bluuebunny/crossref_metadata_2025 huggingface dataset:
Uso do modelo EPANET na definição de uma proposta de reabilitação do sistema de distribuição de água da cidade de Forquilha/CE
Authors: Costa Luis Henrique Magalhães , Ximenes Clenilton Lima , Silva Antonio Hermano Gomes Da
Published: December 2024

O município de Forquilha, localizado no norte do estado do Ceará, tem seu saneamento básico operado pela CAGECE- Companhia de Água e Esgoto do Ceará. O sistema de distribuição de água vem sofrendo desconformidades em seu abastecimento, fazendo-se necessário a realização de estudos que apontem alternativas que diminuam os impactos provocados pela instabilidade no fornecimento de água. A fim de diagnosticar as condições de operação e propor alternativas técnicas de regularização para o sistema de distribuição de água, principalmente nos bairros cidade dos anjos e de Deus, considerados os mais críticos pela descontinuidade do abastecimento, fez se necessário o uso da modelagem hidráulica, através da utilização do software EPANET. Com a utilização deste software foi possível modelar a situação atual e propor novos cenários com alternativas na gestão das pressões e perdas de carga do fornecimento de água à população.
Características agronômicas de híbridos de milho silageiros cultivados na região sul de Rondônia
Authors: Brito André de Assis , Silveira Murilo Vargas da , Aráujo Érica de Oliveira , Silva Jhonathann Willian Furquin da
Published: December 2024

O principal desafio na recomendação de cultivares é o comportamento diferente dos genótipos em diferentes locais, devido à interação genótipo × ambiente. Neste sentido, o presente trabalho teve por objetivo avaliar as características agronômicas de vinte e oito híbridos de milho, visando o aprofundamento do processo tecnológico, a maximização da eficiência e rentabilidade da produção de silagem na região sul de Rondônia. na safra 2022/23 na área experimental do Instituto Federal de Rondônia, Campus Colorado do Oeste em delineamento de blocos casualizados, constituídos por vinte e oito híbridos de milho e três repetições. Após todas as avaliações, e os dados serem submetidos a análise de variância e teste de agrupamento detectou-se variações quanto ao desempenho agronômico dos diferentes híbridos de milho, no qual os materiais HLX2128, BM163PRO4, HLX2277, HL2065PRO2, HLX2104PRO2, HLX2162 e HLX2279 destacaram-se em potencial produtivo, tornando-os escolhas promissoras para produção de silagem na região sul de Rondônia; enquanto que os híbridos de milho SHS7970PRO3, LG36790PRO3 e HLSP2301PRO3 apresentaram as maiores estimativas de produtividade de grãos, na ordem de 14136,81 kg/ha, 13022,13 kg/ha e 12255,37 kg/ha, respectivamente.
Prevalence of pathologies at the epididymal level with congenital and acquired problems in alpacas
Authors: Velasquez Victor Cesar Medina , Aduviri Wilebaldo Blair Ticona , Yalli Rosita Torres , Humpire Karina Xiomara Torres , Lacuta Thania Lucero Choque , Huaman Yordi Ramos , Mamani Wagner Lucio Mamani , Llacta Carlos Joshin Ccasani
Published: December 2024

In a study carried out at the Pathology Laboratory of the Faculty of Veterinary Medicine and Zootechnics of the Universidad Nacional del Altiplano, located at 3,825 m.a.s.l. in the Puno region, histopathological lesions of the epididymis were investigated in male alpacas from the La Raya CIP. Out of a total of 128 animals, 40 animals with a positive clinical diagnosis were selected. The prevalence and characteristics of the epididymal lesions were determined using the Tru-Cut biopsy, paraffin and hematoxylin and eosin staining techniques. The results showed an overall prevalence of 31.25%, with a higher incidence in adult alpacas (21.88%) compared to young alpacas (9.37%), differences which were statistically significant (P ≤ 0.05). Among the most frequent histopathological lesions, tubular and peritubular fibrosis (25%), hypoplasia (22.5%), atrophy (12.5%), cysts (10%), chronic non-specific epididymitis (7.5%), granulomas (5%), chronic non-suppurative epididymitis (4.69%) and aplasia (2.5%) were identified. Congenital alterations included hypoplasia and aplasia, while acquired alterations included tubular and peritubular fibrosis, cysts, chronic epididymitis (specific and non-specific) and atrophy, with tubular and peritubular fibrosis being the most frequent lesion in the study. These findings provide a better understanding of epididymal pathologies in alpacas, highlighting the importance of early detection and management to improve the reproductive health of this species.
Waste management practices: evaluating the knowledge and attitudes of healthcare workers in a 120-bed hospital, Mecheria City, Southwestern Algeria
Authors: Okkacha Youb , Bouarfa Said , Amara Khaled
Published: December 2024

This study investigates the generation and management of healthcare waste at the Chnafa Brothers Public Hospital in Mecheria, located in southwestern Algeria, over a seven-month period. It highlights current practices and identifies critical deficiencies in the hospital's waste management protocols. Both quantitative and qualitative data were collected on the production of infectious healthcare waste, emphasizing the hospital's waste management practices. Analysis of waste production data and review of hospital staff practices were conducted to assess compliance with existing waste management protocols.
The findings reveal that infectious waste constitutes a significant portion of the hospital's biomedical waste, averaging 34.36 tons annually. A majority of the surveyed staff (94.44%) believe that healthcare waste exposes healthcare personnel to various health risks, with infectious risks being the most significant (95.56%), followed by chemical, biological, and psycho-emotional risks. Although 87.77% of the staff reported that waste collection is regular, 91.11% were unaware of the proper duration for waste storage prior to treatment. Considerable deficiencies were also observed in sorting and collection practices. Furthermore, 90% of the staff believe that healthcare waste is properly sorted, while 4.44% disagree and 5.56% are unsure whether sorting is adequately performed.
The hospital primarily relies on incineration to manage healthcare waste, which effectively reduces waste volume but raises environmental concerns due to pollution. Improving waste management practices and increasing staff awareness of the risks and regulations surrounding healthcare waste are crucial for enhancing public health and environmental outcomes.
Composição do leite de vacas crioulas de origem patagônica. Resultados preliminares
Authors: Fránciga Gonzalo Gastón , Benavídez Carlos , Borches Axel , López Gustavo , Martínez Ruben Darío
Published: December 2024

Las primeras vacas lecheras argentinas fueron de raza criolla. Se distribuyeron en todas las provincias, aportando leche para consumo directo y materia prima para manteca, dulce de leche y quesos regionales. Con la importación de razas lecheras especializadas a fines del siglo XIX, perdieron protagonismo como lecheras. La Facultad de Ciencias Agrarias de la UNLZ, posee un plantel de bovinos criollos de origen patagónico, procedentes del Parque Nacional Los Glaciares, que ha evolucionado en condiciones de asilvestramiento y se adaptó a un clima frío y húmedo. No encontramos ningún trabajo que describa la composicion láctea de las vacas de nuestra raza pionera. Se ordeñaron seis vacas criollas de origen patagónico de cinco años de edad promedio y dos vacas Holando Argentino como testigos. Durante el ordeñe se mantuvieron sobre un  pastizal natural serrano en la escuela agropecuaria Nro 1 de Tornquist. Al cuarto día postparto los terneros se destetaron. Las vacas se ordeñaron diariamente en tambo mecánico en horas del mediodía, suministrándoles a cada vaca durante el ordeñe 2,35 kg de suplemento alimentario. El control lechero regional, tomó muestras de leche de las ocho vacas, siendo analizadas en el laboratorio Lacle, utilizando los procedimientos habituales. Los resultados promedios expresados en gr/100ml para las vacas Criollas y para la Holando Argentino fueron respectivamente: Grasa: 0,94 y 2,76. Proteína: 7,38 y 5,43. Lactosa: 1,19 y 3,93. Sólidos Totales: 8,56 y 12,65. Sólidos No Grasos: 8,12 y 9,89. En promedio las Criollas patagónicas mostraron mayor porcentaje de proteína y menor grasa y lactosa.
Fisiopatología, evaluación y estrategias terapéuticas de la cistitis intersticial, una causa de dolor pélvico crónico
Authors: Enríquez Enríquez Maritza Johanna
Published: December 2024

La cistitis intersticial es un síndrome clínico, que forma parte de un motivo de consulta muchas veces infradiagnosticado y que afecta en su mayoría al sexo femenino, con etiología poco clara. Es un padecimiento de curso crónico caracterizado por el dolor pélvico en asociación de sintomatología urinaria, su diagnóstico se basa en la clínica y descarte de otras patologías. El tratamiento se encamina al control de los síntomas y mejora de la calidad de vida del paciente, quedando las opciones quirúrgicas como alternativas cuando las medidas terapéuticas iniciales han fracasado. Comúnmente diagnosticada de manera errónea debido a la heterogeneidad de su sintomatología, diversa conceptualización y fisiopatología compleja, la determinación clínica temprana de la cistitis intersticial permite un abordaje efectivo de la patología, permitiendo un óptimo control de la sintomatología, carga emocional y calidad de vida del paciente.
Socket Shield Technique in Immediate Implantation of the Maxillary Lateral Incisor. Clinical Case
Authors: Huseynli R.A. , Panahov N.A.
Published: December 2024

Alveolar bone resorption is a natural process that occurs over time after tooth extraction, and is a challenge for implant treatment, complicating the process of prosthetic rehabilitation. That is why methods of immediate implant placement, while maintaining the anatomical parameters of the socket, are very popular these days. With this method of treatment, a reduction in dimensional changes associated with extraction is achieved. One of these methods is the Socket Shield Technique (SST). This is an effective way to preserve the anatomical contour of the alveolar ridge, improving aesthetic results. Another very important advantage of this technique is the fact that even with a thickness of less than 1 mm. buccal bone, the anatomical parameters of the socket can be preserved for many years. This case report presents a 22-year-old female patient with a fractured upper lateral incisor. The socket shield technique was chosen based on the clinical findings from the cone beam computed tomography (CBCT) scan. The temporary restoration was provided immediately to preserve soft tissue integration. A 3 years clinical observations, suggests that the socket shield technique is a useful method for preserving hard and soft tissue structures, thereby improving aesthetic outcomes.

Резорбция альвеолярной кости – естественный процесс, который происходит с течением времени после удаления зуба и является проблемой для имплантологического лечения, усложняя процесс протезной реабилитации. Вот почему методы немедленной установки имплантатов с сохранением анатомических параметров лунки очень популярны в наши дни. При таком методе лечения достигается уменьшение размерных изменений, связанных с удалением. Одним из таких методов является техника Socket Shield. Это эффективный способ сохранения анатомического контура альвеолярного гребня, улучшающий эстетические результаты. Еще одним очень важным преимуществом этой техники является тот факт, что даже при толщине менее 1 мм щечной кости анатомические параметры лунки могут сохраняться в течение многих лет. В статье представлен клинический случай наблюдения 22-летней пациентки с переломом верхнего бокового резца. Методика Socket Shield была выбрана на основе клинических результатов сканирования с помощью конусно-лучевой компьютерной томографии. Временная реставрация была выполнена немедленно для сохранения интеграции мягких тканей. Клинические наблюдения в течение 3 лет показывают, что метод Socket Shield является полезным для сохранения твердых и мягких тканей, тем самым улучшая эстетические результаты.
Marketing strategies of MIPyMES in the Cd. Mexico and metropolitan area during and after the pandemic
Authors: Álvarez-García Mónica , Gutiérrez-Zepeda Martha del Pilar , Guerrero-Ibarra Carlos , Waldo Caamaño José David
Published: December 2024

In MIPyMES, it was a problem to withstand market irregularities and maintain themselves during the pandemic (SARCOV-2). Companies began using digital marketing to market, and after four years, they must carry out strategies for online and direct sales. This research aims to know the opinion of 110 companies that previously underwent a study on the marketing strategies used during the pandemic and then through a comparison. The research results show that during the pandemic, social networks were used for sales and promoted products with discounts and home deliveries, yet direct sales, deals, demonstrations, and printed advertising continued to be the most used and have greater results. Digital marketing has grown enormously, and MIPyMES must venture into it to continue competing in the market.
The Living Document: Medical Records as a Malleable Presence
Authors: Lyckblad Camilla
Published: December 2024

Understanding why individuals might safeguard information or keep secrets in working documents such as medical records is essential for the development of good quality care, fostering an environment where both patients and staff feel secure to part with sensitive information, encouraging more honest and open communication as well as improved quality of care. This ongoing research aims to deepen comprehension of information behavior in clinical contexts, where the contemporary medical record, with its increasing properties such as open record access for patients, can be viewed as an entity that both listens and influences. This examination sheds light on the complex dynamics of truth within clinical environments, where patients and health care professionals, due to a continuously evolving document, might selectively disclose or withhold information, aiming to safeguard themselves. Fifteen informant interviews among Swedish clinicians in pediatric psychiatry concerning the impact of open record access reveal that the contemporary medical record takes on a form reminiscent of a malleable presence, embodying qualities of a sentient being within the treatment space. Findings in the study shed light on the intricate mechanisms through which the protection of both information, patient, and clinician, intertwine with the contemporary medical record as an entity of great agency.
Relevance, Works and Context Engineering
Authors: Buckland Michael , de Fremery Wayne
Published: December 2024

Relevance is regarded as centrally important in documentation and information science but has resisted satisfactory definition. The literature presents vague, subjective descriptions and/or operational definitions based on untenable theoretical assumptions. The “work” is a similarly central and poorly defined concept in bibliographic theory and cataloguing. This short essay summarizes previous scholarship that reformulates concepts of relevance in information science as functions of use and works in bibliographic theory as useful sets of objects. Conceptual utility in both cataloging theory and information science is sought by developing descriptive models that attend to the positionality and temporality of “works” and “relevance” as they have been reformulated by de Fremery and Buckland (2023, 2024). Importantly, the descriptive models suggests the importance of context in formulations of relevance as a function of use and works as useful sets of objects. It concludes by suggesting that bibliographies, library catalogs, search engines and retrieval systems can be considered context engineering systems, thereby productively reorienting the discourse about these documentary technologies to suggest the important role these systems play in formulating contexts in addition to existing in or describing contexts.Relevance is regarded as centrally important in documentation and information science but has resisted satisfactory definition. The literature presents vague, subjective descriptions and/or operational definitions based on untenable theoretical assumptions. The “work” is a similarly central and poorly defined concept in bibliographic theory and cataloguing. This short essay summarizes previous scholarship that reformulates concepts of relevance in information science as functions of use and works in bibliographic theory as useful sets of objects. Conceptual utility in both cataloging theory and information science is sought by developing descriptive models that attend to the positionality and temporality of “works” and “relevance” as they have been reformulated by de Fremery and Buckland (2023, 2024). Importantly, the descriptive models suggests the importance of context in formulations of relevance as a function of use and works as useful sets of objects. It concludes by suggesting that bibliographies, library catalogs, search engines and retrieval systems can be considered context engineering systems, thereby productively reorienting the discourse about these documentary technologies to suggest the important role these systems play in formulating contexts in addition to existing in or describing contexts.
The collective safeguarding responsibility model: The 12Cs: Development, evidence base and potential application
Authors: Ball Emma Jayne
Published: December 2024

Multi-agency (also referred to as inter-professional/inter-agency) collaboration is viewed as an imperative way of working to prevent and protect people from harm. The operationalization of multi-agency safeguarding, including the implementation of legislation and guidance, varies widely and there remain areas of ongoing learning in multi-agency safeguarding enactment. In addition to understanding the facilitators of collaborative safeguarding, we must also have tools to evaluate and scrutinize these arrangements, to maximize our effectiveness. This article follows on from a previous article (Ball et al., 2024a) and introduces the collective safeguarding responsibility model: the 12Cs. The 12Cs provides a unique, evidence-based, holistic framework that can demonstrate how safeguarding arrangements are working strategically and operationally, across and within organizations. The framework focuses on the role of practitioners and agencies in responding to safeguarding concerns, and crucially, the framework incorporates understanding the perspectives of those with lived experiences of receiving safeguarding support. The 12Cs can provide both a local and national understanding of what we have in place regarding multi-agency safeguarding. It also explores how this works, whether it is effective and what action is required to improve responses going forward. The multi-agency safeguarding landscape is a dynamic space, and as such, we must be able to continually assess and be assured of our safeguarding effectiveness to provide a robust evidence base to inform future practice.
Emancipación, autoridad y autonomía en la era de la libertad
Authors:   , Marín Arias Nancy Faneyra
Published: December 2024

El mundo moderno trae consigo retos y nuevas formas de entender lo educativo desde las cuales se hace necesario repensar las formas en las que se relacionan y configuran la autoridad pedagógica y las posibilidades de emancipación de los sujetos. Con esta óptica, el presente trabajo final de Maestría en Educación presenta un breve análisis y reflexión frente a los roles y posiciones que asume la autoridad, la emancipación y la autonomía dentro de los fenómenos que plantea la cultura actual. En este breve esbozo, se apela a un diálogo abierto con la tradición filosófico-pedagógica desde el cual se busca comprender las transformaciones y dinámicas que mueven a dichos actores y conceptos en la educación contemporánea.
Appréciation du caractère proportionné (ou non) de la destruction d’un ouvrage contesté
Authors: Milleville Sébastien
Published: December 2024

CA Grenoble, 1re chambre, 20 février 2024 Selon l’expert judiciaire, le mur litigieux est exempt de toute malfaçon de nature à en fragiliser la construction et à représenter un danger pour les personnes ou pour les biens. La cause du trouble anormal de voisinage occasionné par son existence réside dans son aspect esthétique, il y a lieu d’infirmer le jugement déféré en ce qu’il a ordonné la démolition de cet ouvrage, ce mode de réparation s’avérant être disproportionné. CA Grenoble, 1re chambre, 28 mai 2024La construction nouvelle du chalet de 80 m2 édifiée sans permis de construire au regard de son refus du 19 avril 2021 est illicite et la commune de [Localité 5] est fondée à en demander la démolition. Pour s’opposer à cette démolition, les époux [N] font valoir l’atteinte disproportionnée au droit au domicile et au droit à la vie familiale visés dans l’article 8 de la convention de sauvegarde des droits de l’homme et des libertés. Toutefois, alors qu’il est établi que les époux [N] sont domiciliés sur la commune de [Localité 6], il n’est justifié d’aucune atteinte disproportionnée à un domicile et une vie familiale qui n’existent pas sur la commune de [Localité 5] alors qu’est en jeu la protection de la vie humaine au regard des risques d’inondation.
Compétence du président de chambre pour prononcer l’irrecevabilité de l’appel : c’est oui ou bien c’est non ?
Authors: Vigouroux Naomi
Published: December 2024

En vertu de l’article 905‑2 ancien du Code de procédure civile, l’irrecevabilité de l’appel tirée de sa tardiveté ne peut être prononcée par le président de chambre dans une procédure à bref délai. Cette interprétation du texte a pris fin le 1er septembre 2024 du fait de l’entrée en vigueur du décret de simplification du 29 décembre 2023. Toutefois, l’arrêt rendu le 16 janvier 2024 conserve un intérêt en ce qu’il estime que l’extension de la compétence du président nuit à la célérité et l’efficacité de la procédure à bref délai. Or, le nouvel article 906‑3 étend les pouvoirs du président.
L’interpellation et le menottage du suspect n’imposent pas nécessairement son placement immédiat en garde à vue
Authors: Ratineau Yannick
Published: December 2024

Il résulte des articles 803 et 73 du Code de procédure pénale que le menottage d’un suspect réalisé dans le cadre du maintien de l’ordre public‚ et dans l’attente de l’arrivée des pompiers‚ afin de protéger les personnes et les biens de son comportement dangereux‚ pour lui‑même et pour autrui‚ au regard de son état, et non pas dans le but d’être présenté devant un officier de police judiciaire‚ n’impose pas son placement en garde à vue.
Peran Love Of Money, Machiavellian, Narsisme, Dan Religiusitas Terhadap Persepsi Etis Mahasiswa Akuntansi
Authors: Ramadhan Bilal Achmad Zaki , Wardani Marita Kusuma
Published: December 2024

This research aims to examine the influence of love of money, machiavellianism, narcissism, and religiosity on accounting students’ ethical perception. The data used primari data. The metode used is multiple linear regression analysis. The population in this study were accounting and sharia accounting student at universities in the Kartasura area, Sukoharjo, Central Java. The sample collection technique used in this research was cluster sampling and 191 sample data were obtained using the criteria of accounting students who had taken auditing courses. The result of this study shows that Machiavellianism variabel has a positive effect on accounting students’ perceptions of unethicality, because the statements used to build respondents’s perceptions use negative cases. Meanwhile, love of money, narcissism and religiosity have no effect on accounting students’ ethical perceptions. The contribution of this research further ecncourages the need to emphasize learning ethical values in every course, especially in the accounting study program to shape the ethical behavior of accounting students.
Preparation and Evaluation of Delayed Release Pantoprazole Sodium Enteric Coated Pellets
Authors: Divyasree Varasala , Rani Dr. Shobha , Reddy Dr. M. Sunitha , Vijetha Dr. K. Anje , Dr. B. Gavaskar Dr. B. Gavaskar
Published: December 2024

The goal of this study was to
develop a stable, cost-effective, and higher-quality
enteric-coated pantoprazole pellet formulation for
the treatment of gastro-esophageal reflux disease
(GERD). Although pantoprazole and other proton
pump inhibitors are effective in treating acidrelated diseases, they become unstable in acidic
environments. Delay-release formulations are
therefore essential to ensuring the efficacy of
treatment. Nine different formulations are made
using different enteric polymers. Using the
solution-suspension layering approach, the
formulation process was completed in FBC and
compared to the commercial dosage form. Acidlabile drugs such as pantoprazole can be prevented
from being broken down by the stomach by the
polymers Eudragit L 30 D 55 and Eudragit L 100-
55. Rather, the polymers enable the drug to be
released into the more neutral pH of the intestine
while staying intact in acidic environments. It was
revealed by FT-IR research that the medication and
polymers got along. With regard to GERD
treatment, Formulation F9, which has a particular
remark, demonstrated the highest drug release
(98%) in phosphate buffer at pH 6.8. Patients with
GERD benefit from improved medication stability
and effective delivery to the intestinal site of action
thanks to this formulation strategy.
Effect of Manganese in Teratospermia and Oligospermia
Authors: Dr. Lokesh. K Dr. Lokesh. K , Purushothaman Dr. Borus , Xavier Dr.YashmiAgwina , Veerammal Veerammal , Sharma Dr. Suman
Published: December 2024

Manganese (Mn) is an essential trace element
involved in numerous physiological processes,
including antioxidant defense and metabolism.
However, emerging research suggests that
abnormal levels of manganese may contribute to
male infertility disorders, such as teratospermia
(abnormal sperm morphology) and oligospermia
(low sperm count). While manganese plays a
crucial role in the function of antioxidant enzymes
that protect sperm cells from oxidative damage,
excessive or deficient Mn levels have been
associated with compromised sperm quality. In
cases of teratospermia, elevated manganese
exposure has been linked to increased
morphological abnormalities in sperm, potentially
due to oxidative stress and disruptions in cellular
signaling pathways. In oligospermia, altered
manganese levels may impact spermatogenesis,
leading to reduced sperm production. This review
synthesizes recent findings on the relationship
between manganese exposure and male infertility,
emphasizing the mechanistic insights into how
manganese dysregulation may exacerbate
conditions like teratospermia and oligospermia.
Improved understanding of manganese’s role could
support targeted strategies to mitigate manganeserelated reproductive toxicity and improve fertility
outcomes in affected individuals.
Formulation and Evaluation of Anti-Acne Liquid Plaster
Authors: Jilsha G Jilsha G , Anjali G Anjali G , Roy Jincy , Roy Risna C , Mumthas Shana
Published: December 2024

More than 85% of young people worldwide suffer
from acne vulgaris, a prevalent chronic
inflammatory skin condition characterized by red
pimples, especially on the face, caused by inflamed
or infected sebaceous glands. It is most common
among teenagers and young adults, often affecting
their self-esteem and appearance. While modern
treatment options are available, herbal remedies are
increasingly popular due to their reduced side
effects and growing demand in the global market.
Neem and guava leaves are rich in secondary
metabolites such as flavonoids, saponins, alkaloids,
and tannins, which have antibacterial properties.
This study aims to formulate a herbal liquid plaster
using ethanolic extracts of neem and guava leaves
combined with polyvinyl butyral polymer and
evaluate its physical characteristics. Liquid plaster,
a modern and innovative approach, acts as an
adhesive with antibacterial agents that dry to form a
protective film. The liquid plaster is prepared by
heating at 70°C to create a flexible polymer. The
anti-acne liquid plaster formulations, prepared with
varying quantities of polymer, solvent, thickening
agent, and different ratios of neem and guava leaf
extracts (F1: 1 ml:1 ml, F2: 1 ml:2 ml, F3: 1 ml:1
ml, F4: 1 ml:2 ml, F5: 1 ml:1 ml, F6: 1 ml:2 ml),
were evaluated for physical characteristics such as
color, consistency, appearance, pH, spreadability,
viscosity, and drying time. Among these, F2 and F5
exhibited favorable results. Antimicrobial studies
against *S. aureus* and *E. coli* were conducted
using clindamycin as the standard. The results
showed that F2 had a 41 mm zone of inhibition
against *S. aureus*, nearly matching the standard
inhibition zone of 45 mm. Although
*Propionibacterium* plays a key role in acne
development, *S. aureus* colonization is also
prevalent in one-third to one-half of acne cases.
Therefore, neem (*Azadirachta indica*) and guava
(*Psidium guajava*) liquid plaster presents a novel
anti-acne solution. While many herbal anti-acne
formulations exist in the market, this innovative
formulation, incorporating some safe synthetic
ingredients, provides an effective alternative to
acne patches, offering a transparent, subtle, and less
noticeable treatment.
Hyperlipidemia and its treatment
Authors: Mr. Anil M Mr. Anil M , Rajashekhar Mr. U
Published: December 2024

Hyperlipidemia is characterised by
elevated concentrations of one or more plasma
lipids, including low-density and Exceptionally low
concentration lipoproteins, phospholipids,
triglycerides, cholesterol and increasedelevated
high-density lipoprotein values. The increase in
lipoprotein levels is a prominent hazard component
associated withheart conditions. Mainly two forms
of hyperlipidemia exist. Primary hyperlipidemia,
which is typically hereditary and results from
genetic abnormalities, is the initial form. Secondary
hyperlipidemia is an alternative form that arises
from predisposing factors such as chronic renal
failure, obesity, thyroid dysfunction, intoxication,
or hypothyroidism. As a second-line treatment,
PCSK9 inhibitors are presently administered to
patients whose lipid levels are unregulated despite
treatment with statins or statin combinations.
Evinacumab and other ANGPTL3 inhibitors have
received clearance from the FDA and the EMA to
treat familial hypercholesterolemia. This article
serves as a concise overview of novel agents
presently in use or under development for the
purpose of lowering lipid levels. The primary
objective of this research endeavour is to ascertain
potential therapeutic targets for hyperlipidemia and
establish a correlation between the clinical
presentation of hyperlipidemia and the most recent
advancements in this rapidly expanding discipline.
Additionally, the role of nutraceuticals in
hyperlipidemia treatment is discussed.
ECONOMÍA SOCIAL Y SOLIDARIA EN URUGUAY: MAPEO CUANTITATIVO
Authors: Rieiro Castiñeira Anabel , De Giacomi Brisa , Pena Daniel
Published: December 2024

El objetivo del trabajo es presentar los datos del mapeo cuantitativo sobre las distintas experiencias que conforman el campo de la Economía Social y Solidaria (ESS) en el Uruguay contemporáneo. Se discute y define conceptualmente la diferencia entre “la economía” y “lo económico”, buscando una mirada teórica que permita comprender las experiencias de solidaridad económica estudiadas. Metodológicamente, se recurre a la sistematización, actualización y generación de nueva información a partir de encuestas, lo que se complementa con entrevistas semiestructuradas realizadas a organizaciones de representación y articulación de segundo y tercer grado. Los resultados empíricos muestran la relevancia del sector de la ESS, así como la heterogeneidad de las experiencias y tramas organizativas que lo conforman. Por un lado, encontramos un subsector de Economía Social conformado por el movimiento cooperativo. Este ha ido consolidándose durante más de un siglo, contando con más de un millón de integrantes-socios, que conforman cerca de dos mil cooperativas. Las mismas se articulan en una decena de federaciones según su modalidad y, junto a otras organizaciones, constituyen una Confederación, y cogestionan la política pública desde el Instituto Nacional de Cooperativismo. Por otro lado, encontramos un subsector de Economía Solidaria mucho más heterogéneo en sus formas de organización. Se estima que cuenta con al menos trece mil integrantes-socios y al menos mil colectivos articulados en una veintena de redes, coordinadoras, comisiones, ferias, espacios de trueque e intercambios. Trascendiendo la magnitud del fenómeno, demostrada empíricamente, las experiencias mapeadas permiten repensar nuestras configuraciones socioeconómicas más allá del mercado.
EVIDENCIAS DEL PRINCIPIO DE INTERCOOPERACIÓN EN EL SECTOR ENERGÉTICO. COMUNIDADES ENERGÉTICAS BAJO LA FORMA JURÍDICA DE COOPERATIVAS DE INTERÉS PÚBLICO
Authors: Vaño Vaño María José , Meira Deolinda
Published: December 2024

Las comunidades energéticas se consideran a escala europea la piedra angular para fomentar el autoconsumo, reducir la pobreza y lograr beneficios medioambientales, económicos y sociales para sus miembros y comunidades. Las comunidades energéticas pueden adoptar la forma bien de energías renovables o bien de ciudadanos y en sus Directivas reguladoras se hace especial hincapié en la importancia de desarrollar alianzas entre el sector público y privado. Estas colaboraciones público-privadas, cuando implican a cooperativas y organismos públicos, en el contexto de una entidad con forma jurídica de cooperativa, son una manifestación del principio cooperativo de intercooperación. Tanto en España como en Portugal, las entidades públicas, especialmente los ayuntamientos, pueden ser miembros de una comunidad energética, siendo en este caso la cooperativa de interés público la forma jurídica más adecuada para enmarcar esta relación público-privada.
ASMENŲ, AUGINANČIŲ IKI 2 METŲ VAIKUS, FIZINIO AKTYVUMO, PSICHOEMOCINĖS SVEIKATOS IR GYVENIMO KOKYBĖS VERTINIMAS
Authors: Seibutytė Gabija , Borkertienė Vaida , Gintilienė Milda
Published: December 2024

Fizinis aktyvumas apima įvairią veiklą, kurios metu ju­dinamas kūnas ir naudojama energija. Svarbu įvertinti tėvų fizinį aktyvumą po vaiko gimimo, nes jis gali turėti tiesioginės įtakos jų sveikatai. Fizinis aktyvumas teigia­mai veikia tėvų psichinę sveikatą, padeda mažinti stresą ir gerina nuotaiką, o tai gali padėti jiems įveikti tėvystės iššūkius. Todėl labai svarbu nustatyti fizinio aktyvumo lygį ir jo ryšį su tėvų psichoemocine būsena, stresu ir bendra gyvenimo kokybe. Tyrimo problema: koks as­menų, auginančių iki 2 metų vaikus, fizinis aktyvumas, psichoemocinė sveikata ir gyvenimo kokybė?

Tyrimo tikslas − nustatyti asmenų, auginančių iki 2 metų vaikus, fizinį aktyvumą, psichoemocinę sveikatą ir gy­venimo kokybę. Tyrimo uždaviniai: 1. Įvertinti asmenų, auginančių iki 2 metų vaikus, fizinį aktyvumą. 2. Įvertinti asmenų, auginančių iki 2 metų vaikus, psichoemocinę sveikatą. 3. Įvertinti asmenų, auginančių iki 2 metų vai­kus, gyvenimo kokybę.

Tyrimo metodai: mokslinės literatūros analizė, kiekybinis tyrimas − apklausa, naudojantis vertinimo klausimynais bei kiekybinė duomenų analizė, analizuojant tyrimo metu gautus rezultatus. Vertinimas: fizinis aktyvumas klau­simynu (IPAQ trumpoji lietuviška versija), gyvenimo kokybė klausimynu (gyvenimo kokybės SF-36 klausi­mynas) bei stresas (PSS skale).

Išvados. Asmenų, auginančių iki 2 metų vaikus, fizinis aktyvumas buvo žemas arba vidutinio lygio. Aukštą fi­zinio aktyvumo lygį nurodė mažiau nei trečdalis tyrime dalyvavusių asmenų. Asmenys, auginantys iki 2 metų vaikus, dažniausiai nurodė vidutinį, trečdalis – aukštą streso lygį. Asmenys, auginantys iki 2 metų vaikus, savo gyvenimo kokybę vertina kaip gerą.
MALTOS MĖSOS MIKROBINĖS TARŠOS VERTINIMAS
Authors: Maželienė Žaneta , Aleksandravičienė Asta , Viliušienė Ingrida
Published: December 2024

Mėsa turi didelę maistinę vertę, tačiau termiškai neap­dorotos mėsos vartojimas, netinkamos laikymo sąlygos ir higienos reikalavimų nesilaikymas gali sukelti rimtas sveikatos problemas. Todėl itin svarbu laikytis higienos reikalavimų visuose procesuose – nuo gyvulio skerdimo iki mėsos pateikimo vartotojui („nuo tvarto iki stalo“). Mėsos pH, maistinė vertė ir cheminė sudėtis sukuria ide­alias sąlygas bakterijų dauginimuisi. Dėl to, netinkamai tvarkant ar nepakankamai termiškai apdorojant mėsą, padidėja rizika susirgti zoonozinėmis ligomis, tokiomis kaip ešerichiozė ar salmoneliozė.

Tyrimo tikslas – įvertinti žalios maltos jautienos, vištie­nos ir kiaulienos mikrobinį užterštumą.

Tyrimo metodika. Tyrime atlikti kiekybiniai mikrobiolo­giniai tyrimai siekiant nustatyti bendrą mikrobinį užterš­tumą ir aptikti bakterijas Salmonella spp. ir Escherichia coli. Buvo analizuoti 48 termiškai neapdorotos vištie­nos, kiaulienos ir jautienos mėginiai, surinkti iš Kauno miesto turgaviečių, remiantis LST EN ISO 6579-1:2017, LST EN ISO 6579-1:2017/A1:2020 ir LST ISO 16649- 2:2002 standartais. Duomenų analizė atlikta naudojant aprašomąją statistiką, o duomenys apdoroti Microsoft Excel 2019 programa.

Tyrimo rezultatai. Tyrimo rezultatai parodė, kad visuose tirtuose mėginiuose buvo aptikta E.coli bakterijų, o 14 proc. mėginių buvo užteršti Salmonella spp. bakterijomis. Tai rodo, kad turgavietėse parduodama termiškai neap­dorota malta mėsa kelia rimtą pavojų vartotojų sveikatai ir nėra tinkama vartoti neatlikus papildomo apdorojimo.

Išvados. E. coli buvo aptikta visuose maltos mėsos mė­giniuose iš Kauno turgaviečių, o Salmonella spp. dau­giausia buvo nustatyta maltos vištienos mėginiuose (25 proc.), maltos kiaulienos mėginiuose –13 proc., maltos jautienos – 6 procentai.
RISK STRATIFICATION OF IN-HOSPITAL MORTALITY IN PATIENTS WITH HIGH-RISK PULMONARY EMBOLISM
Authors: Tseluyko V.I. , Yakovleva L.M. , Mishchuk N.E. , Kurinna M.V. , Kharchenko L.V. , Askierov R.N. , Shylo N.G.
Published: December 2024

Objective. To identify factors associated with in-hospi­tal mortality and to develop and validate a formula for additional risk of early mortality in patients (pts) with high-risk pulmonary embolism (PE).

Materials and Methods. The study consisted of two pha­ses. In Phase I, a retrospective analysis was conducted on the medical records of 113 pts with high-risk PE who were consecutively hospitalized at Kharkiv City Clini­cal Hospital No. 8 from 01.01. 2017 to 01.01.2023. The mean age of pts was 65.14±14.13 years, with 45 (38.8%) males and 68 (60.2%) females. Based on the course of the disease, the pts were divided into two groups: Group 1 – 63 pts (55.8%) who improved and were discharged, and Group 2 – 50 pts (44.2%) who died during hospi­talization. Phase II of the study involved a multicenter cohort (9 centers in Ukraine that provided data on pts with high-risk pulmonary embolism hospitalized from January 2023 to December 2023). This phase included 75 pts with high-risk PE, with mean age of 60.60±13.40 ye­ars; 38 (50.7%) were male, and 37 (49.3%) were female. Group I consisted of 65 patients (80%) discharged with improvement, Group II comprised 15 patients (20%) who died during hospitalization. Clinical and anamnestic and laboratory-instrumental data were analyzed, statistical analysis of the resulting figures was performed.

Results and Discussion. In Phase I of the study, a formula for additional risk stratification of early mortality in pts with high-risk PE was developed. Using ROC analysis, the sensitivity of the resulting prognostic formula was found to be 64.0%, and the specificity was 92.1%. Ba­sed on this formula, we proposed a simplified scale cal­led SBAFS (S – saturation, B – bifurcation, A – arterial hypotension, F – fraction of ejection, S – female sex). In Phase II of the study, the sensitivity and specificity of the obtained formula were validated using ROC analy­sis: the sensitivity was 93.3%, and the specificity was 74.6%, confirming the results of Phase I. When evalua­ting the proposed simplified SBAFS scale, it was also found that in patients of Group II, the mean score on the scale was (2.53±0.83) and was higher than that in Group I: (1.57±0.96), p=0.0006.

Conclusions. The main factors associated with the risk of in-hospital mortality in pts with high-risk PE are de­creased oxygen saturation, thrombus localization in the bifurcation of the pulmonary artery as determined by СТPA angiography, arterial hypotension, female sex, and decreased left ventricular ejection fraction as assessed by echocardiography. The previously proposed SBAFS formula confirmed its significance upon validation in­volving data on PE pts from 9 regions of Ukraine, with a sensitivity of 93% and specificity of 75%.
KINEZITERAPIJOS POVEIKIS NĖŠČIŲJŲ MIEGO KOKYBEI, NUOVARGIO IR SKAUSMO MAŽINIMUI
Authors: Mažeikė Ligita , Peregorodejevaitė Vesta
Published: December 2024

Nėštumo metu maždaug 50 proc. moterų patiria juosmens ir/ar dubens skausmą, prastėja miego kokybė, trumpėja miego trukmė, ypač vėlyvuoju nėštumo laikotarpiu. Nėš­tumo metu atliekama fizinė veikla gali turėti teigiamos įtakos nėščiųjų skausmo mažinimui, padėti kovoti su nėš­tumo sukeltu nuovargiu ir pagerinti miego kokybę, tačiau dar nėra aišku, kokį poveikį nuotoliniu būdu atliekami kineziterapiniai pratimai turės nėščiųjų miego kokybei, nuovargiui ir skausmui.

Tyrimo tikslas − nustatyti kineziterapijos poveikį nėš­čiųjų miego kokybei, nuovargio ir skausmo mažinimui.

Tyrimo metodai. Tyrime dalyvavo 20 moterų, 28,2 ± 3,9 metų amžiaus, besilaukiančių 27,0 ± 2,6 savaites (ty­rimo pradžioje), kurios atsitiktiniu būdu buvo padalintos į dvi grupes: tiriamąją (n = 10) ir kontrolinę (n = 10). Tiriamoji grupė 6 savaites, 3 kartus per savaitę, atliko kineziterapinę mankštą, o kontrolinė grupė gyveno įpras­tiniu ritmu. Tyrimo pradžioje ir po 6 savaičių tiriamųjų miego kokybė buvo vertinama Pitsburgo miego kokybės indeksu, nuovargis buvo vertinamas Daugiamačiu nuo­vargio inventoriumi, skausmas – Dubens srities skausmo klausimynu.

Rezultatai. Po 6 savaites taikytos kineziterapinės mankš­tos pagerėjo nėščiųjų miego kokybė (p<0,05), fizinis aktyvumas (p<0,05) ir motyvacija (p<0,05), sumažėjo bendras nuovargis (p<0,05) ir skausmas (p<0,05). Kon­trolinėje grupėje pablogėjo miego kokybė (p<0,05), pa­didėjo skausmas (p<0,05), sumažėjo fizinis aktyvumas (p<0,05) ir motyvacija (p<0,05).

Išvados. Po kineziterapinių mankštų sumažėjo nėščiųjų bendras nuovargis ir jaučiamas skausmas, pagerėjo fizi­nis aktyvumas, motyvacija ir miego kokybė, o fizinis ir protinis nuovargis nepakito.
The role of ICT in preserving proverbs among Vhavenda communities
Authors: Nevondo Phathutshedzo Unarine , Madima Thizwilondi , Makhanikhe Justice
Published: December 2024

This study explored the role of ICT in preserving proverbs among Vhavenda communities. From time immemorial, proverbs were valuable cultural practices of oral tradition, which were used to empower the young generation on morals, norms, behaviour, education, and other African values. It has been noticed that due to modernisation and lack of preservation, proverbs have been abounded by the majority of Vhaven?a youths, which seems to be resulting in moral degeneration because youth no longer acquire moral knowledge and skills through proverbs. This study grounded by diffusion of innovation theory. This study intended to adopt a qualitative research design. Therefore, participants were selected through purposive sampling. Furthermore, semi-structured was used to collect data. Thematic data analysis was used to analyse data. The envisioned findings of the study could be convenient in preserving the Vhaven?a proverbs.
Telfairia Occidentalis as a Phytotherapeutic Agent for Chemical (Phenylhydrazine) Induced Anaemia
Authors: Onuorah Onyinyechukwu T. , Ajani Rotimi S. , Nweke Elizabeth O.
Published: December 2024

Introduction: Anaemia is a medical condition characterized by a decrease in the number of red blood cells and the amount of haemoglobin in the blood leading to inadequate oxygen delivery to tissues and organs. Telfairia occidentalis is a dietary leafy vegetable with phytochemicals that are beneficial to human health. Methodology: Anaemia was induced in rats by oral administration of phenylhydrazine and subsequently followed by administration of aqueous extract of T. occidentalis at 100mg and 200mg/kg respectively. At the expiration of the study, blood samples were taken from the animals for evaluation of red blood cell parameters. Results: The red blood cell count, packed cell volume, haemoglobin concentration, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration of the Non extract anaemic group were significantly depressed. The corresponding values for the extract groups were similar to those of the control. Conclusion: The extract of Telfairia occidentalis was able to reverse the anaemia induced by oral administration of phenylhydrazine in animal model.
ACUTE AND SUBACUTE TOXICITY OF THE PREPARATION BASED ON THE ANTIBIOTIC PAROMOMYCIN
Authors: Stybel V. , Patereha I. , Kushnir V. , Shkodyak N. , Yurynec T.
Published: December 2024

Antibiotics are currently the most common drugs widely used in veterinary medicine. The article presents the results of a study of the acute and subacute toxicity of a drug based on the antibiotic paromomycin.
                The acute toxicity parameters of the drug “Gabbrovet Multi” were studied in white rats, 2-3 months old, weighing 180-200 g. The drug was administered intragastrically, once. To determine the toxicity of the drug “Gabbrovet Multi” for white rats, doses of 1000, 3000 and 5000 mg/kg of animal body weight were taken. 6 laboratory animals were used for each dose.
                Subacute toxicity was studied on 18 white rats weighing 180-200 g. For this purpose, a control and two experimental groups of animals were formed on the principle of analogues, 6 rats each. The animals of the control group were administered water. The animals of the first experimental group were administered “Gabbrovet Multi” in a therapeutic dose of 0.05 ml per animal, the animals of the second experimental group were administered tenfold the therapeutic dose of 0.5 ml per animal. In the subacute experiment, “Gabbrovet Multi” was administered to rats for 10 days.
                As a result of acute toxicity studies, it was found that after administration of Gabbrovet Multi to white rats in various doses, all animals remained alive, actively consumed water and food. During the subacute toxicity study, no deaths of laboratory rats were observed. On the 11th day of the experiment, when the drug was administered in experimental doses, no significant changes in the mass coefficients of the liver, kidneys, heart, spleen and lungs were found compared to the control, and no significant changes in hematological blood parameters were found or noted. When studying the effect of the drug on the biochemical parameters of blood serum in animals of the experimental groups, an increase in the activity of ACE was found, indicating toxic liver damage.
                Under conditions of intragastric administration of the drug “Gabbrovet Multi” LD50 for white rats is more than 5000 mg/kg body weight. The drug belongs to low-toxic substances. The use of the drug “Gabbrovet Multi” in therapeutic and ten-fold therapeutic doses for 10 days leads to liver damage in animals of the experimental groups.