bluuebunny/crossref_metadata_2025 huggingface dataset:
Contribution des filets sociaux à l'amélioration des conditions de vie des ménages dans la province du zondoma
Authors:   DEME El Hadji Yoro and ZOUGMORE Hortense
Published: August 2023

The aim of this research was to measure the contribution of the social safety net project to the improvement of household living conditions and the development of early childhood in the province of Zondoma from 2015 to 2019. The methodological approach used is is based on field surveys with a dynamic and interactive approach that involved beneficiaries, resource persons and project managers. The results show that the Social Safety Nets project has positive effects on the economic and social level within the beneficiary community and more particularly on the beneficiary families, despite some difficulties observed in its implementation. For better consideration of early childhood in Burkinabe households with a view to breaking the intergenerational transmission of poverty, advocacy should be developed to increase funding for social protection, in order to reach all poor and vulnerable households ; set up a unified social register highlighting poor and vulnerables households with young children; coordinate the different approaches to social protection; strengthen support for beneficiaries despite degraded security conditions; and sustain the achievements through the provision of community relays after the closure of the project.
Vision miracles for daily living enhancement
Authors:   Dr. Ashwini Kumar
Published: August 2023

The burden of low vision is rapidly increasing globally, and cally, in the developing world. The study aims to more speci nal assess various commonly used low visual aids and the outcome in patients. 36 patients with low vision were examined, investigated and treated by the author in the period between Dec 2018 to April 2019, using a variety of new instruments and rehabilitation techniques. Following this, there was improvement in visual acuity in 32 patients as well as improvement in quality of living where patients were able to undertake several household and profession related tasks and activities. Through this, the author concludes that for low vision patients, following proper diagnosis, and treatment, proper rehabilitation tools and techniques are needed to bring improvement the quality of life.
How do Trained and Prospective Physiotherapists and Radiologic Technologists Face Knee Joint Effusion Profession-Specifically and Interdisciplinary?-A Cross-Sectional Study
Authors: Halbreiner Uschi
Published: August 2023

Objective: Knee osteoarthritis (OA) is often accompanied by joint effusion that requires accurate detecting and diagnosing. In an interprofessional evidence-based practice (EBP) approach to this, physiotherapists (PTs) and radiologic technologists (RTs) should be included. While researchissults regarding the 1st pillar (external clinical evidence) and the 2nd (patients´side) pillar of EBP are available, these are still missing concerning the 3rd pillar (clinical experts´ side). Therefore, the aim of this study is to investigate how PTs and RTs deal with knee joint effusion detection in the course of knee OA patients’ profession-specifically as well as how they rate the other occupational group´s competencies. Methods: An online survey consisting of open and closed questions was conducted in the period from 31st of January 2023 till 6th of March 2023 to collect data. PTs, RTs as well as physiotherapy students (PTSs) and radiologic technology students (RTSs) were defined as target groups. A structuring content analysis was used to evaluate open questions. Descriptive and inferential statistics were used to analyses closed questions. Results: PTs and PTSs determined at least one of the cardinal symptoms of inflammation, inspection, palpation, the patellar tap test, and circumference measurement as knee effusion detection possibilities in patients´ with knee OA. In contrast, the modified stroke test and the bulge sign were hardly mentioned. The majority of RTs and RTSs stated that MRI was the first-choice imaging to detect effusion followed by sonography. Focusing on specific signs in radiologic imaging modalities fluid on T2 sequences in MRI, hypoechoic area on sonography, swelling on conventional radiography, fluid accumulation on CT and radionuclide uptake on scintigraphy were frequently mentioned. Among all 4 participating occupational groups, PTs and RTs were among the top 5 mentioned professions that have knee effusion detection competencies. There is no significant difference regarding the other occupational group´s knee effusion detection competencies. The participants rated them consistently as “rather competent” most frequently. Conclusion: The authors study results indicate that there are some discrepancies among PTs, PTSs, RTs and RTSs in regard to the 1st and 3rd pillar of EBP. All occupational groups show partly contradictory or lack of in-depth knowledge regarding frequently applied and suggested diagnostic procedures in literature. Implementing relevant training formats should be considered in the future.
Salat Sahun dalam Al-Qur’an
Authors: Rofiqoh Maulidatur
Published: August 2023

One of the central themes of the Qur'an is worship. It is one of the pillars of Islam that is most widely mentioned in the Qur'an, which it shows that prayer is one of the pillars of Islam that has an important role and function in the lives of Muslims. Therefore negligence (s?h?n) in prayer is prohibited, a person in establishing prayer is required to always remember that he is praying. The focus of this paper then is on the interpretation of surah al-M?’?n  (107): 4-5 about negligence in prayer in the eyes of al Qurtubi and Sayyid Qutb. This type of research uses library research and the method used is comparative analysis, by analyzing and comparing the interpretation of Al-Jami' li Ahkam al-Qur'an and the interpretation of fi Zilal al-Qur'an. The results show that in terms of the meaning of s?h?n is relatively same, both mufassir interpret equally that the meaning of s?h?n is negligence (not focused on praying). This is because they only pray with the aim of riya'. The difference between the two interpretations is that al-Qurthubi prefers to deal with it in the context of its implementation, such as praying outside the time limit, wasting prayer and even leaving prayer. Meanwhile, Sayyid Qutbin interpreting of surah al-M?’?n  (107): 4-5, is more revealing in the spirit of the verse by prioritizing the problems of society to be solved through the al-Qur’an, namely the implications of praying s?h?n on human behaviour.
Penggunaan Ayat Al-Quran dalam Produk Pakaian Muslimah
Authors: Pole Salehudin
Published: August 2023

The change to the digital era is an extraordinary evolution of human civilization, which involves technological resources. This can be proven by the ease with which anyone can access anything through digital media. At the same time, it gave birth to various activities. One of them is the emergence of a variety of selling Muslim clothing products with modern and classic concepts which later became a market field. From 1980-1990, syar'i clothing was discriminated against. The change in the political system in 1998 had an impact on freedom of dress, especially expressing religious symbols in the use of the hijab. Muslim clothing products are also growing rapidly and become the lifestyle of the Indonesian Muslim middle-class community. In popular culture, the hijab is not merely a cover for their genitals, but also a commodity and "fashion" for them. This in the end eliminates the value of spirituality, as well as presents a new meaning of piety in religious symbols.
Analisis Wacana Kritis Adopsi Bahasa Asing dalam Al-Quran dalam Buku Arthur Jeffery (The Foreign Vocabulary of The Quran)
Authors: Hikmah Ismi Wakhidatul , Aulia Lianfin Safira
Published: August 2023

Arthur Jeffery in his book The Foreign Vocabulary of The Quran states that there are non-Arabic language (foreign languages) in the Qur'an. This raises doubts about the authenticity of the language of the Koran wherein the Koran itself says that the language of the Koran in Arabic. This study uses critical discourse analysis promoted by Norman Fairclough where this theory focuses on how language is formed and shaped from social relations and certain contexts with three dimensions of Fairclough's critical discourse analysis, namely text (text dimension), discourse practice (discursive practice), and sociocultural practice (socio-cultural practice). The results of this study are doubts about the authenticity of the language of the Qur'an were broken by Muslim scholars and Arthur Jeffery's opinion that the existence of a foreign language in the Qur'an has clearly been proven wrong with the available data from Muslim scholars. Therefore, we conclude that the language of the Qur'an is Arabic
New records of fossil deep-sea shark teeth from the Lillebælt Clay (Early–Middle Eocene) of Denmark
Authors:   Bavarian State Collection of Zoology, Munich, Germany, Pollerspöck Jürgen , Nielsen Kent Albin , Feichtinger Iris ,   University of Graz, NAWI Geocenter, Institute of Earth Sciences, Austria, Straube Nicolas ,   University Museum Bergen, Norway
Published: August 2023

This study describes for the first time a number of distinct fossil teeth documenting several deep-sea shark species from the Eocene, which were previously not recorded from the North Sea Basin, including Apristurus sp., Orthechinorhinus cf. pfeili, Deania cf. angoumeensis, Squaliolus sp., Etmopterus cf. cahuzaci and Paraetmopterus nolfi. Our findings significantly increase the deep-sea shark diversity documented from this area so far. Despite the fact that the North Sea Basin had already lost direct connections to the neighbouring marine areas in the Eocene, the fauna shows highest similarities with documented Eocene deep-sea faunas of France, Austria and northern Morocco using cluster analysis.
Influence of Parental Involvement On the Pilgrim Christian College Basic Education Students’ Developmental Skills Amisdt Global Pandemic
Authors: Edralin Melva C. , Caguimbaga Warlinda M.
Published: August 2023

Parental Involvement plays a significant part in children’s growth and development.  This study investigated the parental involvement on their children’s developmental skills.  A total of 30 parents of Pilgrim Christian College participated in the study amidst the global pandemic. A questionnaire containing the items from Epstein’s parental involvement, and ECCD checklist of basic education’s developmental skills.  Descriptive statistics and multiple regression were used to organize the data.  Findings reveal that the components of parental involvement were rated as very high, except volunteerism which was rated as high. The children’s developmental domains were rated as very high. Parental involvement significantly influenced the children’s developmental skills. The study affirms that parental involvement has greatly contributed to the development of their children’s skills, and it points to the need for the development of the children’s emotions. Parents may continue their involvement for their children’s education especially in getting and returning modules and other activities.
Influence of Peer Approval Seeking, Socio-Economic Status and Locus of Control on Academic Self-Handicapping Behaviour of Undergraduates in Oyo State, Nigeria
Authors: Sabboh Godwin Matthew , Ojo Yemi
Published: August 2023

The study investigated the influence of peer approval seeking, socio-economic status and locus of control on academic self-handicapping behaviour of undergraduates in Oyo State Descriptive survey research design was adopted in the study and five universities were selected based on distribution of universities’ ownership. Three faculties were purposively selected with a study population of 3,415. Random sampling procedure was employed using a sampling percentage of 10% to give a sample size of 341. Questionnaire was the instrument used in the collection of data and data were analysed using simple percentage, correlation, independent sample t test and regression. Results revealed that the level of academic self-handicapping behaviour of undergraduates was moderate 2.27). There was significant positive relationship between peer approval seeking and academic self-handicapping behaviour (r = 0.314, p<.05), socio-economic status (r = 0.379, p<.05), and locus of control (r = 0.343, p<.05). There was no significant difference in the academic self-handicapping behaviour of male and female undergraduates [t (339) = -2.03, p > .05]. There was a significant joint contribution of peer approval seeking, socio- economic status and locus of control on academic self-handicapping behaviour of undergraduates, (F (3, 337) = 23.282, p<0.05). There was significant relative contribution of socio-economic status (Beta = .226, t= 3.347, p<0.05), peer approval seeking (Beta = .126, t= 2.081, p<0.05) and locus of control (Beta = .135, t= 2.032, p<0.05) on academic self-handicapping behaviour. It was recommended that every counselling and career unit of each university should implement an intervention package for students in order to reduce self-handicapping behaviour that may impinge on the academic success of the students.
Evaluation of the Applications of Contemporary Facilities Management in Nigeria
Authors: Fadumo Daniel Oluwatayomi , Okoye Ngozi Marykate , Okeke Ejike Mbanefo
Published: August 2023

This study was aimed at evaluating the applications of contemporary Facilities Management in Nigeria in order to encourage massive adoption over traditional approach. Its objectives range from identifying the applications of both traditional and contemporary Facilities Management practices in Nigeria, to identifying the benefit and challenges of the Modern/contemporary practices over the older form of facility management. Traditional approach to facility management has been proved to be unsuitable and ineffective in the 21st century and at such this independent studies paper seeks to encourage the wide adoption of contemporary facilities management due to its prevailing benefits, added is numerous recommendations to challenges that it may also present since the practice is seemly new in Nigeria. Contemporary practices in facility management in Nigeria which encompasses software and mobile applications have been created to ease facility management in the modern age. Several of such application and mobile software’s were discussed and extensively discussed and un-discussed ones are available for further research.
Readability Assessment of Patient Information Texts on Amblyopia on the Websites of Major Hospitals in Turkey
Authors: Dağdelen Kenan
Published: August 2023

Especially in the last two decades, the use of internet has increased dramatically. As expected, the patient information texts on the websites of the hospitals are also read by much more people relative to the past. In this context, this paper mainly handles the readability of patient information texts on amblyopia on the websites of major hospitals in Turkey. Since the assessed texts are in Turkish, the readability assessments are carried out by Ateşman Formula which is mainly created in order to measure the readability of the texts in written in Turkish. For this purpose, the relevant information texts of the first ten hospitals that were reached as a result of typing the keyword “göz tembelliği” -which is the Turkish of “amblyopia”- on the internet search engine Google were evaluated. Average value of the Ateşman index of examined texts corresponds to the medium difficulty classification. However, the value found is quite close to the lower limit of the medium difficulty class. This reflects that the readability level of the text is relatively low. The readers of these texts consist of people from various segments of society with various levels of education. Moreover, it is highly probable that the majority of the aforementioned readership did not have a health or medical education. For all these reasons, the readability levels of these texts should be more appropriate for the readers. Various regulations can be brought by official authorities in this regard.
Recurrence of Breast Cancer Among Bangladeshi Women Using Two Serum Protein Tumor Markers, Carcinoembryonic Antigen (CEA) and Carbohydrate Antigen 15-3 (CA15-3): A Prospective Observational Study
Authors: Kawsar Maksuda , Kawser Mahbuba , Hasan Mahmud , Hossain AZM Mostaque , Alam ABM Khurshid
Published: August 2023

Patients with breast cancer may develop recurrence even after adequate primary therapy. Besides clinical examination and imaging, serum protein tumor markers (SPTMs) measurements are used for follow-up. To find out the association of two postoperative SPTMs (e.g., Carcinoembryonic antigen/CEA, Carbohydrate antigen15-3/CA15-3) with the future recurrence of breast cancer among Bangladeshi women. Prospective-observational study was conducted among purposively-selected one hundred Patients (who underwent surgery before six months) during their routine follow-up visit to an oncology/surgical setting in Dhaka Medical College Hospital, Bangladesh. Postoperative CEA (cut-off:5ng/mL) and CA15-3 (30 U/mL) were measured at a single point time by ‘chemiluminescent Immuno assay.' Patients were then followed up for one year to detect any recurrence. Quantitative and categorical variables were compared by Student’s t-test and Fisher’s exact test, respectively. Sensitivity, specificity, and AUC (Area under the curve) of both SPTMs were estimated. Most (64%) of the patients were postmenopausal (Mean-age: 49.8±12.1) with elevated CA15-3 (32%) and CEA (18%). Overall recurrence was 18%, and only CA15-3 was found to be associated with visceral (hepatic and bone) recurrence (P=0.015). The sensitivity and specificity of CEA and CA15-3 were 22.22%, 82.9%, and 66.7%, 75.6%, respectively, while combined sensitivity increased by 6.25%. The AUC of the receiver operating characteristics (ROC) curves were 0.62, 0.82, and 0.88 for CEA, CA15-3, and combination, respectively.  Postoperative CA15-3 has been shown to have the capacity to rule out visceral recurrence with a reasonably high probability. Since the specificity of CA15-3 is pretty good, it may detect early recurrence following primary treatment of carcinoma breast.
Marketing de servicios, una perspectiva desde las competencias del personal de ventas
Authors: Campines Barría Francisco Javier
Published: August 2023

La presente investigación tiene com propósito realizar un diagnóstico de las competencias del personal de venta referentes al marketing de servicio que emplean. La metodología empleada tiene un enfoque mixto. La misma es de tipo descriptivo, su  diseño es  no experimental. Se utilizó el método de observación directa, apoyado de una lista de cotejo. La población objeto de estudio estuvo conformada por 20 vendedores de 20 empresas ubicadas en el distrito de Santiago, provincia de Veraguas. De acuerdo a los resultados percibidos y apreciados en la lista de cotejo el 75%  del personal de ventas presentan una vestimenta adecuada, el  80% demostró cortesía, el 60% proactividad y el 90% no sonríe.
Componentes de WhatsApp Business y su utilización para estrategias de marketing efectivas
Authors: Campines Barría Francisco Javier
Published: August 2023

La presenta investigación tiene por objetivo evaluar los diversos componentes que ofrece WhatsApp Business para adecuadas estrategias de marketing empresarial.  La misma tiene un enfoque de índole cualitativo, de tipo descriptiva. Los resultados destacan que dentro de la opción de perfil de empresa, la empresa debe añadir en primera instancia dentro de su foto de perfil ya sea el logotipo, isotipo, imagotipo o isólogo que lo distingue como marca empresarial y el cliente tenga noción en base a lo que observa cual es el producto o servicio que se esta ofreciendo. De igual forma esta aplicación cuenta con la opción de catálogo con la lista de los productos o servicios que la empresa ofrece. En esta se pueden añadir imágenes de los artículos, con su nombre, alguna descripción que caracterice al mismo, esto permite al cliente poder visualizar la gama de productos o servicios que esta ofrece e inclusive añadir a un carrito los productos que sean del interés de compra del cliente.  Se puede incluir la función de mensajería instantanea permite al empresario configurar las opciones de mensaje, automatizando y personalizando las mismas, para ofrecer una atención más eficiente a los prospectos que se ponga en contacto.
Credit Risk Analysis With Extreme Gradient Boosting and Adaptive Boosting Algorithm
Authors: Mendrofa Rosa Delima , Siallagan Maria Hosianna , Amalia Junita , Pakpahan Diana Pebrianty
Published: August 2023

Credit Risk Analysis digunakan untuk mengenali resiko terhadap pinjaman untuk mencegah penunggakan pembayaran utang. Pemberian uji kelayakan pinjaman dapat di analisis menggunakan model klasifikasi. Untuk menghasilkan model credit risk analysis yang sesuai, penulis mengajukan Algoritma Extreme Gradient Boosting (XGBoost) dan Adaptive Boosting (AdaBoost). Data yang digunakan dalam penelitian ini adalah data pinjaman platform Peer to Peer (P2P) Lending. Penelitian ini menerapkan data preprocessing yang bertujuan untuk menghasilkan data yang lebih baik dan melakukan analisis terhadap data. Analisis dilakukan berdasarkan fitur yang dimiliki oleh peminjam menggunakan algoritma klasifikasi berdasarkan historical data pinjaman peminjam. Fitur yang digunakan seperti jumlah pinjaman yang diajukan, total pinjaman yang ditawarkan, jumlah pembayaran pinjaman, jangka waktu pembayaran, suku bungan pinjaman, jumlah angsuran dan lain lain. Jumlah fitur sebelum dilakukan data reduksi 136 dan setelah direduksi 34 fitur.  Fitur tersebut digunakan pada penerapan algoritma XGBoost dan AdaBoost untuk menghasilkan klasifikasi good borrower dan bad borrower. Penulis menggunakan metode evaluasi kurva ROC dan nilai AUC untuk menilai performa dari kedua algoritma. Pada kurva ROC, nilai AUC dari algoritma XGBoost 0,92 dan nilai AUC dari algrithma AdaBoost adalah 0,89. Berdasarkan perbandingan nilai AUC tersebut dapat disimpulkan algoritma XGBoost menghasilkan klasifikasi yang lebih baik untuk model klasifikasi pemberian pinjaman.
ISO/IEC 25010 : Analisis Kualitas Sistem E-learning sebagai Media Pembelajaran Online
Authors: Ratnaduhita Nadiah , Sudianto Yupit , Kusumawati Aris
Published: August 2023

Pandemi COVID-19 berpengaruh pada sektor pendidikan, sehingga terjadi perubahan pada sistem pembelajaran yaitu dari tatap muka menjadi daring (online). Institusi PQR merupakan perguruan tinggi yang menggunakan e-learning sejak adanya pandemi COVID-19 untuk memudahkan aktivitas pembelajaran hingga sekarang. Sistem e-learning dapat membantu tenaga pendidik untuk merencanakan, mengelola, menyampaikan, dan melacak proses pembelajaran serta pengajaran. Melihat peran e-learning yang sangat potensial di bidang pendidikan, maka e-learning sebaiknya memenuhi kriteria kualitas suatu perangkat lunak. Sebagaimana kualitas perangkat lunak yang baik dapat merepresentasikan kesuksesan dari implementasi perangkat lunak. Maka dari itu kualitas perangkat lunak harus selalu dijaga supaya memenuhi kebutuhan pengguna dan dapat meningkatkan kualitas pendidikan di Institut PQR. Untuk mengetahui kualitas sistem e-learning sebagai media pembelajaran online, peneliti melakukan analisis terhadap kualitas sistem e-learning menggunakan ISO/IEC 25010 yang berfokus pada dimensi Software Product Quality. Kemudian peneliti menggunakan metode kuantitatif yang didukung dengan teknik analisis statistik deskriptif untuk merepresentasikan kondisi kualitas sistem menurut pengguna. Hasil penelitian menyatakan bahwa kualitas sistem e-learning Institut PQR sudah memenuhi standar ISO/IEC 25010 yaitu dengan rata-rata persentase sebesar 73,85%. Kualitas sistem dengan persentase tertinggi terdapat pada karakteristik Portability dengan persentase sebesar 82,75% dan persentase paling rendah terdapat pada karakteristik Security dengan persentase 68,11%. Meskipun demikian, terdapat beberapa subkarakteristik yang memerlukan perbaikan, diantaranya pada subkarakteristik Functional Appropriateness, Time Behavior, User Interface Aesthetics, Maturity, Non-repudiation, Modularity, dan Analysability.
Магнитная самоизоляция в сильноточных плазмодинамических системах
Authors: Loginov S. V.
Published: August 2023

В рамках одножидкостной модели плазмы выполнен анализ физических процессов в сильноточных плазмодинамических системах. Он уточняет, углубляет и разделяет различные концепции о происходящих процессах. В итоге получено непротиворечивое описание динамики плазмы любой плотности под действием быстронарастающего магнитного поля. Доказано, что основным явлением в таких системах является замагничивание и последующий дрейф электронов поперёк сильного магнитного поля. Основное внимание уделено рассмотрению плазменных прерывателей тока — систем с аксиальной симметрией. В результате проблематика прерывателей обретает единообразный подход для выявления закономерностей протекания и обрыва тока. В заключительной части монографии анализируются осесимметричные сильноточные устройства типа плазмонаполненного диода и Z-пинча.
Stomach Position as a Prognostic Marker in Fetuses with Congenital Diaphragmatic Hernia
Authors: ÖZTÜRK Merve , TANACAN Atakan , AĞAOĞLU Zahid , ÇALIŞKAN ŞENAY Zümrüt , KARA Özgür , SAHİN Dilek
Published: August 2023

Aim: To examine the relationship between stomach position and neonatal survival in congenital diaphragmatic hernia (CDH).

Materials and Method: A total of 36 pregnant women with a diagnosis of fetal CDH, aged between 18-45 years and 22-39 weeks of gestation, who applied Ankara City Hospital Perinatology clinic between December 2019 and December 2022, were analyzed retrospectively. Pregnancies were classified into two categories based on neonatal survival. Demographic characteristics, clinical features and contralateral lung size/head circumference (LHR) ratio, stomach position, and other prognostic indicators were evaluated among the survivor (n=8) and non-survivor (n=22) groups.

Results: The mean maternal age was 29.30 ± 1.02 (range 17-40), and 36% (13/36) of the patients were primigravid. The median gestational week at diagnosis was 25.10 (13.5-37.6). There was no statistically significant difference between the survivor and non-survivor groups in terms of CDH type, liver position, gestational week at diagnosis, and median LHR. Grade 2 stomach position was found to be statistically significantly higher in the survivor group (p=0.01). Operation rate and 1st-5th minute Apgar scores were higher than in the non-survivor group (p=0.02, p=0.01, and p=0.00, respectively).

Conclusion: Stomach position grading in CDH is a practical and applicable method associated with neonatal survival, and grade 2 stomach position may be a marker associated with increased survival in fetuses with CDH regardless of LHR. It may be useful in assessing neonatal prognosis and planning perinatal management, such as maternal transfer to a tertiary center where fetal interventions are available.
Les tiers-lieux en France : quelle place pour les zones hors métropole ?
Authors: Baudelle Guy , Bourdin Sébastien , Buron Louis-Thibault , Marinos Clément
Published: August 2023

L’article vise à expliquer la concentration relative des tiers-lieux par zone d’emploi (ZE) sur le territoire français. La recherche internationale s’est focalisée sur les métropoles alors que la cartographie montre que les tiers-lieux y pèsent relativement moins qu’ailleurs. On formule l’hypothèse que les tiers-lieux sont proportionnellement plus nombreux dans les ZE en difficulté économique et/ou enclavées où ils répondent aux besoins spécifiques de nouveaux travailleurs indépendants. Nous réalisons une analyse typologique afin de mettre en évidence dans quelle mesure les caractéristiques territoriales expliquent la localisation des tiers-lieux. Nous montrons que les tiers-lieux ne sont pas exclusivement un phénomène métropolitain et mettons en évidence l’existence de plusieurs France, qu’on interprète à partir d’héritages historiques de longue durée dans une perspective théorique évolutionniste.
Facteurs et modalités d’insertion des activités productives entre tissus urbains et parcs d’activité économique
Authors: Gilbart Alexis , Mazy Kristel
Published: August 2023

À la croisée des enjeux de réindustrialisation et de sobriété foncière, cet article questionne les pratiques d’aménagement économique par le prisme des facteurs et modalités d’insertion des activités productives au sein des tissus urbains et des parcs d’activité économique. Comment une volonté régionale de réindustrialisation se traduit-elle localement ? Si la question de la réindustrialisation dans les villes petites et moyennes est indissociable d’une meilleure compréhension de l’écosystème entrepreneurial local, d’une part, et d’une meilleure intégration de la fonction productive dans les politiques d’aménagement urbain, d’autre part, quelles sont les dynamiques relationnelles qu’entretiennent la production et le territoire ? Cette étude, réalisée sur les territoires post-miniers de Mons-Borinage, localisés en Belgique, aborde ces questionnements en trois temps : d’abord par la mise en contexte du territoire ; ensuite par la mise en lumière d’une étude empirique menée auprès de 10 TPE-PE productives, abordée par le prisme de l’entrepreneur ; et enfin par la mise en perspective de ces résultats en confrontant les pratiques d’aménagement économique aux objectifs de sobriété foncière.
Paınless Legs and Movıng Toes: Idıopathıc or Not?
Authors: Üçgül Elif E. , Zengin Sergül , Özşahin Aygün , Domaç Füsun M.
Published: August 2023

Painless legs and moving toes (PoLMT) is a rare variant of painful legs and moving toes (PLMT). The difference is the absence of pain, which is usually hard to manage in PLMT. An involuntary movement in the toes is a compound of both. Although there are many medication options for this disease, most fail to treat it successfully. Here, we report on a 62-year-old female with involuntary movements in her toes for five years. The rarity and unclear etiology of the disease are the reasons we wanted to present it.
A Pictorial Essay of Somatostatin Receptor Imaging in Tumor-Induced Osteomalacia
Authors: Luthra Karuna , Gauthaman Dinesh Kumar , Lele Vikram
Published: August 2023

Tumor-induced osteomalacia (TIO) is a rare cause of severe debilitating osteomalacia, due to hypophosphatemia. A strong clinical suspicion based on biochemical parameters can lead to the search for a culprit tumor in the body. The disease entity is more commonly caused by benign mesenchymal tumors. While many imaging modalities have been tried, it is now known that these tumors show high somatostatin receptor (SSTR) expression. Hence SSTR receptor imaging has emerged as a useful diagnostic tool. Here we present a series of TIO cases with clinical presentation and imaging characteristics.
Role of 99mTc-Methylene Diphosphonate Bone Scintigraphy in the Evaluation of the Viability and the Incorporation of the Bone Allograft Used in Orthopedic Reconstruction
Authors: Meena Anjali , Veerwal Hardik , Dhingra Vandana Kumar , Dhingra Mohit
Published: August 2023

Allogenic bone is the most commonly grafted tissue which provides only osteoconductive property, in which it acts as a scaffold to facilitate the ingrowth of the vessels and migration of host cells capable of osteogenesis. It can be used as a substitute for autografts as the latter is associated with morbidity and limited donor site availability. Its applications are expanding in all aspects of orthopedic surgery, notably in revision hip replacement or surgical treatment for bone tumors or benign conditions. The balance between osteolysis and osteogenesis must be maintained for graft incorporation to occur and thus postoperative imaging is essential for differentiation between grafts and recurrent disease or viability/nonviability. Here, we present three cases, in which bone allografting was done who underwent serial 99 mTc-methylene diphosphonate three-phase bone scintigraphy with single-photon emission computed tomography/computed tomography to assess the viability, integrity, and the incorporation of the graft.
Assessment of Treatment Response by Bone SPECT-CT in a Case of Dermatomyositis with Calcinosis Cutis
Authors: Patro P. Sai Sradha , Patra Subhabrata , Kumar Rajesh , Agrawal Kanhaiyalal , Parida Girish Kumar
Published: August 2023

Calcinosis of soft tissue is a rare but known complication of dermatomyositis (DM), mostly associated with juvenile DM and rare in adult DM. Bone scan with Tc-99m Methylene diphosphonate is useful in disease mapping and has high sensitivity to know the extent of calcinosis. However, there is scanty literature available on the utility of bone scan in treatment response evaluation in DM. Rituximab has been found useful in adult DM with calcinosis unresponsive to conventional treatment. We describe an interesting case showing partial response to rituximab on bone scan with single-photon emission tomography-computed tomography.
Design and Evaluation of MeVisLab Networks for Co-Registration and Cropping of Positron Emission Tomography/Computed Tomography Scans
Authors: Pandey Anil Kumar , Sharma Akshima , Kumar Sunil , Negi Ashish , Singh Satnam , Kumar Sanjay , Kumar Rakesh
Published: August 2023

Objective:

The aim of the present study was to design and evaluate two MeVisLab networks, one for co-registration of positron emission tomography/computed tomography (PET/CT) images and second for cropping the co-registered PET/CT images.

Materials and Methods:

Two MeVisLab networks, one to co-register and export PET/CT DICOM images and second for cropping the co-registered PET/CT images were designed using different modules of registration toolkit MERIT. One hundred and twenty-five PET/CT studies were exported from Siemens and GE scanners in DICOM format. These images were co-registered and cropped with our designed networks. The images co-registered with our network were compared visually with the co-registered images of same PET/CT studies on vendor provided workstations by an experienced nuclear medicine physician (NMP). The perfection of the cropping of co-registered images was also assessed visually.

Results:

Visually, NMP found all 125 images co-registered using the network designed in our study similar to the co-registered images of vendor provided workstations. Furthermore, the cropping of all co-registered images was perfectly done by our network.

Conclusion:

Two MeVisLab networks designed and evaluated in the present study can be used for co-registration of PET/CT DICOM images and cropping the co-registered PET/CT images.
Lewy Body Dementia Associated with Anti-IgLON 5 Encephalitis Detected on 18F Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and 99mTc-TRODAT Single-Photon Emission Computed Tomography/Computed Tomography
Authors: Seniaray Nikhil , Verma Ritu , Ranjan Rajeev , Belho Ethel , Mahajan Harsh
Published: August 2023

We present a case of Anti-IgLON 5 encephalitis with Lewy body dementia. 18F fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan and 99 mTc-TRODAT-1 SPECT/CT scan were done. 99 mTc-TRODAT-1 scan findings revealed severely reduced concentration of dopamine transporter in bilateral basal ganglia, suggestive of a degenerative parkinsonian disorder. 18F-FDG PET scan findings were suggestive of moderate-to-severe hypometabolism in the bilateral parieto-temporal and bilateral occipital cortices including the primary visual cortices, supporting Lewy body spectrum disease with associated hypermetabolism in the bilateral sensorimotor cortices, bilateral basal ganglia, thalami, brain stem, and bilateral cerebellar hemispheres suggestive of inflammatory pathology.
Role of Ga-68 DOTANOC Positron Emission Tomography/ Computed Tomography Scan in Clinical Management of Patients with Neuroendocrine Tumors and its Correlation with Conventional Imaging- Experience in a Tertiary Care Center in India
Authors: Singh Deepa , Arya Amitabh , Agarwal Amit , Agarwal Gaurav , Ravina Mudalsha , Gambhir Sanjay
Published: August 2023

Purpose of Study:

Aim of the study was to evaluate the role of 68Gallium-DOTANOC positron emission tomography/computed tomography (68Ga-DOTANOC PET/CT), a pan somatostatin receptor (SSTR) analog in the clinical management of patients with neuroendocrine tumors (NETs) and its correlation with conventional imaging.

Materials and Methods:

We retrospectively evaluated 69 patients of known/suspected NETs who underwent 68Ga-DOTANOC PET/CT scan for tumor localization (n = 15), stage modification (primary staging, n = 26 and restaging, n = 25) and therapy monitoring (n = 3). We also compared PET scan with conventional imaging as reference standard and evaluated the impact of PET/CT in the clinical management of patients.

Results:

The concordant findings on 68Ga-DOTANOC PET/CT and conventional imaging seen in 33 and discordant in 36 patients. Among discordant group, disease was upstaged in 32 patients; down staged in 3 patients; no stage change in one patient. PET/CT localized primary tumor in 4 patients. Among patients with raised tumor markers (39/69), PET was positive in 29 and negative in 10 patients. Patients were followed for mean duration of 27 months to assess management. We found strong agreement between positive PET and raised tumor markers (Kappa value = 0.8). Sensitivity and specificity of PET/CT for primary tumor localization, stage modification, and therapy monitoring was >90% (P < 0.05).

Conclusions:

Study shows that DOTANOC, a broad spectrum SSTRs binding peptide labeled with Ga-68 in PET/CT scan is an excellent modality in the management of NETs patients.
Global and Regional Gastric Emptying Parameters
Authors: Saifi Tabassum , Singhal Abhinav , Gupta Priyanka , Chandra Khangembam Bangkim , Pandey Anil Kumar , Patel Chetan , Kumar Rakesh
Published: August 2023

Purpose of the Study:

The purpose of the study is to establish the reference values of global and regional gastric emptying parameters (GEPs) using a standard vegetarian meal acceptable to the Indian population and compare the values derived on different camera view methods.

Materials and Methods:

Thirty-six consecutive healthy subjects with age ≥18 years underwent gastric emptying scintigraphy using anterior, posterior, and left anterior oblique (LAO) views. GEP was derived based on decay corrected counts in regions of interest defined on the whole and proximal stomach. Counts in the anterior and posterior view images were used to derive GEP based on geometric mean (GM) method. Comparison of GEP among different camera view methods was done with Friedman test and post hoc Wilcoxon signed-rank test after Bonferroni correction. Reference values were derived based on percentiles.

Results:

Rapid gastric emptying based on GM method was defined as percent retention <20% at 1 h while delayed emptying as percent retention >40% and >5% at 2 h and 4 h, respectively. The reference range of half-time of gastric emptying was 23–109 min. The reference value of intragastric meal distribution at time t = 0 was >64%, while the reference range of retention index was 0.7–1.3. Although the overall distribution of GEP derived on different camera view methods could be statistically significant (P < 1.00), the small differences in the derived reference values are likely to be of no clinical significance.

Conclusion:

The reference values of GEPs established in this study can be generalized for the Indian population and may be applied to aid in clinical decision making. We recommend the GM method as the preferred method, although single view method (LAO preferred over anterior) can also be an acceptable alternative.
Quality Assessment of Tc-99m Methylene Diphosphonate (MDP) Radiopharmaceutical Prepared Using Different Cold Kit Fractionation Methods
Authors: Thokchom Arun Kumar , Kumar Rajesh , Bharati Sanjay , Vasumathi
Published: August 2023

Purpose:

Tc-99m Methylene diphosphonate (MDP) is prepared in house by labeling MDP cold kit. Each kit is a single time use vial and contains large amounts of reagent sufficient for preparing multiple doses. Therefore, several centers are adopting the practice of fractionating the MDP kit so that it can be used multiple times. The aim of the study was to evaluate the effect of kit fractionation on radiopharmaceutical property.

Materials and Methods:

The MDP kit was fractionated using two different approaches, namely, vial and syringe method. The quality of Tc-99m MDP prepared using these approaches was assessed and compared with that prepared by the conventional method. The image quality was evaluated in a total of 100 patients.

Results:

The vial and syringe fractionated Tc-99m MDP showed >95% RCP till the 4th and 2nd days of fractionation, respectively. Percentage radiochemical purity deteriorated to 83.6% and 88% on the 8th day of fractionation in the vial and syringe method, respectively. No microbial growth was observed in any of these methods till the 8th day of fractionation. The reconstituted MDP solution during all preparations was clear and colorless in appearance with pH ranging from 6.5 to 7.5. The image contrast, contrast-to-noise, and signal-to-noise ratio were statistically similar in both methods compared to the conventional method until the 2nd day of fractionation. The image quality data showed no statistical difference among images of vial and syringe fractionated MDP as compared to the conventional unfractionated Tc-99m MDP.

Conclusions:

The observations revealed that if fractionated with utmost care, both methods yield almost similar results.
Unexpected Metastasis to Breast, Lymph Node, Subcutaneous, Abdominal Wall, Intraabdominal, and Bone in Osteogenic Osteosarcoma
Authors: Meena Anjali , Veerwal Hardik , Dhingra Vandana K , Dhingra Mohit
Published: August 2023

Osteogenic osteosarcoma is an aggressive malignant bone tumor with the tendency for local invasion and early metastases. Radionuclide bone scans play an important role in disease management by identifying other areas of skeletal involvement as well as extraosseous metastases. Osteogenic sarcoma metastasis is known to accumulate bone-avid agents due to their osteogenic potential. Here, we report a case of osteogenic osteosarcoma of distal femur with the absence of pleural effusion but extensive extraosseous areas of metastatic involvement in distant lymph nodes, subcutaneous planes (in the form of nodules), abdominal wall, multiple intraperitoneal deposits, breast, and bone metastases visualized on preoperative Tc-99 m methylene diphosphonate bone scan.
Metastatic Urinary Bladder Carcinoma on Palliative Chemotherapy Showing Rapid Progression on Interim Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography
Authors: Saini Vivek Kumar , Mammoottil Alen Elias , Hassan Aftab Nazar , Ora Manish , Gambhir Sanjay
Published: August 2023

Bladder cancer (BC) is among the top ten most common cancer types globally. Muscle invasive BC has a high incidence of metastasis. Metastatic BC has a poor prognosis and limited treatment options. Here, we present a middle-aged man with oligometastatic BC, which was treated with palliative chemotherapy. He had significant clinical improvement. However, interim 18F-Fluorodeoxyglucose positron emission tomography/computed tomography demonstrates a rapid disease progression extensive metastasis.
Angiogenesis versus Metabolic Imaging in Locally Advanced Breast Cancer Patients – A Comparative Study
Authors: Kumar Sunil , Vatsa Rakhee , Shukla Jaya , Singh Gurpreet , Bal Amanjit , Mittal Bhagwant Rai
Published: August 2023

Purpose:

The comparison of angiogenesis imaging (Ga-68-DOTA-Arginine-Glycine-Aspartic Acid [RGD]) positron emission tomography/computed tomography [PET/CT]) with metabolic imaging (F-18 fluorodeoxyglucose [FDG] PET/CT) in primary staging and response assessment to neoadjuvant chemotherapy (NACT) in locally advanced breast cancer (LABC) patients.

Methods:

In this prospective study, 85 female patients with LABC were subjected to two PET/CT studies (Ga-68-DOTA-RGD2 and F-18 FDG) within 1 week of each other. Thirty patients had repeat studies 4 weeks after completing eight cycles of NACT. Response assessment was done by RECIST 1.1 criteria.

Results:

Ga-68-DOTA-RGD2 and F-18 FDG uptake in the primary tumor were seen in all patients. Ipsilateral axillary and internal mammary lymph nodes were detected in 77 (90.5%) versus 80 (94.1%) and 22 (25.8%) versus 27 (31.7%) patients on Ga-68-DOTA-RGD2 and F-18 FDG scans, respectively. Ipsilateral supra-clavicular lymph nodes and skeletal lesions were noted in 17 (20%) versus 21 (24.7%) patients and 23 (27.0%) versus 24 (28.2%) patients on Ga-68-DOTA-RGD2 versus F-18 FDG studies, respectively. However, the Ga-68-DOTA-RGD2 did not show uptake in F-18 FDG avid liver lesions (LLs) in 10 patients, adrenal lesion in one patient, mediastinal lymph nodes in 2 patients, lung nodules, and pleural soft-tissue deposits, each in one patient. In response assessment, 23 and 25 patients had concordance with RECIST1.1 criteria on F-18 FDG and Ga-68-DOTA-RGD2 scans, respectively. However, there were discordant results in four patients on Ga-68-DOTA-RGD2 scan and two patients on F-18 FDG scans.

Conclusion:

Metabolic imaging is better in primary staging and chemotherapy response assessment than angiogenesis imaging in LABC patients. The latter may miss the metastatic soft-tissue deposits, adrenal, and LLs.
18F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography and Computed Tomography in a Large Pulmonary Sclerosing Pneumocytoma with Contralateral Lung Metastasis
Authors: Ganga Ranganath Thippanahalli , Ravina Mudalsha , Sahu Dibakar , Gupta Rakesh Kumar , Pati Saroj Kumar
Published: August 2023

Pulmonary sclerosing pneumocytoma is an exceedingly rare neoplasm of the lung. These tumors are usually slow growing with a benign disease course but can easily be mistaken for carcinoid tumors or adenocarcinoma in cytology or histopathology specimens. Rare occurrences of metastases have been reported in the literature making 18F-labeled fluoro-2-deoxyglucose positron emission tomography and computed tomography useful for the evaluation of these tumors.
Fully Automated Synthesis of Nitrogen-13-NH3 by SHIs HM-18 Cyclotron and Dedicated Module for Routine Clinical Studies
Authors: Akhilesh Singh K. , Shanker Nilesh , Subhash Kheruka C , Sanjay Gambhir , Dixit Manish
Published: August 2023

Aims:

The production of nitrogen-13 (13N)-NH3 by ethanol method using automated synthesizer and accessing the production yield, quality control for clinical application.

Context:

13N, together with 18F, 15O, and 11C, is one of the positron emitters that can be produced on the multi-gigabecquerel scale in biomedical cyclotrons. (13N)-ammonia is frequently used for cardiac PET studies. It is widely applied for the evaluation of myocardial perfusion in the clinical assessment of cardiac disorders. Simple, fast, and reliable preparation methods have contributed to the routine application of this tracer. Although only two methods are available, a challenge remains to adopt a more efficient and consistent approach to its production. For clinical application, routine production of this tracer is mandatory in compliance with regulatory guidelines. Being at hospital radiopharmacy it is our responsibility to support the clinical service with uninterrupted production and supply of (13N)-NH3.

Materials and Methods:

The chemicals were used commercially available from Sigma Aldrich, India, Ltd., and Fisher Scientific, India, Ltd. (Mumbai, India), Sep-Pak CM cartridges (Waters India, Pvt., Ltd.,). Radio-thin layer chromatography was carried out using aluminum sheets precoated with silica gel 60 F254 (E. Merck, India).

Results:

The protocol developed with MPS-100 synthesizer yield (13N)-NH395–97% (EOB) with a synthesis time of around 7 min.

Conclusions:

With the installation of HM-18 cyclotron at our hospital, center is capable to produce (13N)-NH3 of good yield and purity through the ethanol method, for mycocardial perfusion studies. Our protocol is simple, reproducible, and robust.