bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative effectiveness of a second-line biologic in patients with ulcerative colitis: vedolizumab followed by an anti-TNF versus anti-TNF followed by vedolizumab
Authors: Miller Charles , Kwok Hanson , Harrow Paul , Vega Roser , Seward Edward , Mehta Shameer , Rahman Farooq , McCartney Sara , Parisi Ioanna , Lim Samuel Hsiang , Sharma Esha , Samaan Mark A , Bancil Aaron , Kok Klaartje Bel , Shalabi Ahmed , Johnston Emma L , Katarey Dev , Taherzadeh Nina , Murray Charles , Sharip Mohammed Tauseef , Carter Martyn J , Radhakrishnan Shiva T , Peake Simon , Khakoo Imran , Wahed Mahmood , Povlsen Sebastian , Patel Mehul , DuBois Patrick , Finkel Jemima , Onnie Clive , Bloom Stuart
Published: January 2022

Background

Sequential drug treatment with biological agents in ulcerative colitis (UC) is becoming increasingly complex. There are few studies comparing head-to-head outcomes in second-line treatments. The study assesses whether using anti-tumour necrosis factor (anti-TNF)-α therapy following the α4β7 integrin blocker vedolizumab (VDZ) or VDZ after an anti-TNF has more favourable clinical outcomes in UC in a real-world outpatient setting.

Methods

Patients with UC who were exposed to first-line anti-TNF (adalimumab or infliximab) or VDZ who subsequently switched to the alternate class between May 2013 and August 2020 were identified by reviewing patient databases at 10 hospitals. Data were collected retrospectively using patient records. Baseline demographics, disease activity indices, biochemical markers, endoscopic Mayo score, colectomy rates, treatment persistence and urgent hospital utilisation composite endpoint (UHUC) rates were examined over a 52-week period.

Results

Second-line week 52 treatment persistence was higher in the VDZ group (71/81, 89%) versus the anti-TNF group (15/34, 44%; p=0.0001), as were week 52 colectomy-free survival (VDZ: 77/80, 96%, vs anti-TNF: 26/32, 81%; p=0.009), week 52 UHUC survival (VDZ: 68/84, 81%, vs anti-TNF: 20/34, 59%; p=0.002) and week 52 corticosteroid-free clinical remission (CFCR) rates (VDZ: 22/34, 65%, vs anti-TNF: 4/20, 20%; p=0.001).

Conclusion

Compared with second-line anti TNF usage, the VDZ second-line cohort had significantly higher 52-week treatment persistence, UHUC survival, higher colectomy-free survival rates and higher week 52 CFCR. These data suggest that VDZ is an effective biologic in UC as a second-line therapy after anti-TNF exposure. It highlights the effect of biological order on clinically important outcomes.
Expression of interferon-γ and its effect on cough hypersensitivity in chronic refractory cough patients
Authors: Sun Jiayang , Zhan Chen , Deng Zheng , Luo Wei , Chen Qiaoli , Jiang Mei , Zhong Nanshan , Lai Kefang
Published: January 2022

Chronic refractory cough (CRC) is characterised by cough hypersensitivity. Interferon-γ (IFN-γ) has been reported to induce calcium influx, action potentials of vagal neurons in vitro and cough response in guinea pigs. While the effect of IFN-γ in CRC patients remains unknown. Here, via flow-cytometry and inhalation cough challenge, we found CRC patients had significantly increased levels of sputum IFN-γ+CD4+T cells, IFN-γ+CD8+T cells as well as supernatant of IFN-γ. The average number of coughs in CRC patients increased as the concentration of inhaled IFN-γ went up in IFN-γ cough challenge. Two or more coughs and five or more coughs elicited by inhaled IFN-γ in CRC patients occurred in 7 of 10 and 2 of 10, respectively. Preinhaled IFN-γ (100 µg/mL) increased the capsaicin cough sensitivity in CRC patients but not healthy volunteers. Targeting IFN-γ may be a potential effective anti-tussive strategy in CRC patients.
Proteomic and lipidomics analyses of high fatty acid AhDGAT3 transgenic soybean reveals the key lipase gene associated with the lipid internal mechanism
Authors: Xu Yang , Yan Fan , Zong Yu , Li Jingwen , Gao Han , Liu Yajing , Wang Ying , Zhu Youcheng , Wang Qingyu
Published: January 2022

Vegetable oil is one of the most important components of human nutrition. Soybean (Glycine max) is an important oil crop worldwide and contains rich unsaturated fatty acids. Diacylglycerol acyltransferase (DGAT) is a key rate-limiting enzyme in the Kennedy pathway from diacylglycerol (DAG) to triacylglycerol (TAG). In this study, we conducted further research using T3 AhDGAT3 transgenic soybean. A high-performance gas chromatography flame ionization detector showed that oleic acid (18:1) content and total fatty acid content of transgenic soybean were significantly higher than those of the wild type (WT). However, linoleic acid (18:2) was much lower than that in the WT. For further mechanistic studies, 20 differentially expressed proteins (DEPs) and 119 differentially expressed metabolites (DEMs) were identified between WT (JACK) and AhDGAT3 transgenic soybean mature seeds using proteomic and lipidomics analyses. Combined proteomic and lipidomics analyses showed that the upregulation of the key DEP (lipase GDSL domain-containing protein) in lipid transport and metabolic process induced an increase in the total fatty acid and 18:1 composition, but a decrease in the 18:2 composition of fatty acids. Our study provides new insights into the deep study of molecular mechanism underlying the enhancement of fatty acids in transgenic soybeans, especially oleic acid and total fatty acid, which are enhanced by over-expression of AhDGAT3.
Angular distributions for multi-body semileptonic charmed baryon decays
Authors: Huang Fei , Zhang Qi-An
Published: January 2022

We perform an analysis of angular distributions in semileptonic decays of charmed baryons$$B_1^{(\prime )}\rightarrow B_2^{(\prime )}(\rightarrow B_3^{(\prime )}B_4^{(\prime )})\ell ^+\nu _{\ell }$$B1(′)→B2(′)(→B3(′)B4(′))ℓ+νℓ, where the$$B_1{=}(\Lambda _c^+,\Xi _c^{(0,+)})$$B1=(Λc+,Ξc(0,+))are the SU(3)-antitriplet baryons and$$B_1'{=}\Omega _c^-$$B1′=Ωc-is an SU(3) sextet. We will firstly derive analytic expressions for angular distributions using the helicity amplitude technique. Based on the lattice quantum chromodynamics (QCD) results for$$\Lambda _c^+\rightarrow \Lambda $$Λc+→Λand$$\Xi _c^0\rightarrow \Xi ^-$$Ξc0→Ξ-form factors and model calculation of the$$\Omega _c^0\rightarrow \Omega ^-$$Ωc0→Ω-transition, we predict the branching fractions:$${\mathcal {B}}(\Lambda _{c}^{+} \rightarrow \Lambda (\rightarrow p \pi ^{-}) e^{+} \nu _{e})=2.48(15)\%$$B(Λc+→Λ(→pπ-)e+νe)=2.48(15)%,$${\mathcal {B}}(\Lambda _{c}^+\rightarrow \Lambda (\rightarrow p \pi ^{-})\mu ^{+}\nu _{\mu })=2.50(14)\%$$B(Λc+→Λ(→pπ-)μ+νμ)=2.50(14)%,$${\mathcal {B}}(\Xi _{c}^0\rightarrow \Xi ^-(\rightarrow \Lambda \pi ^{-})e^{+}\nu _{e})=2.40(30)\%$$B(Ξc0→Ξ-(→Λπ-)e+νe)=2.40(30)%,$${\mathcal {B}}(\Xi _{c}^0\rightarrow \Xi ^-(\rightarrow \Lambda \pi ^{-})\mu ^{+}\nu _{\nu })=2.41(30)\%$$B(Ξc0→Ξ-(→Λπ-)μ+νν)=2.41(30)%,$${\mathcal {B}}(\Omega _{c}^0\rightarrow \Omega ^-(\rightarrow \Lambda K^{-})e^{+}\nu _{e})=\!0.362(14)\%$$B(Ωc0→Ω-(→ΛK-)e+νe)=0.362(14)%,$${\mathcal {B}}(\Omega _{c}^0\rightarrow \Omega ^-\!(\rightarrow \Lambda K^{-})\mu ^{+\!}\nu _{\nu })=0.350(14)\%$$B(Ωc0→Ω-(→ΛK-)μ+νν)=0.350(14)%. We also predict the$$q^2$$q2dependence and angular distributions of these processes, in particular the coefficients for the$$\cos n\theta _{\ell }$$cosnθℓ($$\cos n\theta _{h}$$cosnθh,$$\cos n\phi $$cosnϕ)$$(n=0, 1, 2, \ldots )$$(n=0,1,2,…)terms. This work can provide a theoretical basis for the ongoing experiments at BESIII, LHCb, and BELLE-II.
Computational analysis of novel variable displacement pumps
Authors: Nema Anurag Ashokkumar , Gandhe Nagraj R.
Published: January 2022

The centralized lubrication system is an important mechanism required in most industries where the pumps provide the lubricant. This study is aimed to design a variable displacement pump that will replace the existing pump and reduce the cost of the operations required to provide the lubrication as per the requirement. A novel design of variable displacement pump is proposed with different components providing the variable discharge. Initially, the design of the variable displacement pump is evaluated, and analytical solutions are validated numerically. Numerical simulations are performed for the forces obtained in the analytical calculations, and the design proposed is safe within the permissible limit. The novel variable displacement pump proposed will reduce the wastage of fluid.
Properties of the compressibility and transport motion in wall-bounded turbulent flows at Mach 8
Authors: Li Xin , Zhang Siyuan , Duan Junyi , Liu Xiaobo , Wu Wanghao
Published: January 2022

The compressibility effect and transport motion in highspeed turbulent boundary layer (TBL) is a fundamental problem because they dominate the average and statistical characteristics. Using the statistical methods and flow visualization technology, flat-plate TBLs at [Formula: see text] with high- and low-wall temperatures, [Formula: see text] and 1.9, are investigated based on the direct numerical simulation (DNS) datasets. Compared with previous studies, this study considers relative higher Mach number and strong cold wall temperature condition at the same time. First, the turbulent Mach number and turbulent intensity show that the compressibility effects are enhanced by the cooling process. Second, the high-order statistical moments and structure parameters confirm cold wall that causes stronger compressibility and the corresponding increased intensities of local streamwise and wall-normal transport motions. Finally, for uncovering the relationship between the compressibility effect and turbulent transport, more in-depth visualization analyses of velocity streaks are performed. It is found that ‘knot-like’ structures are generated when cooling the wall, and they lead to stronger intermittent, which results in the rapid increase of local compressibility effect and the wall-normal transport motion. Our research sheds light on providing a theoretical basis for further understanding the compressibility effects of TBL at high Mach number.
Spin alignment measurement of vector mesons produced in high energy collisions
Authors: Mohanty Bedangadas , Kundu Sourav , Singha Subhash , Singh Ranbir
Published: January 2022

This paper covers the recent experimental development on spin alignment measurements of [Formula: see text] and [Formula: see text] vector mesons in heavy-ion and [Formula: see text] collisions at RHIC and LHC energies. Measurements in [Formula: see text] collisions at LEP energies are also discussed. Spin alignment of vector mesons is studied by measuring the second diagonal element [Formula: see text] of spin density matrix. The spin density matrix element [Formula: see text] is obtained by measuring the angular distribution of vector meson decay daughter with respect to the quantization axis in vector meson rest frame. Measured [Formula: see text] values for vector mesons are found to be larger than [Formula: see text] at high momentum in [Formula: see text] collisions at LEP energies, suggesting the preferential production of vector meson with helicity zero state from the fragmentation process. The [Formula: see text] values are found to be smaller than [Formula: see text] ([Formula: see text] implies no spin alignment) for [Formula: see text] and [Formula: see text] vector mesons at low transverse momentum in Pb–Pb collisions at [Formula: see text] TeV. These observations are qualitatively consistent with the expectation from models which attribute the spin alignment effect due to polarization of quarks in the presence of large initial angular momentum in noncentral heavy-ion collisions and its subsequent hadronization by the process of recombination. No significant spin alignment effect is observed for [Formula: see text] [Formula: see text] in mid-central Pb–Pb collisions and for vector mesons in [Formula: see text] collisions. However, the preliminary results of [Formula: see text] for [Formula: see text] mesons are larger than [Formula: see text] at intermediate [Formula: see text] in Au–Au collisions at RHIC energies and can be attributed to the presence of [Formula: see text] meson field. Although there is evidence of spin alignment effect of vector mesons in heavy-ion collisions but the measured effect is surprisingly larger in context of hyperon polarization. Therefore, these results will trigger further theoretical study.
Recursive structure of the Gauß hypergeometric function and boundary/crosscap conformal block
Authors: Nakayama Yu
Published: January 2022

The Gauß hypergeometric function shows a recursive structure which resembles those found in conformal blocks. We compare it with the recursive structure of the conformal block in boundary/crosscap conformal field theories that is obtained from the representation theory. We find that the pole structure perfectly agrees but the recursive structure in the Gauß hypergeometric function is slightly “off-shell”.
Twin-field quantum key distribution over free-space optical channels in the presence of atmospheric turbulence
Authors: Huang Yuqing , Sun Zhongqi , Dou Tianqi , Wang Jipeng , Li Zhenhua , Zhou Fen , Han Yanxin , Ma Haiqiang
Published: January 2022

Future quantum communication networks envisaged on a global scale will include various networks interlinked via optical fiber and free space channels. In recent years, quantum key distribution (QKD) protocol based on optical fiber has been extensively studied. Twin-field QKD (TF-QKD) may enable 550 km QKD using standard optical fiber without quantum repeaters. However, the performance of TF-QKD in free-space channel is still unclear. In this paper, a free-space channel model is proposed with specific turbulence characterization discussed. Here, the key rate of TF-QKD under multiple scenarios considering the variation of turbulence and different link configuration is investigated. Simulation results demonstrate that the performance of free-space TF-QKD is related to link configuration and turbulence motion which is determined by surface feature, time and height. Furthermore, TF-QKD protocol is a potential scheme for the free-space quantum communication.
Detrital zircon geochronology of Late Cretaceous successions in the Ganzhou Basin, South China: evidence of a major tectonic transition
Authors: Wang Jun , Yuan Yujie , Zhang Dexian , Chang Su-Chin
Published: January 2022

Situated within the southern segment of the South China Block, the Ganzhou Basin formed owing to subduction of the palaeo-Pacific plate beneath the South China Block. Late Cretaceous successions in this basin consist of fluvial and lacustrine facies red beds hosting abundant dinosaur and dinosaur egg fossils. This study reports detrital zircon geochronological data from a crystallized tuff and four sandstones found in the Late Cretaceous Ganzhou Group of the Ganzhou Basin. Age distributions included four major age subpopulations of predominantly Triassic, Devonian–Ordovician, Neoproterozoic and Paleoproterozoic ages. These indicate source material derived from Yanshanian and Triassic granitoids as well as from Kwangsian and Jiangnan orogens. Age signatures generally resemble those recorded in the adjacent Nanxiong Basin but also include distinctive features. Provenance signatures from successive units indicate a tectonic transition from intracontinental extension at
c.
120 Ma to compression near the Cretaceous/Paleogene boundary. This tectonic transition was probably driven by continent–continent collision between the Indian and Eurasian plates, as well as by a shift in the subduction direction of the palaeo-Pacific plate beneath the Eurasian plate.
Privacy and Safety on Social Networking Sites: Autistic and Non-Autistic Teenagers’ Attitudes and Behaviors
Authors: Rocheleau Jessica N. , Chiasson Sonia
Published: January 2022

Autistic teenagers are suspected to be more vulnerable to privacy and safety threats on social networking sites (SNS) than the general population. However, there are no studies comparing these users’ privacy and safety concerns and protective strategies online with those reported by non-autistic teenagers. Furthermore, researchers have yet to identify possible explanations for autistic teenagers’ increased risk of online harms. To address these research gaps, we conducted semi-structured interviews with 12 autistic and 16 non-autistic teenagers assessing their privacy- and safety-related attitudes and behaviors on SNS, and factors affecting them. We used videos demonstrating relevant SNS scenarios as prompts to engage participants in conversation. Through our thematic analyses, we found evidence that autistic teenagers may be more averse to taking risks on SNS than non-autistic teenagers. Yet, several personal, social, and SNS design factors may make autistic teenagers more vulnerable to cyberbullying and social exclusion online. We provide recommendations for making SNS safer for autistic teenagers. Our research highlights the need for more inclusive usable privacy and security research with this population.
Hypothesis Formalization: Empirical Findings, Software Limitations, and Design Implications
Authors: Jun Eunice , Birchfield Melissa , De Moura Nicole , Heer Jeffrey , Just René
Published: January 2022

Data analysis requires translating higher level questions and hypotheses into computable statistical models. We present a mixed-methods study aimed at identifying the steps, considerations, and challenges involved in operationalizing hypotheses into statistical models, a process we refer to as
hypothesis formalization
. In a formative content analysis of 50 research papers, we find that researchers highlight decomposing a hypothesis into sub-hypotheses, selecting proxy variables, and formulating statistical models based on data collection design as key steps. In a lab study, we find that analysts fixated on implementation and shaped their analyses to fit familiar approaches, even if sub-optimal. In an analysis of software tools, we find that tools provide inconsistent, low-level abstractions that may limit the statistical models analysts use to formalize hypotheses. Based on these observations, we characterize hypothesis formalization as a dual-search process balancing conceptual and statistical considerations constrained by data and computation and discuss implications for future tools.
Vine Weevil,Otiorhynchus sulcatus(Coleoptera: Curculionidae), Management: Current State and Future Perspectives
Authors: Pope Tom W. , Roberts Joe M.
Published: January 2022

Vine weevil, also known as black vine weevil, Otiorhynchus sulcatus, has been one of the most economically important pest species of global horticultural crops for the past five decades. This period has seen many changes in crop protection practices, including wide-scale adoption of biological controls such as entomopathogenic nematodes and fungi in place of conventional synthetic insecticides. Despite the experimental efficacy of these controls, growers continue to report significant crop losses associated with vine weevil infestation. We argue that simply switching from synthetic insecticides to biological controls, rather than using these controls as part of an integrated management program, is a key factor in the continued importance of this pest. An improved understanding of vine weevil biology and ecology is at the center of the development of truly integrated pest management programs. To this end, we identify opportunities created through recent vine weevil research and highlight key knowledge gaps in which further research may contribute to improved future management approaches.
Defense in Social Insects: Diversity, Division of Labor, and Evolution
Authors: Abbot Patrick
Published: January 2022

All social insects defend their colony from predators, parasites, and pathogens. In Oster and Wilson's classic work, they posed one of the key paradoxes about defense in social insects: Given the universal necessity of defense, why then is there so much diversity in mechanisms? Ecological factors undoubtedly are important: Predation and usurpation have imposed strong selection on eusocial insects, and active defense by colonies is a ubiquitous feature of all social insects. The description of diverse insect groups with castes of sterile workers whose main duty is defense has broadened the purview of social evolution in insects, in particular with respect to caste and behavior. Defense is one of the central axes along which we can begin to organize and understand sociality in insects. With the establishment of social insect models such as the honey bee, new discoveries are emerging regarding the endocrine, neural, and gene regulatory mechanisms underlying defense in social insects. The mechanisms underlying morphological and behavioral defense traits may be shared across diverse groups, providing opportunities for identifying both conserved and novel mechanisms at work. Emerging themes highlight the context dependency of and interaction between factors that regulate defense in social insects.
Pest Biological Control: Goals Throughout My Life
Authors: Li Liying
Published: January 2022

This autobiography documents the life and accomplishments of Li Liying. Born into a poor family in China, she eventually became director of Guangdong Entomological Institute. After graduating middle school (1949), she was admitted to the Agronomy Faculty at Beijing Agricultural University but was shortly after redirected by the Chinese Government to Timiryazev Agricultural Academy, Moscow, Russia. The last year of her study at Timiryazev Agricultural Academy was a pivotal experience. She had the opportunity to conduct fieldwork on cotton pest control and became aware of the harmful practice of aerially spraying highly toxic organophosphates with workers present. She decided to dedicate herself to finding safer alternatives and became a leader in the development of mass-rearing techniques for insects beneficial to agriculture. She traveled to laboratories in several foreign countries to foster collaboration and exchange of ideas among colleagues. She is recognized for her service to entomological societies, teaching at universities, and love of entomology.
Emotion and Politics: Noncognitive Psychological Biases in Public Opinion
Authors: Webster Steven W. , Albertson Bethany
Published: January 2022

Contemporary politics is noteworthy for its emotional character. Emotions shape and, in turn, are elicited by partisan polarization, public opinion, and political attitudes. In this article, we outline recent work in the field of emotion and politics with an emphasis on the relationship between emotion and polarization, issue attitudes, information processing, and views on democratic governance. We also highlight a growing body of scholarship that examines the racial and gender differences in emotion's ability to affect political behavior. We conclude with a discussion of unaddressed questions and suggestions for future directions for scholars working in this area of growing importance.
Performance Improvement of Supercapacitor Materials with Crushed 3D Structured Graphene
Authors: Reaz Akter Hossain , Saha Shimul , Roy Chanchal Kumar , Hosen M. Mozammal , Shuvo Tanmay Sarker , Islam Md. Mominul , Firoz Shakhawat Hossain
Published: January 2022

Electrochemical capacitor devices with conventional 2D-graphene sheets (2D-rGO) often demonstrate poor performance, especially in cyclability due to the lamellar stacking and agglomeration of the electrode materials. Herein, we have proposed that crushed 3D-graphene (c-3D-rGO) can overcome the limitations. A simplistic way to prepare 3D-crushed graphene structures has been presented utilizing metal rGO core–shell (Ni@rGO) followed by acid leaching. The electrochemical performances of the prepared c-3D-rGO were evaluated as capacitor material using a three-electrode system with aqueous 0.5 M Na2SO4 solution through cyclic voltammetry and galvanostatic charge-discharge measurements. In addition, 2D-rGO was separately prepared to compare the performance with 3D-crushed graphene structures. It has been observed that the calculated specific capacitance (C
sp) value of the prepared c-3D-rGO was 335 Fg−1 at a current density of 0.15 Ag−1, which was about three times higher than that of the 2D-rGO. Furthermore, the c-3D-rGO electrode retained 100% capacitance of its initial value after 10000 cycles, demonstrating the material’s excellent electrochemical stability. Again, to show the performance in hybrid capacitors, manganese oxide (MnOx) was incorporated onto 2D-rGO and c-3D-rGO. The presence of MnOx significantly improved the capacitive performance of 2D-rGO and c-3D-rGO. The C
sp value (532 Fg−1) of the prepared 3D-rGO/MnOx was much higher than that of 2D-rGO/MnOx (284 Fg−1) at a current density of 0.15 Ag−1. The c-3D-rGO/MnOx composite materials also showed good cyclic stability. The high-performance of the c-3D-rGO could be correlated with the structural features of uneven defects and 3D-voids present in the material, which maintained a low level of aggregation. This study is expected to broaden the application of graphene for commercial use.
Defect-Pairs of Titanium and Carbon in Iron Oxide Film for Efficient Visible Light Driven Water Splitting
Authors: Choi Il Yong , Kim Donghun , Jeon Tae Hwa , Chae Byeong-Gyu , Lee Kug-Seung , Park Chan-Gyung , Choi Wonyong , Han Sang Soo , Kim Jong Kyu
Published: January 2022

Solar-powered photoelectrochemical (PEC) water splitting has been a promising candidate for producing hydrogen in a clean and renewable way. Photoelectrodes are key components in PEC cells for efficient and stable hydrogen generation because they play crucial roles in absorption of photons, the separation and transportation of photo-generated charge carriers, as well as the chemical reactions with water. A variety of metal oxides for efficient photoelectrode have been intensively explored, but it is still challenging to find desirable materials to satisfy lots of requirements for PEC water splitting.

Iron oxide (hematite, Fe2O3) has recently attracted much attention due to its earth abundance, low cost as well as desirable material properties for PEC water oxidation including narrow band gap energy of 2.0~2.2eV for visible light absorption and proper energy band alignment, etc. However, Fe2O3 has very short hole diffusion length and low carrier mobility, which causes considerable recombination of photo-generated electrons and holes. A lot of approaches such as nanostructures, heterojunction with other materials, surface modification, etc. have been reported to prevent the recombination of charge carriers and improve electrical properties of Fe2O3; however, these require complex manufacturing processes.

In the present work, we found a much simpler way to improve the electrical properties of Fe2O3 film, namely defect-pairs due to co-doping. Titanium (Ti) and carbon (C) co-doped thin Fe2O3 film (i.e. (Ti,C)-Fe2O3) has been realized via a combination of simple solution-based spin-coating and tube furnace annealing process. This film turns out to lead significantly enhanced PEC performance when used as a photoanode: an impressively high photocurrent density of more than 4.5mAcm-2 was achieved at 1.23VRHE under AM1.5G solar spectrum and 1 sun illumination. This is compared to the value of Ti-doped Fe2O3 film, which is only about 2.6mAcm-2 photocurrent density at 1.23VRHE even though the optical properties of each film are similar. The origin for such substantial enhancement was revealed using a series of experimental and computational spectroscopies. X-ray absorption spectroscopy, electrochemical impedance measurements and density-functional-theory calculations both indicate that C atoms can be more deeply and heavily doped under the existence of Ti dopants in Fe2O3 film and then the defect-pairs of Ti and C increase not only charge carrier density but also electron’s mobility. An emphasis should be placed on the fact that this achievement was not assisted by co-catalysts and complex nanostructuring methods; hence even higher performance is expected when the film is further treated with extra-cares.
Nanoporous MnO2 Nanoflakes Modified Carbon Cloth Material for Efficient Removal of Heavy Metal Ions in Water by Capacitive Deionization
Authors: Wang Ying , Blackwood Daniel J
Published: January 2022

Increasing demand for the limited resource of fresh water for the large urban populations and development of agriculture and industry draws public concern. Removal of heavy metals such as lead, cadmium, chromium and mercury is crucial in environmental improvement of water and industrial wastewater treatment. Great efforts have been made through chemical precipitation, adsorption, ion exchange, filtration and electrochemical treatment. However, a large volume of sludge residue, expensive and complex matrix materials and low efficiency are still problems that need to be improved.

Capacitive deionization (CDI) is a promising energy-efficient technology for water desalination, which is easy to handle and environmentally friendly producing no secondary contaminants through the water purifying process [1]. In order to effectively remove ions, the porous electrodes with large surface area, good chemical stability, high electronic conductivity, and hydrophility are key factors in the selection of CDI materials. Highly porous carbon materials represent the typical electrodes to store the ions through surface ion adsorption/desorption, which is generally categorized as electrochemical double layer. By contrast, pseudocapacitors that consist of conducting polymers and transition metals, store more charge through redox reactions.

Among the alternative candidates, the natural abundant and environmental benign MnO2 is of particular interest for research, due to its high theoretical specific capacitance and the ability to be use in mild aqueous electrolytes which expand its practical application [2-3]. MnO2 can be fabricated easily and its morphology can be controlled during simple hydrothermal growth processes. Direct growth on carbon cloth, which is an excellent flexible and conductive substrate, could enhance the regeneration and reuse property of MnO2 as an ideal CDI electrode.

Porous MnO2@cabon cloth composites were prepared via a facile hydrothermal method (Figure a). The BET result showed that the average pore width is 18.2 nm. To investigate the CDI property of removing the heavy metal ions, one piece of MnO2@CC and one piece of activated carbon@graphite paper were assembled as working and counter electrodes respectively. This work confirmed the potential of using MnO2@CC as a good CDI electrode material for removal of heavy metal ions from water (Figure b).

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Figure 1
Sympathetic neural responses to sleep disorders and insufficiencies
Authors: Greenlund Ian M. , Carter Jason R.
Published: January 2022

Short sleep duration and poor sleep quality are associated with cardiovascular risk, and sympathetic nervous system (SNS) dysfunction appears to be a key contributor. The present review will characterize sympathetic function across several sleep disorders and insufficiencies in humans, including sleep deprivation, insomnia, narcolepsy, and obstructive sleep apnea (OSA). We will focus on direct assessments of sympathetic activation, e.g., plasma norepinephrine and muscle sympathetic nerve activity, but include heart rate variability (HRV) when direct assessments are lacking. The review also highlights sex as a key biological variable. Experimental models of total sleep deprivation and sleep restriction are converging to support several epidemiological studies reporting an association between short sleep duration and hypertension, especially in women. A systemic increase of SNS activity via plasma norepinephrine is present with insomnia and has also been confirmed with direct, regionally specific evidence from microneurographic studies. Narcolepsy is characterized by autonomic dysfunction via both HRV and microneurographic studies but with opposing conclusions regarding SNS activation. Robust sympathoexcitation is well documented in OSA and is related to baroreflex and chemoreflex dysfunction. Treatment of OSA with continuous positive airway pressure results in sympathoinhibition. In summary, sleep disorders and insufficiencies are often characterized by sympathoexcitation and/or sympathetic/baroreflex dysfunction, with several studies suggesting women may be at heightened risk.
Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection
Authors: Dillon Gabrielle A. , Wolf S. Tony , Alexander Lacy M.
Published: January 2022

Healthy young adults who have had mild-to-moderate COVID-19 do not display alterations in nitric oxide-mediated cutaneous microvascular function. In addition, healthy young adults who have COVID-19 antibodies from the COVID-19 vaccinations do not display alterations in nitric oxide-mediated cutaneous microvascular function.
Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran
Authors: Sadeghian Zahra , Bannazadeh Baghi Hossein , Poortahmasebi Vahdat , Sadeghi Javid , Hasani Alka , Azadi Arezoo , Ahangar Oskouee Mahin
Published: January 2022

Background. Human papillomavirus (HPV) is one of the most important viral agents associated with several classes of cancers in humans. The aim of this study was to investigate HPV in esophageal cancer in the East Azerbaijan province, northwest of Iran. Methods. 140 paraffin-embedded specimens of esophageal tissues were investigated using nested-polymerase chain reaction (nested-PCR) with primer designing for the L1 region of HPV genome. According to the pathological diagnosis, the samples were divided into two groups: 70 patients with esophageal cancer EADC (n = 35) and ESCC (n = 35) as the case group and those without tumour in esophagus tissue as a control (n = 70). Results. HPV DNA was isolated from 20 (28.57%) of the 70 paraffin-embedded tissue specimens of esophagus cancer. Of these, 6 cases (17.14%) of EADC and 14 cases (40%) of ESCC were positive. In contrast, all cases of the control group were negative for the HPV genome. Sequence analysis revealed that HPV types 16 and 18 are the most frequent ones identified in this study. Conclusion. The prevalence of HPV in esophageal cancer can vary depending on the geographical location and other factors. Based on the findings of this study, HPV infection may possibly have contributed to an increased risk of esophageal cancer in a group of patients in Tabriz.
Dry Needling and Antithrombotic Drugs
Authors: Muñoz María , Dommerholt Jan , Pérez-Palomares Sara , Herrero Pablo , Calvo Sandra
Published: January 2022

Many clinicians increasingly use dry needling in clinical practice. However, whether patients’ intake of antithrombotic drugs should be considered as a contraindication for dry needling has not been investigated to date. As far as we know, there are no publications in analyzing the intake of antiplatelet or anticoagulant agents in the context of dry needling techniques. A thorough analysis of existing medications and how they may impact various needling approaches may contribute to improved evidence-informed clinical practice. The primary purpose of this paper is to review the current knowledge of antithrombotic therapy in the context of dry needling. In addition, reviewing guidelines of other needling approaches, such as electromyography, acupuncture, botulinum toxin infiltration, and neck ultrasound-guided fine-needle aspiration biopsy, may provide specific insights relevant for dry needling. Based on published data, taking antithrombotic medication should not be considered an absolute contraindication for dry needling techniques. As long as specific dry needling and individual risks are properly considered, it does not change the risk and safety profile of dry needling. Under specific circumstances, the use of ultrasound guidance is recommended when available.
Valsartan Regulates PI3K/AKT Pathways through lncRNA GASL1 to Improve Isoproterenol-Induced Heart Failure
Authors: Zhou Jian , Duan Xiujuan , Wang Jibing , Feng Yunhong , Yuan Jiangyong
Published: January 2022

Objective. This study is aimed at determining the expression and function of the GASL1 and PI3K/AKT pathways in isoproterenol- (ISO-) induced heart failure (HF). To determine the moderating effect of valsartan (VAL) on the progression of ISO-induced HF and to elucidate the related mechanism. Materials and Methods. First, in in vivo experiment, we examined the effect of VAL on cardiac function in rats with ISO-induced HF. Similarly, quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were used to detect the effect of VAL on ISO-treated rat primary cardiomyocytes. Then, si-GASL1-transfected primary cardiomyocytes were constructed and Ad-si-GASL1 was injected through rat tail vein to achieve the effect of lowering GASL1 expression, so as to investigate the role of GASL1 in VAL’s treatment of ISO-induced HF. Results. In ISO-induced HF rat models, the GASL1 decreased while PI3K and p-AKT expressions were abnormally elevated and cardiac function deteriorated, and VAL was able to reverse these changes. In primary cardiomyocytes, ISO induces apoptosis of cardiomyocytes, and expression of GASL1 decreased while PI3K and p-AKT were abnormally elevated, which can be reversed by VAL. The transfection of primary cardiomyocytes with si-GASL1 confirmed that GASL1 affected the expression of PI3K, p-AKT, and the apoptosis of primary cardiomyocytes. Rat myocardium injected with Ad-si-GASL1 was found to aggravate the cardiac function improved by VAL. Conclusions. This study was the first to confirm that VAL improves ISO-induced HF by regulating the PI3K/AKT pathway through GASL1. And this study demonstrated a significant correlation between HF, VAL, GASL1, and the PI3K/AKT pathway.
A Meta-Analysis on the Effectiveness of Video Laryngoscopy versus Laryngoscopy for Emergency Orotracheal Intubation
Authors: Ba Xiaotong
Published: January 2022

Background. Video laryngoscopy has been associated with some orotracheal intubations and enhances the glottic view at time of laryngoscopy and the success rate of the intubation in patients from the emergency department and the intensive care unit. In usual cases, direct laryngoscopy is performed among the patients from the emergency department or the intensive care unit. In this systematic review and meta-analysis, we draw the comparison between the video laryngoscopy and direct laryngoscopy for the emergency orotracheal intubation. Objective. The objective of the study was to identify the clinical efficacy of video laryngoscopy versus laryngoscopy for emergency orotracheal intubation. Materials and Methods. MEDLINE, CENTRAL, EMBASE, and Web of Science databases were analyzed from 2003 to 2020. Keywords used for searching the studies were “laryngoscopy,” “video laryngoscopy,” “direct laryngoscopy,” “emergency department,” “intensive care unit,” “orotracheal,” “video laryngoscope,” “glidescope,” “airway scope,” “airway,” “Macintosh laryngoscopy,” “airway management,” “tracheal intubation,” “orotracheal intubation,” and “intubation.” Results. The first-pass intubation success rates in the intensive care unit were low in video laryngoscopy with 95% CI 1.21 (1.13–1.30) and heterogeneity I2 = 78% favoring direct laryngoscopy nonsignificantly with low heterogeneity. Odds ratio for airway trauma or dental damage was 0.67, 95% CI (0.18–2.54), reported higher in video laryngoscopy. Complications with oesophageal laryngoscopy were higher in video laryngoscopy with risk ratio 0.16, 95% CI (0.09–0.29), odds ratio 0.88, 95% CI (0.65–1.18) for sever hypoxemia, risk ratio 1.53, 95% CI (1.02–2.28) for cardiovascular collapse, risk ratio with 95% CI 1.11 (0.59–2.07) for aspiration complications, and odds ratio 1.32, 95% CI (0.95, 1.85) for Inexperienced medical staff handling laryngoscopy. Conclusion. No significant efficiency was noticed in using video laryngoscopy when compared with direct laryngoscopy with the available data. The data reported in studies are not enough for efficient clinical analysis of the benefits of using video laryngoscopy over direct laryngoscopy. Thus, information such as length of stay, mortality, sever complications, and length of hospital stay must be reported.
Analyzing Relationship between Financing Constraints, Entrepreneurship, and Agricultural Company Using AI-Based Decision Support System
Authors: Liu Xiaohu , Li Han , Li Hong
Published: January 2022

Decision support technology has become a key link in modern information strategy. With the deepening of research, introduced expert systems have been introduced into decision support systems. In this way, decision support systems gradually become more uncertain and capable of handling uncertainties. The development direction of decision support system is typically based on qualitative analysis. Intelligent decision support system is a system that combines decision support system with artificial intelligence technology. This study attempts to assess in an innovative way the relationship between financing constraints, entrepreneurship, and agricultural firms. The most recently proposed intelligent decision support system, AI-assisted Intelligent Decision Support System (AIIDSS), is used to predict the impact of entrepreneurship on corporate performance. The paper constructs an entrepreneurship index from five aspects: innovation, competitiveness, human capital accumulation, management capability, and adventurous spirit. The method intends to construct the Kaplan–Zingales (KZ) index to evaluate financing constraints. Through an empirical study, it was found that entrepreneurship can significantly promote the growth of listed agricultural companies. The study can drastically reduce the difficulties involved in financing constraints normally faced by agricultural companies. The impact paths include increasing agricultural company operating cash flow, improving stock liquidity, and increasing debt financing. The research suggests that if listed agricultural companies are to improve financing constraints, entrepreneurs must improve their own competitiveness and management capabilities. This will help in reasonably controlling research and development investment besides the impulse to take risks. As the growth of an enterprise relies on considering the determinants of financing constraints, this research provides an effective investigation technique. Moreover, the findings of the study will help entrepreneurs, particularly agricultural companies, to bear most of the risks and to avail most of the opportunities.
MRNA Profiling Involved in Triggering of STAT1 with Regulatory Involvement of IRF7, PTPRF, and miR-145p in Patients Suffering from Gall Bladder Carcinoma
Authors: Zhao Weiwei , Gong Yanxuan , Chen Yugang
Published: January 2022

Background. Gall Bladder Cancer (GBC) is a type of extremely malignant tumor, which has high incidences of mortality. There is rare information about its mechanisms of invasion and gene expression regulations. microRNA-155 (miR-155) has mostly been reported to be over expressed in cases of solid tumors and hematopoietic malignancies. In this study, we have investigated the role and clinical significance of miR-155 in a Chinese population suffering from GBC and compared the results with nonneoplastic inflammation. Methods. Tissue specimens were collected on 50 patients of Gall Bladder Carcinoma and 10 patients suffering from nonneoplastic inflammation who have undergone surgeries at the Department of Pathology, Renji Hospital, Shanghai, from January 2019 to January 2020. We performed profiling of miR-155 expression in both nonneoplastic and gall bladder carcinoma tissues by QRT-PCR. Results. Expression levels of miR-155 were found to be extremely high in GBC patients in comparison to the nonneoplastic tissues (

∗

P
<
0.05

), as high miRNA is correlated with TNM stages. Further results noted were that miR-145-5p expressed genes mimic the gene expression of STAT1, a downregulation of IRF7 was noted in the GBC, and an activation of STAT1 was significantly noted in carcinoma cells of the gallbladder. Downregulation of PTPRF was also noted during the expression of miR-145. Conclusions. As downregulation of IRF7 is linked with low rates of survival, it was found that gall bladder carcinoma patients may face high mortality. The STAT-1 expression of unregulated in GBC patients was also noted.
Clinical Characteristics and Antimicrobial Susceptibility of Mycobacterium intracellulare and Mycobacterium abscessus Pulmonary Diseases: A Retrospective Study
Authors: Wang Dongping , Lin Wenhong , Cheng Hongyan , Bao Xundi , Xu Dongfang , Liang Suo , Jiang Yue , Wang Chao
Published: January 2022

The incidence of nontuberculous mycobacteria (NTM) diseases is increasing every year. The present study was performed to investigate the clinical characteristics, CT findings, and drug susceptibility test (DST) results of patients diagnosed with M. intracellulare or M. abscessus nontuberculous mycobacterial pulmonary disease (NTMPD). This retrospective study included patients diagnosed with NTMPD due to M. intracellulare or M. abscessus for the first time at Anhui Chest Hospital between 01/2019 and 12/2021. The patients were grouped as M. intracellulare-NTMPD group or M. abscessus-NTMPD group. Clinical features, imaging data and DST data, were collected. Patients with M. intracellulare infection had a higher rate of acid-fast smears (66.1% vs. 45.2%,

P
=
0.032

) and a higher rate of cavitation based on pulmonary imaging (49.6% vs. 19.4%,

P
=
0.002

) than patients with M. abscessus infection, but both groups had negative TB-RNA and GeneXpert results, with no other characteristics significant differences. The results of DST showed that M. intracellulare had high susceptibility rate to moxifloxacin (95.9%), amikacin (90.1%), clarithromycin (91.7%), and rifabutin (90.1%). M. abscessus had the highest susceptibility rate to amikacin (71.0%) and clarithromycin (71.0%). The clinical features of M. intracellulare pneumopathy and M. abscessus pneumopathy are highly similar. It may be easily misdiagnosed, and therefore, early strain identification is necessary. M. intracellulare has a high susceptibility rate to moxifloxacin, amikacin, clarithromycin, and rifabutin, while M. abscessus has the highest susceptibility rate to amikacin and clarithromycin. This study provides an important clinical basis for improving the management of NTMPD.
The Effects of Using Waste Engine Oil Bottom on Physical, Rheological Properties and Composite Modification Mechanism of SBS-Modified Asphalt
Authors: Wang Yanbo , Liu Ailian , Ding Weixiang , Rao Fangping , Yuan Jun , Zhang Zhihua , Xu Zhen , Dong Chuanzhou
Published: January 2022

This research explores the effects of using waste engine oil bottom on physical, rheological properties and composite modification mechanism of SBS-modified asphalt. The SBS asphalt binder was modified by WEOB with different concentrations (2, 4, and 6 wt%). The GC-MS and FTIR spectrometry were conducted to evaluate the chemical compositions of WEOB- and WEOB-modified asphalt. RV, DSR, and BBR were tested to evaluate high- and low-temperature pavement performance. Fluorescence microscope (FM) test, bar thin layer chromatograph (BTLC) test, and AFM test were performed to evaluate the micromorphologies and modification mechanism. The test results showed that a new characteristic peak appeared in the infrared spectrum of the WEOB-modified SBS asphalt, indicating a chemical reaction in the modification process. Incorporation of WEOB improves both the high-temperature and low-temperature properties of the SBS asphalt binder. It was confirmed that with the increase of WEOB concentration, the content of colloid gradually increases, which promotes the swelling and compaction of SBS polymer network structure. Furthermore, WEOB promotes the polarity of SBS and forms graft product MAH-g-SBS with asphalt, thus inhibiting the thermal movement of asphalt molecules. On the contrary, light components have a good correlation with the surface roughness of modified asphalt; the results show that the modified asphalt has good rutting resistance.