bluuebunny/crossref_metadata_2025 huggingface dataset:
Adversarial unsupervised domain adaptation based on generative adversarial network for stock trend forecasting
Authors: Wei Qiheng , Dai Qun
Published: August 2023

Stock trend forecasting, which refers to the prediction of the rise and fall of the next day’s stock price, is a promising research field in financial time series forecasting, with a large quantity of well-performing algorithms and models being proposed. However, most of the studies focus on trend prediction for stocks with a large number of samples, while the trend prediction problem of newly listed stocks with only a small number of samples is neglected. In this work, we innovatively design a solution to the Small Sample Size (SSS) trend prediction problem of newly listed stocks. Traditional Machine Learning (ML) and Deep Learning (DL) techniques are based on the assumption that the available labeled samples are substantial, which is invalid for SSS trend prediction of newly listed stocks. In order to break out of this dilemma, we propose a novel Adversarial Unsupervised Domain Adaptation Network (AUDA-Net), based on Generative Adversarial Network (GAN), ad hoc for SSS stock trend forecasting. Different from the traditional domain adaptation algorithms, we employ a GAN model, which is trained on basis of the target stock dataset, to effectively solve the absence problem of available samples. Notably, AUDA-Net can reasonably and successfully transfer the knowledge learned from the source stock dataset to the newly listed stocks with only a few samples. The stock trend forecasting performance of our proposed AUDA-Net model has been verified through extensive experiments conducted on several real stock datasets of the U.S. stock market. Using stock trend forecasting as a case study, we show that the SSS forecasting results produced by AUDA-Net are favorably comparable to the state-of-the-art.
Capturing Measures That Matter: The Potential Value of Digital Measures of Physical Behavior for Alzheimer’s Disease Drug Development
Authors: Bachman Shelby L. , Blankenship Jennifer M. , Busa Michael , Serviente Corinna , Lyden Kate , Clay Ieuan
Published: August 2023

Alzheimer’s disease (AD) is a devastating neurodegenerative disease and the primary cause of dementia worldwide. Despite the magnitude of AD’s impact on patients, caregivers, and society, nearly all AD clinical trials fail. A potential contributor to this high rate of failure is that established clinical outcome assessments fail to capture subtle clinical changes, entail high burden for patients and their caregivers, and ineffectively address the aspects of health deemed important by patients and their caregivers. AD progression is associated with widespread changes in physical behavior that have impacts on the ability to function independently, which is a meaningful aspect of health for patients with AD and important for diagnosis. However, established assessments of functional independence remain underutilized in AD clinical trials and are limited by subjective biases and ceiling effects. Digital measures of real-world physical behavior assessed passively, continuously, and remotely using digital health technologies have the potential to address some of these limitations and to capture aspects of functional independence in patients with AD. In particular, measures of real-world gait, physical activity, and life-space mobility captured with wearable sensors may offer value. Additional research is needed to understand the validity, feasibility, and acceptability of these measures in AD clinical research.
Different Trajectories of Apathy and Depression Among Subjective Cognitive Impairment Individuals with or without Conversion to Dementia: Results from the Memento Cohort in France
Authors: Bogdan Anamaria ,   the Memento Group, Fabre Roxane , Desmidt Thomas , Golebiowski Jérôme , Topin Jérémie , Bethus Ingrid , Hanon Olivier , Boutoleau-Bretonniere Claire , Wagemann Nathalie , Annweiler Cédric , Ousset Pierre-Jean , Godefroy Olivier , Rouch Isabelle , Paccalin Marc , Sukhorukova Maryana , Gabelle Audrey , Robert Gabriel , David Renaud
Published: August 2023

Background: Apathy and depression are two early behavioral symptoms in Alzheimer’s disease (AD) and related disorders that often occur prior to the onset of cognitive decline and memory disturbances. Both have been associated with an increased risk of conversion to dementia, with a distinct neuropathology. Objective: The assessment of the trajectories of apathy and depression and their independent impact on dementia conversion. Methods: Apathy and Depression were measured using the Neuropsychiatric Inventory for caregiver (NPI) and clinician (NPI-C), among the nondemented individuals reporting subjective cognitive decline (SCD) at baseline. They were followed up over a 60-month period. Some converted to dementia, according to the methodology carried out by the French Memento Cohort. Results: Among individuals with SCD (n = 2,323), the levels of apathy and depression were low and did not evolve significantly over the 60-month period, despite a trend in apathy increasing as of month 24. Regarding SCD individuals who converted to dementia within the 60-month period (n = 27), the prevalence of depression remained globally steady, while the levels of apathy increased over time. Conclusion: Apathy and depression have different trajectories among individuals with SCD and apathy alone is more likely—compared to depression—to be associated with conversion to dementia.
Vascular Cognitive Impairment: A Little Bit of Good News for Women or Bad News for Men?
Authors: Volgman Annabelle Santos , Engelstein Erica , Aggarwal Neelum T.
Published: August 2023

In a recent issue of the Journal of Alzheimer’s Disease, Zinman et al. investigated the role of sex in the risk of cognitive impairment in 5,969 patients with a stroke or transient ischemic attacks. Using a short validated clinical screening tool, they noted that men had a 34% higher risk of screening positive for post-stroke cognitive impairment after adjusting for age, education, and stroke severity compared to women. This study highlights that more large, prospective, and multicenter studies are needed to evaluate sex-specific changes after a stroke since sex differences exist in many aspects of stroke presentation and management.
Hemorheological changes in arterial hypertension in persons with and without COVID-19
Authors: Muravyov A.V. , Priezzhev A.V. , Tikhomirova I.A. , Lugovtsov A.E. , Mikhailov P.V.
Published: August 2023

BACKGROUND:

Vascular resistance, and therefore blood pressure (BP), depends on vascular and rheological factors. Microrheological characteristics of red blood cells (RBCs) can affect blood viscosity (BV) and thus be included in the pathogenesis of increased blood pressure in arterial hypertension (AH). Signaling molecules such as gasotransmitters (NO, CO and H2S) regulate vascular tone and RBC microrheological characteristics and thus affect blood pressure and tissue perfusion.

OBJECTIVE:

It was evaluated the changes in the macro- and microrheological characteristics of blood and red blood cells (RBCs) under arterial hypertension in persons with and without COVID-19, as well as the protective effect of NO and H2S donors on the RBC microrheological properties.

METHODS:

Hemorheological profile parameters were recorded in group 1 individuals ( n = 18, 9 women and 9 men) without a history of COVID-19; group 2 ( n = 16; 11 females and 5 males), hypertensive patients who had COVID-19. As a control, there was a group of healthy individuals (group 3 n = 22). In experiments with red blood cells (RBCs) and their recovered ghosts (filled with an isotonic solution of known viscosity), deformability (RBCD) and aggregation (RBCA) were recorded after incubation of cells with sodium nitroprusside (SNP, 100μM) and sodium hydrosulfide (NaHS, 100μM).

RESULTS:

In patients with AH in both groups, the main parameters of the hemorheological profile were negatively changed, including a decrease in RBCD and an increase in BV, plasma viscosity (PV) and RBCA. SNP and NaHS significantly increased deformability and reduced their aggregation ( p < 0.01). However, in healthy individuals, microrheological responses to GT donors (100μM) were more pronounced than in patients with AH, especially in the AH+COVID-19 group ( p < 0.05).

CONCLUSION:

Both gasotransmitter donors (NO and H2S) have a positive effect on the RBC microrheological characteristics in healthy and sick individuals. However in hypertensive patients, especially those who had COVID-19, microrheological responses to GT donors were significantly lower. Therefore, on the model of red cell microrheological responses, as on a test object, it is possible to determine the decrease in the sensitivity of cells and tissues to the regulatory action of gasotransmitters.
Prediction of the belt drive contamination status based on vibration analysis and artificial neural network
Authors: Baqer Ihsan A. , Jaber Alaa Abdulhady , Soud Wafa A.
Published: August 2023

Belt drive contamination is considered one of the most common failure modes that could be developed in the belts due to harsh operation conditions, high humidity, and sunlight exposure, reducing the belt’s performance. If the belt failure has not been detected early, a sudden shutdown may happen, producing safety and economic consequences. However, most maintenance personnel use their senses of sight, hearing, smell, and touch to identify the cause of the problem while diagnosing a belt drive condition. Hence, this research involves developing an intelligent contamination status detection system based on vibration signal analysis for a pulley-belt rotating system. Time-domain signal analysis was employed to extract some suggestive features such as the root mean square, kurtosis, and skewness from the vibration data. An artificial neural network (ANN) model was built to detect the simulated different operating conditions. The vibration data was gathered with the help of two MEMS accelerometers (ADXL335) interfaced with an NI USB-6009 data acquisition device. A signal capture, analysis, and feature extraction system was developed using Matlab Simulink. The simulated operating conditions include clean, wet, and powder-contaminated belts. The results showed that the designed system could identify the pulley-belt operation conditions with 100% overall accuracy.
A novel frequency-range analysis (FRA) method for determining critical words among English high-stakes tests
Authors: Chen Liang-Ching , Chang Kuei-Hu
Published: August 2023

Within the new era of artificial intelligence (AI), education industry should develop in the direction of intelligence and digitalization. For evaluating learners’ academic performances, English high-stakes test is not only a mere means for measuring what English as a Foreign Language (EFL) stakeholders know or do not know but also likely to bring life-changing consequences. Hence, effective test preparation for English high-stakes test is crucial for those who futures depend on attaining a particular score. However, traditional corpus-based approaches cannot simultaneously take words’ frequency and range variables into consideration when evaluating their importance level, which makes the word sorting results inaccurate. Thus, to effectively and accurately extract critical words among English high-stakes test for enhancing EFL stakeholders’ test performance, this paper integrates a corpus-based approach and a revised Importance-Performance Analysis (IPA) method to develop a novel frequency-range analysis (FRA) method. Taiwan College Entrance Exam of English Subject (TCEEES) from the year of 2001 to 2022 are adopted as an empirical case of English high stake test and the target corpus for verification. Results indicate that the critical words evaluated by FRA method are concentrated on Quadrant I including 1,576 word types that account for over 60% running words of TCEEES corpus. After compared with the three traditional corpus-based approaches and the Term Frequency-Inverse Document Frequency (TF-IDF) method, the significant contributions include: (1) the FRA method can use a machine-based function words elimination technique to enhance the efficiency; (2) the FRA method can simultaneously take words’ frequency and range variables into consideration; (3) the FRA method can effectively conduct cluster analysis by categorizing the words into the four quadrants that based on their relative importance level. The results will give EFL stakeholders a clearer picture of how to allocate their learning time and education resources into critical words acquisition.
Auditing of hadoop log file for dynamic detection of threats using H-ISSM-MIM and convolutional neural network
Authors: Suganya S. , Selvamuthukumaran S.
Published: August 2023

Hadoop is a big data processing system that enables the distributed processing of massive data sets across multiple computers using straightforward programming techniques. Hadoop has been extensively investigated in many attacks as a result of its growing significance in industry. A company may learn about the actions of invaders as well as the weaknesses of the Hadoop cluster by examining a significant quantity of data from the log file. In a Big Data setting, the goal of the paper is to generate an analytical classification for intrusion detection. In this study, Hadoop log files were examined based on assaults that were recorded in the log files. Prior to analysis, the log data is cleaned and improved using a Hadoop preprocessing tool. For feature extraction, the hybrid Improved Sparrow Search Algorithm with Mutual Information Maximization (H-ISSA-MIM). Then the CNN (Convolutional Neural Network) classifier will detect the intrusions. The implementation is performed using the MATLAB 2020a software. The performance metrics like accuracy, precision, F-score, recall, specificity, FPR, FNR are calculated for the proposed methodology and it is compared with the existing techniques like Decision Tree (DT), Principal Components Analysis (PCA)- K means, Long Short Time Memory (LSTM). The maximum value of accuracy finds out in the proposed method 98% .
The perils of pre-filling: Lessons from the UK’s Annual Survey of Hours and Earning microdata
Authors: Whittard Damian , Ritchie Felix , Phan Van , Bryson Alex , Forth John , Stokes Lucy , Singleton Carl
Published: August 2023

The role of the National Statistical Institution (NSI) is changing, with many now making microdata available to researchers through secure research environments This provides NSIs with an opportunity to benefit from the methodological input from researchers who challenge the data in new ways This article uses the United Kingdom’s Annual Survey of Hours and Earnings (ASHE) to illustrate the point We study whether the use of prefilled forms in ASHE may create inaccurate values in one of the key fields, workplace location, despite there being no direct evidence of it in the data supplied to researchers. We link surveys to examine the hypothesis that employees working for multi-site employers making an ASHE survey submission are more likely to have their work location incorrectly recorded as the respondent fails to correct the work location variable that has been pre-filled. In the short-term, suggestions are made to improve the quality of ASHE microdata, while longer-term we suggest that the burden of collecting additional data could be offset through greater use of electronic data capture. More generally, in a time when statistical budgets are under pressure, this study encourages NSIs to make greater use of the microdata research community to help inform statistical developments.
The risk factors for coagulation disorder of chimeric antigen receptor-T cell therapy in patients with hematological tumors: A systematic review and meta-analysis
Authors: Xia Yunqing , Tang Liang , Hu Yu
Published: August 2023

BACKGROUND: Currently, the frequency of coagulation dysfunction associated with chimeric antigen receptor-T cell (Car-T) therapy cannot yet be determined. OBJECTIVE: We performed a systematic review and meta-analysis to examine the prevalence of abnormal laboratory tests related to coagulation disorders in patients receiving Car-T therapy and provide a reference for future risk assessment mechanisms. METHODS: We searched PubMed, Embase, and Web of Science for relevant studies and evaluated their quality using the methodology index of non-random research (MINORS). 2672 quotations were retrieved via systematic searches. After screening of titles, abstracts and full-text, 45 trials involving 2541 patients were ultimately included. 41 studies reported the incidence of thrombocytopenia, 8 studies reported the rate of low fibrin, 4 trials reported the rate of APTT or PT abnormalities and only 3 trials reported the incidence of venous thromboembolism (VTE). We performed a quantitative meta-analysis to explore the incidence of thrombocytopenia following Car-T treatment. The incidence of hypofibrinogenemia, VTE, and abnormal APTT or PT was only qualitatively assessed, as fewer reports were included in this study. RESULTS: The overall incidence of thrombocytopenia associated with Car-T therapy was 45.8% (95%[CI], 0.384–0.533). The highest rates of thrombocytopenia occurred in patients with multiple myeloma (60.1%, 95%[CI], 0.507–0.688) and aged between 18 to 60 (50%, 95%[CI], 0.367–0.633). There was greater prevalence of thrombocytopenia in BCMA-Car-T therapy of 58.7% (95%[CI], 0.482–0.685). Thrombocytopenia occurred most frequently in Car-T patients treated with a dosage of 1 × 105–1 × 106 cell/kg, at a rate of 66.2% (95%[CI], 0.561–0.749). CONCLUSION: Overall, 45.8 percent of patients receiving Car-T treatment suffered from thrombocytopenia. Multiple myeloma patients, ages between 18–60, a dose of 1 × 105–1 × 106 cell/kg and BCMA-Car-T therapy are all considered high-risk factors.
Transcriptomic sequencing analysis of key long noncoding RNAs and mRNAs expression profiles in postoperative recurrence of hepatocellular carcinoma
Authors: Yao Xiaohui , Liu Shan , Xia Huan , Li Hanhan , Wang Zhijie , Su Le , Guo Wei , Chen Hanrui
Published: August 2023

BACKGROUND: Recurrence is the main cause of death in hepatocellular carcinoma (HCC) patients after liver resection. OBJECTIVE: The long non-coding RNAs (lncRNAs) have been reported participated in progression and prognosis of HCC, however, the vital role of lncRNA in postoperative recurrence of HCC has rarely been systematically identified. METHODS: RNA-sequencing (RNA-seq) was performed between orthotopic model of HCC and hepatoma postoperative recurrent model to comprehensively analyze the integrated transcriptome expression profiles of lncRNA and mRNA. Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) was then conducted to quantify the expression levels of DElncRNAs and their target mRNAs. RESULTS: In our study, 211 lncRNAs (P-value < 0.05) and 1125 mRNAs (P-adjust < 0.05) were significantly differentially expressed (DE) between two groups. Moreover, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that DElncRNAs and DEmRNAs were mainly enriched in lipid metabolism, including Arachidonic acid metabolism, PPAR signaling pathway, Steroid hormone biosynthesis, Linoleic acid metabolism, Inflammatory mediator regulation of TRP channels, and Fatty acid degradation. Furthermore, we constructed lncRNA-mRNA interaction networks and protein-protein interaction (PPI) network, and verified by qRT-PCR, suggesting that increased DEIncRNAs (XLOC_063499 and XLOC_042016) may prevent HCC recurrence after surgery by upregulating on targeted cytochrome P450 (CYP) family genes in the lipid metabolism pathway, such as cyp3a16, cyp3a44, cyp2c39, cyp2c40 and cyp2c68. CONCLUSION: Overall, Our findings provided new insights for further investigation of biological function in lncRNA related HCC recurrence.
Development and clinical empirical validation of the chronic critical illness prognosis prediction model
Authors: Zhao Li , Xu Wen-Kui , Wang Ying , Lu Wei-Yan , Wu Yong , Hu Rong
Published: August 2023

BACKGROUND: The evolution of critical care medicine and nursing has aided and enabled the rescue of a large number of patients from numerous life-threatening diseases. However, in many cases, patient health may not be quickly restored, and the long-term prognosis may not be optimistic. OBJECTIVES: In this study, we aimed to develop and validate a prediction model for accurate, precise, and objective identification of the severity of chronic critical illness (CCI) in patients. METHODS: We used a retrospective case-control and prospective cohort study with no interventions. Patients diagnosed with CCI admitted to the ICU of a large metropolitan public hospital were selected. In the case-control study, 344 patients (case: 172; control:172) were enrolled to develop the prognosis prediction model of chronic critical illness (PPCCI Model); 88 patients (case:44; control: 44) in a prospective cohort study, served as the validation cohort. The discrimination of the model was measured using the area under the curve (AUC) of the receiver operating characteristic curve (ROC). RESULTS: Age, prolonged mechanical ventilation (PMV), sepsis or other severe infections, Glasgow Coma Scale (GCS), mean artery pressure (MAP), heart rate (HR), respiratory rate (RR), oxygenation index (OI), and active bleeding were the nine predictors included in the model. In both cohorts, the PPCCI model outperformed the Acute Physiology And Chronic Health Evaluation II (APACHE II), Modified Early Warning Score (MEWS), and Sequential Organ Failure Assessment (SOFA) in identifying deceased patients with CCI (development cohort: AUC, 0.934; 95%CI, 0.908–0.960; validation cohort: AUC, 0.965; 95% CI, 0.931–0.999). CONCLUSION: The PPCCI model can provide ICU medical staff with a standardized measurement tool for assessing the condition of patients with CCI, enabling them to allocate ward monitoring resources rationally and communicate with family members.
Identification and analysis of genes associated with the severity and prognosis of sepsis
Authors: Hao Jinxiang , Liang Lirong , Ma Yongduo , Xu Meisha , Li Qiuxiang
Published: August 2023

BACKGROUND: With rapid progression, severe illness and high fatality rate, sepsis has become an acute and critical condition that seriously threatens human life and health. OBJECTIVE: To detect miR-210 and miR-494 expression in patients with sepsis and their relationship with severity and prognosis. METHODS: A total of 165 sepsis patients participated, including 105 patients with septic non-shock and 60 patients with septic shock. 53 sepsis patients died in 28 days, and 112 patients survived. The clinical information of all sepsis patients was retrospectively searched and reviewed. Based on the status of 28-day survival, they were categorized into survival group and death group. The expression levels in each group were compared on the first, third and seventh day. The ROC curve was applied to know the expression level of plasma miR-210 and miR-494 to predict the death. RESULTS: The two miRNAs expression of the septic shock group were significantly higher than that in sepsis non-shock group on the first, third and seventh day (all were P< 0.05). The ROC curve found that the AUC combined to predict the death on the third day was the largest, which was 0.925 (95%CI: 0.864–0.983). The sensitivity and specificity were 94.6% and 86.3%, respectively. CONCLUSION: The increased expression levels of plasma miR-210 and miR-494 are closely relevant to the severity and prognosis of sepsis patients. Combining the two items on the third day can predict the death of sepsis patients.
Differentially expressed miR-4310 functions as a tumor suppressor in colorectal cancer
Authors: Jiang Ziwei , Yi Peiling , You Jinping , Cai Erwei
Published: August 2023

BACKGROUND: Colorectal cancer (CRC) is a digestive tract malignancy microRNAs (miRNAs) have attracted much attention as biomarkers in tumor studies. OBJECTIVE: This work focused on the predictive potential and mechanism of miR-4310 in CRC. METHODS: The miRNA expression profile sets were obtained from the Gene Expression Omnibus (GEO) database, and the appropriate miRNA was screened by GEO2R. The CRC tissues and control tissues of 88 patients with CRC were collected, and the expression of miR-4310 was detected by quantitative real-time PCR, and the efficacy of miR-4310 in diagnosing CRC was evaluated by the receiver operating characteristic curve (ROC). The effects of miR-4310 on the proliferation, migration, and invasion of CRC cells were explored by Cell Counting Kit-8 (CCK-8) and Transwell experiments. Predicting the potential binding sites of miR-4310 and Runt-related transcription factor 1 (RUNX1) by four predictive websites. The relationship between miR-4310 and RUNX1 was confirmed by a double luciferase reporter gene experiment. RESULTS: The bioinformatics analysis found that miR-4310 was differentially expressed in CRC tissues and this finding was certified by the expression of miR-4310 in CRC tissues of collected patients and cultured CRC cell lines. The expression of miR-4310 had a predictive possibility for CRC patients. MiR-4310/RUNX1 pathway had effects on CRC viability, migration, and invasion. CONCLUSION: MiR-4310 had the potential to be a biomarker for early screening of CRC. MiR-4310 and RUNX1 participated in the regulation of CRC cells.
Forecasting supercritical behavior of drill strings in horizontal wells
Authors: Gaidaichuk Viktor , Levkivska Lyudmyla , Lazareva Maryna
Published: August 2023

The determining factor in the current changes in the world energy balance and its structure, as well as the global development of the oil and gas industry, is currently the technological factor. As a result, fundamentally new categories of horizontal and inclined wells appeared and developed. They give a multiple increase in flow rates, as they increase the production area many times over. They are used in the development of offshore projects, in swampy and very difficult areas, to increase oil recovery, restoration of inactive wells.
New technologies based on the method of horizontal drilling have revolutionized the practice and theory of world oil production, as they have allowed the destruction of offshore oil and gas fields without the construction of expensive offshore foundations and platforms.
When drilling horizontal wells, as a rule, the main cause of emergencies is the loss of stability of the drill string, its bifurcation protrusion and the maximum frictional interaction with the well wall. The issues of theoretical modeling of the phenomenon of unstable protrusion of columns are associated with significant difficulties, the main of which is due to the need to set the Sturm-Liouville boundary value problem on a large length of drill string. Because for deep wells, the drill string becomes geometrically similar to a human hair, many traditional mathematical methods used to integrate solving equations become poorly convergent in these cases.
Based on the theory of curvilinear flexible rods, the problem of theoretical modeling of supercritical states of drill strings taking into account their contact interaction with the walls of oil and gas wells is set. Analytical solutions of the problem are constructed, which determine the critical values of external tensile or compressive longitudinal force and torque at a given difference in the diameters of the cavity and the drill string, the zones of supercritical states of drill strings are established.
Methodological Foundations Protective Structures Development for Shielding Electromagnetic and Acoustic Fields
Authors: Glyva Valentyn , Zaporozhets Oleksandr , Levchenko Larysa , Burdeina Nataliya , Nazarenko Vasyl'
Published: August 2023

In many cases the simultaneous protection against electromagnetic and acoustic fields of wide frequency ranges is required. The complexity of such a task lies in the impossibility of significantly reducing low-frequency sound levels with traditional sound-absorbing materials, as well as the different requirements for materials that shield low-frequency and high-frequency electromagnetic fields. It is proposed to solve this problem by creating a two-layer structure, the front surface of which is solid, and the inner surface is perforated. The front panel can be made of non-conductive material. It is a variant of the Bekeshi panel and is mainly intended to reduce the level of low-frequency sound of a certain frequency with high amplitude. The perforation of the internal (metal) panel is chosen based on the need to provide shielding of electromagnetic and acoustic fields of certain frequencies or frequency bands. A calculator is provided for calculating the required panel parameters (linear dimensions, thickness, hole diameters, their number per unit of surface area). It is advisable to fill the space between the panels with a sound-absorbing material, for example, granulated polystyrene. It provides sound absorption of medium and high frequencies and makes the design broadband. The use of ferromagnetic material of the inner panel provides protection against the magnetic component of the ultra-low frequency electromagnetic field (mainly industrial). The perforation of the panel is calculated based on the waveguide theory of high-frequency electromagnetic waves. The results of tests of the effectiveness of facing metal-polymer material in the form of tiles are presented. The performance of the material is satisfactory for most industrial and domestic conditions. Determination of the mechanical properties of the material (Young's modulus, shear modulus and Poisson's ratio) showed that it is not inferior to known materials even with a large content of shielding substance. In order to rationalize the design of the structure, a priority factor and frequency (frequency band) is selected on the basis of live measurements of the electromagnetic and acoustic spectra. It is shown that the calculations have large volumes, and the solution of two-factor optimization problems is not always possible. Appropriate creation of application software to simplify the process of designing protective structures and rationalizing panel parameters based on the principles of reasonable sufficiency.
Educational Responses to Artificial Intelligence (AI) Applications: Problems and Promise
Authors: Hyland Terry
Published: August 2023

The recent appearance of Artificial Intelligence (AI) applications such as Google’s Bard tool and OpenAI’s ChatGPT series has brought forth a flurry of reactions from both academic and popular commentators ranging from doom-laden pessimism to futuristic hyperbolic optimism. Both ends of this spectrum are revealed in the educational literature with the sharp contrast between critical accounts predicting the decline of academic standards and those welcoming the new applications as a means of enhancing teaching and learning. In the attempt to steer a middle way between these extremes, this article examines the merits and demerits of AI applications in education alongside the suggestion of possibilities for working with the new tools in a productive manner. In relation to ethical considerations raised by the recent developments, it is suggested that AI applications are best conceptualised as powerful entities – perhaps ideally regarded as non-human persons – which need to be utilised pragmatically and regulated ethically in partnership with humans in the best interests of all of us. Such a partnership model will be especially important to learners and teachers who are charged with making sense of a rapidly changing educational environment.
First Days after Death - A Jungian Comparison between the Beliefs of the Serbian Orthodox Church and the Post-mortem Experiences in the Tibetan Bardo Plan
Authors: Favre Dragana
Published: August 2023

This study examines the psychological aspects of the Bardo Thodol according to C.G. Jung and its relationship with Serbian Orthodox Christianity. Through a comparison of Jung's work "The Seven Sermons to the Dead" (published 12 years before his encounter with Buddhism) and "The Tibetan Book of the Dead," the researcher identifies similarities between these texts, the Bardo Thodol and the writings of the orthodox Church (with an accent on the Serbian Orthodox Church) These similarities include the significance of the soul after death, salvation symbolized by a luminous element, and the presence of an initiator guiding the soul towards salvation (reminiscent of the Orthodox belief in angels). Additionally, the interval between the moment of death and deliverance, present in both traditions, is highlighted.

Jung's postscript to the translation of "The Tibetan Book of the Dead" provides valuable insights into the psychological aspect of the book and the varying concept of the soul in Eastern and Western literature. He emphasizes that metaphysical assertions are expressions of the soul and, hence, psychological in nature. Jung describes the Bardo Thodol as a process of initiation aimed at restoring the divine nature of the soul, lost through birth.

The Bardo Thodol is deeply rooted in the archetypal representations of the unconscious. Jung's concept of archetypes as universal and hereditary psychic structures helps to understand the connection between the Bardo Thodol and the collective unconscious. Furthermore, the journey through the Bardo of Reality can be seen as a representation of the process of individuation, seeking to achieve wholeness and completeness.

Drawing parallels between Orthodox Christian mythology (mitarstva) and the Bardo of Reality, the researcher observes numerous similarities. This raises the question of whether mitarstva, with its well-organized structure involving demons, angels, repentance, and the 40-day journey of the soul after death, represents archetypal representations translating the layers of the collective unconscious in a Christian-pagan population.

Therefore, this study sheds light on the intriguing similarities between the Bardo Thodol and Serbian Orthodox Christianity from a psychological perspective, deepening our understanding of the complex interplay between ancient religious traditions and the universal elements of the unconscious mind.
Electron Spin Topology in Excited States and Fractional Spin Effect
Authors: Gao Ju , Shen Fang
Published: August 2023

The wave nature of the electron spin is shown by a multi-vortex current density topology in the excited states that is holographic in nature. When the wave spin interacts with a magnetic field smaller in size than the wave itself, fractional spin effect can be observed. The anomalous Zeeman splitting is shown to have a finer structure determined by the geometric factors and quantum numbers of the states.
Pengenalan Bahasa Inggris Sehari-hari Menggunakan Media Props Gambar di SD Negeri Sawangan 5
Authors: Nisaa Inayah Zukhruftun
Published: August 2023

Pengabdian ini merupakan salah satu kegiatan yang dilaksanakan oleh para mahasiswa dimana kegiatan tersebut memiliki tujuan untuk membantu masyarakat, yang pada kesempatan ini ditujukan kepada anak-anak anggota pramuka SD NegeriI Sawangan 5 untuk mengatasi kendala pembelajaran bahasa Inggris. Diharapkan peserta kegiatan menjadi lebih mudah untuk menyerap materi pembelajaran. Selain mengatasi kendala pembelajaran, kelompok ini juga bertujuan untuk memberikan materi yang bisa membantu peserta didik untuk lebih mengenal dan lebih familiar terhadap bahasa Inggris melalui pengenalan bahasa Inggris dasar yaitu berupa greeting, spelling dan daily conversation. Dengan metode pembelajaran props gambar, peserta didik akan lebih mudah mengenal kosakata baru, lebih nyaman dan senang dalam proses pembelajaran karena Sadiman (1996) berpendapat bahwa media yang paling umum di pakai untuk mengajar adalah media gambar, karena media gambar memiliki bahasan tersendiri, yang umum yang dapat dimengerti dan dinikmati dimana saja. Oleh karena itu, dengan media ini diharapkan peserta didik mampu menangkap dan menyerap dengan cepat materi yang disampaikan dan memberikan kesan sehingga peserta didik akan mengingat selalu tentang apa yang telah di pelajari. Kegiatan pembelajaran ini di lakukan secara luring atau tatap muka namun tetap mengikuti seluruh protokol kesehatan yang berlaku.
Dissecção da Axila no Tratamento do Câncer de Mama
Authors: Faria Sérgio Luis , Schlupp Werner R. , Cunha Ludmila S. Medina da , Chiminazzo Jr Honôrio , Oliveira Filho Juvenal A. de , Cunha Fernando Medina da
Published: August 2023

A dissecção da axila no tratamento do câncer da mama tem sido questionada quanto aos seus objetivos. No passado próximo a intenção era curativa: presentemente tem sido indicada principalmente para oferecer informação de extensão da doença (comprometimento de linfonodos por tumor) e tratamentos complementares, principalmente a quimioterapia adjuvante. Apenas alguns subgrupos de mulheres têm-se beneficiado realmente da quimioterapia adjuvante: as pré-meno-pausadas com linfonodos axilares comprometidos com tumor. Uma vez decidida a dissecção axilar, ainda resta a questão de saber se deve ser radical, ou limitada a níveis I e II (até músculo peitoral menor). Muitos centros importantes de câncer indicam a dissecção limitada da axila, que em média retira cerca de 10 linfonodos, alegando que desta forma não há risco de edema importante do braço e conseguem boa informação prognóstica e bom controle tumoral da axila. Aqueles que indicam a dissecção radical alegam que esta é a única forma de se obter informação real da situação axilar. Algumas pacientes podem ter linfonodos livres de tumor na parte baixa da axila, mas com tumor no ápice axilar ("skip metastasis") e a única forma de descobri-lo seria através da dissecção radical. Como a dissecção radical da axila pode causar edema do braço, é importante questionara real indicação da mesma. Pacientes em pós-menopausa e com axila clinicamente negativa talvez pudessem ter a alternativa de não dissecara axila de forma radical (e com isso não correr o risco de edema do braço), sem aumentara chance de falha de tratamento. O presente artigo discute o problema da dissecção da axila no tratamento do câncer da mama e mostra dados de 148 pacientes que fizeram tratamento conservador no Centro de Oncologia Campinas, metade das quais sem dissecção da axila.
Leiomiossarcoma Renal. Relato de caso com estudo imuno-histoquímico
Authors: Schmitt Fernando Carlos de L. , Cechella Marilia Santos , Daudt Carlos , Deboni Luciane Mônica , Bacchi Carlos Eduardo
Published: August 2023

Um caso raro de leiomiossarcoma renal é descrito. A caracterização histopatológica do material estudado, além das técnicas rotineiras, foi realizada com a técnica imuno-histoquímica associada a anticorpos monoclonais, definindo a neoplasia como de origem muscular. Uma breve discussão sobre a histogênese é apresentada.
Controversies Involving the Systemic Treatment for Metastatic Prostatic Cancer
Authors: Eisenberger Mario
Published: August 2023

In the United States, 1987 estimates of cancer incidence by site indicate that prostatic cancer is equal to lung cancer as the first in incidence in adult males. Over 90,000 new cases are diagnosed and between 25-30,000 patients die of this disease each year. While early prostatic cancer is a surgically curable disease, the majority of patients present with widely metastatic cancer, where the main objective of treatment is palliation.
Tratamento do Câncer do Colo do útero Estádio III com Adriamicina, Bleomicina e Cispiatinum (ABC) Neo-adjuvante, Histerectomia Radical Modificada e ABC Adjuvante
Authors: Valle José Carlos do , Ribeiro Celso Werneck , Rezende Magda Cortez , Figueiredo Euridice , Chu Cláudio
Published: August 2023

Quarenta e oito pacientes com carcinoma do colo do útero estádio III A e B foram tratadas com a associação de adriamicina (ADE), bleomicina (BLEO) e cisplatinum (CDDP), três a cinco ciclos neo-adjuvante, seguidos de histerectomia radical modificada e seis ciclos de ABC adjuvante. Quarenta doentes foram consideradas avaliáveis. Os primeiros 17 casos receberam ADR 50mg/m2, BLEO 10mg/d x 5 e CDDP 100mg/m2administrados no dia 1 e repetidos de 21/21 dias (ABC DA). A toxicidade neste grupo foi considerada inaceitável, com dois óbitos, sendo reduzidas as doses de CDDP e BLEO, respectivamente, 50mg/m2 e 6mg/d x 5 (ABD DB) nas 23 seguintes. Das 17 tratadas com o ABC DA, 12(70%) foram elegíveis para a cirurgia e o exame da peça revelou resposta completa (RC) em dois (11%) e resposta parcial (RP) em 10(59%). Das 23 tratadas com ABC DB, 16 (69%) foram operadas com RC confirmada em três (13%) e RP em 13 (56%). Após 38 meses, no grupo ABC DA, duas (12%) estão sem evidência de doença, quatro (23%) estão vivas com recorrência, sete (41%) morreram pela neoplasia, duas (12%) morreram por toxicidade (cardíaca e pulmonar), uma (5%) morreu de causa desconhecida e uma (5%) foi perdida do seguimento. No grupo ABC DB, em 36 meses, nove (39%) estão sem evidência de doença, sete (30%) estão vivas com recorrência, cinco (22%) morreram pela neoplasia e duas (9%) foram perdidas do seguimento. A sobrevida média estimada pelo método de Kaplan-Meier do grupo ABC DA é de 29% e do controle histórico de 102 pacientes tratadas pela radioterapia no mesmo período é de 52% (p < 0,01) e no ABC DB 63% (p <0,70 N.S.). Os resultados do grupo ABC DB, em 36 meses, analisados nas tabelas de vida e comparados com os controles demonstram resultados similares, porém, com melhor qualidade de sobrevida para as tratadas pelo ABC DB. O ABC DA por sua toxicidade não é recomendado. Das 28 que se submeteram à histerectomia radical modificada, 24 completaram pelo menos três ciclos adjuvantes do ABC e decorridos 38 meses, 20 das operadas estão vivas (71 %) comparado com 52% do grupo da RT (p = 0,004). O presente programa parece ser uma melhor alternativa de tratamento do câncer do colo do útero E III, necessitando, contudo, maior observação.
Tumores Germinativos Avançados - Tratamento com PVB
Authors: Gomes Filho Firmino de Azevedo , Viola Sandra Regina de Souza
Published: August 2023

Treze pacientes portadores de tumores germinativos avançados foram tratados nos últimos três anos no Hospital de Oncologia --- INAMPS com esquema quimioterápico PVB. Destes, um paciente não é avaliável visto ter recebido dois ciclos incompletos e somente um tem apresentação extragonadal, sendo os demais primitivos do testículo. Oito pacientes apresentaram PC (66,7%) e quatro RP (33,3%). Duas recidivas ocorreram 12 e 16 meses após início da quimioterapia. Houve três óbitos, após RP dois por falha ao esquema de 2. linha (VP16 + CDDP) e um por evolução de doença após abandono de tratamento durante esquema de 2.' linha. Somente um paciente recebeu dois ciclos de quimioterapia que corresponde a tumor metacrônico. O período médio de acompanhamento é de 21 meses (oito a 39 meses). A média de ciclos é 3,8. O esquema é eficaz, a tolerabilidade muito boa, porém é necessário maior tempo para confirmarmos o percentual de remissão.
ГРАФІЧНИЙ ДИЗАЙН ЯК ПОТУЖНИЙ ПОПУЛЯРИЗАТОР НАЦІОНАЛЬНОЇ СПАДЩИНИ (НА ПРИКЛАДІ ВИРОБІВ У ТЕХНІЦІ ВИТИНАНКИ)
Authors: Світлична Олена Миколаївна , Удріс Ірина Миколаївна , Залевська Олена Юріївна
Published: August 2023

Війна в Україні викликала небувалий інтерес до вітчизняної національної спадщини, українського етнічного стилю, культурних витоків не тільки всередині країни, а й далеко за її межами. Одним із традиційних та поширених видів декоративного мистецтва України є витинанка, що за своїми візуально-декоративними якостями є найбільш вишуканим, ошатним та велично-лаконічним у своїй стриманості мистецтвом. Крім того, сучасна витинанка, як майже незалежний від технічних та технологічних обмежень вид творчості, стала активно генерувати розмаїті комбінаторні варіації орнаментального мистецтва у всій його красі. Більше того, сучасні комп’ютерні та поліграфічні технології, що традиційно вважалися базою виключно графічного дизайну, почали активно включатися у виробництво та швидке поширення витинанки практично у всіх видах дизайнерської творчості від скромних за розмірами (а не за декоративними якостями) святкових листівок чи ажурних упаковок до величних як за розмірами, так і за композиціями елементів інтер’єрів чи екстер’єрів. І окрему цікаву групу складають твори предметного дизайну в техніці витинанки, такі як абажури до освітлювальних приладів чи мереживні світильники, орнаментальні міжкімнатні перегородки чи розсувні ширми, абстрактні об’ємні декоративні прикраси типу «мобілів» або цілком конкретні, але «альтернативні» дизайнерські новорічні ялинки. У статті висвітлено та обґрунтовано базову роль сучасного графічного дизайну для популяризації витинанки. Показано необмежені можливості тиражування виробів різного ступеня орнаментальної складності та різних розмірів: від найменших із традиційного паперу чи картону до найбільших із дерева, пластику чи навіть бетону. Отже, можливість значного тиражування далекоглядно інтегрує витинанку в масовий вжиток для подальшого проникнення у сучасний споживчий простір, що може вплинути, в тому числі, на суттєву корекцію в сторону позитивного сприйняття у ставленні до традиційних вітчизняних культурних кодів.
The Memory of a Place
Authors: NoorMohammadi Susan
Published: August 2023

This paper focuses on the perceptual-phenomenological experience of place in the Faculty Housing built for professors of Jondishapour University (Shahid Chamran) in the city of Ahvaz in Iran. Based on an historical overview of Ahvaz, the paper employs a phenomenological approach to examine how the memory of childhood home as an inhabited space is associated with sensory engagement and how it is experienced differently over time. Faculty Housing was built in 1967–72 and was designed by the prominent Iranian architect Kamran Diba. Taking into consideration the significant sociocultural factors affecting Ahvaz in 1979–2018, this paper aims to examine and interpret the housing’s architectural and urban images, which have changed considerably over time and are now fallen into disrepair, with a loss of their vital and live atmosphere of the past. In order to achieve this goal, it examines and analyses a number of photographs from the creation of this residential complex and its present status. These include images of different architectural, urban, and landscape features as well as semidetached houses, apartments, the local shop, school, play areas, green spaces, separating brick walls, pools, and benches. In addition, the experiences of twenty-one former inhabitants of Faculty Housing are analysed and constructed through a survey questionnaire, the findings of which suggest that Gaston Bachelard’s phenomenological approach supports the comparative analysis of our imagined past experiences of a special place and new experiences after a considerable passage of time.
The Interdisciplinary Party
Authors: Dagan Hanoch , Kreitner Roy
Published: August 2023

The inaugural issue of Critical Analysis of Law is an opportunity to reflect on the distinctive contribution of legal theory to the interaction between law and its neighboring disciplines. This brief exploratory essay suggests that interrogating the law as a set of coercive normative institutions serves as a useful point of orientation for disciplinary interaction. In particular, we suggest that attention to coercive normative institutions can help legal scholars in the tasks of selecting extra-disciplinary materials, integrating those materials into legal analysis, and synthesizing various disciplinary contributions.
Law and Interdisciplinarity: On the Inevitable Normativity of Legal Studies
Authors: Smits Jan M.
Published: August 2023

The field of legal studies is undergoing rapid changes of a highly diverse nature. Increasing specialization, globalization, the rise of interdisciplinary legal studies, and a growing separation of legal research and teaching prompt the question: What is the aim and method of legal studies? The approach advocated in this article provides a contextual model of legal scholarship. Its most important feature is that the basis for autonomous legal studies lies in the fact that it offers a method of analysis. Legal studies look at the world through the lens of what people ought to do in law. This puts “Law and …” approaches in context: it is impossible to carry out meaningful interdisciplinary work in the law without giving center stage to the question of what the law ought to be. This article explores the consequences of this “inevitable normativity” of legal studies for future academic research and teaching.