bluuebunny/crossref_metadata_2025 huggingface dataset:
Ion-induced assemblies of highly anisotropic nanoparticles are governed by ion–ion correlation and specific ion effects
Authors: Benselfelt Tobias , Nordenström Malin , Hamedi Mahiar Max , Wågberg Lars
Published: February 2019

Ion-induced assemblies of highly anisotropic nanoparticles can be explained by a model consisting of ion–ion correlation and specific ion effects: dispersion interactions, metal–ligand complexes, and local acidic environments.
Effect of alternan versus chitosan on the biological properties of human mesenchymal stem cells
Authors: Charoenwongpaiboon Thanapon , Supraditaporn Kantpitchar , Klaimon Phatchanat , Wangpaiboon Karan , Pichyangkura Rath , Issaragrisil Surapol , Lorthongpanich Chanchao
Published: February 2019

Alternan α-1,3- and α-1,6-linked glucan, promotes proliferation, migration, and differentiation of human MSCs.
Bimetallic nickel-lutetium complexes: tuning the properties and catalytic hydrogenation activity of the Ni site by varying the Lu coordination environment
Authors: Ramirez Bianca L. , Sharma Prachi , Eisenhart Reed J. , Gagliardi Laura , Lu Connie C.
Published: February 2019

Varying the Lu coordination environment tunes the Ni–Lu interaction and the catalytic activity of the Ni site in styrene hydrogenation.
Correction: Solution-processed wrinkled electrodes enable the development of stretchable electrochemical biosensors
Authors: Chan Yuting , Skreta Marta , McPhee Hannah , Saha Sudip , Deus Ryan , Soleymani Leyla
Published: February 2019

Correction for ‘Solution-processed wrinkled electrodes enable the development of stretchable electrochemical biosensors’ by Yuting Chan et al., Analyst, 2019, 144, 172–179.
Monolayer tellurenyne assembled with helical telluryne: structure and transport properties
Authors: Qi Liujian , Han Jie , Gao Wang , Jiang Qing
Published: February 2019

Tunable carrier mobility, giant Rashba effect, and remarkable stability make noncovalent bond tellurenyne promising for applications in electronics and spintronics.
Polyaddition of vinyl ethers and phthalaldehydes via successive cyclotrimerization reactions: selective model reactions and synthesis of acid-degradable linear poly(cyclic acetal)s
Authors: Naito Tadashi , Kanazawa Arihiro , Aoshima Sadahito
Published: February 2019

A polyaddition via the cyclotrimerization of one vinyl monomer and two conjugated dialdehydes proceeded using a Lewis acid catalyst, yielding a polymer with cyclic acetal structures in the main chain.
The relationship between Fas and Fas ligand gene polymorphism and preeclampsia risk
Authors: Wang Tingting , Lian Yunyun
Published: February 2019

Preeclampsia is an idiopathic multisystem disorder with partial genetic and immunological etiology. Several studies investigated the association between various single-nucleotide polymorphisms (SNPs) in Fas and Fas ligand (FasL) genes and the risk of preeclampsia. However, they achieved inconsistent results. Therefore, we conducted a meta-analysis by systematically searching the Cochrane Library, PubMed and Embase databases and assessed this association by calculating pooled odds ratios with 95% confidence interval to reach a more trustworthy conclusion. Subgroup analyses by genotype methods and source of controls (SOC) were also conducted. Seven citations containing nine studies were included for four SNPs (Fas -670 A/G, FasL 124A/G, FasL -844C/T, Fas -1377 G/A) in this meta-analysis. Our data suggested the G allele and genotype GG of the Fas -670 A/G polymorphism, GG genotype of the FasL 124A/G polymorphism, and TT genotype of the FasL -844C/T polymorphism increased the risk of preeclampsia. Stratification analyses by genotype methods and SOC also indicated that Fas -670 A/G polymorphism was related to increased risk for preeclampsia. In conclusion, Fas and FasL gene polymorphisms play important roles in the development of preeclampsia. Further well-designed studies in other races are needed to confirm the findings of this meta-analysis.
Inhibition of PAK1 alleviates cerulein-induced acute pancreatitis via p38 and NF-κB pathways
Authors: Zhu Minghui , Xu Yan , Zhang Wenbin , Gu Tianyi , Wang Daming
Published: February 2019

Acute pancreatitis is a life-threatening disease accompanied by systemic inflammatory response. NF-κB and p38 signal pathways are activated in AP induced by cerulein. And PAKs are multifunctional effectors of Rho GTPases with kinase activity. In the present study, the function of P21-activated kinase 1 (PAK1) in AP was investigated, and found that PAK1 was up-regulated in pancreas of AP mice model, and led to NF-κB and p38 pathway activation. PAK1 inhibition by shRNA or small molecule inhibitor FRAX597 decreased NF-κB and p38 activity, also alleviated the pathological damage in the pancreas of AP mice model, including decreasing the amylase and lipase levels in serum, decreasing the levels of tumor necrosis factor-α, interleukin-6, and interleukin-1β in AP. These results suggested that PAK1 inhibition protects against AP by inhibiting NF-κB and p38 pathways, and indicated that PAK1 is a potential therapy to alleviate AP patients in clinic, and these need to be explored further.
Pennsylvania Speech-Language-Hearing Association
Authors: Coleman Craig
Published: February 2019

Q & A with Craig Coleman, president of the PSHA
Magnetic nanoparticles preparation by chemical reduction for biomedical applications
Authors: Kelgenbaeva Zhazgul , Murzubraimov Bektemir , Kozlovsky Artem , Adil Akai Tegin Ruslan , Turdubai kyzy Ainur , Murzabekova Elmira , Aidaraliev Janbolot , Dyusheeva Begimzhan
Published: February 2019

This work presents Fe3O4 and AgFe nanoparticles with an average diameter of 25 and 15 nm synthesized by chemical reduction of corresponding salts under a mild condition. Cubic crystal structure and spherical shape of the nanoparticles were studied by X-ray diffraction, Field emission SEM and energy-dispersive spectroscopy analysis. For biomedical applications, the nanoparticles were tested against bacteria E.coli and results revealed AgFe nanoparticles’ antibacterial activity by forming lysis zone in scale of 0.5 mm.
A combined DFT/topological analysis approach for modeling disordered solid electrolytes
Authors: Zolotarev Pavel , Nekrasova Nadezhda , Golov Andrey , Eremin Roman
Published: February 2019

In the scope of this study, the Ag2S·CdS·3SnS2 solid electrolyte disordered in the Cd/Sn sublattice is explored by means of the approach involving configurational space (CS) setting and first-principles calculations. Within the density functional theory calculations on the CS, the absolute differences in Ag vacancy formation energies up to 2.6 eV/cell were obtained for possible Cd/Sn dispositions. Subsequently, silver ion migration was modeled using the nudged elastic band method. The migration energies in the range of 0.250 to 2.993 eV/cell were obtained. By application of topological descriptors, namely, the relative disposition of Cd atoms and the number of Cd atoms in the vicinity of Ag vacancy, the reliable correlations were obtained between the Cd/Sn relative disposition and the calculated energy characteristics.
First glance at the tracking detectors data collected in the first BM@N SRC run
Authors: Khabarov Sergey , Kulish Elena , Lenivenko Vasilisa , Makankin Alexander , Maksymchuk Anna , Palichik Vladimir , Patsyuk Maria , Vasiliev Sergey , Vishnevskij Aleksander , Voytishin Nikolay
Published: February 2019

BM@N (Baryonic Matter at Nuclotron) is the first experiment at the accelerator complex of NICA-Nuclotron at JINR (Dubna). The aim of the experiment is to study collisions of relativistic ion beams of the kinetic energy from 1 to 4.5 AGeV with fixed targets. The last run started a new physics program of BM@N – Short Range Correlations (SRC) studies in light nuclei. The BM@N setup allows detecting of the residual nucleus for the first time. BM@N tracking detectors play a key role in the identification of the nucleus after hard scattering in inverse kinematics. We present the first results of the BM@N tracking detectors using the data collected in spring 2018.
Alternative digital filltering scheme for LumiCal read-out
Authors: Lutsenko Evgenii
Published: February 2019

The LumiCal electromagnetic calorimeter is designed for the forward region of future electron-positron colliders, such as CLIC and ILC. It is intended to improve hermeticity of detectors by detecting electrons, positrons, and photons at small angles. Currently, the detector prototypes are studied in the beam test conditions. An important part of the signal processing is the digital filltering implemented in the read-out electronics, influencing the precision and quality of gathered data. In this article two schemes of digital filltering of gathered signal from test beam for the LumiCal detector prototype are presented.
Catch and Prolong: recurrent neural network for seeking track-candidates
Authors: Baranov Dmitriy , Ososkov Gennady , Goncharov Pavel , Tsytrinov Andrei
Published: February 2019

One of the most important problems of data processing in high energy and nuclear physics is the event reconstruction. Its main part is the track reconstruction procedure which consists in looking for all tracks that elementary particles leave when they pass through a detector among a huge number of points, so-called hits, produced when flying particles fire detector coordinate planes. Unfortunately, the tracking is seriously impeded by the famous shortcoming of multiwired, strip and GEM detectors due to appearance in them a lot of fake hits caused by extra spurious crossings of fired strips. Since the number of those fakes is several orders of magnitude greater than for true hits, one faces with the quite serious difficulty to unravel possible track-candidates via true hits ignoring fakes. We introduce a renewed method that is a significant improvement of our previous two-stage approach based on hit preprocessing using directed K-d tree search followed a deep neural classifier. We combine these two stages in one by applying recurrent neural network that simultaneously determines whether a set of points belongs to a true track or not and predicts where to look for the next point of track on the next coordinate plane of the detector. We show that proposed deep network is more accurate, faster and does not require any special preprocessing stage. Preliminary results of our approach for simulated events of the BM@N GEM detector are presented.
Nuclotron injection beam profiles measurement system
Authors: Egorov D. , Elkin V. , Donets D. , Ponkin D.
Published: February 2019

The superconducting synchrotron Nuclotron [1] is the one of the main parts of the NICA/MPD project [2] in the Laboratory of High Energy Physics of JINR in Dubna. During the work on updating the Nuclotron control and monitoring systems the new injection beam profiles measurement system was developed, produced and successfully put into operation. The development process and operation results are described.
Lab-scale evaluation of possible mercury speciation in flue gas and mercury emission from combustion of pulverised solid fuels
Authors: Cholewiński Maciej , Rybak Wiesław
Published: February 2019

In this work a new lab-scale method dedicated to the evaluation of both concentration and oxidation level of mercury in flue gases from pulverised fuel fired boiler was proposed. To detect the abovementioned parameters, 2 main steps need to be evaluated. Firstly, a calorimeter bomb is utilised - by a proper implementation of mass balance of mercury within substrates and products, the quantity of oxidised mercury in gaseous products can be evaluated. Then, to simulate solid fuel fired power unit and to calculate mercury concentrations in flue gases, one of the stoichiometric mathematical models of combustion process must be applied. Early validation of the method showed considerable differences between solid fuels in mercury oxidation efficiencies and concentrations in flue gasses. Four examined fuels (lignite, hard coal and 2 types of solid biomass) was investigated. Calculated mercury concentrations in raw flue gas (>700°C) varied between 4 and 75 µg/m3ref. The lowest quantity of oxidised forms ofHg in flue gases were identified in the case of investigated lignite (27% of total Hg), while significantly higher – for selected hard coal (72%) and one type of biomass (with high chlorine concentration; up to 98%).
Off-Axis Ions Extraction Simulation in Tubular Electron String Ion Source (TESIS)
Authors: Boytsov A.Yu. , Bulychev A.A.
Published: February 2019

Tubular Electron String Ion Source (TESIS) – improved version of Electron String Ion Source (ESIS) aiming for nearly 200-fold increase in ion yield – is under development at JINR. TESIS advantages over ESIS are discussed and their characteristics are compared. Basic scheme of TESIS operation is presented. One of the crucial processes in TESIS – off-axis ion extraction – requires special confilguration of output electrodes providing steep potential gradient. Numerical simulations of ion extraction trajectories for two different electrode confilgurations are compared and the optimal one is discussed. The obtained results will be useful for TESIS design and construction.
Simulation of the dynamics of an intense proton beam in a collider NICA
Authors: Korobitsina Margarita , Kovalenko Alexander , Kolomiets Andrey
Published: February 2019

In the physics of accelerators and colliders there is one important parameter as “impedance”. Impedance determines the level of the influence of the field induced by the beam in the longitudinal and transverse directions on the beam motion. Knowledge of the impedances is necessary for estimating the conditions for the stability of the beam motion in the designed accelerator. Thus, the main objective at the moment is the calculation of the impedance of each device in the collider for further calculation of their contribution to the general impedance. In the report the physics of the beam motion in an accelerator chamber is considered, the method of calculating the impedance - the method of electro-magnetic simulation through the CST Studio Suit software package is described, an example of the calculation of the impedance for the part of vacuum chamber of the quadrupole magnet, which is a part of the arch of the collider NICA is shown.
The functional form of nuclei decay in a thermal point-reactor within the particles' birth and death model
Authors: Kravchenko Maksim , Rudak Eduard , Korbut Tamara , Kuzmin Andrey , Petrovski Andrey
Published: February 2019

The functional form of nuclei decay for a finite number of particles within sub-Poisson distribution terms and time scale discretisation were considered. The mathematical apparatus for particles’ birth and death model with respect to the theory of a nuclear thermal point-reactor was made. During research the fundamental curves, the exponential dependence of neutron generation lifetime and state decay possibility were obtained for a thermal reactor breeding medium. Main parameter of a breeding (neutron multiplication factor K) was obtained through mathematical functions considered.
Outflows and particle acceleration in the accretion disks of young stars
Authors: Khaibrakhmanov Sergey , Dudorov Alexander
Published: February 2019

Magneto-gas-dynamic (MGD) outflows from the accretion disks of T Tauri stars with fossil large-scale magnetic fileld are investigated. We consider two mechanisms of the outflows: rise of the magnetic flux tubes (MFT) formed in the regions of eﬃcient generation of the toroidal magnetic fileld in the disk due to Parker instability, and acceleration of particles in the current layer formed near the boundary between stellar magnetosphere and the accretion disk. Structure of the disk is calculated using our MGD model of the accretion disks. We simulate dynamics of the MFT in frame of slender flux tube approximation taking into account aerodynamic and turbulent drags, and radiative heat exchange with external gas. Particle acceleration in the current layer is investigated on the basis of Sweet-Parker model of magnetic reconnection. Our calculations show that the MFT can accelerate to velocities up to 50 km s-1 causing periodic outflows from the accretion disks. Estimations of the particle acceleration in the current layer are applied to interpret high-speed jets and X-rays observed in T Tauri stars with the accretion disks.
Investigation and Study on the "Dragon Boat Race" of Ankang Folk Sports
Authors: Liu Fenshan , Wei Shilong
Published: February 2019

This paper investigates and studies the "dragon boat race" of folk sports activities in Ankang city to understand the cultural connotation of dragon boat race and the development history of "dragon boat race" in this region. In this paper, the literature review, questionnaire survey, field visits, and statistics and analysis of data are used to investigate and study the current situation of the development of the "dragon boat race" in Ankang. It aims to provide a valuable and meaningful reference for the inheritance and development of the "dragon boat race" movement in Ankang.
Present Situation and Analysis of Yi Nationality Wrestling in Shilin County
Authors: Yan Qiang , Huang Dong
Published: February 2019

Wrestling has a long history, and wrestling activities are deeply loved and respected by the people of Shilin which is known as the "Hometown of Wrestling." With the continuous development and progress of society, Yi Nationality’s wrestling is facing new opportunities as well as new challenges. Through the methods of literature, data statistics, questionnaire, expert interview and logical analysis, this paper studies 50 long-term wrestlers in Shilin County, analyzes the present situation and finds out the existing problems, thus providing the necessary reference for the development of the Yi wrestling sport.
A Study on the Development of Leisure Sports Industry of China’s Sichuan in the Age of Big Data
Authors: Deng Chenliang , Li Liang
Published: February 2019

This paper mainly analyzes the development of leisure sports industry of Sichuan province in big data age in terms of opportunities, challenges, development trends and strategies. In this paper, based on the methods of documentary, interview, questionnaire and logic analysis, combing large data for broad influence and huge benefits of leisure sports industry, and then analyze its development trend and development strategy. The mega data age is expected to bring about favorable opportunities to leisure sports industry of Sichuan province, such as creating more value, contributing to the flexible distribution of resources and to the trend of new ways of thinking in the research on leisure sports industry. Both the application of mega data technology to and the research on the realm of leisure sports industry are faced with drastic challenges. From wide application, the processing mode, precise marketing and personnel training aspects analyzes the development trend of leisure sports industry in the era of big data. We should take corresponding counter-strategies, which include innovating leisure sports industry, implementing full application of mega data technology, increasing the supply of related professional talents, supporting the informatization of leisure sports industry and establishing a platform of information resource for leisure sports industry.
Discussion on Positive Effects for Students’ Moral Development from Integrating Mentors and Doctoral Students into One Party Branch
Authors: Li Wu , Sun Zhenjia
Published: February 2019

The word “mentor” comes from the Odyssey by the Greek poet Homer. Odyssey entrusted his friend Mentor to care for and educate his son, Telemachus.The word “mentor” later refers to a trustworthy advisor, counsellor and friend.A mentoring relationship has been defined as a “nurturing process in which a more skilled or experienced person, serving as a role model, teaches, sponsors, encourages, counsels and befriends a less skilled or less experienced person” (Anderson & Shannon, 1988). This paper mainly focuses on how to successfully mentor the doctoral students through the integration of mentors and doctoral students into one party branch.
Elaboration of the Importance and Necessity of Extracurricular Learning for Students who Major in Ceramic Art Design in Universities
Authors: Yu Fei
Published: February 2019

The requirement for ceramic art professionals is becoming higher and higher from enterprises on the basis of the deep development of market economy. Traditional talent training mode has gradually fallen behind the requirements of the Times, and it is very important to improve students’ time operation skills. It becomes necessary to carry out extracurricular learning in ceramic art major in universities. Only in the process of practice can students develop their comprehensive professional abilities. However, in view of the fact that the ability of university student themselves to obtain extra-curricular learning opportunities is relatively weak, and universities should take the initiative to reform the teaching mode, provide extracurricular learning opportunities for students, construct the teaching mode of combining work with study, in order that students can obtain enough extracurricular learning opportunities.
A Research on the Reform of College English Blended Teaching Mode under the Background of Educational Informatization
Authors: Zhu Lin
Published: February 2019

Nowadays, the rapid development of information technology has increasingly penetrated into all walks of society and even people’s lives. With the development of education informatization, traditional teaching can’t meet the needs of talents in the new era. Developing a new teaching mode by integrating internet, big data and traditional teaching has become the main theme of contemporary education. This paper studies the connotation of educational informatization and Blended Teaching theory and puts forward the Blended Teaching mode of College English by improving teachers’ informationized teaching ability, constructing the diversified teaching platform, and setting up informationized teaching resource base, adopting different teaching methods and strategies, so as to improve students’ enthusiasm and autonomy in College English learning and enhance the effect of College English teaching.
Knowledge Mapping of Researches on China’s Aphids Parasitoids Based on Metrology Analysis with CiteSpace Ⅴ
Authors: Zhang Chao , Liu Changzhong
Published: February 2019

554 papers on China's aphids parasitoids from 1979 to 2018 years were taken from the China National Knowledge Infrastructure as the research samples, which were analyzed using CiteSpace Ⅴ as an analysis tool, to create a knowledge map on the research fields of China's aphids parasitoids and comprehensively analyze the number of publications, core authors and research institutions, research hot topics and research trends, so as to present the current research status of China’s aphids parasitoids and provide a reference for the future researches.
Study on Hospital Medical Information Engineering
Authors: Wang Na , Li Qun
Published: February 2019

On the base of the current status of hospital medical information engineering, this paper analyzes some major problems existing in computer hardware, and puts forward some plans and reform measures in connection with the characteristics of medical information engineering. Because the application of electronic information engineering in hospitals is perfect and comprehensive, and there is no corresponding management training, so that the management personnel do not have the information technology and skills required by the application of electronic information engineering, the training of relevant personnel should be strengthened.
Hospital Information Integration Based on Integration Platform
Authors: Wang Jinguo , Wang Na
Published: February 2019

This paper analyzes the current situation of hospital informatization, and puts forward a new solution to realize the integration of hospital information system to make up the defects of the traditional integration scheme in the current hospital informatization construction. Medical information integration and data sharing are realized by building a unified hospital information integration platform based on HL7 standards, SOA architecture and ESB technology. Each independent medical information subsystem is closely linked through the hospital information integration platform. On the base of the open architecture, the integration platform has strong scalability and supportsthe connection of customized adapters and the application of complex heterogeneous systems, so as to realize the data sharing and information collaboration among various hospital systems.
Numerical Simulation of Welding Process for Q235 Steel Plate
Authors: Yang Yukun
Published: February 2019

In this paper, the weld of Q235 steel pipe with diameter of 60 mm and thickness of 4 mm is simulated and analyzed by MSC. Marc software. After modeling, applying material physical properties, setting weld bead and welding path, and applying boundary conditions, the operation results are analyzed and processed by submitting the work. According to the simulation results, different joints are selected to study the thermal cycle process and temperature distribution of joints under different joints.
Research and Analysis of the Development Approaches in E-Business Mobile Application
Authors: Xing Yongkang
Published: February 2019

With e-Business rapidly spreads out in recent years, there is a significant trend that more and more consumers are using mobile applications in engaging with e-Commerce. In order to reach out to maximum consumers across diverse mobile platforms, how to choose a suitable e-Commerce mobile application development approaches with reliable compatibility and lower cost becomes a challenging solution. This paper starts with describing an overview of various development approaches in the field of e-Commerce mobile applications. The research will focus on examining the performance of e-Business mobile applications in terms of access to mobile features, advanced graphics and compatibility are developed using such frameworks. By analyzing the research data on several platforms, this paper will list the pros and cons in each development approaches under different commercial criteria. Finally, the paper summarizes the contributions and concludes with some possible future e-Commerce mobile development directions.
The Two-Axis Linkage System Design of CNC Machine Based on PLC
Authors: Wang Qian , Huo Zhiyi
Published: February 2019

This essay gives an introduction to the design of control procedures to realize the linkage of axis X and axis Y of CNC machine by the use of PLC movement control module, and thereby to accomplish making complicated curved surfaced parts and simulate multi-axis linkage processing environment. This system has developed specially corresponding positioning module point at movement for NC X and Z axis, it can simplify the design process greatly, can improve the machining accuracy and effective. in addition, the control module may reduce the production cost and dilution procedure, at the same time, this system can greatly save operation time and is suitable for wide popularization.
Experimental Study on the Peeling Characteristics of Wax on the Surface of Flexible Composite Pipe and Plastic Alloy Tube
Authors: Liu Wei , Li Yu , Wu Yan , Gu Xinjun , Wen Ziyan , Deng Zhian , Yi Kai
Published: February 2019

In this paper, the wax deposition stripping experiment on the surface of flexible composite tube and the surface of plastic alloy tube was carried out by using medical paraffin. Under different temperature and different thickness of wax, the peeling force of wax on the surface of flexible composite pipe and the surface of plastic alloy pipe lining was discussed. The experimental conclusions of this study are specific guidance for wax cleaning technology in nonmetallic pipes and device design.
Estimation of accurate size, lattice strain using Williamson-Hall models, SSP and TEM of Al doped ZnO nanocrystals
Authors: Bodke Milind , Gawai Umesh , Patil Ashok , Dole Babasaheb
Published: February 2019

Hexagonal structure of pure and Al doped ZnO nanocrystals were synthesized by co-precipitation technique. The average crystallite size determined from XRD data using Debye Sherrer’s formula was found to be 16.8 nm for pure 19.3 nm for 4% Al Doped ZnO. High-resolution transmission electron microscopy (HR-TEM) showed single-crystal ZnO nanocrystals with nearly spherical shapes. The W-H analysis and size-strain plot were used to study the individual contributions of crystallite sizes and lattice strain “ε” on the peak broadening of pure and Al doped ZnO nanocrystals. The physical parameters namely strain, stress and anisotropic energy density were calculated considering uniform deformation model (UDM), uniform stress deformation model (USDM) and uniform deformation energy density model (UDEDM) of modified form of W-H analysis. Texture coefficient was estimated using XRD data. The average crystallite size of pure and Al doped ZnO samples estimated from W-H model. It is also revealed from the TEM the diameters of as synthesized samples are in good agreement with the W-H model analysis.
Muscle type temporomandibular disorders and orthodontics
Authors: Gil H.
Published: February 2019

With painful temporomandibular disorders, the physiotherapist treatment makes it possible to treat the pains and dysfunctions of the masticatory apparatus. When these are diagnosed before orthodontic treatment, it is necessary to treat them so that they do not interfere with the dentofacial orthopaedics treatment. In this perspective, lingual rehabilitation according to the method «Fournier» is associated with Schultz Autogenic Training.
Aminosäuren und chronische Erschöpfung – Welche Möglichkeiten zur Besserung gibt es?
Authors: Meister Doris
Published: February 2019

Dauerstress kann physische, psychische und kognitive Auswirkungen haben, das soziale Verhalten beeinflussen und sich in einer endokrinen Insuffizienz manifestieren. Eine aktuelle Studie an Personen mit chronisch-psychologischer Stressbelastung und Erschöpfung untersuchte den Einfluss einer definierten Aminosäuren-Mineralstoffmischung auf das Stressempfinden und die endokrin-kardiometabolische Situation. In der Verumgruppe zeigten sich ein signifikanter Rückgang des subjektiv wahrgenommenen Stresses sowie ein positiver Einfluss auf serotonerges System und Magnesiumstoffwechsel. Unter Placebo kam es zu einem Anstieg von kardiometabolischen Risikofaktoren.
Metabolic Tuning statt Doping: Ausgewählte Mikronährstoffe im Leistungssport
Authors: Gröber Uwe
Published: February 2019

Eine unzureichende Versorgung mit Mikronährstoffen resultiert bei Sportlern in einer geringeren Leistungs- und Regenerationsfähigkeit sowie einer erhöhten Infektanfälligkeit. Wegen ihrer Bedeutung für Energiehaushalt, Wachstum und Leistungsfähigkeit der Muskulatur sowie bei der Sauerstoffverwertung haben u. a. Vitamin D, Kalium, Eisen und Aminosäuren zentralen Stellenwert im Leistungssport. Mangelzustände aufgrund gesteigerten Bedarfs oder erhöhter Ausscheidung mit Schweiß und Urin sind durch angepasste Ernährung und Supplementierung auszugleichen, um sportliche und mentale Leistungsfähigkeit des Athleten zu optimieren.
Fallbericht 39-jährige III. Gravida, III. Para mit Inversio uteri nach Steißgeburt
Authors: Findeklee Sebastian
Published: February 2019

Die Inversio uteri bezeichnet das Umstülpen der Gebärmutter in die Scheide postpartal. Sie ist äußerst selten, aber stellt einen geburtshilflichen Notfall dar. Die Gefahr für die Gebärende besteht in einer Uterusatonie mit dem Verlust großer Mengen Blut in kurzer Zeit. Dies kann, wenn keine rechtzeitige Therapie erfolgt, zum hypovolämischen Schock bis zum Herz-Kreislaufversagen führen. Die Therapie erfolgt durch eine Uterus-Reposition in Vollnarkose mit anschließender manueller Plazentalösung. Anschließend folgen die Kürettage und die Gabe von hochpotenten Uterotonika wie Sulproston. Durch den in der Regel hohen Blutverlust kommt es häufig zu einer Störung des Gerinnungssystems, sodass eine Substitution von Antifibrinolytika wie Tranexamsäure, Gerinnungsfaktoren und/oder Erythrozytenkonzentraten erforderlich wird. Gelingt keine vaginale Reposition des Uterus, so bleiben als Ultima Ratio nur die Reposition per Laparotomie oder die Hysterektomie. Wir berichten über eine 39-jährige III. Gravida, III. Para mit 36+3 Schwangerschaftswochen (SSW), bei der es nach spontaner Steißgeburt bei Placenta accreta zur Inversio uteri kam, die vaginal reponiert werden konnte.
Akute myeloische Leukämie bei Erwachsenen – Ein Update zu Diagnostik, Risikoklassifikation und Therapie
Authors: Spiekermann Karsten , Shen Anne-Sophie
Published: February 2019

Mittlerweile sind viele neuartige und zielgerichtete Substanzen in der Therapie der AML verfügbar. Durch die Fortschritte in der Molekulargenetik lassen sich zielgerichtete Therapieoptionen ableiten. Umso wichtiger sind eine präzise und vor allem rasche zyto- und molekulargenetische Charakterisierung der AML sowie die Risikobestimmung. Dieser Beitrag legt den Schwerpunkt auf Neuerungen in der Klassifikation und bei den Therapieansätzen.
Chronische Myeloische Leukämie
Authors: Hochhaus Andreas , Eigendorff Ekkehard , Ernst Thomas
Published: February 2019

Vom fachlichen Standpunkt aus gesehen, stellt die chronische myeloische Leukämie (CML) eine Modellerkrankung für Diagnostik und Therapie neoplastischer Erkrankungen dar. Die zugrundeliegende zytogenetische Aberration, das Philadelphia-Chromosom mit der Genfusion sowie der mehrstufige Verlauf ermöglichen es, molekular-zytogenetische Erkenntnisse auf die klinische Anwendung zu übertragen. Dabei spielen nicht nur „Meilensteine“ eine Rolle.
Erfolgreiche Zelltherapie mit virusspezifischen T-Zellen vom HLA-teilkompatiblen Drittspender bei disseminierter Adenovirus-Infektion früh nach allogener Stammzelltransplantation
Authors: Kafa Kinan , Tischer Sabine , Heuft Hans-Gert , Blasczyk Rainer , Priesner Christoph , Klusmann Jan-Henning , Eiz-Vesper Britta , Maecker-Kolhoff Britta
Published: February 2019

Adenovirus-Infektionen (AdV-Infektionen) nach pädiatrischer hämatopoetischer Stammzelltransplantation sind häufig und treten in 10 – 20 % aller allogenen Transplantationen auf (bis 30 % der T-Zell-depletierten Transplantationen). Sie sind mit einer hohen Rate an Morbidität und Mortalität verbunden. Da die antivirale Therapie nur virostatisch wirkt und durch erhebliche Toxizität eine limitierende Behandlungsoption darstellt, ist die virusspezifische T-Zell-Therapie als sichere und gut verträgliche komplikationsarme Option sehr attraktiv. Unsere 4-jährige Patientin entwickelte 3 Wochen nach allogener hämatopoetischer Transplantation vom 10/10-HLA-passenden Registerspender eine disseminierte AdV-Infektion (Enteritis, persistierendes Fieber, Sepsis). Eine antivirale Therapie mit Cidofovir zeigte eine gute Wirksamkeit, musste aber wegen erheblicher Nephrotoxizität abgebrochen werden. Unter einer Überbrückungstherapie bis zur geplanten Gabe AdV-spezifischer T-Zellen mit Brincidofovir (BCV) stabilisierte sich die AdV-Last im Blut, blieb aber signifikant hoch. AdV-spezifische T-Zellen der HLA-haploidenten Mutter wurden nach Stimulation mit AdV-Hexon-Peptid-Gemisch über Interferon-γ-Zytokinsekretion (Interferon-γ: IFN-γ) und immunmagnetische Separation aufgereinigt und 1-malig in einem Frischpräparat mit einer Dosis von 2,5 × 104CD3+-Zellen/kg Körpergewicht verabreicht. Die Anwendung verlief komplikationslos und führte zu einer schnellen Elimination des Virus im Blut (ca. nach 2 Wochen). Nahezu zeitgleich (ca. 3 Wochen nach der AdV-spezifischen T-Zell-Gabe) konnten erstmals AdV-spezifische T-Zellen im Patientenblut nachgewiesen werden. Der adoptive Transfer AdV-spezifischer T-Zellen vom HLA-teilpassenden Familienspender als „Third-Party-Spender“ stellt eine rasch verfügbare und wenig toxische Behandlungsoption für Patienten mit refraktärer AdV-Erkrankung dar.
Cochlear Implantation for Single-Sided Deafness: A New Treatment Paradigm
Authors: Zeitler Daniel , Dorman Michael
Published: February 2019

Unilateral severe-to-profound sensorineural hearing loss (SNHL), also known as single sided deafness (SSD), is a problem that affects both children and adults, and can have severe and detrimental effects on multiple aspects of life including music appreciation, speech understanding in noise, speech and language acquisition, performance in the classroom and/or the workplace, and quality of life. Additionally, the loss of binaural hearing in SSD patients affects those processes that rely on two functional ears including sound localization, binaural squelch and summation, and the head shadow effect. Over the last decade, there has been increasing interest in cochlear implantation for SSD to restore binaural hearing. Early data are promising that cochlear implantation for SSD can help to restore binaural functionality, improve quality of life, and may faciliate reversal of neuroplasticity related to auditory deprivation in the pediatric population. Additionally, this new patient population has allowed researchers the opportunity to investigate the age-old question “what does a cochlear implant (CI) sound like?.”
Semi-classical solutions for fractional Schrödinger equations with potential vanishing at infinity
Authors: An Xiaoming , Peng Shuangjie , Xie Chaodong
Published: February 2019

We study the following fractional Schrödinger equation ε2s(−Δ)su+Vu=|u|p−2u, x∈ RN. We show that if the external potential V∈C(RN;[0,∞)) has a local minimum and p∈(2 + 2s/(N − 2s),2s*), where 2s*=2N/(N − 2s),N≥2s, the problem has a family of solutions concentrating at the local minimum of V provided that lim inf|x|→∞V(x)|x|2s > 0. The proof is based on variational methods and penalized techniques.
Nanokelvin DC and AC Meissner-transition-edge temperature detectors
Authors: Woods S. I. , Carter A. C. , Jung T. M. , Defibaugh D. R.
Published: February 2019

Based upon a superconducting transition edge sensor (TES), the Meissner-TES is a relatively new type of high resolution cryogenic thermometer which employs the magnetic transition of a superconductor to measure temperature. We have improved the signal-to-noise for DC sensing by a factor of 30 compared to our prior effort and developed a new AC mode which uses an oscillating magnetic field and a lock-in technique with much lower magnetic noise than the DC mode. The thermometer was tuned in situ over a range of operating temperatures 10–50 times larger than the transition width of the superconductor, using an applied persistent magnetic field. The DC mode can have sensitivity better than 1 nK for 100 s averaging, and the AC mode has sensitivity better than 120 nK for very small applied magnetic fields near 14 nT and 100 s averaging. The Meissner-TES can be applied to high resolution temperature control, high sensitivity infrared sensing, optical power scale realization, and the study of temperature-dependent phase transitions.
The two-dimensional kinetic ballooning theory for trapped electron mode in tokamak
Authors: Xie T. , Zhang Y. Z. , Mahajan S. M. , Wu F. , He Hongda , Liu Z. Y.
Published: February 2019

The two-dimensional (2D) kinetic theory for a collisionless trapped electron mode is developed based on the Fourier-ballooning transform in an up-down symmetric equilibrium (illustrated via concentric circular magnetic surfaces). The system consists of two equations: the ballooning (integral) equation with a parameterized Floquet phase and a second order differential equation for the distribution of the Floquet phase. The coupled equations are, then, numerically solved as an eigenvalue problem yielding the 2D mode structure (in real space) as well as the global (phase-independent) eigenvalue for an L-mode parameter set. The 2D mode structure exhibits apparent radial-poloidal asymmetry; due to the poloidal coupling, the radial correlation length is found to be, at least, twice as large as the poloidal one. The global (phase-independent) eigenvalue of the mode differs considerably from the conventional local (phase-dependent) estimate. This paper shares many technical aspects with a published paper that works out the 2D kinetic theory for the ion temperature gradient mode [Xie et al., Phys. Plasmas 24, 102506 (2017)].
Direct visualization of the 3D structure of silicon impurities in graphene
Authors: Hofer Christoph , Skakalova Viera , Monazam Mohammad R. A. , Mangler Clemens , Kotakoski Jani , Susi Toma , Meyer Jannik C.
Published: February 2019

We directly visualize the three-dimensional (3D) geometry and dynamics of silicon impurities in graphene as well as their dynamics by aberration-corrected scanning transmission electron microscopy. By acquiring images when the sample is tilted, we show that an asymmetry of the atomic position of the heteroatom in the projection reveals the non-planarity of the structure. From a sequence of images, we further demonstrate that the Si atom switches between up- and down- configurations with respect to the graphene plane, with an asymmetric cross-section. We further analyze the 3D structure and dynamics of a silicon tetramer in graphene. Our results clarify the out-of-plane structure of impurities in graphene by direct experimental observation and open a route to study their dynamics in three dimensions.
An adaptive calibration technique of timing skew mismatch in time-interleaved analog-to-digital converters
Authors: Gao Jian , Ye Peng , Zeng Hao , Song Jinpeng , Wei Wentao , Yang Kuojun
Published: February 2019

Because of the exponential increase of sampling rate, time-interleaved analog-to-digital converter (TIADC) has a fast growth in the high-speed applications. However, the channel mismatch error is a serious challenge for the performance of TIADC. In this article, we address the timing skew mismatch error and propose a novel adaptive calibration method. The principle and operating process of the calibration algorithm are explained. To validate the proposed technique, we designed a four-channel TIADC-based digital oscilloscope with a sampling rate of 10 GS/s. Based on this instrumentation platform, (i) calibration algorithm was implemented by hardware; and (ii) a test platform consisting of advanced instruments and tools was setup to testify the effect and robustness of proposed algorithm. Moreover, the technical details of instrumentation are described for the first time. The experimental results show that the calibration algorithm significantly suppresses the distortions due to timing skew mismatch error. The TIADC-based instrumentation achieves spurious-free dynamic range of 52.48 dB and effective number of bits of 5.83 bit, respectively. Besides, the complexity of the proposed algorithm is compared and discussed.
Control of optical polarization properties by manipulation of anisotropic
strain in nonpolar m-plane GaInN/GaN quantum wells
Authors: Ketzer Fedor Alexej , Horenburg Philipp , Farr Philipp , Korn Ernst Ronald , Bremers Heiko , Rossow Uwe , Hangleiter Andreas
Published: February 2019

We report on the control of optical polarization properties of nonpolar m-plane Ga1–xInxN/GaN quantum wells by manipulation of anisotropic in-plane strain via the insertion of a partially relaxed AlInN interlayer prior to the quantum wells. Structures with different interlayer compositions are compared to m-plane quantum wells without interlayers as reference. With these interlayers, we are able to either decrease or increase the strain in the quantum wells, as well as change the strain in just one in-plane direction to further change the anisotropy of strain. This results in a modified valence band structure which strongly influences optical properties such as the degree of optical polarization. Systematic evaluation of the polarization splittings opens up the opportunity to experimentally determine the deformation potential D5 for different anisotropic strain states for indium contents between 13% and 37%, which provides a good estimate for D5 for InN. Finally, we compare the measurements to k ⋅ p calculations, using the deformation potential derived from the experiments.
Comparison of probe and narrow-band imaging measurements in a magnetized cylindrical plasma
Authors: Light A. D. , Chakraborty Thakur S. , Tynan G. R.
Published: February 2019

We analyze similarities and differences between electrostatic probe measurements and high-speed visible light imaging measurements in a low-temperature argon helicon plasma. Electrostatic probes are the usual diagnostics for making fluctuation measurements in low-temperature plasmas, although fast-imaging of visible emission is becoming increasingly common. The two diagnostics are highly complementary, and typical analysis takes fluctuations in both ion saturation current and visible light intensity to be proxies for plasma density fluctuations. The observations presented here indicate that care is needed in applying this approximation. The plasma is produced with a helicon antenna, and we measure fluctuations in ion saturation current, floating potential, and visible emission near wavelengths of 488 nm (argon ions) and 750 nm (argon neutrals). Simultaneous measurements show relatively low correlation values between ion saturation current and ion line emission and an anti-correlation between floating potential and ion line emission. Variations in cross-coherence between ion emission and probe quantities indicate the frequency dependence in the relationship between the measurements. For various frequency bands where probe/imaging coherence is relatively high, fluctuation intensity profiles differ significantly and coherent fluctuations are observed in ion light which are not apparent in the probe measurements. A sensitivity analysis indicates that electron temperature fluctuations, although nearly always neglected when analyzing data from low-temperature plasma experiments, may play a role in the discrepancy between probe and narrow-band imaging measurements.
Spectroscopic investigation of stagnation region in laterally colliding plasmas: Dependence of ablating target material and plasma plume separation
Authors: Mondal Alamgir , Kumar Bhupesh , Singh R. K. , Joshi H. C. , Kumar Ajai
Published: February 2019

The effect of the atomic mass of the ablating target on the formation and expansion of the interaction region in laterally colliding plasmas has been studied. Fast imaging and optical emission spectroscopy have been utilized as diagnostic tools to investigate the characteristic features of the seed plasma as well as interaction zone formed by different target materials (i.e., carbon, aluminium, and nickel). The present results reveal that dynamical, spectral, and geometrical features of the induced interaction zone depend on the mass of the ablated species and spatial separation between the interacting plumes. It has been observed that a sharp, intense, and more directional interaction zone is formed by the interaction of heavier plume species in comparison to that observed for a lighter atomic mass target. Further, the difference in the plasma parameters in seed and interaction regions are explained from the analysis of emission from both the regions for aluminium plasma.