bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuroimaging Techniques for Neuroplasticity Quantification in Stroke Patients
Authors:   Universidad Autónoma Metropolitana, Rodríguez-García Martín Emiliano , Marín-Arriaga Norma ,   Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Macías-Arriaga Silvia Gabriel ,   Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Salazar-Cárdenas Bernardo ,   Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Ramírez-Rodríguez Tania ,   Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Aparicio-Jiménez Víctor Hugo ,   Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Valdés-Cristerna Raquel ,   Universidad Autónoma Metropolitana, Cantillo-Negrete Jessica ,   Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”
Published: September 2023

Neuroimaging techniques provide relevant information of the functional and anatomical status of the human brain. This information is of particular importance when a pathology, like stroke, produces a brain injury. In stroke patients, it has been determined that neuroplasticity is the primary recovery mechanism of the lost motor function. Due to worldwide high prevalence, especially in developing countries, it is necessary to continue the research of the recovery mechanisms involved in this pathology. To this end, functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) are two of the most used neuroimaging techniques. In stroke patients, fMRI allows the analysis of the neural activity produced by the execution of motor tasks, whereas DTI provides structural information of the brain anatomy. In this narrative review, multiple studies that employ these neuroimaging techniques for quantification of neuroplasticity changes in stroke patients after undergoing a neurorehabilitation program are presented. Better understanding of these neuroplasticity changes would allow researchers to design and provide more beneficial rehabilitation schemes to stroke patients.
La inteligencia artificial generativa y su impacto en la creación de contenidos mediáticos
Authors: Franganillo Jorge
Published: September 2023

La inteligencia artificial (IA) generativa es un campo en rápido avance que ya permite la producción automatizada de contenido textual, gráfico, sonoro y audiovisual de alta calidad. Esta tecnología tiene implicaciones relevantes para el periodismo, la publicidad y el entretenimiento, así como también plantea desafíos éticos, legales y sociales. Este trabajo examina las posibilidades, las limitaciones y los riesgos de la IA generativa para la producción de contenidos en los medios de comunicación. Se analizan los grandes modelos de lenguaje para la generación automatizada de texto, las redes antagónicas generativas para la síntesis de imágenes y vídeos cortos, y la tecnología deepfake para la falsificación de vídeos y la clonación de voces humanas. Se discuten las implicaciones de estas tecnologías para la propiedad intelectual, la veracidad informativa, la identidad personal y la creatividad humana. Como conclusión puede afirmarse que la IA generativa es una herramienta potente e innovadora para la creación de contenidos mediáticos, pero que requiere un uso ético y cuidadoso por parte de los productores y de los consumidores de contenido.
A simple and efficient protocol for generating transgenic hairy roots using Agrobacterium rhizogenes v1
Authors: Ferguson Shaun , B. Abel Nikolaj , Luu Thi-Bich
Published: September 2023

For decades, Agrobacterium rhizogenes (now Rhizobium rhizogenes), the causative agent of hairy root disease, has been harnessed as an interkingdom DNA delivery tool for generating transgenic hairy roots on a wide variety of plants. One of the strategies involves the construction of transconjugant R. rhizogenes by transferring gene(s) of interest into previously constructed R. rhizogenes pBR322 acceptor strains; little has been done, however, to improve upon this system since its implementation. We developed a simplified method utilising bi-parental mating in conjunction with effective counterselection for generating R. rhizogenes transconjugants. Central to this was the construction of a new Modular Cloning (MoClo) compatible pBR322-derived integration vector (pIV101). Although this protocol remains limited to pBR322 acceptor strains, pIV101 facilitated an efficient construction of recombinant vectors, effective screening of transconjugants, and RP4-based mobilisation compatibility that enabled simplified conjugal transfer.Transconjugants from this system were tested on Lotus japonicus and found to be efficient for the transformation of transgenic hairy roots and supported infection of nodules by a rhizobia symbiont. The expedited protocol detailed herein substantially decreased both the time and labour for creating transconjugant R. rhizogenes for the subsequent transgenic hairy root transformation of Lotus, and it could readily be applied for the transformation of other plants.
Neural differentiation on EM grids - iNeurons sample preparation for cryo-ET and CLEM v2
Authors: Capitanio Cristina
Published: September 2023

This is a protocol for differentiating AAVS1-TRE3G-NGN2 iPSCs and hESCs to iNeurons directly on EM grids for cryo-ET and cryo-CLEM. The protocol comprises the following steps: EM grids coating with Matrigel or Poly-Ornithine and Laminin; differentiation and seeding of iNeurons on EM grids; lentiviral transduction for transient expression of fluorescently-labelled proteins; plunge freezing. In this new version, the last step contains a supplemental video with extra context and tips, as part of the ASAP Protocol Particulars, featuring conversations with protocol authors
Lessons learned from the resilience of Chinese public health systems, hospitals and personnel to the COVID-19 pandemic: a scoping review protocol. v1
Authors: Stennett Jack
Published: September 2023

Background: The SARS-CoV-2 pandemic has brought huge strain on hospitals worldwide; however, while the success of China’s COVID-19 strategy has been attributed to achievements of the government, public health officials, and the attitudes of the general public, the resilience shown by China’s hospitals appears to have been a critical factor in their successful response to the pandemic. Objectives: This paper aims to determine the key findings, recommendations and lessons learned in terms of hospital resilience during the pandemic, analyse the quality and limitations of research in this field at present and contribute to the evaluation of the Chinese response to the COVID-19 outbreak, building on a growing literature on the role of hospital resilience in crisis situations. Methods: We conduct a scoping review of evidence on the resilience of hospitals in China during the COVID-19 crisis in the first half of 2020. Two online databases (the CNKI and WHO databases) were used to identify papers meeting the eligibility criteria. After extracting the data, we present an information synthesis using a resilience framework. Articles were included in the review if they were peer-reviewed studies published between December 2019 and July 2020 in English or Chinese and included empirical results pertaining to the resilience of Chinese hospitals in the COVID-19 pandemic.
Estimation of durability properties of self-healing concrete influenced by different bacillus species
Authors:   Dept. of Civil Eng., CVR College of Engineering, Durga Chereddy Sonali Sri , Venkatesh Chava ,   Dept. of Civil Eng., CVR College of Engineering, Muralidhararao T. ,   Dept. of Civil Eng., CVR College of Engineering, Bellum Ramamohana Reddy ,   Dept. of Civil Eng., Aditya Engineering College, Rao B. Naga Malleswara ,   Dept. of Civil Eng., CVR College of Engineering
Published: September 2023

The study was carried out with the influence of four Bacillus species, namely Bacillus subtilis (BS), Bacillus licheniformis (BL), Bacillus halodurans (BH), and Bacillus cereus (BC), in order to improve the impermeable nature of concrete. The selected bacterial agents were cultured according to the nutrient broth medium method and prepared with two variable cell concentrations of 108 and 109. In this study, bacteria were used in two different modes, i.e., as an additive to the concrete and as a curing agent. However, all the concrete specimens were cracked with a 65% stress level concentration and then cured in calcium lactate (only for bacteria-induced concrete specimens) and bacterial solution (only for normal concrete specimens) for crack healing. The durability behavior of these concrete specimens was monitored before crack, after crack, and after healing. In this regard, the following durability tests were performed: Rapid Chloride Permeability Test (RCPT), Water absorption test, Open porosity test, and Acid attack test. From the experimental observations, a decline in the passage of coulombs by 1352 C, water absorption by 3.47%, open porosity by 4.61%, and increased resistance against acid attack was found in normal concrete specimens cured under bacterial solution (especially in Bacillus halodurans with cell concentrations of 109) compared to other ones. Based on the analysis of the results, bacterial cultures have enriched the durability of the concrete by filling the voids and cracks with calcite crystals. However, Bacillus halodurans has shown better durability performance in both types of concrete, i.e., bacterial concrete cured in calcium lactate and normal concrete cured in bacterial solutions.
Parametric optimization of ball milling process parameters for uniform distribution of particles
Authors:   Department of Mechanical Engineering, National Institute of Technology, Arya Rashmi , Singh Hari ,   Department of Mechanical Engineering, National Institute of Technology
Published: September 2023

This paper represents the uniform distribution of particles in a mixture of Silicon Nitride and Hexagonal Boron Nitride using Ball milling process. Here, a novel attempt is made to quantify the uniform distribution of particles in terms of the Experimental Fraction of Observations. The effects of process parameters on Average Particle Size and Experimental Fraction of Observations were studied. Taguchi Methodology was used for Design of Experiments in this study. Optimal factor level settings corresponding to the individual responses were found. Analysis of Variance was conducted as well for both the responses. The mean predicted values of responses and the 95% confidence intervals for the same were also calculated. The confirmation test results are found to lie between the predicted confidence Intervals for both the confirmation experiments and population.
Genetic landscape of acute myeloid leukemias with leukocytosis
Authors: Pekhova K. A. , Sidorova Yu. V. , Severina N. A. , Glinshchikova O. A. , Fevraleva I. S. , Biderman B. V. , Chabaeva Yu. A. , Kulikov S. M. , Luk’yanova I. A. , Kashlakova A. I. , Obukhova T. N. , Dvirnyk V. N. , Sudarikov A. B.
Published: September 2023

Background. Tumor cell proliferation in acute myeloid leukemia (AML) may manifest with high leukocyte counts. In our work, we evaluate the association of high leukocyte counts with individual mutations, as well as their total contribution to the development of leukocytosis in AML. The results obtained should improve our understanding of pathogenic mechanisms leading to the leukocytosis in AML.

Aim. To study the genetic landscape of AML with leukocytosis.

Materials and methods. The laboratory data of 214 AML patients admitted to the National Medical Research Center for Hematology (Moscow) from 2010 to 2022 were retrospectively examined. Real-time PCR, capillary electrophoresis and NGS (next generation sequencing) methods were used to detect mutations of FLT3, NPM1, CEBPA, IDH1/2, DNMT3A, TET2 genes, and CBFB::MYH11, RUNX1::RUNX1T1 chimeric gene transcripts.

Results. Mutations of the FLT3 gene (odds ratio 5.45; p < 0.0001), inv(16)/CBFB::MYH11 (odds ratio 10.03; p = 0.0009) are most associated with leukocyte counts higher than 30 × 109 / L in the debut of AML. Translocation t(8;21)/RUNX1::RUNX1T1 and adverse cytogenetic aberrations, such as -5/del(5q); -7 / del(7q); -17 / abn(17p), complex and monosomic karyotype were significantly associated with leukocyte counts lower than 30 × 109 / L at the time of disease manifestation (p < 0.0001). In the group of patients with intermediate cytogenetic risk bearing only IDH1/2, DNMT3A, and TET2 gene mutations, leukocyte counts at AML debut were significantly lower, whereas the most pronounced leukocytosis was observed in patients with a combination of driver mutations with IDH1/2, DNMT3A, and TET2 gene mutations or FLT3, NPM1, and CEBPA gene mutations.

Conclusion. In addition to the individual effect of certain genetic lesions and cytogenetic aberrations on the proliferative potential of tumor cells, there is a total contribution of various types of genetic events to the development of leukocytosis in AML. High leukocyte counts at the time of AML manifestation in patients with intermediate cytogenetic risk can serve as an indirect marker of the presence of a large number of genetic aberrations with a combination of IDH1/2, DNMT3A, and TET2 gene mutations or FLT3, NPM1, and CEBPA gene mutations.
Resolution of the Expert council “Unsolved problems of targeted therapy for paroxysmal nocturnal hemoglobinuria in Russia”
Authors: Kulagin A. D. , Lukina E. A. , Ptushkin V. V. , Kostinov M. P. , Arshanskaya E. G. , Babaeva T. N. , Ksenzova T. I. , Fidarova Z. T. , Marchenko M. V.
Published: September 2023

On June 24, 2023, an Expert Council was held in St. Petersburg, during which leading experts in the field of hematology discussed current achievements and answered a number of unresolved issues of targeted therapy of paroxysmal nocturnal hemoglobinuria (APG) in order to further improve treatment results in Russia. During the Expert Council, the following aspects of targeted APG therapy were considered: • criteria for the suboptimal response of patients with APG to therapy with inhibitors of the 5th component of complement (C5); • efficacy and safety of the use of pegcetacoplan in APG in patients with insufficient efficacy of inhibitors of the C5 component of complement; • vaccination issues before starting therapy with complement inhibitors and the possibility of conducting treatment with pegcetacoplan at home.
Follicular lymphoma in children and adolescents: clinical, diagnostic and therapeutic features
Authors: Valiev T. T. , Volkova A. S. , Postoykina M. A. , Abramov D. S. , Karibova A. R. , Odzharova A. A. , Ryabukhina Yu. E. , Zeynalova P. A.
Published: September 2023

Ffollicular lymphoma (FL) is one of the most common non-Hodgkin’s lymphomas in adults, while it is a diagnosis of exclusion in adolescents and children. Clinical manifestations of FL in children are represented by long-term asymptomatic lymphadenopathy, less commonly by extranodal areas involvement. treatment standards for FL in children have not been developed and may vary from observational tactics (with the radical resection of a single focus during a biopsy) to the use of radiation therapy and polychemotherapy. Pediatric type follicular lymphoma was first identified as a distinct variant in 2008 in the world Health organization classification of hematopoietic and lymphoid tissue tumors. Clinical, morphological (cytological type 3A), Immunohistochemical (absence of bcl2 expression in the center of the follicle) and cytogenetic (absence of t(14;18)(q32;q21)) features served as the reason for separation into an independent nosological variant. Despite the term “pediatric”, cases of pediatric type FL have been described in adults over 30 years of age. Most often, the disease is diagnosed in the early stages (I, II) and is characterized by a favorable prognosis. In children and adolescents, FL occurs not only of the pediatric type. we present a clinical case of a typical “adult” type FL (grade 1–2) in a 17-year-old patient. the cHop therapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone) with rituximab resulted in a complete remission, which lasted more than 2.5 years.
Use of locally produced anti-CD19 CAR-T cells in the treatment of relapsed/refractory B-cell lymphomas in adults
Authors: Konoplya N. E. , Kalenik O. A. , Severin I. N. , Savritskaya A. A. , Bobrova N. M. , Doroshenko T. M. , Portyanko A. S.
Published: September 2023

Background. Patients with B-cell lymphoma have an extremely unfavorable prognosis after relapse or in case of refractoriness to the first and consecutive lines of immunochemotherapy with the anti-CD19 CAR-T cells being the only therapeutic option to such patients. the manual preparation of anti-CD19 CAR-T lymphocytes was reproduced in the N. N. Alexandrov republican research and practical center for oncology and medical radiology (Minsk). Their safety was demonstrated.

   Aim. To estimate safety, tolerability and efficacy of the in-house CAR-T cells, including objective response rate, progression-free and overall survival.

   Materials and methods. The second generation anti-CD19 chimeric antigen receptor contained an anti-CD19 antibody scFv fragment, CD28 transmembrane domain, 4-1BB and CD3z signaling domains. the coding sequence was cloned into the lentiviral vector S4. The cell product was obtained by expansion of CD4- and CD8-positive lymphocytes populations with IL-7 and IL-15 after initial activation and lentiviral transduction with vector S4. CAR-T cells were infused into 8 patients with refractory forms of B-cell lymphoma after the preliminary lymphodepleting chemotherapy. Persistence of CAR-T cells was assessed by flow cytometry. therapeutic efficiency was assessed by positron emission tomography-computed tomography with 18F-fluorodeoxyglucose.

   Results. Expansion of CAR-T cells with resulting b-cell aplasia was observed in all patients. the median of observation was 113 days (range 22–529 days). objective response rate was 100 %, complete remission was observed in 6 patients, partial response – in 1 patient. One patient died because of complications before the clinical response. Overall survival was 88 ± 12 %. cytokine release syndrome and neurotoxicity were not observed in 6 out of 8 patients despite a high tumor burden.

   Conclusion. Our study demonstrated efficiency and safety of the in-house CAR-T cells for the treatment of patients with refractory B-cell lymphomas.
Risk factors for a differentiation syndrome in patients with acute promyelocytic leukemia
Authors: Semenova A. A. , Troitskaya V. V. , Galtseva I. V. , Parovichnikova E. N.
Published: September 2023

Differentiation syndrome (DS) is a severe complication of acute promyelocytic leukemia and its treatment, which is one of the causes of high early mortality. the similarity of clinical manifestations of DS and other complications that may develop during acute promyelocytic leukemia therapy makes it difficult to diagnose ds. at the same time, untimely initiation of DS therapy with glucocorticosteroids can lead to the patient’s death. The only generally accepted risk factor for ds is initial leukocytosis. Specific markers confirming ds have not yet been found. A number of studies show that in patients with diagnosed DS, the expression of CD56, CD54, CD2, CD15, CD13, markers of immature granulocytes, β2-integrins was more often found on blast cells. exposure to tretinoin increased the expression of chemokine receptors, chemokines, and cytokines by blast cells and vascular endothelium. The influence exerted by atypical promyelocytes, due to their biological characteristics, on the coagulation system suggests an association between hemostasis state and ds development. However, the value of the above markers as predictors or signs of DS still needs to be tested, especially when it comes to non-chemotherapeutic treatment of acute promyelocytic leukemia with arsenic trioxide.
Glomerular filtration rate dynamics in patients with diffuse large B-cell lymphoma during induction immunopolychemotherapy
Authors: Nozdricheva A. S. , Lysenko I. B. , Guskova N. K. , Konovalchik M. A. , Maslov A. A. , Shalashnaya E. V.
Published: September 2023

Aim. To study the glomerular filtration rate (GFR) dynamics during induction immunopolychemotherapy (PCT) in patients with newly diagnosed diffuse large B-cell lymphoma.

   Materials and methods. The study included 39 patients with newly diagnosed diffuse large b-cell lymphoma who received specialized treatment in oncohematology department of national medical research centre for oncology (Rostov-on-Don). Patients underwent induction pct according to the R-CHOP (rituximab, doxorubicin, cyclophosphamide, vincristine, prednisolone) regimen with accompanying therapy (allopurinol). blood sampling was carried out at 0, 24, 48, 72, 120 hours and 21 days of the 1st PCT cycle. GFR was calculated using the SKD-epicre formula (chronic Kidney disease epidemiology collaboration creatinine-based). statistical data processing was carried out using the IBM SPSS statistics 23 program.

   Results. According to the gfr level before the start of chemotherapy (0 hours), the patients were divided into two groups: group a with GFR > 90 ml / min / 1.73 m2 and group b with GFR < 90 ml / min / 1.73 m2. In group a, there were no significant dynamic changes in the GFR level during PCT. Group B patients reacted more acutely to the administration of pct, which was manifested in an even greater decrease in the gfr level at 48 hours of PCT, and at 120 hours of PCT, the GFR approached the optimal values. on the 21st day from the start of the 1st pct course, the studied indicator returned to its initial values at 0 hour. further, the patients of these groups were divided into subgroups depending on the disease stage: group a consisted of 12 people with stages I–II and 15 people with stages III–IV. In group B, there were an equal number of patients with stages I–II and III–IV – 6 people. In group a, in patients with stages I–II and III–IV before the start of PCT (0 hours) and during PCT, there were no differences in the GFR level dynamics. In group B, patients with stages I-II and III–IV had similar GFR before the start of PCT, and during treatment, they reflected the previously noted general group trend in GFR level dynamics.

   Conclusion. The study found that in patients with initially low GFR level, a further, even more pronounced decrease in GFR during pct is observed. at the same time, the absence of significant differences in GFR level depending on disease stage allows us to conclude that the leading role is not so much the stage of the disease and tumor volume, but rather the initial functional status of the kidneys in the development of renal dysfunction in patients with diffuse large B-cell lymphoma during R-CHOP therapy.
Oncologic effectiveness of open partial vertical laryngectomy in the treatment of early glottic cancer
Authors: Karpenko A. V. , Sibgatullin R. R. , Boyko A. A. , Nikolayeva O. M.
Published: September 2023

Introduction. In the last decades, a discernable trend towards more frequent use of endoscopic laser surgery in operative treatment of cancer of the middle part of the larynx is observed. Smaller operative trauma, absence of tracheostomy, short hospitalization time, and better functional outcomes without compromising oncological outcomes are significant reasons for transition to endoscopic methods. However, local recurrence involving anterior commissure develops in every 4th patient. This can explain attempts to return to analysis of possibilities of a surgical alternative – open laryngectomies.

Aim. To retrospectively analyze the oncologic effectiveness of open partial vertical laryngectomy in the treatment of early glottic cancer.

Materials and methods. Results of treatment of 66 patients aged between 39 and 72 years (mean age 61.4 ± 8.7 years) with cT1–2N0m0 glottic cancer were analyzed. 33 patients had T1 tumors and 33 – T2. Anterior commissure was involved in 14 cases. Surgery was the only mode of treatment in 92.4 % of cases. Oncologic effectiveness was assessed with the following parameters: the rate of local, regional recurrence and kaplan–meyer overall survival.

Results. mean follow up was 58.64 ± 28.33 months (range 8–120 months). The rate of local recurrence for the whole cohort, T1 and T2 cases was 4.5; 3.0 and 6.1 %. The difference in local recurrence rate between T1 and T2 cases was statistically insignificant. The anterior commissure involvement did not affect negatively the rate of local recurrence. Regional recurrence was detected in 3 (4.5 %) patients. Larynx was preserved in 63 patients (92.4 %). 5 year overall survival was 86.12 %.

Conclusion. Open partial vertical laryngectomy is characterized by low rate of local recurrence and acceptable functional results. The method may be the optimal choice of treatment for certain subgroup of patients with more advanced and invasive tumors.
Prospects of epigenetic therapy of head and neck squamous cell carcinoma
Authors: Mustafin R. N.
Published: September 2023

Introduction. Head and neck squamous cell carcinoma is the 6th most common malignant tumor. It is characterized by immune response evasion and drug resistance. To stimulate antitumor immune response, antibodies against such cell cycle checkpoints as programmed cell death 1 (pD-1) and programmed death-ligand 1 (pD-L1) are used. However, effectiveness of monotherapy with these checkpoint inhibitors turned out to be low, and combinations with other antitumor drugs have high risk of adverse events.

Aim. To determine the most practical ways to influence epigenetic factors in treatment of head and neck squamous cell carcinoma.

Materials and methods. Scientific literature published between 2011 and 2022 and indexed in the eLIBRARY, Scopus, woS, NCBI databases (398 articles, of which 76 were used) was analyzed.

Results. prospects of development of epigenetic stimulation of expression of retroelements located in tumor genomes through inhibition of DNA methyltransferases, deacetylases and histone methyltransferases were considered. when retroelements are activated, their transcripts form double-stranded RNA stimulating T killers and interferon response (virus mimicry). for DNA methyltransferase inhibitors, restoration of tumor suppressor genes which are hypermethylated in squamous cell carcinoma is also observed. However, retroelement activation is a driver mechanism of carcinogenesis, and their nonspecific expression can lead to tumor progression and formation of secondary tumors. Therefore, in the virus mimicry method it is practical to use as targets microRNA complementary to retroelements which recruit epigenetic factors to their loci (RNA-directed DNA methylation), as well as antisense oligonucleotides against oncogenic microRNA associated with retroelements. These approaches allow to inhibit retroelements participating in carcinogenesis. Nonspecific method of retrotransposon activity suppression is being developed in antitumor therapy, but data show successful application of only reverse transcriptase inhibitors preventing insertions and progression of genomic instability. we have performed analysis of scientific literature on transposable elements-derived microRNA associated with head  and  neck  squamous  cell  carcinoma.  As  a  result,  31  microRNAs  were  identified,  derived  from:  LINE:  miR-1249, -151a, -211, -2355, -28, -31, -3144, -374a, -374b, -421, -450b, -511, -576, -577, -582, -708, -769, -887, -95; HERv: miR-1269a,  -1911,  -3200,  -495;  non-autonomous  SINE:  miR-335,  -342,  -378a,  -3934,  -487b;  DNA  transposons:  miR-224, -584, -652. These microRNAs can serve as the basis for epigenetic therapy of head and neck squamous cell carcinoma.
Pembrolizumab in treatment of head and neck squamous cell carcinoma: clinical cases and real-world practice
Authors: Alymov Yu. V. , Romanov I. S. , Ignatova A. V.
Published: September 2023

Recurrent and metastatic head and neck squamous cell carcinoma is a hard-to-treat pathology. median overall survival for standard chemotherapy regimens does not exceed 11 months. One of the factors decreasing treatment effectivenessis frequency of severe adverse events which are observed in every 2nd patient during standard therapy regimens. moreover,  even  if  notable  tumor  regression  is  achieved,  this  effect  is  transient.  Development  of  immunotherapy  drugs, namely pembrolizumab, helps solve these problems. Clinical trials and real-world use of the drug show that in the 1st and 2nd therapy lines for recurrent and metastatic head and neck squamous cell carcinoma, pembrolizumab allows to achieve persistent treatment response, increase overall survival, and decrease the frequency of adverse events.
Reactive astrocytes and glioblastoma: are there new targets for more effective antitumor therapy?
Authors: Tyagunova E. E. , Dobrokhotova V. Z. , Dushina A. O.
Published: September 2023

Introduction. Astrocytes in the brain of a healthy person perform a number of protective functions, contribute to maintaining the functional activity of neurons and their synapses. However, in some pathological conditions, they change their phenotype to a reactive one and can both remodel damaged areas and contribute to increased aggression and invasiveness of gliomas.

Aim. To comprehensively study the features of reactive astrocytes and the chemo- and radioresistance of gliomas associated with reactive astrocytes.

Materials and methods. The authors analyzed articles from the databases Elsevier, pubmed, Scopus, google Scholar, Embase, web of Science, The Cochrane Library, global Health, CyberLeninka and RSCI. when selecting articles, the indexing systems of journals and the citation of articles, the scientific novelty of research, the statistical significance of the results obtained in them were taken into account, publications with duplication of the results of previous studies were excluded. In the course of the study, data on the mutual influence of reactive astrocytes and glioma cells were systematized.

Results. Astrocytes of the brain of healthy people are highly variable and heterogeneous, which further complicates the interpretation of published studies. At the same time, reactive astrocytes contribute to an increase in the chemoresistance and radioresistance of gliomas of different degrees of malignancy. At the same time, the exact mechanisms for controlling the interaction between reactive astrocytes and glioma cells, which contributed to less progression and invasion of the tumor or its regression, have not yet been established. However, this direction is now actively developing and is promising due to the possibility of additional effects on gliomas.

Conclusion. At the moment, there is no effective treatment that can cope with gliomas, all existing treatment methods are aimed only at increasing the life expectancy of patients with gliomas. The results of recent studies suggest that, probably, the current insufficient effectiveness of chemo- and radiotherapy may be associated with a very close relationship between tumor cells and tumor-associated reactive astrocytes due to their mutual supportive effect. Therefore, the solution to the problem of incurable patients with gliomas may lie in a complex effect on both tumor cells and their microenvironment.
Spontaneous necrosis of parathyroid adenoma: clinical observation
Authors: Ilyin A. A. , Polkin V. V. , Isaev P. A. , Severskaya N. V. , Zhelonkina N. V. , Plugar A. K. , Ivanov S. A. , Kaprin A. D.
Published: September 2023

Fine needle aspiration biopsy is a routinely used technique to determine the nature of thyroid and parathyroid nodules. The complications and side effects associated with this procedure are minimal. At the same time, the histological alterations resulting from its use are well documented. Their range is quite w, however, from a clinical point of view, the most striking and catastrophic in their consequences are extensive heart attacks and necrosis. Such changes more often than in formations of a different morphological nature occur in tumors from oxyphilic cells. It should be noted that a lot of works devoted to post-biopsy changes are naturally focused on the morphological aspects of this problem, or are presented in the form of a presentation of individual clinical observations.

This report presents the observation of necrosis in the parathyroid adenoma, which developed before fine needle aspiration biopsy.
Capabilities of delayed microsurgical reconstruction in patients with squamous cell carcinoma of the buccal mucosa: clinical case
Authors: Guz A. O. , Garev A. V. , Fatkullin D. M. , Zaharov A. S. , Sokolova M. I.
Published: September 2023

Surgical treatment of patients with locally advanced squamous cell carcinoma of the oral mucosa is a complicated problem requiring maximal surgical radicality and, at the same time, single-stage reconstruction to preserve organ function and achieve acceptable esthetic results. One of modern reconstruction techniques is the use of free flaps. Application  of  this  technique  requires  microsurgical  skills  from  the  surgeon.  unfortunately,  it  is  not  always  possible to achieve the result after single-stage postoperative defect closure. Sometimes unforeseen complications are observed: necrosis of the moved flaps, formation of large postoperative defects, orostomas, pharyngostomas. In such cases, oncologists  face  a  more  complicated  problem:  defect  reconstruction  in  the  conditions  of  pronounced  scarring  process in the intervention area, development of post-radiation fibrosis and soft tissue edema.

The presented clinical case demonstrates the capabilities of repeat microsurgical reconstruction in patients with orostoma developed after unsuccessful primary reconstruction.
PV and QV analysis for finding the optimum location of FACTS device to investigate the effectiveness in KR power system using PSS/E
Authors:   University of Sulaimani, College of Engineering, Electrical Engineering Department, Abdullah Govand , Raafat Jwan ,   University of Sulaimani, College of Engineering, Electrical Engineering Department
Published: September 2023

This paper presents the effect of Static Synchronous Compensator (STATCOM) device in power system for power flow and voltage stability analysis. The stability of power system is most important evaluation that is needed to be considered under various contingency states. This paper presented Power-Voltage (PV) and Reactive power-Voltage (QV) analysis which have been widely used in steady state of power system in normal operating condition and gives important details about the loading of the system and voltage stability. The shunt and series compensation can be used to increase the voltage and flow in the power system. Kurdistan Region Power System (KRPS) used to verify the effectiveness and performance of STATCOM in power system. PSS/E proposed as power system software for KRPS. The result shows that the proposed Full Newton Raphson (FNR) method spends less execution time and the optimum placement for STATCOM for enhancing static voltage stability margin and improves the power transmission capability of the line is the 'weakest bus' of the system.
The Impact of Heritage Values on Public Perception of Architectural Conservation in Suleimani City
Authors:   University of Suleimani/College of Engineering/Architecture Department, Radha Tablo , Ali Alan ,   University of Suleimani/College of Engineering/Architecture Department
Published: September 2023

This paper aims to discover individuals’ perceptions of Suleimani city’s heritage buildings before and after architectural conservation, as part of a thesis about heritage awareness. Acknowledging that awareness is the ability to perceive and perception is affected by different heritage values that people attach to their built heritage. However, in the architectural conservation process in Suleimani city, some heritage values are neglected, or missing, due to various reasons, and this issue has affected public perception of heritage buildings. Therefore, in this paper, several heritage values have been selected to evaluate the public perception of built heritage in Suleimani city. Because understanding the built heritage and its impact on individual and community heritage awareness depends on how the community perceives and experiences its heritage. This study explores local perceptions of heritage buildings in Suleimani city by using the Semantic Differential Scale (SDS) measure, to analyze the responses of participants in a questionnaire survey. As well as, an evaluation has been made of selected heritage buildings to clarify the reflection of heritage values in Architectural conservation. Different results were found between perceived heritage values in the conserved buildings. By examining local perceptions of architectural conservation, this study contributes to the idea of the built environment's human-centeredness. Assuming that local views of the built heritage directly impact conservation efforts and heritage-driven solutions.
Categorizing Young Facebook Users Based On Their Differential Preference of Social Media Heuristics: A Q-Methodology Approach
Authors:   School of Science & Technology, RMIT University, Dang Duy Pham Thien , Nguyen Long ,   School of Communication & Design, RMIT University, Hoang Ai Phuong ,   School of Business & Management, RMIT University, Pittayachawan Siddhi ,   RMIT University, Akbari Mohammadreza ,   School of Business & Management, RMIT University, Nkhoma Mathews Zanda ,   School of Business & Management, RMIT University
Published: September 2023

Abstract Background: Social media have become an integral part of our modern society by providing platforms for users to create and exchange news, ideas, and information. The increasing use of social media has raised concerns about the reliability of the shared information, particularly information that is generated from anonymous users. Though prior studies have confirmed the important roles of heuristics and cues in the users’ evaluation of trustworthy information, there has been no research–to our knowledge–that categorized Facebook users based on their approaches to evaluating information credibility. Method: We employed Q-methodology to extract insights from 55 young Vietnamese users and to categorize them into different groups based on the distinct sets of heuristics that they used to evaluate the trustworthiness of online information on Facebook. Results: We identified four distinct types of young Facebook user groups that emerged based on their evaluation of online information trustworthiness. When evaluating online information trustworthiness on Facebook, these user groups assigned priorities differently to the characteristics of the online content, its original source, and the sharers or aggregators. We named these groups: (1) the balanced analyst, (2) the critical analyst, (3) the source analyst, and (4) the social network analyst. Conclusion: The findings offer insights that contribute to information processing literature. Moreover, marketing practitioners who aim to disseminate information effectively on social networks should take these user groups’ perspectives into consideration.
Review Manipulation: Literature Review, and Future Research Agenda
Authors:   Indian Institute of Management Raipur, Ansari Sana , Gupta Sumeet ,   Indian Institute of Management Raipur
Published: September 2023

Abstract Background: The phenomenon of review manipulation and fake reviews has gained Information Systems (IS) scholars’ attention during recent years. Scholarly research in this domain has delved into the causes and consequences of review manipulation. However, we find that the findings are diverse, and the studies do not portray a systematic approach. This study synthesizes the findings from a multidisciplinary perspective and presents an integrated framework to understand the mechanism of review manipulation. Method: The study reviews 88 relevant articles on review manipulation spanning a decade and a half. We adopted an iterative coding approach to synthesizing the literature on concepts and categorized them independently into potential themes. Results: We present an integrated framework that shows the linkages between the different themes, namely, the prevalence of manipulation, impact of manipulation, conditions and choice for manipulation decision, characteristics of fake reviews, models for detecting spam reviews, and strategies to deal with manipulation. We also present the characteristics of review manipulation and cover both operational and conceptual issues associated with the research on this topic. Conclusions: Insights from the study will guide future research on review manipulation and fake reviews. The study presents a holistic view of the phenomenon of review manipulation. It informs various online platforms to address fake reviews towards building a healthy and sustainable environment.
Challenges and Opportunities for Information Systems Research During and After Coronavirus
Authors:   Leavey School of Business, Santa Clara University, Lu Haibing , Liu Shan ,   School of Management, Xi’an Jiaotong University, Huang Wayne ,   College of Business, Southern University of Science and Technology, and School of Management, Xi’an Jiaotong University, Mou Jian ,   School of Business, Pusan National University
Published: September 2023

Abstract The COVID-19 pandemic has affected world-wide business and management immensely. Furthermore, challenges and opportunities for information systems research during and after coronavirus have emerged. To better understand the impacts of COVID-19 pandemic in the field of information systems (IS), and also as a part of the 2020 AIS SIG-ISAP Workshop on Information Systems in Asia Pacific (ISAP) being held prior ICIS-2020, we organized a panel to address this important issue with three distinguished information systems researchers. The panelists identified and discussed the challenges and opportunities for information systems research during and after Coronavirus. In addition, constructive suggestions for aspiring young scholars who aim to publish their works in top-tier IS journals have been proposed, which may benefit the IS community in large.
A Process Model for ERP Upgrade and Replacement Decisions
Authors:   Johannes Kepler University, Goman Maksim , Koch Stefan ,   Johannes Kepler Universitat
Published: September 2023

Abstract Background: This paper aims to develop an effective decision making (DM) process for ERP change or replacement. ERP in most organizations constitutes a key critical system of high complexity with many stakeholders. A major change activity for such a system therefore exposes an organization to great risks, and thus should be well organized. Method: A design science approach was chosen for this research. Based on a review of related literature and evidence of the DM process at different companies, a general process of DM for ERP upgrade was designed, and later evaluated and improved through a case study approach. Results: The decision process assumes a model with variables describing characteristics and performance of possible alternatives, and the decision is decomposed into steps with three loops that are executed iteratively. We believe that the findings and approach can be useful both for the immediate problem context and also for other IT-related DM problems. Conclusions: The main outcome is the new process of DM that includes several novel contributions: three main loops of DM, multiple repetition of loops, and possible returns to the starting point.
Train Your Frontline Personnel from Newbie to Master IT Users: A Three-Phase Longitudinal Experiment Focusing on Technology Compatibility
Authors:   Western Michigan University, Song, Jiahe , Zhu Suning ,   Trinity UniversityFollow
Published: September 2023

Abstract Background: Although many decision makers have recognized the importance of training to the success of their frontline personnel and organizations, hidden technological compatibility issues can lead to training failure especially when different generations, or iterations, of hardware and software are involved. In this study, we aimed to investigate the impact of different levels (high vs. low) of compatibility between software and hardware on frontline trainees’ gained understanding of the related IT. Method: Grounded in experiential learning, we designed a three-stage training experiment that involved the use of cloud-based geographical information systems and radio-frequency identification devices. The experiment included compatibility between hardware and software, a longitudinal learning simulation, and a real-world frontline scenario. 33 students enrolled in an introductory course from a major business school participated in the training, and their responses during each training stage were collected. Results: The results revealed that compatibility is a critical factor in determining the success or failure of an IT training program. High compatibility helps frontline trainees accumulate useful IT knowledge over time, while low compatibility tends to reduce their learning outcome on the related IT over time. Conclusions: This study is one of the few that focus on IT training issues relating to a neglected but important user group – frontline workers. Studying hardware-software compatibility of the target technology expands the understanding of factors that influence IT training outcomes. This research highlights the strategic role of well-articulated IT compatibility in frontline IT training.
An Empirical Examination of the Use of IS-enabled Sustainability Initiatives across the Integrated Sustainability Framework
Authors:   Shippensburg University, Dao Viet T. , Abraham Thomas ,   Kean University
Published: September 2023

Abstract Background: Using the Resource Based View (RBV) and the Integrated Sustainability Framework (ISF) as theoretical foundation, this study proposes and empirically examines hypotheses on how different types of IS-enabled sustainability initiatives are used to enable environmental and social sustainability in the four quadrants of the ISF. Method: The study uses a mixed-method approach, combining multiple-case study and non-parametric statistical analysis (Friedman test). IS-enabled sustainability initiatives were collected from Global Reporting Initiative (GRI) reports of six leading global sustainability companies across three industries with different levels of IS/IT use intensity during 2009-2015 period. Results: The study finds empirical quantitative and qualitative support for the proposed hypotheses. In different quadrants of the ISF, companies were found to use different types of IS-enabled sustainability initiatives in different patterns to enable sustainability strategy. Conclusions: The study opens the IS box to provide further theoretical and empirical insights on how companies combine IS and business resources to develop different types of IS-enabled sustainability initiatives to help them address sustainability (both environmental and social) across the ISF. The study is among early IS research that adopts GRI reports as data source and presents a method for extracting GRI data for IS and sustainability research. Researchers and practitioners can both find the study’s findings instructive.