bluuebunny/crossref_metadata_2025 huggingface dataset:
How Will “I” Versus “We” Perform? An Investigation of Future Outlooks and Self-Construals
Authors: Dean Kristy K. , Gardner Wendi L.
Published: April 2014

Previous theory and research suggests that people generate predictions to prepare for an uncertain future, often basing predictions on task-relevant information like prior performance. Four studies test the hypothesis that preparation via prediction occurs more readily when interdependent (vs. independent) self-construals are salient. This hypothesis was supported when examining chronic tendencies to generate negative predictions (Study 1) and spontaneous predictions in response to task-relevant information (Studies 2, 3, and 4), as well as when self-construals were measured (Studies 1, 2, and 4) and primed (Study 3). Moreover, performance prediction occurs in conjunction with increases in task persistence, but only for individuals with interdependent self-construals. Individuals with independent self-construals tend toward preparation via prediction only when preparation is urgent. Discussion centers on the applicability of within-cultural differences in self-construal on cross-cultural investigations, and implications for future research on predictive judgments.
The Relationship of Glucokinase Activator–induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies
Authors: Pettersen John C. , Litchfield John , Neef Natasha , Schmidt Stephen P. , Shirai Norimitsu , Walters Karen M. , Enerson Bradley E. , Chatman Linda A. , Pfefferkorn Jeffrey A.
Published: April 2014

Glucokinase activators (GKAs) are being developed for the treatment of type 2 diabetes. The toxicity of 4 GKAs (PF-04279405, PF-04651887, piragliatin, and PF-04937319) was assessed in mice, rats, dogs, and/or monkeys. GKAs were administered for 2 to 8 weeks. Standard endpoints, glucose, and insulin were assessed. All compounds produced varying degrees of hypoglycemia in all species. Brain neuronal necrosis and/or peripheral neuropathy were observed with most compounds. These findings are consistent with literature reports linking hypoglycemia with nervous system effects. Arteriopathy, mainly of cardiac vessels, was observed at a low frequency in monkey and/or dog. Arteriopathy occurred only at doses that produced severe and prolonged periods of repeated hypoglycemia. Since this lesion occurred in multiple studies with structurally distinct GKAs, these results suggested arteriopathy was related to GKA pharmacology. The morphological characteristics of the arteriopathy were consistent with that produced by experimental catecholamine administration. We hypothesize that the prolonged periods of hypoglycemia resulted in increased local and/or systemic concentrations of catecholamines via a counterregulatory and/or stress-related mechanism. Alternatively, prolonged hypoglycemia may have resulted in endothelial dysfunction leading to arteriopathy. This risk can be managed in human patients in clinical studies by careful glucose monitoring and intervention to avoid prolonged episodes of hypoglycemia.
A retrospective review of clopidogrel as primary therapy for migraineurs with right to left shunt lesions
Authors: Spencer Barbara T , Qureshi Yasir , Sommer Robert J
Published: April 2014

Background:

The association of patient foramen ovale (PFO) and migraine headache (migraine) with aura (MA) is well established. Current research suggests a mechanistic link between platelet activation, paradoxical embolization and migraine in some patients.

Methods:

Clopidogrel, a platelet inhibitor, was added to existing migraine therapy, as a 4-week open-label trial in 15 women, aged 16–56 years, with severe migraine and documented right to left shunt (RLS).

Results:

13/15 had >50% reduction or complete elimination of migraine symptoms. After completing the trial period, five responders remain on clopidogrel with ongoing benefit at 11.9 ± 4.5 months (6.5–20), one stopped clopidogrel because of side effects. Nine other responders underwent PFO closure and clopidogrel discontinuation. Eight of nine have had ongoing benefit.

Conclusions:

Clopidogrel may have a primary prophylactic role in migraine/RLS patients, but may also help select candidates who would benefit from PFO closure. A randomized clinical trial is being established.
Short- to Medium-term Outcomes After a Modified Broström Repair for Lateral Ankle Instability With Immediate Postoperative Weightbearing
Authors: Petrera Massimo , Dwyer Tim , Theodoropoulos John S. , Ogilvie-Harris Darrell J.
Published: April 2014

Background:

Anatomic techniques of ankle ligament repair have the advantage of restoring the anatomy and kinematics of the joint. This study presents a technique for anatomic reconstruction of the lateral ligament complex by way of lateral ligament advancement using suture anchors associated with immediate protected full weightbearing; 2- to 5-year clinical outcomes are reported.

Hypothesis:

This technique of providing an anatomic reconstruction with a secure fixation will enable early rehabilitation with immediate, protected weightbearing, with favorable outcomes.

Study Design:

Case series; Level of evidence, 4.

Methods:

Fifty-five patients with chronic lateral ankle instability who failed nonoperative management underwent modified Broström repair (lateral ligament fibular advancement) between 2005 and 2008. The anterior talofibular ligament and calcaneofibular ligament were released from the fibula and advanced using 2 double-loaded metallic suture anchors (3.5 mm). Full weightbearing in a walking boot was allowed from the first postoperative day. Patients were assessed preoperatively and at a minimum 2-year follow-up using the Foot and Ankle Outcome Score. Complication, failure (recurrent instability), and return-to-sport rates were also recorded.

Results:

Six patients (11%) were lost to follow-up, leaving a study group of 49 patients (23 men, 26 women). The mean age at the time of surgery was 25 years (range, 18-37 years), with a mean duration of symptoms of 1.8 years (range, 6 months to 5 years). The mean follow-up time was 42 months (range, 24-60 months). Significant improvement was seen in the Foot and Ankle Outcome Score from preoperatively to postoperatively (from 36 to 75.4, P < .001): the pain subscale improved from 35 to 75 ( P < .001), the symptom subscale from 29 to 77 ( P = .01), the function subscale from 45 to 77 ( P < .001), the function in sports and recreation subscale from 38 to 70 ( P < .001), and the foot and ankle–related quality of life subscale from 35 to 78 ( P < .001). No significant difference in range of motion with the contralateral side was seen ( P = .34). The failure rate was 6%, with 3 patients reporting residual instability after a traumatic retear. Two cases of superficial wound infection were seen. One case of temporary neurapraxia of the superficial peroneal nerve was observed. The return-to-sport rate was 94%.

Conclusion:

This study demonstrates that anterior talofibular ligament and calcaneofibular ligament advancement using suture anchor fixation is an effective procedure for the treatment of chronic lateral ankle instability and allows immediate weightbearing.
A Novel Mutation in the Mitochondrial DNA Cytochrome b Gene (MTCYB) in a Patient with Prader Willi Syndrome
Authors: Yiş Uluç , Ezgü Fatih Süheyl , Karakaya Pakize , Polat İpek , Arslan Nur , Çankaya Tufan , Bozkaya Özlem Giray , Kurul Semra Hız
Published: April 2014

In recent years, it has been suggested that defects in energy metabolism may accompany Prader Willi syndrome. Mutations in the mitochondrial cytochrome b gene have been commonly associated isolated mitochondrial myopathy and exercise intolerance, rarely with multisystem disorders. The authors describe a novel mutation (mt. 15209T>C) in mitochondrial cytochrome b gene in a 2-year-old girl with Prader-Willi syndrome with a clinical history of lactic acidosis attacks, renal sodium loss, hepatopathy, progressive cerebral atrophy, and sudden death. The authors suggest that atypical clinical findings in patients with Prader-Willi syndrome should direct the physician to search for a mitochondrial disease.
Touch Massage, a Rewarding Experience
Authors: Lindgren Lenita , Jacobsson Maritha , Lämås Kristina
Published: April 2014

This study aims to describe and analyze healthy individuals’ expressed experiences of touch massage (TM). Fifteen healthy participants received whole body touch massage during 60 minutes for two separate occasions. Interviews were analyzed by narrative analysis. Four identifiable storyline was found, Touch massage as an essential need, in this storyline the participants talked about a desire and need for human touch and TM. Another storyline was about, Touch massage as a pleasurable experience and the participants talked about the pleasure of having had TM. In the third storyline Touch massage as a dynamic experience, the informants talked about things that could modulate the experience of receiving TM. In the last storyline, Touch massage influences self-awareness, the participants described how TM affected some of their psychological and physical experiences. Experiences of touch massage was in general described as pleasant sensations and the different storylines could be seen in the light of rewarding experiences.
“Not Just a Theory”
Authors: Lamke Donna , Catlin Anita , Mason-Chadd Michelle
Published: April 2014

Purpose: The purpose of this study was to evaluate the effect of training nurses in Jin Shin Jyutsu® self-care methods and to correlate the training with measurement of the nurses’ personal and organizational stress and their perceptions of their caring efficacy for patients. Design: A quasi-experimental, pretest, posttest, and 30- to 40-day posttest design was used. Method: In all, 20 participants received three 2-hour Jin Shin Jyutsu self-care training sessions from a certified Jin Shin Jyutsu self-care trainer (who was also a registered nurse). The training took place over a 1-month period, and participants agreed to practice the self-care daily. Two study instruments, one measuring organizational and personal stress and the second measuring caring efficacy, were completed before the first training, after the last training, and 1 month after the trainings had been completed. Findings: Analysis of data from the Personal and Organizational Quality Assessment–Revised by paired t tests showed significant increases in positive outlook, gratitude, motivation, calmness, and communication effectiveness and significant decreases in anger, resentfulness, depression, stress symptoms, time pressure, and morale issues. Nurses reported less muscle aches, sleeplessness, and headaches. Analysis of the Coates Caring Efficacy Scale measures showed statistically significant increases in nurses’ caring efficacy in areas of serenity in giving care, tuning in to patients, relating to patients, providing culturally congruent care, individualization of patient care, ability to decrease stressful situations, planning for multiple needs, and creativity in care. Conclusions: This small study suggests that Jin Shin Jyutsu self-care may be a valuable tool for nurses, to decrease stress, both emotional and physical, and increase caring efficacy. Administrators may wish to invest in such a program, which may improve quality of care delivered. The Watson caring model, which reminds us that nurses who care for themselves and feel good about their work can better care for others, proved an accurate framework for this study.
Turbofan duct geometry optimization for low noise using remote continuous adjoint method
Authors: Qiu S , Liu H , Li WP
Published: April 2014

In this paper, a remote continuous adjoint-based acoustic propagation (RABAP) method is proposed for low noise turbofan duct design. The goal is to develop a set of adjoint equations and their corresponding boundary conditions in order to quantify the influence of geometry modifications on the amplitude of sound pressure at a near-field location. The governing equations for the 2.5D acoustic perturbation equation solver (APE) formulation for duct acoustic propagation is first introduced. This is followed by the formulation and discretization of the remote continuous adjoint equations based on 2.5D APE. The special treatment of the adjoint boundary condition to obtain sensitivities derivatives is also discussed. The theory is applied to acoustic design of an axisymmetric fan bypass duct for two different tone noise radiations. The 2.5D APE is further validated using comparisons to an experiment data of the TURNEX nozzle geometry. The implementation of the remote continuous adjoint method is validated by comparing the sensitivity derivative with that obtained using finite difference method. The result obtained confirms the effectiveness and efficiency of the proposed RABAP framework.
Contact stress and transmission errors under load of a modified curvilinear gear set based on finite element analysis
Authors: Chen Yi-Cheng , Lo Chien-Cheng
Published: April 2014

This study conducted a loaded tooth contact analysis of a modified curvilinear gear set with localized bearing contact based on finite element analysis. The contact stress and transmission errors under load were examined. First, a mesh generation program was developed according to the mathematical model of a curvilinear gear generated using a male fly cutter. A finite element model containing one contacting tooth pair was built, and the mesh density at the contact-sensitive area was adjusted to attain a reasonable finite element model for estimating the contact pressure. Adequate mesh density at the possible contact region predicted by tooth contact analysis was defined based on the theoretical Hertzian contact stress and the calculated contact ellipse. A finite element model containing five tooth pairs was developed and applied to examine the contact stress and transmission errors under load of the modified curvilinear gear set. Finally, numerical examples were provided to demonstrate the contact stress and transmission errors under load for various design parameters and loads.
Modelling life course blood pressure trajectories using Bayesian adaptive splines
Authors: Muniz-Terrera Graciela , Bakra Eleni , Hardy Rebecca , Matthews Fiona E , Lunn David , FALCon collaboration group
Published: April 2014

No single study has collected data over individuals’ entire lifespans. To understand changes over the entire life course, it is necessary to combine data from various studies that cover the whole life course. Such combination may be methodologically challenging due to potential differences in study protocols, information available and instruments used to measure the outcome of interest. Motivated by our interest in modelling blood pressure changes over the life course, we propose the use of Bayesian adaptive splines within a hierarchical setting to combine data from several UK-based longitudinal studies where blood pressure measures were taken in different stages of life. Our method allowed us to obtain a realistic estimate of the mean life course trajectory, quantify the variability both within and between studies, and examine overall and study specific effects of relevant risk factors on life course blood pressure changes.
Software Technology Park: Selecting the Contract Type and Contractor
Authors: Sheikh Rizwan A. , Jalil M. Naiman , Khan Khalid A.
Published: April 2014

The Punjab Information Technology Board (PITB) had been given the task of constructing a Software Technology Park (STP) by the Chief Minister of Punjab. The STP was a project of national importance with a budgeted cost of PKR 3.42 billion (USD 57 million), a seventeen storey tower and an aggressive construction timeline of eighteen months due to the national elections to be held in November 2007. The Chief Minister wanted to build a robust infrastructure and create a success story in the IT sector for the next elections. The upcoming elections also created a sense of urgency within the Punjab government to build an IT infrastructure in Punjab and show progress to the IT industry as well as the general public. Therefore, the Chairman PITB had to make two quick decisions if he wanted to meet the demanding schedule of the project. The decisions included: the selection of the contract type and the contractor for construction of the seventeen storey STP.
Software Technology Park: Contract Management
Authors: Sheikh Rizwan A. , Jalil M. Naiman , Khan Khalid A.
Published: April 2014

The construction contract for the seventeen storey STP building was awarded to China State Construction & Engineering Corporation (CSCEC) as it was the lowest and technically qualified bidder. The contract was awarded for a fixed fee of PKR 2.99 billion (USD 49.83 million) with a completion timeline of eighteen months. However, after nine months of construction, the contractor approached Punjab Information Technology Board (PITB) and asked for relaxation on high value items like elevators, escalators and building glass. The CSCEC asked PITB to allow them to change the country of origin (manufacturing) and brand name on these items while they ensured that all technical specifications would be met and there would be no compromise on quality. The dilemma Jasem faced was whether to allow CSCEC’s request or not. He also had to understand the consequences of whatever decision he made.
Pregabalin-Associated Heart Failure Decompensation in a Patient With a History of Stage I Heart Failure
Authors: Fong Taryn , Lee Audrey J.
Published: April 2014

Objective: To describe an elderly male patient with a prior history of New York Heart Association (NYHA) class I heart failure (HF) who presented with cardiac decompensation related to pregabalin therapy and to review the literature involving the effects of pregabalin in HF patients. Case Summary: An 84-year-old man with NYHA class I HF (left-ventricular ejection fraction between 45% and 50%) presented to the emergency department with acute HF decompensation approximately 10 days after initiation of pregabalin for the management of peripheral neuropathy. Discontinuation of pregabalin and administration of furosemide resulted in resolution of symptoms. Shortness of breath; facial, neck, and peripheral edema; and weight gain all improved within 2 days. Three months following discontinuation of furosemide and pregabalin, the patient remained stable without any recurring symptoms or progression in HF. Discussion: Pregabalin is associated with a 10% to 15% prevalence of peripheral edema and weight gain, with cases reported in patients both with and without HF. Whereas most reported HF exacerbations have occurred in patients with NYHA class II to IV HF, this case is one of the first to be reported in a patient with NYHA class I. According to the Naranjo probability scale (score of 4), it was possible that the patient’s HF symptoms were related to pregabalin. The mechanism of action of pregabalin-induced HF is unknown, but pregabalin has been shown to act as a calcium channel antagonist. Conclusion: Although further studies are needed, this case suggests that close monitoring of patients with NYHA class I HF should be considered when initiating pregabalin therapy.
Template-based modeling methodology of a virtual plant for virtual commissioning
Authors: Ko Minsuk , Park Sang C
Published: April 2014

This article presents a template-based modeling methodology for the effective construction of a virtual plant that can be used for the virtual commissioning of a programmable logic controller. For virtual commissioning, the corresponding virtual plant, consisting of virtual devices, is required to interact with the input and output symbols of a programmable logic controller. In other words, the behavior of a virtual device should be the same as that of the real device. Conventionally, discrete event systems specifications formalism has been used to represent the behavior of a virtual device. However, modeling using discrete event systems specifications formalism requires in-depth knowledge of simulation as well as significant amounts of time and effort. One of the key ideas of the proposed methodology is to provide a device template model representing the relations between the tasks of a device. The proposed template is very intuitive and can be used to generate a comprehensive behavior model of a virtual device. The proposed approach has been implemented and demonstrated for a robotic cell.
A Transdisciplinary Perspective on Hedonomic Sustainability Design
Authors: Fiore Stephen M. , Phillips Elizabeth , Sellers Brittany C.
Published: April 2014

The impact of climate change should be a key concern of those in the human factors/ergonomics (HF/E) discipline. Our specialized knowledge and expertise can be applied toward mitigating the effects of climate change. In this article, we unite two perspectives to illustrate how HF/E can more productively contribute to the research and practice of sustainability. First, we describe differing forms of cross-disciplinary research, with a particular focus on the notion of transdisciplinary research and the concept of hedonomic design. Second, we unite these ideas to illustrate how they provide a set of complementary concepts that can guide HF/E sustainability research.
Epithelioid Angiosarcoma Arising in an Adrenal Cortical Adenoma
Authors: Hendry Shona , Forrest Cynthia
Published: April 2014

Adrenal masses are common incidental imaging findings, with the majority comprising benign adrenal cortical adenomas. However, the differential diagnosis is extensive and includes both primary and secondary malignant lesions. Primary adrenal angiosarcomas are rare and often exhibit epithelioid morphology, which can present a diagnostic pitfall. We report an exceptional “incidentaloma” in a 60-year-old lady, which showed the features of a primary epithelioid angiosarcoma arising within an adrenal cortical adenoma. No other primary tumor was identified on extensive imaging. This unusual combined tumor has been reported only once before, to the best of our knowledge. The pattern of infiltration of the malignant endothelial cells raises the suggestion that the angiosarcoma arose from vascular elements of the adenoma.
Recurrent pseudocellulitis due to gemcitabine: Underrecognized and underreported?
Authors: Dasanu Constantin A , Bockorny Bruno
Published: April 2014

Pseudocellulitis has been previously described with the use of chemotherapy agent gemcitabine. This condition is thought to occur due to vascular toxicity and increased localized permeability of the skin capillaries. We report herein a case of recurrent pseudocellulitis due to gemcitabine in a patient with metastatic pancreatic cancer. We believe this condition is underreported and underrecognized. Furthermore, it may be misdiagnosed as cellulitis and inappropriately treated with systemic antibiotics. As the diagnosis is clinical and the condition is self-limited, referral to other specialists is usually not required. Awareness of gemcitabine-induced pseudocellulitis is important in order to reassure the patients, their families, and non-oncology providers and to avoid unnecessary (and often costly) diagnostic work-up.
Silent error detection in numerical time-stepping schemes
Authors: Benson Austin R , Schmit Sven , Schreiber Robert
Published: April 2014

Errors due to hardware or low-level software problems, if detected, can be fixed by various schemes, such as recomputation from a checkpoint. Silent errors are errors in application state that have escaped low-level error detection. At extreme scale, where machines can perform astronomically many operations per second, silent errors threaten the validity of computed results.

We propose a new paradigm for detecting silent errors at the application level. Our central idea is to frequently compare computed values to those provided by a cheap checking computation, and to build error detectors based on the difference between the two output sequences. Numerical analysis provides us with usable checking computations for the solution of initial-value problems in ODEs and PDEs, arguably the most common problems in computational science. Here, we provide, optimize, and test methods based on Runge–Kutta and linear multistep methods for ODEs, and on implicit and explicit finite difference schemes for PDEs. We take the heat equation and Navier–Stokes equations as examples. In tests with artificially injected errors, this approach effectively detects almost all meaningful errors, without significant slowdown.
Sexual fetishism in organizations: The case of journal list fetishism
Authors: Cluley Robert
Published: April 2014

Organizations can encourage their members to over-value means above ends. A case in point is the tendency among academics to over-value standardized ranking lists for academic journals at the expense of high quality research. To make sense of such seemingly perverse object choices, organizational researchers have turned to the concept of fetishism. However, organizational researchers have yet to consider how these fetishes are organized as sexual object choices—a strange omission given the expansive empirical and theoretical literature exploring fetishism as a sexual practice. Drawing a distinction between the fetishism of organizations and fetishism in organizations, the article seeks to redress this oversight.
Gay men in the performing arts: Performing sexualities within ‘gay-friendly’ work contexts
Authors: Rumens Nick , Broomfield John
Published: April 2014

Building on emerging research on ‘gay-friendly’ organizations, this article examines if and how work contexts understood and experienced as ‘gay-friendly’ can be characterized as exhibiting a serious breakdown in heteronormativity. Taking the performing arts as a research setting, one that is often stereotyped as ‘gay-friendly’, and drawing on in-depth interview data with 20 gay male performers in the UK, this article examines how everyday activities and encounters involving drama school educators, casters and peers are shaped by heteronormative standards of gay male sexuality. Adopting a queer theory perspective and connecting with an emergent queer theory literature in organization studies, one concern articulated in this article is that heteronormative constructions of gay male sexualities constrain participants’ access to work; suggesting limits to the abilities and roles gay men possess and are able to play. Another concern is that when gay male sexualities become normalized in performing work contexts, they reinforce organizational heteronormativity and the heterosexual/homosexual binary upon which it relies. This study contributes towards theorizing the heteronormative dynamics of ‘gay-friendly’ places of work, arguing that gay male sexualities are performatively instituted according to localized heteronormativities which reinforce contextually contingent, restrictive heteronormative standards of gay male sexuality which performers are encouraged to embody and perform both professionally and personally.
Bodyspace at the pub: Sexual orientations and organizational space
Authors: Riach Kathleen , Wilson Fiona
Published: April 2014

In this article we argue that sexuality is not only an undercurrent of service environments, but is integral to the way that these workspaces are experienced and negotiated. Through drawing on Sara Ahmed’s (2006a) ‘orientation’ thesis, we develop a concept of ‘bodyspace’ to suggest that individuals understand, shape and make meaning of work spaces through complex sexually-orientated negotiations. Presenting analysis from a study of UK pubs, we explore bodyspace in the lived experience of workplace sexuality through three elements of orientation: background; bodily dwelling; and lines of directionality. Our findings show how organizational spaces afford or mitigate possibilities for particular bodies, which simultaneously shape expectations and experiences of sexuality at work. Bodyspace therefore provides one way of exposing the connection between sexual ‘orientation’ and the lived experience of service sector work.
Effects of bearing clearance and supporting stiffness on performances of rotor-bearing system with multi-decked protuberant gas foil journal bearing
Authors: Lai Tianwei , Chen Shuangtao , Ma Bin , Zheng Yueqing , Hou Yu
Published: April 2014

The supporting stiffness and coulomb damping in a bearing play significant roles in the smooth operation of rotor-bearing system. The performance of multi-decked protuberant gas foil journal bearing is evaluated experimentally in a high-speed turboexpander. The effect of radial clearance on the bearing performance is analyzed based on the relationship between rotor speed and supply pressure in the speed-up and speed-down processes. The maximal speed of the 25 mm diameter rotor reached as high as 100 kr/min, and subsynchronous vibrations are suppressed in the tests. For the bearings with 0.05 mm protuberant foils, there will be thermal runaway problem with −20 µm clearance, while unstable operation appears with 80 µm clearance. For the bearing with 0.07 mm protuberant foil, the vibration amplitude is constrained within smaller amplitude due to stiffer supporting structure. The test results indicate that the bearing can operate stably under different gas film thickness and supporting stiffness, and that this kind of foil bearing can be applied in high-speed turbomachinery due to its stability and adaptability.
Implementation of integrated heterogeneous electronic electrocardiography data into Maharaj Nakorn Chiang Mai Hospital Information System
Authors: Khumrin Piyapong , Chumpoo Pitupoom
Published: April 2014

Electrocardiography is one of the most important non-invasive diagnostic tools for diagnosing coronary heart disease. The electrocardiography information system in Maharaj Nakorn Chiang Mai Hospital required a massive manual labor effort. In this article, we propose an approach toward the integration of heterogeneous electrocardiography data and the implementation of an integrated electrocardiography information system into the existing Hospital Information System. The system integrates different electrocardiography formats into a consistent electrocardiography rendering by using Java software. The interface acts as middleware to seamlessly integrate different electrocardiography formats. Instead of using a common electrocardiography protocol, we applied a central format based on Java classes for mapping different electrocardiography formats which contains a specific parser for each electrocardiography format to acquire the same information. Our observations showed that the new system improved the effectiveness of data management, work flow, and data quality; increased the availability of information; and finally improved quality of care.
Factors underlying male and female use of violent video games
Authors: Hartmann Tilo , Möller Ingrid , Krause Christina
Published: April 2014

Research has consistently shown that males play violent video games more frequently than females, but factors underlying this gender gap have not been examined to date. This approach examines the assumption that males play violent video games more because they anticipate more enjoyment and less guilt from engaging in virtual violence than females. This may be because males are less empathetic, tend to morally justify physical violence more and have a greater need for sensation and aggression in video game play than females. Results of a path model based on survey data of 444 respondents and using multi-step multiple mediation analyses confirm these assumptions. Taken together, the findings of this study shed further light on the gender gap in violent video game use.
Dissolving the dog: the home made video
Authors: Laurier Eric
Published: April 2014

Drawing on an ethnographic study of home-movie makers through a series of cuts between ‘clips’, this article inquires into what it is to produce videos of a companion animal, in fact, a really big dog, in and around the home. The final clip examines Richard Sennett’s misplaced critique of Hannah Ardent’s discussion of animal laborens and homo faber. Arendt’s two figures of human work are related to the production and purpose of home-movies of pets. The other series of clips provide a description of how an amateur editing technique is put to use and the modest aesthetic at work in doing so. The home-movie itself is examined through its site of production and the idea of craft (so important to both Sennett and Arendt), only gradually bringing the figure of the animal into focus. The article’s form plays off the disjunctures that we find across edit points in home-movies by having four distinct sections that do not correspond with the flow of conventional journal articles.
The smell of the Moon
Authors: Straughan Elizabeth R.
Published: April 2014

In a darkened room on Earth, an astronaut stands amongst a collection of moon rocks slowly and deliberately performing a maintenance task. With a grab stick in one hand and gas hose in another, he/she deploys the grab stick to pick up moon rocks spraying them, one by one, with the smell of the Moon. Titled Enter at Own Risk, this performance work is the creation of artist duo Hagen Betzwieser and Sue Corke who collaborate as WE COLONISED THE MOON. In this paper I consider the way in which the sense of smell has been deployed as an aesthetic object by this art duo and in so doing, unpack the qualities of smell that have traditionally made this a problematic sense with regards to its deployment within the space of the art gallery. These are spatial and temporal qualities that have been utilized by Betzwieser and Corke not only in the design of the installation space at Liverpool’s Foundation for Art and Creative Technology but also through the bringing together of maintenance practice and smell – the durational and the ephemeral – which has implications beyond the gallery space, imbuing the work with its critical edge.
Kinematic modelling of the weaving process applied to 2D fabric
Authors: Vilfayeau Jérôme , Crépin David , Boussu François , Soulat Damien , Boisse Philippe
Published: April 2014

A weaving process simulation of fabrics, used as fibrous reinforcements in composite applications, is presented in this article. The mechanical modelling of textile structures requires an accurate geometric representation of the woven elementary cell including complex interlacements of yarns and compactions. Using an explicit finite element solver, this paper proposes to mimic the kinematics in the weaving process of an industrial dobby loom in order to produce virtual textile samples whose geometry is driven by weaving loom parts. Different assumptions on the yarn geometrical and material law behaviour are initially taken from the literature to fit to the modelling of an E-glass yarn inserted in a 2D woven fabric. After several simulations, yarn parameters have been adapted to reproduce the observed cross-sectional shapes leading to a higher level of geometrical accuracy. The primary focus of the study has been on a 2D plain weave fabric with E-glass yarns. As a result, it can be observed that the geometry of the simulated yarns is quite similar to the coated samples achieved on real dobby loom using the proposed kinematic model.
Older adults fighting obesity with bariatric surgery: Benefits, side effects, and outcomes
Authors: Marihart Cindy L , Brunt Ardith R , Geraci Angela A
Published: April 2014

The aging population is growing exponentially worldwide. Associated with this greater life expectancy is the increased burden of chronic health conditions, many of which are exacerbated by the continued rise in obesity. In the US, the prevalence of obesity in adults aged 60 years and older increased from 23.6% to 37% in 2010.

Objectives:

This review examines bariatric surgery as a treatment option for obese adults > 60 years old. The most common types of weight-loss surgery are laparoscopic adjustable gastric banding, vertical sleeve gastrectomy, Roux-en-Y gastric bypass, and the duodenal switch.

Methods:

A comprehensive literature search found 349 articles that referred to bariatric surgery in older adults. Of these, 70 relevant articles on bariatric surgery for older adults were utilized for this article.

Results:

Weight-loss surgery procedures were found to be equally safe for both older adults and their younger counterparts. Pre-surgical psychological assessment is critical for positive outcomes for older adults. Benefits of bariatric surgery include a decrease in comorbidities, chronic disease risk, and medication use coupled with improved mobility and quality of life outcomes. Side effects include surgical failure, changes in psychological status, and increased physical and mental stress.

Conclusions:

Bariatric surgery can offer patients an effective and long-lasting treatment for obesity and related diseases. There does not appear to be any one bariatric procedure that is recommended for older adults, so individual needs should be taken into consideration when exploring options. Costs range from US$17,000 for laparoscopic procedures to US$26,000 for open gastric surgeries. Estimated savings start accruing within 3 months of surgery making bariatric surgery a serious cost saving consideration.
Avoiding Complications and Technical Variability During Arthroscopically Assisted Transtibial ACL Reconstructions by Using a C-Arm With Image Intensifier
Authors: Trentacosta Natasha , Fillar Allison Liefeld , Liefeld Cynthia Pierce , Hossack Michael D. , Levy I. Martin
Published: April 2014

Background:

Surgical reconstruction of the anterior cruciate ligament (ACL) can be complicated by incorrect and variable tunnel placement, graft tunnel mismatch, cortical breaches, and inadequate fixation due to screw divergence. This is the first report describing the use of a C-arm with image intensifier employed for the sole purpose of eliminating those complications during transtibial ACL reconstruction.

Purpose:

To determine if the use of a C-arm with image intensifier during arthroscopically assisted transtibial ACL reconstruction (IIAA-TACLR) eliminated common complications associated with bone–patellar tendon–bone ACL reconstruction, including screw divergence, cortical breaches, graft-tunnel mismatch, and improper positioning of the femoral and tibial tunnels.

Study Design:

Case series; Level of evidence, 4.

Methods:

A total of 110 consecutive patients (112 reconstructed knees) underwent identical IIAA-TACLR using a bone–patellar tendon–bone autograft performed by a single surgeon. Intra- and postoperative radiographic images and operative reports were evaluated for each patient looking for evidence of cortical breeching and screw divergence. Precision of femoral tunnel placement was evaluated using a sector map modified from Bernard et al. Graft recession distance and tibial α angles were recorded.

Results:

There were no femoral or tibial cortical breaches noted intraoperatively or on postoperative images. There were no instances of loss of fixation screw major thread engagement. There were no instances of graft-tunnel mismatch. The positions of the femoral tunnels were accurate and precise, falling into the desired sector of our location map (sector 1). Tibial α angles and graft recession distances varied widely.

Conclusion:

The use of the C-arm with image intensifier enabled accurate and precise tunnel placement and completely eliminated cortical breach, graft-tunnel mismatch, and screw divergence during IIAA-TACLR by allowing incremental adjustment of the tibial tunnel and knee flexion angle. Incremental adjustment was essential to accomplish this. Importantly, a C-arm with image intensifier can be used with any ACL reconstruction that incorporates tunnels in the technique, with the expectation of increase in accuracy and precision and the elimination of common complications.

Clinical Relevance:

The use of an image intensifier during transtibial ACL reconstruction will substantially reduce the common complications associated with the procedure and improve both accuracy and precision of tibial and femoral tunnel placement. Use of an image intensifier unit is generalizable to an individual surgeon’s preferences for graft choices and drilling techniques and will be especially valuable when the intercondylar architecture is altered from injury, time, or prior surgery.
Learning from ‘Scrap’ about Late Bronze Age Hoarding Practices: A Biographical Approach to Individual Acts of Dedication in Large Metal Hoards of the Carpathian Basin
Authors: Dietrich Oliver
Published: April 2014

Hoard finds appear throughout the European Bronze Age with distinct chronological and chorological peaks. While there is some consensus on seeing hoards as an expression of cultic behaviour, the large ‘scrap metal' hoards in particular still provoke interpretations as raw material collected for recycling. With socketed axes whose sockets were intentionally filled with deliberately fragmented metalwork, Hansen (1996–1998) has pointed out a group of finds that could be crucial to a better understanding of ‘scrap’ hoards. Using the finds from the Carpathian Basin as a case study, a dual biographical approach is applied to this group. A close look at the complex use-life of the objects themselves, as well as an attempt at re-integrating them into the local history of hoarding, leads to the conclusion that they constitute single acts of dedication in larger contexts. “Scrap hoards’” can thus be understood as long-term accumulations of votive objects and can be integrated into the social practice of Bronze Age hoarding.
Runx1 exon 6–related alternative splicing isoforms differentially regulate hematopoiesis in mice
Authors: Komeno Yukiko , Yan Ming , Matsuura Shinobu , Lam Kentson , Lo Miao-Chia , Huang Yi-Jou , Tenen Daniel G. , Downing James R. , Zhang Dong-Er
Published: April 2014

Key Points

Human RUNX1a orthologs are only found in primates. Alternative splicing of Runx1 involving exon 6 affects the pool size of hematopoietic stem cells.
The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2)
Authors: Nayak Lalitha , Shi Hong , Atkins G. Brandon , Lin Zhiyong , Schmaier Alvin H. , Jain Mukesh K.
Published: April 2014

Key Points

Transcription factor KLF2 is a critical determinant of vascular thrombosis. The antithrombotic effect noted with bortezomib is KLF2 dependent.
Accelerating the scoring module of mass spectrometry-based peptide identification using GPUs
Authors: Li You , Chi Hao , Xia Leihao , Chu Xiaowen
Published: April 2014

Background

Tandem mass spectrometry-based database searching is currently the main method for protein identification in shotgun proteomics. The explosive growth of protein and peptide databases, which is a result of genome translations, enzymatic digestions, and post-translational modifications (PTMs), is making computational efficiency in database searching a serious challenge. Profile analysis shows that most search engines spend 50%-90% of their total time on the scoring module, and that the spectrum dot product (SDP) based scoring module is the most widely used. As a general purpose and high performance parallel hardware, graphics processing units (GPUs) are promising platforms for speeding up database searches in the protein identification process.

Results

We designed and implemented a parallel SDP-based scoring module on GPUs that exploits the efficient use of GPU registers, constant memory and shared memory. Compared with the CPU-based version, we achieved a 30 to 60 times speedup using a single GPU. We also implemented our algorithm on a GPU cluster and achieved an approximately favorable speedup.

Conclusions

Our GPU-based SDP algorithm can significantly improve the speed of the scoring module in mass spectrometry-based protein identification. The algorithm can be easily implemented in many database search engines such as X!Tandem, SEQUEST, and pFind. A software tool implementing this algorithm is available at http://www.comp.hkbu.edu.hk/~youli/ProteinByGPU.html
Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection
Authors: Wang Jia-Xing , Yi Yong , Li Yi-Wei , Cai Xiao-Yan , He Hong-Wei , Ni Xiao-Chun , Zhou Jian , Cheng Yun-Feng , Jin Jian-Jun , Fan Jia , Qiu Shuang-Jian
Published: April 2014

Background

Sirtuin 3 (Sirt3), one of the seven Sirtuins family members, plays critical roles in the progression of multiple cancer types. However, its role in the prognosis of hepatocellular carcinoma (HCC) has not yet been investigated systematically.

Methods

The correlation of Sirtuins expression with prognosis of HCC was determined by immunohistochemistry (IHC) in a large HCC patient cohort (n = 342). Expression of Sirt3 in tumoral and peritumoral tissues of HCC patients were further determined by western blotting (WB).

Results

IHC and WB studies both showed a decreased expression of Sirt3 in tumoral tissues compared with peritumoral tissues (P = 0.003 for IHC, P = 0.0042 for WB). Decreased expression of Sirt3 in both tumoral and peritumoral tissues was associated with increased recurrence probability and decreased overall survival rate by univariate analyses (intratumoral Sirt3: P = 0.011 for TTR, P = 0.001 for OS; peritumoral Sirt3: P = 0.017 for TTR, P = 0.023 for OS), the prognostic value was strengthened by multivariate analyses (intratumoral Sirt3: P = 0.031 for TTR, P = 0.001 for OS; peritumoral Sirt3: P = 0.047 for TTR, P = 0.031 for OS). Intratumoral Sirt3 also showed a favorable prognostic value in patients with BCLC stage A (TTR, P = 0.011; OS, P < 0.001). In addition, we found that IHC studies of other sirtuin members showed a decreased expression of Sirt2, Sirt4 and Sirt5 and an increased expression of Sirt1, Sirt6 and Sirt7 in intratumoral tissues compared with peritumoral tissues. In contrast to Sirt3, other members did not showed a remarkable correlation with HCC prognosis.

Conclusions

Down-regulation of intratumoral and peritumoral Sirt3 were both associated with poor outcome in HCC, moreover, intratumoral Sirt3 was a favorable prognostic predictor in early stage patients.