bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a Figure of Merit for the Optimisation of Antennas for the X-Band All Sky Survey
Authors: Kriel Scott Graham Hilton , de Villiers Dirk Izak Leon
Published: March 2023

The X-Band All-Sky Survey (X-BASS) is a planned radio astronomy experiment aimed at mapping the sky in both temperature and polarisation. The main purpose of X-BASS is to aid observations of the cosmic microwave background (CMB) by removing various contaminating foreground emissions present in the galaxy, such as synchrotron and thermal dust emissions. When designing the antenna for such an instrument, one must rely on traditional figures of merit (FoMs) used to describe the performance of antenna radiation pattern characteristics. However, these FoMs often have a conflicting nature, the optimal trade-off of which may not be immediately apparent. What is more, traditional FoMs are usually developed from a telecommunications standpoint or determined heuristically from other radio astronomy projects with differing goals. Thus, the exact effect of antenna pattern characteristics on the end science goals of the experiment may be unclear. As such, this paper seeks to determine the limitations posed by antenna noise temperature, beamwidth and cross-polarisation on the end science goal of the experiment, which is the determination of various cosmological parameters through observation of the CMB. From this, a new FoM was developed which provides a single metric to be used in the optimisation of the antenna structure. This FoM was then used in the preliminary design of a corrugated horn antenna to feed the X-BASS reflector system.
New STEP-NC compliant system to Automatic Process Planning for Turning Process
Authors: Elmesbahi Abdelilah , Buj-Corral Irene , Mesbahi Jihad EL , Bensaid Oussama
Published: March 2023

STEP-NC is a smart standard, developed by the International Standard of Organization ISO, to substitute the ISO 6983 G-code, because, the language G-Code, normally used for Computer Numerical Control (CNC), is qualified to be not able to links CAD/CAM/CNC digital chain and ensure the exigencies of modern intelligent manufacturing in terms of tractability, interoperability, flexibility, adaptability, and extensibility. Therefore, the first objective of this paper is to design and implement a Computer Automatic Aided Process for Turning process, designated by CAPP-Turn, to ensure machining of rotational parts within this modern vision. However, to achieve CAPP-Turn system, it is compulsory to build a robust Automatic Manufacturing Features Recognition AMFR module to establish a full communication between the first two links of the digital chain which are Design CAD and Manufacturing CAM. that's why, by using a hybrid graph-rules method, the second objective of this works is focused on elaboration of a new consistent-fast algorithm that allow extraction of the machining turning entities for parts with most efficiency and complex geometry. In fact, in the literature, most of the presented AMFR systems are restricted of external turning process and cannot handle parts with complex geometry and interacting features. Moreover, the frontal turning features are almost neglected in most of these systems, despite their importance for fulfilling certain functions in mechanical systems. This article, in first, details the global architecture of the CAPP-turn and describe clearly trades between the CAD part and STEP-NC output file. In second, it explains model of the Automatic Manufacturing Feature Recognition (AMFR) system. This system encompasses: (i) a parser module that translates geometric and topological data, from STEP AP203 CAD file, into Python entity class’s objects; (ii) an AMFR that analyses the created-objects and applies predefined-rules to construct all possible turning machining (iii) a Module capable to select external features from internal, frontal features from axial and handle interacting features from the simples. Afterwards, these steps, the AMFR gives all suitable sequencings for part machining. At the end, with a goal to demonstrate the potential advantages and power of proposed the proposed AMFR, a selective part is chosen for the test. The result shows that AMFR performs well on recognizing all types of features indifferently of their types: Internal or external, axial or frontal, simple or interacting.
Weighted weak estimate for commutators of fractional Marcinkiewicz integrals over non-homogeneous metric spaces
Authors: Tao Xiangxing , Feng Shuaijun
Published: March 2023

Let (X, d, μ) be a non-homogeneous metric measure space, which satisfies the geometrically doubling condition and the upper doubling condition. In this paper, under the assumption that the fractional Marcinkiewicz integral operator Mβ,ρ,q is bounded on L2(X, μ), the authors prove the weak type weighted Lp(ω) boundedness of the commutators Mbβ,ρ,q with the RBMO(μ) function b.
MSC: 42B20; 42B25
Suffering in Silence. Population-Level Detection and Risk-Prediction of Women’s Reproductive Disease from Claims Data
Authors: Rudinac Maja , Moirogiannis Dimitrios , Baker Katie , Makridakis Thodoris , Atsonios Ioannis
Published: March 2023

We present a new approach to population health where data-driven predictive models are learned for various stigmatized, underserved, and neglected chronic conditions that affect women. Our approach enables early detection within large populations at low cost from readily available medical claims datasets. The model uncovers early and late stage risk factors up to two years in advance of onset that can be used as guides for early interventions for endometriosis, polycystic ovarian syndrome, and infertility, allowing women suffering from these conditions to get on treatment plans earlier.
Regulatory Effects and Mechanism of Immune Inhibitory Receptor LAIR-1 in Non-small Cell Lung Cancer
Authors: Yu Shuo , Yu Ruoxi , Liu Dan , Song Weikang , Duan Xuming , Sun Deyu , Qu Yanli
Published: March 2023

Purpose To investigate the association of leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) levels with clinicopathological features and prognosis of non-small cell lung cancer (NSCLC).
Methods The expression of LAIR-1 and clinicopathological data were downloaded from The Cancer Genome Atlas database and Gene Expression Omnibus for analyzing the correlation between LAIR-1 expression and prognosis. Tissue samples from 118 NSCLC patients and 47 paired adjacent cancer tissues were collected and the expression of LAIR-1 in NSCLC tissues was detected by immunohistochemistry. The statistical analysis was performed for association analysis of LAIR-1 expression and clinicopathological properties. Lentiviral transfection of NSCLC cell lines A549 and SK-MES-1 for overexpressing LAIR-1 were used to evaluate the role of LAIR-1 in regulating cell cycle and apoptosis in NSCLC cell lines by flow cytometry.
Results LAIR-1 expression was lower in NSCLC tissues than in para-cancerous tumor tissues, and overall survival time was lower in the LAIR-1 low- expression group. Univariate analysis revealed that the low expression of LAIR-1 was related to lymph node metastasis, tumor stage, etc. in NSCLC patients. The LAIR-1 low-expression group of the NSCLC patients showed higher mortality, tumor progression, and lower overall survival and disease-free survival. Multivariate analyses demonstrated that the expression of LAIR-1 in squamous carcinoma patients had a negative correlation with NSCLC progression. In vitro experiments showed that the overexpression of LAIR-1 blocked the squamous cell carcinoma at the G1 stage and promoted cell apoptosis.
Conclusion LAIR-1 was closely associated with lymph node metastasis, tumor stage, and patients’ prognosis.
Causes and Effects of Project Delay in Public Construction Projects in Ethiopia
Authors: Seman Abdilkerim Asrar , Ahmed Hamed M. S. , Ahmed Abubeker , Haso Abdurahman Awel
Published: March 2023

Projects especially public construction projects have a vital role for the economic development of a nation by transforming the living standard of the community. This study aimed to assess the causes and effects of public construction projects in Dessie town. To achieve the objective of the study 128 respondents approached from the clients, contractors and consultants of the ongoing projects of Dessie town. Questionnaires used to collect primary data from the target population. It has both a likert scale and open ended items. The collected data were analyzed using descriptive data analysis techniques along with the relative importance index. The index widely used in similar studies to measure the level of importance and occurrence of delay causes and effects. The findings of the study showed that the causes of delays emanated from clients, contractors, consultants and externals. Furthermore the main responsible stakeholder for delay of projects in Dessie town is clients. In addition the top ranked causes are delay of progress payment by clients, poor communication and coordination by contracting parties, slowness of the decision making process by owners and financial difficulties of stakeholders. Regarding to the effects of delay, time overrun cost overrun, total abandonment, dispute, litigation, poor project quality, negotiation and bad public relation are confirmed. Based on the findings, the study recommends clients the so called public agencies to revise their project management system, improve financial management system and need to ensure regular project monitoring and evaluation. In addition the study also recommends corrupted individuals should be identified and accountable legally.
Microglial depletion and repopulation did not affect hippocampal neurogenesis after whole brain irradiation
Authors: Zhou Kai , Zisiadis Georgios Alkis , Havermans Monique , Dominguez Cecilia , Ohshima Makiko , Rodrigues Carlos F. D. , Blomgren Klas
Published: March 2023

Background
Ablation of hippocampal neurogenesis is thought to be one reason behind the lifelong cognitive complications that childhood brain cancer survivors face after cranial radiotherapy. Microglia react strongly immediately after an irradiation insult, promoting a neuroinflammatory microenvironment that can prove detrimental for the neurogenic niche. The depletion and repopulation of microglia as a therapeutic strategy was recently shown to ameliorate cognitive deficits in a traumatic brain injury model, but this approach has not been explored in the context of hippocampal neurogenesis after radiation therapy.
Methods
Cx3cr1 CreERt2 − YFP/+ Rosa26 DTA/+, a transgenic mouse model that allows for endogenous expression of diptheria toxin A in targeted cells in a Cre-mediated manner was utilised to deplete microglia from the brain. Postnatal day 18 (P18) mice were injected with tamoxifen for 3 consecutive days to activate the Cre recombinase and were then subjected to an 8 Gy single dose of cranial irradiation on P21. The numbers of proliferating cells and immature neurons were assessed through quantification of Ki67+ and DCX+ cells.
Results
In Cx3cr1CreERt2 − YFP/+Rosa26DTA/+ transgenic mice, microglia could be 97% depleted, remained absent for at least 7 days, and had fully repopulated the brain 10 days after three tamoxifen injections. Following irradiation, the lack of microglia led to delayed removal of cellular debris. Microglia depletetion itself caused increased concentrations of CCL2, presumably to recruit bloodstream monocytes, and irradiation caused synergistically higher and sustained levels of CCL2 compared to controls. The absence of microglia at the time of irradiation did not affect neurogenesis, as judged by the numbers of Ki67+ and DCX+ cells, neither 7, nor 10 days after the last tamoxifen injection, when microglia were still absent or had repopulated, respectively. Lastly, long-term assessment of neurogenesis, 6 weeks after irradiation, as judged by Ki67+ and DCX + cells and granule cell volume, was not different between micoglia depleted and control mice.
Conclusions
The transgenic mouse model described here is an effective tool to study the effects of microglia depletion.Microglia depletion prior to cranial irradiation did not rescue neurogenesis, neither short-, nor long-term, possibly, at least partly, because of the increased levels of CCL2.
Comparative Analysis of Applying Imputation and Hyperparameter Optimization in Cancer Diagnosis
Authors: Wang Haibo , Liu Yi , Wang Wendy
Published: March 2023

Cancer is one of the leading causes for death worldwide, accurate and timely detection of cancer can save lives. With more machine learning algorithms and approaches have been applied in cancer diagnosis, there is a need to analyze their performance. This study has compared the detection accuracy and speed of twenty-one machine learning and deep learning algorithms on a cervical cancer dataset. To ensure the system can potentially be applied to other types of cancers, this study has taken all features into consideration and has examined the impact of imputation and hyperparameter optimization on these algorithms’performance. The results suggest that when both imputation and hyperparameter optimization are applied, over 70% of the algorithms have improved their accuracy, among which support vector machine performs the best, with the trade-off that the execution time for most algorithmshave been lengthened. Such performance is better than when imputation or hyperparameter optimization is applied individually, and when both are absent. By not including feature selection process that most systemswould employ, this study shows such system can achieve satisfactory performance while potentially can be used to detect various types of cancers.
Predictive value of coronary artery computed tomography-derived fractional flow reserve for cardiovascular events in patients with coronary artery disease
Authors: Han Hongwei , Liu Meijun , Yu Yang , Chen Yuan , Xu Yizhou
Published: March 2023

Background: Coronary computed tomography-derived fractional flow reserve (FFR-CT) assesses whether coronary artery lesions will result in myocardial ischemia.
Aim: This study aimed to evaluate the predictive value of FFR-CT for cardiovascular events in patients with coronary artery disease (CAD).
Methods: Data were collected retrospectively from patients with CAD who underwent FFR-CT at our hospital from January 2020 to February 2022 (1-year average follow-up). Patients were divided into ischemic (FFR-CT ≤ 0.80) and non-ischemic (FFR-CT > 0.80) groups. The incidence of endpoint events (cardiac death, acute myocardial infarction, unplanned revascularization, unstable angina, and stable angina) was calculated. The FFR-CT value was correlated with endpoint events using Cox regression models and Kaplan-Meier survival curves.
Results: We recruited 134 patients (93 [69.4%] and 41 [30.6%] patients in the ischemic and non-ischemic groups, respectively). Compared to the non-ischemic group, the ischemic group had a higher proportion of men, patients with type 2 diabetes and hypertension, and patients taking antiplatelet drugs and β-blockers (all P < 0.05). Other parameters were comparable. Multivariate Cox regression analysis revealed no significant differences between the groups for cardiac death, acute myocardial infarction, unplanned revascularization, and unstable angina; the incidence of stable angina events (HR=3.092, 95% CI: 1.362–7.022, P = 0.007) was significantly higher in the ischemic group. Kaplan-Meier survival analysis identified a significant difference in event-free survival for stable angina between the groups (P = 0.002).
Conclusion: FFR-CT showed an independent predictive value for stable angina within 1 year of examination in patients with CAD.
The causal relationship between cheese intake and peripheral vascular disease: A two-sample mendelian randomization study
Authors: wen song , HUANG Zehan , HE Guodong , ZHANG Bin , HUANG Yuqing
Published: March 2023

Background
Previous observational studies have yielded inconclusive findings regarding the potential association between cheese intake and peripheral vascular diseases (PVDs). We sought to systematically investigate the causal link between cheese intake and PVDs.
Methods
A two-sample mendelian randomization (MR) investigation was undertaken to evaluate the causal link between cheese intake and PVDs. This MR analysis relied on summary statistics derived from genome-wide associations of cheese intake (N=451,486) and an array of PVDs, including peripheral artery disease (PAD) (N=1,230 cases, 59,964 controls), peripheral vascular disease (PVD) (N=1,456 cases, 461,554 controls), peripheral angiopathy (N=193 cases, 162,201 controls), aortic dissection (N=470 cases, 218,322 controls), aortic aneurysm (AA) (N=2,825 cases, 215,967 controls), other peripheral vascular diseases (N=1,037 cases, 217,755 controls), pulmonary embolism (PE) (N=1,846 cases, 461,164 controls), deep vein thrombosis(N=6,795, not available cases/controls), and arterial embolism and thrombosis of lower extremity artery (N=471 cases, 218,321 controls). The primary outcome of the study utilized inverse variance weighted (IVW) MR analysis, with weighted median, MR Egger, and weighted mode methods serving as complementary analyses to IVW. Moreover, the results were robustly examined through a sensitivity analysis.
Results
Genetically predicted cheese intake was not associated with peripheral artery disease [odds ratio (OR) = 1.00, 95% confidence interval (CI): 1.00–1.00, P = 0.953], peripheral vascular disease (OR = 1.00, 95% CI: 0.99–1.00, P = 0.265), peripheral angiopathy (OR =0.56, 95% CI: 0.09–3.66, P = 0.566), aortic dissection(OR = 0.69, 95% CI: 0.19–2.55, P = 0.583), aortic aneurysm(OR = 0.92, 95% CI: 0.46–1.82, P = 0.809), other peripheral vascular diseases(OR = 0.99, 95% CI: 0.44–2.21, P = 0.979), pulmonary embolism(OR = 1.00, 95% CI:1.00–1.00, P = 0.635), deep vein thrombosis(OR = 0.83, 95% CI: 0.62–1.12, P = 0.229), and arterial embolism and thrombosis of lower extremity artery(OR = 0.69, 95% CI: 0.21–2.29, P = 0.5413).
Conclusion
Based on the results of our two-sample MR analysis, we found no significant association between cheese intake and the risk of PVDs, including peripheral artery disease, peripheral vascular disease, peripheral angiopathy, aortic dissection, aortic aneurysm, other peripheral vascular diseases, pulmonary embolism, deep vein thrombosis, and arterial embolism and thrombosis of lower extremity artery.
One day interruption of NOAC is associated with low risk of periprocedural adverse events during pulmonary vein isolation if combined with left atrial thrombus exclusion with computed tomography
Authors: Piros Katalin , Vida Adorján , Szegedi Nándor , Perge Péter , Salló Zoltán , Ferencz Arnold Béla , Nagy Vivien Klaudia , Herczeg Szilvia , Ábrahám Pál , Csobay-Novák Csaba , Drobni Zsófia , Tahin Tamás , Apponyi Györgyi , Merkely Béla , Gellér László , Osztheimer István
Published: March 2023

Purpose: Safety, efficacy, and patient comfort are the primary expectations during pulmonary vein isolation (PVI).
We aimed to validate the combined advantages of pre-and periprocedural anticoagulation with non-vitamin K anticoagulants (NOACs) and rigorous left atrial appendage thrombus (LAAT) exclusion with computed tomography (CT). Moreover, we assessed the effect of pre-and periprocedural workups and the catheter ablation on the patients' quality of life.
Methods: Consecutive patient population was collected between March 2018 and June 2020, who underwent cardiac CT within 24 hours before PVI to plan and guide the ablation and rule out LAAT. NOAC was omitted 24 hours before the ablation. If CT was inconclusive regarding the presence of a thrombus, transoesophageal echocargiography (TOE) was performed. All patients underwent PVI using point-by-point radiofrequency ablation. All patients had a routine follow up at 3 months. Quality of life questionnaires were obtained postprocedurally to evaluate the periprocedural discomfort of the patients.
Results: 187 patients (63% male) underwent CT before PVI. TOE was used in 11 (6%) cases. None of the patients experienced stroke during or after the procedure. Based on the quality of life questionnaires, the worst patient discomfort was caused by atrial fibrillation itself, followed by the TOE, then the ablation procedure, hospital stay, and finally the CT. Complication rate was low, with no symptomatic thromboembolic event and 2.1% major bleeding event.
Conclusion: Omitting NOAC 24 hours before the ablation might be safe. Moreover, patient comfort may be increased by replacing the TOE examination with CT.
Combination of Steroid and Anticoagulant Therapy to Treat Acute/Subacute Severe Cerebral Venous Thrombosis
Authors: Zhou Chen , Zhao Tingyu , Guo Yansu , Hu Shuyuan , Zhang Kaiyuan , Li Jingkai , Gu Yaqin , Ji Xunming , Duan Jiangang
Published: March 2023

Background: Accumulating evidence suggest that the inflammatory response plays a vital role in regulatingsevere CVT pathogenesis. However, whether CVT patients can benefit from anti-inflammatory therapy has been debated. This study explored the potential efficacy and safety of steroid combined with anticoagulant therapy in acute/subacute severe CVT patients.
Methods: We reviewed the data of patients with acute/subacute severe CVT treated with a short-term application of steroid or not from a prospective stroke registry of our center. We compared functional outcomes and major adverse events at 6 months follow-up after discharge using the propensity score matching method(PSM).
Results: A total of 248 acute/subacute severe CVT patients were eligible for this study. After PSM, there were 85 patients in the steroid group and 85 in the nonsteroid group. Compared with the nonsteroid group, the steroid group had a higher likelihood ofmRS(0-2)(85.88% versus 75.29%, P=0.03) and a lower likelihood of residual headache(19.28% versus 47.50%, P=0.01) at 6 months follow-up after discharge. Multivariable logistic regression analysis shows steroid treatment(OR 4.69, 95% CI 1.63-13.48, P=0.01) was associated with the favorite outcome in the matched cohort. Regarding steroid safety, the likelihood of CVT recurrence, lower extremity deep venous thrombosis, pulmonary embolism, infection and mortality did not differ significantly(P＞0.05) between the steroid and nonsteroid groups.
Conclusion: The findings suggest that short-term use of steroid might be an effective and safe adjuvant therapy for acute/subacute severe CVT under standard anticoagulant treatment. However, the findings need to be further verified using prospective research.
Investigating the interaction of azobenzene moiety on the amino acid tryptophan
Authors: Frederic Charnette , Wiedman Gregory R.
Published: March 2023

Molecular photoswitches are a series of compounds that can be isomerized upon irradiation with light. Photoswitchable molecules can modify the physical, chemical, and biological properties of a diverse range of materials. They can control protein structure and function with temporal and spatial precision. In this work, we investigated the possible interaction between azobenzene and aromatic amino acids. We hypothesized that aromatic amino acids, such as tryptophan, would show altered photochemical properties when conjugated with azobenzene. When irradiated at either 365 nm or 465 nm, the photo-switching behavior favors the cis isomer and is visibly fluorescent at 365 nm. To our knowledge, this is the first evidence to suggest that primary protein structure could affect photoswitch activity. The knowledge gained from this research will help to further the understanding of photoswitches as they are used in biomolecules.
Modeling the Factors Affecting the Adoption of Electric Vehicles Technology with A Machine Learning Approach
Authors: hedayati sadaf
Published: March 2023

Electric and hybrid vehicles prove to be a good solution to reduce the use of fossil fuels and environmental and air pollution. The purpose of the study was to model the factors that affect the adoption of electric vehicle technology (EVT) using a machine learning approach. To this end, the study data were collected using the library method and examining the sources and internet studies. A questionnaire was prepared to measure the effective variables and distributed among 688 people in the virtual space to ensure the validity and reliability of the measurement tool. The obtained data were analyzed using the machine learning tool and the hierarchical clustering algorithm,and the potential buyers of electric vehicles in Iran were divided into five clusters based on the hierarchical clustering. Each cluster has its behavioral traits, making it distinct from other clusters. The people in cluster three characterized the group of society, among whom hybrid vehicle technology is more accepted than the others, and this cluster must be targeted, and policies must be adopted to expand this cluster to expand the adoption of hybrid vehicle technology in Iran. Technology being updated is critical for the people of this cluster - the vehicle design and the reliable brand are effective factors in their choice while buying a vehicle. The variety of hybrid vehicle branded in Iran is considered an effective factor in the wider acceptance of this technology in Iran. The limited selection of these vehicles and the poor after-sale service of their batteries are obstacles to the development of these vehicles in Iran.
Exudyn – A C++ based Python package for flexible multibody systems
Authors: Gerstmayr Johannes
Published: March 2023

The present contribution introduces the design, methods, functionalities and capabilities of the open source multibody dynamics code Exudyn, which has been developed since 2019. The code has been designed for rigid and flexible multibody systems, with focus on performance for regular multi-core CPUs. It includes script language based modeling and it is intended to be used in science and education, but also in industry. The open source code is available on GitHub and consists of a main C++ core, a rich Python interface including pre- and post-processing modules in Python,and a collection of rigid and flexible bodies with according joint, load and sensor functionality. Integrated solvers allow explicit and implicit time integration, static solution, eigenvalue analysis and optimization. In the paper, the code design, structure, computational core, computational objects and the multibody formulations are addressed. In addition, the computational performance is evaluated with examples of rigid and flexible multibody systems. The results show the significant effect of multithreading even for comparatively small systems as well as for larger models.
Rule-Based Automatic Question Generationusing Dependency Parsing
Authors: Sewunetie Walelign Tewabe , Laszlo Kovacs
Published: March 2023

Artificial intelligence systems offer valuable support to the education sector by automating routine tasks for instructors and providingadaptive assessments. These assessments are a crucial component ofautomatic question-generation techniques. There are various techniquesfor question generation described in the literature. This paper introduces a novel rule-based system for automatic question generationthat employs dependency parsing techniques. The proposed methodfocuses on analyzing both the syntactic and semantic structure of asentence. The paper includes both manual and automatic evaluationmetrics to assess the questions generated by our proposed system. Inthe evaluation, our system received an overall score of 3.67 out of5.0 for human-level performance, an average BlEU−N score of 0.718,and F1−score scores above 0.5 for all types of ROUGE. Both humanand automatic evaluation results demonstrate that our proposed system achieves good performance on simple and short sentences. In thefuture, we plan to enhance our model by incorporating phrase-levelparsing to further improve the proposed dependency parsing techniques.
A new electrolyte based on magnetic ionic liquid with magnetic-tuning electrochemical performance
Authors: Zhang Zhengguo , Li Xiaolin , Fang Yurui , Gao Miao , Liu Zixuan , Liu Qichao , Gu Ning , Cao Yang
Published: March 2023

A new magnetic ionic liquid (MIL) based on 1-methylethyl ether-3-butylimidazole and [FeCl4]− is synthesized for application in electrolyte. It is found that the electrochemical performance of magnetic ionic liquid based mixed electrolyte can be improved by applying magnetic field. The enhanced electrochemical performance is attributed to the formation of microdomain in the mixed electrolyte under magnetic field. The ions of MIL can align along the direction of the magnetic field, providing the efficient transmission path for the migration of Li+ and Cl−. Under magnetic control, the MI-based electrolyte does not only retain its wide electrochemical window characteristics, but also solves the problem of limiting the high viscosity of IL as electrolyte. The work provides a new method to design and prepare high-performance electrolyte for various electrochemical applications.
Comparative metabolomic analysis of human cancellous bone reveals the critical role of linoleic acid metabolism in femur head necrosis based on GC-MS
Authors: Zhu Weiwen , Wang Rui , Luo Xuming , Yang Zhijian , Yu Baoxi , Zhang Jian , Fu Ming
Published: March 2023

Introduction
Femur head necrosis (FHN) is a challengeable clinical disease with unclear underlying mechanism and a low rate of early diagnosis.
Objectives
To elucidate altered metabolism pathways in FHN and identify putative biomarkers for the detection of FHN.
Methods
we recruited 26 patients with femur head necrosis and 22 patients with femur neck fracture in this study. Cancellous bone tissues from the femoral heads were collected after the surgery and were analyzed using an untargeted metabolomics approach on the basis of gas chromatography-mass spectrometry (GC-MS).
Results
The resulting data were analyzed via uni- and multivariate statistical approaches, and we identified 38 metabolites distinctly changed in FHN group. Among them, 33 metabolites were upregulated and 5 were downregulated in FHN. The pathway analysis results showed that linoleic acid metabolism were the most relevant to FHN pathology. On the basis of metabolites network, L-lysine, L-glutamine and L-serine were deemed as the junctions of the whole metabolites. At last, we figured out that 9,12-octadecadienoic acid, inosine, L-proline and octadecanoic acid can be considered as the potential biomarkers of FHN.
Conclusion
Our study provided a new insight into the pathogenesis of FHN and identified 4 biomarkers in FHN. Linoleic acid metabolism could be considered as the core in FHN and 9,12-Octadecadienoic acid could be considered as the diagnostic marker.
Role of Parents in the Gender Role Identity Formation of Offspring- An Exploratory Study.
Authors: Chowdhury Shreya , Bhattacharya Suvosree , Bhattacharya Surajit , Bhattacharya Anjan
Published: March 2023

Gender role identity tends to shape an individual’s self-concept, playing a significant role in shaping their behaviour and interpersonal relationship patterns across different societies, races, and ethnicities. This study explores the relationship between perceived parenting styles (authoritarian, authoritative, and permissive for both parents) and gender role identity in young adults, and also the pattern of gender role identity of parents and their offspring. The sample consisted of 100 young adults (M=20.60, SD=1.98) and both of their parents (father and mother). Both the young adults and their parents responded to the Bem Sex-Role Inventory, whereas only young adults responded to the Parental Authority Questionnaire. Descriptive statistics showed that out of 100 young adults, 38% identified as androgynous, followed by feminine (29%), masculine (12%), and undifferentiated (21%). 54% of male young adults rated themselves as androgynous, whereas 46% of females identified as feminine. A considerable proportion of the parents reported themselves as androgynous (both 48%). A significant correlation was found between permissive parenting style in mothers and undifferentiated gender role identity in young adults (r= 0.75, p= 8.1e-05). A positive, moderately significant correlation was also found between fathers' permissive parenting style and masculinity in young adults (r= 0.83, p= 0.00093). This information will help us understand parents' role in gender identity formation and may also help us formulate management plans in terms of the parent-child relationship and their gender role identity.
On the Consistent Construction of Ipsative Tests
Authors: Vaughan Martin Paul , Demes Kali A , Glowinkowski Steve Paul
Published: March 2023

The need for consistent construction of ipsative tests to avoid the introduction of hard-coded `errors-by-design' is highlighted A set of necessary criteria for consistent construction is found and recommended. It is shown that for ipsative tests involving P scales with more than M=2 comparisons per item, the consistent combinations of P and M are in fact few and far between for tests with a manageable numbers of items. The introduction of errors through badly designed scoring methods is also illustrated and explained via analysis.
Prognostic value of post-operative inflammatory biomarkers in colorectal cancer patients: Systematic Review and Meta-Analysis.
Authors: Gwenzi Tafirenyika , Zhu Anna , Schrotz-King Petra , Schöttker Ben , Hoffmeister Michael , Edelmann Dominic , Brenner Hermann
Published: March 2023

Background
Post-operative inflammation in cancer patients can be modulated by drugs and diets, but evidence on its prognostic role, which would be crucial for personalized treatment and surveillance schemes, remains rather limited.
Aim
To systematically review and meta-analyse studies on the prognostic value of post-operative C-reactive protein (CRP)-based inflammatory biomarkers among patients with colorectal cancer (CRC) (PROSPERO#: CRD42022293832).
Methods
PubMed, Web of Science and Cochrane databases were searched until February 2023. Studies reporting associations between post-operative CRP, Glasgow Prognostic Score (GPS) or modified Glasgow Prognostic Score (mGPS) with overall survival (OS), CRC-specific survival (CSS) and recurrence-free survival (RFS) were included. Hazard ratios (HRs) with 95% confidence intervals (CIs) for the predictor-outcome associations were pooled using R-software, version 4.2.
Results
Sixteen studies (n = 6,079) were included in the meta-analyses. Elevated post-operative CRP was a predictor of poor OS, CSS and RFS compared with low CRP levels [HR (95%CI): 1.72 (1.32–2.25); 1.63 (1.30–2.05); 2.23 (1.44–3.47), respectively]. A unit increase in post-operative GPS predicted poor OS [HR (95% Cl): 1.31 (1.14–1.51)]. Moreover, a unit increase in post-operative mGPS was associated with poor OS and CSS [HR (95% Cl): 1.93 (1.37–2.72); 3.16 (1.48–6.76), respectively].
Conclusion
Post-operative CRP-based inflammatory biomarkers have a significant prognostic role for patients with CRC. Prognostic value of these easy-to-obtain routine measurements thereby seem to outperform most of the much more complex blood- or tissue-based predictors in the current focus of multi-omics-based research. Future studies should validate our findings, establish optimal time for biomarker assessment and determine clinically useful cut-off values of these biomarkers for post-operative risk-stratification and treatment-response monitoring.
Tarifverträge für Selbstständige und ihre Vereinbarkeit mit dem EU-Wettbewerbsrecht
Authors: Nefiz Caner
Published: March 2023

Im Rahmen des Tarifvertragsrechts spielen Selbstständige eine nur untergeordnete Rolle – so schien es zumindest in der Vergangenheit die Regel gewesen zu sein. Während das Tarifvertragsgesetz in seiner ursprünglichen Fassung von 1918 (TVVO) nur Arbeitnehmer im Blick hatte, wurde der persönliche Anwendungsbereich mit Einführung des § 12a TVG auf arbeitnehmerähnliche Personen ausgedehnt, wobei der restriktiv ausgelegte Anwendungsbereich und die Auswirkungen in der Praxis zeigten, dass hierdurch keine umfassende Erweiterung des Tarifvertragsrechts auf Selbstständige erreicht werden würde. Nunmehr steht das Arbeitsrecht, auch in Hinblick auf Überschneidungen mit dem Kartellrecht, vor der Herausforderung, sich auf sich ändernde Arbeitsformen und neue wirtschaftliche Gegebenheiten anzupassen, um in Zukunft auch andere Personengruppen von seinem Schutze zu erfassen. Dass es sich hierbei nicht um eine rein nationale Angelegenheit handelt, zeigt der Wandel des politischen und rechtlichen Diskurses auf Unionsebene.
anti-suit injunctions und ihre Vereinbarkeit mit dem europäischen Zivilprozessrecht
Authors: Kopelev Valentin
Published: March 2023

Die vorliegende Arbeit untersucht die Zulässigkeit von sog. anti-suit injunctions im Anwendungsbereich der EuGVVO. Dabei wird anhand der Antworten des Europäischen Gerichtshofs auf Vorlageersuchen zu den Rechtssachen Turner v. Grovit und West Tankers v. Allianz/Generali herausgearbeitet, dass der Grundsatz des gegenseitigen Vertrauens der Mitgliedstaaten in die Funktions- und Leistungsfähigkeit der Rechtssysteme und Rechtspflegeorgane zu einer Inkompatibilität von anti-suit injunctions mit der EuGVVO führt. In einem weiteren Schritt folgt ein kursorischer Überblick über die aktuellen Entwicklungen im deutschen Prozessrecht rund um die sog. anti-anti-suit injunction. Abschließend wird die Frage nach der Aktualität des Rechtsmittels näher beleuchtet und unter besonderer Berücksichtigung des Brexits bestätigt.
Das neue Beschlussmängelrecht der Personengesellschaften nach dem MoPeG
Authors: Kästle Vincent
Published: March 2023

Der Gesetzgeber hat sich im Personengesellschaftsrechtsmodernisierungsgesetz (MoPeG) dazu entschieden, für Personenhandelsgesellschaften ein Beschlussmängelrecht nach dem Vorbild des AktG einzuführen (sog. Anfechtungsmodell). Bei den übrigen Personengesellschaften, insbesondere bei der GbR, bleibt es hingegen bei den allgemeinen rechtsgeschäftlichen Regeln (sog. Feststellungsmodell). Der Beitrag stellt die Neuregelung vor und beurteilt die Vor- und Nachteile der beiden Modelle. Das Ergebnis der Untersuchung ist, dass die Einführung des Anfechtungsmodells für Personenhandelsgesellschaften zu loben und gut gelungen ist, beim Feststellungsmodell allerdings noch Verbesserungspotenzial besteht.
Determination of phenotypic stability of quantitative morphological features and economic value characteristics of sweet potato tubers (Ipomoea batatas L.)
Authors: Semenenko S. V. , Leshchuk N. V. , Orlenko N. S. , Symonenko N. V. , Pavliuk N. V.
Published: March 2023

Purpose. To justify the use of the Lewis phenotypic stabi­lity factor (SF) to determine the stability of the manifestation of quantitative and economic value characteristics of national varieties of sweet potato (Ipomoea batatas L.).
Methods. Field research on the comprehensive assessment of new sweet potato varieties was carried out in 2021–2022 at the Institute of Vegetable and Melon of the NAAS (Kharkiv Region). Phenological observations and biometric measurements of plants were carried out, as well as recording of meteorological data during the growing season, in particular during interphase periods of the culture. The stability of the studied traits was determined by finding the limit values of their manifestation (Xmax and Xmin) and further calculating the Levis phenotypic stability factor (SF).
Results. The use of the Levis phenotypic stability factor (SF) made it possible to determine the stability of the manifestation of morphological features of sweet potato varieties (I. batatas), in particular, the quantitative characteristics of tubers: their number under the bush for the variety ‘Admiral’ is 5.3 pcs., for ‘Slobozhanskyi rubin’ – 3.7 pcs.; the average weight of the tuber is 254 and 283 g, respectively. The trait “sweet potato tuber shape index” ensured stability with a coefficient of 0.98 (‘Admiral’) and 1.03 (‘Slobozhanskyi rubin’). The stability of the manifestation of morphological features of sweet potato tubers was established for the varieties ‘Admiral’ and ‘Slobozhanskyi rubin’, which are common in Ukraine. They represent two maturity groups, and therefore differ in the duration of the tuber formation period. Thus, the early-ripening ‘Admiral’ has a vegetation period of 100–110 days; medium-ripening ‘Slobozhanskyi rubin’ – 110–120 days.
Conclusions. The quantitative trait of sweet potato tubers of the ‘Admiral’ variety was more stable in terms of width; ‘Slobozhanskyi rubin’ variety – in terms length. Tuber length values varied within cultivars. The shape index of sweet potato tubers as an identification feature of varieties turned out to be variably unstable; the calculated Lewis phenotypic stability factor was lower than unity for both studied varieties.
The growing factors impact the productivity of new soft winter wheat varieties
Authors: Prysiazhniuk Larysa , Khomenko Tetiana , Liashenko Svitlana , Melnyk Serhii
Published: March 2023

Purpose. To determine the growing factors impact the economically valuable characteristics of new soft winter wheat varieties.
Methods. Field, biochemical methods, ANOVA.
Results. The influence of the growing zone, the growing season conditions and the genotype of the soft winter wheat varieties on yield, protein and gluten content were determined. The conditions of the growing zone have the greatest influence on studied varieties yield – 73%. On average, for 2020–2021, the maximum yield was obtained in the Forest-Steppe zone – 6.23–8.39 t/ha. In the Forest zone, the yield of studied soft winter wheat varieties was 5.31–7.02 t/ha. For the Steppe zone, the yield was within 5.16–6.63 t/ha. It was determined that varieties which showed low yield in the Forrest zone were characterized by higher yield in the Steppe zone. It was found that the growing zone (49%) and growing season (42%) conditions have the greatest effect on the protein content in grain of studied varieties. It was determined that variety ‘MANDARIN’ was characterized by the highest protein content in all growing zones (14.5–16.4%). In the Steppe and Forest-Steppe zones, high protein content was identified in grain of wheat varieties ‘Tata Mata’ (13.6–14.3%), ‘Eneida’ (13.6–14.3%) and ‘Novator’ (14.2 and 13.2%), in the Forest zone – in grain of varieties ‘Vahoma’ and ‘Eneida’ – 13.4% each. It was found that the growing zone conditions impacted gluten content in grain of studied wheat varieties by 64%, the influence of the growing season conditions was 28%. The effect of variety genotype on protein and gluten content was 5 and 4%, respectively. The grain of soft winter wheat varieties ‘MANDARIN’ and ‘Eneida’ contained the largest amount of gluten in all growing zones (27.7–31.8% and 27.3–30.3%). For the Steppe and Forest-Steppe zones, a high gluten content was found in grains of varieties ‘Illusion’ (28.4 and 30.8%) and ‘Tata Mata’ (27.8 and 29.8%).
Conclusions. It was found that growing zone conditions of soft winter wheat varieties (73%) and the interaction of factors zone × year (21%) impacted the yield significantly. The growing zone conditions (49 and 64%), growing season conditions (21 and 28%) and genotype of variety (5 and 4%, respectively) had a significant influence on protein and gluten content. Therefore, a significant influence of growing zone conditions on the productivity indicators of soft winter wheat determines the need to select varieties in order to obtain a high yield, taking into account the soil and climatic zone
Strategic planning of human resources as an entrance to enhance marketing capabilities: A case study of King Abdullah II Center for Design and Development (KADDB)
Authors: Mansour Abu-Jalil Mohammad , Okour Mohammad , Essbaih Mousa
Published: March 2023

The study aims to identify the impact of strategic planning of human resources in enhancing marketing capabilities at the King Abdullah II Center for Design and Development (KADDB). The descriptive and analytical methods were used to understand the effect of human resource planning in enhancing marketing capabilities. The research population includes all departments in the respective center. As for the sample, it consisted of 65 marketing and sales managers and workers in the marketing departments. A self-administered questionnaire was used to collect the research data. The results showed a significant effect of strategic planning for human resources in enhancing marketing capabilities at KADDB (R2 = 0.619, sig < 0.05). It was also found that strategic planning for human resources contributes to increasing the leader ability to do their work diligently and proficiently and improving the ability to organize work, distribute duties to subordinates, and coordinate efforts. Therefore, this study recommends giving strategic planning to human resources the importance it deserves for its active role in enhancing marketing capabilities at KADDB.
Atopic dermatitis management with topical corticosteroids in children: own observations
Authors: Skorokhodkina O. V. , Zaynetdinova G. M. , Khakimova R. F.
Published: March 2023

Atopic dermatitis is the most common chronic inflammatory skin disease in children, that significantly affects quality of life. Clinical manifestations are genetically determined and caused by skin barrier dysfunction and development of immune reactions. Atopic dermatitis is characterized by early onset, recurrence, and presence of treatment resistant forms. It is important to prescribe treatment that controls the symptoms and reduces the risk of severe forms of this disease. Topical corticosteroids are the mainstay of atopic dermatitis management, although the prolonged treatment can lead to development of side effects. The treatment option, that has high efficacy and high profile of safety, is the basis for disease remission and overcoming corticosteroid phobia. Methylprednisolone aceponate meets all criteria for topical corticosteroids and has high efficacy and high profile of safety. It can be recommended for patients with atopic dermatitis from the age of 4 months. This paper shows up-to-date data on methylprednisolone aceponate, that confirm the optimized efficacy/safety profile and minimal local or systemic adverse effects. Recent studies demonstrated the efficacy of new Russian product – methylprednisolone aceponate (Komfoderm K).
The feasibility of the use of monoclonal antibodies to interleukin 23 in the therapy of severe psoriasis with the eluding effect of genetically engineered biological drugs
Authors: Zhukova O. V. , Artemyeva S. I. , Al-Hawatmi A.A.-H. M.
Published: March 2023

Psoriatic disease is a condition characterised by the development of a progressive chronic inflammatory process caused by various immunological pathways, among which the IL-23/Th17 axis plays a key role. Therefore, the efficacy of IL-23 p19 inhibitors is currently being actively studied. To date, quite a large number of therapeutic options among genetically engineered biological drugs (GEBDs) exist for the treatment of psoriasis, but in real clinical practice patients may lose efficacy or suffer from adverse events, resulting in the need to switch to other classes of GEBDs. Guselkumab is a fully human IgG1λ monoclonal antibody that binds selectively to the p19 subunit of interleukin 23 (IL-23) with high specificity and affinity. The implementation of the drug into clinical practice has improved the efficacy, safety and survival rate of genetically engineered biological therapy for psoriasis. Finding optimal approaches to the treatment of psoriatic disease by analysing data from clinical trials and actual practice is the real challenge for practicing clinicians. However, a current problem is the lack of sufficient information on the use of guselkumab in real clinical practice when it is initiated subsequent to administration of other classes of GEBDs – anti-TNF-α, anti-IL-17 and/or anti-IL-12/23. This article provides a review of the existing literature, as well as our own clinical observations of non-bionaive patients with successful therapy switching to the IL-23 inhibitor guselkumab. Understanding the basic aspects of GEBD therapy for psoriasis will help to achieve successful control of the disease and improve the quality of life of patients in general.