bluuebunny/crossref_metadata_2025 huggingface dataset:
A Panel-Agnostic Strategy ‘HiPPo’ Improves Diagnostic Efficiency in the UK Genomic Medicine Service
Authors: Seaby Eleanor G. , Thomas N. Simon , Hunt David , Baralle Diana , Rehm Heidi L. , O’Donnell-Luria Anne , Ennis Sarah
Published: December 2023

Genome sequencing is available as a clinical test in the UK through the Genomic Medicine Service (GMS). The GMS analytical strategy predominantly filters genome data on preselected gene panels. Whilst this reduces variants requiring assessment by reporting laboratories, pathogenic variants outside applied panels may be missed, and variants in genes without established disease–gene relationships are largely ignored. This study compares the analysis of a research exome to a GMS clinical genome for the same patients. For the research exome, we applied a panel-agnostic approach filtering for variants with High Pathogenic Potential (HiPPo) using ClinVar, allele frequency, and in silico prediction tools. We then restricted HiPPo variants to Gene Curation Coalition (GenCC) disease genes. These results were compared with the GMS genome panel-based approach. Twenty-four participants from eight families underwent parallel research exome and GMS genome sequencing. Exome HiPPo analysis identified a similar number of variants as the GMS panel-based approach. GMS genome analysis returned two pathogenic variants and one de novo variant. Exome HiPPo analysis returned the same variants plus an additional pathogenic variant and three further de novo variants in novel genes, where case series are underway. When HiPPo was restricted to GenCC disease genes, statistically fewer variants required assessment to identify more pathogenic variants than reported by the GMS, giving a diagnostic rate per variant assessed of 20% for HiPPo versus 3% for the GMS. With UK plans to sequence 5 million genomes, strategies are needed to optimise genome analysis beyond gene panels whilst minimising the burden of variants requiring clinical assessment.
Machine-Learning-Based Forest Classification and Regression (FCR) for Spatial Prediction of Liver Fluke Opisthorchis viverrini (OV) Infection in Small Sub-Watersheds
Authors: Pumhirunroj Benjamabhorn , Littidej Patiwat , Boonmars Thidarut , Bootyothee Kanokwan , Artchayasawat Atchara , Khamphilung Phusit , Slack Donald
Published: December 2023

Infection of liver flukes (Opisthorchis viverrini) is partly due to their suitability for habitats in sub-basin areas, which causes the intermediate host to remain in the watershed system in all seasons. The spatial monitoring of fluke at the small basin scale is important because this can enable analysis at the level of the factors involved that influence infections. A spatial mathematical model was weighted by the nine spatial factors X1 (index of land-use types), X2 (index of soil drainage properties), X3 (distance index from the road network, X4 (distance index from surface water resources), X5 (distance index from the flow accumulation lines), X6 (index of average surface temperature), X7 (average surface moisture index), X8 (average normalized difference vegetation index), and X9 (average soil-adjusted vegetation index) by dividing the analysis into two steps: (1) the sub-basin boundary level was analyzed with an ordinary least square (OLS) model used to select the spatial criteria of liver flukes aimed at analyzing the factors related to human liver fluke infection according to sub-watersheds, and (2) we used the infection risk positional analysis level through machine-learning-based forest classification and regression (FCR) to display the predictive results of infection risk locations along stream lines. The analysis results show four prototype models that import different independent variable factors. The results show that Model 1 and Model 2 gave the most AUC (0.964), and the variables that influenced infection risk the most were the distance to stream lines and the distance to water bodies; the NDMI and NDVI factors rarely affected the accuracy. This FCR machine-learning application approach can be applied to the analysis of infection risk areas at the sub-basin level, but independent variables must be screened with a preliminary mathematical model weighted to the spatial units in order to obtain the most accurate predictions.
Exploring the Structure and Properties of VwSeyTe2−y Mixed Crystals in the VTe2–VSe2 System
Authors: Kurig Sophia , Ketter Fabian , Frommelius Anne , Hakala B. Viliam , van Leusen Jan , Friese Karen , Dronskowski Richard
Published: December 2023

Vanadium (IV) chalcogenide materials are of increasing interest for use in catalysis and energy conversion-related applications. Since no ternary compounds are yet known in the V–Se–Te system, we studied ternary VwSeyTe2−y (w = 1.10, 1.13; y = 0.42, 0.72) phases crystallizing in space group P3¯m1 (no. 164). Two single-crystal specimens with differing compositions of a solid solution were obtained using the ceramic method. All products were characterized by either single-crystal or powder X-ray diffraction. The lattice parameters increase with rising tellurium content in accordance with the larger ionic radius of the tellurium anion compared to selenium. The chemical compositions were confirmed by energy-dispersive X-ray spectroscopy. Furthermore, magnetic measurements mostly revealed antiferromagnetic properties. Simultaneous differential scanning calorimetry/thermogravimetric analyses in a nitrogen atmosphere showed endothermic decomposition accompanied by the formation of VN. The decomposition of VSe and VTe was observed in an argon atmosphere. The results of this work can serve as a basis for the synthesis of new phases in the V–Se–Te and related vanadium chalcogenide systems.
Additive Manufacturing of Side-Coupled Cavity Linac Structures from Pure Copper: A First Concept
Authors: Mayerhofer Michael , Brenner Stefan , Helm Ricardo , Gruber Samira , Lopez Elena , Stepien Lukas , Gold Gerald , Dollinger Günther
Published: December 2023

Compared to conventional manufacturing, additive manufacturing (AM) of radio frequency (RF) cavities has the potential to reduce manufacturing costs and complexity and to enable higher performance. This work evaluates whether normal conducting side-coupled linac structures (SCCL), used worldwide for a wide range of applications, can benefit from AM. A unit cell geometry (SC) optimized for 75 MeV protons was developed. Downskins with small downskin angles α were avoided to enable manufacturing by laser powder bed fusion without support structures. SCs with different α were printed and post-processed by Hirtisation (R) (an electrochemical process) to minimize surface roughness. The required accuracy for 3 GHz SCCL (medical linacs) is achieved only for α>45∘. After a material removal of 140 µm due to Hirtisation (R), a quality factor Q0 of 6650 was achieved. This corresponds to 75% of the Q0 simulated by CST®. A 3 GHz SCCL concept consisting of 31 SCs was designed. The effective shunt impedance ZT2 simulated by CST corresponds to 60.13MΩm and is comparable to the ZT2 of SCCL in use. The reduction in ZT2 expected after Hirtisation (R) can be justified in practice by up to 70% lower manufacturing costs. However, future studies will be conducted to further increase Q0.
Pancreaticoduodenectomies with Concurrent Colectomies: Indications, Technical Issues, Complications, and Oncological Outcomes
Authors: Dumitrascu Traian
Published: December 2023

Multi-visceral resections for colon and pancreatic cancer (PDAC) are feasible, safe, and justified for early and late outcomes. However, the use of pancreaticoduodenectomy (PD) with concurrent colectomies is highly debatable in terms of morbidity and oncological benefits. Based on current literature data, this review assesses the early and long-term outcomes of PD with colectomies. The association represents a challenging but feasible option for a few patients with PDAC or locally advanced right colon cancer when negative resection margins are anticipated because long-term survival can be achieved. Concurrent colectomies during PD should be cautiously approached because they may significantly increase complication rates, including severe ones. Thus, patients should be fit enough to overcome potential severe complications. Patients with PD and colectomies can be classified as borderline resectable, considering the high risk of developing postoperative complications. Carefully selecting patients suitable for PD with concurrent colectomies is paramount to mitigate the potentially severe complications of the two surgical procedures and maximize the oncological benefits. These procedures should be performed at high-volume centers with extensive experience in pancreatectomies and colectomies, and each patient situation should be assessed using a multimodal approach, including high-quality imaging and neoadjuvant therapies, in a multidisciplinary team discussion.
Imaging in Third Molar Surgery: A Clinical Update
Authors: Al-Haj Husain Adib , Stadlinger Bernd , Winklhofer Sebastian , Bosshard Fabienne A. , Schmidt Valérie , Valdec Silvio
Published: December 2023

Third molar surgery is one of the most common surgical procedures performed in oral and maxillofacial surgery. Considering the patient’s young age and the often-elective nature of the procedure, a comprehensive preoperative evaluation of the surgical site, relying heavily on preoperative imaging, is key to providing accurate diagnostic work-up, evidence-based clinical decision making, and, when appropriate, indication-specific surgical planning. Given the rapid developments of dental imaging in the field, the aim of this article is to provide a comprehensive, up-to-date clinical overview of various imaging techniques related to perioperative imaging in third molar surgery, ranging from panoramic radiography to emerging technologies, such as photon-counting computed tomography and magnetic resonance imaging. Each modality’s advantages, limitations, and recent improvements are evaluated, highlighting their role in treatment planning, complication prevention, and postoperative follow-ups. The integration of recent technological advances, including artificial intelligence and machine learning in biomedical imaging, coupled with a thorough preoperative clinical evaluation, marks another step towards personalized dentistry in high-risk third molar surgery. This approach enables minimally invasive surgical approaches while reducing inefficiencies and risks by incorporating additional imaging modality- and patient-specific parameters, potentially facilitating and improving patient management.
Diagnostics, Management, and Outcomes in Patients with Pyogenic Spinal Intra- or Epidural Abscess
Authors: Hijazi Mido Max , Siepmann Timo , El-Battrawy Ibrahim , Aweimer Assem , Engellandt Kay , Podlesek Dino , Schackert Gabriele , Juratli Tareq A. , Eyüpoglu Ilker Y. , Filis Andreas
Published: December 2023

Background: Owing to the lack of evidence on the diagnostics, clinical course, treatment, and outcomes of patients with extremely rare spinal intradural abscess (SIA) and spinal epidural abscess (SEA), we retrospectively analyzed and compared a cohort of patients to determine the phenotyping of both entities. Methods: Over a period of 20 years, we retrospectively analyzed the electronic medical records of 78 patients with SIA and SEA. Results: The patients with SIA showed worse motor scores (MS scores) on admission (SIA: 20 ± 26 vs. SEA: 75 ± 34, p < 0.001), more often with an ataxic gait (SIA: 100% vs. SEA: 31.8%, p < 0.001), and more frequent bladder or bowel dysfunction (SIA: 91.7% vs. SEA: 27.3%, p < 0.001) compared to the SEA patients. Intraoperative specimens showed a higher diagnostic sensitivity in the SEA patients than the SIA patients (SIA: 66.7% vs. SEA: 95.2%, p = 0.024), but various pathogens such as Staphylococcus aureus (SIA 33.3% vs. SEA: 69.4%) and Streptococci and Enterococci (SIA 33.3% vs. SEA: 8.1%, p = 0.038) were detected in both entities. The patients with SIA developed sepsis more often (SIA: 75.0% vs. SEA: 18.2%, p < 0.001), septic embolism (SIA: 33.3% vs. SEA: 8.3%, p = 0.043), signs of meningism (SIA: 100% vs. 18.5%, p < 0.001), ventriculitis or cerebral abscesses (SIA: 41.7% vs. SEA: 3.0%, p < 0.001), and pneumonia (SIA: 58.3% vs. SEA: 13.6%, p = 0.002). The mean MS score improved in both patient groups after surgery (SIA: 20 to 35 vs. SEA: 75 to 90); however, the SIA patients showed a poorer MS score at discharge (SIA: 35 ± 44 vs. SEA: 90 ± 20, p < 0.001). C-reactive protein (CrP) (SIA: 159 to 49 vs. SEA: 189 to 27) and leukocyte count (SIA: 15 to 9 vs. SEA: 14 to 7) were reduced at discharge. The SIA patients had higher rates of disease-related mortality (SIA: 33.3% vs. SEA: 1.5%, p = 0.002), had more pleural empyema (SIA: 58.3% vs. SEA: 13.6%, p = 0.002), required more than one surgery (SIA: 33.3% vs. SEA 13.6%, p = 0.009), were treated longer with intravenous antibiotics (7 ± 4 w vs. 3 ± 2 w, p < 0.001) and antibiotics overall (12 ± 10 w vs. 7 ± 3 w, p = 0.022), and spent more time in the hospital (SIA: 58 ± 36 vs. SEA: 26 ± 20, p < 0.001) and in the intensive care unit (SIA: 14 ± 18 vs. SEA: 4 ± 8, p = 0.002). Conclusions: Our study highlighted distinct clinical phenotypes and outcomes between both entities, with SIA patients displaying a markedly less favorable disease course in terms of complications and outcomes.
Pharmacogenomic Considerations for Anticoagulant Prescription in Patients with Hereditary Haemorrhagic Telangiectasia
Authors: McCarley Sarah , Murphy Daniel , Thompson Jack , Shovlin Claire
Published: December 2023

Hereditary haemorrhagic telangiectasia (HHT) is a vascular dysplasia that commonly results in bleeding but with frequent indications for therapeutic anticoagulation. Our aims were to advance the understanding of drug-specific intolerance and evaluate if there was an indication for pharmacogenomic testing. Genes encoding proteins involved in the absorption, distribution, metabolism, and excretion of warfarin, heparin, and direct oral anticoagulants (DOACs) apixaban, rivaroxaban, edoxaban, and dabigatran were identified and examined. Linkage disequilibrium with HHT genes was excluded, before variants within these genes were examined following whole genome sequencing of general and HHT populations. The 44 genes identified included 5/17 actionable pharmacogenes with guidelines. The 76,156 participants in the Genome Aggregation Database v3.1.2 had 28,446 variants, including 9668 missense substitutions and 1076 predicted loss-of-function (frameshift, nonsense, and consensus splice site) variants, i.e., approximately 1 in 7.9 individuals had a missense substitution, and 1 in 71 had a loss-of-function variant. Focusing on the 17 genes relevant to usually preferred DOACs, similar variant profiles were identified in HHT patients. With HHT patients at particular risk of haemorrhage when undergoing anticoagulant treatment, we explore how pre-emptive pharmacogenomic testing, alongside HHT gene testing, may prove beneficial in reducing the risk of bleeding and conclude that HHT patients are well placed to be at the vanguard of personalised prescribing.
Total Ankle Replacement Infections: A Systematic Review of the Literature
Authors: Zunarelli Renato , Fiore Michele , Lonardo Gianluca , Pace Andrea , Persiani Valentina , De Paolis Massimiliano , Sambri Andrea
Published: December 2023

Periprosthetic infection (PJI) after TAR is a serious complication, often requiring further surgery, including revision arthroplasty, conversion to ankle arthrodesis, or even amputation. This systematic review aims to summarize the current evidence on the management of TAR PJI and provide a comprehensive overview of this topic, especially from an epidemiologic point of view. Three different databases (PubMed, Scopus, and Web of Science) were searched for relevant articles, and further references were obtained by cross-referencing. Seventy-one studies met the inclusion criteria, reporting on cases of TAR PJI. A total of 298 PJIs were retrieved. The mean incidence of PJI was 3.8% (range 0.2–26.1%). Furthermore, 53 (17.8%) were acute PJIs, whereas most of them (156, 52.3%) were late PJIs. Most of the studies were heterogeneous regarding the treatment protocols used, with a two-stage approach performed in most of the cases (107, 35.9%). While the prevalence of ankle PJI remains low, it is potentially one of the most devastating complications of TAR. This review highlights the lack of strong literature regarding TAR infections, thus highlighting a need for multicentric studies with homogeneous data regarding the treatment of ankle PJI to better understand outcomes.
Cytology Techniques Can Provide Insight into Human Placental Structure Including Syncytiotrophoblast Nuclear Spatial Organisation
Authors: Fives Cassie , Toulouse André , Kenny Louise , Brosnan Therese , McCarthy Julie , Fitzgerald Brendan
Published: December 2023

The aim of this study was to provide the first systematic description of human placental cytology appearances and to investigate syncytiotrophoblast nuclear organisation patterns using cytology techniques. Term placentas from normal pregnancies were sampled using fine-needle aspiration (FNA) and direct scrapes. Standard histological examination was also performed to exclude pathological changes in the placentas being studied. Both Papanicolaou-stained cytospin preparations and air-dried Giemsa slides from FNA provided high-quality material for cytological assessment with good cellularity. Among the key features of the cytology preparations were villous “microbiopsies” that allowed for the three-dimensional appreciation of villous branching patterns. Cytological appearances, including nuclear characteristics of villous cytotrophoblast and syncytiotrophoblast, were also well demonstrated. In microbiopsies and detached villous trophoblast sheets, complex patterns of syncytiotrophoblast nuclear organisation, not previously described cytologically, were observed, including irregular spacing of nuclei, syncytioplasm windows and linear nuclear arrangements. This study showed that placental cytology (a) provides technically excellent material for cytological evaluation, (b) confirms the presence of complex nuclear organisational patterns in the syncytiotrophoblast by eliminating the possibility of tangential sectioning artefact, (c) provides superior nuclear detail over standard histological sections and (d) may be an untapped research resource for the investigation of normal and pathological processes because of its ability to look at the placenta in a novel way and through its potential for both ex vivo and in vivo placental sampling.
Convolutional Neural Network Model for Segmentation and Classification of Clear Cell Renal Cell Carcinoma Based on Multiphase CT Images
Authors: Bolocan Vlad-Octavian , Secareanu Mihaela , Sava Elena , Medar Cosmin , Manolescu Loredana Sabina Cornelia , Cătălin Rașcu Alexandru-Ștefan , Costache Maria Glencora , Radavoi George Daniel , Dobran Robert-Andrei , Jinga Viorel
Published: December 2023

(1) Background: Computed tomography (CT) imaging challenges in diagnosing renal cell carcinoma (RCC) include distinguishing malignant from benign tissues and determining the likely subtype. The goal is to show the algorithm’s ability to improve renal cell carcinoma identification and treatment, improving patient outcomes. (2) Methods: This study uses the European Deep-Health toolkit’s Convolutional Neural Network with ECVL, (European Computer Vision Library), and EDDL, (European Distributed Deep Learning Library). Image segmentation utilized U-net architecture and classification with resnet101. The model’s clinical efficiency was assessed utilizing kidney, tumor, Dice score, and renal cell carcinoma categorization quality. (3) Results: The raw dataset contains 457 healthy right kidneys, 456 healthy left kidneys, 76 pathological right kidneys, and 84 pathological left kidneys. Preparing raw data for analysis was crucial to algorithm implementation. Kidney segmentation performance was 0.84, and tumor segmentation mean Dice score was 0.675 for the suggested model. Renal cell carcinoma classification was 0.885 accurate. (4) Conclusion and key findings: The present study focused on analyzing data from both healthy patients and diseased renal patients, with a particular emphasis on data processing. The method achieved a kidney segmentation accuracy of 0.84 and mean Dice scores of 0.675 for tumor segmentation. The system performed well in classifying renal cell carcinoma, achieving an accuracy of 0.885, results which indicates that the technique has the potential to improve the diagnosis of kidney pathology.
Design and Study of Mechanical Cutting Mechanism for Submarine Cable Burial Machine
Authors: Yu Zhou , Jin Zhangyong , Wang Kaichuang , Zhang Chunyue , Chen Jiawang
Published: December 2023

This paper aims to explore the current state of research on submarine cable burial machines and proposes a novel mechanical burial machine design employing a chain-type structure based on a combination of theoretical considerations and practical requirements. Through theoretical analysis, simulation, and experimental studies, the cutting process of the mechanical burial machine is investigated in detail, with special attention given to the seabed conditions in the Northeast Asia region. Starting from the dynamic process of the blade–soil interaction and the working mechanism of the blade–soil system, an accurate and reliable model for the seabed rock–soil stress is established, along with a fast computation method. A destructive analysis of rock–soil mechanical cutting is performed, elucidating the influences of the cutting depth, cutting angle, and chain blade cutting speed on cutting resistance. This paper provides reference parameters for the design of chain-type trenching devices under different seabed conditions, and adjustments are made based on simulation experiments and actual soil trenching test results. These analyses contribute practical and reliable guidance for the design and optimization of submarine cable burial machines.
From Data to Insights: Machine Learning Empowers Prognostic Biomarker Prediction in Autism
Authors: Mehmetbeyoglu Ecmel , Duman Abdulkerim , Taheri Serpil , Ozkul Yusuf , Rassoulzadegan Minoo
Published: December 2023

Autism Spectrum Disorder (ASD) poses significant challenges to society and science due to its impact on communication, social interaction, and repetitive behavior patterns in affected children. The Autism and Developmental Disabilities Monitoring (ADDM) Network continuously monitors ASD prevalence and characteristics. In 2020, ASD prevalence was estimated at 1 in 36 children, with higher rates than previous estimates. This study focuses on ongoing ASD research conducted by Erciyes University. Serum samples from 45 ASD patients and 21 unrelated control participants were analyzed to assess the expression of 372 microRNAs (miRNAs). Six miRNAs (miR-19a-3p, miR-361-5p, miR-3613-3p, miR-150-5p, miR-126-3p, and miR-499a-5p) exhibited significant downregulation in all ASD patients compared to healthy controls. The current study endeavors to identify dependable diagnostic biomarkers for ASD, addressing the pressing need for non-invasive, accurate, and cost-effective diagnostic tools, as current methods are subjective and time-intensive. A pivotal discovery in this study is the potential diagnostic value of miR-126-3p, offering the promise of earlier and more accurate ASD diagnoses, potentially leading to improved intervention outcomes. Leveraging machine learning, such as the K-nearest neighbors (KNN) model, presents a promising avenue for precise ASD diagnosis using miRNA biomarkers.
Unmasking the Silent Threat: Periodontal Health’s Impact on COPD Severity and Hospitalization
Authors: Subbappa Anitha , Lokesh Komarla Sundararaja , Chaya Sindaghatta Krishnarao , Kaleem Ullah Mohammed , Siddaiah Jayaraj Biligere , Bhojraj Nandlal , Mahesh Padukudru Anand
Published: December 2023

Objective: This study investigated the relationship between chronic obstructive pulmonary disease (COPD) and periodontitis, focusing on how periodontal health impacts COPD airflow limitation, exacerbations, and hospitalization. Background: Periodontitis, a multifactorial inflammatory disease, is characterized by destruction of tooth-supporting structures, while COPD is a global pulmonary disorder with high mortality. Methods: A total of 199 COPD patients aged over 40 years underwent lung function tests (spirometry), 6 min walk test, and St George’s Respiratory Questionnaire-COPD (SGRQ-C) to assess lung health. Periodontal indices such as probing depth (PD), clinical attachment loss (CAL), and plaque index (PI) were assessed. Results: We found a significant negative correlation between periodontal disease severity and lung function (lower FEV1, FVC, and FEV1/FVC ratio) after adjusting for smoking. Likewise, periodontal parameters (PPD, PI, and CAL) exhibited negative correlations with lung function. These periodontal indices were independently associated with airflow limitation severity, exacerbations frequency, and prior-year hospitalization. Linear regression indicated that each unit increase in PPD, PI, and CAL corresponded to estimated increases in GOLD airflow limitation grading (0.288, 0.718, and 0.193, respectively) and number of exacerbations (0.115, 0.041, and 0.109, respectively). In logistic regression, PPD, PI, and CAL adjusted odds ratios (ORs) were estimated to increase by 1.29 (95%CI: 1.03–1.62), 3.04 (95%CI: 1.28–7.2), and 1.26 (95%CI: 1.06–1.49), respectively, for hospitalization in previous year. Conclusion: Periodontitis is associated with COPD airflow limitation, exacerbation, and hospitalization, with PI being the most clinically relevant periodontal factor. Dentists and physicians should monitor and increase awareness among COPD patients to maintain oral hygiene for prevention of periodontal diseases and mitigate its effect on COPD progression.
Evaluation and Management of Sudden Death Risk in Repaired Tetralogy of Fallot
Authors: Habib Eiad , Srivasthan Komandoor , El Masry Hicham
Published: December 2023

Although substantial progress has been made to prevent sudden cardiac death in repaired tetralogy of Fallot patients, ventricular arrhythmia and sudden death continue to be major causes of morbidity and mortality in these patients. Greater survival in contemporary cohorts has been attributed to enhanced surgical techniques, more effective management of heart failure, and increased efforts in risk stratification and management of ventricular arrhythmias. More recently, our understanding of predictive risk factors has evolved into personalized risk prediction tools that rely on comprehensive demographic, imaging, functional, and electrophysiological data. However, the universal applicability of these different scoring systems is limited due to differences between study cohorts, types of anatomic repair, imaging modalities, and disease complexity. Noninvasive risk stratification is critical to identify those who may derive benefit from catheter ablation or cardioverter defibrillator implantation for primary prevention. Ultimately, assessment and risk stratification by a multidisciplinary team is crucial to analyze the various complex factors for every individual patient and discuss further options with patients and their families.
Optimizing Utilization of Transport Capacities in the Cold Chain by Introducing Dynamic Allocation of Semi-Trailers
Authors: Stanković Ratko , Pereglin Tomislav , Erdelić Tomislav
Published: December 2023

Background: Road transport companies utilize transport capacities as fixed compositions of tractors and semi-trailers, while the possibility of exchanging semi-trailers is considered ad hoc, after some unforeseen circumstances emerge on the route. Such an approach is a limiting factor in achieving optimal utilization of transport capacities, and consequently affects profitability. We proposed a new concept of vehicle fleet management where semi-trailers would not be permanently assigned to the tractors, but could be dynamically reassigned, to utilize optimally the vehicle fleet, on considering the planned itinerary, the driver’s working hours, and traffic conditions. Methods: We set the key performance indicators and developed a prototype application based on the concept of dynamic semi-trailer allocation. We simulated the use of the prototype application on the historical data collected in the case study on one of the leading transport companies in the cold chain, and evaluated the benefits that may be achieved thereof. Results: Simulation showed that implementing the proposed concept enabled the reduction of the vehicle workdays spent on-the-route, the reduction of the number of vehicle compositions needed to handle the transport demand, and improved the quality of service. Conclusions: The proposed concept is beneficial for transport companies that operate large vehicle fleets on long-haul routes, with several transport orders per route. The prototype application may be the basis for developing a fully functional application that can be integrated into the fleet management system.
The Impact of Service Orientation and Airport Service Quality on Passenger Satisfaction and Image: Evidence from Indonesia
Authors: Usman Agus , Azis Yudi , Harsanto Budi , Azis Anton Mulyono
Published: December 2023

Background: Airport service quality and service orientation are important aspects of managing passenger satisfaction and airport image. The aim of this paper is to analyze the influence of service orientation and airport service quality on airport image through passenger satisfaction as an intervention variable. Methods: The survey was conducted on 356 passengers at the departure area and lounge. Samples were taken at five major airports in Indonesia, including Soekarno Hatta International Airport. To test the influence of exogenous variables on endogenous variables through intervening variables, a quantitative testing analysis test was carried out using the structural equation model partial least square (SEM-PLS). Result: The research results show that service orientation has a significant and positive effect on airport service quality, passenger satisfaction, and airport image. Moreover, service quality also has a positive effect on passenger satisfaction and the airport’s image. Empirically, passenger satisfaction has been proven to mediate the influence of service quality and service orientation on airport image. It has been proven that airport operators who focus on passengers through service orientation can increase passenger satisfaction and the airport’s image. Conclusions: Focusing on passengers’ needs while at the airport is an important aspect for airport operators who aim to manage their emotions, which encourages passengers to use paid services while in the waiting room. The use of this paid service will directly increase the airport’s aeronautical revenue. Future research needs to consider the influence of image on purchase intention and return to the airport.
Modified Induction Machine Equivalent Circuit Including Solid Shaft Eddy Currents
Authors: Tekgun Didem
Published: December 2023

The shaft eddy currents cause a significant saturation in two-pole induction machines (IMs) as they generate an opposing field and repulse the main flux, thus tightening the flux path. This results in inaccurate performance estimations with the magnetizing inductance measured in no-load conditions when the machine is loaded. This article presents a modified IM equivalent circuit considering the rotor back iron saturation effects caused by the solid shaft eddy currents using experimental measurements and recursive parameter estimation techniques. The classical equivalent circuit (CEC) parameters are determined with the standard test techniques followed by the parameter estimation of the newly introduced modified equivalent circuit (MEC) parameters. The proposed modified equivalent circuit is benchmarked with CEC and finite element analysis (FEA) simulations with and without considering eddy effects. The proposed MEC model and the FEA that consider eddy effects performed better than the other models and yielded a negligibly small error over a wide range of loading conditions. Compared to the FEA, the proposed MEC estimates the IM performance much faster, which makes it more appealing for IM performance estimations.
Transformer Text Classification Model for Arabic Dialects That Utilizes Inductive Transfer
Authors: Baniata Laith H. , Kang Sangwoo
Published: December 2023

In the realm of the five-category classification endeavor, there has been limited exploration of applied techniques for classifying Arabic text. These methods have primarily leaned on single-task learning, incorporating manually crafted features that lack robust sentence representations. Recently, the Transformer paradigm has emerged as a highly promising alternative. However, when these models are trained using single-task learning, they often face challenges in achieving outstanding performance and generating robust latent feature representations, especially when dealing with small datasets. This issue is particularly pronounced in the context of the Arabic dialect, which has a scarcity of available resources. Given these constraints, this study introduces an innovative approach to dissecting sentiment in Arabic text. This approach combines Inductive Transfer (INT) with the Transformer paradigm to augment the adaptability of the model and refine the representation of sentences. By employing self-attention SE-A and feed-forward sub-layers as a shared Transformer encoder for both the five-category and three-category Arabic text classification tasks, this proposed model adeptly discerns sentiment in Arabic dialect sentences. The empirical findings underscore the commendable performance of the proposed model, as demonstrated in assessments of the Hotel Arabic-Reviews Dataset, the Book Reviews Arabic Dataset, and the LARB dataset.
A Truthful Reverse Auction Mechanism for Federated Learning Utility Maximization Resource Allocation in Edge–Cloud Collaboration
Authors: Liu Linjie , Zhang Jixian , Wang Zhemin , Xu Jia
Published: December 2023

Federated learning is a promising technique in cloud computing and edge computing environments, and designing a reasonable resource allocation scheme for federated learning is particularly important. In this paper, we propose an auction mechanism for federated learning resource allocation in the edge–cloud collaborative environment, which can motivate data owners to participate in federated learning and effectively utilize the resources and computing power of edge servers, thereby reducing the pressure on cloud services. Specifically, we formulate the federated learning platform data value maximization problem as an integer programming model with multiple constraints, develop a resource allocation algorithm based on the monotone submodular value function, devise a payment algorithm based on critical price theory and demonstrate that the mechanism satisfies truthfulness and individual rationality.
Emergent Spatial–Temporal Patterns in a Ring of Locally Coupled Population Oscillators
Authors: Rusakov Alexey V. , Tikhonov Dmitry A. , Nurieva Nailya I. , Medvinsky Alexander B.
Published: December 2023

A closed chain of oscillators can be considered a model for ring-shaped ecosystems, such as atolls or the coastal zones of inland reservoirs. We use the logistic map, which is often referred to as an archetypical example of how complex dynamics can arise from very simple nonlinear equations, as a model for a separate oscillator in the chain. We present an original algorithm that allows us to find solutions to the spatiotemporal logistic equation quite efficiently or to state with certainty that there are no such solutions. Based on the Shannon formula, we propose formulas for estimating the spatial and temporal entropy, which allow us to classify our solutions as regular or irregular. We show that regular solutions can occur within the Malthus parameter region that corresponds to the irregular dynamics of a solitary logistic map.
All Roads Lead to Interferon-γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
Authors: Serio Bianca , Giudice Valentina , Selleri Carmine
Published: December 2023

Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T cell-mediated responses and can directly induce HSPC apoptosis and differentiation block. The use of omics technologies has amplified the amount of data at the single-cell level, and knowledge on AA, and new scenarios, have been opened on “old” point of view. In this review, we summarize the current state-of-art of the pathogenic role of IFNγ in AA from initial findings to novel evidence, such as the involvement of the HIF-1α pathway, and how this knowledge can be translated in clinical practice.
Efficacy of Transarterial Chemoembolization (TACE) for Early-Stage Hepatocellular Carcinoma
Authors: Lee Moonhyung , Shin Hyun Phil
Published: December 2023

Backgound and Objectives: The treatments of choice for patients with early-stage hepatocellular carcinoma (HCC) are surgical resection, local ablation therapy, and liver transplantation; however, transarterial chemoembolization (TACE) is commonly performed due to variations among patients and liver diseases. This study aimed to assess the efficacy of TACE in patients with early-stage HCC. Materials and Methods: A retrospective analysis was performed of all TACE procedures performed at Kyung Hee University Hospital at Gangdong over a 15-year period (July 2006 to November 2021). The study included a total of 97 eligible patients with early-stage HCC ≤ 5 cm initially treated with TACE. The mean participant age was 63.47 ± 11.02 years; 69 were men (71.1%). The number of Child–Pugh class A patients was the highest (74 patients [76.3%]), followed by Child–Pugh class B (19 patients [19.6%]) and Child–Pugh class C (4 patients [4.12%]). Results: A complete response was achieved in 84 (86.6%) patients after the first TACE procedure, with 1-, 2-, and 3-year survival rates of 91.8%, 87.3%, and 75.4%, respectively. In the multivariate analysis, the patients with a low initial alpha-fetoprotein (AFP) ≤ 20 ng/mL (p = 0.02) and a complete response after the first TACE (p = 0.03) were associated with favorable overall survival. Conclusions: TACE can be used to treat patients with early-stage HCC who are unsuitable for ablation or surgery. If patients are well selected, TACE may be an alternative treatment for patients with low AFP levels who respond well to the initial TACE procedure.
Immediate Effects of Sprinter-Pattern Exercise on the Lordotic Curve and Abdominal Muscle Activity in Individuals with Hyperlordosis
Authors: Lee Sangbong , Kim Hyunjoong , Jung Jihye , Lee Seungwon
Published: December 2023

Background and Objectives: Abdominal muscle exercises with limb movements are more effective for trunk stabilization than traditional exercises involving trunk flexion alone. This study examined the effects of abdominal exercises incorporating sprinter pattern and crunch exercises on changes in the lordotic curve and abdominal muscle activation in individuals with low back pain caused by hyperlordosis resulting from weak abdominal muscles. Materials and Methods: In this single-blind, randomized controlled trial, a total of 40 participants with hyperlordosis were recruited and randomly assigned to perform either sprinter-pattern abdominal exercises or crunch exercises. The participants assigned to each group performed three sets of ten abdominal exercises. The lumbar lordotic angle (LLA) and sacrohorizontal angle (SHA) were assessed prior to and following the intervention, whereas abdominal muscle activity was gauged throughout the intervention period. Changes in the LLA and SHA were measured by radiography. Abdominal muscle activity was measured using electromyography. Results: The LLA and SHA decreased significantly in both groups (p < 0.001), while the sprinter-pattern exercise group showed a statistically significant decrease compared to the crunch exercise group (p < 0.001). In the activity of the abdominal muscles, there was no significant difference in the rectus abdominis muscle between the two groups (p > 0.005). However, a significant difference between the external and internal oblique muscles was observed, and the activities of both muscles were significantly higher in the sprinter-pattern exercise group than in the crunch exercise group (p < 0.005). Conclusions: Abdominal exercise using a sprinter pattern may be effective in reducing lumbar lordosis by strengthening the abdominal muscles in patients with hyperlordosis.
Thrombolysis in Myocardial Infarction Frame Count for Coronary Blood Flow Evaluation during Interventional Diagnostic Procedures
Authors: Yamazaki Tatsuro , Saito Yuichi , Kitahara Hideki , Kobayashi Yoshio
Published: December 2023

Background and Objectives: An interventional diagnostic procedure (IDP), including intracoronary acetylcholine (ACh) provocation and coronary physiological testing, is recommended as an invasive diagnostic standard for patients suspected of ischemia with no obstructive coronary arteries (INOCA). Recent guidelines suggest Thrombolysis In Myocardial Infarction frame count (TFC) as an alternative to wire-based coronary physiological indices for diagnosing coronary microvascular dysfunction. We evaluated trajectories of TFC during IDP and the impact of ACh provocation on TFC. Materials and Methods: This was a single-center, retrospective study. Patients who underwent IDP to diagnose INOCA were included and divided into two groups according to the positive or negative ACh provocation test. Wire-based invasive physiological assessment was preceded by ACh provocation tests and intracoronary isosorbide dinitrate (ISDN). We evaluated TFC at three different time points during IDP; pre-ACh, post-ISDN, and post-hyperemia. Results: Of 104 patients, 58 (55.8%) had positive ACh provocation test. In the positive ACh group, resting mean transit time (Tmn) and baseline resistance index were significantly higher than in the negative ACh group. Post-ISDN TFC was significantly correlated with resting Tmn (r = 0.31, p = 0.002). Absolute TFC values were highest at pre-ACh, followed by post-ISDN and post-hyperemia in both groups. All between-time point differences in TFC were statistically significant in both groups, except for the change from pre-ACh to post-ISDN in the positive ACh group. Conclusions: In patients suspected of INOCA, TFC was modestly correlated with Tmn, a surrogate of coronary blood flow. The positive ACh provocation test influenced coronary blood flow assessment during IDP.
Optimizing Annealing Temperature Control for Enhanced Magnetic Properties in Fe-Si-B Amorphous Flake Powder Cores
Authors: Kim Hea-Ran , Lee Dongsup , Yang Sangsun , Kwon Young-Tae , Kim Jongryoul , Kim Yunseok , Jeong Jae-Won
Published: December 2023

In this study, we examined the optimal pre- and post-annealing conditions for soft magnetic composites (SMCs) using amorphous flake powders produced through ball milling of amorphous Fe-Si-B ribbons, leading to enhanced magnetic properties. The SMCs, which utilized flake powders created via melt spinning, displayed outstanding DC bias characteristics, as well as increased permeability, primarily due to high saturation magnetization and the flaky morphology of the powders. Pre-annealing was performed not only to remove residual stress formed during the melt spinning process but also to improve pulverizing efficiency, which ultimately affected the particle size of the flake powders. Core annealing was performed to reduce core losses and improve permeability by relieving the residual stress generated during the pressing process. As a result, pre-annealing and core annealing temperatures were identified as crucial factors influencing the magnetic properties of the SMCs. We meticulously analyzed the particle size, the morphology of the flake powder, and the magnetic properties of the SMCs in relation to the annealing temperatures. In conclusion, we demonstrated that flake powder SMCs achieved superior soft magnetic properties, including significantly reduced core loss and heightened permeability, through optimal pre- and core-annealing at 370 °C and 425 °C, respectively.
Improving Welding Penetration and Mechanical Properties via Activated-Flux Smearing by Tungsten Inert Gas Arc Welding
Authors: Yue Shiqi , Huang Yong , Yu Xiaoquan , Zhang Jia , Ni Yu , Fan Ding
Published: December 2023

For the welding process of thick-walled structural components in liquid rocket engines, the activated-flux TIG method can effectively address issues such as the formation of intermetallic phases in the weld seams, thereby enhancing mechanical performance. The present study investigates the activated-flux TIG welding technique on 10mm thick 1Cr21Ni5Ti duplex stainless steel plates. Various activated-flux, including -SiO2, TiO2, V2O5, NiO, MnO2, CaO, AlCl3, CaF2, B2O3 Cr2O3, and Al2O3, were examined to understand their impact on the weld-bead geometry. The aim was to determine the optimal activator ratio for the effective welding of 1Cr21Ni5Ti duplex stainless steel. The weld-shift experiment confirmed that the deep penetration observed in flux-assisted welding is attributed to Marangoni convection in the molten pool. Comprehensive evaluations and analyses were performed on the microstructure and mechanical properties of the normal welded joint and the A-TIG welded joint. Finally, the study delves into a discussion on the factors influencing changes in the weld penetration, microstructure, and mechanical properties of the weld.
AAV Immunotoxicity: Implications in Anti-HBV Gene Therapy
Authors: Jacobs Ridhwaanah , Dogbey Makafui Dennis , Mnyandu Njabulo , Neves Keila , Barth Stefan , Arbuthnot Patrick , Maepa Mohube Betty
Published: December 2023

Hepatitis B virus (HBV) has afflicted humankind for decades and there is still no treatment that can clear the infection. The development of recombinant adeno-associated virus (rAAV)-based gene therapy for HBV infection has become important in recent years and research has made exciting leaps. Initial studies, mainly using mouse models, showed that rAAVs are non-toxic and induce minimal immune responses. However, several later studies demonstrated rAAV toxicity, which is inextricably associated with immunogenicity. This is a major setback for the progression of rAAV-based therapies toward clinical application. Research aimed at understanding the mechanisms behind rAAV immunity and toxicity has contributed significantly to the inception of approaches to overcoming these challenges. The target tissue, the features of the vector, and the vector dose are some of the determinants of AAV toxicity, with the latter being associated with the most severe adverse events. This review discusses our current understanding of rAAV immunogenicity, toxicity, and approaches to overcoming these hurdles. How this information and current knowledge about HBV biology and immunity can be harnessed in the efforts to design safe and effective anti-HBV rAAVs is discussed.