bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Hippocampal Cell Death and Memory Deficits in Rats Following Neonatal Stress
Authors: Ghanimi Hussein A. , Albahadly Waleed Khaled Younis , Abdolmaleki Arash , Roohbakhsh Ali , Zaniani Nosaibeh Riahi
Published: May 2022

Objective: Neonatal stress (NS) has harmful effects on the hippocampal neurons of rat neonates. It has been reported to enhance neuronal cell death and impair memory behaviors. The researchers conducted this study in order to assess NS’s effects on hippocampal apoptosis and memory deficits in rat neonates’ hippocampus. Methods: Three groups of male Wistar rat neonates exposed to NS; rat neonates reared with 1 hour neonatal isolation (NI) for 8 consecutive days (P2-P9), rat neonates exposed to febrile seizure (FS) at day 10 (P10) and rat neonates reared with both NI plus FS (NI-FS). Control group was reared normally. Novel object recognition test (NORT) carried out to evaluate the effects of NI, FS and NI-FS on memory deficits. At day 22 (P22), Terminal deoxynucleotidyl transferase- mediated dUTP nick end labeling (TUNEL) assay was done. Results: NORT demonstrated that rat neonates exposed to NI-FS had short-term and long-term memory deficits (P<0.01 and P<0.001). Rat neonates experienced NI had long-term memory deficits (P<0.05). TUNEL assay results showed that NI-FS increased the count of hippocampal apoptotic neurons in Cornu Ammonis 1 (CA1), Cornu Ammonis 3 (CA3) and dentate gyrus (DG) subfields (P<0.001, P<0.001 and P<0.001). Also, NI increased the count of hippocampal TUNEL positive cells in CA3 and DG subfields (P<0.05 and P<0.01). In addition, FS increased the count of hippocampal apoptotic neurons in DG subfield (P<0.05). Conclusion: The present results showed that NS exerted apoptotic effect and induced memory deficits in the hippocampus of rat neonate.
Antioxidant Impact of Green Synthetized Magnetic Nanoparticle of Nigella Sativa Seed Alcoholic Extract in Male Rats
Authors: Habeeb Zahraa Mohammed , Jari Salim Hussein
Published: May 2022

That experience was conducted for the purpose of known the impact antioxidant nanoparticles of Nigella sativa agonist oxidative stress of the Nanoparticles the iron in rats. The experience was conducted in veterinary medicine Al-Qadisiya university at the animal house. This study was carried out during a period from 20.11.2020 to 20.04.2021 (64) sixty four mature rat 90 days age. Wister rat average body weight (100-120) gram will be used in the preset study the rat will be kept under controlled hygienic condition with free access to food and water for two week before starting the experiment. The animal will be randomly assigned into 4equal groups 16 each and treated as follow. The following objective will be studied. Gene expression examination in 14 and 28 days. added Evaluation of liver alanine aminotransferase ALT and the alkaline phosphatase ALP, AST aspartate amino transferase gene expression level, And GSS (glutathione) and Sod 1(superoxide dismutase) gene expression. When gave mix groups (Nigella sativa and Iron) to male rats significant decrease fold change gene expression level compared with control groups. While gave Nigella sativa alone to male rats significant decease fold change (gene expression level) compared with control groups. Iron alone gave to male rats increase significant e fold change gene expression level compared with control group. Gene expression (fold change) (glutathione) and Sod 1(superoxide dismutase) gene expression. Examination in 14 and 28 days gave significant increase in mix group and Nigella sativa, significant decrease in Iron group.
Digital Competences and Teaching Performance in Regular Basic Teachers of Lima
Authors: Llamosa Maria Ysabel Valentin , Relaiza Hector Raul Santa Maria , Moreno Giancarlo Roosvelt Contreras , Garcia Ulises Cordova , Caceres Marina Vilca
Published: May 2022

The purpose of the research was to determine the relationship between digital skills and teaching performance in an educational institution in Lima. It was developed under the quantitative approach, type of basic research, nonexperimental cross-sectional design, descriptive correlational. Regarding the sample, it was made up of 57 teachers from the secondary level of said study center; The field work was developed through the survey and instrument technique, questionnaires from which a high reliability was obtained through the Cronbach's Alpha of digital skills (0.903) and teaching performance (0.871). A very high positive correlation (0.926) between the variables was determined by the bilateral significance of (0.000). There is evidence of a significant relationship between digital skills and teaching performance in an educational institution in Lima; therefore, the use of technology is pertinent in the work of the teacher, since the empowerment of digital skills was achieved in them, in addition to being at the forefront of the demands of the competitive world that demands more and more teachers prepared to train citizenship competencies and achieve the student's graduation profile at the end of regular basic education.
Virtual Education and Professional Development in Teachers of UGEL 15, Huarochiri - Lima
Authors: Ostos Dennis Fernando Jamillo , Condori Felipe Supo , Panduro Bernardo Céspedes , Ccanto Florencio Flores , Centellas Yudy Yaneth Tapia
Published: May 2022

The objective of this article is to determine the relationship between digital skills and professional development in teachers at UGEL 12, Canta. The study was of type, of correlational-causal design, it is non-experimental and crosssectional since the phenomena were observed in their natural state and the data collection was carried out in a single moment. The survey technique was used to measure the variables, likewise a questionnaire was used as an instrument for each variable, for the quantitative variable digital skills a 32-item questionnaire was used considering three dimensions; In relation to the professional development variable, a 33-item questionnaire was used, which includes three dimensions: time organization (12 items), planning (9 items) and the virtual resources dimension (15 items). The population was 450 teachers, the inclusion criteria were the teachers who worked throughout the year 2021 in the institutions of UGEL 12, the study sample consisted of 205 teachers; According to the results obtained, a correlation coefficient of rho =.695** was obtained, demonstrating that the relationship between digital skills and professional development of teachers is positive, so it is concluded that there is a significant relationship between digital skills and professional development in teachers at UGEL 12, Canta – Lima.
An Amalgamation of Ayurveda and Evidence-based Medicines with Artificial Intelligence and Machine Learning: A Synergistic Approach for Less Expensive and Effective Diagnosis Approaches
Authors: H.M. Manjulaa , Raj Dr.S.P. Ananda
Published: May 2022

Technology plays a very important key role in various diagnosis processes. For example, capturing the patient information, maintaining the electronic health records for further diagnostic references, improving the clinical diagnosis process, and reducing diagnostic errors when technology is applied in the right ways with proper knowledge of technology. In this proposed work, the design of the integrated analysis process of Ayur’veda and Western method of diagnosis by using the current technologies such as Artificial Intelligence and Machine Learning techniques are discussed. This integration process ensures that technologies simplify the timely and accurate diagnosis process. Integration of the Ayurveda and Evidence-based western medicines has become very much necessary and important in today’s situation. But, during this process, one should not disturb the basic principles of both Indian Traditional Medicine and Evidence-based medicine. During integration, the best of best diagnosis approaches in both the fields are chosen with disease management, disease prevention, and protection which create a healthy society by developing healthcare with less expensive and less toxic. The amalgamation approach will be more effective than concentrating on just one diagnostic method.
Traditional Games in Cultural Literacy to Build the Character of Elementary School Students during the COVID-19 Pandemic
Authors: Gultom Syamsul , . Baharuddin , Ampera Dina , Endriani Dewi , Jahidin Ismail , Tanjung Samsidar
Published: May 2022

Formal educational institutions are responsible for the character education of students as the next generation of the nation, for which students need to be prepared for education as early as possible to have character, as in traditional games. Along with the times, traditional children's games have shifted with modern games, namely virtual world games with advanced technology. The 21st St skills early learning framework supports the integration of skills (critical thinking, collaboration, communication, creativity, technology literacy, and socio-emotional. Traditional games have many benefits in all aspects of student development which include physical-motor, socio-emotional, moral, cognitive, and language development. Through the 2013 curriculum, it is expected to be able to provide life skills during the Covid-19 pandemic. Cultural literacy developed is very diverse, among others with traditional game literacy. The introduction and preservation of traditional game culture in addition to government support is certainly also highly expected the role of parents and the community. Play is a very important and fun activity in the child's learning process, so it will be encouraged to experiment and grow well in life. Traditional games have so many different forms and variations and tend to take advantage of tools or facilities that exist in the school environment without having to buy them so that it requires high imagination and creativity. In addition, traditional games also have noble values and certain moral messages such as the values of togetherness, honesty, responsibility, airy attitude (if lost), encouragement of achievement, and adherence to rules. All that can be done if the player really enjoys, enjoys and understands the essence of the game. By sticking to Indonesian cultural literacy has an honest identity about culture. It is hoped that the Indonesian nation can become a developed and civilized nation.
Impact of Education, Socioeconomic Status and Employment on Breast Feeding duration among Nursing Mothers
Authors: Dutt Rachana , Mahajan Payal
Published: May 2022

Breastfeeding provides a number of benefits for both newborns and mothers. In any event, despite overwhelming evidence to the contrary, the occurrence of breast-feeding care has declined sharply. From the mother, bosom milk provides abundant and efficiently swallowed healthy components, cell reinforcements, chemicals, insusceptible characteristics, and living antibodies. Breastfeeding provides a number of advantages for both newborns and moms. Despite significant evidence to the contrary, breast-prevalence feeding's has remained low across the world. The goal of this study was to see how a mother's education affected her children, socioeconomic position, and employment on the length of time she breastfed her child. The current study was conducted in Delhi to determine the impact of a mother's education, employment, and socioeconomic level Breast-feeding duration in urban and rural nursing moms. A total of 200 breastfeeding mothers from the city and 200 lactating mothers from the countryside were considered for the study. A purposeful random inspection of data technique is used and collected directly from mothers occupying a tailored survey to assess the impact of the mother's education, employment, and socioeconomic level on the length of breast feeding. Following the data collection, the data will be properly categorized and organized under numerous headings. Information and attitude were used to code. Following that, the content and quantifiable research was completed using percentages.
Analysis of Transient MHD Flow Past a Vertical Plate with Periodic Temperature
Authors: Vijayalakshmi E. Arul , M. Kannana , J. Visuvasam
Published: May 2022

A mathematical model is used to simulate the effect of the magnetic field on the temporary free convection flow of electrically conductive fluid past a vertical plate under periodic temperatures. Analyzing momentum and energy equations using homotopy perturbations. The analysis of the temperature profile with a constant temperature plate is presented using Homotopy perturbation method and Laplace transform. There is an analysis of the significance of different physical parameters, such as Grashof number, magnetic parameter, Prandtl number, and temperature frequency, on transient velocity and temperature. Additionally, the local Skin-friction and local Nusselt number coefficients are determined and analyzed.
Synthesis and Characterization of Li2MnO3 Using Sol-gel Technique
Authors: Kadhum Samah Abd , Muslim Zainab Raheem
Published: May 2022

Li2MnO3 nanoparticles were prepared using the Sol-Gel method and characterized by XRD, AFM, SEM, TGA and DSC with major peaks (18.81°), (37.10°) and (44.76°) using AfM, the average diameter of the nanoparticles was (45.71 nm). SEM was used to assess the surface morphology; The micropicture showed homogeneous spherical formations with particle sizes ranging from 2 to 4 meters. Thermal analysis was determined by TGA and DSC results showed a thermal stability from 500 to 750, indicating development of the phase. Li2MnO3 nanoparticles display excellent properties and are suitable as cathode materials in lithium-ion batteries.
Assessment of Nutritional Status Using Anthropometric Methods and Assessment of Knowledge and Attitude of Nursing Mothers towards Breast Feeding Practices
Authors: Dutt Rachana , Mahajan Payal
Published: May 2022

"Your well-being will be determined by the type of food you eat," according to a popular adage. In any case, a powerful eating regimen consists of really important upgrades in the appropriate degree. It inhibits the onset of illnesses such as obesity, diabetes, heart disease, illness, and stroke, to name a few examples. Infants and small children dealing with practices are crucial in maintaining nutritional status of children aged 0 to 2 years, who are frequently influenced by daily practices. There is a correlation between children's apparent lack of solid meals and the country's child persistence rates. It is vital for children's growth and success to focus on further improving these behaviours. During the peak period of development in the first two years of life, illness and poor health have an impact on children's advancement potential. Breastfeeding is a basic human behaviour that benefits the infant and the mother's health, as well as providing a considerable financial incentive for families and social orders. The goal of the current study was to acquire a deeper grasp of the promising findings and perspectives on breast milk among rural nursing moms. A total of 200 nursing women from the city and 200 from the rural would be included in the research. A purposeful random sampling approach was used to acquire data. The information was acquired from nursing mothers using a coordinated overview to look at their food habits and attitudes. Following data collection, processing, analysis, and the post-intervention included substantial information on breastfeeding practices and their relevance. Then, under numerous areas, their nutritional knowledge and attitude, as well as nutritional health anthropometric parameters, were examined again. To code, information and attitude were employed. The content and measurable investigation was then completed, and the operating frequency was determined.
A Canny Edge Detection Algorithm for Automatic Identification of Plant Diseases
Authors: E. Gangadevi , R. Dr. Shoba Rani
Published: May 2022

Plant diseases are important to investigate because they cause loss of plant life and product. Various forms of losses can occur in the field, in storage, or at any point between sowing and harvesting. Direct monitory loss and material loss are caused by the diseases. Plant diseases continue to cause agony to untold millions of people around the world, resulting in an estimated annual yield loss of 14% and a global economic loss of $220 billion dollars. Plants were afflicted by several diseases 250 million years ago, according to fossil evidence. The Plant sickness has been linked to a number of significant events in the Earth's history. In this paper, we have analyzed various types of diseases which affects the plants and applied some machine learning classification approaches to plant dataset. Among these classification steps, we identified the percentage of accuracy in each algorithm so that proper approach can be followed to identify the plant diseases at the earlier stage.
A STUDY OF THE BENEFITS OF STATE TOURISM ORGANIZATION COMMUNITY ENGAGEMENT AND ITS IMPACT ON AWARENESS AND VISIT INTENTION
Authors: Singh Avinash Kumar , Sharma Dr. Smita , Shekhar Mukesh
Published: May 2022

Destination marketing pertain to the development of networking on internet using various social media platforms. It proposes both prospects and challenges for the state tourist corporations (STCs). To boost their marketing adequacy and meet the demands of their partners, STCs should promote increased social-media (SM) marketing activities. The scope of the study is limited to the web page of Uttar Pradesh State Tourism Corporation. The objective of this study is to gain an insight into the benefits of page following as indicators of involvement and engagement. The study explores and investigates social-media (SM) marketing effects in terms of creating awareness and visit intention of those following the web page of STC of Uttar Pradesh Tourism, India. The sample size included visitors of official Facebook page of UP Tourism and 393 followers’ responses were chosen for this study. The results of this investigation demonstrate that social-media (SM) advantages and community engagement have a statistically significant impact on followers' knowledge and visit intentions. The study has implications for both policy and practice wherein the state tourist corporations can utilize the existing platform to assist them in developing a marketing and promotion strategy for their diverse tourist locations.
Development of Japanese Language Proficiency to Upgrade Manpower for Working Abroad
Authors: Sangsiri Jintarat
Published: May 2022

This research aims to 1) Survey the in the interest of Japan and Japanese of manpower who want to go out for work abroad in Phetchabun province and 2) To enhance the Japanese language ability to upgrade the manpower to go to work abroad in Phetchabun Province. The research sample consisted of 15 people in Phetchabun province who were about to go out for working abroad. The research instruments were 1) a test of Japanese language consisting of 30 multiple-choice test items for pre-testing and post-testing 2) a questionnaire on the interest of the manpower in Phetchabun province who were about to go out for working abroad, and 3) six online Japanese language lessons. Data were statistically analyzed using the mean, standard, and t-test. The results of the research showed that 1. Regarding interest information of the about to work aboard manpower in Phetchabun province, there are opinions about the importance of the Japanese language in which the opinions on the roles and importance of the Japanese language to work in foreign countries are at a high level ( = 3.81, S.D. = 0.89) 2. Japanese language ability of the sample group before studying the Japanese language online content consisting of 6 lessons. The average score of the Japanese language proficiency test of the sample group before the study of Japanese online content was 50.89 points, which is higher than the average of the 6 points before the study of Japanese language content which is equal to 24.23 points and the average difference between the after and before the study of the 6 Japanese lessons equal to 24.23 points (Sig.=0.000 < 0.01) indicating that the knowledge on the Japanese language of the sample group after the experiment was significantly higher than that before the experiment with statistical significance of 0.01.
METHOD AND PRINCIPLE OF MARITIME BOUNDARY DELIMITATION BETWEEN STATES WITH OPPOSITE OR ADJACENT COASTS (CASE OF INDONESIA AND TIMOR-LESTE)
Authors: Jaya Belardo Prasetya Mega , Cahyani Ferina Ardhi , Idris Idris , Permata Rika Ratna
Published: May 2022

In the practice the maritime boundary delimitations can cause the overlap of claims between states with opposite or adjacent coasts. Regarding the maritime boundary between Indonesia and Timor-Leste, there was never a maritime boundary between both States, so it needs a settlement of disputes of maritime boundary delimitation between both parties. Therefore, these research aims to explain the methods and principles that could be used in resolving maritime boundary delimitation dispute between state with opposite or adjacent coasts based on international law and analyze how obstacles and solution to solve maritime boundary delimitation dispute between Indonesia and Timor-Leste (East Timor). This research uses normative legal research and Empirical Research Methods. The results of the research show that: (1) the maritime boundary delimitation between Indonesia and Timor-Leste uses enclaving, equidistant, and three-step approach method. (2), Indonesia and Timor Leste have the potential to determine maritime boundaries in the three areas, namely the area to the north of the Oecusse (Ombai Strait), to the north of Timor Island (Wetar Strait) and to the south of Timor Island (Timor Sea). Timor-Leste will still get a maritime territory in District Oecusse but the extent would be negotiated with Indonesia first, while in the Wetar Strait, the territorial sea division of the two countries would consider the outer islands of both countries.
THE URGENCY OF ELECTRONIC KNOW YOUR CUSTOMER (E-KYC): HOW ELECTRONIC CUSTOMER IDENTIFICATION WORKS TO PREVENT MONEY LAUNDERING IN THE FINTECH INDUSTRY
Authors: Ghozi Ahmad
Published: May 2022

The development of the Financial Technology (FinTech) Industry in Indonesia is very rapid. Financial Technology (FinTech) can generally be defined as an industry that combines technology and financial features as its business model. One of the advantages FinTech business is the speed and convenience for parties to conduct transactions. The speed and simplicity of transactions in the FinTech business are due to the use of technology in the financial services provided. Furthermore, the FinTech industry facilitates parties to conduct non-face-to-face transactions. The advantages offered by the FinTech industry raise concerns that this business could be used by criminals to commit money laundering crimes. This research tries to see the vital role of using Know Your Customer (KYC) customer principles which are carried out electronically to be applicable in preventing FinTech businesses from being used as a means of committing money laundering crimes.
Learning technology acceptance and continuance intention among business students: The mediating effects of confirmation, flow, and engagement
Authors: Tseng Hungwei , Yi Xiang , Cunningham Brent
Published: May 2022

The emergence of mobile applications has opened the door to a new kind of information and communication technology tool and educational support which is vital for students’ positive learning behaviours. The aims of this study were to examine the effects of three mediators (confirmation, flow, and student engagement) on students’ learning technology acceptance and information systems continuance intention, and to explore the functions of these variables in the mediating process between learning technology acceptance and continuance intention. Using PROCESS macro program where the bootstrap confidence interval was adopted, a parallel multiple mediation model and a serial multiple mediation model were tested. Two of the three proposed hypotheses were supported. Business students’ confirmation and flow, elicited by the m-learning app, were two mediating factors with high ratios (0.6655, 95% CI = 0.2635 to 0.6085) of the overall indirect effect to the total effect, which related to students’ decisions in continuous usages of the technology. We concluded that the continuous use of the m-learning app was driven not only by students’ flexible thinking skills in accepting new learning technology, but also by a set of cognitive attributes reflecting users’ positive experiences with the system.
Implications for practice or policy:

Business students who have positive mindsets for accepting new technology will try their best to overcome challenges of learning unfamiliar technologies.
Business students’ confirmation and flow experience elicited by the m-learning app aids in understanding of their intention to continue using the system.
Instructors must develop partnerships with instructional designers to enhance student confirmation, flow and engagement for better acceptance and continued use of mobile learning technologies.
Improving student academic emotions and learning satisfaction in lectures in a foreign language with speech-enabled language translation technology
Authors: Shadiev Rustam , Huang Yueh Min
Published: May 2022

Some students are unable to fully comprehend lecture content delivered in English as a medium of instruction (EMI) because of their low linguistic competence. This negatively impacts their academic emotions and learning satisfaction. Speech-enabled language translation (SELT) technology was applied in this study to simultaneously translate lecture content from English into native language of students and show translated text to students. This study investigated the effectiveness of a SELT application on perceived academic emotions and learning satisfaction of students attending lectures in EMI. Thirty-three university students participated, and perceived academic emotions and learning satisfaction were measured and compared across two groups of students: low language ability (LLA), and high language ability (HLA). The level of perceived academic emotions of LLA students was low before lectures but high during and after lectures. HLA students perceived high levels of academic emotions before lectures and low during and after lectures. LLA students’ level of learning satisfaction was much better in comparison to HLA students. The results suggest that SELT technology is beneficial for learning for LLA students. Therefore, educators and researchers may apply SELT technology to EMI lectures in order to facilitate LLA students levels of perceived academic emotions and learning satisfaction.
Implications for practice or policy:

SELT technology is beneficial for learning of the low linguistic competency students.
Educators and researcher may apply SELT technology to EMI lectures in order to facilitate positive academic emotions and learning satisfaction of the low linguistic competency students.
Projection-compliant database generation
Authors: Sanghi Anupam , Ahmed Shadab , Haritsa Jayant R.
Published: May 2022

Synthesizing data using declarative formalisms has been persuasively advocated in contemporary data generation frameworks. In particular, they specify operator output volumes through row-cardinality constraints. However, thus far, adherence to these volumetric constraints has been limited to the Filter and Join operators. A critical deficiency is the lack of support for the Projection operator, which is at the core of basic SQL constructs such as Distinct, Union and Group By. The technical challenge here is that cardinality
unions
in multi-dimensional space, and not mere summations, need to be captured in the generation process. Further, dependencies
across
different data subspaces need to be taken into account.

We address the above lacuna by presenting
PiGen
, a dynamic data generator that incorporates Projection cardinality constraints in its ambit. The design is based on a projection subspace division strategy that supports the expression of constraints using optimized linear programming formulations. Further, techniques of symmetric refinement and workload decomposition are introduced to handle constraints across different projection subspaces. Finally, PiGen supports dynamic generation, where data is generated on-demand during query processing, making it amenable to Big Data environments. A detailed evaluation on workloads derived from real-world and synthetic benchmarks demonstrates that PiGen can accurately and efficiently model Projection outcomes, representing an essential step forward in customized database generation.
Hippo
Authors: Shin Ahnjae , Jeong Joo Seong , Kim Do Yoon , Jung Soyoung , Chun Byung-Gon
Published: May 2022

Hyper-parameter optimization is crucial for pushing the accuracy of a deep learning model to its limits. However, a hyper-parameter optimization job, referred to as a study, involves numerous trials of training a model using different training knobs, and therefore is very computation-heavy, typically taking hours and days to finish.

We observe that trials issued from hyper-parameter optimization algorithms often share common hyper-parameter sequence prefixes. Based on this observation, we propose Hippo, a hyper-parameter optimization system that reuses computation across trials to reduce the overall amount of computation significantly. Instead of treating each trial independently as in existing hyper-parameter optimization systems, Hippo breaks down the hyper-parameter sequences into stages and merges common stages to form a tree of stages (a stage tree). Hippo maintains an internal data structure, search plan, to manage the current status and history of a study, and employs a critical path based scheduler to minimize the overall study completion time. Hippo applies to not only single studies but multi-study scenarios as well. Evaluations show that Hippo's stage-based execution strategy outperforms trial-based methods for several models and hyper-parameter optimization algorithms, reducing end-to-end training time by up to 2.76X (3.53x) and GPU-hours by up to 4.81X (6.77x), for single (multiple) studies.
Right ventricular myocardial energetic model for evaluating right heart function in pulmonary arterial hypertension
Authors: Scott Jacqueline V. , Tembulkar Tanuf U. , Lee Meng‐Lin , Faliks Bradley T. , Koch Kelly L. , Vonk‐Noordegraaf Anton , Cook Keith E.
Published: May 2022

Background

Pulmonary arterial hypertension (PAH) increases right ventricular (RV) workload and decreases myocardial oxygen reserve, eventually leading to poor cardiac output. This study created and assessed a novel model of RV work output based on RV hemodynamics and oxygen supply, allowing new insight into causal mechanisms of RV dysfunction.

Methods

The RV function model was built upon an earlier, left ventricular model and further adjusted for more accurate clinical use. The model assumes that RV total power output (1) is the sum of isovolumic and stroke power and (2) is linearly related to its right coronary artery oxygen supply. Thus, when right coronary artery flow is limited or isovolumic power is elevated, less energy is available for producing cardiac output. The original and adjusted models were validated via data from patients with idiopathic PAH (n = 14) and large animals (n = 6) that underwent acute pulmonary banding with or without hypoxia.

Results

Both models demonstrated strong, significant correlations between RV oxygen consumption rate and RV total power output for PAH patients (original model, R2 = 0.66; adjusted model, R2 = 0.78) and sheep (original, R2 = 0.85; adjusted, R2 = 0.86). Furthermore, the models demonstrate a significant inverse relationship between required oxygen consumption and RV efficiency (stroke power/total power) (p < 0.001). Lastly, higher NYHA class was indicative of lower RV efficiency and higher oxygen consumption (p = 0.013).

Conclusion

Right ventricular total power output can be accurately estimated directly from pulmonary hemodynamics and right coronary perfusion during PAH. This model highlights the increased vulnerability of PAH patients with compromised right coronary flow coupled with high afterload.
SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel
Authors: Wu Tongde , Goriounova Alexandra S. , Worthington Erin N. , Wrennall Joe A. , Ghosh Arunava , Ahmad Saira , Flori Sassano M. , Tarran Robert
Published: May 2022

Orai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that regulates gene expression, the onset of inflammation, secretion, and the contraction of airway smooth muscle (ASM). During SOCE, Ca2+ leaves the endoplasmic reticulum, which then stimulates a second, amplifying wave of Ca2+ influx through Orai1 into the cytoplasm. Short Palate LUng and Nasal epithelial Clone 1 (SPLUNC1; gene name BPIFA1) is a multi‐functional, innate defense protein that is highly abundant in the lung. We have previously reported that SPLUNC1 was secreted from epithelia, where it bound to and inhibited Orai1, leading to reduced SOCE and ASM relaxation. However, the underlying mechanism of action is unknown. Here, we probed the SPLUNC1‐Orai1 interactions in ASM and HEK293T cells using biochemical and imaging techniques. We observed that SPLUNC1 caused a conformational change in Orai1, as measured using Forster resonance energy transfer (FRET). SPLUNC1 binding also led to Nedd4‐2 dependent ubiquitination of Orai1. Moreover, SPLUNC1 internalized Orai1 to lysosomes, leading to Orai1 degradation. Thus, we conclude that SPLUNC1 is an allosteric regulator of Orai1. Our data indicate that SPLUNC1‐mediated Orai1 inhibition could be utilized as a therapeutic strategy to reduce SOCE.
Evaluation of 18 quality indicators from the external quality assurance preanalytical programme of the Spanish Society of Laboratory Medicine (SEQCML)
Authors: Caballero Andrea , Gómez-Rioja Rubén , Ventura Montserrat , Llopis María Antonia , Bauça Josep Miquel , Gómez-Gómez Carolina , Marzana Itziar , Ibarz Mercedes
Published: May 2022

Objectives

Most errors in laboratory medicine occur in the pre- and post-analytical phases of the total testing process (TTP). In 2014, the Spanish Society of Laboratory Medicine (SEQCML) started the current Preanalytical Phase EQA Programme, with the objective of providing a tool for the improvement of the preanalytical phase. The aim of this study was to review the evolution of quality indicators (QI) and the comparability of established performance specifications (PS) with other EQA programmes.

Methods

In the SEQCML programme, participants were asked to register rejections of the main specimens and the causes for rejections. Data collected from 2014 to 2017, and then reviewed biennially (2018–2019), was used to calculate the percentiles; p25, p50, p75, and p90 for every round, and their means were set as PS. These PS were compared with the results of other programmes.

Results

The evolution of QI results for 2018–2019 period showed general maintenance or improvement, e.g., a significant decrease in the number of serum samples with a haemolytic index ≥0.5 g/L, except for EDTA and citrate samples handle, maybe for an improvement in detection. The comparison with PS for the QI of the IFCC Working Group “Laboratory Errors and Patient Safety” and the Key Incident Management and Monitoring System (KIMMS) programme of the RCPA showed comparable results, supporting the validity of the established specifications.

Conclusions

The PS obtained are a helpful tool for benchmarking and to identify processes of the preanalytical phase whose improvement should be set as a priority.
Genome-wide identification and expression analysis of CPP-like gene family in Triticum aestivum L. under different hormone and stress conditions
Authors: Ullah Uzair , Buttar Zeeshan Ali , Shalmani Abdullah , Muhammad Izhar , Ud-Din Aziz , Ali Hamid
Published: May 2022

The CPP-like plant‐specific transcription factor has a prominent role in plant development and growth through cell division and differential activities. However, little information is available about the CPP gene family in Triticum aestivum L. Herein, we identified 37 and 11 CPP genes in the wheat and rice genome databases, respectively. The phylogeny of the CPP protein-like family members was further divided into five subfamilies based on structural similarities and phenotypic functional diversities. The in silico expression analysis showed that CPP genes are highly expressed in some tissues, such as shoot apex, shoot, leaf, leaf sheath, and microspore. Furthermore, the qRT-PCR found higher expression for TaCPP gene family members in leaf, leaf blade, young spike, mature spike, and differential expression patterns under abiotic stresses, including heat, drought, salt, and hormonal treatment, such as indole acetic acid and 1-aminocyclopropane-1 carboxylic acid. We found that CPP gene family members are mostly located in the nucleus after infiltrating the CPP5-1B-GFP and TaCPP11-3B-GFP into tobacco leaves. The overexpression of the TaCPP5-1D gene revealed that the CPP gene positively regulates the germanium, shoot, and root activities in Arabidopsis. The TaCPP5-1D-overexpressed plants showed less anti-oxidative sensitivity under drought stress conditions. These results demonstrated that TaCPP5-1D protein has a crucial contribution by interacting with TaCPP11-3B protein in maintaining stress homeostasis under the natural and unfavorable environmental conditions for growth, development, and stress resistance activities. Therefore, this study could be used as pioneer knowledge to further investigate the function of CPP genes in plant growth and development.
Effect of microbial-induced calcite precipitation (MICP) on the strength of soil contaminated with lead nitrate
Authors: Hadi Zahraa Samer , Saeed Khitam Abdulhussein
Published: May 2022

Microbial induced calcite precipitation method MICP is a sustainable and eco-friendly technique for soil stabilization. To show the optimum effectiveness of the bioremediation within the silty sand matrix, a model of plastic boxes and PVC molds was made with an air pump placed in an isolated room at a temperature range of 25–27°C. The molds were perforated from sides and bottoms and opened from the top with a transparent film of filter paper (placed on the inner surface). The major feature of this treatment system is allowing the cementation solution to penetrate easily into soil samples. The results showed a positive effect of Bacillus subtilis in enhancing the strength properties of lead contaminated soil. Unconfined compressive strength increased from 65 kPa to 539, 527, and 525 kPa. Cohesion increased from 4.5 to 40, 41.9, and 42 kPa at concentrations of 15, 20, and 25% respectively. Angle of internal friction increased from 18.94° to 38.2°, 40°, and 40.74° respectively after 14 days. Thereafter, it become 40.92° and 41.5° at concentrations of 15 and 20%, respectively and decreased to 36.75° of 25% at 28 days. Microstructural characteristics represent the formation of calcium carbonate and lead compounds, which were the reasons for the improvement in the strength and the alteration in lead from a soluble to insoluble form, a hence less toxic element.
From garbage to COVID-19: theorizing ‘Multilingual Commanding Urgency’ in the linguistic landscape
Authors: Chesnut Michael , Curran Nathaniel Ming , Kim Sungwoo
Published: May 2022

Across the globe signage which conveys directives regarding appropriate behavior in public, such as ‘Do Not Enter’ signs, is made multilingual in ways that other signage is not. This paper examines two examples of multilingualism in directive signs within Seoul, South Korea in order to theorize what gives rise to multilingualism in directive signage while other signage remains monolingual. Examination of Vietnamese and Arabic on signs prohibiting the illegal disposal of household garbage on side streets in Seoul, and English, Chinese, and Japanese on mask-required due to COVID-19 signs within the Seoul subway system allows for a robust analysis of what shapes the inclusion of additional languages on directive signage. We posit the construction of a differently speaking other who is seen as likely to disobey stated regulations alongside the desire by authorities to minimize the effort required to respond to rule breaking results in amultilingual commanding urgencythat shapes multilingualism in directive signage. The concept of multilingual commanding urgency emphasizes the role enforcement practices have in shaping multilingualism, an important development in understanding this form of signage. Multilingual commanding urgency is especially relevant as it shapes signage deployed in emergency contexts such as the COVID-19 pandemic.
Impact of Oil Price Shocks on MENA Countries Stock Markets: Event Study Methodology
Authors: Benbachir Saad , Harit Satt , Chraibi Assya
Published: May 2022

The purpose of this paper is to examine the linkage between a sample of six oil-importing and oil-exporting MENA countries and oil price shocks over the period 2002–2020. The event study methodology is used to examine the behavior of stock prices around an event to measure its value under the efficient market theory. The findings suggest that the dataset used and the results are robust proven by overall statistically significant results for the eight events considered. The 2008 global financial crisis had the largest impact on stock markets on the event day. The nature and duration of response are also found to vary across different events and countries. Thus the practical implications of this paper are to suggest that investors should learn to better assess oil shocks by taking into account differences in country specific policies, government effectiveness and monetary policy.
Semiotics of humor in Nigerian politics
Authors: Adegoju Adeyemi
Published: May 2022

This study explores the semiotics of humor and political disaffection in the online feedback discourse evaluating party performance in a post-election era in Nigeria’s democratic practice. It examines the incongruities in multimodal digital humor as semiotic resources of subversive play to criticize a political party for its perceived weak program-to-policy linkage. Data for the study comprise some purposively sampled political internet memes which were deployed to express political disaffection at the party All Progressives Congress (APC) in the first half (2016–2017) of its four-year (2015–2019) tenure. The study applies Algirdas J. Greimas’ semiotic theory by drawing upon the notions of narrativity and modalities to read the selected political internet memes, which run profound social commentaries on the anxieties and frustrations of the ordinary citizens in a failing economy, thereby underpinning the thrust of the theory, which lies not only in the signification of texts but also in the signification of the living experience. The study reveals the power of signs evidenced in the deployment of objects, behaviors, practices, images, and symbols within the socio-economic sub/culture of the production of the internet memes to configure backlashes of democratic deficits relating largely to worsening poverty, hunger, struggle for survival, and political cynicism in an emerging democracy.
Impact of the COVID-19 pandemic on employment and social benefit receipt in Finland
Authors: Mesiäislehto Merita , Jauhiainen Signe , Korpela Tuija , Tuori Sami
Published: May 2022

The COVID-19 crisis tested welfare states’ resilience in protecting citizens against sudden health-related and economic shocks. However, the crisis’ effects and responses to it vary substantially across countries. Using administrative registers of the Social Insurance Institution of Finland, we evaluate the impact of the COVID-19 crisis on various socio-economic groups by examining the receipt of social benefits and length of benefit spells. Furthermore, we analyse the duration of unemployment and social assistance spells that started during the outbreak of the COVID-19 pandemic and the probabilities of receiving social assistance among different socio-economic groups during the crisis. The results of our analysis show that in 2020, the receipt of unemployment and social assistance benefits was highest among young people and particularly among women. However, extending the analysis to 2021 we found that unemployment spells were shorter among young people than among older age groups. Thus, while the youngest age groups were hardest hit by the crisis in terms of the increase in the number of recipients, they seem to have recovered from it faster than the older age groups. Our findings indicate that the Finnish social security system succeeded fairly well in mitigating the negative impacts of the crisis for vulnerable groups and those who faced job loss since small adjustments to the benefits maintained the income of these groups.
IN MEMORIAM GYULA KRISTÓ (1939 2004)
Authors: Galántai Erzsébet
Published: May 2022

obituary
Sovereignty in the Political Thought of James VI, King of Scots
Authors: Radó Bálint
Published: May 2022

Contrary to a common understanding shared by many hi storians the Scottish English ruler King James (VI) and I was not an ardent defender of absolutism. It was only in his very first work written to refute and refuse the political ideas of especialy his tutor, George Buchanan as well as the group known for c ontemparies as monarchomachi (a term coined by William Barclay) that the King of Scots represented absolutist views in the Bodinian sense of the word. One should not neglect the fact that in order to be an absolutist political theoretician one must claim that the monarch is the exclusive maker of all the laws in his or her realm. This was maintained by James in The Trew Law of Free Monarchies but in none of his other works and speeches did he express himself in this vein. This holds as much true of th e Basilikon Doron as his parliamentary speeches in London or his polemical writings against the Neo Thomist Jesuits. Neverthless, he remained within the tradition of the divine right of kings throughout his life. My contribution to this volume observes The Trew Law and proves that absolutism and divine right were in fact combined by the royal author in the above mentioned treatise.
Some Remarks on “Proprietary Dynasticism and the Development of the Concept of State in 17 th Century Russia
Authors: Sashalmi Endre
Published: May 2022

H. H. Rowen termed “proprietary dynasticism” the early modern view that “public power was dynastic property”. Rowen’s work warns us not to read undue modernity into 17 th century Western monarchies, but at the same time challenges seriously R . Pipes’ contention that the patrimonial (concept of) state is a salient characteristic distinguishing Muscovite Russia from the West. I am convinced that the inclusion of “proprietary dynasticism” into historical analysis as an aspect of its own right wil l result in a better understanding of not only Western monarchies (as Rowen asserted) but also of Muscovite (and even Imperial) Russia. It should be viewed as a feature common to all monarchies. Then, not “proprietary dynasticism” itself, but its strength and endurance will be the distinguishing Russian characteristic. The strength of this view notwithstanding, important changes could and, indeed, did occur in the meaning of gosudarstvo in the 17 th century. And contrary to Pipes’ assertion, gosudarstvo coul d be distinguished from the person of the ruler even before the mid seventeenth century, i.e. before the westernization of Russian ideology.
UPPSALA AND SPALATO
Authors: Kondor Márta
Published: May 2022

Scholarship frequently applies the terms centre and periphery to different parts of Western Christendom, but there is no consensus on exactly which lands can be characterized by these terms. This paper aims at appr oaching the centre periphery problem in Western Christendom through two case studies: the archbishoprics of Uppsala and Spalato, both lying on the rim of the Latin West, were chosen as the objects of the analysis. On the basis of papal letters from the tim e of Pope Alexander III (1159 1181) the intensity and nature of contacts between the Holy See and these “faraway places” were studied. The main question addressed was what perceptions the Roman Curia had of these territories in the second half of the twelf th century.