bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Promosi untuk Menarik Minat Nasabah di BMT UGT Sidogiri Cabang Pembantu Mumbulsari Kabupaten Jember
Authors: Hasanah Kharina Malihatul
Published: November 2023

The fourth component of the marketing mix is promotion strategy, which is a sort of communication used to educate and persuade potential customers about products and services. Promotion may be beneficial for both consumers and producers. The purpose of this study is to determine how well promotional strategies to pique customer interest are being used at BMT UGT Sidogiri, Mumbulsari Sub-Branch, Jember Regency. This study employs qualitative research, collecting data through observation, interviews, and recording, and then analyzing it according to Miles and Huberman's theoretical framework. According to the study's findings, the BMT UGT Sidogiri Mumbulsari sub-branch employs both advertising promotions and face-to-face sales promotions as part of its promotional efforts to pique customers' interest.
Central Catheter-Induced Cardiac Tamponade in Neonates: Two Case Reports
Authors: Kim Hyungtae , Choi Kwang Ho
Published: November 2023

Intraoperative central venous catheter (CVC) insertion has become a routine procedure for pediatric cardiac surgery patients at our center. The case in which large amounts of pericardial effusion resulting in cardiac tamponade other than direct puncture of the catheter is a rare, but often causes fatal complications. Two of our patients suffered cardiac collapse after surgery owing to cardiac tamponade. Both the patients were successfully treated with pericardiocentesis, and the pericardial fluid had a high glucose level. Subsequently, the patients were discharged without any sequelae. During a serial radiographic follow-up, we found a pre-event alteration in the CVC angulation. These two cases highlight the fact that clinicians should pay attention to serial follow-up of chest radiography for monitoring any changes in the catheter status, such as its position or angulation, to prevent unexpected complications. The only way to prevent fatal complications due to CVC is timely recognition of any alteration in CVC based on radiological examinations. In instances of CVC changes, the issues should be addressed as quickly as possible.
Pengaruh Lingkungan Kerja, Budaya Kerja, Dan Beban Kerja Terhadap Kinerja Karyawan
Authors: Jodie Firjatullah  , Christian Wiradendi Wolor  , Marsofiyati Marsofiyati
Published: November 2023

This research has the objective of analyzing the relationship between the work environment, work culture and workload related to employee performance in an agency or company. This research uses quantitative methods through descriptive analysis, as well as online data collection using the Microsoft Forms Platform with a Likert scale of 1 to 5 with the Purposive Sampling method, there are 150 respondents with the age criteria 18-30 and currently working. Processed using the SmartPLS 4.0.9.2 application program. with Structural Eqution Modeling (SEM). The results showed that, the work environment is influential in supporting or improving the performance of its employees for the better and can produce quality work done by its employees. The work environment can be maximized when a company can implement or create a conducive, collaborative environment, and pay attention to all aspects such as the physical and psychological of its employees. Such factors as sufficient facilities, social support, and job security can increase employee performance productivity. Organizational work culture also plays an important role in shaping employee performance. Organizations with a culture that encourages innovation, collaboration, and employee motivation have better performance. Conversely, a work culture that does not support employees can hinder employee performance. Workload in accordance with individual capacity also affects employee performance. Too high a workload can lead to excessive stress and fatigue, which negatively impacts productivity. Therefore, wise management in determining workload is essential. From this study, it can be concluded that a good work environment, positive work culture, and workload adjustment can significantly improve employee performance. A company or an agency needs to pay attention to these factors to achieve optimal productivity and job satisfaction in the midst of intense competition between agencies.
APPLICATION OF EYE-TRACKING TECHNOLOGY DUAL EYE TRACKING (DUET) IN THE STUDY OF COOPERATION BETWEEN CHILDREN WITH ATYPICAL DEVELOPMENT AND ADULTS IN THE LEARNING PROCESS
Authors: Smirnova Yana
Published: November 2023

A technological breakthrough in simultaneously tracking the visual
behavior of two people with an eye tracker (DUET) allows you to explore
how a child perceives the world and how an adult (teacher) infl uences it. It
became possible to more objectively trace the transformation of a child’s perceptual
processes under the infl uence of learning (Monroy, Chen, Houston,
Yu, ). An analysis of the gaze movements allows us to model the learning
process as the emergence and dynamic transformation of an intersubjective
connection between the perception-action systems of a child and an adult
(Shvarts, ). Synchronous registration of the dyad’s eye movements was
carried out by two portable trackers in the form of Pupil Headset goggles. A
comparative study was carried out on a sample of preschoolers - years old:
typically developing children and children with hearing impairment after cochlear
implantation (sensoneural hearing loss, ICD- class H). An analysis
of the ways in which the gaze of the adult-child dyad moves makes it possible
to model the learning process as the emergence and dynamic transformation
of an intersubjective connection between the perception-action systems of
a child and an adult. Comparison of gaze patterns showed that contrasting
groups of children use different perceptual strategies in the learning process:
the specifi city of eye movements of contrasting groups is manifested in the
perceptual actions themselves and the pattern of eye movements relative to
fi xations in relevant areas corresponding to the task. It was found that the
oculomotor activity of an adult changes in the process of interaction with
children of contrasting groups and is organized taking into account the specifi
c features of the child’s perceptual activity. Differences are manifested in
the degree of synchrony of fi xations and the similarity of the trajectories of
gaze movements of an adult and a child. An important result of using the
DUET technology on contrast samples is the fact that the process of teaching/
learning caused a mutual transformation of the perceptual strategies of
both the adult and the child. The perceptual connection of the dyad is clearly
manifested in tracking, identifying and controlling perceptual actions as a
previous phase, the emergence of compatibility.
SOME ASPECTS OF DIGITAL SOCIALIZATION OF PRESCHOOL AND PRIMARY SCHOOL CHILDREN (RESULTS OF AN EMPIRICAL STUDY)
Authors: Smirnova Svetlana , Klopotova Ekaterina
Published: November 2023

Digital childhood is determined by a special social situation of
the development, since the persistent use of digital devices affects all spheres
of contemporary children’s life. The Center for Interdisciplinary Research on
Contemporary Childhood of MSUPE conducted an empirical study aimed at
identifying the peculiarities of parents’ position regarding the use of gadgets
by their children. Questionnaires were developed for parents of preschool
and primary school age children. The sample consisted of  respondents
from different regions of Russia. The data obtained suggest that most children
get access to digital devices at preschool age with the permission of
their parents, as a rule, for entertainment and the development of individual
mental functions. Digital devices begin to perform the socializing function at
primary school age, when the functionality of their use signifi cantly expands,
and they start being used to solve such age-related tasks as communication
and learning. Most Russian parents of preschoolers take a conscious position
regarding their children’s access to digital devices, allowing or completely
prohibiting children from using them. However, there are parents who lack
a consistent strategy in providing digital devices to their children. They have
diffi culties in organizing their children’s interaction with various types of
digital content. At the same time, parents rarely rely on professional recommendations
concerning the organization of the child’s interaction with digital
devices. The revealed contradiction emphasises the importance of elaborating
recommendations for organizing children’s interaction with digital
media as a tool that allows them to effectively solve socialization tasks.
IMPACT OF TEENAGERS’ INTERNET INVOLVEMENT ON THEIR EMOTIONAL INTELLIGENCE
Authors: Dudareva Alexandra
Published: November 2023

Modern teenagers are the fi rst generation whose adolescence
is directly linked to digital technology. The question of whether high Internet
activity has an impact on psychological and emotional development is
actively discussed among doctors, psychologists, and educators. Emotional
intelligence is linked to adolescent adaptation, psychological well-being, and
academic achievement. It has been found that teenagers with high levels of
emotional intelligence demonstrate more productive coping styles, and the
ability to understand and manage their emotions is a basic soft skill. The goal
of the study was to identify the relationship between the level of emotional
intelligence development and Internet involvement among teenagers. The
methods used were a questionnaire to determine the adolescent’s Internet
activity and the fi rst subtest of Guilford’s Test on Social Intelligence. The sample
consisted of  teenagers from th to th grades from different regions
of the Republic of Karelia. The results indicate a relationship between the
level of emotional intelligence development in teenagers and their Internet
involvement. It was found that the higher the child’s Internet involvement is,
the lower their emotional intelligence is. The data obtained during the study
suggest that to optimize work with teenagers, it is necessary to understand
that online interaction with them is currently the most effective format. This
is why it is important to develop programs for the development of emotional
intelligence for teenagers using the Internet. The research described in this
publication was made possible in part by R&D Support Program for undergraduate
and graduate students and postdoctoral researcher of PetrSU, funded
by the Government of the Republic of Karelia.
EXECUTIVE FUNCTIONS IN EARLY BILINGUAL SCHOOL-CHILDREN STUDYING A THIRD LANGUAGE
Authors: Novgorodova Yulia , Khotinets Vera , Kozhevnikova Oxana
Published: November 2023

The study is focused on the possibility to extrapolate the effects
of bilingualism on trilingualism at the primary school age, and of increasing /
decreasing cognitive regulation of bilingual children in the process and result
of learning other languages. The study involved  second-grade students
aged  to . years (M = ., SD = .). Among them  are primary schoolchildren
with unbalanced bilingualism (inherited Udmurt language) socializing
in the Udmurt-Russian environment; and  are monolinguals with native
Russian. To measure the components of cognitive regulation, NEPSY-II test
battery (Sentence Repetition, Memory for Designs, Inhibition) and computerized
tests (Stroop Test, Shulte Tables, Memory for geometric shapes, Go-No-
Go) were used. The mathematical and statistical analysis included descriptive
statistics, a non-parametric test (Mann-Whitney U-test) and Structural Equation
Modeling implemented with IBM SPSS Statistics V.. The results of
the pilot study confi rm the bilingual advantage in the process of learning a
third language by primary bilingual schoolchildren. In particular, the positive
effects of bilingualism on regulatory functions have been revealed, and, at
the same time, in the process of learning a third language bilingual primary
schoolchildren experience the increasing burden on the regulation of changes
in actions and behavior during the transition from one rule to another. Thus,
a possible syncretic (mixed) effect of bilingualism in the process of a third
language acquisition by primary schoolchildren with the need to control it in
an educational situation was revealed. We admit that bilingualism in the educational
situation of a third language acquisition as a predictor of cognitive
changes provides advantages in the self-organization of subsystems of regulatory
processes of the cognitive level and, along with this, creates diffi culties
due to the high regulatory load. The research was fi nancially supported by the
Russian Science Foundation (RSF) research project №--.
“RUSSIAN CHILDREN WELLBEING INDEX”: IMPLEMENTATION EXPERIENCE AND DEVELOPMENT PERSPECTIVES
Authors: Illarionova Elina
Published: November 2023

Today, available data on the situation of children do not allow us
to fully assess how well children live in Russia. The main directions of state
policy in the sphere of childhood protection base on the data, that not always
can accurately defi ne what actions will best suit the interest of each child.
One of the ways to better understand children real living standard in Russia
is to develop and implement Children Wellbeing Index, as an evidence-based
childhood policy tool. Children Wellbeing Index is the coordinated system of
descriptors for assessment of children living standards, based on the analysis
of two types of data: fi rst, regularly collected offi cial statistics, and, second,
the result of sociological survey of children themselves and their parents’
opinions. The report presents the experience of Elena and Gennady Timchenko
Charitable Foundation in creating of such an Index from preliminary
research of foreign Indices in - to the massive survey of   students
at the age of - and their parents in  regions of Russia in . The
report also covers the issues of creating and harmonizing the Index system,
which includes mutual verifi cation of the questionnaire and static parts, and
the ways in which the Fund plans to develop and implement the Index in the
future. The last part of report reveals possibilities of using the Index in evidence-
based decision-making in childhood sphere. The results are applied to
develop and gather best practices in improvement of some separate elements
of wellbeing at the level of regions; to create regional analytical centers; to
launch an education program about interpreting and using data for regional
offi cials, NGO-employees and different public representatives.
FEATURES OF INFERTILITY-RELATED STRESS EXPERIENCED BY WOMEN
Authors: Kargol Irina
Published: November 2023

Studies emphasize the role of infertility-related stress in the development
of infertility and the infl uence of psychological factors on success
of treatment. The purpose of the study was to investigate characteristics of
individual components of infertility-related stress such as anxiety, depression,
emotional schemas, and stress coping strategies. The data were collected
and processed with Beck Anxiety Inventory (BAI), Beck Depression Inventory
(BDI); Fertility Quality of Life (FertiQoL) Questionnaire (by J. Boivin);
Emotional Schemas Questionnaire II (LESS II) (by R.L. Leahy); and COPE
Stress Coping Questionnaire adapted by T.O. Gordeeva, E.N. Osin, et.al.,
Mann-Whitney U nonparametric test for statistical analysis. A sample of 
infertile women (the main group) and  women without infertility who
were not planning pregnancy in the near future (control group) participated
in the study. The study showed that the infertile women experience insuffi -
cient satisfaction with their quality of life, subjective emotional distress, lack
of social support, and some extent of marital dissatisfaction. Moreover, subclinical
levels of anxiety and depression are accompanied by general intensity
of emotional schemas and prevalence of such schemas as “Guilt about Emotions”,
“Incomprehensibility”, “Invalidation by Others”, “Predicted Duration
of Emotions”, “A Tendency to Ruminate”, “Simplistic View of Emotions”. In
stressful situations, the women experiencing infertility-related stress tend
to use behavioral strategies characterized by infl exibility, avoidance, denial,
and rare use of positive reframing or humor. The study revealed various
factors contributing to the infertility-related stress experienced by the infertile
women: insuffi cient satisfaction with their quality of life, subjective emotional
distress, lack of social support, and marital dissatisfaction. Moreover,
subclinical symptoms of anxiety and depression are accompanied by general
intensity of emotional schemas and a limited range of stress coping strategies.
SOCIAL-PSYCHOLOGICAL EFFECTS
OF REMOTE WORK IN PROFESSIONAL DEVELOPMENT
AND EDUCATION
Authors: Sheveleva Anna , Rogov Evgeniy
Published: November 2023

Introduction. The COVID- pandemic has forced many industrial
and educational organizations to switch to a remote approach. Although
remote work and education have some economic and organizational advantages,
there are also some potential «pitfalls» refl ected in the social activities,
personal development and team interactions. Methods. The method of
theoretical analysis of scientifi c and methodological sources in the fi elds of
social, educational and organizational psychology was used. The authors’
attention was focused on the remote forms of work and learning in “normal”
conditions, in contrast to the forced transition to remote activity while
providing anti-pandemic measures. Results. The socio-psychological effects
manifest in three directions: () interaction and communication, () formal
and informal groups and joint activities, () personal development. Interaction
and communication include the impact of digital technologies on the
information transfer within the teams and interpersonal contacts. The consequences
are increasing experience of isolation, virtual interaction with sense
of anonymity, text forms of communication. The decreasing phenomena are
role of visual non-verbal communication system and opportunities of feedback
giving and reception. Formal and informal groups experience decreasing
sense of group identity and cohesion, loyalty to educational organization
and involvement in joint activities, social support within the group or organization.
Some features of social activity expansion are multiple organizational
membership and educational mobility. The diffi culties in educational
administrating relate to organization and coordination of joint work and result
assessment. Personal manifestations are observed at the level of an individual
system of values and interests, goals setting and achieving, individual
behavior and subjective well-being, vocational choices and motives. Conclusion.
Summing up, we can offer some recommendations for organizational
and psychological support of learning, education and career counseling for
school students in order to minimize or compensate for the impact of negative socio-psychological effects of remote activity organization on learning
groups and individuals.
Analysis of Long-Term Contraception in Women of Childbearing Age on Mekarbakti Panongan Village Tangerang Regency in 2022
Authors: Azizah Iza Siti , Azzahroh Putri , Rukmaini
Published: November 2023

Background: One of the government's programs in family planning is the improvement of family planning services with long term contraception, but this was still hampered due to the high use of non-longterm contraception in Indonesia. Based on data from the Indonesian Ministry of Health, especially in Banten, it also shows that there is still a high use of non- long term contraception compared to long term contraception. The purpose of the study was to determine the relationship between age, occupation, knowledge, information on family planning services, husband support, culture, and attitudes of FAC women with the use of longterm contraception.
Purpose: This study aims to determine factors related with long-term contraceptive use on Mekarbakti Panongan sub-district, Tangerang Regency, Banten Province, in 2022.
Methods: The method used an analytical survey with a cross-sectional approach. The population in this study was all acceptors recorded in the family planning register located in the working area of Mekarbakti Panongan Village, Tangerang, who use long term contraception and those who do not use long term contraception, which is 1,984 acceptors. Sampling using accidental sampling, where 96 samples were obtained.
Results: Chi-square test results (0.05) for age sig-p value 0.050, work sig-p value 0.892, knowledge sig-p value 0.000, information by health workers sig-p value 0.014, husband support sig-p value 0.038, culture sig-p value 0.005, and attitude sig-p value 0.062.
Conclusion: In this study, there was an influence of age, knowledge, information provided by health workers, husband support, and culture on the selection of long term contraception, while occupational factors and attitudes did not have an influence on the selection of long term contraception.
L’ingénierie et ses mythes
Authors: Gaudin Olivier , Lerbet-Sereni Frédérique
Published: November 2023

Si la professionnalisation des métiers du social se fait de plus en plus
souvent selon le modèle d’une ingénierie de professionnalisation, quels imaginaires
sous-tendent ce mouvement ? Comment comprendre que le métier d’ingénieur, celui qui, au
moins dans l’imaginaire, invente et conçoit des machines au fonctionnement magiquement
prévisible, puisse être le modèle permettant de concevoir des dispositifs de formation aux
métiers de la relation ? Cette contribution propose d’explorer ces questions à travers deux
figures mythologiques souvent convoquées lorsqu’il est question d’ingénierie et de
technique : Prométhée, et Héphaïstos. Ces deux figures nous aideront à passer du modèle
d’une ingénierie de la professionnalisation à l’ingenium.
Former à, par ou pour la recherche, en ingénierie de formation : le cas d’un Master en formation d’adultes
Authors: Eneau Jérôme , Brémaud Loïc
Published: November 2023

Mises en place graduellement depuis 2002 et dans l’héritage du « Processus de Bologne » amorcé à la fin des années 1990, les réformes successives de l’enseignement universitaire, en France, ont profondément modifié le paysage des diplômes professionnels supérieurs. Les Diplômes d’Enseignement Supérieur Spécialisé (DESS), devenus des Masters professionnels, offrent un exemple paradigmatique des tensions entre les finalités anciennes de professionnalisation, à l’université, et celle d’un enseignement à, par ou pour la recherche, présent dans ces diplômes. Le cas du Master professionnel « Stratégie et Ingénierie en Formation d’Adultes » (SIFA), à l’université Rennes-2, permet d’illustrer cette problématique.
Single cell RNA-seq analysis of spinal locomotor circuitry in larval zebrafish
Authors: Kelly Jimmy J. , Wen Hua , Brehm Paul
Published: November 2023

Identification of the neuronal types that form the specialized circuits controlling distinct behaviors has benefited greatly from the simplicity offered by zebrafish. Electrophysiological studies have shown that additional to connectivity, understanding of circuitry requires identification of functional specializations among individual circuit components, such as those that regulate levels of transmitter release and neuronal excitability. In this study we use single cell RNA sequencing (scRNAseq) to identify the molecular bases for functional distinctions between motoneuron types that are causal to their differential roles in swimming. The primary motoneuron (PMn) in particular, expresses high levels of a unique combination of voltage-dependent ion channel types and synaptic proteins termed functional ‘cassettes’. The ion channel types are specialized for promoting high frequency firing of action potentials and augmented transmitter release at the neuromuscular junction, both contributing to greater power generation. Our transcriptional profiling of spinal neurons further assigns expression of this cassette to specific interneuron types also involved in the central circuitry controlling high speed swimming and escape behaviors. Our analysis highlights the utility of scRNAseq in functional characterization of neuronal circuitry, in addition to providing a gene expression resource for studying cell type diversity.
Hvordan kan simulering bidra til bevisstgjøring av utfordringer knyttet til legemiddelhåndtering i sykehjem?
Authors: Opheim Helene Margrethe Storebø , Arntzen Kari , Larsen Kristian
Published: November 2023

Bakgrunn: Simulering er en pedagogisk metode som kan benyttes for å tydeliggjøre sammensatte problemstillinger. Utfordringer knyttet til legemiddelhåndtering i ulike helseinstitusjoner inkludert sykehjem er kjent. Vi ønsket å se om simulering kunne være nyttig for å få frem ulike utfordringer som er knyttet til dette området. Hensikten med denne artikkelen er å beskrive sykepleieres og helsefagarbeideres erfaringer med å delta i simulering, og hvilke refleksjoner som oppstår rundt legemiddelhåndtering i sykehjem. Metode: Kvalitativ metode med fokusgruppeintervju. Resultater: Sykepleiere og helsefagarbeidere ble bevisst ulike utfordringer knyttet til legemiddelhåndtering ved hjelp av simulering. De fleste opplevde simuleringen som en nyttig metode i denne bevisstgjøringen. De fleste opplevde at de lærte noe som gav ny innsikt i egen arbeidssituasjon. Det var utfordringer knyttet til distraksjoner og stress, mangel på sykepleiere samt uklar ansvar- og oppgavefordeling. Konklusjon: Simulering som metode kan være bevisstgjørende for å synligjøre ulike utfordringer knyttet til legemiddelhåndtering i sykehjem.
Dex-Benchmark: datasets and code to evaluate algorithms for transcriptomics data analysis
Authors: Xie Zhuorui , Chen Clara , Ma’ayan Avi
Published: November 2023

Many tools and algorithms are available for analyzing transcriptomics data. These include algorithms for performing sequence alignment, data normalization and imputation, clustering, identifying differentially expressed genes, and performing gene set enrichment analysis. To make the best choice about which tools to use, objective benchmarks can be developed to compare the quality of different algorithms to extract biological knowledge maximally and accurately from these data. The Dexamethasone Benchmark (Dex-Benchmark) resource aims to fill this need by providing the community with datasets and code templates for benchmarking different gene expression analysis tools and algorithms. The resource provides access to a collection of curated RNA-seq, L1000, and ChIP-seq data from dexamethasone treatment as well as genetic perturbations of its known targets. In addition, the website provides Jupyter Notebooks that use these pre-processed curated datasets to demonstrate how to benchmark the different steps in gene expression analysis. By comparing two independent data sources and data types with some expected concordance, we can assess which tools and algorithms best recover such associations. To demonstrate the usefulness of the resource for discovering novel drug targets, we applied it to optimize data processing strategies for the chemical perturbations and CRISPR single gene knockouts from the L1000 transcriptomics data from the Library of Integrated Network Cellular Signatures (LINCS) program, with a focus on understudied proteins from the Illuminating the Druggable Genome (IDG) program. Overall, the Dex-Benchmark resource can be utilized to assess the quality of transcriptomics and other related bioinformatics data analysis workflows. The resource is available from: https://maayanlab.github.io/dex-benchmark.
Change in demand for health-related undergraduate studies in Spain during 2015–2021: a temporal series study
Authors: Jerez-Roig Javier , Bezerra de Souza Dyego L. , Cambra-Badii Irene , March-Amengual Jaume-Miquel , Comella Agustí , Masó-Aguado Montse , Ramon-Aribau Anna , Luque-Suárez Alejandro , Feito Grande Lydia , Terribas Núria , Vivanco Luis , Busquets-Alibés Ester
Published: November 2023

Introduction

The expansion of higher education is a worldwide phenomenon. To our knowledge, there are no studies analyzing the trends in demands of enrollment in health-related studies in Spain. Therefore, the objective was to analyze the change in demand (the number of requests for enrollment divided by the number of offered places) for undergraduate health-related studies in Spain during the period 2015–2021 as well as compare the change by region in the pre (2015–2019) and pandemic (2020–2021) period.

Methods

This is an observational (ecological type) study with temporal series analyses using data from public (non-for-profit) higher education institutions from the Integrated University Information System. For the analysis by region, we calculated the demand of all twelve undergraduate health-related degrees and the percentages of change between both periods using the Wilcoxon test. The Joinpoint Regression program was used to analyze the trends in demand for each degree during the 7-year period.

Results

Significant (p < 0.001) increases in demand during the pandemic period were observed in all regions. During the pandemic, medicine, biomedicine, nursing, odontology and pharmacy presented a higher demand in comparison with data collected before the pandemic started. In contrast, this pattern was not confirmed in the following cases: physiotherapy, occupational therapy, podiatry, psychology, social work, human nutrition and dietetics. By regions, Navarra, Asturias, and La Rioja presented the most drastic changes. In regions with the biggest number of universities, such as Catalonia, Andalusia and Madrid, the change observed was smaller.
Fluoroquinolone resistance determinants in carbapenem-resistant Escherichia coli isolated from urine clinical samples in Thailand
Authors: Boueroy Parichart , Chopjitt Peechanika , Hatrongjit Rujirat , Morita Masatomo , Sugawara Yo , Akeda Yukihiro , Iida Tetsuya , Hamada Shigeyuki , Kerdsin Anusak
Published: November 2023

Background

Escherichia coli is the most common cause of urinary tract infections and has fluoroquinolone (FQ)-resistant strains, which are a worldwide concern.

Objectives

To characterize FQ-resistant determinants among 103 carbapenem-resistant E. coli (CREc) urinary isolates using WGS.

Methods

Antimicrobial susceptibility, biofilm formation, and short-read sequencing were applied to these isolates. Complete genome sequencing of five CREcs was conducted using short- and long-read platforms.

Results

ST410 (50.49%) was the predominant ST, followed by ST405 (12.62%) and ST361 (11.65%). Clermont phylogroup C (54.37%) was the most frequent. The genes NDM-5 (74.76%) and CTX-M-15 (71.84%) were the most identified. Most CREcs were resistant to ciprofloxacin (97.09%) and levofloxacin (94.17%), whereas their resistance rate to nitrofurantoin was 33.98%. Frequently, the gene aac(6′)-Ib (57.28%) was found and the coexistence of aac(6′)-Ib and blaCTX-M-15 was the most widely predominant. All isolates carried the gyrA mutants of S83L and D87N. In 12.62% of the isolates, the coexistence was detected of gyrA, gyrB, parC, and parE mutations. Furthermore, the five urinary CREc-complete genomes revealed that blaNDM-5 or blaNDM-3 were located on two plasmid Inc types, comprising IncFI (60%, 3/5) and IncFI/IncQ (40%, 2/5). In addition, both plasmid types carried other resistance genes, such as blaOXA-1, blaCTX-M-15, blaTEM-1B, and aac(6′)-Ib. Notably, the IncFI plasmid in one isolate carried three copies of the blaNDM-5 gene.

Conclusions

This study showed FQ-resistant determinants in urinary CREc isolates that could be a warning sign to adopt efficient strategies or new control policies to prevent further spread and to help in monitoring this microorganism.
Time Series Intervention Modelling Based on ESM and ARIMA Models: Daily Pakistan Rupee/Nigerian Naira Exchange Rate
Authors: Inyang Elisha J. , Etuk Ette H. , Nafo Ngia M. , Da-Wariboko Yvonne A.
Published: November 2023

The battered Nigerian economy has slipped into its second economic recession in five years due to the fallout of the coronavirus pandemic. And this has had a remarkable effect on the value of the Nigerian Naira that are exchanged for a unit of many other currencies of the world. Intervention modelling is used to assess the impact of this external event on the Pakistan Rupee to the Nigerian Naira exchange rates. The dataset for this study is the daily Nigerian Naira exchange rate with respect to the Pakistan Rupee from January–December 2020. The intervention point is marked on April 10, 2020, as a pulse function for the PKR/NGN series. Results revealed that the economic recession due to the fallout of the coronavirus pandemic increased the value of the Nigerian Naira by 3.38% against the Pakistan Rupee, which 1PKR is exchanged for 2.2042NGN compared to the periods before and after the intervention occurred. The intervention was felt at the point of intervention itself but the effect dies immediately after the intervention. Hence, the intervention response is described as an abrupt start and abrupt decay.
Determination of Anti-oxidant Activity of Ethanol, Ethyl acetate, Hexane, and Aqueous Extracts of Sri Lankan Traditional Poly-herbal Formula Nāgarādi Panchakaya
Authors: Waratenne P. R.  , Jayasiri A. P. A.  , Manuha I. M.
Published: November 2023

Natural products are the good source of natural antioxidants. Nāgarādi panchakaya is a well-known poly-herbal formula prescribed specially for upper respiratory tract diseases by Sri Lankan Ayurveda medical practitioners. The name implies that it contains five herbal ingredients including Inguru (Zingiber officinale), Devadāra (Cedrus deodara), Kottammalli (Coriandrum sativum), Ela batu (Solanum indicum) and Katuwelbatu (Solanum xanthocarpum). This research study was aimed to determine the antioxidant activity of Nāgarādi panchakaya, extracted with different solvents (ethanol, ethyl acetate, n-hexane and water). Antioxidant activity was evaluated by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay method and the Ferric Reducing Antioxidant Power (FRAP) assay. In vitro antioxidant free radicals scavenging capacities of different concentrations of ethanol, ethyl acetate, n-hexane and water extracts, of Nāgarādi panchakaya were evaluated. The percentage of inhibition and IC50 were calculated. IC50 (μg/mL) of water, ethanol, ethyl acetate, n-hexane and Ascorbic Acid were found to be 179.89±1.25 µg /mL, 248.09±1.74 µg /mL, 169.43± 0.98µg /mL, 189.56±2.23 µg /mL, and 01.18±0.98 µg /mL respectively in DPPH radical scavenging assay. In FRAP assay the reducing power for the different extracts varied in following order: water > ethanol > ethyl acetate > n-hexane. The total Phenolic content of water, ethanol, ethyl acetate and n-hexane extracts were 1.73±0.51 mg GAE/g, 2.59±0.67 mg GAE/g, 3.67±0.81 mg GAE/g and 1.57±0.09 mg GAE/g respectively. The results can be concluded that Ethanol & water extracts exhibit high antioxidant activity possibly due to the presence of high phenolic content than the other extracts.
Performance of Plant Spacing Using Cut Seed Tubers of Different Varieties on Growth Parameters, Yield Attributes and Yield
Authors: Dagar Sandeep , Panghal V. P. S. , Vats Chaman , Asha  , Fandan Renu , Kumar Sunil , Akash
Published: November 2023

Aim: Potato is one of the most prominent crops to eliminate hunger and poverty at the global level. It is one of the world's most widely consumed and important food crops, providing a significant portion of the world's dietary energy and nutrients.

Methodology: The study was carried out at the research farm of Vegetable Science, Chaudhary Charan Singh Haryana Agricultural University- Hisar, India during the rabi season of the year 2021-22. The field experiment was conducted in a split-plot design with three potato varieties (Kufri Neelkanth, Kufri Bahar and Kufri Lima) and four different spacing (60×10 cm, 60×15 cm, 60×20 cm with cut tuber and 60×20 cm with whole tuber).

Results: Among different spacings and varieties, spacing 60×20 cm with whole tuber and Kufri Neelkanth was found best for plant height at 60, 75 and 90 days after planting, number of leaves/hill, leaves weight/hill (g), stem weight/hill (g), weight of fresh foliage (kg/m2) and and total tuber yield (q/ha), biological yield (q/ha), respectively. Whereas, Kufri Bahar was found maximum for the number of stems/hill (7.22) and Kufri Lima for total marketable tuber yield (374.4 q/ha).

Conclusion: The present study opens up new doors to the farmers and researchers for sustainable production of potatoes. The findings can be useful for farmers and researchers in developing effective strategies for improving the production of potato, which can have significant economic and nutritional benefits.
Trends in Use of Laparoscopic Intraperitoneal Onlay Mesh for Ventral Hernia Repair
Authors: Henriksen Nadia A. , Jensen Kristian K.
Published: November 2023

This cohort study examines changes in the proportion of laparoscopic intraperitoneal onlay mesh procedures performed for hernia repair in Denmark since initial description of the procedure.
Depletion Type Organic Electrochemical Transistors and the Gradual Channel Approximation
Authors: Skowrons Michael , Dahal Drona , Paudel Pushpa Raj , Lüssem Björn
Published: November 2023

The gradual channel approximation forms the foundation for the analysis of field‐effect transistors. It has been used to discuss transistors that are not necessarily based on the field‐effect as well, such as the organic electrochemical transistor (OECT). Here, the applicability of the gradual channel approximation for OECTs is studied by a 2D drift‐diffusion model. It is found that OECT switching can be described by two separate effects—a doping/dedoping mechanism and the formation of an electrostatic double layer at the interface between the mixed conductor and the electrolyte. The balance between these two mechanisms is determined by the morphology of the mixed conductor, in particular the question if ions move in the same phase and electric potential as the holes, or if separate ion and hole phases are formed. It is argued that the gradual channel approximation can only be used to describe electrostatic switching at the mixed conductor/electrolyte interface (the two‐phase model), but cannot be employed to analyze devices operating on a doping/de‐doping mechanism (the one‐phase model).
Post‐Synthetic Modification of Aerogels Made of Covalent Cross‐linked Metal‐Organic Polyhedra
Authors: Khobotov‐Bakishev Akim , Samanta Partha , Roztocki Kornel , Albalad Jorge , Royuela Sergio , Furukawa Shuhei , Zamora Félix , Carné‐Sánchez Arnau , Maspoch Daniel
Published: November 2023

Aerogels are porous ultralight materials known for their high porosity, wide range of pore sizes, low density, and good macroscopic mechanical properties, all of which make them promising candidates for shaped adsorbents, catalysts, and insulators, among other applications. Here, this work reports a new approach that enables both the formation of modular aerogels, via dynamic covalent chemistry, and their post‐synthetic modification, via coordination chemistry. To demonstrate this strategy, this work first polymerizes porous amino‐functionalized Rh(II)‐based metal‐organic polyhedra (MOPs) with aldehydes, which afforded robust imine‐gel networks that is then converted into aerogels. Next, this work functionalizes these aerogels through the coordination of ligands on the axial site of Rh(II) paddlewheels of the MOP. Interestingly, in this chemistry, the local changes in the coordination site of the MOPs are transferred to the overall aerogel, thereby altering its macroscopic physicochemical properties. Importantly, this feature enables the synthesis of optimized adsorbents tailored to specific guests, as this work demonstrates through a series of experiments using ligands of different electrostatic and hydrophobic characters.
Functional Hydrogel Co‐Remolding Migration and Differentiation Microenvironment for Severe Spinal Cord Injury Repair
Authors: Liu Dingyang , Shen He , Zhang Kai , Shen Yeyu , Wen Runlin , He Xinghui , Long Ge , Li Xing
Published: November 2023

Spinal cord injury (SCI) activates nestin+ neural stem cells (NSCs), which can be regarded as potential seed cells for neuronal regeneration. However, the lesion microenvironment seriously hinders the migration of the nestin+ cells to the lesion epicenter and their differentiation into neurons to rebuild neural circuits. In this study, a photosensitive hydrogel scaffold is prepared as drug delivery carrier. Genetically engineered SDF1α and NT3 are designed and the scaffold is binary modified to reshape the lesion microenvironment. The binary modified scaffold can effectively induce the migration and neuronal differentiation of nestin+ NSCs in vitro. When implanted into a rat complete SCI model, many of the SCI‐activated nestin+ cells migrate into the lesion site and give rise to neurons in short‐term. Meanwhile, long‐term repair results also show that implantation of the binary modified scaffold can effectively promote the maturation, functionalization and synaptic network reconstruction of neurons in the lesion site. In addition, animals treated with binary scaffold also showed better improvement in motor functions. The therapeutic strategy based on remolding the migration and neuronal differentiation lesion microenvironment provides a new insight into SCI repair by targeting activated nestin+ cells, which exhibits excellent clinical transformation prospects.
Reducing Perovskite/C60 Interface Losses via Sequential Interface Engineering for Efficient Perovskite/Silicon Tandem Solar Cell
Authors: Liu Zhou , Li Hongjiang , Chu Zijing , Xia Rui , Wen Jin , Mo Yi , Zhu Hesheng , Luo Haowen , Zheng Xuntian , Huang Zilong , Luo Xin , Wang Bo , Zhang Xueling , Yang Guangtao , Feng Zhiqiang , Chen Yifeng , Kong Wenchi , Gao Jifan , Tan Hairen
Published: November 2023

Wide‐bandgap (WBG) perovskite solar cells hold tremendous potential for realizing efficient tandem solar cells. However, nonradiative recombination and carrier transport losses occurring at the perovskite/electron‐selective contact (e.g. C60) interface present significant obstacles in approaching their theoretical efficiency limit. To address this, a sequential interface engineering (SIE) strategy that involves the deposition of ethylenediamine diiodide (EDAI2) followed by sequential deposition of 4‐Fluoro‐Phenethylammonium chloride (4F‐PEACl) is implemented. The SIE technique synergistically narrows the conduction band offset and reduces recombination velocity at the perovskite/C60 interface. The best‐performing WBG perovskite solar cell (1.67 eV) delivers a power conversion efficiency (PCE) of 21.8% and an impressive open‐circuit voltage of 1.262 V. Moreover, through integration with double‐textured silicon featuring submicrometer pyramid structures, a stabilized PCE of 29.6% is attained for a 1 cm2 monolithic perovskite/silicon tandem cell (certified PCE of 29.0%).
Diffusible Capping Layer Enabled Homogeneous Crystallization and Component Distribution of Hybrid Sequential Deposited Perovskite
Authors: Xu Qiaojing , Shi Biao , Li Yucheng , Liu Jingjing , Li Yuxiang , SunLi Zetong , Liu Pengfei , Zhang Yubo , Sun Cong , Han Wei , Huang Qian , Zhang Dekun , Ren Huizhi , Du Xiaona , Zhao Ying , Zhang Xiaodan
Published: November 2023

Nowadays, the development of wide‐bandgap perovskite by thermal evaporation and spin‐coating hybrid sequential deposition (HSD) method has special meaning on textured perovskite/silicon tandem solar cells. However, the common issues of insufficient reaction caused by blocking of perovskite capping layer are exacerbated in HSD, because evaporated precursors are usually denser with higher crystallinity and the widely used additive‐assisted microstructure is also difficult to access. Here, a facile “diffusible perovskite capping layer” (DPCL) strategy to solve this dilemma is presented. With DPCL, crystallization alleviation of perovskite and more diffusion channels of organic salts can be realized simultaneously, contributing to a homogenization process. The resultant perovskite films exhibit complete conversion, uniform crystallization, enhanced quality, and reduced defect, leading to obvious improvements in device efficiency, repeatability, and stability. This work offers a way to promote the development of textured tandems a step further.
High Output Power and High Quantum Efficiency in Novel NIR Phosphor MgAlGa0.7B0.3O4:Cr3+ with Profound FWHM Variation
Authors: Zhong Chuansheng , Xu Yonghui , Wu Xiudi , Yin Shuwen , Zhang Xibao , Zhou Liang , You Hongpeng
Published: November 2023

There is strong demand for ultraefficient near‐infrared (NIR) phosphors with adjustable emission properties for next‐generation intelligent NIR light sources. Designing phosphors with large full‐width at half‐maximum (FWHM) variations is challenging. In this study, novel near‐ultraviolet light‐emitting diode (LED)‐excited NIR phosphors, MgAlGa0.7B0.3O4:Cr3+ (MAGBO:Cr3+), with three emission centers achieve ultra‐narrowband (FWHM = 29 nm) to ultra‐broadband (FWHM = 260 nm) emission with increasing Cr3+ concentration. Gaussian fitting and decay time analysis reveal the alteration in the FWHM, which is attributed to the energy transfer occurring between the three emission centers. The distinct thermal quenching behaviors of the three emission centers are revealed through the temperature‐dependent decay times. The ultra‐broadband NIR phosphor MAGBO:0.05Cr3+ exhibits high thermal stability (85%, 425 K) and exceptional external quantum efficiency of 68.5%. An NIR phosphor‐converted LED (pc‐LED) is fabricated using MAGBO:0.05Cr3+ phosphor, exhibiting a remarkable NIR output power of 136 mW at 600 mA in ultra‐broadband NIR pc‐LEDs. This study describes the preparation of highly efficient phosphors and provides a further understanding of the tunable FWHM, which is vital for high‐performance NIR phosphors with versatile applications.
Ultrathin Clay Nanoparticles‐Mediated Mutual Reinforcement of Ferroptosis and Cancer Immunotherapy
Authors: Liu Jianping , Zhan Jiezhao , Zhang Ye , Huang Lin , Yang Jing , Feng Jie , Ding Lingwen , Shen Zheyu , Chen Xiaoyuan
Published: November 2023

Ferroptosis‐triggered immunogenic cell death (ICD) is widely adopted to potentiate the body's antitumor immunity by catalyzing the production of toxic reactive oxygen species (ROS). However, the efficacy of ferroptosis and immunotherapy is greatly restricted by intracellular abundant glutathione (GSH) and immunosuppressive tumor microenvironment (TME). Herein, a facile bottom‐up method for solvent‐free synthesis of ultrathin manganese (Mn)‐based layered double hydroxide nanosheets with high loading efficiency for pro‐inflammatory cytokine interferon (IFNγ) (IFNγ/uMn‐LDHs) is proposed to mutually reinforce the ferroptosis and systemic immunity. The introduction of manganese ions significantly contributes to GSH depletion and hydroxyl radical generation, which can be further enhanced by IFNγ delivery‐induced SLC7A11 downregulation. The ICD effect after cell ferroptosis cooperates with the intrinsic immunomodulatory property of IFNγ/uMn‐LDHs to facilitate the maturation of dendritic cells (DCs) and the priming of T cells. IFNγ secretion from activated CD8+ T cells in turn involves cascade immunogenic ferroptosis, thus constructing a closed‐loop therapy. Remarkably, a potent abscopal effect is observed in the growth inhibition of both primary and distant tumors. Overall, the ultrathin Mn‐based clay nanoplatform provides a simple approach for mutual regulation between ferroptosis and antitumor immune response, overcoming the obstacles of current cancer immunotherapy.