bluuebunny/crossref_metadata_2025 huggingface dataset:
RADUAN NASSAR, LEITOR DE ALMEIDA FARIA
Authors: Marchezan Luiz Gonzaga
Published: July 2023

Raduan Nassar é leitor de Almeida Faria, conforme revelação do autor português no prefácio da edição brasileira de A Paixão, pela CosacNaify, em 2014. A mesma tensão entre o sagrado e o profano que lemos em A Paixão, de Almeida Faria, também localizamos em Lavoura arcaica, de Raduan Nassar. As relações familiares, nas duas narrativas, exalam paixões, vontades. O ordenamento religioso no interior da constituição das duas famílias educadas com o arcaico corresponde, nas duas obras, à obediência que elas dedicam aos seus dois patriarcas; quer ao puro patriarca de Lavoura arcaica, quer ao devasso de A Paixão. O paradigma do patriarcado mantém o controle dos poderes primários nas duas famílias. Os pais postam-se como autoridades morais e controlam as atitudes das suas famílias. O desejo, a vontade, entre familiares reproduzem as ordens dos patriarcas; reordená-los seria estabelecer uma luta por emancipação entre oprimidos, movimento que transformou Lavoura arcaica numa novela trágica, como mostramos neste artigo
EDITORIAL
Authors: Cortina Arnaldo
Published: July 2023

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Red Seaweed-derived Compounds: A Desired Approach for Treating Cancer
Authors: Katiyar Shweta , Jin Xing-Hai , Yadav Dhananjay
Published: July 2023

Cancer is a collection of diseases in which aberrant cells grow uncontrolled and invade surrounding
tissues. Cancer can be classified as carcinoma, sarcoma, leukemia, or lymphoma. The deadliest cancers are
lung, breast, colorectal, pancreatic, and prostate. Chemotherapy, surgery, and radiotherapy are the usual cancer
treatments. However, drug resistance poses a significant barrier to cancer treatment. Macroalgae are wellknown
producers of bioactive compounds with antimicrobial, antioxidant, anti-inflammatory, and anti-cancer
properties. Red algae, in particular, are a prominent source of bioactive substances, such as polysaccharides,
phenolic compounds, lipids, sterols, alkaloids, and terpenoids. Therefore, molecules from marine resources
could be an appealing way to identify new cancer treatment alternatives. This study aimed to provide a brief
overview of what is currently known regarding the potential of red macroalgae in cancer treatment by discussing
the primary therapeutic targets of the disease and identifying compounds or extracts with bioactive characteristics
against them.
Discovery and Development of a Class of New Conversion (PDF) in Friedländer
Condensation of o-aminonitrile with Carbonyl Compounds
Authors: Duan Jianyu , Zhang Qi , Su Ziqi , Xu Juan , Yang Junjuan , Li Jiarong
Published: July 2023

Since the discovery of the new conversion, through intramolecular Pinner to Dimroth
rearrangement to form a new skeleton product of dihydroquinazolinone in the normal
reaction of Friendländer quinoline synthesis of o-aminonitriles and carbonyl compounds, systematic
studies have shown that this conversion is a fast and efficient method for the synthesis
of nitrogen-containing heterocyclic compounds, especially pyrimidinone derivatives. In 2008,
we named this new transformation as a PDF conversion (a new conversion of dihydroquinolinone
skeleton compounds formed from intramolecular Pinner to Dimroth rearrangement in
the Friedländer quinoline synthesis). In this review, the research progress of PDF conversion
is systematically summarized from the following aspects: the discovery of PDF conversion,
the determination of the structure of new conversion products, the mechanism of PDF conversion,
a new type of organic bifurcation reaction, controllable PDF conversion, the breakthrough of conventional
PDF transformation forms, and the application of PDF conversion.
Covalent Modification of Proteins by Osthole Reactive Metabolites using Proteomic
Approaches
Authors: Zhuo Yue , Chen Huiling , Liu Chenchen , Zhang Yida , Fang Jiansong , Li Meng , Wang Zhendong , Jiang Qiyao , Yu Liangwen , Pan Huafeng , Wang Qi
Published: July 2023

Background:

Osthole (OST) is a bioactive natural coumarin derived from the plant Cnidium monnieri (L.)
Cusson fruit (She Chuang Zi), which has various pharmacological and biological activities. OST contains an α,β-
unsaturated lactone, which is an electrophilic group that tends to be metabolized into reactive metabolites (RMs).
Then, RMs are able to covalently modify nucleophilic amino acid (AA) residues of target proteins. However, few
researchers considered the contribution of the covalent modification induced by OST or its metabolites.

Objective:

This study aims to investigate the metabolic profile and the metabolites-protein modification of OST.

Methods:

The metabolites of OST were qualitatively identified using UHPLC-Q-TOF-MS. The RMs modification
patterns and potentially modified AA residues were confirmed by UHPLC-Q-TOF-MS using rat liver microsomes
(RLMs) and model AAs. Finally, the modified peptides derived from high-abundance microsomal peptides were
separated via nano-LC-Orbitrap-MS, and then RM-modified proteins were identified using a proteome discoverer.

Results:

In the presence of RLMs, OST could rapidly be metabolized within 1 h and hardly identified at 4 h. We
detected 10 OST metabolites, 13 OST metabolites-NAC (N-acetyl cysteine) adducts, 3 NAL (N-acetyl lysine) adducts,
and 11 GSH (glutathione) adducts. Furthermore, 16 RM-modified protein targets were identified, many of
which are included in the essential biological processes of OST’s anti-Alzheimer’s disease (AD) and anti-tumor.

Conclusion:

This study provides a novel perspective on the molecular mechanism of OST's pharmacological activities,
as well as identifies potential targets for further development and application of OST and other Natural products (NPs).
Monoclonal Antibodies and Antibody-drug Conjugates as Emerging Therapeutics for Breast Cancer Treatment
Authors: Saini Swati , Gulati Nisha , Awasthi Rajendra , Arora Vimal , Singh Sachin Kumar , Kumar Shobhit , Gupta Gaurav , Dua Kamal , Pahwa Rakesh , Dureja Harish
Published: July 2023

When breast cells divide and multiply out of control, it is called breast cancer. Symptoms include lump formation in the breast, a change in the texture or color of the breast, or a discharge from the nipple. Local or systemic therapy is frequently used to treat breast cancer. Surgical and radiation procedures limited to the affected area are examples of local management. There has been significant worldwide progress in the development of monoclonal antibodies (mAbs) since 1986, when the first therapeutic mAb, Orthoclone OKT3, became commercially available. mAbs can resist the expansion of cancer cells by inducing the destruction of cellular membranes, blocking immune system inhibitors, and preventing the formation of new blood vessels. mAbs can also target growth factor receptors. Understanding the molecular pathways involved in tumor growth and its microenvironment is crucial for developing effective targeted cancer therapeutics. Due to their unique properties, mAbs have a wide range of clinical applications. Antibody-drug conjugates (ADCs) are drugs that improve the therapeutic index by combining an antigen-specific antibody with a payload. This review focuses on the therapeutic applications, mechanistic insights, characteristics, safety aspects, and adverse events of mAbs like trastuzumab, bevacizumab, pertuzumab, ertumaxomab, and atezolizumab in breast cancer treatment. The creation of novel technologies utilizing modified antibodies, such as fragments, conjugates, and multi-specific antibodies, must be a central focus of future studies. This review will help scientists working on developing mAbs to treat cancers more effectively.
Aortic Intima-Media Thickness is Increased in Neonates of Mothers with
Gestational Diabetes Mellitus: The Role of Thioredoxin-Interacting
Protein as a Marker of Oxidative Stress
Authors: Triantafyllidou Pinelopi , Papadopoulou Anna , Thymara Eirini , Papaevangelou Vassiliki , Mastorakos George , Papadimitriou Anastasios , Kalantaridou Sophia , Stratakis Constantine A. , Alexopoulou Efthymia
Published: July 2023

Background:

Offspring exposed in foetal life to gestational diabetes mellitus (GDM) are at
increased risk for future metabolic diseases.

Objective:

To explore the prognostic role of abdominal aorta intima-media thickness (aIMT) in neonates
exposed to GDM as a possible biomarker for later atherogenesis and its possible correlation with thioredoxin-
interacting protein (TXNIP), a protein involved in oxidative stress.

Methods:

In this prospective, observational study, mother-infant pairs were studied in 2 groups (57
patients with GDM and 51 controls without GDM). TXNIP levels were measured in the placenta, as
well as in the umbilical and neonatal blood. The data were correlated with aIMT in neonates.

Results:

aIMT was increased in GDM offspring (patients: median [range]=0.39 mm [0.31-0.46] vs controls:
median=0.28 mm [0.23-0.33]; p=0.001) and remained significant after adjusting for possible confounders
(e.g., triglycerides, blood pressure, vitamin D, birth weight and gender; β coefficient=0.131
p=0.049). TXNIP levels were increased in trophoblasts (p=0.001) and syncytiotrophoblasts (p=0.001)
and were decreased in endothelial cells (p=0.022) in GDM offspring vs controls. Moreover, TXNIP
levels in trophoblasts positively correlated with aIMT (r=0.369; p=0.001). TXNIP levels in umbilical/
neonatal blood were not associated with GDM.

Conclusion:

Increased aIMT was demonstrated in the offspring of mothers with GDM. Non-invasive
measurement of aIMT could be used as a biomarker to identify children at increased risk for atherogenesis
later in life. This information may encourage early preventive measures. TXNIP may be associated
with GDM and/or aIMT.
A Review on Malnutrition in Children: Management and Treatment
Authors: Majumdar Ashish , Shukla Shiv Shankar , Pandey Ravindra Kumar
Published: July 2023

Malnutrition in children is a major problem in developing countries. An increased
number of children are dying because of a lack of nutrition in their regular diet. The nutritional
value of food during the growing stage of children is important. The development of the human
body requires various types of nutrition for normal growth, which is obtained from a regular
healthy diet. In this study, an exhaustive literature survey was done using Pubmed, Google Scholar,
and various other internet sources, and also other reference records were studied. This review
highlighted the causes and consequences of the perpetual lack of a healthy diet that leads to malnutrition.
It also summarized the steps taken for the management and treatment of malnutrition.
This review may be a vital tool for the researchers working on malnutrition for its proper understanding.
Adverse Effects of Gefitinib on Skin and Colon in a Lung Cancer Mouse
Model
Authors: Wang Yalei , Cheng Shuo , Zhang Huawei , Zhang Yali , Ding Chengcheng , Peng Tiantian , Chen Weihang , Yang Ke , Zhang Jiani , Tan Yan , Wang Xu , Liu Zhaoheng , Wei Peng , Jiang Miao , Hua Qian
Published: July 2023

Background:

Gefitinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
(EGFR-TKI), frequently causes side effects when used to treat non-small cell lung cancer

Objective:

The purpose of this experiment was to investigate the side effect of gefitinib on the skin
and colon of mice.

Methods:

Male Balb/c nu-nu nude mice aged 4-5 weeks were used as xenograft tumor models,
and gefitinib at 150 mg/kg and 225 mg/kg was started at 9 days after the xenograft tumor grew
out. The mice's weights and tumor volumes were tracked concurrently, and the mouse skin adverse
reactions and diarrhea were observed during the treatment. The animal tissues were subjected
to biochemical and pathological evaluations after 14 days.

Results:

Gefitinib effectively decreased the size and weight of transplanted tumors in nude mice,
while also lowering body weight and raising indexes of the liver and spleen. Gefitinib could cause
skin adverse reactions and diarrhea in mice. Further pathological investigation revealed tight junction-
related markers in the mice's skin and colon to be reduced and macrophages and neutrophils
to be increased after gefitinib treatment

Conclusion:

The findings imply that gefitinib has negative effects on the skin and colon. Gefitinib-
induced skin and colon adverse reactions in mice have been successfully modeled in this
study.
Screen Printed Electrodes: A Boon for Forensic Chemistry Analysis for
Detection of Narcotics and Explosives
Authors: Patil Ketan , Pandey Astha , Krishna Rohith
Published: July 2023

Screen printing technology is a method of ink-based printing that utilizes a stencil mesh screen to create a visual pattern on a flat surface, such as plastic or silk. This process finds application in the production of screen-printed electrodes, which are utilized in electrochemical cells as part of voltammetric techniques. These electrodes offer advantages in terms of simplicity, portability, and ease of use compared to more intricate techniques. Various voltammetric methods are employed to analyze materials present in trace quantities, including drugs and explosives. By employing screen-printed electrodes in these electro-analytical techniques, it becomes possible to achieve straightforward, cost-effective, sensitive, and rapid detection of analytes with forensic significance. This highlights the significance of screen-printed electrodes in both onsite and laboratory forensic examinations.
effect of service quality on customer loyalty
Authors: Octaviana Bella Claudia , Isnurhadi Isnurhadi , Shihab Muchsin Saggaff , Widiyanti Marlina
Published: July 2023

This study aims to determine the effect of service quality on customer loyalty. The independent variable in this study is service quality, and the dependent variable is customer loyalty. The method used in this study is quantitative because it uses data processing to produce numbers. This study uses a survey based on the research technique because it collects data by asking respondents directly through a questionnaire. The population in this study are customers at AXA Mandiri Palembang at Bank Mandiri Lemabang Palembang branch office, totaling 250 customers with active policy status starting from 2022-2023. The research sample is part of the population in this study, as many as 250 active policy customers from 2022-2023 at the Palembang Lemabang branch office. The research results are t count > from t table value of 6.231 with a significant value of 0.000 <? = 0.05. means that there is an influence between service quality and customer loyalty.
“The effect of the nozzle blade pitch on the velocity coefficient of the inflow turbine with partial blading of the runner
Authors: Kryukov A. A.
Published: July 2023

A numerical experiment with three groups of low-consumption inflow turbine with partial blading of the runner is considered in the paper. Geometric models of turbine stages with partial flapping of the runner with different grid spacing of the nozzle diaphragm have been developed. The object of this study is centripetal turbine stages with partial flapping of the impeller. The subject of the study is the efficiency coefficient and the velocity coefficient of the nozzles of the inflow turbine. The research method is numerical simulation of the working fluid flow using elements of computational gas dynamics. The aim of the study is to determine the effect of the nozzle blade pitch on the efficiency of the nozzle diaphragm of low-consumption inflow turbine with partial blading of the runner. The main objectives of the study are creating geometric models of turbine stages with different nozzle pitch, determining the boundary conditions of the experiment, conducting and processing the results of the experiment. The graphs of the dependence of the nozzle velocity coefficient and the efficiency of the low-consumption inflow turbine stage are provided. A comparative analysis of the nozzle velocity coefficient and the efficiency coefficient of three turbine stages with different grid spacing of the nozzle diaphragm is carried out. The velocity fields of the flow part of the turbine stages and the integral values of the parameters necessary for the three-dimensional calculation are obtained. The influence of the nozzle blade pitch on the velocity coefficient of the nozzle diaphragm and the efficiency coefficient of the turbine stage is determined. The nature and dependence of this geometric parameter on the efficiency of the study object is established, conclusions on further improvement of turbine stages with partial blading of the runner are made.
Conceptual scheme of intelligent vessel traffic control system with the human factor included
Authors: Fadyushin S. G.
Published: July 2023

The subject of the research is the development of technologies for automated and automatic ship traffic control systems, which is of great importance in modern shipping conditions. At the same time, special attention is paid to intelligent control systems based on artificial intelligence methods, such as artificial neural networks, fuzzy logic, machine learning, evolutionary computing and genetic algorithms. As a result, integrated information navigation systems, which provide decision-making on all aspects of navigation tasks, primarily where reception, processing, storage and transmission of navigation information is required, are being created and widely used in practice. However, in such developments, due importance is not given to the human factor, namely, it is often not taken into account that the control system of a moving object is a man-machine and consists of a regulator, which includes a human operator (navigator). The inclusion of the navigator in the vessel control link leads to the need to simultaneously take into account the human factor and the characteristics of the vessel controllability, i. e. human and machine factors in their unity. In connection with the development of artificial intelligence, the concept of “human-machine symbiosis” is becoming increasingly relevant in the study of human-machine systems. The problem is that there is still no single point of view on this issue due to the lack of reasonable methods for taking into account the human factor in the process of controlling the movement of moving objects. The results of the theoretical research on the formalization of some aspects of human mental activity and their implementation in the conceptual scheme of an intelligent vessel control system are reflected in the paper. The results obtained may be of interest to specialists in vessel traffic control automation, artificial intelligence, the creation of intelligent control systems and navigation safety.
The current state and possible prospects for using liquefied natural gas tank containers
Authors: Kuptsov N. V. , Lill’ A. V.
Published: July 2023

One of the ways to reduce emissions of harmful substances into the environment is considered in the paper. This way is connected with the transition from liquid and solid hydrocarbon fuels to liquefied natural gas, which is one of the reasons for the increase in gas fuel consumption with the observed growth in the last decade for its transportation in liquefied form in tank containers. The main countries owning tank containers are the USA, Germany and the UK. It is noted that tank containers are used for transportation and storage of liquefied gas in small volumes for end users; this method of transportation is mobile, since sea, rail and automobile transport can be used for this; storage of liquefied gas in tank containers does not require the construction of additional infrastructure. Further prospects of tank containers for liquefied natural gas are considered. The possibility of supplying gas by tank containers, especially for autonomous remote settlements and regions of the Russian Federation with a low population density, while in these regions the population needs gas for heating residential buildings, is discussed. The use of tank containers, due to its advantages, may have the potential for use in the Russian Federation. Thus, within the framework of the review study, the issues of the current state and prospects for the use of tank containers for LNG transportation are considered in detail. It is noted that the mobility and flexibility of transportation ensures storage without additional refrigeration systems for about three months, including that LNG tank containers are used for gas supply to sparsely populated and hard-to-reach points without connection to main gas pipelines, satisfaction of short-term peak gas consumption in winter, and use of gas as motor fuel for the various types of transport.
Analysis of regulatory documentation on seaports design in terms of technological processes automation at container terminals
Authors: Zub I. V. , Ezhov Yu. E. , Kasatkin G. D.
Published: July 2023

Seaports occupy one of the leading places in the foreign trade turnover of Russia. It is emphasized that the strategy of maritime activity of the Russian Federation provides for an increase in competitiveness through the modernization of existing and the construction of new terminals and seaports, which will give impetus to the development of ports and container terminals. The process of determining the port specialization and organizing its work, which is one of the initial stages for the planning process of the port construction or reconstruction, is investigated. The factors influencing not only economic and financial decisions, but also the introduction of information technologies that contribute to the automation of technological processes of the port, are also investigated. It is noted that new technologies have found application in ports where the production of loading and unloading operations is a repetitive process that can be modeled and programmed. It is indicated that most of the technological operations for the production of loading and unloading operations on modern lifting and transport equipment are automated, which increases the port efficiency, but not all ports can be automated, this is due to the possibility of accounting and control of the cargo unit, its location and shelf life, as well as identification. At terminals specializing in the bulk cargo transshipment, there are no such tasks for the management of lifting and transport equipment as at container terminals and terminals for the transshipment of bulk cargo and liquefied natural gas, which are initially automated. Automation is incorporated into the project during the construction of a new or reconstruction of an existing port or container terminal. The main documents that guide designers in the development of the project have been analyzed. Among them are “Set of rules 316.1325800.2017. Container terminals. Regulations of projecting”, “Set of rules 350.1326000.2018. Norms for technological design of sea ports” and “Set of rules 262.1325800.2016. Container yard and terminal devices in industrial and transport manufacture. Terms of design and construction”. They are obsolete and do not reflect modern requirements for technological processes. Special attention is paid to the fact that modern documents meeting the latest technological and technical requirements are necessary for the design of modern ports and terminals.
Identification of paramagnetic centers of gadolinium and iron in scandium and yttrium orthosilicates
Authors: Vazhenin V. A.  , Potapov  A. P.  , Subbotin K. A.  , Fokin A. V.  , Artyomov M. Yu.  , Titov A. I.  , Pavlov S. K.
Published: July 2023

The study of grown Sc2SiO5 : Gd and Sc2SiO5 : Fe crystals was carried out by the paramagnetic resonance method. It has been established that Fe3+ ions replace Sc3+ in both crystallographic positions, while Gd3+ ions exhibit a single center localized in a larger position with a coordination number of 7. Measurement of the orientational behavior of the positions of transitions of Fe3+ and Gd3+ centers in two orthogonal planes made it possible to determine the parameters of their triclinic spin Hamiltonians. To determine the localization of impurity ions Cr3+, Fe3+ and Gd3+ in scandium and yttrium silicates, the orientation of the main Z axes of the fine structure tensors of the second rank was used. Keywords: scandium and yttrium silicates, impurity ions, paramagnetic resonance.
Magnetic susceptibility of one-dimensional spin chains S(Ni-=SUP=-2+-=/SUP=-)=1 single crystal Y-=SUB=-2-=/SUB=-BaNiO-=SUB=-5-=/SUB=- in the region of 1.85-800 K
Authors: Petinov V. I.  , Kulakov A. B.
Published: July 2023

The magnetic susceptibility of chi(T) one-dimensional spin chains (OSCs) of a single crystal Y2BaNi05 was first studied in the range of 1.85-800 K. In the region from 800 to ~520 the OCC exhibits Curie-Weiss paramagnetism, in which chi0(T)=C/(T+800), where C is the Curie constant, with an effective magnetic moment of μeff=3.75 μB. With a decrease from 520 to 40 K, the susceptibility changes as a Halden magnet with a gap Delta=117 K, chi(T)=chi0(T)exp(-117/T). Below 40 K chi(T) grows again according to the Curie-Weiss law with μeff=3.75μB, thetai1=-3 K and ni1=9.3·1019 spins S(Ni2+)=1 per mole in a crystal grown in an oxygen-free environment; and thetai2=-1.3 K, and ni2=4.6·1019 spins S(Ni2+)=1 after annealing this crystal to 1000oC in air and its subsequent slow cooling.Such a change in the "impurity" contribution to chi(T) of the OCC is presumably due to a lack of O2 in a significant proportion of the terminal spins in the OCC of a single crystal Keywords: energy gap, SQUID measurements in the region of 1.85-800 K, end spins, breaks in the spin chain.
Synthesis and magnetic properties of zinc-tellurite glasses activated by magnetite nanoparticles
Authors: Shestakov M. V.  , Makoed I. I.  , Moshchalkov V. V.
Published: July 2023

An effect of activation with nanosized particles Fe3O4 on structural and magnetic properties of zinc-tellurite glasses 20·ZnO-(80-x)·TeO2-x·Fe3O4 (x=0, 1, 3, 7), prepared with melt-quenching method, have been investigated. Some functional properties of the glasses were experimentally investigated with X-ray diffraction, Energy dispersive and Raman spectroscopies, and SQUID magnetometry. The values of the average crystallite sizes calculated with Scherer and Williamson-Hall methods were comparable with the sizes of magnetically active clusters reconstructed from the results of processing of the magnetic field dependences of the values of specific magnetizations, indicating their effect on the change in the magnetic properties of activated glasses. A partial phase transformation, caused by oxidation of Fe2+ into Fe3+ ions, of ferrimagnetic magnetite Fe3O4 into paramagnetic maghemite γ-Fe2O3 has been revealed. Keywords: glass, glass-ceramics, nanoparticle, magnetite, magnetism.
Calcium supplementation on lowering blood pressure in pregnant women with hypertension: A meta-analysis
Authors: Radjulaeni Zakiah , Suhartono Suhartono , Mardiyono Mardiyono
Published: July 2023

Background: Hypertension in pregnancy causes 10% of pregnancy disorders worldwide which results in maternal morbidity and mortality of 9-26% and the incidence of premature births as much as 15% worldwide. From the results of previous meta-analysis, there is a relationship between calcium intake and the incidence of preeclampsia by consuming 1500-2000mg calcium during pregnancy, it is necessary to add calcium supplements to pregnant women because not all calcium intake in pregnant women from food is sufficient to meet calcium needs.

Objectives: Analyzing research studies on the effect of calcium on systolic blood pressure in pregnant women with hypertension in pregnancy, Analyzing research studies on the effect of calcium on diastolic blood pressure in pregnant women with hypertension in pregnancy.

Methods: Meta analysis by searching 24 research studies from 5 databases (Pubmed, Science Direct, Google Schoolar, Elsevier, and Proquest) using Randomized Control Trial (RCT), Experimental, and Cohort, published in 2013-2020.

Results: the results of the analysis of 5 studies involving 945 selected pregnant women with an average use of moderate doses (500 mg / day during the study) were divided into 2 groups. Providing calcium intervention since 20 weeks of gestation showed that calcium supplementation had a decreasing impact on maternal blood pressure in pregnancy. Analysis showed a difference in blood pressure in mothers with hypertension in pregnancy compared to mothers who did not consume calcium.

Conclusions: The use of calcium supplements during pregnancy can reduce blood pressure and prevent preeclampsia. The recommended dose is 500 mg/day from 20 weeks of gestation with mothers at risk of preeclampsia. Health workers need to ensure that pregnant women comply with the calcium consumption rules given so that the management recommendations can be carried out properly
Stunting prevention with determining BMI, UAC, haemoglobin (Hb) levels as early detection in adolescent students Muhammadiyah Senior High School Ponorogo West Java
Authors: Wijayanti Aida Ratna , Susilo Hayun Manudyaning , Ridlayanti Annisa
Published: July 2023

Background : One of the problems facing adolescent girls (23%) is iron deficiency (iron deficiency anemia) and it is higher than adolescent boys. Anemia in adolescent girls affect physical activity, learning concentration which will affect adolescent girls achievement.

Objectives: This study aims to determine Body Mass Image (BMI), Upper Arm Circumference (UAC), and Haemoglobin (Hb) Levels Pre Integration of Fero Sulfate (Fe) Tablets Supplements and to know relationship between BMI and UAC with Hb levels for Stunting prevention in students at Muhammadiyah Ponorogo High School.

Methods: The research design carried out was experimental research with an exploratory study approach, pre-experimental study design, the research takes on January to April 2023 in Muhamamdiyah High School Ponorogo. The samples was 54 people. Researchers analyze Hb, BMI, and UAC levels from all study samples and correlate all variables.

Results: The results show that BMI 48% (26 people) undernutrition, UAC 65% (35 people) underweight condition and Hb levels showed 87% (47 people) normal. The statistical analysis test shows that p-value test = 0.089 which means that there is no relationship between BMI and Hb levels in adolescent girls. Similarly, Hb levels with UAC show no relationship with p value 0.707.

Conclusions: The conclusion of this study, there are still many adolescent girls who experience malnutrition status, although found a few of these samples are anemic. So it is important that future studies on balanced nutritional intake and standardized Fe supplementation for stunting prevention in adolescence are important.
Ethical and Information Governance Considerations for Promoting Digital Social Interventions in Primary Care
Authors: Karampatakis Georgios Dimitrios , Wood Helen E , Griffiths Chris J , Lea Nathan C , Ashcroft Richard E , Day Bill , Walker Neil , Coulson Neil S , De Simoni Anna
Published: July 2023

Promoting online peer support beyond the informal sector to statutory health services requires ethical considerations and evidence-based knowledge about its impact on patients, health care professionals, and the wider health care system. Evidence on the effectiveness of digital interventions in primary care is sparse, and definitive guidance is lacking on the ethical concerns arising from the use of social media as a means for health-related interventions and research. Existing literature examining ethical issues with digital interventions in health care mainly focuses on apps, electronic health records, wearables, and telephone or video consultations, without necessarily covering digital social interventions, and does not always account for primary care settings specifically. Here we address the ethical and information governance aspects of undertaking research on the promotion of online peer support to patients by primary care clinicians, related to medical and public health ethics.
Testing a Culturally Tailored Advance Care Planning Intervention (MY WAY) for an American Indian Tribe: Protocol for a Quasi-Experimental Waitlist Control Design
Authors: Anderson Elizabeth , Goins R Turner , Haozous Emily A , Schweinhart April
Published: July 2023

Background

American Indian and Alaska Native peoples experience poor end-of-life care, including more hospitalizations and lower use of hospice and do-not-resuscitate orders. Although advance care planning (ACP) can improve end-of-life care, ACP rates are disproportionately low in American Indians and Alaska Natives.

Objective

We culturally tailored and delivered an existing evidence-based ACP program for an American Indian tribal community. Here, we present the protocol for assessing the intervention’s feasibility and efficacy.

Methods

We measured feasibility via participant recruitment, participants’ evaluation (acceptability, appropriateness, comprehension, and satisfaction), and intervention fidelity. Recruitment was measured with participant screening, eligibility, enrollment, and retention. Participant’s evaluation of the intervention was measured with surveys. Fidelity was measured with direct observation and the Make Your Wishes About You (MY WAY) Fidelity Checklist Tool. To assess the intervention’s efficacy, we used a quasi-experimental waitlist control design with 2 cohorts who were surveyed each on three separate occasions. The intervention’s efficacy was assessed by the following: ACP barriers and facilitators as well as ACP self-efficacy, readiness, and completion.

Results

A total of 166 participants were screened for eligibility; 11 were deemed ineligible, and 155 participants were enrolled in the study. Of those enrolled, 113 completed the intervention and will be included in subsequent analyses. We finalized data collection in January 2023, and analyses are underway. Study enrollment was successful, and we expect that participants will report high levels of acceptability, appropriateness, comprehension, and satisfaction with the intervention. We expect that the intervention was implemented with fidelity and will demonstrate decreases in ACP barriers and increases in ACP facilitators, self-efficacy, readiness, and completion.

Conclusions

Enrolling over twice as many participants as we had hoped suggests that members of this tribal community are willing to engage in end-of-life ACP. We were able to implement a waitlist study design to show that a culturally tailored ACP program for a tribal community is feasible.

Trial Registration

ClinicalTrials.gov NCT05304117; https://clinicaltrials.gov/study/NCT05304117

International Registered Report Identifier (IRRID)

DERR1-10.2196/50654
AI in Psoriatic Disease: Scoping Review (Preprint)
Authors: Barlow Richard , Bewley Anthony , Gkini Maria Angeliki
Published: July 2023

BACKGROUND

Artificial intelligence (AI) has many applications in numerous medical fields, including dermatology. Although the majority of AI studies in dermatology focus on skin cancer, there is growing interest in the applicability of AI models in inflammatory diseases, such as psoriasis. Psoriatic disease is a chronic, inflammatory, immune-mediated systemic condition with multiple comorbidities and a significant impact on patients’ quality of life. Advanced treatments, including biologics and small molecules, have transformed the management of psoriatic disease. Nevertheless, there are still considerable unmet needs. Globally, delays in the diagnosis of the disease and its severity are common due to poor access to health care systems. Moreover, despite the abundance of treatments, we are unable to predict which is the right medication for the right patient, especially in resource-limited settings. AI could be an additional tool to address those needs. In this way, we can improve rates of diagnosis, accurately assess severity, and predict outcomes of treatment.

OBJECTIVE

This study aims to provide an up-to-date literature review on the use of AI in psoriatic disease, including diagnostics and clinical management as well as addressing the limitations in applicability.

METHODS

We searched the databases MEDLINE, PubMed, and Embase using the keywords “AI AND psoriasis OR psoriatic arthritis OR psoriatic disease,” “machine learning AND psoriasis OR psoriatic arthritis OR psoriatic disease,” and “prognostic model AND psoriasis OR psoriatic arthritis OR psoriatic disease” until June 1, 2023. Reference lists of relevant papers were also cross-examined for other papers not detected in the initial search.

RESULTS

Our literature search yielded 38 relevant papers. AI has been identified as a key component in digital health technologies. Within this field, there is the potential to apply specific techniques such as machine learning and deep learning to address several aspects of managing psoriatic disease. This includes diagnosis, particularly useful for remote teledermatology via photographs taken by patients as well as monitoring and estimating severity. Similarly, AI can be used to synthesize the vast data sets already in place through patient registries which can help identify appropriate biologic treatments for future cohorts and those individuals most likely to develop complications.

CONCLUSIONS

There are multiple advantageous uses for AI and digital health technologies in psoriatic disease. With wider implementation of AI, we need to be mindful of potential limitations, such as validation and standardization or generalizability of results in specific populations, such as patients with darker skin phototypes.
A Meta-analysis of Studies on the Therapeutic Effects of Digital Therapies (Preprint)
Authors: Seo Young Chul , Yong Sang Yeol , Kim Sung Hoon
Published: July 2023

BACKGROUND

Digital therapies are being studied as a new treatment method that can have higher efficacy than traditional treatments such as pills or biological agents.

OBJECTIVE

The aim of this study was to meta-analyze the results of digital therapy studies conducted from January 2017 to October 2022 to understand the overall treatment outcomes.

METHODS

Seven studies and eight control groups were analyzed using Hedges’ g to calculate effect sizes.

RESULTS

The weighted average effect size for the eight control groups was 0.91 (Hedges’ g = 0.91, 95% CI: 0.62 to 1.20), indicating a moderate to large effect size. Furthermore, excluding one study, the weighted average effect size was 1.13 (Hedges’ g = 1.13, 95% CI: 0.91 to 1.36), indicating an even larger effect size. The quality of the studies was assessed using the Bias Risk Assessment Tool developed by the Cochrane Group, and the risk of bias was found to be low.

CONCLUSIONS

This study confirmed that digital therapies can have important treatment effects. Digital therapies offer advantages such as easy management of patients’ treatment processes and personalized treatment. However, digital therapy may have limited efficacy for patients who lack the ability to use digital devices or software. Therefore, it is necessary to clearly understand the relevant advantages and disadvantages and search for more effective treatment methods in conjunction with the active use of digital therapies.
ICT Training to Improve CLC Data Management through Nonformal Education Service Program
Authors: Tohani Entoh , Fauziah Pujiyanti , Prasetya Iis , Munifah Munifah , Sylviani Dewi
Published: July 2023

The COVID-19 pandemic has shifted the habit of face-to-face offline learning to online learning using Information, Communication and Technology (ICT). This happens in all education units, including the Community Learning Centre (CLC). Community learning centre, as nonformal education unit, has flexible characteristics. Nevertheless, it still has the competitiveness to provide learning according to the needs of students during the COVID-19 pandemic. Community activities are voluntary-based, where technology uses are still partial and not optimal. For this reason, community service activities through the training aim to provide knowledge about how information, communication, and technology are used in data management and learning. This community service program approach was carried out qualitatively by conducting in-depth interviews with community samples in each district of Yogyakarta. The offline activity was attended by 20 participants from CLC in Yogyakarta City. With this direct training and workshop, community managers can practice using cloud storage for data management and use online conference and presentation applications to support the creation of learning media.
Education of COVID-19 Vaccination for Pregnant Women
Authors: Juliana Monica , Hanifah Laily , Karima Ulya Qoulan
Published: July 2023

Various preventive, promotive, and curative efforts have been made by the government to prevent the increase in COVID-19 cases in the community. The successful endeavor to halt the transmission of COVID-19 undeniably requires the active participation and collaboration of diverse parties, one of which is Dasawisma cadres. The role of Dasawisma cadres who serves the community directly makes them vulnerable to COVID-19 so it is necessary to be COVID-19 vaccinated. This community service aims to increase the knowledge of Dasawisma cadres about COVID-19 vaccination for pregnant women. The education was carried out online through zoom meetings attended by 437 participants. Based on the analysis, it is known that the p value is 0.000 (<0.05), which means that the education provided was useful to improve the knowledge of cadres about vaccination for pregnant women. Hopefully, the education will be continued especially regarding the importance of boosters that promote by the government.
Research on Strengthening Teachers’ Ethics in Colleges and Universities in the New Era
Authors: Chen Yujiao
Published: July 2023

The new era of college education affects the level of national higher education, and college teachers as a group of teaching and educating people, is particularly important, teacher ethics and teacher style is the soul of the teaching profession. Strengthening the construction of teacher morality is a major issue related to the new era of education can establish moral character. At present, the overall construction of teacher morality and teacher style shows an upward and good state, but with the social reform and development, affected by a variety of factors, the thinking of some college teachers is also undergoing profound changes, there are still some problems in teacher morality and teacher style need to be corrected. The construction of teacher ethics in colleges and universities in the new era is very important.
Reading Dysfluency in Indian Classrooms: An Insight
Authors: Balasubramaniam Bhawani
Published: July 2023

Reading text in English is an important skill for students of higher education in India, as their understanding of their core subjects in specific and the world of information in general is based upon this skill. The ability to read English fluently, increases their job prospects also, as real time job environments use English as the official medium of communication and require that students read English with ease. Technical students who engage primarily with numerical data, diagrams and other non-textual content in their core subjects, have an especially hard time coping with tasks which involve reading textual English. There are several problems that lead to lack of fluency and thus lack of understanding of the content. This paper will study reading “ dysfluency “ problems technical students face, when reading English like word recognition difficulties, inability to read in sense groups, problems to do with accuracy, automaticity and expression. This paper will attempt to offer strategies to overcome this problem like Loud reading, Echo reading and Choral reading and some unconventional reading practices that can help solve this very common but important skill gap.
Desequilibrio postural y maloclusión clase III en un paciente con síndrome de hipoplasia femoral y facies inusual. Caso clínico
Authors: Aguirre-Bautista Carlos Roberto , Servín-Hernández Silvia Victoria
Published: July 2023

Introducción. El desequilibrio de las arcadas dentales (maloclusión) condiciona la dinámica mandibular, afectando el sistema estomatognático, además puede provocar posturas inadecuadas. La oclusión interviene de manera determinante en el complejo muscular de flexión de la cabeza y su relación con el tronco superior del cuerpo. Caso clínico. Paciente masculino de 5 años que acude a tratamiento ortopédico de los maxilares por presentar asimetría facial. La tomografía axial computarizada descartó malformación vascular derecha. El ultrasonido doppler de mejilla derecha encontró hiperplasia de tejido adiposo. En la exploración extraoral presenta una asimetría facial a expensas de hiperplasia de tejido adiposo del tercio medio inferior de hemicara derecha, mentón prognático, perfil y convexo, tono, posición y volumen labial aumentados. En la exploración intraoral se observó mordida cruzada anterior con sobremordida vertical negativa, incremento de crecimiento a nivel de la zona maxilar derecho, el rafe medio del maxilar se observó desviado al lado izquierdo, lo cual da la apariencia de mayor tamaño del lado derecho que el izquierdo, esta misma alteración de forma y tamaño se presenta en la arcada inferior. En la radiografia panorámica se observó asimetría en forma y tamaño del cuerpo y rama mandibular, forma alterada y tamaño del cóndilo mandibular del lado derecho, en lateral de cráneo prognatismo mandibular, en cefalometría frontal se observó asimetría postural muy aumentada, posibles problemas respiratorias y desviación del plano oclusal. En el análisis postural presenta genu valgo en rodillas y tobillos, pie plano del lado derecho, cresta iliaca asimétrica y escoliosis funcional. Conclusión. Los datos clínicos permiten sugerir el diagnóstico de síndrome de hipoplasia femoral y facies inusual, el cual debe ser tratado en forma multidisciplinaria, en el que el ortodoncista tiene una participación preponderante. Palabras clave: Maloclusión, postura, asimetría, síndrome
Calidad de tesis de grado en educación médica en Perú: Un estudio transversal
Authors: Cordero-Chunga Aldrín Gabriel , Flores-Cohaila Javier Alejandro
Published: July 2023

Introducción: La baja tasa de publicación de las tesis de grado de educación médica en Perú limita el avance y la innovación de esta área. Se ha reportado que la calidad de la investigación en educación médica se asocia con la publicación en revistas científicas. Es por ello esencial identificar y mejorar la calidad de estos productos académicos.

Objetivo: Describir la calidad de la tesis de pregrado enfocadas en educación médica de Perú usando el instrumento Medical Education Research Study Quality Instrument e identificar que otros factores influyen en la calidad.

Método: Realizamos un estudio transversal analítico tomando como unidad de análisis a las tesis de grado enfocadas en educación médica ubicadas en el repositorio de Acceso Libre a la Información Científica para la Innovación de Perú. Evaluamos la calidad usando el MERSQI, otras variables recolectadas fueron: año de publicación, tipo de universidad, tesis publicada, experiencia del asesor y temática. Realizamos un análisis estadístico para identificar diferencias entre el MERSQI con respecto a la experiencia del asesor, si la tesis fue publicada y el tipo de universidad.

Resultados: Analizamos 20 tesis de grado enfocadas en educación médica. El MERSQI promedio fue de 9.13 ± 1.73. La mayoría de estudios fueron de diseño transversal y se enfocaron en estudiantes de medicina. El dominio peor calificado del MERSQI fue el de validez del instrumento. No encontramos diferencias significativas en el puntaje del MERSQI según tipo de universidad, tesis publicada y experiencia del asesor.

Conclusiones: Nuestros resultados identifican un MERSQI por debajo de la media internacional. Además, sugieren que existe una ausencia de asesores con experiencia en educación médica. Se requieren intervenciones para incrementar la calidad de la investigación en educación médica en Perú.