bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistem Pendukung Keputusan Kelompok Promosi Jabatan Menggunakan Metode Fuzzy Profile Matching
Authors: Yudiana I Made , Sugiartawan Putu , Suprihanto Didit
Published: July 2022

In a corporate organization, human resources are a very important element to support progress and quality in achieving the goals of the company. The most important thing that can be done by the company, namely the employee selection process, in order to guarantee the right candidate in the right position as well. In this study, we will discuss the methods that can be applied in the career path process in an organization. Problems that often occur, such as being difficult to determine the right person to fill a position, mistargeting in the promotion process, because it is only judged from several criteria, then promotions are less transparent and not objective. By implementing a group decision support system (SPKK), where the opinions of several decision makers can be accommodated, as well as in problem solving and communication occurs in a group. This study uses the profile matching method, because it can provide an assessment of the potential of each employee candidate by comparing the employee's personal profile with the profile of the position in question, combined with fuzzy logic so that the original value obtained by the alternative remains consistent from the beginning to the ranking process. The results obtained in the form of ranking reports using the borda method, based on calculations from the fuzzy profile matching method, are expected to help company organizations to facilitate the promotion process.
Sistem Absensi Kegiatan Ormawa Berbasis QR Code
Authors: Suryawan I Wayan Dharma , Ardhiana Dewa Putu Yudhi
Published: July 2022

The attendance system has an important role in everyday life, for example in schools, universities, factories, offices, hospitals, and other places that require attendance. Various efforts have been made so that the recording of attendance can be done easily and quickly. Efforts have been made, for example, by using fingerprints, RFID, and using QR codes.   This study develops an attendance system for student organizations by using a QR code. There are two applications developed, namely a web-based system and a mobile-based system. Data management is carried out on a web-based system. Attendance input is done on a mobile-based system. Attendance input is done using a QR code. The database used is designed to maintain data integrity to minimize recording errors. The attendance system for ormawa activities has been successfully developed. The use of a QR code makes inputting timesheets easier and faster. Users simply scan the QR code to enter the timesheet.
Rancang Bangun E-Commerce Pada Toko Bravo Sports
Authors: Zamli Fitrah Faisal , Minartiningtyas Brigida Arie
Published: July 2022

Bravo Sports Store is one of the shops or businesses engaged in the trade of sports equipment. In the process of selling goods, today the store is still using a conventional system that consumers must come directly to the store to buy the desired goods.  Stores have been using technological advances to help disseminate information about goods sold by using social media such as BBM, Instagram, Facebook, and twitter. However, it is considered inefficient because of the large number of consumers. Social media is also not able to distinguish notifications between consumers who want to ask about goods and consumers who want to buy goods. In addition, the owner must also make continuous renewal of information items such as examples of quantities of goods and prices of goods which are then published back to the public. To overcome this the authors will design and build an e-commerce web.  The result of  e-commerce is a system can be used to process goods data, employee data, transaction data, order data, employee data, consumer data, and reports. Based on blackbox testing done can be concluded that has been successfully built a web e-commerce.
Analisis Spasial dari Kebutuhan Luas Lahan Pertanian dan Permukiman Provinsi Daerah Istimewa Yogyakarta
Authors: Antara I Gede Made Yudi
Published: July 2022

Pertumbuhan jumlah penduduk akan dikaitkan dengan daya dukung ruang dan daya tampungnya. Semakin banyak penduduk maka akan membutuhkan tempat untuk tinggal, pada saat yang bersamaan kita tinggal akan tetap memenuhi syarat hidup dan hal ini diterjemahkan dalam daya dukungnya Hal ini, sangat terkait dengan tata ruang untuk langkah awal dalam mengatur, mengendalikan unsur dinamis tersebut. Topik yang luas ini, diterjemahkan dalam bentuk subtopik yang khusus yakni mencermati kebutuhan lahan pertanian yang sifatnya berkelanjutan sebagai turunan dari daya dukung  terhadap kebutuhan dasar manusia dan luas permukiman sebagai turunan dari daya tampungnya. Tujuan dari penelitian ini adalah untuk mengetahui kebutuhan lahan pertanian dan permukiman masing-masing wilayah kabupaten DIY dan menganalisis dengan pendekatan keruangan dari sebaran kebutuhan luas lahan pertanian dan permukiman Provinsi DIY. Metode yang digunakan  adalah perhitungan kuantitatif menggunakan metode geometrik untuk memprediksikan kebutuhan luas lahan pertanian dan permukiman di Provinsi Yogyakarta hingga tahun 2032 maka, kabupaten yang masih dapat memenuhi kebutuhan akan lahan pertanian seimbang dengan pemenuhan kebutuhan permukiman dan pemenuhan terhadap ruang terbuka hijau  pada tahun tersebut adalah  Kabupaten Kulon Progo dan Gunung Kidul.
Vermikomposta Potasyum Uygulamasının Marulda (Lactuca sativa L.) Verim ve Bitki Besin Elementleri Miktarı Üzerine Etkisi
Authors: ÇORAPÇI Kübra , MÜFTÜOĞLU Nuray Mücellâ
Published: July 2022

Deneme, ülkemizde kullanımı ve üretimi artış gösteren vermikompostla birlikte potasyumlu gübreleme yapılmasının bitki verimi ve bitki besin elementlerinin miktarı üzerine etkisinin belirlenmesi amacı ile yürütülmüştür.

Perlitte yetiştirilen marul (Lactuca sativa L.) bitkisine sabit miktarda vermikompost ve farklı dozlarda potasyum gübrelemesi yapılarak, bitki verimi ile bitkideki makro (K, P, Ca, Mg) ve mikro (Fe, Cu, Zn, Mn) besin elementlerinin miktarı irdelenmiştir.

Araştırmada; bölgedeki bir solucan üretim tesisinden temin edilmiş olan vermikompost, ortam olarak perlit, bitki olarak marul bitkisi kullanılmıştır. Potasyum kaynağı olarak potasyum sülfat kaynaklı 0, 12.5, 25.0, 37.5 ve 50.0 kg K2O/da uygulanmıştır.

Uygulanan potasyum dozlarından verim, demir, bakır, çinko istatistiksel olarak etkilenmezken, bitkideki fosfor, potasyum, kalsiyum, magnezyum ve mangan elementlerinin istatistiksel önemde etkilendiği saptanmıştır.

Üretimi yapılan vermikompostların içeriklerinin aynı olmaması, standart bir ürün halinde bulunmamaları bu ürünün kullanımında göz önünde bulundurulmalıdır.
IBA ve BAP'nın Boysenberry Sürgün Ucunun in vitro Kültür Yoluyla Mikro Çoğaltılmasına Etkisi
Authors: ŞENER Sevinç , KURT Zehra
Published: July 2022

Boysenberry dünyadaki yetiştiriciliği hızla artan, taze tüketime ve işlenmeye olan uygun yüksek kaliteli meyvelere sahip olan önemli bir üzümsü meyvedir. Boysenberrynin çoğaltılmasında kısa sürede çok sayıda ve hastalıktan ari bitki elde edilmesi açısından mikro çoğaltım yöntemleri önem arz etmektedir. Bu çalışmada, IBA ve BAP'nın Boysenberry çeşidinin sürgün ucunun in vitro kültür yoluyla mikro çoğaltımı üzerine etkisi araştırılmıştır. Denemede IBA (0, 0.5, 1, 2 mg l-1) ve BAP (0, 1, 2 mg l-1) bitki büyüme düzenleyicilerinin farklı kombinasyonları kullanılmıştır. Çalışmada boysenberry fidanlarından alınan sürgün uçlarının başlangıç aşamasında MS ortamında 2 hafta gelişmesi sağlanmış ve alt kültüre alınan örneklere IBA ve BAP'nın farklı konsantrasyonları uygulanmıştır. Çalışmada bitki büyüme düzenleyicilerinin bitkilerin büyüme ve gelişmesi üzerine etkisini belirlemek amacıyla bitkilerde sürgün uzunluğu, gövde çapı, yaprak sayısı, yaprak eni ve boyu, yaş ve kuru sürgün ağırlığı, klorofil indexi ölçümleri yapılmıştır. Yapılan değerlendirme sonucunda IBA 0,5 mg l-1 + BAP 0 mg l-1 uygulamasından, en yüksek ortama sürgün yaş (2.05 g) ve kuru ağırlığı (0.541 g), kök yaş ağırlığı (0.58 g), kök uzunluğu (71.27 mm) ve kök sayısı (14 adet) değerleri belirlenmiştir. Bunun yanı sıra en yüksek ortalama yaprak eni (11.77 mm) ve sürgün uzunluğu (66.72 mm) değerleri ise IBA 2 mg l-1 + BAP 0 mg l-1 uygulamasında tayin edilmiştir.
Abstract From Current Literature Vol. 54 (1-2)
Authors: Habibir  Rasul Choudhury
Published: July 2022

Abstract not available

Bang Med J Khulna 2021; 54 : 28-31
Information for Authors Vol. 54 (1-2)
Authors: Habibir  Rasul Choudhury
Published: July 2022

Abstract not available

Bang Med J Khulna 2021; 54 : 32-33
Association News - 2021 Vol. 54 (1-2)
Authors: Habibir  Rasul Choudhury
Published: July 2022

Abstract not available

Bang Med J Khulna 2021; 54 : 34
PENGGUNAAN EKSTRAK BUAH KECUBUNG SEBAGAI AGEN EUTANASIA MENCIT PUTIH (MUS MUSCULUS)
Authors: Aprira Aprira
Published: July 2022

Mencit Putih (mus musculus) adalah hewan uji yang paling sering di gunakan di laboratorium pada kegiatan praktikum dan penelitian. Selama ini proses mematikan hewan uji mencit mutih menggunakan bahan kimia yaitu chloroform. Penelitian ini berrtujuan untuk  memanfaatkan ekstrak etanol buah kecubung sebagai bahan euthanasia pada mencit putih (mus musculus) serta nengetahui berapa volume ekstrak yang efektif mematikan mencit putih.  Penelitian ini menggunakan metode dekstiktif dan eksperimen yaitu di mulai dari studi literature, dan pembuatan ekstrak buah kecubung dengan langkah yaitu pengeringan simplisia, lalu penghalusan dan perendaman (maserasi) dengan alcohol teknis 96%, dan dilanjutkan dengan penyaringan. Lalu di lanjutkan dengan uji verifikasi tanaman di sub laboratorium Tumbuhan FMIPA Universitas Bengkulu, lalu dilakukan uji fitokomia (flavonoid. Alkaloid dan tanin), setelah itu ekstrak buah kecubungnnya di ujikan ke hewan uji yaitu mencit putih. Bagaimana kemampuan ekstrak etanol buah kecubung untuk mematikan mencit putih (mus musculus). lalu di bandingan dengan euthanasia menggunakan cloroform.  di observasi tingkah laku mencit putih dan dianalia dengan penyekoran tingkah laku dari mencit. Hasilnya adalah ekstrak etanol buah kecubung  dapat menggantikan kloroform sebagai agen euthanasia mencit dengan volume 25 m dan lama waktu 30 menit. Serta volume ekstrak sangat mempengaruhi toksisitas pada mencit, dari hasil penelitian semakin tinggi konsentrasi ekstrak buah kecubung semakin cepat kematian tikus putih.
PERBAIKAN TATA LETAK FASILITAS DENGAN METODE SYSTEMATIC LAYOUT PLANNING (SLP) UNTUK MENGURANGI JARAK PERPINDAHAN MATERIAL (STUDI KASUS UKM KERUPUK KAROMAH)
Authors: Saputra Bayu , ARifin, ST, MT Zaenal , Merjani Abdullah
Published: July 2022

This study aims to improve the layout of facilities to reduce the distance of material transfer in Karomah Crackers SMEs by using the Systematic Layout Planning (SLP) method in which the procedure consists of three stages, the analysis phase covering the material flow analysis Activity Relationship Chart (ARC) analysis, Activity Analysis Relationship Diagram (ARD), analysis of the needs of the area and available area. The adjustment phase includes the planning of room relationship diagrams and alternative layout plans. The evaluation stage was carried out by selecting alternative layout designs. Based on the Systematic Layout Planning (SLP) method, 3 proposal layouts were produced, all of which had minimized the distance. Layout I can save a distance of 11%. Proposed Layout II saves a distance of 35% and the proposed layout III can save a distance of 30%. So that the layout of proposal I is recommended as a chosen proposal layout.
DESAIN ALAT SORTIR TELUR IKAN GURAMI YANG MATI MENGGUNAKAN METODE QUALITI FUNCTION DEPLOYMENT (QFD) UNTUK MENGURANGI KERUSAKAN TELUR (STUDY KASUS DI UKM AMIRA FISH)
Authors: Muttaqin Ikhwan , Afma Vera Methalina , Widodo Bambang Wahyu
Published: July 2022

Usaha kecil menengah (UKM) dari waktu kewaktu mengalami perkembangan yang cukup pesat. Di kota Batam sangat jarang ditemui Ikan Gurami, hanya pasar tertentu atau toserba, tertentu yang menjual Ikan Gurami. Hal inilah yang menginspirasi seorang Bapak yang bernama Pak Mu’it pemilik UKM AMIRA FISH. Namun ada beberapa faktor yang mempengaruhi kualitas telur ikan gurami yaitu pada proses penyortiran dengan menggunakan alat yang kurang tepat yaitu sendok makan, hal tersebut dapat mempengaruhi pada saat penyortiran karena guncangan air dan terkontaminasinya air yang dapat mempengaruhi kualitas telur sehingga banyak telur ikan yang mati.                Desain alat sortir telur ikan gurami menggunakan metode QFD dilakukan karena, QFD dapat membuat produk berdasarkan keinginan serta kebutuhan para pengguna. Perancangan produk dengan metode QFD membutuhkan customer voices untuk menyusun matriks pada House of Quality. Kebutuhan primer bagi para pengguna yang didapat dari customer voices ini intinya akan akan dijadikan dasar untuk mendesain dan membuat alat sortir telur ikan gurami. Setelah melakukan desain, alat sortir telur ikan gurami kemudian di desain lagi menggunakan software solid works.                Alat sortir telur ikan gurami ini diharapkan mampu untuk mengurangi kerusakan pada proses penyortiran telur ikan gurami menjadi 10.5% dari alat yang sebelumnya yaitu 29%.
Implementasi Overall Equipment Effectiveness ( OEE ) Dalam Penerapan Metode Total Productive Maintenance (TPM) di PT. FJT
Authors: Arifin, ST., MT Zaenal
Published: July 2022

Industry Sector of Vertical transportation, especially in the factory of PT. FJT, manufacturing system improvement is one of the efforts to increase that must be done intensively so that the results can respond to market changes quickly. The company always tries to increase productivity, one of the ways that has been done is to implement preventive and corrective maintenance. But in reality, the results have not reached expectations. Research on the Numerical Controll Turret machine in this company found that the time allocated to do damage maintenance is a major problem, so most of the corrective action is focused on this problem. This study uses OEE measurements, analysis of the calculation of the Six Great Losses, and also a causal diagram to look for existing problems and to provide suggestions for improvement for those problems. The measurement result obtained by OEE is 72.02%, the biggest factor influencing the low effectiveness of Mesen NCT is the 37.77% engine breakdown, which is the biggest among the 6 causal factors. .
ANALISA PENGENDALIAN PERSEDIAN BAHAN BAKU KEMASAN CUP 240 ML DENGAN MENGGUNAKAN METODE EOQ (ECONOMIC ORDER QUANTITY) DI PT. DEF BATAM
Authors: Sumarya Edi
Published: July 2022

Penelitian ini dilakukan terhadap persediaan bahan baku kemasan cup 240 ml untuk mengetahui  jumlah pembelian yang optimum pada bahan baku kemasan cup 240 ml dengan menggunakan metode EOQ (Economic Order Quantity), untuk mengetahui persediaan pengaman (Safety Stock) pada bulan Juli tahun 2018 sampai dengan Juni 2019 di PT DEF Batam. Untuk mengetahui: Kapan seharusnya melakukan pemesanan kembali (Re Order Point), untuk mengetahui perbandingan yang lebih optimum antara menggunakan Total Inventory Cost (“TIC) yang ditetapan perusahaan dengan total biaya persediaan atau Total Inventory Cost (TIC) menggunakan metode EOQ (Economic Order Quantity). Metode yang digunakan adalah metode kualitatif. Hasil penelitian ini menunjukan bahwa:  jumlah pemesanan kemasan cup  240 ml yang optimum pada bulan Juli tahun 2018 – Juni 2019 adalah 15941350 pcs, setiap kali pemesanan, dan frequensi pemesanan dilakukan dua kali dalam satu tahun.  Jumlah Safety Stock dalam bulan Juli tahun 2018 – Juni 2019 adalah sebesar 63050 pcs. Re Order Point yang harus dilakukan kembali oleh perusahaan pada tahun 2018-2019 adalah ketika persediaan bahan kemasan cup sebesar 443080 pcs. Perbandingan Total inventory Cost (TIC) Perusahaan sebesar Rp. 437.661.800 dengan Total Inventory Cost (TIC) EOQ sebesar Rp 162601730
Europeana: Aggregating Cultural Diversity In Unity
Authors: Adiba Syifa , Febriyanto Febriyanto
Published: July 2022

This study examines Europeana, a European cultural heritage data aggregator. The purpose of this study is to explore the Europeana platform and its relationship in a broader field. The purpose of this research is to provide an overview of Europeana development and demonstrate the significant alteration in the platform. A qualitative approach used in this study is descriptive methods and direct observation to Europeana website, alongside with literature review was conducted for the data retrieval technique. The research found that Europeana experienced a significance in the development and has several objectives, but more importantly emphasized more on creation, production and distribution process of digital heritage content in Europe. As a result, Europeana has a significant effect on cultural heritage sustainability through work closely with digitization to present the tacit knowledge in the public sphere and preserve cultural heritage object.
Clinical Benefits of Amniotic Membrane Contact Lens
Authors: Jeong Hyun Chul , Lee Jae Hun , Choi Soo Young , Kim Sung Po , Park Wan Ki , Park Woo Chan
Published: July 2022

Purpose: To investigate the clinical efficacy of MS-Amnion amniotic membrane contact lenses.Methods: MS-Amnion amniotic membrane contact lenses were placed for 1 week in patients with severe superficial punctate keratitis or corneal epithelial defects that did not respond to medical treatment. Eighteen eyes followed-up for ≥3 months were evaluated in terms of the best-corrected visual acuity, tear break-up time, and corneal sensation and opacity before and after application of the MS-Amnion amniotic membrane contact lens. The success and recurrence rates, and complications during follow-up, were recorded.Results: Out of 18 eyes, 15 (83.3%) healed within 2 weeks without any treatment other than the amniotic membrane; three eyes (16.7%) were unresponsive, and thus underwent temporary amniotic membrane transplantation. Recurrence developed in three eyes (20%). The amniotic membrane contact lens dropped out in five eyes (27.8%) and folded over in two (11.1%). The mean best-corrected visual acuity improved from 0.89 to 0.27 logarithm of the minimal angle of resolution after 3 months, while the mean corneal opacity decreased from 0.38 to 0.11 after 3 months; the changes were statistically significant. The tear break-up time and corneal sensation also improved, but they were not statistically significant. We encountered no significant complications.Conclusions: The MS-Amnion amniotic membrane contact lenses can heal the amniotic membrane and do not require suturing when applied in the outpatient clinic. This may be beneficial for patients with intractable ocular surface disorders.
Clinical Manifestation of Infectious Keratitis in Ocular Graft Versus Host Disease
Authors: Jin Hyung Nam , Kim JongHwa , Yoon Hyeon Jeong , Yoon Kyung-Chul
Published: July 2022

Purpose: We evaluated the clinical manifestations of, and risk factors for, infectious keratitis in patients with ocular graft-versus-host disease (GVHD).Methods: A total of 11 patients who developed infectious keratitis after a diagnosis of ocular GVHD between January 2015 and December 2020, and 36 who did not (the control group), were included in this retrospective study. We recorded sex, age, any underlying disease, any other organ affected by systemic GVHD, systemic immunosuppressant use, follow-up duration, clinical manifestations, the severity of ocular GVHD prior to infection, the size of the epithelial defect, the depth of infiltration, hypopyon status, and the results of microbiological tests. Systemic and ocular indices (including systemic GVHD status) were compared using the chi-squared test. Risk factors for infection were identified.Results: Of the corneal indices, the presence of corneal filaments, the extent of corneal neovascularization, and the number of corneal epithelial defects were significantly higher in the infected group (p = 0.023, p = 0.004, and p = 0.001, respectively). GVHD severity was also significantly higher in that group (p < 0.001). The presence of corneal filaments, corneal neovascularization, and corneal epithelial defects prior to infection correlated significantly with the risk of infection (p = 0.046, p = 0.010, and p = 0.003, respectively). Multivariate analysis identified corneal epithelial defects as a significant risk factor for infection (p = 0.029).Conclusions: In patients with ocular GVHD, corneal epithelial defects, corneal neovascularization, and corneal filaments prior to infection were associated with the development of infection. In particular, corneal epithelial defects before infection was a significant risk factor for infection.
Compressive Optic Neuropathy Caused by Internal Carotid Artery Aneurysm Presenting with Concurrent Neuromyelitis Optica
Authors: Lim Yeon Ju , Lee Soo Jung
Published: July 2022

Purpose: To report a case of compressive optic neuropathy caused by an internal carotid artery aneurysm accompanied by concurrent neuromyelitis optica (NMO).Case summary: A 48-year-old female presented with sudden painless blurry vision in the inferior visual field of her right eye for 2 days. The corrected visual acuity was 0.7 in the right eye, and a relative afferent pupillary defect was observed. The visual field test demonstrated an inferior altitudinal defect in the right eye, while the color vision test was normal. However, after 5 days, she developed decreased color vision. Optic nerve enhancement in the right eye was observed on orbital magnetic resonance imaging, and anti-aquaporin-4 antibody was positive. She was diagnosed with NMO, and high-dose steroids were administered intravenously. In addition, brain magnetic resonance angiography showed a 5-mm aneurysm in the ophthalmic segment of the right internal carotid artery, which was compressing the optic nerve. Coil embolization of the aneurysm was performed. On the fourth day of steroid therapy and the first day after coiling, the corrected visual acuity in the right eye improved to 1.0. At 6-week follow-up, color vision and visual field defect also showed complete recovery.Conclusions: In this rare case of internal carotid artery aneurysm combined with NMO, early active treatment led to complete recovery of visual acuity and field defects.
REPRESENTATION BEFORE THE ADMINISTRATIVE AUTHORITIES
Authors: ÇEBİ BUĞDAYCI Melike Özge
Published: July 2022

Representation, which is one of the most important principles of the administrative procedure, can be defined as the representation of persons affected by the administrative procedure before the administration through a representative. The right to be represented before the administrative authorities, as well as the disciplinary sanctions in which the right of defense is important, ensure the participation of relevant parties in the administrative procedure that affects his/her legal situation. In this respect, the representation serves many administrative procedural principles, especially the right to be heard, and ensures the active participation of individuals in the administrative procedure. The representation before the administrative authorities, which finds a legal basis within the scope of the administrative procedure laws accepted in most of the modern states under the rule of law, has no legal basis in Turkish law, except for representation by a lawyer. In judicial decisions, the issue is mostly evaluated within the scope of the right of defense. Considering the international regulations on the subject, it should be accepted that if an individual or regulatory administrative act that may directly and negatively affect the rights or interests of the individual is not benefited from the assistance of a representative during the administrative procedure, the administrative act will become unlawful.
PUBLIC SOCIAL ASSISTANCE AND SOCIAL SERVICES FOR PEOPLE WITH DISABILITIES
Authors: BULUŞ Sıdıka
Published: July 2022

Social security is a right that everyone should achieve in the face of increasing and diversifying risks every day. It has a special importance for people with disabilities who need support to maintain their lives on an equal footing with other people in society. In Turkish Law, there are social assistance and service regulations for individuals with disabilities who cannot benefit from social insurance. Social assistance are provided to provide income security to people in need who do not have enough income to earn a living. Since economic support is not enough for disabled people to participate in public life, adapt to society and become useful, social services have also been deemed necessary. Services such as providing care and rehabilitation services at home or in care centers for people with disabilities who need it, providing basic and vocational education are the main social services offered in terms of bringing these people into society. Individuals with disabilities are not required to pay any price to benefit from social assistance and services. In order for these social benefits and services offered to people with disabilities to achieve their goals, they must be organized in accordance with today's economic conditions, managed by specialists and implemented fairly, regardless of the difference between people.
Giant appetites: exploring the trophic ecology of California’s largest kelp forest predator, the giant sea bass Stereolepis gigas
Authors: Blincow KM , Swalethorp R , Ramírez-Valdez A , Semmens BX
Published: July 2022

The recovery of endangered predators has the potential to influence the ecosystems they inhabit. After suffering severe population declines due to fishing pressure, giant sea bassStereolepis gigasin southern California, USA, are beginning to recover. As large-bodied predators often associated with the kelp forest and rocky reef environments of southern California and Baja California, Mexico, the local recovery of this species could influence trophic dynamics in these systems. Here we leverage stable isotope and gut content analysis to describe the trophic ecology of adult giant sea bass. We found that they are generalist predators, with larger individuals relying more heavily on macroalgae-derived carbon, occupying a larger trophic niche, and obtaining higher trophic positions. Using these results, we speculate about the relationship between giant sea bass and kelp forest ecosystems, a vulnerable yet key habitat, including the impact of the return of these predators, as well as how contemporary threats to kelp forests might mediate their continued recovery.
What kind of mathematics for doorsmeer student fits for in solving a mathematical problem: A discussion about student’s informal mathematics
Authors: Putra Mulia , Novita Rita , Usman Usman
Published: July 2022

Penelitian ini bertujuan untuk mengidentifikasi matematika informal siswa dan cara guru dalam menyelesaikan masalah matematika informal tersebut. Penelitian ini melibatkan 5 orang guru dan 1 orang siswa yang bekerja pada perusahaan pencuci sepeda motor. Sebagai gambaran, matematika seorang pekerja (siswa) doorsmeer (pekerjaannya mencuci motor), yang dianggap sebagai jenis matematika di luar sekolah (matematika informal) bisa menyelesaikan masalah matematika siswa yang terkait dengan kegiatan keseharian siswa yang bekerja pada tempat doorsmeer. Akan tetapi, matematika formal yang digunakan oleh guru dan yang diajarkan di sekolah, tidak bisa menyelesaikan masalah yang sesuai dengan realita yang dihadapi siswa doorsmeer, walaupun algoritmanya sudah benar. Sebagai kesimpulan, guru matematika mengira bahwa matematika yang dipelajari di sekolah sudah cocok untuk siswa yang bekerja di doorsmeer dengan kata lain, matematika yang diberikan di sekolah bisa aplikasikan di tempat siswa bekerja. Akan tetapi, cara matematika yang diaplikasikan oleh siswa doorsmeer tidak sama dengan matematika yang diajarkan oleh guru di sekolah yang berpikir bahwa matematika sekolah cocok di tempat siswa bekerja.
Combinatorial Geometric Series and Binomial Theorems
Authors: Annamalai Chinnaraji
Published: July 2022

In today’s world, the growing complexity of computational and mathematical modelling demands the simplicity of mathematical equations for solving today’s scientific problems and challenges. This paper presents combinatorial geometric series, innovative binomial coefficients, combinatorial equations, binomial expansions, calculus with combinatorial geometric series, and its relationship and theorems. Combinatorics involves integers, factorials, binomial coefficients, discrete mathematics, and theoretical computer science for finding solutions to the problems in computing and engineering science. The combinatorial geometric series with binomial expansions and its theorems refer to the methodological advances which are useful for researchers who are working in computational science. Computational science is a rapidly growing multi-and inter-disciplinary area where science, engineering, computation, mathematics, and collaboration use advance computing capabilities to understand and solve the most complex real life problems.
Note on the Riemann Hypothesis
Authors: Vega Frank
Published: July 2022

The Riemann Hypothesis is a conjecture that the Riemann zeta function has its zeros only at the negative even integers and complex numbers with real part $\frac{1}{2}$. In 2011, Sol{\'e} and and Planat stated that the Riemann Hypothesis is true if and only if the inequality $\prod_{q\leq q_{n}}\left(1+\frac{1}{q} \right) >\frac{e^{\gamma}}{\zeta(2)}\times \log\theta(q_{n})$ is satisfied for all primes $q_{n}> 3$, where $\theta(x)$ is the Chebyshev function, $\gamma\approx 0.57721$ is the Euler-Mascheroni constant and $\zeta(x)$ is the Riemann zeta function. Using this result, we create a new criterion for the Riemann Hypothesis. We prove the Riemann Hypothesis is true using this new criterion.
The specialty of allergy and clinical immunology in Brazil
Authors: de Mello Luane Marques , Serpa Faradiba Sarquis , Chiabai Joseane , Fernandes Fátima Rodrigues , Chong-Neto Herberto José , Sarinho Emanuel Sávio Cavalcanti , Rubini Norma de Paula Motta , Solé Dirceu
Published: July 2022

Objective

To assess the profile of allergist/immunologist (A/I) physicians in Brazil, the workplace, the access to diagnostic and therapeutic procedures, and the impact of the COVID-19 pandemic on professional practice.

Methods

This cross-sectional study was conducted as an online survey. All adhering members of the Brazilian Association of Allergy and Immunology (ASBAI) received a Google Forms tool by email. The questionnaire addressed sociodemographic and professional aspects of the Brazilian allergists/immunologists (A/I) daily routine. The information was analyzed by SPSS version 20.0.

Results

Four hundred and sixty members answered the questionnaire. Women were predominant among the responders (336; 73%), and the median age was 47 years (range, 27–82 years). Most participants worked in the private sector (437, 95%), whereas 256 (47%) worked in the public sector. Among the public sector employees, 210 (82%) reported having access to some diagnostic test for allergic diseases and inborn errors of immunity. Only 91 (35%) A/I physicians in the public system had access to allergen-specific immunotherapy, compared to 416 (95, 9%) of those in the private sector. Regarding biological drugs, 135 (52.7%) and 314 (71.9%) of the A/I physicians working in the public and private sector, respectively, reported access. Two hundred and eighty-three (61.6%) had at least a 50% reduction in the number of consultations, and 245 (56%) provided telemedicine care during the COVID-19 pandemic.

Conclusion

Brazilian A/I have incorporated the most recent advances in managing immunoallergic diseases into their clinical practice, but they still have little access to various diagnostic methods. Strategies to enable the presence of A/I in public health services should be discussed and implemented. The coronavirus pandemic has accelerated the incorporation of telemedicine as a viable and promising method of medical care and can expand access to the specialty.
genomeSidekick: A user-friendly epigenomics data analysis tool
Authors: Chen Junjie , Zhu Ashley J. , Packard René R. S. , Vondriska Thomas M. , Chapski Douglas J.
Published: July 2022

Recent advances in epigenomics measurements have resulted in a preponderance of genomic sequencing datasets that require focused analyses to discover mechanisms governing biological processes. In addition, multiple epigenomics experiments are typically performed within the same study, thereby increasing the complexity and difficulty of making meaningful inferences from large datasets. One gap in the sequencing data analysis pipeline is the availability of tools to efficiently browse genomic data for scientists that do not have bioinformatics training. To bridge this gap, we developed genomeSidekick, a graphical user interface written in R that allows researchers to perform bespoke analyses on their transcriptomic and chromatin accessibility or chromatin immunoprecipitation data without the need for command line tools. Importantly, genomeSidekick outputs lists of up- and downregulated genes or chromatin features with differential accessibility or occupancy; visualizes omics data using interactive volcano plots; performs Gene Ontology analyses locally; and queries PubMed for selected gene candidates for further evaluation. Outputs can be saved using the user interface and the code underlying genomeSidekick can be edited for custom analyses. In summary, genomeSidekick brings wet lab scientists and bioinformaticians into a shared fluency with the end goal of driving mechanistic discovery.
Identification of the prognostic signature based on genomic instability-related alternative splicing in colorectal cancer and its regulatory network
Authors: Ding Qiuying , Hou Zhengping , Zhao Zhibo , Chen Yao , Zhao Lei , Xiang Yue
Published: July 2022

Background: Colorectal cancer (CRC) is a heterogeneous disease with many somatic mutations defining its genomic instability. Alternative Splicing (AS) events, are essential for maintaining genomic instability. However, the role of genomic instability-related AS events in CRC has not been investigated.

Methods: From The Cancer Genome Atlas (TCGA) program, we obtained the splicing profiles, the single nucleotide polymorphism, transcriptomics, and clinical information of CRC. Combining somatic mutation and AS events data, a genomic instability-related AS signature was constructed for CRC. Mutations analyses, clinical stratification analyses, and multivariate Cox regression analyses evaluated this signature in training set. Subsequently, we validated the sensitivity and specificity of this prognostic signature using a test set and the entire TCGA dataset. We constructed a nomogram for the prognosis prediction of CRC patients. Differentially infiltrating immune cells were screened by using CIBERSORT. Inmmunophenoscore (IPS) analysis was used to evaluate the response of immunotherapy. The AS events-related splicing factors (SF) were analyzed by Pearson’s correlation. The effects of SF regulating the prognostic AS events in proliferation and migration were validated in Caco2 cells.

Results: A prognostic signature consisting of seven AS events (PDHA1-88633-ES, KIAA1522-1632-AP, TATDN1-85088-ES, PRMT1-51042-ES, VEZT-23786-ES, AIG1-77972-AT, and PHF11-25891-AP) was constructed. Patients in the high-risk score group showed a higher somatic mutation. The genomic instability risk score was an independent variable associated with overall survival (OS), with a hazard ratio of a risk score of 1.537. The area under the curve of receiver operator characteristic curve of the genomic instability risk score in predicting the OS of CRC patients was 0.733. Furthermore, a nomogram was established and could be used clinically to stratify patients to predict prognosis. Patients defined as high-risk by this signature showed a lower proportion of eosinophils than the low-risk group. Patients with low risk were more sensitive to anti-CTLA4 immunotherapy. Additionally, HSPA1A and FAM50B were two SF regulating the OS-related AS. Downregulation of HSPA1A and FAM50B inhibited the proliferation and migration of Caco2 cells.

Conclusion: We constructed an ideal prognostic signature reflecting the genomic instability and OS of CRC patients. HSPA1A and FAM50B were verified as two important SF regulating the OS-related AS.
Antioxidant, Cytotoxic, and Antimicrobial Potential of Silver Nanoparticles Synthesized using Tradescantia pallida Extract
Authors: Shahzadi Irum , Aziz Shah Syed Munawar , Shah Mohammad Maroof , Ismail Tariq , Fatima Nighat , Siddique Maria , Waheed Ummara , Baig Ayesha , Ayaz Aisha
Published: July 2022

Silver nanoparticles have received much attention, due to their wide range of biological applications as an alternative therapy for disease conditions utilizing the nanobiotechnology domain for synthesis. The current study was performed to examine the antioxidant, anticancer, antibacterial, and antifungal potential of biosynthesized silver nanoparticles (TpAgNPs) using plant extract. The TpAgNPs were produced by reacting the Tradescantia pallida extract and AgNO3 solution in nine various concentration ratios subjected to bioactivities profiling. According to the current findings, plant extract comprising phenolics, flavonoids, and especially anthocyanins played a critical role in the production of TpAgNPs. UV–visible spectroscopy also validated the TpAgNP formation in the peak range of 401–441 nm. Further, the silver ion stabilization by phytochemicals, face-centered cubic structure, crystal size, and spherical morphology of TpAgNPs were analyzed by FTIR, XRD, and SEM. Among all TpAgNPs, the biosynthesized TpAgNP6 with a medium concentration ratio (5:10) and the plant extract had effective antioxidant potentials of 77.2 ± 1.0% and 45.1 ± 0.5% free radical scavenging activity, respectively. The cytotoxic activity of TpAgNP6 in comparison to plant extract for the rhabdomyosarcoma cell line was significantly the lowest with IC50 values of 81.5 ± 1.9 and 90.59 ± 1.6 μg/ml and cell viability % of 24.3 ± 1.62 and 27.4 ± 1.05, respectively. The antibacterial and antifungal results of TpAgNPs revealed significant improvement in comparison to plant extract, i.e., minimum inhibition concentration (MIC) 64 μg/ml against Gram-negative Pseudomonas aeruginosa while, in the case of antifungal assay, TpAgNP6 was active against Candida parapsilosis. These TpAgNPs play a crucial role in determining the therapeutic potential of T. pallida due to their biological efficacy.
Nanoscale Porphyrin Metal-Organic Frameworks Deliver siRNA for Alleviating Early Pulmonary Fibrosis in Acute Lung Injury
Authors: Weng Changmei , Li Guanhua , Zhang Dongdong , Duan Zhaoxia , Chen Kuijun , Zhang Jieyuan , Li Tao , Wang Jianmin
Published: July 2022

Acute lung injury (ALI) has high mortality and still lacks novel and efficient therapies. Zinc finger E-box binding homeobox 1 and 2 (ZEB1/2) are highly expressed in the early stage of ALI and are positively correlated with the progression of pulmonary fibrosis. Herein, we developed a nanoscale Zr(IV)-based porphyrin metal-organic (ZPM) framework to deliver small interfering ZEB1/2 (siZEB1/2) to alleviate early pulmonary fibrosis during ALI. This pH-responsive nano-ZPM system could effectively protect siRNAs during lung delivery until after internalization and rapidly trigger siRNA release under the mildly acidic environment of the endo/lysosome (pH 4.0–6.5) for transfection and gene silencing. Furthermore, the in vivo studies confirmed that this nano-ZPM system could anchor in inflamed lungs. Moreover, the ZEB1/2 silencing led to increased E-cadherin and decreased α-SMA levels. Overall, the nano-ZPM system was an excellent non-viral vector system to deliver siRNAs to alleviate early pulmonary fibrosis during ALI.
Uncoupling of Mitosis and Cytokinesis Upon a Prolonged Arrest in Metaphase Is Influenced by Protein Phosphatases and Mitotic Transcription in Fission Yeast
Authors: Chica Nathalia , Portantier Marina , Nyquist-Andersen Mari , Espada-Burriel Silvia , Lopez-Aviles Sandra
Published: July 2022

Depletion of the Anaphase-Promoting Complex/Cyclosome (APC/C) activator Cdc20 arrests cells in metaphase with high levels of the mitotic cyclin (Cyclin B) and the Separase inhibitor Securin. In mammalian cells this arrest has been exploited for the treatment of cancer with drugs that engage the spindle assembly checkpoint and, recently, with chemical inhibitors of the APC/C. While most cells arrested in mitosis for prolonged periods undergo apoptosis, others skip cytokinesis and enter G1 with unsegregated chromosomes. This process, known as mitotic slippage, generates aneuploidy and increases genomic instability in the cancer cell. Here, we analyze the behavior of fission yeast cells arrested in mitosis through the transcriptional silencing of the Cdc20 homolog slp1. While depletion of slp1 readily halts cells in metaphase, this arrest is only transient and a majority of cells eventually undergo cytokinesis and show steady mitotic dephosphorylation. Notably, this occurs in the absence of Cyclin B (Cdc13) degradation. We investigate the involvement of phosphatase activity in these events and demonstrate that PP2A-B55Pab1 is required to prevent septation and, during the arrest, its CDK-mediated inhibition facilitates the induction of cytokinesis. In contrast, deletion of PP2A-B56Par1 completely abrogates septation. We show that this effect is partly due to this mutant entering mitosis with reduced CDK activity. Interestingly, both PP2A-B55Pab1 and PP2A-B56Par1, as well as Clp1 (the homolog of the budding yeast mitotic phosphatase Cdc14) are required for the dephosphorylation of mitotic substrates during the escape. Finally, we show that the mitotic transcriptional wave controlled by the RFX transcription factor Sak1 facilitates the induction of cytokinesis and also requires the activity of PP2A-B56Par1 in a mechanism independent of CDK.
Zebrafish models of inflammation in hematopoietic development and disease
Authors: Ketharnathan Sarada , Rajan Vinothkumar , Prykhozhij Sergey V. , Berman Jason N.
Published: July 2022

Zebrafish offer an excellent tool for studying the vertebrate hematopoietic system thanks to a highly conserved and rapidly developing hematopoietic program, genetic amenability, optical transparency, and experimental accessibility. Zebrafish studies have contributed to our understanding of hematopoiesis, a complex process regulated by signaling cues, inflammation being crucial among them. Hematopoietic stem cells (HSCs) are multipotent cells producing all the functional blood cells, including immune cells. HSCs respond to inflammation during infection and malignancy by proliferating and producing the blood cells in demand for a specific scenario. We first focus on how inflammation plays a crucial part in steady-state HSC development and describe the critical role of the inflammasome complex in regulating HSC expansion and balanced lineage production. Next, we review zebrafish studies of inflammatory innate immune mechanisms focusing on interferon signaling and the downstream JAK-STAT pathway. We also highlight insights gained from zebrafish models harbouring genetic perturbations in the role of inflammation in hematopoietic disorders such as bone marrow failure, myelodysplastic syndrome, and myeloid leukemia. Indeed, inflammation has been recently identified as a potential driver of clonal hematopoiesis and leukemogenesis, where cells acquire somatic mutations that provide a proliferative advantage in the presence of inflammation. Important insights in this area come from mutant zebrafish studies showing that hematopoietic differentiation can be compromised by epigenetic dysregulation and the aberrant induction of signaling pathways.
Synthesis and Biological Evaluation of 3-(Pyridine-3-yl)-2-Oxazolidinone Derivatives as Antibacterial Agents
Authors: Jin Bo , Wang Tong , Chen Jia-yi , Liu Xiao-qing , Zhang Yi-xin , Zhang Xiu-ying , Sheng Zun-lai , Yang Hong-Liang
Published: July 2022

In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives was designed, synthesized, and evaluated for in vitro antibacterial activity, which included bacteriostatic, morphological, kinetic studies, and molecular docking. The results demonstrated that compounds 21b, 21d, 21e and 21f exhibited strong antibacterial activity similar to that of linezolid toward five Gram-positive bacteria. After observing the effect of the drug on the morphology and growth dynamics of the bacteria, the possible modes of action were predicted by molecular docking. Furthermore, the antibiofilm activity and the potential drug resistance assay was proceeded. These compounds exhibited universal antibiofilm activity and compound 21d showed significant concentration-dependent inhibition of biofilm formation. Compound 21d also showed a stable effect on S. pneumoniae (ATCC 49619) with less drug resistance growth for 15 days, which is much longer than that of linezolid. Overall, these results can be used to guide further exploration of novel antimicrobial agents.
Synthesis and Characterization of P-PPD-Ph-Conjugated Flame Retardant
Authors: Sun Junzhuo , Zhang Daohai , Wei Ke , Tan Fang , He Min , Bao Dongmei , Qin Shuhao
Published: July 2022

The conjugated flame retardants have rarely been studied. A conjugate flame-retardant 4, 4'-{1″, 4″-phenylene-bis [amino- (10‴-oxy10‴-hydro-9‴-hydrogen- 10‴λ5-phosphaphenanthrene-10″-yl)-methyl]}-diphenol (P-PPD-Ph) was synthesized and added into the polylactic acid (PLA) matrix. The P-PPD-Ph-conjugated flame-retardant structure was tested by FTIR, 1H, and 31P NMR analysis. The thermal and rheological properties of PLA/P-PPD-PH-conjugated flame-retardant composites were investigated. The results showed that P-PPD-Ph-conjugated flame retardant affects PLA/P-PPD-PH-conjugated flame-retardant composites for promoting the formation of a carbon layer when the P-PPD-Ph-conjugated flame-retardant content was 15% and the residual carbon ratio for PLA/P-PPD-PH-conjugated flame-retardant composites increased by 4.2%.
Making Direct Air Capture Affordable; Technology, Market and Regulatory Approaches
Authors: Beaumont Maximus L. L.
Published: July 2022

Direct Air Capture (DAC) is an important solution to curb global warming and enable a circular economy. As fossil fuels dwindle, carbon for commodities such as plastic, cement, steel and liquid fuel, will need to come from somewhere. With the low cost of industrial CO2 (roughly $80 a ton) as well as the low value of most carbon credits, making DAC-produced CO2 competitive at scale is almost impossible. But what if we could scale DAC processes in markets that make sense now, building on learnings as we go while making industries less carbon intensive? The first such application is air quality and energy efficiency in indoor spaces. DAC technology can stabilize CO2 and water levels inside indoor environments to enhance the recirculation rate of internal air, thereby saving significant energy for the HVAC. Another application is the use of small-scale DAC units—providing CO2 at the scale of kilos a day rather than tons, taking advantage of the high CO2 price at that scale as well as B2C markets that otherwise rely on bottled CO2. The approach is called Decentralised DAC or DDAC (analogous to decentralised solar). DAC processes need to be developed but to scale our learnings and drive down costs, we must fund R&D and introduce a significant carbon tax. Finally, interesting new developments such as electro-swing and humidity-swing carbon capture, have the potential to drastically decrease the energy footprint of DAC (its main cost driver), paving the way to making DAC affordable.