bluuebunny/crossref_metadata_2025 huggingface dataset:
Post-Buckling Spring Vibration Isolator Using Silicone Gel Column: A Theoretical and Experimental Study
Authors: Yang Ji-Hou , Yang Xiao-Dong , Han Qing-Kai , Liu Jin-Guo
Published: November 2021

Based on the design of a post-buckling silicone gel column (SGC), a novel type of low-frequency vibration isolator is presented, and the vibration isolation performance of this isolator is studied by combining theoretical analysis and experimental verification. The stiffness characteristics of the post-buckling SGC are derived, and its recovery force curves with different parameters are analyzed using two kinds of elliptic integral functions. Displacement transmissibility is formulated using harmonic balance method (HBM), and the influences of the excitation amplitude, damping ratio, SGC section diameter, and Young’s modulus are discussed in terms of the transmissibility. The performance of the SGC system is verified through a series of experimental studies based on the developed experimental prototype. The result shows that the proposed post-buckling spring vibration isolator has a good vibration isolation effect, especially in the low-frequency domain, which may provide a feasible novel design idea for a low-frequency vibration isolator.
Numerical and Experimental Study of the Blade Profile of a Savonius Type Rotor Implementing a Multi-Blade Geometry
Authors: Gallo Luis A. , Chica Edwin L. , Flórez Elkin G. , Obando Felipe A.
Published: November 2021

In the present study, the implementation of multi-blade profiles in a Savonius rotor was evaluated in order to increase the pressure in the blade’s intrados and, thus, decrease motion resistance. The geometric proportions of the secondary element were determined, which maximized the rotor’s performance. For this, the response surface methodology was used through a full factorial experimental design and a face-centered central composite design, consisting of three factors, each with three levels. The response variable that was sought to be maximized was the power coefficient (CP), which was obtained through the numerical simulation of the geometric configurations resulting from the different treatments. All geometries were studied under the same parameters and computational fluid dynamics models through the ANSYS Fluent software. The results obtained through both experimental designs showed a difference of only 1.06% in the performance estimates using the regression model and 3.41% when simulating the optimal proportions geometries. The optimized geometry was characterized by a CP of 0.2948, which constitutes an increase of 10.8% in its performance compared to the profile without secondary elements and of 51.2% compared to the conventional semicircular profile. The numerical results were contrasted with experimental data obtained using a wind tunnel, revealing a good degree of fit.
Intelligent Prediction of Aeroengine Wear Based on the SVR Optimized by GMPSO
Authors: Zheng Bo , Gao Feng , Ma Xin , Zhang Xiaoqiang
Published: November 2021

In order to predict aeroengine wear accurately and automatically, as a predictor, support vector regression (SVR) was optimized by means of particle swarm optimization (PSO). The guided mutation strategy of PSO (GMPSO) is presented herein to determine the proper structure parameters of an SVR, as well as the embedding dimensions of the training samples. The guided mutation strategy was able to increase the diversity of particles and improve the probability of finding the global extremum. Furthermore, single-step and multi-step prediction methods were designed to meet different accuracy requirements. A prediction comparison study on spectral analysis data was carried out, and the contrast experiments show that compared with SVR optimized by means of a traditional PSO, a neural network and an auto regressive moving average (ARMA) prediction model, the SVR optimized by means of the GMPSO approach produced prediction results not only with higher accuracy, but also with better consistency.
Microphysical Characteristics and Environmental Isotope Effects of the Micro-Droplet Groups under the Action of Acoustic Waves
Authors: Bai Wenwen , Wei Jiahua , Shi Yang , Zhao Zhifeng , Li Qiong
Published: November 2021

Acoustics can cause particles/droplets to agglomerate in the air medium, thereby accelerating gravity sedimentation. To assess the microphysical characteristics and environmental isotope effects of micro-droplet groups under the action of acoustic waves, an air chamber experimental platform was established, and 100 groups of controlled experiments were conducted. The characteristic particle size, size spectrum, isotope values, corresponding linear relationships with hydrogen and oxygen, and d values were analyzed. The isotope exchange equation between the micro-droplet groups and environmental water vapor inside the air chamber was investigated. The results showed that the peak size values of the micro-droplet groups increased under the action of acoustic waves. The characteristic particle size (D90) showed a “trigger effect” with the acoustic operation with a positive deviation in the size spectrum and isotope exchange between the micro-droplet groups and environmental water vapor. The relative variations in theoretical values for different sedimentation conditions were consistent with those of the experimental results. Environment isotopes could be used to trace the acoustic agglomeration process of micro-droplets in the future.
Cutaneous Vascular Neoplasms of Uncertain Biological Behavior
Authors: McCollum Kasey J. , Al-Rohil Rami N.
Published: November 2021

Neoplasms of uncertain biological behavior present physicians with a genuine conundrum in practice. Cutaneous vascular neoplasms within this category are exceedingly rare, possessing significant gaps and uncertainty in many facets of clinical practice. Firstly, lesions were selected for review based on their categorization as indeterminate behavior, indicating the potential for local recurrence and rarely metastasize. After identification of the target lesions, a comprehensive review of the literature using national databases produced several landmark studies and case series regarding these neoplasms. Limiting the review to only cutaneous limited tumors narrowed the pool of studies; however, quite a large sum of papers remained. Examination of each paper yielded beneficial results on diagnosing, effective treatments, follow-up findings, and prognosis for each indeterminate lesion discussed. Overall, the literature search combined the molecular, histologic, immunohistochemical, surgical strategies to develop an up-to-date and comprehensive framework to guide physicians when encountering such lesions. The tumors reviewed include: kaposiform hemangioendothelioma, endovascular papillary angioendothelioma, pseudomyogenic hemangioendothelioma, retiform hemangioendothelioma, epithelioid hemangioendothelioma, and composite hemangioendothelioma.
Ultrastructural Variations of Antennae and Labia Are Associated with Feeding Habit Shifts in Stink Bugs (Heteroptera: Pentatomidae)
Authors: Li Xinyu , Tian Li , Li Hu , Cai Wanzhi
Published: November 2021

The family Pentatomidae (stink bugs) is one of the largest groups in Heteroptera, containing many important pests and natural enemies. They exhibit highly diversified feeding habits and related structural modifications, but the key morphological characteristics associated with feeding habit radiation remain unclear. In the current study, we address this question by analyzing morphological variations of feeding related organs. We compare the ultrastructures of antennae and mouthparts across the chosen 17 species in Pentatomidae, representing both plant feeders and predators from four subfamilies. A strong association between ultrastructural adaptation and feeding habit transition has been revealed. The long, sharp, and hook-like mandibular teeth and maxillary barbs are exclusively present in predatory Pentatomidae, suggesting their tight association with the shift of feeding habit from phytophagy to predation. Significant differences between phytophagous and predatory species are also found in antennal and labial sensilla types and arrangements, implying their important function in food selection. Our data identify a series of key morphological structures associated with feeding habit variations among stink bugs, which will facilitate future studies on adaptive evolution of feeding habits, utilization, and population control of economic species in Pentatomidae as well as in other heteropteran lineages.
Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves
Authors: Pompili Elena , De Franchis Valerio , Giampietri Claudia , Leone Stefano , De Santis Elena , Fornai Francesco , Fumagalli Lorenzo , Fabrizi Cinzia
Published: November 2021

In contrast with the brain and spinal cord, peripheral nerves possess a striking ability to regenerate after damage. This characteristic of the peripheral nervous system is mainly due to a specific population of glial cells, the Schwann cells. Schwann cells promptly activate after nerve injury, dedifferentiate assuming a repair phenotype, and assist axon regrowth. In general, tissue injury determines the release of a variety of proteases which, in parallel with the degradation of their specific targets, also activate plasma membrane receptors known as protease-activated receptors (PARs). PAR1, the prototypical member of the PAR family, is also known as thrombin receptor and is present at the Schwann cell plasma membrane. This receptor is emerging as a possible regulator of the pro-regenerative capacity of Schwann cells. Here, we summarize the most recent literature data describing the possible contribution of PAR1 and PAR1-activating proteases in regulating the regeneration of peripheral nerves.
Differential Cytokine-Induced Responses of Polarized Microglia
Authors: Chauhan Priyanka , Sheng Wen S. , Hu Shuxian , Prasad Sujata , Lokensgard James R.
Published: November 2021

The role of select pro- and anti-inflammatory mediators in driving microglial cell polarization into classically (M1), or alternatively, (M2) activated states, as well as the subsequent differential responses of these induced phenotypes, was examined. Expression of PD-L1, MHC-II, MHC-I, arginase 1 (Arg-1), and inducible nitric oxide synthase (iNOS) was assessed using multi-color flow cytometry. We observed that both pro- and anti-inflammatory mediators induced PD-L1 expression on non-polarized microglia. Moreover, IFN-γ stimulated significant MHC class I and II expression on these cells. Interestingly, we observed that only IL-4 treatment induced Arg-1 expression, indicating M2 polarization. These M2 cells were refractory to subsequent depolarization and maintained their alternatively activated state. Furthermore, PD-L1 expression was significantly induced on these M2-polarized microglia after treatment with pro-inflammatory mediators, but not anti-inflammatory cytokines. In addition, we observed that only LPS induced iNOS expression in microglial cells, indicating M1 polarization. Furthermore, IFN-γ significantly increased the percentage of M1-polarized microglia expressing iNOS. Surprisingly, when these M1-polarized microglia were treated with either IL-6 or other anti-inflammatory cytokines, they returned to their non-polarized state, as demonstrated by significantly reduced expression of iNOS. Taken together, these results demonstrate differential responses of microglial cells to mediators present in dissimilar microenvironments.
Assessment of Timber Roof Structures before and after Earthquakes
Authors: Perković Nikola , Stepinac Mislav , Rajčić Vlatka , Barbalić Jure
Published: November 2021

The global objective of sustainable development has been greatly directed toward the preservation of existing structures. Therefore, condition assessment and reconstruction of existing timber structures have been gaining importance in recent times. This is particularly evident on timber roofs whose elements are exposed to degradation, either because of rheological effects or due to the direct influence of moisture and biological factors. In case of accidental events, such as an earthquake, the question of the structure’s condition is essential for the condition of the entire building. In order to prove the load-bearing capacity and serviceability of existing structures, as well as to check the need for reconstruction, it is necessary to define crucial parameters that are influencing the condition of materials, elements, and systems. Although there are many non destructive testing methods, the frequency and scope of their use, as well as the decision-making approach, have not been defined. In the paper, non-destructive and semi-destructive methods frequently used for timber structures are explained. A systematic review of criteria to be used in the assessment of load-bearing timber structures in a seismic active area was the main objective of this paper as well as the illustration of non-destructive and semi-destructive test methods through a case study involving roof construction of a hundred-year-old building in Zagreb, Croatia. Pre- and post-earthquake inspection was made. The overall condition of the roof structure after two significant earthquakes can be assessed as satisfactory given that the observed system is a large-span and massive roof structure. The presented results and identification of typical damages after the earthquake are presented in order to facilitate policy makers and for the future implementation of development strategies in the renovation of the city.
The Influence of Casein Protein Admixture on Pore Size Distribution and Mechanical Properties of Lime-Metakaolin Paste
Authors: Brzyski Przemysław , Suchorab Zbigniew , Łagód Grzegorz
Published: November 2021

Biopolymers based on proteins are applied in the building materials technology to modify and improve their selected properties. These polymers are designed as natural admixtures that improve the workability of materials. Casein is an example of a protein-based organic polymer. It is a protein obtained from cow’s milk. The paper aimed at investigating the prospects of enhancing the strength properties of a binder prepared on a basis of metakaolin and hydrated lime. The mix was modified with powdered technical casein at 0.5%, 1%, 3%, and 5% as a partial replacement for the binder mix by mass. The study involved investigating the effect of the applied natural admixture on the flexural and compressive strengths, as well as pore size distribution. The average pore diameter decreased in the recipes with casein in the amount of 0.5% and 1%, while it increased when the amount of casein equaled 3% and 5%. Only the 0.5% casein admixture caused a decrease in the total porosity. The results show a clear dependence of the strength parameters on porosity. The admixture of casein significantly increased the flexural strength of the pastes, and decreased the compressive strength. The highest increase in flexural strength (by 205.7%) was caused by the admixture of 0.5% casein, while the greatest decrease in compressive strength (by 28%) was caused by the 3% casein admixture. The flexural strength was enhanced, i.a., due to the improved adhesion and mutual bonding of lime particles, resulting from the application of a sticky admixture. No notable difference was indicated during carbonation by the phenolphthalein test. The lime binder is characterized by a slow setting process and low mechanical strength. The results of the research showed the possibility of improving the flexural strength using small amounts of natural admixture, which may broaden the scope of application of this binder.
Quantification of Cancer-Developing Idiopathic Pulmonary Fibrosis Using Whole-Lung Texture Analysis of HRCT Images
Authors: Liang Chia-Hao , Liu Yung-Chi , Wan Yung-Liang , Yun Chun-Ho , Wu Wen-Jui , López-González Rafael , Huang Wei-Ming
Published: November 2021

Idiopathic pulmonary fibrosis (IPF) patients have a significantly higher risk of developing lung cancer (LC). There is only limited evidence of the use of texture-based radiomics features from high-resolution computed tomography (HRCT) images for risk stratification of IPF patients for LC. We retrospectively enrolled subjects who suffered from IPF in this study. Clinical data including age, gender, smoking status, and pulmonary function were recorded. Non-contrast chest CT for fibrotic score calculation and determination of three dimensional measures of whole-lung texture and emphysema were performed using a promising deep learning imaging platform. The results revealed that among 116 subjects with IPF (90 non-cancer and 26 lung cancer cases), the radiomics features showed significant differences between non-cancer and cancer patients. In the training cohort, the diagnostic accuracy using selected radiomics features with AUC of 0.66–0.73 (sensitivity of 80.0–85.0% and specificity of 54.2–59.7%) was not inferior to that obtained using traditional risk factors, such as gender, smoking status, and emphysema (%). In the validation cohort, the combination of radiomics features and traditional risk factors produced a diagnostic accuracy of 0.87 AUC and an accuracy of 75.0%. In this study, we found that whole-lung CT texture analysis is a promising tool for LC risk stratification of IPF patients.
A Systematic Review of Cost-Effectiveness Analyses of Novel Agents in the Treatment of Multiple Myeloma
Authors: Seefat Maarten R. , Cucchi David G. J. , Dirven Stijn , Groen Kaz , Zweegman Sonja , Blommestein Hedwig M.
Published: November 2021

Background: Novel therapies for multiple myeloma (MM) promise to improve outcomes but are also associated with substantial increasing costs. Evidence regarding cost-effectiveness of novel treatments is necessary, but a comprehensive up-to-date overview of the cost-effectiveness evidence of novel treatments is currently lacking. Methods: We searched Embase, Medline via Ovid, Web of Science and EconLIT ProQuest to identify all cost-effectiveness evaluations of novel pharmacological treatment of MM reporting cost per quality-adjusted life year (QALY) and cost per life year (LY) gained since 2005. Quality and completeness of reporting was assessed using the Consolidated Health Economic Evaluation Reporting Standards. Results: We identified 13 economic evaluations, comprising 32 comparisons. Our results show that novel agents generate additional LYs (range: 0.311–3.85) and QALYs (range: 0.1–2.85) compared to backbone regimens and 0.02 to 1.10 LYs and 0.01 to 0.91 QALYs for comparisons between regimens containing two novel agents. Lifetime healthcare costs ranged from USD 60,413 to 1,434,937 per patient. The cost-effectiveness ratios per QALY gained ranged from dominating to USD 1,369,062 for novel agents compared with backbone therapies and from dominating to USD 618,018 for comparisons between novel agents. Conclusions: Cost-effectiveness ratios of novel agents were generally above current willingness-to-pay thresholds. To ensure access, cost-effectiveness should be improved or cost-effectiveness ratios above current thresholds should be accepted.
Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis
Authors: Wende Tim , Kasper Johannes , Prasse Gordian , Glass Änne , Kriesen Thomas , Freiman Thomas M. , Meixensberger Jürgen , Henker Christian
Published: November 2021

Background: Reduced temporal muscle thickness (TMT) has been discussed as a prognostic marker in IDH-wildtype glioblastoma. This retrospective multicenter study was designed to investigate whether TMT is an independent prognostic marker in newly diagnosed glioblastoma. Methods: TMT was retrospectively measured in 335 patients with newly diagnosed glioblastoma between 1 January 2014 and 31 December 2019 at the University Hospitals of Leipzig and Rostock. The cohort was dichotomized by TMT and tested for association with overall survival (OS) after 12 months by multivariate proportional hazard calculation. Results: TMT of 7.0 mm or more was associated with increased OS (46.3 ± 3.9% versus 36.6 ± 3.9%, p > 0.001). However, the sub-groups showed significant epidemiological differences. In multivariate proportional hazard calculation, patient age (HR 1.01; p = 0.004), MGMT promoter status (HR 0.76; p = 0.002), EOR (HR 0.61), adjuvant irradiation (HR 0.24) and adjuvant chemotherapy (HR 0.40; all p < 0.001) were independent prognostic markers for OS. However, KPS (HR 1.00, p = 0.31), BMI (HR 0.98, p = 0.11) and TMT (HR 1.06; p = 0.07) were not significantly associated with OS. Conclusion: TMT has not appeared as a statistically independent prognostic marker in this cohort of patients with newly diagnosed IDH-wildtype glioblastoma.
Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma
Authors: Liu Junhui , Gao Lun , Zhu Xiaonan , Geng Rongxin , Tao Xiang , Xu Haitao , Chen Zhibiao
Published: November 2021

The gasdermin (GSDM) family act as executioners during pyroptosis. However, its expression and biological role in glioma remain to be determined. This study carried out gene expression from six public datasets. Westerns blots and immunohistochemistry (IHC) staining were employed to examine GSDM expression in glioma in an in-house cohort. Kaplan–Meier and Cox regression analyses were performed to evaluate the prognostic role of GSDMs in glioma. Association between gene expression and immune infiltration was assessed by IHC and immunofluorescence (IF) staining of tissue sections. TMZ-induced pyroptosis was assessed by observation of morphological changes, WB and ELISA detection. Only GSDMD expression was upregulated in glioma compared with nontumor brain tissues both in the public datasets and in-house cohort. High GSDMD expression was significantly associated with WHO grade IV, IDH 1/2 wild-type and mesenchymal subtypes. Besides, high GSDMD expression was associated with shorter overall survival and could be used as an independent risk factor for poor outcomes in LGG and GBM. GO enrichment analysis and IHC validation revealed that GSDMD expression might participate in regulating macrophage infiltration and polarization. TMZ treatment induced the pyroptosis in GBM cells and GSDMD expression increased with after treating with TMZ in a time-dependent manner. Moreover, knocking down GSDMD obviously decreased IL-1β expression and reduced TMZ-induced pyroptosis in in vitro. GSDMD was a novel prognostic biomarker, as well as TMZ-treatment response marker in glioma.
Characterization of Recurrent Relevant Genes Reveals a Novel Role of RPL36A in Radioresistant Oral Squamous Cell Carcinoma
Authors: Chen Ting-Wen , Chang Kai-Ping , Cheng Chun-Chia , Chen Cheng-Yi , Hong Shu-Wen , Sie Zong-Lin , Cheng Hsing-Wen , Yen Wei-Chen , Huang Yenlin , Liu Shu-Chen , Wang Chun-I
Published: November 2021

Radioresistance is one of the major factors that contributes to radiotherapy failure in oral cavity squamous cell carcinoma (OSCC). By comparing the prognostic values of 20,502 genes expressed in patients in The Cancer Genome Atlas (TCGA)-OSCC cohort with (n = 162) and without radiotherapy (n = 118), herein identified 297 genes positively correlated with poor disease-free survival in OSCC patients with radiotherapy as the potential radioresistance-associated genes. Among the potential radioresistance-associated genes, 36 genes were upregulated in cancerous tissues relative to normal tissues. The bioinformatics analysis revealed that 60S ribosomal protein L36a (RPL36A) was the most frequently detected gene involved in radioresistance-associated gene-mediated biological pathways. Then, two independent cohorts (n = 162 and n = 136) were assessed to confirm that higher RPL36A transcript levels were significantly associated with a poor prognosis only in OSCC patients with radiotherapy. Mechanistically, we found that knockdown of RPL36A increased radiosensitivity via sensitizing cells to DNA damage and promoted G2/M cell cycle arrest followed by augmenting the irradiation-induced apoptosis pathway in OSCC cells. Taken together, our study supports the use of large-scale genomic data for identifying specific radioresistance-associated genes and suggests a regulatory role for RPL36A in the development of radioresistance in OSCC.
Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells
Authors: Fritsch Jürgen , Frankenheim Julia , Marischen Lothar , Vadasz Timea , Troeger Anja , Rose-John Stefan , Schmidt-Arras Dirk , Schneider-Brachert Wulf
Published: November 2021

Signaling via death receptor family members such as TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death. Pro-survival signaling is mediated via TNF-R1 complex I at the cellular plasma membrane. Cell death induction requires complex IIa/b or necrosome formation, which occurs in the cytoplasm. In many cell types, full apoptotic or necroptotic cell death induction requires the internalization of TNF-R1 and receptosome formation to properly relay the signal inside the cell. We interrogated the role of the enzyme A disintegrin and metalloprotease 17 (ADAM17)/TACE (TNF-α converting enzyme) in death receptor signaling in human hematopoietic cells, using pharmacological inhibition and genetic ablation. We show that in U937 and Jurkat cells the absence of ADAM17 does not abrogate, but rather increases TNF mediated cell death. Likewise, cell death triggered via DR3 is enhanced in U937 cells lacking ADAM17. We identified ADAM17 as the key molecule that fine-tunes death receptor signaling. A better understanding of cell fate decisions made via the receptors of the TNF-R1 superfamily may enable us, in the future, to more efficiently treat infectious and inflammatory diseases or cancer.
The Combined Effect of ZnO and CeO2 Nanoparticles on Pisum sativum L.: A Photosynthesis and Nutrients Uptake Study
Authors: Skiba Elżbieta , Pietrzak Monika , Glińska Sława , Wolf Wojciech M.
Published: November 2021

Cerium oxide nanoparticles (CeO2 NPs) and zinc oxide nanoparticles (ZnO NPs) are emerging pollutants that are likely to occur in the contemporary environment. So far, their combined effects on terrestrial plants have not been thoroughly investigated. Obviously, this subject is a challenge for modern ecotoxicology. In this study, Pisum sativum L. plants were exposed to either CeO2 NPs or ZnO NPs alone, or mixtures of these nano-oxides (at two concentrations: 100 and 200 mg/L). The plants were cultivated in hydroponic system for twelve days. The combined effect of NPs was proved by 1D ANOVA augmented by Tukey’s post hoc test at p = 0.95. It affected all major plant growth and photosynthesis parameters. Additionally, HR-CS AAS and ICP-OES were used to determine concentrations of Cu, Mn, Fe, Mg, Ca, K, Zn, and Ce in roots and shoots. Treatment of the pea plants with the NPs, either alone or in combination affected the homeostasis of these metals in the plants. CeO2 NPs stimulated the photosynthesis rate, while ZnO NPs prompted stomatal and biochemical limitations. In the mixed ZnO and CeO2 treatments, the latter effects were decreased by CeO2 NPs. These results indicate that free radicals scavenging properties of CeO2 NPs mitigate the toxicity symptoms induced in the plants by ZnO NPs.
Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article
Authors: Bukhari Aysha , Ijaz Irfan , Gilani Ezaz , Nazir Ammara , Zain Hina , Saeed Ramsha , Alarfaji Saleh S. , Hussain Sajjad , Aftab Rizwana , Naseer Yasra
Published: November 2021

Nanotechnology emerged as a scientific innovation in the 21st century. Metallic nanoparticles (metal or metal oxide nanoparticles) have attained remarkable popularity due to their interesting biological, physical, chemical, magnetic, and optical properties. Metal-based nanoparticles can be prepared by utilizing different biological, physical, and chemical methods. The biological method is preferred as it provides a green, simple, facile, ecofriendly, rapid, and cost-effective route for the green synthesis of nanoparticles. Plants have complex phytochemical constituents such as carbohydrates, amino acids, phenolics, flavonoids, terpenoids, and proteins, which can behave as reducing and stabilizing agents. However, the mechanism of green synthesis by using plants is still highly debatable. In this report, we summarized basic principles or mechanisms of green synthesis especially for metal or metal oxide (i.e., ZnO, Au, Ag, and TiO2, Fe, Fe2O3, Cu, CuO, Co) nanoparticles. Finally, we explored the medical applications of plant-based nanoparticles in terms of antibacterial, antifungal, and anticancer activity.
Green Coating Polymers in Meat Preservation
Authors: Gagaoua Mohammed , Bhattacharya Tanima , Lamri Melisa , Oz Fatih , Dib Amira Leila , Oz Emel , Uysal-Unalan Ilke , Tomasevic Igor
Published: November 2021

Edible coatings, including green polymers are used frequently in the food industry to improve and preserve the quality of foods. Green polymers are defined as biodegradable polymers from biomass resources or synthetic routes and microbial origin that are formed by mono- or multilayer structures. They are used to improve the technological properties without compromising the food quality, even with the purpose of inhibiting lipid oxidation or reducing metmyoglobin formation in fresh meat, thereby contributing to the final sensory attributes of the food and meat products. Green polymers can also serve as nutrient-delivery carriers in meat and meat products. This review focuses on various types of bio-based biodegradable polymers and their preparation techniques and applications in meat preservation as a part of active and smart packaging. It also outlines the impact of biodegradable polymer films or coatings reinforced with fillers, either natural or synthesized, via the green route in enhancing the physicochemical, mechanical, antimicrobial, and antioxidant properties for extending shelf-life. The interaction of the package with meat contact surfaces and the advanced polymer composite sensors for meat toxicity detection are further considered and discussed. In addition, this review addresses the research gaps and challenges of the current packaging systems, including coatings where green polymers are used. Coatings from renewable resources are seen as an emerging technology that is worthy of further investigation toward sustainable packaging of food and meat products.
Performance of Automated Point-of-Care Respiratory Rate Counting versus Manual Counting in Children under Five Admitted with Severe Febrile Illness to Kisantu Hospital, DR Congo
Authors: Tack Bieke , Vita Daniel , Mbaki Thomas Nsema , Lunguya Octavie , Toelen Jaan , Jacobs Jan
Published: November 2021

To improve the early recognition of danger signs in children with severe febrile illness in low resource settings, WHO promotes automated respiratory rate (RR) counting, but its performance is unknown in this population. Therefore, we prospectively evaluated the field performance of automated point-of-care plethysmography-based RR counting in hospitalized children with severe febrile illness (<5 years) in DR Congo. A trained research nurse simultaneously counted the RR manually (comparative method) and automatically with the Masimo Rad G pulse oximeter. Valid paired RR measurements were obtained in 202 (83.1%) children, among whom 43.1% (87/202) had fast breathing according to WHO criteria based on manual counting. Automated counting frequently underestimated the RR (median difference of −1 breath/minute; p2.5–p97.5 limits of agreement: −34–6), particularly at higher RR. This resulted in a failure to detect fast breathing in 24.1% (21/87) of fast breathing children (positive percent agreement: 75.9%), which was not explained by clinical characteristics (p > 0.05). Children without fast breathing were mostly correctly classified (negative percent agreement: 98.3%). In conclusion, in the present setting the automated RR counter performed insufficiently to facilitate the early recognition of danger signs in children with severe febrile illness, given wide limits of agreement and a too low positive percent agreement.
In-Place Characterization of On-State Voltage for SiC MOSFETs: Controlled Shoot-Through vs. Film Heater
Authors: Soldati Alessandro , Dalboni Matteo , Menozzi Roberto , Concari Carlo
Published: November 2021

The on-state voltage of MOSFETs is a convenient and powerful temperature-sensitive electric parameter (TSEP) to determine the junction temperature, thus enabling device monitoring, protection, diagnostics and prognostics. The main hurdle in the use of the on-state voltage as a TSEP is the per-device characterization procedure, to be carried out in a controlled environment, with high costs. In this paper, we compare two novel techniques for MOSFET junction temperature estimation: controlled shoot-through and direct heating by resistive heaters embedded in two Kapton (polyimide) films. Both allow in-place characterization of the TSEP curve with the device mounted in its final circuit and assembly, including the working heat sink. The two methods are also validated against the conventional procedure in a thermal chamber.
Modeling and Integrated Optimization of Power Split and Exhaust Thermal Management on Diesel Hybrid Electric Vehicles
Authors: Zhao Jinghua , Hu Yunfeng , Xie Fangxi , Li Xiaoping , Sun Yao , Sun Hongyu , Gong Xun
Published: November 2021

To simultaneously achieve high fuel efficiency and low emissions in a diesel hybrid electric vehicle (DHEV), it is necessary to optimize not only power split but also exhaust thermal management for emission aftertreatment systems. However, how to coordinate the power split and the exhaust thermal management to balance fuel economy improvement and emissions reduction remains a formidable challenge. In this paper, a hierarchical model predictive control (MPC) framework is proposed to coordinate the power split and the exhaust thermal management. The method consists of two parts: a fuel and thermal optimized controller (FTOC) combining the rule-based and the optimization-based methods for power split simultaneously considering fuel consumption and exhaust temperature, and a fuel post-injection thermal controller (FPTC) for exhaust thermal management with a separate fuel injection system added to the exhaust pipe. Additionally, preview information about the road grade is introduced to improve the power split by a fuel and thermal on slope forecast optimized controller (FTSFOC). Simulation results show that the hierarchical method (FTOC + FPTC) can reach the optimal exhaust temperature nearly 40 s earlier, and its total fuel consumption is also reduced by 8.9%, as compared to the sequential method under a world light test cycle (WLTC) driving cycle. Moreover, the total fuel consumption of the FTSFOC is reduced by 5.2%, as compared to the fuel and thermal on sensor-information optimized controller (FTSOC) working with real-time road grade information.
Identification of Novel Mutations by Targeted NGS Panel in Patients with Hyperferritinemia
Authors: Ravasi Giulia , Pelucchi Sara , Bertola Francesca , Capelletti Martina Maria , Mariani Raffaella , Piperno Alberto
Published: November 2021

Background. Several inherited diseases cause hyperferritinemia with or without iron overload. Differential diagnosis is complex and requires an extensive work-up. Currently, a clinical-guided approach to genetic tests is performed based on gene-by-gene sequencing. Although reasonable, this approach is expensive and time-consuming and Next Generation Sequencing (NGS) technology may provide cheaper and quicker large-scale DNA sequencing. Methods. We analysed 36 patients with non-HFE-related hyperferritinemia. Liver iron concentration was measured in 33 by magnetic resonance. A panel of 25 iron related genes was designed using SureDesign software. Custom libraries were generated and then sequenced using Ion Torrent PGM. Results. We identified six novel mutations in SLC40A1, three novel and one known mutation in TFR2, one known mutation and a de-novo deletion in HJV, and a novel mutation in HAMP in ten patients. In silico analyses supported the pathogenic role of the mutations. Conclusions. Our results support the use of an NGS-based panel in selected patients with hyperferritinemia in a tertiary center for iron metabolism disorders. However, 26 out of 36 patients did not show genetic variants that can individually explain hyperferritinemia and/or iron overload suggesting the existence of other genetic defects or gene-gene and gene-environment interactions needing further studies.
Does Emotional Intelligence Increase Satisfaction with Life during COVID-19? The Mediating Role of Depression
Authors: Koçak Orhan
Published: November 2021

COVID-19 has spread rapidly and become a health crisis around the world, and negatively affected the mental state of individuals. Emotional intelligence (EI) can play an important role in coping with the mental problems experienced due to the pandemic. This study examined how individuals’ emotional intelligence levels affect depression and satisfaction with life during the COVID-19 period. The study was designed as quantitative and cross-sectional and reached 578 adult participants online. Emotional intelligence trait scale–short form, depression subscale (DASS-21), satisfaction with life scale, and sociodemographic questions as control variables were used as data collection tools in the study. The data obtained were conducted using SPSS 24, PROCESS-Macro, and Amos 25 statistical programs. The hypotheses established were tested by correlation, multiple regression, mediating, and moderating analyzes. Results confirmed that emotional intelligence had a positive association with satisfaction with life and a negative association with depression. In addition, interaction analyses found that age and family type had a moderating effect on satisfaction with life, and depression had a mediating effect. After discussing the importance of emotional intelligence as a coping mechanism in dealing with problems, some suggestions were made to policymakers and practitioners.
Associations of 24-Hour Movement Behavior with Depressive Symptoms and Anxiety in Children: Cross-Sectional Findings from a Chinese Sample
Authors: Lu Shenghua , Cheval Boris , Yu Qian , Hossain Md Mahbub , Chen Si-Tong , Taylor Alyx , Bao Ran , Doig Scott , Li Jinming , Wang Ting , Yan Zhe , Kuang Jin , Jiao Can , Zou Liye
Published: November 2021

This study examined the associations between adherence to 24-hour movement behavior guidelines (24-HMB) and the mental-health-related outcomes of depressive symptoms and anxiety in Chinese children. Data on movement behavior from 5357 children (4th and 5th grades), including physical activity, recreational screen time and sleep, were self-reported using the Health Behavior School-Aged Children Survey. Depressive symptoms and anxiety were self-reported using the Chinese version of the nine-item Patient Health Questionnaire and the Generalized Anxiety Disorder Scale, respectively. Depressive symptoms and anxiety were treated as categorical variables. Only 3.2% of the participants met physical activity, screen time, and sleep 24-HMB guidelines. Ordinal logistic regressions showed that, compared with participants who met the 24-HMB guidelines, participants who met none (odds ratio (OR) = 2.62, 95% CI: 1.76–3.90) or any one of the guidelines (OR = 1.88, 95% CI: 1.27–2.77) had higher odds of depressive symptoms. Similarly, there were higher odds of anxiety in participants who met none (OR = 2.32, 95% CI: 1.45–3.70) or any one of the recommendations (OR = 1.62, 95% CI: 1.03–2.57) compared with participants who met all the 24-HMB guidelines. Meeting the 24-HMB guidelines is associated with better mental-health-related outcomes in Chinese children. Because of the low prevalence of Chinese children meeting the 24-HMB recommendations, the present findings highlight the need to encourage children to regularly engage in physical activity, decrease their time spent sitting, and improve their sleep patterns.
An Observational Study Comparing Fibromyalgia and Chronic Low Back Pain in Somatosensory Sensitivity, Motor Function and Balance
Authors: Mingorance José Antonio , Montoya Pedro , Miranda José García Vivas , Riquelme Inmaculada
Published: November 2021

Fibromyalgia (FM) and chronic low back pain (CLBP) have shared pathophysiology and have a considerable impact on patients’ daily activities and quality of life. The main objective of this study was to compare pain impact, somatosensory sensitivity, motor functionality, and balance among 60 patients with FM, 60 patients with CLBP, and 60 pain-free controls aged between 30 and 65 years. It is essential to know the possible differences existing in symptomatology of two of the major chronic pain processes that most affect the population, such as FM and CLBP. The fact of establishing possible differences in sensory thresholds, motor function, and proprioceptive measures among patients with FM and CLBP could bring us closer to a greater knowledge of the chronic pain process. Through an observational study, a comparison was made between the three groups (FM, CLBP, and pain-free controls) evaluating functional performance, postural balance, kinematic gait parameters, strength, depression, fatigue, and sensitivity to pain and vibration. Patients with chronic pain showed worse somatosensory sensitivity (p < 0.001) and motor function (p < 0.001) than pain-free controls. Moreover, patients with FM showed greater pain impact (p < 0.001) and bigger somatosensory (p < 0.001) and motor deficiencies (p < 0.001) than patients with CLBP. Further research should explore the possible reasons for the greater deterioration in patients with FM in comparison with other chronic pain conditions. Our results, showing the multiple areas susceptible of deterioration, make it necessary to adopt interdisciplinary interventions focused both on physical and emotional dysfunction.
Correlates of Physical Activity among Adults with Sight Loss in High-Income-Countries: A Systematic Review
Authors: Lindsay Rosie K. , Di Gennaro Francesco , Allen Peter M. , Tully Mark A. , Marotta Claudia , Pizzol Damiano , Gorely Trish , Barnett Yvonne , Smith Lee
Published: November 2021

Background: Physical activity (PA) is essential for almost all facets of health; however, research suggests that PA levels among populations with sight loss are critically low. The aim of this review was to identify the correlates of PA among people with sight loss in high income countries, to inform future interventions and policies. Methods: MEDLINE, Web of Science, PsycINFO, SPORTDiscus, The British Journal of Visual Impairment, The Journal of Visual Impairment and grey literature were searched for studies which reported correlates of PA among adults with sight loss. The protocol is available from PROSPERO (CRD42020215596). Results: A total of 29 articles were eligible for review. Evidence from multiple studies reported that the vision impairment category, worse visual acuity, bilateral visual field loss, worse contrast sensitivity, those of the female gender, low self-efficacy, and environmental barriers were associated with lower levels of PA among populations with sight loss. Conclusions: Overall, correlates of PA among people with sight loss in high income countries are complex and vary across different population groups. Health professionals, eye care, and sight loss services should work together to identify people at risk of low PA, and provide a range of services and interventions to influence the modifiable factors that are associated with low PA.
What Is the Optimal Strength Training Load to Improve Swimming Performance? A Randomized Trial of Male Competitive Swimmers
Authors: Amara Sofiene , Crowley Emmet , Sammoud Senda , Negra Yassine , Hammami Raouf , Chortane Oussema Gaied , Khalifa Riadh , Chortane Sabri Gaied , van den Tillaar Roland
Published: November 2021

This study aimed to compare the effectiveness of high, moderate, and low resistance training volume-load of maximum strength training on muscle strength and swimming performance in competitive swimmers. Thirty-three male swimmers were randomly allocated to high (age = 16.5 ± 0.30 years), moderate (age = 16.1 ± 0.32 years) and a low resistance training volume-load group (age = 15.9 ± 0.31). This study was carried out in mid-season (January to March). Pre and post strength (e.g., repetition maximum [1RM] leg extension and bench press tests), swimming (25, 50 m front-crawl), start (speed, time, distance) and turn (time of turn) performance tests were conducted. Our findings revealed a large main effect of time for 1RM bench press: d = 1.38; 1RM leg extension: d = 1.55, and for 25 (d = 1.12), and 50 m (d = 1.97) front-crawl, similarly for start and turn performance (d = 1.28–1.46). However, no significant Group × Time interactions were shown in all strength swimming performances, start and turn tests (p > 0.05). In conclusion, low training loads have been shown to elicit the same results as moderate, and high training loads protocol. Therefore, this study shows evidence that the addition of low training volume-loads as a regular part of a maximal strength training regime will elicit improvements in strength and swimming performance.
The Influence of Body Position on Determining Aerobic Exercise Intensity for Healthy Individuals
Authors: Peters Rogério de Siqueira , Cruz Maria do Socorro Luna , Hernández-Mosqueira Claudio , Martinez-Salazar Cristian , Barbosa Fernando Policarpo
Published: November 2021

To verify the influence of the resting heart rate (RHR) measurement on different positions in the calculation of VO2max intensities in young individuals of both sexes. Methods: A cross-sectional study with a correlational design with a sample of 22 men and 11 women, aged 27.8 ± 6.5 years and 29.0 ± 8.6 years, respectively, healthy, active and sedentary, who performed the stress test on a treadmill until fatigue. For the treatment of the data, a repeated measures ANOVA was carried out with Bonferroni’s post hoc test. Results: The comparison of the mean values of baseline heart rate (Bhr) between the groups of women and men showed significant differences (t = 2.329; gl 31; p = 0.027). However, no significant differences were noted for lying (t = 0.057; gl 31; p = 0.95), sitting (t = 0.196 gl 31; p = 0.85) or standing (t = −0.290; gl 31; p = 0.77). But in the analysis of the intensities of the RHR in different positions, the calculations with baseline and lying HR were significantly different (p < 0.05). Conclusion: The determination of aerobic training intensities by RHR method must observe the heart rate measurement at rest in the sitting and/or standing positions minutes before the training session.