bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges in Nursing Education in the New Normal: Basis for Faculty Enhancement Program
Authors: Cacayan Edmelyn B. , Baua Ma. Elizabeth C. , Alvarado Angelito Estoesta
Published: September 2020

Education s vital to every Filipino especially the delivery of quality education without compromising the health and safety of the students amidst COVID 19 pandemic. With the current global health crisis and government pronouncements prohibiting the conduct of face-to-face classes both in basic education (DepEd) and Higher education (CHED). Isabela State University has decided to roll out and launched its new approach, called telEducation. It has ramped up its efforts in fully implementing flexible remote learning for its students to ease its transition to what might become the new normal for educational institutions. This study utilized a descriptive survey method of investigation to secure adequate and reliable data. The researcher used this design to gather necessary data, assess and determine the challenges facing nursing education in the new normal by the nursing faculty of Isabela State University, College of Nursing. The questionnaires were floated through the use of google forms as a platform. The respondents who participated in this study were 15 nursing faculty comprises of 7 permanent as core faculty and 8 instructors under a contract of service. This study concluded that inadequate instructor training for new normal education; limited time for the preparation of modules, exams, and other related to instruction is due to the limited time of the university administrators or concern authorities to conduct since the summer class has already implemented. The said interventions made it more difficult to conduct due to the implementing community quarantines. Furthermore, there are numerous nursing-related experiences/activities but limited time for implementation; Students find it difficult to comprehend some activities due to the absence of physical contact of the instructor/s; faculty experiencing physical problems (eg. eye strain and frontal headache) due to long hours of exposure on computer monitor or gadgets are noted concerns in relation to the delivery of instructions.

Keywords: nursing education; new normal; challenges
TEOA Inhibits Proliferation and Induces DNA Damage of Diffuse Large B-Cell Lymphoma Cells Through Activation of the ROS-Dependent p38 MAPK Signaling Pathway
Authors: Yu Xingxing , Wang Xin , Wang Xu , Zhou Yi , Li Yanchun , Wang Aiwei , Wang Tongtong , An Yihan , Sun Weidong , Du Jing , Tong Xiangmin , Wang Ying
Published: September 2020

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of lymphoma, accounting for approximately 30% to 40% of non-Hodgkin’s lymphomas (NHL). The administration of rituximab significantly improved the outcomes of DLBCL; however, the unavoidable development of resistance limits the long-term efficacy. Therefore, a new generation of less toxic drugs with higher chemotherapy response is required to prevent or reverse chemoresistance. TEOA is a pentacyclic triterpenoid compound isolated from the roots of Actinidia eriantha. Studies have confirmed that TEOA has significant cytotoxicity on gastrointestinal cancer cells. However, there are no relevant reports on DLBCL cells. In this study, we investigated the potential molecular mechanism of the anticancer activity of TEOA in DLBCL cells. The results demonstrated that TEOA inhibited proliferation and induced apoptosis in time-and dose-dependent manners. TEOA induced reactive oxygen species (ROS) generation, which was reversed by N-acetyl cysteine (NAC). TEOA induced DNA damage, increased the level of γ-H2AX, and the phosphorylation of CHK1 and CHK2. In addition, TEOA induced the activation of the p38 MAPK pathway and pretreated with p38 inhibitor SB20358 or ROS scavenger could block TEOA-induced DNA damage. Taken together, these results suggest that ROS mediated activation of the p38 MAPK signal pathway plays an important role in initiating TEOA-induced DNA damage.
An Extensive Knowledge Mapping Review of Measurement and Validity in Language Assessment and SLA Research
Authors: Aryadoust Vahid , Zakaria Azrifah , Lim Mei Hui , Chen Chaomei
Published: September 2020

This study set out to investigate intellectual domains as well as the use of measurement and validation methods in language assessment research and second language acquisition (SLA) published in English in peer-reviewed journals. Using Scopus, we created two datasets: (i) a dataset of core journals consisting of 1,561 articles published in four language assessment journals, and (ii) a dataset of general journals consisting of 3,175 articles on language assessment published in the top journals of SLA and applied linguistics. We applied document co-citation analysis to detect thematically distinct research clusters. Next, we coded citing papers in each cluster based on an analytical framework for measurement and validation. We found that the focus of the core journals was more exclusively on reading and listening comprehension assessment (primary), facets of speaking and writing performance such as raters and validation (secondary), as well as feedback, corpus linguistics, and washback (tertiary). By contrast, the primary focus of assessment research in the general journals was on vocabulary, oral proficiency, essay writing, grammar, and reading. The secondary focus was on affective schemata, awareness, memory, language proficiency, explicit vs. implicit language knowledge, language or semantic awareness, and semantic complexity. With the exception of language proficiency, this second area of focus was absent in the core journals. It was further found that the majority of citing publications in the two datasets did not carry out inference-based validation on their instruments before using them. More research is needed to determine what motivates authors to select and investigate a topic, how thoroughly they cite past research, and what internal (within a field) and external (between fields) factors lead to the sustainability of a Research Topic in language assessment.
Development and Long-Term Follow-Up of an Experimental Model of Myocardial Infarction in Rabbits
Authors: Genovés Patricia , Arias-Mutis Óscar J. , Parra Germán , Such-Miquel Luis , Zarzoso Manuel , Del Canto Irene , Soler Carlos , Díaz Ana , Blanch Eva , Alberola Antonio , Such Luis , Chorro Francisco J.
Published: September 2020

A chronic model of acute myocardial infarction was developed to study the mechanisms involved in adverse postinfarction ventricular remodeling. In an acute myocardial infarction (AMI), the left circumflex coronary artery of New Zealand White rabbits (n = 9) was occluded by ligature for 1 h, followed by reperfusion. A specific care protocol was applied before, during, and after the intervention, and the results were compared with those of a sham operated group (n = 7). After 5 weeks, programmed stimulation and high-resolution mapping were performed on isolated and perfused hearts using the Langendorff technique. The infarct size determined by 2,3,5-triphenyltetrazolium chloride inside of the area at risk (thioflavin-S) was then determined. The area at risk was similar in both groups (54.33% (experimental infarct group) vs. 58.59% (sham group), ns). The infarct size was 73.16% as a percentage of the risk area. The experimental infarct group had a higher inducibility of ventricular arrhythmias (100% vs. 43% in the sham group, p = 0.009). A reproducible chronic experimental model of myocardial infarction is presented in which the extent and characteristics of the lesions enable the study of the vulnerability to develop ventricular arrhythmias because of the remodeling process that occurs during cardiac tissue repair.
Differences in Endocrine and Cardiac Changes in Mares and Her Fetus before, during, and after Parturition in Horses of Different Size
Authors: Nagel Christina , Melchert Maria , Aurich Christine , Aurich Jörg
Published: September 2020

Equine fetomaternal monitoring is based on endocrine and cardiac parameters which may differ among small, medium-size, and full-size horses. Therefore, Shetland (n = 6), Haflinger (n = 8), and Warmblood pregnancies (n = 9) were studied during late gestation and at foaling. Weight of mares, foals and placenta, plasma progestin and cortisol concentration, heart rate and heart rate variability (HRV) were determined. Foal weight always approximated 10% of mare weight but relative placenta weight was highest in full-size mares (p < 0.05). Progestin (p < 0.001) and cortisol (p < 0.05) concentration was highest in full-size mares. Progestin concentration decreased towards parturition (p < 0.001) while cortisol concentration increased (p < 0.01). Maternal heart rate increased before foaling with the most pronounced increase in small mares (p < 0.001). The HRV increased during foaling and decreased when delivery was completed (p < 0.001). Changes were most pronounced in full-size mares (p < 0.001). Atrio-ventricular blocks regularly occurred in parturient full-size mares but only occasionally in medium-size and small mares (time p < 0.05, time × group p < 0.05). This may reflect breed differences in cardiovascular efficiency. Fetal heart rate decreased towards birth (p < 0.001) with the most pronounced decrease in full-size horses (p < 0.01). Fetal HRV showed no consistent changes before birth but increased when the foal was born (p < 0.001), this increase being most pronounced in full-size foals (p < 0.05). In conclusion, this study demonstrates both similarities and differences in peripartum endocrine and cardiac changes in horses of different size.
Artemisinin Derivatives Stimulate DR5-Specific TRAIL-Induced Apoptosis by Regulating Wildtype P53
Authors: Zhou Xinyu , Zijlstra Sietske N. , Soto-Gamez Abel , Setroikromo Rita , Quax Wim J.
Published: September 2020

Artemisinin derivatives, widely known as commercial anti-malaria drugs, may also have huge potential in treating cancer cells. It has been reported that artemisinin derivatives can overcome resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in liver and cervical cancer cells. In our study, we demonstrated that artesunate (ATS) and dihydroartemisinin (DHA) are more efficient in killing colon cancer cells compared to artemisinin (ART). ATS/DHA induces the expression of DR5 in a P53 dependent manner in HCT116 and DLD-1 cells. Both ATS and DHA overcome the resistance to DHER-induced apoptosis in HCT116, mainly through upregulating death receptor 5 (DR5). We also demonstrate that DHA sensitizes HCT116 cells to DHER-induced apoptosis via P53 regulated DR5 expression in P53 knockdown assays. Nevertheless, a lower effect was observed in DLD-1 cells, which has a single Ser241Phe mutation in the P53 DNA binding domain. Thus, the status of P53 could be one of the determinants of TRAIL resistance in some cancer cells. Finally, the combination treatment of DHA and the TRAIL variant DHER increases cell death in 3D colon cancer spheroid models, which shows its potential as a novel therapy.
Definition and Independent Validation of a Proteomic-Classifier in Ovarian Cancer
Authors: Kasimir-Bauer Sabine , Roder Joanna , Obermayr Eva , Mahner Sven , Vergote Ignace , Loverix Liselore , Braicu Elena , Sehouli Jalid , Concin Nicole , Kimmig Rainer , Net Lelia , Roder Heinrich , Zeillinger Robert , Aust Stefanie ,   on behalf of the OVCAD (Ovarian Cancer Diagnosis initiative)
Published: September 2020

Mass-spectrometry-based analyses have identified a variety of candidate protein biomarkers that might be crucial for epithelial ovarian cancer (EOC) development and therapy response. Comprehensive validation studies of the biological and clinical implications of proteomics are needed to advance them toward clinical use. Using the Deep MALDI method of mass spectrometry, we developed and independently validated (development cohort: n = 199, validation cohort: n = 135) a blood-based proteomic classifier, stratifying EOC patients into good and poor survival groups. We also determined an age dependency of the prognostic performance of this classifier, and our protein set enrichment analysis showed that the good and poor proteomic phenotypes were associated with, respectively, lower and higher levels of complement activation, inflammatory response, and acute phase reactants. This work highlights that, just like molecular markers of the tumor itself, the systemic condition of a patient (partly reflected in proteomic patterns) also influences survival and therapy response in a subset of ovarian cancer patients and could therefore be integrated into future processes of therapy planning.
Incidences of Deep Molecular Responses and Treatment-Free Remission in de Novo CP-CML Patients
Authors: Etienne Gabriel , Dulucq Stéphanie , Bauduer Fréderic , Adiko Didier , Lifermann François , Dagada Corinne , Lenoir Caroline , Schmitt Anna , Klein Emilie , Madene Samia , Fort Marie-Pierre , Bijou Fontanet , Moldovan Marius , Turcq Beatrice , Robbesyn Fanny , Durrieu Françoise , Versmée Laura , Katsahian Sandrine , Faberes Carole , Lascaux Axelle , Mahon François-Xavier
Published: September 2020

Background: Tyrosine Kinase Inhibitors (TKIs) discontinuation in patients who had achieved a deep molecular response (DMR) offer now the opportunity of prolonged treatment-free remission (TFR). Patients and Methods: Aims of this study were to evaluate the proportion of de novo chronic-phase chronic myeloid leukemia (CP-CML) patients who achieved a sustained DMR and to identify predictive factors of DMR and molecular recurrence-free survival (MRFS) after TKI discontinuation. Results: Over a period of 10 years, 398 CP-CML patients treated with first-line TKIs were included. Median age at diagnosis was 61 years, 291 (73%) and 107 (27%) patients were treated with frontline imatinib (IMA) or second- or third-generation TKIs (2–3G TKI), respectively. With a median follow-up of seven years (range, 0.6 to 13.8 years), 182 (46%) patients achieved a sustained DMR at least 24 months. Gender, BCR-ABL1 transcript type, and Sokal and ELTS risk scores were significantly associated with a higher probability of sustained DMR while TKI first-line (IMA vs. 2–3G TKI) was not. We estimate that 28% of CML-CP would have been an optimal candidate for TKI discontinuation according to recent recommendations. Finally, 95 (24%) patients have entered in a TFR program. MRFS rates at 12 and 48 months were 55.1% (95% CI, 44.3% to 65.9%) and 46.9% (95% CI, 34.9% to 58.9%), respectively. In multivariate analyses, first-line 2–3G TKIs compared to IMA and TKI duration were the most significant factors of MRFS. Conclusions: Our results suggest that frontline TKIs have a significant impact on TFR in patients who fulfill the selection criteria for TKI discontinuation.
Muscle Homeostasis and Regeneration: From Molecular Mechanisms to Therapeutic Opportunities
Authors: Musarò Antonio
Published: September 2020

The capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program and involves the activation of the muscle compartment of stem cells, namely satellite cells, as well as other precursor cells, whose activity is strictly dependent on environmental signals. However, muscle regeneration is severely compromised in several pathological conditions due to either the progressive loss of stem cell populations or to missing signals that limit the damaged tissues from efficiently activating a regenerative program. It is, therefore, plausible that the loss of control over these cells’ fate might lead to pathological cell differentiation, limiting the ability of a pathological muscle to sustain an efficient regenerative process. This Special Issue aims to bring together a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration and to suggest potential therapeutic approaches for degenerating muscle disease.
Al2O3 + Graphene Low-Friction Composite Coatings Prepared By Sol–Gel Method
Authors: Pietrzyk Bożena , Miszczak Sebastian , Sun Ye , Szymański Marcin
Published: September 2020

In this work, Al2O3 + graphene coatings were prepared using the sol–gel method. The aim of the study was preliminary determination of the influence of size and amount of graphene nanoplatelets on morphology, chemical structure, and basic tribological properties of Al2O3 + graphene composite coatings. Two types of reduced graphene oxide (rGO) nanoplatelets with different lateral size and thickness were used to prepare the coatings. To characterize them, scanning electron microscope (SEM), glow discharged optical emission spectrometer (GDOES), Fourier-transform infrared (FTIR), reflectance spectrometer, and ball-on-disk tribological tests were used. It was found that the presence of graphene in the Al2O3 + graphene coatings did not fundamentally change the chemical transformation of ceramic Al2O3 matrix. Morphology examinations of coatings containing larger graphene nanoplatelets revealed a tendency to their parallel arrangement in relation to the coated surface. The tribological properties of Al2O3 + graphene coatings turned out to be strongly dependent on the size of graphene nanoplatelets as well as on the heat treatment temperature. The friction coefficient as low as 0.11 and good durability were obtained for the Al2O3 + graphene coating with larger nanoplatelets and heat-treated at 500 °C. The results of conducted research indicate the potential use of Al2O3 + graphene composite coatings prepared by the sol–gel method as low-friction ceramic coatings.
Spectral Properties of Photo-Aligned Photonic Crystal Fibers Infiltrated with Gold Nanoparticle-Doped Ferroelectric Liquid Crystals
Authors: Budaszewski Daniel , Wolińska Kaja , Jankiewicz Bartłomiej , Bartosewicz Bartosz , Woliński Tomasz Ryszard
Published: September 2020

This paper describes our recent results on light propagation in photonic crystal fibers (PCFs) partially infiltrated with W212 ferroelectric liquid crystal (FLC) doped with 1–3 nm gold nanoparticles (NPs) with a concentration in the range of 0.1–0.5% wt. Based on our previous results devoted to PCFs infiltrated with nematic liquid crystals (NLCs) doped with gold NPs (GNPs), we extend our research line with FLCs doped with these NPs. To enhance the proper alignment of the NP-FLC nanocomposites inside PCFs, we applied an additional photo-aligning layer of SD-1 azo-dye material (DIC, Japan). Electro-optical response times and thermal tuning were studied in detail. We observed an improvement in response times for NP-FLC nanocomposites in comparison to the undoped FLC.
DC Bus Voltage Control of Grid-Side Converter in Permanent Magnet Synchronous Generator Based on Improved Second-Order Linear Active Disturbance Rejection Control
Authors: Zhou Xuesong , Zhou Yongliang , Ma Youjie , Yang Luyong , Yang Xia , Zhang Bo
Published: September 2020

In the permanent magnet synchronous generator (PMSG), the DC bus voltage fluctuates up and down under the influence of the load and power grid, which greatly affects the safe and reliable work of PMSG. In order to suppress the wide range fluctuation of DC bus voltage under disturbance and enhance its anti-disturbance performance, an optimized DC bus voltage control strategy is proposed by using the improved linear active disturbance rejection control (LADRC) in the voltage outer loop. By considering factors, such as load disturbance and grid voltage mutation as the total disturbance of the system, the improved reduced-order linear expansion state observer (RLSEO) is used to estimate and compensate the total disturbance, which greatly improves the stability of DC bus voltage. Firstly, the mathematical model of grid-side converter is established. On this basis, the LADRC control based on RLESO is designed, which reduces the phase lag of the linear extended state observer (LESO) and enhances the disturbance observation accuracy of the system. Then, a lead lag correction link is added to the total disturbance channel of RLESO to reduce the noise amplification effect of RLESO. Finally, the frequency domain characteristic analysis and stability proof of the improved LADRC control strategy are carried out. The simulation results show that the control strategy proposed in the article has a better control effect on the DC bus voltage.
Defrosting Performance Improvement of Air-Source Heat Pump Combined Refrigerant Direct-Condensation Radiant Floor Heating System with Phase Change Material
Authors: Zheng Chenxiao , You Shijun , Zhang Huan , Liu Zeqin , Zheng Wandong , Wu Zhenjing , Fan Man
Published: September 2020

Traditional defrosting methods applied to solve frosting problems of air-source heat pumps operating in cold periods may reduce heat capacity of the system and decrease indoor thermal comfort. In order to improve the performance of air-source heat pump (ASHP) and maintain indoor temperature in defrosting conditions, an air-source heat pump combined with a refrigerant direct-condensation radiant floor heating system with phase change material is proposed and evaluated in this study. Two radiant floor heating terminals with and without composite phase change material modules were compared through experiments. A composite phase change material based on dodecanoic acid-tetradecanol-hexadecanol mixture and expanded graphite was investigated for this application. Experimental results indicate that both heat fluxes of two comparing terminals are higher than 70 W/m2 in heating condition. At the same time, the floor surface temperature, indoor air temperature, and heating capacity of the terminal with composite phase change material modules are higher than those without composite phase change material modules in defrosting condition. This suggests that the proposed system with composite phase change material modules can improve indoor thermal comfort in defrosting condition as well as satisfy the heating requirement in heating condition.
Energy Inputs in Motor-Manual Release Cutting of Broadleaved Forests: Results of Twelve Options
Authors: Boja Nicuşor , Borz Stelian Alexandru
Published: September 2020

Lignocellulosic biomass is used in various industries and its procurement involves a set of operations that are mainly done using equipment powered by internal combustion engines. The sustainability of forest operations may be characterized by balancing their energy inputs with those typically embodied in their outputted products. Forest tending operations are problematic because most of them cannot output marketable products while the data on their energy inputs are important for the forest management. Six of the most commonly used brushcutters equipped successively with discs and knives were tested to provide part of the data needed to run an energy analysis and to be able to characterize the energy inputs in release cutting operations by implementing the Gross Energy Requirements method. Fuel burning was found to have the greatest contribution (83–92%) in the total energy inputs (0.8–1.2 GJ/ha) of the studied operations and it was highly dependent on the efficiency of operations. Moreover, by simulation, it was identified that factors such as the assumed service life of equipment may significantly affect the outcomes of the analysis. Release cutting operations may be seen as important contributors in the energy balance of forest operations and data provided by this study may be of help for both forest management and more detailed and scaled analyses such as that of the Life Cycle Assessment.
4H-SiC Double-Trench MOSFET with Side Wall Heterojunction Diode for Enhanced Reverse Recovery Performance
Authors: Kim Junghun , Kim Kwangsoo
Published: September 2020

In this study, a novel 4H-SiC double-trench metal-oxide semiconductor field-effect transistor (MOSFET) with a side wall heterojunction diode is proposed and investigated by conducting numerical technology computer-aided design simulations. The junction between P+ polysilicon and the N-drift layer forming a heterojunction diode on the side wall of the source trench region suppresses the operation of the PiN body diode during the reverse conduction state. Therefore, the injected minority carriers are completely suppressed, reducing the reverse recovery current by 73%, compared to the PiN body diodes. The switching characteristics of the proposed MOSFET using the heterojunction diode as a freewheeling diode was compared to the power module with a conventional MOSFET and an external diode as a freewheeling diode. It is shown that the switching performance of the proposed structure exhibits equivalent characteristics compared to the power module, enabling the elimination of an external freewheeling diode in the power system.
Energy, Environmental, and Economic Analyses of Geothermal Polygeneration System Using Dynamic Simulations
Authors: Ceglia Francesca , Macaluso Adriano , Marrasso Elisa , Roselli Carlo , Vanoli Laura
Published: September 2020

This paper presents a thermodynamic, economic, and environmental analysis of a renewable polygeneration system connected to a district heating and cooling network. The system, fed by geothermal energy, provides thermal energy for heating and cooling, and domestic hot water for a residential district located in the metropolitan city of Naples (South of Italy). The produced electricity is partly used for auxiliaries of the thermal district and partly sold to the power grid. A calibration control strategy was implemented by considering manufacturer data matching the appropriate operating temperature levels in each component. The cooling and thermal demands of the connected users were calculated using suitable building dynamic simulation models. An energy network dedicated to heating and cooling loads was designed and simulated by considering the variable ground temperature throughout the year, as well as the accurate heat transfer coefficients and pressure losses of the network pipes. The results were based on a 1-year dynamic simulation and were analyzed on a daily, monthly, and yearly basis. The performance was evaluated by means of the main economic and environmental aspects. Two parametric analyses were performed by varying geothermal well depth, to consider the uncertainty in the geofluid temperature as a function of the depth, and by varying the time of operation of the district heating and cooling network. Additionally, the economic analysis was performed by considering two different scenarios with and without feed-in tariffs. Based on the assumptions made, the system is economically feasible only if feed-in tariffs are considered: the minimum Simple Pay Back period is 7.00 years, corresponding to a Discounted Pay Back period of 8.84 years, and the maximum Net Present Value is 6.11 M€, corresponding to a Profit Index of 77.9% and a maximum Internal Rate of Return of 13.0%. The system allows avoiding exploitation of 27.2 GWh of primary energy yearly, corresponding to 5.49∙103 tons of CO2 avoided emissions. The increase of the time of the operation increases the economic profitability.
Designing, Prototyping, Assembling and Costs Analysis of a Gas Turbine Hybrid Vehicle
Authors: Capata Roberto , Tatti Francesco
Published: September 2020

Hybrid vehicles currently represent a compromise between the maturity of conventional vehicles and the low consumption and attention to environmental issues of electric vehicles. This article analyzes the feasibility of a hybrid series vehicle where the heat engine is replaced by a micro gas turbine. In the continuous generation of electric current, it has numerous advantages compared to an internal combustion engine and the purpose of the article is to verify whether these advantages also apply to traction in a hybrid vehicle. The model will be a city car as problems in urban environments of pollution and optimization of consumption are more revealing. After defining performance requirements, the main components are sized and then selected from the catalog, paying attention in the search for a compromise between performance, space constraints, and costs. The Advisor software will then be used to simulate the configuration in both urban and suburban cycles, paying attention to performance, the state of charge of the battery, the operating points of the microturbine, the input and output energy for each element, and fuel consumption. Then, we analyze the level of pollutant emissions to verify that they are lower than the values set by European legislation, specifically the EURO 6 standard. Finally, the total life cycle costs of the car are analyzed as the sum of the purchase cost, operating costs, and maintenance costs to verify the competitiveness of the configuration in the current market. The car was then compared with the Toyota Yaris Hybrid in terms of performance, fuel consumption, emissions, and costs to highlight advantages and disadvantages.
A New Approach to Optimal Location and Sizing of DSTATCOM in Radial Distribution Networks Using Bio-Inspired Cuckoo Search Algorithm
Authors: Kaliaperumal Rukmani Devabalaji , Thangaraj Yuvaraj , Subramaniam Umashankar , Ramachandran Sitharthan , Madurai Elavarasan Rajvikram , Das Narottam , Baringo Luis , Imran Abdul Rasheed Mohamed
Published: September 2020

This article proposes a new approach based on a bio-inspired Cuckoo Search Algorithm (CSA) that can significantly envisage with several issues for optimal allocation of distribution static compensator (DSTATCOM) in Radial Distribution System (RDS). In the proposed method, optimal locations of the DSTATCOM are calculated by using the Loss Sensitivity Factor (LSF). The optimal size of the DSTATCOM is simulated by using the newly developed CSA. In the proposed method, load flow calculations are performed by using a fast and efficient backward/forward sweep algorithm. Here, the mathematically formed objective function of the proposed method is to reduce the total system power losses. Standard 33-bus and 69-bus systems have been used to show the effectiveness of the proposed CSA-based optimization method in the RDS with different load models. The simulated results confirm that the optimal allocation of DSTATCOM plays a significant role in power loss minimization and enhanced voltage profile. The placement of DSTATCOM in RDS also plan an important role for minimizing uncertainties in the distribution level. The proposed method encourages one to use renewable-based resources, which results in affordable and clean energy.
Are Secondary Forests Ready for Climate Change? It Depends on Magnitude of Climate Change, Landscape Diversity and Ecosystem Legacies
Authors: Frelich Lee E. , Jõgiste Kalev , Stanturf John , Jansons Aris , Vodde Floortje
Published: September 2020

In this review and synthesis paper, we review the resilience of secondary forests to climate change through the lenses of ecosystem legacies and landscape diversity. Ecosystem legacy of secondary forests was categorized as continuous forest, non-continuous forest, reassembled after conversion to other land uses, and novel reassembled forests of non-native species. Landscape diversity, including landforms that create varied local climatic and soil conditions, can buffer changing climate to some extent by allowing species from warmer climates to exist on warm microsites, while also providing refugial locations for species that grow in cool climates. We present five frames that allow forest managers to visualize a trajectory of change in the context of projected regional climate change, which are: Frame 1 (persistence), keep the same dominant tree species with little change; Frame 2 (moderate change), keep the same tree species with large changes in relative abundance; Frame 3 (forest biome change), major turnover in dominant tree species to a different forest biome; Frame 4 (forest loss), change from a forest to a non-forest biome; and Frame 5 (planted novel ecosystem), establish a novel ecosystem to maintain forest. These frames interact with ecosystem legacies and landscape diversity to determine levels of ecosystem resilience in a changing climate. Although forest readiness to adapt to Frame 1 and 2 scenarios, which would occur with reduced greenhouse gas emissions, is high, a business as usual climate change scenario would likely overwhelm the capacity of ecosystem legacies to buffer forest response, so that many forests would change to warmer forest biomes or non-forested biomes. Furthermore, the interactions among frames, legacies, and landscape diversity influence the transient dynamics of forest change; only Frame 1 leads to stable endpoints, while the other frames would have transient dynamics of change for the remainder of the 21st century.
Bioconversion of Fish Discards through the Production of Lactic Acid Bacteria and Metabolites: Sustainable Application of Fish Peptones in Nutritive Fermentation Media
Authors: Vázquez José Antonio , Durán Ana I. , Menduíña Araceli , Nogueira Margarita , Gomes Ana María , Antunes Joana , Freitas Ana Cristina , Dagá Esther , Dagá Paula , Valcarcel Jesus
Published: September 2020

In the current work, we study the capacity of 30 peptones obtained by enzyme proteolysis of ten discarded fish species (hake, megrim, red scorpionfish, pouting, mackerel, gurnard, blue whiting, Atlantic horse mackerel, grenadier, and boarfish) to support the growth and metabolite production of four lactic acid bacteria (LAB) of probiotic and technological importance. Batch fermentations of Lactobacillus plantarum, L. brevis, L. casei, and Leuconostoc mesenteroides in most of the media formulated with fish peptones (87% of the cases) led to similar growths (quantified as dry-weight biomass and viable cells) and metabolites (mainly lactic acid) than in commercial control broth (MRS). Comparisons among cultures were performed by means of the parameters obtained from the mathematical fittings of experimental kinetics to the logistic equation. Modelling among experimental and predicted data from each bioproduction was generally accurate. A simple economic assessment demonstrated the profitability achieved when MRS is substituted by media formulated with fish discards: a 3–4-fold reduction of costs for LAB biomass, viable cells formation, and lactic and acetic acid production. Thus, these fish peptones are promising alternatives to the expensive commercial peptones as well as a possible solution to valorize discarded fish biomasses and by-products.
Developing Nursing Standard Guidelines for Nurses in a Neonatal Intensive Care Unit: A Delphi Study
Authors: Lee Hanna , Kim Da-Jung , Han Jeong-Won
Published: September 2020

The purpose of this study is to develop nursing standard guidelines for nurses in a neonatal intensive care unit. The Delphi method was used in this study to elicit expert consensus. Thirteen experts who were nurses and pediatric adolescent specialists working in the neonatal intensive care unit participated in the study. In this study, 178 items were developed based on 5 nursing practice standards and 7 standards of professional practice. An additional 10 items were included based on observation in the neonatal intensive care unit. After expert validation, a final total of 184 items was developed. The standard guidelines for high-risk neonatal care developed in this study for practical clinical education in nursing are significant because they reflect the nursing practice standards in Korea and characteristics of nursing practice in the neonatal intensive unit.
Trichoderma spp. and Mulching Films Differentially Boost Qualitative and Quantitative Aspects of Greenhouse Lettuce under Diverse N Conditions
Authors: Di Mola Ida , Ottaiano Lucia , Cozzolino Eugenio , Senatore Mauro , Sacco Adriana , El-Nakhel Christophe , Rouphael Youssef , Mori Mauro
Published: September 2020

The global increasing demand of lettuce is pushing farmers to boost their production through several technical means, including mulching and nitrogen fertilization. However, from an environmental protection perspective, the role of scientific research is to limit the excessive use of some chemical approaches. This research aims to evaluate the possible effects of two mulching films (black polyethylene, PE, and brown photoselective film, BF) and two treatments with a plant growth-promoting product, containing Trichoderma spp., (non-treated, - Control and treated with RYZO PEP UP, - TR), on the productive and qualitative traits of lettuce grown under four regimes of nitrogen (0, 30, 60 and 90 kg ha−1, N0, N30, N60, and N90, respectively). The marketable yield increased at higher nitrogen levels, but without differences between the N60 and N90 doses. The photoselective film elicited marketable yield, with an 8% increase over PE. N fertilization also improved photochemical efficiency (higher Soil Plant Analysis Development and chlorophyllous pigments biosynthesis), as well as antioxidant activities (lipophilic—LAA and hydrophilic—HAA) and bioactive compounds (phenols and total ascorbic acid—TAA). Interestingly, Trichoderma spp. had a positive effect on these qualitative parameters, especially when combined with mulching films, where the increase generated by PE-TR treatment over the all other treatments was 16.3% and 16.8% for LAA and HHA, respectively. In all treatments, the nitrate leaves content was consistently always within the legal limit imposed by the European community. Overall, although Trichoderma spp. did not engender a marked effect on yield, probably due to the short crop cycle, its positive effect on some quality traits is an interesting starting point for further research.
Psychological Well-Being of Female-Headed Households Based on Age Stratification: A Nationwide Cross-Sectional Study in South Korea
Authors: Kwon Min , Kim HyungSeon
Published: September 2020

The female-headed household is a new vulnerable group associated with health inequality. The purpose of this study was to analyze psychological well-being and related factors among Korean female-headed households based on age stratification. This was a secondary analysis of data extracted from the fifth Korean Working Conditions Survey (2017), which included a total of 9084 female-headed households. Their psychological well-being was measured by the WHO-5 well-being index. A total of 39.8% of female-headed household workers were psychologically unhealthy. Among them, 2.2% of those aged 15–30 years old, 8.1% aged 30–50 years old, and 29.5% over aged 50 years old were unhealthy. In the age group of 15–30 years old, depression/anxiety was negatively associated with psychological well-being. In the age group of 30–50 years old, living alone, musculoskeletal pain, fatigue, and depression/anxiety were negatively associated with psychological well-being. In the age group over 50 years old, low education level, living alone, low income, musculoskeletal pain, fatigue, and depression/anxiety were negatively associated with psychological well-being. The psychological well-being perceived by female households is complex and goes beyond economic poverty and dependent burdens. Therefore, a multidimensional support strategy should be included in the concept of social deprivation, and a preventive approach is needed to establish a support system.
Statistical Analysis of Safety Performance of Displaced Left-Turn Intersections: Case Studies in San Marcos, Texas
Authors: Qu Wenrui , Sun Qiao , Zhao Qun , Tao Tao , Qi Yi
Published: September 2020

Displaced left-turn (DLT) intersections are designed to increase the mobility of vehicles by relocating the left-turn lane (lanes) to the far-left side of the road upstream of the main signalized intersection. Since DLT is a relatively new design and very limited crash data are available, previous studies have focused mainly on the analysis of its operational performance rather than its safety performance. To fill this gap, in this study, we investigated the safety performance of two DLT intersections located in San Marcos, Texas. Crash data from 2011 to April 2018 were extracted from the TxDOT Crash Record Information System (CRIS). These crash data were analyzed using two different approaches, i.e., statistical analysis and collision diagram-based analysis. The results of this study indicated that DLT did not increase the overall crash frequencies at the studied intersections. Traffic crashes related to left turns and right turns were reduced significantly by DLT. Meanwhile, it also caused safety issues related to traffic signage, traffic signal, geometric design, and access management at DLT intersections. Thus, in the implementation of DLT intersections, traffic engineers need to carefully consider different aspects of the DLT intersection design, including access management, traffic signal coordination, and driver acceptance. As a result of these analyses, recommendations were provided for the safe implementation of the DLT design in the future.
Risk of Excess and Inadequate Gestational Weight Gain among Hispanic Women: Effects of Immigration Generational Status
Authors: Daundasekara Sajeevika S. , O’Connor Daniel P. , Berger Cardoso Jodi , Ledoux Tracey , Hernandez Daphne C.
Published: September 2020

There is a dearth of information on the risk of inadequate and excess gestational weight gain (GWG) among different generations of Hispanic women in the United States. Therefore, the objective of this study was to understand the relationship of GWG and immigration across three generations of Hispanic women. The study was conducted using data from National Longitudinal Survey of Youth 1979 (NLSY79). The study sample included 580 (unweighted count) women (148 first-generation, 117 second-generation, and 315 third-/higher-generation). Sociodemographic and immigration data were extracted from the main NLSY79 survey, and pregnancy data were extracted from the child/young adult survey following the biological children born to women in NLSY79. Covariate adjusted weighted logistic regression models were conducted to assess the risk of inadequate and excess GWG among the groups. Average total GWG was 14.98 kg, 23% had inadequate GWG, and 50% had excess GWG. After controlling for the covariates, there was no difference in the risk of inadequate GWG between the three generations. First-generation women (OR = 0.47, p = 0.039) and third-/higher-generation women (OR = 0.39, p = 0.004) had significantly lower risk of excess GWG compared to second-generation women. It is important to recognize the generational status of Hispanic women as a risk factor for excess GWG.
Nurses’ Perspectives on Health Education and Health Literacy of Older Patients
Authors: Kim Min Young , Oh Seieun
Published: September 2020

In the context of population aging, enhancing the health of older patients has become an urgent issue for public health. Health education and health literacy need to be further understood from the healthcare providers’ standpoint to increase older patients’ effective application of such information into their daily lives. We aimed to further understand nurses’ perspectives on the education of older patients and their health literacy, as nurses are one of the frontline providers interacting with older patients. In total, 16 nurses and nurse practitioners who had 5 or more years of clinical experience participated. Data were collected via face-to-face interviews and emails. Data analysis followed the thematic analysis suggested by Braun and Clarke. Five themes emerged from the analysis, as follows: attitudes that are hard to change; physical and cognitive functional barriers to understanding teaching materials; family caregivers—surrogate vs. gatekeeper; major contexts that moderate the elderly’s health literacy; and strategies to enhance teaching effectiveness and health literacy. These findings illustrate the conditions pertinent to communication with older adults from the patients’, providers’ and healthcare delivery viewpoints. Systemic assistance and interventions specialized for older patients and their healthcare providers need to be developed and tested to improve clinical practice and patient health literacy.
Interleukin-36 Cytokine/Receptor Signaling: A New Target for Tissue Fibrosis
Authors: Melton Elaina , Qiu Hongyu
Published: September 2020

Tissue fibrosis is a major unresolved medical problem, which impairs the function of various systems. The molecular mechanisms involved are poorly understood, which hinders the development of effective therapeutic strategies. Emerging evidence from recent studies indicates that interleukin 36 (IL-36) and the corresponding receptor (IL-36R), a newly-characterized cytokine/receptor signaling complex involved in immune-inflammation, play an important role in the pathogenesis of fibrosis in multiple tissues. This review focuses on recent experimental findings, which implicate IL-36R and its associated cytokines in different forms of organ fibrosis. Specifically, it outlines the molecular basis and biological function of IL-36R in normal cells and sums up the pathological role in the development of fibrosis in the lung, kidney, heart, intestine, and pancreas. We also summarize the new progress in the IL-36/IL-36R-related mechanisms involved in tissue fibrosis and enclose the potential of IL-36R inhibition as a therapeutic strategy to combat pro-fibrotic pathologies. Given its high association with disease, gaining new insight into the immuno-mechanisms that contribute to tissue fibrosis could have a significant impact on human health.
Role of miR-30a-3p Regulation of Oncogenic Targets in Pancreatic Ductal Adenocarcinoma Pathogenesis
Authors: Shimomura Hiroki , Okada Reona , Tanaka Takako , Hozaka Yuto , Wada Masumi , Moriya Shogo , Idichi Tetsuya , Kita Yoshiaki , Kurahara Hiroshi , Ohtsuka Takao , Seki Naohiko
Published: September 2020

Our recent studies have implicated some passenger strands of miRNAs in the molecular pathogenesis of human cancers. Analysis of the microRNA (miRNA) expression signature in pancreatic ductal adenocarcinoma (PDAC) has shown that levels of miR-30a-3p, the passenger strand derived from pre-mir-30a, are significantly downregulated in PDAC tissues. This study aimed to identify the oncogenes closely involved in PDAC molecular pathogenesis under the regulation of miR-30a-3p. Ectopic expression assays showed that miR-30a-3p expression inhibited the aggressiveness of the PDAC cells, suggesting that miR-30a-3p acts as a tumor-suppressive miRNA in PDAC cells. We further identified 102 putative targets of miR-30a-3p regulation in PDAC cells by combining in silico analysis with gene expression data. Of these, ten genes (EPS8, HMGA2, ENDOD1, SLC39A10, TGM2, MGLL, SERPINE1, ITGA2, DTL, and UACA) were independent prognostic factors in multivariate analysis of survival of patients with PDAC (p < 0.01). We also investigated the oncogenic function of the integrin ITGA2 in PDAC cell lines. The integrin family comprises cell adhesion molecules expressed as heterodimeric, transmembrane proteins on the surface of various cells. Overexpression of ITGA2/ITGB1 (an ITGA2 binding partner) was detected in the PDAC clinical specimens. The knockdown of ITGA2 expression attenuated the malignant phenotypes of the PDAC cells. Together, results from these microRNA-based approaches can accelerate our understanding of PDAC molecular pathogenesis.