bluuebunny/crossref_metadata_2025 huggingface dataset:
Edukasi dan Pembagian Vitamin C Untuk Peningkatan Sistem Imunitas Pada Masyarakat Desa Prambangan, Gresik
Authors: Soekanto Ayly , Sahadewa Sukma , Rianti Emillia Devi Dwi , Erny Erny , Ama Fuad , Listyani Agusniar Furkani , Tania Putu Oky Ari , Emanuel Endrayana Putut Laksminto
Published: September 2023

Pandemi yang berlangsung pada tahun 2020 sampai dengan 2023 yaitu terjadinya Covid-19 yaitu penyakit infeksi yang disebabkan virus corona. Pandemi ini menyebabkan jumlah penderita yang terus bertambah. Indonesia yang merupakan negara terdampak wabah saat ini. Penyakit infeksi sangat bergantung pada sistem imunitas dari masing-masing individu. Salah satu cara untuk meningkatkan sistem pertahanan tubuh dapat dilakukan dengan memberikan nutrisi dan bahan yang terdiri komplek dari senyawa enzim, mineral, senyawa fenolik , vitamin dan flavonoid yang dapat menghambat perlepasan histamin dengan cara stabilisasi selaput sel lipid. Vitamin C berfungsi membuang radikal bebas kuat dalam plasma, melindungi sel dari zat oksidatif yang merusak karena radikal bebas ROS (reactive oxygen species). Upaya ini dapat meningkatkan sistem imunitas tubuh terutama imunitas selular. Oleh karena itu pengabdian kepada masyarakat ini bertujuan untuk memberikan edukasi dan pemberian vitamin C dalam rangka meningkatkan sistem imunitas warga.
Edukasi Kesehatan dan Keselamatan Kerja terhadap Risiko Cedera pada Pekerja Lepas Pengangkut Sampah di TPST Mulyoagung Kabupaten Malang
Authors: Fiddien Ahmad Naufal , Rahmawati Nurul Aini , Ronawati Dike Dwi , Anggraeni Nur Laili Sakti
Published: September 2023

Ergonomi adalah ilmu tentang perilaku manusia dalam bekerja dan sikap dalam bekerja. Pengelolaan sampah adalah bidang yang berkaitan dengan pengelolaan timbulan, penyimpanan, pengumpulan, pemindahan, pengangkutan, pengolahan dan pembuangan akhir sampah. Setiap pekerjaan memiliki bahaya akibat kerja, yang biasanya menimbulkan penyakit akibat kerja yang disebabkan oleh lingkungan kerja atau tempat kerja. Salah satu potensi bahaya di tempat kerja adalah ergonomi. Program pengabdian ini bertujuan memberikan edukasi kepada para pekerja pengangkut sampah di TPST Mulyoagung Kabupaten Malang tentang ergonomi mengenai definisi, gejala, penyebab, pencegahan dan sikap ergonomi yang tepat serta penanganan cedera. Metode yang digunakan dengan memberikan penyuluhan Kesehatan dan Keselamatan Kerja dengan menggunakan media leaflet dan pelaksanaan wawancara pre-test dan post-test berupa pertanyaan kepada para pekerja guna mengukur keefektifan dari penyuluhan yang diberikan. Hasilnya, terdapat peningkatan pengetahuan dan wawasan para pekerja mengenai kesehatan dan keselamatan kerja pada sikap postur tubuh ergonomi ketika bekerja serta cara penanganan ketika mengalami cedera.

Ergonomics is the science of human behavior at work and attitudes towards work. Waste management is a field related to the management of generation, storage, collection, transfer, transportation, processing and final disposal of waste. Every job has occupational hazards, which usually result in occupational diseases caused by the work environment or workplace. One of the potential dangers in the workplace is ergonomics. This service program aims to provide education to waste transport workers at TPST Mulyoagung Malang Regency about ergonomics regarding definitions, symptoms, causes, prevention and proper ergonomic attitudes as well as handling injuries. The method used is providing occupational health and safety education using leaflet media and conducting pre-test and post-test interviews in the form of questions to workers to measure the effectiveness of the education provided. As a result, there is an increase in workers' knowledge and insight regarding occupational health and safety regarding ergonomic posture when working and how to handle injuries.
Pencegahan Stunting dengan Pemberian Susu Kambing pada Balita di Dusun Ketawang Magelang
Authors: Wibowo Joko Wahyu , Yuniarti Heny
Published: September 2023

Stunting adalah kondisi gagal tumbuh pada Balita yang diakibatkan kekurangan gizi kronis sehingga anak menjadi pendek dibandingkan dengan anak usianya. Angka Stunting di Indonesia pada tahun 2022 masih di atas 21%, dan ditargetkan dapat turun di angka 14% di tahun 2024. Anak dengan stunting memiliki tubuh lebih pendek dari anak normal seusianya dan mengalami keterlambatan dalam berpikir yang dapat menimbulkan kerugian ekonomi bagi negara sebesar 2-3 persen dari Produk Domestik Bruto (PDB) per tahun. Tujuan dari pengabdian ini adalah meningkatkan kesadaran orangtua tentang pentingnya protein hewani, salah satunya dengan susu kambing untuk diberikan pada balita dalam mencegah dan menanganI stunting. Susu kambing memiliki kelebiihan seperti mudah diabsorbsi, tidak menggumpal, memiliki risiko kecil dalam menimbulkan alergi pada anak. Susu kambing memiliki globula lemak yang lebih kecil dan asam lemak rantai pendek dan menengah (MCT) yang lebih pendek daripada susu sapi, dan memiliki kemampuan metabolisme yang baik untuk menyediakan energi pada proses pertumbuhan anak. Metode pengabdian ini meliputi pemberian susu kambing pada balita dan pemberian edukasi pada orangtua balita tentang gizi seimbang pada balita. Kegiatan dilaksanakan di dusun Ketawang Magelang. Pelaksanaan kegiatan ini mendapat respons yang baik dari orangtua Balita maupun kader Kesehatan setempat. Diperlukan kegiatan berkelanjutan sebagai pendampingan dalam membantu orangtua Balita untuk memberikan makanan yang sesuai dengan kebutuhan tumbuh kembang buah hatinya.

Stunting is a condition of failure to thrive in toddlers caused by chronic malnutrition so that children are short compared to their age. The stunting rate in Indonesia in 2022 is still above 21% and is targeted to decrease to 14% in 2024. Children with stunting have shorter bodies than normal children of their age and experience delays in thinking which can cause economic losses to the country of 2 -3 percent of Gross Domestic Product (GDP) per year. The purpose of this service is to increase parental awareness about the importance of animal protein, one of which is goat's milk to be given to toddlers in preventing and treating stunting. Goat's milk has advantages such as being easily absorbed, does not clot, and has a small risk of causing allergies in children. Goat's milk has smaller fat globules and shorter short and medium-chain fatty acids (MCT) than cow's milk and has a good metabolic ability to provide energy for the child's growth process. This service method includes giving goat milk to toddlers and providing education to parents of toddlers about balanced nutrition for toddlers. The activity was carried out in the Ketawang village, Magelang. The implementation of this activity received a good response from toddlers' parents and local health cadres. Continuous activities are needed as assistance in helping parents of toddlers to provide food that is by the needs of the growth and development of their children.
Inventory Lot Sizing Decisions for Material Requirements Planning to Minimize Inventory Costs
Authors: Nurprihatin Filscha , Djajasoepena Rafie , Vargas Vanessa Bertholdo , Junior Moacyr Machado Cardoso , Vaezi Ali
Published: September 2023

Inventory control is one of the most important factors in achieving optimal organizational performance. Material Requirement Planning (MRP) is a common method used by businesses to manage inventories. This study focuses on a hydraulic firm that has been in operation since 2016. This research examines the planning of eleven components to get the best planning for the company. This study contributes to the integration of Moving Average (MA) and Exponential Smoothing (ES) forecasting techniques alongside the MRP and three lot sizing techniques, such as LFL, EOQ, and LUC. The minimum error values between MA and ES are evaluated and followed by the comparison between three lot sizing techniques. The result shows that ES (α=0.1) is selected as the best forecasting technique, and LUC presents the lowest total inventory cost. However, LUC is only 0.05 percent lower than what LFL presents. A larger difference is shown by EOQ with 14.57 percent higher than LUC which makes EOQ unlikely to be selected.
APLIKASI MONITORING SMART CHARGER ANDROID BERBASIS MIKROKONTROLER ESP8266 MENGGUNAKAN FLUTTER
Authors: Sulaeman Asvian , Thenata Angelina Pramana , Hakim Bhustomy
Published: September 2023

Smartphone merupakan perangkat yang sudah umum digunakan oleh masyarakat di zaman modern ini. Berdasarkan sistem operasinya smartphone terbagi menjadi dua jenis, yaitu IOS dan Android. Untuk menjalankan fungsinya, smartphone membutuhkan daya yang diambilnya dari baterai. Baterai yang digunakan didalam smartphone memerlukan pengisian ulang menggunakan charger. Sedangkan pengisian ulang tersebut bisa memakan waktu yang cukup lama sehingga pengisian daya sering kali tetap berlanjut walaupun baterai sudah terisi penuh yang sering mengakibatkan overcharge. Berdasarkan identifikasi masalah tersebut, penelitian ini bertujuan untuk merancang smart charger menggunakan mikrokontroler ESP8266 dan aplikasi monitoring yang dapat membaca dan menampilkan data baterai dari Android Smartphone dan mengirimkan sinyal kepada smart charger untuk menyambungkan / memutuskan arus yang terhubung saat melakukan pengisian daya baterai berdasarkan data baterai yang dibaca oleh aplikasi Android yang dibuat peneliti. Penelitian ini menggunakan framework Flutter sebagai User Interface Android dan Web, karena Flutter sudah mulai mendukung pemrograman multi-platform. Penelitian ini dilakukan pengujian terhadap alat menggunakan eksperimen perbandingan dengan charger biasa dengan smart charger yang dibuat peneliti dan blackbox pada aplikasi web dan android. Hasil penelitian ini adalah aplikasi web dan android yang dapat membaca dan menampilkan data baterai, smart charger yang dapat terhubung dengan internet dan menyambungkan / memutus arus charging berdasarkan data yang dikirim oleh aplikasi menggunakan MQTT Protocol. Adapun juga hasil pengujian aplikasi ini menggunakan eksperimen perbandingan yang membuktikan keberhasilan smart charger untuk menghentikan arus pengisian daya saat baterai sudah terisi penuh, dan blackbox terhadap aplikasi Web dan Android yang sudah dinyatakan berhasil. Berdasarkan hasil penelitian tersebut, dapat disimpulkan bahwa smart charger dirancang dapat digunakan untuk mencegah overcharging dengan cara memutuskan arus pengisian daya baterai saat baterai sudah terisi penuh, serta menampilkan informasi baterai tersebut menggunakan aplikasi Android dan Web. Adapun smart charger dapat memperpanjang umur baterai pada Android Smartphone.
Timing is everything: Improving predictions of winter New Zealand grass grub densities and associated damage from summer and autumn larval counts
Authors: McNeill Mark , Croy Russell , Van Koten Chikako , Shi Shengjing
Published: September 2023

Costelytra giveni is a serious pasture pest in New Zealand and accurate estimates of population densities are important to inform control measures. This species generally has a one-year life cycle so populations should either remain stable after eggs have hatched or decline due to larval mortality. Larval counts were obtained using a simple, standard and widely used sampling method from a series of soil cores collected from ryegrass research plots in Canterbury, New Zealand between 27 January and 16 June 2021 and a significant increase in population was recorded. Measurements on 27 January, 19 March and 5 May, represented only c. 8%, 25% and 63% of the mean densities measured on 16 June, respectively. The apparent increase in larvae is attributed to failure to find small 1st and 2nd instar individuals within the soil samples. Larvae increased in size as they transitioned from 1st to 3rd instar and later instar specimens were more easily discovered. An equation to describe the observed results provided date-related correction factors to allow a more realistic prediction of C. giveni larval densities in the winter following empirical larval counts. Larval counts measured on 27 January, 19 March, and 5 May, would need to be multiplied by 13, 4 and 1.6, respectively, to accurately estimate the larval density found on 16 June. This study showed that summer-autumn sampling using the current method can significantly underestimate winter C. giveni larval densities, potentially leading to unanticipated pasture production losses. Similar results were also found in 2022. While the equation provides a guide to population estimates, the caveat is that region and environment will influence population trends in any particular year.
"IoT-Based Vehicle Monitoring and Driver Assistance System Framework for Safety and Smart Fleet Management"
Authors:   Heriot-Watt University Malaysia, Rudrusamy Bhuvendhraa , Teoh Hock Chye ,   Heriot-Watt University Malaysia, Pang Jia Yew ,   Heriot-Watt University Malaysia, Lee Tou Hong ,   TMS-Lite Sdn Bhd, Chai Sung Choong ,   CPeEnergy Sdn Bhd
Published: September 2023

Curbing road accidents havealways been one of the utmost priority of nations worldwide. In Malaysia, the Traffic Investigation and Enforcement Department reported that Malaysia’s total number of road accidents haveincreased from 373,071 to 533,875 in the last decade. One of the significant causes of road accidentsis the driver’s behaviors. However, to regulate drivers’ behavior by the enforcement team or fleet operatorsischallenging, especially for heavy vehicles. In our research, we have proposed the Internet of Things (IoT) scalability framework and its’ emerging technologies to monitor and alert driver’s behavioral and driving patterns to reduceroad accidents. To prove this work, we have implementeda lane tracking,and iris detection algorithm, to monitor and alert the driver’s behavior when the vehicle sways away from the lane, and to detect if the driver is feeling drowsy. We implemented electronic devices such as cameras, a global positioning system module, a global system communication module, and a microcontroller as the hardware for an intelligent system in the vehicle. We also appliedface recognition for person identification using the same in-vehicle camera and recorded the working duration for authentication and operation health monitoring. With the GPS module, we monitored and alerted against permissible vehicle’s speed accordingly. We integrated IoT on the system for the fleet centre to monitor and alert the driver’s behavioral activities in real-time through the user access portal. We have validated it successfully on Malaysian roads. The outcome of this pilot project ensuresthe safety of drivers, public road users, and passengers. The impact of this framework leads to a new regulation by the government agencies towards merit and demerit system, real-time fleet monitoring of intelligent transportation systems, and socio-economy such as cheaper health premiums. The big data can be used to predict the driver’s behavioral in the future.
Validating The Impact of Psychological, Physical, and Social Factors On Workplace Well-Being at Construction Sites
Authors:   University of Malaya, R. Radzi Afiqah , A. Rahman Rahimi ,   Universiti Malaysia Pahang, Alias Ahmad Rizal ,   Universiti Malaysia Pahang, Almutairi Saud ,   Qassim University
Published: September 2023

A good workplace well-being environment can increase employee resilience, work engagement, project performance, and productivity, as well as reduce sick days. Research suggests that physical, psychological, and social factors are the underlying factors for a good workplace well-being However, the underlying factors for workplace well-being at construction sites may differ. This study aims to validate the relationships between underlying factors (i.e., physical, psychological, and social) and workplace well-being at construction sites. A questionnaire survey was developed from a list of factors influencing workplace well-being and distributed to construction professionals. The collected data was analyzed using confirmatory factor analysis (CFA) to validatethe relationships between the underlying factors and workplace well-being at construction sites. The analysisrevealed that physical, psychological, and social factors are also influencing workplace well-being at construction sites. Researchers and industry practitioners can use these findings to confidently establish strategies to increase workplace well-being of construction workers.
Statistical Analysis of Accident Patterns and The Causes at A State Road in Perlis
Authors:   University Malaysia Perlis, Doraisamy Geetha , Abdul Rahman Farahiyah ,   University Malaysia Perlis, Ayob Afizah ,   University Malaysia Perlis, A.Rani Hafnidar ,   Universitas Muhammadiyah Aceh, Ibrahim Mohd Khairul Alhapiz ,   Malaysian Institute of Road Safety Research, Harnaeni Senja Rum ,   Universitas Muhammadiyah Surakarta
Published: September 2023

According to data from the World Health Organization, approximately 1.3 million road users are at high risk of road traffic accidents every year. This study aims to assess accident patterns and causes on a state road between Kangar and Alor Setar. The evaluation of accident pattern employed include the chi-squared test (CST) and the level of service (LOS) survey. Analysis using Pearson CST reveals that age and vehicle type are significant factors in accidents. Specifically, individuals below 30 years old have a higher likelihood of being involved in accidents (ρ= 0.037), while motorcycles are more prone to accidents (ρ= 0.000). However, gender does not appear to impact accident involvement significantly (ρ= 0.911). The LOS E category indicates unstable traffic flows during Monday and Friday evenings. To evaluate accident causes from the perspective of road users, a questionnaire was used, and its validity and reliability were ensured through a pilot study. Four hypotheses were developed, examining human factors, vehicle factors, environmental factors, and road condition factors as independent variables. The results reveal that a majority of road users (33.3%) travel 1 to 3 times per week, with 23.1% of them being involved in accidents on this road. The validity test using the structural model identifies road factors (t= 6.166, ρ= 0.000), vehicle factors (t= 4.3399, ρ= 0.000), and human factors (t= 2.893, ρ= 0.005) as the most significant contributors to accidents. Hence, it is crucial for authorities to prioritize countermeasures focusing on these factors to reduce accidents on this road.
The Implementation of Maintenance System in Malaysia’s Public Housing at Kota Bharu, Kelantan
Authors:   Universiti Malaysia Pahang, Azmy Nurhidayah , Ahmad-Nazri Elly HF ,   Universiti Malaysia Pahang, M Yusof Liyana ,   Universiti Malaysia Pahang, M Gad Ghada ,   California State Polytechnic University
Published: September 2023

Establishing an effective maintenance system in public housing buildings is essential in ensuring the building operates optimally and enhances residents' satisfaction. However, the maintenance management in Malaysian public housing is considered low, particularly on leaky roofs, dysfunctional elevators and obstructed pipes. Consequently, the deterioration of facilities and services makes the residents dissatisfied. Consequently, the study aims to determine the current implementation and effectiveness of the maintenance system for public housing byfocusing on the residents' satisfaction level and the practice of the maintenance personnel. Surveys were conducted with residents and maintenance personnel from the Projek Perumahan Rakyat Kota Bharu's public housing. A total of 230 questionnaires were considered valid and analyzed to rank the residents' satisfaction level towards public housing maintenance and the practice of the maintenance personnel in public residential buildings. The data was analyzed using the Mean Analysis in the Statistical Package for Social Science (SPSS). The result revealed that the residents are satisfied with the maintenance system's performance, with an electrical system as the most satisfying maintenance performance rated by the residents, compared with other aspects of the maintenance performance factors, with a mean score of 3.94. However, several aspects of the maintenance system, namely cleaning services, security system, and time for repairing the defects, still need improvement to enhance the maintenance quality of public housing in Malaysia.
Shear Capacity of Reinforced Concrete Beam with an Opening Retrofit Using Steel Fiber and Metakaolin
Authors:   Universiti Tun Hussein Onn Malaysia, Zulkifli Batrisyia , Ali Noorwirdawati ,   Universiti Tun Hussein Onn Malaysia, Abdul Hamid Noor Azlina ,   Universiti Tun Hussein Onn Malaysia, Salleh Norhafizah ,   Universiti Tun Hussien Onn Malaysia, Abdullah Siti Radziah ,   Universiti Tun Hussein Onn Malaysia
Published: September 2023

The presence of opening in the shear zone of beams can significantly affect the load-carrying capacity and the shear resistance of the beams. Previous research hasshown that strengthening provides promising results in increasing the performance of the beams with opening. Therefore, this studypresentsthe experimental work of five (5) reinforced concrete beam with opening at shear zone,added with steel fibre and metakaolin to increase the shear capacity of the beam. All beams were cast and tested under four-point bending test. One beam served as the control specimen, two beams hadone and twoopening respectively while the other two beams also had one and two opening butwith added steel fibre and metakaolin. The type of steel fibre used was a hooked-end steel fiberwith the dimensions of 0.9mm in diameter, 60mm in length.0.5% of steel fiber wasadded by volume of beam, and 5% of metakaolin by volume of beamwere used. From the experimental results, it was found that the two beams with added steel fibre and metakaolin shows an increase in shear capacity compared with the beams with opening without the steel fibre and metakaolin. The highest shear force recorded was 79.11 kN (beams with added steel fibre and metakaolin) which showedan increase ofabout 54.3 % compared with the same beam with opening without added steel fibre and metakaolin.
A Study of Weld Seams on Low Carbon Steel ABS Grade a Marine Plates Using SMAW Process
Authors:   Curtin University, Zen Kai Lester Chin , Naa Sung Aun ,   Vitrox College, Tchan Edwin Jong Nyon ,   Curtin University
Published: September 2023

Understanding the impact of welding parameters and welder skill on weld quality is crucial. However, it is the lack of comprehensive studies that consider the welding parameters and welder-introduced defects when analyzing the mechanical and metallurgical behaviors of low carbon steel welds using the SMAW process. The research aims to study and assess the impact of weld seams of low carbon steel ABS Grade A marine plate of 12.7mm thick using manual SMAW process as per AWS D1.1 structural welding code requirements and fulfilments of ASME Section IX pressurized equipment welding code requirements too. Different voltages, currents, and travel speeds were used to weld the test specimen plates. After the manual SMAW process, a series of testing techniques, including non-destructive tests, such as VT and RT, and destructive tests, such as tensile tests, bend tests, impact tests, microhardness tests, and metallographic examination has been conducted to assess/evaluate on the welded seam profiles and analyses/determines whether the accepted welded seam profiles have fulfilled the relevant welding code requirements. From the series of assessments and analyses, it is confirmed that the welded test specimen 1 having the welding parameters (i.e., voltage 23 V, current 70 A, and travel speeds 56.52 – 312.50 mm/min, having a range of heat inputs from 0.31kJ/mm to 1.71kJ/mm) is accepted as the quality good weld seam.
The Development of a Vehicle Recovery Remanufacturing Tool: An Interior Parts Analysis Indicator
Authors:   Universiti Tun Hussein Onn Malaysia, Poapalan Pravenkumar , Ho Fu-Haw ,   Universiti Tun Hussein Onn Malaysia
Published: September 2023

The rapid growth of the automotive industry has placed a significant demand on earth resources such as metal and minerals. This has led to a shortage of materials and an increase in material prices. One of the solutions to enhance resource management is to perform parts remanufacturing during product design to ease the part classification. However, this initiative is not yet widely explored, particularly in terms of guideline or tool development. For example, the recyclers have no idea on how to decide the suitability of an automotive part to be remanufactured. This study aims to develop a vehicle recovery analysis guideline to assist those in the automotive industry in developing vehicles with higher remanufacturing rates during the product development stage. In this study, there are three main criteria, and 11 sub-criteria were determined from the literatures that influences the vehicle part remanufacturing rate. These criteria are classified into three main categories namely: selection of material, method of joining, and mechanical design. Next, quantitative approach namely Analytic Hierarchy Process (AHP) methodology was applied to collect the pairwise comparison data from the automotive industry practitioners. The gathered data were analyzed using Expert Choice V11 software to determine the criteria priority weightage to influence the remanufacturing activities. From the analysis, the three most influencing criteria based on global weightage are type of joining (0.216), durability (0.131), type of material (0.103), whereas the criteria that least being considered are cost of material(0.018), cleanability (0.04), and design complexity (0.041). From the obtained priority weightage, these data were used to develop an assessment tool using Microsoft Excel software. The assessment tool was validated by experts to ensure its feasibility tobe applied as a remanufacturing guideline. Positive feedbacks were obtained from the experts especially on the outputs of assessment tool which able to assist the practitioner in product design and ease the process of remanufacturing.
Design and Analysis of Coconut Tree Climbing Bike Using Reverse Engineering Technique
Authors:   Universiti Tun Hussein Onn Malaysia, Yahaya Siti Nurul ‘Ain , Azlan Hj. Mohd Azwir ,   Universiti Tun Hussein Onn Malaysia
Published: September 2023

Coconut trees have hard-shelled fruits that grow as high as eight meters to 30m. It is one of the most important crops in the world. Coconut is considered as a healthy food and is used in a various foods and medicine. In this research, a coconut tress climbing bike was designed using reverse engineering technique based on availableinternet media resources. This research aims to solve the problem faced by most climbers who do not have thecomplete equipment and technology to climb coconut trees. Throughout the investigation and analysis,references based on Ganapathi Bhat’s climbing bike design were studied to obtain the necessary informationincluding load capacity, weight, price, size and estimated speed. Simulation and engineering analysis is made using SolidWorks software to evaluate specification. Based on the analysis and simulation result, this design is able to support and carry a user weighing 80kg to climb a coconut tree. The maximum speed of a coconut tree climbing bike is estimated at 0.6m/s. The coconut tree climbing bike design has a size of 717mm(L) x 539mm(W) x 415mm(H) and its estimated weight is 29.7kg. The selling price of this bike is estimated to be approximate RM 3500. This project is expected to provide information to the readers to obtain the coconut tree climbing bicycle technology that has already been in the small regional market in India. Hence, hopefully this research can help tointroduce this technology in more detail to the Malaysia universities and citizens.
Characteristics and Preliminary Study of Ceramic Concretes
Authors:   Universiti Tun Hussein Onn Malaysia, Ab Hadi Farhany Izzaty , Abdul Latif Noradila ,   Universiti Tun Hussein Onn Malaysia, Syed Abu Bakar Sharifah Adzila ,   Universiti Tun Hussein Onn Malaysia, Ahmad Sha’rainon Farah Nur Dini ,   Universiti Tun Hussein Onn Malaysia, Abdul Malik Muhammad Syafiq ,   MMC Engineering Sdn Bhd
Published: September 2023

One of the most adaptable and frequently used building materials in the world is concrete. It is flexible in terms of size and shape, sturdy, long-lasting, low-maintenance, fireproof, and easy to use. However, further research is needed to increase the durability and sustainability of this material since concrete technology is still indeveloping industry. Therefore, it's crucial to comprehend how microstructure and characteristics interact in terms of how they affect concrete's strength, dimensional stability, and durability.The findings of this research arecrucial in identifying the properties and characteristics of the ceramic concrete used for bridge construction or others. Advanced research to ascertain the hardness and physical qualities and features of ceramic concrete material is required. Thus, it will help to produce a reliable data for engineer to refer for their future works or project. To ascertain its hardness and physical characteristics, research has been conducted on ceramic concrete for several types of grades. In the current study, the ceramic concrete was tested through the physical and Vickers-hardness tests. The X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) on samples were performed to observe the phases and morphology of the ceramic concrete, respectively. For results of physical testing, the density and water absorption correlate to each other by the denser of the sample, the lower of water absorption and the porosity level of the ceramic concrete. Based on the Vickers micro hardness test, it can be seen that longer curing days affected the hardness, where the concretes of grade 30 and 40 at 28 curing days had better hardness value. Next, Scanning Electron Microscopy (SEM) on samples shown almost same microstructure, whilethe dominant phase of all ceramic concrete grades was SiO2 by the XRD analysis. In summary, better properties of ceramic concretes were indicated at 28 curing days for both grades of ceramic concretes.
Eğitim Örgütlerinde Oluşan Örgütsel Patolojiler ve Patolojilere Karşı Verilen Yönetici Tepkileri
Authors: ÖZDEMİR Tuncay Yavuz , YILDIZ YALÇIN Aslı
Published: September 2023

Bu araştırmanın amacı eğitim örgütlerinde meydana gelen örgütsel işlev bozukluklarına sebep olan örgütsel patolojileri, yönetici algısı ile irdelemek ve oluşan patolojilere karşı gösterilen yönetsel tepkileri betimlemektir. Araştırmanın çalışma grubu, 2020-2021 eğitim öğretim yılında Türkiye’nin doğusunda bulunan bir ilde görev yapan 61 okul yöneticisinden oluşmaktadır. Araştırmada nitel araştırma desenlerinden fenomenoloji yaklaşımı kullanılmıştır. Araştırmanın güvenirliliği, Miles ve Heberman’ın (1994) geliştirdiği fomül kullanılarak ~%92 bulunmuşutr. Elde edilen veriler içerik analizi ile kategorize edilmiş ve yorumlanmıştır. Veriler, sebep olabilecek davranış türleri göz önünde bulundurularak incelenmiştir. İçe kapanık olma ve fikir paylaşmama davranışları örgütsel sessizlik; değer benimsemem ve karar uymama davranışları örgütsel sapma; alınganlık ve paranoyaklık davranışları örgütsel depresyon ve tükenmişlik davranışı ile örgütsel yabancılaşma şeklinde dört temada gruplandırılmış ve incelenmiştir. Araştırma sonuçlarına göre, okul yöneticilerinin örgütsel patolojiler karşısında verdikleri tepkiler, iletişim kurma, uyarma, yaptırım, paylaşma, uzak durma, tepkisizlik ve destek şeklinde olduğu görülmüştür.
Okul Öncesi Eğitim Programlarında Sosyal Bilgiler: Amerika Birleşik Devletleri
Authors: YÜKSEK USTA Semiha , KİMZAN İlayda
Published: September 2023

Araştırmada Amerika Birleşik Devletleri Eyaletlerinin okul öncesi eğitim programlarında yer verdikleri sosyal bilgiler (tarih, coğrafya, ekonomi, vatandaşlık) kazanımlarının incelenmesi amaçlanmıştır. Veri toplama yöntemi olarak doküman analizinin kullanıldığı bu nitel araştırmanın çalışma grubuna dahil edilen eyaletler ölçüt örneklem yoluyla belirlenmiştir. Ülkenin 50 eyaleti arasından İnsani Gelişme Endeksi (İGE) (2018) verilerine göre en yüksek ortalamaya sahip 10 eyaletin okul öncesi eğitim programlarının sosyal bilgiler kazanımları incelenmiştir. Veriler içerik analizi yoluyla analiz edilmiştir. Araştırmanın sonucunda, okul öncesi coğrafyada harita ve küre gibi temsillerin kullanımı, ev okul gibi tanıdık yerlerin özellikleri, kültürel özellikler ve farklı kültürlere yönelik kazanımların ön planda tutulduğu görülmüştür. Tarih temasında geçmiş ve günümüz arasında kıyaslamalar yapmaya ve ulusal geleneksel kutlamalara ağırlıklı olarak yer verilmektedir. Ekonomi temasında ise ekonomiye dair temel kavramlar ve meslekler gibi topluluk yardımcıları hakkında kazanımlar öne çıkmaktadır Son olarak Vatandaşlık temasında okul öncesi için demokratik süreçlere aktif katılımın ve topluluk kurallarının sıklıkla yer verilen kazanımlar olduğu görülmüştür. Türkiye’de uygulanan Okul Öncesi Eğitim Programının güncelleme ve genişletilmesine yönelik çalışmalar yapıldığı takdirde mevcut araştırma, bu anlamda araştırmacılara bilimsel dayanak sağlaması açısından öngörü ve önem taşımaktadır.
Reduced Proliferative Potential with Conserved Stem/Stromal Phenotype of Human Umbilical Cord Mesenchymal Stem Cells in Placental Syndromes: A Prospective Cohort Study
Authors: Marino Luigi , Castaldi Maria Antonietta , Fulgione Caterina , Castaldi Salvatore Giovanni , Manzo Paola , Giudice Valentina , Picone Francesca , Campitiello Maria Rosaria , Polichetti Mario , Guida Maurizio , Selleri Carmine , Serio Bianca
Published: September 2023

Background: Pathophysiology of placental syndromes is still unclear, and umbilical cord-derived mesenchymal stem cells (UC-MSCs) might play a role in the development of these syndromes. In this prospective cohort study, we evaluated proliferative abilities of two types of UC-MSCs, Wharton’s Jelly MSCs (WJ-MSCs) and cord blood MSCs (CB-MSCs), in placental syndromes. Methods: A total of 16 cord blood and umbilical cord samples were seeded and cultured until MSC growth potential exhaustion. Cumulative population doublings were employed for studying growth potential, and flow cytometry immunophenotyping for verification of mesenchymal markers. Results: In our prospective cohort study, on one hand CB-MSCs from pathological pregnancies showed a significant reduction of growth potential, on the other hand WJ-MSCs showed a trend toward higher growth potential. This trend is consistent with the well-known faster-growing phenotype of WJ-MSCs under low oxygen atmosphere. Moreover, it’s well understood that chronic hypoxia is a main feature of both intrauterine growth restriction (IUGR) and preeclampsia, thus, our data perfectly match with the well-known clinical characteristics. Conclusions: Growth potential of CB-MSCs obtained from placental syndromes tended to be reduced compared to that of MSCs from healthy pregnancies. Our results need to be confirmed in larger in vitro studies, as a higher number of CB- and WJ-MSC would better clarify pathophysiology of placental syndromes.
Effect of Shorter Pretreatment Time on Clinical and Neonatal Outcomes in Human Blastocysts Vitrification after Artificial Shrinkage
Authors: Zhang Liuguang , Sciorio Romualdo , Li Yuhu , Li Ning
Published: September 2023

Background: Prolonged pretreatment time may be harmful to frozen embryo’s developmental potential. This study was conducted to evaluate the effect of different equilibration times on the clinical and neonatal outcomes of frozen-warmed blastocyst transfer. Methods: This is a retrospective study based on data collected from our medical records from March 2018 to March 2022 and including a total of 763 expanded blastocysts from 538 warming blastocyst cycles. These cycles were divided into two groups according to the equilibration time: (A) 6–7 minutes, and (B) 9–10 minutes. The survival rate, clinical, and neonatal outcomes were investigated. Results: The survival, implantation, and clinical pregnancy rates of vitrified-warmed shrinkage blastocyst were not different between the two groups. Other variables analyzed including live birth, multiple gestation, and neonatal outcomes were similar between the two groups. Conclusions: The results of this study illustrated that vitrification of artificially collapsed blastocysts with a shorter equilibration time (6–7 minutes) and pre-vitrification is able to lead to similar clinical and neonatal outcomes in patients undergoing assisted reproductive technology (ART).
The Role of Multiparametric MRI in the Local Staging of Prostate Cancer
Authors: Oliveira Tiago , Amaral Ferreira Luís , Marto Carlos Miguel , Marques Cristina , Oliveira Carlos , Donato Paulo
Published: September 2023

Prostate cancer ranks as the second most frequently diagnosed cancer globally among men and stands as the fifth leading cause of cancer-related death in males. Hence, an early and precise diagnosis and staging are critical. Traditional staging is based on clinical nomograms but presents a lower performance than prostate multiparametric magnetic resonance imaging (mpMRI). Since tumor staging serves as the basis for risk stratification, prognosis, and treatment decision-making, the primary objective of mpMRI is to distinguish between organ-confined and locally advanced diseases. Therefore, this imaging modality has emerged as the optimal selection for the local staging of prostate cancer, offering incremental value in evaluating pelvic nodal disease and bone involvement, and supplying supplementary insights regarding the precise location and disease extension. As per the Prostate Imaging Reporting & Data System v2.1 guideline, a comprehensive and accurate mpMRI requires several key sequences, which include T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI) for morphological assessment, with T2WI serving as the cornerstone for local staging. Additionally, diffusion-weighted imaging (DWI) and dynamic sequences acquired with intravenous administration of paramagnetic contrast medium (DCE) are crucial components. It is worth noting that while MRI exhibits high specificity, its sensitivity in diagnosing extracapsular extension, seminal vesicle invasion, and lymph node metastases is limited. Moreover, mpMRI has its own constraints and is not as effective in detecting distant metastases or evaluating lymph nodes, for which extended pelvic lymph node dissection remains the gold standard. This review aims to highlight the significance of mpMRI in prostate cancer staging and provide a practical approach to assessing extracapsular extension, seminal vesicle invasions, and the involvement of adjacent organs and lymph nodes.
Role of Ferroptosis in Glial Cells after Ischemic Stroke
Authors: Xu Shu-Ying , Ni Si-Ming , Zeng Chun-Li , Peng Yong-Jun
Published: September 2023

Ischemic stroke (IS) is the predominant cause of morbidity and mortality worldwide. Ferroptosis, a new type of programmed cell death, has been shown to play a crucial role in IS pathogenesis. Traditionally, research focused on neurons did not uncover specific positive results for IS. However, glial cells have recently received interest as promising targets for IS treatment, not only for their structural function but also in the iron transfer between glia and neurons, which indicates a promising glia–neuron crosstalk in mediating the IS process and ischemia/reperfusion-associated neuropathology, showing their affiliation with ferroptosis. This review addresses the major phenomena of iron metabolism and the process and regulation of ferroptosis, with a particular focus on their impact on IS pathology. The review discusses iron homeostasis, the biology of reactive oxygen species, and lipid peroxidation for modulating the process of IS-induced ferroptosis in different glial cells. We then review recent therapies that leverage ferroptosis modulation for the treatment of IS. Extensive preclinical and clinical research is necessary to fully understand the roles of glia–neuron crosstalk and ferroptosis in IS.
The Role of NLRP3 Inflammasomes in Trained Immunity
Authors: Lee Gilyoung , Ahn Huijeong , Lee Eunsong , Lee Geun-Shik
Published: September 2023

Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis. Trained immunity is the induction of memory in innate immune cells by epigenetic reprogramming due to repeated inflammatory stimuli that alter the inflammatory response and increase resistance to infection or disease. Although it is speculated that nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR), and the NLR family pyrin domain containing 3 (NLRP3) inflammasomes respond to various inflammatory stimuli and are associated with trained immunity, the exact relationship is still unclear. This paper aims to introduce data from recent research on the role of inflammasomes in trained immunity through cellular immunometabolic and epigenetic reprogramming. It also suggests a new therapeutic strategy for inflammatory diseases through the complementary regulation of inflammasomes and trained immunity.
The Role of Prohibitin-2 in Diseases
Authors: Liu Fang , Zhang You , Guo Zhiyong , Ren An-Jing
Published: September 2023

Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis. Recently, there has been growing interest in the biological function of PHB2. This article primarily discusses the recent advances in the role of PHB2 in diseases.
In Silico Identification of Therapeutic Targets and Novel Drug Candidates for Malignant Peripheral Nerve Sheath Tumors
Authors: Wei Min , Fan Jianfeng , Peng Renjun , Ding Xiping , Xi Jian , Huang He
Published: September 2023

Background: Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive form of sarcomas with a poor prognosis and limited treatment options. Therefore, new therapeutic targets are urgently needed to identify novel drugs. Methods: Based on the Gene Expression Omnibus database, an integrated analysis was performed to identify differentially expressed genes (DEGs) in MPNSTs compared to neurofibromas (NFs). Then functional enrichment analyses, protein-protein interaction (PPI) network construction, and hub gene selection were conducted. We explored DEG-guided repurposable drugs to treat MPNST based on the Library of Integrated Network-Based Cellular Signatures (LINCS) database. Furthermore, the binding affinity between predicted drug candidates and the MPNST-associated hub gene was calculated using molecular docking. Results: We identified 89 DEGs in common with all three MPNSTs datasets. In the PPI networks, twist family bHLH transcription factor 1 (Twist1) with higher node degrees was further evaluated as a therapeutic target. Cytochalasin-d, cabozantinib, everolimus, refametinib, and BGT-226 were extracted from the LINCS database, which showed lower normalized connectivity scores (–1.88, –1.81, –1.78, –1.76, and –1.72, respectively) and was considered as drug candidates. In addition, the results of molecular docking between the five drugs and Twist1 showed a binding affinity of –6.61, –7.03, –7.73, –3.94, and –7.07 kcal/mol, respectively. Conclusions: Overall, our results describe the importance of Twist1 in MPNST pathogenesis. Everolimus was also found to be a potential therapeutic drug for MPNSTs.
EPO rs1617640 A>C is a Protective Factor for Chronic Obstructive Pulmonary Disease: A Case Control Study
Authors: Wang Yunchao , Li Zhi , Zhang Xiaoyi , Lin Ao , Chen Cuiyi , Zeng Xiaobin , Pan Yujie , Mao Chun , Xie Chenli , Huang Dongsheng , Deng Yibin , Zhang Xuhui , Lu Jiachun , Wang Xinhua
Published: September 2023

Background: The occurrence and development of chronic obstructive pulmonary disease (COPD) are regulated by environmental and genetic factors. In hypoxia, Erythropoietin (EPO) satisfies the body’s need for oxygen by promoting the production of red blood cells. Hypoxia was proven to be a common physiological condition in COPD progression and associated with many complications. Some studies have found that EPO is involved in the development of COPD. But the mechanism has not been fully proven. Methods: We conducted a case-control study enrolled 1095 COPD patients and 1144 healthy controls in Guangdong Province to evaluate the association between EPO polymorphisms (rs1617640 A>C, rs507392 A>G, rs564449 G>T) and COPD susceptibility. 872 participants from southern Gansu Province were recruited to verify the effect of EPO polymorphisms on lung function. Results: EPO rs1617640 C allele reduced COPD susceptibility in southern Chinese significantly (AC vs. AA: adjusted Odds ratio (OR) = 0.805, 95% CI = 0.669–0.969; AC+CC vs. AA: adjusted OR = 0.822, 95% CI = 0.689–0.980). However, there was no association between rs507392 A>G and rs564449 G>T polymorphisms and COPD susceptibility (p > 0.05). We further observed that the rs1617640 C allele was associated with higher FEV1 and FVC in Guangdong and Gansu populations significantly (both p < 0.05). In brief, the level of FEV1 and FVC increased with the C allele number. We modeled the relative risk for men and women, in which the population-attributable risks chances were 0.449 (0.258–0.641) and 0.262 (0.128–0.396) respectively. In this model, smoking status, coal as fuels, education level, and rs1617640 A>C were finally retained for males, while smoking status, biomass as fuels, and1617640 A>C were retained for females. In the end, using the method developed by Gail and Bruzzi, we fitted a 10-year absolute risk model for southern Chinese with different individual relative risks, which was presented as a table. Conclusions: In conclusion, this study found that EPO rs1617640 A>C polymorphism is associated with COPD susceptibility in southern Chinese, and the C allele was associated with better lung function. In addition, it could also be considered a genetic marker associated with environmental factors to predict the absolute 10-year risk of COPD in southern Chinese.
Antiproliferative Activity of Lignans from Olea ferruginea: In Vitro Evidence Supported by Docking Studies
Authors: Rauf Abdur , Rashid Umer , Atta Aniqa , Khan Ishaq , Shah Zafar Ali , Mobeen Bushra , Javed Aneela , Alomar Taghrid S. , Almasoud Najla , Naz Saima , Ahmad Zubair , Ribaudo Giovanni
Published: September 2023

Background: The aim of the current study was to investigate the anticancer potential of bioactive compounds isolated from the leaves of Olea ferruginea (O. ferruginea). Lignans from O. ferruginea were previously described to possess antibacterial, antileishmanial, and antioxidant properties. Nevertheless, the antiproliferative activity of cycloolivil (1), ferruginan (2), and ferruginan A (3) have not been investigated in depth. Methods: The compounds were isolated from the ethyl acetate fraction of the leaves extract of O. ferruginea. The isolated molecules were evaluated for their anticancer activity against U-87 MG malignant glioma cells. In parallel, molecular docking studies were also performed to investigate the interaction of the compounds with a duplex DNA sequence and epidermal growth factor receptor (EGFR). Results: In vitro tests showed that all three compounds inhibit U-87 MG malignant glioma cell proliferation dose-dependently in the µM range, and ferruginan A (3) was highlighted as the most promising compound of the set. Molecular docking studies showed that the compounds could interfere with double stranded DNA possessing a cisplatin 1,2-d(GpG) intrastrand cross-link and EGFR. Conclusions: Overall, the findings suggest that the tested compounds from O. ferruginea may represent a starting point for the identification of novel tools to inhibit glioma cell proliferation.