bluuebunny/crossref_metadata_2025 huggingface dataset:
Perceived Facilitators and Barriers to Participating in a Combination Income-Generating HIV Risk-Reduction Intervention Among Adolescent Girls and Young Women in Nigeria: A Qualitative Study
Authors: Nwaozuru Ucheoma , Tijani Wakilat , Gbajabiamila Titi , Obiezu-Umeh Chisom , Uzoaru Florida , Ezechi Oliver , Musa Adesola Z. , Curley Jami , BeLue Rhonda , Iwelunmor Juliet
Published: December 2021

Background: Human immunodeficiency virus risk-reduction interventions that include income-generating activities are garnering attention as effective strategies to engage adolescent girls and young women (AGYW) toward HIV risk reduction. To sustain and promote the uptake of these interventions, researchers must understand factors that may encourage or present barriers to AGYW participation in such interventions. This study explores AGYW perceived barriers and facilitators to participation in a school-based combination income-generating HIV prevention intervention in Nigeria.

Methods: A convenience sample of AGYW who participated in a school-based combination income-generating HIV prevention intervention were recruited for the study. Data generated from focus group discussions (FGDs) (eight discussion groups comprising 10–12 participants) were analyzed by inductive thematic analysis.

Results: A total of 93 participants with a mean age of 15.04 years (SD = 0.89) participated in the FGDs. The study participants identified several facilitators and barriers to participation in the intervention. Three main themes that emerged as facilitators were: (1) involvement of young female facilitators in the delivery of intervention components, (2) opportunity for social interaction with peers during the intervention period, and (3) support and approval from school authorities. Two main themes were also identified as barriers: (1) sexual conservatism from society and parents and (2) challenges in sustaining a microenterprise.

Conclusions: Despite the perceived benefits and interest in participation in the intervention, the study participants outlined some challenges that may hinder participation in the intervention components. Addressing barriers, such as stigma associated with the discussion of sexual health-related topics, coupled with the promotion of facilitating factors, such as leveraging context-appropriate intervention delivery modalities, is important for enhancing the engagement of AGYW in HIV risk-reduction intervention. Our findings can guide future research and design of combination income-generating HIV prevention interventions for in-school AGYW in low-resource settings such as Nigeria.
Application of Soil Water Assessment Tool (SWAT) Model in Analyzing Nitrogen Transport Inside the Narmada River Basin
Authors: Kansara Prakrut , Lakshmi Venkataraman
Published: December 2021

The Narmada River is one of the largest rivers in Western India encompassing a watershed area of 92,672 km2. It is one of the most important rivers for water needs of the state of Gujarat, Maharashtra, and Madhya Pradesh. The climate of the basin is humid and tropical but region surrounding this river watershed is predominantly dry and resembles semi-arid conditions. The population inside the states covering this watershed increased by an average of 23% from 1991 to 2011 causing multitude of water scarcity and water quality deterioration issues. These problems were caused by increase in sewage waste and untreated industrial discharge dumped into the river stream along with chemical fertilizers washing off from the farmlands flowing into the river. While there are several studies that model the watershed hydrology and water balance components, there has been no study that analyses the transport of nutrients inside the watershed. This study aims at using a semi-distributed hydrological model—Soil Water Assessment Tool (SWAT) to model the nitrogen (NO2 + NO3) transport and distribution inside the basin for 2001–2019. Nutrients and discharge data from Central Water Commission (CWC) of India were used to build this model along with other required input forcing obtained through remotely sensed datasets. We found that the subbasins near boundary of the Narmada watershed are experiencing significant increase in nitrogen concentrations at an estimated rate of 0.0001–0.002 mg/L/yr. The potential reason for such increase is high rate of conversion of forested land to agricultural land causing usage of fertilizers that are rich in nitrogen.
The Kelvin-Helmholtz Instability From the Perspective of Hybrid Simulations
Authors: Delamere P. A. , Barnes N. P. , Ma X. , Johnson J. R.
Published: December 2021

The flow shear-driven Kelvin-Helmholtz (KH) instability is ubiquitous in planetary magnetospheres. At Earth these surface waves are important along the dawn and dusk flanks of the magnetopause boundary while at Jupiter and Saturn the entire dayside magnetopause boundary can exhibit KH activity due to corotational flows in the magnetosphere. Kelvin-Helmholtz waves can be a major ingredient in the so-called viscous-like interaction with the solar wind. In this paper, we review the KH instability from the perspective of hybrid (kinetic ions, fluid electrons) simulations. Many of the simulations are based on parameters typically found at Saturn’s magnetopause boundary, but the results can be generally applied to any KH-unstable situation. The focus of the discussion is on the ion kinetic scale and implications for mass, momentum, and energy transport at the magnetopause boundary.
Dangerous Behavior and Intractable Axial Skeletal Pain in Performance Horses: A Possible Role for Ganglioneuritis (14 Cases; 2014–2019)
Authors: Story Melinda R. , Nout-Lomas Yvette S. , Aboellail Tawfik A. , Selberg Kurt T. , Barrett Myra F. , Mcllwraith C. Wayne , Haussler Kevin K.
Published: December 2021

Introduction: Dangerous behavior is considered an undesired trait, often attributed to poor training or bad-tempered horses. Unfortunately, horses with progressive signs of dangerous behavior are often euthanized due to concerns for rider safety and limitations in performance. However, this dangerous behavior may actually originate from chronic axial skeleton pain. This case series describes the medical histories and clinical presentations of horses presented for performance limitations and dangerous behavior judged to be related to intractable axial skeleton pain.

Material and Methods: Fourteen horses that developed severe performance limitations resulting in euthanasia were included. A complete spinal examination and behavioral responses, gait and neurologic evaluations, diagnostic imaging, gross pathologic and histopathologic examinations of the axial skeleton were performed on all horses. A tentative diagnosis of the affected spinal region was formulated using medical records, owner and trainer complaints, and antemortem examination findings. The selected spinal regions were further examined with gross and histopathologic evaluations of the associated osseous, soft tissue and neural tissues.

Results: Ten horses showed severe behavioral responses during the myofascial and mobilization examinations. Based on an aggregate evaluation, the cervicothoracic and lumbosacral regions were the most common regions believed to be the primary area of concern. All horses had moderate to severe ganglionitis present at multiple vertebral levels. Subdural and epidural hemorrhage or hematomas were a common finding (71%) in the cervicothoracic and lumbosacral regions.

Discussion: In this case series, neuropathic (i.e., structural) pain was judged to be the underlying cause of dangerous behavior. The dorsal root ganglia (DRG) serve an important role in relaying peripheral sensory information to the central nervous system and ganglionitis has been associated with neuropathic pain syndromes. This series highlights the need for more in-depth understanding of pain behavior and its clinical presentation and progression in chronic or severely affected horses. Limitations of the study are the lack of age-matched control DRG and the incomplete collection of DRG from every vertebral level of interest.
Kill Rate and Evaluation of Ex Vivo PK/PD Integration of Cefquinome Against Actinobacillus pleuropneumoniae
Authors: Zhang Longfei , Xie Hongbing , Wang Hongjuan , Ding Huanzhong , Zhang Gaiping , Hu Jianhe
Published: December 2021

We wished to study the detailed and precise antibacterial activity of cefquinome against Actinobacillus pleuropneumoniae (APP) in vitro and ex vivo. We analyzed the relationships between kill rate and cefquinome concentration in broth and between pharmacokinetic/pharmacodynamic (PK/PD) parameters and antibacterial effect in serum and tissue cage fluid (TCF) of piglets. Cefquinome exhibited time-dependent antibacterial activity against APP according to the kill rate. The maximum kill rate was 0.48 log10 CFU/mL/h at the 0-9-h period in broth. In the ex vivo PK/PD study, the maximum concentration (Cmax), time to reach the maximum concentration (Tmax), terminal half-life (T1/2β), and area under the concentration time curve (AUCinfinity) were 5.65 μg/ml, 0.58 h, 2.24 h, and 18.48 μg·h/ml in serum and 1.13 μg/ml, 2.60 h, 12.22 h, and 20.83 μg·h/ml in TCF, respectively. The values of area under the curve during 24 h/minimum inhibitory concentration (AUC24h/MIC) for bacteriostatic, bactericidal, and bacterial eradication effects were 18.94, 246.8, and 1013.23 h in serum and 4.20, 65.81, and 391.35 h in TCF, respectively. Our findings will provide a valuable basis for optimization of dosage regimens when applying cefquinome to treat APP infection.
Where Are We on the Animal Welfare Map? Using GIS to Assess Stakeholder Diversity and Inclusion
Authors: Roberts Kevin C. , Buckingham Tegan L. , Janke Kyrsten J. , Jacobson Linda S.
Published: December 2021

Inequities exist in all facets of society, and animal welfare organizations (AWOs) and their communities are no exception. These organizations interface with multiple stakeholder groups. An active analysis of stakeholder groups to identify under-served areas and communities has not been performed. Using stakeholder data from Toronto Humane Society (THS) from 2015–2019, this study performed a retrospective spatial analysis to identify well served and under-served geographic areas for adopters, surrenders, public veterinary service (PVS) clients, volunteers and foster parents, using Hot Spot analysis. Correlation analysis was performed to determine whether the spatial distribution of the groups correlated with the four socioeconomic metrics of the 2016 Ontario Marginalization Index (residential instability, material deprivation, dependency, and ethnic concentration), and a metric representing the distribution of Indigenous residents. For each stakeholder group, there were well served areas, typically in central Toronto where THS is located, and under-served areas, typically in the north-west and north-east corners of Toronto and in the surrounding cities of the Greater Toronto Area. The area served by THS PVS extended further north than the other hot spot areas. The number of adopters increased as the residential instability metric increased, whereas the number of adopters decreased as the ethnic concentration metric increased. The rate of surrenders increased as the Indigenous metric increased. Public Veterinary Service clients increased as the residential instability, material deprivation, and Indigenous metrics increased. One of the primary limitations of this study was the confounding factor of distance from THS. Individuals living further from THS are less likely to utilize its services, particularly if there is another accessible AWO nearby, and therefore may appear to reflect an under-served population that may not truly be under-served. A regional approach would help to overcome this limitation. The results provide useful insights into stakeholder engagement and provide a foundation for analysis of more targeted areas, as well as for strategies to reach under-served demographics. Similar analyses by other AWOs would be helpful to address inequities in a larger geographic area. Animal welfare organizations can improve program effectiveness by adding data analytics skills to the more traditional skills associated with this sector.
Optimized Weighted Nearest Neighbours Matching Algorithm for Control Group Selection
Authors: Szekér Szabolcs , Vathy-Fogarassy Ágnes
Published: December 2021

An essential criterion for the proper implementation of case-control studies is selecting appropriate case and control groups. In this article, a new simulated annealing-based control group selection method is proposed, which solves the problem of selecting individuals in the control group as a distance optimization task. The proposed algorithm pairs the individuals in the n-dimensional feature space by minimizing the weighted distances between them. The weights of the dimensions are based on the odds ratios calculated from the logistic regression model fitted on the variables describing the probability of membership of the treated group. For finding the optimal pairing of the individuals, simulated annealing is utilized. The effectiveness of the newly proposed Weighted Nearest Neighbours Control Group Selection with Simulated Annealing (WNNSA) algorithm is presented by two Monte Carlo studies. Results show that the WNNSA method can outperform the widely applied greedy propensity score matching method in feature spaces where only a few covariates characterize individuals and the covariates can only take a few values.
Factorized One-Way Wave Equations
Authors: Bschorr Oskar , Raida Hans-Joachim
Published: December 2021

The method used to factorize the longitudinal wave equation has been known for many decades. Using this knowledge, the classical 2nd-order partial differential Equation (PDE) established by Cauchy has been split into two 1st-order PDEs, in alignment with D’Alemberts’s theory, to create forward- and backward-traveling wave results. Therefore, the Cauchy equation has to be regarded as a two-way wave equation, whose inherent directional ambiguity leads to irregular phantom effects in the numerical finite element (FE) and finite difference (FD) calculations. For seismic applications, a huge number of methods have been developed to reduce these disturbances, but none of these attempts have prevailed to date. However, a priori factorization of the longitudinal wave equation for inhomogeneous media eliminates the above-mentioned ambiguity, and the resulting one-way equations provide the definition of the wave propagation direction by the geometric position of the transmitter and receiver.
Experimental and CFD Characterization of a Double-Orifice Synthetic Jet Actuator for Flow Control
Authors: Palumbo Andrea , de Luca Luigi
Published: December 2021

The paper presents a joint experimental and numerical characterization of double-orifice synthetic jet actuators for flow control. Hot-wire measurements of the flow field generated by the device into a quiescent air environment were collected. The actuation frequency was systematically varied to obtain the frequency response of the actuator; its coupled resonance frequencies were detected and the velocity amplitude was measured. Direct numerical simulations (DNS) of the flow field generated by the device were subsequently carried out at the actuation frequency maximizing the jet output. The results of a fine-meshed parametric analysis are outlined to discuss the effect of the distance between the orifices: time-averaged flow fields show that an intense jet interaction occurs for small values of the orifice spacing-to-diameter ratio; phase-averaged velocity and turbulent kinetic energy distributions allow to describe the vortex motion and merging. A novel classification of the main regions of dual synthetic jets is proposed, based on the time- and phase-averaged flow behaviour both in the near field, where two distinct jets converge, and in the far field, where an unique jet is detected. The use of three-dimensional DNS also allows to investigate the vortex merging for low values of the jet spacing. The work is intended to provide guidelines for the design of synthetic jet arrays for separation control and impinging configurations.
Design of a High Uniformity Laser Sheet Optical System for Particle Image Velocimetry
Authors: Yin Kewei , Zhang Jun , Chen Shuang
Published: December 2021

Particle image velocimetry (PIV) is a non-contact, instantaneous and full-flow velocity measurement method based on cross-correlation analysis of particle image. It is widely used in fluid mechanics and aerodynamics. Laser sheet optical system is one of the key equipment of PIV, and it is an important guarantee to obtain high definition particle image. In the PIV measurement task of large low speed wind tunnel, in order to solve the problem of sheet light illumination uniformity of large size model and take into account the requirements of PIV technology on the thickness of the sheet light, a hybrid algorithm is used to design a high uniformity laser sheet optical system based on the theory of physical optics. The simulation results show that the size of the sheet light is 400 mm × 1 mm, the diffraction efficiency reaches 97.77%, and the non-uniformity is only 0.03%. It is helpful to acquire high-resolution images of particles in the full field of view. It also can be applied to a series of non-contact flow field measurement techniques such as plane laser induced fluorescence, filtered Rayleigh scattering and two-color plane laser induced fluorescence temperature measurement.
Delafloxacin, Finafloxacin, and Zabofloxacin: Novel Fluoroquinolones in the Antibiotic Pipeline
Authors: Kocsis Béla , Gulyás Dániel , Szabó Dóra
Published: December 2021

Novel antimicrobial agents, approved for clinical use in past years, represent potential treatment options for various infections. In this review, we summarize the most important medical and microbiological features of three recently approved fluoroquinolones, namely delafloxacin, finafloxacin, and zabofloxacin. Delafloxacin possesses an anionic chemical structure, and represents broad-spectrum activity, as it targets both bacterial DNA gyrase and topoisomerase IV enzymes of gram-positive and gram-negative bacteria with equal affinity. Its molecular surface is larger than that of other fluoroquinolones, and it has enhanced antibacterial efficacy in acidic environments. Delafloxacin has been approved to treat acute bacterial skin and skin-structure infections, as well as community-acquired bacterial pneumonia. Finafloxacin has a zwitterionic chemical structure, and targets both DNA gyrase and topoisomerase IV enzymes. This enables a broad antibacterial spectrum; however, finafloxacin has so far only been approved in ear-drops to treat bacterial otitis externa. Zabofloxacin is also a broad-spectrum fluoroquinolone agent, and was first approved in South Korea to treat acute bacterial exacerbation of chronic obstructive pulmonary disease. The introduction of these novel fluoroquinolones into daily practice extends the possible indications of antibiotics into different bacterial infections, and provides treatment options in difficult-to-treat infections. However, some reports of delafloxacin resistance have already appeared, thus underlining the importance of the prudent use of antibiotics.
Global Prevalence of Nosocomial Multidrug-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis
Authors: Mohd Asri Nur Ain , Ahmad Suhana , Mohamud Rohimah , Mohd Hanafi Nurmardhiah , Mohd Zaidi Nur Fatihah , Irekeola Ahmad Adebayo , Shueb Rafidah Hanim , Yee Leow Chiuan , Mohd Noor Norhayati , Mustafa Fatin Hamimi , Yean Chan Yean , Yusof Nik Yusnoraini
Published: December 2021

The emergence of nosocomial multidrug-resistant Klebsiella pneumoniae is an escalating public health threat worldwide. The prevalence of nosocomial infections due to K. pneumoniae was recorded up to 10%. In this systematic review and meta-analysis, which were conducted according to the guidelines of Preferred Reporting Items for Systematic Review and Meta-Analysis, 1092 articles were screened from four databases of which 47 studies fulfilled the selected criteria. By performing a random-effect model, the pooled prevalence of nosocomial multidrug-resistant K. pneumoniae was estimated at 32.8% (95% CI, 23.6–43.6), with high heterogeneity (I2 98.29%, p-value < 0.001). The estimated prevalence of this pathogen and a few related studies were discussed, raising awareness of the spread of multidrug-resistant K. pneumoniae in the healthcare setting. The emergence of nosocomial multidrug-resistant K. pneumoniae is expected to increase globally in the future, and the best treatments for treating and preventing this pathogen should be acknowledged by healthcare staff.
Real Life Clinical Impact of Antimicrobial Stewardship Actions on the Blood Culture Workflow from a Microbiology Laboratory
Authors: López-Pintor Jose Maria , Sánchez-López Javier , Navarro-San Francisco Carolina , Sánchez-Díaz Ana Maria , Loza Elena , Cantón Rafael
Published: December 2021

Background: Accelerating the diagnosis of bacteremia is one of the biggest challenges in clinical microbiology departments. The fast establishment of a correct treatment is determinant on bacteremic patients’ outcomes. Our objective was to evaluate the impact of antimicrobial therapy and clinical outcomes of a rapid blood culture workflow protocol in positive blood cultures with Gram-negative bacilli (GNB). Methods: A quasi-experimental before–after study was performed with two groups: (i) control group (conventional work-protocol) and (ii) intervention group (rapid workflow-protocol: rapid identification by Matrix-Assisted Laser Desorption/Ionization-Time-Of-Flight (MALDI-TOF) and antimicrobial susceptibility testing (AST) from bacterial pellet without overnight incubation). Patients were divided into different categories according to the type of intervention over treatment. Outcomes were compared between both groups. Results: A total of 313 patients with GNB-bacteremia were included: 125 patients in the control group and 188 in the intervention. The time from positive blood culture to intervention on antibiotic treatment decreased from 2.0 days in the control group to 1.0 in the intervention group (p < 0.001). On the maintenance of correct empirical treatment, the control group reported 2.0 median days until the clinical decision, while in the intervention group was 1.0 (p < 0.001). In the case of treatment de-escalation, a significant difference between both groups (4.0 vs. 2.0, p < 0.001) was found. A decreasing trend on the change from inappropriate treatments to appropriate ones was observed: 3.5 vs. 1.5; p = 0.12. No significant differences were found between both groups on 7-days mortality or on readmissions in the first 30-days. Conclusions: Routine implementation of a rapid workflow protocol anticipates the report of antimicrobial susceptibility testing results in patients with GNB-bacteremia, decreasing the time to effective and optimal antibiotic therapy.
Chemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissa
Authors: El Mehdi Iouraouine , Falcão Soraia I. , Harandou Mustapha , Boujraf Saïd , Calhelha Ricardo C. , Ferreira Isabel C. F. R. , Anjos Ofélia , Campos Maria G. , Vilas-Boas Miguel
Published: December 2021

The venom from Apis mellifera intermissa, the main honey bee prevailing in Morocco, has been scarcely studied, despite its known potential for pharmacological applications. In the present work, we investigated the composition, the anti-inflammatory activity, and the venom’s cytotoxic properties from fifteen honey bee venom (HBV) samples collected in three regions: northeast, central, and southern Morocco. The chemical assessment of honey bee venom was performed using LC-DAD/ESI/MSn, NIR spectroscopy and AAS spectroscopy. The antiproliferative effect was evaluated using human tumor cell lines, including breast adenocarcinoma, non-small cell lung carcinoma, cervical carcinoma, hepatocellular carcinoma, and malignant melanoma. Likewise, we assessed the anti-inflammatory activity using the murine macrophage cell line. The study provides information on the honey bee venom subspecies’ main components, such as melittin, apamin, and phospholipase A2, with compositional variation depending on the region of collection. Contents of toxic elements such as cadmium, chromium, and plumb were detected at a concentration below 5 ppm, which can be regarded as safe for pharmaceutical use. The data presented contribute to the first study in HBV from Apis mellifera intermissa and highlight the remarkable antiproliferative and anti-inflammatory effects of HBV, suggesting it to be a candidate natural medicine to explore.
Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
Authors: Teixeira-Gomes Armanda , Laffon Blanca , Valdiglesias Vanessa , Gostner Johanna M. , Felder Thomas , Costa Carla , Madureira Joana , Fuchs Dietmar , Teixeira João Paulo , Costa Solange
Published: December 2021

Ageing is accompanied with a decline in several physiological systems. Frailty is an age-related syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalisation, and death in older adults. The aim of this study was to understand the relationship between frailty syndrome, immune activation, and oxidative stress. Serum concentrations of vitamins A and E were also evaluated, as well as inflammatory biomarkers (CRP and IL-6) and oxidative DNA levels. A group of Portuguese older adults (≥65 years old) was engaged in this study and classified according to Fried’s frailty phenotype. Significant increases in the inflammatory mediators (CRP and IL-6), neopterin levels, kynurenine to tryptophan ratio (Kyn/Trp), and phenylalanine to tyrosine ratio (Phe/Tyr), and significant decreases in Trp and Tyr concentrations were observed in the presence of frailty. IL-6, neopterin, and Kyn/Trp showed potential as predictable biomarkers of frailty syndrome. Several clinical parameters such as nutrition, dependency scales, and polypharmacy were related to frailty and, consequently, may influence the associations observed. Results obtained show a progressive immune activation and production of pro-inflammatory molecules in the presence of frailty, agreeing with the inflammageing model. Future research should include different dimensions of frailty, including psychological, social, biological, and environmental factors.
On the Subrange and Its Application to the R-Chart
Authors: Xie En , Ma Yizhong , Ouyang Linhan , Park Chanseok
Published: December 2021

The conventional sample range is widely used for the construction of an R-chart. In an R-chart, the sample range estimates the standard deviation, especially in the case of a small sample size. It is well known that the performance of the sample range degrades in the case of a large sample size. In this paper, we investigate the sample subrange as an alternative to the range. This subrange includes the range as a special case. We recognize that we can improve the performance of estimating the standard deviation by using the subrange, especially in the case of a large sample size. Note that the original sample range is biased. Thus, the correction factor is used to make it unbiased. Likewise, the original subrange is also biased. In this paper, we provide the correction factor for the subrange. To compare the sample subranges with different trims to the conventional sample range or the sample standard deviation, we provide the theoretical relative efficiency and its values, which can be used to select the best trim of the subrange with the sense of maximizing the relative efficiency. For a practical guideline, we also provide a simple formula for the best trim amount, which is obtained by the least-squares method. It is worth noting that the breakdown point of the conventional sample range is always zero, while that of the sample subrange increases proportionally to a trim amount. As an application of the proposed method, we illustrate how to incorporate it into the construction of the R-chart.
Efficient Detection of DDoS Attacks Using a Hybrid Deep Learning Model with Improved Feature Selection
Authors: Alghazzawi Daniyal , Bamasag Omaimah , Ullah Hayat , Asghar Muhammad Zubair
Published: December 2021

DDoS (Distributed Denial of Service) attacks have now become a serious risk to the integrity and confidentiality of computer networks and systems, which are essential assets in today’s world. Detecting DDoS attacks is a difficult task that must be accomplished before any mitigation strategies can be used. The identification of DDoS attacks has already been successfully implemented using machine learning/deep learning (ML/DL). However, due to an inherent limitation of ML/DL frameworks—so-called optimal feature selection—complete accomplishment is likewise out of reach. This is a case in which a machine learning/deep learning-based system does not produce promising results for identifying DDoS attacks. At the moment, existing research on forecasting DDoS attacks has yielded a variety of unexpected predictions utilising machine learning (ML) classifiers and conventional approaches for feature encoding. These previous efforts also made use of deep neural networks to extract features without having to maintain the track of the sequence information. The current work suggests predicting DDoS attacks using a hybrid deep learning (DL) model, namely a CNN with BiLSTM (bidirectional long/short-term memory), in order to effectively anticipate DDoS attacks using benchmark data. By ranking and choosing features that scored the highest in the provided data set, only the most pertinent features were picked. Experiment findings demonstrate that the proposed CNN-BI-LSTM attained an accuracy of up to 94.52 percent using the data set CIC-DDoS2019 during training, testing, and validation.
New van der Waals Heterostructures Based on Borophene and Rhenium Sulfide/Selenide for Photovoltaics: An Ab Initio Study
Authors: Slepchenkov Michael M. , Kolosov Dmitry A. , Glukhova Olga E.
Published: December 2021

One of the urgent tasks of modern materials science is the search for new materials with improved optoelectronic properties for various applications of optoelectronics and photovoltaics. In this paper, using ab initio methods, we investigate the possibility of forming new types of van der Waals heterostructures based on monolayers of triangulated borophene, and monolayers of rhenium sulfide (ReS), and rhenium selenide (ReSe2), and predict their optoelectronic properties. Energy stable atomic configurations of borophene/ReS2 and borophene/ReSe2 van der Waals heterostructures were obtained using density functional theory (DFT) calculations in the Siesta software package. The results of calculating the density of electronic states of the obtained supercells showed that the proposed types of heterostructures are characterized by a metallic type of conductivity. Based on the calculated optical absorption and photocurrent spectra in the wavelength range of 200 to 2000 nm, it is found that borophene/ReS2 and borophene/ReSe2 heterostructures demonstrate a high absorption coefficient in the near- and far-UV(ultraviolet) ranges, as well as the presence of high-intensity photocurrent peaks in the visible range of electromagnetic radiation. Based on the obtained data of ab initio calculations, it is predicted that the proposed borophene/ReS2 and borophene/ReSe2 heterostructures can be promising materials for UV detectors and photosensitive materials for generating charge carriers upon absorption of light.
The Formation of Nanoscale Closed Graphene Surfaces during Fullerite C60 Hot Isostatic Pressing
Authors: Sivkov Danil V. , Petrova Olga V. , Nekipelov Sergey V. , Vinogradov Alexander S. , Skandakov Roman N. , Bakina Ksenia A. , Isaenko Sergey I. , Ob’edkov Anatoly M. , Kaverin Boris S. , Sivkov Viktor N.
Published: December 2021

The fullerite C60 modified by hot isostatic pressing (HIP) at 0.1 GPa in argon near and beyond its thermal stability region (920–1270 K temperature interval) was studied by X-ray diffractometry, Raman spectroscopy, ultra soft X-ray photoelectron and near edge X-ray absorption fine structure spectroscopy. It was found that the C60 molecules merge into closed nanocapsules with a graphene surface during the thermal treatment. The conducted studies showed that using HIP treatment of the fullerite C60, it is possible to obtain a chemically resistant material with a high hardness and elasticity, as well as a density lower than that of the graphite. This new material, consisting of closed graphene nanocapsules 2–5 nm in size, formed by sp2 covalent bonds between carbon atoms is promising for various applications, and as a basis for the synthesis of new composite materials.
Older Adults’ Experience of an Exergaming Intervention to Improve Balance and Prevent Falls: A Nested Explanatory Qualitative Study
Authors: Rogers Christine , Shamley Delva , Amosun Seyi
Published: December 2021

Falls are frequent and life-changing events for older adults worldwide. The ageing phenomenon has arrived in developing countries, which experience tensions between curative and rehabilitative services, combined with an increase in non-communicable diseases. Policies addressing issues of ageing have been poorly implemented, and there are few fall prevention initiatives. Compelling evidence from the Global North supports exercise-based interventions to improve balance and reduce fall risk in older adults. More recently, attention has focused on interactive videogaming, known as exergames, as a novel way to manage fall risk with exercise. Commercially available exergames have inherent appeal for low- and middle-income country contexts, where rehabilitation professionals and resources are scanty. The aim of this study was to explore the feasibility of a large-scale randomized control trial comparing an exergaming intervention with the gold-standard Otago Exercise Programme and a no-intervention arm. Exercise adherence was poor in both intervention arms, and this prompted a shift to mixed methodology to explore the construct of falls and participants’ experience of the exergaming intervention. Focus groups were conducted, and the results were analysed using content analysis. Whereas the results demonstrated improvements in physical outcome measures (e.g., Timed-Up-and-Go, MiniBESTest) related to balance and falls that were encouraging in both the gold-standard and exergaming intervention groups, few participants achieved optimal adherence. Attitudes toward falls and fall prevention were explored, as well as participants’ experiences of the exergaming programme. Consistent with a developing country context, participants acknowledged both intrinsic and extrinsic fall risk factors. Exergaming participants enjoyed the fun and playful aspects of the exercise programme, yet these were not sufficient to maximize adherence. The focus groups described the barriers and facilitators to participation, which included motivation. The focus groups discussed strategies to enhance participation, and these are discussed in the context of exergaming.
Design and In Vivo Evaluation of a Novel Transdermal Hydrogen/Oxygen-Generating Patch
Authors: Ho Wen-Tsung , Yu Tsung-Hsun , Chao Wen-Hung , Wang Bao-Yen , Kuo Yu-Yeh , Lin Ming-Hsien , Yeh Skye Hsin-Hsien
Published: December 2021

Hydrogen/oxygen-generating biomaterials, a new trend in regenerative medicine, generate and supply hydrogen/oxygen to increase the local levels of hydrogen/oxygen to support tissue healing and regeneration. In this study, we carefully defined a strategic plan to develop a gas-permeable layer suitable for use in sanitary products that is capable of supplying hydrogen or oxygen in situ using calcium hydroxides as chemical oxygen sources. In vitro physicochemical evaluations of hydrogen- and oxygen-generation efficiency were performed to determine the amount of hydrogen and oxygen produced. An in vivo permeation study was conducted to assess biological parameters, including blood oxygen (O2) and hydrogen (H+) levels. The stress hormone corticosterone and inflammation marker interleukin 6 (IL-6) were also quantified. The hydrogen/oxygen-generating patch (HOGP) continuously generated H+ or O2 for up to 12 h after activation by water. An in vivo evaluation showed blood H+ peaked at 2 h after application of the HOGP and then progressively decreased until the end of study (24 h), whereas oxygen content (O2(ct)) and oxygen saturation (SO2(SAT)) continuously increased up to 6 h. Hematological and electrolyte parameters did not significantly change compared to baseline. Wearing the stretch fabric used to secure the patch did not significantly increase serum corticosterone or interleukin 6 (IL-6) in the animals. This novel design of a hydrogen/oxygen-generating biomaterial for supplying topical H+/O2 may hold potential for increasing in situ or circulating H+/O2 levels to improve healthcare outcomes.
Hydrochemical Indicators Analysis of Seawater Intrusion in Coastal Karstic Aquifers on the Example of the Bokanjac-Poličnik Catchment Area in Zadar, Croatia
Authors: Plantak Lucija , Biondić Ranko , Meaški Hrvoje , Težak Denis
Published: December 2021

Monitoring and detection of seawater intrusion in coastal aquifers in Croatia are one of the water management measures that attempt to notice an increase in salinity in time. Bokanjac-Poličnik is the coastal aquifer in Croatia that is at the risk of seawater intrusion. In that area, analysis of hydro-chemical indicators will be conducted due to the occasional seawater intrusion that occurs on wells that are included in the water supply system for the City of Zadar and surrounding villages. Due to the increased exploitation during the tourism season in summer and climate changes, salinization process is more intense. The presented results indicate that two of four wells on the case study area are under the influence of salt marine water.
Numerical Model Development of the Air Temperature Variation in a Room Set on Fire for Different Ventilation Scenarios
Authors: Lulea Marius Dorin , Iordache Vlad , Năstase Ilinca
Published: December 2021

Statistics show that most fires occur in civil residential buildings. Most casualties are due to the inhalation of hot air loaded with smoke, leading to intoxication with substances harmful to the human body. This research aimed to develop a CFD model that relates the operation of the sprinkler system to the operation of the ventilation system through the air temperature in a specific point close to the sprinkler position. A real-scale experiment was carried out, and a CDF model was developed. Several parameters of the CFD model (thermal conductivity of the experimental test room walls, numerical grid elements’ dimensions, burner heat release rate variation) were imposed to the model, so that the resulting entire time variation of the temperature next to the sprinkler location corresponds to the real measured variation. Two other experiments were used to validate the numerical model. Besides the air temperature, at this point, other essential parameters were determined in the entire experimental space: indoor air temperature, visibility, oxygen concentration, and carbon dioxide concentration. We found that if the ventilation rate increases, the indoor temperatures in that specific point decrease, and the sprinkler is activated later or, in some cases, it might never be activated. However, this conclusion is not valid for the entire analyzed space, as the ventilation system alongside the natural air movement imposes specific air speed and specific temperature distribution inside the analyzed space.
Static and Seismic Responses of Eco-Friendly Buried Concrete Pipes with Various Dosages of Fly Ash
Authors: Mostofizadeh Sayedali , Tee Kong Fah
Published: December 2021

In this paper, an evaluation based on the detailed failure has been conducted for underground sewage Geopolymer concrete (GPC) pipes under static and seismic loadings with consideration of the optimal time steps in the time-dependent process related to nonlinear behavior of GPC pipes in static and dynamic analyses. The ANSYS platform is employed for improving an advanced FE model for a GPC pipe which can simulate the performance of underground GPC pipes containing various percentages of fly ash (FA) as a Portland cement (PC) replacement. Subsequently, the time-dependent model is used to assess the efficacy of this concrete admixture (FA) in the structural response of the unreinforced GPC pipe in FEM. Indeed, the generated GPC pipe with the three-dimensional model has the potential to capture the nonlinear behavior of concrete which depicts the patterns of tensile cracking and compressive crushing that occur over the applied static loads in the FE model. The main issue in this paper is the assessment of the GPC pipe response typically based on the displacement due to static and seismic loadings. The numerical results demonstrated that the optimal displacement was obtained when the structural response had typically the lowest value for GPC pipes containing 10–30% FA and 20% FA under static and seismic loadings, respectively. Indeed, a reduction by 25% for the vertical displacement of a GPC pipe containing 20% FA was observed compared to that without FA under time-history analysis.
Screening of Xanthium strumarium (IAPS) Growing on Abandoned Habitats in Khyber Pakhtunkhwa, Pakistan: Perspectives for Phytoremediation
Authors: Ullah Rafi , Khan Nasrullah , Ali Kishwar , Khan Muhammad Ezaz Hasan , Jones David Aaron
Published: December 2021

The ecological impacts of invasive alien plant species (IAPS) are well-documented, but a dearth of studies exist concerning its economic, livelihood, biotechnological, and health risk assessment perspectives. IAPS management is currently expanding to ecological indicator and biotechnological aspects. Hence, this study aimed to investigate the phytoremediation potential, biomedical, and bio-safety applications of X. strumarium growing in different abandoned habitats in Khyber Pakhtunkhwa, Pakistan. In this study, 45 plants and soil samples were gathered from 15 abandoned sites and analyzed for Pb, Cd, Cu, and Zn concentrations; bioaccumulation (BA); and translocation factor (TF). The assayed Pb and Cd concentration was higher and above threshold in both soil–plant samples. BAF was found higher in roots than intact plants despite having a significant accumulation of Cd, Pb, and Zn, which shows high metals tolerance of this IAPS. PCA-ordination explained a high cumulative variance (98.9%) and separated roads and densely populated sites with comparatively high metals concentration, indicating the pseudometallophyte nature of X. strumarium. Soil, sand, and plant biomass were shown to be the major determinants affecting the heavy metals concentration and its phytoremediation significantly, which may be due to the soil’s metalliferous nature in the study area. This IAPS exhibited strong translocation and hyperaccumulation capacity in different functional traits with comparatively high Pb, Cd, and Zn (≥1 TF) mobility and, hence, can effectively be used for Pb phytoextraction and phytostabilization of Cd, Cu, and Zn, respectively. Likewise, several other non-spontaneous IAPS growing on such abandoned habitats might be promising for developing a reasonable strategic framework for heavy metals mitigation and health risk implications in this region.
Simplified Pushover Analysis for Rapid Assessment of Shear-Type Frames
Authors: Rahmat Rabi Raihan , Vailati Marco , Monti Giorgio
Published: December 2021

A simplified pushover method for rapidly assessing the seismic capacity of shear-type frames is presented. The frame global force-displacement capacity is described as a trilinear curve passing through three limit states (LS): Damage LS (DLS), Life safety LS (LLS), and Collapse LS (CLS). The global LSs are obtained consequently to the attainment of story-level, element-level, and section-level LSs. All LS capacities are described through closed-form equations. The validity of the proposed method is verified by applying it on several reinforced concrete (RC) frames with a varying number of stories. The results obtained with such an analytical procedure show a good match with those obtained from pushover based on finite element method (FEM) analysis models, in terms of both global force-displacement capacity curves and story displacements at various LSs. The proposed method has the potential to be conveniently applied in large-scale vulnerability/risk assessment studies, where the quality and quantity of the available data call for the use of simplified yet accurate models. More refined models would in fact require significantly heavier computational efforts, not justified by the quality of the results that are usually obtained. The simplicity of the proposed method in such a context is demonstrated through the development of the fragility curves of a five-story shear-type reinforced concrete frame, starting from a predefined set of mechanical and geometrical features characterizing a building typology.
Development of Dynamics for Design Procedure of Novel Grating Tiling Device with Experimental Validation
Authors: Bai Qingshun , Shehata Mohamed , Nada Ayman , Shao Zhongxi
Published: December 2021

The article proposes a dynamic for design (DFD) procedure for a novel aperture grating tiling device using the multibody system (MBS) approach. The grating device is considered as a rigid-flexible MBS that is built primarily based totally at the load assumptions because of grating movement. This movement is utilized in many industrial applications, such as the compression of laser pulse, precision measuring instruments, and optical communication. A new design procedure of tiling grating device frame is introduced in order to optimize its design parameters and enhance the system stability. The dynamic loads are estimated based on the Lagrange multipliers that are obtained from the solution of the MBS model. This model is fully non-linear and moves in the three-dimensional space, and the relative movement of its bodies is restricted by the description of the constraints function in the motion manifold. The mechanism of the grating device is structurally analyzed in keeping with the dynamic conduct and therefore the generated forces. The symbolic manipulation as well as the computational work of solving the obtained differential-algebraic equations (DAEs) is carried out using MATLAB Symbolic Toolbox. Once the preliminary design has been attained, the stress behavior of the grating device is examined using the MATLAB FEATool Multiphysics toolkit, regarding system stability and design aspects. Moreover, the design was constructed in real life, and the movement has been verified experimentally, which confirms the effectiveness of the proposed procedure. In conclusion, the DFD procedure with trade-off optimization is utilized successfully to design the grating unit for maximum ranges of grating movements.