bluuebunny/crossref_metadata_2025 huggingface dataset:
Status Quo in the Liposome-Based Therapeutic Strategies Against Glioblastoma: “Targeting the Tumor and Tumor Microenvironment”
Authors: Haseeb Mohd , Khan Imran , Kartal Zeynep , Mahfooz Sadaf , Hatiboglu Mustafa Aziz
Published: October 2024

Glioblastoma is the most aggressive and fatal brain cancer, characterized by a high growth rate, invasiveness, and treatment resistance. The presence of the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB) poses a challenging task for chemotherapeutics, resulting in low efficacy, bioavailability, and increased dose-associated side effects. Despite the rigorous treatment strategies, including surgical resection, radiotherapy, and adjuvant chemotherapy with temozolomide, overall survival remains poor. The failure of current chemotherapeutics and other treatment regimens in glioblastoma necessitates the development of new drug delivery methodologies to precisely and efficiently target glioblastoma. Nanoparticle-based drug delivery systems offer a better therapeutic option in glioblastoma, considering their small size, ease of diffusion, and ability to cross the BBB. Liposomes are a specific category of nanoparticles made up of fatty acids. Furthermore, liposomes can be surface-modified to target a particular receptor and are nontoxic. This review discusses various methods of liposome modification for active/directed targeting and various liposome-based therapeutic approaches in the delivery of current chemotherapeutic drugs and nucleic acids in targeting the glioblastoma and tumor microenvironment.
Differential Cytoprotective Effect of Resveratrol and Its Derivatives: Focus on Antioxidant and Autophagy-Inducing Effects
Authors: Varga Kamilla , Paszternák Alexandra , Kovács Virág , Guczogi Annamária , Sikur Noémi , Patakfalvi Dimitrisz , Bagaméry Fruzsina , Szökő Éva , Tábi Tamás
Published: October 2024

Numerous beneficial effects of resveratrol were reported; however, its pharmacological profile is contradictious. Previously, we have demonstrated that resveratrol has a dose-dependent cytoprotective effect and the essential role of autophagy induction was demonstrated. Resveratrol suffers from unfavorable pharmacokinetics, hindering its clinical use. Our aim was to study the cytoprotective effect of resveratrol derivatives to better understand structure–activity relationships that may facilitate the development of compounds with better druglike characteristics. Serum-deprivation-induced caspase activation, free radical generation, mitochondrial membrane depolarization and autophagy were detected in the presence of resveratrol analogs with different oxidation states on mouse embryonal fibroblasts. Distinct cytoprotective mechanisms of the examined compounds were revealed. Monomethyl resveratrol had similar potency to resveratrol (EC50: 85.3 vs. 84.2 μM); however, autophagy induction was not essential for its cytoprotective effect. Oxyresveratrol was found to be a strong antioxidant that can induce direct cytoprotection rather than autophagy. Trimethyl-resveratrol, lacking free hydroxyl groups, induced damage that was too significant and hardly compensated by the activation of cytoprotective machineries, and caspase activation was reduced by only 24.5%. Based on our results, methylation of resveratrol reduces its antioxidant activity, while autophagy induction can still contribute to its cytoprotective effect. The introduction of an additional hydroxyl group, however, augments the antioxidant properties, inducing cytoprotection without autophagy induction.
Autism Spectrum Disorder Pathogenesis—A Cross-Sectional Literature Review Emphasizing Molecular Aspects
Authors: Horecka-Lewitowicz Agata , Lewitowicz Wojciech , Wawszczak-Kasza Monika , Lim Hyebin , Lewitowicz Piotr
Published: October 2024

The etiology of autism spectrum disorder (ASD) has not yet been completely elucidated. Through time, multiple attempts have been made to uncover the causes of ASD. Different theories have been proposed, such as being caused by alterations in the gut–brain axis with an emphasis on gut dysbiosis, post-vaccine complications, and genetic or even autoimmune causes. In this review, we present data covering the main streams that focus on ASD etiology. Data collection occurred in many countries covering ethnically diverse subjects. Moreover, we aimed to show how the progress in genetic techniques influences the explanation of medical White Papers in the ASD area. There is no single evidence-based pathway that results in symptoms of ASD. Patient management has constantly only been symptomatic, and there is no ASD screening apart from symptom-based diagnosis and parent-mediated interventions. Multigene sequencing or epigenetic alterations hold promise in solving the disjointed molecular puzzle. Further research is needed, especially in the field of biogenetics and metabolomic aspects, because young children constitute the patient group most affected by ASD. In summary, to date, molecular research has confirmed multigene dysfunction as the causative factor of ASD, the multigene model with metabolomic influence would explain the heterogeneity in ASD, and it is proposed that ion channel dysfunction could play a core role in ASD pathogenesis.
Genome-Wide Analysis and Expression Profiling of Glyoxalase Gene Families Under Abiotic Stresses in Cucumber (Cucumis sativus L.)
Authors: Zhu Kaili , Zhang Yongxue , Shen Weiyao , Yu Lishu , Li Dandan , Zhang Haoyu , Miao Chen , Ding Xiaotao , Jiang Yuping
Published: October 2024

The glyoxalase pathway, consisting of glyoxalase I (GLYI) and glyoxalase II (GLYII), is an enzymatic system that converts cytotoxic methylglyoxal to non-toxic S-D-lactoylglutathione. Although the GLY gene family has been analyzed in Arabidopsis, rice, grape, cabbage, and soybean, cucumber studies are lacking. Here, we analyzed the cucumber GLY gene family, identifying 13 CsGLYI and 2 CsGLYII genes. Furthermore, we investigated the physicochemical properties, phylogenetic relationships, chromosomal localization and colinearity, gene structure, conserved motifs, cis-regulatory elements, and protein–protein interaction networks of the CsGLY family. They were primarily localized in the cytoplasm, chloroplasts, and mitochondria, with a minor presence in the nucleus. The classification of CsGLYI and CsGLYII genes into five classes closely resembled the homologous genes in Arabidopsis and soybean. Additionally, hormone-responsive elements dominated the promoter region of GLY genes, alongside light- and stress-responsive elements. The predicted interaction proteins of CsGLYIs and CsGLYIIs exerted a significant role in cellular respiration, amino acid synthesis, and metabolism, as well as methylglyoxal catabolism. In addition, the expression profiles of GLY genes were distinct in different tissues of cucumber as well as under diverse abiotic stresses. This study is conducive to the further exploration of the functional diversity among glyoxalase genes and the mechanisms of stress responses in cucumber.
Basal State Calibration of a Chemical Reaction Network Model for Autophagy
Authors: Hajdú Bence , Kapuy Orsolya , Nagy Tibor
Published: October 2024

The modulation of autophagy plays a dual role in tumor cells, with the potential to both promote and suppress tumor proliferation. In order to gain a deeper understanding of the nature of autophagy, we have developed a chemical reaction kinetic model of autophagy and apoptosis based on the mass action kinetic models that have been previously described in the literature. It is regrettable that the authors did not provide all of the information necessary to reconstruct their model, which made their simulation results irreproducible. In this study, based on an extensive literature review, we have identified concentrations for each species in the stress-free, homeostatic state. These ranges were randomly sampled to generate sets of initial concentrations, from which the simulations were run. In every case, abnormal behavior was observed, with apoptosis and autophagy being activated, even in the absence of stress. Consequently, the model failed to reproduce even the basal conditions. Detailed examination of the model revealed erroneous reactions, which were corrected. The influential kinetic parameters of the corrected model were identified and optimized using the Optima++ code. The model is now capable of simulating homeostatic states, and provides a suitable basis for further model development to describe cell response to various stresses.
A Missing Puzzle in Preclinical Studies—Are CCR2, CCR5, and Their Ligands’ Roles Similar in Obesity-Induced Hypersensitivity and Diabetic Neuropathy?—Evidence from Rodent Models and Clinical Studies
Authors: Bober Aleksandra , Mika Joanna , Piotrowska Anna
Published: October 2024

Research has shown that obesity is a low-grade inflammatory disease that is often associated with comorbidities, such as diabetes and chronic pain. Recent data have indicated that chemokines may play a role in these conditions due to their pronociceptive and chemotactic properties, which promote hypersensitivity and inflammation. Accumulating evidence suggests that CCR2, CCR5, and their ligands (CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11 CCL12, and/or CCL13) play a role in rodent models of pain and obesity, as well as in patients with diabetes and obesity. It was proven that the blockade of CCR2 and CCR5, including the simultaneous blockade of both receptors by dual antagonists, effectively reduces hypersensitivity to thermal and mechanical stimuli in chronic pain states, including diabetic neuropathy. The present review discusses these chemokine receptors and the role of their ligands in diabetes and obesity, as well as their involvement in diabetic neuropathy and obesity-induced hypersensitivity.
The Influence of Non-Dipping Pattern of Blood Pressure in Gestational Hypertension on Early Onset of Hypertension Later in Life—Single Center Experience in Very-High-Risk Southeast and Central European Country
Authors: Ilić Aleksandra , Stojšić-Milosavljević Anastazija , Miljković Tatjana , Bjelobrk Marija , Stojšić Snežana , Tadić Snežana , Stefanović Maja , Vulin Aleksandra , Preveden Andrej , Komazec Nikola , Čanković Milenko , Petrović Milovan , Ilić Djordje , Velicki Lazar , Kovačević Mila , Grković Dragana , Milovančev Aleksandra
Published: October 2024

Gestational hypertension (GH) and preeclampsia (PE) are associated with the onset of hypertension. This study aimed to investigate whether the blood pressure (BP) pattern in GH is associated with the prevalence of hypertension later in life. In this prospective cohort study pregnant women screened for GH underwent medical history, laboratory analysis, ambulatory blood pressure monitoring (AMBP), and transthoracic echocardiography (with left ventricular global longitudinal strain (LVGLS)) assessment. Overall, 138 GH (67 non-dippers and 71 dippers), 55 preeclamptic, and 72 normotensive pregnant controls were included. Women were followed in the postpartum period, first after 6 weeks and later on, for the occurrence of hypertension. The median follow-up was 8.97 years (8.23; 9.03). Non-dippers and PE compared with normotensives and dippers had a higher prevalence of hypertension onset (p < 0.01), as well as significantly reduced absolute values of LVGLS during pregnancy, after delivery, and at the time of onset of hypertension during follow-up (p < 0.01). Night-time diastolic BP, LVGLS, age, and left ventricular ejection fraction were the strongest predictors of postpartum onset of hypertension. The non-dipping BP pattern in GH was significantly associated with the onset of hypertension later in life, as well as with decreased systolic function.
Sexual Dimorphism in Impairment of Acetylcholine-Mediated Vasorelaxation in Zucker Diabetic Fatty (ZDF) Rat Aorta: A Monogenic Model of Obesity-Induced Type 2 Diabetes
Authors: Islam Rifat Ara , Han Xiaoyuan , Shaligram Sonali , Esfandiarei Mitra , Stallone John N. , Rahimian Roshanak
Published: October 2024

Several reports, including our previous studies, indicate that hyperglycemia and diabetes mellitus exert differential effects on vascular function in males and females. This study examines sex differences in the vascular effects of type 2 diabetes (T2D) in an established monogenic model of obesity-induced T2D, Zucker Diabetic Fatty (ZDF) rats. Acetylcholine (ACh) responses were assessed in phenylephrine pre-contracted rings before and after apocynin, a NADPH oxidase (NOX) inhibitor. The mRNA expressions of aortic endothelial NOS (eNOS), and key NOX isoforms were also measured. We demonstrated the following: (1) diabetes had contrasting effects on aortic vasorelaxation in ZDF rats, impairing relaxation to ACh in females while enhancing it in male ZDF rats; (2) inhibition of NOX, a major source of superoxide in vasculature, restored aortic vasorelaxation in female ZDF rats; and (3) eNOS and NOX4 mRNA expressions were elevated in female (but not male) ZDF rat aortas compared to their respective leans. This study highlights sexual dimorphism in ACh-mediated vasorelaxation in the aorta of ZDF rats, suggesting that superoxide may play a role in the impaired vasorelaxation observed in female ZDF rats.
The Degradation of Absorbable Surgical Threads in Body Fluids: Insights from Infrared Spectroscopy Studies
Authors: Merkel Katarzyna , Grzybowska Katarzyna , Strach Aleksandra , Gierek Marcin
Published: October 2024

This study investigates the degradation of six different types of absorbable surgical threads commonly used in clinical practice, focusing on their response to exposure to physiological fluids. The threads were subjected to hydrolytic and enzymatic degradation in physiological saline, bile, and pancreatic juice. Our findings demonstrate that bile and pancreatic juice, particularly when contaminated with bacterial strains such as Escherichia coli, Klebsiella spp., and Enterococcus faecalis, significantly accelerate the degradation process. Using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and tensile strength testing, we observed distinct differences in the chemical structure and mechanical integrity of the sutures. Principal component analysis (PCA) of the FTIR spectra revealed that PDS threads exhibited the highest resistance to degradation, maintaining their mechanical properties for a longer duration compared with Monocryl and Vicryl. These results highlight the critical role of thread selection in gastrointestinal surgeries, where prolonged exposure to bile and pancreatic juice can compromise the suture integrity and lead to postoperative complications. The insights gained from this study will contribute to improving the selection and application of absorbable threads in clinical settings.
An Information Gradient Approach to Optimizing Traffic Sensor Placement in Statewide Networks
Authors: Yang Yunxiang , Zhen Hao , Yang Jidong J.
Published: October 2024

Traffic sensors are vital to the development and operation of Intelligent Transportation Systems, providing essential data for traffic monitoring, management, and transportation infrastructure planning. However, optimizing the placement of these sensors, particularly across large and complex statewide highway networks, remains a challenging task. In this research, we presented a novel search algorithm designed to address this challenge by leveraging information gradients from K-nearest neighbors within an embedding space. Our method enabled more informed and strategic sensor placement under budget and resource constraints, enhancing overall network coverage and data quality. Additionally, we incorporated spatial kriging analysis, harnessing spatial correlations of existing sensors to refine and reduce the search space. Our proposed approach was tested against the widely used Genetic Algorithm, demonstrating superior efficiency in terms of convergence time and producing more effective solutions with reduced information loss.
The Effect of Climate Change on Indicator Wetland Insects: Predicting the Current and Future Distribution of Two Giant Water Bugs (Hemiptera: Belostomatidae) in South Korea
Authors: Kim Seon Yi , Lim Changseob , Kang Ji Hyoun , Bae Yeon Jae
Published: October 2024

Giant water bugs (Hemiptera: Belostomatidae) are top predators in wetland ecosystems, serving as biological indicators of the health of lentic ecosystems and as effective biological control agents for freshwater snails and mosquitoes. This study aimed to predict the current and future distribution of two Korean giant water bugs, Appasus japonicus and Diplonychus esakii, under three climate change scenarios, contributing to the sustainable management of wetland ecosystems in South Korea. Using MaxEnt models, we employed seven climatic and three non-climatic variables to investigate the habitat preferences and distribution patterns of the species. The results revealed that A. japonicus is likely to experience a northward range contraction due to climate change, while D. esakii is predicted to expand its distribution northward without losing its current range. These responses may lead to occupancy turnover between the two species, potentially driving reassembly in aquatic organism community. Elevation was the primary factor influencing the distribution of A. japonicus, whereas annual mean temperature was the most informative variable for D. esakii, both factors derived under the current climate conditions. These findings suggest that both species are highly sensitive to climate change, with potential range shifts toward higher latitudes and elevations. This study provides insights into how climate change could impact two giant water bugs, thereby supporting future efforts to manage and conserve wetland ecosystems in this country.
Modelling Blow Fly (Diptera: Calliphoridae) Spatiotemporal Species Richness and Total Abundance Across Land-Use Types
Authors: Laprise Madison A. , Grgicak-Mannion Alice , VanLaerhoven Sherah L.
Published: October 2024

Geographic Information Systems provide the means to explore the spatial distribution of insect species across various land-use types to understand their relationship with shared or overlapping spatiotemporal resources. Blow fly species richness and total fly abundance were correlated among six land-use types (residential, commercial, waste, woods, roads, and agricultural crop types) and distance to streams. To generate multivariate models of species richness and total fly abundance, blow fly trapping sites were chosen across the land-use gradient of Windsor–Essex County (Ontario, Canada) using a stratified random sampling approach. Sampling occurred in mid-June (spring), late August (summer), and late October (fall). Spring species richness correlated highest to residential (−), woods (−), distance to streams (+), and tomato fields (+) in models across all three land-use buffer scale distances (0.5, 1, 2 km), with waste (+/−), roads (−), wheat/corn (−), and commercial (−) correlating at only two of the three scales. Spring total fly abundance correlated with all but one land-use variable across all buffer scale distances, but the distance to streams (+), followed by orchards/vineyards (+) exhibited the greatest importance to these models. Summer blow fly species richness correlated with roads (−) and commercial (+) across all buffer distances, whereas at two of three buffer distances wheat/corn (−), residential (+), distance to streams (+), waste (−), and orchards/vineyards (+) were also important. Summer total fly abundance correlated to models with distance to streams (+), orchards/vineyards (+), and sugar beets/other vegetables (+) at the 2 km scale. Species richness and total abundance models at the 0.5 km buffer distance exhibited the highest correlation, lowest root mean square error, and similar prediction error to those derived at larger buffer distances. This study provides baseline methods and models for future validation and expansion of species-specific knowledge regarding adult blow fly relationships with spatiotemporal resources across land-use types and landscape features.
The Impact of Frailty and Surgical Risk on Health-Related Quality of Life After TAVI
Authors: van der Velden Kim E. H. M. , Spaetgens Bart P. A. , Buhre Wolfgang F. F. A. , Maesen Bart , de Korte-de Boer Dianne J. D. , van Kuijk Sander M. J. , van ‘t Hof Arnoud W. J. , Schreiber Jan U.
Published: October 2024

Symptomatic aortic stenosis and frailty reduce health-related quality of life (HrQoL). Transcatheter aortic valve implantation (TAVI) in patients at high to extreme risk has been proven to have a beneficial effect on HrQoL. Currently, TAVI is also considered in patients at intermediate risk. Our meta-analysis investigates whether benefits to HrQoL after TAVI is more pronounced in frail patients and patients at high to extreme vs. intermediate surgical risk. A systematic search of the literature was performed in November 2021 and updated in November 2023 in PUBMED, EMBASE, and the Cochrane Controlled Trials Register. Statistical analysis was performed according to the inverse variance method and the random effects model. A total of 951 studies were assessed, of which 19 studies were included. Meta-analysis showed a mean increase in the Kansas City Cardiomyopathy Questionnaire (KCCQ) score of 29.6 points (6.0, 33.1) in high to extreme risk patients versus 21.0 (20.9, 21.1) in intermediate risk patients (p < 0.00001) and 24.6 points (21.5, 27.8) in frail patients versus 26.8 (20.2, 33.4) in the general TAVI population (p = 0.55). However, qualitative analyses of non-randomized studies showed the opposite results. In conclusion, TAVI improves HrQoL more in high to extreme than intermediate risk patients. Frailty’s impact on HrQoL post-TAVI is inconclusive due to varying outcomes in RCTs vs. non-RCTs.
Secukinumab May Be an Effective Treatment Option for Axial Spondyloarthritis and Psoriatic Arthritis Patients with a History of Malignancy: Multicenter Real-Life Experience from Turkey
Authors: Ocak Tuğba , Yağız Burcu , Ocak Birol , Yoğurtçu Özge , Başıbüyük Fatma , Tezcan Dilek , Ermurat Selime , İnanç Elif , Yamancan Gülşah , Albayrak Fatih , Sağır Rabia Pişkin , Bayındır Akbaş Ayşe Nur , Cüre Osman , Coşkun Belkıs Nihan , Yolbaş Servet , Karasu Uğur , Kısacık Bünyamin , Koca Süleyman Serdar , Sarı İsmail , Akar Servet , Dalkılıç Ediz , Pehlivan Yavuz
Published: October 2024

Background: Secukinumab is a monoclonal antibody against interleukin 17 approved for patients with axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), and psoriasis. Treating axSpA and PsA patients with a history of malignancy is a challenge. While initial results on the applicability of secukinumab in this patient group are positive, the number of studies on this topic remains limited. This study aimed to investigate the drug’s survival time and the efficacy and safety of secukinumab treatment in this specific patient group. Methods: This retrospective study included 30 patients with a history of malignancy who were followed up in rheumatology outpatient clinics in 12 centers throughout Turkey and treated with secukinumab between May 2018 and March 2024 with a diagnosis of axSpA and PsA. Results: The mean follow-up time was 29.8 ± 19.3 months. The drug retention rate was 89.7% after 12 months and 80.6% after 24 months. The most common tumor in our study was papillary thyroid carcinoma (n = 5, 16.7%). During follow-up, local tumor recurrence was observed in a patient with urothelial carcinoma of the bladder. Conclusions: In the largest cohort reported to date, treatment with secukinumab in axSpA and PsA patients with a history of malignancy was not shown to cause oncologic recurrence except for one local tumor recurrence. Drug retention rates were also high, and disease activation and function improved compared to baseline. Therefore, secukinumab could be a safe and effective option for this patient group.
Contribution of Lab Radon Flux Measurements for Evaluating Submarine Groundwater Discharge in Coastal Areas
Authors: Bonotto Daniel M. , Nery José R. C. , Sabaris Tatiani P. P. , Mancini Luis H. , Lunardi Marina , Cigagna Cristiano , Fontanetti Lucas P. , Ceccato Gabrielle R.
Published: October 2024

Laboratory-scale experiments were conducted on Carboniferous Limestone gravels from the Mendip Hills area, England; sandstones from the Pirambóia and Botucatu formations, Paraná sedimentary basin, Brazil; samples of schist and quartzite from Caldas Novas Hydrothermal Complex, Brazil; and the minerals tantalite, cassiterite, and columbite from mining areas at Rio Grande do Norte State, Brazil, with the purpose of evaluating the release of 222Rn to the water phase. The specific surface area of the samples corresponded to 1.69–81.36 cm2g−1, which provided values of 0.001–1.68 dpm/g and 3.18 × 10−6 to 0.59 for the radon released and radon emanation coefficient, respectively. These results allowed us to calculate the radon flux with respect to the radon leakage, which corresponded to values of 0.00016–0.00158 Bq/m2/d for the denser materials and 0.018–0.43 Bq/m2/d for limestones and sandstones. They also permitted us to find an inverse, significant relationship between the radon generated by the minerals/rocks and the radon flux into the water phase, which was tested for sediments in coastal and inland Brazilian areas, demonstrating utility for evaluating the diffusive radon flux from the sediments, which is an important parameter to monitor submarine groundwater discharge (SGD) by means of radon as a natural tracer.
Underwater Gyros Denoising Net (UGDN): A Learning-Based Gyros Denoising Method for Underwater Navigation
Authors: Cao Chun , Wang Can , Zhao Shaoping , Tan Tingfeng , Zhao Liang , Zhang Feihu
Published: October 2024

Autonomous Underwater Vehicles (AUVs) are widely used for hydrological monitoring, underwater exploration, and geological surveys. However, AUVs face limitations in underwater navigation due to the high costs associated with Strapdown Inertial Navigation System (SINS) and Doppler Velocity Log (DVL), hindering the development of low-cost vehicles. Micro Electro Mechanical System Inertial Measurement Units (MEMS IMUs) are widely used in industry due to their low cost and can output acceleration and angular velocity, making them suitable as an Attitude Heading Reference System (AHRS) for low-cost vehicles. However, poorly calibrated MEMS IMUs provide an inaccurate angular velocity, leading to rapid drift in orientation. In underwater environments where AUVs cannot use GPS for position correction, this drift can have severe consequences. To address this issue, this paper proposes Underwater Gyros Denoising Net (UGDN), a method based on dilated convolutions and LSTM that learns and extracts the spatiotemporal features of IMU sequences to dynamically compensate for the gyroscope’s angular velocity measurements, reducing attitude and heading errors. In the experimental section of this paper, we deployed this method on a dataset collected from field trials and achieved significant results. The experimental results show that the accuracy of MEMS IMU data denoised by UGDN approaches that of fiber-optic SINS, and when integrated with DVL, it can serve as a low-cost underwater navigation solution.
External Moderation of Reactor Core Neutrons for Optimized Production of Ultra-Cold Neutrons
Authors: Medlin Graham , Korobkina Ekaterina , Teander Cole , Wehring Bernard , Sharapov Eduard , Hawari Ayman I. , Huffman Paul , Young Albert R. , Palmquist Grant , Morano Matthew , Hickman Clark , Rao Thomas , Golub Robert
Published: October 2024

The ultra-cold neutron (UCN) source being commissioned at North Carolina State University’s PULSTAR reactor is uniquely optimized for UCN production in the former graphite-filled thermal column outside of the reactor pool. The source utilizes a remote moderation design, which is particularly well suited to the PULSTAR reactor because of its high thermal and epithermal neutron leakage from the core face. This large non-equilibrium flux from the core is efficiently transported to the UCN source through the specially designed beam port in order to optimize UCN production at any given reactor power. The increased distance to the source from the core also greatly limits the heat load on the cryogenic system. A MCNP (Monte Carlo N-Particle) model of this system was developed and is in good agreement with gold foil activation measurements using a test configuration as well as with the real UCN source’s heavy water moderator. These results established a firm baseline for estimates of the cold neutron flux available for UCN production and prove that remote moderation in a thermal column port is a valuable option for future designs of cryogenic UCN sources.
Distributions of Lanostene-Derived Triterpenoids and Glucan Content in the Fruiting Bodies of the Australian Ganoderma Species
Authors: De Oliveira Campos Aline , Harrison Mark D. , Marshall David L. , Strong Peter James
Published: October 2024

Lanostene-derived triterpenoids and β-glucans are important metabolites in Ganoderma mushrooms associated with benefits to human health. The medicinal value of the Australian Ganoderma species remains unclear, with no data on triterpenoid distribution or glucan content. In the present study, 22 Australian Ganoderma specimens were analyzed for triterpenoid and glucan contents. Thirty-two triterpenoids were identified in the fruiting bodies of 19 of the specimens. Distinct patterns in triterpenoid distribution between laccate and matte fruiting bodies were observed, leading to the classification of four groups of Ganoderma. Most of the glucans in the Ganoderma fruiting bodies were β-glucans (~99%), with a nominal α-glucan content (~1%). The β-glucan content ranged from 19.5 to 43.5% (w/w). A range of antioxidant activities was observed for methanol extracts using the ABTS (1.8 to 8.4 mg GAE.g−1), DPPH (1.7 to 9.4 mg GAE/g−1) and FRAP (24.7 to 111.6 mmol FeSO4.g−1) assays, with four specimens presenting relatively high radical scavenging and reducing activities. For the first time, we demonstrated that Australian Ganoderma mushrooms contain medicinal triterpenoids, including ganoderic acid A, and we established a link between its distribution and the fruiting body morphology. However, further research is required to isolate diploid clones and determine factors that impact triterpenoid and glucan synthesis in these strains.
Overview of the Current Challenges in Pulmonary Coccidioidomycosis
Authors: Fayed Mohamed A. , Evans Timothy M. , Almasri Eyad , Bilello Kathryn L. , Libke Robert , Peterson Michael W.
Published: October 2024

Coccidioidomycosis is a disease caused by soil fungi of the genus Coccidioides, divided genetically into Coccidioides immitis (California isolates) and Coccidioides posadasii (isolates outside California). Coccidioidomycosis is transmitted through the inhalation of fungal spores, arthroconidia, which can cause disease in susceptible mammalian hosts, including humans. Coccidioidomycosis is endemic to the western part of the United States of America, including the central valley of California, Arizona, New Mexico, and parts of western Texas. Cases have been reported in other regions in different states, and endemic pockets are present in these states. The incidence of reported cases of coccidioidomycosis has notably increased since it became reportable in 1995. Clinically, the infection ranges from asymptomatic to fatal disease due to pneumonia or disseminated states. The recognition of coccidioidomycosis can be challenging, as it frequently mimics bacterial community-acquired pneumonia. The diagnosis of coccidioidomycosis is frequently dependent on serologic testing, the results of which can take several days or longer to obtain. Coccidioidomycosis continues to present challenges for clinicians, and suspected cases can be easily missed. The challenges of coccidioidomycosis disease, from presentation to diagnosis to treatment, remain a hurdle for clinicians, and further research is needed to address these challenges.
The Application of Rain Gardens in Urban Environments: A Bibliometric Review
Authors: Wang Mo , Zhuang Ji’an , Sun Chuanhao , Wang Lie , Zhang Menghan , Fan Chengliang , Li Jianjun
Published: October 2024

The increasing challenges of urbanization and climate change have driven the need for innovative stormwater management solutions. Rain gardens, as a nature-based solution (NBS), have emerged as a critical component in urban water management, particularly in enhancing hydrological regulation, water quality, and ecosystem services. This bibliometric review examines the application of rain gardens in urban environments, focusing on their roles in stormwater management, pollutant removal, and ecological enhancement. Data from 728 academic papers published between 2000 and 2023 were analyzed using the Web of Science (WoS) Core Collection, employing bibliometric tools such as the “Bibliometrix” R package and CiteSpace. The analysis highlights the increasing global interest in rain gardens, particularly since 2015, with China and the United States leading research efforts. Key findings reveal that rain gardens significantly reduce runoff, improve water quality, and contribute to urban biodiversity. In addition, their integration into public spaces offers landscape esthetics and social benefits, enhancing the quality of life in urban areas. However, challenges remain in optimizing their design for diverse climates and long-term performance. The study underscores the need for further research on plant–soil interactions, pollutant removal mechanisms, and the broader ecological and social contributions of rain gardens. This review provides insights into the evolution of rain garden research and identifies future directions for advancing sustainable urban stormwater management.
A Bibliometric Study of the Importance of Tourism in Salt Landscapes for the Sustainable Development of Rural Areas
Authors: Nistoreanu Puiu , Aluculesei Alina-Cerasela , Dumitrescu George-Cornel
Published: October 2024

Since ancient times, people have used salt for cooking and preserving food, its healing benefits, and as a means of payment. Therefore, the first settlements were located near water, food, and preferably salt, as prerequisites to further social and economic development. Naturally, the social development, the healing properties of salt, and the beauty of some salt landscapes have led to the development of tourism as an essential asset for rural communities. This paper aims to investigate the research focusing on the use of salt resources in tourism and to see if the exploitation of salt landscapes is an actual research topic linked to rural development. The study’s primary objectives are to investigate the scientific output in the tourism field, the main drivers in scientific production, and any connection between the importance of salt landscapes in tourism and sustainable rural development. The article represents a bibliometric analysis of 437 scientific articles published in prestigious journals indexed in the Web of Science until November 2023. The results emphasised a need for more research on using salt landscapes and resources in tourism as a central topic, as most identified studies focus on proposing models for the sustainable development of former salt mines and ecosystem restoration using tourism activity. Since many salt mining operations have been closed and the inhabitants of the neighbouring rural localities have been left without the related income, the results of this research are helpful for specialists in the field and for decision-makers to have a clear view of the development trends of areas rich in salt resources for tourism purposes.
Endangered Commons? Modeling the Effects of Demographic Trends Coupled with Admission Rules to Common Property Institutions
Authors: Dalla Torre Cristina , Scolozzi Rocco , Ravazzoli Elisa , Gatto Paola
Published: October 2024

This study investigates the long-term effects of demographic trends and admission rules on common properties in the Province of Trento, Italy, which we refer to as historical commons. Historical commons have evolved into socio-ecological systems over the centuries, meaning that communities governed collectively natural resources and lands essential for community survival. Communities and the admission rules that determine their composition are an important constituting element of historical commons because they have developed local ecological knowledge and practices of sustainable use of natural resources. Our study hypothesizes that commons continuity is endangered because of the declining trend of the size of communities being influenced by demographic trends coupled with admission rules. Grounding our research in systems dynamics, we use empirical data including demographic projections and existing admission rules to simulate their effect on the site of the community using the Province of Trento, Italy, as our study region. To achieve that, three types of historical commons are identified: open, semi-open, and closed, each with different admission criteria based on inheritance and/or residency. Results indicate that inheritance-based admission rules can significantly reduce the number of commoners over time, potentially endangering the continuity of these self-governance institutions. The study discusses the results in light of the literature on historical commons’ continuity to evaluate different policies affecting the size of the community grounding on different mental models. The study concludes that a simulation approach can promote an anticipatory approach to the co-design of policies to ensure inclusive continuity of historical commons.
Inflammatory and Lipid Biomarkers in Early Atherosclerosis: A Comprehensive Analysis
Authors: Namitokov Alim , Karabakhtsieva Karina , Malyarevskaya Olga
Published: October 2024

Introduction: Atherosclerosis is a leading cause of cardiovascular disease, characterized by lipid accumulation and chronic inflammation within arterial walls. Early detection in young adults is crucial for preventing adverse cardiovascular events. This study investigates the associations between inflammatory indices, lipid biomarkers, and the presence of atherosclerosis in patients aged 18 to 55 years. Methods: A cross-sectional study was conducted involving 89 participants divided into two groups: 62 patients with documented atherosclerosis (main group) and 27 healthy controls without significant atherosclerosis. Comprehensive data—including demographic information, medication use, imaging results, laboratory parameters, and calculated inflammatory indices (SIRI, SII, AISI, NLR, PLR, MLR)—were collected. Statistical analyses included correlation assessments, group comparisons using the Mann–Whitney U test, logistic regression modeling, feature importance analysis with Random Forest and Gradient Boosting classifiers, receiver operating characteristic (ROC) curves, and K-means clustering. Results: Significant differences were observed between the main and control groups. Patients with atherosclerosis exhibited elevated inflammatory indices (SIRI, NLR, MLR, SII) and lipid profile abnormalities (higher TC and LDL-C, lower HDL-C). Lp(a) and ANGPTL3 levels were significantly higher in the main group (p < 0.001 and p < 0.01, respectively). Logistic regression identified SIRI and ANGPTL3 as significant predictors of atherosclerosis, with the model demonstrating high accuracy (77%) and sensitivity (93%). Feature importance analysis confirmed the significance of SIRI and ANGPTL3, alongside traditional lipid biomarkers, in predicting disease presence. ROC analysis showed excellent model performance (AUC > 0.80). Clustering analysis revealed two distinct patient subgroups characterized by predominant inflammatory profiles or lipid metabolism disturbances. Conclusions: Systemic inflammation and lipid abnormalities play significant roles in early atherosclerosis among young adults. Elevated SIRI and ANGPTL3 levels are potent predictors of disease presence. The integration of inflammatory indices and lipid biomarkers into predictive models enhances risk stratification and supports personalized medicine approaches.
The HOMO-LUMO Gap as Discriminator of Biotic from Abiotic Chemistries
Authors: Abrosimov Roman , Moosmann Bernd
Published: October 2024

Low-molecular-mass organic chemicals are widely discussed as potential indicators of life in extraterrestrial habitats. However, demarcation lines between biotic chemicals and abiotic chemicals have been difficult to define. Here, we have analyzed the potential utility of the quantum chemical property, HOMO-LUMO gap (HLG), as a novel proxy variable of life, since a significant trend towards incrementally smaller HLGs has been described in the genetically encoded amino acids. The HLG is a zeroth-order predictor of chemical reactivity. Comparing a set of 134 abiotic organic molecules recovered from meteorites, with 570 microbial and plant secondary metabolites thought to be exclusively biotic, we found that the average HLG of biotic molecules was significantly narrower (−10.4 ± 0.9 eV versus −12.4 ± 1.6 eV), with an effect size of g = 1.87. Limitation to hydrophilic molecules (XlogP < 2) improved the separation of biotic from abiotic compounds (g = 2.52). The “hydrophilic reactivity” quadrant defined by |HLG| < 11.25 eV and XlogP < 2 was populated exclusively by 183 biotic compounds and 6 abiotic compounds, 5 of which were nucleobases. We conclude that hydrophilic molecules with small HLGs represent valuable indicators of biotic activity, and we discuss the evolutionary plausibility of this inference.
Green Sourcing: Supplier Assessment and Selection Practices across Industries
Authors: Adamides Emmanuel D. , Mouzakitis Yannis
Published: October 2024

Background: Over the last years, the assessment and selection of suppliers, based on the environmental performance of their products/services and their operations, has reached paramount importance and attracted the interest of many researchers and practitioners. Based on the prevailing perspective of supplier selection as a purely decision-making problem, this interest has been channeled towards the development of decision-support methods and tools. Other broader issues, such as whether there are converging or diverging green supplier evaluation and selection organizational processes across industries has not been addressed. Methods: Here, for the first time, we address this question by adopting a systems perspective and by considering green supplier evaluation and selection as an organizational sub-process of the broader sourcing process. We use activity theory to represent green supplier evaluation and selection as two interconnected activities, each comprising a set of organizational practices. Based on this representation, we developed a research instrument to carry out empirical research in a sample of 80 companies from five industries (pharmaceuticals, food processing, aquaculture, construction materials, waste management and recycling) in Greece. Results: The results of the survey suggest that green supplier evaluation and selection practices do not fully converge, but there are differences across industries. Conclusions: The cultural and historical context of industries influences the adoption of specific environmental supplier evaluation and selection practices.
Improving the Energy Storage Performance in Bi0.5Na0.5TiO3-Based Ceramics by Combining Relaxor and Antiferroelectric Properties
Authors: Pattipaka Srinivas , Lim Yeseul , Jeong Yundong , Peddigari Mahesh , Min Yuho , Jeong Jae Won , Jang Jongmoon , Kim Sung-Dae , Hwang Geon-Tae
Published: October 2024

Ceramic capacitors have received great attention for use in pulse power systems owing to their ultra-fast charge–discharge rate, good temperature stability, and excellent fatigue resistance. However, the low energy storage density and low breakdown strength (BDS) of ceramic capacitors limit the practical applications of energy storage technologies. In this work, we present a series of relaxor ferroelectric ceramics (1−x) [0.94 Bi0.5Na0.5TiO3 –0.06BaTiO3]– x Sr0.7Bi0.2TiO3 (1-x BNT-BT- x SBT; x = 0, 0.20, 0.225, 0.25, 0.275 and 0.30) with improved energy storage performances by combining relaxor and antiferroelectric properties. XRD, Raman spectra, and SEM characterizations of BNT-BT-SBT ceramics revealed a rhombohedral–tetragonal phase, highly dynamic polar nanoregions, and a reduction in grain size with a homogeneous and dense microstructure, respectively. A high dielectric constant of 1654 at 1 kHz and low remnant polarization of 1.39 µC/cm2 were obtained with the addition of SBT for x = 0.275; these are beneficial for improving energy storage performance. The diffuse phase transition of these ceramics displays relaxor behavior, which is improved with SBT and confirmed by modified the Curie–Weiss law. The combining relaxor and antiferroelectric properties with fine grain size by the incorporation of SBT enables an enhanced maximum polarization of a minimized P-E loop, leading to an improved BDS. As a result, a high recoverable energy density Wrec of 1.02 J/cm3 and a high energy efficiency η of 75.98% at 89 kV/cm were achieved for an optimum composition of 0.725 [0.94BNT-0.06BT]-0.275 SBT. These results demonstrate that BNT-based relaxor ferroelectric ceramics are good candidates for next-generation ceramic capacitors and offer a potential strategy for exploiting novel high-performance ceramic materials.
Performance Optimization of Alkaline Multi-Industrial Waste-Based Cementitious Materials for Soil Solidification
Authors: Wang Xiaoli , Wang Xiancong , Fu Pingfeng , Shi Jinjin , Xu Miao
Published: October 2024

This study presents the development of eco-friendly cementitious materials for soil stabilization, based on alkaline multi-industrial waste (AMIW), using steel slag (SS), blast furnace slag (BFS), carbide slag (CS), fly ash (FA) and flue gas desulfurization gypsum (FGDG) as the raw materials. The optimal AMIW-based cementitious material composition determined through orthogonal experiments was SS:CS:FGDG:BFS:FA = 15:10:15:44:16. Central composite design (CCD) in response surface methodology (RSM) was employed to optimize the curing process parameters. The maximum 7-day unconfined compressive strength (7d UCS) was achieved under the optimal conditions of 18.51% moisture content, 11.46% curing agent content and 26.48 min of mix-grinding time. The 7d UCS of the AMIW-stabilized soil showed a 24% improvement over ordinary Portland cement (OPC)-stabilized soil. Rietveld refinement results demonstrated that the main hydration products of the stabilized soil were C-S-H and ettringite. After curing for 7 days to 28 days, the C-S-H content increased from 3.31% to 5.76%, while the ettringite content increased from 1.41% to 3.54%. Mercury intrusion porosimetry (MIP) and scanning electron microscopy (SEM) analysis revealed that with the extension of curing time, the pores of the stabilized soil become smaller and the structure becomes denser, resulting in an improvement in compressive strength.
Low-Power Field-Deployable Interdigital Transducer-Based Scanning Laser Doppler Vibrometer for Wall-Thinning Detection in Plates
Authors: Kang To , Han Soonwoo , Yeom Yun-Taek , Lee Ho-Yong
Published: October 2024

Lamb waves have become a focal point in ultrasonic testing owing to their potential for long-range and inaccessible detection. However, accurately estimating the flaws in plates using Lamb waves remains challenging because of scattering, mode conversion, and dispersion effects. Recent advances in laser ultrasonic wave techniques have introduced innovative visualization methods that exploit the dispersion effect of Lamb waves to visualize defects via, for example, acoustic wavenumber spectroscopy. In this study, we developed an interdigital transducer (IDT)-based scanning laser Doppler vibrometer (SLDV) system without a power amplifier using a low-power IDT fabricated from lead magnesium niobate–lead zirconate titanate single crystals. To validate the proposed low-power IDT-based SLDV, four different defective plates were measured for defects. A comparison between a conventional IDT-based SLDV, a dry-coupled IDT-based SLDV, and the proposed method demonstrated that the latter is highly reliable for measuring thin plate defects.