bluuebunny/crossref_metadata_2025 huggingface dataset:
There is no dose–response relationship between the amount of exercise and improvement in HbA1c in interventions over 12 weeks in patients with type 2 diabetes: a meta-analysis and meta-regression
Authors: Wrench Elizabeth , Rattley Kate , Lambert Joel E. , Killick Rebecca , Hayes Lawrence D. , Lauder Robert M. , Gaffney Christopher J.
Published: August 2022

Aims

Aerobic exercise is well recognised as an effective treatment for people with type 2 diabetes but the optimal amount of aerobic exercise to improve glycaemic control remains to be determined. Thus, the aim of this meta-analysis and meta-regression was to assess the impact of volume and intensity of aerobic exercise on glycaemic control.

Methods

Medline, Cochrane, Embase, and Web of Science databases were searched up until 15 December 2020 for the terms “aerobic exercise AND glycaemic control”, “type 2 diabetes AND exercise”, and “exercise AND glycaemic control AND Type 2 diabetes AND randomised control trial”. We included (i) randomised control trials of ≥ 12 weeks, (ii) trials where participants had type 2 diabetes and were aged 18 or over, and (iii) the trial reported HbA1c concentrations pre- and post-intervention. Two reviewers selected studies and extracted data. Data are reported as standardised mean difference (SMD) and publication bias was assessed using funnel plots.

Results

A total of 5364 original titles were identified. Sixteen studies were included in the meta-analysis. Aerobic exercise reduced HbA1c versus control (SMD = 0.56 (95% CI 0.3–0.82), p < 0.001). There were also significant reductions in BMI (SMD = 0.76 (95% CI 0.25–1.27), p < 0.05). There was no dose–response relationship between improvement in HbA1c and the intensity and volume of the intervention (p > 0.05).

Conclusions

Twelve-week or longer aerobic exercise programmes improve glycaemic control and BMI in adults with type 2 diabetes. Longer or more intense interventions appear to confer no additional benefit on HbA1c.
Exercise Self-Efficacy and patient global assessment were associated with 6-min walk test distance in persons with rheumatoid arthritis
Authors: Houge Ingrid Sæther , Hoff Mari , Halsan Oddrun , Videm Vibeke
Published: August 2022

Introduction

Low functional capacity is related to future loss of daily function and cardiovascular events. The present study explored the associations of patient-reported outcome measures (PROMs) and disease-specific measures with functional capacity as measured by the 6-min walk test (6MWT) in persons with rheumatoid arthritis (RA).

Methods

Seventy-nine participants from rheumatology outpatient clinics were included. The distance walked during the 6MWT (6MWD) was the dependent variable in multivariable regression analyses. Model 1 included the independent variables sex, age (in tertiles to improve model fit), and body mass index (BMI). Building on Model 1, Model 2 added smoking, patient global assessment (PGA), Exercise Self-Efficacy, Hospital Anxiety and Depression Scale’s Depression score, and Cohen’s Perceived Stress Scale score, whereas Model 3 added smoking, disease duration, present use of glucocorticosteroids, seropositivity, Disease Activity Score 28—C-Reactive Protein (DAS28-CRP), and a comorbidity variable.

Results

Median age was 65 years, 76% were female, and median 6MWD was 493 m. In Model 1, BMI and age were significantly associated with the 6MWD (R2 = 0.42). In Model 2, PGA and Exercise Self-Efficacy were also significantly associated with the 6MWD, with standardized regression coefficients of − 0.21 (p = 0.03) and 0.26 (p = 0.004) respectively (R2 = 0.54). The RA-specific variables in Model 3 were not significantly associated with the 6MWD (R2 = 0.49).

Conclusion

The PROMs PGA and Exercise Self-Efficacy were significantly associated with functional capacity as measured by the 6MWT in persons with RA, whereas disease-specific measures such as DAS28-CRP and disease duration were not.

Key Points• Functional capacity measured with the 6-minute walk test was significantly associated with body mass
index, age, patient global assessment, and Exercise Self-Efficacy in persons with RA.• Patient-reported outcome measures explained more of the variation in functional capacity than objective
or composite measures of disease and are relevant measures in clinical follow-up.• Techniques that enhance self-efficacy for exercise should be incorporated into clinical practice to
promote physical activity.
Presence of spraint at bridges as an effective monitoring tool to assess current Eurasian fish otter distribution in Austria
Authors: Schenekar Tamara , Clark Adam , Holzinger Werner E. , Weiss Steven J.
Published: August 2022

Monitoring carnivore populations requires sensitive and trustworthy assessment methods to make reasonable and effective management decisions. The Eurasian fish otter Lutra lutra experienced a dramatic population decline throughout Europe during the twentieth century but is currently recovering in both distribution range and population size. In Austria, most assessments on otter distribution have applied a modified version of the so-called “British” or “standard” method utilizing point-wise surveys for otter spraints at predefined monitoring bridges. In this study, we synthesize several recent statewide assessments to compile the current otter distribution in Austria and evaluate the efficiency and sensitivity of the “monitoring bridge” approach in comparison to the “standard” method. The otter shows an almost comprehensive distribution throughout eastern and central Austria, while more western areas (Tyrol and Vorarlberg) are only partially inhabited, likely due to a still ongoing westward expansion. Furthermore, the bridge monitoring method utilizing presence/absence information on otter spraints reveals itself to be a time- and cost- effective monitoring tool with a tolerable loss of sensitivity for large-scale otter distribution assessments. Count data of spraints seem to be prone to observer bias or environmental influences like weather or flooding events making them less suitable for quantitative analyses.
The anti-inflammatory effect of myrrh ethanolic extract in comparison with prednisolone on an autoimmune disease rat model induced by silicate
Authors: ElMosbah Dina E. , Khattab Marwa S. , Emam Shimaa R. , Miniawy Hala M. F. El
Published: August 2022

Autoimmune disease is a complex chronic disease that triggers immune activation against autoantigens resulting in tissue damage. Epidemiological data showed that autoimmune diseases are increasing worldwide over the last decades owing to increased environmental pollution. This study investigates the therapeutic effect of myrrh as a natural medicine compared to prednisolone in the treatment of immune-mediated glomerulonephritis induced by silicate. The autoimmune disease model in rats was induced by injecting 5 mg crystalline sodium silicate suspension subcutaneously once weekly for 20 weeks, and then the rats were treated either with myrrh extract or prednisolone or with both for 6 weeks. Liver and kidney function tests, histopathology, and immunohistochemistry of TNF-α expression in kidney tissue were performed. The creatinine significantly elevated in silica-treated group and decreased in other treated groups. Histopathology of the kidney revealed improvement of glomerular and tubular basement thickness in all treated groups, but the inflammatory cell count slightly decreased in the group treated with myrrh than the other treated groups which showed a marked decrease. TNF-α expression was significantly decreased in all treated groups. Interestingly, the myrrh did not produce hepatic lesions and improve the side effect of prednisolone in the liver when taken in combination. Therefore, myrrh extract possessed anti-inflammatory properties and counteracted the side effect of prednisolone on the liver. Myrrh extract can serve as a conjunctive therapy with prednisolone to treat autoimmune diseases.
Thermoluminescence characteristics of different phase transitions from nanocrystalline alumina
Authors: Abdou N. Y. , Sabry Mohamed , El-Faramawy Nabil
Published: August 2022

Nanocrystalline boehmite material was synthesized using the hydrothermal method. Different annealing temperatures have been used to transform boehmite into different alumina phases to study the effect of different phase transitions on the thermoluminescence properties of alumina. XRD analysis was carried out to investigate the crystal structure of the different alumina phases. The thermoluminescence glow curves for different alumina phases showed different structures; however, the sensitivity was almost constant for all the phase transitions of alumina over the applied dose ranging from 0.55 to 330 Gy.
Techno-economic analysis of a PV/T waste heat–driven compound ejector-heat pump for simultaneous data centre cooling and district heating using low global warming potential refrigerants
Authors: Al-Sayyab Ali Khalid Shaker , Navarro-Esbrí Joaquín , Barragán-Cervera Angel , Mota-Babiloni Adrián
Published: August 2022

A comprehensive techno-economic evaluation is evaluated based on an innovative compound ejector-heat pump system with PV/T (photovoltaic thermal) waste heat-driven. The aim of the system is simultaneous data centre cooling and waste heat recovery for district heating to reduce residential greenhouse gas emissions. The new system avoids the ejector pump by combining PV/T waste heat with an evaporative-condenser as an ejector driving force, considering several low global warming potential alternatives to R134a. The simulation indicates that the proposed system presents a remarkable difference in all investigated refrigerants’ overall system coefficient of performance (COP). Particularly, R515B presents the highest increase in COP, 54% and 49% in cooling and heating modes, respectively. It also provides the highest electricity consumption reduction, 84.1 MWh yearly. Moreover, the system improves the data centre power usage effectiveness (PUE) index from 10 to 19%. In financial terms, the shortest payback period (6.3 years) is obtained with R515B, followed by R515A and R1234ze(E).
Organic carbon compounds associated with deep soil carbon stores
Authors: Sangmanee Podjanee , Dell Bernard , Harper Richard J. , George Suman , Henry David J.
Published: August 2022

Aims

Organic carbon has been reported in deep regolithic profiles to depths of tens of metres, but the composition of the carbon compounds is unknown.

Methods

Residual carbon in the form of non-volatile low molecular weight compounds (LMWC) was characterised in three deep soil profiles to a depth of 19 m under farmland in south-western Australia following extraction with ethyl acetate and analysis by GC/MS. Pyrolysis and off-line thermochemolysis were used to characterise macromolecular organic carbon (MOC) to a depth of 29 m at a fourth site.

Results

Three compound classes occurred across the three different field locations: (1) terpenes, (2) fatty acids, amides and alcohols, and (3) plant steroids; indicating the influence of input of the past and present vegetation. Compounds related to fatty acids were the predominant residual carbon species in deep soils, and may be derived from plants and microorganisms. Biomarkers such as lignin, polysaccharides, proteins and terpenes at 0–0.1 m implied influences of vegetation, fire events and microorganisms. Pyrolysis found that polysaccharides were distributed mainly from 0 to 0.1 m, while aromatic compounds were consistently detected down to 29 m.

Conclusions

Carbon was stabilised in the form of aromatic compounds in deep soil, whereas other carbon sources such as cellulose, chitin, and N-containing compounds were confined to the surface soil. LMWC (Z)-docos-13-enamide and bis(6-methylheptyl) phthalate, were the main components throughout the soil profiles representing 53–81% of the LMWC, and were a greater proportion of the organic matter at depths of 18–19 m.
Cardiovascular and cancer risk factors analysis for 2001–2020 from the global research output and European newspapers
Authors: Pallari Elena , Lewison Grant
Published: August 2022

Cancer and cardiovascular disease (CVD) are now two of the leading components of the global burden of disease, especially in high- and upper-middle-income countries. Causes of the diseases that are amenable to intervention are multiple: tobacco control closely followed by obesity treatment, including promotion of a healthy diet and physical exercise, remain the global priorities. We interrogated the Web of Science (WoS) from 2001 to 2020 to determine the numbers of papers describing research into 14 different possible risk factors causing the two diseases. These ranged in relative importance from tobacco and being overweight to the consumption of excessively hot drinks (linked to oesophageal cancer), pollution (linked to lung cancer particularly) and also non-interventional genetic risks. The risks varied between different continental regions, and obesity has increased as a risk factor for CVD in some of these regions. Because many of these factors are subject to human behavioural choices, we also investigated how such research was being presented to the European public through newspaper reportage. About 40% of the factors that influence the cancer burden can be attributed to particular causes, and more than 85% of those factors influencing CVD can also be so attributed. They are led by tobacco use as a risk factor for cancer, but this is slowly declining in most high-income settings. For CVD, the major risks are metabolic, such as high systolic blood pressure and high body-mass index, but also from tobacco use. Research outputs on some of these different factors in the continental regions correlated positively with their influence on the disease burdens. The selection of European newspaper stories was biased towards those risk factors that could be considered as being under the control of their readers. Reports of research in the mass media have an important role in the control of both cancer and CVD, and should be regarded by public health authorities as a useful means to promulgate health education. This paper is based on one presented at the ISSI conference in Leuven in July 2021 (Pallari and Lewison, in: Glänzel et al (eds) Proceedings of the 18th international conference on scientometrics and informetrics, 2021), but has been extended to cover CVD as well as cancer. The geographical analysis of risk factors and research publications has also been modified.
DnS: Distill-and-Select for Efficient and Accurate Video Indexing and Retrieval
Authors: Kordopatis-Zilos Giorgos , Tzelepis Christos , Papadopoulos Symeon , Kompatsiaris Ioannis , Patras Ioannis
Published: August 2022

In this paper, we address the problem of high performance and computationally efficient content-based video retrieval in large-scale datasets. Current methods typically propose either: (i) fine-grained approaches employing spatio-temporal representations and similarity calculations, achieving high performance at a high computational cost or (ii) coarse-grained approaches representing/indexing videos as global vectors, where the spatio-temporal structure is lost, providing low performance but also having low computational cost. In this work, we propose a Knowledge Distillation framework, called Distill-and-Select (DnS), that starting from a well-performing fine-grained Teacher Network learns: (a) Student Networks at different retrieval performance and computational efficiency trade-offs and (b) a Selector Network that at test time rapidly directs samples to the appropriate student to maintain both high retrieval performance and high computational efficiency. We train several students with different architectures and arrive at different trade-offs of performance and efficiency, i.e., speed and storage requirements, including fine-grained students that store/index videos using binary representations. Importantly, the proposed scheme allows Knowledge Distillation in large, unlabelled datasets—this leads to good students. We evaluate DnS on five public datasets on three different video retrieval tasks and demonstrate (a) that our students achieve state-of-the-art performance in several cases and (b) that the DnS framework provides an excellent trade-off between retrieval performance, computational speed, and storage space. In specific configurations, the proposed method achieves similar mAP with the teacher but is 20 times faster and requires 240 times less storage space. The collected dataset and implementation are publicly available: https://github.com/mever-team/distill-and-select.
Removal of Nitrogenous Compounds from Municipal Wastewater Using a Bacterial Consortium: an Opportunity for More Sustainable Water Treatments
Authors: Fontalvo Nubia Patricia Marquez , Gamero Wendy Beatriz Morgado , Ardila Henry Alfonso Maury , Gonzalez Andres Felipe Pulgar , Ramos Claudete Gindri , Muñoz Alexander Elias Parody
Published: August 2022

The integrated management of water resources is a requirement for environmental preservation and economic development, with the removal of nutrients being one of the main drawbacks. In this work, the efficiency of a bacterial consortium (Ecobacter WP) made up of eight bacterial strains of the genus Bacillus subtilis, Bacillus licheniformis, Bacillus megaterium, Bacillus cereus, Arthrobacter sp., Acinetobacter paraffineus, Corynebacterium sp., and Streptomyces globisporus was evaluated in the removal of nitrogen compounds in domestic wastewater in a plug flow system, in the extended aeration and bioaugmentation (FLAEBI). To promote the nitrification and denitrification processes, three doses were tested to establish the optimal concentration of the bacterial consortium on a laboratory scale and its subsequent application in an outdoor wastewater treatment plant (WWTP). The evaluation period was 15 days for each treatment in the laboratory and WWTP. The parameters monitored both at laboratory and outdoor were pH, temperature, dissolved oxygen, chemical oxygen demand (COD), biochemical oxygen demand (BOD5), ammonium, nitrites, and nitrates. The results indicated that the optimal concentration of the consortium was 30 mg L−1, with a removal of 92% of nitrate at the laboratory and 62% outdoor. Such a difference is attributed to the different operation residence times and the volume that caused different concentration gradients. The consortium studied can be used to promote nitrification and denitrification processes that intervene in the removal of nitrogenous compounds in plants with similar operating conditions, without investment in restructuring or design modification of the WWTP.

Graphical abstract
Organochlorine pesticide contamination in sediments from Richards Bay, South Africa: spatial trends and ecotoxicological risks
Authors: Mehlhorn Paul , Humphries Marc , Gensel Julia , Buah-Kwofie Archibold , Tyohemba Raymond Lubem , Haberzettl Torsten
Published: August 2022

The occurrence and distribution of organochlorine pesticides (OCPs) in aquatic systems is a matter of global concern and poses significant toxicological threats to both organisms and human health. Despite the extensive use of OCPs for pest and disease control in southern Africa, relatively few studies have examined the occurrence and toxicological risks of OCP residues in the region. This study investigates the composition, distribution, and potential sources of OCP contamination in sediments from Richards Bay, a rapidly developing industrial port on the northeast coast of South Africa. Surface sediments collected from Richards Bay Harbour and surrounding areas indicate that OCP contamination in the region is widespread. Total concentrations (∑OCP) in surface samples ranged from 135 to 1020 ng g−1, with hexachlorocyclohexanes (∑HCH; 35–230 ng g−1) and dichlorodiphenyltrichloroethanes (∑DDT; 12–350 ng g−1) the dominant contaminant groups detected. Metabolite isomeric compositions indicate that the presence of aldrin and endosulfan likely result from historical agricultural usage, while recent input of γ-HCH, heptachlor, and endrin may be linked to the illegal use of old pesticide stockpiles. Total DDT concentrations were dominated by p,p′-DDT (80 ± 64 ng g−1), which was attributed to its ongoing use in malaria vector control in the region. A210Pb-dated sediment core revealed that OCP input to the local environment increased dramatically from relatively low concentrations in the mid-1940s (∑OCP, 355 ng g−1) to peak levels (∑OCP, 781 ng g−1) in the 1980s/1990s. An overall decrease in ∑OCP concentration from the mid-2000s is likely related to restrictions on use following the Stockholm Convention in 2004. Despite current restrictions on use, OCP concentrations exceeded sediment quality guidelines in the vast majority of cases, raising concerns for protected estuarine and mangrove habitats in the area, as well as for local fishing and farming communities.
From the drama of unoccupied time and isolation due to Covid-19’s pandemic to the need for person-centered care at residential care facilities in Portugal
Authors: Barbosa Maria Miguel , Paúl Constança , Teixeira Laetitia , Yanguas Javier , Afonso Rosa Marina
Published: August 2022

During the pandemic, restrictive measures were implemented at Portuguese residential care facilities (PRCF), such as isolating residents and ceasing collective activities. It is important to understand how PRCF are implementing activities that allow residents to occupy their time and fight isolation. As such, we aim to analyze whether: 1. new activities were implemented for residents (identifying which were carried out); 2. occupation activities were provided to isolated residents in their rooms (identifying which were carried out); 3. the implementation of activities is associated with variables like the amount of staff. This is an exploratory, quantitative, and cross-sectional study. An online questionnaire was sent by email to 2325 PRCF and entities were asked to share it with their workers. The study was also divulged on social networks. Data collection occurred between July 8th and October 18th, 2020. The study had 784 staff members participating and 90.8% reported that new activities were implemented at their facilities, predominantly videocalls. Concerning isolated residents most respondents (64.4%) stated that providing activities was impossible. Results showed that those PRCF that expanded teams had a higher percentage of new activities and activities with residents isolated in bedrooms. These results are alarming because while residents should have had more resources to cope with the pandemic, higher risks of unoccupied time and isolation existed, a dramatic situation for its potentially harmful consequences. Focusing on sanitary issues (and less on older adults) may reinforce traditional care models that had shown negative impacts before the pandemic. This highlights the need to evolve the care paradigm during and beyond the pandemic at PRCF: with Person-Centered Care as an option.
How to Do Things with Information Online. A Conceptual Framework for Evaluating Social Networking Platforms as Epistemic Environments
Authors: Marin Lavinia
Published: August 2022

This paper proposes a conceptual framework for evaluating how social networking platforms fare as epistemic environments for human users. I begin by proposing a situated concept of epistemic agency as fundamental for evaluating epistemic environments. Next, I show that algorithmic personalisation of information makes social networking platforms problematic for users’ epistemic agency because these platforms do not allow users to adapt their behaviour sufficiently. Using the tracing principle inspired by the ethics of self-driving cars, I operationalise it here and identify three requirements that automated epistemic environments need to fulfil: (a) the users need to be afforded a range of skilled actions; (b) users need to be sensitive to the possibility to use their skills; (c) the habits built when adapting to the platform should not undermine the user’s pre-existing skills. I then argue that these requirements are almost impossible to fulfil all at the same time on current SN platforms; yet nevertheless, we need to pay attention to these whenever we evaluate an epistemic environment with automatic features. Finally, as an illustration, I show how Twitter, a popular social networking platform, will fare regarding these requirements.
Accepting Moral Responsibility for the Actions of Autonomous Weapons Systems—a Moral Gambit
Authors: Taddeo Mariarosaria , Blanchard Alexander
Published: August 2022

In this article, we focus on the attribution of moral responsibility for the actions of autonomous weapons systems (AWS). To do so, we suggest that the responsibility gap can be closed if human agents can take meaningful moral responsibility for the actions of AWS. This is a moral responsibility attributed to individuals in a justified and fair way and which is accepted by individuals as an assessment of their own moral character. We argue that, given the unpredictability of AWS, meaningful moral responsibly can only be discharged by human agents who are willing to take a moral gambit: they decide to design/develop/deploy AWS despite the uncertainty about the effects an AWS may produce, hoping that unintended and unwanted or unforeseen outcomes may never occurs, but also accepting to be held responsible if such outcomes will occur. We argue that, while a moral gambit is permissible for the use of non-lethal AWS, this is not the case for the actions of lethal autonomous weapon systems.
Enhanced ultrasonically assisted extraction of bitter melon (Momordica charantia) leaf phenolic compounds using choline chloride-acetic acid–based natural deep eutectic solvent: an optimization approach and in vitro digestion
Authors: Zannou Oscar , Pashazadeh Hojjat , Ghellam Mohamed , Ali Redha Ali , Koca Ilkay
Published: August 2022

Bitter melon (Momordica charantia) is a rich source of phytochemicals including phenolic compounds with diverse health-promoting benefits and potential food industry application due to their antioxidant potential. Bitter melon leaves have been limitedly investigated in comparison to bitter melon fruits. The current work explores the use of green extraction methodology to optimize enhanced extraction of phenolic compounds from bitter melon leaves using ultrasonically assisted extraction and choline chloride-acetic acid (CHAC)–based natural deep eutectic solvent. Extraction using CHAC significantly improved the extraction of total phenolic compounds, total flavonoids, and individual phenolic compounds (including gallic acid, chlorogenic acid, vanillic acid, epicatechin, and quercetin-3-glucoside) in comparison to water, ethanol, and methanol. The effect of molar ratio, water content, temperature, and time on the extraction efficiency of bitter melon leaf phenolic compounds by CHAC was explored and optimized with surface response methodology (central composite design). The optimum condition for the extraction of individual phenolic compounds is a molar ratio of 1:4.35 CHAC with 20.68% water content at 75 °C for 21.23 min. Evaluation of the bioaccessibility of individual phenolic compounds concluded that the most bioaccessible compound was vanillic acid (105.00 ± 2.52%) followed by salicylic acid, chlorogenic acid, syringic acid, gallic acid, epicatechin, and quercetin-3-glucoside.
Teachers and trainers in adult education–Investigating the dimensionality of their knowledge about methods and concepts of teaching and learning
Authors: Marx Christian , Goeze Annika , Kelava Augustin , Schrader Josef
Published: August 2022

Knowledge about methods and concepts of teaching and learning is considered an important aspect of the pedagogical-psychological knowledge (PPK) of teachers in adult and continuing education (ACE) for designing helpful situations of teaching and learning. The article poses the theoretical-conceptual and empirical question of the dimensionality of this knowledge using a sample ofN = 212 ACE teachers. The results point to the multidimensionality of this knowledge in the ACE field. The findings are critically discussed in terms of their robustness and scope, as well as possibilities for the further development of the test.
Design and Development of a Text-to-Speech Synthesizer for Afan Oromo
Authors: Chala Tamrat Delessa , Guta Ashenafi Chalchisa , Asebel Muluken Hussen
Published: August 2022

Speech is one of the natural ways of communication between humans, later extended as a means for human–computer interaction. It helps visually impaired people to read electronic texts and is used in information retrieval and language education. This paper proposed the development of a text-to-speech synthesizer for Afan Oromo (Oromo Language), using unit selection speech synthesizer approaches. Although several works have been conducted in the area of text-to-speech synthesis for technologically favored languages for many years, every language has its own unique features. So, speech synthesizer systems developed for one language cannot be used for another language, because the structures of one language are not presumably representative of others. It is clear that each program is based on the system corresponding to the phonetic rules of a certain language. Besides, the existing text-to-speech synthesizer for Afan Oromo was reviewed in this study and the result of developed prototype results are showing promising, however, still, their performance needs a lot of improvement in terms of intelligibility and naturalness using novel approaches and quality of corpus. Therefore, this research was initiated to develop the possibility of developing a prototype text-to-speech synthesizer to improve the performance of the text-to-speech synthesizer. In this study, Afan Oromo corpus was collected from genuine sources and prepared speech datasets both text and audio in collaboration with Afan Oromo experts. The performance of the synthesizer was tested by proper users for its intelligibility and naturalness using Mean Opinion Scale (MOS). The obtained result of naturalness of the prototype is 4.44 (very good) out of 5, which indicated that the result obtained is encouraging and better performance than the existing TTS of Afan Oromo in terms of intelligibility and naturalness. But the result scored in terms of intelligibility still needs further work. The main challenge is Afan Oromo has many dialects, so preparing a balanced text corpus from each dialect is very tough. Moreover, enhancement of the work is predicted to bring a reasonable level of intelligibility to the system.
Searching for a happily ever after: using fairy tales in primary classrooms to explore gender, subjectivity and the life-worlds of young people
Authors: Saxby Glenn
Published: August 2022

Fairy tales are ubiquitous in Australian primary schools. Drawing on a review of key literature, this paper aims to determine the implications of teaching fairy tales in the twenty-first-century primary classroom. Research points to the benefits of including fairy tales as a tool to improve all subject areas of the curriculum. Fairy tales present opportunities to positively engage students through the teaching of social justice and the development of emotional intelligence. The review of literature found that teachers need to be cautious and critical when teaching traditional fairy tales which often perpetrate an outdated, gender-ignorant representation of society, and allow students an opportunity to confront these ideas. The book form of Disney fairy tales can be problematic, particularly the earlier versions, which are criticised for being domesticated, sentimental and overly simplistic. The review has also found that multicultural fairy tales have enormous potential to increase cultural equity in the contemporary classroom, but unfortunately, they do not appear to be easily accessible in Australia. The fairy tale is constantly being reinvented and reimagined to fit into modern society, which has led to the emergence of the fractured fairy tale genre, where a traditional fairy tale is subverted. This review found that when used in a critical and inclusive manner, fairy tales have the potential to be an effective resource to teach primary school students in the contemporary classroom.
mvPPT: A Highly Efficient and Sensitive Pathogenicity Prediction Tool for Missense Variants
Authors: Tong Shi-Yuan , Fan Ke , Zhou Zai-Wei , Liu Lin-Yun , Zhang Shu-Qing , Fu Yinghui , Wang Guang-Zhong , Zhu Ying , Yu Yong-Chun
Published: August 2022

Next-generation sequencing technologies both boost the discovery of variants in the human genome and exacerbate the challenges of pathogenic variant identification. In this study, we developed Pathogenicity Prediction Tool for missense variants (mvPPT), a highly sensitive and accurate missense variant classifier based on gradient boosting. mvPPT adopts high-confidence training sets with a wide spectrum of variant profiles, and extracts three categories of features, including scores from existing prediction tools, frequencies (allele frequencies, amino acid frequencies, and genotype frequencies), and genomic context. Compared with established predictors, mvPPT achieves superior performance in all test sets, regardless of data source. In addition, our study also provides guidance for training set and feature selection strategies, as well as reveals highly relevant features, which may further provide biological insights into variant pathogenicity. mvPPT is freely available at http://www.mvppt.club/.
Identification of priority targets for intervention in outpatient antimicrobial stewardship
Authors: Arensman Hannan Kellie N. , Draper Evan W. , Uecker-Bezdicek Karen A. , Gomez-Urena Eric O. , Jensen Kelsey L.
Published: August 2022

A multimodal antimicrobial stewardship intervention was associated with a decrease in antibiotic prescribing for targeted non–coronavirus disease 2019 (COVID-19) upper respiratory infections from 27.6% in 2019 to 7.6% in 2021. We describe our approach to prioritizing departments for 3 levels of interventions in the setting of limited stewardship personnel.
Which glaciers are the largest in the world?
Authors: Windnagel Ann , Hock Regine , Maussion Fabien , Paul Frank , Rastner Philipp , Raup Bruce , Zemp Michael
Published: August 2022

Glacier monitoring has been internationally coordinated for more than 125 years. Despite this long history, there is no authoritative answer to the popular question: ‘Which glaciers are the largest in the world?’ Here, we present the first systematic assessment of this question and identify the largest glaciers in the world – distinct from the two ice sheets in Greenland and Antarctica but including the glaciers on the Antarctic Peninsula. We identify the largest glaciers in two domains: on each of the seven geographical continents and in the 19 first-order glacier regions defined by the Global Terrestrial Network for Glaciers. Ranking glaciers by area is non-trivial. It depends on how a glacier is defined and mapped and also requires differentiating between a glacier and a glacier complex, i.e. glaciers that meet at ice divides such as ice caps and icefields. It also depends on the availability of a homogenized global glacier inventory. Using separate rankings for glaciers and glacier complexes, we find that the largest glacier complexes have areas on the order of tens of thousands of square kilometers whereas the largest glaciers are several thousands of square kilometers. The world's largest glaciers and glacier complexes are located in the Antarctic, Arctic and Patagonia.
MERIP and Political Economy in Middle East Studies
Authors: Beinin Joel
Published: August 2022

The Middle East Research and Information Project (MERIP) was founded in 1971 as a project of the American New Left in solidarity with and drawing inspiration from the Beirut-centered Arab New Left and anti-imperialist struggles for national liberation in the Middle East and North Africa. The question of Palestine was a central, but certainly not exclusive, concern. From its origins MERIP was committed to political economy as a key method to understanding the Middle East and North Africa. It highlighted the importance of oil in the regional power structure and to the emergent U.S. empire. Many of its articles featured analyses of the social relationships of class and capital. MERIP was wary of “Arab socialism” and pan-Arab nationalism as official state ideologies. Its analysis of the 1979 Iranian revolution won MERIP and its emphasis on the importance of political economy a respected place in Anglo-American academia. Political economy never disappeared from MERIP's orientation, although its salience declined from the mid-1980s to the mid-2000s. The financial crisis of 2008 drew renewed attention to the structure of global capitalism. MERIP's history positioned it to participate in the renewed attention to class, capital, markets with more attention to the racialized and gendered character of these relationships.
Ecological systems theory and second language research
Authors: Chong Sin Wang , Isaacs Talia , McKinley Jim
Published: August 2022

“Context” has been increasingly featured and acknowledged in second language (L2) research because L2 teaching is recognised to be shaped by the environments in which it is situated. Numerous theoretical perspectives were introduced to L2 research that aim to capture the contextual forces at work in teaching and learning, including but not limited to Activity Theory, Complexity Theory, and Sociocultural Theory. Activity Theory holds that a learner's motives (human needs directed towards an object) are highly malleable, subject to the influence of such contextual variables as institutional rules, community, tools and artefacts available (see Leont'ev, 1978, 1981 who popularised Activity Theory from Sergei Rubenstein's founding and also Engeström's more current work in 1999). Complexity Theory, which has been widely adopted in both physical and social sciences, originates from physics (Martin et al., 2019). Complexity Theory was later introduced into L2 research by Diane Larsen-Freeman who posits that language learning is not only a process but a volatile and emerging system that is shaped by components of the system (e.g., learners, teachers, schools) engaging in constant and vibrant interactions (Larsen-Freeman, 2014). Sociocultural Theory highlights the sociocultural contexts where learning takes place (Lantolf, 2000; Vygotsky, 1978). Informed by a social constructivist view of learning, key concepts such as scaffolding (e.g., teachers’ support for learners) are put forward. In particular, Vygotsky argues that communication plays an indispensable role in language learning. Extrapolating Vygotsky's work to L2 research, Swain (2006) claims that languaging, dialogues among learners to discuss issues in L2 learning, is an important process of learning a L2.
Drivers of inflation convergence across countries: the role of standard gravity variables
Authors: Yilmazkuday Hakan
Published: August 2022

Using monthly headline inflation data covering 184 countries for the period between January 1971 and December 2020, this paper investigates the role of standard gravity variables on inflation convergence across country pairs. The convergence analysis by unit root tests is based on ten-year rolling windows to control for potential structural changes over time, whereas the corresponding results are connected to the standard gravity variables in the preceding year to investigate the drivers of inflation convergence and its speed. Regarding the existence of inflation convergence, empirical results show that having a common currency, a free trade agreement, proximity, a common border, or a colonial relationship between countries increases the probability of inflation convergence. Regarding the speed of inflation convergence, the very same gravity variables are shown to reduce the half-life of convergence. In both cases, the effects of having a common currency are shown to dominate those of other gravity variables.
Fair Use of Geographical Indications: Another Look at the Spirited Debate on the Level of Protection
Authors: Song Xinzhe , Wang Xiaoyan
Published: August 2022

One of the most contested issues in international trade negotiations is the level of protection granted to geographical indications (GIs). WTO Members are divided between the ‘Old World’ represented by the European Union and the ‘New World’ headed by the United States. For decades, conventional wisdom has suggested that the debate is indeed a disagreement over the terroir idea. This article tackles the debate from a largely unexplored perspective, namely, fair use exceptions, which allows us to find the opposite: even if countries embraced the terroir idea equally, the divide on protection level would persist because of divergent approaches to the fair use of GIs. This divergence derives from countries’ different preferences for balancing conflicting interests, different policy goals, and different understandings of what is ‘fair’. Other countries should take these considerations into account when choosing a protection level suitable for their national conditions and goals.
Emotion Perception Rules Abide by Cultural Display Rules
Authors: Ji Eunhee , Son Lisa K. , Kim Min-Shik
Published: August 2022

Abstract. The current study compared emotion perception in two cultures where display rules for emotion expression deviate. In Experiment 1, participants from America and Korea played a repeated prisoner’s dilemma game with a counterpart, who was, in actuality, a programmed defector. Emotion expressions were exchanged via emoticons at the end of every round. After winning more points by defecting, the counterpart sent either a matching emoticon (a joyful face) or a mismatching emoticon (a regretful face). The results showed that Americans in the matching condition were more likely to defect, or to punish, compared to those in the mismatching condition, suggesting that more weight was given to their counterpart’s joyful expression. This difference was smaller for Koreans, suggesting a higher disregard for the outward expression. In a second, supplementary experiment, we found that Korean participants were more likely to cooperate in the mismatching or regretful condition, when they thought their counterpart was a Westerner. Overall, our data suggest that emotion perception rules abide by the display rules of one’s culture but are also influenced by the counterpart’s culture.
Effects of Typhoon on Saltwater Intrusion in a High Discharge Estuary
Authors: Li Linjiang , Wang Chuning , Pareja‐Roman L. Fernando , Zhu Jianrong , Chant Robert J. , Wang Guihua
Published: August 2022

Saltwater intrusion in the Changjiang Estuary occurs in winter and dry season, which may affect drinking water supply in Shanghai. An atypical saltwater intrusion event, observed under high river discharge (>20,000 m3/s) in October 2018, coincided with the passage of super typhoon Kong‐rey. The response of the estuarine salt field is reproduced here with a numerical model for analysis with a Eulerian framework. Model results show that saltwater intrusion was mainly due to the landward advection of salt (∼260 t/s), which was driven by the storm surge (∼0.4 m) and landward Ekman transport under typhoon winds. The sheared salt flux (∼145 t/s) significantly contributes to the total landward flux, especially when the surge recedes after the typhoon has passed. Northwesterly winds increased vertical shear and stratification during the event. The maximum saltwater intrusion occurred about a day after the typhoon passage, and the salinity at the freshwater reservoir intake exceeds the local drinking standard of 0.45 psu. A numerical experiment shows that if Kong‐rey had passed during spring tide, the saltwater intrusion would have been weaker due to a stronger northward transport near the coast and a landward transport in the southern channels.
Differential Bank Migration Limits the Lifespan and Width of Braided Channel Threads
Authors: Chadwick A. J. , Steel E. , Passalacqua P. , Paola C.
Published: August 2022

Successful management of flooding and erosion hazards on floodplains depends on our ability to predict a river channel's shape and the lifespan during which it will continue to flow. Recent progress has improved our understanding of what sets the lifespan and width of single‐thread channels; the next challenge is to extend this knowledge to braided channels and their interwoven sub‐channels (threads). In this study, we investigate the lifespan and width of braided channel threads in a large experimental data set, coupled with particle‐image velocimetry‐derived measurements of riverbank erosion and accretion. We find that, unlike single‐thread channels, braided channels in the experiment do not exhibit an equilibrium between bank erosion and accretion. Instead, bank erosion outpaces lateral accretion, causing individual threads to widen and infill until they are abandoned. Thread lifespan is limited to the time it takes for threads to triple their width: tripling of the width yields enough bank material to aggrade more than half the channel depth, at which point flow is rerouted to a narrower thread. In consequence the width of active threads is limited to three times their initial width. Threshold channel theory accurately predicts the median thread width, which is roughly double the initial width and two‐thirds the limiting width. The results are consistent with existing field data and suggest that differential bank migration is sufficient to explain why braided channels show greater width variability and higher width‐to‐depth ratios than their single‐thread counterparts.
A Time Capsule from the Early Solar System Is En Route to Earth
Authors: Wolner C.
Published: August 2022

After an exciting encounter with asteroid Bennu, the OSIRIS-REx mission team looks forward to hitting pay dirt when a hefty sample of ancient planetesimal material is delivered to Earth next year.
Intensification of Very Wet Monsoon Seasons in India Under Global Warming
Authors: Katzenberger Anja , Levermann Anders , Schewe Jacob , Pongratz Julia
Published: August 2022

Rainfall‐intense summer monsoon seasons on the Indian subcontinent that are exceeding long‐term averages cause widespread floods and landslides. Here we show that the latest generation of coupled climate models robustly project an intensification of very rainfall‐intense seasons (June–September). Under the shared socioeconomic pathway SSP5‐8.5, very wet monsoon seasons as observed in only 5 years in the period 1965–2015 are projected to occur 8 times more often in 2050–2100 in the multi‐model average. Under SSP2‐4.5, these seasons become only a factor of 6 times more frequent, showing that even modest efforts to mitigate climate change can have a strong impact on the frequency of very strong rainfall seasons. Besides, we find that the increasing risk of extreme seasonal rainfall is accompanied by a shift from days with light rainfall to days with moderate or heavy rainfall. Additionally, the number of wet days is projected to increase.
Kobe earthquake: An urban disaster
Authors: Somerville Paul
Published: August 2022

The January 17,1995, Hyogo‐ken Nanbu earthquake was the most damaging to strike Japan since the great Kanto earthquake destroyed large areas of Tokyo and Yokohama and killed 143,000 people in 1923. As of January 30, the toll from the earthquake in Kobe and adjacent cities had reached 5,096 dead, 13 missing, and 26,797 injured. One‐fifth of the city's 1.5 million population was left homeless and more than 103,521 buildings were destroyed. The Hyogo

Prefectural Government estimated the cost of restoring basic functions to be about $100 billion dollars; the total losses including losses of privately owned property and reduction in business activity may be twice this amount, which would be 10 times higher than losses resulting from the 1994 Northridge, Calif., earthquake.