bluuebunny/crossref_metadata_2025 huggingface dataset:
Nghiên cứu và đánh giá độc tính cấp, tác động kháng viêm của bài thuốc gia truyền Cao Khai sản xuất tại tỉnh Ninh Thuận
Authors: Nguyễn Thị Bạch Tuyết  , Hoàng Thị Phương Liên  , Lê Mộc Nhiên  , Mai Thị Ngọc Ánh  , Phạm Trí Nhựt  , Bạch Long Giang
Published: February 2024

Đề tài khảo sát độc tính cấp đường uống và tác dụng kháng viêm của bài thuốc gia truyền Cao Khai sản xuất tại tỉnh Ninh Thuận.Các thử nghiệm in vivo trên chuột nhắt trắng Swiss albino, 6-8 tuần tuổi, trọng lượng trung bình khoảng 22g. Khảo sát độc tính cấp đường uống của bài thuốc gia truyền Cao Khai liều 5000 mg/kg với thể tích 50mL/kg trọng lượng chuột, theo dõi tỉ lệ chết và biểu hiện độc tính cấp trong vòng 14 ngày. Sự thay đổi về trọng lượng cơ thể, chỉ số huyết học, chức năng gan và thận của chuột sẽ được ghi nhận vào cuối thử nghiệm. Tác dụng điều trị viêm của bài thuốc gia truyền Cao Khai với liều 400 và 800 mg/kg được xác định trên mô hình gây viêm bàn chân chuột nhắt bằng carrageenan 1%, mỗi lô 8 chuột. Diclofenac liều 5 mg/kg được sử dụng làm chất đối chứng. Kết quả cho thấy bài thuốc gia truyền Cao Khai không gây ra độc tính cấp đường uống ở nồng độ 5000 mg/kg, được xếp vào phân loại 6 – chất gần như không có độc tính theo GSH (Globally Harmonised System for Classification of Chemicals). Hơn nữa, bài thuốc gia truyền Cao Khai không gây ra sự khác biệt đáng kể trên trọng lượng chuột, chức năng tạo máu, chức năng thận, chức năng gan của chuột (p>0,05). Trên mô hình khảo sát tác động điều trị viêm, bài thuốc gia truyền Cao Khai thể hiện tác động làm giảm độ phù chân chuột đáng kể ở cả hai liều 400 và 800 mg/kg (p<0,05); nhưng khởi phát chậm hơn so với thuốc đối chứng diclofenac liều 5 mg/kg.
Khảo sát tính nhạy cảm của một số chủng Candida spp. phân lập từ miệng bệnh nhân ung thư với một số thuốc kháng nấm
Authors: Đinh Quang Long  , Phạm Bền Chí
Published: February 2024

Candida miệng là một bệnh phổ biến thường gặp ở những đối tượng bị suy giảm miễn dịch và đặc biệt nghiêm trọng với những bệnh nhân ung thư đang trải qua liệu pháp hóa, xạ trị. Để điều trị, rất cần sơ bộ định danh và khảo sát mức độ nhạy cảm của các chủng Candida spp. với các thuốc kháng nấm, nhằm hạn chế tình trạng kháng thuốc. Với 60 chủng Candida spp. phân lập được, bằng các thử nghiệm khảo sát hình thái khuẩn lạc trên môi trường CHROMagar Candida, khả năng sinh bào tử bao dày trên môi trường thạch bột ngô và thử nghiệm sinh ống mầm trong môi trường huyết thanh người, đã sơ bộ định danh đến mức loài được 51 chủng: 34 chủng C. albicans, 14 chủng C. tropicalis, 3 chủng C. krusei. Sử dụng phương pháp khuếch tán đĩa theo hướng dẫn của CLSI M44 – A để đánh giá mức độ nhạy cảm của 60 chủng Candida spp. với các thuốc kháng nấm clotrimazole, nystatin, amphotericin B, fluconazole và miconazol. Kết quả cho thấy, tất cả các chủng đều nhạy cảm với nystatin, không có chủng nào đề kháng với với amphoterin B, các thuốc nhóm azole bị đề kháng nhiều với với fluconazole (11,67%), miconazole (10%) và clotrimazole (5%). Trong các loài Candida spp. phân lập được, C. tropicalis có tỉ lệ đề kháng cao nhất.
Cloning human Benchwarmer gene (BNCH) harboring E164K in vector pcDNA3.1 by site-directed mutagenesis method
Authors: Nguyen Hoang Danh  , Vu Minh Thiet
Published: February 2024

Benchwarmer (BNCH) gene encodes an orphan transmembrane transporter belonging to the Major Facilitator Superfamily (MFS), facilitating the transport of ions, amino acids, simple sugars and recently lysolipids. The loss of BNCH function caused lethality in several animal models with neurodegeneration and senescence. At the cellular level, dysregulation of BNCH leads to adverse phenotypes of lysosome and also autophagy (i.e. dyshomeostasis, accumulation of carbohydrates and sphingolipids, and enlarged lysosome). However, the molecular function and ligand of BNCH protein remain to be unrevealed. This study aims to create a radical substitution change in human BNCH coding gene to knock out the protein functions. More specifically, lysine (K) was used to replace the glutamic acid residue 164 (E164K) which is conserved in many animals (fly, zebrafish, mouse and human) and this E164K mutation recapitulated BNCH mutant phenotype. In conclusion, BNCH harboring E164K (BNCH*) was successfully produced by site-directed mutagenesis and cloned into pcDNA.3.1 vector. The construct was transformed into E. coli OmniMAX and that provides a valuable cell assay to search for the molecular ligand of BNCH.
Phân lập vi nấm kháng vi sinh vật từ đất công viên ở Tp. Hồ Chí Minh
Authors: Mai Hà Thanh Bình  , Lê Quang Hạnh Thư
Published: February 2024

Nghiên cứu đã phân lập được 103 chủng vi nấm sợi từ đất công viên thuộc Tp.HCM, trong đó có 69 chủng được xác định thuộc chi Penicilliumsp., Aspergillussp., Trichodermasp., Mucorsp., Fusariumsp., Phomasp., Curvulariasp., Paecilomycessp., Cladosporiumsp., và các chủng chưa được xác định khác. Hoạt tính kháng vi sinh của vi nấm được khảo sát trên một số đối tượng như Staphylococcus aureus, MRSA, Streptococcus feacalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, C. glabrata và C. tropicalis. Kết quả khảo sát cho thấy 27 chủng có hoạt tính kháng khuẩn, gồm 10 chủng Penicillium sp., 11 chủng Aspergillus sp., 03 chủng Trichoderma sp. và 03 chủng khác và 12 chủng cho hoạt tính kháng nấm, gồm 02 chủng Penicillium sp., 01 chủng Aspergillus sp., 01 chủng Trichoderma sp. và 08 chủng khác. Đặc biệt, 03 chủng gồm Penicillium sp. T33, Aspergillus sp. G51 và H34 vừa kháng khuẩn vừa kháng nấm.Thêm vào đó, môi trường gồm cao nấm men và nước chiết ngô được chứng minh là phù hợp cho vi nấm sinh trưởng. Các kết quả trên cho thấy rằng vi nấm được phân lập từ đất có thể là nguồn tiềm năng cho việc khám phá các chất kháng sinh mới.
PEMANFAATAN BAHAN ALAMI UNTUK PENGEMBANGAN ECOPRINT DALAM MENDUKUNG KREATIVITAS SISWA DAN GURU SD N BUMIREJO
Authors: R. Angga Bagus Kusnanto  , Willy Lontoh  , Sujarwo  , Wiji Nur Azzahrah  , Pratiwi Nurussalamah
Published: February 2024

SDN Bumirejo Kecamatan Jayaloka merupakan kelompokbelajar yang aktif yang berada di kabupatenMusirawas. Kondisilingkungansekolah yang asri dan memilikiberagamdedaunanmenjadipendukungpembuatanecoprint di sekolahtersebut.Metode yang dilakukanyaitudengancarapemberianmateri, pelatihan dan pendampingan. Hasil yang didapatkandalampengabdian ini yaknipertama, guru dan siswa di SD N Bumirejocukupantusiasdalammengikutikegiatan, keduakegiatanpelatihan ini dapatmeningkatkankompetensisertakreativitas guru dan siswadalammembuatEcoprint yang ditunjukkan pada hasilkarya yang dibuat.
PENGABDIAN KEPADA MASYARAKAT (PKM) DENGAN PEMBERDAYAAN MASYARAKAT DESA SEMANGUS BARU MELALUI KKN TEMATIK KAMPUS MERDEKA
Authors: Eri Triharyati  , Yuli Nurhayati  , Fitria  , Irma Idayati  , Hardi Mulyono
Published: February 2024

Kegiatan   Pengabdian  Kepada Masyarakat adalah  merupakan salah satu tugas pokok seorang dosen dalam malaksanakan Tri Darma, yang diatur dalam Undang-Undang Republik Indonesia Nomor 12 Tahun 2012 Tentang Pendidikan Tinggi pada pasal 1 ayat 9 menyatakan bahwa Tridharma adalah kewajiban Perguruan Tinggi untuk menyelenggarakan Pendidikan, Penelitian dan Pengabdian Kepada Masyarakat, kemudian dijelaskan pula di ayat 11bahwa pengabdian kepada masyarakat adalah kegiatan civitas akademika yang memanfaatkan Ilmu Pengetahuan dan Teknologi untuk memajukan kesejahteraan masyarakat yang mencerdaskan kehidupan bangsa. Pada perguruan tinggi pelaksanaan pengabdian kepada masyarakat akan dilakukan oleh mahasiswa  yang dibimbing  dan didampingi oleh Dosen Pembimbing Lapangan (DPL) dalam bentuk Kuliah Kerja Nyata (KKN).
PENINGKATAN KEMAMPUAN BAHASA INGGRIS BAGI SISWA SD NEGERI 61 LUBUKLINGGAU: FUNENGLISH LEARNING THROUGH STORYTELLING
Authors: Maria Ramasari  , Ardayati
Published: February 2024

Pelaksanaan Pengabdian kepada Masyarakat (PKM) bertujuan untuk meningkatkan kemampuan Bahasa Inggris siswa di SD Negeri 61 Lubuklinggau. Halyang mendasari kegiatan ini terlaksana adalah usia emas sasaran untuk mempelajari bahasa.Diusia emas, siswa tingkat sekolah dasar dapat lebih optimal mempelajari bahasa Inggris baik secara lisan maupun tulisan. Siswa kelas II, III, dan IV merupakan sasaran untuk kegiatan ini, dimana siswa berusia 7 sampai 10 tahun. Karakteristik siswa direntang usia tersebut dikategorikan pada masa anak sudah matang bersekolah dan sudah lebih siap menerima pembelajaran bahasa.Selanjutnya, perkembangan digitalisasi yang dengan cepat masuk disemua elemen masyarakat termasuk pendidikan. Yang mana, semuanya menggunakan bahasa Inggris. Tuntutan berkomunikasi dengan menggunakan bahasa Inggris juga menjadi alasan terpenting terhadap pelaksanaan kegiatan PKM di SD Negeri 61 Lubuklinggau. Metode pembelajaran storytelling digunakan sebagai upaya agar siswa mampu menyampaikan perasaan, pikiran atau isi pesan dari sebuah cerita secara lisan. Melalui kegiatan storytelling, siswa dapat meningkatkan kecerdasan linguistik, emosional, komunikasi, dan memperkaya kreativitas dalam berimajinasi. Hasil dari pelaksanaan PKM adalah siswa mendapatkan fasilitas belajar bahasa Inggris yang berkelanjutan selama empat hari melalui kegiatan storytelling. Peningkatan progres kemampuan siswa sangat baik, siswa memiliki rasa percaya diri untuk tampil sebagai storyteller, dan siswa juga bisa menjadi pendengar yang kritis dalam mengambil pesan dari cerita yang disampaikan.
Los determinantes sociales de la salud y su influencia en la prevalencia y pronóstico de la EPOC: una revisión exploratoria
Authors: Whyte Isabel Asensio , Gimeno-Feliu Luis Andrés
Published: February 2024

Objetivo: el objetivo de esta revisión es estudiar el efecto que los determinantes sociales de la salud tienen sobre la prevalencia y pronóstico de la enfermedad pulmonar obstructiva crónica (EPOC).

Métodos: se ha hecho una revisión exploratoria (scoping review) de los artículos publicados entre 2013 y 2023, y una búsqueda bibliográfica en Pubmed. Se encontraron 31 artículos que cumplieran los criterios de inclusión.

Resultados: niveles educativos precarios, así como bajos ingresos económicos se relacionan con un aumento en el riesgo de EPOC, con incrementos del 44,9% y el 22,9% de los casos respectivamente. La dedicación a ciertos oficios, como la agricultura o los servicios de restauración, también aumenta la prevalencia de esta enfermedad y su impacto sobre la mortalidad. La soltería o viudez, el desempleo y vivir en áreas rurales con alta contaminación atmosférica son factores que se asocian a más hospitalizaciones, síntomas graves, menor productividad y mayor mortalidad. Las desigualdades sociales afectan el acceso a la atención médica y la adherencia al tratamiento. La EPOC es más común en hombres y en personas mayores, aunque algunos estudios muestran mayor riesgo en mujeres debido a su dedicación a las tareas domésticas y su exposición a sustancias contaminantes.

Conclusiones: determinantes sociales de la salud como el bajo nivel socioeconómico, la ocupación laboral, la contaminación doméstica o ambiental, el estado civil, lugar de residencia o dificultad de acceso al sistema sanitario actúan como factores de riesgo de la EPOC e influyen desfavorablemente sobre ella.

Palabras clave: enfermedad pulmonar obstructiva crónica, determinantes sociales de la salud, factores socioeconómicos, epidemiología, mortalidad.
Voices of Front-Line Physicians: Physician-Only Discussions
Authors: Doshi Ami , Fergerson Byron , Celebi Julie , Subramony Rachna , Minns Alicia , Tran Minh , Brubaker Linda
Published: February 2024

What is the best method for eliciting physician input and feedback and establishing bidirectional communication to address factors contributing to burnout, enhance a sense of professional community, and provide mental health support? Trained physician facilitators conducted small-group, physician-only discussions (PODs) that led to organized, actionable items and directly informed directions of departmental initiatives to reduce burnout.
Patient Experience and the CMO
Authors: Golbin Jason
Published: February 2024

Improving the patient’s experience is not easy because it often requires a change in the overall culture of the healthcare organization. Including patient experience as one of the core components of a high-reliability transformational program ensures the organization gives it the attention it requires and unites every employee and every physician around the goal.
The sacred music of Alberto Nepomuceno
Authors: Souza Ana Guiomar Rêgo
Published: February 2024

This paper discusses the sacred music of Alberto Nepomuceno according to the ultramontane Catholicism’, the Motu Proprio Tra le sollecitudini (1903) issued by the Supreme Pontiff Pius X (1903-1914), and the movement for the restoration of sacred music in Brazil in the first decades of the 20th century.The analytical approach is based on "discourse", that is, meanings constructed in the process of interlocution. It is also based on conceptions derived from Mikhail Bakhtin's thought as dialogism, performance spaces and discursive genre.
Women, participation and development: an important relationship in the search for better health care conditions
Authors: Alexandre Virginia Caroliny Silva , Neves Paulo Sergio da Costa
Published: February 2024

This paper aims to discuss women, participation and development in the practices of health care. We analyze women and the participation process into health, especially in the Health Councils and Conferences. The methodological approach is inspired in the ethnography, which involves fieldwork, writing and data analysis that take into account the time spent in the research, the involvement of the researcher during the whole process, and the moments of thoughts about the implications, we have had with the experience. The main idea of this work is to study the fieldwork on participation process in the health care system. We attended the meetings of some local health councils, conducted some interviews and attended the Health Conferences in Sergipe. This work has been developed in a problematic context in which health care has suffering budget cuts, reflected in the everyday practices of people who needs the Unified Health System. The focus of this work relays on the discussion of the important role women have to play to search for better health care conditions, not only in their families, but also in their neighborhood and other health care dimensions. The research has shown that women have an interesting political commitment that we seek to analyze and connect to the everyday practices of health. In spite of women are minority in parties and elections, they are the majority in the participation process on health care and the quality of life in the environment.
Alternative products in the budbreak of ‘eva rubi’ apple trees under subtropical climate conditions
Authors: Tico Bárbara Moura , De Oliveira Laise de Souza , Da Silva Clandio Medeiros , Assmann Joice Mari , Kiyota Norma , Pertille Rafael Henrique , Citadin Idemir
Published: February 2024

The apple tree requires chilling accumulation for budbreak. In locals where the chill accumalition is insufficient, chemical promoters are used to induce uniform budburst.  However, alternatives that minimize damage to the environment and applicator have been sought. Thus, the aim of this work was to evaluate the efficiency of hydrogen peroxide, pau-d'alho hydrolate, lime sulphur and neem oil in inducing budbreak of ‘Eva Rubi’ apple tree in agroecological cultivation. Different concentrations (0%, 5%, 10%, 15% and 20%) of pau-d'alho hydrolate and hydrogen peroxide were tested in Palmas and Pato Branco. Three additionals treatments were added in the Lapa region, where mineral oil 3%, Dormex 0.5%, and Dormex 0.5% + 3% mineral oil were applied. In 2023, a new experiment was carried out only in Pato Branco, repeating the same concentrations of pau d'alho hydrolate and including new treatments with lime sulphur (1, 2, 3 and 4%) associated with 3% Neem oil. Percentage of budbreak, fruit set, productivity, and fruit mass were evaluated. The treatments showed no difference in the analyzed variables for Pato Branco and Palmas. In Lapa, there was an improvement in the percentage of budbreak in the plants treated with 15% ‘pau d'alho’ hydrolate, but still insufficient to state that this product can be used as budbreak inducer, however it suggests potential use, requiring, for that, the continuity of research in other species and experimental conditions. No phytotoxic effect was observed for hydrogen peroxide and ‘Pau d’alho’ hydrolate at the studied dosages.
Analysis of the influence of the birth period on the body weight of Nelore cattle
Authors: Stamoulis Vassilikí Jaconi , Queiroz Guilherme Rocha , Bittar Joely Ferreira Figueiredo , Bittar Eustáquio Resende , Venturini Guilherme Costa
Published: February 2024

This study aimed to present the relationship between the birth period of beef cattle and the weaning weight of Nelore calves. A total of 260,832 Nelore animals from the database of the National Association of Breeders and Researchers (ANCP) were used. Out of this total, 130,001 were males (49.84%) and 130,831 were females (50.16%) of the Nelore breed conceived via artificial insemination. The animals used were born between the years 2014 and 2017 in the Southeast and Midwest regions in different months of birth. The evaluated characteristic was the weaning weight, and the assessment of these weights was defined at 210 days (standard weaning age). It was observed that there were no significant differences (P>0.05) in weaning weight between the years of birth. However, among the birth months, significant differences (P<0.05) in weaning weight were observed, with animals born between July and October (dry season) showing higher average weights. Therefore, it was concluded that the month of birth of Nelore calves can influence the weaning weight at 210 days of age, emphasizing that the weaning month is directly related to the weight gain of the animals. Therefore, a well-defined breeding season is necessary to control the ideal months for weaning heavier animals.
Work and community tourism: reflections on capitalist realism
Authors: Laborda Mayra , Scherer Elenise Faria
Published: February 2024

This theoretical essay aims to reflect on the concept of capitalist realism, by the author Mark Fisher, and its correlation with the context of work in Amazonian tourism, especially that carried out in conservation units (CU) by traditional communities. Fisher defines capitalist realism as a widespread belief in a defeatist way, which supports the idea that capitalism is the only viable economic and political system, with no alternatives even in the face of widespread dissatisfaction. In the context of Amazonian tourism, the proposal for community tourism (TC) stands out as an alternative to the mainstream, focusing on local development centered on the communities' endogenous resources. However, the essay argues that TC analysis often neglects working conditions and industrial relations. The question arises as to how it is possible to propose a sustainable alternative without considering workers and their interactions with natural resources. On a methodological level, this study is a theoretical essay, anchored in a bibliographical review with a critical perspective and qualitative nature. As a preliminary result, it points to the danger in hybrid forms of work organization in tourism, highlighting that, although they can be forged as anti-capitalist alternatives, they end up being co-opted by a logic of maximizing profits, harming the conservation of common resources and the well-being of workers. The hopelessness of alternatives preached by capitalist realism in the context of work encounters barriers in experiences aligned with the solidarity economy, shared management of common resources, cooperatives and collective forms of work/equal distribution of income. Although there are significant experiences in the counterflow of mainstream tourism, they are not capable of revolutionizing the horizon of Amazonian community tourism.
Reading, knowledge systems and textual processing
Authors: Silva Raimunda Nunes de Oliveira
Published: February 2024

The objective of this paper is to reflect on the importance of reading, as well as to reflect on the strategies used in the teaching-learning process of reading in Brazilian public schools. Thus, bibliographic studies were carried out with those on which the ideas of this article are based. From the 1970s onwards, Brazilian education went through a process of democratization. A school was created for all, however, the school grew in quantity, but the same did not happen in quality, because it was not prepared to give a quality education to all who had access to it. The present work is based on the studies of applied linguistics, based on authors such as: Isabel Solé, Angela Kleiman, Paulo Freire, and Ingedore Koch & Vanda Maria Elias. The cited authors make a distinction between reading strategies, classifying them as "cognitive" and "metacognitive". Cognitive comprises the unconscious procedures that the reader undertakes to understand a text. Metacognitive strategies, on the other hand, are procedures in which the reader has defined goals in mind, thus having conscious control of the actions he performs, that is, they are action strategies that can be consciously controlled.
Orthopedic injuries in mountain bike: an integrative review
Authors: Marques Daniela Ferreira , Gagno Júnior Fernando , Larentes Itamar de Abreu , Maslinkiewicz Alexandre , Felipe Thiago Renee , Santiago Uilian Sampaio
Published: February 2024

Mountain biking (MTB), also known as off-road cycling, refers to cycling on purpose-built trails in mountains and other unpaved surfaces. This study proposes an integrative review of the literature to highlight the most common orthopedic injuries associated with the practice of MTB. A review study was conducted, using periodicals published in the PubMed databases and the Virtual Health Library (VHL) as a basis. The results of this research were divided into: Table 1 (Characteristics of the productions included in the review) and Table 2 (Synthesis of the productions according to the main results). The prevalent injuries worthy of special attention are related to the upper limb, such as clavicle fractures and dislocations, in addition to wrist injuries, often resulting from falls and direct impacts. The importance of preventive measures, such as the appropriate use of protective equipment, including helmets, gloves and wrist protectors, is highlighted.
Impacts of the installation of the UFSM Campus nos the Environmental Characterization of the Passo da Areia Micro Basin in Cachoeira do Sul-RS
Authors: Schirmer Gerson Jonas , Cabral Ernani Arruda , Ongaro Marisa Dal , Wollmann Ana Rita Pereira
Published: February 2024

The present work aims to present the main characteristics of the Passo da Areia Micro Basin from the implementation of the UFSM campus in Cachoeira do Sul-RS, highlighting the possible impacts caused. For this, a bibliographic survey was carried out on the municipality and also on the specific area of study, as well as the construction of thematic maps addressing some physical characteristics of the Micro Basin. Another aspect addressed was the evolution of the occupation from the installation of the campus in 2014. This evolution was observed through satellite images and also with fieldwork. It was noticed that there is a greater probability of urban expansion for this area after the installation of the Campus, but the negative impacts can be minimized from actions originating from the Campus itself, mainly referring to proposals and projects developed by the courses of Architecture and Urbanism, Transport and Logistics Engineering and Agricultural Engineering aimed at the local community. Thus, it can be said that the implementation of this Campus contributes positively to the ordering of the landscape of the Micro Basin under study.
Relationship between aging and the labor market: cooperativism as a strategy for social inclusion of the elderly in the paranaense context
Authors: Nespolo Juliana Mara , Barauna Bruno Diego , Cenzi Neri Luiz , Outeiro Edison Luiz , Bernartt Maria de Lourdes , De Meza Maria Lucia Figueiredo Gomes
Published: February 2024

"The aging of the population is a widely observed structural phenomenon in modern societies. With the increase in life expectancy, there has been a significant growth in the number of elderly individuals worldwide. This demographic shift poses significant challenges of a social, political, and economic nature, requiring special attention regarding the active maintenance of older individuals in the labor market. The present study aims to reflect on the current scenario of population aging in Brazil and the contribution of cooperativism to active aging and social inclusion of the elderly. Through a descriptive and exploratory research approach, utilizing bibliographic procedures, the study culminated in identifying cooperativism as a crucial strategy for promoting active aging and constructing a more inclusive society.
Global librometric analysis of research on Ascaris lumbricoides and its relationship to nursing practices associated with health education
Authors: De Sousa Neto Antonio Rosa , Aulet Eliana Soledad Eulacio , Ferreira Josie Haydée Lima , Cardoso Osmar de Oliveira , Heck Thiago Gomes , De Aliaga Kelly Myriam Jiménez , Moura Maria Eliete Batista , De Freitas Daniela Reis Joaquim
Published: February 2024

It is estimated that approximately 820 million people are infected with Ascaris lumbricoides, and ascariasis infections are over 1.33 million, which is worrying as it can lead to morbidity by impairing the consumption of nutrients, as well as digestion and absorption due to intestinal obstruction. Knowing what research has been done on the subject is important for thinking about future steps to control and prevent helminths and their pathology. Evaluating international participation in research on A. lumbricoides with a view to highlighting the subject and associating these results with nursing practices related to health education, in order to help identify important aspects of the disease caused by this pathogen and to draw up educational interventions in communities, as well as obtaining support for future research. This is a descriptive, bibliometric study with a quantitative approach, carried out in five steps: research designer, compilation of bibliometric data, data analysis, data visualization and interpretation of results. To retrieve the data, scientific articles were searched for in the Web of Science™ (WoS) database. The search term used was "Ascaris lumbricoides". All the information available was downloaded in text file format for analysis using the RStudio Desktop software, linked to the R software (v.4.2.1). The Bibliometrix R package and its complementary graphical web interface, Biblioshiny, and the VOSviewer software were used for analysis. We analyzed 740 articles on A. lumbricoides, published between 1945 and 2023, in 324 scientific journals; Parasitology, Transactions of the Royal Society of Tropical Medicine and Hygiene and Experimental Parasitology were the journals that ranked first for publications on the subject, and the Journal of Cell Biology had the most cited article to date. It was observed that the years that produced the most were 2010 and 2011, both with 17 articles, with the peak number of citations being 510 per year, occurring in 2013. The United States is at the top of the article production ranking, and is also the country with the most collaborations, with Brazil in second place. It was possible to identify global research trends on A. lumbricoides, and it was shown that there is little research on the subject. In the long term, the data obtained can support further research and the development of strategies aimed at both prevention and the control and management of cases of infection by the parasite, on an ongoing basis, through health education; in this regard, nursing professionals are fundamental, as they are the main agents dispersing knowledge to prevent diseases such as ascariasis in the low-income population.
A színjátszás különböző terei az 1840-es években : Petőfi Sándor színészi állomásai: vidéki vándortársulatok és a Nemzeti Színház
Authors: Szanyiszló Lilla
Published: February 2024

Petőfi Sándor vándorszínészi működéséről, színészi próbálkozásairól meglehetősen sokat tudunk. Fekete Sándor kismonográfiában, Rajnai Edit pedig egy mintaszerű tanul- mányban foglalta össze ennek az összesen körülbelül két évnyi időszaknak a történéseit.1 A témával foglalkozni kívánó kutató így leginkább arra vállalkozhat, hogy a narratíva kialakításakor, az események újramondásakor az eddigiektől eltérő súlyozással él, más szövegeket és forrá- sokat helyez középpontba, s olyan mozzanatokat emel ki, amelyek eddig nem kerültek szóba vagy kevés figyelmet kaptak. Új nézőpontként merülhet fel a vidéki társulatok társadalmi összetételének, a tagok életkorának, iskolázottsá- gának bemutatása, az, hogy Petőfi kikkel, milyen emberek között dolgozott és élt vándorszínészi működése idején. Nem kevésbé lehet érdekes a Nemzeti Színházzal való színészi kapcsolatának vizsgálata, egyrészt annak végiggondo- lása, hogy milyen helyzetbe kerülhetett volna, ha barátai ösztönzésének en- gedve 1843 nyarán megpróbál bekerülni a társulatba, másrészt 1844. októberi fellépésének körülményei, több szempontú kontextualizálása. Ezekhez fogó- dzót elsősorban a Nemzeti Színház fennmaradt iratanyaga nyújt, amelyből még az is kideríthető, hogy pontosan hányan látták a költőt Gémesi nótárius szerepében.
MODELLING OF SILVER CLUSTER COMPLEXES WITH ANTIBACTERIAL MEDICATION DIOXIDINE
Authors: SOLOVIEV A.V. , ERMILOV A.YU. , MOROSOV YU.N. , SHABATINA T.I.
Published: February 2024

By the method of the electron density functional in the variant DFT/B3L-YP5 the structures of small silver clusters (Agn, n = 1-3, 13) and their molecular complexes with antibacterial medication dioxidine (Dx) were calculated. The features in the geometric structure and energy of the interaction “metal cluster - dioxidine ligand” depending on the size (nuclearity) of the metal cluster are considered. For small clusters (n = 1-3), the tendency of metal coordination to only one of the oxygen atoms of the ligand molecule was revealed. The most stable are the complexes of silver trimers Dx-Ag3 and the icosahedral cluster of silver Dx-Ag13. These complexes are coordinated by two oxygen atoms of the hydroxyl groups of the dioxydine molecule at once. The difference between the obtained optimized structures of the silver-dioxidine complexes and the previously studied silver complexes with hydroxide ligands, for which the hydrogen atom of the hydroxyl group of the ligand is displaced during interaction, is shown.
INFLUENCE OF POLYVINYL ALCOHOL ON THE STABILITY OF AQUEOUS DISPERSIONS OF NANODIAMONDS
Authors: SOBOLEVA O.A.
Published: February 2024

The stability of aqueous dispersions of detonation nanodiamonds (ND) in the presence of polyvinyl alcohol (PVA) has been studied. It has been established that PVA additives with a concentration above 0.1 wt.% cause the formation of aggregates. To increase the stability of ND dispersions, it was proposed to add a stabilizer, an anionic surfactant sodium dodecyl sulfate (SDS), into the system. As a result of the simultaneous action of the SDS-PVA mixture, the aggregation stability of aqueous dispersions of ND increases markedly; the particle size in the dispersions does not change for several days.
SIMULTANEOUS DETERMINATION OF CHLORHEXIDINE,
р-CHLORANILINE, TRICLOSAN, DIBUTYL PHTHALATE, AND IONOL
IN ANTIBACTERIAL LIQUID BY HPLC WITH SPECTROPHOTOMETRIC
DETECTION
Authors: Pirogov Andrey Vladimirovich , Staroverov Sergey Mikhailovich
Published: February 2024

The article is devoted to the development of a simple chromatographic method for the simultaneous determination of the well-known antiseptics – chlorhexidine and triclosan – in new generation of antiseptic liquids. The
dependences of the retention times of chlorhexidine and triclosan on the acetonitrile
concentration in the mobile phase (from 30 to 60%) and pH (in the range of 3–8
units) for sorbents Luna C18, Nucleosil CN, Diaspher C4 were studied. A perfect
separation of chlorhexidine, p-chloraniline (the most toxic product of chlorhexidine
decomposition), dibutylphthalate (as a component of cosmetic alcohol), triclosan and
ionol (butylhydroxytoluene, BHT, E321 – antioxidant agent) during 20 minutes in the
gradient elution mode on the column with a domestic sorbent Diaspher C4 has been
demonstrated.
Ngomong Santun ala Wong Pandhalungan Jember
Authors: Ahmad Rifa'i  , Agus Santoso
Published: February 2024

Banyak orang berpendapat kesantunan adalah urgensi abad ini. Sebelum kita membahasnya mari kita runtut terlebih dahulu. Berbicara tentang kesantunan, adab, hingga budi pekerti ini identik dengan individu (personal). Individu biasanya adalah bagian dari kelompok kecil dalam kehidupan masyarakat. Kelompok kecil ini yang nantinya akan menjadi bagian dari suatu kelompok dalam skala yang lebih besar atau biasa kita sebut suatu bangsa. Bangsa Indonesia pada jaman kolonial hingga pradigital dikenal sebagai bangsa dengan kesantunan, adab, hingga budi pekertinya yang luhur. Indentitas itu yang akan selalu tergambar jelas dalam hati dan pikiran warga negara Indonesia, hal itu juga yang membuat bangsa Indonesia seakan-akan mempunyai rambu-rambu khusus yang ada dalam diri untuk mengontrol prilaku dalam kehidupan sehari-hari. Namun, identitas itu kini kembali dipertanyakan eksistensinya, bahkan ada sebuah penelitian yang menggambarkan masyarakat indonesia adalah masyarakat yang paling tidak santun se-Asia Tenggara. Tentu hal itu bagai banjir di musim kemarau, cukup mengejutkan. Memang penelitian tersebut hanya bersumber dari pengamatan terhadap masyarakat pengguna media sosial di Indosensia atau lebih dikenal dengan sebutan netizen +62. Bagi saya yang seorang pemikir tentu tidak akan begitu saja percaya terhadap klaim tersebut, harus ada kajian dan telaah lanjutan untuk kita dapat mengetahui realitasnya. Namun, bagi masyarakat awam tentu ini ibarat “di pukul dari arah belakang”, ia bisa tidak tahu siapa pemukulnya atau bahkan sebab kenapa ia di pukul.
Nah, kira-kira gambaran awal ini yang akan penulis bawakan sebagai pemantik semangat untuk melakukan telaah lebih lanjut. Ada beberapa masalah menarik yang akan penulis angkat yang tentu juga hal ini dapat mewakili kegelisahan kita bersama, diantaranya: 1) Apakah benar adab dan kesantunan masyarakat indonesia sudah benar- benar luntur? 2) Apakah kesantunan masyarakat Indonesia sudah terwakili oleh netizen indonesia? 3) Apakah karakter masyakat indonesia masih terjaga dan lestari hingga saat ini dan pengguna media sosial Indonesia tidak bisa begitu saja menjadi representasi masyarakat indonesia dalam dunia nyata, Atau 4) Jangan-jangan adab, kesantunan, hingga budi pekerti indonesia sedang menjadi objek propaganda bangsa asing untuk menghilangkan identitas positif masyarakat Indonesia melalui isu-isu provokatif. Nah jawaban lengkap, lugas, dan tuntas akan penulis sajikan berdasarkan pengamatan, telaah, dan wawancara mendalam yang  nantinya akan disajikan secara menarik, rapi, dan cantik dalam buku ini. Selamat membaca!
Efectos secundarios de la inmunización contra SARS-CoV2 en población adulta
Authors: Orellana-Suarez Kleber Dionicio , Mėrchan-Córdova Olivo Joel , Pozo-Tomalá Diego Gerardo
Published: February 2024

El virus SARS-CoV2 originó una de las pandemias con gran repercusión en la salud de los habitantes a nivel mundial, el desarrollo de las vacunas para la inmunización fue una de las medidas preventivas con más énfasis y predominio para minimizar la incidencia de los casos y los efectos graves de aquel virus de infección respiratoria. La presente investigación tuvo como objetivo analizar los efectos secundarios de la inmunización contra SARS-CoV2 en población adulta, implementando un diseño de estudio documental, de tipo explorativo y descriptivo mediante revisión bibliográfica sistemática en bases de datos internacionales y nacionales. Los efectos más predominantes fueron; malestar general al cuerpo, cansancio dolor en el sitio de la punción, fiebre, es decir, síntomas similares a la infección o resfriado común (vacuna Pfizer, AstraZeneca, Janseen, Cansino, Sputinik y Sinovac). Se identificó taquicardia en Pfizer y un caso de parálisis facial en AstraZeneca. El grado de eficacia del proceso de inmunización identificado en los estudios varió del 56% al 95% como prevención a la enfermedad, hospitalización del 86% al 98% y muerte del 17% al 97%. Las principales tipos de vacunas identificadas fueron Pfizer-BioNTech (BNT162b), Oxford-AstraZeneca (ChAdOx1), Johnson & Johnson (Ad26.COV2.S), Moderna (mRNA-1273/83), Sinopharm (BBIBP-CorV), Sinovac (CoronaVac), algunas basadas en vectores de adenovirus, proteínas o de ácidos nucleicos ARNm. Se concluye que, los efectos de la inmunización en su mayoría destacan los síntomas leves o propios de la infección, y muestra un grado de eficacia satisfactorio ante la enfermedad respiratoria.
Infecciones de vías urinarias causadas por Klebsiella pneumoniae y sus mecanismos de resistencia en Latinoamérica
Authors: Lucas-Parrales Elsa Noralma , Solórzano-Vera Erika Yamileth , Samaniego-Solis Nayeli Isabel
Published: February 2024

Las infecciones de vías urinarias son consideradas un problema de salud pública, causadas por bacterias como Klebsiella pneumoniae, y la resistencia adquirida por el uso excesivo e inadecuado de antibióticos; el objetivo principal fue analizar las infecciones de vías urinarias causadas por Klebsiella pneumoniae y sus mecanismos de resistencia en América Latina. Metodología: consistió en un diseño cualitativo, el tipo de investigación de revisión sistemática, de artículos publicados entre 2019 a 2023 en idioma inglés y español, se utilizaron bases de datos científicas como: PubMed, SciELO, Google Académico, Elsevier; se emplearon los operadores booleanos “and”, “or” y “not”; se evaluaron los artículos mediante el flujograma de PRISMA para su legibilidad. Resultados: las infecciones de vías urinarias causadas por Klebsiella pneumoniae tuvieron mayor frecuencia en los países: Colombia 15,49% (1609 personas), Ecuador 7,1% (299 personas), Perú 4,48% (63 personas) y Paraguay 14% (148 personas); la susceptibilidad, fue a tigeciclina y colistina que presentaron resistencia del 100%, las penicilinas y las cefalosporinas resistencia mayor al 50%; los carbapenémicos y aminoglucósidos presentaron sensibilidad mayor al 90%; los mecanismos de resistencia natural fue las betalactamasas de espectro extendido BLEE, las carbapenemasas KPC y las metalobetalactamasas MBL. Conclusión, las infecciones de vías urinarias causadas por Klebsiella pneumoniae son muy frecuentes, presentan resistencia natural y adquirida que se producen por el uso inadecuado de antibióticos.
Microalbuminuria y su efectividad en el diagnóstico precoz de insuficiencia renal
Authors: Jenniffer-Cañarte Murillo , Chinga-Vinces Thayjin Milena , Orosco-Rosado Dasley Dayanna
Published: February 2024

La microalbuminuria, al indicar daño renal incipiente, desempeña un papel crucial en el diagnóstico precoz de la insuficiencia renal, especialmente en pacientes con factores de riesgo y enfermedades crónicas. Su identificación temprana permite intervenciones oportunas y personalizadas, mejorando el pronóstico y previniendo complicaciones graves. El objetivo principal fue evaluar la microalbuminuria y su efectividad en el diagnóstico precoz de insuficiencia renal. La metodología adoptó un diseño, donde se seleccionaron artículos publicados en los últimos 5 años. La estrategia de búsqueda abarcó bases de datos científicas y se emplearon palabras clave como "diagnosis," "microalbuminuria," "Diagnostico," "Daño renal," y "Precoz." Los resultados demostraron que la insuficiencia renal afecta principalmente a adultos mayores, con una mayor incidencia en personas mayores de 60 años. Los métodos efectivos para diagnosticar la microalbuminuria incluyen técnicas semicuantitativas y cuantitativas, como la tira reactiva de orina, electroforesis, inmunofelometría e inmunoturbidimetría.  La determinación de microalbuminuria fue afectada por factores como un ayuno insuficiente, contaminación de la muestra (por flujo vaginal o heces en la mayoría de casos), mal control glucémico, estado de hidratación e infección urinaria y que la microalbuminuria es efectiva en el diagnóstico temprano de la insuficiencia renal, pero su eficacia disminuye a medida que avanza la enfermedad. En conclusión, la microalbuminuria demostrando su capacidad para identificar insuficiencia renal de manera precoz, pero, su eficacia tiende a disminuir en etapas avanzadas (estadios superiores a 3) de la insuficiencia renal, lo que sugiere la necesidad de buscar otros estudios más efectivos para diagnosticarla en esas fases.
Prevalencia, factores de riesgo y diagnóstico del cáncer de tiroides en la población de América Latina
Authors: Bravo-Villalta Ricky Ronaldo , Zambrano-Rodríguez Klever Alexander , Durán-Cañarte Augusto Leonel
Published: February 2024

El cáncer de tiroides es la malignidad más común que afecta al sistema endocrino, y en las últimas décadas, se ha observado un aumento progresivo de su aparición en múltiples regiones y países alrededor del mundo. El objetivo principal es analizar la prevalencia y pruebas de diagnóstico del cáncer de tiroides en la población de América Latina. Metodología: Revisión de tipo narrativo documental. Se llevó a cabo con bases de datos como; Scielo, Pubmed, Medigraphic, Elseiver. Los resultados resaltan la prevalencia del cáncer de tiroides entre países, como Argentina teniendo la tasa más alta y Perú la más baja. La ecografía y la biopsia por punción son las pruebas de diagnóstico más comunes en todos los países, mientras que Chile y Uruguay también utilizan la gammagrafía tiroidea. Además, se identifican factores de riesgo comunes como la exposición a la radiación y los antecedentes familiares, junto con otros como la dieta, la edad, el sexo, factores hormonales, sobrepeso, consumo de tabaco, deficiencia de yodo, nódulos tiroideos y enfermedades autoinmunes. Finalmente, la prevalencia de cáncer de tiroides en América Latina tiene un espectro que podría ir de 0.010% A 0,50% aprox por cada 100000 habitantes, las pruebas de diagnóstico más utilizadas en la población de América Latina para el cáncer de tiroides son la ecografía de tiroides y la biopsia por punción con aguja fina, los factores de riesgo asociados al cáncer de tiroides en la población de América Latina, son la exposición a la radiación, la dieta y los antecedentes familiares.
Hipertransaminasemia prolongada en pacientes con hepatitis: una visión global de la utilidad clínica para el diagnóstico
Authors: Merchán-Villafuerte Karina Maricela , Carreño-Mera Gloria Marissa
Published: February 2024

El presente estudio aborda la problemática de la hipertransaminasemia prolongada en pacientes con hepatitis crónica a nivel global. Mediante una metodología documental, se realizó un estudio descriptivo con enfoque explicativo para analizar la prevalencia de este fenómeno y su etiología en diferentes regiones geográficas, se tomó a consideración artículos científicos originales y revisión de páginas con prestigio académicos, sobre el tema planteado, incluyendo bases de datos de realce académico como PubMed, Springer, Biomed Central, Scielo, Science Direct durante los últimos 7 años, como resultado principal encontramos que aproximadamente el 60% de los pacientes con hepatitis crónica presentan niveles elevados de transaminasas persistentes, con variaciones significativas entre distintas zonas geográficas. Las principales causas identificadas incluyen infecciones virales crónicas, especialmente el virus de la hepatitis B y C, así como la enfermedad del hígado graso no alcohólico. El tratamiento y manejo de la hipertransaminasemia se basan en enfoques terapéuticos específicos, ajustes en el estilo de vida y un seguimiento regular de la función hepática. Se resalta la importancia de identificar y controlar factores de riesgo, así como la necesidad de una atención individualizada para optimizar los resultados clínicos. Se recomienda investigar de manera prospectiva y controlada para profundizar en el conocimiento sobre la prevalencia y etiología de la hipertransaminasemia prolongada en diversas poblaciones.
RESEARCH AND SCIENTIFIC DEVELOPMENT: THE ROLE OF FUNDING AGENCIES FOR TECHNOLOGICAL ADVANCEMENT IN BRAZIL
Authors: Melo Gilcerlandia Pinheiro Almeida Nunes , De Oliveira Roselia Cristina , Da Silva Calcinéa Marvila de Oliveira , Silva Eloísa Helena , Da Silva Rosilene Alves , De Souza Rívea Mary Alves , De Andrade Iselda Alves Brito , Da Silva Weslania Andresa Vieira
Published: February 2024

One of the main objectives of scientific production is to contribute to the scientific and technological development and growth of a country. To achieve this, research must go through several stages until it is published and subsequently applied in a concrete way. Therefore, it is important to know the trajectory of such studies. In this sense, the value of funding agencies in scientific production stands out. Therefore, this article provides a brief discussion about the production of scientific knowledge in research centers and the role of funding agencies in promoting them. To this end, strictly bibliographical research was carried out using articles in magazines and periodicals in order to provide readers with a perspective on funding institutions and their importance for the scientific and technological world.
Stabilisasi Tanah Lempung Menggunakan Palm Oil Fuel Ash (POFA) dan 20% Kapur Dolomit (CaMg(CO3)2) Ditinjau dari CBR dan Kuat Tekan Bebas
Authors: Nasution Derry Wiliyanda , Hastuty Ika Puji , Roesyanto Roesyanto , Anisa Selfi
Published: February 2024

Tanah lempung merupakan salah satu jenis tanah yang kurang baik bila dijadikan tanah dasar karena memiliki daya dukung dan kuat geser yang rendah, namun memiliki tingkat kompresibilitas yang tinggi. Usaha untuk memperbaiki kondisi tanah tersebut dengan stabilisasi. Pada penelitian ini dilakukan stabilisasi tanah secara kimiawi dengan mencampurkan bahan tambahan POFA (Palm Oil Fuel Ash) dan Kapur Dolomit (KD). Penelitian ini dilakukan untuk mengetahui nilai index properties, nilai CBR Laboratorium, dan nilai kuat tekan bebas (UCT) dari tanah asli setelah penambahan bahan stabilisasi. Persentase bahan stabilisasi yang digunakan adalah POFA sebanyak 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, 18%, 20% dan KD sebanyak 20% di setiap variasinya. Berdasarkan hasil penelitian, nilai CBR paling tinggi terjadi pada variasi campuran 12% POFA + 20% KD yaitu sebesar 8,26%. Berdasarkan pengujian Kuat Tekan Bebas, diperoleh nilai kuat tekan tanah (qu) maksimum dari semua variasi campuran terdapat pada campuran 12% POFA + 20% KD yaitu sebesar 2,945 kg/cm2. Oleh karena itu, penggunaan POFA dan KD dinilai mampu meningkatkan stabilisasi tanah lempung.