bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptive Synchronization and Pacing Control for Visual Interactive Simulation
Authors: Meng Zhuoxiao , Gao Mingyue , Grossi Margherita , Siguenza-Torres Anibal , Bortoli Stefano , Sommer Christoph , Knoll Alois
Published: June 2024

Parallel and distributed computing enable the execution of large and complex simulations. Yet, the usual separation of (headless) simulation execution and (subsequent, offline) output analysis often renders the simulation endeavor long and inefficient. Recently, Visual Interactive Simulation (VIS) tools and methods that address this end-to-end efficiency are gaining relevance, offering
in-situ
visualization, real-time debugging, and computational steering. Here, the typically distributed computing nature of the simulation execution poses synchronization challenges between the headless simulation engine and the user-facing frontend required for Visual Interactive Simulation. To the best of our knowledge, state-of-the-art synchronization approaches fall short due to their rigidity and inability to adapt to real-time user-centric changes. This paper introduces a novel adaptive algorithm to dynamically adjust the simulation’s pacing through a buffer-based framework, informed by predictive workload analysis. Our extensive experimental evaluation across diverse synthetic scenarios illustrates our method’s effectiveness in enhancing runtime efficiency and synchronicity, significantly reducing end-to-end time while minimizing user interaction delays, thereby addressing key limitations of existing synchronization strategies.
New Skin‐Relevant Cell Coculture Model With Stratum Corneum–Like Layer
Authors: Quijas Geovani , Lewińska Agnieszka , Łukaszewicz Marcin , Bojanowski Krzysztof
Published: June 2024

Two‐dimensional (2D) cell culture is an important tool in the discovery of skin‐active agents. Fibroblasts and keratinocytes, more rarely fibroblast–keratinocyte cocultures, are usually used for that purpose, where test compounds are added by mixing with the overlaying growth medium. However, such an approach is suboptimal because it lacks the stratum corneum component. The stratum corneum acts as a selective gatekeeper and opposes the intradermal permeation of many compounds that are bioactive when placed in direct contact with cells. One solution is to use reconstituted epidermis, but this approach is costly and time consuming. Here, a model is proposed, where the simplicity and convenience of the 2D cell culture is combined with the advantage of a hydrophobic barrier reminiscent of the skin horny layer. This model was tested with skin‐relevant solvents, as well as with “naked” hydrophilic and encapsulated compounds. Cell viability and collagen stimulation were used as readouts. The results showed that the incorporation of a stratum corneum–substitute barrier on top of a 2D cell culture reduced the cytotoxicity of a common cosmetic solvent, dimethyl isosorbide (DMI), in cell culture and modified the bioactivity of the added actives (magnesium ascorbyl phosphate [MAP] and oligomeric proanthocyanidins [OPCs]/levan biopolymer), which became dependent on their ability to penetrate through a lipidic layer. Taken together, these results indicate a better physiological relevance of this cell culture model in workflows aimed at the discovery and analysis of skin‐active compounds than conventional 2D systems.
Successful Use of Dupilumab in the Treatment of Acquired Perforating Dermatosis Associated with Atopic Dermatitis
Authors: Gori Niccolò , De Luca Eleonora , Chiricozzi Andrea , Sfregola Stefania , Di Stefani Alessandro , Peris Ketty
Published: June 2024

Acquired reactive perforating collagenosis is a rare cutaneous disorder characterised by the extrusion of abnormal connective tissue trough epidermidis and/or follicular units. Reactive perforating collagenosis is often associated with systemic diseases in which pruritus is a common symptom (e.g., diabetes and chronic kidney disease). Less commonly, it has been associated with chronic inflammatory dermatoses, including atopic dermatitis, as in this case. In this report, we describe the exceptional case of a 35‐year‐old man affected by acquired reactive perforating collagenosis associated with atopic dermatitis who was resistant to conventional topical and systemic treatment and experienced complete resolution of clinical signs and symptoms after 12 weeks of treatment with dupilumab. In our patient, the severe pruritus induced by atopic dermatitis likely contributed to the development of acquired perforating collagenosis lesions, which are thought to be a reactive response to chronic scratching and repetitive injury to the skin. Chronic pruritus in atopic dermatitis is known to be driven by type 2 cytokines, including IL‐4 and IL‐13, and dupilumab, a monoclonal antibody inhibiting IL‐4 and IL‐13 signalling, has been shown to be effective in the treatment of moderate to severe atopic dermatitis as well as other type 2‐driven pruritic dermatological conditions. This case supports the potential use of dupilumab for the treatment of reactive perforating dermatosis.
Dietary Erucic Acid Induces Fat Accumulation, Hepatic Oxidative Damage, and Abnormal Lipid Metabolism in Nile Tilapia (Oreochromis niloticus)
Authors: Ma Dingfei , Li Qiangwei , Xie Yuanyuan , Kong Youqin , Ding Zhili , Ye Jinyun , Wu Chenglong , Liu Yan
Published: June 2024

Erucic acid (EA) in rapeseed oil has adverse effects on terrestrial animal and fish health. However, its antinutritional role in fish remains unclear due to the limited information on EA. Therefore, this study was conducted to assess the impact of EA on growth performance, antioxidative capacity, fatty acid profile, and lipid metabolism in tilapia. Six diets containing different amounts of EA (0, 3, 6, 12, 20, and 27 g/kg diet) were fed to tilapia (initial weight: 3.01 ± 0.01 g) for 8 weeks. The results exhibited that dietary EA did not affect growth performance but remarkedly increased the crude lipid contents (in the whole body, liver, and muscle). It also markedly increased the levels of low‐density lipoprotein cholesterol, total cholesterol, nonesterified fatty acids, and triglyceride in the liver and serum in a dose‐dependent manner. The EA groups had lower values of total superoxide dismutase, total antioxidant capacity, catalase, and higher activities of aspartate aminotransferase and alanine aminotransferase, as dietary EA levels increased. Feeding fish with diets containing EA (20 and 27 g/kg diet) significantly increased the malondialdehyde content. Moreover, dietary EA greatly altered the fatty acid profile in the liver and muscle. It especially elevated the percentages of C18 : 2n‐6, C20 : 1n‐9, and C22 : 1n‐9 while decreasing the C18 : 0 and C16 : 0 levels. When the levels of EA in diets were 12, 20, and 27 g/kg, genes correlated with lipophagy, lipolysis, and β‐oxidation were significantly reduced. Meanwhile, genes concerned in triglyceride synthesis were largely increased in the liver and muscle. In summary, high‐dose EA (20 g/kg diet) in the diets significantly induced fat accumulation, hepatic oxidative damage, and abnormal lipid metabolism in tilapia. The current findings expand our understanding on the antinutritional role of EA in lipid homeostasis and fish health.
The Effects of Various Types of Physical Exercise on Health Outcomes in Older Adults with Depression: A Systematic Review and Meta‐Analysis of Controlled Trials
Authors: Alowaydhah Samaher , Weerasekara Ishanka , Walmsley Sarah , Marquez Jodie
Published: June 2024

Background and Purpose. The number of older adults and the occurrence of concomitant health issues continue to grow. One of the most prevalent mental health issues in this population is depression. Physical exercise (PE) is widely acknowledged as a method to alleviate the associated health burdens of aging, including depression; however, there is no collated evidence regarding the effectiveness of specific types of exercise on a range of health outcomes. To address this, we conducted a systematic review to evaluate exercise benefits for this specific subgroup. Methods. An electronic search of five databases was used to retrieve controlled studies investigating health‐related outcomes associated with any type of PE, in adults over 65 years with depression. Where possible, data were analyzed in meta‐analyses or else reported narratively. Results and Discussion. Fifteen studies were included in the review. All 15 studies had data available for meta‐analysis, yet heterogeneity in exercise types and outcome measures limited synthesis. When data for all types of exercise were pooled together, significant improvements were found in depression (SMD = 0.52; CI = 0.07, 0.97; p = 0.02), physical health and function (SMD = 0.44, CI = 0.14, 0.74; p = 0.004), anxiety (SMD = 0.23; CI = 0.04, 0.42; p = 0.02), and self‐efficacy (SMD = 0.97; CI = 0.32, 1.61; p = 0.003). When data were pooled according to exercise type, positive effects were demonstrated for aerobic exercise on depression (SMD = 0.49; CI = −0.16, 0.8; p = 0.003), tai chi/qigong on depression (SMD = 0.89; CI = −0.14, 1.63; p = 0.02), and self‐efficacy (SMD = 6.70; CI = −0.90, 12.50; p = 0.02) and multicomponent exercise demonstrated positive effects on physical function (SMD = 0.49; CI = 0.12, 0.87; p = 0.009) and the physical health component of quality of life (SMD = 0.88; CI = 0.10, 1.65; p = 0.03). No health‐related benefits were revealed from the combined findings of the two studies investigating strengthening exercises. Conclusion. Lack of consistency regarding exercise types, dosage, and outcomes presents challenges in the evidence. In general, exercise is beneficial across a range of health‐related variables. Multicomponent, aerobic, and tai chi forms of exercise appear most likely to reap benefits in depressed older adults; however, the type of benefit is determined by the type of exercise and should be considered when recommending a regime. This trial is registered with CRD42020173465.
Effects of Substituting Fish Meal by Chlorella Meal in Practical Diet on Growth, Feed Utilization, and Flesh Quality of Pacific White Shrimp (Penaeus vannamei)
Authors: Li Menglu , Li Xiaoqin , Yao Wenxiang , Wang Yuanyuan , Li Lufan , Leng Xiangjun
Published: June 2024

This study investigated the effects of substituting fish meal (FM) in practical diet by chlorella meal on the growth, feed utilization, and flesh quality of Pacific white shrimp (Penaeus vannamei). First, a basal diet was prepared with 200 g/kg FM inclusion (FM‐20), and then chlorella meal was used to reduce FM inclusion to 150 g/kg (FM‐15), 100 g/kg (FM‐10), 50 g/kg (FM‐5), and 0 g/kg (FM‐0), corresponding to the replacement levels of 25%, 50%, 75%, and 100% of dietary FM, respectively. Shrimp (1.37 ± 0.10 g) were fed with the five isonitrogenous and isolipidic diets for 56 days. No significant difference was observed in feed conversion ratio (FCR) and weight gain (WG) between FM‐20 and FM‐15 group (P > 0.05), but when chlorella meal substituted 50% of dietary FM, WG, protein and lipid retention, and n‐3/n‐6 PUFAs in flesh were significantly reduced with significant increase in FCR (P < 0.05). Survival, feed intake, meat yield, apparent digestibility coefficient of crude protein, dry matter, and flesh shear force showed no significant difference between FM‐20 and substituted groups (P > 0.05). When dietary FM was totally substituted by chlorella meal, the body yellowness and redness and essential amino acid content in flesh, including Lys and Met, were significantly reduced (P < 0.05). No significant differences were found in flesh total collagen, crude lipid, crude protein, serum biochemical indexes, flesh texture profiles (hardness, springiness, etc.), water holding capacity, antioxidant capacity, fatty acid, free amino acid composition, and muscle fiber density among the five treatments (P > 0.05). To sum up, in a practical diet with 200 g/kg FM inclusion, chlorella meal successfully replaced 25% of dietary FM without adverse impacts on the growth and feed utilization, and the substitution of 75% of dietary FM did not negatively affect the flesh quality of Pacific white shrimp.
Abstract PO-018: Commensal bacteria are required for chronic inflammation and B lymphoma development in myeloid cell-specific TRAF3-deficient mice
Authors: Jung Jaeyong , Zhu Sining , Lalani Almin I , Shakarchi Judith , Wu Guojun Gary , Zong Wei-Xing , Zhao Liping , Xie Ping
Published: June 2024

Myeloid cells are the major players of innate immunity and inflammation. The function of myeloid cells is critically regulated by the adaptor protein TRAF3. We previously reported that aging myeloid cell-specific TRAF3-deficient (M-Traf3-/- ) mice spontaneously develop chronic inflammation and B-cell lymphoma (BCL). Here we sought to identify the internal trigger of chronic inflammation and aberrant B cell activation in these mice. We first detected gut dysbiosis and transmigration of commensal bacteria to the liver in aging M-Traf3-/- mice using 16s rRNA gene sequencing of fecal bacterial DNA and bacterial culture of liver homogenates, respectively. To determine if gut dysbiosis and bacterial transmigration induce chronic inflammation and aberrant B cell activation, we treated mice with broad-spectrum antibiotics. We found that depletion of commensal bacteria with antibiotics effectively prevented chronic inflammation and BCL development in aging M-Traf3-/- mice. We next demonstrated that systemic IgG responses against commensal bacteria were induced in the mice as shown by fecal bacteria FACS analysis. Interestingly, our sequencing data of the IgH gene VDJ region revealed that many malignant B cell clones of M-Traf3-/- mice had undergone class switch recombination and contained somatic hypermutations, indicating their origination from germinal center (GC) or post-GC B cells. We also noticed that the CDR3 sequences of malignant B cell clones derived from M-Traf3-/- mice exhibit high homology to prevalent bacteria-reactive Ig clonotypes. Furthermore, aging M-Traf3-/- mice with BCL contained high titers of antibodies against commensal bacteria, but not autoantigens, in the serum. Taken together, our findings suggest that commensal bacteria dysbiosis and transmigration can promote chronic inflammation and BCL development in individuals with compromised innate immunity. Accordingly, inhibition of commensal bacteria may serve as an effective therapeutic strategy for the prevention and treatment of chronic inflammation and B-cell lymphomas in these patients.

Citation Format: Jaeyong Jung, Sining Zhu, Almin I Lalani, Judith Shakarchi, Guojun Gary Wu, Wei-Xing Zong, Liping Zhao, Ping Xie. Commensal bacteria are required for chronic inflammation and B lymphoma development in myeloid cell-specific TRAF3-deficient mice [abstract]. In: Proceedings of the Fourth AACR International Meeting on Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application; 2024 Jun 19-22; Philadelphia, PA. Philadelphia (PA): AACR; Blood Cancer Discov 2024;5(3_Suppl):Abstract nr PO-018.
Clustering Approaches for Gait Analysis within Neurological Disorders: A Narrative Review
Authors: Hummel Jonas , Schwenk Michael , Seebacher Daniel , Barzyk Philipp , Liepert Joachim , Stein Manuel
Published: June 2024

Background: The prevalence of neurological disorders is increasing, underscoring the importance of objective gait analysis to help clinicians identify specific deficits. Nevertheless, existing technological solutions for gait analysis often suffer from impracticality in daily clinical use, including excessive cost, time constraints, and limited processing capabilities. Summary: This review aims to evaluate existing techniques for clustering patients with the same neurological disorder to assist clinicians in optimizing treatment options. A narrative review of thirteen relevant studies was conducted, characterizing their methods, and evaluating them against seven criteria. Additionally, the results are summarized in two comprehensive tables. Recent approaches show promise; however, our results indicate that, overall, only three approaches display medium or high process maturity, and only two show high clinical applicability. Key Messages: Our findings highlight the necessity for advancements, specifically regarding the use of markerless optical tracking systems, the optimization of experimental plans, and the external validation of results. This narrative review provides a comprehensive overview of existing clustering techniques, bridging the gap between instrumented gait analysis and its real-world clinical utility. We encourage researchers to use our findings and those from other medical fields to enhance clustering techniques for patients with neurological disorders, facilitating the identification of disparities within groups and their extent, ultimately improving patient outcomes.
Regulation of the Lewis Blood Group Antigen Expression: A Literature Review Supplemented with Computational Analysis
Authors: Wipplinger Martin , Mink Sylvia , Bublitz Maike , Gassner Christoph
Published: June 2024

Background: The Lewis (Le) blood group system, unlike most other blood groups, is not defined by antigens produced internally to the erythrocytes and their precursors but rather by glycan antigens adsorbed on to the erythrocyte membrane from the plasma. These oligosaccharides are synthesized by the two fucosyltransferases FUT2 and FUT3 mainly in epithelial cells of the digestive tract and transferred to the plasma. At their place of synthesis, some Lewis blood group carbohydrate antigen variants also seem to be involved in various gastrointestinal malignancies. However, relatively little is known about the transcriptional regulation of FUT2 and FUT3. Summary: To address this question, we screened existing literature and additionally used in silico prediction tools to identify novel candidate regulators for FUT2 and FUT3 and combine these findings with already known data on their regulation. With this approach, we were able to describe a variety of transcription factors, RNA binding proteins and microRNAs, which increase FUT2 and FUT3 transcription and translation upon interaction. Key Messages: Understanding the regulation of FUT2 and FUT3 is crucial to fully understand the blood group system Lewis (ISBT 007 LE) phenotypes, to shed light on the role of the different Lewis antigens in various pathologies, and to identify potential new diagnostic targets for these diseases.
Analysis of the effect of superselective ophthalmic artery thrombolysis for central retinal artery occlusion
Authors: Kang Ningyu , Xue Yan , Wang Fei , Guan Qingliang , Li Min
Published: June 2024

Introduction To investigate the clinical efficacy of superselective ophthalmic artery thrombolysis for central retinal artery occlusion (CRAO).
Methods Retrospective study of CRAO patients who attended the Department of Ophthalmology of Affiliated Hospital of Weifang Medical University from January 2022 to July 2023, 138 CRAO patients with onset time of 1-3 days were selected for the study. Among them, 86 patients refused thrombolytic treatment and chose to adopt traditional treatment, which was categorized as the control group; 52 patients adopted superselective ophthalmic artery thrombolytic treatment, which was categorized as the observation group. The visual acuity of the patients treated with traditional modality on the 4th day after the onset of the disease and the visual acuity of the patients treated with superselective ophthalmic artery thrombolysis on the 1st postoperative day were recorded, and the visual acuity improvement after different modalities of treatment was compared between the two groups.
Results In the control group, 77 (89.5%) of the treated patients had no improvement in visual acuity, 9 (10.5%) had improvement, 0 (0.0%) had significant improvement, and the total improvement was 9 (10.5%); in the observation group, 18 (34.6%) of the treated patients had no improvement in visual acuity, 21 (40.4%) had improvement, 13 (25.0%) had significant improvement, and the total improvement was 34 (65.4%). The total improvement rate of treatment in the observation group was 65.4%, which was significantly higher than the 10.5% in the control group, and the difference was statistically significant (P<0.05).
Conclusion Superselective ophthalmic artery thrombolysis for patients with CRAO is clinically effective, promotes improvement in patient vision, and has a high safety profile.
Identification and Characterization of Pectate Lyase as a Novel Allergen in Artemisia sieversiana Pollen
Authors: Yang De-Zheng , Tang Jian , Cheng Ya-Li , Yang Yong-shi , Wei Ji-Fu , Sun Jin-Lyu , Xu Zhi-Qiang
Published: June 2024

Introduction: Artemisia species are widely spread in north hemisphere. Artemisia sieversiana pollen is one of the common pollen allergens in the north of China. At present, seven allergens were identified and had been listed officially from A. sieversiana pollen, but the remaining allergens are still insufficiently studied, which need to be found. Methods: Pectate lyase was purified from the extracts of A. sieversiana pollen by anion exchange, size exclusion, and HPLC-hydrophobic interaction chromatography. The gene of A. sieversiana pectate lyase (Art si pectate lyase) was cloned and expressed in Escherichia coli. The enzyme activity and circular dichroism (CD) spectrum of natural and recombinant proteins were analyzed. The allergenicity of Art si pectate lyase was characterized by enzyme-linked immunosorbent assay (ELISA), Western blot, inhibition ELISA, and basophil activation test. The allergen’s physicochemical properties, three-dimensional structure, sequence profiles with homologous allergens and phylogenetic tree were analyzed by in silico methods. Results: Natural Art si pectate lyase (nArt si pectate lyase) was purified from A. sieversiana pollen extracts by three chromatographic strategies. The cDNA sequence of Art si pectate lyase had a 1191-bp open reading frame encoding 396 amino acids. Both natural and recombinant pectate lyase (rArt si pectate lyase) exhibited similar CD spectrum, and nArt si pectate lyase had higher enzymatic activity. Moreover, the specific immunoglobulin E (IgE) binding rate against nArt si pectate lyase and rArt si pectate lyase was determined as 40% (6/15) in patients’ serum with Artemisia species pollen allergy by ELISA. The nArt si pectate lyase and rArt si pectate lyase could inhibit 76.11% and 47.26% of IgE binding activities to the pollen extracts, respectively. Art si pectate lyase was also confirmed to activate patients’ basophils. Its structure contains a predominant motif of classic parallel helical core, consisting of three parallel β-sheets, and two highly conserved features (vWiDH, RxPxxR) which may contribute to pectate lyase activity. Moreover, Art si pectate lyase shared the highest sequence identity of 73.0% with Art v 6 among currently recognized pectate lyase allergen, both were clustered into the same branch in the phylogenetic tree. Conclusion: In this study, pectate lyase was identified and comprehensively characterized as a novel allergen in A. sieversiana pollen. The findings enriched the allergen information for this pollen and promoted the development of component-resolved diagnosis and molecular therapy of A. sieversiana pollen allergy.
Risk of Bleeding in Hepatocellular Carcinoma Patients Treated with Atezolizumab/Bevacizumab: A Systematic Review and Meta-Analysis
Authors: Song Young-Gi , Yeom Kyeong-Min , Jung Eun Ae , Kim Sang Gyune , Kim Young Seok , Yoo Jeong-Ju
Published: June 2024

Introduction: The combination of atezolizumab/bevacizumab has emerged as an effective first-line treatment for advanced hepatocellular carcinoma (HCC). However, this therapy is potentially associated with bleeding complications, warranting a comprehensive analysis of their incidence and severity. This meta-analysis aims to synthesize available evidence from clinical trials and observational studies to quantify the prevalence of bleeding following atezolizumab/bevacizumab administration. Methods: This meta-analysis focused on HCC treatment using atezolizumab/bevacizumab, particularly examining bleeding complications. It determined the prevalence of bleeding post-administration and compared the risk ratio with tyrosine kinase inhibitors (sorafenib or lenvatinib). Risk factors for bleeding complications were also evaluated. Results: From 28 studies involving 3,895 patients, the pooled prevalence of bleeding side effects was 8.42% (95% CI: 5.72–11.54). Grade III or IV bleeding occurred in 4.42% (95% CI: 2.64–6.10) of patients, with grade V bleeding observed in 2.06% (95% CI: 0.56–4.22). Gastrointestinal bleeding, predominantly variceal, was the most common, with a prevalence of 5.48% (95% CI: 3.98–7.17). Subgroup analysis indicated variability in bleeding rates based on study design and geographical location. Atezolizumab/bevacizumab treatment exhibited a 2.11 times higher prevalence of bleeding compared to tyrosine kinase inhibitors (95% CI: 1.21–3.66). Meta-regression identified high body mass index (BMI) and higher proportion of albumin-bilirubin (ALBI) grade 3 as significant risk factors for bleeding complications. Conclusion: Atezolizumab/bevacizumab therapy for advanced HCC carries a heightened risk of gastrointestinal bleeding, exceeding that of tyrosine kinase inhibitors. High BMI and higher ALBI grade are key predictors of bleeding complications, emphasizing the need for cautious patient selection and monitoring.
Post-Excision Soft X-Ray Radiotherapy for Keloids: Experience in a Tertiary Referral Center
Authors: Ramelyte Egle , Welti Michèle , Gardin Fabian , Maul Julia-Tatjana , Dummer Reinhard , Imhof Laurence
Published: June 2024

Introduction: Keloid is an abnormal proliferation of scar tissue that grows beyond the original margins of the injury. Even after complete resection, recurrences are common and pose a poorly understood challenge in dermatology. There is lack of large prospective clinical trials; thus, treatment recommendations are based on retrospective analyses and small cohort studies. Superficial radiotherapy is recommended in recurrent keloids; however, the successful treatment rates vary greatly. The aim of this study was to evaluate the keloid recurrence rate after post-excision soft X-ray radiotherapy and the associated factors. Methods: We reviewed retrospective data of all patients, treated with adjuvant post-excision soft X-ray radiotherapy with 12 Gy in 6 sessions at the tertiary referral center, Department of Dermatology, University Hospital Zurich, Switzerland, between 2005 and 2018. We analyzed individual keloids as separate cases. Successful treatment was defined as no sign of recurrence within 2 years. Results: Of the 200 identified patients, 90 met the inclusion criteria and were included in the final analysis. In 90 patients, 104 cases of treated keloids were analyzed. Keloids were mainly located on the trunk (49%) and were mostly caused by previous surgery (52.2%). 50% of the keloids did not relapse within 2 years after therapy. A significant factor leading to recurrence was the presence of previous therapy, with prior topical therapies, such as steroid injections or 5-fluorouracil, leading to most relapses. 69.2% of keloid cases who relapsed were pretreated. Soft X-ray radiotherapy was well tolerated, with posttreatment hyperpigmentation noted in 34% of patients, particularly in patients with non-Caucasian origin (61.3%). Conclusion: Treatment of refractory keloids is difficult. Post-excision radiotherapy is an established adjuvant treatment option; nevertheless, recurrence rates are high, especially in pretreated keloids. Prospective studies determining the exact dosage and fraction of post-excisional radiotherapy are needed to determine the optimal radiation parameters.
The Application of Cohen’s Stress-Buffering Model for Weight Bias Internalization in Prebariatric Patients
Authors: Kaden Jördis , Hübner Claudia , Mansfeld Thomas , Sander Johannes , Seyfried Florian , Kaiser Stefan , Dietrich Arne , Hilbert Anja
Published: June 2024

Introduction: Weight bias internalization (WBI) is associated with reduced psychological well-being in individuals with obesity. The aim of this study was to investigate the application of Cohen’s stress-buffering model of social support for WBI on well-being in patients presenting for bariatric surgery. Methods: In N = 804 adult prebariatric patients, WBI, social support, depression severity, health-related quality of life (HRQOL), and self-esteem were assessed by self-report questionnaires. Structural Equation Modeling was applied to test for direct associations between social support and well-being and for a buffering effect of social support on the relationship between WBI and well-being. Results: After controlling for age, sex, and body mass index, greater social support was directly associated with reduced depression severity and increased self-esteem, but not with increased HRQOL. Contrary to Cohen’s stress-buffering model, social support showed no moderating effects on the association between WBI and depression severity, HRQOL, and self-esteem. Conclusion: These cross-sectional results may indicate that greater social support is associated with improved well-being, supporting it as a potential coping resource in bariatric surgery. Given the absence of supporting evidence for the buffering effect in the present study, future prospective research may reevaluate the existence of a moderating effect of social support and investigate whether support-focused interventions improve psychological well-being.
TRAUMA KIMIA MATA YANG DISEBABKAN POTASSIUM PERMANGANAT (KMNO4)
Authors: Amajida Saraya , Ayu Niluh Putu , Octaviany Efi , Natan Priscilla Christina
Published: June 2024

Pendahuluan: Trauma kimia mata adalah kegawatdaruratan yang sering pada anak-anak. Trauma mata disebabkan oleh senyawa asam maupun basa. Salah satu penyebab trauma kimia pada mata yang jarang ditemui adalah Potassium Permanganat (KMnO4). Laporan kasus ini bertujuan untuk mendeskripsikan tatalaksana trauma kimia mata yang disebabkan Potassium Permanganat di PMN RS Mata Cicendo Bandung. 
Laporan Kasus: Seorang anak laki-laki berusia 3 tahun datang ke Instalasi Gawat Darurat (IGD) Rumah Sakit Mata Cicendo dengan keluhan nyeri, merah dan bengkak pada mata kiri. Pasien terkena cairan KMNO4 ketika sedang bermain 10 jam sebelum masuk ke rumah sakit. Pemeriksaan visus pada mata kanan 6/6 sedangkan mata kiri sulit untuk diperiksa. Terdapat bengkak pada kelopak mata atas dan bawah, senyawa KMnO4 melekat kuat pada konjungtiva tarsal dan konjungtiva bulbi. Kornea keruh dan tes bayangan positif. 
Diskusi: Pasien didiagnosa dengan Trauma Kimia Ropper Hall derajat II OS. Pasien diirigasi dengan 2 liter cairan salin normal sampai mencapai pH 7. Pasien dilakukan transplantasi membran amnion dan debridemen permukaan mata dalam anestesi. Tatalaksana fase awal kasus ini adalah irigasi. Terapi definitif memerlukan pembedahan untuk mempercepat proses penyembuhan. Komplikasi yang sering terjadi adalah defisiensi sel limbus kornea, mata kering, simblepharon, glaukoma sekunder, dan katarak. 
Kesimpulan: Penanganan yang cepat dan agresif diperlukan dalam kasus-kasus seperti ini untuk untuk mendapatkan penyembuhan yang lebih baik.
KARAKTERISTIK PASIEN DIABETES MELLITUS YANG MENGIKUTI PROGRAM SKRINING RETINOPATI DIABETIK BERBASIS KOMUNITAS DI KOTA BANDUNG OLEH RUMAH SAKIT MATA CICENDO PADA TAHUN 2022
Authors: Effendy Varrel Geary Effendy , Rini Mayang , Ratnaningsih Nina , Irfani Irawati , Natalya Susanti
Published: June 2024

Pendahuluan: Retinopati diabetik merupakan komplikasi mikrovaskular yang diakibatkan oleh penyakit diabetes mellitus kronis. Retinopati diabetik memerlukan skrining sebagai deteksi dini untuk mengontrol keparahannya. 
Metode: Penelitian ini bertujuan untuk mengetahui karakteristik pasien retinopati diabetik yang terjaring skrining oleh Rumah Sakit Mata Cicendo pada tahun 2022 serta kelompok yang rentan yang mengalami retinopati diabetik. Karakteristik pasien dikategorikan menjadi karakteristik demografi, klinis, dan status oftalmologis. Desain penelitian ini berupa studi deskriptif potong lintang menggunakan data kuesioner skrinining pasien yang dilakukan pada tahun 2022. 
Hasil: Rumah sakit mata cicendo berhasil melakukan skrining terhadap 435 pasien. Data yang terkumpul menunjukkan pasien yang mengikuti skrining mayoritas perempuan (71,49%), berusia 60-79 tahun (64,6%), memiliki riwayat hipertensi (66,44%), dan memiliki durasi diabetes 5-10 tahun (42,99%). Prevalensi DR dan VTDR dari pasien diabetes mellitus yang mengikuti skrining adalah 20,23% dan 3,68%. Mayoritas pasien berjenis kelamin perempuan (21,54%), kelompok umur 40-59  tahun (23,36%), memiliki riwayat hipertensi (20,76%), memiliki riwayat dislipidemia (22,22%) dan durasi diabetes 5-10 tahun (25,13%) mengalami retinopati diabetik. 
Kesimpulan: Retinopati diabetik rentan terjadi pada orang dengan jenis kelamin perempuan, umur 40-59 tahun, riwayat hipertensi, riwayat dislipidemia, dan durasi diabetes 5-10 tahun.
Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL
Authors: Wang Yi , Chen Guo-Chong , Wang Zheng , Luo Kai , Zhang Yanbo , Li Yang , McClain Amanda C. , Jankowska Marta M. , Perreira Krista M. , Mattei Josiemer , Isasi Carmen R. , Llabre Maria M. , Thyagarajan Bharat , Daviglus Martha L. , Van Horn Linda , Goldsztajn Farelo David , Maldonado Luis E. , Levine Steven R. , Yu Bing , Boerwinkle Eric , Knight Rob , Burk Robert D. , Kaplan Robert C. , Qi Qibin , Peters Brandilyn A.
Published: June 2024

BACKGROUND:

Dietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, and blood metabolites among US Hispanic and Latino adults.

METHODS:

In the HCHS/SOL (Hispanic Community Health Study/Study of Latinos), US exposure was defined by years in the United States (50 states and Washington, DC) and US nativity. A dietary acculturation pattern was derived from 14 172 participants with two 24-hour dietary recalls at baseline (2008–2011) using least absolute shrinkage and selection operator regression, with food groups as predictors of US exposure. We evaluated associations of dietary acculturation with incident CVD across ≈7 years of follow-up (n=211/14 172 cases/total) and gut microbiota (n=2349; visit 2, 2014 to 2017). Serum metabolites associated with both dietary acculturation–related gut microbiota (n=694) and incident CVD (n=108/5256 cases/total) were used as proxy measures to assess the association of diet-related gut microbiome with incident CVD.

RESULTS:

We identified an empirical US-oriented dietary acculturation score that increased with US exposure. Higher dietary acculturation score was associated with higher risk of incident CVD (hazard ratio per SD, 1.33 [95% CI, 1.13–1.57]), adjusted for sociodemographic, lifestyle, and clinical factors. Sixty-nine microbial species (17 enriched from diverse species, 52 depleted mainly from fiber-utilizing
Clostridia
and
Prevotella
species) were associated with dietary acculturation, driven by lower intakes of whole grains, beans, and fruits and higher intakes of refined grains. Twenty-five metabolites, involved predominantly in fatty acid and glycerophospholipid metabolism (eg, branched-chain 14:0 dicarboxylic acid** and glycerophosphoethanolamine), were associated with both diet acculturation-related gut microbiota and incident CVD. Proxy association analysis based on these metabolites suggested a positive relationship between diet acculturation-related microbiome and risk of CVD (
r
=0.70,
P
<0.001).

CONCLUSIONS:

Among US Hispanic and Latino adults, greater dietary acculturation was associated with elevated CVD risk, possibly through alterations in gut microbiota and related metabolites. Diet and microbiota-targeted interventions may offer opportunities to mitigate CVD burdens of dietary acculturation.
Description of Macrobiotus kathyae sp. nov. (Parachela: Macrobiotidae) and first records of tardigrades from Indiana (USA)
Authors: MASSA EDOARDO , VECCHI MATTEO
Published: June 2024

The integrative description of the new species Macrobiotus kathyae sp. nov. is reported in this study along with the first tardigrade records for Indiana (United States of America). The new species is characterized by having spines in the distal part of the processes ornamenting the free laid eggs. This modified Macrobiotus-type of ornamentations was previously reported also in Macrobiotus annewintersae Vecchi & Stec, 2021 with which the new species forms a monophyletic clade. In seven out of the nine examined samples, eight tardigrade taxa were found including the new species, the first record outside the type locality of Macrobiotus basiatus Nelson et al., 2020, and the northernmost location for the genus Barbaria.
A new species of Dicnecidia Diakonoff (Lepidoptera: Tortricidae: Olethreutinae: Eucosmini) from Thailand and Laos
Authors: PINKAEW NANTASAK , MUADSUB SOPITA , JAIKLA SORAYA
Published: June 2024

Dicnecidia browni Pinkaew & Muadsub, sp. nov. is described from Thailand and Laos, representing the first records of the genus from these two countries. Illustrations of adults and genitalia are provided.
A new species of Pachysvastra Moure & Michener (Hymenoptera: Apidae) discovered in Argentina
Authors: ALVAREZ LEOPOLDO J. , LUCIA MARIANO
Published: June 2024

A new species, Pachysvastra luquita, is described and figured from northeastern Argentina, which extends the range of the genus. An identification key for the three known species of Pachysvastra and updated occurrence records are given.
Research on the Influence of Humor Response in the Context of Artificial Intelligence Service Failure: Moderating Effect Based on User Humor
Authors: Shi Yunxia , Zhang Bu , Zhang Rumeng
Published: June 2024

With the development of high and new technology, artificial intelligence technology has been widely used in all walks of life. However, limited by the technical development level and the complexity of the service environment, the failure of artificial intelligence robots is inevitable. How to make an effective remedy has become the focus of attention of enterprises and academia. Based on cognitive-affective system theory of personality, benign violation theory and personality trait congruence theory, this paper conducts three situational experiments. This paper explores the relationship between artificial intelligence humor response, perceived sincerity and user forgiveness in the context of artificial intelligence service failure, and discusses the moderating effect of user humor degree. It is found that artificial intelligence humor response has a positive effect on user forgiveness in the context of service failure, and perceived sincerity plays a part of mediating role. In addition, for users with different degrees of humor, the same humorous reply will cause users to perceive different sincerity, and then lead to different users' forgiveness. This study complements the research on consumer psychology and behavior theory and remedy strategies in the context of service failure by artificial intelligence robots. At the same time, it provides a reference for enterprises how to dynamically adjust the artificial intelligence humor response level according to the user portrait, and further provides practical enlightenment for enterprises to implement effective remedy strategies.
Utilizing the Hartree-Fock Method to Analyze Carbon Dioxide Molecule
Authors: Hasan Enass , Abood Saad
Published: June 2024

The determination of the ground state of the carbon dioxide molecule is conducted through matrix Hartree-Fock computations for a polyatomic molecule. Utilization of basis sets is implemented to achieve a precision that approaches the sub-μ Hartree of the CO2 molecule for the energy levels. Utilizing a 28s14p14d14f atom-centered and a 24sl0plld bond-centered Gaussian basis set, the upper limit for the Hartree-Fock ground state energy of CO2 at its practical picture has been calculated, yielding a value of -187.125408 Hartree. Utilizing our knowledge in diatomic molecules, we approximate the precision of this measurement to fall within 5-6 μ Hartree. The current computations offer a methodology to assess the precision of different basis sets frequently utilized in molecular self-consistent field investigations. These basis sets encompass STOJG, 4-31G, 6-31G, 6-31G(3d), 6-31IG, 6-311+G(3d0, D95, and D95V+(3d)), alongside cc-pVDZ, uug-cc-pVDZ, cc-pVTZ, and aug-cc-pVTZ, which have been proposed for the purpose of investigating electron correlation. We have recently performed calculations on the CO1 ground state at the nuclear geomevy employed in the presenl work using the basis sets proposed by Dunning and co-workers and designated cc-pVQZ. aupcc-pVQZ, cc-pVSZ and nupcc-pVSZ. The estimated basis set truncation emrs for these sets are 0.00371, 0.003 19, 0.00047 and 0.00039 Hartree respectively.
Herbage Yield, Nutritional Quality of Desho Grass (Pennisetum glaucifolium) Mixed with Stylo and Silverleaf Desmodium at Assosa, Western Ethiopia
Authors: Tezera Workneh , Mengistu Solomon , Urge Mengistu , Geleti Diriba , Eshetu Mitiku
Published: June 2024

The study was conducted during the main cropping season of 2019/2020 at Assosa in Benishangul-Gumuz regional state. The aim of the study was to evaluate herbage dry matter yield, nutritional quality and biological compatibility of desho grass mixed with Stylo and Desmodium. The treatments included two legume species (Stylosanthes guyanensis and Desmodium unicinatum) and desho grass with four levels of seed proportions (100%, 75%, 50% and 25%) of the recommended seeding rates of the two legume forages. Randomized complete block design with four replications was used. The results revealed that number of tillers per plant (NTPP), plant height (PH) and leaf to stem ratio (LSR), plot cover and vigor score percentage, dry matter yield (DMY) tha-1, and the quality parameters such as, crude protein (CP), neutral detergent fiber (NDF), acid detergent fiber (ADF), acid detergent Lignin (ADL), In-vitro Dry matter Digestibility (IVDMD) and crude protein yield (CPY) tha-1 were significantly (P<0.05) differed among the different seed proportions of desho grass with legume mixtures. The highest total dry matter yield (11.05 t ha-1) was obtained from the sole desho grass planted with Nitrogen fertilizer followed by sole desho grass planted without fertilizer (10.17 t ha-1 ) from the mixed cropping groups mixed crop containing 75% desho grass and 25% Stylo gives a higher total dry mater yield (7.44 tha-1). On the other hand desmodium sown in pure stands had lower DMY compared to legume-grass mixtures (3.37tha-1). In terms of quality, increasing the seed proportions of both legume species in the mixture resulted in higher CP%, CPY (tha-1) and IVDMD% and lower NDF%, ADF% and ADL% contents. Relative yield total of desho grass-legume mixtures at Desho75 Stylo25 (1.43), Desho50 Desmodium 50 (1.39) and Desho25 Stylo75 (1.33) were better compared to the other mixtures and pure stands. Generally, mixing of desho grass with legume species at different seed proportions of 75% desho grass: 25% stylo and 50% desho grass: 50% Stylo produced better dry matter yield, nutritional quality and compatibility in the study area when compared to the mixed cropped plants. However, the experiment should be conducted for more years at different locations to recommend the best desho grass legume mixtures for Assosa area of Benishangul-Gumuz Regional State. It is also suggested to do on animal performance trial of this result based on animal feeding practice and economic feasibility in order to come up with sound recommendations.
A Case of Transmural Lipoma of the Right Atrium
Authors: Song Lin , Li Xuejie
Published: June 2024

Primary cardiac tumors are a relatively rare disease. About 75% of primary cardiac tumors are benign. The most common histological type is myxoma, followed by cardiac fibroma, lipoma, etc. We report a case of a 53-year-old female patient admitted to the hospital due to "repeated palpitations and tightness of breath for 5 years, worsened for 2 days." Preoperative transthoracic echocardiography revealed a hypoechoic mass approximately 3.1 cm x 3.0 cm in size within the right atrium, suggesting an intracardiac mass: nature? Chest computed tomography (CT) indicated a fat-density nodule within the right atrium, with a larger cross-sectional size of about 3.0 cm x 2.5 cm, suggesting a lipoma. The patient underwent excision of the right atrial mass under cardiopulmonary bypass. Intraoperative transesophageal echocardiography (TEE) revealed a mass within the right atrium, closely connected to the atrial wall, with no signs of tricuspid valve obstruction. Exploration during surgery revealed a yellow, smooth-surfaced mass approximately 3.0 cm x 3.0 cm in size, penetrating the right atrial wall, from which the mass and an additional 2mm margin of the right atrial wall were completely excised. A suitable-sized bovine pericardial patch was used to repair the defect in the right atrial wall. Postoperative TEE showed the disappearance of the right atrial mass. The postoperative pathological result indicated a lipoma. Cardiac lipoma is a rare benign primary cardiac tumor. The common sites of occurrence of this tumor are the right atrium, left ventricle, and pericardium. Based on their location, cardiac lipomas can be divided into three types: subepicardial, intramyocardial, and subendocardial lipomas, with subendocardial lipomas being the most common, accounting for over 50% of primary cardiac lipomas. Clinical symptoms largely depend on the size and growth location of the tumor, and it is generally believed that most cardiac lipomas are asymptomatic. Symptomatic lipomas can be treated with curative surgical excision. Transmural lipomas of the right atrium are relatively rare, and such lipomas may affect adjacent structures both inside and outside the atrial wall. Although the lipoma in this case did not significantly affect valve function or blood flow, the patient experienced repeated symptoms of palpitations and tightness of breath. Despite being a benign tumor, the lipoma in this case exhibited transmural growth within the right atrium, showing a certain degree of invasiveness, making surgical excision an effective treatment method.
Diversity of Cyanobacteria in Some Polluted Wetlands of Nkwen in Bamenda (North-West, Cameroon)
Authors: Parfait Ndjouondo , Fosah Muyang , Teke Ache , Fridolin Choula
Published: June 2024

Human activities more and more intensify the pollution of aquatic ecosystems. These pollutants lead to some Cyanobacteria proliferation causing “blooms” or “efflorescence” and disappearance of sensitive species. The aim of the study was to determine the composition and variation of Cyanobacteria community in some polluted wetlands of Nkwen in Bamenda. Sampling of Cyanobacteria took place from October 2022 to September 2023 by using plankton net for phytoplankton and scrubbing for periphyton. Some hydromorphological and physicochemical parameters of water were measured in situ and in the laboratory. Results showed that species richness of microalgae amounted to 11 families divided into 22 genera and 46 species. Oscillatoriaceae constituted the most important family (26.66% with 12 species) of the Cyanobacteria community, in the study sites. Shannon-Weaver’s index was weak and varied between 1.24 (site 6) and 2.65 (site 2). These results showed that wetlands of Nkwen had a Cyanobacteria community more abundant where the water velocity is low, with high nitrates and phosphates contents. Different Cyanobacteria families with strong proliferation in polluted waters (sites 1, 2 and 3) were: Oscillatoriaceae, Gloeotrichiaceae, Rivulariaceae, Nostocaceae, Merismopediaceae, Microcoleaceae, Microcystaceae and Tolypotrichaceae. On the other hand, the families abundantly present in less polluted waters (sites 4, 5 and 6) were: Chroococcaceae, Pseudanabaenaceae and Aphanizomenonaceae. Thus, physicochemical parameters have an influence on the composition and structure of Cyanobacteria community in wetlands of Nkwen in Bamenda. Monitoring, based on biological indices of Cyanobacteria, could be developed to prevent the risks of perturbation of these wetlands.