bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated analysis of endoplasmic reticulum stress regulators’ expression identifies distinct subtypes of autism spectrum disorder
Authors: Li Yanjun , Gao Songyin , Meng Yuelan
Published: April 2023

Endoplasmic reticulum (ER) stress has been demonstrated to play important roles in a variety of human diseases. However, their relevance to autism spectrum disorder (ASD) remains largely unknown. Herein, we aimed to investigate the expression patterns and potential roles of the ER stress regulators in ASD. The ASD expression profiles GSE111176 and GSE77103 were compiled from the Gene Expression Omnibus (GEO) database. ER stress score determined by the single sample gene set enrichment analysis (ssGSEA) was significantly higher in ASD patients. Differential analysis revealed that there were 37 ER stress regulators dysregulated in ASD. Based on their expression profile, the random forest and artificial neuron network techniques were applied to build a classifier that can effectively distinguish ASD from control samples among independent datasets. Weighted gene co-expression network analysis (WGCNA) screened out the turquoise module with 774 genes was closely related to the ER stress score. Through the overlapping results of the turquoise module and differential expression ER stress genes, hub regulators were gathered. The TF/miRNA-hub gene interaction networks were created. Furthermore, the consensus clustering algorithm was performed to cluster the ASD patients, and there were two ASD subclusters. Each subcluster has unique expression profiles, biological functions, and immunological characteristics. In ASD subcluster 1, the FAS pathway was more enriched, while subcluster 2 had a higher level of plasma cell infiltration as well as the BCR signaling pathway and interleukin receptor reaction reactivity. Finally, the Connectivity map (CMap) database was used to find prospective compounds that target various ASD subclusters. A total of 136 compounds were significantly enriched. In addition to some specific drugs which can effectively reverse the differential gene expression of each subcluster, we found that the PKC inhibitor BRD-K09991945 that targets Glycogen synthase kinase 3β (GSK3B) might have a therapeutic effect on both ASD subtypes that worth of the experimental validation. Our finding proved that ER stress plays a crucial role in the diversity and complexity of ASD, which may inform both mechanistic and therapeutic assessments of the disorder.
Predictors of support for anti-weight discrimination policies among Canadian adults
Authors: Levy Matthew , Forouhar Vida , Edache Iyoma Y. , Alberga Angela S.
Published: April 2023

Introduction

Weight discrimination of individuals with overweight or obesity is associated with adverse mental and physical health. Weight discrimination is prevalent in many sectors such as within workplaces, where individuals with overweight and obesity are denied the same opportunities as individuals with lower weight status, regardless of performance or experience. The purpose of this study was to understand the Canadian public's support or opposition of anti-weight discrimination policies and predictors of support. It was hypothesized that Canadians will show support of anti-weight discrimination policies to some extent.

Methods

A secondary analysis was conducted on a previous cross-sectional sample of Canadian adults (N = 923, 50.76% women, 74.4% White) who responded to an online survey assessing weight bias and support of twelve anti-weight discrimination policies related to societal policies (e.g., implementing laws preventing weight discrimination) and employment-related policies (e.g., making it illegal to not hire someone due to their weight). Participants completed the Causes of Obesity Questionnaire (COB), the Anti-Fat Attitudes Questionnaire (AFA) and the Modified Weight Bias Internalization Scale (WBIS-M). Multiple logistic regressions were used to determine predictors of policy support.

Results

Support for policies ranged from 31.3% to 76.9%, with employment anti-discrimination policies obtaining greater support than societal policies. Identifying as White and a woman, being over the age of 45 and having a higher BMI were associated with an increased likelihood of supporting anti-weight discrimination policies. There were no differences between the level of support associated with attributing obesity to behavioral or non-behavioral causes. Explicit weight bias was associated with a reduced likelihood of supporting 8/12 policies. Weight Bias Internalization was associated with an increased likelihood of supporting all societal policies but none of the employment policies.

Conclusions

Support for anti-weight discrimination policies exists among Canadian adults, and explicit weight bias is associated with a lower likelihood of supporting these policies. These results highlight the need for education on the prevalence and perils of weight discrimination which may urge policy makers to consider weight bias as a form of discrimination that must be addressed. More research on potential implementation of anti-weight discrimination policies in Canada is warranted.
The work of Chinese chronic conditions: adaptation and validation of the Distribution of Co-Care Activities Scale
Authors: Zhou Mingyue , Liu Mingxin , Lu Qi , Hou Bailing , Yuan Yue , Pan Sien , Zhang Huijun
Published: April 2023

Purpose

The Distribution of Co-Care Activities Scale was adapted into Chinese for the purposes of this study, and then the psychometric characteristics of the Chinese version of the DoCCA scale were confirmed in chronic conditions.

Methods

A total of 434 patients with chronic diseases were recruited from three Chinese cities. A cross-cultural adaptation procedure was used to translate the Distribution of Co-Care Activities Scale into Chinese. Cronbach's alpha coefficient, split-half reliability, and test-retest reliability were used to verify the scale's reliability. Content validity indices, exploratory factor analysis, and confirmatory factor analysis were used to confirm the scale's validity.

Results

The Chinese DoCCA scale includes five domains: demands, unnecessary tasks, role clarity, needs support, and goal orientation. The S-CVI was 0.964. Exploratory factor analysis yielded a five-factor structure that explained 74.952% of the total variance. According to the confirmatory factor analysis results, the fit indices were within the range of the reference values. Convergent and discriminant validity both met the criteria. Also, the scale's Cronbach's alpha coefficient is 0.936, and the five dimensions' values range from 0.818 to 0.909. The split-half reliability was 0.848, and the test-retest reliability was 0.832.

Conclusions

The Chinese version of the Distribution of Co-Care Activities Scale had high levels of validity and reliability for chronic conditions. The scale can assess how patients with chronic diseases feel about their service of care and provide data to optimize their personalized chronic disease self-management strategies.
Is first pregnancy age associated with hypertension in the Chinese rural women population?
Authors: Du Zhen , Wu Xueyan , Liao Wei , Hu Ze , Yang Jing , Dong Xiaokang , Zhao Hongfei , Liu Xiaotian , Wang Chongjian , Zhao Bing
Published: April 2023

Introduction

The purpose of this study was to investigate the relationship between first pregnancy age and hypertension later in the life of women from Chinese rural areas.

Methods

In total, 13,493 women were enrolled in the Henan Rural Cohort study. Logistic regression and linear regression were used to evaluate the association between first pregnancy age and hypertension and blood pressure indicators [including systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP)]. The restricted cubic spline was used to examine the dose–response relationship between the first pregnancy age and hypertension or blood pressure indicators.

Results

After adjusting for potential confounders, each 1-year increase in first pregnancy age was associated with a 0.221 mmHg increase in SBP values, a 0.153 mmHg increase in DBP values, and a 0.176 mmHg decrease in MAP values (all P < 0.05). The β of SBP, DBP, and MAP showed a trend of first increasing and then decreasing with increasing first pregnancy age and there was no statistical significance after first pregnancy age beyond 33 years on SBP, DBP, and MAP, respectively. A 1-year increment in first pregnancy age was associated with a 2.9% [OR (95% CI): 1.029 (1.010, 1.048)] higher odds of prevalent hypertension. The odds of hypertension increased sharply and then eventually leveled off with an increment of first pregnancy age after adjusting for potential confounders.

Conclusion

First pregnancy age might increase the risk of hypertension later in life and might be an independent risk factor for hypertension in women.
Comparative analysis of prevention and control measures toward COVID-19 epidemic between Shanghai and Beijing
Authors: Meng Yueli , Wang Xi , Dong Pei , Yang Yujie , Wang Kun , Yan Xiaoling , Hu Guangyu , Mao Ayan , Qiu Wuqi
Published: April 2023

Purpose

By serving and providing a guide for other regional places, this study aims to advance and guide the epidemic prevention and control methods, and practices and strengthen people’s ability to respond to COVID-19 and other future potential public health risks.

Design/methodology/approach

A comparative analysis was conducted that the COVID-19 epidemic development trend and prevention and control effects both in Beijing and Shanghai. In fact, regarding the COVID-19 policy and strategic areas, the differences between governmental, social, and professional management were discussed and explored. To prevent and be ready for potential pandemics, experience and knowledge were used and summarized.

Findings

The strong attack of the Omicron variant in early 2022 has posed challenges to epidemic prevention and control practices in many Chinese cities. Shanghai, which had achieved relatively good performance in the fight against the epidemic, has exposed limitations in its epidemic prevention and control system in the face of Omicron. In fact, the city of Beijing has undertaken prompt and severe lockdown measures and achieved rather good results in epidemic prevention and control because of learning from Shanghai’s experience and lessons; adhering to the overall concept of “dynamic clearing,” implementing precise prevention and monitoring, enhancing community control, and making emergency plans and preparations. All these actions and measures are still essential in the shift from pandemic response to pandemic control.

Research limitations/implications

Different places have introduced different urgent policies to control the spread of the pandemic. Strategies to control COVID-19 have often been based on preliminary and limited data and have tended to be slow to evolve as new evidence emerges. Hence, the effects of these anti-epidemic policies need to be further tested.
Government health expenditures and health outcome nexus: a study on OECD countries
Authors: Anwar Asim , Hyder Shabir , Mohamed Nor Norashidah , Younis Mustafa
Published: April 2023

Introduction

The consistent increase in health expenditures is an integral part of health policy. The aim of this study was to investigate the impact of health expenditures on health outcomes in the OECD countries.

Method

We used the system generalized method of moments (GMM) for thirty eight OECD countries using panel data from 1996 to 2020.

Results and discussion

The findings show that health expenditures have a negative impact on infant mortality while positive on life expectancy. The results further verify that the income measured as GDP, number of doctors, and air pollution has a negative effect on infant mortality, while these variables have a positive effect on life expectancy in the studied countries. The outcome of the study suggests that health expenditures need to be properly utilized and improvements can be made in the health policies to increase the investment in health technology. The government should also focus on measures like economic and environmental to have long-lasting health outcomes.
Physical activity's impact on rural older adult health: The multiple mediating effects of education, income, and psychological capital
Authors: Sun Yujin
Published: April 2023

Introduction

This study aims to explore the influence mechanism of rural older adult health. By examining the mediating roles of education, income, and psychological capital in physical activity's impact on health, this study provides a reference for lifestyle interventions to improve the health level of rural older adults.

Methods

The analysis was conducted on a sample of 1778 rural older adults from CGSS2017, and data were analyzed using PROCESS V4.2 for multiple mediating effects.

Results

The findings indicate that physical activity impacts rural older adult health through multiple mediating pathways. The mediating role includes seven paths, comprising the independent effects of three mediating variables of income, education, and psychological capital, and the chain mediating effects generated together.

Discussion

Based on the influence mechanism of health on rural older adults, optimizing policy focus and developing a precise, interconnected, and sustainable health security system for older adults is necessary. These research results are of practical significance for advancing healthy aging in rural areas.
On the risks of secure attachment in infancy: Childhood irritability and adolescent depression predicted by secure attachment and high approach behaviours at 14-months towards a caregiver living with inter-parental violence
Authors: Hill Jonathan , Wright Nicky , Sharp Helen , Pickles Andrew , Steele Howard
Published: April 2023

Introduction

The secure infant turns to a caregiver for comfort when distressed or threatened. Does this level of openness create vulnerability where the caregiver is unsupportive or aggressive? In this study we examined prospectively whether secure attachment in infancy, and approach behaviours on reunion with a parent, were associated with childhood emotional dysregulation (irritability) and adolescent depression among children exposed to inter-parental violence.

Methods

We followed 219 families recruited from the general population during pregnancy (members of the Wirral Child Health and Development Study; WCHADS), with attachment assessments (Strange Situation Procedure; SSP) at 14 months, maternal interviews about inter-parental violence at 2.5, 5 and 7 years, and parent and teacher rated irritability at 9 years (CBCL). At age 13 years, 199 young people rated their levels of depression (SMFQ). In addition to the standard SSP classification, a latent variable reflecting approach behaviours during reunions was generated from the SSP dimensional scores and a factor score extracted. Analyses used path analysis using the gsem command in Stata.

Results

There were interactions between attachment security and inter-parental violence for age 9 irritability (p = .084) and age 13 depression (p = .039) which arose from greater levels of psychopathology among secure children exposed to inter-parental violence. Similarly, higher approach behaviours during SSP reunions among children exposed to inter-parental violence were associated with irritability (interaction term p = .004) and depression (interaction term p < .001). Among children who were not exposed to partner violence higher approach behaviours in the SSP were associated with lower irritability and depression.

Conclusion

Infant behaviours characteristic of attachment security in the Strange Situation Procedure may not equip children to deal with exposure to inter-parental violence and associated parental negativity.
Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights
Authors: Scarini João Figueira , de Lima-Souza Reydson Alcides , Lavareze Luccas , Ribeiro de Assis Maria Clara Falcão , Damas Ingrid Iara , Altemani Albina , Egal Erika Said Abu , dos Santos Jean Nunes , Bello Ibrahim Olajide , Mariano Fernanda Viviane
Published: April 2023

Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%–60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA). CXPA is a rare and aggressive malignant tumor, whose prevalence represents approximately 3%–6% of all salivary gland tumors. Although the pathogenesis of the PA-CXPA transition remains unclear, CXPA development requires the participation of cellular components and the tumor microenvironment for its progression. The extracellular matrix (ECM) comprises a heterogeneous and versatile network of macromolecules synthesized and secreted by embryonic cells. In the PA-CXPA sequence, ECM is formed by a variety of components including collagen, elastin, fibronectin, laminins, glycosaminoglycans, proteoglycans, and other glycoproteins, mainly secreted by epithelial cells, myoepithelial cells, cancer-associated fibroblasts, immune cells, and endothelial cells. Like in other tumors including breast cancer, ECM changes play an important role in the PA-CXPA sequence. This review summarizes what is currently known about the role of ECM during CXPA development.
How Warming Temperatures Affect Breeding Behavior in Graylag Geese
Authors: Frigerio Didone , Hemetsberger Francesca , Sumasgutner Petra , Kotrschal Kurt , Kleindorfer Sonia , Hemetsberger Josef
Published: April 2023

You might have heard that dedication and perseverance are important elements for success. This is particularly true for science, specifically the study of animal behavior. Collecting biological data for decades can help scientists to better understand slow environmental changes and their consequences. For instance, globally increasing temperatures may affect animal behavior and reproduction. We investigated if and how environmental changes, such as a long-term increase in temperature and milder winters, affect the reproduction of a population of graylag geese. To do that, we collected data for 29 years—by monitoring temperature, the number of eggs laid, and the number of young birds that survive to adulthood. We found a temperature increase over time (an effect of climate change), and that higher average temperatures had a positive effect on the reproductive success of the geese. This suggests that the flock of graylag geese we studied could profit from warming temperatures, perhaps because the time window favorable for laying eggs and raising young is prolonged when winters are milder.
The Faraday Effect Tracker of Coronal and Heliospheric Structures (FETCH) instrument
Authors: Jensen Elizabeth A. , Gopalswamy Nat , Wilson Lynn B. , Jian Lan K. , Fung Shing F. , Nieves-Chinchilla Teresa , Shelton Marta , Li Lihua , Deshpande Manohar , Purves Lloyd , Lazio Joseph , Manchester Ward B. , Wood Brian E. , Kooi Jason E. , Wexler David B. , Bale Stuart , Pevtsov Alexei , Jackson Bernard V. , Kenny Megan N.
Published: April 2023

There continue to be open questions regarding the solar wind and coronal mass ejections (CMEs). For example: how do magnetic fields within CMEs and corotating/stream interaction regions (CIRs/SIRs) evolve in the inner heliosphere? What is the radially distributed magnetic profile of shock-driving CMEs? What is the internal magnetic structure of CMEs that cause magnetic storms? It is clear that these questions involve the magnetic configurations of solar wind and transient interplanetary plasma structures, for which we have limited knowledge. In order to better understand the origin of the magnetic field variability in steady-state structures and transient events, it is necessary to probe the magnetic field in Earth-directed structures/disturbances. This is the goal of the Multiview Observatory for Solar Terrestrial Science (MOST) mission (Gopalswamy et al., 2022). For MOST to answer the aforementioned questions, we propose the instrument concept of the Faraday Effect Tracker of Coronal and Heliospheric structures (FETCH), a simultaneous quad-line-of-sight polarization radio remote-sensing instrument. With FETCH, spacecraft radio beams passing through the Sun–Earth line offer the possibility of obtaining information of plasma conditions via analysis of radio propagation effects such as Faraday rotation and wave dispersion, which provide information of the magnetic field and total electron content (TEC). This is the goal of the FETCH instrument, one of ten instruments proposed to be hosted on the MOST mission. The MOST mission will provide an unprecedented opportunity to achieve NASA’s heliophysics science goal to “explore and characterize the physical processes in the space environment from the Sun” (Gopalswamy et al., 2022).
Classification in Para skiing: do better performing skiers have better visual functions?
Authors: Stalin Amritha , Dalton Kristine
Published: April 2023

Introduction

Currently, Paralympic skiers with vision impairment are allocated to classes based only on their better eye static visual acuity and visual field diameter. These studies were conducted to investigate whether a broad range of visual functions were different among groups of skiers with different levels of skiing performance.

Methods

Static and dynamic visual acuities, contrast sensitivity, light and glare sensitivity, glare recovery, motion perception, and visual field were assessed binocularly in elite Para nordic (n = 26) and Para alpine skiers (n = 15) at 3 international Paralympic events. Skiing performances were calculated using modified skiing points systems based on skiers' raw race times. Clusters of skiers with similar performances were identified in each sport, and their vision and non-vision variables were compared.

Results

Skiers in the best performing Para nordic clusters (1 and 2) had better static visual acuities (p = 0.041) and larger visual fields (p = 0.004) compared to cluster 3. In Para alpine slalom (p = 0.019), giant slalom (p = 0.019), and Super-G (p = 0.039) the average static visual acuities among the better performing clusters were significantly better compared to the worst performing cluster. In slalom, the cluster with better performance also had a significantly larger visual field (p = 0.038). In downhill, the better performance cluster demonstrated better dynamic visual acuity (p = 0.029).

Discussion

Clusters with better performing skiers appear to have better visual function in both sports. The results of this study would suggest that Para nordic and Para alpine skiers with light perception or no light perception vision should be in one class and that the skiers with quantifiable static VA should be in a different class.
Characterization of transitional memory CD4+ and CD8+ T-cell mobilization during and after an acute bout of exercise
Authors: Hunt Rebekah M. , Elzayat Mahmoud T. , Markofski Melissa M. , Laughlin Mitzi , LaVoy Emily C.
Published: April 2023

T-cell subsets, including naïve (NA), central memory (CM), transitional memory (TM), effector memory (EM), and RA + effector memory (EMRA), differ in phenotype and function. T-cells are mobilized by exercise, with differences in the magnitude of mobilization between subsets. However, the response of TM T-cells to exercise has not yet been described. Further, T-cells expressing the late differentiation marker CD57 are known to be highly responsive to exercise, but the relative response of CD57 + and CD57- within T-cell subsets is unknown. We therefore aimed to characterize the exercise-induced mobilization of TM T-cells, as well as to compare the exercise response of CD57 + and CD57- cells within T-cell subsets.

Methods

Seventeen participants (7 female; aged 18–40 years) cycled 30 min at 80% of their estimated maximum heart rate. Venous blood obtained pre, post, and 1H post-exercise was analyzed by flow cytometry. CD45RA, CCR7, and CD28 expression within CD4 + and CD8+ T-cells identified NA, CM, TM, EM, and EMRA subsets. CD57 expression within EM, EMRA, and CD28+ T-cells was also quantified. The relative mobilization of each subset was compared by calculating fold change in cell concentration during (ingress, post/pre) and after exercise (egress,1H post/post). Cytomegalovirus (CMV) serostatus was determined by ELISA and was considered in models.

Results

TM CD8+ T-cell concentration was greater post-exercise than pre-exercise (138.59 ± 56.42 cells/µl vs. 98.51 ± 39.68 cells/µl, p < 0.05), and the proportion of CD8 + with a TM phenotype was elevated 1H post-exercise (1H: 32.44 ± 10.38% vs. Pre: 30.15 ± 8.77%, p < 0.05). The relative mobilization during and after exercise of TM T-cells did not differ from NA and CM but was less than EM and EMRA subsets. Similar results were observed within CD4+ T-cells. CD57 + subsets of CD28+ T-cells and of EM and EMRA CD8+ T-cells exhibited a greater relative mobilization than CD57- subsets (all p < 0.05).

Conclusion

These results indicate TM CD4 + and CD8+ T-cells are transiently mobilized into the blood with exercise, but not to as great of an extent as later differentiated EM and EMRA T-cells. Results also indicate CD57 identifies highly exercise responsive cells within CD8+ T-cell subsets.
Effects of daily static stretch training over 6 weeks on maximal strength, muscle thickness, contraction properties, and flexibility
Authors: Wohlann Tim , Warneke Konstantin , Hillebrecht Martin , Petersmann Astrid , Ferrauti Alexander , Schiemann Stephan
Published: April 2023

Purpose

Static stretch training (SST) with long stretching durations seems to be sufficient to increase flexibility, maximum strength (MSt) and muscle thickness (MTh). However, changes in contraction properties and effects on muscle damage remain unclear. Consequently, the objective of the study was to investigate the effects of a 6-week self-performed SST on MSt, MTh, contractile properties, flexibility, and acute response of creatine kinase (CK) 3 days after SST.

Methods

Forty-four participants were divided into a control (CG, n = 22) and an intervention group (IG, n = 22), who performed a daily SST for 5 min for the lower limb muscle group. While isometric MSt was measured in leg press, MTh was examined via sonography and flexibility by functional tests. Muscle stiffness and contraction time were measured by tensiomyography on the rectus femoris. Additionally, capillary blood samples were taken in the pretest and in the first 3 days after starting SST to measure CK.

Results

A significant increase was found for MSt (p < 0.001, η2 = 0.195) and flexibility in all functional tests (p < 0.001, η2 > 0.310). Scheffé post hoc test did not show significant differences between the rectus femoris muscle inter- and intragroup comparisons for MTh nor for muscle stiffness and contraction time (p > 0.05, η2 < 0.100). Moreover, CK was not significantly different between IG and CG with p > 0.05, η2 = 0.032.

Discussion

In conclusion, the increase in MSt cannot be exclusively explained by muscular hypertrophy or the increased CK-related repair mechanism after acute stretching. Rather, neuronal adaptations have to be considered. Furthermore, daily 5-min SST over 6 weeks does not seem sufficient to change muscle stiffness or contraction time. Increases in flexibility tests could be attributed to a stretch-induced change in the muscle–tendon complex.
Growing old together: What we know about the influence of diet and exercise on the aging host's gut microbiome
Authors: Brooks Chequita N. , Wight Madeline E. , Azeez Oluwatobi E. , Bleich Rachel M. , Zwetsloot Kevin A.
Published: April 2023

The immune system is critical in defending against infection from pathogenic microorganisms. Individuals with weakened immune systems, such as the elderly, are more susceptible to infections and developing autoimmune and inflammatory diseases. The gut microbiome contains a plethora of bacteria and other microorganisms, which collectively plays a significant role in immune function and homeostasis. Gut microbiota are considered to be highly influential on host health and immune function. Therefore, dysbiosis of the microbiota could be a major contributor to the elevated incidence of multiple age-related pathologies. While there seems to be a general consensus that the composition of gut microbiota changes with age, very little is known about how diet and exercise might influence the aging microbiome. Here, we examine the current state of the literature regarding alterations to the gut microbiome as hosts age, drawing particular attention to the knowledge gaps in addressing how diet and exercise influence the aging microbiome. Further, we will demonstrate the need for more controlled studies to investigate the roles that diet and exercise play driving the composition, diversity, and function of the microbiome in an aging population.
Reducing oil absorption of falafel balls by using edible coating films containing dried orange-albedo powder or dried apple peel during deep frying
Authors: Angor Malak
Published: April 2023

Introduction

The purpose of this study is to examine the effects of varying proportions of dried-orange-albedo and dried-apple-peel powders in edible coating films for falafel balls on their subsequent oil uptake and sensory properties when used during deep frying in oil.

Methods

Coating solutions of 3%, 5%, and 7% w/v of either orange albedo or apple-peel powder were prepared and heated to 90°C for 5 min, after which they were cooled. In the next step, the falafel-ball samples were air-dried after dipping them in the coating solutions. The falafel balls coated with different solutions were then deep-fried and their oil and moisture content with the calculation of oil uptake and moisture retention was analyzed, along with the evaluation of sensory attributes.

Results

According to the results, oil uptake during deep oil frying was reduced to varying extents in all coating treatments. For both orange albedo and apple-peel powder, the coating films containing 5% of either were found to be the most effective level in reducing the oil uptakes.

Discussions

The coating films prepared from orange albedo reduced oil uptake more than those containing the same amount of apple peel for all levels. All falafel ball samples prepared with the different coatings were found to have improved sensory features compared with the uncoated control.
Intradural extramedullary spinal cord meningioma with a rare extradural foraminal extension: A case report
Authors: Almatrafi Faisal , Alomair Majed , Alojan Abdulrazaq , Alkhaldi Mohammed , Alsafwani Noor , Aseeri Abdullah , Alshahrani Abdulelah , Alsalmi Sultan , Alqahtani Mohammad
Published: April 2023

Background

Meningiomas are mostly benign and slow-growing neoplasms of the central nervous system. Spinal meningiomas account for up to 45% of all intradural spinal tumors in adults and up to 25%–45% of all spinal tumors. Spinal extradural meningiomas are rare and may be easily confused with malignant neoplasms.

Case description

A 24-year-old woman was presented to our hospital with paraplegia and loss of sensation in the T7 dermatome and lower body. MRI findings showed T6-T7 right-sided intradural extramedullary and extradural lesion, measuring 1.4 cm × 1.5 cm × 3 cm, extending to the right foramen, compressing the spinal cord, and displacing it to the left. Hyperintense lesion on T2 and hypointense lesion on T1 were observed. The patient reported improvement after surgery and during follow-up. We recommend maximizing the decompression during surgery to achieve better clinical outcome. Extradural meningiomas represent 5% of all meningiomas; therefore, having an intradural on top of extradural meningioma with extraforaminal extensions makes this a unique and rare case.

Conclusion

Meningiomas can be easily missed in diagnosis depending on imaging and the pathognomonic pattern it represents, which can mimic other pathologies, such as schwannomas. Therefore, surgeons should always suspect their patient having a meningioma even if the pattern is not typical. Moreover, preoperative preparation, such as navigation and defect closure, must be taken in case it turns out be a meningioma instead of the presumed pathology.
Preliminary Aero-Elastic Optimization of a Twin-Aisle Long-Haul Aircraft with Increased Aspect Ratio
Authors: Toffol Francesco , Ricci Sergio
Published: April 2023

This paper presents a preliminary study on the improvement of the fuel efficiency of a civil transport aircraft, focusing on the aero-elastic optimization of an increased aspect ratio wingbox. The wing is stretched, increasing its aspect ratio, and a trade-off between the improved aerodynamic efficiency and the structural mass identifies an optimal aspect ratio for such aircraft. The aeroelastic optimization is performed with NeOPT, a structural optimizer for conceptual and preliminary design phases. The analysis considers different materials and structural solutions for the wingbox and tackles aeroelastic constraints, such as flutter and aileron efficiency, from the preliminary design phases. The fuel consumption of the sized aircraft is evaluated with a simplified approach that provides an indication of the fuel efficiency. The results show how a composite wing with increased aspect ratio can save up to 6.9% of fuel burnt with respect to the baseline aluminum wing. The results are extended at fleet level, achieving a 2-million-ton cut in CO2 emissions and a saving of USD 1.28 million on fuel-related costs.
Research on Path Tracking of Articulated Steering Tractor Based on Modified Model Predictive Control
Authors: Zhou Baocheng , Su Xin , Yu Hongjun , Guo Wentian , Zhang Qing
Published: April 2023

With the development of agricultural mechanization and information technology, automatic navigation tractors are becoming a more common piece of farm equipment. The accuracy of automatic navigation tractor path tracking has become critical for maximizing efficiency and crop yield. Aiming at improving path tracking control accuracy and the real-time performance of the traditional model predictive control (MPC) algorithm, the study proposed an adaptive time-domain parameter with MPC in the path tracking control of the articulated steering tractor. Firstly, the kinematics model of the articulated steering tractor was established, as well as the multi-body dynamics model by RecurDyn. Secondly, the genetic algorithm was combined with MPC. The genetic algorithm was used to calculate the optimal time domain parameters under real-time vehicle speed, vehicle posture and road conditions, and the adaptive MPC was realized. Then, path tracking simulations were conducted by combining RecurDyn and Simulink under different path types. Compared with the traditional MPC algorithm under the three paths of U-shaped, figure-eight-shaped and complex curves, the maximum lateral deviations of the modified MPC algorithm were reduced by 59.0%, 24.9% and 13.2%, respectively. At the same time, the average lateral deviation was reduced by 72%, 43.5% and 20.3%, respectively. Finally, the real path tracking tests of the articulated steering tractor were performed. The test results indicated that under the three path tracking conditions of straight line, front wheel steering and articulated steering, the maximum lateral deviation of the modified MPC algorithm was reduced by 67.8%, 44.7% and 45.1% compared with the traditional MPC. The simulation analysis and real tractor tests verified the proposed MPC algorithm, considering the adaptive time-domain parameter has a smaller deviation and can quickly eliminate the deviation and maintain tracking stability.
Design and Experimentation of a Longitudinal Axial Flow Sunflower Oil Threshing Device
Authors: Liu Wei , Ma Lina , Zong Wangyuan , Liu Jinyi , Li Mao , Lian Guodang
Published: April 2023

To address the problems of threshing loss and high impurity rate during sunflower oil harvesting, a vertical axial flow sunflower oil threshing device was designed. To reduce severe breakage of the sunflower plate and high entrainment loss rate when threshing by the traditional grating gravure sieve, a circular tube-type gravure screen was designed, and a contact model describing the grain rod, sunflower pan, and gravure screen was analyzed. The results show that reducing the diameter of the gravure screen round tubes can effectively reduce breakage of the sunflower pan. The range of the threshing gap, drum speed, and feed amount were determined by a single-factor test. Design-Expert software was used to design a response surface experiment: threshing gap, drum rotation speed, and feed amount were used as test factors, and the threshing loss rate of grains and the grain mass ratio of undersize grains were used as evaluation indicators. A regression model between test factors and evaluation indexes was established by variance analysis of the test results. A software-based numerical optimization function was used to reduce the loss rate of grains and increase the grain mass ratio of undersize grains. The optimal parameters of the threshing device were obtained by multi-objective optimization of all factors: the separation gap was 24.90 mm, drum speed was 244.14 r/min, feed amount was 2.95 kg/s, the threshing loss rate grains was 2.35%, and the grain mass ratio of undersized grains was 81.34%. This study can provide a reference for the design of a combined sunflower oil harvester threshing device.
An Inter-Ridge Navigation Path Extraction Method Based on Res2net50 Segmentation Model
Authors: Jin Xin , Lin Cheng , Ji Jiangtao , Li Wenhao , Zhang Bo , Suo Hongbin
Published: April 2023

The extraction of navigation lines plays a crucial role in the autonomous navigation of agricultural robots. This work offers a method of ridge navigation route extraction, based on deep learning, to address the issues of poor real-time performance and light interference in navigation path recognition in a field environment. This technique is based on the Res2net50 model and incorporates the Squeeze-and-Excitation Networks (SE) attention mechanism to focus on the key aspects of the image. The empty space pyramid pooling module is presented to further extract high-level semantic data and enhance the network’s capacity for fine-grained representation. A skip connection is used to combine the high-level semantic characteristics and low-level textural features that are extracted. The results of the ridge prediction are then obtained, followed by the realization of the final image segmentation, through sampling. Lastly, the navigation line is fitted once the navigation feature points have been retrieved using the resulting ridge segmentation mask. The outcomes of the experiment reveal that: the Mean Intersection over Union (MIOU) and F-measure values of the inter-ridge navigation path extraction approach suggested in this paper are increased by 0.157 and 0.061, respectively, compared with the Res2net50 network. Under various illumination situations, the average pixel error is 8.27 pixels and the average angle error is 1.395°. This technique is appropriate for ridge operations and can successfully increase network prediction model accuracy.
Simulation and Experiment of Compression Molding Behavior of Substrate Block Suitable for Mechanical Transplanting Based on Discrete Element Method (DEM)
Authors: Fu Jingjing , Cui Zhichao , Chen Yongsheng , Guan Chunsong , Chen Mingjiang , Ma Biao
Published: April 2023

The compression molding performance of a substrate block has a significant effect on the quality and stability of mechanical transplanting. The physical experiment and DEM simulation were combined to evaluate the compression molding behavior of substrate block in this study. A calibration procedure of DEM parameters of peat particles was proposed at first. Then, the above parameters were brought into the contact model of the compression system–particles, and the effect of the loading speed on the compression behavior of the peat substrate block was investigated. The compressive force–displacement curves of the simulated and measured tests were all contained in the initial linear stage and non-linear stiffing stage. The particle number of central sections was higher than side section, and the variable coefficient was greater at higher loading speed. The substrate blocks all expanded after demolding. The higher the loading speed, the greater the expansion in the height’s direction, and the easier it was for cracks to be generated near the bottom. This study will provide a reference for the design of substrate block forming machines.
Isolation, Characterization and Phylogenetic Analysis of Stagonospora tainanensis, the Pathogen Causing Sugarcane Leaf Blight in China
Authors: Huang Zhenxin , Shi Qian , Zeng Quan , Liang Haoming , Yu Quan , Meng Jiaorong , Chen Baoshan
Published: April 2023

Sugarcane leaf blight (SLB), a major fungal leaf disease of sugarcane (Saccharum spp.), has been attributed to Stagonospora tainanensis. In December 2020 and May 2021, signs of leaf blight were observed on sugarcane in the fields of Chongzuo City, in the Guangxi Province of China. Lesions on the leaves were characterized by yellow or dark red spots in the center. Fungal species were isolated, purified and subjected to pathogenicity evaluation on the sugarcane plants. An isolate that caused symptoms the same as those observed in the field was initially identified as S. tainanensis (Leptosphaeria taiwanensis, perfect state) based on its morphological characteristics both of asexual and sexual stages. Dark brown and nearly spherical pycnidia with conidia of long ellipsoidal, hyaline, one to four cells and 29.27 to 54.39 μm long and 9.03 to 16.12 μm wide were found on corn meal agar medium. Ascomata with asci of cylindrical to clavate, a short stipe and eight spores slightly constricted at the septum, with the size of the spore ranging from 36 to 44 μm long and 8.5 to 12 μm wide, were formed on the sugarcane-leaf-decoction saccharose agar medium. The identity of the species was further confirmed by rDNA ITS and TEF-1α sequencing. The optimal temperature for mycelial growth was 25 °C and the optimal pH was 6.0. The pathogen grew well in a medium with oats as the carbon source and yeast extract as the nitrogen source, but poorly in a medium with urea as the nitrogen source. This study is the first to identify the sugarcane leaf blight pathogen in Guangxi, and the first publication describing the biological characterization of S. tainanensis. The occurrence of sugarcane leaf blight should alert sugarcane breeders and plant pathologists to consider integrating control of this potentially important disease into the agenda of their breeding and disease control programs.
Impact of Operational Parameters on Droplet Distribution Using an Unmanned Aerial Vehicle in a Papaya Orchard
Authors: Ribeiro Luis Felipe Oliveira , Vitória Edney Leandro da , Soprani Júnior Gilson Geraldo , Chen Pengchao , Lan Yubin
Published: April 2023

Papaya production and export is increasingly expanding in the world market due to the nutritional importance of the fruit. Phytosanitary issues, labor shortages, and unevenness in land-based costal and motorized applications compromise crops, the environment, and humankind. The purpose of this study was to evaluate the efficiency of droplet distribution using an unmanned aerial vehicle, with different application rates (12.0, 15.0, and 18.0 L ha−1) and spray nozzles (XR110015 and MGA015) in the upper (UL), middle (ML), and lower (LL) layers, and on papaya fruit clusters (BF). Water-sensitive paper labels and artificial targets were used to assess the efficiency. Coverage, density, droplet distribution, and droplet diameter were influenced by the application rates in the following order: 18.0 > 15.0 > 12.0 L ha−1, showing concentrated droplet distribution in the respective layers: UL > ML > LL > BF. The 18.0 L ha−1 rate increased the variables examined, and the droplet coverage on the UL using the XR110015 nozzle was 6.56 times greater than that found on the LL and BF. The MGA015 nozzle presented better results in the LL and BF in all variables analyzed. The UAVs were efficient in applying to the papaya crop and further studies should be carried out in order to confirm the efficacy of plant protection products applied using this technology.
Efficient Micropropagation of Genetically Stable Panax ginseng Meyer by Somatic Embryogenesis
Authors: Lee Jung-Woo , Kim Jang-Uk , Bang Kyong-Hwan , Kim Dong-Hwi , Jo Ick-Hyun , Park Young-Doo
Published: April 2023

Panax ginseng Meyer is a valuable medicinal crop. However, the species’ propagation is limited by its long reproductive cycle and low seed yield. The present study focused on P. ginseng plant regeneration via somatic embryogenesis and evaluated the genetic stability of regenerated plantlets. We assessed the effects of carbon source type and concentration on somatic embryo induction, maturation, and germination. Somatic embryogenesis was optimal in Murashige and Skoog (MS) medium supplemented with 5% sucrose; however, maturation peaked in 1/2 MS containing low concentrations of sucrose ranging from 1 to 2%. Germination and plant regeneration were optimal in germination medium supplemented with 2% sucrose based on high germination rates, efficient plantlet production, and balanced growth characteristics. Molecular marker analysis suggested that the genetic fidelity of the regenerated plants was comparable with that of the control. High-performance liquid chromatography (HPLC) analysis showed that in vitro-grown roots (IGRs) accumulated more ginsenoside than those of the control, but the ginsenoside content of 2 year old IGRs was similar to that of the controls after acclimatization. Our study provides valuable insights into the optimization of genetically stable micropropagation and could promote the distribution of superior P. ginseng cultivars with high product yields and quality.
Effects of Genotype and Housing System on Rabbit Does’ Aggressive Behaviors and Injuries in Smallholding Conditions
Authors: Krunt Ondřej , Zita Lukáš , Kraus Adam , Moravcsíková Ágnes , Frühauf Kolářová Martina , Bartoš Luděk
Published: April 2023

The objective of the study was to investigate the effects of housing (deep litter + concrete floor vs. deep litter + ground soil with the possibility to dig burrows), and genotype (Mecklenburg or Hyplus) on aggressive behaviour, social contacts, does’ and kits’ injuries, and progeny mortality. Twelve groups of six rabbit does (n = 72) were assigned to four treatments (two housing systems and two genotypes). Aggressive behaviour of does, number of injuries on does and kits, and postnatal kit mortality were recorded. The effects of housing and genotype were tested using multivariate GLMM Models. We found that the housing treatment in interaction with the genotype had a significant effect on aggressive behaviours in group housed does (F3,12 = 14.34, p = 0.0003), where the lowest incidence of aggression was in Mecklenburg does housed on ground soil. Reduced aggression was reflected in a lower number of injuries in does (F3,68 = 10.51, p < 0.0001), number of injuries in kits, and kit mortality (F3,1 = 4.59, p < 0.0001, F3,54 = 43.94, p < 0.0001). The results indicate that the proper combination of genotype and housing should be carefully considered for breeding to reduce aggression and injury in group housed does.