bluuebunny/crossref_metadata_2025 huggingface dataset:
Video-based visualization of debugging process
Authors:   Ukrainian State University of Science and technologies, Shynkarenko V.I. , Zhevaho О.O. ,   Ukrainian State University of Science and technologies
Published: February 2025

One of the current trends in education is microlearning, which involves the use of short videos in the learning process. Microlearning has a number of advantages, including the fact that this approach is more student-centered, aims to increase the level of knowledge assimilation, requires less time for learning, and allows learning anytime and anywhere. In previous works, the authors have developed a constructive production model and corresponding software for tracking programmer's actions during the preparation of program text and debugging in the Visual Studio development environment. This article presents an extension of these software tools. Based on the collected information in the log files about the program debugging processes, their visualization is performed, which reproduces the sequence of actions during the original debugging process. The goal is to increase the efficiency and effectiveness of programming education. The video-based visualization demonstrates the programmer's work on preparing and correcting the code during debugging and is synchronized with the time stamps in the log files only during periods of activity. Comments are overlaid on the video, providing explanations and suggestions for improving the debugging process. Comments help to understand the rationale for specific actions taken during debugging and provide guidance on how to improve processes or use alternative approaches. The benefit of visualization for the teacher is the ability to: analyze the debugging process of a particular student, identify typical mistakes of a particular group of students, adjust the teaching process accordingly, and provide targeted assistance in improving debugging skills. Benefits for the student: the ability to analyze your own work, develop critical thinking on how to improve it, and receive timely assistance from the teacher.
Semantization of WIKI resources: tools, advantages and implementation specifics
Authors:   Institute of Software Systems NAS of Ukraine, Rogushina J.V.
Published: February 2025

Proposed article analyses advantages provided by the semantization of wiki resources and the problems that need in solving for its practical implementation. We considere basic functional components of semantic search and specify this umbrella term for wiki technologies. Such search is grounded on structured queries that use semantic properties of information objects represented into wiki resources and possibilities of search language that states such queries. The criteria for evaluating search languages and means of semantic structuring of resource content are analyzed. We define additional opportunities that the use of the Semantic MediaWiki plug-in provides for the oresources built on the MediaWiki technological platform. The expressive possibilities provided by Semantic MediaWiki for building semantic queries are considered, the main components of such queries and their purpose are determined. Semantization of already existing wiki resources differs from the development of semantic ones, and we compare main steps of these processes and specifics of use the ontological model in them. This model provides an unambiguous interpretation of the relations between typical information objects represented into the resource, their properties and restrictions. Proposed approaches to semantization are tested on three independent information resources of different types that use the wiki technological platform for collaborative processing of distributed data and knowledge. They can be useful for making decisions about the expediency of semantization of information resources with different scope and purposes and for determining the most effective ways of implementing the chosen solution. We use the experience of developing the knowledge base of the wiki-based portal version of the Great Ukrainian Encyclopedia e-VUE that has a large volume, a complex structure and contains a large number of various heterogeneous information objects.
Missed Opportunities to Address SNAP for Nonenrolled Children
Authors: Geanacopoulos Alexandra T. , Branley Claire E. , Garg Arvin , Samuels-Kalow Margaret E. , Gabbay Jonathan M. , Peltz Alon
Published: February 2025

BACKGROUND

Primary care is an important setting to identify and support children who are eligible but not enrolled in the Supplemental Nutrition Assistance Program (SNAP) (the SNAP Gap), although there is concern that these programs may be limited in reach. We sought to identify patterns of health care use among eligible but unenrolled children.

METHODS

We conducted a cross-sectional analysis of the 2021 Medical Expenditure Panel Survey. We identified 975 SNAP eligible/nonenrolled children with household incomes less than 200% of federal poverty level. SNAP eligibility was modeled using income, employment, and household composition and SNAP enrollment was self-reported. We categorized health care encounters across 9 visit types and calculated annual primary care attendance rates. Multivariable logistic regression was used to measure associations with race, language, and chronic conditions.

RESULTS

SNAP eligible/nonenrolled children received an average of 6.04 health care encounters in 2021. Only half (52.9%) received a primary care visit. Primary care attendance was lowest for Black children (odds ratio [OR] = 0.40 [95% CI 0.20–0.81], P = .01), children speaking languages other than English (OR = 0.53 [95% CI 0.32–0.89], P = .02) and children without a chronic condition (OR = 0.08 [95% CI 0.04–0.15], P < .001). Visits to medical specialists (20.4% of all visits), behavioral health clinicians (10.9%), and dentists (10.0%) were the most common nonprimary care services received by SNAP eligible/nonenrolled children.

CONCLUSION

In a nationally representative sample of children who were potentially eligible but nonenrolled in SNAP, we found low primary care attendance in 2021 with evidence of racial and linguistic disparities. Clinicians beyond the primary care system are well positioned to support children who jointly underuse government nutrition programs and primary care services.
“Problems Encountered in Distant Learning Relative to Reading Skills Among Grade 10 Students, Talibon District, Bohol”
Authors: Celocia Naue , Sapong Charito
Published: February 2025

This study deals with the problems encountered in distance learning among Grade 10 students of Talibon District I relative to their reading skills.  The study focuses on students’ problems in in terms of internet connection and electricity problems, inadequate and vague learning resources, overloaded lesson activities, conflict with home responsibilities, financial-related problems, and physical and mental health compromises. parent’s highest educational attainment, family income, and parent’s livelihood means. The PHIL-IRI results of the students were the data for the student’s reading skill level. It seeks to check the significant degrees of relationship, correlation, and difference between and among variables.            The method used the descriptive-correlational design of the quantitative research method and descriptive-correlational questionnaires, which determined the respondents’ problems in distance learning. In addition, it used a documentary analysis to gather the results of Phil-IRI. It is found that the majority of the students have parents with a high school education and work as farmers with less than P5,000.00 monthly income. Moreover, among the six problems encountered in distant learning, ranking first is ‘conflict with home responsibilities and poor learning environment’, which is interpreted as moderately serious. Their reading skills are alarming as they belong to the lowest ‘frustration level’.
Perception Of the Mother Tongue-Based-Multilingual Education Implementation: Basis for Course Enhancement
Authors: Israel Marieson , Jumawid Jennifer , Cortez Daniel , Fronteras Vanessa , Lapac Jastin Jake , Boldo Jana Ethel Marie , Tubil Janice Mae , Owens Hydie , Inguito Vesmilicar
Published: February 2025

The purpose of this study is to assess the perception on the implementation of MTB-MLE and to know that teachers and school administrators have given proper attention and support to implement the MTB-MLE program effectively. Considering its implementation, the program brings challenging situations in terms of language policies especially on the five (5) elementary schools that are involved in the study. These schools are; Guiwanon Elementary School, Miguel Oppus Memorial Elementary School, Montana Elementary School, Baclayon Central Elementary School, and Laya Elementary School all in the District of Baclayon. These five (5) along the highway schools of Baclayon were also among the schools that were categorized as big and medium schools.  This study utilizes the purposive descriptive-normative survey method of research. The researchers utilized a survey questionnaire in order to obtain the needed data and responses. Moreover, the contents reflected in the assessment as to the attainment of objectives of MTB-MLE was premised on the copy containing the competencies of the MTB-MLE.   There are two (2) groups of respondents involved in this present study. They are the school administrators or the complete enumeration of the school heads and the elementary school teachers handling MTB-MLE in these five (5) basic elementary schools, specifically the Grades 1 to 3 teachers. There were five (5) school administrators who served as the first pool of respondents. All of these five (5) were females.
Zewnętrzne warunki twórczości w edukacji estetycznej w świetle wypowiedzi absolwentów szkół ogólnokształcących. Komunikat z badań jakościowych
Authors:   Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Polska, Lisiecka Alicja
Published: February 2025

The development of creative abilities is crucial for the holistic development of an individual. If the goal of schooling is the comprehensive development of students, the educational environment should stimulate and support processes of creative thinking rather than hinder or block them. One area of education particularly associated with creativity is aesthetic education. By encouraging exploration and interpretation of art and other forms of artistic expression, aesthetic education supports the emotional, intellectual, and social development of students, enabling them to express themselves in original and personal ways, which is essential for cultivating a creative attitude. This article addresses the issue of external factors affecting creativity within aesthetic education implemented in general education schools, specifically in the subjects of visual arts, music, and Polish language. The research process is guided by the question of external conditions influencing creativity in aesthetic education and their potential significance for students’ creative development. The article presents the results of qualitative research conducted through individual interviews with 25 graduates from the 2022/2023 school year. The experiences shared by respondents highlight numerous factors that, according to existing literature, hinder the development of a creative attitude. The research is exploratory in nature.
Does Mutual Fund Fragility Impact Primary Market Pricing? Evidence from Commercial Paper
Authors: Li Yi , Tibay Sean , Wang Ashley W.
Published: February 2025

Investor flows in open-end mutual funds, along with their inherent liquidity mismatches and potential fragility risks, can significantly impact the pricing of assets these funds invest in. While much of the existing research has focused on these effects within the secondary markets for equities and bonds, this note, based on a working paper by Li, Tibay, and Wang (2024), provides evidence on how shocks from investor flows in prime money market funds (MMFs) influence the pricing and issuance in the primary markets for commercial paper (CP).
Análisis de depresión en adolescentes de básica secundaria y media usando algoritmos de machine learning
Authors: GARCIA SAAVEDRA YURI MARCELA , SALINAS FLORES JESÚS WALTER , GARCÍA SAAVEDRA MARÍA DEL PILAR
Published: February 2025

Objetivo: Identificar los factores determinantes relacionados con la ansiedad, el estrés y la depresión en adolescentes de sexto a undécimo grado de una institución educativa del departamento del Tolima, Colombia.
Método: Se aplicó el Inventario Sistémico Cognoscitivista para el estudio del estrés académico (Inventario SISCO) a una muestra de 553 estudiantes cuyo rango de edad estuvo entre 11 y 20 años (media=17,12 años, DE=0,766). Se emplearon diferentes algoritmos de Machine Learning para clasificación debido a que la variable target es de respuesta binaria, complementando con el uso de métodos de ensamble.
Resultados: Al preguntarle a los estudiantes si alguna vez habían tenido sentimientos persistentes de tristeza, sensación de vacío o pérdida de interés en las actividades cotidianas (indicativos de depresión), el 76,17 % manifestaron que sí mientras que el 23,83 % respondió que no. La probabilidad de detectar correctamente a los estudiantes con depresión fue de 0,845, mientras que para los estudiantes que no manifiestan tener depresión fue de 0,863. Las principales variables que mejor discriminaron entre estudiantes que afirmaron tener síntomas de depresión y aquellos que no, fueron: fatiga crónica, dificultad para tomar decisiones, ansiedad, falta de apetito, conflictos interpersonales, actividades evaluativas y somnolencia.
Conclusiones: Se recalca la importancia de la detección temprana, la utilización de herramientas de Machine Learning, y la necesidad de enfoques preventivos y personalizados para abordar la ansiedad, el estrés y la depresión en adolescentes.
Uso y abuso de videojuegos en jóvenes y adolescentes del País Vasco. Relación con variables sociodemográficas e interpersonales
Authors: González-Álvarez Sara , Solabarrieta Josu , Ruiz-Narezo Marta
Published: February 2025

Objetivo: Analizar variables sociodemográficas e interpersonales y la relación que estas tienen con el uso y abuso de videojuegos.
Método: Se han analizado los datos de la encuesta Drogas y Escuela X, realizada por el Instituto Deusto de Drogodependencias y financiada por el Gobierno Vasco. La muestra está compuesta por 6209 jóvenes, de 12 a 22 años, que cursan enseñanzas secundarias en País Vasco, siendo un 52,6 % hombres. La media de edad de la muestra es de 15,1 años (DE=2,8). La muestra ha sido seleccionada por un muestreo por conglomerados bietápico. Se han medido las horas diarias de uso (durante la semana y los fines de semana) de videojuegos y juegos online. Para medir las variables predictoras se han utilizado varias preguntas, estas variables incluyen la relación con los y las iguales, la participación social y el ocio, el tiempo libre y la vivencia escolar.
Resultados: Se han encontrado diferencias en el uso diario de videojuegos y juegos online, así como diferencias significativas en función del sexo y la edad. También se han hallado correlaciones entre el uso de videojuegos y juegos online con ciertas variables interpersonales.
Conclusiones: Las personas jóvenes que no están correctamente integradas en su entorno social offline, con sus iguales y en la escuela pueden desarrollar conductas problemáticas, como un uso abusivo de los videojuegos. Un correcto abordaje puede influir en la relación que las personas jóvenes tienen con la tecnología, pudiendo evitar el desarrollo de conductas problemáticas.
Prevention of HPV-associated cervical pathology in the 21st century
Authors: Grineva Alina Alexandrovna , Ansarova Sabina Mubarizovna , Basalova Julia Vyacheslavovna , Heydarova Aida Elshan kyzy , Obukhova Elena Павловна , Romanenko Marina Sergeevna , Raevskii Kirill Pavlovich
Published: February 2025

Human papillomavirus (HPV) is a major pathogen in the development of cervical cancer. Papillomavirus infection is widespread throughout the world. Comprehensive prevention of high-oncogenic risk HPV infection is the main goal for reducing the incidence of cervical cancer. Drawing attention to this problem, expanding the scope of vaccination, developing modern vaccines and diagnostic methods, raising public awareness - all this will help to accelerate the achievement of the presented goal.
This literature review collects the latest information on existing methods of HPV prevention and diagnosis, and also considers further plans for solving this problem in the near future. The article demonstrates the latest results of Russian and foreign research. We analyzed the approach to this problem in Russia and other countries of the world. The statistics of cervical cancer prevalence in the Russian Federation and foreign countries is shown, morbidity and mortality rates are outlined. A clear pattern of decreasing cervical cancer incidence rates in countries with already introduced screening and vaccination programs for the population against HPV is revealed. The key risk factors associated with both the virus and the human lifestyle are presented. The main mechanisms of HPV oncogenesis, preventive screening programs aimed at identifying dysplastic changes and preventing the development of invasive types of cancer are presented, and the topic of vaccine prophylaxis is raised - the vaccines registered in the world and ongoing research on the development of new vaccines, their effectiveness and safety are considered.
Beyond Populism and Plutocracy: Aretecracy as a New Democratic Paradigm
Authors: Arrieta-López Milton
Published: February 2025

Aretecracy is presented as an alternative to the current democratic models, facing the contemporary problems of populism and plutocracy. The purpose of this study is to analyze the potential of Aretecracy as a governance paradigm based on virtue and ethics, proposing a framework to respond to the ethical and structural crises facing modern democracies. Methodologically, a theoretical-analytical approach is adopted, critically reviewing existing literature on democratic theory and applying these concepts to the design of an ethical pre-qualification system for political leaders. The results demonstrate that Aretecracy can offer a viable governance model by integrating ethical criteria into the leader selection process, ensuring that those who hold public office are both morally competent and technically qualified. Furthermore, the study explores how Aretecracy could be implemented in various sociopolitical contexts, fostering a political culture based on excellence and integrity. The conclusions emphasize the need to reform current democratic systems by incorporating mechanisms of ethical pre-qualification to strengthen the legitimacy and efficiency of governments, ensuring that political decisions align with the collective well-being and human rights.
Violencia contra la mujer en Ecuador: una perspectiva desde la justicia social y legal
Authors: Guillén de Romero Jacqueline Coromoto , García Castro Luis Antonio , Ortiz Baque Vielka Mayerli , Boscán Carroz Mariby C.
Published: February 2025

La violencia contra la mujer en el Ecuador constituye un grave problema que afecta a todo el entorno familiar y social. El objetivo de la presente investigación se fundamentó en, analizar la violencia contra la mujer de acuerdo con la normativa y desde la perspectiva de justicia social, a partir de ahí, se examinó si la ley establecida hacía el combate de este tipo de violencia son propicias y necesarias para precautelar el bienestar integral de la mujer y su entorno. La investigación se direccionó bajo un tipo de estudio cualitativo y método analítico, mientras que, la técnica empleada parar la recolección de las percepciones de los agentes judiciales y sociales fue la entrevista semiestructurada y antropológica. Con los resultados se identificó que, si bien ha habido avances en temas de protección de la mujer, existen muchos temas en los cuales se debe avanzar en pro y respeto de los derechos humanos. Los expertos en la materia, utilizando técnicas de análisis rigurosas, indican que Ecuador aún necesita evolucionar en términos de legislación penal contra la violencia hacia la mujer. En esta línea, el prosperar en temas de protección hacia la violencia contra la mujer es salvaguardar a la sociedad y el entorno familiar al darle un trato justo a esta situación.
Justicia Constitucional y Democracia: Principio Contramayoritario en las Decisiones de la Corte Constitucional Colombiana
Authors: De León Llanos Alejandro Abraham , Guette Hernández David Modesto
Published: February 2025

El principio contramayoritario es un elemento fundamental en la comprensión de las democracias modernas. Este cuenta con un desarrollo teórico robusto y se encuentra consolidado en el constitucionalismo contemporáneo, señalando que el poder debe ser limitado y controlado, a fin de evitar que la mayoría legisle o gobierne violando los derechos y libertades de las minorías. En esta medida, la figura del tribunal constitucional, como intérprete supremo de la constitución, juega un papel crucial en la protección del principio en cuestión. Por ello, el presente artículo se centra en examinar e interpretar las bases teóricas y prácticas del principio contramayoritario, de cara al papel de los tribunales constitucionales en su implementación, como manifestación de la justicia constitucional en contextos democráticos. Todo esto enmarcado dentro de una investigación jurídica, la cual se desarrolla a partir de un método analítico, que se plantea a partir de la revisión documental de la doctrina y la jurisprudencia relevante sobre el tema, teniendo mayor proximidad con el contexto colombiano. Con este artículo se contribuye a la comprensión del principio en cuestión desde su fundamentación teórica y su injerencia en la actualidad jurídico-política, a través de su impacto en las dinámicas judiciales que han venido determinando el curso y evolución de las democracias contemporáneas. Se concluye con que el principio contramayoritario, pese a verse usualmente cuestionado por sus dificultades metodológicas, producto del carácter indeterminado de su insumo social, desempeña un papel crucial en la comprensión de los límites contemporáneos al poder.
A.P. Sumarokov and the Formation of Russian Romance
Authors:   Russian State Pedagogical University named after A.I. Herzen, Yanitzkaya S.S.
Published: February 2025

The role of A.P. Sumarokov in the development of the genre of
romance in Russian XVIII-century poetry is considered. The specific
features of the early Russian romance as a lyrical genre are elucidated
in its interaction with the genre of elegy.
Problems of Reforming the Higher Education in Russia in the Conditions of Economic Crisis
Authors:   Saratov State University, Malinsky I.G.
Published: February 2025

The article analyses a number of problems of further reforming the
higher education in modern Russia under the influence of new economic situation in the world.
Urban theory and Practice of Literary Modernism: Georg Simmel’s Essay «The Metropolis and Mental Life» and the Modernist Groβstadtroman
Authors:   Saratov State University, Kabisov A.G.
Published: February 2025

The article analyses one of the fundamental texts of urban theory –
Georg Simmel’s essay «The Metropolis and Mental Life» (1903). Like
other works of German thinkers at the turn of the twentieth century,
Simmel’s interpretation of urban experience is shown to correlate with
literary images of the city produced by modernist Groβstadtroman.
Aspects of metropolis, elucidated by Simmel, provide structural patterns for the genre.
To the Forms of Determinism in sociology
Authors:   Saratov State University, Rovnova S.A.
Published: February 2025

The article considers the problems of applying the principle of social
determinism in social science. It analyzes various forms of determinism such as geographical, ecological, demographic, cultural, social
determinism, etc. It shows the role of this principle in modern sociology.
Social Political Differentiation of Electoral Moods of the Population of the Ukrainian SSR after World War II
Authors: Stasiuk Oleksandra
Published: February 2025

In this paper, the main manifestations of the electoral moods of the population of the Ukrainian SSR during the elections to the Supreme Soviets of the USSR, the Ukrainian SSR and local authorities in 1946–1947 are considered. The generally low level of interest of the population in political actions, such as election campaigns, is emphasised due to the difficult social political and economic situation in the state. The factors that determine the electoral behaviour of voters and the causes of social deviations are analysed. The paper presents the stratification of citizens’ electoral moods according to socio-political indicators and in the regional dimension, describing in detail the attitude to the elections of such social groups as workers, peasants, petty bourgeois, intelligentsia, women, etc. It is noted that the geography of critical statements proves the similarity of the electoral moods of the population in different regions of the Republic. However, the motivation for the protests and their public manifestation by the residents of ‘Great Ukraine’ (i.e., eastern and central Ukraine, which was under the rule of the Russian Empire and the USSR) and the western region are radically different. If, in most of the territory of the Ukrainian SSR, citizens accepted the demands of the authorities and were included in the electoral process, Western Ukrainians massively boycotted them. The boycott of the elections by the Western Ukrainian population was caused by a protest against the repeated forced Sovietisation of the region, the predatory economic policy of the authorities, as well as repressions against participants in the national liberation movement. Equally, Western Ukrainians protested primarily for ideological reasons, not accepting the values of the Soviet power and considering it an occupational force, while for the inhabitants of Great Ukraine, the everyday, material aspect turned out to be the most critical issue.
Une vue non conformiste des problèmes forestiers du monde
Authors: Huguet Louis
Published: February 2025

Ce document pose une question essentielle à la fois sur l'avenir de la forêt et sur la production agricole dans les pays en voie de développement, tropicaux ou méditerranéens secs en général. La question est la suivante : la productivité agricole de ces pays peut-elle suivre la même évolution que celle des pays dits « développés » aux XVIIe et XVIIIe siècles et même récemment, c'est-à-dire où les céréales, les fruits, la viande, le lait, etc. abondent et où les forêts sont stables ou prospères ? Dans les pays en développement, la conservation des forêts dépend de la réponse à cette question, qu'elle soit négative ou positive. La conclusion de l'article est que « l'agriculture saine est une condition préalable à la sylviculture saine ».
Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy
Authors: Lee Hyunchan , Hikosaka Okihide
Published: February 2025

Animals navigate environments with multiple objects to find rewards. We previously found that phasic activities of lateral habenula (LHb) neurons encode step-by-step changes in reward predictions induced by the series of multiple objects and errors. However, to obtain the reward, another important source would be to maintain their mind at the beginning and tolerate capricious errors in following steps to continue the sequence of actions. We found that periaqueductal gray (PAG) neurons, LHb downstream brain area, transport reward expectation from one step to the next step, affecting subsequent behaviors. The tonic PAG activities correlated with animal behavior responding to a cue and also contextually affected subsequent behaviors (vigorous reaching and holding). This research suggests that phasic and tonic signaling in the LHb-PAG pathway plays a crucial role in deciding the continuation versus discontinuation of reward-seeking behaviors in the sequential steps and enables animals to search complex environments and find rewards.
Biomimetic Breakthrough: Enhancing Tendon Repair with dAM- TDSCs
Authors: Mao Xufeng , Wang Yulong , Zhang Xiqian , Yao Zheyu , Yuan Zheyang , Yao Liwei , Wang Leining , Mao Haijiao
Published: February 2025

Background
Adhesions and poor healing are major complications after Achilles tendon injury, and there is no effective solution to this problem. The purpose of this study is to determine whether the biomimetic peritoneurosis can solve the above problems in the process of Achilles tendon healing;
Methods: Our studies investigated the adhesion and proliferation of tendon-derived stem cells (TDSCs) on dAM in vitro, as well as their tenogenic differentiation. The effects of Achilles tendon rupture on tendon regeneration were assessed in vivo by using an Achilles tendon rupture model in rats; Finally, from in vitro mRNA transcriptome sequencing combined with in vivo Achilles tendon protein to omics analysis to explore the repair mechanism of Achilles tendon rupture. Student's t-tests were used to assess the significance of observed differences between the two experimental groups. Multiple groups were compared using one-way analysis of variances (ANOVAs), followed by post hoc Bonferroni comparisons.
Results: The main findings of this study are that cell adhesion, proliferation, and differentiation of TDSCs were enhanced by dAM. Implanted dAM + TDSCs significantly accelerated tendon regeneration in vivo. In addition, extracellular matrix-related differential genes and proteins were screened by mRNA transcriptometry in vitro and proteomic analysis of Achilles tendon in vivo, and ERK signaling pathway was further explored to participate in the repair of Achilles tendon rupture.
Conclusions: The dAM-TDSCs composite biomimetic peritendinous membrane material can effectively promote the healing of Achilles tendon. It provides a new direction for the development of biomimetic peritendinous membrane materials.
The role of demographic characteristics and shopping habits in online shopping behavior
Authors: Balogh-Kardos Valentina , Balogh Renátó , Gál Tímea
Published: February 2025

E-commerce is a prospering industry, its global market size has doubled in recent years and, in addition to volume growth of more than 100%, its market share is constantly increasing. There has been a significant change in the information search phase of purchase decisions recently, which appears in a differentiated manner in generations. Social network sites have become the primary sources for the members of the young generation (Generation Y and Z) these days. The paper explores the habits of Hungarian online consumers and the factors influencing them. A quantitative data collection tool was selected as a method of the research, including an online questionnaire survey with 720 respondents. Based on the results, it can be concluded that most respondents have integrated monthly online shopping in their lives, and they browse offers online on a weekly basis. With respect to product categories, clothing products and electronic items were among the most frequently purchased, in terms of delivery, most people prefer delivery by courier service, while regarding payment methods, credit card payment is preferred. After conducting Principal Component Analysis, the research identified six factors that influence online purchase, including convenience, risk, time efficiency, social media, logistics, and availability. The hypothesis tests revealed significant differences along all variables related to demographics and shopping habits.
AcknowledgmentSupported by the University of Debrecen Program for Scientific Publication.
Power generation dispatching and risk analysis of the Qingjiang cascade hydropower stations under climate change
Authors: Li Yinghai , Huang Rubao , Meng Hongchi , Soomro Shan-e-hyder , Zhang Hairong , Guo Jiali , Li Changwen , Wang Yongqiang
Published: February 2025

Climate change alters river runoff regimes, affecting the safe operation of hydropower stations. This study proposed an optimization scheduling and risk analysis framework for cascade hydropower under climate change using the Qingjiang cascade hydropower stations as a case study. The framework has three stages. Firstly, a hydrological model coupling GCMs with SWAT under CMIP5 scenarios is established to predict future runoff. Secondly, cascade hydropower optimization scheduling under climate change is performed using the POA (Progressive Optimization Algorithm). Thirdly, a risk assessment index system is established, including risks of insufficient power generation, insufficient output, and water abandonment. The POMR (Probability Optimization Method for the Risk) is applied to calculates power scheduling risks. Results show that the simulated annual average runoff at Changyang Station increases by 6.0, 8.7, and 13.2% under the RCP2.6, RCP4.5, and RCP8.5 scenarios, respectively. Annual power generation for the Qingjiang cascade is projected to rise by 6.2–16.5%, with increases of 5.2–12.9% during flood seasons and 7.5–19.9% in non-flood seasons. Comprehensive risk rates decline to 0.1767, 0.1706, and 0.1630 across the scenarios. This research provides scientific and technical support for managing water resources and operating the Qingjiang cascade under climate change.
Impact of types of water source on pipeline corrosion: a comprehensive electrochemical and microscopic analysis
Authors: Lv Zhisheng , Song Guanyong , Zhao Shanshan , Jin Binbin , Xiao Hua , Guo Yabin , Wang Ao , Xu Hang
Published: February 2025

Switching water sources is essential for effective water resource management and pipeline maintenance, ensuring water supply stability and reducing reliance on a single source. However, improper water source selection can disrupt the chemical balance within pipelines and accelerate corrosion. This study simulated the process of switching water sources and employed electrochemical analysis, such as scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy, to investigate the impact of water source switching on pipeline corrosion. During the initial switching phase, severe pipeline corrosion was observed, along with significant variations in water quality indicators that substantially influenced corrosion. Electrochemical analysis revealed a decrease in pipeline open circuit potential and a negative shift in the polarization curve, indicating an increased tendency for corrosion. Corrosion could be relieved as the pipeline adapted to the new water quality. Microscopic analysis demonstrated that switching water sources affected the structure and stability of the corrosion product film. Investigations into different water source switching ratios indicated that corrosion levels should not be evaluated based on a single parameter; an appropriate blend of water sources is necessary to effectively mitigate corrosion. This study provides valuable insights for water source management, pipeline maintenance, and efficient water supply strategies.
In vivo Pharmacokinetic and ADMET Profiles of Synthetic Antimicrobial Peptides (AMPs): A Review
Authors: Noordin Muhammad Akram Mohd , Najm Ahmed Abdulkareem , Dyari Herryawan Ryadi Eziwar , Law Douglas , Alwi Sharifah Sakinah Syed , Lazim Azwan Mat , Cheah Yew Hoong , Tee Thiam Tsui , Fazry Shazrul
Published: February 2025

The broad-spectrum action and capacity to target drug-resistant infections make synthetic
Antimicrobial Peptides (AMPs) popular therapeutic agents. Indeed, the effective use of these
peptides in clinical application relies on a thorough understanding of their Pharmacokinetic (PK)
and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) characteristics.
Despite growing research on synthetic AMPs, there is a notable gap in the literature specifically
addressing their ADMET profiles. Previous reviews have not extensively covered this area,
providing a vital opportunity to study synthetic AMPs' pharmacokinetics and safety, which are
crucial for their therapeutic development. This review covered research studies that focused on PK
and ADMET of synthetic antimicrobial peptides from several databases, including Google Scholar,
SCOPUS, PubMed, and Science Direct, within the years 2020 to 2024, and 12 related research papers
have been found. AMPs display a wide range of PK behaviors, including rapid renal clearance,
liver-centric distribution, broad distribution with low toxicity, high kidney retention, and gradual
absorption with dose-dependent toxicity. Overall, the ADMET profiles of AMPs are crucial in
assessing their therapeutic potential, and continuous study is necessary to enhance their practical
feasibility. An in-depth investigation of the in vivo ADMET and pharmacokinetic profiles of
synthetic AMPs is presented in this review to address the current gap in the research. The findings
of this study provide important insights for developing synthetic AMPs as effective antimicrobial
drugs.
Non-Bacterial Thrombotic Endocarditis in Lung Cancer: A Systematic Review
Authors: Kamel Maikel , Hussain Fahad , Leung Christian , Paracha Awais , Sathe Pranav , Jassal Ajay , Huba Mahalia , Durrani Umar , Ammari Nadim , Copeland-Halperin Robert S. , Seetharamu Nagashree
Published: February 2025

Introduction:

Nonbacterial Thrombotic Endocarditis (NBTE) is a rare condition
characterized by aseptic vegetations of the heart valves, predisposing to valvular dysfunction
and end-organ infarction. Lung Cancer (LC) is amongst the most common malignancies associated
with NBTE.

Methods:

PubMed/MEDLINE was searched from database inception until January 2024, pairing
“Non-Bacterial Thrombotic Endocarditis (NBTE) and related terms with “Lung Cancer”(
LC). Reports were included if patients had both NBTE and lung cancer. The risk of bias
was assessed using Mixed Methods Analysis Testing (MMAT).

Results:

32 patients with an average age of 59y +/- 11.6 were included from 31 peer-reviewed
publications, with significant findings as below:
• The majority (47%) of patients were admitted with stroke.
• The most commonly affected valve was aortic (51%), followed by mitral (43%), and
tricuspid (5%).
• At diagnosis of NBTE, 86% of patients had stage IV cancer.
• Multi-organ infarct was common (61%), with the brain most often affected (40%).
• Treatment of NBTE included antibiotics (86%), anticoagulation (50%), and cardiac
surgery (6%).
• Treatment of LC included traditional chemotherapy (30.7%), radiation (16%), tyrosine
kinase inhibitors (11.5%), lobectomy (6%), and immunotherapy (3.8%).
• Overall mortality rate was 77%.
• Mortality rate was 38% in patients treated with chemotherapy and 91% in patients who
did not receive chemotherapy.
• Mortality rate stratified by anticoagulant: unfractionated heparin (85.7%), DOAC
(75%), and LMWH (20%).

Conclusion:

High clinical suspicion for NBTE in patients presenting with LC and thromboembolic
phenomena can lead to changes in treatment and improved clinical outcomes.
Plants as Medicine for Autism: Reviewing the Evidence for Phytopharmaceuticals for ASD
Authors: Al Noman Abdullah , Flora Sanzida Alam , Deb Tonni Susmita , Barua Cinmoy , Kumar Nath Anik , Bristy Kaniz Fatema , Ahmad Iftakhar , Pathak Rashmi , Sharma Himanshu
Published: February 2025

A complicated neural developmental condition, autism spectrum disorder (ASD) is
marked by difficulties with social interaction, communication, and repetitive behaviours. There is
increasing interest in complementary and alternative medicines, including medicinal plants, to
treat the symptoms of ASD as incidence rates rise globally. This thorough analysis looks at the
available data supporting a range of plant-based ASD control strategies. We assess important
therapeutic herbs, including Curcuma longa (turmeric), Bacopa monnieri, Ginkgo biloba, Cannabis
sativa, and Camellia sinensis (green tea), and talk about their bioactive components, possible
modes of action, and clinical results. Several plants have neuroprotective, anti-inflammatory, and
antioxidant qualities that may work against the underlying pathophysiological mechanisms of
ASD. The body of data is still small, even if certain clinical studies yield encouraging results,
especially in the areas of behaviour modification and symptom treatment. The diverse character
of ASD, small sample sizes, and methodological problems are study challenges. We also talk
about the restrictions and security issues surrounding herbal remedies. Potential directions for
phytopharmaceutical design for ASD in the future, such as combination therapy, enhanced delivery
strategies, and the requirement for more extensive, carefully planned clinical studies. The potential
of medicinal plants in treating ASD is highlighted in this review, but it also emphasizes the
urgent need for further thorough study to confirm their efficacy and safety.
A Potential Regulatory Network of Selected Human Erythrocytic miRNAs with Plasmodium falciparum 3D7 mRNAs: A Computational Analysis
Authors: Joshi Urja , Motwani Harsha , Jani Dhara , George Linz-buoy , Highland Hyacinth
Published: February 2025

Background:

miRNAs are small non-coding conserved RNA molecules (18-24 nts) that act as crucial gene regulators via post-transcriptional/translational modifications through in-teracting with the respective mRNAs during various pathophysiological conditions. Recent re-search has suggested that non-coding RNAs, particularly miRNAs, can be passed from one spe-cies to another to regulate gene expression. Since miRNA-mediated gene regulation has not yet been found in Plasmodia, it is hypothesized that erythrocytic miRNAs from Plasmodium falcipa-rum (P. falciparum) could potentially migrate from the cytoplasm to the parasitophorous vacuole developed intracellularly by the parasite to regulate its transcriptome.

Objective:

The objective of this study is to investigate the role of trans-kingdom interactions in host-parasite dynamics and their implications for malaria infection.

Methods:

Using the trans-kingdom target gene prediction tool, psRNA target server, a total of 15 human erythrocytic miRNAs from 12 distinct families were selected and obtained from miRBase to find potential P. falciparum candidate genes. This study utilized ShinyGO (version 0.80) for gene enrichment analysis with statistical analysis of the selected features. The PPI-network analysis was performed using the Maximal Clique Centrality (MCC) approach, along with the CytoHubba plugin for identifying hub nodes. The PPI network was visualized using Cytoscape version 3.7.

Results:

A total of 145 target genes of Pf3D7 were predicted, with the following genes repeatedly targeted: conserved Plasmodium proteins, conserved Plasmodium membrane proteins, PfEMP1, rifin, RAD54, E3 ubiquitin-protein ligase, and transcription factors related genes. Outputs of ShinyGO included enriched GO pathways of 62 uniquely identified Pf3D7 genes with detailed descriptions and visualized networks. For overlapping relationships, a hierarchical clustering tree of enriched gene sets was carried out, along with a genome plot for representing the chromosomal locations of these genes. According to their coding-noncoding distribution chart, most of these genes were found to be members of the coding gene family. Additionally, PPI-network analysis reported the top 10 hub nodes: PFE0400w, MAL13P1.380, MAL7P1.167, PFD0900w, PF11_0243, PFE0440w, PFE1120w, MAL13P1.315, PF08_0126, and MAL8P1.23. Three KEGG pathway diagrams of pfa 05144 for Malaria, pfa 03440 for homologous recombination, and pfa 00750 for vitamin B6 metabolism with identified Pf3D7 genes were drawn and high-lighted in red.

Conclusion:

The important target genes of Plasmodium falciparum 3D7 were identified by car-rying out a trans-kingdom investigation, thus offering preliminary insights into the potential of erythrocytic miRNAs-mediated trans-kingdom regulation.
Informing organizational strategies for digital public health: A qualitative description of practitioners’ perspectives on opportunities and challenges in a provincial public health organization in Canada (Preprint)
Authors: Iyamu Ihoghosa , Haag Devon , Carson Anna , Wang Ivy , King Colin , Roe Ian , Kerr Kristy , McKee Geoffrey , Gilbert Mark
Published: February 2025

BACKGROUND

The digital transformation of health services accelerated during the pandemic. While “digital health” strategies were created, they paid minimal attention to public health services like health promotion, disease surveillance, emergency preparedness, and health protection.

OBJECTIVE

To inform a digital public health (DPH) strategy at the BC Centre for Disease Control (BCCDC), we explored public health practitioners’ perspectives on challenges and opportunities of integrating digital technologies into public health functions within the organization.

METHODS

In this qualitative description, we conducted 18 focus groups (FGs) between January and June 2023, drawing practitioners from nine organizational subunits of the BCCDC including population and public health, environmental health, clinical services, vaccine preventable diseases, communications, knowledge translation, data analytics and Indigenous health (2 FGs per subunit). Discussions explored practitioners’ application of digital technologies in their public health work, focusing on challenges encountered during implementation (current state FGs) and perceived opportunities (future state FGs). Sessions were audio-recorded, and detailed field notes were taken. Thematic analysis was conducted, comparing perspectives across groups using constant comparative techniques.

RESULTS

We identified three themes. First, “bridging existing inequities - an opportunity and a challenge contingent on public trust” described participants’ excitement about opportunities for DPH to disrupt historical inequities if centred on trust and reconciliation, while recognizing current digital transformation efforts risk exacerbating existing inequities with the digital divide. Second “a sense of disconnect between “digital” and “public health” functions” described perceptions of DPH as being out of scope of core public health duties, requiring new competencies and navigation of complex organizational policies for which support is suboptimal. Third, “balancing the need for responsive DPH with necessary reactivity” highlighted practitioners’ yearnings for a proactive DPH strategy rather than current issue-based reactive approaches. Participants suggest a centralized systematic program can help achieve this goal.

CONCLUSIONS

A cohesive, systematic, and proactive organizational strategy for DPH is critical to enable equity-focused digital transformation. Such a strategy can bridge perceived disconnects between digital and public health functions through organizational supports like competency development and streamlined policies can better support public health practitioners to integrate digital technologies into their work.

CLINICALTRIAL

N/A