bluuebunny/crossref_metadata_2025 huggingface dataset:
METHODOLOGICAL FEATURES OF SMARTPHONE SENSORS USING IN PHYSICS SCHOOL LABORATORY WORKSHOP (ON THE EXAMPLE OF THE PHYPHOX MOBILE APPLICATION)
Authors: Voronkin O. S.
Published: November 2022

У статті акцентовано увагу на використанні датчиків смартфону: акселерометра, гіроскопа, магнітометра, датчика освітленості, мікрофона, барометра та інших в учнівських STEM-проєктах. Запропоновано часткове розв’язання проблеми застарілості матеріально-технічної бази шкільних кабінетів фізики через проведення лабораторних робіт у застосунку Phyphox і 3D-друк допоміжних елементів, попередньо розроблених у середовищі моделювання Tinkercad. Phyphox був розроблений в Університеті RWTH Aachen. Застосунок дає змогу на основі даних, що надходять з датчиків смартфону, створити повноцінний лабораторний комплекс і проводити нетривіальні експерименти, а також зберігати масиви даних для подальшої інтерпретації. Визначено такі особливості застосунку Phyphox: наявність готових фізичних експериментів, можливість створення власних експериментів, опрацювання й унаочнення даних із датчиків смартфону в режимі реального часу, підтримка експорту результатів експерименту у файли різних форматів (csv, xls). Phyphox може керуватися дистанційно з будь-якого пристрою, що перебуває в тій самій мережі, що й смартфон, і має веббраузер. Як приклад розглянуто типові фізичні експерименти, що пропонуються у Phyphox, й авторські ініціативи, як-от: встановлення залежності між освітленістю і збільшенням відстані до джерела світла, встановлення закону руху підвісної гойдалки на основі даних акселерометра, визначення ваги пасажира в кабіні рухомого ліфта, встановлення функції, за якою рівень звуку змінюється зі збільшенням відстані від джерела звуку, дослідження резонансних явищ повітря залежно від об’єму порожнини, визначення швидкості руху радіокерованої автомоделі (на прикладі ефекту Доплера). Перспективним напрямом є проведення лабораторних робіт з використанням зовнішніх датчиків, підключених до платформ Arduino, із синхронізацією зі смартфоном через Bluetooth, що потребує подальших навчально-методичних розробок.
TRANSDISCIPLINARY APPROACH TO LIGHTING MUSEUM ARTIFACTS BY MEANS OF MODERN COGNITIVE TECHNOLOGIES
Authors: Kudliak V. M. , Bielan T. I. , Parkhomenko O. O. , Novohrudska R. L. , Savchenko Ya. V.
Published: November 2022

Nowadays, there is a rapid development of various web-resources that provide access to information of various kinds. Among such resources, it is possible to allocate a wide layer of cultural and historical sites and portals that display information about objects of the cultural heritage of world humanity in general, and our country in particular. Their demand has grown significantly in recent years. In the period of the pandemic and the regime of legal martial law, it is these resources that allow to display and familiarize with historical and cultural objects in an online format. Such resources include virtual museums, libraries, online archives, etc. In recent years, the function of organizing virtual throught museums and also objects of cultural heritage has gained considerable popularity. Using modern information technologies, user has the opportunity to independently build the routes of such tours, as well as view both a graphic representation of the object and its detailed description. Since historical and cultural values and heritage of civilization are presented with the help of such resources, they are not only enlightening, but also educational in nature. Their usage in educational process, as one of the main components of STEM education, allows comprehensive development of students' skills and competencies. The presented study describes a transdisciplinary approach to the modern educational and cultural sites development. Using the example of actually developed and operating web portal, innovative possibilities, methods and technologies for developing multidimensional structured information sites for presenting information about cultural heritage objects are described. The necessity and usefulness of latest cognitive technologies for improving the modern education process using cultural historical information resources is depicted.
MOTIVATIONAL SPHERE OF IMPROVEMENT OF PHYSICAL FITNESS OF STUDENTS OF ART EDUCATION IN GAME SPORTS
Authors: Lilchytskyi O. V. , Slobodianiuk T. B.
Published: November 2022

The study found that the activation of students’ health activities based on the use of sports and mastery of various sports skills is a motivating factor. Teachers of physical education, who conduct elective classes, are faced with the task of choosing ways and forms of organizing educational activities to master sports skills. The aim of the study was to reveal the essence of the implementation of the principles of health orientation and specify the components of readiness for physical activity (motivational, practical, psychophysiological and physical), clarify the criteria and identify indicators for high, medium and low levels. The study reveals the essence of the problem of forming a conscious positive attitude to physical education classes and a healthy lifestyle of students of art specialties in the conditions of optional groups. Regular physical activity is one of the key factors in maintaining health, and sufficient amount and regularity of physical activity – physical activity is a generating and stimulating factor in the process based on the natural connection of movements and the human psyche, which provides and controls the improvement of physical development and physical fitness of a person for life. The National Academy of Fine Arts and Architecture is a Ukrainian higher art educational institution that has an academic focus and trains specialists in painting, sculpture, graphics, theater and decorative arts, architecture, restoration of works of art, art history and art management. The sedentary lifestyle of art students is of concern to psychologists and educators. It is established that the introduction of health and development technologies contributed to the formation of a conscious attitude of students to their own health and sports: payload and motivation, caused a steady interest in a healthy lifestyle. The objectives of the optional classes are to promote the development of interconnected strong motor skills, abilities and the development of motor skills.
TRANSFORMATION OF THE EDUCATIONAL PROCESS IN THE CONVENIENCE OF THE COVID-19 PANDEMIC: CASE OF YAROSLAV MUDRYI NATIONAL LAW UNIVERSITY
Authors: Maryniv I. V. , Solyannik K. Ye. , Demura M. I.
Published: November 2022

During the study of the transformation of the educational process in the COVID-19 pandemic on the example of NSU we identified four main areas of such transformation: 1) transfer of the educational process from classroom classes to online classes using the Portal of educational electronic information systems. In this direction of research the results of data received from the Center of Information Technologies of the University were interpreted, the number of students’ appeals to the portal was compared, their own vision of the obtained results was given; 2) transformation of the work of the scientific library. In this regard, it was determined that the quarantine restrictions associated with the COVID-19 pandemic, the library quickly adapted to changes in the organization of scientific and educational processes at the University, provided a wide range of library and information services, educational activities online / offline. The total number of users on a single account, the number of applications from students for certificates, the number of “physical applications” to the scientific library during the implementation of distance learning were analyzed; 3) increasing the digital competencies of teachers to ensure a quality educational process has become the third area of research. It was found that the digital competencies of teachers in the challenges posed by the COVID-19 pandemic have become important due to the need to ensure a quality educational process and the impossibility of using conventional forms of teaching (teaching disciplines in classroom format, testing papers in paper form) etc). We conducted a survey of students of different courses and faculties on their assessment of digital competencies of teachers. The sample consisted of 509 respondents, representing three faculties: the Faculty of Prosecution, the Faculty of Justice, the Faculty of Advocacy. The results show that in general students rate the digital literacy of teachers above average; 4) increasing the digital competencies of students to acquire knowledge is defined by us as the fourth area of research. The obtained results testify to the importance of mastering digital competencies by teachers and students of the educational institution, the need for their continuous improvement, as well as the relevance of the issues under consideration.
Control strategies for reactive manipulation
Authors:   , Haviland Jesse
Published: November 2022

For a robot to operate in the real world, which is dynamic, unstructured, and unknowable, it must be able to react and adapt to the ever-changing state of the robot, environment, and goal. This thesis develops novel reactive motion controllers, which, unlike prior approaches, can rapidly, robustly and safely operate in real-world environments. The thesis also provides extensive software and educational materials to encourage the adoption and ongoing development of this new reactive robot motion paradigm.
Optical coherence tomography angiography assessment of retinal and choroidal vasculature: Diurnal and longitudinal changes and refractive error
Authors:   , Barsha
Published: November 2022

This research measured normal short-term, diurnal, changes, and longer-term changes across a year, in retinal and choroidal blood vessels, using optical coherence tomography angiography (OCT-A). It is the first research to show significant diurnal changes in retinal and choroidal OCT-A indices in healthy young adults, changes that differed between myopic and non-myopic patients. It also found that retinal OCT-A indices changes across a year in children but not adults. OCT-A measures of choroidal blood vessels were stable across the year in both adults and children. These findings benchmark normal OCT-A changes across time and have scientific and clinical value.
Ծնողական դեպրիվացիա ունեցող անձանց կենսա-իմաստային կողմնորոշումների և ինքնագնահատականի փոխհարաբերակցությունը/The Interrelationship of Meaning-Life Orientations and Self-Esteem among People with Parental Deprivation
Authors: Tarjumanyan Silvi
Published: November 2022

The article discusses the results of our research on correlations between meaning-life orientations and the level of self-esteem among people with parental deprivation. People who experienced parental deprivation as children are thought to have law self-esteem and a variety of issues with the existence of life objectives and judgments of meanings. We undertook studies to shed light on this problem. The goal of the study was to determine the connection between meaning of life and self-esteem among those who experienced parental deprivation. The problems of the study were to find out the expressiveness of meaning-life orientations and the level of self-esteem among research groups. The methodologies used in the study were D. Leontiev's “Meaning-life orientations” test and T. Dembo, S. Rubinstein “Self-esteem” test.
The primary conclusion from this study is that, despite that parental deprivation has been a source of difficulties, privation, dissatisfaction in the lives of people, who experienced it in childhood, in terms of the formation of the meaning of life and adequate self-esteem, the picture is almost the same in comparison with those without deprivation.
Հայկական ստարտափ էկոհամակարգի բաղադրիչային ազդեցությունները և զարգացման խնդիրները/The Effects of Components and Development Challenges of the Armenian Startup Ecosystem
Authors: Arshakyan Kristine
Published: November 2022

The purpose of this article is to study the current state of Armenian startup ecosystem according to each of the ecosystem components, to evaluate the degree of development of the ecosystem, as well as to reveal problems existing in the ecosystem that not only hinder its further development, but also prevent startup companies to have the necessary support from the ecosystem.
The objective of the work is to analyze the problems identified as a result of the study and to prepare recommendations based on it which will help to address some of the mentioned problems and to contribute to the further development of the Armenian startup ecosystem.
Տաղանդների կառավարման համակարգի առանձնահատ-կությունները ՀՀ առևտրային բանկերում/Features of the Talent Management System In Commercial Banks of the Republic of Armenia
Authors: Manukyan Lilit
Published: November 2022

Studies of the results of financial and economic activities of commercial banks and the interdependence of human resource management indicate that effective human resource management is one of the main factors ensuring the competitive advantage of banks. In this regard, banks have introduced new strategic approaches to human resource management, in particular, a talent management system.
This article aims to study and analyze the talent management systems implemented in commercial banks in the Republic of Armenia from the point of view of their applied effectiveness and the need for implementation. The tasks of the work are to identify the existing approaches to the management of human resources in RA commercial banks, the features and practical significance of the talent management system, to study and find out how the processes of talent recruitment, selection and personnel reserve formation, education and training contribute to increasing the competitiveness and efficiency of the banks.
Հատուկ տեղեկատվության ազատության ապահովումն ու պաշպանությունը ՀՀ-ում եվրոպական և միջազգային չափորոշիչների լույսի ներքո
Authors: Avetisyan Edgar
Published: November 2022

The research concerns the special freedom of information covering the basic right to receive information from public authorities. Within the framework of guaranteeing the mentioned right, certain non-determinations have been formed, which guide the provision of this right.
In the framework of the article, in the light of international and European legal approaches, the purpose of highlighting some problems arising around the provision and protection of the right to freedom of special information in RA is presented. To achieve this goal, first, the legal basis of this basic right is referred to, some theoretical interpretations about it, the international and European legal approaches are distinguished and their comparison with the legislative approaches in the RA case. The study was conducted using scientific methods of analysis and combination.
Էթնիկ լոբբինգը, որպես անդրազգային դերակատար. սփյուռքյան էլիտաների երկվության մարտահրավերը/Ethnic Lobbying as a Transnational Actor: the Challenge of the Duality of Diaspora Elites
Authors: Ghukasyan Gevorg
Published: November 2022

The purpose of this work is to reveal the transnational multi-layered political role of the diaspora, particularly the main actor of its political activity - the institution of ethnic lobbying, which implies dual relations between the homeland and the host state.
The article aims to understand the place and role of ethnic lobbying as a transnational political factor in modern international relations.
Historical-comparative, structural-operational and behavioral methods of scientific analysis were used to achieve the goal of the research and the solution of the set problems.
It was concluded that, the activity of ethnic lobby groups is aimed not only at supporting the homeland, but also at influencing. In addition, ethnic lobby groups can also be adversely affected by both the home state and the host state. In that context, however, lobby groups try to maintain their relatively independent role.
INTERVENSI MASALAH KECEMASAN PADA EKS WANITA TUNA SUSILA DI PANTI SOSIAL REHABILITASI TUNA SOSIAL CIREBON
Authors: Sanjaya Rama , Sari Qorir Yunia , Noor Nina Mariani
Published: November 2022

Wanita Tuna Susila (WTS) didefinisikan sebagai wanita-wanita yang memiliki kebiasaan melakukan hubungan seksual di luar ikatan perkawinan, baik diberi upah maupun tidak. Banyaknya WTS disebabkan adanya desakan kebutuhan ekonomi yang harus segera dipenuhi. WTS yang melakukan prostitusi sering mengalami kecemasan, karena adanya resiko memiliki penyakit menular, seperti penyakit kelamin dan kulit. Penelitian ini bertujuan untuk mengetahui permasalahan kecemasan yang dialami WTS dan upaya Pekerja Sosial dalam menanganinya serta meningkatkan keberfungsian sosialnya di Panti Sosial Rehabilitasi Tuna Sosial, Cirebon, Jawa Barat. Metode penelitian yang digunakan yaitu metode kualitatif deskriptif. Teknik pengumpulan data yang digunakan yaitu observasi, wawancara, dokumentasi serta kajian literatur lainnya sebagai pendukung penelitian ini. Hasil penelitian ini menunjukkan bahwa terdapat penurunan kecemasan yang dialami oleh eks WTS (klien), hal ini ditunjukkan dengan hasil dari skala HARS (Hamilton Anxiety Rating Scale) yang diberikan kepada klien yang sebelum dilakukan intervensi dengan skor 27 yaitu kecemasan sedang (15-27) dan setelah dilakukannya intervensi klien mendapatkan hasil 12 yaitu menurun menjadi kecemasan ringan (7-14). Selain itu, berdasarkan pengamatan peneliti yang diamati langsung, klien menunjukkan perubahan dari sebelumnya. Klien terlihat lebih bahagia, tenang dan menikmati aktifitas sehari-harinya. Klien mulai rajin beribadah melaksanakan sholat lima waktu, aktif mengikuti kegiatan dan membantu teman-temannya di panti.
Les sciences sociales et humaines en Afrique et la décolonisation des savoirs
Authors: Njuh Ludovic Boris Pountougnigni
Published: November 2022

Les sciences humaines et sociales sont un champ de savoir dont la particularité est de qualifier et de produire le sens dans la société. En Afrique, la pratique de la recherche et de la production du savoir dans ce domaine subiraient encore l’irradiation du savoir colonial dont les piliers étaient le logocentrisme, la domination et le centralisme épistémique autour de l’Europe. Ce travail questionne la construction de cet héritage, les rapports des Africains dans le sillage de la décolonisation et au lendemain des indépendances. L’enjeu est de cerner les nécessités et les voies de dynamisation de conceptualisation qui semble faire défaut. Il apparait que pour l’Afrique, la formulation du sens est une tâche indispensable de l’écriture de soi dans un monde où le jeu de perception dissimule souvent mal les projets hégémoniques qui allient pensée, image de soi et stratégie.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PENGISIAN PARTOGRAF SECARA LENGKAP OLEH BIDAN PRAKTEK MANDIRI DI WILAYAH KERJA PUSKESMAS LUBUK BEGALUNG PADANG TAHUN 2019
Authors: Febrianti Rini
Published: November 2022

Monitoring and recording of the condition of the mother and fetus in labor using partographs is an effort to reduce MMR and IMR. At present, partographs have not been implemented properly so that not all labor is monitored with partographs, as a result the abnormalities and complications that occur during labor are not detected early and clinical decision making cannot be performed. Based on reports from the DKK Padang in December 2018, it was still found that 25% of the incomplete partographs were filled out by independent midwives. From 2141 deliveries at the Lubuk Begalung Health Center. The study used analytic survey with cross sectional design. The study population was all independent practice midwives (BPM) who were in the work area of ​​the Lubuk Begalung puskesmas in the amount of 31 BPM and samples were taken with the total population. Data collection using a questionnaire with interviews on July 4 to August 5 2019. The results showed 45.2% incomplete partographs filling, have a low level of knowledge 25.8%, have a negative attitude 22.6%, and 83.9% no supervision. After being tested with Chi-Square found that there was a significant relationship between the level of knowledge, attitude, supervision with complete partograph filling (p <0.05). There is still a low level of supervision from the coordinating midwife in completing partographs in full by the Independent Practice Midwife. It is hoped that the coordinating midwife can increase supervision or supervision of the Mandiri practice midwife to complete the pertographs.
HUBUNGAN USIA DAN PARITAS IBU BERSALIN DENGAN KEJADIAN RETENSIO PLASENTADI RSUD RADEN MATTAHER PROVINSI JAMBI TAHUN 2018
Authors: Sulastri Sulastri
Published: November 2022

The high maternal mortality rate is a major problem that occurs in the health sector. The maternal mortality rate in Indonesia is still the highest in ASEAN. Childbirth is a highly anticipated thing for pregnant women. But in labor and after childbirth is a prone for mothers to experience bleeding that is so great. The main causes of maternal death in Indonesia were 67% bleeding (uterine atony by 22.88%, residual placenta at 19.40%, placental retention of 40.30%, and labor with birth canal laceration of 16.42%). Bleeding occurs 10 times more often during labor (Arifin, 2012).The purpose of this study was to determine the relationship of age and maternal parity with the incidence of placental retention in Raden Mattaher Regional General Hospital Jambi Province in 2019.The results showed that there was a relationship between age and incidence of retention of placenta in Raden Mattaher General Hospital in Jambi Province with a p value of 0.001 and there was no relationship between parity and the incidence of retention of placenta in RSUD Raden Mattaher Jambi Province, p value 0.102. It is expected that the results of this study are expected to be used as information material to prevent early occurrence of placental retention, because most of the incidence of placental retention can be predicted beforehand.
HUBUNGAN USIA DAN PARITAS DENGAN KEJADIAN INTRA UTERINFETAL DEATH DI RSUD RADEN MATTAHER PROVINSI JAMBI
Authors: Riya Rosa
Published: November 2022

According to the World Health Organization (WHO) and Obstetricians and gynecologists called Intra Uterine Fetal Death are fetuses that die in the womb with a body weight of 500 grams or more or the death of the fetus in the womb at pregnancy 20 weeks or more. IUFD is included in perinatal problems which is one of the health indicators, so this is very sensitive because it deals with maternal and perinatal health. IUFD is one of the causes of perinatal death (Saefudin, 2010). This study aims to determine the relationship between age and parity with Fetal Death Intra-Uterine Events in Raden Mattaher General Hospital Jambi in 2019. This study is an analytic case control study. Population of this study The population in this study was divided into two groups, namely the case group was the Fetal Death Intra-Uterine Incidence in 2018 as many as 44 people and the control group was not with the Intra Uterin Fetal Death Event in 2018. Samples were as many as 88 people were taken by total sampling technique.This research was conducted at Raden Mattaher Hospital in Jambi in May 2019. Data were analyzed by univariate and bivariate using the chi square test. The results showed that 57 respondents (64.8%) were at risk and as many as 53 respondents (60.2%) had no risk of parity. There is a relationship between age (p value = 0.002, OR = 4.929) and parity (p value = 0.191, OR = 1957) with Intra Uterine Fetal Death with p-value <0.05. There is a significant correlation between age and LBW incidence and there is no relationship between Parity and Intra-Uterine Fetal Death. The point that can be given in this study is that health workers improve services provided during pregnancy by providing counseling, counseling, and reminding mothers to detect early pregnancy complications and routine antenatal care.
HUBUNGAN RIWAYAT ABORTUS DENGAN RETENSIO PLASENTA PADA IBU BERSALIN
Authors: Wulandari Elza , Subani Pitri , Samsulsia Samsulsia
Published: November 2022

Retensio plasenta merupakan tertahannya atau belum lahirnya plasenta melebihi waktu 30 menit setelah bayi lahir yang dapat menyebabkan terjadinya perdarahan postpartum. Penelitian ini bertujuan untuk mempelajari hubungan riwayat abortus dengan retensio plasenta pada ibu bersalin di RSUD Dr Sobirin Kabupaten Musi Rawas Tahun 2017. Penelitian ini menggunakan pendekatan Survey Analitik dengan rancangan case control. Populasi penelitian ini adalah seluruh ibu bersalin di RSUD Dr. Sobirin Tahun 2017 sebanyak 1710. Sampel sebanyak 116 orang terdiri dari 58 orang retensio plasenta diambil secara total sampling dan  58 orang tidak retensio plasenta diambil secara systematic random sampling. Pengumpulan data dalam penelitian ini yaitu menggunakan data sekunder. Hasil penelitian: Ada hubungan yang signifikan antara riwayat abortus dengan retensio plasenta pada di RSUD Dr. Sobirin Kabupaten Musi Rawas, dengan kategori hubungan sedang.
The effects of Amlodipine and Propranolol on Haemodialysis Efficiency in End-Stage Renal Failure patients
Authors: Mohd Alaraj
Published: November 2022

Background: The high rate of death and sickness perceived in patients with end-stage renal disease is principally ascribed to the inadequacy of haemodialysis (HD), and this may relate to inadequate analysis of the factors affecting the HD process, including drugs taken by these patients. Aims and Objective: To explore the potential association of a dihydropyridine calcium channel blocker (amlodipine) and a beta-blocker prototype (propranolol) separately with the dialysis efficiency in HD patients. Methods: This is a retrospective study which include 275 (112 females and 163 males, 83% of whom also suffered from hypertension) patients with end-stage renal failure on haemodialysis. Patients were categorized into three groups: 125 patients taking amlodipine, 81 patients taking propranolol, and 69 patients not taking any of the above medications (controls). The HD efficiency, and the percentage reduction in creatinine, uric acid, and urea levels were compared between groups. Results: Compared with patients who were not receiving amlodipine or propranolol, a significant increase in the major HD adequacy marker which is the Kt/V ratio, as well as in the percentage reduction in creatinine, uric acid, and urea levels, was observed in patients taking amlodipine, but a significant decrease in these markers was detected in patients taking propranolol. Conclusions: Taken together, these findings indicate that the haemodialysis efficiency may be significantly improved (diminished) by supplementation with amlodipine (propranolol).
Standardization and In vitro Antioxidant activity of Schleichera oleosa (Lour.) Oken bark (Koshamra) – An Ayurvedic plant
Authors: S Latha , S Sathish
Published: November 2022

Scheleichera oleosa (lour) oken known as Khosamra in Ayurveda (Tamil-puvam, puvathi) is used to treat pain and rheumatism in different parts of India. However, scientific evidence to justify the traditional claims are lacking. Considering the traditional use of S.oleosa and the lack of information about its pharmacological properties, the present study was undertaken to standardize the bark material and to screen for its antioxidant potential. The physico-chemical evaluation, phytochemical analysis besides estimation of phenols and tannins were carried out. The antioxidant activity was evaluated through DPPH, nitric oxide radical scavenging and total antioxidant studies. Physico-chemical constants of the powdered bark material were determined. The phytochemical analysis revealed the presence of steroids, flavanoids, glycosides, carbohydrates, tannins, saponins, phenols and proteins. The phenol and tannin content were found to be high in methanol extract (42mg GAE/gm and 21mg TAE/g) respectively. Methanolic extract showed maximum activity against DPPH and nitric oxide radicals besides exhibited total antioxidant activity as 50.82µg Vitamin E equivalent/mg of extract. The bark of Schleichera oleosa was standardized using physico-chemical and phytochemical analysis. This provides information regarding the presence of phytoconstituents, also act as a standardization tool for its future identification. The results of antioxidant activity concluded that the bark of Schleichera oleosa is a potential source of natural antioxidant.
Synthesis of Sparfloxacin derivatives as an antibacterial, antimycobacterial agents with cytotoxicity investigation
Authors: Gurunani Gulshan , Agrawal Kapil , Walde Sheelpriya , Ittadwar Abhay
Published: November 2022

Based on earlier pieces of evidence of N-piperazinyl fluoroquinolone, and in search of new bioactive molecules from the fluoroquinolone class, the derivates of N-substituted piperazinyl quinolones were synthesized. A series of 2-((amino-1,3,4-thiadiazol-2yl)thio)-1-(4-subst.) (3a–j) were used for diazotization of amines in concentrated hydrochloric acid in the presence of Cu-powder, resulting into 2-((5-chloro-1, 3, 4-thiadiazol-2yl)thio)-1-(4-subst.)ethanone (4a-j). The reaction of (4a-j) with piperazinyl quinolone in dimethylformamide resulted (5a-j). The structure of synthesized compounds was confirmed by their spectral analysis. The compounds are screened against Staphylococcus aureus, Bacillus subtilis(Gram positive)and Escherichia coli, Pseudomonas aeruginosa,(Gram negative) and mycobacterium tuberculosis. The findings revealed moderate activity against Gram-positiveand poorly active against Gram-negative bacteria. Results indicated that halogenated analogs with nitro substitution (5b, 5e, and 5j) derivatives revealed antibacterial and antimycobacterial activity. The results advocate the need for further exploration of such derivatives, coupled with their preclinical and clinical investigation.
Formulation and Evaluation of Griseofulvin Solid Dispersion incorporated gel for topical application
Authors: Shukla Sonam , Upadhyay Swarnakshi , Kumar Gupta Rajneesh
Published: November 2022

In the present investigation, griseofulvin loaded solid dispersion were formulated using mannitol and PVP K30 as the hydrophilic carriers. The best formulation was then loaded in to gel formulation prepared either from carbopol 934P or HPMC. Melting method was adopted to prepare the solid dispersions of griseofulvin. The drug content was found to be highest in the formulation SD6 (94.60±0.7%) and the lowest in formulation SD1 (91.56 ±0.251%). A minimum of 10 fold increase in solubility was witnessed after formulating griseofulvin as SD. The minimum solubility was exhibited by SD1 (0.57±0.04mg/mL) whereas SD6 exhibited the highest solubility (2.09±0.080 mg/mL). SD6 released 47.16±1.167% after 15 min and around 80% drug released at 30 min. Hence SD6 was used for further formulation as gel. The pH value of all gel formulations lies within the 5.29 to 6.81 and they were homogeneous and uniform. The viscosity of the formulations ranged from 491±31 cp to 668±57.5 cp. The maximum amount of drug was released from formulation SDG2 (72.37%) followed by SDG4 (64.91%) by the end of 6th hour of the study. The formulation containing 1.0% of carbopol 934 was the gelling agent was considered to be the best formulation of all the prepared gels.
Design, Synthesis and Anticancer potential evaluation of Novel Naphthoic Acid linked Imidazo[2,1-b][1,3,4]thiadiazoles
Authors: Singh Satvir , D. Bhandari Divya. , Gupta Monika , Singh Jagdeep
Published: November 2022

A total of 18 derivatives S(1-18) of naphthoic acid linked Imidazo[2,1-b][1,3,4]thiadiazole were synthesized and tested for their anticancer potential at human cancer cell line A – 549. The interaction of the proposed derivatives with the colchicine binding domains of the receptor was also performed using Maestro 10.5 program (Schrodinger Inc. USA). Molecular docking study was performed for synthesized compounds displaying a significant inhibitory activity in order to validate their binding mode to active site. All the 18 inhibitors were docked into the active site of the receptor in two poses. The G-scores and binding energy for compound S4, S10, S12, S13 and S16 were observed to be comparable to the standard Colchicine. The compound S1, S5, S10, S12 and S16 exhibited prominent inhibition of cancer cell line.
Role of Zinc (II) Bio metal in complexation of Aspirin as Anti Stroke Drug
Authors: Chouhan Priyanka , Mishra Jyotsna
Published: November 2022

Stroke is becoming one of the biggest health hazardous now days. According to the data, it is estimated that it is becoming a third leading cause of death throughout the world. Aspirin, acetil salicylic acid is well known analgesic, anti-inflammatory and antipyretic drug. It also is having anticancer, anti-oxidant and anticonvulsant property. It plays a significant role in reduction of blood clotting as well as anti-stroke drug. But Aspirin has a property to cause ulcer and Zn bio metal is known to possess anti-ulcer as well as anti-inflammatory property. Keeping the importance of Zn(II) bio metal in mind and Zn(II) - Aspirin complex is prepared, its physicochemical and microbial studies have been carried out in solid and aqueous phases. On the basis of polarographic studies amperometric titrations and IR spectral studies the probable formula for the complex has been worked out to be 1:2. The metal ligand interaction has been studied using polarographic method at 27ºC and ionic strength µ = 1.0. A tentative structure has been suggested to the complex. A microbial study on the complex was carried out against various pathogenic bacteria and fungi. The results of studies revealed that the complex is more effective anti-stroke drug as compared to pure Aspirin.
Political Discussion on Television in Times of Elections: A Promise of Pluralism Social Media Users Hardly Recognize
Authors: López-Escarcena Ignacio , Ortega-Gunckel Constanza , Gronemeyer María Elena
Published: November 2022

In this research, we set out to analyze, on the one hand, the promises of pluralism of four television channels in the months before the referendum of October 25th, 2020, in Chile, and on the other hand, how YouTube and Twitter audiences reacted to them. Through a mixed method of content analysis and qualitative analysis, we found that pluralism was not one of the most mentioned aspects by the public in these social media. When there were allusions to it, the assessment was negative. This article seeks to contribute to studies on pluralism not only in Chile but also at a more general level, focusing on a global phenomenon, such as the possibilities of participation that social media provide to audiences who consume journalistic content.
The brunt of climate change on primary health care in Africa: Case study of a HASUWEB framework in Cameroon
Authors: Frankline Sevidzem Wirsiy  , Jean-Claude Kindzeka Wirsiy
Published: November 2022

The evidence from literature demonstrates how vulnerable people are to the major and impending threat of climate change (CC). Due to weaker health systems, populations in African nations are more susceptible to harmful consequences, and the balance of effects on health is unfavorable, necessitating more attention and efficient solutions. It is crucial to evaluate the potential health risks brought on by climate variations, such as heat stress, air pollution, waterborne disease, and vector-borne disease. In the past few years, there have been increasing publications about the CC issue in Cameroon. However, few publications emphasize the impact on health; specifically, primary health care (PHC). The quest for global health security can only be accomplished against the scenery of a united mainstreaming of CC response into the public health apparatus, especially in Africa and Cameroon in particular. This is in addition to acknowledging the myriad ways in which CC has an impact on PHC during COVID-19 pandemic and the recent monkeypox multi-country outbreak. In this paper, we highlight this global public health gap and elaborate on its implications using the HASUWEB framework (H: Harsh weather, A: Air pollution, S: Shifts in Vector Ecology, U: Upsurge of Allergens, W: Water and Food; Quality and Supply Impacts, E: Environmental Degradation, B: Bitter end Heat). We also provide recommendations for policy-makers to ensure an effective PHC-CC crisis nexus now and in the future.
Knowledge of sickle cell patients and attitudes and practices relating to the ophthalmological monitoring at the University Hospital of Bouaké (Côte d’Ivoire)
Authors: Yves Ouattara  , Zana Diabaté  , Thierry Yves Constant Sowagnon  , Liliane Ella Godé  , Mani Eric Omer Armand Digbé
Published: November 2022

Introduction: Sickle cell disease is a potentially blinding haemoglobinopathy. The aim of this study was to assess the impact of the knowledge, attitudes and practices of sickle cell patients relating to the disease and its ocular complications on their adherence to ophthalmological monitoring of sickle cell disease. Material and methods: Cross-sectional study by systematic recruitment of sickle cell patients received for any reason, in the outpatient department of the Bouaké University Hospital, during the study period. Results: Out of 50 sickle cell patients aged from 8 to 71 years (average of 28.12) the male accounted for 52%. Pupils and students were predominant (60%) and the patients from urban areas represented 92% (n=46). The patients with a high level and secondary level of education represented respectively 42.00% (n=21) and 40.00%. The AS forms and the SC forms were the most represented with respectively 34% (n=17) and 42% (n=21). Those who did not know if sickle cell disease could cause ocular damages represented 52.00% (n=26) and among the 21 (42%) who said they knew, those who did not know that the disease could be blinding by its ocular involvement were 15 accounting for (71.43%). The sickle cell sufferers who had never consulted an ophthalmologist as part of the follow-up of the disease represented 74.00% (n=37) and among them, 33 (89.19%) affirmed that the monitoring consultation had never been prescribed to them. Conclusion: Poor health education of the sickle cell patients is an obstacle to their adherence to the ophthalmological monitoring and the prevention of blindness due to sickle cell disease.
Effectiveness of minimally invasive glaucoma surgery (review of international experience)
Authors: Movsisyan A. B. , Egorov A. E. , Kuroyedov A. V.
Published: November 2022

The trends of recent years regarding the surgical treatment of the visual organ and its appendages are to minimize tissue traumatization during surgical manipulations, reduce their duration, as well as achieve the best possible outcome from the points of view of the doctor and the patient at minimal economic costs. Currently, the leading vector in glaucoma treatment remains the achievement of the target level of intraocular pressure (IOP). Taking into account the projected increase in the number of patients with glaucoma, conducting justified surgical treatment will remain relevant in the future. Its present state prompts the creation of new drugs, new means of their delivery, and surgical techniques with improved safety profile while achieving effective IOP reduction. In this regard, the trends in the development of surgical treatment of glaucoma have shifted towards procedures with minimal trauma to the eye tissues — minimally invasive glaucoma surgery (MIGS). The article discusses modern varieties of MIGS, theoretical and practical aspects of their application (effectiveness and safety profile), as well as prospects of their use.
VOICE CHAT WEB APP USING WEBRTC
Authors: Tiwari Avdhesh , Gupta Harshit , Mittal Sangam , Rawat Mayank
Published: November 2022

Technology improvements have made it possible to communicate more effectively. New technologies have improved existing communication routes. Some real-time communication systems include limitations, such as the need for additional software plugins and downloads to enable real-time communication, as well as security problems. Web Real-time Communication (WebRTC) is a technology that may be able to assist in the resolution of these issues. Thanks to advancements in internet technology, people may now easily access the internet. With the help of technological improvements, the internet is providing an increasing variety of services, all of which can be virtualized. People's internet communication has become ingrained in their daily lives. People used to communicate with one another by exchanging voice chat messages via the internet.In order to achieve scalability, the platform also makes use of cloud computing. The iterative platform architectural design is revealed, as well as some preliminary scalability analysis results.
Self-control, moral disengagement, and bullying behaviors in adolescents
Authors: Nisa Aziz Ul , Ahmed Jawaad , Arif Maham , Kazmi Syed Messum Ali , Mohsin Muhammad
Published: November 2022

This research work aimed to determine the correlation between self-control, moral disengagement, and adolescent bullying behavior. Data was collected from the Government and private colleges of Gujranwala, Punjab, Pakistan. The sample consisted of 200 boys and girls student. Co-relational research design and convenient sampling were used to collect data from students using tools, i.e., demographic information form, brief self-control scale, moral disengagement bullying scale, and Illinois bullying scale. The verdict indicated that self-control has significantly negative correlated with bullying behavior, and moral disengagement has significantly positive correlated with bullying behavior. The findings also showed that self-control does not correlate with moral disengagement. Furthermore, this study also examines many other factors that have significantly co-related with bullying behavior in adolescents, like gender, parental education, living status, educational center, educational level, drug abuse, relation with friends, and home environment. This research guides future researchers in developing culturally related intervention plans and policies for preventing adolescent bullying behavior.
Impact of smoking on oral health
Authors: Ullah Majeed , Siddiq Shahwar , Ur Rehman Atif , Quratulain Quratulain , Royaidar Jawad , Younus Rabia , Ali Qamreen
Published: November 2022

Introduction: Smoking kills more than 8 million people each year worldwide. The rate of morbidity from illnesses linked to smoking is increasing steadily. The adverse effects of smoking on oral health are well documented. The ability of medical and dental students to assist people in quitting smoking is crucial. Objectives: The aim of this study was to evaluate smoking habits, the level of knowledge and attitudes of medical and dental students towards smoking, as well as the role of dental professionals in prevention of smoking. Methodology: A cross-sectional study, including 150 medical and dental students from the Khyber Medical University, housing officers and dentists from the Hayatabad Medical Complex and Peshawar Dental College, was conducted and data was collected by a pre-designed questionnaire. The questionnaire asked about the patient's smoking and quitting habits, their medical and dentists' experiences with smoking cessation and their readiness to follow dentists' recommendations for quitting. Results: Most of the participants were medical students (81/150) and males (99/150). Majority of them were from 18-30 years old.
Orientación familiar: definiciones, propósitos, estrategias y procesos par garantizar el desarrollo multidimensional del ser humano
Authors: Morales Jesús
Published: November 2022

La orientación familiar como proceso sistémico, holístico y de transformación multidimensional, se erige en medio de una sociedad sumida en el conflicto, la incertidumbre y la complejidad, como alternativa estratégica para intervenir y prevenir problemas que obstaculizan el desarrollo humano integral y el bienestar de la familia. Por ende, se asume la necesidad de asesorar a la familia en el proceso de descubrir y asumir su posición como exigencias para enfrentar con seguridad y autonomía las dificultades emergentes de la cotidianidad.

Esto sugiere integrar la comunicación y el diálogo simétrico, la definición de reglas de comportamiento; sentido de corresponsabilidad, compromiso y disciplina para enfrentar los desafíos que impone la convivencia sana, respetuosa y equilibrada. En atención a estos requerimientos, el presente artículo responde a una revisión documental que propone una definición integral de la orientación familiar, delimitando sus propósitos y las posibles estrategias para generar relaciones de ayuda y acompañamiento, que potencien la calidad de vida y el desarrollo afectivo, social y emocional del individuo.

Se concluye que, la construcción de relaciones familiares satisfactorias requiere la prevención e intervención estratégica, procesos aportados por la orientación que procuran: construir vínculos sociales, afectivos y emocionales sólidos, que posibiliten la autonomía personal, el desarrollo de relaciones fundadas en el respeto y el reconocimiento; así como el manejo de la responsabilidad para gestionar los desafíos que se derivan de la convivencia cotidiana.
Los desafíos tecnológicos de los docentes de pregrado de la Universidad Católica de El Salvador en tiempos de pandemia
Authors: Morán de Menjívar Sofía Elizabeth , Aquino Guzmán Elsa Margarita , Estrada de Zaldívar Eva Luisa
Published: November 2022

El uso de la tecnología para el desarrollo de las asignaturas puede representar un desafío para los docentes; y en tiempos de pandemia, esta situación se acrecienta más. Este estudio descriptivo tuvo como finalidad determinar las bases educativas tecnológicas que tienen los docentes de la Facultad de Ciencias y Humanidades de la Universidad Católica de El Salvador para el desarrollo de sus asignaturas en modalidad virtual; además de describir las herramientas tecnológicas más utilizadas e identificar las dificultades más comunes en el uso de la tecnología. Para recopilar la información se aplicaron las técnicas de la entrevista y la observación.

Se encontró que el nivel de aplicación de tecnología, por parte de los docentes, oscila entre el intermedio y el avanzado. En cuanto al uso de herramientas y recursos, la mayoría los utiliza de forma óptima en las aulas virtuales de Moodle. Por otra parte, las dificultades que se experimentaron fueron los problemas de conectividad, debido a las zonas de residencia tanto de los estudiantes como de los docentes; y los problemas técnicos que suelen presentarse en el desarrollo de las clases.

Se pudo verificar que, tras la implementación de tecnología educativa en la transición de enseñanza presencial a virtual, es conveniente que los docentes de pregrado conozcan y apliquen las tecnologías de la información y la comunicación, ya que estas favorecen el autoaprendizaje y la elaboración de productos con componentes visuales que fomentan la creatividad didáctica del docente en beneficio del aprendizaje de los estudiantes.
Modelling of an interacting series process for rector cooling system using system identification method
Authors: Nur Aina Mohammad Abdul Aziz  , Azura Che Soh  , Ribhan Zafira Abdul Rahman  , Julia Abdul Karim
Published: November 2022

This research presents the modelling of cooling system plant in the TRIGA PUSPATI reactor (RTP). The RTP cooling system involves the interacting series process which are reactor model and heat exchanger model. The behaviour process is complex due to the nonlinearity, uncertainty, and time variation of the system. Due to the nonlinearity and interacting series process of system, the numerical algorithm for subspace state space system identification (N4SID) was proposed in the modelling of RTP cooling system. However, the model was converted to the transfer function form. The output response from the simulation model of RTP cooling subsystems were analysed by comparing the model with the real operational data. The responses of the model were within the respective range of a good model data. The residual analysis for each output was also calculated. The comparison and residual analysis were done to validate the model accuracy to determine the behaviour of the model. Overall, the model accuracy assessment shows that all models are still fit in the good model region (<10%) and has a good representation of a real plant.