bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh soft dan hard services terhadap akreditasi dan loyalitas pemustaka
Authors: Sungadi Sungadi
Published: June 2018

Introduction. As of January 2018 The Directorate of UII Library re-obtained the accreditation A from the National Library of Indonesia, and also become  the best unit of UII in 2017, it needs to have further evaluation.Data collection method. The survey was conducted at UII Library in July-October 2017, with sample of 252 students as respondents using purposive sampling. The hypothesis in this paper was there is influence between soft and hard services to user loyalty through acceptable accreditation intervening variables.Data analysis. The data was analysed by using multiple regression and path analysis in SPSS 16.0. Multiple regression was used to test direct influence between variables, while  path analysis was used   to determine the effect of exogenous variables on endogenous variables through intervening variable.Results and Discussions. The results showed that  the level of service quality and loyalty was high-very high (79.75-82.83%). The simultaneous influence of soft service (X1) and hard service (X2) on loyalty (Z) through accreditation (Y) increased  from 0.329 to 0.442 (0.442> 0.329). Simultaneously soft service (X1), hard service (X2) via accreditation (Y)-affected loyalty of library users (Z).Conclusions. In this research can be concluded that: Quality of service in UII Library Directorate in high condition s.d very high, while quality assurance level (accreditation) categorized high, and loyality pemustaka at very high level. The result of data analysis shows that the variable of soft service quality and hard there is direct influence to loyalty pemustaka. Meanwhile, the variable of soft and hard service through accreditation variable has an effect on the loyalty of the user. Future researchers can develop this research by involving all libraries within the UII as an object of study.
Big data analytic untuk pembuatan rekomendasi koleksi film personal menggunakan Mlib. Apache Spark
Authors: Wahyudi Indah Survyana
Published: June 2018

Introduction. The digital age is characterized by the explosion of digital information that creates problems in information retrieval. Search engines have a weakness in the keywords/queries that users can remember. Recommendations arise as solutions to provide personal information. Data Collection Method. In this paper, the researcher presented a recommendation engine model using dataset from movielends.org.Analysis Data. Alternating Least Square-Weight Regulation (ALS-WR) was used as a big data analytic algorithm in rating prediction and Cosine Similiarity as the second filter to bring items closer to the genre. Results and Discussions.The results of  Root Mean Squared Error (RMSE) from 100K datasets were 0.96 (validation) and 0.94 (test). The results RMSE from 1M dataset were 0.86 (validation) and 0.96 (test). The results  RMSE from 10M dataset were 0.81 (validation) and 0.81 (test). The result cosine similarity was 1 for 100% resemblance and it  decreased based on the similarity level. The user acceptance test was 28% user accepts the result of first recommendation, this value increased to 62% acceptance level of the user against the second recommendation. Conclusions. The final results show that 75% of respondents prefer the second recommendation  from two-stage filtering than just collaborative filtering.
PHYTOCHEMICAL ANALYSIS AND ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF INDIGOFERA TINCTORIA L.
Authors: Swaminathan Chandrasekaran
Published: June 2018

Objective: The present study was designed to evaluate the phytochemical composition and antibacterial and antioxidant potential of methanolic leaf and root extracts of Indigofera tinctoria L.Methods: Phytochemical analysis was done using standard methods. The methanolic leaf and root extracts of the plant were tested against Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, Enterobacter aerogenes, and Salmonella paratyphi B by cup-plate agar diffusion method. The free radical scavenging activities of the methanol extracts of leaves and roots were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.Results: Phytochemical screening revealed the presence of carbohydrates, reducing sugars, alkaloids, saponins, phenolic compounds, and flavonoids in methanolic leaf and root extracts. Methanolic leaf extracts of the plant exhibited antibacterial activity against a wide range of bacteria, but the root extracts failed to inhibit the tested bacterial pathogens. The antioxidant activity determination revealed that at 100 μg/ml, methanolic root extracts had the highest antioxidant activity (89.10%) on DPPH free radicals followed by methanolic leaf extracts (46.74%).Conclusion: The results of the present study conclude that the studied plant possesses broad-spectrum antibacterial and antioxidant properties and may act as a potent antioxidant for biological systems susceptible to free radical-mediated reactions.
ANALYSIS OF PROTEIN CONCENTRATE FROM KAHAI (CARYODENDRON ORINOCENSE KARST) SEEDS CULTIVATED IN AMAZONIA OF ECUADOR
Authors: J Greffa , E Vilcacundo , J Altuna , W Carrillo
Published: June 2018

Objective: The aim of this study was to obtain Kahai protein concentrate from Caryodendron orinocense Karst cultivated in the Amazonic region of Ecuador, to characterize its proteins using the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and native electrophoresis methods, and to determine its content of total polyphenols.Methods: Kahai seeds (C. orinocense Karst) were utilized to obtain Kahai protein concentrate at pH 3.0, pH 4.0, pH 5.0, and pH 6.0 using the isoelectric precipitation method. The proteins were characterized using the SDS-PAGE and native-PAGE electrophoresis methods. Total polyphenols were determined using the colorimetric assay method.Results: The best treatment to obtain Kahai protein concentrate was at pH 5.0 with a 21.91% yield using the cold extraction method. The best treatment was at pH 6.0 with a 11.07% yield using the heat extraction method. Kahai concentrates presented a complex profile of proteins with molecular weights between 14 and 97 kDa. It was possible to obtain at the same time polyphenols at pH 5.0 with a value of 1028.58 mg gallic acid equivalents/100 g protein of sample.Conclusion: This study suggests that Kahai protein concentrates possess a high content of proteins and polyphenols that can be used to elaborate functional foods.
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF LEVOFLOXACIN HEMIHYDRATE USING HYDROXYPROPYL METHYLCELLULOSE K4M TO TREAT HELICOBACTER PYLORI INFECTION
Authors: Baratam Srinivasa Rao , J Vijayaratna
Published: June 2018

Objective: The aim of the study was to develop a floating drug delivery system of levofloxacin (LVF) hemihydrate for sustained drug delivery to improve the extended retention in the stomach, oral bioavailability, and local site-specific action in the stomach. Methods: Preparation of LVF tablets using melt granulation method using hydroxypropyl methylcellulose (HPMC) K4M with sodium bicarbonate as gas generating agent. From LFTA1 to LFTA5, formulations were developed and evaluated for floating properties for swelling characteristics and in vitro drug release studies. In vitro dissolution was carried out using USP II paddle method using 0.1N HCI pH buffer at 50 rpm and samples were measured at 294 nm using ultraviolet-visible spectroscopy. Results: Obtained Fourier-transform infrared charts indicated that there is no positive evidence for the interaction between LVF and ingredients of the optimized formula. In vitro drug release was performed and drug release kinetics were evaluated using the linear regression method and were found to be followed the zero-order release by diffusion controlled release. Optimized formula was found to be LFTA4 with 20% of a polymer with 99.03% of drug release with 12 h of floating time and 32 s floating lag time. Conclusion: Matrix tablets (LFTA4) formulated employing 20% HPMC K4M are best suited to be used for gastroretentive dosage form of LVF.
BIOINFORMATIC STUDY OF AN ANTITUMOR PROTEIN, AZURIN
Authors: Valli S Abiraami , T Mythili
Published: June 2018

Objective: The main objective of this study is to analyze the structure and function of an antitumor protein, azurin, thereby giving validation to the protein structure and existing physicochemical properties in the anticancer protein which are responsible for the anticancer activity.Methods: Protein sequence analysis was done using Basic Local Alignment Search Tool (BLAST) with ten different randomly selected species of Pseudomonas obtained from GenBank. The physicochemical properties, prediction of secondary structure, identification of motifs and domains, three-dimensional (3-D) structure of the antitumor protein, validation through Ramachandran plot, multiple sequence alignment (MSA), and phylogenetic analysis were studied and functional property was confirmed through in silico docking.Results: The similarity search (BLAST-P analysis) for the primary sequence from GenBank carried out showed 86% similarity to the second sequence, azurin (Pseudomonas nitroreducens). The ProtParam, ExPASy tool server indicated the presence of essential physicochemical properties in azurin. Secondary structure prediction revealed random coil, extended strand, alpha helix, and beta turn. The study on domains indicated the presence of one domain in azurin responsible for the anticancer activity. The 3-D structural analysis revealed azurin as metalloprotein, of length-128, and polymer-1 with α-helices, β-sheets, and β-barrels. The validation carried out through Ramachandran plot showed the presence of two outliers (phi and psi). The biological relationship between the input sequences was studied through MSA and phylogenetic analysis. Further, azurin docked against the target protein (p53 tumor suppressor) showed the maximum binding affinity confirming its functional property of causing apoptosis.Conclusion: All the properties analyzed in the present study revealed that the azurin protein can act as a very good anticancer agent, and through the phylogenetic analysis, it was identified that Pseudomonas nitroreducens was closely related to the test organism Pseudomonas aeruginosa.
RESEARCH AND DEVELOPMENT IN WOUND MANAGEMENT PRODUCTS: A BRIEF REVIEW
Authors: Geetha V Surya , Gupta N Vishal , Dv Gowda , Pk Kulkarni
Published: June 2018

Wound can be defined as any process which leads to the disruption of the normal architecture of a tissue. They may be closed or open, for example, abrasions, lacerations, avulsions, ballistic and excised, or surgical wounds. Successful wound care includes advancing patient local and systemic conditions in conjunction with a perfect injury healing condition. Numerous wide assortments of dressing materials are accessible both for extreme and persistent non-healing wounds. A wide range of wound healing products have been produced to impact this injury condition to give a non-pathogen, ensured, and clammy region for healing to happen. A perfect injury dressing ought to limit loss of protein, electrolytes, and liquids from twisted and to diminish pain and contamination alongside wound healing. More current products are as of now being utilized to supplant or enlarge different substrates in the injury healing period. There is a sharp complexity to prior routine of wound administration, where the injury is permitted to dry, yet the present advancement was to move forward to the idea of wet injury recovering. This review of the present wounding periphery in wound recovery occurs at the most recent utilizations of silver and the employments of negative pressure wound gadgets, propelled dressings and skin substitutes, and biologic injury items including development of hydrogels and hyperbaric oxygen as an aid in wound mending. With the advancement of accessible dressings, the objective is to locate the most proper methodology or blend of modalities to optimize wound healing.
SUPPRESSION EFFECT OF MAHKOTA DEWA (PHALERIA MACROCARPA) LEAF EXTRACT IN CHITOSAN NANOPARTICLES ON THE SMALL INTESTINE OF DEXTRAN SULFATE SODIUM-INDUCED MICE: FOCUS ON MITOSIS AND HYPERPLASIA
Authors: Kusmardi Kusmardi , Tamzir Arif Ramadhan , Widiasari Santi , Estuningtyas Ari
Published: June 2018

Objective: The incidence of small intestine cancer (SIC) is rising despite available preventive measures. Kaempferol and quercetin are a potential chemopreventive agent for SIC, but in vivo findings are inconclusive. We aim to study the effects of kaempferol and quercetin on colitis-associated small intestine carcinogenesis in mice.Methods: Suppression effect was tested using mice divided into 6 groups of treatment, i.e.; normal (N) group, negative control (NC), leaf extract (medium dose [MD]) dose 12.5 and 25 mg/kg body weight (BW), leaf extract chitosan and nanoparticle of mahkota dewa (NPMD) dose 6.25 and 12.5 mg/kg BW. Dextran sulfate sodium induction of 1% w/v was administered through drinking water for 6 weeks of treatment. The suppression effect was observed histopathologically by counting the mitotic cells and hyperplasia cells of the crypt of small intestine with hematoxylin-eosin staining.Results: Mitosis cells mean of NC group was not significant difference either with MD 12.5 (p=0.394) or MD 6.5 (p=0.310). However, mitosis cell mean appears to be lower in the NPMD 12.5 (p=0.09) and NPMD 6.25 (p=0.05) groups than the NC group. There was a significant difference among the mean of hyperplasia NC group and MD and also NPMD group. Significant difference also can be showed between MD 12.5 and MD 25 (p=0.026), and between NPMD 6.25 and NPMD 12.5 (p=0.002), and between MD 12.5 and NPMD 12.5 (p=0.002).Conclusion: Our results demonstrate suppression of hyperplasia small intestine by either nanoparticle or extract of Phaleria macrocarpa extracts. The suppression of mitosis was showed by administration of nanoparticle.
CHEMICAL STRUCTURE OPTIMIZATION OF LUPEOL AS ER-Α AND HER2 INHIBITOR
Authors: Pratama Mohammad Rizki Fadhil , S Sutomo
Published: June 2018

Objectives: Lupeol, a triterpenoid isolated from Kasturi (Mangifera casturi) fruit has been known for having several pharmacological activities, including anticancer properties. Lupeol showed antiproliferative activity toward many cancer cells line including breast cancer. Lupeol showed promising potency as both ER-α and HER2 inhibitors, although still lower than known ER-α and HER2 Inhibitors. Chemical structure optimization of lupeol was predicted could increase the affinity of lupeol derivatives against ER-α and HER2. This study aims to determine lupeol derivative with the highest affinity against ER-α and HER2.Methods: All ligands were sketched and optimized using Gaussian 03W with Hartree–Fock method basis set 3-21G. Molecular docking was performed using Autodock 4.2.6 on several modified chemical structure of lupeol against active site of ER-α and HER2. The main parameter used was the free energy of binding and inhibition constants as affinity marker.Results: The docking results show that lupeol derivative with an amine group (Lupeol-2) and ethyl group (Lupeol-4) at position C3 provide the highest affinity with the free energy of binding and dissociation constant −12.24 kcal/mol and 1.07 nM for ER-α also −9.63 kcal/mol and 86.94 nM for HER2, respectively. Interestingly, although lupeol derivatives showed higher affinity toward ER-α, their amino acid residues were closer to the interaction on HER2.Conclusion: These results predict that lupeol have greater potential to be developed as a HER2 inhibitor. Further, derivate lupeol-4 should be potential to be developed as HER2-positive breast cancer therapy.
MALAYSIAN MEDICINAL PLANTS’ POTENTIAL FOR BREAST CANCER THERAPY
Authors: Mainasara Muhammad Murtala , Abu Bakar Mohd Fadzelly , C Linatoc Alona
Published: June 2018

Objective: This review focused on Malaysian medicinal plants that have been evaluated and pose potentials to treat breast cancer.Methods: Google Scholar, Web of Science, PubMed, Scopus, Biomed, ResearchGate, academia.edu, IEEE Xplore, ScienceDirect, and Ingenta databases were searched for this review and studies reported between January 1st, 2010 and June 30th, 2016.Results: A total of 105 plants species representing 54 different families and 79 genera were reviewed. 97% of the plants were tested using MCF-7 and MDA-231 breast cancer cell lines and exhibited most significant in vitro anticancer activity, and 3% were tested using another type of breast cancer cell lines. Most of the bioactive compounds of the medicinal plants that exhibited good activity (IC50 values <120 μg/mL) are a group of phenols, alkaloids, flavonoids, terpenoids, and saponins. Induction of apoptosis was found to be the significant cell death pathway.Conclusion: This article reviews the available literature concerning research on anti-breast cancer plants. Furthermore, identification and characterization of active components and toxicology evaluation also need to be studied in details and also point out their clinical trials.
SAFETY AND EFFICACY OF THREE TREATMENT REGIMENS OF R-CHOP, E-CHOP, AND R-CHOEP IN NON-HODGKIN LYMPHOMA CANCER PATIENTS
Authors: Ahmad Ayaz , Daud Ali Mohammad , Almahmoud Sana
Published: June 2018

Objective: This study was designed to investigate safety, efficacy of different regimens such as R-CHOP, E-CHOP, and R-CHOEP used in the treatment of in non-Hodgkin lymphoma (NHL) cancer patients.Methods: Available and required data of 64 NHL cancer patients were collected. Data were related to demography of patients, name of the drug, dose, route, frequency, duration of therapy, and investigational reports.Results: This study showed some variation and similarities in different regimens. Arm-A (R-CHOP) and Arm-B (E-CHOP) showed similar result for Eastern Cooperative Oncology Group (ECOG) score 2 but showed different result of ECOG score 0 and 1. High percentage of patient was taken in Arm-A and Arm-B as compared to Arm-C (R-CHOEP) for ECOG score 2. Surprisingly, it was found that very few percentages of patients showing progressive disease during R-CHOEP as compared to R-CHOP, E-CHOP therapy.Conclusion: From this study, it was concluded that Arm-C (R-CHOEP) showed better result in comparison of Arm-A (R-CHOP) and Arm-B (E-CHOP). As far as toxicity is concern, early detection and personalized management may improve clinical outcome and tolerance.
MEDICINAL PLANTS AS POTENTIAL SOURCE OF ANTIOXIDANT AGENTS: A REVIEW
Authors: Ayoub Zeenat , Mehta Archana
Published: June 2018

All over the world, the recent scientific studies revealed the medicinal properties of plants, which have been examined, because of their effective pharmacological activities, economic viability, and their low toxicity. Reactive oxygen species (ROS) enhancement by endogenous and exogenous stimuli can modify redox circumstances of normal cells. To balance ROS-mediated cellular damage, endogenous antioxidants’ protection system subsists; however, when oxidation surpasses the control mechanisms, oxidative stress increases. Detrimental alterations induced in a variety of biomolecules such as proteins, lipids, and DNA which causes chronic escalation of oxidative stresses, which ultimately causes tissue damage and results in numerous diseases. Antioxidants reduce the effects of ROS and help us in the prevention of such diseases. Antioxidants can either be natural or synthetic. Natural antioxidants can be obtained through diet in the form of fruits, spices, vegetables, etc. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole also diminish oxidation, but they have been proved to be dangerous to humankind; therefore, investigation for non-toxic antioxidants has increased in the recent years.
ETHNOPHARMACOLOGICAL REVIEW OF NATURAL PRODUCTS IN CANCER PREVENTION AND THERAPY
Authors: Ayoub Zeenat , Mehta Archana , Mishra Siddhartha Kumar
Published: June 2018

The World Health Organization reports that approximately 80% population from developing countries are facing complications from synthetic drugs used in maintaining their primary health-care needs. The chemotherapeutic strategies are very striking and have earned serious concern as potential means of controlling the incidence of this dreadful disease. However, the major problem in cancer is the long lasting toxicity of the well reputable chemical drugs. Since ancient times, medicinal plants have attracted enormous attention, to fight against various diseases with their broad-spectrum biological and therapeutic properties. Although plants, phytochemicals and their analogues have been confirmed to be safe and effective, having strong anticancer properties. A number of pharmaceutical agents with diverse chemical structures of natural origin from plants have been discovered as anticancer agents such as vincristine, vinblastine, podophyllotoxin, camptothecin, taxol, resveratrol, withaferin A, quercetin, and curcumin. Further modifications of these phytochemicals led to the development of numerous outstanding molecules such as drugs like topotecan, irinotecan, taxotere, etoposide, and teniposide. In this in-depth review, we meticulously investigated the selected medicinal plants for their anticancer properties. In particular, novel compounds from plants have beneficial effects on human health. Our observations suggest the preventive and therapeutic use of phytochemicals in managing various human malignancies.
SELECTION OF BUFFALO MILK LACTIC ACID BACTERIA WITH PROBIOTIC POTENTIAL
Authors: Melia Sri , Yuherman Yuherman , Jaswandi Jaswandi , Purwati Endang
Published: June 2018

Objective: The aim of this research was to isolate and identify lactic acid bacteria using 16S rRNA and evaluates their potential as probiotics.Methods: The probiotic properties measured were resistance to low pH and to 0.3% and 0.5% bile salts, antimicrobial activity against pathogenic bacteria (Escherichia coli O157:H7 and Staphylococcus aureus ATCC 25923), antibiotic resistance, and hydrophobicity.Results: The lactic acid bacteria with optimal probiotic properties were isolated from buffalo milk and identified from a sample from Agam district (BMA 3.3) which was classified using BLAST analysis as a strain of Lactobacillus fermentum (L23). Conclusion: Buffalo milk from this part of West Sumatera contains a strain of L. fermentum with has good probiotic properties.
LITHISTID SPONGES DERIVED COMPOUNDS AND THEIR IMPORTANCE IN BIOLOGICAL RESEARCH - A REVIEW
Authors: M Abirla , Devi P Brindha
Published: June 2018

Lithistid sponges have an important source of complex natural compounds with biological activities. The lithistid sponges are of interest to biomedical science because of the great variety of pharmaceutically relevant biological activities of their chemical extracts and are considered as economically important. The compounds identified in these sponges have therapeutic potential and have been frequently hypothesized to contain compounds of bacterial origin. The peptides identified from these lithistid sponges are found to be the sources of antifungal activity. The active agents of these sponges also have cytotoxic and immunosuppressive activities. Many of the cyclic peptides of lithistid represent the anti-HIV activity. The different structure and biological activities of the compounds derived from these sponges have more chemical aspects too.
A REVIEW ON DNA NANOBOTS – A NEW TECHNIQUE FOR CANCER TREATMENT
Authors: Umai R Devasena , Devi P Brindha , R Thiruchelvi
Published: June 2018

Cancer is one of the deadliest diseases of this century. Tedious and painful radiation therapy and chemotherapy are administered using many drugs including antitumor antibiotics, which cause a lot of side effects. As an alternate, DNA nanorobots serve as a potential cancer treatment technique which is very much safer than other therapies and acts specifically as well. DNA nanobots are said to set a new milestone in the development of medical studies. The primary objective of this bot is to target and eliminate cancer cells from the human body. These bots are made of a single strand of DNA folded into the desired shape. The bots will have two states - an “off” position, where the clamshells are closed tightly to bypass healthy cells without any damage and an “on” position, where the clamshell opens up to expose cancerous cells to the drug so that the drug can do its job to eliminate the cancer cell. This novel idea will be actively used within the public when it passes its first human trial. In this review, we focus on eliminating cancer cells. Since the bot can be programmed and is capable enough to carry a payload, it can also be used to cure any other diseases as a secondary target. Creation of nanobots has been under progress already and may come within the public after an estimated time of 5 years.
CHANGES IN THE TOTAL POLYPHENOLIC CONTENT AND ANTIOXIDANT ACTIVITY OF FERMENTED MORINDA CITRIFOLIA L.
Authors: Chaiyasut Chaiyavat , Sivamaruthi Bhagavathi Sundaram , Kesika Periyanaina , Sirilun Sasithorn , Chaiyasut Khontaros , Yoosupap Rattikan , Peerajan Sartjin
Published: June 2018

Objective: The fermented plant beverages (FPBs) are considered as functional food. A detailed scientific investigation is required to develop functionally potential FPBs. The present study aimed to investigate the changes in total phenolic content and antioxidant properties of Lactobacillus paracasei HII01-mediated fermented Morinda citrifolia L. (noni) juice.Methods: The fermentation media consist of 3:10:1 ratio of noni, water, and carbon source (either cane sugar or honey) along with 10% of inoculum (L. paracasei). The control samples were prepared without inoculum or substrate. The variations in pH, acidity, total phenolic content, and the antioxidant capacity of the samples were kinetically measured by standard methods.Results: The pH and total acidity of the samples were progressively reduced and improved when the duration of fermentation was prolonged, respectively. After 15 days of fermentation, F1 (1.198 mg GAE/ml sample) and F3 (1.265 mg GAE/ml sample) exhibited high total phenolic compound compared to other samples. Likewise, sample F3 displayed maximum antioxidant capacity. The samples with cane sugar exhibited high phenolic content, free radical scavenging activity, and chelating power than samples with honey.Conclusion: About 15 days of fermentation in sufficient to obtain the high quality (rich in phenolic compounds and antioxidant capacity) fermented M. citrifolia juice using L. paracasei, and cane sugar as starter, and carbon source, respectively
ANTI-MYCOBACTERIUM TUBERCULOSIS STRAIN H37RV AND IRON CHELATION ACTIVITY OF SAPPAN WOOD EXTRACT (CAESALPINIA SAPPAN L.) IN VITRO
Authors: Safitri Ratu , Indrawati Ida , Syamsunarno Mas Rizky A A , Ghozali Mohammad , A Gani Basri , Panigoro Ramdan
Published: June 2018

Objective: The objective of this study is to determine anti-Mycobacterium tuberculosis (MTB) strain H37Rv and iron chelation activities of sappan wood extract (SWE).Methods: The evaluation of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) by proportion methods. Whereas the iron chelate in Lowenstein–Jensen (LJ) medium as the indicator of Mycobacterium growth and SWE effect.Results: The SWE has bacteriocidal to MTB of 10−3 and 10−5 dilutions in of all concentrations (250, 500, 750, 1000, 2000, 4000, 8000, and 16000 part per millions [ppm]) also bacteriostatic in concentration 50 and 100 ppm.Conclusion: The SWE at 100 ppm could inhibit 87% of the MTB in 10−3 and 10−5 dilutions, respectively, also to reduce to growth the colony of MTB, and has chelating effects of iron expression of LJ medium and MTB.
MOLECULAR DOCKING STUDIES OF SNAKE VENOM SERINE PROTEASE OF SHARP-NOSED PIT VIPER WITH HESPERETIN
Authors: Panda Subhamay , Ehsan Iman
Published: June 2018

Objective: The management of snake bite envenomation is a global challenge affecting millions of people. Immunotherapy is still regarded as the treatment of choice; however, their subsequent adverse effects restrict their potential use for therapy against snake venom poisoning. In recent years, more attention has been given to the exploration of indigenous medicinal plants for their outstanding benefits for the treatment of several diseases and disorders, including snake venom poisoning. Hesperetin is a naturally occurring compound derived from a flavanone glycoside, hesperidin and is obtained from various citrus fruits. It is known to possess significant inhibitory activity against snake venom serine proteases. The aim of our present study was to investigate the significant inhibitory action of hesperetin on thrombin-like serine protease from sharp-nosed pit viper (Deinagkistrodon acutus) snake venom.Methods: We have employed molecular docking analysis by implementing the state-of-the-art docking program to validate the hypothesis of the prospective inhibitory properties of hesperetin on thrombin-like serine proteases of snake venom. AutoDock 4.2, InterProSurf, MGLTools, and MTiAutoDock were utilized for the molecular docking analysis of thrombin-like serine protease obtained from the snake venom of sharp-nosed pit viper with the natural compound hesperetin.Results: The results generated from in silico based approach reveals the significant inhibitory role of hesperetin against thrombin-like snake venom proteases, which might lead to the drug designing of the inhibitors of snake venom serine proteases.Conclusion: The implementation of molecular docking analysis by the employment of state-of-the-art docking program supports the potential of inhibitory activity of naturally obtained hesperetin compound on thrombin-like serine proteases of snake venom. The generated in silico results suggests that the novel structure hesperetin - flavanone might act as a potent inhibitor of thrombin-like snake venom proteases, and unlocks the possibilities for designing drugs of the inhibitors of snake venom serine proteases. Moreover, the investigation of the novel compound obtained from natural sources for their inhibitory activity against snake venom serine proteases would lead to the discovery of newer inhibitory compound from a highly uninvestigated research arena.
EVALUATION OF “LEUCAS LANATA” AND ASSESSMENT OF ITS HEPATOPROTECTIVE EFFECTS ON ANTITUBERCULAR DRUG-INDUCED HEPATIC DAMAGE
Authors: Verma Pritt , Srivastava Sajal , Rao Ch. V.
Published: June 2018

Objective: The objective of this study was to investigate the hepatoprotective activity of ethanolic whole plant extract of Leucas lanata (family - Lamiaceae) against rifampicin+isoniazid (RIF+INH) induced hepatic damage in rats.Methods: Wistar rats of either sex were divided into five groups of six animals each and given orally the following treatment for 28 days. The normal control was given 1% CMC 1 ml/kg body weight (b.w.), RIF+INH antitubercular drug (ATT) at a dose of 50 mg/kg b.w., p.o. was given a toxic dose for inducing hepatotoxicity. Silymarin (100 mg/kg, p.o) was given as reference standard. Two different doses of Lucas lanata extract of 200 and 400 mg/kg, p.o were tested for hepatoprotective activity. At the end of the treatment, blood was collected from direct cardiac puncture and analyzed for numerous bodily fluid parameter such as alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphate (ALP), total protein (TP), and total bilirubin (TB) and oxidative stress parameter lipid peroxidation (LPO), superoxide dismutase (SOD), catalase, glutathione (GSH), malondialdehyde and also evaluated the hydroxyproline content, tumor necrosis factor alpha, and interleukin-1 beta in all groups. Livers were isolated for its essential estimation followed by histopathological studies.Results: Hepatic serum markers (ALT, AST, ALP, albumins, TP, and TB) were significant (p<0.01–p<0.001) protective effect was obtained against ATT-induced liver damage, and ATT treatment significantly decreased LPO, SOD, and GSH (p<0.001) levels compared with control Group I and given a Leucas lanata extract (LLE) (p<0.01–p<0.001), the oxidative stress markers were markedly reversed. Histopathology of liver tissue showed that LLE attenuated the hepatocellular necrosis, regeneration, and repair of cells toward normal. LLE which was standardized using high-performance thin-layer chromatography revealed the presence of some critical phenolic (gallic acid and quercetin) compound.Conclusion: The results of this study powerfully indicate the protecting result of LLE against liver injury which can be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use.
ENZYME-ENHANCED EXTRACTION OF CAMPTOTHECIN AND ITS ANTICANCER ACTIVITY ON BREAST CANCER CELL LINE
Authors: Natarajan Sujatha , Alagar Yadav Sangilimuthu
Published: June 2018

Objective: Camptothecin (CPT) is an alkaloid produced by endophytic fungi, and it acts against colon, uterine, and lung cancers as drug. Macerating enzyme cellulase is used to increase the extraction yield of CPT. The cytotoxicity and anticancer activity of CPT are being studied to aid in discovering its beneficial properties and its use as a lead compound in pharmacological industries.Methods: In this work, the extraction of CPT from the endophytic fungi is enhanced using the crude enzyme cellulase obtained from Aspergillus niger. CPT was extracted from A. niger by two ways such as using macerating enzyme cellulase (CWME) and without macerating enzyme (CWOME). High-performance liquid chromatography (HPLC) was carried out to characterize the extracted CPT against standard CPT. The yields of CPT extracted both ways were compared. Cytotoxicity of the extracted CPTs was studied against Vero cells. The anticancer activity of CPT was tested against the breast cancer cell line (MCF7).Results: The extracted compound was confirmed to be CPT using HPLC. The yield of CPT extracted with enzyme was more than that extracted without enzyme. The extracted CPT was found to be safe up to 1000 μg/ml against Vero cells. The IC50 value of the CWME was found to be 62.5 μg/ml compared to the CWOME (IC50 125 μg/ml) against the MCF7 cell line, thus inferring that the anticancer activity of CWME was higher than that of CWOME.Conclusion: Thus, it can be concluded that cellulase helps to increase the extraction yield of CPT from A. niger. CPT is safe against normal cell line and exhibits anticancer properties against MCF7.
Increasing Residency Research Output While Cultivating Community Research Collaborations
Authors: Weaver Sally P.
Published: June 2018

Background and Objectives: Having a research curriculum in addition to hosting a resident research day stimulates research activity in residency programs. Research collaborations outside an individual residency program may also promote research in residency. This paper describes a community-wide health research forum that engages faculty and residents in research while bringing together potential research collaborators from the community.
Methods: A yearly research forum has been held at a large community-based family medicine residency program for the past 10 years. This forum invites both residency faculty and residents to present scholarly works, and also invites researchers from the community to present health-related research. Presenters outside the residency come from hospital systems, the local university, other residency programs, and community private physicians.
Results: Peer-reviewed research publications have increased greatly since the advent of the research forum in 2006, with six publications from 1997-2006 and 26 from 2007-2016. Greater increases in numbers of peer reviewed presentations were also seen. Collaborative research has occurred between residency faculty and multiple departments at the local university including the business school, social work, public health, physiology, and statistics. There are now 28 collaborative projects completed or in progress.
Conclusions: Development and implementation of a regional health research event has been a success in increasing faculty and resident research productivity. The even greater success however, is the progress made in advancing research collaborations between the local university and the residency program.
Perspectives on Procedure Importance:
Authors: Ludden-Schlatter Alicia , Wells Jack , Kruse Robin L.
Published: June 2018

Background and Objectives: Procedural training is integral to family medicine residencies. Although accreditation bodies require that family medicine residency programs train residents in procedures relevant to their practices, there are no standards defining the scope of family medicine. We compared the perceived importance of 31 procedures by faculty, residents, and recent graduates of one institution.
Methods: An online survey was sent to current residents and faculty of a large academic family medicine residency, as well as community practitioners who had graduated from that residency within the past 5 years. The survey asked participants to rate how important 31 procedures are for family medicine practices.
Results: The overall response rate was 37%. Most respondents provided outpatient care, and few provided or intended to provide obstetric care. Dermatologic and musculoskeletal procedures were rated as having high importance by all groups, whereas obstetric and inpatient procedures received lower ratings. Residents ascribed higher importance than faculty or recent graduates for nearly all procedures.
Conclusions: Most residents, faculty, and community practitioners provided outpatient care and rated dermatologic and musculoskeletal procedures as important. Inpatient and obstetric care are less common career paths, and related procedures were rated as less important. Resident physicians ascribed greater importance than community practitioners for many procedures, which may be due misperceptions of their future practice needs or imposed requirements for graduation.
Educação inclusiva: uma garantia consagrada pelo estatuto da pessoa com deficiência
Authors: Almeida Marta Cristina Nunes , Reis Rafael Santos , Santos Thainá Santos
Published: June 2018

A educação inclusiva é um direito fundamental com amparo na Constituição Brasileira de 1988 e em Convenções Internacionais. Com a entrada em vigência do Estatuto da Pessoa com Deficiência, o indivíduo que tem impedimento de longo prazo de natureza física, mental, intelectual ou sensorial passou a gozar de capacidade jurídica, tendo suas garantias previstas de forma expressa. Nessa senda, a lei 13.146, de 06 de julho de 2015, representa uma homenagem ao Princípio da Dignidade Humana e determina que o acesso à educação aconteça de forma plena e participativa. A defesa de tal garantia deve ser observada por instituições de ensino públicas e privadas, sob pena do cometimento de crime punível comreclusão em caso de desobediência, em consonância com entendimento do Supremo Tribunal Federal. É importante que o disposto na lei supracitada seja colocado em prática, para que seja possível a formação de uma sociedade justa e igualitária.
Vertical facial disproportions in children with Class III malocclusion
Authors: Stojanovic Zdenka , Milic Jasmina , Pavlic Verica
Published: June 2018

Introduction/Objective. Class III malocclusion is a sagittal intermaxillary disproportion with dominant presence of mandible. Apart from primary sagittal, anomalies in vertical face dimension can also be present. The aim of this study is to evaluate vertical facial disproportions in the skeletal Class III malocclusion in stage of mixed dentition, in order to better plan its early therapy. Methods. In total 100 children were randomly selected and divided according to cephalometric analyzes in the two equal groups: Group 1 (experimental group) ? skeletal Class III malocclusion (n = 50) and Group 2 (control group) ? skeletal Class I (n = 50). The groups were further divided into three subgroups according to the age and gender of the children. Vertical craniofacial proportions were measured by anterior (upper, lower and total) and posterior facial height and their proportion. The values were statistically analyzed (p ? 0.05). Results. Upper anterior, lower anterior, total anterior and posterior facial height, proportion between lower and total anterior facial height, and proportion of posterior to total anterior facial height did not have a significant difference among children with Class I and Class III malocclusions. Upper anterior facial height proportional to total anterior facial height was statistically significant greater in experimental group when compared to control. Significant gender dimorphism was noted among the same subgroups. Conclusion. Vertical craniofacial proportions in children with Class III malocclusion in stage of mixed dentition was not significantly changed. This finding leaves room for the successful application of early, individually planned orthodontic therapy.
Modelos de internacionalización de los cantantes guayaquileños
Authors: Campoverde Aguirre Ronald
Published: June 2018

El artículo inicia con una descripción general de la globalización musical y la importancia de esta industria para el país. La metodología de investigación seguida fue cualitativa tipo exploratoria. Como herramienta de recolección de datos se utilizó la entrevista semi-estructurada, y la muestra fue escogida de varios artistas internacionalizados o con proyección de internacionalización de diferentes géneros. Se determinaron sus estrategias, proyecciones, motivaciones, factores determinantes y limitaciones, respondiendo a las preguntas de investigación planteadas en este artículo. La investigación busca determinar el modelo de internacionalización utilizado por los cantantes guayaquileños en el contexto actual. Entre los hallazgos más importantes es que modelo de internacionalización varía de acuerdo al género y al capital de inversión disponible, fluctuando entre el modelo evolutivo de la escuela de Uppsala, el modelo trampolín de Pla-Barber y el modelo Born Global de Sigala & Mirabal. El artículo invita también a explorar el modelo de internacionalización ideal para la industria de la música ecuatoriana.
Las recaudaciones tributarias y el crecimiento económico. Un análisis a través del pib de Ecuador
Authors: Segura Ronquillo Shirley Carolina , Segura Ronquillo Erika Alexandra
Published: June 2018

En este artículo se presenta un análisis teórico y estadístico de los resultados económicos del Producto Interno Bruto y las recaudaciones del Impuesto a la renta de Ecuador que muestran la relación teórica y empírica de estas variables para conocer si la recaudación tributaria del impuesto a la renta fue consecuente con el crecimiento económico del país. Para esto se tomaron datos de corte longitudinal de los resultados anuales de las variables el Producto Interno Bruto y el Impuesto a la renta de Ecuador entre los años 2008 y 2016 para ser analizados bajo un enfoque cuantitativo y deductivo aplicando un análisis de crecimiento porcentual y de regresión para establecer el nivel de incidencia que existe entre la variable independiente, el Producto Interno Bruto (PIB), y la variable dependiente, el Impuesto a la renta. Los resultados determinan que las recaudaciones fueron consecuentes con el crecimiento de la producción nacional dado que las variables mostraron una alta relación estadística del 96,20%, explicándose en un 93% el comportamiento de las recaudaciones del impuesto a la renta en relación al comportamiento del PIB.
Análisis de la teoría de juego en el proceso de dirección y administración estratégica
Authors: Rojas Davila Ruth Sabrina , Torres Briones Carlos Luis
Published: June 2018

La teoría de juegos se emplea cada vez más en economía y administración, porque nos ayuda a entender y pronosticar la realidad en ciertas situaciones en donde las decisiones se vuelven un tema complicado de ser escogido. Sus aplicaciones en la administración se concentran en tres áreas: la estrategia, la estructura y el comportamiento organizacional, en cambio en lo académico sirve para plantear las hipótesis y probar su coherencia interna. La literatura casi no reporta casos de su uso por los gerentes prácticos, realmente es poco usual que esto se ponga en práctica. Esto ocurre porque para los administradores prácticos resulta difícil plantear un modelo a partir de una situación real. El presente ensayo trata de subsanar esta carencia y proponer los principios de la creación de los modelos de juegos.
Guadalajara, refugio de migrantes centroamericanos / Guadalajara, refuge for Central American migrants
Authors: Arreola Díaz Hilda Verónica , Hernández González Adriana , Corona Flores Cristina
Published: June 2018

El artículo plasma de manera sencilla la situación de los migrantes centroamericanos en su odisea para tratar de alcanzar el sueño americano, encontrándose con la posibilidad de cambiar sus planes para residir temporal o definitivamente en la ciudad de Guadalajara Jalisco.
PENGARUH PELANGGARAN PERATURAN PERBANKAN TERHADAP KINERJA KEUANGAN BANK DI INDONESIA
Authors: Nurdin Yasmi , Shahib Habib Muhammad , Gafur Muhammad
Published: June 2018

Penelitian ini bertujuan untuk menguji secara empiris pengaruh pelanggaran peraturan perbankan terhadap kinerja keuangan bank di Indonesia. Penelitian ini menggunakan data sekunder yang diperoleh dari BI dan OJK, serta laporan keuangan bank yang terkait bank pelanggar peraturan perbankan di Indonesia dengan rentang tahun 2010-2013. Berdasarkan hasil penelitian dengan menggunakan pendekatan partially least squere. Ditemukan fakta empiris bahwa pelanggaran peraturan perbankan tidak berpengaruh secara signifikan terhadap kinerja keuangan perbankan, sehingga perlu dilakukan kajian lebih jauh atas efektifitas peraturan keuangan yang mengikat bank-bank di Indonesia dari segi teori dan konteks sosial ekonomi Indonesia. Namun demikian, penelitian ini menemukan fakta, ukuran bank pelanggar peraturan keuangan (SIZE) memiliki pengaruh positif dan signifikan secara langsung terhadap abnormalitas ROA dan ROE yang sering menjadi proksi dalam mengukur masalah pelanggaran peraturan keuangan, sehingga dapat dikaji lebih jauh sebagai salah satu tanda terjadinya pelanggaran peraturan keuangan di perbankan. Akhirnya, penelitian ini diharapkan dapat memberi masukan kepada pengembangan literatur akuntansi khususnya yang terkait dengan konteks perbankan dan memberikan pertimbangan kepada pihak berwenang atas  kebijakan dan pengontrolan bisnis melalui pengujian keefektifan peraturan perbankanyang hingga kini berlaku di Indonesia.
Kampung rendang
Authors: Nurhuda Lilla , Hasan Helmi , Eriyanti Fitri
Published: June 2018

The purpose of this research is to reveal the form of community support capacity, explain the constraints faced, and the efforts undertaken by the community in maintaining theicon as a village rendang. This research uses etnometodology method by using interview technique, observation and documentation. The results of this study indicate that the form of carrying capacity undertaken by the entrepreneurs are: maintaining the material and quality, maintaining quality improvement of workers and institutional support (cooperative and marketing). Constraints faced are: low technology, lack of human resources (quality of workers), marketing. The efforts undertaken in the community in maintaining the icon as a village rendang namely: utilization of social media and product innovation.