bluuebunny/crossref_metadata_2025 huggingface dataset:
Moon Phases, Mood and Stock Market Returns
Authors: Floros Christos , Tan Yong
Published: March 2013

We employ recent data from 59 international emerging and mature stock markets to provide new evidence of a lunar cycle (full and new moon) effect on their stock market returns. Using a threshold generalised autoregressive conditional heteroscedasticity (TGARCH) model, we further examine the linkages between efficient-market theory, calendar-related effects and investors’ mood resulting from moon phases. The empirical results show significant full moon effects in six markets, and significant new moon effects in eight markets. In line with the theory, we report significant positive effect of new moon on stock market returns in five cases (UK, Switzerland, Bangladesh, Chile and Cyprus), while a negative effect of full moon is reported for the case of Jordan only. In addition, we find that lunar effects are strongly influenced by the calendar anomalies (Monday effect and January effect); several markets—mostly emerging markets—show evidence of full/new moon effects as well as Monday/January effects (Bangladesh, Brazil, Chile, Tunisia, Belgium, Cyprus). Further, we prove that the lunar phases are stronger outside America. These findings are recommended to investors, financial managers and analysts dealing with international stock indices.

JEL Classification: G02, G14, G15
“Feeling Unsafe”
Authors: Saimon Rosalia , Choo Wan Yuen , Bulgiba Awang
Published: March 2013

Understanding the factors influencing physical activity (PA) in the Asia-Pacific region is critical, given the high prevalence of inactivity in this area. The photovoice technique explores the types of PA and factors influencing PA among adolescents in Kuching, Sarawak. A total of 160 photographs were collected from participants (adolescents, n = 22, mean age = 14.27 ± 0.7 years, and parents, n = 8, mean age = 48 ± 6.8 years). Data analysis used constant comparison methods of a grounded theory. The Analysis Grid for Environments Linked to Obesity was used to categorize PA factors. Study findings were centered on the concept of safety, facilities, parental restriction, friends, cultural traits, media, community cohesiveness, and weather. The central theme was “feeling unsafe” when being outdoors. To promote PA behavior, provision of PA facilities needs to be supported by other programs that build on peer support, crime prevention, and traffic safety, together with other educational campaigns.
Spatial point pattern analyses of Bovine viral diarrhea virus infection in domestic livestock herds and concomitant seroprevalence in wild white-tailed deer (Odocoileus virginianus) in New York State, USA
Authors: Kirchgessner Megan S. , Dubovi Edward J. , Whipps Christopher M.
Published: March 2013

Bovine viral diarrhea virus (BVDV) is an economically important disease of domestic cattle that is capable of infecting cervids. A first step in the formulation of a regional BVDV management plan is a local assessment of the likelihood of pathogen transmission from wildlife to domestic livestock. To achieve this, blood samples were collected from hunter-harvested white-tailed deer ( Odocoileus virginianus) throughout New York State in the fall of 2009 and 2010. The SVANOVIR BVDV p80-AB enzyme-linked immunosorbent assay (ELISA; Svanova Biotech AV, Uppsala, Sweden) was used to screen sera for anti-BVDV antibodies. Because this ELISA is not validated for use in white-tailed deer, sera that tested positive were tested again using serum neutralization to verify the presence of antibodies. Spatial data describing the geographic location of BVDV antigen–positive cattle and camelid herds and BVDV-seropositive white-tailed deer were analyzed via the dual kernel density estimation method. In white-tailed deer, 7.48% (80/1,069) were BVDV-seropositive, whereas 3.43% (144/4,195) of tested herds were positive for BVDV antigen. An exploratory cluster analysis revealed 1 significant cluster of BVDV antigen–positive herds and 2 significant clusters of BVDV-seropositive deer. There was no spatial overlap between the clusters. The spatial point pattern and exploratory cluster analyses suggest that BVDV is maintained independently in domestic livestock herds in the western part of the state and in the white-tailed deer population in the northwestern part of the state.
Biomechanical Comparison of Metatarsal Head Designs in First Metatarsophalangeal Joint Arthroplasty
Authors: Schneider Tim , Dabirrahmani Danè , Gillies Ronald M. , Appleyard Richard C.
Published: March 2013

Background:

Arthritis of the metatarsophalangeal (MTP) joint is characterized by loss of MTP joint range of motion (ROM) and pain. Joint arthroplasty is one treatment option, and while results can be satisfactory, there is still room for improvement. The aim was to use cadaveric model to compare the sagittal kinematics and articulating contact properties of 4 different first metatarsal head designs of an MTP joint implant.

Methods:

Six cadaveric feet were each prepared with a single modular first MTP joint total arthroplasty. A standard cyclic load, which induced hallux dorsiflexion, was applied and motion measured from high resolution images. Contact behavior was collected simultaneously using a pressure transducer. Data collected compared the native joint with 4 different reconstructed cases. Each reconstructed joint used a different metatarsal-head-component while reusing the same phalangeal component to compare the 4 alternative metatarsal head designs.

Results:

All reconstructed joints displayed greater ROM compared with the intact joint. Of the 4 metatarsal head components, the grooved, anatomical design demonstrated the greatest dorsiflexion when compared to the standard design, 31.6 degrees (SD ± 8.6 degrees), P < .05. All reconstructed joints displayed contact areas lower than the intact (~50%, P < .001). The grooved metatarsal-head-component experienced the least contact force ( P < .015), and the eccentric component underwent the greatest contact pressure ( P < .05) when compared to the intact case.

Conclusions:

In this study of a first metatarsophalangeal joint replacement design, ROM was shown to be better for the more anatomically designed metatarsal head, while contact properties did not vary across different designs.

Clinical Relevance:

This information may be useful in the development of new metatarsal components.
Swarms of Technology, Melodies of Life
Authors: Iveson Richard
Published: March 2013

This article considers Jussi Parikka’s Insect Media: An Archaeology of Animals and Technology and its place within the broader context of neomaterialist philosophy. The question of Insect Media, and indeed of neomaterialism more generally, can be summarized as follows: how might one open oneself to radically alien durations, while remaining politically sensitive to the concomitant risk of technocapitalist capture? Moving through the wide range of subjects engaged with by Parikka, from entomology and cinema to the most advanced forms of programming ecologies, I focus on Parikka’s organizing notion of insects as figuring the molecular disruption of the phantasmatic molar body. For Parikka, it is the swarm that serves as his privileged example, which he locates at the intersection of animal studies, posthumanism and media theory. After outlining Parikka’s important reworking of Bergson’s conception of instinct, understood as ‘intensities’, which functions equally well within the domain of new media, and some of its implications for neo-Darwinism, I then consider Parikka’s ‘melodic’ conception of both nature and technology. Such a conception, I suggest, is problematic in its conflation of nonhuman animals with, for example, software, technologies, viruses and parasites. This in turn puts into question Parikka’s ‘use’ of insects in relation to the claim, common to neomaterialism in general, to have moved beyond an anthropocentric viewpoint. Rather, I argue, such a conception rebuilds a humanist enclosure, albeit one in which, following Guattari, subjectivity can no longer be identified with the individual. Insofar as Parikka designates every nonhuman animal and every machine as beings prior to language and thus prior to intelligence, the non-unitary subject is as a result restricted to the experiencing human subject. This, as Eugene Thacker points out, has serious political implications as regards the attribution of value, or not, to this or that life. However, insofar as Parikka considers instinct as habitual rather than as predetermined and, moreover, extends it to technical beings, I suggest that such a placing of instinct as ‘prelinguistic’ cannot be maintained. By way of conclusion, I appeal for the opening of a dialogue between neomaterialism and deconstruction, with its focus upon language understood in a much broader sense.
Animal and Sexual Differences: Kelly Oliver’s Continental Bestiary
Authors: Turner Lynn
Published: March 2013

This review article examines Kelly Oliver’s recent book, Animal Lessons: How They Teach Us to Be Human. It has two particular points of focus: Oliver's development of Jacques Derrida’s writing on the ‘animal question’ in light of the expansion of critical animal studies more generally, and Oliver’s specific development of the relations between sexual differences and animal differences.
Neither Body nor Brain: Comparing Preventive Attitudes to Prostate Cancer and Alzheimer’s Disease
Authors: Leibing Annette , Kampf Antje
Published: March 2013

This article compares health promotion attitudes towards prostate cancer and Alzheimer’s disease. Our aim is to demonstrate that these two apparently distinct conditions of the aging body – one affecting the male reproductive system, the other primarily the brain – are addressed in similar fashion in recent public health activities because of a growing emphasis on a ‘cardiovascular logic’. We suggest that this is a form of reductionism, and argue that it leaves us with a dangerous paradox: while re-transcending, at least partially, the conceptual separation of body and brain, it clouds much-needed discussion and research, such as contingent issues of socio-economic and socio-cultural disease disparities.
End-Stage Renal Disease and Critical Limb Ischemia: A Deadly Combination?
Authors: Biancari F. , Arvela E. , Korhonen M. , Söderström M. , Halmesmäki K. , Albäck A. , Lepäntalo M. , Venermo M.
Published: March 2013

Objectives:

This study was planned to evaluate the prognostic impact of end-stage renal disease (ESRD) in patients with critical leg ischemia (CLI) undergoing infrainguinal revascularization.

Materials and Methods:

1425 patients who underwent infrainguinal revascularization for CLI were the subjects of the present analysis. Ninety-five patients had ESRD (eGFR < 15 ml/min/m2), and of them 66 (70%) underwent percutaneous transluminal angioplasty and 29 (30%) underwent bypass surgery.

Results:

ESRD patients had significantly lower overall survival (at 3-year, 27.1% vs. 59.7%, p < 0.0001), leg salvage (at 3-year, 57.7% vs. 83.0%, p<0.0001), and amputation free survival (at 3-year, 16.2% vs. 52.9%, p < 0.0001) than patients with no or less severe renal failure. The difference in survival was even greater between 86 one-to-one propensity matched pairs (at 3-year, 23.1% vs. 67.3%, p < 0.0001). ESRD was an independent predictor of all-cause mortality (RR 2.46, 95%CI 1.85–3.26). Logistic regression showed that age ≥ 75 years was the only independent predictor of 1-year all-cause mortality (OR 4.92, 95%CI 1.32–18.36). Classification and regression tree analysis showed that age ≥ 75 years and, among younger patients, bypass surgery for leg ulcer and gangrene were associated with significantly higher 1-year mortality.

Conclusions:

Lower limb revascularization in patients with CLI and end-stage renal failure is associated with favourable leg salvage. However, these patients have a very poor survival and this may jeopardize any attempt of revascularization. Further studies are needed to identify ESRD patients with acceptable life expectancy and who may benefit from lower limb revascularization.
Budget Impact Analysis of Surgical Treatment for Obesity in Sweden
Authors: Borg S. , Näslund I. , Persson U. , Ödegaard K.
Published: March 2013

Background:

The recent substantial increase in the number of obese surgeries performed in Sweden has raised concerns about the budget impact.

Objective:

Our aim in this paper is to present an assessment of the budgetary impact of different policies for surgical intervention for obese and overweight subjects from a healthcare perspective in Sweden.

Methods:

The model simulates the annual expected treatment costs of obesity related diseases and surgery in patients of different sex, age and Body Mass Index (BMIMI). Costs evaluated are costs of surgery plus the excess treatment costs that an obese patient has over and above the treatment costs of a normal-weight patient. The diagnoses that are included for costs assessment are diabetes and cardiovascular disease since these diagnoses are the principal diagnoses associated with obesity. Four different scenarios over the number of surgical operations performed each year are simulated and compared: (1) no surgical operation, (2) 3 000 surgical operations in persons with BMI > 40, (3) 4000 (BMI > 40), and (4) 5000 (expanded to BMI > 38).

Results:

Comparing Scenario 2 with Scenario 1 results in a net budget impact of on average SEK 121 million per annum or SEK 40 000 per patient. This implies that 55 percent of the cost of surgery, set equal to SEK 90 000 for each patient, has been offset by a reduction in the excess treatment costs of obesity related diseases. Expanding annual surgery from 3000 to 4000 the cost-offset increased to 58%. By expanding annual surgery further from 4000 to 5000 and at the same time expanding the indication for surgery from BMI > 40 to BMI > 38, no cost-offset is obtained.

Conclusion:

A cost-minimization strategy for bariatric surgery in Sweden should not expand indication, but rather increase the number of surgeries within the currently accepted indication.
Obesity Has a Negative Impact on Clinical Outcome after Total Knee Arthroplasty
Authors: Järvenpää J. , Kettunen J. , Soininvaara T. , Miettinen H. , Kröger H.
Published: March 2013

Background and Aims:

Obesity has been linked to the development of osteoarthritis of the knee and since the incidence of obesity is increasing, the need for total knee arthroplasty (TKA) is likely to increase. Conflicting findings have been reported concerning the relationship between obesity and TKA. It has been shown in several studies, that obese patients have poorer clinical results after operation. On the other hand it has also been reported similar results for obese and non-obese patients. The purpose of this study was to analyze clinically and radiologically the results of total knee artrhoplasty in obese patients.

Material and Methods:

The study consisted of 48 patients who had a TKA. The patients were divided in two groups according their body mass index. Patients of BMI over 30 were regarded as obese.

Results:

The obese patients had poorer clinical success at the final follow-up, their WOMAC scores were significantly higher compared to non-obese (pain 20.7 vs. 11.6; p = 0.021, stiffness 26.9 vs. 13.4; p = 0.006, physical function 26.5 vs. 14.4; p = 0.003). Differences were also found in the Knee (KS) and Function (FS) scores and a long-term postoperative ROM and (KS: 83.6 vs. 88.9; p = 0.01, FS: 63.6/76.3; p = 0.051, ROM: 104.6 vs. 109.6; p = 0.016). Non-obese patients reached better percentage improvement in the KSS compared to obese patients (KS change + 194.5% vs. + 59.5%, p = 0.03; FS change + 51.5% vs. + 14.9%, p = 0.19).

Conclusions:

Obesity has a negative impact on the outcome of TKA, assessed by patients' clinical function and satisfaction level.
Accidental Falls Related to Shovelling Snow from Rooftops: Analysis of Injuries in an Extraordinary Epidemic in Southern Finland
Authors: Aulanko M. , Handolin L. , Söderlund T. , Pajarinen J.
Published: March 2013

Background and Aims:

Exceptional amount of snow led to snow removal attempts from the rooftops resulting in a relative unique and extraordinary epidemic of accidental falls in winter of 2010.

Material and Methods:

The injury pattern, hospital care, surgical operations, and the total costs of the primary hospital stay of accidentally fallen patients treated in Helsinki University Hospital trauma unit were analyzed.

Results:

Forty-six patients were admitted to hospital during the study period of three months. Majority of the patients were males (N = 43, 93%) with the average age of 52.9 years. Seven patients were admitted to ICU. The average length of primary hospital stay was 4.7 days with 0% mortality. Total amount of fractures was 65 (63%) of all 97 injuries. The most common injuries were fractures of upper and lower extremity, and spinal column.

Conclusions:

Preventing similar unnecessary epidemics of accidental falls in the future it is important to have professional opinion of the need of snow removal along with understanding of the risk of injury. Wearing appropriate safety equipments, and use professional help when necessary is advisable.
Intravenous Metoprolol versus Biatrial Pacing in the Prevention of Atrial Fibrillation after Coronary Artery Bypass Surgery: A Prospective Randomized Open Trial
Authors: Maaroos M. , Halonen J. , Kiviniemi V. , Hartikainen J. , Hakala T.
Published: March 2013

Background and Aims:

Atrial fibrillation (AF) is the most common arrhythmia after coronary arteryby pass surgery (CABG). Intravenous metoprolol and biatrial pacing have been reported to be effective in AF prophylaxis after cardiac surgery. The purpose of this trial was to compare the efficacy of intravenous metoprolol versus biatrial pacing combined with oral metoprolol in the prevention of AF after CABG.

Methods:

A single-centre prospective randomized open trial of 165 consecutive patients undergoing their first CABG. Patients were randomized to receive either intravenous metoprolol infusion 1–3 mg per hour or biatrial overdrive pacing and oral metoprolol (50–150mg) daily for 72 hours after CABG starting immediately after the surgery. AAI pacing with a pacing rate of 10 beats/minute above the baseline heart rate was used. Patients had continuous ECG-monitoring. The primaryend point was the first episode of AF.

Results:

The incidence of postoperative AF in the intravenous metoprolol and biatrial pacing groups did not differ from each other (14% vs. 18% respecively, p = 0.66). There was no difference in the time of AF on set between the groups (28.2 ± 16.2 h vs. 30.1 ± 21.2 h respectively, p = 0.8). Intravenous metoprolol infusion had to be temporarily interrupted for one hour in eleven patients because of hypotension or bradycardia. One case of bleeding from the left atria related to the pacemaker electrode wire was found.

Conclusion:

We found no difference in the incidence of AF between patients treated with intravenous metoprolol or the combination of biatrial pacing and oral metoprolol.
The Validity of Dependence as a Health Outcome Measure in Alzheimer’s Disease
Authors: Spackman D. Eldon , Kadiyala Srikanth , Neumann Peter J. , Veenstra David L. , Sullivan Sean D.
Published: March 2013

Background:

Relating to Alzheimer’s disease (AD), dependence has been defined as the increased need for assistance due to deterioration in cognition, physical functioning, and behavior. Our objective was to evaluate the association between dependence and measures of functional impairment.

Methods:

Data were compiled by the National Alzheimer’s Coordinating Center. We used multinomial logistic regression to estimate the association between dependence and cognition, physical functioning, and behavior.

Results:

The independent association with dependence was positive. Dependence was most strongly associated with physical functioning. A secondary analysis suggested a strong association of dependence with multiple impairments, as measured by the interaction terms, in more severe patients.

Conclusions:

We find that dependence is simultaneously associated with physical functioning, cognition, and behavior, which support the construct validity of dependence. Dependence might be a more simple measure to explain the multifaceted disease progression of AD and convey the increasing need for care.
Qualitative Research on Dementia in Ethnically Diverse Communities
Authors: Shanley Chris , Leone Desiree , Santalucia Yvonne , Adams Jon , Ferrerosa-Rojas Jorge Enrique , Kourouche Fatima , Gava Silvana , Wu Ying
Published: March 2013

Australia, like other ethnically diverse societies, needs to provide culturally appropriate health care to all its citizens. One way of facilitating this is to ensure that health services research adequately reflects the circumstances and needs of culturally and linguistically diverse (CALD) communities within the population. This article discusses the fieldwork phase of a qualitative research project on dementia caregiving in 4 CALD communities in south west Sydney, Australia. Rather than focusing on the study results—which have been published elsewhere—this article presents and discusses crucial fieldwork issues that arose in the conduct of the project, particularly regarding participant recruitment and facilitation of focus groups. In being transparent about some of the difficulties encountered and how these were managed, we offer suggestions for other researchers wanting to include CALD communities in a meaningful way in their research projects.
The ethics of disseminating dual-use knowledge
Authors: Kuhlau Frida , Höglund Anna T , Eriksson Stefan , Evers Kathinka
Published: March 2013

In 2011, for the first time ever, two scientific journals were asked not to publish research papers in full detail. The research in question was on the H5N1 influenza virus (bird flu), and the concern was that the expected public health benefits of disseminating the findings did not outweigh the potential harm should the knowledge be misused for malicious purposes. This constraint raises important ethical concerns as it collides with scientific freedom and openness. In this article, we argue that constraining the dissemination of dual-use knowledge can in certain cases be justified because, for example: scientists have a responsibility for potentially harmful consequences of their research; the public need not always know of all scientific discoveries; uncertainty about the risks of harm may warrant precaution; and expected benefits do not always outweigh potential harm. However, the constraints in question are not absolute but can be both temporary and partial. We propose three core aspects for an ethics of dual-use dissemination: dual-use awareness, precaution, and acknowledgment of conflicting values. Additionally, to help scientists understand when constraints on dissemination may be justified we suggest three corresponding conditions that prompt scientists to recognize dual-use material or research, consider the potential impact of dual-use knowledge dissemination, and acknowledge and respond to external dissemination concerns.
Video blogging and youth activism in Malaysia
Authors: Lim Joanne B Y
Published: March 2013

The Internet has engendered a ‘democratizing’ effect, especially in highly censored societies. Young activists are increasingly using online sites, such as YouTube, EngageMedia and MySpace as alternative platforms to raise issues that are of importance to the community, but which are taboo in society (e.g., homosexuality, Orang Asli land rights, and ethnic discrimination, among others). The findings from interviews and focus groups conducted with 80 young adults, and a compilation of video blogging platforms/activities popular amongst Malaysians, clearly demonstrate the significant use of videos in advocating human rights, and social and political justice, as well as in challenging existing regulatory and legislative regimes. This article examines how video-sharing websites are fast becoming popular, albeit contested, spaces for critical documentary and experimental works to inform, educate, and encourage discourse among young adults. It then considers the extent to which such ‘viral videos’ embody and/or confront local/national struggles towards social and political change.
Comment: Journeys to the Center of Emotion
Authors: Parkinson Brian
Published: March 2013

Does appraisal co-ordinate emotional responses? Are emotions usually reached via mental representations of relational meaning? This comment considers alternative causal routes in order to assess the centrality of appraisal in the explanation of emotion. Implicit and explicit meaning extraction can certainly help steer the course of emotion-related processes. However, presupposing that appraisals represent the driving force behind all aspects of emotion generation leads to inclusive formulations of appraisal or restrictive formulations of emotion.
Author Reply: The Unbearable Heaviness of Feeling
Authors: Scherer Klaus R. , Ellsworth Phoebe C.
Published: March 2013

The comments by Brosch and Sander, de Sousa, Frijda, Kuppens, and Parkinson admirably complement the four main articles, adding layers of complexity, but perhaps at the expense of theoretical parsimony and stringency. Their suggestions are inspiring and heuristic, but we must not forget that science is about testing concrete predictions.
Isolated Anomalous Origin of the Right Coronary Artery From the Pulmonary Artery in an Asymptomatic 12-Year-Old Girl: Role of MRI in Depicting the Anatomy, Detecting the Ischemic Burden, and Quantifying the Amount of Left-to-Right Shunt
Authors: Shariat Masoud , Grosse-Wortmann Lars , Seed Mike , Yoo Shi-Joon
Published: March 2013

Asymptomatic 12-year-old girl with a heart murmur underwent echocardiogram and suspicious continuous flow was detected in her interventricular septum. She underwent cardiac magnetic resonance (CMR) for further investigation. The CMR images demonstrated anomalous origin of the right coronary artery from the pulmonary artery. Adenosine stress perfusion scan showed an inducible perfusion defect in the right coronary artery and left circumflex artery territories. Flow quantification showed a left-to-right shunt with pulmonary to systemic blood flow ratio (Qp/Qs) of 1.25.
The Paediatric Cardiac Centre for Africa—Proceedings of the March 2012 Symposium
Authors: Kinsley Robin H. , Edwin Frank , Entsua-Mensah Kow
Published: March 2013

The Pediatric Cardiac Centre for Africa (PCCA) was opened by national patron Mr Nelson Mandela on November 7, 2003. In 2008, the Centre’s international pediatric cardiac symposium was introduced as a learning forum for pediatric cardiac surgeons and cardiologists in the continent. The symposium has consistently grown in attendance and attracted distinguished leaders in the field. The 2012 symposium featured Dr. Thomas Spray of Children’s Hospital of Philadelphia, Dr. David Barron of Birmingham Children’s Hospital, and Dr. John Brown of Indiana University School of Medicine as guest speakers. Experience of the Fontan procedure, the small aortic root, hypoplastic left heart syndrome, right ventricular outflow tract reconstruction, transposition of the great arteries, and interrupted aortic arch were the highlights of the symposium. In the “African Corner,” centers in South Africa, Ghana, and Angola presented work done from across the African continent.
Left Atrial Myxoma in a Child
Authors: Sernich Steffan , Chauhan Aman , Singh Dhiraj , Fuchs Hans , Caspi Joseph
Published: March 2013

An eight-year-old child presented with congestive heart failure, blurred vision, and unexplained constitutional symptoms. An echocardiogram demonstrated a giant left atrial mass that obstructed the mitral valve inflow. After excision of the myxoma, the patient had an uneventful recovery.
Coordination Mechanisms Illustrated with Project Management Using the Viable System Model (VSM) as Organizational Framework
Authors: Morales-Arroyo Miguel A. , Chang Yun-ke , Barragán-Ocaña Alejandro , Jiménez Jaime , Sánchez-Guerrero Gabriel
Published: March 2013

Besides authors of classic management who devoted ample works to comprehend coordination, comparatively hardly any other scholar has given a meticulous consideration to the coordination problem in organizations. Coordination is a necessity when two or more entities are interdependent and have to interact to achieve objectives, and essentially, it is the integration of independent endeavors to achieve collective objectives. Individuals and teams need to share their resources, skills, and knowledge to carry out complex tasks and achieve shared goals. In other words, individuals and teams are interdependent. A number of the mechanisms of coordination are profoundly entrenched on social routines and rituals, which complicates the effort to understand its nature. This article conceptualizes mechanism of coordination using the Viable System Model (VSM) as an organizational framework. The Viable System Model also provides a platform that allows to show the coordination mechanisms in the organizational context. While VSM includes coordination processes, it is not very specific, and coordination issues involve the whole organization and cannot be addressed only with feedback and control mechanisms. Consequently, an application that allows extending the usual context of the VSM is discussed. The amalgamation of these concepts is applied to the specific subject, the problem of coordination, having project management as an illustration. Although information and communication technologies (ICTs) have contributed in the praxis to reduce coordination problems, little effort has been undertaken to understand this phenomena. To bridge this knowledge gap, the present article addressed partially this necessity, using project management as an example.
Agenesis of the Ductus Venosus With Extrahepatic Umbilical Vein Connection Into the Right Atrium
Authors: Gore Sharon , Smith Melissa , Nessling Colleen
Published: March 2013

Agenesis of the ductus venosus is a rare anomaly that was first reported in literature within the past decade. Color/Doppler sonography is an important tool for mapping blood flow in determining this aberrant anastomosis. Careful observation of the fetus for signs of congestive heart failure can lead to a positive outcome. In the following case, cardiomegaly was detected and digoxin was introduced, which arrested progression into congestive heart failure.
Contemporary perception of Byzantium in Turkish cinema: the cross-examination of Battal Gazi films with the Battalname
Authors: Bayri Buket Kitapçi
Published: March 2013

During the 1960s and 1970s many Turkish films dealing with Byzantium were produced. The protagonists of these films were usually semi-historical/semi-legendary characters such as Battal Gazi, an eighth/ninth-century Arab frontier warrior. This paper proposes a cross-examination of the Battal Gazi films with the Battalname, a medieval prose work on the deeds of the same frontier warrior, in order to find out what Byzantium represented for the audience of these films in Turkey. This representation is important because the films played a crucial role in shaping the contemporary perception of Byzantium in Turkey.
Epidemiological investigation of two parallel gastroenteritis outbreaks in school settings
Authors: Mellou Kassiani , Sideroglou Theologia , Potamiti-Komi Maria , Kokkinos Petros , Ziros Panos , Georgakopoulou Theano , Vantarakis Apostolos
Published: March 2013

Background

Two parallel gastroenteritis outbreaks occurred in an elementary school and a neighboring kindergarten in Kilkis, Northern Greece in 2012. The aim of the study was the investigation of these two parallel outbreaks as well as their possible source.

Methods

Two retrospective cohort studies were performed to identify the mode and the vehicle of transmission as well as the possible connection between them.

Results

Elementary school and kindergarten populations of 79.9% (119/149) and 51.1% (23/45) respectively, participated in the study. Case definition was satisfied by 65 pupils from the elementary school and 14 from the kindergarten. For elementary school, 53 cases were considered primary cases of the outbreak and were included in the analysis. Based on the results of the multivariate analysis, consumption of tap water was the only statistically significant independent risk factor of gastroenteritis (RR = 2.34, 95% C.I.: 1.55-3.53).; a finding supported by the shape of the epidemic curve which referred to a common point source outbreak with secondary cases. For kindergarten, no statistically significant risk factor was identified, and the epidemic curve supported a person-to-person transmission according univariate analysis. Norovirus GI and GII and human Adenovirus were detected by Real Time PCR in stool samples from seven children of elementary school, but stool samples were not collected by children of the kindergarten.

Conclusions

Even though the etiological agent of the outbreak was not verified, combined epidemiological and laboratory results were in favor of a waterborne viral gastroenteritis outbreak at the elementary school, followed by a person to person spread at the kindergarten.
T1BT* structural study of an anti-plasmodial peptide through NMR and molecular dynamics
Authors: Topchiy Elena , Armstrong Geoffrey S , Boswell Katherine I , Buchner Ginka S , Kubelka Jan , Lehmann Teresa E
Published: March 2013

Background

T1BT* is a peptide construct containing the T1 and B epitopes located in the 5’ minor repeat and the 3’ major repeat of the central repeat region of thePlasmodium falciparumcircumsporozoite protein (CSP), respectively, and the universal T* epitope located in the C-terminus of the same protein. This peptide construct, with B = (NANP)3, has been found to elicit antisporozoite antibodies and gamma-interferon-screening T-cell responses in inbred strains of mice and in outbred nonhuman primates. On the other hand, NMR and CD spectroscopies have identified the peptide B’ = (NPNA)3as the structural unit of the major repeat in the CSP, rather than the more commonly quoted NANP. With the goal of assessing the structural impact of the NPNA cadence on a proven anti-plasmodial peptide, the solution structures of T1BT* and T1B’T* were determined in this work.

Methods

NMR spectroscopy and molecular dynamics calculations were used to determine the solution structures of T1BT* and T1B’T*. These structures were compared to determine the main differences and similarities between them.

Results

Both peptides exhibit radically different structures, with the T1B’T* showing strong helical tendencies. NMR and CD data, in conjunction with molecular modelling, provide additional information about the topologies of T1BT* and T1B’T*. Knowing the peptide structures required to elicit the proper immunogenic response can help in the design of more effective, conformationally defined malaria vaccine candidates. If peptides derived from the CSP are required to have helical structures to interact efficiently with their corresponding antibodies, a vaccine based on the T1B’T* construct should show higher efficiency as a pre-erythrocyte vaccine that would prevent infection of hepatocytes by sporozoites.
Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases
Authors: Qin Jian Zhong , Upadhyay Vivek , Prabhakar Bellur , Maker Ajay V
Published: March 2013

Background

T-cell infiltration in primary colon tumors is associated with improved patient survival. Preliminary data supports a similar association in colorectal liver metastases (CRLM), and we previously identified increased CRLM expression of the immunostimulatory cytokine LIGHT (TNFSF14) to be related to improved patient prognosis. Therefore, mechanisms to augment the T-cell response in CRLM may be a promising treatment modality, however, the tumor immune microenvironment and LIGHT expression in CRLM remains to be characterized.

Methods

Utilizing a syngeneic and immunocompetent model of CRLM, the immune microenvironment was characterized for lymphocyte phenotype, function, and location utilizing flow cytometry, immunoassays, and immunofluorescence microscopy.

Results

CD3+ and CD4+ lymphocytes were decreased, and CD8+ cells were increased in CRLM compared to control liver. When present, greater populations of tumor infiltrating lymphocytes (TIL) were found peritumoral than intratumoral. The TIL expressed significantly higher levels of CD69 and CD107a, but lower levels of LIGHT. Cytokine expression profiles revealed increased levels of the T-helper 1 (Th1) cytokines IFN gamma, IL-12, IL-1b, and IL-8 in CRLM compared to control liver tissue. There was no difference in T-helper 2 (Th2) cytokines between the groups.

Conclusions

Characterization of the tumor microenvironment of CRLM revealed that although a limited number of activated T-cells infiltrate the tumor and initiate an immune response, the number of LIGHT + T cells infiltrating the tumor were very low. Techniques to decrease suppressive influences or augment the cytotoxic T-cell response are needed and may be possible through mechanisms that can increase intratumoral TIL LIGHT expression.
Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
Authors: Wu Celina , Leong Soo Y , Moore Craig S , Cui Qiao Ling , Gris Pavel , Bernier Louis-Philippe , Johnson Trina A , Séguéla Philippe , Kennedy Timothy E , Bar-Or Amit , Antel Jack P
Published: March 2013

Background

FTY720 (fingolimod, Gilenya™) is a daily oral therapy for multiple sclerosis that readily accesses the central nervous system (CNS). FTY720 is a structural analog to the sphingolipid sphingosine-1-phosphate (S1P) and is a cognate ligand for the S1P G-protein coupled receptors (S1PR). Studies in experimental autoimmune encephalomyelitis using mice with conditionally deleted S1P1R from astrocytes indicate that one beneficial effect of FTY720 in this model is via downregulating external receptors, which inhibits responses induced by the natural ligand. Another proposed effect of FTY720 on neuroinflammation is its ability to maintain persistent signaling in cells via internalized S1P1R resulting in functional responses that include suppressing intracellular calcium release. We used human fetal astrocytes to investigate potential dual inhibitory- and function-inducing effects of daily FTY720 on responses relevant to neuroinflammation. For the inhibitory effects, we used signaling and proliferation induced by the natural ligand S1P. For the function-inducing responses, we measured inhibition of intracellular calcium release stimulated by the proinflammatory cytokine, interleukin (IL)-1β.

Methods

Astrocytes derived from human fetal CNS specimens and maintained in dissociated cultures were exposed to 100 nM of the biologically active form of FTY720 over a dosing regimen that ranged from a single exposure (with or without washout after 1 h) to daily exposures up to 5 days. Responses measured include: phosphorylation of extracellular-signal-regulated kinases (pERK1/2) by Western blotting, Ki-67 immunolabeling for cell proliferation, IL-1β-induced calcium release by ratiometric fluorescence, and cytokine/chemokine (IL-6, CXCL10) secretions by ELISA.

Results

We observed that a single addition of FTY720 inhibited subsequent S1PR ligand-induced pERK1/2 signaling for >24 h. Daily FTY720 treatments (3-5 days) maintained this effect together with a loss of proliferative responses to the natural ligand S1P. Repeated FTY720 dosing concurrently maintained a functional cell response as measured by the inhibition of intracellular calcium release when stimulated by the cytokine IL-1β. Recurrent FTY720 treatments did not inhibit serum- or IL-1β-induced pERK1/2. The secretions of IL-6 and CXCL10 in response to IL-1β were unaffected by FTY720 treatment(s).

Conclusion

Our results indicate that daily FTY720 exposures may regulate specific neuroinflammatory responses by desensitizing astrocytes to external S1PR stimuli while sustaining cellular influences that are independent of new surface S1PR activation.
A cross sectional survey of knowledge, attitude and practices related to house flies among dairy farmers in Punjab, Pakistan
Authors: Khan Hafiz Azhar Ali , Akram Waseem , Shad Sarfraz Ali , Razaq Muhammad , Naeem-Ullah Unsar , Zia Khuram
Published: March 2013

Background

House flies are of major public health concerns in areas with poor sanitation and hygienic conditions. Unfortunately, sanitation and hygiene have always been ignored in dairy farms particularly in the developing or low-income countries. Management of these flies mostly depends on the awareness regarding associated hazards and protective measures taken by the people to minimize risks associated with flies. The present study therefore explores the knowledge, attitude and practices taken by dairy farmers in Punjab, Pakistan against house flies.

Methods

The present study was based on a cross sectional self administered survey to a convenience sample of 173 small scale dairy farmers in four localities – Multan, Lahore, Shorkot and Faisalabad – of Pakistan. The relationships between socio-demographics, knowledge and preventive practices were investigated through logistic regression analysis and chi-square test of association.

Results

Considerable number of dairy farmers 71/173 (41.04%) had no idea about the problems associated with house flies. Although 77/173 (44.51%) dairy farmers reported house flies as disease transmitters, only 23 (29.87%) farmers were familiar with diseases and 22 (28.57%) had somewhat idea of the mode of disease transmission. We found a positive association between dairy farmer’s education level and overall knowledge of house flies in multivariate analysis. Farmer’s education level and knowledge of the house flies breeding sites had a positive association with the adoption of house fly prevention practices by the respondents. However, knowledge of the problems associated with house flies and preventive measures had no association with house fly prevention practices.

Conclusion

The present ethnoentomological survey provides information about knowledge, attitude and practices of dairy farmers related to house flies in Punjab, Pakistan. We conclude that the farmers’ education level and knowledge of the breeding sites had a positive association with the adoption of prevention practices against house flies. The study also highlights the need of targeting the lack of knowledge of dairy farmers for the successful management of house flies.
Recovering complete plant root system architectures from soil via X-ray μ-Computed Tomography
Authors: Mairhofer Stefan , Zappala Susan , Tracy Saoirse , Sturrock Craig , Bennett Malcolm John , Mooney Sacha Jon , Pridmore Tony Paul
Published: March 2013

Background

X-ray micro-Computed Tomography (μCT) offers the ability to visualise the three-dimensional structure of plant roots growing in their natural environment – soil. Recovery of root architecture descriptions from X-ray CT data is, however, challenging. The X-ray attenuation values of roots and soil overlap, and the attenuation values of root material vary. Any successful root identification method must both explicitly target root material and be able to adapt to local changes in root properties.

RooTrak meets these requirements by combining the level set method with a visual tracking framework and has been shown to be capable of segmenting a variety of plant roots from soil in X-ray μCT images. The approach provides high quality root descriptions, but tracks root systems top to bottom and so omits upward-growing (plagiotropic) branches.

Results

We present an extension to RooTrak which allows it to extract plagiotropic roots. An additional backward-looking step revisits the previous image, marking possible upward-growing roots. These are then tracked, leading to efficient and more complete recovery of the root system. Results show clear improvement in root extraction, without which key architectural traits would be underestimated.

Conclusions

The visual tracking framework adopted in RooTrak provides the focus and flexibility needed to separate roots from soil in X-ray CT imagery and can be extended to detect plagiotropic roots. The extended software tool produces more complete descriptions of plant root structure and supports more accurate computation of architectural traits.
Sex-differences in reasons for non-participation at recruitment: Geelong Osteoporosis Study
Authors: Markanday Shikha , Brennan Sharon L , Gould Haslinda , Pasco Julie A
Published: March 2013

Background

Understanding reasons for non-participation in health studies can help guide recruitment strategies and inform researchers about potential sources of bias in their study sample. Whilst there is a paucity of literature regarding this issue, it remains highly plausible that men and women may have varied reasons for declining an invitation to participate in research. We aimed to investigate sex-differences in the reasons for non-participation at baseline of the Geelong Osteoporosis Study (GOS).

Methods

The GOS, a prospective cohort study, randomly recruited men and women aged 20 years and over from a region in south-eastern Australia using Commonwealth electoral rolls (2001–06 and 1993–97, respectively). Reasons for non-participation (n=1,200) were documented during the two recruitment periods. We used the Pearson’s chi squared test to explore differences in the reasons for non-participation between men and women.

Results

Non-participation in the male cohort was greater than in the female cohort (32.9% vs. 22.9%; p<0.001). Overall, there were sex-differences in the reasons provided for non-participation (p<0.001); apparent differences related to time constraints (men 26.3% vs. women 10.4%), frailty/inability to cope with or understand the study (men 18.7% vs. women 30.6%), and reluctance over medical testing (men 1.1% vs women 9.9%). No sex-differences were observed for non-participation related to personal reason/disinterest, and language- or travel-related reasons.

Conclusions

Improving participation rates in epidemiological studies may require different recruitment strategies for men and women in order to address sex-specific concerns about participating in research.
Helmholtz tomography of ambient noise surface wave data to estimate Scholte wave phase velocity at Valhall Life of the Field
Authors: Mordret Aurélien , Shapiro Nikolaï M. , Singh Satish S. , Roux Philippe , Barkved Olav I.
Published: March 2013

We applied the Helmholtz tomography technique to 6.5 hours of continuous seismic noise record data set of the Valhall Life of Field network. This network, that has 2320 receivers, allows us to perform a multifrequency, high-resolution, ambient-noise Scholte wave phase velocity tomography at Valhall. First, we computed crosscorrelations between all possible pairs of receivers to convert every station into a virtual source recorded by all other receivers. Our next step was to measure phase traveltimes and spectral amplitudes at different periods from crosscorrelations between stations separated by distances between two and six wavelengths. This is done in a straightforward fashion in the Fourier domain. Then, we interpolated these measurements onto a regular grid and computed local gradients of traveltimes and local Laplacians of the amplitude to infer local phase velocities using a frequency dependent Eikonal equation. This procedure was repeated for all 2320 virtual sources and final phase velocities were estimated as statistical average from all these measurements at each grid points. The resulting phase velocities for periods between 0.65 and 1.6 s demonstrate a significant dispersion with an increase of the phase velocities at longer periods. Their lateral distribution is found in very good agreement with previous ambient noise tomography done at Valhall as well as with a full waveform inversion P-wave model computed from an active seismic data set. We put effort into assessing the spatial resolution of our tomography with checkerboard tests, and we discuss the influence of the interpolation methods on the quality of our final models.