bluuebunny/crossref_metadata_2025 huggingface dataset:
Mothers with Intellectual/Developmental Disabilities and Behavioral Health Conditions and Community Experts Provide Recommendations for Treatment/Services, Systems, and Research
Authors: Nicholson Joanne , Mazel Shayna , Faughnan Kristen , Silverman Allie
Published: May 2023

Mothers with intellectual and developmental disabilities (IDD) are vulnerable to perinatal complications and adverse outcomes. Their vulnerabilities may also be exacerbated by co-occurring behavioral health (BH) conditions. Their wellbeing may be compromised by a lack of tailored treatments or by treatments and services that are inaccessible, irrelevant, and/or ineffective. A five-session virtual Ideas Lab workshop series was implemented to bring together diverse community experts (n = 30), including mothers with IDD/BH, to discuss the experiences of mothers and set priorities for treatment/services, systems, and research. Participants completed background and evaluation surveys and brainstormed, grouped, and ranked items of importance, which fell into two broad categories: (1) cross-cutting themes drawn from lived experience with recommendations applicable to all substantive domains (i.e., accessibility, diversity, adverse experiences and trauma, and trust) and (2) substantive themes with specific recommendations for treatment/services and systems (i.e., services and supports, peer support, provider practices and training, and systems navigation/transformation). Research recommendations were generated in all discussions and emerged in relation to all themes, underscoring the importance of including mother-driven questions and priorities in research agendas and strengthening researcher training and skills to engage mothers with IDD/BH and other community members actively, and in meaningful ways.
COVID-19-Related Testing, Knowledge and Behaviors among Severe and Chronic Non-Communicable Disease Patients in Neno District, Malawi: A Prospective Cohort Study
Authors: Zaniku Haules Robbins , Aron Moses Banda , Vrkljan Kaylin , Tyagi Kartik , Ndambo Myness Kasanda , Banda Gladys Mtalimanja , Nyirongo Revelation , Mphande Isaac , Mailosi Bright , Talama George , Munyaneza Fabien , Connolly Emilia , Dullie Luckson , Barnhart Dale A. , Ruderman Todd
Published: May 2023

COVID-19-related knowledge and behaviors remain essential for controlling the spread of disease, especially among vulnerable patients with advanced, chronic diseases. We prospectively assessed changes over 11 months in COVID-19-related testing, knowledge, and behaviors among patients with non-communicable diseases in rural Malawi using four rounds of telephone interviews between November 2020 to October 2021. The most commonly reported COVID-19-related risks among patients included visiting health facilities (35–49%), attending mass gatherings (33–36%), and travelling outside the district (14–19%). Patients reporting having experienced COVID-like symptoms increased from 30% in December 2020 to 41% in October 2021. However, only 13% of patients had ever received a COVID-19 test by the end of the study period. Respondents answered 67–70% of the COVID-19 knowledge questions correctly, with no significant changes over time. Hand washing, wearing face masks and maintaining a safe distance were the most frequently reported strategies to prevent the spreading of COVID-19. Wearing face masks significantly improved over time (p < 0.001). Although the majority reported accurate knowledge about COVID-19 and enhanced adherence to infection prevention measures over time, patients commonly visited locations where they could be exposed to COVID-19. Government and other stakeholders should increase COVID-19 testing accessibility to primary and secondary facilities.
Decision-Making and Abuse, What Relationship in Victims of Violence?
Authors: Lausi Giulia , Burrai Jessica , Baldi Michela , Ferlazzo Fabio , Ferracuti Stefano , Giannini Anna Maria , Barchielli Benedetta
Published: May 2023

Gender-Based violence is a worldwide persisting phenomenon: during their lifetime, 30% of women have experienced sexual and/or physical violence. The literature has investigated for several years the association between abuse and possible psychiatric and psychological consequences which may occur even after many years. The most common consequences involve mood and stress disorders (e.g., depression and PTSD). These disorders seem to have secondary long-term effects, such as decision-making and cognitive function impairments. Therefore, the present literature synthesis aimed to investigate whether and how the decision-making capacities of individuals experiencing violence can change because of abuse. We conducted a thematic synthesis using PRISMA guidelines: through a double-blind procedure, 4599 studies were screened; a total of 46 studies were selected for full-text reading, which was reduced to 13 by excluding papers with a wrong focus. To better understand the results of the thematic synthesis, two main focuses have been identified: “leave or stay decision making” and “multifactorial dimensions of decision making”. Results showed that decision-making is an important process in avoiding secondary victimization.
The Essential Role of Light-Induced Autophagy in the Inner Choroid/Outer Retinal Neurovascular Unit in Baseline Conditions and Degeneration
Authors: Pinelli Roberto , Ferrucci Michela , Berti Caterina , Biagioni Francesca , Scaffidi Elena , Bumah Violet Vakunseth , Busceti Carla L. , Lenzi Paola , Lazzeri Gloria , Fornai Francesco
Published: May 2023

The present article discusses the role of light in altering autophagy, both within the outer retina (retinal pigment epithelium, RPE, and the outer segment of photoreceptors) and the inner choroid (Bruch’s membrane, BM, endothelial cells and the pericytes of choriocapillaris, CC). Here autophagy is needed to maintain the high metabolic requirements and to provide the specific physiological activity sub-serving the process of vision. Activation or inhibition of autophagy within RPE strongly depends on light exposure and it is concomitant with activation or inhibition of the outer segment of the photoreceptors. This also recruits CC, which provides blood flow and metabolic substrates. Thus, the inner choroid and outer retina are mutually dependent and their activity is orchestrated by light exposure in order to cope with metabolic demand. This is tuned by the autophagy status, which works as a sort of pivot in the cross-talk within the inner choroid/outer retina neurovascular unit. In degenerative conditions, and mostly during age-related macular degeneration (AMD), autophagy dysfunction occurs in this area to induce cell loss and extracellular aggregates. Therefore, a detailed analysis of the autophagy status encompassing CC, RPE and interposed BM is key to understanding the fine anatomy and altered biochemistry which underlie the onset and progression of AMD.
Calcium’s Role in Orchestrating Cancer Apoptosis: Mitochondrial-Centric Perspective
Authors: Moon Dong-Oh
Published: May 2023

Calcium is an essential intracellular messenger that plays a vital role in controlling a broad range of cellular processes, including apoptosis. This review offers an in-depth analysis of calcium’s multifaceted role in apoptosis regulation, focusing on the associated signaling pathways and molecular mechanisms. We will explore calcium’s impact on apoptosis through its effects on different cellular compartments, such as the mitochondria and endoplasmic reticulum (ER), and discuss the connection between calcium homeostasis and ER stress. Additionally, we will highlight the interplay between calcium and various proteins, including calpains, calmodulin, and Bcl-2 family members, and the role of calcium in regulating caspase activation and pro-apoptotic factor release. By investigating the complex relationship between calcium and apoptosis, this review aims to deepen our comprehension of the fundamental processes, and pinpointing possible treatment options for illnesses associated with imbalanced cell death is crucial.
Hematopoietic System under Physiological Conditions and Following Hematopoietic Reconstitution or Stress
Authors: Kalashnikova Maria , Belyavsky Alexander
Published: May 2023

The hematopoietic system performs the most vital functions in the human body, integrating the work of various organs while producing enormous numbers of mature cells daily [...]
Signal Pathways and microRNAs in Osteosarcoma Growth and the Dual Role of Mesenchymal Stem Cells in Oncogenesis
Authors: Todosenko Natalia , Khlusov Igor , Yurova Kristina , Khaziakhmatova Olga , Litvinova Larisa
Published: May 2023

The major challenges in Osteosarcoma (OS) therapy are its heterogeneity and drug resistance. The development of new therapeutic approaches to overcome the major growth mechanisms of OS is urgently needed. The search for specific molecular targets and promising innovative approaches in OS therapy, including drug delivery methods, is an urgent problem. Modern regenerative medicine focuses on harnessing the potential of mesenchymal stem cells (MSCs) because they have low immunogenicity. MSCs are important cells that have received considerable attention in cancer research. Currently, new cell-based methods for using MSCs in medicine are being actively investigated and tested, especially as carriers for chemotherapeutics, nanoparticles, and photosensitizers. However, despite the inexhaustible regenerative potential and known anticancer properties of MSCs, they may trigger the development and progression of bone tumors. A better understanding of the complex cellular and molecular mechanisms of OS pathogenesis is essential to identify novel molecular effectors involved in oncogenesis. The current review focuses on signaling pathways and miRNAs involved in the development of OS and describes the role of MSCs in oncogenesis and their potential for antitumor cell-based therapy.
The Controversial Roles of Areca Nut: Medicine or Toxin?
Authors: Liu Pei-Feng , Chang Yung-Fu
Published: May 2023

Areca nut (AN) is used for traditional herbal medicine and social activities in several countries. It was used as early as about A.D. 25-220 as a remedy. Traditionally, AN was applied for several medicinal functions. However, it was also reported to have toxicological effects. In this review article, we updated recent trends of research in addition to acquire new knowledge about AN. First, the history of AN usage from ancient years was described. Then, the chemical components of AN and their biological functions was compared; arecoline is an especially important compound in AN. AN extract has different effects caused by different components. Thus, the dual effects of AN with pharmacological and toxicological effects were summarized. Finally, we described perspectives, trends and challenges of AN. It will provide the insight of removing or modifying the toxic compounds of AN extractions for enhancing their pharmacological activity to treat several diseases in future applications.
RNA Regulatory Networks 2.0
Authors: Enguita Francisco J. , Leitão Ana Lúcia , Mattick John S.
Published: May 2023

The central role of RNA molecules in cell biology has been an expanding subject of study since the proposal of the “RNA world” hypothesis 60 years ago [...]
CNS-Related Effects Caused by Vanadium at Realistic Exposure Levels in Humans: A Comprehensive Overview Supplemented with Selected Animal Studies
Authors: Ścibior Agnieszka , Llopis Juan , Dobrakowski Paweł Piotr , Męcik-Kronenberg Tomasz
Published: May 2023

Neurodegenerative disorders, which are currently incurable diseases of the nervous system, are a constantly growing social concern. They are progressive and lead to gradual degeneration and/or death of nerve cells, resulting in cognitive deterioration or impaired motor functions. New therapies that would ensure better treatment results and contribute to a significant slowdown in the progression of neurodegenerative syndromes are constantly being sought. Vanadium (V), which is an element with a wide range of impacts on the mammalian organism, is at the forefront among the different metals studied for their potential therapeutic use. On the other hand, it is a well-known environmental and occupational pollutant and can exert adverse effects on human health. As a strong pro-oxidant, it can generate oxidative stress involved in neurodegeneration. Although the detrimental effects of vanadium on the CNS are relatively well recognized, the role of this metal in the pathophysiology of various neurological disorders, at realistic exposure levels in humans, is not yet well characterized. Hence, the main goal of this review is to summarize data on the neurological side effects/neurobehavioral alterations in humans, in relation to vanadium exposure, with the focus on the levels of this metal in biological fluids/brain tissues of subjects with some neurodegenerative syndromes. Data collected in the present review indicate that vanadium cannot be excluded as a factor playing a pivotal role in the etiopathogenesis of neurodegenerative illnesses, and point to the need for additional extensive epidemiological studies that will provide more evidence supporting the relationship between vanadium exposure and neurodegeneration in humans. Simultaneously, the reviewed data, clearly showing the environmental impact of vanadium on health, suggest that more attention should be paid to chronic diseases related to vanadium and to the assessment of the dose–response relationship.
Extracellular-Vesicle-Based Therapeutics in Neuro-Ophthalmic Disorders
Authors: Massoumi Hamed , Amin Sohil , Soleimani Mohammad , Momenaei Bita , Ashraf Mohammad Javad , Guaiquil Victor H. , Hematti Peiman , Rosenblatt Mark I. , Djalilian Ali R. , Jalilian Elmira
Published: May 2023

Extracellular vesicles (EVs) have been recognized as promising candidates for developing novel therapeutics for a wide range of pathologies, including ocular disorders, due to their ability to deliver a diverse array of bioactive molecules, including proteins, lipids, and nucleic acids, to recipient cells. Recent studies have shown that EVs derived from various cell types, including mesenchymal stromal cells (MSCs), retinal pigment epithelium cells, and endothelial cells, have therapeutic potential in ocular disorders, such as corneal injury and diabetic retinopathy. EVs exert their effects through various mechanisms, including promoting cell survival, reducing inflammation, and inducing tissue regeneration. Furthermore, EVs have shown promise in promoting nerve regeneration in ocular diseases. In particular, EVs derived from MSCs have been demonstrated to promote axonal regeneration and functional recovery in various animal models of optic nerve injury and glaucoma. EVs contain various neurotrophic factors and cytokines that can enhance neuronal survival and regeneration, promote angiogenesis, and modulate inflammation in the retina and optic nerve. Additionally, in experimental models, the application of EVs as a delivery platform for therapeutic molecules has revealed great promise in the treatment of ocular disorders. However, the clinical translation of EV-based therapies faces several challenges, and further preclinical and clinical studies are needed to fully explore the therapeutic potential of EVs in ocular disorders and to address the challenges for their successful clinical translation. In this review, we will provide an overview of different types of EVs and their cargo, as well as the techniques used for their isolation and characterization. We will then review the preclinical and clinical studies that have explored the role of EVs in the treatment of ocular disorders, highlighting their therapeutic potential and the challenges that need to be addressed for their clinical translation. Finally, we will discuss the future directions of EV-based therapeutics in ocular disorders. Overall, this review aims to provide a comprehensive overview of the current state of the art of EV-based therapeutics in ophthalmic disorders, with a focus on their potential for nerve regeneration in ocular diseases.
Membrane Proteomics to Understand Enhancement Effects of Millimeter-Wave Irradiation on Wheat Root under Flooding Stress
Authors: Komatsu Setsuko , Hamada Kazuna , Furuya Takashi , Nishiuchi Takumi , Tani Masahiko
Published: May 2023

Millimeter-wave irradiation of wheat seeds enhances the growth of roots under flooding stress, but its mechanism is not clearly understood. To understand the role of millimeter-wave irradiation on root-growth enhancement, membrane proteomics was performed. Membrane fractions purified from wheat roots were evaluated for purity. H+-ATPase and calnexin, which are protein markers for membrane-purification efficiency, were enriched in a membrane fraction. A principal-component analysis of the proteomic results indicated that the millimeter-wave irradiation of seeds affects membrane proteins in grown roots. Proteins identified using proteomic analysis were confirmed using immunoblot or polymerase chain reaction analyses. The abundance of cellulose synthetase, which is a plasma-membrane protein, decreased under flooding stress; however, it increased with millimeter-wave irradiation. On the other hand, the abundance of calnexin and V-ATPase, which are proteins in the endoplasmic reticulum and vacuolar, increased under flooding stress; however, it decreased with millimeter-wave irradiation. Furthermore, NADH dehydrogenase, which is found in mitochondria membranes, was upregulated due to flooding stress but downregulated following millimeter-wave irradiation even under flooding stress. The ATP content showed a similar trend toward change in NADH dehydrogenase expression. These results suggest that millimeter-wave irradiation improves the root growth of wheat via the transitions of proteins in the plasma membrane, endoplasmic reticulum, vacuolar, and mitochondria.
Analysis of the Ischemia-Modified Albumin as a Potential Biomarker for Cardiovascular Damage in Obstructive Sleep Apnea Patients with Acute Coronary Syndrome
Authors: Resano-Barrio Pilar , Alfaro Enrique , Solano-Pérez Esther , Coso Carlota , Cubillos-Zapata Carolina , Díaz-García Elena , Romero-Peralta Sofía , Izquierdo-Alonso Jose Luis , Barbé Ferran , García-Rio Francisco , Sánchez-de-la-Torre Manuel , Mediano Olga ,   on behalf of the Spanish Sleep Network
Published: May 2023

Obstructive sleep apnea (OSA) has been identified as a cardiovascular (CV) risk factor. The potential of OSA promoting the synthesis of CV biomarkers in acute coronary syndrome (ACS) is unknown. Ischemia-modified albumin (IMA) has been identified as a specific CV biomarker. The aim of this study was to evaluate the role of IMA as a potential biomarker for determining the impact of OSA in ACS patients. A total of 925 patients (15.5% women, age: 59 years, body mass index: 28.8 kg/m2) from the ISAACC study (NCT01335087) were included. During hospitalization for ACS, a sleep study for OSA diagnosis was performed and blood samples extraction for IMA determination were obtained. IMA values were significantly higher in severe OSA (median (IQR), 33.7 (17.2–60.3) U/L) and moderate (32.8 (16.9–58.8) U/L) than in mild/no OSA (27.7 (11.8–48.6) U/L) (p = 0.002). IMA levels were very weakly related to apnea–hypopnea index (AHI) as well as hospital and intensive care unit stay, although they only maintained a significant relationship with days of hospital stay after adjusting for sex, age and BMI (ß = 0.410, p = 0.013). The results of the present study would suggest a potentially weaker role of OSA in the synthesis of the CV risk biomarker IMA in patients with ACS than in primary prevention.
A Novel Insect Overwintering Strategy: The Case of Mealybugs
Authors: Vercher Rosa , González Sandra , Sánchez-Domingo Adrián , Sorribas Juan
Published: May 2023

Insects have limited ability to regulate their body temperature and have thus required a range of strategies to withstand thermally stressful environments. Under unfavorable winter conditions, insects often take refuge under the soil surface to survive. Here, the mealybug insect family was selected for the study. Field experiments were performed in fruit orchards in eastern Spain. We used specifically designed floor sampling methods combined with fruit tree canopy pheromone traps. We found that in temperate climates, the large majority of the mealybugs move from the tree canopy to the roots during the winter, where they turn into belowground root-feeding herbivores to survive and continue underground the reproductive process. Within the rhizosphere, mealybugs complete at least one generation before emerging on the soil surface. The preferred area to overwinter is within 1 m in diameter around the fruit tree trunk, where more than 12,000 mealybug flying males per square meter can emerge every spring. This overwintering pattern has not previously been reported for any other group of insects showing cold avoidance behavior. These findings have implications at the winter ecology level but also at the agronomical level since treatments to control mealybug pests are, until now, only based on the fruit trees’ canopy.
Addition of Resolvins D1 or E1 to Collagen Membranes Mitigates Their Resorption in Diabetic Rats
Authors: Almogy Michal , Moses Ofer , Schiffmann Nathan , Weinberg Evgeny , Nemcovsky Carlos E. , Weinreb Miron
Published: May 2023

Uncontrolled diabetes is characterized by aberrant inflammatory reactions and increased collagenolysis. We have reported that it accelerates the degradation of implanted collagen membranes (CM), thus compromising their function in regenerative procedures. In recent years, a group of physiological anti-inflammatory agents called specialized pro-resolving lipid mediators (SPMs) have been tested as a treatment for various inflammatory conditions, either systemically or locally, via medical devices. Yet, no study has tested their effect on the fate of the biodegradable material itself. Here, we measured the in vitro release over time of 100 or 800 ng resolvin D1 (RvD1) incorporated into CM discs. In vivo, diabetes was induced in rats with streptozotocin, while buffer-injected (normoglycemic) rats served as controls. Resolvins (100 or 800 ng of RvD1 or RvE1) were added to biotin-labeled CM discs, which were implanted sub-periosteally over the calvaria of rats. Membrane thickness, density, and uniformity were determined by quantitative histology after 3 weeks. In vitro, significant amounts of RvD1 were released over 1–8 days, depending on the amount loaded. In vivo, CMs from diabetic animals were thinner, more porous, and more variable in thickness and density. The addition of RvD1 or RvE1 improved their regularity, increased their density, and reduced their invasion by the host tissue significantly. We conclude that addition of resolvins to biodegradable medical devices can protect them from excessive degradation in systemic conditions characterized by high degree of collagenolysis.
Hydrodynamics and Sediment-Transport Pathways along a Mixed-Energy Spit-Inlet System: A Modeling Study at Chincoteague Inlet (Virginia, USA)
Authors: Georgiou Ioannis Y. , Messina Francesca , Sakib Md Mohiuddin , Zou Shan , Foster-Martinez Madeline , Bregman Martijn , Hein Christopher J. , Fenster Michael S. , Shawler Justin L. , McPherran Kaitlyn , Trembanis Arthur C.
Published: May 2023

Tidal-inlet systems are dynamic features that respond to short-term (e.g., storms) and longer-term processes (e.g., sea-level rise, changes in tidal prism). The Chincoteague Inlet system, located along the northern Eastern Shore of Virginia (USA), is a dynamic coastal complex that experiences rapid change associated with sediment redistribution and a shifting inlet throat due to the southern elongation of adjacent Assateague Island. In this study, a numerical model based on Delft3D with coupled flow–waves, multiclass sediment transport, and morphologic feedback was developed to quantify the hydrodynamic and geomorphic controls within this rapidly evolving inlet–spit system and to develop a more comprehensive understanding of regional to local controls on sediment-transport pathways. Model results show that most of the sand transport along southern Assateague Island is sequestered nearshore and proximally in deeper sinks within Fishing Point, and, of that, only finer sand sizes are transported around the spit, confirming previous analysis and hypothesis. The model also showed that sand transport toward the south increases along Wallops Island and quantified spatially explicit transport trends for selected sediment classes, revealing that coarser sediment bypassing is a punctuated process that is proportional to storms.
Clinical Features and Treatment Progress of Invasive Mucormycosis in Patients with Hematological Malignancies
Authors: Yang Nuobing , Zhang Lining , Feng Sizhou
Published: May 2023

The incidence rate of invasive mucormycosis (IM) in patients with hematological malignancies (HMs) is increasing year by year, ranging from 0.07% to 4.29%, and the mortality rate is mostly higher than 50%. With the ongoing pandemic of COVID-19, COVID-19-associated mucormycosis (CAM) also became a global health threat. Patients with high risk factors such as active HMs, relapsed/refractory leukemia, prolonged neutropenia may still develop breakthrough mucormycosis (BT-MCR) even under the prophylaxis of Mucorales-active antifungals, and such patients often have higher mortality. Rhizopus spp. is the most common genus associated with IM, followed by Mucor spp. and Lichtheimia spp. Pulmonary mucormycosis (PM) is the most common form of IM in patients with HMs, followed by rhino-orbital-cerebral mucormycosis (ROCM) and disseminated mucormycosis. The prognosis of IM patients with neutrophil recovery, localized IM and receiving early combined medical–surgical therapy is usually better. As for management of the disease, risk factors should be eliminated firstly. Liposome amphotericin B (L-AmB) combined with surgery is the initial treatment scheme of IM. Those who are intolerant to L-AmB can choose intravenous formulations or tablets of isavuconazole or posaconazole. Patients who are refractory to monotherapy can turn to combined antifungals therapy.
Neuroimaging of Cryptococcal Meningitis in Patients without Human Immunodeficiency Virus: Data from a Multi-Center Cohort Study
Authors: Anjum Seher H. , Bennett John E. , Dean Owen , Marr Kieren A. , Hammoud Dima A. , Williamson Peter R.
Published: May 2023

Background: A clearer understanding is needed about the use of brain MRI in non-HIV patients with cryptococcal meningitis. Methods: Cerebral CT and MRI were studied in 62 patients in a multicenter study of cryptococcal meningitis in non-HIV patients. CT was performed in 51 and MRI in 44. MRI results are reported for the images read at NIH for 29 of the 44 patients. CT reports obtained from the original REDCap database were added to calculate the incidence of normal findings. Results: CTs were read as normal in 24 of 51 (47%), MRIs were normal in 10% (three of 29). The most characteristic lesions of cryptococcal meningitis on MRI were small basal ganglia lesions representing dilated perivascular spaces in 24% and basal ganglia lesions with restricted diffusion (infarcts) in 38%. In the 18 patients who received contrast, contrast-enhancing lesions, likely representing masses of cryptococci and inflammatory cells, were found in the basal ganglia in 22% and elsewhere in the brain in 22%. Meningeal enhancement was seen in 56%, ependymal enhancement in 24%, and choroid plexus enhancement in 11%. Hydrocephalus was found in five (18%), though increased intacranial pressure was not detected. Suboptimal imaging (n = 6), lack of contrast administration (n = 11) and lack of follow-up, however, markedly limited the accurate assessment of abnormalities in multiple cases. Conclusion: MRI characteristics of non-HIV cryptococcal meningitis include hydrocephalus, meningeal and ependymal enhancement and basal ganglia lesions. Optimal imaging is, however, necessary to maximize the diagnostic and prognostic usefulness of MRI.
Bidirectional Association between Psoriasis and Asthma: A Systematic Review and Meta-Analysis
Authors: Garcia Ashley , Ramdass Prakash V. A. K. , Ramos-Nino Maria E.
Published: May 2023

Background: Studies have shown an increased risk of asthma in patients with psoriasis and vice versa. Thus, we conducted a meta-analysis to estimate the pooled association between these two chronic inflammatory diseases. Methods: A systematic search of the literature was conducted through March 2023. Risk ratios (RRs) and prevalence were calculated. Results: A total of 11 studies comprising 110,978 patients with psoriasis and 1,898,071 controls were included in the first meta-analysis. The prevalence of asthma in patients with psoriasis was 9.2% (0.075, 0.110), and the pooled risk ratio (RR) was 1.43 (1.23,1.66). Subgroup analysis showed that older patients (≥50 years) have a higher pooled risk of asthma [RR 1.59 (1.41, 1.79)] than younger patients (20–49 years) [RR 1.23 (1.07,1.41)]. In addition, a significantly higher risk of asthma was seen in patients with moderate to severe psoriasis [RR 1.48 (1.17, 1.88)) when compared to their controls than those with mild psoriasis [RR 1.28 (1.14, 1.44)]. A total of 3 studies comprising 468,869 asthma patients and 11,063,349 control were included in the second meta-analysis. The prevalence of psoriasis in asthma patients was 1.3%, 0.004, 0.029), and the pooled risk ratio was 1.23 (1.02,1.47). Conclusions: This meta-analysis provides clear evidence for the bidirectional association between asthma and psoriasis.
A Luxury Tourist Destination in Housing for Tourist Purposes: A Study of the New Airbnb Luxe Platform in the Case of Marbella
Authors: Carrasco-Santos María Jesús , Peña-Romero Andrea , Guerrero-Navarro Daniel
Published: May 2023

Marbella has a wide range of luxury property rentals, which are the subject of study within the framework of the collaborative economy, where the Airbnb platform stands out as the most used channel. This research focuses on the analysis of the total number of luxury villas offered in Marbella by Airbnb Luxe and Luxury Retreats. The methodology was carried out in four phases: the first phase involved a review of the literature on tourism and luxury and a study of Marbella as a luxury destination. The second phase focused on the analysis of the types of accommodation that Marbella offers. The third phase focused on the collection of data from the analyzed platform: Airbnb Luxe and Luxury Retreats. Finally, qualitative research consisting of in-depth interviews with owners and real estate agents focused on the luxury sector in Marbella was carried out. The results obtained yield relevant conclusions: Marbella is one of the main luxury holiday destinations in Spain, and the most demanded type of luxe accommodation in Marbella is large luxury villas. The term ‘luxury’ can be subjective, referring to such things as the visible and non-visible aspects that determine the category of a luxury property, hence the need to carry out a study on the luxury segment to establish a precise definition.
Study on Spatiotemporal Evolution and Driving Forces of Habitat Quality in the Basin along the Yangtze River in Anhui Province Based on InVEST Model
Authors: Cao Yong , Wang Cheng , Su Yue , Duan Houlang , Wu Xumei , Lu Rui , Su Qiang , Wu Yutong , Chu Zhaojun
Published: May 2023

The basin along the Yangtze River in Anhui Province is an important ecological protective screen in the Yangtze River Delta Economic Belt, with a large number of wetlands, lakes, and nature reserves in the basin. The effect of the rapid development of regional urbanization on the ecological environment quality has become an important threat source that restricts ecosystem function and biodiversity protection in the basin. Therefore, this study used InVEST model to analyze the spatial and temporal evolution of habitat quality based on remote sensing image data from 1990, 2000, 2010, and 2020 in the basin along the Yangtze River in Anhui Province and revealed the spatial evolution trend of habitat quality degradation by using hot and cold spot analysis methods. The geographical detector model was used to discuss the main driving factors of habitat quality change. The study results showed that a trend of increase and decrease of construction land and paddy land in the basin from 1990 to 2020 was the opposite, that is, the area of construction land increased, and the area of paddy land decreased. Especially, the area of construction land increased from 390.18 km2 in 1990 to 1616.34 km2 in 2020. The area of increase and decrease of other land types remained around 1% to 2%. During the period from 2000 to 2020, Construction land was mainly transferred in from paddy land, accounting for over 60% of the area transferred in, which indicated the continuous increase of human activity intensity in the study area. From 1990 to 2020, the areas with a significant decline in habitat quality in the basin were mainly concentrated along the Yangtze River and in the northern part of the Chaohu Lake. The area proportion with the lowest grade of habitat quality showed a trend of increasing year by year, that is, the area proportion increased from 4.85% in 1990 to 8.47% in 2020. The hot spots of habitat quality degradation were concentrated in Hefei and its surrounding areas, while the cold spots of the degradation were mainly concentrated in the southern and western mountainous areas. Land use type was the main driving factor affecting habitat quality, and the interaction between land use and per capita GDP was the main driving factor for changes in habitat quality. The study results had important theoretical and practical value for the ecological environment protection and harmonious development of the relationship between humans and nature in the basin along the Yangtze River in Anhui Province.
Reduplication in Kua’nsi
Authors: Huang Huade
Published: May 2023

This paper investigates reduplication in Kua’nsi, a Central Ngwi language of the Sino-Tibetan family, spoken in Yunnan Province, China, by around 5000 speakers. Reduplication is a productive morphological device in Kua’nsi and has complex forms and functions. Although Kua’nsi reduplication shows some similarities with reduplication in other Ngwi languages, it also has reduplicative forms and functions that appear to be cross-linguistically rare. Formally, reduplication in Kua’nsi can be full, partial, or discontinuous. Functionally, it can be used with inflectional and derivational meanings as well as without any semantic or syntactic effect in certain constructions. Some functions of Kua’nsi reduplication appear to be not frequently found across languages. The forms and functions of Kua’nsi reduplication are complex and there is not a one-to-one relationship between the form and function of particular patterns of reduplication.
In Situ Observation of the Grain Growth Behavior and Martensitic Transformation of Supercooled Austenite in NM500 Wear-Resistant Steel at Different Quenching Temperatures
Authors: Li Zhongbo , Yuan Qing , Xu Shaopu , Zhou Yang , Liu Sheng , Xu Guang
Published: May 2023

In situ observations of the austenite grain growth and martensite transformations in developed NM500 wear-resistant steel were conducted via confocal laser scanning high-temperature microscopy. The results indicated that the size of the austenite grains increased with the quenching temperature (37.41 μm at 860 °C → 119.46 μm at 1160 °C) and austenite grains coarsened at ~3 min at a higher quenching temperature of 1160 °C. Furthermore, a large amount of finely dispersed (Fe, Cr, Mn)3C particles redissolved and broke apart at 1160 °C, resulting in many large and visible carbonitrides. The transformation kinetics of martensite were accelerated at a higher quenching temperature (13 s at 860 °C → 2.25 s at 1160 °C). In addition, selective prenucleation dominated, which divided untransformed austenite into several regions and resulted in larger-sized fresh martensite. Martensite can not only nucleate at the parent austenite grain boundaries, but also nucleate in the preformed lath martensite and twins. Moreover, the martensitic laths presented as parallel laths (0~2°) based on the preformed laths or were distributed in triangles, parallelograms, or hexagons with angles of 60° or 120°.
Study of Abrasive Water Jet Machining as a Texturing Operation for Thin Aluminium Alloy UNS A92024
Authors: Bañon Fermin , Sambruno Alejandro , Mayuet Pedro F. , Gómez-Parra Álvaro
Published: May 2023

Surface modification of metallic alloys can create hydrophilic or hydrophobic surfaces that enhance the functional performance of the material. For example, hydrophilic surfaces have improved wettability, which improves mechanical anchorage in adhesive bonding operations. This wettability is directly related to the type of texture created on the surface and the roughness obtained after the surface modification process. This paper presents the use of abrasive water jetting as an optimal technology for the surface modification of metal alloys. A correct combination of high traverse speeds at low hydraulic pressures minimises the power of the water jet and allows for the removal of small layers of material. The erosive nature of the material removal mechanism creates a high surface roughness, which increases its surface activation. In this way, the influence of texturing with and without abrasive has been evaluated, reaching combinations where the absence of abrasive particles can produce surfaces of interest. In the results obtained, the influence of the most relevant texturing parameters between hydraulic pressure, traverse speed, abrasive flow and spacing has been determined. This has allowed a relationship to be established between these variables and surface quality in terms of Sa, Sz and Sk, as well as wettability.
Discrete Element Simulation of the Relationship between
Composition, ITZ Property, and Tensile Behavior of
Eco-Friendly UHPC Matrix
Authors: Zhou Xiang , Shi Ye , Hu Qingchun , Zhang Shen , Zhang Xihong , Meng Lingzhen
Published: May 2023

To combat global warming, the development of eco-friendly ultra-high performance concrete (UHPC) has become one of the current research hotspots. Understanding the relationship between composition and performance of eco-friendly UHPC from a meso-mechanical point will be of great significance in proposing a more scientific and effective mix design theory. In this paper, the 3D discrete element model (DEM) of an eco-friendly UHPC matrix was constructed. The mechanism of the effect of the interface transition zone (ITZ) properties on the tensile behavior of an eco-friendly UHPC matrix was studied. The relationship between composition, ITZ property, and tensile behavior of eco-friendly UHPC matrix was analyzed. The results show that ITZ strength influences the tensile strength and cracking behavior of eco-friendly UHPC matrix. The effect of ITZ on the tensile properties of eco-friendly UHPC matrix is more significant than that of normal concrete. The tensile strength of UHPC will be increased by 48% when the ITZ property is changed from normal condition to perfect. Improving the reactivity of the binder system of UHPC will improve the performance of ITZ. The cement content in UHPC was reduced from 80% to 35%, and the σITZ/σPaste was reduced from 0.7 to 0.32. Both nanomaterials and chemical activators can promote the hydration reaction of the binder material, which in turn leads to better ITZ strength and tensile properties for an eco-friendly UHPC matrix.
Numerical Calculation of High-Strength-Steel Saddle Plate Forming Suitable for Lightweight Construction of Ships
Authors: Wang Shun , Dai Jinliang , Wang Ji , Li Rui , Wang Jiayan , Xu Zhikang
Published: May 2023

With the demand for construction of lightweight ships and polar ships, high-strength steel is increasingly applied in shipbuilding. There are a large number of complex curved plates to be processed in ship construction. The main method for forming a complex curved plate is line heating. A saddle plate is an important type of double-curved plate, which affects the resistance performance of the ship. The existing research on high-strength-steel saddle plates is lacking. To solve the problem of forming for high-strength-steel saddle plates, the numerical calculation of line heating for a EH36 steel saddle plate was studied. By combining it with a line heating experiment of low-carbon-steel saddle plates, the feasibility of numerical calculation based on the thermal elastic–plastic theory for high-strength-steel saddle plates was verified. Under the premise that the processing conditions such as the material parameters, heat transfer parameters, and the constraint mode of the plate were correctly designed, the effects of the influencing factors on deformation of the saddle plate could be studied by the numerical calculation method. The numerical calculation model of line heating for high-strength-steel saddle plates was established, and the effects of geometric parameters and forming parameters on shrinkage and deflection were studied. This research can provide ideas for the lightweight construction of ships and provide data support for automatic processing of curved plates. It can also provide inspiration for curved plate forming in fields such as aerospace manufacturing, the automotive industry, and architecture.
Active Training Control Method for Rehabilitation Robot Based on Fuzzy Adaptive Impedance Adjustment
Authors: Hu Jie , Zhuang Yuantao , Meng Qiaoling , Yu Hongliu
Published: May 2023

For lower limb rehabilitation robots, different patients or patients in different rehabilitation stages have different motion abilities, and the parameters of the traditional impedance control model are fixed and cannot achieve the best active suppleness training effect. In this paper, an active training control method based on the spring damping model (SDM) and the fuzzy adaptive adjustment of its parameters is proposed. The SDM offsets the target trajectory according to the patient interaction force to obtain a new desired trajectory, creating a controllable impedance environment for the patient. Fuzzy rules are established using coefficients reflecting the patient’s motion ability to adaptively adjust the stiffness and damping coefficients of the SDM. The virtual human–machine force interaction environment is changed to achieve the adaptive adjustment of the resistance training difficulty on the motion ability. The adaptive impedance control method proposed in this paper has achieved the expected goal through experimental verification, which can greatly mobilize the active participation of patients and help improve the rehabilitation effect of patients.
Influence of High Viscosity and Magnetoviscous Effect on the Washout Resistance of Magnetic Fluid
Authors: Li Zixian , Li Decai , Li Yanwen , Han Shuntao
Published: May 2023

Magnetic fluid seals have long been thought to be a successful sealing form while sealing liquids are always a challenge. The instability of the liquid–liquid interface under the washout has become the key technical problem that hinders the realization of sealing liquid. This work mainly presents an experimental study about the influence of high viscosity and magnetoviscous effects on washout resistance. Three engine oil-based magnetic fluids of different viscosities were prepared with two kinds of surfactants. The magnetoviscous effects of the prepared magnetic fluids under different working conditions were found through rheological experiments. The viscosity of the three samples decreased at most by about 100 times with the shear rate increasing. An experimental platform was designed and built for the washout tests. The entire process of magnetic fluids being washed away was obtained experimentally. The magnetic fluid of higher viscosity can remain stationary with lower magnetic force. The quantitative results show that the viscosity of the magnetic fluid has a significant influence on washout resistance under a magnetic field.
Wide Awake Local Anesthesia No Tourniquet Surgery of Carpal Tunnel Syndrome: Patients’ Experience and Recall Bias in a Day-Care Setting
Authors: Knystautas Saulius , Braziulis Kęstutis , Zacharevskij Ernest , Varkalys Karolis , Šimatonienė Violeta , Pilipaitytė Loreta
Published: May 2023

Background and Objective: Wide-Awake Local Anesthesia No Tourniquet (WALANT) is a technique of local anesthesia commonly used in the surgical treatment of a wide variety of conditions affecting the upper extremity, including Carpal Tunnel Syndrome (CTS). The recent retrospective studies investigated patient experiences in a wide variety of hand disorder-related cases. The aim of our study is to evaluate patient satisfaction regarding open surgical treatment for CTS using the WALANT technique. Material and Methods: we enrolled 82 patients with CTS without medical record of surgical treatment for CTS. For WALANT, a hand surgeon used a combination of 1:200,000 epinephrine, 1% lidocaine, and 1 mL 8.4% sodium bicarbonate solution without tourniquet application and sedating the patient. All patients were treated in a day-care setting. For assessment of patient experience, Lalonde’s questionnaire was adapted. Participants completed survey twice: one month and six months after the surgical treatment was performed. Results: the median pre-operative pain score for all patients was 4 (range 0–8) after one month and 3 (range 1–8) after six months. The median intraoperative pain score for all patients was 1 (range 0–8) after one month and 1 (range 1–7) after six months. The median post-operative pain score for all patients was 3 (range 0–9) after one month and 1 (range 0–8) after six months. More than half (61% after one month and 73% after six months) of the patients responded by stating that their real experience of WALANT was better than their initial expectations. An absolute majority of patients (95% after one month and 90% after six months) would recommend WALANT treatment to their relatives. Conclusions: overall, patient satisfaction with treatment for CTS using WALANT is high. Furthermore, complications related to the performed treatment and persistent post-operative pain could be associated with more reliable patient recall of this healthcare intervention. A longer period of time between intervention and assessment of patient experience could possibly be a reason for recall bias.