bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodological approach to mutually agreed corporate image management and economic security of enterprise
Authors: Rudenko Inna , Kolesnyk Alina , Bolotova Tetiana , Bogoyavlenskiy Oleg , Halkina Olha , Pustova Viktoriia , Darmostuk Denis
Published: May 2021

The object of research: corporate image and enterprise economic security.

Investigated problem: methodical approach to mutually agreed management of enterprise’s image and its economic security.

The main scientific results: theoretical analysis of the opinions, which are presented in the scientific literature of enterprise economic security functional components and the mechanism of their formation, is carried out. The functional components of economic security related to the internal and external aspects of enterprise are studied in detail, and their close relationship with image components is determined. The stages of enterprise image management are schematically shown with taking into account the compliance of image economic security components levels.

The area of practical use of the research results: the need to adhere to certain sequence of actions aimed at forming a positive image and managing it in enterprises is emphasized. It is advisable to use an approach to the formation of corporate image with taking into account the targeted influence of management entities on the business environment.

Technological innovation: the enterprise economic security structure in the context of modern tendencies is proposed, the complex of measures which are recommended to be applied for enterprise image maintenance is determined.

Scope of application for technological innovation: practical activity of Ukrainian enterprises is in interconnection with other business environment participants.
The use of the topics and vocabulary of the Second World War in the Russian-Ukrainian conflict 2014-2020 (analysis of foreign historiography)
Authors: Semenenko Valeriy , Radchenko Liudmyla , Rudenko Svitlana , Kobzieva Iryna , Nikolaienko-Lomakina Alla , Rezenkina Nataliia
Published: May 2021

The object of research is the latest English literature of scientists and analysts in Western Europe and America, devoted to the problems of the information war waged by the Kremlin authorities against Ukraine. It is the problems, events of the Second World War, in the Russian-speaking academic space and the media that are still referred to only as the Great Patriotic War that became the leitmotif of these actions. Moreover, the history of the war is used precisely speculatively, that is, a careful selection of facts and conclusions is carried out, which are adjusted to certain conceptual foundations.

Investigated problem. As a result of a critical analysis of the works of Western authors, the problem posed in this work is solved: to show the objectivity and evidence of the narratives of foreign authors on the biased presentation of the topics and vocabulary of World War II about the events in the East of Ukraine in 2014-2020.

Main scientific results. The main scientific result of the study is the conclusion that Western scientists are deeply immersed in the vicissitudes of the conflict, debunking the biased evidence of Russian experts, fascist tendencies are imposed on the basis of false accusations of Ukraine, although such processes have not been recorded by any foreign analysts and observers. One of the stereotypes of Russian propaganda is the reproach for the massive "banderization" of the consciousness of citizens, but at the same time the face and activities of the leader of the OUN (b) are deliberately distorted. Modern studios of historians, diplomats, analysts of Western Europe, the USA, Canada are convincingly criticizing the political and ideological measures of Moscow aimed at discrediting the Ukrainian people. It is emphasized that the process of "nationalization" of history in Ukraine, especially during the Second World War by the Russian establishment, was used in a fraudulent way to tarnish the past of Ukraine. It was noted that, despite all the efforts of the Russian information and propaganda machine, Moscow fails to achieve the desire for results.

Scope of practical application. The research results, which are innovative in nature, can be used in both cognitive and educational values.
Temple Uspenija of the Virgin as a means of influence on the formation of national identities of Ukrainians
Authors: Radchenko Lyudmyla , Pobyvanets Vladimir , Pobyvanets Vitaliy
Published: May 2021

Based on the analysis of the development of Christianity on the example of Zolotonosha (Left Bank Dnieper) the history of Orthodox churches is studied. The place of the Zolotonosha Assumption Cathedral in the spiritual and moral life of the Ukrainian people is substantiated. The role of the church in increasing the social activation of the Orthodox Christian personality and social development of Zolotonosha region is proved.
The object of research: the Temple Uspenija of the Virgin as a historical, architectural and spiritual monument of Ukraine, its impact on public consciousness in the formation of the national identity of Ukrainians.
Investigated problem: the development of Ukrainian Orthodoxy on the example of Zolotonosha as an effective means of forming the national identity of Ukrainians and a significant factor in the democratization of society on the basis of Christian values, which increases the morality and spirituality of the people.
The main scientific results: the integral history of orthodox churches of Zolotonosha region is analyzed on the basis of data of researchers and local historians, archival church documents. The place of Zolotonosha sanctuary as one of the largest temples of Central Ukraine in the formation of the spiritual culture of the Ukrainian people is substantiated. The role of the Holy Dormition Cathedral in increasing the social activation of the Orthodox Christian personality and social development of Zolotonosha region during its history is revealed.
The area of practical use of the research results: the results of the study can be used by public administration and local government in determining public policy in the field of religion, mechanisms for solving its current problems, during the development and teaching of courses on public administration, history of religion, world history and history of Ukraine.
Innovative technological product: on the basis of fragmentary data of researchers and local historians, numerous archival church materials and documents, some of which are introduced into scientific circulation for the first time, a significant gap in ideas about the holistic picture of the history of Zolotonosha Assumption Cathedral as a historical, architectural and spiritual monument of Ukraine was filled for 70 years had been prohibited. The place of the Temple Uspenija of the Virgin in the spiritual and moral life of an Orthodox Christian is substantiated. The role of the Zolotonosha Church in the formation of the national identity of Ukrainians is highlighted.
Scope of the innovative technological product: theoretical research, the practice of forming the national identity of Ukrainians, a means of influencing religiosity to increase the morality and spirituality of people, the implementation and improvement of the system of state regulation by religious organizations.
A LU:−16 individual with antibodies
Authors: Éthier C. , Parent C. , Lemay A.-S. , Baillargeon N. , Laflamme G. , Lavoie J. , Perreault J. , St-Louis M.
Published: May 2021

Antibodies against Lutheran blood group antigens have been observed during first-time pregnancy. Samples from a woman of African descent were tested in our immunohematology laboratory on several occasions since 2001. Her samples were phenotyped as Lu(a+b−), and anti-Lub was suspected but not identified. She was asked to make autologous donations in preparation for her delivery, which she did. In 2010, two antibodies were identified: anti-Lea and -Lub. Six years later, a third investigation was requested. This time, an antibody directed at a high-prevalence Lutheran antigen was found in addition to the anti-Lea and -Lub previously observed. Her serum was compatible with three out of five Lu(a−b−) reagent red blood cells (RBCs). One of the incompatible Lu(a−b−) reagent RBCs was known to be In(Lu) (KLF1 mutation). The genetic background of the other reagent RBC was unknown. The LU cDNA sequence analysis revealed the presence of the c.230G>A (Lua), c.679C>T (LU:–16), and a silent polymorphism c.1227G>T. Anti-Lu16 was highly suspected. This would be the fifth case of LU:–16 with antibodies reported, all within women of African heritage with the Lu(a+b−) phenotype. Hemolytic disease of the fetus and newborn was not noted in these cases.
Immunohematology

2017;33:110–113.
Berbagi Kepemimpinan dan Pelayanan: Transformasi Peran Ketua Kelompok di Gereja Kristen Jawa Bekasi Timur
Authors: Kristantara Johan
Published: May 2021

Abstract This article proposes a transformation of leadership in a congregation by transforming roles of cell leaders. The research departs from a concern that leadership in many churches—including Gereja Kristen Jawa (GKJ) Bekasi Timur—tends to be oriented and centralized toministerial offices (pastors, elders, and deacons). Consequently, the roles of lay leadership have not been given enough attention. This research employs an empirical-analytical approach—enquiring empirical perceptions of leadership in a congregation and analyzing them with church leadership concepts from Kevin G. Ford and E. Stanley Ott. The methods used in this research are qualitative field research (by conducting deep interviews) as well as literary research (using closelyrelated books and journal articles). The finding of this research suggests that shared leadership and ministry transforms centralized leadership(autocracy) culture, making possible various ministries to be carried out in more vital and effective ways.

Abstrak Artikel ini menawarkan transformasi kepemimpinan jemaat dengan mentransformasikan peran para ketua kelompok. Penelitian ini berangkat dari keprihatinan bahwa kepemimpinan di banyak gereja— termasuk di Gereja Kristen Jawa (GKJ) Bekasi Timur—cenderung berorientasi dan berpusat pada jabatan gerejawi (pendeta, penatua/tua-tua, dan diaken). Akibatnya, peran kepemimpinan warga jemaat biasa kurang mendapat perhatian. Artikel ini menggunakan metode empiris-analitis, yang menggali persepsi empiris kepemimpinan jemaat lalu menganalisisnya dengan konsep-konsep kepemimpinan gereja dari Kevin G. Ford dan E. Stanley Ott. Teknik yang dipakai dalam kajian ini adalah penelitian lapangan kualitatif (dengan melakukan wawancara mendalam) dan penelitian pustaka (menggunakan buku-buku dan artikel-artikel jurnal terkait). Temuan penelitian ini menunjukkan bahwa pendekatan berbagi kepemimpinan dan pelayanan memungkinkan kultur kepemimpinan yang sentralistik (otokrasi) ditransformasikan menjadi kultur desentralistik yang berbagi sehingga pelayanan-pelayanan akan berjalan secara lebih hidup dan efektif.
Perempuan dalam Injil dan dalam Teologi Moral
Authors: Mali Mateus
Published: May 2021

Abstract Feminism is one of social-moral thoughts that challenge the hegemony of patriarchy. Feminists begin their struggle with critique of male domination and ask for valorization of women’s way of thinking, feeling, and moral decisions. According to feminists, one of the communities that are insensitive of feminist issues is the Catholic Church because the church lives in a patriarchal system. Methodology used in this article is hermeneutic. In the light of Jesus’ way, moral theology tries to reflect the problem of feminism and the role of woman in the Church. The main focus of this article is the analysis of feminism in the Gospel and in moral theology. The goal of this writing is to push Catholic women to participate more in the ecclesial life and to correct the male languages of theology to be more feminine-sensitive.

Abstrak Feminisme adalah salah satu pemikiran moral sosial yang menantang hegemoni patriarkal. Para penggerak perempuan menuntut penghargaan dari cara berpikir, berperasaan, dan mengambil keputusan moral dari para perempuan dan mengkritik dominasi laki-laki. Menurut penggerak feminisme, salah satu komunitas yang melanggengkan persoalan tentang perempuan adalah Gereja Katolik karena dia hidup dalam sistem patriarkal.Metodologi yang digunakan dalam artikel ini adalah hermeneutik. Dalam terang cara Yesus, teologi moral mencoba untuk merefleksikan persoalan perempuan dan peranannya di dalam Gereja. Fokus utama dari artikel ini adalah analisa tentang feminisme di dalam Injil dan dalam teologi moral. Tujuan penulisan ini adalah mendorong perempuan Katolik untuk lebih mengambil bagian dalam kehidupan menggereja dan untuk membetulkan bahasa teologi yang terlalu bersifat laki-laki menjadi bahasa teologi yang lebih bersifat perempuan.
Critical Digital Literacy: EFL Students’ Ability to Evaluate Online Sources
Authors: Silvhiany Sary , Huzaifah Siti , Ismet Ismet
Published: May 2021

The advancement of Internet-based technologies and the new media ecology have contributed to the increased reliance on online sources in both the academic and the non-academic contexts. This study investigated how students evaluated the credibility of online information and the bias that might have influenced the content of the information. 152 EFL students responded to the online critical literacy assessment, which consisted of six tasks: evaluating the credibility of visual information, evaluating WhatsApp message, comparing and evaluating websites, distinguishing between news and sponsored content, evaluating the credibility of claim in a YouTube video, and evaluating an Instagram post. The results of the study showed that the students were easily deceived by the online information they read from various online media. They particularly struggled to detect the unsubstantiated claims from the YouTube video. Despite being a generation Z who frequently used social media and various online sources in their daily lives, the students could not critically evaluate the claims posted on these platforms. Implications of this study include the need to incorporate critical digital literacy in the language skill courses and deliberate exposure to strategies in evaluating online sources.
Sowing speed can affect distribution and yield of soybean
Authors: Bortoli Luan Felipe , Arismendi Guilherme de Almeida , Ferreira Matheus Martins , Martin Thomas Newton
Published: May 2021

The sowing speed or planting speed is referred to tractor and seeder displacement speed during the sowing. It plays a crucial role intruding distribution of plants, and consecuently yield of soybean grain. Therefore, this paper endeavors to corroborate the repercussions of the sowing speeds on the plants distribuition and grain yield. The experimental design consisted of a randomized complete block design with five treatments and four replications, with the treatments comprising of five sowing speeds (2.0, 3.1, 6.1, 7.4, 9.0 km h-1). The following parameters were evaluated:(i) distance between plants, (ii) double spacing, acceptable spacing and failing spacing, (iii) number and dry mass of nodules, (iv) plant population, (v) shoot dry mass, (vi) mass of one thousand grains, and (vii) grain yield. With the increase in the sowing speed, the equidistance of plants in the row was changed, which in turn decreased the soybean yield. The results showed that seeding speeds close to 4.0 km h-1 provided better uniformity and distribution of plants in the row. The results also unveiled that sowing speed mainly influence the plants distribution, having greater influence on the productivity components, thereby affecting the overall soybean grain yield
Selection of soybean genotypes for yield, size, and oil and protein contents
Authors: Finoto Everton Luis , Soares Maria Beatriz Bernardes , Albuquerque José de Anchieta Alves de , Neto João Luiz Lopes Monteiro , Maia Sonicley da Silva , Doná Ségio , Chagas Edvan Alves , Silva Edgley Soares-da- , Rodríguez Carlos Abanto-
Published: May 2021

A set of experiments was developed involving a randomized block design with three replications to evaluate 17 soybean genotypes for yield, size, and oil and protein contents. Soybean genotypes Conquista, CD 223 AP, Elite, Garantia, Bioagro, M-Soy 8400, M-soy 8001, Nambu, Sambaíba, Esplendor, UFVS 2006, UFVS 2005, UFVTN 102, UVF 18, UFV 16, Valiosa RR, and Vencedora were tested. The genotypes were compared and correlated with the following variables: plant height (PH), first pod height (FPH), yield, and oil and protein contents. The genotypes with the highest PH and FPH were Sambaíba, UFV 18, and Garantia, which, together with M-Soy 8001, also had the highest grain oil contents of 20.93, 21.16, 21.02, and 21.95, respectively. Genotype Bioagro had the highest grain protein content, and the genotypes Elite and Nambu were the most productive. Oil content had a negative correlation with protein content, and yield had a positive correlation with plant size in the evaluated soybean genotypes.
Soybean (Glycine max (L.) Merrill) is one of the main oilseeds produced in the world, and is being used in the production of oils, cosmetics, and human and animal feed, making the plant highly important for the economic development of producing and consuming countries. In Brazil, soybean development has occurred effectively through genetic breeding programs, which have increased yield through the selection of genotypes adapted to the edaphoclimatic conditions of each region (Vasconcelos et al., 2015; Finoto et al., 2017)
Soil conditioners as candidates to mitigate salt/water stress effects on sorghum growth and soil properties
Authors: Silva Mayara Mariana Alves da , Pessoa Luiz Guilherme Medeiros , Simplício Josimar Bento , Souza Wagner Luís da Silva , Freire Maria Betânia Galvão dos Santos , Souza Eduardo Soares de , Santos Eduardo Silva dos , Miranda Márcio Fléquisson Alves , Júnior Caetano Claudio Pereira
Published: May 2021

In arid and semiarid regions the use of saline water is common in agricultural irrigation, due to the scarcity of high-quality irrigation water. Thus, agriculture faces a challenge in developing strategies to grow crops under such adverse conditions in these regions. The objectives of this research are to study soil chemical properties and sorghum growth response to saline irrigation levels and application of soil conditioners. A greenhouse experiment (4x5) was carried out using a Cambisol cultivated with sorghum and irrigated with five saline water levels: 100%, 80%, 60%, 40% and 20% of soil field capacity (FC). Soils were treated with no soil conditioner (control), organic matter, elemental sulfur (S0) + organic matter and gypsum + organic matter, applied to the soils 30 days before sorghum planting. At 60 days after plant emergence, measurements were recorded for: leaf water potential, plant dry weight, soil P availability, and soil chemical properties. Increasing saline water levels reduced exchangeable and soluble cations and saline variables. Organic matter + elemental sulfur promoted the highest levels of P in the soil and soil saturation extract. This mixture and the saline irrigation of 60% of field capacity promoted the greatest plant growth. However the organic matter + gypsum mixture promoted higher leaf water potential in relation to the other conditioners tested. The saline irrigation level equivalent to 60% of field capacity and the incorporation of organic matter + S0 were sufficient to reduce soil salinity and sodicity, maintaining P and soluble/exchangeable cations contents to a level that best promoted sorghum growth
Cover crops and multifunctional microorganisms can affect development of upland rice
Authors: Araujo Fernando Couto de , Nascente Adriano Stephan , Filippi Marta Cristina Corsi de , Silva Mariana Aguiar , Sousa Vinícius Silva , Lanna Anna Cristina
Published: May 2021

Cultivation of cover crops in the off-season and the use of multifunctional microorganisms are strategic technologies to ensure sustainability in upland rice production. The objective of this work was to determine the effect of mix of cover crops cultivated in the off-season and multifunctional microorganisms on the growth promotion of upland rice plants, under no-tillage systems conducted in the Brazilian Cerrado. The experimental design was a complete randomized blocks in a 6x2 factorial scheme with four replications. The treatments consisted of a combination of six soil covering plants 1. Fallow (control); 2. millet (Pennisetum glaucum) and crotalaria (Crotalaria juncea, C. spectabilis and C. ochroleuca); 3. millet and pigeon pea (Cajanus cajanus); 4. millet and Urochoa ruziziensis; 5. millet, U. ruziziensis and pigeon pea; and 6. millet and buckwheat (Fagopyrum esculentum)), with or without the application of coinoculants 1301 (Bacillus sp.) + Azospirillum sp. The mix of cover crops millet + U. ruziziensis and millet + U. ruziziensis + pigeon pea recorded the largest biomass production and the highest nutrient content in the straw. Rice plants cultivated after millet + pigeon pea showed largest transpiration and stomata conductance. The application of multifunctional microorganisms contributed to an increase of 29% in the photosynthetic rates of rice plants. The highest upland rice grain yield was achieved after mix of millet + crotalaria (Crotalaria juncea, C. spectabilis and C. ochroleuca). The application of multifunctional microorganisms increased the mass of 1000 grains, but does not affect rice grain yield. Our results showed that cover crops significantly affected rice grain yield and the multifunctional microorganisms affected grain quality
Relationship Between Gender and Performance on Emotion Perception Tasks in a Latino Population
Authors: Cavieres Alvaro , Maldonado Rocío , Bland Amy , Elliott Rebecca
Published: May 2021

Basic emotions are universally recognized, although differences across cultures and between genders have been described. We report results in two emotion recognition tasks, in a sample of healthy adults from Chile. Methods: 192 volunteers (mean 31.58 years, s.d. 8.36; 106 women) completed the Emotional Recognition Task, in which they were asked to identify a briefly displayed emotion, and the Emotional Intensity Morphing Task, in which they viewed faces with increasing or decreasing emotional intensity and indicated when they either detected or no longer detected the emotion. Results: All emotions were recognized at above chance levels. The only sex differences present showed men performed better at identifying anger (p = .0485), and responded more slowly to fear (p = .0057), than women. Discussion: These findings are consistent with some, though not all, prior literature on emotion perception. Crucially, we report data on emotional perception in a healthy adult Latino population for the first time, which contributes to emerging literature on cultural differences in affective processing.
Are Asian exchanges outliers? A market quality criterion
Authors: R. Chakravarty Ranjan , Pani Sudhanshu
Published: May 2021

This paper provides a practical, empirical and theoretical framework that allows investment managers to evaluate stock exchanges’ market quality when choosing among different plausible international trading venues. To compare trading exchanges, it extends the hypothesis of market microstructure invariance to trading across exchanges. A measure ω, the ratio of the market-wide volatility to microstructure invariance, is introduced. The paper computes ω for the exchanges around the world. Its value for the NSE (India) is 24.5%, the Korea Exchange (Korea) is 7.9%, the Shanghai Exchange (China) is 3.5%, and the Shenzhen Exchange (China) is 4.4%, which is significantly different from that of major exchanges in the USA (NYSE – 0.8%, NASDAQ – 1.3%) and Europe (LSE (UK) – 0.4). This country risk dimension clearly identifies which equity exchanges cannot hold their own direct correlational hedges and therefore mandatorily require derivative positions, and has significant implications for the decision making of global long-short equity asset allocators in the Asian listed equity markets.
Use of Topical Finasteride Vs Systemic Finasteride in Male Pattern Baldness
Authors: Kumar R.V
Published: May 2021

In this study we have analyzed the use of finasteride which is a type P-selective 5a-reductase inhibitor. By decreasing dihydroxytestestrone (DHT) level, it is found to be effective in the treatment of male androgenic alopecia. In this study, we compared the effect of topical vs. systemic finasteride in the treatment of androgenic alopecia. Our study is a randomized clinical trial study having 30 male patients. They have come for alopecia treatment at Nesam hospital, Coimbatore, India. We have selected male patients with androgenic alopecia and divided them into two groups (A, B), randomly having 15 patients in each group. For group A, Topical finasteride (0.1%) with minoxidil (5%) solution was given. Group B patients received topical minoxidil with oral finasteride (1mg) tablets. All patients were regularly followed up till the end of 6 months. A Patient had a first review in the first week followed by monthly follow up. Following parameters were taken into account: size of bald area, total hair count, and terminal hair. Data was analyzed by Chi-square statistical test. Each month the terminal hair, size of bald area and hair count between the two groups were compared. In the initial few months group, A showed good improvement. But Serial measurements indicated that a significant increase in hair counts and terminal hair counts is seen in both groups. This study showed that on long term follow-up of more than 3 months, both topical and systemic finasteride groups had similar results.
Reliability of Rapid Diagnostic Tests in the Diagnosis of Malaria amongst Children attending the Outpatient Department of the Tetteh Quarshie Memorial Hospital in the Akuapem North District of the Eastern Region of Ghana
Authors: Lopez Aquel Rene
Published: May 2021

Treatment of malaria, with the appropriate diagnostic tool, helps to reduce morbidity and mortality in children. The absence of resources and inadequate labor in emerging countries like Ghana make malaria microscopy difficult. The Rapid Diagnostic Test kit (RDT) remains unpopular despite its availability and ease of use because of limited research on its effectiveness leading to over­ prescription of antimalarial drugs. This study shows how reliable the malaria diagnostic test is. Out of 132 children were recruited in all into the study with more females (59.1%) than males (40.9%). 35 (26.5%) of children who were recruited tested positive for Plasmodium falciparum with the Malaria rapid diagnostic test cassette while 97 (73.5%) children tested negative for Plasmodium falciparum with the malaria diagnostic test cassette. In Malaria Microscopy, 35 (26.5%) children tested positive while 97 (73.5%) tested negative for malaria parasites. Out of the 35 children who tested positive, RDT picked 33 as positive and 2 as negative (sensitivity = 94.3%). While out of the 97 that tested negative for microscopy, RDT picked 94 as negative and 3 as positive (specificity= 96.9%). The positive predictive value and negative predictive values are 91.7% and 97.9%, respectively.This clearly shows the Rapid Diagnostic Test (RDT) is an effective diagnostic tool for the testing of malaria in children in the Akuapem North District in the Eastern Region of Ghana.
Epicardial mapping and ablation for ventricular arrhythmias in experienced center without onsite cardiac surgery: A feasibility report
Authors: Chen Shaojie , Chun K R Julian , Bordignon Stefano , Tohoku Shota , Schmidt Boris
Published: May 2021

Objective: Epicardial access is sometimes required to effectively treat ventricular arrhythmias, but it can be associated with increased risk of procedural complications needing surgical intervention. The present study aimed to evaluate the feasibility and safety of epicardial mapping/ablation in experienced center without onsite cardiac surgery.Methods: Patients who had drug-refractory, recurrent ventricular arrhythmias were scheduled for catheter ablation. All surgeons had at least fifty pericardial puncture experiences. Epicardial puncture and perioperative anticoagulation were carried out based on institutional protocol. Phrenic nerve was mapped by 3-D mapping system. Coronary anatomy was delineated by coronary angiography.Results: A total of 44 patients (63.3 years, male 86.4%) received epicardial access. Of them 7 (15.9%) were scheduled for PVC ablation, 37 (84.1%) for VT ablation (ICM: 25%, NICM: 59.1%). Mean LVEF was 41.3%. Acute ablation success rate was 35 (79.5%). Procedural adverse events included: pericardial effusion occurred in 3 (6.8%) patients who all well treated with pericardial drainage; and pericardial tamponade in 1 (2.3%) patient requiring transfer to surgical intervention. No death, stroke, phrenic nerves palsy, or coronary artery injury were observed. Median hospitalization was 4 (3-6) days. Univariable analysis and ROC curve showed that patients’ age was a significant predictor of epicardial procedural complication (area under curve (AUC): 0.813, P=0.041).Conclusions: Guided by a tailored procedural protocol, the majority of the epicardial access related complications can be treated conservatively without needing onsite surgery. Older age is a risk factor associated with epicardial access related complications.
Time for cardiac care in pregnancy: beyond 42 days post-partum
Authors: Sliwa Karen , Mocumbi Ana
Published: May 2021

[first paragraph of article]Avoidable deaths from pregnancy complications occur on a global scale, with the greatest burden of mortality among women in low-to-middle income countries [1]. Most countries record maternal death only up to 42 days postpartum because of the assumption that avoidable death in pregnant women occurs during pregnancy or shortly thereafter. Although limited, the available data suggest otherwise.
Model Prediksi Persen Lemak Tubuh Remaja Putri: Studi Cross Sectional
Authors: Khairani Nurul , Sudiarti Trini
Published: May 2021

The purpose of this study was to get the prediction model which had optimum validity for  estimating body fat percentage of adolescent girls. The design of this study was a Cross Sectional. The sampels were 110 school girls which taken by Stratified Proportional technique. Anthropometric measurements consisted of measurements of age, weight, and height (to obtain the BMI (kg/ m2) and BMI (WHO Z Score)), waist circumference, and skinfold thickness. Body fat percentage was measured using various predictive models. Bivariate analysis used was the correlation test. Multivariate analysis used was multiple linear regression test. The ROC test was used for the validation test to determine the Area Under Curve (AUC) value, sensitivity, specificity, Positive Predictive Value (PVP), Negative Predictive Value (PVN), Likelihood Ratio + or (LR +), and LR-. The  result  of  the study  showed  that the average of body fat percentage of samples was 26,51% ± 5,48%. The prediction model which obtained from multivariate analysis was BFP= 0,991 BMI +0,069 ST+0,249 A -1,703. Based on the validation test, the prediction model of this study had optimum validity in compared with other  prediction  models.  Tujuan dari penelitian ini adalah untuk mendapatkan model prediksi yang memiliki validitas optimal untuk memperkirakan persen lemak tubuhremaja putri. Desain  penelitian adalah Cross Sectional. Sampel yang diambil sebanyak 110 siswi dengan  menggunakan teknik Stratifikasi Proporsi. Pengukuran antropometri terdiri dari pengukuran usia, berat badan dan tinggi badan (untuk mendapatkan nilai IMT (kg/m2) dan IMT WHO Z Score), lingkar pinggang, dan skinfold thickness. Persen lemak tubuh diukur dengan menggunakan berbagai model prediksi. Analisis bivariat menggunakan uji korelasi. Analisis multivariat menggunakan uji regresi linier ganda. Uji ROC digunakan untuk uji validasi untuk mengetahui nilai Area Under Curve (AUC), sensitivitas, spesifisitas, Predictive Value Positif (PVP), Predictive Value Negative (PVN), Likelihood  Ratio + atau  (LR+), dan LR-. Hasil penelitian menunjukkan bahwa rerata persen lemak tubuh   responden adalah  26,51 %   ±  5,48 %. Model prediksi  yang  didapatkan dari hasil multivariat adalah PLT=  0,991 IMT  + 0,069 ST + 0,249 U -1,703. Berdasarkan hasil  uji  validasi, model prediksi tersebut  memiliki validitas optimal jika dibandingkan dengan model prediksi lainnya.
Covid-19 Salgının Sinai, Hizmetler Ve Teknoloji Endeksindeki Sektörlerin Hisse Senetlerine Olan Etkisi: BİST Örneği
Authors: Daştan Erhan
Published: May 2021

Bu çalışmanın amacı Covid-19 salgınının BİST Sınai endeksinde yer alan BİST Gıda-İçecek, BİST Hizmetler endeksinde yer alan BİST Turizm ve BİST Ulaştırma, BİST Teknoloji endeksinde yer alan BİST Bilişim şirketlerinin hisse senetlerine olan etkisini incelemektir. Sektörlerin hisse senetlerinin salgından ne yönde etkilendiklerini öğrenmek için Türkiye’de ilk vakanın görüldüğü 10 Mart 2020 tarihinin sekiz ay öncesi ve sekiz ay sonrası durumları karşılaştırılmıştır. Öncesi ve sonrası durumlarının karşılaştırılması için SPSS paket programı kullanılarak Wilcoxon testi uygulanmıştır. İhtiyaç ve talepten dolayı Gıda-İçecek ve Bilişim sektörlerinin olumlu; yasaklamalar, kısıtlamalar ve sınır kapılarının kapatılmasından dolayı ise Ulaştırma ve Turizm sektörünün olumsuz etkilenmesi, bunun da sektördeki şirketlerin hisse senetlerine yansıması beklenmektedir. Fakat elde edilen sonuçlara göre salgından Gıda-İçecek, Bilişim ve Turizm sektörlerinin hisse senetleri salgından olumlu etkilenirken, Ulaştırma ise olumsuz etkilenmiştir. Turizm sektörünün hisse senetlerinin olumlu etkilenmesinin nedenlerinin araştırılması ise ayrı bir çalışma konusu olarak düşünülmektedir.
MicroRNA in Multiple Myeloma - A Role in Pathogenesis and Prognostic Significance
Authors: Puła Anna , Robak Paweł , Robak Tadeusz
Published: May 2021

Multiple myeloma (MM) is a common malignant hematological malignancy.
Recently, interest has grown in the role of non-coding regions in disease pathogenesis. MicroRNAs
(miRNAs) are small non-coding RNAs containing 19-25 bases that play a crucial
role in messenger RNA silencing and post-transcriptional regulation of gene expression.
Several miRNAs demonstrate markedly dysregulated expression in MM, suggesting that
they may act as both tumor suppressors and oncogenes. microRNAs are also reportedly
involved in the regulation of other epigenetic mechanisms of gene expression. Additionally,
some miRNAs have been associated with drug resistance, and therefore a further exploration
of their activity may lead to its reversal. Moreover, miRNA expression patterns in
either MM cells or serum exosomes have been shown to be good prognostic markers. This
review describes the roles of miRNAs in MM and examines their potential to predict MM
prognosis and play a role in novel therapeutic strategies.
Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders
Authors: Petrella Carla , Di Certo Maria Grazia , Gabanella Francesca , Barbato Christian , Ceci Flavio Maria , Greco Antonio , Ralli Massimo , Polimeni Antonella , Angeloni Antonio , Severini Cinzia , Vitali Mario , Ferraguti Giampiero , Ceccanti Mauro , Lucarelli Marco , Severi Carola , Fiore Marco
Published: May 2021

The Mediterranean diet is worldwide recognized as a good prototype of nutrition
due to the conspicuous intake of olive oil, nuts, red wine, legumes, fruit, and vegetables, all
fundamental elements rich in antioxidant substances and polyphenols. Polyphenols are a
wide range of phytochemicals and/or synthetic chemical compounds with proven beneficial
properties for human health. In the present review, we critically summarize the wellcharacterized
antioxidant and anti-inflammatory properties of polyphenols contained in the
olives and extra virgin olive oil and of resveratrol, a non-flavonoid phenolic compound. We
discuss the potential use of these polyphenols as pharmaceutical formulations for the treatment
of human diseases. We also show the emerging importance of their consumption in
the prevention and management of crucial neurodegenerative conditions (alcohol-related
brain disorders and aging) and in neuromuscular disorders (Spinal Muscular Atrophy and
Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy), where oxidative stress
plays a predominant role.
Machine Learning in Discovery of New Antivirals and Optimization of Viral Infections Therapy
Authors: Tarasova Olga , Poroikov Vladimir
Published: May 2021

Nowadays, computational approaches play an important role in the design of new drug-like compounds and optimization of pharmacotherapeutic treatment of diseases. The emerging growth of viral infections, including those caused by the Human Immunodeficiency Virus (HIV), Ebola virus, recently detected coronavirus, and some others lead to many newly infected people with a high risk of death or severe complications. A huge amount of chemical, biological, clinical data is at the disposal of the researchers. Therefore, there are many opportunities to find the relationships between the particular features of chemical data and the antiviral activity of biologically active compounds based on machine learning approaches. Biological and clinical data can also be used for building models to predict relationships between viral genotype and drug resistance, which might help determine the clinical outcome of treatment. In the current study, we consider machine learning approaches in the antiviral research carried out during the past decade. We overview in detail the application of machine learning methods for the design of new potential antiviral agents and vaccines, drug resistance prediction and analysis of virus-host interactions. Our review also covers the perspectives of using the machine learning approaches for antiviral research including Dengue, Ebola viruses, Influenza A, Human Immunodeficiency Virus, coronaviruses and some others.
Rediscovering Potential Molecular Targets for Glioma Therapy Through the Analysis of the Cell of Origin, Microenvironment and Metabolism
Authors: Guo Xiaoran , Wang Tao , Huang Guohao , Li Ruohan , Da Costa Clive , Li Huafu , Lv Shengqing , Li Ningning
Published: May 2021

Gliomas are the most common type of malignant brain tumors. Despite significant medical
advances, gliomas remain incurable and are associated with high mortality. Although numerous
biomarkers of diagnostic value have been identified and significant progress in the prognosis of the
outcome has been made, the treatment has not been parallelly improved during the last three decades.
This review summarizes and discusses three aspects of recent discoveries related to glioma,
with the objective to highlight the advantages of glioma-specific drugs targeting the cell of origin,
microenvironment, and metabolism. Given the heterogeneous nature of gliomas, various cell populations
have been implicated as likely sources of the tumor. Depending on the mutation(s) acquired
by the cells, it is believed that neural stem/progenitor cells, oligodendrocyte progenitor cells, mature
neurons, and glial cells can initiate cell transformation into a malignant phenotype. The level
of tumorigenicity appears to be inversely correlated with the maturation of a given cell population.
The microenvironment of gliomas includes non-cancer cells such as immune cells, fibroblasts, and
cells of blood vessels, as well as secreted molecules and the extracellular matrix, and all these components
play a vital role during tumor initiation and progression. We will discuss in detail how the
tumor microenvironment can stimulate and drive the transformation of non-tumor cell populations
into tumor-supporting cells or glioma cells. Metabolic reprogramming is a key feature of gliomas
and is thought to reflect the adaptation to the increased nutritional requirements of tumor cell proliferation,
growth, and survival. Mutations in the IDH gene can shape metabolic reprogramming and
may generate some vulnerabilities in glioma cells, such as abnormal lipid metabolism and sensitivity
to endoplasmic reticulum stress (ERS). We will analyze the prominent metabolic features of malignant
gliomas and the key pathways regulating glioma metabolism. This review is intended to provide
a conceptual background for the development of glioma therapies based on the properties of
tumor cell populations, microenvironment, and metabolism.
reflection of family relations in the novel of A. Chulpan “Kecha Va Kunduz”
Authors: Sayitqulova Zilola Husniddin qizi
Published: May 2021

The present article analyzes the relationship of the couple and the role of women in couple relations in the early twentieth century by using the heroes of the great Uzbek novel “Kecha va Kunduz”, created by A. Chulpan. The images of women of three different ages in the novel were used in the analysis. Zebi is a young Uzbek woman, Miryokub's wife is a middle-aged Uzbek woman, and Kurbanbibi is an older Uzbek woman and their characteristics and commonalities are shown. Their sense of childbearing is glorified.
Interactive Model-Based Compilation
Authors: Smyth Steven Patrick
Published: May 2021

There is a growing tendency for using domain-specific languages, which help domain experts to stay focussed on abstract problem solutions. It is important to carefully design these languages and tools,
which fundamentally perform model-to-model transformations. The quality of both usually decides the effectiveness of the subsequent development and therefore the quality of the final applications. However,
as the complexity and safety requirements of modern systems grow, it becomes increasingly burdensome to create highly customized languages and difficult to provide reasonable overviews within these tools.
This thesis introduces a new interactive model-based compilation methodology. Compilations for arbitrary model-to-model transformations are themselves described as models. They can be instantiated for particular
inputs, e. g. a program, to create concrete compilation runs, which return the result of that compilation. The compilation instance is interactively observable. Intermediate results serve as new inputs and as documentation.
They can be used to create highly customized views and facilitate understandability. This methodology guides modellers from the start of the compilation to the final result so that they can interactively refine their models.
The methodology has been implemented and validated as the KIELER Compiler (KiCo) and is available as part of the KIELER open-source project. It is used to implement the current reference compiler for the
SCCharts language, a statecharts dialect designed for specifying safety-critical reactive systems based on a synchronous model of computation. The interactive model-based compilation approach was key to the
rapid prototyping of three different compilation strategies, as well as new language extensions, variations and closely related languages. The results are verified with benchmarks, which are again modelled
using the same approach and technology. The usability of the SCCharts language and the KiCo tooling is documented with long-term surveys and real-life industrial, academic and teaching examples.
Improving Management of Type 2 Diabetes Using Home-Based Telemonitoring: Cohort Study
Authors: Milani Richard , Chava Pavan , Wilt Jonathan , Entwisle Jonathan , Karam Susan , Burton Jeffrey , Blonde Lawrence
Published: May 2021

Background

Diabetes is present in 10.5% of the US population and accounts for 14.3% of all office-based physician visits made by adults. Despite this established office-based approach, the disease and its adverse outcomes including glycemic control and clinical events tend to worsen over time. Available home technology now provides accurate, reliable data that can be transmitted directly to the electronic medical record.

Objective

This study aims to evaluate the impact of a virtual, home-based diabetes management program on clinical measures of diabetes control compared to usual care.

Methods

We evaluated glycemic control and other diabetes-related measures after 1 year in 763 patients with type 2 diabetes enrolled into a home-based digital medicine diabetes program and compared them to 794 patients matched for age, sex, race, BMI, hemoglobin A1c (HbA1c), creatinine, estimated glomerular filtration rate, and insulin use in a usual care group after 1 year. Digital medicine patients completed questionnaires online, received medication management and lifestyle recommendations from a clinical pharmacist or advanced practice provider and a health coach, and were asked to submit blood glucose readings using a commercially available Bluetooth-enabled glucose meter that transmitted data directly to the electronic medical record.

Results

After 1 year, usual care patients demonstrated no significant changes in HbA1c (mean 7.3, SE 1.7 to mean 7.3, SE 1.6; P=.41) or changes in the proportion of patients with HbA1c≥9.0 (n=117, 15% to n=113, 14%; P=.51). Digital medicine patients demonstrated improvements in HbA1c (mean 7.3, SE 1.5 to mean 6.9, SE 1.2; P<.001) and significant changes in the proportion of patients with HbA1c≥9.0 (n=107, 14% to n=49, 6%; P<.001), diabetes distress (n=198, 26% to n=122, 16%; P<.001), and hypoglycemic episodes (n=313, 41.1% to n=91, 11.9%; P<.001).

Conclusions

A digital diabetes program is associated with significant improvement in glycemic control and other diabetes measures. The use of a virtual health intervention using connected devices was widely accepted across a broad range of ethnic diversity, ages, and levels of health literacy.