bluuebunny/crossref_metadata_2025 huggingface dataset:
Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
Authors: Tiwari Abhishek , Tiwari Varsha , Sharma Ajay , Marrisetti Arya Lakshmi , Kumar Manish , Rochani Ankit , Kaushik Deepak , Mittal Vineet , Jyothi S. Renuka , Ali Haider , Hussain Md Sadique , Gupta Gaurav
Published: December 2024

Skin carcinoma, which includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, is influenced by various factors such as genetic predisposition, chemical exposures, immune system imbalances, and ultraviolet (UV) radiation. This review delves into the mechanisms behind the development of these cancers, exploring the therapeutic potential of microbial, plant derived compounds and nanoparticles in advancing skin cancer treatments. Special attention is given to the cytotoxic effects of anti-neoplastic agents from microbial sources on different cancer cell lines, particularly melanoma. Additionally, the review highlights the role of phytochemicals – such as quercetin, resveratrol, and curcumin alongside vitamins, terpenoids, and sulforaphane, in management of skin cancers through mechanisms like apoptosis induction and cell cycle regulation. Recent advancements in nanotechnology-based drug delivery systems, including NP and microemulsion formulations, are also discussed for their enhanced ability to specifically target cancer cells. The diverse roles of NPs in skin cancer therapy, especially in terms of targeted drug delivery and immune modulation, are reviewed. These innovative NPs formulations have showed improved skin penetration and tumor-specific delivery, reduced systemic toxicity and enhanced therapeutic effectiveness.
The Turn to Interiority in the Early Modern Period
Authors: Faesen Rob
Published: December 2024

The spirituality of the Early Modern Period – and especially in the Devotio Moderna and Ignatius of Loyola – is often associated with a turn to “interiority.” The question is then: to what does one turn? The Pro Theologia Mystica Clavis (1640) of Maximilianus Sandaeus offers a useful hermeneutical principle. In his explanations of the nature of interiority, he emphasized that it is fundamentally a “turning to the Other,” to God, which strips the human person of its own images and forms. This “turn inwards” is a response to the initiative of God, who is present in the “ground” of the soul, and is thus more present to the human person than the human person is to himself. This “ground” is not the “self” as such, but the fundamental relationality. Interiority concerns the encounter and the deepening relationship between the human person and God, and thus indirectly the human person as a “person” and not the “self” of the individual. This perspective has older roots, as it can be seen, e.g., in the discussion between Peter Abelard and William of Saint-Thierry in the twelfth century.
The Perils of Freethinking according to George Berkeley (1685–1753)
Authors: Luis-López Alberto
Published: December 2024

George Berkeley’s (1685–1753) condemnation of freethinking arose from the social, political, and, above all, moral repercussions that he believed this heterogeneous group was bringing about in British society. In the first part of this paper, I set out the challenges posed by the freethinking movement, drawing extensively on Berkeley’s Alciphron. In the second part, I address both the reasons behind his aversion to freethinking and his response, which involved advocating for the union of Church and state and while rejecting secular governance. This analysis relies primarily on lesser-known works from Berkeley’s socio-political writings. The paper argues that Berkeley’s opposition to freethinkers was driven by his concern for the public good and his belief that the Christian religion, particularly in its Anglican tradition, was the most effective means to achieve it.
Controversy in the Classroom: Jacobus Janssonius (1547–1625) versus Leonardus Lessius on Grace, Free Will and Predestination
Authors: Van den Eede Linde
Published: December 2024

The present article analyses Jacobus Janssonius’ (1547–1625) theology of grace and free will against the backdrop of the enduring polemics of the Louvain Faculty of Theology with the Jesuit order on grace, free will and predestination. As one of the protagonists in the Faculty’s conflict with Leonardus Lessius, Janssonius was tasked with teaching a lectio publica intended to counter the Jesuits’ optimistic evaluation of human free will. In this ad hoc course, Janssonius discussed the reconciliation of efficacious grace with human free will, a topic he would return to as Regius professor of Sacred Scripture (1598–1616). On the basis of previously unstudied manuscripts – fragments from his 1587 lectio publica and student notes taken during his tenure as Regius professor – I will challenge the traditional portrayal of Janssonius as a watered-down dupe of Michael Baius’ radicalized anti-Pelagian theology. Rather than slavishly transmitting Baianism to his students, Jacobus Janssonius actively incorporated Baius’ pessimistic theological anthropology into a scholastic framework, allowing him to teach an anti-Pelagian theology of grace that respected the boundaries of Gregory XIII’s definitive condemnation of the Roman interpretation of Baianism with Provisionis nostrae (1580).
Atraumatic forceps-guided insertion of the cervical pessary: a new technique to prevent preterm birth in women with asymptomatic cervical shortening
Authors: Dereli Murat Levent , Obut Mehmet , Özkan Sadullah , Sucu Sadun , Fıratlıgil Fahri Burçin , Kurt Dilara , Kurt Ahmet , Sarsmaz Kemal , Tolunay Harun Egemen , Çağlar Ali Turhan , Üstün Yaprak Engin
Published: December 2024

Objectives

As previous studies on the use of a cervical pessary to prevent preterm birth (PTB) have produced conflicting results, we aimed to investigate the feasibility, acceptability and safety of a new technique for inserting a cervical pessary and compare it with the traditional technique in patients at high risk of PTB.

Methods

Women at high risk of PTB treated with a cervical pessary between January 2018 and January 2021 were retrospectively evaluated. After applying exclusion criteria, a total of 68 eligible patients were identified and retrospectively analyzed. The primary outcome was spontaneous PTB before 34 weeks’ gestation (WG).

Results

Of 68 participants, 39 were treated with the traditional method (group 1) and 29 with the new insertion technique (group 2). The rate of spontaneous PTB before 34 WG was significantly lower in group 2 (p=0.020). Birthweight, APGAR scores and satisfaction with the method were significantly higher, while PTB before 37 WG was significantly lower in group 2 (p=0.043, 0.010, 0.009, 0.042 and 0.014, respectively). There were no significant differences in the rates of perinatal death (12.8 vs. 3.4 % in groups 1 and 2, respectively; p=0.229). The concomitant use of vaginal progesterone was required more frequently in group 1. According to the binary regression analysis, the new insertion technique resulted in a 5.42 and 3.97-fold protection against PTB before 34 and 37 WG.

Conclusions

Our preliminary results show that our new technique of pessary insertion is more effective than the traditional method in preventing PTB due to cervical shortening.
Investigation of weak solutions for p(z)-Kirchhoff equations by Young measure techniques
Authors: Allalou Mouad , Raji Abderrahmane
Published: December 2024

The present article deals with the existence of weak solutions to a class of

p

(

z

)

p\left(z)

-Kirchhoff-type problems. To address these problems, we employ a variational approach in conjunction with the theory of variable exponent Sobolev spaces, while imposing suitable assumptions on the source term. Furthermore, we utilize the theory of Young measures.
Enhanced mechanical properties of Sr-modified Al–Mg–Si alloy by thermo-mechanical treatment
Authors: Karakoca Alper , Yılmaz Serdar Osman
Published: December 2024

In this study, the effect of thermomechanical treatments applied to strontium-modified A360 alloy on the microstructure and mechanical properties of the alloy was investigated. Optical microscopy, XRD, and SEM were employed to examine the microstructural properties, while tensile and hardness tests were conducted on the samples to evaluate the mechanical properties. It was observed that the strength values increased as the deformation amount increased, and subsequently, optimum conditions (tensile strength and ductility) were determined after the subsequent aging treatment. Following cold deformation, dendritic structure shifted towards the direction of deformation along with the eutectic silicon structure. After aging, it was found that the dendritic structure transformed into equiaxed grains at certain temperature. The highest tensile strength of 383 MPa was achieved in the sample with a deformation amount of 70 %. In this case, the ductility value was 2.85 %. Subsequently, the optimum conditions after aging were determined as 160 °C & 4 h, resulting in a tensile strength of 341 MPa and ductility of 3.62 %.
Analysis of farm performance to realize the sustainability of organic cabbage vegetable farming in Getasan Semarang, Indonesia
Authors: Winahyu Wulansari , Rahayu Endang Siti , Darwanto Dwidjono Hadi , Harisudin Mohamad
Published: December 2024

Increasing farmers’ income is possible through high-value markets. Employment, access to financing, and technical support have favorable effects and a rise in income. This research seeks to establish the sustainability of organic cabbage farming through economic performance analysis. Quantitative research methods were conducted in this research. Descriptive quantitative analysis was performed with PLS-SEM software. The research data comprise primary data and secondary data. Of the 11 pathway coefficients in this study, only 9 were significant. The protection variable was positively related to the production optimization construct but did not significantly affect financial performance. The variable “healthy and safe” was positively associated with significant constructs of “financial performance” and “production optimization.” The variable “capacity development” was positively related to the constructs of “financial performance” and “production optimization.” The “technical” variable was significantly positively associated with the construct of “financial performance” but did not significantly affect the construct of “optimization of production.” The variable “production optimization” is positively related to the construct of “financial performance” and the construct of “farm performance” of farmers. Agricultural extension and training must be carried out to improve farmers’ technical knowledge. Government subsidies to support organic farming are also needed to ensure the sustainability of organic cabbage farming in the Semarang district.
A missing paradigm: deciphering endocrine innovations among diverging regulations of alleles, paralogous genes and orthologous genes
Authors: Lareyre Jean-Jacques , Monget Philippe
Published: December 2024

In endocrinology, there are many similarities in the regulation of gene expression between alleles, paralogous genes or orthologous genes, at the genetic or epigenetic level. However, there are also major differences in the spatial and temporal expression patterns of these genes, in particular between species. In few cases, it has been shown in vitro and/or in vivo that regulatory differences are mainly due to subtle differences (from one bp to less than 12 bp) in the nucleotide sequence of transcription factor-binding sites localized in the vicinity of the proximal promoter. In this short review, we propose to cite some of them, without claiming to be exhaustive. We also briefly review new methodologies that allow for more global studies of comparisons of expression regulations at the transcriptional level. We also discuss whether such studies could have given rise to any paradigm.
The Systems Polyethylene and Polypropylene – CNTs Nanofillers: Quantum-chemical Modeling and Experimental Characteristics
Authors: Sementsov Yu.I. , Tang Hao , Wang Dongxing , Demianenko E.M. , Terets M.I. , Ivanenko K.O. , Ignatenko O.M. , Makhno S.M. , Sigareva N.V. , Zhuravskyi S.V. , Hrebelna Yu.V. , Cherniuk О.А. , Kartel M.T.
Published: December 2024

The purpose of this work was to investigate the interaction of graphene-like nanoclusters with fragments of polymers of the same nature, but of a slightly different structure, for example, polyethylene (PE) and polypropylene (PP), experimentally and using quantum chemistry methods. It is experimentally shown that the reinforcement of PE and PP with carbon nanotubes (CNTs) by mixing in the melt, previously distributed from a stable aqueous dispersion on the surface of the polymer powder, leads to a change in structural, mechanical and thermodynamic characteristics.The degree of crystallinity changes, and the coherent scattering domain (CSD) size, the fracture stress increases, the fracture deformation, thermodynamic characteristics change, and such changes in characteristics for the PP-СNTs system prevail in comparison with the PE-CNTs system.
The interaction energy of graphene-like fragments with PE and PP oligomers was calculated. It was established that the energy of interaction of a graphene-like nanocluster with a PP oligomer is greater, compared to PE, which is consistent with experimental data on the melting temperatures of pure polymers and polymer composites with nanotubes. The polymer with the surface of the nanocarbon fragment forms an intermolecular complex that is not covalently bound but is held by intermolecular dispersion forces.
Clinical Profiles of Obstructive Hydrocephalus in Patient with Von Hippel–Lindau
Authors:   College of Medicine, Umm Al-Qura University, Makkah Saudi Arabia, Naqeeb Mohammed R. , Abdulmannan Dina M. ,   College of Medicine, Umm Al-Qura University, Makkah Saudi Arabia
Published: December 2024

Von-Hippel-Lindau (VHL) is an autosomal dominant disease that affects multiple systems that may result in benign and malignant multisystem tumors. The estimated incidence of VHL is 1 in 36,000 births. Disease incidence ranges from 10 to 40 years, with an average of 26 years, and it impacts diverse ethnic groups. VHL results from mutations in the germ line that have been mapped to chromosome 3P25. Currently, this is the only gene known to cause the syndrome. This study presented a case of obstructive hydrocephalus in a patient with VHL. A 19-year-old female was referred to the Eye Clinic for a diagnosis of papilledema. She began to experience vagal abdominal discomfort for no apparent reason. Per exam, the patient had 20/20 OD and 20/400 OS, with an intraocular pressure of 14 OU. The patient's MRI revealed a posterior fossa cranial cystic brain lesion that was obstructing the fourth ventricle and causing obstructive hydrocephalus. Early detection, management, and focal laser treatment of capillary hemangiomas in the retina's periphery led to favorable visual outcomes. Even after vitreoretinal surgery, the tumors may cause exudative retinal detachment and have an inferior visual prognosis if left untreated.
WAR AND PHENOMENOLOGICAL NARRATIVES IN CONTEMPORARY PHILOSOPHICAL-ANTHROPOLOGICAL RESEARCH
Authors: KOVADLO Galyna
Published: December 2024

The author draws attention to the fact that the new millennium has not lived up to the high expectations that the ideological project of «tolerant universalism» and «multicultural liberalism», with its focus on consensus, solidarity, respect for the Other, and emphasis on universal liberal values, could become the ideology of global progress in the 21st century. Instead, misunderstandings, wars, conflicts, and violence have not disappeared from the world stage. On the contrary, there is an observable «budding» of new and new conflicts and wars. Conflict, like evil in general, has deep roots in both historical and psychological experience, as well as in the very ontology of humanity. Therefore, the issue is not about eliminating conflict but about qualitatively changing the direction of conscious human efforts – whether individual, collective, or socially organized. The author argues that, if restraint and tolerance are not cultivated, mutual destruction remains the alternative.

We enter the modern world (which is not unified, but globalized) through the intersubjective space, through dialogical truths, and so on. This requires the establishment of new forms of worldview, new approaches to examining phenomena in nature, society, and the human being. Clearly, today there is a preference for research ideas and principles related to the synergistic approach, self-organization, self-creation, and self-reproduction, both at the level of the macrocosm and the microcosm. Philosophically, these ideas resonate with existentialist and phenomenological narratives and philosophies. The author currently points to the presence of such approaches in the thought of domestic philosophers.
ON THE ACHIEVABLE UPPER LIMIT OF THE ELEVATION ANGLES OF EFFECTIVE DIRECTION FINDING OF TARGETS OVER THE SEA BY THE ROOT-MUSIC METHOD PROVIDED WITH ADEQUATE A PRIORI PARAMETERS
Authors:   O.Ya. Usikov Institute for Radiophysics and Electronics of the NAS of Ukraine, Logvinov Yu , Pedenko Yu. ,   O.Ya. Usikov Institute for Radiophysics and Electronics of the NAS of Ukraine, Reznichenko N. ,   O.Ya. Usikov Institute for Radiophysics and Electronics of the NAS of Ukraine
Published: December 2024

Subject and Purpose. The paper investigates the accuracy of measurements of the elevation angles of targets located near the sur- face of a disturbed sea in the area from the upper limit of their extremely small values to the free space zone. The main part of the study concerns measurements using the root-MUSIC method based on the analysis of the eigenvalues of the autocorrelation matrix of signals received from the target. Under the same conditions, the accuracy of measurements using the amplitude sum-difference (monopulse) method was obtained. The purpose of the work was to determine the upper limit of the location angles up to which the accuracy of the root-MUSIC method exceeds the accuracy of the monopulse method measurements, and thereby determine the area of its effective use.
Methods and Methodology. The study was conducted using computer modeling of the measurement of elevation angles by two types of radio direction finders. The first one used the root-MUSIC measurement method, and the second one used the monopulse method. Both operated at a wave of 3.2 cm and had the same receiving antenna aperture of 2.5 m. The modeling was performed for sea waves from calm to heavy. In addition to interference from the sea, interference caused by internal noise of the direction finders’ receiving channels was taken into account. The modeling calculated the distance dependencies of the measurement errors of the tar- get’s position angles moving at a constant height of 20 m at a distance from 2 to 0.5 km. This ensured the overlap of the position angles in the range of 0.57...2.28 of the width of the sum directional pattern of the monopulse direction finder.
Results. Under the same sea waves and using equal apertures of the receiving antennas, the values of the errors in measuring the target elevation angles by both methods were obtained. Recommendations for choice the a priori parameters of the root-MUSIC method have been developed, which ensure high measurement accuracy in different interference conditions.
Conclusions. It was found that the root-MUSIC method has a higher accuracy of measuring the elevation angles of low-altitude targets over the sea compared to the widely used monopulse method up to position angles equal to twice the width of the sum direc- tional pattern of the monopulse direction finder antenna
Divergences in the Effective Loop Interaction of the Chern–Simons Bosons with Leptons. The Unitary Gauge Case
Authors: Borysenkova Yu. , Gorkavenko V. , Hrynchak I. , Khasai O. , Tsarenkova M.
Published: December 2024

We will consider the extension of the Standard Model (SM) with Chern–Simons type interaction. This extension has a new vector massive boson (Chern–Simons bosons). There is no direct interaction between the Chern–Simons bosons and fermions of the SM. Using only threeparticle dimension-4 interaction of the Chern–Simons bosons with vector bosons of the SM, we consider effective loop interaction of a new vector boson with leptons. We consider the renormalizability of this loop interaction and conclude that, for the computation of loop diagrams in the unitary gauge, we can not eliminate the divergences in the effective interaction of the Chern–Simons bosons with leptons.
Desalination of Seawater. Osmotic Process for “Blue Energy” and Estimation for Desalination
Authors: Ignatov I. , Gluhchev G. , Ignatov A.I.
Published: December 2024

Seawater, a vast resource, holds fresh water that is increasingly crucial in industrially developed countries. The demand for freshwater for domestic use, agriculture, and industry in these nations far surpasses the available supplies, leading to freshwater scarcity. Your invaluable work in water resource management and environmental science, which is pivotal in addressing this issue, is greatly appreciated. This issue is not limited to specific countries in places like Israel and Kuwait, where the level of precipitation is very low, and freshwater reserves do not meet the increasing needs due to the modernization of the economy and population growth. This global relevance underscores the importance of desalination technologies as a potential solution. As we explore the potential of desalination technologies, we are presented with a promising solution to water scarcity- the vast seas and oceans as alternative water sources. This potential is particularly significant in your field of research and expertise, underscoring the relevance of this paper to your work. The countries with the cleanest drinking water usually have large freshwater reserves in lakes, rivers, underground waters, and glaciers, providing a reassuring buffer against water scarcity. Brazil, for instance, benefits from abundant freshwater from the Amazon River and its extensive basin system. Canada boasts numerous lakes and river systems. The United States include large freshwater reserves in the Great Lakes, numerous rivers, and groundwater. Colombia has large freshwater resources, primarily due to numerous rivers and groundwater. Chile is rich in glacier water, further enhancing its water security. This diverse range of water resources underscores the need for desalination technologies to supplement these sources. In Europe, the Scandinavian countries Norway and Sweden have natural resources for clean drinking water from mountain rivers and lakes. Denmark is flat, but like the other Scandinavian countries, it maintains strict environmental policies and a high-quality water supply network. Germany has a well-developed water resource management system that ensures high-quality drinking water. German drinking water typically comes from underground sources, which are considered very clean, as well as from rivers and dams. There are many glacier sources and rivers in the Alpine countries of Austria, Switzerland, and Italy. Ukraine and Romania have large amounts of drinking water from the Carpathians. Bulgaria is rich in rivers and dams. It has 141 mountain peaks with heights of over 2000 m. Some countries have extensive natural resources that help them to provide the necessary drinking water for their citizens, although distribution and accessibility may depend on regional and economic conditions. The following countries have desalination technologies for clean drinking water from seawater – Saudi Arabia, United Arab Emirates, Israel, Singapore, Australia, Spain, and California (USA).
Нетепловий вплив міліметрового випромінювання на флуоресценцію водного розчину барвника родамін 6G
Authors: Yakunov A.V. , Ilchuk D.T.
Published: December 2024

За допомогою флуоресцентної спектроскопiї дослiджено вплив мiлiметрового випромiнювання на воднi розчини органiчного барвника родамiн 6G. Шляхом оптимiзацiї концентрацiї барвника вдалося мiнiмiзувати тепловi ефекти I видiлити внесок нетеплових механiзмiв. Отриманi результати свiдчать про те, що мiлiметрове випромiнювання iндукує структурнi змiни у водному середовищi, що, своєю чергою, призводить до змiни флуоресцентних властивостей барвника.
Causas de la cesación de pagos de la deuda soberana de Venezuela.
Authors: Pérez F. Hermes A. , Mac-Quhae Rafael
Published: December 2024

En Venezuela se dieron varios fenómenos que suelen preceder la cesación de pagos soberanos según la literatura. Entre ellos, se pueden contar la volatilidad del crecimiento económico, el desplome de la actividad y la desalineación del tipo de cambio real —desequilibrio que generó la apreciación del bolívar debido a la paridad fija establecida—. En este artículo, se valida que la debilidad institucional parece ser un determinante del impago de la deuda, situación que se dio después del mayor auge de precios del petróleo del que se tenga registros. El país entra a ser definido como deudor serial debido al incumplimiento periódico de sus obligaciones.
Características epidemiológicas de la tuberculosis en Colombia
Authors: Cruz-Martínez Oscar Andrés , Trujillo-Trujillo Julian
Published: December 2024

Introducción. La tuberculosis (TB) representa un grave problema de salud pública mundial, regional y nacional, toda vez que los datos epidemiológicos indican aún una alta carga de morbimortalidad con graves impactos sociales, económicos y en salud.
Objetivo. Describir las características epidemiológicas de la TB en Colombia.
Materiales y métodos. Estudio descriptivo realizado con los datos oficiales del Programa Nacional de Control de la Tuberculosis de Colombia. Se realizó una caracterización de los casos de TB reportados en el país entre 2019 y 2022. Respecto a los resultados del tratamiento, dada la duración del mismo, para TB sensible se analizaron de 2017 a 2021 y para TB farmacorresistente, de 2017 a 2020. Las tasas de incidencia y mortalidad por TB se calcularon usando los datos históricos registrados en el Programa Nacional de Control de la Tuberculosis entre 2002 y 2022.
Resultados. Entre 2002 y 2015 se observó una tendencia estable en la tasa de incidencia de TB (23-26.4 casos por cada 100 000 habitantes); entre 2016 y 2019 esta tasa sufrió un ligero aumento (25.0 a 27.3 casos), pero en 2020 y 2021, dada la reducción en la detección de casos producto de la pandemia por COVID-19, disminuyó (22.0 y 25.9 casos), aunque en 2022 se observó un aumento importante (31.6 casos por cada 100 000 habitantes), año en el que la tasa de mortalidad fue de 2.4 casos por cada 100 000 habitantes. La proporción de casos en menores de 15 años aumentó entre 2019 y 2022 (2.71% vs. 3.30%). Entre 2017 y 2021 el tratamiento exitoso de casos nuevos y recaídas osciló entre 60.97% y 75.0%.
Conclusiones. El comportamiento de la incidencia y la mortalidad por TB en Colombia muestra una tendencia al aumento.
Morphometric variations in the reef crab Plagusia depressa (Decapoda: Plagusiidae) in the Western tropical Atlantic
Authors: Costa Anne Karolline , Albuquerque Lira Simone Maria , Nunes Silva Lucas , Schwamborn Ralf
Published: December 2024

Introduction: The reef crab Plagusia depressa is widely distributed in tropical oceans. In the Atlantic Ocean, this species is distributed in geographically distant regions with different environmental pressures, which may lead to morphological divergence. Objectives: To explore morphometric differences in Plagusia depressa populations between coastal reefs and an oceanic island in the Western tropical Atlantic. Also, to examine the potential link between the species' phenotypic plasticity and environmental and geographic factors. Methods: A total of 194 crabs were sampled from four Brazilian coastal and oceanic sites (Suape: n= 52, Tamandaré: n= 53, Barra Grande: n= 44, and Fernando de Noronha Archipelago: n= 45) from 2020 to 2022, under distinct anthropogenic and environmental influences. Linear and geometric morphometric analysis employed seven linear measurements and specific landmarks on the carapace, abdomen, and right chelae to pinpoint significant morphometric differences among these areas. Results: The westernmost coastal population exhibited striking differences from the other regions. Male crabs in this population had a pronounced carapace rostrum, while females showed a narrower abdomen, longer telson, and chelae thinning and elongation. It is possible that the pronounced isolation in this area, along with patterns of changes in ocean currents, may influence our results. Female crab carapaces from the island area showed lateral enlargement and pronounced rostrum depressions. Furthermore, being farther from the mainland, this site has oceanic island environmental features, affecting the population through desiccation and air exposure. For male crabs, different right chelae shape across areas showed an impact of food capture and interaction with other organisms on their phenotypic plasticity. Conclusion: Environmental factors such as tidal exposure and habitat composition might affect the phenotypic plasticity of tidal crabs. Moreover, a biogeographical barrier in Northeastern Brazil, which was hitherto given little consideration, holds important implications for the biogeography of the Western tropical Atlantic.
A new type of nest in the genus Quindina (Opiliones: Nomoclastidae) with hypotheses about its origin and a new species for Colombia
Authors: Lancheros Héctor , Arias Cuellar Daniel , Rocha Ricardo Pinto da
Published: December 2024

Introduction: Parental care is a phenomenon that has been recorded for several clades of the order Opiliones, but nest building has only been reported in the Neotropical genus Quindina Roewer, 1914 (Nomoclastidae). Objective: To describe a new type of nest used in parental care by a new species of Quindina and determine its placement in the phylogenetic tree of the genus, to propose hypotheses about the origin of the two types of nests reported so far. Methods: Specimens and nests were collected in La Calera, Cundinamarca, Colombia. Observations of parental care were made both in the field and in terrariums. A new species was described based on somatic characters and penis structure. A phylogenetic analysis was carried out, consensus methods with equal weights, implicit weighting, and successive weighting were used. Results: We describe a new case of parental care with a new type of disc-shaped nest, which we call "pendular disc nest". The nest is built by males of Quindina pendula sp. nov.; this species can be recognized externally by the absence of white spots, the presence of a mushroom-shaped set of patches in the middle part of the prosoma, and the presence of a dark yellow background around most of the tubercles. Results of the phylogenetic analysis showed Q. pendula sp. nov. is sister to all Quindina species except Quindina marginata. Based on the tree, obtained by successive weighting, seven phylogenetic hypotheses, related to the possible origin of the two types of nests recorded in the genus Quindina, were proposed. Conclusions: This study presents a new case of egg guarding and the building of nests in arthropods, which is not very common in nature.
Prismatic bottles from the auxiliary fort and vicus of Intercisa
Authors: Dévai Kata
Published: December 2024

This paper presents the glass prismatic bottles and fragments brought to light in the Roman settlement of Intercisa (today Dunaújváros, Hungary). Bottles occur in a low number among the finds of the vicus and the castellum of Intercisa. Bottles and containers account for around 15% of all vessel fragments, while prismatic bottles have a lower share, around 4%. Almost all identifiable fragments are square bottles, with a single rectangular one amongst them. Their designs vary; most feature geometric motifs, while plant motifs and inscriptions are less frequent. Most fragments presented below are yet unpublished.
Production of Glue (Adhesives) and Quality Evaluation from Catfish Bones.
Authors:   Dept. of Industrial chem., Faculty of Physical Sciences, Joseph Sarwuan Tarka University P.M.B 2373, Makurdi, Nigeria., Gav B.L. , Nanev J.D. , Surma N. ,   Dept. of Industrial chem., Faculty of Physical Sciences, Joseph Sarwuan Tarka University P.M.B 2373, Makurdi, Nigeria., Kutshak P.I. ,   Dept. of Industrial chem., Faculty of Physical Sciences, Joseph Sarwuan Tarka University P.M.B 2373, Makurdi, Nigeria., Owoicho F.O. ,   Dept. of Industrial chem., Faculty of Physical Sciences, Joseph Sarwuan Tarka University P.M.B 2373, Makurdi, Nigeria.
Published: December 2024

The study was carried out on the production of glue from catfish bones obtained from wurukum market, in makurdi metropolis, benue state, Nigeria. The catfish was bought from wurukum market Makurdi, the catfish was process, the bones was reduced to smaller size with aid of a hammer and were analyzed for quality indicators for glue production from catfish bones using standard method. The results of quality indicator for moisture content had the maximum deviation of (1.115) while the pH had the minimum of (-0.090), density had the maximum deviation of (0.431), viscosity had the minimum indicator of (-20.90), and the ash content quality indicator deviation was (0.560). Between the value of the quality indicators for standard glue compared with values obtained from the produced glue. The produced glue was more acidic than the standard glue, more dense, lower viscosity (less result to flow), contain more water and had more ash than the standard glue. The result of the effects of different quantity of water content on quality indicator of produced glue from catfish bones, the mean (x) values of effect of different quantity of water content on moisture content of quality indicator of produced glue from catfish bones had the mean (x) value of (20.08) while the pH had the mean (x) value of (5.92), density had the mean (x) value of (2.174), viscosity had the mean (x) value of (51.56), and the ash content for quality indicator had the mean (x) value of (3.14). In general, the catfish glue has good binding force valuable for users.
Molecular genetic characteristics of patients with hypertrophic cardiomyopathy: a review
Authors: Yus'kiv Yu. A. , Chernova A. A. , Nikulina S. Yu. , Drobot D. B. , Sakovich V. A. , Kardashova O. O.
Published: December 2024

Hypertrophic cardiomyopathy (HCM) is a diagnosis established in each case of left ventricular hypertrophy of unknown origin when the left ventricular wall is greater than or equal to 15 mm in one or more myocardial segments according to imaging data. The hereditary nature of HCM is no longer in doubt. But successful verification of HCM using genetic tests is 60% of cases. This fact makes it possible to believe that a search for new predictor genes for HCM is necessary. The review presents current literature data on mutations in genes associated with hypertrophic cardiomyopathy.
Brain-derived neurotrophic factor in the pathogenesis of comorbid coronary artery disease and depression: a review
Authors: Kytikova O. Yu. , Antonyuk M. V. , Novgorodtseva T. P. , Gvozdenko T. A.
Published: December 2024

Coronary artery disease (CAD) and depression are characterized by high bilateral comorbidity, but its pathogenesis is practically not studied.

In the last decade, neurogenic mechanisms of the inflammatory response and brain-derived neurotrophic factor (BDNF), which can explain the relationship between depression and CAD, have been studied. The review summarizes the available information on BDNF role in the pathogenesis of CAD and depression, as well as their comorbid course for the period of 2019-2024. Based on the literature review, we identified the components and systems that are most promising for studying the BDNF role in the pathogenesis of these multifactorial diseases (genetics, inflammation, neuroinflammation, endothelial dysfunction and platelet hyperactivation, hypothalamic-pituitary-adrenal system, low-density lipoproteins and triglycerides). The review emphasizes the important role of BDNF in the development of depression in CAD and the need for further research in this area.
Inflammasome - a new look at the therapy of cardiovascular diseases: a review. Part I
Authors: Rubinstein A. A. , Khodot A. A. , Tirikova P. V. , Golovkin A. S. , Kudryavtsev I. V. , Shlyakhto E. V.
Published: December 2024

In the pathogenesis of many inflammatory processes, an important role is played by a reaction cascade of various inflammasome types. The products of their activation are proinflammatory cytokines IL-1β and IL-18. These protein molecules can be secreted in two different ways as follows: by vesicular transport or by membrane pores, which subsequently leads to the secreting cell death. The role of inflammasome activation in cardiac tissue cells has not been sufficiently studied at present. However, there are some studies reflecting the association between the inflammasome cascade launch and cardiovascular diseases. Thus, inflammasome activation in cardiomyocytes can lead to electrolyte imbalance, which subsequently leads to ectopic foci in the cardiac tissue and cardiac arrhythmia. Triggering the inflammasome cascade in cardiac fibroblasts promotes fibrosis and myocardial tissue remodeling, which leads to disruption of heart functional activity. Inflammasome activation in coronary artery endothelial cells leads to endothelial dysfunction and atherogenesis. Thus, activation of various types of inflammasomes in cardiac tissue leads to cardiac pathology.
Concordância interobservadores na implementação do Acolhimento e Classificação de Risco em Obstetrícia
Authors: Velho Manuela Beatriz , Pimentel Luciana Santos , Silva Fernanda Amâncio Soares da , Trapani Junior Alberto , Ventura Thayná , Almeida Adaiana Fátima , Costa Roberta , Knobel Roxana
Published: December 2024

RESUMO Objetivos: analisar a concordância interobservadores na implementação do protocolo de Acolhimento e Classificação de Risco em Obstetrícia. Métodos: estudo transversal, realizado durante a implementação do Acolhimento e Classificação de Risco em Obstetrícia, conduzido em hospital terciário no sul do Brasil com 891 participantes em janeiro de 2020. Realizou-se análise descritiva e de concordância interobservadores pelo coeficiente de Kappa na classificação de risco atribuída pelo enfermeiro classificador e revisada pelo pesquisador. Resultados: cerca de metade dos atendimentos (55,6%) foi classificada como pouco urgente (verde), seguida de urgente (amarelo) (31,8%), muito urgente (laranja) (9,3%), não urgente (azul) (3,4%) e nenhuma classificação emergente (vermelha). Análise de concordância da classificação revisada encontrou valores de Kappa 0,20 (azul), 0,54 (verde) 0,77 amarelo e 0,80 (laranja). Conclusões: a maioria dos atendimentos foi pouco urgente. A análise de concordância entre a classificação de risco revisada e atribuída revelou maior concordância interobservador conforme aumentou o grau de prioridade.
Associação entre estado nutricional e estado funcional de idosos residentes em comunidade: uma revisão sistemática
Authors: da Silva Gabriela Avelino , Silva Vanessa de Lima , de Medeiros Géssica Cazuza , Silva Andressa Laís Ferreira , Moreira Rafael da Silveira
Published: December 2024

Resumo Introdução: O envelhecimento populacional é um fenômeno mundial que vem acontecendo de forma progressiva e exponencial nos países desenvolvidos e em desenvolvimento. Objetivo: Avaliar a associação entre estado nutricional e estado funcional de idosos residentes em comunidade presente em estudos epidemiológicos analíticos. Método: Revisão sistemática utilizando as bases de dados Lilacs, Pubmed, Web of Science e Embase, com os seguintes descritores: "idoso", "idoso de 80 anos ou mais", "estado nutricional", "desnutrição", "obesidade" e "atividades cotidianas". Foram identificados 4.411 artigos, selecionados por pares em duas fases: leitura de resumos e leitura de textos completos. Ao final foram incluídos 30 estudos. Resultados: Foram incluídos 15 estudos transversais e 15 coortes. Quanto à medida do estado nutricional, foram identificados 28 artigos que utilizaram o IMC e dois a MAN®. Para a medida da funcionalidade, as principais atividades avaliadas foram: Atividades Básicas da Vida Diária (ABVD), Atividades Instrumentais da Vida Diária (AIVD) e Atividades Avançadas da Vida Diária (AAVD), com maior frequência das ABVD. Duas classificações do estado nutricional apresentaram associação com a estado funcional: desnutrição e obesidade, sendo a obesidade a classificação do estado nutricional mais frequente. Conclusões: a maioria dos estudos mostrou associação significativa entre obesidade e dependência funcional para as ABVD, AIVD e AAVD. Quanto à desnutrição, esta demonstrou associação significativa com dependência funcional para as ABVD e AIVD.
Autoavaliação de saúde dos idosos não institucionalizados da cidade de São Paulo / Brasil sob a perspectiva da cor da pele / raça
Authors: Moura Roudom Ferreira , Cesar Chester Luiz Galvão , Goldbaum Moisés , Okamura Mirna Namie , Antunes José Leopoldo Ferreira
Published: December 2024

Resumo Introdução: A autoavaliação de saúde caracteriza-se como um indicador multidimensional utilizado no mundo. Objetivo: Analisar a autoavaliação negativa de saúde entre idosos, bem como as variáveis sociodemográficas, socioeconômicas, comportamentais e as condições de saúde. Método: Estudo transversal, de base populacional, com amostra probabilística por conglomerados, que utilizou dados do inquérito de saúde realizado em São Paulo/SP. A medida de associação foi a razão de prevalência e os respectivos intervalos de confiança de 95%. Foram estimadas razões de prevalências ajustadas por meio de regressão múltipla de Poisson, usando o modo survey do software Stata 14. Resultados: Participaram do estudo 1.017 idosos. A autoavaliação negativa de saúde foi mais prevalente entre os idosos negros (pardos — 45,5% e pretos — 47,2%). Além disso, a autoavaliação negativa de saúde dos idosos associou-se com a cor da pele preta, menor escolaridade, ausência de plano de saúde privado, falta de prática de atividade física, hipertensão e outras doenças crônicas. Conclusão: Esses resultados confirmam o caráter pluridimensional da autoavaliação negativa de saúde e apontam para a necessidade de maior atenção aos segmentos socialmente mais vulneráveis, assim como o desenvolvimento de estratégias de promoção da saúde entre os idosos, em especial, os negros.
Percepções de gestantes sobre atenção pré-natal em município do interior paulista
Authors: Fabbro Márcia Regina Cangiani , Santos Fernanda Maranho , Wernet Monika , Bussadori Jamile Claro de Castro , Souza Bruna Felisberto de , Paes Luciana Braz de Oliveira , Bravo Juliane de Souza , Boas Allison Scholler de Castro Vilas
Published: December 2024

Resumo Introdução Persistem desigualdades e inequidades no cuidado pré-natal enquanto ação programática da atenção primária em saúde, em que necessidades de saúde das mulheres não são levadas em consideração. A implementação de práticas baseadas em evidências, com enfoque no cuidado centrado nas mulheres, reproduz experiências positivas e impacta na percepção de qualidade do pré-natal. Objetivo O objetivo do estudo foi analisar as percepções de gestantes acerca da atenção pré-natal. Método Trata-se de pesquisa qualitativa sustentada nos referenciais do interacionismo simbólico e análise temática. Entrevista semiestruturada, em encontro único, com 30 gestantes usuárias de Unidades Básicas de Saúde, em um município do interior paulista, entre 2018/19. Resultados Três categorias temáticas detalham os achados: “Atenção pré-natal: protocolar e inexpressiva participação da enfermagem”, “(In)satisfação nas interações com o profissional médico” e “Entraves no apoio informacional”. A percepção de mulheres foi descrita enquanto cumprimento de rotinas protocolares e em um espaço de insuficiências relacionais entre profissionais e gestantes, limitada no alcance das singularidades, além de denunciar situações que se configuram como violência obstétrica. Conclusão Há necessidade pungente de avivar reflexões sobre transformação dos serviços de saúde em um espaço para o exercício dos direitos como pessoas e cidadãos, com apostas dialógicas, na escuta qualificada e valorização da gestante em sua integralidade.
Large Language Models (LLMs): A systematic study in Administration and Business
Authors: Pessanha Gabriel Rodrigo Gomes , Vieira Alessandro Garcia , Brandão Wladmir Cardoso
Published: December 2024

Abstract Purpose: With the advancement of the use of LLMs, there is a growing need to understand the current research scenario and potential trends and gaps in this field of knowledge. Therefore, bibliometric analysis was used with the aim of analyzing scientific production involving applications of LLMs in Administration and Business. Originality/value: This study analyzes the characteristics of academic production involving LLMs, Administration, and Business and provides potential insights for researchers and professionals in the field. Design/methodology/approach: To achieve the objectives of this work, bibliometrics and systematic mapping were conducted from 2000 to 2024 to answer the following questions: What is the state of the art of academic production involving LLMs in Administration and Business? What is the state of the art of empirical studies involving LLMs in Administration and Business? What is the focus of LLM applications in Administration and Business? Findings: Most articles involve computational modeling and empirical analyses and refer to validating existing technologies, methods, or tools. The research was classified according to 6 categories regarding the application objectives of LLMs: Tracking, Recognition, Extraction, Modeling, Summarization, and Classification. The systematic map analysis indicates that, despite advances in the use and application of LLMs, some challenges persist and represent possibilities for future research. Issues involving data ethics and privacy and the management of research biases involving natural language processing are prominent challenges.
O DESVELAMENTO DA DIMENSÃO DO IMPOSSÍVEL ATRAVÉS DA ARTE: ANALOGIAS ENTRE A SUBLIMAÇÃO EM PSICANÁLISE E O ATO CRIADOR DE MARCEL DUCHAMP
Authors: Carvalho Bruno Moreira Nonino de , Tavares Leandro Anselmo Todesqui
Published: December 2024

RESUMO: O presente artigo visa abordar a impossibilidade de representação da Coisa subjacente aos objetos criados e a elucidação da sublimação como o destino pulsional capaz de revelar a estrutura faltante do aparelho psíquico, especialmente, via a peculiaridade da arte. Além disso, objetiva-se a produção de analogias entre a formulação de Lacan acerca da sublimação como elevação de um objeto à dignidade da Coisa e a descrição do mecanismo subjetivo e subjacente à coisa artística pelo artista Marcel Duchamp, através de seu esclarecimento da essência do “ato criador”.