bluuebunny/crossref_metadata_2025 huggingface dataset:
Teaching Case: Read to Win: Using the Game-based System Design Framework to Gamify a Summer Reading Program
Authors:   University of Arkansas at Little Rock, Barber Connie , Wang Wenjun ,   University of Arkansas at Little Rock
Published: February 2024

The use of gamification for organizational initiatives, such as increased foot traffic and customer engagement, is on the rise. Given this, recent information systems graduates may find themselves on project teams aimed at making decisions about gamification efforts. Currently, information systems curriculum doesn’t typically address the use of specific frameworks to design and document requirements for a game-based information system to meet a business need. This teaching case exposes students to the use of the Game-based System Design Framework in combination with the Game-based System Design Diagram to enhance student learning around the design and documentation of a gamified information system. This case could be used in an undergraduate or graduate program in either a systems analysis and design or a capstone course. The use of this case assumes that students have a basic understanding of business requirements gathering and project scope statements. Additionally, in order to develop a solution to this case, it must be used in conjunction with the article “All Work and All Play? A Framework to Design Game-based Information Systems” (Barber et al., 2021).
Concepts of psychological well-being in three waves of cognitive-behavioral therapy
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, ABRAMOV Volodymyr
Published: February 2024

This article analyzes the concepts of psychological well-being and the mechanisms of its achievement in three waves of cognitive-behavioral therapy (CBT): the behavioral therapy of the first wave, the classical cognitive therapy of A. Ellis and A. Beck of the second wave, and the contextual therapies of the third wave. The ideal of psychological well-being in classical behavioral therapy involves an individual's frustration tolerance, enabling a change in their response to uncomfortable stimuli. Primary methods to achieve this ideal include step-by-step desensitization and the development of alternative behaviors through operant conditioning. Classical cognitive therapy by A. Ellis and A. Beck operates with a more comprehensive model, considering personal factors influencing reactions to stimuli. This has led to the development of correction techniques for erroneous thinking strategies, viewed as distortions in objective information processing. Consequently, the ideal of psychological well-being is seen as a more realistic perception of reality, achieved through correcting cognitive constructs such as automatic thoughts and core beliefs aligning them with reality through testing, such as behavioral experiments. According to proponents of the second wave, individuals should adopt a scientist's mindset by formulating and testing hypotheses. In the third wave of CBT, the ideal of psychological well-being involves individuals adopting a detached observer position toward events in their inner world, including thoughts, emotions, and core beliefs. Additionally, great importance is placed on individuals pursuing their own values. The mechanism for achieving this ideal involves changing the context of distress-inducing thoughts without altering their content. Despite some contradictions between the views of the second and third waves of CBT, the techniques of these approaches are consistent and can be used sequentially. Corrections in thought processes, as facilitated by second-wave therapy, can change the status of thoughts from being perceived as objective truths, which can be further deepened through third-wave techniques, altering the status of thoughts from objects to contextual elements in an individual's life.
The Influence of time perspective and personality traits on the psychological well-being of Ukrainian refugees in Europe
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, KELLER Vladyslava
Published: February 2024

Background. The Russian invasion of Ukraine in 2022 led to a sharp increase in the number of Ukrainian refugees in Europe. Due to the war and the subsequent need to adapt to new socio-cultural conditions, the mental health of this population is particularly vulnerable. People who have been forced to leave their country experience significant stress and are prone to developing symptoms of anxiety and depression. While psychopathology in this context has been well researched, protective factors that could potentially contribute to a better adjustment of Ukrainian refugees in the new environment have been less frequently studied. Accordingly, this study aims to fill this gap by examining the role of time perspective and personality traits in influencing the psychological well-being of Ukrainian refugees. Methods. A sample of 599 Ukrainian refugees from different European countries was studied using three key instruments: the Zimbardo Time Perspective Inventory, short version (ZTPI-15), the Big Five Personality Inventory, short version (BFI-10), and the Singer-Wheeler Life Satisfaction Scale (SWLS). Correlation and hierarchical regression analyses were used to determine the relationships between these constructs. Results. Both time perspective and personality traits were shown to predict subjective well-being significantly. In particular, refugees who demonstrate greater openness, emotional stability, and friendliness report higher levels of life satisfaction. Similarly, positive orientations toward the past and future were associated with increased well-being, while negative orientations were associated with decreased well-being. In contrast, conscientiousness, extraversion, and fatalistic orientation to the present were not significant predictors of subjective well-being, which is at odds with some existing literature. Conclusions. These findings emphasize the importance of considering both time perspective and personality traits in understanding the psychological well-being of Ukrainian refugees. They also point to the potential benefits of interventions to develop adaptive time perspectives and positive personality traits. Further research is needed to develop and evaluate such interventions.
Pathogenetic mechanisms of comorbid anxiety disorders in persons with social anxiety disorder: the role of dysfunction cognitive schemes
Authors:   Ukrainian Catholic University, Lviv, Ukraine, AVRAMCHUK Oleksandr
Published: February 2024

Background. Anxiety disorders are one of the common categories of mental health problems characterized by a persistent debilitating feeling of anxiety, which is due mainly to unproductive expectations about potential challenges or threats. For example, for people with social anxiety disorder, the fear of social situations can feel so intense that it seems out of their control, leading to a tendency toward social isolation and complicating the recovery process. Methods. An empirical study was conducted between 2018 and 2022 among individuals (aged 18-40) with social anxiety disorder and with clinically significant symptoms of co-occurring anxiety disorders (including generalized anxiety disorder and symptoms of panic attacks) according to DSM-5 criteria - the main the group consisted of 651 people. All study participants participated voluntarily and provided informed consent. Results. Individuals with social anxiety disorder exhibit higher levels of clinical anxiety and general distress compared to controls. Significant differences in the intensity of early dysfunctional schemes were also found compared to the control group. Correlations between manifestations of dysfunctional schemas, levels of social anxiety and manifestations of comorbid psychopathology have been demonstrated. It has been suggested that the contribution of cognitive, emotional, and behavioral responses related to schemas such as social isolation/alienation, incompetence/failure anticipation, and catastrophe anticipation may explain the distribution of variability in social anxiety symptoms and comorbid anxiety symptoms. Conclusions. The analysis of the results of the empirical study confirms the close relationship between dysfunctional beliefs and the severity of anxiety psychopathology in individuals with social anxiety disorder. Considering the features of the functioning of deep beliefs about oneself and social interaction, structured into cognitive schemes, can contribute to a practical approach to therapy and improve the quality of life of persons with the specified symptoms. Further research can be directed at expanding the role of early dysfunctional schemes in the pathogenesis of comorbid conditions and the role of avoidance mechanisms in adapting to life circumstances.
Psychometric properties of the Ukrainian version of the vocational identity status assessment (VISA-19)
Authors:   V. N. Karazin Kharkiv National University, Kharkiv, Ukraine, AKKAYA Kateryna , Olefir Valeriy ,   V. N. Karazin Kharkiv National University, Kharkiv, Ukraine
Published: February 2024

Background. Vocational identity is considered one of the most important domains of overall identity, and its study is gaining increasing relevance and popularity among Ukrainian researchers. An especially crucial aspect of the research on vocational identity is the study of its development. However, we have identified a lack of Ukrainian methods for researching vocational identity development. This study is dedicated to translating and adapting the English-language Vocational Identity Status Assessment (VISA) questionnaire and examining its psychometric properties and measurement invariance for Ukrainian students. Methods. In a cross-sectional study, 458 students from various specialties in their 1st to 5th years participated (62% were female), aged 17 to 22 years (M = 19). The North American Vocational Identity Status Assessment (VISA) questionnaire, developed by Porfeli et al. (2011), was used for translation. Two translators performed both forward and backward translations, and the translated version was presented to the participants via Google Forms. A confirmatory factor analysis was conducted to assess the questionnaire's factor structure, validity, reliability, and measurement invariance. Results. The shortened version of the questionnaire (VISA-19) was accepted as the primary version, demonstrating the six-factor original structure and good psychometric properties: CFI = 0,954, TLI = 0,943, RMSEA = 0.067[0,060-0,075], SRMR = 0,053, a ranges from 0,69 to 0,81, CR from 0,65 to 0,77, AVE from 0,43 to 0,59, HTMT from 0,057 to 0,856. Metric, scalar, and strict measurement invariance by gender for the shortened version of the questionnaire was established, with ACFI ranging from -0,004 to 0,000, ARMSEA from -0,001 to 0,003, and ASRMR from 0,001 to 0,005. Conclusions. The Ukrainian shortened version of the VISA-19 questionnaire exhibited good psychometric properties and measurement invariance by gender and can be utilized for further research and practical applications.
Karakteristik ikan tandipang (Dussumeiria acuta) asap
Authors: Rakhmayeni Dyah Ayu , Yuniarti Tatty , Sukarno Sukarno , Prayudi Adham
Published: February 2024

Pengasapan merupakan perpaduan teknik pengeringan serta penambahan senyawa kimia hasil pembakaran kayu guna mempertahankan daya awet ikan. Tujuan penelitian ini adalah menentukan profil kimia dan keamanan pangan ikan tandipang asap dengan perbedaan konsentrasi dan lama perendaman asap cair. Metode yang digunakan adalah eksperimental dengan rancangan percobaan yang digunakan yakni rancangan acak kelompok faktorial (RAK) dengan 3 kali ulangan. Variabel yang diamati adalah konsentrasi asap cair (1, 3, dan 5%)  dan lama perendaman (15, 30, 45, dan 60 menit). Parameter yang diuji yaitu proksimat, fenol, formaldehida, PAHs dan TPC. Hasil proksimat ikan tandipang asap cair menunjukkan kadar air 8,61-28,89%; abu 4,37-6,20%; lemak 1,91-6,75%; dan protein 62,21-81,56%. Perlakuan terpilih berdasarkan hasil uji hedonik (kesukaan) dengan nilai tertinggi pada atribut rasa untuk ikan asap dengan perlakuan konsentrasi asap cair 3% dan lama perendaman 45 menit dengan nilai 7,2. Profil kimia ikan tandipang asap terpilih yaitu pada perlakuan konsentrasi asap cair 3% dengan lama waktu perendaman selama 45 menit memiliki kadar air 23,77%; abu 5,64%; lemak 4,99%; protein 76,33; fenol 0,356 %; PAHs < 0,1 ppb; dan formaldehid < 0,003%.
Deep Learning Estimating of Epicentral Distance for Earthquake Early Warning Systems
Authors: Noda Shunta
Published: February 2024

To enhance the performance of earthquake early warning (EEW) systems that aim to issue alerts as quickly as possible, it is crucial to improve the accuracy of the epicentral distance Δ estimated via the single-station method. Although the conventional method estimates Δ from the slope of the initial P-wave envelope, this study applies deep learning techniques that can extract a variety of information from the waveform data. By analyzing ∼20,000 records observed at Kyoshin Network stations in Japan, the convolutional neural network (CNN) method achieved higher accuracy than the conventional method. Increasing the data length or the number of iterations of convolution, activation, and pooling layers in the typical CNN model did not significantly improve the accuracy of Δ estimation. An automatic structure search (AutoSS) technique, in which model structure and hyperparameters are randomly varied, was employed to identify models that yield higher accuracy. A typical CNN model was used as the initial structure. The models obtained through this technique showed improved accuracy with increased data length or computational cost. The models that delivered the highest accuracy among those generated using the AutoSS technique outperformed the typical CNN model in terms of accuracy, although their computational costs were comparable. The AutoSS technique offers a significant advantage in that it allows the selection of a model that matches the computational capabilities of the hardware used for its implementation, thereby ensuring optimal computational efficiency. This exhibits that deep learning technologies can be used to improve the performance of EEW systems.
Aplicação de uma ferramenta de apoio à tomada de decisões no processo de projeto de uma casa passiva para o semiárido
Authors: Baggio Gabriela Do Rosário , Leite Renata Do Prado , Hansen Rafael Lucas Escobar , Meireles Eduado Andrey Silva , Verussa Giovanna Schiwinski , Dias Kimberly Gabriela Angelo , Sorgato Marcio Jose , Fernandes Leandro Carlos
Published: February 2024

A segunda metade do século XX foi marcada pelo afloramento da consciência ambiental na sociedade. Na arquitetura, surgiram diversas vertentes, abordagens e ferramentas para apoiar a inserção do viés ambiental nas práticas de projeto. No entanto, no presente, não se conta com abordagens estruturadas passiveis de serem aplicadas a diferentes contextos ambientais. Diante disso, vem sendo desenvolvida uma abordagem para o projeto de edificações focada tanto nas necessidades dos usuários quanto no baixo impacto ambiental. Esta pesquisa teve como objetivo testar a aplicação dessa abordagem no processo de desenvolvimento de um estudo preliminar para uma habitação hipotética para o clima semiárido da cidade de Picos/PI. Para isso, foi utilizada como apoio a ferramenta Antropo, que automatiza a análise de dados e fornece diretrizes para os projetistas. Como resultado, obteve-se um conjunto de diretrizes que foram traduzidas para a forma de uma edificação compacta, com alta capacidade térmica, sombreada, configurada de maneira a possibilitar a ventilação seletiva e a tirar proveito do resfriamento evaporativo. Embora o experimento não conte com uma etapa de testes computacionais, obteve-se um projeto que atende boa parte das principais recomendações apontadas pela bibliografia para o clima em questão.
Estágio Curricular Supervisionado: relato da experiência discente em uma unidade básica de saúde
Authors: Vieira Justino Thaysa Maria , Gonçalves Barbosa Kalliny Mirella , Araújo Ribeiro Fernanda Maria , Fernandes Pereira Emily , Amaral Camelo Calheiros Rillary , Sales Ribeiro Francielma , Sheila Sarmento Sued
Published: February 2024

Objetivo: relatar experiências vivenciadas por estagiárias de enfermagem, da Universidade Federal do Vale do São Francisco, durante as atividades de estágio em uma Unidade Básica de Saúde do município de Petrolina-PE. Trata-se de um estudo descritivo, do tipo relato de experiência, desenvolvido a partir da atuação das estagiárias em um serviço de atenção básica no período de janeiro a abril de 2022. Descrição  da  experiência: As atividades desenvolvidas durante esse período mostraram os desafios que envolvem a rotina do profissional de enfermagem, bem como suas atribuições e responsabilidades com a população adscrita. Destaca-se que a experiência permitiu a aproximação com o Sistema Único de Saúde em um contexto de pandemia, sendo possível identificar as dificuldades enfrentadas na rotina e a necessidade de reinventar o processo de trabalho para garantir assistência de qualidade aos usuários. As atividades desenvolvidas e/ou acompanhadas foram: atendimento aos sintomáticos respiratórios; atendimento às pessoas com arboviroses; notificação de doenças e agravo; vacinação; saúde da mulher e planejamento familiar e reprodutivo; pré-natal; desfecho de gestação; saúde da criança e adolescente; ações voltadas ao rastreio e tratamento de casos de hanseníase; curativos e outros procedimentos; consulta compartilhada; visita domiciliar; territorialização e perfil epidemiológico; e gerenciamento de serviços de saúde. Conclusões: O Estágio Curricular Supervisionado configurou-se como ferramenta importante para o crescimento pessoal e profissional, a partir da aproximação com o cenário de trabalho e vivências que exigiam o raciocínio clínico para a tomada de decisão em enfermagem.
Pearson Correlation and Multiple Correlation Analyses of the Animal Fat S-Parameter
Authors: Ikhwan Muhammad Fikri , Mansor Wahidah , Khan Zuhani Ismail , Adzhar Mahmood Mohd Khairil , Bujang Aisah , Haddadi Kamel
Published: February 2024

In specialised food products, the detection and identification of various sources of oils and fats are essential. Consumers are concerned about the adulteration of vegetable oils to avoid health problems and the risk of developing heart disease. There were a few cases where less expensive animal fat, in particular pork fat, was found in halal meals. The limitations of conventional methods for detecting pork in other meats can be overcome with the use of non-destructive methods. This study reveals the feasibility of using the microwave non-destructive testing method to identify animal fats. In the frequency between 8 GHz and 12 GHz, the microwave non-destructive testing method was used to obtain the S-parameters of the chicken, beef, and pork fats in the form of raw, baked, and oil. Single and multiple correlation analyses were then performed to identify the relationship between the animal fats and to differentiate them. The results of the Pearson correlation analysis show that for all animal fats, both raw and baked fat had a higher correlation value, which indicated they have the same or similar features. The different correlation values obtained from the multiple correlation analysis demonstrated that animal fats have distinct features, regardless of whether they are raw, baked, or liquid forms. The multiple correlation analysis is a more suitable technique to detect animal fats compared to the Pearson correlation analysis.
Web-Based Window Shopping: A Learning Model in High School's Mathematics Curriculum
Authors: Effendi Moh. Mahfud , Putri Rosyadi Alfiani Athma , Fatihah Shofy Maulidya , Purnomo Heri , Abdullah Abdul Halim
Published: February 2024

The post-pandemic adaptation demands technological innovations in sustainable learning to support mathematics curriculums. This research aims to develop the Web-based Window Shopping (WBWS) in high school mathematics curriculum with ADDIE procedure. The data were collected through interviews, questionnaires, and tests. The stages of research comprised analysis, design, development, implementation, and evaluation. The experts' validation test results showed that the aspects of materials and medium achieved an average score of 82,75%. Meanwhile, the trial test results showed that the developed WBWS is worth implementing, with the average percentage of effectiveness reaching 83,33%. The results suggest that the creation of WBWS as a web-based learning model for mathematics curriculum is not only feasible but also meets the educational needs of high school students. Teachers and students can use this web-based learning model as an alternative for implementing the independent curriculum on mathematics learning.
To a Question on Increase of Professional Competence of the Future Teachers in Sphere of Family-pedagogical Cooperation
Authors:   Saratov State University, Khutorian T. V.
Published: February 2024

In article the description special course «Technology of the organisation and realisation of cooperation with a family of the younger schoolboy», approved in teacher training University with a view of increase of professional competence of the future teachers is presented in sphere of family-pedagogical cooperation. The purposes, problems, the maintenance, structure and requirements to level of development of a material of a special course reveal. It is noticed that vocational training of the future teachers to family-pedagogical cooperation provides, finally, development of abilities to carry out cooperation with a family in professional work.
The Analysis of Approaches to Mentality Studying in a Psychological Science
Authors:   Samara State Social and Pedagogical University, Belkin A. I.
Published: February 2024

The analysis of the historical and psychological literature has allowed to reveal a number of approaches to definition of concept «mentalition» and «mentality». Works of the Moscow psychological school represent attempts to consider integrated mechanisms of mentality and its communication with generalising socially-psychological characteristics of the person and share on two directions socially-psychological categories, such as the way of life, social representations, etc. At Petersburg psychological school are understood as mentality historically steady public installations, values and the norms having both realised, and not realised character.
Pedagogical Personnel’s Gender Edication
Authors:   Ulyanovsk State Pedagogical University named after IN Ulyanov, Shustova L. Р.
Published: February 2024

The article says about importance of developing gender approaches in education that can allow us to take into account abilities, possibilities and educational demands of female and male representatives. The role of a modern educational institution in creating gender self awareness of subjects of education is examined. Different forms of gender education of pedagogical trained specialists: teachers of higher educational Institutions, teachers at schools and psychologists and students of teachers’ training colleges are represented.
Methods of Andragogical Support
Authors:   Saratov Institute for Advanced Studies and Retraining of Educators, Pilyugina S. A.
Published: February 2024

Postgraduate pedagogical training is a part of the system of the uninterrupted training. Realization of postgraduate pedagogical training of teachers is possible on the basis of the andragogical support. Methods of andragogical support of an educational activity of a teacher is one of the means of andragogical support of postgraduate pedagogical training.
Prediction of underweight, short stature, and microcephaly based on brain diffusion-weighted imaging sequence in neonates with stage.2 of hypoxic-ischemic encephalopathy: A follow-up study
Authors: Tafti Mohammad Golshan , Jafari Marjan , Mirjalili Seyed Reza , Fallah Razieh , Shamsi Farimah
Published: February 2024

Background: Hypoxic-ischemic encephalopathy (HIE), caused due to reduced oxygenation and brain blood flow, occurs in 1-8 per 1000 live full-term births in developed countries and up to 26 per 1000 live in the developing world. The growth status of survivors of birth HIE has not been evaluated sufficiently.
Objective: This study evaluated, the growth parameters (weight, height, and head circumference) of neonates with Sarnat stage 2 of HIE at 6, 10, and 12 months and its relationship with findings of neonatal brain diffusion-weighted imaging (DWI) sequence.
Materials and Methods: Medical records and growth parameters of 35 neonates with gestational age > 34 wk who were admitted with stage 2 of HIE in Neonatal Intensive Care Unit of Shahid Sadoughi hospital, Yazd, Iran from March 2021-March 2022, and its relationship with neonatal brain DWI sequence finding was evaluated.
Results: 15 girls and 20 boys with a mean birth weight of 2880.3 ± 221.8 gr were evaluated. Conventional magnetic resonance imaging and DWI were found to be abnormal in 6 (17.1%) and 18 neonates (51.4%). The most abnormal finding of DWI was high signal in basal ganglia/thalamus in 9 neonates (25.7%). Abnormal DWI is more frequent in neonates with seizures and low birth weight. Hospital stay days were more prolonged in neonates with abnormal DWI. Microcephaly at 12 months was more frequent in children with abnormal DWI.
Conclusion: In survivors of moderate neonatal HIE, abnormal brain DWI sequence might predict inappropriate head growth, and need close medical and nutritional interventions for growth improvement.
Key words: Hypoxic ischemia encephalopathy, Magnetic resonance imaging, Diffusion weighted imaging, Microcephaly, Underweight.
Intrauterine autologous platelet-rich plasma treatment in women with at least two implantation failures: A retrospective cohort study
Authors: Meybodi Neda Fattahi , Eftekhar Maryam , Gandom Behnaz
Published: February 2024

Background: Finding the most effective way to improve implantation rate in women who are receiving assisted reproductive technology treatment is still a challenge.
Objective: This study aimed to assess the pregnancy outcomes of intrauterine platelet-rich plasma (PRP) therapy in women with a history of at least 2 implantation failures.
Materials and Methods: In this retrospective cohort study, data of 852 women who were candidates for frozen-thawed embryo transfer was extracted from their medical records from April 2017-September 2021 at Yazd Reproductive Sciences Institute, Yazd, Iran. Of these, 432 received intrauterine PRP treatment 48 hr before transfer (PRP group), and the results of the pregnancy outcomes compared with 420 of the control group who did not receive the treatment before transfer.
Results: Pregnancy outcomes, including chemical, clinical, ongoing pregnancy, and live birth rate were statistically significant in the PRP group (p < 0.001). However, when categorized according to the implantation history, this significant improvement in all 4 was only seen in women with at least 2 prior implantation failures. In women with a history of only one implantation failure, PRP therapy significantly improved the ongoing pregnancy and live birth rate (19.5%, p = 0.04). Also, in women who received donor eggs and had repeated implantation failure, PRP improved pregnancy outcomes clinically but not statistically (p = 0.15).
Conclusion: PRP seems to be effective in improving the pregnancy rate in women with a history of 2 or more implantation failures and also shows an increase in the live birth rate in women with only one implantation failure.
Key words: Platelet-rich plasma, Embryo implantation, Assisted reproductive technology, Ovum donor, Live birth rate.
Sertoli cell-conditioned medium can improve blood-testis-barrier function and spermatogenesis in azoospermia mice induced by scrotal hyperthermia: An experimental study
Authors: Aghajanpour Fakhroddin , Soltani Reza , Afshar Azar , Abbaszadeh Hojjat-Allah , Fathabadi Fatemeh Fadaei , Moeinian Nafiseh , Aliaghaei Abbas , Nejad Ali Dehghani , Farahani Reza Mastery , Norouzian Mohsen , Abdollahifar Mohammad-Amin
Published: February 2024

Background: An increase in the temperature of the testis is associated with damage to the epithelium of seminiferous tubules and disruption of sperm production.
Objective: The current study aimed to investigate the effect of the Sertoli cell-conditioned medium (SCCM) on the blood-testis-barrier associated genes and spermatogenesis process following scrotal hyperthermia.
Materials and Methods: In this experimental study, 40 adult NMRI mice (8 wk, 25–30 gr) were allocated into 4 groups: I) control, II) DMEM (10 μl Dulbecco’s Modified Eagle Medium), III) scrotal hyperthermia, and IV) scrotal hyperthermia+SCCM (10 μl SCCM). Hyperthermia was induced by placing the mice scrotum in water at 43°C for 20 min every other day for 10 days. Mice were treated every other day for 5 wk. Then the animals were euthanized, and the tails of epididymis were removed to analyze sperm parameters, testis were taken for stereological assessment, reactive oxygen spices and glutathione levels, and the expression of Ocln, Gja1, Cdh2, and Itgb1.
Results: The results of sperm analysis indicated that SCCM-treated mice significantly increased sperm count and motility and reduced DNA fragmentation. In addition, histological and molecular findings showed that the volume of testicular tissue, the number of germ cells, the glutathione level, and the expression of Ocln, Gja1, Cdh2, and Itgb1 genes were significantly increased in the SCCM-treated mice.
Conclusion: Findings suggest that growth factors of SCCM stimulate the proliferation and differentiation of germ cells through paracrine effects and upregulate the blood-testis-barrier-associated genes in mice subjected to scrotal hyperthermia.
Key words: Testis, Sertoli cells, Culture media, Hyperthermia, Spermatogenesis.
Chronic demyelination interferes with normal spermatogenesis in cuprizone-intoxicant C57/BL 6 mice: An experimental study
Authors: Dorikhani Arezoo , Omidi Ameneh , Movahedin Mansoureh , Halvaei Iman
Published: February 2024

Background: Due to myelin and axonal insults in multiple sclerosis individuals, motor coordination problems and endocrine imbalance may develop.
Objective: This study aims to evaluate the role of chronic demyelination on the hypothalamic-pituitary-gonadal axis in the mouse model of multiple sclerosis.
Materials and Methods: 20 adult C57/BL6 male mice were divided into 2 groups (n = 10/each) as follows: the control group (CONT) received a regular diet for 17 wk; and the experimental group (cuprizone [CPZ]) was fed with 0.2% CPZ for 12 wk and, then CPZ was withdrawn for 5 wk. Serum testosterone, histopathology of the brain and testis, and sperm analysis were evaluated.
Results: The hypothalamic myelin content was significantly decreased in the arcuate nucleus following the 12 wk of CPZ consumption compared to the CONT group, and the statistical difference remained until 17 wk. Testosterone levels declined significantly in the CPZ group compared to the CONT group in the 12th and 17th wk. A significant decrease was observed in the height of the seminiferous epithelium and the interstitial tissue area, and the number of seminiferous epithelial cells in the CPZ group compared to the CONT group in the 12th and 17th wk. The sperm count, motility, and viability in the CPZ group significantly decreased compared to the CONT group in the 12th and 17th wk of the study.
Conclusion: Chronic demyelination induced by CPZ intoxication, maybe through damage to the hypothalamus arcuate nucleus, leads to the hypothalamic-pituitary-gonadal axis disturbance and damage to the testis and spermatogenesis subsequently.
Key words: Multiple sclerosis, Cuprizone, Hypothalamic-pituitary-gonadal axis, Spermatogenesis.
Evaluation of diagnostic value of pelvic MRI in endometriosis in comparison with surgical findings: A cross-sectional study
Authors: Moghadam Reza Nafisi , Tamizi Fatemeh , Ratki Seid Kazem Razavi , Moghadam Amin Nafisi , Javaheri Atiyeh , Namiranian Nasim
Published: February 2024

Background: Endometriosis is a multifocal gynecologic disorder during the fertility period in women. Magnetic resonance imaging (MRI) is an important diagnostic modality for this disease and can either be used alone or along with transvaginal ultrasonography.
Objective: This study aims to compare the accuracy of pelvis MRI in pelvic deep endometriosis with laparoscopic findings in women referred to Shahid Sadoughi hospital in one yr.
Materials and Methods: This cross-sectional study was conducted on 40 women suspicious of endometriosis who referred to Shahid Sadoughi hospital, Yazd, Iran from November 2020-2021. Based on clinical findings and history, participants were referred to the imaging center for pelvic MRI. Finally, the results of MRI and diagnostic laparoscopy were compared with pathologic findings.
Results: The sensitivity and specificity of MRI for pelvic endometriosis were 94.8% and 20%, respectively. Also, the positive predictive value and negative predictive value of MRI were 90.2% and 33.3%, respectively.
Conclusion: Laparoscopy is still the gold standard of endometriosis diagnosis, but MRI with susceptibility-weighted imaging sequence is the best noninvasive diagnostic method.
Key words: Deep infiltrating endometriosis, Magnetic resonance imaging, Diagnosis, Laparoscopy, Sensitivity, Specificity.
The genetically modified human foreskin fibroblast cell line (YhFF#8) stably expressing Cas9 gene: A lab resource report
Authors: Soheilipour Farzad , Boozarpour Sohrab , Aghaei Shiva , Yazd Ehsan Farashahi
Published: February 2024

Background: Stable Cas9 (CRISPR-associated protein 9)-expressing cell lines have emerged as valuable tools in genetic research, enhancing the efficiency of the CRISPR/Cas9 system and streamlining gene editing procedures. These cell lines enable simultaneous editing of multiple genes and reduce the overall editing time.
Objective: This study aimed to develop a stable human fibroblast cell line capable of genetic conversion into a mutant form, serving as a cellular model for a specific genetic disease. The established cell line facilitates investigation of disease mechanisms, testing of potential treatments, and gaining insights into underlying molecular processes.
Materials and Methods: Human embryonic kidney 293LTV cells were used to produce pseudo-virus particles, while Yazd human foreskin fibroblasts batch 8 (YhFF#8) cells were targeted for genetic modification. Transfection of human embryonic kidney 293LTV cells with pCDH-Cas9 plasmid DNA generated pseudo-viral particles. YhFF#8 cells were transduced and selected using antibiotics. Green fluorescent protein (GFP) detection confirmed successful transduction and selection. Relative expression levels of the Cas9 gene were determined by quantitative polymerase chain reaction.
Results: The study validated the fidelity of the Cas9 gene cassette sequence and its transcriptional activity. Transduced YhFF#8 cells exhibited green fluorescence, with antibiotic selection resulting in nearly 100% transduced cells. A reporter GFP gene enabled real-time monitoring of YhFF#8-Cas9-GFP-PuroR cells using fluorescence microscopy.
Conclusion: YhFF#8-Cas9-GFP-PuroR cells, labeled and susceptible to genomic editing, provide an optimal source for generating induced pluripotent stem cell lines for future biomedical research.
Key words: Fibroblasts, Cell line, Genetic transduction, CRISPR-Cas9.
Aspirin administration from early pregnancy versus initiation after 11 weeks of gestation for prevention of pre-eclampsia in high-risk pregnant women: Study protocol for randomized controlled trial
Authors: Hantoushzadeh Sedigheh , Behzadian Arezoo , Hasheminejad Mohammad Mehdi , Hasheminejad Faezeh , Birjandi Alireza Helal , Akbari Mojtaba , Ghaemi Marjan
Published: February 2024

Background: Pre-eclampsia (PE) is a multiorgan disorder that affects 2–5% of all pregnant women. Present recommendations for when to start aspirin in high-risk women are after 11 wk of gestation.
Objective: We present a protocol to investigate the effectiveness of aspirin use from early pregnancy, which is a randomized controlled trial to assess whether prescribed low-dose aspirin from early pregnancy reduces the prevalence of early and late-onset PE. Additionally, to compare the effectiveness of aspirin administration before and after 11 wk in reducing the occurrence of PE?
Materials and Methods: All pregnancies at risk of PE, according to demographic and midwifery history, who are referred to the Maternal-Fetal Clinic of Tehran University hospital, Tehran, Iran were invited to take part in the trial. The outcomes of pregnancy and newborns will be gathered and analyzed. The first registration for the pilot study was in January 2023, and the participants were recognized as high-risk for PE. In addition, enrollment in the main study will begin as of October 2023. Key words: Pre-eclampsia, Aspirin, Color doppler ultrasonography, Pregnancy, First trimester, Pregnancy-associated plasma protein-A.
Key words: Pre-eclampsia, Aspirin, Color doppler ultrasonography, Pregnancy, First-trimester, Pregnancy-associated plasma protein-A.
Magnetic Field as a Tool for Enhancing β -Lactamase Activity
Authors: Vasić Katja , Primožič Mateja , Trbušić Mislav , Goričan Viktor , Jesenik Marko , Hamler Anton , Knez Željko , Yürekli Yilmaz , Leitgeb Maja
Published: February 2024

β-Lactam antibiotics have been extensively employed in bacterial treatment ever since penicillin's groundbreaking discovery. Despite the proliferation of antibiotics in the pharmaceutical sector today, bacteria often evolve defense mechanisms. Chief among these is the production of β-lactamase enzymes, which degrade β-lactam antibiotics, representing a prevalent form of antibiotic resistance. Additionally, these antibiotics exhibit limited biodegradability, with only 20% breaking down naturally. Hence, finding effective methods to mitigate the presence of β-lactam antibiotics is crucial in combating antibiotic pollution.
Techno-Economic Model of Multimodal Transport
Authors: Poul David , Gregor Jiří , Pavlas Martin , Fan Yee Van
Published: February 2024

With the current effort to reduce transport emissions, the shift in the transport of goods from road to rail or combination is expected on a larger scale. For this shift to have the expected results, it needs to be supported by detailed project planning and calculation. The paper presents the techno-economic model of multimodal transport, focusing on road and rail transport. The model includes a vast database of transport systems for both types of transport. To complete the logistic chain, the model includes the calculation for transfer stations, handling equipment, and other needed parts. The model also includes an economic evaluation allowing analysis of the whole logistic chain of multimodal transport or performing the comparison of individual types of transport.
In vitro Evaluation of Different Levels of Cashew (Anacardium occidentale) Nut Meal Supplementation on Rumen Fermentation Kinetics and Digestibility
Authors: Rashmi K.M. , Prabhu T.M. , Patil Vivek M. , Madhusudhan H.S. , Soren N.M. , Giridhar K.S. , Pandey Hemantkumar
Published: February 2024

Background: Globally, safeguarding food and nutritional security of ever increasing population demands sustainable crop and livestock production. While urbanization, decrease in cultivable land and stiff feed-fuel-food competition accompanied with skyrocketing price of conventional feedstuffs hinders the sustainable livestock production. Hence, it necessitates search and exploration of alternative feed resources along with judicious utilization of existing feed resources. In this context, Cashew nut meal (CNM) is one such alternative feed resource but the studies pertaining to its optimum level of inclusion in animal diet is scanty. Therefore, the study was conducted to assess the effect of incorporating varying levels of cashew nut meal (CNM) as a supplement on in vitro rumen fermentation kinetics and digestibility. Methods: Seven distinct compounded feed mixtures (CFM) were formulated, with CNM progressively replacing 0 (C0), 10 (C1), 20 (C2), 30 (C3), 40 (C4), 50 (C5), and 60 (C6) per cent of the soybean meal (SBM) protein present in the control CFM. Additionally, seven experimental complete diets (T0 to T6) were prepared by blending these CFM with Super Napier (Pennisetum purpureum x Pennisetum glaucum) hay in a 40:60 ratio. These diets were subjected to rumen in vitro gas production (RIVGP) study with cumulative gas production measured at 0, 2, 4, 6, 8, 12, 16, 24, 36, 48, 60, 72 and 96 h post-incubation. Subsequently, in vitro dry matter digestibility (IVTDMD) and neutral detergent fiber digestibility (NDFD) of the diets were determined using a modified in vitro two-stage technique. Later, total volatile fatty acids (TVFA) were estimated using gas chromatography. Result: Analysis of chemical composition revealed that CNM contains good protein of 256.5 g/kg. The potential gas production (D) and the rate and extent of gas production (c) for diets containing CNM ranged from 54.63 to 60.24 mL and 0.036 to 0.043 h-1, respectively. IVTDMD and NDFD analysis of the seven diets fell within the range of 79.12% to 80.80% and 64.72% to 66.47%, respectively. The estimated TVFA for seven diets ranged from 17.87 to 23.65 mM. Further, the metabolisable energy (ME) of diets ranged from 7.89 to 8.08 MJ/kg DM. Importantly, no significant differences were observed in rumen fermentation kinetics parameters, IVTDMD, NDFD and TVFA among treatments (T0 to T6). In conclusion, cashew nut meal could be used as an alternative to soybean meal in compounded feed mixtures of ruminants up to 30% (w/w) without any adverse effect on rumen fermentation pattern and digestibility.
Sete proposições sobre o conceito de autenticidade e seu uso nas práticas do patrimônio histórico
Authors: Choay Françoise , Mugayar Kuhl Beatriz
Published: February 2024

Este texto de Choay foi escrito originalmente para a Conferência de Nara sobre a Autenticidade, organizada pela UNESCO e pela Agência de Negócios da Cultura do Japão. Trata-se de escrito relevante pelo rigor das análises sobre o termo autenticidade, que desempenha papel primordial nos critérios para o Patrimônio Mundial, mas cuja definição permanece imprecisa. Choay evidencia que os diversos campos disciplinares deveriam operar a partir de definição unívoca e questionamento epistemológico dos conceitos que utiliza. É esse exercício de grande valia que ela faz, retomando a história do conceito de autenticidade na cultura ocidental e perscrutando suas possíveis articulações e desdobramentos para a atualidade.
Françoise Choay é historiadora, professora, que trabalha com questões ligadas a temas como arquitetura, urbanismo e preservação de bens culturais.
Esta tradução buscou manter o mais próximo possível do original a construção do raciocínio, do fraseado e do próprio vocabulário de Choay. Os termos estrangeiros utilizados pela autora foram mantidos na língua original, para aproximar o leitor brasileiro à experiência tida pelos leitores de Choay em diversos âmbitos culturais a partir do livro da UNESCO. Todas as notas e referências em pé de página foram mantidas como estão no original, sem submetê-las às normas brasileiras
Cercospora Leaf Spots of Wheat in the Lowland Tropics of Santa Cruz, Bolivia
Authors: Morante Mario Coca
Published: February 2024

The cultivation of wheat (Triticum aestivum L.) in the lowland tropics of Santa Cruz department in Bolivia is recent. Leaf spots diseases are an important yield-reducing factor. Since 1996, Pyricularia blast wheat is the most destructive disease in tropical regions producing wheat. In 2023, sampling was carried out in different locations in the East (Cuatro cañadas) and North (Okinawa1, Okinawa2) production wheat of Santa Cruz. Leaf, sheath and glumes simples were analyzed under microscopy and were estimated incidence. Two Cercospora species, C. oryzae and C. sorghi, were recorded associated with the leaf spots of 'Motacu' variety and these leaf spots seem to be prevalent and widely distributed in the production wheat áreas in the lowland tropics of Santa Cruz, Bolivia.
Aferição, cálculo e avaliação do índice de massa corporal de servidores da UNICAMP participantes do programa MEXA-SE
Authors:   Universidade Estadual de Campinas, Zamai Carlos Aparecido , Bankoff Antonia Dalla Pria ,   Universidade Estadual de Campinas, Silva Vívian Santos Xavier ,   Universidade Estadual de Campinas
Published: February 2024

Introdução/Objetivo: Objetivou-se neste trabalho diagnosticar e aavaliar o Índice de Massa Corporal (IMC) adotado pela Organização Mundial de Saúde (OMS) de 205 servidores da Universidade Estadual de Campinas (UNICAMP). Metodologia: Participaram pessoas de ambos os sexos e faixa etária de 24 a 62 anos, que fizeram inscrição e participaram das atividades físicas do Programa Mexa-se, nos grupos da área da saúde (G1, G2 e G3) e da área administrativa (G4, G5 e G6). Foram mensurados o peso corporal, com balança digital Filizola (precisão de 100g), e a estatura, com estadiômetro Tipo Trena Sanny (precisão 0,1 cm), calculando-se os valores de IMC. As medidas de peso e altura foram aferidas no início das atividades no programa, quando houve o preenchimento da ficha de anamnese. Resultados: G1 = 25,8; G2 = 23,9 e G3 = 25,9 – Área da saúde – e Grupos G4 = 26,9; G5 = 27,1 e G6 = 25,7 – Área administrativa. Quando comparado o IMC entre os grupos das áreas saúde e administrativa, verificou-se que apenas no G2 o IMC foi inferior a 25,0. Nos demais grupos o IMC esteve acima dos padrões considerados normais. Destaca-se o IMC dos grupos 4 e 5 (26,9 e 27,1) da área administrativa, em que o IMC se classifica como excesso de peso ou obesidade leve. Verificou-se que o IMC encontra-se alterado, o que merece atenção profissional, para que os servidores recebam orientações sobre reeducação alimentar e práticas de atividades físicas diárias, inclusive no ambiente de trabalho. Conclusão: Desse modo, estes resultados são relevantes no que concerne à discussão e planejamento de estratégias mais efetivas a respeito da saúde física e de programas que fomentem, imbuindo à prática regular de atividades físicas e orientações de dieta balanceada de qualidade nutricional aos servidores.
Práticas esportivas e recreativas no ICT/CSJC
Authors:   Universidade Estadual Paulista, Goulart Reginaldo , Tavares Carla ,   Universidade Estadual Paulista
Published: February 2024

Introdução: Por meio de proposta encaminhada ao Edital nº 06/2021 - PROEC, recebemos recursos financeiros para apoiar e incentivar ações de promoção da saúde, esporte, arte e cultura como investimento no retorno das atividades presenciais. Objetivo: Desenvolver práticas esportivas em diversas modalidades para estimular a qualidade de vida, convivência e socialização. Metodologia: Realizou-se enquete na comunidade acadêmica com o objetivo de coletar quais atividades esportivas executar em nossa Unidade. A partir dos resultados, foram contratados profissionais para execução das atividades sugeridas. Resultados: Desafio Saúde: palestras de reeducação alimentar com foco em uma alimentação mais saudável, medições de bioimpedância, peso, altura, massa muscular e premiação para os melhores resultados. Educação física: exercícios de alongamento e fortalecimento muscular. Caminhada: convivência e socialização proporcionando melhoria na saúde física e mental. Campeonato esportivo: realização de jogos, com destaque para queimada, realizada no intervalo de almoço. Conclusão: O acesso às ações oferecidas proporcionou melhoria na saúde física e mental da comunidade acadêmica, através de convivência sadia e socialização harmoniosa entre os membros. Consciência por hábitos saudáveis com diminuição do sedentarismo. Sentimento de pertencimento e grupo, acolhimento de todos.