bluuebunny/crossref_metadata_2025 huggingface dataset:
Artículos, demostrativos y correlaciones en Mazahua (Otomangue)
Authors: Mora-Bustos Armando
Published: April 2022

En este trabajo se describe la naturaleza semántica, sintáctica y las correlaciones de los artículos y demostrativos en mazahua de San Pedro Potla. La relevancia de este artículo radica en que poco o casi nada se sabe sobre la correlación de artículos y demostrativos en el subgrupo otopame; se parte de la idea de que el mazahua antiguo no disponía en estricto sentido de artículos, en la actualidad esta lengua dispone de dos juegos de artículos que denotan definitud y recognoscibilidad. Por su parte, los demostrativos están expresados en morfemas libres y ligados; su clasificación responde a dos grados de proximidad. Tipológicamente, se justifica la idea de que los artículos se originan a partir de demostrativos; con respecto a las concurrencias de artículo-demostrativo y demostrativos-demostrativos, se propone que el artículo y uno de los demostrativos codifica un sentido particular: la referencia del artículo es reconocible mientras que el demostrativo exhibe una referencia anafórica.
Las emociones en el texto literario. Un análisis digital de la narrativa cervantina
Authors: Rodrigo-Ruiz Débora
Published: April 2022

Varios autores han reconocido la importancia que las emociones juegan en el texto literario, para captar la atención del lector sin que la crítica literaria haya llegado a incorporar estas en su estudio. En el presente trabajo, se realiza el primer análisis digital de sentimiento sobre la narrativa cervantina del que se tiene constancia, con el fin de identificar el uso que su autor realiza de las emociones. Los resultados muestran cómo Cervantes emplea un importante número de léxico emocional que varía en frecuencia y cantidad en el transcurso de su obra. Asimismo, se muestra cómo el cambio constante en la polaridad del texto contribuye a crear cierta tensión emocional que el autor sabe utilizar de forma magistral. Dicho contraste emocional puede observarse no solo a lo largo de cada una de las obras literarias analizadas, sino también a lo largo de la trayectoria literaria de Cervantes. Se trata este de un análisis novedoso, que realiza un acercamiento a un campo de estudio prometedor que presenta resultados de valor y relevancia para el avance en el conocimiento del uso de las emociones en el texto literario.
Etiquetado de acciones y modelos de contexto para la práctica actoral
Authors: Mena Young Bernardo
Published: April 2022

El presente artículo revisa el etiquetado de acciones en el Análisis de la Acción Dramática (AAD) para la práctica actoral, como se ha utilizado en la Escuela de Artes Dramáticas de la Universidad de Costa Rica. Propone que el etiquetado de acciones debería ser abordado desde un análisis pragmático y justifica su vigencia a partir de una reflexión en torno a sus aspectos cognitivos y sociocognitivos.
First records of Gulcamptus huronensis Reid, 1996 (Copepoda, Harpacticoida, Canthocamptidae) from Lake Superior, with morphological notes on the male
Authors: Connolly Joseph K. , Watkins James M. , Rudstam Lars G. , Reid Janet R.
Published: April 2022

Gulcamptus huronensis Reid, 1996 is a seldom-reported harpacticoid copepod known only from two female specimens, one collected from Lake Huron, Michigan, USA, the other from Nunatak Creek, Alaska, USA. Herein, we report a new distributional record for G. huronensis from the meiobenthos of Lake Superior, Michigan and Wisconsin, USA. A total of 12 specimens were collected from four localities across Lake Superior in August, 2018. Additionally, we provide information on the habitats where specimens of G. huronensis were recovered and morphological notes on the previously undescribed male of the species.
Mulheres mil no IFRN - campus Caicó: tecendo saberes e práticas emancipatórias
Authors: Meireles Mirelly
Published: April 2022

Mulheres Mil no IFRN-campus Caicó: Tecendo Saberes e Práticas Emancipatórias consiste em uma coletânea que objetiva retratar práticas e experiências do curso FIC em Costureiro, vinculado ao Programa Mulheres Mil do Instituto Federal do Rio Grande do Norte (IFRN)- campus Caicó. Os artigos foram escritos por docentes, técnicos administrativos, bolsistas, alunos e estagiários que fazem parte do programa. As publicações aqui reunidas mostram pesquisas inerentes ao perfil socioeconômico das mulheres atendidas pelo programa, bem como as consequências positivas do curso para as egressas. Ademais, é exposto um estudo que mostra a boa gestão do projeto no campus Caicó, que culmina em bons resultados. Portanto, a grande maioria dos artigos presentes neste livro trata de relatos de experiências das disciplinas que compõem o curso, como a Aula Inaugural; o Mapa da Vida; Língua Portuguesa; Matemática; Gênero, Cidadania e Direitos da Mulher; e Corte e Costura. Assim, esta obra busca mostrar a relevância do Programa Mulheres Mil na vida das mulheres em situação de vulnerabilidade social, além de buscar um fortalecimento ainda maior desse projeto.
Múltiplos olhares sobre a economia solidária na América Latina
Authors: Rego Diogo , Amorim Rizoneide , Carrascal Ivette
Published: April 2022

Nesse livro, apresentaremos algumas reflexões sobre a Economia Solidária, frutos de pesquisas acadêmicas, a maioria com experiências e reflexões da realidade brasileira, mas também com olhares voltados para outros países da América Latina. Teremos a oportunidade de conhecer dois estudos que retratam o universo dos mercados da/na Economia Solidária: um que aborda a realidade brasileira e outro que traz a experiência da confederação Agrosolidaria da Colômbia. Em seguida, é debatida a era do hiperconsumo com um enfoque para a importância de perceber o consumo responsável e solidário como uma necessidade urgente. Outro estudo traz a problematização sobre os desafios e perspectivas da sustentabilidade para os empreendimentos brasileiros. Teremos ainda debates que visibilizam experiências territoriais brasileiras, como os casos Santa Maria – Rio Grande do Sul/Brasil e Fortaleza – Ceara/Brasil. Os dois últimos estudos abordam a organização do movimento no Equador e no Brasil e uma reflexão sobre o processo de regulação da Economia Solidária, respectivamente.
Ensaios dilatométricos em um depósito de argila mole no bairro do Ibura (Recife - PE)
Authors: Pereira Alexandre , Coutinho Roberto
Published: April 2022

A presente obra trata da republicação da dissertação resultante do curso de mestrado em Engenharia Civil desenvolvido no Centro de Tecnologia e Geociências da Universidade Federal de Pernambuco no período de 1995 a 1997, completando, portanto, 25 anos. A dissertação, intitulada “Ensaios Dilatométricos em Depósito de Argila Mole no Ibura, Recife, PE”, consistiu em trabalho reconhecido como destaque na pesquisa na área de conhecimento da Geotecnia, recebendo o Prêmio “Icarahy da Silveira”, outorgado pela Associação Brasileira de Mecânica dos Solos e Engenharia Geotécnica (ABMS) na data de 08 de novembro de 1998, durante o evento “Congresso Brasileiro de Mecânica dos Solos – XI COBRAMSEG”, realizado em Brasília/DF, concedido na qualidade de melhor dissertação de mestrado em Geotecnia no biênio 1996 – 1998.O nível de excelência do trabalho desenvolvido no mestrado em Geotecnia foi também reconhecido pela UFPE mediante a menção de Honra ao Mérito outorgada pelo Magnífico Senhor Reitor da Universidade Federal de Pernambuco.
The Poetry of Prose: Readings in Russian Literature
Authors: Børtnes Jostein
Published: April 2022

In prose, and especially in narrative prose, the poetic system of repetitive parallel elements is less conspicuous than in verse composition. And yet the poetry of narrative prose is likewise brought about by elaborate systems of parallels and equivalences that prompt the reader to transform the true-to-life representation of events and characters into higher, symbolic levels of meaning. The readings in this book explore the functions of parallelistic patterning in narrative Russian literature: from the figural interpretation of early East Slavic hagiography — the juxtaposition of saints’ lives with the gospel narratives about the life of Christ — to the deployment of related forms of parabolic projection in the works the great nineteenth-century Russian novelists. It is the uncovering of such patterns that provides access to the symbolic dimension of the Russian novel.
Desafios na avaliação da atenção básica a partir de um programa de melhoria da qualidade
Authors: Ferreira Lucilene Renó , Neves Vanessa Ribeiro , Rosa Anderson da Silva
Published: April 2022

RESUMO Objetivo analisar os processos de trabalho decorrentes do Programa de Melhoria do Acesso e da Qualidade da Atenção Básica, segundo profissionais da Atenção Básica atuantes na assistência e em diferentes níveis de gestão. Método estudo de caso único e descritivo, com 18 profissionais da assistência e gestão no município de São Paulo, no ano de 2017; uso da história oral temática como técnica de coleta de dados, categorização e análise a partir da tríade avaliativa de Donabedian. Resultados observou-se fragmentação entre assistência e gestão ao se implementar o Programa, influência de características organizacionais e institucionais, percepção de implantação normativa, necessidade de revisar a remuneração de desempenho. O Programa foi norteador para o uso no Planejamento e mobilizou a reflexão sobre a aplicabilidade dos resultados da avaliação e de indicadores. Conclusão e implicações para a prática o estudo revelou predomínio de percepções sobre estrutura e processo, e maior necessidade de reflexão sobre o impacto de programas de qualidade no cuidado e resultados de saúde do usuário.
A Python implementation for the simplified dam-break flood modeling
Authors: Rolo Roberto Mentzingen , Marodin Francisco Antonello , Carrard Giulia Pacheco , Cardone Luciano Brasileiro , Silveira Carlos José Sobrinho da
Published: April 2022

ABSTRACT Since 2010, the Brazilian government has required that dams that fall within the national dam policy must present a safety plan, which, among other topics, must address the definition of the hypotheses and possible disaster scenarios. To achieve it, the flood zone due to an eventual failure must be modeled for the Hazard Potential (Dano Potencial Associado – DPA) classification. The flood zone is the result of complex hydraulic phenomena that are difficult to characterize. Given the demand for DPA analysis and the data unavailability, the National Water Agency (Agência Nacional de Águas - ANA) proposed a simplified methodology for generating the flood zone., This paper proposes a Python implementation for this methodology with a user-friendly Graphical User Interface. Our implementation relies on free and open-source software. The results are similar to those produced by the original implementation and can be generated considerably in less time and with less user interaction.
Circadiane Rhythmik im soziotechnischen Wandel
Authors:   FOM Hochschule für Oekonomie und Management, Essen, Kantermann Thomas , Mork-Antony Friederike Sophie ,   FOM Hochschule für Oekonomie und Management, Essen, Kuhls Kerstin ,   Fraunhofer-Institut für System- und Innovationsforschung (ISI), Karlsruhe
Published: April 2022

Der soziotechnische Wandel hin zur Durchdringung der Arbeitswelt mit immer mehr digitalen Geräten verläuft schleichend. Eine mögliche Folge ist eine Entstrukturierung des Alltags, wodurch die innere Uhr aus dem Takt geraten kann. Erholsamer Schlaf ist untrennbar mit der inneren Uhr verbunden und maßgeblich am Wohlbefinden beteiligt. Bei der Entwicklung von modernen Präventionsstrategien gilt es, die Entrythmisierung des Körpers zu verhindern, um gesundheitliche Folgen zu minimieren.
Mixed-Method-Evaluation betrieblicher Gesundheitsförderung
Authors:   Siemens AG, Environmental Protection, Health Management and Safety (EHS), Frankfurt am Main, Pelster Klaus , Franke Ralf ,   Siemens AG, Environmental Protection, Health Management and Safety (EHS), Frankfurt am Main, Birner Ulrich ,   Siemens AG, Head of Psychosocial Health and Well-being, München, Blaschke Simon ,   Fakultät für Sport- und Gesundheitswissenschaften, Sport- und Gesundheitsdidaktik, Technische Universität München, Friesen David ,   Institut für Bewegungs- und Neurowissenschaft, Abteilung für Bewegungs- und Gesundheitsförderung, Deutsche Sporthochschule Köln
Published: April 2022

Zwei Kernfragen betrieblicher Gesundheits-Präventionsprogramme sind, ob die richtigen Personen die für sie bestmöglich passenden Maßnahmen angeboten bekommen und wie nachhaltig diese Maßnahmen sind. Die Siemens AG hat dazu zusammen mit universitären Partnern einen Gesundheitscheck sowie 4- bis 22-tägige stationäre Gesundheitstrainings einer umfassenden Evaluation mit einem Mix aus qualitativen und quantitativen Verfahren unterzogen. Die Ergebnisse sind ermutigend und liefern wertvolle Daten für die Planung und Weiterentwicklung des betrieblichen Präventionsportfolios.
Assisted Reproductive Technologies: A Grey Zone in the Zika Epidemic in Brazil?
Authors: Prado Helena
Published: April 2022

In this article, I address an issue that emerged during my ethnographic fieldwork in Brazil in 2018, which received little attention during the Zika virus outbreak that took place in the country during 2015–17. My fieldwork revealed that, interestingly, despite the epidemic and its associated risk of birth defects, some couples who were attending a fertility clinic (most of whom came from a middle- or upper-class background, with access to private health care) chose to take the risk of a pregnancy instead of delaying their plans. I argue that this case study of assisted reproductive technology (ART) is a ‘grey zone’ whose investigation aids understanding of how the Zika epidemic was managed in Brazil. By looking at the potentiality of pregnancies and prospective babies for (infertile) couples, we can analyse how fertility clinics influenced the ability of couples to engage in ART during the epidemic and explore which kinds of reproductive services were offered to patients during this time. More broadly, this case study permits the examination of how the specific case of ART sheds light on the issue of risk/reward in wider reproductive decision-making during the epidemic. In many ways, I conclude, one can say that the Zika virus epidemic came to challenge both the timing of reproduction and the choice to become pregnant.
Becoming a Mother During COVID-19: Adjustments in Performing Motherhood
Authors: Jullien Clémence , Jeffery Roger
Published: April 2022

Based on online semi-structured interviews with middle-class women who were pregnant or had recently given birth in Western Europe (France, Spain, the United Kingdom, and Switzerland), this study analyses how motherhood has been experienced and performed during the COVID-19 pandemic. The article reflects on the specific new risk assessments and responsibilities that emerged during the pandemic by showing women’s coping strategies concerning lockdowns and other public health measures. Using a COVID-19 lens also allows a broader analysis of middle-class families’ concerns about performing ‘good motherhood’. By highlighting the discrepancies between women’s expected and actual experiences, the prescriptive aspects of pregnancy, delivery, and the postpartum phase are revealed and analysed, prompting us to consider parenting as a form of doing and proving. By underlining the importance attached to the expectant mother’s wellbeing, the partner’s involvement, the support of relatives, and the future socialisation of the baby, we argue that women face a myriad of imperatives to ensure a meaningful experience of motherhood.
Urgent Priorities, Slow Scholarship
Authors: Editorial Collective MAT
Published: April 2022

Editorial to the April issue of 2022.
Utility of geospatial techniques in estimating dam water levels: insights from the Katrivier Dam
Authors: Sisipho Ngebe  , Kasongo Benjamin Malunda  , Anja du Plessis
Published: April 2022

To achieve informed integrated water resource management and sustainability, an understanding of the quantity of water available for use within a spatial and temporal context is needed. This study was consequently focused on the estimation of water levels with the use of geospatial techniques. The availability of water data is a significant challenge, especially for smaller dams used by farmers. The lack of consistent water data in turn poses a problem by limiting the estimation of the overall water availability in water strategy models. This challenge is attributed to the cost of modeling all available water resources and the lack of complete records of all available water resources, as some small dams are not officially registered. This paper provides a simple protocol that can be implemented to reliably derive water levels for dams that are yet to be registered or accounted for, using the Katrivier Dam as a case study. Three main datasets were used which enabled the calculation of water levels – a 12.5 m digital elevation model, Sentinel-2 optical images, and water data from the Department of Water and Sanitation (DWS), as in-situ data. The resulting water level values were derived using a proposed model that includes two correction factors, k and s. The results obtained showed that the estimated water levels from the model proposed in this paper are analogous with those observed by the DWS. Therefore, the proposed method can serve as an additional cost-effective method in water accounting procedures as it requires less expensive equipment than alternatives such as bathymetric methods.
Konteyner Yatırım Kararları için Analitik Bir Yaklaşım
Authors: YALÇIN Ender
Published: April 2022

Konteyner taşımacılığında, taşıyıcılar taşıma faaliyetlerinde genelde kendi konteynerlerini kullanmaktadır. Bununla birlikte yüksek yatırım miktarı ve yatırım riski dolayısıyla bazen kendi konteynerlerini kullanmak doğru karar olmayabilmektedir. Bu durumda, taşıyıcılar bir süreliğine konteyner kiralayabilir veya müşterilerin kendi konteynerlerini kullanmasını özel navlunlar ve konteyner elleçleme maliyetleri gibi çeşitli şekillerde teşvik edebilir. Böylece hem taşıyıcı ekipman sıkıntısına en ekonomik-sürdürülebilir şekilde çözüm üretir, hem de müşteri daha ekonomik hizmet alımına gidebilir. Özellikle artan rekabet ve konteyner taşımacılığında görülen azalan kâr marjında, bu karar yatırım dengesinin iyi kurulması kaydıyla avantaj sağlayabilir. Bu çalışmada yazar Tip 2-Bulanık TOPSIS’e başvurarak, konteyner yatırımı, konteyner kiralama veya müşterinin kendi konteynerini kullanma durumlarını fayda-maliyet-karlılık ekseninde analiz etmiştir. Araştırma bulguları göstermiştir ki, taşıyıcılar için getirisi nedeniyle en çok başvurulan yaklaşım kendi konteynerlerini kullanmak olmuştur ve çoğu firma tarafından müşteri konteynerini kullanmaya yönelik teşvik edici hamleler bulunmamaktadır. Özellikle boş konteyner temininde sıkıntı yaşanan destinasyonlarda müşteri konteyneri kullanımı ve teşviki, operatörlere maliyet avantajı sağlayabilecektir. Bu sebeple, bazı özel durumlar için müşteri konteyneri kullanımında politika önceliklerinin planlanması önerilmektedir.
Sipariş İşlemenin Lojistik Performansa Etkisinde Tedarik Etkinliğinin Aracılık Rolü
Authors: ÖZGÜNER Zeynep , AYTEKİN Mehmet
Published: April 2022

Lojistik performans, firmalarda değer oluşturmanın yanında kurum etkinliğinin artmasına da katkı sağlayarak müşteri memnuniyetinin artmasında ve entegre olarak firma başarısında kritik bir öneme sahip olmuştur. Sipariş zamanlarının azalması, daha güvenilir ve hızlı bir akış ile teslimatların gerçekleşmesinde optimum sayıda tedarikçi sayısı ile tedarik etkinliğinin sürdürülmesi gibi faaliyetler işletmelere önemli kazanımlar sağlamaktadır. Diğer taraftan etkin olmayan bir lojistiğin, firmaların ticari anlamdaki maliyetlerini yükseltmekte olduğu ve küresel bütünleşme potansiyelini düşürmekte olduğu gözlenmektedir. Üretim işletmelerinin bu noktada tedarik etkinliği ve sipariş işleme noktasında entegre bir yaklaşımı takip ederken, lojistik performansı göz ardı etmeyen bir süreç izlemesi önemsenmektedir. Bu çalışmada işletmelerin sipariş işleme fonksiyonunun lojistik performansa etkisinde tedarik etkinliği fonksiyonunun aracılık rolü YEM ile test edilmiştir. Bu doğrultuda hazırlanan anket ölçeği Gaziantep OSB’lerinde faaliyet göstermekte olan 246 imalat işletmesinde uygulanmıştır. Tespit edilen bulgular neticesinde işletmelerdeki sipariş işlemenin lojistik performans üzerinde hem doğrudan etkisi hem de tedarik etkinliği aracılığı ile dolaylı etkisi olduğu tespit edilmiştir.
Seküler Stagnasyon Bağlamında Gelişmiş Ülkelerdeki Ekonomik Büyümenin Türkiye Ekonomisine Etkisi
Authors: SARIDOĞAN Hasan Önder
Published: April 2022

Seküler stagnasyon teorisi ilk olarak 1939 yılında Alvin Hansen tarafından Büyük Buhran sırasında Amerikan ekonomisinin durumunu ortaya koymak amacı ile geliştirilmiştir. Hansen'in teorisinden yetmiş yıl sonra küresel kriz ve sonrasında meydana gelen gelişmeler nedeniyle teori tekrar gündeme gelmiştir. Küresel krizden sonra gelişmiş ülkelerin büyüme hızı büyük ölçüde düşerek seküler (kalıcı) durgunluğa maruz kalmıştır. 2008 yılında gelişmiş ekonomilerin finansal piyasalarında başlayan ekonomik kriz çeşitli şekillerde gelişmekte olan ülkelere yayılmıştır. Bu çalışmada, gelişmiş ekonomilerdeki büyümenin Türkiye büyüme hızı üzerindeki etkisi, VAR modeli, Etki-Tepki Fonksiyonları ve Varyans Ayrıştırma yöntemi ile ampirik olarak analiz edilmiştir. ABD büyüme hızı, Avrupa büyüme hızı, Japonya büyüme hızı ve Türkiye büyüme hızı değişkenlerinden oluşan model, 1980-2019 dönemi için tahmin edilmiştir. Analiz sonuçlarına göre Avrupa ekonomik büyümesi, Türk ekonomisini ABD büyümesinden daha fazla etkilemektedir. Japonya ekonomik büyümesi etkisinin ise sınırlı olduğu görülmektedir.
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Authors: Keto Subgenix
Published: April 2022

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Some Systems of Transcendental Equations
Authors:   Siberian Federal University, Kytmanov Alexander M.
Published: April 2022

Several examples of transcendental systems of equations are considered. Since the number of roots of such systems, as a rule, is infinite, it is necessary to study power sums of the roots of negative degree. Formulas for finding residue integrals, their relation to power sums of a negative degree of roots and their relation to residue integrals (multidimensional analogs of Waring’s formulas) are obtained. Calculations of multidimensional numerical series are given
Algorithm of the Regularization Method for a Singularly Perturbed Integro-differential Equation with a Rapidly Decreasing Kernel and Rapidly Oscillating Inhomogeneity
Authors:   National Research University ", Bobodzhanov Abdukhafiz A. ,   Moscow Power Engineering Institute"
Published: April 2022

In this paper, we consider a singularly perturbed integro-differential equation with a rapidly oscillating right-hand side, which includes an integral operator with a rapidly varying kernel. The main goal of this work is to generalize the Lomov’s regularization method and to reveal the influence of the rapidly oscillating right-hand side and a rapidly varying kernel on the asymptotics of the solution to the original problem
Aktiviti Antimalarial secara in vitro Kompleks Logam Ligan Makrosiklik Tetraaza terhadap Strain Plasmodium falciparum K1
Authors: Norazmi Nur Aqilah Zahirah , Mukhtar Nur Hafizah , Ali Amatul Hamizah , Abd Karim Nurul Huda , Mohd Yusoff Siti Fairus , Agustar Hani Kartini , Mohd Abd Razak Mohd Ridzuan , Hassan Nurul Izzaty
Published: April 2022

Malaria masih lagi kekal menjadi salah satu penyakit endemik yang boleh membawa maut dan rawatan yang digunakan kini untuk merawat malaria adalah terapi gabungan artemisinin. Namun begitu, akses kepada rawatan ini adalah sangat terhad dan memberi kesan besar kepada negara miskin disebabkan kos terapi yang tinggi. Penilaian aktiviti antimalaria bagi kompleks organologam berasaskan ligan makroksiklik tetraaza masih kurang meluas dijalankan. Ligan makrosiklik tetraaza 5,5,7,12,12,14- heksametil-1,4,8,11- tetraazasiklotetradeka-7,14-dienium bromida, dikomplekskan dengan empat logam peralihan iaitu Cu(II), Pb(II) dan Ni(II) dan Cd(II). Aktiviti antimalarial secara in vitro ke atas strain parasit Plasmodium falciparum yang rintang terhadap klorokuina, K1 ditentukan dan dibandingkan dengan aktiviti antiplasmodial sebatian klorokuina dan artemisinin. Kompleks [Cd(L)(OAc)]Br- merencat pertumbuhan parasit dengan 50% kepekatan perencatan berkesan (EC50) dalam julat aktiviti antiplasmodium yang poten (EC50<1 μM) manakala Cu(L)(OAc)]Br- menunjukkan kesan aktiviti antiplasmodium sederhana (20< EC50<100 μM). Aktiviti kesitotoksikan terhadap sel mamalia Vero yang ditunjukkan oleh kompleks logam Cd(II) berada dalam julat sederhana toksik (10 μM <CC50< 100 μM), manakala, Cu(II), Pb(II) dan Ni(II) berada dalam julat tidak toksik (CC50>100 μM). Nilai indeks pemilihan yang tinggi turut ditunjukkan oleh kompleks Cd(II) iaitu 60.5 seterusnya menjadikan kompleks ini berpotensi untuk dibangunkan sebagai agen antimalaria.
The Senescence Effect of Zoledronate on Three-Dimensional Oral Mucosa Model
Authors: Shaharuddin Nur Bashira , Jones Danial , Chai Wen Lin
Published: April 2022

Zoledronate (ZOL) is an antiresorptive bisphosphonate used to prevent bone loss in skeletal-related disorders, especially in patients with advanced cancer metastatic to bone. However, this medication led to an oral lesion known as medication-related osteonecrosis of the jaw (MRONJ) which also presents clinically as unhealing soft tissue in the jaw. Keratinocytes are thought to be a significant onset factor for MRONJ and recent findings have shown evidence of senescence in keratinocytes. However, little is known about the effect of senescence-associated inflammation that may cause age-associated tissue degeneration, which relates mainly to the expression of extracellular modulators including cytokines known as senescence-associated secretory phenotype (SASP). The aim of this experiment was to investigate the effect of ZOL treatment and senescence-associated secretory phenotype (SASP) if any, on a three-dimensional oral mucosa model (OMM) in which a novel modification was made to reflect the existence of basement membrane (BM) and lamina propria accurately. The ZOL dosage for the model was optimized by exposing the immortalized human oral keratinocyte line (OKF 6/TERT-2) and normal human oral fibroblasts (NHOF) to ZOL at increasing dosages and then histoarchitecture of OMM was examined. Analysis of the model's histology showed significant epithelial thinning upon ZOL treatment and breakage of the BM accompanied by downward proliferation towards the lamina propria. A significant release of SASP molecules (MMP-3 and IL-8) was also detected upon treatment. Therefore, this study suggests that ZOL may impair healing at multiple types of tissues, originally from keratinocytes, by the deleterious effects of the senescence-associated inflammatory response.
Protocatechuic Acid Induces Apoptosis in Human Osteosarcoma Cells by Regulating P13K/AKT/ROS Pathway
Authors: Mei Qiyuan , Chen Xiaohu , Liu Wei
Published: April 2022

Previous investigations have demonstrated that protocatechuic acid (PCA) provides anti-tumour properties in different tumour cell types. It does, however, have an unknown cause on osteosarcoma cells. In this investigation, the underlying mechanism of the effect of PCA on osteosarcoma cells (MNNG or HOS) was investigated and established. The viability of the cell was assessed with the MTT test. Acridine orange/ethidium bromide staining and Western blot analysis were conducted for assessment of cell apoptosis. Western blot analysis was identified for cell cycle progression. In addition to establishing the above findings, the Western blot analysis demonstrated that PCA mediated osteosarcoma cellular apoptosis by triggering the apoptotic pathway of Caspase-9. Additionally, we found that PCA considerably stimulated osteosarcoma cell apoptosis and arrest of cell cycle proliferation by controlling a pathway involving P13K/Akt/ROS signalling. In short, we observed that PCA prevented the advancement of osteosarcoma through the stimulation of apoptosis in osteosarcoma cells. The mechanism underlying this study also showed that PCA generated effective anti-tumour activity on osteosarcoma cells by controlling the signalling pathways of P13K/Akt/ROS.
Matrilineal Marriage Traditions and Hegemonic Masculinity in Marah Rusli’s Sitti Nurbaya
Authors: Bahardur Iswadi , Andayani Andayani , Suwandi Sarwiji , Wardani Nugraheni Eko
Published: April 2022

This article offers an intensive analysis and discussion regarding the practice of hegemonic masculinity in the matrilineal marriage tradition belonging to the Minangkabau ethnic group in the western part of Indonesia's Sumatera archipelago. The rules of Minangkabau matrilineal customs that still place men as policymakers for women are a contributing factor to the practice of hegemonic masculinity. The data source used to examine the problem is an Indonesian novel set in Minangkabau society and culture entitled Sitti Nurbaya by Marah Rusli. Text data obtained from the novel Sitti Nurbaya were analyzed using content analysis techniques. After analyzing the stages of data reduction, data display, and data verification, it was found that two matrilocal marriage traditions in Minangkabau society show the practice of hegemonic masculinity, namely a) kawin bajapuik tradition; and b) the tradition of polygamy. The hegemonic masculinity in both traditions is characterized by the superiority of male power in regulating the conditions of marriage and the emphasis on female obedience as subordinate objects. This study is considered to have greatly contributed to the initial study of masculine literature in the Minangkabau matrilineal society, the study of the revitalization of its gender mainstreaming, as well as efforts to find out the description of the social reality of Minangkabau society in the early 20th century.
“The System Is the System, Isn’t It?”: The Case for a Just Devolution
Authors: O'Farrell Liam , Zwicky Roman
Published: April 2022

How do actors involved in decision-making around urban planning relate to devolution? How do they perceive external forces influencing their cities, and how can the interventions they make be better oriented towards tackling inequalities? We reflect on these questions with data from interviews conducted with urban leaders and housing and development policy stakeholders in the second cities of Birmingham, UK, and Lyon, France. We compare narratives and assess how they relate to the concept of spatial justice in differing contexts of devolution. Drawing from findings in two cities with distinct governance structures, we uncover common issues with neoliberal, growth-oriented mindsets among key actors, despite contrasting rhetoric around social justice. We contend that there is thus a need to define mechanisms for making devolution more attentive to inequalities. This could be achieved through incorporating the concept of spatial justice into devolution strategies. We further argue that, while autonomy to make decisions is an important aspect of devolution, this autonomy needs to be operationalised within an appropriate constellation, including a progressive political-economic culture, sufficient bureaucratic authority and resources, and an active and informed citizenry. As such, devolution is a two-way process of having powers devolved from above and building capacity from below to make use of these powers effectively. We conclude by reflecting critically on the potential of existing strategies in the two contexts to overcome social inequalities and realise the aspirations of “just devolution.”
On Solving the Problem of Estimating the Probability of Fulfilling the Developed Plan
Authors: Voronov M.V.
Published: April 2022

The issues of assessing the probability of the implementation of the developed enterprise activity plan are considered. The use of a constructive simulation method is proposed, which provides the possibility of developing software complexes for automatic development of plans with a full set of estimates of their characteristic indicators, including the probability of the plan implementation, on a single methodological basis.
Multifunctionality of the Prosecutor’s Office of the Russian Federation as a Principle of its Organization and Activities
Authors: Aleva-German E.A. A.
Published: April 2022

The paper is devoted to the principles of organization and activities of the Prosecutor’s Office of the Russian Federation. The author analyzes the views of leading representatives of the legal scientific community on this legal category as the foundation for building legislation on the prosecutor’s office, and notes the high debatability of the issues of the functional structure and purpose of the national prosecutor’s office in the Russian state. Concluding about the insufficiently complete development of the principles of organization and activities of the prosecutor’s office, the author formulates a new principle, which is proposed to be called the principle of multifunctionality. The author studies multifunctionality as a key feature of the domestic prosecutor’s office and as a relatively independent legal phenomenon. The consolidation of the multifunctionality of the prosecutor’s office in the Constitution of the Russian Federation and in the Federal Law “On the Prosecutor’s Office of the Russian Federation” is analyzed. The author concludes that the formulated provision on the multifunctionality of the Russian prosecutor’s office fully complies with the features of the sectoral principle of organization and activities of the prosecutor’s office.
Methodic problems of psychopharmacotherapy and labour rehabilitation of psychic patients
Authors: Karpov A. M.
Published: May 2022

The results of a study of psychopharmacotherapy of psychic patients in the process of their labour rehabilitation are presented. The aims of production and medical staff (at respectively, fulfilment of a plan, routine and supervision) are the social hendicaps to potential ability to work even with the most adequate pharmacotherapy. The choice of the complex of psychotropic agents and labour activity type is to be performed in accordance with clinical and social characteristics of patients.
Rehabilitation of patients with traumatic and compressive neuropathies
Authors: Zhulev N. M. , Zhulev S. N.
Published: May 2022

The famous and unique methods of conservative therapy of various forms of neuropathies are presented, and their results are estimated. The utility of the combined pathogenetically justified treatment is shown. The positive results the complete recovery of functions of the nerve and extrimity are obtained in 82,3% of the patients. The method may be used not only in a hospital but in conditions of the special-purpose neurologic hospital department as well.
Traumatic disease - general pathological concept or nosological category?
Authors: Eryukhin I. A.
Published: May 2022

The concept of "traumatic illness" is related by the author only to severe shockogenic, mainly concomitant trauma. Based on the analysis of 2650 cases of concomitant injury and 978 cases of combat concomitant injuries, it was found that during a severe injury after removing the victim from shock, there are general patterns that are revealed, in particular, when comparing the causes of deaths at different times after injury. The author defines traumatic illness as a scientific problem and as a clinical concept that establishes the main patterns of cause-and-effect relationships between the nature of the injury and the features of traumatic shock, on the one hand, and the features of the clinical course after the victim is removed from shock, on the other. Taking into account the revealed patterns, practical recommendations are given for the treatment of the considered contingent of patients
Treatment of gunshot wounds to the hand
Authors: Nikolenko V. K.
Published: May 2022

Main Military Clinical Hospital named after N. N. Burdenko, MoscowA working classification of gunshot wounds to the hand is proposed, based on the features of damage caused by different types of ammunition, as well as the direction and localization of the impact of shells and their destructive forces. A comparative analysis of the treatment of gunshot wounds to the hand in two statistically equal groups (676 victims) was carried out. In the 1st group, general surgical methods of treatment were used, in the 2nd group, primary reconstructive-restorative treatment was carried out. The favorable functional results obtained in the 2nd group, a significant decrease in the frequency of purulent complications, and a reduction in the duration of treatment confirmed the possibility and high efficiency of primary restorative and reconstructive interventions on the hand. The features of the treatment of wounds of the hand with combined and multiple injuries (284 wounded), as well as against the background of infectious diseases are shown
On the classification of post-traumatic knee instability
Authors: Mironov S. P. , Orletskiy A. K. , Tsykunov M. B.
Published: May 2022

The classification of post-traumatic instability of the knee joint is proposed. The types of instability are distinguished - simple, complex and combined. For complex instability, types are distinguished (anteromedial, anterolateral, posteromedial and posterolateral), which in turn are divided into degrees (according to the severity of displacement of the articular surfaces). Possible variants of displacements of articular surfaces are given. Clinical criteria for determining the form of instability (decompensated, subcompensated and compensated) are given
Preoperative examination and surgical treatment using a distraction apparatus for congenital malformations of the hand in children
Authors: Malakhov O. A. , Belyaeva A. A. , Blinov A. V.
Published: May 2022

Surgical treatment of 66 children with various malformations of the hand was carried out. The importance of serial angiography of the hand and forearm in the preoperative examination of patients is shown. The use of the distraction method using the apparatus developed in the department made it possible to increase the volume of local plastic resources in syndactyly and cicatricial deformities of the hand, and also made it possible to lengthen the underdeveloped bone segments in severe malformations of the hand. The majority of patients received good and satisfactory results
Compensated and decompensated vertical posture of a patient with scoliosis
Authors: Belenkiy V. E. , Popova M. Yu.
Published: May 2022

In 40 patients with thoracic and combined scoliosis of III and IV degrees, the loading of both legs during standing and walking was determined using Kistler dynamometric platforms. The results of the studies and analysis of posture characteristics allowed the authors to distinguish two options for compensating for the imbalance in the body that occurs during the formation of the primary curvature of the spine. A number of provisions are made regarding the pathogenesis of scoliosis, predicting the course of the disease, as well as treatment
Ciberabuso no namoro: Que relação com a sensibilidade moral numa amostra de estudantes universitários?
Authors: Costa Bárbara , Simões Margarida , Carvalho Relva Inês , Azevedo Maria da Conceição
Published: April 2022

A presente investigação procurou explorar a relação entre ciberabuso no namoro e sensibilidade moral numa amostra de estudantes universitários. A amostra foi constituída por 239 estudantes universitários com idades compreendidas entre os 17 e os 49 anos (M = 21.50; DP = 4.70). Foram utilizados como instrumentos a Escala de Sensibilidade Moral (ESE), o Questionário sobre Ciberabuso no Namoro (CibAN) e um questionário sociodemográfico. Os principais resultados sugerem que existem diferenças em função do sexo nas dimensões Ler e Expressar Emoções, Tomar Perspetiva dos Outros, Cuidado ao conectar-se com outros e Gerar Interpretações e Opções, sendo que o sexo feminino, de um modo geral, apresentou níveis superiores comparativamente ao sexo masculino. Relativamente à variável ciberabuso no namoro, foram encontradas diferenças estatisticamente significativas em função do sexo nas dimensões vitimação – agressão direta e perpetração – agressão direta, sendo que o sexo masculino apresentou maior pontuação face ao sexo feminino em ambas. Verificaram-se ainda correlações negativas significativas entre dimensões do ciberabuso e dimensões da sensibilidade moral. Face aos resultados evidenciados, considera-se de extrema relevância a implementação de programas de intervenção direcionados para o desenvolvimento de competências ligadas à sensibilidade moral pois estas parecem permitir o desenvolvimento de comportamentos pró-sociais, contribuindo assim para a diminuição de comportamentos desviantes.
Analysis of six-year monitoring of common pathogens causing periprosthetic joint infection of major joints and the tendency to resistance
Authors:   National Medical Research Center of Traumatology and Orthopedics n.a. N.N. Priorov, Moscow, Russian Federation, Tsiskarashvili A.V. , Melikova R.E. ,   National Medical Research Center of Traumatology and Orthopedics n.a. N.N. Priorov, Moscow, Russian Federation, Novozhilova E.A. ,   National Medical Research Center of Traumatology and Orthopedics n.a. N.N. Priorov, Moscow, Russian Federation
Published: April 2022

The objective was to determine most common pathogens causing periprosthetic joint infection (PJI) of major joints, to identify the tendency to antibiotic resistance over the period from 2015 to 2020. Material and methods Microbiological culture results of 354 patients with PJI of major joints treated at our department were retrospectively analyzed. The spectrum of the leading pathogens causing PJI and the antibacterial resistance were explored and the prevalence of common organisms depending on the type of PJI demonstrated. Results 354 patients were examined and 317 microbial isolates identified. Gram-positive bacteria was isolated in 70.7 % (224 microorganisms) of cases, Gram-negative bacilli isolated in 28.1 % (89 organisms) and Candida sp. identified in 1.2 % (4 isolates). Microbial associations were identified in 15% of cases. Discussion Most common pathogens causing PJI included S. aureus identified in 31.9 %; S. epidermidis, in 20.2 %; E. faecalis, in 8.5 %; P. aeruginosa, in 7.9 %; A. baumannii, in 7.3%. PJI associated MRSE strains increased from 12.1 % to 26.7 % and S. haemolyticus (MR) increased from 2 % to 11.6 %. S. aureus and Gram-negative bacilli were most common for early acute and hematogenous acute PJI. There were no significant differences in the prevalence of S. aureus and S. epidermidis in early/delayed and late chronic PJI. Enterococcus species and Gram-negative bacilli were detected less frequently with PJI. There was an increasing antibiotic resistance of A. baumannii and P. aeruginosa. Vancomycin-resistant strains and linezolid-resistant strains were newly found among Grampositive bacilli and pan drug-resistant A. baumannii strains. Conclusion The six-year microbiological monitoring showed S. aureus, S. epidermidis, P. aeruginosa, and A. baumannii as most common pathogens causing PJI. The growing antibiotic resistance of Gram-positive and Gram-negative bacilli and the increasing role of the latter in the pathogenesis of early acute PJI require changes in empirical antibiotic therapy regimens.
Monitoring of the most common gram-positive microflora and its antibiotic sensitivity in persons with chronic osteomyelitis over a three-year period
Authors:   Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation, Shipitsyna I.V. , Osipova E.V. ,   Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation
Published: April 2022

Materials and methods The microbiological study included 5,226 clinical isolates of gram-positive microorganisms belonging to 6 taxa (S. aureus, S. epidermidis, S. saprophyticus, Enterococcus sp., Streptococcus sp., Corynebacterium sp.), detected in the period from 2017 to 2019 in primary cultures from wounds and fistulas of 5,116 patients with chronic osteomyelitis who were treated in the purulent department of our bone infection clinic. Results and its discussion According to our study, S. aureus strains are most common g gram-positive microflora in chronic osteomyelitis, taking the first place in terms of occurrence over a three-year period. The rate of isolation of methicillin-resistant strains of S. aureus (MRSA) over three years was 17.3 ± 1.9 %. In 2019, the occurrence of S. epidermidis strains increased by 28 % compared to 2017, while the number of isolated MRSE remained within 57.2 ± 1.8 %. The analysis of antibiotic patterns showed a tendency to an increase in the number of multi-resistant strains of Staphylococcus sp. Monitoring of the gram-positive microflora in chronic osteomyelitis revealed an insignificant isolation of the bacteria of the genus Enterococcus and Streptococcus (9– 10 % of cases). The most effective against Enterococcus strains were glycopeptides and aminopenicillins, the least effective against strains of Enterococcus were quinolones and aminoglycosides. The most effective drugs against Streptococcus sp. were levofloxacin and clindamycin. The occurrence of bacteria of the genus Corynebacterium sp. was within 3–4 %. The least effective drugs against Corynebacterium sp. were clindamycin, gentamicin, and ciprofloxacin. The strains were susceptible to tetracycline drugs, penicillins, macrolides and rifampicin. Conclusions Considering that gram-positive microorganisms are primary pathogens in the etiology of chronic osteomyelitis, microbiological monitoring of the leading pathogens of the disease and their resistance enables to identify ineffective antibacterial drugs, optimize treatment, and thereby reduce the rate of poor outcomes in the management of the disease.
Conservative treatment of avascular necrosis of the femoral head (literature review)
Authors:   Peoples’ Friendship University of Russia, Moscow, Russian Federation, Panin M.A. , Boiko A.V. ,   Peoples’ Friendship University of Russia, Moscow, Russian Federation, Abakirov M. Dzh. ,   Peoples’ Friendship University of Russia, Moscow, Russian Federation, Petrosyan A.S. ,   City Clinical Hospital № 17, Moscow, Russian Federation, Ananin D.A. ,   Peoples’ Friendship University of Russia, Moscow, Russian Federation, Awad M.M. ,   Peoples’ Friendship University of Russia, Moscow, Russian Federation
Published: April 2022

Introduction Avascular necrosis of the femoral head is a debilitating disease affecting people of working age and having an important medical and social role. Total hip arthroplasty is the only effective treatment for late stages of necrosis. Various joint-preserving operations and non-surgical methods can be successfully used for less severe types. There is no unequivocal opinion on the effectiveness of various conservative treatments offered for avascular necrosis of the femoral head. The aim was to summarize data on the role of medications and physiotherapy in treatment of avascular necrosis of the femoral head through the analysis of the modern world literature. Material and methods The original literature search was conducted on key resources including elibrary, PubMed and ResearchGate. Results Outcomes of avascular necrosis of the femoral head treated conservatively were overviewed. The effectiveness of various treatments using bisphosphonates, anticoagulants, statins, prostacyclin derivatives was evaluated. Physiotherapy with shock wave therapy, pulsating electromagnetic fields, and hyperbaric oxygenation was also reviewed. Conservative treatment is reported to be effective only for early (pre-collapse) stages of avascular necrosis of the femoral head. Conclusions A conservative treatment used as a monotherapy for AVN cannot be assessed as a standalone procedure because various combinations of comprehensive treatment are used for the majority of patients. There are no studies in the literature comparing the effectiveness of conservative therapies using iloprost and statins, bisphosphonates and anticoagulants, shockwave and hyperbaric oxygen therapy in homogeneous patient samples. A deeper study of the underlying pathogenesis of avascular necrosis of the femoral head is required to develop personalized treatment strategies.