bluuebunny/crossref_metadata_2025 huggingface dataset:
Motherwort (Leonurus japonicus Houtt.) extends the lifespan and healthspan of Caenorhabditis elegans via sir-2.1 and daf-16 activation
Authors: Yang Wooin , Yoon Young Jin , Jeon Yong Deok , Lee Se Youn , Jeon Hoon , Cha Dong Seok
Published: November 2023

Introduction: As a traditional medicine, the aerial parts of Leonurus japonicus Houtt. (Lamiaceae), aka motherwort, have been extensively used to treat gynecological diseases. The current study was designed to investigate the longevity properties of the methanolic extract of L. japonicus (MLJ) using Caenorhabditis elegans model system. Methods: The longevity effect of MLJ was determined by lifespan assay. Lipofuscin accumulation, thermotolerance, and body movement were measured to test the effects on the healthspan. The antioxidant capacity of MLJ was investigated by analyzing antioxidant enzyme activities, intracellular reactive oxygen species (ROS) levels, and the survival rate against oxidative stress conditions. Pharyngeal pumping rate and body length were observed to determine the effect of MLJ on aging-related factors. Transcriptional activity of daf-16 was observed under fluorescence microscopy using a transgenic mutant carrying DAF-16::GFP transgene. Results: MLJ could significantly prolong the median and maximum lifespan of worms. In addition, MLJ reduced the accumulation of lipofuscin in aged worms and delayed the age-dependent decrease in locomotion and thermotolerance suggesting its beneficial role in the healthspan. Also, MLJ increased the stress resistance of worms against oxidative stress and decreased intracellular ROS generation by up-regulating the activities of antioxidant enzymes. Additional genetic studies showed that MLJ failed to prolong the lifespan of worms lacking daf-2, age-1, daf-16, and sir-2.1 genes. Moreover, in the presence of MLJ, the nuclear translocation of daf-16 was significantly increased. Conclusion: Collectively, our results demonstrate that the anti-aging properties of MLJ might be attributed to sir-2.1 and insulin/IGF signaling-dependent daf-16/FOXO activation.
Ameliorative effects of phlorotannin-rich fraction of Sargassum tenerrimum in high-fat diet and low dose streptozotocin-induced metabolic changes and oxidative stress in diabetic rats
Authors: Godlaveti Vijay Narasimha Kumar , Vellapandian Chitra
Published: November 2023

Introduction: Type 2 diabetes mellitus (T2D) is a progressing polygenic disease demanding a multitargeted treatment strategy. Sargassum tenerrimum (ST) is a marine brown alga with potentially bioactive chemicals that could be used as innovative biotherapeutics for diabetes treatment. The current research examined the potential of the phlorotannin-rich fraction from S. tenerrimum (PST) to mitigate diabetes in Wistar albino rats induced with high-fat diet (HFD) and streptozotocin (STZ) administration. Methods: Diabetic rats were given PST (200 and 400 mg/kg) or metformin (250 mg/kg) orally three weeks, and followed by the measurements of insulin, glycemic factors, biological markers of oxidative stress, tumor necrosis factor-alpha (TNF-α), as well as hepatic and pancreatic histopathological changes. Results: PST treatment significantly decreased fasting blood glucose, insulin resistance, lipid profile, hepatic profile, and TNF- α levels and improved serum insulin and glucose tolerance in diabetic rats. In the skeletal muscles of diabetic rats, PST led to a significant rise in antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) reductase, and a decrease in lipid peroxidation. Furthermore, PST treatment significantly reduced pancreatic-cell damage and hepatic fatty accumulation. PST was more efficacious at 400 mg/kg exhibiting a dose-dependent effect. Conclusion: PST improves glucolipid metabolism in HFD and STZ-induced diabetic rats, probably by reducing hyperglycemia, insulin resistance, dyslipidemia, oxidative stress, inflammation, and damage to pancreatic and hepatic architectures. The findings suggest that PST has a curative impact on diabetes mellitus type 2 and represents a new subject of study for the treatment of diabetes naturally.
Biogenic synthesis, characterization, antibacterial and antioxidant activities of silver nanoparticles mediated from Tamarindus indica Linn fruit pulp extract
Authors: Fagbemi Kehinde Oluwakemi , Olajuyigbe Olufunmiso Olusola , Coopoosamy Roger
Published: November 2023

Introduction: Due to the numerous potentials discovered from biologically synthesized silver nanoparticles (SNPs), the interest of many researchers has been stirred up. Tamarindus indica fruit has many therapeutic potentials attributed to fruit. Hence, the objective of this study was to synthesize, characterize, and evaluate the in vitro antioxidant and antibacterial activities of SNPs mediated from T. indica fruit pulp extract. Methods: The bioreduction of silver nitrate was performed using methanol extract of T. indica fruit pulp. UV–vis spectrophotometry studies at 480 nm confirmed the synthesis of SNPs. The synthesized nanoparticles were characterized using Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDX). The antioxidant properties were assessed using methods of ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The antibacterial potential was evaluated using the agar well technique. Results: FTIR spectroscopy revealed that the presence of various functional groups was responsible for reduction and stabilization during the biosynthesis process. With the aid of ImageJ software, the size of the nanoparticles was determined to be in the range of 18-50 nm. The anti-oxidation activity assays showed a strong reducing potential towards the radicals tested. Lastly, strong antibacterial activities were observed when the nanoparticles were tested on some pathogenic bacteria through the agar well method. Conclusion: This biological method of synthesizing SNP from T. indica has shown significant enhancement in its biological activities in terms of antibacterial and antioxidant properties; thus, it might be considered a therapeutic agent.
Anti-inflammatory and antioxidant properties of Sargassum polycystum ethyl acetate extract from Indonesia
Authors: Sianipar Erlia Anggrainy , Gunardi Shannen Ivanka
Published: November 2023

Introduction: Inflammatory diseases, including asthma, osteoarthritis, rheumatoid arthritis, and cancer persist with relatively high incidence, which highlights the need to explore natural alternatives such as the bioactive substances of brown algae (Sargassum polycystum). Certain substances, such as phenolics and flavonoids, have been demonstrated to have an association with antioxidant activity because of their capacity to fend off free radicals, which cause inflammation. The purpose of this study was to look into the inflammatory inhibition and antioxidant activity of an ethyl acetate extract of S. polycystum from Indonesia. Methods: After maceration in ethyl acetate (1:4 w/v) for 24 hours, the total phenolic and flavonoid content of S. polycystum extract was measured using the colorimetric method. The antioxidant activity was tested using 1,1-diphenyl-2-picrylhydrazyl (DPPH), and the models of paw edema induced by carrageenan were used to assess inflammatory inhibition activity. Results: The findings revealed that S. polycystum had a weak antioxidant with a half-maximal inhibitory concentration (IC50) value of 605.24 ± 26.53 g/mL. Furthermore, it had 23.509 ± 0.109 mg gallic acid equivalents/gram (GAE/g) and 15.186 ± 0.046 mg quercetin equivalents/ gram (QE/g) of total phenolic and flavonoid compounds, respectively. At 200, 400, and 800 mg/ kg BW doses, S. polycystum had inflammatory inhibition percentages of 53.80 ± 4.68%, 62.35 ± 4.05%, and 60.90 ± 2.88%, respectively. Conclusion: Sargassum polycystum ethyl acetate extract inhibited inflammation. However, further study is needed to examine the safety, identification, separation of the relevant substances involved, and the precise mechanism of action.
Antiparasitic and cytotoxicity effects of 7-hydroxy-4′- methoxy isoflavone against Leishmania major
Authors: Aghaei Mahdi , Alizadegan Farhood , Raziani Yosra , Kishore Githa , Saadatmand Massumeh , Kumar Suja Ajoy
Published: November 2023

Introduction: Leishmaniasis caused by Leishmania spp. is observed in most parts of the world. Although, glucantime, a pentavalent antimony compound, and other synthetic drugs are broadly applied for leishmaniasis therapy; however, the use of these synthetic agents has some limitations. Hence, this study was designed to assess the inhibiting effects of 7-hydroxy4′-methoxyisoflavone (7HMI) against promastigote and amastigote stages of Leishmania major in vitro. Methods: The MTT assay was applied to study the antileishmanial activity of 7HMI against promastigotes and its cytotoxicity effects on macrophage cells. The nitric oxide (NO) produced by the treated macrophage cells with 7HMI was also assessed. Results: 7HMI considerably (P<0.05) inhibited the growth rate of promastigotes and amastigotes stages. The 50% inhibitory concentrations of 7HMI and glucantim were 11.3 and 15.4 µg/mL for promastigote and amastigote, respectively. 7HMI, especially at 1/3 IC50 and 1/2 IC50 concentrations, considerably triggered the NO release. Conclusion: The current research findings reported the favorable antileishmanial effects of 7HMI against L. major with possible mechanisms such as reducing the infectivity rate of macrophage cells and provoking NO creation. Nevertheless, more research must be performed to clear its efficacy in animal model and then in human.
Phytochemical identification and in silico study of ethanolic extract of white cabbage as a phosphodiesterase 1B inhibitor
Authors: Ahmad Nazir , Lesa Kaisun Nesa , Ujiantari Navista Sri Octa , Sudarmanto Ari , Ikawati Zullies , Fakhrudin Nanang
Published: November 2023

Introduction: Memory dysfunction has remained a challenging issue globally. Nootropics have proven fruitful in managing cognitive dysfunction but because of their side effects, opportunities exist to explore alternatives. White cabbage is a cost-effective natural source of phytochemicals without side effects and has remained uninvestigated as a nootropic agent. This study sought to identify secondary metabolites in white cabbage extract (WCE) and to predict the molecular interaction between the phytochemical constituents of cabbage and phosphodiesterase-1B (PDE1B) using in silico studies. Methods: The WCE was prepared by macerating crushed fresh white cabbage with ethanol for 24 h with continuous stirring. The phytochemical profile of WCE was analyzed using thin layer chromatography (TLC)-densitometry, and molecular docking studies were performed to predict the underlying mechanism action of the phytochemicals with PDE1B. Results: The TLC-densitometry analysis showed that WCE was a rich source of sinigrin, whereas quercetin, chlorogenic acid, and rutin were not detected. In silico studies identified neobrassicin as having the highest affinity (∆Gbind: −19.3358 kcal/mol) for PDE1B. However, quercetin (∆Gbind: −13.1813 kcal/mol) and chlorogenic acid (∆Gbind: −14.8706 kcal/mol) exhibited moderate interaction with PDE1B. Conclusion: These results suggest that WCE has the potency to improve memory function by blocking PDE1B, and this preliminary study implies upcoming in vitro and in vivo research.
Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats
Authors: Rath Bandana , Sika Lalit Mohan , Misra Ikhita , Panigrahy Snigdha Rani , Mishra Baidyanath
Published: November 2023

Introduction: Parkinson’s disease (PD) is a neurodegenerative disorder, basically manifested by motor symptoms. However, there are other associated non-motor features in PD, including depression, anxiety, and cognitive impairments that significantly affect the quality of life. Scientific reports have shown that Sargassum wightii, a brown seaweed, protects against rotenone-induced motor deficits, mitochondrial dysfunction, and oxidative stress in rats. We therefore, undertook this study to evaluate its efficacy in alleviating rotenone-induced non-motor symptoms such as anxiety-like behavior and cognitive deficits in rats. Methods: Rotenone at a dose of 10 mg/kg was given orally for 28 days to induce PD model in male rats. The vehicle and the test drug were given orally daily, 1 hour prior to the rotenone administration. The protective effect of S. wightii (methanol extract at 400 mg/kg dosage) was assessed through an array of tests: Elevated plus maze test, Morris water maze test, and novel object recognition test. On the 28th day, the rats were sacrificed, and hippocampal neurobiochemical analyses were performed using high-performance liquid chromatography (HPLC). Results: Co-administration of S. wightii reversed the rotenone-induced anxiety-like behavior and cognitive deficits to a significant extent (P<0.001). It also restored the hippocampal neurotransmitters (5-hydroxytryptamine, dopamine, and 5-hydroxy indole acetic acid) significantly (P<0.001). Conclusion: Sargassum wightii provides neuroprotective effects and reduces the non-motor symptoms of PD. Therefore, it might be a novel insight into PD therapy.
Dual antineoplastic and photodynamic effects of methanolic extract of Tecoma stans yellow flowers for cancer treatment
Authors: Khattab Asmaa Y , Awad Nagwa E , Abdel Fadeel Doaa , Fadel Maha
Published: November 2023

Introduction: Tecoma stans is a fast-growing plant from the family Bignoniaceae. Various parts of T. stans have been used in different biological applications, especially in cancer treatment. Photodynamic therapy (PDT) is a promising modality for cancer treatment that depends on the interaction between a photosensitizer, light, and oxygen. Searching for photosensitizers from plant origin is crucial to provide nontoxic photosensitizers with high economic value. This study aims to evaluate the anticancer and photodynamic activities of T. stans methanolic flower extract (TSFE). Methods: The phytoconstituents of TSFE were analyzed by the UPLC/MS/MS technique. The cytotoxicity of TSFE was examined on the breast carcinoma (MCF-7) and lung carcinoma (A549) cell lines, in dark and after irradiation by blue light (400-450 nm). Results: TSFE contained various phytochemical components with antineoplastic activity. Moreover, TSFE contained coumarins and anthocyanins that may act as photosensitizers. TSFE showed negligible cytotoxicity against MCF-7 cell lines at all tested concentrations in dark. A non-significant cell viability change was observed upon radiation (P>0.05). TSFE showed significant dark cytotoxicity on A549 cells, which improved significantly after light radiation (P<0.05). Conclusion: TSFE is a promising anticancer and natural photosensitizer for PDT and this study may inspire further ethnobotanical investigations into promising new natural anti-cancers and photosensitizers.
Comparative study of the antibacterial and anti-inflammatory activities of the seed coat vs. seed kernel extracts from the plant Mangifera indica L. in inflammatory acne treatment
Authors: Nguyen Ngoc Nha Thao , Vo Duc Linh , Dang Duy Khanh , Huynh Trung Hieu , Ha Cao Thien
Published: November 2023

Introduction: The present study was developed to investigate and compare the extraction yield, the contents of polyphenols and mangiferin, the activities against Propionibacterium acnes, Staphylococcus aureus, and Escherichia coli bacteria, and the anti-inflammatory activities of ethanol extracts of mango seed kernels vs. seed coats. Methods: Mango seed kernels and seed coats were extracted using ethanol as the solvent and tested against microorganisms using the disc diffusion method. The minimum inhibitory concentration (MIC) levels of extracts were determined by the agar dilution method. The anti-inflammatory activities were assessed both in vitro and in vivo by albumin denaturation method and carrageenan-induced paw edema test, respectively. Results: Both extracts yielded high contents of mangiferin and phenolic compounds. The antibacterial activities of both extracts showed inhibition of the tested microorganisms Propionibacterium acnes and Staphylococcus aureus but not Escherichia coli. Seed kernel extract (0.2 g/kg) reduced paw edema by 44.8% at 3 hours after λ-carrageenan administration. Meanwhile, 0.5 g/kg seed coat extract reduced paw edema less than the seed kernel extract (23.1% vs. 44.8%). Mango seed kernel extract, mango seed coat extract, and diclofenac sodium displayed concentration-dependent inhibition of heat-induced protein denaturation with IC50 values of 137.23 μg/mL, 292.12 μg/mL, and 6.64 μg/mL, respectively. Conclusion: The obtained results confirmed the antibacterial and anti-inflammatory potential of mango seed kernel and seed coat extracts. The mango seed kernel extract was proven to be more effective than the mango seed coat extract and thus can be used in cosmetics as an anti-inflammatory and antibacterial agent.
The Effect of Blended Learning Type of Flipped Classroom on Mathematical Problem Solving Ability in Solid Figures Topic
Authors: Ahmad Ahmad , Lukmanul Akhsani
Published: November 2023

This study aimed to find out the ability to solve math problems in solid figures topic before flipped classroom type blended learning was applied to grade IX students of SMPN 2 Sokaraja in the 2019/2020 school year and to know the influence of flipped classroom type blended learning on the problem-solving skills of solid figures topic in Grade IX of SMPN 2 Sokaraja in the 2019/2020 school year.

By looking at the objectives, statistical testing was conducted to test the effectiveness formulated in the research hypothesis. To test the significance of mean differences over two different groups due to the use of multiple treatments on an independent variable can be done with a parametric statistical test using the -t-test. Before conducting parametric statistical tests, the data we obtained must fulfill the requirements of conducting tests with parametric tests including, normal and homogeneous distribution. If the data meets the requirements of a hypothesis test with a parametric test, but if it does not meet the requirements then the hypothesis test is conducted with a non-parametric test.

The previous analysis resulted that the problem-solving skills of students taught with a blended learning model flipped classroom type are better than conventional learning models. Descriptively, when viewed from the average score of overall math problem-solving skills for students taught with a blended learning model flipped classroom type was 44.22, while those taught with conventional models was 38.17.

From the average of each level of math problem-solving ability, the one taught with a blended learning model flipped classroom type was 4.42 and the one taught with conventional learning model was 3.82. It was explained, that the model of learning blended learning type flipped classroom was very influential on the ability to understand problems, the ability to plan solutions, the ability to complete, and the ability to re-examine the results of work
Promoting Students' Creative Thinking Through Activities Exploring The Surrounding Nature: A Stem Project-Based Learning Design For Sets
Authors: Yudha Adinda Salshabilla , Antika Helen Novi , Rusmana Erina Ellen , Kohar Ahmad Wachidul
Published: November 2023

This study aims to describe the process and results of the development of STEM-Surrounding-Nature-Exploration (SNE) integrated with PjBL-based learning materials to improve students' creative thinking skills on sets concepts This is developmental research using the Plomp model to develop learning materials in the form of Teaching Modules and Project Worksheets for set materials with a STEM-SNE integrated project learning design. The trial was conducted on 31 grade 7 students at a junior high school in Surabaya, East Java. Data collection and analysis techniques were carried out using validation sheets to determine the validity of the learning materials tested on the validator. A pre-test and a post-test were used to measure effectiveness related to students' creative thinking on set material. In addition, student response sheets were also used to determine the practicality of the learning materials. Results found that the learning device obtained a validity criterion of 92.5% for the Project Worksheet while 91.25% for the validity of the Teaching Module and each was classified as very valid. For effectiveness criteria, it was obtained n-gain of 0.7512 in the limited trial and 0.71 in the class trial and each of them obtained high effectiveness criteria. Learning materials obtain very practical criteria implemented with an average student response acquisition of 85% and 84% for project learning designs.
Development of Statistical Literacy Questions for Prospective Mathematics Teachers
Authors: Rahma Siska Utari  , Zulkardi Zulkardi  , Ratu Ilma Indra Putri  , Ely Susanti
Published: November 2023

Literasi statistik menjadi salah satu kemampuan penting yang harus dimiliki oleh mahasiswa calon guru matematika di era  masyarakat 5.0. Penelitian ini adalah penelitian deskriptif kualitatif untuk mengembangkan soal literasi statistik bagi mahasiswa calon guru matematika dengan menggunakan indikator lima basis literasi statistik dan prinsip PMRI. Soal dikembangkan dengan menggunakan design research tipe development study untuk melihat kevalidan dan kepraktisan soal. Tahapan penelitian meliputi tahap preliminary, tahapan prototyping (self evaluation, expert review, one-to-one, dan small group). Sebanyak 13 orang mahasiswa calon guru matematika berpartisipasi dalam penelitian ini, dalam tahap one-to-one dan tahap small group. Data dikumpulkan melalui walkthroughs, observasi, wawancara, dan rekaman video. Data dianalisis secara kualitatif untuk mendeskripsikan hasil setiap tahapan. Hasil penelitian menunjukkan bahwa soal literasi statistik yang dikembangkan dinyatakan valid dan praktis. Validitas ditunjukkan dari tahapan expert review yang memvalidasi dari aspek konten, konstruk dan bahasa yang digunakan pada soal. Kepraktisan dilihat dari tahap one-to-one dan small group dimana mahasiswa dapat mengerjakan soal yang diberikan. Perlu penelitian lebih lanjut dengan menggunakan subjek yang lebih banyak untuk melihat efek potensial yang nampak dari penelitian ini.
Blended Learning Through Learning Manajement System In Mathematic Of Statistic And Opportunity : Students’ Perception
Authors: Ahmad Ahmad , Heny Sri Astutik
Published: November 2023

During the COVID-19 pandemic, the conventional education revolution to technology-based education became the world’s spotlight. Online learning activities are one of the most effective solutions during the COVID-19 pandemic. Learning has begin to transition from face-to-face learning to distance learning (online learning) through. Blended learning activities are one of the best options thet can be implemented after the COVID-19 pandemic situation. Student perceptions have a significant part in enhancing students' role, activeness, and progress during the learning process in order to attain learning objectives. As a result, the goal of this research was to find out how senior high school students perception about blended learning though LMS in mathematics. This study employs descriptive quathitative  methods with 47 sudents of grade IX in one of SMP Negeri at Sokaraja as a respondent of the study. Questionaire was used to collect the data. According to the findings of the study, Class IX students' perceptions of online learning in subjects Mathematics in the Covid-19 Pandemic at SMP Negeri 2 Sokaraja are in moderate category with a percentage of 6. percentage of 42.56%.
Ability to Understand Mathematical Concepts and Adversity Quotient Students Reviewed from Al-Qur’an Memorize Ability
Authors: Elma Triana  , Lisa Dwi Afri
Published: November 2023

Peserta didik sering merasa kesulitan dalam memahami konsep yang ada dalam matematika. Kebanyakan dari mereka merasa sulit untuk berkonsentrasi, serta mudah menyerah untuk memahami konsep matematika. Mengenai hal tersebut, adversity quotient sangat diperlukan dalam diri peserta didik. Adversity quotient merupakan faktor internal siswa yang berbentuk kegigihan, tanggung jawab, pengendalian, serta pandangan dalam menghadapi permasalahan. Kegiatan memorize Al-Qur’an diketahui dapat melatih seseorang untuk menjaga ketenangan hati, mudah konsentrasi, serta mengontrol emosi yang ada dalam diri. Tujuan dari penelitian ini yaitu mendeskripsikan kemampuan pemahaman konsep matematis dan adversity quotient siswa ditinjau dari kemampuan menghafal Al-Qur’an (Al-Qur’an memorize ability). Penelitian ini merupakan penelitian deskriptif kuantitatif dengan subjek penelitian yaitu siswa kelas VIII salah satu SMP Swasta di Binjai. Teknik pengumpulan data dalam penelitian ini menggunakan angket, dokumentasi dan wawancara. Analisis data dilakukan dengan statistik deskriptif, yaitu menarasikan/mendeskripsikan hasil angket dan wawancara. Hasil penelitian menunjukkan bahwa kemampuan pemahaman konsep matematika dan adversity quotient dipengaruhi oleh hafalan Al-Qur'an. Subjek Religi (SR) memiliki kemampuan pemahaman konsep matematis tingkat tinggi dan adversity quotient kelompok climbers. Subjek Unggulan (SU) memiliki kemampuan pemahaman konsep matematis tingkat menengah dan adversity quotient kelompok campers. Subjek Dasar (SD) memiliki kemampuan pemahaman konsep matematis tingkat rendah dan adversity quotient kelompok quitters.
Development of PBL-Based Mathematics Teaching Modules to Improve The Mathematical Critical Thinking Skills of Elementary School Students
Authors: Fathira Aprilia Az-zahra  , Hamidah Suryani Lukman  , Pujia Siti Balkist
Published: November 2023

Penelitian ini bertujuan untuk mengembangkan Modul Ajar Matematika Berbasis Problem based learning Terhadap Peningkatan Kemampuan Berpikir Kritis Matematis Siswa SD dan menguji kualitasnya berdasarkan valid, praktis dan efektif. Penelitian ini menggunakan model pengembangan ADDIE (Analyze, Design, Develop, Implement, Evaluate). Penelitian ini dilakukan kepada 23 siswa kelas V SDN Pakujajar CBM. Instrument yang digunakan pada penelitian ini adalah lembar validasi oleh ahli materi dan ahli media untuk menguji validitas modul ajar matematika berbasis problem based learning, angket respon guru dan siswa untuk menguji kepraktisan modul ajar matematika berbasis problem based learning, dan tes kemampuan berpikir kritis matematis siswa untuk menguji keefektifan modul ajar matematika berbasis problem based learning. Teknik analisis data dalam penelitian ini menggunakan Uji Hipotesis dan N-Gain. Hasil penelitian diperoleh (1) Modul ajar matematika berbasis problem based learning termasuk ke dalam kategori sangat valid. (2) Berdasarkan angket respon guru dan siswa dihasilkan respon yang sangat baik mengenai modul ajar yang dikembangkan dan modul ajar matematika berbasis problem based learning termasuk ke dalam kategori sangat praktis. (3) Berdasarkan hasil analisis Uji Hipotesis dan N-Gain menunjukkan adanya peningkatan kemampuan berpikir kritis matematis siswa dengan kategori sedang, maka modul ajar matematika berbasis problem based learning dinyatakan efektif
Development of Animated Videos Based on the Merdeka Curriculum to Improve Students' Mathematical Problem Solving Ability
Authors: Safitri Dista Anggraeni , Hamidah Suryani Lukman  , Aritsya Imswatama
Published: November 2023

Penelitian ini bertujuan untuk mengembangkan video animasi berbasis kurikulum merdeka untuk meningkatkan kemampuan pemecahan masalah matematis siswa sekolah dasar dengan menguji kualitasnya berdasarkan kriteria valid, praktis, dan efektif. Jenis penelitian ini adalah R&D dengan model pengembangan ADDIE (Analyze, Design, Development, Implementation, and Evaluation). Subjek penelitian ini adalah 1 guru dan 23 siswa kelas V di salah satu SD Negeri di Kota Sukabumi. Instrumen yang digunakan dalam penelitian yaitu lembar validasi ahli media dan ahli materi untuk menguji validitas video animasi, angket respon guru dan siswa untuk menguji kepraktisan video animasi, dan tes kemampuan pemecahan masalah matematis siswa untuk menguji efektivitas video animasi. Teknik analisis data yang digunakan yaitu analisis Uji Hipotesis dan N-Gain. Hasil penelitian menunjukkan bahwa (1) Video animasi yang dikembangkan termasuk dalam kategori sangat valid atau sangat layak untuk diuji coba. (2) Guru dan siswa memberikan respon yang sangat baik terhadap video animasi yang dikembangkan dan termasuk dalam kategori sangat praktis. (3) Berdasarkan hasil uji hipotesis dan N-Gain menunjukkan bahwa terjadi peningkatan kemampuan pemecahan masalah matematis siswa dalam kategori sedang sehingga video animasi yang dikembangkan dinyatakan efektif.
Designing Numeracy Assisted E-Learning Using Palembang Tourism Context during the Covid-19 For Pre-Service Primary School Teachers
Authors: Jayanti Jayanti , Zulkardi Zulkardi , Ratu Ilma Indra Putri  , Yusuf Hartono
Published: November 2023

Pembelajaran setelah masa pandemi COVID-19, fasilitas belajar memanfaatkan bantuan  teknologi Informasi (IT) dimana dosen menggunakan platform pembelajaran e-learning SISFO Universitas PGRI Palembang. Penelitian ini bertujuan untuk menghasilkan bahan ajar berupa LKM (Lembar Kerja Mahasiswa) yang berbantuan e-learning sisfo palembang yang valid, praktis serta memiliki efek potensial. Subjek penelitian adalah mahasiswa semester 5 Universitas PGRI Palembang sebnyak 38 orang. Metode Penelitian ini merupakan penelitian design reseach, penelitian pengembangana yang memiliki dua tahapan, yaitu evaluation preliminary, dan evaluation formatif. Evaluasi formatif meliputi evaluasi kurikulum dan bahan ajar, one-to-one dilakukan pada 3 mahasiswa, expert review kepada 3 pakar, dan small group  sebanyak 6 orang and field test dengan mahasiswa calon guru SD. Data dikumpulkan melalui panduan, wawancara, dan dokumentasi tentang framework PISA 2022. Konteksnya adalah student tourism di era COVID-19 materi statistik and geometri. Data dianalisis secara deskriptif. Hasil dari penelitian ini adalah menghasilkan prototipe lembar kerja mahasiswa yang valid, praktis dan memiliki efek potensial cukup baik dimana pembelajaran mendukung numerasi matematika yang sesuai dengan Framework PISA  2022 yang terdiri dari isi, kontruks dan Bahasa, serta konteks, tingkat masalah, dan proses pada pembelajaran matematika itu sendiri.
Una década de divulgación científica no institucional en Navarra (2012- 2022)
Authors: Sevilla Joaquín
Published: November 2023

En este trabajo se describen las principales actividades de divulgación científica realizadas en Navarra en la década 2012-2022 organizadas por asociaciones y por particulares. Se dejan para otros trabajos las iniciativas de instituciones dedicadas expresamente a la ciencia y su divulgación. La imagen general que se obtiene es que ha habido una actividad significativa y, además, creciente con el tiempo si exceptuamos el inevitable parón producido por la pandemia.
Que cuenta de los quehaceres y faenas acontecidas en la forma audiovisual
Authors: Gutiérrez Díez Margarita
Published: November 2023

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Comunicación científica en contextos organizacionales: hacia un «giro organizacional» en la investigación sobre comunicación científica
Authors: Schäfer Mike S. , Fähnrich Birte
Published: November 2023

Mike S. Schäfer, presidente del comité AGORA, Swiss National Science Foundation (SNSF), para el diálogo entre científicos y sociedad, escribe en 2020 un artículo sobre comunicación científica en contextos organizacionales que supone un enfoque novedoso en las referencias sobre comunicación de la ciencia y que se considera especialmente relevante para el análisis de la divulgación científica y para este*. [PV].
La divulgación científica en la Universidad Pública de Navarra. La Unidad de Cultura Científica
Authors: García Iriarte Iranzu , Irisarri Primicia Susana
Published: November 2023

La divulgación científica es una demanda social cada vez más pujante. Las políticas de investigación nacionales y europeas establecen la necesidad de que la investigación responda a los retos globales y, en este sentido, también se fija como objetivo el aumento de la cultura científica de los ciudadanos. Este artículo describe someramente en qué consiste la actividad de divulgación científica de la UPNA y analiza, más en detalle, las acciones y programas de divulgación científica que se desarrollan a través de su Unidad de Cultura Científica. Por último, se plantean algunos retos y posibles líneas de desarrollo futuras.
Cátedra Mujer, Ciencia y Tecnología de la UPNA
Authors: Aranguren Garacochea Patricia , Barrenechea Tartas Edurne , Catalán Ros Leyre , Díaz Lucas Silvia , Jurío Munárriz Aránzazu , Martínez Ramírez Alicia , Millor Muruzábal Nora , Gómez Fernández Marisol , San Martín Biurrun Idoia
Published: November 2023

La Cátedra Mujer, Ciencia y Tecnología de la Universidad Pública de Navarra (UPNA) tiene como objetivo aumentar la participación de las mujeres en campos de ciencia y tecnología. La cultura y la divulgación científicas son el eje principal de la actividad de la Cátedra. Dicha actividad engloba: la representación teatral Yo quiero ser científica, talleres experimentales y conferencias y exposiciones para todos los públicos y edades. Más de 6000 personas han visto la obra de teatro, más de 1500 estudiantes de ESO han participado en los talleres y el material audiovisual ha recibido más de 20 000 visitas.
Vector Auto Regressive (VAR) Model Approach in the Capital Market
Authors: Suyanto Suyanto
Published: November 2023

As an important instrument in the economy, the capital market requires indicators to determine its growth. One of the influencing indicators is the Composite Stock Price Index (IHSG) with various factors that influence it. This research aims to test and analyze the relationship between inflation, exchange rate, BI-rate, and the amount of money in circulation (M2) on the IHSG for the period January 2017-March 2022 using the Vector Autoregression (VAR) method analyzed with Eviews 12. Process results The data in the research provides evidence that the variables only have a one-way relationship, where the R-squared value shows that the independent variables in the model can explain the changes in the dependent variable that occur. A high F-Stat value in the data processing results indicates that the variables in the model have a simultaneous influence on the dependent variable. The implications of this research can provide insight to market players and regulators regarding macroeconomic factors that can influence capital market growth.
A rare case of giant malignant phyllodes tumour and long term survival
Authors:   Oncology Unit, Radiology Department Aminu Kano Teaching Hospital, I. Mustapha Muhammad , A. Gombe Musa ,   Department of Radiology, Gombe State University, Abdullahi Adamu ,   Radiotherapy and Oncology Centre, Ahmadu Bello University Teaching Hospital Zaria.
Published: November 2023

ABSTRACT Background: Phyllodes tumours are rare breast neoplasm. Its clinical spectrum ranges from a benign and locally recurrent form of behaviour to malignant and metastatic forms. The age at risk is between 35 and 45 years. Giant phyllodes tumours are larger than 10cm in diameter. Case Report: Herewith, we present a rare case of giant malignant phyllodes tumour (40x30x20cm) in a young lady who survived 10 years post-treatment in which most literature reported 10-year survival of 23% to 42%. The patient had mastectomy and radiotherapy to the anterior chest wall. Conclusion: A young lady with a giant malignant phyllodes tumour survived 10 years following treatment. Keywords: Long-term survival, Malignant giant phyllodes tumour, Young lady
FIBROBLASTOMA AT THE SACROCOCCYGEAL REGION MASQUERADING AS SACROCOCCYGEAL TUMOUR IN A GIRL: A RARE CASE REPORT
Authors: Bamoria Priyanka , Sehgal Mehak , Saxena Gaurav , Neogi Sujoy , K Ratan Simmi , Kumar Chiranjiv , Kumar Prafull
Published: November 2023

Introduction: The sacral mass in infancy can be sacrococcygeal teratoma (SCT), meningocele, myelomeningocele, rectal abscess,
lymphangioma, hemangioma, lipoma, perineal cyst. This case report describes the presentation, clinical ndings, imaging characteristics and
treatment of a benign lipomatous lesion in the sacrococcygeal region of a 1.5-year-old girl mimicking SCT. The patient presented Case Report:
with a gradually increasing swelling over the sacral region, primarily located towards the left buttock. Local examination revealed a rm, immobile
mass, measuring approximately 10 * 10 cm with no signs of inammation. Imaging reported the lump as lipomatous lesion. Tumor markers were
normal. The mass was excised with primary skin closure. The patient was discharged on the fth post-operative day with minimal wound infection
and ap necrosis. There was complete healing and skin closure in two months, following dressings and debridement. Fibrolipoma is a Conclusion:
rare variant of lipoma, also extremely rare in infancy. Due to the similarity of the clinical pictures with sacrococcygeal teratoma, there was
diagnostic dilemma. The histopathological examination of the excised tissue is the gold standard for diagnosis. The prognosis of brolipoma is
excellent and recurrence is rare unlike sacrococcygeal teratoma.
USE OF NEUTROPHIL LYMPHOCYTE RATIO AND PLATELET LYMPHOCYTE RATIO AS EASILY AVAILABLE SURROGATE MARKERS TO MONITOR GLYCEMIC CONTROL IN TYPE 2 DIABETES MELLITUS PATIENTS.
Authors: Garg Ravi , Singh R. R. , Tripathi Neeraj , Shekhar Tiwari Chandra , Tiwari Shwetambari
Published: November 2023

Introduction- This study aims to evaluate the changes in NLR and PLR with change in glycemic control in type 2 diabetes mellitus patients.
Methods- The present prospective study was conducted over 200 Type 2 DM patients presenting to Department of General Medicine, Hind
Institute of Medical Sciences Barabanki, U.Pduring the study period of October 2021 to September 2022.CBC including neutrophils lymphocytes,
platelet count, NLR,PLR were calculated. Blood glucose FBS, RBS, PPBS and HbA1c were also calculated at time of rst visit in hospital.
Patients were followed up after 3 months and again CBC, blood glucose levels and HbA1c were measured to see the changes in NLR and PLR
with glucose control level. Results- Mean NLR at base line in cases with HbA1c greater than 7 and less than 7 was 4.80±3.12, and 2.98±1.32,
respectively, with p value <0.001. And after 3 months mean NLR in cases with HbA1c >7 and <7 was 4.11±1.96and2.82±1.25 respectively (p
value<0.001). PLR value at base line in cases with HbA1c >7 and <7 was 139.14±91.29and 105.04±49.99, respectively with p value 0.036. And
after 3 months mean PLR in cases with HbA1c >7 and <7 was 126.39±55.25and103.76±35.21 respectively with p value 0.005. Conclusion- We
recommend that the NLR & PLR values of diabetic patients be calculated as they are cheap, easily available and co-relate with glycemic control in
Diabetes Mellitus. The control of NLR & PLR with glycemic control implicates reduction in subclinical inammatory state and thus eventually
the cardiovascular risk.
“SAFETY, EFFICACY, AND ADHERENCE OF DIMETHYL FUMARATE IN PATIENTS WITH MULTIPLE SCLEROSIS- A REAL-WORLD EXPERIENCE”
Authors: Goyal Sheetal , Murumkar Vivek , Sudha Swayang Panda , Bhat Maya , Netravathi M
Published: November 2023

Background:To study the efcacy and safety of DMF (Dimethyl fumarate) and factors related to drug response, switching and adherence of DMF
in the Indian population. We aimed to evaluate the efcacy, safety and tolerability of DMF in multiple sclerosis (MS). A chart review Methods:
was performed for patients treated with DMF in MS from the MS registry maintained at the hospital. We performed analyses to assess relationships
between baseline parameters and DMF efcacy, outcome and Expanded Disability Status Scale (EDSS) progression status. The study Results:
included 37 patients (median follow-up = 27.5 months). The majority had previously been treated with other Disease modifying therapies -DMTs
(59.5%). The average EDSS before DMF was 3.5± 1.8 and average EDSS after minimum 6 months of DMF was 3.01±1.9. During the follow-up
period, 10 (27%) patients switched treatment; eight were due to clinical or radiological relapse. None of them had tolerability issues. Conclusions:
We conrm that DMF shows a good efcacy in both drug-naïve patients and patients switching from other rst-line DMTs with denite
improvement in EDSS.
STUDY TO EVALUATE THE EXPRESSION OF p53 AND her2/neu IMMUNOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA WITH CLINICOPATHOLOGICAL CORRELATION
Authors: Niaz Zahida , George Greeshma Ann , Antony Philips
Published: November 2023

Background: The evaluation of certain prognostic biomarkers in oral squamous cell carcinoma at the time of diagnosis allows the identication of
a subset of patients who may require more aggressive treatment. To evaluate Aim/Objective: the expression of p53 and her2/neu markers in oral
squamous cell carcinoma with clinico-pathological correlation. A retrospecti Materials and Methods: ve study of 30 patients diagnosed with
primary Oral Squamous Cell Carcinoma (OSCC) at the Department of pathology in a tertiary care hospital was conducted and clinico-pathological
correlation was done with the help of morphology and immunohistochemistry using p53 and her 2/neu markers. The study showed a male Results:
preponderance (70%) and the majority were seen in 50-70yr age group (53.3%). 60% of cases presented with ulcero-proliferative lesion. The
tongue proved to be the most common site (46.66%), followed by buccal mucosa (40%). Microscopically well differentiated carcinomas has taken
the lion's share of diagnosed cases (76.6%). Dense sub-epithelial inammation was found in 30% of cases and necrosis in 16.67%. All the cases
were found to be p53 positive with 50% showing p53 over-expression (3+), ve cases (16.6%) showed Her-2/neu positivity and 13.6% showed
combined positivity. Combined positivity of both P53 and her2/neu was found in 13.5% cases which mo Conclusion: rphological diagnosed as
poorly differentiated SCC having poor prognosis.
EXPLORING THE PROS AND CONS OF OSPE: AN ANALYSIS OF STUDENTS' AND FACILITATORS' PERSPECTIVE
Authors: Sil Amrita , Bhattacharya Tridibes , Sil Somdev , Das Suvajit , Das Pradipta , Jayswal Diptiman , Kanti Das Nilay
Published: November 2023

Background: Objective structured practical examination (OSPE) can be utilized to assess knowledge, skill, attitude and communication of the
students. Being an assessment tool incorporating the new Competency based medical education (CBME) curriculum, this method too needs
feedback for improvement and further implementation. A 360 degrees' feedback could be obta Methods: ined using face to face discussions with
the stakeholders where perception and usefulness regarding OSPE and its implementation was assessed by qualitative research. In this study, we
have aimed at evaluating the attitude and perception of OSPE based assessment in Pharmacology on Phase II MBBS students and facilitators using
focus group discussions (FGDs) among students and in-depth interviews (IDIs) among faculty. After each FGD and IDI, data including all eld
notes and recorded audio were transcribed close to the verbatim on the day of data collection. Free listing using Smith's Salience score and pile
sorting exercise was conducted. The data were analysed by Visual Anthropac version 1.0 software. To get the collective picture, two-dimensional
scaling and hierarchical cluster analysis of pile sort data were undertaken. Debrieng of the ndings of free list, pile sorting and FGD to the
participants were done to increase the credibility of the results. Forty-two Results : free-listed items were identied from the FGD. The Pile sorting
exercise identied the following themes such as merits of OSPE, critical appraisal of one's performance, OSPE related feelings and apprehension,
content selection for OSPE, OSPE conduct, criticism of OSPE and modications suggested by students. The students could appreciate their
shortcomings through OSPE stations, self-assessed themselves and realized their pitfalls. Twenty-three free-listed items were detected from IDI.
Four themes were identied such as advantages of OSPE over traditional practical examination, limitations and suggested improvements to the
present OSPE examination, areas in the present OSPE examination that was appreciated and future planning of teaching learning sessions based on
OSPE. OSPE not only assesses the students but is also a valuable l Conclusion: earning tool. The students have self-assessed themselves and will
progress towards being in-depth strategic learners. Students felt that group study and learning in systematic way with proper practice helps in
improving OSPE performance. The faculty emphasized that OSPE can measure psychomotor skills in an objective manner and the teaching
methods should be tuned with the assessment mode. The stress on maintenance and additions to the OSPE question bank showed that they were
eager for further conduct of OSPE.
A COMPARATIVE STUDY OF HYPOFRACTIONATED RADIOTHERAPY VERSUS CONVENTIONALLY FRACTIONATED RADIOTHERAPY IN POST MASTECTOMY BREAST CANCER PATIENTS
Authors: Deepthi G. V. , Subramanian B. V. , Das Pranabandhu , Jilla Swapna , Rao B. Sreenivasa
Published: November 2023

This is a prospective randomized study to compare efcacy and tolerability of hypofractionated radiotherapy (HRT) with conventionally
fractionated radiotherapy (CRT) in post mastectomy breast cancer patients in terms of Acute and late toxicities and Locoregional recurrences. 73
patients were analyzed (36 in HRT arm and 37 in CRT arm) . The median follow up was 8 months (3-19 months). Grade 1acute dermatitis was
observed in 63.8% patients in HRT group and 67.5% in CRT group (p=0.74). Grade 2 dermatitis in 25% of HRT and 24.3% of CRT (p=0.97) .
Grade 1 acute oesophagitis was seen in 63.8% in HRT and 62.1% in CRT (p=0.88). Grade 2 acute oesophagitis was seen in 11.1% in HRT and
16.2% in CRT (p=0.52). 11.1% in HRT group and 13.5% in CRT group experienced grade 1 pneumonitis (p value= 0.75). 16.6% in HRT group and
21.6% in CRT group had grade 1 lymphedema (p value=0.59). 2.7% of CRT group had grade 2 lymphedema that is statistically insignicant
(p=0.32). 27.7% in HRT group and 29.7% in CRT group had grade 1 (p = 0.85). 2.7% in HRT and 2.7% in CRT group experienced grade 2 chronic
dermatitis (p=1.21) . 16.6% In HRT group and 18.9% in CRT group had grade 1 chronic oesophagitis (p =0.80). No grade 3 or grade 4 toxicities
were seen in any group. One patient in CRT group had recurrence at ipsilateral supraclavicular fossa. None of the patients in HRT group had any
loco regional recurrences.