bluuebunny/crossref_metadata_2025 huggingface dataset:
It’s awe-fully unfamiliar: The effect of familiarity on awe within a virtual reality setting
Authors: Ochadleus Cassidy , Kirby Charissa , Scollon Christie Napa
Published: February 2023

Awe-inducing scenes are purported to involve vastness and a need for accommodation. Familiarity with a stimulus should reduce the need for accommodation, thereby reducing the intensity of awe experienced. The present study tested the effect of familiarity to a natural awe-inducing scene on the experience of awe. Forty undergraduate participants (N = 40) participated in a virtual reality experiment. Using a within-subjects design, participants viewed (in counterbalanced order) an awe-inducing nature scene that was either familiar or unfamiliar. The dependent measure was self-reported awe. Results confirmed that participants experienced diminished awe while viewing a familiar awe-inducing scene compared to viewing an unfamiliar awe-inducing scene.
The causal role of gastroesophageal reflux disease in anxiety disorders and depression: A bidirectional Mendelian randomization study
Authors: Zeng Youjie , Cao Si , Yang Heng
Published: February 2023

Background

Observational studies have shown an association between gastroesophageal reflux disease (GERD) and anxiety disorders/depression. However, these evidences may be influenced by confounding factors. Therefore, our study aimed to determine the causal relationship between GERD and anxiety disorders/depression by conducting a bidirectional Mendelian randomization (MR) study.

Methods

We performed a bidirectional MR analysis using summary statistics from genome-wide association studies (GWAS) in European individuals. The inverse-variance weighted (IVW) method was used as the primary analytical method to assess causality. In addition, five additional MR methods [maximum likelihood, MR-Egger, weighted median, robust adjusted profile score (MR-RAPS), and mode-based estimate (MR-MBE)] were performed to supplement the IVW results. Furthermore, several sensitivity analyses were performed to assess heterogeneity, horizontal pleiotropy, and stability. Finally, a multivariable MR (MVMR) analysis was performed to determine the causal relationship by adjusting for potential confounders.

Results

MR results of the IVW method indicated that GERD significantly increases the risk of anxiety disorders [odds ratio (OR) = 1.35, 95% confidence interval (CI) 1.15–1.59, P = 2.25 × 10–4] and depression (OR = 1.32, 95% CI: 1.15–1.52, P = 1.26 × 10–4). In addition, the MR results of maximum likelihood, MR-Egger, weighted median, MR-RAPS, and MR-MBE remained parallel to the IVW results. Furthermore, sensitivity analysis suggested that the results were robust, with no pleiotropy or heterogeneity detected. Nevertheless, reverse MR analysis showed that anxiety or depression did not increase GERD risk. Finally, MVMR analysis showed that the effect of GERD on increasing the risk of anxiety disorders/depression was independent of confounders.

Conclusion

This MR study supports a causal association between GERD and an increased risk of anxiety disorders and depression. Therefore, complementing symptomatic treatment of GERD with psychological assessment and necessary psychological support therapy may help reduce the risk of future anxiety disorders and depression.
Age at SARS-CoV-2 infection and psychological and physical recovery among Chinese health care workers with severe COVID-19 at 28 months after discharge: A cohort study
Authors: Li Qian , Xiong Lijuan , Cao Xiongjing , Xiong Huangguo , Zhang Yanzhao , Fan Yunzhou , Tang Liang , Jin Yang , Xia Jiahong , Hu Yu
Published: February 2023

Background

No prior study had reported the psychological and physical recovery of patients with COVID-19 2~3 years after discharge from the hospital. Moreover, it is not clear whether there is any difference in the health status of the patients with COVID-19 of different ages after discharge from the hospital.

Methods

Embedding in the “Rehabilitation Care Project for Medical Staff Infected with COVID-19” in China, this study included 271 health care workers (HCWs) with severe COVID-19. Their status of health-related quality of life, persistent symptoms, functional fitness and immune function at 28 months after discharge were followed, and compared according to tertiles of age at SARS-CoV-2 infection (group of younger (≤ 33 years); medium (34-42 years); and older (≥43 years)). Multivariate linear regression and multivariable adjusted logistic regression models were applied in investigating the associations of age at SARS-CoV-2 infection and outcomes.

Results

At 28 months after discharge, 76% of the HCWs with severe COVID-19 had symptom of fatigue/weakness; 18.7% of the HCWs with severe COVID-19 did not fully recover their functional fitness; the decrease of CD3+ T cells, CD8+ T cells and the increase of natural killer cells accounted for 6.6, 6.6, and 5.5%, respectively. Compared with the HCWs with severe COVID-19 in younger group, HCWs with severe COVID-19 in older group had lower scores regarding physical functioning, role physical, bodily pain and role emotional; HCWs with severe COVID-19 in older group had higher risk of cough, joint pain, hearing loss and sleep disorder; HCWs with severe COVID-19 in older group scored lower on flexibility test. The variance of relative numbers of CD3+ T cells, CD8+ T cells and natural killer cells among HCWs with severe COVID-19 of different age groups were significant.

Conclusions

This study demonstrated that older HCWs with severe COVID-19 recovered slower than those with younger age regarding health-related quality of life, persistent symptoms, functional fitness and immune function at 28 months after discharge. Effective exercise interventions regarding flexibility should be performed timely to speed their rehabilitation, especially among those with older age.
Patient satisfaction impact indicators from a psychosocial perspective
Authors: Wang Yao , Liu Chenchen , Wang Pei
Published: February 2023

Background

Patient satisfaction plays an important role in improving patient behavior from care, reducing healthcare costs, and improving outcomes. However, since patient satisfaction is a multidimensional concept, it remains unclear which factors are the key indicators of patient satisfaction. The purpose of this study was to verify whether and how patients' psychosocial perceptions of physicians influenced patient satisfaction.

Method

In China, 2,256 patients were surveyed on stereotypes of physicians, institutional trust, humanized perception, and communication skills, as well as patient expectations and patient satisfaction. The data were analyzed using structural equation modeling.

Results

Stereotypes, institutional trust, and humanized perception have an indirect effect on patient satisfaction through communication, and patient expectations have a direct effect on patient satisfaction.

Conclusions

“Patient-centered” communication is the key to improving patient satisfaction, while positive stereotypes at the societal level, standardization of organizational institutions, expression of the doctor's view of humanity in the doctor-patient interaction, and reasonable guidance of patient expectations are important for improving patient satisfaction.
Early career scientists converse on the future of soft robotics
Authors: Tauber Falk J. , Slesarenko Viacheslav
Published: February 2023

During the recent decade, we have witnessed an extraordinary flourishing of soft robotics. Rekindled interest in soft robots is partially associated with the advances in manufacturing techniques that enable the fabrication of sophisticated multi-material robotic bodies with dimensions ranging across multiple length scales. In recent manuscripts, a reader might find peculiar-looking soft robots capable of grasping, walking, or swimming. However, the growth in publication numbers does not always reflect the real progress in the field since many manuscripts employ very similar ideas and just tweak soft body geometries. Therefore, we unreservedly agree with the sentiment that future research must move beyond “soft for soft’s sake.” Soft robotics is an undoubtedly fascinating field, but it requires a critical assessment of the limitations and challenges, enabling us to spotlight the areas and directions where soft robots will have the best leverage over their traditional counterparts. In this perspective paper, we discuss the current state of robotic research related to such important aspects as energy autonomy, electronic-free logic, and sustainability. The goal is to critically look at perspectives of soft robotics from two opposite points of view provided by early career researchers and highlight the most promising future direction, that is, in our opinion, the employment of soft robotic technologies for soft bio-inspired artificial organs.
Quantifying the global solar wind-magnetosphere interaction with the Solar-Terrestrial Observer for the Response of the Magnetosphere (STORM) mission concept
Authors: Sibeck David G. , Murphy Kyle R. , Porter F. Scott , Connor Hyunju K. , Walsh Brian M. , Kuntz Kip D. , Zesta Eftyhia , Valek Phil , Baker Charles L. , Goldstein Jerry , Frey Harald , Hsieh Syau-Yun , Brandt Pontus C. , Gomez Roman , DiBraccio Gina A. , Kameda Shingo , Dwivedi Vivek , Purucker Michael E. , Shoemaker Michael , Petrinec Steven M. , Aryan Homayon , Desai Ravindra T. , Henderson Michael G. , Cucho-Padin Gonzalo , Cramer W. Douglas
Published: February 2023

Much of what we know about the solar wind’s interaction with the Earth’s magnetosphere has been gained from isolated in-situ measurements by single or multiple spacecraft. Based on their observations, we know that reconnection, whether on the dayside magnetopause or deep within the Earth’s magnetotail, controls the bulk flow of solar wind energy into and through the global system and that nightside activity provides the energized particles that power geomagnetic storms. But by their very nature these isolated in-situ measurements cannot provide an instantaneous global view of the entire system or its cross-scale dynamics. To fully quantify the dynamics of the coupled solar wind-magnetosphere requires comprehensive end-to-end global imaging of the key plasma structures that comprise the magnetosphere which have spatial resolutions that exceeds anything possible with multi-point or constellation situ measurements. Global, end-to-end, imaging provides the pathway to understanding the system as a whole, its constituent parts, and its cross-scale processes on a continuous basis, as needed to quantify the flow of solar wind energy through the global magnetospheric system. This paper describes how a comprehensively-instrumented single spacecraft in a high-altitude, high-inclination orbit coupled with ground-based instruments provides the essential observations needed to track and quantify the flow of solar wind energy through the magnetosphere. This includes observations of the solar wind plasma and magnetic field input, the magnetopause location in soft X-rays, the auroral oval in far ultraviolet, the ring current in energetic neutrals, the plasmasphere in extreme ultraviolet, the exosphere in Lyman-α, and the microstructure of the nightside auroral oval from ground-based all sky cameras.
Global trends in research of high-throughput sequencing technology associated with chronic wounds from 2002 to 2022: A bibliometric and visualized study
Authors: Meng Hao , Peng Yu , Li Pinxue , Su Jianlong , Jiang Yufeng , Fu Xiaobing
Published: February 2023

Background

Chronic wounds are a complex medical problem. With the difficulty of skin healing, the microbial ecology of chronic wounds is an essential factor affecting wound healing. High-throughput sequencing (HTS) technology is a vital method to reveal the microbiome diversity and population structure of chronic wounds.

Objective

The aim of this paper was to delineate the scientific output characteristics, research trends, hotspots and frontiers of HTS technologies related to chronic wounds globally over the past 20 years.

Methods

We searched the Web of Science Core Collection (WoSCC) database for articles published between 2002 and 2022 and their full record information. The Bibliometrix software package was used to analyze bibliometric indicators and VOSviewer visualization analysis results.

Results

Ultimately, a total of 449 original articles were reviewed, and the results showed that the number of annual publications (Nps) about HTS associated with chronic wounds has steadily increased over the last 20 years. The United States and China produce the most articles and have the highest H-index, while the United States and England have the largest number of citations (Nc) in this field. The University of California, Wound Repair and Regeneration and National Institutes of Health Nih United States were the most published institutions, journals and fund resources, respectively. The global research could be divided into 3 clusters as follows: microbial infection of chronic wounds, the healing process of wounds and microscopic processes, skin repair mechanism stimulated by antimicrobial peptides and oxidative stress. In recent years, “wound healing”, “infections”, “expression”, “inflammation”, “chronic wounds”, “identification” and “bacteria” “angiogenesis”, “biofilms” and “diabetes” were the most frequently used keywords. In addition, research on “prevalence”, “gene expression”, “inflammation” and “infection” has recently become a hotspot.

Conclusions

This paper compares the research hotspots and directions in this field globally from the perspectives of countries, institutions and authors, analyzes the trend of international cooperation, and reveals the future development direction of the field and research hotspots of great scientific research value. Through this paper, we can further explore the value of HTS technology in chronic wounds to better solve the problem of chronic wounds.
Comparison of single- and double-spaced feeders with regard to damaging behavior in pigs
Authors: D'Alessio Roberta Maria , Hanlon Alison , O'Driscoll Keelin
Published: February 2023

This work compared the behavior and performance of 24 groups of 12 pigs kept in pens with either a DOUBLE [one feed space aligned with the front wall of the pen (WALL), and one immediately adjacent (IN)] or SINGLE (WALL only) spaced feeder, from weaning until slaughter. Pens were equipped with a rack of fresh grass and a rubber toy (weaning phase) or a wooden board (finishing phase). Every 2 weeks, interaction with the enrichment, aggressive, harmful, and play behaviors were recorded for 5 min, four times a day. In addition, the pigs were individually assessed every 2 weeks for ear, tail, and flank injuries using a 4-point scale. The duration of feeder occupancy, feed space occupancy, number of and duration of feeding bouts, and aggressive behavior at the feeder were recorded continuously from video recordings (two times while in the weaner stage and two times while in the finisher stage, one camera/pen; 1 h per occasion). Individual body weight was recorded at weaning, transfer, and slaughter, and feed delivery was recorded daily at the pen level; from these measurements, average daily gain, feed intake, and feed conversion ratio were calculated. Data were analyzed using SAS v9.4. There was no effect of treatment on damaging behaviors. Pigs in DOUBLE had worse tail lesion scores on 6 of the 9 recording days (P < 0.001), but values rarely exceeded 1. Total feeder occupancy tended to be longer in DOUBLE than in SINGLE (P = 0.06). DOUBLE selected the IN feed space more often than WALL regarding the number of feeding bouts (P < 0.001). During feeding, pigs in DOUBLE received fewer aggressive behaviors than SINGLE (P < 0.001) and experienced fewer displacements than SINGLE (P < 0.001). Although both experimental groups had a similar weight at slaughter (P > 0.05), the FCR was lower in DOUBLE than in SINGLE (P < 0.05). These data suggest that doubling space at the feeder to two spaces/12 pigs reduced aggression and displacement behaviors at the feeder, indicating less competition for food. However, increasing feeder space was not a management strategy that could ensure reduced tail biting on commercial pig farms.
Effects of Lactobacillus plantarum fermented Shenling Baizhu San on gut microbiota, antioxidant capacity, and intestinal barrier function of yellow-plumed broilers
Authors: Lv Weijie , Ma Yimu , Zhang Yingwen , Wang Tianze , Huang Jieyi , He Shiqi , Du Hongliang , Guo Shining
Published: February 2023

The current study focused on the effects of Shenling Baizhu San (SLBZS) fermented by Lactobacillus plantarum (L. plantarum) on gut microbiota, antioxidant capacity, and intestinal barrier function of yellow-plumed broilers. Our results showed that the content of ginsenoside Rb1 was the highest when SLBZS were inoculated with 3% L. plantarum and fermented at 28°C for 24 h. One-day-old male broilers were divided into five treatment groups. Treatment consisted of a basal diet as a control (Con), 0.1% unfermented SLBZS (U-SLBZS), 0.05% fermented SLBZS (F-SLBZS-L), 0.1% fermented SLBZS (F-SLBZS-M), and 0.2% fermented SLBZS (F-SLBZS-H). On days 14, 28, and 42, six chickens from each group were randomly selected for blood collection and tissue sampling. The results showed that the addition of 0.1% fermented SLBZS could significantly increase average daily feed intake (ADFI) and average daily gain (ADG), and decrease feed conversion ratio (FCR) of broilers. The addition of 0.1 and 0.2% fermented SLBZS significantly increased the lymphoid organ index of broilers on day 28 and 42. The addition of 0.1 and 0.2% fermented SLBZS could improve the antioxidant capacity of broilers. Moreover, the addition of 0.1 and 0.2% fermented SLBZS could significantly increase the villus height/crypt depth of the ileum, and significantly increase the expression of tight junction. In addition, fermentation of SLBZS increase the abundance of Coprococcus, Bifidobacterium and Bilophila in the gut of broilers. These results indicate that the supplementation of fermented SLBZS in the diet could improve the growth performance, lymphoid organ index, antioxidant capacity, and positively affect the intestinal health of broilers.
Transcriptional Plasticity and Cell Wall Characterization in High-Methanol-Producing Transgenic Tobacco Plants
Authors: Dixit Sameer , Chandrashekar Krishnappa , Upadhyay Santosh Kumar , Verma Praveen Chandra
Published: February 2023

Volatile organic compounds emanating from plant surfaces serve as a sustainable natural solution to combat biotic stresses in plants. Leaf methanol is the simplest and second major volatile organic compound after isoprene emitted through the leaf surface. Methanol has been neglected as a by-product of other secondary metabolites for a long time, but recent studies have suggested its importance in development and stress responses. In our previous findings, we had revealed that transgenic plants over-expressing PME, enhanced methanol production providing resistance against a broad spectrum of insects. In the current study, we extended our previous work to provide new insights by performing differential transcriptomics of high-methanol-producing insect-resistant transgenic lines. We found that 2262 genes were differentially expressed in the transgenics plants, including transcription factors, cell wall modulating, phytohormones signaling and development-related genes. Our results demonstrated that the expression levels of transcription factors associated with development and biotic stress were altered in the transgenic lines. In addition, phytohormones ABA and gibberellin signalling genes were upregulated, whereas ethylene and auxin signalling genes were downregulated. Moreover, biochemical characteristics of cell walls in both transgenic tobacco plants were comparable to the control plants.
Influence of Moisture Content and Composition of Agricultural Waste with Hard Coal Mixtures on Mechanical and Rheological Properties
Authors: Przywara Mateusz , Przywara Regina , Chutkowski Marcin , Zapała Wojciech , Opaliński Ireneusz
Published: February 2023

Utilization of agricultural waste can be done by converting it with conventional fuels to energy. For this purpose, it is necessary to understand the properties of waste and its mixture with the fossil fuels important for its storage and conversion. The objective of the work was to examine the influence of moisture content and the composition of agricultural waste with hard coal mixtures on the mechanical and rheological properties of the waste. The materials tested were powdered biomass: dried distillers grains with solubles (DDGS), meat and bone meal (MBM), and hard coal (HC). Mechanical properties were measured to investigate flowability with the Jenike shear tester. A technique with an annular powder rheometer was applied for rheological measurements. It was shown that an increased moisture content worsened the flowability of the mixtures, while an increased biomass content reduced the influence of moisture and stabilized the mechanical properties of the mixtures in quasi-static conditions. In dynamic conditions, moisture decreased the mechanical strength of the mixtures and increased their flowability.
Transcriptome and Proteome Analysis Identifies Salt Stress Response Genes in Bottle Gourd Rootstock-Grafted Watermelon Seedlings
Authors: Wang Yu , Zhou Junqian , Wen Wenxu , Sun Jin , Shu Sheng , Guo Shirong
Published: February 2023

Soil salinization poses a huge challenge to the development of agriculture and seriously decreases crop yield and quality. In recent years, grafting has become one of the key agronomic techniques used to enhance plant abiotic stress tolerance. In this study, we found that watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai] grafted onto bottle gourd (Lagenaria siceraria Standl.) significantly enhanced salt tolerance. Transcriptome analysis revealed that a total of 8462 differentially expressed genes (DEGs) were identified, and the number of up- and down-regulated genes were 3207 and 5255, respectively. The DEGs in the bottle gourd rootstock-grafted plants were mainly involved in carbon metabolism, photosynthesis, and plant hormone signal transduction. Furthermore, proteome analysis identified 28 differently expressed proteins (DEPs) in bottle gourd rootstock-grafted plants under salt stress. These DEPs were closely associated with amino acid and protein synthesis, photosynthesis, mitochondrial metabolism and carbon metabolism, and stress defense. Combined transcriptome and proteome analyses showed that salt stress-responded genes in bottle gourd rootstock-grafted watermelon seedlings were mainly involved in plant hormone signal transduction, photosynthesis, and amino acid synthesis pathways.
Nutrient Content of Vineyard Leaves after Prolonged Treated Wastewater Irrigation
Authors: Ramírez Pilar Mañas , Ibáñez Jorge De las Heras
Published: February 2023

Water is essential for agricultural productivity and is a vital component of food security. In areas with limited water supplies, new water resources must be identified. Given these challenges, we attempted to determine whether the use of treated wastewater for vineyard irrigation is compatible with sensible agricultural methods within the context of a circular economy, where resource sustainability is a key tenet of foodtech. The main purpose of this study was to determine whether using treated wastewater for vineyard irrigation influences foliar nutrient content identifying differences according to irrigation water. A field experiment was designed to compare vineyards that had been irrigated with treated wastewater for years to those that had been irrigated with conventional well water. For characterization, water and soil were analyzed. Furthermore, the macro and micronutrient contents of vine leaves, as well as chlorophyll (SPAD units) measured directly in the field, were tracked over several seasons to determine the relationship between them. We found no nutritional imbalances in the crop at the end of the study, although there were improvements in the concentrations of some nutrients (Mg, Mn and Zn). It was also noticed that plots irrigated with treated wastewater run the risk of increasing soil saline concentrations.
BMAE-Net: A Data-Driven Weather Prediction Network for Smart Agriculture
Authors: Kong Jian-Lei , Fan Xiao-Meng , Jin Xue-Bo , Su Ting-Li , Bai Yu-Ting , Ma Hui-Jun , Zuo Min
Published: February 2023

Weather is an essential component of natural resources that affects agricultural production and plays a decisive role in deciding the type of agricultural production, planting structure, crop quality, etc. In field agriculture, medium- and long-term predictions of temperature and humidity are vital for guiding agricultural activities and improving crop yield and quality. However, existing intelligent models still have difficulties dealing with big weather data in predicting applications, such as striking a balance between prediction accuracy and learning efficiency. Therefore, a multi-head attention encoder-decoder neural network optimized via Bayesian inference strategy (BMAE-Net) is proposed herein to predict weather time series changes accurately. Firstly, we incorporate Bayesian inference into the gated recurrent unit to construct a Bayesian-gated recurrent units (Bayesian-GRU) module. Then, a multi-head attention mechanism is introduced to design the network structure of each Bayesian layer, improving the prediction applicability to time-length changes. Subsequently, an encoder-decoder framework with Bayesian hyperparameter optimization is designed to infer intrinsic relationships among big time-series data for high prediction accuracy. For example, the R-evaluation metrics for temperature prediction in the three locations are 0.9, 0.804, and 0.892, respectively, while the RMSE is reduced to 2.899, 3.011, and 1.476, as seen in Case 1 of the temperature data. Extensive experiments subsequently demonstrated that the proposed BMAE-Net has overperformed on three location weather datasets, which provides an effective solution for prediction applications in the smart agriculture system.
Sequence Order in the Range 1 to 19 by Chimpanzees on a Touchscreen Task: Processing Two-Digit Arabic Numerals
Authors: Muramatsu Akiho , Matsuzawa Tetsuro
Published: February 2023

The sequence of Arabic numerals from 1 to 19 was taught to six chimpanzees, three pairs of mother and child. Each chimpanzee participant sat facing a touchscreen on which the numerals appeared in random positions within an imaginary 5-by-8 matrix. They had to touch the numerals in ascending order. Baseline training involved touching the adjacent numerals from 1 to X or from the numeral X to 19. Systematic tests revealed the following results: (1) The range 1 to 9 was easier than 1 to 19. (2) Adjacent numerals were easier than nonadjacent ones. (3) The “masking” (memory task) caused deterioration of performance. All these factors depended on the number of numerals simultaneously presented on the screen. A chimpanzee named Pal mastered the skill of ordering two-digit numerals with 100% accuracy. Human participants were tested in the same experiment with the same procedure. Both species showed relative difficulty in handling two-digit numerals. Global–local information processing is known to be different between humans and other primates. The assessment of chimpanzee performance and comparison with humans were discussed in terms of the possible difference in the global–local dual information processing of two-digit numerals.
Factors Influencing Disease Prevention and Control Behaviours of Hog Farmers
Authors: Wang Jiamei , Hu Xiangdong
Published: February 2023

Animal diseases are a serious threat to animal husbandry production and diet health, and effective prevention and control measures need to be explored. This study investigates the factors influencing the adoption of biosecurity prevention and the control behaviours of hog farmers towards African swine fever and provides appropriate recommendations. Using research data from Sichuan, Hubei, Jiangsu, Tianjin, Liaoning, Jilin, and Hebei, we employed a binary logistic model to empirically analyse these factors. Regarding individual farmer characteristics, male farmers emphasised biosecurity prevention and control in farms, with higher education actively influencing the adoption of prevention and control measures. Farmers who received technical training were actively inclined to adopt such behaviours. Furthermore, the longer the duration of farming, the more probable the farmers were to neglect biosecurity prevention and control. However, the bigger and more specialised the farm, the more inclined they were to adopt prevention and control behaviours. With respect to disease prevention and control awareness, the more risk-averse the farmers were, the more they actively adopted epidemic prevention behaviours. As the awareness of epidemic risk increased, the farmers tended to adopt active epidemic prevention behaviours by reporting suspected outbreaks. The following policy recommendations were made: learning about epidemic prevention and improving professional skills; large-scale farming, specialised farming; and timely dissemination of information to raise risk awareness.
Impact of Nucleic Acid Amplification Test on Clinical Outcomes in Patients with Clostridioides difficile Infection
Authors: Yamada Yota , Miyazaki Motoyasu , Kushima Hisako , Komiya Yukie , Nakashima Akio , Ishii Hiroshi , Imakyure Osamu
Published: February 2023

A nucleic acid amplification test (NAAT) is recommended to determine whether or not patients have a Clostridioides difficile infection (CDI) when the glutamate dehydrogenase activity assay is positive and the rapid membrane enzyme immunoassays for toxins is negative. In our hospital, a NAAT was introduced to diagnose CDI precisely in April 2020. This study aimed to investigate the impact of a NAAT on the clinical outcomes in patients with CDI at our hospital. Seventy-one patients diagnosed with CDI between April 2017 and March 2022 were included in our study. Patients with CDI were divided into two groups: before (pre-NAAT) and after (post-NAAT) the introduction of NAAT. The clinical outcome was compared between the two groups. Of the 71 patients with CDI, 41 were sorted into the pre-NAAT group and 30 into the post-NAAT group. The clinical cure rate was significantly higher in the post-NAAT group compared to the pre-NAAT group (76.7% vs. 48.8%, p = 0.018). In the multivariable analysis, the clinical cure was significantly associated with the introduction of NAAT (p = 0.022). Our findings suggest that the introduction of NAAT can improve the clinical outcomes in CDI patients.
Dietary Strategies for Relieving Stress in Pet Dogs and Cats
Authors: Fan Zhicong , Bian Zhaowei , Huang Hongcan , Liu Tingting , Ren Ruiti , Chen Xiaomin , Zhang Xiaohe , Wang Yingjia , Deng Baichuan , Zhang Lingna
Published: February 2023

A variety of physical, emotional, and mental factors can induce a stress response in pet dogs and cats. During this process, hypothalamus–pituitary–adrenal (HPA) and sympathetic–adrenal medulla (SAM) axes are activated to produce a series of adaptive short-term reactions to the aversive situations. Meanwhile, oxidative stress is induced where there is an imbalance between the production and scavenging of reactive oxygen species (ROS). Oxidative damage is also incorporated in sustained stress response causing a series of chronic problems, such as cardiovascular and gastrointestinal diseases, immune dysfunction, and development of abnormal behaviors. In this review, the effects and mechanisms of dietary regulation strategies (e.g., antioxidants, anxiolytic agents, and probiotics) on relieving stress in pet dogs and cats are summarized and discussed. We aim to shed light on future studies in the field of pet food and nutrition.
Research on Crack Width Measurement Based on Binocular Vision and Improved DeeplabV3+
Authors: Chen Chaoxin , Shen Peng
Published: February 2023

Crack width is the main manifestation of concrete material deterioration. To measure the crack information quickly and conveniently, a non-contact measurement method of concrete planar structure crack based on binocular vision is proposed. Firstly, an improved DeeplabV3+ semantic segmentation model is proposed, which uses L-MobileNetV2 as the backbone feature extraction network, adopts IDAM structure to extract high-level semantic information, introduces ECA attention mechanism, and optimizes the loss function of the model to achieve high-precision segmentation of crack areas. Secondly, the plane space coordinate equation of the concrete structure was constructed based on the principle of binocular vision and SIFT feature point matching, and the crack width was calculated by combining the segmented image. Finally, to verify the performance of the above method, a measurement test platform was built. The experimental results show that the RMSE of the crack measurement by using the algorithm is less than 0.2 mm, and the error rate is less than 4%, which has stable accuracy in different measurement angles. It solves the problem of fast and convenient measurement of the crack width of concrete planar structures in an outdoor environment.
Consequences of Glucose Enriched Diet on Oncologic Patients
Authors: Gonzalez-Flores David , Gripo Ana-Alejandra , Rodríguez Ana-Beatriz , Franco Lourdes
Published: February 2023

Malignant tumors demonstrate increased rates of glucose utilization and uptake. Therefore, clinical trials are being used to evaluate a variety of inhibitors of glycolytic metabolism. Antiglycolytic drugs have been proven to promote chemotherapy and radio-induced cell death. Glucose influences the levels and activation of pro-apoptotic BH3-only proteins, such as Puma, Bad, Noxa, and Bim, and the family of anti-apoptotic proteins Bcl-2; synergistic effects are probably the result of the regulation of the apoptotic machinery. Antiglycolytic medicines and glucose deprivation induce tumor cell death by caspase-8-mediated or mitochondrial apoptosis or even necrosis. The last is known to activate the effector caspases, principally through the cleavage of the Bcl-2 family member Bid and the consequent activation of the mitochondrial pathway. Modifications to the host’s diet can modify the availability of nutrients in the tumor microenvironment, which could offer a feasible technique to restrict growth. Dietary alterations can reduce particular nutritional requirements of the tumor that target the metabolic vulnerabilities or boost the cytotoxicity of anticancer medications. According to recent studies, increasing the amount of key minerals in the diet can affect how well cancer therapies can function. The research reveals that the eating habits and nutritional state of a patient should be regarded during cancer research and therapy.
Effects of Warming and Drought Stress on the Coupling of Photosynthesis and Transpiration in Winter Wheat (Triticum aestivum L.)
Authors: Li Qian , Gao Yang , Hamani Abdoul Kader Mounkaila , Fu Yuanyuan , Liu Junming , Wang Hongbo , Wang Xingpeng
Published: February 2023

The coupling of photosynthesis and transpiration in plant leaves forms the basis of carbon–water coupling in terrestrial ecosystems. Previous studies have attributed the coupling of leaf photosynthesis and transpiration to joint stomata control, but they lack analyses of the coupling mechanism. In this study, winter wheat (Triticum aestivum L.) was selected as a plant material on the North China Plain. Under the conditions of warming and drought stress, the photosynthetic rate (An), transpiration rate (Tr), water pressure saturation (VPD), and leaf temperature (T1) of wheat were recorded on clear days at the jointing, flowering, and grain-filling stages from 9:00 to 12:00 a.m. Then, the measured values were fitted to the simulated values obtained using the Ball–Berry and Penman–Monteith models. The results showed that the stomatal size, stomatal conductance, An, and Tr of winter wheat leaves were decreased by warming, drought stress, and their synergistic effects. Based on the Ball–Berry model, different fitting effects were observed in the treatments of adequate water supply with warming (R-g), water deficit with warming (R-d), adequate water supply without warming (N-g), and water deficit without warming (N-d). The R2 values of the R-g, R-d, N-g, and N-d treatments were 0.962, 0.958, 0.964, and 0.943, respectively. The Tr values were fitted based on the Penman–Monteith model. In the R-g, R-d, N-g, and N-d treatments, the R2 values of the R-g, R-d, N-g, and N-d treatments were 0.923, 0.849, 0.934, and 0.919, respectively. In conclusion, both warming and water deficit reduce stomatal conductance, An, Tr, and the coupling effect of photosynthesis and transpiration.
Laboratorial Simulation for Assessing the Performance of Slates as Construction Materials in Cold Climates
Authors: Sitzia Fabio , Lisci Carla , Pires Vera , Alves Tiago , Mirão José
Published: February 2023

This paper presents the results of a laboratory simulation of a subarctic climate carried out in climatic chamber. Realistic daily and seasonal cycles of temperature of a regular subarctic continental climate without dry seasons (Dfc) were simulated and the physical/mechanical properties and performance of the slates were assessed. The slate was selected because of its use as cladding and roofing material in cold regions. Mechanical performances before and after Dfc climate simulation were evaluated through point load index, uniaxial compression, flexural strength and anchor rupture load. A decrease in these mechanical features between 9 and 50% with respect to the initial strengths has been registered. Other physical parameters such as apparent density, open porosity and water absorption were evaluated. The tests showed an increase in open porosity (+72%) and a decrease in bulk density (−0.7%). The results highlighted a predominantly physical decay and mechanical performance decreasing with a relevant lowering in strength without the detection of chemical–mineralogical alterations. Moreover, artificial sun exposure reproduced the weak solar radiation that characterizes the Dfc climate. This was carried out to assess the aesthetic characteristics of the slate, since discoloration under sun exposure was supposed to occur but the slates did not exhibit substantial color changes.
Evaluation of Inert Dusts on Surface Applications and Factors That Maximize Their Insecticidal Efficacy
Authors: Baliota Georgia V. , Athanassiou Christos G.
Published: February 2023

We evaluated formulations of diatomaceous earth and zeolite originated from natural deposits from Greece as insecticides in concrete and steel surfaces for the control of three major beetle species of stored products: Sitophilus oryzae (L.) (Coleoptera: Curculionidae), Rhyzopertha dominica (F.) (Coleoptera: Bostrychidae) and Tribolium confusum Jacquelin du Val (Coleoptera: Tenebrionidae). The formulations were tested as dusts at 0.5 or 1 g/m2. Our results indicated that, in most of the cases tested, the inert materials caused 100% adult mortality for all three species, even at the lowest dose, after 7 days of exposure. At the same time, there were no considerable differences in the insecticidal effect of the formulations between concrete and steel surfaces. Among the species tested, R. dominica was the most susceptible, followed by S. oryzae and T. confusum. Our results indicate that natural resource-based inert silicaceous deposits could be used with success in stored product protection against insects at dose rates that are comparable with other commercially available inert material-based formulations.
Manual but Not Instrument-Assisted Cervical Manipulation Reduces Pain and Disability in Subjects with Nonspecific Neck Pain: Double-Blinded, Randomized Clinical Trial
Authors: Nogueira Nuno , Oliveira-Campelo Natália , Torres Rui , Sousa Andreia , Ribeiro Fernando
Published: February 2023

There is limited evidence comparing the effects of manual and instrumented-assisted manipulations among adults with neck pain. Our purpose was to determine the effects of a multisession regime of manual and instrument-assisted cervical manipulation on pain, disability, perception of change, and muscle properties in subjects with nonspecific neck pain. We conducted a double-blind, randomized, placebo-controlled study in 32 subjects with nonspecific neck pain. Two groups received three sessions of cervical (C3/C4) manipulation, one group manual and the other instrument-assisted, a third group received three sessions of sham manipulation, and a fourth group served as a control. Self-reported pain, pressure pain thresholds, neck disability, patient perception of change, and properties (tonus, stiffness, and elasticity) of the upper trapezius and biceps brachii were assessed at baseline, immediately after the first session and 15 days after the end of the intervention. After the end of the intervention, the percentage of changes in the visual analogue scale score, Neck Disability Index, and Patient Global Perception of Change score were significantly higher in the manual group in comparison with the other groups (p < 0.05). No between-group differences were observed in the percentage of changes in tonus, stiffness, and elasticity of the four muscles at the end of the intervention. We concluded that three sessions of C3/C4 manual manipulation improved pain and disability in subjects with nonspecific neck pain.
Comparative Assessment of Variable Loads and Seismic Actions on Bridges: A Case Study in Italy Using a Multimodal Approach
Authors: Collura Daniele , Nascimbene Roberto
Published: February 2023

The structural safety of the infrastructure stock is an important issue in modern seismic performance assessments. Following recent seismic events, reports have highlighted the increased vulnerability of physical infrastructural assets, particularly for many bridges across the Italian road and motorway network. Italy possesses one of the most complex and intricate road systems in Europe which was constructed across irregular territories in terms of plan and elevation and of varying dimensions. As such, a comparative case study is presented herein. This case study aims to characterise the seismic vulnerability of the Vizzana-Zampogna viaduct which is part of the A15 Parma-La Spezia motorway, near the locality of Selva Bocchetto. The viaduct is considered representative of the 1970s construction period. It is approximately 342 m in length and is characterized by a flat curvilinear prestressed concrete deck consisting of 15 spans simply supported on reinforced concrete piers. To better understand the seismic structural response of the individual piers of the viaduct, a “multi-modal” nonlinear static analysis was developed, which allows the effects of sectional stresses relative to the variable load profiles of the single modes to be combined through the quadratic modal combination, and to be compared with the relevant limit state. The research aims to qualitatively identify the piers most vulnerable to seismic action and to study the effects that are induced by introducing variable loads and intensity scenarios of different earthquakes.
Honesty-Based Social Technique to Enhance Cooperation in Social Internet of Things
Authors: Muhammad Shad , Umar Muhammad , Khan Shafiullah , Alrajeh Nabil , Mohammed Emad
Published: February 2023

The Social Internet of Things (SIoT) can be seen as integrating the social networking concept into the Internet of Things (IoT). Such networks enable different devices to form social relationships among themselves depending on pre-programmed rules and the preferences of their owners. When SIoT devices encounter one another on the spur of the moment, they seek out each other’s assistance. The connectivity of such smart objects reveals new horizons for innovative applications empowering objects with cognizance. This enables smart objects to socialize with each other based on mutual interests and social aspects. Trust building in social networks has provided a new perspective for providing services to providers based on relationships like human ones. However, the connected IoT nodes in the community may show a lack of interest in forwarding packets in the network communication to save their resources, such as battery, energy, bandwidth, and memory. This act of selfishness can highly degrade the performance of the network. To enhance the cooperation among nodes in the network a novel technique is needed to improve the performance of the network. In this article, we address the issue of the selfishness of the nodes through the formation of a credible community based on honesty. A social process is used to form communities and select heads in these communities. The selected community heads having social attributes prove effective in determining the social behavior of the nodes as honest or selfish. Unlike other schemes, the dishonest nodes are isolated in a separate domain, and they are given several chances to rejoin the community after increasing their honesty levels. The proposed social technique was simulated using MATLAB and compared with existing schemes to show its effectiveness. Our proposed technique outperforms the existing techniques in terms of throughput, overhead, packet delivery ratio (PDR), and packet-delivery latency.
DAG Hierarchical Schedulability Analysis for Avionics Hypervisor in Multicore Processors
Authors: Yang Huan , Zhao Shuai , Shi Xiangnan , Zhang Shuang , Guo Yangming
Published: February 2023

Parallel hierarchical scheduling of multicore processors in avionics hypervisor is being studied. Parallel hierarchical scheduling utilizes modular reasoning about the temporal behavior of the upper Virtual Machine (VM) by partitioning CPU time. Directed Acyclic Graphs (DAGs) are used for modeling functional dependencies. However, the existing DAG scheduling algorithm wastes resources and is inaccurate. Decreasing the completion time (CT) of DAG and offering a tight and secure boundary makes use of joint-level parallelism and inter-joint dependency, which are two key factors of DAG topology. Firstly, Concurrent Parent and Child Model (CPCM) is researched, which accurately captures the above two factors and can be applied recursively when parsing DAG. Based on CPCM, the paper puts forward a hierarchical scheduling algorithm, which focuses on decreasing the maximum CT of joints. Secondly, the new Response Time Analysis (RTA) algorithm is proposed, which offers a general limit for other execution sequences of Noncritical joints (NC-joints) and a specific limit for a fixed execution sequence. Finally, research results show that the parallel hierarchical scheduling algorithm has higher performance than other algorithms.