bluuebunny/crossref_metadata_2025 huggingface dataset:
IDENTIFIKASI DAERAH RAWAN LONGSOR DENGAN MENGGUNAKAN SISTEM INFORMASI GEOGRAFIS DI KECAMATAN ANGKONA KABUPATEN LUWU TIMUR
Authors: Nursia Nursia , Boceng Annas , Ibrahim Bakhtiar
Published: June 2024

This study aims to determine areas prone to landslides using a geographic information system in Angkona District, East Luwu Regency. Starting from April to May 2021, this study uses a scoring and weighting method for the parameters causing landslides and overlays maps using GIS. The parameters used are rainfall, slope, soil type, geology and land use. The results showed that the landslide-prone area in Angkona District consisted of five levels of vulnerability, namely the level of safe vulnerability with an area of 15,679.02 ha or 53.55%, the level of vulnerability to Slightly Vulnerable with an area of 8,923.50 ha or 30.48%, the level of vulnerability Sufficiently Vulnerable with an area of 3,089.61 ha or 10.55%, the level of Vulnerability with an area of 455.14 ha or 1.55% and the level of vulnerability in Very Vulnerable with an area of 1,132.03 ha or 3.87%.
EVALUASI KESESUAIAN LAHAN TANAMAN JAGUNG (Zea mays L.) DI KECAMATAN BANGKALA KABUPATEN JENEPONTO
Authors: Pertiwi Winda , Tjoneng Amir , Ibrahim Bakhtiar
Published: June 2024

Land is the physical environment which includes soil, climate, relief, hydrology and vegetation, where these factors influence potential use both in the past and in the future. The aim of the research is to determine the actual land suitability, potential and limiting factors for corn (Zea mays L.) in Bangkala District, Jeneponto Regency. The method used in this research is a survey method and determining land suitability classes based on the FAO method with limiting factors and land characteristics including. The research results show that the actual land suitability for cultivating corn is sufficient (S2) for endoaquepts and haplusults soil types with the limiting factors c-organic, P2O5 and K2O, salinity and slope. Efforts to improve the application of organic materials, SP-36 fertilization, KCl for making terrace mounds. Marginal suitability (S3) on eutrudepts and kandiudults soil types with the danger of erosion and slopes. Improvement efforts in making terraces are intended to slow down the rate of ground surface flow and accommodate more air to seep into the soil.
PENGARUH BERBAGAI KONSENTRASI PUPUK DAUN GROWMORE TERHADAP PERTUMBUHAN TANAMAN HIAS MONSTERA (Monstera adansonii)
Authors: Gani Iin Syarifratiwi , Subaedah St. , Ralle Andi
Published: June 2024

This study aims to determine the effect of various concentrations of Grow More fertilizer on the growth of Monstera ( Monstera adansonii ) ornamental plants. This research was carried out in Minasa Upa Village, Bontoa District, Maros Regency, Sulawesi Province. South, from October 2021 to January 20 2 2. This study was arranged based on a randomized block design consisting of 5 treatments, namely without Growmore fertilizer (control), giving Growmore fertilizer with a concentration of 0.5 g/l water, a concentration of 1 g/l of water, a concentration of 1.5 g/l of water and a concentration of 2 g/l of water. Data were analyzed by analysis of variance. If there is a significant effect, then further test with the BNT test. Parameters observed in this study were an increase in plant height, an increase in the number of leaves, leaf length, and leaf width. The results showed that the application of Growmore with a concentration of 2 g/l water had a good effect on the increase in plant height, namely 22.99 cm, the number of leaves increased by 5.44, leaf length was 17.13 cm, leaf width was 9.80 cm.
EVALUASI KESESUAIAN LAHAN TANAMAN RAMBUTAN (Nephelium lappaceum) DI KECAMATAN BUNGAYA KABUPATEN GOWA
Authors: Putra Mahyudin , Boceng Annas , Syarif Muhammad Munawir
Published: June 2024

This research is motivated by the function of land as a resource that can be utilised optimally for human life. The purpose of the research was to determine the actual and potential land suitability and limiting factors of rambutan plants in Bongaya District, Gowa Regency. The method used in this research is the survey method and the determination of land suitability class based on FAO with the approach of limiting factors/land characteristics. The results of the analysis of the land suitability of rambutan plants in Bungaya District, Gowa Regency that the actual land suitability of land units 9, 11, 13, 15 and 16 with the suitability class is marginally suitable (S3), while land units 12 and 14 are moderately suitable (S2), while the potential land suitability of all land units is marginally suitable (S3). Limiting factors of actual land suitability are soil depth, total N, K2O, slope and surface rock. While the limiting factors of potential land suitability are solum depth and surface rock
PENGARUH KOMPOSISI DAN TAKARAN KOMPOS ECENG GONDOK TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN TIMUN JEPANG (Cucumis sativus var japonese L.)
Authors: Nur Muhamman Andika , Sabahannur St. , Gani Mahir S.
Published: June 2024

This study aims to determine the effect of the composition, dosage and interaction of water hyacinth compost on the growth and production of Japanese cucumber (Cucumis sativus var japonese L.). The method used was a factorial randomized block design (RBD) with 2 treatment factors. The first factor is the composition which consists of 3 levels (Water hyacinth, WaterHyacinth + Chicken, Water hyacinth+goat manure) and the second factor is the dosage of water hyacinth compost which consists of 3 levels (40g, 80g, 120g). The results showed that the composition of water hyacinth + chicken manure had the best effect on the growth and production of zucchini on the productivity parameter of 12.87 tons/ha. The dose of water hyacinth compost 120g/polybag is better for the growth and production of Japanese cucumber plants on the parameters of plant height of 152.78 cm, number of leaves of 14.22 strands, fruit length of 27.16 cm, fruit diameter of 5.85 cm and productivity of 13.04 tonnes/ha. The interaction between water hyacinth + chicken manure at a rate of 120g/polybag gave the best effect on growth and production in the fruit weight parameter of 835g/plant.
PENGARUH PUPUK ORGANIK CAIR DAN KOMPOSISI JENIS MEDIA TANAM TERHADAP PERTUMBUHAN TANAMAN AGLAONEMA LIPSTIK (Aglaonema crispum)
Authors: Hidayat Nur Khotimah Giska Ariwani , Alimuddin Suraedah , Ralle Andi
Published: June 2024

This study aims to determine the effect of aminosong liquid organic fertilizer and the influence of the composition of the type of planting media on the growth of aglaonema lipstick plants. This research was conducted in Sudiang Village, Biringkanaya District, Makassar. This study was conducted in the form of a 2 factor factorial pattern Group Randomized Design (RAK). The first factor is the application of liquid organic fertilizer with 4 levels of treatment, namely: without fertilizer, 1 ml/L water, 2 ml/L water and 3 ml/L water. The second factor is the composition of the type of planting media with 4 levels of treatment, namely: (soil: compost: burnt husks), (soil: compost: cocopeat), (soil: burnt husks: cocopeat) and (soil: compost: burnt husks: cocopeat). The results showed that the treatment of POC Aminosong and the treatment of the composition of the type of growing media had a real effect on all parameters.
Antioxidant Activity of Musa Paradisiaca (Banana) Soft Pith and Its Cytotoxicity Against Oral Squamous Carcinoma Cell Lines
Authors: Abd Ghafar Siti Aisyah , Hasan Fikri Ira Hazwani , Eshak Zolkapli
Published: June 2024

Musa paradisiaca also known as banana possess great medicinal value such as haematopoietic, immunomodulatory, antifungal, anti-diabetic and antioxidant effects. Antioxidant and antiproliferative activities between two different species, banana soft pith (BSP) Awak and Abu were conducted in this study. Briefly, BSP were collected (Baling, Kedah) and extracted by 70% ethanol forming crude extract. The crude extracts were then fractionated by n-hexane, ethyl acetate, butanol and water. All BSP extracts and fractions were subjected to total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazil (DPPH) free radical scavenging assay, ferric reducing antioxidant potential (FRAP) assay and cytotoxic assay screening (MTT). Fraction ethyl acetate from BSP Abu showed the highest cytotoxic activity towards HSC-4 cell lines (26.95 ± 1.80 µg/mL) and the highest TPC (12.25 ±0.39 mg GAE/g) and FRAP assay (191.03 ± 0.83 mg FeSO4/g) values as compared to other fractions among BSP Abu. However, TPC (13.93 ± 0.28 mg GAE/g) and TFC (441.59 ± 19.31 mg QE/g) values of BSP Awak were found to be higher as compared to BSP Abu.
Nicholaus de Heybech of Erfurt, Table Maker and Copyist
Authors: Chabás José , Goldstein Bernard R.
Published: June 2024

Nicholaus de Heybech (fl. 1384–1394) is the author of a clever and compact solution to a major challenge for medieval astronomers: finding the time from mean to true syzygy. His table and associated canon for that purpose are now found in 30 manuscript copies, which means that this table was one of the most widely diffused single tables in Alfonsine astronomy. In this article, we present two different and hitherto unnoticed tables by Nicholaus de Heybech for determining mean syzygy, which nicely complement the table that is already known, and we gather the information available on another aspect of his activity beyond table making, as a copyist of texts and tables mainly in mathematical astronomy.
How to cite: Chabás, J., Goldstein, B.R. Nicholaus de Heybech of Erfurt, Table Maker and Copyist. Aestimatio: Sources and Studies in the History of Science (2023) 4: 1-21. https://doi.org/10.33137/aestimatio.v4.42935
Epigenetic regulation of megakaryopoiesis and platelet formation
Authors: Xu Baichuan , Ye Xianpeng , Wen Zhaoyang , Chen Shilei , Wang Junping
Published: June 2024

Platelets, produced by megakaryocytes, play unique roles in physiological processes, such as hemostasis, coagulation, and immune regulation, while also contributing to various clinical diseases. During megakaryocyte differentiation, the morphology and function of cells undergo significant changes due to the programmed expression of a series of genes. Epigenetic changes modify gene expression without altering the DNA base sequence, effectively affecting the inner workings of the cell at different stages of growth, proliferation, differentiation, and apoptosis. These modifications also play important roles in megakaryocyte development and platelet biogenesis. However, the specific mechanisms underlying epigenetic processes and the vast epigenetic regulatory network formed by their interactions remain unclear. In this review, we systematically summarize the key roles played by epigenetics in megakaryocyte development and platelet formation, including DNA methylation, histone modification, and non-coding RNA regulation. We expect our review to provide a deeper understanding of the biological processes underlying megakaryocyte development and platelet formation and to inform the development of new clinical interventions aimed at addressing platelet-related diseases and improving patients’ prognoses.
Clinicobiochemical Parameters of Cytomegalovirus IgM and IgG positive Biliary Atresia and their Relation with Serological Titer in Infants.
Authors: Akter Sharmin , Halim Kazi Shafiqul , Mazumder Wahiduzzaman , Alam Rubayat , Nahid Khan Lamia , Rukunuzzaman Md
Published: June 2024

Cytomegalovirus (CMV) associated Biliary atresia (BA) is one of the clinical classification of Biliary atresia (BA). There is a hypothesis that CMV IgM positive BA is a clinically different entity and prognosis is poor. The aim of this study was to evaluate the clinical and biochemical parameters of CMV IgM and CMV IgG positive BA in one to six month old infants and their relation with serological titer. This cross-sectional study was carried out from January 2019 to June 2022 in the department of Pediatric Gastroenterology and Nutrition, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. A total of 48 infants were included in this study as study subject who were diagnosed as biliary atresia with positive CMV IgM & CMV IgG. After taking written informed consents data were taken from parents or legal guardians by using a structured questionnaire. Data were analyzed by statistical package for social sciences (SPSS), version- 23.  Majority of the cases (58.3%) were in 2-4 month of age group, 70.8% were male and male-female ratio was almost 2.5:1. Regarding birth history most of the infants (95.8%) were term baby and  two-third (66.7%) of them was appropriate for gestational age (AGA). This study observed the onset of jaundice among the infants, here 60.4% of them detected jaundice jaundice within 7 days, 22.9% within 7-14 days and 16.7% after 14 days. About three fourth (73%) of infants presented with intermittent pale stool and more than one-fourth (27%) had persistent pales tool. One fourth 12(25%) patient had features of coagulopathy. The mean of total bilirubin, direct bilirubin, alanine transaminase (ALT) and gamma-glutamyl transpeptidase (GGT ) were 11.89±4.0, 8.27±3.42, 162.67±103.09 and 669.46±543.57 respectively; The mean of the titers of  CMV IgM and CMV IgG were 50.84±33.09 and  82.40±53.79  respectively. The prolong international normalised ratio (INR ) was in 30.8% of infants and mean INR was 2.44±2.54. Study finds that CMV IgM titer level was correlated with total bilirubin (r=-0.256; p<.05) and direct bilirubin (r=-0.365; p<.05); where CMV IgG titer level was correlated with age (r=-0.362; p<.05) and INR (r=0.271; p<.05). It may be concluded as increase in age would increase titer of IgG and increase in titer of IgG is associated with increase coagulopathy. Elevated levels of CMV IgM titer correlated with bilirubin level or cholestasis.
Bangladesh Med J. 2023 Jan; 52(1): 12-17
Pengaruh PembeIajaran STEAM Terhadap Kemampuan Berpikir Kritis dan Kreativitas Anak Usia 5-6 Tahun di RA Fathimaturridha Medan
Authors: Permata Risky Ayu , Rafida Tien , Sitorus Ahmad Syukri
Published: June 2024

PeneIitian ini bertujuan untuk mengetahui : (1) Mengetahui pengaruh pembeIajaran STEAM terhadap kemampuan berpikir kritis anak usia dini, (2) Mengetahui pengaruh pembeIajaran STEAM terhadap kemampuan kreativitas anak usia dini. PeneIitian ini diIaksanakan pada tanggaI 17 Januari hingga 17 Februari 2023, PeneIitian ini menggunakan jenis peneIitian kuantitatif deskriptif.PeneIitian ini meIibatkan 2 orang guru dan 41 anak di keIas Semangka dan keIas Rambutan. Instrumen dan teknik pengumpuIan data yang digunakan adaIah instrumen peneIitian, dan angket pengamatan. HasiI peneIitian ini menunjukkan bahwa 1) terdapat pengaruh pembeIajaran STEAM terhadap kemampuan berpikir kritis anak usia 5-6 tahun di RA Fathimaturridha Medan. HasiI data kemampuan berpikir kritis anak mempunyai niIai thitung(2.143) > ttabeI(2,021) dan sig.2-taiIed (0,008) < α = 0,05. 2) Terdapat pengaruh pembeIajaran STEAM terhadap kreativitas anak usia 5-6 tahun. Data kreativitas anak mempunyai niIai thitung(2.690) > ttabeI(2,021) dan sig.2-taiIed (0,001) < α = 0,05.
Peran Guru Dalam Pendampingan Ekplorasi Pembelajaran Sains di TK Tunas Mekar Sari Denpasar
Authors: Adnyani Dewi I Gusti Ayu Cintya Widi , Suardika I Komang
Published: June 2024

Peranan guru dalam pendampingan  sangat penting. Berbagai penelitian telah dilakukan tentang peran guru pada pembelajaran sains sederhana pada anak. Tujuan penelitian: Pertama, untuk mengetahui bagaimana peran guru dalam pendampingan proses ekplorasi anak pada pembelajaran sains. Kedua, untuk mengetahui bagaimana implikasinya terhadap anak, guru, dan lingkungan sekolah.Penelitian menggunakan metode kualitatif dengan pendekatan deskriptif. Sumber data adalah kepala sekolah, guru, dan anak-anak di TK Tunas Mekar Sari Denpasar. Teknik pengambilan data dengan wawancara, observasi dan studi kepustaakan. Analisis data dilakukan dengan teori humanisme Ki Hajar Dewantara. Hasil penelitian menunjukkan : 1. peran guru sebagai pendamping, fasislitator, dan tutor (pengajar)  2. Implikasinya bagi anak-anak; anak memperoleh penglaman langsung dengan tahu, nama-nama tanaman dan lingkungan, mengerti proses sains sederhana dengan bahan alam. Bagi guru; guru dapat secara kreatif dan mudah mengenalkan dan memanfaatkan media alam sebagai bahan sains sederhana. Bagi lingkungan; keberlangsungan hidup lingkungan akan terjaga. Kesimpulan penelitian ini adalah pada setiap perannya guru dapat selalu mendampingi anak usia dini dalam memaksimalkan proses ekplorasi termasuk bekerjasama dengan orang tua guna keberhasilan pembelajaran.
Implementasi Model ATIK Dalam Pembelajaran Aquascape Pada Anak Usia Dini
Authors: Ningsih Nikem Kurnia , Watini Sri
Published: June 2024

Penelitian ini dilatar belakangi dengan melemahnya kemampuan kreativitas anak disebabkan oleh kurangnya dukungan dan motivasi dari lingkungan sekitar seperti orangtua, guru dan teman sebaya yang menyebabkan motivasi mereka kurang dihargai dan mudah terganggu akibat pemberian atau pemakaian gadget yang kurang terkontrol oleh orang tua serta penggunaan model pembelajaran yang kurang tepat dilakukan guru pada anak saat melakukan kegiatan pembelajaran sehingga melemahnya minat anak untuk berkreativitas. Maka peneliti mengedepankan tentang Implementasi Model ATIK dalam pembelajaran aquascape yang bertujuan untuk meningkatkan kemampuan kreativitas pada anak usia dini Penelitian dilakukan dengan menggunakan metode pendekatan kualitatif melalui kegiatan praktek secara langsung. Pengembangan media aquascape telah diuji tingkat variable kesediaan bahan, keamanan dan ketahanan bahan media. Selanjutnya pengujian ukuran, dan proporsi detail serta tingkat praktis sesuai kebutuhan siswa. Penelitian dilakukan di Sekolah Alternatif Anak Jalanan (SAAJA) Jakarta Selatan dan PAUD KB Mutiara Ceria Kabupaten Tangerang dengan mengimplementasikan Model Amati Tirukan dan Kerjakan (ATIK) yang sesuai dengan gaya belajar dan karakteristik siswa, dilakukan menggunakan media pembelajaran inovasi baru yaitu aquascape yang telah dirancang dan disesuaikan dengan pendidikan anak usia dini sehingga terbukti penelitian ini dapat meningkatkan kemampuan kreativitas anak usia dini. Hasil dari penelitian Implementasi Model ATIK dalam pembelajaran aquascape dapat menumbuhkan minat dan kreativitas serta keingintahuan anak dalam belajar di PAUD.
Kata Kunci: Model ATIK, Pembelajaran Aquascape, Anak Usia Dini.
ANALISIS PERKEMBANGAN SOSIAL EMOSIONAL ANAK USIA 4-5 TAHUN DITINJAU DARI PENERAPAN APE BUSY BOOK DI TK TA PENDEM 01
Authors: Ayatina Nurul , Zulfahmi Muhammad Nofan
Published: June 2024

Perkembangan sosial emosional merupakan proses dimana anak belajar untuk berperilaku yang berhubungan dengan individu untuk hidup dan berinteraksi atau melakukan kegiatan sosial dengan individu lain dalam kehidupan sehari hari. Perkembangan sosial emosional dapat dikembangkan dengan melalui proses pembelajaran. penelitian ini memiliki tujuan untuk mendeskripsikan dan mengetahui perkembangan sosial emosional yang terjadi pada anak usia 4-5 tahun melalui permainan busy book.  Pendekeatan penelitian yang digunakan dalam penelitian ini dengan menggunakan pendekatan penelitian kualitatif dengan jenis deskriptif kualitatif untuk mendeskripsikan terkait implementasi APE busy book sebagai peninjau dari capaian perkembangan anak usia 4–5 tahun di lembaga TK TA Pendem 01. Penelitian ini menggunakan teknik pengumpulan data observasi, wawancara dan dokumentasi. Penelitian yang dilakukan menjelaskan bahwa dengan menggunakan media busy book anak sudah mencapai indikator yang diteliti oleh peneliti yaitu anak mampu berantusias dalam mengikuti rangkaian permainan yang ada di busy book, menaati peraturan yang berlaku dalam permainan, percaya diri untuk menjawab pertanyaan yang dikasih pendidik dan mampu berinteraksi dengan sesama teman.
Implementasi Mendongeng dalam Meningkatkan Kemampuan Bahasa Anak Usia Dini
Authors: Pradana Pascalian Hadi , Djamali Fadil , Khoiriyah Ainun Nasyiyatul
Published: June 2024

Abstrak: Tujuan penelitian ini bagaimana impelementasi mendongeng dalam meningkatkan kemampuan Bahasa anak usia dini di SPS Flamboyan 54. Mendongeng merupakan sebuah seni tentang cerita dari suatu peristiwa dan disampaikan secara lisan. Kegiatan mendongeng yang melibatkan pendengaran dan pengamatan oleh anak-anak akan menumbuhkan dari segi Bahasa anak itu sendiri. Penelitian ini menggunakan penelitian tindakan kelas. Pengumpulan data yang diperlukan dalam penelitian ini diperoleh melalui kegiatan observasi dari pelaksanaan kegiatan mendongeng. Mendongeng dapat meningkatkan kemampuan Bahasa anak yakni pada aspek menceritakan kembali isi cerita secara sederhana, menjawab pertanyaan tentang dongeng dengan baik, dan melanjutkan isi cerita dongeng. Peningkatan terjadi pada siklus I ke siklus I pada masing-masing aspek penilaian. Aspek menceritakan kembali isi cerita secara sederhana mengalami peningkatan yakni pada siklus I sebesar 50% atau 7 anak menjadi 85,8% atau 12 anak yang memenuhi indicator keberhasilan. Pada aspek menjawab pertanyaan tentang dongeng dengan baik juga mengalami peningkatan, yakni pada siklus I sebesar 50% atau 7 anak menjadi 85,8% atau 12 anak yang memenuhi indicator keberhasilan. Pada aspek melanjutkan isi cerita dongeng juga mengalami peningkatan yakni pada siklus I sebesar 71,4% atau 10 anak menjadi 92,9% atau 13 anak yang memenuhi indicator keberhasilan. Dengan hasil ini karena pada siklus II telah memenuhi indicator keberhasilan, maka penelitian telah selesai.
Austenitizing Temperature and Quenching Media Effects on Hardness and Microstructure in Hardening of AISI 1040 Steel
Authors: Pangestu Mulyo Aji , Rosidah Afira Ainur
Published: June 2024

Hardening process is an important to make materials have harder properties related to wear resistance. This research determined the effects of austenitizing temperature and quenching media on the hardness and microstructure of AISI 1040. The austenitizing temperatures varies at 850°C, 900°C, and 950°C with PVA 10%, SAE 20W-50 oil, and salt water as quenching media. The method to measure hardness was the Brinell hardness test. The results showed changes in the microstructure from untreated steel with the structures of ferrite and pearlite to bainite and martensite. The highest hardness value of 416.22 kgf/mm2 was obtained in specimens with salt water media at an austenitizing temperature of 850°C.
The Effects of Ethnoscience Integrated Problem-Based Learning Models on Students' Critical Thinking Skills
Authors: Gummah Syifaul , Fitri Muliana , Prayogi Saiful , Asy'ari Muhammad
Published: June 2024

In the contemporary educational landscape, cultivating critical thinking skills is imperative for students to thrive in the 21st century. Recognizing that critical thinking is not an instantaneous process, it is essential to employ didactic mechanisms specifically designed to hone this skill. Traditional expository teaching methods have been deemed insufficient in fostering critical thinking among students. Therefore, effective pedagogical intervention models are warranted, allowing students to engage authentically in everyday contexts. This study assesses the impact of an ethnoscience-integrated problem-based learning model on students' critical thinking skills. Employing a quasi-experimental design with a non-equivalent control group, the research unfolded in a secondary school in Mataram City, with a sample of 66 students divided into experimental and control classes. The experimental class experienced instruction through an ethnoscience-integrated problem-based learning model, while the control class adhered to traditional (expository) teaching methods. Critical thinking skills were assessed using a validated test instrument encompassing analysis, inference, evaluation, and decision-making indicators. Descriptive and statistical analyses were applied to scrutinize the data. The results revealed that students in the experimental class exhibited higher levels of critical thinking skills than their counterparts in the control class, which was statistically significant. In conclusion, this research establishes a significant positive influence of the ethnoscience-integrated problem-based learning model on students' critical thinking skills. Furthermore, it reaffirms the inadequacy of traditional (expository) teaching in enhancing students' critical thinking abilities.
MİLLÎ MÜCADELE DÖNEMİNDE MUĞLA VE ÇEVRESİNDEKİ GELİŞMELERİN MENTEŞE GAZETESİ ÜZERİNDEN DEĞERLENDİRİLMESİ
Authors: Kıyanç Sinan , Korkmaz Erdal
Published: June 2024

Bu çalışmada Millî Mücadele’nin hemen başında Muğla’da çıkarılan Menteşe Gazetesi ele alınmaktadır. İzmir’in Yunanlılar tarafından işgal edilmesi Anadolu’nun birçok yerinde olduğu gibi Muğla’da da tepkilere neden olmuş, bu tepkilerin bir göstergesi olarak Menteşe Gazetesi yayınlanmaya başlamıştır. Hafız Sabri Aksoy’un imtiyaz sahibi olduğu gazetenin sorumlu müdürlüğünü Şevket Emin Gölcüklü, yazı işleri müdürlüğünü ise Mehmet Emin Kâmili Bey yürütmüştür. Gazete, İtalyanlar tarafından getirilen matbaa ile günümüzde İskender Alper Kültür Merkezi olarak adlandırılan o zamanki adıyla İstanbul Oteli’ndeki Hayat Kulübü’nde yayınlanmıştır. Kısa yayın hayatında yedi sayı yayınlanabilen, sekizinci sayısı kentin İtalyan işgaline karşı Mutasarrıf Hilmi Bey tarafından kaleme alınan makale nedeniyle basılamamıştır.
Kentin İtalyanlar tarafından işgal edilmesi üzerine yayın hayatına son veren gazete, özellikle İzmir ile başlayan Yunan işgaline karşı tepkileri içermiştir. İşgal edilen topraklarda Türk nüfusunun yoğun olduğunu, bu toprakların Türk toprakları olduğunu vurgulayan gazetenin yayınlanmasında, Millî Mücadele yıllarında kentin önde gelen isimlerinin emeği bulunmaktadır. Kısa yayın ömrüne karşın gazete, kentin Millî Mücadele yıllarındaki tepkisini göstermesi açısından birinci el kaynak teşkil niteliği taşımaktadır. Gazete Kuvayı Millîye birlikleri ile 57. Alay’ın hareketleri hakkında, Denizli, Burdur, Isparta, İzmir ve Aydın’daki ilerlemelerini ortaya koymuştur. Ağırlıklı olarak Yunanlıların İzmir ve Aydın işgaline yer verilmiş, işgal nedeniyle bu topraklarda yaşananları ele almıştır. Harici haberler ile uluslararası gelişmelere sınırlı da olsa yer verilmiştir. Bunun yanı sıra yerel haberlere de yer veren gazete o günkü Muğla’nın sosyoekonomik hayatı hakkında bilgiler de barındırmıştır. Gazetenin suretlerinin bulunamaması nedeniyle hakkında çok az bilgiye sahip olduğumuz Menteşe Gazetesi’nin suretleri üzerinden ele alınması bakımından bu araştırma ilk olma özelliği taşımaktadır. Araştırmada belge tarama yöntemi ile gazete suretleri başta olmak üzere birinci el kaynaklar ve araştırma eserlerinden elde edilen bilgi ve bulgularla, Muğla’nın işgaller karşısında güçlü bir tepki gösterdiği savunulmaktadır.
PENINGKATAN KUALITAS PELAYANAN PADA KANTOR KELURAHAN MANGGALA MELALUI PENYUSUNAN STANDAR OPERASIONAL PROSEDUR
Authors: Dalaiya Andi , Musdalifah Musdalifah
Published: June 2024

Pelayanan publik sebagai layanan yang berbentuk jasa maupun barang yang menjadi tanggung jawab dan dilaksanakan oleh pemerintah guna memenuhi kebutuhan masyarakat kebutuhan masyarakat maupun dalam rangka melaksanakan ketentuan peraturan perundang-undangan. Apabila pelayanan publik yang diberikan kepada masyarakat efektif dan efisien maka masyarakat merasakan kualitas pelayanan yang baik dari penyelenggara pelayan publik sehingga, untuk dibutuhkannya Standar Operasional Prosedur (SOP) sebagai pedoman yang dapat mempermudah penyelenggara pelayanan dalam memberikan pelayan terkhususnya organisasi pemerintahan. Adanya Standar Operasional Prosedur, penyelenggaraan administrasi pemerintahan dapat berjalan dengan pasti. Pada penelitian bertujuan penyusunan Standar Operasional Prosedur pelayanan pada Kantor Kelurahan Manggala dalam meningkatkan kualitas layanan. Metode yang digunakan dalam penyusunan Standar Operasional Prosedur yaitu pendekatan yang digunakan adalah pendekatan kualitatif dan metode pengumpulan data berupa observasi, wawancara dan telaah dokumen. Penelitian ini menghasilkan karya yaitu Standar Operasional Prosedur, terdapat lima prosedur yang disusunkan SOP diantaranya, keterangan kematian, keterangan domisili sementara, keterangan tidak mampu, pengantar nikah dan keterangan usaha. Ada beberapa tahapan yang dilakukan dalam penyusunan SOP yaitu melakukan penilaian kebutuhan dengan menentukan prosedur pelayanan yang akan dibuatkan, kemudian tahapan pembuatan SOP dengan mengumpulkan informasi yang terkait lalu dibuat sesuai dengan pedoman, terakhir review dan sosialisasi dengan pelaksana pemberi pelayan terkait dengan SOP yang telah dibuat.
Endovascular Stenting for Superior Vena Cava Syndrome – A Systematic Review
Authors: Anyagwa Onyekachi Emmanuel , Dairo Oluwatoyin Adalia , Tak Rajeeka Singh , Alkodami Lamia A. , Azim Mohammad , Ahuja Swapnil , Oommen Kenas Shaji , Shakeel Maryam , Ajah Divine-Blessing Chinwendu , Alkodami Shaima , Kervalidze Lika , Kassem Maha
Published: June 2024

Superior vena cava syndrome (SVCS) results from the obstruction or narrowing of the superior vena cava, causing venous congestion and various symptoms such as facial and upper limb swelling, shortness of breath, chest pain, coughing, and, in severe cases, dizziness and headache. The primary treatment for SVCS is balloon angioplasty with endovascular stenting. Post-procedural complications are influenced by factors such as SVCS aetiology, comorbidities, and the presence of arteriovenous fistulas. This review examined eight clinical studies to assess the effectiveness of percutaneous endovascular stenting and associated complications, focusing on improving patient prognosis. The research, conducted through internet search engines and reputable databases, revealed that percutaneous endovascular stenting demonstrated efficacy ranging from 95–100% in addressing SVCS. Common complications post-procedure included SVC narrowing recurrence, airway constriction, and mortality, often linked to malignancy. The findings emphasise the need to refine therapeutic approaches, especially in addressing the root cause of SVCS, which is frequently malignancy. Consequently, implementing additional protocols to reduce the risk of SVCS development is crucial. This comprehensive review provides insights into the effectiveness of endovascular stenting in treating SVCS, highlighting the importance of tailored approaches and ongoing efforts to enhance patient outcomes.
Frequency Determination of Central Line Associated Bloodstream Infection at a Renal Care Centre
Authors: Moin Safia , Salman Bina , Ahmad Aasim
Published: June 2024

Background: Central line-associated bloodstream infection (CLABSI) is a serious infection typically increasing morbidity and mortality in patients with chronic kidney disease (CKD). It can be prevented through proper insertion techniques and management of the central line (CL). However, the first step in reducing the CLABSI rate is to define the extent of the problem through proper surveillance. This study aimed to determine the frequency of CLABSI in patients with CKD at a specialised renal care centre.

Methods: The authors conducted a retrospective observational study to determine the frequency of CLABSI in patients with CKD between November 2021–September 2022 at their institute. They included all patients with CLs registered at their institute. Primary CLABSI was defined as CLABSI attributable to their hospital, while secondary CLABSI was defined as those not attributed to their hospital.

Results: Fifty-nine incidences of CLABSI were identified in a total of 310 patients with CL and 1,413 CL days, giving a total of 42 CLABSI incidences per 1,000 CL days. Primary CLABSI was more common (n=36 [61%]) than secondary CLABSI (n=23 [39%]). Most of the patients recovered (53 [89.8%]); however, four (6.9%) patients expired. Most of the patients who recovered had permanent vascular access (n=32 [60.4%]), internal jugular placement (n=44 [83%]), and primary CLABSI (n=33 [62.3%]), although the p-values were non-significant.

Conclusion: Strict implementation of CLABSI prevention bundles for line insertion and its maintenance and regular surveillance using laboratory confirmed cases is needed to reduce the rates of CLABSI.
Caregiver Burden, Resilience, and Wellbeing in Cases of Severe Cutaneous Adverse Drug Reactions
Authors: Mukherjee Shatavisa , Tripathi Santanu Kumar , Saha Bibhuti
Published: June 2024

Background: Severe cutaneous adverse reactions (SCAR) can be traumatic and emotionally distressing for both the patients and their families. However, caregivers must also take care of themselves to prevent burnout. They should seek respite when needed, and prioritise self-care activities that maintain their own wellbeing.

Aim: This study aimed to explore the caregiver’s burden and resilience in patients experiencing SCARs.

Methods: A cross-sectional observational study included patients experiencing SCARs who presented with their caregivers. Patients and their caregivers were enquired about their sociodemographic variables, and were administered the Brief Resilience Scale (BRS). Caregivers were further given the Burden Scale for Family Caregivers (BSFC) and the World Health Organization Quality of Life Brief (WHOQOL-BREF).

Results: Quality of life assessment suggested diminished physical and psychological health among the caregivers. Burden grade conferred 27.1% of caregivers experiencing severe burden, while 56.5% and 16.5% of caregivers experienced mild and moderate burden, respectively. Furthermore, 85.9% of caregivers showed low resilience. Increase in reaction severity was associated with greater caregiver burden and low resilience (p=0.001). Higher age and lower socioeconomic strata were also associated with increased burden and lesser caregiver resilience (p<0.001).

Conclusion: Providing care for individuals with SCARs can be physically and emotionally demanding, requiring assistance with daily activities, wound care, and medication management. Caregivers may face challenges as they navigate the complexities of the condition; hence, understanding and addressing the challenges faced by caregivers is of utmost importance.
UJI AKTIVITAS ANTIBAKTERI SEDUHAN KOMBINASI JAHE (Zingiber officinale), SEREH (Cimbopogon citratus) DAN KAYU MANIS (Cinnamomi burmanii) TERHADAP BAKTERI Eschericia colli
Authors: Khairunnisa  , Sri Idawati  , Ajeng Dian Pertiwi  , Sri Rahmawati
Published: June 2024

Kontaminasi mikroba pada saat ini adalah salah satu masalah yang dihadapi dalam kehidupan manusia yang berkaitan dengan penyebab penyakit infeksi. Pengobatan penyakit infeksi pada  umumnya menggunakan obat antibiotik. Namun,  penggunaan antibiotik secara berlebihan dapat menimbulkan resiko seperti resistensi bakteri. Salah satu pilihan alternatif pengganti antibiotika dengan menggunakan obat tradisional yang berasal dari tanaman seperti Rimpang Jahe (Zingiber officinale), Batang Sereh (Cimbopogon citratus), Dan Kulit Batang Kayu Manis (Cinnamomi burmanii). Tujuan dari penelitian ini yaitu untuk mengetahui aktivitas antibakteri seduhan kombinasi jahe, sereh, dan kayu manis terhadap bakteri Eschericia colli serta untuk mengetahui berapa konsentrasi yang paling efektif sebagai antibakteri dari seduhan kombinasi jahe, sereh, dan kayu manis terhadap bakteri Eschericia colli. Metode dalam penelitian ini menggunakan metode true eksperimental dimana seduhan kombinasi jahe,sereh,dan kayu manis dibuat sebanyak empat konsentrasi yaitu 60%, 45%, 30%, 15% , dengan kontrol positif (+) antibiotik chloramphenicol 250 mg dan kontrol negatif (-) menggunakan aquades. Hasil penelitian menunjukkan bahwa tidak adanya zona hambat yang terbentuk  pada masing-masing konsentrasi dan kontrol negatif (-), zona hambat yang terbentuk hanya pada kontrol positif (+) dengan diameter rata-rata 24,25 dengan kategori sangat kuat.
Evaluasi Drug Related Problems (DRPs) Pada Pasien Hipertensi di Instalasi Rawat Inap Rumah Sakit Umum Daerah Provinsi NTB
Authors: Baiq Kamilia Apriliani  , Ajeng Dian Pertiwi  , Evi Fatmi Utami  , En Purmafitriah
Published: June 2024

Hipertensi atau yang biasa disebut tekanan darah tinggi merupakan peningkatan tekanan darah sistolik di atas batas normal yaitu lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg. Hipertensi disebut sebagai the silent killer karena penyakit mematikan ini sering sekali tidak menunjukkan gejala atau tersembunyi. Terdapat berbagai kelas antihipertensi yang digunakan dalam terapi hipertensi. Sebagian besar pasien memerlukan antihipertensi seumur hidup dengan kombinasi lebih dari satu obat. Evaluasi Drug Related Problems diperlukan untuk meningkatan efektivitas terapi terutama pada penyakit degeneratif seperti hipertensi. Drug Related Problems (DRPs) merupakan kejadian yang melibatkan terapi obat yang dapat mempengaruhi outcome terapi. Tujuan penelitian ini adalah untuk mengetahui profil pengobatan, kategori Drug Related Problems (DRPs) dan persentase kejadian Drug Related Problems (DRPs) pasien hipertensi di instalasi rawat inap Rumah Sakit Umum Daerah Provinsi NTB. Metode dalam penelitian ini adalah deskriptif kualitatif. Data dalam penelitian ini diambil dari data sekunder (rekam medis) yang ada pada ruang Rekam Medis Rumah Sakit Umum Daerah Provinsi NTB. Hasil penelitian didapatkan 1 pasien berpotensi DRPs, kategori DRPs yang terjadi adalah DRPs kategori kejadian obat yang mungkin terjadi dan kategori kombinasi obat yang tidak tepat atau obat-obatan dan herbal obat-obatan atau obat suplemen makanan. Kejadian DRPs pada penelitian ini sebanyak 5,6%, kejadian non-DRPs sebanyak 94,4% dan persentase tiap kategori DRPs sebanyak 2,12%. Obat yang paling banyak digunakan dalam terapi pasien hipertensi di instalasi rawat Rumah Sakit Umum Daerah Provinsi NTB adalah amlodipin (33,3%).
Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina
Authors: Lu Celine , Hyde David R.
Published: June 2024

Zebrafish possess the ability to regenerate dying neurons in response to retinal injury, with both Müller glia and microglia playing integral roles in this response. Resident Müller glia respond to damage by reprogramming and undergoing an asymmetric cell division to generate a neuronal progenitor cell, which continues to proliferate and differentiate into the lost neurons. In contrast, microglia become reactive, phagocytose dying cells, and release inflammatory signals into the surrounding tissue following damage. In recent years, there has been increased attention on elucidating the role that microglia play in regulating retinal regeneration. Here we demonstrate that inflammatory cytokines are differentially expressed during retinal regeneration, with the expression of a subset of pro-inflammatory cytokine genes upregulated shortly after light damage and the expression of a different subset of cytokine genes subsequently increasing. We demonstrate that both cytokine IL-1β and IL-10 are essential for Müller glia proliferation in the light-damaged retina. While IL-1β is sufficient to induce Müller glia proliferation in an undamaged retina, expression of IL-10 in undamaged retinas only induces Müller glia to express gliotic markers. Together, these findings demonstrate the essential role of inflammatory cytokines IL-1β and IL-10 on Müller glia proliferation following light damage in adult zebrafish.
Ramp-rate control for power quality improvement of renewable grid-integrated microgrid with hybrid energy storage system
Authors: Brahmendra Kumar G. V. , Palanisamy K. , De Tuglie Enrico
Published: June 2024

This paper demonstrates an enhancement of power quality for a photovoltaic (PV) system connected to the grid with a hybrid energy storage system (HESS). The proposed system utilizes a ramp-rate control (RRC) strategy to limit severe fluctuations in the PV power output. Battery storage is integrated to store surplus energy generated by the PV system and is used for continuous power application. A high-power density device, known as a supercapacitor (SC), is employed to mitigate transient fluctuations in the battery. The proposed system facilitates smooth PV power generation, stabilizes the DC bus voltage (VDC), and eliminates source current harmonics induced by non-linear loads. The Shunt Active Power Filter (SAPF) discussed in this paper serves two primary purposes. Firstly, it acts as a reactive power buffer, smoothing out fluctuations and reducing current harmonic distortions. Secondly, it enables active power injection into the grid, utilizing a specific renewable solar PV source. The efficiency of the modeled compensation system is demonstrated by the sinusoidal shape of the current and the compensation of reactive power (RPC). The targeted system showcases the effectiveness of the current setup by exhibiting low total harmonic distortion (THD). The multifunctional features of the proposed system were implemented using the MATLAB/Simulink software, and the results were validated using an OP5700 Hardware-in-the-Loop (HIL) test bench. This integration of distributed power generation capabilities not only enhances the overall power quality but also improves the efficient utilization of renewable energy resources (RESs).
Puberty classifications in beef heifers are moderately to highly heritable and associated with candidate genes related to cyclicity and timing of puberty
Authors: Hess Melanie K. , Mersha Anteneh , Ference Sadie S. , Nafziger Sarah R. , Keane Jessica A. , Fuller Anna M. , Kurz Scott G. , Sutton Courtney M. , Spangler Matthew L. , Petersen Jessica L. , Cupp Andrea S.
Published: June 2024

Introduction: Pubertal attainment is critical to reproductive longevity in heifers. Previously, four heifer pubertal classifications were identified according to attainment of blood plasma progesterone concentrations > 1 ng/ml: 1) Early; 2) Typical; 3) Start-Stop; and 4) Non-Cycling. Early and Typical heifers initiated and maintained cyclicity, Start-Stop started and then stopped cyclicity and Non-Cycling never initiated cyclicity. Start-Stop heifers segregated into Start-Stop-Discontinuous (SSD) or Start-Stop-Start (SSS), with SSD having similar phenotypes to Non-Cycling and SSS to Typical heifers. We hypothesized that these pubertal classifications are heritable, and loci associated with pubertal classifications could be identified by genome wide association studies (GWAS).

Methods: Heifers (n = 532; 2017 – 2022) genotyped on the Illumina Bovine SNP50 v2 or GGP Bovine 100K SNP panels were used for variant component estimation and GWAS. Heritability was estimated using a univariate Bayesian animal model.

Results: When considering pubertal classifications: Early, Typical, SSS, SSD, and Non-Cycling, pubertal class was moderately heritable (0.38 ± 0.08). However, when heifers who initiated and maintained cyclicity were compared to those that did not cycle (Early+Typical vs. SSD+Non-Cycling) heritability was greater (0.59 ± 0.19). A GWAS did not identify single nucleotide polymorphisms (SNPs) significantly associated with pubertal classifications, indicating puberty is a polygenic trait. A candidate gene approach was used, which fitted SNPs within or nearby a set of 71 candidate genes previously associated with puberty, PCOS, cyclicity, regulation of hormone secretion, signal transduction, and methylation. Eight genes/regions were associated with pubertal classifications, and twenty-two genes/regions were associated with whether puberty was attained during the trial. Additionally, whole genome sequencing (WGS) data on 33 heifers were aligned to the reference genome (ARS-UCD1.2) to identify variants in FSHR, a gene critical to pubertal attainment. Fisher’s exact test determined if FSHR SNPs segregated by pubertal classification. Two FSHR SNPs that were not on the bovine SNP panel were selected for additional genotyping and analysis, and one was associated with pubertal classifications and whether they cycled during the trial.

Discussion: In summary, these pubertal classifications are moderately to highly heritable and polygenic. Consequently, genomic tools to inform selection/management of replacement heifers would be useful if informed by SNPs associated with cyclicity and early pubertal attainment.
The effect of smoking in inflammatory bowel disease outcomes
Authors: Alzahrani Basil A. , Aljuhani Jamal A. , Badri Ziyad A. , Alshamrani Rayan M. , Algaows Faisal Suliman , Ahmed Mohamed Eldigire
Published: June 2024

Background

The hallmark of inflammatory bowel disease (IBD) is a persistent inflammation of the digestive system brought on by an imbalance in the gut microbiota. The two IBDs that are most well-known are ulcerative colitis (UC) and Crohn’s disease (CD). The purpose of the current study was to evaluate the Impact of smoking in inflammatory bowel disease.

Methods

Data of 373 patients with IBD divided into 209 Crohn’s disease and 164 with ulcerative colitis disease. cases were collected from king Abdulaziz medical city, Jeddah, Saudi Arabia from 2016-2022. Patients older than 18 years, Patients with a history of cancer other than colon cancer or other GIT disorders were excluded from consideration.

Result

This study involved 373 participants, predominantly with Crohn’s disease 209. The participants exhibited diverse smoking habits, with complications observed in 53.6% of cases. Smoking status and duration showed significant associations with complications, particularly in Crohn’s disease. For ulcerative colitis, smoking correlated with lower complication rates. The analysis of smoking variables and disease remission highlighted nuanced relationships, emphasizing the need for further exploration. Specific associations between smoking and Crohn’s disease site or ulcerative colitis subtypes were observed, suggesting potential influences on disease manifestations.

Conclusion

According to our research, smoking is negatively correlated with experiencing problems from ulcerative colitis (UC), and patients who smoke also appear to have higher rates of remission. Smoking has more issues with Crohn’s disease, though.
Respiratory syncytial virus NS1 inhibits anti-viral Interferon-α-induced JAK/STAT signaling, by limiting the nuclear translocation of STAT1
Authors: Efstathiou Claudia , Zhang Yamei , Kandwal Shubhangi , Fayne Darren , Molloy Eleanor J. , Stevenson Nigel J.
Published: June 2024

Human respiratory viruses are the most prevalent cause of disease in humans, with the highly infectious RSV being the leading cause of infant bronchiolitis and viral pneumonia. Responses to type I IFNs are the primary defense against viral infection. However, RSV proteins have been shown to antagonize type I IFN-mediated antiviral innate immunity, specifically dampening intracellular IFN signaling. Respiratory epithelial cells are the main target for RSV infection. In this study, we found RSV-NS1 interfered with the IFN-α JAK/STAT signaling pathway of epithelial cells. RSV-NS1 expression significantly enhanced IFN-α-mediated phosphorylation of STAT1, but not pSTAT2; and neither STAT1 nor STAT2 total protein levels were affected by RSV-NS1. However, expression of RSV-NS1 significantly reduced ISRE and GAS promoter activity and anti-viral IRG expression. Further mechanistic studies demonstrated RSV-NS1 bound STAT1, with protein modeling indicating a possible interaction site between STAT1 and RSV-NS1. Nuclear translocation of STAT1 was reduced in the presence of RSV-NS1. Additionally, STAT1’s interaction with the nuclear transport adapter protein, KPNA1, was also reduced, suggesting a mechanism by which RSV blocks STAT1 nuclear translocation. Indeed, reducing STAT1’s access to the nucleus may explain RSV’s suppression of IFN JAK/STAT promoter activation and antiviral gene induction. Taken together these results describe a novel mechanism by which RSV controls antiviral IFN-α JAK/STAT responses, which enhances our understanding of RSV’s respiratory disease progression.