bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial Intelligence–Based Ethical Hacking for Health Information Systems: Simulation Study
Authors: He Ying , Zamani Efpraxia , Yevseyeva Iryna , Luo Cunjin
Published: January 2023

Background

Health information systems (HISs) are continuously targeted by hackers, who aim to bring down critical health infrastructure. This study was motivated by recent attacks on health care organizations that have resulted in the compromise of sensitive data held in HISs. Existing research on cybersecurity in the health care domain places an imbalanced focus on protecting medical devices and data. There is a lack of a systematic way to investigate how attackers may breach an HIS and access health care records.

Objective

This study aimed to provide new insights into HIS cybersecurity protection. We propose a systematic, novel, and optimized (artificial intelligence–based) ethical hacking method tailored specifically for HISs, and we compared it with the traditional unoptimized ethical hacking method. This allows researchers and practitioners to identify the points and attack pathways of possible penetration attacks on the HIS more efficiently.

Methods

In this study, we propose a novel methodological approach to ethical hacking in HISs. We implemented ethical hacking using both optimized and unoptimized methods in an experimental setting. Specifically, we set up an HIS simulation environment by implementing the open-source electronic medical record (OpenEMR) system and followed the National Institute of Standards and Technology’s ethical hacking framework to launch the attacks. In the experiment, we launched 50 rounds of attacks using both unoptimized and optimized ethical hacking methods.

Results

Ethical hacking was successfully conducted using both optimized and unoptimized methods. The results show that the optimized ethical hacking method outperforms the unoptimized method in terms of average time used, the average success rate of exploit, the number of exploits launched, and the number of successful exploits. We were able to identify the successful attack paths and exploits that are related to remote code execution, cross-site request forgery, improper authentication, vulnerability in the Oracle Business Intelligence Publisher, an elevation of privilege vulnerability (in MediaTek), and remote access backdoor (in the web graphical user interface for the Linux Virtual Server).

Conclusions

This research demonstrates systematic ethical hacking against an HIS using optimized and unoptimized methods, together with a set of penetration testing tools to identify exploits and combining them to perform ethical hacking. The findings contribute to the HIS literature, ethical hacking methodology, and mainstream artificial intelligence–based ethical hacking methods because they address some key weaknesses of these research fields. These findings also have great significance for the health care sector, as OpenEMR is widely adopted by health care organizations. Our findings offer novel insights for the protection of HISs and allow researchers to conduct further research in the HIS cybersecurity domain.
Optimasi sifat organoleptik, indeks, dan beban glikemik formula enteral berbasis tepung tempe dan tepung bengkuang
Authors: Rahadiyanti Ayu , Nissa Choirun , Annisa Wahyu Ilmi , Wijayanti Lilis , Dieny Fillah Fithra , Fitranti Deny Yudi
Published: January 2023

Optimization of organoleptic, glycemic index, and a load of enteral formula based on tempe and jicama flourBackground: Tempeh and jicama have the potential effect as hypoglycemic agents. Hyperglycemic patients are recommended to consume formula with a low glycemic index to control blood glucose levels properly. Although balancing and roasting could improve the aromas of tempeh flour, research is lacking on tempeh powder-based enteral formula.Objective: This study aimed to analyze the organoleptic, glycemic index, and glycemic load of enteral formulas based on tempeh and jicama flour to meet the requirements of enteral formulas for hyperglycemic patients.Methods: Experimental research with 3 levels of treatment, namely variations in the ratio of tempeh flour and jicama flour with formulas 1 (1:1); 2 (3:2); and 3 (4:7) with two methods, namely steam blanching and roasting before tempeh drying. An organoleptic test using a hedonic test was carried out on 25 semi-trained panelists. One-shot case study glycemic index and glycemic load test on 30 subjects met the inclusion criteria. Data analysis used the Kruskal-Wallis test.Results: The color, aroma, and taste in formula 3 were acceptable to the panelists, but the texture was less favorable. Formula 3 has a glycemic index of 55.20 and a glycemic load of 14.90. There was no difference in an index and glycemic load in the 3 enteral formulas.Conclusion: Formula 3, with a ratio of 4:7, a moderate glycemic index, and load, could be acceptable to the panelists.
Political Polarization dan Political Disinformation
Authors: Kriswantoro Thomas , Ayuning Endah , Reswara Ardhana , Zidan Ahmad
Published: January 2023

Artikel ini membahas tentang polarisasi politik dan disinformasi politik dalam rangkaian agenda pelemahan KPK yang berdampak pada perilaku politik masyarakat di Twitter. Artikel ini menggunakan konsep political polarization, political disinformation, dan political behavior. Tulisan ini menggunakan metode big data analysis untuk pengambilan data dan analisis data. Selanjutnya, metode tersebut digunakan untuk mengidentifikasi dan memetakan polarisasi isu, isi wacana, dan aktor sebagai opinion leader. Artikel ini juga melakukan pemetaan dan analisis kritis tentang narasi yang diproduksi di media sosial, khususnya Twitter. Wacana dan aktor dalam rangkaian agenda pelemahan KPK disoroti melalui tiga peristiwa, yaitu peristiwa Revisi Undang-Undang KPK, terpilihnya Ketua KPK Firli Bahuri, dan Tes Wawasan Kebangsaan. Temuan yang disampaikan di tulisan ini, yaitu polarisasi politik di antara kelompok pro pemerintah dan oposisi pemerintah dan disinformasi politik yang diproduksi dengan membawa isu taliban dan isu radikalisme. Pada akhirnya, perilaku politik masyarakat dalam agenda pelemahan KPK cenderung melekatkan diri pada influencer yang memiliki orientasi politik yang serupa.
POTENTIAL ANTIOXIDANT EFFICACY OF THE SECONDARY METABOLITES ISOLATED FROM CALOCYBE INDICA (VAR.APK2): AN EDIBLE MACROFUNGI
Authors: AKBAR BATCHA PARVEEN NISHA , KUMUTHAKALAVALLI R.
Published: January 2023

Objective: Mushrooms have been valued as traditional sources of natural bioactive compounds for many centuries and targeted as promising therapeutic agents. The bioactive mycomolecules of mushrooms are reported to have antioxidant, antitumor, antidiabetic, anti-inflammatory, and antimicrobial activity, which are the important medicinal targets in terms of drug discovery today. Hence, an attempt was made in the present study, to evaluate the immunomodulatory and oxidative process of secondary metabolites from the milky mushroom Calocybe indica (P&C) var.APK2 using radical scavenging assays.
Methods: The fruiting bodies of milky mushrooms were found to produce an array of mycomolecules such as phenols, flavonoids, alkaloids, tannins, terpenoids, steroids, and saponins in their methanolic extract which was confirmed using Fourier-transform infrared spectrophotometer (FT-IR) analysis and standard phytochemical studies; hence, chromatography fractions of these mushroom seem greatly promising biological activities including antioxidants.
Results: The functional analysis of the secondary metabolites of these macrofungi was evaluated by the separation of potential fractions using preparative thin-layer chromatography (TLC) that revealed seven distinct bands with Rf values of 0.14, 0.26, 0.31, 0.42, 0.52, 0.70, and 0.82; the antioxidant activity was determined through TLC in situ bio autography. The quenching property of metabolite compound which was ranging from 19% to 77.9% and the half effective concentration values of 2,2-diphenyl-1-picrylhydrazyl and hydroxyl radical scavenging activity was recorded as 64.26 μg/ml and 54.5 μg/ml sample concentration, respectively. The active mycomolecules of C. indica from the TLC was, further, confirmed using Gas Chromatography–Mass Spectrometry studies.
Conclusion: The present investigation of the study revealed that the antioxidant efficacy of edible milky mushroom may be further proceeded for in vivo studies for novel drug discovery.
INVESTIGATION OF FOOD POISONING OUTBREAK IN A TEMPORARY CAMP USING MIXED METHODOLOGY APPROACH
Authors: SR MANJUNATH , RAVISHEKAR N HIREMATH , VISWANATH KASI
Published: January 2023

Objectives: In the present study, a food poisoning outbreak was reported from a medical officer in-charge of the temporary camp, where a largegathering of around 400 boys and girls had consumed meal from a common kitchen during training event. Thus, the main objective of the study was to investigate the outbreak and institute preventive measures.
Methods: The camps had a total strength of 400. Ten individuals reported with history of vomiting and diarrhea. Mixed methodology approach was used to carry out epidemiological investigation. Inspection of cookhouse and surroundings was carried out.
Results: Ten individuals were affected. A short incubation period ranging from 4 to 6 h with median incubation of 5 h. Among cases, all had diarrhea with the number of episodes ranging from 3 to 5. Seven patients had vomiting (70%), two (20%) patients had blood in stools, and none reported with abdominal cramps and fever. A total of five food items were suspected for food poisoning. However, none had a significant association with outcome. In depth interview and descriptive analysis revealed that mayonnaise in sandwich was the cause for food poisoning.
Conclusion: Food poisoning outbreak is a common occurrence now days. Hygiene and sanitation of cookhouse to be carried out routinely to prevent outbreak. Individuals in camps should also be educated of 5 Key points of food safety by the WHO.
FORMULATION DEVELOPMENT AND OPTIMIZATION OF EMPAGLIFLOZIN FILM COATED TABLET USING QUALITY-BY-DESIGN APPROACH
Authors: LAKAMBARE SHRADDHA , ATUL PHATAK  , MAHESH BHADAGALE  , VARDHAMAN BAFNA
Published: January 2023

Objective: Development of robust and effective oral solid immediate release film coated tablet of empagliflozin using Quality-by-Design (QbD) approach was the objective of present research work. This belongs to Sodium Glucose Co-Transporter-2 inhibitors-oral hypoglycemic class to treat Type-2 diabetes mellitus and associated cardiovascular comorbidities.
Methods: Assessment of risk factors (using Ishikawa fishbone diagram) was done by in-depth understanding of quality target product profile and critical quality attributes (CQAs) associated with material and process with justification. Randomized regular two levels full factorial design in addition with 5-center points was employed as Design of Experiment (DoE) tool. In this design, independent factors were concentrations of hydroxyl propyl cellulose (HPC SL) and croscarmellose sodium in mg. The responses selected for study were % drug release at 15-min in vitro dissolution time, disintegration time in sec, and hardness in Newton.
Results: ANOVA and lack-of-fit demonstrated that stipulated independent variables have significant impact on response variables and best correlation was seen in actual and predicted value. This optimization method confirmed that HPC SL (8 mg) and croscarmellose sodium (4 mg) were ideal concentrations of binder and disintegrant, respectively, to prepare said formulation with desired quality attributes and it was found to be better with respect to stability and effectiveness against marketed reference formulation.
Conclusion: QbD tools such as QTPP, CQAs, risk assessment, and DoE can be used in combination to optimize, screen, and understand the function of material and process parameters on quality characteristics of film-coated tablet.
TO STUDY THE RISK FACTORS ASSOCIATED WITH METABOLIC SYNDROME IN CORONARY ARTERY DISEASE PATIENTS
Authors: KAUR JASPREET , KAUR JASWANT , MITTAL MRIDULA , SINGH TEJINDER , GUPTA VISHAL
Published: January 2023

Objective: Indians are more likely to develop metabolic syndrome (MetS). The additive predictive value of MetS components for cardiovascular disease is still under debate. The current study aimed to study the risk factors associated with MetS in coronary artery disease (CAD) patients.
Methods: This retrospective study was conducted in the Department of Biochemistry in collaboration with the Department of Medicine, Noida International Institute of Medical Sciences, Gautam Buddha Nagar, Up on 100 patients already diagnosed with CAD, attending medicine OPD and IPD. Anthropometric measurements, and estimation of fasting blood glucose, high-density lipoprotein-cholesterol, and triglycerides were done. MetS prevalence was estimated as per the guidelines of NCEP ATP III.
Results: In our study, we observed a high incidence of MetS in patients with CAD. MetS was diagnosed, gender-wise distribution resulted in 62% in females and 48% in males. Risk factors for MetS in CAD patients were highly significant with increasing age, sedentary lifestyle, and diabetes. Waist circumference, fasting blood glucose levels, and triacylglycerol were found to have a significant *p<0.001 value with MetS in CAD patients.
Conclusions: The current study found a strong link between MetS and its risk factors in CAD patients. Thus, the assessment of MetS and its components might help identify people at a higher risk of advancing CAD in the future. Hence, effective MetS management may significantly reduce morbidity and mortality due to CAD.
CLINICAL PROFILE AND OUTCOME OF CHILDREN WITH SEVERE ACUTE MALNUTRITION ADMITTED AT NUTRITIONAL REHABILITATION CENTER OF MCCH-ASSOCIATED HOSPITAL OF GMC-ANANTNAG
Authors: MAJID ANDLEEB , HUSSAIN MALIK SHAKIR , NAJAR BILAL AHMAD , TALI SHOWKAT HUSSAIN , GULZAR SUMAIRA
Published: January 2023

Objectives: The objectives of this study were to study the clinical profile and outcome of children Admitted in NRC of MCCH-associated hospital of GMC-Anantnag.
Methods: Children in the age group of 1 month-5 years, admitted to NRC of our hospital between April 2019 and May 2022 with severe acute malnutrition (SAM) were enrolled for the study. As per a predesigned pro forma, a detailed history was taken from mothers or caregivers and nutritional status assessment using standard anthropometric methods was performed. Classification of malnutrition was made according to the WHO guidelines. Anthropometric measurements including weight in kg and length/height in cm, weight for height, Z score, mid-upper arm circumference, and presence of edema were used to classify the grades of malnutrition. After basic workup and starting nutrition rehabilitation, serial weight gain was recorded. Outcome of patients (home discharge, referral to higher center, and death) was recorded and analyzed.
Results: A total of 306 children with SAM admitted to NRC of our hospital were enrolled for the study. Majority were of 7–12 months of age (n=93; 30.4%), of female gender (n=178; 58.2%), were from nuclear families and from families with spacing between two children <2 years. SAM was more among children of illiterate and unskilled parents and of parents in the lower and upper lower socioeconomic status (288, 94%). Acute gastroenteritis (n=206; 67.32%) and acute respiratory tract infection (n=158; 51.6%) were most predominant comorbidities seen among hospitalized children. Hypoglycemia (n=183; 59.80%) and hypokalemia (n=56; 18.30%) were most common metabolic derangements. Among the admitted children 119 (38.88%) had good weight gain (10 mg/kg/day), 136 (44.44%) had moderate weight gain (5-10gm/kg/day) and 51 (16.66%) had poor weight gain (<5 g/kg/day). Out of 306 children admitted, 276 (91%) children were discharged after successful rehabilitation and 27 (9%) were transferred to higher center. No death was documented among SAM children during the study period.
Conclusion: Malnutrition in under five children is high and multi-factorial. Hospital-based management of SAM is an important step in reducing the morbidity and mortality among such children.
TIME USE PATTERNS IN CHILDREN WITH AND WITHOUT CHILDHOOD OBESITY
Authors: BABATUNDE RAJI ROQEEB , REGE SUMITA , CHAVAN SHASHIDHAR
Published: January 2023

Objective: The aim of the study was to compare the daily time use patterns of children with and without childhood overweight and obesity.
Methods: Participants from schools in the Udupi district within the age group of 8–15 years were recruited. These children’s body mass index was measured to categorize them into obese and non-obese group. Information about activity participation was then collected from parent and their children using a week-long 24 hr time diary. Data pertaining to time spent on play participation (active) and other daily activities were extracted from the log diaries to gain an understanding of the activity participation for children with and without obesity.
Result: The results indicate that, for play activities, miscellaneous activities and sleep, a statistically significant mean difference existed for the time spent in each activity between the two groups with the non-obese group having higher values in each. However, participants in the obese group have higher value regarding the time spent in sedentary behaviours.
Conclusion: The findings from this study showed that time use patterns in children with and without childhood obesity differs.
INFLUENCE OF PRE MENSTRUAL SYNDROME ON AUTONOMIC FUNCTIONS OF HEART IN YOUNG ADULT FEMALES – A CROSS-SECTIONAL STUDY
Authors: ANR LAKSHMI , S ARULRAJA , NAGARAJAN POORNIMA KUMBAKONAM , K PRABHAVATHI , GNANADURAI THILIP KUMAR
Published: January 2023

Objective: The aim of the study was to analyze the role of autonomic activity by heart rate variability (HRV) during different phases of menstrual cycle in subject with premenstrual syndrome (PMS).
Methods: This cross-sectional study was conducted in SRM medical college hospital and research center for 6 months (November 2017 to April 2018). Sixty young female subjects with regular menstrual history aged between 18 and 25 years of age were recruited in this study after obtaining ethical committee clearance. The subjects were categorized into mild and moderate PMS according to Premenstrual Syndrome Scale. This study includes 30 subjects in each category. HRV was done by Physiopac, the “Medicaid” system during the various phases of the menstrual cycle. Statistical analysis was done by t-test (paired and independent sample test).
Results: The mean heart rate (<0.005), low frequency (LF) power normalized unit (n.u) (<0.001), and LF high frequency (HF) ratio (<0.001) were significantly increased in the luteal phase whereas the mean RR interval (<0.008), standard deviation of normal to the normal (<0.05), RMSSD (<0.037), HF power n.u (0.054), and total power (<0.055) were significantly reduced in the luteal phase of moderate PMS when compared to the luteal phase of mild PMS.
Conclusion: Disturbances in the balance of autonomic function in the late luteal phase might be responsible for the psychological and somatic changes in women with PMS.
ANTIDEPRESSANT EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA COMPARED WITH IMIPRAMINE IN MICE MODELS
Authors: DSOUZA FLOYD VERNON , M JAYARAJ , DSOUZA HALMOND MELROYD
Published: January 2023

Background: Depression was considered as mental illness worldwide. Various symptoms observed with depression are loss of interest, sad mood, disturbed sleep, low energy, and loss of appetite. Mimosa pudica is a traditional medicine having various medicinal properties. Imipramine is a tricyclic antidepressant drug used in depression. This study is to evaluate the antidepressant activity of ethanolic extract of M. pudica leaves and imipramine in mice models.
Methods: Swiss albino mice weighing 20–25 g of either sex was involved in study. In each study, the animals were divided into five groups (n=6). Drug was administered i.p. and the antidepressant activity was performed using tail suspension test (TST) and forced swim test (FST) in Group 1 – control group, Group 2 received imipramine (10 mg/kg), and Groups 3, 4, and 5 received M. pudica extract of (4, 6, 8 mg/kg).
Results: The study shows the significant reduction in immobility in acute and chronic study of TST and FST with M. pudica extract of (6 mg/kg) and imipramine when compared with control and other extracts of M. pudica (4 mg/kg and 8 mg/kg)
Conclusions: The study concluded that the ethanolic extract of M. pudica has significant antidepressant activity and can be, further, considered for the treatment of depression.
Update on the treatment of multisystem inflammatory syndrome in children associated with COVID-19
Authors: Long Fangyuan , Zhu Shiheng , Wang Zeguang , Zhang Shungeng , He Jinlong , Ge Xinbin , Ning Jun
Published: January 2023

In late 2019, SARS-CoV-2 was detected in China and spread worldwide. In rare cases, children who were infected with COVID-19 may develop multisystem inflammatory syndrome (MIS-C), which could have higher mortality than COVID-19 itself. Therefore, diagnosis and management are critical for treatment. Specifically, most of the initial treatment options of MIS-C choose intravenous immunoglobulin (IVIG) and steroids as the first-line treatment for patients. Moreover, antagonists of some cytokines are used as potential future therapeutics. Of note, therapeutic plasmapheresis can be used as a treatment for refractory severe MIS-C. We believe that each patient, especially those with comorbid conditions, should have individualized treatment based on both multidisciplinary consensus approach and expert opinion.
Uso de gestores bibliográficos entre los participantes de las capacitaciones de ALFIN de la Biblioteca Central Pedro Zulen de la UNMSM
Authors: Quispe-Farfán Gabriela A. , Rojas Lazaro Carlos Javier
Published: January 2023

El estudio se enfoca en el uso y preferencias de los gestores bibliográficos por parte de participantes en las capacitaciones de ALFIN realizadas por la Biblioteca Central de la Universidad Nacional Mayor de San Marcos, con el propósito de mejorar los programas de soporte de la biblioteca. Se envió un cuestionario en línea, se recopiló y analizó un conjunto de 953 respuestas. Los resultados revelan que sólo el 33.5 % de los participantes utilizaba los gestores bibliográficos. De ellos, el 27.6 % eran estudiantes de pregrado y el 24.1 % de posgrado, y se demostró que Mendeley (49.5 %) y Zotero (26.0 %) son los gestores más utilizados. Así también, por parte de los encuestados, el nivel de manejo es básico y de dominio regular. El 66.5 % de ellos no usa ningún gestor bibliográfico, siendo las principales causas el desconocimiento de estas herramientas y su difícil manejo. Se concluye que hay deficiencias en el uso de gestores bibliográficos, a pesar de ser una herramienta de apoyo en las competencias informacionales para el desarrollo de los trabajos de investigación.
Review on Investigation of Shear Lag Effect for EMI and PZT Technique by Using Analytical Approach
Authors: Pande Atish R , Kapoor Dr. Ankur
Published: January 2023

Abstract: The advent of smart materials such as piezoelectric (PZT) sensors has helped to revolutionize the field of structural health monitoring (SHM) based on NDT techniques. Currently, the effect of the thickness of the adhesive layer (Shear lag Effect) is considered insignificant in the practical application of EMI technology. Although a relatively new NDT method known as the electromechanical (EMI) technique has been studied for more than two decades, there are still a number of issues that must be resolved before it can be applied to real structures. A technique with significant potential to advance one of the most efficient SHM systems involves the use of a single PZT to excite and sense the host structure. This article reviews the research related to EMI technology over the past decade to understand its trend. It also compares new concepts and ideas proposed by other authors and ends the work with a discussion of possible directions for future work.
Recent Trends in the field of Biometric Security system using Digital Image Processing
Authors: Pal Koushik , Pradhan Suniket , Paul Saynee , Bera Snehasish , Das Aritra , Saha Sayani , Samanta Sneha , Banerjee Chandraima
Published: January 2023

Abstract: This paper gives an outline in security with the help of DIP(Digital Image Processing). Digital image processing technology is a heavily used technology in various fields like military, biometric, medical fields etc. Scientists try their best to upgrade this technology which helps in the future from any obstacles. In 1960 DIP was first invented at Bell Laboratory. In of case of Fingerprint, it is the evidence which plays the main role to solve criminal problems. Not only a fingerprint, face recognition and iris recognition also takes a main role to solve any criminal problems or it is also used for privacy purposes. Digital cameras take pictures with clarity and give a satisfied output to the users.
A Study on Factors Affecting the Career Maturity of College Freshmen: Focusing on the Level of Entrepreneurial Aptitude and Self-efficacy
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Eui-Tae , Kim Ju-Seuk
Published: January 2023

Objectives The purpose of this study is to explore the relationship between the factors affecting the career maturity of college freshmen enrolled in local universities, and to analyze the effect of entrepreneurial aptitude level and self-efficacy on career maturity.
Methods For this purpose, the entrepreneurship aptitude test, the job search readiness test, and the career readiness test were conducted for freshmen at University A in Chungcheong Province. In addition, descriptive statistics, correlation analysis, and multiple regression analysis were performed using a total of 257 responses.
Results First, the correlation analysis for each sub-factor of entrepreneurial aptitude level, career maturity, and job search readiness showed a positive relationship. Second, it was shown that the level of entrepreneurial aptitude and job search readiness had a positive effect on career maturity. Third, it was found that the sub-factors of self-efficacy in entrepreneurial aptitude level and job search readiness were affecting career maturity.
Conclusions Based on the main research results, it was suggested that a startup education program and a self- efficacy improvement program are needed for college freshmen at local universities.
The Effect of Flipped Learning on Critical Thinking Ability, Communication Ability, and Problem Solving Ability of Nursing College Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Moon Sook Ja
Published: January 2023

Objectives The purpose of this study was to examine the effects of flipped learning on critical thinking ability, communication ability and problem solving ability of nursing students.
Methods The subjects of this study were 91 nursing students from S University in Jeonnam. Data were collected at the first time of the first semester of the first semester on March 2, 2022, and the post-survey was conducted at the last time on June 8, 2022, after the end of the class., The collected data were statistically processed using SPSS Windows 20.0 Program.
Results Flip-learning class was found to have statistically significant effects on critical thinking ability, communication ability, and problem solving ability of nursing college students., As a result of analyzing the sub-area of each variable, critical thinking ability showed significant effect in sound skepticism, systemicity, intellectual acuity, and confidence, but there was no statistically significant difference in fairness, objectivity, and prudence., Problem solving ability was found to have significant effects on open thinking, recognition and judgment, alternative evaluation and decision.
Conclusions This study is meaningful in that it applied the flipped learning teaching method which is emerging recently to the curriculum and verified its effect. In the future, it is necessary to apply such teaching and learning method considering the curriculum of various environments and the level of students, and to investigate the effect accordingly and to add a wide range of variables.
The Effects of Gratitude Disposition on Posttraumatic Growth in (under)Graduate Student with Relational Loss: The Mediating Effects of Meaning in Life and Deliberate Rumination
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Chae-Bin , Park Kee-Hwan
Published: January 2023

Objectives The purpose of this study was to examine the role of meaning in life and deliberate rumination in the relationship between gratitude disposition and posttraumatic growth.
Methods 351 (under)graduate students who experienced relational loss completed the self-report questionnaires for Relational loss, Gratitude disposition, Meaning in Life, deliberate Rumination and Posttraumatic Growth. The data was analyzed using SPSS Statistics 26.0 and PROCESS MACRO v4.0.
Results First, gratitude disposition, meaning in life, deliberate rumination, and posttraumatic growth were all significantly correlated in a positive direction. Second, meaning in life and deliberate rumination had a simple mediating effect on the relationship between gratitude disposition and posttraumatic growth. Third, meaning in life and deliberate rumination had a sequential dual mediating effect on the relationship between gratitude disposition and posttraumatic growth.
Conclusions These finding suggested that higher gratitude disposition increased the level of meaning in life, and that leads to an increase deliberate rumination, promoting posttraumatic growth. Based on these results, clinical implications and limitations of this study were discussed.
A study on the justification of the graduation certification system through the non-curricular curriculum: Focusing on the case of S University
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Joungmin , Park Dongseong
Published: January 2023

Objectives The purpose of this study is to find a way to improve the legitimacy of the graduation certification system and human resources implemented by S University.
Methods To this end, we tried to secure the validity of the overall system operation plan and standards based on the awareness of the members of the school, and quantitative and qualitative surveys focus group interview was performed.
Results The study results are summarized as follows. First, as a result of verifying the difference between graduation certification and SCH talent products according to the general characteristics of the subjects, student number (F=5.452, p<.001), grade (F=7.996, p<.001), college (F=6.592, p<.001), recognition of graduation certificate (t=5.949, p<.001), satisfaction with non-curricular activities currently participating (t=3.207, p<.01), satisfaction with university (t)=2.725, p<.05), and there was a statistically significant difference. Second, the overall perception of talent products was low, and the expectation of effectiveness was low because the timing and number of recipients of talent products were relatively small. appeared to be
Conclusions The implication of this is that, Regarding graduation accreditation, it was confirmed that recognition was high in the grade most closely related to graduation, and there was a difference between colleges in department accreditation standards, briefing sessions, and public relations. Therefore, in order to secure the validity of scholarship payment through talent products, it is necessary to find a way to link it with students' achievement motivation.
Changing countries as a reference point for education in South Korea after PISA
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, KWON DAEUN
Published: January 2023

Objectives This paper investigate whether the PISA rankings have resulted in the shifting of USA and high ranking countries referential status in South Korea education.
Methods For the purposes of analysis, media representation and the number of articles of referential countries education in South Korea is analyzed by using a newspaper holding a high market share and diverse viewpoints from three time periods: two years before and after the first PISA release and for the last two years.
Results Referential countries are diversified from only two countries, USA and Japan, after PISA in elementary and secondary education. Articles have much less detail about USA education. USA losing considerably slowly its status as a reference point for Korea education and the pattern of Japan articles has peculiarity.
Conclusions The results of this study imply that the pattern of external referencing in media representation is affected by not only PISA but also historical, political, and cultural experiences in the case of South Korea. The world university ranking, meanwhile, has even bigger impact than PISA and cultural experience in a university education.
A Study on the Influence of Employment Specification on the Decent Job of University Student
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, OH SUNG EUN
Published: January 2023

Objectives The purposes of this study were to explore of variables related to influence decent job on university students.
Methods The purposes of this study were to analyze the crossover analysis logistic regression analysis among them.
Results The purposes of this study were to specify variables related to cross tabulation test and to analyze the influencing factor among them. The result of this study were to difference in major cat of humanities sociology. The result of this study were to influence of income of a parent to decent jog.
Conclusions University is to develop a program about career development of student according to major characteristics to the job world. and University is to support finance and program to student to prepare getting a jog.
The Current Trends in Microspheres: A Review
Authors: Ingle Tusharkumar Gautam , Pande Shrikant D. , Sawarkar Roshni , Padole Dipti
Published: January 2023

The idea of targeted drug delivery is to concentrate the treatment in the target tissues while lowering the relative concentration of the drug in the non-target tissues. As a result, the medication is concentrated at the desired location. As a result, the medication has no effect on the tissues nearby. Therefore, by combining the drug with a carrier particle like microspheres, nanoparticles, liposomes, niosomes, etc. that regulates the release and absorption characteristics of the drug, carrier technology offers an intelligent way for drug delivery. Microspheres are naturally biodegradable powders made of proteins or synthetic polymers that flow freely and preferably have a particle size of less than 200 m. If improved, it is the trustworthy method for maintaining the desired concentration at the site of interest without unfavourable effects and reliably delivering the drug to the target site with specificity. Microspheres attracted a lot of interest for their sustained release as well as their ability to direct anti-cancer medications to the tumour. Microspheres will play a key role in novel drug delivery in the future by fusing together a variety of other strategies, especially in diseased cell sorting, diagnostics, gene & genetic materials, safe, targeted, and efficient in vivo delivery, and supplements as miniature representations of diseased organs and tissues in the body.

Keywords: Microspheres, controlled release, Types of microspheres, Methods of preparation, characterisation of microspheres, applications.
RUZTYE. EXTERNAL AND INTERNAL ORGANIZATION OF TECHNICAL SERVICE IN THE AGRO-INDUSTRIAL COMPLEX
Authors:   Irkutsk State Agrarian University named after A.A. Yezhevsky, BURAEVA GALINA
Published: January 2023

The article presents the analysis of factors of management decisions in the organization of technical service of agricultural machinery. (Research purpose) The research purpose is developing a methodology for assessing external and internal factors of technical service implementation based on a SWOT analysis of a repair company. (Materials and methods) The article describes options for SWOT analysis to assess the strengths and weaknesses of a technical service enterprise, as well as opportunities and threats emanating from its environment. (Results and discussion) The organization of technical service on the results of SWOT analysis of the company activities can significantly improve the economic well-being of machine manufacturers and the reliability and resource preservation, including by reducing the work time and the list of technological operations. Development of technical service in the agro-industrial complex is determined by the monitoring and control of processes in the internal and external activities of the repair enterprise. The article presents a concept and strategy for the development of a real-time technical service system for the functioning of a service enterprise, taking into account the relationships between factors. (Conclusions) The use of SWOT analysis of engineering solutions allows you to determine the strengths and weaknesses of the repair company, as well as opportunities and threats from the environment. Quantitative and qualitative assessment of production with the use of experts working in the engineering field of agriculture and well informed in the organization and technology of technical service, allows you to find reserves for the implementation of existing opportunities and to counter threats, as well as serve as a basis in the strategic goals of technical service of machines.
CONTRIBUTION OF THE I.E. ULMAN SCIENTIFIC SCHOOL TO THE CREATION OF THE SCIENTIFIC FOUNDATIONS OF THE TECHNICAL SERVICE OF MACHINES
Authors:   Federal Scientific Agroengineering Center VIM, TSENCH YULIYA , GODLEVSKAYA ELENA ,   Chelyabinsk State Industrial and Humanitarian College named after A.V. Yakovlev
Published: January 2023

The science of repair and restoration of components and parts of agricultural machinery was actively developed in the conditions of the planned economy of the country in the 1950-1980 s. The work of the network of specialized repair plants, maintenance stations, diagnostic points deployed in all regions of the country was based on the scientific and technological basis created by domestic scientists. A great contribution to the accumulation of significant scientific and practical experience in the restoration of agricultural machinery was made by the scientific school of the Chelyabinsk Institute of Mechanization and Electrification of Agriculture, headed by I.E. Ulman. (The purpose of the study) TTo analyze the directions of research and development in the field of creating a system for organizing and carrying out maintenance and repair of agricultural machinery and to identify its role in the development of the agro-industrial complex of the region. (Materials and methods) Determined that the beginning of work I.E. Ulman is associated with the development of experimental research methods on various friction units of mechanisms and machines in the laboratory of the Leningrad Polytechnic Institute named after M.I. Kalinin and industrial training at the Putilov plant. (Results and discussion) The scientific research of the I.E. Ulman school covered the following main areas: research and development of technological processes for the restoration of worn parts by electrophysical methods; evaluation of the reliability of repaired units and restored parts by accelerated testing methods; diagnostics of mobile equipment units in the process of their repair, research and development of organizational bases for maintenance and repair of machines, restoration of worn parts of a wide range. (Conclusions) The scientific school of I.E. Ulman has made a significant contribution to the development of technologies for restoring worn-out machine parts with various coatings (galvanics, vibro-arc surfacing, baking metal powders).
68Ga-FAPI-04: the first experience of clinical application in Russia
Authors: Ivanova A. A. , Stanzhevskii A. A. , Maystrenko D. N. , Shatik S. V. , Sysoev D. S. , Antuganova Yu. O. , Nadporojskii M. A. , Antuganov D. O.
Published: January 2023

INTRODUCTION: According to the literature, 68Ga-FAPI-04 has receptor specificity for malignant neoplasms with overexpression of the fibroblast activation protein and is used to visualize various types of neoplasms, in particular head and neck cancer, gastrointestinal tract, lung, breast cancer with a high contrast ratio of the tumor to the background, and may possibly become an alternative to 18F-FDG.

OBJECTIVE: The results of the first experience of using PET/CT with 68Ga-FAPI-04 in Russia.

MATERIALS AND METHODS: A comparative analysis of the results of 68Ga-FAPI-04 and 18F-FDG PET/CTs with an interval of 1–3 days was carried out in 13 patients (four women and nine men) with various oncological diseases, examined from February to December 2021 in Granov Russian Research Center of Radiology and Surgical Technologies.

RESULTS: In all 13 patients, it was possible to identify both primary tumors and their metastases with different tracer uptake. 68Ga-FAPI PET/CT compared with 18F-FDG PET/CT revealed more metastatic foci (135 vs 127) predominantly in the liver, peritoneum, mesentery, omentum, and brain due to low background uptake in these organs. In our observation, foci of increased 68Ga-FAPI-04 uptake localized in non-enlarged retroperitoneal lymph nodes in two patients. Also, in two patients with bone metastases from bladder cancer and stomach cancer, one false positive and one false negative result was obtained with 68Ga-FAPI-04.

DISCUSSION: The high uptake of 68Ga-FAPI-04 in the tumor makes it a promising tracer for many types of cancer, especially in cases, where conventional 18F-FDG PET/CT faces limitations due to its pharmacokinetics. At the same time, PET/CT with 68Ga-FAPI-04, aimed at visualizing the tumor microenvironment, may have a higher sensitivity in detecting small lesions due to the predominance of stroma in them. 68Ga-FAPI showed better results in detecting both lytic and osteoblastic bone metastases compared to 18F-FDG.

CONCLUSION: 68Ga-FAPI is a promising tracer for molecular imaging of most malignant neoplasms and requires further study. 68Ga-FAPI-04 can become an addition or a full-fledged solution when other tracers have limitations.
Clinical value of biochemical markers and 68Ga-DOTATATE PET/CT in the follow-up of patients with pancreatic neuroendocrine tumors: a retrospective study
Authors: Nosov N. A. , Popov S. A. , Rozengauz E. V. , Stanzhevskii A. A. , Granov D. A. , Maystrenko D. N.
Published: January 2023

INTRODUCTION: Follow-up of patients with pancreatic neuroendocrine tumors (p-NETs) remains little studied and relevant. The role of tumor markers as indicators of recurrence, as well as the relationship between the prevalence of the disease in 68Ga-DOTATATE PET/CT and levels of tumor markers, has been studied in a few publications.

OBJECTIVE: To determine the significance of markers and visualization methods in the follow-up of patients with p-NETs.

MATERIALS AND METHODS: 68Ga-DOTATATE PET/CT was performed in 73 patients diagnosed with pancreatic NET: 57 patients (78%) were previously treated, 16 patients (22%) underwent primary staging. The levels of serotonin and chromogranin-A (CgA) were studied at the time of PET/CT and at the onset of the disease. CT and MRI were performed within 2 months before PET/CT. Statistics: Spearman’s coefficient was used for correlations. To determine the levels of markers at which it is recommended to enroll 68Ga-DOTATATE PET/CT, a ROC-analysis was performed. The result of the ROC-analysis is presented with a 95% confidence interval.

RESULTS: CT and MRI revealed metastases in 45 patients (61.6%), PET/CT revealed foci in 56 patients (76.7%), of which 13 patients had metastases of other anatomical locations, which were not previously detected. Sensitivity of 68Ga-DOTATATE PET/CT to pancreatic NET is 94.8%, specificity is 93.3%. In ROC-analysis, the area under the curve was 0.8 for serotonin (CI95% 0.676–0.924), for CgA 0.81 (CI95% 0.695–0.925). A weak relationship was revealed between the degree of oncomarkers increase and the number of foci: for serotonin r=0.32 (p<0.05), for CgA r=0.298 (p<0.05). No correlation was found between the number of foci and the tumor proliferative activity index (Ki67). Also, for all foci localizations, there was no dependence of SUV max on the levels of markers and Ki67.

DISCUSSION: In our study, 68Ga-DOTATATE PET/CT revealed more metastases than routine methods, due to this, the treatment plan and the volume of surgical interventions were adjusted. An increase in the levels of tumor markers highly likely indicates a relapse of the disease. However, the low Spearman correlation coefficient between the number of foci and the levels of serotonin and CgA does not allow us to assume the prevalence of the tumor process by the degree of this rise. In addition, no significant relationship was found between the prevalence of the tumor and the levels of the studied tumor markers.

CONCLUSION: 68Ga-DOTATATE PET/CT has higher accuracy in the diagnosis of p-NETs than routine imaging methods. In combination with the determination of the tumor markers levels, the probability of detecting tumor foci increases.
Predictors of radiation-induced skin reactions in patients with T-cell skin lymphomas after total skin irradiation: retrospective cohort study
Authors: Vinogradova Yu. N. , Zaslavskiy D. V. , Zelianina M. I. , Ilyin N. V.
Published: January 2023

INTRODUCTION: Skin reactions negatively affect a patient’s quality of life and may require radiation therapy premature interruption, what impairs illness control. Numerous agents determine tissue radiosensitivity, but demographic and lifestyle factors remain poorly understood. Those kind of patients herapeutic algorithm demands studies.

OBJECTIVE: Radiation-induced skin reactions (RISR) formation and severity prognostic factors determination for primary malignant skin lymphomas patients.

MATERIALS AND METHODS: 45 patients malignant T-cell skin lymphoma study, aged 38 to 82 years (29 mycosis fungoides patients, 2 lymphomatoid papulosis, 14 patients with primary anaplastic large cell skin lymphoma) received fast electrons total skin irradiation on the basis of the Federal State Institution «Russian Radiology and Surgical Technologies Scientific Center named after Academician A.M.Granov» of the Ministry of Health of the Russian Federation from 2012 to June 2022. Radiation therapy performed in the usual fractionation mode on linear electron accelerators Elekta Precise with 4–6 MeV bremsstrahlung total doses from 14 to 30 Gy (22±2.4 Gy). In order to identify the role of possible prognostic factors of skin toxicity — gender, age, body mass index (BMI), smoking status, lymphoma body surface area (BSA), the presence of concomitant diseases (diabetes mellitus and arterial hypertension) and previous chemotherapy.

Statistics: Statistical analysis was performed using the IBM SPSS Statistics v. 26 program (developed by IBM Corporation). The value of p<0.05 was considered statistically significant. Verification of the sample belonging to the normal general population was carried out using the Shapiro–Wilk criterion. Spearman's rank correlation coefficient was used for correlation analysis. The regression parameters were estimated using the least squares method.

RESULTS: The analysis revealed positive associations between the severity of RISR and predictor factors: BMI (r=0.799, p<0.01), smoking status (r=0.655, p<0.01), age (r=0.534, p<0.05), presence of diabetes mellitus (r=0.456, p<0.05), arterial hypertension (r=0.227, p<0.05), previous chemotherapy (r=0.422, p<0.01) and lymphoma body surface area (r=0.378, p<0.01). Severity of RISR scale value increase by those parameters. Negative links found between the severity of RISR and the total focal dose (SOD) of the beginning of their formation (r=–0.109, p<0.05).

CONCLUSION: Formation and severity prognostic factors for the RCC upon fast electrons total skin exposure for patients with primary malignant T-cell skin lymphomas (mycosis fungoides, lymphomatoid papulosis, primary anaplastic large cell lymphoma of the skin) were identified.