bluuebunny/crossref_metadata_2025 huggingface dataset:
Kırık Camlar Teorisinin Erdemli Raporlama (Whistleblowing) Davranışına Etkisi: Yükseköğretim Çalışanları Üzerinde Bir Uygulama
Authors: ALTINTAŞ Mustafa
Published: January 2023

Bu çalışmanın amacı kırık camlar teorisinin erdemli raporlama (whistleblowing) davranışına etkisini araştırmaktır. Alan yazında iki kavramın birbiriyle ilişkisinin araştırıldığı herhangi bir çalışmaya rastlanmamıştır. Araştırmanın bu açıdan alan yazına katkı sağlayacağı düşünülmektedir. Tanımlayıcı nitelikte olan bu çalışma, Yozgat Bozok Üniversitesi’nde görev yapan idari ve akademik personel üzerinde 2021 yılında gerçekleştirilmiştir. Araştırmada basit tesadüfi örneklem yöntemi seçilmiş olup, çalışmaya katılmayı kabul eden 405 kişiye anket uygulaması yapılmıştır. Veri toplama aracı olarak Örgütsel Kırık Camlar Ölçeği ve Erdemli Raporlama Ölçeği kullanılmıştır. Bektaş ve arkadaşları (2019) tarafından geliştirilen ve örgütlerdeki bu davranışı belirlemeye çalışan ölçekte bireysel ve yönetsel olmak üzere iki boyut ve 13 soru bulunmaktadır. Celep ve Konaklı (2012) tarafından geliştirilen Erdemli Raporlama Ölçeği ise içsel, dışsal, destekçi ve gizli olmak üzere 4 boyuttan ve 16 sorudan oluşmaktadır. Araştırmadan elde edilen verilerin analizi SPSS 22.00 paket programıyla yapılmıştır. Araştırmadan elde edilen bulgulara göre örgütsel kırık camlar teorisinin erdemli raporlama (whistleblowing) davranışı üzerinde etkisi olduğu sonucuna ulaşılmıştır. Ayrıca sosyo-demografik değişkenler ile ölçek puanları arasında anlamlı ilişkilerin olduğu belirlenmiştir.
Erzurum/Aşkale Turaç Kaleleri
Authors: DUMLU Adem , BİNGÖL Burak
Published: January 2023

Erzurum ili Aşkale ilçesi, ortalama 1800 m rakımı ile oldukça yüksek bir bölgedir. Genelde küçük tarım alanları ve yüksek platolardaki yaylalarda yapılan hayvancılık bölge halkının ana geçim kaynağıdır. İlçeden geçen Karasu Irmağı ve kolları ise bölgeye hayat vermektedir. Kafkasya ve İran’dan gelen yolların batıya ve kuzeye devam etmesi için ilçe kavşak konumundadır. Bölgede uzun yıllardır yapılan yüzey araştırmaları ve arkeolojik kazılar neticesinde bölgenin Kalkolitik Çağ’dan itibaren yerleşim gördüğü bilinmektedir. Makalenin de konusu olan Turaç Kalesi I-II incelendiğinde kalelerin Tunç Çağı’nda yoğun olarak yerleşim gördüğü söylenebilir. Keramik verileri, mimari izler, konum ve diğer merkezlerle olan karşılaştırmalar bunu desteklemektedir. Turaç I Kalesi boyut ve mimari detay olarak bölgedeki diğer kalelere nazaran daha büyük ve mimari olarak daha iyi durumdadır. Turaç II Kalesi’nin ise Turaç I Kalesi’ne destek amaçla inşa edildiği söylenebilir. Kalelerin Aşkale, Tercan ve Çat ilçe sınırlarında bulunan vadi yollarını kontrol etmesi, su kaynaklarına ve otlaklara hâkim olması stratejik önemini artırmaktadır. Çalışmada kalelerin coğrafi durumu, mimari yapısı, keramik verileri incelenmiş ve diğer merkezlerle karşılaştırılması yapılmış ve değerlendirilmiştir.
Beden Eğitimi ve Spor Öğretmeni Adaylarının Öğretmenliğe İlişkin Tutumları: Karma Yöntem Araştırması
Authors: KORUCUK Murat , HAVADAR Tarkan
Published: January 2023

Bu çalışmada beden eğitimi ve spor öğretmeni adaylarının öğretmenliğe ilişkin tutumlarının belirlenmesi ve öğretmen adaylarının mesleki tutumlarının çeşitli değişkenlere (cinsiyet, öğretmenlik eğitimini alma biçimi, bölüm seçme nedeni, not ortalaması, sınıf, aylık ortalama gelir ve anne-baba eğitim durumu) göre farklılaşıp farklılaşmadığının incelenmesi amaçlanmıştır. Çalışmada verilerin detaylı bir biçimde değerlendirilmesi için karma araştırma desenlerinden ardışık açıklayıcı desen kullanılmıştır. Araştırmanın nicel kısmında tarama modelinden yararlanılmıştır. Nitel kısmında ise durum çalışması deseni kullanılmıştır. Çalışmanın nicel araştırma grubu 325 beden eğitimi ve spor öğretmeni adayından oluşmaktadır. Nitel araştırma grubu ise maksimum çeşitlilik örnekleme yöntemi kullanılarak oluşturulan 12 katılımcıdan meydana gelmektedir. Nicel veri toplama aracı olarak Kahramanoğlu vd. (2018) tarafından geliştirilen “Öğretmenlik Mesleğine Yönelik Tutum Ölçeği-ÖMYTÖ” kullanılmıştır. Nitel veri toplama aracı olarak ise araştırmacı tarafından geliştirilmiş olan görüşme formundan yararlanılmıştır. Nicel veri analizinde nonparametrik tekniklerden yararlanılırken nitel veri analizinde betimsel analiz uygulanmıştır. Çalışma sonucunda beden eğitimi ve spor öğretmeni adaylarının mesleki tutumlarının olumlu ve yüksek düzeyde olduğunu sonucuna ulaşılmıştır. Diğer taraftan beden eğitimi ve spor öğretmeni adaylarının bölüm seçme nedenleri, not ortalamaları ve sınıf değişkeni ile öğretmenliğe ilişkin yönelik tutum düzeylerinin anlamlı düzeyde farklılaştığı tespit edilmiştir. Çalışmada ulaşılan nitel bulguların nicel bulguları desteklediği de tespit edilmiştir. Çalışma sonuçları kapsamında araştırmacılar ve uygulayıcılar için çeşitli öneriler sunulmuştur.
Tasarımsız Mimariler! Türkiye’deki Özel Eğitim Uygulama ve/veya Meslek Okulları
Authors: ÇALIKOĞLU Burcu , YAMAN GÜLMEZ Hatun , TEPE Serhat
Published: January 2023

Bu çalışmanın amacı, Türkiye’deki özel eğitim uygulama ve/veya meslek okullarının mimari açıdan değerlendirmelerini yaparak ülke profilini ortaya koymaktır. Keşfedici araştırma niteliğindeki bu çalışmada, yakınsak paralel karma (NİC + NİT) desenden yararlanılmıştır. İlk olarak, mimari erişilebilirliğin özel gereksinimliler bağlamındaki çerçevesi (1) güvenlik, (2) bağımsızlık ve (3) sosyallik özellikleri ile yapılandırılmıştır. Çalışmanın nicel verilerini, bu üç özelliği kapsayan 65 maddelik Özel Eğitim İçin Mimari Yeterlilikler Gözlem Formu (ÖEMYGF), nitel verilerini ise okul binalarının fotoğrafları sağlamıştır. ÖEMYGF, İzmir’deki bir devlet üniversitesinde “Özel Eğitim Kurumlarında Gözlem” adlı dersi alan öğrenciler tarafından, Akdeniz Bölgesinde Antalya’da 2, Mersin’de 1, Osmaniye’de 1; Doğu Anadolu Bölgesinde Muş’ta 1, Şırnak’ta 1, Van’da 1; Ege Bölgesinde Balıkesir’de 1, Denizli’de 1, İzmir’de 5; Güney Doğu Anadolu Bölgesinde Batman’da 1, Bitlis’te 1, Diyarbakır’da 1, Mardin’de 1, Şanlıurfa’da 2; İç Anadolu Bölgesinde Ankara’da 1, Yozgat’ta 1 olmak üzere 22 okulda uygulanmıştır. Elde edilen veriler ışığında, ülkemiz özel eğitim mimarisinin yeterliliğini orta düzeyde sağladığı (ort=35,31); en çok güvenlik (ort=12,96); en az bağımsızlık (ort=10, 59) özelliğine önem verilerek yapılandığı gözlemlenmiştir. Bina konfigürasyonu ile mimari yeterlilik arasındaki ilişkinin zayıf düzeyde (r=0,38) olduğu hesaplanmıştır. Özel eğitimi kimliksizleştiren fabrikasyon yapıların azaltılmasına yönelik bir vizyon geliştirilmesi amacıyla, Eğitim ve Mimarlık Fakültelerindeki lisans programlarına değer odaklı okul mimari ve tasarımlarına yönelik derslerin yerleştirilmesine ve bu derslerin sayılarına ilişkin önerilerde bulunulmuştur.
Sustainability Communication: Analysis of Sustainable Development Goals 2030 Practices of the Hotel Chains in Turkey
Authors: ÖZLÜ Özden
Published: January 2023

In this research, it has been examined whether the hotel chains serving in Turkey implement the United Nations Sustainable Development Goals 2030 in their sustainability practices by acting as green hotels and how they attempt to attract guests with their sensitivity towards the environment. The sample includes three Turkish and three international hotel chains having the highest number of rooms. The data between 2019 and 2021 about which goals the hotel chains adopt have been obtained from their sustainability reports on their web pages or on the Internet and analyzed through web content analysis. As a result of the study, it was found that two of Turkish hotel chains do not adopt any of the 17 goals; the other adopts 15, two of the international hotel chains adopt 12 and one adopts 6 goals. None of the hotel chains have submitted their reports on their own web pages directly. Instead, some have a link directing visitors to their reports on the Internet others do not, but they hold their reports on the World Wide Web. Consequently, it has been observed that neither national nor international hotel chains have a tendency to use their hotel web pages for sustainability communication.
Ömer Seyfettin’in Hikâyelerinde Millî Kimlik İnşasında Annelerin Rolü
Authors: TARAKÇI Gülsüm
Published: January 2023

Türk edebiyatında seçkin bir yere sahip olan Ömer Seyfettin, gerek hikâyelerinde gerekse makalelerinde millî şuurun önemi üzerinde durur. Olması gerekeni kimi zaman olumsuz örnekler üzerinden veren kimi zaman da olduğu gibi kurgu dünyasına taşıyan ve Türk milleti adına doğruyu/iyiyi/güzeli okura sezdirmeye çalışan Ömer Seyfettin, millî şuurun millî hafızayı canlı tuttuğuna ve kimlik inşasının oluşmasına katkı sağladığına inanır. Bu bağlamda onun hikâyelerinde kimlik inşasının gerçekleşmesine katkı sağlayan en önemli unsurlardan birisi, annelerdir. Anneler, çocuğu dünyaya getirmenin ötesinde kültürel belleğin taşıyıcısı ve aktarıcısı olmaları nedeniyle değer taşırlar. Çalışmada üzerinde durulacak hikâyeleriyle çocuğa dil, tarih ve din şuurunu veren ya da veremeyen, çocuğu ait olduğu toplumun maddî ve manevî değerleriyle yetiştiren veya yetiştiremeyen, çocuğa millî ve dinî aidiyet duygusunu kazandıran ya da kazandıramayan anneler üzerinden kimlik inşasında annelerin taşıdığı önemi ve rolü vurgulayan Ömer Seyfettin, aynı zamanda Türk ve yabancı kadınlarla yapılan evliliklerin çocuğun kimlik inşasında ne derece etkili olup olmadığı üzerinde de durur. İlk Namaz, Fon Sadriştayn’ın Karısı, Fon Sadriştayn’ın Oğlu ve Piç hikâyelerinin ele alındığı bu çalışmada hikâyelerdeki anneler ve çocuklar arasında yapılacak olan karşılaştırmalarla anne-çocuk-kimlik inşası arasındaki ilişki tespit edilmeye çalışılacaktır.
Psicoeducación
Authors:   Universidad del Azuay, Chocho-Orellana Ximena , Reyes-Fernández-de-Córdova Norma ,   Universidad del Azuay, Cordero-Cobos Lucía ,   Universidad del Azuay
Published: January 2023

La Escuela de Psicología Educativa de la Universidad del Azuay presenta su primer libro “Psicoeducación”. Con el propósito de aportar a las instituciones que han apoyado como centros de prácticas pre-profesionales, se pretende responder al interés demostrado por docentes y representantes de niños de segundo, tercero y cuarto de Educación General Básica, en edades comprendidas entre los 6 y 9 años, sobre cómo abordar las diferentes situaciones que se presentan en los hogares y en las aulas de clases. El proceso de educación depende de la realidad familiar, comunitaria y social; y reclama un acompañamiento flexible, continuo y transformador, para lo cual debemos estar informados. Por lo tanto, hemos considerado la herramienta psicoeducativa como un medio para llegar a docentes y representantes con información sobre el desarrollo humano en el área familiar, social y escolar. 54 páginas ISBN: 978-9942-822-55-0 e- ISBN: 978-9942-822-56-7
The Relationship between the Dialysis Volume and Total Fluid Infused in Patients Undergoing Renal Transplantation
Authors: Chu Ran , Cao Zhongping
Published: January 2023

Background: Volume therapy is important to keep the graft kidney function and organ perfusion during kidney transplantation, and almost all patients undergo dialysis before operation. The study is designed to show whether the dialysis volume is more closely associated with the total fluid infused during renal transplantation. Methods: Thirty patients undergoing kidney transplantation were included. The dialysis volume was recorded just before operation. Stroke volume variation (SVV) was kept under 13, and central venous pressure (CVP) was kept between 8 to 12 mmHg before the reperfusion of the graft kidney until the end of the operation. The total fluid infused was recorded at the end of the operation. Results: All patients included in the study underwent successful renal transplantation and recovered to normal after operation. The MAP, CVP, CO before graft renal reperfusion and 30 minutes after reperfusion increased significantly than that of after anesthesia, while SVV before graft renal reperfusion and 30 minutes after reperfusion decreased significantly than that of after anesthesia. The total fluid infused was significantly different from the dialysis volume, and was not correlated with the dialysis volume. Conclusions: These data suggested that fluid therapy is necessary to the recovery of graft renal function, and that the dialysis volume, as part of the volume lost before operation, cannot be used to assess the need of total fluid infusion.
Subnormal Immunity to Inactivated Poliovirus Vaccine (IPV) in Previously Vaccinated Human Immunodeficiency Virus (HIV) - Infected Children
Authors: Choudhury Shahana A
Published: January 2023

Introduction: Minimal data exists regarding prevalence of immunity to inactivated poliovirus vaccine (IPV) in previously vaccinated HIV-infected children. Methods: Antibody titers to IPV against serotypes (ST) 1, 2 and 3 following 3-doses (primary series) and 4th and 5th doses (booster) were examined in 59 children who were born to HIV-infected mothers. Eight of those children tested negative for HIV by DNA PCR and served as the controls for the 3rd and 4th dose recipients. Anti-polio 1, 2, 3 antibody titers (1/dil) was measured by neutralization assay at Specialty Laboratory in New Jersey. Correlate of protective immunity (PI) was defined as antibody titer >1:8 for all serotypes. ST specific PI was correlated with the T cell counts and clinical disease categories within the HIV-infected children. PI status was compared between the HIV- infected and HIV- uninfected children and between the numbers of vaccine dose recipients within the HIV-infected children. Results: Mean age of children at the time of vaccination was 6.6, 18.6 and 66.5 months in the 3rd, 4th and 5th dose recipients, respectively. The mean age of the HIV-infected and HIV- uninfected children was comparable in the 3-dose group. Among the 3rd and 4th dose recipients, prevalence of PI to all 3 ST was significantly (p= 0.002/ST1, 0.002/ST2 and 0.01/ST3) lower in the HIV-infected, compared to their uninfected counterparts; Within the HIVinfected children, prevalence of PI to ST 1 and 2 was around 7-10 percent for all dose recipients; and 28 percent to ST3 for the 5th dose vaccine recipients. The CD4 count was found to be significantly (p=0.009) lower (362/mm3) in the 5th dose compared to the 3rd dose vaccine recipients (1072 /mm3). Conclusion: A significantly high proportion of HIV- infected children may remain unprotected against all ST of IPV even after their booster doses and thus may remain at risk for infection with all 3 ST of poliovirus when exposed to recipients of the live oral polio vaccine worldwide. Global implementation of IPV over OPV may be considered to prevent resurgence of poliovirus disease in the growing population of immunocompromised patients. Extra vigilance in the maintenance of protective immunity to poliovirus serotypes and surveillance of disease in the immunocompromised host may be deemed necessary for prevention of disease occurrence and timely diagnosis and treatment.
Antioxidant and Hepatoprotective Activity of Leaf Extract of Smilax Anceps Wild
Authors: A Shorinwa Olusayo , D Shatange Dorothy
Published: January 2023

Introduction: Smilax anceps leaf is used for general healing of the body in traditional medicine. The aim of this study was to investigate the in-vitro antioxidant potential and in-vivo hepatoprotective activity of the ethanol leaf extract of Smilax anceps against carbon tetrachloride induced hepatotoxicity. Materials and Methods: Preliminary phytochemical screening and acute toxicity were determined. In-vitro antioxidant activity of the plant was evaluated using 2, 2-diphenyl-1-picryl-hydrazyl (DPPH), reducing power activity, nitric oxide scavenging, and lipid peroxidation scavenging activity assays. In- vivo hepatoprotective activity was determined using albino rats, divided into groups of six comprising of 5 animals each vis the control, CCl4, extract 250,500 and 1000mg/kg, and silymarin 100mg/kg. Treatments were done for seven days and carbon tetrachloride dissolved in olive oil was administered on the seventh day. Biochemical analysis was performed to assay the levels of aspartate aminotransferase (AST), alanine amino transaminase (ALT), alkaline phosphatase (ALP), albumin (ALB), total protein (TP) and Total bilirubin (TB) with histological examination of the liver. Phytochemical screening showed the presence of saponins, flavonoids, tannins, carbohydrates and steroids/ terpenoids. Results: The extract showed significant (P<0.01) scavenging activity against DPPH, reducing power activity, nitric oxide scavenging, and lipid peroxidation. There was a statistically significant (P<0.05) decrease in total bilirubin (TB), alanine amino transaminase (ALT) and alkaline phosphatase (ALP). Conclusion: The findings of this study showed that the ethanol leaf extract of S. anceps possesses significant antioxidant and hepatoprotective which might be due to the presence of flavonoids.
ANALYSIS OF STUDENTS’ ERRORS OF CLASS VIII MTs ATH-THOHIRIYYAH IN SOLVING CIRCLE MATERIAL PROBLEMS BASED ON NOLTING THEORY
Authors: Izza Aini Zulfa , Mardhiyana Dewi
Published: January 2023

This research is a qualitative descriptive research that aims to describe the types of student errors and the factors that cause students making mistakes in solving problems about circle material based on Nolting's theory. This research involved 25 students of class VIII B MTs Ath-Thohiriyyah Watusalam for the academic year 2021/2022 through test and interview methods. The results showed the types of student errors were: 65.6% concept errors, 63.2% test-taking errors, 57.6% misread-directions errors, 56% careless errors, 8% study errors, and 6.4% application errors. Factors that cause students making mistakes because of they are nervous, don’t understand the questions, don’t study before doing the test, don’t take care, don’t recheck the answers before they are collected, don’t understand the formula, don’t understand the operating steps, dislike mathematics, and study habits by skimming. without understanding.
THE INFLUENCE OF FLIPPED LEARNING MODELS USING THE BRAINSTORMING METHOD TO THE MATHEMATICAL PROBLEM SOLVING ABILITY
Authors: Barida Nada Haristiani , Rahayu Sri
Published: January 2023

The purpose of this study is to determine the influence of flipped classroom learning models using  the brainstorming method  on mathematical problem solving ability in geometry transformation materials.  The population in this study was all class XI students of SMAN 1 Taman Sidoarjo.  Dari teknik purposive sampling obtained samples of class XI IPA 1 and XI IPA 2.  The data collection method in this study is the test and documentation method. Data analysis using normality, homogeneity, and t-tests. By data analysis using t-test obtained  with a significant level of 0.05. This shows that it is greater than the value , so in conclusion there is an influence of  the traditional flipped classroom type flipped learning model  using the brainstorming method on the ability to solve mathematical problems in geometry transformation material in class XI SMAN 1 Taman Sidoarjo.
STUDENTS' GEOMETRY THINKING ON CIRCLE MATERIAL BASED ON VAN HIELE'S THEORY
Authors: Prafianti Rayinda Aseti , Novitasari Novitasari , Ambarwati Dian Novi
Published: January 2023

The purpose of this study was to describe students' geometric thinking skills on circle material based on Van Hiele's theory (Visualization, Analysis, Informal Deduction, Deduction, Rigor). The subjects of this study were 3 students of class IX-A SMP Hang Tuah 4 Surabaya based on their initial mathematical abilities (high, medium, and low). The initial mathematical ability data was obtained from data on report cards for the even semester of the 2021-2022 academic year and based on the considerations of the mathematics teacher for class IX-A. This type of research is descriptive qualitative research. Collecting data in this study used tests and interviews. The test instrument used in this study was a circular geometry test in the form of mathematical questions with circle material arranged based on the Van Hiele indicator without stage 4 (Rigor) with the consideration that the research was conducted in class IX SMP so students have not been able to understand the material at stage 4 (rigor). Student with high initial mathematical abilities, geometric thinking abilities is already at stage 2 (informal deduction). Student with medium mathematical abilities, geometric thinking skills is at stage 2 (informal deduction). Student with low mathematical abilities, geometric thinking skills is at stage 0 (visualization).
A Practical Review of Insulin Pen Devices
Authors: Pearson Teresa L.
Published: January 2023

Since the advent of insulin pens in 1985, there have been ongoing improvements providing several advantages over the traditional vial and syringe method of insulin delivery. In recent years, pens have become increasingly user-friendly, and some models are highly intuitive to use, requiring little or no instruction. Despite this progress, there remains to be disparity in access to insulin pens to people with diabetes in various countries. There is a need for improved awareness of the benefits of insulin pens among healthcare professionals. Continual advances have been made to address patient needs such as improved technology to make them easier to use; less painful; more discreet and convenient; and more accuracy for small doses of insulin, as well as the incorporation of a memory function, all contribute to an insulin delivery device that allows the patient to better manage their diabetes anytime and anyplace, without the bulk and challenge of carrying a vial and syringe. These advances have resulted in increased patient satisfaction with insulin pens and most importantly, all of these benefits improve adherence and result in improved clinical outcomes. This review highlights these benefits of insulin pen use and presents the issues to be considered when helping patients decide on the insulin pen that will best suit their needs.
The Full Picture of Ulcerative Colitis: The Burden, the Patient, the Treatment
Authors: Johnson Allan
Published: January 2023

Ulcerative colitis (UC) carries a significant, progressive disease burden that is often underestimated or misinterpreted by healthcare providers. Adverse outcomes have a major impact on patient quality of life, with a significant burden of symptoms both during and between inflammation flares. Chronic, uncontrolled disease leads to epithelial fibrosis and ‘lead pipe’ colon, dysplasia, and potential colonic cancer. Healthcare providers and patients share similar treatment goals, even if these are not verbalised in the same way, and clinicians need to fully understand the issues most important to patients. Understanding and collaboration can improve identification of meaningful treatment goals and overall disease management. In real-world practice, patients should be categorised according to disease characteristics and prognosis, and managed with appropriate, optimised therapies. Early, top-down management should be implemented in high-risk patients and all patient-centric therapeutic decisions made within the context of a full benefit/risk assessment.
Risks of Using Bedside Tests to Verify Nasogastric Tube Position in Adult Patients
Authors: Ni Melody , Priest Oliver , Phillips Lawrence D. , Hanna George B.
Published: January 2023

Nasogastric (NG) tubes are commonly used for enteral feeding. Complications of feeding tube misplacement include malnutrition, pulmonary aspiration, and even death. We built a Bayesian network (BN) to analyse the risks associated with available bedside tests to verify tube position. Evidence on test validity (sensitivity and specificity) was retrieved from a systematic review. Likelihood ratios were used to select the best tests for detecting tubes misplaced in the lung or oesophagus. Five bedside tests were analysed including magnetic guidance, aspirate pH, auscultation, aspirate appearance, and capnography/colourimetry. Among these, auscultation and appearance are non-diagnostic towards lung or oesophagus placements. Capnography/ colourimetry can confirm but cannot rule out lung placement. Magnetic guidance can rule out both lung and oesophageal placement. However, as a relatively new technology, further validation studies are needed. The pH test with a cut-off at 5.5 or lower can rule out lung intubation. Lowering the cut-off to 4 not only minimises oesophageal intubation but also provides extra safety as the sensitivity of pH measurement is reduced by feeding, antacid medication, or the use of less accurate pH paper. BN is an effective tool for representing and analysing multi-layered uncertainties in test validity and reliability for the verification of NG tube position. Aspirate pH with a cut-off of 4 is the safest bedside method to minimise lung and oesophageal misplacement.
Coronary Artery Bifurcation Lesions: A Review of Contemporary Techniques in Percutaneous Coronary Intervention
Authors: Fuchs Felipe , Džavík Vladimír
Published: January 2023

Percutaneous intervention of coronary bifurcation lesions continues to challenge interventional cardiologists. Nonetheless, the past decade has seen an explosion in the development of clinical novel techniques and well-conducted trials validating the relative efficacy and safety of these techniques. For the most part, consensus has emerged regarding the preferred technique, that being provisional stenting of the side-branch (SB), based on the results of several randomised trials that, with the exception of one, have shown no benefit of a two-stent approach, utilising any one of several techniques, including the crush, culotte, or other modifications. Only the double-kiss (DK) crush appears to confer better clinical outcomes, possibly because of the superiority of the technique in optimising access to the SB. Trial data are still pending regarding the efficacy of two-stent techniques in patients with complex SB lesions and with large-calibre SBs. The use of second-generation drug-eluting stents is associated with better results compared to historical data. Preliminary data from studies utilising dedicated bifurcation stents similarly shows favourable results. Bifurcation stenting using bioresorbable vascular scaffolds is at an early stage, with prospective trial data needed to validate this technology for the use in this subset of patients. Modern imaging tools such as intravascular ultrasound and optical coherence tomography, as well as physiological assessment of SB lesions, are now utilised in decision-making regarding stent strategy, though trial data showing better outcomes with routine use of these tools are lacking.
Key Advances in the Systemic Therapy for Soft Tissue Sarcomas: Current Status and Future Directions
Authors: Soman Neelesh , Hu James , Subbiah Vivek , Chawla Sant
Published: January 2023

Soft tissue sarcomas (STS) represent a heterogeneous group of diverse neoplasms of mesenchymal origin. Once relapsed from standard therapy, STS patients have limited treatment options especially those that present with advanced or metastatic disease. In this review article, we highlight recent clinical data that led to the US Food and Drug Administration (FDA) approval of pazopanib (Votrient®) for STS and regorafenib (Stivarga®, BAY 73-4506) in gastrointestinal stromal tumours. We also review ongoing safety/efficacy data for trabectedin (Yondelis®, ET-743), and data from clinical studies of ridaforolimus (AP23573; MK-8669) and palifosfamide (ZIO-201). We provide a list of some promising ongoing trials in soft tissue sarcomas including first line studies of TH-302 and trabectedin. Finally, our article delves into recent advances in our understanding of the molecular pathogenesis of STS and novel therapies that might be explored as treatment options for specific STS histologies.
Paediatric Scleroderma: Kids Are Not Just Little Adults
Authors: Li Suzanne C. , McCormick Quinn
Published: January 2023

The sclerodermas are autoimmune rheumatic diseases associated with pathological fibrosis of tissues. The two forms, localised scleroderma (LS [also referred to as morphoea]) and systemic sclerosis (SSC), have different patterns of organ involvement depending upon age of onset. Juvenile LS (JLS) has a poorer prognosis than adult-onset LS (ALS), while juvenile systemic sclerosis (JSSC) has a better prognosis than adult-onset SSC (ASSC).

Optimal care requires appreciating the major differences between paediatric- and adult-onset disease, as they affect treatment and management strategies. Because the majority of patients with JLS have deeper tissue involvement, systemic immunomodulator rather than topical treatment is needed to mitigate their risk for serious morbidity and functional impairment. JSSC initially has a lower frequency of vital organ involvement than ASSC, but organ involvement can progressively accrue over time, so prolonged, aggressive treatment regimens may be needed. The authors recommend the care team for patients with JLS and JSSC include a rheumatologist who will be experienced in assessing and monitoring the most common extracutaneous involvement (musculoskeletal), as well as other organ involvement. Long-term monitoring of these patients into adulthood is essential; JSSC is a lifetime disease, while JLS can relapse or smoulder, with the disease activity focused in the deeper tissues.

The purpose of this review is to provide a clinically focused overview of JLS and JSSC disease patterns, highlighting differences between paediatric and adult-onset disease. The authors will review current care recommendations for JLS and JSSC, and discuss some of the challenges for their care, and areas for future research.
Deleuze and AlphaGo
Authors: Lampert Jay
Published: January 2023

It is time to update Deleuze and Guattari's contrast between Chess and Go in the ‘Nomadology’ Plateau with a discussion of AlphaGo, the artificial intelligence that revolutionised Go in 2016. I focus less on the political issues in Go nomadology, central as they are, and more on smooth space and time. I explain and speculate on some details in Go strategy, as well as some processes of machine learning. The relations between human Go, computer Go, and smooth-time nomadology remain unsettled, in my view, but many resources for nomadological analysis open up for readers who learn to play, and program, Go.
Pengelolaan Aset Tetap Dalam Mewujudkan Opini Wajar Tanpa Pengecualian di Kabupaten Timor Tengah Utara
Authors: Nooraini Afni , Mamulak Chatarina De Ricci R. , Sinurat Marja
Published: January 2023

Laporan Keuangan Pemerintah Daerah (LKPD) Kabupaten Timor Tengah Utara selama lima tahun terakhir selalu memperoleh Opini Wajar Dengan Pengecualian (WDP) yang disebabkan beberapa faktor yaitu pengelolaan aset tetap yang belum memadai. Penelitian ini bertujuan untuk mengetahui pelaksanaan pengelolaan aset tetap, faktor penghambat dan faktor pendukung pengelolaan aset tetap serta upaya yang dilakukan dalam mengatasi hambatan sehingga terwujudnya Opini Wajar Tanpa Pengecualian (WTP). Metode penelitian yang digunakan adalah deskriptif kualitatif dengan pendekatan induktif. Penentuan informan yang digunakan ialah teknik purposive sampling. Teknik pengumpulan data yang dilakukan dengan wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa pelaksanaan pengelolaan aset tetap di Kabupaten Timor Tengah Utara belum dilaksanakan secara maksimal karena terdapat beberapa kendala, ketidaklengkapan dokumen perolehan aset, kurangnya kompetensi SDM dalam menjalankan SIMDA BMD dan penerapan Standar Akuntansi Pemerintahan Berbasis Akrual serta koneksi jaringan SIMDA BMD yang bermasalah. Adapun faktor pendukung dalam pelaksanaan pengelolaan aset tetap, yaitu: kebijakan pengembangan SDM yang memadai, laporan hasil pengadaan BMD berjalan dengan baik serta perangkat pendukung yang memadai. Upaya yang dilakukan diantaranya: melengkapi dokumen perolehan aset tetap serta melakukan proses penilaian aset tetap secara tepat, melakukan pengajuan atas aset tetap yang hilang kepada MP TP-TGR, meningkatkan kompetensi bagi SDM serta Penerapan aplikasi SIMDA BMD yang dapat terintegrasi kepada seluruh OPD di Kabupaten Timor Tengah Utara.
Exploring the role of Big Data Analytics in Finance
Authors: Sakib S M Nazmuz
Published: January 2023

Big data information technology is one of the most popular and widely accepted form of technology. There are billions of various events taking place every day on this particular platform. One of those is financial industry which is deeply involved with this technology enjoying the perks and disadvantages as well. It is well known that millions of transactions, takes place on this platform in online form for this particular finance. Along with the benefits there comes risks. Therefore, the usage of big data information technology leaves its impacts on the industry in various forms. These impacts show the ways to deal with it and overcome the risks with the technology’s usage. On the basis of these mentioned facts, the major connection between the market of finance and the big data information technology will be discussed in brief in the literature review section.
TRAÇOS DA TEATRALIDADE BARROCA NO POEMA LADY LAZARUS, DE SYLVIA PLATH, NA MÚSICA E NO CLIPE BORN TO DIE, DE LANA DEL REY
Authors: Sirino Taylla Maria Machado , Dias da Silva Acir
Published: January 2023

No contexto da Literatura Comparada pretende-se analisar os traços da teatralidade barroca na poesia e na música. Tem-se como corpus o poema Lady Lazarus, de Sylvia Plath – que integra Poemas (2007) –, a canção e o videoclipe Born to die (2012), da cantora-compositora Lana Del Rey. Neste artigo, no contexto da arte barroca, parte-se do pressuposto de que os aspectos estéticos atribuíam elementos teatrais dentro de pinturas, nas quais a dramaticidade barroca transformava morte em espetáculo. Em termos teóricos, utiliza-se, especialmente, o livro Origem do drama barroco alemão (1984), de Walter Benjamin – e respectivo texto de apresentação inerente à tradução desse livro, realizada por Sergio Paulo Rouanet. Tanto a poetisa Sylvia Plath, quanto a compositora Lana Del Rey, retratam o renascimento ou a certeza de um certo tipo de existência após a morte, em suas composições artísticas. Ou seja, a criação poética de ambas, rica em metáforas e alegorias, representa cenas que trazem dramaticidade para a obra, construindo, assim, a teatralidade da morte com a intenção de representar a história-destino.
Effect of cold atmospheric microwave plasma (CAMP) on wound healing in canine keratinocytes
Authors: Lertpatipanpong Pattawika , Sillapachaiyaporn Chanin , Oh Garam , Kang Yeong-Hun , Hwang Cheol-Yong , Baek Seung Joon
Published: January 2023

Cutaneous wound healing is a biological process that occurs upon skin injury and involves different mechanisms to repair tissue damage. Improper healing or prolonged curation period of wound lesions may induce unpleasant complications. Cold atmospheric microwave plasma (CAMP) is an upcoming medical therapeutic option for skin infection and wound treatment. However, the molecular mechanisms of CAMP-mediated canine wound healing are not well characterized. Wound-healing activity was examined to elucidate the biological effects and molecular mechanisms of CAMP. Canine keratinocytes (CPEKs) were treated using CAMP, and their wound-healing activities were evaluated. The molecular mechanisms of that effect were examined, based on RNA-Seq analysis data, and verified using immunoblotting and polymerase chain reaction. It was found that the CAMP-treated cells exhibited a significant increase in cell migration evaluated by scratch assay in human keratinocytes (HaCaT) and canine keratinocytes (CPEK). Additionally, CAMP-treated CPEK cells showed a significant positive effect on cell invasion. The RNA-Seq data revealed that CAMP alters different genes and pathways in CPEK cells. Gene expression involved in the cell cycle, cell proliferation, angiogenesis, cell adhesion, and wound healing was upregulated in CAMP-treated cells compared with gas-activated media used as a control. The Hippo pathway was also analyzed, and the protein and mRNA levels of YAP were significantly increased in CAMP-treated cells. CAMP-treated CPEK cells indicated the downregulation of E-cadherin and upregulation of vimentin, Snail, and Slug at transcription and translation levels, contributing to a favorable effect on cell migration. Our findings suggested that CAMP treatment provided beneficial effects on the curative wound process through the induction of genes involved in wound healing, promotion of EMT, and increase in the molecular targets in the Hippo signaling pathway.
Fault detection method based on adversarial reinforcement learning
Authors: Junhuai Li , Yunwen Wu , Huaijun Wang , Jiang Xu
Published: January 2023

Fault detection is an essential task for large-scale industrial maintenance. However, in practical applications, due to the possible harm caused by the collection of fault data, the fault samples that lead to the labeling are usually very few. Most existing methods consider training unsupervised models with a large amount of unlabeled data while ignoring the rich knowledge that existed in a small amount of labeled data. To make full use of this prior knowledge, this article proposes a reinforcement learning model, namely, adversarial reinforcement learning in weakly supervised (WS-ARL), which performs significantly better by jointly learning small labeled anomaly data and large unlabeled data. We use an agent of the reinforcement learning model as a fault detector and add a new environment agent as a sample selector, by providing an opposite reward for two agents, and they learn in an adversarial environment. The feasibility and effectiveness of the model are verified by experimental analysis and compared the performance of the model with five state-of-the-art weakly/un-supervised methods in the hydraulic press fault detection task.
Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study
Authors: Wood Gregory , Johnsen Pia Hedegaard , Pedersen Anders Lehmann Dahl , Frederiksen Christian Alcaraz , Poulsen Steen Hvitfeldt , Bøtker Hans Erik , Kim Won Yong
Published: January 2023

Background

Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of RIC on left ventricular ejection fraction (LVEF) following infarct healing remains unknown.

Objective

To investigate whether RIC applied in the ambulance before PPCI can improve left ventricular (LV) function in STEMI patients 3 months following infarction.

Methods

Echocardiography was performed in a total of 694 patients from the CONDI-2 study a median of 112 days (IQR 63) after the initial admission. LVEF and LV end-diastolic and end-systolic volumes were calculated using the modified Simpsons biplane method of disks. LV global longitudinal strain (GLS) was estimated using 2-dimensional cine-loops with a frame rate > 55 frames/second, measured in the three standard apical views.

Results

There was no difference in the measured echocardiographic parameters in the RIC group as compared to the control group, including LV EF, LV GLS, tricuspid annular plane systolic excursion or left ventricular volumes. In the control group, 32% had an ejection fraction < 50% compared to 37% in the RIC group (p = 0.129).

Conclusion

In this largest to date randomized imaging study of RIC, RIC as an adjunct to PPCI was not associated with a change in echocardiographic measures of cardiac function compared to standard PPCI alone.
Higher risk of cardiovascular mortality than cancer mortality among long-term cancer survivors
Authors: Wang Zhipeng , Fan Zeyu , Yang Lei , Liu Lifang , Sheng Chao , Song Fengju , Huang Yubei , Chen Kexin
Published: January 2023

Background

Previous studies focused more on the short-term risk of cardiovascular (CV) death due to traumatic psychological stress after a cancer diagnosis and the acute cardiotoxicity of anticancer treatments than on the long-term risk of CV death.

Methods

Time trends in the proportions of CV death (PCV), cancer death (PCA), and other causes in deaths from all causes were used to show preliminary relationships among the three causes of death in 4,806,064 patients with cancer from the Surveillance, Epidemiology, and End Results (SEER) program. Competing mortality risk curves were used to investigate when the cumulative CV mortality rate (CMRCV) began to outweigh the cumulative cancer mortality rate (CMRCA) for patients with cancer who survived for more than 10 years. Multivariable competing risk models were further used to investigate the potential factors associated with CV death.

Results

For patients with cancer at all sites, the PCV increased from 22.8% in the 5th year after diagnosis to 31.0% in the 10th year and 35.7% in the 20th year, while the PCA decreased from 57.7% in the 5th year after diagnosis to 41.2 and 29.9% in the 10th year and 20th year, respectively. The PCV outweighed the PCA (34.6% vs. 34.1%) since the 15th year for patients with cancer at all sites, as early as the 9th year for patients with colorectal cancer (37.5% vs. 33.2%) and as late as the 22nd year for patients with breast cancer (33.5% vs. 30.6%). The CMRCV outweighed the CMRCA since the 25th year from diagnosis. Multivariate competing risk models showed that an increased risk of CV death was independently associated with older age at diagnosis [hazard ratio and 95% confidence intervals [HR (95%CI)] of 43.39 (21.33, 88.28) for ≥ 80 vs. ≤ 30 years] and local metastasis [1.07 (1.04, 1.10)] and a decreased risk among women [0.82 (0.76, 0.88)], surgery [0.90 (0.87, 0.94)], and chemotherapy [0.85 (0.81, 0.90)] among patients with cancer who survived for more than 10 years. Further analyses of patients with cancer who survived for more than 20 years and sensitivity analyses by cancer at all sites showed similar results.

Conclusion

CV death gradually outweighs cancer death as survival time increases for most patients with cancer. Both the cardio-oncologist and cardio-oncology care should be involved to reduce CV deaths in long-term cancer survivors.
Association between estimated pulse wave velocity and silent lacunar infarct in a Korean population
Authors: Zhou Yaping , Zhang Yu , Xu Gang , Shang Xiuli
Published: January 2023

Aims

Previous studies have proposed the estimated pulse wave velocity (ePWV) as a simple and cost-effective measure of arterial stiffness. Since arterial stiffness plays a role in the progression of silent lacunar infarct (SLI), our present work aims to evaluate the association between ePWV and the presence of SLI.

Methods

The present work was based on a cross-section study. Our study included 1,011 neurologically healthy Korean participants. The SLI was evaluated using brain magnetic resonance images (MRI). The ePWV was derived from a published equation using age and mean blood pressure (MBP). Logistic regression analyses were performed to investigate the association between ePWV and SLI. The linear relationship and robustness were evaluated using smooth curve fitting and subgroup analyses, respectively.

Results

The prevalence of SLI was 11.87%. After fully adjusting for covariates, per 1 m/s increase of ePWV casted 31% additional risk for SLI (P = 0.009). When dividing the ePWV into quartiles, the top quartile had 4.01 times risk compared with the bottom quartile. The increasing trend across the quartiles was statistically significant (P for trend < 0.001). Consistently, smooth curve fitting revealed that the risk of SLI elevated linearly with the increase of ePWV. Finally, subgroup analysis suggested that the association was robust in several sub-populations divided by age, sex, smoking, hypertension, diabetes mellitus (DM), coronary artery occlusive disease (CAOD), hyperlipidemia, and statin medication (all P for interaction > 0.05).

Conclusion

The current study revealed an independent and positive association between ePWV and the presence of SLI in a neurologically healthy Korean population.
Assessment of fractional flow reserve in intermediate coronary stenosis using optical coherence tomography-based machine learning
Authors: Cha Jung-Joon , Nguyen Ngoc-Luu , Tran Cong , Shin Won-Yong , Lee Seul-Gee , Lee Yong-Joon , Lee Seung-Jun , Hong Sung-Jin , Ahn Chul-Min , Kim Byeong-Keuk , Ko Young-Guk , Choi Donghoon , Hong Myeong-Ki , Jang Yangsoo , Ha Jinyong , Kim Jung-Sun
Published: January 2023

Objectives

This study aimed to evaluate and compare the diagnostic accuracy of machine learning (ML)- fractional flow reserve (FFR) based on optical coherence tomography (OCT) with wire-based FFR irrespective of the coronary territory.

Background

ML techniques for assessing hemodynamics features including FFR in coronary artery disease have been developed based on various imaging modalities. However, there is no study using OCT-based ML models for all coronary artery territories.

Methods

OCT and FFR data were obtained for 356 individual coronary lesions in 130 patients. The training and testing groups were divided in a ratio of 4:1. The ML-FFR was derived for the testing group and compared with the wire-based FFR in terms of the diagnosis of ischemia (FFR ≤ 0.80).

Results

The mean age of the subjects was 62.6 years. The numbers of the left anterior descending, left circumflex, and right coronary arteries were 130 (36.5%), 110 (30.9%), and 116 (32.6%), respectively. Using seven major features, the ML-FFR showed strong correlation (r = 0.8782, P < 0.001) with the wire-based FFR. The ML-FFR predicted wire-based FFR ≤ 0.80 in the test set with sensitivity of 98.3%, specificity of 61.5%, and overall accuracy of 91.7% (area under the curve: 0.948). External validation showed good correlation (r = 0.7884, P < 0.001) and accuracy of 83.2% (area under the curve: 0.912).

Conclusion

OCT-based ML-FFR showed good diagnostic performance in predicting FFR irrespective of the coronary territory. Because the study was a small-size study, the results should be warranted the performance in further large-scale research.
Case report: Mechanical-electric feedback and atrial fibrillation–Revelation from the treatment of a rare atrial fibrillation caused by annular constrictive pericarditis
Authors: Yi Dong , Li Lei , Han Min , Qiu Rujie , Tao Liang , Liu Li , Liu Chengwei
Published: January 2023

Atrial fibrillation (AF) is one of the most common arrhythmias encountered in clinical practice. The pathophysiological mechanisms responsible for its development are complex, vary amongst individuals, and associated with predisposing factors. Here, we report a case of AF caused by annular constrictive pericarditis (ACP), which is extremely rare due to its unusual anatomical form. In our patient, AF was refractory to multiple antiarrhythmic medications; however, spontaneous conversion to sinus rhythm occurred when the ring encircling the right and left ventricular (RV and LV) cavities along the atrioventricular (AV) groove was severed. This suggests that atrial stretch due to atrial enlargement and increased left atrial (LA) pressure may contribute to the initiation and maintenance of AF. This report highlights the importance of the careful investigation of rare predisposing factors for AF using non-invasive diagnostic approaches and mechanical-electric feedback (MEF) as a pathophysiological mechanism for AF initiation and maintenance.