bluuebunny/crossref_metadata_2025 huggingface dataset:
El futuro de la integración regional y el vínculo con el cambio de orientación política en América Latina
Authors: Menendez Delgado Erick Rodolfo , Cevallos Zambrano Doris Patricia
Published: December 2018

América Latina es una región del globo terráqueo que comparte características comunes en términos culturales, sociales, religiosos y productivos; que han provisto las facilidades para establecer relaciones diplomáticas entre sus países lo que ha dado lugar a importantes procesos de integración que se han visto influenciados por la orientación política que han tenido las naciones que la conforman, pasando de modelos neoliberales a esquemas socialistas representados por gobierno de derecha e izquierda respectivamente. El objetivo del presente trabajo fue analizar la situación histórica y actual de los acuerdos regionales, para poder prospectar escenarios que pueda tener la integración regional en el futuro, para ello se realizó una revisión bibliográfica y se utilizó la herramienta metodológica de prospectiva que permitió orientar posibles escenarios de futuro. El resultado más importante del documento, indica una relación evidente entre los procesos de integración y la orientación política por la que han atravesado los pueblos de América Latina, lo que permitió establecer un conjunto de posibles escenarios que pueda tener la integración futura de América Latina.  

Palabras claves: integración, competitividad, acuerdos comerciales, prospectiva.
Percepciones de los docentes del idioma Inglés sobre inclusión educativa
Authors: Loor Aldas Marjorie Del Rocío , Ortiz David Mónica Ruth , Aucapiña Sandoval Sara Esther
Published: December 2018

La mayoría de docentes de inglés enfrentan día a día dificultades en el proceso de  enseñanza-aprendizaje de este idioma en las aulas con alumnos regulares. Por cuanto, es fácil deducir las diversas situaciones que podrían presentarse al trabajar en las aulas de clase con estudiantes con necesidades educativas especiales (NEE).

El propósito de este estudio es develar las percepciones de los docentes del Idioma inglés sobre la educación inclusiva y conocer el impacto y las implicaciones que rodean el proceso formativo de estudiantes NEE.

Este estudio investigó las creencias, pensamientos, el conocimiento, y expectativas que los docentes tienen sobre educación inclusiva. Los objetivos educativos que pueden y no pueden cumplir en totalidad con los estudiantes NEE. En total participaron ocho docentes de inglés de la sección matutina de la Unidad Educativa Fiscal Amarilis Fuentes Alcívar,  a quienes se les aplicó un cuestionario online de ocho preguntas. El método empleado en este estudio fue un enfoque cuantitativo descriptivo debido a la naturaleza del tema.

PALABRAS CLAVE: necesidades educativas especiales, educación inclusiva, percepción.
Análisis de los problemas institucionales que inciden en la enseñanza del idioma Inglés en las Unidades Educativas Península De Santa Elena y Colegio Militar Eugenio Espejo
Authors: Loor Zambrano Kléber Walter , Almeida Briones Xavier Antonio , González Reyes Sara Dolores , Tomalá Jessica , Cevallos Salazar Jorge Esteban
Published: December 2018

El presente estudio estableció como objetivo analizar los problemas institucionales en las dimensiones de infraestructura, políticas educativas y organización académica en el aprendizaje del idioma inglés de los estudiantes de la Unidad Educativa Península de Santa Elena y la Unidad Educativa experimental Colegio Eugenio Espejo, periodo 2017-201, para su cumplimiento se aplicó la investigación exploratoria e investigación de campo con enfoque cuantitativo, cualitativo y mixto. Los instrumentos de recolección de datos utilizados fueron las fichas de observación, encuesta y entrevistas, durante el período de aplicación de estos instrumentos se pudo observar la infraestructura de las instituciones, de los espacios abiertos y recreativos, de las aulas de clase, de sus espacios deportivos, rutas de evacuación, iluminación, ente otras. Además, se determinó que existe una inadecuada implementación de las políticas educativas, y organización académica las cuales han influido para que el proceso de enseñanza-aprendizaje del idioma inglés no se desarrolle apropiadamente; esto se relaciona con insuficiente presencia de materiales didácticos además de no contar con la conectividad que es fundamental para el manejo y utilización de recursos tecnológicos. La importancia de este diagnóstico radica fundamentalmente en la necesidad de mejorar el proceso de enseñanza-aprendizaje en las Unidades Educativas objeto de esta investigación. Se espera que el presente diagnóstico pueda ser una herramienta orientadora que contribuya al mejoramiento del sistema educativo, especialmente en la enseñanza del idioma inglés
Gestión de talento y desarrollo de competencias de personas con discapacidad
Authors: Paredes Floril Priscilla Rossana
Published: December 2018

El presente artículo pretende demostrar que la gestión del talento humano permite el desarrollo de competencias cardinales en personas con discapacidad que laboran en las empresas de la provincia del Guayas- Ecuador. La metodología aplicada se enfoca en un estudio cuantitativo. El tipo de investigación utilizada es aplicada, y el tipo de estudio es no experimental con un diseño correlacional, transversal”. Se utilizó la técnica de la encuesta, a través del instrumento cuestionario, para recolectar datos cualitativos Los resultados obtenidos demuestran que la Gestión del Talento Humano presenta una correlación positiva alta con el Desarrollo de Competencias cardinales en personas con discapacidad.
Herramientas TIC: Uso de los mapas conceptuales y mentales para potenciar el Aprendizaje en asignaturas aplicadas a la carrera de Comunicación.
Authors: Cortez Paola Elizabeth , González Santos Milton , Molina Benavides Lilian Susana , Iza Espinoza Luis , Cochea Panchana Gerzon
Published: December 2018

Este artículo es una aproximación preliminar de una investigación inacabada, referida a las herramientas TIC y el uso de los mapas conceptuales y mentales para potenciar el aprendizaje en las asignaturas aplicadas a los estudiantes de Comunicación en la Universidad Estatal Península de Santa Elena, Ecuador. El estudio permitió interpretar los sentidos y significados desde las voces y haceres de los propios docentes de la asignatura, para determinar si efectivamente utilizaban estrategias didácticas relacionadas con estas herramientas en su área disciplinar. Develar el significado de las acciones de los docentes en el ámbito de sus experiencias cotidianas y en plena intersubjetividad con sus pares académicos, lleva a la investigadora a asumir una postura intersubjetiva y dialógica, para develar los nudos verbales e interpretar una realidad relacionada con el saber y hacer pedagógico en ese proceso de interacción. Se siguió el método fenomenológico-hermenéutico. Se seleccionaron cinco docentes del área disciplinar y para recabar la información se utilizó la observación participante y la entrevista en profundidad. Posteriormente, se procedió a categorizar, codificar, triangular e interpretar la información preliminar. Entre algunos hallazgos se resalta: ausencia formativa en los procesos pedagógicos referidos a las TIC, poca valoración al uso de las herramientas TIC, limitado uso de mapas conceptuales y mentales en el área disciplinar. Las reflexiones en este aspecto, se ofrecen a futuros investigadores acerca de un camino transitado para seguir indagando e incursionando en torno a este escenario.
Evaluación de dietas balanceadas en cerdos de engorde en la comuna Bellavista del Cerro, Parroquia Julio Moreno, provincia de Santa Elena
Authors: Villacrés Matías Julio , Villón Gabino Edison , Ortega Maldonado Lourdes Hilda
Published: December 2018

La producción de cerdos en el Ecuador no se ha desarrollado en su totalidad, los sistemas de explotaciones intensivos giran en torno a las grandes empresas debido a que estos elaboran sus productos para su línea de alimentación; otras empresas elaboran balanceados para la comercialización, imposibilitando al pequeño productor adquirir este tipo de insumos por los precios de venta al público, los cuales optan por alimentar a los animales de manera tradicional. El presente proyecto permitió evaluar dietas balanceadas artesanales frente a balanceados comerciales en cerdos de engorde, procurando obtener los mismos parámetros productivos a menor costo; repercutiendo con esto en la mejora de la rentabilidad. Para el presente ensayo se evaluaron 16 cerdos destetados de raza Large White midiendo variables como la ganancia de peso (GP), conversión alimenticia (CA), alimento consumido (AC), relación benéfico costos (R-B/C) de cada tratamiento; para las dietas balanceadas artesanales se emplearon materias primas que se encuentran en la zona. Los datos fueron evaluados cada quince días, siendo el T1 el mejor en todas las variables, teniendo GP promedio quincenal de 9.91 kg, CA de 2.44, AC de 24.18 kg y R-B/C de $ 0.36, mientras que T3 a pesar de presentar parámetros productivos inferiores al T2 tubo mejor R-B/C de $ 0.23. Finalmente, con las dietas balanceadas artesanales no se logró igualar los parámetros productivos de las dietas balanceadas comerciales pero se obtuvo mayor rentabilidad, como lo demuestra el T3 frente al T2, por lo que se recomienda seguir evaluando otras dietas artesanales frente a otras comerciales existentes en la zona.
Aplicación de una torre empacada como purificador de gases de chimenea en la industria minera de El Oro, cantón Ponce Enríquez, Ecuador
Authors: Quinde Alvear Angel Giovanny
Published: December 2018

El mercurio es considerado un metal altamente tóxico, en el campo de la minería una de las principales formas de exposición al mercurio (Hg), es por vía respiratoria por la presencia de vapores liberados por incineradores en la extracción de oro. El presente estudio fue realizado con el fin de tomar medidas para evitar que estos gases se propaguen en el ambiente, a fin de evitar la contaminación de aire. La minería aurífera históricamente se ha constituido en una fuente de ingreso para las provincias del austro ecuatoriano (Azuay, El Oro, Loja, Zamora Chinchipe, etc.); esta investigación se la realizó en la compañía minera Austro Gold Cia. Ltda. en la provincia del Azuay, cantón Ponce Enríquez, parroquia Villa Rica, donde se construyó y posteriormente se aplicó la Torre Empacada como un método para disminuir estas emisiones de gases de chimenea. La metodología de medición se aplicó de forma experimental, se tomaron 3 muestreos de dos mediciones, uno en el ducto de entrada y otro en el ducto de salida de los gases de la Torre Empacada, mientras se probaban tres condiciones de operación diferentes. Las Torres Empacadas resultaron ser una excelente alternativa para la absorción de los gases producidos en la quema de la amalgama, al ser equipos empleados en la industria para poner en contacto una fase liquida con una gaseosa y se logró retener el 95% de los vapores de mercurio producidos en dicho proceso.
Composición, abundancia y distribución de Diatomeas en dos localidades de la provincia del Guayas entre octubre 2013 y febrero 2014.
Authors: Solano Vera Yadira , Caregua Villegas Carlos , Duque Marín Richard , Gonzalez Banchon Tanya
Published: December 2018

El presente trabajo se desarrolló en dos localidades de la Provincia del Guayas  entre octubre y febrero 2014. El objetivo de esta investigación   fue comparar la  composición, abundancia  y distribución  de diatomeas centrales  en las aguas estuarinas de la parroquia Posorja   y en el Cantón General Villamil  Playas de influencia oceánica. Los arrastres superficiales se realizaron quincenalmente a bordo de una embarcación un motor de 75 HP a una velocidad de 2 nudos, en un tiempo de 5 minutos de recorrido por cada estación a 1 milla de la orilla del mar. En  total se identificaron 71   especies en las que predominan las Diatomeas Centrales   con 60 especies  y se  registraron 11 especie de Diatomeas Pennales, la especie    con    mayor    densidad. Chaetoceros coarctatus, mayor densidad poblacional con 15576 cel. 100m3, correspondiendo al 12,80% en las dos áreas muestreadas de un total de 36 muestras colectadas. Mediante el índice de Shannon – Wiener  se muestra una similitud entre estaciones. En  Posorja hubo irregularidad en todas las estaciones, coincidente con el índice de Simpson que  registró que no hay similitud entre estaciones. La abundancia y distribución corresponde al 51% de las Diatomeas del orden Centrales en Posorja  en tanto el 49% concierne a General Villamil.
Análisis situacional y diagnóstico de enfermedades crónicas en habitantes de una población rural de Taura
Authors: Fiallos Sanchez Stefanny , Escobar-Segovia Kenny , Aguirre Morocho Ivonne
Published: December 2018

La salud es un derecho garantizado por la Constitución Política de la República del Ecuador, que debe ser tratado e identificado en cada región. Actualmente, las enfermedades crónicas están en un proceso evolutivo en la sociedad, debido a las condiciones alimenticias, socioeconómicas y al sedentarismo de la población. La presente investigación busca integralmente identificar las causas de las enfermedades crónicas tales como hipertensión, diabetes y dislipidemias en el recinto ex Cooperativa Taura perteneciente al cantón Naranjal en la provincia del Guayas, efectuando un control periódico de la medicación y el tratamiento que debe realizar cada habitante para controlar su enfermedad crónica en la unidad médica del Ministerio de Salud. Se utilizó la observación no estructurada al momento de aplicar el cuestionario de preguntas a los encuestados, siendo la  poblacion de estudio 26 familias, realizado en cada domicilio del sector.  Por lo tanto, mediante esta investigación se identificó las causas de las enfermedades crónicas y se estableció metodologías para ayudar a mejorar los tratamientos de salud en la población para implementar los respectivos controles y prevención y así reducir el aumento de dichas enfermedades.
Técnicas quirúrgicas para ruminotomía con fistulación ruminal en cabras
Authors: Chávez García Debbie , Lozano Nestor Acosta , Varas-Aguillón Jefferson , Macias-Muñoz Anggy , Pilay-Malave Michelle , Ramirez Malave Carlos , Vera-Vera Joseph
Published: December 2018

El presente trabajo formó parte del proyecto de investigación Calidad Nutricional, degradabilidad ruminal y digestibilidad fecal de Moringa oleifera. Se fistularon caprinos machos criollos de 24 a 36 meses, peso promedio 35kg, evaluados clínicamente sin presentar síntomas patológicos. Previo a la cirugía las cabras fueron sometidas a ayuno de sólidos y líquidos, en el pre operatorio se utilizó Meloxican, Penicilina G Procaína, acepromacina y Ketamina, además se realizó una sedación regional con epidural craneal y bloqueos de los nervios paravertebrales izquierdo T13, L1, L2 con lidocaína al 2 %. La ruminotomía es la apertura del rumen donde se aplicaron dos técnicas de fistulación ruminal, en ambas se colocó al animal de cubito lateral izquierdo para incidir en la zona del ijar, superado el plano subcutáneo divulsionando las fibras de los músculos oblicuo abdominal externo, interno y el transverso abdominal,  peritoneo para luego exponer el rumen e incidir en él y colocar la fistula ruminal fijándola  con una sutura de jareta para introducirlo a la cavidad abdominal en ambas técnicas. En la primera, se unieron con hilos de sutura superficie del rumen, el peritoneo y los músculos mencionados para posterior cierre de la piel. En la segunda técnica solo se dejó que los músculos se replieguen a su posición inicial finalmente, se hizo acercamiento subcutáneo y sutura de piel con hilo nylon. A los 7 días postcirugía se determinó que los procesos de cicatrización y adherencia de los músculos y el rumen fueron similares en ambas técnicas.
Native Ion Mobility Mass Spectrometry: when Gas Phase Ion Structures Depend on the Electrospray Charging Process
Authors: Khristenko Nina A. , Amato Jussara , Livet Sandrine , Pagano Bruno , Randazzo Antonio , Gabelica Valerie
Published: December 2018

Ion mobility spectrometry (IMS) has become popular to characterize biomolecule folding. Numerous studies have shown that proteins that are folded in solution remain folded in the gas phase, whereas proteins that are unfolded in solution adopt more extended conformations in the gas phase. Here, we discuss how general this tenet is. We studied single-stranded DNAs (human telomeric cytosine-rich sequences with CCCTAA repeats), which fold into an intercalated motif (i-motif) structure in a pH-dependent manner, thanks to the formation of C‒H+‒C base pairs. As i-motif formation is favored at low ionic strength, we could investigate the ESI-IMS-MS behavior of i-motif structures at pH ~5.5 over a wide range of ammonium acetate concentrations (15 mM to 100 mM). The control experiments consisted of either the same sequence at pH ~7.5, wherein the sequence is unfolded, or sequence variants that cannot form i-motifs (CTCTAA repeats). The surprising results came from the control experiments. We found that the ionic strength of the solution had a greater effect on the compactness of the gas-phase structures than the solution folding state. This means that electrosprayed ions keep a memory of the charging process, which is influenced by the electrolyte concentration. We discuss these results in light of the analyte partitioning between the droplet interior and droplet surface, which in turn influences the probability of being ionized via a charged residue pathway or a chain extrusion pathway.
Azide-Based High-Energy Metal-Organic Framework with Enhanced Thermal Stability
Authors: Chi-Duran Ignacio , Manquian Carolina , Serafini Daniel , enriquez javier , Herrera Felipe , Singh Dinesh Pratap
Published: December 2018

We report the synthesis of Zn(C6H4N5)N3, a new three-dimensional metal-organic framework (MOF) that exhibits strong energetic properties with high thermostability. The compound is synthesized by the hydrothermal method with in situ ligand formation under controlled pH. Structural characterization is carried out by single-crystal XRD, elemental analysis and FTIR. Energetic properties are obtained from TGA and DSC measurements. This novel MOF structure is thermally stable up to 345 C and its heat of detonation is -400$ kJ/g. The measured velocity and pressure of detonation are 4.66 km/s and 9.99 GPa, respectively.
Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles
Authors: Chen Wei , Cheng ChiAn , Cosco Emily , Ramakrishnan Shyam , Lingg Jakob , Bruns Oliver , Zink Jeffrey I. , Sletten Ellen
Published: December 2018

Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-aggregation offers a means to transform stable, near-infrared (NIR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that hollow mesoporous silica nanoparticles (HMSNs) can template the J-aggregation of NIR fluorophore IR-140 to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging in vivowith 980 nm excitation.
Long Time-Scale Atomistic Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition
Authors: Liao Qinghua , Lüking Malin , Krüger Dennis M. , Deindl Sebastian , Elf Johan , Kasson Peter M. , Kamerlin Shina Caroline Lynn
Published: December 2018

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Helvetica Neue'} Recent years have witnessed an explosion of interest in computational studies of DNA binding proteins, including both coarse grained and atomistic simulations of transcription factor-DNA recognition, in order to understand how these transcription factors recognize their binding sites on the DNA with such exquisite specificity. The present study performs μs-timescale all-atom simulations of the dimeric form of the lactose repressor (LacI), both in the absence of any DNA, and in the presence of both specific and non-specific complexes, considering three different DNA sequences. We examine, specifically, the conformational differences between specific and non-specific protein-DNA interactions, as well as the behavior of the helix-turn-helix motif of LacI when interacting with the DNA. Our simulations suggest that stable LacI binding occurs primarily to bent A-form DNA, with a loss of LacI conformational entropy and optimization of correlated conformational equilibria across the protein. In addition, binding to the specific operator sequence involves a slightly larger number of stabilizing DNA-protein hydrogen bonds (in comparison to non-specific complexes), that may account for the experimentally observed specificity for this operator. In doing so, our simulations provide a detailed atomistic description of potential structural drivers for LacI selectivity.
Fungal Indole Alkaloid Biogenesis Through Evolution of a Bifunctional Reductase/Diels-Alderase
Authors: Dan Qingyun , Newmister Sean A. , Klas Kimberly R. , Fraley Amy E. , McAfoos Timothy J. , Somoza Amber D. , Sunderhaus James D. , Ye Ying , Shende Vikram V. , Yu Fengan , Sanders Jacob N. , Brown W. Clay , Zhao Le , Paton Robert S. , Houk K. N. , Smith Janet L. , Sherman David H. , Williams Robert M.
Published: December 2018

Prenylated indole alkaloids isolated from various fungi possess great structural diversity and pharmaceutical utility. Among them are the calmodulin inhibitory malbrancheamides and paraherquamides, used as anthelmintics in animal health. Herein, we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through complementary approaches. These include a biomimetic total synthesis to access the natural alkaloid and biosynthetic intermediates in racemic form, and in vitro enzymatic reconstitution that provides access to the natural antipode (+)-malbrancheamide. Reductive cleavage of a L-Pro-L-Trp dipeptide from the MalG nonribosomal peptide synthetase (NRPS) followed by reverse prenylation and a cascade of post-NRPS reactions culminates in an intramolecular [4+2] hetero-Diels-Alder (IMDA) cyclization to furnish the bicyclo[2.2.2]diazaoctane scaffold. Enzymatic assembly of optically pure (+)-premalbrancheamide involves an unexpected zwitterionic intermediate where MalC catalyzes enantioselective cycloaddition as a bifunctional NADPH-dependent reductase/Diels-Alderase. Crystal structures of substrate and product complexes together with site-directed mutagenesis and molecular dynamics simulations demonstrated how MalC and PhqE, its homolog from the paraherquamide pathway, catalyze diastereo- and enantioselective cyclization in the construction of this important class of secondary metabolites.
Bioinspired Syntheses of Herqulines B and C from Cyclodipeptide Mycocyclosin
Authors: Zhu Xu , McAtee Christopher C. , Schindler Corinna
Published: December 2018

A bioinspired approach for the syntheses of herqulines B and C is reported that takes advantage of an Ltyrosine-derived diketopiperazine, a mycocyclosin analog, as a synthetic precursor. The strategy relies on a series of consecutive reductions to adjust the mycocyclosin oxidation state to that observed in the herquline class of natural products. The strained and distorted L-tyrosine-based biaryl system characteristic for mycocyclosin is selectively converted to the 1,4-diketone structural motif common to the herqulines via initial hypervalent iodine-mediated dearomatization and a subsequent directed Birch reduction, enabled by an intramolecular H-source. The piperazine oxidation state is accessible in an iron-catalyzed reduction of the diketopiperazine precursor.
Spin-Crossover Phenomena of Ni(cyclam)I2 Complex: Magnetostructural Correlations in Two Polymorphs
Authors: Horii Yoji , Kanegae Yuki , Takahashi Kiyonori , Fuyuhiro Akira , Suzuki Hal , Nakano Motohiro
Published: December 2018

Two crystal polymorphs of Ni(cyclam)I2 (cyclam = 1,4,8,11-tetraazacyclotetradecane) were identified by X-ray structural analysis and their magnetic properties were investigated. Gradual spin-crossover behaviors were found in both polymorphs. Entropy differences between high- and low-spin states obtained by assuming the spin equilibrium model reflected subtle difference of the coordination environment of nickel(II) ion in two polymorphs.
Polycomb and Notch signaling regulate cell proliferation potential duringCaenorhabditis eleganslife cycle
Authors: Coraggio Francesca , Püschel Ringo , Marti Alisha , Meister Peter
Published: December 2018

Stable cell fate is an essential feature for multicellular organisms in which individual cells achieve specialized functions.Caenorhabditis elegansis a great model to analyze the determinants of cell fate stability because of its invariant lineage. We present a tractable cell fate challenge system that uses the induction of fate-specifying transcription factors. We show that wild-type differentiated animals are highly resistant to fate challenge. Removal of heterochromatin marks showed marked differences: the absence of histone 3 lysine 9 methylation (H3K9) has no effect on fate stability, whereas Polycomb homologmes-2mutants lacking H3K27 methylation terminally arrest larval development upon fate challenge. Unexpectedly, the arrest correlated with widespread cell proliferation rather than transdifferentiation. Using a candidate RNAi larval arrest-rescue screen, we show that the LIN-12Notchpathway is essential for hyperplasia induction. Moreover, Notch signaling appears downstream of food-sensing pathways, as dauers and first larval stage diapause animals are resistant to fate challenge. Our results demonstrate an equilibrium between proliferation and differentiation regulated by Polycomb and Notch signaling in the soma during the nematode life cycle.
A C/EBPα–Wnt connection in gut homeostasis and carcinogenesis
Authors: Heuberger Julian , Hill Undine , Förster Susann , Zimmermann Karin , Malchin Victoria , Kühl Anja A , Stein Ulrike , Vieth Michael , Birchmeier Walter , Leutz Achim
Published: December 2018

We explored the connection between C/EBPα (CCAAT/enhancer-binding protein α) and Wnt signaling in gut homeostasis and carcinogenesis. C/EBPα was expressed in human and murine intestinal epithelia in the transit-amplifying region of the crypts and was absent in intestinal stem cells and Paneth cells with activated Wnt signaling. In human colorectal cancer and murine APCMin/+polyps, C/EBPα was absent in the nuclear β-catenin–positive tumor cells. In chemically induced intestinal carcinogenesis, C/EBPα KO in murine gut epithelia increased tumor volume. C/EBPα deletion extended the S-phase cell zone in intestinal organoids and activated typical proliferation gene expression signatures, including that of Wnt target genes. Genetic activation of β-catenin in organoids attenuated C/EBPα expression, and ectopic C/EBPα expression in HCT116 cells abrogated proliferation. C/EBPα expression accompanied differentiation of the colon cancer cell line Caco-2, whereas β-catenin stabilization suppressed C/EBPα. These data suggest homeostatic and oncogenic suppressor functions of C/EBPα in the gut by restricting Wnt signaling.
Scenario Analysis of the Russian Forex Market Development Strategies
Authors: Zvonova E. A.
Published: December 2018

The subject of the research is the foresight into development strategies of the foreign exchange sector of the Russian financial market under the new geo-economic conditions and in the context of the international monetary system reform and sanctions on Russian transactions in the international financial market. The relevance of the problem is caused by the ruble volatility and strong fluctuations in the values of macroeconomic variables after 2014. The purpose of the research was to develop a scenario model for the development of the Russian forex market for the next three years based on three scenario forecasts: optimistic, pessimistic and conservative. A scenario model of the Russian foreign exchange market development was built by superimposing scenarios of the national economy development on the forex market development scenarios along with assessment of the possible impact of the forex market development on other national financial market segments. The model is based on international macroeconomic variables statistics, the state of Russia’s payment balance and also on a comparative analysis of the development indices of national economies of raw materials exporting countries and the national economy of Russia. For data aggregation and reduction to a single format, an information-logical model for formation of the research information base was developed. The obtained scenario model for the development of the Russian financial market forex sector has a high predictive capability. The paper concludes that, based on the scenario model, the forex sector of the Russian financial market will be fairly stable over the next three years, which should be taken into account by the Bank of Russia when making decisions on the forex policy and creation of international currency reserves.
New Currencies in the International Financial Architecture: A Hypothesis of the BRICS Currency Unit
Authors: Zharikov M. V.
Published: December 2018

The subjects of the research are the transformation of the international financial architecture resulting from the internationalization of some currencies of the BRICS countries, mainly the yuan; the position of the BRICS currencies in the world monetary system; and a possibility of creating a common payment unit in the context of collective currencies, cryptocurrencies and similar monetary and financial products. Based on the correlation analysis of the dynamics of the BRICS currency quotations, the paper expresses a hypothesis about a possibility of concluding a monetary union and creating a common BRICS currency. The purpose of the research was to develop the principles of creating a common payment unit for the BRICS countries both for mediation of international economic relations and for wider international circulation. Based on the methods of analogy, comparative analysis, plotting and statistical forecasting, it is proved that the BRICS currency cannot be built on the cryptocurrency principles. It is stated that emission of the BRICS currency as a cryptocurrency will lead to the anarchy of currencies, which will naturally create conditions for the destruction of the monetary union, elimination of the new currency and preservation of the dollar dominance in the global monetary system. The novelty of the research findings lies in obtaining a formula for calculating the amount of the new BRICS currency needed for international circulation. The theoretical significance of the research is the development of a methodology for establishing the exchange rate of the collective currency for the BRICS countries. The practical importance of the research findings is manifested by determining a potentially new BRICS exchange rate in relation to the currencies of the leading countries, plotting the BRICS currency exchange rate trends to predict the limits of currency fluctuations in accordance with the scenarios from the most optimistic to the most pessimistic.
Development of the Long-Term Investment Market: Modern Transformations in the National Mechanism for Economic Growth Financing
Authors: Yakovlev I. A. , Kabir L. S.
Published: December 2018

The economic growth and its sustainability depend on volumes and dynamics of long-term investments that require careful forecast of the future. Therefore, the paper analyzes the development of long-term investment financing in Russia in 2016–2018. The relevance of the research stems from the need to seek new and develop existing sources of funding the economic growth in Russia. The subject of the research is a set of measures implemented in the framework of the national financial market development plan, compared with recommendations of global level institutional investors related to long-term investment financing. The purpose of the research was to formulate proposals on how to introduce global management recommendations into the national financial regulation practice and offer a set of actions to national governments to support long-term investment by institutional investors. Based on the research findings, it is concluded that the priority in the Russian financial policy should be given to decisions towards overcoming national development problems rather than to decisions aimed at harmonization of relations in the investment sphere and creation of favorable conditions for foreign institutional investors. It has been stated that the main criterion for making a financial decision in the Russian Federation should be development level achieved, challenges facing society as well as available resources and opportunities, including the tolerance (or intolerance) level of the international environment. This position is currently demonstrated by the national financial regulator.
Quality Assessment of Financial Management of Budget Investment in Russia
Authors: Alandarov R. A.
Published: December 2018

The subject of the research is the assessment of the quality of financial management of budget investment in Russia. The purpose of the research was to analyze the current legal framework for assessing the quality of financial management of budget investment expenditures and make proposals concerning its development. Based on the comparative analysis of the key methodologies for assessing the quality of financial management of budget investment, it has been concluded that it is necessary to clarify the conceptual framework, expand the system of indicators for assessing the quality of financial management of budget expenditures, including budgetary investment, restructuring the system of indicators for assessing the quality of financial management of budget investment, improving the regulatory framework for assessing the quality of financial budget investment management in Russia. The relevance of the paper, as compared with other publications on this subject, stems from the need to take account of the specifics of capital budget investment in the procedure for assessing the quality of financial management of budget investment. The specifics involve a significant amount of budget investment, a long-term nature of investment projects, their high cost, and lack of ongoing results. At the same time, budget investment can have a potential multiplier effect on the volume of the country’s GDP and GRP in the future. Nowadays, the methodology for assessing the quality of financial management of budget expenditures is unified and does not take into account the indicated specified features of budget investment. Incomplete accounting of the budget investment specifics makes it difficult to establish their effectiveness, which in turn reduces the priority of this type of budget expenditures.
Government Stimulation of the Investment Demand in the Russian Oil and Gas Industry
Authors: Masterov A. I.
Published: December 2018

The subject of the research is the state of the investment activity and investment demand in the Russian oil and gas complex taking into account negative factors that affect further development of the oil and gas industry. The purpose of the research was to expose the reasons for the low investment activity and the short investment demand in the Russian oil and gas complex threatening its further development, given the high equipment depreciation and the lack of modern technologies. The study revealed key negative factors hindering the development of the oil and gas complex and affecting the investment activity and investment demand, and showed the impact of the industry-specific features on the current situation. The need in the coordinated state policy aiming to improve the efficiency of subsoil use as well as to boost the investment activity and investment demand in the oil and gas complex is substantiated. Proposals on the state investment policy, taking into account the successful foreign experience in boosting the oil recovery effectiveness and the rational use of mineral resources, are made. It is concluded that the oil and gas complex requires modernization of the physical infrastructure of enterprises engaged in the oil and gas industry and using advanced methods of enhancing the oil recovery. But the successful solution of the above problems without government participation is hindered by high investment risks associated with the specifics of the oil and gas industry. Under these conditions, the state economic policy that encourages investment in modern methods of enhanced oil recovery and upgrading the production capacities of oil and gas enterprises is becoming increasingly important.
THEORETICAL AND METHODOLOGICAL FOUNDATIONS OF FACILITATIVE ABILITIES DEVELOPMENT OF THE FUTURE PSYCHOLOGIST IN THE CONTEXT OF HIGHER EDUCATION
Authors: Adamska Z.
Published: December 2018

The article is devoted to the illustration of the theoretical and methodological foundations of development facilitative abilities of the future psychologists. It is founded the topicality of the future psychologists’ training, oriented on the basic ideas of humanistic paradigm, the necessity to organize favorable conditions for the development of his abilities.

On the base of the realized theoretical analysis was made an attempt to define the concept facilitative abilities of the future psychologist as integrated combination of emotional, cognitive, behavioral and volitional formations which is revealed in the ability to provide its own efficient functioning, formation and development, and promote the full development of another person.

It is generalized that most researchers refer to facilitative abilities the ability to be yourself (genuineness, sincerity and congruence); ability of self-esteem and self-understanding, respect and understanding of others; the ability to help and support the approval, adoption; trust, sympathetic understanding; the ability to organize conditions for personal development; the ability to organize a special microclimate in the group.

It is determined that the development of the facilitative abilities of the future psychologists is impossible outside of the facilitative environment, in which the self-designing, professional and personal student’s formation directly related to self-development and self-improvement of the teacher-facilitator. One of the most important conditions that provide the facilitation of the environment is subject-subjective (dialogic) interpersonal relationship between teacher-facilitator and student.

Prospects for further research we see in foundation theoretical model of future psychologist’s facilitative activity and developing procedural and methodological apparatus psychological monitoring its development.
PERSONALITY MODEL OF INTELLECTUALY GIFTED HIGH SCHOOL STUDENT
Authors: Vinnyk N.
Published: December 2018

The theoretical model of intellectually gifted high school student’s personality is offered in the article. The components of this model has been substantiated.

Theoretical model includes a personal maturity and intellectual achievements. Personal maturity is based on a structure of personality and has such components as: communicative, motivational, characterological, reflexive, experiential, emotional intellect, psychophysical, which are from their side are based on main individually-psychological qualities of the personality of intellectually gifted high school student.

Psychological features of older teens are determined. On authors opinion, the sensitive period for personal development is an older teen age (15-17 years), when happens that the teen personality transforms into adult personality.

Adult personality is based on communicative motivation, success reaching motivation, reflection, skills of emotions understanding and controlling, intellect, experience for moral self-control and social cooperation’s.
EVALUATION OF EFFECTIVENESS OF PUBLIC PARTICIPATION PROCESSES
Authors: Variagina A.
Published: December 2018

The article talks about the tendency of growth of public participation cases in the current social and political conditions of the country's development. The author compares existing approaches to assessing the effectiveness of public participation processes and highlights that the current assessment methodologies focuses only on researches processes, that related to interaction with the state structures and organizations (vertical vector of public participation forms); practically has no methods that are adapted to analyze the effectiveness of horizontal vector of public participation forms; methods that studies the online public participation process are completely absent. The author pays particular attention to the urgent need to find new methods for assessing the success of public participation in the context of a broader understanding of this phenomenon (vertical and horizontal vectors of public participation), taking into account the newest forms of public participation that are implemented using Internet technologies. The author proposes to create a new tool for studying the effectiveness of public participation process on the basis of one of the existing methods. This new tool provides fourteen indicators and thirty two evaluation criteria, that include such categories as: Process Accessibility, Media Participation, Diversity of Views Represented, Influence on Process, Opportunities for Participation, Integration of users' Concerns, Information Exchange, Project Efficiency, Project Acceptability, Mutual Learning, Mutual Respect, Cost Avoidance, Indirect Cost of Time, Indirect Opportunity Costs, Indirect Costs Associated with Authority and Influence, Indirect Costs Associated with Emotional Issues etc.
Degradation profile of synthetic coral scaffold in cell culture media
Authors: Mahanani Erlina Sih , Lestari Dwi Rizki
Published: December 2018

The scaffold is one of the factors in tissue engineering that determine the success of bone regeneration. The important characteristic of the scaffold is able to degrade gradually. In vitro study using cells, the scaffold will be exposed to culture media. Therefore, degradation profile for scaffold needs to be examined. This study aims to investigate the degradation profile of synthetic coral scaffold in cell culture media using pH measurement. The method used the synthetic coral scaffolds were prepared from denaturalized collagen (gelatin) and calcium carbonate (calcite) with a concentration of 5:5 and 4:6 weight % in aqua dest. The scaffolds were fabricated in membrane thick film which was then physically crosslinked.  The 10 % of gelatin scaffold was used as a control.  The scaffolds were incubated in cell culture media (non-phenol red Dulbecco’s Modified Eagle Medium) for 1 until 8 days, and pH changes of the medium were measured. As the result, Profile of degradation on day 1 to day 4 showed the 5:5 scaffold had the smallest degradation. The results indicated the significant different between scaffold concentration in day 1 (p=0.005), 5th(p=0.03), and 6th day (p=0.011). At the end of incubated days, the pH changed but not significantly different. LSD showed the significant differences between scaffold (5:5 and 4:6) with control and no significant difference between 2 concentrations of the scaffold. The conclusion of this study is the synthetic coral scaffold degraded gradually until the end incubation time and between concentration had different degradation profile in the early incubation time using pH measurement.
On the nature of Russian statehood
Authors: Пахомов Виталий , Pakhomov Vitaliy , Негру Кристина , Negro Kristina
Published: December 2018

The content of the article is devoted to the study of the features of such property of the state as statehood, the specifics of its manifestation on the example of the Russian Federation. The authors come to the conclusion that the Russian state has some formal features of the monarchical form of government, while the legal consolidation of the Republican character. This dualism stems from a complex history of formation and malformatio domestic state and determines the specificity of the state as its basic properties.
No Círio de Nazaré, as filhas da Chiquita também fazem a festa: resistência, conflitos e reinvenção de uma urbe amazônica
Authors: Fernandes Phillippe Sendas de Paula , Seixas Netília Silva dos Anjos
Published: December 2018

Realizado desde 1793, em Belém, Pará, o Círio de Nazaré é uma das maiores festas religiosas do mundo. Nos anos 1970, os frequentadores do Bar do Parque, ícone da boêmia paraense, inspiraram-se no movimento que lutava pelos direitos dos homossexuais nos anos 60, e criaram o que hoje é conhecida como a Festa da Chiquita, elemento profano mais polêmico do Círio. Voltada para o público LGBT, a festa já passou por vários conflitos e sofre com a tentativa constante de desvinculá-la do evento religioso. Buscamos refletir sobre a relação dessa manifestação cultural com a cidade de Belém, levando em conta sua capacidade de transformá-la e produzir novas experiências sensíveis. Nossa estrutura teórica baseia-se em Maffesoli (2009), com a noção da vida cotidiana como obra de arte e sua capacidade de agregação; La Rocca (2015), sobre a construção de uma poética capaz de (re)desenhar os ambientes urbanos; e a ideia de Harvey (2014) sobre o direito à cidade principalmente para as pessoas oprimidas.
A solidão das meninas negras: apagamento do racismo e negação de experiências nas representações de animações infantis
Authors: Gomes Barbosa Karina , De Souza Francielle
Published: December 2018

Este artigo analisa representações, imagens e afetos da infância feminina negra na mídia. Para isso, foram mapeadas e investigadas seis meninas negras protagonistas de desenhos animados exibidos pela TV a cabo no Brasil. Com a perspectiva culturalista e o aporte teórico dos estudos feministas e de raça, verificamos por meio de análise fílmica como as animações lidam com o imbricamento entre raça, gênero e infância, produzindo efeitos de solidão e silenciamento. Além disso, este trabalho busca questionar a ideia de menina negra, os recentes discursos em torno do empoderamento das meninas para o desenvolvimento global e os afetos acionados pelos produtos midiáticos em análise, colocando-os em diálogo e em tensão com a realidade vivida por meninas negras brasileiras, duramente atravessada pelas desigualdades de gênero, raça e classe.
Fragilidade branca
Authors: DiAngelo Robin
Published: December 2018

Os brancos da América do Norte vivem em um ambiente social que os protege e isola do estresse relacionado às questões raciais. Este ambiente isolado de proteção racial cria expectativas brancas de conforto racial ao mesmo tempo em que diminui a capacidade de lidar com o estresse racial, levando ao que eu chamo de “Fragilidade Branca”. A Fragilidade Branca é um estado em que até mesmo uma quantidade mínima de estresse racial se torna intolerável, desencadeando uma série de movimentos defensivos. Esses movimentos incluem a expressão de emoções como raiva, medo e culpa, e comportamentos como discussão, silêncio e abandono da situação criadora de estresse. Esses comportamentos, por sua vez, funcionam para restabelecer o equilíbrio racial branco. Este artigo explica a dinâmica da Fragilidade Branca.
Racismo
Authors: Sovik Liv
Published: December 2018

Editorial - Dossiê - Racismo - ECO-Pós v21 n32018