bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Injectable Nerve Stimulation Electrode Placed on the Dorsal Root Ganglion Using an Extravertebral Approach: A Feasibility Study in Cadavers
Authors: Billet Bart
Published: January 2025

BACKGROUND: Dorsal root ganglion stimulation (DRGS) is an established method for treating persistent and severe pain conditions. However, performing DRGS has significant challenges. Current DRGS systems are expensive, hindering accessibility for many patients and health care systems. Additionally, placing DRGS devices requires specialized training in epidural techniques and lead anchoring methods. Technical and financial requirements also limit the clinical applicability and availability of DRGS.

OBJECTIVES: This study evaluated the feasibility of a new method for rapidly delivering near- DRG stimulation in human cadavers. The method involves a fluoroscopy-guided transforaminal approach using a fully implantable, injectable electrode, and its associated delivery system.

STUDY DESIGN: A human cadaver feasibility study.

SETTING: A cadaver laboratory.

METHODS: In this study, 3 anesthesiologist pain physicians received training on the injectable electrode device and delivery system using spine phantom models. They then applied the device’s associated implantation techniques to 2 adult male cadavers. In the first cadaver, a single injectable electrode was placed near the left L2 lumbar DRG. In the second cadaver, injectable electrodes were placed near the left L1 and L2 DRG levels, and a benchmark DRGS device was installed at the left L1 level using fluoroscopic guidance. A careful anatomical dissection was then performed for each implanted device.

RESULTS: The stimulating contacts of the injectable electrodes were accurately positioned within one mm of the DRG at the lumbar L1 and L2 levels in both cadavers. The distances of both the injectable lead and benchmark DRGS device at the L1 level were measured as one mm from the posterior aspect of the DRG.

LIMITATIONS: The findings of this study are based on anatomical examinations of a limited number of human cadavers and may not fully represent living human anatomy.

CONCLUSIONS: To our knowledge, this feasibility cadaver study is the first of its kind to examine the accuracy and efficiency of a fluoroscopy-guided transforaminal approach to place injectable electrodes near the DRG. These promising results suggest that this method could be a viable alternative to existing DRGS techniques, warranting further investigation into its clinical potential.

KEY WORDS: Cadaveric study, technical report, anatomical feasibility, dorsal root ganglion stimulation, peripheral nerve stimulation, chronic pain, neuropathic pain, injectable electrode
Revisitando solidaridad: Perspectivas en un nuevo orden mundial
Authors: Montiel Mendez Oscar Javier , Sirazetdinova Miliausha
Published: January 2025

Solidarity as a social construct has begun to take up new momentum in the social sciences. It has enormous potential to impact all of its areas, especially management. In this article, we, guest editors, introduce various perspectives that shed light on how to apply to different theoretical and empirical concerns, which were part of the special issue dedicated to this topic in Telos. The purpose of this study is to analyze the directions and approaches in contemporary studies of social solidarity. The authors use analysis of secondary source and theoretical analysis of sociological, economic, and managerial concepts. Another classification of sources divide those regarding theoretical issues of joint society, and exploring solidarization practices. The research findings show that traditional concepts of social systems’ integration and collective satisfaction of needs neighbor with numerous contexts arising around solidarity as a human right to collective protection of group interests, an ethical obligation to help those who are in need, acceptance of the Other, contributing to global integration.
Asthma-related deaths in Brazil: data from an ecological study
Authors: da Rocha Oliveira Cardoso1 Amanda , Galvão Ferreira1 Anna Carolina , Fouad Rabahi1 Marcelo
Published: January 2025

Objective: The aim of this study was to present epidemiological data on hospitalizations and deaths related to asthma in Brazil over the past 11 years. Methods: An ecological study was conducted on asthma-related hospitalizations and mortality in Brazil from 2013 to 2023, using data extracted from the Department of Informatics of the Brazilian Unified Health System and the Mortality Information System. Results: Asthma-related deaths showed an increasing trend during the analyzed period. A surge in deaths was observed in 2022 compared to 2014 (difference between means = 56.08 ± 19.7; 95% CI = 15.2-96.9). The mean number of deaths was higher among females, with their rate remaining stable, while the rate for males increased. Individuals aged >60 years accounted for approximately 65% of all asthma-related deaths from 2013 to 2023, with a strong direct correlation observed between age and the number of deaths, regardless of sex. During the same period, the total number of asthma-related hospitalizations in Brazil showed a declining trend, decreasing from 134,322 in 2013 to 87,707 in 2023. Conclusion: Over the past 11 years, asthma-related deaths have increased in Brazil, with the majority occurring among females. Older individuals accounted for most asthma-related deaths, and a positive correlation was observed between age and the number of deaths.
Effectiveness of Phoenix Dactylifera and Oxytocin Massage on Prolactin Levels in Breastfeeding Mothers in Palembang City
Authors: Aprilina Aprilina , Ocktariyana Ocktariyana , Lestari Dian
Published: January 2025

Exclusive breastfeeding is essential in the growth and development of babies and improves maternal health. Exclusive breastfeeding can reduce infant mortality rates; of the 3 thousand infant deaths in Indonesia, 10 million deaths of children aged less than 5 years in the world each year can be prevented by exclusive breastfeeding. The hormones that play a role in breastfeeding mothers are prolactin and oxytocin. The research aimed to look at the effectiveness of oxytocin massage and Phoenix dactylifera in increasing the levels of the hormone prolactin in breastfeeding mothers. The research was a Quasi Experiment with a Post Test only design, a sample of 30 people divided into three groups. Phoenix Dactylifera intervention, oxytocin massage intervention, and control without treatment. The research was conducted at TPMB Palembang city. Analysis using the Shapiro-Wilks test for data homogeneity using Levene's test (pmore than 0.05) and the One Way ANOVA test compared the means of the three groups. The results showed no significant differences between the three groups where the ρ value was more than 0.05. The conclusion is that there is nothing more effective in increasing prolactin hormone levels than giving Phoenix dactylifera and oxytocin massage because it is thought to be caused by many influencing factors, including age, education, nutritional intake, and maternal parity.
Customer Loyalty Analysis on Valuation of Price, Location, Facilities, and Service Standards with the Structural Equation Modeling Method - Partial Least Squares (SEM-PLS)
Authors: Poniman  , Thoriq Fitrah , Mandati Sri Amalia , Batutah Moh Arif , Utomo Yitno
Published: January 2025

Abstract - The world of business and industry, including the culinary industry, is rapidly developing in this modern era. Business owners have to compete in an increasingly tight situation. Compared to previous studies, this study is newer because it uses more variables. This quantitative study used 60 samples. SmartPLS software version 3.0 is used to perform the analysis with SEM. Outer model, inner model, mediation, and hypothesis tests are carried out. The results of the validity test show that the data is valid. The filling factor value is more than 0.7 and the AVE value is more than 0.5. In contrast, reliability tests show the reliability values of composites and Cronbach's alpha, which are also greater than 0.7 and are considered reliable. From the histothesis analysis carried out, it can be concluded that; The consumer choice variable has a significant positive impact on customer loyalty, the facility and infrastructure variable has a significant positive impact on consumer choice, the facility and infrastructure variable has a significant positive impact on customer loyalty, the business location variable has a significant positive impact on consumer choice, the business location variable has a negative impact on customer loyalty, the price assessment variable has an impact negative on consumer choice, the price assessment variable has a significant positive impact on customer loyalty, the service standard variable has a significant negative impact on customer choice and customer loyalty. These results show the importance of paying attention to these variables in business strategy.
PENYULUHAN TENTANG MANFAAT DAUN SIRIH CINA (Peperomia pellucida L.) SEBAGAI ANTIOKSIDAN DI SMAN 1 STM HILIR KABUPATEN DELI SERDANG
Authors: Simorangkir Delisma Marsauli
Published: January 2025

Secara umum apoteker semakin dituntut untuk mengembangkan diri dalam bidang industri farmasi, salah satunya adalah industri kosmetik. Salah satunya adalah sediaan kosmetik berbahan dasar herbal sebagai antioksidan dan antibakteri terutama yang berkhasiat untuk kulit wajah. Metode kegiatan yang dilakukan antara lain dengan melakukan survei, merencanakan tempat untuk kegiatan pelatihan pengabdian kepada masyarakat. Melalui kegiatan penyuluhan kesehatan masyarakat ini siswa-siswi SMAN 1 STM HILIR dapat menjaga dan merawat kesehatan wajah khususnya kecantikan kulit dan juga mampu memberikan informasi kepada masyarakat dengan memberikan informasi dan edukasi tentang kebersihan dan juga memberikan pengetahuan serta menambah pemahaman tentang manfaat daun sirih cina yaitu digunakan sebagai masker antioksidan baik secara tradisional maupun modern. Kegiatan penyuluhan kesehatan masyarakat (PKM) bagi siswa-siswi SMAN 1 STM HILIR Kabupaten Deli serdang.
KEGIATAN PENGABDIAN KEPADA MASYARAKAT SOSIALISASI DAN EDUKASI PENGGUNAAN KOSMETIK BERBAHAYA PADA REMAJA DI SMA NEGERI 13 MEDAN
Authors: Sulasmi Sulasmi
Published: January 2025

Abstract
Wellbeing could be a state of physical, mental, and social well-being, and not as it were free from malady but too living productively. The sort of wellbeing specialist may be a pharmaceutical specialist, namely a drug specialist. A drug specialist could be a proficient who has information and abilities within the field of drug store and has the specialist and obligation to carry out pharmaceutical errands. Beauty care products are materials utilized exterior the human body, such as skin, hair, nails, lips, outside genital organs, teeth, and mouth, particularly for cleaning, scenting, progressing appearance and body odor. Recently, numerous perilous components and chemicals in beauty care products; mercury, retinoic corrosive, hydroquinone, and rhodamine B. Side impacts from the utilize of perilous makeup can be facial skin harm, carcinogenicity, kidney disappointment, and teratogenicity. Utilize "Cek KLIK" to check the security of makeup.
INTRODUCTION TO BASIC MICROBIOLOGY CONCEPTS IN THE PREVENTION OF INFECTIOUS DISEASES at YAPIM BIRU-BIRU PRIVATE HIGH SCHOOL
Authors: Fahdi Firdaus , Sari Herviani
Published: January 2025

Infectious diseases, caused by microorganisms such as viruses, bacteria, parasites, and fungi, pose a significant public health challenge, particularly in tropical countries like Indonesia. These microorganisms can exist harmlessly within the human body but may become pathogenic under certain conditions. Schools, due to their dense population and frequent interpersonal interactions, are potential hotspots for the transmission of infectious diseases. The lack of awareness about pathogenic microorganisms and simple hygiene measures often exacerbates the spread of preventable infections. To address this, a community engagement program was conducted at YAPIM Biru-Biru Private Senior High School/Vocational School to enhance students' understanding of microbiology and its role in preventing infectious diseases. The objectives included increasing awareness about pathogenic microorganisms, educating on the importance of environmental hygiene, and teaching simple preventive measures to reduce infection risks in school settings. The program involved three phases: preparation, implementation, and feedback. Activities included a pre-test to assess baseline knowledge, a presentation on basic microbiology concepts, a post-test to eval_uate learning outcomes, and a Q&A session to reinforce understanding. The results showed improved participant knowledge, behavioral changes such as frequent handwashing and mask usage when unwell, and positive responses from participants, indicating the program's success. This initiative highlights the importance of regular educational programs to foster consistent hygiene practices and prevent infectious diseases in schools.
Should DMOs Use Incentives to Attract Conferences? Exploring the views of professional conference organizers on DMO use of financial incentives to secure association conferences
Authors: Delaney Emma
Published: January 2025

Evidence suggests that factors influencing choice of destination for a conference have changed and the effectiveness and sustainability of traditional approaches to securing conferences such as the offer of financial incentives by destinationmanagement organizations (DMOs), has been questioned. Incentives, such as venue discounts, are used to attract association conferences to a destination but this widely accepted industry practice remains scarcely discussed in scientific publications. Therefore, there is a renewed need to understand site selection from the perspective of professional conference organizers (PCO) and such research will be valuable to the growing number of competing destinations and to the policy makers that support them. This research reports on a qualitive inquiry involving 12 elite PCOs designed to specifically explore the influence of financial incentives onsite selection. This research makes an important contribution to the theoretical discourse on destination competitiveness and is of practical value to DMOs and policy makers.
Implementasi Prinsip Ekonomi Syariah Dalam Pengelolaan Bisnis Mikro Di Kota Bandung
Authors: Paul Wina , Ismawati RR. , Mardiana S. Yana , Vivianita Wilda , Lisviana Sherly
Published: January 2025

Bisnis mikro sering kali menghadapi berbagai tantangan seperti keterbatasan akses pembiayaan, rendahnya literasi keuangan, dan kurangnya pemahaman tentang prinsip-prinsip syariah. Pengabdian ini dapat mengidentifikasi tantangan-tantangan tersebut dan menawarkan solusi praktis untuk mengatasinya. Lembaga keuangan syariah memainkan peran penting dalam mendukung bisnis mikro melalui pembiayaan yang sesuai dengan prinsip syariah. Tujuan pengabdian ini ialah memberikan pendampingan kaitannya dengan implementasi prinsip ekonomi syariah dalam pengelolaan bisnis mikro di Kota Bandung. Metode pelaksanaan pengabdian kepada masyarakat yang digunakan ialah pendampingan. Hasil pengabdian menunjukan, implementasi prinsip ekonomi syariah dalam bisnis mikro berkontribusi pada peningkatan kesejahteraan sosial dan ekonomi. Bisnis yang dikelola dengan prinsip syariah lebih berkelanjutan, etis, dan mendapatkan kepercayaan lebih dari masyarakat, yang pada gilirannya meningkatkan dukungan komunitas dan pertumbuhan bisnis. Meskipun banyak kemajuan yang dicapai, beberapa tantangan masih perlu diatasi, termasuk kurangnya pemahaman yang mendalam tentang prinsip ekonomi syariah, keterbatasan akses pembiayaan syariah di daerah terpencil, infrastruktur digital yang belum merata, dan regulasi yang perlu ditingkatkan untuk mendukung pengembangan ekonomi syariah. Program ini tidak hanya meningkatkan pemahaman dan literasi keuangan syariah, tetapi juga memberikan akses pembiayaan, mendukung penggunaan teknologi, dan membentuk jaringan dukungan yang kuat
Interaction Between Monetary Policies and Stock Market Development in Nigeria: An Econometrics Analysis
Authors: Udeorah Sylvester , Oladosu Isaac Olubiyi , Odiche Williams
Published: January 2025

This study explored the interplay between monetary policies and stock market development in Nigeria, focusing on key monetary policy variables such as interest rate, money supply, exchange rate, and liquidity ratio. Stock market development was measured through market capitalization. Anchored in Monetarism theory and the Efficient Market Hypothesis, the research utilized annual time series data spanning from 1990 to 2023, sourced from the Central Bank of Nigeria (CBN) statistical bulletin and Nigeria Exchange Group (NGX). Analytical methods included descriptive statistics, the Augmented Dickey-Fuller (ADF) unit root test, and the Autoregressive Distributed Lag (ARDL) approach. Results revealed that interest rates negatively and significantly impact stock market capitalization, while broad money supply and exchange rates exhibit positive and significant effects. Conversely, liquidity ratio was found to have a negative but non-significant impact on market capitalization. The study concluded that monetary policy serves as a critical stabilization tool influencing stock market development in Nigeria. It recommended that the Central Bank of Nigeria adopt a balanced approach in setting the Monetary Policy Rate (MPR) to effectively manage market expectations.
Survival of colorectal cancer patients based on mismatch repair gene mutation status
Authors:   Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Adijaya Tri Indra Putra , Bakri Syakib ,   Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Makbul Aman A. ,   Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Minhajat Rahmawati ,   Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Luthfi Parewangi AM ,   Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Alfian Zainuddin A. ,   Department of Public Health and Community Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Published: January 2025

Background. According to the Global Cancer Observatory 2020, colorectal cancer was responsible for 19.3 million new cases and 10 million deaths worldwide. One of the main mechanisms underlying the pathogenesis of colorectal cancer involves the presence of mismatch repair (MMR) gene mutations. Guidelines recommend adjusting colorectal cancer treatment based on MMR gene mutation status. This approach combines targeted therapy with conventional chemotherapy regimens. Methods. The methodology focused on research from the past five years. Retrospective cohort studies were chosen due to their high level of evidence in prognostic research. A literature search was conducted using the keywords “Colorectal Cancer”, “Microsatellite Instability or Mismatch Repair”, “Gene Mutation”, and “Survival or Prognosis” in three electronic databases: PubMed, ScienceDirect, and Scopus. Results. Analysis revealed that colorectal cancer with deficient MMR (dMMR) status was associated with better survival outcomes compared to proficient MMR (pMMR) status in stage II and III colorectal cancer. Adjuvant chemotherapy showed greater efficacy for stage III colorectal cancer with dMMR status. Furthermore, combining adjuvant chemotherapy with targeted therapy significantly improved the survival of patients with dMMR status. However, stage IV colorectal cancer with dMMR/MSI did not show any prognostic advantage, despite a lower risk of distant metastasis. Conclusion. Colorectal cancer with pMMR status exhibited lower survival rates compared to those with dMMR status. Patients with stage II and III colorectal cancer and dMMR/MSI status benefited from neoadjuvant chemotherapy and targeted therapy, demonstrating improved disease-free survival compared to those with pMMR/MSS status.
Use of acetyl-L-carnitine in diabetic peripheral neuropathy: A systematic review and meta-analysis
Authors:   Department of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India, Balamurugan Yohidha , Ananthakumar PK ,   Department of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India, Mohan Subash ,   Department of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India, Chand Utham ,   Department of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
Published: January 2025

Background. Diabetic peripheral neuropathy (DPN) represents a prevalent and distressing complication within the diabetic community, often leading to significant morbidity. The therapeutic value of acetyl-L-carnitine (ALC) for DPN has been investigated across various studies with mixed results. This systematic review and meta-analysis consolidates existing research to ascertain the efficacy of ALC in ameliorating the symptoms of DPN. Methods. Fifteen articles that satisfied the inclusion requirements for the meta-analysis were found after a thorough assessment of the literature was conducted. The majority of these investigations were randomized controlled trials that compared ALC medication against either no treatment at all or a placebo in patients with DPN. The sources for literature retrieval were research databases such as the Cochrane Central Register of Controlled Trials, EMBASE, and PubMed. Neural pain, sensory function, and nerve conduction velocities were among the outcome measurements. The Cochrane Risk of Bias tool was utilized to evaluate bias, and the effect sizes were computed with the assistance of random-effects models. Results. Aggregated findings from the included studies indicated a statistically significant improvement in neuropathic symptoms and nerve function among participants receiving ALC compared with those given a placebo. Moreover, these improvements were particularly notable in patients presenting with severe neuropathy at baseline. Conclusions. The evidence synthesized in this review and meta-analysis points to ALC's effectiveness in enhancing clinical outcomes for patients with DPN, endorsing its inclusion in the treatment regimen for this condition. Nonetheless, the observed heterogeneity among studies and the potential biases underscore the necessity for further methodologically rigorous studies. Such future research should aim to delineate ALC's long-term therapeutic profile and elucidate its underlying mechanisms within the context of diabetic neuropathy.
Pengaruh Media Gambar Interaktif terhadap Minat Belajar Siswa pada Pembelajaran IPA di Kelas IV SD
Authors: Putri Vanessa , Sari Mawar
Published: January 2025

Minat sangat besar pengaruhnya terhadap hasil belajar, karena apabila bahan pelajaran yang dipelajari tidak sesuai dengan minat, siswa tidak akan belajar dengan baik sebab tidak menarik baginya. Dapat di simpulkan minat belajar adalah rasa lebih suka dan ketertarikan pada satu hal atau aktivitas, tanpa ada yang menyuruh. Rendahnya Minat belajar siswa pada pembelajaran Ilmu pengetahuan alam disebabkan karena kurangnya penggunaan media pembelajaran yang sesuai dengan kebutuhan peserta didik. Adapun tujuan dari penelitian ini yakni untuk mengetahui pengaruh Media Gambar Interaktif Terhadap Minat Belajarr Siswa Pada Pembelajaran IPA di Kelas IV SD Bina Taruna Jaya Medan. Penelitian ini menggunakan metode Penelitian kuantitatif model eksperiment dengan subjek yakni siswa kelas IV SD yang berjumlah 24 siswa. Hasil dalam penelitian ini menunjukan jika persentase Minat belajar siswa mengalami peningkatan pada setiap siklusnya yakni pada prasiklus 58,33% lalu pada siklus I adalah 75% dan 96% pada siklus II. Sehingga dapat disimpulkan bahwa terdapat peningkatan Minat belajar mata Pelajaran IPA siswa kelas IV setelah menggunakan Media Gambar Interaktif
Enhancing Sustainable Tourism In East Nusa Tenggara Through Air Transport Connectivity
Authors: Prasetya Oce
Published: January 2025

Air transport connectivity is a critical element in supporting tourism in archipelagic regions like East Nusa Tenggara (NTT). This article employs a Systematic Literature Review (SLR) approach to examine key variables in sustainable tourism development, including flight frequency, airport infrastructure, tourist accessibility, and environmental conservation. The analysis reveals that improved air transport connectivity significantly contributes to achieving several Sustainable Development Goals (SDGs), such as SDG 9 (Sustainable Infrastructure), SDG 11 (Sustainable Communities), SDG 13 (Climate Action), and SDG 15 (Biodiversity Conservation). This article provides strategic recommendations for inclusive and environmentally friendly air connectivity development to support tourism growth in NTT.
Implementasi Pasal 4 Hurup F Peraturan Pemerintah Nomor 94 Tahun 2021 Tentang Disiplin Pegawai Negeri Sipil (PNS) di Lingkungan Pemerintahan Kota Tasikmalaya Perspektif Siyasah Dusturiyah
Authors: Sahril Sidik  , Ridwan Eko Prasetyo  , Budi Tresnayadi
Published: January 2025

Penelitian ini bertujuan untuk meneliti permasalahan terkait implementasi Pasal 4 Hurup F Peraturan Pemerintah Nomor 94 Tahun 2021 tentang disiplin pegawai negeri Sipil di lingkungan pemerintahan Kota Tasikmalaya dari perspektif siyasah dusturiyah. Fokus penelitian ini yaitu terhadap bagaimana kebijakan  yang diambil oleh pemerintah Kota Tasikmalaya serta implikasi yang di timbulkan dari kebijakan tersebut. Selain itu, Penelitian ini mengguanakan perspektif siyasah dusturiyah untuk menganalisis bagaimana prinsip-prinsip hukum Islam dapat diintegrasikan dalam kebijakan publik. Penelitian menggunakan metode kualitatif dengan  pendekatan yuridis empiris. Data diperoleh melalui berbagai metode yaitu observasi, wawancara, dokumentasi dan studi pustaka. Data di analisa dengan teknik interpretasi mengungkap esensi ontologis, epistemologis, dan aksiologis yang terkait dengan tujuan penelitian. Penelitian ini menemukan bahwa kebijakan pemerintah Kota Tasikmalaya terhadap penerapan Pasal 4 Hurup F Peraturan Pemerintah Nomor 94 Tahun 2021 sudah terlaksana dengan baik walaupun belum sepenuhnya optimal, mengingat masih terdapat beberapa pegawai yang masih melakukan pelanggaran disiplin jam masuk kerja. Implikasi yang di timbulkan dari kebijakan tersebut adalah peningkatan kesadaran di kalangan pegawai negeri sipil mengenai pentingnya disiplin dalam menjalankan tugas. Dari hasil penelitian ini mengemukakan bahwa pegawai negeri sipil di pemerintah Kota Tasikmalaya belum menerapkan prinsip  kemaslahatan dan keadilan yang seharusnya menjadi landasan dalam setiap pelayanan publik.
Magnetic Flux Emergence and Solar Eruptions in Partially Ionized Plasmas
Authors: Chouliaras Georgios , Archontis V.
Published: January 2025

We have performed 3D MHD simulations to study the effect of partial ionization in the process of magnetic flux emergence in the Sun. In fact, we continue previous work, and we now focus (1) on the emergence of the magnetic fields above the solar photosphere and (2) on the eruptive activity that follows the emergence into the corona. We find that in the simulations with partial ionization (PI), the structure of the emerging field consists of arch-like field lines with very little twist since the axis of the initial rising field remains below the photosphere. The plasma inside the emerging volume is less dense, and it is moving faster compared to the fully ionized (FI) simulation. In both cases, new flux ropes (FR) are formed due to reconnection between emerging field lines, and they eventually erupt in an ejective manner toward the outer solar atmosphere. We are witnessing three major eruptions in both simulations. At least for the first eruption, the formation of the eruptive FR occurs in the low atmosphere in the FI case and at coronal heights in the PI case. Also, in the first PI eruption, part of the eruptive FR carries neutrals in the high atmosphere for a short period of time. Overall, the eruptions are relatively faster in the PI case, while a considerable amount of axial flux is found above the photosphere during the eruptions in both simulations.
Family socioeconomic differences among children living with overweight and obesity in North Macedonia
Authors: Stamenova Aleksandra , Wallace Lorraine Silver , Mihajlova Katerina , Dimitrievska Ljubica , Spiroski Igor
Published: January 2025

Globally, the prevalence of overweight and obesity is increasing among children and adolescents. Halting the rise in obesity is a significant challenge because of the complex interplay of factors and influences. We aimed to explore the role of family socioeconomic status (SES) indicators in relation to overweight and obesity prevalence rates among primary school children in North Macedonia. Materials and methods: Data were collected on a nationally representative sample of children and their parent(s)/caregiver(s) participating in the 6th round of World Health Organization (WHO)-European Childhood Obesity Surveillance Initiative (COSI) in North Macedonia. Every child had their height and weight objectively measured and their family sociodemographic and SES data were obtained through a self-reported record form by their parent(s)/caregiver(s). According to COSI reporting, responses on three SES indicators (parental educational attainment, parental employment status and family-perceived wealth) were categorized in levels for data analysis. Overweight and obesity rates were estimated based on 2007 WHO growth references. Pearson’s χ2-tests, corrected with the Rao-Scott method, were used to test differences in overweight and obesity across various subgroups. Results: The sample consisted of primarily native-born children (97.3%) and parents (mothers - 96.2%; fathers - 97.6%), living in urban areas (66.9%), in two-parent families (84.9%) and spoke Macedonian at home (59.8%). The majority of children lived in families with low to medium SES level. Prevalence of overweight was 30.5% [95% CI: 28.5-32.7], whilst of obesity 14.1% [95% CI: 12.3-16.0]. There were no significant differences observed across family SES indicators in overweight or obesity rates.  Conclusion: Our findings contribute towards reporting on family SES among children living with overweight and obesity to better understand and address potential obesity risk factors. Future research should focus on exploring family SES within the long-term context of children’s health-related behaviours.
Stromatogenesis and angiogenesis, two essential processes of tumor invasion in malignant epithelial neoplasms - A brief review of planocellular skin carcinoma
Authors: Tasheva Ljubica , Kostadinova-Petrova Irena , Stojkovska Natasha , Mitevska Elida , Kakasheva-Mazhenkovska Lena
Published: January 2025

Each neoplasm creates its own unique micro-environment in which the tumor grows and modifies. Although majority of host cells in the neoplasm stroma have obligatory tumor suppression ability, the stroma changes during the malignant process and even promotes growth, invasion and metastasis. The genetic changes that occur during cancer evolution, driven by malignant cells, lead to changes in the stroma of the host. At the same time angiogenesis occurs, and formation of new vascular net from the existing normal capillaries. The stroma in the neoplasm does not only give mechanical support to the tumor, but also provides metabolically rich and active environment where the cancer cells survive and multiply. It also contributes to tumor growth and through the newly formed vascular pathways enables further guidance to the circulation, so that the four features of the cancers are achieved: migration, invasion, angiogenesis and metastasis. The understanding of the molecular events in the process of stromatogenesis and angiogenesis is essential for clinical research.
Ciliated vulvar cyst in a 13-year-old girl- case report
Authors: Sima Aneta , Naunova Vesna , Simeonova-Krstevska Slagana , Dabeski Drage , Jovcheski Lazo , Risteski Toni , Krsteska Blagica
Published: January 2025

Vulvar cysts are rare, mostly benign lesions in childhood, originating from Miller's embryonic tissue and associated with progesterone action. The interior of the cysts is lined with columnar epithelium with cilia. They can be asymptomatic until they reach a size that causes heviness and pressure on the surrounding tissue and aesthetic deformity of the vulva. Case report: A 13-year-old girl presented with a large elongated cystic structure originating from the right labia majora of the vulva, with a length of about 20 cm, without significant symptoms, except for discomfort in the external genitalia. The cyst was surgically removed and the histopathological findings confirmed the existence of a ciliary vulvar cyst, originating from Miller's structures. After the operation, the cosmetic result was excellent and the young patient felt relieved. Conclusion: Vulvar cysts are a rare finding in childhood and puberty, but they can also reach large sizes. The treatment is surgical excision, which provides a cure, correction of the normal anatomy of the vulva, and histological confirmation of the diagnosis.
Robotic solutions for post-stroke recovery – literature review
Authors: Gocevska Marija , Gjerakaroska-Savevska Cvetanka , Nikolikj-Dimitrova Erieta , Koevska Valentina , Mitrevska Biljana , Kalchovska Biljana , Manoleva Maja , Gechevska Daniela
Published: January 2025

Stroke stands as a widespread and severe health concern worldwide, often resulting in profound motor and cognitive impairments. Its impact is particularly pronounced in the Republic of  North Macedonia, posing significant social and economic challenges. Beyond acute-phase treatments like medication and surgery, rehabilitation emerges as a pivotal component of stroke management. Robotic technology offers distinct advantages over conventional physical, occupational, and speech therapies, increasingly becoming a preferred option in post-stroke recovery. By integrating rehabilitation robots, not only does the burden on healthcare professionals decrease, but also the outlook for stroke patients improves. In this review, we provide a concise examination of the role played by therapeutic robots in the rehabilitation of individuals post-stroke. Our focus will encompass outlining the fundamental distinctions among various robotic rehabilitation devices and assessing the merits and drawbacks of employing robotic rehabilitation specifically for lower extremity rehabilitation.
Pediatric Echinococcosis: diagnosis, urgent surgical intervention, and treatment – case report
Authors: Memeti Shaban , Sulejmani Haris , Risteski Toni , Cokleska-Shuntov Natalija , Racaj Anila , Ljumani-Bakiu Njomza , Kamilovski Marijan , Gjuric Sanja , Selmani Rexhep , Rushiti Qemal
Published: January 2025

Echinococcus tapeworms cause human echinococcosis, which causes hydatid cysts, most commonly in the liver and lungs but also in other organs. Delays in symptom onset can lead to diagnostic issues, especially in children. Pediatric cases are rare and often lead to unintentional diagnoses. Living in a rural area increases risk. Imaging and serological testing are essential for diagnosis. This case is rare since it involves pediatric echinococcosis. Children rarely get echinococcosis, and symptoms are often vague; thus, diagnosis is mainly by accident. Case report: A 10-year-old female child developed symptoms and signs such as tachycardia, fever, and facial urticaria. On the first clinical examination, classic signs of an acute abdomen were present, indicating a possible abdominal emergency. Laboratory results showed significantly high levels of inflammatory markers, including CRP and WBC, indicating an active inflammatory process, most likely caused by infection or tissue injury. Imaging examinations, particularly a contrast CT scan of the abdomen, revealed two burst liver cysts in the peritoneal cavity, confirming the diagnosis of echinococcal cysts in the liver. We undertook an urgent surgical intervention to address the burst cysts and avert potential complications like peritonitis or sepsis. Post-operative treatment included constant monitoring of the patient's condition, antibiotic and antihelminthic medication to control infection, pain management, and supportive measures to help with recovery. Echinococcosis in children manifests as nonspecific symptoms, which often leads to a rare suspicion and coincidental diagnosis. Echinococcosis is often considered a possible cause of stomach discomfort. The standard treatment for echinococcosis usually involves a combination of antiparasitic medication and surgical removal of the cyst.
La mesure de la performance dans les start-ups : Quels enseignements pour le contrôle de gestion en entreprise ?
Authors: Endenich Christoph , Becker Sebastian D.
Published: January 2025

Cet article présente une analyse empirique des systèmes de mesure de performance dans le domaine de l’entrepreneuriat. À partir d’entretiens, d’observations et d’analyses documentaires, nous constatons que, dans un contexte d’incertitude élevée, de ressources restreintes et d’abondance de données, les start-ups procèdent à une forte hiérarchisation de leurs priorités. Plus précisément, elles ont recours à un très petit nombre d’indicateurs de haut niveau axés sur les résultats (centrés sur le client), communément appelés North Star Metrics dans la littérature spécialisée. Dans ce cadre, nous élaborons le concept de priorisation radicale, qui consiste pour une start-up à privilégier délibérément certaines données de mesure de la performance au détriment d’autres données. De plus, notre réflexion théorique attribue le recours répandu aux North Star Metrics dans la pratique entrepreneuriale à leur caractère performatif (Revellino et Mouritsen, 2015) et à leur rôle d’objet-frontière (Star et Griesemer, 1989). Nos résultats soulèvent des implications pratiques pour les entreprises établies qui peuvent s’inspirer des pratiques entrepreneuriales afin d’améliorer leurs propres systèmes de mesure de performance.
Article 2. Le monde selon Bunge : de la méthode au modèle à la réalité
Authors: Robillard Jean
Published: January 2025

Deux idées centrales sont défendues dans cet article. La première concerne les liens entre les concepts de matérialisme émergentiste et de réalisme critique dans la métaphysique bungéenne. Je défends la thèse que le réalisme critique bungéen doit intégrer épistémologiquement celui de matérialisme afin de se développer en tant que doctrine méthodologique. J’y analyse ce que je considère être les fondements de la méthode de la construction de cette même métaphysique, soit l’affirmation du postulat de l’extériorité du monde concret et son rôle dans la méthode en question. La seconde thèse a pour objet une analyse de cette méthode au moyen de l’étude que j’y fais des concepts ontologiques bungéens d’objet, de substance et de propriétés objectales. Je compare ensuite cette méthode à certains aspects de la philosophie des mathématiques et en particulier au rôle attribué dans cette même philosophie à la méthode axiomatique en tant que méthode de construction théorique et de preuve. Je conclus en une certaine circularité de l’argument qui justifie le réalisme critique à partir du postulat ontologique de l’extériorité du monde concret.
Article 3. Sur les types de problèmes rencontrés en science, en technologie et dans les professions : fondements d’une politique scientifique
Authors: Marone Luis
Published: January 2025

La science, la technologie et les professions forment un système de fortes interactions. Pourtant, ces activités s’attaquent à différents types de problèmes qui nécessitent différentes solutions. Les problèmes qui aiguillonnent la recherche scientifique et technologique demeurent insuffisamment résolus ou non résolus, donc leurs possibles solutions doivent être inventées (c.-à-d. qu’elles sont partiellement ou totalement originales) et, par conséquent, elles doivent être testées contre la réalité par les chercheurs avant de les considérer comme vraies ou utiles. Par contre, les problèmes qui aiguillonnent une investigation professionnelle sont déjà résolus ou une solution partielle est disponible sous la forme d’un protocole technique. Cette solution est appliquée avec prudence sans être testée (c’est-à-dire que le professionnel suppose que la solution fonctionne parce qu’elle a déjà été mise à l’épreuve par les chercheurs). De plus, la science et la technologie s’attaquent à des problèmes inverses non résolus, ce qui permet l’avancement radical des connaissances par de véritables innovations. Une politique scientifique fondée sur une distinction claire entre les activités créatives et les activités routinières (c.-à-d. une politique respectueuse de la créativité) offre à la société la possibilité d’un développement économique et intégral à valeur ajoutée.
Article 6. Critique bungéenne de la réflexion de Meillassoux sur les mathématiques
Authors: Orensanz Martín
Published: January 2025

Quentin Meillassoux est l’un des principaux philosophes français d’aujourd’hui. Son premier livre, Après la finitude. Essai sur la nécessité de la contingence (2006, traduit en anglais en 2008), est déjà un classique. Il comporte une préface de son ancien mentor, Alain Badiou. L’un des principaux objectifs de Meillassoux est de réhabiliter la distinction entre qualités premières et qualités secondes, typique des philosophies prékantiennes. Plus précisément, il affirme que les mathématiques sont capables de révéler les qualités premières de tout objet : « Tout ce qui de l’objet peut être formulé en termes mathématiques, il y a sens à le penser comme propriété de l’objet en soi. » Nous allons utiliser la philosophie mathématique de Bunge pour remettre en question l’hypothèse précédente.
Article 11. Les lumières de Mario Bunge : pour la méthode
Authors: Baillargeon Normand , Roy Jean-René
Published: January 2025

Ce texte est le fruit d’une collaboration entre un astrophysicien, Jean-René Roy, et un philosophe de l’éducation, Normand Baillargeon. Ils ont en commun d’avoir été marqués par la fréquentation des œuvres de Mario Bunge, auxquelles ils attachent un grand prix, sur un plan personnel, d’abord, mais aussi, et c’est ce qu’ils veulent rappeler dans ces pages : parce qu’ils estiment que les œuvres de Bunge contribuent de manière extrêmement forte et positive à rendre plus salubre la vie de l’esprit, en enrichissant notre intellect et en luttant contre diverses formes troublantes d’obscurantisme qui y sévissent parfois, notamment dans les domaines familiers aux deux auteurs.
L’enseignement de la littératie numérique pour la formation à une citoyenneté numérique : une étude exploratoire
Authors: Coste Jimmy , Brunel Magali
Published: January 2025

Le numérique et la place qu’il occupe dans nos sociétés emportent des évolutions et des enjeux qui ne peuvent être circonscrits à un domaine particulier tant ils abondent différentes sphères, dont l’enseignement qui sera l’objet de nos réflexions. La présence du numérique dans les échanges et interactions sociales met en évidence la nécessité de compétences spécifiques permettant de mieux maîtriser ses différents aspects. Ces compétences se retrouvent au sein du concept de littératie numérique. À partir de l’analyse des premières données issues d’une étude qualitative, nous interrogeons l’enseignement de ces compétences de la littératie numérique dans le premier degré en relation avec la formation à une citoyenneté numérique. En particulier nous mettons en évidence des manifestations d’apprentissage particulières à ce nouvel objet à enseigner ainsi que des gestes d’enseignement spécifiques.
« Je ne sais pas trop comment m’y prendre... » : les enseignants Lansad face aux défis de la traduction automatique
Authors: Molle Nicolas , Hamza Anissa , Nassau Guillaume
Published: January 2025

L’arrivée d’outils de traduction automatique (OTA) de plus en plus performants à l’université devrait mener l’ensemble des acteurs de la communauté universitaire à une réflexion sur leurs implications pédagogiques. Une recherche initiale, menée sur les représentations des apprenants et leurs utilisations des outils, a permis de mettre en lumière un manque de formation chez le public étudiant. Pour compléter ce premier état des lieux, nous avons mené une enquête auprès d’enseignants de langue du secteur Lansad (Langues pour spécialistes d’autres disciplines). L’analyse des résultats a permis de dégager des tendances sur la connaissance de ces outils, sur leur intégration dans les pratiques pédagogiques et sur la vision qu’ont les enseignants de la traduction automatique. Enfin, l’exploitation des données recueillies met en lumière une incertitude quant à l’avenir du métier d’enseignant de langue à l’ère de la traduction automatique.
Pour un apprentissage actif de la grammaire à travers des outils numériques multimodaux
Authors: Araújo Sílvia , Hannachi Radia
Published: January 2025

Dans le cadre de cet article, nous présenterons les résultats d'une expérience pédagogique menée à l'Université Bretagne Sud (Lorient, France) avec des étudiants de première année de licence en langues étrangères appliquées (LEA), dont la langue maternelle est le français. L'objectif de cette expérience était d'introduire les concepts de grammaire française à travers une méthodologie active en quatre étapes : i) mener une recherche documentaire sur le point grammatical choisi, ii) présenter les résultats de la recherche sous forme d'une infographie, iii) créer un podcast lié à l'infographie, et iv) élaborer un questionnaire sur la plateforme d'apprentissage Kahoot à soumettre aux autres étudiants du groupe. Pour faciliter ce processus, nous avons utilisé l'espace de travail collaboratif Padlet pour rassembler les différents contenus produits à chaque étape. Les étudiants ont été encouragés à utiliser divers outils numériques pour développer leurs compétences métalinguistiques ainsi que d'autres compétences transversales telles que l'autonomie, la littératie numérique et la coopération. Afin d'évaluer l'impact de cette approche multimodale sur l'assimilation des contenus grammaticaux dans leur langue maternelle, nous avons demandé aux 74 participants impliqués dans l'expérience de réaliser les actions suivantes : produire un texte narratif d'environ 350 mots en début de semestre, en réponse à un déclencheur, et passer un test diagnostique sur les points de grammaire à aborder en classe tout au long du semestre ; passer un test de vérification de l'assimilation des points de langue traités à la fin du semestre et produire un autre texte narratif pour vérifier l'application correcte des connaissances grammaticales à l'écrit. De plus, un questionnaire final a été utilisé pour évaluer l'expérience pédagogique mise en place. Cette proposition nous semble intéressante à plusieurs égards, car elle ouvre de nouvelles perspectives quant à l'intégration des outils numériques dans l'enseignement et l'apprentissage des langues, en particulier dans le traitement de la grammaire et son impact sur l'écriture.