bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGEMBANGAN MEDIA WAYANG BEBER UNTUK MENINGKATKAN SIKAP NASIONALISME SISWA SD NEGERI BENDO 1 KABUPATEN BLITAR
Authors: Parawansa Rahajeng Intan , Fatih Mohamad , Alfi Cindya , Makrifah Istina Atul
Published: July 2024

Tujuan penelitian ini digunakan untuk mengetahui tingkat nasionalisme siswa kelas V UPT SD Negeri Bendo 01 Kabupaten Blitar terhadap media wayang beber. Penelitian ini dipraktekkan di UPT SD Negeri Bendo 01 Kabupaten Blitar pada bulan Oktober 2023. R&D, atau penelitian dan juga pengembangan ini merupakan kata yang digunakan untuk menggambarkan jenis metodologi penelitian ini. Kuesioner yang dibagikan kepada 22 siswa kelas V digunakan sebagai sampel. Penelitian ini melibatkan 22 siswa kelas lima sebagai partisipan. Hasil penelititian menujukkan bahwa tingkat Nasionalisme siswa tinggi dibuktikan dengan perolehan dari validasi ahli media dengan keseluruhan aspek memperoleh 95,4% dengan kriteria “Sangat Valid”, validasi dari ahli materi dengan keseluruhan aspek memperoleh 81,25% dengan kriteria “ Valid” Pengukuran kelayakan media wayang beber dari angket yang diberikan kepada guru memperoleh penilian dari keseluruhan aspek 97,5% dengan kriteria “ Sangat Layak”. Pengukuran respon siswa terhadap kemenarikan media dari keseluruhan aspek memperoleh persentase sebesar 98% memiliki kriteria “ Sangat Menarik”. Pengukuran angket peningkatan nasionalisme siswa dari seluruh aspek yang tertulis memperoleh persentase sebesar 98,1% dengan kriteria “ Peningkatan Tinggi”. Jadi dapat disimpulkan bahwa tingkat nasionalisme siswa setelah penggunaan media Wayang Beber materi tokoh-tokoh kemerdekaan Indonesia.
PENGEMBANGAN MODUL AJAR TEACHING ENGLISH AS A FOREIGN LANGUAGE BERBASIS COMMUNICATIVE LANGUAGE TEACHING SEBAGAI SARANA PENUNJANG KEGIATAN BELAJAR MAHASISWA
Authors: Rofiah Siti , Widiarini Widiarini , Arini Fitri , Nisak Winda Khoirun
Published: July 2024

Studi ini dilakukan sebagai bagian  dari upaya untuk mengembangkan modul mata kuliah Teaching English as a Foreign Language. Modul ini penting untuk menunjang capaian pembelajaran dan lulusan mahasiswa, terutama pada mahasiswa yang mengambl program studi Pendidikan Bahasa Inggris. Dalam kegiatan pembelajaran mata kuliah tersebut, mahasiswa merasa kesulitan memperoleh sumber informasi yang dapat menunjang kegiatan belajar mereka. Minimnya buku cetak dan rendahnya minat mahasiswa dalam mencari referensi di internet dan mendownload buku referensi untuk diunduh dan dicetak secara mandiri juga menjadi hambatan tersendiri dalam mendukung kelancaran suksesnya pengajaran Teaching English as A Foreign Language. Hasil dari penelitian ini dimaksudkan dapat membantu mahasiswa dalam mengatasi kesulitan tersebut dengan cara mengembangkan modul ajar Teaching English as A Forein Language sebagai sarana penunjang kegiatan belajar mahasiswa. Modul ajar ini diharapkan dapat menjadi solusi dari permasalahan siswa dan mendukung kegiatan belajar mereka. Hasil dari pengembangan modul ini menunjukkan bahwa modul layak digunakan untuk kegiatan pembelajaran dan mampu mendukung kegiatan belajar siswa
Alih Fungsi Bangunan Heritage Antico Coffee di Kota Bandung
Authors: Sajid Sriwinarsih Maria Kirana , Yuwono Astrid Austranti , Josephine Aracely
Published: July 2024

Bangunan peninggalan masa pemerintahan Hindia Belanda merupakan bagian dari perkembangan kota yang juga memperkaya khazanah arsitektur khususnya di Kota Bandung. Hal ini menjadikan bangunan peninggalan masa pemerintah Hindia Belanda, memiliki nilai sejarah tinggi serta estetika yang dapat menjadi referensi bagi ilmu desain dan arsitektur. Perubahan fungsi bangunan dilakukan sebagai upaya mempertahankan bangunan tersebut dengan kegiatan yang baru, sehingga mampu membiayai sendiri kelangsungan hidup bangunan konservasi tersebut. Antico Coffee mengalami alih fungsi beberapa kali dan pada saat penelitian dilakukan memiliki fungsi café. Objek penelitian terletak di area permukiman Bandung ‘baru’ yang dibangun sekitar tahun 1921-1924, memiliki tipologi bangunan pertokoan yang mirip dengan pertokoan Cihapit tempo dulu. Penelitian ini bertujuan untuk melakukan kajian evaluasi alih fungsi bangunan objek penelitian dalam lingkup arsitektural yakni elemen yang berhubungan dengan façade bangunan; elemen-elemen arsitektur dan interior; serta elemen struktur dan keteknikan bangunan. Metode penelitian berupa kualitatif deskriptif berdasarkan model evaluasi Alhojaly yang menilai aspek-aspek perubahan dan bagian bangunan yang perlu dipertahankan untuk mempertahankan identitas bangunan yang pemerintahan kolonial Hindia Belanda yang memiliki nilai sejarah. Karakter fisik bangunan tetap dipertahankan dengan membuat penembahan elemen bangunan yang telah hilang, untuk memunculkan dan memperkuat kembali karakter bangunan asli. Manfaat penelitian ini memberikan wawasan bagi masyarakat bahwa pelestarian dengan pendekatan alih fungsi dapat dilakukan dengan tetap mempertahankan bahkan memperkuat identitas elemen bangunan warisan budaya.
The Effects of Sensor and Feature Level Fusion Methods in Multimodal Emotion Analysis
Authors: Hatipoğlu Yılmqz Bahar , Köse Cemal
Published: July 2024

Fusion-based multimodal emotion recognition (MER) studies are very popular nowadays. In this study, EEG signals and face images are fused with sensor level fusion (SLF) and feature level fusion (FLF) methods for multimodal emotion recognition. The general flow of the study is as follows. Firstly, EEG signals are converted into angle amplitude graph (AAG) images. Secondly, the most unique ones are automatically identified from all face images obtained from video recordings. Then, these modalities are fused separately using SLF and FLF methods. The fusion approaches were used to combine the obtained data and perform classification on the integrated data. The experiments were performed with the publicly available DEAP dataset. The highest accuracy was 82.14% with 5.26 standard deviations for SLF and 87.62% with 6.74 standard deviations for FLF. These results show that this study makes a significant contribution to the field of emotion recognition by providing an effective method.
Sob uma Perspectiva Decolonial: Análise de Unidades de História e Natureza da Ciência de Livros Didáticos do PNLD 2021
Authors: Pereira Luely Miguel , Ibraim Stefannie de Sá
Published: July 2024

A educação brasileira está vinculada ao projeto colonial. Assim, é necessário adotar abordagens pedagógicas que busquem superar essa realidade. Este trabalho propõe uma reflexão sobre como três coleções de livros didáticos de Ciências da Natureza, do Ensino Médio, nas unidades referentes à história e natureza da ciência, atuam na preservação da colonialidade e/ou como age para superá-la. Para isso, questionamos: quais traços de colonialidade/decolonialidade estão presentes em livros didáticos de Ciências da Natureza, aprovados pelo Programa Nacional do Livro e do Material Didático 2021? Como esses traços são manifestados? Realizamos uma Análise de Conteúdo sob uma perspectiva decolonial. Observamos a presença dos seguintes traços de colonialidade: hierarquização e silenciamento de conhecimentos; caracterização da ciência moderna ocidental como universal e único conhecimento válido para ser propagado na educação formal. Salientamos evidências de pequenos progressos, como a citação de povos não-europeus. Concluímos que não há livro totalmente alinhado às discussões propostas por uma educação científica decolonial, apesar de ser possível observar alguns avanços em determinadas coleções. Reconhecer tais traços é um importante passo rumo à construção e estabelecimento de uma educação científica decolonial, pois a partir disso é possível escrever novas histórias e almejar outros futuros possíveis. Logo, fomentamos discussões sobre como os LD estão lidando com elementos decoloniais.
Foundations of Metaphysics
Authors: Kulieshov A.V.
Published: July 2024

Metaphysics is the branch of philosophy that investigates the Universe from the most general and abstract point of view. Such a perspective supports a systematic vision of the subject under investigation. The book provides an account of the system of world's realities in metaphysical terms, which may serve as the foundations of metaphysics. The specificity of the presented metaphysical system arises from its method of representation. All the elements of this system are produced by applying just one basic metaphysical formula. Its reiteration reveals the full spectrum of existence, beginning with the most abstract entities and culminating in the most concrete objects. The book can be useful to both students of metaphysics and experts, as well as anyone interested in the problems concerning the Universe in which we exist.
Neuroplasticity in the use of a human glucone-like peptide-1 analog in an obese patient: clinical case
Authors: Matveeva M. , Samoilova I. , Oleynik O. , Kudlay D. , Podchinenova D. , Apalkov D.
Published: July 2024

This clinical case reflects a variety of symptoms in obesity with central nervous system involvement. At the same time, the use of liraglutide in an obese patient resulted not only in the reduction of visceral fat area, but also in the improvement of cognitive functions, reduction of neuropilin, and as a consequence, reversibility of neurometabolism and functional changes in the brain. Literature sources from international and Russian databases for 5 years were used to compare the results.
Silverman–Andersen respiratory scale in a comprehensive assessment of respiratory distress syndrome of premature newborns: clinical and prognostic role in the early neonatal period
Authors: Zavyalov O. , Ilyenko L. , Ignatko I. , Pasechnik I. , Dolgikh V. , Babaev B. , Kuznetsova E. , Gorbacheva Е.
Published: July 2024

The article provides epidemiology, main international recommendations and domestic clinical experience of the early use of the Silverman–Andersen respiratory scale in the comprehensive assessment of neonatal respiratory distress syndrome (NRDS). The modern anatomical and histological prerequisites and clinical and pathophysiological features of respiratory failure, pathognomonic for the development of NRDS in the early neonatal period, are considered. The important clinical and prognostic role of the initial use of the Silverman–Andersen scale in assessing the development/progression of NRDS in premature infants of small gestational age with the targeted choice of starting non-invasive ventilation in the conditions of the neonatal intensive care unit of the maternity hospital of the perinatal center of the S.S. Yudin City Clinical Hospital (Moscow).
Comparison of EEVEE and Cycles Rendering Performance in Blender 3.5 in the Context of Interactive Visuals for 3D Animation
Authors: Yulia Aviv Fitria , Zulkifli  , Bintoro Panji , Andini Dwi Yana Ayu , Triloka Joko
Published: July 2024

This research aims to compare the performance of two rendering engines, namely EEVEE and Cycles, available in Blender 3.5, in the context of developing interactive visual 3D animation. The rendering engine is a key element in 3D animation production, and the right choice between EEVEE and Cycles can have a significant impact on the final animation result. In this research, we conducted a series of experiments and analyzes to evaluate rendering speed, the quality of the resulting images, and the ability to achieve the visual effects desired by the animator. The results of this research provide deep insight into the strengths and limitations of each rendering engine in interactive 3D animation scenarios. These findings can help animators, game developers, and similar creative professionals make more informed choices when choosing a rendering engine that suits their project needs. Thus, this research contributes to the development of rendering techniques in the growing 3D animation industry.
Development of Android-Based Interactive Media Articulate Storyline 3 in IPAS Subjects Fourth Grade
Authors: Auvisena Arlinta Ulfa , Fathurrahman Moh.
Published: July 2024

This study aims to develop educational materials using Articulate Storyline, an e-learning software known for its practicality in creating interactive learning materials. This program is very helpful because it has an intuitive and easy-to-operate interface, which allows teachers and curriculum creators to design materials without requiring special skills in programming or graphic design. The methodology used in this study is Research and Development (R&D), following the ADDIE model which includes analysis, design, development, implementation, and evaluation. Data collection involves both test and non-test methods, and data is analyzed through quantitative as well as qualitative approaches. The results showed that the use of Articulate Storyline is very effective in learning natural and social sciences for grade IV students. This is evident from the high assessment by material and media experts, respectively by 91% and 90%. A significant increase in test scores from 55 to 80 and an increase in students' n-gain of 0.57 demonstrate the effectiveness of this tool in the teaching and learning process. Thus, Articulate Storyline is considered an ideal and effective tool for interactive learning in grade IV science subjects.
Development of Learning Tools Social Emotional Defense to Improve Learning Outcomes and Critical Thinking Skills in Human Reproductive System Materials in SMP Negeri 2 Intu Lingau
Authors: Manurung Raja Pagarlan , Boleng Didimus Tanah , Lumowa Sonja V. T. , Akhmad  , Sukartiningsih  , Daru Taufan Purwokusumaning , Maasawet Elsje Theodora , Rambitan Vandalita
Published: July 2024

This study uses the type of development research by adapting the model designed by Borg and Gall (1983) by making modifications. This research developed a product in the form of a learning plan of the Human Reproductive System material with the application of social Emotional Competency (KSE) differentiation learning which was developed specifically with the hope of increasing learning outcomes and critical thinking skills of class IX students in the subject of the reproductive system at SMP Negeri 2 Intu Lingau, West Kutai Regency. The development procedure in this study includes seven stages, namely the preliminary stage, planning, developing the initial product form, initial field testing, main product revision, final product testing, and dissemination. The research instruments used in this study were: Questionnaire sheets validating the assessment of science learning tools, Questionnaire sheets for social emotional attitudes, observation sheets for the implementation of learning, and giving test questions. This development research used Aiken’s V data analysis technique to determine the validation value of learning tools and determine the student Gain to analyze students thinking skills. From the results of this study it was found that science learning tools with social emotional competence (KSE) which include syllabus, lesson plant, worksheets, assessment instruments, and teaching materials about the human reproductive system are appropriate based on the value of Aiken’s V validation coefficient. Development of learning Outcomes significantly in the experimental class based on the gain scores obtained.
The Effect of Applying the Teaching at the Right Level (TaRL) Approach Assisted by LKPD to Improve the Learning Outcomes of Grade 6 Elementary School Students on Electrical Circuits
Authors: Aryanti Nurida , Muthamainah
Published: July 2024

The research aims to examine the effect of implementing the Teaching at the Right Level (TaRL) approach assisted by LKPD to improve the learning outcomes of grade 6 elementary school students on electrical circuits. The research was carried out at SDN 1 Semangkak on class VI students. The sampling technique uses a purposive area sampling method. The research used a quasi-experimental design with data collection techniques through post-tests in the form of multiple choice questions and descriptions, observation, documentation and interviews. The data obtained was analyzed using statistical tests which included normality tests, data analysis using the Paired Samples t-Test. Based on the Validity Test, the results show r = 0.82 α >(0.05) so that all question items show valid results. Reliability test if the value α > 0.738 the value is reliable, namely 0.894. Then the results of the normality test value of learning outcomes are 0.467 > α (0.05) exceed the significant value, then the variable values are normally distributed, followed by using the Paired Sample t-Test test, the test results -t is the learning result at a sig value of 0.00 < α (0.05), so reject H0. So it can be concluded that there is an influence of implementing the Teaching at the Right Level (TaRL) approach assisted by LKPD to improve the learning outcomes of Grade 6 Elementary School students on electrical circuits.
Electronic Based Practicum Guide Using Inquiry Models to Improve Science Process Skills and Student Learning Outcomes
Authors: Dewi Utari Prisma , Syafriani
Published: July 2024

Low science process skills also result in low learning outcomes. So the solution is to develop an electronic-based practicum guide using an inquiry model on measurement material. This research aims to develop an electronic-based practicum guide using an inquiry model on measurement material to improve science process skills and student learning outcomes. The development model is the ADDIE model. The research instruments used were expert and practitioner validation questionnaires, student response assessment questionnaires and pretest-posttest results. Data was analyzed quantitatively descriptively. The results of the N-gain test are 16 students who got a score of (g) ≥ 0.7, 14 students who got a score of (g) ≥ 0.3, and 14 students who got a score of (g) <0.3 as many as 0 people. Based on the results of this research, it can be concluded that electronic-based practicum guides using inquiry models in measurement material can improve science process skills and student learning outcomes.
Interaction of Sambiloto (Andrographis paniculata) Bioactive Compound with Milk Protein (Whey and Casein) Through Molecular Docking and Molecular Dynamics Simulation as a Basis for Encapsulation
Authors: Rahayu Premy Puspitawati , Sawitri Manik Eirry , Setiawan Dwi , Yunita Citra Nurma
Published: July 2024

This research aims for developing immune-boosting products necessary. The active ingredient in Andrographis paniculate (AP) acts as an immunostimulant which can improve the work of the immune system. The first stage of research was a collection of bioactive compounds from KnapSack database of Kanaya, Dr. Duke's Phytochemical and Ethnobotanical were compiled and selected based on the online pass results of each bioactive compound as an immunomodulator and 10 active compounds were obtained which will be continued. The second stage of research was a docking molecular between whey proteins (β-lactoglobulin and α-lactalbumin) with active compounds from AP and casein (α-Casein, β-Casein, and κ-Casein). The highest binding affinity was obtained for α-Casein with Neoandrographolide at -9.2 Kcal/mol. The results of the complex α-Casein with Neoandrographolide (CC) and α-Casein with Neoandrographolide ultraheat (CCT) support the research, namely to function α-Casein as an encapsulant well as a transporter or drug delivery of Neoandrographolide without changing the conformation of casein and disturbing its function. However, the conformation of casein will change drastically during ultraheat treatment to maintain the conformation and binding with the Neoandrographolide ligand. In addition, it supports the simulation results of single α-Casein at ultraheat temperatures which show conformational stability that is not much different from single α-casein and complexes at physiological temperatures
E-Module Development Using the Canva Application on Environmental Pollution Concept
Authors: Putra Andika Wijaya , Lamangantjo Chairunnisah J. , Uloli Ritin
Published: July 2024

This research uses the ADDIE development model to produce an E-Module using the Canva application on environmental pollution concept that is Valid, Practical, and Effective. This research was conducted at SMP Negeri Molibagu involving students in Class VII. The research results show that the results of the validation of the E-Module using the Canva application from media experts achieved a score of 85%, which is included in the valid category and suitable for use in learning. The practicality of the E-Module using the Canva application as shown by the implementation of learning during three meetings with a percentage of 85% with excellent category, and the student responses reached 83% with excellent criteria. The effectiveness of the E-Module using the Canva application is demonstrated by student activity with a percentage of 86% with good criteria. Thus, it is concluded that the E-Module using the Canva application on environmental pollution concept has met the valid, practical, and effective criteria.
Analysis of Residential Well Water Quality Around People's Gold Mines in the Tourist Area of Dusun Selindungan
Authors: Rahayu Rachmawati Noviana , Suripto  , Ahyadi Hilman
Published: July 2024

The Sekotong area has natural charm and potential mining. This area is one of the preferred destinations for visits by local and foreign tourists. However, apart from that, the Sekotong area is also famous as a community gold mining area. Mining activities carried out still use traditional methods, which are very far from environmentally friendly principles, so they can have impacts, including causing a decrease in the quality of residential well water. This research was conducted to determine the water quality of residential wells around community gold mining in the tourist area of Dusun Selindungan Eleven well water samples were taken using a purposive sampling method based on the distance of the well to the source of gold mining waste disposal and are still used by residents to meet their daily needs. Physical, chemical and biological water quality parameters of water samples were investigated in the laboratory, except temperature and pH were measured directly in the field. Data for each water quality variable was analyzed to determine the pollution index. The results show that DO, TDS, content of phosphate, E. Coli bacteria and total coliforms in well water from the study area generally exceed quality standardsWell water in an area that is a different distance from the people's gold mining waste disposal site has each been contaminated with manganese and mercury, although it is still below quality standards.
Preliminary Study on Potential Bacterial Species Introducing Antibacterial Agent from Sponge in Unggeh Island Central Tapanuli, Indonesia
Authors: Abdillah Latifah Ningrum , Suryanto Dwi , Nurtjahja Kiki , Mamangkey Jendri
Published: July 2024

Sponges have the potential to symbiont with bacteria that produce antibacterial compounds. This study was conducted to isolate and test the antibacterial activity of sponge symbiont bacteria. Bacterial isolates obtained were tested for antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli using the Kirby-Bauer method. The identification results of both sponges have similarities with Clathria sp. and Hyrtios sp. symbiont bacteria obtained from both sponges as many as 16 isolates. Antibacterial activity testing had a weak inhibitory effect on isolates Sp1A, Sp2C, Sp2D and Sp2F, while Sp2J showed moderate inhibition against gram-negative and positive bacteria. The antibacterial activity of the whole supernatant of symbiont bacteria obtained the diameter of the inhibition zone with weak, medium and strong categories. Sp1A isolate supernatant was obtained, potentially able to fight Escherichia coli bacteria with a strong category as a representation of gram-negative bacteria and against gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) classified into the medium category. In conclusion, 16 symbiont bacterial supernatants have antibacterial activity mostly active against gram-negative bacteria Escherichia coli and gram-positive bacteria Bacillus subtilis. There are 6 isolates (Sp1A, Sp1B, Sp1E, Sp1F, Sp2D, Sp2F) active as antibacterial against Staphylococcus aureus with weak and moderate categories.
Validity of Creative Interactive-Web and Seamless Learning Media and Learning Models to Improve Students' Creative Thinking Skills and Cognitive Learning Outcomes in High School Biology Subjects
Authors: Suharti Dyah Istami , Tukiran  , Raharjo
Published: July 2024

This research aims to determine the validity of the Creative Interactive - Web And Seamless (CRI-WES) media and learning model. Development in this research uses the Wademan model which has five stages of development, namely problem identification, identification of tentative products and design principles, tentative products and theories, prototyping and initial product and theory assessment, and problem solving and theory development. The results of the biology education expert's validity analysis for content and construct validation showed a reliability percentage of 100% (R>75%). Biology education experts' validation of learning tools is included in the category of very valid, valid and sufficient to support learning with the CRI-WES model. Shows that the assessment tools and instruments are truly valid for use and do not require revision. This research produces an innovative learning model that is valid and can be used to assess practicality and effectiveness. This can also be applied to improve students' creative thinking abilities and cognitive learning outcomes in biology subjects at the high school level.
Trends Research Project Based Learning (PjBL) Model to Improve Problem Solving Skills in Students' Science Learning (2015-2024): A Systematic Review
Authors: Doyan Aris , Harjono Ahmad , Qadafi Moammar
Published: July 2024

Problem-solving ability is an important ability for students to have in science learning. With the ability to solve problems, students' critical, logical, and creative thinking skills can increase. Problem solving skills can be facilitated through learning with a project-based learning (PjBL) model. This research aims to identify and analyze research trends of PjBL model to improve problem solving skill in science learning. This research method is descriptive and analytical. The data used in this research was obtained from documents indexed by Google Scholar from 2015-2024 using Publish or Perish and Dimension.ai. Research procedures use PRISMA guidelines. The data identified and analyzed are the type of publication, publication source, and the title of research on PjBL model to improve problem solving skill in science learning that is widely cited. The data analysis method uses bibliometric analysis assisted by VOS viewer software. The results of the analysis show that research trend on PjBL model to improve problem solving skill in science learning indexed by Google Scholar from 2015 to 2024 has experienced a fluctuating increase. However, in 2024 there will be a decline in the research trend on it. There are many documents in the form of articles, proceedings, chapters, preprints and edited books that discuss research into the PjBL model to improve problem solving skill in science learning. Key words that are often used in research about it are STEM project, creative thinking skill, technology, critical thinking, discovery, etc.
Pengaruh Bahan Ajar Berbasis Teknologi pada Pembelajaran IPAS Materi Sifat-sifat Cahaya Terhadap Kemampuan Berpikir Kritis Siswa
Authors: Ulinuha Widda , Nurwati Agie , Chaeratunnisa Elsa , Zahra Agustina Shofia , Leksono Suroso Mukti
Published: July 2024

Tujuan penelitian ini adalah untuk mengetahui bagaimana bahan ajar berbasis teknologi mempengaruhi kemampuan berpikir kritis siswa saat belajar materi sifat-sifat cahaya di IPA. Penelitian ini menggunakan metode eksperimen. Metode eksperimen dipilih karena memungkinkan peneliti untuk mengontrol semua variabel yang terlibat dan menentukan hubungan sebab-akibat antara penggunaan bahan ajar berbasis teknologi dan peningkatan kemampuan berpikir kritis siswa. Hasil penelitian menunjukkan efektivitas penggunaan bahan ajar berbasis teknologi. Tabel statistik menunjukkan bahwa nilai rata-rata post-test untuk kelas eksperimen adalah 81,25, sedangkan kelas kontrol memperoleh nilai rata-rata 66,88. Hal ini mengindikasikan bahwa siswa yang belajar dengan bahan ajar berbasis teknologi memiliki kemampuan berpikir kritis yang lebih baik dibandingkan dengan siswa yang menggunakan metode pembelajaran konvensional. Dengan demikian terdapat pengaruh yang signifikan penggunaan bahan ajar berbasis teknologi terhadap kemampuan berpikir kritis siswa. Implementasi strategi ini tidak hanya meningkatkan hasil belajar tetapi juga memotivasi siswa melalui metode pembelajaran yang lebih menarik dan relevan dengan perkembangan teknologi saat ini.
Detection of counterfeit images using SIFT and PNN
Authors: Javier-A-Rodríguez-Herrejón  , Enrique-Reyes-Archundia  , Jose-A.-Gutiérrez-Gnecchi  , Arturo-Mendez-Patiño  , Juan-C.-Olivares-Rojas
Published: July 2024

Manipulation of digital images presents a significant challenge, primarily due to the continuous advancement and sophistication of image enhancement tools. As a consequence, image feature extraction and matching have become pivotal areas of research in the field of image processing. Among the various techniques developed, the Scale-Invariant Feature Transform algorithm has gained widespread recognition for its robustness and superior performance in feature matching tasks when compared to other existing methods. In this context, our proposed method, which integrates the Scale-Invariant Feature Transform algorithm with a probabilistic neural network, offers a novel approach to digital image classification specifically aimed at counterfeit image detection. This integrated system not only enhances the accuracy of feature extraction but also leverages the probabilistic neural network to improve classification efficacy. Empirical results indicate that this hybrid approach achieves a remarkable relative error rate of just 0.666%, underscoring its potential as a reliable tool for combating digital image forgery. Such advancements are crucial for maintaining the integrity of digital media in various applications, from forensic analysis to digital content authentication.
Mirtazapine in Primary Insomnia: Case report and Literature review
Authors: Asad Riaz  , Qandeel Shahid  , Hafiz Mansoor Yousaf  , Usama Gul  , Syed Saifullah Shah  , Aabdar Hidayat  , Tauseef Hamid  , Anees Ur Rahman  , Muhammad Usman  , Muhammad Kinwan Khan  , Rafia Muhtiar  , Behram Khalid
Published: July 2024

Introduction: Insomnia is a prevalent sleep disorder characterized by difficulty in falling asleep, maintaining sleep, or achieving restorative sleep, despite adequate opportunities. This condition often results in significant daytime impairments, including fatigue, concentration difficulties, and irritability. Insomnia can be primary or comorbid with other disorders such as anxiety or depression. Case Presentation: A 27-year-old woman presented with severe and chronic insomnia, persisting for 14 years with recent exacerbation. Her symptoms included significant difficulty in initiating and maintaining sleep, resulting in an average of only 3-4 hours of sleep per night and complete sleep deprivation for periods exceeding half an hour over the past 5 days. This sleep deficit led to pronounced emotional instability, physical discomfort, and reduced appetite, although suicidal ideation was absent. She had a past history of drug use for different psychiatric illnesses. She was started on mirtazipine 30mg and showed abrupt improvement in her symptoms. She was discharged afterwards. Discussion: The patient's chronic insomnia and its secondary effects necessitate a comprehensive treatment approach. Mirtazapine, an antidepressant with potent histamine receptor antagonism, has shown efficacy in improving sleep quality across diverse patient profiles. However, side effects like weight gain and sedation require careful monitoring. Combining mirtazapine with prolonged-release melatonin has demonstrated enhanced outcomes, particularly in perimenopausal women. Cognitive Behavioral Therapy for Insomnia (CBT-I) remains the first-line treatment due to its efficacy and long-term benefits. Conclusion: Mirtazapine can be a valuable option in the therapeutic arsenal for primary insomnia, but ongoing research is needed to refine treatment strategies. Personalized treatment plans considering patient history and response are crucial for effectively managing primary insomnia and improving patient outcomes.
5 • Archaeology in the Largest Realm: A Prelude to Exploiting Potential
Authors: Bombardieri Luca
Published: July 2024

Presenting the large eastern island to the western reader meant proposing itineraries, describing its fauna and flora, ports and markets, designing routes enriched with anecdotes. But it also meant questioning the relationship between present and past, between present-day Cypriots and classical Greece.
Cixous avec Deleuze: écriture en corps et devenir-femme
Authors: Martin Alexandre
Published: July 2024

Roberto Esposito a mis en lumière le nouveau paradigme politique de notre modernité : l’immunité. Celle-ci, bien que nécessaire à la constitution du commun, se retourne aujourd’hui en son contraire et risque de détruire ce qu’elle est censée protéger. La biopolitique se renverse alors en thanatopolitique comprise comme politique sans dehors. A travers la lecture expérimentale que Deleuze propose de Cixous, apparaît la possibilité, voire la nécessité, de penser une nouvelle forme de communauté qui repose moins sur le pouvoir que sur une puissance entièrement repensée, en l’occurrence une puissance de l’amour ouverte sur le dehors. Celle-ci trouve son expression dans un style d’écriture matricielle et maternelle que Cixous a élaboré à travers la théorie et la pratique de l’écriture-femme qu’elle développe dans ses essais et romans des années 1970. Nous tenterons ainsi de questionner le lien qui existe entre l’écriture-féminine de Cixous et le devenir-femme de Deleuze afin d’expérimenter de nouveaux gestes du politique –compris comme institution du commun– où la différence est accueillie davantage que rejetée.
Bad Plants
Authors: Sullivan Heather
Published: July 2024

“Bad plants” represent the seemingly unexpected and startling forms of plant power overlooked by many modern, industrialized societies that treat vegetal beings as mere resources instead of animate, world-shaping forces. Since science fiction and fairy tales often explore more openly animistic visions of non-human life, such texts provide ample possibilities for reconsideration by critical plant studies of our human-plant relations both cultural and ecological. For example, both Jack McDevitt’s 2001 science fiction novel, Deepsix, and Ludwig Tieck’s 1799 fairy tale, “Faithful Eckart and Tannhäuser”, feature “bad plants” that bring human beings violently back into the plant cycles they assume they have left behind with advanced culture and/or technology. In McDevitt’s case, we find sexualized predatory flowers on an alien planet, and in Tieck’s, flower-filled caves containing Venus herself living deep in the forested mountain. The wildly sexual blossoms lure human beings back into their botanical cycles, thereby expressing and, simultaneously, hiding our ecological embeddedness that is actually quite mundane. The lurid visions of “bad plants” contain potentially profound, if convoluted, ecological truths about our full dependence on, and ongoing immersion within, the activities of the domineering green photosynthesizers.
Nuevas tendencias en la literatura del colapso medioambiental
Authors: Andrade PIlar
Published: July 2024

Este artículo aborda las nuevas tendencias de la literatura del colapso medioambiental, contextualizándolas mediante estudios teóricos recientes sobre el tema (colapsología, Extinction Studies, antropología simétrica de Bruno Latour, catastrofismo ilustrado de Jean-Pierre Dupuy). Se delimita el corpus de estudio a partir de tres características básicas, articuladas desde la intención realista: la modalidad de lo imposible cierto, abundancia de datos y un cronotopo próximo. Se analizan textos literarios con esas características y orientados hacia una finalidad constructiva, de autores en lengua inglesa y francesa.
“They settle down on us / they dwell within”: A. M. Pires Cabral’s Attunement with Birds
Authors: Fernandes Alves Isabel Maria
Published: July 2024

Recent studies prove that imagination is a constructive process that transports the reader from one place to another, from one time to another, offering the possibility to inhabit another consciousness. To interpret, which in itself is an act of attention, opens a door to otherness, to kinship and empathy, asking from us affective responses towards human and nonhuman others. Drawing upon an ecocritical perspective, this paper considers how the depiction of birds in A. M. Pires Cabral’s poetry illustrates the way human dialogue with the nonhuman is a powerful tool in contemporary rediscovery of nature. The paper argues that by thinking with birds, the poet transforms not only his own self, but also the way readers envision the nonhuman other. Although Cabral’s passion for birds is not unique but part of a tradition that goes back to medieval bestiaries, I argue that at a time of biodiversity rarefaction his poetic depiction of birds is an expression of the human affection attuned to the more-than-human world; mostly, however, this paper invites discussion on the poet’s multilayered affection for birds as a result of his recognition that thinking with birds prompts, ultimately, deeper thinking about human beings.
Исследование биологической активности in silico и in vitro 5-замещенных производных N1-карбоксиметил-5-фторурацила – потенциальных пролекарств 5-фторурацила
Authors: Черникова Инна Борисовна , Нуриева Эвелина Рашитовна , Ишметова Диана Валиевна , Вахитов Венер Абсатарович
Published: July 2024

Рассчитана вероятная цитотоксическая активность, вероятная гематотоксичность, вероятная острая токсичность при пероральном введении мышам (LD50 mouse oral ASNN) ранее синтезированных 5-замещенных (Br, Cl, NO2) производных N1-карбоксиметил-5-фторурацила. По полученным расчетным данным, все соединения проявляют высокую цитотоксическую активность и низкую вероятную острую токсичность при пероральном введении мышам. Следует отметить, что в результате исследования цитотоксической активности in vitro (PrestoBlue, Invitrogen) обнаружено, что указанные соединения не проявляют цитотоксической активности в отношении клеточных линий условно-нормального и опухолевого происхождения. Продемонстрированная низкая цитотоксичность данных соединений по результатам опытов in vitro позволит использовать их в достаточно высокой концентрации, по сравнению с 5-фторурацилом, в дальнейшем для исследований in vivo.
Определение содержания салицина в листьях тополя белого методом ВЭЖХ
Authors: Куркин Владимир Александрович , Косенко Анна Александровна , Куркина Анна Владимировна
Published: July 2024

Из листьев тополя белого (Populus alba L.) с использованием колоночной хроматографии выделены изокверцитрин, 3-О-β-D-глюкопиранозид изорамнетина, салицин и 6’-О-кофеоил-салицин, который является новым природным соединением. Разработана методика количественного определения содержания доминирующего фенольного гликозида — салицина в листьях тополя белого методом ВЭЖХ. Содержание салицина в листьях тополя белого варьирует от 3,19 ± 0,08 % до 7,73 ± 0,01 %. Ошибка единичного определения содержания салицина в листьях тополя белого с доверительной вероятностью 95 % составляет ± 5,51 %.
Разработка технологии получения пэгилированного филграстима и изучение его физико-химических и биологических свойств
Authors: Лоншаков Дмитрий Владимирович , Шереметьев Сергей Викторович , Бобрышева Ирина Вячеславовна , Гребенникова Ольга Александровна , Хурсевич Елена Михайловна , Коровкин Сергей Анатольевич
Published: July 2024

С целью получения препарата пэгилированного Филграстима, кандидата на импортозамещение препарата «Неуластим» на территории Российской Федерации, разработана технология эффективного пэгилирования Филграстима, основанная на реакции восстановительного аминирования пэгилирующего реагента с молекулярной массой 20 кДа, несущего концевую карбонильную группу, белком с использованием цианборгидрида в качестве восстановителя. С помощью изучения химической кинетики данного процесса подобраны наиболее оптимальные условия синтеза субстанции Пэгфилграстима и после многостадийной хроматографической очистки монопэгилированного конъюгата получено несколько серий препарата пэгилированного Филграстима. Подтверждена стабильность полученных серий препарата и показана его идентичность по специфической активности и физико-химическим параметрам препарату «Неуластим».
Методика оптико-электрохимического микробиологического тестирования в применении к оценке свойств различных эфирных масел
Authors: Сибирцев Владимир Станиславович , Нечипоренко Ульяна Юрьевна
Published: July 2024

Описана методика экспрессной оптико-электрохимической оценки про- и антибиотических свойств фармацевтической продукции, предусматривающая периодическую (в нашем случае через каждые 3 ч) инструментальную регистрацию изменений эффективности упругого светорассеяния, pH и электропроводности жидких питательных сред (в качестве которых нами использовался стерильный водный раствор с pH 7,2 ± 0,2, содержащий 20 г/л белкового гидролизата, 5 г/л глюкозы, 10 г/л сахарозы, 1 г/л лецитина и 2 г/л NaCl), инкубируемых в присутствии и в отсутствие жизнеспособных тестовых микроорганизмов и тестируемых образцов. Представлены результаты сравнительного анализа с помощью этой методики влияния на динамику жизнедеятельности Escherichia coli, выбранной нами в качестве типичного представителя микробиоты человека, разных концентраций (от 3 до 0,1 об. %) «эфирных масел», промышленно полученных перегонкой с водяным паром из 6 различных видов применяемого в фармацевтической промышленности растительного сырья. Проведенные исследования подтвердили, что представленная методика, в сравнении с ранее используемыми для подобных целей, позволяет более экспрессно, объективно и информативно, а также менее трудоёмко и материалоёмко оценивать влияние на динамику жизненной активности микроорганизмов различных образцов фармацевтической продукции. При этом было показано, что среди исследованных в этой работе образцов наиболее активные антимикробные свойства проявили «эфирные масла», полученные из корней чистотела и дягиля, а также листьев шалфея. При этом характер биологической активности исследованных образцов определялся не только составом присутствующих в них веществ, но и их концентрацией, с уменьшением которой антимикробная активность образцов уменьшалась, а также временем взаимодействия тестируемых образцов с тестовыми организмами, с увеличением которого биологическая активность образцов также уменьшалась. Результаты проведенного исследования могут найти применение при контроле качества уже существующей и разработке новой фармацевтической продукции, включающей в себя различные растительные субстанции.
Determination of stresses in dangerous cross-sections of frame spars of minitractor vehicles
Authors: Manoiylo Volodymir Manoiyl , Voronkov Oleksandr , Avramenko Andrii , Baitsur Maksim , Kozlov Yuriy
Published: July 2024

Problem. On the basis of the method of initial parameters, it is necessary to determine the mass-dimensional parameters of the frame of the spar type, for the creation of a universal small-sized vehicle UMTZ-26 "Nadia", as well as for the development of a mini-truck of category N1, with a carrying capacity of up to 3.2 tons. Goal. To determine the value of the maximum forces (stresses) and moments acting in the structural elements of the spar frame during the arrangement of the engine with transmission, body, engine compartment and cabin of the UMTZ-26 "Nadia" light vehicle, as well as units and aggregates of the N1 category, which can be used for  municipal city or farm purpose. Results. According to the given calculation using the method of initial parameters (for frame structures), the maximum load in the cross section of the selected channel is determined, which does not exceed 106.372 MPa, the latter is used as a spar in the welded frame of the vehicle. The maximum permissible load that this profile of the channel can withstand is 160 MPa. Originality. The drawing and design documentation of the spar type was developed, which was used for the development of new universal small-sized vehicles of the UMTZ-26 "Nadia" type, as well as for the creation of mini trucks of the N1 category. Practical value. The practical value lies in the fact that the values of the maximum forces and moments acting in the side members of the frame when the engine with transmission, the engine compartment and the cabin of the vehicle are arranged on it do not exceed the maximum permissible values and the latter can be used on mini motor vehicles of category N1.
Superposition principle of impact on the working environment of actuating elements for site preparation machines
Authors: Prystailo Mykola Prystailo , Balaka Maksym , Mozharivskyi Valentyn , Drachuk Volodymyr , Honta Ihor
Published: July 2024

Problem. The analysis of the ripper working elements designs showed that their improvement perspective direction is using vibration and impact actuating elements. They work by the principle of dynamic energy accumulation with its subsequent use. However, there are currently no approaches to determining the tip rational parameters with the dynamic cutting edge. Goal. The main hypothesis formation and justification of the superposition principle impact on the working environment of actuating elements for ripper-pick. Methodology. Analytical methods of studying the soil destruction process by site preparation machines equipped tip with a dynamic cutting edge were used. Results. The presented model that describes the soil destruction process by the tip with the dynamic cutting edge has been developed. It combines the work of static force, determined by the traction parameters of the base machine, and the work of dynamic forces, determined by the physical and mechanical conditions of the soil destruction process. As a result, we obtained an equation for determining the force to overcome soil cutting resistance by the tip with the dynamic cutting edge. Originality. We propose to apply the superposition principle of effecting several factors on the working environment simultaneously in the soil destruction process by ripper-pick, such as static and dynamic load, due to the possibility of energy accumulation with subsequent use. This would create the high-speed power pulse on the cutting edge to ensure the preliminary formation of the compressed zone in the massif, with decreases in the power intensity of the static load for complete separation of the soil element. Practical value. The presented hypothesis will allow the technological basis development of such systems creation and application to develop fundamentally new technical solutions, to create effective, safe and durable working elements.