bluuebunny/crossref_metadata_2025 huggingface dataset:
Compatible Ferroelectricity, Antiferroelectricity and Broadband Emission for a Multi-Functional 2D Organic-Inorganic Hybrid Perovskite
Authors: Wei Wenjuan , Gao Hongqiang , Tan Yuhui , Tang Yunzhi
Published: February 2021

Two-dimensional (2D) organic-inorganic hybrid perovskites with multifunctional characteristics have potential applications in many fields, such as, solar cells, microlasers and light-emitting diodes (LEDs), etc. Here, a 2D organic-inorganic lead halide perovskite, [Br(CH2)3NH3]2PbBr4 (BPA-PbBr4, BPA = Br(CH2)3NH3, 3-Bromopropylamine), is examined for its photophysical properties. Interestingly, BPA-PbBr4 reveals five successive phase transitions with decreasing temperature, including successive paraelectric-ferroelectric-antiferroelectric phases. Besides, BPA-PbBr4 displays ferroelectricity and antiferroelectricity throughout a wide temperature range (<376.4 K) with accompanying saturation polrization (Ps) values of 4.35 and 2.32 μC/cm2, respectively, and energy storage efficiency of 28.2%, and also exhibits superior second harmonic generation (SHG) with maximum value accounts for 95 % of the standard KDP due to the great deformation of structure (3.2302*10-4). In addition, the photoluminescence (PL) of the BPA-PbBr4 exhibits abnormal red-shift and blue-shift in different phases due to a consequence of competition between electron-phonon interaction and the lattice expansion. Further, BPA-PbBr4 reveals a broadband emission accompanied by bright white light at room temperature (293 K), which is supposed to be due to self-trapped excitons. In short, the versatility of BPA-PbBr4 originates from molecular reorientation of dynamic organic cations, as well as significant structural distortion of PbBr6 octahedra. This work paves an avenue to design new hybrid multifunctional perovskites for potential applications in the photoelectronic field.
Rational Engineering of a Carboxylesterase for the Synthesis of Polyesters for Biomedical Applications
Authors: Almeida Beatriz , Figueiredo Pedro , Dourado Daniel F.A.R. , Paul Stephanie , Quinn Derek J. , Moody Thomas S. , Sousa Andreia F. , Silvestre Armando J.D. , Carvalho Alexandra
Published: February 2021

Reengineered variants of a hyperthermophilic carboxylesterase with improved product yield in the synthesis of poly(ε-caprolactone) and triblock poly(ε-caprolactone)-co-poly(ethylene glycol)

Methods: Quantum Mechanics/Molecular Mechanics Molecular Dynamics simulations, enzyme expression, enzymatic assays and characterization of the products.
Rational Design and Synthesis of Novel Dual Protacs for Simultaneous Degradation of EGFR and PARP
Authors: Zheng Mengzhu , Huo Junfeng , Gu Xiaoxia , Wu Canrong , Zhang Qingzhe , Wang Wang , Liu Yang , Liu Yu , Zhou Xuechen , Chen Lixia , Zhou Yirong , Li Hua
Published: February 2021

Inspired by the success of dual targeting drugs, especially bispecific antibodies, we propose to combine the concept of protac and dual targeting to design and synthesize dual protac molecules with the function of degrading two completely different types of targets simultaneously. A library of novel dual targeting protac molecules have been rationally designed and prepared. A convergent synthetic strategy has been utilized to achieve high synthetic efficiency. These dual protac structures are characterized by using trifunctional natural amino acids as star-type core linkers to connect two independent inhibitors and E3 ligands together. In this study, gefitinib, olaparib, and CRBN or VHL E3 ligand were used as substrates to synthesize novel dual protacs. They successfully degraded both EGFR and PARP simultaneously in cancer cells. Being the first successful example of dual protacs, this technique will greatly widen the range of application of the protac method and open up a new field for drug discovery.
The Role of Hydrogen Bonding in the Dehydration of Bioalcohols in Hydrophobic Pervaporation Membranes
Authors: Madero-Castro Rafael M. , Calero Sofía , Yazaydin A. Ozgur
Published: February 2021

The dehydration of bioalcohols is considered one of the major factors contributing to the cost of biofuel production. In this study, liquid phase separation of water from methanol and ethanol in a siliceous MFI pervaporation membrane was studied by performing concentration gradient driven molecular dynamic (CGD-MD) simulations. CGD-MD simulations work by imposing a higher concentration in the feed side and a lower concentration in the permeate side of the membrane. This creates a concentration gradient across the membrane that facilitates the diffusion of molecules from the feed to the permeate side, mimicking the experimental pervaporation membrane set up. Fluxes of methanol, ethanol and water were calculated in single component permeation simulations and in equimolar methanol-water and ethanol-water mixture separation simulations. It was found that water formed hydrogen bonding with the silanol (Si-OH) groups on the external surface of the MFI and did not enter the membrane in the single component permeation simulation. While this may suggest that MFI can be used to effectively dehydrate bioalcohols, our simulations showed that water permeated through the MFI membrane when it was in a mixture with either methanol or ethanol. Furthermore, in the alcohol-water mixture simulations, the fluxes of methanol and ethanol were significantly lower than that of expected based on their single component fluxes. A detailed analysis of hydrogen bonding in the alcohol-water mixture separation simulations revealed that water preferred making hydrogen bonds with methanol and ethanol rather than with the silanol groups. This resulted in drifting of water molecules along with permeating alcohol molecules in to the MFI membrane in mixture simulations, while slowing the permeation of methanol and ethanol fluxes.
Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation
Authors: Feng Minghao , De Oliveira Joao , Sallustrau Antoine , Destro Gianluca , Thuéry Pierre , Roy Sebastien , Cantat Thibault , Elmore Charles S. , Blankenstein Jörg , Taran Frédéric , Audisio Davide
Published: February 2021

The incorporation of carbon-14 allows tracking of organic molecules and provides vital knowledge on their fate. This information is critical in pharmaceutical development, crop science and human food safety evaluation. Herein, a transition-metal-catalyzed procedure enabling carbon isotope exchange on aromatic nitriles is described. Utilizing the radiolabeled precursor Zn([14C]CN)2, this protocol allows the insertion of the desired carbon tag without need of structural modifications, in a single step. Reducing synthetic costs and limiting the generation of radioactive waste, this procedure will facilitate the labeling of nitrile containing drugs and accelerate 14C-based ADME studies supporting drug development.
Differential diagnosis and treatment of primary peritoneal cancer and mesothelioma
Authors: Abdullaev Amir G. , Kozlov Nikolay A. , Schakhpazyan Nikolay K. , Tsigankova Anna V.
Published: February 2021

Primary peritoneal cancer and mesothelioma belong to one nosological structure namely primary malignant neoplasms of the peritoneum. Such pathologies, regardless of their morphological differences, have the following in common: low incidence, the absence of pathognomonic signs, similarity of radiological signs and lack of knowledge regarding prognostic factors. Considering the low incidence, reliable differential diagnostic indicators are not currently set up, which makes it substantially more complicated to timely formulate the diagnosis. On the contrary, more often we could reveal the cases where the wrong treatment strategy has been chosen, the absence of unified maintenance algorithm, when in fact a history of a patient`s present illness represents an individual creation of a particular doctor. On the other hand, the independent experience of a number of clinics does not exceed a few observations, which does not allow doctors to confidently navigate the problem. Thus, the relevance of conducting multicenter and perhaps prospective randomized scientific research studies with the aim of unified algorithm elaboration of the management of patients with primary peritoneal neoplasms has become imminent. The traditional algorithms for this pathology treatment embrace surgical step and systemic or intracavitary chemotherapy, where treatment sequence could be varied and foremost depends on a disease spread. In order to determine the extent of intraperitoneal dissemination the Sugarbaker peritoneal carcinomatosis index (PCI) is currently used, it also has been proved that one of the main prognostic factors is the degree of cytoreduction completeness. In the article below, we have tried to provide modern concepts of primary peritoneal cancer and peritoneal mesothelioma diagnosis, treatment and prognosis.
Recurrent desmoid-type retroperitoneal fibromatosis: clinical observation
Authors: Budurova Marina D. , Fainshtein Igor A. , Turupaev Kirill A. , Kalinin Aleksei E. , Kozlov Nikolai A.
Published: February 2021

This article deals with the rare clinical observation of the patient with recurrent desmoid-type fibromatosis, who have achieved long-term stability after surgical treatment. A 24-year-old patient was diagnosed with retroperitoneal tumor which size was 8.85.613 cm in 2013, infiltrating the left psoas muscle, left kidney, left common and left external iliac arteries, descending colon and sigmoid colon. The patient underwent surgery in the volume of the tumor removal, resection of the left common iliac artery and prosthetics using GORE-TEX prosthesis, left hemicolectomy, left nephrectomy at Blokhin National Medical Research Center of Oncology. The first recurrence of the tumor was detected nine months after the surgery. Due to the subsequent growth of tumor mass, located along the left external iliac artery and in the inguinal canal, the repeated surgery was performed. Then the patient had a second relapse, and underwent surgery again. The third recurrence was detected seven months after the last surgery. During the multidisciplinary discussion, according to the absence of complaints and the small size of the recurrent tumor, as well as the absence of the risk of life-threatening complications, it was decided to stop on the observation. The patient was examined once every six months there were no data concerning recurrent tumor growth. Today, the patient is alive, does not have any complaints and is able-bodied. Our clinical observation demonstrates that active surgical tactics in case of the retroperitoneal fibromatosis recurrence not always can lead to long-term progression-free survival time and several patients can stay under the observation, using Look and Stay tactic.
Radiation therapy in treatment of Rosai–Dorfman disease: literature review and report of a patient with cutaneous form
Authors: Potapenko Vsevolod G. , Belousova Irena E. , Vinogradova Julia N. , Kelehsaeva Karina A. , Ulitin Andrey M. , Smirnova Irina O. , Petunova Yanina G. , Ilyin Nikolay V.
Published: February 2021

RosaiDorfman disease (RDD) is a rare variant of the nonlangergans histiocytosis. Various presentation, systemic and localised forms and limited publications make diagnostics and prompt management difficult. Aim. Literature review and presentation of the patient with cutaneous form of RDD. Results. The patient is a 56 y.o male. In October 2019 he noticed a tumour in the left temporal area. After 3 weeks the tumor was removed. During the next two weeks the tumour recurred within the post-operative scar. After the review of the specimen and staging the skin form RosaiDorfman disease was diagnosed. Irradiation (total dose 36 Gr) was conducted. The tumor lessened. Through the next 4 months response is stable. Сonclusion. Radiation therapy as a second line of treatment of the skin RDD led to a stable response.
The consensus on the prevention and correction of hyperglycemia in patients with HR+ HER2- metastatic breast cancer treated with alpelisib
Authors: Mazurina Natalya V. , Artamonova Elena V. , Beloyartseva Maria F. , Volkova Ekaterina I. , Ganshina Inna P. , Troshina Ekaterina A. , Tjulandin Sergey A. , Chubenko Viacheslav A.
Published: February 2021

The consensus on the prevention and correction of hyperglycemia in patients with HR+ HER2- metastatic breast cancer treated with alpelisib was developed by the experts of the Russian Association of Endocrinologists and the Russian Society of Clinical Oncology. The consensus contains recommendation on risk assessment, prophylaxis and correction of hyperglycemia regarding the baseline metabolic status of the patients.
A real way of reducing coronary heart disease mortality in Russia
Authors: Aronov D. M , Bubnova M. G
Published: February 2021

The paper analyzes reasons for high cardiovascular mortality in Russia and states that therapeutic work done by primary practitioners is ineffective. It gives the statistical data of the European Union, the USA, and some other countries where overmortality from cardiovascular diseases has been overcome by the governmental cardiovascular prevention and rehabilitation system. It is concluded that the experience of these countries can be applied to reduce cardiovascular overmortality in Russia
Meditsinskiy aspekt reabilitatsii bol'nykhishemicheskoy bolezn'yu serdtsana sanatornom etape
Authors: Shestakov Vladimir Nikolaevich , Zobenko Irina Aleksandrovna , Misyura Ol'ga Fedorovna , Perepech Nikita Borisovich
Published: February 2021

Summary. Analysis of the drug therapy in patients with myocardial infarction at sanatorium stage of rehabilitation
was performed at Health Medical Center Chernaya Rechka. Within the period from 2003 to 2009 the rate of patients
treated with drugs with proven effect on prognosis increased. Frequency of statins prescription increased from
8,3 to 95%. In majority of patients target values of blood pressure and heart rate were reached. Data on postoperative
complications in patients after aortocoronary bypass at sanatorium stage of cardiac rehabilitation is presented.
Hydrothorax and hydropericardium were revealed in 32 and 21% of all patients respectively, breath dysfunction in
40%, hypochromic anemia in 50, heart rate disorders in 27% of patients. The positive role of complex rehabilitation
in decreasing of severity of postoperative complications was confirmed.
Ostryy koronarnyy sindrom: kompleksnyypodkhod v taktike vedeniya patsientov,rol' pervichnoy i vtorichnoy profilaktiki
Authors: Skopets Inga Sergeevna , Vezikova Natal'ya Nikolaevna , Marusenko Irina Mikhaylovna , Malygin Aleksandr Nikolaevich
Published: February 2021

Summary. The article analyzes the clinical course, tactics and long-term outcomes in patients with acute coronary
syndrome treated at the Regional Vascular Center. An important aspect is not only medication and treatment tool
in the acute phase, but also an adequate primary and secondary prevention, which can contribute to improving the
quality of life for patients, reducing mortality, economic costs as well as clinical and social consequences of coronary
heart disease.
Rol' polimorfizma gena konneksina 40v geneze nasledstvennogo sindroma slabostisinusovogo uzla
Authors: Nikulina Svetlana Yur'evna , Chernova Anna Aleksandrovna , Shul'man Vladimir Abramovich , Kukushkina Tat'yana Sergeevna , Voevoda Mikhail Ivanovich , Maksimov Vladimir Nikolaevich
Published: February 2021

Summary. In this study for the first time on clinical-genetic material an association of the hereditary sick sinus
syndrome (SSS) with the connexin 40 gene polymorphism was found.
For the first time it was revealed that the heterozygous variant of connexin 40 gene genotype was significantly more
common in patients with SSS and their healthy relatives in comparison with subjects of the control group.
Hemodynamic and endothelium-protective effects of β-adrenoblockers in patients with coronary heart disease complicated by chronic heart failure and atrial fibrillation
Authors: Zakirova A. N , Abdyukova E. R , Zakirova N. E
Published: February 2021

Aim. To elucidate effect of b-adrenoblockers on remodeling of myocardium and adhesive function of endothelium in with ischemic heart disease with chronic heart failure (CHF) and addition of atrial fibrillation (AF). Material and methods. We included into the study 77 patients with functional class II–III CHF and AF of ischemic genesis randomized in 2 groups, In group 1 were included 40 patients who during 24 weeks used carvedilol at the background of basic therapy, in group 2–37 patients receiving metoprolol tartrate. In the work we used clinico-instrumental (echocardiography, test with 60 minute walk), immunoenzymatic (soluble intercellular adhesion molecules (sVCAM, SE – selectin) methods of investigation. Results. Application of both BAB improved clinical state and physical working capacity of patients with CHF and AF. Carvedilol more significantly than metoprolol tartrate prevented remodeling of myocardium, inhibited expression of cellular adhesion molecules. Levels of sE-selectin and VCAM-1 decreased under action of carvedilol. Conclusion. Carvedilol in long term therapy of CHF with AF exerts substantial influence on adhesive function of endothelium and improves hemodynamics.
Osobennosti kardioprotektivnogo deystviyazofenoprila vo vtorichnoy profilaktikeserdechno-sosudistykh zabolevaniy
Authors: Vaulin Nikolay Aleksandrovich
Published: February 2021

Summary. Zofenopril is one of the most recent ACE inhibitors; it shows a high lipophilicity. This property determines
its high and rapid absorption, a considerable proportion of excretion with bile and improved tissue permeability
associated with the prolonged effect of tissue ACE inhibition.
This property must underlie some effects of zofenopril, which are absent in other drugs of this class. Thus, the combination
of lipophilicity and antioxidant activity ensures the optimal antihypertensive efficacy along with antiatherogenic
activity.
These two latter properties most probably make a major contribution to a reduction in death rates after myocardial
infarction, as conclusively demonstrated in a series of SMILE clinical trials.
The above properties of zofenopril support once again the idea that not all ACE inhibitors are equally effective in
the treatment of arterial hypertension and in secondary prevention after myocardial infarction.
Chronic obstructive pulmonary disease and arterial hypertension: methaphysics and dialectic
Authors: Li V. V , Zadionchenko V. S , Adasheva T. V , Pavlov S. V , Shakhrai N. B
Published: February 2021

The paper provides a review of prevalence and outcomes of cardiovascular comorbidities in patients with chronic obstructive pulmonary disease (COPD). From a clinical and patient-centered perspective, a COPD phenotype should be able to classify patients into distinct subgroups that provide prognostic information and allow to better determine appropriate therapy that alters clinically meaningful outcomes. It is hypothesized that both COPD and artherial hypertension (AH) have common pathway linking these comorbidities and explaining why they significantly complicate the management and influence the prognosis of patients with COPD and AH. Further studies will be required to explore this hypothesis and understand the relationship between COPD and AH.
Predictors of cardiovascular events in patients with chronic heart disease after surgical myocardial revascularization (according to the data of a long-term observation)
Authors: Shalayev S. V , Arutyunyan L. A
Published: February 2021

Aim. To elucidate independent predictors of fatal and nonfatal cardiovascular events in patients with chronic heart disease (CHD) after surgical myocardial revascularization during a long-term prospective observation. Subjects and methods. The study enrolled 120 patients with CHD who had undergone coronary artery bypass grafting with extracorporeal circulation. Further 2-5-year follow-ups recorded deaths from cardiac causes, including sudden deaths, as well as the incidence of nonfatal cardiovascular events (myocardial infarction, stroke). Results. The mean follow-up time was 36±5 months. During the follow-ups, there were 12 deaths: 1 and 8 deaths from pneumonia and myocardial infarction, respectively; 3 patients died suddenly. Out of the nonfatal events, myocardial infarction and stroke were recorded in 7 and 2 cases, respectively. Stepwise regression analysis showed that the independent predictors of fatal cardiac events were as follows: 1) an ejection fraction of less than 40% (relative risk 5.7 with deviations within 95% confidence interval, 1,2–10,7); 2) age of 70 years or older (4,9; 1,4–8,4); 3) diabetes mellitus (2,3; 1,1–3,7); 4) left ventricular aneurysm (2,1; 1,04–3,8); 5) mechanical ventilation for more than 24 hours (2,0; 1,2–2,9); 6) chronic obstructive pulmonary disease (1,9; 1,1–3,1). The independent predictors of all cases of both fatal and nonfatal cardiovascular events were: 1) age of 70 years or older (4,1; 1,2–8,1); 2) an ejection fraction of less than 40% (3,7; 1,1–6,5); 3) endarterectomy during coronary artery bypass grafting (2,9; 1,1–5,4); 4) mechanical ventilation for more than 100 minutes (2,2; 1,2–3,9); damage to the brachiocephalic artery area (2,1; 1,1–6,4), prior stroke (1,8; 1,1–3,8). Conclusion. The conducted study indicated the implication of both the poor traditional predictors of CHD and comorbidity, as well as the specific features of surgical intervention and anesthetic maintenance in the development of further fatal and nonfatal cardiovascular events in patients with CHD after surgical myocardial revascularization.
Astenicheskiy sindrom v kardiologicheskoypraktike
Authors: Kopylov F Yu , Nikitina Yu M , Makukh E A
Published: February 2021

Summary. Asthenic syndrome often occurs in the cardiologist daily practice. Fatigue can develop not only against
the background of various cardiovascular diseases, but also be a symptom of mental disorder, which should be considered
in the diagnosis and treatment. Treatment of asthenic syndrome based on both the application of various
non-drug approaches and the use of pharmacotherapy.
Methodological issues in the organization and implementation of outpatient rehabilitation exercise programs in patients with different forms of coronary heart disease
Authors: Aronov D. M
Published: February 2021

The paper presents a review of the main features of a program of the exercises used in the medical rehabilitation of patients with acute and chronic coronary heart disease, including conditions after operations on the heart and vessels. Based on his and literature information, the author states that it is now accepted to use low - to moderate-intensity training exercises. They do not differ from high-intensity exercises in their effectiveness. Furthermore, they are safe, more economical, and convenient. The author gives particular attention to the organizational issues of physical rehabilitation, particularly to multi-sessional trainings using the computerized trainer system.
Self-management of diabetes
Authors: Nedogoda S. V , Salasyuk A. S , Barykina I. N , Khripaeva V. Yu
Published: February 2021

The theory based on the supposition that for the effective treatment of diabetes patients should largely take responsibility for their health, is of no doubt. This is only possible if patients are properly trained to perform continuous monitoring of their disease and have at their disposal some modern easily manageable blood glucose meters that meet international standards and. The present article highlights the changes in the last revision of national guidelines related to the treatment of self-control, as well as existing modern demands in instrumentation for glycemic control.
The optimization of the drug therapy in patients with resistant hypertension (clinical analysis)
Authors: Rodionov A. V
Published: February 2021

The article (case history) discusses the strategy of management of the patient with resistant hypertension and comorbidity (diabetes, gout) according to current clinical guidelines.
Myocardial metabolic background on chemotherapy and means of their correction
Authors: Vasyuk Yu. A , Shkolnik E. L , Nesvetov V. V , Shkolnik L. D , Varlan G. V , Pilschikov A. V
Published: February 2021

Recent years have seen significant progress in the treatment of many oncologicaldiseases associated with the development of new chemotherapeutic agents. Typically, they are used in combination with classical chemotherapy regimens that in-clude doxorubicin. In the background of this combined treatment significant prolongation of life of the patients was noted, but at the same time the risk of cardiotoxicity was considerably increased. The survey provides information about the cardiomyocytesmetabolic disorders during therapy with anthracyclines, discussing the possibility of pathogenetic treatment and prevention.
Comparative analysis of the efficiency of the selective b-blocker nebivolol and the angiotensin II receptor blocker valsartan in men with hypertension, metabolic syndrome, and erectile dysfunction
Authors: Nedogoda S. V , Salasyuk A. S , Barykina I. N , Ledyaeva A. A , Tsoma V. V , Chumachek E. V
Published: February 2021

Objective: to evaluate the antihypertensive efficacy and effect of nebivolol and valsartan on metabolic parameters and erective function in patients with hypertension, metabolic syndrome, and erectile dysfunction. Subjects and methods. A 12-week randomized, blind, controlled, parallel-group, comparative (nebivolol versus valsartan) trial enrolled 40 patients with hypertension, metabolic syndrome, and erectile dysfunction. Results. There were no significant differences between the drugs in their antihypertensive efficiency. Nebivolol exerted a more pronounced positive effect on cardioand angioprotection and lipid and carbohydrate metabolic parameters. It had no negative effect on metabolic parameters. Therapy with nebivolol versus valsartan produced a pronounced positive effect on blood androgen levels and erectile function. Moreover, the quality-of-life indicators also showed a significant improvement in the nebivolol group. Evaluation of the tolerability and adverse reactions of the drugs demonstrated no side effects in both groups.
Assessing the impact of antihypertensive therapy on ambulatory blood pressure monitoring in patients with isolated systolic hypertension
Authors: Aydarova V. A , Astahova Z. T , Kanukova F. U , Besaeva M. M
Published: February 2021

The study examined the effectiveness of drug correction of high numbers of blood pressure (BP) by means of modern groups of antihypertensive drugs, the effect of a fixed combination of perindopril and indapamide on circadian blood pressure monitoring, and a commitment to patients of antihypertensive therapy, based on the opened simple randomization three groupswere formed: 1st comprised of 21 patients with isolated systolic hypertension (ISAH) and 22 patients with systolic-diastolic hypertension (SDAH) - they all received monotherapy with calcium antagonists (amlodipine 10 mg/day); Group 2 - of 16 ISAH patients and 24 SDAH patients - who received monotherapy with perindopril (2 mg/day) and the third group - of 17 patients with ISAH and 14 patients with SDAH - who received combination therapy with the drug noliprel (Servier) with a fixed combination of perindopril (2 mg) and indapamide of 0,625 mg. Treatment efficacy was assessed primarily to reduce the absolute numbers of blood pressure, and taken into account as a reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP), uncontrolled drop of which, according to the literature, in elderly patients can have fatal consequences
Application of lercanidipine in the treatment of hypertension
Authors: Shehyan G. G , Yalymov A. A , Zadionchenko V. S , Varentsov S. I
Published: February 2021

The article presents data from clinical trials that have examined the efficacy and safety of modern calcium antagonist (CA) III generation of lercanidipine. The results of studies show that treatment with lercanidipine leads to a marked reduction in systolic and diastolic blood pressure without significant effect on heart rate. Unique pharmacokinetic characteristics of the drug provide its excellent efficacy and safety, good tolerability, convenience, acceptance and high adherence CA data in patients with hypertension. Additional properties of lercanidipine allow us to recommend the use of the CA in comorbidity.
Interrelation of polymorphic allelic rs619203 option of a gene receptor of a tirozinkinaza (ROS1) with cardiovascular diseases at patients with an ischemic stroke
Authors: Nikulin D. A , Shulman V. A , Prokopenko S. V , Nikulina S. Yu , Chernova A. A , Platunova I. M , Chernov V. N
Published: February 2021

Studying of interrelation of polymorphic allelic rs619203 option of a gene of ROS1 with cardiovascular diseases at persons with the ischemic stroke is carried out. For the purpose of studying of a role of single nucleotide polymorphism of rs619203 of a gene of ROS1 in development of strokes of a genotiping 124 patients with ischemic stroke and cardiovascular pathology and 475 people of group of control. Persons with ischemic stroke are divided into subgroups according to a sex, the affected artery, the diseases which are available cardiovascular, risk factors, such as the raised body weight index, the burdened heredity on a stroke, smoking. For verification of the diagnosis by all patient standard neurologic examination, a computer tomography of a brain, and also the retrospective analysis of results of the previous inspections (are conducted at their existence), for definition of a genotype on ROS1 gene ONP - molecular and genetic research DNA. The received results showed prevalence of a homozygous genotype of GG on extended allel among patients from ischemic stroke having the arterial hypertension in comparison with control group. Thus, the genotype of GG has conditionally protective effect concerning development of ischemic stroke in persons with arterial hypertension.
Self-monitoring of blood glucose in patients with diabetes and cardiac pathology with the Meter Contour TS use
Authors: Kochergina I. I
Published: February 2021

The article presents data on the prevalence of diabetes, the role of hyper - and hypoglycemia in the development of cardiovascular complications, the importance of self-monitoring for early detection of acute complications of diabetes and compensation, as well as the use of Contour TS meter for this purpose.
Stable coronary artery disease - opportunities of non-invasive visualization
Authors: Buziashvili Yu. Iosifovich , Buziashvili V. Yur'evna
Published: February 2021

Nowadays «mechanical» theory of myocardial ischemia is being criticized in both scientific and clinical points of view. Its main point is straight correlation between percent of stenosis of coronary artery and level of myocardial ischemia in segments perfused by «narrowed» coronary artery. Almost every cardiologist has faced clinical situations, when there is no significant ischemia detected during stress-induced tests in segments perfused by coronary artery, that has significant stenosis visualized during coronary angiography. Therefore assessment of functional significance of stenosis is one of main areas of interest among patients with SCAD.In every clinical case most informative test should be chosen in purpose to spot the most appropriate way of treatment and evaluate the need of revascularization. The more accurate diagnostics is done and selection of patient for each way of treatment, the better results we can achieve.
ARB I olmesartan interruption in cardiovascular and cardiorenal continuum: antihypertensive and nephroprotective effects (part 1)
Authors: Bubnova M. G
Published: February 2021

The article provides an overview of the efficacy and tolerability of one of the representatives of the class angiotensin receptor blockers II - olmesartan medoxomil (Kardosal). Analyzed are the characteristics and pharmacological activity of olmesartan medoxomil antihypertensive monotherapy, in combination with other antihypertensive drugs, in different groups of patients. The article describes the renal protective properties of the drug, its safety profile. It also discusses the reasons for poor adherence therapy in patients with arterial hypertension.
The use of ranolazine in the treatment of coronary heart disease
Authors: Zadionchenko V. S , Shehyan G. G , Yalymov A. A , Varentsov S. I
Published: February 2021

The paper presents the study of a new anti-anginal drug - sodium channel inhibitor ranolazine. Considered antianginal, anti-ischemic effect of the drug. Described reduction in angina attacks, increased exercise tolerance and quality of life of patients with stable angina during treatment with ranolazine. Discusses indications, contraindications, side effects, as well as the major clinical trials of the drug ranolazine in patients with coronary heart disease.
Biochemical predictors of coronary atherosclerosis in patients with metabolic disorders
Authors: Surkichin E. M , Shuvaev I. P , Asymbekova E. U , Matskeplishvili S. T
Published: February 2021

Metabolic syndrome represents a combination of different major risk factors of cardiovascular diseases and is mainly related to impaired insulin sensitivity in biological tissues. Common understanding of pathogenesis and relationship of different pathological conditions within metabolic syndrome is still missing. New data on endocrine function of adipose tissue suggests that development and progression of atherosclerosis in this situation may be related to adipokines dysbalance. This study investigates correlation of leptin and adiponectin with clinical and laboratory changes in patients with metabolic disorders.
Awareness of the surveillance of patients with atrial fibrillationamong primary care clinician
Authors: Muromkina A. V , Nazarova O. A , Miasoedova S. E , Romanchuk S. V
Published: February 2021

The study was aimed to understand the knowledge level of physicians in primary care for the management of patients with atrial fibrillation (AF) in various clinical situations. The doctors were surveyed on emergency medical treatment of AF, as well as the tactics of treatment of patients with cardiac arrhythmias in addition to a comorbidity. The author analyzed the most common mistakes made by doctors during management of patients with AF and correlation between dynamics of the knowledge level and professional training of doctors.
Modern approaches to the treatment and long-term management of arterial hypertension in clinical practice. Pharmacological and clinical characteristics of angiotensin II receptor blockers: focus on azilsartan medoxomil. Part I
Authors: Bubnova M. G
Published: February 2021

This article deals withthe overview of the pharmacological characteristics of one class of antihypertensive drugs - angiotensin II receptor antagonists (ARA II) and new member of this class - azilsartan medoxomil (Edarbi®).We have analyzed the antihypertensive efficacy of different ARA, as well as azilsartan medoxomil efficacyin case of monotherapy and in comparison with other ARA and angiotensin-converting enzyme inhibitorsamong different groups of patients.The article describes the pleiotropic effects of azilsartan medoxomil, discovered nowadays.
Medicinal leeches extract at complex treatment of experimental acute myocardial infarction in rats
Authors: Nikonov G. I , Kryzhanovskii S. A , Lebedeva A. O
Published: February 2021

Creating of pharmacological forms based on the medicinal leech extract is a perspective decision of various clinical pathologies. To introduce a new drug into clinical practice is need to investigate its influence on the treatment effectivity at different diseases. The effect of the medicinal leeches Hirudo medicinalis extract for course of experimental acute myocardial infarction in rats was rated. The results of the study indicate the possibility of Hirudo medicinalis extract safe use for complex treatment of myocardial infarction.
Experience of using enoxaparin sodium in the domestic production of emergency cardiology
Authors: Nurmukhamedov L. I , Akhundov R. N
Published: February 2021

The problem of coronary artery atherosclerosis and its associated diseases. It has been found from the viewpoint of clinical application that low molecular weight heparins have important practical advantages, that consist in the simplicity of the drug, more resistant antithrombin effect without need for strict control of a laboratory, and also in security application with the proper dose. Experience indicates a greater use of the efficacy and safety compared to unfractionated heparin.
A quick dynamics of the morphological characteristics of the myocardium in the athlete
Authors: Subbotin P. A , Pavlov V. I , Polianskii N. A , Sharykin A. S , Deev V. V , Badtieva V. A , Ivanova Yu. M
Published: February 2021

The myocardial remodeling of athletes heart is an essential process that occurs in sport exercises. However, depending on the type of load, remodeling can be of different type. An endurance load leading to eccentric cardiac remodeling, whereas power loads cause a concentric transformation of heart. Even in a same sport particular types of load can be different. This causes lead to difficulties in the differential diagnosis of physiological and pathological remodeling. Furthermore, it is believed that there must be sufficient time remodeling. We described the clinical observation, in which the athlete in the same sport, by changing the particularly of the training loads, there is objectively determined transformation of the myocardium in a relatively short period of time.
Renal dysfunction in patients with cardiovascular disease. The effects of blockers of the renin-angiotensinaldosterone system
Authors: Zvereva T. N , Zykov M. V , Barbarash O. L
Published: February 2021

In the article the problem of renal dysfunction in patients with cardiovascular disease is discussed. It describes the basic mechanisms of renal dysfunction and possible ways of influencing them. Including highlights the main classes of drugs that block the renin-angiotensin system aldesteron. The data of several clinical studies confirming the benefits of angiotensin-converting enzyme inhibitors appointment with a dual mechanism of elimination in these patients.
Clinical and psychosocial features of the management of elderly patients with type 2 diabetes mellitus
Authors: Petrova M. M , Pronina E. A , Krizhanovskaya E. V
Published: February 2021

The article describes the clinical and psychosocial particulars of type 2 diabetes mellitus in older adults. Are presented treatment goals and the importance of glycemic control in these patients.
The influence of smoking on the clinical effects of a one-year program of physical rehabilitation of patients of working age who underwent acute myocardial infarction
Authors: Bubnova M. G , Aronov D. M , Krasnitskii V. B
Published: February 2021

Purpose. Study of the clinical effectiveness of a long-term (one-year) physical rehabilitation program with the inclusion of physical training (PT) in the III (polyclinic) stage of cardiac rehabilitation in patients with ischemic heart disease of working age who underwent acute myocardial infarction (AMI), depending on the status of smoking. Materials and methods. The study included men (n = 241, mean age 51.3 ± 2.2 years) who underwent AMI (no earlier than 3 weeks from the event). Patients were randomized into 2 groups: the main ("O") - 126 people and the control ("K") - 115 participants. All patients received standard medication. In the "O" group, PT was used in the medium intensity regime (50-60% of the fulfilled capacity with a load sample) 3 times a week for one year. Each of the groups was divided into two subgroups, depending on the status of smoking. Effectiveness of the effect was assessed by clinical data and results of instrumental-laboratory analysis. Results. After a yearly PT, a significant increase in physical performance was observed in smokers (n=41) and nonsmokers (n=41) and nonsmokers (n=85) after IMI: an increase in the duration of the load (by 30.3%, p
Organization of specialized medical care for patients with chronic heart failure
Authors: Fomin I. V , Vinogradova N. G
Published: February 2021

Relevance. Data from epidemiological studies indicate an increase in the number of patients with chronic heart failure (CHF) in the Russian Federation over the past 18 years. The worsening of the prognosis in patients with CHF after the episode of acute heart failure decompensation (AHFD) requires changes in the tactics of treatment and rehabilitation of patients on an outpatient basis. The goal is to identify the differences in the two strategies for monitoring patients with CHF after AHFD and determine the effectiveness of treatment, rehabilitation and life expectancy, depending on the observation of a specialized urban center for the treatment of CHF (CCHF) and real outpatient practice in the system. Materials and methods. The study included 648 patients with CHF of any etiology older than 18 years. The first group consisted of 412 patients with CHF who were observed for AHFD in the stationary department of the CCHF and, after discharge, continued rehabilitation in the outpatient department of the CCHF; the 2 nd - 236 patients with CHF who, after discharge for AHFD from the department of the CCHF, preferred observation in outpatient clinics in Nizhny Novgorod. Results. After one year of follow-up, the overall mortality rate in the 1st group was 4.13%, and in the second group it was 14.83% (odds ratio 4.0, 95% confidence interval 2.2-7.4, p
Ivabradinum supplements the clinical efficacy of percutaneous coronary intervention in patients with coronary heart disease with stable angina
Authors: Aronov D. M , Bubnova M. G
Published: February 2021

The review is devoted to the role of ivabradinum in the procedure of percutaneous coronary intervention (PCI) in patients with ischemic heart disease with stable angina. It is reported that reperfusion of the myocardium with PCI, even in combination with modern drug therapy, does not have a complete clinical effect. The authors substantiate the possibility of completing the clinical effect of PCI in such patients by prescribing ivabradinum. The drug reduces the heart rate more than with medication without it.
Basic principles of antiplatelet therapy from the perspective of new recommendations
Authors: Bubnova M. G , Mihin V. P
Published: February 2021

In the presented review, some of the main points of the new European recommendations on the use of double antiplatelet therapy (DAT) and triple antithrombotic therapy in patients with coronary heart disease (CHD) with different approaches to its treatment (conservative, invasive and surgical) are outlined. The positions of acetylsalicylic acid (ASA) are designated as the primary basis of a prophylactic antiplatelet strategy. Attention is paid to a new risk stratification for the calculation of the duration of DAT, recommendations for the proper choice of receptor inhibitors for adenosine diphosphate type P2Y12, for switching between oral inhibitors of P2Y12 and for the duration of DAT in different forms of CHD. The review discusses adherence to therapy with ASA and DAT.
The level of uric acid and its role at early stages of essential hypertension
Authors: Oshchepkova Elena Vladimirovna , Dmitriev V A , Polovitkina O V , Titov V N
Published: February 2021

Aim: correlation of uric acid (UA) level on serum blood and urine with indicators of not specific inflammation and clinical
characteristic in essential hypertension (EH) patients. Methods: 67 patients with EH (48 men) 30-65 years age (442) with
stage 1 EH (n=37) and 2 (n=30) with moderate or high cardiovascular (CV) risk. The control group - 14 healthy peoples: (6
men) 45,52,1 years age with normal blood pressure (BP). The normal level of С-reactive protein (CRP) is less 3 mg/l. The
normal level of UA in blood is 202,3-416,5 mkmol/l, and in urine is 1,48-4,43 mmol/24 hour. The estimates of creatinine
clearance by the Cockroft-Gault formula. Results: the patients with EH have bigger level CRP, UA in blood and urine than
healthy peoples with normal BP. Higher levels UA in blood and urine have patients even with early stages EH and moderate
CV risk. The bigger level of UA in blood has EH patients with obesity and dyslipidaemia. The level of UA in blood and urine is
higher at EH patients with hyperfiltration vs patients with normal creatinine clearance. Conclusion: the patients with early
stage of EH have higher level of UA in blood and urine than healthy peoples with normal BP. The level of UA in blood and
urine is correlated with dyslipidaemia. Key words: essential hypertension, uric acid, non specific inflammation
Analysis of antihypertensive therapy and its adherence in hypertensive patients with and without concomitant diabetes mellitus
Authors: Sergeyeva V A
Published: February 2021

Among patients with hypertension and with a combination of hypertension and diabetes mellitus the majority does not reach target values of arterial pressure levels. There is a number of lacks in ambulatory antihypertensive therapy and adherence to it. The considerable number of patients continues to accept therapy irregularly, the choice of antihypertensive drugs and their combinations is not always adequate, non – medicamentous actions don’t realize by all patients. At the same time the powerful negative contribution is associated with low adherence of patients to spent antihypertensive therapy.
The capacities of automated oscillometric blood pressure measuring devices in patients with atrial fibrillation
Authors: Rogoza A N , Goriyeva Sh B
Published: February 2021

Beat-to-beat variability of blood pressure (BP) hampers its exact measurements in patients with arrhythmias, which can give rise to diagnostic inaccuracies and accordingly wrong treatment. Aim: to assess whether BP measurement might be exact in patients with permanent atrial fibrillation when using the latest generation of high-accuracy oscillometric devices. Subjects and methods. The developed design was used to examine 15 patients and to make 44 comparisons of BP measurements. The inclusion criteria were permanent atrial fibrillation and evidence for hypertension. Results. BP levels measured by an objective auscultatory method (OAM), a traditional auscultatory method (TAM), and OMRON M6 device were compared. Considerable (more than 10 mm Hg) differences were found in the recordings taken by OAM and OMRON M6 during 6 (14%) systolic BP (SBP) and 4 (9%) diastolic BP (DBP) measurements. However, substantial differences were concurrently revealed in those obtained by the two auscultatory methods TAM and OAM in 3 (7%) and 4 (9%) measurements of SBP and DPB, respectively; which appears to be related to the general problems of BP measurements in arrhythmias. Conclusion. The conducted pilot study has generally confirmed that the up-to-date high-grade oscillometric tonometers (such as an OMRON 6) may be used to measure SBP and DBP levels in the presence of atrial fibrillation.
Angiotensin-converting enzyme inhibitors or sartans in patients at high risk for cardiovascular events: a wrong question or an undesirable answer
Authors: Gilyarevsky S R , Orlov V A , Kuzmina I M , Golshmid M V
Published: February 2021

The paper discusses current views on the role of using angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers to prevent severe cardiovascular events. It gives both respective documentary information and experts’ opinions. The possible causes of clinical inertness defining deviations in the tactics of using drugs that suppress the activity of the renin-angiotensin system are considered.