bluuebunny/crossref_metadata_2025 huggingface dataset:
Peculiarities of Sustainable Cultural Development: A Case of Dark Tourism in Lithuania
Authors: Jureniene Virginija , Radzevicius Martynas
Published: June 2022

The aim of this article is to reveal the connection and significance of the concepts of dark tourism and sustainable tourism for the sustainable development of tourism, especially for regional tourism growth. The article discusses the theoretical aspects of dark tourism and details the aspects of this tourism industry as part of cultural tourism. The article also analyses principles and models of sustainable tourism development, with a stronger focus on the integrated development paradigm. As a relatively significant part of the research and analysis of sustainable tourism is more focused on the challenges posed by global mass tourism, this article focuses on the issues of sustainable development of niche tourism in relation to regional tourism. The article presents the analysis of Lithuanian dark tourism resources, presents the most common dark (dissonant) heritage objects, as well as the evaluation of resources according to the spectrum of dark tourism and the comparative analysis of the country’s most popular dark tourism objects from the point of view of sustainable tourism. A qualitative study revealed that regional tourism in Lithuania (especially niche, such as dark tourism) lacks integrity among different stakeholders, especially in involving the local community in the processes of cultural heritage protection and cultural tourism development and in developing more intensive links with the private sector. On the other hand, the analysis also revealed that there is an ambiguous public opinion regarding the dark heritage, which does not contribute to the sustainable development of tourism and the actualization of such heritage. The article also discusses the models of sustainable development of dark tourism and invites to discuss how to encourage greater public involvement in the development of dark tourism as part of cultural tourism, so that the principle of sustainable tourism does not remain an empty declaration.
Long-Term Assessment of Contemporary Ion-Releasing Restorative Dental Materials
Authors: Marovic Danijela , Par Matej , Posavec Karlo , Marić Ivana , Štajdohar Dominik , Muradbegović Alen , Tauböck Tobias T. , Attin Thomas , Tarle Zrinka
Published: June 2022

The objective was to evaluate new commercially available ion-releasing restorative materials and compare them to established anti-cariogenic materials. Four materials were tested: alkasite Cention (Ivoclar Vivadent) in self-cure or light-cure mode, giomer Beautifil II (Shofu), conventional glass-ionomer Fuji IX (GC), and resin composite Tetric EvoCeram (Ivoclar Vivadent) as a control. Flexural strength, flexural modulus, and Weibull modulus were measured one day, three months, and after three months with accelerated aging in ethanol. Water sorption and solubility were evaluated for up to one year. Degree of conversion was measured during 120 min for self-cured and light-cured Cention. In this study, Beautifil II was the ion-releasing material with the highest flexural strength and modulus and with the best resistance to aging. Alkasite Cention showed superior mechanical properties to Fuji IX. Weibull analysis showed that the glass-ionomer had the least reliable distribution of mechanical properties with the highest water sorption. The solubility of self-cured alkasite exceeded the permissible values according to ISO 4049. Degree of conversion of light-cured Cention was higher than in self-cure mode. The use of alkasite Cention is recommended only in the light-cure mode.
Optimizing Parametric Factors in CIELAB and CIEDE2000 Color-Difference Formulas for 3D-Printed Spherical Objects
Authors: He Ruili , Xiao Kaida , Pointer Michael , Melgosa Manuel , Bressler Yoav
Published: June 2022

The current color-difference formulas were developed based on 2D samples and there is no standard guidance for the color-difference evaluation of 3D objects. The aim of this study was to test and optimize the CIELAB and CIEDE2000 color-difference formulas by using 42 pairs of 3D-printed spherical samples in Experiment I and 40 sample pairs in Experiment II. Fifteen human observers with normal color vision were invited to attend the visual experiments under simulated D65 illumination and assess the color differences of the 82 pairs of 3D spherical samples using the gray-scale method. The performances of the CIELAB and CIEDE2000 formulas were quantified by the STRESS index and F-test with respect to the collected visual results and three different optimization methods were performed on the original color-difference formulas by using the data from the 42 sample pairs in Experiment I. It was found that the optimum parametric factors for CIELAB were kL = 1.4 and kC = 1.9, whereas for CIEDE2000, kL = 1.5. The visual data of the 40 sample pairs in Experiment II were used to test the performance of the optimized formulas and the STRESS values obtained for CIELAB/CIEDE2000 were 32.8/32.9 for the original formulas and 25.3/25.4 for the optimized formulas. The F-test results indicated that a significant improvement was achieved using the proposed optimization of the parametric factors applied to both color-difference formulas for 3D-printed spherical samples.
RETRACTED: Numerical Case Study of Chemical Reaction Impact on MHD Micropolar Fluid Flow Past over a Vertical Riga Plate
Authors: Goud B. , Reddy Yanala , Alshehri Nawal , Jamshed Wasim , Safdar Rabia , Eid Mohamed , Bouazizi Mohamed
Published: June 2022

The purpose of this article is to investigate the mass and heat transport phenomena associated with micropolar fluid flow created by a vertically stretched Riga surface. This is constructed using an array of irregular electrodes and permanent magnets that are oriented spanwise. Additionally, we investigate the particles’ micro rotational impacts. Furthermore, the flow behaviour of the modeled problem has been numerically calculated with bvp4c solver and the obtained results are presented graphically. Numerical data are used to illustrate physical parameters such as skin friction, Nusselt, and Sherwood numbers. For precise values of different flow parameters, the characteristics of fluid velocity, angular velocity, temperature, and concentration gradients are investigated graphically. The flowing parallel to the Riga plate in a positive x–path is aided by Lorentz forces introduced into the flowing simulation by the electro-magnetic poles of the Riga plate, which produces a rapidity greater than the inner speed. It is confirmed that the numerical calculations fit well with the results of earlier published investigations. Due to the participation of the Riga plate, the updated Hartmann number has a considerable effect on flow profiles.
Study on the Cutting Damage Mechanism of Aramid Honeycomb Based on the Progressive Damage Model
Authors: Yang Yuxing , Bao Yongjie , Wang Jinlong , Chen Chen
Published: June 2022

A progressive damage model for aramid honeycomb cutting was proposed to reveal its cutting damage mechanism. It established the relationship between the mesoscale failure modes and the macroscale cutting damage types of the aramid honeycomb. The proposed model addressed the material assignment problem of impregnated honeycomb by developing a material calculation method that simulates the real manufacturing process of the aramid honeycomb. Cutting experiment of aramid honeycomb specimen was conducted concerning on the cutting forces response and cutting damages, which validated that the proposed method was effective for investigating the cutting process and mechanism for the aramid honeycomb. Predicted cutting mechanism results show that: (a) cutting process of the aramid honeycomb can be divided into three stages with four characteristic states—initial state, cut-in state, cut-out state and final state; (b) cell wall bending in the cutting direction relieves the cutting force, and strong plasticity of the aramid fiber makes it hard to break, which lead to uncut fiber and burr damages; (c) using sharp tip cutting tool to reduce cutting force and bonding both top and bottom of the honeycomb to make it stiffer are beneficial to obtain good cutting quality with less damages.
Effect of Aging and Cooling Path on the Super β-Transus Heat-Treated Ti-6Al-4V Alloy Produced via Electron Beam Melting (EBM)
Authors: Carrozza Alessandro , Marchese Giulio , Saboori Abdollah , Bassini Emilio , Aversa Alberta , Bondioli Federica , Ugues Daniele , Biamino Sara , Fino Paolo
Published: June 2022

This work focuses on the effect of different heat treatments on the Ti-6Al-4V alloy processed by means of electron beam melting (EBM). Super β-transus annealing was conducted at 1050 °C for 1 h on Ti-6Al-4V samples, considering two different cooling paths (furnace cooling and water quenching). This heat treatment induces microstructural recrystallization, thus reducing the anisotropy generated by the EBM process (columnar prior-β grains). Subsequently, the annealed furnace-cooled and water-quenched samples were aged at 540 °C for 4 h. The results showed the influence of the aging treatment on the microstructure and the mechanical properties of the annealed EBM-produced Ti-6Al-4V. A comparison with the traditional processed heat-treated material was also conducted. In the furnace-cooled specimens consisting of lamellar α+β, the aging treatment improved ductility and strength by inducing microstructural thickening of the α laths and reducing the β fraction. The effect of the aging treatment was also more marked in the water-quenched samples, characterized by high tensile strengths but limited ductility due to the presence of martensite. In fact, the aging treatment was effective in the recovery of the ductility loss, maintaining high tensile strength properties due to the variation in the relative number of α/α’ interfaces resulting from α’ decomposition. This study, therefore, offers an in-depth investigation of the potential beneficial effects of the aging treatment on the microstructure and mechanical properties of the EBM-processed super β-transus heat-treated Ti-6Al-4V alloy under different cooling conditions.
Radiological Hazards and Natural Radionuclide Distribution in Granitic Rocks of Homrit Waggat Area, Central Eastern Desert, Egypt
Authors: Lasheen El Saeed R. , Azer Mokhles K. , Ene Antoaneta , Abdelwahab Wael , Zakaly Hesham M. H. , Awad Hamdy A. , Kawady Nilly A.
Published: June 2022

Natural radioactivity, radiological hazard, and petrological studies of Homrit Waggat granitic rocks, Central Eastern Desert, Egypt were performed in order to assess their suitability as ornamental stone. On the basis of mineralogical and geochemical compositions, Homrit Waggat granitic rocks can be subdivided into two subclasses. The first class comprises granodiorite and tonalite (I-type) and is ascribed to volcanic arc, whereas the second one includes alkali-feldspar granite, syenogranite, and albitized granite with high-K calc alkaline character, which is related to post-orogenic granites. 238U, 226Ra, 232Th, and 40K activities of natural radionuclides occurring in the examined rocks were measured radiometrically using sodium iodide detector. Furthermore, assessment of the hazard indices—such as: annual effective dose (AED) with mean values (0.11, 0.09, 0.07, 0.05, and 0.03, standard value = 0.07); gamma radiation index (Iγ) with mean values (0.6, 0.5, 0.4, 0.3, and 0.14, standard value = 0.5); internal (Hin) with mean values (0.6, 0.5, 0.4, 0.3, and 0.2, standard value = 1.0); external (Hex) index (0.5, 0.4, 0.3, 0.24, and 0.12, standard value = 1.0); absorbed gamma dose rate (D) with mean values (86.4, 75.9, 53.5, 43.6, and 20.8, standard value = 57); and radium equivalent activity (Raeq) with mean values (180, 154, 106.6, 90.1, and 42.7, standard value = 370)—were evaluated with the knowledge of the natural radionuclides. The result of these indices falls within the acceptable worldwide limits. Therefore, we suggest that these rocks are safe to be used in industrial applications.
Call the Eckols: Present and Future Potential Cancer Therapies
Authors: Monteiro Pedro , Lomartire Silvia , Cotas João , Marques João C. , Pereira Leonel , Gonçalves Ana M. M.
Published: June 2022

In recent years, an increased interest in marine macroalgae bioactive compounds has been recorded due to their benefits to human health and welfare. Several of their bioactivities have been demonstrated, such as anti-inflammatory, antioxidant, anticarcinogenic, antibacterial and antiviral behavior. However, there still lacks a clear definition regarding how these compounds exert their bioactive properties. Of all the bioactive compounds derived from marine macroalgae, attention has been focused on phenolic compounds, specifically in phlorotannins, due to their potential for biomedical applications. Phlorotannins are a diverse and wide group of phenolic compounds, with several structural variations based on the monomer phloroglucinol. Among the diverse phlorotannin structures, the eckol-family of phlorotannins demonstrates remarkable bioactivity, notably their anti-tumoral properties. However, the molecular mechanisms by which this activity is achieved remain elusive and sparse. This review focuses on the described molecular mechanisms of anti-tumoral effects by the eckol family of compounds and the future prospects of these molecules for potential application in oncology therapies.
Diagnosis and treatment of ventricular arrhythmias in the practice of a family doctor
Authors:   FSBEI HE Volgograd State Medical University, Skvortsov Vsevolod Vladimirovich , Skvortsova Ekaterina Mikhailovna ,   FSBEI HE Volgograd State Medical University, Saprykina Marina Anatolievna ,   FSBEI HE Volgograd State Medical University
Published: June 2022

Ventricular arrhythmia (VA) is a disorder in the frequency, rhythm, and sequence of myocardial excitation-contraction caused by an impulse source that is localized below the bundle of His: in the region of the branches of the bundle of His, in the Purkinje fibers or directly in the muscular thickness of the heart ventricles (ectopic focus of excitation). Thus, at first the myocardium of that ventricle in the conducting system of which an ectopic focus of excitation has arisen is excited, then, the impulse passes to the other branch of the His bundle along the anastomoses and causes excitation of the other ventricle. Ventricular arrhythmia (VA) has many causes, and each of them is of significant importance. Often, ventricular arrhythmia (VA) occurs in healthy people, with an accidental ECG recording; as a rule, these are young and middle-aged people. The incidence of this pathology is increasing every year in the world, despite good drug support. Ventricular arrhythmia (VA) is predominantly observed in the developed countries of the world, where there are prerequisites for this (stress, overwork, high workload).
May 5 — International Day of the Midwife
Authors:   SBHI RR Kerch City Children's Hospital, Rybachok Oksana Aleksandrovna
Published: June 2022

For the first time, the idea of celebrating the International Day of the Midwife was announced in the Netherlands during the International Congress on Midwifery in 1987. Today this date is celebrated in more than 50 countries of the world, including Russia. It is the midwife’s hands that are the first to touch each of us at the moment of birth; not only the health of a young mother and child, but sometimes even their lives depend on the midwives’ competent and selfless work. This date is not linked to the birthday of any famous obstetrician-gynecologist, or to any other significant event. Nevertheless, hundreds and thousands of representatives of this wonderful profession gather on this day to take part in conferences and symposiums, hold round tables and open days in medical universities and colleges. It doesn't matter where the midwife works — in an antenatal clinic or a maternity hospital, in a medical unit or a feldsher-obstetric station, she has one task — to protect the health of the mother and the unborn child.
Medical workers during the pandemic of the new coronavirus infection COVID-19 and risk factors for professional burnou
Authors:   SBEI HE «Samara State Medical University» of the Ministry of Health of the Russian Federation (FSBEI HE SamGMU of the Ministry of Health of Russia), Ostryakova N. A. , Babanov S. A. ,   FSBEI HE «Samara State Medical University» of the Ministry of Health of the Russian Federation
Published: June 2022

The article presents the results of a questionnaire survey of medical workers. The questionnaire allows you to assess the attitude of medical workers to the situation related to the new coronavirus infection. A survey was conducted of 186 outpatient medical workers providing medical care in conditions of an increased epidemic threshold for ARVI, influenza and the new coronavirus infection COVID-19 aged 25 to 64 years and 195 medical workers of hospitals providing medical care in their main profile, working as usual and periodically identifying patients with COVID-19 between the ages of 25 and 64. The data obtained indicate the emergence of new factors associated with the new coronavirus infection, which may affect the «emotional burnout» in medical workers.
Quality of life in vibration disease from exposure to local and general vibration
Authors:   FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation, Babanov Sergey Anatolievich , Tatarovskaya N.A. ,   SBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation, Kiryushina T.M. ,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation
Published: June 2022

Under the influence of industrial vibration, there is a change in all indicators characterizing the quality of life, regardless of the type of production activity. When comparing the parameters of the quality of life of patients with vibration disease and people not affected by vibration, a significant difference was found, indicating a significant influence of the disease on the physical and mental status of the patient. When comparing patients with vibration disease from exposure to local vibration and patients with vibration disease from exposure to general vibration it was revealed that the quality of life of the latter is worse, although significant differences are observed only on the scales of "physical functioning" and "physical component of health". This can be explained by more pronounced manifestations of vibration disease in this group of patients. with vibration disease from exposure to local vibration and patients with vibration disease from exposure to general vibration it was revealed that the quality of life of the latter is worse,although significant differences are observed only on the scales of "physical functioning" and "physical component of health". This can be explained by more pronounced manifestations of vibration disease in this group of patients.
The specificity and complexity of the implementation of the awareness-raising process in modern conditions
Authors:   Institute of Fundamental and Applied Research, Moscow,, Kostina Anna Vladimirovna
Published: June 2022

The article shows that awareness-raising work is currently developing in complicated conditions associated with a number of factors and conditions, including crisis phenomena in the economy and the labor market, as well as restrictions caused by the pandemic. In this difficult situation, socialization processes that are essential for young people take place. The author presents the characteristics of upbringing as a specific process, paying attention to the fact that such factors as biological heredity, social environment, culture, individual and group experience have a special influence on personality development. Heredity determines the person’s temperament and his/her physiological characteristics; however, personal characteristics of an individual, his/her culture, experience, and value system are not associated with inherited traits, but acquired in the process of socialization. Here the leading factors are the following: the influence of the external environment, which has an active, but not purposeful impact on a person, and education as a purposeful and conscious effect on a person, aimed at forming a number of qualities and characteristics that meet the needs of a particular society at a certain stage of its development. The material of the article may be of interest to employees involved in the organization of the awareness-raising process at the higher educational institution during extracurricular time, as well as for all teachers for whom the awareness-raising component is part of pedagogical activity and is inseparable from the process of transferring knowledge.
Mass culture as a form of production of images, ideas and meanings: artistry and propaganda
Authors:   Institute of Fundamental and Applied Research, Moscow University for the Humanities, Makarevich Eduard Fedorovich , Karpukhin Oleg Ivanovich ,   Institute of Fundamental and Applied Research, Moscow University for the Humanities
Published: June 2022

In a liberal democratic society, the development of mass culture is determined by the market. The authors show that the social order comes from the management of companies that produce "cultural products", as well as from publishing concerns, film and television corporations, and music firms. They finance only those projects that satisfy the company, while producers select only those scripts and promote those projects and performers that satisfy the tastes and attitudes of social groups in society. Prestigious awards in any field of art (for example, the Oscar Academy Award) are given to the authors of those works that meet the ideological guidelines and criteria for artistic expression. And every award is also a kind of benchmark for artists. The article shows that mass culture acts as a form of production of images, ideas and meanings.
Chinese distance learning: advantages and disadvantages
Authors:   FSAEI HE Ural Federal University named after the first President of Russia B.N. Yeltsin, Zavyalova Natalya Alekseevna , Schemerova Anastasiya Igorevna ,   Nizhny Novgorod Dobrolyubov State Linguistic University
Published: June 2022

Distance learning has become part of our reality. Online educational platforms provide a wide range of online courses, including Chinese language courses. The method of teaching Chinese has its own specifics, not to mention the fact that Chinese itself is the most difficult foreign language in the world. The article discusses the advantages and disadvantages of learning Chinese in a remote format.
Populations sizes and leaf morphology of the Welsh endemics Sorbus cambrensis Welsh Whitebeam and Sorbus stenophylla Llanthony Whitebeam (Rosaceae)
Authors: Lepší Martin , Rich Timothy C.G.
Published: June 2022

The distribution and population sizes of Sorbus cambrensis (Welsh Whitebeam) and S. stenophylla (Llanthony Whitebeam) (Rosaceae) are revised based on field surveys. About 224 trees of S. cambrensis occur in eight populations/subpopulations (including in the Llanthony Valley), and about 96 trees of S. stenophylla occur in five populations/subpopulations. Morphological analysis of leaves confirmed the two species were different and showed some variation within each species.
The typification of the Linnaean name Papaver medium (Papaveraceae) published in Flora Anglica
Authors: Iamonico Duilio
Published: June 2022

The typification of the Linnaean name Papaver medium is discussed. A Morison’s illustration is designated as the lectotype, lacking specimen of original material. The identity of the type is widely discussed reaching to the conclusion that P. medium is a synonym of P. dubium subp. dubium.
ISOLASI DAN IDENTIFIKASI Streptomyces sp. PADA KOLAM TANAH DI DESA TENGGUR TULUNGAGUNG JAWA TIMUR
Authors: Prasetya Didik
Published: June 2022

Tenggur Village, Rejotangan District, Tulungagung Regency is a village where the majority of its residents work as fish farmers. Currently, one of the diseases that attack fish is thought to be caused by infection with Aeromonas hydrophila bacteria, the fish's body parts will bleed, especially the chest, abdomen and at the base of the fins, and the fish will die even though the pond is well maintained. Fish disease control is currently still using chemicals so that the impact of beneficial bacteria will be destroyed in the pond environment and residues of compounds in fish that will be harmful to health if consumed. Streptomyces bacteria are bacteria that are able to produce enzymes and antibiotics that can be used as biocontrol agents for several diseases caused by bacteria. The purpose of this study was to isolate and identify Streptomyces bacteria from soil ponds in Tenggur Tulungagung Village, East Java. Isolation was carried out using the serial dilution method. Streptomyces were isolated from an earthen pond with a depth of 15 cm from the soil surface and planted on Yeast Extract Malt Agar (ISP4) media. The growing colonies were observed macroscopically and microscopically, as well as biochemical tests using the Guide to the Classification and Identification of the Actinomycetes and Their antibiotics from Lechevalier and Waksman (1973). The results showed 4 isolates of Streptomyces sp.1, Streptomyces sp.2, Streptomyces sp.3, Streptomyces sp.4. The four isolates will later be tested against Aeromonas hydrophyla bacteria, which is the cause of Motile Aeromonas septicemia.
ANALISIS KUALITAS FISIK DAN BAKTERIOLOGI AIR BERSIH PERUSAHAAN DAERAH AIR MINUM DESA SELANBAWAK TABANAN
Authors: Jirna I Nyoman
Published: June 2022

ABSTRACTIntroduction: PDAM water Selanbawak village is water used by people at Selanbawak Village for their daily needs such as drinking water. Drinking water qualify the requirements of physics, microbiology, chemistry and radioactivity (Permenkes 492 of 2010). In 2020 there occur a landslide disaster which cause damage to pipes, causing health problems such as diarrhea. Methods: The research used quantitative with a descriptive design using the simple random sampling technique of 179 populationsThe study was conducted to determine the quality of clean water from PDAM based on physical and bacteriological parameters from January to April 2021 at the homes of the residents of Banjar Selanbawak kaja, then physical and bacteriological examinations using the Most Probable Number (MPN) method were carried out at  Panureksa Utama Laboratory. Results: The results of physical quality from 15 samples (100%) qualify the health requirements based on Permenkes RI No. 492 / MENKES / PER / IV / 2010. Meanwhile, examination of Coliform bacteria (67%) with the category fulfilling the health requirements and examination of Escherichia coli bacteria (73%) with the category fulfilling the requirements based on Permenkes RI No. 492 / MENKES / PER / IV / 2010. Conclusion: Based on these results, it can be concluded that most of the PDAM water still qualify health requirements.Keywords: Selanbawak, physical, bacteriology, PDAM water
ENGARUH PEMBERIAN EKSTRAK UBI JALAR (Ipomoea batatas L.) VARIETAS UNGU KULTIVAR GUNUNG KAWI TERHADAP KADAR GAMMA – GT PADA TIKUS WISTAR PUTIH JANTAN (Rattus norvegicus strain wistar) YANG DIBERI DIET ATEROGENIK
Authors: Adiputra C. Dr. A A Ngurah Wisnu
Published: June 2022

Hyperlipidemia is a condition in which increased levels of serum cholesterol or triglycerides above the normal limits due to excessive consumption of fat, causing fat intake and an overhaul becomes unbalanced. Purple sweet potato contains anthocyanins, flavonoids, and fiber Anthocyanins and flavonoids can lower triglyceride levels. This study aims to determine the effect of extract of sweet potato (Ipomoea batatas L.) cultivars Purple varieties Gunung Kawi Gamma GT levels Against White Male Wistar rats were given the atherogenic diet. This study was designed using pure experimental analytic methods Randomized Post Test Only Control Group Design. Population of this research is a white male Wistar rats (Rattus norvegicus Wistar) in healthy condition are 2-3 months old weighing approximately 150-250 grams. Number of samples of 5 mice in each treatment group so that the total number of samples required are as many as 25 rats.The results showed that the extract of purple sweet potato (Ipomoea batatas L.) cultivars Gunung Kawi proved to have an influence on a reducing Gamma-glutamyl transferase levels in male rats (Rattus norvegicus) strain wistar were given atherogenic diet with doses of about 20 mg/kg.
PERBANDINGAN IDENTIFIKASI Toxoplasma gondii MENGGUNAKAN METODE POLYMERASE CHAIN REACTION (PCR) DAN METODE ENZYME LINKED FLUORESCENT ASSAY (ELFA)
Authors: Mushlih Miftahul , Nurfitriana Alifia , Ningsih Kurnia Wahyu , Azizah Nurul , Arian Nia Lukita
Published: June 2022

Toxoplasmosis is an infectious disease that does not show specific symptoms. This study aimed to determine the differences results of T. gondii detection in human blood using the PCR (polymerase chain reaction) with the ELFA (Enzym Linked Fluorescent Assay) method. The research was done by descriptive exploratory methods. Samples taken from 9 West Sumatra Pramita Clinics Laboratory and 1 person came from Sidoarjo as a control. Data analyzes was conducted by a chi-square test with a 95% confidence level. In the ELFA method detects IgG Anti-Toxoplasma. Whereas the molecular test detects  B1 gene target. The serological test was able to detect 9 patients of toxoplasmosis and 1 patient was negative/ control. The molecular test showed a specific band with 195 bp in length. The accuracy of the molecular test was 77% (T count (4.4) T table (3.84). Based on the results its can be concluded that there a difference in identification between the PCR method and the ELFA method.
Gambaran kolesterol total pada lansia di Puskesmas I Denpasar Selatan
Authors: Swastini I Gusti Agung Ayu Putu
Published: June 2022

background Total Cholesterol is the amount of cholesterol carried In all cholesterol carrying particle In the blood including HDL, LDL, and VLDL. THR elderly will experience the aging process and decreased physiology function change which can lead tO reduced activity of the receptors of controlling the amount of choledterol In the body. The normal value of total cholesterol level is normal 200 mg/dl, high limit 200-239 mg/dl, and high 240 mg/dl. Risk factors can affect total cholesterol level are age gender, BMI, and blood pressure. The purpose of this study was tO determine to description of total cholesterol levels In elderly. The research method uses discritive research with purpisive sampling method involving 115 respondents take using secondary data for the elderly at Puskesmas I South Denpasar. THR results showed That most elderly respondents who experienced an increase total cholesterol were female as many as 26 people (22,6%) the age group 65-74 years as many as 18 people (15,7%), In the normal BMI category as many as 26 people (22,6%), and normal bolos pressure as many as 25 people (21,7%), high limit total cholesterol levels as many 45 people(31,9%), and high total cholesterol levels as many as 45 people (31,9%).
FORMULASI JAGUNG MANIS SEBAGAI MEDIA ALTERNATIF PERTUMBUHAN BAKTERI PATOGEN
Authors: Prasetya Yulianto Ade
Published: June 2022

Background: Sources of carbohydrates and proteins to support bacterial growth are available abundance in nature with very affordable prices, including sweet corn. Aims: This research to determine growth of pathogenic bacteria Escherichia coli and Staphylococcus aureus by using sweet corn as an alternative medium with different formulations. Method: The method used was total plate count (TPC) with sweet corn variations used were 1g, 2g, 3g, 4g, and 5g and colony forming units (CFU) were calculated after being incubated for 24 hours at 37C. Result: The result showed that E. coli and S. aureus was able to grow optimally in the variation of 5g with a growth of respectively 46,7 x 107 CFU/mL and 112,7 x 107 CFU/ mL. This research is expected to be used as an alternative medium for routine microbial growth for the purpose of detecting contamination in human biological samples as well as for food and beverage products. Keywords: Sweet corn, Alternative medium, Escherichia coli, Staphylococcus aureus
PARA ALÉM DOS MUROS DA ESCOLA: A CORRESPONDÊNCIA INTERESCOLAR
Authors: Yamashita Dayane Cristina Moraes , Lima Cinthia Vieira Brum
Published: June 2022

Relato referente à apresentação no 22º Cole da prática da correspondência interescolar, técnica da Pedagogia Freinet, com alunos dos anos iniciais do Ensino Fundamental. O trabalho permitiu aos alunos o aperfeiçoamento da expressão escrita, percebendo-se autores de textos significativos.
Indicators of nonspecific resistance of the organism in patients with destructive forms of erysipelas
Authors: Vasylevskaya L. A.
Published: June 2022

Purpose of the study. to evaluate the indicators of nonspecific resistance of the organism in patients with destructive forms of erysipelas.

 Materials and methods. 114 case histories of patients who were hospitalized in the center of purulent - septic surgery of KNP "City Hospital G3" in Zaporozhye for the period 2019-2020 were analyzed.

According to the forms of the disease, patients were distributed as follows: erythematous - 24 (21.0%) - control group; bullous - 28 (24.6%), phlegmonous form - 48 (42.1%), necrotic - 14 (12.3%). Among the latter, 10 patients were aggravated by sepsis. 6 patients died, mortality was 60%.

Results. Complementary activity of blood serum in patients with destructive forms of erysipelas in a favorable course of the disease is significantly increased, which is not observed in patients with sepsis. A significant increase in the HCT- test provides information on the degree of functional irritation of peripheral blood neutrophils under the influence of pathogens. But its increase almost 2 times until the moment of clinical recovery indicates the ongoing stimulation of phagocytic cells of peripheral blood, which caused changes in the metabolic profile of cast iron. The decrease in phagocytic activity in patients with sepsis may be due to a defect in the absorption capacity of polymorphonuclear leukocytes, and its progressive decrease, to some extent, may be a marker of adverse disease outcome.

Conclusion. The degree of changes in the indicators of nonspecific resistance of the organism makes it possible to assess the reserves of the immune response, to determine the intensity and dynamics of destructive forms of erysipelas.
IS CANCER SCREENING DURING WAR?
Authors: Kovalov O. O.
Published: June 2022

The problem of cancer during the war and after the end of hostilities in Ukraine will worsen. According to some estimates, cancer incidence and mortality in our country may exceed the pre-war level.

Along with exposure to carcinogens, important factors that influence the development of cancer in people after the war are the massive demographic movements of the population, which increase the risk of transmission of oncogenic bacteria and viruses, such as Helicobacter pylori, Epstein-Barr virus, hepatitis B and C viruses and human papilloma virus. Sexually transmitted infections, including as a result of violence against civilians, occupy a special place in this series.

Today in Ukraine there is not only an urgent need for oncological screening, but all the possibilities for this. Self-sampling technology for cervical cancer screening is indispensable and has no alternative. They allow for mass surveys of the population, refugees and displaced persons affected by hostilities, without diverting health care resources for this.

The Qvintip test from the Swedish company Aprovix can be used not only to detect oncogenic human papillomavirus DNA strains, but also for PCR diagnosis of most sexually transmitted infections - bacterial vaginosis, candidiasis, gonorrhea, chlamydia, detection of trichomonas, ureaplasma, mycoplasma, treponema.

Screening in Ukraine is financed by the non-governmental non-profit organization of the charitable Foundation "World Against Cancer", created in the first days of the war.
Effectiveness of Treatment of Chronic Pelvic Pain Caused by Disharmonal Uterine Pathology in Women of Fertile Age
Authors: Можейко Л.Ф. , Маркова Е.Д.
Published: June 2022

Хроническая тазовая боль – одна из серьезнейших проблем женского здоровья, свидетельствующая о наличии заболеваний, неблагоприятным образом отражающихся на репродуктивном здоровье и качестве жизни. Среди причин обращения к гинекологу 10% занимает хроническая тазовая боль, обусловленная дисгормональной патологией матки.В статье приведен анализ патофизиологических и патоморфологических основ развития тазовой боли, а также особенностей восприятия боли у женщин с дисгормональной патологией матки.Характер, морфология и механизмы возникновения боли различаются в зависимости от патологии: при лейомиоме характер болей зависит от расположения миоматозного узла, плотности распределения нервных волокон в псевдокапсуле миомы и прилегающем миометрии. Причины возникновения боли также связывают с механическим сдавлением нервных сплетений, перерастяжением брюшины и ишемией узла.Показана эффективность лекарственного средства природного происхождения миомин в терапии доброкачественной опухоли матки, сочетанной с неатипической гиперплазией эндометрия, клинически проявляющейся развитием симптома хронической тазовой боли. Установлены положительная динамика снижения проявлений симптомов патологии, удобство и безопасность применения лекарственных средств, а также регрессивные изменения в процессе лечения. Установлена целесообразность использования предложенных схем терапии.

Chronic pelvic pain is one of the most serious women’s health problems, indicating the presence of diseases that adversely affect reproductive health and quality of life. Among the reasons for visiting a gynecologist, 10% is occupied by chronic pelvic pain caused by disharmonious pathology of the uterus.The article provides an analysis of the pathophysiological and pathomorphological foundations of the development of pelvic pain, as well as the characteristics of pain perception in women with disharmonic pathology of the uterus.The nature, morphology and mechanisms of pain differ depending on the pathology: in leiomyoma, the nature of pain depends on the location of the myomatous node, the distribution density of nerve fibers in the pseudocapsule of the fibroids and the adjacent myometrium. The causes of pain are also associated with mechanical compression of the nerve plexuses, hyperextension of the peritoneum and node ischemia.The effectiveness of the natural drug myomine in the treatment of benign uterine tumors combined with non-atypical endometrial hyperplasia, which is clinically manifested by the development of a symptom of chronic pelvic pain, has been shown. A positive trend in reducing the manifestations of symptoms of pathology, the convenience and safety of the use of drugs, as well as regressive changes in the treatment process were established. The expediency of using the proposed therapy regimens has been established.
The Role of Viruses of the Herpesviridae Family in the Formation of Prenatal Infection in Premature Infants
Authors: Жевнеронок И.В. , Лямцева А.К. , Костюк С.А. , Полуян О.С. , Руденкова Т.В. , Козыревич М.А.
Published: June 2022

Одной из ведущих медико-социальных проблем перинатологии являются внутриутробные инфекции, среди которых особое внимание уделяется инфекции, вызываемой герпес-вирусами. Герпес-вирусные инфекции обладают склонностью к тяжелому течению, часто имеют последствия и снижают качество жизни детей. Они также занимают ведущее место среди причин преждевременных родов, мертворождаемости, могут вызывать тяжелые врожденные инфекции с неврологическими нарушениями в неонатальном и постнеонатальном периоде.Цель. Проанализировать роль герпес-вирусов, поражающих нервную систему, таких как Herpes simplex virus types 1 и 2, Epsteina – Barr virus, Cytomegalovirus и Human herpesvirus type 6, в формировании пренатальной патологии у недоношенных детей. Материалы и методы. Нами проанализированы отечественные и зарубежные публикации о роли герпес-вирусов в поражении нервной системы при внутриутробных инфекциях у новорожденных, систематизированы вопросы диагностики герпесвирусных инфекций в детском возрасте.Результаты и обсуждение. Освещены механизмы передачи герпес-вирусов, поражающих нервную систему (Herpes simplex virus types 1 и 2, Epsteina – Barr virus, Cytomegalovirus и Human herpesvirus type 6), особенности патологии, вызываемой данной группой вирусов; клинические проявления; особенности патогенеза данных вирусных инфекций у недоношенных детей.

One of the leading medical and social problems of obstetrics and perinatology is intrauterine infections, among which special attention is paid to the infection caused by herpes viruses. Herpesvirus infections tend to a protracted, often severe course, which is accompanied by a decrease in the quality of life.Purpose. To analyze the role of herpes viruses affecting the nervous system, such as: Herpes simplex virus types 1 and 2, Epsteina – Barr virus, Cytomegalovirus and Human herpesvirus type 6 in the formation of prenatal pathology in premature babies.Materials and methods. We analyzed domestic and foreign publications on the role of herpesviruses in lesions of the nervous system in intrauterine infections in newborns, systematized the issues of diagnosing herpesvirus infections in childhood.Results and discussion. The article presents the mechanisms of transmission of herpes viruses affecting the nervous system (Herpes simplex virus types 1 and 2, Epsteina – Barr virus, Cytomegalovirus and Human herpesvirus type 6), the features of the pathology caused by this group of viruses; clinical manifestations; features of the pathogenesis of these viral infections in premature infants.
Dysmenorrhea in Combination with Endometriosis in Adolescence and Early Reproductive Age
Authors: Иванишкина-Кудина О.Л.
Published: June 2022

Распространенность дисменореи среди женщин молодого возраста и подростков крайне высока. Своевременная диагностика первичной и вторичной форм дисменореи в молодом возрасте позволяет выбрать обоснованную патогенетическую терапию прогестероном, которая даст возможность совместить высокую эффективность с одновременным снижением нежелательных медикаментозных и гормональных нагрузок при длительной терапии заболевания.

The prevalence of dysmenorrhea among young women and adolescents is extremely high. Diagnosis of primary and secondary forms of dysmenorrhea at a young age makes it possible to choose a reasonable pathogenetic progesterone therapy, which will combine high efficiency and at the same time reduce unwanted drug and hormonal during long-term therapy of the disease.
Features of the Prolonged Course of Exudative Otitis Media. Literature Review
Authors: Кротов С.Ю.
Published: June 2022

В данной статье обзорного характера отмечено, что экссудативный средний отит по своей продолжительности подразделяется на абортивное течение, заканчивающееся самостоятельно либо в течение месяца после проведения традиционных консервативных процедур, и пролонгированное течение, требующее значительных усилий для остановки патологической секреции слизистой оболочки среднего уха. Приведены этиологические аспекты (вирусная инфекция, аллергия, особенности анатомического строения среднего уха, генетическая предрасположенность), а также основные патогенетические механизмы, способствующие неблагоприятному, длительному течению экссудативного среднего отита. Представлены варианты традиционных и новых способов консервативного лечения, базирующиеся на использовании современных физических технологий (электрофорез, ультрафонофорез). Указаны их положительные и отрицательные стороны. Отмечено, что в последние годы изменилось отношение к тактике хирургического лечения экссудативного среднего отита в сторону уменьшения показаний к мирингостомии на ранней стадии заболевания. Тем не менее при пролонгированном течении экссудативного среднего отита, несмотря на большое количество отрицательных оценок данного метода, мирингостомия все же продолжает оставаться довольно частой лечебной процедурой. В заключении автор делает акцент на необходимости дальнейших исследований по разработке новых консервативных методов лечения пациентов с учетом пролонгированного течения данного заболевания.

An overview article, in which it is noted that exudative otitis media in terms of its duration is subdivided into sports, ending on its own, or within a month after traditional conservative procedures, and prolonged course, requiring significant efforts to stop the pathological secretion of the mucous membrane of the middle ear. The etiological aspects (viral infection, allergies, features of the anatomical structure of the middle ear, genetic predisposition), as well as the main pathogenetic mechanisms that contribute to the unfavourable, long-term course of exudative otitis media are presented. Variants of traditional and new methods of conservative treatment based on the use of modern physical technologies (electrophoresis, ultraphonophoresis) are presented. Their positive and negative sides are indicated. It is noted that in recent years, the attitude towards the tactics of surgical treatment of exudative otitis media has changed towards a decrease in the indications for myringostomy at an early stage of the disease. Nevertheless, with a prolonged course of exudative otitis media, despite a large number of negative statements about her, it still continues to be a fairly frequent treatment procedure. In conclusion, the author emphasizes the need for further research to develop new conservative methods of treating patients with a prolonged course.
Montelukast in the Treatment of Adenoids
Authors: Хоров О.Г.
Published: June 2022

В работе представлены материалы по применению препарата монтелукаст при лечении аденоидов. В Республике Беларусь зарегистрирован препарат монтелукаста Синглон (Гедеон Рихтер, Венгрия). Рассмотрены источники из ресурсных баз. Оценка публикаций позволила сделать вывод об эффективности и безопасности лечения монтелукастом гипертрофии глоточной миндалины у детей. Монтелукаст может быть рекомендован для лечения гипертрофии глоточной миндалины (аденоидов). Назначение препарата целесообразно в следующих случаях: при наличии показаний к аденотомии имеется отказ родителей или опекунов от операции; при наличии противопоказаний к операции у ребенка с аденоидами; при наличии гипертрофии глоточной миндалины, но при отсутствии явных показаний к аденотомии; при рецидиве аденоидов после операции; для профилактики рецидива гиперплазии лимфоидной ткани после аденотомии в послеоперационном периоде.

The paper presents materials on the use of the drug montelukast in the treatment of adenoids. Montelukast Singlon (Gedeon Richter, Hungary) is registered in the Republic of Belarus. Sources from resource bases discussed. Evaluation of publications made it possible to draw a conclusion about the efficacy and safety of treatment with montelukast for hypertrophy of the pharyngeal tonsil in children. Montelukast may be recommended in the treatment of hypertrophy of the pharyngeal tonsil (adenoids). Indications for the use of the drug is advisable in the following cases: if there are indications for adenotomy, there is a refusal of parents or guardians from the operation; if there are contraindications to surgery in a child with adenoids; in the presence of hypertrophy of the pharyngeal tonsil, but in the absence of clear indications for adenotomy; with recurrence of adenoids after surgery; for the prevention of recurrence of hyperplasia of the lymphoid tissue after adenotomy in the postoperative period.