bluuebunny/crossref_metadata_2025 huggingface dataset:
THE POSSIBILITIES OF COMPUTED TOMOGRAPHY IN DIAGNOSE OF THE STATE OF CORONARY ARTERIES IN PATIENTS WITH ISCHEMIC HEART DISEASE
Authors: Azizov V. A. , Sultanova M. J. , Uludag K. I. , Ephendieva L. G.
Published: August 2022

This research was aimed to study the possibilities of multislice computed (MSCT) tomography to diagnose status of coronary arteries at the patients with ischemic heart diseases. Material and methods. The research includes the results of complex study of 70 patients, which were send to the cardiology department for the verification of ischemic heart disease, as well as for examination and correction of provided therapy at this category. All patients had been provided traditional invasive coronary angiography and MSCT of coronary arteries. Results. At the 29 (76,3%) patients of 1 group stenosis of coronary arteries were not revealed, in 6 (15,8%) patients were revealed insignificant hemodynamic stenosis. In 3 (7,9%) patients revealed significant hemodynamic stenosis and in 1 (2,6%) critical stenosis (narrowing coronary artery lumen КА > 90 %). By data of MSCT and coronary angiography was revealed strong correlative relationship in diagnosis of stenosis. These factors argue about high comparability of both methods. The greatest correlation relationship was revealed for trunk of left coronary artery, right descending artery and circumflex artery and was 9,2; 0,84 and 0,81 accordingly. Analogical indexes were less for the right coronary artery and was 0,71. Though, large part of the patients in main group was not needed in intracoronary intervention and surgical revascularization. Conclusion. MSCT can use as noninvasive alternative method of coronary angiography in patients with high risk of ischemic heart disease. Comparative analysis of MSCT of coronary arteries and invasive coronary angiography revealed that MSCT has sensitivity of 91%, specificity of 89%.
CLINICAL CASE: COMBINATION THERAPY WITH BOSENTAN AND SILDENAFIL IN THE TREATMENT OF IDIOPATHIC PULMONARY HYPERTENSION
Authors: Bystrov V. V. , Arkhipova O. A. , Martynyuk T. V. , Saidova M. A. , Stukalova O. V. , Danilov N. M. , Sakhnova T. A. , Chazova I. Ye.
Published: August 2022

The patient with the verified diagnosis of idiopathic pulmonary hypertension, functional class III (WHO) was treated by anticoagulants, diuretics, calcium channel blocker. After one year of adding endothelin receptor antagonist bosentan there was noticed the negative dynamic with right heart chambers dilation, appearing of heart failure signs. By 11 months of the combined pathogenetic therapy with bosentan and phosphodiesterase type 5 inhibitor sildenafil there was achieved the significant improvement of the functional and hemodynamic status. This positive dynamics remained within the next 3 years of observation.
NATIONAL CLINICAL GUIDELINE ON DIAGNOSIS AND TREATMENT OF PULMONARY HYPRTENSION
Authors: Article Editorial
Published: August 2022

Developed on the instructions of the Russian Health Ministry, approved by the Society of Emergency Cardiology and the leading committee of Cardiology National clinical guidelines on diagnosis and treatment of pulmonary hypertension working group: Chair of working group - corresponding Member of the Russian Academy of Sciences, prof. Chazova I.Ye. (Moscow), deputy chair of working group - PhD Martynyuk T.V. (Moscow), prof. Avdeev S.N. (Moscow), PhD Volkov A.V. (Moscow), prof. Nakonechnikov S.N. (Moscow)
IEFFICACY OF INDAPAMIDE AND VALSARTAN COMBINED THERAPY PATIENTS WITH ARTERIAL HYPERTENSION AND METABOLIC DISORDERS
Authors: Khamidullaeva G. A. , Srojidinova N. Z. , Abdullaeva G. J. , Shakirova N. Sh. , Khafizova L. Sh.
Published: August 2022

Aim of the study: to study antihypertensive and organ-protective efficacy of indapamide and valsartan combined therapy hypertensive patients with high cardiovascular risk and metabolic disorders. Methods: The studyincluded 37 patients with stage I-III hypertension (ESH 2007), with an average age of 47.67±10.02 years, 48.6% men and 51.4% woman. Blood pressure was measured by Korotkov method. All patients were performed by M- and B-mode echocardiography. Flow-mediated endothelium dependent vasodilatation was measured during reactive hyperaemia due to 5 minute brachial occlusion.A 7.5 MHz highresolution ultrasound was used to measure carotid artery intimaemedia thickness (IMT). Blood lipid and glucose level, serum creatinin and uric acid level were estimated by enzyme assay method on biochemical analyzer “Daytona TM”. Results: 12-weekly combined therapy with indapamide and valsartan were shown very good antihypertensive efficacy in average daily doses 2.5 mg and 80±40.6 mg respectively, with reducing average blood pressure on 19.7±7.0% and attained goal level of BP in 92% cases. During the treatment were found significantly regress of left ventricular hypertrophy by reducing left ventricular mass index on 16.2±11.3%, effective vasoprotection, without significantly changes of metabolic disorders, which characterized indapamide and valsartan combination like metabolic neutral drug combination. Conclusion: Indapamide and valsartan combined therapy characterize with high antihypertensive, cardio- and vasoprotective efficacy andmetabolic neutrality choosing for treatment hypertensive patients with high cardiovascular risk and metabolic disorders.
Sharing is Caring & Giving is Winning
Authors: Abdul Gafoor Shafiah , Kandhari Navneet
Published: August 2022

The COVID-19 pandemic has been the defining health crisis of our generation. In the UK healthcare industry, where pre-pandemic surveys already demonstrated high levels of stress, it is imperative that actions are taken to support the mental wellbeing of staff from its expected psychological fallout. Feasible, low cost and time efficient interventions are warranted. Rewards-based incentives may carry promise.
Our group distributed 129 free wellbeing packages to junior doctors in a busy London Hospital. Open-ended and anonymised surveys were used to gather qualitative data on their effect. Data was analysed thematically and collated into 5 core themes: Emotional Response, Reaction to Initiative, Reaction to Product Choice, Gratitude and Feeling Valued.
Overall, the significant majority of respondents (n=50, 96%) were highly appreciative of the intervention, deeming it both useful and relevant to supporting their mental health. This study bears useful findings for other organisations looking to implement similar low-cost wellbeing strategies.
Measuring Elemental Abundances of JWST Target Stars for Exoplanet Characterization. I. FGK Stars
Authors: Kolecki Jared R. , Wang 王 Ji 吉
Published: August 2022

With the launch of the JWST, we will obtain more precise data for exoplanets than ever before. However, these data can only inform and revolutionize our understanding of exoplanets when placed in the larger context of planet–star formation. Therefore, gaining a deeper understanding of their host stars is equally important and synergistic with the upcoming JWST data. We present detailed chemical abundance profiles of 17 FGK stars that will be observed in exoplanet-focused Cycle 1 JWST observer programs. The elements analyzed (C, N, O, Na, Mg, Si, S, K, and Fe) were specifically chosen as being informative to the composition and formation of planets. Using archival high-resolution spectra from a variety of sources, we perform an LTE equivalent width analysis to derive these abundances. We look to literature sources to correct the abundances for non-LTE effects, especially for O, S, and K, where the corrections are large (often >0.2 dex). With these abundances and the ratios thereof, we will begin to paint clearer pictures of the planetary systems analyzed by this work. With our analysis, we can gain insight into the composition and extent of migration of Hot Jupiters, as well as the possibility of carbon-rich terrestrial worlds.
The Serological Examination of Immunoglobulin A Anti-Early Antigen of Epstein–Barr Virus (Anti-EA EBV IgA) in the Nias Tribe Nasopharyngeal Cancer Patients
Authors: Ginting Hana Isal Salina , Farhat Farhat , Sari Mutiara Indah
Published: August 2022

BACKGROUND: Nasopharyngeal cancer (NPC) is a health problem associated with malignancies of the ear, nose, and throat. The main pathogenesis of NPC is Epstein–Barr virus (EBV) infection. The signs and symptoms of NPC are non-specific, causing the occurrence of delay in diagnosis leading to treatment failure. The early detection based on the NPC profile using immunoglobulin A (IgA) antibodies against the early antigen (EA) can be done, but many factors affect anti-EA EBV IgA levels, one of which is ethnicity.

AIM: This study aimed to compare levels of anti-EA EBV IgA in NPC patients and non-NPC in the Nias tribe.

MATERIALS AND METHODS: This study was cross-sectional involving 29 NPC patients and 29 non-NPC in the Nias tribe. The subjects of the study were blood tests to measure the levels of anti-EA EBV IgA by a serological test. Data were analyzed by Chi-square test.

RESULTS: The results showed that the mean value of anti-EA EBV IgA levels is 246.22 ± 320.05 U/mL and the proportion of positive serology tests is 55.2% in NPC patients. The mean value of anti-EA EBV IgA levels is 51.79 ± 1.55 U/mL and the proportion of positive serology tests is 10.3% in non-NPC. The comparison of mean anti-EA EBV IgA between NPC patients and non-NPC was significant (p < 0.001). The comparison of positive and negative serology tests of anti-EA EBV IgA between NPC patients and non-NPC was significant (p < 0.05).

CONCLUSION: The serology tests of anti-EA EBV IgA play a role in differentiating NPC patients from non-NPC, so it can be useful as a screening tool for NPC in the Nias tribe.
The Association between Lower Uterine Segment Involvement in Corpus Located Endometrioid Adenocarcinoma with the (International Federation of Gynecology and Obstetrics) Grade and Stage
Authors: Hasan Farah , Hussein Zina
Published: August 2022

BACKGROUND: Although lower uterine segment (LUS) is regarded as an anatomically defined part that possess some histological differences, it is involvement by carcinoma have not been included in the criteria for definition in the staging system for endometrial carcinoma and there are few conflicting data focused on the effect of LUS involvement as a prognostic factor in endometrial cancer.

AIM: To find the association between LUS involvement in corpus located endometrioid carcinoma with the grading and staging system established by the international federation of gynecology and obstetrics (FIGO).

METHODS: This was a retrospective study involving data collected from achieves of histopathology departments of teaching laboratories within successive 4 years period in Medical City complex at Bagdad. Pathological analysis of 70 hysterectomy specimens of corpus located endometriod adenocarcinoma was done, histological sections from each case of endometrioid adenocarcinoma carcinoma were microscopically reviewed for appropriate grading and staging, in addition, meticulous search was applied for histological finding consistent with LUS involvement. The statistical comparison between the results was done using either independent sample t-test (for continuous data; mean ± SD) or Chi-square test at a significant p < 0.05.

RESULTS: The study enrolled 70 histological samples of endometrioid adenocarcinoma, the majority of the samples were of low grade and stage at presentation. Of total sample, 46 (65.71%) showed LUS involvement by tumor cells. There was a significant statistical relationship between LUS involvement and FIGO stage while a non-significant statistical association with FIGO grade was found.

CONCLUSION: LUS involvement by corpus located endometrioid adenocarcinoma is associated with an advanced FIGO stage at presentation while non-significant relationship was found between patient age and tumor grade.
Mindful and Positive leadership Interventions: the impacts on positive experiences, traits, and behaviors
Authors: Giraud Laurent , Frimousse Soufyane , Le Bihan Yves
Published: August 2022

Le présent article étudie les effets d’une intervention en leadership positif et pleine conscience sur les expériences, les traits et les comportements positifs des managers et de leurs salariés. Notre méthodologie de recherche repose sur une quasi-expérimentation avec des prétests et post-tests aléatoires effectués sur un groupe de contrôle spécifique : dans une entreprise pharmaceutique française, un groupe de 36 managers a participé à une intervention en psychologie positive (PPI) de 10 jours axée sur le leadership positif et la pleine conscience. Les données recueillies avant (T1) et après (T2) l’intervention montrent que les expériences et les comportements positifs ont augmenté, tandis que les traits positifs ont été renforcés chez les participants – mais pas parmi les membres du groupe de contrôle. Ces observations ont été recoupées avec les données recueillies au niveau des salariés. Plus précisément, les résultats indiquent qu’après l’intervention (T2), les managers ont ressenti plus d’empathie, de pleine conscience et de consonance tout en ressentant moins de stress. De même, à T2, les salariés ont confirmé que leurs managers ayant pris part à l’intervention étaient plus attentifs et affichaient une plus grande conscience collective. De plus, ces salariés ont perçu que leurs managers sensibilisés à la psychologie positive et à la pleine conscience faisaient preuve de davantage de justice procédurale et de vertus civiques organisationnelles. Les contributions théoriques, empiriques et managériales de cette étude sont également discutées.
The Riemann-Liouville fractional integral in Bochner-Lebesgue spaces I
Authors: Neto Paulo Mendes de Carvalho , Júnior Renato Fehlberg
Published: August 2022

In this paper we study the Riemann-Liouville fractional integral of order \begin{document}$ \alpha>0 $\end{document} as a linear operator from \begin{document}$ L^p(I,X) $\end{document} into itself, when \begin{document}$ 1\leq p\leq \infty $\end{document}, \begin{document}$ I=[t_0,t_1] $\end{document} (or \begin{document}$ I=[t_0,\infty) $\end{document}) and \begin{document}$ X $\end{document} is a Banach space. In particular, when \begin{document}$ I=[t_0,t_1] $\end{document}, we obtain necessary and sufficient conditions to ensure its compactness. We also prove that Riemann-Liouville fractional integral defines a \begin{document}$ C_0- $\end{document}semigroup but does not defines a uniformly continuous semigroup. We close this study by presenting lower and higher bounds to the norm of this operator.
Mathematical modeling of SARS-nCoV-2 virus in Tamil Nadu, South India
Authors: Shankaranarayanan Avinash , Wei Hsiu-Chuan
Published: August 2022

The purpose of this paper is to build a mathematical model for the study of the roles of lock-down, social distancing, vaccination, detection efficiency, and health care capacity planning of the COVID-19 pandemic taking into account the demographic topology of the State of Tamil Nadu, India. Two mathematical models are proposed for the evolution of the first and second wave of COVID-19 pandemic. The model for the first wave considers lock-down orders, social distancing measures, and detection efficiency. The model for the second wave considers more sub-populations and incorporates two more elements, vaccination and health care capacity. Daily reported data on the evolution of the COVID-19 pandemic are used to determine the parameter values. The dynamics produced by the mathematical model closely follow the evolution of COVID-19 in the State of Tamil Nadu. Numerical simulation shows that the lock-down effect is limited. Social distancing implementation and detection of positive cases are relatively ineffective compared with other big cities. Shortage of health care resources is one of the factors responsible for rapidly spreading in the second wave in Tamil Nadu.
Prescribed-time control of stochastic high-order nonlinear systems
Authors: Wang Hui
Published: August 2022

In this paper, the prescribed-time stabilization is studied for stochastic high-order nonlinear systems. Different from the previous research results on stochastic high-order nonlinear systems where only asymptotic stabilization or finite-time stabilization is considered, this paper proposes a new design to achieve stabilization in the prescribed-time. Specifically, the designed controller can ensure that the closed-loop system has an almost surely unique strong solution and the equilibrium of the closed-loop system is prescribed-time mean-square stable. The design method is verified by an example.
Global Localities of Game Production
Authors: Young Chris J. , Reed Emilie , Keogh Brendan
Published: August 2022

Accounts of digital game production are increasingly at the forefront of how we document and theorize conditions and transformations of how cultural media are produced, regulated, distributed, marketed, and consumed. These accounts have typically examined games as a global industry that coexists with and contributes to the formation of national industries, including publisher and studio formations, geopolitics, tax breaks and credits, regional regulatory frameworks, and cultural sovereignty. This introduction to the special issue “Local Game Production” reasserts the analytical value in using locality as an entry point for the study of digital game production. The special issue offers four articles that confront economic, labour, and technical formations in game production, and expose the encounters of localities with globalization. These articles reveal why considerations of the local are critical in understanding the wider infrastructures, governance frameworks, and economies that shape the production of culture through global games. Each article underscores the inequities in how game production localities leverage power via platforms, nation-states and economic regions, and predominant cultural activities.
El Comité de los Derechos del Niño como nueva plataforma del derecho internacional ambiental (análisis del dictamen Sacchi y otros vs. Argentina y otros)
Authors: Ravetllat Balleste Isaac , Lucero P. Jairo E.
Published: August 2022

En ocasión a la Comunicación del 23 de septiembre de 2019 en la que 16 niños, niñas y adolescentes de diferentes nacionalidades hicieron uso del Tercer Protocolo Facultativo de la Convención sobre los Derechos del Niño, relativo a un procedimiento de comunicaciones, alegando el incumplimiento de los compromisos asumidos frente al cambio climático por parte de cinco Estados (Sacchi y otros vs. Argentina, Brasil, Francia, Alemania y Turquía), el pasado 22 de septiembre de 2021 el Comité de los Derechos del Niño emitió 5 dictámenes dando respuesta a los mentados requerimientos. En todos ellos, el Comité ginebrino se inclinó por la inadmisibilidad de los mismos debido a la falta de agotamiento de recursos internos. Esta postura, si bien implicó un grave retroceso a la exigibilidad de las obligaciones climáticas producto, entre otras, de la falencia del Tercer Protocolo Facultativo como proceso que permita la recepción de comunicaciones relativas a vulneraciones de derechos supraindividuales, también implicó grandes avances frente a la conceptualización de la noción jurisdicción y condición de víctima en casos de responsabilidad ambiental extraterritorial. En tal sentido, el presente artículo, haciendo uso de una investigación descriptiva y explicativa, empleando la metodología dogmática y del enjuiciamiento de hecho, analiza, en primer término, los dictámenes resueltos por el Comité en clave tanto de los progresos como de las oportunidades perdidas para que el procedimiento de comunicaciones se erija como una nueva plataforma de litigio climático, y, a continuación, se señalan las necesarias transformaciones que debieran introducirse en tal procedimiento seguido ante el Comité de los Derechos del Niño para alcanzar lo que podríamos denominar como verdadera justicia climática.
Digital Ethnography Divide and Blended Learning Practices
Authors: Nehal Raashid , Sulaiman Zain Mohammad , Husain Saddam
Published: August 2022

The COVID-19 complications have again put the scale and scope of digital communication methodology and classroom instruction in a divide. Unfortunately, norm-referenced assessments have not produced the desired results since there is a huge gap between learning and assessment. Blended learning and alternative assessment provide greater access to redirect learners for better learning outcomes. The chapter seeks to explore the challenges of digital ethnography with reference to blended learning practices.
Shame on You!
Authors: Lozano Rodriguez Manuel
Published: August 2022

This chapter is a philosophical essay on how digital ethnography can shed light upon digital hate (especially homicidal hate) and self-harm. The author will do it by attending to the planned (ex)termination of a physical and social individual by herself or by the few ones' havoc against the rest of the people. Likewise, the author will meditate on the reality of lobbies and parties' silent wars and liberticide from different perspectives (post-structuralist, feminist, etc.) to attain a plural view on it while observing the role of digital ethnography in societies ranging from Indonesia to Spain. Therefore, it's an original study that embraces a unique scope of the unwilling ending of human existence and personas from a different and non-politicised angle.
Digital Appreciative Inquiry for Inclusion
Authors: Morgan Ann M. , Pelletier Kathe
Published: August 2022

Appreciative inquiry is an approach with the power to contribute to inclusion in the workplace. Paired with digital interventions, which share the power to include and the potential to exclude, digital appreciative inquiry offers promising possibilities when used with intention. This chapter presents guidance to help higher education institutions accomplish the goals of inclusion using digital appreciative inquiry, which can lead to greater staff and faculty belonging, trust, engagement, and institutional sustainability.
Sustainable Strategic Planning for Inclusive Online Teaching and Learning
Authors: Subocz Sue , Chumley Heidi , Banerjee Sri , Cano-Wolfbrandt Myrna
Published: August 2022

It may indeed be time to stop strategic planning, at least as it has most typically been considered and conducted, in favor of approaches that focus on articulating visions for a future built on the individual and collective experiences of learners and future learners of an institution. Instead, it may be time to create operational plans designed to sustain a culture of community commitment and ensure an inclusive teaching and learning environment. Such an inclusive teaching and learning environment is founded on (1) an understanding of learners as whole people with pasts that must be honored throughout the learning process, (2) a set of complex social circumstances that must be considered in the design and delivery of learning experiences, and (3) a future that is unpredictable and ever-changing.
A Study to Analyse the Impact of Using the Metaverse in the Banking Industry to Augment Performance in a Competitive Environment
Authors: Seth Dinesh , Gupta Meenu , Singh Bikram Jit
Published: August 2022

The metaverse is set to disrupt the banking and financial industry in an effective manner. The application of virtual reality and augmented reality offers innovative experience to the customers, which will create opportunities in the banking domain. The collaboration of VR and MR creates critical digital contact with real-world experience and support in augmenting the services in an effective manner. This will enable in creating rich experience and seen as the motive for many opportunities in the industry. The integration between AI and 5G will support the metaverse in enhancing the growth potential for better advantage and offering enhanced solutions. The study is focused on using the quantitative research tools for performing the analysis. The researchers focus on collecting information through survey method. Various closed ended questions are framed for understanding the responses of the sample population who are currently working in the banking industry.
Does Knowledge Really Help?
Authors: Lin Boqiang , Yang Mengqi
Published: August 2022

Drawing on the self-determination theory, this study explored the effect of three kinds of low-carbon knowledge (LCB), including system knowledge (SK), action-related knowledge (AK), and effectiveness knowledge (EK), on college students’ low-carbon behavior (LCB) by focusing on the mediating role of low-carbon intrinsic motivation (LCIM) and the moderating role of climate change risk perception (CCRP). Using a sample of 2846 college students in China, this study found that SK has an inverted U-shaped relationship with LCB, but AK and EK positively affect LCB. Moreover, LCIM mediates the relationship between three kinds of LCK and LCB. The moderated path analysis also indicated that CCRP could strengthen the impact of LCB on LCIM. Finally, this study discusses the theoretical significance of these findings and provides some policy suggestions and practical implications for the government.
Molecular Docking Study for Prediction of Chiral HPLC Separation of Hydroxychloroquine as an Alternative Antiviral of SARS-CoV-2
Authors: Moneteringtyas Prisca Caesa , Kuncaka Agus , Hermawan Dadan , Mudasir Mudasir
Published: August 2022

The HPLC chiral separation of hydroxychloroquine (HCQ) using chiral α-1-acid glycoprotein (AGP) column has been predicted based on a molecular docking approach. The research begins with the geometrical optimization of the HCQ compound using the quantum calculation method of semiempirical (SE) of PM6, AM1, and PM3, and Hartree-Fock (HF) and density functional theory (DFT/B3LYP) with the basis set of 3-21G, 6-31G, and 6-311G. Molecular docking was performed with AutoDock Vina and PyRx applications on exhaustiveness of 264. Redocking with AutoDock Vina was done using coordinates of X = 13.584; Y = 1.47; Z = 18.451 with a grid box size of 40 x 40 x 40 and a grid Spacing of 0.375 Å, followed by specific docking process using the same conditions as redocking. The DFT method with the basis set of 6-311G was the best calculation method because it gives the lowest PRESS and closest r2 value to one for the comparison between calculated and experimental data of 1H-NMR. The docking result shows that R-HCQ enantiomer has more negative value of binding energy and more diverse interactions in the inclusion complex, indicating that R-HCQ forms more stable complex with AGP, and therefore it will be retained longer in the AGP column and eluted from the column later after R-HCQ.
Hospital length of stay for COVID-19 patients: A systematic review and meta-analysis
Authors: Alimohamadi Yousef , Mansouri Yekta Elahe , Sepandi Mojtaba , Sharafoddin Maedeh , Arshadi Maedeh , Hesari Elahe
Published: August 2022

The length of stay in the hospital for COVID-19 can aid in understanding the disease's prognosis. Thus, the goal of this study was to collectively estimate the hospital length of stay (LoS) in COVID-19 hospitalized individuals. To locate related studies, international databases (including Google Scholar, Science Direct, PubMed, and Scopus) were searched. The I2 index, the Cochran Q test, and T2 were used to analyze study heterogeneity. The mean LoS in COVID-19 hospitalized patients was estimated using a random-effects model. COVID-19's total pooled estimated hospital LoS was 15.35, 95%CI:13.47-17.23; p<0.001, I2 = 80.0). South America had the highest pooled estimated hospital LoS of COVID-19 among the continents, at 20.85 (95%CI: 14.80-26.91; p<0.001, I2 = 0.01), whereas Africa had the lowest at 8.56 8 (95%CI: 1.00-22.76). The >60 age group had the highest pooled estimated COVID-19 hospital LoS of 16.60 (95%CI: 12.94-20.25; p<0.001, I2 = 82.6), while the 40 age group had the lowest hospital LoS of 10.15 (95% CI: 4.90-15.39, p<0.001, I2 = 22.1). The metanalysis revealed that COVID-19's hospital LoS was more than 10 days. However, it appears that this duration varies depending on a number of factors, including the patient's age and the availability of resources.
Smartphone Use among Anesthesiologists during Work Hours
Authors: Ambasta Suruchi , Kannaujia Ashish Kumar , Shamshery Chetna , Shrivastava Divya , Mishra Prabhakar , Mahapatra Swagat
Published: August 2022

Context:

Smartphone use has revolutionized life in all spheres, including the medical field. Smartphones provide immense opportunities but may also lead to negative consequences due to the element of distraction. In the medical profession and more so among anesthesiologists, multitasking has become very common, but the presence of mind is equally important. This study attempts to analyze the smartphone practices and trends among anesthesiologists during work hours in our country.

Aims:

The study aimed to identify recent trends and practices of smartphone use among anesthesiologists during working hours and its distribution as per designation and institutions. It also intends to determine the purposes of smartphones and their impact on patient care.

Settings and Design:

Online survey consisting of open-ended multiple-choice questions was conducted and circulated as Google Forms via E-mail and WhatsApp.

Subjects and Methods:

This survey was conducted to compare the respondents' views as per designation and workplace distribution. In addition, participants were asked about the current practices in smartphone use at their workplace, purposes of use, time spent on smartphones, and any negative medical consequences faced due to the same.

Statistical Analysis Used:

One-way ANOVA test was used to compare the means between the groups. Chi-square test/Fisher's exact test was used to compare the proportions.

Results:

Two hundred and sixteen (54%) were resident doctors, whereas 184 (46%) were consultants. Most of the respondents were young, with a mean age around 36 years. 31.5% of the residents used smartphones very often during anesthetized patient care compared to 10.3% of the consultants. Purposes of using smartphones were multiple, with phone calls (100%) being the most common followed by WhatsApp messaging (79.2%). 86.1% of the residents, as compared to 61% of the consultants, had anesthesia/intensive care unit-related apps on their smartphones. There was almost an equivocal response to how the smartphone has impacted patient care. 50.9% of the residents and 43% of the consultants felt improved patient care, whereas 38% of the residents and 43.5% of the consultants believed it had worsened.

Conclusion:

There was no clear-cut consensus whether smartphone use improved or worsened patient care. On the one hand, there can be distractions leading to adverse medical consequences, while on the other hand, the use of medical apps has been made possible because of the handy and easily accessible smartphones. Thus, the use of smartphones may be carried out with a sense of responsibility by the anesthesiologists during work hours.
Effect of Dexmedetomidine in Sub-Tenon's Block on Emergence Agitation in Pediatric Strabismus Surgery under Sevoflurane Anesthesia
Authors: El-Sherbiny Sameh M. , Kamal Ragab A. , Sadik Nashwa , Elshahat Ahmed
Published: August 2022

Background:

Numerous unfavorable complications may occur with strabismus surgery as emergency agitation (EA), oculocardiac reflex (OCR), postoperative pain, and postoperative nausea and vomiting (PONV).

Aims:

This study was designed to evaluate the dexmedetomidine effect in sub-Tenon's block on EA in strabismus surgery in the pediatric population under sevoflurane anesthesia.

Design:

This was a prospective randomized double-blind clinical trial.

Patients and Methods:

Eighty American Society of Anesthesiologists (ASA) Physical Status Class I and II pediatric patients, in an age group ranging from 2 to 8 years of either sex, had strabismus surgery under sevoflurane anesthesia using laryngeal mask airway. Patients were divided randomly into two groups (each = 40). Sub-Tenon's block is performed in the operated eye with 0.5% bupivacaine (0.08 mL.kg−1) alone in Group B (bupivacaine group), and with 0.5% bupivacaine (0.08 mL.kg−1) and dexmedetomidine (0.5 μg.kg−1) in Group D (dexmedetomidine group). Hemodynamics were monitored, and OCR was recorded. Furthermore, postoperative EA (Pediatric Anesthesia Emergence Delirium and Cravero Scales), pain (Face, Legs, Activity, Cry, and Consolability), and incidence of PONV were recorded as well.

Statistical Analysis:

A prospective analysis of the collected data was performed using the SPSS program for Windows (version 26).

Results:

The dexmedetomidine group exhibited a lower EA incidence, pain, and PONV as compared to the bupivacaine group. No statistically significant differences regarding hemodynamics, OCR, or emergence time were found between both the groups.

Conclusion:

The addition of dexmedetomidine to bupivacaine in sub-Tenon's block can alleviate postoperative EA and nausea and vomiting with better pain management and hemodynamic stability in pediatric strabismus surgery under sevoflurane anesthesia.
Cytokine Expression and Anti-Microbial Effectiveness of Different Calcium Hydroxide Dilutions
Authors: Binanzan Najla , Alsalleeh Fahd
Published: August 2022

Aims:

To determine the cytokine expression by human gingival fibroblasts in response to different calcium hydroxide (Ca(OH)2) dilutions and test the effectiveness of these dilutions in root canal dentin infected with Enterococcus faecalis (E. faecalis).

Methods:

UltraCal XS Ca(OH)2 dilutions were prepared (60, 10, and 1 mg\mL) and co-cultured with gingival fibroblasts for 24 and 48 hours. Untreated cells were used as controls. Expressions of interleukin (IL-1β), tumour necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), and IL-10 were analysed with real-time polymerase chain reaction (PCR). Root canals of extracted human teeth were inoculated with E. faecalis. After 21 days, canals were medicated with Ca(OH)2 dilutions for 7 days. Samples were taken to determine bacterial reduction using quantitative PCR. Analysis of variance, Tukey post-test, and Wilcoxon matched pair test were used for statistics.

Results:

IL-1β and TNF-α expressions of all Ca(OH)2 dilutions were higher at 24 and 48 hours compared to the control. Similarly, all Ca(OH)2 dilutions induced TGF-β expression at 24 hours compared to the control and continued to be higher in 60 mg/mL groups at 48 hours. In contrast, IL-10 was constitutively expressed by untreated cells in the control group and was down-regulated significantly by all Ca(OH)2 dilutions at 24 and 48 hours. All dilutions demonstrated a significant E. faecalis reduction (P < 0.001) with no significant difference between dilution groups (P > 0.05).

Conclusions:

All Ca(OH)2 dilutions had a differential inflammatory effect on fibroblasts and had a down-regulation effect to IL-10. All dilutions tested were effective against E. faecalis, with 60 mg/mL having the highest bacterial reduction.
Comparative Evaluation of Remineralisation Potential of Bioactive Glass, Casein Phosphopeptide-Amorphous Calcium Phosphate and Novel Strontium-Doped Nanohydroxyapatite Paste
Authors: Rajendran Ratheesh , Hussain M Sadique , Sandhya Raghu , Thomas Arun Jacob , Ameena M , Saleem Shinu
Published: August 2022

Background:

Many studies explained the importance of remineralisation of early carious lesions with various remineralising agents. In the present study, we incorporated the remineralising agents in a dentifrice, applied that in artificial enamel caries and evaluated their remineralising potential and compared the efficacy among the three.

Aim:

To evaluate and compare the remineralisation potential of a dentifrice containing bioactive glass, casein phosphopeptide-amorphous calcium phosphate and novel laboratory synthesised strontiumdoped nanohydroxyapatite paste in artificial enamel caries.

Methods and Materials:

120 enamel specimens were divided into 4 groups of 30 specimens each, based on the type of dentifrice applied: GI - conventional toothpaste (control group), GII - calcium sodium phosphosilicate (Novamin), GIII - casein phosphopeptide-amorphous calcium phosphate (GC tooth mousse) and GIV- Novel strontiumdoped nanohydroxyapatite paste (SrnHAp paste). Specimens in all the groups were subjected to demineralisation, and calcium/phosphorous ratio was analysed followed by remineralisation and the mean calcium–phosphorus ratio was assessed using a scanning electron microscope and energy dispersing X-ray analysis.

Statistical Analysis:

Data were analysed using IBM SPSS Statistics for Windows Software, version 22 (IBM Corp., Armonk, NY, USA). Descriptive statistics were used to calculate the mean and standard deviation. Kruskal-Wallis, ANOVA and Mann–Whitney tests were used. The level of significance was set at 5%.

Results and Conclusion:

All except the control group showed a net increase in calcium and phosphorous values after application of the respective remineralising agents in respective groups. Inter-group comparison revealed that Group IV - SrnHAp paste yields higher net calcium and phosphorous values than other groups. Hence, novel SrnHAp can be considered as the material of choice in remineralising early enamel carious lesions.
Volatile Organic Compounds in Human Breath
Authors: Karunagaran Monika , Ramani Pratibha , Gheena S , Abilasha R , Hannah R
Published: August 2022

A comprehensive analysis of volatile organic compounds (VOCs) from the exhaled breath sample is termed as breathomics. Breath samples are a complex mixture composed of a multitude of VOCs and other molecules. The analysis of total VOCs in exhaled breath provides a promising tool for the diagnosis of many diseases because it enables the observation of biochemical processes in the body in a non-invasive way. VOCs are produced in various physiological and pathophysiological conditions thus making it a potential biomarker for several diseases.
Pensar el Bicentenario
Authors: Hoces López Luis R.
Published: August 2022

Reflexionar y abordar el tema de la lucha por la independencia implica en este momento pensar los Bicentenarios. En la II Cumbre de Las Regiones por el Bicentenario en la ciudad de Ayacucho el Historiador Boliviano Guillermo Rodríguez Ostria señaló que no hay un solo camino sino varios, que fueron diversos, distintos y contradictorios. Que no debemos estudiarlos solo con las claves locales sino más bien trabajarlos en una escala supranacional y además localmente.
SACERDOTE GUERRERO DE SIPÁN
Authors: Arroyo Ríos Marcelo
Published: August 2022

Precisamente en el periodo conocido en arqueología como Intermedio-Temprano (100-750 d.C.) se desarrolla una de las culturas que mayor información histórica está proporcionando en el Perú en los últimos 60 años. Esta civilización es llamada MOCHE, por el padre de la arqueología peruana, Julio C. Tello, y tuvo su radio cultural-geográfico en la costa norte del Perú. Su centro político-administrativo estuvo ubicado en los diferentes valles principales como: Moche Chicama, Virú, Lambayeque y Piura.
First De novo whole genome sequencing and assembly of mutant Dendrobium hybrid cultivar ‘Emma White’
Authors: Sherpa Rubina , Devadas Ramgopal , Suprasanna Penna , Bolbhat Sadashiv Narayan , Nikam Tukaram Dayaram
Published: August 2022

The Dendrobium hybrid cultivar ‘Emma White’ is an ornamental, successfully commercialised orchid. We used a gamma ray-induced early flowering mutant and the Illumina HiSeqX10 sequencing platform to generate the first draft de novo whole genome sequence and assembly. The draft sequence was 678,650,699 bp in length, comprising 447,500 contigs with an N50 of 1423 and 33.48% GC content. Comparing 95,529 predicted genes against the Uniprot database revealed 60,741 potential genes governing molecular functions, biological processes and cellular components. We identified 216,232 simple sequence repeats and 138,856 microsatellite markers. Chromosome-level genome assembly of Dendrobium huoshanense was used to RagTag-scaffold available contigs of the mutant, revealing a total length of 687,254,899 bp with an N50 of 2096. The longest final contiguous length was 18,000,059 bp from 30,571 bp. BUSCO genome completeness was 93.6%. This study is valuable for investigating the mechanisms of mutation, and developing Dendrobium hybrid cultivars using mutation breeding.
Extensions of Meir-Keeler Contraction via w-Distances with an Application
Authors:   Faculty of Basic Sciences, University of Bojnord, Iran, BAROOTKOOB SEDIGHEH , KARAPINAR ERDAL , LAKZIAN HOSEIN , CHANDA ANKUSH ,   National Institute of Technology Durgapur, Durgapur, India
Published: August 2022

In this article, we conceive the notion of a generalized (α, ψ, q)-MeirKeeler contractive mapping and then we investigate a fixed point theorem involving such kind of contractions in the setting of a complete metric space via a w-distance. Our obtained result extends and generalizes some of the previously derived fixed point theorems in the literature via w-distances. In addition, to validate the novelty of our findings, we illustrate a couple of constructive numerical examples. Moreover, as an application, we employ the achieved result to earn the existence criteria of the solution of a kind of non-linear Fredholm integral equation.
Estudios multicéntricos y registros, apuestas de la investigación de PANLAR
Authors: Fajardo Estefanía
Published: August 2022

Registros evaluando aspectos de la artritis reumatoide, estudios multicéntricos de espondiloartritis axial, así como caracterización, revisión y análisis de diferentes patologías hacen parte de las investigaciones que se presentan en el Congreso PANLAR 2022.
O impacto da covid-19 em pacientes com doenças autoimunes
Authors: Fajardo Estefanía
Published: August 2022

É mais frequente o covid em pacientes com doenças autoimunes? É mais ou menos grave nesses pacientes? É mais ou menos mortal? Perguntas que buscam uma resposta através destas investigações e análises apresentadas no congresso.
Safe and effective vaccines against covid-19 in rheumatic patients
Authors: Fajardo Estefanía
Published: August 2022

What is the safety and efficacy of vaccines in Latin America and specifically in rheumatic patients in the region? Different research groups set themselves the task of carrying out these different studies and analyzes that allow greater security and support in decision-making
Encouraging the Entrepreneurial Transformation of Honey Beekeepers Through Entrepreneurial Characteristics
Authors:   Department of Management, Universitas Dian Nusantara, Indonesia
Published: August 2022

This study aims to analyze the effect of different predictor variables on the response variable. This study explains the relationship between entrepreneurial characteristics and Innovative Capability on the entrepreneurial performance of honey seekers and sellers who have transformed into honey cultivation entrepreneurs. Based on a comprehensive survey among honey beekeepers by testing a conceptual model to provide evidence on the effects of engagement and entrepreneurial characteristics and Innovative Capability and their influence on the level of Entrepreneurial Performance of honey bee farmers. The population in this study was honey bee farmers. This study uses a quantitative descriptive method. The respondents in this study were beekeepers or managers. It was started by conducting FGD with buyers of honey harvest as collectors, owners of honey bee farms, and farm managers. From these results, conceptual research was developed to enforce the hypothesis. This type of research is quantitative, with a sample of owners or managers of honey bee farms that have experienced harvests. Data collection was carried out utilizing a survey using a questionnaire instrument. The number of respondents is 44, which is a saturated sample. The results of this research are expected to be a contribution from the academic aspect for farmer entrepreneurship actors to increase community productivity in farmer entrepreneurship with honey bee cultivation. Especially for bee seekers who want to transform into entrepreneurs. As for the academic benefits, the results of this study can add to the repertoire of knowledge, especially in the realm of farmer entrepreneurship.
“Eu acho que afetividade estreita os laços”: a construção discursiva do papel do afeto no processo de ensino-aprendizagem
Authors: Abreu Diego Candido , Silva Joice Gomes da
Published: August 2022

O objetivo do presente trabalho é gerar entendimentos sobre a forma que um grupo de professoras entrevistadas constrói discursivamente suas visões sobre o papel da afetividade no processo de ensino e aprendizagem e analisar a forma como as narrativas possibilitam interacionalmente tais construções. Para isso, toma-se como alicerce o arcabouço teórico que parte de uma perspectiva vygotskyana sobre o papel do afeto no processo de ensino-aprendizagem (VYGOTSKY, 1993) em articulação com a reflexão acerca das narrativas (LABOV, 1972), dialogando com a concepção flexibilizadora da análise das narrativas, presente na visão das “pequenas histórias” (BAMBERG; GEORGAKOPOULOU, 2008), e com os preceitos da Linguística Aplicada (MOITA LOPES, 2006). Metodologicamente, estruturou-se o presente trabalho à luz de uma abordagem qualitativa. Foram realizadas entrevistas semiestruturadas com duas professoras de português, estabelecendo, como eixo temático para as conversas, questões relacionadas ao papel dos afetos na vida em sala de aula. Os resultados obtidos apontam a tendência de se tentar sustentar narrativamente as visões teóricas construídas sobre o tema do afeto na sala de aula, ainda que a partir de vivências contraditórias.
Smart Factory e a indústria 4.0: uma revisão sistemática de literatura
Authors: Gori Rodrigo Soares Lelis , Gori Deine Danielle Lelis
Published: August 2022

A mudança de uma fábrica tradicional para uma Smart Factory estimula o efeito profundo e duradouro da manufatura futura em todo o mundo. Como o coração da Indústria 4.0, a Smart Factory integra estruturas físicas com tecnologias dessa indústria, tornando-as mais precisas, com o propósito de melhorar o desempenho, qualidade, controle, gerenciamento e transparência dos processos de manufatura. Nessa perspectiva, o principal objetivo deste estudo é apresentar os desafios para implementação da Smart Factory no contexto da Indústria 4.0. Para o propósito desta pesquisa, foi elaborada uma Revisão Sistemática da Literatura (RSL), metodologia que agrupa trabalhos anteriores sobre um tema especifico, promovendo a identificação, a avaliação e a interpretação de estudos em uma determinada área por meio da análise de conceitos e práticas. Com base nos resultados obtidos, verificou-se que as principais indústrias começaram a jornada para implementar a Smart Factory, no entanto, a maioria ainda carece de compreensão sobre os desafios e recursos para implementá-la. Smart Factory não significa fábrica sem seres humanos, mas sim visa atender as necessidades individuais do mercado, tanto quanto possível, com custos razoáveis. Portanto, este artigo contribui para o corpo de conhecimento atual sobre a Smart Factory, identificando os seus requisitos e os principais desafios, investigando as principais tecnologias da Indústria 4.0 para implementação de uma Smart Factory, bem como também indicam os rumos de possíveis pesquisas futuras.
A produção científica e o trabalho de professores pesquisadores da educação básica federal
Authors: VASQUES DANIEL GIORDANI , Nedel Oliveira Victor Hugo
Published: August 2022

Pensar o trabalho do professor configura-se como importante estratégia de compreensão das atividades docentes e sua produtividade. O objetivo do texto foi analisar a produção científica de pesquisadores docentes de uma escola federal de ensino básico. Realizou-se uma investigação de análise curricular, com a busca pelos coordenadores de pesquisa e da seleção dos dados de produções escritas, eventos científicos e orientações, no período de 2017 a 2020. Dos 37 coordenadores de pesquisa, a maioria é de mulheres (67,5%) e de doutores (73%). A maioria não produziu material escrito (média de 53%) nem orientou estudantes de iniciação científica (62%). Quanto à participação em eventos, 76% dos sujeitos participaram ao menos de um evento. É possível considerar que o aumento de demandas relacionadas ao ensino e à administração toma tempo dos docentes e impacta a dedicação à pesquisa. A indissociabilidade ensino-pesquisa-extensão, uma garantia constitucional, deve ser, portanto, mantida e efetivada.