bluuebunny/crossref_metadata_2025 huggingface dataset:
TRIF/EGFR signalling mediates angiotensin-II-induced cardiac remodelling in mice
Authors: Zhu Hong , Cao Wei , Zhao Peng , Wang Jieyu , Qian Yuying , Li Yun
Published: June 2020

The excessive activation of renin-angiotensin system (RAS) is one of key pathophysiological characteristics in the development of cardiac remodelling. Angiotensin (Ang) II, as a main active peptide in RAS, induces cardiac structural disorders and dysfunction. However, the molecular mechanisms are still not fully disclosed. Present study aimed to determine the role and potential mechanisms of cardiac TIR-domain-containing adapter-inducing interferon-β (TRIF) in Ang-II-mediated cardiac remodelling in mice. In vitro and in vivo studies showed Ang II and downstream aldosterone obviously increased the expression of TRIF, accompanied with cardiac structural abnormalities and functional injuries. Specific blockage of cardiac TRIF effectively decreased Ang-II/aldosterone-induced cardiac inflammation, fibrosis, hypertrophy and dysfunction in mice. Mechanistically, the TRIF triggered the activation of EGF receptor (EGFR) signalling by nuclear factor (NF)-κB transcriptional regulation and downstream EGFR ligands. Taken together, present study supported that cardiac TRIF was a potential therapeutic target for attenuating cardiac pathophysiological remodelling. The TRIF/EGFR axis partially explained the molecular mechanism of Ang-II/aldosterone-induced cardiac inflammation, fibrosis, hypertrophy and dysfunction in mice.
On maximal Kn domains for certain families of rational functions
Authors: Kiriyatzkii Jevgenij , Kiriyatzkii Eduard
Published: June 2020

Let Kn(D) be a class of analytic in domain D functions such that [F(z); z0,...,zn] for any z0,...,zn ∈ D. The domain D is called by maximal Kn-domain of the family T of functions which are analytic in D, if for any neighborhood ε(ψ) of any boundary point ψ of D there exists a function from T which does not belong to Kn(D \smile ε(ψ)). The maximal domain of univalence, i.e., maximal K1 domain was investigated by Bulgarian mathematician L. Chakalov. In this paper as maximal Kn-domains the angular domains are examined. Kn-domains for two special classes of rational functions are established.
On calculation of recursive M- and GM-estimates in LQG control systems
Authors: Pupeikis Rimantas
Published: June 2020

The aim of the given paper is development of a parametric identification approach for a closedloop system when the parameters of a discrete-time linear time-invariant (LTI) dynamic system as well as that of LQG (Linear Quadratic Gaussian) controller are not known and ought to be calculated. The recursive techniques based on an the maximum likelihood(M) and generalized maximum likelihood(GM) estimator algorithms are applied here in the calculation of the system as well as noise filter parameters. Afterwards, the recursive parameter estimates are used in each current iteration to determine unknown parameters of the LQG-controller, too. The results of numerical simulation by computer are discussed.
Analysis of usage of genetic and tabu search algorithms in shop scheduling
Authors: Šakurovas Edgaras , Listopadskis Narimantas
Published: June 2020

A wide area of scheduling problem is industrial so-called shop scheduling (Job Shop, Flow Shop and Open Shop) which has important applications in real world industrial problems. Metaheuristic algorithms(Genetic and Tabu search algorithms in this case) seem to be one of the best candidates for finding nearbyoptima in proper time. In this work we implemented several genetic algorithms (separated by values oftheir parameters) and several Tabu search algorithms (separated by neighborhood of solution). Finally, implemented eight algorithms are examined for random shop scheduling problems in terms of variouscriteria.
Mixed genetic algorithm for optimization of trusses
Authors: Šešok Dmitrij
Published: June 2020

In this paper two strategies of optimization are compared: sequential and synchronous topology and shape optimization of trusses. Genetic algorithms are used for optimization. A task of optimization of truss withtwelve possible nodes is solved. Finite elements method is used to calculate an objective function value. Software used in calculations was created by the author.
Restrictions for loop-check in sequent calculus for temporal logic
Authors: Birštunas Adomas
Published: June 2020

In this paper, we present sequent calculus for linear temporal logic. This sequent calculus uses efficient loop-check techinque. We prove that we can use not all but only several special sequents from the derivation tree for the loop-check. We use indexes to discover these special sequents in the sequent calculus. These restrictions let us to get efficient decision procedure based on introduced sequent calculus.
Loop-check elimination for non-transitive distributed knowledge logic
Authors: Pliuškevičienė Aida
Published: June 2020

A non-transitive distributed knowledge logic TnD, obtained from multi-modal logic Tn by adding distributed knowledge operator, is considered. Sound and complete loop-check-free sequent calculus for this logic is proposed. Termination of derivations in proposed calculus is justified.
Estimation of employed persons in the case of sample rotation
Authors: Chadyšas Viktoras , Krapavickaitė Danutė
Published: June 2020

The aim of the paper – to investigate effectiveness of the ratio estimator in the labour force survey in the case of the simple random sampling with rotation. For each quarter of the year one fourth of the previousquarter sample is changed with the new one, and three fourth’s are remaining the same. After simplification of the sampling design the estimator using auxiliary information and its approximate variance is constructed. The accuracy of the estimator obtained is studied by modelling with the real data.
Empirical study of relation measures of stable distributed stock returns
Authors: Belovas Igoris , Kabašinskas Audrius , Sakalauskas Leonidas
Published: June 2020

Relationships between financial instruments are very important in practical portfolio management. Under the assumption of stability, when the second moment does not exist, traditional relationship measures cannot be applied. In this paper we introduce new general correlation measures. Results of the empirical analysis of the selected equities from Baltic States market are given as an example.
On network traffic statistical analysis
Authors: Kaklauskas Liudas , Sakalauslas Leonidas
Published: June 2020

The present article deals with statistical university network traffic, by applying the methods of self-similarity and chaos analysis. The object of measurement is Šiauliai University LitNet network node maintaining institutions of education of the northern Lithuania region. Time series of network traffic characteristics are formed by registering amount of information packets in a node at different regimes of network traffic and different values of discretion of registered information are present. Measurement results are processed by calculating Hurst index and estimating reliability of analysis results by applying the statistical method. Investigation of the network traffic allowed us drawing conclusions that time series bear features of self-similarity when aggregated time series bear features of slowly decreasing dependence.
Epsilon-projection method for two-stage SLP
Authors: Sakalauskas Leonidas , Žilinskas Kęstutis
Published: June 2020

In this paper, a stochastic adaptive method with the ε-projection for stochastic gradient has been developed to solve two-stage stochastic linear problems. The method is based on the adaptive regulation of the size of Monte-Carlo samples and a statistical termination procedure taking into consideration the statistical modelling accuracy. To avoid “jamming” or “zigzagging” in solving the constraint problem the procedure for stochasticgradient epsilon-projectionhas been implemented. Four algorithms of the epsilonprojection are tested by the computer simulation. The recommendationsto solve two-stage stochasticlinear problems are made under the numerical study and results of solving the test examples.
An empirical study of the structure of the shortest path tree
Authors: Bloznelis Mindaugas , Radavičius Irmantas
Published: June 2020

We consider a complete graph on n vertices. Edges of the graph are prescribed random positive weights X1, X2, . . ., Xm. Here m = (n/2). We assume that these random variables are independent and have the common probability distribution with density function f (x), x \geq 0. Given a vertex v let T denote the shortest path tree with root v. Let T1, T2, . . . ⊂ T denote the trees that are obtained from T after removal of  the root v. Let N1 \geq N2 \geq  N3  \geq . . . denote (ordered) sequence of sizes of these trees. We study statistical properties of this sequence for various densities f and large n.
Integration of GIS Web Services
Authors: Paliulionis Viktoras
Published: June 2020

The number of GIS web services has been essentially increasing in recent years. The services encompass geospatial data providing and processing. GIS web services enable application developers to integrate GISfunctionality into their web applications without having to build the functionality or host the mapping data locally. The integration of services from different providers enables creating more sophisticated servicesand applications. This paper analyzes peculiarities of GIS web services, and discusses ways of their integrating. In order to investigate issues of implementing distributed GIS web services, a prototype of a system was designed and implemented. The system integrates public map services and our specialized GIS Akis-WS services. This paper describes specific features and architecture of this system.
On new stability estimations in Ramachandran–Rao characterization
Authors: Januševičius Romanas , Januševičienė Olga
Published: June 2020

B. Ramachandran and C.R. Rao have proved that if X, X1, X2, . . ., Xn are i.i.d. random variables and if distributions of sample mean \bar X = \bar X(n) = (X1 + ··· + Xn)/n and monomial X are coincident at least at two points n = j1 and n = j2 such that log j1/ log j2 is irrational, then X follows a Cauchy law. Assuming that condition of coincidence of \bar X(n) and X are fulfilled at least for two n values, but only approximately, with some error ε in metric λ, we prove that, in certain sense, characteristic function of X is close to the characteristic function of the Cauchy distribution and construct stability estimation.
Poisson-type approximation for sums of 1-dependent indicators
Authors: Kelmelytė Jūratė , Čekanavičius Vydas
Published: June 2020

The sum of 1-dependent indicators is approximated by two-parametric Poisson type signed measure. Estimates are obtained for the local and total variation norms.
On estimation of the Hurst index of solutions of stochastic integral equations
Authors: Kubilius Kęstutis , Melichov Dmitrij
Published: June 2020

Let X be a solution of a stochasti Let X be a solution of a stochastic integral equation driven by a fractional Brownian motion BH and let Vn(X, 2) = \sumn k=1(\DeltakX)2, where \DeltakX = X( k+1/n ) - X(k/n ). We study the

ditions n2H-1Vn(X, 2) convergence almost surely as n → ∞ holds. This fact is used to obtain a strongly consistent estimator of the Hurst index H, 1/2 < H < 1.
The discounted local limit theorems for large deviations
Authors: Saulis Leonas , Deltuvienė Dovilė
Published: June 2020

Theorems of large deviations, both in the Cramer zone and the Linnik power zones, for the normal approximation of the distribution density function of normalized sum Sv = \sum∞ k=0 vkXk, 0 < v < 1, of i.i.d. random variables (r.v.) X0, X1, . . . satisfying the generalized Bernstein’s condition are obtained.
Problems of Lithuanian olympiad’08
Authors: Mačys Juozas Juvencijus
Published: June 2020

The problems of the Lithuanian mathematical school olympiad-2008are presentedand solutions are given.
Some ways to increase learning possibilities for full and hard-hearing people
Authors: Zajančkauskienė Lina
Published: June 2020

Lithuanian educational strategic provision states that the present poses completely new social, pedagogic and subject requirements for teachers; they must have good information and communication skills. Therefore, we should help teachers, provide relevant materials for education, and allow them to learn the newest things. The paper deals with problems of teaching pupils that have special needs – dull and hard-hearing pupils and ICT for teaching them. Some possibilities and problems are discussed – ICT integration into learning progress, problems that may occur while applying the program „Link-it“, problems while localizing similar software for dull and hard-hearing people.
Twenty articles in didactics of mathematics by Pranas Mašiotas
Authors: Ažubalis Algirdas
Published: June 2020

For many years, Pranas Mašiotas (1863–1940) was engaged as a teacher of mathematics, a director of gymnasium and a vice-minister of education. He compiled a number of mathematical manuals for Lithuanian primary and secondary schools. In twenty articles in mathematical didactics, published in the 30s of the 20th century, P. Mašiotas discussed upon the didactic issued that were most topical for teachers of mathematics in the said period.
Studies development in Vilnius University the faculty of Mathematics and Informatics 1946–2008
Authors: Verikaitė Vitolda
Published: June 2020

Article surveys the development of faculty (-ies). Statistics tables are made according to catalog of graduates.
R/S financial market analysis
Authors: Danilenko Svetlana
Published: June 2020

This work discusses the application of R/S analysis to financial markets. The most of the work is devoted to the calculation of Hurst parameter. The Hurst parameters of the Baltic state shares indices are presented.
Kernel regression on matrix patterns
Authors: Daniušis Povilas , Vaitkus Pranas
Published: June 2020

In this paper we propose a kernel-based regression model for matrix patterns (KRMP). The training algorithm is derived. The proposed model was empirically compared with traditional models.
Modelling of finances of Vilnius University
Authors: Eidukevičius Rimantas , Ivanauskas Feliksas , Pikturna Aleksas
Published: June 2020

The dynamics of Vilnius university budget, professors and students is presented. The model consists of three discrete time equations. The parameters were estimated and the solutions exhibit nonstable behavior what suggests necessity of external intervention.
The Effect of Circumcision on Exclusive Breastfeeding, Phototherapy, and Hospital Length of Stay in Term Breastfed Newborns
Authors: O’Callahan Cliff , Te Silena , Husain Aaftab , Rosener Stephanie E. , Hussain Naveed
Published: June 2020

BACKGROUND AND OBJECTIVES:

Little is known about the effect of circumcision on breastfeeding in the hours and days after the procedure. Factors with the potential to negatively impact breastfeeding success in the newborn period may result in higher rates of jaundice requiring phototherapy and formula supplementation, both of which can potentially extend the length of initial hospitalization. Our objective was to determine the impact of circumcision on rates of exclusive breastfeeding, neonatal jaundice requiring phototherapy, and length of stay at hospital discharge immediately after birth.

METHODS:

Term male newborn infants whose mothers intended to exclusively breastfeed were included in this retrospective cohort. Bivariate analysis and multivariate logistic regression modeling were used to evaluate target behaviors, comparing infant boys who were circumcised with those who were uncircumcised.

RESULTS:

Of the 1109 breastfed male newborns included, 846 (76.6%) were circumcised. There was no significant effect of circumcision status or circumcision timing on the rate of in-hospital formula supplementation. There were no differences in peak bilirubin levels, phototherapy requirement, or length of hospital stay for male newborns based on circumcision status.

CONCLUSIONS:

Circumcision did not affect the rate of exclusive breastfeeding, neonatal jaundice, phototherapy requirement, or length of hospital stay in this retrospective analysis of breastfed male newborns.
Transitions to Outpatient Care After Traumatic Brain Injury for Hispanic Children
Authors: Jimenez Nathalia , Fuentes Molly , Frias-Garcia Mariana , Crawley Deborah , Moore Megan , Rivara Frederick
Published: June 2020

BACKGROUND AND OBJECTIVES:

Rehabilitation after a child’s traumatic brain injury (TBI) occurs in hospital, community, and school settings, requiring coordination of care and advocacy by parents. Our objective was to explore Hispanic parents’ experiences during child’s transitions of care after TBI.

METHODS:

We conducted this qualitative study using semistructured interviews. We used a convenient sample of Hispanic parents of children hospitalized for a TBI in a single level I trauma center. Thematic content analysis using iterative deductive coding and triangulation with clinical data was conducted to identify barriers and facilitators for transitions of care.

RESULTS:

Fifteen mothers, mostly from rural areas and with limited English proficiency, participated in the study. Obtaining outpatient rehabilitation was difficult. Barriers included lack of therapists and clinical providers close to home, worsened by insufficient transportation and other support resources; poor understanding of child’s illness and treatments; and suboptimal communication with clinicians and school administrators. Facilitators included interpreter use, availability of Spanish written information, and receipt of inpatient rehabilitation. Parents of patients discharged to inpatient rehabilitation reported that observing therapies, receiving school discharge plans by hospital-teachers, and coordination of care were facilitators to access outpatient treatments and to support school return. Parents of children discharged from the hospital from acute care reported need of legal services to obtain school services.

CONCLUSIONS:

Hispanic parents, especially those with limited English proficiency, can face significant challenges accessing TBI outpatient rehabilitation and school resources for their children. Although barriers are multifactorial, efforts to improve communication, parent’s TBI education, and care coordination during transitions of care may facilitate a child’s reintegration to the community and school.
Abdominal Wall Defects
Authors: Slater Bethany J. , Pimpalwar Ashwin
Published: June 2020

The 2 most common congenital abdominal wall defects are gastroschisis and omphalocele. Both are usually diagnosed prenatally with fetal ultrasonography, and affected patients are treated at a center with access to high-risk obstetric services, neonatology, and pediatric surgery. The main distinguishing features between the 2 are that gastroschisis has no sac and the defect is to the right of the umbilicus, whereas an omphalocele typically has a sac and the defect is at the umbilicus. In addition, patients with an omphalocele have a high prevalence of associated anomalies, whereas those with gastroschisis have a higher likelihood of abnormalities related to the gastrointestinal tract, with the most common being intestinal atresia. As such, the prognosis in patients with omphalocele is primarily affected by the severity and number of other anomalies and the prognosis for gastroschisis is correlated with the amount and function of the bowel. Because of these distinctions, these defects have different management strategies and outcomes. The goal of surgical treatment for both conditions consists of reduction of the abdominal viscera and closure of the abdominal wall defect; primary closure or a variety of staged approaches can be used without injury to the intra-abdominal contents through direct injury or increased intra-abdominal pressure, or abdominal compartment syndrome. Overall, the long-term outcome is generally good. The ability to stratify patients, particularly those with gastroschisis, based on risk factors for higher morbidity would potentially improve counseling and outcomes.
Dilated Cardiomyopathy Risk in Patients with Coronavirus Disease 2019: How to Identify and Characterise it Early?
Authors: Komiyama Maki , Hasegawa Koji , Matsumori Akira
Published: June 2020

Multiple lines of evidence have shown that elevated blood troponin is strongly associated with poor prognosis in patients with the novel coronavirus disease 2019 (COVID-19). Possible mechanisms of myocardial injury in COVID-19 include ischaemia due to circulatory and respiratory failure, epicardial or intramyocardial small coronary artery thrombotic obstruction due to increased coagulability, and myocarditis caused by systemic inflammation or direct binding of the virus to its receptor, angiotensin-converting enzyme-2 (ACE2), which is abundantly expressed in the heart. It is postulated that persistent immune activation upon viral infection increases the risk of developing dilated cardiomyopathy in COVID-19 patients.
Diagnostic Angiograms and Percutaneous Coronary Interventions in Pregnancy
Authors: Khaing Phyo Htet , Buchanan Gill Louise , Kunadian Vijay
Published: June 2020

Cardiovascular disease is the leading indirect cause of maternal mortality in the UK. Pregnancy increases the risk of acute MI (AMI) by three- to fourfold secondary to the profound physiological changes that place an extra burden on the cardiovascular system. AMI is not always recognised in pregnancy and there is concern among both clinicians and patients regarding catheter-based interventions due to fears of foetal irradiation and risks to the foetus. This article evaluates the current state of knowledge on AMI in pregnancy with particular emphasis on pregnancy-associated spontaneous coronary artery dissection and percutaneous coronary intervention as the revascularisation procedure for AMI. Special considerations that must be made in patients requiring percutaneous coronary intervention for pregnancy-associated spontaneous coronary artery dissection and the current recommendations on arterial access, methods of minimising radiation and stent selection are discussed.
Potential Use of Cellular Stromal Vascular Fraction In Post-COVID-19 Pulmonary Injury and Adult Respiratory Distress Syndrome
Authors: Alexander Robert W.
Published: June 2020

A coronavirus (nCoV-2) has caused a worldwide pandemic, beginning in Wuhan, China. Patient’s acquiring viral infection (COVID-19) which is often featured by elevation of temperature (>100.3 F°), cough, severe fatigue, and a variety of symptoms mimicking the flu and pneumonias. This gradually may extend to a progressive and serious respiratory failure with associated ARDS-like status and severe pneumonias with residual scarring of the interstitial areas of the lung alveoli, resulting in acute life-threatening, and permanent compromised gas exchange.  Those that survive with  controlled ventilation (low tidal volumes), medical induced coma, and prone positioning, are often left with reduction in pulmonary function abilities. This paper reviews some pertinent knowledge and advances in understanding of the pulmonary injuries and long-term damage of the COVID-19 patients, and reports a study to ameliorate such damage with use of cSVF for those who successfully recover.

There now exists technology to perform sophisticated analytics (Functional Respiratory Imaging, FRI) developed by Fluidda (Belgium, EU) which provides great detail and information, including the ability to help triage the infected patients early to help assist in prediction of ventilation and ICU needs. In addition, author’s experience with use in Chronic Obstructive Pulmonary Disease (COPD) and Fibrotic Lung Diseases, the ability to evaluate effectiveness of use of cellular Stromal Vascular Fraction (cSVF) following intravascular deployment of isolated and concentrated cSVF. The hypothesis is that reduction of the widespread pulmonary inflammatory and immune responses which destroy much of the gas exchange abilities in the acute and residual damage which appears to create a long-term problem in the surviving patient population. Fluidda imaging analytics, coupled with standard pulmonary function studies, are effective at predictive studies which may prove of great help in anticipating which patient group is at most risk in the earlier infections to require ICU and potential ventilation needs.

Use of Stromal Vascular Fraction Cells (cSVF) are known to help mitigate damage from severe inflammatory disorders, provide immunomodulation, and promote repair and regenerative effects.  The ease of access, simple ability to obtain significant numbers of viable cell elements, and the deployment via intravascular route has proven safe and efficacious in other forms of lung disease, including fibrotic lung disorders.

This paper reviews many of the current issues facing the severely infected Post-COVID-19 patient’s lung compromise, and a therapeutic option which clearly shows promise to reverse some residual damage of the lung and gas exchange functions.
YouTube celebrity endorsement: audience evaluation of source attributes and response to sponsored content. A case study of influencer Verdeliss
Authors: Monge-Benito Sergio , Elorriaga-Illera Angeriñe , Olabarri-Fernández Elena
Published: June 2020

This article analyses follower response to the growing number of product endorsements present in YouTube videos published under the username “Verdeliss” by Estefanía Unzu Ripoll, Spain’s most popular YouTube influencer on the topic of maternity and childcare. Results of a self-administered online survey of 949 Verdeliss followers focused on their individual evaluations of source attributes indicate that Unzu Ripoll’s YouTube fans tend to buy products she endorses on the basis of her perceived likeability and expertise, and that the overall influence she exerts on their purchasing decisions is slight. In closing, the authors offer insights into how social media influencers can enhance the effectiveness of their online endorsements and identify tactics brands can employ to ensure that the influencers they collaborate with are optimally suited to promote their products.
El ensayo en el audiovisual español contemporáneo: definición, producción y tendencias
Authors: Mínguez Norberto , Manzano-Espinosa Cristina
Published: June 2020

Esta investigación estudia el ensayo audiovisual español mediante una muestra de 200 títulos. Partimos de la consideración del ensayo como un medio de expresión y generación de pensamiento cuyas características reflejan perfectamente la fluidez de la condición contemporánea. Se ha creado una herramienta de estudio con un triple objetivo: identificar un corpus de autores y obras representativos de la producción ensayística audiovisual española, determinar y clasificar las distintas tendencias ensayísticas en función de sus opciones formales y temáticas y contribuir a la definición de las características del ensayo audiovisual. Los resultados aportan datos cuantitativos y cualitativos que revelan una producción atomizada, muy autoral, con predominio de trabajos de corta y media duración y con una amplia diversidad temática y formal. El ensayo se revela como una forma de escritura audiovisual capaz de articular una línea de pensamiento y que posee algunos de los siguientes rasgos: es autorreflexivo y asistemático; presenta una tendencia hacia la subjetividad, pero también se posiciona sobre asuntos de interés público; se aleja de las formas más convencionales del audiovisual y entabla con el espectador una relación intelectual y emocionalmente activa. Se evidencia la dimensión política, social y estética del ensayo, así como su tendencia hacia formas documentales y experimentales.
The image of Barcelona in Online Travel Reviews during 2017 Catalan independence process
Authors: Lozano-Monterrubio Natàlia , Huertas Assumpció
Published: June 2020

Since the emergence of Online Travel Reviews (OTRs), the collective co-creation of a destination brand image has been more evident than ever before. Stories and emotions expressed in these platforms by experienced tourists can significantly influence other users’ intention to visit. This study explores the extent to which political matters like the incidents that occurred during the last quarter of 2017 related with the Catalan independence process may have a negative impact on the brand image of a destination. This paper has used a specific methodology for content analysis of social media in the field of tourism to study the worst rated OTRs (one-star) of seven different attractions of Barcelona in three social media platforms that are able to geolocate places (TripAdvisor, Google Maps and Facebook) to determine the nature, discourses and the emotions raised. Although most complaints refer to the intrinsic problems of the attractions like high entrance prices and long queues due to tourism overcrowding, results reveal that OTR platforms also include tourists’ personal opinions on such issues as politics and religion. The originality of this research paper is that it delves into users’ co-creation of destination brand image through the analysis of negative OTRs and the emotions expressed in their comments.
El interés de la audiencia española en la política televisada: de los debates electorales al "politainment"
Authors: Quintas-Froufe Natalia , González-Neira Ana , Conde-Vázquez Erika
Published: June 2020

La política televisada se ha convertido en un eje imprescindible en la planificación de las campañas electorales de cualquier partido político. La televisión es la principal fuente de información durante los procesos electorales y los espacios de politainment se han erigido en citas decisivas para los candidatos. Este artículo realiza un análisis diacrónico de la evolución de las audiencias de los debates televisados en España para comprobar si el paso del tiempo ha erosionado este formato. La muestra está formada por los diez debates electorales entre los aspirantes a presidir el Gobierno de España celebrados hasta abril de 2019. Asimismo, presta atención a la integración de otras pantallas en la difusión y visionado del debate electoral como Twitter. Los resultados de dicha investigación demuestran el interés de la audiencia española por este formato desde su primera emisión en 1993 hasta la actualidad, convirtiéndolos en verdaderos hitos televisivos. Además, los candidatos también han incrementado su presencia en la televisión a través de otros formatos de entretenimiento con el fin de mostrar otras facetas más humanas y emocionales al electorado. Esta reciente exposición mediática de los líderes políticos también ha sido seguida por la ciudadanía española.
Detection of Luminescence Centers in Colloidal Cd\(_{0.3}\)Zn\(_{0.7}\)S Nanocrystals by Synchronous Luminescence Spectroscopy
Authors: Thang Phi Van , Tuyen Ho Van , Quang Vu Xuan , Lieu Nguyen Thi Thuy , Thanh Nguyen Trong , Nghia Nguyen Xuan
Published: June 2020

With the advantages of selectivity, spectral resolution and reduction of interference on account of light scattering, synchronous luminescence spectroscopy (SLS) is successfully applied to analyze complex mixtures with overlapped emission and/or excitation spectra. In fact, it is difficult to clearly distinguish the contributions of various luminescence centers to low-energy band of semiconductor nanocrystals (NCs). Herein, we report the application of SLS method to detect luminescence centers in colloidal Cd0.3Zn0.7S NCs. Their conventional luminescence and synchronous luminescence spectra were comparatively investigated. Differently from conventional luminescence spectrum, the emission peaks at 460 and 515 nm were found using SLS method. They are attributed to the emission transitions related to sulfur and zinc/cadmium vacancies. The obtained results are useful to clarify the nature of luminescence centers as well as relaxation mechanism in CdxZn1-xS NCs.
Neurobiological and Relational Bases for Understanding Aggressiveness
Authors: Poljak Lukek Saša , Valenta Tanja
Published: June 2020

Aggression is a deliberate, proactive or impulsive, defensive or active act, expressed through the use of physical power or psychological pressure. As such, it is a significant element of violent behaviour. According to developmental stages, aggression is expressed in various forms and is associated with the specific ways of regulating the feelings of shame and anger. We assume that excessive exposure and interrupted contact in development can lead to a specific regulation of the affects of shame and anger in a person who, because he feels threatened, can transform these feelings into aggressive behaviour. In addition, the dysregulated affects can lead to the dissociation of emotional experience, and thus to the inability to feel empathy, which allows for deliberate or proactive aggressiveness. Furthermore, the text presents the basic conclusions of research in the neurobiological understanding of aggression. The aggressive action is characterized by the specific functioning of the prefrontal cortex, the amygdala, and the sympathetic and parasympathetic nervous system. Abuse in childhood and relational trauma are presented as a starting point for the specific functioning of the brain and specific affect regulation, which can also be associated with aggressive behaviour in adulthood.
When the Family becomes the Most Dangerous Place: Relations, Roles and Dynamics within Incestuous Families
Authors: Repič Slavič Tanja
Published: June 2020

The family is supposed to give the child a sense of security, belonging, acceptance and love.1 If, however, instead of these pleasant experiences, the most prevalent atmosphere is that of, abuse, trauma, violence, horror and fear, the child will not feel safe, accepted and loved. Even worse, later in life, he will unconsciously search for situations that will awaken in him, and re-create that primary atmosphere and underlying affects, because in his intrapsychic world, they equal belonging and familiarity. Clinical experience and research show that incest is one of the severest traumas caused to the human psyche and body. In the paper, we will first present the definition, prevalence and discuss factors such as the duration of the incest and the age of victims and perpetrators. Then, we will describe the relations, roles and dynamics within incestuous families, where the child finds himself with his own pain among people who should be trustworthy, who should give safety and a sense of being loved, but instead they abuse the child, violating all the boundaries, taking away one’s dignity and killing the soul.
New Phenomena in the Sphere of Derivation Formants as Reflection of the Dynamics of the Russian Language Word-Formation System
Authors: Nikolina Natalia , Ratsiburskaya Larisa , Fatkhutdinova Venera
Published: June 2020

The article considers both new functional characteristics of known word-forming formants and new derivational formants. In modern Russian speech, there has been discovered such a new phenomenon, as the mobility of borrowed elements which can be qualified as affixes (ап, аут, ин, овер). Well-known formants of Greek and Latin origin have proved to perform new pragmatic-stylistic functions: prefixoids нано-, кибер-, крипто-; suffix -оид. These formants are mostly characteristic of terms, but, as the study showed, they can participate in the creation of expressive derivatives. The article uses the material of neologisms in fiction and media texts to identify new formants: prefixes мега-, нон-, он-, оф-; suffixes -инг, -раст; suffixoids -гейт, -оголик; movable formants ап, аут, ин, овер. The appearance of new formants and new semantic and pragmatic characteristics of the known formants reflects the dynamics of the word-formation system of the Russian language, due to the processes of internationalization, "ameroglobalization" in different languages at the turn of the 20 th – 21 th centuries. Neo-derivatives testify to the specifics of knowledge and experience acquisition with the help of word-formation methods and means relevant for a certain period of time. The results of the study contribute to derivatology, neology, pragmalinguistics and can be useful for lecturers and students of higher educational institutions majoring in "Philology" and "Journalism".
Homographic Proper Names: On Peculiarities of Pronunciation Registration
Authors: Ivanova Natalya , Kuzmina Rimma
Published: June 2020

The article considers phonetic variants of English proper names that comprise homographic groups, and some impairments during their registration in pronouncing dictionaries. The authors present the results of lexicographic and comparative analysis of units extracted from two pronouncing dictionaries: "Cambridge English Pronouncing Dictionary" by D. Jones and "Longman Pronunciation Dictionary" by J. Wells using the continuous sampling method. Particular attention is focused on the methods of registration and completeness of phonetic notation of homographs pronunciation. A number of peculiarities are noted in recording semantics, phonetic-and-orthographic variations in some homogroups in British and American English. Clear inconsistency and insufficiency of lexicographic parametrization of both homographic proper names and their national and social pronunciation variants, as well as the meanings of common and proper names are revealed. The conclusion is made about the accuracy of "Cambridge English Pronouncing Dictionary" in terms of registering several British and American variants of onyms pronunciation, supplemented by additional comments on the phonetic variants and meanings of numerous types of proper names (anthroponyms, toponyms, ergonyms). The data obtained are required for differentiating the meanings of proper names, correct use of onyms and appellatives in oral speech, as well as for compiling dictionaries and reference books.
Seizures in patients with respiratory disease - a retrospective single center study
Authors: AYDIN Senay , ÖZDEMIR Cengiz , GÜNDÜZ Ayşegül , KIZILTAN Meral E.
Published: June 2020

ABSTRACT Objective: Seizures are a neurological condition commonly experienced during the follow-up period after systemic or metabolic disorders. The aim of the present study was to determine the etiological factors of seizures in patients at a tertiary care chest clinic. Methods: We reviewed all neurology consultations that were requested due to seizures in inpatient clinics in a tertiary care hospital specializing in respiratory disorders between January 2011 and January 2018 were retrospectively reviewed. Results: The present study included 705 of 2793 (25.2%) patients who requested consultations for seizures during the study period. The mean age of the sample was 64.05±17.19 years. Of the 705 patients, 307 (43.5%) had a previous history of epilepsy (Group I) and 398 (56.5%) had a first-time seizure and were considered to have symptomatic seizures (Group II). Multiple factors played roles in the development of seizures in 54.8% of the patients. In most patients, metabolic causes, systemic infections, and drug use were identified and an intracranial metastatic mass lesion was the major cause in patients with lung cancer. Rates of hypoxemia and respiratory acidosis were significantly higher in patients with symptomatic seizures (Group II) than in patients with primary epilepsy (Group I). Conclusions: Blood gas changes such as hypoxemia and respiratory acidosis were among the factors statistically associated with the development of symptomatic seizures in patients with respiratory diseases. Additionally, hypoxemia, hypercapnia, and respiratory acidosis were correlated with mortality in patients hospitalized for respiratory system diseases who requested consultations for seizures.
Hardy-Weinberg Equilibrium in different mitochondrial haplogroups of four genes associated with neuroprotection and neurodegeneration
Authors: MEHRPOUR Sheida , RODRIGUES Camila Ronqui , FERREIRA Renata Carmona , BRIONES Marcelo Ribeiro da Silva , OLIVEIRA Acary Souza Bulle
Published: June 2020

ABSTRACT Background: Malfunctioning or damaged mitochondria result in altered energy metabolism, redox equilibrium, and cellular dynamics and is a central point in the pathogenesis of neurological disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis. Therefore, it is of utmost importance to identify mitochondrial genetic susceptibility markers for neurodegenerative diseases. Potential markers include the respiratory chain enzymes Riboflavin kinase (RFK), Flavin adenine dinucleotide synthetase (FAD), Succinate dehydrogenase B subunit (SDHB), and Cytochrome C1 (CYC1). These enzymes are associated with neuroprotection and neurodegeneration. Objective: To test if variants in genes RFK, FAD, SDHB and CYC1 deviate from Hardy-Weinberg Equilibrium (HWE) in different human mitochondrial haplogroups. Methods: Sequence variants in genes RFK, FAD, SDHB and CYC1 of 2,504 non-affected individuals of the 1,000 genomes project were used for mitochondrial haplogroup assessment and HWE calculations in different mitochondrial haplogroups. Results: We show that RFK variants deviate from HWE in haplogroups G, H, L, V and W, variants of FAD in haplogroups B, J, L, U, and C, variants of SDHB in relation to the C, W, and A and CYC1 variants in B, L, U, D, and T. HWE deviation indicates action of selective pressures and genetic drift. Conclusions: HWE deviation of particular variants in relation to global populational HWE, could be, at least in part, associated with the differential susceptibility of specific populations and ethnicities to neurodegenerative diseases. Our data might contribute to the epidemiology and diagnostic/prognostic methods for neurodegenerative diseases.
Cerebral amyloid angiopathy: a cross-sectional study in a single center in Northeastern Brazil
Authors: BARROS-ARAÚJO Marx Lima de , RICARTE Irapuá Ferreira , MONTALVERNE FILHO Edward , HOLANDA Guilherme Marconi Guimarães Martins , SOUSA Ícaro Araújo de , CORRÊA Matheus Rodrigues , NOGUEIRA Matheus Rocha de Seixas , CRONEMBERGER Pedro Jorge Luz Alves
Published: June 2020

ABSTRACT Background: Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder caused by progressive deposition of β-amyloid peptides in the walls of small and medium-sized cortical and leptomeningeal vessels. Until today, the prevalence of CAA is unknown in our region. Objective: This study aims to analyze the prevalence of this entity in a specific elderly population in a tertiary hospital in Northeastern Brazil. Methods: A cross-sectional, retrospective study with the enrollment of patients aged 65 or older followed in the neurological outpatient service of the Universidade Federal do Piauí, Brazil, who underwent brain magnetic resonance imaging (MRI) from July 2016 to June 2018. Results: One hundred and seventy-four patients were enrolled, of whom 100 were women (57.4%) and 74, men (42.6%), aged from 65 to 91 years old (median age 73.27). Nine patients were excluded from the study due to unavailability of MRI sequences needed for an appropriate analysis. Out of the 165 remaining patients, 12 (7.2%) had established the diagnosis of CAA, according to the modified Boston criteria. Conclusion: The prevalence of CAA in our study was like those of medical literature, with a progressive age-related increase.
“Kierkegaard Não SE Desprendeu De Hegel”: Notas Sobre O Juízo De Heidegger Sobre Kierkegaard Em A Hermenêutica Da Facticidade
Authors: Silva Gabriel Ferreira da
Published: June 2020

Resumo O curso proferido por Heidegger, no semestre de verão de 1923, e publicado posteriormente, sob o título de Ontologia: a hermenêutica da facticidade, é um dos importantes loci nos quais Heidegger deixa entrever tanto a influência e importância de Kierkegaard quanto algumas de suas avaliações acerca do pensamento do filósofo dinamarquês. Uma delas, em especial, não obstante formule um interessante juízo sobre a relação entre Kierkegaard e Hegel - a partir da figura de F. A. Trendelenburg -, um dos temas mais revisitados da literatura interpretativa sobre Kierkegaard, não tem sido objeto frequente de avaliação por aqueles intérpretes. Assim, o objetivo deste artigo é expor, analisar e avaliar as teses de Heidegger sobre a relação Kierkegaard-Hegel, a fim de sopesá-las em sua correção. Por fim, o artigo apresenta algumas reflexões metafilosóficas, avaliando o juízo de Heidegger sobre Kierkegaard, quanto a não ter se “desprendido de Hegel”.
Conquistar o Tertium Datur: Sloterdijk Em defesa de uma “antropologia cibernética” (entre Heidegger, Günther e Latour)
Authors: Pitta Maurício Fernando , Weber José Fernandes
Published: June 2020

Resumo: Martin Heidegger desenvolveu uma análise da metafísica e da tecnologia que questionava radicalmente seus pressupostos ontológicos. Contudo, para Peter Sloterdijk, autor de uma revisão do motivo da clareira (Lichtung) heideggeriana intitulada Domesticação do ser: clarificando a clareira, Heidegger padece daquilo mesmo que ele critica: uma pendência para a ontologia clássica que, desde pelo menos Platão e Aristóteles, separa o ser e o nada, basila o princípio de bivalência na lógica, excluindo qualquer terceira possibilidade, e permite os dualismos constitutivos da metafísica. Seguindo o antropólogo Bruno Latour, o qual evidenciara que “modernidade” não é senão uma crença na cisão entre os polos de forma e matéria, sujeito e objeto, natureza e cultura, também Sloterdijk vai atribuir a Heidegger a pendência à ontologia clássica, elevada ao nível da cisão entre o ôntico e o ontológico. Diante disso, o que sugere Sloterdijk? Uma alternativa à ontologia clássica na cibernética de Wiener e Günther, reatando os laços, desfeitos por Heidegger, entre ontologia e antropologia. Este trabalho tem por intenção articular a crítica de Sloterdijk, a investigação de Latour e a revisão ontológicológica de Günther, a fim de assentar bases para compreensão do projeto sloterdijkiano de se pensar a antropologia a partir de pressupostos cibernéticos.
Intervenção para a implementação do monitoramento clínico em serviços especializados de atenção às pessoas vivendo com HIV/aids
Authors: Loch Ana Paula , Caraciolo Joselita Maria de Magalhães , Rocha Simone Queiroz , Fonsi Mylva , Souza Rosa de Alencar , Gianna Maria Clara , Gonçalves Alexandre , Kalichman Artur Olhovetchi
Published: June 2020

O monitoramento clínico de pessoas vivendo com HIV/aids (PVHA) contribui para a identificação e gestão de caso das pessoas sem início de tratamento (gap), em falha terapêutica e em abandono de tratamento. O objetivo deste artigo é apresentar e discutir o desenvolvimento de uma metodologia para a implementação do monitoramento clínico das PVHA em serviços do Sistema Único de Saúde (SUS). A metodologia utilizada desde 2014 pelo Centro de Referência e Treinamento DST/AIDS-SP-Coordenação do Programa Estadual de IST/AIDS do Estado de São Paulo, Brasil, foi reestruturada em três reuniões, no período de junho a agosto de 2018. Foram mantidos os eixos de apresentação do número de usuários com falha terapêutica, em gap e em abandono de tratamento nos serviços participantes, e a discussão de vulnerabilidades individuais, sociais e programáticas. Foi adicionado um novo eixo que direciona a discussão das possibilidades de reorganização de fluxos assistenciais e práticas gerenciais do serviço. Adicionalmente, a intervenção passou a ser feita nos serviços de saúde, com a participação de um número maior de profissionais da equipe multiprofissional, discussão de casos, fluxos e processos de trabalho e encontros regionais para a troca de experiências em monitoramento clínico entre os serviços. A reestruturação da metodologia contribuiu para a diminuição do gap de tratamento, reorganização de fluxos assistenciais e inclusão do monitoramento clínico como ferramenta de gestão nos serviços de assistência especializada às PVHA. Essa metodologia pode ser implementada por outros programas estaduais, municípios e serviços, uma vez que todos têm acesso às mesmas fontes de informação usadas nesta intervenção.