bluuebunny/crossref_metadata_2025 huggingface dataset:
DAKHIL AYAT KISAH DALAM AL-QURAN: STUDI ANALISIS KISAH HARUT DAN MARUT DALAMTAFSIR AD-DURR AL-MANTSUR KARYA JALALUDDIN AS-SUYUTHI
Authors: Misbah Muhammad
Published: July 2020

Artikel ini mengulas tentang dakhil dalam tafsir ad-Durr al-Mantsur karya Imam Jalaluddin as-Suyuthi. Penelitian ini memfokuskan pada ayat kisah tentang Harut dan Marut. Dalam menafsirkan ayat tersebut, imam Jalaluddin Suyuti memaparkan banyak riwayat-riwayat yang ketika ditelaah lebih lanjut banyak mengandung khurafat. Tafsir ad-Durr al-Mansur ini hanya sekedar memaparkan kisah tanpa ada komentar lanjutannya, apakah riwayat tersebut sahih atau bukan. Kisah tentang Harut dan Marut yang dipaparkan dalam tafsir tersebut termasuk dakhil dalam tafsir dengan kategori riwayat Israiliyyat dan hadis maudhu’.
KONSEP KEBEBASAN BERAGAMA DALAM PERSPEKTIF AL-QUR’AN (APLIKASI TAFSIR KONTEKSTUALIS QS. AL-BAQARAH: 256)
Authors: Syaifullah Najib
Published: July 2020

Artikel ini fokus terhadap kebebasan beragama dalam perspektif al-Qur’an. Islam melarang umatnya memaksa orang lain (non muslim) untuk masuk islam, manusia diberi kebebasan untuk masuk Islam atau tetap dalam kekafirannya, dengan segala akibatnya masing-masing, kebebasan beragama perspektif al-Qur’an bukanlah kebebasan yang mutlak, tetapi kebebasan yang mengandung konsekuensi hukum dan akan dipertanggung jawabkan dan diberi balasan sesuai dengan pilihan dan tindakannya, oleh karena disamping keistewaannya, akal dan hati manusia juga banyak mempunyai kelemahan dan keterbatasan maka untuk memilih jalan yang benar, manusia membutuhkan wahyu dan petunjuk Allah SWT, asas penerimaan Islam dan pelaksanaan ajaran-ajarannya adalah kehendak atau pilihan sendiri, keyakinan yang mantab dan sukarela, kebebasan beragama menurut Islam tidaklah menghalangi umat Islam untuk mengajak orang lain kepada petunjuk dan jalan Tuhan. hanya saja ajakan tersebut disampaikan dengan Hikmah, Mauidhoh Hasanah dan Mujadalah Ihsan, bukan dengan paksaan, tekanan atau kekuatan bersenjata, semua itu membuktikan bahwa Islam tidak ditegakkan dan disebarkan dengan pedang, kekerasan dan peperangan, karena Islam hanya membenarkan penggunaan kekuatan dan peperangan untuk melndungi diri dan membendung musuh atau bila terjadi pelanggaran hak-hak asasi umat Islam dan penghalangan pelaksanaan kewajiban-kewajiban mereka
Lithospheric Structure of the Central Andes Forearc from Gravity Data Modeling: Implication for Plate Coupling
Authors: Gushurst Greg , Mahatsente Rezene
Published: July 2020

Geodetic and seismological data indicates that the Central Andes subduction zone is highly coupled. To understand the plate locking mechanism within the Central Andes, we developed 2.5-D gravity models of the lithosphere and assessed the region’s isostatic state. The densities within the gravity models are based on satellite and surface gravity data and constrained by previous tomographic studies. The gravity models indicate a high-density (~2940 kg m-3) forearc structure in the overriding South American continental lithosphere, which is higher than the average density of the continental crust. This structure produces an anomalous pressure (20-40 MPa) on the subducting Nazca plate, contributing to intraplate coupling within the Central Andes. The anomalous lithostatic pressure and buoyancy force may be controlling plate coupling and asperity generation in the Central Andes. The high-density forearc structure could be a batholith or ophiolite emplaced onto the continental crust. The isostatic state of the Central Andes and Nazca plate is assessed based on residual topography (difference between observed and isostatic topography). The West-Central Andes and Nazca ridge have ~0.78 km of residual topography, indicating undercompensation. The crustal thickness beneath the West-Central Andes may not be sufficient to isostatically support the observed topography. This residual topography may be partially supported by small-scale convective cells in the mantle wedge. The residual topography in the Nazca ridge may be attributed to density differences between the subducting Nazca slab and the Nazca ridge. The high density of the subducted Nazca slab has a downward buoyancy force, while the less dense Nazca ridge provides an upward buoyancy force. These two forces may effectively raise the Nazca ridge to its current-day elevation.
Diagnostic biomarker candidates for pulpitis revealed by bioinformatics analysis of merged microarray gene expression datasets
Authors: Chen Ming , Zeng Junkai , Yang Yeqing , Wu Buling
Published: July 2020

Background: Pulpitis is an inflammatory disease, the grade of which is classified according to the level of inflammation. Traditional methods of evaluating the status of dental pulp tissue in clinical practice have limitations. The rapid and accurate diagnosis of pulpitis is essential for determining the appropriate treatment. By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. Methods: By integrating two datasets (GSE77459 and GSE92681) in the GEO database using the sva and limma packages of R, differentially expressed genes (DEGs) of pulpitis were identified. Then, the DEGs were analysed to identify biological pathways of dental pulp inflammation with Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). Protein–protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape.Results: A total of 470 DEGs comprising 394 upregulated and 76 downregulated genes were found in pulpitis tissue. GO analysis revealed that the DEGs were enriched in biological processes related to inflammation, and the enriched pathways in the KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signalling pathway and NF-κB signalling pathway. The GSEA results provided further functional annotations, including complement system, IL6/JAK/STAT3 signalling pathway and inflammatory response pathways. According to the degrees of nodes in the PPI network, 10 hub genes were identified, and 8 diagnostic biomarker candidates were screened: PTPRC, CD86, CCL2, IL6, TLR8, MMP9, CXCL8 and ICAM1.
Breastfeeding practices and complementary feeding in Ecuador: implications for localized policy applications and promotion of breastfeeding: a pooled analysis
Authors: Freire Wilma B. , Waters William F. , Roman Diana , Belmont Philippe , Wilkinson-Salamea Emily , Diaz Adrian , Palacios Ivan , Bucheli Enrique
Published: July 2020

Background: Best practices in breastfeeding are often not followed despite appropriate levels of knowledge and positive attitudes regarding the benefits of human milk. For many reasons, some women do not initiate breastfeeding, suspend breastfeeding early, or initiate complementary feeding earlier than recommended. Usual measurement methods use large sample surveys at a national scale, which are not well suited for monitoring sub-national differences. Methods: In order to understand how local infant feeding practices could influence policy and promotion practices, we apply data pooling methodology to analyse breastfeeding patterns in different Ecuadorian settings: Cumbayá parish, located near Quito, the Ecuadorian capital; the city of Macas and rural surroundings in the Amazon basin province of Morona Santiago; and the province of Galapagos. Surveys were conducted independently between August 2017 and August 2018; while they are representative of each respective setting, sampling designs and survey methods differ, but the same demographic information and data based on standard breastfeeding indicators established by WHO were collected. In order to account for differences in the different settings, the design effect of each survey was considered in the analysis. Results: Significant differences were found in breastfeeding practices between the suburban parish near Quito and Galapagos on one hand and urban and rural parts of Morona Santiago, on the other. The rates of early breastfeeding initiation and age-appropriate breastfeeding are significantly higher in urban and rural Morona Santiago then in Cumbayá or Galapagos, while the rate of exclusive breastfeeding is highest in rural parts of Morona Santiago. No significant differences were found in complementary feeding practices between Cumbayá and Galapagos, but there are with urban and rural Morona Santiago. Initiation of breastfeeding in the first hour after birth occurs in only 36.2 percent of cases in Cumbayá but in 75.4 percent of cases in urban Morona. Conclusions: Differences among regions reflect specific opportunities and barriers to practices related to promoting optimal infant health and nutrition. Consequently, regional or local conditions that often are not apparent in national-level data should orient policies and promotion activities in specific populations.
Genetic and Environmental Influences on Self-Reported Cognitive Functioning: Associations of Diverse Measures of Stress across the FMR1 CGG Repeat Range
Authors: Maltman Nell , DaWalt Leann Smith , Hong Jinkuk , Baker Mei Wang , Berry-Kravis Elizabeth M , Brilliant Murray H. , Mailick Marsha
Published: July 2020

Background: The FMR1 gene is essential for neural development and healthy synaptic function. The modal number of CGG repeats in FMR1 is 30, but the range is large with the reported copy number extending down to as few as 6 CGGs and up to over 200 CGGs. Prior work suggests that behavioral phenotypes, including cognitive function, may vary along the continuum of the FMR1 CGG repeat range. Stress also negatively influences cognitive function; however, it is not known whether FMR1-related variability (i.e., CGG repeat length), in addition to stress, independently influences cognitive function across the CGG range. Methods: Participants included 1275 mothers who had between 18 and 123 CGG repeats. Participants completed self-report measures of executive function (BRIEF-A), memory, subjective stress (i.e., perceived stress), and objective stress (i.e., number of life events, parenting a child with a disability). Stress and CGG repeat length were examined as predictors of self-reported executive function and memory difficulty. Results: Each measure of stress (i.e., perceived stress, life events, and parenting a child with a disability) significantly predicted greater self-reported difficulties in executive function and the likelihood of memory problems, net of age and level of education. Additionally, above and beyond stress effects, CGG repeat number significantly predicted executive functioning and memory difficulties. Conclusions: These findings suggest that CGG repeat length confers independent contributions to self-reported executive function difficulty and memory problems over and above indices of stress, suggesting additive effects of genetic variation and environmental exposure.
Efficacy and safety of a novel personalized navigation template in proximal femoral corrective osteotomy for the treatment of DDH
Authors: shi qiang , Sun Deyi
Published: July 2020

Background: This present study is aimed to retrospectively evaluate the efficacy and safety of a novel personalized navigation template in proximal femoral corrective osteotomy for the treatment of DDH.Methods: Twenty-nine consecutive patients with DDH who underwent proximal femoral corrective osteotomy were evaluated between August 2013 and June 2017. Based on the different surgical methods, they were divided into the conventional group (n = 14) and navigation template group (n = 15). The osteotomy degrees, radiation exposure, and operation time were compared between the two groups.Results: No major complications relating to osteotomy surgery such as redislocation or avascular necrosis occurred in the navigation template group, which had more accurate osteotomy degrees, less radiation exposure, and shorter operation time when compared with the conventional group (P<0.05). Moreover, there was significant difference according to the McKay criteria between the two groups (P=0.0362).Conclusions: The novel personalized navigation template in proximal femoral corrective osteotomy is effective and safe, which could improve the femoral osteotomy accuracy, reduce radiation exposure, and shorten operation time.
Association of the state hope and decisional conflict with the outcomes of an educational intervention to decrease cardiovascular risk in women: mixed methods study in primary health care
Authors: Petricevic Slavica Juric , Pavlicevic Ivancica , Mrduljas-Dujic Natasa , Curcic Liza , Jankovic Sanja Dosen , Skrabic Slavica , Biocina Anita Tolic , Malicki Mario , Buljan Ivan , Marusic Matko , Marusic Ana
Published: July 2020

BackgroundPatient education in lifestyle changes has a positive effect on health in individuals with cardiovascular (CV) risk. We analyzed the effect of an educational intervention on women with different menopausal status in relation to their decisional conflict (DC) about treatment for CV risk and hope that their health will improve according to desired expectations.MethodsThis prospective interventional follow-up study exposed women to the intervention consisted of a 60-minute lecture on the change of lifestyle and nutrition habits to reduce CV risk. We measured the 10-year risk of fatal cardiovascular disease (CVD) and parameters that increase CV risk, the participants filled in 3 questionnaires and six months after the intervention we collected the participants’ feedback on the intervention.ResultsOut of 104 participants, 102 (98%) completed the study. The intervention significantly decreased the 10-year risk of fatal CVD at three months from median 3.3 (95% CI = 2.6–4.3) to 2.9 (95% CI = 2.2–3.6) (P < 0.001) regardless of their menopausal status. The intervention decreased decisional conflict for all respondents after the intervention, and it remained significantly lower at 3 months, but the overall state hope did not change. Two predictive factors of reduced CV risk were identified: high 10-year risk of fatal CVD at the beginning of the study (OR = 1.58, 95% CI 1.15–2.13) and smoking status before the intervention (OR = 4.05, 95% CI 1.07–15.51).ConclusionsA brief educational intervention may be effective in reducing CV risk. Hope and decisional conflict seem not to contribute to CV risk reduction, as only poor health and smoking habits were predictive of risk reduction success.Trial registrationTrial was retrospectively registrated in CT.gov in February 28th 2019.Number of protocol: IP-2014-09-7672. Number of registration: NCT03863210.
Analysis of the Clinicopathological Features and Prognosis of Pregnancy with Gastric Cancer: A Case-Control Study
Authors: Han Ying , Lu Junli , Zhu Lei , Sang Cuiqin , Wang ShuZhen
Published: July 2020

BackgroundTo summarize the clinicopathological features and prognostic factors of pregnancy with gastric cancer.MethodsThe clinical data of pregnant patients with gastric cancer diagnosed and treated in our hospital from 2009.1 to 2019.12 were analyzed. Two sex-, age-, and stage- matched controls for each case were identified from the medical data. Clinical characteristics, pathological features and prognosis were summarized.ResultsThe median overall survival time of the pregnancy with gastric cancer and the control group were 8.0 months and 11.0 months, respectively (P = 0.05). The advanced stage was associated with poor prognostic factors. Pregnancy with gastric cancer was associated with a longer time from diagnosis to treatment (19.0 days vs 9.0 days, p = 0.012). The median age was 32 years old (26.0ཞ41.0 years old). The diagnosed time of prengnancy week was 9.0 ~ 37.0 weeks. Of 22 patients, 4 patients had gastric cancer family history. Abdominal pain (6/22, 27.3%) was the most common presentation, and other symptoms were nausea and/or vomiting (3/22, 13.6%), nonspecific dyspepsia (3 cases, 13.6%), and melena (1 case, 4.5%). Other 9 patients (41.0%) were identified with metastatic features, including abdominal distention, ascites, abdominal mass, and jaundice. 5 cases(22.7%) received curative gastrectomy, 5 patients (22.7%) received chemotherapy,and other 12 patients (54.6%) received supportive therapy. ConclusionsThe prognosis of patients with gastric cancer in pregnancy is very poor, and patients often cannot be diagnosed in time. The tumor differentiation is poor with advanced stage, always progresses rapidly with high mortality. And the tumor stage was the significant factor influecing the prognosis.
Keyhole Evacuation for moderate basal ganglia Hematoma superior than Craniotomy
Authors: Peng Lu , Zhu Qing , Lan Qing , Cheng Yuan , Liu Guodong
Published: July 2020

Background: Spontaneous intracerebral hemorrhage (SICH) is the most devastate kind of stokes.For basal ganglia hematoma with volume ranged from 30 to 60 ml, different surgical procedures have been recommended by different neurosurgeons.This study aimed to compare the clinical outcomes and hospitalization cost between keyhole surgery and craniotomy for basal ganglia intracerebral hemorrhage.Methods: A retrospective analysis was performed on clinical data of 63 cases of keyhole procedure and 56 cases of craniotomy procedure. Hematoma evacuation rate, infection rate, re-bleeding, operation time, hospitalization cost and outcome were recorded.Results: The evacuation rate was similar in keyhole group and craniotomy group (P>0.05), and infection rate was lower in keyhole group compared to craniotomy group (P<0.05). Mean operation time and hospitalization cost were less in keyhole group than in craniotomy group (P<0.05). Mortality rate between two groups showed no significant differences. The patients operated within 6h had better outcome than those operated between 6-24h (p<0.05).Conclusion: For patients with basal ganglia hematoma ranged from 30-60 ml, keyhole surgery is safe and feasible, and operation within 6 h can improve the prognosis of the patients.
Clinical and Functional Outcomes using the Kyocera Modular Limb Salvage System for Lower Extremity Reconstruction
Authors: Rubio Donnel Alexis Ting , Hayashi Katsuhiro , Yamamoto Norio , Shirai Toshiharu , Takeuchi Akihiko , Katou Hideji , Aoki Yu , Higuchi Takashi , Abdelaal Ahmed Hamed Kassem , Tsuchiya Hiroyuki
Published: July 2020

Background: Segmental metallic endoprostheses are widely used and important in reconstructive procedures of the lower limb. Most of the currently available endoprostheses are made in Europe or the United States of America and are too large for Asian knees. The Japanese Musculoskeletal Oncology Group developed a tumor prosthesis better suited for Asian skeletal anatomy, the Kyocera Modular Limb Salvage System (KLS).Methods: We performed a retrospective review of the records of patients who underwent reconstruction using KLS implants. Thirty-five patients fulfilled the inclusion criteria, 20 having undergone limb salvage surgery for tumor and 15, joint arthroplasty. Functional outcomes were evaluated using the revised Musculoskeletal rating scale for the tumor group and the Japanese Orthopedic Association Knee Score for the arthroplasty group. Complications and survivorship of the implants were also assessed.Results: At the latest follow-up, in the tumor group, 13 were alive with no evidence of recurrence, 6 died of disease, and 1 was alive with evidence of disease. The average MSTS scores on latest follow-up were 63 for the proximal femur, 67 for the distal femur, and 92 for the proximal tibia. The mean prosthesis survival was 28 months. Complications include 4 cases of aseptic loosening, 2 deep infections, 1 superficial infection, 1 valgus deformity, 2 periprosthetic fractures, 2 incidences of excessive polyethylene wear, and 2 local tumor recurrences. In the arthroplasty group, 1 patient had a persistent low grade infection on the latest follow-up. The post-operative JOA score was 61(mean). Complications included 3 cases of aseptic loosening, 2 deep infections, 2 implant failures, 1 superficial infection, 1 valgus deformity, and 1 soft tissue defect.Conclusion: Early results of the KLS implant system are encouraging, with comparable clinical outcomes to other systems in the literature. A longer follow-up study with increased numbers of patients is necessary to further validate the functional outcomes and prosthesis survival using the KLS system for limb salvage surgery.
Caring for older dependent people in low and middle-income countries: the effect of age on mental health in caregivers
Authors: Phetsitong Ruttana , Vapattawong Patama , Mayston Rosie , Prince Martin , Chua Kia-Chong
Published: July 2020

Background: Older people worldwide are living with chronic health problems, of whom 80% were from low and middle-income countries. Caregiver stress is a complex interplay of health and socio-economic factors with older caregivers, however, the effects of caregiver age upon their mental health have not been well-described. This study aimed to examine whether caregiver age predicts their mental health outcomes in terms of psychological morbidity and care burden in Latin America and China.Methods: The present study was based from cross-sectional baseline data of seven low and middle-income countries including; Cuba, Dominican Republic, Peru, Venezuela, Mexico, China, and Puerto Rico, collected between February 2003 and June 2009 by the 10/66 Dementia Research Group. Data from 1348 households where the caregiver provided care for one older person in the household were included in the current analysis. Psychological morbidity was assessed through the Self-Reporting Questionnaire. The Zarit Burden Inventory was used to measure the levels of care burden of caregivers. Multivariate logistic regression was used to investigate the effects of caregiver age upon psychological morbidity and care burden. Meta-analysis was performed to obtain pooled estimating one overall odd ratios and 95% confidence intervals of the analyses from the different countries, using the inverse-variance weighted fixed-effect method.Results: The prevalence of the household with older caregivers is almost the same level as of the households with younger caregivers in Puerto Rico and China. The models unadjusted and adjusted for all potential covariates (household size, number of household asset, caregiver sex, caregiver marital status, caregiver education, cognitive impairment of older person, functional dependency of older person, behavioral problem of older person, and caregiving hours) showed that there was no statistically significant difference in psychological morbidity and care burden between older caregivers and non-older caregivers across countries. The Adjusted pooled estimates, however, indicated lower psychological morbidity among older caregivers (OR = 0.61, 95%CI: 0.41–0.93, I2 = 0.0%).Conclusions: Older caregivers are at lower risk of mental health problem than younger caregivers. This information may help to provide a greater understanding for service support, policy makers and health care providers.
Exploring The Factors Related to the First Usage of Crystal and Providing Some Preventive Solutions: A Qualitative Study
Authors: Sighaldeh Shirin Shahbazi , Zarghami Fatemeh , Shahryari Ali , Mohammadinia Ali , Ebrahimi Mohsen , Jorjani Teimoor , Hamrah Mohammad Shoaib , Charkazi Abdurrahman
Published: July 2020

Background: Crystal (methamphetamine) usage is increasing among teenagers and young people in the country. In this matter, one of the practical and important ways to control it is to identify the causes of its first usage. Thus, in this paper, the factors related to the first usage of crystal in consumers and providing a preventive solution were designed and performed in Golestan province, Iran.Methods: In a qualitative study, 19 crystal consumers entered the study in Golestan province by snowball sampling from DIC (drop-in center) and addiction treatment centers. The interviews were mostly carried out individually with the participants, in which only one interview was conducted in an addiction treatment camp in the form of a group-focused discussion. Data analysis was implemented through content analysis in MAXQDA 10 softwareResults: The mean age of the participants was 35.05± 6.06 years with a range of 23-46 years. Meanwhile, the mean and standard deviation of usage time was 7.42±3.61 via a range of 1-14 years. Based on the obtained qualitative data, the reasons for first usage of crystal in six classes of "crystal usage to other drugs rehabilitation"; "Lack of awareness of the addictive nature of crystal"; “stimulating curiosity in public with crystal-usage friends”; “cheap price and comfortable usage”; "anti-sleep effects and increasing work efficiency" and "misconceptions (therapeutic effect), increase attractiveness, and increase sexual drive" were included.Conclusions: The achieved results indicated that crystal is mostly abused to opium rehabilitation. Meanwhile, the lack of awareness of addiction and misconceptions can prepare to crystal usage. Furthermore, performing the Interventions to increase the level of awareness that crystal is addictive and its negative impact on opium rehabilitation as well as the necessary policy-making to facilitate accessing it by reducing its production can also be effective to prevent the crystal usage.
Public perceptions of Lyme disease and climate change in southern Manitoba, Canada: Making a case for strategic decoupling of climate and health messages
Authors: Cameron Laura , Rocque Rhéa , Penner Kailey , Mauro Ian
Published: July 2020

Background: Despite scientific evidence that climate change has profound and far reaching implications for public health, translating this knowledge in a manner that supports citizen engagement, applied decision-making, and behavioural change can be challenging. This is especially true for complex vector-borne zoonotic diseases such as Lyme disease, a tick-borne disease which is increasing in range and impact across Canada and internationally in large part due to climate change. This research aims to better understand public risk perceptions of climate change and Lyme disease in order to increase engagement and motivate behavioural change.Methods: A focus group study involving 61 participants was conducted in three communities in the Canadian Prairie province of Manitoba in 2019. Focus groups were segmented by urban, rural, and urban-rural geographies, and between participants with high and low levels of self-reported concern regarding climate change. Results: Findings indicate a broad range of knowledge and risk perceptions on both climate change and Lyme disease, which seem to reflect the controversy and complexity of both issues in the larger public discourse. Participants in high climate concern groups were found to have greater climate change knowledge, higher perception of risk, and less scepticism than those in low concern groups. Participants outside of the urban centre were found to have more familiarity with ticks, Lyme disease, and preventative behaviours, identifying potential differential sources of resilience and vulnerability. Risk perceptions of climate change and Lyme disease were found to vary independently rather than correlate, meaning that high climate change risk perception did not necessarily indicate high Lyme disease risk perception and vice versa. Conclusions: This research contributes to the growing literature framing climate change as a public health issue, and suggests that in certain cases climate and health messages might be strategically decoupled when addressing climate skeptical audiences. A model showing the orthogonal relationship between Lyme disease and climate change perceptions is proposed, and implications for engagement on climate change health impacts are discussed.
Circular 3D Printing: Reprintable Polymers for Digital Light Processing Printing
Authors: Zhu Guangda , Hou Yi , Xu Jian , Zhao Ning
Published: July 2020

3D printing has become a disruptive technology and shown great potential for various practical applications. Specially, digital light processing (DLP) demonstrates advantages in high resolution and high efficiency. However, extensive production of infusible and insoluble thermosets in DLP printing causes serious resource waste and environmental problems after disposal. Herein, we report a reprintable linear polymer for circular DLP printing. Taking advantage of the dissolution of linear polymer in its monomer, printed objects can be recycled into liquid resin and reprinted via the same DLP. Polymerization kinetics and printing resolution of recycled resins, and mechanical properties of reprinted polymers retain identical as the original. Thermoplastic nature endows 3D objects with welding and reshaping property. Fully recyclable composites have also been successfully fabricated and sustainable usage of high-value fillers comes true. This strategy helps to address environmental issues arising from unprocessable thermosets and contributes to developing a circular materials economy.
Successful Outcome of Disseminated Candida Tropicalis Osteomyelitis on Remission Induction for Childhood Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia - Case Report
Authors: Xie Lichun , Long Qingling , Zhou Guichi , Liu Si-xi , Wen Feiqiu
Published: July 2020

Background: Invasive fungal infection (IFI) is one of the most challenging complications in children with acute lymphoblastic leukemia (ALL) treatment, but acute fungal osteomyelitis (OM) is rarely encountered. Case presentation: Here, we describe a case of Candida tropicalis osteomyelitis in a 10-year-old patient with Philadelphia chromosome (Ph)–positive ALL. He was on remission induction therapy at the time of neutropenia, and abscess developed in the right arm. The blood and bone cultures were positive for Candida tropicalis. Antibiotics and anti-fungal were given. A magnetic resonance of the arm revealed in intraosseous abscess, suggestive of OM. Surgical irrigation and debridement of the bone were performed immediately. The patient was effectively treated with antifungal therapy and ALL treatment. Now he full recovered into complete clinical remission but with sequelae visible by Magnetic Resonance Imaging (MRI). He took oral posaconazole for consolidation until disappearance of the lesion shadows on MRI and received subsequent cycles of chemotherapy in parallel. Conclusions: In the successful management of Ph-positive ALL, dasatinib the second-generation Abl–tyrosine kinase inhibitor is crucial. The recommended treatment for candida osteomyelitis in Ph-positive ALL patients are fungicidal agent combined with surgery and modification chemotherapy with dasatinib. Using combined modalities of treatment seem to be crucial in the successful management of Ph-positive ALL.
The Importance of Base Frame Fabrication in Microtia Reconstruction
Authors: Xu Zhicheng , Zhang Ruhong , Zhang Qun , Xu Feng , Li Datao , Li Yiyuan
Published: July 2020

Background The base frame provides stable support for the helix, antihelix, and tragus-antitragus complex in microtia reconstruction, and this support is vital to attain a highly defined outline for a reconstructed auricle. The success of base frame sculpting depends on appropriate treatment of the cartilage, mainly the sixth and seventh costal cartilages, which may have different characteristics. The aim of this study is to demonstrate the relevant details for base frame fabrication in various scenarios.Methods This study included 352 patients with microtia who underwent autologous auricular reconstruction between 2016 and 2019. Concerning the different sizes and characteristics of the costal cartilage used for base frame reconstruction, we describe related methods for fabrication and introduce corresponding strategies for proper management.Results Relevant techniques in base frame fabrication have been shown to produce favorable results. The elaborately sculpted base frame establishes a stable foundation and natural protrusion of the helix, antihelix and tragus-antitragus complex. The base frame contributes to the integrity of a harmonious appearance of the reconstructed ear.Conclusions The elaborate design and appropriate utilization of costal cartilage for base frame sculpting is one of the most significant and fundamental processes in microtia reconstruction. It contributes to achieving a clearly defined outline of the auricle with harmonious integrity, which is as important as the other projected subunits.
Percutaneous endoscopic treatment of benign and malignant renal pelvis carcinoma: A single-center experience
Authors: Zhang Xin , Han Wu Xiu , Li Sheng Yan , Chen Hao Yuan , Tang Zhe Yu , Zhang Peng , Li Tao , Wang Yuan Si
Published: July 2020

Background Percutaneous nephrolithotomy (PCNL) is a safe and efficient treatment for intro-renal diseases, most of which are calculus disease. In this study, we carried out percutaneous endoscopic nephron-sparing ablation for renal carcinoma in carefully selected patients. Our aim was to evaluate whether percutaneous endoscopic nephron-sparing operation was feasible for patients with renal cell carcinoma.Methods A total of 15 patients with renal pelvis carcinoma were treated with laser evaporation under percutaneous endoscopy between January 2015 and September 2019 ( group I ). Another 13 patients who received standard radical nephroureterectomy were recruited as the control group (group II). We recorded demographic data of the patients, the indication for surgery, tumor pathological grade, size and side of tumor, and the intraoperative and postoperative outcome, including the duration of surgery, length of hospital stay, and complication rate, as well as progression-free survival (PFS).Results In both groups, all of the patients received flexible ureteroscopy. In group I, 14 patients had transitional renal cell carcinoma (UCC), four had pathological grade I, nine had grade II, and one had hemangiopericytoma. In group II, all patients had UCC, five had pathological grade I, and eight had grade II. In group I, the mean operation time was 118 min (65–236 min), the mean blood loss was 110 ml (55–220 ml), and the mean hospital stay was 9 days (7–12 days). During follow-up, two patients died and two had recurrence; among them, one had systematic bone metastasis. The PFS rate was 66.7% (10/15). In group II, the mean operation time was 265 min (185–436 min), the mean blood loss was 133 ml (85–240 ml), and the mean hospital stay was 13 days (9–16 days). During the follow-up, two patients died and there was no local or systematic metastasis. The PFS rate was 84.6% (11/13). There was no significant difference in blood loss between the groups. However, the operation time and mean hospital stay were significantly shorter in group I compared with that in group II ( P < 0.05). But the PFS rate was significantly higher in group II than in group I (P < 0.05).Conclusions This study shows that laser evaporation under percutaneous endoscopy for renal pelvis carcinoma is a safe, effective, and technically feasible procedure for treating benign and malignant renal pelvis carcinoma.
Finite Element Analysis of Different Percutaneous Fixation Strategies Used for the Treatment of Tile C1.2 Pelvic Fracture
Authors: Xu changqing , Zhu wanbo , Liu lei , Yang jiazhao , Fang shiyuan
Published: July 2020

Objectives

We evaluated the biomechanical outcomes of 9 different percutaneous fixation strategies used for the fixation of Tile C1.2 pelvic fracture. This may help surgeons choose the optimal therapy for the unstable pelvic fracture.
Methods

Tile C1.2 pelvic fractures and implant models were constructed using finite element analysis (FEA) software. Models were assembled for different fracture fixation types. After meshing the models’ elements, we used Abaqus software to perform the FEA. Values of the von Mises Stress and model displacement were used to capture the mechanical factors.
Results

The FEA shows that under axial loading and external rotational loading of 500 N, the combination of an S1 screw and the Infix system provide strong stability, and that an increased number of screws to fix the anterior pelvic ring increased stability.
Conclusion

This study indicates that a 3-screw-Infix system on the healthy side, plus an S1 sacroiliac screw improves stability of the Tile C1.2 fracture.
Fetal double aortic arch: prenatal sonographic and postnatal computed tomography angiography features, associated abnormalities and clinical outcomes
Authors: Guo Qiao , Kong Yifan , Zeng Shi , Zhou Jiawei , Wang Xiaofang , Shang Quanliang , Zhou Jia , Yuan Hongxia , Wang Ling , Tong Lili , Yi Aijiao , Zhou Qichang
Published: July 2020

Background: Fetal double aortic arch (DAA) malformation is a rare congenital heart disease. There is a lack of large sample on comparative study of prenatal ultrasound diagnosis with postnatal computed tomography angiography (CTA) diagnosis, surgery, and autopsy results.Methods: A retrospective cohort study was carried out on cases of fetal DAA that underwent a comprehensive ultrasound examination and were seen during a six-year period at seven tertiary referral centers.Results: A total of 36 cases out of 40 prenatally diagnosed DAA fetuses were confirmed by postnatal diagnosis (fetal autopsy, CTA, and surgery). In this cohort of 36 confirmed cases, 24 (67%) were isolated anomalies, while 12 (33%) were associated with intracardiac or extracardiac anomalies, and 2 (6%) had a 22q11.2 chromosome deletion. There were 9 cases of pregnancy termination with a fetal autopsy. Among the remaining 27 live births, 16 (59%) were asymptomatic and 11 (41%) received surgical treatment due to tracheal or esophageal compression symptoms, all with satisfactory outcomes. Prenatal echocardiography showed that DAA was mainly characterized by a bifurcation of the ascending aorta into the right and left aortic arch and the formation of a complete O-shaped vascular ring around the trachea on the three-vessel tracheal view. A variant in the aortic arch branching pattern was found for the first time. The airway obstruction, branching pattern and atretic arch of DAA were clearly shown by postnatal CTA.Conclusions: Fetal DAA has unique features on prenatal echocardiography and postnatal CTA, and steps and tips for systematic prenatal examination are required. The clinical outcomes of isolated DAA are favorable, even if surgery is performed due to symptoms. Determining whether other malformations or chromosomal anomalies exist is crucial for prognosis evaluation and prenatal decision-making.
PlatCOVID: A Novel Web Tool to Analyze, Curate and Share COVID-19 Literature
Authors: Brandão Lucas André Cavalcanti , Agrelli Almerinda , Bernardo Lucas , Paparella Francesco , Moura Ronald , Crovella Sergio
Published: July 2020

BackgroundIn the attempt to face the COVID-19 pandemic, the global scientific community has been expending great efforts to produce useful and reliable data aiming to help patients, physicians and guiding public health policies. A huge amount of information is being released every week, making impossible for a single person (or even for a research group) to read everything and get constantly updated on the scientific literature concerning COVID-19 and its etiological agent, SARS-CoV-2. Therefore, we developed PlatCOVID (www.platcovid.com), a Web platform designed to analyze, cluster, classify and discuss COVID-19 literature available on LitCovid (NCBI). ResultsPlatCOVID has been created as a novel COVID-19 hub able to add features of text mining and syntax analyses methods, such as word and sentence atomization and tokenization, clusterization and classification. The main division of the literature comprehends five categories: 1) Diagnosis; 2) Epidemiology; 3) Clinical, Signs & Symptoms; 4) Transmission; and 5) Treatment & Prevention. Consequently, it is possible to reduce the amount of text to be read with minimal loss of information, identifying target subjects by mining as new insights arise, enhancing data analysis efficiency. PlatCOVID has been designed with central panels (Gene, Drug and Tissue panels) to easily gather and share with the scientific community important COVID-19 information.ConclusionsAlthough most of the text mining and syntax analysis is made by using automated computing processes, the final results must to be humanly curated. With this in mind, PlatCOVID allows researchers to be part of our effort to curate, analyze, discuss and rate each matter of interest (helpus.platcovid.com). We welcome user feedback for further enhancement.
Household knowledge, perceptions and practices of mosquito larval source management for malaria prevention and control in Mwanza district, Malawi: A cross-sectional study
Authors: Kamndaya Mphatso , Mfipa Dumisani , Lungu Kingsley
Published: July 2020

Background
Mosquito larval source management (LSM) is a key outdoor malaria vector control strategy in rural communities in sub-Saharan Africa. Knowledge of this strategy is important for optimal design and implementation of effective malaria control interventions in this region. This study assessed household knowledge, perceptions and practices of mosquito LSM methods (draining stagnant water, larviciding, clearing grass/bushes and clean environment).
Methods
A cross-sectional design was used whereby 479 households were selected using two-stage sampling in Mwanza district, Malawi. A household questionnaire was administered to the head of the house. Respondents were asked questions on knowledge, perceptions and practices of mosquito LSM methods. Multivariable logistic regression model was used to identify factors associated with high-level knowledge of mosquito LSM methods.
Results
Majority of the respondents (64.3%) had high-level knowledge of mosquito LSM methods. Specifically, 63.7% (200/314) had positive-perceptions about draining stagnant water whereas 95.3% (223/234) practiced clean environment for malaria control and 5.2% had knowledge about larviciding. Compared to respondents with primary education, those with secondary education were 3.04 times more likely to have high-level knowledge of mosquito LSM methods (AOR = 3.04, 95% CI 1.30–7.14), whereas those with no education were 0.40 times less likely to have high-level knowledge of mosquito LSM methods (AOR = 0.40, 95% CI 0.24–0.67). Respondents living in mudwalled households were 0.54 times less likely to have high-level knowledge of mosquito LSM methods as compared with those living in brickwalled households (AOR = 0.54, 95% CI 0.32–0.92).
Conclusions
Larviciding was the least mentioned method whereas positive-perceptions for larviciding and clearing grass/bushes were low. Targeted health promotion interventions may improve knowledge, perceptions and practices of mosquito LSM methods in communities.
Student Perspective Of Classroom And Distance Learning Method During Covid-19 Pandemic In The Undergraduate Dental Study Program
Authors: Amir Lisa , Tanti Ira , Maharani Diah Ayu , Wimardhani Yuniardini , Julia Vera , Sulijaya Benso , Puspitawati Ria
Published: July 2020

Background: The COVID-19 pandemic has become a global health issue and has had a major impact on education. Consequently, half way through the even semester of the academic year 2019/2020, learning methods were delivered through distance learning. This study aimed to evaluate the s tudent perspective of distance learning compared to the classroom learning in the undergraduate dentistry study program at the Faculty of Dentistry Universitas Indonesia. Methods: An online questionnaire was sent to dental students of Universitas Indonesia at the end of the semester. Three hundred and one undergraduate dental students participated in the study, with 83.4% response rate. The internal consistency reliability questionnaire was measured by Cronbach’s alpha. Logistic regression analyses were conducted to identify factors associated with the students’ preference towards distance learning. Results: Duration of study influenced student preference on distance learning (DL). Significantly higher number of first-year students preferred DL compared to their seniors (p<0.001). While neither gender nor Grade Point Average (GPA) score influenced student preference on DL. Students agreed that DL was suitable for lectures and examination while they preferred classroom learning (CL) for group discussion, as DL resulted in more difficult communication and gave less learning satisfaction. Only 44.5% students preferred DL over CL, although they agreed that DL gave a more efficient learning method (52.6%), it provided more time to study (87.9%) and to review study materials (87.3%). The Cronbach alpha of the questionnaire was 0.880. The logistic regression analysis showed that efficiency has the highest odds ratio in relation to preference towards distance learning. Challenges during distance learning included external factors such as unstable internet connection, extra financial burden for the internet quota and internal factors such as time management and difficulty to focus while learning online for a longer period of time. Conclusion: Despite some challenges, dental students could adapt to the new learning methods of full DL and the majorities agreed blended learning that combined classroom and distance learning can be implemented henceforth. This current COVID-19 pandemic, changes not only the utilization of technology in education but the pedagogy strategies in the future.
Optimization of membrane dispersion ethanol precipitation process with a set of temperature control improved equipment
Authors: Pan Jingjing , Tai Yanni , Qu Haibin , Gong Xingchu
Published: July 2020

Background
Ethanol precipitation is an important separation and purification process in the traditional Chinese medicine (TCM) industry. However, ethanol precipitation process suffers from loss of active ingredients, low batch-to-batch consistency of supernatant composition, and long standing time. These problems are mainly caused by low efficient equipment and imperfect control strategy.
Methods
In the present study, a membrane dispersion ethanol precipitation device which can achieve rapid cooling was developed for Astragali radix ethanol precipitation. Ethanol precipitation process was optimized according to Quality by design concept. To identify critical material attributes (CMAs), ten batches of Astragali radix was used to prepare concentrates. Definitive screening design was used to investigate the relationships among critical process parameters, CMAs, and process critical quality attributes (CQAs).
Results
Calycosin-7-O-β-D-glucoside content, the sucrose content, and the electrical conductivity were found to be CMAs after the correlation analysis and stepwise regression modelling. Quadratic models were developed and design space was calculated according to the probability of attaining process CQA standards. A material quality control strategy was proposed. High quality and low quality Astragali radix concentrates can be discriminated by the inequalities. Low quality Astragali radix concentrates should not be released for ethanol precipitation process directly. Verification experiment results indicated accurate models and reliable design space.
Conclusions
The temperature control method and control strategy in this study are effective and promising for ethanol precipitation process of other TCMs or foods.
The effect of surgical decompression on symptoms in peroneal nerve entrapment neuropathy
Authors: Ercan Serdar , Ataizi Zeki Serdar
Published: July 2020

Objective

CPN entrapment neuropathy is a form of lower extremity entrapment, most commonly seen at the level of the fibula head, often presenting with foot drop findings. We aimed to investigate whether decompressive surgical intervention contributes to neuropathy clinic.
Materials and methods

Patients who were admitted to our clinic with a preliminary diagnosis of peroneal entrapment neuropathy and underwent surgical intervention were included in the study. Preoperative and postoperative motor functions and pain were evaluated.
Results

Postoperative significant changes in pain and muscle strength scores were observed. A significant decrease was observed in the postoperative VAS score.
Conclusion

Surgical decompression is the right option for the recovery of motor function in the treatment of peroneal nerve entrapment neuropathy.