bluuebunny/crossref_metadata_2025 huggingface dataset:
Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming
Authors: Bedi Yudhishtar S. , Wang Haiqing , Thomas Kara N. , Basel Alison , Prunier Julien , Robert Claude , Golding Michael C.
Published: May 2022

Using a mouse model, studies by our group reveal that paternal preconception alcohol intake affects offspring fetal-placental growth, with long-lasting consequences on adult metabolism. Here, we tested the hypothesis that chronic preconception male alcohol exposure impacts histone enrichment in sperm and that these changes are associated with altered developmental programming in the placenta. Using chromatin immunoprecipitation, we find alcohol-induced increases in sperm histone H3 lysine 4 trimethylation (H3K4me3) that map to promoters and presumptive enhancer regions enriched in genes driving neurogenesis and craniofacial development. Given the colocalization of H3K4me3 with the chromatin binding factor CTCF across both sperm and embryos, we next examined CTCF localization in the placenta. We find global changes in CTCF binding within placentae derived from the male offspring of alcohol-exposed sires. Furthermore, altered CTCF localization correlates with dysregulated gene expression across multiple gene clusters; however, these transcriptional changes only occur in male offspring. Finally, we identified a correlation between genomic regions exhibiting alcohol-induced increases in sperm H3K4me3 and increased CTCF binding in male placentae. Collectively, our analysis demonstrates that the chromatin landscape of sperm is sensitive to chronic alcohol exposure and that a subset of these affected regions exhibits increased placental CTCF enrichment.
External validation of a triage tool for predicting cardiac arrest in the emergency department
Authors: Sun Jen-Tang , Chang Chih-Chun , Lu Tsung-Chien , Lin Jasper Chia-Cheng , Wang Chih-Hung , Fang Cheng-Chung , Huang Chien-Hua , Chen Wen-Jone , Tsai Chu-Lin
Published: May 2022

Early recognition and prevention comprise the first ring of the Chain of Survival for in-hospital cardiac arrest (IHCA). We previously developed and internally validated an emergency department (ED) triage tool, Emergency Department In-hospital Cardiac Arrest Score (EDICAS), for predicting ED-based IHCA. We aimed to externally validate this novel tool in another ED population. This retrospective cohort study used electronic clinical warehouse data from a tertiary medical center with approximately 130,000 ED visits per year. We retrieved data from 268,208 ED visits over a 2-year period. We selected one ED visit per person and excluded out-of-hospital cardiac arrest or children. Patient demographics and computerized triage information were retrieved, and the EDICAS was calculated to predict the ED-based IHCA. A total of 145,557 adult ED patients were included. Of them, 240 (0.16%) developed IHCA. The EDICAS showed excellent discrimination with an area under the receiver operating characteristic (AUROC) of 0.88. The AUROC of the EDICAS outperformed those of other early warning scores (0.80 for Modified Early Warning Score [MEWS] and 0.83 for Rapid Emergency Medicine Score [REMS]) in the same ED population. An EDICAS of 6 or above (i.e., high-risk patients) corresponded to a sensitivity of 33%, a specificity of 97%, and a positive likelihood ratio of 12.2. In conclusion, we externally validated a tool for predicting imminent IHCA in the ED and demonstrated its superior performance over other early warning scores. The real-world impact of the EDICAS warning system with appropriate interventions would require a future prospective study.
Effect of heat exposure on the growth and developmental competence of bovine oocytes derived from early antral follicles
Authors: Kawano Kohei , Sakaguchi Kenichiro , Madalitso Chelenga , Ninpetch Nattapong , Kobayashi Shintaro , Furukawa Eri , Yanagawa Yojiro , Katagiri Seiji
Published: May 2022

In dairy cows, low fertility caused by summer heat stress continues into the cooler autumn season. This can be caused by impaired oocyte quality in small growing follicles during summer. Here, we subjected oocyte–cumulus–granulosa complexes (OCGCs) derived from early antral follicles (0.5–1 mm) to in vitro growth (IVG) culture under two different temperature settings (the control and heat shock groups), and evaluated effects of heat exposure on growth and developmental competence of oocytes, factors affecting the developmental competence of oocytes (steroidogenesis of granulosa cells, oxidative stress in oocytes, and cell-to-cell communication between oocytes and somatic cells). Oocyte diameters after culture were smaller in the heat shock group. Although nuclear maturation and cleavage rates were similar between the groups, blastocyst rates were lower in the heat shock group (0.0%) than in the control group (27.7%), and reduced glutathione (GSH) levels in oocytes were lower in the heat shock group. Supplementation of cysteine, which stimulates GSH synthesis, increased GSH level and improved blastocyst rate of heat shocked oocytes (27.9%). These results suggest that heat exposure impairs the growth and developmental competence of oocytes in early antral follicles through GSH depletion, which can induce low fertility during summer and the following autumn.
Assessing the impacts of agricultural drought (SPI/SPEI) on maize and wheat yields across Hungary
Authors: Mohammed Safwan , Alsafadi Karam , Enaruvbe Glory O. , Bashir Bashar , Elbeltagi Ahmed , Széles Adrienn , Alsalman Abdullah , Harsanyi Endre
Published: May 2022

This study examined the physical properties of agricultural drought (i.e., intensity, duration, and severity) in Hungary from 1961 to 2010 based on the Standardized Precipitation Index (SPI) and the Standardized Precipitation Evapotranspiration Index (SPEI). The study analyzed the interaction between drought and crop yield for maize and wheat using standardized yield residual series (SYRS), and the crop-drought resilient factor (CDRF). The results of both SPI and SPEI (-3, -6) showed that the western part of Hungary has significantly more prone to agricultural drought than the eastern part of the country. Drought frequency analysis reveals that the eastern, northern, and central parts of Hungary were the most affected regions. Drought analysis also showed that drought was particularly severe in Hungary during 1970–1973, 1990–1995, 2000–2003, and 2007. The yield of maize was more adversely affected than wheat especially in the western and southern regions of Hungary (1961–2010). In general, maize and wheat yields were severely non-resilient (CDRF < 0.8) in the central and western part of the country. The results suggest that drought events are a threat to the attainment of the second Sustainable Development Goals (SDG-2). Therefore, to ensure food security in Hungary and in other parts of the world, drought resistant crop varieties need to be developed to mitigate the adverse effects of climate change on agricultural production.
Groundwater irrigation reduces overall poverty but increases socioeconomic vulnerability in a semiarid region of southern India
Authors: Fischer Chloé , Aubron Claire , Trouvé Aurélie , Sekhar Muddu , Ruiz Laurent
Published: May 2022

The development of irrigation is generally considered an efficient way to reduce poverty in rural areas, although its impact on the inequality between farmers is more debated. In fact, assessing the impact of water management on different categories of farmers requires resituating it within the different dimensions of the local socio-technical context. We tested this hypothesis in a semi-arid area in Karnataka, South India, where groundwater irrigation was introduced five decades ago. Using the conceptual framework of comparative agriculture, based on farmers’ interviews, we built a farm typology, traced the trajectories of farm types over the last decades and assessed their current technical and economic performances. Our results show that the differentiation of farm trajectories since the 1950s has been linked with the development of groundwater irrigation, interplaying with their initial assets, and the evolution of the national and local contexts. We highlight the mechanisms by which irrigation indeed reduces poverty but engenders fragilities, particularly for poor households, whose situation was aggravated by the depletion of water resources over the last two decades. Finally, this extensive understanding of the agrarian context allowed us to formulate and assess the potential of different ways forward, including irrigation technology, change in cropping or livestock systems, land tenure, and value added distribution. As such, this analysis would be of major interest to policy makers involved in reforming the agricultural context for better agricultural water management.
Comparative transcriptome profiles of human dental pulp stem cells from maxillary and mandibular teeth
Authors: Faruangsaeng Thira , Thaweesapphitak Sermporn , Khamwachirapitak Chompak , Porntaveetus Thantrira , Shotelersuk Vorasuk
Published: May 2022

The molecular control of tooth development is different between the maxilla and mandible, contributing to different tooth shapes and locations; however, whether this difference occurs in human permanent teeth is unknown. The aim of this study was to investigate and compare the transcriptome profiles of permanent maxillary and mandibular posterior teeth. Ten participants who had a pair of opposing premolars or molars extracted were recruited. The RNA obtained from cultured dental pulp stem cells underwent RNA-sequencing and qRT-PCR. The transcriptome profiles of two opposing premolar pairs and two molar pairs demonstrated that the upper premolars, lower premolars, upper molars, and lower molars expressed the same top-ranked genes, comprising FN1, COL1A1, COL1A2, ACTB, and EEFIA1, which are involved in extracellular matrix organization, immune system, signal transduction, hemostasis, and vesicle-mediated transport. Comparative transcriptome analyses of each/combined tooth pairs demonstrated that PITX1 was the only gene with different expression levels between upper and lower posterior teeth. PITX1 exhibited a 64-fold and 116-fold higher expression level in lower teeth compared with their upper premolars and molars, respectively. These differences were confirmed by qRT-PCR. Taken together, this study, for the first time, reveals that PITX1 is expressed significantly higher in mandibular posterior teeth compared with maxillary posterior teeth. The difference is more evident in the molars compared with premolars and consistent with its expression pattern in mouse developing teeth. We demonstrate that differences in lower versus upper teeth gene expression during odontogenesis occur in permanent teeth and suggest that these differences should be considered in molecular studies of dental pulp stem cells. Our findings pave the way to develop a more precise treatment in regenerative dentistry such as gene-based therapies for dentin/pulp regeneration and regeneration of different tooth types.
Long-term seed burial reveals differences in the seed-banking strategies of naturalized and invasive alien herbs
Authors: Moravcová Lenka , Carta Angelino , Pyšek Petr , Skálová Hana , Gioria Margherita
Published: May 2022

Soil seed viability and germinability dynamics can have a major influence on the establishment and spread of plants introduced beyond their native distribution range. Yet, we lack information on how temporal variability in these traits could affect the invasion process. To address this issue, we conducted an 8-year seed burial experiment examining seed viability and germinability dynamics for 21 invasive and 38 naturalized herbs in the Czech Republic. Seeds of most naturalized and invasive species persisted in the soil for several years. However, naturalized herbs exhibited greater seed longevity, on average, than invasive ones. Phylogenetic logistic models showed that seed viability (but not germinability) dynamics were significantly related to the invasion status of the study species. Seed viability declined earlier and more sharply in invasive species, and the probability of finding viable seeds of invasive species by the end of the experiment was low. Our findings suggest that invasive herbs might take advantage of high seed viability in the years immediately after dispersal, while naturalized species benefit from extended seed viability over time. These differences, however, are not sufficiently strong to explain the invasiveness of the species examined.
Midfrontal theta power encodes the value of haptic delay
Authors: Alsuradi Haneen , Park Wanjoo , Eid Mohamad
Published: May 2022

The use of haptic technologies in modern life scenarios is becoming the new normal particularly in rehabilitation, medical training, and entertainment applications. An evident challenge in haptic telepresence systems is the delay in haptic information. How humans perceive delayed visual and audio information has been extensively studied, however, the same for haptically delayed environments remains largely unknown. Here, we develop a visuo-haptic experimental setting that simulates pick and place task and involves continuous haptic feedback stimulation with four possible haptic delay levels. The setting is built using a haptic device and a computer screen. We use electroencephalography (EEG) to study the neural correlates that could be used to identify the amount of the experienced haptic delay. EEG data were collected from 34 participants. Results revealed that midfrontal theta oscillation plays a pivotal role in quantifying the amount of haptic delay while parietal alpha showed a significant modulation that encodes the presence of haptic delay. Based on the available literature, these results suggest that the amount of haptic delay is proportional to the neural activation that is associated with conflict detection and resolution as well as for multi-sensory divided attention.
Personality mediates the association between juvenile conduct problems and adulthood mood disorders
Authors: Chan Jen-Hui , Chen Hsi-Chung , Chen I.-Ming , Wang Tsung-Yang , Chien Yi-Ling , Wu Shu-I. , Kuo Po-Hsiu
Published: May 2022

This study aimed to examine the association between conduct problems and mood disorders, and to evaluate the mediating roles of personality traits in it. Adult participants (N = 309), for which patients with major depressive disorder (MDD) or bipolar disorder (BD), and controls without major psychiatric history were recruited. Juvenile conduct problem was defined by the items in Composite International Diagnosis Interview. We assessed personality traits of extraversion and neuroticism. Multiple mediation model was performed to investigate the intervening effect of personality traits between juvenile conduct problems and adulthood mood disorders. Participants had on average 2.7 symptoms of conduct problems, and 43.4% had conduct problems. Having more symptoms of conduct problems was associated with a higher likelihood of BD (OR = 1.20). Higher neuroticism was associated with elevated risks of both MDD and BD. There was no direct effect of binary conduct problems on the risk of BD, and showed significant total indirect effect mediated by neuroticism for BD (OR = 1.49; bias-corrected and accelerated 95% CI = 1.10–2.05), but not through extraversion. Conduct problems defined as a continuous variable had a direct effect on the risk of adult MDD (OR = 1.36; bias-corrected and accelerated 95% CI = 1.05–1.76), while had an indirect effect on the risk of BD via the mediation of neuroticism (OR = 1.08; bias-corrected and accelerated 95% CI = 1.02–1.14). Neuroticism mediates between the association of juvenile conduct problems and adult BD. This finding raises our attention to assess personality traits in individuals with juvenile conduct problems for timely intervention strategies of reducing the vulnerability for developing mood disorders.
Preclinical evaluation of endoscopic placement of a steroid-eluting metal stent in an in vivo porcine benign biliary stricture model
Authors: Jang Sung Ill , Fang Sungsoon , Nahm Ji Hae , Cho Jae Hee , Do Min Young , Lee Su Yeon , Jeong Seok , Lee Don Haeng , Lee Dong Ki
Published: May 2022

Treatment of benign biliary strictures (BBS) using fully covered self-expandable metal stents (FCSEMS) has a high success rate, but recurrence can occur. Corticosteroids may be useful based on their anti-fibrotic and anti-inflammatory effects. We investigated the safety and efficacy of corticosteroid-eluting FCSEMS in an animal model. BBSs were created by radiofrequency ablation in 12 mini-pigs. Four weeks later, FCSEMS coated with 0 mg (control), 15 mg (steroid 1 × group), or 30 mg (steroid 2 × group) triamcinolone were inserted endoscopically. The in vitro drug release assay revealed that the optimal stent had 15 mg of triamcinolone and a hydrophilic membrane. No transmural necrosis or perforation occurred in any animal. Fibrous wall thickness tended to decrease macroscopically and microscopically in a triamcinolone dose-dependent manner (control vs. steroid 2 × group: 773.1 vs. 468.5 µm, P = 0.037). Thickness also decreased over time in the steroid 2 × group (3 days vs. 4 weeks: 907.9 vs. 468.5 µm, P = 0.025). Blood parameters tended to improve after stent insertion. In a porcine BBS model, steroid-eluting FCSEMS showed potential as a safe and effective treatment modality to reduce fibrotic tissue. Studies are required to confirm their safety and efficacy in humans with refractory BBS.
Static test research on steel bridge deck pavement structures paved by high-content hybrid fibre polymer concrete
Authors: Zhao Chaohua , Zhu Zhiwei , Yi Zhijian , Su Kang , Li Ya
Published: May 2022

Steel bridge deck pavement has always been a key and difficult point in the construction of long-span bridges. In practical engineering, common paving material is asphalt, and serious damage is caused on the pavement layer in the early stage. In this study, a high-performance high-content hybrid fibre polymer concrete was used as the paving material. A test was conducted on the small beam of the composite structure formed by the pavement layer and steel plate, and a positive/negative bending moment test was conducted to analyse the stiffness and bearing capacity of the composite structure. As revealed in the research results, the flexural and tensile stiffness of the structure and the bearing capacity of the composite structure showed superior performance, increased significantly with the pavement thickness, but increased slowly after the pavement thickness exceeded 80 mm and the increase in thickness contributed little to the bearing capacity. Under the simulated action of a positive/negative bending moment, the pavement layer still exhibited certain ductile failure features when the structure was bearing an ultimate load. This proves that high-content hybrid fibre polymer concrete exhibits suitable mechanical properties for steel bridge deck pavement.
Signaling events evoked by domain III of envelop glycoprotein of tick-borne encephalitis virus and West Nile virus in human brain microvascular endothelial cells
Authors: Bhide Katarína , Mochnáčová Evelína , Tkáčová Zuzana , Petroušková Patrícia , Kulkarni Amod , Bhide Mangesh
Published: May 2022

Tick-borne encephalitis virus and West Nile virus can cross the blood–brain barrier via hematogenous route. The attachment of a virion to the cells of a neurovascular unit, which is mediated by domain III of glycoprotein E, initiates a series of events that may aid viral entry. Thus, we sought to uncover the post-attachment biological events elicited in brain microvascular endothelial cells by domain III. RNA sequencing of cells treated with DIII of TBEV and WNV showed significant alteration in the expression of 309 and 1076 genes, respectively. Pathway analysis revealed activation of the TAM receptor pathway. Several genes that regulate tight-junction integrity were also activated, including pro-inflammatory cytokines and chemokines, cell-adhesion molecules, claudins, and matrix metalloprotease (mainly ADAM17). Results also indicate activation of a pro-apoptotic pathway. TLR2 was upregulated in both cases, but MyD88 was not. In the case of TBEV DIII, a MyD88 independent pathway was activated. Furthermore, both cases showed dramatic dysregulation of IFN and IFN-induced genes. Results strongly suggest that the virus contact to the cell surface emanates a series of events namely viral attachment and diffusion, breakdown of tight junctions, induction of virus uptake, apoptosis, reorganization of the extracellular-matrix, and activation of the innate immune system.
Amplification of cell signaling and disease resistance by an immunity receptor Ve1Ve2 heterocomplex in plants
Authors: Kalischuk Melanie , Müller Boje , Fusaro Adriana F. , Wijekoon Champa P. , Waterhouse Peter M. , Prüfer Dirk , Kawchuk Lawrence
Published: May 2022

Immunity cell-surface receptors Ve1 and Ve2 protect against fungi of the genus Verticillium causing early dying, a worldwide disease in many crops. Characterization of microbe-associated molecular pattern immunity receptors has advanced our understanding of disease resistance but signal amplification remains elusive. Here, we report that transgenic plants expressing Ve1 and Ve2 together, reduced pathogen titres by a further 90% compared to plants expressing only Ve1 or Ve2. Confocal and immunoprecipitation confirm that the two receptors associate to form heteromeric complexes in the absence of the ligand and positively regulate signaling. Bioassays show that the Ve1Ve2 complex activates race-specific amplified immunity to the pathogen through a rapid burst of reactive oxygen species (ROS). These results indicate a mechanism by which the composition of a cell-surface receptor heterocomplex may be optimized to increase immunity against devastating plant diseases.
Proline utilization A controls bacterial pathogenicity by sensing its substrate and cofactors
Authors: Ye Peiyi , Li Xia , Cui Binbin , Song Shihao , Shen Fangfang , Chen Xiayu , Wang Gerun , Zhou Xiaofan , Deng Yinyue
Published: May 2022

Previous reports indicate that proline utilization A (PutA) is involved in the oxidation of proline to glutamate in many bacteria. We demonstrate here that in addition to its role in proline catabolism, PutA acts as a global regulator to control the important biological functions and virulence of Ralstonia solanacearum. PutA regulates target gene expression levels by directly binding to promoter DNA, and its regulatory activity is enhanced by L-proline. Intriguingly, we reveal that the cofactors NAD+ and FAD boost the enzymatic activity of PutA for converting L-proline to L-glutamic acid but inhibit the regulatory activity of PutA for controlling target gene expression. Our results present evidence that PutA is a proline metabolic enzyme that also functions as a global transcriptional regulator in response to its substrate and cofactors and provide insights into the complicated regulatory mechanism of PutA in bacterial physiology and pathogenicity.
Quantifying telomeric lncRNAs using PNA-labelled RNA-Flow FISH (RNA-Flow)
Authors: González-Vasconcellos Iria , Cobos-Fernández María A. , Atkinson Michael J. , Fernandez-Piqueras José , Santos Javier
Published: May 2022

Here we present a method to detect and quantify long non-coding RNAs, in particular those related to telomeres. By coupling the specificity of a peptide nucleic acid (PNA) probe with flow cytometry we have quantified cellular levels of TERRA and TERC lncRNAs in culture cell lines and PBMCs. This easy-to-use method appointed RNA-Flow allows reliable lncRNA quantification with broad applications in basic research and clinical diagnostics. In addition, the staining protocol presented here was proven useful for the detection and quantification of such lncRNAs on unfixed cells using confocal microscopy.
Phonon-assisted formation of an itinerant electronic density wave
Authors: Li Jiaruo , Gorobtsov Oleg Yu. , Patel Sheena K. K. , Hua Nelson , Gregory Benjamin , Shabalin Anatoly G. , Hrkac Stjepan , Wingert James , Cela Devin , Glownia James M. , Chollet Matthieu , Zhu Diling , Medapalli Rajasekhar , Fullerton Eric E. , Shpyrko Oleg G. , Singer Andrej
Published: May 2022

Electronic instabilities drive ordering transitions in condensed matter. Despite many advances in the microscopic understanding of the ordered states, a more nuanced and profound question often remains unanswered: how do the collective excitations influence the electronic order formation? Here, we experimentally show that a phonon affects the spin density wave (SDW) formation after an SDW-quench by femtosecond laser pulses. In a thin film, the temperature-dependent SDW period is quantized, allowing us to track the out-of-equilibrium formation path of the SDW precisely. By exploiting its persistent coupling to the lattice, we probe the SDW through the transient lattice distortion, measured by femtosecond X-ray diffraction. We find that within 500 femtoseconds after a complete quench, the SDW forms with the low-temperature period, directly bypassing a thermal state with the high-temperature period. We argue that a wavevector-matched phonon launched by the quench changes the formation path of the SDW through the dynamic pinning of the order parameter.
Construction of unique heterojunction photoanodes through in situ quasi-epitaxial growth of FeVO4 on Fe2O3 nanorod arrays for enhanced photoelectrochemical performance
Authors: Zhu Wenwu , Wei Yiqing , Liu Zhengchu , Zhang Yongcai , He Huichao , Yang Shaoguang , Li Zhengdao , Zou Zhigang , Zhou Yong
Published: May 2022

By enhancing the separation of photogenerated electron–hole pairs, reducing carrier recombination and the impedance of the interface electrolyte, the FeVO4–Fe2O3 photoanode exhibits obviously enhanced photoelectrochemical performance.
An excited state intramolecular proton transfer induced phosphate ion targeted ratiometric fluorescent switch to monitor phosphate ions in human peripheral blood mononuclear cells
Authors: Das Sangita , Das Partha Pratim , Walton James. W. , Ghoshal Kakali , Patra Lakshman , Bhattacharyya Maitree
Published: May 2022

Detection of biological phosphate is very important for environmental and health care applications.
Hydrobiogechemical interactions in the hyporheic zone of a sulfate-impacted, freshwater stream and riparian wetland ecosystem
Authors: Torgeson Joshua M. , Rosenfeld Carla E. , Dunshee Aubrey J. , Duhn Kelly , Schmitter Riley , O'Hara Patrick A. , Ng G. H. Crystal , Santelli Cara M.
Published: May 2022

Biogeochemical cycling of S, Fe, and C in the hyporheic zone is influenced by dynamic hydrologic conditions.
Critical review of antibiotic resistance genes in the atmosphere
Authors: Kormos David , Lin Kaisen , Pruden Amy , Marr Linsey C.
Published: May 2022

Our critical review compares ARG profiles in the atmosphere across different locations and discusses characterization methods, atmospheric transport, and future research questions.
The development of a rapid monitoring method for radiocesium in seawater in the Fukushima region
Authors: Torad Nagy L. , Kanai Ramon , Ishikawa Kohei , Kamimura Ryuichi , Kawamoto Tohru , Tanaka Hisashi
Published: May 2022

A new monitoring method has been developed for the rapid assessment of low levels of 137-Cs and its effective concentration and quantification in Fukushima seawater, directly using KCuHCF slurry ink with a 137-Cs recovery exceeding 99% within 30 min.
Mixed membrane matrices (MMMs) based on Nafion® pristine/defected-UiO-66(Zr) MOFs: assessment of the effects of dopants on cluster morphology
Authors: Haghighi Asl M. , Moosavi F. , Akbari S.
Published: May 2022

Cluster formation within proton exchange membrane fuel cells (PEMFCs) considerably affects the fuel cell's proton transfer performance.
Hydrogenation ofn-octanoic acid over the MoPt alloy of Mo–Pt/SiO2catalyst under solvent-free conditions
Authors: Tamura Masazumi , Yugeta Kohei , Nakagawa Yoshinao , Tomishige Keiichi
Published: May 2022

MoPt alloy in Mo–Pt/SiO2catalyst was effective for the hydrogenation ofn-octanoic acid to 1-octanol at a low reaction temperature of 373 K under neat reaction conditions.
Dynamic evolution of Al species in the hydrothermal dealumination process of CHA zeolites
Authors: Fan Benhan , Zhu Dali , Wang Linying , Xu Shutao , Wei Yingxu , Liu Zhongmin
Published: May 2022

The dynamic evolution of Al species in the hydrothermal dealumination process of CHA zeolite was investigated by multiple solid-state NMR methods. Two types of Al–OH species were clearly distinguished by 1H–1H DQ-SQ MAS NMR.
Pt(ii) complex containing the 1R,2R enantiomer of trans-1,2-diamino-4-cyclohexene ligand effectively and selectively inhibits the viability of aggressive pancreatic adenocarcinoma cells and alters their lipid metabolism
Authors: Novohradsky Vojtech , Markova Lenka , Kostrhunova Hana , Svitelova Marie , Kasparkova Jana , Barbanente Alessandra , Papadia Paride , Margiotta Nicola , Hoeschele James D. , Brabec Viktor
Published: May 2022

New compounds structurally derived from oxaliplatin exhibit high potency in malignant pancreatic adenocarcinoma cells. Their mechanism of antiproliferative action in pancreatic cancer cells involves inhibition of de novo lipid synthesis.
Tandem 1,6-addition/cyclopropanation/rearrangement reaction of vinylogous para-quinone methides with 3-chlorooxindoles: construction of vicinal quaternary carbon centers
Authors: Pan Yuan , Ren Weiwu , Zhang Zhanhao , Luo Fengbiao , Hou Xiaohan , Li Xiaoyang , Yang Yun-Fang , Wang Yang
Published: May 2022

A novel tandem 1,6-addition/cyclopropanation/rearrangement reaction of vinylogous para-quinone methides with 3-chlorooxindoles has been developed, providing dispirooxindole–cyclopentane–cyclohexadienones with vicinal quaternary carbon centers.
Polyaniline/(Ta2O5–SnO2) hybrid nanocomposite for efficient room temperature CO gas sensing
Authors: Aranthady Chethana , Shanbhag Ganapati V. , Sundaram Nalini G.
Published: May 2022

Room temperature CO sensing using a hybrid (Ta2O5–SnO2) : PANI composite material.
Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety
Authors: Ohta Kaito , Fushimi Tetsuya , Okamura Mutsumi , Akatsuka Akinobu , Dan Shingo , Iwasaki Hiroki , Yamashita Masayuki , Kojima Naoto
Published: May 2022

The in vivo active 1-methylpyrazole-5-sulfonamide analog of acetogenins was obtained by the structure–antitumor activity relationship, focusing on the connecting groups between the heterocycle and the linker.
Fabrication of microfluidic chips using laser click deposition
Authors: Lv Mengqi , He Xinyu , Zhou Kai , Niu Ben , Wei Wei , Li Haoran , Liu Shasha , Su Hua , Wang Wei
Published: May 2022

A programmable and low-cost laser click deposition method is proposed to form complicated patterns as master molds for microfluidic chips.
Synthesis of quantum dot-based polymer nanocomposites: assessment of their thermoelectric performances
Authors: Shisodia Shivani , Duponchel Benoit , Leroy Gérard , Hadj Sahraoui Abdelhak , Singh Dharmendra Pratap , Poupin Christophe , Tidahy Lucette , Cousin Renaud , Ropa Patrick , Depriester Michael
Published: May 2022

Inhomogeneity and the presence of strong grain boundaries are responsible for the potential energy-filtering effect in the bulk state of PEDOT:PSS nanocomposites, which increases the Seebeck coefficient and electrical conductivity simultaneously.
Nickel–cobalt bimetallic tungstate decorated 3D hierarchical porous carbon derived from lignin for high-performance supercapacitor applications
Authors: Shi Feiyan , Zhao Shuai , Yang Junyu , Tong Yao , Li Jiajun , Zhai Shangru , Zhao Xinyu , Wu Shenghan , Li Hongsheng , An Qingda , Wang Kai
Published: May 2022

Transition-metal tungstates (MWO4), which are high-performance electrode materials for supercapacitor use thanks to their intrinsically outstanding electrochemical properties, have recently emerged and drawn great attention.
Promoting oxygen reduction via coordination environment modulation through secondary metal-atom incorporation
Authors: Yang Haozhou , Zhang Tianyu , Chi Xiao , Yu Xiaojiang , Chen Junmei , Chen Jiayi , Li Chunfeng , Tan Shengdong , He Qian , Wang Xun , Wang Lei
Published: May 2022

The incorporation of Cu single atoms into Fe-based single-atom catalysts (Fe-SACs) can regulate the coordination environment of Fe active sites and significantly enhance the oxygen reduction reaction (ORR) performance.
Calibrated gas accretion and orbital migration of protoplanets in 1D disc models
Authors: Schib O. , Mordasini C. , Helled R.
Published: May 2022

Context. Orbital migration and gas accretion are two interdependent key processes that govern the evolution of planets in protoplanetary discs. The final planetary properties such as masses and orbital periods strongly depend on the treatment of those two processes.

Aims. Our aim is to develop a simple prescription for migration and accretion in 1D disc models, calibrated with results of 3D hydro-dynamic simulations. Our focus lies on non-self-gravitating discs, but we also discuss to what degree our prescription could be applied when the discs are self-gravitating.

Methods. We studied migration using torque densities. Our model for the torque density is based on existing fitting formulas, which we subsequently modify to prevent premature gap-opening. At higher planetary masses, we also apply torque densities from hydrody-namic simulations directly to our 1D model. These torque densities allow us to model the orbital evolution of an initially low-mass planet that undergoes runaway-accretion to become a massive planet. The two-way exchange of angular momentum between disc and planet is included. This leads to a self-consistent treatment of gap formation that only relies on directly accessible disc parameters. We present a formula for Bondi and Hill gas accretion in the disc-limited regime. This formula is self-consistent in the sense that mass is removed from the disc in the location from where it is accreted. The prescription is appropriate when the planet is smaller than, comparable to, or larger than the disc scale height.

Results. We find that the resulting evolution in mass and semi-major axis in the 1D framework is in good agreement with those from 3D hydrodynamical simulations for a range of parameters.

Conclusions. Our prescription is valuable for simultaneously modelling migration and accretion in 1D models, which allows a planet’s evolution to be followed over the entire lifetime of a disc. It is applicable also in situations where the surface density is significantly disturbed by multiple gap-opening planets or processes like infall. We conclude that it is appropriate and beneficial to apply torque densities from hydrodynamic simulations in 1D models, at least in the parameter space we study here. More work is needed in order to determine whether our approach is also applicable in an even wider parameter space and in situations with more complex disc thermodynamics, or when the disc is self-gravitating.
Accurate Monitoring Technology of Core Body Temperature of "yunwentie" Human Body Based on TRIZ Theory
Authors: Yan QiuYi , Shen Tongyao , Yan Shuilian , Kuang Yinglu , Fan Dingxiu , lao Wenwen , Lan Xiaqi
Published: May 2022

Novel coronavirus pneumonia is a new type of core body temperature measurement product. Methods using TRIZ theory, the problems of existing temperature measurement methods in China were analyzed. Using the corresponding invention principle, solve the relevant problems of thermometer in clinical use, and put forward innovative solutions. Results according to the innovative design idea of TRIZ theory, it was applied to the new human core temperature measurement product. Novel coronavirus pneumonia is difficult to achieve the current core temperature monitoring of new crown pneumonia epidemic. Conclusion the application of TRIZ theory to the research and development of new human core thermometer products defines the improvement direction of thermometer, and puts forward a feasible scheme for the design and development of new human core thermometer products.
Development of E-commerce Strategic Transformation under the Background of the Internet
Authors: Cheng Jie
Published: May 2022

At the end of the 20th century, the rapid development of e-commerce has become a new growth point for China's economy. The entire e-commerce industry is in a thriving state. The Internet and electronics are gradually changing people's lives. The Internet continues to develop in China, and the concept of "Internet +" has been integrated and penetrated into all walks of life in China. Various technical means and the "Internet +" policy have further promoted the development of e-commerce at a faster speed. In the past two years, the competition among e-commerce companies has become increasingly fierce, and e-commerce companies have undergone transformation, but the effect is not significant, and there is still a certain gap between expectations. Internet technology can drive the transformation of e-commerce to a certain extent. Therefore, this article is mainly based on the development research of e-commerce ST (strategic transformation) under the background of the Internet. First, a comparative analysis of the status quo of several mainstream domestic e-commerce companies shows that the domestic e-commerce industry has great potential for development. Alibaba’s annual turnover is US$114.5 million, ranking first in the 2020 e-commerce transaction list. Secondly, it analyzes the effect of e-commerce ST under the background of the Internet. The results show that the rapid development of the Internet provides an excellent logistics system for the e-commerce industry, which helps e-commerce companies achieve differentiated and diversified development strategies.
Application of Information Technology in Chinese Language and Literature Teaching
Authors: Wang Jinping
Published: May 2022

The basic purpose of information technology is to promote, improve and support the teaching process. Language teaching technology is one of the products of communication and information technology in human science. It has a unique theoretical framework and principles. This technology is multidimensional and cross cutting. It is formed through the research on the theoretical and practical principles and basis of useful language level, computer language and knowledge of using the best technology. This paper discusses the problems existing in information technology teaching and information teaching environment, and finds that different types of teachers have different teaching methods.
The Value Embodiment and Realization of Art Education Function in Modern Society under the Background of Internet
Authors: Liang Jianhui
Published: May 2022

With the development and application of "Internet +", intelligent technology has been widely and deeply integrated into various fields, and has become an important driving force for social development. Under the background of the new Internet, art education and communication have formed a new form of "online and offline". Under the modern social scene, in order to give full play to the function of art education, we need to take the new social scene as the foundation, and reflect the value of the function of art education in modern society, put forward the concrete realization path of the function of art education.
Analysis on the Integrated Accounting System of Enterprise Accounting and Statistics in the Big Data Era
Authors: Liu Jun
Published: May 2022

In recent years, our country's comprehensive national strength has been continuously enhanced, the market economy system has been continuously improved, and the development of each industry has also undergone certain changes. The increasingly vigorous development of society and the increasingly fierce market competition are both opportunities and challenges for enterprises. If an enterprise wants to get better development, it is necessary to strengthen the management of its financial work. The current establishment of an integrated system of accounting and statistics is a good idea to improve the efficiency of corporate financial management and promote corporate development. Therefore, this article aims to study the integrated accounting system of enterprise accounting and statistics in the era of big data, and make full use of it on the basis of analyzing the status quo of our country’s economic information system, the reasons for this status, and the integration of accounting and statistic accounting. The advantages of big data technology have built a new economic information production system based on big data, organically combined accounting and statistical accounting, and tested the functions of the system. The test results show that, the functional test finally found no bugs, and the performance meets the current needs of users and choices.
The bonding mechanism and effects of sodium ligninsulfonate (SL) in iron ore pelletization
Authors: Zhou Jian-An , Wang Jun , Wang Bao , Ding Bin , Dang Yi-Chen , Li Yu-Jie
Published: May 2022

Bentonite is the most commonly used binder for iron ore pellets. However, due to its high alumina and silica content, the slag volume and energy consumption are increased. The aim of the present work is to identify the CSL (sodium ligninsulfonate added CaCO3) as an alternative binder in iron ore pelletization. FTIR and zeta potential tests verified that sodium ligninsulfonate (SL) reacted with magnetite mainly through ligand exchange, hydrogen bond and electrostatic interaction. Compared with SL, CSL has more active sites and stronger adsorbability. The strength of CSL preheated and roasted pellets was determined by TG and SEM. CaCO3 as a fluxing agent develops oxide bridging and bonding between the magnetite grains, forming more slag, reducing porosity and improving the compressive strength of roasted pellets. The experimental results show that it is feasible to add CaCO3 in SL as binder in pellet production.
Research and exploration of practical teaching based on the online-merge-offline
Authors: Liu Ping , Wu Min
Published: May 2022

Practical teaching is an indispensable and important part of teaching in higher vocational colleges. In view of the COVID-19 Era, teachers and students cannot carry out on-campus and offline teaching activities, which reduces the effect of practical teaching. In order to effectively carry out online practical teaching, the use of micro-video and simulation software through a variety of teaching platforms and online live broadcasts, “replacing reality with virtual reality”, increases the interaction between teachers and students, improves students’ participation, and achieves students. “The process of knowledge learning-knowledge internalization-knowledge solidification” solves the problem of insufficient hands-on ability in online teaching of practical courses.
Analysis of willingness and influencing factors of nursing undergraduates to engage in elderly service management
Authors: Chen Zheng , Shao Yangfeng
Published: May 2022

Under the background of population aging, the development of pension industry urgently needs colleges and universities to cultivate highlevel elderly service management talents. In this paper, 513 nursing undergraduates were investigated with self-made questionnaire. The results showed that the overall willingness of nursing undergraduates to engage in elderly service management was not high, and there was a significant difference in the willingness of nursing undergraduates with different demographic characteristics (P < 0.05). On the basis of in-depth analysis of influencing factors, the article holds that we should actively promote the cultivation of senior service management personnel at undergraduate level by guiding students to establish a sense of honor, enhancing their professional cognition of pension service, and reasonably positioning the training objectives to adapt to the professional development of nursing undergraduates.
How to promote student participation and improve online teaching
Authors: Song Min , Song Ying
Published: May 2022

By analysing the shortcomings of online teaching, this paper explores how to improve students’ participation and online teaching quality by improving information-based teaching equipment, teaching environment, teachers’ correct guidance, inspiration, good teaching methods, education mode and curriculum design.
Technology theme mining of integrated circuit manufacturing industry chain based on patents
Authors: Hu Kun , Zhang Yuntao , Ru Danyang , Wen Haoyu
Published: May 2022

Excavate and compare the technical themes of IC manufacturing industry chain of domestic and foreign patents, so as to objectively and comprehensively reveal the technical themes and differences of IC manufacturing in domestic and foreign, hoping to provide valuable reference for domestic IC manufacturing. Based on the integrated circuit manufacturing process, established the patent retrieval formula of each process and retrieved the patent data. Through TF-IDF algorithm and LDA model to mine the technical topics of domestic and foreign patents on the basis of self-built thesaurus and stop-words list, and summarized mining results. Through the analysis of results, it is found that the technical topics of integrated circuit manufacturing in domestic and foreign have similarities and differences, and the upper concept is strong, but the technical topics are more detailed of foreign patents.
Research on PBL teaching mode reform for the course of introduction to microelectronics
Authors: Xie Guangyong , Quan Pei
Published: May 2022

Problem-Based Learning (PBL) teaching mode is an effective teaching method for cultivating innovative talents. Based on the analysis of the teaching background of Introduction to Microelectronics and the PBL teaching mode, the course construction was planned and implemented in four aspects: the project topic selection of Problem-Based Learning, the course ideological education elements design, the material employment of science-technology cutting-edge and the construction of course assessment system. In addition, PBL teaching mode was designed the process of raising questions, exploring and solving questions, discussing and reporting and summarizing. The teaching design had been applied to practice and good teaching results had been obtained.
Teaching practice research of higher vocational course the inspection and repair of automobile comfort and safety system in moral education
Authors: Zhang Yan , Xu Miao , Deng Xiangzhou , Wei Yan , Han Yuyong
Published: May 2022

This article aims to study how to integrate the educational goal of cultivating talents through moral cultivation with the theoretical and practical teaching of the professional course. In order to realize a new teaching pattern of education, the study combined the professional course teaching with the ideological and political theory course teaching during the research process. Based on the practical teaching cases, this study followed the principle of combining qualitative and quantitative researches. The paper adopted several effective methods such as observation method, literature research method and case analysis method. It sums up the implementation approach of curriculum ideological and political construction strategy of “three integrations, two innovations and one connection”, so as to fulfill the fundamental task of establishing morality and cultivating talents.
Analysis of practice model for translation technology teaching based on artificial intelligence
Authors: Jiang Hua
Published: May 2022

This paper presents the development of artificial intelligence and the necessity of teaching reforms in the teaching of translation technology. By analyzing the teaching process in the first national translation technology teaching competition in 2021, it explores the classroom practice model of translation technology in China from four main dimensions -teaching philosophy, teaching content, teaching methods, and teaching evaluation. It then sheds light on some difficult points in the teaching technology model with the purpose of providing new insights for the teaching practice of translation technology.