bluuebunny/crossref_metadata_2025 huggingface dataset:
Social representations of tuberculosis by people with the disease
Authors: Moura Adriana Alaíde Alves , Silva Silvio Eder Dias da , Oliveira Márcia Aparecida Ferreira de , Rodrigues Diego Pereira , Rodrigues Diana Madeira , Rodrigues Héwelly Demétrio Itaparica , Ferreira Jaqueline Alves
Published: March 2024

ABSTRACT Objective: To understand the social representations of people with tuberculosis about the disease and its implications for following treatment. Method: A descriptive, qualitative study based on the Theory of Social Representations. It was conducted in a municipal health unit in the city of Belém. The participants were people diagnosed with tuberculosis and undergoing directly observed treatment, with the sample size defined by the data saturation technique. Data collection was done through semi-structured interviews. For data analysis it was used thematic content analysis. Results: The records converged into three categories: Representations of tuberculosis and its impacts on the diagnosis; The faces of treatment: challenges facing follow-up and hope; and Constructions of living with the disease in family and society. Final considerations: Living with the disease transforms everyday life and relationships. Discrimination and prejudice denote the need to reconfigure such representations for patients to be embraced.
Barreiras que afetam a sustentabilidade financeira de sistemas de gerenciamento integrado de resíduos sólidos urbanos
Authors: Brumatti Dayane Valentina , Chaves Gisele de Lorena Diniz , Siman Renato Ribeiro
Published: March 2024

Resumo O gerenciamento integrado d resíduos sólidos urbanos (GIRSU) é considerado um desafio pelos municípios por diversos fatores, sendo o principal a alta demanda financeira do processo. A ineficiência na prestação desse serviço está associada à falta de entendimento sobre os diversos elementos que afetam todo o sistema de gerenciamento, dificultando a tomada de decisão pelos gestores. Desta forma, este artigo tem como objetivo identificar as barreiras que afetam a sustentabilidade financeira do GIRSU. A pesquisa bibliográfica selecionou 48 artigos nas bases Scopus e Web of Science, empregando o método Smart bibliometrics para subsidiar a análise sistemática. Os elementos foram apresentados e discutidos o potencial de influência sobre o sistema de gerenciamento de resíduos, em quais países decorrentes do nível de desenvolvimento tiveram mais trabalhos publicados na área e uma discussão sobre cada elemento apontado. Os resultados identificaram lacunas de pesquisa como a ausência de uma análise em que considere a inter-relação entre os elementos levantados, e ausência de estudos acerca dos métodos que podem ser utilizados para isso. Esse estudo fornece importantes contribuições a fim de planejar, alterar ou implementar sistemas de GIRSU nos municípios cidades, fornecendo informações sobre os elementos críticos que afetam a sustentabilidade financeira do gerenciamento dos RSU.
Padrões de tomografia computadorizada da COVID-19 em pacientes em terapia renal substitutiva
Authors: Carmo Gabriel Assis Lopes do , Oliveira Mariana Paiva , Campos Anna Luiza Lino , Couto Bráulio Roberto Gonçalves Marinho , Carmo Lilian Pires de Freitas do , Cerqueira Tiago Lemos , Souza Camila Alencar Monteiro de , Goll Yan Lopes , Souza Vitor Santos de , Vieira Mariana Oliveira Guimarães , Castro Pedro Alves Soares Vaz de , Lemos Pedro Augusto Botelho , Silva Ana Cristina Simões e
Published: March 2024

RESUMO Introdução: Doenças pulmonares são comuns em pacientes com doença renal em estágio terminal (DRET), dificultando o diagnóstico diferencial com COVID-19. Este estudo descreve achados de tomografia computadorizada de tórax (TC) em pacientes com DRET em terapia renal substitutiva (TRS) hospitalizados com suspeita de COVID-19. Métodos: Indivíduos maiores de 18 anos com DRET, encaminhados ao pronto-socorro com suspeita de COVID-19 foram incluídos. Dados clínicos e epidemiológicos foram extraídos de registros eletrônicos de saúde. A TC foi classificada como típica, indeterminada, atípica, negativa. Comparamos achados tomográficos de pacientes com COVID-19 positivos e negativos. Resultados: Recrutamos 109 pacientes (62,3% COVID-19-positivos) entre março e dezembro de 2020, idade média de 60 ± 12,5 anos, 43% mulheres. A etiologia mais comum da DRET foi diabetes. Tempo médio em diálise foi 36 meses, intervalo interquartil = 12–84. A lesão pulmonar mais comum foi opacidades em vidro fosco. O padrão típico de TC foi mais comum em pacientes com COVID-19 (40 (61%) vs. 0 (0%) em pacientes sem COVID-19, p < 0,001). Sensibilidade 60,61% (40/66), especificidade 100% (40/40). Valores preditivos positivos e negativos foram 100% e 62,3%, respectivamente. Padrão atípico de TC foi mais frequente em pacientes COVID-19-negativos (9 (14%) vs. 24 (56%) em COVID-19-positivos, p < 0,001), enquanto padrão indeterminado foi semelhante em ambos os grupos (13 (20%) vs. 6 (14%), p = 0,606), e padrão negativo foi mais comum em pacientes COVID-19-negativos (4 (6%) vs. 12 (28%), p = 0,002). Conclusões: Em pacientes com DRET em TRS hospitalizados, um padrão atípico de TC de tórax não pode excluir adequadamente o diagnóstico de COVID-19.
A conjuração dos Kiriris: sublevação indígena e disputa de terras no sertão da Bahia no final do século XVIII (1797-1798)
Authors: Santos Fabrício
Published: March 2024

Resumo Este trabalho explora o testemunho inédito de uma conspiração indígena ocorrida no sertão da Bahia em 1797. Metodologicamente, o artigo está baseado na análise da única fonte disponível sobre o episódio: a devassa realizada pelo juiz ordinário da vila do Itapicuru de Cima por ordem do governador da Bahia. A região sertaneja baiana foi marcada pela disputa de terras entre habitantes indígenas e europeus ao longo de todo o período colonial. Os Kiriris – que integravam a maior população indígena do sertão baiano – foram derrotados pelos colonizadores no final do século XVII, sendo aldeados e administrados pelos jesuítas até 1758, quando suas aldeias foram transformadas em vilas. A revolta de 1797 ocorreu quando um líder indígena chamado José Félix Cabral tentou assumir o comando da tropa de ordenanças a fim de expulsar os portugueses das terras da vila de Pombal, antiga aldeia de Canabrava. Cabral foi preso, mas seu sobrinho Victoriano Francisco continuou o protesto, tentando reunir indígenas de outras povoações da região. Não sabemos o que aconteceu a seguir, mas a análise da documentação revela a agência e o protagonismo indígena em um momento fundamental da história brasileira.
Inovação educacional em três periódicos brasileiros de História da Educação (1997-2022)
Authors: Gatti Júnior Décio
Published: March 2024

Resumo Trata-se da comunicação de resultados de investigação sobre a presença da temática da inovação educacional em três periódicos brasileiros da área de História da Educação publicados entre 1997 e 2022, a saber: Revista História da Educação, criada pela Asphe, em 1997; Revista Brasileira de História da Educação, criada pela SBHE, em 2001; Cadernos de História da Educação, criada pelo Nephe/UFU, em 2002. A busca partiu dos termos Escola Nova, Renovação e Inovação. As informações coletadas foram classificadas nas seguintes categorias: ano de publicação; autorias, vínculos institucionais e países; títulos, temáticas, países e períodos abordados. Os resultados demonstraram que a produção na temática da inovação educacional foi contínua e significativa, com a publicação de 149 artigos pelos três periódicos, nos quais houve predominância de autorias, instituições e objetos de estudo relacionados ao espaço luso-brasileiro, com privilegiamento temporal da década de 1930.
How should hyperbilirubinemia be considered in the definition of the hearing screening protocol for neonates at risk?
Authors: Alvarenga Kátia de Freitas , Campelo Anna Paula Dionizio da Silva , Rays Marina Saes , Amorim Alice Andrade Lopes , Araújo Eliene Silva , Jacob Lilian Cassia Bornia
Published: March 2024

ABSTRACT Purpose To analyze hyperbilirubinemia as an indicator for the definition of risk protocol in newborn hearing screening (NHS) and in auditory monitoring in full-term and preterm neonates. Methods This is an observational, cross-sectional and retrospective study. A total of 554 children born in a public maternity hospital were included and divided into two groups: (G1) with 373 full-terms neonates; (G2) with 181 preterm neonates. Data were collected from the participant’s medical records to obtain information regarding the result of the NHS, performed by recording the automated auditory brainstem response (AABR), birth conditions, clinical characteristics, interventions performed, and results of the first test of total bilirubin (TB) and indirect bilirubin (IB) as well as the peak of TB and IB. A descriptive statistical analysis of the results was performed, and the level of significance adopted was 5%. Results On the NHS test, quotes of retest referral rates were smaller in G1 when compared to G2. There was no significant difference between the groups regarding type of delivery, gender, presence of Rh and ABO incompatibility, G6PD enzyme deficiency, and performance of phototherapy. TB and IB levels at the first exam and at peak time did not differ between neonates with “pass” and “fail” results on the NHS test in both groups. Conclusion Bilirubin levels in the neonatal period below the recommended values for indication of exchange transfusion are not directly related to the “fail” result on the NHS tests in term and preterm neonates.
Uma pessoa trabalhadora e “família”: a identidade concurseira nas representações de Instagram
Authors: Maia Mário S. F. , Neris Lucas G. D.
Published: March 2024

Resumo Esta é uma pesquisa desenvolvida no âmbito da sociologia das profissões jurídicas com o objetivo de identificar o processo de construção da identidade concurseira a partir da análise das representações do eu no espaço de socialização virtual do Instagram. Realizou-se análise “dramatúrgica” inspirada nas pesquisas de Ervin Goffman das interações ocorridas nos perfis de Instagram de 44 atores em representação no mundo dos concursos durante o mês de junho de 2022. O trabalho interpretativo consistiu na busca pela identificação de valores compartilhados pelos integrantes do heterogêneo grupo de análise. Percebemos uma disposição de grupo constante para a representação de um tipo trabalhador e ordeiro, avesso ao conflito aberto e materializador dos “valores familiares”. Rotulamos esses traços de identidade como os de uma pessoa “trabalhadora” e “família”. Concluímos que (1) há uma grande diferença entre os valores “profissionais” das carreiras jurídicas e os valores “concurseiros” em circulação no espaço social e que (2) isso nos permite diagnosticar a existência de problemas significativos no contexto do exercício concreto das atividades institucionais de formação e controle da “moral oficial” dentro do campo jurídico profissional, nas escolas de formação, nas corregedorias e nos tribunais de ética.
Dez anos da Política Nacional de Saúde do Trabalhador e da Trabalhadora e os desafios da formação para (trans)formação do trabalho
Authors: Hennington Élida Azevedo , Santos Gideon Borges dos , Pasche Dário Frederico
Published: March 2024

Resumo O objetivo do artigo, de natureza teórica, é discutir a formação em saúde tomando como referência a Política Nacional de Saúde do Trabalhador e da Trabalhadora (PNSTT), que no ano de 2022 completou dez anos. Essa reflexão crítica está baseada em revisão de literatura e na experiência profissional dos autores em ensino, pesquisa e serviços no campo da Saúde Coletiva/Saúde do Trabalhador. A PNSTT preconiza a capacitação e o desenvolvimento da força de trabalho em saúde de nível médio e superior, com prioridade às equipes de Vigilância em Saúde e da Atenção Primária/Estratégia Saúde da Família. A formação em saúde deve considerar o trabalho em sua função ontogenética enredada no sistema capitalista que o transforma, paradoxalmente, em afirmação e negação do sujeito: pelo trabalho nos tornamos humanos e sob as regras do capital o trabalho se torna arriscado e adoecedor. A formação enseja a construção de modos de trabalho conjunto e diálogo permanente entre trabalhadores e demais atores sociais, desde o planejamento até a efetivação e posterior avaliação dos projetos formativos em saúde, trabalho e ambiente. Atuando de forma democrática, coletiva e organizada, é possível reinventar práticas concretas de educação e trabalho na perspectiva da formação cidadã.
Outbreaks and epidemics investigations: changes in theories, concepts, and practices from the 18th to the 21st century
Authors: Barata Rita Barradas
Published: March 2024

Abstract This essay aims to discuss the investigation of outbreaks and epidemics, from the first reports available in scientific literature from the 18th century to the present time, using scientific articles and books on the subject for its construction. The main argument developed is the transition from qualitative approaches of epidemiology, which predominated in the early periods, to the quantitative approach, which initially coexists with the qualitative one but became dominant from the second half of the 19th century. It concludes with a brief reflection on the current moment of confronting the COVID-19 epidemic.
La hegemonía del modelo biomédico desde las representaciones del personal de salud en el contexto de un modelo de atención en salud con enfoque intercultural en Chugchilán, Ecuador
Authors: Quiroz-Hidrovo Ana Lucía , Larrea-Killinger Cristina , Rodríguez-Martín Dolors
Published: March 2024

Resumen Este artículo pretende conocer cómo se pone en práctica el enfoque intercultural en el contexto del Modelo de Atención Integral de Salud con enfoque Familiar, Comunitario e Intercultural en Chugchilán (Ecuador), mediante los conocimientos, percepciones y prácticas que aplica el equipo de salud en la atención materno-infantil. Estudio etnográfico, en que participaron 21 profesionales sanitarios entre profesionales indígenas -técnicos de atención primaria de salud- y no indígenas del Centro de Salud. Las técnicas llevadas a cabo fueron observación participante y entrevistas en profundidad. Los datos generados se analizaron mediante análisis del contenido temático. El análisis de los datos evidenció que la hegemonía del modelo biomédico operante podría constituir una limitación en el desarrollo del enfoque intercultural, sin embargo, el personal de salud indígena, desde su rol ambiguo y contrario al modelo biomédico, emerge como un elemento contrahegemónico y articulador real entre los saberes biomédicos e indígenas en contextos interculturales de atención-autoatención.
As relações geométricas subjacentes nas cascas de Eladio Dieste
Authors: Melachos Felipe Corres , Florio Wilson
Published: March 2024

Resumo Apenas na última década, a obra do engenheiro Uruguaio Eladio Dieste (1917-2000) vem ganhando disseminação acadêmica internacional, sendo que uma de suas principais contribuições para a concepção formal-estrutural na arquitetura e engenharia civil foi o desenvolvimento iterativo da tipologia estrutural das abóbadas gaussianas, cascas de dupla-curvatura estruturadas em cerâmica armada. Entretanto, não há registros de uma definição estabelecida para a geometria arquitetônica destas tipologias estruturais. Tampouco existem evidências concretas acerca da concepção e desenvolvimento projetual destas estruturas. Por conseguinte, o objetivo deste artigo é evidenciar as relações geométricas subjacentes nas abóbadas guassianas descontínuas projetadas e construídas por Eladio Dieste em cerâmica armada, a variação dominante desta tipologia estrutural. Esta análise foi conduzida através da modelagem paramétrica e da regressão polinomial de estudos de caso selecionados a partir de fontes primárias originais, justamente por estas ferramentas computacionais permitirem o correto manejo de geometrias tidas como formalmente complexas. A contribuição esperada para esta pesquisa reside em aprofundar o entendimento entre a relação do processo de projeto e a geometria resultante no objeto de estudo, assim como o entendimento da conformação geométrica desta tipologia estrutural desenvolvida por Eladio Dieste.
Bacterial community dominance in a sewage-driven eutrophic coastal lagoon by next generation sequencing: initial findings
Authors: Leite Analy Machado de Oliveira , Molisani Mauricio Mussi , Oliveira Renan Monte de , Pontes Paula Veronesi Marinho , Fonseca Rodrigo Nunes da , Menezes Jackson de Souza , Gomes Neto Lupis Ribeiro , Esteves Francisco Assis
Published: March 2024

Abstract: This study investigates the presence of bacterial dominance in one of the most studied sewage-driven eutrophic coastal lagoons, the Imboassica Lagoon in Macaé (RJ), Brazil, utilizing high-throughput sequencing of 16S rDNA. Water samples were collected from three sites within the lagoon. Total microbial DNA was extracted, and the V3-V4 region of the 16S rRNA gene was amplified and sequenced on the Illumina MiSeq platform. A total of 744,879 partial 16S rRNA sequences were clustered, revealing the absence of a single bacterial dominance in the sewage-driven eutrophic coastal lagoon. The prominent phyla detected in the lagoon were Cyanobacteria (27.8%), Proteobacteria (23.7%), and Actinobacteria (14.6%). Proteobacteria emerged as the most abundant phylum in the sewage-impacted lagoon site, whereas Cyanobacteria dominated the other two sampling sites. Among families, Synechococcaceae predominated with genus Synechococcus exhibited the highest prevalence. Families of potentially toxic Cyanobacteria represented less than 1% of the total families. The sewage-impacted lagoon section displayed greater bacterial diversity and richness. The dominance of bacterial communities associated with raw sewage, such as members of the Enterobacteriaceae family, was not confirmed, constituting only 0.75% of the families in the most affected site. This study presents the initial analysis of the bacterial community in the Imboassica Lagoon and suggests that dominance in the lagoon responds to the eutrophication and sewage discharge.
ANALYSIS OF THE CHALLENGES IN DEVELOPING SAMPLE-BASED MULTIFIDELITY ESTIMATORS FOR NONDETERMINISTIC MODELS
Authors: Reuter Bryan W. , Geraci Gianluca , Wildey Timothy
Published: March 2024

Multifidelity (MF) uncertainty quantification (UQ) seeks to leverage and fuse information from a collection of models to achieve greater statistical accuracy with respect to a single-fidelity counterpart, while maintaining an efficient use of computational resources. Despite many recent advancements in MF UQ, several challenges remain and these often limit its practical impact in certain application areas. In this manuscript, we focus on the challenges introduced by nondeterministic models to sampling MF UQ estimators. Nondeterministic models produce different responses for the same inputs, which means their outputs are effectively noisy. MF UQ is complicated by this noise since many state-of-the-art approaches rely on statistics, e.g., the correlation among models, to optimally fuse information and allocate computational resources. We demonstrate how the statistics of the quantities of interest, which impact the design, effectiveness, and use of existing MF UQ techniques, change as functions of the noise. With this in hand, we extend the unifying approximate control variate framework to account for nondeterminism, providing for the first time a rigorous means of comparing the effect of nondeterminism on different multifidelity estimators and analyzing their performance with respect to one another. Numerical examples are presented throughout the manuscript to illustrate and discuss the consequences of the presented theoretical results.
Dr. Caligari’s Francis: A Sane Reading
Authors: Blanchard Alan
Published: March 2024

A novel reading of The Cabinet of Dr Caligari demonstrating the protagonist, Francis, is sane and seeking asylum in an asylum to avoid certain death in WWI. If Francis is sane, then Caligari is a powerful anti-authoritarian, anti-war film without caveat complementing its status as an international horror classic.
A History Of The World According To Getty Images
Authors: Misek Richard
Published: March 2024

A montage of some of the last century’s most iconic images forms the basis of an investigation into the power that commercial image archives hold over our shared cultural memory, and an attempt to reclaim a few fragments of their collections from corporate control.
Lizard Train
Authors: Ferguson Kevin L.
Published: March 2024

Lizard Train is a video made after Catherine Grant’s "Carnal Locomotive" (2015). Using a clip from A Lizard in a Woman’s Skin (Lucio Fulci, 1971) rather than Le Jour et l’heure (René Clément, 1963), the piece questions how videographic criticism is alternately a mechanical and an intuitive form of knowledge production.
Revisiting Bruxelles-Transit
Authors: Stratil Jasper
Published: March 2024

A reflection on Samy Szinglerbaum's Bruxelles-Transit to unravel different layers of history. The account of Szinglerbaums’s family history becomes intertwined with other histories: the history of the Diaspora, of the Shoah, of Brussels as a space of transit, and eventually of film history.
A Place in the Nation: Nationhood in Larraín's No (2013)
Authors: Ó Murchú Niall , Miller Mark , Wolk Sam
Published: March 2024

Pablo Larraín’s film No (2012) generated intense interest in Chile and abroad for its treatment of television advertising in Pinochet’s 1988 plebiscite defeat. The film is now central to “the memory wars” in Chile (Stern 2010). Debate has focused on the relationships between film narrative and history, and between the cheerful campaign and dismal present. My video essay instead examines the rival narratives of national peoplehood reconstructed in Larraín’s movie.
Don’t Look Now: Paradoxes of Suture
Authors: Denson Shane
Published: March 2024

This video essay, presented here in both interactive and linear forms, explores suture, space, and vision in Nicolas Roeg's Don't Look Now (1973), concentrating on one key scene in the film – an important turning point that problematizes both the characters' and the spectator's perspectives vis-à-vis narrative events.
Why So Serious? Clowning, the Method, and Performative Adaptations of the Joker
Authors: Taylor Aaron , Hewko Bryn , Evernden C. Blake , Harper-Brown Ryan
Published: March 2024

This video essay treats on five live-action, filmic representations of the Joker. These instantiations of the same adapted character provide analysts with an opportunity to catalogue expressive strategies of physical instantiation. By contrasting performance choices that showcase distinctive versions of the same character, the video demonstrates how actors creatively contribute to a film’s aesthetics.
Measuring Unemployment Risk
Authors: Chapuis Brendan J. , Coglianese John
Published: March 2024

In this note, we introduce a measure of unemployment risk, the likelihood of a worker becoming unemployed within the next twelve months. By using nonparametric machine learning applied to data on millions of workers in the US, we can estimate how unemployment risk varies across individuals and over time.
Sustainability of the hookah diving fishery in Turkey
Authors: Karadurmuş Uğur , Aydın Mehmet
Published: March 2024

Hookah diving is a traditional fishing method based on the hand collection of commercial benthic organisms. Fishers continue their profession without paying attention to their physical health and psychophysical fitness. Ignoring the diving safety and decompression rules underwater, using improvised diving systems, and economic concerns carry risks that can result in death. The long-term sustainability of work depends on nations’ ability to control fishing practices and promote good management. This study discusses the current situation of hookah divers in Turkey based on official statistics from the ministry and face-to-face interviews with hookah divers. The data were subjected to strengths, weaknesses, opportunities, and threats (SWOT) analysis and synthesised with the literature for strategic analysis. The sector’s contribution to the national economy, economic satisfaction of divers, and supporting rural employment were evaluated as strengths. Lack of expertise in the professional career and complex laws were identified as threats that require urgent solutions. Multidirectional national efforts are needed for sustainable fishing, including stakeholder networking, diving safety, hookah equipment, underwater fishing strategies, training curricula and professional career development. Our findings offer strategic and planning approaches for the sustainable development of hookah diving in Turkey.
Nonlinear Mathematical Analysis based on an Insulin-Pancreatic Cells Model in the Presence of Epinephrine
Authors:   Instituto Tecnológico de Tijuana, Gamboa Diana , Campos Paúl J. ,   Instituto Tecnológico de Tijuana
Published: March 2024

In this work, a nonlinear model is studied based on ordinary differential equations that describe the relationship between the mass of cells and the secretion of epinephrine. It analyzes the impact of stress associated with the cause of increased blood pressure and glucose levels in the body. The mathematical analysis is based on the appliance of the nonlinear control theory to define the maximum load capacity for each state variable, establishing a bounded positive invariant domain through the Localization of Compact Invariants Sets (LCIS) method. The objective is to determine the effects of epinephrine secretion on the increase of blood glucose levels; therefore, this analysis's results define the necessary and sufficient conditions in which epinephrine raises insulin and glucose levels in the presence of cells. The interest in studying this type of disease focuses on searching for a treatment or an analysis that guarantees complete control of glucose levels. This work's development and mathematical analysis strengthen current research on insulin-dependent diabetes mellitus around critical epinephrine factors that imply an increase in glucose in the body.
Macroalgae Analysis v1
Authors: Rodriguez Nohea
Published: March 2024

Determine the abundance and biomass of the invasive macroalgae species, Turbinaria and Sargassum. Then, identify marine species located on random samples of each species. Turbinaria decreases fish abundance and biodiversity, competing with native algae and coral for space and resources. Determine the effect on biodiversity if Turbinaria were to be removed from an ecosystem entirely. Under the guidance of Maya Lin, the ISP class will conduct transect data collection in Baie Vaiori, located in Mo'orea. The objective is to gather data on the spatial occupancy of algae. Additionally, algae will be gathered to bring back to the lab where they will be examined for any residing organisms.
LC-MS/MS analysis of 5 steroids in plasma in a clinical study of Congenital Adrenal Hyperplasia v2
Authors: Kyle Catriona , Just George , G Denham Scott , ZM Homer Natalie
Published: March 2024

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders that affects adrenal steroidogenesis, resulting in deficiency of the glucocorticoid cortisol and in many cases the mineralocorticoid aldosterone1. This resulting lack of glucocorticoid (and mineralocorticoid) activates the hypothalamic-pituitary-adrenal (HPA) axis causing excessive release of adrenocorticotrophic hormone (ACTH) and excess adrenal androgen synthesis. Diagnosing and treating CAH requires reliable methods for steroid analysis. Tandem mass spectrometry methods coupled with chromatographic separation are considered the gold standard analytical technique for steroid analysis2 with the added benefit of enabling simultaneous analysis of multiple steroids. There are a range of methods that have been developed to measure multiple steroids in CAH3. Here we have developed a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for application to a clinical study that specifically explores the administration of d8-corticosterone as an alternative to hydrocortisone for CAH treatment. Plasma samples (200 µL) were enriched with isotopically labelled steroids, diluted with water (0.1% formic acid v/v) and extracted alongside a (0.0025 - 400 ng) calibration curve, by automated 96-well supported liquid extraction (SLE), using dichloromethane and isopropanol as an organic solvent, on a Biotage Extrahera automated sample handler. Extracted steroids were separated on a Shimadzu Nexera uHPLC with gradient elution on a Kinetex C18 column (150 x 3 mm; 2.6 µm) and a mobile phase of methanol and water (0.1% formic acid in water and methanol). The run time was 16 minutes, followed by mass spectral analysis on an AB Sciex 6500+ tandem quadrupole mass spectrometer operated in multiple reaction mode, positive ionisation. The method measures five steroids - hydrocortisone (cortisol) and d8-corticosterone - combined with markers of CAH - androgens and the intermediate 17α-hydroxyprogesterone, alongside the internal standards - in plasma. Validation demonstrated that this method is sensitive, specific, and reliable.
Solid-State Electrolytes for High-Energy-Density Lithium-Ion Batteries: Challenges and Opportunities
Authors: Mallipeddi Suman Reddy , Goda Dileep Reddy
Published: March 2024

For various applications, solid-state electrolytes (SSEs) present exciting possibilities for improving lithium-ion batteries' performance, stability, and safety (LIBs). To shed light on the significant variables influencing the direction of energy storage technology in the future, this paper examines the opportunities and problems related to SSEs for high-energy-density LIBs. The study's primary goals are to explore the characteristics and difficulties of SSEs, appraise manufacturing methods, appraise the effectiveness of SSE-based LIBs, and investigate potential future directions and policy ramifications. The study's methodology involves a thorough literature analysis, summarizing previous research findings and highlighting areas and chances for additional investigation. Significant discoveries emphasize how crucial multifunctional SSEs, interface engineering, improved materials design, scalable manufacturing techniques, and international cooperation are to the advancement of SSE-based LIBs. Policy implications: To expedite the development and deployment of SSE-based energy storage systems, investments in infrastructure, regulatory standards, environmental sustainability, and cooperative research projects are essential.
Accessibility Evaluation of Interactive Learning Mobile Applications for Individuals with Intellectual Disabilities
Authors:   Department of Electrical Engineering and Informatics, Vocational College, Universitas Gadjah Mada, Yogyakarta, Indonesia, Hardiyanti Margareta
Published: March 2024

In today’s education sector, mobile technologies, including tablets and smartphones, have become integral tools, enabling the implementation of mobile learning in pedagogical activities. However, accessibility issues in mobile applications pose challenges, particularly for individuals with disabilities, contradicting the goals of Sustainable Development and the Convention on the Rights of Persons with Disabilities. This paper aims to investigate the extent to which the industry considers accessibility in designing mobile learning applications for this specific user group. We evaluate the accessibility of interactive mobile applications designed for reading and alphabet learning, employing two different guidelines, by conducting heuristic evaluation based on research-based guideline and a design standard introduced by The World Wide Web Consortium. Three experts, each bringing a unique perspective and background, were engaged in the evaluation process. The heuristic evaluations were executed based on the criteria outlined in the selected guidelines. This involved identifying violations and employing a scoring system to quantify the findings. Subsequently, the experts engaged in discussions to achieve consensus and establish final scores for each checkpoint. The results provided a quantitative basis for our analysis. The results of the evaluation performed in this study expose a prevalent disregard for guideline checkpoints among these interactive mobile learning apps. Only two applications could be considered highly inclusive, indicating the need of improvement. Based on the results, the accessibility criteria were also categorized into four primary groups, highlighting the requirements that were least and most addressed by the applications.
In Vitro Regeneration of Ragleaf (Crassocephalum crepidioides (Benth.) S.Moore) Using Kinetin
Authors: Murtadha Abdulsalam Mosobalaje , Oladejo Olanike Omobolanle
Published: March 2024

Micropropagation is a valuable means for large-scale production and preservation of invasive alien species such as ragleaf. To determine the concentration of kinetin adequate for in vitro growth of the ragleaf flower, seeds of the plant were propagated in vitro using Murashige and Skoog medium supplemented with basal 0.5 mg L-1 Naphthalene Acetic Acid and incubated for four weeks. The growing shoots were cut into pieces and inoculated into MS media with five kinetin concentrations: 0.0, 1.0, 1.5, 2.0, and 2.5 mg L-1. The tubes were kept in an incubation room for seven weeks. The experiment was arranged in a completely randomized design with ten replications. Shoot length (cm) and the number of leaves, nodes, and roots were measured. The control medium recorded less growth performance across all the variables, indicating the important role of the exogenous kinetin. The plants in 2.50 mg L-1 kinetin were the tallest (7.23±0.87 cm) with the highest number of leaves (28.17±2.57), nodes (10.50±1.02) and shoots (3.83±0.17). The media containing 2.50 mg L-1 kinetin also produced the highest number of roots (9.00), which is necessary for the survival of the seedlings. The results indicate that 2.5 mg L-1 is adequate for cultured C. crepidioides.
Profesor Jakub Karol Parnas: 140 rocznica urodzin
Authors: Barańska Jolanta , Dżugaj Andrzej , Szewczyk Adam
Published: March 2024

In 2024, it will be 140 years since the birth of Jan Karol Parnas, one of the most outstanding biochemists and one of the most outstanding Polish scientists of the first half of the 20th century. The article presents a synthetic biography of Prof. Parnas, his influence on the organization of scientific life in interwar Poland, and presents his students and collaborators who created the so-called "The School of Parnassus". It shows how this figure still influences the thinking of Polish biochemists about their Society and the attitude towards biochemical communities abroad, especially in Ukraine, which owes as much to Prof. Parnas as Poland does.
State management of anti-corruption processes: Theoretical, methodological, political and legal aspects
Authors:   Tambov branch of RANEPA under the President of the Russian Federation, Gavryushina Vera S. , Trifonov Yuri N. ,   Tambov branch of RANEPA under the President of the Russian Federation
Published: March 2024

The authors explore current problems of public administration of processes related to combating corruption, focusing on its theoretical, methodological, political and legal aspects. This is due to the fact that the society has formed a demand to ensure resolute counteraction to corruption, the spread of which creates an existential threat to Russian society. Therefore, it is necessary to combine the efforts of the government, business and civil society, including the scientific and expert community, aimed at solving this problem. Special attention is paid to the search and use of adequate theoretical and methodological approaches to the corruption problem, which has a complex nature, and the development of effective anti-corruption technologies. In this regard, a critical analysis was carried out and the inconsistency of biologizing and sociologizing interpretations of corruption, recognition of its “eternal” nature, etc., was shown, which leads to the development and use of ineffective anticorruption tools. On the contrary, heuristic possibilities of dialectical, concrete-historical and interdisciplinary approaches to the development of anti-corruption system are postulated. It is concluded that the deep origins, causes and factors that generate corruption in modern Russia are rooted in the model of social structure chosen in the 1990s. The necessity of developing and implementing an updated state anti-corruption policy in the context of ongoing and expected socio-economic and political transformations is substantiated. It is shown that the updated anti-corruption policy should be implemented in dialectical unity with the state policy on the preservation and strengthening of traditional spiritual and moral values.
Social interactions in the higher education system in the context of informatization of society
Authors:   Penza State University, Naydenova Lyudmila I. , Shchanina Ekaterina V. ,   Penza State University
Published: March 2024

Informatization of various aspects of social life and digitalization of economic sectors changed the content of the activities of many social institutions. This touched upon the problem of social interactions in modern higher education. Practical actions in the aspect of digitalization of higher education require social reflection for their effective regulation. The purpose of the article is to determine the factors influencing the implementation of the main institutional functions of higher education through social interactions of teachers and students in the context of digitalization of higher education (in particular, during the transition to distance learning). The article discusses theoretical approaches to understanding digitalization processes, which are complemented by the well-known approaches to studying the essence of social interactions. Systemic and institutional approaches were used. The theoretical analysis of the features of social interactions using digital technologies is supplemented by a secondary analysis of sociological research on the problems of digitalization of the higher education system, the introduction of digital technologies and distance learning at universities, and the results of a sociological survey of the students at Penza State University (April–May 2020). The article describes the experience of leading universities in the use of artificial intelligence, big data analytics and the work of neural networks in university activities. On the basis of the conducted research and secondary data analysis, it was concluded that the institutional function of knowledge transfer in the higher education system was quite successfully performed in the new learning conditions. The possibilities of social interactions and communications with teachers and management structures of universities are influenced by technological, educational, organizational and communication factors. Under their influence, the professional and general cultural competencies of university graduates will be formed, which are prerequisites for them to occupy new social statuses after graduation.
“Sovereign” future of Russian education as a political and managerial problem
Authors:   Saratov State University, Afanasyeva Kristina A.
Published: March 2024

The article forecasts the risks for the implementation of a new strategy of educational reforms in our country, which arise in the wake of uncertainty with the key idea of this strategy – i.e. to make the Russian education system “sovereign”. An analysis was carried out of possible options for the reaction of managers responsible for the development and implementation of this strategy, as well as teaching staff and interested citizens to the proposal from the state to abandon the Bologna system of organizing educational space and make the new education system fundamentally different, but, at the same time, to preserve “all the best” from the previous Bologna system in the new sovereign system. The author’s opinion is substantiated that uncertainty with the theoretical foundations of the new state policy strategy will inevitably provoke the desire of individual subjects of educational policy to interpret the meaning of this strategy in their own way and attempts to impose their understanding on other subjects. In such conditions, it is likely that new reformswill turn from a tool for consolidating civil society around the sovereign interests of the Russian state into a challenge to stability in the internal politics of the state and in civil life.
On Some Aspects of Social Protection of Special Military Operation Participants
Authors:   Associate Professor of the Department of Entrepreneurial and Financial Law of the Law Institute of the Baikal State University, PhD (Law), Trofimov Sergey V.
Published: March 2024

The article studies theoretical and practical issues of the legal regulation of social protection of Russian citizens taking part in military actions in the south-east of Ukraine within the framework of the special military operation. The author proves that there is a need for the immediate development of new and amendment of the existing provisions of tax laws that regulate the application of legal mechanisms of social support of special military operation participants and their family members. Attention is paid to the existing undervaluation of seriousness of the current position, gaps and discrepancies in regulations that govern issues of social protection of Russian citizens fighting to protect the interests of the Russian state.
Legal and Organizational Determinants of the Structure of Military Ministries and Departments
Authors:   Associate Professor of the Saint Petersburg Military Institute of National Guard Troops, PhD (Law), Glukhov Evgeny A.
Published: March 2024

The article analyzes the regulatory regulation of the construction of federal state bodies, which provide for military service. It is noted that the structure of any military department should be derived from the functions performed by it and aimed at their optimal performance. Since it should dynamically change along with the development of military science, means and methods of warfare, it is not appropriate to fix the structure of military organizations in a nor-mative manner, at the same time it should be defined in order to clarify the powers of military structures in relations with other persons and the most optimal achievement of their goals.
Barrack Hooliganism (Art. 335 of the Criminal Code of the Russian Federation). Article 1. On the History and Essence of the Issue
Authors:   Head of the Department of Judicial, Prosecution and Investigative Activities of the A.S. Griboyedov Moscow University, Professor of the Department of Theory and History of State and Law of the Institute of Social and Humanitarian Education of the Moscow Pedagogical State University, LL.D., Professor, Kolokolov Nikita A.
Published: March 2024

The author studies the concept of barrack hooliganism (abuse, bullying, hazing) understood as the aggregate of obviously illegal demonstrative attempts of some military servicemen to establish control over other military servicemen by applying mental, physical and sexual violence (shadow law). An in-depth study of this subject gives grounds to conclude that barrack hooliganism is not just a historical category but an international one.
Izrael Rabon – cudowne dziecko żydowskiej Łodzi
Authors: Olejnik Izabela
Published: March 2024

W artykule omówiono życie i twórczość Izraela Rabona, jednego z najważniejszych łódzkich pisarzy literatury żydowskiej oraz jego udział w tworzeniu środowiska literackiego w Łodzi. Przedstawiono najważniejsze jego dzieła: Ulicę, która jako jedyna z całej jego twórczości została przełożona na język polski, Bałuty oraz reportaż zatytułowany Szkice z 1939 roku.
Títulos de Participación en el Patrimonio (TPP)
Authors: Baldeón Francisco , Montes de Oca Santiago
Published: March 2024

El presente artículo estudia al Título de Participación en el Patrimonio, un instrumento financiero de equity que otorga a su tenedor una participación específica en los resultados de la empresa emisora sin concederle la calidad de accionista, que, a pesar de estar previsto expresamente en la ley peruana y en el derecho comparado, ha sido olvidado en la práctica financiera.El objetivo de este estudio es entender las ventajas competitivas del Título de Participación en el Patrimonio tanto para los emisores como para los tenedores, las que lo convierten en un instrumento financiero a considerar en el mercado de capitales.
Figuraciones de la prisión en Escalas, de César Vallejo
Authors: Flores Heredia Gladys
Published: March 2024

El artículo propone describir, analizar e interpretar la representación del espacio carcelario en los relatos que aluden al tema de la prisión y que forman parte del libro Escalas (1923), de César Vallejo. Tras un registro de las alusiones discursivas que se hacen del espacio carcelario en relatos como “Muro noroeste”, “Muro antártico”, “Muro este”, “Muro dobleancho”, “Alféizar” y “Liberación”, se puede dar cuenta de que existen dos modelos de prisión claramente caracterizados: uno, que administra el espacio para triturar la experiencia del reo al punto de incapacitarlo; y otro, que también gestiona el espacio carcelario, pero para hacer del reo un trabajador, un sujeto de producción. Estos dos modos de representar el espacio carcelario proponen una crítica a cómo se encara la cuestión del encarcelamiento. El narrador cuestiona que se privilegien solo medidas punitivas, ya que quienes están recluidos no son todos culpables o criminales. Su crítica ofrece indicios para pensar en el reo con presupuestos que atiendan su dimensión sensible, creativa y productiva.
El símbolo de la estrella en la poesía juvenil de Federico García Lorca
Authors: Romo Ávila Cristina
Published: March 2024

En la primera poesía de Federico García Lorca, se busca a Dios de manera recurrente y alegórica. Esta indagación parte de una concepción pesimista del destino del hombre en la tierra, la cual impulsa la esperanza de encontrar una vida más allá de esta. Ese transcurso metafórico se compone de un ir y venir entre los extremos de la finita vida material y de la vida espiritual (o de la duda y de la creencia). Ambos extremos son representados por dos símbolos que desde épocas antiguas han aludido a la muerte y al mal (la oscuridad) y a la esperanza y a la vida (la luz). Este espacio está dedicado a la interpretación minuciosa de los significados posibles del símbolo de la estrella, representación polisémica y cambiante de la esperanza de escapar de la mortalidad humana.
Irreconcilable judgments in the EU Regulations
Authors: Tičić Martina
Published: March 2024

Despite the fact that the abolition of exequatur seems to have become the norm under the EU regulations dealing with monetary claims, all of the regulations that fall under this category still preserve some grounds for refusal of enforcement of judgments. One of the refusal grounds which remained, even in the regulations which otherwise abolished all possibility of refusal, is the ground of irreconcilability with another judgment. Despite its importance, this refusal ground can sometimes still be quite complex to interpret. This paper thus analyses the notion of ‘irreconcilable judgments’, clarifying the remaining difficulties in interpretation. Moreover, it compares the diverging solutions offered in different regulations, and ultimately proposes a potential reform.