bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of COVID-19 pneumonia and acute respiratory distress with ramatroban, a thromboxane A2 and prostaglandin D2 receptor antagonist: A 4-Patient Case Series Report
Authors: Ogletree Martin L. , Chiang Kate Chander , Kulshreshta Rashmi , Agarwal Aditya , Agarwal Ashutosh , Gupta Ajay
Published: January 2022

Importance Hypoxemia in COVID-19 pneumonia is dispositive for hospitalization and mechanical ventilation and contributes to mortality. Other than oxygen supplementation, there is no treatment that resolves hypoxemia in COVID-19 pneumonia. Objective COVID-19 pneumonia sustains a massive increase in lipid mediators, especially thromboxane A2 >> PGE2 > PGD2. Thromboxane A2 induces pulmonary venoconstriction, increases pulmonary capillary pressure and contributes to pulmonary edema. High thromboxane A2 metabolite levels are strongly associated with respiratory failure and mortality in hospitalized COVID-19 patients. Ramatroban (Baynas®, Bayer Yakuhin Ltd., Japan) is an inexpensive, orally bioavailable, thromboxane A2 receptor antagonist. Ramatroban was administered to patients with COVID-19 pneumonia and hypoxemia to explore the effect of thromboxane A2 antagonism on clinical symptoms and outcomes. Design, Setting, and Participants A retrospective case series comprising 4 consecutive outpatients, 22 to 87 years of age, with COVID-19 pneumonia and hypoxemia treated with ramatroban between April and July 2021 in India. Main Outcomes and Measures The primary outcome measure was blood oxygen saturation using pulse oximetry (SpO2). Secondary outcome measures were respiratory distress and need for hospitalization. Results Four COVID-19 outpatients had developed progressive respiratory distress and hypoxemia. Within 12-36 hours of the first dose of ramatroban, all four patients experienced increase in SpO2 and decrease in respiratory distress, which obviated hospitalization. Continued treatment for 5 days was associated with complete resolution of respiratory distress and hypoxemia. Conclusions and Relevance There is an unmet medical need for drugs that target the hemodynamic, prothrombotic, and maladaptive immune responses that lead to pneumonia and respiratory failure following SARS-CoV-2 infection. As an anti-vasospastic, broncho-relaxant, anti-thrombotic and immunomodulatory agent, ramatroban addresses the fundamental host response mechanisms underlying respiratory and critical organ failure in COVID-19. Ramatroban merits study in randomized clinical trials that might offer hope for a cost-effective pandemic treatment.
Biomimetic non-classical crystallization induced hierarchically structured efficient circularly polarized phosphors
Authors: Yao Hong-Bin , Feng Li-Zhe , Wang Jing-Jing , Ma Tao , Yin Yi-Chen , Song Kuang-Hui , Li Zi-Du , Zhou Man-Man , Jin Shan , Zhuang Taotao , Fan Fengjia , Zhu Manzhou
Published: January 2022

Hierarchically structured chiral luminescent materials hold promise for achieving efficient circularly polarized luminescence. However, a feasible chemical route to fabricate hierarchically structured chiral luminescent polycrystals is still elusive because of their complex structures and complicated formation process. We here report a biomimetic non-classical crystallization (BNCC) strategy for preparing efficient hierarchically structured chiral luminescent polycrystals using well-designed highly luminescent homochiral copper(I)-iodide hybrid clusters as basic units for biomimetic crystallization. By monitoring the crystallization process, we unravel the BNCC mechanism, which involves crystal nucleation, nanoparticles aggregation, oriented attachment, and mesoscopic transformation processes. We finally obtain the circularly polarized phosphors with both high luminescent efficiency (32%) and high luminescent dissymmetry factor (1.5 × 10-2), achieving the first demonstration of a circularly polarized phosphor converted light emitting diode with a polarization degree of 1.84% at room temperature. Our designed BNCC strategy provides a simple, reliable and large-scale synthetic route for preparing bright circularly polarized phosphors.
Inflammatory Myofibroblastic Tumor in the Inguinal canal: A Rare Case Report
Authors: Patel Arpankumar , Desai Rutikbhai , Shah Hilloni , Vaisyambath Laseena , Karri Manozna , Peela Appala , Koritala Thoyaja
Published: January 2022

Background

Inflammatory myofibroblastic tumors, previously known as inflammatory pseudotumors, are rare soft tissue carcinomas with variable presentation and location. Due to non-specific symptoms and location, the diagnosis of this condition is often clinically challenging. Only a handful of case reports have been published in the literature describing this tumor, and there is still a lack of consensus on pathogenesis, risk factors, and treatment strategy. Most tumors have shown mutation in the anaplastic lymphoma receptor tyrosine kinase (ALK) gene. In this article, we describe a case of ALK-negative malignant inflammatory myofibroblastic tumor.

Case

A 46 years old male with no risk factors presented with a mass in the inguinal region. The ultrasound was suggestive of a mixed echoic mass suggestive of inguinal hernia, which led to surgical repair with resection of the tumor segment. Subsequently, histopathology and immunohistochemistry confirmed that the mass was an inflammatory myofibroblastic tumor which then recurred in a few years and failed to respond to multiple chemotherapy regimens, and over time, it progressively metastasized to the anterior abdominal wall and lungs. The patient is currently receiving palliative chemotherapy and symptomatic treatment.

Conclusion

This rare soft tissue tumor has not received much attention, and clinicians often miss the diagnosis. We stress that further study should be carried out on these soft tissue tumors, and adequate diagnostic and therapy recommendations should be developed.
A cross-sectional study assessing the alarming prevalence of burnout among physicians in a developing country facing a combination of a COVID-19 Pandemic and an economic collapse
Authors: Youssef Dalal , Youssef Janet , Abou-Abbas Linda , Kawtharani Malak , Hassan Hamad
Published: January 2022

Background:Burnout among physicians is a serious concern that cultivates its seeds during their education and matures in their daily practicing life. Lebanese physicians were particularly at high risk of burnout since they confronted a mixture of overlapping crises. Objectives: This study aimed to assess the prevalence of burnout among Lebanese physicians and to investigate its associated factors. It targeted also to explore the combined effects of the pandemic and the economic crisis on burnout.Methods:A web-based cross-sectional study was conducted among Lebanese physicians over December 2020 using a snowball sampling technique. Self-reported data were collected electronically through an anonymous questionnaire that included information on socio-demographic characteristics, work-related variables, and 4 scales: fear of COVID-19, threat perception, InCharge Financial Distress/Financial Well-Being, and the Copenhagen burnout inventory (CBI). CBI scale cut-off score of 50 was used to evaluate the prevalence of burnout. Multivariable linear regression analyses were carried out to identify the factors associated with burnout.Results:A total of 398 physicians participated in the study. The majority of them were male (52.8%), married (60.1%), and aged between 40 and 49 years (43.2%).Moderate and High level of burnout hits 90.7% of the Lebanese physicians where personal, work-related, and client-related burnout were detected among 80.4%, 75.63%, and 69.6% of them respectively. A strong association was found between the higher level of burnout and female gender, younger age, being single, having a dependent child, living with an elderly or having a family member with comorbidities, and insufficient sleeping hours. Physicians’ specialties, working in a public health facility, limited years of professional experience, lack of previous experience in pandemic, and extensive working hours were also associated with increased burnout. Furthermore, low income, working in the frontline, higher threat perception, and fear of COVID-19 were contributing to higher burnout. However, financial wellbeing, altruism, having good health, and previous history of COVID-19 were significantly associated to lower burnout. The combined effect of threat perception and financial hardship significantly increased the level of burnout.Conclusion:The huge burnout level detected among Lebanese physicians raises alarm about the seriousness of the current situation and urges the health authorities to take prompt action to enhance the physicians’ wellbeing.
COLLABORATION CLASS TEACHERS AND CONSELORS IN DIRECTING STUDENTS 'CLASS XII HIGH SCHOOL INTERESTS DETERMINING THE CONTINUATION AT SMA NEGERI 1 PATIANROWO
Authors: Septiana Nila Zaimatus , Umatin Choiru
Published: January 2022

Penelitian ini disajikan untuk mengantisipasi langkah ke depan siswa kelas XII dalam mengambil sebuah keputusan mengenai minat yang dimilikinya melalui kolaborasi guru dan konselor. Pengumpulan data dalam penelitian ini menggunakan teknik observasi dan wawancara. Data penelitian ini diperoleh dari guru BK atau konselor SMAN 1 Patianrowo Kabupaten Nganjuk Jawa timur. Analisis data dalam penelitian ini menggunakan analisis naratif. Subjeknya adalah siswa kelas VII SMAN 1 Patianrowo. Temuan ini mengungkapkan bahwa banyak dari peserta didik belum menyadari terkait minatnya. Peserta didik lebih banyak diarahkan dalam hal akademik semata dan belum mengarah pada pengembangan potensi yang dimiliki peserta didik seperti pengarahan terhadap minat peserta didik. Sedikit dari para peserta didik yang dapat mengembangkan minat yang dimilikinya karena guru lebih terfokus pada akademik dan konselor lebih terfokus dalam hal menangani masalah yang dialami oleh peserta didik. Proses kolaborasi guru kelas dan konselor ini dilaksanakan dalam bentuk tercatat dan tidak tercatat. Kolaborasi yang tercatat  seperti  pelaksanaan tes minat bakat yang terjadwal pada kelas X dan kelas XII awal. Sedangkan tidak tercatat seperti komunikasi antara guru kelas dengan Konselor terkait apa yang menjadi minat peserta didik melalui analisis dalam keseharian peserta didik. Hal ini merupakan salah satu upaya untuk mengetahui minat peserta didik sejak dini yang kemudian dipertegas kembali dengan pengadaan tes skolastik pada awal memasuki kelas XII. Dalam mengadakan bimbingan kelompok, konselor menggunakan kesempatan pada waktu luang atau saat terdapat suatu kelas yang sedang tidak dalam proses pembelajaran untuk melakukan bimbingan kelompok di dalam kelas. Sementara untuk bimbingan pribadi, konselor memanggil satu persatu peserta didik. Namun, tidak semua harus di panggil, melainkan banyak dari para peserta didik secara suka rela datang menemui konselor dengan sendirinya untuk melakukan bimbingan.
PENGARUH KOMPETENSI DOSEN DAN VARIASI METODE TERHADAP PRESTASI BELAJAR MAHASISWA
Authors: Jani Jani
Published: January 2022

Penelitian ini dilatar belakangi oleh kemampuan dosen dalam mendorong mahasiswa untuk berprestasi seperti dalam penggunaan metode belajar sesuai dengan kompetensi dasar yang akan dicapai setelah pembelajaran selesai. Namun tidak semua yang dilakukan oleh dosen dapat mendorong mahasiswa untuk berprestasi secara optimal, sebab akan sangat tergantung pula kondisi dosen dan mahasiswa tersebut, seperti nampaknya berbeda antara prestasi mahasiswa jurusan yang satu dengan jurusan yang lainnya. Metode penelitian yang digunakan adalah pendekatan kuantitatif. Lokasi penelitian adalah di Jurusan Tadris IPS IAIN Tulungagung Fakultas Tarbiyah dan Ilmu Keguruan. Populasinya adalah seluruh Mahasiswa Jurusan Tadris IPS Semester Ganjil Tahun Akademik 2017/2018   sebanyak  170  orang. Selanjutnya data yang terkumpul diolah dengan Regresi Berganda Non Parametrik. Hasil penelitian ini menunjukkan bahwa 1) Pengaruh Kompetensi Dosen terhadap Prestasi Belajar  Mahasiswa Semester Ganjil  Jurusan Tadris IPS pada Fakultas Tarbiyah dan Ilmu Keguruan IAIN Tulungagung Tahun Akademik 2017/2018, dibuktikan dari nilai thitung sebesar 2,288 bernilai positif dengan signifikan sebesar 0,023. Karena nilai Sig-t  yaitu 0,023 < 0,05 maka secara parsial variabel kompetensi dosen (X1) berpengaruh signifikan terhadap variabel prestasi belajar mahasiswa (Y) sehingga Ho ditolak dan Ha diterima.  2) Pengaruh Variasi Metode  terhadap Prestasi Belajar  Mahasiswa Semester Ganjil  Jurusan Tadris IPS pada Fakultas Tarbiyah dan Ilmu Keguruan IAIN Tulungagung Tahun Akademik 2017/2018, dibuktikan dari nilai thitung sebesar 2,396 bernilai positif dengan signifikan sebesar 0,018. Karena nilai Sig-t < 0,05 yaitu 0,018 < 0,05 maka secara parsial variabel variasi metode  (X2) berpengaruh signifikan terhadap variabel prestasi belajar mahasiswa  (Y) sehingga Ho ditolak dan Ha diterima.  3) Pengaruh Kompetensi Dosen dan Variasi Metode secara bersama-sama terhadap Prestasi Belajar Mahasiswa Semester Ganjil Jurusan Tadris IPS pada Fakultas Tarbiyah dan Ilmu Keguruan IAIN Tulungagung Tahun Akademik 2017/2018, dibuktikan dari nilai Fhitung 7,307 > Ftabel 4,75 dengan Sig. 0,001. Jadi Sig. diperoleh 0,0001 < 0,05, sehingga Ho ditolak dan Ha diterima
Pembelajaran IPS Dengan Menerapkan Pendekatan Saintifik Tema: Pembelajaran IPS
Authors: Indriyana Afilda Ayu , Khusna Nur Isroatul
Published: January 2022

IPS merupakan disiplin ilmu yang terdiri dari geografi, ekonomi, sosiologi, sejarah dan antropologi. Pada mata pelajaran IPS merupakan salah satu pendidikan yang berupaya untuk mengembangkan pandangan peserta didik tentang manusia sebagai makhluk social yang tidak dapat hidup sendiri dan pasti membutuhkan bantuan  antar sesamanya. Pada pembelajaran IPS memiliki tujuan mengembangkan pengetahuan, sikap dan keterampilan social pada peserta didik guna sebagai bekal untuk hidup bermasyarakat kelak. Pembelajaran IPS sendiri mendorong peserta didiknya supaya memiliki bekal pengetahuan, nilai, moral dan keterampilan untk bisa berperan dalam kehidupan bermasyarakat kelak. Pembelajaran IPS dengan menerapkan pendekatan saintifik ini bertujuan supaya peserta didik bisa lebih aktif.
INDEKS KEPUASAN MASYARAKAT TERHADAP PROGRAM TANGGUNG JAWAB SOSIAL DAN LINGKUNGAN PT KILANG PERTAMINA INTERNASIONAL REFINERY UNIT II DUMAI
Authors: Mulyani Iwed , Raditya Lukas , Fatkhullah Mukhammad
Published: January 2022

Dari berbagai program Tanggung Jawab Sosial yang dilaksanakan PT Kilang Pertamina Internasional Refinery Unit II Dumai, Program Desa Wisata Gambut Sejahtera (DEWIGATRA) menjadi program unggulan yang menyita perhatian. Program ini mewakili kebutuhan masyarakat untuk meminimalisir kerentanan, khususnya kebakaran hutan dan lahan yang terjadi setiap tahunnya. Penelitian ini bermaksud untuk mengukur Indeks Kepuasan Masyarakat terhadap Program TJSL PT KPI RU II DUMAI melalui Program DEWIGATRA. Penelitian ini menggunakan pendekatan kuantitatif deskriptif. Populasi dalam kajian ini adalah anggota kelompok pengelola DEWIGATRA. Adapun teknik pengambilan sampel pada peneitian ini adalah purposive sampling. Teknik pengambilan sampel pada peneitian ini adalah purposive sampling. Dari 14 indikator, 12 aspek mendapatkan penilaian yang memuaskan. Hanya Indikator tentang kemampuan masyarakat untuk melanjutkan program secara mandiri mendapat penilaian “KURANG BAIK”. Namun kinerja program DEWIGATRA mendapatkan predikat "SANGAT BAIK" dengan nilai indeks sebesar 3,5 atau 8,75 setelah dikonversi.
Rumah-Ku, Rumah Doa Segala Bangsa: Telaah terhadap Yesaya 56:1-8 sebagai Hasil Interkultural Israel Paska Pembuangan
Authors: Subowo Adhika Tri
Published: January 2022

AbstractIntercultural is a necessity when we meet other people or other communities. Awareness of building relationships in a spirit of equality. In intercultural encounters, the horizon for culture will experience renewal. Text is also a product of culture, which can also experience intercultural encounters. One of the intercultural texts is Isaiah 56: 1-8. This text is important in intercultural theology because it’s contains a theology that is different from ancient Israel. This research was conducted in order to investigate the intercultural processes that occur in the text of Isaiah 56: 1-8. In order to elaborate on the theme, i will present of the pre-exilic community, the exile community and the post-exil community. The description of the three communities is important in the context of detecting intercultural texts. After becoming clear the intercultural process of the text, the text will be used as a foothold in formulating intercultural missions that are relevant to the church in Indonesia.

AbstrakDalam sebuah perjumpaan dengan individu atau komunitas lain, interkultural adalah sebuah keniscayaan. Kesadaran akan teologi interkultural menjadi penting, dalam rangka membangun kesadaran membangun relasi dalam semangat kesetaraan. Dalam perjumpaan interkultural, horizon terhadap budaya akan mengalami kebaharuan. Teks sesungguhnya juga adalah produk budaya, yang juga bisa mengalami perjumpaan interkultural. Salah satu teks yang mengalami interkultural adalah Yesaya 56:1-8. Teks ini amat menarik karena mengandung teologi yang berbeda dengan Israel kuno. Penelitian ini dilakukan dalam rangka menelisikproses interkultural yang terjadi pada teks Yesaya 56:1-8. Dalam rangka mengelaborasi tema tersebut, maka penulis akan menyajikan gambaran komunitas pra-pembuangan, komunitas pada masa pembuangan dan komunitas paska pembuangan. Gambaran ketiga komunitas tersebut menjadi penting dalam rangka mendeteksi interkultural pada teks. Setelah menjadi terang proses interkultural pada teks, teks tersebut akan dijadikan pijakan dalam merumuskan misi interkultural yang relevan bagi gereja di Indonesia.
Larangan Intermarriage dalam Nehemia 13: 23-27: Suatu Upaya Hermeneutis Post-Modern melalui Pendekatan Sosial-Antropologis
Authors: Nainggolan Dina Maria
Published: January 2022

AbstractThis article is a post-modern hermeneutic study of Nehemiah 13: 23-27 with a socio anthropologicalapproach. This text talks about the prohibition of intermarriage between the Jewish community and foreign nations in the post-exilic era. This prohibition still alive now, not only in the Jewish community but also in other Abrahamic religions. Liquidity of cultural and religious identities today does not mean denying those people who still keep their tradition, culture, and group identities. The latest socio-anthropological and archeologicalstudies of the Bible show the text as Nehemiah and text editor effort to bequeath cultural memories to build the purity of Jewish identity. With intertextual studies, I will show that Old Testament Books is not ‘one voice’ about intermarriages. This ambiguity challenges us to rethink the prohibition on intermarriage without discrimination and segregation to the Other.

Abstrak Artikel ini adalah upaya hermeneu􀆟 s post-modern terhadap teks Nehemia 13:23-27 dengan pendekatan sosio-antropologis. Teks ini berbicara tentang larangan kawin campur (intermarriage) antara komunitas Yahudi pasca-pembuangan dengan bangsa-bangsa asing. Larangan ini nyatanya masih terjadi hingga saat ini, bukan hanya di tengah-tengah komunitas Yahudi masa kini, namun juga agama-agama Abrahamik lainnya. Cairnyaidentitas budaya dan agama saat ini tidak berarti menafikan mereka yang masih memegang teguh tradisi, budaya dan pelestarian identitas kelompoknya. Studi sosio-antropologis dan arkeologi Alkitab terbaru memperlihatkan teks sebagai upaya Nehemia maupun redaktur teks mewariskan ingatan budaya dalam rangka membangun kemurnian identitas bangsa Yahudi pasca-pembuangan. Penulis juga memanfaatkan studi intertekstual dalam rangka memperlihatkan bahwa kitab Perjanjian Pertama (PP) tidak unisono dalam memperlihatkan larangan intermarriage. Ambiguitas ini menjadi tantangan bagi kita untuk memikirkan ulanglarangan intermarriage tanpa diskriminasi dan segregasi terhadap mereka yang berbeda.
Responsiveness of rural development to budget management attributes: Evidence from Ogun State, Nigeria
Authors: Egbide Ben-Caleb , Madugba Joseph , Otekunrin Adegbola , Adenike Oladipo , Oludare Fadoju
Published: January 2022

The essence of local government as contained in the Nigerian Constitution is bringing government closer to the people and make them feel the impact of governance. This study examined the responsiveness of rural development to three of the attributes of public budgeting (effectiveness, openness, and adequacy) in selected local governments in Ogun State, Nigeria. The objective was to establish the functional association and interconnectedness between the explained and explanatory variables. Data were gathered through the administration of a five-point Likert scale questionnaire distributed to 800 respondents in 8 local governments in Ogun States, out of which 348, representing 43.5%, were retrieved and used for analysis. Both descriptive statistics and ordinary least square regression were utilized in the study. The result showed that three explanatory variables, namely budget effectiveness, budget openness, and budget adequacy, are positively related to rural development, although the impact of budget adequacy was shown to be insignificant. The implication is that the effectiveness of budget management and the openness of the budget in terms of transparency and accountability are more responsive and influential determinants of rural development than the adequacy of the budget estimates. The paper, therefore, recommended improvement in budget openness through more consultations and accessibility to budget information by the public as well as monitoring of projects and programs within the local council to engender development and add value to the rural dwellers.
In the Name of Traditions: A Comprehensive Study on the Impact of Female Genital Mutilation (FGM) on Women and Girls An Overview of Female Genital Mutilation (FGM) in Iran
Authors: AHMADY Kameel
Published: January 2022

A comprehensive study was undertaken to investigate, explore and analyse the existence of female genital mutilation/cutting (FGM or FGM/C) in Iran. The timespan of this study began in 2005 and ended in 2014. The aim of this study was to provide in-depth data on FGM in Iran and, at the same time, provide the building blocks for a comprehensive programme to combat FGM in Iran and bring this issue onto the world’s agenda. The methodological approach adopted by this study was primarily participatory, due to the sensitivity of the subject matter. Most parts of this research were completed by the end of 2014, and much has been achieved over a decade of studying the subject of FGM in Iran.The study included travelling thousands of kilometers and interviewing over 3,000 women and 1,000 men from various areas and social classes, including key role players, community leaders, clerics and religious leaders in order to compile comprehensive data about the practice of FGM in Iran. The findings demonstrate that FGM in some locations is widespread among women and girls (around 60% in some villages of Qeshm Island in the southern province of Hurmozgan, especially in the villages of the four provinces in the north-west, west and south of Iran). FGM was not, however, practised in the northern parts of West Azerbaijan, where people are Turkish Azeri and Kurmanji Kurdish speakers, nor in the southern parts of Kermanshah and northern parts of Hormozgan.This research study, along with a short documentary film, has gained global recognition and was launched by The Guardian and the BBC on 4 June 2015 through their websites. Shortly thereafter it was discussed at a United Nations meeting of the Human Rights Council in Geneva, on 19 June 2015 at a session on eliminating FGM. Reuters also published an analysis of the research and considered it one of the rare contributions in the history of Iran.
The effect of anaerobic co-fermentation on acidification performance of food waste and cardboard waste
Authors: Shiyan Gu , Wenyi Zhang , Huige Xing , Ruji Wang , Jiyang Sun , Min Zhang , Yi Li
Published: January 2022

The fermentation system with high solid materials for food waste (FW) is uneven in nutrition and easy to produce volatile acid accumulation, which causes the reaction system to acidify and affects the normal operation of fermentation. This study evaluated the effect of the co-substrate percentages (FW:CB = 9:1, FW:CB = 8:2, FW:CB = 7:3) and the initial total solid contents (12%, 15%, 18%) on the co-fermentation acidification performance of FW and cardboard waste (CB). The maximum methane production was obtained when mono-fermenting FW had high solids contents (1.4 L/kg). The methane production increased and then decreased with the increasing percentages of CB. Under the conditions of FW:CB = 8:2, the maximum methane production could reach 3.4 L/kg. The lower methane production (1.8 – 2.5 L/kg) with high percentages of CB (FW:CB = 7:3) was translated into higher yields of caproic acid (up to 26%), which indicated that lower percentages of CB had a stabilization effect due to the higher buffering capacities in co-fermentation. As a result, this study demonstrated new possibilities for using CB percentages to control the production of high added-value biogas in dry co-fermentation of FW.
Impacto psicologico de la pandemia COVID-19 en adultos residentes en Carabayllo
Authors: Ochoa Maza Alondra , Flores Solorzano Shirle , Villarreal Lora Kristell
Published: January 2022

Objetivo: El objetivo de esta investigación fue determinar el impacto psicológico de la pandemia COVID-19 en adultos que residen en una zona de Carabayllo. Materiales y métodos: El presente estudio fue de enfoque cuantitativo y su diseño metodológico, descriptivo y transversal. La población de estudio estuvo constituida por 300 personas. La técnica de recolección de datos fue la encuesta y el instrumento de medición las escalas DASS-21 que valoran depresión, ansiedad y estrés, que presentan 21 ítems. Resultados: Los resultados obtenidos del impacto psicológico por la pandemia de la COVID-19 indican que el 59,3% (n=188) son normales, un 13,6% (n=43) moderado, un 11,4% (n=36) extremadamente severo, un 10,4% (n=33) severo y un 5,4% (n=17) leve. En la dimensión de depresión predominó un 57,4% (n=182) con valores normales, en la dimensión de ansiedad predomino el 55,5% (n=176) con valores normales y por último en la dimensión de estrés predomino el 61,5% (n=195) con valores normales. En general. Aproximadamente un 20% de la población participante presenta valores entre severo y extremadamente severo. Conclusiones: En las personas adultas participantes en el estudio en relación al impacto psicológico, predomino el valor normal y en todas sus dimensiones también predomino el valor normal. A pesar de estos resultados, se evidencia que un porcentaje menor participantes se encuentran amenazados en su salud emocional que viene siendo afectada en este escenario de pandemia por la COVID-19, a su vez, se recomienda darle un abordaje inmediato en la cual se incluyan cuidados que contrarresten este problema.
Riesgo familiar total durante la pandemia por coronavirus en familias que reciben asistencia alimentaria en Carabayllo
Authors: Guzman Cuadros Maria Vanessa
Published: January 2022

Objetivos: Determinar el riesgo familiar total durante la pandemia por coronavirus en familias que reciben asistencia alimentaria en Carabayllo. Materiales y métodos: El enfoque fue cuantitativo y el diseño descriptivo-transversal. La población estuvo conformada por 336 integrantes de familias que reciben asistencia alimentaria durante la pandemia COVID-19. Se empleó el cuestionario Riesgo Familiar Total (RFT 5:33), que consta de 33 ítems y 5 dimensiones. Resultados: En cuanto al riesgo familiar total, 61,6% (n=207) de las familias tenían un riesgo bajo, seguido de 23,8% (n=80) de familias amenazadas y 14,6% (n=49) de familias con riesgo alto. En cuanto a las dimensiones, en condiciones psicoafectivas, el 87,8% (n=295) fueron familias amenazadas, seguido de 12,2% (n=41) de familias con riesgo alto; en servicios y prácticas de salud, el  81,3% (n=273) eran familias amenazadas, seguido de 18,8% (n=63) de familias con riesgo alto; en condiciones de vivienda y vecindario, un 87,2% (n=293) eran familias amenazadas, seguido de 12,8% (n=43) de familias con riesgo alto; en situación socioeconómica, un 73,8% (n=248) eran familias amenazadas, seguido de 26,2% (n=88) de familias con riesgo alto; finalmente, en manejo de menores, el 87,5% (n=294) eran familias amenazadas, seguido de 12,5% (n=42) de familias con riesgo alto. Conclusiones: En cuanto al riesgo familiar total, predomino las familias con riesgo bajo, seguido de amenazadas y riesgo alto. En relación a las dimensiones, en todas predominaron las familias amenazadas.
Composición química del aceite esencial de Aloysia Triphylla "cedrón" como insumo para la elaboración de un enjuague bucal
Authors: Huerta León Jenny Rosalyn , Samaniego Joaquin Jhonnel Williams , Fuertes Ruitón Cesar Máximo
Published: January 2022

Objetivo: Determinar la actividad antimicrobiana del aceite esencial obtenidos de las hojas y tallos de Aloysia triphylla “cedrón” provenientes de la ciudad de Huaraz, departamento de Ancash, distrito de Mancos. Materiales y métodos: Se utilizó el método de hidrodestilación por arrastre de vapor para la obtención del aceite esencial y para la determinación de la actividad antibacteriana se realizó por la metodología de difusión de agar frente a Streptococcus mutans ATCC 25175 y Porphyromonas gingivalis ATCC 33277 comparándolas con un control positivo el cual era un enjuague bucal comercial de clorhexidina al 0,05%. Resultados: Se obtuvo un rendimiento del 0,11 y en el estudio microbiológico se obtuvieron halos de 21,3 mm del aceite esencial y 19,9 mm del control positivo frente a Streptococcus mutans ATCC 25175 y de 35,5 mm en el aceite esencial y 25,4 mm del control positivo frente a Porphyromonas gingivalis ATCC 33277. Conclusiones: Se concluye que, que la actividad antimicrobiana que demostró el aceite esencial de Aloysia triphylla (cedrón) es superior al control positivo que fue un enjuague bucal comercial de clorhexidina al 0,05%, pudiendo este ser usado como fuente en la elaboración de preparaciones farmacéuticas en el tratamiento de infecciones causadas por estos microorganismos.
A Randomized, Single Centered, Parallel and Open Labelled Interventional
Study on Effectiveness of Clinical Pharmacists on Adverse Event Following
Immunization (AEFI) in Pediatric Population
Authors: Wali Shashikala C. , Arvind Ronit K. , Beerwala Faizan A. , Parihar Ashish S. , Ganachari Madiwalayya S. , Bhandari Ramesh
Published: January 2022

Background:

Adverse events are a major threat to any immunization programs, which
have proven to be a boon for developing nations like India. Hindering factors, such as inadequate
knowledge, inappropriate attitude, incorrect practices, etc., of the guardian affect the vaccination
rate.

Aim:

This study aims to assess the effectiveness of clinical pharmacist intervention on an adverse
event following immunization in the pediatric population receiving immunization.

Materials and Methods:

Pediatric subjects <5 yrs of both genders receiving immunization in a tertiary
care hospital during the period of 8 months were considered. Subjects were randomized into
control and interventional groups. Pharmaceutical intervention was done in interventional group in
the form of patient counselling, and a patient information leaflet. Adverse event following immunization
was recorded and analysed for both groups along with Knowledge, Attitude, and Practice
scores of guardians’ pre and post intervention through customized data collection forms. Microsoft
excel and statistical software SPSS IBM version 22 was used to analyse the data.

Results:

The study was conducted on a total of 88 subjects (n) in which 79 were <2 years, 1 and 8
were between 2-4 years and 4-5 years, respectively. Forty-nine subjects (55.69%) were female,
while 39 were male (44.31%) with a response and completion rate of 91.66%. 97.7% of subjects received
Bacillus Calmette-Guerin vaccination (majority), while 8.88% received pneumococcal special
vaccine (minority). Adverse event following immunization was recorded in 31(35.22%) cases.
Knowledge, Attitude and Practice scores increased by 42.17%, 52% and 12.67%, respectively in
guardians after clinical pharmacist intervention.

Conclusion::

This study demonstrates that educational inputs, awareness programs, and proper medical
professional intervention can act as a helping factor to fight against AEFI and towards the success
of an immunization program.
American Association of Clinical Endocrinology And Associazione Medici Endocrinologi Thyroid Nodule Algorithmic Tool
Authors: Garber Jeffrey R. , Papini Enrico , Frasoldati Andrea , Lupo Mark A. , Harrell R. Mack , Parangi Sareh , Patkar Vivek , Baloch Zubair W. , Pessah-Pollack Rachel , Hegedus Laszlo , Crescenzi Anna , Lubitz Carrie C. , Paschke Ralf , Randolph Gregory W. , Guglielmi Rinaldo , Lombardi Celestino P. , Gharib Hossein
Published: January 2022

Objective: The first edition of the American Association of Clinical Endocrinology/American College of
Endocrinology/Associazione Medici Endocrinologi Guidelines for the Diagnosis and Management
of Thyroid Nodules was published in 2006 and updated in 2010 and 2016. The American Association of
Clinical Endocrinology/American College of Endocrinology/Associazione Medici Endocrinologi multidisciplinary
thyroid nodules task force was charged with developing a novel interactive electronic
algorithmic tool to evaluate thyroid nodules.

Methods: The Thyroid Nodule App (termed TNAPP) was based on the updated 2016 clinical practice
guideline recommendations while incorporating recent scientific evidence and avoiding unnecessary
diagnostic procedures and surgical overtreatment. This manuscript describes the algorithmic tool
development, its data requirements, and its basis for decision making. It provides links to the web-based
algorithmic tool and a tutorial.

Results: TNAPP and TI-RADS were cross-checked on 95 thyroid nodules with histology-proven diagnoses.

Conclusion: TNAPP is a novel interactive web-based tool that uses clinical, imaging, cytologic, and molecular
marker data to guide clinical decision making to evaluate and manage thyroid nodules. It may be
used as a heuristic tool for evaluating and managing patients with thyroid nodules. It can be adapted to
create registries for solo practices, large multispecialty delivery systems, regional and national databases,
and research consortiums. Prospective studies are underway to validate TNAPP to determine how it
compares with other ultrasound-based classification systems and whether it can improve the care of
patients with clinically significant thyroid nodules while reducing the substantial burden incurred by
those who do not benefit from further evaluation and treatment.
influence of word of mouth and brand image on the consumer decision process in choose clinic content
Authors: Ramadhayani B Rulli , Wahab Zakaria , Widiyanti Marlina , Rosa Aslamia
Published: January 2022

This study aimed to analyze the effect of word of mouth and brand image jointly and partially on consumer decisions and the dominant two variables. Data collection at the Embun Pagi Clinic in the Sekayu area involved 100 patients who used the services of the Sekayu Embun Pagi Clinic with non-probability sampling, namely accidental sampling. Data was collected by distributing questionnaires and using multiple linear regression using SPSS software. Data analysis is a descriptive method, classical assumption test with normality test with Kolmogorov-Smirnov, multiple regression analysis methods with f test, t-test, and coefficient of determination. This study indicates that word of mouth and brand image significantly influence the consumer decision process in choosing the Embun Pagi Sekayu Gynecological Clinic. These results can be seen in the multiple regression analysis and the coefficient of determination R-value of 0.802, meaning that the relationship between word of mouth and brand image on consumer decisions is 80.2%, meaning that the relationship between variables is close. Adjusted R Square value of 0.636 means that 63.6% of purchasing decision factors can be explained by word of mouth and brand image.
Poverty as the impact of the COVID-19
Authors: Limbong Sukanto , Siallagan Senada
Published: January 2022

This is an ethnography study which aimed to find out the real condition of poverty in Indonesia. Preliminary study showed that there are massive social impacts in the new normal due to COVID-19. There are three kinds of poverty that can be seen in real terms namely extreme poverty, absolute poverty, and relative poverty. Moreover, when viewed from the biblical approach, there are two words used that helped us in our  research on poverty, namely "race” = “poor people" and "dal” which is more translated as “weaker” than “poor”. The Bible does not state a single view on poverty but mentioned some Bible passages. The first is idleness poverty. This poverty is caused by laziness or negligence over personal responsibility to look for means to meet needs. The Bible uses ants as an opposite example of laziness in the book of Proverbs 6:6. The second is theodise poverty. This poverty is illustrated by Job who was stripped off of his riches, yet he was able to accept and embrace whatever the Lord gave to him.
Metodologia de análise dos riscos em áreas de ocorrência de carste urbano: estudo aplicado ao município de João Pessoa, Estado da Paraíba - Brasil
Authors: Santos Caio Lima dos , Girão Osvaldo , Vital Saulo Roberto de Oliveira
Published: January 2022

O presente manuscrito tem por objetivo propor um método de análise dos riscos relacionados ao relevo cárstico em área urbana, que tem como princípio a abordagem de todos os elementos componentes do sistema cárstico urbano, de forma integrada. Considera-se, portanto, os aspectos relativos à dinâmica física natural, bem como os aspectos relativos à dinâmica urbana. Sendo assim, o desenvolvimento deste trabalho consiste na descrição do referido procedimento metodológico.  Indica-se sua adoção no que tange os estudos dos riscos em ambientes cársticos em área urbana. Destarte, considerar e correlacionar a dinâmica evolutiva do relevo cárstico e as interferências antrópicas na formação de áreas de risco cárstico torna-se essencial.
De meerwaarde van botscintigrafie bij honden met ongedefinieerd manken achteraan of niet-gelokaliseerde pijn op de achterhand
Authors: De Wilde N. , Peremans K.
Published: January 2022

Botscintigrafie is een zeer gevoelige techniek om vroege veranderingen in de metabole activiteit van botstructuren weer te geven, zoals verhoogde bloedperfusie en/of verhoogde botremodellering. Botscintigrafie is uiterst geschikt als gevoelige diagnostische tool in het mankheidsonderzoek van de hond maar moet wegens de beperkte specificiteit gecombineerd worden met structurele beeldvormingstechnieken. In deze retrospectieve studie werden 194 patiënten opgenomen die mankten op de achterpoten en/of pijn vertoonden op de achterhand in de periode van 2001 tot en met 2020. Vierenzestig honden werden in de studie ingesloten op basis van patiëntengegevens. Bij de geselecteerde honden werden de bevindingen van de botscintigrafie vergeleken met de vaststellingen op andere beeldvormingsmodaliteiten die eventueel vooraf uitgevoerd werden en met de beeldvorming die achteraf gebeurde op basis van de scintigrafiebeelden. Uit deze retrospectieve studie kan besloten worden dat botscintigrafie zijn nut bewijst bij aandoeningen, waarbij het voorgaande onderzoek niet conclusief was.
Whole-body thermal therapy as adjuvant therapy to radiation in a dog with metastasized anal sac adenocarcinoma
Authors: Janssen S. , Wylleman B. , Kromhout K. , Benoit J. , Marynissen S. , Van de MAele I. , De Rooster H.
Published: January 2022

An eleven-year-old Galgo Espagnol was diagnosed with metastasized anal sac adenocarcinoma. The patient was enrolled into a clinical trial and underwent three “whole-body thermal therapy” (WBTT) sessions combined with four hypofractionated radiotherapy sessions during a ten-weeks’ time period. The medical device and corresponding treatment protocol were designed by ElmediX (ElmediX NV, Belgium). Air was injected at high speed in a treatment chamber and automatically regulated to reach and maintain a body temperature of 41.5°C for eight hours. Thermometry was ensured by temperature sensors placed in and on the patient. During four radiotherapy sessions, an external beam delivered hypofractionated doses of 6Gy on both the primary tumor and the metastatic lymph nodes. Clinical monitoring and assessment of quality of life confirmed that the WBTT sessions were well tolerated. Although burn wounds at pressure points occurred, prolonged severe adverse effects were not observed. Furthermore, the disease progression was deemed slower than the expected progression based on the literature.
Aderlaten: bloed evacueren
Authors: Devriese L. , Van der Meeren C. , De Smet J.
Published: January 2022

Bloed ‘laten’ is een van de oudste en meest toegepaste medische en veterinaire praktijken. Het ontstaan ervan is vermoedelijk te vinden in het geloof in magie. Het gewone volk was er diep van overtuigd dat geheimzinnige magische krachten in het lichaam oorzaak waren van ziekte. Het ‘kwaad’ (ziek) bloed moest zoveel mogelijk uit het lichaam verwijderd worden. Om de praktijk te rechtvaardigen, hielden universitair geschoolde artsen het bij de Grieks-Latijnse leer van onevenwicht (dyscrasie) in de lichaamsvochten. In de negentiende eeuw werd de vermeende dyscrasie vervangen door theorieën die de rol van ontsteking beklemtoonden. Bloed met ‘ontstekingsstoffen’ moest geëlimineerd worden. Tegen het einde van die eeuw had ook deze interpretatie krediet verloren en aderlaten verdween stilaan uit de praktijk, eerst uit de humane, pas later en schoorvoetend uit de diergeneeskunde, in die tijd nog vooral uitgeoefend door hoefsmeden – of slachters-veeartsen (maréchaux-vétérinaires). Aan de hand van een dagboek bijgehouden van 1853 tot 1887 door een hoefsmid-veearts wordt aangetoond hoe aderlating tot in het laatste kwart van de negentiende eeuw frequent toegepast werd bij allerhande inwendige aandoeningen van runderen. Aansluitend bij dit verhaal over de achtergronden van aderlaten worden de toegepaste technieken kort beschreven.
Runderen versus paardachtigen in de vroeg-West-Europese geschiedenis
Authors: Devriese L.
Published: January 2022

Traditioneel wordt in onze geschiedenis een grote rol toebedeeld aan het paard als oorlogsinstrument en daarmee ook als middel om streken te veroveren en te koloniseren. Domesticatie van deze diersoort zou ervoor gezorgd hebben dat stammen die de paardrijkunst beheersten, dominant werden in onze streken. Minstens zo belangrijk echter, indien al niet meer, is de domesticatie van het rund. Die zorgde voor een extra voedselbron doordat, voor de mens onverteerbare planten, in hoofdzaak grassen, door runderen omgezet worden in voedzaam vlees en melk. Hun melkproductie, hoe gering ook, gaf een selectief voordeel aan mensen die de genetisch gedetermineerde eigenschap lactosetolerantie bezaten. Dit vinden we nu nog weerspiegeld in de prevalentie ervan in de huidige bevolking. In het tweede deel wordt de belangrijke rol van paarden in Noordwest-Europa als trekkracht geïllustreerd.
Transferable skills perception analysus of vocational teachers on-in-on-in dual skills program
Authors: Purnomo Purnomo , Marsono Marsono , Tuwoso Tuwoso
Published: January 2022

The Ministry of Education and Culture in 2016 made one of the breakthrough programs in an effort to organize and fulfill productive teachers in Vocational High Schools (VHS), namely through the Dual Skills Program (DSK). The DSK is implemented to support the improvement of vocational education as well as education and job skills training. Meanwhile, DSK participating teachers must have new competencies that can be used to teach productive subjects in certain areas of expertise. Increasing the competence of DSK participants needs to take into account the development of transferable skills obtained after conducting training or in the process of implementing DSK. The aims of this study are to 1.) Determine the types of transferable skills that DSK participant teachers need to possess; and 2.) Analyze and describe the transferable skills of teachers of vocational high school on-in-on-in DSK in Malang Regency. This study uses a quantitative approach. The samples used were all vocational high school teachers who took part in the on-in-on-in DSK in Malang Regency, while the respondent's data collection used a questionnaire. The results showed that the types of transferable skills consist of communication skills, planning skills, interpersonal skills, work attitude skills, organizational skills, financial management skills, and critical thinking skills. The transferable skills of teachers of vocational high school on-in-on-in DSK in Malang Regency were in a good category.
Integrative adoption model for personal health records: A structural equation modeling approach
Authors:   Department of Information Systems and Technology, College of Computer Science and Engineering, University of Jeddah, Jeddah, Saudi Arabia, Alharbey Riad
Published: January 2022

The adoption of a personal health record (PHR) is a crucial element in quality healthcare, allowing patients to permit the storage of their health information to create a more inclusive, reliable health record. However, the embracing of PHRs has been slow compared to other healthcare-related systems due to the poor design and behavioral aspects. The objective of this research is to study user acceptance factors to identify a better design for PHR systems and to promote healthy behaviors that support individuals' performance. The study proposes an integrative adoption model for PHRs that integrates theoretical factors from the health belief model with the user acceptance determinants from the technology acceptance model and innovation diffusion theory. Using structural equation modeling with the R “Lavaan” package, the study tested the hypothesis relationships of the constructs. The data were captured from individuals through Amazon’s MTurk. Among the nine relationships studied, the research revealed six significant relationships that inform the final PHR integrative adoption model. The research provides great insights into the factors that influence individuals’ PHR adoption. The results introduce a novel integration model to the current body of knowledge. This model will contribute to a better theoretical understanding of the actual use of healthcare-related technologies and bring greater estimates of patient engagement in healthy activities.
Investigation for utilization of training resources in technical education: A comparative study
Authors:   Planning and Development Deputyship, Jubail Technical Institute, Education Sector, Royal Commission for Jubail, Jubail Industrial City, Saudi Arabia, et al. Al-Githami
Published: January 2022

This research study presents a comparative study between the quarter and the semester systems in the technical institutes, in terms of scheduling, training, and utilizing the training resources such as classrooms/halls capacity and employing the instructors. The size of the study sample was represented by the total number of students in classrooms/halls for the study courses in the quarter system by 8836 students distributed over 363 sections. While in the semester system 10360 students distributed over 358 sections. Thus, a comparison was made based on one training year between the two training systems for basic skills courses. The samples were used to know the effect of class capacity and teaching loads on the training system by making initial comparisons, and statistical tools were used where averages of class capacity and teaching loads were calculated to know the status and trends of the data using the plot box. In addition to descriptive statistics (Two samples F-test for variance) and finally, (t-test: Two samples assuming unequal variance) were selected. The p-value less than 0.05 of single-tailed confirmed that classroom capacity and instructors’ load were higher in the semester system compared to the quarter system.