bluuebunny/crossref_metadata_2025 huggingface dataset:
Significance of Serum Expression of Rho Kinase, Endothelin-1, and Nitric Oxide in Pediatric Patients With Left-to-right Shunt Congenital Heart Disease Accompanied by Pulmonary Hypertension
Authors: Sun Xing-Zhen , Hu Jian , Tian Xiang-Yang , Hong Ze
Published: July 2020

Background

The study aimed to investigate the serum expression levels of Rho kinase, endothelin-1 (ET-1), and nitric oxide (NO) in pediatric patients with left-to-right shunt congenital heart disease (CHD) and their correlation with pulmonary artery systolic pressure (PASP).
Methods

90 pediatric patients diagnosed with left-to-right shunt CHD and hospitalized were selected as the study objects.They were divided into three groups according to their PASP: the non-pulmonary artery hypertension (non-PAH) group (PASP < 30 mmhg), the mild PAH group (PASP 30–49 mmhg), and the moderate to severe PAH group (PASP ≥ 50 mmhg). Healthy children were selected as the control group. Enzyme-linked immunosorbent assay, radioimmunoassay, and nitrate reductase assay were used to determine the patients’ serum levels of Rho kinase, ET-1, and NO, respectively. The correlation between PASP and the above indexes was analyzed.
Results

In pediatric patients with left-to-right shut CHD, the serum expression levels of Rho kinase and ET-1 were higher than in the control group members, while the serum expression level of NO was lower. In pediatric patients with CHD accompanied by pulmonary hypertension (PH), the expression levels of Rho kinase and ET-1 were even higher, and the level of NO even lower, than in patients and control group members without PH. The serum levels of Rho kinase and ET-1 were positively correlated with PASP, while the serum level of NO was negatively correlated with PASP.
Conclusion

Rho kinase, ET-1, and NO may be involved in the development of PH in pediatric patients with left-to-right shunt CHD.
Does Estradiol Orally and Vaginally Administered Together Impact Live Birth and Neonatal Outcome in Artificial Frozen-thawed Embryo Transfer Cycles: A Retrospective Cohort Study
Authors: Liu Yuan , Yang Yixia , Zhou Xinting , Hu Yanmei , Wu Yu
Published: July 2020

Background: Previous studies have demonstrated that newborns from fresh embryo transfer are with higher risk of small for gestation (SGA) rate than those from frozen-thawed embryo transfer (FET). It is suggested that supraphysiologic serum estradiol in controlled ovarian stimulation (COS)is one of reasons. Out study aims to investigate whether exogenous estradiol delivered regimens have an impact on live birth rate and singleton birthweight in hormone replacement (HRT)-FET cycles.Methods:This retrospective study involved patients undergoing their first FET with HRT endometrium preparation followed by two cleavage-staged embryos transfer, comparing orally and vaginal estradiol tablets (OVE) group versus oral estradiol tablets (OE) group from January 2015 to December 2018 at our center. A total of 792 patients fulfilled the criteria, including 282 live birth singletons. Live birth was the primary outcome. Secondary outcome included clinical pregnancy rate, singleton birthweight, large for gestational age (LGA) rate, SGA rate, preterm delivery rate. Results:Patients in OVE group achieved higher serum estradiol level with more days of estradiol treatment. No difference in live birth (Adjusted OR 1.327; 95%CI 0.982, 1.794, p=0.066) and clinical pregnancy rate (Adjusted OR 1.278; 95%CI 0.937, 1.743, p=0.121) was found between OVE and OE groups. Estradiol route did not affect birth weight (β=-30.962, SE=68.723, p=0.653), the odds of LGA (Adjusted OR 1.165; 95%CI 0.545, 2.490, p=0.694), the odds of SGA (Adjusted OR 0.569; 95%CI 0.096, 3.369, p=0.535) or the preterm delivery rate (Adjusted OR 0.969; 95%CI 0.292, 3.214, p=0.959).Conclusion:Estrogen orally and vaginally together did not have an impact on clinical outcomes and singleton birthweight compared to estrogen orally taken, but was accompanied with relative higher serum E2 level and potential maternal undesirable risks.
Postpartum rupture of Splenic hydatid cyst: An extremely rare presentation of a rare condition
Authors: Ashraf Aabid , Wani Yaqoob Hassan , Bhat Javid Ahmad , Rather Ajaz Ahmad
Published: July 2020

BackgroundHydatid disease is endemic in some regions of the world. Even in endemic regions, splenic hydatid cysts are rare, especially in pregnancy. The most serious presentation is intra peritoneal rupture, which is a surgical emergency. Exploration with splenectomy is the favoured management.Case presentationWe present a case of splenic hydatid cyst detected late in pregnancy, which presented with intraperitoneal rupture in the postpartum period. A brief review in the context is also presented.ConclusionCystic lesions located anywhere in the body in endemic regions could be hydatid cysts. Prompt treatment should be planned immediately on detection in order to prevent potentially serious complications like rupture.
The Burden of the Current Curative Expenditure of Injury in Dalian, China-A study Based on "System of Health Accounts 2011"
Authors: Sun Shu , Yang Liuna , Hu Xinzhu , Zhu Yalan , Liu Boxi , Yang Yunbin , Wang Xin
Published: July 2020

Background: Injury is one of the major public health problems, which causes more than 5 million deaths in the world every year. Cases of specific types of injury put a tremendous threat to human health and also add a heavy medical burden on individuals and societies. This study was to calculate and analyze the current curative expenditure (CCE) of injury in Dalian and consequently to provide control strategies for decision-makers.Methodology: A total of 565 medical institutions were selected with multistage stratified cluster random sampling, containing 4,375,351 valid samples. Subsequently, the distribution of injury CCE in different dimensions (including age and site of injury) was analyzed under the framework of System of Health Accounts 2011(SHA 2011) using the established database.Results: There were increases from 32.36/100,000 in 2006 to 37.34/100,000 in 2017 and from 46.12/100,000 in 2006 to 54.48/100,000 in 2017 in urban and rural residents respectively. The study found that the CCE of injury in Dalian had reached 1572.73 million RMB, accounting for 7.45% of the total curative care expenditure. In the 15-25 age group, the cost of injury accounts for a larger proportion of CCE than other age groups. Among the injuries in different regions of the body, injuries to the spine, lower limb, head and foreign body entering cost the most.Conclusions: Dalian has a relatively serious burden of injury costs. The essential and primary goal is to reduce the cost and increase the benefit of attending to patients with injuries. Specific control strategies should be tilted toward the age group 15-25. Injuries to the spine, lower limb, head and foreign body entering also should be priorities of interventions.
Engaging Research Participants with Results: A Rights Informed Approach
Authors: George Mathew Sunil , Gaitonde Rakhal , Davey Rachel , Mohanty Itismita , Upton Penney
Published: July 2020

IntroductionSharing findings with research participants is gaining attention as an ethical imperative for the research community. However, current discussions on this topic typically take a paternalistic approach to the issue, with the research team having the power to decide whether or not the sharing of results should be carried out and how this is done. In this paper we propose an alternative approach to engaging participants with the findings from the research to which they have contributed.MethodsThe ethnographic fieldwork for our study was carried out in multiple phases from August 2018 to January 2019 and again from August 2019 to December 2019 among two vulnerable communities in the south Indian state of Kerala. Engagement of research participants with findings was integrated into the research protocol and various strategies including forming partnerships with participants and identifying appropriate forms of dissemination among the different categories of participants were carried out during fieldwork. The format and mode of dissemination varied depending on the participant category and was tailored to ensure that each participant was able to engage actively with the findings as opposed to merely passively receiving the results from our study,ResultsPrevious research studies that had been undertaken among our participants had not shared research results with them and were interpreted by the communities that researchers were not interested in making any difference to their situation. Building reciprocal relationships in a way that minimised power disparities and tailoring outputs to forms that promoted active engagement were key factors that helped participants to engage with our results. Such engagement added value to our research by enabling us to jointly evolve the recommendations from our study.Conclusion Participants contribute to the success of research by providing information that is sought by researchers. Compared to the dominant bio-medical research ethics framework, a rights informed approach to sharing research results with participants acknowledges this and recognises their agency to engage with research findings. Such an approach is not only socially responsible and ethical, but also improves the impact and legitimacy of research among the participants and the larger population that they represent.
UMA ANÁLISE SOBRE O CONCEITO DE ENERGIA EM LIVROS DIDÁTICOS DE FÍSICA
Authors: Salvador Heloiza , Portela Caroline Dorada Pereira
Published: July 2020

Apresenta-se um estudo sobre como o conceito de energia é abordado em livros didáticos de física, a partir da análise de novas tendências de ensino. Além do importante papel que os livros didáticos desempenham em sala de aula como ferramenta de apoio do aluno e do professor, a análise dos mesmos é de suma importância para que o professor consiga atingir um pleno desenvolvimento em suas aulas buscando contribuir para o processo de aprendizado sobre o conteúdo pelos alunos. Baseando-se em pressupostos teóricos, foram selecionadas e analisadas três coleções de livros didáticos de física para o ensino médio, aprovados no Programa Nacional do Livro Didático (PNLD) de 2018. Os resultados apontam que as novas tendências de ensino que estão imbricadas na contextualização do processo de aprendizagem da ciência física carregam em si um importante papel, como metodologias para que o aluno além de adquirir o conhecimento e aplicá-lo em sala de aula, também seja capaz de levar esses conhecimentos para a sua vida extracurricular, a partir da utilização da história e filosofia da ciência ou da experimentação e até mesmo a produção de conhecimento e opinião que colabore com a reflexão e propostas para os problemas sociais e ambientais do meio em que ele vive.
A water quality assessment model for Suya Lake Reservoir
Authors: Ji Xiaolei , Wang Xin , Yang Guoping
Published: July 2020

Reasonable water quality assessment of reservoirs plays an important part in strengthening water source management. Based on the monitoring data on the water quality in Suya Lake Reservoir provided by water quality environmental monitoring agencies, this paper selected typical water quality indexes such as dissolved oxygen, permanganate (CODMn), ammonia nitrogen (NH3-N), total phosphorus (TP) and total nitrogen (TN) as the water quality assessment factors, and applied the fuzzy comprehensive evaluation method to assess the quality of water in the Suya Lake Reservoir on the basis of single factor assessment. The result shows that the fuzzy comprehensive evaluation method can accurately quantify the fuzzy assessment of water quality. The main pollution factors in Suya Lake Reservoir are TP and TN, and pollution mainly occurs in the waters on the west bank of the reservoir (between the Cold Water River and the Lianjiang River), with the Huangxi River and its inlet being the most seriously polluted. This study provides some reference for the improvement to the water quality assessment model and scientific basis for the prevention and control of water environment pollution in the reservoir area.
Prosopografias clubbers em São Paulo e Londres:
Authors: Guerra Paula , Grimaldi Figueredo Henrique
Published: July 2020

Neste artigo, procuramos analisar o movimento clubber de São Paulo nos anos 1990 enquanto potenciador de inovação na moda e no imaginário visual contemporâneo. Neste ensejo, iremos tomar como comparação a cena londrina clubber da mesma época, prosopografando duas figuras centrais de ambas as cenas: Alexander McQueen e Alexandre Herchcovitch. O nosso principal argumento é o de que as cenas clubbers vividas nos anos 1990 por estes dois designers de moda ativam de forma independente energias e socialidades lúdicas entrecruzando criação, intermediação e fruição cultural na pista de dança. Estas cenas são espaços de polivalência (e simultaneidade) de papéis criativos. Rede, simultaneidade, polivalência, interdisciplinaridade, materialidade, imaterialidade assumem-se como atributos inelutáveis das cenas musicais que se transportam para os clubes, e posteriormente para as carreiras de McQueen e Herchcovitch.
Biedronki (Coleoptera: Coccinellidae) odłowione przy użyciu samołówek świetlnych w trzech kompleksach leśnych we wschodniej i centralnej Polsce
Authors: Kamiński Przemysław , Tobiasz Sebastian , Grochowska Małgorzata , Baranowski Artur , Romanowski Jerzy , Ceryngier Piotr
Published: July 2020

Chrząszcze z rodziny biedronkowatych (Coccinellidae), jako ważny czynnik ograniczający liczebność stawonogów powodujących szkody w uprawach, są częstym obiektem badań entomologicznych. Do odłowów stosuje się różne metody, przy czym do rzadziej wykorzystywanych należy metoda przywabiania chrząszczy do światła. W niniejszych badaniach zastosowaliśmy tę metodę do odłowu biedronek w rezerwacie Jata k. Łukowa oraz w dwóch kompleksach leśnych położonych w granicach administracyjnych Warszawy: w rezerwacie Las Bielański i w Lesie Młocińskim. Nocne odłowy owadów do samołówek świetlnych prowadzono w latach 2018 i 2019 między marcem a listopadem, jednak biedronki wpadały do pułapek w okresie od kwietnia do września. Łącznie na trzech stanowiskach odłowiono 347 osobników Coccinellidae należących do 16 gatunków. Największe bogactwo gatunkowe (15 gatunków), a jednocześnie najmniejszą średnią liczebność biedronek (1,3 osobnika na próbę) odnotowano w Jacie. W Lesie Bielańskim stwierdzono 9 gatunków i średnio 4 osobniki na próbę, a w Lesie Młocińskim 4 gatunki i średnio 2,2 osobnika na próbę. Na wszystkich trzech stanowiskach gatunkiem dominującym była Calvia decemguttata (L.). Wysoki udział miały również Harmonia axyridis (Pallas) i Vibidia duodecimguttata (Poda). Większość odłowionych osobników biedronek (71%) należała do gatunków pozbawionych ubarwienia ostrzegawczego, co może pośrednio świadczyć o ich nocnym trybie życia.
Bridging the Gap of Drug Delivery in Colon Cancer: The Role of Chitosan and Pectin Based Nanocarriers System
Authors: Deshmukh Rohitas
Published: July 2020

Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not
been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all
ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential
therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective
drug delivery system. The delivery systems employing the use of polymers, such as chitosan and
pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects
and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an
increased amount of the drug to reach the target tissue or cells. In this systematic review of published
literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted
delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the
use of chitosan and pectin in colon targeted drug delivery systems.
Evaluation of Disease Severity and Health-Related Quality of Life in Patients with Rheumatoid Arthritis Undergoing Total Knee Arthroplasty
Authors: Rahimnia Alireza , Alishiri Gholamhossein , Bayatpoor Mohammad E. , Hosseini Mohammad A. , Najafizadeh-Sari Shahriar , Yaribeygi Habib , Sahebkar Amirhossein
Published: July 2020

Background:

The Total Knee Arthroplasty (TKA) is one of the most common surgical
intervention in patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Previous studies
suggested a significant improvement in health status after TKA surgery. But we have little data
about the Iranian population undergone TKA. In the current clinical study, we evaluated postoperatively
health status using reliable tools of MOS SF-36 and WOMAC in OA and RA patients
undergoing TKA.

Methods:

In this cohort study, patients with OA and/or RA who were candidates for TKA surgery
were included. Using two reliable questionnaires, i.e., WOMAC and SF-36, the quality of life of
patients was examined during a period of six months (three monthly intervals) after the surgery. All
data were analyzed using IBM SPSS Statistics. Kolmogrov-Smirnov, Kendall’s tau, chi-square test
and K-related Non-parametric tests were used.

Results:

Of the 2126 patients who underwent TKA, there were 2024 diagnosed osteoarthritis and
102 validated RA over one year. The mean ± SD of age and the average BMI were 68.0 ± 7.0 BMI
28.5 kg/m2, respectively. Regarding comorbidities and concurrent disorders, about 14% of cases
were diabetic, 42% had cardiovascular diseases, 3% had respiratory diseases, and 12% involved
with gastrointestinal diseases. The result of SF-36 dramatically increased during follow up. The
central distributions of all domains in the SF-36 questionnaire indicated that most scores increased
during the time after surgery. As a consequence, WOMAC and MOS FS-36 indicated statistically
significant changes after TKA for those who are suffering from RA or OA.

Conclusion:

TKA is an effective surgical process, which improves the quality of life in OA and/or
RA. In addition, WOMAC and SF-36 examining tools are likely reliable tools with similar results
to assess patients’ quality of life after TKA surgery.
GREEN REPUBLICANISM AS A NON-NEUTRAL AND CONVIVIAL POLITICS
Authors: Pinto Jorge
Published: July 2020

Green republicanism can be described as a subset of republican political theory that aims to promote human flourishing by ensuring a non-dominating and ecologically sustainable republic. It expands the republican idea of social interdependence with the natural world, and therefore requires promoting and protecting the autonomy within those interdependencies. As such, green republicanism will focus on moving away from the current situation of ecological unsustainability while protecting freedom as non-domination. In this article, I offer a green republican justification for non-neutrality while remaining non-perfectionist. Furthermore, I argue that participation and deliberation is essential in defining the concrete politics that should guide green republicanism. To do so I examine the idea of conviviality and argue that green republicanism is the political theory best placed to ensure the objective of conviviality: it allows individuals to confront their views and to cooperate, acknowledging the finitude of the planet’s natural resources.
WORKING COMMUNITIES’ SIGNIFICANT HERITAGE URBAN RIVER CORRIDOR LANDSCAPE OF MELAKA CITY
Authors: Zainal Abidin Nor Arbina , Debra Flanders Cushing , Gillian Lawson
Published: July 2020

The existing landscape characters of urban river corridor of Melaka City have eroded due to unsustainable design outcomes due to inadequate policies and guidelines, indiscriminate decision in design and it lacks of community consultation. In addition, political intervention and climate change have made it worse to the present urban river corridor of the city. These issues have raised concerns among the local community, particularly those workers whose livelihood depend on resources in that area. This paper reveals the distribution patterns and landscape settings of the urban river corridor of Melaka City which are significant among working communities. It also describes each landscape setting within the identified territory. The findings are determined via thematic coding analysis and overlay mapping technique based on the experiential landscape theory established by Thwaites and Simkins (2007). The combination of experiential landscapes from different individuals via overlay mapping analysis also provides insight into the communities’ urban river corridor boundary of the city, which is important in heritage-related policy
THE ENTITY - IDENTITY RELATIONSHIPS OF OLD SHOP HOUSES IN PERAK THROUGH FACADE DESIGN
Authors: Mamat Mohd Jaki , Abdul Aziz Muhammad Firzan
Published: July 2020

Since the 19th century, old shop houses remaining in Malaysia have been a primary indicator of the country’s physical landscape which can inform significant historical background of early cities and towns. The old shop houses testify in the uniqueness and diversity of the nation’s architectural gems, which were shaped by the Malay, Chinese and British entities. The current study attempts to understand the influence of varying entities towards the architectural identities that the old shop houses’ facade bear. Purposive sampling of 16 towns in the state of Perak was made to gauge information on the earliest row of shop houses at each of the towns. Both secondary and primary data were then leveraged based on documents analysis, interviews and measured drawings to explore the relationship link between the entities and identities through the old shop houses’ facade design. The findings suggest that there is a relationship between the entities and identities, in the sense that the early entities were influential in determining the identities of the old shop houses’ facade design. Interestingly, the Malay style was found to be the most dominant identity depicted by the facade design of the old shophouses from the 16 towns of Perak.
EVOLUTION AND DIVERSIFICATION OF MUSEUM FUNCTIONS: A REFLECTION OF MARKET DEMAND IN PENANG, MALAYSIA
Authors: Rahman Suraiyati , Velayuthan Sathish Kumar
Published: July 2020

Changes in human values and technological advancements have led to the reinvention of museum interpretation. Studies have shown that the transformation of museums’ functions and emerging typology of museums occur globally. Initially, museums’ function was to educate society and preserve artefacts for public access, but nowadays, museums have expanded their functions and have become market driven. The increasing number of museum establishments in George Town, Penang has mixed impacts to the curatorship and interpretation of museums. The strategic location of George Town, Penang, its branding as a World Heritage Site, cultural heritage attractions, and local values have gained popularity as a touristic destination. Museums and galleries are the top attractions reviewed by users in TripAdvisor. This article investigates the transformation of functions and typology of museums on the basis of the top 20 museums in Penang listed in TripAdvisor. Content analysis from the secondary data was conducted to establish the pattern and trends of museums’ diversification in Penang. Findings revealed that the diversification of museums in Penang has expanded from histories such as natural, science, human, and art to history and art, technology, and specialty. Considering that George Town has been nominated as a World Heritage Site, museums have become consumer oriented, and private ownership and collaborative partnership have grown drastically. This study contributes by showing that the diversification of museums’ function enhances creativity to meet future needs.
PROFILE OF AEDES BREEDING IN URBAN HIGH-RISE BUILDINGS: A CASE STUDY OF DENGUE OUTBREAK IN MALACCA, MALAYSIA
Authors: W. Yahya Wan Nor Fareeda , Che Dom Nazri
Published: July 2020

An understanding of dengue vector ecology plays an integral role in the effective elimination of vector breeding sites. The aim of this study was to assess the profile of the breeding habitat of the Aedes mosquito in urban high-rise buildings in Malacca. This study utilized epidemiological data from 2013 to 2017 to determine the distribution of dengue cases and Aedes breeding sites in high rise buildings. The Analytical Hierarchy Process (AHP) was used to evaluate the characteristics of Aedes breeding in high-rise buildings. In addition, the age and the total number of floors in the high-rise buildings were found to be important determinants of DF. The findings from this study will aid in the identification of target areas, which in turn can support future community-based search-and destroy intervention efforts. Furthermore, the conclusions of this research may guide the future design and construction features of high-rise buildings in Malaysia, which in turn can contribute toward a holistic and sustainable environment in the country.
URBAN METABOLISM AND TRANSPORTATION ASSESSMENT OF KUALA LUMPUR, MALAYSIA
Authors: Shahidan Ahmad Afiq , Shafie Farah Ayuni
Published: July 2020

Carbon dioxide, a major greenhouse gas has become an indicator in global warming and climate change. Meanwhile, cities are a medium whereby the source of carbon dioxide is released due to the urbanization and transportation sector. This situation leads to unpredictable impact to the environmental, social and economic condition of the city. Kuala Lumpur is a capital city that experiences rapid growth and was chosen for input-output analysis while Bukit Bintang road and Tunku Abdul Rahman road were chosen for ambient air monitoring due to traffic congestion problems in the city centre. The ambient air quality monitoring was measured on Saturday, Sunday and Monday for 8 hours. The sampling started at 7.00 a.m until 3.00 p.m. with a 5-minute log interval. The study found that carbon dioxide emission from both roads in Kuala Lumpur contributed to 376 ppm of carbon dioxide showing that transportation was a massive source of greenhouse gas emission in the city. Meanwhile, the input-output analysis in Kuala Lumpur showed a significant increase between 2010 and 2016 where electricity consumption, food consumption input, water consumption, gas emission and wastewater output rise due to urbanization and increasing population in the city. In contrast, the enforcement of mandatory waste management by the government has resulted in the decrease of solid waste output in Kuala Lumpur. The greenhouse gas released output in terms of Global Warming Potential from the input-output analysis was 5.88 MMtCO2eq. The study showed that the impact of urbanisation such as ambient air pollution is closely related to energy consumption and greenhouse gas emission.
THE DEVELOPMENT CONTROL OF URBAN CENTRE IN KUALA LUMPUR
Authors: Yin Izuandi , Abdullah Jamalunlaili
Published: July 2020

The challenge in identifying the limit of the boundary of development growth in Kuala Lumpur is difficult. From the development control which creates the growth of Kuala Lumpur defines that, the allocation of development control for City Centre Commercial (CCC) development within the District Centre Commercial (DCC) development has resulted in different priorities and growth, unbalanced land use distribution within Kuala Lumpur, as well as creating the difference in the given plot ratio by the authority for each centre according to its importance that resulted in the growth that focuses on the CCC area hence resulted in the difference in law enforcement in determining the distribution of floor space. The objective is to identify the urban growth pattern and to examine the influence of built up area to the development. Using the qualitative and quantitative method such as allocation of intensity development in defining the growth of an urban centre in Kuala Lumpur, the analysis is made to study the intensity, and the built-up area correlates to the floor space optimisation, total plot ratio, gross development value and the density requirement. The study is also to analyse the implementation of intensity development, zoning of land use, high-density development, and the correlative relation of development control with the growth centre. It also aims to establish land use management and physical development in Kuala Lumpur City Centre for sustainable urban growth and proper management of development control. The outcome of the study is shows hierarchy of the chosen 11 growth centres in Kuala Lumpur.
Intimate Partner Violence and Electronic Health Interventions: Systematic Review and Meta-Analysis of Randomized Trials (Preprint)
Authors: Linde Ditte S , Bakiewicz Aleksandra , Normann Anne Katrine , Hansen Nina Beck , Lundh Andreas , Rasch Vibeke
Published: July 2020

BACKGROUND

Intimate partner violence (IPV) is a major public health concern. eHealth interventions may reduce exposure to violence and health-related consequences as the technology provides a safe and flexible space for the target population. However, the evidence is unclear.

OBJECTIVE

The goal of the review is to examine the effect of eHealth interventions compared with standard care on reducing IPV, depression, and posttraumatic stress disorder (PTSD) among women exposed to IPV.

METHODS

We searched EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials, PsycInfo, Scopus, Global Health Library, ClinicalTrials.gov, and International Clinical Trials Registry Platform for published and unpublished trials from inception until April 2019. Trials with an eHealth intervention targeting women exposed to violence were included. We assessed risk of bias using the Cochrane Risk of Bias Tool. Trials that reported effect estimates on overall IPV; physical, sexual, and psychological violence; depression; or posttraumatic stress disorder were included in meta-analyses.

RESULTS

A total of 14 trials were included in the review; 8 published trials, 3 unpublished trials and 3 ongoing trials. Of the 8 published trials, 2 were judged as overall low risk of bias trials. The trials reported 23 types of outcomes, and 7 of the trials had outcomes that were eligible for meta-analyses. Our pooled analyses found no effect of eHealth interventions on any of our prespecified outcomes: overall IPV (SMD –0.01; 95% CI –0.11 to 0.08; I2=0%; 5 trials, 1668 women); physical violence (SMD 0.01; 95% CI –0.22 to 0.24; I2=58%; 4 trials, 1128 women); psychological violence (SMD 0.07; 95% CI –0.12 to 0.25; I2=40%; 4 trials, 1129 women); sexual violence (MD 0.36; 95% CI –0.18 to 0.91; I2=0%; 2 trials, 1029 women); depression (SMD –0.13; 95% CI –0.37 to 0.11; I2=78%; 5 trials, 1600 women); and PTSD (MD –0.11; 95% CI –1.04 to 0.82; I2=0%; 5 trials, 1267 women).

CONCLUSIONS

There is no evidence from randomized trials of a beneficial effect of eHealth interventions on IPV. More high-quality trials are needed, and we recommend harmonizing outcome reporting in IPV trials by establishing core outcome sets.

CLINICALTRIAL

PROSPERO International Prospective Register of Systematic Reviews CRD42019130124; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=130124
Japanese Adjective Conjugation Patterns and Sources of Difficulty in Foreign Language Learning
Authors: Liu Xuexin
Published: July 2020

This paper is a study of the complexity of Japanese adjective conjugations in relation to sources of foreign language learning difficulty. It focuses on two types of adjectives: i-adjectives and na-adjectives and their conjugation patterns, including their respective morphological requirements for particular grammatical functions. This study regards knowledge of Japanese adjective conjugations as one of the levels of abstract lexical structure: morphological realization patterns. To explore sources of learner errors in producing Japanese adjective conjugations, the speech performance data are from two groups of adult speakers of American English learning Japanese as a foreign language. This study makes two claims: Any successful acquisition of a foreign language must involve the complete acquisition of not only foreign language lexical items but also its morphological realization patterns, and any successful foreign language learner must be able to use language-specific morphological realization patterns as surface devices in speech production. This study offers some pedagogical suggestions for successful acquisition of Japanese adjective conjugation patterns.
EVALUATION OF ACUTE AND SUB-ACUTE ORAL TOXICITY OF CLINACANTHUS NUTANS LEAVES EXTRACT IN MICE
Authors: GIANG TRAN THI LINH , THACH LE KIM , LINH LE NGUYEN TU , DAO VU QUANG , BEN TRINH THI , THACH BUI DINH
Published: July 2020

Objective: This study aimed to evaluate acute and sub-acute oral toxicity of ethanol extract of Clinacanthus nutans leaves in Swiss mice.

Methods: Acute oral toxicity study was performed as per OECD-423 guidelines. Sub-acute oral toxicity study was performed as per OECD-407 guidelines. The extract was dissolved in 10% dimethyl sulfoxide and administered orally, while the control group received only the vehicle.

Results: The acute oral toxicity test on mice showed that this extract was well tolerated up to LD50 5000 mg/kg body weight/day oral dosage level and non-toxic to mice under the present experimental conditions. The sub-acute toxicity study was carried out on mice with the oral dosage of the extract from 100 mg/kg–500 mg/kg body weight/day and 5000 mg/kg body weight/day for 28 d. The results showed that this extract did not induce death or adverse effects in activity, feed consumption or body weight gain. There were not significant changes in heamotological and biochemical parameters between control and experiment groups.

Conclusion: Thus, Clinacanthus nutans leaf has a very low toxicity value.
THE IMPORTANCE OF ANTIBIOTICS IN A VARIOUS UNIQUE METASTASIS ALONG WITH CYTOTOXIC THERAPY AT TERTIARY CARE HOSPITAL: A PROSPECTIVE COHORT STUDY
Authors: KIRAN G. SAI , KUMAR N. DOONDI PHANI
Published: July 2020

Objective: Rare cancers are creating a massive challenge to the world. It has associated with genetic mutations or socio-environmental factors, which includes genes, smoking, alcohol, ionizing radiation exposure, organic-inorganic chemicals, air and water pollution, viruses, and bacteria. When 15 cases per 1,00,000 people per year, we can consider it as a rare case as per the National Cancer Institute

This study aim is the importance of antibiotics in various unique metastasis along with cytotoxic therapy at tertiary care hospital.

Methods: The inclusion criteria of our study include a person who is suffering from rare metastasis at an early stage. We excluded the data that are those who are suffering from the typical type of cancers, multiple co-morbid conditions. This study was carried out the Prospective Cohort Study conducted between June 2018 to March 2020.

Results: Number of 20 rare cancers we consider for final analysis, the overall antibiotics use in this study 18 antibiotics they prescribed in overall cases, prescribed cytotoxic drugs are 23. the chi-square test value is P=0.001, the confidence interval(CI) is 95%, the likelihood ratio is 54.4, odd’s ratio is 2.0(CI 95%, P=0.711), Male patients more than the female patients.

Conclusion: Cancer is a complex disorder, which is occurred through gene proliferation and socio-environmental factors. Rare metastasis is challenging to physicians and patients, however as per our observation, cytotoxic therapy with antibiotics can reduce the risk of rare metastasis and as well improved therapeutic adhesion, and we need clear supporting evidence on it through clinical trials.
NATURAL COMPOUNDS FROM DJIBOUTIAN MEDICINAL PLANTS AS INHIBITORS OF COVID-19 BY IN SILICO INVESTIGATIONS
Authors: ELMI ABDIRAHMAN , SAYEM S. AL-JAWAD , AHMED MOHAMED , ABDOUL-LATIF FATOUMA
Published: July 2020

Objective: The new coronavirus type SARS-Cov 2 (severe acute respiratory syndrome), which appeared in autumn 2019 in China, became a global pandemic in a few months. In this work, we looked for the potential anti SARS-Cov 2 of the compounds isolated from three Djiboutian medicinal plants, namely Acacia seyal, Cymbopogon commutatus, and Indigofera caerulea.

Methods: We carried out a molecular docking with nine biomolecules, β-Sitosterol, Quercetin, Catechin, Lupeol, Rutin, Kaempferol, Gallic acid, Piperitone and Limonene on three target sites which are SARS-CoV-2 main protease (Mp), SARS-CoV-2 receptor-binding domain (RBD) and human furin protease. These targets are chosen because of their role in the process of penetration of the virus into human cells and its multiplication. Moreover, the predictions of pharmacokinetic parameters as well as toxicological properties have been determined using an online bioinformatics tool named SwissADME and AdmetSAR respectively.

Results: The phenolic compounds have a very good affinity on these three target sites with binding energies of up to-9.098 kcal/mol for rutin on SARS-CoV-2 Mp, much better than the two reference drugs hydroxychloroquine (-5.816 kcal/mol) and remdesivir (-7.194 kcal/mol). Except for β-Sitosterol, the tested biomolecules have weak toxicity.

Conclusion: These natural compounds can be used against covid 19 pending In vitro and In vivo evaluations.
HYDROTROPIC SOLUBILIZATION AND LINEARITY PROFILE OF PAZOPANIB
Authors: KARAJGI SANTOSH , POTADAR SHRIPAD
Published: July 2020

Objective: A study on the hydrotropic solubility and linearity profile of Pazopanib was carried out by using Niacinamide as the solubilizing agent as Pazopanib is poorly soluble in water.

Methods: Pazopanib was freely soluble in water when 2.8M Niacinamide was used as a solubilizing agent. Pazopanib shows an absorption maximum at 282 nm in First derivative mode of measurement using Shimazdu UV Spectrophotometer 1800 spectronic model.

Results: At the absorption maximum of 282 nm, Pazopanib shows a linear response in the range of 5μg/ml to 15μg/ml concentration.

Conclusion: The present study is useful for the aqueous solubilization and quantitative determination of Pazopanib in bulk drug and in pharmaceutical formulations thus avoiding toxic solvents.
IN VITRO EVALUATION OF IMMUNOMODULATORY ACTIVITY OF ETHANOLIC EXTRACT OF MORINGA CONCANENSIS NIMMO
Authors: SINGUNE SHANTILAL , VAGHELA J. S.
Published: July 2020

Objective: The present study was undertaken to evaluate immunomodulatory activity of ethanolic extract and isolated compound from the whole plant of Moringa concanensis Nimmo

Methods: Immunomodulatory activities were determined by in vitro models-plaque-forming cell assay, nitric oxide (NO) radical scavenging activity, inhibit RAW 264.7 macrophage cell line from generating harmful NO induced by lipopolysaccharide (LPS) and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay.

Results: Showed significant (P<0.01) phagocytic effect on human neutrophils in the parameters studied. Scavenged nitric oxide radical by ethanolic extract of Moringa concanensis inhibition 34% and isolated compound scavenged nitric oxide radical inhibition 44% respectively compared to control group exerted 52% decrease of nitric oxide radical respectively concentration at 0.1,0.01 and1.0 mg/ml. LPS in murine macrophage, RAW 264.7 cells culture medium induced a high release of NO but pretreatment with Moringa concanensis extract and isolated compound resulted in inhibition of NO production by 29, 37, 95 % and 32,44,96 % at concentrations of 0.5, 0.1 and 1.0 mg/ml, compared to LPS-induced sample. ethanolic extract and isolated compound significantly stimulate RAW 264.7 cell viability (P<0.001) by MTT assay.

Conclusion: The present experimental finding demonstrated that isolated compound has superior immunomodulatory activity than the ethanolic extract of Moringa concanensis this effect presumably due to the greater ability of an isolated compound to boost the innate and adaptive immune system.
Positive activity untuk meningkatkan kepercayaan diri pada pasien skizofrenia
Authors: Umami Ulya Rahmatullatifa
Published: July 2020

Subjek memiliki kerentanan psikologis yang membuat Subjek mengalami berbagai hambatan dalam kesehariannya. Hasil asessmen menggunakan observasi, wawancara dan alat test psikologi menunjukkan bahwa Subjek terdiagnosa gangguan Skizofrenia dengan permasalahan rendahnya kepercayaan diri. Rendahnya kepercayaan diri Subjek menimbulkan hambatan dalam performa subjek. Subjek menjadi tidak produktif dalam kesehariannya karena selalu menolak untuk mengerjakan suatu tugas atau mengikuti kegiatan. Intervensi dilakukan menggunakan teknik positive activity dengan pendekatan behavior. Tujuan intervensi meningkatkan kepercayaan diri subjek. Instrumen menggunakan Self-confident Scale sebagai pretest dan posttest. Hasil intervensi ¬¬¬-menunjukkan adanya perubahan perilaku pasif Subjek mulai berkurang, intensi Subjek membicarakan mengenai kondisi fisiknya yang kurang menarik mulai berkurang dan pemahaman Subjek mengenai kepercayaan dirinya mulai bertambah.
Contractual Liability dalam Perjanjian Keagenan Gas Elpiji Non-Public Service Obligation
Authors: Kusnadi Ricky , Budiartha I Nyoman Putu , Ujianti Ni Made Puspasutari
Published: July 2020

Pertamina selaku produsen (prinsipal) menjual produk kepada konsumen melalui agen menyebabkan Pertamina tidak berhubungan langsung dengan konsumen, maka tidak ada contractual liability antara produsen dan konsumen. Rumusan masalahnya adalah: 1) Bagaimana hubungan hukum antara prinsipal dan agen berdasarkan perjanjian keagenan gas Elpiji Non-PSO?; 2) Bagaimanakah contractual liability berdasarkan perjanjian keagenan gas Elpiji Non-PSO?. Tipe penelitian ini adalah yuridis normatif dengan pendekatan perundang-undangan dan disajikan dalam bentuk interpretasi hukum. Perjanjian keagenan antara prinsipal dan agen tidak diatur secara khusus dalam KUH Perdata dan KUHD, namun asas kebebasan berkontrak membolehkan adanya Perjanjian Keagenan. Perjanjian Keagenan yang dibuat antara Pertamina dan Agen Gas LPG Non-PSO menimbulkan hubungan hukum yang tercermin dalam hak dan kewajiban masing-masing pihak yang apabila tidak dipenuhi merupakan wanprestasi. Contractual liability merupakan pertanggungjawaban hukum dalam perjanjian. Pertamina memberikan sanksi bertahap kepada agen gas LPG. Agen Gas LPG tidak diperbolehkan merubah harga jual dan pengurangan isi tabung kepada konsumen, sehingga apabila terjadi gugatan konsumen maka Pertamina dibebaskan dari tuntutan pihak ketiga. Ranah perkara perdata apabila setiap perbuatan subjek hukum bertentangan dengan subjek hukum lainnya, sementara itu perkara tersebut dapat dipidanakan apabila perbuatan subjek hukum bertentangan dengan hal-hal yang merupakan objek hukum.
PENGARUH EDUKASI PASAR MODAL TERHADAP PERSEPSI RISIKO DAN MINAT BERINVESTASI MASYARAKAT
Authors: Dewi Pratiwi
Published: July 2020

The majority of our society is not yet aware of the benefits of investing. They emphasize more importance to support life now without understanding the future. In Indonesia, based on data as of December 2018, only around 1,617,367 million were approved as independent shareholders in the Indonesian Central Securities Depository. The ratio is not even up to 0.5 percent of the total population of Indonesia. Market information and market knowledge are the main things. Today many countries agree to investment plans that want to increase domestic and international investment. This study aims to reveal the effect of capital market education on risk perceptions and community investment interests. Researchers want to look at the factors that influence the interest of investing in the community who incidentally do not have experience in investing in the stock market capital. This study uses primary data that is a questionnaire collected from participants, using a quasi-experimental technique in which participants are people who take part in voluntary capital market school activities at the Indonesian Stock Exchange KP Denpasar. The method of processing data uses path analysis. The results of this study capital market education has a positive influence on people's perceptions of interest and investment interest. While the perception does not have an interest in the interests of investing in the community.
UKURAN PERUSAHAAN DAN PROFITABILITAS SEBAGAI DETERMINAN NILAI PERUSAHAAN MANUFAKTUR DENGAN STRUKTUR MODAL SEBAGAI VARIABEL MEDIASI
Authors: Astakoni Made
Published: July 2020

Penelitian ini memiliki beberapa tujuan yaitu; 1) untuk mengetahui dan menganalisis  pengaruh ukuran perusahaan (size)  terhadap nilai perusahaan ; 2)  untuk mengetahui dan menganalisis  pengaruh ukuran perusahaan terhadap struktur modal;3) untuk mengetahui dan menganalisis  pengaruh profitabilitas terhadap struktur modal; 4) untuk mengetahui dan menganalisis  pengaruh profitabilitas terhadap nilai perusahaan; 5) untuk mengetahui dan menganalisis  pengaruh struktur modal terhadap nilai perusahaan; 6) untuk mengetahui dan menganalisis peran struktur modal dalam memediasi hubungan ukuran perusahaan dengan nilai perusahaan;7) untuk mengetahui dan menganalisis peran struktur modal dalam memediasi hubungan profitabilitas dengan nilai perusahaan. Populasi  dalam studi  ini  adalah perusahaan manufaktur sektor kosmetik dan keperluan rumah tangga  yangterdaftar di Bursa Efek Indonesia (BEI) periode 2011-2018. Pengambilan sampel dilakukan secara purposive dengan  kriteria yang telah ditetapkan sebelumnya. Analisis data studi ini menggunakan pendekatan Partial Least Square (PLS). Hasil perhitungan menunjukkan bahwa hipotesis pertama;yang menyatakan bahwa terdapat pengaruh signifikan positif antara ukuran perusahaan terhadap nilai perusahaan tidak dapat diterima. Hipotesis kedua  yang menyatakan ukuran perusahaan  (size)  berpengaruh     positif  signifikan  terhadap struktur  modal  tidak dapat diterima. Hipotesis ketiga  yang menyatakan profitabilitas (profitability)     berpengaruh    negatif  signifikan  terhadap struktur  modal   tidak dapat diterima Hipotesis keempat yang menyatakan bahwa terdapat pengaruh signifikan positif antara profitabilitas terhadap nilai perusahaan dapat diterima. Hipotesis kelima yang menyatakan bahwa terdapat pengaruh signifikan positif antara struktur modal terhadap nilai perusahaan tidak dapat diterima.  Berdasarkan perhitungan, variable struktur modal belum mampu menjadi variable mediasi dalam mengintervensi pengaruh ukuran perusahaan  terhadap nilai perusahaan.Sedangkan pada sisi lain variable struktur modal mampu menjadi mediasi dalam mengintervensi pengaruh profitabilitas  terhadap nilai perusahaan.
النصوص العربية� ظاهرة التكرار وبالغته
Authors: Berdan Aiyub
Published: July 2020

� ظ رت بوضوح �ي ت النصوص العربية. وتلك الظاهرة ال�فملخص: و�ت دف هذه الدراسة إىل الكشف عن ظاهرة التكرار �ت تد إىل تكرار العبارة.ي تبدأ من تكرار الملكة الواحدة و�خ ت تلفة ال�ي ي مستو��ت ا املفالنصوص العربية منذ جاهلي�ت ت م ح� الوقت الراهن �يأ� تي ي صور عديدة، وكذالك �في القرآن �فج د أن التكرار ورد �ني ويعد التكرار طريقا من طرق التعب�، وهل قيمته الفنية والبالغية. امك �ي ي تتساوق ف� ي ا الفكرة مع الفن التعب�ي عىل أدق وجه وأمكل صورة.ي القرآن ت عىل الصورة ال�في احلديث النبوي امك جاء �فأسلوب �ال
Kajian Naskah Mushaf Kuno di Aceh: Potensi dan Prospeknya
Authors: Syarifuddin Syarifuddin
Published: July 2020

Al-Qur’an copying has been carried out by various walks of life from various sides since the centuries. This article examines ancient manuscripts from historical aspects, to see the potential and prospects of the study of the ancient manuscripts, by collecting literature studies, interviews, and observations or direct observation is carried out to see and examine how the manuscript is treated. From the results of this ancient manuscript research, it can be seen the development of the writing and copying of the Koran in various forms, variety and appearance, various beautiful illuminations that have peculiarities, and their own uniqueness. Even the writing text uses different calligraphy between one manuscript and another. With this research can provide more extensive learning about ancient manuscripts, so that this manuscript is not only seen as a holy book in terms of religion, but also education, especially education related to manuscripts from the codicological and philological aspects.