bluuebunny/crossref_metadata_2025 huggingface dataset:
Combustion models for shock-induced cloud ignition of aluminium particles using smoothed particle hydrodynamics
Authors: Omang M. , Hauge K. O. , Trulsen J. K.
Published: October 2023

The present work is a numerical follow-up on our published experimental paper on shock ignition of aluminium particle clouds in the low-temperature regime. The in-house multi-phase regularized smoothed particle hydrodynamics (MP-RSPH) code is used to perform numerical simulations with an increasing degree of complexity, looking at single-phase, inert, and reactive particles in separate simulations. The first part of the paper gives a short description of the additional physics added to the code. Based on the experimental results, the numerical code is then used to estimate the particle temperature at the time of ignition. Results from simulations with three different numerical descriptions, the diffusive, kinetic, and total burn rates, are then compared to the experimental results. The two diffusive burn rate simulations (K &H and O &H) show the best fit to the experimental results. The burn rate formula based on our experimental data (O &H) is preferred, since it has the gas temperature dependency included and does not require additional parameter adjustments. The results from the numerical simulations support the theory that the observed aluminium particle cloud burning process is diffusive, as indicated in the experimental paper.
A comparison of explosively driven shock wave radius versus time scaling approaches
Authors: Hargather M. J. , Winter K. O. , Kimberley J. , Wei T.
Published: October 2023

Explosively driven shock wave radius versus time profiles are frequently used to document energy release and relative explosive performance. Recently, two universal shock wave radius versus time profiles have been presented in the literature, which demonstrate the ability to represent explosively driven shock wave profiles for all explosive sources in any fluid environment. These two universal shock wave profiles are examined here relative to each other and relative to a commonly used nonlinear shock wave profile, which is fit to experimental data for individual explosive materials. The nonlinear profile, originally developed by Dewey, is examined here, and a universal non-dimensional form of the equation is proposed. The universal shock wave profiles are all found to be relatively similar, but with slight variations in a transition region of non-dimensional radii $$0.15\lesssim R^*\lesssim 2$$

0.15
≲

R
∗

≲
2

. The variations in this region result in different estimations of energy release or blast strength between the curve fits.
Two new pygmy squids, Idiosepius kijimuna n. sp. and Kodama jujutsu n. gen., n. sp. (Cephalopoda: Idiosepiidae) from the Ryukyu Islands, Japan
Authors: Reid Amanda , Sato Noriyosi , Jolly Jeffrey , Strugnell Jan
Published: October 2023

Two new pygmy squid from the Ryukyu archipelago, Japan, are described: Kodama jujutsu, n. gen., n. sp. and Idiosepius kijimuna, n. sp. They differ from all other nominal species in a combination of traits, including the number of tentacular club suckers, shape of the funnel-mantle locking-cartilage, modification of the male hectocotylus and the structure of the gladius and nuchal-locking cartilage, in addition to mitochondrial DNA markers (12S, 16S and COI). They are both known from Okinawa Island and there is some overlap in their distributions. In a molecular phylogeny that includes all nominal Idiosepiidae, Kodama jujutsu, n. gen., n. sp. is sister taxon to a clade containing Xipholeptos Reid & Strugnell, 2018 and Idiosepius Steenstrup, 1881. Xipholeptos and Idiosepius are sister taxa. Idiosepius spp. now includes seven nominal species. In addition, aspects of the behaviour of the new species are described.
Buprenorphine plasma and cerebrospinal fluid concentrations in osteoarthritis patients during low-dose transdermal patch dosing
Authors: Härkänen Lasse , Hakomäki Henriikka , Huopio Jukka , Kokki Hannu , Korhonen Sanni , Lehtonen Marko , Sjövall Sari , Kokki Merja
Published: October 2023

Methods

Fifty-six (56) patients scheduled for arthroplasty, received 7-day extended-release buprenorphine transdermal patches (5 µg/h) for five consecutive weeks, starting two weeks prior to the surgery. Simultaneous plasma and cerebrospinal fluid (CSF) samples were collected during spinal anesthesia.

Results

Median buprenorphine plasma and CSF concentrations at steady-state were 54 pg/mL (range 8.6 – 167 pg/mL) and 1.6 pg/mL (0.30 – 7.3 pg/mL), respectively. The median CSF/plasma -ratio was 3% (range 0.35 – 16%). Large between-subject variability was observed in the measured buprenorphine concentrations within the study population.
Wild Mountain reindeer Rangifer tarandus tarandus winter foraging: snow-free areas a key resource for feeding
Authors: Holtan Marijanne , Strand Olav , Kastdalen Leif , Bjerketvedt Dag K. , Odland Arvid , Pape Roland , Heggenes Jan
Published: October 2023

In a landscape with patchily distributed forage resources, an animal’s distribution may reflect the distribution of the resources if the population is forage-limited in time or space. This may be particularly explicit in climatically extreme and seasonally variable environments, notably alpine and polar environments during winter. Sustainable management considers the amount of available alpine ground lichen in winter as a predictor of carrying capacity for the last remaining populations of wild European Mountain reindeer Rangifer tarandus tarandus in alpine environments in South Norway. Ground lichen growth is constrained to elevated, wind-blown, snow-free ridges. However, wild Mountain reindeer also persist in areas providing little lichen resources. Our alternative functional hypothesis is that the critical resource is the amount of snow-free feeding areas during winter, which provide direct access to forage, likely to be energy-profitable regardless of the type of vegetation. We sampled animal-borne videos from wild Mountain reindeer during maximum accumulation of snow in late winter/spring, in three contrasting areas providing variable amounts of ground lichen and alternative vegetation resources. Direct observations of reindeer foraging via videos document an active selection and strong preference for feeding on snow-free patches, regardless of type of vegetation. Active ‘cratering’ in snow was not observed. In contrast, walking behaviours occurred much more frequently across snow-covered areas. Remote sensing data and analyses corroborated these observations. In the sustainable management of wild Mountain reindeer amounts of vegetated snow-free areas is an important functional predictor of winter carrying capacity.
Continuous glucose monitoring metrics following sub-Tenon’s injection of triamcinolone acetonide for diabetic macular edema
Authors: Sotani-Ogawa Rei , Kusuhara Sentaro , Hirota Yushi , Kim Kyung Woo , Matsumiya Wataru , Ogawa Wataru , Nakamura Makoto
Published: October 2023

Purpose

This pilot study aims to comprehensively evaluate the effects of sub-Tenon’s injection of triamcinolone acetonide (STTA) on glycemic control in patients with diabetic macular edema (DME) using professional continuous glucose monitoring (CGM).

Methods

This retrospective study analyzed changes in glycemic control in 20 patients with type 2 mellitus and DME following single STTA (20 mg/0.5 mL) using The FreeStyle Libre Pro system. Professional CGM provides core CGM metrics such as the percentage of time that glucose levels fall within a target range and include the time in range (TIR) (70–180 mg/dL), time above range (TAR) (> 180 mg/dL), and time below range (TBR) (< 70 mg/dL). Outcome measures were the changes in CGM metrics (TIR, TAR and TBR) and the percentage of patients in whom TAR increased by at least 10 percentage points (ppt) 4 days before to 4 days after STTA administration.

Results

The mean CGM metrics (TIR/TAR/TBR) were 75.5%/19.9%/4.4% 4 days before STTA and 73.7%/22.4%/3.5% 4 days after STTA; the metrics 4 days before and 4 days after STTA were not significantly different (P = 0.625 for TIR, P = 0.250 for TAR, and P = 0.375 for TBR). TAR increased by more than 10 ppt in four (20%) patients treated with sulfonylurea and/or insulin.

Conclusion

Although there were no significant changes in the CGM metrics, four patients developed CGM-measured hyperglycemia after STTA for DME.
Novel therapeutic perspectives in Noonan syndrome and RASopathies
Authors: Saint-Laurent Céline , Mazeyrie Laurène , Yart Armelle , Edouard Thomas
Published: October 2023

Noonan syndrome belongs to the family of RASopathies, a group of multiple congenital anomaly disorders caused by pathogenic variants in genes encoding components or regulators of the RAS/mitogen-activated protein kinase (MAPK) signalling pathway. Collectively, all these pathogenic variants lead to increased RAS/MAPK activation. The better understanding of the molecular mechanisms underlying the different manifestations of NS and RASopathies has led to the identification of molecular targets for specific pharmacological interventions. Many specific agents (e.g. SHP2 and MEK inhibitors) have already been developed for the treatment of RAS/MAPK-driven malignancies. In addition, other molecules with the property of modulating RAS/MAPK activation are indicated in non-malignant diseases (e.g. C-type natriuretic peptide analogues in achondroplasia or statins in hypercholesterolemia).

  Conclusion: Drug repositioning of these molecules represents a challenging approach to treat or prevent medical complications associated with RASopathies.

What is Known:• Noonan syndrome and related disorders are caused by pathogenic variants in genes encoding components or regulators of the RAS/mitogen-activated protein kinase (MAPK) signalling pathway, resulting in increased activation of this pathway.• This group of disorders is now known as RASopathies and represents one of the largest groups of multiple congenital anomaly diseases known.

What is New:• The identification of pathophysiological mechanisms provides new insights into the development of specific therapeutic strategies, in particular treatment aimed at reducing RAS/MAPK hyperactivation.• Drug repositioning of specific agents already developed for the treatment of malignant (e.g. SHP2 and MEK inhibitors) or non-malignant diseases (e.g. C-type natriuretic peptide analogues in achondroplasia or statins in hypercholesterolaemia) represents a challenging approach to the treatment of RASopathies.
The inter-familiar issues of Greek parents facing childhood cancer
Authors: Nizamis Kleanthis , Kalliakmanis Vassilios , Koutsoupias Nikos , Polychronopoulou Sophia , Baka Margarita , Papakonstantinou Evgenia , Hatzipantelis Emmanouil
Published: October 2023

Cancer as a whole, but especially childhood cancer, creates a number of psychological, social, and family problems as well as practical and financial issues, which every parent is called upon to solve. This study focuses on childhood cancer and aims at a thorough analysis of the physical/organic, psychological, and social problems associated with the parents and relatives of a child with cancer. The special element in pediatric neoplasms is not only the vulnerable population target group, but also the set of secondary effects it has on the environment of the sick child. The research was conducted on a sample of 133 families of children with cancer, and the results were displayed after statistical processing and data analysis with R statistical software. The results of the study confirm with statistically significant data the effect of childhood cancer on the physical, mental, and social health and behavior of the parent. Thus, 53.8% of the respondents stated 5 and above on the 7-point Likert scale for fatigue issues, 55.6% for sleep disorders, 78.1% for stress, and 82.7% for fear. The key findings are characterized by high specificity as it is a unique study that reveals particular aspects of the Greek parent’s behavior, mind, and body during the period of their child’s illness.

   Conclusion: The effects of childhood illnesses, particularly when they are severe, such as neoplasms, present a looming threat, ushering in a multitude of adverse alterations in the daily lives of the affected child's family.

What is Known – What is New:• We know the effects that a childhood illness brings not only to the sick child, but also to the entire family circle. The new element in the present research is that these data reflect the situation in Greece, for which the research data in this area is quite limited. Our research is one of the few studies that demonstrate with statistical data the change in the psychosomatic health of the parent who has a child with cancer.
Evaluation of the safety profile and therapeutic efficacy of remdesivir in children with SARS-CoV-2 infection – a single-center, retrospective, cohort study
Authors: Kautsch Karolina , Wiśniowska Joanna , Friedman-Gruszczyńska Joanna , Buda Piotr
Published: October 2023

Despite 3.5 years of the SARS-CoV-2 pandemic, we still lack effective drugs against COVID-19. The first and most widely used drug, remdesivir, has not yet been shown to be effective in adults. Even less is known about its effectiveness in children. Therefore, the aim of this retrospective study was to evaluate the safety and efficacy of remdesivir in pediatric patients with COVID-19 hospitalized in one medical center. The medical records of 328 children with COVID-19 were analyzed. Analysis was performed on the subgroups of children treated and not treated with remdesivir. Clinical data on general health, course of COVID-19 and treatment received were analyzed. Remdesivir was administered to 64 children, 16 to treat severe or critical illness and 48 because of the presence of risk factors to prevent progression to severe COVID-19. In children with severe COVID-19, remdesivir did not reduce the mortality rate. However, in patients with milder disease and risk factors, the drug significantly reduced the risk of progression to severe disease. Among adverse events, only mild aminotransferase elevations were observed in 4 patients, but none of these required discontinuation of treatment.

Conclusions: Remdesivir is a safe treatment option for children with COVID-19. However, the efficacy of this therapy is still uncertain. It appears that in children with asymptomatic to moderate COVID-19 and risk factors for severe disease, remdesivir could be an effective method of prophylaxis. However, its efficacy in controlling severe disease is questionable and requires further study.

What is Known:• There are still no effective drugs to combat COVID-19, and the efficacy of the widely used remdesivir in adults is controversial.• All recommendations and guidelines on the use of remdesivir in the pediatric population are based mainly on clinical trials in adults.

What is New:• Remdesivir is a safe treatment for COVID-19 in the pediatric population.• In children with asymptomatic to moderate COVID-19 and risk factors for severe disease, remdesivir could be an effective drug to prevent disease progression. However, its efficacy in treating severe disease in children needs further exploration.
Surface fractures generated during the 2021 Reykjanes oblique rifting event (SW Iceland)
Authors: Bufféral Simon , Panza Elisabetta , Mannini Stefano , Hjartardóttir Ásta Rut , Nobile Adriano , Gies Nils , Óskarsson Birgir Vilhelm , Ruch Joël
Published: October 2023

We use a comprehensive dataset of field observations, high spatial resolution drone orthomosaics and digital terrain models (DTMs) to map, quantify and characterize the extensive ground fracturing related to the 2021 seismo-tectonic and volcanic activity in the Reykjanes Peninsula (Iceland). The dataset, spans an area of about 30 km$$^2$$

2

, where we map nearly 20 000 ground cracks with metric to decametric lengths and centimetric extensional offsets, revealing a dominant dextral shear, in agreement with published seismic data. Although striking in a direction similar to the volcanic systems in the Reykjanes Peninsula (N030–040), most fractures appear as en-échelon structures globally aligned along N-S-striking fault zones up to 3–4 km long. By examining the timing of ground fracturing through repeated field observations, seismic data and InSAR images, we associate a fracture zone with most earthquakes of M$$_\omega \ge 5.0$$

ω

≥
5.0

that occurred in the month preceding the March 2021 Fagradalsfjall eruption. We describe three preexisting N-S fault zones, with fault segments that were reactivated up to three times during the pre-eruptive seismic activity, while the magma intrusion did not trigger graben-related ground fractures typically observed during magmatic injections. Our depiction of a system dominated by strike-slip tectonic features helps in understanding the geometry and bookshelf-mode of tectonic activity along a diffuse and highly oblique extensional plate boundary. Evidence of transient fracturing is typically quickly lost because of erosion or lava flow burial, highlighting a potential under-representation of diffuse fracturing when studying old tectonic and volcanic systems.
Nonlinear GARCH-type models for ordinal time series
Authors: Jahn Malte , Weiß Christian H.
Published: October 2023

Despite their relevance in various areas of application, only few stochastic models for ordinal time series are discussed in the literature. To allow for a flexible serial dependence structure, different ordinal GARCH-type models are proposed, which can handle nonlinear dependence as well as kinds of an intensified memory. The (logistic) ordinal GARCH model accounts for the natural order among the categories by relying on the conditional cumulative distributions. As an alternative, a conditionally multinomial model is developed which uses the softmax response function. The resulting softmax GARCH model incorporates the ordinal information by considering the past (expected) categories. It is shown that this latter model is easily combined with an artificial neural network response function. This introduces great flexibility into the resulting neural softmax GARCH model, which turns out to be beneficial in three real-world time series applications (air quality levels, fear states, cloud coverage).
Zinc oxide-ozonated olive oil as a new root canal filling material in primary molars: a clinical randomized controlled trial
Authors: EL-Desouky Shaimaa S. , Omer Shaimaa M. Mahfouz , Ghouraba Rehab F. , Latif Reham M. Ali Abdel , Kabbash Ibrahim A. , Hadwa Shimaa M.
Published: October 2023

Objectives

The complex root canal anatomy of primary teeth keeps it very tricky to attain appropriate cleansing by biomechanical instrumentation, so obtaining an obturating material with excellent antimicrobial properties is a challenge in current clinical pulpectomy practice. So, this study aimed to assess the clinical and radiographic performance of zinc oxide-ozonated olive oil as a primary root canal filling material.

Materials and methods

Ninety non-vital primary molars in children ranging from 4 to 8 years were allocated into three groups in which root canals were filled with zinc oxide-ozonated olive oil, zinc oxide-olive oil, and zinc oxide-eugenol (ZOE) according to each group after pulpectomy procedure. Clinical and radiographic evaluations were done at 3-, 6-, and 12-month follow-up periods. Statistical analysis was performed for the collected data.

Results

All study groups showed a significant improvement regarding clinical signs and symptoms during follow-up periods. Ozonated-olive oil group revealed a significant increase in furcation radiodensity and a decrease in periodontal ligament space at 3-, 6-, and 12-month follow-up intervals compared to other groups.

Conclusion

Zinc oxide-ozonated olive oil and zinc oxide-olive oil paste had shown good clinical and radiographic success for primary teeth pulpectomy.

Clinical relevance

The intricate torturous primary root canal anatomy, in addition to the child’s negative behavior, interferes with the complete debridement, so the long-lasting antibacterial effect of the primary root canal filling material aids in the pulpectomy success.
Hoarding titmice predominantly use Familiarity, and not Recollection, when remembering cache locations
Authors: Smulders Tom V. , Douglas Laura J. , Reza Daniel , Male Lucinda H. , Prysce Alexander , Alix Amélie , de Guzman Dodd Alexander , Read Jenny C. A.
Published: October 2023

Scatter-hoarding birds find their caches using spatial memory and have an enlarged hippocampus. Finding a cache site could be achieved using either Recollection (a discrete recalling of previously experienced information) or Familiarity (a feeling of “having encountered something before”). In humans, these two processes can be distinguished using receiver operating characteristic (ROC) curves. ROC curves for olfactory memory in rats have shown the hippocampus is involved in Recollection, but not Familiarity. We test the hypothesis that food-hoarding birds, having a larger hippocampus, primarily use Recollection to find their caches. We validate a novel method of constructing ROC curves in humans and apply this method to cache retrieval by coal tits (Periparus ater). Both humans and birds mainly use Familiarity in finding their caches, with lower contribution of Recollection. This contribution is not significantly different from chance in birds, but a small contribution cannot be ruled out. Memory performance decreases with increasing retention interval in birds. The ecology of food-hoarding Parids makes it plausible that they mainly use Familiarity in the memory for caches. The larger hippocampus could be related to associating cache contents and temporal context with cache locations, rather than Recollection of the spatial information itself.
Mitochondria-related lncRNAs: predicting prognosis, tumor microenvironment and treatment response in lung adenocarcinoma
Authors: Zhou Qianhui , Xiong Jiali , Gao Yan , Yi Rong , Xu Yuzhu , Chen Quefei , Wang Lin , Chen Ying
Published: October 2023

Lung cancer is the most common type of malignant tumor that affects people in China and even across the globe, as it exhibits the highest rates of morbidity and mortality. Lung adenocarcinoma (LUAD) is a type of lung cancer with a very high incidence. The purpose of this study was to identify potential biomarkers that could be used to forecast the prognosis and improve the existing therapy options for treating LUAD. Clinical and RNA sequencing data of LUAD patients were retrieved from the TCGA database, while the mitochondria-associated gene sets were acquired from the MITOMAP database. Thereafter, Pearson correlation analysis was carried out to screen mitochondria-associated lncRNAs. Furthermore, univariate Cox and Lasso regression analyses were used for the initial screening of the target lncRNAs for prognostic lncRNAs before they could be incorporated into a multivariate Cox Hazard ratio model. Then, the clinical data, concordance index, Kaplan–Meier (K-M) curves, and the clinically-relevant subjects that were approved by the Characteristic Curves (ROC) were employed for assessing the model's predictive value. Additionally, the differences in immune-related functions and biological pathway enrichment between high- and low-risk LUAD groups were examined. Nomograms were developed to anticipate the OS rates of the patients within 1-, 3-, and 5 years, and the differences in drug sensitivity and immunological checkpoints were compared. In this study, 2175 mitochondria-associated lncRNAs were screened. Univariate, multivariate, and Lasso Cox regression analyses were carried out to select 13 lncRNAs with an independent prognostic significance, and a prognostic model was developed. The OS analysis of the established prognostic prediction model revealed significant variations between the high- and low-risk patients. The AUC-ROC values after 1, 3, and 5 years were seen to be 0.746, 0.692, and 0.726, respectively. The results suggested that the prognostic model riskscore could be used as an independent prognostic factor that differed from the other clinical characteristics. After analyzing the findings of the study, it was noted that both the risk groups showed significant differences in their immune functioning, immunological checkpoint genes, and drug sensitivity. The prognosis of patients with LUAD could be accurately and independently predicted using a risk prediction model that included 13 mitochondria-associated lncRNAs.
Reinforcement learning for shared autonomy drone landings
Authors: Backman Kal , Kulić Dana , Chung Hoam
Published: October 2023

Novice pilots find it difficult to operate and land unmanned aerial vehicles (UAVs), due to the complex UAV dynamics, challenges in depth perception, lack of expertise with the control interface and additional disturbances from the ground effect. Therefore we propose a shared autonomy approach to assist pilots in safely landing a UAV under conditions where depth perception is difficult and safe landing zones are limited. Our approach is comprised of two modules: a perception module that encodes information onto a compressed latent representation using two RGB-D cameras and a policy module that is trained with the reinforcement learning algorithm TD3 to discern the pilot’s intent and to provide control inputs that augment the user’s input to safely land the UAV. The policy module is trained in simulation using a population of simulated users. Simulated users are sampled from a parametric model with four parameters, which model a pilot’s tendency to conform to the assistant, proficiency, aggressiveness and speed. We conduct a user study ($$n=28$$

n
=
28

) where human participants were tasked with landing a physical UAV on one of several platforms under challenging viewing conditions. The assistant, trained with only simulated user data, improved task success rate from 51.4 to 98.2% despite being unaware of the human participants’ goal or the structure of the environment a priori. With the proposed assistant, regardless of prior piloting experience, participants performed with a proficiency greater than the most experienced unassisted participants.
Seismic risk-informed prioritisation of multi-span RC girder bridges considering knowledge-based uncertainty
Authors: Nettis Andrea , Raffaele Domenico , Uva Giuseppina
Published: October 2023

In earthquake-prone countries, transport network managers need to perform extensive seismic risk assessments coping with a considerable number of bridges characterised by an unsatisfying knowledge level and designed in the past without anti-seismic requirements. This study proposes a framework for efficient risk assessment of multi-span girder bridges considering knowledge-based uncertainties. The framework is intended to be applied to risk-informed prioritisation of bridge portfolios. It is based on subsequent modules that involve the input of knowledge data, the simulation of knowledge-based uncertainties, simplified seismic analysis, fragility and loss assessment. The seismic vulnerability of a given bridge is represented by loss ratio percentiles related to a given seismic intensity measure which can be used to quantify the expected annual losses and the corresponding variability due to the influence of knowledge-based uncertainty. A case-study section demonstrates the framework for the widespread category of simply supported girder-reinforced concrete bridges. It addresses issues such as the use of optimal intensity measures, the required number of model realisations and discrepancies with respect to accurate nonlinear time-history analysis. Finally, an illustrative example of the proposed framework for eight case-study bridges in Southern Italy demonstrates its applicability for seismic risk-informed prioritisation of critical bridges and for directing in-depth knowledge data collections where needed.
Dissolved polycyclic aromatic compounds in Canada’s Athabasca River in relation to Oil Sands from 2013 through 2019
Authors: Lévesque Lucie M. J. , Roy Julie , Glozier Nancy E. , Dirk Leah , Cooke Colin A.
Published: October 2023

The Canada-Alberta Oil Sands Monitoring (OSM) Program began long-term surface water quality monitoring on the lower Athabasca River in 2012. Sampling of low level, bio-accumulative polycyclic aromatic compounds (PACs) targeted a suite of parent and alkylated compounds in the Athabasca River (AR) mainstem using semi-permeable membrane devices (SPMDs). Samples were collected along a gradient from upstream reference near Athabasca, Alberta, through exposure to the Athabasca oil sands deposit (AOSD), various tributary inflows, and mining activities within the OSMA, to downstream recovery near Wood Buffalo National Park (WBNP) and reference on the Slave River. The program adapted over the years, shifting in response to program review and environmental events. The AOSD chemical fingerprint was present in samples collected within the AOSD, through the oil sands mineable area (OSMA), downstream to recovery from 2013 to 2019. PACs were dominated by alkylated phenanthrenes/anthracenes (PAs) and dibenzothiophenes (Ds), with elevated levels of alkylated fluorenes (Fs), naphthalenes (Ns), fluoranthenes/pyrenes (FlPys) and benzo[a]anthracenes/chrysenes (BaACs), increasing in concentration from C1 < C2 < C3 < C4. Concentrations of these petrogenic PACs were at their highest within the OSMA and downstream of tributaries. The AOSD fingerprint was absent from sites located outside of the influence of the AOSD and downstream of the Peace-Athabasca Delta on the Slave River. PAC concentrations in the AR increased with mainstem discharge and loadings from tributaries, were moderated by the PAD, and diluted by the Peace River. This work bolsters the baseline PAC information previously reported for the Athabasca River and waters downstream, reporting 7 years of data, from all sites within the mainstem monitoring program, and exploring potential regional and hydrological drivers of these between sites and over time.
Do male reproductive traits evolve at the intraspecific level in response to the amount of placentotrophy in a genus of viviparous fishes?
Authors: Domínguez-Castanedo Omar , Suárez-Rodríguez Monserrat , Solano-Zavaleta Israel , Zúñiga-Vega J. Jaime
Published: October 2023

Placentotrophy is a particular type of maternal provisioning to developing embryos, in which mothers actively provide nutrients via complex placental structures. Placentotrophy implies less pre-fertilization investment, resulting in a shift from pre- to post-copulatory sexual selection. This change can potentially result in a conflict between females and males. This phenomenon has been demonstrated at the interspecific level in viviparous fishes of the family Poeciliidae, in which males of species that lack placentotrophy have evolved traits related to pre-copulatory sexual selection such as coloration, ornaments, and courtship behavior. Placentotrophic species, on the other hand, have evolved traits associated with post-copulatory sexual selection such as long intromittent organs (gonopodium) and increased sexual coercion behavior. Here we test, for the first time at the intraspecific level, whether there is a similar relationship between a higher degree of female placentotrophy and the evolution of male reproductive traits (larger testes and longer gonopodia) in three species of the genus Poeciliopsis (P. gracilis, P. infans, and P. prolifica). We observed a tendency towards longer gonopodia in males of P. gracilis as well as the largest testes of P. prolifica males in the populations with the highest degrees of placentotrophy. However, the statistical support for these findings was relatively weak. Therefore, we failed to support the hypothesis of a selective effect of female placentotrophy on male gonads and genitalia. We discuss other evolutionary forces that may have driven the observed intraspecific variation in male reproductive traits of Poeciliopsis fishes.
Fibroblast Growth Factor 21 Relieves Lipopolysaccharide-Induced Acute Lung Injury by Suppressing JAK2/STAT3 Signaling Pathway
Authors: Cai Mengsi , Ye Huihui , Zhu Xiayan , Li Xiuchun , Cai Luqiong , Jin Jiajia , Chen Qiwen , Shi Yuzhe , Yang Lehe , Wang Liangxing , Huang Xiaoying
Published: October 2023

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening disease without an effective drug at present. Fibroblast growth factor 21 (FGF21) was reported to be protective against inflammation in metabolic disease in recent studies. However, the role of FGF21 in ALI has been rarely investigated. In this study, it was found that the expression of FGF21 was markedly increased in lung tissue under lipopolysaccharide (LPS) stimulation in vivo, whereas it was decreased in lung epithelial cells under LPS stimulation in vitro. Therefore, our research aimed to elucidate the potential role of FGF21 in LPS-induced ALI and to detect possible underlying mechanisms. The results revealed that the deficiency of FGF21 aggravated pathological damage, inflammatory infiltration, and pulmonary function in LPS-induced ALI, while exogenous administration of FGF21 improved these manifestations. Moreover, through RNA sequencing and enrichment analysis, it was unveiled that FGF21 might play a protective role in LPS-induced ALI via JAK2/STAT3 signaling pathway. The therapeutic effect of FGF21 was weakened after additional usage of JAK2 activator in vivo. Further investigation revealed that FGF21 significantly inhibited STAT3 phosphorylation and impaired the nuclear translocation of STAT3 in vitro. In addition, the aggravation of inflammation caused by silencing FGF21 can be alleviated by JAK2 inhibitor in vitro. Collectively, these findings unveil a potent protective effect of FGF21 against LPS-induced ALI by inhibiting the JAK2/STAT3 pathway, implying that FGF21 might be a novel and effective therapy for ALI.
Depth-based Sampling and Steering Constraints for Memoryless Local Planners
Authors: Nguyen Binh T. , Nguyen Linh , Choudhury Tanveer A. , Keogh Kathleen , Murshed Manzur
Published: October 2023

By utilizing only depth information, the paper introduces a novel two-stage planning approach that enhances computational efficiency and planning performances for memoryless local planners. First, a depth-based sampling technique is proposed to identify and eliminate a specific type of in-collision trajectories among sampled candidates. Specifically, all trajectories that have obscured endpoints are found through querying the depth values and will then be excluded from the sampled set, which can significantly reduce the computational workload required in collision checking. Subsequently, we apply a tailored local planning algorithm that employs a direction cost function and a depth-based steering mechanism to prevent the robot from being trapped in local minima. Our planning algorithm is theoretically proven to be complete in convex obstacle scenarios. To validate the effectiveness of our DEpth-based both Sampling and Steering (DESS) approaches, we conducted experiments in simulated environments where a quadrotor flew through cluttered regions with multiple various-sized obstacles. The experimental results show that DESS significantly reduces computation time in local planning compared to the uniform sampling method, resulting in the planned trajectory with a lower minimized cost. More importantly, our success rates for navigation to different destinations in testing scenarios are improved considerably compared to the fixed-yawing approach.
SOME REMARKS ON SOBOLEV AND BI-SOBOLEV MAPPINGS
Authors: D’Onofrio Luigi , Molica Bisci Giovanni
Published: October 2023

In this note, we present the state-of-the-art theory of bi-Sobolev mappings. We recall that f is a Sobolev homeomorphism if f belongs to $$W^{1,1}_\text {loc}\cap \textrm{Hom}(\Omega ; \Omega ')$$

W
loc

1
,
1

∩
Hom

(
Ω
;

Ω
′

)

, and f is a bi-Sobolev map if and only if f and $$f^{-1}$$

f

-
1

are Sobolev homeomorphisms. This concept, introduced in Hencl et al. (J. Math. Anal. Appl. 355, 22–32 2009), plays a central role in Geometric Function Theory. For instance, we just mention here that maps of bi-Sobolev type are strictly related to the notion of mappings of finite distortion; see, among others, the papers (Hencl and Koskela 2014) Pratelli (Nonlinear Anal. 154, 258–268  2017).
Communications Infrastructure, Technological Solutionism and the International Legal Imagination
Authors: Joyce Daniel
Published: October 2023

This article considers the role played by communications infrastructure within the international legal imagination. It engages with contemporary debates regarding the power of corporate digital platforms and their model of information capitalism. An international legal historical perspective is adopted in order to contextualise international law’s present infrastructural turn and connect current debates over big tech with their precursors. The history of international legal engagement with the development of communications infrastructure reveals a recurring pattern of looking to technological infrastructure for solutions to global problems. This can act to empower private actors and contribute to an ongoing absence of meaningful international legal regulation of communications. The contemporary interest in infrastructure, and its implications in terms of fostering the private power of big tech over global communications, is in many ways a return. But it could also take account of alternative visions for international law which were present at key moments during the League of Nations era and the Cold War. Connecting current debates with those earlier moments in international legal history can help to highlight and counter continuing patterns of technological solutionism within the international legal imagination.
Telomere maintenance mechanism subtype reveals different immune activity in vestibular schwannoma
Authors: Sung Ji-Yong , Lee Jung Woo
Published: October 2023

Background

The immortality of cancer cells relies on maintaining the length of telomeres, which prevents cellular senescence and enables unlimited replication. However, little is currently known about telomerase activity and the alternative lengthening of telomeres (ALT) in vestibular schwannomas. In this study we aimed to elucidate the role that telomerase and ALTs play in vestibular schwannomas.

Methods

To address this gap, we conducted a study where we used the gene set variation analysis algorithm with bulk RNA-seq and single-cell RNA-seq to identify the characteristics of each group of patients with vestibular schwannomas, based on their telomere maintenance mechanism subtype.

Results

Our findings suggest that patients with relatively high ALT-like groups have a better prognosis than those with relatively high telomerase groups. Specifically, we found that the high telomerase group had relatively higher antigen-presenting cell (APC) activity than the high ALT like group. At the single-cell level, microglia, neutrophils, and fibroblasts showed high telomerase activity and relatively high APC activity compared to other cell types. In addition, Schwann cells in the group with low ALT levels exhibited elevated immune activity at the single-cell level.

Conclusion

These results suggest that personalized drug therapy could be developed from the perspective of precision medicine for patients with relatively high telomerase activity and a high ALT-like group.
A saturated stochastic simulator: synthetic US Gulf coast tropical cyclone precipitation fields
Authors: Nakamura Jennifer , Lall Upmanu , Kushnir Yochanan , Harr Patrick A.
Published: October 2023

The space–time fields of rainfall during a hurricane and tropical storm (TC) landfall are critical for coastal flood risk preparedness, assessment, and mitigation. We present an approach for the stochastic simulation of rainfall fields that leverages observed, high-resolution spatial fields of historical landfalling TCs rainfall that is derived from multiple instrumental and remote sensing sources, and key variables recorded for historical TCs. Spatial realizations of rainfall at each time step are simulated conditional on the variables representing the ambient conditions. We use 6 hourly precipitation fields of tropical cyclones from 1983 to 2019 that made landfall on the Gulf coast of the US, starting from 24 h before landfall until the end of the track. A conditional K-nearest neighbor method is used to generate the simulations. The TC attributes used for conditioning are the preseason large-scale climate indices, the storm maximum wind speed, minimum central pressure, the latitude and speed of movement of the storm center, and the proportion of storm area over land or ocean. Simulation of rainfall for three hurricanes that are kept out of the sample: Katrina [2005], Rita [2005], and Harvey [2017] are used to evaluate the method. The utility of coupling the approach to a hurricane track simulator applied for a full season is demonstrated by an out-of-sample simulation of the 2020 season.
Enhanced gain Raman amplifiers using different pumping schemes
Authors: Mustafa Fathy M. , Sayed Ahmed F. , Aly Moustafa H. , Elmisery F. A.
Published: October 2023

Raman amplifiers (RAs) can be represented as one of the best solutions for transmission techniques, where they can compensate attenuation and transmit the optical signal to long-haul distances. This work proposes and investigates two cascaded models (multi-stages of RAs) for enhancing the received power and the overall gain. This study includes three fiber types: Dispersion Shifted Fiber, Truewave and Freelight fibers at 100 km distance and pumping powers of 500, 600 and 700 mW. The obtained results reveal that the best results gain is 46.46 dB and the power of output signal is 42.47 dBm achieved at 700 mW pump power with Truewave fiber. The models are compared with previously published work, where the gain and the output signal power are enhanced to more than 66.58–85.84%.
The Application of the Metacognitive Model of Desire Thinking and Craving in Problematic Social Networking Sites Use
Authors: Bocci Benucci Sara , Tonini Benedetta , Roffo Giulia , Casale Silvia , Fioravanti Giulia
Published: October 2023

Cognitive models of addictive behaviours have highlighted the central role of Desire Thinking (DT) – a conscious and voluntary cognitive process orienting to prefigure images and information about a positive target-related experience – in increasing craving and maintaining addictive behaviors. The metacognitive model of DT and craving posits that metacognition plays a central role in understanding dysregulation in DT. The current study aims to test the role of metacognitions about DT, DT, and craving in the relationship between Fear of Missing Out (FoMo), boredom proneness, negative emotional reactivity and Problematic Social Network Sites Use (PSNSU). A sample of 529 participants (Mage= 32.45 ± 13.33; F = 62.9%) completed an online survey. The hypothesised model produced an adequate fit to the data and accounted for 86% of PSNSU variance. FoMO predicted positive metacognitions about DT (PMDT), which predicted DT that, in association with craving, predicted PSNSU. Boredom proneness positively predicted PSNSU directly and indirectly through the serial mediation of PMDT, DT, and craving. A direct path between negative emotional reactivity and PSNSU was found. The current findings provide preliminary evidence for applying the metacognitive model of DT and craving in PSNSU. PMDT and DT may be central cognitive processes in craving and PSNSU for individuals who experience boredom proneness and FoMo.
Meta-analysis of blood indices and production physiology of broiler chickens on dietary fermented cassava intervention
Authors: Ogbuewu I.P. , Mabelebele M. , Mbajiorgu C.A.
Published: October 2023

The effects of dietary fermented cassava on the blood constituents and production parameters of broiler chickens have been reported with variable outcomes. Therefore, this investigation aimed to explore the impacts of dietary fermented cassava on growth traits, blood constituents, visceral organ, and carcass characteristics of broiler chickens. Four databases were searched for studies that assessed responses of broiler chickens dietary fermented cassava. Eleven articles were used for the investigation, and data generated were analysed using OpenMEE software. A random effects model was used, and effect sizes were presented as standardised mean difference (SMD) at a 95 % confidence interval (CI). Sources of heterogeneity were evaluated using the following modifiers: broiler strain used, cassava form, feeding duration, type of microbes used for the fermentation, and inclusion level of cassava. Results indicate that fermented cassava-based diets increased feed intake (SMD = 0.38; 95 % CI: 0.11, 0.65; P = 0.006), feed conversion ratio (SMD = 1.26; 95 % CI: 0.91, 1.61; P < 0.001), white blood cells (SMD = 1.26; 95 % CI: 0.54, 1.98; P < 0.001), total serum protein (SMD = 1.23; 95 % CI: 0.41, 2.05; P = 0.003), serum cholesterol (SMD = 0.43; 95 % CI: 0.01, 0.85; P = 0.050), serum creatinine (SMD = 2.53; 95 % CI: 0.53, 4.53; P = 0.013), and serum uric acid (SMD = 4.33; 95 % CI: 6.25, 2.41; P < 0.001), but lowered average daily gain and carcass yield, taking heterogeneity into account. Results reveal that studied modifiers were responsible for the inconsistent results among authors. In conclusion, dietary fermented cassava negatively influenced carcass yield, growth performance, and aspects of blood indices of broiler chickens, but did not affect abdominal fat content, visceral organ weights, and cut-part weights. However, more innovative research is needed to improve the feeding quality of cassava using other biotechnological tools in order to maximise its potential as an energy source in broiler chickens.
Detection of mecA positive staphylococcal species in a wastewater treatment plant in South Africa
Authors: Oladipo Adegboyega Oyedele , Oladipo Oluwatosin Gbemisola , Bezuidenhout Carlos Cornelius
Published: October 2023

We investigated the prevalence of antibiotic resistant staphylococci and detection of resistant, virulence, and Spa genes in a South African wastewater treatment plant. Species identified were Staphylococcus aureus, S. lentus, S. arlettae, S. cohnii, S. haemolyticus, S. nepalensis, S. sciuri (now Mammaliicoccus sciuri), and S. xylosus. Isolates showed high resistance to methicillin (91%), ampicillin (89%), ciprofloxacin (86%), amoxycillin (80%), ceftazidime (74%), and cloxacillin (71%). Multiple antibiotic resistance (MAR) index for the isolates exceeded 0.2 (0.50–0.70). Among the isolates, 77% were mecA-positive. All S. aureus strains were positive for nuc and 7 Spa gene types. The present study highlights possibility of treated wastewaters being potential reservoir for antibiotic-resistant staphylococci. This is a cause for concern as wastewater effluents are decanted into environmental waters and these are, in many cases, used for various purposes including recreation (full contact), religious (full body submersion), and drinking water for some rural communities and water for livestock.