bluuebunny/crossref_metadata_2025 huggingface dataset:
Competencia judicial internacional respecto de actos desleales con los competidores = International Jurisdiction in respect of unfair acts with competitors
Authors: Espiniella Menéndez Ángel
Published: October 2018

Resumen: Tras presentar la problemática de la competencia judicial internacional respecto de ac­tos desleales contra competidores en el epígrafe I, en el apartado II se analizan las estrategias procesales a seguir, que básicamente pueden ser de tres tipos: la pactada entre las partes litigantes; la general, válida para cualquier materia patrimonial; y la específica para actos de competencia desleal. En el epígrafe III, se proyectan estas estrategias en la distinta morfología de las conductas desleales, según las esferas de interés de los competidores perjudicados: sus activos intangibles, sus relaciones en el mercado y sus gru­pos de interés (clientes, proveedores, trabajadores…). En el apartado IV, y precisamente por esta morfo­logía tan específica, se analizan las zonas limítrofes con otras normas de competencia, principalmente, en materia de contratos, en materia de propiedad industrial y en materia concursal. La valoración final es que, debido al silencio de las normas de competencia en materia de competencia desleal, se depende en exceso de la construcción jurisprudencial del TJUE, la cual tiene luces y sombras.Palabras clave: competencia judicial internacional, competencia desleal, competidores, materia extracontractual, lugar del hecho dañoso, activos del competidor, relaciones con los competidores, gru­pos de interés del competidor.Abstract: After presenting the issues of international jurisdiction regarding unfair acts against competitors in section I, in section II the litigation strategies are analyzed, which basically can be of three types: one based on the agreement of the parties; second one based on general rules for any eco­nomic matter; and the third one based on specific rules. In section III, these strategies are projected in the different morphology of unfair acts, according to the areas of interest of the injured competitors: their intangible assets, their relationships in the market and their stakeholders (customers, suppliers, workers...). In section IV, and precisely because of this very specific morphology, the bounderies with other jurisdiction rules are analyzed, mainly in matter of contracts, intellectual property and insolvency. The final assessment is that, due to the silence of the jurisdiction rules in respect of unfair competition, we excessively depend on the case law construction of the CJEU, which has lights and shadows.Keywords: international jurisdiction, unfair competition, competitors, non contractual matters, pla­ce of harmful event, assets of the competitor, relations with competitors, stakeholders of the competitors.
Libertad de testar y libertad de elegir la ley aplicable a la sucesión = Freedom of testation and freedom of choice of the law applicable to the succession
Authors: Fontanellas Morell Josep María
Published: October 2018

Resumen: De entre las aportaciones del Reglamento 650/2012, relativo a las sucesiones transfron­terizas, sobresale la introducción de la elección de la ley sucesoria por parte del causante. Para justificar la institución y su inclusión en el instrumento europeo es fácil imaginar una suerte de correlación natural entre la libertar de testar existente en Derecho civil y la posibilidad de designar la ley aplicable propia de las herencias internacionales. Con todo, la doctrina prefiere invocar la seguridad y previsibilidad que la professio iuris proporciona en la planificación de la sucesión. No es ésta, sin embargo, la línea que está siguiendo la jurisprudencia registral española, pues, en sus resoluciones, se ha basado más en la libertad de testar que en la seguridad jurídica.Palabras clave: sucesión mortis causa, libertad de testar, sucesiones internacionales, elección de la ley sucesoria, elección tácita, seguridad jurídica.Abstract: Among the features of Regulation 650/2012, on cross-border successions, the introduc­tion of the testator’s choice of the succession law stands out. In order to justify the institution and its inclusion in the European instrument, it is easy to imagine a kind of natural correlation between the free­dom of testation, granted by national law, and the possibility to select the applicable law which is charac­teristic of international inheritances. Nevertheless, scholars tend to invoke the security and predictability that professio juris provides in the estate planning. Yet resolutions stemming from Directorate General for Registries and Notary Affairs are based more on the freedom of testation than on legal certainty.Keywords: succession upon death, freedom of testation, cross-border successions, choice of law, tacit choice of law, legal certainty
Información engañosa sobre un producto y derecho antitrust = Misleading information about a product and antitrust law
Authors: Framiñán Santas Javier
Published: October 2018

Resumen: La difusión de información engañosa sobre un producto puede, en determinadas cir­cunstancias, restringir la competencia. Este trabajo analiza cuál es el estándar adecuado para evaluar este tipo de práctica a la luz del Derecho de Defensa la competencia de la UE.Palabras clave: información engañosa, Derecho de la competencia, Hoffman La Roche/Novartis. Abstract: Dissemination of misleading information about a product can be considered a restriction of competition under certain conditions. This paper analyses what standard should be employed in the light of the EU Competition Law to evaluate such practice.Keywords: misleading information, competition law, Hoffman La Roche/Novartis.
Environmental taxation and the need for tax limits in the EU legal system = Fiscalidad ambiental y la necesidad de límites tributarios en el ordenamiento jurídico de la UE
Authors: López Espadafor Carlos María
Published: October 2018

Abstract: In spite of the fact that almost all the European Union member States have similar princi­ples of tax justice, there is not an express specification about them in the Primary Law of the Union. The institutions of the European Union have some tax competences given by their member States, specially highlighting fiscal harmonization of certain state taxes. The tax harmonization directives, despite this lack of express specification, cannot forget these principles of tax justice. The argument of the environmental taxation of hydrocarbons has been used to increase the fiscal pressure over the gasoline until a point where its legitimacy should be discussed, not only from the constitutional point of view, but also from the Euro­pean Union Treaties. Individual States are not the only ones responsible for this situation but also European Union institutions are, since the tax on mineral oils has been harmonized by European Union directives.Keywords: environmental taxation, European Union, limits.Resumen: A pesar del hecho de que en la mayoría de los Estados miembros de la Unión Europea existen unos principios de justicia tributaria similares, no existe una especificación expresa de éstos en el Derecho Originario de la Unión. Las instituciones de ésta tienen determinadas competencias en materia tributaria atribuidas por sus Estados miembros, especialmente en relación a la armonización fiscal de ciertos impuestos estatales. Las directivas de armonización fiscal, a pesar de esta falta de especificación expresa, no pueden olvidar estos principios de justicia tributaria. El argumento de la fiscalidad ambiental de los hidrocarburos ha sido utilizado para incrementar la presión fiscal sobre los carburantes hasta un nivel con respecto al cual sería discutible su legitimidad, no sólo desde el punto de vista constitucional, sino también desde la perspectiva de los Tratados de la Unión Europea. Los Estados individualmente considerados no son los únicos responsables de esta situación, sino que también lo son las instituciones de la Unión Europea, desde el momento en que la imposición sobre hidrocarburos se encuentra armoni­zada conforme a directivas de la Unión.Palabras clave: fiscalidad ambiental, Unión Europea, límites.
La respuesta europea a las “empresas buzón”: normas y jurisprudencia en el ámbito social, tributario y de transporte = A European response to “letterbox companies” in social, tax and transport: rules and case
Authors: Llobera Mireia
Published: October 2018

Resumen: El presente trabajo estudia la respuesta comunitaria a las prácticas empresariales que pretenden, mediante sociedades ficticias, eludir las normas de acceso al mercado con el objetivo de obtener ventajas competitivas, y que vienen siendo denominadas “empresas buzón”. En particular, se analizará cómo aborda esta cuestión la Directiva 2014/67/UE relativa a la garantía de cumplimiento de la Directiva 96/71/CE relativa al desplazamiento de trabajadores y el Reglamento (CE) n.º 1071/2009 sobre el acceso a la profesión de transportista por carretera; así como las propuestas normativas de la Comisión en el marco del “paquete de movilidad” en lo concerniente al requisito de establecimiento. En definitiva, se establecerán parámetros de eficacia de tales normas, sirviéndonos de las propuestas en el sector de carreteras como paradigma de análisis. Las distintas fórmulas utilizadas por las instituciones comunitarias para hacer frente a este tipo de prácticas — en el ámbito social, fiscal y sectorial— se des­cribirán críticamente; así como los pronunciamientos que en las últimas décadas han ofrecido criterios interpretativos para la identificación de tales “empresas buzón”.Palabras clave: dumping social, empresas buzón, libertades comunitarias, desplazamiento trasna­cional de trabajadores, evasión fiscal, paquete de movilidad, transporte por carretera.Abstract: This piece of research studies EU response to the practices that pretend, through ficti­tious societies, to elude the norms of access to the market with the objective of obtaining competitive ad­vantages, often called “letterbox companies”. In particular, case-law and regulations on the enforcement of Directive 96/71/EC concerning the posting of workers shall be analyzed under the light of normative proposals of the EU Commission in the framework of the “mobility package”. In short, parameters of effectiveness of such standards shall be established, taking proposals in the road sector as analytical paradigm. Different formulas used by the Community institutions, in social, tax and sectorial areas will be described critically; as well as ECJ rulings that in the last decades have offered interpretative criteria for the identification of such “letterbox companies”.Keywords: social dumping, letterbox companies, EU freedoms, posting of workers, tax elusion, mobility package, road transport.
State liability and the enforcement of arbitral awards infringing EU law, a zero-sum game after Tomášová? = Responsabilidad del estado por inejecución de laudos arbitrales que violan el derecho de la UE, ¿un juego de suma cero tras Tomášová?
Authors: Moreiro González Carlos J.
Published: October 2018

Abstract: The CJEU doctrine regarding to commercial arbitration addresses several aspects of the complex relationships between arbitration and EU Law. Nonetheless, since there is no established regulatory standard, the national court’s review of the conformity of arbitration awards with the EU legal order is conducted according to different criteria.As national courts are faced with obligations of varying degrees, there is the risk of detaching themselves from the obligation to protect this legal order, with a corresponding impact on the creation of situations that could give rise to State liability for infringements of EU Law.Although in its judgment in the Tomášová case the CJEU recognizes very restrictive grounds for the liability of a Member State in such circumstances, this does not exclude that such liability could beincurred under less restrictive circumstances either on the basis of internal law or international law.Keywords: arbitration, award, public policy.Resumen: La doctrina del TJUE sobre el arbitraje comercial aborda varios aspectos de las complejas relaciones entre el arbitraje y la legislación de la UE. No obstante, dado que no existe una norma reglamentaria establecida, la revisión del tribunal nacional de la conformidad de los laudos arbitrales con el ordenamiento jurídico de la UE se lleva a cabo de acuerdo con diferentes criterios.Dado que los tribunales nacionales se enfrentan a obligaciones de diverso grado, existe el riesgo de desvincularse de la obligación de proteger este ordenamiento jurídico, con el consiguiente impacto en la creación de situaciones que podrían dar lugar a la responsabilidad del Estado por infracciones del Derecho de la UE.Aunque en su sentencia en el asunto Tomášová, el TJUE reconoce motivos muy restrictivos para la responsabilidad de un Estado miembro en tales circunstancias, esto no excluye que dicha responsabilidad pueda incurrirse en circunstancias menos restrictivas, ya sea sobre la base del derecho interno o del derecho internacional.Palabras clave: arbitraje, laudo,orden público.
Party autonomy and the law applicable to the matrimonial property regimes in Europe = La autonomía de la voluntad y la ley aplicable a los regímenes matrimoniales en Europa
Authors: Alina Oprea Elena
Published: October 2018

Abstract: In a private international law context reflecting significant divergences between the ob­jective choice-of-law rules for matrimonial property regimes, the principle of party autonomy appears as a salutary solution, bringing certainty, predictability and simplicity, while satisfying also the spouses’ substantial interests. The study focuses on the rules devoted to this principle by the European legislator in the (EU) Regulation no 2016/1103, attempting to outline its regime and insisting, particularly, on its admissibility and on the limitations that accompany its practical exercise. Providing a sufficient fra­mework for discussion and helping to illustrate the implications of the European text, the rules of the Romanian Civil Code and of the 1978 Hague Convention on the law applicable to matrimonial property regimes will serve as a benchmark.Keywords: matrimonial property regimes, EU Regulation no 2016/1103, autonomy of will, electio juris agreements, states with more than one legal system, change of the applicable law.Resumen: En un contexto de derecho internacional privado que refleja divergencias significativas entre las reglas objetivas de elección de los regímenes matrimoniales, el principio de autonomía de las partes aparece como una solución saludable, aportando certeza, previsibilidad y simplicidad, al tiempo que satisface también los intereses sustanciales de los cónyuges. El estudio se centra en las normas dedicadas a este principio por el legislador europeo en el Reglamento (UE) n. ° 2016/1103, que intenta delinear su régimen e insistir, en particular, en su admisibilidad y en las limitaciones que acompañan a su ejercicio práctico. Proporcionar un marco suficiente para el debate y ayudar a ilustrar las implicaciones del texto europeo, las normas del Código Civil rumano y del Convenio de La Haya de 1978 sobre la ley aplicable a los regímenes matrimoniales de propiedad servirán como punto de referencia.Palabras clave: regímenes económicos matrimoniales, Reglamento (UE) no 2016/1103, auto­nomía de la voluntad, acuerdo de elección de la ley aplicable, estados con diversos regímenes jurídicos, cambio de la ley aplicable.
Measure and discipline in world procurement markets = Medición y reglas de los mercados mundiales de contratación pública
Authors: Zapatero Miguel Pablo , Petz Marc
Published: October 2018

Abstract: The revised Government Procurement Agreement (GPA) illustrates the long-term trans­formation in the way governments currently deliver public policies: steering, not rowing. Under a re­gulatory paradigm based on improving efficiency and best value for money, the 51 GPA Parties have reformed the previous GPA framework and expanded global procurement markets in accordance. Howe­ver, the figures of this structural policy trend have not yet been properly mapped. This research estima­tes on basis of the available data that the GPA parties cover round 26% (US$2,140bn) of their GGCE (US$8,220bn), whereby the global GPA coverage could potentially be expanded substantially (compare to global GGCE: US$13,100bn) on the long term.Keywords: public-private partnerships, world trade, market-formation, government procurement, GPA.Resumen: El Acuerdo de Contratación Pública (GPA) revisado ilustra la transformación de largo plazo en la forma en que los Estados desarrollan políticas públicas: guiar, y no remar. Bajo un paradigma regulatorio basado en la mejora de la eficiencia y el mejor valor por el dinero, los 51 Miembros del GPA revisado han reformado el marco legal originario y contribuido a expandir los emergentes mercados glo­bales de contratación pública. Esta investigación calcula en base a los datos disponibles que las partes del GPA cubren un 26% (2.140.000 US$) de su GGCE (8.220.000 US$), mientras la cobertura global del GPA podría expandirse de manera significativa (comparar con el GGCE global: 13.100.000 US$) a largo plazo.Palabras clave: partenariados público-privados, comercio mundial, formación de mercados, con­tratación pública, GPA.
Régimen económico matrimonial, derechos sucesorios del cónyuge supérstite y Certificado Sucesorio Europeo: ¿una combinanción explosiva? = Matrimonial property regimen, succession rights of the surviving spouse and European Certificate of Succession: an explosive
Authors: Antón Juárez Isabel
Published: October 2018

Resumen: El objeto del presente trabajo es el estudio de la STJUE de 1 de marzo de 2018, cono­cido como asunto Mahnkopf. Este asunto es interesante no sólo por lo que recoge el TJUE sino también por lo que calla. Esto es así porque este caso trae a colación problemas jurídicos de gran calado para el Derecho internacional privado como el problema de la calificación. Pero sobre todo pone sobre la mesa un aspecto que va a ser clave en el Derecho europeo de sucesiones y es la relación entre el Derecho suce­sorio y los aspectos relativos al régimen económico matrimonial y cómo estas cuestiones pueden quedar reflejadas en el nuevo instrumento creado por el Reglamento 650/2012, el certificado sucesorio europeo.Palabras clave: Derechos sucesorios, certificado sucesorio europeo, régimen económico matrimo­nial, Reglamento europeo de sucesiones.Abstract: The goal of this paper is to the Judgment of the European Court of Justice of 1 March 2018, Known as Mahnkopf affair. This case is interesting not only because of what the CJEU establishes but also because of what is silent. This is because this case brings up legal problems of great importance to private international law such as the problem of qualification. But above all, it puts on the table an aspect that will be key in European succession law. It is the relationship between succesion law and aspects related to the matrimonial property regime and how these elements can be reflected in the new instrument created by the Regulation 650/2012, the European Certificate of Succession.Keywords: Succesion rights of the surviving spouse, European certificate of succesion, matrimo­nial property regime, European succession regulation.
Sustracción internacional de menores y Convenio de la Haya de 1980. Comentario de la sentencia de la Audiencia Provincial de Las Palmas (Sección 3ª) núm. 377/2017, De 29 de junio = Child abduction and the Hague Convention on 1980. Comment on the judgment of the Spanish Court of Appeal of Las Palmas de Gran Canaria (Section 3) number 377/2017 of 29th june
Authors: Azcárraga Monzonís Carmen , Quinzá Redondo Pablo
Published: October 2018

Resumen: Sustracción internacional a España de menor residente en Argentina en aplicación del Convenio de La Haya de 1980 sobre los aspectos civiles de la sustracción internacional de menores.Palabras clave: sustracción internacional de menores, Convenio de La Haya sobre sustracción, derecho de custodia, filiación.Abstract: International abduction to Spain of a minor residing in Argentina under the Hague Con­vention on the Civil Aspects of International Child Abduction of 1980.Keywords: International child abduction, Hague Convention on Child Abduction, rights of custo­dy, filiation.
La aplicación en España de los dictámenes de comités internacionales: la STS 1263/2018, un importante punto de inflexión = The application in Spain of the opinionsof international committees: STS 1263/2018, an important turning point
Authors: Gutiérrez Espada Cesáreo
Published: October 2018

Resumen: La STS 1263/2018, de 17 de julio, acepta la aplicación en España del dictamen de un comité internacional creado en el marco de un tratado de derechos humanos del que España es parte y respecto del que aceptó expresamente la competencia de dicho comité para pronunciarse sobre recla­maciones individuales. Y de conformidad con su dictamen, condena al Estado al pago de una indemni­zación como reparación de los daños morales causados a la recurrente. El TS, con su sentencia, rompe con la situación anterior y acepta la relevancia en nuestro Derecho interno de los compromisos inter­nacionales asumidos por nuestro país en materia de derechos y libertades fundamentales de la persona. Bienvenida sea.Palabras clave: efecto en España de los dictámenes de Comités internacionales, Ángela González Carreño, responsabilidad patrimonial de la Administración.Abstract: The STS 1263/2018, of July 17, accepts the application in Spain of the opinion of an international committee created by a treaty of Spain is part, committee in respect of which our country expressly accepted its competence to resolve individual claims. And in accordance with its ruling, it condemns the State to pay compensation as reparation to the appellant for the moral damages suffered. With this sentence, our TS breaks with the previous situation and accepts the relevance in our national Law of the international commitments of Spain on rights and fundamental liberties of the person. Wel­come, be it.Keywords: effect in Spanish of the opinions of international committees, Angela Gonzalez Car­reño, patrimonial responsability of the admmistration.
Adopción en España de menores en situación de Kafala y Ley Nacional del Adoptando = Adoption in Spain and National Law of the Adopting
Authors: Sánchez Cano Mª Jesús
Published: October 2018

Resumen: La ley española sólo ofrece dos posibles soluciones a los ciudadanos que constituyen una Kafala en un país islámico: el reconocimiento, sin más pretensiones, a través del artículo 34 LAI o la constitución de una nueva adopción en España conforme a la ley española. Ahora bien, el artículo 19.4 LAI impide la adopción cuando la ley nacional del adoptado la prohíba o no la contemple, lo que sucede en la mayor parte de los Estados musulmanes. Corresponde a los Tribunales españoles interpretar el sentido de esta prohibición, atendiendo las circunstancias del caso concreto y en particular, al grado de integración del menor en nuestro país, junto con las posibilidades de que se constituya una adopción claudicante.Palabras clave: adopción, Kafala, Ley de Adopción internacionalAbstract: Spanish law only offers two possible solutions to the citizens which constitute a Kafala on an Islamic country: the recognition, without more pretensions, through article 34 LAI or the creation of a new adoption in Spain in accordance with Spanish law. Now, article 19.4 LAI prevents the adoption when the adopted national law prohibits it or do not regulate it, what happens in most of the Muslim States. It corresponds to the Spanish courts interpret the meaning of this prohibition, taking account of the circumstances of the specific case and in particular to the degree of integration of the child in our country, along with the possibilities of that constitute a claudicator adoption.Keywords: adoption, Kafala, International Adoption Law.
Fluoroquinolone-Resistant Escherichia coli Infections after Transrectal Biopsy of the Prostate in the Veterans Affairs Healthcare System
Authors: Saade Elie Antoun , Suwantara Nuntra , Zabarsky Trina F. , Wilson Brigid , Donskey Curtis J.
Published: October 2018

Background: Recent reports suggest that infections due to fluoroquinolone-resistant Escherichia coli (E. coli) are an increasingly common complication of transrectal biopsy of the prostate (TBP) in the United States. A better understanding of the magnitude and scope of these infections is needed to guide prevention efforts. Our objective is to determine whether the incidence of infections due to fluoroquinolone-resistant E. coli after TBP has increased nationwide in the Veterans Affairs Health Care System and to identify risk factors for infection.Methods: We performed a retrospective, observational cohort study and a nested case-control study within the US Deparment of Veterans Affairs Healthcare System. The primary outcomes were the incidence of urinary tract infection (UTI) and bacteremia with E. coli and with fluoroquinolone-resistant E. coli strains within 30 days after TBP. Secondary endpoints focused on the correlation between fluoroquinolone-resistance in all urinary E. coli isolates and post-TBP infection and risk factors for infection due to fluoroquinolone-resistant E. coli infection.Results: 245 618 patients undergoing 302 168 TBP procedures from 2000 through 2013 were included in the cohort study, and 59 469 patients undergoing TBP from 2011 through 2013 were included in the nested case-control study. Between 2000 and 2013, there was a 5-fold increase in the incidence of E. coli UTI (0.18%–0.93%) and a 4-fold increase in the incidence of E. coli bacteremia (0.04%–0.18%) after TBP that was attributable to an increase in the incidence of fluoroquinolone-resistant E. coli UTI (0.03%–0.75%) and bacteremia (0.01%–0.14%). The increasing incidence of fluoroquinolone-resistant E. coli infections after TBP occurred in parallel with increasing rates of fluoroquinolone-resistance in all urinary E. coli isolates. By multivariable logistic regression analysis, independent risk factors for fluoroquinolone-resistant E. coli UTI after TBP included diabetes mellitus, fluoroquinolone exposure, prior hospitalization, and prior cultures with fluoroquinolone-resistant gram-negative bacilli.Conclusion: In the Veterans Affairs Healthcare System, the incidence of E. coli infection after TBP has increased significantly since 2000 due to a dramatic rise in infections with fluoroquinolone-resistant E. coli.Keywords: bacteremia; case-control studies; cohort studies; early detection of cancer; Escherichia coliinfections; microbial drug resistance; postoperative complications; prostate; retrospective studies; United States Department of Veterans Affairs; urinary tract infections.
La percepción del maltrato en la formación médica.
Authors: Sarabia Silvana
Published: October 2018

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Paramnesia reduplicativa: a propósito de un caso asociado a esquizofrenia.
Authors: Strobbe-Barbat Mariella , Macedo-Orrego Luis , Cruzado Lizardo
Published: October 2018

Los síndromes de falsa identificación delusional (SFID) constituyen un cuadro clínico relativamente frecuente en la casuística psiquiátrica aunque la paramnesia reduplicativa (PR) se ha atribuido con más frecuencia a causas de tipo orgánico cerebral. Presentamos el caso de un paciente con diagnóstico de esquizofrenia paranoide, que desarrolló paramnesia reduplicativa afirmando que poseía dos domicilios iguales, uno verdadero y otro falso -copia del primero-, pero en este último no podía respirar porque no disponía de aire. Dentro de una breve revisión de la literatura respectiva, hallamos progresos en la explicación neurobiológica de la PR, sobre todo a partir del fenómeno hallado en pacientes con organicidad cerebral, sin embargo subsisten preguntas que pueden requerir una concepción más abarcativa de este síntoma en cuanto manifestación psicótica de la esquizofrenia.
Spatial propagation of streamflow data in ungauged watersheds using a lumped conceptual model
Authors: Kim N. W. , Jung Y. , Lee J. E.
Published: October 2018

Streamflow data are required for the effective management of flood damage; however, streamflow is rarely measured in small watersheds. In this study, a lumped conceptual model was adopted to generate streamflow values at small, ungauged watersheds using the spatial propagation concept. During the process of spatial propagation, parameters related to physical properties were fixed, while event-based initial conditions were optimized to ensure that error rates on the simulated streamflow data were comparable to those for measured data. Then the concept was validated using data from 21 flood events in the ChungJu Dam (CJD) watershed, Korea, which was divided into 22 small, ungauged watersheds. The propagated peak streamflow data at ungauged cross-validation points have average Nash-Sutcliffe efficiency (NSE) values of 0.91–0.99. Averages of NSE values for volume and time to peak streamflow are over 0.85 which satisfies the model criterion (NSE > 0.5). It is concluded that streamflow data for small, ungauged watersheds located upstream can be generated by one gauged downstream streamflow without an extensive amount of gauged streamflow data from other locations using the proposed concept. For accurate simulation, availability of rainfall data is essential for accurately modeling the spatial propagation of streamflow using a lumped conceptual model.
O enredo humorístico na constituição das falsas notícias do Diário Pernambucano
Authors: Silveira Karine
Published: October 2018

Este artigo objetiva analisar a constituição do humor nas falsas notícias humorísticas do site Diário Pernambucano. Os textos que constituem este site, e que os denominamos de falsas notícias humorísticas, são cômicos e baseados, em sua maioria, em informações verificáveis. A temática escolhida para compor o nosso corpus foi a Copa do Mundo de 2014, pois ela foi um importante evento realizado no Brasil. A abordagem teórica sobre textos humorísticos que norteia as nossas análises é proposta por Attardo (2001). Essa abordagem se preocupa com a construção do humor em narrativas mais extensas. Mediante ao quadro teórico utilizado, verificamos que o corpus contém elementos humorísticos que desconstroem o fato, logo, o leitor se depara com algumas incongruências, o que é chamado de oposição de scripts. Isso posto, consideramos que as falsas notícias humorísticas são narrativas, já que se assemelham a notícias, com enredo humorístico, o qual distorce a realidade.
Managing the Patient With Pulmonary Arterial Hypertension and Methamphetamine Use: A Practical Perspective for the Clinician
Authors: Tarango Nimaljeet , Baird Andrea Gergay
Published: October 2018

Pulmonary arterial hypertension (PAH) is a serious, chronic, progressive cardiopulmonary disease. PAH is associated with several concomitant conditions, as well as drugs and toxins.12 Methamphetamine abuse is likely associated with the development of PAH.3 Methamphetamine abuse is epidemic in the United States and abroad, with rates of new users escalating since 2012. There are over 100,000 new users annually as young as 12 years old. Treating a patient with a history of methamphetamine abuse poses many challenges for a clinician, including nonadherence, therapeutic treatment selection, complex psychosocial issues, and relapse or continued drug abuse. Patients with methamphetamine-associated PAH (Meth-APAH) have higher mortality rates when compared to idiopathic PAH.3 Having a better understanding of the complexities of addiction and working with a multidisciplinary team that includes a social worker to provide care and counseling to these patients can improve their trajectory. In this article, we will offer insight and background into methamphetamine abuse and addiction, as well as discuss a practical approach for clinicians in treating a patient with Meth-APAH, based on the literature, as well as our personal experiences at University of California, San Francisco Medical Center.
Anorexigen-Associated Pulmonary Arterial Hypertension and the Serotonin Hypothesis: A Story Worth Telling
Authors: Shah Trushil G. , Bartolome Sonja D. , Chin Kelly M.
Published: October 2018

Diet pills such as aminorex, fenfluramine, and dexfenfluramine have been strongly associated with the development of pulmonary arterial hypertension (PAH). Other drugs ostensibly related in function have also been implicated as “likely” associated, including amphetamine, methamphetamine, and the serotonin precursor L-tryptophan. Serotonin signaling is thought to be a mediator of diet pill–associated PAH, and it is also thought to potentially play a significant role in PAH in general. In this article, we review the evidence supporting the serotonin hypothesis in PAH in both contexts, and the potential concerns related to selective serotonin reuptake inhibitors and other medications acting on serotonin signaling pathways.
Drug-Drug Interactions of P-gp Substrates Unrelated to CYP Metabolism
Authors: Akamine Yumiko , Yasui-Furukori Norio , Uno Tsukasa
Published: October 2018

Background:

Recent US Food and Drug Administration (FDA) draft guidance on pharmacokinetic drugdrug interactions (DDIs) has highlighted the clinical importance of ABC transporters B1 or P-glycoprotein (P-gp), hepatic organic anion-transporting polypeptide transporters and breast cancer resistant protein because of their broad substrate specificity and the potential to be involved in DDIs. This guidance has indicated that digoxin, dabigatran etexilate and fexofenadine are P-gp substrate drugs and has defined P-gp inhibitors as those that increase the AUC of digoxin by ≧1.25-fold in clinical DDI studies. However, when substrate drugs of both CYPs and P-gp are involved in DDIs, it remains that the mechanisms of DDIs will be quite ambiguous in assessing how much the CYPs and/or drug transporters partially contribute to DDIs.

Objective:

Since there are no detailed manuscripts that summarizes P-gp interactions unrelated to CYP metabolism, this article reviews the effects of potent P-gp inhibitors and P-gp inducers on the pharmacokinetics of P-gp substrate drugs, including digoxin, talinolol, dabigatran etexilate, and fexofenadine in human studies. In addition, the present outcome were to determine the PK changes caused by DDIs among P-gp substrate drugs without CYP metabolism in human DDI studies.

Conclusion:

Our manuscript concludes that the PK changes of the DDIs among P-gp drugs unrelated to CYP metabolism are less likely to be serious, and it appears to be convincing that the absences of clinical effects caused to the PK changes by the P-gp inducers is predominant compared with the excessive effects caused to those by the P-gp inhibitors.
Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model
Authors: Uehara Shotaro , Oshio Toru , Nakanishi Kazuyuki , Tomioka Etsuko , Suzuki Miyu , Inoue Takashi , Uno Yasuhiro , Sasaki Erika , Yamazaki Hiroshi
Published: October 2018

Background:

Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models
for preclinical studies. Information for major drug-metabolizing cytochrome P450 (P450) enzymes is now available
that supports the use of this primate species as an animal model for drug development. Here, we collect and provide
an overview of information on the activities of common marmoset hepatic and intestinal microsomes with respect to
28 typical human P450 probe oxidations.

Results:

Marmoset P450 2D6/8-dependent R-metoprolol O-demethylation activities in hepatic microsomes were
significantly correlated with those of midazolam 1′- and 4-hydroxylations, testosterone 6β-hydroxylation, and progesterone
6β-hydroxylation, which are probe reactions for marmoset P450 3A4/5/90. In marmosets, the oxidation
activities of hepatic microsomes and intestinal microsomes were roughly comparable for midazolam and terfenadine.
Overall, multiple forms of marmoset P450 enzymes in livers and intestines had generally similar substrate recognition
functionalities to those of human and/or cynomolgus monkey P450 enzymes.

Conclusion:

The marmoset could be a model animal for humans with respect to the first-pass extraction of terfenadine
and related substrates. These findings provide a foundation for understanding individual pharmacokinetic
and toxicological results in nonhuman primates as preclinical models and will help to further support understanding
of the molecular mechanisms of human P450 function.
Should Cushing's Syndrome be Considered as a Disease with High Cardiovascular Risk in Relevant Guidelines?
Authors: Koracevic Goran , Stojkovic Milan , Lovic Dragan , Pavlovic Milan , Kostic Tomislav , Kutlesic Marija , Micic Sladjana , Koracevic Maja , Djordjevic Milan
Published: October 2018

A considerable amount of data supports a 1.8-7.4-fold increased mortality associated with Cushing’s syndrome (CS). This is attributed to a high occurrence of several cardiovascular disease (CVD) risk factors in CS [e.g. adiposity, arterial hypertension (AHT), dyslipidaemia and type 2 diabetes mellitus (T2DM)]. Therefore, practically all patients with CS have the metabolic syndrome (MetS), which represents a high CVD risk. Characteristically, despite a relatively young average age, numerous patients with CS display a 'high' or 'very high' CVD risk (i.e. risk of a major CVD event >20% in the following 10 years). Although T2DM is listed as a condition with a high CVD risk, CS is not, despite the fact that a considerable proportion of the CS population will develop T2DM or impaired glucose tolerance. CS is also regarded as a risk factor for aortic dissection in current guidelines. This review considers the evidence supporting listing CS among high CVD risk conditions.
Synthesis of Pyridinyl-benzo[d]imidazole/Pyridinyl-benzo[d]thiazole Derivatives and their Yeast Glucose Uptake Activity In Vitro
Authors: Khan Momin , Ahmad Riaz , Rehman Gauhar , Gul Naeem , Shah Sana , Salar Uzma , Perveen Shahnaz , Khan Khalid Mohammed
Published: October 2018

Background:

Diabetes is the primary cause of fatality and disability all over the world, in recent past, we have reported various classes of compounds as anti-glycating agents and we have also reported benzimidazole and benzothiazole derivatives as a potential class of anti-glycating agents. This encouraged us to evaluate the pyridinyl benzimidazole/pyridinyl benzothiazole derivatives 1-27 for yeast glucose uptake activity.

Methods:

In the present study, an equimolar mixture of pyridine carboxaldehyde derivatives (1 mmol) and sodium metabisulphite (1 mmol) in DMF (10 mL) was stirred for 10 to 15 min, followed by addition of o-phenylene diamine/2-aminothiophenol (1 mmol) into it and refluxed for 3 h. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was poured into crushed ice. Precipitates were formed which were collected by filtration to produce compounds 1-27 in good yields. Recrystallization from methanol yielded pure crystals.

Results:

Our present study showed that all compounds showed a varying degree of yeast glucose uptake activity in the range IC50 = 36.43-272.20 µM, compared to standard metronidazole (IC50 = 41.86 ± 0.09 µM). Compounds 5 (IC50 = 38.14 ± 0.17 µM), 6 (IC50 = 40.23 ± 0.20 µM), and 7 (IC50 = 36.43 ± 0.02 µM) showed an excellent yeast glucose uptake activity better than the standard.

Conclusion:

Pyridinyl benzimidazole/pyridinyl benzothiazole derivatives 1-27 were synthesized, structurally characterized, and evaluated for in vitro yeast glucose uptake activity. Compounds 5 (IC50 = 38.14 ± 0.17 µM), 6 (IC50 = 40.23 ± 0.20 µM), and 7 (IC50 = 36.43 ± 0.02 µM) demonstrated potent yeast glucose uptake activity as compared to standard metronidazole (IC50 = 41.86 ± 0.09 µM). This study identified a number of potential lead molecules which can be helpful in lowering the blood glucose level in hyperglycemia.
Schwannomas of Uncommon Peripheral Locations: Analysis of Imaging Findings of 21 Cases
Authors: Gokaslan Cigdem Ozer , Toprak Ugur , Demirel Emin , Erdim Cagri , Yardimci Aytul Hande , Turan Ceyda Bektas
Published: October 2018

Background:

Schwannomas are benign slow-growing tumors most often associated with the cranial nerves. Schwannomas often originate from the eighth cranial nerve. They may also originate from the peripheral nervous system of the neck and extremities. However extracranial peripheral schwannomas are considered a rare entity.

Objective:

The knowledge of rare localizations and typical imaging findings will lead to a successfulradiological diagnosis. Therefore, in this study, we present the clinical findings and MRI characteristics of schwannomas with a rare localization involving the peripheral, lower and upper extremity and intramuscular regions.

Materials and Methods:

The hospital database was screened for patients with an extracranial soft tissue mass. Twenty-one cases of schwannomas were found in rare localization. We analyzed the MR images of these patients retrospectively. The MR images were evaluated in terms of tumor location, signal intensity, and enhancement pattern. The histological examination of all the patients confirmed the diagnosis of schwannoma.

Results:

In 21 patients, the schwannomas were peripheral, localized to upper (n = 6) and lower extremities (n = 11). The remaining four patients had intramuscular schwannomas.

:

The patients diagnosed with intramuscular schwannomas had schwannomas in sternocleidomastoid, gastrocnemius, triceps muscle and lateral wall of the abdomen. The average long-axis diameter of the tumor was 27.7 mm and the average short-axis diameter was 16.4 mm. The contrast pattern was diffused in eight tumors and peripheral in 13.

Conclusion:

In this study, we present clinical findings and MRI characteristics of schwannomas with a rare localization involving the peripheral, lower and upper extremity and intramuscular regions.
Broad Spectrum Peptide Vaccine Design Against Hepatitis C Virus
Authors: Dewi Sherly Kurnia , Ali Soegianto , Prasasty Vivitri Dewi
Published: October 2018

Background: Hepatitis C virus (HCV) infection is a global burden. There is no peptide vaccine found as modality to cure the disease is available due to the weak cellular immune response and the limitation to induce humoral immune response.

Methods:

Five predominated HCV subtypes in Indonesia (1a, 1b, 1c, 3a, and 3k) were aligned and the conserved regions were selected. Twenty alleles of class I MHC including HLA-A, HLA-B, and HLAC types were used to predict the potential epitopes by using NetMHCPan and IEDB. Eight alleles of HLA-DRB1, together with a combination of 3 alleles of HLA-DQA1 and 5 alleles of HLA-DQB1 were utilized for Class II MHC epitopes prediction using NetMHCIIPan and IEDB. LBtope and Ig- Pred were used to predict B cells epitopes. Moreover, proteasome analysis was performed by NetCTL and the stability of the epitopes in HLA was calculated using NetMHCStabPan for Class I. All predicted epitopes were analyzed for its antigenicity, toxicity, and stability. Population coverage, molecular docking and molecular dynamics were performed for several best epitopes.

Results:

The results showed that two best epitopes from envelop protein, GHRMAWDMMMNWSP (E1) and PALSTGLIHLHQN (E2) were selected as promising B cell and CD8+ T cell inducers. Other two peptides, LGIGTVLDQAETAG and VLVLNPSVAATLGF, taken from NS3 protein were selected as CD4+ T cell inducer.

Conclusion:

This study suggested the utilization of all four peptides to make a combinational peptide vaccine for in vivo study to prove its ability in inducing secondary response toward HCV.
Field evaluation of a novel UV water disinfection system for use in underserved rural communities
Authors: Younis Bassam A. , Mahoney Laura E. , Yao Shiyun
Published: October 2018

Reliable, robust, and inexpensive disinfection systems are needed to expand water security in remote and underserviced areas. This paper reports on the deployment and evaluation of a novel UV water disinfection system in a remote rural community. Prior laboratory tests indicated a 7.12 log10 reduction of the bacteriophage MS‐2 at a flow rate of 9.46 L/min, which corresponds to a supplied UV dose 215 mJ/cm2. Further tests in water containing turbidity levels up to 18 NTU showed E. coli removal remaining above the 5 log10 level. Field testing was performed at a Native American reservation in Northern California where the system was used to treat groundwater obtained from a well with a known fecal contamination. The system was powered by solar panel and was operated on‐demand for extended periods. Tests on the treated water showed that the system exceeded the standard of disinfection required for drinking water.

Practitioner points

A novel system for water disinfection with UV light is described.

Laboratory and field tests showed high levels of disinfection achieved even at low UVT and high turbidity.

System is robust, reliable and inexpensive to produce thus suitable for use in underserved communities.
Tendencias actuales de la osteología antropológica en México
Authors: Serrano Sánchez Carlos , Terrazas Mata Alejandro
Published: October 2018

En la historia de la antropología física, el conocimiento de la anatomía del esqueleto humano constituyó uno de los pilares fundamentales de su desarrollo. Respondía a la necesidad de abordar los temas centrales en la construcción de la nueva disciplina: la evolución humana (morfología esquelética de los homínidos fósiles y del hombre prehistórico) y la emergencia, y diversidad biológica del hombre moderno (etnogénesis de los grupos humanos de un pasado histórico más reciente). La antropología física del siglo XIX abundó en este interés, que persiste por lo demás en la antropología contemporánea, desde nuevos planteamientos, enriquecidos con el tiempo.
Xipe Totec, Notre Seigneur l’Écorché. Étude glyphique d’un dieu aztèque
Authors: Dehouve Danièle
Published: October 2018

Xipe Totec, Nuestro Señor el Desollado, es un dios azteca particularmente sanguinario, tanto en sus representaciones como en su ritual el cual se llevaba a cabo en la primavera con la fiesta anual del Desollamiento (Tlacaxipehualiztli). Anne-Marie Vié-Wohrer considera que la divinidad constituye, junto con las ceremonias que se efectuaban en su honor, un "complejo divino" que la autora define como "... el conjunto de representaciones de los personajes divinos y humanos, de objetos y de escenas rituales que rodean a Xipe Totec y a los dioses que se le asimilan" (pág. 23), y que ella analizará a lo largo de su obra.
Manifestación contra el olvido. Contexto, conflicto y símbolo del 2 de octubre de 1998 en la Ciudad de México
Authors: Tamayo Sergio
Published: October 2018

Como una "multitud de ingenuos", así calificó la Arquidiócesis Primada de México a los participantes en la marcha conmemorativa de los 30 años de la matanza de estudiantes en la plaza de Tlatelolco. Pero fue el único sector que se puso, entonces, del lado del gobierno federal. Ni siquiera la Iglesia Nacional Presbiteriana, pues ella la aceptó diciendo: "... si los archivos aclaran los hechos [la matanza de estudiantes que llevó a cabo el ejército, el 2 de octubre de 1968), lo mejor es que se abran. Los medios de comunicación, por su parte, abrieron un enorme espacio para el reportaje y el seguimiento en vivo de la manifestación. En plana completa de los principales diarios nacionales se podía leer la publicidad de Televisa: "Abraham Zabludowsky por el 68: Que hablen los testigos. Esta noche en el noticiero con Guillermo Ochoa". La estación Radio Red siguió paso a paso desde las 15 horas el inicio y la terminación de la marcha. Entonces, la mentada estación no sacó su spot preferido Monitor, no inventó las manifestaciones pero sí la solución: la Red Vial. Todo lo contrario, monitoreó la marcha y los reporteros viales, quienes frecuentemente se convierten en hechizos reporteros políticos, ya que cubren todo el repertorio de la protesta colectiva de la ciudad, también ese día funcionaron como observadores directos de la gran marcha, pero ahora sin satanizarla.