bluuebunny/crossref_metadata_2025 huggingface dataset:
A smartphone-based mindful breathing task with assessment of heart-rate variability for clinically relevant chronic pain, depression, and anxiety: Protocol for a randomized-controlled trial (Preprint)
Authors: Azam Abid , Latman Vered , Katz Joel
Published: March 2019

BACKGROUND

Mindfulness meditation is a commonly used psychological intervention for pain, mood, and anxiety conditions, but can be challenging to practice when dealing with severe symptoms without proper training experience. The Mindfulness Meditation App (MMA) is a supportive training tool specifically developed for the present study, to aid in the practice of mindful breathing using a smartphone.

OBJECTIVE

The aim of the present study is to evaluate the psychophysiological effects of the MMA. Specifically, the study aims to assess parasympathetic functioning using heart-rate variability (HRV; primary outcome), pain and mood symptoms, mind-wandering and present awareness, and breath focus in groups of participants who self-report clinically significant symptoms of chronic pain (CP), depression and/or anxiety (DA), as well as control participants (C) who do not meet criteria for either.

METHODS

The present study is a two-arm randomized-controlled trial (registration #NCT03296007), taking place at York University in Toronto, Canada. Sixty participants in each group of CP, DA, or C (N=180 total) will be pre-screened and randomly assigned by a 1:1 ratio to a mindfulness meditation app (MMA+) condition or a mindfulness meditation condition without the app (MMA-) after a brief stress-induction procedure. In MMA+, participants will practice mindful breathing with a smartphone and press “breath” or “other” buttons at the sound of audio tones if their awareness was on breathing or another experience, respectively. HRV and respiration data will be obtained during rest (5 minutes), stress-induction (5 minutes), and meditation condition (12 minutes). Participants will complete psychological self-report inventories before and after the stress-induction, and after the meditation condition.

RESULTS

Recruitment for the study began in November 2017 and is expected to be completed in July of 2019.

CONCLUSIONS

This RCT will inform the design of mindfulness meditation training tools delivered by apps and web platforms for the treatment of chronic pain, depression, and anxiety conditions.

CLINICALTRIAL

ClinicalTrials.gov: NCT03296007
A tomada da decisão judicial criminal à luz da psicologia: heurísticas e vieses cognitivos
Authors: Andrade Flávio Da Silva
Published: March 2019

A partir dos conhecimentos da psicologia, este ensaio procura primeiro demonstrar como o ser humano, valendo-se de heurísticas, pensa e age para resolver problemas e tomar decisões em seu dia a dia. Em seguida, o estudo busca revelar como as heurísticas são empregadas para a tomada da decisão judicial criminal, comentando-se sobre  os vieses e sobre os poderes e perigos da intuição, ressaltando-se que o juiz jamais deve prescindir do pensamento racional e lógico, desenvolvido a partir do contraditório. Portanto, chama-se a atenção para a necessidade de o juiz conhecer as heurísticas e os vieses de julgamento, de modo que busque tomar decisões de maneira mais deliberativa e menos intuitiva, ainda que haja uma enorme cobrança por celeridade nos tempos atuais. Reforça-se, ao final, a necessidade de se propiciar e exigir uma formação multidisciplinar do magistrado.
Prisão cautelar e prazo razoável na jurisprudência dos Tribunais Superiores brasileiros
Authors: Ryu Daiana Santos
Published: March 2019

Considerando-se que a prisão é a medida cautelar mais gravosa do ordenamento jurídico brasileiro e sua aplicação tem sido banalizada pelo Poder Judiciário, ao haver cerca de 40% de presos provisórios nos estabelecimentos prisionais pátrios, tem-se como escopo da presente pesquisa a realização de um diagnóstico sobre o conteúdo das decisões dos Tribunais Superiores pátrios cujo objeto é a análise da razoabilidade da prisão cautelar. Em suma, pretende-se desvelar como são julgados os habeas corpus e os recursos ordinários em habeas corpusacerca da temática da duração da prisão cautelar, delineando-se o conteúdo de cada decisão e o método empregado para aferição da razoabilidade do prazo da prisão cautelar. Diante dos dados apresentados, conclui-se que há tendência nos Tribunais Superiores pátrios em manter prisões provisórias longas por meio de argumentação genérica, pautada em elementos vagos, o que corrobora certamente com a existência do alto índice de prisões cautelares nos estabelecimentos prisionais brasileiros.
A expansão do Direito Penal europeu frente à subsidiariedade da tutela penal: alternatividade a partir da Mediação Penal de Adultos portuguesa
Authors: Oliveira Teixeira dos Santos Marina
Published: March 2019

Este trabalho baseia-se na relevância das teorias de subsidiariedade da tutela penal e Direito Penal mínimo em confronto com o Direito Penal europeu. Para tanto, inicialmente será traçado um quadro da expansão do Direito Penal europeu, a partir de sua criação e efetivação até a atual competência penal da União Europeia. Em seguida serão analisados os princípios gerais a serem aplicados na análise do Direito Penal europeu, conforme instrumentos e órgãos da própria União e doutrina. Respectivamente, serão tratados: a Carta de Direitos Fundamentais da União Europeia, a Comunicação da Comissão de 2011 e o Manifesto sobre uma Política Criminal Europeia. Por fim, e sem minimizar a importância prática da aplicação em concreto dos princípios estudados, será tratado o instituto da Mediação Penal de Adultos como forma de diversão penal. Instituto este que, por ser instrumento de desjudiciarização, pode ser entendido como alternativa ao Direito Penal tradicional sancionador e, portanto, meio relevante para assegurar a subsidiariedade da tutela penal na União Europeia. Destarte, a partir deste trabalho poderão ser traçadas conclusões sobre o movimento de expansão penal na União Europeia e soluções para que o mesmo não aconteça ilimitadamente, em dissonância com o caráter de ultima ratioda tutela penal.
A justiça restaurativa como mecanismo de horizontalização de conflitos penais e de reconhecimento das vítimas como sujeito de direitos
Authors: Magalhães Barros Bolzan de Morais Flaviane De , Neto José Afonso , Soares Yollanda Farnezes
Published: March 2019

Este artigo discute a necessidade de superação do modelo processual penal fundamentado na neutralização da vítima e consequente expropriação do conflito pelo Estado, como fórmula única para solução do caso penal. Com foco nesse modelo processual, questiona-se se a sua lógica de fato atende às necessidades das vítimas, respeitando seus direitos e garantias fundamentais. Em seguida, indaga-se sobre a necessidade de se discutir, ainda que de forma coadjuvante ao modelo vigente, um novo modelo de solução consensual de conflitos penais, marcado pela construção de procedimentos dialógicos e horizontais como forma de resposta ao delito. Para tanto, o presente artigo possui como marco a noção de justiça horizontalizada, apontada por Nils Christie, que trabalha a importância de se construir uma justiça que se atenha às especificidades dos personagens centrais do conflito penal – ofensores e vítimas – para uma construção participada na decisão do caso penal. Por fim, analisa-se se a Justiça Restaurativa tem potencial suficiente para conferir a autonomia necessária às vítimas para que sejam, efetivamente, compreendidas como sujeitos de direitos.
O perdão do ofendido na cultura jurídico-penal brasileira do século XIX: negociação no século da justiça pública?
Authors: Teixeira Arley Fernandes
Published: March 2019

O presente trabalho tem como objetivo principal o estudo do perdão do ofendido, um instituto penal presente em ambos os códigos penais brasileiros do século XIX, o Código Criminal de 1830 e o Código Penal de 1890. A análise parte, sobretudo, dos livros jurídicos de direito penal e direito processual penal do Brasil no século XIX e procura, primeiramente, compreender o funcionamento legal desse instituto, quais seus critérios de aplicação e como funciona processualmente a capacidade destinada à parte em perdoar e, portanto, encerrar o processo em andamento e, a partir disso, adentrar nas mais importantes discussões doutrinárias sobre o perdão, das quais destacamos o problema dos miseráveis e a questão das ofensas físicas leves. Todas essas discussões tem o intuito geral de compreender o papel destinado às negociações penais no Brasil desse período, que, apesar de presentes ao longo de todo o século XIX, passam por um momento de transformação no final desse século. Por fim, procurou-se posicionar essas discussões e conclusões no contexto de formação do Direito Penal Contemporâneo no Brasil, principalmente a partir da década de 1890, uma década fundamental nessa mudança.
Para uma história da delação premiada no Brasil
Authors: Sontag Ricardo
Published: March 2019

A busca por origens longínquas – em particular na famosa delação de Joaquim Silvério dos Reis no caso da Inconfidência Mineira – realmente corresponde à tarefa do historiador do direito interessado na delação premiada? É possível abstrair as especificidades históricas de uma delação do final do século XVIII para aproximá-la do instituto que veio se construindo ao longo das últimas décadas? A partir de uma análise mais detida dos documentos de época e partindo do pressuposto de que o historiador precisa respeitar a alteridade do passado, o presente artigo pretende diferenciar, ainda que de maneira ainda esquemática, esses dois momentos da história da delação no Brasil. Ao contrário da diluição entre passado e presente, a compreensão histórica da delação premiada permite mostrar os perfeitamente heterogêneos fundamentos e modos de funcionamento dela nesses dois períodos históricos (a lógica das mercês e a lógica do contrato), para além das superficiais analogias até então elaboradas pelas análises históricas existentes.
Las campañas de Porfirio Díaz en el estado de Guerrero
Authors: Hernández Rodríguez Rosaura
Published: March 2019

El artículo refiere las campañas militares del general Porfirio Díaz en el estado de Guerrero durante la Intervención Francesa. Especialmente, aborda el sitio de Taxco.
El zapatismo ante la filosofía y ante la historia, de Otilio E. Montaño
Authors: Montaño Otilio E. , Valero Silva José
Published: March 2019

José Valero Silva presenta el texto El zapatismo ante la filosofía y ante la historia, del 21 de julio de 1913, firmado por el general intelectual Otilio E. Montaño. El documento explica lo que significa el zapatismo desde una perspectiva histórica-filosófica. El escrito pertenece al fondo documental del archivo del general Emiliano Zapata, donado por el general Octavio Magaña a la Universidad Nacional Autónoma de México.
Un olvidado ensayo histórico de don José María Vigil
Authors: Ortega y Medina Juan Antonio
Published: March 2019

Juan Antonio Ortega y Medina analiza e interpreta el ensayo Necesidad y conveniencia de estudiar la historia patria, de José María Vigil, el cual explica la contradicción entre las escuelas históricas española y mexicana como la raíz de un sentimiento de inferioridad y desconfianza en los mexicanos. El autor opina que Vigil fue quien percibió, por primera vez, los valores de una conciencia mestiza como respuesta a la oposición entre aquellas escuelas históricas al revalorar tanto el pasado colonial como el indígena.
El nacimiento de una industria mexicana
Authors: Valadés José C.
Published: March 2019

José C. Valadés explica que, tras la guerra de Independencia, la República Mexicana se quedó en el primer estadío del industrialismo, pues no poseía fuentes de combustión ni yacimientos carboníferos suficientes para el impulso de la alta industria. Señala como determinantes de este proceso la condición rural de México, la falta de materia prima así como la guerra con Estados Unidos y, además, menciona las dificultades económicas, políticas y sociales, contexto dentro del cual fueron creadas numerosas fábricas.
Jorge Martínez Ríos, Tenencia de la tierra y desarrollo agrario de México (Bibliografía selectiva y comentada: 1522-1968)
Authors: Matute Álvaro
Published: March 2019

Reseña
Albert Duchesne, L'expédition des volontiers belges au Mexique. Au service de Maximilien et Charlotte
Authors: Quirarte Martín
Published: March 2019

Reseña
Moisés González Navarro, Población y sociedad en México, 1900-1970
Authors: Pinet Adela
Published: March 2019

Reseña
México en 1812: control político y bebidas prohibidas
Authors: Guedea Virginia
Published: March 2019

Virginia Guedea estudia dos problemas que enfrentaba la administración de la capital novohispana en 1812: ordenar y gobernar a una inmensa población periférica de escasos recursos así como frenar y regular el uso de bebidas embriagantes. Esos conflictos, relacionados entre sí, eran crónicos y se agudizaron con el movimiento insurgente. Guedea analiza, particularmente, lo que refiere a las bebidas alcohólicas y las diversas disposiciones gubernamentales para solucionar el problema. Anexa el Expediente promovido por los vecinos y vecinas de Santa Cruz y La Palma sobre los desórdenes en las vinaterías y tepacherías de sus barrios, 1812, así como un mapa de ubicación.
Los tranviarios en los años veinte: sus luchas e incorporación al aparato estatal
Authors: Rodríguez Miguel
Published: March 2019

Miguel Rodríguez describe las luchas de los tranviarios de la ciudad de México durante los años veinte. Estudia el desarrollo de las diversas huelgas en los periodos presidenciales de Carranza, Obregón y Calles, así como la inserción del sindicalismo tranviario en el movimiento obrero mexicano. Analiza la relación del Estado con las agrupaciones de trabajadores, las divergencias entre la CGT y la CROM, y la manera en que, finalmente, los tranviarios se incorporan a esta última, que era una organización obrera gobiernista.
Doris M. Ladd, The Mexican nobility at Independence, 1780-1826
Authors: Zoraida Vázquez Josefina
Published: March 2019

Reseña
Martha Rodríguez García et al., Emiliano Zapata y el movimiento zapatista
Authors: Matute Álvaro
Published: March 2019

Reseña
Memorias de un militar: el general Vicente Filisola
Authors: Pi-Suñer Llorens Antonia
Published: March 2019

Antonia Pi-Suñer aborda la figura del general Vicente Filisola, cuya importancia en la historia nacional se debe a su participación en la guerra con Texas. La autora comenta que Filisola decidió escribir sus memorias en dos libros, los cuales analiza como fuentes historiográficas y explica que el primero fue elaborado por un redactor anónimo y el segundo por el mismo Filisola. Ambos volúmenes fueron realizados para defender sus acciones, la diferencia estriba en el contenido; el primero aborda como tema principal la guerra de Texas, mientras que el segundo es una autojustificación
Científicos extranjeros en el México del siglo XIX
Authors: Ortega y Medina Juan Antonio
Published: March 2019

Juan Antonio Ortega y Medina señala que el arribo de numerosos científicos extranjeros a México tuvo lugar gracias a la apertura mundial de este país tras su independencia. Además, hace un sumario de las actividades y aportaciones de estos hombres en cuatro ramas científicas durante el México decimonónico.
Porfirio Parra y Gutiérrez. Semblanza biográfica
Authors: Alvarado Lourdes
Published: March 2019

Lourdes Alvarado describe la vida de Porfirio Parra, a quien considera como uno de los principales exponentes del positivismo en México, relata los numerosos logros académicos de este intelectual quien, a pesar de formar parte de la elite porfirista, tuvo que abandonar suCátedra de Lógica que obtuvo al suplir a su maestro Gabino Barreda debido a los cambios académicos de la institución. A Parra se le atribuye un espíritu crítico respecto del régimen, razón por la cual la autora especula un alejamiento con Díaz que terminaría hasta los últimos años de la dictadura.
La frontera norte: de la Independencia a nuestros días
Authors: Piñera Ramírez David
Published: March 2019

David Piñera Ramírez resume las etapas históricas de la frontera norte y destaca que ésta ha tenido una especial relevancia en los episodios más trascendentes del país ya que los conflictos que inician en el centro del territorio son atraídos hacia ella constantemente. Según el autor, la historiografía ha ignorado el papel histórico de la frontera norte y, por ello, es vital estudiarla, pues representa una posibilidad de renovación nacional tanto por su geopolítica como por las relaciones sociales que se dan en ella.
La interpretación histórico-filosófica del pensamiento latinoamericano de Leopoldo Zea
Authors: Ortega y Medina Antonio Juan
Published: March 2019

Juan Antonio Ortega y Medina describe el recorrido intelectual de Leopoldo Zea, resalta su aportación a la historia de las ideas, al análisis del ser mexicano y latinoamericano y afirma que su obra está basada en la libertad y la toma de conciencia. Reconoce que la multiplicación de los estudios latinoamericanos a nivel mundial se debe a Leopoldo Zea.
La guerra de Castas en la obra de Carrillo y Ancona (historia de una disputa por el control social del maya)
Authors: Campos García Melchor
Published: March 2019

Melchor Campos García expone la manera cómo, a través del tiempo, las versiones historiográficas sobre la Guerra de Castas de 1847 han cambiado para ajustarse al contexto de la época en que son contadas. Describe, en especial, el caso del presbítero Crescencio Carrillo y Ancona, cuya visión sobre este conflicto, durante el Segundo Imperio y el Porfiriato en Yucatán, pretendía defender a la Iglesia de la política anticlerical de los liberales, a quienes consideraba los culpables de la guerra civil y del levantamiento de los indígenas mayas.
Reflexiones sobre las diferentes escuelas históricas desde la antigüedad hasta nuestros días
Authors: Benavides Antonio
Published: March 2019

Enrique Plasencia de la Parra presenta y comenta el documento titulado Reflexiones sobre las diferentes escuelas históricas desde la antigüedad hasta nuestros días de don Antonio Benavides y Navarrete, publicado originalmente en París en 1843 y divulgado en México tres años más tarde en el periódico El Tiempo.
Víctor Díaz Arciniega, Querella por la cultura "revolucionaria" (1925)
Authors: Matute Álvaro
Published: March 2019

Reseña
Emeterio Valverde Téllez, Bibliografía filosófica mexicana
Authors: Matute Álvaro
Published: March 2019

Reseña
Rubén Rodríguez García, La Cámara Agrícola Nacional Jalisciense. Una sociedad de terratenientes en la Revolución Mexicana
Authors: Matute Álvaro
Published: March 2019

Reseña
De la desgracia al accidente de trabajo. Caridad e indemnización en el México revolucionario
Authors: Rajchenberg Sznajer Enrique
Published: March 2019

El autor analiza los cambios en las condiciones de los trabajadores mexicanos a raíz de la modernización capitalista posrevolucionaria, particularmente explica la situación de artesanos y campesinos proletarizados. Asimismo, aborda la modificación del concepto moral sobre el obrero hacia una lógica de clase social en la cual las indemnizaciones por accidentes laborales fueron concebidas como obligatorias, hecho que dejó atrás el concepto de caridad. Expone diferentes reglamentos sobre indemnizaciones de empresas y de estados de la república. Anexa cuadros estadísticos.
Examen imparcial de la administración del general vicepresidente D. Anastasio Bustamante. Con observaciones generales sobre el estado presente de la República y consecuencias que éste debe producir
Authors: Matute Álvaro
Published: March 2019

Álvaro Matute presenta un documento elaborado por Lucas Alamán en el cual este último reflexiona sobre la situación de los tres poderes durante el gobierno de Anastasio Bustamante. En el texto, Alamán sostiene que la constitución mexicana, inspirada en los modelos norteamericano y francés, concebía una división de poderes imperfecta ya que otorgaba demasiada autoridad al Congreso; razón por la cuál el conservador proponía conceder más facultades al Ejecutivo.
Ockham y Wittgenstein. Acerca de los alcances y límites de la relación pensamiento-lenguaje
Authors: Martínez Zepeda Jean Paul
Published: March 2019

El análisis del conocimiento se articula en función del lenguaje. Ockham y Wittgenstein plantean la concepción de un mundo desde una dimensión lógica-filosófica configurada por la estrecha relación pensamiento-lenguaje. Construcción desarrollada en función de tres aspectos centrales: primero, los conceptos son signos de las cosas, segundo, las proposiciones describen “estados de cosas”, y tercero, el conocimiento en cuanto “hábitos” es expresado en proposiciones articuladas en función de los “usos” del lenguaje, proposiciones establecidas por el pensamiento considerado como “actividad” y “operación de signos”. En el análisis de determinadas proposiciones a priori reconocemos los mismos límites de la relación pensamiento-lenguaje, en ellas se develan los problemas fundamentales del hombre, ya sea por la tendencia humana a la explicación del mundo como un todo o por la actitud del hombre frente al mismo.
Recasting as a booster of Ag-Pd alloy cytotoxicity: Induction of cell senescence prior to mass cell death
Authors: Cairovic Aleksandra , Stanimirovic Dragan , Krajnovic Tamara , Dojcinovic Biljana , Maksimovic Vesna , Cvijovic-Alagic Ivana
Published: March 2019

The biological quality and chemical composition of alloys used in dental practice change during heat treatment. Often the residues of the previous cast are not disposed of but are reused and recycled until consumed. Thus, manufactured dental restorations have modified biological quality and chemical composition, and compromised biocompatibility. The aim of this study was to investigate the influence of repeated casting on the cytotoxicity of the silver-palladium (Ag-Pd) alloy. Our results showed that repeated casting of the Ag-Pd dental alloy affected its biocompatibility by promoting toxicity against transformed fibroblasts in a contact-independent manner. A strong decrease in cell proliferation, induction of senescence and massive cell death were observed in cultures exposed only to a medium previously incubated with dental alloy samples. The obtained data indicated that toxicity mediated by the accumulation of the Ag, Pd, Cu and Zn cations released from the Ag-Pd material was enhanced by recasting. The induction of cell senescence and subsequent apoptotic and necrotic death were accompanied by amplified intracellular production of reactive oxygen and nitrogen species, suggesting their involvement in the cell destruction process. Therefore, compromised biocompatibility after recasting with the Ag-Pd alloy can be the cause of serious local cell destruction, as observed in clinical practice.
Convergence of electricity consumption in Turkey: Spatial panel data analysis
Authors: Akarsu Gülsüm , Berke Burcu
Published: March 2019

The issue of convergence has been discussed in many theoretical and empirical studies. Because per capita electricity consumption is considered as an indication of economic development, this study aims to determine the presence of ?absolute and conditional beta (?) convergence? of per capita total electricity consumption across the provinces of Turkey between 1986 and 2013. This work is the first investigation of electricity consumption convergence in Turkey. Based on the annual balanced panel data and the spatial panel data model, our findings indicate absolute ? convergence of per capita electricity consumption across the provinces of Turkey. We conclude that regional policies are successful in reducing regional disparities in per capita electricity consumption among the provinces of Turkey. However, other indicators of economic development should be examined to determine the overall convergence.
New high-order conservative difference scheme for regularized long wave equation with Richardson extrapolation
Authors: Hu Jin-Song , Li Jia-Jia , Wang Xi
Published: March 2019

Numerical solution for the regularized long wave equation is considered by a new three-level conservative implicit finite difference scheme coupled with Richardson extrapolation which has the accuracy of O(? + h4). The scheme is a linear system of equations solved without iteratio. The conservation properties of the algorithm are verified by computing the discrete mass and discrete energy. Existence and uniqueness of the numerical solution are proved. Convergence and stability of the scheme are also derived using energy method. The results of numerical experiments show that our proposed scheme is efficiency.
Genetic algorithm-based heat transfer enhancement technique of a protruded micro-channel
Authors: Yang Ke , Zheng Zhaoli , Zhang Di
Published: March 2019

As an innovative type of passive flow control structure, the protrusion exhibits great potential for heat transfer enhancement. In this paper, genetic algorithm is used for the dimensional optimization of a protruded micro-channel. The protruded micro-channel is studied at four mass-flow rates. In all the cases, thermal performance is selected as the objective function that represents both heat transfer and flow friction. The radius of the protrusion and the distance are selected as the two optimized parameters, and their ranges are decided by physical topologies. The objective function thermal performance is calculated by an auto-CFD batch program. The results shows that there are two peaks of thermal performance values when R and ? change in the cases with flow rates equaling 4 ? 10?5 kg/s and 6 ? 10?5 kg/s, while at the other two flow rates, the thermal performance values increase monotonously. The global optimal solutions for the four flow rates and two local optimal solutions are given in this research, and it is helpful to choose the best design variables to achieve the highest thermal performance. It also can be found that at all the different flow rates, the optimized shape of micro-channel has the same point that (R-?) is nearly 45 ?m in the studied ranges of optimized parameters.
Effect of temperature on gas seepage characteristic based on coal-gas interaction model
Authors: Xue Yi , Cao Zhengzheng , Dang Faning , Liu Yang , He Mingming
Published: March 2019

The temperature has a significant impact on the coal seam gas extraction. A fully coupled model is established in this study, which takes into account the coal-gas interaction characteristic. The numerical result shows that the coalbed CH4 migratio and transport evolution coal bed CH4 reservoir is not only dependent on the coal matrix deformation, gas pressure and gas adsorption, but also closely related to temperature.
Accidental colchicine poisoning with fatal outcome after ingestion of meadow saffron (Colchicum autumnale L.) - Report of autopsy case
Authors: Danilovic Milos , Isailovic Jelena , Aleksic Ivan , Dzambas Jelena , Marinkovic Nadica
Published: March 2019

Introduction. Meadow saffron (Colchicum autumnale L.) is a perennial herbaceous plant belonging to the Lily family (Liliacea). It is similar to the edible wild garlic (Allium ursinum L.). Toxic substance in meadow saffron is alkaloid colchicine. Colchicine poisoning is a very dangerous condition which can lead to a fatal outcome. Case report. A 50-yearsold male was addmited to the hospital complaining of weakness, abdominal pain, nausea, vomiting and diarrhea without blood. The day before, the patient ate two plants thinking they were wild garlic and seven hours after ingestion he felt first symptoms. During the course of the hospital stay, he had gastroenterocolitis, acute renal faliure, hepatic lesions and cardiorespiratory insufficiency with a fatal outcome. Post-mortem examination revealed: brain oedema, lung oedema and congestion, heart weighing 700 g with ventricular hypertrophy, myocardial fibrosis, liver congestion and steatosis, spleen congestion, pancreatic fibrosis. Organs sections were taken for histopathological analysis. Body fluids and parts of organs were toxicologically analyzed. Histopathological findings were: brain oedema, diffuse perivascular and interstitial myocardial fibrosis, myocardial haemorrhage, lungs congestion and oedema, microvesicular and macrovesicular liver steatosis, centrilobular liver necrosis, lymphocytic inflammatory infiltrate in liver portions, red pulp congestion of the spleen, kidney congestion and interstitial bleeding, coagulation necrosis of the proximal tubules of the kidney. Toxicological analysis showed colchicine in the blood ? 0.011 mg/L, urine ? 0.051 mg/L, liver with gallbladder ? 0.007 mg/kg, kidney ? 0.008 mg/kg. Conclusion. Ingestion of meadow saffron can lead to poisoning with a fatal outcome due to the presence of the alkaloid colchicine. Colchicine intoxication should be suspected in patients with gastrointestinal symptoms after consuming wild plants.
The effect of dental caries and restorative biomaterials on IL-1 β and TNF-α levels in the gingival crevicular fluid
Authors: Stefanovic Vladimir , Taso Ervin , Kanjevac Tatjana , Abazovic Dzihan , Rakic Mia , Petkovic-Curcin Aleksandra , Acovic Aleksandar , Vojvodic Danilo
Published: March 2019

Background/Aim. In the spirit of personalized medicine, determining caries biomarkers in the saliva and gingival crevicular fluid (GCF) attracts great attention in the current dental re-search. The concentration of GCF cytokines is illustrative in depicting the processes in tooth structures. Their relevance must be inspected with aspects of tooth position and caries lesion level. Different impacts of dental restoration materials on GCF IL-1? and TNF-? could be used as a parameter for estimating local inflammation. This paper aimed to estimate the concentrations of the proinflammatory cytokines (IL-1? and TNF-?) in the GCF and to correlate them with caries extension, tooth position, and different restorative biomaterials. Methods. GCF samples were collected from 90 periodontally healthy patients demonstrating at least one tooth with proximal caries and one intact tooth, at the baseline, 7 and 30-days post-treatment. The biomarkers? profile was investigated in relation to different levels of caries extension (superficial, pulpitis, gangrenous, root affection), defect size, and restorative biomaterial. Results. Before therapy, caries level was significantly associated with GCF IL-1? concentration, demonstrating the lowest level in gangrenous (C4) and superficial caries (C2). Thirty days after therapy, root affection (C5) was characterized by the highest IL-1? concentration. Different dental fillings showed various GCF cytokine changes. CPC induced a significant IL-1? increase in more than 70% of treated patients. Caries lesion size was insignificantly associated with GCF levels of these proinflammatory cytokines, where larger defects were followed by an average cytokine increase. Considering the tooth position be-fore therapy, IL-1? had the highest level in GCF samples from caries-affected canines and second molars, while TNF-? showed the highest levels from canines GCF. Dental restoration induced cytokine increase in canines (IL-1? and TNF-?), 1st and 2nd molars GCF (IL-1?). Conclusion. Inflammation intensity of tooth structures was directly reflected in IL-1? and TNF-? concentrations. Dental restoration significantly affects IL-1? and TNF-? levels, depending on the used dental filling-type material. The profile of these cytokines varied in GCF samples of the tooth with different anatomical positions, where canines and molars demonstrated the highest level. An increase of these proinflammatory cytokines in the absence of any symptomatic manifestation of the inflammatory response can be considered as a possible tooth reparation parameter.
Использование гликопротеина GP для создания универсальной вакцины против лихорадки Эбола
Authors: Должикова И. В. , Тухватулин А. И. , Громова А. С. , Гроусова Д. М. , Тухватулина Н. М. , Токарская Е. А. , Логунов Д. Ю. , Народицкий Б. С. , Гинцбург А. Л.
Published: March 2019

Болезнь, вызванная вирусом Эбола (БВВЭ) — одно из самых высоколетальных вирусных заболеваний, поражающих человека и приматов. Возбудителем БВВЭ является вирус Эбола. В настоящее время известно шесть видов этого вируса, три из них патогенны для человека — это виды Заир (ZEBOV), Судан (SUDV) и Бундибугио (BDBV), вызывающие острые вирусные высоконтагиозные лихорадки у людей и приматов с летальностью до 90%. В большинстве случаев БВВЭ вызвана видом ZEBOV. Разработка вакцин против БВВЭ началась сразу после идентификации возбудителя в 1976 г. На сегодняшний день в мире зарегистрировано четыре вакцинных препарата для профилактики БВВЭ. Все они основаны на протективном антигене — гликопротеине (GP) вируса Эбола вида ZEBOV. В силу того, что виды SUDV и BDBV также могут быть причиной вспышек и эпидемий БВВЭ, очевидна необходимость разработки вакцин, способных обеспечить защиту от всех известных патогенных для человека видов вируса Эбола. В статье систематизированы данные относительно структуры, иммуногенных и протективных свойств GP вируса Эбола, проведен анализ иммунодоминантных эпитопов гликопротеина вирусов ZEBOV, SUDV и BDBV, необходимых для формирования протективного иммунитета, а также предложен рациональный, на наш взгляд, подход создания возможных вариантов вакцин против БВВЭ, вызванной разными видами вируса Эбола, состоящий в использовании векторных конструкций, экспрессирующих как минимум два варианта гликопротеина — GP вируса Эбола вида ZEBOV и вида SUDV.
Анализ корреляции содержания цитокинов периферической крови с риском развития сердечно-сосудистых осложнений у больных эссенциальной артериальной гипертензией II стадии
Authors: Радаева О. А. , Симбирцев А. С.
Published: March 2019

Эссенциальная артериальная гипертензия (ЭАГ) остается наиболее распространенным модифицируемым фактором риска сердечно-сосудистых заболеваний и смерти. Целью исследования было выявить корреляцию содержания цитокинов (интерлейкинов, молекул адгезии, факторов некроза опухоли, роста и др.) в сыворотке периферической крови и частоты осложнений (инфаркта миокарда, острого нарушения мозгового кровообращения) в последующие 5 лет у больных ЭАГ II стадии. У 200 пациентов с ЭАГ II стадии с длительностью заболевания 10–14 лет, получавших сопоставимую гипотензивную терапию и показавших целевые уровни АД, с помощью ИФА в сыворотке периферической крови определяли содержание 28 цитокинов (IL1β, IL1α, IL1ra, IL18, IL18BP, IL37, IL6, sIL6r, LIF, sLIFr, IGF-1, IGFBP-1, TNFα, sTNF-RI, sVCAM-1, IL17, IL2, IL4, IL10, TGF-β1, IL8, CX3CL1, CXCL10, INFγ, M-CSF, IL34, VEGF-A, эритропоэтина) и вазоактивных пептидов (NО, iNOS, eNOS, ADMA, SDMA, Nt-proСNP, Nt-proBNP). В течение последующих 5 лет фиксировали случаи развития осложнений. Ретроспективный анализ показал, что для группы с развитием осложнений в последующие 5 лет характерно предварительное снижение уровней IL1ra (р < 0,001) и IL10 (р < 0,001) на фоне повышения содержания IL1β (р < 0,001), TNFα (р < 0,001) и M-CSF (р < 0,001) в сыворотке крови при сравнении с группой без осложнений. Многофакторный анализ с включением в регрессионную модель Кокса ряда показателей: IL1β > 18,8 пг/мл; IL1ra < 511 пг/мл; IL6 > 23,8 пг/мл; IL10 < 26,3 пг/мл; 389 пг/мл < M-CSF < 453 пг/мл; ADMA > 0,86 мкмоль/л; общий холестерин > 4,9 ммоль/л; ЛПНП > 3,0 ммоль/л; ЛПВП у мужчин < 1,0 ммоль/л; у женщин < 1,2 ммоль/л выявил независимый характер «влияния» на повышение частоты повреждения органов-мишеней при ЭАГ II стадии следующих показателей: содержания M-CSF в диапазоне 389–453 пг/мл (р < 0,001), а также уровня ЛПНП более 3,0 ммоль/л (р < 0,01). Изменение уровня цитокинов является патогенетически обоснованным предиктором повреждения миокарда и головного мозга у больных ЭАГ II стадии, а определение уровня M-CSF в крови может дополнить классические схемы расчета риска развития сердечно-сосудистых осложнений у данной категории больных.
Инъекционный коллаген в коррекции возрастных изменений кожи: экспериментально-клинические параллели
Authors: Мантурова Н. Е. , Стенько А. Г. , Петинати Я. А. , Чайковская Е. А. , Болгарина А. А.
Published: March 2019

Возрастные изменения лица в виде морщин, дряблости кожи во многом связаны со структурными изменениями дермы, в том числе с фрагментацией и дезорганизацией коллагеновых волокон. Различные методы косметологической коррекции направлены на активизацию неоколлагенеза и ремоделирование дермы. С этой точки зрения логичным видится проведение внутрикожных инъекций препаратов экзогенного коллагена. Целью исследования было изучить эффективность и безопасность применения коллагенового комплекса Коллост 7% в коррекции возрастных изменений кожи лица, а также уточнить возможные механизмы развития эффекта омоложения кожи после курса внутрикожных инъекций. В исследование были включены 34 участницы, завершили его 30 участниц. Оценка комплекса показателей возрастных изменений кожи с помощью клинических шкал продемонстрировала выраженное улучшение качества кожи и разглаживание ее рельефа, особенно в области локализации тонких морщин. После завершения курса лечения достоверно повысилась эластичность кожи лица, что вкупе с изменениями, выявленными при УЗ-сканировании (повышение толщины дермы и ее акустической плотности), косвенно свидетельствует о структурной перестройке кожи с накоплением белковых волокнистых структур. Полученные результаты позволяют проводить параллели с данными экспериментальных исследований, показывающими активизацию неоколлагенеза в коже лабораторных животных после курсового введения геля Коллост 7%. Серьезных нежелательных явлений при проведении исследования не выявлено. Курсовое внутрикожное введение коллагена можно рекомендовать как процедуру эстетической коррекции, а также в качестве профилактики развития атрофических процессов, которые существенно сказываются на внешнем виде и здоровье кожи.
Частота нарушений углеводного обмена у пациентов дневного стационара с пограничными значениями гликемии натощак и хотя бы одним фактором риска развития сахарного диабета
Authors: Боева В. В. , Боева Т. А. , Завьялов А. Н.
Published: March 2019

С целью оценки диагностики нарушений углеводного обмена проведено обследование пациентов, поступивших в дневной стационар Тамбовского областного государственного бюджетного учреждения здравоохранения (ТОГ БУЗ) «Тамбовская Центральная районная больница» в период 6 месяцев 2018 г. Проведенное в рамках дневного стационара обследование 91 человека позволило выявить у 31 (34,0%) человека сахарный диабет 2-го типа (СД), у 6 (6,5%) нарушенную гликемию натощак и у 22 (24,1%) нарушенную толерантность к глюкозе. Данное обследование показало необходимость расширения популяции скрининга в группах риска по развитию сахарного диабета 2 типа. Дано обоснование проведения перорального теста толерантности с 75 г глюкозы всем лицам с глюкозой венозной плазмы натощак ≥ 5,6 ≤ 6,0 ммоль/л, имеющим один или более факторы риска развития СД 2 типа и/или метаболический синдром: среди данной категории СД был выявлен в 4,3%, а предиабет — в 14,4% случаев.
Implementasi Kurikulum Sekolah Alam dalam Menjawab Tantangan Abad 21
Authors: Safar Mira Purnamasari
Published: March 2019

Indonesia as a country that has the wealth of natural resources, human resources and cultural resources, has a dream to become a great nation and aligned with other nations. Education is one of the keys to success for Indonesia to achieve its goals. The state made various efforts in the framework of educating the nation assisted by the community. In 1998 a group of community initiated a concept of education known as the Green school. Green school has two great vision, which are: (1) Establish rahmatan lil alamin generation, (2) Indonesia as green and peaceful country. Currently, the development of green school in Indonesia are very rapidly both in terms of quality and quantity. This journal is based on qualitative research of a case study on Bogor green school and Baturraden green school studied during July-August 2016. Data were collected through participant observation, in-depth interviews, triangulation and documentation while data analysis techniques using Spradley. The results showed that the curriculum of green school are capable of forming students akhlakul karimah, students logical thinking, leadership and entrepreneurial spirit of students as a preparation to face the challenges of the 21st century.
The Implication of Leadership Concept in Hadith Towards Islamic Education
Authors: Afandi Rahman
Published: March 2019

Leadership plays a very important role on the direction, goals, and the success level in reaching the goals that have been set. Education is one form of organization where success is largely determined by the level of management and leadership factors. This fact shows just how big a role of leadership in education. Therefore, improvement of management systems and leadership in education is a compuilsory.
Manajemen Pendidikan Secara Manusiawi: Studi Kasus Terhadap Manajemen Pengajaran Tenaga Pendidik Man 2 Brebes Di Bumiayu
Authors: Asikin Asikin
Published: March 2019

The number of productive age of Indonesian population will reach the highest rate in the year 2035. Thisachievement actually begins in 2010. Since it is something new after this nation got its freedom, the government makes a lot of effort to make sure that the large  number of productive age population is in line with its high quality as well. The linearity of quantity and quality is then called by the demographic bonus (bonus demografi) which the national development enables to take advantage of it. However, if the condition both the quantity and the quality of the population is upside down between one to another itpossibly becomes disastrous demographic (bencana demografi) (Kemendikbud, 2013: 7). Many efforts have been carried out to pursue the demographic bonus. One of them is through the national education together with its management which emphasizes on pupils’ integrated multi-intelligence. Education and management are like two sides of coin. It brings many issues.  One of them is about humane education management issue. Most of educators and experts pay a little attention tothe humane education management in the teaching and learning activities (KBM, for short) in this country since they think it naturally goes on. At State Islamic Senior high School (MAN,for short) 2 Brebes is one for instance. Becoming the only state Islamic State Senior High School in southern District of Brebes, MAN 2 Brebes experiences quite good progress in the last five (5) years due to the academic and non-academic achievement. This paper describes the humane education management implemented by educators in MAN 2 Brebes. The type of research used in this paper is a qualitative case study approach. The research location is at MAN 2 Brebes. The subjects of the study consisted of Principal, Vice-Principals, Teachers, students and also Administration Staff. The Data Collection technique in this research is taken through interview, observation, documentation, and questionnaire.  The data validation test is done by triangulation and data collection techniques. The data analysis was performed with data reduction, display and conclusion. The result showed that humane education management that is carried out humanly in MAN 2 Brebes treats the learners humanely rather than the reverse such as bullying done by teachers or among students, theft, and other crime. Humane education management conducted in MAN 2 Brebes has a number of purposes. Among others are: 1). giving motivation for students, 2). initiating to self-concept, 3). Developing and improving creativity, 4). leading to positive curiosity, 5). reducing anxiety, and 6). escaping from  being  a stranger at madrasa.
Lesson Study dan Implikasinya Terhadap Pembelajaran Berbasis Kurikulum Tingkat Satuan Pendidikan
Authors: Harsution Vian
Published: March 2019

Lesson study is a systematic, collaborative, and sustainable method of improving the quality of learning. Lesson study emphasizes the exploration of students’ learning needs; teacher openness towards learning difficulties encountered; the willingness of teachers to receive and provide advice and solutions to the difficulties encountered; and the consistency of the various parties to follow up the suggestions and solutions. Implementation of lesson study involving teachers, principals, and experts in the field of education. Kurikulum tingkat satuan pendidikan or abbreviated KTSP is operational curriculum formulated and implemented by each educational unit. KTSP has the characteristics, namely: giving broad autonomy to the educational unit, involving the community and parent participation, involving the democratic leadership of the principal, and require the support of a working team that is synergistic and transparent. KTSP based on the learning process, needs to be supported by a conducive learning environment and fun to be created by teachers.Teachers and principals in a professional, systematic and collaborative create an atmosphere that fosters independence, tenacity, entrepreneurial spirit, adaptive and proactive nature of the learning process. Thus, the learning needs of students who fulfilled optimally and professional ability of teacher who have increased on an ongoing basis, may usher in success – based learning KTSP. It means that the lesson study provides positive implications for the KTSP – based learning.
Communication and Collective Mentality: Pathways of Mobilisation in Colonial America
Authors: King Megan Elizabeth
Published: March 2019

The political upheaval that comprised the American Revolutionary era instigated a new social, political, and intellectual consciousness which ultimately shaped an inclusive national identity for colonists from New Hampshire to Georgia.  In order to comprehend the depth of such a transformative historical event, it is critical to examine the extensive process that emboldened the colonists, leading them from reluctant opposition to legitimised resistance and finally to the establishment of an organized network which aired American grievances and advertised protests, boycotts, and public denouncements of those deemed unpatriotic.  By evaluating the radical developments of the Imperial Crisis via the lens of contemporary scholarship on radicalisation and mobilisation, historians can gain an improved perspective on exactly how eighteenth-century Americans were able to transform mass congregation into a means of political influence. As the study of extremism has been brought to the forefront in recent years, scholars have come to consider radicalisation as a process comprised of discrete developmental phases in which an individual acquires and demonstrates beliefs, feelings, and actions in support of any given group or cause in conflict.  With regard to Colonial America, friendships, networks, and committees of correspondence not only moulded a collective mentality, but additionally enabled individuals who previously had no significant role in political affairs to actively participate in local decision-making processes.  The Patriot movement burgeoned as a direct result of the fact that they were able to provide discontented and disadvantaged citizens with hope for the future and a definite degree of insurance against misfortune for the present.
An Ovidian Poetics of Exile: Renaissance Crossovers with the Tristia
Authors: Buckingham Sophie Jane
Published: March 2019

This article foregrounds some of the basic principles contained within Ovid’s Tristia, a series of epistles written whilst he was exiled from Augustan Rome in A.D. 8. It seeks to find nuances and reapplications of this long-overlooked work in Renaissance England, and looks at translation practice and poets of the sixteenth century who were indebted to Ovid’s ‘exile poetics’ in their own compositions.
A Review of History of Violence
Authors: Horne Alice
Published: March 2019

Though far from perfect, Lorin Stein’s translation of Édouard Louis’ second novel, History of Violence, is certainly compelling. Read as a “crossing” between languages, the translation can never be a “faithful” equivalent, but it can (and does) allow an Anglophone reader to experience the brutal honesty and raw emotion of Louis’ original.
Acknowledgements
Authors: Qureshi Masuda
Published: March 2019

Acknowledgements for the third issue of Brief Encounters