bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase I study of the combination of anti-GD2 antibody 3F8 and barley-derived (1→3,1→4)-β-D-glucan for patients with resistant neuroblastoma
Authors: Modak S. , Kushner B. H. , Kramer K. , Vickers A. , Cheung N.
Published: March 2020

9566

Background: Beta glucans are complex, naturally occurring polysaccharides that prime leucocyte dectin and CR3 receptors. Based on our preclinical observations that oral barley-derived (1→3,1→4)-β-D-Glucan (BG) synergizes with the murine anti-GD2 antibody 3F8 against neuroblastoma (NB) (Clin Cancer Res 8:1217), we conducted a phase I study to determine the safety of the combination of BG and 3F8 in patients with resistant NB. Methods: Heavily pre-treated patients with recurrent or refractory advanced stage NB were treated with 3F8/BG. Each cycle consisted of intravenous (IV) 3F8 at a fixed dose of 10 mg/m2/day ×10 days, plus oral BG dose escalated from 10 to 80 mg/kg/day ×10 days in 4 cohorts of 6 patients each. Patients without human anti-mouse antibody (HAMA) could be re-treated up to a total of 4 cycles. Results: Twenty-three patients with stage 4 and one with stage 3 NB (M:F = 11:13; median age 8 (range 2–19) years completed 47 cycles of therapy with 3F8/BG. 8 patients had progressive disease (PD) while 16 had stable refractory NB (SD) at enrollment. All patients completed at least one cycle of therapy and were evaluated for toxicity and response. Maximum tolerated dose for BG was not reached. Two patients developed dose-limiting toxicities (DLT). Both had grade 4 thrombocytopenia after completing one cycle of treatment: one at BG dose of 20mg/kg/day and the other at 40 mg/kg/day. Both cases responded to therapy with a short course of ITP (idiopathic thrombocytopenic purpura) therapy; one subsequently developed chronic ITP. There were no other >grade 2 toxicities related to 3F8/BG therapy. 14, 4, 2 and 6 patients completed 1, 2, 3 and 4 cycles respectively. Reasons for withdrawal in patients who did not complete 4 cycles were PD in 10, persistently elevated HAMA in 6 and DLT in 2. Overall 11 patients had SD and 13 PD. 14/23 patients with positive MIBG scans prior to therapy demonstrated improvement after one cycle. Responses did not correlate with BG dose received. 7 patients, all with residual disease survive at a median of 40 (range 24–45) months post-treatment. Conclusions: 3F8/BG is well tolerated and shows activity against resistant NB. Further clinical investigation of this novel combination is warranted.

No significant financial relationships to disclose.
Effect of gilteritinib on survival in patients with FLT3-mutated (FLT3mut+) relapsed/refractory (R/R) AML who have common AML co-mutations or a high FLT3-ITD allelic ratio.
Authors: Levis Mark J. , Perl Alexander E. , Martinelli Giovanni , Cortes Jorge E. , Neubauer Andreas , Berman Ellin , Montesinos Pau , Baer Maria R. , Larson Richard A. , Chou Wen-Chien , Yokoyama Hisayuki , Recher Christian , Yoon Sung-Soo , Hill Jason E , Rosales Matt , Liu Charles , Bahceci Erkut
Published: March 2020

7000

Background: The FLT3 inhibitor, gilteritinib, showed superior response and overall survival (OS) compared with salvage chemotherapy (SC) in patients (pts) with FLT3mut+ R/R AML in the phase 3 ADMIRAL study. We analyzed the impact of baseline co-mutations and FLT3-ITD allelic ratio (AR) on response and OS. Methods: A total of 37 recurrently mutated genes in AML (Archer Core Myeloid Panel) were analyzed by next-generation sequencing; the cutoff for co-mutation positivity (co-mut+) was ≥0.027. Baseline FLT3-ITD AR ( FLT3-ITD to FLT3 wild-type DNA) was measured by the LeukoStrat CDx FLT3 Mutation Assay. The median FLT3-ITD AR value of 0.77 was used to define high (≥0.77) vs low (<0.77) FLT3-ITD AR. Results: Analysis of 361 FLT3mut+ pts identified four major co-mutation cohorts, each with ≥10% of pts: NPM1 (n=173; 47.9%), DNMT3A (n=115; 31.9%), DNMT3A/NPM1 (n=86; 23.8%) , and WT1 (n=65; 18.0%). In addition, seven pts (1.9%) had all three co-mutations (ie, NPM1, DNMT3A, and WT1). The gilteritinib arm had superior response rates and OS across all four major co-mutation cohorts, with the greatest survival benefit in pts with DNMT3A/NPM1 co-mut+ (Table). In FLT3-ITD AR analyses (n=335), gilteritinib conferred longer OS than SC in pts with a high or low FLT3-ITD AR (gilteritinib: high FLT3-ITD AR, 7.1 mos vs low FLT3-ITD AR, 10.6 mos; SC: high FLT3-ITD AR, 4.3 mos vs low FLT3-ITD AR, 6.9 mos). In both arms, OS was longer in the low FLT3-ITD AR cohort than the high FLT3-ITD AR cohort but the difference in the gilteritinib arm was not statistically significant (gilteritinib: HR=1.341, P=0.0712; SC: HR=2.01, P=0.0021). Conclusions: The ADMIRAL trial shows that the clinical benefit of gilteritinib in FLT3mut+ R/R AML is maintained regardless of NPM1, DNMT3A, DNMT3A/ NPM1, or WT1 co-mut+ or high FLT3-ITD AR. Clinical trial information: NCT02421939. [Table: see text]
Reducing Infusion Clinic Wait Times Using Quality Improvement
Authors: Plourde Collin L. , Varnado William T. , Gleaton Barbara J. , Das Devika G.
Published: March 2020

PURPOSE:

Long wait times are a common occurrence for chemotherapy infusion patients and are a source of decreased patient satisfaction. Our facility sought to decrease outpatient infusion clinic wait times by 20% using the Model for Improvement, quality improvement tools, and Plan-Do-Study-Act cycles.

METHODS:

A multidisciplinary team was formed to address clinic wait times. Patient interviews, time studies, process mapping, brainstorming sessions, affinity diagrams, fishbone diagrams, and surveys were used to define the problem and to develop an intervention. Wait times from check-in until medication administration were analyzed using statistical process control charts. Our Plan-Do-Study-Act cycle led to the addition of a “fast-track” clinic title for patients not waiting for laboratory results on the day of treatment and changes in clinic communication. The fast-track clinic signaled for those patients to have priority for vital sign collection and earlier notification to pharmacy to begin preparing medications.

RESULTS:

Baseline wait times for patients not requiring laboratories on the day of treatment averaged 1 hour and 33 minutes. After intervention, using statistical process control charts, a shift was observed with a new average wait time of 1 hour and 12 minutes (a 23% decrease). Wait times for patients requiring laboratories on the day of treatment did not change significantly.

CONCLUSION:

Implementation of a fast-track clinic title and improving communication resulted in a significant reduction in wait times for patients not requiring laboratories on the day of treatment. Future efforts will focus on sustainment and improving wait times for all patients.
Bone marrow adipose cells – cellular interactions and changes with obesity
Authors: Boroumand Parastoo , Klip Amira
Published: March 2020

The bone marrow is a spatially restricted niche, housing cells of the hematopoietic and mesenchymal lineages in various hierarchical commitment states. Although highly localized, cells within this niche are also subject to regulation by environmental and/or circulatory changes through extensive vascularization. Bone marrow adipocytes, derived from mesenchymal stem cells and once known as marrow space fillers, are a heterogeneous population. These cells reside in distinct niches within the bone marrow and interact with proximal cells, such as hematopoietic precursors and lineage-committed cells. In this diverse cellular milieu, bone marrow adipocytes influence commitment decisions and cellular lineage selection by interacting with stem and progenitor cells. In addition, bone marrow adipocytes respond to environmental changes, such as obesity, by undergoing hypertrophy, hyperplasia or adoption of characteristics resembling those of peripheral brown, beige or white adipocytes. Here, we review recent findings and concepts on the influence of bone marrow adipocytes on hematopoietic and other cellular lineages within this niche. We discuss how changes in local, systemic, cellular and secreted signals impact on mesenchymal stem cell expansion, differentiation and lineage commitment. Furthermore, we highlight that bone marrow adipocytes may be intermediaries conveying environmental cues to influence hematopoietic cellular survival, proliferation and preferential differentiation.
Leadership for the Team Physician
Authors: Tayne Samantha , Hutchinson Mark R. , O'Connor Francis G. , Taylor Dean C. , Musahl Volker , Indelicato Peter
Published: March 2020

Physician leadership of the interdisciplinary sports medicine team depends on fundamental leadership skills that often are overlooked in medical school. These leadership skills include effective communication, emotional intelligence, teamwork, selfless service, integrity, and critical thinking while utilizing an athlete-centered approach. Development of these skills will help to navigate team management and important decisions, such as return to play. The leadership session at the Advanced Team Physician Course sought to acknowledge the gap in medical training regarding leadership education and began to address it in a forum specifically for team physicians. Here we provide a summary of the lectures and presentations from the 2018 Advanced Team Physician Course in an effort to benefit a broader physician audience. This material should act as a framework for current and future team physicians to solidify their role as the leader of the medical team in caring for the athlete.
Stock markets in Asia, Australia and the Pacific
Authors: Kurakin Roman
Published: March 2020

The monograph describes the basic institutions of exchange rights of States Asia, Australia and the Pacific, analyzes the basic legal acts constituting the exchange legislation of the States, Asia, Australia and the Pacific; examined the procedure of state regulation of the exercise of economic activities on the stock market in Asia, Australia and the Pacific; describes the features of self-regulation of economic activities on the stock market in Asia, Australia and the Pacific.
For students and teachers, and anyone interested in world trade issues and the stock markets of individual regions and States.
The “Evil Pleasure”: Abusive Supervision and Third-Party Observers’ Malicious Reactions Toward Victims
Authors: Xu Erica , Huang Xu , Jia Rongwen , Xu Jane , Liu Wu , Graham Les , Snape Ed
Published: March 2020

We investigated how abusive supervision influences interactions between third-party observers and abused victims and hypothesized when and why third parties react maliciously toward victims of abusive supervision. Drawing on the theory of rivalry, we predicted that third-party observers would experience an “evil pleasure” (schadenfreude) when they perceive a high level of rivalry with the victims of abusive supervision and that the experienced schadenfreude then would motivate third parties to engage in interpersonal destructive behaviors (i.e., undermining, incivility, and interpersonal deviance) toward the victims. We further proposed that such malicious reactions would be attenuated if groups have a high level of cooperative goals. Results based on one experimental study and two time-lagged field studies lend support to our propositions.
Direct to implant breast reconstruction with biological acellular dermal matrices
Authors: Teoh Victoria , Gui Gerald
Published: March 2020

Breast cancer is the most commonly diagnosed female cancer in the UK, with one in eight women receiving a cancer diagnosis during their lifetime. Forty per cent of women diagnosed with breast cancer undergo mastectomy as their primary therapeutic procedure. While a full range of choices is offered, breast reconstruction using implants is the patient-preferred method of reconstruction following mastectomy. This review discusses the evolution of implant-based reconstruction, focusing on the recent trend towards prepectoral breast reconstruction. Key quality indicators in the current literature are considered, including oncological outcomes, aesthetics and patient-related outcome measures, as are the health-care economics of this emerging surgical technique.
Lower extremity peripheral artery disease: a basic approach
Authors: Chan Keith A , Junia Alex
Published: March 2020

Peripheral artery disease of the lower limbs is a chronically progressive disorder characterised by the presence of occlusive lesions in the medium and large arteries that result in symptoms secondary to insufficient blood flow to the lower extremities. It is both a manifestation of systemic atherosclerosis and a marker of increased cardiovascular morbidity and mortality. Because of its highly heterogenous clinical picture, a detailed history and physical assessment, a high degree of suspicion for peripheral artery disease and the use of the ankle–brachial pressure index is essential to identify patients with peripheral artery disease. This will allow early administration of basic pharmacotherapy and lifestyle changes to reduce cardiovascular events, minimise claudication symptoms and enable optimal revascularisation to prevent loss of limb function.
Cigarette smoke inhalation impairs angiogenesis in early bone healing processes and delays fracture union
Authors: Chang Chao-Jui , Jou I-Ming , Wu Tung-Tai , Su Fong-Chin , Tai Ta-Wei
Published: March 2020

Aims

Cigarette smoking has a negative impact on the skeletal system, causes a decrease in bone mass in both young and old patients, and is considered a risk factor for the development of osteoporosis. In addition, it disturbs the bone healing process and prolongs the healing time after fractures. The mechanisms by which cigarette smoking impairs fracture healing are not fully understood. There are few studies reporting the effects of cigarette smoking on new blood vessel formation during the early stage of fracture healing. We tested the hypothesis that cigarette smoke inhalation may suppress angiogenesis and delay fracture healing.

Methods

We established a custom-made chamber with airflow for rats to inhale cigarette smoke continuously, and tested our hypothesis using a femoral osteotomy model, radiograph and microCT imaging, and various biomechanical and biological tests.

Results

In the smoking group, Western blot analysis and immunohistochemical staining revealed less expression of vascular endothelial growth factor (VEGF) and von Willebrand factor (vWF). The smoking group also had a lower microvessel density than the control group. Image and biochemical analysis also demonstrated delayed bone healing.

Conclusion

Cigarette smoke inhalation was associated with decreased expression of angiogenic markers in the early bone healing phase and with impaired bone healing. Cite this article: Bone Joint Res. 2020;9(3):99–107.
Can joint fluid metabolic profiling (or “metabonomics”) reveal biomarkers for osteoarthritis and inflammatory joint disease?
Authors: Akhbari Pouya , Karamchandani Urvi , Jaggard Matthew K. J. , Graça Goncalo , Bhattacharya Rajarshi , Lindon John C. , Williams Horace R. T. , Gupte Chinmay M.
Published: March 2020

Aims

Metabolic profiling is a top-down method of analysis looking at metabolites, which are the intermediate or end products of various cellular pathways. Our primary objective was to perform a systematic review of the published literature to identify metabolites in human synovial fluid (HSF), which have been categorized by metabolic profiling techniques. A secondary objective was to identify any metabolites that may represent potential biomarkers of orthopaedic disease processes.

Methods

A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines using the MEDLINE, Embase, PubMed, and Cochrane databases. Studies included were case series, case control series, and cohort studies looking specifically at HSF.

Results

The primary analysis, which pooled the results from 17 published studies and four meeting abstracts, identified over 200 metabolites. Seven of these studies (six published studies, one meeting abstract) had asymptomatic control groups and collectively suggested 26 putative biomarkers in osteoarthritis, inflammatory arthropathies, and trauma. These can broadly be categorized into amino acids plus related metabolites, fatty acids, ketones, and sugars.

Conclusion

The role of metabolic profiling in orthopaedics is fast evolving with many metabolites already identified in a variety of pathologies. However, these results need to be interpreted with caution due to the presence of multiple confounding factors in many of the studies. Future research should include largescale epidemiological metabolic profiling studies incorporating various confounding factors with appropriate statistical analysis to account for multiple testing of the data. Cite this article: Bone Joint Res. 2020;9(3):108–119.
Chromatic confocal displacement sensing at oblique incidence angles
Authors: Berkovic G. , Zilberman S. , Shafir E. , Rubin D.
Published: March 2020

A commercial chromatic confocal displacement sensor, designed for probing a target at normal incidence, is adapted to probe reflective targets at an oblique incidence angle. The sensor is modified by positioning two low-cost optical elements—a collimating lens and a retro-reflector—in the reflection plane.
Defect characterization of AlInAsSb digital alloy avalanche photodetectors with low frequency noise spectroscopy
Authors: Zhang Ningtao , Jones Andrew H. , Deng Zhuo , Chen Baile
Published: March 2020

An avalanche photodetector (APD) based on the AlxIn1-xAsySb1-y digital alloy materials system has recently attracted extensive attention due to its extremely low excess noise. Device defects are a critical factor limiting the performance of APDs. In this work, we use low frequency noise spectroscopy (LFNS) to characterize the property of the defects in AlxIn1-xAsySb1-y APDs grown by molecular beam epitaxy (MBE) using the digital alloy technique. Based on low frequency noise spectroscopy results carried out before and after device oxidation, two surface defects and one bulk defect have been identified, which could provide useful information for the future optimization the material growth and device fabrication processes.
Lattice-dependent spin Hall effect of light in a Weyl semimetal
Authors: Liu Shuoqing , Shou Yichang , Zhou Xiang , Cheng Wangbin , Luo Zhaoming
Published: March 2020

We systematically study the lattice-dependent spin Hall effect of light (SHEL) in a Weyl semimetal (WSM) by considering left-handed polarization of the incident beam, and propose a new simple method to sense the lattice spacing precisely. It is revealed that the lattice spacing plays as essential a role as the Weyl points separation in the influences on the SHEL, and the variations of SHEL shifts are closely related to the real part of Hall conductivity. Specifically, the SHEL shifts increase to the peak values first and then decrease gradually with the increase of lattice spacing, and a quantitative relationship between the SHEL and the lattice spacing is established. By simulating weak measurement experiments, the lattice-dependent SHEL shifts are amplified and measured in desirable accuracies. Subsequently, we propose a method of precisely sensing the lattice spacing based on the amplified SHEL shifts. These researches provide theoretical basis for manipulating the SHEL in WSMs, and may open the possibility of fabricating the WSM parameter sensors.
Proposal of Brillouin optical time domain collider for dynamic strain measurement
Authors: Zhou Yin , Yan Lianshan , He Haijun , Li Zonglei , Zhang Xinpu , Pan Wei , Luo Bin
Published: March 2020

The dynamic strain sampling rate of Brillouin-based distributed sensors is limited by fiber length. For breaking this limit, a Brillouin optical time domain collider is proposed. A 10-times enhancement on sampling rate is experimentally demonstrated.
Silicon-based Integrated Broadband Wavelength-meter with Low Temperature Sensitivity
Authors: Chen Long , Doerr Chris , Liu Shenghua , Chen Li , Xu Michelle
Published: March 2020

We demonstrated an integrated broadband wavelength-meter with three optical 90-degree mixers, differential photodiodes, and delays of thin TM waveguides, allowing unambiguous wavelength determination over 4 THz with high accuracy and relaxed requirement on temperature control.
Quantum Random Number Generator based on Phase Diffusion in Lasers using an On-chip Tunable SOI Unbalanced Mach-Zehnder Interferometer (uMZI)
Authors: Imran Muhammad , Sorianello Vito , Fresi Francesco , Potì Luca , Romagnoli Marco
Published: March 2020

A 12.5Gb/s QRNG based on phase diffusion in gain switched lasers is demonstrated using a packaged on-chip SOI tunable unbalanced MZI achieving minimum entropy/bit of 5.04 for 8 bit sample passing all NIST randomness tests.
The Enabling Role of Optics and Photonics in the National Quantum Initiative
Authors: Raymer Michael G.
Published: March 2020

Optics and photonics play key roles in integrating university, industry and government research to move quantum information science and technology from theory into practice, including the central areas of quantum sensors, communication systems and computers.
25.78-Gbit/s Burst-mode Receiver for 50G-EPON OLT
Authors: TANAKA Naruto , UMEDA Daisuke , SUGIMOTO Yoshiyuki , FUNADA Tomoyuki , TANAKA Keiji , OGITA Shoichi
Published: March 2020

We report the world's first receiver optical sub-assembly equipped with 25G burstmode TIA which is applicable for 50G-EPON OLT transceiver. We demonstrate its 25G/10G dual-rate burst-mode receiver characteristics.
Neural Network Assisted Geometric Shaping for 800Gbit/s and 1Tbit/s Optical Transmission
Authors: Schaedler Maximilian , Calabrò Stefano , Pittalà Fabio , Böcherer Georg , Kuschnerov Maxim , Bluemm Christian , Pachnicke Stephan
Published: March 2020

End-to-end learning for amplified and unamplified links including binary mapping is proposed to improve the performance of optical coherent systems. 1.0dB and 1.2dB gains are demonstrated on coherent 92GbaudDP-32QAM 800Gb/s and 82GbaudDP- 128QAM 1Tb/s measurements, respectively.
K-means assisted adaptively partitioned entropy loading for FBMC/OQAM system
Authors: Chen Xi , Yan Shuangyi , Tang Ming , Fu Songnian , Liu Deming , Simeonidou Dimitra
Published: March 2020

We adopted K-means clustering to efficiently partition the subcarriers to reduce the complexity of PS-QAM on FBMC/OQAM system using KK receiver. The net data rate of 100 Gb/s is achieved after 125 km transmission.
Phase Noise Spectral Properties Across Individual Comb Lines in Quantum-Dot Mode-Locked Lasers
Authors: AL-QADI Mustafa , O’Sullivan Maurice , Xie Chongjin , Hui Rongqing
Published: March 2020

We study phase-noise spectral properties of comb lines from a QD-MLL, show that their large linewidth variability attributes to the low-frequency phase variations, and has minimal effect on coherent system performance at practical symbol rates.
Narrowband and Low-Noise Brillouin Amplification for Coherent Communications
Authors: Pelusi Mark , Inoue Takashi , Namiki Shu
Published: March 2020

Advantages of Brillouin amplification for phase noise sensitive 64-QAM coherent communications are described. The limits of narrowband gain enhancing the carrier-to-noise ratio of noisy pilot tones for high performance optical signal carrier recovery are shown.
Experimental Demonstration of an Optical Second-Order Volterra Nonlinear Filter using Wave Mixing and Delays to Equalize a 20-Gbaud 4-APSK Channel
Authors: Zou Kaiheng , Liao Peicheng , Zhou Huibin , Fallahpour Ahmad , Minoofar Amir , Almaiman Ahmed , Alishahi Fatemeh , Tur Moshe , Willner Alan E.
Published: March 2020

We demonstrate an optical second-order Volterra filter using wave mixing and delays. We measure the frequency response and perform the compensation of a nonlinearly distorted 20-Gbaud 4-APSK signal with BER reduction from 8.2×10−3 to 3.2×10−3.
Compensation of SOA Nonlinear Distortions by Mid-stage Optical Phase Conjugation
Authors: Sobhanan Aneesh , Pelusi Mark , Inoue Takashi , Venkitesh Deepa , Namiki Shu
Published: March 2020

We investigate optical phase conjugation for compensating nonlinear distortions due to carrier dynamics in semiconductor optical amplifiers. Experiments with WDM-3×12 Gbaud 16-QAM signals show the ability to outperform a single device by 2 dB average Q2-factor improvement.
Circumventing LoS Blocking in Beam-Steered Optical-Wireless Systems with Real-time Tracking and Handover
Authors: Mekonnen Ketema , Pham Quan , Huijskens Frans , Tangdiongga Eduward , Mefleh Ali , Koonen Ton
Published: March 2020

This paper demonstrates a real-time user tracking and handover mechanism for indoor ultrahigh-speed beam-steered optical-wireless systems implementing a low-cost camera. This allows us to tackle LoS blocking by switching to a secondary beam-steering device automatically.
Multi-User Localization and Upstream Signaling for Indoor OWC System using a Camera Technology
Authors: Pham N.Q. , Mekonnen K.A. , Tangdiongga E. , Mefleh A. , Koonen A.M.J.
Published: March 2020

We present upstream signaling and localization for an indoor beam-steered OWC system using vision-based technology. We demonstrate a 1.2kbps upstream signaling and localization system which enables to identify a large number of users with <0.05° error.
25 Gbit/s silicon based modulators for the 2 µm wavelength band
Authors: Cao Wei , Nedeljkovic Milos , Liu Shenghao , Littlejohns Callum G. , Thomson David J. , Gardes Frederic , Ren Zhengqi , Li Ke , Reed Graham T. , Mashanovich Goran Z.
Published: March 2020

We demonstrate high-speed silicon modulators optimized for operating at the wavelength of 2 µm. The Mach-Zehnder interferometer carrier-depletion modulator has a modulation efficiency (V
π
·L
π
) of 2.89 V·cm at 4 V reverse bias. It operates at a data rate of 25 Gbit/s with an extinction ratio of 6.25 dB.
Taper-less III-V/Si Hybrid MOS Optical Phase Shifter using Ultrathin InP Membrane
Authors: Ohno Shuhei , Li Qiang , Sekine Naoki , Fujikata Junichi , Noguchi Masataka , Takahashi Shigeki , Toprasertpong Kasidit , Takagi Shinichi , Takenaka Mitsuru
Published: March 2020

We present proof-of-concept taper-less III-V/Si hybrid MOS optical phase shifter. An ultrathin InP membrane enables low insertion loss despite no taper, with keeping high modulation efficiency owing to strong electron confinement at the MOS interface.
High-Speed-Operation of Compact All-Silicon Segmented Mach-Zehnder Modulator Integrated with Passive RC Equalizer for Optical DAC Transmitter
Authors: Sobu Yohei , Tanaka Shinsuke , Tanaka Yu , Akiyama Yuichi , Hoshida Takeshi
Published: March 2020

We experimentally demonstrated 70Gbaud PAM4 and 90Gbaud NRZ operations of all-silicon segmented modulator for optical DAC transmitter. Monolithic integration of MIM capacitor enabled broad EO bandwidth of 43.9GHz and small footprint of 300×60μm2.
Ultra-miniaturized Endoscopes with Multi-Core Fibers
Authors: Andresen Esben Ravn , Sivankutty Siddharth , Tsvirkun Viktor , Baudelle Karen , Vanvincq Olivier , Bouwmans Géraud , Rigneault Hervé
Published: March 2020

We take stock of the progress made into developing fiber-optic ultra-thin endoscopes assisted by wave front shaping. We focus on multi-core fiber-based lensless endoscopes intended for multi-photon imaging. We put the work into perspective and outline remaining challenges.
A MMW Coordinate Multi-Point Transmission System for 5G Mobile Fronthaul Networks based on a Polarization-Tracking-Free PDM-RoF Mechanism
Authors: Yan Jhih-Heng , Huang Jian-Kai , Lin Yu-Yang , Hsu Jin-Wei , Feng Kai-Ming
Published: March 2020

A PDM-RoF mechanism is firstly experimentally demonstrated for MMW coordinate multi-point transmission system with a polarization-track-free RAU design. Without additional latency for PDM demultiplexing, we evaluate various coordinate multi-point joint transmission scenarios.
Evaluation of the Flexibility of Switching Node Architectures for Spaced Division Multiplexed Elastic Optical Network
Authors: Ding Sicong , Yin Shan , Zhang Zhan , Huang Shanguo
Published: March 2020

We present a flexibility model for quantitatively evaluating switching node architectures in terms of switching strategies, function and required components in SDM-EON, revealing designs with the most switching flexibility.
Capacity Limits of C+L Metro Transport Networks Exploiting Dual-Band Node Architectures
Authors: Emmerich Robert , Eira António , Costa Nelson , Berenguer Pablo Wilke , Schubert Colja , Fischer Johannes Karl , Pedro João
Published: March 2020

We investigate capacity upgrade of metro networks using differentiated node architectures for C+L-bands. The combination of experimental results and network simulations highlights scenarios where low-cost unamplified L-band extensions can be leveraged for maximum capacity.
A DFB-LD-based photonic neuromorphic network for spatiotemporal pattern recognition
Authors: Ma Bowen , Chen Jianping , Zou Weiwen
Published: March 2020

We present a photonic neuromorphic network using DFB-LDs for spatiotemporal pattern recognition. Complete input patterns are investigated theoretically and experimentally. The output peak powers decrease with the difference between the target pattern and other patterns.
Real-time Operation of Silicon Photonic Neurons
Authors: de Lima Thomas Ferreira , Huang Chaoran , Bilodeau Simon , Tait Alexander N. , Peng Hsuan-Tung , Ma Philip Y. , Blow Eric C. , Shastri Bhavin J. , Prucnal Paul
Published: March 2020

In this paper, we use standard silicon-photonic components in order to implement a neuromorphic circuit with two neurons. The network exhibits reconfigurable weights and nonlinear transfer functions, enabling high-bandwidth analog signal processing tasks.
Development of Next Generation Data Communication VCSELs
Authors: Giovane Laura M. , Wang Jingyi , Murty M.V. Ramana , Harren Ann Lehman , Cheng An-Nien , Dolfi David , Feng Zheng-Wen , Leong Nelvin , Sridhara Aaditya , Taslim Sumitro-Joyo , Chu Jason
Published: March 2020

This paper reviews the advancement in VCSEL technology at Broadcom to support the next generation of 850nm multi-mode data communication links at channel bit rates beyond 100Gb/s.
Advances in Deep Learning for Digital Signal Processing in Coherent Optical Modems
Authors: Kuschnerov Maxim , Schaedler Maximilian , Bluemm Christian , Calabro Stefano
Published: March 2020

We analyze the advances of deep learning in optical coherent modems on the physical layer with respect to modulation design, equalization and signal detection and give an outlook on a combined control and physical layer optimization using neural networks.
Workshop on Machine Learning for Optical Communication Systems: a summary
Authors: Gordon Josh , Battou Abdella , Kilper Dan
Published: March 2020

A summary of a public workshop on machine learning for optical Communication systems held on August 2nd 2019, by the Communications Technology Laboratory in cooperation with the Information Technology Laboratory at NIST in Boulder, CO.
High-resolution Microwave Photonics Using Strong On-chip Brillouin Scattering
Authors: Choudhary Amol
Published: March 2020

Processing of microwave signals with resolution as low as 10 MHz is enabled by integrated Brillouin scattering with gain >50dB. We discuss reconfigurable filters, delay lines and phase shifters and also focus on system performance.
Adaptive Microwave Photonic Spectral Shaper for RF Response Tailoring
Authors: Liu Qidi , Fok Mable P.
Published: March 2020

A photonic-enabled fully-programmable RF spectral shaper capable of point-by-point precise manipulation of wideband RF spectrum with 30-MHz resolution is experimentally demonstrated. Over 10 spectral-control points are achieved with the optimized spectral decomposition and reconstruction algorithm.
LiFi Experiments in a Hospital
Authors: Mana Sreelal Maravanchery , Hellwig Peter , Hilt Jonas , Bober Kai Lennert , Hirmanova Volker JungnickelKlara , Chvojka Petr , Janca Radek , Zvanovec Stanislav
Published: March 2020

We present LiFi channel measurements in a neurosurgery room of Motol University Hospital in Prague. Individual channels are combined into a virtual multiuser MIMO link. We report achievable data rates for different LiFi transmission schemes.
Signal-Signal Beat Noise Mitigation by Square Root Processing of the Detected Photocurrent
Authors: Zhang Qiulin , Shu Chester
Published: March 2020

The signal-signal beat noise mitigation performances of the original received signal, the square root processed signal, and the Kramers-Kronig processed signal are experimentally compared in a 110 Gbit/s probabilistically-shaped 64 QAM direct detection system.
Multilevel Coding with Flexible Probabilistic Shaping for Rate-Adaptive and Low-Power Optical Communications
Authors: Yoshida Tsuyoshi , Karlsson Magnus , Agrell Erik
Published: March 2020

A novel multilevel coded modulation scheme with probabilistic shaping is presented. It can reduce the power consumption up to 9 times compared with uniform signaling in the regime of typical hard-decision FEC thresholds.
OpenConfig-extension for VLAN-based end-to-end network slicing over optical networks
Authors: Muqaddas A. S. , Giorgetti A. , Tessinari R. S. , Diallo T. , Sgambelluri A. , Nejabati R. , Simeonidou D.
Published: March 2020

We demonstrate end-to-end VLAN-based network slicing over optical networks using ONOS, based on extended OpenConfig model for hybrid packet-optical terminal devices. Validation is performed by end-to-end interconnected VNFs supporting video streaming use case.
Remote Control of a Robot Rover Combining 5G, AI, and GPU Image Processing at the Edge
Authors: Civerchia F. , Giannone F. , Kondepu K. , Castoldi P. , Valcarenghi L. , Bragagnini A. , Gatti F. , Napolitano A. , Borromeo Justine Cris
Published: March 2020

The demo shows the effectiveness of a low latency remote control based on 5G and image processing at the edge exploiting artificial intelligence and GPUs to make a robot rover slalom between posts.
OpenROADM-controlled White Box encompassing Silicon Photonics Integrated Reconfigurable Switch Matrix
Authors: Sgambelluri Andrea , Velha Philippe , Oton Claudio J. , Giorgetti Alessio , D’Errico Antonio , Stracca Stefano , Cugini Filippo
Published: March 2020

A fully packaged photonic integrated switch matrix including 1398 circuit elements interconnected in a 3-D stack is controlled through OpenROADM NETCONF/YANG Agent and experimentally validated in an ONOS-based SDN testbed encompassing OpenConfig-driven 100G pol-mux transponders.
Physical-Layer Awareness: GNPy and ONOS for End-to-End Circuits in Disaggregated Networks
Authors: Kundrát Jan , Campanella Andrea , Le Rouzic Esther , Ferrari Alessio , Havliš Ondřej , Hažlinský Michal , Grammel Gert , Galimberti Gabriele , Curri Vittorio
Published: March 2020

This demo shows the automatic end-to-end path provisioning over a multi-vendor fully disaggregated Open Line System by Czech Light using the GNPy QoT estimator and Cassini transceiver by the Telecom Infra Project integrated with ONOS.
Flexible Optical Network Enabled Proactive Cross-layer Restructuring for 5G/B5G Backhaul Network with Machine Learning Engine
Authors: Gu Rentao , Qu Yongyao , Lian Meng , Li Hongbiao , Wang Zihao , Zhu Yinan , Guo Qize , Yang Jianjun , Wang Dajiang , Ji Yuefeng
Published: March 2020

It demonstrates a flexible optical network enabled “Network Restructuring as Traffic Changes” for 5G/B5G backhaul network, which realizes proactive cross-layer network generation and mitigation-based network recovery, powered by cognitive enhancement and decision deduction.
Demonstration of Monitoring and Data Analytics-triggered reconfiguration in partially disaggregated optical networks
Authors: Gifre Ll. , Boitier F. , Delezoide C. , Ruiz M. , Buffa M. , Morea A. , Casellas R. , Velasco L. , Layec P.
Published: March 2020

We demonstrate a novel agent for optical disaggregated optical networks. When the Monitoring and Data Analytics detects a degradation, it recommends the SDN controller to trigger a network reconfiguration computed by a novel planning tool.
Automatic Resource Mapping Using Functional Block Based Disaggregation Model for ROADM Networks
Authors: Ishii Kiyo , Xu Sugang , Yoshikane Noboru , Takefusa Atsuko , Yanagimachi Shigeyuki , Hoshida Takeshi , Shiomoto Kohei , Kudoh Tomohiro , Tsuritani Takehiro , Awaji Yoshinari , Namiki Shu
Published: March 2020

Automated mapping of real hardware composition onto a ROADM-based model is demonstrated. The functional-block-based model precisely describing the physical layer structures can act as a hardware abstraction layer for more abstracted models like OpenROADM.
Demonstration of Software-Defined Packet-Optical Network Emulation with Mininet-Optical and ONOS
Authors: Lantz Bob , Díaz-Montiel Alan A. , Yu Jiakai , Rios Christian , Ruffini Marco , Kilper Dan
Published: March 2020

We demonstrate practical software emulation of a software-defined, packet-optical network. Our emulator, Mininet-Optical, models the physical, data plane and control plane behavior, under control of the ONOS SDN controller.
Power efficient all-fiberized 12-core erbium/ytterbium doped optical amplifier
Authors: Mélin Gilles , Kerampran Romain , Monteville Achille , Bordais Sylvain , Robin Thierry , Landais David , Lebreton Aurélien , Jaouën Yves , Taunay Thierry
Published: March 2020

20dB gain in C-band with only 5.3W of pump is achieved with an all-fiberized 12-core Er/Yb doped fiber amplifier. This result is a first step towards SDM transmission including power efficient amplifiers and ROADM.
Spatial Mode Dispersion Control in a Coupled MCF using High Density Cabling Parameters
Authors: Yamada Yusuke , Sakamoto Taiji , Wada Masaki , Nozoe Saki , Sagae Yuto , Yamashita Yoko , Izumita Hisashi , Nakajima Kazuhide , Tanioka Hiroaki
Published: March 2020

Spatial-mode dispersion (SMD) of a coupled multi-core fiber is controlled with cabling parameters for the first time. An SMD coefficient of 1.5 ps/√km is achieved by optimizing the bundle pitch and tension in the cable.
Towards Intelligent Optical Networks: The Role of Intellectual Property
Authors: Gäde Sebastian , Borsier Céline , Ribbe Åsa
Published: March 2020

An overview of worldwide patenting activity covering machine learning and artificial intelligence in the field of optical communication is presented. The results emphasize a worldwide growing market offering benefits for both providers and customers.
30 Gbaud 128 QAM SSB Direct Detection Transmission over 80 km with Clipped Iterative SSBI Cancellation
Authors: Le Son T. , Aref Vahid , Schuh Karsten , Tan Hung N.
Published: March 2020

We demonstrate a novel SSBI cancellation technique operable without digital upsampling for a 30 Gbaud 128 QAM SSB transmission with a record low CSPR of 5 dB, showing 4.6 dB performance improvement compared to the Kramers-Kronig scheme.
Why Data Science and Machine Learning Need Silicon Photonics
Authors: Klenk Benjamin , Dennison Larry
Published: March 2020

Training deep neural networks demands vast amounts of computation, provided by large distributed systems. The increasing demand for bandwidth will exceed the limits of electrical and non-integrated optical signaling and will require integrated optics in the future.
Polarization-diverse silicon photonics WDM receiver with a reduced number of OADMs and balanced group delays
Authors: Nojić Jovana , Schoofs Dominik , Azadeh Saeed Sharif , Merget Florian , Witzens Jeremy
Published: March 2020

We experimentally validate a 10-channel polarization diverse WDM receiver with only one ring based add-drop multiplexer per channel and on-chip optical delay lines balancing the two polarization paths for speeds up to 28 Gb/s.
Grating Coupled Laser (GCL) for Si Photonics
Authors: Lin Shiyun , Wang Ding , Khan Ferdous , Chen Jeannie , Nickel Alex , Kim Brian , Matsui Yasuhiro , Young Bruce , Kwakernaak Martin , Carey Glen , Sudo Tsurugi
Published: March 2020

We report a laser with an integrated grating coupler that emits a large ~30 µm mode through its substrate. The GCL allows coupling to a corresponding grating in the Si PIC and insertion of an optical isolator without lenses.
100 Gb/s Real-Time Transmission over a THz Wireless Fiber Extender Using a Digital-Coherent Optical Modem
Authors: Castro Carlos , Elschner Robert , Merkle Thomas , Schubert Colja , Freund Ronald
Published: March 2020

We demonstrate the real-time transmission of a 34-GBd PDM-QPSK signal over two fiber-optic links interconnected by a THz wireless fiber extender at 300 GHz carrier frequency, with joint impairment compensation by a single-carrier DSP.
Baud-Rate Timing Phase Detector for Systems with Severe Bandwidth Limitations
Authors: Stojanović Nebojša , Rahman Talha , Calabrò Stefano , Wei Jinlong , Xie Changsong
Published: March 2020

A novel timing phase detector using one sample per symbol is developed. The phase detector is especially suitable for systems suffering from serious bandwidth limitations. Its superior performance is demonstrated in simulations and experiments.
Experimental Study of Closed-Form GN Model Using Real-Time m-QAM Transceivers with Symbol Rate up to 69 GBd
Authors: Burtsev Sergey , Searcy Steven , Tibuleac Sorin
Published: March 2020

Real-time transceivers were used to evaluate the accuracy of the closed-form GN model for SSMF and NZDSF C-band terrestrial applications with symbol rates from 34 to 69 GBd and modulation formats from QPSK to 64QAM.
Novel Fuseless Optical Fiber Side-Coupler based on Half-Taper for Cladding Pumped EDFAs
Authors: Matte-Breton Charles , Wang Ruohui , Messaddeq Younès , LaRochelle Sophie
Published: March 2020

We present a novel method for optical fiber side-coupler fabrication that does not require to heat the fibers. More than 94% of average coupling efficiency is demonstrated for input pump power ranging from 1.4 W to 20.7 W.
On-chip Optical Isolators
Authors: Mizumoto Tetsuya , Shoji Yuya
Published: March 2020

Magneto-optical phase shift is effective to realize on-chip optical isolators. Optical isolators are fabricated on SOI platforms with isolation ratios of 30 and 16 dB for TM and TE mode input, respectively.
Heterogeneous Co-Integration of BTO/Si and III-V technology on a Silicon Photonics Platform
Authors: Stark Pascal , Eltes Felix , Baumgartner Yannick , Caimi Daniele , Popoff Youri , Meier Norbert , Czornomaz Lukas , Fompeyrine Jean , Offrein Bert , Abel Stefan
Published: March 2020

We demonstrate for the first time the heterogeneous co-integration of Si photonics, BTO/Si for high-speed modulation and III-V materials for photodetection and emission. We show light coupling with losses <0.5 dB between the different functional layers.
Simple and robust QKD system with Qubit4Sync temporal synchronization and the POGNAC polarization encoder
Authors: Agnesi Costantino , Calderaro Luca , Avesani Marco , Stanco Andrea , Foletto Giulio , Zahidy Mujtaba , Scriminich Alessia , Vedovato Francesco , Vallone Giuseppe , Villoresi Paolo
Published: March 2020

Here we present a simple and robust polarization encoded QKD system that performs synchronization, polarization compensation and QKD with the same optical setup without requiring any changes or any additional hardware.
84-GBaud/λ PAM-4 Transmission over 20-km using 4-λ LAN-WDM TOSA and ROSA with MLSE Based on Nonlinear Channel Estimation
Authors: Taniguchi Hiroki , Yamamoto Shuto , Kisaka Yoshiaki , Kanazawa Shigeru , Yoshimatsu Toshihide , Ishikawa Yozo , Mizuno Kazuyo
Published: March 2020

We demonstrate 168-Gbps/λ PAM-4 transmission over 20-km using 4-λ LAN-WDM TOSA and ROSA with BER below the HD-FEC limit under 24-GHz bandwidth limitation and −39.7-ps/nm chromatic dispersion by applying MLSE based on nonlinear channel estimation.
Network control and orchestration in SDM and WDM optical networks
Authors: Muñoz Raul , Yoshikane Noboru , Vilalta Ricard , Casellas Ramon , Martínez Ricardo , Tsuritani Takehiro , Morita Itsuro
Published: March 2020

We present the first SDN-enabled multi-domain multi-layer (WDM/SDM) control architecture for partially disaggregated optical networks with multiple WDM and SDM OLS domains and transponders to provision end-to-end TAPI connectivity services involving spatial and optical channels.
Demonstrating Optically Interconnected Remote Serial and Parallel Memory in Disaggregated Data Centers
Authors: Mishra Vaibhawa , Benjamin Joshua L , Zervas Georgios
Published: March 2020

Remote serial and parallel memory using memory-over-network bridge and optical switched interconnect is demonstrated. Remote memory bandwidth of 93% (HMC) and 66% (DDR4) of the local 3.2 and 3.7 GB/s bandwidth is showcased.
Flexible 360o 5G mmWave small cell coverage through WDM 4x1 Gb/s Fiber Wireless fronthaul and a Si3N4 OADM-assisted massive MIMO Phased Array Antenna
Authors: Ruggeri Eugenio , Tsakyridis Apostolos , Vagionas Christos , Kalfas George , Oldenbeuving Ruud M. , van Dijk Paul W. L. , Roeloffzen Chris G.H. , Leiba Yigal , Pleros Nikos , Miliou Amalia
Published: March 2020

Four Wavelength Division Multiplexed 1Gb/s QAM16 streams are transmitted through 10km fiber, an Optical Add/Drop Multiplexer and a V-band beamsteering antenna with 90° steering, demonstrating the first 5G Fiber-Wireless A-RoF architecture with 360o coverage.
Transmitter Bandwidth Extension Using Optical Time-Interleaving Modulator and Digital Spectral Weaver
Authors: Yamazaki Hiroshi , Nakamura Masanori , Goh Takashi , Hashimoto Toshikazu , Miyamoto Yutaka
Published: March 2020

We generate 150-Gbaud QAM signals by using an optical time-interleaving modulator driven with 38.1-GHz-bandwidth sub-signals. A digital spectral weaver enables generation of arbitrary bandwidth-extended signals with a simple filter-less optical configuration.
Overcoming low-power limitations on optical frequency combs using a micro-ring resonator
Authors: Corcoran Bill , Prayoonyong Chawaphon , Boes Andreas , Xu Xingyuan , Tan Mengxi , Chu Sai T. , Little Brent E. , Morandotti Roberto , Mitchell Arnan , Moss David J.
Published: March 2020

We show that filtering of an optical frequency comb with a high quality-factor ring resonator enables the use of amplified low power combs as a multi-wavelength source. This approach improves effective source OSNR by 10 dB.
Cost-Effective Solution for High-Capacity Unrepeatered Transmission
Authors: Sutili Tiago , Neto Pedro F. P. , Simões Fábio D. , Suzigan Gabriel J. , Figueiredo Rafael C.
Published: March 2020

A cost-effective 310-km SSMF unrepeatered optical link employing off-the-shelf EDFAs, 1st-order DRAs, and a ROPA is experimentally demonstrated. An iterative optimization process enabled a 12.8-Tbps net transmission (37.5-GHz spaced 128 channels × 100 Gbps).
Asymmetrically Arranged 8-core Fibers with Center Core Suitable for Side-view Alignment in Datacenter Networks
Authors: Sasaki Y. , Ozeki M. , Takenaga K. , Aikawa K.
Published: March 2020

Eight-core multicore fiber with the center core and a cladding diameter of 125 μm is designed and fabricated. Side-view alignment with core identification is realized owing to asymmetrically core arrangement for the first time.
Real-Time Demonstration of 500-Gbps/lambda and 600-Gbps/lambda WDM Transmission on Field-Installed Fibers
Authors: Maeda Hideki , Kawahara Hiroki , Saito Kohei , Seki Takeshi , Sasai Takeo , Hamaoka Fukutaro
Published: March 2020

This paper describes recent technical challenges related to the real-time demonstration 500-Gbps/lambda and 600-Gbps/lambda in field experiments conducted on high-capacity optical transport networks. DSP-ASIC integrated real-time optical transponders are utilized.
Saving Energy and Increasing Density in Information Processing Using Photonics
Authors: Miller David A. B.
Published: March 2020

We argue energy and interconnect density in information processing can be improved by orders of magnitude using parallel free-space optical channels inside and between racks, enabled by integrated waveguide photonics, and run synchronously without time-multiplexing.