bluuebunny/crossref_metadata_2025 huggingface dataset:
Studying and Optimizing the Take-Off Performance of Three-Surface Aircraft
Authors: Riboldi Carlo E. D. , Cacciola Stefano , Ceffa Lorenzo
Published: March 2022

In the quest for making aircraft more energy-efficient, configuration, and primarily the arrangement and quality of aerodynamic surfaces, play a relevant role. In a previous comparative study by the authors, it was shown how to obtain a significant increase in cruise performance by adopting a three-surface configuration instead of a classical pure back-tailed design. In this paper, an analysis of the same configurations in take-off is carried out, to assess through a fair comparison the potential effect of a three-surface one especially on take-off distance. Take-off is mathematically described by means of a sound analytic approach. Take-off distance is computed for a baseline two-surface aircraft, and in a later stage on a three-surface one. In addition to exploring the performance, a numerical optimization is also deployed, so as to find the best use of both configurations analyzed (i.e., baseline and three-surface) in take-off, and the corresponding top performance. The quality of the optimum, as well as the practical realization of a control link between the yoke and both control surfaces in the three-surface configuration, are analyzed in depth. The paper describes the advantage which can be attained by selecting a three-surface configuration, and proposes some remarks concerning the practical implementation of the maneuver to actually capture an optimal performance.
Automated Piping in an Airbus A320 Landing Gear Bay Using Graph-Based Design Languages
Authors: Neumaier Moritz , Kranemann Stefan , Kazmeier Bernd , Rudolph Stephan
Published: March 2022

System design in an aircraft is still a costly, manual and iterative approach. One major cost driver of changes in system installation are design efforts for creating new pipes in an earlier stage and the costs accumulated during the in service life. To reduce these costs and the time to market, an automation approach with an integrated design optimization encoded in graph-based design languages and executable in a design compiler is proposed. To generate the pipe work automatically, a set of input data (e.g., start- and end-points of a pipe with tangents and fixing positions) is given by the user. It also contains, among others, the weightings for the optimization criteria (e.g., length of the pipe resp. the weight vs. the number of bends) to influence the evaluation of the generated pipes and thereby the final solution. As an initial step in the automatic pipe generation process, a route through the installation space is searched. Subsequently, the installation space is simplified and a respective minimal distance to each obstacle which a pipe should satisfy is added. Then for each pipe an initial solution is estimated and each pipe is optimized by a simulated annealing algorithm. At last, all given requirements are automatically verified. A carried out investigation indicates a polynomial runtime behaviour of the algorithm. The capabilities of the newly developed automated piping are demonstrated on the pipe work in an Airbus A320 landing gear bay.
Path Planning for Self-Collision Avoidance of Space Modular Self-Reconfigurable Satellites
Authors: An Jiping , Li Xinhong , Zhang Zhibin , Zhang Guohui , Man Wanxin , Hu Gangxuan , He Junwei
Published: March 2022

Space modular self-reconfigurable satellite (SMSRS) is a new type of satellite. The research on self-collision avoidance of SMSRS is important for its on-orbit safety but is not completely solved. This paper offers a new method for joint path planning for self-collision avoidance of SMSRS. Firstly, we establish the collision detection model for SMSRS based on forward kinematics and the spherical nonholonomic envelope to detect the collision occurring in SMSRS. Then, to achieve offline path planning in joint space, we proposed the self-collision avoidance strategy, which splices multiple C-spaces based on the pre-defined joint path into a binary map, and then transforms the binary map into a map with the dangerous potential field, and planning algorithms based on a map with the dangerous potential field is proposed to find the optimal collision-free path. The new method is applied to two cases and both find collision-free joint paths for SMSRS successfully, which demonstrates the feasibility of the method. In addition, this study bridges the gap in the study of self-collision avoidance of super-redundant self-reconfigurable satellites.
Comparative Yield and Photosynthetic Characteristics of Two Corn (Zea mays L.) Hybrids Differing in Maturity under Different Irrigation Treatments
Authors: Wang Lei , Ren Baizhao , Zhao Bin , Liu Peng , Zhang Jiwang
Published: March 2022

Effective irrigation strategies are of great significance for improving crop yields. There is an increasing concern that short-season corn hybrids are gradually being encouraged to plant in the North China Plain (NCP) with the development of mechanized grain harvesting, but the photosynthetic characteristics and productivity of short-season hybrids are not well documented. The objective of the study was to investigate the effects of different irrigation treatments on photosynthetic characteristics, dry matter accumulation (DMA) and photo-assimilate translocation (PAT/PT), grain yield (GY) and water productivity (WP) of two corn hybrids differing in maturity. In the experiment plots under the rainout shelter facility, short-season hybrid Denghai518 (DH518) and medium- and full-season hybrid Denghai605 (DH605) were grown under three irrigation levels (severe water stress, T1; mild water stress, T2; and non-stress, T3) by two irrigation methods (flood irrigation, FI; surface drip irrigation, SDI) in 2020 and 2021. The results indicated that non-stomatal limitation (NSL) was the main factor leading to the reduction in photosynthesis during the reproductive stage. Severe water stress significantly decreased net photosynthetic rate (Pn) and chlorophyll soil-plant analysis development (SPAD) value, resulting in lower DMA and GY. The contribution rate of vegetative organ photosynthate before flowering (CRP) decreased with the irrigation levels increasing. DMA, GY and WP of SDI increased by 16.23%, 21.49% and 51.31%, respectively, compared to FI. The yields of DH518 were 7.22% lower than those of DH605. The WP penalty for DH605 was attributed to a relatively larger ET. It suggested that applying the optimum irrigation level (T3) under SDI could increase DMA, GY and WP of summer corn in the NCP.
Economic Viability of Alternative Bedding Material in Broiler Chicken Farming
Authors: Prišenk Jernej , Brus Maksimiljan
Published: March 2022

The aim of this paper is to assess the economic viability of two different bedding materials used in broiler chicken farming processes. The materials considered are wood shavings and slice-dedusted straw. The slice-dedusted straw is considered an alternative type of bedding material produced by a company from Slovenia. While the technological and economic assessment of this type of bedding material has already been researched in the case of horse breeding, it is something new in the case of broiler chicken farming. Data collection is structured from two trials. Trial one (T1) is also known as daily observations, and trial two (T2) involves obtaining input data at the end of the fattening period. During T1, daily observations are focused on collecting data from technical characteristics, and in T2, the percentage of death proportions and average increments are observed, calculated, and considered as economic input data. The cost calculation model is used for the calculation of several different technical-economic indicators, which denote the influence of different bedding materials no economic production viability. Favorable economic results were found for slice-dedusted straw, which shows that this kind of alternative bedding material could be the better option.
Effect of Drought Stress on Potato Production: A Review
Authors: Nasir Muhammad Waqar , Toth Zoltan
Published: March 2022

Potato is the third most consumed crop globally after rice and wheat. It is a short-duration crop, versatile in use, suitable for growing in a wide range of environments, and its production is increasing rapidly. The modern potato is considered a drought-sensitive crop, and it is susceptible to yield loss because of drought stress. Unfortunately, drought severity, frequency, and extent have been increasing around the globe because of climate change. Potato drought susceptibility has primarily been attributed to its shallow root system. However, several studies in past decades have suggested that drought susceptibility of potato also depends upon the type, developmental stage, and the morphology of the genotype, and the duration and severity of drought stress. They have been overlooked, and root depth is considered the only significant cause of potato drought susceptibility. This review combines these studies to understand the varying response of potato genotypes. This review also explores the current potato production scenario and the effect of varying degrees of drought stress on potatoes’ growth, development, and yield. In the absence of drought-tolerant genotypes, agronomic practices should be improved to mitigate drought stress. Late maturing cultivars, nutrient management, mulching, and foliar application of plant growth regulators can be used during prolonged droughts. Irrigation at tuber initiation and the tuber bulking stage during early droughts can reduce the adverse effects of drought.
Association Mapping for Common Bunt Resistance in Wheat Landraces and Cultivars
Authors: Steffan Philipp Matthias , Borgen Anders , Torp Anna Maria , Backes Gunter , Rasmussen Søren K.
Published: March 2022

Common bunt is a seed borne disease of wheat whose importance is likely to increase due to the growing organic seed market, which, in addition to seed phytosanitary measures, relies on genetic resistances towards the disease. Genome wide association studies in wheat have been proven to be a useful tool in the detection of genetic polymorphisms underlying phenotypic trait variation in wheat. Here 248 wheat landraces and cultivars representing 130 years of breeding history were screened for two years in the field for their resistance reactions towards common bunt. The majority of lines exhibited high levels of susceptibility towards common bunt, while 25 accessions had less than 10% infection. Using Diversity Array Technology (DArT) markers for genotyping and correcting for population stratification by using a compressed mixed linear model, we identified two significant marker trait associations (MTA) for common bunt resistance, designated QCbt.cph-2B and QCbt.cph-7A, located on wheat chromosomes 2B and 7A, respectively. This shows that genome wide association studies (GWAS) are applicable in the search for genetic polymorphisms for resistance towards less studied plant diseases such as common bunt in the context of an under representation of resistant lines.
Training Systems for Sweet Cherry: Light Relations, Fruit Yield and Quality
Authors: Stone Cameron H. , Close Dugald C. , Bound Sally A. , Hunt Ian
Published: March 2022

Semi-dwarfing rootstocks have enabled the adoption of high-density orchard systems for sweet cherry. Understanding the effects of training systems on light capture and fruit quality of lateral bearing cultivars early in tree/orchard establishment is lacking. The aim of this study was to investigate light interception and fruit quality over two seasons of 4–5 year-old ‘Kordia’ grafted to ‘Krymsk 5′ rootstock and trained to the 2D planar training systems of upright fruiting offshoot (UFO), super spindle axe (SSA), tall spindle axe (TSA), Bibaum (BB) and steep leader (SL). Average light interception over the two seasons was highest in UFO and SL (69%) followed by BB (66%). Average yield was highest for SSA (15.1 t ha−1) followed by SL (14.5 t ha−1) and UFO (12.7 t ha). There were negative correlations between crop load and fruit dry matter content (r2 = 0.67 and 0.84) and total soluble solids (0.92 and 0.42) in 2019–2020 and 2020–2021, respectively. Our results indicate that sufficient space is required between uprights for lateral bearing cultivars when trained to a planar training system to achieve optimal light interception and fruit quality. This study provides improved understanding to enable the adoption of planar training systems for lateral fruiting cherry cultivars at high-density plantings.
Effects of Age at First Joining and Ewe Genotype on the Performance of Two-Tooth Ewes and That of Their Progeny to Slaughter
Authors: Keady Timothy W. J. , Hanrahan James P.
Published: March 2022

The effects of first-joining age (7 or 19 months) and genotype on ewe performance when joined to lamb at 2 years, and the performance of their progeny, were evaluated using 424 ewes, representing 3 genotypes: Belclare (Bel), Suffolk × Belclare (Suf × Bel) and Suffolk-type (≥75% Suffolk ancestry (Suf75)). Ewes were managed in a grass-based system. Ewes first joined at 7 months were lighter (p < 0.01) at 19 months and immediately post lambing; otherwise, age at first joining had no effects (p > 0.05) on ewes or their progeny and there were no important interactions with genotype. Bel and Suf × Bel had larger litters (p < 0.001) and reared more lambs per ewe joined (p < 0.01) than Suf75. Ewe genotype had no effect (p > 0.05) on proportion failing to lamb, incidence of lambing assistance, lamb mortality, ewe survival to 31 months, or progeny performance. Increasing the body weight of ewes at 7 months of age increased the probability (p < 0.02) of rearing 1 or more lambs at 2 years and there was no interaction with genotype. It is concluded that age at first joining had no negative impact on the performance of ewes or their progeny.
Influence of a Single Dose of Meloxicam Administrated during Canine Estrus on Progesterone Concentration and Fertility—A Clinical Case Study
Authors: Dzięcioł Michał , Szpaczek Aleksandra , Uchańska Oliwia , Niżański Wojciech
Published: March 2022

This case report presents an observation of the influence of meloxicam administration, during the periovulatory phase, on corpora lutea function in the domestic dog (Canis familiaris). A 2 year old female German Shepherd dog, with a level of progesterone suggestive of the periovulatory period (5.97 ng/mL), received a single subcutaneous injection of meloxicam (0.2 mg/kg body weight). In this female, subsequent evaluation to detect the optimal time for mating revealed a strong decrease in P4 (2.77 ng/mL), although it increased to 13.98 ng/mL within the following three days. The same female conceived and delivered a litter of the same size as in a subsequent cycle where meloxicam was not administered. The use of NSAID (nonsteroidal anti-inflammatory drugs), and particularly meloxicam, as a COX-2 inhibitor that influences the production of prostaglandins has been reported as being potentially harmful for ovulation and pregnancy in various species, including humans. In dogs, the secretion of prostaglandin E (PGE) is thought to be important for ovulation and the formation of the corpora lutea, the only source of P4, which is required for pregnancy maintenance. Although previous case reports have indicated an influence of meloxicam administration on CL function in domestic dogs, here, the decreased progesterone level observed directly after a single dose of meloxicam was only temporary, with no negative impact on fertility. Based on our observations, further studies related to the influence of the timing of meloxicam administration on ovarian cycle advancement, as well as the influence of duration of treatment, dosage, and route of administration on progesterone levels, as an indicator of CL function, are required.
A Peek into the Bacterial Microbiome of the Eurasian Red Squirrel (Sciurus vulgaris)
Authors: Olah Diana Ioana , Páll Emöke , Cerbu Constantin , Zăblău Sergiu Dan , Duca Gheorghiță , Suătean Monica Ioana , Potârniche Adrian Valentin , Vasiu Aurel , Spînu Marina
Published: March 2022

Sciurus vulgaris (the Eurasian red squirrel) is native to Europe and Asia, but due to habitat destruction or fragmentation, interspecific competition, and infectious diseases, especially in European island areas the species finds itself at the brink of extinction. The repopulation of such bare habitats requires healthy squirrel specimens, either translocated from other wild habitats or reintroduced to the wilderness following captive breeding. Captivity, nonetheless, has shown an immense capacity to reshape the structure of wild species’ microbiota, adapting it to the less diverse diet and fewer environmental challenges. Therefore, assessing the differences between “wild” and “captive” microbiota in this species could elucidate if special living conditions are needed in order to augment the survival rate of specimens reintroduced into the wild. Furthermore, the microflora profile of the normal flora of healthy red squirrels raised in captivity could support clinicians in addressing infectious diseases episodes and also raise awareness on the zoonotic risk. Hence, this study aimed at documenting the bacterial species carried by S. vulgaris, disclosing overall similarities and variability patterns of the microbiota identified in individuals from two different living environments. We anticipated that the bacterial community would be less diverse in individuals raised in captivity, owing to their restrictive diet and to unchanging conditions in the enclosure. We also hypothesized that there would be a higher prevalence of zoonotic microorganisms in the captive animals, due to the proximity of humans and of other domestic species. To test this, samples (n = 100) were taken from five body regions of 20 red squirrels, both free-ranging and bred in captivity, processed by classical microbiology techniques, and further identified by biochemical assay (VITEK®2 Compact System). A relatively poor bacterial community, comprising 62 bacterial strains belonging to 18 species and 8 different genera, was identified. Most of these microorganisms were reported for the first time in S. vulgaris. With no discrimination between living environments, the highest prevalence (p < 0.001), was registered in Staphylococcus sciuri (60%; 12/20), followed by Escherichia coli (45%; 9/20) and Bacillus cereus (35%; 7/20). The results suggest unremarkable differences in diversity and richness of the resident aerobic microbiota of S. vulgaris, in relation to the living environment.
Avian Cell Culture Models to Study Immunomodulatory Properties of Bioactive Products
Authors: Paradowska Michelle , Dunislawska Aleksandra , Siwek Maria , Slawinska Anna
Published: March 2022

Antimicrobial resistance is becoming a greater danger to both human and animal health, reducing the capacity to treat bacterial infections and increasing the risk of morbidity and mortality from resistant bacteria. Antimicrobial efficacy in the treatment of bacterial infections is still a major concern in both veterinary and human medicine. Antimicrobials can be replaced with bioactive products. Only a small number of plant species have been studied in respect to their bioactive compounds. More research is needed to characterize and evaluate the therapeutic properties of the plant extracts. Due to the more and more common phenomenon of antimicrobial resistance, poultry farming requires the use of natural alternatives to veterinary antibiotics that have an immunomodulatory effect. These include a variety of bioactive products, such as plant extracts, essential oils, probiotics, prebiotics, and synbiotics. This article presents several studies on bioactive products and their immunomodulatory effects tested in vitro and ex vivo using various avian cell culture models. Primary cell cultures that have been established to study the immune response in chickens include peripheral blood mononuclear cells (PBMCs), intestinal epithelial cells (IEC), and bone marrow-derived dendritic cells (BMDCs). Chicken lymphatic lines that can be used to study immune responses are mainly: chicken B cells infected with avian leukemia RAV-1 virus (DT40), macrophage-like cell line (HD11), and a spleen-derived macrophage cell line (MQ-NCSU). Ex vivo organ cultures combine in vitro and in vivo studies, as this model is based on fragments of organs or tissues grown in vitro. As such, it mimics the natural reactions of organisms, but under controlled conditions. Most ex vivo organ cultures of chickens are derived from the ileum and are used to model the interaction between the gastrointestinal tract and the microbiota. In conclusion, the use of in vitro and ex vivo models allows for numerous experimental replications in a short period, with little or no ethical constraints and limited confounding factors.
Antibiotics and ECMO in the Adult Population—Persistent Challenges and Practical Guides
Authors: Gomez Francisco , Veita Jesyree , Laudanski Krzysztof
Published: March 2022

Extracorporeal membrane oxygenation (ECMO) is an emerging treatment modality associated with a high frequency of antibiotic use. However, several covariables emerge during ECMO implementation, potentially jeopardizing the success of antimicrobial therapy. These variables include but are not limited to: the increased volume of distribution, altered clearance, and adsorption into circuit components, in addition to complex interactions of antibiotics in critical care illness. Furthermore, ECMO complicates the assessment of antibiotic effectiveness as fever, or other signs may not be easily detected, the immunogenicity of the circuit affects procalcitonin levels and other inflammatory markers while disrupting the immune system. We provided a review of pharmacokinetics and pharmacodynamics during ECMO, emphasizing practical application and review of patient-, illness-, and ECMO hardware-related factors.
Intestinal Exposure to Ceftiofur and Cefquinome after Intramuscular Treatment and the Impact of Ceftiofur on the Pig Fecal Microbiome and Resistome
Authors: Rutjens Sofie , Vereecke Nick , De Spiegelaere Ward , Croubels Siska , Devreese Mathias
Published: March 2022

Optimization of antimicrobial treatment during a bacterial infection in livestock requires in-depth knowledge of the impact of antimicrobial therapy on the pathogen and commensal microbiota. Once administered antimicrobials and/or their metabolites are excreted either by the kidneys through urine and/or by the intestinal tract through feces, causing antimicrobial pressure and possibly the emergence of resistance in the gastro-intestinal tract. So far, the excretion of ceftiofur and cefquinome in the intestinal tract of pigs has not been described. The objective of this study was to investigate the excretion of ceftiofur and cefquinome in the different segments of the gut and feces after intramuscular administration. Therefore, 16 pigs were treated either with ceftiofur (n = 8) or cefquinome (n = 8), and feces were collected during the entire treatment period. The presence of ceftiofur and desfuroylceftiofuracetamide or cefquinome were quantified via liquid chromatography–tandem mass spectrometry. At the end of the treatment, pigs were euthanized, and samples from the duodenum, jejunum, ileum and cecum were analyzed. In feces, no active antimicrobial residues could be measured, except for one ceftiofur-treated pig. In the gut segments, the concentration of both antimicrobials increased from duodenum toward the ileum, with a maximum in the ileum (187.8 ± 101.7 ng·g−1 ceftiofur-related residues, 57.8 ± 37.5 ng·g−1 cefquinome) and sharply decreased in the cecum (below the limit of quantification for ceftiofur-related residues, 6.4 ± 4.2 ng·g−1 cefquinome). Additionally, long-read Nanopore sequencing and targeted quantitative polymerase chain reaction (qPCR) were performed in an attempt to clarify the discrepancy in fecal excretion of ceftiofur-related residues between pigs. In general, there was an increase in Prevotella, Bacteroides and Faecalibacterium and a decrease in Escherichia and Clostridium after ceftiofur administration (q-value < 0.05). The sequencing and qPCR could not provide an explanation for the unexpected excretion of ceftiofur-related residues in one pig out of eight. Overall, this study provides valuable information on the gut excretion of parenteral administered ceftiofur and cefquinome.
Establishment of Epidemiological Cut-Off Values and the Distribution of Resistance Genes in Aeromonas hydrophila and Aeromonas veronii Isolated from Aquatic Animals
Authors: Woo Soo-Ji , Kim Myoung-Sug , Jeong Min-Gyeong , Do Mi-Young , Hwang Sung-Don , Kim Woo-Jin
Published: March 2022

The emergence of antimicrobial-resistant bacteria is an enormous challenge to public health. Aeromonas hydrophila and Aeromonas veronii are opportunistic pathogens in fish. They exert tremendous adverse effects on aquaculture production, owing to their acquired antibiotic resistance. A few Clinical and Laboratory Standards Institute (CLSI) epidemiological cut-off values (ECVs) against Aeromonas spp. are available. We evaluated antimicrobial susceptibility by establishing 8 ECVs using two analytical methods, normalized resistance interpretation and ECOFFinder. We detected antimicrobial resistance genes in two motile Aeromonas spp. isolated from aquatic animals. Results showed that 89.2% of A. hydrophila and 75.8% of A. veronii isolates were non-wild types according to the oxytetracycline ECVCLSI and ECVNRI, respectively. The antimicrobial resistance genes included tetA, tetB, tetD, tetE, cat, floR, qnrA, qnrB, qnrS, strA-strB, and aac(6′)-1b. The most common tet gene in Aeromonas spp. isolates was tetE, followed by tetA. Some strains carried more than one tet gene, with tetA–tetD and tetA–tetE found in A. hydrophila; however, tetB was not detected in any of the strains. Furthermore, 18.6% of A. hydrophila and 24.2% of A. veronii isolates showed presumptive multidrug-resistant phenotypes. The emergence of multidrug resistance among aquatic aeromonads suggests the spread of drug resistance and difficult to treat bacterial infections.
Idiosyncratic Fitness Costs of Ampicillin-Resistant Mutants Derived from a Long-Term Experiment with Escherichia coli
Authors: Jordan Jalin A. , Lenski Richard E. , Card Kyle J.
Published: March 2022

Antibiotic resistance is a growing concern that has prompted a renewed focus on drug discovery, stewardship, and evolutionary studies of the patterns and processes that underlie this phenomenon. A resistant strain’s competitive fitness relative to its sensitive counterparts in the absence of drug can impact its spread and persistence in both clinical and community settings. In a prior study, we examined the fitness of tetracycline-resistant clones that evolved from five different Escherichia coli genotypes, which had diverged during a long-term evolution experiment. In this study, we build on that work to examine whether ampicillin-resistant mutants are also less fit in the absence of the drug than their sensitive parents, and whether the cost of resistance is constant or variable among independently derived lines. Like the tetracycline-resistant lines, the ampicillin-resistant mutants were often less fit than their sensitive parents, with significant variation in the fitness costs among the mutants. This variation was not associated with the level of resistance conferred by the mutations, nor did it vary across the different parental backgrounds. In our earlier study, some of the variation in fitness costs associated with tetracycline resistance was explained by the effects of different mutations affecting the same cellular pathway and even the same gene. In contrast, the variance among the ampicillin-resistant mutants was associated with different sets of target genes. About half of the resistant clones suffered large fitness deficits, and their mutations impacted major outer-membrane proteins or subunits of RNA polymerases. The other mutants experienced little or no fitness costs and with, one exception, they had mutations affecting other genes and functions. Our findings underscore the importance of comparative studies on the evolution of antibiotic resistance, and they highlight the nuanced processes that shape these phenotypes.
Antimicrobial Peptides: From Design to Clinical Application
Authors: Zhang Chunye , Yang Ming
Published: March 2022

Infection of multidrug-resistant (MDR) bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, brings public health issues and causes economic burden. Pathogenic bacteria develop several methods to resist antibiotic killing or inhibition, such as mutation of antibiotic function sites, activation of drug efflux pumps, and enzyme-mediated drug degradation. Antibiotic resistance components can be transferred between bacteria by mobile genetic elements including plasmids, transposons, and integrons, as well as bacteriophages. The development of antibiotic resistance limits the treatment options for bacterial infection, especially for MDR bacteria. Therefore, novel or alternative antibacterial agents are urgently needed. Antimicrobial peptides (AMPs) display multiple killing mechanisms against bacterial infections, including directly bactericidal activity and immunomodulatory function, as potential alternatives to antibiotics. In this review, the development of antibiotic resistance, the killing mechanisms of AMPs, and especially, the design, optimization, and delivery of AMPs are reviewed. Strategies such as structural change, amino acid substitution, conjugation with cell-penetration peptide, terminal acetylation and amidation, and encapsulation with nanoparticles will improve the antimicrobial efficacy, reduce toxicity, and accomplish local delivery of AMPs. In addition, clinical trials in AMP studies or applications of AMPs within the last five years were summarized. Overall, AMPs display diverse mechanisms of action against infection of pathogenic bacteria, and future research studies and clinical investigations will accelerate AMP application.
Antiseptic Agents for Chronic Wounds: A Systematic Review
Authors: Barrigah-Benissan Koko , Ory Jérôme , Sotto Albert , Salipante Florian , Lavigne Jean-Philippe , Loubet Paul
Published: March 2022

In many parts of the world, antiseptic agents remain non-indicated in chronic wound care. In the current context of bacterial resistance to antibiotics and the development of new-generation antiseptic agents, wound antisepsis represents an asset for the prevention of wound infection. We aimed to evaluate four common antiseptic agents in chronic wound care complete healing. The review protocol was based on the Cochrane Handbook for Systematic Reviews of Intervention and devised in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement guidelines. Five databases and three clinical trials registries were searched from inception to 30 June 2021 without language restrictions. We included randomised trials evaluating the efficacy of antiseptic agents in chronic wound care in adults. Interventions considered were those using antiseptics for cleansing or within a dressing. Risk of bias was assessed using the bias excel tool provided by the Bristol Academy. Evidence quality was assessed using Grading of Recommendation Assessment, Development and Evaluation (GRADE) criteria. Of 838 studies, 6 were finally included, with a total of 725 patients. The included studies assessed iodine (cadexomer or povidone iodine) (n = 3), polyhexanide (n = 2), and octenidine (n = 1). Limited evidence suggested a better wound healing completion with iodine compared to saline (two randomised controlled trials (RCT), 195 patients, pooled RR 1.85 (95%CI (1.27 to 2.69)), moderate-quality evidence). There was not enough evidence to suggest a difference in wound healing using octenidine or polyhexamide. None of the antiseptic agents influenced adverse event occurrence compared to saline.
Antimicrobial Susceptibility and Clinical Findings of Anaerobic Bacteria
Authors: Cobo Fernando
Published: March 2022

Anaerobic microorganisms are the most abundant components of the normal human microbiota; they colonize mucous membranes such as the oral cavity and the gastrointestinal and female genital tracts, and they are common pathogens in human populations [...]
A Systematic Review and Meta-Analysis of Efficacy and Safety of Azithromycin Versus Moxifloxacin for the Initial Treatment of Mycoplasma genitalium Infection
Authors: Kato Hideo , Hagihara Mao , Asai Nobuhiro , Hirai Jun , Yamagishi Yuka , Iwamoto Takuya , Mikamo Hiroshige
Published: March 2022

Mycoplasma genitalium is recognized as a remarkable pathogen since azithromycin-resistant strains and treatment failure have been increasingly reported. Nevertheless, international guidelines still recommend azithromycin as a first-line treatment and moxifloxacin as a second-line treatment. We performed a systematic review and meta-analysis to validate the efficacy and safety of both drugs in the initial treatment of M. genitalium. We systematically searched the EMBASE, PubMed, Scopus, Ichushi, and CINAHL databases up to December 2021. We defined efficacy as clinical and microbiologic cure, and safety as persistent diarrhea. Overall, four studies met the inclusion criteria: one showed clinical cure (azithromycin treatment, n = 32; moxifloxacin treatment, n = 6), four showed microbiologic cure (n = 516; n = 99), and one showed safety (n = 63; n = 84). Moxifloxacin improved the microbiologic cure rate compared with azithromycin (odds ratio [OR] 2.79, 95% confidence interval [CI], 1.06–7.35). Clinical cure and safety did not show a significant difference between azithromycin and moxifloxacin treatments (OR 4.51, 95% CI 0.23–88.3; OR 0.63, 95% CI 0.21–1.83). Our meta-analysis showed that moxifloxacin was more effective than azithromycin at eradicating M. genitalium infections and supports its preferential use as a first-line treatment.
Vitreous Humor Proteome: Targeting Oxidative Stress, Inflammation, and Neurodegeneration in Vitreoretinal Diseases
Authors: Santos Fátima Milhano , Mesquita Joana , Castro-de-Sousa João Paulo , Ciordia Sergio , Paradela Alberto , Tomaz Cândida Teixeira
Published: March 2022

Oxidative stress is defined as an unbalance between pro-oxidants and antioxidants, as evidenced by an increase in reactive oxygen and reactive nitrogen species production over time. It is important in the pathophysiology of retinal disorders such as diabetic retinopathy, age-related macular degeneration, retinal detachment, and proliferative vitreoretinopathy, which are the focus of this article. Although the human organism’s defense mechanisms correct autoxidation caused by endogenous or exogenous factors, this may be insufficient, causing an imbalance in favor of excessive ROS production or a weakening of the endogenous antioxidant system, resulting in molecular and cellular damage. Furthermore, modern lifestyles and environmental factors contribute to increased chemical exposure and stress induction, resulting in oxidative stress. In this review, we discuss the current information about oxidative stress and the vitreous proteome with a special focus on vitreoretinal diseases. Additionally, we explore therapies using antioxidants in an attempt to rescue the body from oxidation, restore balance, and maximize healthy body function, as well as new investigational therapies that have shown significant therapeutic potential in preclinical studies and clinical trial outcomes, along with their goals and strategic approaches to combat oxidative stress.
Nanotechnology as a Tool to Mitigate the Effects of Intestinal Microbiota on Metabolization of Anthocyanins
Authors: Rosales Thiécla Katiane Osvaldt , Hassimotto Neuza Mariko Aymoto , Lajolo Franco Maria , Fabi João Paulo
Published: March 2022

Anthocyanins are an important group of phenolic compounds responsible for pigmentation in several plants. For humans, a regular intake is associated with a reduced risk of several diseases. However, molecular instability reduces the absorption and bioavailability of these compounds. Anthocyanins are degraded by external factors such as the presence of light, oxygen, temperature, and changes in pH ranges. In addition, the digestion process contributes to chemical degradation, mainly through the action of intestinal microbiota. The intestinal microbiota has a fundamental role in the biotransformation and metabolization of several dietary compounds, thus modifying the chemical structure, including anthocyanins. This biotransformation leads to low absorption of intact anthocyanins, and consequently, low bioavailability of these antioxidant compounds. Several studies have been conducted to seek alternatives to improve stability and protect against intestinal microbiota degradation. This comprehensive review aims to discuss the existing knowledge about the structure of anthocyanins while discussing human absorption, distribution, metabolism, and bioavailability after the oral consumption of anthocyanins. This review will highlight the use of nanotechnology systems to overcome anthocyanin biotransformation by the intestinal microbiota, pointing out the safety and effectiveness of nanostructures to maintain molecular stability.
Hypernetwork Representation Learning with the Set Constraint
Authors: Zhu Yu , Zhao Haixing
Published: March 2022

There are lots of situations that cannot be described by traditional networks but can be described perfectly by the hypernetwork in the real world. Different from the traditional network, the hypernetwork structure is more complex and poses a great challenge to existing network representation learning methods. Therefore, in order to overcome the challenge of the hypernetwork structure faced by network representation learning, this paper proposes a hypernetwork representation learning method with the set constraint abbreviated as HRSC, which incorporates the hyperedge set associated with the nodes into the process of hypernetwork representation learning to obtain node representation vectors including the hypernetwork topology structure and hyperedge information. Our proposed method is extensively evaluated by the machine learning tasks on four hypernetwork datasets. Experimental results demonstrate that HRSC outperforms other best baseline methods by about 1% on the MovieLens and wordnet datasets in terms of node classification, and outperforms the other best baseline methods, respectively, on average by about 29.03%, 1.94%, 26.27% and 6.24% on the GPS, MovieLens, drug, and wordnet datasets in terms of link prediction.
Special Issue on “Buildings and Structures under Extreme Loads II”
Authors: Bedon Chiara , Stochino Flavio , Honfi Daniel
Published: March 2022

Exceptional loads on buildings and structures are known to take origin and manifest from different causes, like natural hazards and possible high-strain dynamic effects, human-made attacks and impact issues for load-bearing components, possible accidents, and even unfavorable/extreme operational conditions [...]
1 to 1000 Policy: Controlling Phosphorous Pollution from Tea Farms with Bioretention Cells
Authors: Chen Chi-Feng , Ho Chia-Chun , Liu Hsiu-Feng
Published: March 2022

When implementing nonpoint source pollution control plans, the size or number of required controlling facilities is a very practical issue. However, quantifying nonpoint source pollution is difficult because it is generated by variable and random rainfall events. This study develops a two-stage optimization process to demonstrate the determination of the optimal bioretention cell size for tea farm pollution control. The optimization process was based on a verified watershed-scale model and a verified site-scale model. The verified watershed model was used to obtain total phosphorous (TP) reduction loads. Once the goal of watershed management was decided, the reduction loads were then allocated and the unit reduction loads were determined. Using the unit reduction loads, the verified tea farm model was used to assess the optimal bioretention cell size for tea farms. A case study using the Jinggualiao stream in the Feitsui Reservoir watershed, Taipei, Taiwan was presented. The results showed that the unit tea farm TP reduction loads were 270 g/ha-year and 326 g/ha-year to reach two water quality goals, and a total of 350 m2 and 600 m2 of bioretention cells were needed, respectively. A 1 to 1000 ratio of the standard bioretention cell area to the tea farm area is recommended as a general control rule.
A Fuzzy Logic Reinforcement Learning Control with Spring-Damper Device for Space Robot Capturing Satellite
Authors: Zhu An , Ai Haiping , Chen Li
Published: March 2022

In order to prevent joints from being damaged by impact force in a space robot capturing satellite, a spring-damper device (SDD) is added between the joint motor and manipulator. The device can not only absorb and attrition impact energy, but also limit impact force to a safe range through reasonable design compliance control strategy. Firstly, the dynamic mode of the space robot and target satellite systems before capture are established by using a Lagrange function based on dissipation theory and Newton-Euler function, respectively. After that, the impact effect is analyzed and the hybrid system dynamic equation is obtained by combining Newton’s third law, momentum conservation, and a kinematic geometric relationship. To realize the buffer compliance stability control of the hybrid system, a reinforcement learning (RL) control strategy based on a fuzzy wavelet network is proposed. The controller consists of a performance measurement unit (PMU), an associative search network (ASN), and an adaptive critic network (ACN). Finally, the stability of system is proved by Lyapunov theorem, and both the impact resistance of SDD and the effectiveness of buffer compliance control strategy are verified by numerical simulation.
Special Issue on Optical In-Process Measurement Systems
Authors: Fischer Andreas
Published: March 2022

Optical principles enable precise measurements, down to the quantum mechanical limits, and provide the fastest possible measurement speed: the speed of light [...]
1D and Map-Based Modeling Approaches for Railway Compression Ignition Engine in NRTC Application
Authors: Di Luca Giuseppe , Muccillo Massimiliano , Giardiello Giovanni , Gimelli Alfredo , Di Blasio Gabriele
Published: March 2022

Internal combustion engine-driven railway vehicles play an important role in the sector even today, due to the incomplete electrification of railway routes. However, stringent COP26 environmental rules are driving manufacturers and the scientific community to study more complex or alternative propulsion systems. Therefore, the design of new powertrains is becoming more challenging. Affordable, along with robust, development tools are fundamental for their development and optimization. In this framework, numerical simulation can represent an effective instrument to face these requirements. The proposed study assesses the accuracy of different modelling approaches for the same engine. In particular, a detailed 1D model, a simplified 1D model and a map-based model are compared. Although studies on engine simulation are available in the technical literature, the novelty introduced with this work is the assessment of accuracy and computational times of the engine models, considered by performing the new emission standard Non-Road Transient Cycle (NRTC), which is applied to a specific field such as Heavy Duty (HD) Compression Ignition (CI) engines for railway applications. This study provides new and quantitative results rarely available in the specific literature. The results show that the simplest model, despite its lower accuracy, maintains good predictive results in terms of cumulative fuel consumption and cumulative nitric oxide (NOx) emissions over the cycle considered. In particular, the difference in terms of fuel consumption for the map-based model is within 5% compared with the more detailed models. Moreover, the computational effort required by the simplest model is three orders of magnitude lower compared with the more detailed model. Therefore, as the simulation run-time is the priority, the simplest modeling approach is suitable for the evaluation of the global performance, in view of a more complex systems simulation, such as a hybrid powertrain.
GPS Results from Long Time Monitoring of Geodynamic Processes in South-Western Bulgaria
Authors: Dimitrov Nikolay , Nakov Radoslav
Published: March 2022

Monitoring of geodynamic processes by modern GNSS techniques in the area of Sofia and South-Western Bulgaria has continued for 25 years. To study the modern crustal movements in the area, Global Positioning System (GPS) data acquired between 1996 and 2021 are analyzed to obtain the velocity field for South-Western Bulgaria. For a time period of almost 25 years, the monitoring has covered 28 stations. They have been measured in different years and in a number of campaigns. Despite the difference in the measurements, the obtained results are quite homogeneous in the different localities of the studied area and show clear uniform tendencies. All velocities are in the southern direction. They are in the range of 1.5 mm/year to slightly over 3 mm/year, almost reaching 4 mm/year. The velocities of the stations tend to increase from north (stations around Sofia), passing through an intermediate locality (between Sofia and Kyustendil–Pazardhik), clearly increasing in the southernmost part of the country (around Gotse Delchev). This velocity field motivates N–S expressed extension with increasing rates from North to South. The difference in the velocity rates tends to change along geologically suggested active fault zones. The obtained results generally confirm previously data, but with much better accuracy and details at the local level. This way, both the repeated measurements and extension of the geodynamic network prove to be a powerful tool for a better understanding of present-day geodynamics.
A Feasibility Study of an ESG to Suppress Road Noise of a Car
Authors: Lee Young-Sup , Ryu Seokhoon , Yoo Eunsuk , Lim Chasub
Published: March 2022

This study considered implementing an active road noise control (ARNC) system using an electronic sound generator (ESG) as a secondary actuator to suppress road noise in a car cabin. The ESG was installed to the cowl panel of a test car to generate structure-borne anti-noise by vibrating the panel. A robust multiple-reference single-input single-output (MR-SISO) ARNC algorithm based on the FxLMS was designed. Four 3-axis accelerometers and a microphone were adopted to acquire the reference signals and the error signal for the control algorithm. The radiated sound pressure from the ESG–cowl pair was high enough to suppress the road noise at a car speed of 60 kph. The optimized least number of reference signals and their locations were determined after computer simulation from the measured primary path data. Real-time control experiments showed an A-weighted sound pressure level reduction of 6.0 dB in the average of three dominant road booming noises in 100–250 Hz with the four optimized reference signals at 60 kph. More reference signals gave a further reduction such as 8.3 dB with 12 reference signals. Thus, this study suggests that the ESG coupled with the cowl panel can be an affordable alternative as a secondary actuator in an ARNC system to suppress road noise in a car.