bluuebunny/crossref_metadata_2025 huggingface dataset:
CONTRIBUTION OF mTORC1 AND GSK-3 TO THE REGULATION OF RIBOSOME BIOGENESIS IN RAT POSTURAL MUSCLE UNDER SIMULATED MICROGRAVITY
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Rozhkov S.V. , Sharlo K.A. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Shenkman B.S. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Mirzoev Т.М. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: September 2022

The investigation was aimed to reveal a potential role of mechanistic target of rapamycin (mTORC1) and glycogen synthase kinase (GSK-3) in the regulation of ribosome biogenesis and protein synthesis in rat soleus muscle during simulated gravitational unloading. Wistar rats were subject to 7-day tail-suspension (hindlimb unloading) and treated with rapamycin (mTORC1 inhibitor) or AR-A014418 (GSK-3 inhibitor). Protein synthesis was measured with SUnSET. Phosphorylation of glycogen synthase-1 (GS-1) and ribosomal protein S6 (rpS6) was measured with the use of Western-blotting. Levels of 28S and 18S rRNA were determined using agarose gel electrophoresis. Expression of 47S pre-rRNA and c-Myc was assessed with RT-PCR. Gravitational unloading led to an increase in phosphorylation of GS-1 (a marker of GSK-3 activity) and inhibited phosphorylation of rpS6 (a marker of mTORC1 activity), expression of the ribosome biogenesis markers (total RNA РНК, 28S and 18S rRNA, 47S pre-rRNA, с-Myc) and protein synthesis in soleus muscle. GSK-3 inhibition prevented an increase in GS-1 phosphorylation and, partly, a reduction in the markers of both ribosomal biogenesis and protein synthesis. The mTORC1 inhibitor contributed to the phospho-rpS6 reduction but did not substantially influence the parameters of translational capacity and protein synthesis. To sum up, unlike mTORC1, an elevated GSK-3 activity can contribute to the inhibition of ribosome biogenesis and protein synthesis in rat soleus muscle under 7-day gravitational unloading.
DYNAMICS OF THE BRAIN POTENTIALS IN VOLUNTEERS FOR MODELED HEAD-TO-PELVIS G-LOADS (+GZ) ON A SHORT-ARM HUMAN CENTRIFUGE
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Schastlivtseva D.V. , Kotrovskaya T.I. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Koloteva M.I. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Glebova Т.М. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: September 2022

A series of +Gz runs on a short-arm human centrifuge (SAHC) was performed in support of the proposal to design a centrifuge as a source of gravity aboard piloted exploration vehicles. Nine male volunteers participated in a 3-stage experiment with exposure to 2.1 g, 2.41 g and 2.92 g. The runs were accompanied by electroencephalography monitoring (EEG). Classic visual EEG analysis revealed characteristic and individual changes in the brain bioelectrical activity. Spectral analysis provided information about relative powers (RP) of the EEG bands: delta-2 (2–4 Hz), tetha (4–8 Hz), alpha (8–13 Hz) and beta-1 (13–24 Hz) in 19 leads total. The body of RP changes made it possible to trace dynamics of the brain functional response to different g-loads. The greatest tetha RP decay (up to 15.5 %) with the simultaneous beta RP rise up to 8.4 % at 2.92 g pointed to activation of the cortex of cerebral hemispheres due to attenuation of the inhibitory effect of the nonspecific brain system. The neurophysiological individual typological patterns and absence of alpha RP changes implied a reasonably good CNS adaptation to all SAHC g-loads.
Targeting Glutaminolysis to Treat Multiple Myeloma: An In Vitro Evaluation of Glutaminase
Inhibitors Telaglenastat and Epigallocatechin-3-gallate
Authors: Feng Yuhu , Li Chen , Wang Weiguo , Xu Lingyun , Zhang Miao , Yao Yue , Wu Xiaoqian , Zhang Qin , Huang Wenyue , Wang Xiuxiu , Li Xue , Ying Peipei , Shang Liu
Published: September 2022

Background:

Cancer is associated with metabolic changes from increased cell proliferation and growth.
Compared to normal differentiated cells, MM cells use the glycolytic pathway even when adequate oxygen is present
triggering “Glutamine addiction”.

Objective:

To investigate the single and combined effects of epigallocatechin-3-gallate (EGCG) and telaglenastat, a
glutaminase inhibitor, on the proliferation and apoptosis of the multiple myeloma cell line KM3/BTZ.

Methods:

KM3/BTZ cells were treated with different concentrations of telaglenastat and EGCG alone or in combination
to investigate their effect on proliferation and apoptosis using the CCK8 assay, flow cytometry, and western blotting.
The Chou-Talalay combination index analysis was used to explore the effect of telaglenastat combined with
EGCG, while the Combination Index (CI) was calculated to analyze whether the combination of the two drugs had a
synergistic effect.

Results:

Telaglenastat and EGCG alone as well as in combination (5 μmol/L telaglenastat + 120 μmol/L EGCG) significantly
inhibited the proliferation of KM3/BTZ cells compared to the inhibition effect of the control. Additionally,
the combined treatment increased the proportion of KM3/BTZ cells in the G2 phase and decreased the proportion of
cells in the G1 phase. The apoptosis rate of EGCG alone and the combined treatment was significantly higher than that
of the control group. Bax protein expression was highest in the combined treatment group, whereas Bcl-2 expression
was lowest, with the combined treatment group having the highest ratio of Bax/Bcl-2.

Conclusion:

Telaglenastat and EGCG act synergistically to inhibit cell proliferation and promote apoptosis in
KM3/BTZ cells, possibly by targeting glutamine metabolism and glycolysis.
Advanced Membrane Processes for the Removal of Emerging Water Pollutants
Authors: Tufail Arbab
Published: September 2022

This chapter demonstrates the source and pathway of emerging
contaminants (ECs) and their removal by advanced membrane technologies. These ECs
are naturally occurring or synthetic organic pollutants, including pharmaceuticals and
personal care products, estrogens, industrial chemicals, UV filters, pesticides, and
endocrine-disrupting chemicals ubiquitously detected in wastewater and wastewater impacted surface waterbodies. Emerging contaminants have detrimental effects on
aquatic flora and fauna and may affect human health. Due to the persistent nature of
ECs, they are resistant to conventional wastewater treatments. Moreover, different
physicochemical processes have shown ineffectiveness for the removal of ECs.
Therefore, there is a need for robust wastewater treatment processes such as advanced
membrane technologies that can effectively remove these ECs. Advanced membrane
technologies use membranes that separate ECs from the solution and include forward
osmosis, reverse osmosis, nanofiltration, ultrafiltration, microfiltration, catalytic
membranes, and membrane bioreactors. Briefly, the focus of this chapter is to provide
an overview of different membrane separation technologies and illustrate various
examples of ECs removal.
Integrated Processes for Removal of Emerging Water Pollutants
Authors: Saud Baig Muhammad , Ahmed Siraj , Mujtaba Ghulam , Rizwan Muhammad , Ahmed Naveed , Ahmed Sheeraz
Published: September 2022

As the world advances rapidly in technology, industries are experiencing
rampant growth, and the healthcare sector is reaching new heights; however, novel
challenges are emerging that threaten humanity in entirely new ways. Industrial
development, large-scale urbanization, and hazardous effluent from healthcare facilities
increase concentrations of emerging pollutants in our surface waters. Emerging
pollutants have puzzled the researchers as they are relatively in smaller quantities than
other pollutants, yet they pass through the conventional water treatment processes
unscathed. Innovative integrated methods must be employed to enhance the water
quality by significantly removing these persistent emerging pollutants. This chapter
dives deeper into modern research to remove emerging water pollutants effectively.
Integrated methods such as integrated electrocoagulation, activated sludge with
membrane technology, and construction of wetlands are thoroughly presented. 
FAMILIA ARISTOLOCHIACEAE
Authors:   Facultad de Biología, Universidad Michoacana de San Nicolás de Hidalgo, Paizanni Guillén Anna , Santana Michel Francisco Javier
Published: September 2022

La familia Aristolochiaceae en los últimos siglos ha pasado por diferentes cambios en su clasificación. Forma parte del orden Piperales, que consiste por un lado de Aristolochiaceae, Asaraceae, Lactoridaceae e Hydnoraceae, que se caracterizan por presentar perianto y por otro lado las Piperaceae y Saururaceae sin perianto. Actualmente comprende dos géneros: Aristolochia L., con alrededor de 500 especies de distribución pantropical y Thottea Rottb., con 35 especies habitantes de Asia. El género Aristolochia es el más extenso de la familia y el único representado en México.
FAMILIA COMPOSITAE TRIBU GOCHNATIEAE
Authors:   Department of Natural Sciences, Northwest Missouri State University, Cabrera R. Leticia , Rzedowski Jerzy ,   Instituto de Ecología, A.C., Centro Regional del Bajío
Published: September 2022

En el actual estado de conocimiento la tribu consiste de cinco géneros: Cnicothamnus, Cyclolepis, Richterago, Gochnatia y Nahuatlea, éste último incluye todas las especies mexicanas. En nuestra región de estudio, solo existe el género Nahuatlea.
FAMILIA COMPOSITAE TRIBU INULEAE
Authors:   Instituto de Ecología, A. C., Centro Regional del Bajío, Redonda-Martínez Rosario
Published: September 2022

La tribu Inuleae incluye 62 géneros y alrededor de 700 especies a nivel mundial; en México se conocen 4 géneros y 12 especies. Para el área de estudio, se registran dos géneros, tres especies y dos categorías infraespecíficas.
FAMILIA LEGUMINOSAE, SUBFAMILIA PAPILIONOIDEAE: (Aeschynomene - Diphysa)
Authors:   Instituto de Ecología, A. C., Centro Regional del Bajío, Rzedowski Jerzy , Calderón de Rzedowski Graciela ,   Instituto de Ecología, A.C., Centro Regional del Bajío, Torres Colín Leticia ,   Instituto de Biología, Universidad Nacional Autónoma de México, Grether Rosaura ,   Departamento de Biología, División de CBS, Universidad Autónoma Metropolitana-Iztapalapa
Published: September 2022

La subfamilia es de distribución cosmopolita y está representada por cerca de 500 géneros y poco menos de 14,000 especies, que habitan en todo tipo de ambientes. Incluye una gran cantidad de plantas útiles para el hombre, entre las alimenticias, forrajeras, maderables, ornamentales, medicinales, así como de numerosos usos más
Breeding of the herbifagic insect Tarachidia candefacta Hubn. on an artificial nutrient medium to suppress the development of Ambrosia artemisiifolia L plants
Authors: Agasieva Irina S. , Nastasiy Anton S. , Nefedova Mariya V.
Published: September 2022

Ragweed (Ambrosia artemisiifolia L.) is an invasive plant species from the American continent, which has actively penetrated plant communities, displacing local species of cultivated and weed vegetation. The uncontrolled development and widespread distribution of ragweed in the South of Russia are associated with the absence of natural enemies of this weed. Ragweed is not only a competitor of cultivated and weed plants but also causes allergic diseases. The ragweed moth (Tarachidia candefacta Hbn.) was imported from Canada as a biological agent to control ragweed's development and distribution. We used the mass release of herbiphage into agrocenoses during the emergence of ragweed, which implies an artificial shift in the phenophase of the bioagent, which was achieved by early mass dilution on an artificial nutrient medium (ANM) under laboratory conditions. To cultivate the ragweed moth, the ANM was improved by adding powdered milk as a source of protein and vitamins to the composition, which made it possible to improve the quality of the environment and improve the biological indicators of the development of the bioagent. Replacement of wheat germ with soybean meal in ANM made it possible to obtain a feed balanced in protein and amino acid composition for growing herbiphage. As a result of the research, a method of colonization of the ragweed moth was developed, based on the early mass cultivation of herbiphage on an improved formulation of ANM and the release of T. candefacta at the beginning of the growing season of the weed, which allowed to suppress its growth by half.
Síndrome de Brooke-Spiegler: una infrecuente enfermedad a tener en cuenta en la práctica dermatológica.
Authors: Letona-García Nimzy J.Z. , Vasquez-Bonilla Walter O. , Medina Pebbles , Porres-Paredes Héctor Salvador , Muñoz-Lara Fausto
Published: September 2022

El síndrome de Brooke-Spiegler (SBS) es una enfermedad autosómica dominante infrecuente, los pacientes con el SBS presentan mutaciones en el gen supresor tumoral CYLD, más frecuente en mujeres que hombres, entre la segunda y tercera década de la vida con una relación hombre:mujer de 1:6-9.6 y su incidencia exacta se desconoce. Clínicamente se presentan de manera simultánea cilindroma, tricoepiteliomas y espiroadenomas. Se presenta el caso de una paciente femenina de 64 años, quien consultó por aparición de masas en cabeza, tronco y las cuatro extremidades de 10 años de evolución, posteriormente aparecieron lesiones en cuero cabelludo, donde el crecimiento tuvo una evolución más lenta y que llegaron a ulcerarse; busca atención medica hasta que las lesiones iniciaron a ulcerarse, por lo cual fue referida al Hospital General San Juan de Dios de la Ciudad de Guatemala, al servicio de dermatología, donde se le realizó hematología completa, química sanguínea, tomografía computarizada de cráneo y biopsia incisional en sacabocados de 4 mm de piel de frente, mentón, región preauricular derecha y pierna derecha, el estudio histopatológico de las lesiones cutáneas en las regiones preauricular derecha y de frente reporto cilindroma, piel de mentón tricoepitelioma y piel de pierna derecha espiroadenoma. Con los hallazgos clínicos, estudios de imagen y hallazgos histopatológico se llega al diagnóstico de síndrome de Brooke-Spiegler. El tratamiento fue la prescripción cuidados de piel y derivación a cirugía plástica para tratamiento quirúrgico reconstructivo y seguimiento por la consulta externa de dermatología y cirugía plástica. La presencia de cilindromas, tricoepiteliomas y espiroadenomas hacen pensar en un síndrome de Brooke-Spiegler, que tienden a tener presentaciones muy sugestivas, como el tumor en turbante y desfiguración de la región de la cabeza. El abordaje es multidisciplinario, sin un tratamiento definitivo y seguimiento para evaluar las posibles conversiones a malignidad de las lesiones ulceradas.

Palabras claves: Cilindroma, CYLD, Espiroadenoma, Histopatología.
Understanding the Influence of Web-Based Information, Misinformation, Disinformation, and Reinformation on COVID-19 Vaccine Acceptance: Protocol for a Multicomponent Study
Authors: Dubé Eve , MacDonald Shannon E , Manca Terra , Bettinger Julie A , Driedger S Michelle , Graham Janice , Greyson Devon , MacDonald Noni E , Meyer Samantha , Roch Geneviève , Vivion Maryline , Aylsworth Laura , Witteman Holly O , Gélinas-Gascon Félix , Marques Sathler Guimaraes Lucas , Hakim Hina , Gagnon Dominique , Béchard Benoît , Gramaccia Julie A , Khoury Richard , Tremblay Sébastien
Published: September 2022

Background

The COVID-19 pandemic has generated an explosion in the amount of information shared on the internet, including false and misleading information on SARS-CoV-2 and recommended protective behaviors. Prior to the pandemic, web-based misinformation and disinformation were already identified as having an impact on people’s decision to refuse or delay recommended vaccination for themselves or their children.

Objective

The overall aims of our study are to better understand the influence of web-based misinformation and disinformation on COVID-19 vaccine decisions and investigate potential solutions to reduce the impact of web-based misinformation and disinformation about vaccines.

Methods

Based on different research approaches, the study will involve (1) the use of artificial intelligence techniques, (2) a web-based survey, (3) interviews, and (4) a scoping review and an environmental scan of the literature.

Results

As of September 1, 2022, data collection has been completed for all objectives. The analysis is being conducted, and results should be disseminated in the upcoming months.

Conclusions

The findings from this study will help with understanding the underlying determinants of vaccine hesitancy among Canadian individuals and identifying effective, tailored interventions to improve vaccine acceptance among them.

International Registered Report Identifier (IRRID)

DERR1-10.2196/41012
Impact of COVID-19 on road trauma in Vietnam: a positive side of the pandemic. (Preprint)
Authors: Nguyen Ba Tuan , Blizzard Christopher Leigh , Palmer Andrew , Nguyen Huu Tu , Cong Quyet Thang , Tran Viet , Nelson Mark
Published: September 2022

BACKGROUND

Road trauma remains a significant contributor to mortality in Vietnam despite significant improvement in the last decade. The COVID-19 pandemic necessitated public health measures such as social distancing and lockdowns, which had an unforeseen benefit on road trauma in high income countries. This article aims to investigate if those reductions were also seen in Vietnam, a low to middle income country.

OBJECTIVE

Our aims to investigate how COVID-19 pandemic happen in Vietnam, the government policies again this deadly disease and it effect on road trauma fatalities

METHODS

We used published data from the Vietnamese Ministry of Health (MoH) for COVID-19 data and the Vietnamese General Statistic Office (GSO), traffic police department for the last 15 years (from 2007 to 2021) for road traffic mortality. Poisson regression modelling was used to estimate trends in annual national road fatality rates for the period 2007–2021. The actual road traffic mortality in 2021 was compared with projected figures to demonstrate the effect of COVID-19 on road trauma deaths.

RESULTS

Between 2007 and 2020 the number of annual road traffic deaths had more than halved from 15.3 to 7.0 per 100,000, an average reduction of 5.4% per annum. We estimated that this reduction would increase to 12.1% (95% CI 8.9%, 15.3%) in 2021 if current trends persisted. The actual number of road trauma deaths fell by 16.4%. On a monthly scale, this reduction was largely seen from August to October when lockdown and social distancing was in force. It can reasonably be concluded that government policies to address the COVID-19 pandemic resulted in an additional 4.3% decrease of road traffic deaths in 2021.

CONCLUSIONS

In 2021the road traffic death reduction in Vietnam was 3 time greater than the trend over the preceding 14 years. The public heath response to the COVID-19 pandemic in Vietnam was associated with a third of this reduction. This has been observed in High-Income Countries but was demonstrated by us for the first time in a Low- and Middle-Income Country.
Effects of customized digital healthcare service on metabolic syndrome status and lifestyle: Clinical trial using a healthcare application (Preprint)
Authors: Bae Chul-young , Kim Bo-seon , Cho Kyung-hee , Kim Ji-hyun , Kim In-hee , Kim Jeong-hoon
Published: September 2022

BACKGROUND

Untact cultures have rapidly spread around the world as a result of the prolongation of the COVID-19 pandemic, leading to various types of research and technological developments in the fields of medicine and healthcare, where digital healthcare refers to healthcare services provided in a digital environment.

OBJECTIVE

This study aimed to identify the effects of using a customized digital healthcare service (CDHCS) on risk factors for metabolic syndrome (MS) and lifestyle improvement.

METHODS

The population consisted of 63 adults who underwent a health checkup at the National Health Insurance Service Ilsan Hospital in 2020. Measured variables include basic clinical indicators, MS-related variables, and lifestyle variables. The CDHCS used in this study is a mobile application that analyzes the health condition of the user by identifying their risk factors and provides appropriate healthcare content.

RESULTS

All measured variables, except drinking status, showed a tendency towards improvement, but the differences were not statistically significant.

CONCLUSIONS

Although there was no statistical significance in the variables under study, this pilot study will provide a foundation for more accurate verification of CDHCS in future research.

CLINICALTRIAL

All participants received verbal explanations regarding the study and submitted their prior written consent. This study was approved by the Institutional Review Board (IRB) of NHIS Ilsan Hospital (NHIMC 2020-02-002).
Utilization of Biochar as organic fertilizer for Seedling growth of Zea mays (Maize)
Authors: Juliet Opara Ifeoma , Oziri Ukoha Pius , Lawrence Obasi Nnamdi , Nwachukwu Ekere
Published: September 2022

The seedling growth of maize, their germination rate and seedling length were ascertained using biochar pyrolyzed at temperatures between 400-550oC. All the biochar used were alkaline and contained mineral-rich components such as; C, Ca, O, K, Na, Mg, Si, Al, that could enrich the soil and as well treat acidic soil. Also all the biochar produced are good for planting. However, biochar pyrolyzed at 400oC gave the maximum seedling growth length. The germination rate was between 75%-100%. Biochar produced at 400o C was significantly (P <1.000) greater than SDB450. There is no significant difference between SDB450 and SDB500 (P < .461), also no significant difference between SDB 550 and control (P < .192 at a 95% level of significance. Biochar utilization could be a promising way of reducing the negative environmental effect of fertilizer.
Impact of comparative effectiveness research on Medicare coverage of direct oral anticoagulants
Authors: Arora Prachi , Muehrcke Maria , Russell Molly , Jayasekare Rasitha
Published: September 2022

Aim:To evaluate the association of comparative effectiveness research with Medicare coverage of direct oral anticoagulants.Materials & methods:A literature review for direct oral anticoagulants was conducted from 2011 to 2017. Monthly prescription drug plan and formulary files (n = 28) were used to conduct change-point analysis and assess each outcome variable.Results:Up to 2013, studies showed that dabigatran was more effective than rivaroxaban. In 2015, apixaban was shown to be the safest and most effective drug in comparison with all direct oral anticoagulants. In 2016–2017, dabigatran and apixaban were shown to have similar efficacy. Approximately 75% of plans covered dabigatran under tier 3 until 2015. From 2011 to 2017, less than 30% of plans required prior authorizations, 50% imposed quantity limits and mean copayment was lowest for rivaroxaban.Conclusion:Consistent with comparative effectiveness research, Medicare plans covered apixaban more favorably and edoxaban less favorably. However, discrepancies in comparative effectiveness research translation were found for rivaroxaban and dabigatran.
ENTRE LA PRECARIZACIÓN DE LOS DERECHOS Y LA PRODUCCIÓN DE SUBJETIVIDAD POLÍTICA EN EXPERIENCIAS DE JÓVENES TRANS EN MÉXICO
Authors: Zamorano Martínez Lenin Adolfo , Lozano-Verduzco Ignacio , Mendoza-Pérez Juan Carlos , Eaton Andrew , Craig Shelley
Published: September 2022

El objetivo de esta investigación cualitativa fue comprender cómo operan las diferentes prácticas y los discursos que atentan contra la dignidad e integridad de jóvenes trans. Se realizaron grupos focales y entrevistas semiestructuradas a 23 jóvenes trans entre 16 y 29 años en México. A través de un análisis de contenido, se identificaron las prácticas y discursos desde los cuales se atentó contra sus derechos en diferentes dimensiones (identitaria, laboral, educativa, de salud, espacial). Además, se identificaron los actos y recursos que ejercieron para hacer frente a las diversas formas de vulneración, tales como las emociones, las tecnologías de información y comunicación, y el arte. Concluimos que las relaciones de desigualdad social se traducen en precarización de los derechos humanos y, al mismo tiempo, en la base que contribuye a resistir la precarización de los derechos y a la construcción de una subjetividad política trans.
FENOMENOLOGÍA PARA LA SUBVERSIÓN DE LA RAZÓN MODERNA PATRIARCAL, COLONIAL Y ANTROPOCÉNTRICA
Authors: Calvo Rivera Érika
Published: September 2022

Este artículo fue pensado con el objetivo de desentrañar el fundamento patriarcal, colonial y antropocéntrico subyacente a dos de los mitos constitutivos de la razón moderna: la posibilidad de un conocimiento desencarnado y el dualismo sujeto-objeto. Se argumenta, en sintonía con la propuesta fenomenológica, que la experiencia del cuerpo vivido es el “punto cero” de nuestro estar en el mundo y, por ende, la condición de posibilidad de todo constructo epistemológico. La pretensión moderna de elevarse a una universalidad desprovista de toda subjetividad y condicionamiento espacio-temporal es, por tanto, nada más que un delirio encubridor de la experiencia en primera persona de un sujeto concreto: el varón blanco y occidental. Se apuesta así por caminar hacia una racionalidad ampliada que, desde la experiencia corporal y geopolítica, permita subvertir la situación de subalternidad en la que habitan tres cuartas partes de los habitantes del planeta.
Sermones y relaciones de fiestas: aspectos editoriales y manejo de las circunstancias (el Sagrado padrón, de Alonso Ramírez de Vargas)
Authors: Castaño Ana
Published: September 2022

Revisión de la historia editorial del Sagrado padrón, relación de los festejos realizados en la capital novohispana en 1690 por la dedicación del Templo de San Bernardo, escrita por Alonso Ramírez de Vargas, que incluye nueve sermones y una elegía en verso. Se informa sobre la existencia de dos diferentes emisiones de la obra, hasta ahora desconocidas por la crítica y los bibliógrafos, así como de dos ediciones de la misma. Dicha historia ilustra el vínculo editorial y literario que existió en la Nueva España del siglo XVII entre los sermones y las relaciones de las fiestas durante las cuales se predicaron, vínculo que también se refleja en los textos y paratextos de esos sermones y de las relaciones que los enmarcan.
Determination of procedural pain intensity among Critically-Ill patients: Using Behavioral Pain Scale (BPS)
Authors: Emad Bachi Ghufran , AL-Fayyadh Sadeq
Published: September 2022

Objectives: To assess pain severity for routine nursing procedures. As well as to compare pain severity during three measurement phases. And to find out the differences among routine nursing procedures pain severity.

Methods: An observational method for data collection and sample of 135 subjects who had met the study's inclusion criteria were targeted. The data collection started from January 18thto April 7th, 2022. 

Results: Patients were silently suffering pain during all three assessment phases: pre-during, and 20 minutes’ post-routine nursing procedures. Of equal importance, there is a statistically significant difference between all nursing procedures in terms of pain intensity.

Conclusion: The critically ill, mechanically ventilated patients who were recruited in this study, were silently suffering from a relatively high level of pain during their hospitalization period in the Intensive Care Unit. The highlighted case of silent suffering is a serious gap in both medical and nursing care quality that must be addressed both urgently and effectively.
Observability of fidelity decay at the Lyapunov rate in few-qubit quantum simulations
Authors: Porter Max D. , Joseph Ilon
Published: September 2022

In certain regimes, the fidelity of quantum states will decay at a rate set by the classical Lyapunov exponent. This serves both as one of the most important examples of the quantum-classical correspondence principle and as an accurate test for the presence of chaos. While detecting this phenomenon is one of the first useful calculations that noisy quantum computers without error correction can perform [G. Benenti et al., Phys. Rev. E 65, 066205 (2001)], a thorough study of the quantum sawtooth map reveals that observing the Lyapunov regime is just beyond the reach of present-day devices. We prove that there are three bounds on the ability of any device to observe the Lyapunov regime and give the first quantitatively accurate description of these bounds: (1) the Fermi golden rule decay rate must be larger than the Lyapunov rate, (2) the quantum dynamics must be diffusive rather than localized, and (3) the initial decay rate must be slow enough for Lyapunov decay to be observable. This last bound, which has not been recognized previously, places a limit on the maximum amount of noise that can be tolerated. The theory implies that an absolute minimum of 6 qubits is required. Recent experiments on IBM-Q and IonQ imply that some combination of a noise reduction by up to 100× per gate and large increases in connectivity and gate parallelization are also necessary. Finally, scaling arguments are given that quantify the ability of future devices to observe the Lyapunov regime based on trade-offs between hardware architecture and performance.
Optimal Control of the Behavior of Solutions to an Initial-Boundary Value Problem Arising in the Mechanics of Discrete-Continuum Systems
Authors: Kubyshkin E. P.
Published: September 2022

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Ensino superior militar: um estudo de viabilidade para a adoção de metodologias ativas de aprendizagem diante de um novo cenário de ensino na AFA
Authors: Nascimento Maria Estela Ferreira do
Published: September 2022

Este artigo trata de um estudo de viabilidade para a adoção de metodologias ativas de aprendizagem no ensino superior militar da Academia da Força Aérea(AFA), pois o isolamento social, causado pela pandemia, exigiu adaptações urgentes no processo de ensino-aprendizagem. Partindo da aplicação de uma pesquisa composta por 178 cadetes do 2º., 3º. e 4º. esquadrões e por 38 docentes que ministraram disciplinas do campo geral no 1º semestre de 2021, via Google forms e Whatsapp, o método de delineamento adotado foi uma pesquisa bibliográfica e uma pesquisa de campo. Os resultados mostraram que as mudanças no ensino superior militar vêm ocorrendo de forma moderada, exigindo adaptações urgentes dos alunos, no processo de ensino-aprendizagem da AFA, para que este continue on-line e seja cumprido o calendário acadêmico. Porém serão necessários investimentos tecnológicos em infraestrutura e em capacitação profissional para que avanços significativos ocorram. A adoção de metodologias ativas, somadas aos métodos tradicionais já utilizados, gerarão mais engajamento dos cadetes, para tanto devem ser identificados os estilos de aprendizagem predominantes, tanto entre os cadetes quanto entre os docentes, pois permitirá ter uma noção da forma como eles interagem com o ambiente de aprendizado ao ensino praticado. O ensino superior militar da AFA está mudando e existe viabilidade para avançar nas ações sobre as metodologias ativas de aprendizagem. Dessa forma, espera-se que esse estudo possa contribuir para avançar as ações já em andamento na Divisão de Ensino da AFA, de forma prática e aplicável.
O Grupo de Esquadrilhas de Aviação do Rio Grande do Sul: da necessidade de criação às causas de extinção
Authors: Assunção Fábio César Santos de
Published: September 2022

O presente estudo pretende, no ano em que comemoramos o Bicentenário da Independência do Brasil, assinalar o centenário de criação do Grupo de Esquadrilhas de Aviação do Rio Grande do Sul, trazendo a lume fatos ocorridos há 100 anos, quando o Exército Brasileiro, inserido em um amplo programa de modernização, adotou medidas que levaram à expansão de sua incipiente Aviação Militar para além da Capital Federal. O distanciamento em relação à década dos anos 1920, nos permite, por meio de um resgate histórico, analisar questões referentes à segurança nacional que levaram à criação do Grupo de Esquadrilhas de Aviação do Rio Grande do Sul, buscar explicações quanto aos motivos de sua efêmera existência e extinção, assim como analisar as suas contribuições em prol da defesa do território brasileiro e do desenvolvimento aeronáutico do País.
Gestão de segurança e plataformas digitais: aplicação dos relatórios de prevenção da Força Aérea Brasileira
Authors: Oliveira Eduardo Alves de
Published: September 2022

Na Força Aérea Brasileira, assim como na aviação em geral, o gerenciamento do risco está presente em diversas camadas da organização. Existem inúmeras atividades para a prevenção de acidentes aeronáuticos, entre elas estão os relatórios de prevenção(RELPREV). Esses relatórios são confeccionados pelos operadores que observem quaisquer condições que possam gerar risco para a atividade e afetar a segurança de voo. Atualmente, eles podem ser confeccionados somente por meio físico ou por computadores disponibilizados nas Bases Aéreas. Considerada a atual dependência que as pessoas atualmente possuem dos dispositivos móveis, em especial dos smartphones, aliada à praticidade que essa ferramenta proporciona para o usuário, este trabalho apresenta um estudo do processo de coleta dos dados e desenvolvimento de um web aplicativo, com vistas à appificação dos relatórios de prevenção.
Citizen science - science - industry: A case study in self-driving car
Authors: Cveticanin Livija
Published: September 2022

The paper discusses the connection between citizen science, science and industry in the field of STEM technologies. A methodology is established for connect?ing non-expert and expert groups on certain research topics in STEM with the aim to achieve better dissemination of knowledge from universities and research laboratories and industry. On the other hand, the CS projects give the response, recommendations, opinions, etc. to new technological achievements, which should correct and direct the further scientific re?search and innovation activities. The paper gives a case study of the CS-science-industry project realized among students of Faculty of Technical Sciences of Novi Sad and experts, about self - driving car. The aim of the project was to assess the degree of acceptability of this technical solution and, in correlation with experts, to make a recommendation for finish?ing or improving this vehicle according to the requirements of future users. CS actors were informed by experts about the importance and characteristics of these vehicles, as their introduction into public transport is expected in the near future. In coordination with the experts, the CS actors formed a questionnaire in which they asked questions that should indicate the degree of acceptability of the vehicle, but also gave the opportunity to express opinions and views on the vehicle. The answers on the questionnaire were put on a MS Teams platform. The analysis of the results of the CS project pointed to the low readiness of young people to drive a self-driving car of the 5th level (without human-driver), and gave recom?mendations and ideas to experts on finishing and modifying the vehicle. The work of CS and experts enabled CS actors, as future engineers and bearers of technical progress, to realize the importance of innovation and STEM technologies, and experts to gain better insight into the reaction and opinion of non-experts about their product.
Getting Students Ready for Accounting Spreadsheets: Training for Basic Spreadsheet Skills with Pre/Post Assessments
Authors: Borthick A. Faye , Schneider Gary P.
Published: September 2022

This case is intended to impart basic spreadsheet skills to students that do not have them. It trains them to transform data, create formulas (with functions, IF statements, and absolute references), aggregate data, look up values, configure pivot tables, sort data, record macros, and extract spreadsheet tasks from conversation. These skills are needed for subsequent spreadsheet analyses for solving business problems. Suitable for students that can copy cells and develop simple formulas, the case offers pre- and post-assessment questions. The case provides scaffolding resources: flashcards for Excel features, a work plan template, a narrated video for getting started with the work plan, and guidance (scripts with screenshots and narrated videos) for performing the spreadsheet tasks. Using the context of a gradebook application, which is familiar to students, the case minimizes the cognitive load students experience because they are not trying to learn accounting and spreadsheet skills simultaneously.
Casual Accounting Academics' Sense of Dignity and Inclusion in the Workplace
Authors: Khosa Amrinder , Burch Steven , Ozdil Esin
Published: September 2022

The delivery of accounting higher education in Australia has been heavily dependent on casual academic staff in light of increased enrolments of national and international students. Although research to date has emphasized the demanding aspects of casual teaching and the need for improvements to the working conditions of casual academics, little is known about casual academics lived experiences and the way they develop ethical understanding of their day-to-day working conditions. We provide in-depth empirical evidence about casual accounting academics employment experiences in Australian universities and highlight the factors that support and/or inhibit casual academics' sense of inclusion and dignity in the workplace. Using “workplace dignity” as our theoretical framework, we find that the stage of the casual academics' career and their aspirations for academia impact their views and experiences of dignity and inclusion in the workplace.
Deep learning predicts the differentiation of kidney organoids derived from human induced pluripotent stem cells
Authors: Park Keonhyeok , Lee Jong Young , Lee Soo Young , Jeong Iljoo , Park Seo-Yeon , Kim Jin Won , Nam Sun Ah , Kim Hyung Wook , Kim Yong Kyun , Lee Seungchul
Published: September 2022

Background: Kidney organoids derived from human pluripotent stem cells (hPSCs) contain multilineage nephrogenic progenitor cells andcan recapitulate the development of the kidney. Kidney organoids derived from hPSCs have the potential to be applied in regenerative medicineas well as renal disease modeling, drug screening, and nephrotoxicity testing. Despite biotechnological advances, individual differencesin morphological and growth characteristics among kidney organoids need to be addressed before clinical and commercial application. Inthis study, we hypothesized that an automated noninvasive method based on deep learning of bright-field images of kidney organoids canpredict their differentiation status.Methods: Bright-field images of kidney organoids were collected on day 18 after differentiation. To train convolutional neural networks(CNNs), we utilized a transfer learning approach. CNNs were trained to predict the differentiation of kidney organoids on bright-field imagesbased on the messenger RNA expression of renal tubular epithelial cells as well as podocytes.Results: The best prediction model was DenseNet121 with a total Pearson correlation coefficient score of 0.783 on a test dataset. W classifiedthe kidney organoids into two categories: organoids with above-average gene expression (Positive) and those with below-average geneexpression (Negative). Comparing the best-performing CNN with human-based classifiers, the CNN algorithm had a receiver operating characteristic-area under the curve (AUC) score of 0.85, while the experts had an AUC score of 0.48.Conclusion: These results confirmed our original hypothesis and demonstrated that our artificial intelligence algorithm can successfully recognizethe differentiation status of kidney organoids.
Daily spiritual experience in Indonesian elite athletes: able-bodied and disabilities
Authors: Sofyan Davi
Published: September 2022

Spirituality is the individual's belief in the existence, presence and involvement of transcendent divine beings in everyday life. This belief is accompanied by activities that aim to get closer to the transcendent figure (God). The aim of this research is to describe the level of daily spiritual experience in the elite able-bodied athletes and with disabilities, compare the spiritual experience level of the elite athletes of able-bodied and with disabilities, describe the socio-demography of elite athletes able-bodied and with disabilities. To support the study, we used a descriptive analysis method of 10 elite athletes consisting of five elite athletes with able-bodied athletes and five elite athletes with disabilities. The Daily Spiritual Experiences Scale was used in this study to measure daily spiritual experiences. The univariate test model was used to test the relationship between sociodemographic factors and the Daily Spiritual Experiences Scale score. The results show that of the 10 respondents have a different average score of daily spiritual experiences. Five able-bodied athletes show a very high spiritual level, while two athletes with disabilities exhibit a very high spiritual level and three people with a high spiritual level. Further research is needed to conduct in-depth studies related to the Daily Spiritual Experience in athletes by combining and analyzing quantitative and qualitative data.
Family intervention program for autism
Authors: Amira Luqyana Dhiya , Wagino Wagino , Budayasa I Ketut , Yuliyati Yuliyati
Published: September 2022

Interventions can minimize the impact of developmental barriers on autism. Inconsistent interventions result in behavioral deterioration. Parents have a big role to provide consistent intervention to children. This study aims to review home intervention programs that family can do at home. The research method used is a literature review. The data collection method used is the literature related to home-based autism interventions and family intervention. The results of the study show several programs that can be applied by families at home. The results showed the intervention models that can be done by family are ABA, PLAY, dan TEACCH. Through this study, it can be concluded that ABA is the most effective technique that can be used as a basis for implementing family interventions. Comprehensive interventions are also highly recommended for home interventions, such as modifying the environment and providing preschool life skills.
Communicating using storytelling method to children experienced sexual abuse and harassment
Authors: Pradanita Vista Nurasti , Setiawati Yunias , Yuniar Sasanti
Published: September 2022

Every year, sexual abuse against children is increasing. Globally, it is estimated that 3-31% of children had experienced sexual abuse. This harms children, including the impact of physical injury, neurobiological impact, and psychiatric, such as depression, anxiety, eating disorders, PTSD, drug abuse, self-harm, suicidal thoughts, and attempted suicide. To help children who are victims of sexual abuse, a special approach is required to ease the communication to children. Since children communicate using symbols, thus storytelling, which is part of the Play Therapy technique, is the right method to communicate awareness to children. With an approach using the storytelling method, hopefully, children will be able to understand the very situations, recognize and express their emotions properly, and minimize the negative impact after the abuse.
TPACK Development Model: Practice learn teach best through readiness organization learners and the nature of learning
Authors: Susanto Ratnawati , Rachbini Widarto
Published: September 2022

The period of the industrial revolution, which was full of advances in science and technology, required the competence of competitive graduates with modern literacy. The learning and teaching process requires the critical role of teachers who have mastery of technology, pedagogy, and scientific knowledge content expertise (TPACK). The important role of TPACK was increasingly seen in the learning process during the Covid-19 pandemic and at the same time demonstrated the reality of a learning crisis that had an impact on reading literacy and basic mathematics. So there is a need for fundamental improvements in teaching and learning practices, which start with improvements to the development of TPACK starting from the nature of learning from teachers and the readiness of educational institutions as learning organizations. The research objective is to identify the constructs of the TPACK development model - teaching and learning practice through Readiness of learning organization and The Nature of Learning. The stages of modeling and analysis of structural equations in the analysis of the first and second measurement models were carried out with CFA and using Smart PLS as a tool. The data collection technique used a 4-option Likert Scale with a questionnaire instrument with the number of respondents being 150 teachers of Public and Private Elementary Schools in DKI Jakarta Province. Sampling Technique with Simple Random Sampling. Data analysis was carried out to analyze the indicators that most dominantly influence TPACK. The study results concluded that the TPACK development model – teaching and learning practices can be constructed from the Readiness of learning organization and The Nature of Learning.
Epidemiological, Therapeutic and Evolutionary Profile of the Hemorrhoidal Pathology: Experience of The Gastroenterology Department of MED VI University Hospital of Morocco
Authors: Hala Aouroud , Hanane El Abassi , Errami Adil Ait , Oubaha Sofia , Samlani Zouhour , Krati Khadija
Published: September 2022

Hemorrhoidal pathology is a benign affection occupying a special place in medical practice, posing essentially therapeutic problems. The aim of this work was to study the epidemiological, therapeutic and evolutionary characteristics of this hemorrhoidal pathology.
We conducted a prospective study in the gastroenterology department of the CHU Mohamed VI of Marrakech over a period of 06 months (March 2019 - September 2019) where we collected 130 cases. The average age was 45.9 years with a clear predominance of men: sex ratio M / F = 1.95. The main reason for consultation was isolated rectal bleeding in 32% of patients. Proctologic examination revealed internal hemorrhoids, mainly stage II and stage III in 58.4% of patients, followed by external hemorrhoids in 16.9% of our patients. Paraclinically, CBC was performed in all patients with rectal bleeding and anemia was found in 17%. Thus, additional endoscopic exploration by colonoscopy was performed in 14.6% of cases returning to normal. The therapeutic management consisted primarily of hygienic and dietary measures in all our patients, 80% received drug treatment; while 25% received Instrumental rubber band ligation treatment after treatment failure, and only 16% of patients received surgical DTC. The evolution was marked by effective treatment in 78.46% of patients, while 28 patients presented minimal complications ranging from simple anal pain to a more or less extensive and serious infection. Despite the effectiveness of surgical treatment, it should be the last resort after a possible failure of medical and instrumental treatment.
The ethics of personalized medicine
Authors: Savelyeva MI
Published: September 2022

The early XXI century was marked with entry into the market of a great deal of medicinal preparations with a totally new molecular-oriented mechanism of action. These results could only be made possible through achievements in molecular and cellular biology and completion of the Human Genome Project, in particular. Many pathogenic mechanisms of different illnesses, including oncological and autoimmune ones, were deciphered. The data stimulated the search for totally innovative therapy methods targeting at the key links of the abnormal process pathogenetic chain, collectively known as ‘targeted therapy’. The issues of personalized medicine, including the ethics, are considered through the study of the Coriell Institute.