bluuebunny/crossref_metadata_2025 huggingface dataset:
PRESERVATION OF RESIDUAL ALVEOLAR RIDGE USING TOOTH SUPPORTED OVERDENTURE PROSTHESIS- A CASE REPORT
Authors:   Professor, Dept. of Prosthodontics, Govt. Dental College, Thiruvananthapuram, Kerala, India., Ravichandran R. , Kumar Devendra ,   Junior Resident, Dept. of Prosthodontics, Govt. DentalCollege, Thiruvananthapuram, Kerala, India., Kumar K. Harsha ,   Professor and head, Dept. of Prosthodontics, Govt. DentalCollege, Thiruvananthapuram, Kerala, India., V. Nair Vivek ,   Professor, Dept. of Prosthodontics, Govt. Dental College, Thiruvananthapuram, Kerala, India.
Published: June 2022

Loss of alveolar bone is a great entity to be worried about after loss of natural teeth. Overdenture is a treatment modality in means of alveolar bone preservation retention and stability of prosthesis by preserving the roots of the remaining teeth thereby increase the patients perception, acceptance and quality of life. It is the most commonly treatment modality for elderly patient with two or more teeth remaining in the either arch. The use of copings and precision attachments on the remaining teeth enhances the retention of the denture. Dentists have a responsibility to prevent tooth loss whenever possible and everything should be done to keep the patient away from an edentulous state. Preventive prosthodontics emphasizes upon the importance of procedures that can delay or rectify the future problems in prosthesis and the overdentures are the optimum method to achieve this requirement. In this present case report described the rehabilitation of a patient with few natural teeth present using tooth supported overdenture which restored the function and evades the social stigma, thereby improving the quality of life of the patient.
MANAGEMENT OF STAGE III PERIODONTITIS: AN INTERDISCIPLINARY APPROACH
Authors:   King Georges Medical University, Lucknow AashirwadEncl, IP Extn, New Delhi 110092, India., Shah Anshdha , Sahney Tanu ,   Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Himalaya Encl, Vrindavan Yojna, Lucknow 226301, India., Yadav Shivam ,   Autonomous State Medical College, Hardoi, HimalayaEncl, Vrindavan Yojna, Lucknow 226301, India.
Published: June 2022

Periodontitis is a chronic inflammatory disease with varied symptoms that may be bleeding gums, malodour, tooth mobility or irritation and inflammation of the gingiva. Signs of severe periodontitis include tooth loss, masticatory dysfunction, negative effects on aesthetics and function. Depending upon the severity of the symptoms the treatment varies from case to case. This case report describes the management of a Stage III periodontitis in a 23 years old female patient, who was concerned by the impact of pathological migration on aesthetics. Treatment planning was done with focus on management of the pathology keeping in mind the concerns presented by the patient. The primary treatment was focused on management of periodontitis by removal of local factors and antimicrobial therapy to prevent further destruction of periodontal tissues. The prosthetic phase was planned to address the aesthetic concerns of the patient.Hence, an interdisciplinary approach was used to restore function and aesthetics.
ANALYSIS OF DETERMINANTS OF BOOK-TAX DIFFERENCES: EVIDENCE FROM FRENCH LISTED COMPANIES
Authors:   Laboratory L.R.GFC, Faculty of Economic Sciences and Management, University of Sfax-Tunisia., Bougacha Fatma , Khoufi Walid ,   Laboratory L.R.GFC, Faculty of Economic Sciences and Management, University of Sfax-Tunisia.
Published: June 2022

The key objective of our research paper consists of consulting the set of explicative factors relative to book-tax differences within the French context especially after the mandatory adoption of international accounting standards, IAS/IFRS, by listed companies. Attributing several regulatory and empirical arguments in a special framework, the focus was on factors linked with non-discretionary (or regulatory) book-tax differences (goodwill and other intangibles assets, income or loss associated to the equity method as well as to the minority interest and deferred tax) and factors linked with discretionary book-tax differences (earnings management and/or tax management). Considering a panel of 1120 observations, the analysis of regression showed that tax management through downward earning management apprehended by discretionary accruals positively affects discretionary book-tax differences. Besides, tax management practices combined with earnings management via institutional ownership negatively affected discretionary differences. Moreover, the tax management policy practiced by companies measured by the effective tax rate reduced the level of discretionary book-tax differences. The current study shed light on whether various factors could affect book-tax differences via a multi-theory framework. Indeed, book-tax differences play a remarkable role in informing not only fiscal authorities but also external investors in the real financial situation of the company. To my mind, this study represented the first analysis aiming to explore determinants of book-tax differences in the French context particularly in the consolidated accounts of listed companies.
CASE REPORT: SPONTANEOUS HEMOTHORAX- A RARE PRESENTATION OF ECTOPIC PREGNANCY
Authors:   Senior Resident, Department of Obstetrics and Gynecology, Mahatma Gandhi Hospital, Jaipur., Agrawal Nidhi , Tiwari Kalpana ,   Associate Professor and unit head, Department of Obstetrics and Gynecology, Mahatma Gandhi Hospital, Jaipur., Bansal Charul ,   Junior Resident, Department of Obstetrics and Gynecology, Mahatma Gandhi Hospital, Jaipur.
Published: June 2022

Common presenting symptoms of an ectopic pregnancy are pain abdomen, amenorrhea, vaginal bleeding and syncope some times. Although it is typically confined to pelvis, rare manifestations involving the thorax, abdomen or pericardium have been documented(3-6). We are reporting a case of ruptured ectopic pregnancy presenting mainly as hemothorax. A 27 Years old female patient P2L2A2, Previous 2 LSCS not tubal ligated with history of oligomenorrhea, initially complained of pain abdomen, vomiting and syncopal attack for which she received some pain killer and IV fluids at some local hospital. Over next 3 to 4 days, she complained of increasing breathlessness and cough. Her chest X- RAY (figure- 1) and chest CECT was done that showed right side massive pleural effusion with collapse of right lung and left side shift of trachea and mediastinum. In view of these findings ICT was inserted that drained 2 liters of dark hemorrhagic fluid. CECT abdomen showed an irregular mildly enhancing, solid, cystic lesion of size 7.5X 4.8X 5.6 cm in right adnexal region with mild to moderate fluid collection in peritoneal cavity. UPT was positive, Serum beta HCG was 1286 m IU/ml. Laparotomy was done in view of ruptured ectopic pregnancy with hemoperitoneum with associated hemothorax. Intraoperatively approx. 1500cc hemoperitoneum (Figure-4) found. In postop period ICT Drain fluid changed to serous and drained only 150cc in next 24 hrs (Figure-5). This is a rare case of spontaneous hemothorax precipitated by hemoperitoneum secondary to ruptured tubal ectopic pregnancy. There have been few case reports of hemothorax associated with ectopic pregnancy in literature.
HERBAL REMEDIAL PRACTICES FOR VIRAL DISEASES AMONG INDIGENOUS PEOPLE OF TINSUKIA DISTRICT OF UPPER ASSAM (INDIA)
Authors:   Department of Botany, Digboi College, Digboi, Tinsukia, Assam,India,786171., Dutta T.C. , Das S.M. ,   Department of Biology, Guru Teg Bahadur Academy, Tinsukia, Assam, India, 786126., Choudhury R.S. ,   Veterinary Consultant, Tinsukia, Assam, India, 786125., Saikia A.J ,   Consultant Surgeon, Tinsukia, Assam, India, 786125.
Published: June 2022

Among infectious diseases, particularly viral infections sometimes become epidemic leading cause of death of man and animals. To prevent, cure and treatment of commonly occurring viral infections, indigenous rural population of Tinsukia district rely on traditional medicinal practitioners who have not only the knowledge of plants but also have the knowledge of disease diagnosis based on symptoms. They have been using phytoconstituents of the plant parts like leaves, roots, stem, barks, fruits, flowers, seeds, and animal products as medicines traditionally for the treatment of various viral diseases. In this study an attempt has been made to assess the traditional practices for common viral diseases of human and domestic animals among indigenous communities of Tinsukia district of Upper Assam. Forty different species of plants procured from the district identified which have been using traditionally as herbal medicine to treat eleven viral diseases of human and domestic animals. Further study in this field will uncover the traditional knowledge of herbal remedies for viral infections.
ADAPTATION TO NEW EDUCATION SYSTEM DUE TO THE COVID-19 PANDEMIC
Authors:   Assistant Professor,Department of Psychology, Muralidhar Girls College, Kolkata, India., Basak Rituparna
Published: June 2022

In the educational field, the Covid-19 pandemic caused students academic careers to come to a halt.Governments around the world, including Indias, declared a state of emergency lockdown to prevent disease contamination and enforce social isolation.In a press release(March 21, 2020), the Ministry of Human Resource Development (MHRDa) of the Government of India shared numerous free digital e-learning platforms, taking into account the future of students.Despite having many negative consequences around the world, the unexpected Covid-19 outbreak forced the entire world to switch to a new digital system. This provided a chance for Indias education system to change from a traditional to a digital model.Teachers and students both play an important part in successfully executing teaching and learning in a digital classroom, bridging the gap between traditional and virtual systems by adapting the essential technologies.During the lockdown, teachers, students, and parents were confronted with the unforeseen position of having to integrate the ICT curriculum to run the system successfully.
GRANULOSA TUMORS: ABOUT 10 CASES
Authors:   Department of Obstetrics and Gynecology Mohammed VI Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First University., Anass Mettahri , Jaber Tricha ,   Department of Obstetrics and Gynecology Mohammed VI Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First University., Taheri Hafsa ,   Department of Obstetrics and Gynecology Mohammed VI Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First University., Hanane Saadi ,   Department of Obstetrics and Gynecology Mohammed VI Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First University., Ahmed Mimouni ,   Department of Obstetrics and Gynecology Mohammed VI Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First University.
Published: June 2022

Granulosa tumors arise from the mesenchyme and sex cords of the ovary. They are quite rare. Theyrepresent 0.6 to 3% of all ovarian tumors and 5% of ovarian malignancies. They are the mostfrequent tumors of the sexual cords and stroma. The purpose of our study:To describe the epidemiological, anatomical-clinical and evolutionary characteristics of granulosatumors and to study the different prognostic factors. Materials and methods:Our retrospective study covers 10 cases of ovarian granulosa tumor diagnosed at the gynecologyobstetrics department of the CHU Mohammed VI of Oujda. Over a period of 5 years, from September2016 to September 2021. Results:- The average age of onset of the adult form is 58.4 years (35-38-52-57-66-81). And that of theoccurrence of the juvenile form, is 18.6 years (18-19-22-31).Clinical signs were mainly dominated by abdominal distension, chronic abdominal-pelvic pain andmetrorrhagia.All patients had clinically palpable pelvic tumors.Suprapubic pelvic ultrasound was performed in all our patients.It allowed to link the pelvic mass to its adnexal origin, with an average size, 141.5mm, variablebetween 63mm and 220mm. The CT scan was performed in all our patients. It allowed us to determine the size of the masses andtheir relationship with the surrounding structures.The histological study concluded in a granulosa tumor adult type in 60% of the cases and in agranulosa tumor juvenile type in 40% of the cases.80% of patients received conservative treatment, 20% received radical treatment.60% of our patients have received chemotherapy.No patient had radiotherapy. One patient had a recurrence and all patients are still alive after surgical treatment. Conclusion: Granulosa tumors are rare, of the group of tumors of the sexual cords and the ovarian stroma. The adult forms are of slow evolution, often diagnosed at an early stage are potentially malignant tumors, the recurrences often very late (10-20 years) their treatment is based essentially on surgery more or less chemotherapy. Juvenile forms, rare (5%) with good prognosis. Prolonged post-therapy follow-up is necessary because of late recurrences for Adult forms, frequent and early for juvenile forms.
ENDOMETRIAL TUBERCULOSIS REVEALED BY POST-MENOPAUSAL METRORRHAGIA REPORT CASE
Authors:   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First UniversityOujda, Morocco., Anass Mettahri , Ousti Amina ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First UniversityOujda, Morocco., Hafsa Taheri ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First UniversityOujda, Morocco., Hanane Saadi ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First UniversityOujda, Morocco., Ahmed Mimouni ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Faculty of medicine and pharmacy of Oujda Mohammed First UniversityOujda, Morocco.
Published: June 2022

Because genital tuberculosis is frequently asymptomatic, the disease may not manifest itself for years after the initial infection. Clinical symptoms usually appear 10 to 15 years after the initial infection. We report a case of 47 years old women with a history of right breast cancer who was suffering from post menauposicmetrorrhagia, ultrasound revealed thickening of the endometrium, and the biopsy revealed endometrial tuberculosis, Genital tuberculosis is uncommon in postmenopausal women and accounts for 1% of postmenopausal metrorrhagia. In 60-70 percent of cases, the endometrium is affected. It is difficult to explain the diseases low prevalence in this age group. The majority of authors believe that the endometrial atrophy and decreased vascularity associated with this hypoestrogenic phase provide an unfavorable environment for Mycobacterium growth. The standard treatment regimen is currently well codified and is based on daily administration of Isoniazid and Rifampicin for 6 months, followed by Pyrazinamide and Ethambutol for the first 2 months. Throughout the treatment, clinical and paraclinical monitoring is performed on a regular basis.
UN CAS RARE DE CARCINOME MAMMAIRE : LE CARCINOME NEUROENDOCRINE DU SEIN
Authors:   Service de Gynecologie Obstetrique, CHU Med VI, Marrakech, Maroc., El Idrissi Soukaina , Asmouki Hamid ,   Service de Gynecologie Obstetrique, CHU Med VI, Marrakech, Maroc., Sidiki Sidibe Aboubacar ,   Service de Gynecologie Obstetrique, CHU Med VI, Marrakech, Maroc., Karam Harou ,   Service de Gynecologie Obstetrique, CHU Med VI, Marrakech, Maroc., Aboulfallah Abderrahim ,   Service de Gynecologie Obstetrique, CHU Med VI, Marrakech, Maroc., Soummani Abderaouf ,   Service de Gynecologie Obstetrique, CHU Med VI, Marrakech, Maroc.
Published: June 2022

Les cancers du sein de type neuroendocrine sont des tumeurs rares et actuellement peu connues. Leur incidence varie de moins de 1 % a 5 % des cancers du sein. Le diagnostic est confirme par lexpression des marqueurs neuroendocrinespar plus de 50% des cellules tumorales. Nous decrivons un cas de carcinome neuroendocrineprimitif du sein, et a la lumiÃ¨re de la litterature, nous detaillerons les aspectsepidemiologiques, diagnostiques et therapeutiques de cette entite histologique.
ACUTE COLONIC PSEUDO-OBSTRUCTION IN SICKLE CELL DISEASE: A CASE REPORT
Authors:   MBSS, Pediatric Department Ahmed GasimHospital, Khartoum, Sudan., Ahmed Anas , Mahmoud Wogdan ,   Pediatricconsultant M.D SMSB Ahmed GasimHospital, Khartoum, Sudan., Abdeen Omyma ,   General Surgery Specialist M.D SMSB, BahriTeaching Hospital, Khartoum, Sudan.
Published: June 2022

Acute colonic pseudo-obstruction is a rare yet an important complication of sickle cell disease to be known as lack of knowledge about it may lead to unnecessary surgical interventions due to its similar presentation of other acute surgical conditions. Here I present a 15 years old boy who has newly discovered to have sickle cell disease presented with pseudo intestinal obstruction and was successfully treated with a combination plan of intestinal obstruction and sickle cell disease.
SOK: IS IPHONE ACTUALLY SECURE?
Authors: Kumar Paul Sanjeev
Published: June 2022

iOS is considered a secure operating system that considers privacy as a primary feature for the user. This review is intended to find is it true and can it be sufficient to persuade hardcore Android users.
NOVEL MUTATION IN THE CYP11B2 GENE IN AN INFANT WITH CONGENITAL HYPOALDOSTERONISM
Authors:   SR Pediatrics Department, HH, DHA, UAE., A. Mukhtar Eyas , Al Hussain Mahmoud ,   Consultant Pediatrics Department, HH, DHA, UAE., A.M Rahama Khalid ,   SSR Pediatrics Department, HH, DHA, UAE., M. Abdalla Ashraf ,   SR General Surgeon, HH, DHA, UAE.
Published: June 2022

We report a 4-monthboy infant withisolated congenital hypoaldosteronism due to a novel mutation in CYP11B2 gene who presented with, failure to thrive, profound hyponatremia, hyperkalemia and mild metabolic acidosis, which managed byintravenous saline, oral saline, resoniumandcaloriesformula. In infants with severe electrolyte disturbance,it is important to rule out CAH and consider other rare form of isolated hypoaldosteronism and pseudohypoaldosteronism, since prompt and appropriate treatment will correct the associated electrolytes abnormalities.
QUALITY OF LIFE AMONG PHYSICIANS IN RESIDENCY PROGRAMS IN AL MADINAH 2022
Authors: A. Arr Mohammed , F. ALAhmadi Ahmed , A. Al-Harbi Mohammed , G. Al ghamdi Abdulwahab , A. Rahman Al-Dubai Sami
Published: June 2022

Objective:The aim of this study is to determine the quality of life and associated factors of physicians in residency training programmes in Al Madinah city. Methods:A cross-sectional study was conducted in three training centres including four main specialities (family medicine, paediatric, internal medicine and surgery) in Al-Madinah, Saudi Arabia. A self-administered questionnaire was used that included socio-demographic and occupational characteristics, and the short version of Arabic World Health Organization quality of life questionnaire (WHOQOL-BREF). Appropriate statistical analysis were used, including t-test, analysis of variance (ANOVA) test, and multiple linear regression models. Results:The highest mean score was in the environmental domain, followed by physical, social, and mental health finally, with score of 75.6%, 53.1%, 50.8%, and 49.2% respectively. The mean score of overall QOL and health satisfaction was 54.1%. In multiple linear regression analysis, gender was a significant predictor for overall QOL, overall health satisfaction (P<0.001), psychological (P<0.001), physical (P<0.001), and environmental domains (P= 0.014). Physicians without chronic disease had better overall QOL, and psychological score compared to physicians with chronic disease (P= 0.038, P= 0.032, respectively) Married physicians had better social health (P= 0.010) and obese physicians had poorer QOL and overall health satisfaction (P<0.001). Conclusion:This study found that male physicians, compared to females, had better QOL in the four domains of health. Obese physicians had poorer overall quality of life and health satisfaction relative to non-obese physicians. Physicians without chronic disease had better overall QOL, and psychological score compared to physicians with chronic disease. Married physicians had better social score.
A FIRST LONGITUDINAL GROWTH STUDY OF STATURE AND WEIGHT OF THE SCHOOL CHILDREN FROM JESSORE DISTRICT IN BANGLADESH
Authors:   PhD Fellow, Department of Statistics, University of Rajshahi, Rajshahi 6205 and Assistant Professor, JessoreShikkha Board Govt. Model School and College, Jessore, Bangladesh., Ali Nawaz Md. Shahjada , Abu Shahin Md. ,   Lecturer, AgraniSchool &College, RUET, RUET Campus, Rajshahi 6204., Abdul Khalek Md. ,   Professor, Department of Statistics, University of Rajshahi, Rajshahi 6205., Ayub Ali Md. ,   Professor, Department of Statistics, University of Rajshahi, Rajshahi 6205.
Published: June 2022

Objective: The purpose of this study was to measure longitudinal Anthropometric data in the age interval 6-18 years of the school children of Jessore District in Bangladesh. Materials: Primary dataon stature and weight were collected longitudinally from 2006 to2018 using two stage random sampling technique. Methods:Descriptive statistics and their simulated valuesonstature, weight and BMI were calculated. Quantile regression was considered to the longitudinal data to develop growth charts. Results: The population mean weight (kg) for boys at the age 8 (year) were condensed in 22.20Â±0.38 whereas for girls that were more condensed in the range 23.06Â±0.58. While, for boys, at the age 18 year this mean were in 58.80Â±1.26 little bit fluctuated compared to that in other ages but a little bit scattered range was found for girls at the age 18 year as 53.56Â±1.54.The stature for age implied that for boys it was smoothly increasing while for girls it was smoothly increasing until age 12.5 but after that age it was increasing with slow motion and also motion with ups and down. The Weight for age shows that the upper 25% of the heavier children continued their strictly increasing patterns both in their stature and weight. About 42% boys and 33% girls showed always underweight in the age range 7-18 years. Only 2% girls and 1% boys showed overweight after age 12. Conclusion: These results and several growth charts might be used by the medical practitioners as well as the growth scientists.
Basic influent sewage quality reflects sewershed characteristics in Tokyo city
Authors: Guo Zhongyu , Hatakeyama Takayuki , Yoshimura Chihiro , Wang Tingting , Hatano Yuta
Published: June 2022

Sewage comprises multifarious information on sewershed characteristics. For instance, influent sewage quality parameters (ISQPs) (e.g., total nitrogen (TN)) are being monitored regularly at all treatment plants. However, the relationship between ISQPs and sewershed characteristics is rarely investigated. Therefore, this study statistically investigated relationships between ISQPs and sewershed characteristics, covering demographic, social, and economic properties in Tokyo city as an example of a megacity. To this end, we collected ISQPs and sewershed characteristic data from 2015 to 2020 in 10 sewersheds in Tokyo city. By principal component analysis, spatial variability of ISQPs was aggregated into two principal components (89.8% contribution in total), indicating organics/nutrients and inorganic salts, respectively. Concentrations of organics/nutrients were significantly correlated with the population in sewersheds (daytime population density, family size, age distribution, etc.). Inorganic salts are significantly correlated with land cover ratios. Finally, a multiple regression model was developed for estimating the concentration of TN based on sewershed characteristics (R2=0.97). Scenario analysis using the regression model revealed that possible population movements in response to the coronavirus pandemic would substantially reduce the concentration of TN. These results indicate close relationships between ISQPs and sewershed characteristics and the potential applicability of big data of ISQPs to estimate sewershed characteristics and vice versa.
Determinants of bather hygiene in public swimming pools: a mixed-methods analysis of online discussion comments
Authors: Young Ian , Robillard Paige , Loeffler Pauline , Sekercioglu Fatih
Published: June 2022

Swimming in public pools can expose bathers to microbiological (e.g., Cryptosporidium) and chemical (e.g., disinfection by-product) hazards, which can lead to recreational water illness. Adequate hygienic behaviours among bathers are important to reduce these risks. However, prior studies have found low compliance with pre-swim showering and avoidance of urinating in pools. We conducted a mixed-methods analysis of online discussion comments to identify key determinants of these two behaviours. We identified relevant discussion threads on Reddit, Quora, and swimming forums. Identified comments were classified as having a positive or negative sentiment towards the behaviour, and they were thematically analyzed according to the Theoretical Domains Framework (TDF). We analyzed 986 comments from 45 threads; 49.8% of comments were classified as expressing a positive sentiment towards the behaviour. Positive sentiments were more commonly expressed towards pre-swim showering compared to avoidance of urinating in pools (60.1 vs. 47.1%). Eleven themes were identified across the following eight TDF domains: beliefs about consequences (n = 362 comments), social influences (n = 298), beliefs about capabilities (n = 240), social/professional role and identity (n = 144), knowledge (n = 138), emotions (n = 137), reinforcement (n = 78), and environmental context and resources (n = 33). Results can help to inform targeted educational and outreach strategies with bathers to encourage increased adoption of hygienic behaviours.
Carbapenemase-producing Aeromonas species isolated from the urban-impacted Akaki river in Ethiopia
Authors: Yitayew Berhanu , Woldeamanuel Yimtubezinash , Asrat Daniel , Aseffa Abraham , Olsson Per-Erik , Mihret Adane , Jass Jana
Published: June 2022

Carbapenemase-producing Aeromonas species are an emerging health threat. This study aimed to determine carbapenemase-mediated resistance among Aeromonas isolates from the Akaki river, Ethiopia during the dry and wet seasons in 2019–2020. Antimicrobial susceptibility to carbapenems and cephalosporins was determined and carbapenemase production was confirmed. Of 163 isolates, the majority were human pathogens Aeromonas caviae (62), Aeromonas hydrophila (33) and Aeromonas veronii (49). These isolates were resistant to carbapenem and cephalosporin antibiotics, with the highest resistance to cefotaxime 86 (59.7%), ertapenem 71 (49.3%) and imipenem 65 (45.1%). Resistance to carbapenem antibiotics varied between species, where most A. veronii 37 (75.5%) and A. hydrophila 28 (84.8%) were resistant to imipenem and all A.caviae were sensitive. A. veronii, A. caviae and A. hydrophila resistance to meropenem was 31 (63.3%), 3 (4.8%) and 19 (57.6%), respectively. Of isolates resistant to carbapenem, 82.1% A. hydrophila and 94.4% A. veronii were carbapenemase producers. Cephalosporin resistance also varied among the different species. The highest resistance to carbapenem antibiotics was in isolates collected during the wet season (p<0.05); however, it was not consistent across all classes of antibiotics tested. The rivers in megacities could be reservoirs of carbapenemase-producing Aeromonas spp.
Risk assessment of non-point source pollution in karst reservoirs based on ‘source–sink’ landscape theory
Authors: Zhao Weiquan , Zhou Zhongfa , Zhao Zulun , Li Wei , Li Qiuhua
Published: June 2022

The quantitative identification of areas at risk for such pollution is conducive to allocating limited government funds to critical areas and the efficient and economical management of water environments. Here, the Baihua Lake watershed, an important drinking water source for Guiyang City, was taken as the study area. The location-weighted landscape contrast index (LCI) and non-point source pollution risk index (NSPRI) were developed based on the ‘source–sink’ landscape theory. The method takes into account the risk of pollution source formation and pollutant transport. A total of 348 natural sub-watersheds were used as assessment units by estimating the nitrogen and phosphorus pollution emission (absorption) potentials of different landscape types in the sub-watersheds and considering the influence of vegetation cover, distance from the reservoir, and slope in the transmission process, a quantitative assessment of Baihua Lake's pollution was carried out; the reliability of the method was verified by comparing the assessment results with measured water quality data and field surveys. The results indicate (1) 132 sub-watersheds (37.93%) dominated by source effects, mainly distributed in Yanshanhong Township, Yeya Township, and the Qinglong Subdistrict, with construction land and farmland as the main landscape types, and 216 sub-watersheds (62.07%) dominated by sink effects, mainly distributed in Zhanjie and Baihuahu Townships, with forests as the primary landscape type. (2) Additionally, 17 sub-watersheds (4.89%) show extremely high risk for non-point source pollution; these watersheds are mainly distributed in the Qinglong Subdistrict and mainly consist of urban residential areas and schools. These sub-watersheds discharge a large volume of sewage, which threatens the water quality of the upper reaches of Baihua Lake and must be managed. (3) The rivers corresponding to relatively high-risk, high-risk, and extremely high-risk sub-watersheds include the Dongmenqiao, Limu, Changchong, and Maixi Rivers.
The water audit mode of water environment and water ecology based on evaporation in industrial parks
Authors: Zhang X. L. , He W. T. , Li L. Y. , Wang Y. R. , Li X. J. , Li X. , Li H. Y.
Published: June 2022

With large-scale industrial parks developing, concern regarding high evaporation and its spillover impacts on water environment and water ecology has grown significantly in recent years. However, it is hard for the traditional water audit to meet the needs of the collaborative management of water environment and water ecology based on evaporation (3E), which requires a multi-dimensional evaluation. The purpose of this paper is to accurately evaluate industrial parks' impact considering the water life-cycle. This paper proposes a systematic 3E water audit method that contains a logical framework and a comprehensive evaluation index system with five dimensions and 25 indexes, then applies it to a typical iron and steel industrial park in China. The results presented the 3E audit score of the Chengsteel IP as 89.91, suggesting comprehensive performance is good. The score and grade of every index, especially the quantity of water evaporation per ton of steel, were provided. This paper indicates that the new method developed can systematically evaluate the impact of industrial parks. In addition, our analysis highlights the different management strategies and practices that relieve the impacts of the whole water-use process on legal, eco-environmental, economic, social, and technical dimensions.
Enhancement of E-Peroxone process with waste-tire carbon composite cathode for tinidazole degradation
Authors: Xu Anlin , Liu Wanqun , Chu Leping , Zhang Yunhai , He Yide , Zhang Yongjun
Published: June 2022

The cathode is the key component in the electro-peroxone process (E-Peroxone), which is popularly constructed with carbon materials. This study developed an innovative method to fabricate a cathode with waste-tire carbon (WTC) whose performance was evaluated for the degradation of tinidazole (TNZ), an antibiotic frequently detected in water. It was found that the addition of WTC in the cathode can significantly promote the yield of H2O2 and the current efficiency: around 2.7 times that of commercial carbon black at the same loading. The critical influencing factors were studied, including the current density, ozone concentration, initial pH value, chlorine ions and initial TNZ concentration. The scavenger tests demonstrated the possible involvement of •OH and . Some transformation products of TNZ were identified with UPLC-MS and the degradation pathway was proposed accordingly. These results demonstrated the potential of WTC for developing E-Peroxone cathodes.
Desafios da assistência de enfermagem em cuidados paliativos: revisão integrativa
Authors: Sanches Couto Daniela , Lemes Farias Rodrigues Kaique Saimom
Published: June 2022

Objetivo: levantar os desafios que a enfermagem encontra para desempenhar a assistência aos pacientes em Cuidados Paliativos, a partir da produção cientifica disseminada em periódicos on-line. Método: revisão integrativa da literatura, com coleta de dados no mês de maio de 2018, nas bases de dados Banco de Dados em Enfermagem, Literatura Latino-Americana e do Caribe em Ciências da Saúde e Scientific Electronic Library Online. Resultados: foram identificadas 35 publicações, cujas análises textuais permitiram a construção de quatro abordagens temáticas: Educação em enfermagem; Assistência/cuidado em enfermagem; Implementação de diretrizes. Conclusão: o estudo verificou as lacunas da assistência de enfermagem em cuidados paliativos, levantando a necessidade do desenvolvimento de novos estudos para disseminar conhecimento sobre a temática.Descritores: Cuidados paliativos; Enfermagem; Cuidados paliativos na terminalidade da vida; Cuidados de enfermagem.CHALLENGES OF NURSING CARE IN PALLIATIVE CAREObjective: To raise the challenges that nursing encounters to perform assistance to patients in Palliative Care, based on scientific production disseminated in online journals. Methods: Integrative literature review, with data collection in the month of May 2018, in the databases Database in Nursing, Latin American and Caribbean Literature in Health Sciences and Scientific Electronic Library Online. Results: 35 publications were identified, whose textual analysis allowed the construction of four thematic approaches: Education in nursing; Nursing assistance / care; Implementation of guidelines. Conclusion: the study verified the gaps in nursing care in palliative care, raising the need for the development of new studies to disseminate knowledge on the subject.Keywords: Paliative care; Nursing; Hospice care; Nursing care.DESAFÍOS DE LA ATENCIÓN DE ENFERMERÍA EN LA ATENCIÓN PALIATIVAObjetivo: Plantear los desafíos que enfrenta la enfermería para brindar asistencia a los pacientes en Cuidados Paliativos, con base en la producción científica difundida en revistas en línea. Métodos: Revisión bibliográfica integradora, con recopilación de datos en mayo de 2018, en las bases de datos de la base de datos en enfermería, literatura latinoamericana y caribeña en ciencias de la salud y biblioteca electrónica científica en línea. Resultados: Se identificaron 35 publicaciones, cuyo análisis textual permitió la construcción de cuatro enfoques temáticos: Educación en enfermería; Asistencia / cuidado de enfermería; Implementación de lineamientos. Conclusión: El estudio verificó las brechas en la atención de enfermería en los cuidados paliativos, lo que plantea la necesidad de desarrollar nuevos estudios para difundir el conocimiento sobre el tema.Descriptores: Cuidados paliativos; Enfermería; Cuidados paliativos al final de la vida; Atencíon de enfermería.
Long Non-coding RNAs: Pivotal Epigenetic Regulators in Diabetic Retinopathy
Authors: Chen Peng , Song Zhaoxia , He Chang , Wen Jianping , Yang Jianli
Published: June 2022

Diabetic retinopathy (DR) is a severe complication of diabetes; however, its mechanism is
not fully understood. Evidence has recently revealed that long non-coding RNAs (lncRNAs) are abnormally
expressed in DR, and lncRNAs may function as pivotal regulators. LncRNAs are able to
modulate gene expression at the epigenetic level by acting as scaffolds of histone modification complexes
and sponges of binding with microRNAs (miRNAs). LncRNAs are believed to be important
epigenetic regulators, which may become beneficial in the diagnosis and therapy of DR. However, the
mechanisms of lncRNAs in DR are still unclear. In this review, we summarize the possible functions
and mechanisms of lncRNAs in epigenetic regulation to target genes in the progression of DR.
Targeting Glioma Cells with Nutraceuticals: Therapeutic Effects Based on
Molecular Mechanisms, New Evidence and Perspectives
Authors: Salami Marziyeh , Salami Raziyeh , Aarabi Mohammad-Hossein , Mafi Alireza , Ghorbanhosseini Seyedeh Sara , Shafabakhsh Rana , Asemi Zatollah
Published: June 2022

Gliomas are the most common malignant cancers of the brain that have unregulated proliferation
and are known as highly invasive tumors. Hence, their relapse rate is high, and the prognosis is
low. Despite remarkable advances in neuroimaging, neurosurgery, and radiation therapy, they, especially
glioblastoma, are highly resistant to treatments, including radiotherapy, surgery, and temozolomide
chemotherapy. The average survival rate for patients with malignant glioma is still less
than two years. Accordingly, the search for new treatment options has recently become an urgent
need. Today, a number of nutraceuticals have been considered because of their special role in inhibiting
the angiogenic process, metastasis, and apoptosis, resulting in the inhibition of tumor growth, including
glioma. Nutraceuticals can disrupt cancer cells by affecting different pathways. In fact, these
compounds can reduce the growth of cancer cells, inhibit their proliferation and angiogenesis, as well
as induce apoptosis in these cells and play an important role in various stages of treatment. One of the
key targets of nutraceuticals may be to regulate cellular signaling pathways, such as
PI3K/Akt/mTORC1, JAK/STAT, and GSK-3, or to exert their effects through other mechanisms, such
as cytokine receptors and inflammatory pathways, reactive oxygen species, and miRNAs. This review
refers to the results of recent studies and target molecules as well as signaling pathways affected by
some nutraceuticals in glioma cells. These studies indicated that clinical trials are imminent and new
approaches can be beneficial for patients.
A Comprehensive Review of Soluble Epoxide Hyådrolase Inhibitors Evaluating
their Structure-Activity Relationship
Authors: Tabatabai Sayyed Abbas , Nazari Maryam , Rezaee Elham
Published: June 2022

Soluble epoxide hydrolase is a class of α/β-fold hydrolase enzymes that exist in numerous organs and tissues, including the liver, kidney, brain, and vasculature. This homodimer enzyme is responsible for degrading epoxyeicosatrienoic acids to the less active vicinal diols, dihydroxyeicosatrienoic acids through adding a molecule of water to an epoxide in the cytochrome P450 pathway. Soluble epoxide hydrolase was firstly assayed and characterized by Hammock and colleagues about 40 years ago. Upholding high epoxyeicosatrienoic acid blood levels by inhibiting soluble epoxide hydrolase has been proposed as a hopeful strategy to treat renal and cardiovascular diseases, inflammation, and pain. Therefore, developing novel soluble epoxide hydrolase inhibitors has been an attractive research topic for many years. Regarding this issue, some carbamates, heterocycles, amides, and ureas have been proposed; however, rapid metabolism, low solubility, high melting point, and weak pharmacokinetic characteristics are challenges posed to the researchers.
In this review, we have focused on the role of the soluble epoxide hydrolase in the metabolic pathway of arachidonic acid, and categorized most representative soluble epoxide hydrolase inhibitors into two main classes of synthetic and natural compounds. The structures have been evaluated and an exemplary structure-activity relationship has been provided for further development of potent inhibitors at the end. According to our findings, urea-based inhibitors were preferred to the amide-based scaffolds due to the better fitting into the active site. An aromatic linker is a suitable bridge to connect primary and secondary pharmacophores compared with aliphatic linkers.
Celebrating a Century of Insulin Discovery: A Critical Appraisal of the Emerging Alternative Insulin Delivery Systems
Authors: Sibiya Ntethelelo , Mbatha Bonisiwe , Ngubane Phikelelani , Khathi Andile
Published: June 2022

Since the discovery of insulin, continuous developments of this peptide have led to better management of diabetes mellitus, thus leading to a decrease in diabetes-related mortality. Despite these developments, we have seen an increase in diabetes cases, which has further necessitated more innovative methods for diabetes management. The subcutaneous administration of insulin remains the mainstay therapy for type 1 diabetes mellitus. However, despite the availability of insulin analogues with improved pharmacokinetics, challenges with conventional administration exist. The challenges associated with insulin injections include hypoglycaemic episodes, needle phobia, and injection-site inflammation, which all have been reported to reduce patient compliance. Ongoing research on diabetes management strives to develop therapies that provide improved glycaemic control with minimal side effects. In part, for these reasons, we have seen an increase in the search and development of alternative insulin delivery systems that are envisaged to circumvent the shortfalls associated with the conventional administration route. Several alternative drug delivery systems, such as oral, pulmonary, buccal, nasal, and transdermal, have been explored in the last century. These efforts have not been without victory, as we have seen the emergence of pulmonary (Exubera and Afrezza) and buccal insulin delivery systems licenced for therapeutic use. Despite the success seen in these two systems, their marketability and popularity have been severely compromised due to reported safety concerns. Although oral insulin delivery has always shown promise in the past decades; however, it was only limited to preclinical trials. The main challenge associated with this delivery route is poor bioavailability, which necessitates high insulin concentration to be administered. Due to recent developments, oral insulin has reached phase 3 clinical trials. It is believed that patients would prefer oral insulin as their preference is often observed for oral antidiabetics over injected ones. In the last decade, transdermal insulin has also gained interest, where delivery of insulin with a concomitant reduction in blood glucose concentration has been demonstrated in vivo. However, at present, there are no clinical studies that have reported the efficacy of transdermal insulin administration. With technological advancement, there is a potential to develop yet another insulin delivery system that would likely enter the markets. As these novel delivery systems have been found to be effective, emerging competing products should be welcome and appreciated.
Promising Essential Oils/Plant Extracts in the Prevention and Treatment of Dandruff Pathogenesis
Authors: Kumari KM Uma , Yadav Narayan Prasad , Luqman Suaib
Published: June 2022

Background:

Dandruff is a scalp malady affecting predominantly the male populace. Topical agents and synthetic drugs used for dandruff treatment have specific side effects including burning at the application site, depression, dizziness, headache, itching or skin rash, nausea, stomach pain, vision change, vomiting, discoloration of hair, dryness or oiliness of the scalp and increased loss of hair. Thus, essential oils and extracts from plants could be valuable in the treatment and prevention of dandruff.

Aim & Objective:

This review aims to highlight current findings in dandruff occurrence, its etiology, promising plant essential oils/extracts, and novel treatment strategies. The main emphasis has been given on the anti-dandruff effect of essential oils and plant extracts to disrupt microbial growth. The proposed mechanism (s) of action, novel approaches used to perk up its biopharmaceutical properties, and topical application have been discussed.

Results:

The literature survey was done, bibliographic sources and research papers were retrieved from different search engines and databases, including SciFinder, PubMed, NCBI, Scopus, and Google Scholar. The selection of papers was accomplished based on exclusion and inclusion criteria. The scalp of diverse populations revealed an association of dandruff with microbial symbiosis, including Staphylococcus, Propionibacterium, Malassezia, and Candida as the pathogens responsible for the cause of dandruff. Topical antifungals are considered as the first line of treatment for dandruff including azoles, with clotrimazole (1%), ketoconazole (2%), and miconazole (2%). Other commonly used therapies integrate benzoyl peroxide, coal tar, glycerin, zinc pyrithione, lithium succinate/gluconate, salicylic acid, selenium disulfide/sulfide, sodium sulfacetamide, etc. However, these medicaments and chemicals are known to cause specific side effects. Alternative therapies, including tea tree oil, thyme, Aloe vera, Mentha have been reported to demonstrate anti-dandruff activity by disrupting the microbial growth associated with dandruff formation.

Conclusion:

Overall, this review explains the occurrence of dandruff, its etiology, and the potential applicability of promising plant essential oils/extracts, and their novel treatment strategies. Further studies based on pre-clinical and clinical research are essential before making any conclusion about its efficacy in humans.
The Need for Artificial Intelligence in Cancer Nanomedicine
Authors: Dilnawaz Fahima
Published: June 2022

Clinicians today face challenges in dealing with the complexity of data, as
deriving meaningful insights from it requires a lot of time and effort. In this scenario,
artificial intelligence (AI) holds tremendous promise. To deal with a large amount of
data, AI would certainly offer new ways to provide clinical decision support as well as
it will speed up the workflow. Generation of large data through the cancer
nanomedicine programme, AI would be of great help to clinicians.
Artificial Intelligence and its Application in Cancer Nanomedicine
Authors: Mohanty Sweta , Acharya Sarbari , Mohanty Chandana
Published: June 2022

The applications of artificial intelligence and nanotechnology have been
increasing in various sectors of society, particularly the pharmaceutical industry. The
amalgamation of these two domains is allowing for improved patient data acquisition
and the design of nanomaterials for precision cancer medicine. The crosstalk between
the tools and techniques utilized in AI could improve the design of nanomedicine by
improving material properties and the selection of drug combinations. To this end, this
review discusses nanotechnology coupled with AI and its possible applications in the
future of precision cancer medicine.
Deep learning small arms recognition
Authors: Bajon Theò
Published: June 2022

The automated detection, recognition, and identification of small arms through deep learning tools is a recent process that seems to offer interesting possibilities in the field of conventional disarmament. As the field of research has so far mainly focused on detection models in the context of domestic security, it is interesting to explore, in this paper, the development of a basic small arms recognition model and its potential use in the field of conventional disarmament; this paper lays the foundations of a basic small arms recognition model through its development using deep learning tools and its experimental testing. The initial results of the basic model developed in this paper put in perspective the foundations for improvement towards a developed recognition model and towards a complex identification model of small arms. Moreover, this paper also puts in perspective the potential of such models in the field of conventional disarmament.