bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Crystal Structures Investigations and Hirshfeld Surface Analysis of Novel Molecule 2, 5-Dihydro [2]Benzopyrano [3,4-c] Pyrazole-water (1/4)
Authors: CS Shripanavar
Published: January 2024

2,5-dihydro[2]benzopyrano[3,4-c]pyrazole-water (1/4) has been novel and newly synthesized nucleus has till date never been reported earlier, it has crystallized in reddish bipyramidal shape, further its need to determine the site of action of these kind of molecules, followed by its detailed X-ray crystal structure were studied. Crystal structure was solved by direct method and refined by full matrix least squares procedure. The crystal structure was stabilized by elaborate system of O-H…N, N-H…O, N-H…N and C-H…O hydrogen bonds along with π-π interactions. 3D Hirshfeld surfaces and allied 2D fingerprint plots were analyzed for molecular interactions.
A Voltammetric Biosensor Based on Glassy Carbon Electrode Modified with DsDNA/ZIF-8/CNT for Determination of Malathion
Authors: RM Masoud
Published: January 2024

In this work, we constructed an electrochemical biosensor based on a glassy carbon electrode modified by dsDNA/ZIF-8/CNT for sensitive and selective measurement of malathion (MAL). First, we investigated the interaction between MAL and salmon sperm dsDNA by computational (molecular docking) and experimental (UV-visible spectroscopy, and electrochemistry) methods. Then, we prepared the ZIF-8/CNT sensor and immobilized dsDNA on it. The ZIF-8/CNT was characterized by fourier transform infrared spectroscopy, X-ray scattering spectroscopy, and field-emission scanning electron microscopy. We optimized the factors affecting the electrochemical response of MAL and immobilization of the dsDNA on the surface of ZIF-8/ CNT/GCE, such as microliter of ZIF-8/CNT, concentration of the dsDNA and the time required for immobilization of dsDNA on the surface of ZIF-8/CNT-GCE, the effect of buffer pH on the MAL accumulation, the effect of MAL accumulation time, and the effect of pH the measurement solution. After optimizing the effective parameters, we drew the calibration curve using the differential pulse voltammetry (DPV) technique and obtained the concentration range of 0.20-50.00 μM with a detection limit of 1.0 nM. Furthermore, the RSD% for five consecutive tests of 2.00 μM MAL was obtained 2.4%. Also, the dsDNA/ZIF-8/CNT sensor showed good recovery in fruit samples.
Nadir and Finical-Minimally Invasive Adenocarcinoma Lung
Authors: A Bajaj
Published: January 2024

Minimally invasive adenocarcinoma emerges as a miniature, solitary, localized, primary pulmonary adenocarcinoma ≤ 3.0 centimetre magnitude and ≤ 0.5 centimetre zone of stromal invasion or non-invasive (lepidic) pattern of neoplastic evolution. Minimally invasive adenocarcinoma lung is predominantly comprised of non-mucinous component and is confined within peripheral pulmonary parenchyma. Preponderantly asymptomatic, poorly defined areas appear concurrent with lepidic pattern of tumour growth whereas solid foci are concordant with focal tumour invasion. Cogent histopathological subtypes appear as non-mucinous variant, mucinous variant and mixed variant. Stromal invasion configures acinar, papillary, micropapillary, solid, colloid, foetal or invasive mucinous lesions. Neoplastic cells appear immune reactive to CK7, thyroid transcription factor1(TTF-1) or Napsin A and immune non-reactive to p40. Minimally invasive adenocarcinoma lung requires segregation from neoplasms such as invasive pulmonary adenocarcinoma, lepidic predominant pattern, adenocarcinoma in situ or atypical adenomatous hyperplasia lung. The gradually progressive neoplasm demonstrates ‘ground glass’ opacities. Appropriate neoplastic discernment necessitates comprehensive histological assessment of entire surgical resection specimens. Minimally invasive adenocarcinoma lung can be appropriately treated with surgical extermination of the neoplasm followed by extensive monitoring. Neoplasm is devoid of lymphatic invasion, vascular invasion, tumour necrosis or pleural invasion.
The Mutant Menage- Mit Family Translocation Renal Cell Carcinoma
Authors: A Bajaj
Published: January 2024

Microphthalmia associated transcription factor (MiT) family translocation renal cell carcinoma is neoplasm which enunciates genetic fusions within members of MiT family of transcription factors, especially TFE3 gene and TFEB gene. Neoplasm frequently incriminates the adult population ≤ 35 years of age with an intense female predilection. Tumefaction exhibits a papillary, solid or alveolar pattern of tumour configuration and is composed of clear cells or non-cohesive, pseudo stratified, eosinophilic epithelial cells. Tumour cells are pervaded with voluminous cytoplasm and pleomorphic nuclei of advanced grade. Neoplastic cells are intensely immune reactive to TFE3 or TFEB, PAX8, cathepsin K, CD10, alpha methyacyl CoA racemase (AMACR), vimentin or E-cadherin. Tumour cells appear immune non-reactive to cytokeratin, epithelial membrane antigen (EMA), carbonic anhydrase IX(CAIX), CD45, calretinin and smooth muscle actin(SMA). MiT family translocation renal cell carcinoma requires segregation from neoplasms such as clear cell papillary renal cell carcinoma, clear cell renal cell carcinoma, epithelioid angiomyolipoma, chromophobe renal cell carcinoma or papillary renal cell carcinoma. Neoplasm may be appropriately alleviated by cogent manoeuvers as surgical extermination of the neoplasm.
Phenotypic Variation in Two Wild Radishes: Raphanus pugioniformis and Raphanus raphanistrum in Field and Common Gardens in Palestine
Authors: Hijawi Thameen
Published: January 2024

A study was conducted to explore phenotypic variation in two Raphanus species: Raphanus raphanistrum and R. pugioniformis, which are found in the East-Mediterranean region. For each species, a 100m2 area representing their respective habitats was selected. Morphological characterization of the whole plant, leaves, and fruits was carried out in the field. The study analyzed morphological characteristics of R. pugioniformis populations during both flowering and maturity stages. It also compared the maturity stage characteristics. The examined characteristics included plant height, flower to plant ratio, leaf to plant ratio, leaf length, flower color, tip to pod ratio, seed to fruit ratio, fruit parameters (length, width, and weight), and the number of primary and secondary branches. Results revealed that plant height, tip to pod ratio, and fruit length increased from the flowering stage to the maturity stage. However, the number of primary and secondary branches and the ratio of seeds to fruit remained consistent between the flowering and maturity stages. R. raphanistrum exhibited greater plant height, flower to plant ratio, leaf to plant ratio, tip to pod ratio, seed to fruit ratio, fruit length, fruit width, fruit weight, and number of branches. The study examined also the dry weight and nitrogen, phosphorous, and potassium contents in leaves, stems, and seeds. It was found that R. pugioniformis had higher nitrogen and phosphorous contents in the leaves, stem, seeds, and whole plant compared to R. raphanistrum. R. pugioniformis exhibited higher nitrogen and phosphorous contents in the leaves, seeds, and whole plant. Similar trends were observed for potassium content. In summary, the study highlighted the phenotypic variation between R. raphanistrum and R. pugioniformis populations in the East-Mediterranean region. Differences were observed in various morphological characteristics, dry weight, and nutrient contents, providing valuable insights into the contrasting traits and adaptations of these closely related Raphanus species.
Cancer Registry Survival Data for Metrics of Continuous Quality Improvement and Quality Assurance
Authors: RO Dillman
Published: January 2024

Purpose: The purpose of this article is to illustrate how cancer registry data can be used to address questions of quality assurance and continuous quality improvement, and to generate contemporary cohorts of patients for retrospective studies. The history and purpose of hospital cancer registries is reviewed and examples of use of registry data provided. Methods: Cancer Registry information, manuals, and definitions were reviewed. The 25-year experience of the lead author in collaborating with registrars and using the cancer registry of a large community hospital in southern California is described. The strengths and weaknesses of such data are discussed. Examples of completed studies are provided to illustrate how such data was organized, analyzed, and presented to physicians and administrators, and for peer reviewed publications. Results: The strengths of such data are the large numbers of patients, validity of date of diagnosis, histologic diagnosis, general stage, and date of death. The major limitations of the data are due to incomplete reporting of specific treatment regimens, especially after the initial 4-month period of management. The quality assurance and quality improvement studies generated proved to be of great interest to local physicians and administrators. Several such studies were used in peer-reviewed publications. The interest and job satisfaction of registrars, and data quality all improved when registry data was being used and reported locally rather than merely being submitted to a national data repository. Conclusion: In the absence of comprehensive integrated medical care data bases, high-quality cancer registries can be used to address local issues related to quality improvement and quality assurance, and provide data for peer-reviewed publications.
Molecular Profile of Breast Cancer in Women at Pointe Noire (Congo Brazzavile)
Authors: CFS Ngatali
Published: January 2024

Objective: To determine molecular profile of breast cancer in Pointe Noire. Patients and Methods: We conducted a cross-sectional study covering the period of January 2018 to September 2019, one (1) year and nine (09) months in the General Hospital of Pointe-Noire. 48 records of patients who were diagnosed with breast cancer with or not immunohistochemistry results at Loandjili General hospital. The variables studied were: Age; the family breast cancer history; tumor localization, histological type, estrogen receptors status, progesterone receptors status; HER2 receptors expression, and molecular profile. The comparison of the qualitative variables was made by the chi2 test and the comparison of the quantitative variables was made by the student test (t-test). The p-values were calculated with the data comparison program that uses chi2 tests (Pearson and Fischer) and t-test. Results were statistically significant for P˂0.05. Results: The average age was 45.7 years with extremes of 22 and 79 years. Two women had a history of breast cancer. Breast cancer was more located in right in 46 % of cases. Ductal invasive carcinoma was the most represented histologic type in 73 %. The histopronostic grade II of Scarff bloom Richardson (SBR) was the most represented in 47.5% of cases. 65% of the estrogen receptors were negative. Negative progesterone receptors were the most represented in 53% of cases. Negative expression of the HER2 were the most represented in 62 % of cases. The molecular profile Luminal A were the le most represented molecular profile accounted for 45. In our study, we noted a prevalence of the age group of 40 to 49 years of 25% of which 15% of Luminal A was also observed. There was not relationship between age and molecur profile (P˃ 0.05). A relationship was noted between molecular profile and histological grade (p ˂0.05). Conclusion: Breast cancer is a real public health problem worldwide. It is the first cancer and the leading cause of cancer death in women worldwide. In Pointe Noire the molecular profile is dominated by Luminal A. This study is important and help to the best therapeutic choice of breast cancer.
A short Review of the ALARA Principle in Radiation Protection
Authors: M Athiyaman
Published: January 2024

Any activity involving radiation should be planned and conducted in such a way that the exposures to individuals are optimally low, taking into consideration the economic and cost aspects. This principle of optimization is called ALARA. ALARA stands for “As Low as Reasonably Achievable”. The ALARA principle states that the radiation exposures should be limited to a minimum level since the Ionizing radiation may produce biological effects in the exposed person. Background of ALARA Concept: The introduction of ALARA was a great philosophical change, as instead of working up to the permissible exposure limits, the idea was to keep exposures to levels as far below the limits as could reasonably be done, considering economic and technical factors. The linear-no-threshold (LNT) model, labeled is the basis of the ALARA protocol; if even small doses lead to slight increases in the risk of cancer than doses should be kept as low as possible. The concept of ALARA was first introduced in 1954 in the National Council on Radiation Protection & Measurements (NCRP) Report, and later in International Commission on Radiological Protection (ICRP) Publication 1 where it was initially called ALAP, the acronym for As Low As Practicable (ICRP 1959b). As per Atomic Energy Regulatory Board (AERB), Govt of India, all radiation work should be carried out in a preplanned and controlled manner so that the exposure to the workers and persons in and near sites of radiation use is kept as low as reasonably achievable (ALARA) and does not exceed the recommended limits. Suitable control measures shall be employed to minimize radiation exposure so that maximum benefits are derived with minimum radiological risk. Discussion: The ALARA principle appears simple but is often misinterpreted and inappropriately applied in radiation protection. It is often interpreted as “as low as possible” without taking into consideration the balancing factors. Considering radiation shielding requirements as an example excessive unnecessary shielding with materials such as lead, steel, or concrete is a waste of global resources. This in turn can cause other damages such as chemical harm and pollution to the environment, which have proven damages to human health. It is more meaningful to make use of the wasted resources for service improvements, such as reducing the charges to patients, investing in better medical technologies, and training of staff. Conclusion: The aims of radiation protection are (i) to avoid the occurrence of deterministic effects and (ii) to limit the risk of stochastic effects. ALARA protocol has successfully limited the exposure of radiation workers to impressively low levels of dose around 1 mSv. Since significant costs are incurred to comply with ALARA and the validity of the LNT model is unclear below doses of 100 mSv, more research on the health effects of low radiation doses is necessary before alternatives to ALARA can become viable.
Stem Cell Dysfunction as a Key Point in Myelodysplastic Syndrome (MDS)
Authors: AR Rahnemoon
Published: January 2024

MDS microenvironment is complemented by non-cell autonomous alterations and autonomous expansion in some malignant clone as well which can state that the conceptualization of pre-leukemia has the complexity at the hematopoietic microenvironment in these patients. Moreover, the pre-leukemic/leukemic stem cell (LSC) model proposes a non-genetic mechanism in leukemic process which harmonized with the genetic model associated with epigenetic deregulation, contribute to leukemia heterogeneity. In addition, LSCs are different from leukemia initiating cells which are only defined by their abilities to initiate leukemia but with or without self-renewal ability. In fact our understanding of the complex pathobiology which now is recognized to arise from acquisition of sequential mutation in HSCs generally with non-genetic alterations that can give the impair normal leukocytes function and/or clonal gain additionally and go too fast to abnormality condition.
Role of Smoking and Alcoholism in Prostate Cancer
Authors: K Dahiya
Published: January 2024

Prostate cancer is one of the commonly diagnosed cancers in men worldwide. This disease is considered to be multifactorial in nature bearing a number of predisposing factors. Smoking and alcoholism are associated with a number of cancers including the prostate cancer. Therefore, this study was conducted on 100 subjects including 50 histopathologically proven patients of prostate cancer and 50 apparently healthy controls. The habit of smoking and alcoholism was enquired about and recorded in all the study participants. The data was analyzed using appropriate statistical methods. It was observed that among patients, 32 patients (64%) were smokers while among controls, 22% (n=11) were smokers. Smoking was found to be associated with the cases of prostate cancer in statistically highly significant manner (p=2.22 X 10-5). Among both the groups, 12% were found to be alcoholic (p=1). All the alcoholics in both the groups were smokers too, therefore, 6 subjects out of 50 (12%) were in the habit of both smoking and alcoholism in both the groups (p=1). Therefore, it may be concluded that smoking has a positive association with prostate cancer.
Association of Body Composition with Static Plantar Foot Pressure in Young Adult
Authors: Singh Amrinder
Published: January 2024

Body composition is a key component of health-related fitness. Dual Energy Absorptiometry (DEXA) is the most reliable technique to evaluate body composition. There is evidence suggesting that obesity is linked to foot disorders leading to & an increase in the risk of falls and injuries. Pedobarography is a fast, simple, non-invasive and reliable method used to measure plantar foot pressure. Studies on the association of body composition using DEXA with the static standing plantar pressure are limited. Purpose: The purpose of the study was to measure the association of fat percentage, Body mass index, type of obesity, fat mass and bone mineral content (BMC) with foot pressure. Methods: 64 young adults participated in this study including 34 females and 30 males with a mean age of 21.7±2.6 years. DEXA and Pedobarography were used for evaluation. Results: It was found that with the increase in every 1% in fat percentage, BMI, android type obesity the forefoot pressure increases by 1.070% (p-value 0.06), 1.079% (p-value 0.07) and 1.106% (p-value 0.25). Gynoid type obesity has an inverse relationship with forefoot pressure. With every 1% decrease in the gynoid type obesity value the forefoot pressure increases by 0.971% (p-value 0.97). Also, 39 out of 64 (60%) subjects with higher fat mass and 34 out of 64 (53%) subjects with greater bone mineral density (BMD) on one side had foot pressure dominance on the same side with p-value >0.05. Conclusion: This study concludes that body composition parameters variably affect the foot pressure in static standing.
A Comparison between Aggression and Self-Esteem among Universiti Teknologi Mara (Uitm) Shah Alam Athletes
Authors: Shaari Jamatul Shahidah
Published: January 2024

Human aggression is a major worldwide health issue that brings negative effects to victims, perpetrators, and society. One of the areas that may be potentially variables for understanding aggression is self-esteem that can influence whether someone will display aggressive behaviour. Therefore, the aim of this study was to determine the relationship between the level of aggression and level of self-esteem among Universiti Teknologi MARA (UiTM) Shah Alam student-athletes. This study is very important to determine the athlete’s aggression and self-esteem level based on the differences of genders and types of sport. Furthermore, the findings of this study may help in promoting a beneficial knowledge among coaches and athletes about aggression level and also self-esteem level toward maintaining and improving sports performance. A correlational study was selected in order to conduct this study. This correlational study was selected because this study was closely related to both descriptive and causal-comparative research. The instrument used for this study comprised of a 10-item Rosenberg SelfEsteem Scale (RSES) and 19-item of Aggression Questionnaire (AQ), which had been distributed in UiTM Shah Alam. The samples consisted of 260 UiTM Shah Alam athletes, included male and female, individual and team sports, age ranged between 18 until 26 years old. Independent t-test showed there was no significant difference between genders and types of sport on aggression level, p > 0.05. Result also showed that there was no significant difference on self-esteem between types of sport, p > 0.05. Meanwhile, a result found that there was a significant difference on self-esteem between genders, p < 0.05. Result also showed that there was a positive correlation between aggression and self-esteem among UiTM Shah Alam athletes, (r = 0.20, p < 0.05). Present findings indicated that athletes who had higher aggression level tend to have a higher level of self-esteem. Therefore, psychological skill training (PST) recommended as a better coping technique in order to promote better adaptation to the constraints of sports involvement.
Short-Term Pregnancy Outcomes Following Monoclonal Antibody Treatment for COVID-19 Infection during the Omicron Surge
Authors: Loza Alexandra
Published: January 2024

Background: Monoclonal antibody (mAb) therapy has been recommended in non-hospitalized COVID-19 positive pregnant individuals with mild to moderate symptoms despite data on safety and efficacy. Objective: To assess short-term outcomes of mAb treatment in COVID-19 positive pregnant patients during the Omicron surge. Methods: This is a descriptive study of pregnant patients receiving mAb therapy from December 1, 2021, and March 18, 2022 during the Omicron surge. Patients received either (1) sotrovimab, or (2) bamlanivimab/etesivimab, or (3) casirivimab/ imdevimab. We reviewed the medical records of pregnant patients who received mAb, gathering baseline demographics and assessing adverse events from mAb infusion. Results: Twenty-one pregnant patients received mAbs during the Omicron surge. The short-term maternal outcomes for most of our cohort were favorable. One patient developed an anaphylactic reaction following infusion of bamlanivimab/etesevimab. One patient required admission to the intermediate care unit for severe COVID-19 fifteen days following infusion, and a second patient developed cardiorespiratory symptoms concerning for post-acute sequelae SARS-CoV-2 infection. Adverse pregnancy outcomes were present in 43.7% of our delivered cohort (n=16). Conclusion: Short-term outcomes in pregnant patients who received monoclonal antibodies for COVID-19 during the Omicron surge are mostly favorable, with symptom resolution and rare adverse events.
An Unusual Complication of Gluteal Fistula after Sacrospinous Ligament Suspension: A Case Report
Authors: Aziz Ali Ayesha
Published: January 2024

Background: Sacrospinous ligament suspension (SSLS), also referred to as sacrospinous ligament fixation, is a well-established transvaginal procedure performed to treat apical prolapse. Serious complications are uncommon following SSLS, and mild infectious complications, such as cystitis, are most common. In this report, we present an uncommon case of gluteal fistula as a complication of this procedure. Case: A multiparous 48-year-old with a history of vaginal hysterectomy with bilateral salpingectomy, anterior and posterior colporrhaphy, and sacrospinous ligament suspension presented one year later with multiple emergency department visits for gluteal abscesses and continuous right gluteal drainage. MRI confirmed a gluteal fistula extending from the sacrum to the right gluteal fold and right piriformis muscle, thought to be caused by retained suture. The patient subsequently underwent an exam under anesthesia in which the reproduction of the vaginal dissection performed to place the SSLS sutures and probing of the fistula failed to expose any suture. The fistula was copiously irrigated with antibiotic solution, and on a 2-week postoperative visit, the fistula was noted to be completely healed. Conclusion: This is a rare case of gluteal fistula as a complication of SSLS procedure. In this case, the suspected retained suture causing the fistula was not identified; however, the fistula was still able to heal
A Prototypical Shift Back to the Original Role of Surgery for Endometriosis in Specialized Centres in Experienced Hands
Authors: Kochar Kaur Kulvinder
Published: January 2024

In the last couple of decades with the modernization of newer instrumentation as well as surgical procedures there has been a rekindled interest in a field of Reproductive Surgery to which obituary had been paid with the advent of assisted reproductive technology (ART) as well as invitro fertilization (IVF). During that time period we were sceptical of Surgery for endometriosis due to surgery performed by incompetent surgeons leading to depletion of ovarian reserve with lowered markers of ovarian reserve for instance- anti mullerian hormone (AMH) as well as antral follicles counts(AFC).Nevertheless worldwide thre is switch towards greater training of reproductive endocrinology &Infertility specialists(REI) personnel in minimally invasive surgical strategies of endometriosis along with need for them to train the coming generations of REI so that with surgery performed by reproductive surgeons shaving expertise in addition to experience the chance of recurrent surgery dwindles & might even avoid need for ART in those desiring fertility. Even if future fertility is not the question REI’s experienced with needling procedures can perform sclerosing therapies which even aid in conception in those who might not have accessibility to a specialized endometriosis centre.
Crosscut and Covey-Tunnel Clusters-Uterine Cervix
Authors: Bajaj Anubha
Published: January 2024

Tunnel clusters of uterine cervix articulate as a subtype of nabothian cyst delineating spherical aggregates of twenty to fifty intensely adherent tubules. Characteristically, lesion demonstrates a complex configuration of endocervical glands with multicystic dilatation. Subcategorized as type A and type B variants, type A tunnel clusters are constituted of miniature, non cystic endocervical glands whereas type B tunnel clusters exemplify cystic dilatation of endocervical glands. Of obscure aetiology, tunnel clusters are posited to represent a sub-involution within foci of endocervical glandular hyperplasia. Tunnel clusters are asymptomatic or may be associated with mucoid vaginal discharge. Type A tunnel clusters are composed of miniature, elongated, non-cystic endocervical glands layered with columnar to low cuboidal epithelium with mucinous cytoplasm, apical vacuoles and basal nuclei. Type B tunnel clusters are comprised of cystically dilated endocervical glands layered with bland, cuboidal or flattened epithelium and permeated with inspissated mucin. Tunnel clusters appear immune reactive to PAX2 wherein type A tunnel clusters with gastric metaplasia appear immune reactive to HIK1083. Tunnel clusters of uterine cervix require segregation from neoplasms such as minimal deviation adenocarcinoma or adenoma malignum, conventional endocervical adenocarcinoma, adenocarcinoma in situ, nabothian cysts and mesonephric remnants or mesonephric hyperplasia of uterine cervix. Tunnel clusters may be appropriately discerned with cogent histological examination of surgical tissue specimens of uterine cervix, appear devoid of precise, applicable therapeutic strategies and do not necessitate alleviation.
Mammary Myofibroblastoma: Report of an Uncommon Case
Authors: Lakhdar Khaoula
Published: January 2024

Mammary myofibroblastoma is an uncommon benign mesenchymatous tumor, representing less than 1% of mammary tumors. First individualized in 1987, it’s a benign tumor of unknown etiology, occurring in equal incidence in post-menopausal women and men. It has with a very large morphological spectrum but its management is surgical and the diagnosis is histological and immune histochemical. We hereby report a case of a myofibroblastoma in a 28-year-old woman that was successfully managed surgically. The particularity of our case is the very young age of our patient, since the cases described in the literature are tumors in post-menopausal women. This case raises the issue of pathology’s polymorphism.
Caesarean Delivery on Maternal Request (CDMR) in a Low Resource Setting
Authors: Walawe Nayaka Sanjaya
Published: January 2024

Rising caesarean delivery rate across the globe is one of the major growing challenges in Obstetrics and Gynecology. Performing a caesarean section without any justifiable medical reason, but only due to maternal request is a huge burden to lot of countries while being an unaddressed problem in developing countries with poor resources. Early interventions to this growing challenge will help to prevent subsequent complications and implications on economy of the developing countries.
Fatel Medicine in Clinical Practice
Authors: Haider Rehan
Published: January 2024

Fetal medicine is a specific field of medicine dedicated to the care and management of the expanding blastula during pregnancy. It contains an off-course range of demonstrative and therapeutic methods proposed to guarantee the health and happiness of two together, the future baby and the expectant parent. This abstract investigates the relevance and meaning of the before-birth cure in contemporary dispassionate practice.In the current age, fetal medicine has supported extraordinary advancements on account of contemporary technologies and a deeper understanding of what happens before birth. Ultrasound imaging, for instance, has enhanced the necessary finish for monitoring before birth, detecting irregularities, and assessing the overall energy of the embryo. Non-obtrusive prenatal experimentation (NIPT) has transformed the early detection of ancestral disorders, permissive prompt interventions, and cognizant accountability for persons. Fetal medicine offers further conditions; it offers a spectrum of healing attacks that can significantly impact gestational consequences. Intrauterine before-birth surgeries, such as curing processes for inborn heart defects or spina bifida, elucidate the field’s volume to mediate and improve the value of history for affected babies. Furthermore, before birth, the cure plays an important role in directing extreme-risk pregnancies. It authorizes close monitoring of motherly and prenatal well-being, ensuring that potential problems are recognized and addressed immediately. This is specifically critical in cases of multiple pregnancies, motherly healing environments, or fetal tumor limits. The field’s significance is further underscored by allure skills to foster early sticking between persons and the unborn adolescent. Seeing the embryo through ultrasound scans and engaging in discussions about allure, fitness, and what’s happening can enhance the heated relationship ‘between expectant parents and their babies. In conclusion, before birth, medicine has enhanced a necessary component of new clinical practice. It offers an inclusive approach to fetal care, including diagnostics, healing interventions, and psychological support for expectant parents. As electronics continue to advance and our understanding of before-birth incidents deepens, before-birth medicine’s part in guaranteeing healthy pregnancies and improving neonatal consequences will certainly stretch to expand and develop.
Web-Based Online Exhibition by Implementing Virtual and Augmented Reality to Visualize Architecture Building Design
Authors: Dinata Ketut Nova Wirya Dinata , Sindu I Gede Partha Sindu , Wahyuni Dessy Seri Wahyuni
Published: January 2024

Web-based online exhibition using immersive technology, namely Virtual Reality & Augmented Reality, has a major effect on the efficiency of time, place, and cost in providing visitors with an understanding of building architecture. Interaction in understanding architectural modeling is also assisted by a technology called Avatar Mediated Communication (AMC) which is the scope of interaction with other visitors in a Virtual Environment created by Virtual Reality technology. Technology that is able to support all website-based reality activities is made with the Laravel & Express Js framework (Website), Spoke Mozilla Hubs (Virtual Reality Environment), and Library AR Js (Augmented Reality Marker Based).  The technology is selected, built, and combined in the stages of the Research & Development (R&D) method, the Multimedia Development Life Cycle (MDLC) model in examining the development stages and user responses to web-based Virtual & Augmented Reality development products. The results of the responses obtained are based on 6 categories in the UEQ (User Experience Questionnaire) instrument. The result showed that the three largest categories that give a positive response are stimulation, attractiveness, and novelty. Meanwhile, the three categories below are efficiency, perspicuity, and dependability. This indicates that the online exhibition in the support of immersive visualization is able to increase user curiosity in trying to enter the virtual reality room presented in web-based Virtual & Augmented Reality.
Proficiency Level and Challenges of Grade 11 Public School Students on Contemporary Issues
Authors: Rios Maria Arvelyn , Bual Joel M. , Madrigal Dennis V.
Published: January 2024

Contemporary issues is essential for K-12 learners to develop their awareness of the social conditions as potential problem solvers. Hence, proficiency assessment is necessary to check their competency acquisition. This study aims to analyze the Grade 10 students’ proficiency and challenges on contemporary issues among public schools in Central Philippines in the importance of studying contemporary issues, political rights, human rights, and educational rights relative to sex and strand. Utilizing a descriptive-comparative approach, a validated and reliability tested questionnaire and checklist were administered to 261 students using beginning, developing, approaching proficiency, proficiency, and advanced responses. In data analysis, mean, standard deviation, frequency count, percentage, rank, Mann Whitney, and Kruskal Wallis were employed. Generally, they have approaching proficiency in all areas indicating that the competencies were not fully acquired. With this, improvement on instruction is critical. Comparatively, there was a difference when grouped to sex and strand where females and TVL students rated higher proficiency than their counterparts. Meanwhile, they are challenged on their motivation to learn, traditional teaching strategies, time management in accomplishing tasks, inadequate learning facilities, and insufficient interactive learning opportunities. Given the results, these imply the importance of improving the teachers’ instructional strategies in ensuring the students’ quality proficiency in Contemporary issues.
Flipped Classroom with Whiteboard Animation to Promote Communication Skill: A Mixed Method Study
Authors: Suwardika Gede , Sopandi Agus Tatang , Indrawan Putu Oktap
Published: January 2024

Communication skills are crucial competencies for both teachers and aspiring educators. However, the reality is that the skills of many teachers are not yet adequate. This research aims to analyze the impact of implementing a Flipped Classroom with Whiteboard Animation on students’ communication skills. The research employed a Convergent Mixed Methods Design, where quantitative and qualitative data were collected concurrently and analyzed separately to confirm their relationship. The participants consisted of 83 students who were elementary school teachers taking the Science Education course. Quantitative data on communication skills were gathered using the ICCS questionnaire, while qualitative data were obtained through observations, completion of student worksheets, and interviews. Quantitative data were analyzed using ANCOVA, while qualitative data underwent qualitative descriptive analysis. The research findings demonstrated that Flipped Classroom with Whiteboard Animation effectively enhanced students’ communication skills through the instructional steps during the webinar. These findings indicate that Flipped Classroom with whiteboard animation can be considered an effective alternative for improving students’ communication skills.
Kinetika Proses Ekstraksi Katalis Bekas Ni/γ–Al2O3 dengan Pelarut Asam Sulfat: Model Shrinking Core dan Model Lump
Authors: Bahri Elsha Pamida , Simanungkalit Ivanna Crecentia Narulita , Susanti Ratna Frida , Gemilar Gelar Panji , Astuti Widi , Petrus Himawan Tri Bayu Murti , Wanta Kevin Cleary
Published: January 2024

Tahapan scale–up dari suatu proses kimia, kinetika atau mekanisme dari proses tersebut perlu untuk dipelajari. Hal ini dilakukan untuk meminimalkan kesalahan dalam tahap perancangan suatu alat proses. Studi kali ini bertujuan untuk mengevaluasi model matematika yang dapat menggambarkan fenomena riil dari proses ekstraksi katalis bekas Ni/γ–Al2O3 dengan menggunakan pelarut asam sulfat (H2SO4). Studi ini melibatkan dua tahapan utama, yaitu tahap pengambilan data eksperimen dan tahap simulasi model matematika terhadap data eksperimen. Data untuk studi kinetika diperoleh melalui eksperimen proses ekstraksi dalam kondisi atmosferis di mana temperatur operasi divariasikan pada 30, 60, dan 85oC. Larutan asam sulfat yang digunakan memiliki konsentrasi 1 M, sedangkan ukuran partikel katalis kurang 74 mikron. Proses ekstraksi dilakukan selama 120 menit dengan pengambilan sampel secara berkala. Kandungan nikel pada sampel tersebut dianalisis dengan menggunakan instrumen Atomic Absorption Spectroscopy (AAS).  Hasil eksperimen menunjukkan bahwa pada temperatur 85oC dan waktu ekstraksi 120 menit, nikel yang diperoleh paling banyak dibandingkan kondisi operasi lainnya, yaitu sebesar 16,95%. Studi kinetika terhadap data eksperimen tersebut menunjukkan bahwa model lump merupakan model kinetika terbaik untuk menggambarkan fenomena fisis yang terjadi selama proses ekstraksi ini berlangsung. Model lump memberikan persentase kesalahan rata–rata yang lebih kecil dibandingkan model shrinking core. Hal ini mengindikasikan bahwa tahapan difusi internal dan reaksi kimia merupakan tahapan yang mengendalikan proses ekstraksi ini.
Somatometri Itik Pengging (Anas platyrhynchos) setelah Pemberian Nanokitosan dalam Pakan
Authors: Nagari Ardelia Padma , Sunarno  , Sitasiwi Agung Janika
Published: January 2024

Nanokitosan adalah jenis polisakarida hasil turunan kitosan yang bersumber dari eksoskeleton arthropoda laut seperti krustasea (udang, lobster, kepiting, teritip, kril) serta kutikula serangga. Nanokitosan telah disetujui sebagai feed aditif oleh Badan Pengawas Makanan dan Obat-obatan Amerika Serikat tetapi masih jarang digunakan oleh para peternak lokal di Indonesia. Berdasarkan potensi tersebut dilakukan penelitian dengan tujuan menganalisis pengaruh kadar pemberian aditif pakan nanokitosan dalam pakan terhadap bobot badan dan somatometri itik pengging yang ditunjukkan dengan panjang badan, lingkar toraks, lingkar abdomen, panjang leher, paruh, sayap, tibia, dan tarsometatarsus. Penelitian ini menggunakan Rancangan Acak Lengkap yang terdiri atas 5 perlakuan meliputi P0 (pakan basal 100%), P0 adalah pakan basal tanpa aditif pakan nanokitosan (100% pakan basal); P1, P2, P3, dan P4 adalah pakan basal yang diberi aditif pakan nanokitosan, masing-masing dengan kadar 2,5; 5; 7,5; dan 10 g/kg pakan, tiap perlakuan diulang sebanyak lima kali. Pakan dan minum diberikan secara ad libitum. Data dianalisis menggunakan uji Kruskal Wallis. Berdasarkan hasil analisis penelitian disimpulkan bahwa nanokitosan sebagai aditif pakan dapat mempertahankan bobot badan dan ukuran somatometri pada itik pengging berdasarkan indikator yang diukur, meliputi panjang badan, lingkar toraks dan abdomen, panjang sayap, leher, paruh, tibia, dan tarsometatarsus. Penggunaan nanokitosan sebagai aditif pakan dapat diberikan pada itik pengging (Anas platyrhynchos) umur 4 minggu (fase starter) agar dapat diperoleh efek yang optimal terhadap proses pencernaan, metabolisme, dan performa produktivitas yang terkait dengan bobot badan dan ukuran somatometri pada itik pengging.
Life Cycle Assessment a Coal Mining in East Kalimantan
Authors: Diharjo Deniela Flora Mariyne Wongso , Manik Yosef Barita Sar
Published: January 2024

A Life Cycle Assessment study aimed at identifying the environmental impacts of a coal mining process has been carried out. The scope of the process includes land clearing to coal barging (cradle to gate). The functional unit used is the production of 1 ton of coal. The inventory data in this research is site specific, collected from a mining company located in East Kalimantan during the period September 2022 to June 2023. Impact analysis was characterized using the ReCiPe 2016 midpoint (H) method with the help of OpenLCA v.2.0.2 software. From the impact analysis, it was found that the coal mining operations studied have the potential to produce Fine Particulate Matter Formation (0.122 kg PM2.5eq), Global Warming (73.28 kg CO2eq), Terrestrial Acidification (0.4114 kg SO2eq), Ozone formation-human health and Ozone formation-terrestrial ecosystems (0.54 kg NOx eq), Land Use (4.42×10-4 m2a crop eq), and Water consumption (11.44 m3). The potential for Particulate Matter Formation and Global Warming is generally related to the process of moving materials and water consumption caused by the process of transporting coal. From this research, it was found that the overburden stripping process is an environmental hotspot for the coal mining process because it has the greatest potential impact of all existing processes.
Topic Modelling Latent Dirichlet Allocation untuk Klasifikasi Komentar pada Layanan Streaming Platform
Authors: Royani Noorhanida , Widodo Catur Edi , Warsito Budi
Published: January 2024

Seiring dengan berkembangnya teknologi, memunculkan banyak platform online untuk streaming film. Streaming platform banyak digunakan masyarakat seperti netflix, disney+, hbo go, we tv, vidio. Banyaknya perbandingan antar streaming platform menjadi perbincangan dimedia sosial yaitu twitter. Opini yang disampaikan pengguna streaming platform berisi komentar positif dan komentar negatif yang mempengaruhi pengguna lainnya yang ingin menonton film. Penelitian ini dilakukan untuk mengkaji perbandingan antara komentar positif dan komentar negatif pengguna streaming platform pada media sosial Twitter. Metode Latent dirichlet allocation dapat digunakan sebagai topic modelling dan Support Vector Machine untuk klasifikasi. Pada tahapan pengambilan data dengan menggunakan tools framework scrapy dengan python, data diambil sebanyak 5.000 dan dilakukan preprocessing text. Metode LDA dapat mempresentasikan topik dan dokumen serta klasifikasi menggunakan Support Vector Machine (SVM) mendapatkan hasil komentar positif lebih banyak dari pada komentar negatif. Hasil evaluasi preforma didapatkan nilai akurasi 0,88, recall 0,88, F1score 0,87, precision 0,88. Topic Modelling Latent Dirichlet Allocation (LDA) untuk Klasifikasi Komentar pada Layanan Streaming Platform dengan menggunakan 5,000 data diambil dari sosial media yaitu twitter yang terbagi menjadi komentar positif dan komentar negatif. Hasil ini dipengaruhi dari jumlah komentar positif yang lebih dominan dari pada komentar negatif. Implikasi dari penelitian ini adalah pentingnya memperhatikan keseimbangan data dalam melakukan klasifikasi komentar pada platform streaming agar hasil prediksi klasifikasi dapat lebih akurat.
The Problems in Implementing the Function of the Integrated Law Enforcement Center (Gakkumdu) as an Election Law Enforcement Institution
Authors: Faizal Liky
Published: January 2024

The Integrated Law Enforcement Center, hereinafter referred to as Gakkumdu, is the center of law enforcement activities for election crimes consisting of elements. The purpose of establishing Gakkumdu is to encourage the election judicial process to take place quickly and accurately. This research aims to analyze the implementation of the Sentra Gakkumdu function in Lampung Province and the inhibiting factors in the implementation of the Sentra Gakkumdu function in election law enforcement in Lampung Province. The results showed that the implementation of the function of the Sentra Gakkumdu in law enforcement of election criminal offenses by the Sentra Gakkumdu in the elections in Lampung Province was ineffective. This can be seen from the many cases handled; not all of them have been followed up on by the Gakkumdu center. The main problem in implementing the law enforcement function of election crimes by the Gakkumdu center is that there are often differences in legal perceptions among Gakkumdu members in determining whether a violation meets the elements of an election violation.
DETERMINANTS OF PARENTAL SCHOOL CHOICE: A SYSTEMATIC REVIEW OF THE LITERATURE
Authors: Bekele Mekete Shiferaw , Kenea Ambissa
Published: January 2024

The study examined determinants of parental school choice internationally aiming to identify research gaps and providing suggestions for researchers. Articles published between 2000 and 2023 were searched from 9 databases and a total of 30 articles were included in the review. The result showed that parental school choice is critically affected by parent-related factors like parents’ education, income, family size, and education level of the children, and the school-related factors: quality of education, performance of teachers, school facilities, school cost, parent-teacher relationship, and school curriculums are the major ones. The safety/security related and children’s educational achievement is found slightly affecting factor on parental school choice. The research design of reviewed articles is found descriptive research although the explanatory research design was appropriate as it supports better. The study also identified factors for developing and developed countries are different. For developing countries socio-economy, income, family education, cost, curriculum, technology,  proximity to home, number of children, and age of the child are the major ones. For developed countries: school quality, teacher performance, special programs, playground, training teachers, library service, student moral development, school performance, environment, school ranking, interaction with parents, discipline, curriculum structure, knowledge, result, and communication skills are paid attention for parental school choice decisions.
Implementasi Kebijakan Perlindungan Anak Dalam Peraturan Desa Nomor 4 Tahun 2018 di Desa Panduman Kecamatan Jelbuk Kabupaten Jember
Authors: Noer Sunan Moch. Ilham , Ulfa Meilina , Arif Arif , Ady Mahardika Debby Andrean , Zuhudia Primahesti Gitri
Published: January 2024

Implementasi Peraturan Desa Nomor 4 Tahun 2018 Tentang Perlindungan Anak merupakan salah satu ketetapan perintah Desa Panduman sebagai upaya dalam mencegah, menekan, dan mengatasi fenomena pelanggaran anak yang terjadi di Desa Panduman seperti banyaknya anak yang putus sekolah, pernikahan dini, kekerasan terhadap anak, pekerja anak, dan juga stunting. Penelitian ini menggunakan metode penelitian kualitatif deskriptif. Adapun ketiga program tersebut diantaranya ialah Program Sanggar Merdeka, Program Forum Anak, dan Program Rumah Desa Sehat. Selanjutnya, adapun dalam pengumpulan data penelitian di lapangan peneliti menggunakan tiga teknik kualitatif yakni observasi secara langsung, wawancara semi tertsruktur, dan juga studi dokumentasi. Fokus pada ranah analisis dalam mengkaji implementasi peraturan desa, disini peneliti penggunakan teori model implementasi menurut Van Matter and Van Horn(2016) mengemukakan bahwasanya dalam menganalisis sebuah implementasi kebijakan peraturan desa dapat dilihat melalui enam indikator yakni ukuran dan tujuan kebijakan, sumber daya yang terlibat, para pelaksana kebijakan, responsifitas para pelaksana dan masyarakat, pola komunikasi, kondisi lingkungan sosial, ekonomi, dan juga politik. Secara garis besar, analisa kebijakan yang dilakukan melalui ketiga program menggambarkan bahwasanya ketiga program mampu memenuhi beberapa indikator capaain keberhasilan kebijakan sehingga dapat memberikan perubahan peningkatan kesejahteraan anak terutama dalam ranah pemenuhan hak dan kebutuhan mereka.