bluuebunny/crossref_metadata_2025 huggingface dataset:
Perancangan Konsep Kreatif Video Profil Desa Rancagong Sebagai Sarana Pengembangan Potensi Desa
Authors: Tanrere Rezki Gautama , Alfayadh Mohammad Dody , Ramadhani Syarurie , Taufiqulhakim Attirmidzi Irzan
Published: January 2025

Desa Rancagong yang berlokasi 12 km di sebelah Barat Daya Kota Tangerang tepatnya di Kecamatan Legok memiliki potensi dalam menunjang aktivitas ekonomi desa. Mayoritas desa yang memiliki mata pencaharian tampah bambu dan kuliner tradisional khas Indonesia memiliki sejumlah UMKM unggulan yang sudah berjalan cukup lama. Selain itu, Desa Rancagong memiliki keindahan alam seperti area pesawahan dan mata air yang berpotensi sebagai tempat wisata. Namun permasalahan utama yang dialami Desa Rancagong adalah minimnya infomasi mengenai identitas desa tersebut pada khalayak luas. Hal tersebut disebabkan oleh keterbatasan modal, sumber daya manusia, hingga pengelolaan informasi melalui marketing yang buruk, sehingga berdampak pada kegiatan promosi wisata maupun produk-produk UMKM tidak berjalan dengan baik dan kurang dikenal oleh masyarakat luas. Melalui masalah tersebut, solusi yang dapat diberikan adalah perancangan dan pembuatan video profil desa. Video profil desa merupakan suatu proyek yang penting dalam memperkenalkan dan mempromosikan keunikan desa kepada dunia luar. Video profil dapat membantu meningkatkan kesadaran masyarakat tentang potensi desa dan menarik minat para investor dan wisatawan untuk berkunjung ke desa, selain itu video profil dapat dijadikan sebagai suatu dokumentasi sejarah hingga prestasi yang telah dicapai oleh Desa Rancagong. Agar kualitas video profil desa dapat berlangsung dengan baik, maka dilakukan metode kualitatif melalui survei, wawancara, observasi, studi eksisting dan studi literatur, serta dilakukuan metode perancangan visual secara sistematis melalui berbagai aspek seperti penyusunan script, storyboard,lighting, editingdan lainnya dalam 4 tahapan yaitu riset data, pra produksi, produksi hingga pasca produksi. Harapan besar, melalui perancangan dan pembuatan video profil Desa Rancagong, dapat memperkenalkan dan menambah ketertarikan masyarakat luas dengan meningkatnya kesadaranakan keindahan alam serta beragam potensi produk UMKM yang menarik Desa Rancagong, selain itu dapat pula membantu peningkatan perekonomian dan kesejahteraan masyarakat Desa Rancagong.
MELEJITKAN REBANA GRESIK: OPTIMALISASI PEMASARAN DIGITAL DAN KEMITRAAN STRATEGIS UNTUK PENETRASI PASAR INTERNASIONAL
Authors: Iswoyo Andi , Fauzuddin Yanuar , Muchid Muhamad , Budi Hutomo Setia
Published: January 2025

Program ini bertujuan untuk meningkatkan kapasitas produksi dan omset mitra produsen alat musik rebana di Kabupaten Gresik. Permasalahan mitra adalah kurang optimalnya pemasaran digital dan alat produksi yang belum memenuhi standar Kesehatan dan Keselamatan Kerja (K3). Solusi yang ditawarkan diseminasi TTG penghisap debu, spraybooth, mesin bubut, dan mesin potong meja, penataan layout produksi, pelatihan live selling melalui media sosial dan marketplace, dan kemitraan untuk perluasan pasar ekspor. Metode pelaksanaan program meliputi pelatihan, pendampingan, dan kemitraan strategis dengan pemerintah dan perusahaan lokal dan penetrasi ke pasar internasional. Hasil pelaksanaan program antara lain penataan layout produksi, perancangan dan pengembangan spray booth dan penghisap debu, pengadaan mesin bubut kayu dan mesin potong meja (table saw), pelatihan dan pendampingan live selling melalui media sosial dan marketplace, dan kemitraan dengan Pemerintah Kabupaten Gresik dan beberapa perusahaan di Gresik. Dampak dari program ini antara lain; ada peningkatan keterampilan pekerja dalam pengecatan dan pengamplasan sesuai standar K3 sebesar 70%, ada peningkatan kualitas produk sebesar 40% yang diukur dari kualitas pengecatan, ada peningkatan keterampilan tenaga kerja dalam live selling di sosial media dan marketplace sebesar 60%, ada penambahan penjualan dari aliran live selling 10%, dan ada penetrasi pasar internasional melalui pameran sebanyak dua kali di luar negeri.
Processing sawdust waste into innovative eco-substrate through upskilling Batulappa village women's group
Authors: Dewi Sartika , Asfar Andi Muhammad Irfan Taufan , Asfar Andi Muhamad Iqbal Akbar , Nurannisa Andi , Damayanti Wiwi
Published: January 2025

[Bahasa]: Limbah serbuk gergaji dari hasil pengolahan kayu di Desa Batulappa menimbulkan dampak negatif bagi lingkungan, terutama pencemaran udara akibat pengelolaan yang tidak optimal. Program pengabdian masyarakat ini bertujuan untuk mengatasi permasalahan limbah serbuk gergaji tersebut dengan memberdayakan Kelompok Perempuan Desa Batulappa melalui berupa Upskilling mitra dalam pengolahan limbah serbuk gergaji menjadi Eco-Substrate Innovative. Mitra dalam program ini adalah 15 anggota Kelompok Perempuan Desa Batulappa yang tergabung dalam divisi SDM dan Pengelolaan Lingkungan Hidup. Metode yang digunakan meliputi penyuluhan, pelatihan, dan pendampingan berbasis partisipasi masyarakat (society participatory). Hasil evaluasi menunjukkan peningkatan signifikan, yaitu rata-rata 90% dari aspek pengetahuan dan keterampilan dalam mengolah limbah serbuk gergaji, dimana anggota mitra berhasil memahami dan menguasai teknik pengolahan serbuk gergaji menjadi produk bernilai ekonomis berupa Eco-Substrate Innovative. Selain itu, mitra juga memperoleh keterampilan tambahan, seperti pengemasan, pelabelan, pemasaran, dan pengelolaan keuangan sederhana. Melalui program pengabdian ini, mitra mampu mentransformasi limbah serbuk gergaji menjadi produk inovatif yang ramah lingkungan, sekaligus berpotensi untuk dapat meningkatkan kesejahteraan ekonomi bagi Kelompok Perempuan Desa Batulappa.
Kata Kunci: eco-substrate innovative, fermentasi, media tanam, serbuk gergaji, society participatory
[English]: Sawdust waste from wood processing in Batulappa Village has a negative impact on the environment, especially air pollution due to suboptimal management. This community service program aims to overcome the problem of sawdust waste by empowering the Batulappa Village Women's Group by processing sawdust waste into Innovative Eco-Substrate. The partners in this program were 15 Batulappa Village Women's Group members of the Human Resources and Environmental Management division. The methods used include extension, training, and mentoring based on community participation (society-participatory). The evaluation results show a significant increase, namely an average of 90% in terms of knowledge and skills in processing sawdust waste, where partner members succeeded in understanding and mastering the technique of processing sawdust into economically valuable products in the form of Innovative Eco-Substrate. In addition, partners also gained additional skills, such as packaging, labeling, marketing, and simple financial management. Through this community service program, partners can transform sawdust waste into innovative, environmentally friendly products while also having the potential to improve economic welfare for the Batulappa Village Women's Group.
Keywords: eco-substrate innovative, fermentation, planting media, sawdust, society participatory
ENDÜSTRİ 4.0 UYGULAMALARININ LOJİSTİK SEKTÖRÜNE ETKİSİ: LİTERATÜR TARAMASI
Authors: Şahin Elif , Özdemir Yavuz , Yıldırım Mustafa , Kavak Hakan
Published: January 2025

Endüstri 4.0, en genel tanımıyla, halihazırda işleyen bir süreçten insan faktörünün alınarak yerine makine sistemlerinin konulmasıdır. Burada bahsi geçen insan faktörü, kas gücü demektir. Önem derecesi düşük, bilgi birikimine ihtiyaç duyulmayan işlerin makineler tarafından yapılarak, insan zekasının daha verimli ve faydalı alanlarda kullanılmasını esas alır. Öte yandan lojistik sektörü, hizmet sektörü içerisinde büyük öneme sahip ve gün geçtikçe değerlenen bir sektör haline gelmiştir. Bitmiş ürünün son tüketiciye ulaştırılması ve/veya hammadde, elektrik, enerji ulaşımı gibi konularda hizmet vermektedir. Lojistik sektörü, dinamik bir süreç olması nedeniyle sürekli gelişime muhtaçtır, aksi takdirde yeni dünya rekabetçileri ve artan müşteri istekleri ile baş edemez duruma gelerek sektör dışı kalabilir. Bu durumda Endüstri 4.0, tıpkı diğer sektörleri etkilediği gibi, lojistik sektörünü de etkileyecektir. Araştırmanın amacı, Endüstri 4.0 uygulamalarının lojistik sektörü üzerindeki etkileri ile ilgili kavramsal ve/veya vaka analizi yöntemi kullanılarak yapılmış çalışmaları inceleyerek literatür taraması yapmaktır.
Distribución volumétrica para el aprovechamiento de la energía solar. Caso de estudio en Soria, España
Authors: Fondoso-Ossola Santiago Tomás , Martini Irene , Giancola Emanuela , Soutullo Silvia
Published: January 2025

En el campo de la construcción resulta necesario diseñar edificios teniendo en cuenta el aprovechamiento de la energía solar. Actualmente las herramientas más utilizadas en la disciplina proporcionan resultados cualitativos a partir de la experimentación y no consideran el ensayo de múltiples opciones en etapas proyectuales. El objetivo de este trabajo es facilitar esta labor y brindar un proceso de evaluación basado en la comparación detallada de diversas situaciones. La metodología propuesta consta de 3 etapas (i. Situación actual, ii. Formulación de alternativas y iii. Comparación de resultados) y se apoya en softwares amigables con el usuario y familiarizados con el tema del hábitat construido. Como caso de estudio se adoptó la ampliación de una estructura modular ligera ubicada en Soria (España). El estudio permitió determinar el impacto de las sombras generadas sobre el edificio de interés, lo que proporcionó nuevas bases a las autoridades del proyecto para tomar decisiones.
Estimación del tiempo máximo de permanencia de los equipos de intervención en un incendio: temperatura ambiental.
Authors: Ballesteros-Álvarez J.M. , Romero-Barriuso A. , Villena-Escribano B. M. , Rodríguez-Saiz A.
Published: January 2025

Para poder mejorar los procedimientos de actuación de los equipos de intervención durante un siniestro causado por un incendio, se presenta un modelo mediante la estimación de los tiempos de permanencia a partir de la temperatura ambiental. En la actualidad, la práctica totalidad de los equipos de intervención dispone de cámaras termográficas, que muestran en tiempo real una imagen de la radiación calorífica que está emitiendo un cuerpo, mediante su intensidad de la radiación. A partir de esta temperatura y mediante la aplicación de una ecuación o resolución gráfica, se obtienen los tiempos de permanencia máximos en el área afectada, de forma que se eviten accidentes mortales durante la intervención. Al final, se obtiene que la temperatura máxima admisible en la zona de intervención se sitúa en los 263 °C, siendo el tiempo máximo de permanencia en esas condiciones de 26 segundos.
Dispositivo para el control de grietas en edificios y pruebas de carga y descarga.
Authors: Rodríguez-Rego Jesús M. , Carrasco-Amador Juan P. , Macías-García Antonio , Mendoza-Cerezo Laura , Marcos-Romero Alfonso C.
Published: January 2025

Las grietas estructurales en pilares, vigas y viguetas pueden suponer un enorme riesgo para la integridad de la estructura de un edificio, ya que pueden progresar hasta extenderse por todo su espesor. Por tanto, es necesario realizar un seguimiento para evitar que aumenten los riesgos estructurales y, cuando sea posible, proponer medidas para repararlos. De este modo, aumenta la probabilidad de actuar antes de que se produzca el colapso estructural. Este trabajo ha producido y patentado un dispositivo (ES1293890 U) para la monitorización remota de grietas en edificios y para pruebas de carga, capaz de registrar variaciones milimétricas en grietas y fisuras en edificios para su monitorización detallada [1]. El dispositivo resultante de este trabajo no registró diferencias significativas en los valores recogidos con respecto al comprobador de fisuras y al reloj comparador, por lo que se puede concluir que el dispositivo tiene un gran potencial para su uso en la construcción de edificios, mejorando el estado actual de la técnica.
Exploring the impact of elevated pH and short maceration on the deterioration of red wines: physical and chemical perspectives
Authors: Nascimento Alves Carlos Artur , Camarão Telles Biasoto Aline Camarão Telles , Da Silva Nunes Grace , Oliveira do Nascimento Hélio , Ferreira do Nascimento Ronaldo , Gomes Oliveira Inglides , Coelho de Souza Leão Patrícia , Barros de Vasconcelos Lucicléia
Published: January 2025

This study explored the impact of high pH and short maceration on red wines' physical and chemical traits and stability. Specifically, wines from Petit verdot, Merlot, Malbec and Tempranillo grapes, harvested in a tropical wine-producing region, were analysed. A consistent maceration period of 96 hours was applied in all vinification trials. After six months of bottling, parameters such as colour, acetaldehyde levels, higher alcohols and phenolic compounds were assessed. The findings highlighted significant impacts of grape pH on chemical stability, influenced by the phenolic profile of each grape variety. The short maceration period reduced phenolic compound extraction in high-pH musts, leading to decreased antioxidant potential and chemical stability. Critical indicators included colorimetric parameters, acetaldehyde and free SO₂ content. Acetaldehyde levels were strongly correlated with free SO₂ consumption and colour variations, signifying oxidative processes. Wines with higher concentrations of (+)-catechin, procyanidins and monomeric anthocyanins exhibited enhanced stability, while the presence of hydroxycinnamic acids was associated with oxidative changes. Caffeic acid emerged as a potential marker of oxidative stress, particularly in grapes from warmer climates. To improve the stability of wines made from high-pH grapes, extended maceration times or increased SO₂ dosages may be required.
Implementation of learners’ science process skills by primary school teachers in the Lejweleputswa District of South Africa: A case study
Authors: Bhagwandeen Ritu , Moopeloa Mrs Shirley , Rambuda Awelani Melvin
Published: January 2025

This research explores teachers’ perceptions of the development of learners’ science process skills through the implementation of inquiry-based approaches in Thabong primary schools in the Lejweleputswa District, South Africa. Its aim was to find effective teaching methods using inquiry-based approaches to develop learners’ science process skills and improve their scientific literacy. This quantitative study was conducted with natural sciences and technology, natural sciences, and mathematics teachers, and data was analysed using SPSS 27. The results showed a statistically significant relationship between inquiry-based approaches and learners’ acquisition of science process skills. Although teachers understood the advantages of using inquiry-based teaching, there were many obstructions to the implementation of this in classrooms in the schools used in this study.
Using Lesson Study as a tool to cope with instructional challenges: A case study of Chemistry teachers in Nigeria
Authors: Moju Monday , Fashakin Olusegun
Published: January 2025

Educators encounter many obstacles in effectively planning and teaching students in the classroom. One of the most significant challenges is the constraints imposed by curriculum standards, which can hinder teachers from customizing lesson plans that reflect students' current situations. To address this issue, a research study was conducted to investigate how collaborative professional development using lesson study could support teachers in managing lesson planning and teaching issues in schools. Two chemistry teachers in Educational District IV Lagos State, Nigeria, participated in the lesson study process, were interviewed, and engaged in writing a reflection. The data gathered were transcribed, coded, analyzed, and the results revealed that chemistry teachers face difficulties due to curriculum standards and expectations of national and external examinations. Nevertheless, through lesson study, the teachers recognized the necessity of prioritizing students' needs while designing lesson plans to overcome challenges and make chemistry relevant to students.
Analyzing trends and suggested instructional strategies for Geometry education: Insights from Uganda Certificate of Education-Mathematics Examinations, 2016-2022
Authors: Ndungo Issa , Akugizibwe Edwin , Balimuttajjo Sudi
Published: January 2025

Geometry education plays a pivotal role in fostering analytical, spatial, and problem-solving skills among students. Nonetheless, there is still a problem with how well geometry training in Ugandan schools accomplishes these objectives and this is evident in the Uganda Certificate of Education (UCE) examinations. To close this gap, a comprehensive examination of data taken from Uganda National Examinations Board (UNEB) reports covering the years 2016 to 2022 was carried out; with an emphasis on candidates’ performance, the study looks at common geometric ideas, pinpoints areas of weakness for candidates, and assesses response quality. This study's content analysis reveals notable variations in the quality of responses to various mathematics areas, with geometry consistently having the largest percentage of poor responses. Interestingly, in most areas, attempt levels positively correlate with response quality; but, in the case of geometry, this correlation reverses, suggesting that learners in this domain confront different problems. These problems include using geometric principles for problem-solving, combining algebraic and geometric concepts, and spatial visualization. The study advocates for using technology, active and problem-based learning; as these approaches provide opportunities for experiential learning, and conceptual knowledge reinforcement to learners.  All this will support ongoing attempts to enhance mathematics education, particularly in the field of geometry, within the Ugandan context.
Unlocking insights: A systematic review of contextualized cubing instructional strategies
Authors: Ramaila Sam
Published: January 2025

This systematic review examines the effectiveness of contextualized instructional strategies in the domain of cubing. Cubing, a popular puzzle-solving activity, has garnered significant attention in educational settings as a tool for enhancing spatial reasoning and problem-solving skills. However, the efficacy of different instructional approaches in facilitating cubing mastery remains underexplored. Through a comprehensive analysis of existing literature, this review synthesizes evidence on the impact of contextualized instructional strategies on learners' cubing proficiency. Drawing from a range of studies, including experimental interventions, comparative analyses, and qualitative investigations, key themes emerged regarding the benefits of contextualized instruction in enhancing learners' understanding of cubing algorithms, spatial visualization abilities, and overall problem-solving competence. Additionally, this review identifies gaps in the current literature and offers insights for future research directions, highlighting the importance of tailored instructional approaches that integrate real-world contexts to optimize cubing learning outcomes. Overall, this study provides valuable insights for educators, researchers, and practitioners seeking to enhance cubing instruction through evidence-based pedagogical strategies.
Evaluación de la resistencia antibacteriana de Salmonella enterica aisladas de aves de combate de un galpón del distrito de Carabayllo en el año 2021
Authors:   , Lossio Espejo Andrea Mirella
Published: January 2025

El objetivo del presente estudio fue evaluar la resistencia antibacteriana de Salmonella enterica aisladadas de la cloaca de aves de pelea. Se tomaron 135 muestras cloacales mediante hisopado en aves de pelea de un galpón en el distrito de Carabayllo, en el año 2021, de lo cual se logró aislar 3 colonias de Salmonella enterica representando el 2.2% (IC95%: 0 – 4.71%) del total de muestras. Siendo el enriquecimiento tardío en caldo Rappaport-Vassiliadis más eficiente en el aislamiento de esta bacteria estudiada. Una vez identificadas las colonias, utilizamos el método Kirby Bauer para determinar la sensibilidad microbiana, donde se enfrentaron a 16 antibióticos, obteniendo como resultado que el 100% (3/3) de las colonias fueron resistentes a eritromicina, penicilina, clindamicina y estreptomicina, el 66.67% (2/3) fueron resistentes a oxitetracilina, ampicilina y doxicilina, mientras que todas las colonias son sensibles a levofloxacina, ceftazidime, ceftriaxona, enrofloxacina, ofloxacina, ciprofloxacina, cefatoxime y gentamicina.
Infarto de miocardio con elevación del segmento ST en pacientes menores de 45 años: análisis descriptivo de dos cohortes peruanas
Authors:   , Azaña Flores Adela Milagros , Cuya Vivanco Rosmery Lisbeth
Published: January 2025

Objetivos: Describir las características clínicas y la mortalidad, principales complicaciones y eventos intrahospitalarios asociados a pacientes adultos menores de 45 años con infarto de miocardio con elevación del segmento ST (IMCEST). Materiales y métodos: Estudio descriptivo de los datos secundarios de dos cohortes (PERSTEMI I y II). PERSTEMI I analizó casos de IMCEST del 2016 en veinte hospitales, mientras que PERSTEMI II se centró en pacientes con IMCEST tratados en el 2020. Resultados: Se incluyeron 53 pacientes menores de 45 años con IMCEST, predominantemente de sexo masculino (94,3%). Los factores de riesgo más comunes fueron la dislipidemia (32,1%) e hipertensión (24,4%). El dolor anginoso fue la manifestación inicial en el 88,7% y el estado clínico de ingreso en el 50,9% de los casos fue Killip Kimbal II. Todos los pacientes presentaban ritmo sinusal y la localización más frecuente del infarto fue anteroseptal e inferior (24,5%). El 75,5% recibió terapia de reperfusión, siendo el ICPp el principal tratamiento (46,7%). El éxito se informó en el 65% de los casos. La estancia hospitalaria promedio fue de 7 días, con el uso generalizado de aspirinas y estatinas (100%). La mortalidad hospitalaria fue del 5,7% en los pacientes estudiados. Conclusiones: El estudio sugiere que el IMCEST es más común en hombres, con factores de riesgo como dislipidemia e hipertensión. El tratamiento de reperfusión más utilizado fue el intervencionismo coronario primario y el evento intrahospitalario más encontrado fue la falla cardiaca. Estos hallazgos son importantes para adoptar medidas de prevención y tener una estrategia del manejo de IMCEST a nivel nacional. Se requieren estudios adicionales para confirmar y ampliar estos hallazgos.
Refugio temporal: estrategias de arquitectura terapéutica para la atención de casos de violencia intrafamiliar en San Juan de Lurigancho, Lima 2021
Authors:   , Escalante Arriola Gladys , Valencia Mestanza Georgette Jassel
Published: January 2025

La tesis determina las principales estrategias de arquitectura terapéutica que coadyuvan a la atención de víctimas de violencia intrafamiliar en refugios temporales en Perú, cuya problemática social ha ido en ascenso contrastando con la insuficiencia en equipamiento arquitectónico que abastezca dicha demanda y al escaso desarrollo de estudios sobre los efectos de la arquitectura terapéutica en las personas. Para ello, se han realizado entrevistas estructuradas y semiestructuradas a especialistas del Programa Nacional en conjunto de una exhaustiva búsqueda de información con base en evidencia científica, resultando en tres tablas con criterios de diseño que despliegan estrategias de arquitectura terapéutica: la primera muestra todos los lineamientos determinados tras el análisis de toda la información; la segunda filtra y presenta solo los principales criterios con sus respectivas estrategias para aplicar en refugios destinados a casos de violencia intrafamiliar; y la tercera genera criterios adicionales que complementan las dos primeras tablas, basados en el desarrollo del anteproyecto arquitectónico dentro del contexto peruano. Estas estrategias conforman criterios de diseño los cuales se dividen en tres dimensiones: flexibilidad, el cual contempla criterios de forma, plata libre, modulación, partición y adaptabilidad; diseño terapéutico que integra criterios de ubicación, privacidad, jerarquía, integración, apertura a espacios al aire libre, vegetación, visuales a áreas verdes, efectos de luz, iluminación, confort térmico, control acústico, color, texturas y materialidad, entre otros; y por último accesibilidad que incluye criterios de amplitud, orientación, señalética, elementos de apoyo, desplazamiento y transitabilidad; concluyendo así en un conjunto de principales estrategias a considerar en el diseño de refugios temporales para la atención de víctimas de violencia intrafamiliar en el Perú.
Perfil fitoquímico y potencial antibacteriano del extracto alcohólico derivado del propóleo peruano contra Enterococcus faecalis
Authors:   , Espinoza Salas Pamela Leonor , Munsibay Foronda Andrea Yolanda
Published: January 2025

Este estudio tuvo como objetivo obtener un extracto alcohólico de propóleo (PAE), analizar su perfil fitoquímico y probar su actividad antibacteriana contra Enterococcus faecalis para demostrar su uso potencial en tratamientos pulpares para dientes primarios. El PAE fue obtenido mediante maceración con alcohol absoluto. El ensayo de solubilidad y el perfil fitoquímico fueron realizados. Los compuestos fenólicos y flavonoides fueron cuantificados mediante métodos de espectrofotometría. La actividad antibacteriana de PAE se evaluó mediante la concentración mínima inhibitoria (MIC) y concentración mínima bactericida (CMB) contra E. faecalis. Dos pastas experimentales intracanal a base de propóleo con propilenglicol fueron fabricados y comparados con la pasta triple antibiótica mediante el método de difusión en pozos de agar contra E. faecalis. Se analizaron los resultados utilizando la prueba de Kruskal-Wallis (α=0.05). La prueba de solubilidad mostró que el etanol era el mejor disolvente para PAE. El perfil fitoquímico indicó que PAE contiene taninos, alcaloides, flavonoides, antocianidinas, aldehídos, glucósidos, cetonas, triterpenoides, esteroides y catequinas. El contenido de compuestos fenólicos y flavonoides fue de 49,8 ± 0,13 mg/ml equivalente de ácido gálico (EAG) y 0,824 ± 0,03 mg/ml equivalente de quercetina (EQ), respectivamente. Los resultados del PAE fueron observados mediante el MIC y MBC con valores de 60 mg/ml y 130 mg/ml, exhibiendo actividad antibacteriana contra E. faecalis. El ensayo de difusión en pozo de agar demostró que la pasta a base de propóleo tiene actividad antibacteriana. Sin embargo, la pasta triple antibiótica mostró una actividad antibacteriana superior contra E. faecalis. Los resultados indicaron que PAE tiene un alto contenido de compuestos fenólicos y flavonoides con actividad antibacteriana contra E. faecalis.
Covid-19 como factor asociado a preeclampsia en gestantes atendidas en el Hospital Nacional Docente Madre Niño San Bartolomé septiembre 2020 – agosto 2021
Authors:   , Melchor Gallardo Carlos Alessandro , Asencios Chacon Aurea Brissa Maciel
Published: January 2025

Objetivo: Determinar la asociación entre preeclampsia y COVID-19 en un hospital de tercer nivel en Perú. Materiales y métodos: Estudio observacional transversal analítico realizado en gestantes atendidas por parto entre septiembre del 2020 y agosto del 2021 en un hospital especializado en atención obstétrica. Se realizó la recolección de variables clínicas y obstétricas. En el análisis estadístico, las variables fueron reportadas mediante frecuencias absolutas y relativas; para la evaluación de la relación entre variables se empleó la prueba de Chi Cuadrado considerando un intervalo de confianza al 95% (IC95%). Resultados: Se incluyeron 263 gestantes, 25,5% con diagnóstico de COVID-19. El 13,6% presentó preeclampsia. No hubo diferencia estadística significativa respecto a preeclampsia entre el grupo COVID-19 y no COVID-19. Conclusiones: No se encontró asociación estadística entre preeclampsia y COVID-19.
Frecuencia de la resistencia de Escherichia coli a antimicrobianos y sus factores de riesgo en perros de dos clínicas veterinarias de Lima, Perú
Authors:   , Ventura Valencia Cristina Margot
Published: January 2025

Antecedentes Los sistemas de vigilancia de la resistencia a los antimicrobianos (RAM) en animales de compañía son escasos, especialmente en los países de ingresos medios-bajos. En Perú, la información sobre RAM en perros es limitada. Por ello, el objetivo del presente estudio fue establecer los niveles de RAM y sus factores asociados en perros clínicamente sanos atendidos en dos clínicas veterinarias de distritos socioeconómicos diferentes de Lima (Perú). Métodos Se incluyeron noventa perros en el estudio y se analizaron sus muestras fecales para detectar la presencia de Escherichia coli. Además, se evaluó la resistencia antimicrobiana de las muestras positivas de E. coli mediante el método de difusión en disco y se usó microdilución para determinar la susceptibilidad a colistina. Se caracterizó molecularmente los aislados que dieron positivo para β-lactamasas de espectro extendido (BLEE) y resistentes a la colistina. Se evaluaron las relaciones clonales de los aislados mediante electroforesis en gel de campo pulsado. Por último, se analizaron estadísticamente los factores asociados a la resistencia a los antimicrobianos. Resultados Se detectaron 35 (38,9%) aislados de E. coli a partir de 90 muestras de hisopados rectales de perros. Se detectaron niveles elevados de resistencia a la ampicilina (57,1%), ácido nalidíxico (54,3%), tetraciclina (48,6%) y azitromicina (25,7%). Los niveles de resistencia a las cefalosporinas fueron ≥ 20% y 14,3% para la colistina. Se detectaron aislados productores de BLEE en 12 (34,2%) aislados; específicamente, 6 blaCTX-M-55 (50,0%), dos (16,6%) blaCTX-M-15, y dos (16,6%) blaCTX-M-8-like. Se observaron sustituciones de codones de aminoácidos en el gen mgrB (V8A) y mutaciones en el promotor de mgrB (a12g, g98t y c89t) relacionados con la resistencia a colistina en E. coli resistentes. Se observó que los aislados resistentes a la colistina mostraban una filogenia diversa, no mostrando una relación clonal. Además, se observaron asociaciones entre la edad…
Estilos de aprendizaje y rendimiento académico en entornos virtuales en alumnos de portugués de una universidad peruana, en 2020 y 2021
Authors:   , Castañeda Farro Brisaida Maria Alejandra , Metz Pereira Mariane
Published: January 2025

Este trabajo pretende analizar la relación entre el rendimiento académico y estilos de aprendizaje de estudiantes de portugués de una universidad peruana. El estudio se llevó a cabo desde marzo 2020 hasta diciembre 2021, aplicando virtualmente el Cuestionario de Honey y Alonso de Estilos de Aprendizaje (CHAEA) a 142 estudiantes. Asimismo, se emplearon los registros de calificaciones para documentar el rendimiento académico. El análisis estadístico, realizado con el programa SPSS versión 28.0.0.0., determinó que el rendimiento académico no presentó una relación significativa con los estilos de aprendizaje. El estudio concluye que el estilo de aprendizaje de los estudiantes del curso de portugués no influye en su rendimiento académico; sin embargo, presentan mayor afinidad con las situaciones estructurales con finalidad clara, debates y actividades grupales que se generan durante la enseñanza de este idioma.
Spatio-temporal analysis of wetland loss in the lower Mekong River Basin based on surface water detection datasets and machine learning
Authors: Hiraga Yusuke , Aoki Mayu , Kazama So
Published: January 2025

Wetland loss and degradation is a major global issue in which its detailed estimation of spatio-temporal distribution will be a key for understanding the dynamics and subsequent impact assessment studies. This study aimed to estimate the spatio-temporal distributions of wetland loss, analyze its geographical characteristics, and quantify the likelihood of loss occurrence for existing wetlands in the lower Mekong River Basin in Cambodia. Using the global surface water detection datasets, the spatiotemporal distribution of wetland loss with high resolution (30m) over the entire study area (140km×210km) during 1984–2021 was estimated. Statistically significant differences were found in the distance from urban areas and distance from river channels for the existing wetlands and lost wetlands as of 2021, in which the lost wetlands tend to locate closer to urban areas. Subsequent Land Use/Land Cover after the wetland loss was found to be mainly croplands (72.2%) in the study area. Though our estimate overall agrees with the recent global-scale estimate, our estimate resulted in notable ratio of rangelands (11.3%), which represents the unique characteristics of floodplain wetlands in the lower Mekong River Basin. The Random Forest and Light GBM algorithms-based wetland loss prediction models resulted in good statistical evaluation metrics. In both models, the distance from river channels was found to be the most important feature for classifying existing wetlands and lost wetlands. Application of the developed models successfully provided the map of likelihood of wetland loss for existing wetlands in the study area.
ATAC-seq Guided Interpretable Machine Learning Reveals Cancer-Specific Chromatin Features in Cell-free DNA
Authors: Gunarathna Sakuntha , Nagornyuk Aerica , Belabbaci Nazim , Nguyen Regina , Ganai Sabha , Lemke Tabatha , Garry Cassy , Saotome Mika , Wang Xusheng , Takaku Motoki
Published: January 2025

Cell-free DNAs (cfDNAs) are DNA fragments found in blood. In healthy individuals, cfDNAs are primarily derived from immune cells, while in cancer patients, a significant fraction of cfDNAs originates from cancerous cells. These cancer-derived cfDNAs contain specific mutations, making cfDNA analysis a promising diagnostic biomarker. Recent studies have revealed that epigenetic information, such as DNA methylation and nucleosome positioning, is retained in cfDNAs, enhancing the accuracy of cell-of-origin predictions. This study aims to characterize the chromatin architecture preserved in cfDNAs by looking at nucleosomal DNA enrichment. Nucleosome fragments from both breast and pancreatic cancer patients are significantly enriched in open chromatin regions. A differential enrichment was observed between healthy donors and cancer patients at cell type-specific ATAC-seq peaks. Leveraging this pattern of open chromatin enrichment, we enhanced the prediction accuracy for identifying breast cancer-derived cfDNA through machine learning. Our analysis pipeline provides an interpretable machine learning platform that effectively detects cancer-specific nucleosome enrichment in cfDNAs.
Proteomics-based aging clocks in midlife and late-life and risk of dementia
Authors: Sedaghat Sanaz , Park Saeun , Walker Rob , Wang Shuo , Liu Jialing , Hughes Timothy , Sabayan Behnam , Tang Weihong , Coresh Josef , Pankow James , Walker Keenan , Casanova Ramon , Dubin Ruth , Deo Rajat , Rotter Jerome , Wood Alexis , Ganz Peter , Lutsey Pamela , Guan Weihua , Prizment Anna
Published: January 2025

Background: Biological age can be quantified by composite proteomic scores, called aging clocks. We investigated whether biological age acceleration (a discrepancy between chronological and biological age) in midlife and late-life is associated with cognitive function and risk of dementia.
Methods: We used two population-based cohort studies: Atherosclerosis Risk in Communities (ARIC) Study and Multi-Ethnic Study of Atherosclerosis (MESA). Proteomics-based aging clocks (PACs) were created in ARIC at midlife (mean age: 58 years, n=11,758) and late-life (mean age: 77 years, n=4,934) using elastic net regression models in two-thirds of dementia-free participants and validated in the remaining one-third of participants. Age acceleration (AA) was calculated as residuals after regressing PACs on chronological age. We validated the midlife PAC in the MESA cohort (mean age: 62 years, n=5,829). We used multivariable linear and Cox proportional hazards regression to assess the association of AA with cognitive function and dementia incidence, respectively.
Results: In ARIC, every five years AA was associated with lower global cognitive function: difference: -0.11, 95% confidence interval (CI): -0.16, -0.06) using midlife AA and difference: -0.17, CI: -0.23, -0.12 using late-life AA. Consistently, midlife AA was associated with higher risk of dementia (hazard ratio [HR]: 1.20 [CI: 1.04, 1.36]) and more prominently when using late-life AA (HR: 2.14 [CI:1.67, 2.73]). Similar findings were observed in the MESA study: every five years AA was associated with lower global cognitive function (difference: -0.08 [CI: -0.14, -0.03]) and higher risk of dementia (HR:1.23 [CI: 1.04, 1.46]).
Conclusion: Accelerated biological age – as defined by the plasma proteome – is associated with lower cognitive function and predicts a higher risk of dementia in midlife and more prominently in late-life.
Photobiomodulation with 650 nm Wavelength Mediates Endoplasmic Reticulum-Mitochondria Contact and Ameliorates Lipotoxicity in NAFLD via Mfn2/PERK/CHOP Signaling
Authors: Yao Min , Jiang Zhixuan , Wu Shan , Zhou Shengzhe , Zheng Hongjie , Bai Yubing , Zhang Yiqiu
Published: January 2025

The disruption of mitochondria associated membranes (MAMs) is involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) by modulating endoplasmic reticulum stress (ERS) and mitochondrial malfunction induced by lipotoxicity. Photobiomodulation (PBM), as a non-invasive physical therapy, has been demonstrated to improve cellular metabolim in various diseases. Here we found that PBM with 650 nm ameliorated lipid accumulation and liver injury in high-fat-diet-fed mice. Moreover, MAMs integrity was restored in liver tissues of NAFLD after PBM. Correspondingly, PBM enhanced mitochondria-ER colocalization and improved mitochondrial homeostasis in fatty-acid-treated HepG2 cells. Mechanically, Mfn2 expression was selectively elevated by PBM, accompanied by downregulation of PERK, p-PERK, and CHOP. The beneficial effects of PBM were diminished by Mfn2 knockdown, while PERK activity regulated mitochondrial function without altering MAMs formation. Thus, PBM relieves lipotoxicity in NAFLD by enhancing MAMs integrity via the Mfn2/PERK/CHOP pathway. Our findings may provide evidence for noninvasive physical light therapeutics for lifestyle-related metabolic diseases.
Current carbon policies and emerging emission control technologies in the dairy supply chain
Authors: Wang Bei , Meng Fanyu , Wang Weijun , Wang Guofeng , Sun Chuanwang , Yang Zhijie , Wang Yadong , Han Haoying , Meng Yi , He Jian , Wang Yanbo , Liao Maolin , Wu Bobo , Sun Baoguo
Published: January 2025

Addressing the dynamic changes in the carbon footprint (CF) of the dairy industry to meet the diverse demands of different countries and achieve the global net-zero emission target presents a significant challenge. This study integrates a systematic scoping of CF and reduction strategies, with a policy analysis utilizing Term Frequency–Inverse Document Frequency (TF-IDF) statistics to provide a comprehensive assessment of current efforts to mitigate CF in the dairy industry. Across 29 countries, the CF of dairy production ranges from 0.57 kg CO₂-eq/kg FPCM (Norway) to 5.85 kg CO₂-eq/kg FPCM (Tanzania). Mitigation strategies are implemented across the entire dairy supply chain, with a primary focus on the milk production stage. Among the six countries analyzed over a 10-year period, New Zealand demonstrated the highest policy effectiveness, largely due to measures targeting feeding practices and dairy cattle breeding. This article offers an in-depth evaluation of CF reduction in the dairy sector, integrating environmental, technological, and policy dimensions.
Octadecanoids as emerging lipid mediators in cnidarian-dinoflagellate symbiosis
Authors: wheelock craig , Botana Marina , Lewis Robert , Quaranta Alessandro , Salamin Olivier , Revol-Cavalier Johanna , Oakley Clint , Feussner Ivo , Hamberg Mats , Grossman Arthur , Suggett David , Weis Virginia , Davy Simon
Published: January 2025

Oxylipin signaling has been suggested as a potential mechanism for the inter-partner recognition and homeostasis regulation of cnidarian-dinoflagellate symbiosis, which maintains the ecological viability of coral reefs. Here we assessed the effects of symbiosis and symbiont identity on a model cnidarian, the sea anemone Exaiptasia diaphana, using mass spectrometry to quantify octadecanoid oxylipins (i.e., 18-carbon-derived oxygenated fatty acids). A total of 84 octadecanoids were reported, and distinct stereospecificity was observed for the synthesis of R- and S-enantiomers for symbiont-free anemones and free-living cultured dinoflagellate symbionts, respectively. Symbiont-derived 13(S)-hydroxy-octadecatetraenoic acid (13(S)-HOTE) linked to a 13(S)-lipoxygenase was translocated to the host anemone with a 32-fold increase, suggesting it as a biomarker of symbiosis and as a potential agonist of host receptors that regulate inflammatory transcription. Only symbiosis with the native symbiont Breviolum minutum decreased the abundance of pro-inflammatory 9(R)-hydroxy-octadecadienoic acid (9(R)-HODE) in the host. In contrast, symbiosis with the non-native symbiont Durusdinium trenchii was marked by higher abundance of autoxidation-derived octadecanoids, corroborating previous evidence for cellular stress in this association. The putative octadecanoid signaling pathways reported here suggest foundational knowledge gaps that can support the bioengineering and selective breeding of more optimal host-symbiont pairings to enhance resilience and survival of coral reefs.
Development and Iodine Testing of a Novel C12A7 Electride Planar Hollow Cathode
Authors: Becke Philipp S. , Kottke Nils Gerrit , Vaupel Max , Kutufa Niccola , Wätzig Katja , Tajmar Martin , Hey Franz Georg
Published: January 2025

Iodine exhibits promising characteristics as a propellant for electric propulsion (EP) systems. Its performance is comparable to xenon, yet it offers significant cost advantages. Moreover, it can be stored in a compact solid state and easily fed into the system through sublimation. Thruster operation has already been successfully demonstrated for the iodine fed Advanced Cusp Field Thruster, Hall Effect Thrusters and Radiofrequency Ion Thrusters (RIT), with the first in-space demonstration for an iodine RIT in early 2021. However, an iodine-fed plasma-bridged hot neutraliser is required to unlock the full systemic potential of an iodine EP subsystem at higher current levels. There exists no high-current iodine-fed neutraliser so far, as the corrosive nature of iodine and the potential for emitter material poisoning pose challenges. In the framework of the “IcoN” activity, a planar hollow cathode based on a C12A7 electride emitter has been developed and tested. The emitter has been manufactured by Fraunhofer IKTS, the neutraliser was manufactured and tested at Airbus Friedrichshafen. The initial testing was done with krypton and changed to iodine, as soon as a reliable cathode performance was achieved. After the first iodine tests were completed, the feed system was updated with a proportional valve to allow better control of the flow rate. In the final test series, two different emitter types and two planar cathode configurations have been tested with iodine. The longest achieved stable discharge was 26 minutes. While it was possible to develop a fully functional iodine feed system and a novel heaterless planar cathode based on C12A7 electride for krypton, no long-time stable iodine discharge was achievable in the frame of the project.
Recurrent horizontal gene acquisition in the evolutionary history of ants
Authors: Schrader Lukas , Rinke Janina , He Ding , Vizueta Joel , Larsen Rasmus , Xiong Zijun , Gadau Jürgen , Zhang Guojie , Boomsma Jacobus
Published: January 2025

Horizontal Gene transfer (HGT) from bacteria has often led to Horizontal Gene Acquisition (HGA), subsequently contributing to phenotypic innovation. Ants are interesting potential targets for HGA because they host many mutualistic associations with vertically transmitted symbionts, but the overall prevalence of HGA across the ants and other insect lineages remains virtually unexplored. Here, we systematically screened the genomes of 163 ant species and identified 497 HGA events of protein-coding genes, predominantly derived from intracellular symbionts, in 85 species belonging to eight subfamilies. Apart from convergent horizontal transfers of Wolbachia-derived ankyrin repeat proteins into the genomes of 45 ant species, we identified dozens of other HGAs that likely offered adaptive innovations of phenotypic functions, primarily mediating immune-system adaptations or facilitating nutritional niche expansions. We provide in-depth characterizations of multiple clade- and species-specific HGAs, some as old as 40 MY, consistent with strong evolutionary conservation. Our study is the first of its kind in ants and considerably expands our general appreciation of the
evolutionary significance of HGA from bacteria to eukaryotes.
STARGATE: An Undergraduate Experimental Electric Propulsion Student Research Project
Authors: Blue Claude , Calhoun Sydney , Shiffer Christopher , Milivojevic Noah
Published: January 2025

This paper reports on the ongoing investigation regarding the feasibility of utilizing the Corona Discharge Reaction as an alternative plasma production mechanism in a Gridded Ion Thruster system. The STARGATE project investigated and demonstrated the difference between negative and positive Corona Discharge Reactions as it pertains to electric propulsion applications, as well as investigated the feasibility of utilizing the Corona Discharge Reaction for plasma production in its intended operating environment. The team has designed and fabricated an initial functional vacuum testing prototype, and is pending initial test-firing.
Analysis of Lymph Node Metastasis and Risk Factors in 424 Patients with low-grade endometrioid carcinoma
Authors: Cao Lina , Lu Xiaoyuan , Wang Yijun , Wang Luyao
Published: January 2025

Purpose: To explore the lymph node metastasis (LNM) of low-grade endometrioid carcinoma (EEC) and its related risk factors, and to analyze the efficacy of related risk factors in predicting LNM.
Methods: Data of 424 EEC patients who underwent endometrial cancer staging surgery from January 2019 to June 2024 were retrospectively analyzed. Univariate and multivariate logistic regression were used to analyze the related factors of LNM. The receiver operating characteristic (ROC) curve was drawn to analyze the efficacy of related independent risk factors in predicting LNM.
Results: The rate of LNM was 7.8% (33/424). Univariate analysis showed that histological grade, tumor size, depth of myometrial, cervical stromal, lymphovascular space invasion (LVSI), microcystic, elongated, fragmented (MELF), carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199)and human epididymis protein 4 (HE4) were associated with LNM of EEC. Logistic regression analysis showed that LVSI, MELF, depth of myometria and CA125were independent risk factors for LNM. The ROC curve area of CA125 and depth of myometria was 0.796 and 0.734. The best cut-off point of CA125 was 31.36 (U/mL), corresponding to the largest Youden index of 53.9%, and its positive likelihood ratio was 5.2. The accuracy of diagnosing LNM by combining CA125 and depth of myometrial is higher than that of either alone.
Conclusions: LNM is more likely to occur when there are risk factors such as LVSI positive, MELF invasion pattern, myometrial invasion depth ≥50% and CA125. The accuracy of CA125 combined with depth of myometrial in the diagnosis of LNM is higher than that of either alone. This study has a certain reference value for predicting the risk of LNM and stratified management and treatment for EEC patients.