bluuebunny/crossref_metadata_2025 huggingface dataset:
Nothing but Gold. Complexities in Terms of Non-difference and Identity. Part 3. Permanence, Properties Plexuses and Subtleties in Mutual Exclusion
Authors: Anrò Alberto
Published: February 2022

This paper investigates Vācaspati Miśra’s remarkably complex argumentative architecture in support of non-difference by means of a microsimulation model, the classical gold-crown case. A full range of positions, including instantaneism, transformative continuum, indeterminate common basis reference, difference and non-difference coordination, etc., is put under the scrutiny of the Vācaspati Miśra’s dialectic effort. The possibility of coexistence of multiple properties with a single referent is then formally explored. The analysis is carried out in compliance with the ‘Navya-Nyāya Formal Language’ extensional set-based approach and its non-predicative, and variables free, relational syntax. Repeatable modules and structures of reasoning are identified and designed in the form of hypothesis frameworks, axioms and theorems to allow more accurate inferences, in particular regarding transformation and permanence, together with possible or impossible plexuses of properties. Identity and difference qua mutual absence are thoroughly defined with the aid of these formal tools, which conjointly might cast new light on the heuristic and expressive power of Navya-Nyāya logic, as well as on the theoretical potentialities of the non-dualistic account.
Improved osteoblast function on titanium implant surfaces coated with nanocomposite Apatite–Wollastonite–Chitosan– an experimental in-vitro study
Authors: Mukherjee Shayanti , Sharma Smriti , Soni Vivek , Joshi Amruta , Gaikwad Amit , Bellare Jayesh , Kode Jyoti
Published: February 2022

Background

There is a continuous research in the area of biomimetic coatings on the titanium (Ti) implant surfaces for improved survival and long-term successful outcomes in the field of dentistry and orthopedics. In-vitro approaches are ideal systems for studying cell-material interactions without complexity and interference observed in in-vivo models.

Purpose

The present study was undertaken to evaluate the osteoblast characteristics and function on Ti substrates coated with the novel composite coating of ceramic apatite-wollastonite (AW) and polymer chitosan.

Materials and methods

Ti substrate coated with composite AW-Chitosan was synthesized, using electrophoretic deposition. MG-63 cells were seeded onto the coated substrates and cellular morphology and growth was assessed using Scanning Electron Microscopy (SEM) and Laser Scanning Microscopy (LSM). Osteocalcin expression of the seeded cells was assessed by FITC tagging and LSM analysis. Alizarin Red S staining and Confocal LSM (CSLM) analysis was used to study the in-vitro mineralization on the titanium samples.

Results

The AW-Chitosan coating on Ti samples by electrophoretic deposition exerted significant positive influence on cell proliferation, growth and mineralization as compared to uncoated titanium samples. Scanning electron microscopy and laser confocal microscopy experiments revealed that the coating was non-toxic to cells, enhanced adhesion and proliferation of MG-63 cells. Increased functional activity was observed by increased production of bone-specific protein osteocalcin and mineralized calcium through day 7 and 14.

Conclusions

The present study underscores that optimal inorganic-organic phase nanocomposite crack-free coating created on Ti by simple, cost-effective electrophoretic deposition technique may have osteoconductive potential and may have wide application in the field of implantology.
A Scoping Review and Appraisal of AAC Research in Inclusive School Settings
Authors: Iacono Teresa , Goldbart Juliet , Douglas Sarah N. , Garcia-Melgar Ana
Published: February 2022

The aim of this scoping review was to explore the extent to which AAC studies have occurred in inclusive versus segregated settings, the role of AAC in inclusive setting studies, and the evidence for AAC supporting inclusive education of students with complex communication needs. A scoping review of studies published from 2000 to 2020 that involved students who used or could benefit from AAC or their peers conducted within schools yielded 167 studies. Relatively few studies (n=28, 17%) were conducted in inclusive settings. Data from these 28 studies were extracted and appraised for quality. AAC was integrated into intervention in 57% of these studies and in 61% improved use of AAC was an outcome variable, but in only six was this the main aim. Eighty-two students who used or could benefit from AAC were participants across studies. Classroom peers participated across 11 studies, including those in which qualitative designs were employed. The strength of evidence for the role of AAC could not be determined because only 12 studies were experimental and addressed varied aims. Nonetheless, these and seven qualitative studies were appraised as being of high quality. Implications of findings are discussed in terms of extending the evidence to demonstrate the role of AAC, and its potential to support academic and social school inclusion of students with complex communication needs, which may not rely on proficient use of AAC.
Scalarization and robustness in uncertain vector optimization problems: a non componentwise approach
Authors: Caprari Elisa , Cerboni Baiardi Lorenzo , Molho Elena
Published: February 2022

The robust optimization approach can be used to tackle uncertain vector problems by considering worst case scenarios. In this context, notions of robust efficient solutions which are coherent with a set-valued minimization process have been introduced in literature in order to avoid unduly pessimistic attitudes (see e.g. Ehrgott et al. in Eur. J. Oper. Res. 239(1), 17–31, 2014). We address the question whether scalarization and robustification can be commuted in a non componentwise framework. We prove that the commutation of the two approaches is ensured under appropriate assumptions. To this purpose, we identify a class of scalarization processes that ensure necessary and sufficient robust optimality conditions through the direct scalarization of the uncertain vector optimization problem, without explicitly passing through the set-valued formulation of the problem.
Analysing dynamic deep stall recovery using a nonlinear frequency approach
Authors: Nguyen Duc H. , Lowenberg Mark H. , Neild Simon A.
Published: February 2022

Based on bifurcation theory, nonlinear frequency response analysis is a recent development in the field of flight dynamics studies. Here, we consider how this method can be used to inform us on how to devise the control input such that the system transitions from an undesirable equilibrium solution—an aircraft deep stall solution in our case—to a desirable solution. We show that it is still possible to induce a large-amplitude oscillation via harmonic forcing of the pitch control device and escape the otherwise unrecoverable deep stall, despite very little control power available in such a high angle-of-attack flight condition. The forcing frequencies that excite these resonances are reflected as asymptotically unstable solutions using bifurcation analysis and Floquet theory. Due to the softening behaviour observed in the frequency response, these unstable (divergent) solutions have slightly lower frequencies than the value predicted using linear analysis. Subharmonic resonances are also detected, which are reflected in the time-domain unforced responses. These nonlinear phenomena show strong dependency on the forcing/perturbation amplitude and result in complex dynamics that can impede recovery if the existing procedures are followed. The proposed method is shown to be a useful tool for nonlinear flight dynamics analysis as well as to complement the rather thin literature on deep stall analysis—a topic of relevance for recent research on unconventional landing techniques in unmanned aerial vehicles. A full description of the aircraft model used, the unstable F-16 fighter jet, is provided in the appendix.
A review of methods to evaluate crop model performance at multiple and changing spatial scales
Authors: Pasquel Daniel , Roux Sébastien , Richetti Jonathan , Cammarano Davide , Tisseyre Bruno , Taylor James A.
Published: February 2022

Crop models are useful tools because they can help understand many complex processes by simulating them. They are mainly designed at a specific spatial scale, the field. But with the new spatial data being made available in modern agriculture, they are being more and more applied at multiple and changing scales. These applications range from typically at broader scales, to perform regional or national studies, or at finer scales to develop modern site-specific management approaches. These new approaches to the application of crop models raise new questions concerning the evaluation of their performance, particularly for downscaled applications. This article first reviews the reasons why practitioners decide to spatialize crop models and the main methods they have used to do this, which questions the best place of the spatialization process in the modelling framework. A strong focus is then given to the evaluation of these spatialized crop models. Evaluation metrics, including the consideration of dedicated sensitivity indices are reviewed from the published studies. Using a simple example of a spatialized crop model being used to define management zones in precision viticulture, it is shown that classical model evaluation involving aspatial indices (e.g. the RMSE) is not sufficient to characterize the model performance in this context. A focus is made at the end of the review on potentialities that a complementary evaluation could bring in a precision agriculture context.
Philosophers’ appraisals of bibliometric indicators and their use in evaluation: from recognition to knee-jerk rejection
Authors: Feenstra Ramón A. , Delgado López-Cózar Emilio
Published: February 2022

The knowledge and stance of researchers regarding bibliometric indicators is a field of study that has gained weight in recent decades. In this paper we address this issue for the little explored areas of philosophy and ethics, and applied to a context, in this case Spain, where bibliometric indicators are widely used in evaluation processes. The study combines data from a self-administered questionnaire completed by 201 researchers and from 14 in-depth interviews with researchers selected according to their affiliation, professional category, gender and area of knowledge. The survey data suggest that researchers do not consider bibliometric indicators a preferred criterion of quality, while there is a fairly high self-perception of awareness of a number of indicators. The qualitative data points to a generalised perception of a certain rejection of the specific use of indicators, with four main positions being observed: (1) disqualification of the logic of metrics, (2) scepticism about the possibility of assessing quality with quantitative methods, (3) complaints about the incorporation of methods that are considered to belong to other disciplines, and (4) criticism of the consequences that this generates in the discipline of philosophy.
Convective Acceleration in Porous Media
Authors: Gjengedal S.
Published: February 2022

Convective acceleration occurs in porous media flows due to the spatial variations of the nonuniform flow channel geometry of natural pores. This article demonstrates that the influence of convective acceleration in a nonuniform a pore channel is analogous to that of a constricting pipe channel. Their fluid mechanical behaviour can be comparable, provided that their geometrical characteristics are described precisely in the same manner, and from the same point of reference with regards to the fluid velocity in the flow channels. The analogy of the dissipation mechanisms in nonlinear porous media flow to the "minor loss" approach in fluid mechanics of pipes is therefore appropriate. Conventional nonuniform pipe channel geometries obtain dissipation coefficients within the range 0 < CKL < 0.2. These pipe geometries are relevant reference points for natural porous media, and it is thus expected that most natural pore geometries will obtain values within this range. This assumption holds true for the nine different 3D porous media samples presented here. However, the results show that the rate of change in the pore geometry, and consequently the magnitude of induced convective acceleration, depends on: the area ratio a of the pore channel, the angle of approach θ and the rounding of the pore channel geometry. The rounding of the pore channel reduces the dissipation coefficient, as the rate of change becomes smoother along the channel length. The results also indicate that the pore tortuosity increase the magnitude of nonlinear dissipation, in good agreement with pipe flow behaviour. This knowledge can help improve our interpretation of experimental data and enhance the predictability of porous media equations that incorporate the appropriate dissipation coefficients CKL as a variable.

Article Highlights

The analogy of porous media flow to the "minor loss" approach in fluid mechanics of pipes is appropriate, and the angle of approach θ and the area ratio a of the pore channel govern the magnitude of induced convective acceleration in porous media

The rounding of the pore channel geometry reduces the magnitude of induced convective acceleration

The tortuosity of a pore influences the dissipation coefficient CKL and increase the magnitude of induced convective acceleration
Overexpression of m6A-factors METTL3, ALKBH5, and YTHDC1 alters HPV16 mRNA splicing
Authors: Cui Xiaoxu , Nilsson Kersti , Kajitani Naoko , Schwartz Stefan
Published: February 2022

We report that overexpression of the m6A-demethylase alkB homolog 5 RNA demethylase (ALKBH5) promoted production of intron retention on the human papillomavirus type 16 (HPV16) E6 mRNAs thereby promoting E6 mRNA production. ALKBH5 also altered alternative splicing of the late L1 mRNA by an exon skipping mechanism. Knock-down of ALKBH5 had the opposite effect on splicing of these HPV16 mRNAs. Overexpression of the m6A-methylase methyltransferase-like protein 3 (METLL3) induced production of intron-containing HPV16 E1 mRNAs over spliced E2 mRNAs and altered HPV16 L1 mRNA splicing in a manner opposite to ALKBH5. Overexpression of the nuclear m6A-“reader” YTH domain-containing protein 1 (YTHDC1), enhanced retention of the E6-encoding intron and promoted E6 mRNA production. We also show that HPV16 mRNAs are bound to YTHDC1 in human cells and that YTHDC1 affected splicing of HPV16 E6/E7 mRNAs produced from the episomal form of the HPV16 genome. Finally, we show that HPV16 mRNAs are m6A-methylated in tonsillar cancer cells. In summary, HPV16 mRNAs are methylated in HPV16-infected tonsillar cancer cells and overexpression of m6A-“writer” METTL3, m6A-“eraser” ALKBH5 and the m6A-“reader” YTHDC1 affected HPV16 mRNA splicing, suggesting that m6A plays an important role in the HPV16 gene expression program, at least in cancer cells.
Satisfaction with HyFlex Teaching and Law-abiding Leadership Education in Hong Kong University Students Under COVID-19
Authors: Shek Daniel T. L. , Zhu Xiaoqin , Li Xiang , Dou Diya
Published: February 2022

Since the early days of COVID-19, university teaching has changed from face-to-face format to online mode. With the gradual containment of the pandemic, there is no need for school lockdown. As a result, the teaching format has changed to HyFlex mode integrating both face-to-face and online modes. Obviously, it is necessary to understand the academic quality of life among students under the Hyflex teaching mode. In this paper, we report an evaluation study on a leadership subject in Hong Kong delivered via HyFlex teaching using a post-lecture evaluation strategy. In one of the lectures, we covered law-abiding leadership in university students, including abiding by the Hong Kong National Security Law. The post-lecture evaluation showed that students generally held positive views toward the HyFlex teaching and they perceived that the subject promoted their well-being indexed by psychosocial competence. Regarding the lecture on law-abiding leadership, students agreed that the lecture promoted their psychosocial competence, personal development, knowledge about law-abiding behavior and national security (including the Hong Kong National Security Law), and readiness to serve as socially responsible leaders. Positive perceptions of the lecture design, teacher performance, lecture content of law-abiding leadership and national security, and benefits positively predicted students’ overall satisfaction with the lecture on law-abiding leadership and national security.
Financial sustainability: measurement and empirical evidence
Authors: Gleißner Werner , Günther Thomas , Walkshäusl Christian
Published: February 2022

Financial sustainability is underrepresented in both the research on and practice of sustainability management and reporting. This article proposes a conceptual measure of financial sustainability and examines its association with capital market returns. The measure is positioned at the intersection of sustainability management, risk management and risk governance. Financial sustainability is regarded as a crucial control parameter complementing shareholder value and can be viewed by risk-averse investors as a secondary condition of investment decisions. It reduces refinancing and insolvency risks, leading to risk-adjusted excess returns in an imperfect capital market with financing restrictions and insolvency costs. We propose measuring a firm’s financial sustainability in terms of four conditions: (1) firm growth, (2) the company’s ability to survive, (3) an acceptable overall level of earnings risk exposure, and (4) an attractive earnings risk profile. We show that the application of a conditions-based investment strategy to European firms with high financial sustainability (i.e., firms fulfilling all four conditions) over the period from July 1990 to June 2019 results in monthly excess returns of 0.39%. This portfolio’s risk is lower than the risk of market investment. We find that the excess returns increase when incrementally adding each of the four conditions to the investment strategy.
Sustainability science must challenge common sense: a response to Bodin (2021)
Authors: Isgren Ellinor , Longo Stefano B.
Published: February 2022

In this comment, we respond to the claim of (Bodin, Sustain Sci 16: 2151–2155, 2021) that sustainability science, as a research community, has begun to “lean to the left” in a problematic manner. On one hand, we remain unconvinced by the examples cited as indications for this tendency, and argue for caution in making such judgements. On the other hand, we hold that that there may be reasons for seemingly “left leaning” positions which are scientific rather than purely political or ideological. Finally, we urge sustainability scientists to take heed of social theorists’ insights regarding the pitfalls of common sense analysis. This can better enable open and reflexive debate on the field’s development as well as the challenges it seeks to address.
Discursive dynamics and lock-ins in socio-technical systems: an overview and a way forward
Authors: Simoens Machteld Catharina , Fuenfschilling Lea , Leipold Sina
Published: February 2022

Understanding the dynamics of stability and change is key to accelerate sustainability transitions. This paper aims to advance and inspire sustainability transition research on this matter by collecting insights from interpretative environmental discourse literature. We develop a heuristic that identifies and describes core discursive elements and dynamics in a socio-technical system. In doing so, we show how the interplay of meta-, institutionalized, and alternative discourses, dominant, marginal, and radical narratives, as well as weak and strong discursive agency influence the socio-technical configuration. The heuristic suggests three discursive lock-ins reinforcing the stabilization of socio-technical systems: unchallenged values and assumptions, incumbents’ discursive agency, and narrative co-optation. Furthermore, it explores three pathways of discursive change: disruptive, dynamic and cross-sectoral. Overall, this paper puts forward a discursive perspective on sustainability transitions. It offers additional analytical approaches and concepts for discursive transition studies, elaborated insights on the dynamics within and between the analytical dimensions of a socio-technical system, as well as a theoretical baseline for analyzing discursive lock-in mechanisms and pathways of discursive change.
Humus horizon development during natural forest succession process in the Polish Carpathians
Authors: Sokołowska Justyna , Józefowska Agnieszka , Zaleski Tomasz
Published: February 2022

As a result of socio-economic changes and land abandonment, the main ecological driver of the Carpathian landscape is the progression of the natural forest succession process. Thus, aspects of this process have become worthy of attention, especially in the context of carbon sequestration and the management of protected areas. Soil processes, especially within the topsoil, are some of the most susceptible to change, due to the accumulation of organic matter during such land-use transformations. The purposes of this study were to investigate the differences in topsoil development using the A Horizon Development Index (ADI) and to study the composition of humic substances and advanced organic matter humification in different land-use areas in selected Carpathian national parks, i.e. Bieszczady, Magura and Pieniny National Parks in southern Poland. Additionally, a goal of this study was to compare the ADI and the spectroscopic coefficients of humic substances as indicators of the degree of humus horizon shaping as well as advanced organic matter humification. In total, ten transects were selected, each consisting of three different land-use areas: semi-natural meadow, successional forest and old-growth forest. Soil colour was determined in fresh and air-dried samples using the Munsell colour chart. In air-dried soil samples pH, soil texture, total organic carbon and total nitrogen were measured. Humic substances were extracted and further characterized by UV-VIS spectroscopy. The ADI confirmed the influence of natural forest succession on soil colour darkening and the development of the uppermost soil layer. Spectroscopic analyses of humic substances showed two different patterns depending on soil depth. In the 0–10 cm layer, natural forest succession reduced the rate of the humification process and decreased the degree of maturity of fulvic acids; in the 10–20 cm layer, it led to an increase in the rate of the humification process and a decrease in the content of humic and fulvic acids at the beginning of the transformation. The comparison of two different indicators of soil development — the ADI and the spectroscopic coefficients of humic substances (Q4/6,Q2/4,Q2/3, Δ logK) — indicated that these indexes are based on different features of soil and cannot be used interchangeably.
Overexpression of Programmed Cell Death 1 Prevents Doxorubicin-Induced Apoptosis Through Autophagy Induction in H9c2 Cardiomyocytes
Authors: Kanno Syu-ichi , Hara Akiyoshi
Published: February 2022

Doxorubicin (DOX) is a potent chemotherapeutic agent; however, it causes severe heart injury via apoptosis induction in many patients. DOX-induced cardiotoxicity is attenuated by activated autophagy in the heart. We previously found that programmed cell death 1 (Pdcd1), an immune checkpoint receptor, inhibits DOX-induced cardiomyocyte apoptosis. In this study, we investigated whether autophagy contributes to the protective role of Pdcd1 against DOX-induced cardiomyocyte apoptosis. We also examined the role of Pdcd1 in DOX-induced apoptosis in cancer cells. Rat cardiomyocyte cell line H9c2 and human cancer cell lines K562 and MCF-7 were transfected with Pdcd1-encoding plasmid DNA to establish Pdcd1-overexpressing cells. Apoptosis and autophagy were determined using a luciferase assay. In H9c2 cells, DOX-induced apoptosis and viability reduction occurred through caspase activation. In particular, Pdcd1 overexpression activated the autophagy pathway through the inhibition of the mammalian target of rapamycin, a major negative regulator of autophagy. Moreover, it prevented DOX-induced cardiomyocyte apoptosis; a similar cardioprotection was observed when normal H9c2 cells (without Pdcd1 overexpression) were treated with rapamycin, an autophagy inducer, before the DOX treatment. Conversely, in cancer cells, Pdcd1 overexpression increased both basal and DOX-induced apoptosis. The role of Pdcd1 in DOX-induced apoptosis in cardiomyocytes and cancer cells was opposing. Pdcd1 signaling prevented DOX-induced apoptosis in cardiomyocytes, through autophagy induction; it enhanced DOX-induced apoptosis in cancer cells. Therefore, Pdcd1 could be a critical molecule for more effective and safer DOX chemotherapy.
Cross-Country and Gender Differences in Factors Associated with Population-Level Declines in Adolescent Life Satisfaction
Authors: Marquez Jose , Inchley Joanna , Long Emily
Published: February 2022

Adolescent subjective well-being, including life satisfaction, has shown declines at national level across many countries in recent years. Although several possible explanatory factors have been identified, there is a lack of research on whether these may be similar or different across countries. Using data on 15-year-old adolescents from the Programme for International Student Assessment study in Scotland, England, Wales, Northern Ireland, the United States, Japan, Ireland and France in 2015 and 2018, we find that changes in school well-being and, to a lesser extent, the use of Information and Communication Technologies and material well-being were associated with observed declines in life satisfaction. Although there are similarities across some countries, cross-country differences in factors associated with decreasing life satisfaction emerged, notably between Western nations and Japan, with some gender differences also evident.
The role of industrial actors in the circular economy for critical raw materials: a framework with case studies across a range of industries
Authors: Cimprich Alexander , Young Steven B. , Schrijvers Dieuwertje , Ku Anthony Y. , Hagelüken Christian , Christmann Patrice , Eggert Roderick , Habib Komal , Hirohata Atsufumi , Hurd Alan J. , Lee Min-Ha , Peck David , Petavratzi Evi , Tercero Espinoza Luis A. , Wäger Patrick , Hool Alessandra
Published: February 2022

In this article, we explore concrete examples of circularity strategies for critical raw materials (CRMs) in commercial settings. We propose a company-level framework for systematically evaluating circularity strategies (e.g., material recycling, product reuse, and product or component lifetime extension) in specific applications of CRMs from the perspectives of specific industrial actors. This framework is applied in qualitative analyses—informed by relevant literature and expert consultation—of five case studies across a range of industries: (1) rhenium in high-pressure turbine components, (2) platinum group metals in industrial catalysts for chemical processing and oil refining, (3) rare earth permanent magnets in computer hard disk drives, (4) various CRMs in consumer electronics, and (5) helium in magnetic resonance imaging (MRI) machines. Drawing from these case studies, three broader observations can be made about company circularity strategies for CRMs. Firstly, there are multiple, partly competing motivations that influence the adoption of circularity strategies, including cost savings, supply security, and external stakeholder pressure. Secondly, business models and value-chain structure play a major role in the implementation of circularity strategies; business-to-business models appear to be more conducive to circularity than business-to-consumer models. Finally, it is important to distinguish between closed-loop circularity, in which material flows are contained within the “focal” actor’s system boundary, and open-loop circularity, in which material flows cross the system boundary, as the latter has limited potential for mitigating material criticality from the perspective of the focal actor.
Coordinating Centers as a Strategy for Accelerating Cancer Epidemiology Consortia: Best Practices
Authors: Trentham-Dietz Amy , Bird Jennifer E. , Gangnon Ronald E. , Lindberg Sara M. , Madison Tena , Malecki Kristen M. C. , Shull James D. , Vredeveld Claudia , Rolland Betsy
Published: February 2022

Purposeof Review

This review highlights six “best practices” for cancer epidemiology coordinating centers to facilitate the success of a research consortium.

Recent Findings

Evidence from emerging literature regarding the Science of Team Science suggests that coordinating centers can more effectively foster collaborative cancer epidemiology research in consortia by (1) establishing collaboration as a shared goal at the start, (2) providing scientific expertise complementary to the research sites that adapts over the course of the project, (3) enacting anti-racist and inclusive approaches in all consortium decisions and activities, (4) fostering early-stage investigator career development, (5) engaging stakeholders including cancer survivors as peers, and (6) delivering reliable logistical support and technology tools with planned process evaluation so that researchers can collaboratively focus on the science.

By drawing on the Science of Team Science, coordinating centers can accelerate research progress and increase the impact of cancer epidemiology consortia.
Terapia ormonale sostitutiva e osteoporosi postmenopausale
Authors: Lello Stefano , Scambia Giovanni , Capozzi Anna
Published: February 2022

Sommario

L’osteoporosi postmenopausale è un processo per il quale il tessuto osseo sviluppa una fragilità risultando più suscettibile alle fratture anche per traumi che solitamente non comporterebbero tali eventi. La carenza estrogenica è un punto fondamentale nella patogenesi dell’osteoporosi. La TOS rappresenta un trattamento di scelta nella prevenzione della osteoporosi e delle fratture correlate, soprattutto nei primi anni di postmenopausa.
A highly active and stable Sr2Fe1.5Mo0.5O6-δ-Ce0.8Sm0.2O1.95 ceramic fuel electrode for efficient hydrogen production via a steam electrolyzer without safe gas
Authors: Wang Yao , Liu Tong
Published: February 2022

High temperature steam (H2O) electrolysis via a solid oxide electrolysis cell is an efficient way to produce hydrogen (H2) because of its high energy conversion efficiency as well as simple and green process, especially when the electrolysis process is combined with integrated gasification fuel cell technology or derived by renewable energy. However, about 60%–70% of the electricity input is consumed to overcome the large oxygen potential gradient but not for electrolysis to split H2O to produce H2 due to the addition of safe gas such as H2 in the fuel electrode. In this work, Sr2Fe1.5Mo0.5O6-δ-Ce0.8Sm0.2O1.95 (SFM-SDC) ceramic composite material has been developed as fuel electrode to avoid the use of safe gas, and the open circuit voltage (OCV) has been effectively lowered from 1030 to 78 mV when the feeding gas in the fuel electrode is shifted from 3%H2O–97%H2 to 3%H2O–97%N2, reasonably resulting in a significantly increased electrolysis efficiency. In addition, it is also demonstrated that the electrolysis current density is greatly enhanced by increasing the humidity in the fuel electrode and the working temperature. A considerable electrolysis current density of − 0.54 A/cm2 is obtained at 800 °C and 0.4 V for the symmetrical electrolyzer by exposing SFM-SDC fuel electrode to 23%H2O–77%N2, and durability test at 800 °C for 35 h demonstrates a relatively stable electrochemical performance for steam electrolysis under the same operation condition without safe gas and a constant electrolysis current density of − 0.060 A/cm2. Our findings achieved in this work indicate that SFM-SDC is a highly promising fuel electrode for steam electrolysis.
Knowledge resources and the acquisition of spinouts
Authors: Adams Pamela , Fontana Roberto , Malerba Franco
Published: February 2022

In high-technology industries, employee spinouts have increasingly been identified as attractive targets for acquisitions. Yet employee spinouts may originate from different knowledge contexts. This study adopts a resource base perspective to examine the impact of both the knowledge heritage and the product strategy of spinouts originating from different contexts (i.e. from the same industry or from a related downstream industry) on the potential to be acquired by firms in the same industry or in related industries. Our findings, based on data from the semiconductor industry and its related downstream industries, show that spinouts from firms in a focal industry represent appealing targets for a broad range of buyer firms from within the focal industry or from related, downstream industries, independent of their product strategy at entry. By contrast, spinouts from downstream, user industries that enter into an upstream industry, tend to appeal to a more limited set of buyers. Our study suggests that managers and academics should consider the acquisition of spinouts whose founders have origins in related industries as a channel to access critical knowledge from upstream or downstream contexts. Yet because many of the critical knowledge resources that spinouts possess are embodied in their founders, such acquisitions also require careful management of personnel decisions post-acquisition.
Intelligent Prediction of Cryptogenic Stroke Using Patent Foramen Ovale from TEE Imaging Data and Machine Learning Methods
Authors: Bai Jiao , Yang Jia , Song Wanwan , Liu Yumin , Xu Haibo , Liu Yang
Published: February 2022

In spite of the popularity of random forests (RF) as an efficient machine learning algorithm, methods for constructing the potential association for between patent foramen ovale (PFO) and cryptogenic stroke (CS) using this technique are still barely. For the vital regional study areas (atrial septum), RF was used to predict CS in patients with PFO using partial clinical data of patients and remotely sensed imaging examination data obtained from Tee imaging. We validated our method on a dataset of 151 consecutive patients with detected PFO at a large grade A hospital in China from November 2018 to December 2020, we obtained an area under the relative operating characteristic curve of 0.816, with 65% specificity at 73% sensitivity. The RF models accurately represented the relationship between the CS and remotely sensed predictor variables. Therein, maximum mobility, large right-to-left shunt during Valsalva maneuver, size of PFO in diastole and systole, and diastolic length of the tunnel present higher predictive value in CS. Our findings suggest that multi-Doppler sensor data by transesophageal echocardiography (TEE)-detected morphologic and functional characteristics of PFO may play important roles in the occurrence of CS. These results indicate that the established random forest model has the potential to predict CS in patients with PFO and great promise for application to clinical practice.
Clostridioides difficile infection following dental antibiotic prescriptions in a cohort of US veterans
Authors: Wilson Geneva M. , Evans Charlesnika T. , Fitzpatrick Margaret A. , Poggensee Linda , Gibson Gretchen , Jurasic M. Marianne , Echevarria Kelly , Suda Katie J.
Published: February 2022

Among 108 (0.05% of cohort) US veterans with a Clostridioides difficile infection (CDI) within 30 days of a dental antibiotic prescription, 80% of patients received guideline-discordant antibiotics. Half had chronic gastrointestinal illness potentially exacerbating their CDI risk. More efforts are needed to improve antibiotic stewardship.
EUCLIDEAN NUMBERS AND NUMEROSITIES
Authors: BENCI VIERI , LUPERI BAGLINI LORENZO
Published: February 2022

Several different versions of the theory of numerosities have been introduced in the literature. Here, we unify these approaches in a consistent frame through the notion of set of labels, relating numerosities with the Kiesler field of Euclidean numbers. This approach allows us to easily introduce, by means of numerosities, ordinals and their natural operations, as well as the Lebesgue measure as a counting measure on the reals.
“Not just for their own use …”: Solidarity in Times of Discord
Authors: Solovieva Olga V.
Published: February 2022

In May 2015, I happened to visit Frankfurt am Main, where during my haphazard exploration of the city I blindly strolled into the building of the Bockenheimer Depot where a new opera was to premiere that evening. It was entitled “Am unseren Fluße” (By Our River), as I saw on the banner outside, and I thought it would be something ecological. I was more interested in the building than in the show, but the decorations of which I could get a glimpse from the lobby and an animated Bohemian crowd drew me in. It turned out to be a powerfully moving piece allegorizing the Israeli-Palestinian conflict, and by extension all human territorial conflicts of that kind, bringing out the absurdity inherent in all territorial claims, profiteering by third parties, humanity’s shared frailty, and love that transcends this all. Some reviewers later referred to it as a “Middle Eastern Romeo and Juliet.”
Policing Insecurity
Authors: LAKE MILLI
Published: February 2022

In environments of seemingly intractable conflict, how should we understand the role of state capacity building and security-sector reform in transitions to peace? Prevailing wisdom suggests that a strong state security apparatus mitigates cyclical violence and aids in transitions to predictable, rule-governed behavior. Yet growing attention to police brutality in institutionalized democracies calls this assumption into question. Drawing on a multiyear study of war making and state making in eastern DR Congo, this article interrogates logics of police capacity building, analyzing how and why reform efforts intended to bolster the state’s monopoly on violence frequently fail to curb the unrest they seek to disrupt. I argue that enhancing the coercive capacity of the police can entrench a wartime political order that makes peace more elusive; when police deploy the image of the state toward destabilizing ends they reinforce the institutions of everyday war, undermining the stability a monopoly on violence is intended to build.
Measuring the value of data governance in agricultural investments: A case study
Authors: Whittard Damian , Ritchie Felix , Musker Ruthie , Rose Michael
Published: February 2022

The study at hand measures the value of improving data governance and access in the Supporting Soil Health Interventions (SSHI) project in Ethiopia. We applied two separate but interlinked models, one qualitative and one quantitative, to create a new framework enhancing the traditional cost–benefit analysis. The qualitative analysis provided novel insights into the specific types of value and the mechanisms through which they are generated. These results underpinned the development of an innovative framework to measure this perceived value quantitatively. By combining the quantitative and qualitative framework, the study demonstrated that it is possible to generate plausible and credible quantitative estimates of both costs and benefits of data governance and access. While acknowledging that the estimates are only illustrative, the case study results suggested on a direct cost measure, at a particular point in time, the SSHI data governance activities yielded a negative return. However, indirect social and public benefits are rarely quantified, but this paper shows that relatively few “indirect” benefits (current but unmeasured, or measurable but in the future) are necessary to reverse that view, at least from the point of the economy more generally.
Necrotaboos and Political Afterlives in Social Justice Activism during Mexico's Day of the Dead
Authors: Ohlson Olof
Published: February 2022

This article shows how vulnerable communities use Mexico's Day of the Dead for social justice activism. Activists sustain what I call the ‘political afterlives’ of their victims through street altars and dark humour. I analyse this as a ‘necrosocial repertoire of contention’. The Day of the Dead can play an important role in human rights advocacy by insisting that the marginalised dead be honoured and cared for. However, disappeared people pose a challenge to Mexico's horizontal, or popular, ethics of commemoration and illustrate what I call ‘necrotaboos’, with new problems for the nation's inclusive spirit of commemorating the dead.
Limited influence of experimentally induced predation risk on granivory in a tropical forest
Authors: Granados Alys , Bernard Henry , Brodie Jedediah F.
Published: February 2022

Seed predation by rodents can strongly influence plant recruitment and establishment. The extent to which predation risk indirectly alters plant survival in tropical forests via impacts on granivory is unclear, making it difficult to assess the cascading impacts of widespread predator loss on tree recruitment and species composition. Experimental field studies that manipulate predation risk can help address these knowledge gaps and reveal whether antipredator responses among small mammals influence plant survival. We used camera traps and seed predation experiments to test the effects of perceived predation risk (via predator urine gel) on foraging behaviour of and seed removal by murid rodents in an unlogged and unhunted rainforest in Malaysian Borneo. We also explored the influence of seed traits (e.g., seed size) on removal by granivores and assessed whether granivore preferences for particular species were affected by predator urine. Murid visits to seed plots were positively related to overall seed removal, but were not affected by predator scent. Granivory was the lowest for the largest-seeded (>6 g) plant in our study, but was not influenced by predation risk. Predator urine significantly affected removal of one seed taxon (Dimoocarpus, ∼0.8 g), suggesting that removal by granivores may be affected by predation risk for some seed species but not others. This could have implications for plant species composition but may not affect the overall level of granivory.
A method for estimating the number of collision candidates in two waterways – for all intersection angles
Authors: Kaneko Fujio
Published: February 2022

Estimating the collision frequency of ships (F) is important for assessing collision risk on waterways. To date, F has been estimated as the product of the number of collision candidates $({N_{a }})$ and the causation probability $({P_c})$: $F = {N_{a}} \cdot {P_c}$, where ${N_{a }}$ represents the number of collisions that occur when related ships continue on course with no intervention, and ${P_c}$ is the probability that collision avoidance fails. Fujii developed a general method and Pedersen formulated it to estimate ${N_{a }}$ in an intersectional area. Their method is generally called ‘the geometric method’ because collision candidates are estimated only from the geometric relationship between two ships. The method has been used in many projects to estimate F in waterways; however, its use should be limited to intersection angles ranging from 10° to 170°. This paper presents a method, statistically verified by computer simulation, that can be used at all intersection angles to overcome this limitation. Moreover, it demonstrates strong agreement with Pedersen's method at intersection angles of 10° to 170°.
‘Scotland’s fighting fields’: the mobilisation of workers in rural Scotland during the Second World War
Authors: Moffat Michelle
Published: February 2022

As the Battle of the Atlantic threatened Britain’s importation of food and forestry supplies, authorities intensified plans to rapidly increase domestic production. In Scotland, this was a herculean task in rural communities decimated by land clearances, economic depression, and population decline. Against the odds, the mobilisation of a range of workers enabled Scottish agriculture and forestry to make impressive gains in production, and significantly impacted Scotland’s ability to meet wartime production targets. This article examines the contributions of four diverse groups of labourers that toiled in Scottish fields and forests: compelled labourers, including conscientious objectors and prisoners of war; adult and child volunteers; women; and foreign lumberjacks from Canada, Newfoundland, and British Honduras. This original research supplements our knowledge of the British rural workforce during the Second World War, and raises the issue of wartime migration and its effects on rural communities.
Becoming Through Milling: Challenging Linear Economic Narratives in Medieval England
Authors: Jervis Ben
Published: February 2022

The relationship between handmilling, undertaken in domestic contexts, and mechanized mills in medieval Kent is used to challenge linear approaches to economic progress in the Middle Ages. Inspired by posthuman perspectives which emphasize messiness, non-linearity and multiplicity, medieval economic development is re-imagined as a patchwork of intensive material processes. In so doing, an approach is developed which works towards dissolving problematic binaries between gendered labour, domestic and economic spheres and the Middle Ages and modernity.
NOVA food groups’ consumption associated with nutrient intake profile of school children aged 8–12 years
Authors: de Lacerda Arabele Teixeira , do Carmo Ariene Silva , Maia de Sousa Taciana , dos Santos Luana Caroline
Published: February 2022

Objective:

To evaluate the association between the consumption of NOVA food groups (classification based on the nature, extent and purpose of food processing) and the intake of energy, macro and micronutrients among school children.

Design:

Cross-sectional study. Food consumption was assessed by two 24-h dietary recalls on non-consecutive days. Energy from each NOVA food groups – ultra-processed foods, unprocessed or minimally processed foods, processed culinary ingredients and processed foods – was estimated. For analysis, the percentage of energy from ultra-processed foods and unprocessed or minimally processed foods were categorised into tertiles and associated with intake of energy, macro and micronutrients using analysis of covariance and linear regression.

Setting:

Public schools in Belo Horizonte, Minas Gerais, Brazil.

Participants:

School children aged 8–12 years (n 797; 406 girls; 391 boys).

Results:

Mean energy intake was 2050·18 ± 966·83 kcal/d, 25·8 % was from ultra-processed foods, 56·7 % from unprocessed or minimally processed foods, 8·9 % from processed culinary ingredients and 8·6 % from processed foods. A higher energy contribution from ultra-processed foods was negatively associated with the intake of protein, fibre, vitamin A, Fe and Zn (P < 0·001) and positively associated with total energy, lipid and Na intake (P < 0·001). Concurrently, a higher energy contribution from unprocessed or minimally processed foods was positively associated with the consumption of protein, fibre, Fe and Zn (P < 0·001) and negatively associated with total energy (P = 0·002), lipid and Na intake (P < 0·001).

Conclusions:

In conclusion, higher ultra-processed food consumption presented a negative association with the nutrient intake profile of school children.
Kant and Religion Roundtable
Authors: Wood Allen
Published: February 2022

This article provides a summary and some replies to points offered in the Kantian Review Roundtable discussion of my recent book Kant and Religion. The main themes are as follows: Kant’s project in the Religion; religious thinking as symbolic; the rational interpretation of revelation and of religious symbols; Kant’s moral argument for religious faith; the ‘psychological’-moral argument; Kant’s thesis that human nature contains a radical propensity to evil; evil and human sociability; evil and freedom; divine forgiveness and the sinner’s self-acceptance; Kant’s Religion as a subject of philosophical controversy.