bluuebunny/crossref_metadata_2025 huggingface dataset:
Export of medical education in the university ecosystem of the Kyrgyz Republic
Authors: Lailieva Ermeka Jumakanovna , Uzakbaev Chyngyz Kamchibekovich , Turdumatova Dinara Asylbekovna
Published: July 2024

The article defines the role of export of educational services in the system of national education of the Kyrgyz Republic. The main problem in the realization of such services is the integration of foreign students into the national environment. The purpose of the study is to create a means to support such students in mastering educational programs. For this purpose, a structural analysis of the educational process was carried out to establish the key objects and related processes. A functional model is created, reflecting all aspects that influence the change of process states and transforming objects (e.g., controlling influences and mechanisms). The resulting model is the basis for the design phase in the software life cycle model.
Exploring migration dynamics and housing markets in transition countries: Recommendations for city management and public health
Authors: Assylbayev Aidar Baymoldaevich , Niiazalieva Kunduzkul Nasirdinovna , Ploskikh Viktoriia Vasilevna , Kumskov Gennadii Vladimirovich , Ploskikh Elena Victorovna
Published: July 2024

This article investigates the multifaceted challenges resulting from concentrated and unidirectional migration to Bishkek, the capital of the Kyrgyz Republic. The study addresses the urgent need to rectify disparities in internal migration patterns and housing opportunities within Bishkek. By analyzing the intricate relationship between housing dynamics and migration inflows, the research underscores the critical importance of these dynamics for effective urban planning. A novel approach is proposed, advocating for the creation of a Bishkek agglomeration model aimed at fostering more balanced urban development and creating an accessible environment for public health. The primary objective of this study is to elucidate the correlation between the construction of new housing infrastructure and the overall state of housing deprivation across the country. The findings provide valuable insights and recommendations for administrative bodies responsible for managing migration and housing policies aimed at creating a healthy living environment.
Automated text analysis methods to identify the individual structure of motivation for sports and a healthy lifestyle
Authors: Kashkin Vasily , Haladay Diana J.
Published: July 2024

In this study, we set two goals: develop and test a method for assessing a person’s motivational profile, based on psychological and content analysis of the text and applicable to motivation for sports and a healthy lifestyle and test automated text analysis programs based on artificial intelligence and compare their performance with each other and with traditional expert content analysis. The selection of programs was made from 65 text analysis programs and 12 artificial intelligence-based chatbots. A total of 12 texts were used for the study, including three long interviews and speeches, and 9 short (2-6 sentences) posts on social media and online media. The evaluated texts contain 5,787 words, of which 91% are originally in Chinese and 9% in English. The content analysis methodology was substantiated in detail in our previous publications.
Innovative approaches to the labor rehabilitation of minors through sports and wellness programs
Authors: Rasulzhan kyzy Zhanyl , Alieva Malika Alybekovna , Abdukakharova Takhmina , Tokoshov Rakhim , Makambai Maksat
Published: July 2024

The article discusses innovative approaches to the labor rehabilitation of minors through the use of sports and wellness programs. The role of physical exercises and sports activities in the process of recovery and rehabilitation of adolescents involved in work is analyzed. Special attention is paid to the legal aspects and regulations governing the labor relations of minors in this area. The paper provides examples of successful programs and projects aimed at rehabilitating adolescents through physical activity, and discusses the prospects for the development of these methods in the context of modern socio-economic conditions.
Perception of Kyrgyz music as a factor of motivation to a healthy lifestyle: Survey
Authors: Baigaziev Daniiar Talantbekovich , Keldibekova Alina Sultanbekovna , Khabibullaeva Nazgul Zulumbekovna , Naimanova Cholpon Kaparovna , Dzhumalieva Gulnura Kabylbekovna
Published: July 2024

The aim of this research is to identify the relationship between perception of Kyrgyz music and motivation for healthy lifestyle, and to understand the mechanisms of music impact on people's behavior within the context of healthy lifestyle. The research methods included literature review, questionnaire development and statistical analysis of data. A total of 248 participants, dominantly young people and women, took part in the online survey. Results showed that musical lyrics covering themes of health, physical activity, and positive thinking can inspire listeners to lead healthy lifestyles. Key images of space, emotions and natural phenomena in Kyrgyz song lyrics reflect the diverse understanding of health and well-being in the culture of Kyrgyz people. Both great composers of the past and modern musicians motivate Kyrgyz people to take care of their health with their patriotic and lyrical songs. The novelty of the research is in the study of a relatively new area of the influence of music on people's behavior within the scope of a healthy lifestyle.
Biologically valuable components of grape stems
Authors: Grishin Yuriy , Oleinikov Nikolay , Ryndach Marina , Kazak Anatoliy , Musakin Alexey , Churilina Irina , Chernenok Mariya , Kryukova Anastasia
Published: July 2024

The current problem of recycling winemaking waste is largely determined by the lack of technological cycles and waste-free technology schemes that can ensure the rational use of natural resources, including grape stems, when creating functionally new composite compositions designed to support human immunity and health. The most effective way to recover raw materials from grape stems is to produce extracts from them. As part of the study, the qualitative and quantitative phenolic composition of grape stem extracts was established. The methodology and technological regimes for the preparation of grape stems, as well as the ranges for varying the content of biologically valuable components in extracts from the stems, have been established. The use of the proposed scheme for obtaining extracts will allow us to separate the process of extracting the components of grape stems from infusion and will allow us to develop a number of technological advantages: targeted regulation of the quality of grape processing products, more complete use of raw materials, and reduction of losses of basic and auxiliary materials.
Psychological and educational aspects of students’ adaptation in the context of digitalization
Authors: Melkumyan Anahit , Sahakyan Maria
Published: July 2024

This article aims to identify the factors that influence the academic performance of undergraduate students, focusing on digital literacy, digital knowledge and skills, as well as personal characteristics in the digital economy. To identify these relationships, surveys were conducted among students using appropriate online questionnaires, and the Big Five Personality Traits (BFPT) testing methodology was chosen to assess the personal qualities of undergraduate students. The findings of the study are consistent with the research in the field indicating a correlation between digital skills and student academic success and simultaneously the inverse impact of social media on academic performance. In addition, the study showed that there is also a positive relationship between some personal traits as conscientiousness, agreeableness and academic performance outcomes. Research illustrates the significant role of gender in academic achievement, explaining how differences in male and female personality traits can influence academic performance and adaptability. The results confirm that academic success and, thus, the ability to adapt to the changing conditions can be explained by personal traits and digital technologies used while the other possible factors can include gender, professional and cultural background.
RETRACTED: Dynamics of a beam with variable cross-section protected from vibration
Authors: Dusmatov Olimjon , Khodjabekov Muradjon , Kasimova Feruza
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: The influence of cyclic temperature and humidity effects on the compressive strength of heavy concrete
Authors: Garanzha Igor , Tanasoglo Anton , Pisareva Milena , Gorokhov Yevgeniy , Smirnova Natalia
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Improvement of tribological parameters of carbon-carbon material by modification of the friction surface
Authors: Roshchin M.N.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Increasing technological sovereignty in dump trucks production facing economic sanctions
Authors: Dubinkin D.M. , Golofastova N.N.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Experimental determination of the parameters of the adaptive support of the power unit of the machine-tractor unit
Authors: Khaliullin Farit , Zimina Larisa , Egorov Sergey , Khaliullin Airat , Pikmullin Gennady , Molochnikov Denis
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Investigation of tribological parameters of friction pairs during lubrication with hydraulic fluid and mineral oil
Authors: Roshchin M.N.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Analysis of the adhesion strength of the A550 reinforcement to concrete B25, B30 and B40
Authors: Pegin P.A. , Pavlovets A.V.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Transport system and transport education development: Some challenges and opportunities
Authors: Nadtochiy Yulia , Mikaeva Anzhela
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Assessment of the frame strength of a passenger trolley model KVZ-TsNII in the Femap software package
Authors: Martynenko L.V. , Tsvik L.B.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Development of the electric vehicle market in Russia and China
Authors: Gorodnova Natalia
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Preventive geochemical barriers during transport construction
Authors: Shershneva M.V. , Lagzdina A.S.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Increasing the role of transport enterprises in strengthening the financial stability of the region
Authors: Khasanov Bakhodir , Hasanova Risolat , Akramov Golibjon , Nurmanov Karjaubay , Akramov Abdulla
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Reduction of additional pressure from ground construction on the subway escalator tunnel
Authors: Sokornov A.A. , Konkov A.N. , Konstantinov V.D.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Use of industrial waste in the production of non-autoclaved foam concrete
Authors: Vishtorsky Evgeny , Bogomolov Sergey , Smirnov Aleksandr , Mutalibova Gavakhirat
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Soil salinity effects on hydrolase and oxidoreductase class enzymes
Authors: Umarov Otabek , Bafayeva Zahro , Atayeva Zamira
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: The significance of alhagi in climate moderation and prevention of pastures degradation
Authors: Jumayev Farhod
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Problems of fertilizer application in developed agriculture and their solution
Authors: Siddiqov Saidjon , Razoqova Durdona
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Verification of efficiency of shear test methodology of geosynthetic composite
Authors: Somov D.N. , Igoshev I.S.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Improving the standardization of wagon standby time at the sorting station
Authors: Butunov Dilmurod , Mukhammadiev Komil , Abdukodirov Sardor , Buriyev Shuhrat , Toxtakxodjaev Mafirat
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Analysis of research on smart rail circuits
Authors: Aliev Ravshan , Turdiev Odilzhan
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Determination of cutting modes when turning railway wheelsets used in heavy traffic
Authors: Kononov D.P. , Karaulshchikova E.A.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Methodological approach to solving the problem of increasing energy efficiency in residential buildings
Authors: Ovchinnikova Svetlana , Konstantinov Ivan , Radwan Hussein , Martynyuk Alexey , Nikolenko Vladislav
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Analysis of input angles of fibrous masses of exhaust steam devices
Authors: Dadakhanov Nurilla , Karimov Rustam
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Experimental determination of the thermal conductivity of building materials under operating conditions
Authors: Frolova Anastasiya , Ledovskikh Ilya , Panin Kirill , Ramazanov Eldar
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Nature-like power industry
Authors: Tkachenko Yuriy , Morozov Sergey , Sherbakova Irina
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Studying temperature and moisture conditions of building envelopes using a condensation nomogram
Authors: Zubarev K.P. , Rynkovskaya M. , Fedoseev V.D. , Sapronova Y.A.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Modeling of the process of retaining the concentration of aggressive gases during the operation of deaerators
Authors: Khuzhakulov Saydullo , Murodov Ismoildjon , Uzbekov Mirsoli , Meyliev Laziz , Pardaev Zokir
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Using blast energy as an effective technology to provide subgrade stability in road construction
Authors: Gorodnova E.V. , Tcvetkov A.A.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Energy security and sustainable development from the standpoint of energy paradigm of Iran
Authors: Guzikova Liudmila , Niyetalina Gaukhar , Ahmadi Simin Shahbazi , Israilova Elima , Shmatko Larisa
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Energizing Karachi: Uncovering solutions for long-standing shortfalls
Authors: Subhani Muhammad Imtiaz , Razakova Dina , Dudukalov Egor , Kozlova Elena , Shahbaz Muhammad
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: International north-south transport corridor: New economic and trade opportunities for India and Armenia
Authors: Grigoryan Karen , Khachikyan Sos , Avetisyan Artur , Egnatosyan Siranush
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Eco-green transport and logistics terminal with the suspended cable car
Authors: Kotesov Anatoly , Kotesova Anastasia
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Optimization of streaming processes in ecosystems of transport and logistics services using digital technologies
Authors: Gubar M. , Kotova E. , Sivertseva E.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Perspectives for the development of safe-ecosystems based on 5-pl logistics in Russia
Authors: Chechenova L.M. , Toschev V.V.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Methodological features of the development of intelligent information technology for the transportation process in railway transport
Authors: Smirnov F.A. , Novichikhin A.V. , Kovalev K.E.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: The problem of pedestrian evacuation of people from high-rise buildings
Authors: Parfyonenko Alexander
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Increase of oil product pipeline throughput capacity by means of an anti-turbulent additive
Authors: Fugarov D.D. , Purchina O.A. , Purchina A.D.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Types of offshore drilling platforms
Authors: Norina Natalia
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Improvement of the design of a vertical steel tank for oil and petroleum products
Authors: Saveleva N.N.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Prospects for the implementation of SWAG-technology to enhance oil recovery at the Rechitskoe field using flue and flare gases
Authors: Drozdov Alexander , Gorelkina Evgeniya
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Transmission diagnostics of single-rotor helicopters
Authors: Reshenkin Andrey , Kochkovaya Natalia , Ezdanyan Valerik
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Assessing the prospects of distributed ledger technology (DLT) development as an element of digital ecosystem of railway transport
Authors: Lyakina M.A. , Fedorov A.E.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Positive and negative aspects of using personal mobility devices on the road network
Authors: Yung Anastasia , Shevtsova Anastasia , Buchkova Christina
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Comparison of ChatGPT and Bard for using in hybrid intelligent information systems
Authors: Kim Radmir , Kotsenko Anton , Andreev Aleksandr , Aladin Dmitry , Varlamov Oleg
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Optimal utilization of multicore processors with PLINQ in .NET applications
Authors: Zaripova Rimma , Aygumov Timur , Kovrizhnykh Olga , Akhmetshin Dinar , Nuriev Marat
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: User identification and authentication in browser environments via machine learning
Authors: Uymin Anton
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: RAID: Data reliability and performance analysis
Authors: Khasan Rakheb Abu , Khomonenko Anatoly
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Using web enables model for real-time ecological data warehouse
Authors: Silachan Klaokanlaya , Intrarasombat Ouychai
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Simulation modeling of infrastructure objects as a management tool of intelligent transport system
Authors: Volkova E. , Romanov A.
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Improvement of tools to assess the implementation of financial potential of corporations
Authors: Zakirova Alsou , Klychova Guzaliya , Ostaev Gamlet , Kondratiev Dmitry , Nigmetzyanov Almaz , Nikitenko Igor
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Benchmarking is a tool for the development of an industrial company
Authors: Pasholikov Maxim
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: State regulation of the use of ESG methodology
Authors: Misnikova Lyudmila , Aleksandrov Igor , Parshukov Aleksey , Maksina Svetlana , Ilina Victoria , Terentyev Alexey , Ol Ekaterina
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Assessment and management of financial risks in multinational companies
Authors: Shokhnekh Anna , Pizengolts Vladimir , Kanoosh Ahmed Dakhil , Alesina Natalya
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Instrumental and methodological approaches to the assessment of franchising in regional entrepreneurship
Authors: Telyatnikova Victoria , Syrbu Anzhelika , Zudin Evgeny , Zakharchenko Flor
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Construction of a multifunctional recreational complex
Authors: Shcherbakova Irina , Kovalchuk Nadezhda , Soprantsova Julia
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Risk factors of technological development of industrial regions of the Russian Federation
Authors: Uzhegov Artyom
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Factors of sustainable development of labour productivity in capital repairs in the Russian Federation and the EU
Authors: Fatullaev Rustam , Borovkova Anastasia , Lotkin Viktor , Sedov Dmitry
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
RETRACTED: Navigating sustainability: The role of environmental accounting in enhancing business performance
Authors: Shatila Khodor , Nurzhaubayeva Raissa , Malishevskaya Natalia , Podolskaya Tatiana
Published: July 2024

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001
Prise en charge de la néphropathie lupique en 2023
Authors: Houssiau Frédéric A.
Published: July 2024

La néphropathie lupique reste la complication sévère la plus fréquente du lupus érythémateux disséminé. Elle évolue vers l’insuffisance rénale chronique dans 20 à 25 % des cas. Son traitement moderne repose sur l’utilisation combinée d’un traitement immunosuppresseur et de biothérapies ciblées pour optimiser les chances d’obtenir rapidement et de maintenir au long cours une réponse rénale complète. L’auteur discute ces progrès récents.
Convergence of Lattice Boltzmann methods with overrelaxation for a nonlinear conservation law
Authors: Aregba-Driollet Denise
Published: July 2024

We approximate a nonlinear multidimensional conservation law by Lattice Boltzmann Methods (LBM), based on underlying BGK type systems with finite number of velocities discretized by a transport-collision scheme. The collision part involves a relaxation parameterwwhich value greatly influences the stability and accuracy of the method, as noted by many authors. In this article we clarify the relationship betweenwand the parameters of the kinetic model and we highlight some new monotonicity properties which allow us to extend the previously obtained stability and convergence results. Numerical experiments are performed.
Experiences of (Potentially) Traumatizing Deployments and
Posttraumatic Stress in Police Officers: An Exploratory Survey of Early Career
Police Officers
Authors: Posch Lena , Zube Anna-Lena
Published: July 2024

Background As part of their career, police officers are faced with
traumatic events on a regular basis and are at a higher risk of developing
post-traumatic-stress disorder (PTSD) compared to the general population. The
aim of this study was to examine if and how many early career police officers
had already experienced potentially traumatizing situations and how many met
either subsyndromal or complete PTSD criteria. A further subject of interest was
if the officers knew the concept of psychosocial emergency care for first
responders (PSNV-E) and if such support was made use of.

Method Early career police officers (n=221) were assessed via an
online survey about their posttraumatic stress symptoms.

Results More than half of the participants (n=121) reported having
experienced at least one traumatic deployment. PTSD prevalence in this group was
at 1.7%, an additional 14.9% showed partial PTSD. One-fifth did not know about
the PSNV-E concept.

Conclusion Police officers are confronted with a range of extremely
stressful events early in their career leading to first symptoms of PTSD in some
of them. Early prevention strategies as well as the identification of those
affected for secondary prevention is of very high relevance for long-term mental
health.
Langzeitergebnisse nach Rekonstruktion von Fingerdefekten mittels
Cross-Finger-Lappenplastik
Authors: Mulica Markus , Yasmin Mohamed , Cai Aijia , Arkudas Andreas , Müller-Seubert Wibke , Horch Raymund E
Published: July 2024

Ziel Cross-Finger-Lappenplastiken sind trotz aller Fortschritte in der
mikrochirurgischen Rekonstruktion von Fingerdefekten weiterhin ein probates
Rekonstruktionsverfahren. Daten zu Langzeitergebnissen sind jedoch in der
Literatur spärlich. Diese retrospektive, unizentrische Kohortenstudie untersucht
die klinischen und subjektiven Ergebnisse nach Haut- und Weichteilrekonstruktion
an den beugeseitigen Fingern sowie nach Fingerkuppen-Amputation mittels
Cross-Finger-Lappenplastik.

Patienten und Methoden Die Studie umfasste Patienten/-innen, bei welchen
zwischen Januar 2003 bis Juli 2022 eine Cross-Finger-Lappenplastik zur
Rekonstruktion von isolierten Haut- und Weichteilverletzungen an den Fingern
durchgeführt wurde. Insgesamt konnten 35 Patienten/-innen (31 Männer, 4 Frauen,
Durchschnittsalter: 59,0 Jahre±20,1) mittels klinischer Untersuchung und mittels
Quick-DASH-Score sowie einem eigens entwickelten Fragebogen nachuntersucht
werden. Die klinische Nachuntersuchung umfasst die Bestimmung des
Bewegungsradius des rekonstruierten Fingers und des Spenderfingers sowie der
Sensibilität im Bereich der Cross-Finger-Lappenplastik. Der
Nachuntersuchungszeitraum belief sich zwischen 1 und 19 Jahren (Mittelwert: 12,6
Jahre±6,1).

Ergebnis Es ergab sich kein signifikanter Unterschied hinsichtlich der
Beweglichkeit des rekonstruierten Fingers und des Spenderfingers im Vergleich
zur kontralateralen gesunden Hand. Alle Patienten berichteten über eine
regelrechte Spitz-/Stumpf-Diskrimination. Es bestand jedoch ein signifikanter
Unterschied hinsichtlich der 2-Punkte-Diskrimination im Bereich der
Cross-Finger-Lappenplastik im Vergleich zu dem gesunden kontralateralen Finger
(p<0,05). Der Quick-DASH-Score belief sich durchschnittlich auf 5,1 von 10
Punkten. Die Zufriedenheit mit dem funktionellen Ergebnis hinsichtlich der
Beweglichkeit und Belastbarkeit der Cross-Finger-Lappenplastik lag
durchschnittlich bei 8,1 von 10 Punkten. Die Zufriedenheit mit dem ästhetischen
Ergebnis des rekonstruierten Fingers lag durchschnittlich bei 7,7 von 10
Punkten. In 4 Fällen wurde von persistierenden Schmerzen bei Belastung des
rekonstruierten Fingers berichtet. In keinem Fall wurde ein Ruheschmerz
beobachtet.

Schlussfolgerung Die Cross-Finger-Lappenplastik stellt ein sicheres und
sinnvoll einsetzbares rekonstruktives Verfahren zur Defektdeckung von palmaren
Verletzungen sowie Fingerkuppen-Amputationen der Finger dar. Im Langzeitverlauf
sind keine Bewegungseinschränkungen aufgrund der temporären iatrogenen
Syndaktylie zu beobachten.
Serum Leucine Aminopeptidase Activity Patterns Across Various Disease States: Potential Implications for Bleeding and Thrombosis Risk
Authors: Yu Sha , Zhang Meng , Guo Yachong , Zhang Lijuan
Published: July 2024

Background Disruptions in the pathways for activating and deactivating proteases in the bloodstream can lead to thrombosis and bleeding issues. Leucine aminopeptidases (LAPs), which are exopeptidases essential for regulating protein and peptide activities, are recognized as clinical biomarkers for liver diseases. However, the relationship between serum LAP activity and the risks of bleeding or thrombosis, as well as the identification of the specific tissues or organs that control LAP levels, is not well understood.

Methods We performed a retrospective study to evaluate serum LAP activities in 149,360 patients with 47 different diseases and 9,449 healthy individuals. The analysis was conducted using SPSS V2.6, RStudio V.1.3.1073, and libraries in Python 3.8.

Results Our research revealed that 21 of the 47 diseases studied showed increased median serum LAP activities, while 26 diseases were associated with significantly lower activities, especially those related to thrombosis. Furthermore, most diseases were found to have an increased risk of bleeding and thrombosis, indicated by higher Q25 and lower Q75 LAP activities compared to the control group. Receiver operating characteristic curve analysis confirmed the effectiveness of LAP activities as biomarkers for specific conditions like hepatic encephalopathy, liver cancer, pancreatitis, and pancreatic cancer. Diseases were categorized into clusters with similar bleeding or thrombotic tendencies through principal component analysis.

Conclusion This study highlighted regulatory influence of the liver and pancreas on LAP levels. The established link between serum LAP concentrations and the risk of bleeding or thrombosis paved the way for the development of diagnostic and preventative approaches for various medical conditions.
From Data to Manuscript: A Strategy for Young Oncologists to Write a Scientific Paper
Authors: del Giglio Auro , de Cubero Daniel Iracema Gomes , da Costa Mateus Uerlei Pereira
Published: July 2024

Scientific manuscripts are the basis for the transmission of scientific data among physicians in all fields of medicine. To teach young oncologists the skills needed to author a paper, we decided to emulate how experienced clinicians perform this task. The first step is to create a spreadsheet with all the clinical data gathered and submit it to a statistical analysis using a statistical software package. The most important results are presented in the graphs and tables. The results should be explained in a logical and understandable manner. Writing the “Materials and Methods” section follows, with all the technical information that any other researcher may need to reproduce elsewhere the study in question. A critical-thinking stage, in which a review of the pertinent literature is conducted with the use of a reference management software, should provide all the knowledge and questions to write the “Introduction” and “Discussion” sections. The “Abstract” and “Title” are the final sections to be created. Following these steps, the author can correct the first draft of the manuscript for submission to a specific journal. Choosing the right journal and answering the reviewers' comments are also important steps in this process. Even if a young oncologist does not embark on an academic career, learning how to write a scientific manuscript is believed to be the best way to teach them how to read such manuscripts during their lifelong continuous self-education.
Recent Advances in Mitochondrial Pyruvate Carrier Inhibitors
Authors: Huang Yilei , Zhang Han , Peng Xinyan , Zhang Qingwei
Published: July 2024

The mitochondrial pyruvate carrier (MPC) exists in the mitochondria inner membrane which transports pyruvate to the mitochondrial matrix. Evidence shows that MPC is the breakthrough point to study the regulation of basic energy metabolism, the dysfunction of which may lead to metabolic disturbance. Due to its important metabolic function, MPC has been considered a potential therapeutic target for diabetes, alopecia, cancers, neurodegenerative diseases, and liver metabolic diseases. However, MPC' protein crystal structure is still not clear as the proteins involved were only identified 10 years ago, making it difficult to carry out rational drug design based on receptor structure. In this review, we summarize the latest applications of MPC in different diseases and discuss the recent advances in pharmacochemical strategies of small-molecule inhibitors of MPC, hoping to promote the development of specific MPC inhibitors.
Discovery of a Novel Benzimidazole Necroptosis Inhibitor from an In-House Compound Library
Authors: Zou Yu , Chai Yue , Shao Hongming , Wang Shuyu , Hou Ruilin , Liu Runhui , Zhao Linjing , Zhuang Chunlin
Published: July 2024

Necroptosis, a caspase-independent regulated cell death, is primarily mediated by the serine/threonine kinases RIPK1 and RIPK3, and the mixed lineage kinase domain-like protein (MLKL). Targeting necroptosis is a validated therapeutic strategy for various diseases. We screened compound 1, a novel benzimidazole-based necroptosis inhibitor, from our in-house compound library. We assessed its inhibitory roles and mechanisms in blocking HT-29 cell necroptosis. HT-29 cells were treated with pan caspase inhibitor Z-VAD-FMK + Smac mimetic (TSZ), or Z-VAD-FMK + cycloheximide (TCZ), then with tumor necrosis factor α (TNFα) to induce necroptosis in vitro. Prior to stimulation, cells were exposed to compound 1. GSK'843 served as a control drug. HT-29 cells were treated with TNFα + Smac mimetic (TS) or TNFα + cycloheximide (TC) to induce apoptosis in vitro. Cell viability, cell death, and necroptotic cells were evaluated by luminescence-based CellTiter-Lumi assay or flow cytometry. Western blots, immunoprecipitation, and KINOMEscan technology were used to assess RIPK1, RIPK3, and MLKL's involvement in compound 1's mechanisms. Compound 1's roles in mouse TNFα induced systemic inflammatory response syndrome (SIRS) in mice were also investigated by assessing body temperature, mouse survival rate, and interleukin (IL)-β and IL-6 levels in respective tissues. We found that necroptosis triggered by TSZ or TCZ was effectively mitigated by compound 1, showing a dose-responsive inhibition, and it could protect mice from TNF-induced SIRS. The mechanism study showed that compound 1 could interact with RIPK1, inhibiting RIPK1 phosphorylation activation to block necrosome formation in necroptotic cells. In summary, compound 1 is a promising lead compound for developing treatments targeting diseases associated with necroptosis.
X-Linked Myotubular Myopathy and Mitochondrial Function in Muscle and Liver Samples
Authors: Inoue Kenji , Kato Takeo , Terasaki Eisuke , Ishihara Mariko , Fujii Tatsuya , Aida Yuko , Murayama Kei
Published: July 2024

X-linked myotubular myopathy (XLMTM) is a rare congenital myopathy that commonly manifests with liver involvement. In most XLMTM cases, disease-causing variants have been identified in the myotubularin gene (MTM1) on chromosome Xq28, which encodes myotubularin protein (MTM1). The impairment of mitochondrial respiratory chain (MRC) enzyme activity in muscle has been observed in the XLMTM mouse model. Though several reports mentioned possible mechanisms of liver involvement in XLMTM patients and animal models, the precise underlying mechanisms remain unknown, and there is no report focused on mitochondrial functions in hepatocytes in XLMTM. We encountered two patients with XLMTM who had liver involvement. We measured MRC enzyme activities in two muscle biopsy specimens, and one liver specimen from our patients to investigate whether MTM1 variants cause MRC dysfunction and whether mitochondrial disturbance is associated with organ dysfunction. MRC enzyme activities decreased in skeletal muscles but were normal in the liver. In our patients, the impaired MRC enzyme activity found in muscle is consistent with previously reported mechanisms that the loss of MTM1-desmin intermediate filament and MTM1-IMMT (a mitochondrial membrane protein) interaction led to the mitochondrial dysfunction. However, our study showed that liver involvement in XLMTM may not be associated with mitochondrial dysfunction.
Copy Number Alteration of Cyclin D1 (CCND 1) Gene as a Prognostic Factor in Oral Squamous Cancers and its Correlation with Immunohistochemistry (IHC)
Authors: Ratnagiri Ranganath , Jena Shubhranshu , Ranganath Prajnya , Uppin Megha S. , Shantappa Rajashekar
Published: July 2024

Background Oral squamous cancers remain the most common cancers among males in India and the third most common cancer among men and women combined, with an age standardized ratio of 9.1 per 100,000 population. Surgery and chemoradiation have not improved survival rates significantly and hence, newer therapeutic targets are needed. Cyclin D1 (CCND1) is a proto-oncogene which is located on chromosome 11q13 and has been found to be amplified in many cancers including oral cancers. It is said to correlate with aggressive tumor growth and a poorer prognosis.

Aim This article correlates cyclin D1 (CCND1) gene copy number alteration with clinicopathologic prognostic factors in oral squamous cancers.

Materials and Methods Sixty-three patients who underwent surgery for oral cancer between January and June 2022 were included in the study after obtaining informed consent and ethics approval. Copy number alteration of CCND1 was assessed using quantitative polymerase chain reaction (Qf PCR) and correlated with clinical and histopathological prognostic factors, including short-term recurrence. Statistical analysis was performed using the SPSS software.

Results A statistically significant correlation was determined between the Qf PCR values of CCND1 gene and locoregional recurrence. Gene copy number alteration also correlated strongly with a higher grade of the primary tumor. There was also a significant correlation between the Qf PCR values and the immunohistochemistry for cyclin D1.

Conclusion Cyclin D1 offers a new therapeutic target in oral cancers and may improve survival without significant treatment-related morbidity.
Effect of tensile and compressive strain on the gate leakage current and inverse piezoelectric effect in AlGaN/GaN HEMT devices
Authors: Zhang Yiqun , Zhu Hui , Liu Xing , Zhang Zhirang , Xu Chao , Ren Keyu , Guo Chunsheng , Zhang Yamin , Zhou Lixing , Feng Shiwei
Published: July 2024

The influence of external strain on the gate leakage current of AlGaN/GaN high-electron-mobility transistors was studied. The magnitude of the leakage current increased by 39% under 0.1% tensile strain but decreased by 23% under −0.1% compressive strain. The leakage current obeyed the Poole–Frenkel conduction mechanism, demonstrating a decrease/increase in the barrier height for electron emission from the trap state into the continuum dislocation state. Furthermore, the magnitude of critical reverse stressing voltage for the onset of degradation induced by the inverse piezoelectric effect became lower/higher under tensile/compressive strain compared with that of the initial state, which was attributed to the modification of the total stress in the film. In addition, using the transient current method, it was established that the detrapping time constant for the traps in the AlGaN barrier increased as a result of the tensile strain, which is ascribed to movement of the dislocation level away from the conduction band.
Spin orientation evolution of individual ferromagnetic nanoparticle during reversing magnetization processes revealed by micromagnetic simulations
Authors: Ku Jiangang , Li Xin , Wang Zhaolian , Wang Qian , Xue Fei
Published: July 2024

Understanding the internal magnetization structure of an individual ferromagnetic nanoparticle (MNP) is crucial for deciphering its magnetic characteristics. Unfortunately, while certain techniques can measure the magnetic properties of an individual MNP, they fall short of accurately detecting the internal magnetization structure. In this work, micromagnetic simulations were employed to construct the internal magnetization structure of an individual CoFe2O4 (CFO) nanopyramid, and the energy jump behavior during the magnetization process was successfully explained, with simulation results aligning with dynamic cantilever magnetometry (DCM) experimental outcomes. Subsequently, the external stray field of the nanopyramid was simulated, and the stray field gradient map revealed distinct bright and dark regions corresponding to the reverse and forward saturation magnetizations of the CFO nanopyramid. This result is possible to be verified by magnetic force microscopy (MFM) measurements of individual CFO nanopyramids. The confidence in the accuracy of the simulated internal magnetization structure was significantly enhanced by independently verifying the micromagnetic simulation results through DCM and MFM experiments. Our work proposes a convenient and cost-effective method for studying the internal magnetization structure of individual MNPs.
Fundamental difference between the mechanisms of electrostatic field screening in dense and thoroughly collisionless plasmas
Authors: Rosenfeld E. V.
Published: July 2024

When an external electric field appears in a homogeneous plasma, ions move into regions where their electrostatic energy is lower. Simultaneously, forces arise that counteract this effect, causing the plasma to reach equilibrium when the field disappears completely. In collisional plasma, the resulting charge inhomogeneities decrease both Coulomb energy and entropy. Randomly induced diffusion flows tend to hinder their growth, minimizing free energy at any point. Accordingly, in the Debye–Hückel theory, the external field strength decreases exponentially with distance within the plasma. In a collisionless plasma, an antiscreening mechanism operates differently. Each ion moves in a self-consistent field along distinct trajectories, following classical dynamics laws. An external field bends these trajectories, bringing ions into regions where their Coulomb energy is lower. The antiscreening mechanism occurs when ions accelerate into potential wells, increasing the distances between them along their trajectories and decreasing their number densities along these paths. The law of energy conservation for any single ion governs this principally nonlocal process, and the dependence of field strength on distance is not necessarily exponential. This paper demonstrates that the Debye–Hückel theory should not be used to describe the charge density distribution within an unrestricted stream of collisionless plasma, such as the solar wind. It also analyzes non-exponential solutions of the Poisson equation for plasma sheaths above flat surfaces, from which such a flow takes off and on which it falls, obtained in quadratures.
Pressure-induced optical anisotropy of HfS2
Authors: Antoniazzi Igor , Woźniak Tomasz , Pawbake Amit , Zawadzka Natalia , Grzeszczyk Magdalena , Muhammad Zahir , Zhao Weisheng , Ibáñez Jordi , Faugeras Clement , Molas Maciej R. , Babiński Adam
Published: July 2024

The effect of pressure on Raman scattering (RS) in bulk HfS2 is investigated under hydrostatic and non-hydrostatic pressure conditions. The RS line shape does not change significantly in the hydrostatic regime up to P = 9.6 GPa, showing a systematic blueshift of the spectral features. In a non-hydrostatic environment, seven peaks appear in the spectrum at P = 7 GPa, which dominate the RS line shape up to P = 10.5 GPa. The change in the RS line shape manifests a pressure-induced phase transition in HfS2. The simultaneous observation of both low-pressure (LP) and high-pressure (HP) related RS peaks suggests the coexistence of two different phases over a wide pressure range. It is found that the HP-related phase is metastable and persists during the decompression cycle down to P = 1.2 GPa, while the LP-related features eventually recover at even lower pressure. The angle-resolved polarized RS performed under P = 7.4 GPa revealed a strong in-plane anisotropy of both the LP-related A1g mode and the HP peaks. The anisotropy is related to the possible distortion of the structure induced by the non-hydrostatic component of the pressure. The results are explained in terms of a distorted Pnma phase as a possible pressure-induced phase of HfS2.
A reduced cost four-component relativistic unitary coupled cluster method for atoms and molecules
Authors: Majee Kamal , Chakraborty Sudipta , Mukhopadhyay Tamoghna , Nayak Malaya K. , Dutta Achintya Kumar
Published: July 2024

We present a four-component relativistic unitary coupled cluster method for atoms and molecules. We have used commutator-based non-perturbative approximation using the “Bernoulli expansion” to derive an approximation to the relativistic unitary coupled cluster method. The performance of the full quadratic unitary coupled-cluster singles and doubles method (qUCCSD), as well as a perturbative approximation variant (UCC3), has been reported for both energies and properties. It can be seen that both methods give results comparable to those of the standard relativistic coupled cluster method. The qUCCSD method shows better agreement with experimental results due to the better inclusion of relaxation effects. The relativistic UCC3 and qUCCSD methods can simulate the spin-forbidden transition with easy access to transition properties. A natural spinor-based scheme to reduce the computational cost of relativistic UCC3 and qUCCSD methods has been discussed.