bluuebunny/crossref_metadata_2025 huggingface dataset:
A multi-method approach to drafting candidate entrustable professional activities for a general internal medicine residency programme
Authors: Monti Matteo , Pittet Valérie , Frick Sonia , Gachoud David
Published: May 2024

INTRODUCTION: Entrustable professional activities (EPAs) are units of concrete daily clinical tasks that trainee physicians should be able to handle with increasing autonomy during their postgraduate training. EPAs are gaining international recognition as an essential component of competency-based medical training programmes. The process of developing EPAs for a nationwide training programme is complex and requires an in-depth understanding of EPAs as a concept and good knowledge of appropriate development processes. This article provides a detailed description of the methodology and results of a multi-step approach for developing a list of candidate EPAs for Switzerland’s postgraduate training programme in general internal medicine (GIM).
METHODS: We took a multi-step approach including a systematic review of international literature, four national focus groups, a national consensus process using a RAND appropriateness method, and a quality check of the selected candidate EPAs using EQual criteria.
RESULTS: These steps generated a final list of 247 candidate EPAs in general internal medicine that were submitted for the national consensus process. After two rounds of rating, experts agreed on the appropriateness for general internal medicine postgraduate training of 225 candidate EPAs. Twenty-two were deemed inappropriate, and disagreement persisted only for two EPAs.
DISCUSSION: This multi-step programme is one of the few describing in detail the process of developing a list of EPAs and providing evidence of validity at each step. The clinical breadth of our candidate EPAs, together with the detailed description of our methodology, could serve as a useful starting point from which medical education specialists or clinicians could develop or revise applicable lists of EPAs, particularly for postgraduate training programmes in either general internal medicine or family medicine.
Disc hemorrhage with low intra-ocular pressure, an evidence-based approach
Authors: Besada Eulogio , Frauens Barry
Published: May 2024

Purpose

To document a case of low intraocular pressure (IOP) that developed a disc hemorrhage (DH) and subsequent corresponding pre-perimetric retinal nerve fiber layer (RNFL) loss on spectral domain optical coherence tomography (SDOCT). Current concepts on etiology and evidence-based management of optic nerve hemorrhages in glaucoma and normo-tension cases are discussed.

Methods

Case report. A superior temporal flame shaped hemorrhage was observed at the disc margin OD of a 57-year-old female with unremarkable health. A SDOCT exhibited a normal RNFL. Throughout three years the patient developed progressing superior temporal RNFL on SDOCT. Humphrey visual field (VF) was normal. The cup/disc ratio (c/d) was 0.7/0.7 with slight superior thinning and corresponding RNFL defect on photos compared to those at the initial occurrence of the disc hemorrhage. The highest recorded IOP over all visits was 13 mm Hg.

# Conclusion

Evidence based documentation indicates that the occurrence of a DH may lead to RNFL loss or progression of VF loss. Although lamina cribrosa (LC) defects are concomitantly associated with DH, the causality may be indirectly related. The rate of RNFL loss may be reduced in normal tension patients by lowering intraocular pressure. Further medical treatment consequently may be beneficial. Bruch’s membrane opening minimum rim width demonstrates a greater rate of change compared to that of RNFL and therefore may help identify earlier glaucoma stages. Vascular and laminar damage may have a similar etiological mechanism. A proposed membrane glymphatic theory of primary glaucoma may clarify the currently unidentified underlying mechanisms that lead to glaucoma progression.
Anterior Diffuse Scleritis: A Case Report and Review
Authors: Li Ziqing (Jennifer)
Published: May 2024

The sclera, serving as the eye’s outer opaque covering, played a vital role in preserving the integrity of the eyeball and providing attachment points for muscles. Beyond its function in safeguarding front surface structures, it also integrates with the optic nerve head. Scleral irregularities encompassed variations in coloration, such as ocular melanosis and jaundice, instances of inflammation, such as episcleritis and scleritis, and surgical modifications like scleral buckle and filtering bleb procedures. Inflammation of the sclera, while not an uncommon occurrence, necessitated a crucial distinction between episcleritis and scleritis to ensure swift management, treatment, and prognosis assessment. A 46-year-old Caucasian male presented with a painful, red, and watery right eye. He notes no previous trauma or medical conditions other than a potential for hypothyroidism. Examination revealed pain with eye movement, tenderness around the adnexa, significant conjunctivochalasis, and 4+ bulbar hyperemia that did not blanch completely with 2.5% phenylephrine. A diagnosis of anterior diffuse scleritis was made, and treatment began with Pred Forte ® and Aleve ®. He was then referred to the family doctor for further testing to rule out underlying systemic conditions. Scleritis is a noteworthy inflammatory disorder due to its propensity to cause complications which could impair eyesight and its correlation with systemic immune-mediated illnesses. The severity of presentations may vary, and scleritis has the potential to serve as the first indication of systemic autoimmune disorders. Hence, it is essential to do a comprehensive examination of the patient’s medical history, examine their systems, and perform specific laboratory investigations for all individuals. The timely detection of individuals with concomitant systemic illnesses may play a crucial role.
Data sharing in the personal data economy. Does sharing mean caring?
Authors: Owusu Abigail
Published: May 2024

Following its approval by the European Parliament in April 2022, the Data Governance Act (DGA) introduces regulation for the providers of data intermediation services. The Regulation seeks to empower data subjects and ensure the competitiveness of the markets in which data intermediaries operate. After providing the necessary background, this paper aims at offering a first general overview, from a private law standpoint, on both merits and limitations of the regulatory approach on data sharing adopted by the DGA. It outlines questions that need to be addressed in order to verify thatthe Regulation delivers the benefits it promises.
Enhancing Workforce Agility of National Insurance Firm’s Employees by Effective E-Learning Management and Growth Mindset
Authors: Tannady Hendy , Wardhana Aditya , Sudrajat Dadang
Published: May 2024

This study aims to determine the effect of e-learning and growth mindset to workforce agility at Insurance Company XYZ. This study using qualitative approach as well as observation and interview to collect data and information about the problems that might be happen. This study conducted interviews with 5 persons who are the employees of Insurance Company XYZ.In this study it was found that there were various positive and negative impacts. Even tho, the results of this study show that e-learning and growth mindset have an effect on workforce agility at Insurance Company XYZ. Therefore, the researcher give the suggestion for Insurance Company XYZ is to always empower, motivate and provide moral support for the employees to be able to provide the best for the company and not give up easily at work.
The Influence of Health Awareness and Product Knowledge on Intention to Purchase Lemonilo Instant Noodle Products Mediated by Attitude in Pekanbaru City
Authors: Deni Normala , Wijayanto Gatot , Nursanti Aida
Published: May 2024

This research aims to determine the influence of health awareness and product knowledge on intention to buy Lemonilo Instant Noodle products, which is mediated by attitudes in Pekanbaru City. The research was conducted on the people of Pekanbaru City who know and understand the Lemonilo Instant Noodle product by distributing questionnaires to 140 respondents as a sample. The sampling technique used in this research is non-probability sampling with Purposive Sampling technique. The data analysis technique uses the Structural Equation Modeling (SEM) method with Partial Least Squares (PLS) using Smart-PLS Software version 3.2.9. The research results show that health awareness and product knowledge have a significant effect on attitudes towards Lemonilo Instant Noodle products in Pekanbaru City. Health awareness, product knowledge and attitudes have a significant influence on interest in purchasing Lemonilo Instant Noodle products in Pekanbaru City. Health awareness and product knowledge have a significant effect on intention to buy Lemonilo Instant Noodle products, which is mediated by attitude in Pekanbaru City.
The Influence of Viral Marketing and Endorsers on Brand Awareness and Purchasing Decisions for Street Boba Pekanbaru Products
Authors: Rahmadani Novi , Wijayanto Gatot , Wasnury Rendra
Published: May 2024

This study aims to determine and analyze the influence of Viral Marketing and endorsements on purchasing decisions with Brand Awareness as an moderatingvariable on Street Boba Pekanbaru. The approach used in this research is quantitative using the SEM-PLS model and SmartPls 4.0 software as tools for this research. Data ware obtained through distributing questionnaires to 385 respondents. The results of this research reveal that: (1) there is a positive and significant influence of Viral Marketing on purchasing decisions at Street Boba Pekanbaru, (2) there is a positive and significant influence of Endorser s on purchasing decisions at Street Boba Pekanbaru, (3) there is a positive and significant influence of Viral Marketing on Brand Awareness on Street Boba Pekanbaru, (4) there is a positive and significant influence of Endorser s on Brand Awareness on Street Boba Pekanbaru, (5) there is a positive and significant influence of Brand Awareness on purchasing decisions on Street Boba Pekanbaru. (6) there is a positive and significant influence of Viral Marketing on purchasing decisions with Brand Awareness as an moderatingvariable on Street Boba Pekanbaru, (7) there is a positive and significant influence of Endorser s on purchasing decisions with Brand Awareness as an moderatingvariable on Street Boba Pekanbaru.
Avaliando a Performance de SGBDs na Inserção e Consulta de Dados de Séries Temporais
Authors: Lima Marcelo Costa de , Lichtnow Daniel
Published: May 2024

O objetivo deste trabalho é avaliar a performance de SGBDs na inserção e consulta de dados de séries temporais procurando identificar quando Bancos de Dados de Séries Temporais devem ser usados no lugar de Bancos de Dados Relacionais. Foram feitos experimentos com PostgreSQL, InfluxDB e TimeScaleDB variando o volume de dados e avaliando o tempo de execução. Os resultados iniciais e a comparação com outros trabalhos indicaram a necessidade de avaliar os requisitos de cada cenário de uso para definir o tipo de SGBD a ser utilizado para estes dados.
Digital Twin no Contexto de Mobilidade Urbana
Authors: Yamauchi Cássio K. , Costa Marcelo G. da , Zavadzki Leonardo S. , Kozievitch Nádia P.
Published: May 2024

A mobilidade urbana é um tema muito debatido devido ao impacto direto que apresenta na vida de inúmeros moradores do ambiente urbano. Uma mobilidade urbana inadequada pode significar a diferença entre a vida e a morte de uma vítima de acidente, podendo acarretar atrasos no atendimento médico, movimentos bruscos no transporte do paciente e até danificação das próprias ambulâncias. Nesta direção, o objetivo desse trabalho em andamento é a análise do projeto e de desafios, do ponto de vista de Digital Twin, tomando como base artigos que visaram padronizar a modelagem de cidades inteligentes.
Aplicação de mineração de dados para identificação de possíveis inadimplentes em uma cooperativa do ramo agrícola
Authors: Duarte Jaisson , Manica Edimar
Published: May 2024

A inadimplência é um problema que afeta tanto os consumidores quanto as empresas, comprometendo o crédito e gerando prejuízos financeiros. Estudos recentes revelam a preocupante situação do Brasil nesse contexto. Além disso, as cooperativas do ramo agropecuário também enfrentam desafios em relação à inadimplência, uma vez que lidam com transações financeiras e têm um grande número de clientes, o que dificulta a avaliação de crédito. Neste artigo, é descrito o desenvolvimento de um modelo de classificação capaz de identificar os clientes com maiores chances de inadimplência. O modelo combina os algoritmos RandomizableFilteredClassifier e NaiveBayes, alcançando uma revocação de 67%. Dados reais, cedidos por uma cooperativa, foram utilizados incluindo informações financeiras, histórico de vendas e comercialização de grãos. O modelo resultante do trabalho tem como objetivo auxiliar os analistas de crédito na priorização dos clientes que deverão ser avaliados e assim e reduzir a inadimplência futura.
Uma abordagem para migração de Banco de dados relacional para NoSQL Orientado a documentos
Authors: Garbin Tainam Spagnollo , Duarte Denio , Schreiner Geomar A. , Feitosa Samuel da Silva
Published: May 2024

A migração de dados de um modelo de banco de dados relacional para um modelo orientado a documentos é complexa e envolve uma série de passos. Este artigo propõe uma metodologia baseada na desnormalização dos dados para realizar a migração de dados do PostgreSQL para o MongoDB. A migração envolve várias etapas, incluindo validação dos dados migrados. Os experimentos revelam que a abordagem é efetiva e a quantidade de chaves estrangeiras impacta significativamente o tempo de migração.
Antimicrobial Susceptibility Patterns of Escherichia coli Isolates from Hospitalized Patients with Different Infections in Isfahan, Iran: Impact on Empiric Antibiotic Therapy in Associated Infections
Authors: Mostafavi Esfahani Sayed Nassereddin , Rostami Soodabeh , Poorshariat Shekoufe
Published: May 2024

Background: Escherichia coli is an important cause of urinary tract, bloodstream, and surgical site infections. Objectives: We investigated the organism's antibiotic susceptibility in hospitalized patients under different clinical conditions. Methods: This prospective study was conducted in three referral hospitals located in Isfahan, Iran. Different clinical samples were tested using standard routine microbiological methods to identify E. coli strains and determine their antibiotic susceptibility patterns by the disk diffusion method according to CLSI recommendations. After conducting a clinical investigation, contaminated samples were excluded, and the hospital or community source and infection site were identified. Data on antibiotic susceptibility testing were extracted using WHONET software. Data analysis was then conducted using SPSS Statistics version 18.0. Results: Of 1248 E. coli isolates, 71.9% were from urine, 15.1% from blood, and 7.8% from skin and soft tissue samples. High susceptibility was observed to Imipenem (98%), Meropenem (98.0%), and Amikacin (94.6%); intermediate sensitivity to Gentamicin (68.6%) and Cefepime (51.9%); and low susceptibility to Ceftazidime (46.8%), Ceftriaxone (41.3%), Ciprofloxacin (39.5%), Cefotaxime (39.3%), and Trimethoprim-sulfamethoxazole (32.4%). Conclusions: Antibiotics, including Imipenem, Meropenem, or Amikacin, would be beneficial in the empiric therapy of severe infections where E. coli is the main cause.
Pelatihan Pembuatan Paving Block Sesuai Standar Mutu SNI di Desa Sukaharja Kabupaten Ketapang
Authors: Sartika Sartika , Herman Herman , Aqla Syarifah , Herkan Afandi Idris , Firman Firman , Indra Septiansyah Sy. Indra Septiansyah , Santi Maya , Mastura Syarifah
Published: May 2024

Paving block merupakan produk bahan bangunan dari semen yang digunakan sebagai alternatif penutup atau pengerasan permukaan tanah. Penggunaan paving block saat ini terus meningkat untuk diaplikasikan pada jalan setapak, trotoar, halaman atau pelataran parkir, dan jalan komplek perumahan. Hal ini dikarenakan paving block mempunyai keunggulan yaitu mudah dalam pemasangannyadan tidak memerlukan alat berat dalam proses pemasangannya. Tim Pengabdi Politeknik Negeri Ketapang akan melakukan pengabdian masyarakat dengan tujuan untuk memberikan pelatihan dan demonstrasi lansung pembuatan paving block sesuai standar SNI kepada masayarakat RT 05 RW 01 Desa Sukaharja Kabupaten Ketapang. Pelaksanaan kegiatan pelatihan diawali dengan sambutan dari Koordinator Program Studi D-III Teknologi Pertambangan, pemaparan materi secara singkat oleh tim PKM dan praktek pembuatan paving block menggunkan alat press. Kegiatan tersebut dilaksanakan di Gang Lobak RT 05 RW 01 kelurahan Sukaharja Kabupaten Ketapang. Ketercapaian tujuan pelatihan dapat dilihat saat penyampaian materi dan praktek pembuatan paving block dimana peserta sangat antusias bertanya dan berdiskusi terkait cara pembuatan serta komposisi yang tepat agar diperoleh paving block berstandar SNI.
Ivan Dmitrievich Popov and His 1806–1808 Expedition to Find a Way to Connect the Ob and Pechora
Authors:   National Park “Yugyd Va” Vuktyl, Russia, Belyaev Andrey
Published: May 2024

The article presents an analysis of historical materials about the expedition of I. D. Popov at the beginning of the 19th century to the Yamal Peninsula and the lower reaches of the Ob and Pechora rivers. It is based on a bibliographic search and research of materials on both the expedition itself and the personality of its leader. The reasons for the organization of the expedition, its tasks, the timing of its conduct, the routes of movement, and the results achieved are shown. Along the proposed routes of the canals, the expedition leveled the rivers, measured the depths, tested the soils, and took transverse profiles. The presence of supply reservoirs on the ground was noted to ensure the operability of the designed water system. Popov compared the organization of the waterway through Yamal and along the Ob-Pechora route. He noted the main advantage of the second option — ships on the way from Siberia to the Arkhangelsk port would not encounter difficult ice conditions in Kara Bay and the Vaygach Strait. Going beyond the technical side of the task of organizing a waterway from Siberia to the European part of the country, Popov points out its critical economic importance for Russia. The author established previously unknown important dates in the life of I. D. Popov, the main stages of his activity, the main projects in which he took an active part and their geography — from the territory of present-day Finland in the west, to the Yenisei basin in the east.
Ethnoecosystems of the Tobolsk Zabolotye: Spatio-Temporal Organization and Sustainability Factors (To a Problem Statement)
Authors:   University of Tyumen, Dirin Denis , Balyuk Natalya ,   University of Tyumen
Published: May 2024

The article is devoted to the topical problem of ethnic ecology, which reflects the peculiarity of the historical development of ethnic groups under the influence of the environment. It analyzes the peculiarities of the formation and functioning of isolated ethno-ecological systems of the traditional type, which have developed in the Tobolsk Zabolotye, the area of residence of the Zabolotnie Tatars — a subethnos of the Siberian Tatars. The regularities of the spatial-temporal organization of these ethnoecosystems and their natural determinism are revealed. The main functional and status zones of ethnoecosystems and the features of their economic use are characterized. Directions for the expeditionary study of the zones of compact residence of the ethnos are indicated. A hypothesis is put forward that ecological and ethnocultural tourism can become one of the ways to diversify the economy, increase the level of well-being of the population while maintaining environmental sustainability and cultural authenticity of local ethnoecosystems.
Documents on the Preparation for Alexander I’s Trip to the Urals in 1824 (To the 200th Anniversary of the Event)
Authors:   Institute of History and Archaeology, Ural Branch of the Russian Academy of Sciences Ekaterinburg, Russia, Shumkin Georgy
Published: May 2024

The publication of the documents is dedicated to the 200th anniversary of Emperor Alexander I’s trip to the Urals in 1824 The Emperor’s interest in this region was not accidental. During the reign of Alexander I, a number of reforms were carried out, during which a system of mining law was created («Draft of Mining Regulations»), the system of state-owned mining districts was institutionalized, a class of indispensable workers was created, and intensive gold mining began. These measures prepared the conditions for the transformation of the Urals into a special region — the Ural Mining Oblast. The publication includes copies of documents from the correspondence of the Zlatoust and Ekaterinburg mining chiefs, deposited in the fund of the Department of Mining and Salt Affairs of the Ministry of Finance of the Russian State Historical Archive. The published materials are devoted to the preparation of the Orenburg province for the meeting of the emperor. The publication of the documents is preceded by an introductory article.
EFFECTS OF VARIOUS FUNGICIDES AGAINST CORYNESPORA CASSIICOLA IN VITRO
Authors: P. MOUNIKA  , S. L. BHATTIPROLU  , S. KHAYUM AHAMMED  , M. SREEKANTH
Published: May 2024

In order to determine the efficacy of eleven fungicides against Corynespora cassiicola causing Corynespora leaf spot of cotton, an experiment was carried out during 2012-22 employing poisoned food technique. The results of radial growth and inhibition of growth over control revealed that variation existed in the sensitivity of C.cassiicola towards different test fungicides. Among the six straight fungicides, carbendazim @ 0.1% and hexaconazole @ 0.2% amended medium promoted zero growth i.e., complete inhibition of C. cassiicola. In propiconazole @ 0.1% amended medium, the growth was 0.9 cm equivalent to 89.7% inhibition. Among the five combination fungicides,fluxapyroxad + pyraclostrobin @ 0.06% and metiram + pyraclostrobin @ 0.3% gave 100% inhibition.
NUTRIENT UPTAKE AND YIELD OF RICE AS INFLUENCED BY DIFFERENT SYSTEMS OF RICE CULTIVATION AND ORGANIC NUTRIENT MANAGEMENT PRACTICES
Authors: K. VINEELA  , D. SUBRAMANYAM  , G. KARUNA SAGAR  , K. V. NAGA MADHURI  , P. SUDHAKAR  , V. CHANDRIKA
Published: May 2024

The field experiment was conducted during late Kharif season of 2021-22 and 2022-23 in splitplot design and replicated thrice to record the nutrient uptake and grain yield as influenced by different organic nutrient management practices under different systems of rice cultivation. Among the different systems of rice cultivation, significantly higher dry matter production, nutrient uptake and yield were noticed under normal transplanted rice which was at par with wet direct seeded rice. Among the organic nutrient management practices tested, significantly higher nutrient uptake as well as yield were obtained with the application of 100% RDN (Recommended Dose of Nitrogen) through poultry manure which was at par with 50% RDN through VC + 50% RDN through poultry manure but both of them were significantly inferior to 100% RDN (120-60-40 kg N, P2O5, K2O ha-1) through inorganic fertilizers on sandy clay loam soils of Southern Agro-Climatic Zone of Andhra Pradesh. Application of 100% RDN through Poultry Manure in transplanted rice was found effective in obtaining higher nutrient uptake and yield than rest of the systems of rice cultivation and organic nitrogen management practices.
STANDARDIZATION AND QUALITY EVALUATION OF WHEAT FLOUR BASED EDIBLE TABLEWARE
Authors: K. RAMMYA MOLU  , E. R. ANEENA  , SEEJA THOMACHAN PANJIKKARAN  , C. L. SHARON  , P. S. LAKSHMY
Published: May 2024

Wheat flour was used in varying proportions ranging between 90% and 40% along with10% to 60% maize flour for the preparation of edible tableware. The best treatment was selected through organoleptic evaluation and textural properties. Among the various combinations, 90 percent wheat flour and 10 percent maize flour was found to be better than other combinations in regards to organoleptic and textural properties. The selected edible tableware was subjected to proximate analysis and observed to have moisture (2.92%), energy (405.98 kcal), protein (13.58 g 100 g-1), fat (3.18 g 100 g-1), carbohydrate (80.76 g 100 g-1), fibre (0.93 g 100 g-1) and total ash (1.56 g 100 g-1). The selected edible tableware was subjected to physico-chemical analysis and observed to have pH (5.28), water absorption index (5.24%), water solubility index (7.76%) and oil absorption capacity (2.20%). The cost of the selected edible tableware was Rs.30.56 per 100 g, which was less than the price of similar products in the market. Biodegradable tableware plays vital role in green marketing for sustainable environment.
INSTITUTIONAL FARM CREDIT– INPUT - OUTPUT TREND ANALYSIS: A STUDY FROM KALABURAGI DISTRICT, KARNATAKA
Authors: MD MOHSIN KHAN  , ANEETTA BENNY
Published: May 2024

This research (2022–2023) examined the impact of institutional credit on farm inputs and output by farmers in Kalaburagi district of Karnataka using the panel data at district level covering the period between 2001 and 2020. The farmers rely heavily on credit mechanisms to modernize their agricultural activities. To assess the functional relationship between agriculture input-output and institutional credit, correlation and multiple regression analysis was conducted. The results showed that modern farm inputs are highly responsive to formal farm credit. An attempt was made to measure the degree and intensity of usage of modern farm inputs with availed credit and its implication on agricultural output in the region. One of the notable results was that farmers’ increased credit capacity has enabled them to procure inputs such as quality seeds, fertilizers, pesticides, and farm mechanization.
Age- and Sex-Dynamic Fluctuations and Reference Intervals for Alkaline Phosphatase Among the Spanish Population
Authors: Castells Vilella Laura , Sánchez-Pintos Paula , Muñiz Llama José Félix , Gámez Martínez Matías , Couce María Luz , Antón Jordi
Published: May 2024

Context.—

Interpretation of alkaline phosphatase (ALP) activity is essential for the diagnosis of certain diseases. ALP changes during life and may vary between different populations.

Objective.—

To establish reference intervals (RIs) and percentile charts for ALP activity in the Spanish population through a multicentric observational study and to compare the RIs to those defined in other countries.

Design.—

A total of 662 350 ALP measurements from individuals ages 0 to 99 years from 9 Spanish tertiary care centers collected between 2020 and 2022 were analyzed. This study is the largest published on this topic in the literature to date.

Results.—

Continuous percentile charts for ALP according to sex and age were established which can be used as RIs. Higher levels are reached during the first weeks of life. In puberty, a differential evolution is observed in both sexes, reaching a peak at 10 to 13 years of age in boys and remaining stable in girls at this age. Significant differences were also observed in adults, higher in men between ages 20 and 49 years and between ages 50 and 79 years in women, as reported in some countries.

Conclusions.—

ALP activity follows an age- and sex-dependent fluctuation with geographic differences. It is important to have appropriate reference values for each population in order to allow for a correct diagnostic interpretation and early diagnosis of diseases related to ALP abnormalities.
Histologic and Quality Assessment of Genotype-Tissue Expression (GTEx) Research Samples: A Large Postmortem Tissue Collection
Authors: Sobin Leslie , Barcus Mary , Branton Philip A. , Engel Kelly B. , Keen Judy , Tabor David , Ardlie Kristin G. , Greytak Sarah R. , Roche Nancy , Luke Brian , Vaught Jim , Guan Ping , Moore Helen M.
Published: May 2024

Context.—

The National Institutes of Health Genotype-Tissue Expression (GTEx) project was developed to elucidate how genetic variation influences gene expression in multiple normal tissues procured from postmortem donors.

Objective.—

To provide critical insight into a biospecimen’s suitability for subsequent analysis, each biospecimen underwent quality assessment measures that included evaluation for underlying disease and potential effects introduced by preanalytic factors.

Design.—

Electronic images of each tissue collected from nearly 1000 postmortem donors were evaluated by board-certified pathologists for the extent of autolysis, tissue purity, and the type and abundance of any extraneous tissue. Tissue-specific differences in the severity of autolysis and RNA integrity were evaluated, as were potential relationships between these markers and the duration of postmortem interval and rapidity of death.

Results.—

Tissue-specific challenges in the procurement and preservation of the nearly 30 000 tissue specimens collected during the GTEx project are summarized. Differences in the degree of autolysis and RNA integrity number were observed among the 40 tissue types evaluated, and tissue-specific susceptibilities to the duration of postmortem interval and rapidity of death were observed.

Conclusions.—

Ninety-five percent of tissues were of sufficient quality to support RNA sequencing analysis. Biospecimens, annotated whole slide images, de-identified clinical data, and genomic data generated for GTEx represent a high-quality and comprehensive resource for the scientific community that has contributed to its use in approximately 1695 articles. Biospecimens and data collected under the GTEx project are available via the GTEx portal and authorized access to the Database of Genotypes and Phenotypes; procedures and whole slide images are available from the National Cancer Institute.
Blended Learning Environments and Student Satisfaction at Kyambogo University
Authors:   Department of Educational Planning and Management, School of Education, Kyambogo University, Kampala, Uganda, KAUTA GRACE , KOMBA RWAKIJUMA LETICIA ,   Department of Educational Planning and Management, School of Education, Kyambogo University, Kampala, Uganda, MUGIZI WILSON ,   Department of Educational Planning and Management, School of Education, Kyambogo University, Kampala, Uganda
Published: May 2024

Student satisfaction (SS) is vital for a positive learning environment, fostering academic success, personal development, and overall well-being. It significantly contributes to longterm success and fulfilment in both chosen careers and beyond. In this study, we focussed our investigation on Kyambogo University (KyU), exploring the influence of a blended learning environment (BLE) on SS, specifically examining the influence of collaboration with peers and learner-centred instructional approaches in BLE. This study was conducted through the theoretical lens of the Community of Inquiry framework by Garrison et al. (2000). The study employed a correlational design with a quantitative approach. Self-administered questionnaires were used to collect data from 619 second-, third-, and fourth-year students. Data analysis utilised descriptive statistics and partial least squares structural equation modelling in SPSS 20 and Smart PLS 4. The findings suggest that students at Kyambogo University express uncertainty regarding collaboration and learner-centred approaches, alongside mixed feelings about their overall satisfaction. However, the study revealed that collaboration and learner-centred instruction had a positive and significant influence on SS, with the BLE contributing substantially (32.23%, adjusted R2 = 0.323) to overall satisfaction. We recommend that KyU prioritises and enhances collaborative learning strategies and learnercentred instructional approaches within its BLE, with the aim to significantly improve SS and overall educational outcomes.
Pathways to Entrepreneurial Culture in Universities: Applying Intrapreneurship Theory to Practice at Kyambogo University
Authors: KITAGAANA ZAIDI
Published: May 2024

The main purpose of this paper was to analyse the in which entrepreneurial culture can be infused in universities. The study adopted the intrapreneurship theory. Universities are being required to operate more entrepreneurially, commercialising the outcomes of their research and spinning out new knowledge-based enterprises. Against this background, the study explored the culture of entrepreneurialism at Kyambogo University, in the Faculty of Engineering. The study attempted to answer the question of how the entrepreneurial culture among academic staff in universities can enhance entrepreneurship. The study adopted a descriptive case study design. Data was collected through one-on-one interview, document analysis and site visit and analysed thematically. The findings show that the existing entrepreneurial elements, such as the promotion of a close relationship with the business community and the promotion of teaching of entrepreneurship, are loosely coupled with one another, and that there is an infant entrepreneurial culture at the faculty. Additionally, the study uncovered a number of impediments to the deepening of an entrepreneurial culture, including bureaucratic procedures, limited incentives, and limited financial and technical support for innovative ideas. It was concluded that: Kyambogo University policies are not fully activated to steer entrepreneurship; infrastructural units at the university lack the bargaining strength to negotiate official licensing contracts with industry; and less attention has been given to deepening analysis of how entrepreneurship is mainstreamed in the university. The study recommended that university management should ensure that entrepreneurial activities are fully integrated into all programmes and actions of the university. The main contribution of this paper is that the findings may help universities to design policies that can stimulate entrepreneurial activities.
Centering Marginalized Voices: Examining Political and Social Rights in Pakistani Elite School Textbooks
Authors: Arjumand Rauf  , Yaar Muhammad  , Amna Yousaf
Published: May 2024

The qualitative content analysis examines the incorporation of human rights education (HRE) in Pakistani citizenship education by examining political and social rights narratives in History textbooks of elite private schools. Utilizing Gagnon and Pagé’s ‘effective system of rights’ framework (1999), this study explored the depth and diversity of rights issue coverage in 13 textbooks. Textbooks show considerable gaps in the representation of rights struggles, exclusion of minority perspectives, and normalization of political repression. This study identified significant differences in rights discourses between elite private schools and IB textbooks. The findings underline the need to diversify narratives on bottom-up rights movements, emphasize socio-economic impacts beyond material losses, and balance global examples with contextualized, relatable accounts of local issues to transform citizenship education for justice.
Finansowe konsekwencje realizacji reformy „Polski Ład” w gminach miejskich na przykładzie gminy Krotoszyn
Authors: Janiak Mateusz
Published: May 2024

Artykuł dotyczy kontrowersyjnej reformy „Polski ład” oraz skutków jej wprowadzenia z perspektywy jednostek samorządu terytorialnego na przykładzie gminy i miasta Krotoszyn. Program „Polski Ład” jest jednym z największych projektów dotyczących finansów publicznych w historii III Rzeczpospolitej Polskiej. Zmiany w formach rozliczania dochodów, zwłaszcza w przypadku podatku dochodowego od osób fizycznych (PIT), są bardzo radykalne. przez co mają znaczenie zarówno dla pracowników zatrudnionych na umowach o pracę, jak i dla przedsiębiorców korzystających z różnych form opodatkowania. Podstawą badań artykułu było zestawienie dochodów i wydatków majątkowych i bieżących a także ich analiza pod względem wielkość oraz dynamiki zmian w ostatnich latach.  Podjęto próbę przeanalizowania, jak wprowadzone reformy, zwłaszcza  dotyczące podatku dochodowego oraz kwoty wolnej od podatku wpłynęły na to jak kształtowała  się struktura budżetu gminy i miasta Krotoszyn w roku 2022., a także plany inwestycyjne.
Wobec niewielu badań nad wpływem Polskiego Ładu na stan finansów JSM, uzyskane wyniki mogą być dobrym punktem wyjścia do dalszych badań.
Pengembangan Dashboard Admin Bukupedia
Authors: Naufal Al Ghazali Muhammad , Azizi Adnan , Khair Ok Syahdan , Saifullah Kusnandar Ziyan Tsabit
Published: May 2024

Di era digital saat ini, pengelolaan platform online yang efektif sangat penting untuk memastikan pengalaman pengguna yang optimal. Bukupedia, sebagai platform perdagangan buku online yang berkembang pesat, memerlukan alat manajemen canggih untuk mengelola konten, memantau kinerja penjualan, dan mengelola pengguna platform secara efektif. Penelitian ini bertujuan untuk mengembangkan dashboard manajemen yang canggih dan intuitif untuk memenuhi kebutuhan manajemen yang efektif dan pengambilan keputusan yang tepat. Metode penelitian yang digunakan meliputi analisis sistem dan pengembangan perangkat lunak menggunakan berbagai alat dan bahasa pemrograman seperti Golang, JavaScript, Postman, XAMPP, Tailwind CSS, GoFiber, dan Visual Studio Code. Penggunaan bahasa pemrograman Golang memberikan keunggulan dalam hal kecepatan, keandalan, dan skalabilitas. JavaScript digunakan untuk meningkatkan tampilan dan interaktivitas halaman web. Postman membantu dalam pengujian dan pengembangan API, sedangkan XAMPP digunakan sebagai server lokal untuk manajemen database. Tailwind CSS digunakan untuk mempercepat pembuatan desain antarmuka dengan menyediakan berbagai utility class. GoFiber dipilih karena kinerjanya yang tinggi dalam pengembangan aplikasi web berbasis fiber. Hasil implementasi menunjukkan bahwa dashboard Bukupedia memberikan tampilan antarmuka yang intuitif dan mudah digunakan oleh admin untuk mengelola data penulis dan naskah. Dashboard ini memungkinkan admin untuk melakukan berbagai operasi CRUD (Create, Read, Update, Delete) dengan efisien. Penggunaan Visual Studio Code sebagai code editor, dan pengujian web pada browser Chrome dan Edge, memastikan bahwa aplikasi yang dibangun berjalan dengan baik sebelum di-deploy ke dalam GitHub Pages. Diharapkan dari hasil penelitian pengembangan  dashboard Bukupedia ini dapat memberikan solusi progresif dalam meningkatkan efisiensi manajemen karya sastra dan pengelolaan penulis, serta membantu Bukupedia dalam membuat keputusan yang lebih cepat dan tepat.
General Approaches to the Formation of a Moral Educational Standard
Authors: Khvostychenko O. M. , Trusei L. H.
Published: May 2024

Based on the analysis of the concept of “spirituality” and related concepts (spirit, soul, ethics, morality, morality, spiritual values, ideals, culture, consciousness, personality, etc.), the author actualizes the creation of a spiritual (moral) standard as a leading component of educational standards at all levels. The basis of the education system should be morality, a moral standard, and its essence should be the purposeful formation of a spiritual core and personality structure in each person (worldview, positivity, self-belief, determination, personal qualities and abilities), and in general — thought-creation and conscious construction of one's destiny, life-creation. That is, the main task of the education system is to teach the younger generation to perceive themselves, others and the world around them and to live in it through a system of universal values and spirituality, since human thinking, motives and actions are linked to the values that prevail in their minds. Considering a person as a system, the author considers the systemic requirements for the development of a moral standard: universality, maximum completeness, efficiency, and scientificity. The author analyzes approaches to the development of a moral standard and suggests directions for its construction based on the key human life goals: development, self-realization, relationships, lifestyle and social activities (serving society — from the earliest stage of human development). This approach takes into account two aspects: on the one side, it may include certain requirements of society for a person, taking into account age and level of development; on the other side, it includes conditions for a person to become happy, realize his or her dreams, and find meaning in life. Development ensures the harmonious improvement of personal qualities and abilities and includes: spiritual (growth of positivity, power of influence, etc.), intellectual (overall academic performance), energy (accumulation of vital energy and physical development — health improvement, growth of energy, physical strength, speed, flexibility, endurance) human development. Self-realization reflects the value of a person to the world through his or her activities in society. Relationships — this indicator should actualize all the best that can be between people: in personal life, in the family, in any team that deserves respect. Partial indicators may include: general ethics of behavior, building relationships, the state of the team (respect, gratitude, mutual assistance), having friends, etc. Lifestyle includes: healthy lifestyle, fullness of life, value of time — living in such a way that joy, inspiration, and enjoyment become almost a normal thing. Recommendations for determining indicators and criteria for evaluating pupils in the areas of moral standard have been developed. An approach to building an evaluation system is presented.
Objective Assessment of Students When Conducting Tests in the Moodle System
Authors: Mandrazhy О. А.
Published: May 2024

The current stage in the development of education around the world is characterized by increasing involvement, and sometimes a complete transition from the traditional system of education to the e-Learning. In such conditions, among other things, the issue of objective assessment of students' achievements in order to obtain real or reliable results of the educational process is relevant. Suppose that we conduct testing among students, consisting of a question on specific knowledge and assuming a choice of either «yes» or «no» answers. Let's assume that in the end it was obtained that 75% of the respondents answered correctly. From this, we can hastily conclude that 75% of respondents know the correct answer, but this is not true. After all, provided that during the test a person was offered specific answers, he could answer, rely not only on his own knowledge, but also, in case of uncertainty or lack of the necessary knowledge at all, simply to choose the answer at random. And most often this is exactly what happens: receiving a test question with answer options for it, it is rare that a person, provided that he does not know the answer, skips the question without choosing anything among the proposed options, most likely he will definitely choose something for good luck. Thus, according to the above example, it cannot be said that three-quarters of the respondents coped, which means that they know the material they asked about, since the percentage of guessers under the described conditions is unknown to us. The object of the research is the Moodle system. The subject of this research is one of the elements Moodle system's course «Test». The paper draws attention to the need to think over such an assessment system when creating tests, which would make it impossible or at least significantly reduce the possibility of passing a test of luck with a high final grade. On the other hand, it is important that the attempt to create a fairer system for calculating the assessment of the test, taking into account those who hope for luck, does not lead to an overly harsh assessment of those who have certain knowledge but have made a mistake, sometimes perhaps a small one.
Transition of Bangladesh Economy to Tiger Economy from Bottomless Economy: A Fifty Years (1972-2022) Perspective
Authors:   Department of Accounting, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh., Uddin Mohammad Main , Das Kana ,   Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj – 8100, Bangladesh. , Sikdar Saruar Alam ,   Institute of Bangladesh Studies, University of Rajshahi, Bangladesh.
Published: May 2024

Since gaining independence in 1971, Bangladesh has made significant economic progress despite starting with the lowest per capita GDP, a weak economy, and inadequate infrastructure. Bangladesh's economy, once dubbed the 'bottomless basket', has recently undergone a significant transformation, gaining recognition as a booming economy, sometimes referred to as the tiger economy. This research aimed to provide a thorough evaluation of the economic growth that Bangladesh has achieved since its independence until the present. Furthermore, this research aimed to analyse the primary obstacles and provide strategies to address them. This study analyses the time series data from 1972 to 2022 for 15 key economic, social, financial, and environmental indicators of Bangladesh's economy. We include the following indicators: annual GDP, GDP growth, GDP per capita, GNI, GNI per capita, trade balance, literacy rate, unemployment rate, carbon (CO2) emissions, life expectancy, access to electricity, external debt, foreign direct investment, total reserves, and annual budget. We obtained the data from the Bangladesh Bureau of Statistics (BBS), the Bangladesh Bank, the Ministry of Finance, and the World Bank. Research findings indicate that Bangladesh has made substantial progress in several economic and social indicators over the last five decades, including high annual GDP, GDP growth rate, GDP per capita, GNI, GNI per capita, literacy rate, life expectancy, access to electricity, foreign direct investment, and the national budget. Although Bangladesh's economy has made significant strides, it still faces many obstacles, including a negative trade balance, a continuously growing unemployment rate, escalating carbon (CO2) emissions, dependence on foreign external loans, a deficit budget, and the need for climate change adaptation. To tackle the difficulties, it is necessary to integrate many proactive measures. This research provides valuable insights for policymakers seeking to comprehend the current patterns of Bangladesh's growth, as well as the significant obstacles it faces and strategies for overcoming them.
Exploring the Nexus: Hierarchy, Identity, and Citizenship Behavior in Prison Organizations
Authors:   Centre of Postgraduate Studies, Asia Metropolitan University (AMU), Malaysia, Men Chenghe
Published: May 2024

This study investigates the interrelationships between hierarchical dynamics, organizational identity, and organizational citizenship behavior (OCB) in prison organizations. Through regression analysis, structural equation modeling, and hierarchical linear modeling, the study validates 11 hypotheses regarding the influence of emotional attachment, personal life integration, and obedience to superiors on organizational identity and OCB. Findings reveal significant positive correlations between emotional attachment, obedience to superiors, organizational identity, and OCB. Team cohesion moderates the relationship between organizational identity and individual-oriented OCB. The mediating role of organizational identity is evident in the relationship between hierarchical dynamics and OCB. The study underscores the importance of fostering positive leader-member relationships and promoting organizational cohesion to enhance employee engagement and performance.