bluuebunny/crossref_metadata_2025 huggingface dataset:
SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment
Authors: O’Connell Patrick , Hyslop Sean , Blake Maja K , Godbehere Sarah , Amalfitano Andrea , Aldhamen Yasser A
Published: December 2020

T cell exhaustion represents one of the most pervasive strategies tumors employ to circumvent the immune system. Although repetitive, cognate TCR signaling is recognized as the primary driving force behind this phenomenon, and it remains unknown what other forces drive T cell exhaustion in the tumor microenvironment (TME). In this study, we show that activation of the self-ligand SLAMF7 immune receptor on T cells induced STAT1 and STAT3 phosphorylation, expression of multiple inhibitory receptors, and transcription factors associated with T cell exhaustion. Analysis of The Cancer Genome Atlas revealed that SLAMF7 transcript levels were strongly correlated with various inhibitory receptors and that high SLAMF7 expression was indicative of poor survival in clear cell renal cell carcinoma (ccRCC). Targeted reanalysis of a CyTOF dataset, which profiled the TME in 73 ccRCC patients, revealed cell-type–specific SLAMF7 expression patterns, strong correlations between exhausted T cells and SLAMF7+ tumor-associated macrophages (TAMs), and a unique subset of SLAMF7highCD38high TAMs. These SLAMF7highCD38high TAMs showed the strongest correlations with exhausted T cells and were an independent prognostic factor in ccRCC. Confirmatory ex vivo coculture studies validated that SLAMF7–SLAMF7 interactions between murine TAMs and CD8+ T cells induce expression of multiple inhibitory receptors. Finally, mice lacking SLAMF7 show restricted growth of B16-F10 tumors, and CD8+ T cells from these mice express less PD-1 and TOX and exhibited an impaired ability to progress through the exhaustion developmental trajectory to terminal exhaustion. These findings suggest that SLAMF7 might play an important role in modulating T cell function in the TME.
Granzyme B Induces IRF-3 Phosphorylation through a Perforin-Independent Proteolysis-Dependent Signaling Cascade without Inducing Cell Death
Authors: Gapud Eric J , Trejo-Zambrano Maria Isabel , Gomez-Banuelos Eduardo , Tiniakou Eleni , Antiochos Brendan , Granville David J , Andrade Felipe , Casciola-Rosen Livia , Rosen Antony
Published: December 2020

Granzyme B (GrB) is an immune protease implicated in the pathogenesis of several human diseases. In the current model of GrB activity, perforin determines whether the downstream actions of GrB occur intracellularly or extracellularly, producing apoptotic cytotoxicity or nonapoptotic effects, respectively. In the current study, we demonstrate the existence of a broad range of GrB-dependent signaling activities that 1) do not require perforin, 2) occur intracellularly, and 3) for which cell death is not the dominant outcome. In the absence of perforin, we show that GrB enzymatic activity still induces substoichiometric activation of caspases, which through nonlethal DNA damage response signals then leads to activity-associated phosphorylation of IFN regulatory factor–3. These findings illustrate an unexpected potential interface between GrB and innate immunity separate from the traditional role of GrB in perforin-dependent GrB-mediated apoptosis that could have mechanistic implications for human disease.
Cutting Edge: NOX2 NADPH Oxidase Controls Infection by an Intracellular Bacterial Pathogen through Limiting the Type 1 IFN Response
Authors: Rojas Márquez Jorge David , Li Taoyingnan , McCluggage Adam R R , Tan Joel M J , Muise Aleixo , Higgins Darren E , Brumell John H
Published: December 2020

The NOX2 NADPH oxidase (NOX2) produces reactive oxygen species to kill phagosome-confined bacteria. However, we previously showed that Listeria monocytogenes is able to avoid the NOX2 activity in phagosomes and escape to the cytosol. Thus, despite the established role of NOX2 limiting L. monocytogenes infection in mice, the underlying mechanisms of this antibacterial activity remain unclear. In this article, we report that NOX2 controls systemic L. monocytogenes spread through modulation of the type I IFN response, which is known to be exploited by L. monocytogenes during infection. NOX2 deficiency results in increased expression of IFN-stimulated genes in response to type I IFN and leads to 1) promotion of cell-to-cell spread by L. monocytogenes, 2) defective leukocyte recruitment to infection foci, and 3) production of anti-inflammatory effectors IL-10 and thioredoxin 1. Our findings report a novel antimicrobial role for NOX2 through modulation of type I IFN responses to control bacterial dissemination.
Patient barrier acceptance during airway management among anesthesiologists: a simulation pilot study
Authors: Querney Jill , Cubillos Javier , Ding Youshan , Cherry Richard , Armstrong Kevin
Published: December 2020

Background: Protection of healthcare providers (HCP) has been a serious challenge in the management of patients during the coronavirus 2019 (COVID-19) pandemic. Additional physical barriers have been created to enhance personal protective equipment (PPE). In this study, user acceptability of two novel barriers was evaluated and the performance of airway management using PPE alone versus PPE plus the additional barrier were compared. Methods: An open-label, double-armed simulation pilot study was conducted. Each participant performed bag-mask ventilation and endotracheal intubation using a GlideScope in two scenarios: 1) PPE donned, followed by 2) PPE donned plus the addition of either the isolation chamber (IC) or aerosol box (AB). Endotracheal intubation using videolaryngoscopy was timed. Participants completed pre- and post-simulation questionnaires.Results: Twenty-nine participants from the Department of Anesthesia were included in the study. Pre- and post-simulation questionnaire responses supported the acceptance of additional barriers. There was no significant difference in intubating times across all groups (PPE vs. IC 95% CI, 26.3–35.1; PPE vs. AB 95% CI, 25.9–35.5; IC vs. AB 95% CI, 23.6–39.1). Comparison of post-simulation questionnaire responses between IC and AB showed no significant difference. Participants did not find the additional barriers negatively affected communication, visualization, or maneuverability. Conclusions: Overall, the IC and AB were comparable, and there was no negative impact on performance under testing conditions. Our study suggests the positive acceptance of additional patient protection barriers by anesthesia providers during airway management.
Effects of Female Sex Hormones on the Development of Atherosclerosis
Authors: Hsu Sung-Po , Lee Wen-Sen
Published: December 2020

Atherosclerosis and associated pathologies, such as coronary artery disease, peripheral vascular disease, and stroke, are still the leading cause of death in Western society. The impact of female sex hormones on cardiovascular diseases has been studied intensively with conflicting findings. The controversy is mainly due to the differences in groups sampling, animal models used, hormonal treatment regimens, and the data analyzed. In the present article, the results of in vitro and in vivo studies and clinical trials are under review.
Free rational points on smooth hypersurfaces
Authors: Browning Tim D. , Sawin Will
Published: December 2020

Motivated by a recent question of Peyre, we apply the Hardy–Littlewood circle method to count “sufficiently free” rational points of bounded height on arbitrary smooth projective hypersurfaces of low degree that are defined over the rationals.
Essential dimension of representations of algebras
Authors: Scavia Federico
Published: December 2020

Let

k

be a field,

A

be a finitely generated associative

k

-algebra and Rep

_A[n]

be the functor Fields

_k\to

Sets, which sends a field

K

containing

k

to the set of isomorphism classes of representations of

A_K

of dimension at most

n

. We study the asymptotic behavior of the essential dimension of this functor, i.e., the function

r_A(n) := \mathrm {ed}_k

(Rep

_A[n])

, as

n\to\infty

. In particular, we show that the rate of growth of

r_A(n)

determines the representation type of

A

. That is,

r_A(n)

is bounded from above if

A

is of finite representation type, grows linearly if

A

is of tame representation type, and grows quadratically if

A

is of wild representation type. Moreover,

r_A(n)

allows us to construct invariants of algebras which are finer than the representation type.
On Borel Anosov representations in even dimensions
Authors: Tsouvalas Konstantinos
Published: December 2020

We prove that a word hyperbolic group which admits a

P_{2q+1}

-Anosov representation into

\mathsf{PGL}(4q+2, \mathbb{R})

contains a finite-index subgroup which is either free or a surface group. As a consequence, we give an affirmative answer to Sambarino's question for Borel Anosov representations into

\mathsf{SL}(4q+2,\mathbb{R})

.
On the decomposability of mod 2 cohomological invariants of Weyl groups
Authors: Hirsch Christian
Published: December 2020

We compute the invariants of Weyl groups in mod 2 Milnor

K

-theory and more general cycle modules, which are annihilated by 2. Over a base field of characteristic coprime to the group order, the invariants decompose as direct sums of the coefficient module. All basis elements are induced either by Stiefel–Whitney classes or specific invariants in the Witt ring. The proof is based on Serre’s splitting principle that guarantees detection of invariants on elementary abelian 2-subgroups generated by reflections.
Involutions and Chern numbers of varieties
Authors: Haution Olivier
Published: December 2020

Consider an involution of a smooth projective variety over a field of characteristic not two. We look at the relations between the variety and the fixed locus of the involution from the point of view of cobordism.We show in particular that the fixed locus has dimension larger than its codimension when certain Chern numbers of the variety are not divisible by two, or four. Some of those results, but not all, are analogues of theorems in algebraic topology obtained by Conner–Floyd and Boardman in the sixties. We include versions of our results concerning the vanishing loci of idempotent global derivations in characteristic two. Our approach to cobordism, following Merkurjev’s [16], is elementary, in the sense that it does not involve resolution of singularities or homotopical methods.
Renormalization and Siegel disks for complex Hénon maps
Authors: Gaidashev Denis , Radu Remus , Yampolsky Michael
Published: December 2020

We use hyperbolicity of golden-mean renormalization of dissipative Hénon-like maps to prove that the boundaries of Siegel disks of sufficiently dissipative quadratic complex Hénon maps with golden-mean rotation number are topological circles.

Conditionally on an appropriate renormalization hyperbolicity property, we derive the same result for Siegel disks of Hénon maps with all eventually periodic rotation numbers.
Poisson boundaries of lamplighter groups: proof of the Kaimanovich–Vershik conjecture
Authors: Lyons Russell , Peres Yuval
Published: December 2020

We answer positively a question of Kaimanovich and Vershik from 1979, showing that the final configuration of lamps for simple random walk on the lamplighter group over

\mathbb Z^d (d \geq 3)

is the Poisson boundary. For

d \geq 5

, this had been shown earlier by Erschler (2011). We extend this to walks of more general types on more general groups.
Rancang Bangun Sistem Anti Overloading Pada Kendaraan Barang Berbasis Mikrokontroler Menggunakan Sensor Jarak
Authors: Ahmad Rivaldy Dhea , Sasmito Agus , Handoyo Tri
Published: December 2020

Kendaraan barang yang selama ini diandalkan sebagai alat distribusi barang nampaknya memiliki berbagai permasalahan. Masalah yang muncul adalah akibat dari kelalaian pengguna dengan memberikan beban muatan yang berlebih pada kendaraan tersebut. Berbagai permasalahan yang dapat terjadi karena muatan berlebih pada angkutan barang apabila tidak ditanggapi dengan serius dapat menyebabkan kerugian yang semakin besar. Memanfaatkan teknologi saat ini, dikembangkannya sebuah sistem anti overloading pada kendaraan barang yang dapat mengatasi permasalahan kelebihan muatan. Di dalam perancangan alat ini perlu dilakukan eksperimen awal untuk mencari batas jarak beban aman sebagai dasar membuat program. Metode penelitian yang digunakan pada penelitian ini adalah Research and Development (R&D) yang merupakan suatu proses untuk mengembangkan produk baru atau menyempurnakan produk yang telah ada. Desain pemasangan dari sistem anti overloading pada rangka chasis bawah untuk mendeteksi batas jarak beban aman dan beban muatan antara rangka chasis bawah dengan dumper kendaraan. Kinerja sistem menggunakan sensor jarak pada alat peraga dengan beban yang diberikan dapat bekerja dengan baik serta alat dapat memberikan kinerja output sesuai dengan pemrograman yang telah dirancang seperti menampilkan hasil pembacaan jarak dan beban muatan pada handphone Android. Tingkat akurasi dari fungsi sensor terhadap pembacaan jarak memiliki persentase rata-rata success 100% dan error 0%.
Pengaruh Tekanan Ban Terhadap Konsumsi Bahan Bakar Pada Kendaraan Bus Isuzu
Authors: Isbahuddin M. Asrol , Sahri Agus , Aziz Kurniawan Moch
Published: December 2020

Bus yang dimiliki oleh perusahaan harus mampu memberikan performa yang optimal dan dapat memberikan keuntungan bagi perusahaan. Hal tersebut dapat dilihat dari salah satu komponen kendaraan tersebut yaitu ban. Penelitian ini bertujuan untuk mencari besaran rolling resistance pada tiap variasi tekanan ban dan pengaruhnya terhadap konsumsi bahan bakar. Untuk mencari besaran rolling resistance pada tiap variasi tekanan ban, peneliti melakukan eksperimen tentang metode coast down. Pada tahap perhitungan konsumsi bahan bakar setiap variasi tekanan ban menggunakan metode kuantitatif. Hasil penelitian ini menunjukkan bahwa adanya pengaruh tekanan ban terhadap konsumsi bahan bakar pada kendaraan bus Isuzu. Pada tekanan ban depan 68 psi dan belakang 85 psi menghasilkan gaya Rr 769,692 N dengan konsumsi bahan bakar 304,622 liter/tahun. Pada tekanan 58 psi dan 75 psi gaya Rr sebesar 874,650 N dengan konsumsi bahan bakar 346,161 liter/tahun. Tekanan 48 dan 65 psi menghasilkan gaya Rr 973,643 N dengan konsumsi bahan bakar 385,340 liter/tahun. Pada tekanan 38 psi dan 55 psi gaya Rr sebesar 1.066,293 N dan konsumsi bahan bakar 422,008 liter/tahun. Semakin turun tekanan ban, semakin besar gaya rolling resistance dan konsumsi bahan bakar semakin meningkat.
Efektivitas Penataan Parkir Di Badan Jalan Terhadap Peningkatan Kinerja Ruas Jalan (Studi Kasus Jalan Ir.H Juanda Kota Sukabumi)
Authors: Wijayanti Rani Wijayanti , Budi Purwantoro Agus , Sutardjo Sutardjo
Published: December 2020

Ruas Jalan Ir.H. Juanda Kota Sukabumi merupakan kawasan komersial dan kawasan pendidikan dengan lokasi parkir yang berada di jalan (on street). Permasalahan mengenai parkir yang ada pada ruas jalan tersebut memberikan dampak terhadap kapasitas jalan yang ada. Parkir yang tidak tertata dengan rapi membuat kinerja ruas jalan tersebut menjadi kurang baik. Metode yang digunakan dalam penelitian ini adalah dengan menggunakan perhitungan kinerja ruas jalan berdasarkan MKJI 1997. Perhitungan kinerja parkir menggunakan perhitungan karakteristik parkir hingga indeks parkir serta penentuan pola parkir berdasarkan Pedoman Teknis Fasilitas Parkir. Hasil dari penelitian ini adalah direkomendasikan untuk penetapan pola parkir untuk kendaraan roda 4 dari sudut 0° menjadi sudut 45⁰ dikarenakan hal ini akan lebih menerima kapasitas kendaraan lebih banyak dan pola parkir sudut 90° menjadi sudut 45⁰ untuk kendaraan sepeda motor. Perubahan sudut parkir mempengaruhi perubahan jumlah SRP menjadi 57 petak untuk SRP kendaraan ringan. Sedangkan berdasarkan analisis yang dilakukan 2 SRP kendaraan ringan dapat digunakan untuk 10 SRP sepeda motor. Jumlah SRP yang dihasilkan setelah dilakukan perubahan sudut adalah 135 petak untuk sepeda motor dan 30 petak untuk kendaraan ringan.
Evaluasi Rekayasa Lalu Lintas Simpang Empat Bundaran Bersinyal Tugu Wisnu Surakarta
Authors: Evitmalasari Meilana , Sasmito Agus , Rokhim Abdul
Published: December 2020

Salah satu upaya peningkatan keselamatan jalan ialah dengan mengurangi risiko terjadinya kecelakaan di simpang dengan cara mengoptimalkan kinerja simpang serta menurunkan jumlah konflik lalu lintas yang terjadi. Berdasarkan hal tersebut penulis melakukan penelitian upaya peningkatan keselamatan dengan cara penanganan konflik lalu lintas dan mengoptimalkan kinerja simpang. Penelitian ini bertujuan untuk memberikan penanganan simpang yang dapat diterapkan pada simpang empat Tugu Wisnu guna mewujudkan peningkatan keselamatan. Permasalahan pada simpang ini adalah terdapat ekor tundaan lalu lintas yang tertinggal pada bundaran sehingga menyebabkan konflik lalu lintas dengan arus lalu lintas pendekat simpang lainnya dengan fase APILL sama. Metode yang digunakan dalam analisis kinerja simpang menggunakan perhitungan MKJI dan disimulasikan menggunakan software Vissim  9 Full Version sedangkan metode untuk mengetahui konflik lalu lintas yang terjadi dengan menggunakan software SSAM. Kemudian memberikan usulan penanganan untuk diterapkan pada simpang empat Tugu Wisnu yaitu dengan perubahan pengaturan simpang 3 fase menjadi 4 fase dengan pergerakan lalu lintas mengelilingi bundaran serta 4 fase tanpa mengelilingi bundaran kemudian dari kedua usulan penanganan dipilih alternatif penanganan yang sesuai untuk menurunkan konflik lalu lintas dan mengoptimalkan kinerja simpang. Alternatif penanganan simpang yang dipilih berupa perubahan pengaturan simpang dengan 4 fase dengan pergerakan lalu lintas tanpa mengelilingi bundaran dapat menurunkan jumlah konflik lalu lintas sebesar 30% dan tingkat pelayanan simpang adalah D yang berarti terciptanya keselarasan antara keselamatan jalan dan kelancaran lalu lintas.
PODSTICANJE ASERTIVNE KOMUNIKACIJE UČENIKA PUTEM RADIONIČARSKOG RADA U OKVIRU ODELJENSKE ZAJEDNICE
Authors: Milošević Danijela
Published: December 2020

The study discusses the assertive style of communication as a constructive pattern in the realization of social interactions of pupils and the formation of a quality pedagogical climate in the classroom. The classroom teaching is recognized as an opportunity to develop non-violent communication and democratic relations of pupils, and a teacher is perceived as a key actor in encouraging a cooperative atmosphere and prosocial behavior of pupils. Workshops are presented as an effective form of experiential, cooperative and active learning, which contribute to the regulation of interpersonal relationships of pupils. The practical value of the work is reflected in the presentation of the educational workshop, designed to enable pupils to apply an assertive style of communication. Since the establishment and development of successful interpersonal communication in teaching depends on a teacher, the study points out the importance of developing his/her social competencies. Orientation towards permanent education and continuous development of reflective practice is the priority of the modern teacher, who aspires to change and innovate the teaching process. School practice requires the modernization of teacher education and its professional roles, in order to achieve the educational function and develop pupils’ competencies for life in the 21st century.
ELECTRONIC SYSTEMS OF INTELLIGENT VEHICLES
Authors:   State Research Center of the Russian Federation FSUE “NAMI”, ENDACHEV Denis V. , BAKHMUTOV Sergey V. ,   State Research Center of the Russian Federation FSUE “NAMI”, EVGRAFOV Vladimir V. ,   State Research Center of the Russian Federation FSUE “NAMI”, MEZENTCEV Nikolay P. ,   State Research Center of the Russian Federation FSUE “NAMI”
Published: December 2020

Modern automotive engineering is closely related to the implementation of information systems. In automobile transport, the range of such developments is considerably wide: from driver assistance systems (ADAS — Advanced Driver Assistance System) to full autopilot systems. The article provides a brief overview of the state of the problem and presents the main directions of development of the State Research Center of the Russian Federation FSUE “NAMI” in the field of ADAS and highly automated (unmanned) vehicles. Descriptions of on-board vehicle systems of a high level of automation are given developed by the State Research Center of the Russian Federation FSUE “NAMI” with the participation of manufacturers. The article also describes the key technologies of machine vision systems, test sites for highly automated vehicles.
DEVELOPMENT OF MINIMALLY ALLOYED STRUCTURAL STEEL FOR LARGE MODULE GEARS OF TRANSMISSIONS
Authors:   Joint Institute of Mechanical Engineering of the NAS of Belarus, RUDENKO Sergei P. , VALKO Aleksandr L. ,   Joint Institute of Mechanical Engineering of the NAS of Belarus, SANDOMIRSKI Sergei G. ,   Joint Institute of Mechanical Engineering of the NAS of Belarus
Published: December 2020

In the world practice of manufacturing gears for automotive equipment, a search is being made for new, more effective steel grades and ways to realize their advantages, achieved both during smelting and during further thermal, deformation and chemical-thermal treatment. There is a tendency to reduce the nickel content in structural steel grades and replace them with sparingly alloyed, microalloyed with strong carbide-forming elements. The condition for using sparingly alloyed structural steels is the ability to find a compromise between increasing the reliability and durability of machine parts and saving deficient alloying materials. Based on this, the article formulates the main provisions that should be taken into account when developing minimally alloyed structural steel compositions for manufacturing highly stressed gears of mobile machine transmissions. It is shown that the introduction of new sparingly alloyed steel grades leads to the need to develop new technologies with the solution in each case of the problem of assessing the impact of alloying elements and microadditives on the hardenability of steel. The method of minimum doping of steel for gears with a module of 10 mm is given. Based on the application of a new approach, a new minimally alloyed structural steel has been developed that provides high strength, fatigue and technological characteristics of large module gears. The hardenability of the core and cemented layers of the developed steel is determined, which provides the life of the gears for at least 1,000 hours in operating conditions at contact stresses in the engagement pole σН = 1,800 MPa.
On The Norms of Another Form of $r-$Circulant Matrices with The Hyper-Fibonacci and Lucas Numbers
Authors: BAHŞİ Mustafa , SOLAK Süleyman
Published: December 2020

In this paper, we compute the spectral norms of $r-$ circulant matrices with the hyper-Fibonacci and hyper-Lucas numbers of the forms $F_{r}=Circ-r(F_k^{(0)},F_k^{(1)},...,F_k^{(n-1)}) $, $L_r=Circ-r(L_{k}^{\left( 0\right) },L_{k}^{\left( 1\right) },...,L_{k}^{\left( n-1\right) })$ and their Hadamard and Kronecker products. For this, we firstly compute the spectral and Euclidean norms of circulant matrices of the forms $F=Circ(F_{k}^{\left( 0\right) }, F_{k}^{\left( 1\right) },... ,F_{k}^{\left( n-1\right) })$ and $L=Circ(L_{k}^{\left( 0\right) },L_{k}^{\left( 1\right) },...,L_{k}^{\left( n-1\right) })$. Moreover, we give some examples related to special cases of our results.
The Analysis of Mathematical Skills Used in the Software Industry
Authors: AKDUR Deniz
Published: December 2020

Mathematical skills can provide a scientific basis for software engineering (SE) activities by helping practitioners comprehend the unambiguous logic, which is critical for both abstract thinking and problem solving besides development of any applications in the software industry. Many practitioners in different roles take different mathematics courses at the university education; however there are various perceptions about the necessity and the weight of these courses. \textit{"What are their usage in the software industry?}" or \textit{"do we need such a (heavy) mathematical curriculum at the university?}" are frequently asked questions for software teams. To better understand different opinions, we utilized the results of our survey, which investigated the skills gaps in the software industry. 628 Turkey-educated practitioners, whose undergraduate degree was completed in Turkey, working in 13 countries responded the survey. In this paper, we examined different perceptions (1) about the usage of the mathematics courses in the software industry; and (2) about current weight of these courses in the curriculum. The findings shed light on the perceptions about mathematical skills in the industry by presenting various cross-factor analysis.
A CLINICAL STUDY TO EVALUATE THE ANTIHYPERTENSIVE EFFECT OF TRINPANCHMOOL KWATH IN MANAGEMENT OF ESSENTIAL HYPERTENSION
Authors: Prerna  , Vijay Chaudhary  , B.L. Mehra
Published: December 2020

The present study was conducted to evaluate the antihypertensive effect of an Ayurvedic formulation Trinpanchmool Kwath in the management of essential hypertension. The study was conducted in 30 patients selected from OPD and IPD of R.G.G. P.G.A.C. and Hospital, Paprola. Patients were randomly divided into three groups. Group- I patients were managed with Trinpanchmool Kwath , Group- II patients were managed with Tab Chlorthalidone and Group– III patients were managed with both Trinpanchmool Kwath and Tab. Chlorthalidone. The results obtained were analysed on the basis of various objective and subjective parameters. However change in blood pressure was the main criteria for assessing the effect of the therapy. Statistically highly significant reduction was observed in systolic and diastolic blood pressure after 45 days of therapy. In Group-I systolic blood pressure reduced by 9.374%, in Group-II systolic blood pressure decreased by 15.46% and in Group-III systolic blood pressure decreased by 16.86%. Similarly in Group-I diastolic blood pressure decreased by 8.195% , in Group-II showed 11.250% reduction and in Group-III diastolic blood pressure decreased by 12.17% after completion of therapy. Results revealed that therapy given in Group-III i.e. the combination of Trinpanchmool Kwath and Tab. Chlorthalidone showed best results as compared to other groups. Group-II, in which patients were managed with Tab Chlorthalidone showed better results over Group-I where only Trinpanchmool Kwath was given to the patients. However statistically highly significant reduction in both systolic and diastolic pressure was observed in all three groups.
PREVENTION AND MANAGEMENT OF GUDAGATA VIKARA (ANORECTAL DISORDERS)- AYURVEDIC PERSPECTIVE
Authors: Borkar Sneha P  , Dongre Amol A
Published: December 2020

Gudagata Vikara (Anorectal disorders) refers to ailments of the anus and/ or rectum. Gudagata Vikara includes; Arsha (Haemorrhoids), Bhagandara (Fistula in Ano), Parikartika (Fissure in Ano), Guda Kandu (Pruritus Ani), etc. These are some common disorders in human being. A study by Sharma et al. showed that Hemorrhoids (49%) and fistula-in-ano (27%) were commonest anorectal conditions, mostly affecting the age group 18-45 years. Apathya Ahara and Vihara leads to vitiation of Doshas causing Mandagni and vitiation of Apanavayu resulting in stagnation of Mala in Gudavali which leads to anorectal disorders. In present study a thorough and scientific review of Ahara (diet) and Vihara (lifestyle) has been carried out for the prevention and management of anorectal diseases. Materials and methods: Ayurvedic treaties, text books, Dissertation, Articles from PUBMED, SCOPUS, Google scholar, Mesh, Google search has been searched thoroughly related to the subject.
Discussion: Gudagata Vikara, Anorectal Disorders, Ahara (Diet), Vihara (Lifestyle), Dinacharya, Ritucharya, Sadvritta has been discussed.
Conclusions: Food articles mentioned in Ayurvedic text are effective in the management of Anorectal diseases. Lifestyle changes according to Dinacharya, Ritucharya and Sadavritta and following do’s and don’ts are effective in the management of Anorectal diseases
Corticosteroids in the treatment of SARS-CoV-2 related lung disease
Authors: Ivaschkin V. T. , Zolnikova O. Yu. , Svistunov A. A. , Dzhakhaya N. L. , Potskhverashvili N. D. , Kokina N. I. , Buklis E. R. , Roshchina T. V. , Komkova I. I. , Nadinskaia M. Yu.
Published: December 2020

Aim. To explore the effectiveness of corticosteroids in patients with lung damage caused by SARS-CoV-2.

Materials and methods. The retrospective study included patients with confirmed SARS-CoV-2 infection and lung damage diagnosed by computed tomography (CT), who was receiving low molecular weight heparin (LMWH). 56 patients included in Group 1 received dexamethasone 4–12 mg/day for 8–10 days after admission to the hospital. 30 patients included in Group 2 (control group) had no dexamethasone treatment. The laboratory and instrumental data obtained from the patients under admission and for the 8–10th day of the treatment were analyzed. Hospital mortality was evaluated by Kaplan — Meier method. To predict a lethal outcome, we have used the logistic regression method.

Results. By the 8–10th day of hospitalization, only in the Group 1, there was a statistically significant decrease in the volume of lung tissue lesions by CT (p = 0.027), fibrinogen concentration (p = 0.001). A statistically significant decrease of the C-reactive protein concentration was noted for the both groups. Oxygen therapy was more often needed in Group 2 (26 patients — 87%) in opposite to Group 1 (36 patients — 64%) (p = 0.028). Hospital mortality was 3.6% in Group 1 and 13.3% in Group 2 (p = 0.177). There was a trend towards an increase in patient survival in Group 1 between 18 and 28 days of hospitalization (Mantel — Cox test, p = 0.095). Age (p = 0.012), percentage of CT lesions at the time of admission (p = 0.020) and assignment to the dexamethasone group (p = 0.080) were included in the logistic regression equation.

Conclusion. For the patients with SARS-CoV-2 lung damage, treatment with dexamethasone 4–12 mg, started from the first day of hospitalization additionally to LMWH, contributes to positive CT dynamics on the 8–10th day and decreases hospital mortality.
Complex mechanism of COVID-19 development
Authors: Bolevich S. B. , Bolevich S. S.
Published: December 2020

Coronavirus infection (COVID-19) is an acute viral disease, which affects all vital organs and is caused by an RNA-genomic virus of the genus Betacoronavirus of the family Coronaviridae. This virus (SARS-CoV-2) enters the body through the respiratory tract and interacts primarily with Toll-like receptors of epithelial cells of the bronchi, alveoli, intestines and vascular endotheliocytes, as well as with angiotensin-converting enzyme 2 receptors. Toll-like receptors activate nuclear factor Kappa B in these cells, which initiates the formation of many cytokines (“cytokine storm”). SARS-CoV-2 affects type II pneumocytes by causing a termination of surfactant formation and, accordingly, alveolar shrinking and the formation of acute respiratory distress syndrome and also fibrosis on the interalveolar-capillary membrane and the formation of acute respiratory failure. SARS-CoV-2 and cytokines disrupt the function of vascular endothelial cells, which leads to endothelial dysfunction. In microvessels forms a mass formation of microthrombi, which causes the failure of organs and systems. “Cytokine storm” turns into cytokine sepsis with the formation of multiple organ dysfunction syndrome.
Learning Motivation and Parents' Socio-Economic Conditions on College Interest
Authors:   Economic Education, Universitas Pendidikan Ganesha, Indonesia, Irwansyah M. Rudi
Published: December 2020

Continuing education to college is everyone's dream. Although not all have the same opinion about it, but continuing education to the highest level is the dream of almost everyone. Several studies have examined this, as well as this research. This research tries to reveal the influence of learning motivation, socioeconomic conditions on college interest, (3) simultaneously between learning motivation and socioeconomic conditions on college interest. Vocational high School of Accounting grade XII students are used as the population. Proportional random sampling as a sampling technique by setting as many samples 58 student. Data collection techniques used are the questionnaire and documentation multiple linear regression analysis as data analysis. The results of data processing showed (1) there was a significant influence of learning motivation on interest in Vocational high School with a value of sig 0,000 <0.05, (2) economic conditions had no effect on interest in college indicated sig value of 0.403 > 0.05, and the learning motivation and conditions socioeconomic simultaneously has a significant effect on interest in higher education with a value of sig 0,000 <0.05.
Emotional intelligence as an indicator of coping Skills among undergraduate dental students at Peshawar: a correlational study
Authors: Basheer Rehman  , Brekhna Jamil  , Admin
Published: December 2020

Abstract

Objective: The objective of this study is to determine correlation between emotional intelligence and academic stress.

Methodology: This quantitative correlational study was conducted in Khyber College of Dentistry Peshawar. A total of 298 undergraduate dental students from first year to final year session 2015-16 of all ages and genders were included in this study. Emotional intelligence score Dental Environmental Stress were calculated using Mean and SD. A one way ANOVA & Tukey Post hoc tests were performed for Emotional Intelligence and academic stress separately to compare the mean difference between academic groups.  A spearman correlation coefficient was used to check relationship between Emotional Intelligence and academic stress with different academic levels. EI and academic stress were correlated using Pearson Correlation.

Results: Out of 298 students, 98 (32.89%) were males and 200 (67.11%) were females with a male to female ratio of 2.04:1. The mean EI score of all the BDS students from first year to final year was 81.23 ± 22.8. The total mean DES score of all classes was 109.54 ± 19.5 with a trend of decreasing stress levels from first year to final year. A Pearson correlation test was run. Statistically significant (r:-.766: P Value: .001, N: 298) negative strong relationship between EI and academic stress exists.

Conclusion: The gradual increase of EI from first year to final year showing the importance of teaching and learning methods which incorporate certain trends of EI in the students overall training.

Key words: Emotional Intelligence, Coping skills, Undergraduate dental students
Mixoma Atrial Esquerdo Envolvendo Manifestações Multissistêmicas em Paciente Idosa
Authors:   Hospital Ana Nery, Universidade Federal da Bahia. Salvador, BA, Brasil., de Assis Reis Vanessa , Oliveira Isabella Bruno ,   Hospital Ana Nery, Universidade Federal da Bahia. Salvador, BA, Brasil., Loula Novais de Paula Marcelo ,   Hospital Ana Nery, Universidade Federal da Bahia. Salvador, BA, Brasil., Terra Fonseca Barreto Ana ,   Hospital Ana Nery, Universidade Federal da Bahia. Salvador, BA, Brasil.
Published: December 2020

Os mixomas atriais podem evoluir de forma assintomática ou se apresentar com manifestações sistêmicas. O ecocardiograma é um exame complementar eficaz em diagnosticar tal patologia. A cirurgia cardíaca representa o tratamento definitivo e, quando realizada no momento preciso, pode evitar complicações relacionadas ao crescimento e embolização tumoral. É descrito o caso de uma paciente idosa de alto risco cardiovascular, admitida por infarto agudo do miocárdio com supradesnivelamento de ST em unidade cardiológica, com evolução para choque cardiogênico, tendo esse contexto contribuído para baixa suspeição inicial de tumor cardíaco.
Differences in body mass among the frugivorous bats Artibeus lituratus and Carollia perspicillata (Chiroptera: Phyllostomidae) from an urban and a peri-urban area of Cúcuta, Colombia
Authors: Acevedo Aldemar , Pabón Friedman
Published: December 2020

We report differences in body mass of two species of fruit bats, Artibeus lituratus and Carollia perspicillata, from two fragments of tropical dry forest (TDF) located in urban and peri-urban areas of the city of Cúcuta, Colombia. From January to September 2018 bat sampling was carried out using mist nets to captured and weigh individuals in the field. The analysis was based only on adults who were not in a reproductive state. We found that both males and females of each species had a higher body mass in the peri-urban area than in the urban area. This highlights the importance of testing subsequent hypotheses to explain the body mass variations reported in this note in response to effects related to diet, diseases, and changes in land use, among others.
Retórica e política dionisíacas em Acarnenses de Aristófanes
Authors: Buarque de Holanda Luisa Severo
Published: December 2020

Acarnenses é a única comédia de Aristófanes em que uma personagem fala explicitamente em nome do autor. Em geral, é apenas o coro quem desempenha o papel de porta-voz declarado do comediógrafo, nas parábaseis de suas obras. Nessa peça, ao contrário, vemos o protagonista usar a primeira pessoa para referir-se a um evento exterior à trama cômica, e supostamente ocorrido com o autor do texto (o conhecido processo que Cléon teria movido contra Aristófanes). Essa estratégia, por si só, permite à obra apresentar um complexo entrelaçamento de temas: a autodefesa do protagonista Diceópolis, por ter firmado trégua privada com Esparta (que remete, em jogo paratrágico, à autodefesa de Télefo na tragédia euripideana de mesmo nome); a autodefesa que o próprio autor Aristófanes realiza, a fim de refutar as acusações formuladas por Cléon contra ele; a autodefesa da comédia, por comparação com a tragédia. Como se pode notar, trata-se de uma superposição de camadas apologéticas, cuja maior característica são os procedimentos meta-teatrais e meta-retóricos. Neste artigo, pretendo analisar algumas das várias relações entre comédia, retórica e política que o texto de Aristófanes sugere. E pretendo, por fim, extrair de tal análise algumas conclusões a respeito do caráter dionisíaco da 'política' aristofânica.
O Fantasma de Zabut
Authors: Maggio (aut.) Antonella , Mannina (apres.) Paolo , Cottone (apres.) Rossella Saetta , Moreira (trad.) Fernando José De Santoro
Published: December 2020

O FANTASMA DE ZABUTde Antonella Maggio(Tradução de Fernando Santoro, apresentação Rossella Saetta Cottone e Paolo Mannina ) do original:MAGGIO, Antonella, Il Fantasma di Zabut, Salvatore Estero Editore, Sciacca, 2017 Fábula infantil sobre a diversidade cultural, a hospitalidade e a liberdade.
Eficacia del programa educativo "exprésate" sobre los conocimientos del embarazo adolescente en jóvenes de Huancavelica
Authors: Muñoz De la Torre Rossibel , Clemente-Cóndor Luz , Carbajal-Chávez Cintya , Toral-Santillán Edwin
Published: December 2020

Objetivo: Evaluar la eficacia del programa educativo “Exprésate” sobre el nivel de conocimiento del embarazo adolescente en las estudiantes de la Institución Educativa. Francisca Diez Canseco de Castilla, Huancavelica, Perú. Material y métodos: Estudio de diseño cuasi experimental trabajado con 205 estudiantes femeninas distribuidos en 8 secciones (A-H), una de ellas (“E”) se tomó como prueba piloto conformado por 30 estudiantes, para la validación del cuestionario Pre-Test y Pos-Test a través del KR-20; luego se desarrolló sesiones secuenciales del programa educativo “Exprésate” con pre y post test. La variación de indicadores fue evaluada mediante la prueba de rangos de Wilcoxon para muestras pareadas, con un nivel de confianza del 95%. Resultados: En el Pre-Test el 24,55% mostró un nivel de conocimiento bajo (5,02±1,22); un 74,55% medio (9,52±1,76) y un 0,90% alto (15,5±0,71); mientras que en el Pos-Test, realizado concluido el programa educativo, se halló que el 23,90% presentó un nivel de conocimiento medio (13,02±1,36) y un 76,10% presentó un nivel alto (16,81±1,36), así mismo, la variación de los valores pre y post test resultó ser estadísticamente significativa (p<0,001). Conclusión: El programa educativo “Exprésate” es eficaz sobre el nivel de conocimiento del embarazo adolescente.
SIMULATION AND PERFORMANCE ANALYSIS EVALUATION FOR MULTIPATH EXTENSION OF AODV TO IMPROVE END TO END DELAY, ROUTE ERROR SENT, ROUTING LOAD AND PACKET DROP RATIO
Authors: JAIN MANJHARI , WAOO AKHILESH , Patheja P. S.
Published: December 2020

This paper describes improvement in standard routing protocol AODV for mobile ad-hoc networks. Our mechanism setups multiple optimal paths based on bandwidth and delay. It allows to store multiple optimal paths based on Bandwidth and delay. At time of link failure, it will switch to next available path. To set up multiple paths, we have used the information that we get in the RREQ packet and also send RREP packet to more than one path. It reduces overhead of local route discovery at the time of link failure and because of this End to End Delay and Drop Ratio decreases. The main feature of our mechanism is that it is simple, efficient. We evaluate through simulations the performance of the AODV routing protocol including our scheme and we compare it with HLSMPRA (hot link split multi-path routing algorithm) Algorithm. Indeed, our scheme reduces routing load, End to End Delay, route error sent, and Packet drop ratio. The simulations have been performed using network simulator OPNET-14.0. The network simulator OPNET is discrete event simulation software for network simulations which means it simulates events such as sending, receiving, forwarding and dropping packets.
El entramado de la Historia Oral
Authors: Ramírez Rivera Bianca
Published: December 2020

Reseña crítica sobre el libro

De Garay Arellano, Graciela y Jorge Eduardo Aceves Lozano (coords.), Entrevistar ¿para qué?: múltiples escuchas diversos cuadrantes, Ciudad de México, 2017, 446pp.
Historiología: Edmundo O'Gorman, José Ortega y Gasset, y los fundamentos de la ciencia de la historia
Authors: Suarez Gomez Ainhoa
Published: December 2020

Historiología es una palabra poco utilizada en teoría y filosofía de la historia. Edmundo O'Gorman, quien teoriza sobre ella en Crisis y porvenir de la ciencia histórica, la hereda del filósofo José Ortega y Gasset. Bajo este vocablo consolida un complejo e innovador programa científico, al tiempo que promueve una visión metahistórica del mundo y su respectivo devenir. El presente trabajo propone un encuentro entre Ortega y O'Gorman a partir de este concepto para: 1) analizar el horizonte cultural en el que emerge la idea ogormaniana de “genuina ciencia histórica” o historiología; 2) examinar el papel protagónico de la filosofía y la concepción sobre la historia de Ortega en el pensamiento de O'Gorman; y 3) estudiar los puntos de encuentro y desencuentro entre las ideas de ciencia de la historia de estos dos autores, así como algunas de las aplicaciones realizadas por O'Gorman en el terreno de la historiografía.
La poética de la historia como ironía: constructivismo, observación y valor reflexivo
Authors: Betancourt Martinez Fernando Jesus
Published: December 2020

El presente escritor busca ejercer una lectura de la obra de Hayden White con el fin de identificar, de sus propuestas tropológicas y poéticas, una serie de implicaciones epistemológicas. Dicho ejercicio requiere suspender el condicionante retórico introducido por White, sin menoscabo del valor de esas implicaciones cognitivas. El elemento básico de este esfuerzo es retomar la condición irónica como compensatoria al proyecto de describir la historia como productora de conocimientos objetivos. La tesis central afirma que la actitud irónica es un camino que permite observar lo inobservable de la operación historiográfica y dotarla de un valor reflexivo que le permite reproducir sus estructuras cognitivas.
Improbidade administrativa e impeachment
Authors: Martins Ives Gandra da Silva
Published: December 2020

Trata-se de estudo no qual o autor analisa os elementos subjetivos que envolvem os atos de improbidade administrativa, que podem levar ao impeachment do mau gestor público, abordando, assim, todas as formas de responsabilização tanto do Estado, quanto do agente público. Neste artigo, fica, pois, demonstrado, que os crimes contra a probidade da administração praticados pelo gestor público, sejam eles culposos ou dolosos, podem dar ensejo ao “impeachment”.
Derecho Administrativo y Derechos Humanos
Authors: Béjar Rivera Luis José
Published: December 2020

En los últimos años del siglo pasado y hacia casi dos décadas del actual, se ha vivido en prácticamente todo el mundo una explosión de los derechos humanos. Con mayor frecuencia encontramos que las Cortes y Tribunales constitucionales invocan violaciones de derechos humanos al momento de dictar sus fallos. Pero antes de ello, el derecho administrativo, aún siendo una rama relativamente joven, nace como una disciplina cuyo objeto es la interdicción de los actos de la autoridad, basado fundamentalmente en la protección de los derechos subjetivos, esto es que, el derecho administrativo construye un sistema de cómo deben ser cumplimentados los derechos de los ciudadanos, de tal forma que su vocación natural es sin duda, la de concretar los derechos humanos.
Terceirização na administração pública: comentários sobre o RE 760.931
Authors: Martins Ricardo Marcondes
Published: December 2020

Recentemente o STF deu parcial provimento ao RE 760.931 para reafirmar o entendimento assentado na ADC 16 sobre a inexistência de responsabilidade subsidiária da Administração nas terceirizações que ela realize, salvo se comprovada sua culpa na fiscalização do contrato. O julgado impõe a retomada do estudo da terceirização pelo Poder Público. A presente análise não apenas examina os efeitos da decisão do STF, mas também todos os desdobramentos que o tema sofrera nas duas últimas décadas.
A invalidação administrativa das concessões de serviços públicos regidas pela lei federal 8.987/1995
Authors: França Vladimir da Rocha , França Catarina Cardoso Sousa
Published: December 2020

No presente trabalho, examinam-se as normas que disciplinam a invalidação administrativa das concessões comuns de serviços públicos, no âmbito do sistema do Direito Positivo brasileiro, notadamente à luz da Lei Federal nº 8.987, de 13 de fevereiro de 1995.
Decaimento e extinção dos atos administrativos
Authors: Cammarosano Márcio
Published: December 2020

A extinção dos atos administrativos é um dos temas que tem sido objeto de estudos dos mais fecundos. É tema clássico que não pode escapar ao labor científico dos administrativistas. Todavia, por mais que tenha merecido a atenção dos estudiosos do Direito Administrativo, parece constituir ainda, pelo menos no Brasil, campo para novas investigações, principalmente para aqueles que, como nós, não estão convencidos de que só se revestem de importância os estudos concernentes especificamente à revogação e à invalidação, como se toda a problemática da extinção fosse por elas açambarcada. A propósito do tema, uma das questões que emerge como desafio aos estudiosos é a de saber se o que se extingue são os atos administrativos em si mesmos considerados ou os seus efeitos. Respostas a questões como essa reclamam prévia definição, ainda que sumária, do que se entende por ato administrativo, sua perfeição, validade, eficácia e seus efeitos. Foi o que também procuramos fazer. Por outro lado, impõe-se questionar em que medida outras figuras jurídicas, como o decaimento, constituem ou não modalidades de extinção dos atos administrativos ou de seus efeitos. Para tanto, cabe, antes, indagar: para significar que situações convêm utilizar o termo “decaimento”? Uma vez delimitado o conceito de decaimento, quais os seus pressupostos?