bluuebunny/crossref_metadata_2025 huggingface dataset:
The development of Ambulation Independence Measure: A new measurement tool to assess gait ability in acute stroke patients
Authors: Hayashi Yusuke , Yamazaki Kota , Takeda Kouichi , Ueda Shujiro , Mikawa Saiko , Hatori Kozo , Honaga Kaoru , Takakura Tomokazu , Hayashi Akito , Fujiwara Toshiyuki
Published: January 2022

BACKGROUND: The assessment of gait function is important for stroke rehabilitation. Gait function of patients with stroke often depends on the type of orthosis. There are however few gait assessments that assess the type of orthosis. OBJECTIVE: The purpose of this study was to investigate the reliability and validity of our newly developed Ambulation Independence Measure (AIM), which assesses the gait function, type of orthoses and physical assistance, for acute stroke patients. METHODS: A total of 73 acute stroke patients participated in this prospective study. The AIM discriminates 7 levels of gait ability on the basis of the amount of physical assistance required and orthoses that are used during walking. Interrater reliability, concurrent validity with the Functional Ambulation Category (FAC) and predictive validity were examined. RESULTS: The weighted kappas of AIM at the start of gait training (baseline) and discharge were 0.990 and 0.978, respectively. The AIM scores were significantly correlated with the FAC scores at both baseline (r = 0.808) and discharge (r = 0.934). Multiple regression analyses showed that the AIM at baseline was a stronger predictor of the FAC at discharge (R2 = 0.80). CONCLUSIONS: The AIM has excellent reliability, concurrent validity, predictive validity, and good responsiveness in acute stroke patients.
Question answering with deep neural networks for semi-structured heterogeneous genealogical knowledge graphs
Authors: Suissa Omri , Zhitomirsky-Geffet Maayan , Elmalech Avshalom
Published: January 2022

With the rising popularity of user-generated genealogical family trees, new genealogical information systems have been developed. State-of-the-art natural question answering algorithms use deep neural network (DNN) architecture based on self-attention networks. However, some of these models use sequence-based inputs and are not suitable to work with graph-based structure, while graph-based DNN models rely on high levels of comprehensiveness of knowledge graphs that is nonexistent in the genealogical domain. Moreover, these supervised DNN models require training datasets that are absent in the genealogical domain. This study proposes an end-to-end approach for question answering using genealogical family trees by: (1) representing genealogical data as knowledge graphs, (2) converting them to texts, (3) combining them with unstructured texts, and (4) training a transformer-based question answering model. To evaluate the need for a dedicated approach, a comparison between the fine-tuned model (Uncle-BERT) trained on the auto-generated genealogical dataset and state-of-the-art question-answering models was performed. The findings indicate that there are significant differences between answering genealogical questions and open-domain questions. Moreover, the proposed methodology reduces complexity while increasing accuracy and may have practical implications for genealogical research and real-world projects, making genealogical data accessible to experts as well as the general public.
Pengaruh Budaya, Sosial, Pribadi dan Psikologis Terhadap Keputusan Pembelian Durian Dengan Sistem Ijon
Authors: Adinugraha Hendri Hermawan , Fikri Muhammad Khoirul , Sukirno Sukirno
Published: January 2022

Cultural, social, personal, and psychological are consumer behavior factors in buying and selling transactions, especially buying and selling durian using the bonded bond system in Lemahabang Village. In practice, buying and selling of durian using the bonded system is carried out by both parties when the fruit is still on the tree, so the quality and quantity are not known. The purpose of this study was to determine how much cultural, social, personal, and psychology influence the purchase decision for durian with the bonded system. This study uses multiple linear regression analysis using the SPSS program. The population in this study were all durian farmers who were durian buyers with the bonded bond system in Lemahabang Village whose numbers were unknown or infinite. The sampling technique uses incidental sampling and the determination of the number of samples using the Lemeshow formula, which is a total of at least 100 samples. The data collection method used a questionnaire. The results showed that partially cultural, social, personal, and psychological factors had a significant and positive effect and positive relationship between the independent variables on durian purchasing decisions with the bonded system. Simultaneously, culture, social, personal, and psychological factors influence on durian purchasing decisions with the results of f count of 45.106> f table of 2.47 and a significant value of 0.000 <0.05.
Analisis Kritis Eksistensi Bunga Bank Sebagai Riba Keuangan Kontemporer
Authors: Hidayatullah Muhammad Syarif
Published: January 2022

Kajian ini dilatarbelakangi bahwa eksistensi bunga bank dalam perekonomian modern merupakan perwujudan riba di lembaga keuangan. Tulisan ini bertujuan untuk menelaah secara kritis praktik pembungaan uang dan eksistensi bunga bank sebagai riba keuangan kontemporer dari berbagai perspektif termasuk tinjauan hukum Islam. Selain itu juga tulisan ini berupaya menanggapi pendapat-pendapat yang dijadikan landasan dalam upaya melegalkan bunga bank. Bunga bank adalah perwujudan riba kontemporer dalam operasional bisnis modern dan salah satu yang menjadikannya pusat keuntungan dalam bisnisnya adalah bank konvensional. Dengan menggunakan metode qiyas dalam istinbat al-hukm bunga bank, maka praktik riba sebagai ashl dan bunga bank sebagai far’, keduanya disatukan dalam ‘illat yang sama yaitu adanya tambahan tanpa disertai imbalan. Karena itu keharaman riba berlaku pada hukum bunga bank. Praktik bunga bank inipun menyalahi kaidah al-ghurmu bi al-ghunmi dan al-kharaj bi adh-dhamân serta menjadi representasi prinsip time value of money (sistem ekonomi kapitalis). Ketetapan tentang keharaman bunga bank juga telah banyak dikeluarkan oleh berbagai forum ulama baik yang bertaraf nasional maupun internasional.
Concepciones docentes acerca de la participación de niñas, niños y adolescentes
Authors: Ochoa Cervantes Azucena
Published: January 2022

Los discursos y prácticas docentes están organizadas mediante estructuras de participación a través de las cuales se desarrolla la enseñanza y la socialización. Diversos estudios muestran que las concepciones docentes influyen en sus prácticas. Consideramos importante analizar las concepciones docentes acerca de la participación del alumnado debido a su impacto en la formación ciudadana. Se realizó un estudio cualitativo en el cual se analizó el discurso de 30 docentes y 4 directivos de primaria y secundaria en relación a las prácticas para promover la participación del alumnado. Los resultados indican que la concepción de participación y sus prácticas son rígidas, limitadas a actividades en el aula, y el lenguaje oral es el medio privilegiado para que se realice, lo cual no permite la creación de un clima propicio para que el alumnado desarrolle las habilidades necesarias para participar, limitando así el ejercicio de su ciudadanía.
Pomoc państwa w obliczu COVID-19 na przykładzie instrumentów wykorzystywanych w Polsce
Authors: Werner Aleksander
Published: January 2022

Celem artykułu jest przedstawienie instrumentów pomocy państwa wykorzystywanych w trakcie pandemii COVID-19, a także opis ogólnych regulacji dotyczących dopuszczalności udzielania pomocy państwa, w tym zapisów prawa pierwotnego i wtórnego oraz orzecznictwa Trybunału Sprawiedliwości Unii Europejskiej. Dodatkowo w artykule przedstawiono regulacje prawa miękkiego dotyczące dopuszczalności udzielania pomocy państwa (tymczasowe ramy) oraz opisano polskie programy pomocowe dla przedsiębiorstw dotkniętych skutkami pandemii koronawirusa. W końcu artykułu odniesiono się do rodzajów wykorzystywanych instrumentów pomocowych oraz wyboru wspieranych sektorów. Badania wykazały ograniczone wykorzystanie instrumentów podatkowych, a także dosyć dużą koncentrację wśród podmiotów udzielających pomocy (centralna administracja rządowa i agencje rządowe). Wybór sektorów wspieranych nie miał charakteru zaplanowanego programu gospodarczego.
Okul Öncesi Dönemde Çocuğu Satranç Eğitimi Alan Ebeveynlerin Satranç Eğitimine İlişkin Görüşleri
Authors: Kaplan Ebru , Kesicioğlu Oğuz Serdar , Aydın Sırma
Published: January 2022

Araştırmada okul öncesi dönemde çocuğu satranç eğitimi alan ebeveynlerin satranç eğitimine ilişkin görüşlerinin ortaya çıkarılması amaçlanmıştır. Bu araştırmada nitel araştırma desenlerinden durum çalışması kullanılmıştır. Araştırmanın çalışma grubunu çocuğu okul öncesi eğitimine devam eden toplam 118 ebeveyn oluşturmaktadır. Çalışma grubunun oluşturulmasında amaçlı örnekleme yöntemlerinden ölçüt örnekleme tekniği tercih edilmiştir. Araştırmanın verilerinin toplanması için açık uçlu anket sorularından yararlanılmıştır. Katılımcılarla yapılan görüşmelerin yüz yüze olması planlanmış, ancak pandemi nedeniyle veriler üç araştırmacı tarafından çevrimiçi ortamda oluşturulan formların her bir katılımcıya ulaştırılması yoluyla toplanmıştır. Araştırmada katılımcılardan elde edilen veriler içerik analizi yöntemiyle analiz edilmiştir. Araştırma sonuçları incelendiğinde ebeveynlerin okul öncesi dönemde satranç eğitimi alan çocuklarının alternatif düşünme becerilerine, dikkat/odaklanma süresine, planlama/strateji becerisine, matematiksel düşünme becerisine, neden-sonuç ilişkisi kurmasına katkı sağlayarak akademik becerilerini arttırdığını söyledikleri görülmektedir.
Öğretmenlerin Sınıf İçi Gündelik Deneyimleri: Fenomenolojik Bir Çalışma
Authors: Selvitopu Abdullah , Köroğlu Gülşen
Published: January 2022

Bu çalışmanın amacı öğretmenlerin sınıf içi gündelik deneyimlerini irdelemek ve söz konusu deneyimleri nasıl anlamlandırdıklarını ortaya çıkarmaktır. Bu amaç doğrultusunda öğrencilerle olan iletişim ve etkileşim, sınıf yönetimi süreçleri ve öğrenme ortamına ilişkin öğretmenlerin sınıf içi gündelik deneyimleri irdelenmiştir. Araştırmada nitel araştırma desenlerinden fenomonoloji deseni; verilerin toplanıp işlenmesi için yarı yapılandırılmış görüşme formu ve içerik analizi teknikleri kullanılmıştır. Çalışma grubu kamu okullarında görev yapan 5 öğretmenden oluşmaktadır. Çalışma grubunun belirlenmesi için amaçlı örnekleme yöntemi kullanılmıştır. Toplanan veriler içerik analizi ile analiz edilmiş; öğretmenlerin sınıf içi gündelik deneyimlerine ilişkin düşünceleri tespit edilmiştir. Yapılan analizler sonucunda öğretmenlerin sınıf içi gündelik deneyimlerinde, olumlu sınıf ikliminin oluşmasında öğrencilerle olan iletişim ve etkileşime önemli ölçüde vurgu yapmışlar ve sınıf içi otorite kurmanın sınıf yönetimiyle yakından ilgili olduğunu belirtmişlerdir. Bunun yanı sıra katılımcılar, öğretmen öğrenci arasındaki mesafenin ilişkileri şekillendirici bir özelliğe sahip olduğunu ve istenmeyen öğrenci davranışlarına yönelik öğretmen müdahalesinin sınırlı düzeyde olduğunu vurgulamışlardır. Buna ek olarak, öğrenciyle kurulan sağlıklı iletişimin öğrencinin kendini ifade edebilme becerisini geliştirdiği, öğretmenlerle öğrenciler arasında oluşturulan mesafenin karşılıklı saygıyı oluşturduğu ve olumlu sınıf ikliminin ortaya çıkmasına katkı sağladığı söylenebilir.
TURKEY'S BRAND VALUE AND COUNTRY IMAGE IN THE EYES OF AZERBAIJAN BEFORE AND AFTER THE RECENT AZERBAIJAN ARMENIA WAR
Authors: GÖKTAŞ Bora , ERDOĞAN TARAKÇI İnci , BAŞ Mehmet
Published: January 2022

The concept of brand continues to show its function in different areas and increase its importance day by day. Especially in the intense global competition environment, branding has moved from the dimension of products to a dimension between cities and countries. A strong country brand reflects on the products produced by the country, on the other hand, it increases the reputation of the country and enables it to have more say in the international political arena and to become a centre of attraction for investors by increasing their income. In this study, it is aimed to be determined whether Turkey's brand value and country image in the eyes of the brother country Azerbaijan has been changed or not as a result of the support given to Azerbaijan by Turkey in the recent Azerbaijan-Armenia war. For this purpose, the first period of the study in September 2020, and the second period after the war between December 2020 and January 2021, was carried out by conducting an online survey throughout Azerbaijan with Azerbaijani Turks living in Azerbaijan. Study findings reveal the brand value and country image of Turkey before and after the war in the eyes of Azerbaijani Turks living in Azerbaijan in dimensions of sincerity, excitement, competence, sophistication and ruggedness.
PANDEMİ GÖLGESİNDE BREXİT: BİRLEŞİK KRALLIK VE AVRUPA BİRLİĞİ EKONOMİLERİNE ETKİLERİ
Authors: KESKİN Musa
Published: January 2022

Birleşik Krallık (BK)’ın Avrupa Birliğinden (AB) ayrılmasını nitelendirmek için kullanılan Brexit kavramı, siyasi etkilerinden daha çok yaratacağı ekonomik etkilerle tartışılmaktadır. Bu çalışmada taraflar arasında yürütülen müzakerelerde gündeme gelen çeşitli Brexit senaryoları ve anlaşmanın yapılmasıyla birlikte BK ve AB’de görülen ekonomik etkiler değerlendirilmiştir. Tüm senaryolarda çıkan ortak sonuç, Brexit’in hem BK hem de AB ekonomisini olumsuz etkileyeceği ancak BK ekonomisine olan olumsuz etkisinin AB ekonomisinde yaratacağı olumsuz etkiden daha fazla olacağı yönünde olmuştur. Çalışmada bu etkiler; Gayri Safi Yurt İçi Hasıla (GSYİH), Kişi Başına Düşen Milli Gelir, Dış Ticaret ve Doğrudan Yabancı Yatırımlar açısından analiz edilmiştir. Müzakereler sonunda BK ve AB arasında imzalanan Serbest Ticaret Anlaşmasının yürürlüğe girmesiyle birlikte dış ticarette büyük aksamalar ve düşüşler meydana gelmiştir. Ayrıca anlaşmanın ilk aylarında özellikle BK’nın GSYİH oranında azalma meydana gelirken AB’nin BK’daki yatırım oranında ve emek göçünde de düşüşler yaşanmıştır. Ancak 2020 yılı başında başlayan ve Büyük Buhrandan sonra görülen en büyük ekonomik kriz olarak nitelendirilen Covid-19 pandemisi, Brexit’in yarattığı olumsuz ekonomik etkilerin tam olarak tespit edilmesini zorlaştırmaktadır. Bu yüzden Brexit’in ekonomik etkilerinin uzun vadede daha net bir şekilde ortaya çıkacağı tahmin edilmektedir.
TÜRKİYE’DE BUĞDAY ÜRETİM SEKTÖRÜNÜN YAPISI VE ARIMA MODELİ İLE ÜRETİM TAHMİNİ
Authors: AYDIN Atilla
Published: January 2022

Buğday, insanlar için en temel besin kaynağıdır. Bu nedenle tüm dünyada buğday üretimi önemsenmekte, buğday üretimine ilişkin iktisadi politikalar üretilmektedir. Buğdayın talep esnekliği düşük olduğundan buğday fiyatları, arz tarafından belirlenmektedir. Buğday arzı, iklim koşullarından da etkilendiği için ülkelerin buğday üretimi yıldan yıla değişiklik gösterebilmekte ve bu nedenle uluslararası buğday ticareti önem kazanmaktadır. Türkiye, uluslararası buğday piyasasında net ithalatçı konumundadır ve bunun doğal sonucu olarak buğdayı girdi olarak kullanan sektörler, döviz kurlarındaki dalgalanmalardan etkilenmektedir. Bu çalışmada Türkiye’nin gelecekteki beş yıllık dönemdeki buğday üretiminin tahmini yapılmıştır. ARIMA modelinin kullanıldığı çalışmada gelecek beş yıllık dönemde sınırlı bir artış öngörülmüştür. Ayrıca buğday üretiminde arz artışını sağlayacak politikalar üzerinde durulmuş, çözüm önerileri getirilmiştir.
Venous Thromboembolic Diseases: Epidemiological, Clinical, Para clinical, Therapeutic and Evolutionary Aspects: Retrospective Study over a Period of 7.5 Years about 112 Cases collected in the Internal Medicine and Cardiology Department of Lnth
Authors: AI Toure , K Souley , A Boncano , B Dodo , M Hangar , S Haggar , À Zakaria , S Djonyony
Published: January 2022

Introduction: venous thromboembolism (VTE) is a real public health problem in the world due to its frequency and severity since the mortality from an untreated thromboembolic episode is around 30%. Because of its chronic and disabling complications (post-thrombotic disease and chronic thromboembolic pulmonary hypertension), it is responsible for a deterioration in the quality of life of patients. Objective: The aim of this work was to contribute to the study of the epidemiological , clinical, Para clinical, therapeutic and evolutive aspects of venous thromboembolism disease in the internal medicine and cardiology department of the Amirou Boubacar Diallo National Hospital. Patients and Methods: It's a prospective study from July 1st, 2019 to June 30th, 2020 and retrospective from January 1st, 2013 to June 30th, 2019 (7 years and 6 months) about 112 patients with whom the diagnostic of deep venous thrombosis (DVT ) and / or pulmonary embolism (PE) had been done. Results: In our study, the prevalence of venous thromboembolism has been estimated at 3.9% of hospitalized patients with cardiovascular diseases. There was a female predominance (sex ratio 1.38). The average age of patients was 52 years. Teabed-rest prolonged was the frequent risk factor (66%). The clinical symptomatology was dominated by oedema of the lower limb (83.3%) and pain in limb palpation (82.1%) in case of DVT, the dyspnea (23.02%) and thoracic pain (11.6%) in case of PE. The attack of the left lower limb prevailed (45.5%). The sinus tachycardia (25.9%) was the predominant electrical sign at the ECG. Through the Doppler of the lower limbs, the popliteal and femoral veins were the most involved with 22.3% and 17.8% respectively. According to the chest angio-CT, the left pulmonary artery was obstructed in 100% of case. The treatment was essentially made of low molecular weight heparins (90.1%) replaced quickly by vitamin k antagonist (began the first day of the heparin therapy) and / or of unfractionated heparin (9%). The most common complication was PE due to DVT and the overall mortality was 12.5%. Conclusion: VTE is pathology in young adults and elderly characterized by the formation of a clot in a vein responsible for the obstruction of the latter causing local inflammatory signs and / or its pulmonary migration which could be fatal. The prevention and treatment of VTE are based on anticoagulants.
Epidemiology of Sudden Cardiac Death: Necropsic Studies at Aristide Le Dantec Hospital
Authors: M Bodian , SCG Akanni , SM Beye , JS Mingou , Y Diouf , AD Niass , F Aw , SA Sarr , CMBM Diop , PG Ndiaye , AA Ngaïdé , M Dioum , M Lèye , U Ralaizandry , MB Ndiaye , A Mbaye , AD Kane , A Kane , M Diao
Published: January 2022

Introduction: Sudden cardiac death (SCD) remains a major public health issue. In Senegal, there is a lack of data on this phenomenon; this underlies the relevance of this study whose objective is to study the epidemiological profile of victims experiencing unrecovered sudden cardiac arrest at Aristide LE DANTEC Hospital. Patients and Methods: This is a transverse study with retrospective data collection from January 1, 2016 to January 31, 2017. Included, in the study were all victims of sudden cardiac death in Dakar who had a necropsy in the morgues of Aristide Le Dantec Hospital. Results: We recorded 69 cases of sudden death of cardiovascular origin from 169 forensic autopsy reports, or 40.8% of autopsies. The average age was 44 years with a male predominance in 76.81%. The large majority of death occurred at home (26%), without witnesses (48%) and at rest (36%). Two cases of sudden death, or 3%, occurred at exertion. These deaths were recorded in 16% of cases in the middle of the day. The highest death rate was recorded during the month of December (15.9%). Malaise was the predominant symptom (13%) followed by emotional stress (6%). The existence of a history could only be clarified in 4% of cases. The electrocardiogram was only performed in 1 case. At necropsy, ischemic heart disease was the leading disease (46%), 26% of which was due to myocardial infarction, followed by hypertrophic cardiomyopathy (16%) and mixed cardiomyopathy (13%). Tamponade, dilated cardiomyopathy and aortic dissection were found in 9%, 6% and 4% of cases, respectively. Conclusion: Sudden cardiac death is a major public health problem. In the Senegalese population, victims of unrecovered SCD are relatively young with a predominance of men. Coronary artery disease is the most frequently implicated pathology. Faced with this observation, a national program for the integrated control of cardiovascular risk factors is necessary.
Special Education Teachers in Residence
Authors: Bock Marj , Caballero Mari , O'Neal-Hixson Kelly
Published: January 2022

Rural schools face unique challenges recruiting teachers. Rural school administrators report difficulties finding qualified applicants. Unique challenges rural special education teachers face, e.g., working with a more diverse group of students including those with significant disabilities, heighten the difficulties rural administrators experience when recruiting and retaining qualified special education teachers. Leveraging university/rural school partnerships, e.g., resident teacher university/school partnerships, can help rural schools recruit and retain qualified special education teachers. This article describes the Teachers College Special Education Fellowship Program (TCSEFP), a virtual residency in teaching program. This program established virtual partnerships between the university and numerous rural school districts throughout the state. The article includes a description of the program, evaluation data, and implications for other virtual university/school residency in teaching programs.
Interpretation of Tourist Attracion in Japanese Language at Penglipuran Village, Bali
Authors: Renold Renold , Marannu Eppang Buntu , Wijaya Darsyaf Hadi , Usman Ode
Published: January 2022

Penelitian ini bertujuan untuk: (1) untuk mengetahui interpretasi personal dalam bahasa Jepang oleh pemandu wisata pada daya tarik wisata desa Penglipuran dan (2) untuk mengetahui penerapan interpretasi non personal dalam bahasa Jepang oleh pemandu wisata pada daya tarik wisata desa Penglipuran. Pengumpulan data dari penelitian ini diambil dengan teknik: wawancara, dokumentasi dan observasi serta analisis data dilakukan dengan metode deskriptif kualitatif.

Hasil dari penelitian ini menunjukan bahwa pemandu wisata wisatawan Jepang yang melakukan pemanduan khususnya dalam bahasa Jepang di kawasan daya tarik wisata desa Penglipuran sudah maksimal kepada setiap wisatawan yang berkunjung di kawasan desa Penglipuran dengan melakukan persiapan seperti menyiapkan alat bantu seperti bendera, pengeras suara dan sebagainya sebelum melakukan pemanduan dan hingga pada proses memberikan pelayanan dalam memberikan informasi kepada wisatawan yang bertujuan untuk menciptakan kesan yang baik terhadap setiap wisatawan yang berkunjung dan agar wisatawan yang berkunjung bisa mendapatkan informasi dan pemahaman yang baik terhadap desa Penglipuran. Dalam memberikan informasi maupun interpretasi, pemandu wisata menggunakan teknik yang disebut dengan TORE (Thematic, Organized, Relevant, Enjoyable). Pemandu wisata menggunakan gestur ketika ada kesulitan menerjemahakan dalam bahsa jepang padanan kosa katanya hal ini bertujuan agar program interpretasi bisa berjalan dengan baik dan menyenangkan. Penerapan dan pemanfaatan media interpretasi non personal yang telah tersedia di desa Penglipuran oleh pemandu wisata asing Jepang sudah sangat baik hal ini dapat dilihat dari beberapa papan nama situs sudah terintegrasi dengan informasi yang diakses secara digital. Terdapat pula papan rambu yang tertulis dalam bahsa Jepang.

 

KEY WORDS:  Bahasa Jepang, Interpretasi, Personal, Non Personal
Using Wastewater for Agriculture in Faisalabad: Appraisal of Socio-Cultural and Economic Outcomes
Authors: Nawaz Waseem , Sher Falak , Batool Zahira , Musa Muhammad , Mahmood Sadaf
Published: January 2022

The urban slums deprived of basic human needs like drinking water, and sanitation facilities are spreading in major cities like Faisalabad, Karachi, and Lahore. The wastewater generated in houses and foul water of rain is being thrown away directly into open channels or in covered sewers. The wastewater collected at disposal stations either after treatment or as such is being used for agriculture purposes by farmers placed in surrounding villages. The reuse of wastewater for agriculture is influencing the physical ecosystem as well as cultural and socio-economic situations of the community. The study was carried out to appraise cultural and socio-economic outcomes of using wastewater for agriculture in Department of Sociology, Government College University Faisalabad during January-March 2020. The data were collected both from primary and secondary sources. Certain transact walks in area of the study were made and consultative meetings with key informants were also held. 60 farmers who were using wastewater for agriculture, were selected by simple random sampling techniques. The appraisal of data revealed that reuse of wastewater for agriculture activities had positive impacts on cultural and socio-economic aspects of the rural community. The results indicated that reuse of wastewater for agriculture activities had many positive impacts on cultural and socio-economic aspects of the rural population. Price of agricultural land, rent of land, and households’ monthly income were increased. Employment opportunities were also generated. The perception of community about most of the environmental improvement was better. However, perception of farmers about impact on public health, soil structure and groundwater resources were medium or low.  It is also concluded that use of wastewater for agriculture is a beneficial source of plant nutrients and organic matter required for retaining the richness and output levels of soil that enhance living standards of inhabitants and lessen poverty.
Framing Media Tentang Influencer Sebagai Jaringan Informasi Pemerintah
Authors: Salsabila Shelma , Kusumastuti Frida
Published: January 2022

News framing about influencers, it is known how the mass media fight for their interests. The study analyzed three news stories about government influencers from three different media during the period of August 2020. The study used a qualitative approach with the Pan & Kosicki framing analysis method. The results show that Republika.co.id's framing emphasizes on finding data that causes debate. While Detik.com's framing directs the existence of influencers as corruption events, and Kompas.com's framing provides an overview of influencers who have a strong position as an information network because they are key opinion leaders in the digital era.
Paraplegic women’s emancipation along their vocational pathways: the potential contributions of Freirean, structural and post-structural feminist pedagogies
Authors: Pont Elena , Collet Isabelle
Published: January 2022

We have recently completed doctoral research on the reconstruction of paraplegic men’s and women’s vocational trajectories in French-speaking Switzerland. Based on three female informants’ life narratives, we analyse issues of gendered vocational guidance, pathways and identities in paraplegic people’s life courses. We shape some emancipating experience models and discourses about action, which empower the female informants on their vocational pathways. Our objective is here to point to the potential support that an emancipatory, feminist pedagogical approach could offer paraplegic women in the further development of personal models, and discourses of self in the conduct of their educational and vocational life.
Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer
Authors: Peng Yun , Song Yuxuan , Wang Haitao
Published: January 2022

Aneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa about the effects of aneuploidy on different omics and, especially, about the driver genes of aneuploidy. Here, we validated the association of aneuploidy with the progression and prognosis of PCa and performed a systematic analysis in mutation profile, methylation profile, and gene expression profile, which detailed the molecular process aneuploidy implicated. By multi-omics analysis, we managed to identify 11 potential aneuploidy driver genes (GSTM2, HAAO, C2orf88, CYP27A1, FAXDC2, HFE, C8orf88, GSTP1, EFS, HIF3A, and WFDC2), all of which were related to the development and metastasis of PCa. Meanwhile, we also found aneuploidy and its driver genes were correlated with the immune microenvironment of PCa. Our findings could shed light on the tumorigenesis of PCa and provide a better understanding of the development and metastasis of PCa; additionally, the driver genes could be promising and actionable therapeutic targets pointing to aneuploidy.
Arginylation Regulates G-protein Signaling in the Retina
Authors: Fina Marie E. , Wang Junling , Vedula Pavan , Tang Hsin-Yao , Kashina Anna , Dong Dawei W.
Published: January 2022

Arginylation is a post-translational modification mediated by the arginyltransferase (Ate1). We recently showed that conditional deletion of Ate1 in the nervous system leads to increased light-evoked response sensitivities of ON-bipolar cells in the retina, indicating that arginylation regulates the G-protein signaling complexes of those neurons and/or photoreceptors. However, none of the key players in the signaling pathway were previously shown to be arginylated. Here we show that Gαt1, Gβ1, RGS6, and RGS7 are arginylated in the retina and RGS6 and RGS7 protein levels are elevated in Ate1 knockout, suggesting that arginylation plays a direct role in regulating their protein level and the G-protein-mediated responses in the retina.
Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications
Authors: Sun Yuyang , Wan Ben , Wang Renxian , Zhang Bowen , Luo Peng , Wang Diaodiao , Nie Jing-Jun , Chen Dafu , Wu Xinbao
Published: January 2022

Treatment of bone defects remains a challenge in the clinic. Artificial bone grafts are the most promising alternative to autologous bone grafting. However, one of the limiting factors of artificial bone grafts is the limited means of regulating stem cell differentiation during bone regeneration. As a weight-bearing organ, bone is in a continuous mechanical environment. External mechanical force, a type of biophysical stimulation, plays an essential role in bone regeneration. It is generally accepted that osteocytes are mechanosensitive cells in bone. However, recent studies have shown that mesenchymal stem cells (MSCs) can also respond to mechanical signals. This article reviews the mechanotransduction mechanisms of MSCs, the regulation of mechanical stimulation on microenvironments surrounding MSCs by modulating the immune response, angiogenesis and osteogenesis, and the application of mechanical stimulation of MSCs in bone regeneration. The review provides a deep and extensive understanding of mechanical stimulation mechanisms, and prospects feasible designs of biomaterials for bone regeneration and the potential clinical applications of mechanical stimulation.
Ocular Effects of Glycyrrhizin at Acidic and Neutral pH
Authors: Somayajulu Mallika , McClellan Sharon A. , Bessert Denise A. , Pitchaikannu Ahalya , Hazlett Linda D.
Published: January 2022

Purpose

To test the effects of acidic vs. neutral pH glycyrrhizin (GLY) on the unwounded and wounded normal mouse cornea and after infection with Pseudomonas aeruginosa isolates KEI 1025 and multidrug-resistant MDR9.

Methods

Acidic or neutral GLY vs. phosphate-buffered saline (PBS) was topically applied to normal or wounded corneas of C57BL/6 mice. In unwounded corneas, goblet cells and corneal nerves were stained and quantitated. After wounding, corneas were fluorescein stained and photographed using a slit lamp. Mice also were infected with KEI 1025 or MDR9 and the protective effects of GLY pH evaluated comparatively.

Results

In the unwounded cornea, application of acidic or neutral GLY vs. PBS reduced the number of bulbar conjunctival goblet cells but did not alter corneal nerve density. Similar application of GLY to scarified corneas delayed wound closure. After KEI 1025 infection, none of the GLY vs. PBS-treated corneas perforated; GLY treatment also decreased plate count (neutral pH more effective) and reduced MPO and several cytokines. Similarly, for MDR9, GLY at either pH was protective and also enhanced the effects of moxifloxacin to which MDR9 is resistant.

Conclusion

Acidic or neutral pH GLY decreased goblet cell number but had no effect on nerve density. After corneal wounding, GLY at either pH (1) delayed wound closure and, (2) after infection, decreased keratitis when used alone or in combination with moxifloxacin. Neutral pH did not alter the therapeutic effect of GLY and would be preferred if used clinically.
Probiotics: Potential Novel Therapeutics Against Fungal Infections
Authors: Wu Yunjian , Hu Shan , Wu Changyu , Gu Feng , Yang Ying
Published: January 2022

The global infection rate of fungal diseases is increasing year by year, and it has gradually become one of the most serious infectious diseases threatening human health. However, the side effects of antifungal drugs and the fungal resistance to these drugs are gradually increasing. Therefore, the development of new broad-spectrum, safe, and economical alternatives to antibacterial drugs are essential. Probiotics are microorganisms that are beneficial for human health. They boost human immunity, resist pathogen colonization, and reduce pathogen infection. Many investigations have shown their inhibitory activity on a wide range of pathogenic fungi. However, their antibacterial mechanism is still a secret. This article reviews the progress of probiotics as a new method for the treatment of fungal diseases.
Outcomes Following Percutaneous Coronary Intervention in Saphenous Vein Grafts With and Without Embolic Protection Devices: A Systematic Review and Meta-Analysis
Authors: Yu Jianhong , Zhang Jianhai , Ni Jianchao , Shou Weiqing , Fang Yuanyuan , Fu Suna
Published: January 2022

Objective

This study aimed to review studies comparing outcomes following percutaneous coronary intervention (PCI) in saphenous vein grafts (SVG) with and without embolic protection devices (EPD).

Methods

Databases including PubMed Central, Cochrane Library, EMBASE, CINAHL, MEDLINE, Google Scholar, ScienceDirect, and Scopus were searched from January 1964 to April 2021. We used the Cochrane risk of bias tool and the Newcastle Ottawa scale to assess the quality of published studies based on study design. From the results, we carried out a meta-analysis with a random-effects model and reported pooled odds ratio (OR) with 95% CI.

Results

In total, 11 studies were analyzed that included 79,009 total participants. EPD use had significantly lower odds of mortality (pooled OR = 0.69; 95% CI: 0.5–0.94). There was no significant difference in terms of major adverse cardiovascular events (MACE) (pooled OR = 0.83; 95% CI: 0.67–1.03), target vessel revascularization (pooled OR = 1; 95% CI: 0.95–1.05), periprocedural (pooled OR = 1.12; 95% CI: 0.65–1.9) and late myocardial infarction (MI) (pooled OR = 0.79; 95% CI: 0.55–1.14) with or without EPD for PCI in SVG patients.

Conclusion

Although not statistically beneficial for MACE, target vessel revascularization, periprocedural, and late MI, EPD use does appear to significantly reduce mortality for the patients undergoing PCI in SVG. Clinicians might consider using EPD for such patients to reduce the burden of post-procedural morbidity and mortality.
Pregnancy Complications and Outcomes Among Women With Congenital Heart Disease in Beijing, China
Authors: Liu Yang , Li Yanna , Zhang Jun , Zhao Wenjuan , Bao Zhaoliang , Ma Xiaolong , Zhao Yichen , Zhao Cheng , Liu Kemin , Ye Qing , Su Lixiao , Yang Yao , Yang Jing , Li Gang , Fan Xiangming , Wang Jiangang
Published: January 2022

Objective

To conduct a comparative analysis of the complications and outcomes in pregnant women with and without congenital heart disease (CHD) in Beijing, China.

Methods

We compared pregnancy-related complications and outcomes experienced by women with and without CHD throughout 19,424 deliveries in Beijing Anzhen Hospital between 2010 and 2019, including cardiovascular and obstetric factors, fetal events, delivery methods, and other complications over a mean 5-years post-delivery follow-up period.

Results

There were 1,040 women with CHD (5.35% of all deliveries). Compared to women without CHD, these women had longer hospital stays (7.83 ± 4.65 vs. 4.93 ± 3.26 days) and a higher death rate (1.92 vs. 0.02%). They also had a greater risk of comorbidities, including pre-term delivery (odds ratio: 13.65 vs. 6.71), heart failure (odds ratio: 4.90 vs. 0.40), and arrhythmia (odds ratio 12.69 vs. 4.69). Pulmonary hypertension, New York Heart Association functional class III~IV, and no congenital heart disease surgery prior to pregnancy were associated with adverse events such as cesarean section, pre-term delivery, and heart failure. The fetuses of mothers with CHD were more likely to be born pre-term (odds ratio: 13.65 vs. 6.71) and have low birth weight (odds ratio: 8.56 vs. 4.36). Eleven infants (1.82%) born to mothers with CHD and four infants (0.64%) born to mothers without CHD were diagnosed with CHD.

Conclusions

Women with CHD generally increase maternal and infant risk during pregnancy and the perinatal period. Pulmonary hypertension, decrease in cardiac function, and no previous CHD surgery increase the risk in women with CHD. Greater attention should be paid to pregnant women with CHD and their fetuses, newborns.
The Value of IGF-1 and IGFBP-1 in Patients With Heart Failure With Reduced, Mid-range, and Preserved Ejection Fraction
Authors: Guo Shaohua , Gong Mengqi , Tse Gary , Li Guangping , Chen Kang-Yin , Liu Tong
Published: January 2022

Background

Previous studies have reported inconsistent results regarding the implications of deranged insulin-like growth factor 1 (IGF-1)/insulin-like growth factor-binding protein 1 (IGFBP-1) axis in patients with heart failure (HF). This study evaluates the roles of IGF1/IGFBP-1 axis in patients with HF with reduced ejection fraction (HFrEF), mid-range ejection fraction (HFmrEF), or preserved ejection fraction (HFpEF).

Methods

Consecutive patients with HFrEF, HFmrEF, and HFpEF who underwent comprehensive cardiac assessment were included. The primary endpoint was the composite endpoint of all-cause death and HF rehospitalization at one year.

Results

A total of 151 patients with HF (HFrEF: n = 51; HFmrEF: n = 30; HFpEF: n = 70) and 50 control subjects were included. The concentrations of IGFBP-1 (p < 0.001) and IGFBP-1/IGF-1 ratio (p < 0.001) were significantly lower in patients with HF compared to controls and can readily distinguish patients with and without HF (IGFBP-1: areas under the curve (AUC): 0.725, p < 0.001; IGFBP-1/IGF-1 ratio: AUC:0.755, p < 0.001; respectively). The concentrations of IGF-1, IGFBP-1, and IGFBP-1/IGF-1 ratio were similar among HFpEF, HFmrEF, and HFrEF patients. IGFBP-1 and IGFBP-1/IGF-1 ratio positively correlated with N-terminal probrain natriuretic peptide (NT-proBNP) levels (r = 0.255, p = 0.002; r = 0.224, p = 0.007, respectively). IGF-1, IGFBP-1, and IGFBP-1/IGF-1 ratio did not predict the primary endpoint at 1 year for the whole patients with HF and HF subtypes on both univariable and multivariable Cox regression.

Conclusion

The concentrations of plasma IGFBP-1 and IGFBP-1/IGF-1 ratio can distinguish patients with and without HF. In HF, IGFBP-1 and IGFBP-1/IGF-1 ratio positively correlated with NT-proBNP levels.
The Prevalence and Associated Death of Ventricular Arrhythmia and Sudden Cardiac Death in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis
Authors: Tan Ziqi , Huang Shan , Mei Kaibo , Liu Menglu , Ma Jianyong , Jiang Yuan , Zhu Wengen , Yu Peng , Liu Xiao
Published: January 2022

Background

Arrhythmia is a very common complication of coronavirus disease 2019 (COVID-19); however, the prevalence of ventricular arrhythmia and associated outcomes are not well-explored. Here, we conducted a systematic review and meta-analysis to determine the prevalence and associated death of ventricular arrhythmia and sudden cardiac death (SCD) in patients with COVID-19.

Methods

Databases of PubMed, Cochrane Library, Embase, and MdeRxiv were searched. Studies that could calculate the prevalence of ventricular arrhythmia/SCD during hospital admission or associated death in patients with COVID-19 were included. The study was registered with the PROSPERO (CRD42021271328).

Results

A total of 21 studies with 13,790 patients were included. The pooled prevalence of ventricular arrhythmia was 5% (95% CI: 4–6%), with a relatively high-SCD prevalence (1.8% in hospitalized COVID-19 and 10% in deceased cases of COVID-19). Subgroup analysis showed that ventricular arrhythmia was more common in patients with elevated cardiac troponin T [ES (effect size): 10%, 95% CI: −0.2 to 22%] and in European (ES: 20%, 95% CI: 11–29%) populations. Besides, ventricular arrhythmia was independently associated with an increased risk of death in patients with COVID-19 [odds ratio (OR) = 2.83; 95% CI: 1.78–4.51].

Conclusion

Ventricular arrhythmia and SCD resulted as a common occurrence with a high prevalence in patients with COVID-19 admitted to the hospital. Furthermore, ventricular arrhythmia significantly contributed to an increased risk of death in hospitalized patients with COVID-19. Clinicians might be vigilant of ventricular arrhythmias for patients with COVID-19, especially for severe cases.

Systematic Review Registration

www.york.ac.uk/inst/crd, identifier: CRD42021271328.
Impact of Hypertension History and Blood Pressure at Presentation on Cardiac Remodeling and Mortality in Aortic Dissection
Authors: Oliveira Matheus F. R. A. , Rocha Walter E. M. , Soares Julia D. , L'Armée Victor M. F. S. , Martins Mayara P. G. , Rocha Aloísio M. , Feitosa Audes D. M. , Lima Ricardo C. , Oliveira Pedro P. M. , Silveira-Filho Lindemberg M. , Coelho-Filho Otavio R. , Matos-Souza José R. , Petrucci Orlando , Sposito Andrei C. , Nadruz Wilson
Published: January 2022

Objective

This study compared clinical, echocardiographic, and prognostic characteristics among patients with aortic dissection (AD) with (HypHist) and without (No-HypHist) hypertension history and evaluated the association of blood pressure (BP) at presentation with 1-year mortality, left ventricular (LV) remodeling and renal dysfunction.

Methods

We investigated clinical and echocardiographic characteristics and 1-year mortality among 367 patients with AD (81% HypHist, 66% Type-A) from three Brazilian centers.

Results

Patients with No-HypHist were more likely to have Marfan syndrome, bicuspid aortic valve, to undergo surgical therapy, were less likely to have LV hypertrophy and concentricity, and had similar mortality compared with HypHist patients. Adjusted restricted cubic spline analysis showed that systolic BP (SBP) and diastolic BP (DBP) at presentation had a J-curve association with mortality among patients with No-HypHist, but did not associate with death among patients with HypHist (p for interaction = 0.001 for SBP and = 0.022 for DBP). Conversely, the association between SBP at presentation and mortality was influenced by previous use of antihypertensive medications in the HypHist group (p for interaction = 0.002). Results of multivariable logistic regression analysis comprising the whole sample showed direct associations of SBP and DBP at presentation with LV hypertrophy (p = 0.009) and LV concentricity (p = 0.015), respectively, and an inverse association between pulse pressure at presentation and estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 (p = 0.008).

Conclusion

Combined information on BP at presentation, previous diagnosis of hypertension, and use of antihypertensive medications might be useful to predict mortality risk and to estimate extra-aortic end-organ damage among patients with AD.
Active Tectonics of the Nantinghe Fault in Southeastern Tibetan Plateau and its Implications for Continental Collision
Authors: Shi Feng , He Honglin , Liu Yiduo , Wei Zhanyu , Sun Haoyue
Published: January 2022

Quantifying the structure and kinematics of active faults is the key to understanding the India-Eurasia continental collision. While the boundary faults of blocks in the southeastern Tibetan Plateau region have been under scrutiny for decades, relatively less attention has been paid to the active faults within the blocks. Here, we use structural, sedimentary, and geomorphic characteristics to constrain the late Quaternary kinematics and slip rates of the Nantinghe fault, a major fault within the southeastern Tibetan Plateau region. The Nantinghe fault is an active, dominantly left-lateral strike-slip fault that can be traced continuously for 500 km. We analyze the late Quaternary slip rates at five sites along the fault trace. The latest Quaternary apparent throw rates are typically less than 1 mm/a. The rate of strike-slip displacement is estimated to be an order of magnitude higher, 4.0 ± 0.6 (2σ) mm/a. Trenching suggests that active fault behavior is dominated by strike-slip faulting and reveals five earthquake events with refined information of timing in the last 5,000 years, suggesting an averaged recurrence interval of ∼1,000 a. These observations agree with GPS-derived estimates and show that late Quaternary slip rates on the Nantinghe fault are comparable to those on other major active strike-slip faults in the southeastern Tibetan Plateau. The newly-obtained slip rates on the Nantinghe fault, integrated with previous estimates on other faults in this region, provide direct evidence that favors the continuum models over the rigid block ones, on the Quaternary deformation mechanism in the India-Asia continental collision.