Encarnação José
Published: January 2023

Prossegue-se no intuito de mostrar como a análise cuidada de uma epígrafe romana pode fornecer informações válidas do ponto de vista da vivência cultural nessa época. Se um texto escrito se destinava, então, ao público seu contemporâneo, um texto gravado visava o presente e o futuro.Utiliza-se o exemplo de uma epígrafe quase desconhecida, guardada no Museu Nacional Soares dos Reis, no Porto, para mostrar a evidência do que se pretende demonstrar. No caso, porém, deste epitáfio, há três aspectos a salientar: o importante papel da mulher, a ternura familiar e, do ponto de vista cultural, a progressiva aculturação onomástica.
Behavioral responses to baited enclosure method that activates habituation in stray dogs
Authors: Thammacharoen Sumpun , Semsirmboon Sapon , Chit-Opas Visara , Tangcharoensin Phak-Anong , Nilkachatarn Kran , Chaiyabutr Narongsak
Published: January 2023

Background and Aim: The behavioral mechanism of stray dog occurrence is associated with domestication process. This study aimed to investigate the population and demographic relationship of stray dogs from our ecological habitat. We tested whether baited enclosure method could be used as an operant conditioning treatment to activate habituation behavior in stray dogs.

Materials and Methods: The first investigation determined the population and demographic characteristics of stray dogs in the metropolitan city of Bangkok using the mark and recapture procedure. In the second investigation, a large cage equipped with a digital camera was used as the feeding and habituation area. Food was provided at four corners for 2 h. The approach behaviors and eating patterns were recorded during this period for 7 days.

Results: The average number of stray dogs calculated within each cluster was 24 ± 6 dogs. For the natural small habitat, the density of stray dogs was 662 dogs per km2. This indicated that the number of dogs is underestimated using the mark and recapture procedure because of undetected puppies and shifts in the sex ratio in adult dogs. In the second investigation, we demonstrated that food was a potent positive reinforcer for stray dogs. The average onset of cage entry after offering the food was 17 min. The onset of cage entry and the reduction in the first meal duration suggested that the habituation process could be achieved within 1 week.

Conclusion: The results revealed the possibility of using a large cage as a novel enclosure for food offered as the positive reinforcer for TNR program trapping procedures. We suggest that this humane trapping procedure could be used to activate habituation behavior in stray dogs.
Alterações no solo e efeitos na mobilidade iônica resultantes da aplicação de métodos oxidativos para degradação de contaminantes orgânicos em solos impactados por gasolina
Authors: Pugas Marisa Santiago , Hypolito Raphael
Published: January 2023

A gasolina possui em sua composição mais de 200 substâncias potencialmente tóxicas, entre elas, o benzeno, tolueno, etilbenzeno e xilenos (BTEX). Esses agentes poluidores, quando vazados em postos de gasolina, encontram-se, inicialmente, na Zona Não Saturada nas formas adsorvidas e de vapor; em contato com a fase aquosa, se dissolvem parcialmente e atingem as regiões mais profundas, contaminando as águas subterrâneas. Dentre os tratamentos para remediação, destacam-se os processos oxidativos: reagente Fenton, peróxido de hidrogênio, permanganato e persulfato, tratados neste trabalho. A aplicação dessas técnicas de descontaminação promove total degradação de uma grande variedade de substâncias perigosas, resultando em compostos inócuos como gás carbônico e água. Entretanto, na maioria das vezes, sua aplicação leva a efeitos secundários indesejáveis ao meio ambiente como, por exemplo, a liberação de íons metálicos tóxicos. Visando estudar as alterações no solo e na água, foram realizados experimentos laboratoriais utilizando um Latossolo artificialmente impactado por gasolina e tratado com os agentes oxidativos (Fenton, peróxido de hidrogênio, persulfato de sódio e permanganato de potássio). Verificou-se que os tratamentos oxidativos resultam em diminuição do pH, redução dos teores de bases trocáveis e, por se tratar de processos pouco seletivos, ocasionam a degradação da matéria orgânica natural do solo. Essas alterações favorecem a dessorção de íons metálicos que são liberados para a fase aquosa em concentrações que excedem até centenas de vezes o limite estabelecido pela legislação, afetando o meio ambiente e alterando a qualidade das águas, tornando-as inadequadas para o consumo humano.
Potencialidades dos limiares de chuva intensidade-duração na previsão de deslizamentos em Jaraguá do Sul (SC)
Authors: Stabile Rodrigo Augusto , Ferreira Luiz Rafael Alexandre , Marques Ferreira Andrezza , Maturano Egas Harideva , Magalhães de Andrade Márcio Roberto
Published: January 2023

Um dos grandes desafios dos sistemas de monitoramento e alerta de desastres naturais é prever em que momento e sob quais condições os deslizamentos ocorrem. Os limiares intensidade-duração, ao utilizar a duração e a intensidade média dos eventos de chuva para estimar quais deles são capazes de deflagrar deslizamentos, têm potencial prático e têm sido extensivamente aplicados mundialmente na análise de deslizamentos deflagrados pela chuva. Consequentemente, buscando ampliar as possibilidades de previsão de deslizamentos no Brasil e explorar a boa resolução temporal e espacial das informações de chuva dos pluviômetros do Centro Nacional de Monitoramento e Alertas de Desastres Naturais (Cemaden), esta pesquisa teve como objetivo definir limiares de chuva do tipo intensidade-duração para o município de Jaraguá do Sul (SC). Para isso, foram utilizados dez eventos de chuva com registro de deslizamentos, definidos por chuvas com um intervalo de até 12 horas com ausência de precipitação, para os quais foram calculadas a intensidade (I), medida em mm/h, e a duração (D), medida em horas. Para a construção dos limiares os dados de I e D dos eventos de chuva com deslizamentos foram plotados em gráfico log-log e ajustados a partir de uma Função Potência com o mesmo expoente da linha de regressão dos dados. Foi possível elaborar dois limiares de chuva: o Limiar A que abrange quaisquer ocorrências de deslizamento e o Limiar B que delimita os eventos de precipitação capazes de deflagrar dez ou mais deslizamentos. Com taxas de acerto médias de até 29,8% e 62,5%, respectivamente, estimou-se que 3,2% dos eventos de chuva ocorridos entre 2016 e maio/2022 estão acima do Limiar A e que 0,4% superam o Limiar B. Os resultados encorajam a expansão de estudos de limiares intensidade-duração para outros municípios e regiões de maneira a aperfeiçoar o potencial de previsão de desastres causados por deslizamentos no território brasileiro.
The Bauru Basin in São Paulo and its tetrapods
Authors: Langer Max , Delcourt Rafael , C. Montefeltro Felipe , C. G. Silva Júnior Julian , G. Soler Mariana , S. Ferreira Gabriel , V. Ruiz Juan , A. Barcelos Lucas , Onary Silvio , C. A. Marsola Júlio , C. Castro Mariela , M. Cidade Giovanne , Batezelli Alessandro
Published: January 2023

The Bauru Basin bears one of the best sampled tetrapod paleofaunas of Brazil, with about 70% of this diversity collected from its deposits in São Paulo. Its fossils are known since the beginning of the 20th century, coming from all stratigraphic units of the Basin cropping-out in the state, i.e., Santo Anastácio, Araçatuba, Adamantina (alternatively divided into Vale do Rio do Peixe, Presidente Prudente, and São José do Rio Preto formations), and Marília formations. Identified taxa include rare anurans, mammals, and squamates, an important set of testudines, theropods (including birds), and sauropods, in addition to one of the most diverse crocodyliform faunas known worldwide. This congregates more than fifty unique taxonomic entities, including 42 formally described species. Based on biostratigraphic correlations (including tetrapods), on few absolute ages, and other sources of evidence, the Bauru Basin deposits in São Paulo seem to be chronologically restricted to the Late Cretaceous, but further investigation is much needed. Finally, the history of research with such fossils highlights the importance of public funding for research and decentralization of university education for the advancement of science.
Benefícios do silício orgânico como ativo cosmético na prevenção do envelhecimento cutâneo / Benefits of organic silicon as a cosmetic active in the prevention of skin aging
Authors: Cordeiro Beatriz Moreira , Machado Karina Elisa , Weickert Luana Menezes
Published: January 2023

: O envelhecimento é um processo natural, caracterizado por alterações morfológicas, bioquímicas e fisiológicas que ocorrem progressivamente no decorrer do tempo. Existem inúmeras maneiras de tratar e prevenir o envelhecimento cutâneo, entre estas destaca-se o uso cosméticos com silício orgânico. O silício orgânico é o oligoelemento, de natureza ubíqua mais abundante na terra, o corpo humano possui silício orgânico em sua composição, desde a fase fetal, sendo que com o passar do tempo suas concentrações diminuem. Este ativo apresenta diversas funções, dentre as quais pode-se citar sua atividade antioxidante e umectante, estimulante da síntese de colágeno e elastina, além de auxiliar na estruturação dérmica. Nesta perspectiva, através de uma revisão bibliográfica descritiva com abordagem qualitativa, o presente artigo tem como objetivo analisar os benefícios do silício orgânico como ativo cosmético, na prevenção do envelhecimento cutâneo. Os resultados evidenciaram que o silício apresenta diversas funções entre as quais pode-se destacar a síntese de colágeno e elastina, sendo que em conjunto, os resultados encontrados demonstraram que o silício é um ativo cosmético seguro e promissor na prevenção do envelhecimento cutâneo. Abstract: Aging is a natural process, characterized by morphological, biochemical and physiological changes that occur progressively over time. There are countless ways to treat and prevent skin aging, among which we highlight the use of cosmetics with organic silicon. Organic silicon is the most abundant ubiquitous trace element on earth, the human body has organic silicon in its composition since the fetal phase, and over time its concentrations decrease. This active has several functions, among which we can highlight the antioxidant, humectant, stimulating collagen and elastin synthesis, besides helping in dermal structuring. In this perspective, through a descriptive bibliographic review with a qualitative approach, this article aims to analyze the benefits of organic silicon as a cosmetic asset, in preventing skin aging. The results showed that silicon has several functions, among which the synthesis of collagen and elastin can be highlighted, and together, the results found showed that silicon is a safe and promising cosmetic asset in the prevention of skin aging.Keywords: Skin aging. Self-esteem. Cosmetics. Organic Silicon.
A Pessoa com Esclerose Múltipla sob a perspectiva da Logoterapia: Uma Revisão Integrativa da Literatura / The Person with Multiple Sclerosis from the Logotherapy Perspective: An Integrative Literature Review
Authors: Cardoso Jeice Sobrinho , Souza Airle Miranda de , Corrêa Victor Augusto Cavaleiro
Published: January 2023

Resumo: O presente estudo tem o objetivo de revisar artigos científicos que abordam sobre a Esclerose Múltipla na perspectiva da Logoterapia por meio de uma Revisão Integrativa da Literatura. As buscas foram realizadas nas bases: Biblioteca Virtual em Saúde - Brasil (BVS Brasil); Scientific Electronic Library Online (SciElo); Serviço da Biblioteca Nacional de Medicina dos Estados Unidos para acesso gratuito ao Medline (PubMed) e Revista Logos & Existência, vinculada à Associação Brasileira de Logoterapia e Análise Existencial (ABLAE). A revisão aponta como resultados o quanto ainda se pode avançar nos estudos da Esclerose Múltipla na perspectiva da Logoterapia e como a Logoterapia pode ser eficaz para o tratamento de quadros de ansiedade de pessoas com Esclerose Múltipla. Abstract:The present study aims to review scientific articles that address Multiple Sclerosis from the perspective of Logotherapy through an Integrative Literature Review. The searches were carried out in the following databases: Virtual Health Library - Brazil (BVS Brazil); Scientific Electronic Library Online (SciElo); Service of the National Library of Medicine of the United States for free access to Medline (PubMed) and Revista Logos & Existência, linked to the Brazilian Association of Logotherapy and Existential Analysis (ABLAE). The review points out as results how much progress can still be made in Multiple Sclerosis studies from the perspective of Logotherapy and how Logotherapy can be effective for the treatment of anxiety in people with Multiple Sclerosis.Keywords: Multiple Sclerosis; Logotherapy; Psychotherapy
CriançARTE: cartografando processos e (des)construindo sentidos com “pessoas pequenas” / CriançaARTE: Mapping processes and (de)constructing meanings with “small people”
Authors: Neves Rafael Dorneles , Limachi Elysangela Koglin Ulo , Zucolotto Marcele Pereira da Rosa
Published: January 2023

Resumo: O artigo apresenta o relato de uma experiência vivenciada em uma escola, por um grupo de estudantes de graduação em psicologia que, diante de uma proposta de extensão derivada da disciplina curricular, decidiram aproveitar a oportunidade para se lançar no campo e construir a partir dos encontros uma experiência cartográfica, princípio constituinte do rizoma, conceito nascido na botânica e importado por Gilles Deleuze e Félix Guattari para compor sua filosofia da diferença. Propomo-nos a fazer um relato tal como se estivéssemos a escrever em um diário de campo, cartografando os afetos que nos atravessaram, esboçando nossos encontros com o campo, com a equipe e as crianças da escola, alinhando nosso saber-fazer com as ideias de Deleuze e Guattari. Por fim, contamos acerca do andamento da oficina CriançARTE, suscitando reflexões acerca dessa produção coletiva que só foi possível por estarmos em constante atravessamento com um modelo rizomático-cartográfico de fazer pesquisa-intervenção.Palavras-chave: rizoma; cartografia; arte; criança. Abstract: The article presents the report of an experience lived in a school by a group of undergraduate psychology students who, faced with a proposal for an extension derived from the curricular discipline, decided to take advantage of the opportunity to launch themselves in the field and build from from the encounters a cartographic experience, constituting principle of the rhizome, a concept born in botany and imported by Gilles Deleuze and Félix Guattari to compose their philosophy of difference. We propose to make a report as if we were writing in a field diary, mapping the affections that crossed us, outlining our encounters with the field, with the team and the children of the school, aligning our know-how with the ideas by Deleuze and Guattari. Finally, we talk about the progress of the CriançARTE workshop, raising reflections about this collective production that was only possible because we were in constant crossing with a rhizomatic-cartographic model of doing research-intervention.Keywords: rhizome; cartography; art; child.
Ação do Enfermeiro frente aos principais fatores associados a ocorrencia de Sepse na Unidade de Terapia Intensiva / Action of the Nurse in front of the main factors associated with the occurrence of Sepsis in the Intensive Care Unit
Authors: Kaeser Jéssica Oliveira Santos , Dias Graziela Monteiro , Silva Fábio Soares da , Santos José Ribeiro dos
Published: January 2023

Resumo: O objetivo foi identificar através da literatura os principais fatores de ocorrência de sepse na Unidade de Terapia Intensiva (UTII) adulto. Método utilizado revisão integrativa de literatura. Resultados: As infecções que podem levar à sepse mais comumente são de focos pulmonares, abdômen ou trato urinário. Pacientes que fazem uso dos dispositivos como intubação orotraqueal (IOT) sob ventilação pulmonar, cateter de artéria pulmonar, cateter vesical de demora (CVD) potencializam o risco de desencadear uma infecção. Conclusão: Além dos focos de infecções, fatores de risco como: idade superior a 65 anos, maior tempo médio de internação na UTI e sexo masculino, potencializa o risco de desenvolver um quadro de disfunção orgânica ameaçadora à vida.Palavras-chave: Sepse, UTI, Enfermeiro, Fatores de Risco. Abstract: The objective was to identify through the literature the main factors of occurrence of sepsis in the adult Intensive Care Unit (ICU). Results: Infections that can lead to sepsis are most commonly found in the lungs, abdomen or urinary tract. Patients who use devices such as orotracheal intubation (OTI) under pulmonary ventilation, pulmonary artery catheter, indwelling urinary catheter (CVD) increase the risk of triggering an infection. Conclusion: In addition to the outbreaks of infections, risk factors such as age over 65 years, longer average length of stay in the ICU and male gender, increase the risk of developing life-threatening organ dysfunction.Keywords: Sepsis, UCI, Nurse, Risk Factors.