bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress
Authors: Mullen Mary M. , Lomonosova Elena , Toboni Michael D. , Oplt Alyssa , Cybulla Emily , Blachut Barbara , Zhao Peinan , Noia Hollie , Wilke Daniel , Rankin Erinn B. , Kuroki Lindsay M. , Hagemann Andrea R. , Hagemann Ian S. , McCourt Carolyn K. , Thaker Premal H. , Mutch David G. , Powell Matthew A. , Mosammaparast Nima , Vindigni Alessandro , Fuh Katherine C.
Published: April 2023

Abstract
Over 80% of women with high-grade serous ovarian cancer (HGSOC) develop tumor resistance to chemotherapy and die of their disease. There are currently no FDA-approved agents to improve sensitivity to first-line platinum- and taxane-based chemotherapy or to PARP inhibitors. Here, we tested the hypothesis that expression of growth arrest–specific 6 (GAS6), the ligand of receptor tyrosine kinase AXL, is associated with chemotherapy response and that sequestration of GAS6 with AVB-S6–500 (AVB-500) could improve tumor response to chemotherapy and PARP inhibitors. We found that GAS6 levels in patient tumor and serum samples collected before chemotherapy correlated with ovarian cancer chemoresponse and patient survival. Compared with chemotherapy alone, AVB-500 plus carboplatin and/or paclitaxel led to decreased ovarian cancer-cell survival in vitro and tumor burden in vivo. Cells treated with AVB-500 plus carboplatin had more DNA damage, slower DNA replication fork progression, and fewer RAD51 foci than cells treated with carboplatin alone, indicating AVB-500 impaired homologous recombination (HR). Finally, treatment with the PARP inhibitor olaparib plus AVB-500 led to decreased ovarian cancer-cell survival in vitro and less tumor burden in vivo. Importantly, this effect was seen in HR-proficient and HR-deficient ovarian cancer cells. Collectively, our findings suggest that GAS6 levels could be used to predict response to carboplatin and AVB-500 could be used to treat platinum-resistant, HR-proficient HGSOC.
Implications:
GAS6/AXL is a novel target to sensitize ovarian cancers to carboplatin and olaparib. Additionally, GAS6 levels can be associated with response to carboplatin treatment.
Data from Phosphoproteomics Reveals the Role of Constitutive KAP1 Phosphorylation by B-cell Receptor Signaling in Chronic Lymphocytic Leukemia
Authors: Wu Jung-Lin , Wu Hsin-Yi , Wu Shang-Ju , Tsai Ho-Yang , Weng Shao-Hsing , Lin Kuen-Tyng , Lin Liang-In , Yao Chi-Yuan , Zamanova Margarita , Lee Yi-Yuan , Angata Takashi , Tien Hwei-Fang , Chen Yu-Ju , Lin Kuo-I
Published: April 2023

Abstract
Application of B-cell receptor (BCR) pathway inhibitor ibrutinib for chronic lymphocytic leukemia (CLL) is a major breakthrough, yet the downstream effects following inhibition of BCR signaling and during relapse await further clarification. By comparative phosphoproteomic profiling of B cells from patients with CLL and healthy donors, as well as CLL B cells collected at multiple time points during the course of ibrutinib treatment, we provided the landscape of dysregulated phosphoproteome in CLL and its dynamic alterations associated with ibrutinib treatment. Particularly, differential phosphorylation events associated with several signaling pathways, including BCR pathway, were enriched in patient CLL cells. A constitutively elevated phosphorylation level of KAP1 at serine 473 (S473) was found in the majority of CLL samples prior to treatment. Further verification showed that BCR activation promoted KAP1 S473 phosphorylation, whereas ibrutinib treatment abolished it. Depletion of KAP1 in primary CLL cells decelerated cell-cycle progression and ectopic expression of a KAP1 S473 phospho-mimicking mutant accelerated G2–M cell-cycle transition of CLL cells. Moreover, temporal phosphoproteomic profiles using a series of CLL cells isolated from one patient during the ibrutinib treatment revealed the dynamic changes of several molecules associated with BCR signaling in the ibrutinib responsive and recurrent stages.
Implications:
This phosphoproteomic analysis and functional validation illuminated the phosphorylation of KAP1 at S473 as an important downstream BCR signaling event and a potential indicator for the success of ibrutinib treatment in CLL.
Data from Glioblastoma–Astrocyte Connexin 43 Gap Junctions Promote Tumor Invasion
Authors: McCutcheon Sean , Spray David C.
Published: April 2023

Abstract
Glioblastoma multiforme (GBM), classified as World Health Organization grade IV astrocytoma, is the deadliest adult cancer of the central nervous system. An important contributing factor to poor survival rates in GBM is extensive invasion, which decreases the efficacy of resection and subsequent adjuvant therapies. These treatments could be markedly improved with increased resolution of the genetic and molecular initiators and effectors of invasion. Connexin 43 (Cx43) is the principal astrocytic gap junction (GJ) protein. Despite the heterogeneity of GBM, a subpopulation of cells in almost all GBM tumors express Cx43. Functional GJs between GBM cells and astrocytes at the tumor edge are of critical interest for understanding invasion. In this study, we find that both in vitro and in ex vivo slice cultures, GBM is substantially less invasive when placed in a Cx43-deficient astrocyte environment. Furthermore, when Cx43 is deleted in GBM, the invasive phenotype is recovered. These data strongly suggest that there are opposing roles for Cx43 in GBM migration. We find that Cx43 is localized to the tumor edge in our ex vivo model, suggesting that GBM–astrocyte GJ communication at the tumor border is a driving force for invasion. Finally, we find that by a Cx43-dependent mechanism, but likely not direct channel-mediated diffusion, miRNAs associated with cell–matrix adhesion are transferred from GBM to astrocytes and miR-19b promotes invasion, revealing a role for post-transcriptional manipulation of astrocytes in fostering an invasion-permissive peritumoral niche.
Implications:
Cx43-mediated communication, specifically miRNA transfer, profoundly impacts glioblastoma invasion and may enable further therapeutic insight.
Data from Molecular Profile Changes in Patients with Castrate-Resistant Prostate Cancer Pre- and Post-Abiraterone/Prednisone Treatment
Authors: Sicotte Hugues , Kalari Krishna R. , Qin Sisi , Dehm Scott M. , Bhargava Vipul , Gormley Michael , Tan Winston , Sinnwell Jason P. , Hillman David W. , Li Ying , Vedell Peter T. , Carlson Rachel E. , Bryce Alan H. , Jimenez Raphael E. , Weinshilboum Richard M. , Kohli Manish , Wang Liewei
Published: April 2023

Abstract
We identified resistance mechanisms to abiraterone acetate/prednisone (AA/P) in patients with metastatic castration-resistant prostate cancer (mCRPC) in the Prostate Cancer Medically Optimized Genome-Enhanced Therapy (PROMOTE) study.

We analyzed whole-exome sequencing (WES) and RNA-sequencing data from 83 patients with metastatic biopsies before (V1) and after 12 weeks of AA/P treatment (V2). Resistance was determined by time to treatment change (TTTC).

At V2, 18 and 11 of 58 patients had either short-term (median 3.6 months; range 1.4–4.5) or long-term (median 29 months; range 23.5–41.7) responses, respectively. Nonresponders had low expression of TGFBR3 and increased activation of the Wnt pathway, cell cycle, upregulation of AR variants, both pre- and posttreatment, with further deletion of AR inhibitor CDK11B posttreatment. Deletion of androgen processing genes, HSD17B11, CYP19A1 were observed in nonresponders posttreatment. Genes involved in cell cycle, DNA repair, Wnt-signaling, and Aurora kinase pathways were differentially expressed between the responder and non-responder at V2. Activation of Wnt signaling in nonresponder and deactivation of MYC or its target genes in responders was detected via SCN loss, somatic mutations, and transcriptomics. Upregulation of genes in the AURKA pathway are consistent with the activation of MYC regulated genes in nonresponders. Several genes in the AKT1 axis had increased mutation rate in nonresponders. We also found evidence of resistance via PDCD1 overexpression in responders.
Implications:
Finally, we identified candidates drugs to reverse AA/P resistance: topoisomerase inhibitors and drugs targeting the cell cycle via the MYC/AURKA/AURKB/TOP2A and/or PI3K_AKT_MTOR pathways.
Data from Midkine Promotes Metastasis and Therapeutic Resistance via mTOR/RPS6 in Uveal Melanoma
Authors: Karg Margarete M. , John Lukas , Refaian Nasrin , Buettner Christian , Rottmar Tanja , Sommer Jonas , Bock Barbara , Resheq Yazid J. , Ksander Bruce R. , Heindl Ludwig M. , Mackensen Andreas , Bosch Jacobus J.
Published: April 2023

Abstract
Uveal melanoma is a rare form of melanoma that originates in the eye, exerts widespread therapeutic resistance, and displays an inherent propensity for hepatic metastases. Because metastatic disease is characterized by poor survival, there is an unmet clinical need to identify new therapeutic targets in uveal melanoma. Here, we show that the pleiotropic cytokine midkine is expressed in uveal melanoma. Midkine expression in primary uveal melanoma significantly correlates with poor survival and is elevated in patients that develop metastatic disease. Monosomy 3 and histopathologic staging parameters are associated with midkine expression. In addition, we demonstrate that midkine promotes survival, migration across a barrier of hepatic sinusoid endothelial cells and resistance to AKT/mTOR inhibition. Furthermore, midkine is secreted and mediates mTOR activation by maintaining phosphorylation of the mTOR target RPS6 in uveal melanoma cells. Therefore, midkine is identified as a uveal melanoma cell survival factor that drives metastasis and therapeutic resistance, and could be exploited as a biomarker as well as a new therapeutic target.
Implications:
Midkine is identified as a survival factor that drives liver metastasis and therapeutic resistance in melanoma of the eye.
Data from Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells
Authors: Sun Lin , Wu Qian , Huan Xia-Juan , Tian Chang-Qing , Wang Ying-Qing , Miao Ze-Hong
Published: April 2023

Abstract
Inhibitors targeting bromodomain and extraterminal (BET) proteins are promising anticancer drugs. The emergence of drug resistance during treatments will impair their therapeutic effectiveness. To investigate the mechanisms of acquired resistance to BET inhibitors (BETi), we generated a series of drug-resistant sublines by exposing non–small cell lung cancer (NSCLC) NCI-H1975 cells to the BETi ABBV-075. These sublines displayed cross-resistance to other tested BETis, increased migration abilities, reduced growth rates accompanied by an increased proportion of cells in G1 phase and decreased apoptotic responses to BETis. Changes in RNA expression and gene mutation profiles in the resistant variants indicate that emergence of BETi resistance is multifactorial. Importantly, all the tested ABBV-075–resistant variants showed loss of vesicular overexpressed in cancer prosurvival protein 1 (VOPP1) and an increase in the antiapoptotic BCL-2 protein. By knockdown, knockout, and reconstitution of VOPP1 in resistant cells, their parental cells, and other NSCLC cells, we confirmed that the loss of VOPP1 contributed to BETi resistance. Moreover, knockout of VOPP1 in the parental cells caused the increased expression of BCL-2, and the latter directly mediated BETi resistance. Through combined treatments with BETis and BCL-2 inhibitors (BCL-2i), we demonstrated that BCL-2is synergistically sensitized resistant cells to BETis.
Implications:
Based on these results, for the first time, we establish a causal link from VOPP1 loss to BCL-2 gain and then to BETi resistance, which provides new insights into BETi resistance and paves the way for further testing to circumvent BETi resistance.
Data from TFAP4 Activates IGF2BP1 and Promotes Progression of Non–Small Cell Lung Cancer by Stabilizing TK1 Expression through m6A Modification
Authors: Shen Qiming , Xu Zhe , Sun Guanghao , Wang Haoyou , Zhang Lin
Published: April 2023

Abstract
Non–small cell lung cancer (NSCLC) is a well-known global health concern. TFAP4 has been reported to function as an oncogene. This study sought to investigate the molecular mechanism of TFAP4 in NSCLC development. Significantly highly-expressed gene IGF2BP1 was screened on online databases and its downstream gene TK1 was predicted. IGF2BP1 promoter sequence was identified. The binding site of TFAP4 and IGF2BP1 was predicted. The expression correlations among TFAP4, IGF2BP1, and TK1 were confirmed. The correlations between TFAP4, IGF2BP1, TK1, and NSCLC prognosis were predicted. NSCLC and paracancerous tissues were collected. The expressions of TFAP4, IGF2BP1, and TK1 were detected. NSCLC cell proliferation, migration, invasion, and apoptosis were detected. The binding of TFAP4 to the IGF2BP1 promoter was verified. m6A modification of TK1 mRNA was detected. The correlation between IGF2BP1 and TK1 was confirmed. A subcutaneous tumor xenograft model was established to validate the effect of TFAP4 in vivo. IGF2BP1 was highly expressed in NSCLC tissues and cells. IGF2BP1 knockdown repressed NSCLC cell proliferation, migration, and invasion and facilitated apoptosis. Mechanically, TFAP4 transcriptionally activated IGF2BP1. IGF2BP1 stabilized TK1 expression via m6A modification and promoted NSCLC cell proliferation, migration, and invasion. In vivo experiments confirmed that TFAP4 knockdown suppressed tumor growth by downregulating IGF2BP1/TK1.
Implications:
Our findings revealed that TFAP4 activated IGF2BP1 and facilitated NSCLC progression by stabilizing TK1 expression via m6A modification, which offered new insights into the diagnosis and treatment of NSCLC.
Supplementary Material from Effect of Chronic and Intermittent Calorie Restriction on Serum Adiponectin and Leptin and Mammary Tumorigenesis
Authors: Rogozina Olga P. , Bonorden Melissa J.L. , Seppanen Christine N. , Grande Joseph P. , Cleary Margot P.
Published: April 2023

Supplementary Material from Effect of Chronic and Intermittent Calorie Restriction on Serum Adiponectin and Leptin and Mammary Tumorigenesis
Supplementary Figure 1 from Programmable Bio-Nano-Chip Systems for Serum CA125 Quantification: Toward Ovarian Cancer Diagnostics at the Point-of-Care
Authors: Raamanathan Archana , Simmons Glennon W. , Christodoulides Nicolaos , Floriano Pierre N. , Furmaga Wieslaw B. , Redding Spencer W. , Lu Karen H. , Bast Robert C. , McDevitt John T.
Published: April 2023

PDF file - 19K, Representative linear calibration curve (0-50 U/mL range highlighted for clarity
Supplementary Table 1 from Failure Rates in the Hepatocellular Carcinoma Surveillance Process
Authors: Singal Amit G. , Yopp Adam C. , Gupta Samir , Skinner Celette Sugg , Halm Ethan A. , Okolo Eucharia , Nehra Mahendra , Lee William M. , Marrero Jorge A. , Tiro Jasmin A.
Published: April 2023

DOC file, 30K, Definitions for Categories of Process Failures.
Supplementary Materials 2 from Identification of Modulated Genes by Three Classes of Chemopreventive Agents at Preneoplastic Stages in a p53-Null Mouse Mammary Tumor Model
Authors: Abba Martín C. , Hu Yuhui , Levy Carla C. , Gaddis Sally , Kittrell Frances S. , Hill Jamal , Bissonnette Reid P. , Brown Powel H. , Medina Daniel , Aldaz C. Marcelo
Published: April 2023

Supplementary Materials 2 from Identification of Modulated Genes by Three Classes of Chemopreventive Agents at Preneoplastic Stages in a p53-Null Mouse Mammary Tumor Model
Perspective from Effects of Tobacco Smoke on Gene Expression and Cellular Pathways in a Cellular Model of Oral Leukoplakia
Authors: Gümüş Zeynep H. , Du Baoheng , Kacker Ashutosh , Boyle Jay O. , Bocker Jennifer M. , Mukherjee Piali , Subbaramaiah Kotha , Dannenberg Andrew J. , Weinstein Harel
Published: April 2023

Perspective from Effects of Tobacco Smoke on Gene Expression and Cellular Pathways in a Cellular Model of Oral Leukoplakia
Perspective on This Article from Loss of Heterozygosity (LOH) Profiles—Validated Risk Predictors for Progression to Oral Cancer
Authors: Zhang Lewei , Poh Catherine F. , Williams Michele , Laronde Denise M. , Berean Ken , Gardner Pamela J. , Jiang Huijun , Wu Lang , Lee J. Jack , Rosin Miriam P.
Published: April 2023

Perspective on This Article from Loss of Heterozygosity (LOH) Profiles—Validated Risk Predictors for Progression to Oral Cancer
Supplementary Figures S1 and S2 from A Mouse Model for Human Anal Cancer
Authors: Stelzer Marie K. , Pitot Henry C. , Liem Amy , Schweizer Johannes , Mahoney Charles , Lambert Paul F.
Published: April 2023

Supplementary Figures S1 and S2 from A Mouse Model for Human Anal Cancer
Supplementary Figure Legend from Effect of Intermittent Dosing Regimens of Erlotinib on Methylnitrosourea-Induced Mammary Carcinogenesis
Authors: Lubet Ronald A. , Szabo Eva , Iwata Kenneth K. , Gill Stanley C. , Tucker Chris , Bode Ann , Steele Vernon E. , Juliana M. Margaret , Nicastro Holly L. , Grubbs Clinton J.
Published: April 2023

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Perspective on this Article from Phase II Randomized, Placebo-Controlled Trial of Green Tea Extract in Patients with High-Risk Oral Premalignant Lesions
Authors: Tsao Anne S. , Liu Diane , Martin Jack , Tang Xi-ming , Lee J. Jack , El-Naggar Adel K. , Wistuba Ignacio , Culotta Kirk S. , Mao Li , Gillenwater Ann , Sagesaka Yuko M. , Hong Waun K. , Papadimitrakopoulou Vassiliki
Published: April 2023

Perspective on this Article from Phase II Randomized, Placebo-Controlled Trial of Green Tea Extract in Patients with High-Risk Oral Premalignant Lesions
Perspective on this Article from Longitudinal Assessment of Air Conduction Audiograms in a Phase III Clinical Trial of Difluoromethylornithine and Sulindac for Prevention of Sporadic Colorectal Adenomas
Authors: McLaren Christine E. , Fujikawa-Brooks Sharon , Chen Wen-Pin , Gillen Daniel L. , Pelot Daniel , Gerner Eugene W. , Meyskens Frank L.
Published: April 2023

Perspective on this Article from Longitudinal Assessment of Air Conduction Audiograms in a Phase III Clinical Trial of Difluoromethylornithine and Sulindac for Prevention of Sporadic Colorectal Adenomas
Perspective on this Article from Chromoendoscopy Detects More Adenomas than Colonoscopy Using Intensive Inspection without Dye Spraying
Authors: Stoffel Elena M. , Turgeon D. Kim , Stockwell David H. , Normolle Daniel P. , Tuck Missy K. , Marcon Norman E. , Baron John A. , Bresalier Robert S. , Arber Nadir , Ruffin Mack T. , Syngal Sapna , Brenner Dean E.
Published: April 2023

Perspective on this Article from Chromoendoscopy Detects More Adenomas than Colonoscopy Using Intensive Inspection without Dye Spraying
Supplementary Table 1 from Constitutive Short Telomere Length of Chromosome 17p and 12q but not 11q and 2p Is Associated with an Increased Risk for Esophageal Cancer
Authors: Xing Jinliang , Ajani Jaffer A. , Chen Meng , Izzo Julie , Lin Jie , Chen Zhinan , Gu Jian , Wu Xifeng
Published: April 2023

Supplementary Table 1 from Constitutive Short Telomere Length of Chromosome 17p and 12q but not 11q and 2p Is Associated with an Increased Risk for Esophageal Cancer
Supplementary Figures 1 - 3 from Erb-041, an Estrogen Receptor-β Agonist, Inhibits Skin Photocarcinogenesis in SKH-1 Hairless Mice by Downregulating the WNT Signaling Pathway
Authors: Chaudhary Sandeep C. , Singh Tripti , Talwelkar Sarang S. , Srivastava Ritesh K. , Arumugam Aadithya , Weng Zhiping , Elmets Craig A. , Afaq Farrukh , Kopelovich Levy , Athar Mohammad
Published: April 2023

PDF file - 1105K, Supplemental Figure S1: Effect of Erb-041 treatment on UVB-induced skin tumorigenesis in SKH-1 hairless mice. Supplemental Figure S2: Bar diagram showing effect of Erb-041 on UVB-mediated alteration in inflammation and EMT regulatory proteins. Supplemental Figure S3: Alterations in AKT and WNT signaling proteins in UVB-induced SCCs in vehicle or Erb-041 treated mice.
Supplementary Table 1 from Phase II Prospective Randomized Trial of a Low-Fat Diet with Fish Oil Supplementation in Men Undergoing Radical Prostatectomy
Authors: Aronson William J. , Kobayashi Naoko , Barnard R. James , Henning Susanne , Huang Min , Jardack Patricia M. , Liu Bingrong , Gray Ashley , Wan Junxiang , Konijeti Ramdev , Freedland Stephen J. , Castor Brandon , Heber David , Elashoff David , Said Jonathan , Cohen Pinchas , Galet Colette
Published: April 2023

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Supplementary Figure Legend from Acacetin Inhibits In Vitro and In Vivo Angiogenesis and Downregulates Stat Signaling and VEGF Expression
Authors: Bhat Tariq A. , Nambiar Dhanya , Tailor Dhanir , Pal Arttatrana , Agarwal Rajesh , Singh Rana P.
Published: April 2023

PDF - 68K, Figure legend for Supplementary Figure 1.
Supplementary Table 4 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Authors: Beane Jennifer , Vick Jessica , Schembri Frank , Anderlind Christina , Gower Adam , Campbell Joshua , Luo Lingqi , Zhang Xiao Hui , Xiao Ji , Alekseyev Yuriy O. , Wang Shenglong , Levy Shawn , Massion Pierre P. , Lenburg Marc , Spira Avrum
Published: April 2023

Supplementary Table 4 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Table 3 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Authors: Beane Jennifer , Vick Jessica , Schembri Frank , Anderlind Christina , Gower Adam , Campbell Joshua , Luo Lingqi , Zhang Xiao Hui , Xiao Ji , Alekseyev Yuriy O. , Wang Shenglong , Levy Shawn , Massion Pierre P. , Lenburg Marc , Spira Avrum
Published: April 2023

Supplementary Table 3 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Table 2 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Authors: Beane Jennifer , Vick Jessica , Schembri Frank , Anderlind Christina , Gower Adam , Campbell Joshua , Luo Lingqi , Zhang Xiao Hui , Xiao Ji , Alekseyev Yuriy O. , Wang Shenglong , Levy Shawn , Massion Pierre P. , Lenburg Marc , Spira Avrum
Published: April 2023

Supplementary Table 2 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Table 10 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Authors: Beane Jennifer , Vick Jessica , Schembri Frank , Anderlind Christina , Gower Adam , Campbell Joshua , Luo Lingqi , Zhang Xiao Hui , Xiao Ji , Alekseyev Yuriy O. , Wang Shenglong , Levy Shawn , Massion Pierre P. , Lenburg Marc , Spira Avrum
Published: April 2023

Supplementary Table 10 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Table 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Authors: Beane Jennifer , Vick Jessica , Schembri Frank , Anderlind Christina , Gower Adam , Campbell Joshua , Luo Lingqi , Zhang Xiao Hui , Xiao Ji , Alekseyev Yuriy O. , Wang Shenglong , Levy Shawn , Massion Pierre P. , Lenburg Marc , Spira Avrum
Published: April 2023

Supplementary Table 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Figure 2 from Dietary Resveratrol Prevents Development of High-Grade Prostatic Intraepithelial Neoplastic Lesions: Involvement of SIRT1/S6K Axis
Authors: Li Guiming , Rivas Paul , Bedolla Roble , Thapa Dinesh , Reddick Robert L. , Ghosh Rita , Kumar Addanki P.
Published: April 2023

PDF file - 60KB, Apoptosis in SIRT1 knockdown DU145 cells
Data Supplement from The Antidepressant Desipramine and α2-Adrenergic Receptor Activation Promote Breast Tumor Progression in Association with Altered Collagen Structure
Authors: Szpunar Mercedes J. , Burke Kathleen A. , Dawes Ryan P. , Brown Edward B. , Madden Kelley S.
Published: April 2023

Supplemental Fig. S1. 4T1 Cells Do Not Express Functional a2-AR. High dose DEX-induced effects on 4T1 (A) proliferation and (B) VEGF production in vitro are not blocked by the a2-AR antagonist yohimbine (YOH). (C) The alpha2-AR agonists clonidine (CLON) and dexmedetomidine (DEX) do not inhibit forskolin (FORSK)-induced cAMP in 4T1 cells. (D) CLON and DEX reduced FORSK-induced cAMP in human foreskin fibroblasts (HFF). Groups labeled with same letter are not significantly different from each other, but are significantly different from groups labeled with different letters, p{less than or equal to}0.01, Tukey's post-hoc test. Supplemental Fig. S2. DMI Elevates Spleen Norepinephrine (NE) and the NE Metabolite, Normetanephrine (NMN). Spleen (A) NE and (B) NMN were increased 3 days post-DMI pellet implantation. (C) Spleen weight was decreased day 3 post-DMI implantation. *** indicates significant differences versus corresponding placebo group, Holm-Sidak multiple comparison test, p<0.001. Supplemental Fig. S3. DMI-induced Tumor Growth is Not Associated with Altered Tumor Angiogenesis. Immunocytochemical staining of CD31+ blood vessels in tumor slices were quantified by two different methods: (A) percentage of pixels above threshold and (B) calculating the area of traced vessels per cell density based on nuclear DAPI staining (not shown). (C) A representative image of CD31+ blood vessels. Scale bar = 50 µm. Supplemental Fig. S4. TNF-a Does Not Induce 4T1 Proliferation in Vitro. Results are expressed as mean {plus minus} SD of triplicate wells. Supplemental Fig. S5. Tumor F4/80+ Macrophage Density Is Not Significantly Changed with A) DMI or B) DEX treatment. (C) Representative image of F4/80+ macrophages in a 4T1 tumor section by immunofluorescence; scale bar = 100 µm. Statistical analysis by Mann-Whitney (M-W) nonparametric test.
Supplementary Figure 1 from Methylselenocysteine Resets the Rhythmic Expression of Circadian and Growth-Regulatory Genes Disrupted by Nitrosomethylurea In vivo
Authors: Fang Ming Zhu , Zhang Xun , Zarbl Helmut
Published: April 2023

Supplementary Figure 1 from Methylselenocysteine Resets the Rhythmic Expression of Circadian and Growth-Regulatory Genes Disrupted by Nitrosomethylurea In vivo
Supplementary Legends for Figures and Video from Multiphoton Tomographic Imaging: A Potential Optical Biopsy Tool for Detecting Gastrointestinal Inflammation and Neoplasia
Authors: Makino Tomoki , Jain Manu , Montrose David C. , Aggarwal Amit , Sterling Joshua , Bosworth Brian P. , Milsom Jeffrey W. , Robinson Brian D. , Shevchuk Maria M. , Kawaguchi Kathy , Zhang Ning , Brown Christopher M. , Rivera David R. , Williams Wendy O. , Xu Chris , Dannenberg Andrew J. , Mukherjee Sushmita
Published: April 2023

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Supplementary Figures 1-2 from Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage
Authors: Algire Carolyn , Moiseeva Olga , Deschênes-Simard Xavier , Amrein Lilian , Petruccelli Luca , Birman Elena , Viollet Benoit , Ferbeyre Gerardo , Pollak Michael N.
Published: April 2023

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Supplementary Figure 2 from Is There a Link Between Genome-Wide Hypomethylation in Blood and Cancer Risk?
Authors: Brennan Kevin , Flanagan James M.
Published: April 2023

PDF file - 52K, Meta-analysis of LINE1
Supplementary Tables 1-3 from Association between Serum Phospholipid Fatty Acids and Intraprostatic Inflammation in the Placebo Arm of the Prostate Cancer Prevention Trial
Authors: Nash Sarah H. , Schenk Jeannette M. , Kristal Alan R. , Goodman Phillis J. , Lucia M. Scott , Parnes Howard L. , Thompson Ian M. , Lippman Scott M. , Song Xiaoling , Gurel Bora , De Marzo Angelo , Platz Elizabeth A.
Published: April 2023

Supplementary Tables 1-3. Supplementary Table 1. Characteristics1 of cases2 with and without inflammation in prostate biopsy cores, in the placebo arm of the Prostate Cancer Prevention Trial. Supplementary Table 2. Distribution of serum phospholipid fatty acids by percent of total among cases with and without inflammation in prostate biopsy cores, in the placebo arm of the Prostate Cancer Prevention Trial. Supplementary Table 3. Multivariable-adjusted associations of serum phospholipid fatty acids in relation to inflammation in prostate biopsy cores, among cases from the placebo arm of the Prostate Cancer Prevention Trial.
Supplementary Table 2 from A Hexane Fraction of American Ginseng Suppresses Mouse Colitis and Associated Colon Cancer: Anti-inflammatory and Proapoptotic Mechanisms
Authors: Poudyal Deepak , Mai Le Phuong , Davis Tia , Hofseth Anne B. , Chumanevich Alena , Chumanevich Alexander A. , Wargovich Michael J. , Nagarkatti Mitzi , Nagarkatti Prakash S. , Windust Anthony , Hofseth Lorne J.
Published: April 2023

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Supplementary Figure 2 cont. from Transcriptional Attenuation in Colon Carcinoma Cells in Response to Butyrate
Authors: Daroqui Maria C. , Augenlicht Leonard H.
Published: April 2023

Supplementary Figure 2 cont. from Transcriptional Attenuation in Colon Carcinoma Cells in Response to Butyrate
Supplementary Figure 1 from Transcriptional Attenuation in Colon Carcinoma Cells in Response to Butyrate
Authors: Daroqui Maria C. , Augenlicht Leonard H.
Published: April 2023

Supplementary Figure 1 from Transcriptional Attenuation in Colon Carcinoma Cells in Response to Butyrate
Supplementary Figure 6 from A Hexane Fraction of American Ginseng Suppresses Mouse Colitis and Associated Colon Cancer: Anti-inflammatory and Proapoptotic Mechanisms
Authors: Poudyal Deepak , Mai Le Phuong , Davis Tia , Hofseth Anne B. , Chumanevich Alena , Chumanevich Alexander A. , Wargovich Michael J. , Nagarkatti Mitzi , Nagarkatti Prakash S. , Windust Anthony , Hofseth Lorne J.
Published: April 2023

PDF file - 1.2MB, Expression of apoptotic markers in TK6 cells following exposure to the Hexane Fraction of AG. TK6 cells were exposed to 200 �g/ml of the Hexane Fraction of AG for indicated time points. Western blot was carried out for analysis of full length PARP, cleaved PARP p53, Phospho-p53-Serine-15, Wip1, PUMA, and β-actin as indicated. Numbers under the bands indicate densitometry values as a ratio relative to control (time 0 hr) for each treatment.
Supplementary Figure 2 from A Hexane Fraction of American Ginseng Suppresses Mouse Colitis and Associated Colon Cancer: Anti-inflammatory and Proapoptotic Mechanisms
Authors: Poudyal Deepak , Mai Le Phuong , Davis Tia , Hofseth Anne B. , Chumanevich Alena , Chumanevich Alexander A. , Wargovich Michael J. , Nagarkatti Mitzi , Nagarkatti Prakash S. , Windust Anthony , Hofseth Lorne J.
Published: April 2023

PDF file - 501K, Experimental protocol for the AOM/DSS mouse model of colon cancer associated with colitis. 11.9 mg/kg/day of whole AG extract, the Hexane Fraction of AG or Vehicle (1x PBS) was given to the respective group of mice by oral gavage after a single injection of AOM (10 mg/kg) and 1 week of 1% DSS. The mice from each group were euthanized on days indicated.
Supplementary Video 1a from In Vivo Longitudinal Imaging of Experimental Human Papillomavirus Infection in Mice with a Multicolor Fluorescence Mini-Endoscopy System
Authors: Mitsunaga Makoto , Kosaka Nobuyuki , Kines Rhonda C. , Roberts Jeffrey N. , Lowy Douglas R. , Schiller John T. , Ishihara Yasushige , Hasegawa Akira , Choyke Peter L. , Kobayashi Hisataka
Published: April 2023

Supplementary Video 1a from In Vivo Longitudinal Imaging of Experimental Human Papillomavirus Infection in Mice with a Multicolor Fluorescence Mini-Endoscopy System
Supplementary Table 1 from Simple Clinical Risk Score Identifies Patients with Serrated Polyps in Routine Practice
Authors: Bouwens Mariëlle W.E. , Winkens Bjorn , Rondagh Eveline J.A. , Driessen Ann L. , Riedl Robert G. , Masclee Ad A.M. , Sanduleanu Silvia
Published: April 2023

PDF - 59K, Individual detection rates of greater than or equal to 1 large, proximal or dysplastic (LPD) serrated polyp (SP) among the 8 gastroenterologist and 6 trainees included in the derivation cohort.
Related Article from DNA Methylation Markers for Prostate Cancer with a Stem Cell Twist
Authors: Jerónimo Carmen , Esteller Manel
Published: April 2023

Related Article from DNA Methylation Markers for Prostate Cancer with a Stem Cell Twist
Supplementary Tables 1-4 from DNA Methylation Biomarkers for Noninvasive Diagnosis of Colorectal Cancer
Authors: Carmona F. Javier , Azuara Daniel , Berenguer-Llergo Antonio , Fernández Agustin F. , Biondo Sebastiano , de Oca Javier , Rodriguez-Moranta Francisco , Salazar Ramón , Villanueva Alberto , Fraga Mario F. , Guardiola Jordi , Capellá Gabriel , Esteller Manel , Moreno Victor
Published: April 2023

PDF File - 100K, Pyrosequencing primers used to quantify the methylation status of selected CG sites.
Supplementary Figures 1-6 from DNA Methylation Biomarkers for Noninvasive Diagnosis of Colorectal Cancer
Authors: Carmona F. Javier , Azuara Daniel , Berenguer-Llergo Antonio , Fernández Agustin F. , Biondo Sebastiano , de Oca Javier , Rodriguez-Moranta Francisco , Salazar Ramón , Villanueva Alberto , Fraga Mario F. , Guardiola Jordi , Capellá Gabriel , Esteller Manel , Moreno Victor
Published: April 2023

PDF File - 916K, Representative pyrograms in a healthy colonic mucosa sample for the markers analyzed.
Supplementary Data from Grape Seeds: Ripe for Cancer Chemoprevention
Authors: Katiyar Santosh K. , Athar Mohammad
Published: April 2023

Supplementary Data from Grape Seeds: Ripe for Cancer Chemoprevention
Supplementary Table 1 from Associations between Oral HPV16 Infection and Cytopathology: Evaluation of an Oropharyngeal “Pap-Test Equivalent” in High-Risk Populations
Authors: Fakhry Carole , Rosenthal Barbara T. , Clark Douglas P. , Gillison Maura L.
Published: April 2023

PDF file - 54K
Supplementary Video 1 from eRapa Restores a Normal Life Span in a FAP Mouse Model
Authors: Hasty Paul , Livi Carolina B. , Dodds Sherry G. , Jones Diane , Strong Randy , Javors Martin , Fischer Kathleen E. , Sloane Lauren , Murthy Kruthi , Hubbard Gene , Sun Lishi , Hurez Vincent , Curiel Tyler J. , Sharp Zelton Dave
Published: April 2023

MOV file - 3205K, Three ApcMIn/+ 42 ppm eRapa-fed female mice at 902 days of age.
Supplementary Tables 1 - 6 from PI3K-AKT Signaling Is a Downstream Effector of Retinoid Prevention of Murine Basal Cell Carcinogenesis
Authors: So Po-Lin , Wang Grace Y. , Wang Kevin , Chuang Mindy , Chiueh Venice Calinisan , Kenny Paraic A. , Epstein Ervin H.
Published: April 2023

PDF file - 117K, Supplemental Table S1. A list of the top 30 DE gene probes (including replicates) upregulated after 10 h of tazarotene treatment as analyzed using the Bioconductor software (* p < 0.05). Supplemental Table S2. A list of the top 30 DE gene probes (including replicates) downregulated after 10 h of tazarotene treatment as analyzed using the Bioconductor software (* p < 0.05). Supplemental Table S3. A list of the top 30 DE gene probes (including replicates) upregulated after 24 h of tazarotene treatment as analyzed using the Bioconductor software (* p < 0.05). Supplemental Table S4. A list of the top 30 DE gene probes (including replicates) downregulated after 24 h of tazarotene treatment as analyzed using the Bioconductor software (* p < 0.05). Supplemental Table S5.Functional clustering (using the Ingenuity software) of the Bioconductor list of 24 h DE genes affected by tazarotene treatment suggested that a large number of the DE genes were associated significantly with three key processes (* p < 0.0001). Supplemental Table S6. The top canonical pathways suggested by bioinformatic clustering of the Bioconductor list of 24 h DE genes affected by tazarotene treatment (using the Ingenuity software), were cell cycle and metabolism processes (* p < 0.0001).
Related Articles / Press Coverage from Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
Authors: Pollak Michael
Published: April 2023

Related Articles / Press Coverage from Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
Supplementary Figure 3 from Dietary Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine–Induced Prostate Carcinogenesis in CYP1A-Humanized Mice
Authors: Li Guangxun , Wang Hong , Liu Anna B. , Cheung Connie , Reuhl Kenneth R. , Bosland Maarten C. , Yang Chung S.
Published: April 2023

PDF file - 153K, The increase of methylated CpG islands in Cdh1 (E-cadherin) and Gstp1/2 genes in prostates bearing the PhIP-induced adenocarinoma
Supplementary Table S6 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
Authors: Wong Ee Ming , Southey Melissa C. , Fox Stephen B. , Brown Melissa A. , Dowty James G. , Jenkins Mark A. , Giles Graham G. , Hopper John L. , Dobrovic Alexander
Published: April 2023

Supplementary Table S6 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S5 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
Authors: Wong Ee Ming , Southey Melissa C. , Fox Stephen B. , Brown Melissa A. , Dowty James G. , Jenkins Mark A. , Giles Graham G. , Hopper John L. , Dobrovic Alexander
Published: April 2023

Supplementary Table S5 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S2 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
Authors: Wong Ee Ming , Southey Melissa C. , Fox Stephen B. , Brown Melissa A. , Dowty James G. , Jenkins Mark A. , Giles Graham G. , Hopper John L. , Dobrovic Alexander
Published: April 2023

Supplementary Table S2 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table 3 from Characterizing the Molecular Spatial and Temporal Field of Injury in Early-Stage Smoker Non–Small Cell Lung Cancer Patients after Definitive Surgery by Expression Profiling
Authors: Kadara Humam , Shen Li , Fujimoto Junya , Saintigny Pierre , Chow Chi-Wan , Lang Wenhua , Chu Zuoming , Garcia Melinda , Kabbout Mohamed , Fan You-Hong , Behrens Carmen , Liu Diane A. , Mao Li , Lee J. Jack , Gold Kathryn A. , Wang Jing , Coombes Kevin R. , Kim Edward S. , Hong Waun Ki , Wistuba Ignacio I.
Published: April 2023

XLSX file - 627K, Supplementary table depicting 1395 genes significantly differentially expressed with time in the molecular field of injury
Supplementary Materials from Neonatal Experiences Differentially Influence Mammary Gland Morphology, Estrogen Receptor α Protein Levels, and Carcinogenesis in BALB/c Mice
Authors: Boyd Allison L. , Salleh Ayesha , Humber Brent , Yee Janet , Tomes Ladislav , Kerr Leslie R.
Published: April 2023

Supplementary Materials from Neonatal Experiences Differentially Influence Mammary Gland Morphology, Estrogen Receptor α Protein Levels, and Carcinogenesis in BALB/c Mice
Supplementary Table 6 from Molecular Profiling of Premalignant Lesions in Lung Squamous Cell Carcinomas Identifies Mechanisms Involved in Stepwise Carcinogenesis
Authors: Ooi Aik T. , Gower Adam C. , Zhang Kelvin X. , Vick Jessica L. , Hong Longsheng , Nagao Brian , Wallace W. Dean , Elashoff David A. , Walser Tonya C. , Dubinett Steven M. , Pellegrini Matteo , Lenburg Marc E. , Spira Avrum , Gomperts Brigitte N.
Published: April 2023

XLS file - 35KB, TP53 activity prediction and its target genes.
Related Article from The Origins and Implications of Intratumor Heterogeneity
Authors: Michor Franziska , Polyak Kornelia
Published: April 2023

Related Article from The Origins and Implications of Intratumor Heterogeneity
Supplementary Figure 1 from Targeting FACT Complex Suppresses Mammary Tumorigenesis in Her2/neu Transgenic Mice
Authors: Koman Igor E. , Commane Mairead , Paszkiewicz Geraldine , Hoonjan Bhupinder , Pal Srabani , Safina Alfiya , Toshkov Ilya , Purmal Andrei A. , Wang Dan , Liu Song , Morrison Carl , Gudkov Andrei V. , Gurova Katerina V.
Published: April 2023

PDF file - 790K, Absence of morphological changes in organs of MMTV-neu mice treated with Curaxin-137 from 4 to 14 weeks of age.
Perspective on this Article from The Detection of Chromosomal Aneusomy by Fluorescence In situ Hybridization in Sputum Predicts Lung Cancer Incidence
Authors: Varella-Garcia Marileila , Schulte Aline P. , Wolf Holly J. , Feser William J. , Zeng Chan , Braudrick Sarah , Yin Xiang , Hirsch Fred R. , Kennedy Timothy C. , Keith Robert L. , Barón Anna E. , Belinsky Steven A. , Miller York E. , Byers Tim , Franklin Wilbur A.
Published: April 2023

Perspective on this Article from The Detection of Chromosomal Aneusomy by Fluorescence In situ Hybridization in Sputum Predicts Lung Cancer Incidence
Supplementary Table 2 from microRNA Portraits in Human Vulvar Carcinoma
Authors: de Melo Maia Beatriz , Lavorato-Rocha André Mourão , Rodrigues Lara Sant'Ana , Coutinho-Camillo Cláudia Malheiros , Baiocchi Glauco , Stiepcich Monica Maria , Puga Renato , de A. Lima Leandro , Soares Fernando Augusto , Rocha Rafael Malagoli
Published: April 2023

PDF file - 66K, Describes the putative target mRNA validation
Supplementary Figure S2 from Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia
Authors: Carroll Robert E. , Benya Richard V. , Turgeon Danielle Kim , Vareed Shaiju , Neuman Malloree , Rodriguez Luz , Kakarala Madhuri , Carpenter Philip M. , McLaren Christine , Meyskens Frank L. , Brenner Dean E.
Published: April 2023

Supplementary Figure S2 from Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia
Supplementary Table 2 from Prediction of Recurrence and Survival in Hepatocellular Carcinoma Based on Two Cox Models Mainly Determined by FoxP3+ Regulatory T Cells
Authors: Lin Sheng-Zhang , Chen Kang-Jie , Xu Zhi-Yuan , Chen Hui , Zhou Lin , Xie Hai-Yang , Zheng Shu-Sen
Published: April 2023

PDF file - 57K, Primers for real-time PCR.
Supplementary Table 1 from Metabolic Profiling, a Noninvasive Approach for the Detection of Experimental Colorectal Neoplasia
Authors: Montrose David C. , Zhou Xi Kathy , Kopelovich Levy , Yantiss Rhonda K. , Karoly Edward D. , Subbaramaiah Kotha , Dannenberg Andrew J.
Published: April 2023

PDF file - 39K, Gene expression levels were determined in tumor tissue and normal colorectal mucosa by quantitative real-time PCR.
Supplementary Table S1 from Dietary Tomato and Lycopene Impact Androgen Signaling- and Carcinogenesis-Related Gene Expression during Early TRAMP Prostate Carcinogenesis
Authors: Wan Lei , Tan Hsueh-Li , Thomas-Ahner Jennifer M. , Pearl Dennis K. , Erdman John W. , Moran Nancy E. , Clinton Steven K.
Published: April 2023

Supplementary Table S1. Murine prostatic carcinogenesis gene codeset gene list
Perspective on This Article from The Epidermal Growth Factor Receptor Inhibitor Gefitinib Prevents the Progression of Pancreatic Lesions to Carcinoma in a Conditional LSL-KrasG12D/+ Transgenic Mouse Model
Authors: Mohammed Altaf , Janakiram Naveena B. , Li Qian , Madka Venkateshwar , Ely Misty , Lightfoot Stan , Crawford Howard , Steele Vernon E. , Rao Chinthalapally V.
Published: April 2023

Perspective on This Article from The Epidermal Growth Factor Receptor Inhibitor Gefitinib Prevents the Progression of Pancreatic Lesions to Carcinoma in a Conditional LSL-KrasG12D/+ Transgenic Mouse Model
Supplementary Figure Legend from Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study
Authors: Raina Komal , Ravichandran Kameswaran , Rajamanickam Subapriya , Huber Kendra M. , Serkova Natalie J. , Agarwal Rajesh
Published: April 2023

PDF file - 52K
Supplementary Figure 1 from An MLH1 Mutation Links BACH1/FANCJ to Colon Cancer, Signaling, and Insight toward Directed Therapy
Authors: Xie Jenny , Guillemette Shawna , Peng Min , Gilbert Candace , Buermeyer Andrew , Cantor Sharon B.
Published: April 2023

Supplementary Figure 1 from An MLH1 Mutation Links BACH1/FANCJ to Colon Cancer, Signaling, and Insight toward Directed Therapy
Supplementary Figure 6 from Increased Plasma Levels of the APC-Interacting Protein MAPRE1, LRG1, and IGFBP2 Preceding a Diagnosis of Colorectal Cancer in Women
Authors: Ladd Jon J. , Busald Tina , Johnson Melissa M. , Zhang Qing , Pitteri Sharon J. , Wang Hong , Brenner Dean E. , Lampe Paul D. , Kucherlapati Raju , Feng Ziding , Prentice Ross L. , Hanash Samir M.
Published: April 2023

PDF file - 117K, ELISA data for individual markers in newly diagnosed samples separated by gender. Only significant differences are demarcated. * indicates p<0.05, ** indicates p<0.01, *** indicates p<0.001.
Supplemental Figure 1 from Kaempferol Targets RSK2 and MSK1 to Suppress UV Radiation-Induced Skin Cancer
Authors: Yao Ke , Chen Hanyong , Liu Kangdong , Langfald Alyssa , Yang Ge , Zhang Yi , Yu Dong Hoon , Kim Myoung Ok , Lee Mee-Hyun , Li Haitao , Bae Ki Beom , Kim Hong-Gyum , Ma Wei-Ya , Bode Ann M. , Dong Ziming , Dong Zigang
Published: April 2023

SUV induces MAP kinase phosphorylation in JB6 P+ mouse epidermal skin cells in a time- or dose-dependent manner. (A) JB6 P+ cells were cultured, treated with SUV (60 kJ/m2) and harvested at the times indicated (0, 15, 30, 60, or 120 min). (B) JB6 P+ cells were cultured, treated with different doses of SUV (0, 5, 15, 30, 60 or 90 kJ/m2) and harvested at 15 min. Protein abundance was analyzed by Western blot. ï�¢-Actin was used to verify equal protein loading. Each assay was performed 3 times and similar results were obtained. Representative Western blots are shown.
Supplementary Figure 3 from Increased Plasma Levels of the APC-Interacting Protein MAPRE1, LRG1, and IGFBP2 Preceding a Diagnosis of Colorectal Cancer in Women
Authors: Ladd Jon J. , Busald Tina , Johnson Melissa M. , Zhang Qing , Pitteri Sharon J. , Wang Hong , Brenner Dean E. , Lampe Paul D. , Kucherlapati Raju , Feng Ziding , Prentice Ross L. , Hanash Samir M.
Published: April 2023

PDF fiel - 144K, Peptide coverage for each of the 6 individual proteins in two colorectal cancer cell lines with different driver mutations.
Supplementary Figures 1-3 from Cryptotanshinone Inhibits Cancer Cell Proliferation by Suppressing Mammalian Target of Rapamycin–Mediated Cyclin D1 Expression and Rb Phosphorylation
Authors: Chen Wenxing , Luo Yan , Liu Lei , Zhou Hongyu , Xu Baoshan , Han Xiuzhen , Shen Tao , Liu Zhijun , Lu Yin , Huang Shile
Published: April 2023

Supplementary Figures 1-3 from Cryptotanshinone Inhibits Cancer Cell Proliferation by Suppressing Mammalian Target of Rapamycin–Mediated Cyclin D1 Expression and Rb Phosphorylation
Supplementary Figure 5 from Slow Overmethylation of Housekeeping Genes in the Body Mucosa Is Associated with the Risk for Gastric Cancer
Authors: Oh Jung-Hwan , Rhyu Mun-Gan , Jung Sung-Hoon , Choi Sang-Wook , Kim Suk-Il , Hong Seung-Jin
Published: April 2023

PDF file - 983KB, Scattergrams for relationships between the APC-methylation level and the age in the H. pylori-negative controls (n = 112), the H. pylori-positive controls (n = 114), and the gastric cancer cases (n = 102). Correlation coefficients (RS) and P values were determined by Spearman's correlation analysis. Horizontal bars and corresponding numbers denote the mean age of H. pylori-negative and -positive controls and cancer patients, which is grouped by the APC-methylation level.
Supplementary Figure Legends from Prostatic and Dietary Omega-3 Fatty Acids and Prostate Cancer Progression during Active Surveillance
Authors: Moreel Xavier , Allaire Janie , Léger Caroline , Caron André , Labonté Marie-Ève , Lamarche Benoît , Julien Pierre , Desmeules Patrice , Têtu Bernard , Fradet Vincent
Published: April 2023

PDF file - 4K
Supplementary Table 2 from Opportunities for the Primary Prevention of Colorectal Cancer in the United States
Authors: Joshu Corinne E. , Parmigiani Giovanni , Colditz Graham A. , Platz Elizabeth A.
Published: April 2023

PDF file - 42K
Supplementary Table 2 from Genetic Variants Associated with the Risk of Chronic Obstructive Pulmonary Disease with and without Lung Cancer
Authors: de Andrade Mariza , Li Yan , Marks Randolph S. , Deschamps Claude , Scanlon Paul D. , Olswold Curtis L. , Jiang Ruoxiang , Swensen Stephen J. , Sun Zhifu , Cunningham Julie M. , Wampfler Jason A. , Limper Andrew H. , Midthun David E. , Yang Ping
Published: April 2023

PDF file - 46K