bluuebunny/crossref_metadata_2025 huggingface dataset:
Rationale and design of healthy at home for COPD: an integrated remote patient monitoring and virtual pulmonary rehabilitation pilot study
Authors: O’Connor Laurel , Behar Stephanie , Tarrant Seanan , Stamegna Pamela , Pretz Caitlin , Wang Biqi , Savage Brandon , Scornavacca Thomas Thomas , Shirshac Jeanne , Wilkie Tracey , Hyder Michael , Zai Adrian , Toomey Shaun , Mullen Marie , Fisher Kimberly , Tigas Emil , Wong Steven , McManus David D. , Alper Eric , Lindenauer Peter K. , Dickson Eric , Broach John , Kheterpal Vik , Soni Apurv
Published: October 2024

Chronic obstructive pulmonary disease (COPD) is a common, costly, and morbid condition. Pulmonary rehabilitation, close monitoring, and early intervention during acute exacerbations of symptoms represent a comprehensive approach to improve outcomes, but the optimal means of delivering these services is uncertain. Logistical, financial, and social barriers to providing healthcare through face-to-face encounters, paired with recent developments in technology, have stimulated interest in exploring alternative models of care. The Healthy at Home study seeks to determine the feasibility of a multimodal, digitally enhanced intervention provided to participants with COPD longitudinally over 6 months. This paper details the recruitment, methods, and analysis plan for the study, which is recruiting 100 participants in its pilot phase. Participants were provided with several integrated services including a smartwatch to track physiological data, a study app to track symptoms and study instruments, access to a mobile integrated health program for acute clinical needs, and a virtual comprehensive pulmonary support service. Participants shared physiologic, demographic, and symptom reports, electronic health records, and claims data with the study team, facilitating a better understanding of their symptoms and potential care needs longitudinally. The Healthy at Home study seeks to develop a comprehensive digital phenotype of COPD by tracking and responding to multiple indices of disease behavior and facilitating early and nuanced responses to changes in participants’ health status. This study is registered at Clinicaltrials.gov (NCT06000696).
Academic Neurosurgery Gender and Authorship Trends in the United States
Authors: Kearns Kathryn N. , Kurker Kristina P. , Marino Alexandria C. , Zhao Patricia , Ramanathan Purushotham , Shaffrey Mark E. , Jane John A. , Park Min S.
Published: October 2024

BACKGROUND AND OBJECTIVES:

Women represent ∼20% of the national neurosurgical resident cohort but only ∼10% of academic neurosurgeons in the United States. Recognizing that the publication of scientific literature contributes to academic advancement, we measured authorship trends of academic neurosurgeons to query publication differences as an explanation for the discrepancy of female representation in academic positions.

METHODS:

Physician data were obtained from program and individual physician webpages. Annual total, first author, and senior author publications were recorded for each neurosurgeon from 1980 to 2020. Mean publication number as a function of the year relative to residency graduation was calculated for all, first author, and senior author publications for all timepoints with >50 individuals. The mean first years of publication were compared using unpaired 2-tailed t-tests. The slope of publication for the senior author and all publications was calculated using individual best-fit lines from years 0 to 10 relative to residency graduation.

RESULTS:

Overall, 1601 faculty members were evaluated (female = 167 [10.4%], male = 1434 [89.6%]). First-author publication for female members peaked at 0.60 publications/year, and for male members at 0.80 publications/year, both at −1 year from graduation (P = .038). Female first publication occurred earlier (−2.4 vs 1.45 years; P < .00001). The mean increase in all publications/year from years 0 to 10 was 0.25 for women and 0.28 for men (P = .68). The increase in senior publications/year was 0.11 for women and 0.13 for men (P = .39). The ratio of total publications to the Scopus h-index was 3.08 for women and 3.62 for men (P = .07).

CONCLUSION:

These data suggest that women publish earlier but have fewer first-author publications at −1 year, the timepoint of peak publication for both genders. There was no significant gender difference in rates of the first author and all publications over the years 0 to 10. The ratio of publications to the h-index did not differ significantly but showed a trend suggesting that women produce higher-impact articles and may need fewer publications to achieve the same change in the h-index.
Natural Way Of Boosting Immunity: The Role of Echinacea in Cold Prevention and Treatment - A Literature Review
Authors: Zygmunt Anna Ewa , Karoń Łukasz , Karoń Karolina , Grabowski Wojciech , Pedrycz Daria , Drapała Grzegorz , Pedrycz Emilia
Published: October 2024

Echinacea, a widely used herbal remedy derived from the purple coneflower, is renowned for its potential benefits in treating and preventing the common cold. This review examines Echinacea’s role in managing cold symptoms, its mechanisms of action, and its efficacy across various species and preparations. Echinacea species, particularly Echinacea purpurea, Echinacea angustifolia, and Echinacea pallida, contain active compounds such as alkamides, caffeic acid derivatives, polysaccharides, and glycoproteins, which contribute to its immunomodulatory, anti-inflammatory, and antiviral properties. Clinical studies demonstrate that Echinacea can modestly reduce the incidence, duration, and severity of colds, though results are variable due to differences in preparation forms (e.g., teas, tinctures, extracts) and study methodologies. Proprietary extracts like Echinaforce® have shown consistent benefits, while other formulations have yielded mixed results. Despite a generally favorable safety profile, including mild gastrointestinal disturbances and rare allergic reactions, the long-term safety, particularly in vulnerable populations, remains under-researched. Future research should focus on standardized formulations, detailed molecular mechanisms, and rigorous clinical trials to better define Echinacea’s role in cold management. Overall, while Echinacea offers a promising option for cold prevention and treatment, its use should be informed by evidence-based practices considering formulation, dosage, and individual patient factors.
New Insights on the Turin Shroud’s Body Image: Face Image at Different Wavelengths and its Double Superficiality
Authors: De Caro Liberato , Fanti Giulio
Published: October 2024

Various images of the face of the Turin Shroud Man, acquired at different wavelengths, from the near infrared region to the ultraviolet, have been studied and compared. A correlation as a function of the wavelength, between the penetration depth in the fabric of the incident light and the anatomic details visible on the images, is discussed based on the physical properties of linen threads and light. In addition, the backside of the Turin Shroud, in correspondence of the region of the face, has been examined, evidencing the possible presence of a second superficial image impressed on the backside. Notwithstanding the high level of scientific knowledge today reached, there is no known physical/chemical process which allows to explain all the properties of the Turin Shroud’s body image. According to our scientific knowledge, the corpse of a dead man cannot produce an energy capable to imprint on a linen cloth an image with all the microscopical and macroscopical properties discovered by analyzing the body image of the Turin Shroud, which has not yet been reproduced in any laboratory in the world. According to faith the corpse of a living Man can do it, during the resurrection, assuming a different state of matter. With this respect, the Turin Shroud can be considered as a two-thousand-old relic witnessing to the humanity, just in the age of science, the reasonableness of the faith in the resurrection.
Potencialidad-posibilidad: metafísica y ciencia
Authors: Lázaro Pulido Manuel , Anchústegui Igartua Esteban
Published: October 2024

En el presente trabajo abordamos la cuestión metafísica de la potencialidad física y su relación con la potencialidad metafísica como una cuestión que ayuda a comprender la tarea de la metafísica de la ciencia. Para ello nos planteamos tres cuestiones. Una relativa a la relación entre necesidad y contingencia que tiene varias ramificaciones lógicas y naturales, que filosóficamente se vierte en la visión de un mundo fenoménico o real y concomitantemente a la intersección entre la aproximación racional y la empírica. Una segunda abordará la solución dada a esta intersección necesidad-contingencia a través del cálculo de probabilidades y su evolución hacia la probabilidad o potencialidad cuántica. La tercera cuestión tendrá como punto clave las raíces metafísicas medievales que plantea la física cuántica, especialmente la metafísica modal de Juan Duns Escoto.
“He Worked with Human Hands”. Work as Human Action and Christ’s Action
Authors: Izquierdo César
Published: October 2024

The complexity of work in our time presents new challenges for a theology that understands this fundamental dimension of existence and gives it an integrating, truly human meaning and a path to holiness. In order to embrace all modern forms of work, a definition of work is proposed as an action that involves the whole person and leads to fulfilment through work. Not only is work not a punishment, but the punishment would be not to be able to work. In work there is a convergence between nature and spirit. In order for the relationship between them to be harmoniously realised, a mediation is necessary that can only be exercised by man in which both meet. This avoids the risk of materialism and spiritualism in the understanding of work. But this mediation is limited to "this" concrete work. In order for there to be a mediation that includes all work, a Mediator is necessary, and that Mediator is Christ. The work that Jesus of Nazareth carried out was an exercise of his pro-existence and was therefore redemptive and salvific. It is in union with Christ that human work finds its ultimate meaning and transcendent efficacy.
Non-surgical management of methicillin-sensitive Staphylococcus aureus bacteremia-related mediastinitis
Authors: Vignati Carlo , Pietragalla Alessandra , Dedivitiis Gianfranco , Mancini Maria Elisabetta , Agostoni Piergiuseppe
Published: October 2024

Background: Acute mediastinitis is rarely caused by haematogenous spread of a remote infection. In this respect, since the only medical therapy is usually unsuccessful, treating acute mediastinitis with no source of infection detected is very challenging and management not standardized. In this case report, we describe non-surgical management experience of acute mediastinitis caused by methicillin-sensitive Staphylococcus aureus. Case presentation: In a 79-year-old man judged not eligible for cardiac surgery, we attempted the infection source control through vacuum-assisted closure therapy, together with antimicrobial therapy. We observed gradual clinical, laboratory and radiologic improvements: reduced swelling and normalization of the white blood cell count and C-reactive protein level were associated with reduction in size of a periaortic abscess. Conclusion: We managed a clinical condition with high mortality risk with chronic antimicrobial therapy alone, a strategy that is rarely considered. With this medical strategy we achieved an optimal response to a clinical picture that does not allow any other approach.
How to keep individuals with dementia interested in eating and resolve causes behind loss of appetite
Authors: Ashurst Adrian M
Published: October 2024

Adrian Ashurst discusses the importance of suppporting residents’ dietary needs and what could be the reasons behind a loss of appetite.
Taking the Next Step
Authors: Harvey Bill
Published: October 2024

Bill Harvey finds out about a new intense pulsed light system from Spectrum and how one early adopter, Dr Valarie Jerome, has introduced its use into her practice with great success
Nurturing growth
Authors: Mantle Sarah
Published: October 2024

Sarah Mantle explores how to get the most out of the practice team
CPD: Strategies to increase success with new soft CL wearers
Authors: Samuels Adam , Morgan Philip , Sulley Anna
Published: October 2024

Adam Samuels, Professor Philip Morgan and Anna Sulley summarise a recent literature review on ways to increase success with new contact lens wearers in practice. (C105963, suitable for logging as one distance learning CPD point for optometrists, contact lens opticians and dispensing opticians)
CLEAR interactive - 7
Authors: Harvey Bill
Published: October 2024

Bill Harvey summarises your responses to the most recent BCLA CLEAR interactive CPD exercise (C105479)
Inspiring Best Practice
Authors: Retallic Neil
Published: October 2024

Neil Retallic offers an overview of this year's Specsavers Mini Professional Advancement Conferences (MiniPACs)
Expertise... We ‘DO’ Need More
Authors: Morris Paul
Published: October 2024

Paul Morris champions the need to more better skills development, especially with dispensing opticians, in the industry
Proactive prevention
Authors: Hobson Michelle
Published: October 2024

Michelle Hobson explains how to actively prevent sexual harassment in the workplace
Profession disappointed after bill dropped
Authors: McCarthy-McClean Andrew
Published: October 2024

Andrew McCarthy-McClean explores what the future holds for a national eye health strategy
CPD: Improving practice communication: part 2
Authors: Anderson Fiona
Published: October 2024

Fiona Anderson discusses the differing referral pathways within the UK effective triage and recognising red flags that require immediate referral
Protecting Electrical Workers in Conducting Locations with Restricted Movements
Authors: Mitolo Massimo
Published: October 2024

Conducting Locations with Restricted Movements (CLRs) pose unique electrical hazards due to the extensive presence of grounded conductive materials with which a person is likely to come into contact and the restricted freedom of movement of workers within these spaces. Extended physical contact is not solely a result of spatial constraints. It could also be associated with the specific tasks that workers need to execute. An example of this is work conducted on a transmission tower. This paper investigates the electrical safety measures necessary to protect operators in such environments. By examining the role of body resistance and the impact of different current pathways, this author highlights the inadequacy of the conventional disconnection of supply fault protection measure in CLRs. The paper discusses protective strategies, including supplementary equipotential bonding, use of double or reinforced insulation, electrical separation, and extra-low voltage systems. These measures are critical in mitigating the risk of electric shock and ensuring safety of workers in CLRs.
Study on Mechanical Properties and Fatigue of Cold-rolled Steel Plate for Distribution Transformer
Authors: Hailong Jia , Zhihui Wang , Shengjie Wang , Wenqiang Chen , Gaofei Liu , Jingzhi Liu
Published: October 2024

The oil tank steel plate of the distribution transformer is covered with welds, and the fatigue failure of the oil tank often occurs in the internal defects of fillet welds. Given the above problems, this paper puts forward the bearing capacity calculation formula of cold-rolled steel plate and carries on the force analysis of steel plate and the fatigue analysis of weld through finite elements. Based on the theory of plastic limit design, the ultimate flexural bearing capacity of the control section of steel plate members is proposed. The calculation formula of equivalent structural stress is given based on the calculation method of structural stress and linear elastic fracture mechanics, and the calculation method of fatigue life and fatigue cumulative damage is given. Then, the elastic-plastic equation is solved according to three criteria: Mises yield criterion, plastic flow criterion, and strengthening criterion. Based on the above numerical simulation analysis, the mechanical model of steel plate weld is constructed, the mesh is divided, the boundary conditions are restricted and the same load is applied. ABAQUS analysis results show that the stress distribution curve of the connector has a maximum value at X = 80 mm and X = 210 mm, that is, the top surface of the connector steel plate has an obvious stress concentration at 80 mm and 210 mm. When the length of the weld is not more than 60 times the size of the welding foot, the full section of the core plate will yield, and the maximum stress value of the weld element will not exceed the tensile strength value of the welding material. The error of the results calculated by the formula in this paper is mostly within 10%, and the rest is basically within 20%. Therefore, the bearing capacity formula of the steel plate in this paper has ideal calculation accuracy and can provide effective guidance for the design of distribution transformer oil tanks.
Mechanical Analysis and Optimization of Concrete Structures Based on Advanced Finite Element Method
Authors: Yang Xiao
Published: October 2024

This article explores the mechanical analysis and optimization problems of concrete structures based on the Advanced Finite Element Method. By integrating advanced numerical techniques with practical engineering cases, this study aims to improve the safety and economy of concrete structure design. Firstly, the paper outlines the limitations of traditional finite element methods in concrete structure analysis, such as insufficient computational accuracy and low computational efficiency. Subsequently, by introducing AFEM, we significantly improved the accuracy and efficiency of the analysis. For example, when simulating a complex bridge structure, AFEM not only reduces the calculation time by about 25%, but also improves the accuracy of stress distribution prediction by more than 10%. In the optimization stage, we utilized the analysis results of AFEM and optimized the material consumption, cross-sectional dimensions, and reinforcement parameters of concrete structures through multi-objective optimization algorithms. A comprehensive data analysis underscores that the optimized concrete structure triumphantly meets all safety performance criteria while achieving a remarkable 12% reduction in material usage. This substantial material savings translates into a substantial 8% decrease in overall construction costs, significantly bolstering the project’s economic feasibility. Moreover, these cost savings not only amplify the project’s profitability but also play a pivotal role in enhancing the structure’s longevity and durability, thereby contributing to its sustainable performance over its entire service life. Furthermore, we delved into the capability of AFEM in simulating intricate phenomena such as the nonlinear behavior of concrete materials, crack propagation patterns, and the intricate interactions between steel reinforcements and concrete. These complex mechanical behaviors are crucial for the safety and stability of structures, and AFEM provides more comprehensive and accurate references for structural design by accurately simulating these behaviors. This article conducts in-depth research on the mechanical analysis and optimization of concrete structures based on AFEM, and demonstrates the significant advantages of AFEM in improving structural safety and economy through specific data. These research results not only provide new theoretical support and practical tools for concrete structure design, but also provide valuable references for future research and application in related fields.
Extraordinary variance in meta-analysis of venom toxicity of 160 most lethal ophidians and guidelines for estimating human lethal dose range
Authors: P. Hanley Brian , Gross Gustavo
Published: October 2024

Background: This is the first meta-analysis to characterize intra-ophidian-species variation in whole venom. Being the largest possible meta-analysis at this time, it encompasses all known records of animal lethality studies over the past 100 years. These results were not artifacts of resistant test-animal species and showed orders of magnitude beyond the 1.6 logs (40-fold change) range of lethal dose documented in the literature between amphibians, lizards, and mice. Methods: A total of 1003 lethal dose study results for 160 of the most lethal venomous ophidian species in the world were analyzed. Results: LDLo was not different from LD50 across studies, indicating the true range of toxicity is probably larger. The belief that, for the route of inoculation, IC < IV < IP < IM < SC was well supported (R2 = 0.90). However, 5% of ICs were the highest dose, and 7% of SC inoculations were the lowest dose. Within the mouse test species, for one route of inoculation, the widest LD range was 2.96 logs (917-fold change, N = 20). Within mouse species, for multiple routes of inoculation, the widest LD range was 3.6 logs (4,150-fold change, N = 20). The strongest correlation for the range of lethal dose results was the number of studies (R2 = 0.56), followed by the number of test-animal species (R2 = 0.55) and then the number of routes of inoculation (R2 = 0.43). Conclusion: Scientists working with humans should use combined LDLo and LD50 meta-datasets for all data and calculate mean, median, minimum, range, and standard deviation as shown in the supplement spreadsheet, and the equations we provide. Standard deviation multiples may provide the desired safety for experimenters. For estimating the LD50 range and minimum lethal dose for species with little data, we recommend curating a meta-dataset of related snakes, and computational research to strengthen this estimation.
End tuberculosis strategy also requires initiation and integration of a national silicosis control program with the ongoing tuberculosis elimination activities: A review of the silicotuberculosis situation in India
Authors: Sarkar Bidisa , Sarkar Kamalesh
Published: October 2024

Background: Earlier studies conducted by Indian researchers have demonstrated that the elimination of tuberculosis (TB) requires proactive control of silicosis, given India’s significant burden of silicosis and its common comorbidity, pulmonary TB, also known as silicotuberculosis. The TB Control Indian Health Authority saw human immunodeficiency virus infection, diabetes, and malnutrition, among others, as important risk factors for case findings, but overlooked the significance of silicosis. Silicotuberculosis control is often confronted with challenges of detecting microorganisms, uncertain treatment outcomes, a higher likelihood of mono-drug and multi-drug resistance, and increased mortality due to treatment failure. In addition, silicosis has a long latent period, typically 15 years or more, from the onset of silica dust exposure to the appearance of opacities on radiological examination, which is the conventional method of diagnosis of the condition. Objective and recommendation: Facing the aforementioned situation, scientists of the Indian Council of Medical Research-National Institute of Occupational Health have identified a useful biomarker, Club cell secretory protein 16 (CC-16) (a lung protein), that might serve as a surrogate marker for early detection of silicosis among silica dust-exposed workers. An added benefit of CC-16 is its ability to detect sub-radiological silicosis, which is recognized as a risk factor for TB and multi-drug-resistant TB. At present, two researchers have developed point-of-care devices for detecting silica-dust-induced lung damage using serum CC-16, to support its further application. Conclusion: The present review highlights possible mechanisms for the early detection of silicosis and silicotuberculosis by assessing several relevant research publications, and the findings suggest that a national silicosis control program, to be integrated with existing TB elimination activities for sustainable and improved outcomes, should be initiated.
Resultados de aprendizaje en ingeniería para niños con altas capacidades intelectuales
Authors: Lozano Tafur Cristian , Lozano Espinosa Nelson Eduardo , Aldana Rodríguez Didier
Published: October 2024

Objetivo: Desarrollar la adaptación curricular de los resultados de aprendizaje pertenecientes a espacios académicos de ingeniería, para un niño que muestra altas capacidades intelectuales.
Metodología: El estudio de caso corresponde a una investigación de categoría mixta donde se desarrolla la adaptación curricular en el entorno de ingeniería a un niño con índices de altas capacidades intelectuales. Se desarrolla por medio de diferentes etapas: diagnóstico, adaptación curricular y evaluación, teniendo como marco de referencia las inteligencias múltiples a través de una ruta de aprendizaje basada en proyectos.
Resultados: Los resultados obtenidos muestran en el diagnóstico que el sujeto de estudio presenta un alto grado de interés en ingeniería aplicada, así como conocimientos y un grado de interés en fundamentación. La ruta de aprendizaje permitió al estudiante a través de la evaluación presentar un cumplimiento cercano al 95 % de los objetivos de aprendizaje, por medio de aprendizaje basado en proyectos.
Conclusiones: La adaptación curricular pertenece a una estrategia del enriquecimiento curricular, la cual permite a las instituciones educativas adaptar sus objetivos en torno a las necesidades de los alumnos, especialmente de aquellos con altas capacidades intelectuales. Adicionalmente, dicha adaptación se aplica de manera transversal a la ingeniería con el propósito de fortalecer las rutas de aprendizaje y las evaluadoras.
A METHOD FOR THE STRATEGIC PLANNING OF AN INDUSTRIAL ENTERPRISE IN A HIGHLY TURBULENT ENVIRONMENT
Authors: Vaisman Elena , Zheleznova Tat'yana
Published: October 2024

The increasing speed of changes in the environment of industrial enterprises has led to the more frequent use of the term ‘turbulence’ and to the search for a method of strategic planning in this context. The hypothesis of the study is that this method should be based on two key criteria: firstly, a quantitative assessment of turbulence in the industrial environment of the enterprise and, secondly, the degree of resistance. The study develops a matrix for selecting the most effective method of strategic planning, depending on the selected criteria. The methodological basis of the study was the theory of organization and the theory of strategic management. The study used structural and logical analysis of information, and methods of statistical evaluation, matrix construction, and graphics. A Stacey matrix is developed, in which four possible zones of industrial enterprises are conditionally allocated: the zone of ‘conditional comfort’, the zone of ‘additional opportunities’, the zone of ‘threats’, the zone of ‘main risk’. The higher the level of turbulence in the industry and the lower the level of resistance of the in-dustrial enterprise, the more effective the application of integrated methods of strategic planning. An al-gorithm for assessing the effectiveness of accelerating the response to environmental changes is pro-posed. The key conclusion of the research is the confirmation of the hypothesis. The results can be used in the strategic management systems of industrial enterprises.
Balancing Innovation and Profitability: Technological Diversification in Iran’s Insurance Industry
Authors: Shojaei Seyed Amirhossein , Almansour Bashar Yaser
Published: October 2024

This study explores how technological diversification affects financial performance in Iran’s insurance industry. Using semi-structured interviews with six experts, including CEOs and faculty members, key indicators of technological diversification were identified, such as new underwriting software and digital advertising platforms. A 33-item questionnaire was developed based on these insights and distributed to top managers of Iranian insurance companies, with secondary financial data sourced from the Central Insurance of Iran. The study employes regression analysis and Partial Least Squares Structural Equation Modeling (PLS-SEM) to assess the impact of technological diversification on financial performance, controlling for firm size, debt ratio, and company age. Findings indicate a significant negative relationship between technological diversification and both Return on Equity (ROE) and Return on Assets (ROA), suggesting that the costs of adopting new technologies may outweigh their short-term financial benefits. Additionally, high debt ratios were found to adversely affect ROA, highlighting the financial risks of excessive borrowing.
Study on recrystallization process of nitroguanidine by directly adding cold water to control temperature
Authors: Zhang Jianjuan
Published: October 2024

Nitroguanidine (NGu), as a kind of high-energy material, is widely used as explosive propellant and energy component of explosives and smokeless powder. However, NGu crystals prepared by crystallization process are hollow and long needles, and their bulk density and bombing performance are greatly limited due to the high energy density at the tip, large porosity, and poor fluidity. Surprisingly, the particle size and morphology of NGu can effectively be improved by the recrystallization process. In this article, the recrystallization process by directly adding cold water to control temperature is first proposed, aiming to improve the morphological characteristics and reduce the particle size of NGu. Through single factor experimental research, the influences of various operating parameters on the morphology and particle size of NGu during recrystallization process were studied in detail. The results showed that the smallest average particle size of NGu was 19.8 μm when the crude NGu concentration, cold water temperature, volume ratio of boiling to cold water, stirring speed, and polyvinyl alcohol concentration were 5 g/100 mL, 0°C, 1:1, 800 rpm, and 0.35 g/100 mL, respectively. Correspondingly, the morphology of NGu was short rod, which was helpful to improve the bulk density. This novel recrystallization process has great potential to improve the NGu morphological characteristics, providing a new idea for the preparation of military NGu with small particle size and high bulk density.
Rising datives: tomar ‘take’ expressions with nouns of ‘emotion’ and constructional network reconfiguration in Spanish
Authors: Alba-Salas Josep
Published: October 2024

This diachronic, corpus-based study examines Spanish constructions formed with the verb tomar ‘take’ and nouns of ‘emotion’, including endogenous nouns with a target participant (e.g. cariño ‘affection’), exogenous nouns with a source or cause participant (e.g. tristeza ‘sadness’), and hybrid nouns allowing both options (e.g. miedo ‘fear’). Such constructions involve three different inchoative (‘begin to feel’) subschemas. The first one, the Prepositional-Stimulus subschema (e.g. tomar tristeza de algo ‘grow sad over something’), included exogenous and hybrid nouns and predominated in the Middle Ages, but disappeared by the 1800s. The other two subschemas, formed with endogenous and hybrid nouns, have survived until today. They include the Prepositional-Goal subschema (e.g. tomar cariño por alguien ‘grow fond of someone’), the most frequent of the two in the Middle Ages, and the Dative-Goal subschema (e.g. tomarle cariño a alguien ‘grow fond of someone’, lit. ‘take fondness to someone’), which presumably arose through analogy in the 1400s and subsequently marginalized its prepositional counterpart, becoming the default realization in present-day Spanish. Using the framework of Diachronic Construction Grammar, these changes are analyzed as involving the reconfiguration of a broader network of inchoative light verb constructions with nouns of emotion in Spanish.
Progress in cytokine research for ARDS: A comprehensive review
Authors: Zhou Kaihuan , Lu Junyu
Published: October 2024

Introduction

Acute respiratory distress syndrome (ARDS) is a critical form of acute respiratory failure characterized by diffuse alveolar damage, refractory hypoxemia, and non-cardiogenic pulmonary edema, resulting in high mortality. Dysregulated inflammation, driven by cytokines, is central to ARDS pathogenesis, progression, and prognosis.

Objective

This review synthesizes current knowledge on the role of cytokines in ARDS and evaluates their potential as therapeutic targets, offering new insights for clinical management.

Methods

A comprehensive analysis of recent studies was conducted to explore the roles of pro-inflammatory cytokines (e.g., IL-1β, IL-6, IL-8) and anti-inflammatory cytokines (e.g., IL-10, IL-22) in ARDS pathogenesis and to assess current and emerging therapies targeting these cytokines.

Results

Pro-inflammatory cytokines are crucial in initiating inflammatory responses and lung injury in early ARDS, while anti-inflammatory cytokines help regulate and resolve inflammation. Targeted therapies, such as IL-1 and IL-6 inhibitors, show potential in managing ARDS, particularly in COVID-19, but their clinical efficacy is still debated. Combination therapy strategies may enhance outcomes, but further large-scale, multicenter randomized controlled trials are required to establish their safety and efficacy.

Conclusion

Understanding cytokine regulation in ARDS could lead to innovative therapeutic approaches. Future research should focus on cytokine roles across ARDS subtypes and stages and develop biomarker-driven, individualized treatments.
Rapport de cas d’un nodule scléral focal chez un patient atteint d’un cancer de la prostate
Authors: Call Jaclyn , Cafiero-Chin Malinda , Chocky Michael
Published: October 2024

Il est essentiel de distinguer les lésions rétiniennes bénignes des lésions métastatiques pour une bonne prise en charge des patients. Avec les progrès de la tomographie par cohérence optique, l’imagerie peut désormais être utilisée pour déterminer des emplacements anatomiques précis, ce qui permet de nouvelles terminologies. Ce rapport de cas traite des résultats rétiniens chez un patient traité pour un cancer de la prostate et souligne l’importance de l’utilisation de la technologie pour différencier les nodules scléraux focaux des lésions choroïdiennes telles que les métastases choroïdiennes.
Comprehensive Teleoptometry Exams in Canada: A Proposed Clinical Framework
Authors: Blais Nicolas , Warren Adrianna , Woo Stan , Hanssens Jean-Marie
Published: October 2024

Purpose: Many high-income countries like Canada are faced with unmet needs regarding the availability of access to eye care, especially in rural, remote, or northern areas. Teleoptometry has the potential to improve access to primary eye care and help prevent, detect, diagnose and treat uncorrected refractive error and sight-threatening eye diseases. Given the rapid adoption of technology for virtual care during the COVID pandemic, the existing teleoptometry guidelines in Canada are limited in scope and may lead to uncertainty for optometrists practicing remote care. The purpose of this paper is to build a scaffold that highlights the similarities and differences between an in-person comprehensive eye examination and one that is delivered through comprehensive teleoptometry in Canada. This proposed clinical framework draws from both the existing published literature and the clinical experience of the authors. This paper discusses issues for teleoptometry including patient consent, efficiency, delegation, training and the patient pathway including referral protocols when indicated.
 
Results: Comprehensive teleoptometry eye exams are very similar to in-person eye exams, but they depend more on the assistance of an in-person technician/optometric assistant. The exams include delegated tests performed by an optometric assistant and tests controlled remotely by the optometrist like refraction. However, other tests that require clinical judgment to execute or interpret should be performed by the optometric assistant under the direct supervision of the remote optometrist using live video. The remote optometristbe able to repeat any test during videoconferencing.
 
Conclusion: Teleoptometry is a tool optometrists can use to reach patients that struggle to access an in-person eye exam. This evidence-informed, draft framework provides a point of reference for discussion by the Federation of Optometric Regulatory Authorities of Canada and the provincial regulatory authorities to protect the public and increase access through the delivery of remote primary eye care in Canada.
Herpes Simplex Epithelial Keratitis and Contact lens: A Case Report
Authors: Li Ziqing
Published: October 2024

Herpes simplex virus keratitis is an ocular infection arising from the reactivation of HSV; if not promptly addressed, it can lead to diminished visual acuity and potential blindness in the affected eye. The sight-threatening aspects of this infection are primarily associated with the development of scarring and opacity. A 22-year-old woman, an otherwise healthy contact lens wearer, sought medical attention with complaints of painful, red, and photophobic eyes. Upon examination, a dendritic ulcer was observed on the right eye, accompanied by toxic keratopathy in both eyes. The treatment regimen that was implemented consisted of valacyclovir and ocular lubrication. The disruption of the host's natural immunological barriers, exacerbated by suboptimal contact lens handling, paved the way for subsequent dendritic ulceration. This occurrence was instigated by the reactivation of the herpes simplex virus, underscoring the critical importance of timely intervention.
E-Cigarettes in Young People: Who is the Man Behind the Scenes?
Authors: Vaughn Donald Bernard
Published: October 2024

The prevalence of e-cigarette use among young people has become a growing concern, prompting the question of who is responsible for the promotion and marketing of these products to the vulnerable demographic: children and adolescents. The man behind the scenes in this scenario often is complicated. As we continue to navigate through the complexities surrounding e-cigarettes and youth consumption, it is essential that policymakers, public health officials, and parents work together to address this issue and prevent further harm to our future generations.
La creación de una divisa: el príncipe Felipe, Gaspar de Vega y el Monasterio de San Felipe el Real de Madrid
Authors: Herranz Juan
Published: October 2024

El estudio que ahora nos ocupa es el resultado del hallazgo del dibujo de una divisa que, junto con otras noticias que hemos podido reunir, hacen referencia a la creación y desarrollo del convento de San Felipe el Real de Madrid. En la documentación manejada aparecen vinculados con el proyecto constructivo, por una parte la figura del Príncipe Felipe como patrocinador y el prior Fray Alonso de Madrid como cliente y usuario y por otra parte Gaspar de Vega como responsable de su edificación. Este proceso nos ha ilustrado, en una fecha temprana, acerca de la preocupación del futuro Rey por la arquitectura, que fue una constante a lo largo de su existencia: también nos ha servido para aclarar hasta qué punto y en qué momento comenzaron las relaciones entre este maestro real y Felipe II, y por último nos ha permitido identificar y datar el dibujo de la anónima divisa.
La Academia de Roma y la tardía modernización de la pintura en España (1900-1915)
Authors: Reyero Carlos
Published: October 2024

La Academia Española de Bellas Artes de Roma tuvo un papel importante en el desarrollo de la pintura moderna en España a comienzos del siglo XX, a pesar de su tradicional reglamento. Los pensionados (en su mayoría -pintores de historia, aunque también hubo paisajistas), estaban obligados a realizar un dibujo de estatua clásica, una pintura original con estudios de desnudo de tamaño natural, la copia de un cuadro antiguo y una gran pintura de asunto. Sin embargo, estuvieron conectados con tendencias post-impresionistas: unos estuvieron interesados en temas simbolistas y otros en la percepción visual de la realidad. El presente trabajo, basado en una investigación documental en Roma, muestra su actividad artística durante el periodo de pensión entre 1900 y 1915.
El primer viaje a Italia del Marqués de Zenete
Authors: Falomir Faus Miguel , Marías Franco Fernando
Published: October 2024

En este breve artículo, se aportan pruebas documentales de un nuevo y primer viaje a Italia, previo a su estancia romana de 1504-6, del I Marqués del Zenete, el importante comitente del Castillo de La Calahorra, una de las primeras obras arquitectónicas del Renacimiento español; además de trazarse su itinerario por la península itálica, se abordan varios problemas relativos a su biografía y su carácter.
Un error de Llaguno que se arrastra hasta nuestros días: la supuesta visita a la Catedral de Segovia de los maestros, Álava, Covarrubias, Egas y Bigarny en 1529
Authors: Castro Santamaría Ana
Published: October 2024

Por un error de Llaguno, repetido por diversos estudiosos hasta nuestros días, se creía que en 1529 la catedral de Segovia recibió la visita de varios maestros, que acudirían para hacer sus propuestas sobre cómo habría de continuarse la obra. Efectivamente, en el archivo de la catedral de Segovia se encuentran diversos informes de los maestros Juan de Alava, Alonso de Covarrubias, Enrique Egas y Felipe Bigarny. En este artículo, queremos demostrar que estos informes no se refieren a la catedral de Segovia, sino a la de Salamanca, y que se encuentran en Segovia porque fueron mandados copiar por el canónigo segoviano Juan Rodríguez. Los pareceres de Alava y Covarrubias -que son los que centran nuestra atención- defienden la prosecución de la obra de Salamanca con naves a igual altura, es decir, con planta salón. Estos documentos se deben inscribir en una polémica muy viva que tuvo lugar en tomo a las obras de la catedral salmantina y en la que estuvieron implicados también Rasines, Vasco de la Zarza, Egas y Riaño y que, de mano de estos dos últimos, acabó en triunfo de la tesis tradicional de naves escalonadas.
Gaspar de Vega y Rodrigo Gil de Hontañón, alternativas al proyecto conventual de San Benito El Real de Valladolid
Authors: Herranz Juan
Published: October 2024

En este breve trabajo se va a dar a conocer la participación del maestro real Gaspar de Vega en el proceso constructivo del convento de San Benito el Real de Valladolid. Este dato nos ha permitido concretar y esclarecer la autoría de unos planos depositados en el Archivo Histórico Nacional.
Entre las dos riberas: Imbricaciones histórico-artísticas en torno a los portugeses: Nunes y Fernandes
Authors: Ávila Padrón Ana Victoria
Published: October 2024

En torno a los pintores portugueses Pere Nunyes y Enrique Femandes se analizan las relaciones histórico-artísticas entre Portugal y España así como el ambiente profesional de Barcelona en la primera mitad del siglo XVI en que la repetición de esquemas y el grabado como modelo jugaron un papel capital.
Obra documentada de Antonio de Arfe para el VI Conde de Benavente: Estudio de tipos de platería civil en el siglo XVI
Authors: Santamaría Blanca
Published: October 2024

Anuario del Departamento de Historia y Teoría del Arte
El San Bartolomé del Greco: Problemas formales e iconográficos
Authors: Kerestetsis Konstantinos
Published: October 2024

Anuario del Departamento de Historia y Teoría del Arte
A Administração da arquitectura: o Provedor das Obras Reais em Portugal no século XVI e na 1ª metade do século XVII
Authors: Soromenho Miguel
Published: October 2024

Anuario del Departamento de Historia y Teoría del Arte
La entrada de la reina María Ana de Neoburgo en Madrid (1690): Una decoración efímera de Palomino y de Ruiz de la Iglesia
Authors: Zapata Fernández de la Hoz María Teresa
Published: October 2024

Para la entrada de María Ana de Neoburgo, el Ayuntamiento de Madrid proyectó la construcción de una serie de monumentos efímeros, entre los cuales incluyó una galería de arcos alrededor de La fuente de San Salvador; decoración que encomendó a dos artistas consagrados : Antonio Palomino y Francisco Ignacio Ruiz de la Iglesia, quienes se encargaron, no sólo de la parte arquitectónica, sino también de la parte iconográfica y simbólica, así como de la composición de las letras de los jeroglíficos, algo totalmente inusual. En este artículo se analizan diferentes aspectos de esta decoración, se estudian las fuentes iconográficas, así como otros asuntos relacionados con el proyecto del libro que sobre esta entrada pensaba publicar el Ayuntamiento.
La otra cara de la Ilustración: La formación artística y la cultura del grabador Manuel Salvador Carmona a través del inventario de sus bienes (1778)
Authors: Blanco Mozo Juan Luis
Published: October 2024

A través del inventario de bienes que Manuel Salvador Carmona (1734-1820) poseía en 1778 se ha estudiado la formación artística y la cultura de este grabador. Su estancia francesa marcó profundamente su carrera artística. En París aprendió de los grandes grabadores de la escuela francesa del siglo XVII y de los artistas que dominaron las Bellas Artes en la década de los años 50, con Cochin hijo a la cabeza. En lo ideológico recibió las influencias del librepensamiento francés. La posesión de libros prohibidos, su amistad con el grabador francés Choffard y su pertenencia a la Real Sociedad Bascongada de los Amigos del País lo sitúan en una posición incómoda dentro del fenómeno ilustrado, en lo que hemos denominado, la otra cara de la Ilustración, junto con otros artistas como Ventura Rodríguez, su sobrino Manuel Martín Rodríguez, Luis Paret o Benito Bails.
Mechanisms for ensuring economic stability and security on the basis of national rootedness of economic development
Authors:   State Institution “Institute for Economics and Forecasting, NAS of Ukraine”, Grytsenko Andrii
Published: October 2024

The article shows that the countries that made an economic breakthrough and entered the world of states with high per capita incomes in any variant of using the strategies of catch-up or anticipatory development, export orientation or import substitution relied on the creation of industries in their own country, that is, on nationally rooted development. The author reveals the content of nationally rooted development as a basis for economic stability and security. The relationship between the concepts of "sustainability" and "resilience" has been clarified. "Resilience" is interpreted as a specific form of stability of an economic object, associated with its flexibility and ability to recover from destructive impacts. In a broader context, the sustainability of economic development is considered as the ability to develop the production of a network of various goods (material and ideal, public and individual, institutional and social) to meet the needs of society, its communities and citizens on the basis of technical and technological development and its corresponding socio-economic organization, which is based on the comprehensive use of national resources and international cooperation to create added value in the national space-time and has the property of maintaining dynamic balance in conditions of uncertainties and destabilizing influences of the hybrid "peace-war" system. The author reveals the mechanisms for ensuring the national rooting of economic development as the basis of its stability and security. It is shown that the components of the structure of these mechanisms are goal setting with scientific justification of the relevant policy, strategic planning and development of planning and market mechanisms for solving strategic tasks with logistical, organizational and monetary support for achieving the goal of nationally rooted development. It is concluded that national projects should become the key organizational link of the mechanism of national rooting of economic development. The article shows that in conditions of uncertainty and extreme complexity of social processes, it is possible to solve the task of national rooting of economic development only by relying on a meritocratic approach to management.