bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical extraction of a cannula tip embedded in the neck after liposuction at an external facility: a case report
Authors: Mun Hye Gwang , Kim Yu Jin
Published: February 2025

Liposuction is a widely performed aesthetic plastic surgery procedure used for various purposes. The use of advanced liposuction techniques has reduced the risk of complications. Nevertheless, they can still occur unexpectedly. Herein, we report a rare case of a 44-year-old patient who experienced a broken cannula tip lodged in her neck during cervicofacial liposuction. This case highlights the need for vigilance in preventing such complications through rigorous preoperative equipment inspections and proper instrument maintenance. Additionally, when attempting to remove a broken instrument tip, it is crucial to perform imaging examinations both before and during the procedure to precisely locate and extract the fragments, ensuring patient safety and a successful outcome.
Coexistence of neuroendocrine carcinoma and squamous cell carcinoma of the skin after kidney transplantation: a case report
Authors: Yoon Woohyuk , Lee Jong Im , Lee Joon Ho
Published: February 2025

Neuroendocrine carcinoma (NEC) is a rare aggressive tumor of the skin with a shared phenotype of both endocrine and neuronal features. Its behavior includes rapid progression, common local recurrence, frequent metastasis to local lymph nodes, and occasional systematic involvement. The risk factors for NEC are similar to those for other skin cancers and mainly include ultraviolet light exposure, older age, T-cell immunosuppression, fair skin, and male sex. NEC is seen more frequently in the immunosuppressed population, and we report a rare case of NEC combined with squamous cell carcinoma (SCC) in a patient who underwent kidney transplantation. A 66-year-old man was referred with a brownish plaque on left cheek, and a punch biopsy result indicated SCC in situ. Wide excision was performed, and the defect was reconstructed using a bilobed flap. The final biopsy confirmed SCC combined with carcinoma with neuroendocrine differentiation, and positron emission tomography-computed tomography confirmed the absence of lymph node metastasis or systemic involvement. The patient showed no evidence of recurrence or other postoperative complications.
Fungal cortices in kauri resin from New Zealand as taphonomic and ecological analogues of Cretaceous amber cortices: an actualistic approach
Authors: Peñalver Enrique , Speranza Mariela , Delclòs Xavier
Published: February 2025

Several papers have been published in the last two decades about the peculiar cortices that commonly are present in Cretaceous amber pieces from diverse terrestrial western Tethyan localities. These cortices are constituted by networks of filamentous structures, and have been identified as mycelia composed of hyphae of resinicolous fungi according to a multidisciplinary research of Albian Spanish samples using diverse techniques. Main evidence indicating its fungal nature was the taphonomic scenario inferred and the detection of preserved chitin polysaccharides in the filamentous structures, using specific chitin markers visualized under confocal laser microscopy. Herein is present a similar fungal colonization pattern forming thin cortices observed in extant kauri pine resin (Agathis australis: Araucariaceae) from New Zealand. It has been compared with the typical pattern previously observed in the Spanish Cretaceous amber cortices. The similar fungal cortices in Agathis resins are considered as taphonomic and ecological analogues, but no phylogenetic relationship is suggested. The palaeoecological implications, with regard to Spanish Cretaceous forest environmental conditions that this extant correlate suggests, are discussed; also a new unusual growth of resinicolous fungus with the same microscopic hyphae features in Cretaceous amber are presented. Conclusions can be extended to Cretaceous amber cortices from other Laurasian localities.
Evidências de efetividade da psicoterapia psicanalítica para o TDAH: Uma revisão integrativa
Authors: Deon Elenice , Ibias Flach Vitória , Röhnelt Ramires Vera Regina
Published: February 2025

As psicoterapias psicanalíticas para tratamento do TDAH têm sido pouco valorizadas, com preferência dada à medicação e às terapias cognitivo-comportamentais. Portanto, este estudo objetivou investigar se existem evidências de efetividade da psicoterapia psicanalítica ou psicodinâmica para o tratamento de crianças e adolescentes com TDAH. Realizou-se uma revisão narrativa da literatura. As bases de dados consultadas foram Scopus, Pubmed e Biblioteca Virtual em Saúde (BVS), selecionando-se estudos publicados nos últimos dez anos. Com base nos descritores, foram recuperados 68 artigos. Após leitura dos resumos e aplicação dos critérios de inclusão e exclusão, foram selecionados nove artigos. Dos nove artigos, seis foram  estudos de caso e três estudos quantitativos naturalísticos ou controlados. Dos estudos selecionados, apenas um não apontou resultados positivos para o tratamento psicanalítico do TDAH, tendo utilizado uma intervenção de psicoterapia psicanalítica de curto prazo. Com base nos estudos encontrados, pode-se afirmar que existem algumas evidências de efetividade da psicoterapia psicanalítica para o tratamento do TDAH em população jovem. Ao explorar os aspectos psicodinâmicos do indivíduo, oferece uma alternativa complementar à medicação e às terapias cognitivo-comportamentais, permitindo uma visão mais ampla e integrada do sujeito, para além do quadro sintomático, e promovendo mudanças estruturais que beneficiam a vida dos pacientes.
SOCIOLOŠKI POGLEDI NA DRUŠTVENU DEZORGANIZACIJU I SPORTSKO HULIGANSTVO
Authors: Ćorluka Bojan
Published: February 2025

Rad će se bazirati na komparativnom objašnjenju društvene dezorganizacije i sportskog huliganstva iz ugla sociološke nauke. Sama problematika rada upućena je na objašnjenje sportskog huliganstva kao agresivnog ponašanja. Da bi se održao stabilan društveni poredak, potreban je normativni i vrednosni konsenzus, kao i efikasni institucionalni mehanizmi društvene kontrole. Svaki sistem ima logiku svoga razvoja, ona se zasniva na određenom načinu proizvodnje koji reprodukuje sve druge vidove djelatnosti kao što su: ideologija, politika, kultura, način i stil života, sport. Svaki sportski hazard uključuje ne samo neočekivanost i iznenađenje kada je u pitanju krajnji rezultat, već i rizik koji zadovoljava potrebe publike za jakim uzbuđenjima, u kojima se ličnost prazni i oslobađa agresivnosti. Ova pojava može da vodi ka nasilju, tj. u situaciju kada se nemogućnost postignuća racionalnog opravdava iracionalnim. Društvena dezorganizacija dovodi do prekida ravnoteže, kao i gubitka socijalne kontrole, koja je praćena raspadom formalnih i neformalnih obrazaca društvenih odnosa što prouzrokuje nesposobnost efikasnog djelovanja u skladu sa postavljenim ciljevima. U radu se zastupa stav da je u širenju sportskog huliganstva primaran socijalni kontekst, a ne biološke i psihološke dispozicije.
ОСВРТ НА ПРЕСУДУ ЕВРОПСКОГ СУДА ПРАВДЕ У СЛУЧАЈУ КОМПАНИЈЕ ЕВРОПСКЕ СУПЕРЛИГЕ ПРОТИВ UEFA И FIFA
Authors: Беловић Јелена
Published: February 2025

Нема сумње да је пресуда Европског суда правде (ECJ) од 21. децембра 2023. од великог значаја за свет фудбала. Могло би се оквалификовати као прави „цунами“ у европском клупском такмичењу. То је изазвало реакције целог фудбалског друштва укључујући све његове релевантне субјекте: националне савезе, конфедерације, играче, навијаче и друге заинтересоване стране. Наиме, ECJ одлучује да су одлуке врховног органа Међународне фудбалске федерације (FIFA) и Уније европских фудбалских асоцијација (UEFA) донете у циљу забране формирања Европске Супер лиге (ESL) незаконите. Одлуке FIFA и UEFA засноване су на правилима о претходном одобравању међународних фудбалских такмичења и санкцијама против професионалних клубова који намеравају да створе одвојена удружења и такмичења осим оних које су креирале и дозвољавале FIFA и UEFA. ESL одлучује да такво понашање представља злоупотребу доминантног положаја забрањену чланом 102. Уговора о функционисању Европске уније (TFEU), као и чланом 101. TFEU-а који се односи на правила о конкуренцији. Поред тога, пресуда Европског суда правде се бави другим важним питањима као што су слободно кретање људи, услуга и капитала.
EFKTI PROPRIOCEPTIVNOG TRENINGA NA BRZINU USVAJANJA GIMNASTIČKIH ELEMENATA KOD DJECE OSNOVNOŠKOLSKOG UZRASTA
Authors: Prodić Dimitrije , Bijelić Snežana , Jovanović Saša , Fulurija Dalibor
Published: February 2025

Istraživanje je proučavalo uticaj eksperimentalnog proprioceptivnog treninga na brzinu usvajanja odabranih gimnastičkih elemenata na gredi kod učenika osnovne škole. Rezultati su pokazali da je eksperimentalni tretman imao pozitivan učinak na brže savladavanje tehničkih elemenata gimnastičkog višeboja na gredi. T-test i Wilcoksonov test su potvrdili statistički značajnu razliku između eksperimentalne i kontrolne grupe na nivou značajnosti od 0,01. Eksperimentalni tretman je imao statistički značajan uticaj na brzinu usvajanja gimnastičkih elemenata izvedenih u dinamičkoj ravnoteži, poput različitih vrsta okreta. S druge strane, nije ostvario statistički značajan uticaj na brzinu usvajanja statičkih elemenata poput prednje vage i visokog prednoženja, koji su se pokazali jednostavnijima za savladavanje. Istraživanje zaključuje da se ovako konstruiran eksperimentalni proprioceptivni trening može ponuditi kao efikasno trenažno sredstvo u radu s djecom osnovnoškolskog uzrasta, te da će ostvariti pozitivne uticaje na brzinu usvajanja gimnastičkih elemenata i motoričku sposobnost ravnoteže. Preporučuje se i duži period primjene tretmana za postizanje još snažnijeg uticaja.
THE ROLE OF CLUB MANAGEMENT IN ORGANIZING, EDUCATING, AND SELECTING SUPPLEMENTS AND ADEQUATE NUTRITION FOR SWIMMERS
Authors: Gavrilović Ana , Selaković Stefan , Gajević Aco , Perović Aleksandra
Published: February 2025

Organizing the nutrition of athletes represents a crucial factor for their professional advancement and is a key part of everyday life without which success is impossible. Sports clubs pay special attention to organizing proper supplementation and nutrition. In recreational sports, it is often said that nutrition accounts for 70% of the impact, while exercise accounts for 30% of athletes' physical fitness. Without adequate nutrition, it is impossible for the body to endure the efforts both in training and in sports competitions. The recovery of athletes after strenuous exercise is conditioned by quality nutrition and proper supplementation. This paper was created for the needs of the management of Belgrade swimming clubs by reviewing the latest global research in the field of sports nutrition and supplementation, by students and professors of the Faculty of Sport
RELATIONS BETWEEN THE PERSONALITY TRAITS OF THE FIVEFACTOR MODEL AND MOTIVATION OF JUNIOR VOLLEYBALL
Authors: Ivanović Miroljub
Published: February 2025

The aim of this transversal research was twofold: to check the metric characteristics of the measuring instruments, and to examine the interactions of the model of The Big Five personality traits – Big Five (as predictor) and dimensions of motivation (as criterion) on a sample of junior volleyball players. The pertinent sample included (N = 218) junior Serbian volleyball players of average age (Mage= 18.05, SD = 1.52). the following measuring instruments were used: Big Five Inventory (BFI), Sport Attitudes Inventory (SAI), and Task and ego orientation in Sport Questionnaire (TEOSQ). Cronbach's alpha reliability coefficient has shown that the values of internal consistency of the measuring instruments are satisfactory, which means that they are suitable to be used in the context of Serbian sports. Two canonical functions statistically significant on the level (p ≤ 0.03) were extracted using the canonical correlation analysis. The first pair of the isolated canonical factors, with 37% of the explained variance, is determined by personality traits: conscientiousness, extraversion, and openness, as well as by the dimensions of motivation: motive for achieving power, motive for achieving success, and task orientation. The second pair of the isolated canonical factors in the group of personality traits is defined by the variables: neuroticism, agreeableness, and conscientiousness (on the negative end), motive for avoiding failure, and goal orientation (on the positive end). That isolated canonical latent variable indicates that young athletes are prone to avoidance as a model of behavior. Empirical findings of this research can be used in player selection and managing sports training and competition of junior volleyball players. The obtained canonical structures can contribute to a better understanding of correlations between latent variables in adolescent volleyball population in Serbia, which have not been sufficiently examined nor scientifically explained.
EFFECTS OF FITNESS PROGRAMS ON FUNCTIONAL CAPABILITIES
Authors: Radojičić Nebojša , Stanić Đorđe
Published: February 2025

Group fitness programs are organized trainings that are conducted in a group environment under the guidance of an instructor, and are designed to cover different levels of physical fitness. The research included 52 respondents, divided into experimental and control groups. Bruce's treadmill test with seven output variables was used to assess functional abilities. The experimental program lasted 12 weeks with a combination of different programs and intensity between 40-85%. The results indicate positive effects of group fitness programs on cardiac work, speed improvement, effects on absolute and relative oxygen consumption. No differences were recorded in the forced vital capacity variable suggesting the need for additional research to optimize the effects on all aspects of physical fitness. It is recommended that future research include larger samples and longer time periods to further examine effects on functional abilities.
THE EFFECTS OF PROPRIOCEPTIVE TRAINING ON THE SPEED OF ASSUMPTION OF GYMNASTIC ELEMENTS IN CHILDREN OF PRIMARY SCHOOL AGE
Authors: Prodić Dimitrije , Bijelić Snežana , Jovanović Saša , Fulurija Dalibor
Published: February 2025

The research studied the influence of experimental proprioceptive training on the speed of acquisition of selected gymnastic elements on beam in elementary school students. The results showed that the experimental treatment had a positive effect on the faster mastering of the technical elements of the gymnastic all-around on the beam. The t-test and Wilcoxon test confirmed a statistically significant difference between the experimental and control groups at a significance level of 0.01. The experimental treatment had a statistically significant effect on the speed of acquisition of gymnastic elements performed in dynamic balance, such as different types of turns. On the other hand, it did not have a statistically significant effect on the speed of adoption of static elements such as front balance and high forefoot, which proved to be easier to master. The research concludes that the experimental proprioceptive training constructed in this way can be offered as an effective training tool in working with children of elementary school age, and that it will have positive effects on the speed of acquisition of gymnastic elements and the motor ability of balance. A longer period of application of the treatment is recommended to achieve an even stronger effect.
Effects of abiotic and biotic stresses on antagonistic activities of symbiotic bacterial strains isolated from Adenosma bracteosum
Authors: Nguyen Thanh-Dung , Duong Huu-Nghia , Nguyen Phu-Tho , Pham Thuy-Trang , Nguyen Huu-Hiep , Nguyen Thi-Pha , Nguyen Huu-Thanh
Published: February 2025

Adenosma bracteosum Bonati has been widely used in traditional and modern Vietnamese medicine for treating hepatitis and lung diseases. Endophytic bacteria, which reside within the cells of medicinal plants, play a vital role in enhancing host plant growth and survival through the production of unique secondary metabolites. These metabolites are significant for both fundamental and applied research, particularly in sustainable agriculture. This study identified the Bacillus velezensis strain SB1R13.2, isolated from A. bracteosum, as a producer of extracellular antibacterial compounds when exposed to pathogenic bacteria. However, abiotic factors such as culture medium composition, pH, and temperature did not induce similar production in this strain.

Gas chromatography-mass spectrometry analysis of the cell-free extract identified at least eight compounds, including putative antibacterial agents. These findings highlight the potential of strain SB1R13.2 as a promising antibacterial agent, offering resistance against diverse pathogens. These results highlight the potential of B. velezensis SB1R13.2 as a valuable source of antibacterial compounds, with potential applications in combating a broad range of pathogenic bacteria and advancing both medical therapies and sustainable agricultural practices.
The Influence of Risk Aversion on Brand Loyalty with Brand Trust and Brand Affect as Mediating Variables
Authors:   Universitas Ciputra Surabaya, Wicaksono Nurfuad
Published: February 2025

Currently cosmetic products are no longer only intended for women, but also for men. Thus, creating opportunities and a conducive environment for the emergence of new companies. With the increasing number of companies in the men's cosmetic industry today, how to build brand loyalty is one of the biggest challenges companies will face. This study aims to explore the relationship between risk aversion and brand loyalty, and test whether this relationship is mediated by brand trust and brand affect on the purchase of cosmetic and body care products by men. The selection of the sample was carried out using a purposive sampling method with 130 respondents whose criteria were male students at Ciputra University Surabaya. Data analysis used the SEM-PLS variant-based structural equation method with the SmartPLS 4 program. The results showed that risk aversion was statistically significant in influencing brand trust, brand affect, and brand loyalty. Brand trust and brand affect are also statistically significant in influencing brand loyalty. By analyzing brand loyalty and the variables that influence it, cosmetic and men's body care product companies can understand how to develop brand loyalty, especially by paying attention to the aspects of risk aversion, brand trust, brand affect, and brand loyalty.
Enhancement of optomicrowave and optomagnonic entanglements in a optomagnomechanical system with coherent feedback
Authors: SHI Jiajia  , LIU Xiaomin  , ZHANG Chong  , XU Minghui  , LIANG Yunyun  , ZHANG Jing  ,   1 College of Physics and Electronic Engineering, Shanxi University, Taiyuan 030006, China;,   2 State Key Laboratory of Quantum Optics Technologies and Devices, Shanxi University, Taiyuan 030006, China
Published: February 2025

Optomicrowave entanglement and optomagnonic entanglement have significant applications in constructing hybrid quantum network and optical controlling magnons. In this paper, a theoretical scheme of enhancing optomicrowave and optomagnonic entanglements is proposed, based on a coherent-feedback-assisted optomagnomechanical (OMM) system. By inserting a thin membrane between the input-output mirror and the high-reflective-mirror-attached YIG bridge, the system consists of four kinds of modes: optical mode, microwave mode, mechanical mode, and magnon mode. In this system, optical and microwave modes interact with each other through the mechanical mode, while the magnon mode couples with the microwave mode through magnetic-dipole interaction. The entanglement is originally generated between optical and phonon modes under the two-mode squeezing mechanism (blue-detuned driven), then the generated entanglement is transferred to the optical and microwave modes through the state transfer mechanism (red-detuned driven) between the microwave and phonon modes and is further transferred to the optical and magnon modes by the magnetic-dipole interaction between the microwave and magnon modes. Adopting the negative logarithm criterion, the variations of the optomicrowave and optomagnonic entanglements with different detunings, coupling strengths, and decay rates are thoroughly investigated. Furthermore, the optimal coherent feedback parameters and the physical mechanisms of generating and transferring entanglement are analyzed, and the entanglement enhancements by adding the feedback loop are discussed. The results show that after adding coherent feedback, optomicrowave and optomagnonic entanglements can be enhanced effectively within a wide range of parameters and the enhancement can also be well maintained. Our findings provide a theoretical basis for connecting different nodes (different physical systems) to construct hybrid quantum networks, flexibly controlling the quantum properties of magnons, and preparing macroscopic quantum states.
Trial-by-trial inter-areal interactions in visual cortex in the presence or absence of visual stimulation
Authors: Hidalgo Dianna , Dellaferrera Giorgia , Xiao Will , Papadopouli Maria , Smirnakis Stelios , Kreiman Gabriel
Published: February 2025

State-of-the-art computational models of vision largely focus on fitting trial-averaged spike counts to visual stimuli using overparameterized neural networks. However, a computational model of the visual cortex should predict the dynamic responses of neurons in single trials across different experimental conditions. In this study, we investigated trial-by-trial inter-areal interactions in the visual cortex by predicting neuronal activity in one area based on activity in another, distinguishing between stimulus-driven and non-stimulus-driven shared variability. We analyzed two datasets: calcium imaging from mouse V1 layers 2/3 and 4, and extracellular neurophysiological recordings from macaque V1 and V4. Our results show that neuronal activity can be predicted bidirectionally between L2/3 and L4 in mice, and between V1 and V4 in macaques, with the latter interaction exhibiting directional asymmetry. The predictability of neuronal responses varied with the type of visual stimulus, yet responses could also be predicted in the absence of visual stimulation. In mice, we observed a bimodal distribution of neurons, with some neurons primarily driven by visual inputs and others showing predictable activity during spontaneous activity despite lacking consistent visually evoked responses. Predictability also depended on intrinsic neuronal properties, receptive field overlap, and the relative timing of activity across areas. Our findings highlight the presence of both stimulus- and non-stimulus-related components in interactions between visual areas across diverse contexts and underscore the importance of non-visual shared variability between visual regions in both mice and macaques.
Distinct representational properties of cues and contexts shape fear learning and extinction
Authors: Bouyeure Antoine , Pacheco Daniel , Fellner Marie-Christin , Jacob George , Kobelt Malte , Rose Jonas , Axmacher Nikolai
Published: February 2025

Extinction learning does not erase previously established memories but inhibits the expression of fear by the formation of new memory traces that are strongly context-dependent. Previous human neuroimaging studies using representational similarity analysis revealed several core properties of memory traces during fear learning, including their tendency to generalize beyond the initial context – a process described as “cue generalization” – and their reliance on sensory rather than conceptual representational formats. How fear memories are altered during extinction learning, however, remains largely unknown. To address this question, we used a novel experimental paradigm involving multiple cues and contexts in each experimental phase, which allowed us to disentangle the effect of contingency changes (i.e., reversal learning) from the disappearance of unconditioned stimuli during extinction learning. Our data show that contingency changes during reversal induce memory traces with distinct representational geometries characterized by stable activity patterns across repetitions in the precuneus, which interact with specific context representations in medial and lateral prefrontal cortex. The representational geometries of these traces differ strikingly from the generalized patterns established during initial fear learning and persist in the absence of an unconditioned stimulus during extinction. Interestingly, increased levels of prefrontal context specificity predict the subsequent reinstatement of fear memory traces, providing a possible mechanistic explanation for the clinical phenomenon of fear renewal. Our findings show that contingency changes induce novel memory traces with distinct representational properties that are reminiscent to those observed during episodic memory formation and contrast with the generalized representations of initial fear memories. These results shed new light on the neural mechanisms underlying the malleability of memories that support cognitive flexibility, and contribute to conceptual frameworks of extinction learning during the treatment of anxiety disorders.
Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition
Authors: Wang Liyi , Liu Shiqi , Zhang Shu , Wang Yizhen , Zhou Yanbing , Shan Tizhong
Published: February 2025

Conjugated linoleic acids (CLAs) can serve as a nutritional intervention to regulate quality, function and fat infiltration in skeletal muscles but the specific cytological mechanisms are still unknown. Here, we applied single-nucleus RNA-sequencing (snRNA-seq) to characterize the cytological mechanism of CLAs regulates fat infiltration in skeletal muscles based on pig models. We investigated the regulatory effects of CLAs on cell populations and molecular characteristics in pig muscles and found CLAs could promote the transformation of fast glycolytic myofibers into slow oxidative myofibers. We also observed three subpopulations including SCD
+
/DGAT2
+
, FABP5
+
/SIAH1
+
, and PDE4D
+
/PDE7B
+
subclusters in adipocytes and CLAs could increase the percentage of SCD
+
/DGAT2
+
adipocytes. RNA velocity analysis showed FABP5
+
/SIAH1
+
and PDE4D
+
/PDE7B
+
adipocytes could differentiate into SCD
+
/DGAT2
+
adipocytes. We further verified the differentiated trajectory of mature adipocytes and identified PDE4D
+
/PDE7B
+
adipocytes could differentiate into SCD
+
/DGAT2
+
and FABP5
+
/SIAH1
+
adipocytes by using high IMF content Laiwu pig models. The cell-cell communication analysis identified the interaction network between adipocytes and other subclusters such as fibro/adipogenic progenitors (FAPs). Pseudotemporal trajectory analysis and RNA velocity analysis also showed FAPs could differentiate into PDE4D
+
/PDE7B
+
preadipocytes and we discovered the differentiated trajectory of preadipocytes into mature adipocytes. Besides, we found CLAs could promote FAPs differentiate into SCD
+
/DGAT2
+
adipocytes via inhibiting c-Jun N-terminal kinase (JNK) signalling pathway
in vitro
. This study provides a foundation for regulating fat infiltration in skeletal muscles by using nutritional strategies and provides potential opportunities to serve pig as an animal model to study human fat infiltrated diseases.
Enhancing market trend prediction using convolutional neural networks on Japanese candlestick patterns
Authors: Mersal Edrees Ramadan , Karaoğlan Kürşat Mustafa , Kutucu Hakan
Published: February 2025

This study discusses using Japanese candlestick (JC) patterns to predict future price movements in financial markets. The history of candlestick trading dates back to the 17th century and involves the analysis of patterns formed during JC trading. Candlestick patterns are practical tools for the technical analysis of traders in financial markets. They may serve as indicators of traders’ documents of a potential change in market sentiment and trend direction. This study aimed to predict the following candle-trend-based JC charts using convolutional neural networks (CNNs). In order to enhance the accuracy of predicting the directional movement of subsequent financial candlesticks, a rich dataset has been constructed by following a structured three-step process, and a CNN model has been trained. Initially, the dataset was analyzed, and sub-charts were generated using a sliding window technique. Subsequently, the Ta-lib library was used to identify whether predefined patterns were present within the windows. The third phase involved the classification of each window’s directional tendency, which was substantiated by employing various technical indicators to validate the direction of the trend. Following the data preparation and analysis phases, a CNN model was developed to extract features from sub-charts and facilitate precise predictions effectively. The experimental results of this approach demonstrated a remarkable predictive accuracy of up to 99.3%. Implementing cross-validation techniques is essential to verify the reliability and overall performance of the model. To achieve this goal, the dataset was divided into several small subsets. Subsequently, the model was trained and evaluated multiple times using different combinations of these subsets. This method allows for a more accurate assessment of the model’s predictive capabilities by examining its performance on unseen data.
Association between psychosocial stressors and temporomandibular disorders in clinical dental students: a cross-sectional study
Authors: Alqarni Abdullah , Hosmani Jagadish , Alassiri Saeed , A. Alqahtani Ali Mosfer , Alfaifi Ali , Al Jazea Shuayl Abdulaziz
Published: February 2025

Background

Temporomandibular disorders (TMDs) comprise an extensive spectrum of conditions that originate from diverse complex components of the temporomandibular joint. It is generally acknowledged that the biopsychosocial model is the preeminent framework for understanding the aetiology of TMDs. Anxiety, depression, and tension are among the psychological disorders that are commonly observed in dental students. The current research probed the propinquity of psychosocial stressors and TMD-like symptoms among clinical dental undergraduates residing in the Aseer region of Saudi Arabia, with a specific emphasis on the functional implications for their overall well-being.

Methods

This research included 89 clinical dentistry students who completed online questionnaires. The Patient-Reported Outcomes Measurement Information System (PROMIS) and Oral Health Impact Profile for Temporomandibular Disorders (OHIP-TMD) were used in these surveys. The trait-related attributes of TMD impacting the oral health profile were assessed using principal component analysis. Demographic factors for anxiety and TMD were examined using linear regression. The psychosocial and functional variables of the OHIP-TMD were compared with those of anxiety in the general regression system.

Results

The mean Oral Health Impact Profile (OHIP) value was 0.60, with a standard deviation of 0.61, indicating that the majority of respondents reported no or infrequent impacts on their oral health profile. Gender was a significant predictor of OHIP scores (P < 0.05), with females reporting higher scores. Despite these higher scores among females, the overall impact on oral health remained minimal for most respondents. The average PROMIS score was 11.12, with a standard deviation of 3.84. The PROMIS regression analysis on demographic variables yielded an R2 value of 0.092, F(4,78) = 5.691, with significance at P < 0.05. Gender emerged as the most significant predictor of PROMIS scores (P < 0.05), with females reporting higher scores. Once again, despite the higher scores among females, the overall impact remained low for most respondents. An analysis using a general linear model revealed a significant correlation between heightened anxiety levels and an increase in both psychosocial problems and physical function.

Conclusion

Although the majority of respondents reported minimal impacts on their oral health, anxiety remained a significant issue among female clinical dentistry students at the College of Dentistry in Aseer Province, Kingdom of Saudi Arabia. This anxiety was closely linked with psychological distress and impaired oral physical function. Beyond the realm of dental health, anxiety also had a profound effect on academic performance and student engagement. Therefore, addressing student anxiety is essential for enhancing overall well-being and academic success.
There’s the Rub: a narrative review of the benefits and complications associated with Vicks VapoRub use
Authors: Valido Austin , Boncompagni Ana Carolina , Tsang Michelle , Hume Patricia
Published: February 2025

Background

Vicks VapoRub (VVR) is a globally popular over-the-counter remedy marketed for use as a topical antitussive and analgesic. This review seeks to provide health professionals and care providers with a thorough summary of the benefits and complications associated with VVR use reported in the medical literature, identify off-label consumer behaviors that might increase the risk of health complications, and encourage further research into over-the-counter (OTC) medications.

Methods

Three databases—PubMed, Web of Science, and Embase—aided in creating a pool of 220 studies. For inclusion, studies had to discuss the therapeutic application of VVR in humans or a complication arising from its use.

Findings

Thirty-seven articles were found to meet inclusion criteria. Nine synthesis groups were created: three groups concern the product’s efficacy in regard to upper respiratory tract infection (URTI) symptom treatment (n = 7), onychomycosis treatment (n = 2), and in the context of wound care (n = 2). Six groups collate case reports that describe VVR-related complications, including VVR-associated lipid pneumonia (n = 11), ocular injury (n = 5), camphor toxicity (n = 5), dermatological conditions (n = 3), psychosis (n = 1), and respiratory distress (n = 1). The evidence around the use of VVR for the treatment of URTI symptoms and onychomycosis is limited and inconclusive. Even more limited cross-sectional data concerns its use in wound care. Many of the complications described in our study (e.g., multi-organ failure, ocular evisceration, severe pneumonia) involve product misuse. This review was designed to help guide patients on the safe and appropriate use of VVR (e.g., advising patients to avoid heating, ingesting, or intranasal/intrabuccal/ocular application of the product). In general, the severity of complications associated with misuse of VVR highlights the importance of complementary and alternative medicine disclosure and discussion.
Development and validation of a nomogram predicting multidrug-resistant tuberculosis risk in East China
Authors: He Fang , Wang Shu , Wang Hua , Ding Xing , Huang Pengfei , Fan Xiaoyun
Published: February 2025

Objective

Multidrug-resistant tuberculosis (MDR-TB) is a global health threat. Our study aimed to develop and externally validate a nomogram to estimate the probability of MDR-TB in patients with TB.

Methods

A total of 453 patients with TB in Anhui Chest Hospital between January 2019 and December 2020 were included in the training cohort. In addition, 116 patients with TB from Anhui Provincial Hospital Infection District between January 2015 and November 2023 were included in the validation cohort. Multivariable logistic regression analysis was applied to build a predictive model by combining the feature selected in the least absolute shrinkage and selection operator regression model. The C-index, calibration plot, and decision curve analysis were implemented to evaluate the predictive model’s discrimination, calibration, and clinical practicality. Then, logistic regression and least absolute shrinkage and selection operator (LASSO) models were constructed using R software, and the accuracy, goodness of fit, and stability of the models were verified using the validation cohort.

Results

Eight variables of patients with TB were selected using the best penalization parameter of the LASSO regression method, and the nomogram was established. The model displayed good discrimination with a C-index of 0.752 and good calibration. A high C-index value of 0.825 could still be reached in the validation cohort. The decision curve analysis demonstrated the clinical value of the model.

Conclusion

In this study, we constructed the LASSO regression model based on eight clinical traits and outcomes of laboratory tests, providing a novel insight for evaluating MDR-TB.
Challenges and Outcome of Infected Non Union of Bones using Masquelet Technique: A Case Series
Authors: Sahu Shivam , Venkataram V , Joseph Jomon De , Krishnan KR Ganesh
Published: February 2025

Infected non union of bones poses a significant challenge for orthopaedic surgeons due to the complexity of the problem, which includes bone necrosis, segmental bone loss, sinus tract formation, fracture instability, and scar adhesion of soft tissues. Bone infections remain a prevalent complication following fracture fixation. Effective management involves a multi-step approach, including debridement, soft tissue reconstruction, and bone stabilisation. The induced membrane technique, a two-stage process, has been successfully used to treat bone defects in both the upper and lower extremities. Here, four cases of infected non union treated using the Masquelet technique at various locations are presented. This technique involves a two-stage approach, where an induced membrane forms around a cement spacer, leading to the successful resolution of infection and bone union. Challenges encountered in these cases included recalcitrant infection, complex deformities, sclerotic bone ends, large bone gaps, shortening, and joint stiffness. Co-morbid factors such as smoking, diabetes, and hypovitaminosis D also influenced treatment choices and duration. All four cases treated with the Masquelet technique showed successful resolution of osteomyelitis, osseous union, and improvement in functional outcomes. Follow-up assessments revealed an average Visual Analogue Scale (VAS) improvement from 30 to 7.5, complete eradication of infection, and an average Lawton-Brody instrumental activities of daily living scale improvement from 13/23 to 21/23, with complete union of bone achieved in all four cases. Hence, it was concluded that the Masquelet technique is an effective approach for treating infected non union of bones, leading to the successful resolution of infection and bone union. Patience and perseverance are essential for achieving optimal outcomes.
CT Peritoneography for Identifying the Complications of Peritoneal Dialysis: A Case Series
Authors: Rajalakshmi P Prathiba , Srinivasan K , Jagdish K , Sudarsanam Hemanth , Murugan G
Published: February 2025

Peritoneal Dialysis (PD) is a commonly used method of renal replacement therapy for End-stage Renal Disease (ESRD), along with Haemodialysis (HD) and renal transplantation. However, various complications may develop early or late in the course of PD, causing patient morbidity, compromising the success of PD, and necessitating a change to HD. Imaging plays a crucial role in the diagnosis and management of PD-related complications, of which Computed Tomography (CT) peritoneography has proven to be an effective modality, allowing for elaborate visualisation of the peritoneal anatomy and the demonstration of small leaks and hernias. The authors hereby report a case series of three patients (41-year-old male, 62-year-old female and 31-year-old male) with PD-related complications, including abdominal wall, pericatheter and peritoneopleural leaks, highlighting the role of CT peritoneography in identifying them.
Evaluation of Formulated Suspension with Varying Concentrations of Pectin Derived from Mango (Mangifera indica Linn.) Peel and Acacia (Acacia Senegal L.) as Suspending Agents
Authors: Nyabuti Ian M.
Published: February 2025

Background: Nature has provided us a wide variety of materials to help improve and sustain the health of all living things either directly or indirectly. Pharmaceutical excipients used as suspending agents from natural sources are preferable due to their biocompatibility, abundance, and positive impact on the environment. Mangifera indica peel is excessively produced as a by-product of local food processing plants in Cebu. The objective of the study is to characterize the formulated suspensions with varying concentration of pectin from mango peel and acacia (Acacia Senegal L) as a suspending agent.
Objective: Determine the characteristics of the formulated suspensions with varying concentrations of pectin from mango peel and acacia as suspending agents
Methods: Paracetamol suspensions were prepared with mango pectin at concentrations of 2, 3 and 4 % and acacia (3%) as standard. The prepared suspensions were characterized based on sedimentation volume, degree of flocculation, flow rate, pH, viscosity and redispersibility.
Results and discussions: Mango pectin exhibited good sedimentation volume and viscosity-enhancing property, qualities which are important as a suspending agent in pharmaceutical suspensions.
Conclusion: The present review provided an overview of various aspects of natural suspending  agent like general  extraction  method, physicochemical  properties which supported the possible utility of mango peel derived pectin as a potential biomaterial in formulating pharmaceutical suspensions.
Post-Quantum Cryptography and Encryption Standards: Safeguarding Patient Data against Emerging Cyber Threats in Telemedicine
Authors: Balogun Adebayo Yusuf
Published: February 2025

Post-quantum cryptography (PQC) is a critical innovation for securing telemedicine patient data against emerging quantum computing threats. This study evaluates the vulnerabilities of existing encryption frameworks using data from the U.S. Department of Health & Human Services (HHS) Healthcare Data Breach Report. A weak correlation (r = -0.087) between encryption strength and breach severity suggests that while stronger encryption reduces the number of compromised records, factors such as system misconfigurations, phishing attacks, and insider threats remain significant contributors to data breaches. The study further benchmarks the performance of four NIST-approved PQC algorithms—Kyber, Dilithium, Falcon, and SPHINCS+—by analyzing encryption time, decryption time, key size, computational overhead, and storage requirements. Benchmarking data from the National Institute of Standards and Technology (NIST) is statistically evaluated using one-way ANOVA, which identifies significant performance differences among the PQC algorithms (p < 0.05). Falcon demonstrates the highest efficiency, with an encryption time of 17.16 ms, a decryption time of 18.59 ms, and optimized storage (2.05 MB), making it well-suited for real-time telemedicine applications. Institutional readiness for PQC adoption is assessed using the Healthcare Information and Management Systems Society (HIMSS) Cybersecurity Survey, identifying technical expertise (6.97/10) and infrastructure readiness (6.97/10) as the strongest adoption determinants. Based on the findings, this study recommends prioritizing Falcon for PQC adoption in telemedicine due to its superior efficiency, enhancing encryption key management protocols to mitigate insider threats, and strengthening cybersecurity infrastructure to address encryption misconfigurations. These measures will ensure that telemedicine systems remain secure, resilient, and capable of mitigating quantum-era cyber threats.
Effect of Foliar Application of Signal Molecules on Growth Characteristics and Rice Yield (Oryza sativa L.) on Salinity Resilience
Authors: K. R Shalini , M Ravi Babu , Ch Mukunda Rao , M Girija Rani , K Jayalalitha
Published: February 2025

Aims: The present study highlights the effect of foliar applied signal molecules on growth, yield and yield attributes of rice (Oryza sativa L.) under salinity stress.
Study Design:  Randomized block design.
Place and Duration of Study: Agricultural College Farm, Bapatla, Andhra Pradesh during kharif, 2023-24.
Methodology: Experiment was carried out with two contrast varieties (MCM103- Salt tolerant, as a check; BPT 5204- Salt susceptible) and with eight treatments viz., MCM 103 (Check variety) - T1, 0.25 mM/L of SNP - T2, 0.50 mM/L of SA -T3, 0.50 mM/L of BR -T4, 0.25 mM/L SNP+ 0.50 mM/L SA -T5, 0.25 mM/L SNP+ 0.50 mM/L BR -T6, 0.25 mM/L SNP+ 0.50 mM/L SA+ 0.50 mM/L BR -T7 and No spray control -T8 in three replications.
Results: The present study revealed that the foliar application of consortia, 0.25mM/L Sodium nitro prusside + 0.50mM/L Salicylic acid + 0.50mM/L Brassinosteroids (T7) showed better results under salinity stress of 4 dSm-1 in terms of improving growth besides increasing the yield and yield contributing characters in BPT 5204, a salt sensitive variety of rice.
Conclusion: The foliar application of 0.25 mM/L of Sodium nitro prusside + 0.50 mM/L of Salicylic acid + 0.50 mM/L of Brassinosteroids at before and after reproductive stages under soil salinity of 4 dSm-1 can minimize the effect of salinity stress in BPT 5204.
Enhancing Composting Efficiency: Thermophilic Lignocellulolytic Microbes for Bioconversion of Rice and Wheat Straw
Authors: Sahu Asha , Sankla Shivani , Bhattacharjya Sudeshna , Sahu Nisha , Bharati K. , Devi M. H.
Published: February 2025

Effective management of large amounts of crop residue from agricultural farms is crucial. Composting is a viable strategy for rice and wheat straw management, but traditional methods are inefficient due to the recalcitrant nature of the straw. This study aimed to identify and utilize thermophilic lignocellulolytic bacteria for efficient bioconversion of rice and wheat straw into compost. Samples were collected from hot springs in Madhya Pradesh and Chhattisgarh, leading to the isolation of 101 bacterial strains, of which 20 showed significant cellulolytic and lignolytic activity. Seven key isolates (five bacteria and one fungus) were further characterized and applied to compost rice and wheat straw in controlled conditions. The composts treated with these bacteria showed improved nutrient content and enzymatic properties compared to untreated compost. Specifically, in wheat straw, nitrogen (0.98%), phosphorus (1.49%), and potassium (1.37%) were higher than in the control (N: 0.69%, P: 0.99%, K: 0.86%). Similarly, in paddy straw, treated compost had higher N (1.17%), P (0.55%), and K (2.10%) compared to the control (N: 0.87%, P: 0.28%, K: 1.78%). The results demonstrated that these microbial isolates enhanced the composting process, improving compost maturity and nutrient content. This study recommends the formulation of these thermophilic lignocellulolytic bacteria for efficient crop residue composting. By reducing the reliance on straw burning, this microbial approach offers an eco-friendly alternative for sustainable agriculture and climate change mitigation.