bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience in the therapy of iron deficiency anemia in pregnant women
Authors: Medvedeva Irina N. , Khuraseva A. B
Published: September 2020

There was executed the examination and treatment of 68 pregnant patients with diagnosed mild iron deficiency anemia (IDA) at gestational age from 12th to 34th weeks. There was estimated the efficacy of the combine preparation of iron and trace elements (iron gluconate, copper gluconate, manganese gluconate) in the treatment of IDA. Early detection of IDA, timely prevention and treatment with the use of this preparation allowed to reduce the rate of obstetric and perinatal complications.
Uterine myoma: modem aspects of pathogenesis and treatment (clinical lecture)
Authors: Kudrina Elena A. , Baburin Dmitry V.
Published: September 2020

In the clinical lecture there are considered modern aspects of pathogenesis, risk factors, diagnosis and treatment of uterine myoma - one of the most common diseases in females of reproductive and menopausal age. Among the major pathogenetic mechanisms of the development of uterine myoma the special attention has been paid to gene and chromosomal aberrations, disturbances of carbohydrate and fat metabolism, chronic inflammatory responses. There was emphasized the attention to modern organ-saving methods of the management of uterine myoma with taking in account the clinical course of the disease, probable complications. There are considered possibilities of various modalities of hormonal therapy as preoperative preparation and prevention of recurrences of uterine myoma after the execution of the organ-saving surgery.
Taking ecto- and endocervical scrapings for the cytological study
Authors: Kaptilnyy V. A
Published: September 2020

In the article there is presented the technique of taking ecto- and endocervical scrapings for the cytological method of research. There are described in details the various techniques used in routine clinical practice. Particular attention is paid to the quality of the collecting cytological sample - technique of taking samples of cellular material. There is described the preparation to the study, readings and research goals. The accompanying photos illustrate in detail all the stages of the cytological screening of the uterine cervix.
Modern approaches to the management of patients with chronic endometritis
Authors: Unanyan Ara L. , Kossovich Yu. M
Published: September 2020

Chronic endometritis is the clinically relevant nosological form requiring the timely detection and treatment. Comprehensive stepped and pathogenetically grounded therapy for chronic endometritis in most of cases leads to the restoration of morphofunctional potential of the endometrium and as a consequence, it contributes to the successful implementation of the reproductive function.
Metabolic syndrome
Authors: Sosnova Elena A.
Published: September 2020

Metabolic syndrome characterized by tissue insulin resistance, hyperinsulinemia, impaired glucose tolerance, essential hypertension, dyslipidemia, and abdominal obesity and hyperuricemia in the same patient, not accidentally is causing the great interest of researchers. In clinical lecture there are presented data concerning both different variants of the metabolic syndrome (MS) and its prevalence rate in the population. There are given as well diagnostic criteria for MS as algorithm of examination ofpatients. There is considered the concept of the treatment of metabolic syndrome.
Tactics of the management of patients with atypical endometrial hyperplasia
Authors: Baburin Dmitry V. , Unanyan A. L
Published: September 2020

This review deals with modern aspects of the management of patients with endometrial hyperplasia with atypia. There are considered modalities of different types of drug therapy and surgical treatment.
LAPAROSCOPIC DRILLING OF OVARIES: PRO AND CONTRA
Authors: Yusubova V. R
Published: September 2020

Laparoscopic ovarian drilling is now considered to be a safe and effective surgical method. The frequency of the onset of pregnancy is similar tothat of the therapeutic methods of ovulation induction. At the same time, a lower risk of ovarian hyperstimulation syndrome and multiple pregnancies makes drilling more preferable to gonadotropin therapy. Despite the advantages of this method of surgical treatment, the issue of possible complications still remains to be relevant.
POSSIBILITIES FOR PREGNANCIES AND DELIVERIES IN SUCCESSION TO THE TREATMENT OF BREAST CANCER
Authors: Zikiryakhodzhaev A. D , Novikova O. V , Rasskazova Elena A.
Published: September 2020

In the article there is presented information about 9 patients of young age who delivered a child after the treatment in the P.A. Herzen Moscow Research Oncological Institute for malignant breast neoplasms. Oncological aspects of the treatment in patients, data on subsequent pregnancy and lactation were analyzed in detail. The length of the follow-up period for patients and children amounted to 12 to 84 months. Only one (11.1%) of the nine patients had breast cancer progression after delivery in the form of a metastatic ovarian lesion. Dynamic following up this group of patients is carried out.
THE ROLE OF BIOCHEMICAL MARKERS IN THE RISK STRATIFICATION FOR DEVELOPMENT OF PREECLAMPSIA: THE CLINICIAN’S VIEW
Authors: Ignatko I. V , Florova Violetta S. , Kuznetsov A. C , Kuzina E. Yu
Published: September 2020

Preeclampsia is one of the main causes of maternal mortality and leads to 50-60 thousand deaths annually worldwide, its prevalence in the world is 5-8%. Moreover, this complication is associated with an increased risk of the development of cardiovascular diseases and diabetes in the mother and child. Preeclampsia is a multi-systemic syndrome including hereditary and environmental factors in its pathogenesis and pathophysiology, and the only effective method of the treatment is still delivery. Regardless of the time of debut, preeclampsia is often characterized by the relative well-being of a pregnant woman, right up to the development of severe pre-eclampsia. This review is devoted to biochemical markers of the high risk of pre-eclampsia. Of particular interest there is the balance of proangiogenic (PIGF) and anti-angiogenic (sFlt) growth factors at different gestational ages; both the correct interpretation of the sFlt/PIGF balance and the correlation with the history data already allow us to expand the criteria for the prevention of preeclampsia and open up prospects for optimizing obstetric tactics in the third trimester of pregnancy.
CLINICAL AND MORPHOLOGICAL FEATURES OF CHRONIC ENDOMETRITIS IN INFERTILE WOMEN
Authors: Unanyan Ara L. , Kossovich Yu. M , Demura T. A , Baburin D. V , Sidorova I. S , Ishchenko A. I
Published: September 2020

Morphofunctional state of the endometrium is one of the key factors determining both the successful implantation and full development of the embryo, including in cycles of «in vitro fertilization» (IVF). The most common cause of the impairment of the structure and function of the endometrium being chronic endometritis (CE), the frequency of its detection in infertile patients varies between 13 and 68%, reaching its maximum in women with tubal peritoneal factor and unsuccessful attempts of IVF in the anamnesis. The increasing prevalence and steady growth of the currently occurrence rate of CE cases in infertility is promoted by an increase in the role of intrauterine contraception and intrauterine interventions, including artificial abortions. On the other hand, happened in the last decades the evolution of the etiologic factor of CE towards the predominance of associations of facultative and obligate anaerobic microorganisms and viruses in the endometrium often leads to the development of erased, sluggish and atypical forms of the disease, which significantly hamper the diagnosis of CE and significantly reduce the effectiveness of traditional schemes of its treatment. CE is a clinically significant nosological form requiring the timely detection and treatment. The complex phased and pathogenetically substantiated therapy of CE in most cases leads to the restoration of the morphofunctional potential of the endometrium and, as a consequence, promotes the successful realization of the reproductive function.
EPIDURAL ANALGESIA AND LABORS IN WOMEN WITH A UTERINE SCAR: WHAT IS THE DEGREE OF RISK?
Authors: Bozhenkov Konstantin A. , Gustovarova T. A , Shifman E. M , Vinogradov V. L
Published: September 2020

The article presents the results of a prospective controlled longitudinal study involving 69 reproductive women with a uterine scar after a cesarean section in previous labor. In women included in the study births were performed vaginally. Patients were divided into two groups: the first group consisted of 38 women with a uterine scar, whose vaginal deliveries were anesthetized by the method of epidural analgesia; the second group included 31 multipara patients with a uterine scar, in which the births were carried vaginally without epidural analgesia. Over the course of a study epidural analgesia was shown to be effective method of anesthetizing labor in women with a uterine scar. Epidural analgesia in vaginal delivery in women with a uterine scar is concluded do not influence on the risk of untimely diagnosis of the beginning uterine rupture. Diagnostic criteria for the beginning uterine rupture on the background of epidural analgesia should be considered for any of following criteria: the emergence of a severe pain syndrome, not associated with the contractile activity of the uterus; signs of the sudden deterioration of the state of the fetus; change in the fetal heart rate; change in the tone of the uterus and the nature of its contractions; termination of labor activity; a sudden change in one or more vital signs of the parturient (BPmean, HR, RR).
MULTILEVEL SURGICAL CORRECTION OF POSTGISTERECTOMIC GENITAL HERNIA
Authors: Ishchenko A. I , Aleksandrov L. S , Ishchenko A. A , Gorbenko O. Yu , Khokhlova Irina D. , Gavrilova T. V , Gadaeva I. V , Tarasenko Yu. N
Published: September 2020

The article presents a new surgical method for correcting posthisterectomic genital hernia, accompanied by bilateral paravaginal defects. Despite the use of many surgical techniques and high-tech materials for the prevention and treatment of posthisterectomic genital hernia, the prevalence rate of this pathology fails to decline, but on the contrary, for many reasons, it tends to grow, which calls for the development of new surgical methods of the treatment. The proposed surgical program of multilevel correction of posthisterectomic genital hernia with bilateral paravaginal defects, providing multifocal fixation of anatomical structures with polypropylene implants, will improve clinical results and their duration, as well as the fall of the prevalence rate of relapses of the disease.
BLEEDINGS IN THE HIGH-RISK GROUP OBSTETRIC HOSPITAL
Authors: Guseva Elena M.
Published: September 2020

Massive hemorrhage and hemorrhagic shock as main causes of deaths in pregnancy, occupy up to 25% in the structure of mortality rate in obstetrics. In the past decade, the decline in the share of deaths of mothers has occurred due to postpartum bleedings and bleedings in detachment or placenta previa. The aim of the study was to determine the frequency and structure of massive bleedings in a high-risk group obstetric hospital. Methods. A retrospective descriptive cohort study was executed in 2 stages: at the 1st stage - a study of 396 deliveries histories with main nosological forms leading to possible pathological hemorrhage, in the II stage - analysis of 55 cases of massive blood loss. The object of the study was puerperas with placenta previa; puerperas with deliveries complicated by hypotonic bleeding or premature detachment of the placenta; puerperas with the massive blood loss. Duration of the study: from 01.01.2011 to 31.12. 2015. Results. The most frequent nosological form leading to abnormal blood loss is premature placental abruption. The frequency of cases of massive blood loss (more than 1000 ml) is 0.28% of the total number of deliveries and is more common in primigravidae (56.4%), mainly during surgical delivery (88%). Out of all massive bleedings, 45.5% are due to uterine hypotension. Amputation of the uterus was performed in 18.2% of the number of all cases of the massive hemorrhage. Conclusion. The high prevalence rate of the premature detachment of the placenta is explained by the uncontrollability of this pathology, in contrast to hypotonic bleeding in the postpartum period. The organ-preserving management in massive obstetric hemorrhages is not widely used.
MODERN IDEAS ABOUT THE MANAGEMENT OF LABOR IN HIGH-DEGREE MYOPIA
Authors: Aslamazova A. E , Fokina N. D , Berishvili M. V , Bykova E. L , Berishvili T. Z , Krasilshchikov Ilya M.
Published: September 2020

The increase in the incidence of myopia and peripheral chorioretinal dystrophies in patients of childbearing age leads to the appearance of new methods of vision correction, as well as to the formation of new standards of medical care in the management of pregnancy and delivery.
POLYMORPHISM OF SOME GENES IN PATIENTS WITH CHRONIC ENDOMETRITIS
Authors: Kobaidze Ekaterina G. , Padrul M. M
Published: September 2020

Chronic inflammation of the endometrium is one of the causes of infertility and impaired menstrual function. The issues of the diagnosis and treatment of this disease are often discussed, but remains too unclear. In connection with this, the study of the role of genetic polymorphism in patients with chronic endometritis is topical. The occurrence of polymorphisms in promoter sites of VEGF, ApoE, ESR1, PPARGC1A, MMP9, eNOS genes in patients with chronic endometritis and in practically healthy women were studied. As primers, the DNA portion of the VEGF genes rs2010963 (G634C), ApoE rs429358 (Cys130Arg), ESR1 2228480 (Thr594Thr), PPARGC1A 8192678 (Gly482Ser), MMP9 17576 (Gln279Arg), and eNOS 1799983 (Glu298Asp) were used. To study the polymorphic variants of genes investigated, a real-time polymerase chain reaction was used, the material was sampled by smear extraction from the mucous membrane of the oropharynx. In the analysis, the percentage of homozygotes and heterozygotes, the prevalence of the normal and pathological (minor) allele were counted. Based on the results obtained, it can be assumed that in patients with chronic endometritis polymorphism of genes responsible for angiogenesis, oxidative processes in the body and metabolism is more common. In particular, there was noted a statistically significant predominance of polymorphism in the promoter sites of the eNOS and ESR1 genes in patients with chronic endometritis, which may be indicative of negative genetic associations with impaired fertility; at the same time, the issues of the presence of genetic polymorphism of the genes MMP9, VEGF and ApoE and a lower frequency of somatic and gynecological pathology in a group of practically healthy women require further study.
EXPERIENCE OF LAPAROSCOPIC CORRECTION OF FAILURE OF THE UTERINE SCAR AFTER THE CESAREAN OPERATION
Authors: Bryunin D. V , Mikhayelyan N. S , Khokhlova Irina D. , Dzhibladze T. A , Ishchenko A. I , Gorbenko O. Yu , Gavrilova T. V , Gadaeva I. V
Published: September 2020

The article presents the results of laparoscopic correction of the failure of uterine scar after a cesarean section operation in 12 patients of reproductive age who are planning another pregnancy and having clinical symptoms that significantly impair the quality of life. The developed by ourselves three-stage reconstructive-plastic surgical program with the laparoscopic access in case of incompetence of the uterine scar contributed to an improvement in the quality of life in all subjects, pregnancy, and childbirth in 41,6% of patients. The use of laparoscopic techniques provided an improved visualization of anatomical structures (vessels, nerves, ureters, bladder), which led to a decrease in intraoperative blood loss, a reduction in the risk of damage to adjacent organs and the development of adhesions, and acceleration of postoperative rehabilitation of patients.
COMPARISON OF DIAGNOSTIC METHODS AND TREATMENT OF ENDOMETRIOSIS OF ATYPICAL LOCATION
Authors: Shlyk D. D , Kitsenko Yury E. , Markaryan D. R , Lanchinskiy V. I , Tulina I. A , Tsarkov P. V
Published: September 2020

Surgical treatment and subsequent management of women of reproductive age with endometriosis of extragenital localization involving intestine, whose frequency is up to 37%, currently do not have a detailed and clearly described protocol, which may be caused by the complexity of diagnosis at the preoperative stage. In most cases, extragenital localization is an intraoperative finding. The purpose of the article is to evaluate the complexity of diagnosing the atypical location of extragenital endometriosis, systematize the diagnostic protocol and present the chosen treatment tactics. Material and methods. In the clinic of coloproctology and minimally invasive surgery, 4 observations of extragenital endometriosis with intestinal lesions were noted. According to the results of diagnostic studies (multispiral computed tomography - MSCT of the abdominal cavity with intravenous contrast, irrigoscopy with double contrasting, colonoscopy with biopsy), endometriosis was confirmed in 2 patients at the preoperative stage. All patients underwent surgical interventions in the volume of resection of the affected segment of the intestine within the unchanged tissues. Results. According to the intraoperative revision, in all patients there was noted the presence of additional extragenital foci of different localization, which were destroyed by diathermocoagulation. Patients with unverified endometriosis also underwent lymphadenectomy in D2 volume due to the inability to exclude malignant neoplasm. In the early postoperative period, no complications were noted. Only 1 patient decided to take hormonal therapy for 6 months after the operation. At present, none of the relapses have been observed, the mean follow-up time is 17.3 ± 13.6 months (4-33 months). In all patients there was recovered the menstrual cycle, menstruation moderately painful, previous abdominal pains before menstruation and spotting discharges from the rectum stopped. Conclusion. Surgical treatment of extragenital endometriosis of intestinal localization in the volume of resection of the affected intestine within the unchanged tissues is the optimal treatment technique and is not accompanied by significant complications. However, in cases of unverified histologically endometriosis, principles of oncological radicalism should be kept. To select the optimal volume of surgical intervention and access, a multidisciplinary consultation with the coloproctologist, gynecologist and with the obligatory consideration of the patient’s opinion is required.
PREDICTORS OF THE DEVELOPMENT OF SYNDROME OF THE HYPER-INHIBITION OF GONADOTROPIC FUNCTION OF THE HYPOPHYSIS FOLLOWING LONG-TERM INTAKE OF COMBINED ORAL CONTRACEPTIVES
Authors: Aksenova A. V , Sosnova E. A
Published: September 2020

The review presents information on the syndrome of hyper-inhibition of gonadotropic function of the pituitary gland (HIGHFG) developing in patients against the background of a long (from a year or more) intake of combined oral contraceptives. This syndrome is presented in the form of secondary amenorrhea after drug withdrawal. Depending on the severity, moderate and full forms of the syndrome are separated. The pathogenesis of the development of HIGHFG, diagnostic criteria, clinical and laboratory predictors of the development, and preventive measures are considered.
DISABILITY OF PREGNANCY IN PATIENTS WITH “NON-CRITERIA” FACTORS PREDISPOSING TO THE DEVELOPMENT OF THROMBOPHILIA: A MODERN VIEW ON THE PROBLEM
Authors: Baymuradova Seda M. , Slukhanchuk E. V
Published: September 2020

Many practitioners in our country diagnose thrombophilia when detecting thrombogenic mutations, as well as antiphospholipid antibodies. At the same time, there is a rejection of thrombophilia in the genesis of obstetric complications, and its overdiagnosis in healthy women. The incidence of polymorphisms and mutations included in the classification of thrombophilia (the so-called “criterion” forms) among patients with obstetric complications is low. The frequency of hypercoagulable states in patients with obstetric complications is much higher, and their use of pathogenetic therapy leads to a positive outcome. In such patients, combinations of “non-criteria” forms of thrombophilia, a combination of polymorphisms in the genes of one coagulation unit, a combination of hereditary and acquired thrombophilia are detected. The study, which included 350 patients, including early pre-embryonic losses (failures of assisted reproductive technologies, biochemical pregnancy) - 59, spontaneous abortions - 223, antenatal death of the fetus - 68, demonstrated the importance of thrombophilia in the genesis of obstetric complications. The clinical implementation of thrombophilic defects has been shown to be possible both with point “criterion” mutations of thrombophilia and their combination, and with a combination of defects of the hemostasis system, including “non-criteria”, polymorphisms and mutations of genes in one link of the hemostasis system, with combinations of mutations and/or polymorphisms with acquired thrombophilia and/or risk factors.
LEPTIN LEVEL IN WOMEN OF REPRODUCTIVE AGE WITH THE SYNDROME OF THE POLYCYSTIC OVARY IN COMPARISON WITH HEALTHY WOMEN
Authors: Beglova Anzhelika Yu. , Elgina S. I
Published: September 2020

Material and methods. The study included 200 women of reproductive age, of whom the 1st group included 100 PCOS female patients and the 2nd group included 100 healthy women examined using clinical, instrumental, laboratory, and statistical methods. Results. Metabolic syndrome was diagnosed in 38 (38.0%) PCOS women of early reproductive age, while in healthy women only in 25 (25.0%) (p = 0.102). The serum leptin content in PCOS women amounted of 13.85 ng/ml (4.15-17.6), which was not significantly different from that of healthy women - of 8.9 ng/ml (5.5-18.4) (p = 0.732). However, in women with manifestations of metabolic syndrome (overweight and obesity), the level of leptin was higher than in women without metabolic syndrome - 16.7 ng/ml (15.6-18.8) and 19.3 ng/ml (17.4-22.8) in PCOS women - 31.7 ng/ml (21.6-38.6) and 27.3 ng/ml (20.1-32.1) in healthy women (p = 0.045 and 0.604, respectively). An increase in its level correlated with an increase in BMI (p = 0.001). We found that an increase in leptin levels in PCOS women of reproductive age correlated with its main manifestations: menstrual disorders, infertility and ultrasound parameters of the ovaries, with an increase in BMI, the relationship was stronger. Conclusion. Thus, in PCOS women of reproductive age, metabolic syndrome is more often diagnosed than in healthy women. Overweight and obesity are of major importance in the formation of metabolic disorders. Increased leptin levels exacerbate metabolic manifestations, leading to impaired ovulation and fertility. The results show the need to determine the level of leptin as an additional diagnostic criterion for metabolic syndrome in PCOS cases.
INTEGRATED PREPARATION OF PREGNANT WOMEN WITH A UTERINE SCAR TO VAGINAL PARTURITION
Authors: Shevtsova E. P , Miroshnikov Anatoly E. , Shatilova Yu. A , Zharkin N. A
Published: September 2020

Attempts of vaginal delivery in cases with a scar on the uterus after a previous cesarean section are more successful after appropriate psycho-prophylactic preparation during pregnancy. The purpose of the study is to reduce the frequency of repeated cesarean section operations. A comparison was made of the methods of delivery for pregnant women with a scar on the uterus after comprehensive training on an improved program and unprepared pregnant women. A total of 158 women were included in the study. Among them were those who had a cesarean section in history, but not trained for the current childbirth, only 5% gave birth independently. At the same time, women trained under the improved program had independent deliveries in 45.6% of cases (OR 5.813; 95% CI 0.826-40.885). The results confirm the effectiveness of the proposed improvements in the preparation of pregnant women with a scar on the uterus. The intention of such women to give birth through the natural birth canal, formed as a result of preparation, is an important factor for successfully overcoming the difficulties of the delivery process.
ATYPICAL HEMOLYTIC-UREMIC SYNDROME DURING PREGNANCY. PRESENT AND LATEST RESULTS OF TREATMENT
Authors: Zharkin N. A , Statsenko M. E , Stazharova M. M , Burova Natalia A. , Prokhvatilov S. A
Published: September 2020

Atypical hemolytic-uremic syndrome being referred to autoimmune diseases appears to be one of the most severe forms of thrombosis and microangiopathy. Difficulties in diagnosis cause a delay in pathogenetic therapy, which causes a high maternal mortality rate. Pathogenetic therapy with eculizumab, suppressing the terminal activity of complement, may contribute to the recovery of blood coagulation properties, but the long-term prognosis for chronic renal failure remains unfavorable. The article deals with a clinical case confirming this conclusion.
DEPLETION OF OVARIAN RESERVE IN EXTERNAL ENDOMETRIOSIS - NOT A SENTENCE
Authors: Kalseidova Kristina Sh. , Bakhtiyarov K. R
Published: September 2020

Endomeriosis is rightly called a mystery of the XXI century. In some cases, this disease requires constant monitoring and treatment. This clinical case demonstrates the outcome of multiple surgical treatment of ovarian endometriosis - a spontaneous, long-awaited pregnancy that occurred 2 years after signs of an exhausted ovarian reserve.
FEATURES OF THE COURSE OF PREGNANCY AND GENERA IN PATIENTS WITH OBESITY
Authors: Timokhina E. V , Saakyan Mariam G. , Zafiridi N. V , Bogomazova I. M
Published: September 2020

The aim of the study was to assess the course of pregnancy and childbirth in patients with varying degrees of obesity.Material and methods of research. A retrospective study of pregnant women with different body mass index (BMI), the delivery of which occurred in the period 01.01.2018-06.30.2018, was conducted. The results of the study. In the study, the largest proportion - 53% were pregnant women with a BMI above 30 kg/m2, the proportion of women with premorbid obesity - 47%. The incidence of diseases that complicate the course of pregnancy (chronic hypertension, gestational hypertension and preeclampsia) was highest in women with a BMI higher than 30 kg/m2. In the study groups, gestational arterial hypertension was the most common - 14%. Pregnancy complications, namely, fetal growth retardation/placental insufficiency, occurred with a frequency of 8% in the group with premorbid obesity. In pregnant women with a BMI of more than 30 kg/m2, acute/chronic fetal hypoxia was observed, the frequency of which in total was 10%. Complications of the fetus in the studied women showed that the risk of fetal hypoxia in pregnant women with a BMI above 30 kg/m2 is very high. Large fruit was found in 15% of cases of the total number of women studied, in groups with a BMI of more than 30 kg/m2, with a frequency equal to 10% of the total number. The number of births through the birth canal in women with a BMI of more than 30 kg/m2 was 28%, and the frequency of cesarean section operations was 24%. Conclusion. Women with a BMI above 30 kg/m2 have a high frequency of pregnancy complications (gestational arterial hypertension, preeclampsia, chronic arterial hypertension). A high frequency of perinatal pathology was revealed - acute/chronic fetal hypoxia, placental insufficiency, fetal growth retardation, macrosomia. Pregnant women with a high BMI should be closely monitored by an obstetrician-gynecologist, observe proper nutrition, monitor weight gain, and timely treat chronic diseases, in particular hypertension.
MODERN POSSIBILITIES OF IRON DEFICIENCY ANEMIA TREATMENT IN ONE VISIT
Authors: Ozolinya Lyudmila A. , Shirenina A. A , Kulinicheva E. A
Published: September 2020

The iron deficiency anemia remains a current problem, despite new methods of treatment. According to the statistics, every fifth woman of reproductive age has manifestations of iron deficiency that worsens quality of her life. The modern way of life causes need for fast and effective treatment. We carried out the analysis of information on treatment of an iron deficiency anemia by oral (ferri sulfas, ferric (III) hydroxide polymaltosate ) and intravenous (ferric (III) hydroxide olygoisomaltosate, ferric (III) carboxymaltosate, ferric (III) sacharose complex) iron preparations and red blood cell transfusion. On the basis of studying of scientific articles, we established that ferric (III) hydroxide olygoisomaltosate has the most effect and fast effect for treatment of iron deficiency medium and heavy gravity.
CLINICAL CASE OF A SUCCESSFUL PREGNANCY WITH THE COMPLETE FORM OF GONADAL DYSGENESIS - SWYER SYNDROME
Authors: Timokhina Elena V. , Afanas’yeva N. V , Samoylova Yu. A , Silayeva T. M , Belousova V. S , Lomovtseva M. M , Seyfullayeva L. I
Published: September 2020

Swyer syndrome (46,XY complete gonadal dysgenesis) is a rare chromosomal pathology. This pathology occurs with a frequency of 1 in 80,000. In genetic analysis, mutations are most often found in the following genes: the SRY gene, the NR5A1 gene, the SOX9 gene, the MAP3K1 gene. Patients with this disease develop phenotypically as women, but due to the absence of gonads and eggs, independent pregnancy is impossible. This article describes a clinical case of a successful onset, course of pregnancy and delivery in a woman with Swyer syndrome using assisted reproductive technology.
Possibilities of using the SMARTXIDE2 V2LR laser system after reconstructive plastic surgery with use mesh prostheses for genital prolapse
Authors: Shul’china I. V. , Ishchenko A. I. , Ishchenko A. A. , Gilyadova A. V.
Published: September 2020

Introduction. Prolapse of pelvic organs is a polyetiological disease, manifested by a displacement of the uterus and he vaginal walls to the genital slit and/or by going beyond it. The urgency of the problem of prolapse of pelvic organ is associated with a tendency for an increase of morbidity in both elderly women due to increased expectancy of life and women of the reproductive period.

Material and methods. The study included 62 patients, age of them was 4275 years. All women were underwent surgical correction with a transvaginal installation of the front mesh implant Gineflex with intraoperative extraction of fragments of the mucous membrane of the anterior wall of vagina with subsequent histological examination, as well as fragments of the mesh prosthesis after its installation and processing of the vaginal mucosa of the SmartXide2 V2LR laser system. Patients were separated on the two group taking into account the operating mode parameters of the fractional CO2 laser. In the 1st group, with a total laser energy of exposure 8.13 J/cm2, included 32 patients, in the 2nd, with a total laser energy of impact 1.48 J/cm2, 30 patients. Transvaginal installation of the anterior mesh prosthesis Gineflex was complemented such the surgical interventions as extraperitoneal ligature hysterosuspension, posterior colporography, colpoperineoplasty, installation of Urosling, Manchester operation, supravaginal uterine amputation, adnexectomy in depending on the accompanied pathology.

Results. In the patients were determined IIIV stages of genital prolapse with using the POP-Q assessment system. During histological examination of a sample of biopsy of the vaginal mucosa, the thickness of walls ranged from 155 to 628 m. During microscopy on fragments of mesh prostheses in the 1st group, fragmentary destruction of the fibers of all formed was noted, which not have been detected in the examination of a samples of patients of the 2nd group, where the total laser energy was less on 6.65 J/m2.

Conclusion. In patients with surgical correction of genital prolapse with using of a mesh implant upon the using the certain characteristics of SmartXide2 V2LR laser system for the exposure of the vaginal mucosa occurs partial destruction of the fibers of the mesh prosthesis, which allows to reduce the degree of tissue tension and consequently allows to reduce the level of complications after surgical diseases is associated with implantation a mesh prosthesis that does not reduce the effectiveness of this surgical treatment. This technique is safe, has no restrictions on the age and somatic status of patients, increases the tolerance of the postoperative period of surgical correction.
Celly, Meire e Regiane
Authors: Morelli Rita de Cássia Lahoz
Published: September 2020

Este artigo, que resulta de pesquisa financiada pela Fapesp, analisa as trajetórias das cantoras Celly Campelo, Meire Pavão e Regiane no disco e na televisão de São Paulo, entre as décadas de 1950 e 1960, com ênfase em sua experiência como mulheres e como artistas no contexto de um movimento musical marcadamente masculino, como foi o rock paulista pré-Jovem-Guarda. Em suas decisões profissionais e artísticas, as três sofreram influência semelhante de figuras masculinas que de alguma forma também as protegiam dos riscos ainda associados naquela época ao trabalho no rádio e na televisão por parte de mulheres. Celly foi influenciada por seu irmão, o cantor e compositor Tony Campello. Meire Pavão sofreu influência de seu pai, Theotônio Pavão, compositor e professor de violão, e de seu irmão, cantor e compositor Albert Pavão, autores de quase todas as músicas que veio a gravar. Regiane, aluna do mesmo Professor Pavão, saiu de sua órbita de influência após contrato com o selo Young, dirigido pelo produtor Miguel Vaccaro Neto, apenas para cair sob a órbita de influência deste. As três abandonaram suas carreiras mais ou menos prematuramente, e aventa-se aqui a hipótese de que o tenham feito em razão da forte dissonância existente entre a formação musical e moral que receberam como meninas na década de 1950 e o modelo de “juventude transviada” que estava associado ao ritmo musical a que se dedicavam.
Vanguardia primitiva en el rock chileno de los años setenta
Authors: González Juan Pablo
Published: September 2020

En este artículo propongo el concepto de vanguardia primitiva para caracterizar la práctica experimental de la primera época del grupo chileno de rock de fusión Los Jaivas (1970), de impacto en Chile a comienzos de los años setenta y en Argentina y Francia a partir de su auto-exilio de 1974. Herederos de la cultura hippie californiana, Los Jaivas encontraron en la cultura amerindia una especie de hipismo esencial, desde la cual se acercaron a dos vanguardias: la improvisación aleatoria y las grandes formas del rock progresivo. Me interesa indagar el modo de representación de lo indígena y la construcción de una vanguardia primitiva en las primeros grabaciones de Los Jaivas y sus discursos asociados.
Centro Cultural da Juventude
Authors: Vicente Eduardo , Soares Rosana
Published: September 2020

Este trabalho se propõe a discutir a cultura musical da periferia da cidade de São Paulo (Brasil) através da análise das produções desenvolvidas no Centro Cultural da Juventude (CCJ), um importante espaço cultural público localizado na Zona Norte da cidade. A intenção do texto é concentrar-se na diversidade musical produzida no local ou oferecida em sua programação, entendendo que ela expressa, em grande medida, a riqueza étnica e cultural da metrópole. A escolha do CCJ como ponto de observação privilegiado dessa produção deve-se, em primeiro lugar, ao fato de que o centro é um importante espaço de debate e valorização da música independente do Brasil, organizando frequentemente shows e eventos com artistas e gêneros musicais geralmente distantes do mainstream.  Também por essa razão, o Centro possui, desde 2006, um estúdio de gravação onde são produzidos gratuitamente CDs de artistas e bandas da região.
Cosmopolitismo e world music no Rio de Janeiro na passagem para o século XX
Authors: Magaldi Cristina
Published: September 2020

O foco deste ensaio é a circulação internacional da música enquanto uma força globalizante que permitiu a criação de uma cultura cosmopolita no início do século XX. Meu principal objetivo é oferecer ideias sobre questões ligadas a identidades cosmopolitas e à música popular em geral, e no Rio de Janeiro em particular. Mais do que apresentar o repertório popular do início do século XX em seu potencial para exibir signos de “brasilidade”, mostro a emergência da música popular nessa cidade como parte de um contexto mais amplo de cultura urbana internacional. Estou mais interessada no cosmopolitismo musical emergente e nos primeiros exemplos da “world music” como modas internacionais efêmeras que podem oferecer uma alternativa às interpretações já desgastadas sobre o papel da música nas políticas identitárias do início do século XX no Brasil.
A música e a dança no teatro de revista carioca
Authors: Cascaes Laura Silvana Ribeiro
Published: September 2020

Este artigo tem como objetivo investigar a dança e a música no Teatro de Revista carioca, para analisar as influências do imaginário da modernidade nos números de canto e dança, bem como identificar alguns gêneros musicais incorporados junto à produção da cena revisteira, considerando o bailado do corpo de baile, especialmente as coristas-dançarinas (as chamadas girls) e as rupturas representadas pela modernidade em relação à dança e à música desse período. Pretende-se também destacar a integração de linguagens expressivas e as aproximações e interfaces dialógicas que ocorreram entre a música e a dança no universo revisteiro. Para tal, este artigo se pauta numa abordagem histórica, tendo como procedimento metodológico, estudos existentes sobre este gênero teatral e análise de fotografias. Esta última análise visa observar e identificar aspectos dos gêneros de dança presentes, especialmente as chamadas “danças modernas”, e vestígios das identidades sociais das dançarinas.
Peñas, canción de protesta y transformación política en Chile (1965-1973)
Authors: Mamani Ariel Hernán
Published: September 2020

El presente artículo busca estudiar las peñas folclóricas que florecieron a mediados de la década del 60 en Chile. Estos espacios funcionaron como centros de sociabilidad en locales donde se presentaban números musicales en vivo. Con la asistencia de un público numeroso pero sin llegar a ser masivo se transformaron en sitios donde la discusión política e ideológica también se hizo presente. A su vez resultaron los primeros ámbitos en dar acogida a un movimiento musical que alcanzó relevancia mundial: la Nueva Canción Chilena. El intento es demostrar como las peñas folclóricas fueron un importante centro de discusión y transformación política con una importante tarea de irradiación ideológica y cultural a partir de la práctica musical.
Highly Productive Boreal Ecosystem Chernevaya Taiga - Unique Rainforest in Siberia
Authors: Abakumov Evgeny , Loiko Sergey , Lashchinsky Nikolay , Istigechev Georgy , Kulemzina Anastasia , Smirnov Alexey , Rayko Mikhail , Lapidus Alla
Published: September 2020

Boreal forests are one of the largest stores of carbon on Earth, and two-thirds of them are located in Siberia. Despite the fact that these forests have a significant influence on the global climate, they continue to remain understudied. Chernevaya taiga is a unique example of a highly productive Siberian boreal ecosystem. This type of forest is characterized by a series of unique ecological traits, the most notable of which are the gigantism of the perennial herbaceous plants and bushes, complete lack of moss cover on soil surface, and the type of soil it grows on, notable for its particularly high rate of decomposition of vegetative remains and low humic acid content. Abundant rainfall actively washes out nutrients from the top layers of the soil, but its fertility level remains very high. In fact, based on the existing data, it is twice as high as that of fertilized agricultural lands. In some ways the conditions within this type of forest closely resemble those observed in tropical rainforests. Microbiota associated with soil and plants represent an integral part of an interconnected system and contribute significantly to productive processes in soils. Its impacts on the environment require further study, since it could lead to discoveries that will help improve soil fertility without harming the natural environment.
Omeg@Silica: In-Silica Stabilization of Sustainable Fish Oil
Authors: Lino Claudia , Pagliaro Mario , Ciriminna Rosaria
Published: September 2020

Fish oil rich in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), vitamin D3 and natural astaxanthin sustainably extracted from anchovy fillet leftovers using biobased limonene only, can be conveniently stabilized by adsorption on periodic mesoporous silicas. The simplicity of the process, the high load of entrapped fish oil, and the biocompatible nature of silica support numerous forthcoming applications of this new class of “Omeg@Silica” materials.
Optimal Operation of Conventional Power Generation with High Penetration of Renewable Energy using
Equilibrium Optimizer Technique
Authors: Alhmoud Lina , Nusair Khaled
Published: September 2020

Over the last decades, the energy market around the world has reshaped due to accommodating the high penetration of renewable energy resources. Although renewable energy sources have brought various benefits, including low operation cost of wind and solar PV power plants, and reducing the environmental risks associated with the conventional power resources, they have imposed a wide range of difficulties in power system planning and operation. Naturally, classical optimal power flow (OPF) is a nonlinear problem. Integrating renewable energy resources with conventional thermal power generators escalates the difficulty of the OPF problem due to the uncertain and intermittent nature of these resources. To address the complexity associated with the process of the integration of renewable energy resources into the classical electric power systems, two probability distribution functions (Weibull and lognormal) are used to forecast the voltaic power output of wind and solar photovoltaic, respectively. Optimal power flow, including renewable energy, is formulated as a single-objective and multi-objective problem in which many objective functions are considered, such as minimizing the fuel cost, emission, real power loss, and voltage deviation. Real power generation, bus
13 voltage, load tap changers ratios, and shunt compensators values are optimized under various power systems’
14 constraints. This paper aims to solve the OPF problem and examines the effect of renewable energy resources
15 on the above-mentioned objective functions. A combined model of wind integrated IEEE 30-bus system, solar
16 PV integrated IEEE 30-bus system, and hybrid wind and solar PV integrated IEEE 30-bus system are performed
17 using the equilibrium optimizer technique (EO) and other five heuristic search methods. A comparison of
18 simulation and statistical results of EO with other optimization techniques showed that EO is more effective
19 and superior.
The Status of An Inversely Coupled Oxic/Sulphidic Oscillator (OSO) in the Whole Body Chemocline Will Determine Clinical Unfolding in Systemic Inflammatory Response Syndrome (SIRS)* of Any Aetiology
Authors: Thangaraj Paul
Published: September 2020

Life evolved in an euxinic world with subsequent oxic 'invasion' leading to two parallel but interconnected biospheres, hydrogen sulphide (H2S) and hydrogen peroxide (H2O2) exemplify these worlds respectively. Their concentration gradients have informational value in meromictic lakes. Similarly, it is posited, there exists a whole body chemocline in humans in which the two molecules form an inversely coupled oxic/sulphidic oscillator (OSO). The OSO is hormetic and characterised by a range of amplitudes and frequencies in health. Deviations from its baseline profile heralds the onset of SIRS before the appearance of clinical signs. Loss of oscillator status and transition to a steady state causes widespread intercellular and inter-organ communication failure presaging multi-organ dysfunction. The salient clinico-pathophysiological features of SIRS of any aetiology are emergent phenomena related to the OSO profile. Extent of recovery of organ function will mirror the recovery of the OSO profile thereby providing a tool to predict outcomes in SIRS.
Quantitative Epigenetics: A New Avenue for Crop Improvement
Authors: Gahlaut Vijay , Zinta Gaurav , Jaiswal Vandana
Published: September 2020

Plant breeding conventionally depends on genetic variability available in a species to improve a particular trait in the crop. However, epigenetic diversity may provide an additional tier of variation. The recent advent of epigenome technologies has elucidated the role of epigenetic variation in shaping phenotype. Further, the development of epigenetic recombinant inbred lines (epi-RILs) in the model species such as Arabidopsis has enabled accurate genetic analysis of epigenetic variation. Subsequently, mapping of epigenetic quantitative trait loci (epiQTL) allowed association between epialleles and phenotypic traits. Thus, quantitative epigenetics provides ample opportunities to dissect the role of epigenetic variation in trait regulation, which can be eventually utilized in crop improvement programs. Moreover, locus-specific manipulation of DNA methylation by epigenome-editing tools such as clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) can facilitate epigenetic based molecular breeding of important crop plants.
Thermostatics vs. Electrodynamics
Authors: Eisenberg Robert S.
Published: September 2020

Thermodynamics has been the foundation of many models of biological and technological systems. But thermodynamics is static and is misnamed. A more suitable name is thermostatics. Thermostatics does not include time as a variable and so has no velocity, flow or friction. Indeed, as usually formulated, thermostatics does not include boundary conditions. Devices require boundary conditions to define their input and output. They usually involve flow and friction. Thermostatics is an unsuitable foundation for understanding technological and biological devices. A time dependent generalization of thermostatics that might be called thermal dynamics is being developed by Chun Liu and collaborators to avoid these limitations. Electrodynamics is not restricted like thermostatics, but in its classical formulation involves drastic assumptions about polarization and an over-approximated dielectric constant. Once the Maxwell equations are rewritten without a dielectric constant, they are universal and exact. Conservation of total current, including displacement current, is a restatement of the Maxwell equations that leads to dramatic simplifications in the understanding of one dimensional systems, particularly those without branches, like the ion channel proteins of biological membranes and the two terminal devices of electronic systems. The Brownian fluctuations of concentrations and fluxes of ions become the spatially independent total current, because the displacement current acts as an unavoidable low pass filter, a consequence of the Maxwell equations for any material polarization. Electrodynamics and thermal dynamics together form a suitable foundation for models of technological and biological systems.
A Measurement of Shipbuilding Productivity
Authors: Roque Paulo Z. , Gordo José Manuel
Published: September 2020

The present work studies the concept of productivity in shipbuilding and how it should be measured. The existing metrics, shipbuilding process and shipyard organization were studies in order to choose the most adequate metrics which would allow the measuring of a shipyard productivity in a systematic and holistic way. This is achieved by gathering the man-hours spent in each ship organized by cost centre and using Compensated Gross Tonnages as the measure of output from the shipyard. Data was gathered for thirty ships built in the same European yard organized by cost centre. From the data collected it was found that the ratio of hours spent in outfitting to the hours spent in structures is proportional to the complexity of the ship. There was also opportunity to study the work reduction resulting from building ships in series and the shares of labour for ships series and across ship types.