bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamical model of antibiotic responses linking expression of resistance to metabolism explains emergence of heterogeneity during drug exposures
Authors: Stevanovic Mirjana , Teuber Carvalho João Pedro , Bittihn Philip , Schultz Daniel
Published: September 2023

Antibiotic responses in bacteria are highly dynamic and heterogeneous, with sudden exposure of bacterial colonies to high drug doses resulting in the coexistence of recovered and arrested cells. The dynamics of the response is determined by regulatory circuits controlling the expression of resistance genes, which are in turn modulated by the drug’s action on cell growth and metabolism. Despite advances in understanding gene regulation at the molecular level, we still lack a framework to describe how feedback mechanisms resulting from the interdependence between expression of resistance and cell metabolism can amplify naturally occurring noise and create heterogeneity at the population level. To understand how this interplay affects cell survival upon exposure, we constructed a mathematical model of the dynamics of antibiotic responses that links metabolism and regulation of gene expression, based on the tetracycline resistancetetoperon inE. coli. We use this model to interpret measurements of growth and expression of resistance in microfluidic experiments, both in single cells and in biofilms. We also implemented a stochastic model of the drug response, to show that exposure to high drug levels results in large variations of recovery times and heterogeneity at the population level. We show that stochasticity is important to determine how nutrient quality affects cell survival during exposure to high drug concentrations. A quantitative description of how microbes respond to antibiotics in dynamical environments is crucial to understand population-level behaviors such as biofilms and pathogenesis.
Females translate male mRNA transferred during mating
Authors: Matzkin Luciano M. , Bono Jeremy M. , Pigage Helen K. , Allan Carson W. , Diaz Fernando , McCoy John R. , Green Clinton C. , Callan Jeffrey B. , Delahunt Stephen P.
Published: September 2023

Although RNA is found in the seminal fluid of diverse organisms, it is unknown whether this RNA is functional within females. Here, we develop an experimental proteomic method called VESPA (VariantEnabledSILACProteomicAnalysis) to test the hypothesis thatDrosophilamale seminal fluid RNA is translated by females. We find strong evidence for 67 male-derived, female-translated proteins (mdFTPs) in female lower reproductive tracts at six hours postmating, many with predicted functions relevant to reproduction. Gene knockout experiments indicate that genes coding for mdFTPs play diverse roles in postmating interactions, with effects on fertilization efficiency, and the formation and persistence of the insemination reaction mass, a trait hypothesized to be involved in sexual conflict. These findings advance our understanding of reproduction by revealing a novel mechanism of postmating molecular interactions between the sexes that strengthens and extends male influences on reproductive outcomes in previously unrecognized ways. Given the diverse species known to carry RNA in seminal fluid, this discovery has broad significance for understanding molecular mechanisms of cooperation and conflict during reproduction.
In vivoevaluation ofClostridioides difficileenoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy
Authors: Dureja Chetna , Rutherford Jacob T. , Pavel Fahad B. A. , Norseeda Krissada , Prah Isaac , Sun Dianqing , Hevener Kirk E. , Hurdle Julian G.
Published: September 2023

Clostridioides difficileinfection (CDI) is a leading cause of hospital-acquired diarrhea, which often stem from disruption of the gut microbiota by broad-spectrum antibiotics. The increasing prevalence of antibiotic-resistantC. difficilestrains, combined with disappointing clinical trials results for recent antibiotic candidates, underscore the urgent need for novel CDI antibiotics. To this end, we investigatedC. difficileenoyl ACP reductase (CdFabK), a crucial enzyme inde novofatty acid synthesis, as a drug target for microbiome-sparing antibiotics. To test this concept, we evaluated the efficacy andin vivospectrum of activity of the phenylimidazole analog 296, which is validated to inhibit intracellularCdFabK. Against major CDI-associated ribotypes 296 had an MIC90of 2 µg/ml, which was comparable to vancomycin (1 µg/ml), a standard of care antibiotic. In addition, 296 achieved high colonic concentrations and displayed dosed-dependent efficacy in mice with colitis CDI. Mice that were given 296 retained colonization resistance toC. difficileand had microbiomes that resembled the untreated mice. Conversely, both vancomycin and fidaxomicin induced significant changes to mice microbiomes, in a manner consistent with prior reports.CdFabK therefore represents a potential target for microbiome-sparing CDI antibiotics, with phenylimidazoles providing a good chemical starting point for designing such agents.
A Complex Containing the Na+/K+ATPase Regulates Epileptogenesis inDrosophila melanogaster
Authors: Bermudez Sarah , Dean Derek M. , Alkin Victoria , Wang Ziming , Pham Huy , Kondo Emily , Amini Andrew , Deitcher David L.
Published: September 2023

Epileptogenesis, the process through which the brain becomes seizure-prone, is not well understood. Previous work identified a novel gene inDrosophila,julius seizure(jus), that when mutated or developmentally knocked down, leads to epilepsy in adultDrosophila, providing a useful model for dissecting epileptogenesis. Here we report that when a GFP-tagged version of Jus was used as bait in a co-immunoprecipitation (co-IP) assay, a complex of 23 associated proteins was identified that included ATPalpha and Nervana 3, two subunits of the Na+/K+ATPase. RNAi-mediated knockdown of ATPalpha, Nervana 3, or any of 8 additional complex proteins enhanced seizure susceptibility. The critical period of Jus expression in epileptogenesis was further defined, occurring between pupal stages P4-7; remarkably, thejusseizure phenotype could be rescued by increasing neural activity ofjus-expressing neurons during these mid-pupal stages, suggesting that altered neural activity in these neurons may contribute to the seizure phenotype. Our data support a model that, in wild type flies, a protein complex containing Na+/K+ATPase and Jus prevents epileptogenesis, possibly by regulating neural activity.
Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids
Authors: Yang Xiao , Forró Csaba , Li Thomas L. , Miura Yuki , Zaluska Tomasz J. , Tsai Ching-Ting , Kanton Sabina , McQueen James P. , Chen Xiaoyu , Mollo Valentina , Santoro Francesca , Paşca Sergiu P. , Cui Bianxiao
Published: September 2023

Organoids and assembloids have emerged as a promising platform to model aspects of nervous system development. Longterm, minimally-invasive recordings in these multi-cellular systems are essential for developing disease models. Current technologies, such as patch-clamp, penetrating microelectrodes, planar electrode arrays and substrate-attached flexible electrodes, do not, however, allow chronic recording of organoids in suspension, which is necessary to preserve their architecture. Inspired by the art of kirigami, we developed flexible electronics that transition from a 2D pattern to a 3D basketlike configuration to accommodate the long-term culture of organoids in suspension. This platform, named kirigami electronics (KiriE), integrates with and enables chronic recording of cortical organoids while preserving morphology, cytoarchitecture, and cell composition. KiriE can be integrated with optogenetic and pharmacological stimulation and model disease. Moreover, KiriE can capture activity in cortico-striatal assembloids. Moving forward, KiriE could reveal disease phenotypes and activity patterns underlying the assembly of the nervous system.
Structural basis of transcription: RNA Polymerase II substrate binding and metal coordination at 3.0 Å using a free-electron laser
Authors: Lin Guowu , Barnes Christopher O. , Weiss Simon , Dutagaci Bercem , Qiu Chenxi , Feig Michael , Song Jihnu , Lyubimov Artem , Cohen Aina E. , Kaplan Craig D. , Calero Guillermo
Published: September 2023

Catalysis and translocation of multi-subunit DNA-directed RNA polymerases underlie all cellular mRNA synthesis. RNA polymerase II (Pol II) synthesizes eukaryotic pre-mRNAs from a DNA template strand buried in its active site. Structural details of catalysis at near atomic resolution and precise arrangement of key active site components have been elusive. Here we present the free electron laser (FEL) structure of a matched ATP-bound Pol II, revealing the full active site interaction network at the highest resolution to date, including the trigger loop (TL) in the closed conformation, bonafide occupancy of both site A and B Mg2+, and a putative third (site C) Mg2+analogous to that described for some DNA polymerases but not observed previously for cellular RNA polymerases. Molecular dynamics (MD) simulations of the structure indicate that the third Mg2+is coordinated and stabilized at its observed position. TL residues provide half of the substrate binding pocket while multiple TL/bridge helix (BH) interactions induce conformational changes that could propel translocation upon substrate hydrolysis. Consistent with TL/BH communication, a FEL structure and MD simulations of the hyperactive Rpb1 T834P bridge helix mutant reveals rearrangement of some active site interactions supporting potential plasticity in active site function and long-distance effects on both the width of the central channel and TL conformation, likely underlying its increased elongation rate at the expense of fidelity.
Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism
Authors: Perez Yonatan , Velmeshev Dmitry , Wang Li , White Matthew , Siebert Clara , Baltazar Jennifer , Dutton Natalia Garcia , Wang Shaohui , Haeussler Maximilian , Chamberlain Stormy , Kriegstein Arnold
Published: September 2023

Duplication 15q (dup15q) syndrome is the most common genetic cause of autism spectrum disorder (ASD). Due to a higher genetic and phenotypic homogeneity compared to idiopathic autism, dup15q syndrome provides a well-defined setting to investigate ASD mechanisms. Previous bulk gene expression studies identified shared molecular changes in ASD. However, how cell type specific changes compare across different autism subtypes and how they change during development is largely unknown. In this study, we used single cell and single nucleus mRNA sequencing of dup15q cortical organoids from patient iPSCs, as well as post-mortem patient brain samples. We find cell-type specific dysregulated programs that underlie dup15q pathogenesis, which we validate by spatial resolved transcriptomics using brain tissue samples. We find degraded identity and vulnerability of deep-layer neurons in fetal stage organoids and highlight increased molecular burden of postmortem upper-layer neurons implicated in synaptic signaling, a finding shared between idiopathic ASD and dup15q syndrome. Gene co-expression network analysis of organoid and postmortem excitatory neurons uncovers modules enriched with autism risk genes. Organoid developmental modules were involved in transcription regulation via chromatin remodeling, while postmortem modules were associated with synaptic transmission and plasticity. The findings reveal a shifting landscape of ASD cellular vulnerability during brain development.
Alcohol induces concentration-dependent transcriptomic changes in oligodendrocytes
Authors: Bazzi Sam A. , Maguire Cole , Mayfield R. Dayne , Melamed Esther
Published: September 2023

Oligodendrocytes are a key cell type within the central nervous system (CNS) that generate the myelin sheath covering axons, enabling fast propagation of neuronal signals. Alcohol consumption is known to affect oligodendrocytes and white matter in the CNS. However, most studies have focused on fetal alcohol spectrum disorder and severe alcohol use disorder. Additionally, the impact of alcohol dosage on oligodendrocytes has not been previously investigated. In this study, we evaluated transcriptomic changes in C57BL6/J cultured mature oligodendrocytes following exposure to moderate and high concentrations of alcohol. We found that high concentrations of alcohol elicited gene expression changes across a wide range of biological pathways, including myelination, protein translation, integrin signaling, cell cycle regulation, and inflammation. Further, our results demonstrate that transcriptomic changes are indeed dependent on alcohol concentration, with moderate and high concentrations of alcohol provoking distinct gene expression profiles. In conclusion, our study demonstrates that alcohol-induced transcriptomic changes in oligodendrocytes are concentration-dependent and may have critical downstream impacts on myelin production. Targeting alcohol-induced changes in cell cycle regulation, integrin signaling, inflammation, or protein translation regulation may uncover mechanisms for modulating myelin production or inhibition. Furthermore, gaining a deeper understanding of alcohol’s effects on oligodendrocyte demyelination and remyelination could help uncover therapeutic pathways that can be utilized independent of alcohol to aid in remyelinating drug design.
Analysis of output characteristics of wireless power transfer system based on LCC/S-S hybrid compensation structure
Authors: Wang Dangshu , Deng Xuan , Guan Zhimin , Liu Shulin , Yang Yaqiang , Wang Xinxia
Published: September 2023

Purpose

To simplify the circuit design and control complexity of the magnetic coupling resonant wireless charging system, the radio energy transmission constant current and constant voltage charging is realized.

Design/methodology/approach

The purpose of this study is to simplify the circuit design and control complexity of the magnetic coupling resonance wireless charging system, in order to achieve constant current and constant voltage charging for wireless energy transmission. First, the principle of LCC/S-S compensation structure is analyzed, and the equivalent mathematical model is established; then, the system characteristics under constant current and constant voltage mode are analyzed, and the design method of system parameters is given; finally, a simulation and experimental system is built to verify the correctness and feasibility of the theoretical analysis.

Findings

The results show that the proposed hybrid topology can achieve a constant current output of 2 A and a constant voltage output of 30 V under variable load conditions, and effectively suppress the current distortion problem under light load conditions. The waveform distortion rate of the inverter current is reduced from 33.97% to 10.45%.

Originality/value

By changing the high-order impedance characteristics of the compensation structure, the distortion of the current waveform under light load is suppressed, and the overall stability and efficiency of the system are improved.
Improved numerical integration for locking treatment in the Peridynamic Timoshenko beam model
Authors: Bai Ruqing , Naceur Hakim , Zhao Jinglei , Yi Jin , Ma Jie , Pu Huayan , Luo Jun
Published: September 2023

Purpose

In this paper, the standard Peridynamic Timoshenko beam model accounting for the shear deformation is chosen to describe the thick beam kinematics. Unfortunately, when applied to very thin beam structures, the standard Peridynamics (PD) encounters the shear locking phenomenon, leading to incorrect solutions.

Design/methodology/approach

PD differs from classical continuum mechanics and other nonlocal theories that do not involve spatial derivatives of the displacement field. PD is based on the integral equation instead of differential equations to handle discontinuities and other singularities.

Findings

The shear locking can be successfully alleviated using the developed selective integration method. In particular, this technique has been implemented in the standard PD, which allows an accurate result for a wide range of slenderness from very thin to thick (10 < L/t < 103) structures. It can also accelerate the computational time for particular dynamic problems using fewer neighboring integration particles. Several numerical examples are solved to demonstrate the effectiveness of the proposed method for modeling beam structures.

Originality/value

The paper highlights the severe shear locking phenomenon in the Peridynamic Timoshenko beam available in the literature, especially for very thin structures. A new alternative for the alleviation of shear locking in the Peridynamic Timoshenko beam, using selective integration. Hence the developed Peridynamic Timoshenko beam model is effective for thin and thick structures. A new peridynamic formulation for the low-velocity impact beam models is presented and validated.

Highlights

The paper highlights the severe shear locking phenomenon in the Peridynamic Timoshenko beam proposed in the literature, especially for very thin structures.

The developed Peridynamic Timoshenko beam model based on selective integration is effective for thin and thick structures.

A new peridynamic formulation for the low-velocity impact beam models is presented and validated.
The perceptions of diversity management and employee performance: UAE perspectives
Authors: Mahdi Abaker Mohamed Osman Shereif , Kemp Lindsey , Cho Boo Yun , Patterson Louise
Published: September 2023

Purpose

The purpose of this article was to investigate the employee perceptions of diversity management and employee performance. To achieve this, employee respondents’ perceptions and perspectives have been tested, and findings are discussed.

Design/methodology/approach

To address this study's purpose, survey data were collected from 250 employees of two organizations in the United Arab Emirates (UAE). Data were analyzed by age, gender and nationality for two variables: diversity management and employee performance.

Findings

Results showed that respondents perceived an improvement in employee performance when diversity was managed for employees of different age groups, females/males working together and a workplace composed of employees from various nationalities.

Research limitations/implications

The implication of this limited study is that further studies on the perception of diversity management for employee performance in the Middle East region needs to be conducted. The social implication is that organizational leaders can initiate diversity management to improve employee performance. The research is limited by the geographical context and access to the collection of data during the COVID-19 pandemic.

Social implications

The implication of this limited study is that further studies on the perception of diversity management for employee performance in the Middle East region needs to be conducted. The social implication is that organizational leaders can initiate diversity management to improve employee performance.

Originality/value

The contribution to academic knowledge from this research is two-fold: findings from a novel study conducted in the Middle East evidenced diversity management improved perceptions of employee performance. The value of the study for praxis is to incorporate employees' belief in diversity management for its potential to improve employee performance.
Pedagogical and socio-emotional impacts of COVID-19 on Guinean school children: evidence from a mixed cross-sectional study
Authors: Maltais Stéphanie , Bourgeois Isabelle , Moumouni Aissata Boubacar , Yaya Sanni , Doumbouya Mohamed Lamine , Béavogui Gaston , Mabeu Marie Christelle , Pongou Roland
Published: September 2023

Purpose

This study aims to determine the pedagogical and socio-emotional impacts of school closures caused by the COVID-19 pandemic in Guinea.

Design/methodology/approach

A descriptive, survey-based methodology was used to collect quantitative and qualitative data directly from parents and caregivers. Between February 24 and March 13, 2022, data was gathered from a study population comprising 2,955 adults residing in five communes and five prefectures of Guinea.

Findings

Half of all respondents stated that school closures had no particular impact on children in their household, and 42% stated that no intentional pedagogical activities took place during school closures. Approximately 15% of respondents stated that children experienced boredom, loneliness, sadness, depression, stress and anxiety during the school closures.

Originality/value

The study underscores the significance of school closure readiness and interactive learning while revealing limited emotional impact on children. The findings, while specific to Guinea, provide a foundational understanding, highlighting the complexity of pandemic effects on education and the need for adaptive strategies in vulnerable regions.
US road safety during COVID-19: motorist, pedestrian and bicyclist fatality trends
Authors: Ferenchak Nicholas N.
Published: September 2023

Purpose

The purpose of this paper is to illustrate how COVID-19 lockdowns in the USA impacted traffic safety.

Design/methodology/approach

The authors explored the role of vehicle, user and built environment factors on traffic fatalities in the USA, comparing results during COVID-19 lockdowns (March 19th through April 30th, 2020) to results for the same time period during the five preceding years. The authors accomplished this through proportional comparisons and negative binomial regression models.

Findings

While traffic levels were 30%–50% below normal during the COVID-19 lockdowns, all traffic fatalities decreased by 18.3%, pedestrian fatalities decreased by 19.0% and bicyclist fatalities increased by 3.6%. Fatal COVID-19 crashes were more likely single-vehicle crashes involving fixed objects or rollovers. COVID-19 traffic fatalities were most common on arterial roadways and in lower density suburban built environments. Findings suggest the importance of vulnerable road users, speed management and holistic built environment policy when pursuing safety on the streets.

Originality/value

The findings have road safety implications not only for future pandemics and other similar events where we would expect decreases in motor vehicle volumes (such as natural disasters and economic downturns) but also for cities that are pursuing mode shift away from personal automobiles and toward alternative modes of transportation.
Nature-related features and children’s well-being in post-disaster school design
Authors: Atmodiwirjo Paramita , Ghaziani Rokhshid , Wungpatcharapon Supreeya , Djuwita Ratna , Yatmo Yandi Andri
Published: September 2023

Purpose

This study aims to identify the role of nature-related features in promoting well-being from the perspective of children as the users of post-disaster schools. It highlights the importance of connectedness to nature in design strategies for post-disaster school reconstruction.

Design/methodology/approach

The mixed-method study was conducted in three primary schools reconstructed after the earthquakes in Lombok (Indonesia) and Chiang Rai (Thailand) that integrated some nature-related elements in their design. The questionnaire survey explored the children’s satisfaction with the post-disaster school environment as an indication of well-being.

Findings

The findings suggest that priority in post-disaster school design strategies should incorporate nature-related design features that provide opportunities for children to be with friends and to play, to learn in comfortable and safe conditions, to interact with nature and to be in a quiet and relaxing place.

Originality/value

Most post-disaster reconstruction prioritizes the speed of construction rather than the spatial qualities that could help children deal with the disaster. This study provides evidence on the potential of nature-related design features to support the children’s well-being after the disaster.
Working for a better future: exploring how network capital fosters Laotian migrant workers in Thai family SMEs
Authors: Daovisan Hanvedes , Charoenratana Sayamol , Akitsu Motoki
Published: September 2023

Purpose

Transnational migration is a key challenge in migrant-sending and host-receiving countries. However, relatively little is known about how migrants use network capital to foster small and medium-sized enterprises (SMEs) in the ASEAN Economic Community (AEC). Therefore, the purpose of this study is to explore how network capital fosters Laotian migrant workers in Thai family SMEs.

Design/methodology/approach

This research was conducted using qualitative network analysis (QNA). Referral snowball sampling was used to draw 20 participants from December 2021 to March 2022. Data analysis was performed using Gephi, a software package developed for QNA (coding, network features, measure nodes and network metrics).

Findings

The main findings are the following four emerging themes: chain networks, social networks, human networks and financial networks are associated with network capital for fostering Laotian migrant workers in Thai family SMEs.

Originality/value

To the best of the authors’ knowledge, this study is the first QNA to explore how Laotian migrant workers use network capital in Thai family SMEs.
Theory and analysis of disruptive deception: SME responses to B2B supply chain opportunism
Authors: Rynarzewska Ania Izabela , LeMay Stephen , McMahon Dave
Published: September 2023

Purpose

This study aims to examine small-firm shifts in behavior during major supply chain disruptions that change supply chains permanently. The study focuses on small to mid-sized enterprise (SME) responses to suppliers’ opportunistic behaviors within a larger disruptive environment. The study addresses two broad research questions: how do small businesses adapt to supply chain disruptions, and under what conditions are such adoptions warranted?

Design/methodology/approach

This study used mixed methods, a qualitative netnography and a quantitative analysis of survey data. It tested a model based on responses from members of an online business-to-business community. The model development was driven by the findings from netnography and two theoretical lenses.

Findings

The responses suggested a strong relationship between the two theoretical approaches. The conditions described by the resource-based view (RBV) of the firm led to many real options. Supply chain disruptions and deceptive suppliers triggered rapid adaptation through traditional marketing tactics and strategies. Changes in the supply chain, and place, led to responses in price, promotion and product. Respondents hoarded, developed relationships with new, nonopportunistic suppliers and changed prices, products and product mixes. They developed cooperative relationships – coopetition – to deal with shared problems.

Originality/value

This study interprets supply chain disruptions through the lens of marketing in SMEs; it combines qualitative and quantitative methods to better understand supply chain disruptions in a marketing context; it applies the real options theory and the RBV of the firm to marketing in the context of supply chain disruptions, and it reflects real-time small-firm behavior in a crisis.
Is ownership of brands passe? A new model of temporary usage for durable goods
Authors: Kerschbaumer René Hubert , Foscht Thomas , Eisingerich Andreas B.
Published: September 2023

Purpose

The trend toward subscription economy accelerated the rise of access-based consumption models for durable consumer goods, replacing individual ownership with subscription contracts. At the same time, disruptive platform businesses have arisen in several consumer markets, bypassing traditional value chains while growing through network effects. In a conceptual approach, the authors address the future market for durable consumer goods in light of developments toward access-based consumption, subscription models and platform business models.

Design/methodology/approach

In a conceptual approach, the authors apply a scenario analysis following the Framework Foresight method and address trends, constants, plans and projections shaping the future market of subscriptions for durable goods. The authors create a baseline scenario and two alternative scenarios for the future of consumer durables and thereby discuss platform growth stages and implications for manufacturer brands.

Findings

The rising market power of platform companies leads to a baseline scenario where these platforms enter the market of subscriptions for durable goods. Alternative scenario 1 addresses the successful market entry of new platform businesses. In contrast, alternative scenario 2 describes the rise of manufacturer brand platforms.

Originality/value

This conceptual research enriches the discussion of access-based business models by creating scenarios depicting possible future developments. Moreover, it adds to the increasing focus on platform business models and thereby addresses the role of traditional manufacturer brands in markets for durable consumer goods subscriptions.
Struggling with globalization challenges: addressing the oversupply of cultural facilities in the world heritage city of Cuenca, Ecuador
Authors: Sánchez Alvarado David , Arízaga Hamilton Nicolás , Heras Verónica Cristina , Rey-Pérez Julia
Published: September 2023

Purpose

Cuenca, a World Heritage City, faces urban expansion as residents move to the outskirts, leaving the historic center abandoned and deteriorating. The challenge now is to relocate these spaces into sustainable and cohesive nodes. This research aims to identify cultural facility oversupply in the city center and understand the required usage for heritage buildings to promote a habitable, sustainable and cohesive historic center.

Design/methodology/approach

The study consisted of two phases. Firstly, a georeferenced spatial analysis and monthly usage frequency of each facility is proposed. Secondly, interviews explored the criteria for designating heritage buildings as cultural facilities. Additionally, a survey assessed urban habitability in three historic center parishes, measuring aspects like coverage, satisfaction and security from residents' perspectives.

Findings

The underutilization of cultural facilities demonstrates both inefficient heritage management and a lack of resident interest in cultural activities and neighborhood decision-making. Thus, ensuring collective ownership of heritage assets becomes crucial. Additionally, the municipality's approach to heritage must be reconsidered. While implementing a cultural program may seem faster and cheaper, the long-term cost-benefit of maintaining a cohesive historical center outweighs that of a dispersed city.

Originality/value

This paper calls for a fundamental reimagining of the concept of built heritage, emphasizing the need for a more inclusive and integrated approach that goes beyond museum and tourism-driven strategies. This perspective recognizes the importance of social, cultural and environmental sustainability in revitalizing the historic center, considering the broader context of the city and its diverse inhabitants.
Servicescapes and social servicescapes: impact on perceived usefulness, choice satisfaction and behavior at fast-food restaurants
Authors: Asghar Awes , Asif Ruba , Akhtar Naeem
Published: September 2023

Purpose

The existing literature has examined the determinants of post-purchase behavioral intentions. However, less attention has been devoted to the factors that contribute to perceived usefulness of fast-food restaurants attributes. The current study considers the servicescapes and social servicescapes of restaurants as well as their relationship with customers' perceived usefulness, with the moderating role of customer experience. It also explores how perceived usefulness influences choice process satisfaction and subsequent behavioral responses, including revisit intention and negative word-of-mouth.

Design/methodology/approach

Data from 485 fast-food restaurant consumers in Pakistan were collected using purposive sampling. The data were analyzed using both structural equation modeling (SEM) through AMOS 24.0 and the PROCESS macro in IBM SPSS 27.0.

Findings

The research revealed that perceived usefulness in fast-food restaurant industry is positively influenced by servicescapes and social servicescapes. Similarly, choice process satisfaction is primarily caused by perceived usefulness and affects behavioral responses. It also found that choice process satisfaction is positively associated with revisit intentions and negative word-of-mouth. Customer experience significantly moderates the relationship between ambient condition, facility aesthetic, layout, perceived similarity and perceived usefulness. However, customer experience insignificant moderates the relationships of physical appearance and suitable behavior with perceived usefulness.

Research limitations/implications

The findings provide insightful information for both academic and managerial fields, contributing to the literature on consumer psychology, consumer behavior, servicescapes and the stimulus-organism-response theory. The study also assists restauranteurs in the fast-food restaurant industry in overcoming the challenges posed by a highly competitive environment and developing strategies based on consumer perceptions.

Originality/value

This study, conducted in Pakistan, took a pioneer step in testing and confirming a novel perceived usefulness model that incorporates not only servicescapes but also social servicescapes in consumer behavior. It enhances the knowledge of consumer visit intentions by quantifying the significance of perceived usefulness developed by different servicescapes.
Social media addiction and employee sleep: implications for performance and wellbeing in the hospitality industry
Authors: Wang Qian , Azam Sabahat , Murtza Muhammad Hamid , Shaikh Junaid M. , Rasheed Muhammad Imran
Published: September 2023

Purpose

This study is designed to investigate a critical association between social media addiction and employee sleep while considering its implications for employee well-being and performance in the hospitality industry.

Design/methodology/approach

Based on adapted measures for the study variables, an electronic questionnaire was designed and used for the survey administered in the chain-restaurants of Pakistan. Through a non-probability convenient sampling survey, a total of 347 usable responses were obtained and analyzed for testing the hypothesized research model.

Findings

Results reveal negative associations between social media addiction, sleep quality, employee performance and well-being. The results have further shown sleep quality as an underlying mediating reason that explains the associations between social media addiction, employee performance and well-being.

Originality/value

The study addresses a gap in the literature by examining rarely explored factors such as social media addiction and sleep quality at the same time investigating its impact on performance and well-being of service employees. Significant implications for scholars and practitioners of the hospitality industry have been discussed while highlighting limitations and directions for future research.
Sustainability-based enterprise supply chain optimization and response under circular economy approach: agile, adaptive and coordinated
Authors: Wu Yanhong , Wang Renlan
Published: September 2023

Purpose

From a supply chain perspective, logistics firms collaborate with other supply chain members to extend their business scope. Investment in circular economy projects in the supply chain can not only broaden the scope of business but also increase the value of the entire supply chain. Third-party logistics companies are gradually participating in the construction and operation of many circular economy projects. How to coordinate multiple circular economy supply chain projects is at the core of its operation.

Design/methodology/approach

This paper first analyzes some typical supply chain projects in China and summarizes the main features of these projects. Secondly, considering the benefits of the project and the stakes of each project, a multi-stage stochastic programming model is established. Finally, Cplex, nested decomposition, LocalSolver and other methods are adopted to simulate and analyze the model.

Findings

The final experimental results find that the importance of coordinating multiple circular economy supply chain projects to increase the value of the entire supply chain. The multi-stage stochastic programming model presented in this research can provide a useful tool for logistics enterprises and third-party logistics companies to optimize their investment decisions and maximize their profits in the context of a circular economy.

Research limitations/implications

There are still some limitations to this study; for example, it is limited to the analysis of circular economy supply chain projects in China. The study focused on third-party logistics companies, and other enterprises in the circular economy supply chain were not considered. The research also assumed that the benefits of each circular economy project and the stakes of each project were known, which may not always be the case in real-world scenarios.

Originality/value

This manuscript found that investing in other circular economy projects in the supply chain can broaden the scope of business and increase the value of the entire supply chain. Third-party logistics companies are gradually participating in the construction and operation of many circular economy projects, such as recycling and repurposing initiatives. It highlights the importance of coordinating multiple circular economy supply chain projects to increase the value of the entire supply chain. The multi-stage stochastic programming model presented in this research can provide a useful tool for logistics enterprises and third-party logistics companies to optimize their investment decisions and maximize their profits in the context of a circular economy.
The human side of entrepreneurship: an empirical investigation of relationally embedded ties with stakeholders
Authors: Cucino Valentina , Marullo Cristina , Annunziata Eleonora , Piccaluga Andrea
Published: September 2023

Purpose

Humane Entrepreneurship (HumEnt) is strongly purpose-oriented and characterized by a focus on inclusiveness and social and environmental sustainability, with attention to both internal and external stakeholders and their needs. In the attempt to provide new research in this field, this study aims to conduct an empirical investigation within the theory of HumEnt and, in particular, of the Human Resource Orientation (HRO) model among Italian Small and Medium-size Enterprises.

Design/methodology/approach

Based on quantitative data, this study used a deductive approach to investigate the relationship between the HumEnt model and firms’ relational embeddedness with different types of stakeholders (value chain stakeholders and societal stakeholders, respectively). More concretely, to investigate the relationships between the dimensions of the HumEnt model and firms’ relational embeddedness, partial least squares structural equation modeling was applied.

Findings

Findings of this study suggest that Entrepreneurial Orientation (EO) directly contributes only to value chain embeddedness. However, the results also show that if EO is mediated by an HRO (i.e. companies with a high HRO), a high level of societal embeddedness is also present.

Originality/value

This study represents a first attempt to provide comprehensive empirical evidence about the different dimensions characterizing the HumEnt theoretical model, and to highlight their relevance in supporting companies’ relational embeddedness capacity with different categories of stakeholders.
Minimum dietary diversity and the concurrence of stunting and overweight among infants and young children in Yogyakarta, Indonesia
Authors: Paramashanti Bunga Astria , Paratmanitya Yhona , Kusumaningtyas Ignasia Ika , Khasana Tri Mei , Yugistyowati Anafrin , Siswati Tri
Published: September 2023

Purpose

This study aims to examine the association between minimum dietary diversity (MDD) and the concurrence of stunting and overweight (CSO) among children aged 6–23 months.

Design/methodology/approach

A cross-sectional study was conducted in Sedayu Subdistrict, Bantul District, Daerah Istimewa Yogyakarta. The authors assessed the concurrence of stunting (height-for-age Z-score below −2 standard deviations SD) and overweight/obesity (Body mass index BMI-for-age Z-score above +2 SD) among a total of 189 children aged 6–23 months as the primary outcome. The authors defined MDD as consuming at least four out of seven food groups using a single 24-h recall. The authors also included other covariates, including sociodemographic characteristics, exclusive breastfeeding history and complementary feeding practices. To identify the factors associated with CSO, this study conducted multiple logistic regression across the study variables using STATA 16.1.

Findings

In the adjusted model, children who met the MDD criterion were associated with a reduced risk of CSO (adjusted odds ratios [OR]: 0.14; 95%confidence interval CI: 0.03–2.43). Compared to boys, girls were more likely to experience CSO (adjusted OR: 5.23; 95%CI: 1.02–26.9). Middle economic status was a protective factor for CSO (adjusted OR: 0.10; 95%CI: 0.01–0.98). This study did not find a significant relationship between CSO and the child’s age, low birth weight, exclusive breastfeeding, energy intake, protein intake, parental education and parental occupation.

Practical implications

This study suggests future programs and policies that promote dietary diversity to reduce the risk of CSO.

Originality/value

This study reveals the association between MDD and the coexistence of stunting and overweight.
Effect of non-nutritive sweeteners on insulin regulation, glycemic response, appetite and weight management: a systematic review
Authors: Mathur Pulkit , Bakshi Anjani
Published: September 2023

Purpose

The purpose of this study is to collect and assess the evidence available on the effect of non nutritive sweeteners on appetite, weight and glycemic regulation. As a replacement for sugars, non-nutritive sweeteners (NNSs) are widely being used in different food products with the assumption that these would lower calorie intake and help to manage weight and blood sugar levels better. However, studies using animal models have reported that chronic exposure to NNSs leads to increased food consumption, weight gain and insulin resistance.

Design/methodology/approach

Evidence was acquired from systematic reviews or meta-analyses (2016–2021) of relevant clinical studies, especially randomized control trials using Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.

Findings

The review showed NNSs exposure did not conclusively induce increased food intake or change in subjective appetite ratings. Appetite biomarkers like ghrelin, gastric inhibitory peptide, C-peptide levels and Peptide YY remained mostly unaffected by NNSs. Meta-analyses of human randomized control studies showed a reduced energy intake and body weight. No significant change was seen in blood glucose levels, post-prandial glycemic or insulin response after consumption of NNSs. Adequate evidence is not available to conclusively say that NNSs influence gut health at doses relevant to human use.

Research limitations/implications

Most studies which are prospective cohort, observational and cross-sectional studies suggest that use of NNSs may promote obesity and metabolic syndrome in adults. Such studies are plagued by confounding variables and reverse causation. Mechanistic evidence is mostly based on in-vitro and in-vivo studies. The same causal pathways may not be operative or relevant in humans.

Practical implications

This review of available literature concludes that to achieve specific public health and clinical goals, the safe use of NNSs for the reduction of intakes of free sugars and energy should be explored. This would be possible by educating the consumer about energy compensation and understanding the nutritional content of artificially sweetened products in terms of calories coming from fat and complex carbohydrates used in the product.

Originality/value

This study was, thus, designed with the objective of examining the usefulness of NNSs in human population, especially with respect to insulin regulation, glycemic control and weight management. Well-designed randomized control trials which control for confounding variables are needed to generate high quality evidence.
Understanding Shadow IT usage intention: a view of the dual-factor model
Authors: Nguyen Trang
Published: September 2023

Purpose

Despite the growing concern about security breaches and risks emerging from Shadow IT usage, a type of information security violation committed by organizational insiders, this phenomenon has received little scholarly attention. By integrating the dual-factor theory, unified theory of acceptance and use of technology (UTAUT) and social control theory, this research aims to examine facilitating and deterring factors of Shadow IT usage intention.

Design/methodology/approach

An online survey was performed to obtain data. As this study aims at investigating the behavior of organizational insiders, LinkedIn, an employment-oriented network site, was chosen as the main site to reach the potential respondents.

Findings

The results show that while performance expectancy, effort expectancy and subjective norms considerably impact intention to use Shadow IT, personal norms and sanctions-related factors exert no influence. Besides, an organizational factor of ethical work climate is found to significantly increase individual perceptions of informal controls and formal controls.

Originality/value

This work is the first attempt to extend the generalizability of the dual-factor theory and UTAUT model, which primarily has been utilized in the context of system usage, to the new context of information security. This study is also one of few studies that simultaneously take both organizational and individual factors into consideration and identify its impacts on user's behaviors in the information security context.
Analysis of additively manufactured flexible wing model
Authors: Fernandes Rossana , Hu Benyang , Wang Zhichao , Zhang Zheng , Tamijani Ali Y.
Published: September 2023

Purpose

This paper aims to assess the feasibility of additively manufactured wind tunnel models. The additively manufactured model was used to validate a computational framework allowing the evaluation of the performance of five wing models.

Design/methodology/approach

An optimized fighter wing was additively manufactured and tested in a low-speed wind tunnel to obtain the aerodynamic coefficients and deflections at different speeds and angles of attack. The flexible wing model with optimized curvilinear spars and ribs was used to validate a finite element framework that was used to study the aeroelastic performance of five wing models. As a computationally efficient optimization method, homogenization-based topology optimization was used to generate four different lattice internal structures for the wing in this study. The efficiency of the spline-based optimization used for the spar-rib model and the lattice-based optimization used for the other four wings were compared.

Findings

The aerodynamic loads and displacements obtained experimentally and computationally were in good agreement, proving that additive manufacture can be used to create complex accurate models. The study also shows the efficiency of the homogenization-based topology optimization framework in generating designs with superior stiffness.

Originality/value

To the best of the authors’ knowledge, this is the first time a wing model with curvilinear spars and ribs was additively manufactured as a single piece and tested in a wind tunnel. This research also demonstrates the efficiency of homogenization-based topology optimization in generating enhanced models of different complexity.