bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful Crowdfunding in Indonesia Based on Financial Projection and Investor Attraction: Empirical Study on Micro, Small and Medium Enterprises (MSMEs) on the Bizhare Platform
Authors: Permatasari Anggrian Faulina , Ulum Ihyaul , Arisanti Ike
Published: April 2022

Research aims: This study aims to examine the effects of investor attraction and financial projection on successful crowdfunding. Design/Methodology/Approach: A purposive sampling method was used by the researchers. The research sample consisted of 48 projects from the Bizhare platform from 2018 to 2021, with the following criteria: providing data that could be used as an indicator for measuring each variable. In testing the hypotheses, multiple linear regression analysis was employed with a principal component analysis model.Research Findings: The financial projection positively affected successful crowdfunding, while investor attraction negatively affected successful crowdfunding in Indonesia.Theoretical contribution/Originality: This study’s results are an additional discussion toward theory and literature related to crowdfunding.Practitioner/Policy implication: Disclosure of prospectus plays an essential role in preventing information asymmetry that may arise between managers and investors by providing knowledge to external investors. This study is needed to accelerate economic recovery due to the pandemic, which especially causes new projects to be trapped, saves MSMEs from limited capital, and improves business development.Research limitation/Implication: This research only used one platform as an object because not all crowdfunding platforms could be accessed and provided the information needed for research.
Effectiveness of CAPM Model for Funds Based on Margin Trading in Chinese Market under the COVID-19 Pandemic
Authors: Zhang Mingke
Published: April 2022

The applicability of CAPM model in China was studied under the situation that the global economy was greatly affected.  The results show that the stock exchange market in China is less affected by the epidemic. Still in China's securities market, the linear impact of systematic risk on the return on assets is not significant, while the non-systematic risk has a relatively significant linear impact on the return on assets. The CAPM model is not fully applicable in China's securities market. Except that the financial market in China is not sound enough, the reason for the inapplicability of the model would be the drawbacks of the model itself as the model is too sophisticated in its assumptions and there are many factors not considered, and the research direction of improving the model are summarised as pay attention to 6 types of asset pricing anomalies represented by value anomalies, and provide explanations for the causes of these pricing anomalies.
Analysis on the Reconstruction of Primary School Mathematics
Class Based on the Theory of “Thinking Visualization”
Authors: Zhao Zixi
Published: April 2022

With the continuous advancement of the new curriculum reform, the cultivation of primary and secondary school
students’ thinking ability has gradually become the focus of education, and the strength of thinking ability will have a profound
impact on students’ problem analysis and judgment ability. Thinking visualization theory provides important guidance for the
cultivation and orderly development of students’ thinking ability. The application of thinking visualization theory in primary
school mathematics teaching can realize the effective combination of graphics and text, and then present mathematics knowledge
and conceptual content to students concretely and vividly, and help students effectively sort out knowledge, To achieve high
quality and efficient learning, reduce the primary school students in the process of mathematics problems and difficulties. This
research focuses on the reconstruction of primary school mathematics classroom under the theory of “thinking visualization”，and
provides ideas and methods from multiple perspectives.
A Homed-based PLC for Improving Parents’ Leadership Under the “Double Reduction” in China
Authors: Li Xiaomin , Mo Minying , Duan Ran
Published: April 2022

Recently,china government conducts a new education reform policy-Double Reduction policy, including the reduce
the student homework burden and shadow education burden,which draw the heated discussion to the family education. Though
recently researchers began to discuss the relationship between parent leadership and children study performance, they mainly
considered the leadership as antecedents of parent involvement, while few considered parenting mode. This paper aims to find out
a home-based PLC mode for impoving mutil-parents leadership under this policy.
Research on Confucian Cultural Tourism Development under the Background of Cultural and Tourism Integration
Authors: Kan Yuli
Published: April 2022

Qufu,as the birthplace of Confucius,is the origin of Confucian culture and has rich cultural tourism resources.

However,the development of Qufu’s tourism industry is still limited to the sightseeing tour,and its unique cultural advantages

have not been substantiated and three-dimensionally explored.This article sorts out the problems in the development of Confucius

cultural tourism,and discusses the materialization of intangible cultural heritage.The theme product development,festival activity

development and other tourism development models promote the protection and inheritance of Confucius culture and improve the

quality of Qufu cultural tourism products.
Challenges and Coping Strategies of Radiology Doctors During COVID-19 Era, Lahore, Pakistan
Authors: Shahid Ayesha , Arif Khadija , Sarfraz Saulat , Javed Amna , Ikram Muhammad , Ihsan Ammara
Published: April 2022

Objective: To evaluate the challenges and coping strategies by Radiology Doctors during the COVID-19 Era. Materials and Methods: It is a mixed-method cross-sectional study done over one month in Radiology Department, Shaikh Zayed Hospital, Lahore, Pakistan with a convenient sampling technique. Results: 80% of the radiologists faced challenges during the pandemic. Age, gender, marital status, monthly income, residents, and years of residency showed significant associations with challenges faced by doctors in the radiology department during the COVID-19 pandemic. Many challenges in terms of management, psychological aspects, training education, and research work were faced by the radiologists but they coped with them heroically. Conclusion: COVID-19 posed a spectrum of unforeseen challenges to the radiologists of Shaikh Zayed Hospital, Lahore. Challenges related to management, psychological aspects for doctors, research work and training education were all tackled by the senior and junior doctors by using various coping strategies.
Periodontal Management of Palatogingival Groove – Case Report
Authors: Kshirsagar Jaishree Tukaram , S. Kokhila , Albert Vidya
Published: April 2022

Periodontal and endodontic infections are interrelated and most common during routine dental practice. Palatogingival groove, a morphological anomaly usually reported on the palatal aspect of maxillary incisors, cause periodontal attachment loss and alveolar bone destruction and finally tooth loss. Unknown etiology was reported for the developmental defect, develops in to pathological condition only when the there is a discontinuity in the epithelial attachment. Early diagnosis and proper selection of therapeutic modalities helps in preservation of involved tooth. Milder cases were treated by saucerization, odontoplasty and strict oral hygiene maintenance protocol. Moderate case was treated by open flap debridement, regenerative applications such as bone graft and membrane placement. PGG restored using various restorative material and seal the morphology. Clinical diagnosis become unnoticed in most cases, hence proper diagnosis and therapeutic interventions are of prime importance in PGG management.
An In-vivo Study to Evaluate the Onset of Relief from Ibuprofen, Placebo and Occlusal Splint in Patients with Acute Myalgia in Muscles Related to Temporomandibular Joint: A Comparative Pilot Study
Authors: Gupta Deeksha , Nirmal Narendra J. , Arora Himanshu , Mehta Sonal , S. Jishnu , Raj Ruchi
Published: April 2022

Purpose: The treatment priority in management of Temporomandibular Joint (TMJ) pain is directed towards the causative factor along with symptomatic treatment. In this process many times psychological aspect is overlooked. Hence with this pilot study, importance of psychological aspect of Temporomandibular Joint Disorder (TMD) is emphasised. Methods and Material: 15 patients suffering from pain in TMD region who qualify under myalgia pain in DC/TMD Axis I category were selected. Patients were divided into 3 groups; Ibuprofen, placebo and occlusal splint with 5 patients in each group. Pain assessment was done at the first visit, 7th day visit and 14th day visit using a VAS scale. Statistical Analysis Used: Friedman Test was applied to determine overall relief from pain in the three groups. Wilcoxon sign rank test evaluated pain relief between each time interval. Kruskal Wallis Test compared different groups for relief from pain at each time interval. Key Finding: Wilcoxon sign rank test showed a significant pain relief in all three groups from I day to I follow up day and I day to II follow up day. However Pain relief from I follow up to II follow up day was significant only in placebo group. Conclusions: Management of TMD myalgia requires a comprehensive understanding of physical and psychological aspect. This will aid us in formulating a treatment plan comprising pharmacotherapy, placebo or physical therapy or combination of any of these.
Comparative Evaluation of Platelet Rich Fibrin Membrane vs. Collagen Membrane in Combination with Hydroxy-Apatite (HA) for the Treatment of Mandibular Molar Furcation Defects – A Randomized Clinical Control Trial
Authors: Jain Saurabh , Kapoor Anjali , Vijay Sharmistha , Gupta Shikha , Soangra Rajeev , Saini Neha
Published: April 2022

Aim: A clinical trial to compare the relative efficacy of hydroxyapatite in combination with either PRF (Platelet rich fibrin) or collagen membrane in treatment of grade II furcation defects of mandibular molars. Methodology: The sample consisted of 35 Grade II mandibular molar furcation defects planed for open flap debridement (OFD) (Group 1, n=12), Platelet-rich fibrin membrane + Hydroxyapatite (HA) with OFD (Group 2, n=12), and Collagen membrane (CM) + HA with OFD (Group 3, n=11). These were recorded at baseline and 9 months postoperatively for plaque index (PI), gingival index (GI), probing depth (PPD), relative vertical and relative horizontal clinical attachment levels (RVCAL and RHCAL), and intrabony defect depth (IBD). Results: PI and GI scores decreased significantly in all three groups at 9 months postoperatively as compared to baseline scores. After 9 months of follow up visits mean PD reduction was greater in Group 2 (3.66 ± 0.98 mm) and Group 3 (3.45 ± 1.5 mm) than Group 1 (2.08 ± 0.90 mm), and mean RVCAL and RHCAL gain were greater in Group 2 (3.25 ± 0.75 mm and 3.92 ± 0.29 mm, respectively) and Group 3 (3.09 ± 0.70 mm and 3.89 ± 0.54 mm) compared with Group 1 (1.33 ± 0.77 mm and 2.25 ± 0.62 mm). A significant reduction in IBD depth was found in Groups 2 (2.16*0.38 mm) and 3 (1.58*0.35 mm) than in Group 1 (0.70*0.15 mm). The differences in PI, GI, PPD, RVCAL, and RHCAL between Groups 2 and 3 at baseline and 9 months were not statistically significant. There was a statistically significant difference in the depth reduction of IBD between Groups 2 and 3 at nine months. Conclusion: Within the scope of this study, it can be stated that the use of HA in conjunction with PRF or CM in the treatment of grade II mandibular furcation abnormalities resulted in a considerable reduction in GI PI, PPD, RVCAL, RHCAL, and IBD depth on follow up visit at 9 months after surgery. However, the combination of HA with PRF membrane exhibited significant improvement in radiographic parameters in comparison to the combination of HA with Collagen membrane.
Antiproliferative effects of isoalantolactone in human liver cancer cells are mediated through caspase-dependent apoptosis, ROS generation, suppression of cell migration and invasion and targeting Ras/Raf/MEK signalling pathway
Authors: Wu Zhi-cong , Hui Xin-geng , Huo Lin , Sun Dong-xiao , Peng Wen , Zhang Ying , Li Xiao-bing , Ma Tian , Li Wen-hui , Liang Jing , Sun Zhi-qiang
Published: April 2022

The main objective of this study was to evaluate the in vitro antiproliferative effects of isoalantolactone against liver cancer cells (Hep-G2) and also monitor its mechanism of action. The MTT assay was involved in proliferation assessments and phase contrast microscopy was used to check cellular morphology. Acridine orange/ethidium bromide staining along with western blotting was used to evaluate proapoptotic effects of isoalantolactone. DCFH-DA staining was used in ROS measurements. Transwell migration and invasion assay were executed to check the effects of isoalantolactone on migration and invasion of Hep-G2 cells. Western blotting was used to check the expressions of Ras/Raf/MEK signalling pathway in Hep-G2 cells. Results demonstrated that isoalantolactone significantly (*p<0.05 and **p<0.01) inhibited the proliferation of Hep-G2 cells in a concentration and time-reliant fashion. The IC50 value of the tested isoalantolactone molecule was found to be 71.2 µM and 53.4 µM at 12 h and 24 h time intervals respectively. Moreover, the antiproliferative effects of isoalantolactone were mediated through induction of caspase-dependent apoptosis and oxidative stress (ROS mediated). The proapoptotic effects of isoalantolactone were evident from morphological assessments and improved expressions of caspase-3, -8, and -9 and Bax while antiapoptotic Bcl-2 was reduced significantly. Additionally, antiproliferative and proapoptotic effects of isoalantolactone were found to be a consequence of blocking of Ras/Raf/MEK signalling in Hep-G2 cells. Furthermore, isoalantolactone significantly (*p<0.05) targeted the migration and invasion of Hep-G2 cells. In conclusion, these results validated that isoalantolactone shows strong antiproliferative activity against Hep-G2 liver cancer cells. Therefore, it could prove as a leading candidate in liver cancer research, drug discovery and design.
Evaluation of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) and sLOX-1/oxidized LDL ratio as novel biomarkers of acute coronary syndrome
Authors: Hussein Reham A. , Abdul- Rasheed Omar F. , Basheer Mouayed
Published: April 2022

The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved in the pathophysiology of atherosclerosis and acute coronary syndromes (ACS). In patients with acute coronary syndrome, circulating soluble LOX-1 (sLOX-1) levels are dramatically elevated. This study aimed to assess sLOX-1 levels in acute coronary syndromes and determine the ratio of sLOX-1 and oxidative LDL in cases of myocardial infarction and unstable angina pectoris and the ROC curve for this ratio sLOX-1. A case-control study was conducted at the department of chemistry and biochemistry, college of medicine, Al- Nahrain University, Baghdad, Iraq, from September 2020 to January 2021. In a total of 90 subjects (30 patients with myocardial infarction within the first six hours of chest pains, 30 patients with unstable angina pectoris, and 30 healthy donors). The ELISA technique measured concentrations of sLOX-1 and oxidized LDL. In addition, Troponin and highly sensitive C reactive protein were measured by the same technique (Fluorescence immune assay), and lipid profile was measured using the Spectrophotometer technique. The median level of sLOX-1 in MI group was 476.17 pg/ml (90.88–675.4 pg/ml) which was significantly higher than that of UA patients (median=289.1 pg/ml [62.74-585.43 pg/ml]) and controls (median=144.52 pg/ml [79.17-283.83 pg/ml]) with highly significant differences and the median sLOX-1/OX-LDL ratio in patients with MI was 64.6 (range 15.17-100.15) which was significantly higher than either patients with UA (median=37.6 [7.06-88.65]) or controls (median=25.29 [12.7-43.04]). There were elevated levels of sLOX-1 in acute coronary syndromes. The sLOX-1/oxidized LDL ratio also strongly indicated the diagnosis and a discriminatory force on the ROC curve for myocardial infarction.
​Reinforcement of Women through Self Help Group (SHG): A Case Study of Warangal District, Andhra Pradesh
Authors: Niwas Ram , Sharma Charu , Sharma Sunil Kumar
Published: April 2022

The objective of this case study is to see the impact of SHG, Village Organization and Mandal Samakhaya formation on the their members which is strongly promoting women’s empowerment in the Andhra Pradesh. For said purpose Information’s were collected through Personally interaction with the members of SHG in Village Organization Meeting during Five days exposer visit (25 Nov to 30 Nov, 2013) which was supervised by National Institute of Rural Development and Panchayati Raj (NIRD and PR), Hyderabad (A.P.) Staff members on the recommendation of Deendayal Upadhyaya State Institute of Rural Development, Lucknow (U.P.). Result can be concluded in terms of the SHG formation and their rules are playing important role for the women empowerment and income generation in Warangal district.
Participation in Physical Activity Contributes to Adolescents' Physical Activity Attitudes and Quality of Life Related to Their Body Image
Authors: Akil Mustafa
Published: April 2022

Physical activity (PA) habit decreases and Body Image (BI) becomes important during adolescence. This paper focuses on determining two things: whether the level of participation in PA contributes to adolescents’ PA attitudes and their quality of life-related body image and to examine whether there is a difference. The study utilized the cross-sectional design. 1281 individuals in the middle adolescence period participated in the study. Participants were between 15 and 17 years. International Physical Activity Questionnaire Short Form (IPAQ-SF), Cognitive Behavioral Physical Activity Questionnaire (CBPAQ), and Body Image Quality of Life Inventory (BIQLI) were used as data collection tools. According to the study findings, there were significant differences in the BIQLI total, interaction with the opposite sex, and influence behavior/attitude between those who engaged in regular or irregular PA and those who did not engage in PA at all. Difference in the effect on self-efficacy and daily life sub-dimension was found between those who engaged in regular PA and those who did not. Outcome expectation and self-regulation items of those who engaged in PA were higher than for those who did not. Since adolescents are expected to engage in regular or irregular PA, personal barriers in front of them must be removed. It is therefore important to support their attitudes, which positively affects their PA, because participation in PA contributes positively to their PA and BI-related quality of life.
La libre circulación tras (¿?) la Covid-19. Retos en materia de restricciones, nuevos modelos familiares y digitalización
Authors: Miranda Boto José María
Published: April 2022

La libre circulación de trabajadores, en más de medio siglo de existencia, se ha enfrentado a diversos obstáculos. Pocos han tenido las dimensiones de la pandemia de la Covid-19, que puso de manifiesto dificultades insospechadas. El presente trabajo pretende analizar las soluciones a esas dificultades, tanto desde el terreno de las restricciones derivadas de herramientas como el Pasaporte Covid como de las posibles garantías de futuro. Los certificados de vacunación, derivados de una normativa que busca asegurar la libre circulación, presentan una doble naturaleza como restricción que merece ser analizada. Por otra parte, la consolidación de la idea de las ocupaciones críticas está llamada a tener una gran importancia, pero exige un último esfuerzo en su puesta en práctica efectiva. Junto a estas cuestiones, el trabajo estudia también la adaptación de la normativa existente a los nuevos modelos de familia, incluyendo consideraciones sobre la jurisprudencia del Tribunal de Justicia y los matrimonios del mismo sexo y su choque con determinadas legislaciones. Son objeto de atención, además, de forma teórica, los posibles problemas derivados de matrimonios a través de formas no reconocidas. Por último, se plantean algunas posibilidades a propósito del trabajo en plataformas y del teletrabajo digital.
ConVRgence (VRIC) Virtual Reality International Conference Proceedings
Authors: Richir Simon
Published: April 2022

This document presents the proceedings of the VRIC - ConVRgence conference held on April 12-14, 2022. The conference was held in the Laval Virtual World. We would like to thank the authors who submitted their research works, as well as the reviewers for their contributions.
Simon Richir, Arts et Métiers Institute of Technology, Scientific Director of Laval Virtual
The effectiveness of the distance learning system of an educational institution
Authors: Preobrazhensky Y. P.
Published: April 2022

The article discusses the features a distance learning system (LMS) organization of an educational institution, reflects modern approaches to the implementation of management decisions in educational organizations. Among the main advantages of using the LMS are free access to the training course, the adaptability and flexibility of the educational trajectory, the relevance of training, minimization of costs, simplified access to training materials for people with disabilities, synchronous and asynchronous educational process, depending on the current needs of the educational institution. The relevance of the information tools used and the reduction of various kinds of costs (labor resources, time costs) during their implementation are emphasized. Particular attention is paid to issues of a financial nature, including the rationale for choosing a platform for the implementation of LMS based on commercial, free access or a system developed by its own resources. It is noted that the use of the SCORM, Tin Can and similar formats in the development of their own LMS may fade into the background if an educational institution has its own standards for electronic documents of open formats, such as XML. The need to build a quality control system for the implementation of the educational process in the development of your own LMS is shown. The distinguishing features are the possibility of generating multi-level reports and the formation of learning statistics, as well as the possibility of analytics, depending on the changing needs of an educational institution for monitoring and managing the educational process in a remote mode. It is noted that individually developed LMS, in contrast to open and commercial ones, have the ability to add their modules for the analysis of statistics. The article provides data on the effectiveness of using this tool for all target groups (faculty, students, administrative staff, legal representatives of students) and their impact on the overall organization of the management process in the system of higher and secondary vocational education.
DINÁMICA DEL GLIFOSATO EN EL SUELO Y SUS EFECTOS EN LA MICROBIOTA
Authors:   Universidad Autónoma Metropolitana- Xochimilco. Departamento de Producción Agrícola y Animal. Calzada del Hueso 1100, Col. Villa Quietud, 04960, México, González Ortega Emmanuel , Fuentes Ponce Mariela H. ,   Universidad Autónoma Metropolitana- Xochimilco. Departamento de Producción Agrícola y Animal. Calzada del Hueso 1100, Col. Villa Quietud, 04960, México.
Published: April 2022

El glifosato, que es el herbicida más usado mundialmente, interfiere en la síntesis de aminoácidos aromáticos esenciales, eliminando las plantas sensibles. Su uso aumentó al introducirse cultivos genéticamente modificados tolerantes al herbicida, y al usarse como desecante de cultivos anuales. El glifosato, clasificado como probable cancerígeno, ha generado efectos adversos en la salud humana y ha ejercido presión de selección generando plantas resistentes al herbicida. Las formulaciones comerciales contienen moléculas como polioxietilenaminas y metales pesados. En México no hay datos sobre la cantidad de glifosato empleado en la agricultura, pero se detectó en suelo, ríos y mares, así como en personas directa o indirectamente expuestas al herbicida. El glifosato y su metabolito ácido aminometilfosfónico (AMPA) tienen baja movilidad en los suelos por su alta capacidad de adsorción; su movilización y descomposición dependen de la estructura del suelo, cantidad y calidad de la materia orgánica, temperatura, pH, y tipo de arcilla, entre otros. La relación entre la microbiota edáfica y el glifosato es biunívoca: algunas especies bacterianas lo usan como fuente de C y P, degradando al herbicida, y otras sufren alteraciones adaptativas ante la exposición al glifosato. El herbicida altera la capacidad de micorrización de los hongos arbusculares y desregula la expresión de genes implicados en procesos como el metabolismo de los aminoácidos o vías relacionadas con detoxificación. Asimismo, afecta a diversas especies de lombrices del suelo, disminuyendo su capacidad de reciclar materia orgánica. Debe promoverse la investigación orientada a la producción agrícola sin el uso de agroquímicos altamente tóxicos y persistentes.
XPS Study Calcining Mixtures of Brucite with Titania
Authors: Sánchez-Zambrano Karla Sofía , Hernández-Reséndiz Marina , Gómez-Rodríguez Cristian , García Quiñonez Linda Viviana , Aguilar-Martínez Josué Almicar , Rodríguez-Castellanos Eden Amaral , Verdeja Luis Felipe , Fernández-González Daniel , Castillo-Rodríguez Guadalupe Alan
Published: April 2022

In this paper, the phases in the Mg-Ti-O system using the 1:1 formulation of MgO:TiO2 mixing synthetic brucite of Mexican origin with TiO2 microparticles of high purity and with a heat treatment at 1100°C for 1 h were studied. The raw materials and formulation by XPS and DRX techniques were characterized. The results demonstrate the presence of different oxidation states in titania and the formation of different oxides in the Mg-Ti-O system when mixed and calcined at 1100°C; additionally, the formation of vacancies in the crystal lattice during the transformation from hexagonal brucite to magnesia with a cubic structure centered on the faces is estimated. With the results, its thermal behavior is warned based on the MgO-TiO2 phase diagram.
The Association between Self-Reported Daily Energy Intake from Carbohydrates with Insulin Resistance in Healthy Weight Nor-Mal-Weight Individuals
Authors: Al-Rashed Fatema , Sindhu Sardar , Madhoun Ashraf Al , Alzaqqah Fatemah , Akter Nadeem , Al-Mulla Fahd , Ahmad Rasheed
Published: April 2022

Abstract: Carbohydrates form the major source of energy in Asian diets. A lower carbohydrate diet became the recommended golden standard for healthy lifestyle. However, the effects of low-carbohydrates diet on health in apparently healthy individuals have been poorly studied, especially in relation to insulin resistance syndrome (IRS). A total of 120 healthy weight participants with no previous history of a major medical condition and an average BMI of ≤ 25kg/m2 were recruited. Self-reported dietary intake and objective physical activity by accelerometry were tracked for seven days. Participants were divided into three categories according to their dietary intake of carbohydrates. Blood samples were collected for metabolic markers analysis. HOMA of insulin resistance (HOMA-IR), β-cell function (HOMA-B) and C-peptide were used to evaluate glucose homeostasis. The consumption of low carbohydrates (less than 45% of total energy) significantly correlated with higher HOMA-IR, Lower HOMA-β % compared to moderate carbohydrate intake (between 45% to 65%). However, only the HOMA-β % was significantly influenced by carbohydrates intake. Moreover, low carbohydrates intake was significantly associated with elevated C-peptide secretion. The substitution of carbohydrates with other macronutrients, such as fat and proteins in the Atkins/ketogenic diet, resulted in a pronounced induction of IRS-related inflammatory markers; FGF2, IP-10, IL-6, IL-17A, MDC and reduction of IL-13. Overall, the presented data highlight, for the first time, that low carbohydrate intake results in significant glucose homeostasis imbalance that may be driven by a heightened state of inflammatory response.
Fatores relacionados à qualidade de vida de idosos de uma comunidade quilombola da Paraíba
Authors: Batista Correia Iasmim , Alves de Olinda Ricardo , Nobre de Menezes Tarciana
Published: April 2022

O artigo apresenta fatores relacionados à qualidade de vida de idosos de uma comunidade quilombola da Paraíba. Trata-se de estudo transversal, realizado com idosos de ambos os sexos, residentes na comunidade quilombola Caiana dos Crioulos, Alagoa Grande/PB, Brasil, cadastrados no e-SUS como residentes dessa comunidade. A variável dependente é a qualidade de vida relacionada à saúde (QVRS) e as independentes são perfil socioeconômico-demográfico, situação de saúde, estado nutricional e força muscular. Foi realizada correlação de Spearman, regressão linear simples e múltipla (IC95%; p<0,05) para verificar a relação entre as variáveis. Foram avaliados 45 idosos (66,6% mulheres), com média etária de 71,3 anos, dos quais 42,2% apresentaram QVRS ruim no componente físico e 44,4% no componente mental. Os sintomas indicativos de depressão, o número de doenças crônicas não transmissíveis (DCNT) e o teste sentar e levantar explicaram, conjuntamente, 37% (R²=0,379, p<0,05) da QVRS ruim. Sugere-se a assistência integral e prioritária pelos serviços de saúde pública, visando controlar e reduzir a ocorrência de doenças físicas e psicológicas e manter a força muscular.
Time use and food insecurity in female-headed households in Brazil
Authors: Braga Cicero , Costa Lorena
Published: April 2022

In Brazil, female-headed households disproportionately experience food insecurity. However, empirical and theoretical evidence shows that women are better than men at allocating intra-household resources to achieve well-being. In observation of this paradox, the present work studies the process of poverty feminization, and presents a collective decision model to understand the vulnerability situation of women. Specifically, we aimed to observe how time use and food insecurity correlate. We estimated an ordered probit model with Brazilian National Household Sample Survey data. Our studies found that women manage a double burden of both paid and unpaid jobs. This increases their risk of food insecurity, confirming the importance of time allocation in household well-being. Conversely, this effect is inverted when household tasks are shared with another member, specifically the spouse. Single mother households still face several challenges, which require specific policies and studies.
Reliability and Repeatability of the China-Japan Friendship Hospital Typing Classification for Nontraumatic Osteonecrosis of the Femoral Head
Authors: Liu Li-hua , Li Zi-rong , Sun Wei , Wang Yun-ting , Gao Fu-qiang
Published: April 2022

Background:

The purpose of this study was to analyze the interobserver reliability and intraobserver repeatability of the China-Japan Friendship Hospital (CJFH) typing classification system for nontraumatic osteonecrosis of the femoral head (ONFH).

Methods:

Image data of 50 hips were randomly selected in 289 patients (433 hips) with ONFH who underwent treatment in the China-Japan Friendship Hospital from 2012 to 2016. Bilateral hip plain radiography, magnetic resonance imaging (MRI), or computerized tomography (CT) were performed in all hips. The assessments were performed by 8 new residents independently, and the repeatability was assessed at 4-week intervals. Evaluation indicators included the size, location, and extent of necrotic lesions. Kappa values were used to determine the reliability and repeatability.

Results:

According to the CJFH classification system, 2,800 evaluations were performed with an average interobserver Kappa value of 0.711, and 400 assessments were performed with an average intraobserver Kappa value of 0.748. Reliability analysis indicated a higher reliability and repeatability of this classification system. Critical factors affecting the consistency included the accurate selection of the median coronal plane and definitive tri-pillar division of the femoral head.

Conclusion:

The CJFH classification system is a simple and direct evaluation model for ONFH with substantial inter- and intraobserver reliability.
Outcomes following Total Hip Arthroplasty for Femoral Head Osteonecrosis in Patients with History of Solid Organ Transplant
Authors: Quinlan Nicole D. , Chen Dennis Q. , Werner Brian C. , Cui Quanjun
Published: April 2022

Background:

Osteonecrosis of the femoral head (ONFH) is a potentially debilitating condition, often requiring total hip arthroplasty (THA). Patients with solid organ transplant (SOT) are at increased risk of postoperative complications after THA for osteoarthritis. The objective of the present study is to evaluate SOT as a potential risk factor for complication after THA for ONFH.

Methods:

This is a retrospective study that identified patients with SOT who underwent THA for ONFH from 2005 to 2014 in a national insurance database and compared them to 5:1 matched controls without transplant. Subgroup analyses of patients with renal transplant (RT) and those with non-RT were also analyzed. A logistic regression analysis was used to compare rates of mortality, hospital readmission, emergency room (ER) visits, infection, revision, and dislocation while controlling for confounders. Differences in hospital charges, reimbursement, and length of stay (LOS) were also compared.

Results:

996 patients with SOT who underwent THA were identified and compared to 4,980 controls. SOT patients experienced no increased risk of early postoperative complications compared to controls. Solid organ transplant was associated with higher resource utilization and LOS. Renal transplant patients were found to have significantly higher risk of hospital readmission at 30 days (odds ratio [OR] 1.77; p = 0.001) and 90 days (OR 1.62; p < 0.001) and hospital LOS (p < 0.001), but had lower risk of infection (OR 0.65; p = 0.030). Non-RT patients had higher rate of ER visits at 30 days (OR 2.26; p = 0.004) but lower rates of all-cause revision (OR 0.22; p = 0.043).

Conclusions:

Patients with history of SOT undergoing THA for ONFH utilize more hospital resources with longer LOS and greater risk of readmission but are not necessarily at an increased risk of early postoperative complications.
Decreased Ankyrin Expression Is Associated with Repressed eNOS Signaling, Cell Proliferation, and Osteogenic Differentiation in Osteonecrosis of the Femoral Head
Authors: Lin Rio L.C. , Sung Pei-Hsun , Wu Chen-Ta , Tu Yuan-Kun , Lu Yu-Der , Yip Hon-Kan , Lee Mel S.
Published: April 2022

Background:

Reduced nitric oxide synthase (NOS) activity and decreased reparative potentials in stem cells may be involved in the pathogenesis of osteonecrosis of the femoral head (ONFH), but the underlying mechanism is not clear. Ankyrin, a cytoskeletal protein, can promote NOS expression and many cellular functions when it interacts with the CD44 receptors on the stem cells. This study investigated whether ankyrin is involved in the pathogenesis of ONFH.

Materials and Methods:

Bone marrow stem cells (BMSCs) from ONFH patients were compared with cells from patients with proximal femoral fracture and BMSC cell lines (PT-2501, Lonza, NC, USA). Differences in the expression levels and downstream signal pathway of ankyrin-Akt-eNOS in BMSCs were studied between ONFH and control. The involvement of ankyrin in the signal cascade, cell proliferation, and differentiation were further investigated by silencing ankyrin using small interfering (si)RNA.

Results:

We found the basal mRNA levels of ankyrin and CD44 in BMSCs from the ONFH group were significantly lower as compared with those from the control group. The signal transduction of CD44-ankyrin-Akt-eNOS was significantly repressed in the ONFH group as compared with the control group after hyaluronic acid treatment. Knockdown of ankyrin by siRNA could attenuate the eNOS signaling as well as the BMSCs proliferation and osteogenic differentiation. The proliferation ability and osteogenic differentiation potential of the BMSCs from the ONFH group were significantly reduced as compared with the control group, but they can be enhanced to the baseline levels of the control group by hyaluronic acid treatment.

Conclusion:

The aberrant eNOS signaling, reduced cell proliferation, and osteogenic differentiation potential in BMSCs from ONFH patients are associated with the decreased ankyrin expression.

Clinical Relevance:

Altered signal transduction, proliferation, and osteogenic differentiation ability in BMSCs may be involved in the pathogenesis of ONFH. These need further studies especially in BMSC-based cell therapy.
Relationship Between Blood Flow and Collapse of Nontraumatic Osteonecrosis of the Femoral Head
Authors: Zheng Guo-Shuang , Qiu Xing , Wang Ben-Jie , Zhao De-Wei
Published: April 2022

Background:

To investigate the collapse mechanism in osteonecrosis of the femoral head (ONFH), we studied the relationship between the femoral head (FH) blood circulation changes and the collapse area histomorphometry characteristics.

Methods:

A technique involving microvascular perfusion of the FH in vitro to reconstruct the vessels in the FH at different stages of nontraumatic ONFH (40 cases). In addition, we also examined the histomorphometry characteristics in the collapse area during ONFH at different stages using the hard tissue section technique. To investigate the blood supply changes in the FH on pathological involved in the FH collapse process.

Results:

The results showed that in all FHs, the collapse area always involved the margin of the necrotic lesion of the lateral column. Histologically, the fracture occurred between the thickened and necrotic trabeculae at the junction. We found that the collapse started at the lateral column of the FH in the necrotic lesion and that the lateral column was ischemic, which caused the FH to begin to collapse.

Conclusions:

Based on the above findings, the relationship between associations of the blood circulation to the collapse showed that if a portion of the blood supply of the lateral column (the superior retinacular artery) was preserved, the prognosis of the natural progression of the diseases was improved, the collapse rate was low and collapse occurred later. The blood circulation of artery in the lateral column was good, and the FH maintained an intact shape even if the internal region was ischemic. Therefore, we can predict the collapse of the FH by measuring the blood flow in the lateral area of the FH, thus providing guidance for the selection of FH-preserving clinical therapy in young and middle-aged patients.

Clinical Relevance:

This work provides a proof of how to predict the collapse of the FH by measuring the blood flow, providing guidance for FH-preserving clinical therapy in young and middle-aged patients.
A Case Study on Integrated Modeling of Spatial Information of a Complex Geological Body
Authors: Zhang Peng , Zhang Dingfei , Yang Yang , Zhang Wengang , Wang Yawen , Pan Yajing , Liu Xiaozheng
Published: April 2022

To ensure the safety of project construction and reduce development costs, it is necessary to obtain a reasonable design before project initiation and to analyze and study geological information from multiple perspectives to achieve intuitive and effective project planning. Therefore, it is proposed to integrate above- and underground information to realize integrated spatial information expression. Generally, geological body model construction is based on drilling data, but most geological bodies are not simple layered structures, and complex geological phenomena usually occur, such as faults, lenses, and fissures. It is difficult to construct a high-quality geological body model with only limited drilling data. To fully consider existing geological information in complex geological areas with limited geological data information available, profile maps are considered in the modeling process. This article focuses on the geological model construction of a primary school in Shuicheng County, Guizhou Province, using the GoCAD platform. The Structure and Stratigraphy Workflow is applied in three-dimensional geological body structure model establishment, the stratum rock mass is outlined, and the complex geological structure (karst cave) is embedded into the geological surface. The model can be sliced at any angle to accomplish integrated spatial information expression of above- and underground building information combined with the same platform’s geological body to obtain engineering information and analyze future construction problems.
Super Skills for Life: Eficacia de un programa transdiagnóstico de prevención indicada para los problemas emocionales infantiles
Authors: Fernández-Martínez Iván , Espada José P. , Orgilés Mireia
Published: April 2022

El programa Super Skills for Life es un protocolo de intervención cognitivo-conductual basado en el enfoque transdiagnóstico. Está dirigido a niños de 6 a 12 años con síntomas de ansiedad y/o depresión y consta de 8 sesiones de intervención. Además de los componentes que habitualmente han mostrado su eficacia para la reducción de los problemas emocionales, incluye estrategias como la activación conductual, el entrenamiento en habilidades sociales y el video-feedback con preparación cognitiva previa, que suponen un beneficio añadido. Aunque fue inicialmente creado como un programa de prevención indicada para niños anglosajones, ha sido traducido y adaptado para ser administrado a población infantil española. Los estudios de eficacia que se han llevado a cabo con niños españoles ponen de manifiesto que el programa es capaz de reducir la sintomatología emocional a corto y largo plazo, y que reduce otros síntomas presentes, como problemas de atención e hiperactividad, problemas de conducta o problemas en las relaciones sociales. El programa se encuentra en fase de evaluación para probar su eficacia en otros formatos de aplicación y con otras poblaciones mostrando hasta el momento resultados prometedores
Psychological impact of COVID-19 pandemic in Spanish adolescents: risk and protective factors of emotional symptoms
Authors: Tamarit Alicia , de la Barrera Usue , Mónaco Estefanía , Schoeps Konstance , Montoya-Castilla Inmaculada
Published: April 2022

The psychological impact of the COVID-19 pandemic on children and adolescents is one of the most prevalent concerns all over the world. Adolescence is a developmental stage of high vulnerability due to the challenges this period entails. Additionally, the health emergency crisis has put adolescents even more at risk of developing mental health problems. The present study aims to examine the influence of socio-demographic and COVID-19 related variables on symptoms of depression, anxiety and stress in adolescents during pandemic-related confinement in Spain. Participants were 523 adolescents (63.1% female), aged between 13 and 17 years (M=14.89 years; SD=1.13 years), who completed an ad hoc questionnaire, the Depression, Anxiety and Stress Scale (DASS-21) and The Oviedo Infrequency Scale (INFO-OV). A descriptive and cross-sectional study design was used, and descriptive statistics and multiple logistic regression analyses were conducted. Results indicate that socio-demographic and COVID-19 related variables play a significant role in the development of emotional symptomatology in adolescents during the current pandemic. Girls more than boys, adolescents who did volunteer work and those who stayed home more often were more likely to experience depression, anxiety or stress symptoms. Experiencing a stressing life event and searching for COVID-19 related information more often was related to psychological distress. On the other hand, adolescents who were in a romantic relationship and had been infected with the coronavirus, were more likely to be mentally healthy. Further research is necessary in order to detect risk and protective variables that impact adolescent’s mental health during the COVID-19 pandemic
Psychological effects of the COVID-19 lockdown on children and families in the UK
Authors: Morgül Evren , Kallitsoglou Angeliki , Essau Cecilia A.
Published: April 2022

The implementation of measures (e.g. school closure and social distancing) to contain the spread of COVID-19 by government in numerous countries has affected millions of children and their families worldwide. However, the consequences of such measures on children’s wellbeing are not fully understood. The aim of the present study was to examine the psychological impact of the COVID-19 lockdown on primary school children and their families living in the UK. A total of 927 caregivers with children aged between 5 and 11 years completed an online survey which included a set of questionnaires to measure their own behaviour and emotional state as well as that of their children before and during the lockdown. Caregivers reported changes in their children’s emotional state and behaviours during the lockdown. The most frequently reported child symptom was boredom (73.8%), followed by loneliness (64.5%) and frustration (61.4%). Irritability, restlessness, anger, anxiety, sadness, worry and being likely to argue with the rest of the family was reported by more than 30% of the caregivers. During the lockdown, children spent significantly more time using screens, and less time doing physical activity and sleeping. Moreover, family coexistence during the lockdown was described as moderately difficult. More than half of the caregivers reported being moderately or seriously distressed during the lockdown and caregiver level of psychological distress was significantly related to child symptoms. The findings emphasised the importance of developing prevention programmes to mitigate the impact of COVID-19 pandemic on children’s and their family’s psychological wellbeing
Percepción de prácticas parentales y ansiedad en adolescentes mexicanos
Authors: González-Fuentes Marcela Beatriz , Andrade-Palos Patricia
Published: April 2022

La prevalencia de problemas de ansiedad en adolescentes se ha incrementado en los últimos años en México. Identificar los factores asociados a esta problemática es de gran utilidad para su prevención, detección precoz y tratamiento. El objetivo fue analizar la relación entre la percepción de los adolescentes de las prácticas parentales y la ansiedad Rasgo-Estado. Participaron 809 estudiantes de escuelas públicas de bachillerato en la ciudad de México, de 15 a 20 años, 434 fueron mujeres (56.6%). Todos respondieron la Escala de prácticas parentales (PP) para adolescentes y el Inventario de Ansiedad (A) Rasgo-Estado. Se confirmaron las hipótesis del estudio, la percepción de los adolescentes de las PP positivas de comunicación, control conductual y autonomía se relacionó negativamente con su nivel de A-Rasgo-Estado, y su percepción de las PP negativas de control psicológico e imposición se relacionó positivamente con la A-Rasgo-Estado. Se examinan las implicaciones prácticas de los resultados y se hacen sugerencias para futuras investigaciones