bluuebunny/crossref_metadata_2025 huggingface dataset:
The Risk Factors Associated with the Incidence of Genital Warts in Iran
Authors: Nikoo Sara Talebipour , Lotfi Ali
Published: August 2023

Objective: Prevention of sexually transmitted diseases is an essential factor in managing diseases in the human population and increasing individuals’ and society’s health levels. Thus to increase our insufficient knowledge about proper prevention methods, we performed this study to assess the risk factors of the incidence of genital warts (GW).

Methods: In this case-control study, we enrolled 120 women and divided them into two groups. Sixty women with GW were set in the case group, and 60 healthy women were set in the control group. Afterwards, a questionnaire consisting of 13 questions regarding their life habituates was filled. The answers were analyzed using T-tests and chi-square test.

Findings: There was a statistically significant correlation between the incidence of GW and age (P-value ≤ 0.001*), the years passed from first intercourse (P-value =0.02*), and the history of venereal diseases (P-value =0.03*). However, the correlation between this disease and smoking, use of contraceptive medications, use of barrier and gravidity methods, marriage, education, the job of the individual and her partner, and the type of intercourse was not statistically significant.

Conclusion: It is interesting that although some factors may increase the risk of GW, some factors that one might reason should affect the prevalence of GW such as the use of barriers, marriage, and socioeconomics of the individuals had no significant effect on the prevalence of GW in this study.
Borsa İstanbul’da İlk Halka Arzların CRITIC Tabanlı OCRA Ve COPRAS Yöntemleri İle Analizi
Authors: ALTIN Hakan
Published: August 2023

Çalışmanın temel amacı, ilk halka arzlarda şirketlerin finansal rekabet gücünün ölçümü için Operational Competitiveness RAting Analysis (OCRA) ve COmplex PRoportional ASsessment (COPRAS) yöntemlerinin önerilmesidir. Bunun için ilk aşamada, Borsa İstanbul’da 2021 yılında ilk kez halka arz edilen şirketlerin OCRA yöntemine göre finansal rekabet güçleri hesaplanmıştır. Daha sonra, elde edilen bulguların doğruluğunun bir kanıtı olarak COPRAS yöntemine göre hesaplanmış bulgular ile karşılaştırılmıştır. Bu hesaplamalar için 19 alternatif şirket ve genel kabul görmüş 10 kriter kullanılmıştır. Ayrıca, kriterlerin önem ağırlıklarının belirlenmesi konusunda objektif bir değerlendirme ölçütü olan CRITIC yöntemi kullanılmıştır. Yöntemlerden elde edilen sıralama skorlarının arasındaki ilişki spearman sıra korelasyonu ile incelenmiştir. Buna göre, iki yöntemin sıralama skorları arasında bir sıralama yapılmadan önce yüzde 74,20 oranında pozitif yönlü kuvvetli bir ilişki vardır. Buna ilaveten, skorlar arasında büyükten küçüğe sıralama yapıldıktan sonra pozitif yönlü mutlak bir sıra korelasyon ilişki yaşanmaktadır. Elde edilen sonuçlar, istatistiksel olarak anlamlıdır.
Scientific Theory, Beliefs, Scissor Value Test and Single Event Inference
Authors: Dolgikh Serge
Published: August 2023

An ostensibly straightforward question: given an unknown probability distribution, what information can be inferred from a single positive observation, keeps returning in different domains and problems in the modern science, including the anthropic principle in fundamental physics and abiogenesis problem in astrobiology: estimating the unknown, as of present, probability of the emergence of life from non-biological environment. In this work we discuss common assumptions, beliefs and biases in the analysis of single event inference with the conclusion that the standard probabilistic interpretation and deterministic models are the only ones among the considered that have definite scientific value. As well, a test of scientific value is proposed for assumptions not based on existing knowledge, that is, beliefs, that allows to distinguish valuable beliefs with a potential to lead to new knowledge as a result of subsequent trials from those of insignificant value, due to inability to generate new knowledge.
Promoting trust in HAVs of following manual drivers through implicit and explicit communication during minimal risk maneuvers
Authors: Hub Fabian , Hess Silvio , Lau Merle , Wilbrink Marc , Oehl Michael
Published: August 2023

The successful integration of highly automated vehicles (HAV) in future mixed traffic environments will depend, among other things, on their seamless, safe, and accepted interaction with other road users. Therefore, appropriate combination of light signals, as external human-machine interface (eHMI), and driving behavior, as dynamic human-machine interface (dHMI), is required consistently in order to develop trust of following manual drivers in HAVs. Especially, in borderline traffic scenarios where HAVs are confronted with challenges, such as loss of connectivity, so-called minimal risk maneuvers (MRMs) are performed abruptly. Here, understanding communication via eHMI and dHMI is crucial for road safety, as drivers need to prepare for maneuvers themselves. Therefore, two consecutive, explorative online video studies were conducted. Firstly, the appropriate braking dynamics for an MRM were evaluated. Secondly, insights into the eHMI communication strategy of an HAV during an MRM were gained. The overall aim of this work is to present strategies for implicit and explicit communication channels of an HAV in order to promote learned trust during MRMs from the perspective of drivers who follow them. The results show that adding novel eHMI designs (e.g., warning sign, 360° LED light-band) to conventional light signals positively affects the user experience in a first contact interaction. The findings could have a positive impact on the development of trust in HAVs. In conclusion, specific eHMI communication strategies can be highly supportive for following manual drivers in MRM scenarios, which may lead to legislative considerations in the future.
A new integrative approach combining right heart catheterization and echocardiography to stage aortic stenosis-related cardiac damage
Authors: Viva Tommaso , Postolache Adriana , Nguyen Trung Mai-Linh , Danthine Pauline , Petitjean Hélène , Bruno Vito Domenico , Martinez Christophe , Lempereur Mathieu , Guazzi Marco , Aghezzaf Samy , Coisne Augustin , Oury Cécile , Dulgheru Raluca , Lancellotti Patrizio
Published: August 2023

Introduction

Although staging of the extent of aortic stenosis (AS)-related cardiac damages is usually performed via echocardiography, this technique has considerable limitations in assessing pulmonary artery and right chamber pressures. The present hypothesis-generating study sought to explore the efficacy of a staging system of cardiac damage based on echocardiographic and invasive [right heart catheterization (RHC)] hemodynamic parameters in patients undergoing transcatheter aortic valve implantation (TAVI).

Methods

We studied 90 symptomatic patients with severe AS in whom echocardiographic and invasive evaluation by RHC was obtained prior to TAVI. Cardiac damage stages were defined as follows: no cardiac damage (stage 0), left ventricular (LV) damage (stage 1), left atrial or mitral valve damage (stage 2), pulmonary vasculature or tricuspid valve damage (stage 3), and right ventricular (RV) dysfunction or low-flow state (stage 4). With the integrative approach using RHC, pulmonary hypertension (PH) was defined as an mPAP ≥25 mmHg and the low-flow state corresponded to a cardiac index of <1.8 L/min/m2 and a right atrial pressure of >10 mmHg.

Results

During follow-up (median: 2.9 years), 43 patients (47.8%) died. The integrative cardiac damage staging was associated with a significant increase in all-cause and cardiovascular mortality per each increase of cardiac damage stage, whereas the outcome was similar according to the echocardiographic staging.

Conclusions

A staging system of cardiac lesion based on echocardiographic and invasive hemodynamic parameters in patients with severe AS undergoing TAVI predicts mortality. Patients with pre-existing PH, ≥ moderate tricuspid regurgitation and/or RV dysfunction, and a low-flow state had a markedly increased risk of death. Further larger studies are needed to validate our findings.
Prediction of ablation zone disappearance after microwave ablation for the patients with papillary thyroid microcarcinoma using nomograph
Authors: Hu Cai , Liang Shuang , Liu Huahui , Yang Jing , Kang Haiyu , Guan Sainan , Yan Ronghua , Xu Erjiao
Published: August 2023

Objectives

To construct a prognostic nomogram to predict the ablation zone disappearance for patients with papillary thyroid microcarcinoma (PTMC) after microwave ablation (MWA).

Materials and methods

From April 2020 to April 2022, patients with PTMC who underwent MWA treatment were collected retrospectively. Ultrasound (US) or contrast-enhanced ultrasound (CEUS) was performed at 1 day, 1, 3, 6, 12, 18 and 24 months after MWA to observe the curative effect after ablation. The volume, volume reduction rate (VRR) and complete disappearance rate of the ablation zone at each time point were calculated. Univariate and multivariate logistic regression analysis were used to determine the prognostic factors associated with the disappearance of the ablation zone after MWA, and the nomogram was established and validated.

Results

72 patients with PTMCs underwent MWA were enrolled into this study. After MWA, no tumor progression (residual, recurrence or lymph node metastasis) and major postoperative complications occurred. The ablation zone in 28 (38.89%) patients did not completely disappear after MWA in the follow-up period. Three variables, including age (odds ratio [OR]: 1.216), calcification type (OR: 12.283), initial maximum diameter (OR: 2.051) were found to be independent prognostic factors predicting ablation zone status after MWA by multivariate analysis. The above variables and outcomes were visualized by nomogram (C-index=0.847).

Conclusions

MWA was a safe and effective treatment for PTMC. Older patients with macrocalcification and larger size PTMCs were more unlikely to obtain complete disappearance of ablation zones. Incomplete disappearance of ablation zone was not related to recurrence.
Serum IL-27 levels increase in subjects with hypothyroidism and are negatively correlated with the occurrence of nonalcoholic fatty liver disease
Authors: Wen Yahui , Zhang Heng , Yang Ning , Gao Xia , Chen Zhe , Liu Jia , Wang Guang
Published: August 2023

Background

The level of serum interleukin-27 (IL-27) was significantly decreased in the obesity group. After injection of IL-27, obese mice showed significant weight loss,reduced fat accumulation, improved insulin resistance and hepatic steatosis.IL-27 plays a key role in the regulation of metabolic processes, but there are scarce data on circulating IL-27 levels in hypothyroidism. The purpose of this study was to assess the serum levels of IL-27 in patients with hypothyroidism and its relationship with NAFLD.

Methods

185 participants were included in this cross-sectional survey. According to thyroid function, the subjects were classified into three groups: euthyroidism (n = 55), subclinical hypothyroidism (n = 53), and hypothyroidism (n = 77). Serum IL-27 concentrations were measured by ELISA.

Results

Serum IL27 levels were significantly higher in subclinical hypothyroidism and hypothyroidism groups than in the euthyroidism group. Serum IL27 levels had a negative correlation with HOMA-IR,FBG,TG, subcutaneous fat,and visceral fat, and had a positive correlation with HDL-C (P< 0.05). Furthermore, logistic regression analysis indicated that IL-27 levels, HOMA-IR, and visceral fat showed significant associations with NAFLD after complete adjustment (P< 0.05). ROC curves showed that theoptimal cut-off value of serum IL-27 for discriminating NAFLD was 95.87pg/mL. The area under the ROC curve was 77.3% (95% CI = 0.694-0.851, p < 0.001).

Conclusions

Serum IL-27 levels demonstrated a compensatory increase in patients with subclinical hypothyroidism or hypothyroidism and showed an independent association with NAFLD. Circulating IL-27 levels could predict the occurrence of NAFLD in hypothyroidism. These results suggested that altering the circulating levels of IL-27 may be a potential therapeutic target for NAFLD.
Novel molecular markers for Taxodium breeding from the chloroplast genomes of four artificial Taxodium hybrids
Authors: Yue Minghua , Chen Hong , Xuan Lei , Yang Ying , Chong Xinran , Li Mingzhi , Yu ChaoGuang , Lu Xiaoqing , Zhang Fan
Published: August 2023

Taxodium“Zhongshanshan” are a group of intraspecificTaxodiumhybrids with superparental dominance and high ecological and economic value in southern China. Identifying the parentage of hybrids, especially the male parent, is critically important for genetic studies. However, the large nuclear genomes of members of the genusTaxodiumpose a major challenge for the development of molecular markers. Here, we developed novel molecular markers by conducting a comparative analysis of the chloroplast genomes of four artificialTaxodiumhybrids and their parents. The lengths of the whole chloroplast genome ranged from 131,942 to 132,128 bp, and the total guanine (GC) content of the chloroplast genomes ranged from 34.6% to 35.81%. A total of 120 unique genes were identified, including 83 protein-coding genes, 33 transfer RNAs, and four ribosomal RNAs. There were 69‐71 simple sequence repeats were detected in the four hybrids. Phylogenetic analysis revealed that these hybrids clustered with their paternal parents. Similar findings were obtained by analysis of the GC content of protein-coding genes. Molecular markers were developed using the highly variable regions of the chloroplast genomes, and polymerase chain reaction (PCR) assays revealed that these markers were effective for identifying the male parents of these hybrids. Our findings indicate for the first time that the chloroplast genomes ofTaxodiumare paternally inherited. Generally, these molecular markers could facilitate breeding and genetic studies ofTaxodium.
A novel necroptosis-related long noncoding RNA model for predicting clinical features, immune characteristics, and therapeutic response in clear cell renal cell carcinoma
Authors: Zhang Lei , Chen Yongquan , Hu Weijing , Wu Bo , Ye Linfeng , Wang Dongwen , Bai Tao
Published: August 2023

Background

Necroptosis is an immune-related cell death pathway involved in the regulation of the tumor microenvironment (TME). Here, we aimed to explore the role of necroptosis in clear cell renal cell carcinoma (ccRCC) and construct a necroptosis-related lncRNA (NRL) model to assess its potential association with clinical characteristics and immune status.

Methods

Gene expression profiles and clinical data for ccRCC patients were obtained from the Cancer Genome Atlas (TCGA). Pearson’s correlation, univariate Cox, and least absolute shrinkage and selection operator analyses were used to develop an NRL model. Kaplan–Meier (K-M) and receiver operating characteristic (ROC) curve analyses were used to determine the prognostic value of the NRL model. The clinical information was used to assess the diagnostic value of the NRL model. The TME, immune function, immune cell infiltration, and immune checkpoints associated with the NRL model risk score were studied using the ESTIMATE, GSEA, ssGSEA, and CIBERSORT algorithms. The immunophenoscore (IPS) and half-maximal inhibitory concentration (IC50) were used to compare the efficacies of immunotherapy and chemotherapy based on the NRL model. Finally, in vitro assays were performed to confirm the biological roles of NRLs.

Results

A total of 18 necroptosis-related genes and 285 NRLs in ccRCC were identified. A four-NRL model was constructed and showed good performance in the diagnosis and prognosis of ccRCC patients. The ESTIMATE scores, tumor mutation burden, and tumor stemness indices were significantly correlated with NRL model risk score. Immune functions such as chemokine receptors and immune receptor activity showed differences between different risk groups. The infiltration of immunosuppressive cells such as Tregs was higher in high-risk patients than in low-risk patients. High-risk patients were more sensitive to immunotherapy and some chemotherapy drugs, such as sunitinib and temsirolimus. Finally, the expression of NRLs included in the model was verified, and knocking down these NRLs in tumor cells affected cell proliferation, migration, and invasion.

Conclusion

Necroptosis plays an important role in the progression of ccRCC. The NRL model we constructed can be used to predict the clinical characteristics and immune features of ccRCC patients.
Coaxially swirled porous disks flow simultaneously induced by mixed convection with morphological effect of metallic/metallic oxide nanoparticles
Authors: Raza Qadeer , Wang Xiaodong , Hassan Ahmed M. , Siddique Imran , Ali Bagh , Ali Irfan
Published: August 2023

This study focuses on the numerical modeling of coaxially swirling porous disk flow subject to the combined effects of mixed convection and chemical reactions. We conducted numerical investigations to analyze the morphologies of aluminum oxide (Al2O3) and copper (Cu) nanoparticles under the influence of magnetohydrodynamics. For the flow of hybrid nanofluids, we developed a model that considers the aggregate nanoparticle volume fraction based on single-phase simulation, along with the energy and mass transfer equations. The high-order, nonlinear, ordinary differential equations are obtained from the governing system of nonlinear partial differential equations via similarity transformation. The resulting system of ordinary differential equations is solved numerically by the Runge–Kutta technique and the shooting method. This is one of the most widely used numerical algorithms for solving differential equations in various fields, including physics, engineering, and computer science. This study investigated the impact of various nanoparticle shape factors (spherical, platelet and laminar) subject to relevant physical quantities and their corresponding distributions. Our findings indicate that aluminum oxide and copper (Al2O3-Cu/H2O) hybrid nanofluids exhibit significant improvements in heat transfer compared to other shape factors, particularly in laminar flow. Additionally, the injection/suction factor influences the contraction/expansion phenomenon, leading to noteworthy results concerning skin friction and the Nusselt number in the field of engineering. Moreover, the chemical reaction parameter demonstrates a remarkable influence on Sherwood’s number. The insights gained from this work hold potential benefits for the field of lubricant technology, as they contribute valuable knowledge regarding the behavior of hybrid nanofluids and their associated characteristics.
Treatment outcomes and associated factors among tuberculosis patients attending Gurage Zone Public Hospital, Southern Nations, Nationalities, and People's Region, Ethiopia: an institution-based cross-sectional study
Authors: Agazhu Haile Workye , Assefa Zebene Mekonnen , Beshir Masino Tessu , Tadesse Habtam , Mengstie Aregash Sitot
Published: August 2023

Background

Tuberculosis remains the most important global health problem. Worldwide, tuberculosis is the cause of a single infectious agent and the ninth leading cause of death, ranking above human immunodeficiency virus. In high-burden settings, one of the mechanisms to control tuberculosis is to identify patients' problems during treatment. Nevertheless, the problem is still a countrywide issue, and there is a shortage of research to show treatment outcomes and associated factors of tuberculosis in Southern Nations, Nationalities, and People's Regions in the Gurage Zone.

Methods

An institution-based, cross-sectional study was conducted to collect data from 347 medical records of tuberculosis patients from 20 July 2016 to 30 July 2021 at Gurage Zone Public Hospitals. The tool includes data about socio-demographic characteristics, as well as tuberculosis-related, and tuberculosis treatment outcome status. Data were analyzed using SPSS version 26, and multivariable logistic regression analyses were conducted to identify significantly associated variables with successful tuberculosis treatment outcomes. The adjusted odds ratio (AOR) with its 95% confidence interval (CI) at a p-value of < 0.05 was used to claim statistical association.

Results

In this study, the overall prevalence of successful tuberculosis treatment outcomes was 79.3%. HIV-negative tuberculosis patients (AOR = 4.33; 95% CI: 1.91, 9.79), patients aged < 20 years (AOR = 0.16; 95% CI: 0.04, 0.74), and married participants (AOR = 0.29; 95% CI: 0.10, 0.88) were significantly associated with successful tuberculosis treatment outcomes.

Conclusion and recommendations

The prevalence of successful tuberculosis treatment outcomes was low. HIV-TB co-infection, single marital status, and age >20 years negatively affected the treatment outcomes of tuberculosis, thus more effort and better attention should be given to better outcomes of tuberculosis patients, especially for HIV-TB co-infected participants.
Differences in microbial community structure and metabolic activity among tea plantation soils under different management strategies
Authors: Li Guoyou , Zhu Shaoxian , Long Jiang , Mao Honglin , Dong Yonghong , Hou Yan
Published: August 2023

Introduction

Microorganisms play an important role in the multifunctionality of soil ecosystems. Soil microbial diversity and functions have a great impact on plant growth and development. The interactions between tea trees and soil microbiota can be linked with planting patterns and management strategies, whose effects on soil microbial community structure and metabolites are still unclear.

Methods

Here we used amplicon sequencing and metabolomic analysis to investigate the differences in soil microbial composition and metabolites among three tea production systems: organic, non-organic, and intercropping.

Results

We detected significant differences among the three systems and found that Firmicutes, Proteobacteria, Acidobacteriota, Actinobacteriota and Chloroflexi were the main bacteria in the three soil groups, although they varied in relative abundance. Acidobacteria bacterium increased significantly in the organic and intercropping groups. For fungi, Ascomycota and Basidiomycota were the main differential fungal phyla. Fungi alpha-diversity in the non-organic group was significantly higher than that in the other two groups, and was correlated with multiple soil physical and chemical factors. Moreover, network analysis showed that bacteria and fungi were strongly correlated. The changes in soil microorganisms caused by management and planting patterns may affect soil quality through corresponding changes in metabolites. Metabolomic analysis showed differences in metabolite composition among different groups. It was also found that the arachidonic acid metabolic pathway was affected by changes in soil microorganisms, and may further affect soil quality in an essential manner.

Discussion

Planting patterns and management strategies may significantly affect soil microorganisms and therefore metabolites. Changes in soil microorganisms, especially in fungi, may alter soil quality by affecting soil physicochemical properties and metabolites. This study will provide new insights into soil quality monitoring from a microbiological perspective.
Precision medicine in neurodegeneration: the IHI-PROMINENT project
Authors: Tate Ashley , Suárez-Calvet Marc , Ekelund Mats , Eriksson Sven , Eriksdotter Maria , Van Der Flier Wiesje M. , Georges Jean , Kivipelto Miia , Kramberger Milica G. , Lindgren Peter , López Juan Domingo Gispert , Lötjönen Jyrki , Persson Sofie , Pla Sandra , Solomon Alina , Thurfjell Lennart , Wimo Anders , Winblad Bengt , Jönsson Linus ,   on behalf of the PROMINENT consortium
Published: August 2023

Neurodegenerative diseases are one of the most important contributors to morbidity and mortality in the elderly. In Europe, over 14 million people are currently living with dementia, at a cost of over 400 billion EUR annually. Recent advances in diagnostics and approval for new pharmaceutical treatments for Alzheimer’s disease (AD), the most common etiology of dementia, heralds the beginning of precision medicine in this field. However, their implementation will challenge an already over-burdened healthcare systems. There is a need for innovative digital solutions that can drive the related clinical pathways and optimize and personalize care delivery. Public-private partnerships are ideal vehicles to tackle these challenges. Here we describe the Innovative Health Initiative (IHI) public-private partnership project PROMINENT that has been initiated by connecting leading dementia researchers, medical professionals, dementia patients and their care partners with the latest innovative health technologies using a precision medicine based digital platform. The project builds upon the knowledge and already implemented digital tools from several collaborative initiatives that address new models for early detection, diagnosis, and monitoring of AD and other neurodegenerative disorders. The project aims to provide support to improvement efforts to each aspect of the care pathway including diagnosis, prognosis, treatment, and data collection for real world evidence and cost effectiveness studies. Ultimately the PROMINENT project is expected to lead to cost-effective care and improved health outcomes.
Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies
Authors: Constable Paul A. , Lim Jeremiah K. H. , Thompson Dorothy A.
Published: August 2023

The retina and brain share similar neurochemistry and neurodevelopmental origins, with the retina, often viewed as a “window to the brain.” With retinal measures of structure and function becoming easier to obtain in clinical populations there is a growing interest in using retinal findings as potential biomarkers for disorders affecting the central nervous system. Functional retinal biomarkers, such as the electroretinogram, show promise in neurological disorders, despite having limitations imposed by the existence of overlapping genetic markers, clinical traits or the effects of medications that may reduce their specificity in some conditions. This narrative review summarizes the principal functional retinal findings in central nervous system disorders and related mouse models and provides a background to the main excitatory and inhibitory retinal neurotransmitters that have been implicated to explain the visual electrophysiological findings. These changes in retinal neurochemistry may contribute to our understanding of these conditions based on the findings of retinal electrophysiological tests such as the flash, pattern, multifocal electroretinograms, and electro-oculogram. It is likely that future applications of signal analysis and machine learning algorithms will offer new insights into the pathophysiology, classification, and progression of these clinical disorders including autism, attention deficit/hyperactivity disorder, bipolar disorder, schizophrenia, depression, Parkinson’s, and Alzheimer’s disease. New clinical applications of visual electrophysiology to this field may lead to earlier, more accurate diagnoses and better targeted therapeutic interventions benefiting individual patients and clinicians managing these individuals and their families.
Chemotherapy-induced toxic epidermal necrolysis in a patient with multiple myeloma, a case report and literature review
Authors: X Rui , W Meidan , W Gongqiang , Z Longyi , W Xiaoxia , C Wei , W Chenhui
Published: August 2023

Rationale and patient concerns

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are severe drug-induced skin reactions associated with a high mortality rate. The patient in this case report developed TEN after receiving the Velcade-lenalidomide-dexamethasone (VRD) regimen for the treatment of multiple myeloma (MM). The patient’s concerns included the progression of the rash, pain, itching, and potential long-term complications. TEN is a life-threatening condition that requires prompt medical intervention and hospitalization.

Interventions

The treatment approach for the patient included discontinuation of the causative medication (lenalidomide) and comprehensive supportive therapy. Supportive measures included the administration of systemic corticosteroids (methylprednisolone), intravenous immunoglobulin infusion, pain relief medication (ebastine), antibiotic prophylaxis, laminar bed use, and regular dressing changes. The goal was to alleviate symptoms, promote skin and mucous membrane healing, and prevent complications such as infection.

Diagnosis

The patient was diagnosed with stage III A DS and stage III ISS MM, specifically of the immunoglobulin G (λ) type. Diagnostic procedures included CT and MRI scans, bone marrow testing through flow cytometry and morphology analysis, and laboratory tests to assess blood markers. The diagnosis of TEN was made based on the clinical presentation, skin biopsy, and exclusion of other potential causes.

Outcomes

With the implemented interventions, the patient’s condition gradually improved, and the rash resolved without any residual scarring. The patient’s skin and mucosa healed, blood markers improved, and bone pain was relieved. The patient was discharged within a month of receiving the final treatment with bortezomib and dexamethasone. The patient got partial response(PR) of multiple myeloma.

Lessons

Drug-induced SJS/TEN is more prevalent in Asian populations, potentially due to differences in human leukocyte antigen (HLA) alleles. The use of systemic corticosteroid therapy in SJS/TEN cases is controversial due to the potential risks of immune suppression and complications. Balancing the immune response to prevent SJS/TEN while maintaining an effective cytotoxic immune response for tumor control remains a challenge. Lenalidomide, an immunomodulatory agent, can enhance antitumor immune responses but also contribute to the pathogenesis of SJS/TEN. Increased awareness of HLA variations and frequently mutated genes in different malignancies can help prevent SJS/TEN and improve patient outcomes.
Alleviation of hippocampal necroptosis and neuroinflammation by NecroX-7 treatment after acute seizures
Authors: Roh Yihyun , Lee Su Bin , Kim Minseo , Kim Mi-Hye , Kim Hee Jung , Cho Kyung-Ok
Published: August 2023

Temporal lobe epilepsy (TLE) is one of the most common neurological disorders, but still one-third of patients cannot be properly treated by current medication. Thus, we investigated the therapeutic effects of a novel small molecule, NecroX-7, in TLE using both a low [Mg2+]o-induced epileptiform activity model and a mouse model of pilocarpine-induced status epilepticus (SE). NecroX-7 post-treatment enhanced the viability of primary hippocampal neurons exposed to low [Mg2+]o compared to controls in an MTT assay. Application of NecroX-7 after pilocarpine-induced SE also reduced the number of degenerating neurons labelled with Fluoro-Jade B. Immunocytochemistry and immunohistochemistry showed that NecroX-7 post-treatment significantly alleviated ionized calcium-binding adaptor molecule 1 (Iba1) intensity and immunoreactive area, while the attenuation of reactive astrocytosis by glial fibrillary acidic protein (GFAP) staining was observed in cultured hippocampal neurons. However, NecroX-7-mediated morphologic changes of astrocytes were seen in both in vitro and in vivo models of TLE. Finally, western blot analysis demonstrated that NecroX-7 post-treatment after acute seizures could decrease the expression of mixed lineage kinase domain-like pseudokinase (MLKL) and phosphorylated MLKL (p-MLKL), markers for necroptosis. Taken all together, NecroX-7 has potential as a novel medication for TLE with its neuroprotective, anti-inflammatory, and anti-necroptotic effects.
EGFR is a potential dual molecular target for cancer and Alzheimer’s disease
Authors: Choi Hee-Jeong , Jeong Yoo Joo , Kim Jieun , Hoe Hyang-Sook
Published: August 2023

Many researchers are attempting to identify drugs that can be repurposed as effective therapies for Alzheimer’s disease (AD). Several recent studies have highlighted epidermal growth factor receptor (EGFR) inhibitors approved for use as anti-cancer drugs as potential candidates for repurposing as AD therapeutics. In cancer, EGFR inhibitors target cell proliferation and angiogenesis, and studies in AD mouse models have shown that EGFR inhibitors can attenuate amyloid-beta (Aβ) pathology and improve cognitive function. In this review, we discuss the different functions of EGFR in cancer and AD and the potential of EGFR as a dual molecular target for AD diseases. In addition, we describe the effects of anti-cancer EGFR tyrosine kinase inhibitors (TKIs) on AD pathology and their prospects as therapeutic interventions for AD. By summarizing the physiological functions of EGFR in cancer and AD, this review emphasizes the significance of EGFR as an important molecular target for these diseases.
The potential for mitochondrial therapeutics in the treatment of primary open-angle glaucoma: a review
Authors: Kuang Grace , Halimitabrizi Mina , Edziah Amy-Ann , Salowe Rebecca , O’Brien Joan M.
Published: August 2023

Glaucoma, an age-related neurodegenerative disease, is characterized by the death of retinal ganglion cells (RGCs) and the corresponding loss of visual fields. This disease is the leading cause of irreversible blindness worldwide, making early diagnosis and effective treatment paramount. The pathophysiology of primary open-angle glaucoma (POAG), the most common form of the disease, remains poorly understood. Current available treatments, which target elevated intraocular pressure (IOP), are not effective at slowing disease progression in approximately 30% of patients. There is a great need to identify and study treatment options that target other disease mechanisms and aid in neuroprotection for POAG. Increasingly, the role of mitochondrial injury in the development of POAG has become an emphasized area of research interest. Disruption in the function of mitochondria has been linked to problems with neurodevelopment and systemic diseases. Recent studies have shown an association between RGC death and damage to the cells’ mitochondria. In particular, oxidative stress and disrupted oxidative phosphorylation dynamics have been linked to increased susceptibility of RGC mitochondria to secondary mechanical injury. Several mitochondria-targeted treatments for POAG have been suggested, including physical exercise, diet and nutrition, antioxidant supplementation, stem cell therapy, hypoxia exposure, gene therapy, mitochondrial transplantation, and light therapy. Studies have shown that mitochondrial therapeutics may have the potential to slow the progression of POAG by protecting against mitochondrial decline associated with age, genetic susceptibility, and other pathology. Further, these therapeutics may potentially target already present neuronal damage and symptom manifestations. In this review, the authors outline potential mitochondria-targeted treatment strategies and discuss their utility for use in POAG.
Effects of different phenylcapsaicin doses on neuromuscular activity and mechanical performance in trained male subjects: a randomized, triple-blinded, crossover, placebo-controlled trial
Authors: Jiménez-Martínez Pablo , Sánchez-Valdepeñas Juan , Cornejo-Daza Pedro J. , Cano-Castillo Clara , Asín-Izquierdo Iván , Alix-Fages Carlos , Pareja-Blanco Fernando , Colado Juan C.
Published: August 2023

Objective:This study aimed to examine the effects of phenylcapsaicin (PC) supplementation on strength performance and neuromuscular activity in young trained male subjects.

Materials and methods:A total of 25 trained subjects [full-squat (SQ) one repetition maximum (1RM) = 125.6 ± 21.0 kg] were enrolled in this randomized, triple-blinded, crossover, placebo-controlled trial. The subjects performed a first session and a post-24 h session for each condition. In the first session, the subjects ingested a high dose of PC (HD, 2.5 mg), a low dose (LD, 0.625 mg), or a placebo (PLA). Their performance in SQ was assessed under a 3% × 8 × 70% 1RM protocol in the first session. Their performances in countermovement jump (CMJ), SQ with 60% 1RM, and isometric squat were measured before and after the SQ protocol in both sessions. The neural activity of the vastus lateralis (VL) and vastus medialis (VM) was recorded via surface electromyography (EMG) and averaged in both sessions.

Results:Significant differences between the conditions were reported for lifting velocity, velocity loss, and the 60% load in dynamic SQ (prange = 0.02–0.04). Electrical changes were not identified for any outcome, although neural activity changed across time (prange ≤0.001–0.006). A significant condition × time effect was observed in CMJ compared to PLA (p≤0.001) and LD (p≤0.001). Intra-set analyses revealed higher velocities in HD compared to those in LD (p= 0.01) and PLA (prange = 0.004–0.008).

Conclusion:Therefore, PC may improve the strength performance and attenuate the mechanical fatigue induced by resistance training in SQ and CMJ exercises.
Effects of exercise on body mass index and waist circumference of individuals with intellectual and developmental disabilities: a systematic review with meta-analysis
Authors: Jacinto Miguel , Monteiro Diogo , Antunes Raul , Ferreira José Pedro , Matos Rui , Campos Maria João
Published: August 2023

Introduction/Methods: This systematic review with meta-analysis aims to assess the magnitude of the effects of physical exercise programs on body mass index (BMI) and waist circumference (WC) of individuals with Intellectual and Developmental Disabilities (IDD), metabolic and cardiovascular health markers.

Results: Considering the eligibility criteria, a final sample of nine articles was obtained. For BMI, the Z-value obtained to test the null hypothesis (difference between means is zero), showed a Z = −2.176 and p = 0.03. The highest magnitude of the effect was from the intervention with combined training (difference in means: −0.399), with a value of Z = −1.815 and p = 0.07. For WC, the Z-value is zero, showing a Z = −3.306 and p = 0.001. The highest magnitude of the effect was from the intervention with continuous cardiorespiratory training of −0.786, with a value of Z = −2.793 and p = 0.005.

Discussion: Physical exercise prevents increases in BMI and WC in individuals with IDD. Aerobic training seems to be more effective in promoting WC and combined training in BMI.

Systematic Review Registration: [PROSPERO], identifier [CRD42021255316].
Psychiatric referrals to the general hospital emergency department: are we being effective?
Authors: Keller Shikma , Tilbor Einat , Shwiki Afnan , Florentin Sharon , Laufer Sofia , Bonne Omer , Canetti Laura , Reuveni Inbal
Published: August 2023

Introduction

General hospital emergency departments (GHEDs) are notoriously overcrowded. This is caused, in part, by ineffective referrals, that is to say referrals that do not require medical examination or other interventions in the context of a general hospital. This study aims to investigate the contribution of psychiatric referrals to this issue, to identify potential determinants of these referrals and offer means to reduce them.

Materials and methods

Retrospective data were collected from psychiatric admission files within a GHED of a tertiary-care city hospital over a 1 year period. Two experienced clinicians separately reviewed each file to determine rationale of referrals according to predetermined criteria.

Results

A total of 2,136 visits included a psychiatric examination, 900 (42.1%) were determined “effective,” and 1,227 (57.4%) were deemed “potentially ineffective.” The leading causes for potentially ineffective referrals to a GHED were psychiatric illness exacerbation (43.4%), and suicidal ideations (22%). Most referrals (66.9%) were initiated by the patient or their family, and not by a primary care physician or psychiatrist.

Conclusion

More than half of the psychiatric referrals did not necessarily require the services of a general hospital, and may be more suitable for referral to a dedicated psychiatric facility. Ineffective referrals to the GHED pose a burden on general hospital resources, and may be less effective for the psychiatric patients. This calls for clear guidelines for the provision of optimal emergency treatment for mental-health patients.
Breast cancer screening and diagnosis in older adults women in Brazil: why it is time to reconsider the recommendations
Authors: Rocha Aline Ferreira Bandeira Melo , Freitas-Junior Ruffo , Soares Leonardo Ribeiro , Ferreira Glalber Luiz Rocha
Published: August 2023

Introduction

Breast cancer screening in women of 70 years of age or older remains controversial due to a lack of studies that include women of this age.

Methods

This ecological study evaluated data from the Brazilian National Health Service (SUS) on breast cancer screening and staging in this age group compared to 50–69-year olds, for Brazil as a whole and for its geographical regions, between 2013 and 2019. A secondary database was obtained from the outpatient data system of the SUS’s Informatics Department, the Brazil Oncology Panel, the Brazilian Institute of Geography and Statistics, the Supplementary Health Agency and the Online Mortality Atlas.

Results

There was a marked reduction in screening in women ≥70 years of age (annual percent change [APC] –3.5; p < 0.001) compared to those of 50–69 years of age (APC-2.2; p = 0.010). There was a trend towards an increase in clinical staging, with a greater occurrence of stages III and IV in the ≥70 group (44.3%) compared to the women of 50–69 years of age (40.8%; p < 0.001).

Conclusion

Considering the increasing age of the Brazilian population and the heterogeneity among older adults women, screening for the over-70s within the SUS merits greater debate insofar as the implementation of public policies is concerned.
Efficient reciprocating burrowing with anisotropic origami feet
Authors: Kim Sareum , Treers Laura K. , Huh Tae Myung , Stuart Hannah S.
Published: August 2023

Origami folding is an ancient art which holds promise for creating compliant and adaptable mechanisms, but has yet to be extensively studied for granular environments. At the same time, biological systems exploit anisotropic body forces for locomotion, such as the frictional anisotropy of a snake’s skin. In this work, we explore how foldable origami feet can be used to passively induce anisotropic force response in granular media, through varying their resistive plane. We present a reciprocating burrower which transfers pure symmetric linear motion into directed burrowing motion using a pair of deployable origami feet on either end. We also present an application of the reduced order model granular Resistive Force Theory to inform the design of deformable structures, and compare results with those from experiments and Discrete Element Method simulations. Through a single actuator, and without the use of advanced controllers or sensors, these origami feet enable burrowing locomotion. In this paper, we achieve burrowing translation ratios—net forward motion to overall linear actuation—over 46% by changing foot design without altering overall foot size. Specifically, anisotropic folding foot parameters should be tuned for optimal performance given a linear actuator’s stroke length.
The Power of Virtual Influencers: Impact on Consumer Behaviour and Attitudes in the Age of AI
Authors: Gerlich Michael
Published: August 2023

In recent years, a new type of influencer has emerged in the field of social media marketing: virtual influencers. Though it is spreading fast, the trend is still new and, therefore, limited research has been conducted on the topic. This study aims to investigate the impact of virtual influencers on customers and whether there is a direct impact on human influencers due to the rise of virtual influencers in the industry. The study employed a questionnaire-based survey method to collect and analyse responses from a sample of 357 participants. The questions focus on trust, credibility, expertise, and contribution to purchase intention by the virtual influencers. The results indicate that customers are increasingly attracted to virtual influencers and that virtual influences are perceived as more trustworthy, credible, and relevant to customers’ preferences, leading to an increase in purchase intention. The study also discusses the implications of these findings for managers designing marketing campaigns.
Witnessing Sexual Harassment and Associated Substance Use and Poor Mental Health Outcomes among Adolescent Girls in the US
Authors: Reed Elizabeth , Salazar Marissa , Behar Alma , Agah Niloufar , Wong Alice , Silverman Jay , Rusch Melanie , Raj Anita
Published: August 2023

Direct experiences of sexual harassment have been found to be associated with substance use and poor mental health among girls. Indirect experiences, such as witnessing the sexual harassment of others, may be indicative of a climate supportive of sexual harassment against girls and elicit similar adverse outcomes. The current study sought to assess reports of witnessing sexual harassment and associations with substance use and mental heath outcomes among adolescent girls. The data were from questionnaires among girls (n = 152) ages 15–19 recruited from a health clinic serving a low-resource community in San Diego County. Using crude and adjusted regression models, we assessed witnessing the sexual harassment of girls (past year) as well as the frequency of witnessing such acts in relation to substance use, anxiety, depression, and suicidal ideation. The adjusted models included demographics and direct experiences of sexual harassment (past 6 months) as covariates. The participants had an average age of 17, and 76% were Latina. The majority (70%) reported witnessing sexual harassment (past year); 65% reported directly experiencing sexual harassment (past 6 months). Among those reporting witnessing, most witnessed sexual harassment at school (69%), at a party (45%), in their neighborhood (34%), or on public transport (33%). In adjusted logistic regression models, witnessing sexual harassment was significantly associated with past 30-day alcohol use, ever using drugs, feeling depressed (past 30 days), feeling anxious (past 30 days), and past-year suicidal ideation (ORs range 2.9–18.2). The findings suggest that, in addition to direct experiences of sexual harassment, indirect experiences of witnessing the sexual harassment of others may also be associated with negative outcomes regarding girls’ health and well-being.
Optimal Sand−Paving Parameters Determination of an Innovatively Developed Automatic Maize Seeding Machine
Authors: Fu Bohan , Sun Weizhong , Zhang Zhao
Published: August 2023

Maize is an important crop to ensure food safety. High-quality seeds can guarantee a good yield. The maize seed germination rate is the most important information for the maize industry, which can be obtained through the seed germination test. An essential stage in determining the germination rate is the planting of the seeds. The current seed planting process is fully manual, which is labor-intensive and costly, and it requires the development of an autonomous seeding machine. This research developed an automatic maize seeding machine, consisting of four operations: paving sand, seed layout, watering, and covering the seed. Among the four procedures, sand paving is a crucial step, the performance of which is affected by the gate opening size, conveyor speed, and sensor mounting location. Three performance evaluating factors are the weight of sand in the tray, the volume of sand left on the conveyor, and sand surface flatness. A full factorial experiment was designed with three variables and three levels to determine an appropriate factor combination. RGB-D information was used to calculate the volume of sand left on the conveyor and sand flatness. An analytic hierarchy process was employed to assign weights to the three evaluation indicators and score the various combinations of factors. The machine for paving sand achieved a satisfactory result with an opening size of 10.8 mm, a sensor distance of 9 cm, and a conveyor belt speed of 5.1 cm/s. With the most satisfactory factors determined, the machine shows superior performance to better meet practical applications.