bluuebunny/crossref_metadata_2025 huggingface dataset:
Al(iii)-based MOF for the selective adsorption of phosphate and arsenate from aqueous solutions
Authors: Obeso Juan L. , Viltres Herlys , Flores Catalina V. , López-Cervantes Valeria B. , Serrano-Fuentes Camilo , Rajabzadeh Amin Reza , Srinivasan Seshasai , Peralta Ricardo A. , Ibarra Ilich A. , Leyva Carolina
Published: September 2023

Schematic representation of the application of DUT-5 to remove phosphate and arsenate from aqueous solutions.
Synthesis and biological evaluation of 1,2,4-triazoloazines as potent anticancer agents
Authors: Serebrennikova Polina O. , Paznikova Julia A. , Kirnos Eva A. , Utepova Irina A. , Kazakova Elizaveta D. , Lazarev Vladimir F. , Kuznetcova Liubov S. , Margulis Boris A. , Guzhova Irina V. , Chupakhin Oleg N. , Sarapultsev Alexey P.
Published: September 2023

The new derivatives of mono- and bis-1,2,4-triazoloazines were obtained. The cytotoxic activity of the compounds was evaluated against the cancer cell lines.
Bi-directional strains increase the performance of iridium oxide nanoparticles towards the acidic oxygen evolution reaction in proton exchange membrane electrolyzers
Authors: Wu Xiao , Hao Shaoyun , He Yi , Lei Lecheng , Zhang Xingwang
Published: September 2023

The challenge of achieving high-performance iridium-based catalysts towards the oxygen evolution reaction in proton exchange membrane electrolyzers remains unresolved due to the highly acidic catalyst/PEM interface and oxidation conditions.
Magnetic hybrid transition metal halides
Authors: Chen Zhongwei , Xue Jie , Wang Zhiyu , Lu Haipeng
Published: September 2023

Magnetic transition metal halides possess rich chemical and structural diversity and thus offer a great opportunity for the search of new multifunctional magnetic materials and novel magnetic phenomena.
Advancement of vinylene carbonate as a coupling partner in metal-catalyzed C–H functionalization
Authors: Ge Yicong , Yan Qiang , Nan Jiang
Published: September 2023

Vinylene carbonate (VC) has emerged as a promising coupling partner to participate in various attractive C–H conversions and implement an increasing number of novel reactions. In this review, we provide a summary of the advancements achieved in metal-catalyzed C–H functionalization using VC.
Preparation of reversible cross-linked amphiphilic polymeric micelles with pH-responsive behavior for smart drug delivery
Authors: Tan Liu , Fan Jinling , Zhou Yuqing , Xiong Di , Duan Manzhen , Hu Ding , Wu Zhimin
Published: September 2023

A new type of reversible cross-linked and pH-responsive polymeric micelle (PM) was synthesized for targeted delivery of curcumin.
Dielectric barrier discharge plasma catalysis as an alternative approach for the synthesis of ammonia: a review
Authors: Hosseini Hamideh
Published: September 2023

We discuss the synthesis of ammonia over catalysts using dielectric barrier discharge plasma as a promising alternative approach.
Action at a distance: organic cation induced long range organization of interfacial water enhances hydrogen evolution and oxidation kinetics
Authors: Zhao Kaiyue , Yu Hao , Xiong Haocheng , Lu Qi , Gao Yi Qin , Xu Bingjun
Published: September 2023

The structure-making ability of bulky hydrophobic cations promotes the formation of hydrogen-bonded water chains connecting the electrode surface to the bulk electrolyte, which in turn facilitates the hydrogen oxidation and evolution reactions.
Structural distortion by alkali metal cations modulates the redox and electronic properties of Ce3+ imidophosphorane complexes
Authors: Boggiano Andrew C. , Studvick Chad M. , Steiner Alexander , Bacsa John , Popov Ivan A. , La Pierre Henry S.
Published: September 2023

Structural distortion of the secondary coordination sphere driven by the incorporation of an alkali metal in Ce3+ imidophosphorane complexes tunes the Ce3+/4+ oxidation potential.
Liquid interfaces: an emerging platform for energy conversion and harvesting
Authors: Zhao Sai , Fu Yuchen , Cao Haowu , Chai Yu
Published: September 2023

Liquid interfaces are versatile platforms to enable both chemical and physical reactions, which offers great opportunities to realize energy conversion and harvesting, thus providing more opportunities for obtaining clean energy.
Multicore–shell iron fluoride@carbon microspheres as a long-life cathode for high-energy lithium batteries
Authors: Jiang Ziang , Wang Yujie , Chen Xuanfeng , Chu Fulu , Jiang Xuansi , Kwofie Felix , Pei Qianfan , Luo Shunrui , Arbiol Jordi , Wu Feixiang
Published: September 2023

Multicore–shell iron fluoride@carbon microspheres, synthesized using a bottom-up method, have a quality carbon coat and smaller core size. As a conversion cathode of lithium batteries, it exhibits notable stability over 3500 cycles at 1 C.
A flame retardant benzimidazole-linked covalent organic framework as an organic solution sponge for acceleration of Li+-ion migration in solid-state electrolytes
Authors: Zhang Han , Kong Ya-Ru , Zhang Jin , Ren Xing-Yu , Ren Xiao-Ming
Published: September 2023

Flame retardant PBI-COF acts as an organic liquid electrolyte sponge to absorb LiBF4/PC solution and accelerates Li+-ion conduction through weak coordination interactions.
Electric field and strain engineering tuning of 2D Gr/α-Ga2O3 van der Waals heterostructures
Authors: Wu Xiangyu , Xie Zhiyang , Zhang Yu , Liu Xuefei , Bi Jinshun , Wang Wentao , Zhang Zhaofu , Cao Ruyue
Published: September 2023

The Gr/α-Ga2O3↑ and Gr/α-Ga2O3↓ vdWHs exhibit n-type Schottky contacts with a minimal Schottky barrier height of 0.043 eV and n-type Ohmic contacts, respectively.
Chemical catalysis by biological amyloids
Authors: Wittung-Stafshede Pernilla
Published: September 2023

Toxic aggregation of proteins and peptides into amyloid fibers is the basis of several human diseases. In each disease, a particular peptide noncovalently assembles into long thin structures with an overall cross-β fold. Amyloids are not only related to disease: functional amyloids are found in many biological systems and artificial peptide amyloids are developed into novel nanomaterials. Amyloid fibers can act as template for the generation of more amyloids but are considered nonreactive in chemical catalysis. The perception of amyloids as chemically inert species was recently challenged by in vitro work on three human amyloid systems. With the use of model substrates, amyloid-β, α-synuclein and glucagon amyloids were found to catalyze biologically relevant chemical reactions. The detected catalytic activity was much less than that of ‘real’ enzymes, but like that of designed (synthetic) catalytic amyloids. I here describe the current knowledge around this new activity of natural amyloids and the putative connection to metabolic changes in amyloid diseases. These pioneering studies imply that catalytic activity is an unexplored gain-of-function activity of disease amyloids. In fact, all biological amyloids may harbor intrinsic catalytic activity, tuned by each amyloid's particular fold, that await discovery.
Children With Developmental Language Disorder Show Deficits in the Production of Musical Rhythmic Groupings
Authors: Kreidler Kathryn , Vuolo Janet , Goffman Lisa
Published: September 2023

Purpose:

Children with developmental language disorder (DLD) show evidence of domain-general deficits in sequentially patterned motor skills. This study focuses on the production of rhythmically grouped sequences drawn from a music task, with the hypothesis that children with DLD will show a sequential pattern learning deficit that crosses language and action domains.

Method:

Fifty-seven 4- to 5-year-old children (36 with DLD) drummed and clapped a developmentally appropriate musical rhythmic sequence 24 times (clapped 12 times, drummed 12 times). The accuracy of rhythmic events (markings of claps, drums, and pauses in a target sequence) was assessed through a modification of classic speech and language transcription procedures. The variability and prosodic structure of the rhythmic groupings were also measured.

Results:

Children with DLD produced less accurate and more variable rhythmic groupings compared to their typically developing (TD) peers. While the final-position grouping of the sequence was especially vulnerable for all children, those with DLD included more co-occurring errors in initial and final groupings of the same rhythmic sequence. Both TD children and children with DLD were less accurate in the clapping than the drumming task. Neither rhythmic drumming nor clapping accuracy correlated with motor skill in either group of children.

Conclusions:

This study provides novel evidence of a manual rhythmic grouping deficit in DLD, one that is motivated by language—not motor or speech—factors. Cognitive abilities necessary to organize rhythmic events into higher order groupings are impaired across music and language in children with DLD. Rhythmic organization and sequencing may serve an important role in diagnosis and intervention in this population.

Supplemental Material:

https://doi.org/10.23641/asha.24158745
Pediatric Unilateral Vocal Fold Paralysis
Authors: Barson Paula , Carroll Linda , Zur Karen B.
Published: September 2023

Purpose:

The aim of this case study was to provide a review of a pediatric patient diagnosed with unilateral vocal fold paralysis.

Method:

The case history, voice samples, laryngeal examinations, and diagnostic probes were reviewed in a 10-year-old girl with the chief complaint of persistent dysphonia, characterized by use of both a breathy and a typical voice. Perceptual ratings were completed using both Consensus Auditory-Perceptual Evaluation of Voice and Grade, Roughness, Breathiness, Asthenia, and Strain scales. Cepstral peak prominence was determined and compared for the same file segment using both Praat and Analysis of Dysphonia in Speech and Voice analysis programs. Treatment probes during the initial preoperative visit are described.

Results:

The patient was able to compensate for short phonation tasks, but longer conversations were judged to have increased dysphonia and increased vocal fatigue. Because noted compensation was unable to be stabilized or sustained, both a reinnervation of the ansa cervicalis to the recurrent laryngeal nerve and voice therapy techniques were recommended as part of the multidisciplinary team plan.

Conclusion:

Pediatric patients with unilateral vocal fold paralysis may present with complex phonatory behaviors. This case study paired with supplemental acoustic and videostroboscopy files provides an opportunity to practice both an auditory-perceptual and acoustic assessment and to rate a laryngeal examination.

Supplemental Material:

https://doi.org/10.23641/asha.24163926
Living in the Void Between Hearing Health Care Encounters: Evaluation of the Barriers Families Face
Authors: Richlin Blair C. , Blaiser Kristina M. , Bush Matthew
Published: September 2023

Purpose:

There is a clear need for speech-language pathologists, audiologists, and related health care professionals to understand the barriers to hearing health care, so that we may propose possible solutions. Through interview, collaboration, and analysis, the objective was to identify opportunities to enhance support provided for these children.

Method:

The authors conducted a review of available literature related to hearing health care disparities. Dr. Matthew Bush, an expert in hearing health care disparities and advocacy, was interviewed on October 12, 2022. Data were extracted and compiled from available literature and the interview including demographics, themes, and available interventions.

Results:

The section “Entry Barriers” describes findings in the main categories of Steps, Proximity, Health Care Literacy, and Systemic Inequalities. The “Opportunities for Change” section describes topics from the interview for ongoing discussion in the field.

Conclusions:

Ultimately, having this conversation led exactly in a direction that it should—toward further professional development, awareness, and a call to action. To facilitate meaningful change, we are tasked with active discussion, questioning, probing, and improvement. Only through evolution of existing systemic bias and harmful structures can we make meaningful change.
The Effect of Diffusions and Sources on Semilinear Elliptic Problems
Authors: Abreu Emerson , Medeiros Everaldo , Montenegro Marcos
Published: September 2023

This paper deals with properties of non-negative solutions of the boundary value problem in the presence of diffusion a and source f in a bounded domain Ω ⊂ ℝn, n ≥ 1, where a and f are non-decreasing continuous functions on [0, L0) and f is positive. Part of the results are new even if we restrict ourselves to the Gelfand type case L0 = ∞, a(t) = t and f is a convex function. We study the behavior of related extremal parameters and solutions with respect to L0 and also to a and f in the C0 topology. The work is carried out in a unified framework for 0 < L0 ≤ ∞ under some interactive conditions between a and f
Evaluation of an Emergency Drive System for a Disabled Arterial Pump Head
Authors: Long George W. , Fleenor Jonathan T.
Published: September 2023

This study evaluates an Emergency Drive System (E.D.S.) developed by the authors to provide an electrically
powered drive system for a disabled arterial pump head.

The methods used in this study were designed to evaluate the E.D.S. under simulated clinical conditions using an American Optical Model 16655 pump with 1/2″ tubing in the arterial pump head and a Sarns 5000 pump with 3/8″ tubing in the arterial pump head. The E.D.S. was applied to the .arterial pump head and was required to produce a six liter per minute flow based on the revolutions per minute of the pump head. The study was deemed successful if the E.D.S. was capable of providing the revolutions per minute for a two hour period.

The E.D.S. was capable of providing the 100 revolutions per minute for American Optical pump and the 230 revolutions per minute for the Sarns 5000 pump, necessary to produce a six liter per minute flow rate.

In conclusion our study shows the E.D.S. is an easy and accurate device for providing temporary power to a disabled arterial pump head.
Research on information collaboration strategy of fresh agricultural products supply chain under carbon cap-and-trade
Authors: Yang Yang , Yao Guanxin
Published: September 2023

The information coordination of fresh agricultural products supply chain is conducive to improving the overall efficiency and competitiveness of the supply chain, and reducing carbon emissions. Under the carbon cap-and-trade policy, this paper constructed an evolutionary game model of supply chain information collaboration involving a fresh agricultural products supplier, a cold chain logistics service provider and a fresh agricultural products retailer, explored the selection of information collaboration strategies of each subject, and simulated it with system dynamics. The results show that: The stability strategy of the game system is related to the initial willingness of each subject. When any two parties participate in information collaboration, the other party will also choose to participate in collaboration. In addition, the choice of information collaboration strategy of the subject is also related to the collaborative planning ability, collaborative strategy formulation ability, consumers’ preference, the initial cost of each subject, revenue sharing and cost sharing mechanism, government subsidies, government regulation and carbon cap-and-trade policy. It is worth noting that the collaborative planning capability is more conducive to promoting the subject to choose information collaborative strategy than the collaborative strategy formulation capability; the carbon trading price has a greater impact on the subject’s participation in collaboration, while the total amount of carbon quota has no impact on the choice of the subject’s information collaboration strategy. Furthermore, based on the research results, the corresponding management suggestions are put forward from the two aspects of the government and the participants.
Einsatz von Implantaten zur Versorgung der männlichen Harninkontinenz
Authors: Rojas Cruz Cesar , Hakenberg Oliver , Dräger Desiree Louise
Published: September 2023

Behandlungen für benigne und maligne Erkrankungen der Prostata können die Harnkontinenz beeinträchtigen. Harninkontinenz reduziert die Lebensqualität der Patienten und schränkt ihre Fähigkeit ein, normale Aktivitäten auszuführen. Der Grad der Harninkontinenz ist unterschiedlich und die damit verbundenen Beschwerden veranlassen Patienten dazu, sich behandeln zu lassen. Im Zentrum der Behandlung stehen chirurgische Eingriffe, die durch den Einsatz von Implantaten die beeinträchtigte Schließmuskelfunktion der männlichen Urethra ersetzen sollen. Der künstliche Harnröhrensphinkter gilt seit seiner Entwicklung in den 1970er-Jahren als Standard zur Therapie von männlichen Harninkontinenz. Erst kürzlich hat sich gezeigt, dass artifizielle Sphinkter und Schlingen bei einer ausgewählten Gruppe inkontinenter Männer wirksam sind. Zu den Zielen der chirurgischen Behandlung der Inkontinenz gehören die Erhaltung der Blasenfunktion, die Fähigkeit, die Stärke des Harnröhrensphinkters zu verbessern und den Urinverlust zu reduzieren oder zu beseitigen, und damit die Lebensqualität zu verbessern. Ziel der Artikel ist die Darstellung verschiedener Implantate zur Korrektur der männlichen Harninkontinenz.
Liquid Biopsy – Ein neues diagnostisches Konzept in der Onkologie
Authors: Heidrich Isabel , Roeper Carmen M.T. , Rautmann Charlotte , Pantel Klaus , Smit Daniel J.
Published: September 2023

Die Analyse von im Blut zirkulierenden Tumorzellen oder von in anderen Körperflüssigkeiten zirkulierenden Tumorzellprodukten gewann in den letzten Jahren stetig an Aufmerksamkeit. Sie wird unter dem Begriff Flüssigbiopsie (Liquid Biopsy, LB) zusammengefasst. In diesem Beitrag werden die wichtigsten LB-Analyten vorgestellt sowie die noch bestehenden Hürden und vielfältigen Bemühungen der Implementierung der LB in die klinische Routine diskutiert.
High Throughput Newborn Screening for Sickle Cell Disease –
Application of Two-Tiered Testing with a qPCR-Based Primary
screen
Authors: Janda Joachim , Hegert Sebastian , Bzdok Jessica , Tesorero Rafael , Holtkamp Ute , Burggraf Siegfried , Schuhmann Elfriede , Hörster Friedrike , Hoffmann Georg F. , Janzen Nils , Okun Jürgen G , Becker Marc , Durner Jürgen
Published: September 2023

Background Sickle cell disease (SCD) is a group of hemoglobinopathies with
a common point mutation causing the production of sickle cell hemoglobin (HbS).
In high-throughput newborn screening (NBS) for SCD, a two-step procedure is
suitable, in which qPCR first pre-selects relevant samples that are
differentiated by a second method.

Methods Three NBS centers using qPCR-based primary screening for SCD
performed a laboratory comparison. Methods using tandem MS or HPLC were used for
differentiation.

Results In a benchmarking test, 450 dried blood samples were analyzed.
Samples containing HbS were detected as reliably by qPCR as by methods
established for hemoglobinopathy testing. In a two-step screening approach, the
2nd-tier-analyses have to distinguish the carrier status from
pathological variants. In nine months of regular screening, a total of 353,219
samples were analyzed using two-stage NBS procedures. The 1st-tier
screening by qPCR reduced the number of samples for subsequent differentiation
by>99.5%. Cases with carrier status or other variants were
identified as inconspicuous while 78 cases with SCD were revealed. The derived
incidence of 1:4,773, is in good agreement with previously published
incidences.

Conclusion In high-throughput NBS for SCD, qPCR is suitable to focus
2nd-tier analyses on samples containing HbS, while being
unaffected by factors such as prematurity or transfusions. The substantial
reduction of samples numbers positively impacts resource conservation,
sustainability, and cost-effectiveness. No false negative cases came to
attention.
Palliativmedizinische Versorgung durch Spezialisierte Palliativteams
– SAPV im Jahr 2023
Authors: Joist Thomas , Joist Regine , Wagner Stefanie , Wille-Friederichs Annette
Published: September 2023

Die palliativmedizinische Versorgung im ambulanten Bereich ist heute wesentlicher
und integraler Bestandteil der Begleitung schwerstkranker und sterbender
Patienten. Die Versorgung erfolgt – die individuellen
Bedürfnisse des Patienten berücksichtigend – in
verschiedenen miteinander verbundenen Stufen. Multiprofessionalität und
ständige Verfügbarkeit für die Patienten sind
wesentliches Kennzeichen der spezialisierten ambulanten Palliativversorgung
(SAPV). Die meisten der in der SAPV betreuten Patienten leiden an einer
onkologischen Erkrankung. Deshalb ist die Verbindung von SAPV und Onkologie sehr
eng. Die Zusammenarbeit mit eigenständigen SAPV-Teams sollte
frühzeitig erfolgen, um einen Verbleib und auch ein Versterben zu Hause
sicherzustellen. Denn dies entspricht dem überwiegenden Wünschen
unserer Patienten.
Endoscopic ultrasound-guided perivascular pancreatic radiofrequency ablation using a hydroxyethyl starch solution prior to pancreatectomy
Authors: Montanelli Julieta , Sosa-Valencia Leonardo , Badaoui Abdenor , Averous Gerlinde , Swanstrom Lee , Mutter Didier , Pessaux Patrick , Seeliger Barbara
Published: September 2023

Background and study aims Pancreatic surgery remains complex,
particularly for borderline resectable and locally advanced tumors. Vascular invasion
compromises resectability, and vascular resection entails increased morbidity and mortality.
Following a feasibility and safety demonstration of augmented endoscopic ultrasound
(EUS)-guided radiofrequency ablation (RFA) using hydroxyethyl starch (HES) in porcine
pancreatic parenchyma, the present study assesses whether this approach (EUS-sugar-RFA) in the
pancreatic perivascular space is safe and creates a controllable margin of necrosis to enable
a vessel-sparing resection.

Methods EUS-sugar-RFA in the pancreatic parenchyma adjacent to
the splenic artery and vein was performed in a live animal model. Following different survival
periods (0–4 days) in the interventional group (n = 3), open pancreatectomy was carried out.
The control group (n = 4) included open pancreatectomies in two pigs with non-treated
pancreases and in two with pancreatic RFA alone on the same day.

Results All procedures were completed successfully, without
intraoperative or postoperative complications. Survival periods were uncomplicated.
Histopathological examination showed local necrosis and inflammatory reaction at the ablation
sites. Vascular wall integrity was preserved in all specimens. The untreated pancreatic zones
in the interventional group were no different from the normal pancreases in the control
group.

Conclusions Preoperative perivascular augmented RFA using HES was
safe, and in the pancreatic animal model, the best timeframe was within 24 hours before
pancreatic surgery. This technique might improve resectability in selected borderline and
locally advanced pancreatic cancers.
Long-term results after EUS gallbladder drainage in high-surgical-risk patients with acute cholecystitis: A 3-year follow-up registry
Authors: Martinez-Moreno Belen , López-Roldán Gonzalo , Martínez-Sempere Juan , de-Madaria Enrique , Jover Rodrigo , Aparicio José Ramón
Published: September 2023

Background and study aims Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) has become the favorite drainage option for high surgical-risk patients with acute cholecystitis. However, data on long-term outcomes regarding efficacy and security over 1 year are scarce.

Patients and methods We performed a retrospective review of a prospectively maintained database to analyze the 3-year long-term outcomes of EUS-GBD with lumen apposing metal stents (LAMS) in high-surgical-risk patients with acute cholecystitis.

Results Fifty patients with acute cholecystitis who underwent
EUS-GBD with LAMS and 3-year follow-up or until death were included in this study. No
endoscopic revisions were scheduled unless an adverse event (AE) or suspected LAMS dysfunction
occurred. AEs occurred in 18%, 20%, and 26% of patients in the first, second, and third years,
respectively. Thirteen patients developed at least one AE, and six presented with a second AE
during follow-up. Recurrence of cholecystitis occurred in two patients (4%). Seven stent
migrations (14%) occurred but all were asymptomatic. Symptomatic LAMS-related AEs (LAMS-RAEs)
(37.5%) were related to gastric location of the stent compared with duodenal location (66.7%
vs. 12.5%, P = 0.03). No stent-related bleeding or stent-related
mortality was observed.

Conclusions EUS-GBD with LAMS without scheduled removal is an effective and safe long-term treatment in high-surgical-risk patients with acute cholecystitis. Late LAMS-RAEs tend to be more asymptomatic over time. Symptomatic LAMS-RAEs are associated with gastric location, and overall, AEs tend to recur.
Duodenal neuroendocrine tumors: Short-term outcomes of endoscopic submucosal dissection performed in the Western setting
Authors: Gupta Sunil , Kumar Puja , Chacchi Rocio , Murino Alberto , Despott Edward J , Lemmers Arnaud , Pioche Mathieu , Bourke Michael J.
Published: September 2023

Background and study aims Endoscopic resection (ER) is recommended for the management of duodenal neuroendocrine tumors (D-NETs) confined to the submucosal layer, without lymph node or distant metastasis. While this is accepted practice for lesions < 10 mm, consensus for larger lesions remains unclear. Although endoscopic submucosal dissection (ESD) has been proposed as the preferred ER technique for DNETs ≥10 mm, there are limited data on efficacy and safety, particularly in the Western setting.

Patients and methods We performed a retrospective analysis of patients with D-NETs who underwent ESD between 2012 and 2022 in three tertiary referral centers in Australia, France, and Belgium.

Results Fourteen patients with 15 D-NETs were evaluated. Median patient age was 64 years (interquartile range [IQR] 58–70 years). All D-NETs were confined to the duodenal bulb. Median D-NET size was 10 mm (IQR 7–12 mm) and specimen size was 15 mm (IQR 15–20 mm). Median procedure time was 60 minutes (IQR 25–90 minutes). The rate of en bloc resection was 100%. Intra-procedural perforation occurred in four patients (26.7%), with all closed endoscopically without long-term sequelae. There were no episodes of clinically significant bleeding. No local recurrence, lymph node or distant metastasis was observed at a median follow-up of 19.9 months (IQR 10.3–49.3 months).

Conclusions In experienced hands, ESD for D-NETs can achieve a 100% en bloc resection rate. There were no cases of local recurrence or distant metastatic spread, indicating that ESD may be a viable option for patients with D-NETs 10 to 15 mm that are not surgical candidates.
Bone Tissue in Magnetic Resonance Imaging: Contribution of New Zero Echo Time Sequences
Authors: Vuillemin Valérie , Guerini Henri , Thévenin Fabrice , Sibileau Elodie , Corcos Gabriel , Khaled Wassef , Zeitoun Frédéric , Morvan Gérard
Published: September 2023

The introduction of new ultrashort and zero echo time (ZTE) sequences is revolutionizing magnetic resonance imaging (MRI) and optimizing patient management. These sequences acquire signals in tissues with very short T2: mineralized bone, cortical bone, and calcium deposits. They can be added to a classic MRI protocol. ZTE MRI provides computed tomography–like contrast for bone.
Ankyloglossia: Typical Characteristics, Effects on Function, and Clinical Implications
Authors: Kummer Ann W.
Published: September 2023

The purpose of this article is to (1) define the diagnostic characteristics of ankyloglossia, (2) identify potential problems associated with ankyloglossia, and (3) discuss treatment options, when treatment is appropriate. This article is based on a review of the literature, including recent systematic reviews, and the author's experience as a cleft and orofacial specialist. Ankyloglossia is a common congenital condition characterized by an anterior attachment of the lingual frenulum on the tongue. This causes difficulty elevating and/or protruding the tongue tip. As such, ankyloglossia has been thought to affect neonatal feeding, speech, and other functions. Although systematic reviews have concluded that most infants with ankyloglossia can be fed normally, a small percentage of affected infants will show improved efficiency of feeding post-frenotomy. They also concluded that frenotomy may relieve nipple pain in the breastfeeding mothers of affected infants. Regarding speech, the systematic reviews concluded that there is no evidence that ankyloglossia causes speech disorders. This may be because simple compensations will result in normal acoustics of the sounds. Therefore, frenotomy should be recommended sparingly for newborn infants, and it should rarely, if ever, be recommended for speech disorders.
Reproductive Health of Women with Epilepsy in India: An Observational Study
Authors: Kumar Aadithya Narayan Sunil , Aghoram Rajeswari , Keepanasseril Aneesh , Nair Pradeep P.
Published: September 2023

Objectives Women with epilepsy (WWE) have special reproductive health needs. We compare menstrual disorders, obstetric outcomes, and patterns of contraceptive use among WWE in the reproductive age group to those without epilepsy.

Methods Sixty WWE between the ages of 18 and 45 years were randomly selected from a hospital database, and 60 controls in the same age group were recruited from among their families or close contacts. A questionnaire adapted from the National Family Health Survey 5 (NFHS-5) was administered to collect data on menstrual patterns, obstetric outcomes, fertility preferences, and contraceptive use. Descriptive statistics were used. Graphical and cross-tabulations were used for comparisons. All statistics were performed on STATA version 14.2 (StataCorp, Texas, United States).

Results The demographic characteristics including mean age, education, and occupational status were comparable. Dysmenorrhea requiring use of pain killers was more common among WWE (odds ratio [OR]: 3.01; 95% confidence interval [CI]: 1.11–8.72); other menstrual disorders were equally frequent. Spontaneous fetal loss was seen in 25 (21.9%) of 114 pregnancies in WWE and 22 (17.9%) of 123 among control women. Demand for family planning was satisfied in 21 (65.6%) of 32 eligible WWE and 23 (62.2%) of 37 controls with the most common method being female sterilization. WWE knew fewer methods of contraception compared with controls (median: 2; interquartile range [IQR]: 1.2 vs. 4; IQR: 2.5; p < 0.0001).

Conclusion WWE had more dysmenorrhea and less knowledge of contraceptive methods compared with controls. Abnormal uterine bleeding, contraceptive use, and spontaneous fetal loss were similar in both groups.
Applications and Reliability of Dorsal Metacarpal Artery Perforator Flap
Authors: Jayachandiran Anand Prasath , Rajendran Suresh , Mahipathy Surya Rao Venkata , Durairaj Alagar Raja , Sundaramurthy Narayanamurthy , Ananthappan Manoj
Published: September 2023

Dorsal metacarpal artery perforator flap (DMAP), first described by Quaba and Davison, is a useful tool in the armamentarium of plastic surgeons. It provides like for like tissue for the reconstruction of dorsal finger defects. It is a simple and relatively easy flap to harvest with minimal donor site morbidity. In this case series, we present our experience, applications, and surgical technique of flap harvesting.
Internal Quality Control in Hemostasis Assays
Authors: Reilly-Stitt Christopher , Jennings Ian , Kitchen Steve , Walker Isobel D.
Published: September 2023

Internal quality control (IQC) for routine and specialist hemostasis testing represents a mandatory requirement for assays offered by clinical laboratories under International Organization for Standardization, Code of Federal Regulations, and Clinical and Laboratory Standards Institute standards. The underlying principle is that regular IQC audits the analytical performance of automated, semiautomated, and manual methods. This review investigates IQC practices, including benefits, limitations, frequency per time period or batch, sources of material used, primary supplier, third party or in-house, plus troubleshooting when IQC falls outside acceptance criteria. To assess IQC practice, the UK National External Quality Assessment Scheme (NEQAS) Blood Coagulation distributed a questionnaire to 1,200 participants enrolled in our scheme that collected details of the local practices for IQC testing. We received returns from 127 centers that described their local practices for the frequency of IQC, the type of IQC material employed, acceptance criteria for IQC data, and troubleshooting protocols for IQC failures. The data collected as part of an NEQAS BC questionnaire confirmed that all the participants returning answers to the questionnaire meet the standards for regular IQC testing for the hemostasis assays they perform.
Role of a Plastic Surgeon in the Management of Local Manifestations of Snakebite in a Tertiary Care Hospital: A Prospective Single-Center Case Series
Authors: Mohsin Mir , Zargar Haroon Rashid , Yasir Mir , Kaul Ankush , Sharma Bunny , Wani Adil Hafeez
Published: September 2023

Background There is a paucity of literature regarding the management of snakebite site complications. The wound complications can have debilitating sequelae, most of which may require reconstruction.

Methods This is a prospective single-institution observational study conducted from November 2019 to December 2021. Patient demographic characteristics and snakebite-related information, length of hospitalization, surgical lesions encountered, the type of treatment offered, and complications were recorded.

Results Fifteen patients (10 males and 5 females) with ages ranging from 10 to 53 years (mean: 36.5 years) were included in the study. Urgent fasciotomy was performed in three patients with compartment syndrome of the upper limb. Facial reconstruction was performed in one patient. One patient required distraction, cross-finger flap, and bone grafting of the index finger, while another patient required a pedicled groin flap for digital salvage. Below knee amputation was done for Marjolin's ulcer in a chronic snakebite case. Few patients required skin grafting. No major complications were encountered.

Conclusions Plastic surgeons play an important role in the management of bite site effects for restoration of form and function, which goes a long way in rehabilitating these patients back in the society. This case series presents a varied range of bite site complications and their management that would serve as a guide to plastic surgeons for better outcome.
Induction Chemotherapy for Sinonasal Tumors in Patients Presenting with Brain Invasion and/or Neurological Deficits
Authors: Brahimaj Bledi C. , Contrera Kevin J. , Rubino Franco , Almeida Romulo Andrade de , Ferrarotto Renata , Phan Jack , Su Shirley Y. , Hanna Ehab Y. , DeMonte Franco , Raza Shaan M.
Published: September 2023

Objective The aim of this study was to investigate the safety of induction chemotherapy (IC) for patients with sinonasal malignancies with brain invasion or a neurological deficit.

Methods We conducted a retrospective analysis of patients who underwent IC for sinonasal malignancies with intracranial invasion or a neurological deficit at a single tertiary cancer center from 1992 to 2020.

Results In total, 460 patients with sinonasal malignancies were included in the study. Of the patients reviewed, 341 underwent IC and within this group 40 had brain invasion (BI) and 31 had a neurological deficit (ND) at presentation. The most prevalent malignancy was sinonasal undifferentiated carcinoma (BI 40%, ND 41.9%), followed by esthesioneuroblastoma (BI 27.5%, ND 9.7%). All tumors were stage T4 with the majority lacking nodal metastases (BI N0: 72.5%, ND N0: 77.5%). All patients completed at least two cycles of IC. Partial or complete response to IC was seen in 80% of BI and 71% of ND patients. No patients had cessation of treatment due to neurologic decline and none required urgent surgery. Five patients (12.5%) with BI and 2 (6.5%) with ND had interruption of IC for reasons other than neurological decline. In patients with ND, IC led to improvement of 54.5% NDs.

Conclusion In patients with sinonasal malignancies with BI or ND who underwent IC, no patients had cessation of treatment due to neurologic decline. In contrast, most patients had improvement of neurologic symptoms with IC. IC was safely administered without interruption due to neurological decline or symptom progression.
What Role Does Microthrombosis Play in Long COVID?
Authors: Iba Toshiaki , Connors Jean M. , Levy Jerrold H.
Published: September 2023

Soon after the outbreak of coronavirus disease 2019 (COVID-19), unexplained sustained fatigue, cognitive disturbance, and muscle ache/weakness were reported in patients who had recovered from acute COVID-19 infection. This abnormal condition has been recognized as “long COVID (postacute sequelae of COVID-19 [PASC])” with a prevalence estimated to be from 10 to 20% of convalescent patients. Although the pathophysiology of PASC has been studied, the exact mechanism remains obscure. Microclots in circulation can represent one of the possible causes of PASC. Although hypercoagulability and thrombosis are critical mechanisms of acute COVID-19, recent studies have reported that thromboinflammation continues in some patients, even after the virus has cleared. Viral spike proteins and RNA can be detected months after patients have recovered, findings that may be responsible for persistent thromboinflammation and the development of microclots. Despite this theory, long-term results of anticoagulation, antiplatelet therapy, and vascular endothelial protection are inconsistent, and could not always show beneficial treatment effects. In summary, PASC reflects a heterogeneous condition, and microclots cannot explain all the presenting symptoms. After clarification of the pathomechanisms of each symptom, a symptom- or biomarker-based stratified approach should be considered for future studies.
An Unusual Presentation of Noma: A Case Report
Authors: Khan Dr. Arshad H. , Khan Prof. Masood H. , Masood Dr. Asif , Ahmad Dr. Khursheed
Published: September 2023

A rare case of loss of palate (Soft & hard including the premaxilla) and total loss of nasal septum (cartilagenous and bony) occurring in childhood (6 years age) during the course of exanthematous fever (Small pox) is presented.
Non-Giant Congenital Melanocytic Naevus in Eyelid-A Case Report
Authors: Gahankari Dr. Dilipkumar , Lalwani Dr. Nimmi , Desai Dr. Sangita , Gandhi Dr. Dhaval
Published: September 2023

Non-giant congenital melanocytic naevus is a rare entity. A case of such naevus in lower eyelid in a eight months old female child is presented. The lesion is completely excised and lower eyelid reconstruction is performed with Mustarade's cheek advancement rotation flap. Rairty of incidence and the possibility of its undergoing malignant changes is discussed.
Supply chain myths in the resilience and deglobalization narrative: consequences for policy
Authors: Thakur-Weigold Bublu , Miroudot Sébastien
Published: September 2023

The economic disruptions experienced during the COVID-19 pandemic and Russia’s invasion of Ukraine have generated a narrative of resilience and deglobalization that brings the old world order into question. Heightened public attention on perceived supply chain failures has exerted pressure on governments to intervene in firm-level operations to assure supply of essential or strategic goods. This paper argues that the narrative is founded on false premises. In particular, three supply chain myths have emerged in public and academic discourse: (i) lean management has gone too far and exacerbated disruptions in global supply chains; (ii) efficient supply chains are less resilient; and (iii) foreign supply makes supply chains less resilient. We argue that these beliefs are not adequately supported by evidence. They can displace analysis to negatively impact policy and actually diminish resilience. Drawing upon IB and supply chain management research, we investigate the root causes of perceived market failures. Recommendations are for an evidence-based debate on current events and policies.
Global anomalies and bordism invariants in one dimension
Authors: Koizumi Saki
Published: September 2023

We consider massless Majorana fermion systems with G=ZN, SO(N), and O(N) symmetry in one-dimensional spacetime. In these theories, phase ambiguities of the partition functions are given as the exponential of the η-invariant of the Dirac operators in two dimensions, which is a bordism invariant. We construct sufficient numbers of bordism invariants to detect all bordism classes. Then, we classify global anomalies by calculating the η-invariant of these bordism classes.
On low rank fusion rings
Authors: Vercleyen G. , Slingerland J. K.
Published: September 2023

We present a method to generate all fusion rings of a specific rank and multiplicity. This method generated exhaustive lists of fusion rings up to order 9 for several multiplicities. We introduce a class of non-commutative fusion rings based on a group with transitive action on a set. This construction generalises the Tambara–Yamagami (TY) and Haagerup-Izumi (HI) fusion rings. We give an example of two such rings that are categorifiable and not of TY or HI type. The structure of non-commutative fusion rings with a subgroup is reviewed, and the one- and two-particle extensions of groups are classified. A website containing data on fusion rings is introduced, and an overview of a Wolfram Language package for working with these rings is given. We also applied several categorifiability criteria to the fusion rings. We provide a table of all multiplicity-free fusion rings up to rank 9 with info on the categorifiability of each ring.
Experimental study of boiling heat transfer characteristics of forced flow in annular tube under negative pressure
Authors: Wang Shaohua , Jin Lei , Guo Jiachao , Tian Xiaoliang
Published: September 2023

In order to investigate the recycling technology for efficiently recovering low-temperature wastewater waste heat from industrial production, we built an experimental device for forced boiling heat transfer in an annular tube. This paper takes a ring casing evaporator with an inner tube diameter of 30 mm, a length of 1450 mm, a wall thickness of 0.8 mm, and an outer tube diameter of 14.2 mm, which was used as the main object of study. We conducted experimental research on heat transfer in single-phase liquid flow and two-phase boiling phase change within annular tubes by varying the inlet circulating hot water temperature (60–85 °C), the mass flow rate of the circulating mass (0.85, 1.27, 1.69 kg m−2 s−1), and the inclination angle (0°–90°). The research results indicate that the heat transfer coefficient of boiling phase change within annular sleeves is significantly enhanced compared to convective heat transfer of single-phase liquid flow within annular tubes. This signifies that employing heat pipe technology for waste heat recovery can achieve highly efficient heat transfer processes. This study also reveals that with an increase in the inclination angle, the heat transfer coefficient on the boiling surface follows a trend of initial increase followed by a decrease. Near an inclination angle of 30° within the annular jacket tube, the heat transfer coefficient of two-phase boiling phase change reaches its maximum value. The findings of this study provide certain theoretical guidance for the application of heat pipe energy-saving technology in the field of medium- and low-temperature waste water recovery and utilization.
Analytical refractory period distribution for a class of time-variant biochemical systems with second-order reactions
Authors: Rao Changqian , Lin Wei , Song Zhuoyi
Published: September 2023

Refractory period (RP), the waiting time between signals, can induce complex signaling dynamics, such as acceleration, adaptation, and oscillation, within many cellular biochemical networks. However, its underlying molecular mechanisms are still unclear. Rigorously estimating the RP distribution may be essential to identify its causal regulatory mechanisms. Traditional methods of estimating the RP distribution depend on solving the underlying Chemical Master Equations (CMEs), the dominant modeling formalism of biochemical systems. However, exact solutions of the CME are only known for simple reaction systems with zero- and first-order reactions or specific systems with second-order reactions. General solutions still need to be derived for systems with bimolecular reactions. It is even more challenging if large state-space and nonconstant reaction rates are involved. Here, we developed a direct method to gain the analytical RP distribution for a class of second-order reaction systems with nonconstant reaction rates and large state space. Instead of using the CME, we used an equivalent path-wise representation, which is the solution to a transformed martingale problem of the CME. This allowed us to bypass solving a CME. We then applied the method to derive the analytical RP distribution of a real complex biochemical network with second-order reactions, the Drosophila phototransduction cascade. Our approach provides an alternative to the CMEs in deriving the analytical RP distributions of a class of second-order reaction systems. Since the bimolecular reactions are common in biological systems, our approach could enhance understanding real-world biochemical processes.
An efficient MSM UV photodetector with an ultra-low dark current enhanced by a back to back TiO2/PbTiO3 PN heterojunction
Authors: Zhang Yupeng , Zhou Ruiheng , Ruan Shengping , Ma Yan , Liu Caixia , Chen Yu , Zhou Jingran
Published: September 2023

A TiO2 MSM UV photodetector has been extensively researched and exhibits many good properties such as stability and a large ratio of light to dark current. However, it suffers from a high dark current and slow response and recovery. In this work, an MSM UV photodetector based on a TiO2/PbTiO3 heterojunction was fabricated by a sol-gel method. Spontaneous polarization of ferroelectric perovskite PbTiO3 can deplete carriers and accelerate the separation and transport of photo-generated carriers. The photodetector showed enhanced performances, including an ultra-low dark current (1.146 19 × 10−11 A), an improving ratio of light to dark current, as well as short response and recovery times (decreasing to 65 and 81 ms). These results indicate the potential in the combination of ferroelectric perovskite PbTiO3 with traditional wide bandgap semiconductor materials to fabricate high-performance UV photodetectors.
Sources of error and methods to improve accuracy in interface state density analysis using quasi-static capacitance–voltage measurements in wide bandgap semiconductors
Authors: Rummel B. D. , Cooper J. A. , Morisette D. T. , Yates L. , Glaser C. E. , Binder A. T. , Ramadoss K. , Kaplar R. J.
Published: September 2023

Characterizing interface trap states in commercial wide bandgap devices using frequency-based measurements requires unconventionally high probing frequencies to account for both fast and slow traps associated with wide bandgap materials. The C−ψS technique has been suggested as a viable quasi-static method for determining the interface trap state densities in wide bandgap systems, but the results are shown to be susceptible to errors in the analysis procedure. This work explores the primary sources of errors present in the C−ψS technique using an analytical model that describes the apparent response for wide bandgap MOS capacitor devices. Measurement noise is shown to greatly impact the linear fitting routine of the 1/CS∗2 vs ψS plot to calibrate the additive constant in the surface potential/gate voltage relationship, and an inexact knowledge of the oxide capacitance is also shown to impede interface trap state analysis near the band edge. In addition, a slight nonlinearity that is typically present throughout the 1/CS∗2 vs ψS plot hinders the accurate estimation of interface trap densities, which is demonstrated for a fabricated n-SiC MOS capacitor device. Methods are suggested to improve quasi-static analysis, including a novel method to determine an approximate integration constant without relying on a linear fitting routine.