bluuebunny/crossref_metadata_2025 huggingface dataset:
Water extract of cacumen platycladi promotes hair growth through the Akt/GSK3β/β-catenin signaling pathway
Authors: Fu Hangjie , Li Wenxia , Weng Zhiwei , Huang Zhiguang , Liu Jinyuan , Mao Qingqing , Ding Bin
Published: February 2023

Cacumen Platycladi (CP) consists of the dried needles of Platycladus orientalis L.) Franco. It was clinically demonstrated that it effectively regenerates hair, but the underlying mechanism remains unknown. Thus, we employed shaved mice to verify the hair growth-promoting capability of the water extract of Cacumen Platycladi (WECP). The morphological and histological analyses revealed that WECP application could significantly promote hair growth and hair follicles (HFs) construction, in comparison to that of control group. Additionally, the skin thickness and hair bulb diameter were significantly increased by the application of WECP in a dose-dependent manner. Besides, the high dose of WECP also showed an effect similar to that of finasteride. In an in vitro assay, WECP stimulated dermal papilla cells (DPCs) proliferation and migration. Moreover, the upregulation of cyclins (cyclin D1, cyclin-dependent kinase 2 (CDK2), and cyclin-dependent kinase 4 (CDK4)) and downregulation of P21 in WECP-treated cell assays have been evaluated. We identified the ingredients of WECP using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) and endeavored to predict their relevant molecular mechanisms by network analysis. We found that the Akt (serine/threonine protein kinase) signaling pathway might be a crucial target of WECP. It has been demonstrated that WECP treatment activated the phosphorylation of Akt and glycogen synthase kinase-3-beta (GSK3β), promoted β-Catenin and Wnt10b accumulation, and upregulated the expression of lymphoid enhancer-binding factor 1 (LEF1), vascular endothelial growth factor (VEGF), and insulin-like growth factor 1 (IGF1). We also found that WECP significantly altered the expression levels of apoptosis-related genes in mouse dorsal skin. The enhancement capability of WECP on DPCs proliferation and migration could be abrogated by the Akt-specific inhibitor MK-2206 2HCl. These results suggested that WECP might promote hair growth by modulating DPCs proliferation and migration through the regulation of the Akt/GSK3β/β-Catenin signaling pathway.
Periodic band formation of Fe(OH)3 precipitate through reaction–diffusion–reaction processes
Authors: Hayashi Hisashi
Published: February 2023

This paper reports a new class of periodic banding of Fe(OH)3 precipitate through reaction–diffusion–reaction (RDR) processes in agarose gel sandwiched between two metal rods (Ti and Fe) with cyclic alternating voltages. In the RDR processes, electrochemical reactions at metal rods to generate reactant ions, diffusion of the ions influenced by the electric field in the gel, and reactions of the ions to form precipitates were coupled to generate periodic bands of Fe(OH)3 precipitates at the cathode side. The banding morphologies, spatial Fe distribution, and microscopic morphologies of the precipitates were investigated by visual inspection, Fe Kα intensity distribution measurements, and scanning electron microscopy observations. The periodic banding strongly depended on the applied voltages, the periods for voltage alternation, the cycle number (NC), and the length of the gel column. Periodic bands resembling Liesegang bands were most clearly observed with high reproducibility for 50 mm gel columns under the applied cyclic alternating voltages of 3 and 1 V for 1 and 4 h, respectively. The number of the periodic bands formed in this system was generally given by NC—NC1 + 1, where NC1 is the cycle number where the first band emerges. These periodic bands contained significant amounts of Fe atoms that were almost uniformly distributed in the agarose gel, strongly supporting the formation of gelatinous Fe(OH)3 precipitates in the bands.
The mechanism of magnetic flux rope rotation during solar eruption
Authors: Zhou Zhenjun , Jiang Chaowei , Yu Xiaoyu , Wang Yuming , Hao Yongqiang , Cui Jun
Published: February 2023

Solar eruptions often show the rotation of filaments, which is a manifestation of the rotation of erupting magnetic flux rope (MFR). Such a rotation of MFR can be induced by either the torque exerted by a background shear-field component (which is an external cause) or the relaxation of the magnetic twist of the MFR (an internal cause). For a given chirality of the erupting field, both the external and internal drivers cause the same rotation direction. Therefore, it remains elusive from direct observations which mechanism yields the dominant contribution to the rotation. In this paper, we exploit a full MHD simulation of solar eruption by tether-cutting magnetic reconnection to study the mechanism of MFR rotation. In the simulation, the MFR’s height–rotation profile suggests that the force by the external shear-field component is a dominant contributor to the rotation. Furthermore, the torque analysis confirms that it is also the only factor in driving the counterclockwise rotation. On the contrary, the Lorentz torque inside the MFR makes a negative effect on this counterclockwise rotation.
Role of the renin–angiotensin system in the pathophysiology of coronary heart disease and heart failure: Diagnostic biomarkers and therapy with drugs and natural products
Authors: Mehta Jinit K. , Kaur Ginpreet , Buttar Harpal S. , Bagabir Hala Abubaker , Bagabir Rania Abubaker , Bagabir Sali Abubaker , Haque Shafiul , Tuli Hardeep S. , Telessy Istvan G.
Published: February 2023

The renin–angiotensin system (RAS) plays a pivotal role in blood pressure regulation. In some cases, this steering mechanism is affected by various deleterious factors (mainly via the overactivation of the RAS) causing cardiovascular damage, including coronary heart disease (CHD) that can ultimately lead to chronic heart failure (CHF). This not only causes cardiovascular disability and absenteeism from work but also imposes significant healthcare costs globally. The incidence of cardiovascular diseases has escalated exponentially over the years with the major outcome in the form of CHD, stroke, and CHF. The involvement of the RAS in various diseases has been extensively researched with significant limelight on CHD. The RAS may trigger a cascade of events that lead to atherosclerotic mayhem, which causes CHD and related aggravation by damaging the endothelial lining of blood vessels via various inflammatory and oxidative stress pathways. Although there are various diagnostic tests and treatments available in the market, there is a constant need for the development of procedures and therapeutic strategies that increase patient compliance and reduce the associated side effects. This review highlights the advances in the diagnostic and treatment domains for CHD, which would help in subjugating the side effects caused by conventional therapy.
Spectral characterization and severity assessment of rice blast disease using univariate and multivariate models
Authors: Mandal Nandita , Adak Sujan , Das Deb K. , Sahoo Rabi N. , Mukherjee Joydeep , Kumar Andy , Chinnusamy Viswanathan , Das Bappa , Mukhopadhyay Arkadeb , Rajashekara Hosahatti , Gakhar Shalini
Published: February 2023

Rice is the staple food of more than half of the population of the world and India as well. One of the major constraints in rice production is frequent occurrence of pests and diseases and one of them is rice blast which often causes yield loss varying from 10 to 30%. Conventional approaches for disease assessment are time-consuming, expensive, and not real-time; alternately, sensor-based approach is rapid, non-invasive and can be scaled up in large areas with minimum time and effort.  In the present study, hyperspectral remote sensing for the characterization and severity assessment of rice blast disease was exploited. Field experiments were conducted with 20 genotypes of rice having sensitive and resistant cultivars grown under upland and lowland conditions at Almora, Uttarakhand, India. The severity of the rice blast was graded from 0 to 9 in accordance to International Rice Research Institute (IRRI).  Spectral observations in field were taken using a hand-held portable spectroradiometer in range of 350-2500 nm followed by spectral discrimination of different disease severity levels using Jeffires–Matusita (J-M) distance. Then, evaluation of 26 existing spectral indices (r≥0.8) was done corresponding to blast severity levels and linear regression prediction models were also developed. Further, the proposed ratio blast index (RBI) and normalized difference blast index (NDBI) were developed using all possible combinations of their correlations with severity level followed by their quantification to identify the best indices. Thereafter, multivariate models like support vector machine regression (SVM), partial least squares (PLS), random forest (RF), and multivariate adaptive regression spline (MARS) were also used to estimate blast severity. Jeffires–Matusita distance was separating almost all severity levels having values >1.92 except levels 4 and 5. The 26 prediction models were effective at predicting blast severity with R2 values from 0.48 to 0.85. The best developed spectral indices for rice blast were RBI (R1148, R1301) and NDBI (R1148, R1301) with R2 of 0.85 and 0.86, respectively. Among multivariate models, SVM was the best model with calibration R2=0.99; validation R2=0.94, RMSE=0.7, and RPD=4.10. The methodology developed paves way for early detection and large-scale monitoring and mapping using satellite remote sensors at farmers’ fields for developing better disease management options.
Transcriptional profiling analysis providing insights into desiccation tolerance mechanisms of the desert moss Syntrichia caninervis
Authors: Yang Ruirui , Li Xiaoshuang , Yang Qilin , Zhao Mingqi , Bai Wenwan , Liang Yuqing , Liu Xiujin , Gao Bei , Zhang Daoyuan
Published: February 2023

Syntrichia caninervis is a desiccation tolerant moss and is the dominant bryophyte found in biological soil crusts in the Gurbantunggut desert. In this study, we assessed the transcriptome profiles of S. caninervis gametophytes during the dehydration-rehydration (D-R) process (across 9 time points) using Illumina sequencing. In total, 22489 transcripts were identified, including 5337 novel transcripts, that mapped to the reference genome. A total of 12548 transcripts exhibited significant alterations in the D-R samples compared with the control samples. The differentially expressed transcripts (DETs) possessed several enriched Gene Ontology terms, such as “water stress response”, “oxidation-reduction process”, “membrane metabolism”, “photosynthesis”, and “transcription factor activity”. Moreover, during early dehydration stress, the DETs were significantly enriched in stress-related pathways from the Kyoto Encyclopedia of Genes and Genomes, such as “phenylpropanoid biosynthesis”, “alpha-linolenic acid metabolism”, and “fructose and mannose metabolism”. Photosynthesis-related transcripts (e.g., ScPsa H, ScRubisco, and ScLhcb1) were inhibited during the dehydration treatment and significantly accumulated during the late rehydration period. Most transcripts from the late embryogenesis abundant proteins (LEA) and early light-inducible protein (ELIP) families strongly accumulated at the late dehydration stage. These pathways were positively correlated with the content changes of absolute water content and Fv/Fm values, alongside peroxidase and superoxide dismutase activities. Seven transcription factor families, including AP2-ERF, bHLH, G2-like, MYB, NAC, WRKY, and bZIP, were enriched in DETs during D-R treatment. This study is the first transcriptome analysis using the S. caninervis genome for gene annotation and multigroup D-R treatment points. Our results demonstrated the detailed dynamic changes in the transcriptome of S. caninervis during the D-R process. These results also improve understanding of desiccation tolerant plants’ adaptations to desiccation stress at the transcription level and provide promising gene resources for transgenic crop breeding.
Physical mapping of a new powdery mildew resistance locus from Thinopyrum ponticum chromosome 4AgS
Authors: Yang Guotang , Deng Pingchuan , Ji Wanquan , Fu Shulan , Li Hongwei , Li Bin , Li Zhensheng , Zheng Qi
Published: February 2023

Thinopyrum ponticum (Podp.) Barkworth and D.R. Dewey is a decaploid species that has served as an important genetic resource for improving wheat for the better part of a century. The wheat–Th. ponticum 4Ag (4D) disomic substitution line Blue 58, which was obtained following the distant hybridization between Th. ponticum and common wheat, has been stably resistant to powdery mildew under field conditions for more than 40 years. The transfer of 4Ag into the susceptible wheat cultivar Xiaoyan 81 resulted in powdery mildew resistance, indicating the alien chromosome includes the resistance locus. Irradiated Blue 58 pollen were used for the pollination of the recurrent parent Xiaoyan 81, which led to the development of four stable wheat–Th. ponticum 4Ag translocation lines with diverse alien chromosomal segments. The assessment of powdery mildew resistance showed that translocation line L1 was susceptible, but the other three translocation lines (WTT139, WTT146, and WTT323) were highly resistant. The alignment of 81 specific-locus amplified fragments to the Th. elongatum genome revealed that 4Ag originated from a group 4 chromosome. The corresponding physical positions of every 4Ag-derived fragment were determined according to a cytogenetic analysis, the amplification of specific markers, and a sequence alignment. Considering the results of the evaluation of disease resistance, the Pm locus was mapped to the 3.79–97.12 Mb region of the short arm of chromosome 4Ag. Because of its durability, this newly identified Pm locus from a group 4 chromosome of Th. ponticum may be important for breeding wheat varieties with broad-spectrum disease resistance.
Genetic mapping of QTLs controlling brown seed coat traits by genome resequencing in sesame (Sesamum indicum L.)
Authors: Wang Han , Cui Chengqi , Liu Yanyang , Zheng Yongzhan , Zhao Yiqing , Chen Xiaoqin , Wang Xueqi , Jing Bing , Mei Hongxian , Wang Zhonghua
Published: February 2023

Introduction

Sesame seeds have become an irreplaceable source of edible oils and food products with rich nutrients and a unique flavor, and their metabolite contents and physiological functions vary widely across different seed coat colors. Although the quantitative trait loci (QTLs) for genetic variation in seed coat color have been extensively investigated, the identification of unique genetic loci for intermediate colors such as brown has not been reported due to their complexity.

Methods

Here, we crossed the white sesame ‘Yuzhi No. 8’ (YZ8) and the brown sesame ‘Yanzhou Erhongpi’ (YZEHP) to construct a recombinant inbred line (RIL) population with consecutive self-fertilization for ten generations.

Results

The selfed F1 seeds were brown which was controlled by a dominant gene. Based on the genotyping by whole-genome resequencing of the RILs, a major-effect QTL for brown coat color was identified through both bulk segregant analysis (BSA) and genetic linkage mapping in sesame, which was located within a 1.19 Mb interval on chromosome 6 (qBSCchr6). Moreover, we found that the YZEHP seed coat initially became pigmented at 20 days post-anthesis (DPA) and was substantially colored at 30 DPA. We screened 13 possible candidate genes based on the effects of genetic variants on protein coding and predicted gene functions. Furthermore, qRT‒PCR was used to verify the expression patterns of these genes in different post-anthesis developmental periods. We noted that in comparison to YZ8 seeds, YZEHP seeds had expression of SIN_1023239 that was significantly up-regulated 2.5-, 9.41-, 6.0-, and 5.9-fold at 15, 20, 25, and 30 DPA, respectively, which was consistent with the pattern of brown seed coat pigment accumulation.

Discussion

This study identified the first major-effect QTL for the control of the brown seed coat trait in sesame. This finding lays the foundation for further fine mapping and cloning as well as investigating the regulatory mechanism of seed coat color in sesame.
Effects of arbuscular mycorrhizal fungus inoculation on the growth and nitrogen metabolism of Catalpa bungei C.A.Mey. under different nitrogen levels
Authors: Chen Wei , Mou Xueli , Meng Panpan , Chen Juan , Tang Xiaan , Meng Guihua , Xin Kexu , Zhang Yi , Wang Chunyan
Published: February 2023

Evidence suggests that arbuscular mycorrhizal fungi (AMF) may promote the growth of woody plants. However, the effects of AMF on nitrogen (N) metabolism in plants, especially trees, and its regulatory mechanism are rarely reported. Here, the effects of AMF inoculation on the growth and N nutrition status of Catalpa bungei under different N levels were reported. Three N levels (low, medium, high) and two mycorrhizal inoculation treatments (inoculation with Rhizophagus intraradices or not) were used with factorial design. The results showed that medium N could significantly improve the physiological metabolism and growth of C. bungei seedlings. However, when N was excessive, growth was significantly inhibited whether inoculated AMF or not. Compared with non-inoculated treatments, AMF inoculation could promote the absorption of N and P, improve photosynthesis under low to medium N levels, thus promoting the growth of seedlings. AMF changed the biomass allocation in seedlings by reducing the stem mass ratio and root/shoot ratio, and increasing the leaf mass ratio. At medium N levels, compared with non-inoculated treatment, AMF inoculation could significantly promote root growth by changing root hormone levels and improving root architecture and root activity. Under N addition, AMF inoculation could improve the absorption and assimilation of N by regulating the expression of key enzyme genes of N metabolism and nitrate transporter genes (NRT2.4, NRT2.5, NRT2.7) in roots, and enhancing the activities of the key enzyme of N metabolism. This study may provide a reference for the application of AMF in the cultivation and afforestation technology of C. bungei in Northwest China.
Two different strategies of Diversispora spurca-inoculated walnut seedlings to improve leaf P acquisition at low and moderate P levels
Authors: Zou Ying-Ning , Xu Yong-Jie , Liu Rui-Cheng , Huang Guang-Ming , Kuča Kamil , Srivastava Anoop Kumar , Hashem Abeer , Abd_Allah Elsayed Fathi , Wu Qiang-Sheng
Published: February 2023

Walnut (Juglans regia) is an important nut tree species in the world, whereas walnut trees often face inadequate phosphorus (P) levels of soil, negatively limiting its growth and yield. Arbuscular mycorrhizal fungi (AMF) can colonize walnut roots, but whether and how AMF promotes walnut growth, physiological activities, and P acquisition is unclear. The present study aimed to evaluate the effects of Diversispora spurca on plant growth, chlorophyll component concentrations, leaf gas exchange, sugar and P concentrations, and expression of purple acid phosphatase (PAP) and phosphate transporter (PT) genes in leaves of J. regia var. Liaohe 1 seedling under moderate (100 μmol/L P) and low P (1 μmol/L P) levels conditions. Three months after inoculation, the root mycorrhizal colonization rate and soil hyphal length were 45.6−53.2% and 18.7−39.9 cm/g soil, respectively, and low P treatment significantly increased both root mycorrhizal colonization rate and soil hyphal length. Low P levels inhibited plant growth (height, stem diameter, and total biomass) and leaf gas exchange (photosynthetic rate, transpiration rate and stomatal conductance), while AMF colonization significantly increased these variables at moderate and low P levels. Low P treatment limited the level of chlorophyll a, but AMF colonization did not significantly affect the level of chlorophyll components, independent on soil P levels. AMF colonization also increased leaf glucose at appropriate P levels and leaf fructose at low P levels than non-AMF treatment. AMF colonization significantly increased leaf P concentration by 21.0−26.2% than non-AMF colonization at low and moderate P levels. Low P treatment reduced the expression of leaf JrPAP10, JrPAP12, and JrPT3;2 in the inoculated plants, whereas AMF colonization up-regulated the expression of leaf JrPAP10, JrPAP12, and JrPT3;2 at moderate P levels, although AMF did not significantly alter the expression of JrPAPs and JrPTs at low P levels. It is concluded that AMF improved plant growth, leaf gas exchange, and P acquisition of walnut seedlings at different P levels, where mycorrhizal promotion of P acquisition was dominated by direct mycorrhizal involvement in P uptake at low P levels, while up-regulation of host PAPs and PTs expressions at moderate P levels.
Neural correlates of emotional valence for faces and words
Authors: Ballotta Daniela , Maramotti Riccardo , Borelli Eleonora , Lui Fausta , Pagnoni Giuseppe
Published: February 2023

Stimuli with negative emotional valence are especially apt to influence perception and action because of their crucial role in survival, a property that may not be precisely mirrored by positive emotional stimuli of equal intensity. The aim of this study was to identify the neural circuits differentially coding for positive and negative valence in the implicit processing of facial expressions and words, which are among the main ways human beings use to express emotions. Thirty-six healthy subjects took part in an event-related fMRI experiment. We used an implicit emotional processing task with the visual presentation of negative, positive, and neutral faces and words, as primary stimuli. Dynamic Causal Modeling (DCM) of the fMRI data was used to test effective brain connectivity within two different anatomo-functional models, for the processing of words and faces, respectively. In our models, the only areas showing a significant differential response to negative and positive valence across both face and word stimuli were early visual cortices, with faces eliciting stronger activations. For faces, DCM revealed that this effect was mediated by a facilitation of activity in the amygdala by positive faces and in the fusiform face area by negative faces; for words, the effect was mainly imputable to a facilitation of activity in the primary visual cortex by positive words. These findings support a role of early sensory cortices in discriminating the emotional valence of both faces and words, where the effect may be mediated chiefly by the subcortical/limbic visual route for faces, and rely more on the direct thalamic pathway to primary visual cortex for words.
The moderating effect of perceived organizational support: The impact of psychological capital and bidirectional work-family nexuses on psychological wellbeing in tourism
Authors: Bai Na , Yan Zhen , Othman Rosly
Published: February 2023

The novel coronavirus (COVID-19) has inflicted unprecedented damage on the tourism industry. However, the psychological health fallout of COVID-19 on tour guides has not received empirical attention yet. Therefore, the present study aims to examine how psychological capital (PsyCap) improve tour guides’ psychological wellbeing (PWB), the mediating effects of work-family conflict (WFC), family-work conflict (FWC), work-family facilitation (WFF) and family-work facilitation (FWF), and the moderating effect of perceived organizational support (POS). For this quantitative research, the data were collected from 276 tour guides in China. The results indicate that PsyCap significantly mitigates two directions of work-family conflict and intensifies two directions of work-family facilitation in order to promote tour guides’ PWB. Furthermore, POS moderates the direct effects of two directions of conflict and facilitation on PWB and also moderates the indirect effects of PsyCap on the aforesaid outcome via two directions of conflict and facilitation. Theoretical and practical implications, limitations and future research directions are provided.
On the intercultural sensitivity of university students in multicultural regions: A case study in Macao
Authors: Chen Hong , Hu Bo
Published: February 2023

Intercultural sensitivity has been regarded as a very important ability necessary for living in multicultural countries and regions. In this research, the quantitative method was used to explore the intercultural sensitivity of university students in Macao, a typical multicultural region in China. By adopting the Intercultural Sensitivity Scale developed by Chen and Starosta and a sociodemographic questionnaire designed by the authors, this study investigated the intercultural sensitivity level of university students in Macao, and explored whether there were any significant differences in student groups in terms of gender, grade, program (language of instruction adopted in a major), courses related to intercultural communication, overseas experience, and foreign language proficiency. The findings of the study on a sample of 375 participants showed that university students in Macao had a relatively high intercultural sensitivity level. There were significant differences in different student groups in terms of gender, grade, courses related to intercultural communication, and foreign language proficiency. This study has implications for both educational policymakers and educators and can ultimately help university students in a multicultural environment improve their intercultural sensitivity and sustainable development.
Gender composition of pairs influences joint action effect
Authors: Fabbri Marco , Martoni Monica , Beracci Alessia , Tonetti Lorenzo , Natale Vincenzo
Published: February 2023

Research on joint action has demonstrated that individuals are sensitive to a coactor’s attentional relation to jointly attend stimuli. It has also been suggested that some features are necessary to resolve the discrimination problem (i.e., self-own and other-own actions). In the present study, we aimed to test whether the gender composition of interacting pairs modulated the joint action effect. Same- (female-female or male-male) and mixed- (female-male) gender pairs performed a joint version of flanker tasks in Experiment 1 (90 participants, 50% males), while in Experiment 2 (154 participants, 50% males) Navon tasks were performed. In Experiment 1, a higher joint flanker effect in same-gender pairs than in mixed-gender pairs, and this joint effect was similar to the classical flanker effect reported by males and females in a classical procedure of the task (70 participants, 50% males). In Experiment 2, the same-gender pairs reported a joint Navon effect, which was reversed in mixed-gender pairs. In conclusion, our findings support how the gender composition of interacting pairs plays a role in joint attentional tasks.
Men’s and women’s egocentric and allocentric knowledge: The involvement of mental rotation ability and spatial beliefs
Authors: Miola Laura , Muffato Veronica , Pazzaglia Francesca , Meneghetti Chiara
Published: February 2023

Individual factors can play a relevant role in explaining gender differences in environmental learning in terms of visuospatial abilities and beliefs about spatial abilities, such as stereotypes and growth mindset about navigation ability. In this study, we aim to investigate how mental rotation ability and spatial beliefs interact in the acquisition of egocentric and allocentric spatial knowledge. A sample of 244 participants (140 women) completed individual difference measures, including a mental rotation test (MRT) and questionnaires on gender stereotypes and growth mindsets about navigation ability. Participants then learned a specific route in a virtual environment and performed an egocentric pointing task and an allocentric pointing task. Men performed better in mental rotation and egocentric pointing tasks. Moreover, mental rotation ability predicted both egocentric and allocentric pointing performance; growth mindset predicted allocentric pointing. In general, these results suggest that, despite gender differences in some spatial measures, cognitive abilities and beliefs contribute to supporting environmental knowledge in both men and women.
AI avatar tells you what happened: The first test of using AI-operated children in simulated interviews to train investigative interviewers
Authors: Haginoya Shumpei , Ibe Tatsuro , Yamamoto Shota , Yoshimoto Naruyo , Mizushi Hazuki , Santtila Pekka
Published: February 2023

Previous research has shown that simulated child sexual abuse (CSA) interview training using avatars paired with feedback and modeling improves interview quality. However, to make this approach scalable, the classification of interviewer questions needs to be automated. We tested an automated question classification system for these avatar interviews while also providing automated interventions (feedback and modeling) to improve interview quality. Forty-two professionals conducted two simulated CSA interviews online and were randomly provided with no intervention, feedback, or modeling after the first interview. Feedback consisted of the outcome of the alleged case and comments on the quality of the interviewer’s questions. Modeling consisted of learning points and videos illustrating good and bad questioning methods. The total percentage of agreement in question coding between human operators and the automated classification was 72% for the main categories (recommended vs. not recommended) and 52% when 11 subcategories were considered. The intervention groups improved from first to second interview while this was not the case in the no intervention group (intervention x time: p = 0.007, ηp2 = 0.28). Automated question classification worked well for classifying the interviewers’ questions allowing interventions to improve interview quality.
Prevalence and factors of discordance attitudes toward advance care planning between older patients and their family members in the primary medical and healthcare institution
Authors: Ye Ling , Jin Genhong , Chen Min , Xie Xingyuan , Shen Shanshan , Qiao Song
Published: February 2023

Background

This study aimed at investigating the prevalence and factors of the discordant attitudes toward advance care planning (ACP) among older patients and their family members toward patients' engagement in ACP in the primary medical and healthcare institution.

Methods

In a cross-sectional study, a total of 117 older patients and 117 family members from Jinhua Fifth Hospital in China were enrolled. The questionnaire included sociodemographic characteristics, functional capacity assessment, and attitudes toward patients' engagement in ACP. Functional capacity assessment scales included the Modified Barthel Index (MBI), the Short-Form Mini-Nutritional Assessment (MNA-SF), the 15-item Geriatric Depression Scale (GDS-15), the Mini-Mental State Examination (MMSE), the Clinical Frailty Scale (CFS), and the SARC-F questionnaire.

Results

The discordance attitudes toward patients' engagement in ACP between patients and family members accounted for 41(35.0%). In the multivariate logistic analysis, factors associated with higher odds of discordance attitudes toward patients' engagement in ACP included greater age differences between patients and family members (OR = 1.043, 95% CI: 1.007–1.081), lower educational level for family members (OR = 3.373, 95% CI: 1.239–9.181), the patient's higher GDS-15 score (OR = 1.437, 95% CI: 1.185–1.742), and patient's higher MNA-SF score (OR = 1.754, 95% CI: 1.316–2.338).

Conclusion

Older patients and their family members had little ACP knowledge, and factors that influence discordance attitudes toward patients' engagement in ACP included the age gaps between patients and family members, family members' educational level, patients' depressive symptoms, and patients' nutritional status.
Development and validation of a Systemic Sclerosis Health Literacy Scale
Authors: Zhuang Meng , Li Cheng-Cheng , Chen Shan-Yu , Tu Xin-Hua , Liu Lian , Chen Xi-Lai , Xu Cheng-Wei , Wang Jing
Published: February 2023

Background and aim

Health literacy levels are strongly associated with clinical outcomes and quality of life in patients with chronic diseases, and patients with limited health literacy often require more medical care and achieve poorer clinical outcomes. Among the large number of studies on health literacy, few studies have focused on the health literacy of people with systemic sclerosis (SSc), and there is no specific tool to measure health literacy in this group. Therefore, this study plans to develop a health literacy scale for patients with SSc.

Methods

This study included 428 SSc patients from the outpatient and inpatient departments of the Department of Rheumatology and Immunology, the first affiliated Hospital of Anhui Medical University and the first affiliated Hospital of University of Science and Technology of China. The formulation of the scale was completed by forming the concept of health literacy of SSc patients, establishing the item pool, screening items, and evaluating reliability and validity. Classical measurement theory was used to screen items, factor analysis was used to explore the construct validity of the scale, and Cronbach's alpha coefficient was used to assess the internal consistency.

Results

Our study population was predominantly middle-aged women, with a male to female ratio of 1:5.7 and a mean age of 51.57 ± 10.99. A SSc Health Literacy scale with 6 dimensions and 30 items was developed. The six dimensions are clinic ability, judgment/evaluation information ability, access to information ability, social support, treatment compliance and application information ability. The Cronbach's alpha coefficient of the scale is 0.960, retest reliability is 0.898, split-half reliability is 0.953, content validity is 0.983, which has good reliability and validity.

Conclusion

The Systemic Sclerosis Health Literacy Scale may become a valid tool to evaluate the health literacy level of patients with SSc.
A multilevel analysis of factors associated with vitamin A supplementation among children aged 6–35 months in Ethiopia
Authors: Amare Tsegaw , Sime Tseganesh , Legese Gebrehiwot Lema , Ferede Menberesibhat Getie , Alemu Melaku Birhanu
Published: February 2023

Background

Vitamin A deficiency is among the leading preventable causes of childhood morbidity and mortality that might be attributable to the low uptake of vitamin A supplementation (VAS). Factors contributing to its low utilization are not researched at the national level and with the appropriate model. Therefore, this study aimed at identifying the magnitude and the individual- and community-level factors associated with vitamin A supplementation among children aged 6–35 months in Ethiopia.

Methods

We have used the Ethiopian mini demographic and health survey data, which was conducted from 21 March to 28 June 2019. A weighted sum of 2,362 mothers having children aged 6–35 was extracted. Considering the hierarchical nature of the data, we fitted the multilevel multivariable logistic regression model. Adjusted odds ratio (AOR) with a 95% confidence interval (CI) was reported and variables with a p-value of < 0.05 were declared to be significantly associated factors.

Results

In this study, 43.4% (95% CI: 41.4–45.4%) of children have taken the VAS. Moreover, the 12–23 age of the child (AOR = 2.64; 95% CI: 1.88–3.72), 30–34 age of the mother (AOR = 3.34; 95% CI: 1.21–9.20), middle household wealth status (AOR = 1.75; 95% CI: 1.06–2.90), and four and above antenatal care (AOR = 2.90; 95% CI: 1.90–4.43) are the individual-level factors associated with VAS whereas being from Amhara (AOR = 2.20; 95% CI: 1.29–3.76) and Tigray (AOR = 2.16; 95% CI: 1.17–3.98) regions is a community-level factor significantly associated with the uptake of VAS.

Conclusion

Overall, a low proportion of children have taken the VAS in Ethiopia. The higher age of the child and mother, full antenatal care, and improved wealth status positively influence VAS. Moreover, a child from the Tigray or Amhara regions was more likely to get VAS. Therefore, an intervention has to be designed to address the VAS uptake among young mothers, and working to improve the wealth status of the household would be helpful. Moreover, the advocacy of antenatal care and minimizing the regional disparity through encouraging the uptake in the rest of the regions would help increase the national-level uptake of VAS.
Time trends in mental health indicators in Germany's adult population before and during the COVID-19 pandemic
Authors: Mauz Elvira , Walther Lena , Junker Stephan , Kersjes Christina , Damerow Stefan , Eicher Sophie , Hölling Heike , Müters Stephan , Peitz Diana , Schnitzer Susanne , Thom Julia
Published: February 2023

Background

Times of crisis such as the COVID-19 pandemic are expected to compromise mental health. Despite a large number of studies, evidence on the development of mental health in general populations during the pandemic is inconclusive. One reason may be that representative data spanning the whole pandemic and allowing for comparisons to pre-pandemic data are scarce.

Methods

We analyzed representative data from telephone surveys of Germany's adults. Three mental health indicators were observed in ~1,000 and later up to 3,000 randomly sampled participants monthly until June 2022: symptoms of depression (observed since April 2019, PHQ-2), symptoms of anxiety (GAD-2), and self-rated mental health (latter two observed since March 2021). We produced time series graphs including estimated three-month moving means and proportions of positive screens (PHQ/GAD-2 score ≥ 3) and reports of very good/excellent mental health, as well as smoothing curves. We also compared time periods between years. Analyses were stratified by sex, age, and level of education.

Results

While mean depressive symptom scores declined from the first wave of the pandemic to summer 2020, they increased from October 2020 and remained consistently elevated throughout 2021 with another increase between 2021 and 2022. Correspondingly, the proportion of positive screens first decreased from 11.1% in spring/summer 2019 to 9.3% in the same period in 2020 and then rose to 13.1% in 2021 and to 16.9% in 2022. While depressive symptoms increased in all subgroups at different times, developments among women (earlier increase), the youngest (notable increase in 2021) and eldest adults, as well as the high level of education group (both latter groups: early, continuous increases) stand out. However, the social gradient in symptom levels between education groups remained unchanged. Symptoms of anxiety also increased while self-rated mental health decreased between 2021 and 2022.

Conclusion

Elevated symptom levels and reduced self-rated mental health at the end of our observation period in June 2022 call for further continuous mental health surveillance. Mental healthcare needs of the population should be monitored closely. Findings should serve to inform policymakers and clinicians of ongoing dynamics to guide health promotion, prevention, and care.
Prevalence of overweight, obesity, and associated factors among healthcare workers in the Gaza Strip, Palestine: A cross-sectional study
Authors: Younis Joma , Jiang Hong , Fan Yahui , Wang Lina , Li Zhaofang , Jebril Majed , Ma Mei , Ma Le , Ma Mao , Hui Zhaozhao
Published: February 2023

Background

Overweight and obesity are multifactorial conditions that are prevalent in developing and developed countries. They are emerging as a significant public health concern among healthcare workers (HCWs). We aimed to estimate the prevalence of overweight and obesity and their associated factors among HCWs in the Gaza Strip.

Methods

A cross-sectional study was conducted to recruit 1,850 HCWs aged 22 years and older. Interviews were carried out to collect sociodemographic information, nutritional information, and physical activity. Anthropometric measurements [height, weight, and waist circumference] were conducted with the HCWs. The body mass index was computed to determine the prevalence of overweight and obesity. Chi-square, t-test, and one-way ANOVA were used to compare the variables, and logistic regression was used to examine the associated factors of overweight and obesity.

Results

The combined prevalence of overweight and obesity among HCWs was 65%. The result of logistic regression showed the risk of being overweight and obesity increased within the age group of 40–49 years (OR = 3.20; 95% CI: 2.37–4.32; P < 0.001). Male participants had more risk of obesity than female participants (OR = 1.77; 95% CI: 1.45–2.15). Married participants had a significantly higher risk of being overweight and obese (OR = 2.52; 95% CI: 2.05–3.28; P = 0.001). Increased monthly income was significantly associated with the risk of being overweight and obese (OR = 2.16; 95% CI: 1.22–3.83; P = 0.008). In addition, hypertension (OR = 2.49; 95% CI: 1.65–3.78; P < 0.001) and type 2 diabetes (OR = 2.42; 95% CI: 1.21–4.85; P= 0.012) were associated with overweight and obesity. Finally, a family history of NCDs was associated with overweight and obesity (OR = 1.69; 95% CI: 1.38–2.07; P < 0.001).

Conclusion

This study showed a high prevalence of overweight and obesity among HCWs. Age, monthly income, marital status, known hypertension, type 2 diabetes, and eating habits were associated with the prevalence of overweight and obesity compared to other variables that were not associated with overweight and obesity such as profession, vegetables, fruit consumption, and physical activity. Urgent action is needed to tackle overweight and obesity among HCWs.
Influence of the aerodynamic flow on the dynamic characteristics of a lightning sweeping arc
Authors: Xiao Cien , Liu Yakun
Published: February 2023

Lightning arc attachments during swept strokes are key information in the lightning protection design of fast-moving aircraft, wind turbines, rockets, etc. However, numerical modeling has not achieved success to predict the movement of lightning sweeping arcs due to the limited understanding of the complex multi-physics convolution in the arc fluid at present. This work builds a dynamic magneto-hydrodynamic (MHD) arc model based on the setup in the laboratory simulation of the lightning continuing current and couples the electric–magnetic–thermal–force processes to get insights into the lightning arc dynamics. The MHD theory and Newton’s second law of motion are also incorporated to describe the movement of arc segments in the conditions of aerodynamic flows with different intensities. Results show that, at the center region of the arc, the electromagnetic force, thermal buoyancy, and aerodynamic force are competitive, and all are determiners in predicting the arc displacement. In contrast, at the root region of the arc, the electromagnetic force dominates the arc movement with a flow speed under 10 m/s, while aerodynamic force takes the dominant role when the flow speed exceeds 50 m/s. The arc sweeping distance expands from 0.02 to 1.01 m as the aerodynamic flow increases from 5 to 200 m/s. Meanwhile, when increasing the pitch angle of the arc-connected surface, the arc root becomes more attached to the surface and the sweeping distance is predicted to get reduced. The conclusions offer references to construct a numerical model and predict the complex arc movement during lightning sweeping strokes.
Semi-analytical orbital model around an oblate body with an inclined eccentric perturber
Authors: Fu Tao , Wang Yue , Hu Weiduo
Published: February 2023

The semi-analytical model (based on the averaging technique) for long-term orbital evolution has proven to be useful in both astrophysical and astrodynamical contexts. In this secular approximation, orbits exhibit rich evolutionary behaviors under the effects of various perturbations. For example, in the hierarchical three-body systems, the Lidov-Kozai mechanism based on the quadrupole-level third-body perturbation model can produce large-amplitude oscillations of the eccentricity and inclination. In recent years, the octupole order has been found to induce dramatically new features when the perturbing body’s orbit is eccentric, including extremely high eccentricities and orbit flips between prograde and retrograde. Motivated by the striking effects of the octupole-order terms, we intend to derive a more general dynamical model by incorporating J2 of the central body and the inclined eccentric third-body perturbation to the hexadecapole order with its non-spherical gravity also included. This issue can be relevant for astrophysical and astrodynamical systems such as planets in stellar binaries, irregular satellites in planetary systems, and artificial probes about binary asteroid systems. Applications to the binary asteroid system 4951 Iwamoto and a fictitious exoplanetary system are illustrated as examples to validate our secular model. From these numerical results, we show the high accuracy of our secular model. Also, we show the important role of these high-order terms and the effects of the third-body’s inclination and eccentricity. Besides, we have found several different secular effects that could drive large eccentricities.
Latitudinal dependence of ground VLF transmitter wave power in the inner magnetosphere
Authors: Xia Zhiyang , Chen Lunjin , Gu Wenyao , Horne Richard B. , Miyoshi Yoshizumi , Kasahara Yoshiya , Kumamoto Atsushi , Tsuchiya Fuminori , Nakamura Satoko , Kitahara Masahiro , Shinohara Iku
Published: February 2023

In this study, we use approximately 3 years of observations from the Exploration of energization and Radiation in Geospace (ERG/Arase) satellite to statistically study the meridional distribution of wave power from very-low-frequency (VLF) ground transmitters in the inner magnetosphere and analyze the corresponding latitudinal dependence. The results show that the mean intensity of NWC transmitter signals decreases as the transmitter emission propagates from the southern latitude (∼—30°) region to the equator in the inner magnetosphere and then increases as the emission propagates to the northern latitude (∼30°) region again. Similar latitudinal dependence can be found from the Van Allen Probes’ observation with a narrower latitude range (∼−20° to 0°). A ray-tracing simulation of the transmitter emission propagation is performed and reproduces a meridional wave power distribution similar to the observation. Similar latitudinal dependence can also be found for NAA, NLK and NLM transmitters.
Addressing human rights abuses at mega-sporting events—A shared responsibility in theory and practice
Authors: Heerdt Daniela
Published: February 2023

Mega-sporting events (MSEs) have great potential to promote human rights and be a force for good, not only in the host country or city where the event takes place, but also beyond. At the same time, these events are regularly linked to human rights abuses and this opinion piece provides an overview of MSE-related adverse human rights impacts and discusses how the governance of these events enables these impacts to occur in the context of bidding for, preparing, and delivering these events. At the core of this discussion the paper presents a shared responsibility approach and argues that if applied in a preventative and retrospective way and including the concept of collaborative remedy, it can help address these adverse impacts. This is followed by a reflection on the feasibility of this approach, by considering to what extent current developments in the evolving sport and human rights movement are going in that direction and the paper finishes with a brief discussion on the importance of making the current changes sustainable and how research and education are key elements of this endeavour.