bluuebunny/crossref_metadata_2025 huggingface dataset:
Selection of a Fermentation Strategy for the Preparation of Clam Sauce with Acceptable Flavor Perception
Authors: Zhou Tao , Ma Yunjiao , Jiang Wei , Fu Baoshang , Xu Xianbing
Published: May 2023

Flavor, which mainly depends on volatile compounds, is an important index for evaluating the quality of clam sauce. This study investigated the volatile compounds in clam sauce prepared using four different methods and the influence of aroma characteristics. Fermenting a mixture of soybean koji and clam meat improved the flavor of the final product. Solid-phase microextraction (SPME) combined with gas chromatography-mass spectrometry (GC-MS) identified 64 volatile compounds. Nine key flavor compounds, namely, 3-methylthio-1-propanol, 2-methoxy-4-vinylphenol, phenylethyl alcohol, 1-octen-3-ol, α-methylene phenylacetaldehyde, phenyl-oxirane, 3-phenylfuran, phenylacetaldehyde, and 3-octenone, were selected using variable importance in projection (VIP). The results of the electronic nose and tongue detection of the aroma characteristics of the samples prepared by four different fermentation methods were consistent with those of GC-MS analysis. The clam sauce prepared by mixing soybean koji with fresh clam meat possessed better flavor and quality than that prepared via other methods.
Bioactive Compounds in Sea Buckthorn and their Efficacy in Preventing and Treating Metabolic Syndrome
Authors: Chen Ying , Cai Yunfei , Wang Ke , Wang Yousheng
Published: May 2023

Sea buckthorn (Hippophae rhamnoides L. or Elaeagnus rhamnoides L.) is a plant that has long been used as a Chinese herbal medicine. This species is known to contain numerous bioactive components, including polyphenols, fatty acids, vitamins, and phytosterols, which may be responsible for its medicinal value. In experiments both in vitro and in vivo (ranging from cell lines to animal models and human patients), sea buckthorn has shown positive effects on symptoms of metabolic syndrome; evidence suggests that sea buckthorn treatment can decrease blood lipid content, blood pressure, and blood sugar levels, and regulate key metabolites. This article reviews the main bioactive compounds present in sea buckthorn and discusses their efficacy in treating metabolic syndrome. Specifically, we highlight bioactive compounds isolated from distinct sea buckthorn tissues; their effects on abdominal obesity, hypertension, hyperglycemia, and dyslipidemia; and their potential mechanisms of action in clinical applications. This review provides key insight into the benefits of sea buckthorn, promoting future research of this species and expansion of sea buckthorn-based therapies for metabolic syndrome.
The Bidirectional Link between Nutritional Factors and Inflammatory Bowel Diseases: Dietary Deficits, Habits, and Recommended Interventions—A Narrative Review
Authors: Saracino Ilaria , Spisni Enzo , Imbesi Veronica , Ricci Chiara , Dussias Nikolas , Alvisi Patrizia , Gionchetti Paolo , Rizzello Fernando , Valerii Maria
Published: May 2023

Inflammatory bowel diseases comprise Crohn’s disease and ulcerative colitis, two chronic inflammatory disorders of the digestive tract that develop in adolescence and early adulthood and show a rising pattern in industrialized societies, as well as in developing countries, being strongly influenced by environmental pressures such as nutrition, pollution and lifestyle behaviors. Here, we provide a narrative review of the bidirectional link between nutritional factors and IBD, of dietary deficits observed in IBD patients due to both the disease itself and dietary habits, and of the suggested nutritional interventions. Research of the literature was conducted. Clinical and basic research studies consistently demonstrate that diet could alter the risk of developing IBD in predisposed individuals. On the other hand, dietary interventions represent a valid tool in support of conventional therapies to control IBD symptoms, rebalance states of malnutrition, promote/maintain clinical remission and improve patients’ quality of life. Although there are no official dietary guidelines for patients with IBD, they should receive nutritional advice and undergo oral, enteral, or parenteral nutritional supplementation if needed. However, the dietary management of malnutrition in IBD patients is complex; future clinical studies are required to standardize its management.
Physicochemical and In Vitro Starch Residual Digestion Structures of Extruded Maize and Sorghum Starches Added with Sodium Stearoyl Lactylate
Authors: de la Rosa-Millan Julian , Heredia-Olea Erick , Pérez-Carrillo Esther , Peña-Gómez Raquel , Serna-Saldívar Sergio O.
Published: May 2023

This research aimed to characterize the physicochemical, in vitro digestion, and structural features of digestion residues of maize and sorghum starches subjected to thermoplastic extrusion, along with the influence of Sodium Stearoyl Lactylate (SSL), to obtain improved starches for food applications and to understand their behavior when consumed as a food ingredient. The morphology of the extruded materials showed remanent starch granules when SSL was used. A higher amount of medium and large linear glucan chains were found in these particles, influencing higher thermal stability (ΔH ≈ 4 J/g) and a residual crystallinity arrangement varying from 7 to 17% in the extrudates. Such structural features were correlated with their digestibility, where slowly digestible starch (SDS) and resistant starch (RS) fractions ranged widely (from 18.28 to 27.88% and from 0.13 to 21.41%, respectively). By analyzing the data with a Principal component analysis (PCA), we found strong influences of B2 and B3 type chains on the thermal stability of the extrudates. The amylose and smaller glucan chains (A and B1) also significantly affected the emulsifying and foam stability properties. This research contributes to the molecular knowledge of starch in extruded products with broad food applications.
Non-Destructive Quality Evaluation of 80 Tomato Varieties Using Vis-NIR Spectroscopy
Authors: Duckena Lilija , Alksnis Reinis , Erdberga Ieva , Alsina Ina , Dubova Laila , Duma Mara
Published: May 2023

Traditional biochemical methods are resource- and time-consuming; therefore, there is a need for cost-effective alternatives. A spectral analysis is one of the non-destructive techniques that are more widely used for fruit quality determination; however, references are needed for traditional methods. In this study, visible and near-infrared (Vis-NIR) spectroscopy was used to analyze the internal quality attributes of tomatoes. For the first time, 80 varieties with large differences in fruit size, shape, color, and internal structure were used for an analysis. The aim of this study was to develop models suitable to predict a taste index, as well as the content of lycopene, flavonoids, β-carotene, total phenols, and dry matter of intact tomatoes based on Vis-NIR reflectance spectra. The content of phytochemicals was determined in 80 varieties of tomatoes. A total of 140 Vis-NIR reflectance spectra were obtained using the portable spectroradiometer RS-3500 (Spectral Evolution Inc.). Partial least squares regression (PLS) and multiple scatter correction (MSC) were used to develop calibration models. Our results indicated that PLS models with good prediction accuracies were obtained. The present study showed the high capability of Vis-NIR spectroscopy to determine the content of lycopene and dry matter of intact tomatoes with a determination coefficient of 0.90 for both parameters. A regression fit of R2 = 0.86, R2 = 0.84, R2 = 0.82, and R2= 0.73 was also achieved for the taste index, flavonoids, β-carotene, and total phenols, respectively.
GC-MS Coupled with Rate-All-That-Apply (RATA) to Analyse the Volatile Flavor Substances of Yellow Wine during Fermentation
Authors: Xia Di , Tan Xu , Wang Li , Li Zongjun , Hou Aixiang , Zhu Yan , Lai Ling , Wang Yuanliang
Published: May 2023

Yellow glutinous rice wine is a traditional Chinese beverage created by soaking, boiling, and fermenting glutinous rice. The majority of current studies on the flavor of yellow glutinous rice wine are based on instrumental analysis, with sensory analysis being overlooked. In this study, 36 volatile chemicals in the fermentation process of yellow wine were annotated by GC-MS and then an OPLS-DA model was built to screen out 13 distinctive substances (VIP > 1, p < 0.01). The relative odor activity value (ROAV) was calculated using the threshold values of these chemicals and 10 substances, including alcohols, esters, and aldehydes, were found as key contributors to the overall flavor of yellow wine. Following that, consumers quantified the sensory descriptors of yellow wine using rate-all-that-apply (RATA), and correspondence analysis revealed three groups of characteristic flavors and odors. Alcohols and esters were found to be key producers of flowery and fruity scents in yellow wine, according to correlation analysis. We discovered two alcohols that are rarely found in yellow wine: [R,R]-2,3-butanediol and 1-phenylethanol. The former was found to be favorably connected with wine scent and pungent odor, and its specific effect on flavor should be researched further.
Optimization of Delivery and Bioavailability of Encapsulated Caffeic Acid
Authors: Stanciauskaite Monika , Poskute Monika , Kurapkiene Vaida , Marksa Mindaugas , Jakstas Valdas , Ivanauskas Liudas , Kersiene Milda , Leskauskaite Daiva , Ramanauskiene Kristina
Published: May 2023

Caffeic acid is a widely distributed phenolic acid. It is described in the scientific literature that caffeic acid has poor solubility. The aim of this study was to improve the solubility of caffeic acid for better dissolution kinetics when administered orally. During the study, oral capsules of different compositions were modeled. The results of the disintegration test revealed that the excipients affected the disintegration time of the capsules. The excipient hypromellose prolonged the disintegration time and dissolution time of caffeic acid. The dissolution kinetics of caffeic acid from capsules depend on the chosen excipients. P407 was more effective compared to other excipients and positively affected the dissolution kinetics of caffeic acid compared to other excipients. When the capsule contained 25 mg of β-cyclodextrin, 85% of the caffeic acid was released after 60 min. When the capsule contained 25–50 mg poloxamer 407, more than 85.0% of the caffeic acid was released from capsules after 30 min. The research results showed that in order to improve the dissolution kinetics of caffeic acid, one of the important steps is to improve its solubility.
Potentially Synbiotic Yellow Mombin Beverages: Stability during Refrigerated Storage, Physicochemical Characteristics, and Sensory Properties
Authors: Ribeiro Luis Eduardo Guieu Galvao Telles , Batista Leonam da Silva Pereira , Assis Cristiane Fernandes de , Damasceno Karla Suzanne Florentino Silva Chaves , Sousa Júnior Francisco Canindé de
Published: May 2023

This study aimed to develop potentially synbiotic yellow mombin (Spondias mombin L.) beverages added with fructooligosaccharides and Lactiplantibacillus plantarum NRRL B-4496. Six formulations of yellow mombin beverages were prepared to measure the influence of fermentation and pH, which was adjustment to 4.5 for stability and quality parameters. Formulations were evaluated for probiotic survival, pH, titratable acidity, total phenolic compounds (TPC), and antioxidant activity for 28 days at 4 °C. Additionally, the proximate composition, color, sensory aspects, and survival to simulated gastrointestinal conditions were studied. At 21 days of storage, the viability of L. plantarum was 9 CFU/mL for the fermented symbiotic (SYNf) and non-fermented symbiotic with adjusted pH (SYNa) formulations. In addition, the fermented synbiotic with an adjusted pH beverage (SYNfA) showed a count of 8.2 log CFU/mL at 28 days. The formulations showed a high TPC (234–431 mg GAE/L), antioxidant activity (48–75 µM trolox), and a potential use as low-calorie beverages. The SYNf formulation showed an acceptability index higher than 70% and a high purchase intent. The SYNf and SYNa formulations maintained suitable probiotic counts after exposure to the simulated gastrointestinal digestion. Therefore, it was possible to develop a new potentially synbiotic yellow mombin beverage with a high sensory acceptance, supplying the market with a new functional food alternative.
Effect of Interspecific Yeast Hybrids for Secondary In-Bottle Alcoholic Fermentation of English Sparkling Wines
Authors: Marangon Matteo , Seeley Poppy , Barocci Erica , Milanowski Tony , Mayr Marangon Christine , Ricci Arianna , Bellon Jennifer , Parpinello Giuseppina P.
Published: May 2023

In sparkling winemaking, only a few yeast strains are regularly used for the secondary in-bottle alcoholic fermentation (SiBAF). Recently, advances in yeast development programs have yielded new breeds of interspecific wine yeast hybrids that ferment efficiently while producing novel flavors and aromas. In this work, the chemical and sensorial impacts of the use of interspecific yeast hybrids for SiBAF were studied using three commercial English base wines prepared for SiBAF using two commercial and four novel interspecific hybrids. After 12 months of lees aging, the chemical and macromolecular composition, phenolic profile, foaming, viscosity and sensory properties of the resulting 13 wines were assessed. Chemically, the yeast strains did not result in significant differences in the main wine parameters, while some differences in their macromolecular contents and sensory characteristics were noticeable. The foamability was mostly unaffected by the strain used; however, some effect on the foam stability was noticeable, likely due to the differences in polysaccharides released into the wines by the yeast strains. The wines exhibited different sensory characteristics in terms of aroma and bouquet, balance, finish, overall liking and preference, but these were mostly attributable to the differences in the base wines rather than the strain used for SiBAF. Novel interspecific yeast hybrids can be used for the elaboration of sparkling wines, as they provided wines with chemical characteristics, flavor and aroma attributes similar to those of commonly used commercial Saccharomyces cerevisiae strains.
Sodium Salt of Partially Carboxymethylated Sodium Alginate-g-Poly(acrylonitrile): I. Photo-Induced Synthesis, Characterization, and Alkaline Hydrolysis
Authors: Trivedi Jignesh , Chourasia Arvind
Published: May 2023

An efficient redox initiating system, ceric ammonium nitrate/nitric acid, has been employed for the first time to carry out photo-induced graft copolymerization of acrylonitrile (AN) onto sodium salt of partially carboxymethylated sodium alginate, having an average degree of substitution value to be 1.10. The photo-grafting reaction conditions for maximum grafting have been systematically optimized by varying the reaction variables such as reaction time, temperature, the concentration of acrylonitrile monomer, ceric ammonium nitrate, and nitric acid, as well as the amount of the backbone. The optimum reaction conditions are obtained with a reaction time of 4 h, reaction temperature of 30 °C, acrylonitrile monomer concentration of 0.152 mol/L, initiator concentration of 5 × 10−3 mol/L, nitric acid concentration of 0.20 mol/L, amount of backbone of 0.20 (dry basis) and the total volume of the reaction system of 150 mL. The highest percentage of grafting (%G) and grafting efficiency (%GE) achieved are 316.53% and 99.31%, respectively. The optimally prepared graft copolymer, sodium salt of partially carboxymethylated sodium alginate-g-polyacrylonitrile (%G = 316.53), has been hydrolyzed in an alkaline medium (0.7N NaOH, 90–95 °C for ~2.5 h) to obtain the superabsorbent hydrogel, H–Na–PCMSA–g–PAN. The chemical structure, thermal characteristics, and morphology of the products have also been studied.
Hereditary Gastric Cancer: Single-Gene or Multigene Panel Testing? A Mono-Institutional Experience
Authors: Calvello Mariarosaria , Marabelli Monica , Gandini Sara , Marino Elena , Bernard Loris , Dal Molin Matteo , Di Cola Giulia , Zanzottera Cristina , Corso Giovanni , Fazio Nicola , Gervaso Lorenzo , Fumagalli Romario Uberto , Barberis Massimo , Guerrieri-Gonzaga Aliana , Bertario Lucio , Serrano Davide , Bonanni Bernardo
Published: May 2023

Gastric cancer (GC) has long been a ‘Cinderella’ among hereditary cancers. Until recently, single-gene testing (SGT) was the only approach to identify high-risk individuals. With the spread of multigene panel testing (MGPT), a debate arose on the involvement of other genes, particularly those pertaining to homologous recombination (HR) repair. We report our mono-institutional experience in genetic counseling and SGT for 54 GC patients, with the detection of nine pathogenic variants (PVs) (9/54:16.7%). Seven out of fifty (14%) patients who underwent SGT for unknown mutations were carriers of a PV in CDH1 (n = 3), BRCA2 (n = 2), BRCA1 (n = 1), and MSH2 (n = 1), while one patient (2%) carried two variants of unknown significance (VUSs). CDH1 and MSH2 emerged as genes involved in early-onset diffuse and later-onset intestinal GCs, respectively. We additionally conducted MGPT on 37 patients, identifying five PVs (13.5%), including three (3/5:60%) in an HR gene (BRCA2, ATM, RAD51D) and at least one VUS in 13 patients (35.1%). Comparing PV carriers and non-carriers, we observed a statistically significant difference in PVs between patients with and without family history of GC (p-value: 0.045) or Lynch-related tumors (p-value: 0.036). Genetic counseling remains central to GC risk assessment. MGPT appeared advantageous in patients with unspecific phenotypes, although it led to challenging results.
Persistence of Abscisic Acid Analogs in Plants: Chemical Control of Plant Growth and Physiology
Authors: Nguyen Christine H. , Yan Dawei , Nambara Eiji
Published: May 2023

Abscisic acid (ABA) is a plant hormone that regulates numerous plant processes, including plant growth, development, and stress physiology. ABA plays an important role in enhancing plant stress tolerance. This involves the ABA-mediated control of gene expression to increase antioxidant activities for scavenging reactive oxygen species (ROS). ABA is a fragile molecule that is rapidly isomerized by ultraviolet (UV) light and catabolized in plants. This makes it challenging to apply as a plant growth substance. ABA analogs are synthetic derivatives of ABA that alter ABA’s functions to modulate plant growth and stress physiology. Modifying functional group(s) in ABA analogs alters the potency, selectivity to receptors, and mode of action (i.e., either agonists or antagonists). Despite current advances in developing ABA analogs with high affinity to ABA receptors, it remains under investigation for its persistence in plants. The persistence of ABA analogs depends on their tolerance to catabolic and xenobiotic enzymes and light. Accumulated studies have demonstrated that the persistence of ABA analogs impacts the potency of its effect in plants. Thus, evaluating the persistence of these chemicals is a possible scheme for a better prediction of their functionality and potency in plants. Moreover, optimizing chemical administration protocols and biochemical characterization is also critical in validating the function of chemicals. Lastly, the development of chemical and genetic controls is required to acquire the stress tolerance of plants for multiple different uses.
A Genome-Wide Association Study of the Chest Circumference Trait in Xinjiang Donkeys Based on Whole-Genome Sequencing Technology
Authors: Liu Ling-Ling , Chen Bin , Chen Sheng-Lei , Liu Wu-Jun
Published: May 2023

Animal genotyping by means of genome-wide association studies is important for connecting phenotypes of interest with their underlying genetics in livestock. However, the use of whole genome sequencing to investigate chest circumference (CC) in donkeys has rarely been reported. We aimed to use the genome-wide association study approach to detect significant single nucleotide polymorphisms (SNPs) and key genes associated with chest circumference traits in Xinjiang donkeys. We assessed 112 Xinjiang donkeys in this study. The chest circumference of each was measured 2 h before milking. We re-sequenced blood samples from the Xinjiang donkeys, and genome-wide association study analyses were performed using a mixed model with the PLINK, GEMMA, and REGENIE programs. We tested 38 donkeys for candidate SNPs for genome-wide association study using three software programs. Additionally, 18 SNP markers reached genome-wide significance (p < 1.61 × 10−9). On the basis of these, 41 genes were identified. Previously proposed candidate genes for CC traits were supported by this study, including NFATC2 (Nuclear Factor of Activated T Cells 2), PROP1 (PROP Paired-Like Homeobox 1), UBB (Ubiquitin B), and HAND2 (Heart and Neural Crest Derivatives Expressed 2). These promising candidates provide a valuable resource for validating potential meat production genes and will facilitate the development of high-yielding Xinjiang donkey breeds through marker-assisted selection or gene editing.
Measurement of In-Situ Flow Rate in Borehole by Heat Pulse Flowmeter: Field-Case Study and Reflection
Authors: Liu Bing , Yan Guanxi , Ma Ye , Scheuermann Alexander
Published: May 2023

Large-scale groundwater flow modelling demands comprehensive geological investigation (GI) to accurately predict groundwater dynamics during open-cut and underground mining. Due to the existence of large-scale heterogeneity (e.g., fault and fracture) in natural geological strata (e.g., overburden soil, rock mass and coal seam), the in-situ flow measurement in boreholes, compared to laboratory seepage tests, can bring more reliable information to estimating the in-situ seepage properties (e.g., hydraulic conductivity, intrinsic permeability, transmissivity and specific yield). In this paper, a flow-measuring technique-heat pulse flowmeter (HPFM) is methodologically introduced and then practically applied for GI in the mining extension zone of Hunter Valley Operations (HVO), New South Wales, Australia. The measuring experiences, including both positive and negative outcomes, are reported and discussed with a series of datasets of in-situ flow rates measured in the selected boreholes. The pros and cons of the HPFM application in HVO are also discussed and summarised based on the user experience collected through this field trip. Finally, through a thorough reflection, some practical recommendations are provided to help other HPFM practitioners bypass all difficulties experienced on this trip. It is anticipated that valuable user information can contribute to better GI in other sites when performing this measuring technique.
Coping Mechanisms during the War in Ukraine: A Cross-Sectional Assessment among Romanian Population
Authors: Crișan Cătălina Angela , Milhem Zaki , Stretea Roland , Hossu Radu Mihai , Florean Ionuț Stelian , Cherecheș Răzvan Mircea
Published: May 2023

On 24 February 2022, the Russian Federation invaded Ukraine, starting a military conflict that soon turned into a full-scale war. The Romanians have been actively involved in helping their neighbors, causing the accumulation of emotional and mental pressure upon the Romanian population exposed to such a close military conflict. This cross-sectional study assessed, through an online survey (1586 adult Romanian residents), the primary coping mechanisms, quality of life and anxiety levels in response to the psychological trauma associated with the Russo—Ukrainian war. Based on the results, focusing on and venting emotions along with behavioral disengagement were the coping strategies that had the strongest negative impact on anxiety and well-being. On the other hand, positive reinterpretation and growth were associated with less anxiety, a higher degree of overall health and better quality of life. To the best of our knowledge, this study is the first of its kind to be performed among the Romanian population so far. Thus, we equip mental health practitioners with the tools (real-life evidence data) that will allow them to establish a more meaningful doctor—patient relationship, maximizing therapy results.
The Search for an Outcome Variable That Measures Both Quality and Processes in Cardiac Surgery: Comparing the Quality Process Index and Mortality
Authors: Hoefsmit Paulien C. , Jansen Evert K. , Does Ronald J. M. M. , Zandbergen H. Reinier
Published: May 2023

Background: The translation of a large quantity of data into valuable insights for daily clinical practice is underexplored. A considerable amount of information is overwhelming, making it difficult to distill and assess quality and processes at the hospital level. This study contributes to this necessary translation by developing a Quality Process Index that summarizes clinical data to measure quality and processes. Methods: The Quality Process Index was constructed to enable retrospective analyses of quality and process evolution from 2011 to 2021 for various surgery types in the Amsterdam Cardiosurgical Database (n = 5497). It is presented alongside mortality rates, which are the golden standard for quality measurement. The two outcome variables are compared as quality and process measurement options. Results: Results showed that the mean Quality Process Index appeared rather stable, even though analysis of variance found that the mean Quality Process Index differed significantly over the years (p < 0.001). The 30-day and 120-day mortality rates appeared to fluctuate more, but interestingly, we failed to reject the null hypothesis of equal means. The Quality Process Index and mortality rates were statistically negatively correlated, and the extent of correlation was more pronounced with the 120-day mortality rate, as computed using the Pearson correlation coefficient r (30-day rQPI,30 = −0.07, p < 0.001 and 120-day mortality rates rQPI,120 = −0.12, p < 0.001). Conclusions: The Quality Process Index seeks to address the need to translate data for quality and process improvement in healthcare. While mortality remains the most impactful outcome measure, the Quality Process Index provides a more stable and comprehensive measurement of quality and process improvement or deterioration in healthcare. Therefore, the Quality Process Index as a quantification reinforces the understanding of the definition of quality and process improvement.
Self-Reported Reasons for Activity Limitations According to Age and Sex in Community-Dwelling Stroke Survivors
Authors: Choi Young-Ah , Kim Yeo Hyung
Published: May 2023

We examined self-reported reasons for activity limitations among Korean community-dwelling stroke survivors, focusing on age and sex differences. Data from 1547 stroke survivors who participated in the Korean National Health and Nutrition Examination Survey were analysed. The study outcomes were the self-reported reasons for activity limitations, encompassing general medical factors and stroke-related problems. These reasons were compared by age (<65 vs. ≥65 years) and sex using a complex-sample chi-square test. Stroke survivors reported different musculoskeletal, medical, and neurological problems as reasons for activity limitations, which differed by age and sex. Older stroke survivors reported more problems related to dementia, memory loss, auditory problems, back or neck problems, arthritis, or leg pain than younger survivors. Women reported more psychiatric problems, headaches or dizziness, back or neck problems, arthritis, gastrointestinal problems, and dental or oral problems than men. Older and female stroke survivors reported a higher mean number of reasons for activity limitations compared to younger and male survivors. Thus, a tailored approach considering age and sex is necessary to help stroke survivors with activity limitations in the Korean community. This study highlights the importance of considering demographic factors when designing interventions to improve their quality of life.
Editorial Commentary for the Special Issue “Infectious Disease Prevention and Public Health Promotion”
Authors: Fiore Vito
Published: May 2023

HIV testing and treatment, as well as sexually transmitted infections (STIs), remain popular topics for infectious disease specialists [...]
Adlay Consumption Combined with Suspension Training Improves Blood Lipids and Pulse Wave Velocity in Middle-Aged Women
Authors: Lee Chae Kwan , Lee Jae-Hoon , Kang Shuho , Ha Min-Seong
Published: May 2023

Middle-aged women have an increased risk of chronic degenerative diseases and reduced physical strength, which can lead to decreased vascular function and an increased risk of cardiovascular disease. However, these problems can be treated or prevented with healthy nutrition and regular exercise. We focused on these benefits as recent studies have reported the potential synergistic effects of suspension training and nutrition. Therefore, in this study, we investigated the effects of 12 weeks of adlay intake and suspension training on improvements in body composition, physical fitness, blood lipids, and arterial stiffness in middle-aged women. Neither the adlay + suspension exercise (ASEG) nor suspension exercise groups (SEG) showed significant changes in body composition. Nonetheless, with respect to physical fitness, there was a difference in time among all variables except flexibility, though the ASEG showed a more significant effect than the SEG. Regarding blood lipids, significant interaction effects were found for triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, while only the ASEG significantly improved these parameters. Furthermore, pulse wave velocity was only significantly decreased in the ASEG. In summary, performing suspension exercises for 12 weeks improved physical strength in middle-aged women. Additionally, when adlay was consumed simultaneously, blood lipids and arterial stiffness were improved.
Combined Effects of Diet and Physical Activity on Inflammatory Joint Disease: A Systematic Review and Meta-Analysis
Authors: Dinas Petros C. ,   on behalf of the students of module 5104 (Introduction to Systematic Reviews), Moe Rikke Helene , Boström Carina , Kosti Rena I. , Kitas George D. , Metsios George S.
Published: May 2023

Research evidence suggests that, individually, diet and physical activity are effective interventions for reducing levels of inflammation in inflammatory joint diseases (IJD), however little is known about their combined use. This systematic review and meta-analysis aimed to examine the effects and/or associations of combined diet and physical activity interventions in IJD, specifically rheumatoid arthritis (RA) and the spondyloarthropathies (SpA) (PROSPERO registration number: CRD42022370993). Ten out of 11 eligible studies examined RA patients. We found that a combination of diet/nutrition and physical activity/exercise improved Health Assessment Questionnaire score (standardized mean difference = −1.36, confidence interval (CI) = (−2.43)−(−0.30), I2 = 90%, Z = 2.5, p = 0.01), while surprisingly they increased erythrocyte sedimentation rate (mean difference = 0.20, CI = 0.09–0.31, I2 = 0%, Z = 3.45, p < 0.01). No effects were found on C-reactive protein or weight (p > 0.05) of RA patients. We did not find studies in other IJDs that provided sufficient data for a meta-analysis. The narrative data synthesis provided limited evidence to address our research question. No firm conclusions can be made as to whether the combination of diet/nutrition and physical activity/exercise affects inflammatory load in IJDs. The results of this study can only be used as a means of highlighting the low-quality evidence in this field of investigation and the need for further and better-quality research.
Cervical Range of Motion Analysis Performed with an Accelerometer: A Study of Intersession Reliability for Dental Practice
Authors: Nota Alessandro , Pittari Laura , Gamba Laura , Monticciolo Francesco Manfredi , Lannes Alessia , Carta Carlotta , Beraldi Alessandro , Baldini Alberto , Marzo Giuseppe , Tecco Simona
Published: May 2023

During the clinical examination of subjects with temporomandibular disorders (TMDs), the dentist sometimes must evaluate the cervical spine, due to the anatomical and functional connections between the cervical portion of the spine and the stomatognathic apparatus. The accelerometer is a device that evaluates the Range of Motion (ROM) of the main movements of the head on the neck. To date, only a few studies have investigated the repeatability of the use of the accelerometer in the assessment of cervical ROM. Therefore, the present longitudinal observational study analyzed the repeatability of acquired cervical movements on a sample of volunteer subjects who underwent accelerometer testing. A sample of 32 subjects was tested twice within 14 days to assess cervical ROM using a standardized protocol based on a review of existing literature. The results show that the examination is reliable for all the positions of the jaw, except for the parameters regarding the asymmetries of rotation and bending. In conclusion, the accelerometer can be considered a reliable tool for evaluating the active cervical ROM. However, further studies will be necessary to make better evaluations.
Informed Consent in Paediatric Telemedicine: Challenge or Opportunity? A Scoping Review
Authors: Ricci Giovanna , Gibelli Filippo , Bailo Paolo , Caraffa Anna Maria , Nittari Giulio , Sirignano Ascanio
Published: May 2023

The fundamental importance of informed consent as a prerequisite for the lawfulness of the medical act is an indisputable cornerstone of clinical practice. However, the provision of effective information and the collection of informed consent presents important critical issues in the underage patient, even considering that in general terms he or she does not have the power to directly express consent, which must be provided by parents or legal guardians. These critical issues are amplified in the context of telemedicine. The present study aims, through a scoping review of the literature of the past 10 years, to outline the operational practices adopted in the collection of informed consent from children in the context of telemedicine and to identify solutions devised to address the critical issues related to the provision of adequate information to the child in this particular care setting. The results of the research show that the activity of delivering adequate information to the child, itself complex, is made even more complex by the particular setting of telemedicine, which, however, could be effectively exploited to facilitate communication with the child patient.
Pediatric Hematology and Oncology Center Integrated by Telemedicine: Experience, Challenges and First Results of a Cross Border Network
Authors: Troschke Tabea , Wieczorek Aleksandra , Kulinski Konrad , Ociepa Tomasz , Zielezinska Karolina , Lode Holger N. , Urasinski Tomasz
Published: May 2023

This article reports on the development, implementation and management of a German–Polish telemedicine network in the field of pediatric oncology and hematology in the Euroregion Pomerania. The achievements and challenges of joint medical case reviews involving patients and their care givers, as well as cross-border education activities for physicians, students and nursing staff, are presented. In addition to a progress report, the results of an evaluation of the participants and teachers, likewise the measurement of knowledge growth, are given.
Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature
Authors: Menakuru Sasmith R. , Dhillon Vijaypal S. , Salih Ahmed , Beirat Amir F.
Published: May 2023

Acquired factor X deficiency is a rare diagnosis, especially without the association of other co-existing conditions such as amyloidosis. The authors report the case of a 34-year-old male with severe frank hematuria found to have markedly prolonged prothrombin time and activated partial thromboplastin time. A mixing study showed correction utilizing normal plasma and a coagulation panel testing revealed decreased factor X activity. The patient was treated with multiple blood transfusions, fresh frozen plasma, high-dose pulse steroids, and rituximab. The patient’s condition improved during his 21-day hospital stay and was followed up every 2 weeks for 3 months. The patient’s factor X level recovered after two weeks of discharge with no other hemorrhagic episodes.
Unraveling Arbuscular Mycorrhizal Fungi Interactions in the Exotic Plant Nicotiana glauca Graham for Enhanced Soil Fertility and Alleviation of Metal Pollution
Authors: Dounas Hanane , Bouskout Mohammed , Nafidi Hiba-Allah , Alsahli Abdulaziz Abdullah , Bourhia Mohammed , Ouahmane Lahcen
Published: May 2023

The harm that invasive species cause to the environment has received a lot of attention. It is therefore appropriate that the current research was undertaken to evaluate the effects of invasion by Nicotiana glauca Graham on soil fertility by looking at (i) its contribution to the mycorrhizal potential of the soil, (ii) its impact on soil richness and diversity in terms of the arbuscular mycorrhizal fungi (AMF) community (iii), and its ability to modify the physicochemical characteristics in the invaded soil, specifically cleaning up heavy metal. The current study was conducted at Al Houz plain (Marrakesh region, Morocco), in heavily infested sites by N. glauca. The spores of AMF were isolated using the wet sieving process; the isolated spores were sorted for morphological features using a binocular microscope. The plant roots were thinned and colored before microscopic observation. The most probable number method was used to assess mycorrhizal soil infectivity. Heavy metal contamination in soils was characterized using an X-ray fluorescence spectrometer, and the pollution load index (PLI) was utilized to assess and compare the level of heavy metal contamination at each station. The ability of N. glauca to reproduce was evaluated in order to support one of its invasive characteristics. The estimate indicated that each plant might produce more than three million seeds. This significant number guarantees the plant a great capacity for reproduction and invasion. The extra-significant mycorrhizal potential, which can take the form of spores, mycelium, or vesicles that can regenerate mycorrhizae, was discovered by conducting soil analysis in the rhizospheric soils of N. glauca. This research demonstrated the strong mycotrophic capability of N. glauca and the large mycorrhizal potential of soils. Between 4.85 and 305.5 mycorrhizal propagules were considered to be the most probable number (MPN) per 100 g of dry soil. Based on color, shape and size, AMF were classified into five morphotypes corresponding to five genera. The isolated taxa of AMF with the most diverse spores were Glomus, Rhizophagus, Paraglomus, Scutellospora, and Sclerocystis. The Glomus genus was found to have spores in significant quantity. Furthermore, N. glauca demonstrated a potential involvement in the phytoremediation of damaged soils, with a high pollution load index demonstrating a particularly high accumulation of heavy metals. N. glauca is a highly mycotrophic plant that can boost soil mycorrhizal propagule stock. N. glauca has also been demonstrated to be a phytoremediation plant capable of cleansing contaminated soils. As a result, N. glauca could be considered as a prospective candidate for application in phytoremediation of polluted soils.
Winter Sports Injuries in Elite Female Athletes: A Narrative Review
Authors: Rotllan Cristina , Viscor Ginés
Published: May 2023

There is a lack of reviews covering the topic of the parallel high prevalence of injuries in female winter sport elite athletes. We aimed to review the data on incidence and patterns of injuries in female athletes participating in official competitions of winter sports. We conducted a comprehensive literature search on epidemiological data and etiological information on alpine skiing, snowboarding, ski jumping and cross-country skiing. The most common location of injury was the knee among skiers and ski jumpers and the incidence of severe ACL events was 7.6 per 100 ski racers per season (95% CI 6.6 to 8.9) in female alpine skiers. Snowboarders and cross-country skiers were more affected in the ankle and the foot. The most common cause was contact trauma with stagnant objects. The injury risk factors include training volume, knee pre-injuries, the period of the season and the technical equipment. Females are at greater risk of suffering from overuse injuries during the competitive season, as opposed to male athletes who are more likely to suffer from traumatic injuries. Our findings can be used to inform coaches and athletes and to guide future injury prevention plans.
Time-Driven Activity-Based Costing for Capturing the Complexity of Healthcare Processes: The Case of Deep Vein Thrombosis and Leg Ulcers
Authors: Rognoni Carla , Furnari Alessandro , Lugli Marzia , Maleti Oscar , Greco Alessandro , Tarricone Rosanna
Published: May 2023

Time-driven activity-based costing (TDABC) is suggested to assess costs within the value-based healthcare approach, but there is a paucity of applications in chronic diseases such as deep vein thrombosis (DVT) and leg ulcers. In this context, we applied TDABC in a cost-effectiveness analysis comparing venous stenting to compression ± anticoagulation (standard of care—SOC) from both hospital and societal perspectives in Italy. TDABC was applied to both treatments to assess costs that were included in a cost-effectiveness model. Clinical inputs were retrieved from the literature and integrated with real-world data. The Incremental Cost Utility Ratio (ICUR) of stenting compared to SOC was EUR 10,270/QALY and EUR 8962/QALY for hospital and societal perspectives, respectively. The mean cost per patient for venous stenting of EUR 5082 was higher than the Diagnosis-Related Group (DRG) reimbursement (EUR 4742). For SOC, an ulcer healing in 3 months costs EUR 1892, of which EUR 302 (16%) is borne by the patient versus a reimbursement of EUR 1132. TDABC showed that venous stenting may be cost-effective compared with SOC but that reimbursement rates may not completely cover the real costs, which are partially sustained by the patients. A more efficient policy for covering the real costs may be beneficial for both clinical centers and patients.
Barriers and Facilitators to Point-of-Care Ultrasound Use in Rural Australia
Authors: Arnold Annie C. , Fleet Richard , Lim David
Published: May 2023

This study explores the barriers and facilitators to point-of-care ultrasound (POCUS) use and adoption in rural healthcare since POCUS is a useful resource for rural clinicians to overcome the challenges associated with limited on-site clinical support, such as limited diagnostic imaging services and infrastructure. A qualitative descriptive study was employed, interviews with ten rural clinicians were conducted, and the data were analysed using the Walt and Gilson health policy framework to guide interpretation. Barriers include a lack of standardised training requirements, the cost of the devices and challenges recouping the costs of purchase and training, difficulty with the maintenance of skills, and a lack of an effective method to achieve quality assurance. Coupling POCUS with telemedicine could address the issues of the maintenance of skills and quality assurance to facilitate increased POCUS use, leading to positive patient safety and social and economic implications.
Avoidant/Restrictive Food Disorder (ARFID), Food Neophobia, Other Eating-Related Behaviours and Feeding Practices among Children with Autism Spectrum Disorder and in Non-Clinical Sample: A Preliminary Study
Authors: Kozak Agata , Czepczor-Bernat Kamila , Modrzejewska Justyna , Modrzejewska Adriana , Matusik Edyta , Matusik Paweł
Published: May 2023

Previous research shows that children with autism spectrum disorder (ASD) may experience several difficulties—including those related to eating—and this area of research needs to be explored further. This study had two main objectives: (1) comparison of the clinical (autism spectrum disorder) and non-clinical sample of children in terms of avoidant/restrictive food disorder, food neophobia, other eating-related behaviours and feeding practices; (2) assessment of selected predictors of food neophobia. The final sample included 54 children and parents from the clinical sample (ASD) and 51 from the non-clinical sample. Parents completed: the autism spectrum rating scales (ASRS), the eating disorders in youth questionnaire (EDY-Q), the children food neophobia scale (CFNS), the child eating behaviour questionnaire (CEBQ), the child feeding questionnaire (CFQ), and a socio-demographic survey. Our analysis allowed us to partially confirm the first hypothesis since the clinical sample (vs. the non-clinical group) had significantly higher scores in such variables as (a) avoidant/restrictive food disorder (ARFID), (b) food neophobia, (c) other eating-related behaviours: emotional under-eating, desire to drink, food fussiness, (d) feeding practices: pressure to eat. Moreover, our analysis of predictors of food neophobia in the clinical and non-clinical samples also allowed us to partially confirm the second hypothesis because it turned out that only in the clinical sample (vs. the non-clinical sample) were the predictors significantly associated with food neophobia, but only two of them (food fussiness and selective eating). In conclusion, our study showed that children with ASD (compared to children without this diagnosis) experience increased difficulties in eating behaviours, and their parents present a stronger intensity of the feeding practice based on pressure to eat. This study showed that feeding problems for children in the ASD sample are a significant problem, and it is still worth exploring this area in research.
Efficient Management and Scheduling of Massive Remote Sensing Image Datasets
Authors: Zhu Jiankun , Zhang Zhen , Zhao Fei , Su Haoran , Gu Zhengnan , Wang Leilei
Published: May 2023

The rapid development of remote sensing image sensor technology has led to exponential increases in available image data. The real-time scheduling of gigabyte-level images and the storage and management of massive image datasets are incredibly challenging for current hardware, networking and storage systems. This paper’s three novel strategies (ring caching, multi-threading and tile-prefetching mechanisms) are designed to comprehensively optimize the remote sensing image scheduling process from image retrieval, transmission and visualization perspectives. A novel remote sensing image management and scheduling system (RSIMSS) is designed using these three strategies as its core algorithm, the PostgreSQL database and HDFS distributed file system as its underlying storage system, and the multilayer Hilbert spatial index and image tile pyramid to organize massive remote sensing image datasets. Test results show that the RSIMSS provides efficient and stable image storage performance and allows real-time image scheduling and view roaming.