bluuebunny/crossref_metadata_2025 huggingface dataset:
LOGISTICS PLANNING AS AN IMPORTANT ELEMENT OF STRATEGIC DECISIONS IN PRODUCTION MANAGEMENT IN THE COMPANY – CASE STUDY
Authors: ŁUKASIK Zbigniew , KUŚMIŃSKA-FIJAŁKOWSKA Aldona , KOZYRA Jacek , OLSZAŃSKA Sylwia , ROMAN Mateusz
Published: March 2024

The authors have developed algorithms and a simulation model of the production process in the selected enterprise, and proposed variants of emergency conduct. An aggregated simulation model as well as simulation results will allow for the implementation of appropriate procedures for dealing with emergencies. Through employing these measures, audits conducted in the company will reveal how the company is prepared for various failures and what their impact is on the efficiency indicators of the process.
Global Resources and Resource Justice – Lost in Frameworks and the Way Forward
Authors: NEGRUTIU Ioan
Published: March 2024

The lexical analysis of seminal policy-to-diplomacy documents from the socio-environmental discourse of the last fifty year agendas allowed examining the evolution of five themes: resources/waste, pollution, social and economic development, justice, and health. Contextual affinities were strongest between resources, pollution, and health and are linked to societal trends and pressures. On those grounds, the central role of resource stewardship according to nature’s physical limits is highlighted, and dedicated concepts, analytical frameworks, and methodologies with different degrees of sustainability are analyzed. To reframe the identified social and economic problems, the work proposes criteria and choices that (1) allow to compare the dynamics of socioecological states across the planet, (2) help matching the pace of socioecological change by addressing path dependencies through participation and engagement of communities, and (3) enable stakeholders to make trade-offs and take decisions in specific social, economic, political, and cultural contexts. The prioritization of resource justice and responsibility becomes a societal project : from Wellfare State to commonfare communities.
Neobank Adoption and Satisfaction: Insights from University Students
Authors: Matraku Gerandi
Published: March 2024

This research explores the influence of nationality and financial literacy on satisfaction with neobank services among university students. Through a comparative analysis between German and international students, the study unveils that international students exhibit significantly higher satisfaction levels, suggesting that cultural differences and the requirement for international financial services play a crucial role Oishi et al., 1999. Although financial literacy was anticipated to have a strong impact, its effect on satisfaction did not reach statistical significance, indicating a nuanced relationship. This perhaps because the study sample of students partaking in the survey was mostly Graduate students in the field of Economics, Finance and Management. Demographic factors such as gender and age were found to be less influential compared to nationality and financial acumen Gelfand et al., 2011. These findings highlight the importance of tailored financial services and the potential of financial education in enhancing neobank satisfaction Gerrans et al., 2014. The study contributes to the understanding of consumer behavior in digital banking, offering insights for neobanks aiming to improve service adoption and customer loyalty within the university student demographic.
Web Application for Retrieval-Augmented Generation: Implementation and Testing
Authors: Radeva Irina , Popchev Ivan , Doukovska Lyubka , Dimitrova Miroslava
Published: March 2024

The purpose of this paper is to explore the implementation of Retrieval-Augmented Gen- 14 eration (RAG) technology with open-source Large Language Models (LLMs). For this purpose, a 15 web-based application named PaSSER that integrates RAG with three models - Mistral:7b, 16 Llama2:7b: Orca2:7b, is developed. In its development various technologies are used, including 17 Blockchain for managing and storing assessment results of built-in testing modules. PaSSER em- 18 ploys a set of evaluation metrics for LLMs’ performance - METEOR, ROUGE, BLEU, Perplexity, 19 Cosine similarity, Pearson correlation, and F1 score. The specialized knowledge base is in the smart 20 agriculture domain. As an illustration, the paper presents results and analysis of two tests. First one 21 is assessing the performance of LLMs across different hardware configurations, the other is deter- 22 mining the model that delivers most accurate and contextually relevant responses within the RAG. 23 The paper also discusses the integration of blockchain technology with LLMs to manage and store 24 assessment results within a blockchain environment. The tests revealed that Mistral:7b demon- 25 strates the best results across most of the evaluated metrics. The discussion section comments on 26 technical and hardware considerations that affect the performance of LLMs. Future development 27 will focus in leveraging new larger pre-trained open-source LLMs, exploring different finetuning 28 approaches, and further integration with Blockchain and IPFS.
Enabling Low-Dose In Vivo Benchtop X-ray Fluorescence Computed Tomography through Deep Learning-Based Denoising
Authors: Mahmoodian Naghmeh , Rezapourian Mohammad , Inamdar Asim Abdulsamad , Kumar Kunal , Fachet Melanie , Hoeschen Christoph
Published: March 2024

X-ray Fluorescence Computed Tomography (XFCT) is an emerging non-invasive imaging technique providing molecular-level data, gaining attention for high-resolution imaging. However, increased sensitivity with benchtop X-ray sources raises radiation exposure. Artificial Intelligence (AI), particularly deep learning (DL), has revolutionized medical imaging by delivering high-quality images in the presence of noise. In XFCT, traditional methods rely on complex algorithms for noise reduction, but AI holds promise in addressing high-dose concerns. We present an optimized SCUNet model for noise reduction in low-concentration XRF images. Compared to higher-dose images, our method’s effectiveness is evaluated. While various denoising techniques exist for X-ray and CT, few address to XFCT. The DL model is trained and assessed using the augmented data, focusing on background noise reduction. Image quality is measured using PSNR and SSIM, comparing outcomes with 100% X-ray dose images. Results show the proposed algorithm achieves high-quality images from low-dose and low-contrast agents, with a maximum PSNR of 39.05 and SSIM of 0.86. The model outperforms BM3D, NLM, DnCNN, and SCUNet in both visual inspection and quantitative analysis, particularly in high-noise scenarios. This indicates the potential of AI, specifically the SCUNet model, in significantly improving XFCT imaging by mitigating the trade-off between sensitivity and radiation exposure.
On the Unique Morphology and Elastic Properties of Multi-jet Electrospun Cashew Gum-Based Fiber Mats
Authors: Grumi Mattia , Prieto Cristina , Furtado Roselayne Ferro , Cheng H. N. , Biswas Atanu , Limbo Sara , Cabedo Luís , Lagaron Jose M.
Published: March 2024

This study investigates the unique morphology and mechanical properties of multi-jet electrospun cashew gum (CG) when combined with high molecular weight polyethylene oxide (PEO) and glycerol. Cashew gum (CG) is an inexpensive, non-toxic polysaccharide derived from Anacardium occidentale trees. Initially, the electrospinnability of aqueous solutions of cashew gum alone or in combination with PEO was evaluated. It was found that cashew gum alone was not suitable for electrospinning; thus, adding a small quantity of PEO was needed to create the necessary molecular entanglements for fiber formation. By using a single emitter with a CG:PEO ratio of 85:15, straight and smooth fibers with some defects were obtained. However, additional purification of the cashew gum solution and the incorporation of glycerol as a plasticizer were necessary to produce defect-free straight and smooth fibers. Interestingly, when the optimized formulation was electrospun using multiple simultaneous emitters, thicker aligned fiber bundles were achieved. Moreover, the resulting oriented fiber mats exhibited unexpectedly high elongation at break at ambient conditions. These findings highlight the potential of this bio-polysaccharide-based formulation for non-direct water contact applications requiring elastic properties.
Ageing of a Poly(vinyl Acetate)-Based White Glue and Its Durability in Contemporary Artworks
Authors: Lazzari Massimo , López Morán Thais
Published: March 2024

Poly(vinyl acetate) (PVAC) is a ubiquitous polymer in various industrial applications, including paints and adhesives. While extensive research has focused on understanding the degradation mechanisms of PVAC-based paint, under different environmental conditions, limited attention has been paid to the long-term stability of PVAC-based white glues, especially when used in artworks. This study investigates the accelerated degradation of a commercial PVAC-based white glue considered as representive of this class of materials as used in contemporary artworks, to predict its durability and assess its behavior in art objects. Through accelerated aging experiments and comparison with natural aging observed in artworks, the study reveals the formation of chromophores and the release of plasticizer as key degradation processes. Despite minimal structural modifications in PVAC, the loss of plasticizer leads to an increase in glass transition temperature, affecting the adhesive's cohesive strength and contributing to detachment of materials in artworks. The findings underscore the importance of preventive conservation measures to mitigate degradation issues in PVAC-based artworks.
In-Situ Screening of Defective Electronic Components through Edge Real-Time Big Data AI Analysis
Authors: Weiss Eyal , Caplan Shir , Horn Jacob , Sharabi Moshe
Published: March 2024

This paper presents a groundbreaking approach to real-time image processing in electronic component assembly, enhancing quality control in manufacturing. By capturing images from pick and place machines between component pickup and mounting, defects are identified and addressed in-line, significantly reducing the likelihood of defective products. Leveraging fast network protocols like gRPC and orchestration with Kubernetes, along with C++ programming and TensorFlow, this method achieves an average turnaround time of less than 5 milliseconds. Tested on 20 live production machines, it ensures compliance with IPC-A-610, and IPC-STD-J-001 standards while optimizing production efficiency and reliability.
Bridging the Gap between Academia and Society: Research, Training and Strategic Alliances for Sustainable Development
Authors: Posadas de Julián Pilar , Verdejo Lucas Carmen , De Rueda Villén Belén , Haro-Soler M. del Mar , Gijón Puerta José , Cámara Aguilera Elvira , García de Quesada Mercedes
Published: March 2024

We are currently facing a potential ‘polycrisis’, a critical inflection point that requires a whole-of-society response aimed at building collective foresight and preparedness for short-, medium-, and long-term risks. The role of higher education institutions and social stakeholders is decisive to make an impact. This paper depicts the alignment of academia, governance, and industry with the aim to challenge, inspire, and encourage universities to go beyond commodified courses and mere employability, enhance student growth and bind macro-scale measures that lead to a sustainable future. A modest teaching innovation project has served as a transforming lever, with the private sector joining in, to create a platform that reaches more than 50 000 undergraduate students and teaching staff. The resulting structure, rooted in the University’s strategic plan, has served to channel local and regional initiatives, establish effective partnerships with broad social members, raise awareness and promote actions to advance in the pursuit of Sustainable Development Goals. Chronology, materials and methodology, together with a description of the different courses, programmes and actions are provided. The paper concludes with some recommendations for future research, policy and cooperation among stakeholders. Research methodology posted on clinicaltrials.gov under ID NCT04392869, NCT05598944, and NCT05775978.
Frilled Lizard Optimization: A Novel Nature-Inspired Metaheuristic Algorithm for Solving Optimization Problems
Authors: Falahah Ibraheem Abu , Al-Baik Osama , Alomari Saleh , Bektemyssova Gulnara , Gochhait Saikat , Leonova Irina , Malik Om Parkash , Werner Frank , Dehghani Mohammad
Published: March 2024

This article introduces a novel nature-inspired metaheuristic algorithm called Frilled Lizard Optimization (FLO), which emulates the hunting behavior of frilled lizards in their natural habitat. FLO draws in-spiration from the sit-and-wait strategy observed in frilled lizards during hunting. The underlying theory of FLO is presented and mathematically formulated in two phases: (i) an exploration phase, simulating the frilled lizard's attack towards prey, and (ii) an exploitation phase, simulating the lizard's retreat to the top of the tree after feeding. To assess FLO's efficacy in solving optimization problems, the algorithm's performance is evaluated across fifty-two standard benchmark functions, encompassing unimodal, high-dimensional multimodal, fixed-dimensional multimodal, and the CEC 2017 test suite. Comparative analyses with twelve existing metaheuristic algorithms are conducted. The simulation results reveal that FLO, distinguished by its adeptness in exploration, exploitation, and balancing them during search process, outperforms competing algorithms. Additionally, FLO is implemented on twenty-two constrained optimization problems from the CEC 2011 test suite and four engineering design problems, demonstrating its effectiveness in addressing real-world optimization applications.
Gut Microbiota a Novel Source of Biomarkers for Immunotherapy in Non-small Cell Lung Cancer (NSCLC)
Authors: Del Giudice Teresa , Staropoli Nicoletta , Tassone Pierfrancesco , Tagliafeerri Pierosandro , Barbieri Vito
Published: March 2024

Despite the recent availability of immune checkpoint inhibitors, not all patients affected by Non-Small Cell Lung Cancer (NSCLC) benefit from immunotherapy. The reason for this variability relies to a variety of factors which may allow the identification of novel biomarkers. Presently, a variety of biomarkers are under investigation, including the PD1/PDL1 axis, the tumor mutational burden, and the Microbiota. This latter is made by all bacteria and other microorganisms hosted in our body. The gut microbiota is the most represented and has been involved in different physiological and pathological events, including cancer. In this light, it appears that all conditions modifying gut microbiota can influence cancer, its treatment, and its treatment-related toxicities. The aim of this review is to analyze all conditions influencing the gut microbiota and, therefore, affecting response to immunotherapy, iRAEs and their management in NSCLC patients. The investigation of the landscape of these biological events can allow novel insights for optimal management of NSCLC immunotherapy.
Oleanolic Acid Acetate Alleviates Cisplatin-Induced Nephrotoxicity Via Inhibition of the Caspase and RIPK Pathways
Authors: Lee Bori , Kim Yeon-Yong , Jeong Seungwon , Lee Seung Woong , Lee Seung-Jae , Rho Mun-Chual , Kim Sang-Hyun , Lee Soyoung
Published: March 2024

Cisplatin is a widely used anticancer drug for treating solid tumors, but it is associated with severe side effects, including nephrotoxicity. Various studies have suggested that the nephrotoxicity of cisplatin could be overcome; nonetheless, an effective adjuvant drug has not yet been established. Oleanolic acid acetate (OAA), a triterpenoid isolated from Vigna angularis, is commonly used to treat inflammatory and allergic diseases. This study aimed to investigate the protective effects of OAA against cisplatin-induced apoptosis and necroptosis using TCMK-1 cells and a mouse model. In cisplatin-treated TCMK-1 cells, OAA treatment significantly reduced Bax and cleaved-caspase3 expression, whereas increased Bcl-2 expression. Moreover, in cisplatin-induced kidney injury mouse model, OAA treatment alleviated weight loss in the body and major organs and also relieved cisplatin-induced nephrotoxicity symptoms. RNA sequencing analysis of kidney tissues identified lipocalin-2 as the most upregulated gene by cisplatin. Additionally, necroptosis-related genes such as receptor interacting protein kinase (RIPK) and mixed lineage kinase domain like (MLKL) were identified. In vitro study, the phosphorylation of RIPKs and MLKL was reduced by OAA pretreatment in both cisplatin-treated cells and cells boosted by co-treatment with z-VAD-FMK. In conclusion, OAA could protect the kidney from cisplatin-induced nephrotoxicity and may serve as an anticancer adjuvant.
Genomic Characterization of Partial Tandem Duplication Involving the KMT2A Gene in Adult Acute Myeloid Leukemia
Authors: Seto Andrew , Downs Gregory , King Olivia , Salehi-Rad Shabnam , Baptista Ana , Chin Kayu , Grenier Sylvie , Nwachukwu Bevoline , Minden Mark David , Smith Adam , Capo-Chichi Jose-Mario
Published: March 2024

Background. Gene rearrangements affecting KMT2A are frequent in acute myeloid leukemia (AML) and are often associated with a poor prognosis. KMT2A gene fusions are often detected by chromosome banding analysis and confirmed by fluorescence in-situ hybridization. However, small intragenic insertions, termed KMT2A partial tandem duplication (PTD), are particularly challenging to detect using standard molecular and cytogenetic approaches. Methods. We have validated the use of a custom hybrid capture based next-generation sequencing (NGS) panel for comprehensive profiling of AML patients seen at our institution. This NGS panel targets the entire consensus coding DNA sequence of KMT2A; to deduce the presence of a PTD we used the relative ratio of KMT2A exons coverage. We sought to corroborate the KMT2A-PTD NGS results using (1) multiplex-ligation probe amplification (MLPA) and (2) optical genome mapping (OGM). Results. We analyzed 932 AML cases and identified 41 individuals harboring a KMT2A-PTD. MLPA, NGS and OGM confirmed the presence of a KMT2A-PTD in 22 of the cases analyzed where orthogonal testing was possible. Two false positive PTD calls by NGS could be explained by the presence of cryptic structural variants impacting KMT2A and interfering with PTD analysis. OGM revealed the nature of these previously undetected gene rearrangements in KMT2A, while MLPA yielded in-conclusive results. MLPA analysis for KMT2A-PTD is limited to exon 4, whereas NGS and OGM resolved KMT2A-PTD sizes and copy number levels. Conclusion. KMT2A-PTDs are complex gene rearrangements that cannot be fully ascertained using a single genomic platform. MLPA, NGS panels and OGM are complementary technologies applied in standard of care testing for AML patients. MLPA and NGS panels are designed for targeted copy number analysis; however, our results show that integration of concurrent genomic alterations is needed for accurate KMT2A-PTD identification. Unbalanced chromosomal rearrangements overlapping with KMT2A can interfere with the diagnostic sensitivity and specificity of copy number based KMT2A-PTD detection methodologies.
RNA Interference-Mediated Suppression of Ecdysone Signaling Inhibits Choriogenesis in two Coleoptera species
Authors: Zhang Xiao-Qing , Jin Lin , Guo Wen-Chao , Fu Kai-Yun , Li Guo-Qing
Published: March 2024

During choriogenesis in insects, chorion (eggshell) is formed by surrounding follicular epithelial cells in ovarioles. However, the regulatory endocrine factor(s) activating choriogenesis and the chemical components on eggshell deserve further exploration. In two representative Coleopterans, a Coccinellid Henosepilachna vigintioctopunctata and a Chrysomelid Leptinotarsa decemlineata, genes encoding the 20-hydroxyecdysone (20E) receptor heterodimer, ecdysone receptor (EcR) and ultraspiracle (USP), and two chitin biosynthesis enzymes UDP-N-acetylglucosamine pyrophosphorylase (UAP) and chitin synthase (ChS1), were highly expressed in ovaries of the young females. RNA interference (RNAi)-aided knockdown of either HvEcR or Hvusp in H. vigintioctopunctata inhibited oviposition, suppressed the expression of HvChS1, and lessened the positive signal of Calcofluor staining on the chorions, which suggests the reduction of a chitin-like substance (CLS) deposited on eggshells. Similarly, RNAi of LdEcR or Ldusp in L. decemlineata constrained oviposition, decreased the expression of LdUAP1 and LdChS1, and declined CLS contents in the resultant ovaries. Knockdown of LdUAP1 or LdChS1 caused similar defective phenotypes, i.e., reduced oviposition and CLS contents in the L. decemlineata ovaries. These results, for the first time, indicate that 20E signaling activates choriogenesis in two Coleopteran species. Moreover, our findings propose the deposition of a CLS on the chorions.
A Comparative Experimental and Computational Study on the Nature of the Pangolin-CoV and COVID-19 Omicron
Authors: Wei Lai , Song Lihua , Dunker A. Keith , Foster James A. , Uversky Vladimir N. , Goh Gerard Kian-Meng
Published: March 2024

The relationship between pangolin-CoV and SARS-CoV-2 has been a subject of debate. Further evidence of a special relationship between the two viruses can be found by the fact that all known COVID-19 viruses have abnormally hard outer shell (low M disorder; i.e., low content of intrinsically disordered residues in the membrane (M) protein) that so far was found in CoVs associated with burrowing animals, such as rabbits and pangolins, in which transmission involves virus remaining in buried feces for a long time. While a hard outer shell is necessary for viral survival, a harder inner shell could also help. For this reason, the N disorder range of pangolin-CoVs, not bat-CoVs, more closely matches that of SARS-CoV-2 especially when Omicron is included. The low N disorder (i.e., low content of intrinsically disordered residues in the nucleocapsid (N) protein), first observed in pangolin-CoV-2017 amd later in Omicron, is associated with attenuation according to the Shell-Disorder-Model. Our experimental study revealed that pangolin-CoV-2017 and SARS-CoV-2 Omicron (XBB.1.16 subvariant) show similar attenuations with respect to viral growth and plaque formation. Subtle differences have been observed that are consistent with disorder-centric computational analysis.
Deep Learning Guided Prediction Modeling of Dengue Virus Evolving Serotype
Authors: Mumtaz Zilwa , Shahbaz Hafiz Abdullah , Qureshi Muhammad Hamza , Saif Rashid , Yousaf Muhammad Zubair
Published: March 2024

Evolution remains an incessant process in viruses, allowing them to elude host immune response and induce severe diseases, impacting the diagnostic and vaccine effectiveness. Predicting emerging viral genomes is crucial, particularly in diseases like dengue, where viruses disrupt host cells, leading to fatal outcomes. Deep learning has been applied to predict dengue fever cases; there has been relatively less emphasis on its significance in forecasting emerging Dengue Virus (DENV) serotype. While Recurrent Neural Networks (RNN) were originally designed for modeling temporal sequences, our proposed DL-DVE generative and classification model, trained on complete genome data of DENV, transcends traditional approaches by learning semantic relationships between nucleotides in a continuous vector space instead of representing contextual meaning of nucleotide characters. Leveraging 2000 publicly available DENV complete genome sequences, our Long Short-Term Memory (LSTM) based generative and Feedforward Neural Network (FNN) based classification DL-DVE model showcases proficiency in learning intricate patterns and generating sequences for emerging serotype of DENV. The generative model showed accuracy of 93% and the classification model provided insight into the specific serotype label, corroborated by BLAST search verification. Evaluation metrics such as ROC-AUC value 0.818, accuracy, precision, recall and F1 score all to be around 99.00%, demonstrated the classification model’s reliability.  Our model classified the generated sequences as DENV-4, exhibiting 65.99% similarity to DENV-4 and around 63-65% similarity with other serotypes, indicating notable distinction from other serotypes. Moreover, the intra-serotype divergence of sequences with a minimum 90% similarity underscored their uniqueness. We analyzed the conserved motifs in the genome through MEME Suite (version 5.5.5). Our research strives to contribute to the ongoing fight against the Dengue virus by offering predictive insights into its genomic evolution. Looking ahead, proactive predictive modeling before mutations occur holds potential for guiding vaccine design and diagnostic kit development.
In Vitro Resensitization of Fluoroquinolones and Carbapenems Against Biofilm-Forming and Multidrug-Resistant Salmonella and Shigella spp. Using Riboflavin
Authors: Abban Molly Kukua , Mensa Mathew , Gayi Blessing , Addo Gloria Kutorkor , Ofori Maame Ekua Oforiwaa , Ayerakwa Eunice Ampadubea , Isawumi Abiola
Published: March 2024

Shigella and Salmonella have been implicated in neonatal sepsis, food poisoning, and bacteremia. Their increasing resistance to antibiotics has undermined treatment options, constituting a public health crisis. Also, the scarcity of new antibiotics in the development pipeline compounds multidrug-resistance (MDR). Hence, there is a need to potentiate antibiotics to mitigate resistance. This study leveraged riboflavin to re-sensitize fluoroquinolones and carbapenems against MDR Shigella and Salmonella spp. Disk diffusion, microbroth-dilution, chequerboard, and time-kill assays were used to determine resistance profiles and riboflavin-antibiotic activity. Biofilm-formation and bacterial viability (after riboflavin-antibiotic challenge) was determined with crystal-violet and Macrophage infection assays, respectively. Strains exhibited >80% resistance to fluoroquinolones and carbapenems, with 160–320 µg MIC ranges and 0.5–2 FIC, indicating no synergy. At 40–80 µg riboflavin, there was two-fold reduction in bacterial survival, with meropenem-riboflavin exhibiting significant reduction and FIC of 0.075 indicating high synergistic activity. Biofilm-formation was altered (from strong to weak phenotype) with 40 µg riboflavin-antibiotic treatment. There was a 40–70% reduction in bacterial survival in THP-1 cells treated with meropenem-riboflavin after 3 hours, and complete clearance between 24-48 hpi. Riboflavin potentiated fluoroquinolones and meropenem, leading to modulation of the host immune response for the clearance of the strains.
Colorectal Cancer Pulmonary Metastasectomy: When, Why and How
Authors: Petrella Francesco , Danuzzo Federica , Sibilia Maria Chiara , Vaquer Sara , Longarini Raffaella , Guidi Alessandro , Raveglia Federico , Libretti Lidia , Pirondini Emanuele , Cara Andrea , Cassina Enrico Mario , Tuoro Antonio , Cortinovis Diego
Published: March 2024

Colorectal cancer is the third most diagnosed cancer in males and in females, representing 8% of estimated new cases and the third cause of cancer-related death in both sexes, accounting for 9% of cancer deaths in men and 8% in women. About 20% of patients diagnosed with CRC present metastatic disease. Although lung metachronous or synchronous metastatic spread without other involved sites has been reported in only a small proportion of patients, considering that this tumor is frequently diagnosed, the clinical approach to CRC pulmonary metastases represents a major issue for thoracic surgeons and CRC oncologists. Among patients diagnosed with pulmonary metastases from CRC, about 9 – 12% are eligible for local treatments with radical intent, including surgical resection, SBRT and ablation therapy. Due to the lack of randomized controlled trials among different local strategies, there is no definitive evidence about the optimal approach, although surgical resection is considered the most effective therapeutic option in this clinical scenario. Oncological achievement of primary radical resection, the biology of primary tumor and metastatic sites, disease free interval and or progression free survival are independent prognostic factors which make it possible to define a cohort of patients which might significantly benefit from pulmonary metastasectomy.
On a New Theory of Climate Interference for MISs and Glacial Terminations from Antarctica Ice-core Records. 1: Interference Model
Authors: Viaggi Paolo
Published: March 2024

Variance-driven decomposition based on the singular spectrum analysis of the European Project for Ice Coring in Antarctica (EPICA) dD, CO2 and CH4 records allowed a novel quantitative structural interpretation of all glacial/interglacial cycles and glacial terminations of the last 800 kyr. This bottom-up approach used the response components of EPICA stacked records to reconstruct the envelope of the thermal response through a physical interference model. The aim was to improve the understanding regarding the features of intensity, amplitude, and asymmetry of 73 marine isotope stages (MIS) and seven terminations. The Antarctic stack record can be described by a variance-weighted interference model of ten thermal waves of different origins (mid-term oscillation, orbitals and suborbitals) that stochastically interfere at a given time according to their relative differences in frequency, intensity, and polarity. Interglacial/glacial stages resulted from constructive interference and bipolar amplification of warming/cooling responses, respectively. The low intensity MISs (including 90% of substages) and the unbiased-dated terminations fell in the low interference regions where dominant destructive patterns minimise the thermal envelope. The positive skewness of the EPICA stack resulted from the constructive interference with a strong bias in the warming direction, especially after the Mid-Brunhes Event. Duration analysis of short eccentricity hemicycles exhibited an intrinsic unexpectedly prolonged mean cooling in the nominal solution (5.8 kyr) and its EPICA response as well (8.6 kyr), along with an interference-induced asymmetry (21.1 kyr). The overall effect resulted in the saw-tooth shape of glacial cycles which is heavily induced by interference and related to the intermediate feedback mechanisms controlled by short eccentricity.
Environmental Surveillance through Machine Learning-Empowered Utilization of Optical Networks
Authors: Awad Hasan , Usmani Fehmida , Virgillito Emanuele , Bratovich Rudi , Proietti Roberto , Straullu Stefano , Pastorelli Rosanna , Curri Vittorio
Published: March 2024

Exploiting the existing optical fiber network’s terrestrial infrastructure offers unexpected solutions to global challenges. We aim to expand the current network by incorporating a streaming telemetry system to integrate earthquake early detection. The purpose is to analyze and interpret alteration of light’s polarization induced by seismic events, particularly Primary earthquake waves that precede destructive Surface waves. This analysis facilitates the development of an early warning system and implementation of earthquakes countermeasures to mitigate humanitarian and economic impact. Consequently, we have developed a Python-based Waveplate Model designed to monitor light’s polarization changes within optical fibers buried underground. The model incorporates real ground displacement data from a 4.9 magnitude earthquake that struck in Marradi region, central Italy. We propose a novel approach of a smart sensing grid of optical network empowered by machine learning, trained on a large number of polarization evolution extracted from two distinct sensing fibers to identify the pattern of polarization change occurring during Marradi earthquake. Test Results demonstrate that this method can detect Primary waves within one second time-frame, achieving an accuracy rate of 99.5%. This system therefore affords nearby regions 52 seconds to take emergency response, and an extended margin of 62 seconds in more distant areas.
Machine Learning Models Predicting Incidence, Severity, and Early Outcomes of Hemorrhagic Stroke from Weather Parameters and Individual Risk Factors
Authors: Statsenko Yauhen , Fursa Ekaterina , Laver Vasyl , Talako Tatsiana , Simiyu Gillian Lylian , Al Zahmi Fatmah , Smetanina Darya , Gorkom Klaus Neidl-Van , Szolics Miklos , Al. Koteesh Jamal , Almansoori Taleb M. , Ljubisavljevic Milos
Published: March 2024

Herein, we examined the effects of weather parameters and individual clinicodemographic risk factors on hemorrhagic stroke (HS) incidence, severity on admission, and disability at discharge in a harsh desert climate. In a retrospective design we studied patients admitted to a stroke unit in Arab Emirates in 2016-2019. With a distributed lag nonlinear model we explored immediate and delayed effects of weather on stroke incidence. Supervised machine learning was used to build models predictive of scores in NIHSS and mRS scales. We assessed model performance by calculating ROC AUC, F1 scores, specificity, and sensitivity. HS risk increased after a significant change in any weather parameter. The risk was reduced below baseline after 1-week adjustment to environmental changes. Climate input from the previous 3 days yielded reliable classification models. Humidex was a better predictor of severity than air temperature, whereas body mass index, age, and time of day at stroke onset were the strongest clinical predictors. Weather parameters before admission were stronger predictors of disease severity than individual clinical factors. We addressed limitations of previous studies by analyzing a full set of climate parameters: ambient temperature, relative humidity, humidex, atmospheric pressure, and wind speed. Predictive models may help to optimize patient management and develop preventative strategies.
Study on the Suspension Mechanism and Critical Formula of the Epipelic Algae Group on the Side Wall of the Channel
Authors: Pan Li , Wu Guoying , Zhang Mingwu , Zhang Yuan , Wang Zhongmei , Lai Zhiqiang
Published: March 2024

When the epipelic algae group growing on the concrete inclined side wall, which is typical of urban rivers and open diversion channels, enters the water flow, it will seriously affect the func-tion of the rivers or the channels. It is urgent to predict the transport capacity of epipelic algae group with water flow. However, the current research on the transport of pollutants is mostly based on mathematical models, and the study of the transport of flake epipelic algae group is extremely rare. A generalized hydrodynamic experimental model of a flume with sidewall epi-pelic algae group was established. Through a series of hydraulic experiments, the physical movement form and transport capacity of the suspended epipelic algae group on the side wall of the channel were studied qualitatively and quantitatively by taking the thickness, sheet size and flow rate of the epipelic algae group as the influencing factors. The key influencing factors of the suspension of epipelic algae are clarified, so as to quantitatively analyze the critical conditions of its suspension. Through flow scheduling, the probability of epipelic algae gathering some-where is increased. It provides a theoretical basis for realizing the long-distance migration of epipelic algae and optimizing the mathematical model.
Analisis Implementasi Food Waste Management
Authors: Alfiansyah Mi'raj Muhamad
Published: March 2024

This research aims to investigate the phenomenon of food waste and the implementation of food waste management at hotel Novotel Jakarta Cikini, Central Jakarta, as part of their efforts to reduce leftover food waste. The study employs a qualitative descriptive approach. The respondents in this research consist of 5 individuals who are employees of hotel Novotel Jakarta Cikini from various departments directly involved in the food waste management implementation. The research was conducted in June 2023. Data collection techniques included interviews, observations, and documentation.The research findings indicate that the food waste management implemented by hotel Novotel Jakarta CIkini  is quite effective, resulting in a reduction of approximately 63 percent in the amount of food waste, from 123 kg per day to around 77.5 kg per day. The food waste management practices at hotel Novotel Jakarta Cikini align with several supporting theories, such as adjusting the size of food portions, processing leftover food materials, donating reprocessed food, and creating organic compost from food waste. Additionally, the study identifies some challenges faced by the hotel employees in educating guests and dealing with internal issues, which have impacted the implementation of food waste management. Furthermore, the research identifies the causes of food waste, ranging from leftover guest meals to unused food ingredients scheduled for processing, as well as the methods employed by hotel Novotel Jakarta Cikini to reduce the accumulation of food waste.
Pengetahuan Higiene Sanitasi Terhadap Perilaku Hidup Bersih dan Sehat (PHBS) Pelaku Usaha Makanan di Desa Wisata Edukasi Cisaat
Authors: Aviani Fitta , Abdullah Mashabi Nurlaila , Mulyati Mulyati
Published: March 2024

Abstrak

Desa Wisata Edukasi Cisaat merupakan salah satu desa wisata edukasi yang terletak di Kecamatan Ciater, Subang, Jawa Barat. Sebagai salah satu bentuk pemenuhan kebutuhan utama, manusia memerlukan makanan untuk mengisi tenaga dan nutrisinya untuk dapat beraktivitas. Tingginya kebutuhan akan makanan, menjadi salah satu peluang usaha yang dapat dijalankan di daerah desa wisata. Pelaku usaha kuliner atau makanan harus memerhatikan aspek kebersihan dan kesehatan guna memberikan produk terbaik untuk konsumen. Dalam rangka meningkatkan promosi kesehatan, pemerintah menggalakkan program Perilaku Hidup Bersih dan Sehat (PHBS).  Untuk meningkatkan kesehatan yang lebih baik dalam masyarakat, dibutuhkan pengetahuan penunjang perilaku. Sebelum seseorang mengadopsi perilaku baru, tentunya perlu sebuah pendorong atau informasi. Pengetahuan yang dibutuhkan pelaku usaha makanan yaitu salah satunya terkait kebersihan diri sendiri dan lingkungan atau bisa disebut higiene sanitasi. Adapun tujuan penelitian ini adalah untuk mengetahui pengaruh pengetahuan higiene sanitasi terhadap Perilaku Hidup Bersih dan Sehat (PHBS) pada pelaku usaha makanan di Desa Wisata Edukasi Cisaat. Metode yang digunakan pada penelitian ini adalah kuantitaitf asosiatif, dengan menggunakan random sampling. Populasi penelitian ini berjumlah 147 orang dengan uji validitas sebanyak 30 orang menggunakan populasi yang sama. Berdasarkan hasil penelitian yang telah dilakukan dapat disimpulkan bahwa pengetahuan higiene sanitasi berpengaruh signifikan  ke arah positif terhadap Perilaku Hidup Bersih dan Sehat (PHBS).

Kata kunci: desa wisata, PHBS, higiene, sanitasi
The POTENSI PENGEMBANGAN WISATA AIR BELANTING RIVER TUBING DI DESA WISATA KELUMPANG KABUPATEN OGAN KOMERING ULU
Authors: Permatasari Mustika
Published: March 2024

The musi river hosts one of the water Tours known as the river tour. Musi river tour isa trip that nicmatin tourists use using tourist boats. Certainly musi river touris one of the many tourists able to attract tourists to the city of palembang. According to the researchers' observation that tourist attractions in the musi river have not yet met the components of the good attraction this shows a variety of activities, an inn accommodations are not available and a lack of promotion activities to bring tourists to the musi river. The purpose of this study is to know the potential in the palembang city musi river seen from attractions, amenities and accessibility to can increase the number of tourist visits. Research methods to be used in this study will use qualitative research methods with a case study approach. Using the type of case study, it aims to provide a description of the potential tourist attraction of the musi river. The results and conclusions of this study that the potential of the musi river has given a high opportunity to develop as a tourist attraction. And currently includes the preeminent tourist destination held by the city of palembang. The potential that can support such development as its good cultural and environmental presence can add to the richness of local cultural objects and attractions.
Moral Education of Muslim Children in Islamic Minority Countries (Phenomenological Studies in Germany and the Netherlands)
Authors: Rahmatullah Azam Syukur , Purnomo Eko Priyo , Othman Mohd. Sukki , Aziz Akbar Nur
Published: March 2024

Moral education is an element that must be embedded from an early age, where true morals originate in a healthy soul, and are supported by a strengthening spiritual element, to give birth to children with positive morals. Moral education should ideally be taught in any condition and situation, both in Muslim-majority and Muslim-minority countries.  This study aims to determine how moral conditions, problems experienced by parents in educating Islam-based morals, and the process carried out by parents in educating their children's morals in non-Muslim countries. Germany and Amsterdam were used as research sites because both countries are known as Islamic minority countries.  This research uses phenomenological research methods with a qualitative approach. Participant data came from parents who had the following criteria have lived in Germany or Amsterdam for at least 2 years, Indonesian parents who are Muslims, and parents who educate their children directly related to morals and are not represented by caregivers / domestic assistants. Research data were obtained from interviews and observations and then analyzed using phenomenological study techniques. The results showed that parents apply authoritarian and democratic parenting. The efforts made by parents in educating children's morals include storytelling methods, role models, direct learning, and reward and punishment. Obstacles faced by parents include internal and external obstacles, namely the lack of academics or facilities to obtain sources of Islamic knowledge as well as the busyness of parents. The pattern of moral education of children for Muslim minorities is carried out through faith-based private schools (Islam), informal homeschooling, colleges (universities and colleges), mosques (Islamic centers), and Islamic organizations.
Caring for the Mental Health of Patients at Aisyiyah Hospital through Spiritual Guidance
Authors: Zaini Ahmad
Published: March 2024

Caring for the mental health of patients receiving treatment in hospitals is an urgent matter to be implemented. This research discusses the process of spiritual guidance for patients, therefore the aim of this study is to analyze the process of spiritual guidance in caring for the mental health of patients at Aisyiyah Hospital during their stay in the hospital. This study is a qualitative research. Data collection was done through observation, interviews, and documentation. In this case, information was sought from the spiritual guidance department. The data analysis used in this study was through data reduction, data display, and verification. The research result shows that the role of spiritual guidance for patients at the hospital is an important activity to be implemented as it can accelerate the healing process when patients have a healthy mindset. The challenges faced by the spiritual guidance department can be minimized by collaborating with religious organizations that have many experts in the field of religion, taking into account the expertise of these experts.
Implementation of Interactive Books Based on Local Wisdom and STEAM as Creative Learning in Islamic Early Childhood Education
Authors: Qomariah Choirul , Yulia Nikmahtul Khoir Tri
Published: March 2024

This research aims to investigate the implementation of interactive books based on local wisdom and STEAM as a creative learning tool in Islamic Early Childhood Education, through a case study method. The study was conducted at KB-TA Amanah Bunda Lawang, Malang, focusing on the local wisdom of East Javanese language and the theme of creating traditional toys for children. Data were obtained through observations, where 80% of the students were observed learning through interactive books using the STEAM approach, and 90% of the students actively engaged in creating loose part toys after the book was read. Furthermore, feedback from the students and teachers indicated that there is a need to synchronize the illustrations and text in the STEAM interactive book. These findings provide valuable insights into the effectiveness and further development needs regarding the implementation of interactive books based on local wisdom and STEAM in KB-TA Amanah Bunda Lawang. The research recommendations include the development of more visually integrated and culturally relevant STEAM interactive books, as well as the use of teaching methods that support children's creativity and active participation.
Learning Strategies of Local Cultural Literacy in Early Chidhood
Authors: Nurjanah Ayu , Riusdi Riko , Naimah Naimah , Rohimah Yuliatur
Published: March 2024

The rapid development of the times resulted in the displacement of local culture. Literacy is present as one of the steps to foster a sense of love for the local local culture. The purpose of this study is to describe learning strategies of local cultural literacy in early childhood. This study uses a qualitative approach, with descriptive analysis method. The subjects of the study were 40 children from grades B1 and B2 and 8 teachers, and school principals at the KB TK Islam Al-Azhar 54 Pekanbaru, which were determined by the researchers by purposive sampling. The data analysis technique uses the interactive model from Milles and Huberman, through the stages of data collection, data reduction, data presentation, drawing conclusions and verification. The results of the research show the need for a conducive environment, interesting methods and media, adequate facilities and infrastructure, as well as teachers who are always creative and innovative. A strategy is needed so that the goals to be achieved can be more easily implemented. The implications of the strategies undertaken will help increase children's understanding of Malay culture, improve children's language skills, creativity and curiosity so that they become quality individuals in the future. The role of parents is also very large in fostering a sense of love for local culture, especially Malay Riau.
Wilayat Bint Alzina Fi An-nikah : Dirasat Bayn Alqanun Al'iindunisī Wal fiqh Al'īslamia
Authors: لباب ثابت فكري , مثوفين محمد احسان , حبيب حميدان
Published: March 2024

لقد اهتمت الشريعة الإسلامية في وجود الأسرة ومنها النكاح. والنكاح من أحد مقاصد الشريعة الإسلامية للحماية على بقاء كمال الدين والأعراض و الأموال و الأنساب.ولذلك قد شرح الدين عن بيان النكاح بشكل التام.من حيث شروطه و أركانه وغير ذلك ليكون النكاح على وجه الصحيح. ومسألة الزنا من أكبر المسائل في النكاح. ومن مسألة الزنا في النكاح تنسيب بنت الزنا.

        وهذا البحث بحث مكتبي ويعتمد المنهج الإستقرائي والتحليل المقارن, لقضية ولاية بنت الزنا في النكاح عند قانون الإندونيسي و الفقه الإسلامي. ومشكلة البحث تتكن من : 1. ما هي ولاية بنت الزنا في النكاح ؟ و ما القانون الإندونيسي و الفقه الإسلامي في ذلك ؟ 2. ما حكم ولاية بنت الزنا في النكاح في القانون الإندونيسي و الفقه الإسلامي ؟

        بعد البحث في القانون و الفقه الإسلامي أن بنت الزنا كغيرها من البنات الشرعيات في جميع الأحكام والحقوق إلا في قضية ولاية النكاح وما يتعلق بها. وقد أفرد الشريعة والحكومة على ذلك في أحكام خاصة تبين على ذلك. كما أن القانون الإندونيسي والفقه الإسلامي لم يستوفي حكم ولاية بنت الزنا بشكل تام.