bluuebunny/crossref_metadata_2025 huggingface dataset:
Ignition Delay Time Modeling in Wire-EDM
Authors: Borges Esteves Paulo Matheus , Hensen Micha , Kuffa Michal , Wegener Konrad
Published: October 2023

This study presents a comprehensive investigation and modeling of the ignition delay time (td) in wire-EDM (WEDM). The research focuses on the influence of gap distance, discharge energy, and piece height on the stochastic distributions of td, providing important insights into the complex properties of these distributions. Observations indicate that these parameters exert significant yet intricate influences on td, with a particular emphasis on the gap distance. A critical value was identified, around 8μm to 10μm, that divides the stochastic behavior. To capture the binomial nature of td, a mixture probability model consisting of two Weibull distribution curves was developed and validated through extensive experimentation and a data analysis. The model demonstrated strong agreement with observed cumulative probability curves, indicating its accuracy and reliability in predicting td. Further, a sensitivity analysis revealed regions of fast change, emphasizing the challenges and importance of careful parameter selection in control of WEDM processes. The findings of this study contribute to a deeper understanding of WEDM processes and provide a modeling approach for predicting td. Future research directions include refining the model by incorporating additional input parameters, investigating the influence of other process variables on td.
Impact Strength for 3D-Printed PA6 Polymer Composites under Temperature Changes
Authors: Díaz-Rodríguez Jorge Guillermo , Pertuz-Comas Alberto David , Bohórquez-Becerra Oscar Rodolfo
Published: October 2023

This paper shows how temperature influences impact energy for continuous fiber additively manufactured (AM) polymer matrix composites. AM composites were fabricated with a nylon-based matrix and four continuous reinforcements: fiberglass, high-temperature fiberglass (HSHT), Kevlar, and carbon. The tested temperatures ranged from −40 to 90 °C. The chosen printed configuration for the lattice structure and fiber volume was the configuration that was found to perform the best in the literature, with a volumetric fiber content of 24.2%. Impact tests showed that the best response was fiberglass, HSHT, Kevlar, and carbon, in that order. The impact resistance was lowered at temperatures below ambient temperatures and above 50 °C. Additionally, each material’s impact energy was adjusted to third-degree polynomials to model results, with correlation factors above 92%. Finally, the failure analysis showed the damage mechanisms of matrix cracking, delamination in the printing direction, fiber tearing, and fiber pulling as failure mechanisms.
Characterization and Modeling of Doppler Spectra for Offshore UHF-Band Sea Clutter at Low Grazing Angles
Authors: Zhao Peng , Wu Zhensen , Zhang Yushi , Zhang Jinpeng , Xu Xinyu , Wu Jiaji
Published: October 2023

The Doppler spectra of sea echoes, which contain abundant information on floating scatterers, are important for exploring the characteristics of sea clutter. Using sea clutter data at low grazing angles observed by a coherent ultra-high frequency (UHF) radar located on Lingshan Island in the Yellow Sea, China, this study conducted detailed research on the characteristics of Doppler spectra with multiple ocean parameters, including grazing angle, significant wave height (SWH), and wave directions. The effect of sea echoes with different local normalized intensities on short-time Doppler spectra was further studied. The results indicate that with increasing sea states, the bimodal behavior of Doppler spectra, an evident phenomenon of Bragg scattering, gradually weakens. The frequency shifts of the mean spectra increased linearly with increasing SWH and wind speed, decreased linearly with increasing grazing angle, and decreased with the cosine value of the relative wave direction angles. In comparison, frequency shifts of the short-time spectra increased with increasing sea states and local echo intensities but fluctuated around a fixed value after reaching a certain extent. For spectral widths, the grazing angle is a significant influencing factor, with its broadening trend evident with a decrease in the grazing angle, whereas other ocean parameters, such as wave direction and wind direction, have no apparent influence. Considering the major contributions of the parameters, semi-empirical models for the mean spectral frequency shifts, mean spectral widths and short-time spectral frequency shifts were proposed. By verifying the measured data and predicted results, the models exhibited good prediction accuracy and applicability. The proposed inferences and models are helpful for understanding low grazing angle UHF-band sea clutter characteristics and improving target detection algorithms in offshore areas. These findings supplement previous studies on sea clutter Doppler spectra.
Complex Plastids and the Evolution of the Marine Phytoplankton
Authors: Gruber Ansgar , Medlin Linda K.
Published: October 2023

Photosynthesis allows for the formation of biomass from inorganic carbon and therefore greatly enhances the amount of organic material on planet Earth. Especially, oxygenic photosynthesis removed a major bottleneck in the formation of biomass by utilising ubiquitous water (H2O) and CO2 molecules as raw materials for organic molecules. This, over billions of years, shaped the world into the form we know today, with an oxygen-containing atmosphere, largely oxygenated water bodies and landmasses consisting of sediment rocks. Oxygenic photosynthesis furthermore enabled the evolution of aerobic energy metabolism, and it would be very difficult to imagine animal (including human) life in the absence of molecular oxygen as an electron acceptor. Oxygenic photosynthesis first, and exclusively, evolved in cyanobacteria. However, eukaryotes also learned to photosynthesise, albeit with a trick, which is the integration of formerly free-living cyanobacteria into the eukaryotic cell. There, the former bacteria became endosymbionts, and from these endosymbionts, the photosynthetic organelles (termed plastids) evolved. In almost all major groups of eukaryotes, plastid-containing members are found. At the same time, plastid-related features also indicate that these plastids form a monophyletic group. This can be explained by the transfer of plastids between the eukaryotic super-groups, leading to plastids being found in groups that are otherwise non-photosynthetic. In this chapter, we discuss the evolutionary origin of plastids, with a special emphasis on the evolution of plankton algae, such as diatoms or dinoflagellates, who acquired their plastids from other photosynthetic eukaryotes.
Breast Cancer: Clinical–Epidemiological Profile and Toxicities of Women Receiving Treatment with Taxanes in the Amazon Region
Authors: Costa Marta Solange Camarinha Ramos , Fernandes Marianne Rodrigues , Pereira Esdras Edgar Batista , Leal Diana Feio da Veiga Borges , Coelho Rita de Cássia Calderaro , Menezes Elisa da Silva , Modesto Antônio André Conde , Assumpção Paulo Pimentel de , Burbano Rommel Mario Rodriguez , Santos Sidney Emanuel Batista dos , Santos Ney Pereira Carneiro dos
Published: October 2023

Breast cancer is the most common malignant disease and the leading cause of mortality among women worldwide. Antineoplastic chemotherapy is one of its primary treatments, typically based on the class of drugs known as taxanes. Despite their proven therapeutic efficacy, these drugs can induce severe toxicities, leading to dose limitations or even treatment discontinuation. The objective of this study was to describe the clinical–epidemiological profile, risk factors, and toxicities of taxane-based chemotherapy treatment in women with breast cancer in the Amazon region. This is a cross-sectional, quantitative, and descriptive study conducted with 300 women diagnosed with breast cancer undergoing taxane treatment. Most patients were in the 40–49 age range, of brown ethnicity, and had completed elementary school. The majority of patients had risk factors such as alcoholism and a sedentary lifestyles. Most women had their first pregnancy between the ages of 18 and 21, breastfed their children, had menarche between the ages of 12 and 13, and were pre-menopausal and with a family history of cancer. The most frequent histological type was non-special invasive carcinoma and the Luminal B subtype. Most participants in this study showed taxane toxicity, with neurotoxicity being the most frequent. These findings reveal the importance of early detection, comprehensive risk factors, and effective management of treatment toxicities to improve patient outcomes in breast cancer care in the Amazon region.
Novel Biomarkers and Their Role in the Diagnosis and Prognosis of Acute Coronary Syndrome
Authors: Katsioupa Maria , Kourampi Islam , Oikonomou Evangelos , Tsigkou Vasiliki , Theofilis Panagiotis , Charalambous Georgios , Marinos George , Gialamas Ioannis , Zisimos Konstantinos , Anastasiou Artemis , Katsianos Efstratios , Kalogeras Konstantinos , Katsarou Ourania , Vavuranakis Manolis , Siasos Gerasimos , Tousoulis Dimitris
Published: October 2023

The burden of cardiovascular diseases and the critical role of acute coronary syndrome (ACS) in their progression underscore the need for effective diagnostic and prognostic tools. Biomarkers have emerged as crucial instruments for ACS diagnosis, risk stratification, and prognosis assessment. Among these, high-sensitivity troponin (hs-cTn) has revolutionized ACS diagnosis due to its superior sensitivity and negative predictive value. However, challenges regarding specificity, standardization, and interpretation persist. Beyond troponins, various biomarkers reflecting myocardial injury, neurohormonal activation, inflammation, thrombosis, and other pathways are being explored to refine ACS management. This review article comprehensively explores the landscape of clinically used biomarkers intricately involved in the pathophysiology, diagnosis, and prognosis of ACS (i.e., troponins, creatine kinase MB (CK-MB), B-type natriuretic peptides (BNP), copeptin, C-reactive protein (CRP), interleukin-6 (IL-6), d-dimers, fibrinogen), especially focusing on the prognostic role of natriuretic peptides and of inflammatory indices. Research data on novel biomarkers (i.e., endocan, galectin, soluble suppression of tumorigenicity (sST2), microRNAs (miRNAs), soluble oxidized low-density lipoprotein receptor-1 (sLOX-1), F2 isoprostanes, and growth differentiation factor 15 (GDF-15)) are further analyzed, aiming to shed light on the multiplicity of pathophysiologic mechanisms implicated in the evolution of ACS. By elucidating the complex interplay of these biomarkers in ACS pathophysiology, diagnosis, and outcomes, this review aims to enhance our understanding of the evolving trajectory and advancements in ACS management. However, further research is necessary to establish the clinical utility and integration of these biomarkers into routine practice to improve patient outcomes.
Co-Effects of Nitrogen Fertilizer and Straw-Decomposing Microbial Inoculant on Decomposition and Transformation of Field Composted Wheat Straw
Authors: Shaghaleh Hiba , Zhu Yuanpeng , Shi Xinyi , Alhaj Hamoud Yousef , Ma Chao
Published: October 2023

Although straw is an abundant and useful agricultural byproduct, it, however, exhibits hardly any decomposition and transformation. Despite the successful application of chemical and biological substrates for accelerating straw decomposition, the co-effects and mechanisms involved are still unknown. Herein, we performed a 120 day field trial to examine the co-effects of a nitrogen fertilizer (N) and a straw-decomposing microbial inoculant (SDMI) on the straw mass, nutrient release, and the straw chemical structure of composted wheat straw in the Chaohu Lake area, East China. For this purpose, four treatments were selected with straw: S (straw only), NS (N + straw), MS (SDMI + straw), and NMS (N + SDMI + straw). Our results indicated that NMS caused a higher straw decomposition rate than S, NS, and MS (p < 0.05) after 120 days of composting. The N, P, and K discharge rates in treating with NMS were higher than other the treatments at 120 days. The A/OA ratios of the straw residues were gradually increased during the composting, but the treatment of NMS and MS was lower than the CK at the latter stage. The RDA showed that the decomposition rate, nutrient release, and the chemical structure change in the straw were cumulative, while respiration was strongly correlated with lignin peroxidase, manganese peroxidase, and neutral xylanase. In conclusion, nitrogen fertilizer or straw-decomposing microbial inoculant application can improve the decomposition rate and nutrient release with oxidase activity intensified. However, the co-application of nitrogen fertilizer and a straw-decomposing microbial inoculant promoted straw decomposition and enzyme activity better than a single application and showed a lower decomposition degree, which means more potential for further decomposing after 120 days.
Meckel’s Diverticulum Causing Ileal Volvulus and Peritonitis after a Recent Appendectomy: A Case Report and Literature Review—We Should Likely Resect an Incidental MD
Authors: Zanchetta Matteo , Inversini Davide , Pappalardo Vincenzo , Grappolini Niccolo , Morabito Marika , Gianazza Simone , Carcano Giulio , Ietto Giuseppe
Published: October 2023

Meckel’s diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract with a 1–3% prevalence in the general population. The surgical management of symptomatic MD is well described in the literature, but there is still no consensus on the indication for prophylactic resection of incidental asymptomatic MD. To address this issue, we extensively reviewed the current literature and report our experience with laparoscopic management of an unusual case of MD causing ileal volvulus and acute peritonitis two weeks after a laparoscopic appendectomy for acute gangrenous appendicitis performed in another hospital. A 50-year-old man presented to the emergency department with acute and severe abdominal pain, vomiting, and constipation. He had undergone a laparoscopic appendectomy for acute appendicitis two weeks before in another hospital. The patient was apyretic, distressed, and seeking an antalgic position. The abdomen was mildly distended and tender, and the Blumberg sign was mildly positive in the central quadrants. The clinical picture deteriorated with fever, peritonismus, and leukocytosis. A CT scan showed an ileo–ileal adhesion near the ileocolic junction and dilatation of the upstream loops with the air–fluid levels. Through an urgent laparoscopy, a necrotic mass, the MD, was wedge-resected, and the surrounding ileal volvulus derotated. The postoperative course was uneventful. There is no definitive consensus on the appropriate management of incidental asymptomatic MD, although several studies have attempted to identify guiding criteria. Features of the MD, the patient’s risk factors, clinical presentation, and surgical approach need to be considered to establish definitive guidelines for the management of incidental asymptomatic MD. In the absence of definitive guidelines, personal expertise and judgement are the main resources for the surgeon approaching an incidental asymptomatic MD.
Preliminary Assessment of the Acute Effects of Far Infrared-Emitting Garments: What Are the Possible Implications for Recovery and Performance?
Authors: Bertuccioli Alexander , Cannataro Roberto , Gervasi Marco , Benelli Piero , Gregoretti Aurora , Ragazzini Mirko , Neri Marco , Palazzi Chiara Maria , Cardinali Marco , Zonzini Giordano
Published: October 2023

Technical clothing has recently been brought into the spotlight as one of the most promising tools to improve sports performance and to enhance sports recovery. Among technical clothing items, garments engineered to emit far infrared (FIR) spectrum frequencies have come to the fore as a treatment for pain, muscle fatigue, and tissue healing due to their potential antioxidative and anti-inflammatory properties, with applications not only during recovery phases but also in the active phases of exercise. These garments, composed of fibers mixed with noble metals and/or bioceramics that respond to body infrared frequencies by returning an FIR emission backwards, are thought to improve muscle oxygenation and therefore recovery. In this double-blind, randomized, placebo-controlled, crossover study, ten male trail running athletes wore a whole-body-covering suit marketed as Accapì-FIR (Bruno Chiaruttini S.r.l., Rezzato, BS, Italy), while a total body suit with the same polyester fiber without metal components was used as control for the intervention. Parameters such as weight, height, bioimpedance parameters (BIVA), lactate from capillary sampling, salivary cortisol, and average temperatures of different body areas were obtained before and after a twelve-minute incremental work run protocol on a treadmill whilst wearing the two kinds of garment. Using the intervention suit, compared to control, statistically significant reductions in BIVA parameters such as body resistance (−6.7%) and reactance (−5.4%) were observed before and after exercise while a greater, but not significant, weight reduction was observed with the intervention suit. Decrease in resistance could be the result of a different distribution of fluids and ions due to FIR influence on capillary and superficial circulation, leading ultimately to more efficient management of body heat and promoting recovery and supercompensation. Further studies on larger samples will be necessary to confirm and clarify these results.
Development of Sensitive Methods for the Detection of Minimum Concentrations of DNA on Martian Soil Simulants
Authors: Li Yongda , Rochfort Keith D. , Collins David , Grintzalis Konstantinos
Published: October 2023

Several methods used for the quantification of DNA are based on UV absorbance or the fluorescence of complexes with intercalator dyes. Most of these intercalators are used in gels to visualize DNA and its structural integrity. Due to many extraterrestrial samples, such as meteorites or comets, which are likely to contain very small amounts of biological material, and because the ability to detect this material is crucial for understanding the origin and evolution of life in the universe, the development of assays that can detect DNA at low limits and withstand the rigors of space exploration is a pressing need in the field of astrobiology. In this study, we present a comparison of optimized protocols used for the fast and accurate quantification of DNA using common intercalator dyes. The sensitivity of assays exceeded that generated by any commercial kit and allowed for the accurate quantification of minimum concentrations of DNA. The methods were successful when applied to the detection and measurement of DNA spiked on soil samples. Furthermore, the impact of UV radiation as a harsh condition on the surface of Mars was assessed by DNA degradation and this was also confirmed by gel electrophoresis. Overall, the methods described provide economical, simple-step, and efficient approaches for the detection of DNA and can be used in future planetary exploration missions as tests used for the extraction of nucleic acid biosignatures.
Leber’s Hereditary Optic Neuropathy (LHON): Clinical Experience and Outcomes after Long-Term Idebenone Treatment
Authors: Baltă George , Cristache Georgiana , Barac Andreea Diana , Anton Nicoleta , Barac Ileana Ramona
Published: October 2023

Background: Leber’s hereditary optic neuropathy (LHON) is a rare disease. Large studies are difficult to conduct; therefore, case reports provide valuable data. Since 2015, patients have been treated with Idebenone. The aim of this paper is to share our experience with diagnosing and managing patients in different stages of LHON. Methods: We designed a case series study, including four patients undergoing genetic testing and ophthalmologic examination. Criteria for Idebenone administration and follow-up were presented. Results: All patients had mutation 11778G>A in MT-ND4. The first patient, an 82-year-old man, with long history of vision loss, had no indication for Idebenone. Two additional cases emerged within the same family: a 40-year-old brother and a 31-year-old sister. Both received Idebenone, with good outcomes only for the female. After a one-year regimen, they were lost to follow-up. The fourth patient, a 46-year-old man, was diagnosed in the subacute stage. Idebenone administration was deferred, allowing progression of visual field defects. After 17 months of treatment, visual improvement appeared. The treatment was continued for 36 months, with short interruptions, resulting in good outcomes. Conclusions: Our study demonstrated positive results with long-term Idebenone use. Contrary to medical literature, our female patient had a favorable evolution, despite the delayed diagnosis.
Optical and Clinical Outcomes of an Isofocal Intraocular Lens vs. a Monofocal Standard Lens
Authors: Pérez-Sanz Lidia , Gonzalez-Fernandez Veronica , Gómez-Pedrero José Antonio , Albarrán-Diego César , García-Montero María , Garzón Nuria
Published: October 2023

The aim of this study is to evaluate the results obtained on the optical bench and clinically with an isofocal lens (ISOPure, BVI medical, Belgium) to compare them to a standard monofocal one (MicroPure, BVI medical, Belgium). To do so, we have combined laboratory investigation and a prospective, comparative, and randomized clinical study. First, we have measured the wavefront of the two models studied using a NIMO TR1504 (Lambda-X, Belgium) deflectometer for three nominal powers: +10.00, +20.00 and +30.00 D. In the randomized study with 48 patients, half of them implanted with ISOPure and the other with MicroPure, we have measured visual acuities and contrast sensitivity under photopic and mesopic conditions. The optical bench results show that the isofocal lens presented higher power than the monofocal one, at the lens center, due to the spherical aberration (coefficients Z(4,0), Z(6,0) and Z(8,0)) induced by the greater asphericity of its design. The addition obtained depended on the nominal power, from +1.00 to +1.50 D. The results of the clinical study showed that the ISOPure lens presented better visual outcomes, which were statistically significant, at intermediate distance compared to the MicroPure lens (p-values of 0.014 and 0.022 for 80 and 60 cm, respectively) without decreasing the contrast sensitivity. Clinical outcomes were not affected by pupillary size. In conclusion, due to the increase in power at the lens center due to its highly aspherical design, the isofocal lens evaluated showed better intermediate vision than the monofocal one.
Groups of Symmetries of the Two Classes of Synthetases in the Four-Dimensional Hypercubes of the Extended Code Type II
Authors: José Marco V. , Morgado Eberto R. , Bobadilla Juan R.
Published: October 2023

Aminoacyl-tRNA synthetases (aaRSs) originated from an ancestral bidirectional gene (mirror symmetry), and through the evolution of the genetic code, the twenty aaRSs exhibit a symmetrical distribution in a 6-dimensional hypercube of the Standard Genetic Code. In this work, we assume a primeval RNY code and the Extended Genetic RNA code type II, which includes codons of the types YNY, YNR, and RNR. Each of the four subsets of codons can be represented in a 4-dimensional hypercube. Altogether, these 4 subcodes constitute the 6-dimensional representation of the SGC. We identify the aaRSs symmetry groups in each of these hypercubes. We show that each of the four hypercubes contains the following sets of symmetries for the two known Classes of synthetases: RNY: dihedral group of order 4; YNY: binary group; YNR: amplified octahedral group; and RNR: binary group. We demonstrate that for each hypercube, the group of symmetries in Class 1 is the same as the group of symmetries in Class 2. The biological implications of these findings are discussed.
Design and Numerical Study of Magnetic Energy Storage in Toroidal Superconducting Magnets Made of YBCO and BSCCO
Authors: Jubleanu Radu , Cazacu Dumitru
Published: October 2023

The superconducting magnet energy storage (SMES) has become an increasingly popular device with the development of renewable energy sources. The power fluctuations they produce in energy systems must be compensated with the help of storage devices. A toroidal SMES magnet with large capacity is a tendency for storage energy because it has great energy density and low stray field. A key component in the creation of these superconducting magnets is the material from which they are made. The present work describes a comparative numerical analysis with finite element method, of energy storage in a toroidal modular superconducting coil using two types of superconducting material with different properties bismuth strontium calcium copper oxide (BSCCO) and yttrium barium copper oxide (YBCO). Regarding the design of the modular torus, it was obtained that for a 1.25 times increase of the critical current for the BSCCO superconducting material compared with YBCO, the dimensions of the BSCCO torus were reduced by 7% considering the same stored energy. Also, following a numerical parametric analysis, it resulted that, in order to maximize the amount of energy stored, the thickness of the torus modules must be as small as possible, without exceeding the critical current. Another numerical analysis showed that the energy stored is maximum when the major radius of the torus is minimum, i.e., for a torus as compact as possible.
The RANK–RANKL–OPG System: A Multifaceted Regulator of Homeostasis, Immunity, and Cancer
Authors: De Leon-Oliva Diego , Barrena-Blázquez Silvestra , Jiménez-Álvarez Laura , Fraile-Martinez Oscar , García-Montero Cielo , López-González Laura , Torres-Carranza Diego , García-Puente Luis M. , Carranza Sara T. , Álvarez-Mon Miguel Ángel , Álvarez-Mon Melchor , Diaz Raul , Ortega Miguel A.
Published: October 2023

The RANK–RANKL–OPG system is a complex signaling pathway that plays a critical role in bone metabolism, mammary epithelial cell development, immune function, and cancer. RANKL is a ligand that binds to RANK, a receptor expressed on osteoclasts, dendritic cells, T cells, and other cells. RANKL signaling promotes osteoclast differentiation and activation, which leads to bone resorption. OPG is a decoy receptor that binds to RANKL and inhibits its signaling. In cancer cells, RANKL expression is often increased, which can lead to increased bone resorption and the development of bone metastases. RANKL-neutralizing antibodies, such as denosumab, have been shown to be effective in the treatment of skeletal-related events, including osteoporosis or bone metastases, and cancer. This review will provide a comprehensive overview of the functions of the RANK–RANKL–OPG system in bone metabolism, mammary epithelial cells, immune function, and cancer, together with the potential therapeutic implications of the RANK–RANKL pathway for cancer management.
Common Skin Diseases and Their Psychosocial Impact among Jazan Population, Saudi Arabia: A Cross-Sectional Survey during 2023
Authors: Mahfouz Mohamed Salih , Alqassim Ahmad Y. , Hakami Fanan Adel , Alhazmi Abrar Khalid , Ashiri Amjad Mohammed , Hakami Alaa Marwei , Khormi Linan Mohammed , Adawi Yara Mohammed , Jabrah Asmaa Ahmed
Published: October 2023

Background and Objectives: Skin problems are a widespread issue that affects people in both developing and wealthy countries, posing significant public health concerns. These disorders can profoundly impact individuals’ social and psychological well-being. In this study, we aimed to determine the prevalence of the most common skin diseases in the Jazan region of southwestern Saudi Arabia and investigate their impact on patients’ quality of life and psychological and social well-being. Materials and Methods: An observational cross-sectional survey conducted among a random sample of 940 adults ≥ 18 years in the Jazan region, Saudi Arabia. Four standardized questionnaires were used for data collection: Patient Health Questionnaire (PHQ-9), a five-dimension questionnaire (EQ-5D), Rosenberg Self-Esteem Scale, and Loneliness Scale (ULS-8). Results: The most prevalent skin conditions involved hair loss, which was reported by (61.1%) of the study population. These disorders significantly affected a higher percentage of females (71.9%) compared to males (46.3%) (p < 0.001). Melasma was more common in females (14.1%) than in males (4.3%) p < 0.001. The lowest prevalence was found for urticaria. Those with acne and hair loss reported higher mean scores on the PHQ-9 Scale than the group without these conditions (p < 0.05 for all). Patients with alopecia, acne, and melasma also reported significantly lower self-esteem scores compared to those without these skin conditions (p < 0.05 for all). Regarding the activity domain of QoL, participants with skin conditions reported no problems doing usual activities, compared to those without skin problems (p < 0.001). Conclusions: In conclusion, research revealed that the most prevalent skin condition was hair loss. Further, an association was found between skin diseases and the mental and social well-being of those affected, resulting in a negative impact on their quality of life. The results call for improving the condition of patients with skin diseases, improving their quality of life, and providing appropriate interventions.
Cognitive Impairment in Parkinson’s Disease: An Updated Overview Focusing on Emerging Pharmaceutical Treatment Approaches
Authors: Degirmenci Yildiz , Angelopoulou Efthalia , Georgakopoulou Vasiliki Epameinondas , Bougea Anastasia
Published: October 2023

Cognitive impairment in patients with Parkinson’s disease (PD) is one of the commonest and most disabling non-motor manifestations during the course of the disease. The clinical spectrum of PD-related cognitive impairment includes subjective cognitive decline (SCD), mild cognitive impairment (MCI) and PD dementia (PDD). As the disease progresses, cognitive decline creates a significant burden for the family members and/or caregivers of patients with PD, and has a great impact on quality of life. Current pharmacological treatments have demonstrated partial efficacy and failed to halt disease progression, and novel, effective, and safe therapeutic strategies are required. Accumulating preclinical and clinical evidence shows that several agents may provide beneficial effects on patients with PD and cognitive impairment, including ceftriaxone, ambroxol, intranasal insulin, nilotinib, atomoxetine, mevidalen, blarcamesine, prasinezumab, SYN120, ENT-01, NYX-458, GRF6021, fosgonimeton, INT-777, Neuropeptide S, silibinin, osmotin, cordycepin, huperzine A, fibroblast growth factor 21, Poloxamer 188, ginsenoside Rb1, thioredoxin-1, tangeretin, istradefylline and Eugenia uniflora. Potential underlying mechanisms include the inhibition of a-synuclein aggregation, the improvement of mitochondrial function, the regulation of synaptic plasticity, an impact on the gut–brain axis, the modulation of neuroinflammation and the upregulation of neurotrophic factors, as well as cholinergic, dopaminergic, serotoninergic and norepinephrine neurotransmission. In this updated overview, we aim to cover the clinical aspects of the spectrum of PD-related cognitive impairment and discuss recent evidence on emerging treatment approaches that are under investigation at a preclinical and clinical level. Finally, we aim to provide additional insights and propose new ideas for investigation that may be feasible and effective for the spectrum of PD-related cognitive impairment.
Therapeutic Challenges for Gastric Neuroendocrine Neoplasms: Take It or Leave It?
Authors: Cavalcoli Federica , Gallo Camilla , Coltro Lorenzo Andrea , Rausa Emanuele , Cantù Paolo , Invernizzi Pietro , Massironi Sara
Published: October 2023

Background and Objectives: Gastric neuroendocrine neoplasms (gNENs) represent rare but increasingly recognized tumors. They are distinguished into three main clinical types (type-1, type-2, and type-3) according to gastrin level and at histological evaluation in well-differentiated G1, G2, or G3 lesions, as well as poorly-differentiated lesions. Small type-1 and type-2 neoplasms with low proliferation indices demonstrated excellent survival without progression during an extended follow-up period, and for these reasons, active endoscopic observation or endoscopic resection are feasible options. On the other hand, surgery is the treatment of choice for more aggressive type-3, G3, or infiltrating neoplasms. The present study aims to comprehensively review and compare the available therapeutic strategies for gNENs. Materials and Methods: A computerized literature search was performed using relevant keywords to identify all of the pertinent articles with particular attention to gNEN endoscopic treatment. Results: In recent years, different endoscopic resective techniques (such as endoscopic mucosal dissection, modified endoscopic mucosal resection, and endoscopic full-thickness resection) have been developed, showing a high rate of complete resection for advanced and more aggressive lesions. Conclusions: Overall, gNENs represent a heterogeneous group of lesions with varying behavior which require personalized management. The non-operative approach for small type-1 gNENs seems to be feasible and should be promoted. A step-up approach with minimally invasive endoscopic therapies might be proposed, particularly for type-1 gNEN. On the other hand, it is important to recognize the negative prognostic factors in order to identify those rare cases requiring more aggressive approaches. A possible therapeutic algorithm for localized gNEN management is provided.
Prediction of Isotropic Rough Surface Directional Spectral Emissivity with Surface-Morphology-Dependent Modelling
Authors: Hu Jianrui , Liu Zhanqiang , Zhao Jinfu , Wang Bing
Published: October 2023

The surface directional spectral emissivity of rough metal surfaces in industry is of concern in infrared temperature measurement. In this research, the height and slope possibility density functions are introduced as variables, and the directional spectral emissivity of isotropic rough surface is modelled accordingly. The model is designed to derive the directional spectral emissivity of rough metal surfaces from the surface morphology (possibility distribution of the height and slope) and the material property parameters (refractivity). Then, a sandblasted surface is taken as a case study. The sandblasted surface morphology is measured. A Polynomial surface is proposed to describe the sandblasted surface morphology and is compared with a Gaussian surface and a Cox–Munk surface. Finally, the directional spectral emissivity measurement and infrared temperature measurement are conducted. It is shown that the predicted directional spectral emissivity and measured temperature with the surface-morphology-dependent isotropic rough surface directional spectral emissivity model have high precision. In this work, the possibility distribution of the height and slope of the surface is introduced as independent variables to provide better accuracy compared to the reported models. In some cases, the error of the infrared temperature measurement could be reduced to 20% (80 degrees, compared to Gaussian surface). This work contributes to improving the accuracy of IR temperature measurement of rough surfaces.
In Situ Prediction of Metal Fatigue Life Using Frequency Change
Authors: Mahmoudi Ali , Amooie Mohammad A. , Koottaparambil Lijesh , Khonsari Michael M.
Published: October 2023

A reliable technique for rapid prediction of the remaining useful life (RUL) of components experiencing fatigue degradation is introduced. The approach is based on measuring the temperature signature of a component upon rapidly changing its operating frequency for a short period of time. The temperature variations caused by alterations in plastic work rate are correlated to the loading history. The efficacy of the approach is investigated by conducting a series of axial fatigue tests on stainless steel 316 specimens. The material characterization involves subjecting the material to a constant amplitude fatigue load at 4 Hz and 12 Hz frequencies. The operating frequency is temporarily adjusted to the characterization frequencies for a brief duration. During this period, the change in the slope of temperature rise is recorded. Subsequently, the operation frequency is reverted to its original state, and the remaining useful life is predicted based on the recorded data. The model provides predictions for operation frequencies of 6 Hz, 8 Hz, and 12 Hz, and notably, the error of predictions is consistently under 12% for all cases. The method allows the operator to reliably estimate the remaining usefulness for field applications without interrupting the operation.
Temperature Gradient and Solidification Rate Simulation Model of the Microstructure of Laser-Cladded 27SiMn
Authors: Ma Kun , Cheng Yanhai , Jeyaprakash Natarajan , Zhou Jiali , Wan Yixing , Yang Wenhui
Published: October 2023

In this study, 27SiMn was selected as a substrate, and the powder was a self-made iron-based alloy. Further, the thermophysical properties of the material were predicted by the CALPHAD phase diagram algorithm. In order to verify the accuracy of the numerical model, 10 sets of experiments were set up. The agreement between the results from the model calculations and the experimental results was 92%. Through the study of energy distribution in the laser cladding process, it was found that about 10% of the laser energy was used to heat the substrate to form a melt pool, and at least 53% of the energy was radiated into the environment. Finally, the effects of the temperature gradient and solidification rate on the microstructure of the cladding layer were explored. The numerical simulation results are helpful in predicting the solidification rate, temperature distribution and microstructure of the melt pool, thereby reducing the cost of testing as well as the time for the experimental method of trial–error.
Ultra-Performance Liquid Chromatography Coupled with Mass Metabolic Profiling of Ammi majus Roots as Waste Product with Isolation and Assessment of Oral Mucosal Toxicity of Its Psoralen Component Xanthotoxin
Authors: Fathallah Noha , El Deeb Mona , Rabea Amany A. , Almehmady Alshaimaa M. , Alkharobi Hanaa , Elhady Sameh S. , Khalil Noha
Published: October 2023

Ammi majus, a well-established member of the Umbelliferae (Apiaceae) family, is endogenous to Egypt. The main parts of this plant that are used are the fruits, which contain coumarins and flavonoids as major active constituents. The roots are usually considered by-products that are discarded and not fed to cattle because of coumarins’ potential toxicity. The goal of this study was to ensure the sustainability of the plant, investigate the active metabolites present in the roots using UPLC/MS-MS, isolate and elucidate the major coumarin Xanthotoxin, and predict its oral bioavailability and its potential biological impact on tongue papillae. The results revealed coumarins as the dominant chemical class in a positive acquisition mode, with bergaptol-O-hexoside 5%, Xanthotoxin 5.5%, and isoarnoittinin 6% being the major compounds. However, phenolics ruled in the negative mode, with p-coumaroyl tartaric acid 7%, 3,7-dimethyl quercetin 6%, and hesperidin 5% being the most prominent metabolites. Fractionation and purification of the chloroform fraction yielded Xanthotoxin as one of the main compounds, which appeared as white needle crystals (20 mg). ADME studies for oral bioavailability were performed to predict the potential properties of the compound if used orally. It was noted that it followed Lipinski’s rule of five, had just one parameter outside of the pink area in the radar plot, and was detected inside the threshold area using the boiled egg approach. In vivo, histopathological studies performed on rats showed a notable decrease in the tongue’s keratin thickness from an average of 51.1 µm to 9.1 µm and an average of 51.8 µm to 9.8 µm in fungiform and filiform cells, respectively. The results indicated that although Xanthotoxin is a well-known medical agent with several potential therapeutic activities in oral therapy, it may cause a destructive effect on the structure of the specialized mucosa of the tongue.
The Effect of Organic and Conventional Cultivation Systems on the Profile of Volatile Organic Compounds in Winter Wheat Grain, Including Susceptibility to Fusarium Head Blight
Authors: Buśko Maciej , Gracka Anna , Jeleń Henryk , Szablewska Kinga Stuper , Przybylska-Balcerek Anna , Szwajkowska-Michałek Lidia , Góral Tomasz
Published: October 2023

The grain of 30 winter wheat cultivars differing in terms of their resistance to FHB (Fusarium head blight) was tested. The cultivars were grown in four variants of field trials established in a split-plot design: control without fungicides, chemical control of FHB with fungicides after Fusarium inoculation, Fusarium head inoculation, and organic cultivation. The profile of volatile compounds in grain samples was determined by mean headspace–solid phase microextraction and analyzed by gas chromatography time-of-flight mass spectroscopy. The identified volatile profile comprised 146 compounds belonging to 14 chemical groups. The lowest abundance of volatile organic compounds (VOCs) was found for the organic cultivation variant. The performed discriminant analysis facilitated the complete separation of grain for individual experimental variants based on the number of VOCs decreasing from 116 through 62, 37 down to 14. The grain from organic farming was characterized by a significantly different VOCs profile than the grain from the other variants of the experiment. The compounds 1-methylcycloheptanol, 2-heptanone, 2(3H)-furanone, and 5-hexyldihydro-2(3H)-furanone showed statistically significant differences between all four experimental variants.
Insights on the Organ-Dependent, Molecular Sexual Dimorphism in the Zebra Mussel, Dreissena polymorpha, Revealed by Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry Metabolomics
Authors: Lance Emilie , Sartor Lucas , Foucault Pierre , Geffard Alain , Marie Benjamin
Published: October 2023

The zebra mussel, Dreissena polymorpha, is extensively used as a sentinel species for biosurveys of environmental contaminants in freshwater ecosystems and for ecotoxicological studies. However, its metabolome remains poorly understood, particularly in light of the potential molecular sexual dimorphism between its different tissues. From an ecotoxicological point of view, inter-sex and inter-organ differences in the metabolome suggest variability in responsiveness, which can influence the analysis and interpretation of data, particularly in the case where males and females would be analyzed indifferently. This study aimed to assess the extent to which the molecular fingerprints of functionally diverse tissues like the digestive glands, gonads, gills, and mantle of D. polymorpha can reveal tissue-specific molecular sexual dimorphism. We employed a non-targeted metabolomic approach using liquid chromatography high-resolution mass spectrometry and revealed a significant sexual molecular dimorphism in the gonads, and to a lesser extent in the digestive glands, of D. polymorpha. Our results highlight the critical need to consider inter-sex differences in the metabolome of D. polymorpha to avoid confounding factors, particularly when investigating environmental effects on molecular regulation in the gonads, and to a lesser extent in the digestive glands.
Modeling of Magnetoelectric Microresonator Using Numerical Method and Simulated Annealing Algorithm
Authors: Sadeghi Mohammad , Bazrafkan Mohammad M. , Rutner Marcus , Faupel Franz
Published: October 2023

A comprehensive understanding of the linear/nonlinear dynamic behavior of wireless microresonators is essential for micro-electromechanical systems (MEMS) design optimization. This study investigates the dynamic behaviour of a magnetoelectric (ME) microresonator, using a finite element method (FEM) and machine learning algorithm. First, the linear/nonlinear behaviour of a fabricated thin-film ME microactuator is assessed in both the time domain and frequency spectrum. Next, a data driven system identification (DDSI) procedure and simulated annealing (SA) method are implemented to reconstruct differential equations from measured datasets. The Duffing equation is employed to replicate the dynamic behavior of the ME microactuator. The Duffing coefficients such as mass, stiffness, damping, force amplitude, and excitation frequency are considered as input parameters. Meanwhile, the microactuator displacement is taken as the output parameter, which is measured experimentally via a laser Doppler vibrometer (LDV) device. To determine the optimal range and step size for input parameters, the sensitivity analysis is conducted using Latin hypercube sampling (LHS). The peak index matching (PIM) and correlation coefficient (CC) are considered assessment criteria for the objective function. The data-driven developed models are subsequently employed to reconstruct/predict mode shapes and the vibration amplitude over the time domain. The effect of driving signal nonlinearity and total harmonic distortion (THD) is explored experimentally under resonance and sub-resonance conditions. The vibration measurements reveal that as excitation levels increase, hysteresis variations become more noticeable, which may result in a higher prediction error in the Duffing array model. The verification test indicates that the first bending mode reconstructs reasonably with a prediction accuracy of about 92 percent. This proof-of-concept study demonstrates that the simulated annealing approach is a promising tool for modeling the dynamic behavior of MEMS systems, making it a strong candidate for real-world applications.
Effects of Oxygen Pressure on the Microstructures and Nanomechanical Properties of Samarium-Doped BiFeO3 Thin Films
Authors: Gao Chih-Sheng , Jian Sheng-Rui , Le Phuoc Huu , Chou Wu-Ching , Juang Jenh-Yih , Chang Huang-Wei , Lin Chih-Ming
Published: October 2023

In this study, samarium (Sm-10at%)-doped BiFeO3 (SmBFO) thin films were grown on platinum-coated glass substrates using pulsed laser deposition (PLD) to unveil the correlation between the microstructures and nanomechanical properties of the films. The PLD-derived SmBFO thin films were prepared under various oxygen partial pressures (PO2) of 10, 30, and 50 mTorr at a substrate temperature of 600 °C. The scanning electron microscopy analyses revealed a surface morphology consisting of densely packed grains, although the size distribution varied with the PO2. X-ray diffraction results indicate that all SmBFO thin films are textured and preferentially oriented along the (110) crystallographic orientation. The crystallite sizes of the obtained SmBFO thin films calculated from the Scherrer and (Williamson–Hall) equations increased from 20 (33) nm to 25 (52) nm with increasing PO2. In addition, the nanomechanical properties (the hardness and Young’s modulus) of the SmBFO thin films were measured by using nanoindentation. The relationship between the hardness and crystalline size of SmBFO thin films appears to closely follow the Hall–Petch equation. In addition, the PO2 dependence of the film microstructure, the crystallite size, the hardness, and Young’s modulus of SmBFO thin films are discussed.