bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of blood flow restriction exercise on exercise-induced hypoalgesia and endogenous opioid and endocannabinoid mechanisms of pain modulation
Authors: Hughes Luke , Patterson Stephen David
Published: February 2020

This study aimed to investigate and compare the magnitude of exercise-induced hypoalgesia (EIH) with low-intensity blood flow restriction (BFR) resistance exercise (RE) at varying pressures to other intensities of resistance exercise and examine endogenous mechanisms of pain reduction. Twelve individuals performed four experimental trials involving unilateral leg press exercise in a randomized crossover design: low-load RE at 30% of one repetition maximum (1RM), high-load RE (70% 1RM), and BFR-RE (30% 1RM) at a low and high pressure. BFR pressure was prescribed relative to limb occlusion pressure at 40% and 80% for the low- and high-pressure trials. Pressure pain thresholds (PPT) were assessed before and 5 min and 24 h following exercise in exercising and nonexercising muscles. Venous blood samples were collected at the same timepoints to determine plasma concentrations of beta-endorphin and 2-arachidonoylglycerol. High-pressure BFR-RE increased PPTs in the exercising limb to a greater extent than all other trials. Comparable systemic EIH effects were observed with HLRE and both BFR-RE trials. PPTs in the exercising limb remained elevated above baseline at 24 h postexercise following both BFR-RE trials. Postexercise plasma beta-endorphin concentration was elevated during the BFR-RE trials. No changes to 2-arachidonoylglycerol concentration were observed. High pressure BFR-RE causes a greater EIH response in the exercising limb that persists for up to 24 h following exercise. The reduction in pain sensitivity with BFR-RE is partly driven by endogenous opioid production of beta-endorphin. BFR-RE should be investigated as a possible pain-modulation tool in individuals with acute and chronic pain.

NEW & NOTEWORTHY High-pressure blood flow restriction (BFR) causes a greater hypoalgesia response in the exercising limb (48%) compared with light and heavy load resistance exercise (10–34%). Performing light load resistance exercise with BFR causes systemic hypoalgesia comparable with heavy load resistance exercise (10–18%). BFR resistance exercise prolonged the exercise-induced hypoalgesia response for 24 h in the exercising limb (15% and 24%, respectively). Activation of endogenous opioid production and a conditioned pain modulation effect partly mediate the relationship between exercise and hypoalgesia.
Damage Detection Applied to a Full-Scale Steel Bridge Using Temporal Moments
Authors: Svendsen Bjørn T. , Frøseth Gunnstein T. , Rönnquist Anders
Published: February 2020

The most common damages in existing highway and railway steel bridges are related to fatigue and are, as reported in the literature, found in the structural system of the bridge deck. This paper proposes a methodology for detecting damaged joint connections in existing steel bridges to improve the quality of bridge inspections. The methodology combines the use of temporal moments from response measurements with an appropriate instrumentation setup. Damaged joint connections are identified by comparing statistical parameters based on temporal moments to a baseline, where the baseline data are established from statistical parameters evaluated for all considered joint connections. Localization of damaged joint connections is performed by utilizing the instrumentation setup. The feasibility of the proposed methodology is demonstrated through an experimental study on a full-scale steel riveted truss bridge with two known damages below the bridge deck, where both damages are identified and localized. The proposed methodology can improve the identification of critical structural damage during bridge inspections and is applicable to open-deck steel bridges.
A Novel Approach for Optimizing the Supply Chain: A Heuristic-Based Hybrid Algorithm
Authors: Kocaoglu Yasemin , Cakmak Emre , Kocaoglu Batuhan , Taskin Gumus Alev
Published: February 2020

Managing the distribution of goods is a vital operation for many companies. A successful distribution system requires an effective distribution strategy selection and optimum route planning at the right time and minimum cost. Furthermore, customer’s demand and location can vary from order to order. In this situation, a mixed delivery system is a good solution for it and allows the use of different strategies together to decrease delivery costs. Although the “distribution strategy selection” is a critical issue for companies, there are only a few studies that focus on the mixed delivery network problem. There is a need to propose an efficient solution for the mixed delivery problem to guide researchers and practitioners. This paper develops a new “modified” savings-based genetic algorithm which is named “distribution strategy selection and vehicle routing hybrid algorithm (DSSVRHA).” Our new algorithm aims to contribute to the literature a new hybrid solution to solve a mixed delivery network problem that includes three delivery modes: “direct shipment,” “milk run,” and “cross-docking” efficiently. It decides the appropriate distribution strategy and also optimal routes using a heterogeneous fleet of vehicles at minimum cost. The results of the hybrid algorithm are compared with the results of the optimization model. And the performance of the hybrid algorithm is validated with statistical analysis. The computational results reveal that our developed algorithm provides a good solution for reducing the supply chain distribution costs and computational time.
Mine Pressure Behavior Characteristics and Control Methods of a Reused Entry that Was Formed by Roof Cutting: A Case Study
Authors: Wang Yajun , Wang Haosen , He Manchao , Wang Qi , Qiao Yafei , Yang Jun
Published: February 2020

Noncoal pillar mining with automatic formation of a roadway is a new coal mining method that is tailored to improve the coal resource recovery rate and reduce the investment in roadway tunneling. Using this proposed method, a reuse entry is formed by roof cutting instead of tunneling. In this paper, the S1201-II working face of the Ningtiaota Coal Mine was used as a case study. The stress distribution of surrounding rock and the roof deformation characteristics of the reused entry during the mining process of the second working face were studied through FLAC3D numerical simulations combined with field measurements. The results indicate that the zone close to the reused entry led to higher stress in advance. If this stress is superimposed with the lateral pressure of the adjacent mined working face, it will be more difficult to maintain the reused entry. In the engineering case study described here, the reused entry created a stress increase zone and a severe deformation zone in the range of 0–80 m in front of the working face, and its range was approximately 37.5% larger than an ordinary entry. The stress peak in the stress increase zone increased by approximately 34.7% over that of an ordinary entry. The maximum amount of deformation within the severe deformation zone increased by 94.4% over that of an ordinary entry. To properly control the surrounding rock stress and deformation of the reused entry, a dynamic pressure bearing support in front of the working face with adaptability to the large roof deformation and high support strength is proposed here. Field application results showed that the final roof deformation with the dynamic pressure bearing support can be satisfactorily controlled within 110∼130 mm. These findings can provide a reference for researchers and field engineering technicians when engaging in the support work of reused entry.
Long-Lasting Follow-Up with Low-Dose Steroid in an 18-Year-Old Male with Rosai–Dorfman Disease
Authors: Karakuş Volkan , Dere Yelda Morgül , Soysal Dilek Ersil
Published: February 2020

Rosai–Dorfman disease (RDD) is a rare and benign pathology of sinus histiocytosis of unknown etiology. Lymphadenopathy is the predominant clinical manifestation, but diverse organs can also be affected. Histological features involve S-100+ histiocytes with characteristic nuclear features within the enlarged sinusoids of the lymph nodes. The clinical course is unpredictable, but is often benign with spontaneous resolution of disease in most patients. We report a patient with bilateral massive enlargement of cervical, axillary, and inguinal lymph nodes, moderately enlarged spleen, and a weight loss of 15 kg. Excisional biopsy from the cervical lymph node showed that the dilated sinusoids were infiltrated by lymphocytes, plasma cells, and large histiocytes with CD 68 and S-100 protein positive. Due to the slow progression of the disease, oral prednisolone with a body weight of 1 mg/kg was started in March 2016. The steroid dosage has been adjusted many times during the clinical follow-up. After 33 months, steroid treatment resulted in partial shrinkage of lymph nodes, the spleen returned to its normal size, and the patient gained weight. After 38 months of follow-up, no systemic symptoms, sign, or extranodal involvement were detected, and the patient continued with low-dose steroid treatment.
Acute Appendicitis in Patients with Kartagener Syndrome
Authors: Cembraneli Pedro Nogarotto , Ambrogi Gabriel , Cavalcante Julia Brasileiro de Faria , Raphe Raphael , Luporini Rafael Luís
Published: February 2020

Situs inversus totalis is a congenital syndrome characterized by a total left-right transposition of all abdominal and thoracic organs. It may be associated with chronic respiratory conditions such as sinusitis and bronchiectasis, composing the Kartagener syndrome. If not detected, this condition may compromise the early diagnosis of surgical emergencies such as cholecystitis and appendicitis. A rare case of appendicitis in a patient with Kartagener syndrome is here reported.
Effortful Control – A Transdiagnostic Dimension Underlying Internalizing and Externalizing Psychopathology
Authors: Santens Els , Claes Laurence , Dierckx Eva , Dom Geert
Published: February 2020

Effortful control (EC) or self-regulation refers to the ability to regulate behavior, emotion, and cognition. It has been identified as a contributor to both adaptive and adverse outcomes in children, adolescents, and adults and this across many domains. As such, it could be considered as a transdiagnostic dimension underlying internalizing (e.g., mood and anxiety disorders) and externalizing (e.g., substance use disorders, ADHD) psychopathology. We aimed to examine the role of EC throughout the adult psychopathological spectrum by means of a literature search of studies published between 2008 and 2018. Overall, the results point to the role of EC in the development of a broad spectrum of psychiatric diagnosis, reflecting the transdiagnostic characteristic of this construct. This role may be both directly causal or as a mediator factor influencing outcomes of a specific disorder. Early assessment of EC and early interventions to improve EC might help to avoid or decrease the risk of developing psychopathology.
Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease
Authors: Huang Cheng-Kai , Kafert-Kasting Sabine , Thum Thomas
Published: February 2020

RNA modulation has become a promising therapeutic approach for the treatment of several types of disease. The emerging field of noncoding RNA-based therapies has now come to the attention of cardiovascular research, in which it could provide valuable advancements in comparison to current pharmacotherapy such as small molecule drugs or antibodies. In this review, we focus on noncoding RNA-based studies conducted mainly in large-animal models, including pigs, rabbits, dogs, and nonhuman primates. The obstacles and promises of targeting long noncoding RNAs and circRNAs as therapeutic modalities in humans are specifically discussed. We also describe novel ex vivo methods based on human cells and tissues, such as engineered heart tissues and living myocardial slices that could help bridging the gap between in vivo models and clinical applications in the future. Finally, we summarize antisense oligonucleotide drugs that have already been approved by the Food and Drug Administration for targeting mRNAs and discuss the progress of noncoding RNA-based drugs in clinical trials. Additional factors, such as drug chemistry, drug formulations, different routes of administration, and the advantages of RNA-based drugs, are also included in the present review. Recently, first therapeutic miRNA-based inhibitory strategies have been tested in heart failure patients as well as healthy volunteers to study effects on wound healing (NCT04045405; NCT03603431). In summary, a combination of novel therapeutic RNA targets, large-animal models, ex vivo studies with human cells/tissues, and new delivery techniques will likely lead to significant progress in the development of noncoding RNA-based next-generation therapeutics for cardiovascular disease.
Portrait of Artist Shi Wenqing
Authors: Eller Thomas , Malina Roger , Wenqing Shi
Published: February 2020

On further review, the editors of Leonardo journal and the leadership of the International Society for the Arts, Sciences and Technology have rescinded acceptance of this article as it does not fit the editorial focus of our publication. We regret the error.
Did Artapanus Use the Septuagint?
Authors: Hitchcock Jason D.
Published: February 2020

Many contend that the Hellenistic-era author Artapanus employed the LXX translation, albeit in relatively liberal fashion. Departures from LXX narratives are attributed to his literary and apologetic interests. Although he may have relied upon a combination of oral and written sources, most scholars presuppose his primary reliance upon the LXX. This paper evaluates arguments for Artapanus’s use of the LXX, highlighting the paucity of decisive verbal links and weakness of other proposed linguistic correspondences, and attributing the emergence of similar Greek naming conventions between Artapanus and the LXX to the shared Egyptian provenance. These findings challenge the prevailing consensus concerning Artapanus’s source for Jewish traditions.
Revision of the Melanogaster jaroslavensis group (Diptera: Syrphidae), with description of a new species from Afghanistan
Authors: POPOV GRIGORY V. , PROKHOROV ALEXEY V.  , KUSTOV SEMEN Yu. 
Published: February 2020

Within the genus Melanogaster Rondani, 1857, the group of species characterized by their yellow wing base was named as M. jaroslavensis group and revised for the first time. Redescriptions of M. jaroslavensis (Stackelberg, 1922), M. kirgisorum (Stackelberg, 1952), and M. tadzhikorum (Stackelberg, 1952) are provided. A new species of the M. jaroslavensis group, Melanogaster raccoon sp. nov., from Afghanistan, is described. The male of this new species differs from those of other known Melanogaster species by the following combination of characters: yellowish wing base, pale body pile, without dark pile, almost flat face, and surstyli short and emarginated apically in ventral view. Females of M. raccoon sp. nov. differ from those of any other Melanogaster species by a combination of yellowish wing base and frons without transverse furrows. An identification key to the species of the M. jaroslavensis group is presented.
TWO NEW SPECIES AND A NEW RECORD OF DACUS FABRICIUS (DIPTERA: TEPHRITIDAE) FROM INDIA
Authors: DAVID K. J. , SACHIN K. , HANCOCK D. L.
Published: February 2020

Two new species of the genus Dacus Fabricius, namely D. (Mellesis) jacobi David & Sachin and D. (Mellesis) viraktamathi David & Hancock of tribe Dacini are described from India. Dacus (Mellesis) maculipterus White is recorded for the first time from India. An updated key to species of genus Dacus from India, Bhutan and Sri Lanka is also provided.
A new species of Stolephorus (Clupeiformes: Engraulidae) from the Bay of Bengal, India
Authors: GANGAN SHARDUL S , PAVAN-KUMAR ANNAM , JAHAGEERDAR SHRINIVAS , JAISWAR A. K.
Published: February 2020

A new fish species, Stolephorus tamilensis sp. nov., is described from the East coast of India. The major distinguishing characters are 5–6 small needle-like pre-pelvic scutes on belly; maxilla tip pointed, reaching to border of operculum, concave and indented in the preoperculum; 25–28 gill rakers on lower lobe of the first branchial arch; dorsal fin without spine; 17–19 anal-fin rays. Moreover, S. tamilensis sp. nov. present higher average genetic divergence values at mitochondrial cytochrome c oxidase subunit I and 16S rDNA loci in comparison with congeners. Also, nucleotide diagnostic characters exclusive to S. tamilensis are identified. Neighbor-joining analysis revealed close relation between S. tamilensis  and S. andhraensis.
The Commercial Consequences of Collective Layoffs: Close the Plant, Lose the Brand?
Authors: Landsman Vardit , Stremersch Stefan
Published: February 2020

This article examines the effects of collective layoff announcements on sales and marketing-mix elasticities, accounting for supply-side constraints. The authors study 205 announcements in the automotive industry using a difference-in-differences model. They find that, following collective layoff announcements, layoff firms experience adverse changes in sales, advertising elasticity, and price elasticity. They explore the moderating role of announcement characteristics on these changes and find that collective layoff announcements by domestic firms and announcements that do not mention a decline in demand as a motive are more likely to be followed by adverse marketing-mix elasticity changes. On average, sales for the layoff firm in the layoff country are 8.7% lower following a collective layoff announcement than their predicted levels absent the announcement. Similarly, advertising elasticity is 9.8% lower and price elasticity is 19.2% higher than absent the announcement. Conversely, layoff firms typically decrease advertising spending in the country where collective layoffs have occurred, yet they do not change prices. These findings are relevant to marketing managers of firms undergoing collective layoffs and to analysts of collective layoff decisions.
Highlighting Effort Versus Talent in Service Employee Performance: Customer Attributions and Responses
Authors: Leung Fine F. , Kim Sara , Tse Caleb H.
Published: February 2020

Firms often attribute their service employees’ competent performance to either dedicated effort or natural talent. However, it is unclear how such practices affect customer evaluations of service employees and customer outcomes. Moreover, prior work has primarily examined attributions of one’s own performance, providing little insight on the impact of attributions of others’ performance. Drawing on research regarding the warmth–competence framework and performance attributions, the current research proposes and finds that consumers expect a more communal-oriented and less exchange-oriented relationship when a service employee’s competent performance is attributed to dedicated effort rather than natural talent, as effort (vs. talent) attribution leads consumers to perceive the employee as warmer. The authors further propose customer helping behaviors as downstream consequences of relationship expectations, finding that effort (vs. talent) attribution is more likely to induce customers’ word-of-mouth and idea provision behaviors. The findings enrich existing literature by identifying performance attributions as a managerially meaningful antecedent of relationship expectations and offer practical guidance on how marketers can influence consumers’ relationship expectations and helping behaviors.
Varieties of Urbanism: A Comparative View of Inequality and the Dual Dimensions of Metropolitan Fragmentation
Authors: Freemark Yonah , Steil Justin , Thelen Kathleen
Published: February 2020

A large literature on urban politics documents the connection between metropolitan fragmentation and inequality. This article situates the United States comparatively to explore the structural features of local governance that underpin this connection. Examining five metropolitan areas in North America and Europe, the article identifies two distinct dimensions of fragmentation: (a) fragmentation through jurisdictional proliferation (dividing regions into increasing numbers of governments) and (b) fragmentation through resource hoarding (via exclusion, municipal parochialism, and fiscal competition). This research reveals how distinctive the United States is in the ways it combines institutional arrangements that facilitate metropolitan fragmentation (through jurisdictional proliferation) and those that reward such fragmentation (through resource-hoarding opportunities). Non-US cases furnish examples of policies that reduce jurisdictional proliferation or remove resource-hoarding opportunities. Mitigating the inequality-inducing effects of fragmentation is possible, but policies must be designed with an identification of the specific aspects of local governance structures that fuel inequality in the first place.
Book review: Yogesh Snehi, Spatializing Popular Sufi Shrines in India: Dreams, Memories, Territoriality
Authors: Vasavi A. R.
Published: February 2020

Yogesh Snehi, Spatializing Popular Sufi Shrines in India: Dreams, Memories, Territoriality. London: Routledge, 2019, 256 pp., ₹995 (hardback). ISBN: 978-0-367-37499-0.
Book review: Paramjit S. Judge, Making of Modern India: Sociological Explorations into Postcolonial Indian Modernity
Authors: Sahay Gaurang R.
Published: February 2020

Paramjit S. Judge, Making of Modern India: Sociological Explorations into Postcolonial Indian Modernity. Jaipur: Rawat Publications, 2019, 239 pp., ₹995 (hardback). ISBN: 978-81-316-1008-4.
István Szabó
Authors: Petrie Graham
Published: February 2020

This article deals with post-1960 Hungarian cinema, particularly through the work of one of its most prominent figures, István Szabó.
The Russian Revolution as fantastic synaesthetic event (Sigizmund Krzhizhanovskii and Vladimir Sharov)
Authors: Emerson Caryl
Published: February 2020

This essay introduces two experimental Russian writers, Sigizmund Krzhizhanovskii (1887–1950) from the Soviet era and Vladimir Sharov (1952–2018) from the post-Soviet period, through their depictions of the Revolution and Civil War. Both attempt to ‘estrange’ this horrific period by drawing on unusual sensory input – smells, for example, or textures and densities – thus allowing the reader to bypass the brute political event in favour of its ‘feel’. The analysed texts include an olfactory history of the revolutionary years inspired by the composer Alexander Skriabin from Sharov’s 1993 novel Before & During, and a dream-sequence involving a toad in Krzhizhanovskii’s fantastic parable from 1931, ‘Bridge over the Styx’. The resulting narratives are, of course, still moral and political tales, but grounded more universally.
Against Such Things There is No Law: Evangelical College Students’ Perceptions of the Fruit of the Spirit as Primarily Gendered
Authors: Rice Diana R.
Published: February 2020

Although it is clear in Scripture that Christian spiritual growth includes the development of godly characteristics like those outlined in Galatians 5, anecdotal evidence suggests that people view some spiritual characteristics as primarily feminine in nature. In a series of three studies, evangelical Christian college students evaluated gender stereotypes interspersed with characteristics commonly described as “the Fruit of the Spirit” from Galatians 5. Despite a variety of methodological approaches, students consistently rated the Fruit of the Spirit as primarily descriptive of women. Implications of these results for broader issues of gender stereotyping and Christian life are discussed.
Nonlinear Viscoelastic Response of Crumb Rubber Modified Asphalt Binder Under Large Strains
Authors: Gulzar Saqib , Underwood B. Shane
Published: February 2020

Agencies have been increasing their use of polymer modified asphalt binders in recent years to address performance issues and lengthen the useful life of their pavements. When deployed these materials likely experience strain levels exceeding their linear viscoelastic (LVE) limits. The same situation exists in non-polymer modified asphalt binders as well, but the effect may be more pronounced in polymer modified systems because of their bi-phasic nature. In this study, terminally blended crumb rubber (CR-TB) modified asphalt is studied to understand and quantify the nonlinear viscoelastic response under large strains. The CR-TB binders are extensively used in pavements subjected to high vehicular loads and extreme climatic conditions; thereby, their response under large strains becomes more critical. The current standard characterization techniques are based on LVE response using small amplitude oscillatory shear rheology only and do not consider the behavior of binders under large strains. In this study, large amplitude oscillatory shear (LAOS) rheology is used as a framework to more thoroughly investigate the complete response of the CR-TB modified asphalt binder under large strains at 30°C, 40°C, 50°C, and 60°C and at the frequencies of 0.5, 1, and 5 Hz. The LAOS response is analyzed using Fourier-transform rheology and the orthogonal stress decomposition method involving Chebyshev polynomial representation. It is found that nonlinearity manifests greatly in this study material as strain levels increase and frequencies decrease. The relative nonlinearity increases with increasing strain amplitude and is more significant towards lower end of the tested temperature range. The CR-TB binder shows strain-stiffening/softening and shear-thinning/thickening behavior depending upon a specific temperature, strain level, and frequency.
Geogrid Stabilization of Unbound Aggregates Evaluated Through Bender Element Shear Wave Measurement in Repeated Load Triaxial Testing
Authors: Kang Mingu , Kim Joon Han , Qamhia Issam I. A. , Tutumluer Erol , Wayne Mark H.
Published: February 2020

This paper describes the use of the bender element (BE) shear wave measurement technology for quantifying the effectiveness of geogrid stabilization of unbound aggregate materials with improved mechanical properties from repeated load triaxial testing. Crushed stone aggregate specimens were prepared with three different gradations, that is, upper bound (UB), mid-range engineered (ENG), and lower bound, according to the dense graded base course gradation specification in Illinois. The specimens were compacted at modified Proctor maximum dry densities and optimum moisture contents. Two geogrids with different triaxial aperture sizes were placed at specimen mid-height, and unstabilized specimens with no geogrid were also prepared for comparison. To measure shear wave velocity, three BE pairs were placed at different heights above geogrid. Repeated load triaxial tests were conducted following the AASHTO T307 standard resilient modulus test procedure, while shear wave velocity was measured from the installed BE pairs. After initial specimen conditioning, and at low, intermediate, and high applied stress states, both the resilient moduli and accumulated permanent strains were determined to relate to the geogrid local stiffening effects in the specimens quantified by the measured shear wave velocities. The resilient modulus and shear wave velocity trends exhibited a directly proportional relationship, whereas permanent strain and shear wave velocity values were inversely related. The enhancement ratios calculated for the geogrid stabilized over the unstabilized specimens showed significant improvements in mechanical behavior for the UB and ENG gradations, and a maximum enhancement was achieved for the engineered gradation specimens stabilized with the smaller aperture geogrid.
Discipleship through Literature: A Case Study of the Selamat Series in Indonesia
Authors: Sidjabat Binsen Samuel
Published: February 2020

This article emphasizes that discipleship is a fundamental task of the church. To guide Christians, particularly adults, for discipleship, literature is needed in the form of easy-to-understand reading materials. Andar Ismail, Christian educator in Indonesia, guides adult Christians to understand Jesus Christ through devotional books called the Selamat Series. Although readers find the works meaningful, they need to be used with a critical mind and attitude.
Imaging Ballistic Injuries
Authors: Ditkofsky Noah G. , Maresky Hillel , Mathur Shobhit
Published: February 2020

Here in Canada, we often think of gun violence as confined to conflict zones, terrorism, and more of a problem for our southern neighbor. However, in recent years, it has also become a Canadian problem with increased gun violence related to criminal activity presenting in daily practice. Radiologists play a critical role in the evaluation of ballistic trauma and must therefore be familiar with both the common and uncommon patterns of ballistic injury. In this article, we review the mechanisms of ballistic trauma as well as their resultant injury patterns in order to guide image interpretation.
Familial Acute Necrotizing Encephalopathy: Evidence From Next Generation Sequencing of Digenic Inheritance
Authors: Iyer Gayatri , Utage Prashant , Bailur Sarah , Utage Aparna , Srirambhatla Annapurna , Hasan Qurratulain
Published: February 2020

Infection-induced acute encephalopathies (IIAEs) are a group of neurologic disorders caused post infection. They are of 8 types, 6 of which are herpes specific, whereas IIAE3 and IIAE4 can be triggered by infections additional to herpeslike influenza, enterovirus, etc. IIAE3 is also known as acute necrotizing encephalopathy type 1, which is a rare type of encephalopathy that occurs following an infection in infancy or early childhood. Symptoms include fever, cough, congestion, vomiting, and diarrhea followed by seizures, hallucination, ataxia, and abnormal muscle tone, and sometimes it leads to untimely death. Here, we describe a familial case where 3 siblings were clinically diagnosed with acute necrotizing encephalopathy 1. Genetic testing revealed 2 heterozygous variations: RANBP2 c.5249C>G, p.P1750 R, and CPT2 c.365C>T, p.S122F. Variants in RANBP2 and CPT2 have been individually known to be associated with IIAE3 and IIAE4, respectively. Segregation analysis revealed that the RANBP2 variant was inherited from the father and the CPT2 variant from the mother. This case qualifies to be the first of its kind where digenic inheritance (ie, DNA sequence variants in 2 genes are required for the pathogenic phenotypes) appears to cause a lethal class of acute necrotizing encephalopathy.
Haven or Limbo? Neuroscientist Refugees From National Socialism Escape to Illinois
Authors: Zeidman Lawrence A.
Published: February 2020

At least 9 neuroscientists immigrated from Nazi Europe to Illinois to escape tyranny and attempt to re-establish their careers. Some work has been published in print on eponymous neuroscientist Adolf Wallenberg, as well as 2 others but not on Ernst Haase, Frederick Hiller, Erich Liebert, Bruno Volk, Heinz (Henry) von Witzleben, or Gerhard Pisk. Before leaving Germany or Austria, these downtrodden specialists were dismissed from long-held posts sometimes for trumped-up charges, stripped of their financial security, and forced to leave relatives behind. At least 1 left only for personal and political, but not because of racial, reasons. Illinois, in exemplary fashion, welcomed these unfortunate survivors more than many other states because of limited licensing requirements, numerous opportunities at state hospitals, and special internship programs. Some of them successfully continued their research agendas and published, taught neurology students and trainees, and added to the expansion of neurologic care in Illinois or elsewhere, but most of them took years to reacquire the academic rank they lost and never regained their career momentum. These refugees survived and passed on some of their extensive training and expertise to a new generation of neuroscientists in America, but not without significant cost.
The Impact of Health Promotion Interventions on Telomere Length: A Systematic Review
Authors: Qiao Shan , Jiang Yanping , Li Xiaoming
Published: February 2020

Objectives:

The aim of this study was to evaluate the effectiveness of health promotion interventions in delaying telomere shortening (a biomarker for aging).

Data Source:

PubMed, PsychINFO, EMBASE, CINAHL, and Cochrane Library databases.

Study Inclusion and Exclusion Criteria:

Inclusion criteria: (1) empirical studies involving human subjects; (2) health promotion intervention studies including both randomized control trials (RCTs) and non-RCTs.; (3) measured telomere length as an intervention outcome; and (4) were written in English. Exclusion criteria: (1) observational studies without any health promotion intervention practices and (2) did not report intervention effects.

Data Extraction:

Data extraction was performed by two reviewers following the preferred reporting items for systematic reviews and meta-analysis guidelines.

Data Synthesis:

Substantial heterogeneity in intervention type and study design in the included studies precluded a meta-analysis. We conducted a narrative synthesis instead.

Results:

Thirty studies were included in the review, of which 16 were RCTs. One-third of the included studies reported significant intervention impacts in delaying telomere shortening, with relatively consistent significant results emerged from weight-loss interventions and interventions involving multiple lifestyle modification components (eg, diet and exercise). Most of supplement intervention studies observed null effects in telomere length.

Conclusions:

Weight-loss and comprehensive lifestyle intervention strategies show encouraging impacts in delaying telomere shortening. More rigorous studies targeting populations at different age stages through life span are needed.
Tunable-with-energy intense modal interactions induced by geometric nonlinearity
Authors: Mojahed Alireza , Bergman Lawrence A , Vakakis Alexander F
Published: February 2020

Modal interactions are distinct features of nonlinear systems that can be exploited in applications such as vibration and shock mitigation, targeted (irreversible) energy transfers (TET), and acoustic/stress wave tailoring. For such applications, different types of nonlinearities, e.g. hardening, softening, smooth, non-smooth, material or geometric, have been considered. In this work, we examine the geometric nonlinearity resulting from an initially inclined element consisting of a linear spring and a viscous damper connected in parallel, having an initial angle of inclination, [Formula: see text]. Because of its inclined configuration, this element possesses strong (and doubly tunable with respect to [Formula: see text] and energy) geometrically nonlinear stiffness and damping effects, despite the linear constitutive laws governing its constituent components. First, we consider a single-degree-of-freedom linearly grounded oscillator attached to the nonlinear inclined element. Omitting dissipative effects, we investigate the frequency–energy relation of this system by employing the canonical action-angle transformation and show that, depending on the initial angle of inclination and the energy-level, the resulting nonlinearity can be tuned to be softening, hardening or a combination of both. Next, we explore the efficacy of the geometric nonlinearity to induce strong modal interactions by considering a three-degree-of-freedom lightly damped primary system that is weakly coupled to a single-degree-of-freedom lightly damped attachment with the inclined nonlinear element, subjected to impulsive excitation. Varying [Formula: see text] and the input energy, we demonstrate strong modal energy-exchanges between the modes of the primary system and the nonlinear attachment over broad energy-dependent spans of [Formula: see text]. We show that the passive self-adaptiveness of the nonlinear damping and the hardening–softening geometric nonlinearity can induce narrowband or broadband frequency TET, including high-to-low frequency energy transfers. Interestingly, over a definitive range of [Formula: see text], these modal interactions may be limited only between the nonlinear mode of the attachment and the highest-frequency linear mode of the primary system, inducing strong high-frequency targeted energy transfer to the primary system.
Valorization of cassava waste for pullulan production by Aureobasidium pullulans MTCC 1991
Authors: Viveka Ravichandran , Varjani Sunita , Ekambaram Nakkeeran
Published: February 2020

The interest in pullulan produced from industrial wastes has substantially increased due to its industrial applications. The major constraint in pullulan production is expensive and low yield. In this study, attempts were made on the evaluation of media components for maximum pullulan production from Aureobasidium pullulans MTCC 1991 using cassava waste in solid-state fermentation. A statistical approach was scrutinized to evaluate the effects of yeast extract, K2HPO4, (NH4)2SO4, MgSO4⋅7H2O, and NaCl on pullulan production. The optimal conditions eliciting the maximum pullulan yield (6.45 g pullulan/L of culture broth) were found to be 0.6 g/L yeast extract, 3 g/L K2HPO4, 0.2 g/L (NH4)2SO4, 0.3 g/L MgSO4⋅7H2O, and 1 g/L NaCl. The produced pullulan was extracted using the solvent precipitation method and characterized by Fourier transform infrared spectroscopy and proton nuclear magnetic resonance spectroscopy spectroscopic analysis that confirmed pullulan with linear α (1–6) linkage. The results revealed that cassava waste could be used as an effective carbon source for the production of pullulan.
Effects of magnetoelastic loads on free vibration characteristics of the magnetorheological-based sandwich beam
Authors: Rokn-Abadi Mohammad Rayyat , Shahali Pooriya , Haddadpour Hassan
Published: February 2020

In this contribution, we have investigated the effects of magnetoelastic loads on free vibration characteristics of the magnetorheological-based sandwich beam. The considered sandwich beam consists of a magnetorheological core with elastic top and base layers. For these means, the structural governing equations are derived using the Hamilton principle and solved by the finite element method. The results are validated in comparison with the existing results in the literature. The effects of variation in the parameters such as magnetic field intensity and the thickness of the core and top layers on the deviation of the first natural frequency and the corresponding loss factor are studied as well. Finally, in order to provide deep insight, the effects of magnetoelastic loads on the dynamic behavior of the three-layered sandwich beam are examined through a comprehensive survey.
Improving Inquiry Questions to Foster Critical Thinking and Reflective Practice in a Journalism Capstone
Authors: Bowe Brian J. , Kjesrud Roberta , Hemsley Pippa
Published: February 2020

Education researchers have long been interested in helping students develop effective inquiry questions to guide research projects. In this study, students in a journalism senior capstone used writing-studies informed practices such as middle-stakes, iterative writing prompts to enhance metacognition and critical thinking. Using prompts to guide students to periodically revise their inquiry questions and working thesis statements, students showed improvement in their written products as measured through holistic writing assessment measures. Despite measurable improvement, students’ thesis statements were still lackluster, suggesting that programs should develop connected curricula that sequentially scaffold research methods, critical thinking, and writing skills across the major.
Ocular biometrics as a function of age, gender, height, weight, and its association with spherical equivalent in children
Authors: Hashemi Hassan , Pakzad Reza , Khabazkhoob Mehdi , Yekta Abbasali , Emamian Mohammad Hassan , Fotouhi Akbar
Published: February 2020

Purpose:

To determine the distribution of ocular biometric components, including axial length, lens thickness, and vitreous chamber depth, their relationship with personal characteristics, and spherical equivalent refraction after adjusting axial length and vitreous chamber depth for personal characteristics.

Methods:

Among 6- to 12-year-old children, urban subjects were selected using random cluster sampling, and in rural areas, all eligible subjects were considered for enrollment. Ocular biometrics were measured using BioGraph. Data were summarized as mean and 95% confidence intervals. Linear regression was used to investigate the relationships between the study variables.

Results:

Data from 4938 children were analyzed. Mean axial length, lens thickness, and vitreous chamber depth were 23.02 (95% confidence interval: 22.97–23.07) mm, 3.48 (95% confidence interval: 3.47–3.49) mm, and 20.63 (95% confidence interval: 20.59–20.66) mm, respectively. According to the multiple linear regression model, axial length and vitreous chamber depth associated positively with height (β = 0.020, P < 0.001; β = 0.018, P < 0.001, respectively) and inversely with female gender (β = −0.522, P < 0.001; β = −0.386, P < 0.001, respectively). Also lens thickness correlated inversely with age (β = −0.019, P < 0.001) and positively with female gender (β = 0.043, P < 0.001). After adjusting for personal characteristic, spherical equivalent had an inverse relationship with axial length (β = −0.441, P < 0.001) and a positive relationship with lens thickness (β = 0.423, P < 0.001). Among the studied variables, axial length had the strongest association with spherical equivalent (standardized coefficient: −0.39).

Conclusion:

This cross-sectional study showed a general pattern of ocular biometric components. The axial length value was almost similar to European countries, but less than that in the Eastern and Southeast Asian populations. By increasing age, axial length and vitreous chamber depth increased while lens thickness and spherical equivalent decreased. Among all ocular biometric components, axial length was strongest determinant for spherical equivalent.
Gaining Large Coverage With Small Island Pedicle Flaps in Tight Cosmetic Subunits: Taking Advantage of Rotation and Pincer Principles on the Nasal Ala
Authors: Wong Noelle , Kossintseva Irèn
Published: February 2020

Background

Island pedicle flaps (IPFs) are widely used in reconstructive surgery due to their versatility, tissue efficiency, and excellent clinical outcomes. While IPF rotations and ‘pincer flap’ modifications have previously been sparsely described, they are not often discussed in the literature.

Objective

We demonstrate the use of both rotating IPFs and pincer techniques for defects traditionally considered too large for classic IPF design on the nasal ala.

Methods

Forty-four patients underwent alar repair using the rotation or combined rotation with pincer modification to the standard IPF technique from August 2014 to May 2017. Our technique is described and case examples are presented with photographs.

Results

Forty-four patients with an average alar defect size of 1.2 cm underwent repair using rotation only or rotation with pincer modification of the classic IPF approach.

Conclusions

Reconstruction of large defects in small facial cosmetic subunits such as the nasal ala can be performed using principles of both rotating IPFs and the ‘pincer flap’ technique. The degree of rotation is directly related to the length of coverage. Modifications to the flap are straightforward to perform. Using these techniques, larger defects that previously would have been reconstructed using flaps that cross cosmetic boundaries can now be reconstructed within the same cosmetic unit, thus, improving aesthetic outcomes.
A pioneer of psy: The first Ugandan psychiatric nurse and her (different) tale of psychiatry in Uganda
Authors: Vorhölter Julia
Published: February 2020

In Africa, the emergence of a “modern” mental health regime centered on psychiatry is often portrayed as a unidirectional intervention by “the West.” Analyses ranging from medical histories of colonial psychiatry to more recent studies of Global Mental Health focus mostly on the role of external actors and the ways their actions impact(ed) on local populations. Uncritical studies simply reduce the complexity of African therapeutic landscapes to a “treatment gap” and see the introduction of “science-based” mental health approaches as necessary “civilizing” missions. Critical studies emphasize the harms of psychiatric interventions and celebrate local healing practices instead. Both approaches are problematic: they ignore the many interconnections between highly dynamic treatment regimes that cannot be neatly designated as African or western, portray local populations as largely passive, and neglect the multiple ways in which psychiatry has been embraced, adapted, and disrupted by Africans themselves. This article challenges simplistic depictions of “western” psychiatry in Africa by providing a portrait of Rwashana Selina, the first Ugandan psychiatric nurse who—after being sent to the UK in the 1950s for training—became a central figure in Ugandan psychiatry. Based on interview material, I recount her life story and discuss her formative role in the development of psychiatric care in the colonial and postcolonial era. Rwashana's tale of Ugandan psychiatry emphasizes co-operation, mutual acknowledgments and pluralistic leadership and thus breaks with typical images of and dichotomies between white doctors and supposedly inferior African medical staff.
Experimental and numerical investigation of the bending fatigue performance of symmetric and asymmetric polymer gears
Authors: Karthik Pandian A , Gautam Sachin Singh , Senthilvelan S
Published: February 2020

In this work, the bending fatigue strengths of injection-molded symmetric and asymmetric nylon 66 gears were evaluated experimentally, and the results were substantiated using numerical studies. The symmetric (20°/20°) and asymmetric (34°/20° and 20°/34°) configurations were subjected to bending fatigue tests under a load controlled mode. The bending stresses of the symmetric and asymmetric gears were predicted by quasi-static simulations using a commercial finite element analysis software. The form factor ([Formula: see text]) and the stress correction factor ([Formula: see text]) were computed using an adapted ISO method. The 34°/20° configuration exhibited the lowest bending stress and highest bending fatigue life among the tested configurations. The form factor exerted a decisive influence on the magnitude of the bending stress compared to the stress correction factor. For the considered loading conditions, deflection-induced load sharing occurred in the 20°/20° and 20°/34° configurations but was absent in the 34°/20° configuration. Failure analysis indicated that a high stress concentration caused multiple cracks in the fillets of asymmetric gears.
Antioxidant Activity of New Carvone Derivatives
Authors: Pombal Sofia , M. Roncero Alejandro , E. Tobal Ignacio , García Nieves , Silva Lúcia , Diez David , Mondolis Eily , Mero Aldahir , Morán-Pinzón Juan , Guerrero Estela I. , Rodilla Jesús M.
Published: February 2020

Carvone is one of the most versatile synthons in organic synthesis. It has been used as starting material for a huge number of organic syntheses of natural products with interesting biological activities. This manuscript communicates the antioxidant activity against superoxide of carvone and several derivatives.
Assessing a Student With a Rare Disease
Authors: Roesler Megan A. , Obst Barbara
Published: February 2020

An assessment tool, “Assessing a Student with a Rare Disease,” was developed by the Specialized Health Needs Interagency Collaboration program and introduced at NASN’s 51st annual conference in Denver, Colorado. The goal of the tool is to support the school nurse as the medical expert in the educational setting by using a comprehensive prompt to gather information about the student’s health condition and the possible impact on student’s medical, cognitive, and behavioral needs at school.