bluuebunny/crossref_metadata_2025 huggingface dataset:
BMAL1 regulates osteoblast differentiation through mTOR/GSK3β/β-catenin pathway
Authors: Li Huixia , Meng Hui , Xu Min , Gao Xin , Sun Xulei , Jin Xinxin , Sun Hongzhi
Published: March 2023

Bone mass declines with age and its maintenance is tightly linked to osteoblasts (crucial bone-building cells). Although disruption of the peripheral circadian clock is involved in various pathologies including aging-related diseases, evidence regarding how the peripheral clock regulates bone mass remains elusive. In the present study, we aimed to elucidate the effects of Bmal1 (the key activator of the peripheral circadian clock system) knockdown by lentivirus-mediated shRNA on osteoblast differentiation and its related mechanisms. We found that the expression of osteogenic markers, alkaline phosphatase activity, and mineralization were decreased, whereas apoptosis and inflammatory response were increased in Bmal1 knockdown osteoblasts. In addition, Bmal1 knockdown promoted ERK and JNK phosphorylation, as well as mTOR activity, whereas mTOR inhibition by rapamycin abrogated Bmal1 knockdown-mediated effects on osteoblast differentiation and mineralization capacity. Remarkably, Bmal1 knockdown in osteoblasts inhibited GSK3β/β-catenin signaling with decreased β-catenin expression and GSK-3β phosphorylation at serine 9, while GSK3β inhibition with TDZD-8, but not WNT3a or SKL2001, rescued Bmal1 knockdown-induced defects in osteoblast differentiation. Moreover, rapamycin partly nullified the suppression of Bmal1 knockdown on β-catenin expression and GSK-3β phosphorylation. Collectively, overall data indicated that circadian gene Bmal1 regulated osteoblast differentiation and inflammatory response in an mTOR/GSK3β/β-catenin-dependent manner, and thereby may contribute to the mineralization process and bone modeling/remodeling.
Paradigm shift in frog sperm cryopreservation: reduced role for non-penetrating cryoprotectants
Authors: Upton Rose , Clulow Simon , Colyvas Kim , Mahony Michael , Clulow John
Published: March 2023

In brief

Sperm cryopreservation has been recognised as a tool for preventing loss of genetic diversity in amphibians; however, the combined effect of penetrative and non-penetrative cryoprotectants in cryodiluents is poorly understood. We demonstrate a clear benefit of using low concentrations of non-penetrative cryoprotectants when cryopreserving sperm of Australian tree frogs.

Sperm cryopreservation protocols have been developed for an increasing number of amphibian species since the recognition of a global amphibian decline. Yet, the development of these protocols has neglected to elucidate the combined effect of the penetrative(PCP) and non-penetrative cryoprotectant (NPCP) on the recovery of live, motile sperm. The two-factor hypothesis of cryoinjury recognises a trade-off between cooling cells slowly enough to allow osmotic dehydration and therefore avoid intracellular ice formation, but fast enough to minimise effects from increasing extracellular osmolality as the frozen fraction of the media increases during freezing. We tested the effect of two concentrations of a PCP (10 and 15% v/v dimethyl sulfoxide (Me2SO)) and two concentrations of an NPCP (1 and 10% w/v sucrose) in various combinations on the sperm of six pelodryadid frogs. In all species, 15% v/v Me2SO with 1% w/v sucrose provided superior post-thaw recovery with high proportions of forward progressive motility, live cells and intact acrosomes (typically >50% for each). Theoretically, it has been suggested that increased NPCP concentration should improve cell survival by increasing the rate and extent of cell dehydration. We suggest, however, that the elevated osmolality in the unfrozen water fraction when 10% sucrose is used may be causing damage to cells via excessive cell shrinkage and solute effects as proposed in the two-factor hypothesis of cryoinjury. We showed this response in sperm across a range of frog species, providing compelling evidence for this hypothesis. We suggest protocol development using the PCP/NPCP ratios demonstrated in our study will be broadly applicable to many amphibian species.
Fish consumption at the ancient market of Monterrey (18th-19th centuries), México, based on archaeological remains
Authors: Guzmán Ana Fabiola , Espino Miriam , Rivera Estrada Araceli
Published: March 2023

Durante los trabajos de remozamiento del actual Museo Metropolitano de Monterrey, se rescataron diversos restos de fauna del antiguo mercado de la ciudad de Monterrey, entre ellos material de peces. Poco se sabe del antiguo consumo de peces en el noreste de México y estos materiales brindan la oportunidad de explorar ese aspecto. Se analizó un total de 1204 restos de peces, de los cuales el 27% fue identificado y representa a 8 taxa de peces dulceacuícolas (bagres y mojarras) y marinos/estuarinos (robalos, jureles, pargos y corvinas). Predominan los materiales de origen marino, particularmente de las corvinas (Sciaenops ocellata: 65 % de los restos identificados y el 35 % de los individuos). La tercera parte de las especies y de los individuos son bagres dulceacuícolas. Monterrey está ubicado en la cuenca del Río Bravo, a 300 km de distancia del Golfo de México, por lo que la presencia de ambos componentes pesqueros indica la existencia tanto de un comercio semilocal (ríos) como de uno a distancia (costera). La representatividad de las regiones corporales sugiere que los peces dulceacuícolas se transportaban completos, y posiblemente sea el mismo caso en los peces marinos.
A Post-cranial Osteometrical Database for the Spanish ibex (Capra pyrenaica Schinz, 1838)
Authors: Llorente Rodríguez Laura , Quiralte Victoria
Published: March 2023

En Zooarqueología la evaluación del tamaño corporal, tanto para inferir cambios de talla espacio-temporales como para estimar la proporción de sexos, requiere de bases de datos que abarquen la variabilidad documentada para dicha especie. Siendo la cabra montés un recurso clave en la Península Ibérica desde el Paleolítico Superior, sorprende la falta de bases de datos osteométricos. Este trabajo pretende neutralizar tal ausencia para el caso del esqueleto postcraneal incorporando medidas de las dos subespecies existentes, así como una recopilación de medidas de yacimientos vascos del Pleistoceno Superior y las de la colección recuperada en el Sector C del abrigo levantino de Cova Fosca.
Carboxyl cellulose nanocrystal extracted from hybrid poplar residue
Authors: Wu Yu , Cao Fei , Jiang Hua , Zhang Yang
Published: March 2023

Ammonium persulfate (APS) oxidation was employed to isolate carboxyl cellulose nanocrystals (CNCs) from hybrid poplar residue. Structure changes resulting from APS oxidation were investigated by Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD). The further oxidation of the ensuring CNCs with sodium periodate manifested selective oxidation of hydroxyl groups at the C6 position of cellulose into carboxyl groups during APS oxidation. The introduction of active carboxyl groups resulted in lower thermal stability. Transmission electron microscopy (TEM) and width distribution showed that the produced CNCs ranged from 10 nm to 24 nm. Carboxyl CNCs with a yield of 63.2% were isolated via APS oxidation, and they were suitable for large-scale CNCs production.
Composite process and electrothermal properties of a new-type electric heating plywood made with melamine resin adhesive film
Authors: Yang Sheng , Su Chuwang , Song Leiluo , Yuan Quanping
Published: March 2023

A new type of electric heating plywood used for indoor heating products was made using melamine resin adhesive film (MRAF) as the bonding material and carbon fiber paper (CFP) as the electric heating material. Hot-press pressure greatly affected the permeation of the adhesive into the CFP and bonding performance, resulting in a bonding strength above 1.8 MPa. The conducting path in the electric heating layer was the main factor affecting the drop rate of resistance (DRR). Pressure of around 1.3 MPa was beneficial in controlling power deviation. Use of the MRAF improved insulation and water resistance. The plywood exhibited a surface temperature difference of 6 °C under commonly used power. Temperature rise exhibited an exponential relationship with heating time, and surface equilibrium temperature had a linear relationship with power density. The plywood had good power stability because the maximum resistance changed by only 0.44% when electricity was overloaded for 24 h at a power density of 500 W/m2. Stable resistance was presented after power was cycled 40 times, and the maximum DRR was 1.25% after 120 power cycles. This scheme offers a simple process for large-scale manufacture of the adopted MRAF, which has good bonding performance and electric heating stability.
The effect of chemical treatment on green color preservation and surface characteristics of Neosinocalamus affinis bamboo
Authors: Chen Lin , He Lu , Xie Jiulong , Qiu Zhongpeng , Jiang Yongze , Xiao Hui , Chen Yuzhu , de Hoop Cornelis F. , Hse Chung-Yun
Published: March 2023

Bamboo culms or bamboo plywood possessing a native green surface color are highly valuable for use in interior decoration. However, the green surface color of bamboo can easily become discolored in ambient environments without any protection. In order to maintain the green surface color of Neosinocalamus affinis bamboo, this study used copper sulfate (CuSO4), phosphoric acid (H3PO4), and acetic acid (CH3COOH) solutions as protectors. The changes in surface color and characteristics of the bamboo samples before and after the treatment were evaluated. The results showed that the N. affinis bamboo samples treated with 2% CuSO4 solution at 80 °C for 3 h exhibited an attractive green color, with a* and b* values of -7.61 and 5.13, respectively. The indoor durability test result indicated that bamboo samples treated with CuSO4, CuSO4/H3PO4, and CuSO4/CH3COOH solutions all had excellent color durability. After the treatment, the relative copper content on the bamboo surface slightly increased, while the magnesium content decreased. The chlorophyll structure was changed, and reactions between chlorophyll and copper ions may have occurred. The silicon was almost completely removed, and the surface structure of the treated bamboo changed, resulting in good permeability for the treatment.
Utilization of agrowaste-derived nanoparticles as reinforcement in microfilled epoxy composites
Authors: Rizal Samsul , Fizree H. M. , Owolabi F. A. T. , Gopakumar Deepu A. , Paridah M. T. , Kassim Mohamad Haafiz Mohamad , Fazita M. R. M. , Syakir Muhammad Izzuddin , Khalil H. P. S. Abdul
Published: March 2023

The substantial release of oil palm ash into ground water has been a serious concern to the environmentalist due to the enormous generation of oil palm ash waste from oil palm incineration. The effective utilization of this agrowaste is yet to be fully exploited. In this context, herein we, investigated the potential of oil palm ash nanofiller as an effective reinforcement in epoxy-based composites. Transmission electron microscopy (TEM) revealed that the prepared oil palm ash nanoparticles had circular morphology with particle size in the range of 20 to 25 nm. X-ray diffraction patterns of the prepared oil palm ash nanoparticles revealed the crystalline nature of the oil palm ash nanoparticles. Tensile strength and tensile modulus of the epoxy composites were substantially improved to 64, 67, 70, and 75 MPa and 1.01, 1.05, 1.16, and 1.18 MPa at oil palm ash nanofiller loading of 1%, 2%, 3%, and 4%, respectively. The impact strength of nanocomposite was enhanced from 2.7015 ± 0.13 kJ/m2 to 3.98 ± 0.17kJ/m2 at 3% of oil palm ash nanofiller loading. The optimum values of mechanical properties were attained at 4% filler loading, after which further loading resulted in the decrement of mechanical properties of epoxy nanocomposite. Thermal stability of the epoxy nanocomposite was enhanced substantially to 435 °C by the incorporation of oil palm ash nanofillers. This study proved that nano-sized oil palm ash could be an efficient reinforcement in polymer composite.
Comparison of structural characteristics of straw lignins by alkaline and enzymatic hydrolysis
Authors: Jin Di , Dong Weifang , Zhang Haitao , Ci Yuhui , Hou Lipeng , Zang Lihua , Kong Fangong , Lucia Lucian
Published: March 2023

Lignin was separated from wheat straw by NaOH cooking and enzymatic hydrolysis, obtaining yields of 86.2% and 78.6%, respectively. Fourier transform infrared spectrometry (FT-IR) and two-dimensional nuclear magnetic resonance (2D-HSQC) analyses indicated that the H units (p-hydroxyphenyl units) of the Enzymatic Hydrolysis Lignin (EHL) did not suffer much damage. The number-average molecular weight (Mn) of the EHL measured by gel permeation chromatography (GPC) was 3348 g/mol, which was higher than that (3047 g/mol) of Alkali Lignin (AL). The Cr(VI) adsorption experiments demonstrated that the maximum removal percentages and maximum adsorption amount of the EHL and AL were 31.5%, 88.9%, 135.1 mg/g, and 271.7 mg/g, respectively. In addition, the adsorption kinetics, adsorption isotherm and thermodynamics of Cr(VI) on these two lignins were reported in detail.
Effects of pressure and temperature on wood impregnation – Focusing on larch (Larix kaempferi) and Korean pine (Pinus koraiensis)
Authors: Jang Eun-Suk , Kang Chun-Won
Published: March 2023

The primary purpose of this study was to delineate the most significant factors in the wood impregnation process. For this, the authors prepared larch (Larix kaempferi) and Korean pine (Pinus koraiensis) wood and used alkaline copper quaternary as an impregnation solution. The chamber temperature was adjusted to 25, 50, and 80 °C, and the pressure was adjusted to 100, 200, and 300 psi. The impregnation process was maintained for up to 90 min. Multiple regression analysis was used to investigate the effects of temperature, time, and pressure in terms of amount of solution impregnated during the process. Factors affecting the amount of solution impregnated were as follows: the effect of pressure was greater than that of time, which was greater than that of temperature. Therefore, pressure was the most critical factor in the wood impregnation process.
Utilización del nemátodo Caenorhabditis elegans en ensayos de toxicidad en muestras de agua del río Calera, Ecuador
Authors: Pilaloa-Tamayo Juan , Gonz´ález-Carrasco Víctor , Florencia-Kronberg María , Valverde-Durán Sergio
Published: March 2023

The province of El Oro is the most important gold mining area in Ecuador, but the activity has caused damage to the ecosystem and human health, due to the dumping of extraction waste loaded with heavy metals into the Calera River, which is a tributary with the Yellow River of the Puyango river. This work presents the results of the evaluation of the toxicity of the water and sediments of the Calera River using the nematode Caenorhabditis elegans as a bioindicator for environmental monitoring. The quantification of heavy metals by atomic absorption spectroscopy in samples collected along the Calera River, both in water and in sediments, revealed that the concentration in water was below the permissible limits established by the Ecuadorian Environmental Standard, while in the sediment sample, the concentration values of heavy metals considerably exceeded the permissible limits, particularly Arsenic and Cadmium, which were the ones detected with the highest concentrations. In the bioassays with C. elegans subjected to different concentrations and exposure times of 12, 18, 24 and 36 hours, no mortality rate was detected in the water samples analyzed, which is attributed to the low concentration of heavy metals. The exposure of the nematodes to the sediment extracts, induced mortality in all the samples, mainly in those coming from the sector in which the rock material processing plants are located.
The influence of loads of various magnitudes and directions on the visual acuity of high-qualified visually impaired sprinters
Authors: Adzhametova Leilia , Shesterova Liudmyla
Published: March 2023

Purpose: determine the impact of loads of different magnitudes and directions on the visual acuity of a highly qualified female athlete with visual impairments, specializing in sprinting.

Material & methods. The study was conducted in the general preparatory period of the annual training cycle with the participation of the Honored Master of Sports of Ukraine in athletics among athletes with visual impairments. The following research methods were used: analysis of documentary materials (diaries and preparation plans of the studied athlete), pedagogical observation; Pedagogical experiment (author's experiment), visometry, methods of mathematical statistics.

Results. It has been established that an increase in the load has a negative effect on visual acuity. The results obtained in the course of the study indicate a general trend in the response of both eyes to a load of a different nature.

Conclusions. The use in the preparatory period of loads of a strength orientation, complex for endurance, coordination and flexibility, leads to an increase in visual acuity, which in turn has a positive effect on the functional state of the visual analyzer. Large loads aimed at speed endurance and having a speed-strength character lead to a decrease in visual acuity and, as a result, negatively affect the functional state of the visual analyzer.
A comparison of continuous positive airway pressure initiation techniques in the treatment of obstructive sleep apnoea/hypopnoea syndrome in adults
Authors: Stanley Renna Maxwell
Published: March 2023

Introduction: This project assesses the differences between CPAP usage, a year after initiation, when patients were introduced to therapy via inpatient respiratory studies, outpatient auto-titration studies or a combination of the two. Methods: The retrospective review of 98 CPAP patients’ usage data was collected and statistically analysed using ANOVA tests, Chi-squared and Kruskal Wallace testing. Results: The findings showed a small clinically significant difference but no statistically significant differences in usage across the three groups (p>0.05). Combining initiation techniques improved yearly CPAP usage by up to 365 hours. The difference between RESP and APAP average usage was 90 hours a year. No statistically significant difference in usage between the three groups was seen. The APAP pathway is the most cost-effective and significantly reduces the time taken to get on to CPAP treatment. Demographic variables are not found to predict nightly usage. All patients increased in weight over the year. Conclusion: The results demonstrate higher levels of usage when combining initiation techniques, indicating initiation with high levels of interaction with healthcare professionals is beneficial. Significant weight gain across all groups poses the moral question of whether CPAP should be issued prior to initial weight loss attempts.
Level of uncertainty in people living with HIV
Authors: Saucedo Pahua Gerardo , Huerta Baltazar Mayra Itzel , Alcántar Zavala Ma. Lilia , Ruiz Recéndiz Ma de Jesús , Jiménez Arroyo Vanesa , Andrade Herrera Rafaela
Published: March 2023

Introduction: Worldwide, human immunodeficiency virus (HIV) infection continues to be an emerging public health problem. With the positive screening of this chronic degenerative disease, the virus generates physical, psychological, social and spiritual changes in people, that lead to uncertainty in the face of an uncertain future. Identifying the uncertainty in the patients, allows the care professional to plan integral interventions to favour the reduction of this process and can integrate well-being in the experience with their chronic condition and thus, have quality of life. Objective: To determine the level of uncertainty in a group of people living with HIV. Method: Quantitative, descriptive and transversal study. Non-probabilistic sampling of 30 people living with HIV, from the CONVIHVE Civil Association of Morelia, Michoacán. An identification card and the scale “Uncertainty in front of the disease” (MUIS) of Merle Mishel were applied, with a reliability of (.904). The statistical package SPSS V was used to analyze the data. 22. Results: 83.3% of the total population are men and 16.7% are women, 32-39 years of age (36.6%) of whom 70% are men. Being single, 53.3% have a bachelor’s degree. 60% report being employed. 30% of the population refers to having more than 10 years of diagnosis and less than 5 years in treatment 53.3%. 76.7% are Catholic. From the total of participants, 23.3% showed a low level of uncertainty, followed by a level of regular uncertainty with 26.7%, and 50% showed a high level of uncertainty. Conclusion: The level of uncertainty in people living with HIV is high. It is necessary to carry out comprehensive interventions that favour the reduction of the level of uncertainty and thus improve the well-being and quality of life of people living with HIV.
Public health equity in information asymmetry – phenomenological studies upon SARS-CoV-2 supervirus mutation
Authors: I Pachankis Yang
Published: March 2023

In the context of SARS-CoV-2 crises, the phenomenological studies analyze the market phenomenon of People’s Republic of China (PRC) in public health. With PRC’s diplomatic behaviors around the national, international, and global public health crises, the phenomenological occurrence was further questioned into on accounts of genetic engineering, PRC’s top-down behaviors, and financial and non-financial incentives in public health inequality with its declared universal healthcare coverage. The phenomenological studies further the evidence chains on the PRC governmental bodies’ purposeful and intentional crimes against humanity, with the public health system they designed to hide criminal evidences in the clinical evidence chains. Albeit it is paramount for the medical professionals to prepare for a certain but unforeseeable surge of biomedical intrusion, the phenomenological studies call for military interventions on the humanitarian catastrophe that have twice in three years caused unnecessary sufferings regionally and globally. Without it, the world can only wait to detect Chinese passengers’ carriers instead of obtaining firsthand data, potentially leading to more deaths and mutation risks. Only peace-building and government reformation on democratic basis in the region can solve the humanitarian crisis once and for all. No scientific evidence establish the virological homogeneity between SARS-CoV and MERS-CoV, and the politicization of the HIV-1 homogeneous virus underlies the 2002 - 2003 outbreak that caught international attention. The long-term PRC derogation on the global institutional determinants of health has led to the global mandates of poisoning by “vaccination”. The viral RNA origin is inferred to mutational result of PRC’s nuclear weapon tests.
A case of post-stroke pain and gait improved by spinal cord stimulation therapy
Authors: Maeda Hiroyuki
Published: March 2023

A female patient had residual numbness and pain in the right half of the body after intracerebral hemorrhage (capsular hemorrhage). After a 1-week trial of spinal cord stimulation (SCS), the Numerical Rating Scale (NRS) improved from 10 to 5 and the Oswestry Disability Index (ODI) improved from 76 to 52. The patient was able to lift her legs, and her 210-cm walking time improved from 24.79 s to 15.25 s, which was highly satisfactory. One month after the trial, pain flared up and gait worsened; thus, SCS implantation was performed at the request of the patient and her family. Pain and numbness have subsequently decreased and range of motion has increased. One electrode was implanted in C4 and the other electrode was implanted in Th8. This case suggests that SCS therapy may be useful for central post-stroke pain (CPSP) that involves pain and numbness that affect half of the body.
Psychoanalysis and psychiatry: the important role played by differential diagnosis in treatment management processes
Authors: Marquesarques Luciana Ribeiro MLuciana Ribeiro , Assumpcao Bastos Adriana Dias de , Tafuri de Araujo Pedro Antonio Mourão
Published: March 2023

J. Chick Jr.’s case is paradigmatic when it comes to the hard time establishing differential diagnosis. He has been a heavy drinker and drug user since adolescence, and was hospitalized in psychiatric institutions several times, as well as had a vast collection of diagnoses he identified himself to. Based on what he calls his lack of identity, Chick Jr. gives significant importance to diagnoses capable of identifying him and of telling who he is. This lack of identity, which is experienced as non-existence – sometimes he says that he is dead – unfolds into a sexual identity that brings him a lot of suffering. We know that individuals are not defined by their diagnosis, even when it sometimes calms them down. In any case, differential diagnosis is extremely important to help mental health professionals manage patients’ treatment; it is what the current study aims at showing, based on the herein reported case
Sero-prevalence of hepatitis-c virus among blood donors in northern Pakistan
Authors: Ali Shoukat , Ali Basit , Khan Bakht B , Khan Manzar , Ali Sohail , Iqbal Asif , Khan Tamreez , Ullah Shafqat , Rahman Mujeeb Ur , Gul Maryam
Published: March 2023

HCV is a hepatotropic single strained positive sense RNA virus belongs to family Flaviviridae. HCV is worldwide distributed virus affects about 185 million peoples as a result it causes 500,000 deaths per year. In Pakistan 5-6% of individuals are infected with HCV while in blood donors this ratio varies from 1.05-3.24 in different region of Pakistan. In Peshawar sero-prevalence of HCV was 4 percent. This study focuses on the actual status of HCV among blood donors at district Mardan and to compare the findings with previous study and shows the differences. The data were collected in MMC-MTI Mardan from January 2019 to May 2019. Through CMIA (by architect 1000i) methods the quantitative detection of anti-HCV antibodies takes place and 625 samples diagnosed through EIA methods, in which 9 were positive to HCV antibodies. Overall sero-prevalence of HCV positive donors is 1.44% and high prevalence were founded in the male which was (1.45%), rural area (1.95%), illiterate donors (2.08%), married donors (2.20%), donors belong to lower class economic status (2.21%), 1st time donors (1.72%) and age group 38-47 (3.64%) were positive to HCV. The risk factors of HCV transmission are IVD use, unscreened blood transfusion, contaminated surgical instruments and shaving in barber shop. The findings of this study show that the sero-prevalence of HCV increased 0.24% from 2018 among blood donors at district Mardan. It was recommended that more studies required to explore the seroprevalance of HCV in other cities of Pakistan.
Barbiturate coma treatment in children with refractory intracranial hypertension due to traumatic brain injury; is it useful?
Authors: Tirado Pérez Irina Suley , Zárate Vergara Andrea Carolina
Published: March 2023

In pediatric severe Traumatic Brain Injury (TBI) the appearance of refractory intracranial hypertension is related to an unfavourable prognosis. Severe TBI (ECG <8) is present in 60% of polytrauma children and is associated with high morbidity and mortality. The monitoring of intracranial pressure (ICP) and the treatment of intracranial hypertension have been subjects of attention in neurotrauma for years in the evidence-based guidelines currently being a topic of discussion. Currently the guides based on evidenceshowing acceptance of some guidelines for the management of intracranial hypertension, within the most accepted of sedatives/analgesics, hyperosmolar agents (hypertonic saline solution HTS and mannitol) and barbiturates, although the level of evidence of these recommendations is insufficient to standardize such management in the centers of attention.
"Outcome evaluation of physiotherapy & drug management for chronic cervical radiculopathy"
Authors: Ehsan Siddique Mustafa Amimul , Rahman M Mazibar , Islam Md Shofiqul , Islam Md Waliul
Published: March 2023

Background: Cervical radiculopathy (CR) is one of the prevalent causes of neck pain and disability. Physiotherapy and pain medications are the common nonoperative management, and in Physiotherapy, there are many concepts of assessment and management. This study aims to determine the comparative effectiveness of three specialized physiotherapy approaches or only pain medications for managing CR cases. Methods: A prospective, assessor, and participant-blind, four-arm Randomized control trial (RCT) has been conducted on 120 patients with chronic cervical radiculopathy in 4 specialized centers of Dhaka city recruited between July and December 2022. Four groups (n=30) was treated through structural diagnosis and management concept (SDM), regional approaches (RA), McKenzie mechanical diagnosis and therapy (MDT) concept prescribed by advanced practice physiotherapist (APP), or pain medications prescribed by the specialist physician for 4 weeks. Discussion: After 24 sessions every group shows improvement in neck pain, ROM, disability and quality of life. During intermediate analysis (14days), no group shows more significant changes than another. After post changes (24days) the pain severity score differ significantly only between Medication and RA, RA and Medication; mean pain affective interference score differ between Medication and RA, RA and Medication; and pain physical interference between Medication and RA; RA and Medication. Mean score of ROM were significantly different between medication and RA, Medication and SDM; MDT and RA, MDT and SDM; RA and Medication, RA and MDT; SDM and Medication, SDM and MDT. Besides mean score of WHOQOL Brief (physical) were significantly different between Medication and SDM (p=.000); MDT and SDM (p=.000); RA and SDM (p=.045); SDM and Medication (p=.000), SDM and MDT (p=.000), SDM and RA. Overall improvement (mean score changes) found in pain, ROM, disability, QOL among all groups. Trial registered to the Clinical Trial Registry India CTRI/2022/03/040922 on 08/03/2022.
Influence of Suction Hole Diameter of Precision Seed Machine on the Characteristics of Feeding Corn and Sunflower Seeds
Authors: Nesmiyan Andrey Yu. , Dubina Konstantin P. , Zhigailova Anastasiya P.
Published: March 2023

Introduction. The study of working processes of row crop seeders, their improvement, increase in productivity and (or) quality of work are topical agroengineering tasks.
Aim of the Article. The article deals with developing proposals to optimize the design of vacuum mechanisms for row crop seeders based on the analysis of the laws of the process of dosing sunflower and corn seeds by suction holes of the seed discs.
Materials and Methods. The operation characteristics of the vacuum seeding mechanism depend on the diameter of the suction holes and the rarefaction in the vacuum chamber. Hypothetically, it can be assumed that with a constant calculated value of the suction force, it is possible to choose a ratio of these characteristics in which the number of skips and group feeding of seeds will not exceed the tolerance of agro-requirements. Verification of this assumption was carried out experimentally in laboratory conditions.
Results. There were found polynomials describing with a fair degree of accuracy the dependence of formation of group feedings of sunflower and corn seeds on the diameter of suction holes.
Discussion and Conclusion. The frequency of group feeding of the seeds less than 0.05% will be achieved with suction hole diameters of about 0.8 mm for sunflower and about 1.9 mm for corn. In this case, the values of rarefaction in the vacuum chamber must be 31–56 kPa that exceeds the capabilities of the pneumatic systems of existing row seeders. Accordingly, the modernization of the seeding mechanisms of vacuum row seeders by reducing the diameter of the suction holes should be accompanied by additional improvements aimed at increasing their gripping ability.
The Use of Disk-Shaped Diaphragm of Vehicles in Double-Circuit Diaphragm Pumps
Authors: Levtsev Alexey P. , Lapin Evgeniy S. , Chen Daifen
Published: March 2023

Introduction. The article concentrates on improving the efficiency of double-circuit diaphragm pumps, which can be successfully used in heat and water supply systems of industrial and agricultural facilities where there is excess head. It is advisable to equip double-circuit diaphragm pumps with disc-shaped diaphragms interconnected by a rod, for example, from motor vehicles, and to drive them from the available head of the hydraulic network. In order to increase the efficiency of their work and further use, it is necessary to predict the hydraulic characteristics according to the geometric parameters of the membranes and the cycle of their operation in dynamics.
Aim of the Article. The article aims at obtaining adequate calculated dependencies of pumped liquid flow rate on speed of double-circuit diaphragm pumps.
Materials and Methods. There were used the idealization method from differential geometry, physical experiment, and mathematical statistics to solve the tasks for identifying the relationship between the rod motion and the liquid flow rate for a poppet diaphragm with different geometric surfaces in dynamics. There have been obtained the dependences of pumped liquid volume on the movement of the point of attachment by the poppet diaphragm and the volume flow rate on the movement speed of the point of attachment by the poppet diaphragm with specific geometric parameters for the parabolic and chain line. An experimental testing of the dependence of displaced pumped liquid flow rate on the movement of the attachment point to the stem for the diaphragm type 30 was carried out.
Results. Based on the obtained dependences of the volume flow rate on the speed of movement of the point of attachment by a poppet diaphragm with specific geometric parameters for a parabolic and chain line, there were constructed the graphs of dependences of the volume flow rate on the frequency of the working cycle. For practical implementation, there are proposed the dependencies for constructing the hydraulic characteristics of a two-circuit membrane (the dependence of the volume flow rate on the frequency of the working cycle) obtained on the basis of a parabolic interpretation.
Discussion and Conclusion. The hydraulic characteristics of a two-circuit membrane pump are close to the equation of a straight line and are consistent with experimental dependencies within 4%.
Kismarty-Lechner Jenő templomépítészete •
Authors: Hajós-Baku Eszter
Published: March 2023

Kismarty-Lechner Jenő templomtervezői pályája 1916-ban indul – s ha a templomátalakításokat is számba vesszük, akkor az 1950-es évekig hatalmas ívet ír le tevékenysége, mely sok esetben nem választható el oktatói pályájától és műemlékes munkáitól. Templomtervezői munkásságának tetemes része a két világháború közötti időszakra tehető, mely egyben a korszak stíluspluralizmusának kiváló reprezentánsa. Esetében igen széles spektrum rajzolódik ki a pártázatos reneszánsztól kezdve a neoklasszicizmuson át a magyaros és nemzeti tendenciák újraértelmezésén túl a modern templomépítészetig, melyben máig kiemelkedőt alkotott. Kismarty recepciójához hozzátartozik, hogy lényegében a legtöbb szakirodalom az építész gazdag alkotótevékenységére helyezve a hangsúlyt a változatos stílusokban tervezés mellett a magyar szecesszió továbbéléseként, a magyar nemzeti stíluskeresés egyik állomásaként értékeli, kiemelve, hogy az önálló építészeti formanyelv megteremtésének forrásait inspiratív módon a felvidéki / felső-magyarországi pártázatos reneszánszban és a magyar népi építészetben találta meg. Emellett a kutatás során összegyűjtött és a korszak templomépítészetének tükrében értékelt épületei és tervei azt mutatják, hogy Kismarty-Lechner Jenő a modern templomépítészet létrejöttében jelentős szerepet játszott. Jelen kutatás törekszik Kismarty-Lechner Jenő hatalmas templomépítészeti munkásságát folyamatában, a források tükrében bemutatni s a különféle gyűjteményekben megőrzött terveit egymás mellett vizsgálni.
Accelerated dissolution of doped UO2-based model systems as analogues for modern spent nuclear fuel under repository conditions
Authors: Kegler Philip , Neumeier Stefan , Klinkenberg Martina , Bukaemskiy Andrey , Deissmann Guido , Brandt Felix , Bosbach Dirk
Published: March 2023

Systematic single-effect dissolution studies were carried out on the dissolution behaviour of pure and Cr- or Nd-doped UO2 reference pellets as model materials for spent nuclear fuel with varying doping levels, densities, and grain sizes as well as of industrially produced Cr- and Cr/Nd-doped UO2 pellets. The results were obtained from accelerated static batch dissolution experiments performed under strictly controlled conditions using H2O2 as simulant for radiolytic oxidants formed due to the alpha-irradiation of water. The results indicate that the addition of Cr and the consequential modification of the fuel matrix does not lead to a significant change of the dissolution behaviour of these model materials compared to pure UO2 reference materials. Contrarily, the dissolution rates of Nd-doped pellets are significantly lower than those of pure and Cr-doped pellets. These results provide additional insights into the influence of doping on the dissolution behaviour of modern spent light water reactor fuels under the post-closure conditions expected in a deep geological repository.

Graphical abstract
Duszpasterska działalność diecezji sosnowieckiej w latach 1992-2007
Authors: Kempiński Paweł
Published: March 2023

The aim of the work is to show the pastoral activity of Diocese of Sosnowiec during the pastoral ministry of the first Bishop Adam Śmigielski SDB. The concept of pastoral care found its foundation in the teaching of the Second Vatican Council, John Paul II, and the pedagogy of Saint John Bosco, who became an inspiration for the Bishop as a Salesian, as well as in the models of patrons accepted for this local Church. The pastoral care in the diocese was a response to the social and religious problems of the faithful of the Zagłębie Dąbrowskie region. The work presents the development of the diocese with its structures and the first synod against the background of historical, religious and social conditions. The most important pastoral initiatives (care for the clergy, pastoral care of families, youth, working people, charity work), selected pastoral events and examples of Catholic associations, the function of sanctuaries and ecumenical activities were presented. The source of the research were archives of Diocese of Sosnowiec, texts of speeches by Bishop Śmigielski, theological and popular publications of the analysed period, as well as documents of the first Sosnowiec synod. The positions of secular researchers, especially historians and sociologists, were used to outline the socio-religious situation.
Comparing discrete Pareto populations under a fixed effects model
Authors: BARATNİA Mohammad , REZAEİ ROKNABADY Abdolhamid , DOOSTPARAST Mahdi
Published: March 2023

The discrete Pareto distribution can be considered as a lifetime distribution and then is widely used in practice. It follows the power law tails property which makes it as a candidate model for natural phenomena. This paper deals with comparison of discrete Pareto populations by proposing a non-linear fixed effects model. Estimators for the factor effects are derived in explicit expressions. Stochastic properties of the estimators are studied in details. A test for assessing the homogeneity of populations is proposed. Illustrative examples are also given. The proposed model is an alternative model for analyzing data sets in which the linear models have poor performance.
Üniversite Öğrencilerinde Dijital Kimlik Kullanımı ve Benlik Sunumu Üzerine Bir İnceleme
Authors: AKKAŞ İbrahim , AKSAKAL İbrahim
Published: March 2023

Son yıllarda yaygınlaşan çevrimi içi iletişim araçları dijital kimlik kullanma alışkanlıklarını beraberinde getirmiştir. İnsanlar giderek artan sayıda ve çeşitli sebeplerle çevrim içi iletişim araçlarını kullanmakta ve bu iletişim araçları için dijital kimlikler oluşturmaktadır. İnternet kullanıcıları bu araçları eğlence, hizmet alımı, alışveriş, iletişim ve eğitim gibi birçok amaç için kullanmaktadır. Özellikle eğlence ve iletişim amaçlı kullanılan sosyal medya araçlarında kullanıcılar dijital kimliklerini oluştururken gerçek kimliklerini gizleyerek ya da olduğundan farklı göstererek etkili izlenim oluşturma taktikleri kullanabilmektedir. Konu hakkında yapılan benzer çalışmalar sosyal medya araçlarının bu amaçla kullanım oranının en yüksek olduğu yaş grubunun 18 yaş üzeri genç kuşak olduğunu göstermektedir. Bu nedenle araştırmamız, 18 yaş üstü üniversite öğrencilerinin dijital kimlik kullanım taktikleri ve etkili izlenim oluşturma stratejilerini inceleme amacıyla tasarlanmıştır. Araştırma, Erzincan Binali Yıldırım Üniversitesi’nde eğitim gören üniversite öğrencileri üzerinden yürütülmüştür. Ana kütle büyüklüğü dikkate alınarak örneklem büyüklüğüne karar verilmiş ve 408 üniversite öğrenicisinin kolayda örnekleme yöntemiyle seçildiği bir örneklem oluşturulmuştur. Araştırmada daha önce güvenirlik ve geçerlik çalışmaları yapılmış olan “Dijital Kimlik Ölçeği” ve “Değiştirilmiş Benlik Sunum Taktikleri Ölçeği” kullanılmıştır. Kullanılan ölçekler 5’li likert tipi ölçek biçimindedir. Ölçeklerden elde edilen sonuçlar yaş, cinsiyet ve gelir düzeyi değişkenleri dikkate alınarak analiz edilmiştir. Ayrıca katılımcıların tercih ettikleri sosyal medya araçları ve bu araçları kullanım amaçları da dikkate alınarak ilişkilendirme yapılmıştır. Elde edilen veriler SPSS 20 paket programında analiz edilmiştir. Araştırmanın verileri normal dağılım özelliği gösterdiği için analiz aşamasında t testi ve ANOVA testi kullanılmıştır. Araştırmadan elde edilen bulgular sosyal medya araçlarını kullanım amacı ile dijital kimlik geliştirme ve etkili izlenim oluşturma pratikleri arasında anlamlı bir ilişki olduğunu ortaya koymuştur.
Effects of Exogenous Lanthanum Nitrate on the Active Substance Content and Antioxidant Activity of Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes)
Authors: Gao Qi , Zhang Debin , Ding Wenjing , Zhai Wenjiao , Gu Chunmei , Guo Shaofen
Published: March 2023

Cordyceps militaris is a medicinal and edible mushroom. Researchers often add exogenous substances to the culture medium to increase the active substance content in C. militaris. However, the effect of earth elements on the active substance content in C. militaris and its antioxidant effects have not been reported. In this study, the active substance content in C. militaris treated with lanthanum nitrate was determined using high-performance liquid chromatography and ultraviolet spectrophotometry, and the effect on the antioxidant capacity of C. militaris after lanthanum nitrate spraying was further explored. The results showed that, in the experimental concentration range, the two concentrations of 10 mg/L and 50 mg/L had a significant influence on the active substance content of C. militaris. When the concentration of lanthanum nitrate was 10 mg/L, the synthesis of pentostatin and cordycepin was promoted. When the concentration of lanthanum nitrate was 50 mg/L, it significantly promoted the synthesis of cordycepin, and the ferric-reducing power and DPPH· scavenging rate of C. militaris treated at this concentration were significantly higher than those of the control group. However, lanthanum nitrate had no significant effect on ergosterol synthesis (P > 0.05). Finally, considering that the residual amount of lanthanum in C. militaris and the residual amount of lanthanum in 50 mg/L lanthanum nitrate-treated C. militaris is within the allowable daily intake of 4.2 mg for humans, the optimal concentration of lanthanum nitrate-treated C. militaris is 50 mg/L.
EXPERIMENTAL INVESTIGATION OF TWO-PHASE PRESSURE DROP IN THE STRAIGHT ADIABATIC TUBES
Authors: Kumar Arvind , Kothadia Hardik
Published: March 2023

The pressure drop is the significant constraint in designing the single or multiphase flow systems. Innovative technologies, such as nuclear power plants and enhanced oil recovery processes, can be designed more efficiently with the knowledge of the multiphase pressure drop phenomenon. The higher pressure drop induces the lower system efficiency. There is a scarcity of literature representing the steam-water flow at atmospheric system pressure in the adiabatic tubes. The experiments are performed to get the two-phase pressure drop in the adiabatic tube for the effective design of heat transfer equipment used for diverse applications. The adiabatic tubes of 8, 13.7, and 18 mm diameter, having 15 × 102 mm length, are experimented for 32-495 kg/m2s mass flux and 0-1 vapor quality. The pressure drop in the adiabatic tubes increases nonlinearly with the increase of vapor quality. The pressure drop is influenced significantly by the diameter of the tube. The pressure drop is lesser in the 18 mm tube compared to the 8 and 13.7 mm tubes for constant vapor quality and mass flow rate. The increase of the mass flux increases the pressure drop monotonically. The pressure drop is higher at higher mass flux and higher vapor quality in the lesser diameter tube. The experimental pressure drop is compared to various correlations. A correlation is suggested to measure the two-phase pressure drop during steam-water flow at atmospheric system pressure in the adiabatic tubes.
Brucellosis; Difficulty of Diagnosis in Endemic Areas
Authors: HAYKIR SOLAY Asli , KUŞCU Ferit , TÜTÜNCÜ Emin Ediz , DEDE Gülay , GÜRBÜZ Yunus
Published: March 2023

Introduction: Brucellosis is a zoonotic disease distributed worldwide and very important public health problem especially in the developing countries. In this study, we aimed to evaluate the clinical/laboratory findings of brucellosis patients and contribute of coombs testing to diagnosis at Iğdır State Hospital infection diseases and clinical microbiology department.
Materials and Methods: One hundred and forty-five brucellosis patients followed up in our clinic between September 2012 and February 2013 were evaluated retrospectively. Demographic characteristics, laboratory findings, diagnostic methods of the patients were presented.
Results: The mean age of the patients were 39±15 (18-80) and 59% (n=86) of the patients were female, 41% (n=59) were male. Most frequent risk factors were animal breeding (n=115, 79%) and using underdone milk and milk products (n=98, 69%). Most reported complaints were weakness (92%), arthralgia (89%), sweating (74%), lack of appetite (70%) and fever (68%). Fifty-seven of the brucellosis patients could not diagnosed with standard tube agglutination. Therefore, Coombs test was used for these undiagnosed patients (39%, n=57). Eighty patients were evaluated as acute (55%), 53 as subacute (37%) and 12 as chronic (8%) brucellosis.
Conclusions: Brucellosis can affect all organ systems and cause different clinical manifestations. Therefore, difficulties are encountered in the diagnosis of the disease. Brucellosis should be kept in mind in the differential diagnosis especially in the endemic regions. When the clinical suspicion exists detailed laboratory evaluation must be performed.