bluuebunny/crossref_metadata_2025 huggingface dataset:
Conditions of formation of professional competence in pedagogical practice of future history teachers
Authors:   Глухівський національний педагогічний університет імені Олександра Довженка, Hrytsenko A.
Published: June 2019

The author in the article analyzes the basic theoretical provisions of the conditions for the formation of professional competence among future teachers of history and presents the main approaches on this issue, which have developed in modern pedagogical and psychological literature. At the same time, attention was drawn to the differences between the two interrelated concepts of "competence" and "competence", as well as the three-component structure of the competence system in education, which includes key or basic, general-sectoral and vocational-specialized (subject) competencies acquired while studying one or another discipline and defining the term "professional competence". In the article, the main features of professional competence are highlighted: the need for knowledge formation, provided they are aware of their significance for future professional activities, a set of operational skills; the development of an algorithm for the implementation of professional exercises and the ability to creativity in the performance of professional tasks. This made it possible to determine the conditions for the formation of professional competence for future teachers in the course of their continuous and systematic activities if they have the appropriate professional qualities that contribute to this activity and general abilities based on knowledge, experience, values acquired through learning, upbringing, integration into the space of social and cultural relations. In addition, the psychological aspects of the formation of students of institutions of higher education of the indicated competence, which allows to significantly improve the effectiveness of the educational process during the training of future specialists, which accompanies the process of assimilation of theoretical foundations, means and methods of fulfilling professional tasks, can be considerably improved; ability to analyze, predict and independently choose means and means of action in certain specific situations; the ability to self-development and self-realization in the context of mastering modern scientific achievements and their implementation and positive attitude to their future professional activities. Key words: competence approach, history, competences, professional competence, future teachers, professional training, professional educational qualifications.
Pecularities of H. C. Andersen’s tales contextual studying at the lessons of child’s literature with future primary school specialists
Authors:   Миколаївський національний університет імені В. О. Сухомлинського, Kazanzhy O.
Published: June 2019

The article raises the problem of the artistic works context study at the children's literature classes in the process of training elementary school future specialists. It is relevant in the context of creating a new Ukrainian school which is based on a competent approach to the educational process. Contextual study of artistic works is sufficiently effective for understanding its issues and ideas. It is emphasized by V. Hladyshev and L. Miroshnichenko in their methodological studies. As it is noted in the study such an approach is often ignored in the analysis of literary tales. That is why we suggest examples of the contextual studying method use while getting acquainted with the creative works of Danish storyteller H. C. Andersen. Considering the biographical, moral, aesthetic and cultural contexts, the following works have been analyzed in the study, such as: "The Ugly Duckling", "The Snow Queen", "The Little Mermaid", "The Nightingale" and "The Snail and the Rosebush". Philosophic-Christian interpretation of fairy tales, which corresponded to the personal Christian outlook of their author, is emphasized. In particular, the concept of sacrificial Christian love and spiritual humility, which govern the actions of the protagonists of the storyteller’s works, contribute to their spiritual growth. From this very side one should approach the analysis of fairy tales "The Snow Queen", "The Little Mermaid", "The Nightingale" and "The Pen and the Ink". The tales "The Ugly Duckling" and "The Snail and the Rosebush", in addition to the writer's world-wide orientations, reveal the individual facts of his life. In order to understand the essay fully, you need to plunge into biographical information about the writer. An important source of information about the life and outlook of the storyteller is his autobiographical work “The Tale of My Life” in which the true Andersen appears to the reader. Consequently, the interpretation of H. C. Anderson’s tales with the use of works context study methodology opens their new understanding, which enables future educators to place important accents, identify the educational subtext and the main idea correctly and to approach the school analysis of these works taking into account the necessary details. Keywords: context, contextual study, biographical context, analysis, literary tales, subtext, world view.
Modern methods of “computer graphics” in the system of cybersecurity professionals’ preparation
Authors:   Національний авіаційний університет, Matviichuk-Yudina O.
Published: June 2019

The article describes the directions of using modern information technologies in the development of electronic educational resources (EER), includes the comparative analysis and also determines the content of the subject "computer graphics" for future bachelors in information technology (IT) and cybersecurity, is describing a model of competency formation for computer graphics considering the requirements of the international system of standards, as well as the proposed basic characteristics of competencies reflecting the educational requirements on mastering modern information technologies of design, infographics, steganography and holography. The foreign and domestic experience of professional training of future bachelors of cyber security is generalized. According to the standards of the Industrial Model of Cybersecurity, competencies in computer graphics of future bachelors of cybersecurity are specified: the ability to provide a process of concealing critical video information in information and communication systems (steganography); the ability to provide processes for holographic protection of information resources in information and communication systems (holography); the ability to design, provide and maintain various classes and types of infographic systems. An approach to the system of competency creation, which sets the boundary for professional and modern perception of the IT industry, is presented. Investigated the modern aspects of training of IT specialists in the conditions of an effective system of professionally oriented training and introduction of a quality management system, informatization of educational processes, determine the theoretical foundations of informational and analytical support of the educational process of preparing future bachelors in cybersecurity. These processes should be based on a single information space and integrated information resources of the educational institution. Keywords: Complex of electronic educational resources, future bachelors of cyber security, computer graphics, professional competencies, international system of standards ISO, standards of the Industrial model of cyber security.
The school of business as one of the factors of professional education’s multy-degree system
Authors:   Мукачівський кооперативний торговельно-економічний коледж, Stebljuk S.
Published: June 2019

The article reveals one of the forms of non-auditing activity of the educational institution of the economic direction and business school in particular. The author sets the goal of forming the economic competence of graduates of secondary schools at the business school classes in college conditions, which is one of the factors in ensuring multy-degree system of education. There were tasks: to find out the role of the business school in Ukraine and abroad, to uncover the organization and conducting of classes of such school based on an educational institution of economic direction. The research of this problem was conducted in two directions: theoretical and practical research. The theoretical study of the question gave an opportunity to find out the various forms of business schools. As an example, a business school providing additional information for entrepreneurs, a counseling form, as an extracurricular work. On the basis of the trade and economic institution of education, a business school was organized in order to attract students from secondary schools in Transcarpathian region to economic education, to study the basics of economic sciences, to acquire skills, to navigate themselves in the current market conditions, and to cause an interest in future entrepreneurial activity. The form of conducting the research was not lecture or practical lessons, but innovative ones. The training was made in the form of a game in accordance with the scientific principles, accessibility, communication with life, emotional training. The training session enabled the students to create groups, where participants had common interests, to get acquainted, and identify the leader. It was established (according to the results of the questionnaire of the participants) that the most productive were the quest lessons and business simulation classes. Our observation has shown that such classes develop the creativity of modern youth, the actual vision of business development and proved the effectiveness of such business schools. It was also stated that students had a motivational interest in future studying on economic faculties. Youth Business Projects Contest «Businessman in 5 Minutes», which was conducted in our college, showed the presence of entrepreneurial inclinations, as the proposed projects were aimed at their own vision of improving the business situation in Transcarpathian region, and this brought up the feeling of citizenship and patriotism. It was found out that multy-degree system of education within the framework of “school-college-university” is effective. The organization of business schools should help the future entrants to get acquainted with the world of professions, to become interested in domestic educational institutions. Key words: multy-degree system of education, extracurricular work, business school, innovative teaching methods.
Tasks with algorithms, OR-quests and acr-discussion in the context of preparation of future linings
Authors:   Бердянський державний педагогічний університет, Khalabuzar O.
Published: June 2019

The article focuses on the necessity of forming a culture of logical thinking of future teachers and logical knowledge in particular. Reforming the education system of Ukraine, which is connected with global integration into the global educational space, the introduction of a person-oriented, humanistic paradigm, the implementation of developmental vocational training, makes intensification of the requirements for the professional thinking of the future linguist, which should be characterized by such features as: autonomy, flexibility, reflexivity, creativity, systemicity, criticality, openness, etc. Adherence to favorable conditions that will help develop personal qualities will allow a specialist to successfully solve both life and professional tasks, create favorable conditions for the training of future students, their education, comprehensive harmonious development in accordance with the requirements of the present. The above transformational processes make it necessary to introduce in the process of professional training future linguists such essential technologies that will contribute to the formation of a culture of their professional thinking in general and the culture of logical thinking in particular, which envisages improvement of logical knowledge and intelligence of future specialists. Taking into account that mastering modern information technologies is one of the main components of specialist training, an online resource was developed and applied in the educational process, aimed at mastering the basics of the necessary knowledge about the culture of logical thinking. In order to remotely formulate logical thinking, students perform tasks that are posted on a blog site, make summaries of the material provided on the site. During the formation of logical knowledge and skills also should be used project methodology. Preparation of projects requires students of a significant level of formation of the culture of logical thinking, because the need is for the ability to analyze information, highlight the main thing, generalize, draw conclusions and predict the effectiveness of the projects being developed. The potential possibilities of non-standard tasks with logical load, focused on mastering of logical knowledge and skills of future specialists during professional-pedagogical training of specialists in higher educational establishments (on the basis of humanitarian disciplines) are revealed. Key words: formation of a culture of logical thinking, reforming the education system of Ukraine, methodical methods, non-standard tasks with logical loading.
The role of gamification exercises created with the help of the Hot Potatoes program in the formation of ship engineers’ communicative competence
Authors:   Морський коледж Херсоснької державної морської академії, Yurzhenko A.
Published: June 2019

Our research deals with the use of innovation technologies in the professional training of future marine specialists, namely ship engineers. As the title implies the article describes the role of gamification activities (educational exercises in the form of a game) created with the help of the Hot Potatoes program and placed in LMS MOODLE (Learning management system Modular Object-Oriented Dynamic Learning Environment). Couple of “gamification activities” definitions are listed. The advantages of gamification activities while studying English for specific purpose are mentioned (diversify of the routine implementation of typical exercises in the educational and communicative electronic environment, increasing of motivation, prolonged term of interest in solving the problem and increasing of the probability of achieving the studying goal). The types of Hot Potatoes program gamification activities (JClose, JMatch, JQuiz, JCross, JMix, The Masher) are described. Their application in electronic courses in LMS MOODLE to study Maritime English for professional purpose is described. The elements of gamification of every created with the help of Hot Potatoes program activity are listed (points and marks, the possibility of using hints and clues, visual progress, the right to mistake, the opportunity to start the game again, game design – the presence of special buttons). It is highlighted that JClose allows teachers to create gap-filled activities with gamification elements; JMatch creates activities to match elements of two groups; JQuiz uses four types of tasks (Short answer; Multiple choice; Mixed; Alternative choice) and creates quiz; JCross creates crosswords; JMix mixes types of activities; The Masher allows to create units from the packages of the above types of exercises program automatically. The article proves that Hot Potatoes program exercises diversify the routine implementation of typical exercises in electronic courses of LMS MOODLE, increase motivation of students to study and learn English for specific purpose, extend the term of interest etc. To make further research in this field we are going to study Qedoc, Xerte and iSpring programs and the role of created with their help gamification activities in formation of the communicative competence of future marine specialists, namely ship engineers. Key words: gamification activities, LMS MOODLE, Hot Potatoes, ship engineers, communicative competence.
The problem of determining the pedagogical biographistics’ subject field
Authors:   Мукачівський державний університет, Rozman I.
Published: June 2019

The article substantiates the need for the constitution of pedagogical biographistics as a separate branch (direction; subdiscipline) of historical and pedagogical science. Through the prism of scientific discourse it turns out its subject field, status, the main components and attributes of cognitive capabilities, other characteristics. It is shown that the object of pedagogical biographistics is the pedagogical personality in the diversity of its connections with the socio-cultural environment of a certain historical period, the unity of its individual and social, reflected in the life path and process and the results of social activity and creative development. The main structural components of this object are defined and characterized: a complex of external socio-political and socio-cultural factors; psychophysiological features and qualities of the person; her life path in all its completeness and uniqueness; spheres and directions of social activity; the role and meaning of a person in the history of education, pedagogical thought, the implementation of social projects. It has been argued that the subject of pedagogical biographistics outlines the scientific and theoretical foundations and the process of organizing the study of pedagogical personalities. Its definition should answer three basic questions: “Who should be researched?”; “How to research?”; “Where are the boundaries of biographical knowledge?”. The definition of pedagogical biographistics as a separate branch (subdiscipline) of historical and pedagogical science is proposed, which, based on a special conceptual categorical apparatus, scientific research toolkit and relevant source base and scientific and historiographical works, studies pedagogical personalities as integral phenomena with an emphasis on their life path, creative heritage, vocational education and public-educational activities, and clarifying the role and significance of pedagogical thought development. It is emphasized that the dominant in the study of the history of pedagogy is the historical and cultural process in its comprehensive study: the correlation of different levels of pedagogical phenomena with the present in the context of social conditions of their existence and patterns of human development, the interconnection of humanitarian disciplines for a deeper understanding of the person. Key words: pedagogical biographistics, pedagogical personality, historical and pedagogical science, branch of pedagogical science, scientific methodology, scientific research toolkit.
Política educacional para a educação de jovens e adultos no governo Lula: construção da agenda, formulação da política e implantação
Authors: Alves Luísa Helena Silva e , Ribeiro Elisa Antônia
Published: June 2019

Este artigo objetiva analisar a política educacional do Programa Nacional de Integração Profissional na Modalidade de Educação de Jovens e Adultos – PROEJA, instituído pelos Decretos nº 5.478 de 24 de julho de 2005 e n° 5.840 de 13 de julho de 2006. Neste estudo, são apresentados a trajetória da Educação de Jovens e Adultos no Brasil, uma contextualização da arena política do Governo Lula, as concepções e princípios estabelecidos no PROEJA, o Documento Base e as ações advindas das etapas de construção da agenda, da formulação da política e da implantação do PROEJA. O estudo foi realizado em fontes documentais e bibliográficas, permitindo estabelecer um panorama dos avanços do PROEJA nos últimos anos.
Processos educativos inerentes do “fazer o samba” por Bezerra da Silva (1927-2005) e a produção do conhecimento em espaços não escolares
Authors: Souza Tiago Zanquêta de , Melo Aldiôney Pereira de
Published: June 2019

Este artigo tem como objetivo identificar processos educativos inerentes ao “fazer o samba” por Bezerra da Silva (1927-2005). Está ancorado no referencial da Educação Popular, por meio da revisão de literatura. A expressão das vozes do samba sofreu preconceitos e um intenso processo de marginalização. Porém, a capacidade de resistência, fruto das privações materiais decorrentes da exclusão social forjou, no interior das comunidades cariocas, uma outra tessitura social. Assim, as comunidades encontraram no samba e nas demais manifestações artísticas, a instrumentalização metodológica necessária para a construção de saberes e denúncia das injustiças. Em outros termos, o samba de Bezerra da Silva cumpriu seu papel educativo, importante naquelas comunidades esquecidas pelo poder público e, muitas vezes, desconhecidas pela educação escolar.
Investigating the Effects of Multicollinearity on the Model Parameters of Ordinary Least Squares Estimator
Authors: Gatta Nusirat Funmilayo , Waheed Banjoko Alabi
Published: June 2019

This study investigated the effects of multicollinearity on the model parameters of the ordinary least squares regression model. The aim was to examine the impacts of multicollinearity on the efficiency of classical Ordinary least squares (OLS). Data were simulated from a multivariate normal distribution with mean zero and variance-covariance matrix at various sample sizes 25, 50, 100, 200, 500 and 1000. To assess the asymptotic efficiency and consistency of the regression models in the presence of multicollinearity, the evaluation criteria used were the Variance, Absolute bias, Mean Square Error (MSE) and Mean Square Error of Prediction (MSEP). Results from the analysis revealed that the OLS is not efficient given the large MSE, MSEP, and Absolute bias.
Mycoplasmas and Their Antibiotic Resistance: The Problems and Prospects in Controlling Infections
Authors: Chernova O. A. , Medvedeva E. S. , Mouzykantov A. A. , Baranova N. B. , Chernov V. M.
Published: June 2019

The present review discusses the problem of controlling mycoplasmas (class Mollicutes), the smallest of self-replicating prokaryotes, parasites of higher eukaryotes, and main contaminants of cell cultures and vaccines. Possible mechanisms for the rapid development of resistance to antimicrobial drugs in mycoplasmas have been analyzed. Omics technologies provide new opportunities for investigating the molecular basis of bacterial adaptation to stress factors and identifying resistomes, the total of all genes and their products contributing to antibiotic resistance in microbes. The data obtained using an integrated approach with post-genomics methods show that antibiotic resistance may be caused by more complex processes than has been believed heretofore. The development of antibiotic resistance in mycoplasmas is associated with essential changes in the genome, proteome, and secretome profiles, which involve many genes and proteins related to fundamental cellular processes and virulence.
Heat Stress-Induced DNA Damage
Authors: Kantidze O. L. , Velichko A. K. , Luzhin A. V. , Razin S. V.
Published: June 2019

Although the heat-stress response has been extensively studied for decades, very little is known about its effects on nucleic acids and nucleic acid-associated processes. This is due to the fact that the research has focused on the study of heat shock proteins and factors (HSPs and HSFs), their involvement in the regulation of transcription, protein homeostasis, etc. Recently, there has been some progress in the study of heat stress effects on DNA integrity. In this review, we summarize and discuss well-known and potential mechanisms of formation of various heat stress-induced DNA damage.
工学结合教学模式下的高职教学管理现状分析
Authors: 戴 青松
Published: June 2019

高职院校在对学生开展专业教学过程中，需要思考怎样让学生对专业知识进行能动性的探索，在掌握理论知识基础上又能实现专业技能的有效培养。所以高职院校必须要积极改变传统的教学模式，给学生打造更优质的知识探索平台，让学生实现专业技能的有效培养。工学结合是一项创新性的教学模式，在该种知识教育引导下，学生不仅可以对理论知识进行有效的学习，也能在教学实践中分析和运用自己所学的专业知识。所以，本文主要分析高职院校在工学结合该种教学模式指导下教学管理存在的问题，提出几点合理提升教学管理质量的措施，希望让高职院校可以开展更高层面工学结合的专业教育。
独立学院深化创新创业教育路径研究
Authors: 刘 雄
Published: June 2019

创新创业教育的根本目的在于培育兼具创业基本素养以及开创型个性的人才,是我国人才培养模式的重要形式之一,独立学院肩负培养应用型人才的重要责任,加强对学生的创新创业教育是其教学工作的重要内容。本文中,笔者就独立学院在开展创新创业教育过程中面临的问题,以及如何深入有效开展创新创业教育路径进行了分析探究,以期为独立学院开创特色化的创新创业教育带来一定的启发作用。
诊断学“课堂即病房”教学及考核模式研究
Authors: 于 洪江 , 柳 国洪
Published: June 2019

诊断学传统的教学模式不符合“基于职业能力导向”的课程目标要求,为了使教学和考核充分接近临床医生实际工作情境和助理执业医师技能考试,研究新的教学模式非常必要。“课堂即病房”教学及考核模式,包括教学模式介绍和设计、考核模式介绍和设计,教学和考核中重点、难点问题所在及解决方案。可操作性强,符合职业能力的要求,可实现教学过程与实际工作需要对接,符合现代职业教育的精神。
浅谈高职院校学生参加创新创业大赛的意义
Authors: 董 科 , 杨 洋
Published: June 2019

在双创热潮的引领下,高职院校积极参与各类创新创业大赛,双创大赛已成为培育大学生双创能力的一个有效切入点。高职学生参加双创大赛,不仅打开了素质培育、创新型人才培养渠道,而且引起了社会各界及高校对双创教育的思考与重视。实践表明,竞赛过程能够直观窥察到学生具备的素质和教育培养现状,能够为教育改革提供方向性和实操性认知。作为一名高职大学生应该积极投入到双创大赛的热潮中。
多方联动优化地方大学生就业服务体系研究——以安阳市为例
Authors: 刘 芳
Published: June 2019

优化大学生就业服务体系主要从政府、高校、社会以及大学毕业生自身的资源统筹配置出发,以保障机制和运行机制建设为核心内容,结合地方实际,联动各方资源,积极建构适合社会发展、大学生需求的高校大学生就业服务体系。
立足学情 构建生本课堂——以“两位数乘两位数的笔算”为例
Authors: 白 常平
Published: June 2019

教学设计要基于学生实际,是“促进有效学习”课堂变革实现从“教”为中心向“学”为中心的课堂转型所积极倡导的重要理念之一。在实际的教学中我们教师要落实好这一理念,让学生的原有经验为新课服务,树立以生为本理念,发挥原认知的积极作用,改变原有经验的负面影响,建构新知。本文以“两位数乘两位数的笔算”教学为例,谈如何立足学情,以学定教,促进学生对概念本质的理解,构建生本课堂。
体育产业专项基金对社会产业链的影响研究
Authors: 肖 李
Published: June 2019

体育产业作为绿色产业、朝阳产业和推动经济转型升级的重要力量,对扩大消费需求、调整产业结构、完善公共服务具有重要作用。我们坚持政府引导和市场推动相结合,创新体制机制,以每年超过20%的速度迅速增长,相较于发达国家相对规模不足十分之一。作为产业发展重要推动力的体育产业基金基本上处于空白,既是问题所在,也是机会与挑战。
大学公共基础课程《概率论与数理统计》教学中的若干问题探讨
Authors: 毛 雪峰
Published: June 2019

本文旨在总结多年来的教学经验,探讨在《概率论与数理统计》这门课程的教学中应该如何提高学生的学习兴趣、增强学习的主观能动性、培养学生的数学素养,开展好启发式和探究式的教学模式。
POS-tagging a bilingual parallel corpus: methods and challenges
Authors: Doval Irene
Published: June 2019

This paper reviews the author’s experiences of tokenizing and POS tagging a bilingual parallel corpus, the PaGeS Corpus, consisting mostly of German and Spanish fictional texts. This is part of an ongoing process of annotating the corpus for part-of-speech information. This study discusses the specific problems encountered so far. On the one hand, tagging performance degrades significantly when applied to fictional data and, on the other, pre-existing annotation schemes are all language specific. To further improve accuracy during post-editing, the author has developed a common tagset and identified major error patterns.
Percepción de la comunicación alusiva al patrimonio cultural en Cartagena de Indias - Colombia
Authors: Rodríguez Martínez Guillermo , Sojo Gómez Jairo , Marroquín Ciendúa Fernando
Published: June 2019

El artículo presenta los resultados del estudio realizado en Cartagena de Indias, durante los meses de enero, febrero y marzo de 2018, en la ciudad de Colombia, se cuenta con la comunicación del patrimonio cultural implementado en Esta zona. Se evidencia la necesidad de ligar las estrategias de educación con las acciones de comunicación centradas en la ciudadanía y su comportamiento. En términos de temas de campaña o de elementos centrales de persuasión, hacer presencia de acciones de comunicación en el sentido de la noción ciudad y lo que implica la experiencia de la cultura. Sin embargo, no hay un objetivo apropiado para los objetivos de la red.
Evaluasi Manajemen Strategi Pada Dinas Tenaga Kerja Kota Bandung Provinsi Jawa Barat
Authors: Ilham Muhammad
Published: June 2019

Abstract

The Manpower Office of the city of Bandung is a regional organization which is tasked with carrying out some of the governmental affairs based on the principle of autonomy and assistance tasks in the field of labor, and has the functions listed in the regional regulation number 05 of 2013 concerning the second change of the Bandung City Regulation No. 13 of 2007, about the Formation and Structure of the Bandung Regional Office. Reporting from the website of the Bandung City Manpower Office, there were 7,343 registered job seekers, and 1,897 available vacancies. Of the total 1,897 job vacancies the number of placements that have been revised by the Bandung City Manpower Office is 1,469. When viewed from the data, there is a high gap between the number of jobs available and the number of work needs. On the other hand, there are a number of job openings that are not optimally distributed with the number of job seekers. This is certainly the basis for the Bandung City Manpower Office to immediately have strategic management to overcome these problems.

With the management strategy of the Bandung City Manpower Office, can determine the direction and objectives of HR management in the city of Bandung so that it can be realized with optimal work needs with job seekers as well as creating human resources in the city of Bandung who are quality and superior in order to answer the challenges in today's globalization era. In Strategic management, it is necessary to have an evaluation that is used to utilize feedback as input for the formation of new strategies in the future because today's challenges or problems are not necessarily the same as tomorrow. One evaluation technique is the balanced scorecard, this evaluation technique is generally used for evaluating profit organizations, but with the development of the present day this evaluation technique is often used by government organizations.

Keywords : The Manpower Office of the city of Bandung, management strategy, evaluation
A Novel Rolling Bearing Fault Diagnosis and Severity Analysis Method
Authors: Chen Yinsheng , Zhang Tinghao , Luo Zhongming , Sun Kun
Published: June 2019

To improve the fault identification accuracy of rolling bearing and effectively analyze the fault severity, a novel rolling bearing fault diagnosis and severity analysis method based on the fast sample entropy, the wavelet packet energy entropy, and a multiclass relevance vector machine is proposed in this paper. A fast sample entropy calculation method based on a kd tree is adopted to improve the real-time performance of fault detection in this paper. In view of the non-linearity and non-stationarity of the vibration signals, the vibration signal of the rolling bearing is decomposed into several sub-signals containing fault information by using a wavelet packet. Then, the energy entropy values of the sub-signals decomposed by the wavelet packet are calculated to generate the feature vectors for describing different fault types and severity levels of rolling bearings. The multiclass relevance vector machine modeled by the feature vectors of different fault types and severity levels is used to realize fault type identification and a fault severity analysis of the bearings. The proposed fault diagnosis and severity analysis method is fully evaluated by experiments. The experimental results demonstrate that the fault detection method based on the sample entropy can effectively detect rolling bearing failure. The fault feature extraction method based on the wavelet packet energy entropy can effectively extract the fault features of vibration signals and a multiclass relevance vector machine can identify the fault type and severity by means of the fault features contained in these signals. Compared with some existing bearing rolling fault diagnosis methods, the proposed method is excellent for fault diagnosis and severity analysis and improves the fault identification rate reaching as high as 99.47%.
Neoadjuvant Pazopanib Treatment in High-Risk Soft Tissue Sarcoma: A Quantitative Dynamic 18F-FDG PET/CT Study of the German Interdisciplinary Sarcoma Group
Authors: Sachpekidis Christos , Karampinis Ioannis , Jakob Jens , Kasper Bernd , Nowak Kai , Pilz Lothar , Attenberger Ulrike , Gaiser Timo , Derigs Hans-Günter , Schwarzbach Matthias , Hohenberger Peter , Dimitrakopoulou-Strauss Antonia , Ronellenfitsch Ulrich
Published: June 2019

The outcome of high-risk soft tissue sarcoma (STS) is poor with radical surgery being the only potentially curative modality. Pazopanib is a multikinase inhibitor approved for the treatment of metastatic STS. Herein, in terms of the German Interdisciplinary Sarcoma Group (GISG-04/NOPASS) trial, we evaluate the potential role of kinetic analysis of fludeoxyglucose F-18 (18F-FDG) data derived from the application of dynamic positron emission tomography/computed tomography (PET/CT) in response assessment to pazopanib of STS patients scheduled for surgical resection. Sixteen STS patients treated with pazopanib as neoadjuvant therapy before surgery were enrolled in the analysis. All patients underwent dynamic PET/CT prior to and after pazopanib treatment. Data analysis consisted of visual (qualitative) analysis of the PET/CT scans, semi-quantitative evaluation based on standardized uptake value (SUV) calculations, and quantitative analysis of the dynamic 18F-FDG PET data, based on two-tissue compartment modeling. Resection specimens were histopathologically assessed and the percentage of regression grade was recorded in 14/16 patients. Time to tumor relapse/progression was also calculated. In the follow-up, 12/16 patients (75%) were alive without relapse, while four patients (25%) relapsed, among them one patient died. Median histopathological regression was 20% (mean 26%, range 5–70%). The studied population was dichotomized using a histopathological regression grade of 20% as cut-off. Based on this threshold, 10/14 patients (71%) showed partial remission (PR), while stable disease (SD) was seen in the rest 4 evaluable patients (29%). Semi-quantitative evaluation showed no statistically significant change in the widely used PET parameters, SUVaverage and SUVmax. On the other hand, 18F-FDG kinetic analysis revealed a significant decrease in the perfusion-related parameter K1, which reflects the carrier-mediated transport of 18F-FDG from plasma to tumor. This decrease can be considered as a marker in response to pazopanib in STS and could be due to the anti-angiogenic effect of the therapeutic agent.
Sugar Transporter Proteins (STPs) in Gramineae Crops: Comparative Analysis, Phylogeny, Evolution, and Expression Profiling
Authors: Kong Weilong , An Baoguang , Zhang Yue , Yang Jing , Li Shuangmiao , Sun Tong , Li Yangsheng
Published: June 2019

Sugar transporter proteins (STPs), such as H+/sugar symporters, play essential roles in plants’ sugar transport, growth, and development, and possess an important potential to enhance plants’ performance of multiple agronomic traits, especially crop yield and stress tolerance. However, the evolutionary dynamics of this important gene family in Gramineae crops are still not well-documented and functional differentiation of rice STP genes remain unclear. To address this gap, we conducted a comparative genomic study of STP genes in seven representative Gramineae crops, which are Brachypodium distachyon (Bd), Hordeum vulgare (Hv), Setaria italica (Si), Sorghum bicolor (Sb), Zea mays (Zm), Oryza rufipogon (Or), and Oryza sativa ssp. japonica (Os). In this case, a total of 177 STP genes were identified and grouped into four clades. Of four clades, the Clade I, Clade III, and Clade IV showed an observable number expansion compared to Clade II. Our results of identified duplication events and divergence time of duplicate gene pairs indicated that tandem, Whole genome duplication (WGD)/segmental duplication events play crucial roles in the STP gene family expansion of some Gramineae crops (expect for Hv) during a long-term evolutionary process. However, expansion mechanisms of the STP gene family among the tested species were different. Further selective force studies revealed that the STP gene family in Gramineae crops was under purifying selective forces and different clades and orthologous groups with different selective forces. Furthermore, expression analysis showed that rice STP genes play important roles not only in flower organs development but also under various abiotic stresses (cold, high-temperature, and submergence stresses), blast infection, and wounding. The current study highlighted the expansion and evolutionary patterns of the STP gene family in Gramineae genomes and provided some important messages for the future functional analysis of Gramineae crop STP genes.
Preclinical Evaluation of 1,2-Diamino-4,5-Dibromobenzene in Genetically Engineered Mouse Models of Pancreatic Cancer
Authors: Goetze Robert G. , Buchholz Soeren M. , Ou Ning , Zhang Qinrong , Patil Shilpa , Schirmer Markus , Singh Shiv K. , Ellenrieder Volker , Hessmann Elisabeth , Lu Qing-Bin , Neesse Albrecht
Published: June 2019

Background: Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to standard chemo- and radiotherapy. Recently, a new class of non-platinum-based halogenated molecules (called FMD compounds) was discovered that selectively kills cancer cells. Here, we investigate the potential of 1,2-Diamino-4,5-dibromobenzene (2Br-DAB) in combination with standard chemotherapy and radiotherapy in murine and human PDAC. Methods: Cell viability and colony formation was performed in human (Panc1, BxPC3, PaTu8988t, MiaPaCa) and three murine LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) pancreatic cancer cell lines. In vivo, preclinical experiments were conducted in LSL-KrasG12D/+;p48-Cre (KC) and KPC mice using 2Br-DAB (7 mg/kg, i.p.), +/- radiation (10 × 1.8 Gy), gemcitabine (100 mg/kg, i.p.), or a combination. Tumor growth and therapeutic response were assessed by high-resolution ultrasound and immunohistochemistry. Results: 2Br-DAB significantly reduced cell viability in human and murine pancreatic cancer cell lines in a dose-dependent manner. In particular, colony formation in human Panc1 cells was significantly decreased upon 25 µM 2Br-DAB + radiation treatment compared with vehicle control (p = 0.03). In vivo, 2Br-DAB reduced tumor frequency in KC mice. In the KPC model, 2Br-DAB or gemcitabine monotherapy had comparable therapeutic effects. Furthermore, the combination of gemcitabine and 2Br-DAB or 2Br-DAB and 18 Gy irradiation showed additional antineoplastic effects. Conclusions: 2Br-DAB is effective in killing pancreatic cancer cells in vitro. 2Br-DAB was not toxic in vivo, and additional antineoplastic effects were observed in combination with irradiation.
Cardiac Rhythm and Molecular Docking Studies of Ion Channel Ligands with Cardiotoxicity in Zebrafish
Authors: Sampurna Bonifasius Putera , Santoso Fiorency , Lee Jia-Hau , Yu Wen-Hao , Wu Chin-Chung , Audira Gilbert , Juniardi Stevhen , Chen Jung-Ren , Lin Ying-Ting , Hsiao Chung-Der
Published: June 2019

Safety is one of the most important and critical issues in drug development. Many drugs were abandoned in clinical trials and retracted from the market because of unknown side effects. Cardiotoxicity is one of the most common reasons for drug retraction due to its potential side effects, i.e., inducing either tachycardia, bradycardia or arrhythmia. The zebrafish model could be used to screen drug libraries with potential cardiotoxicity in a high-throughput manner. In addition, the fundamental principles of replacement, reduction, and refinement of laboratory animal usage, 3R, could be achieved by using zebrafish as an alternative to animal models. In this study, we used a simple ImageJ-based method to evaluate and screen 70 ion channel ligands and successfully identify six compounds with strong cardiotoxicity in vivo. Next, we conducted an in silico-based molecular docking simulation to elucidate five identified compounds that might interact with domain III or domain IV of the Danio rerio L-type calcium channel (LTCC), a known pharmaceutically important target for arrhythmia. In conclusion, in this study, we provide a web lab and dry lab combinatorial approach to perform in vivo cardiotoxicity drug screening and in silico mechanistic studies.
Spatiotemporal Regulation of Rho GTPases in Neuronal Migration
Authors: Xu Zhenyan , Chen Yuewen , Chen Yu
Published: June 2019

Neuronal migration is essential for the orchestration of brain development and involves several contiguous steps: interkinetic nuclear movement (INM), multipolar–bipolar transition, locomotion, and translocation. Growing evidence suggests that Rho GTPases, including RhoA, Rac, Cdc42, and the atypical Rnd members, play critical roles in neuronal migration by regulating both actin and microtubule cytoskeletal components. This review focuses on the spatiotemporal-specific regulation of Rho GTPases as well as their regulators and effectors in distinct steps during the neuronal migration process. Their roles in bridging extracellular signals and cytoskeletal dynamics to provide optimal structural support to the migrating neurons will also be discussed.
Detection of Volatile Organic Compounds Using Surface Acoustic Wave Sensor Based on Nanoparticles Incorporated in Polymer
Authors: Constantinoiu Izabela , Viespe Cristian
Published: June 2019

In this work, surface acoustic wave (SAW) sensors with two types of polymer sensing films, polyethyleneimine (PEI) and polydimethylsiloxane (PDMS), containing embedded ZnO, TiO2, and WO3 nanoparticles (NPs) for detecting volatile organic compounds (VOCs) were produced and studied. The NPs were obtained using the pulsed laser ablation method, with the same deposition conditions used for all three materials studied. After incorporation of the NPs into the polymer, the suspension obtained was deposited using the airbrush method onto the quartz substrate of the sensor. Sensors were tested for four types of VOCs: Ethanol, toluene, acetone, and dichloroethane. Those based on PEI-sensitive films showed a superior sensitivity to those with PDMS. It was also found that the sensors with WO3 NPs had the best results for ethanol, acetone, and dichloroethane. The limit of detection (LOD) of the PEI/WO3 sensor was 6 ppm for ethanol, 15 ppm for acetone, and 9 ppm for dichloroethane. For toluene, the best response was obtained using the PEI/ZnO sensor, which produced a LOD of 9 ppm.
Influence of Laser Colour Marking on the Corrosion Properties of Low Alloyed Ti
Authors: Kosec Tadeja , Legat Andraž , Kovač Janez , Klobčar Damjan
Published: June 2019

In the field of surface treatment, laser colour marking can be used to produce coloured marks on the surfaces of metals. Laser colour markings can be applied to various materials, but on titanium alloys a wide spectra of vivid colours can be achieved. This study presents an analysis of the corrosion properties of laser treated surfaces that were exposed to aggressive environments. Different samples were prepared with laser light of various power intensities and processing speeds. The samples were prepared on low alloyed Ti. Electrochemical, spectroscopic and microstructural analyses were conducted in order to study the properties of the laser treated surfaces. Corrosion testing showed different effects of laser power and production speed on the properties of the laser treated surfaces. It was shown that a high intensity and slow processing rate affect the surfaces by forming oxides that are relatively stable in a corrosive environment of 0.1 M NaCl. Spectroscopic investigations including scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) analyses showed the differences in chemical structure of the surface layer formed after laser treatment. Similarly, microstructural investigations showed different effects on the surface and sub-surface layer of the laser treated samples.
Indications of Genetic Admixture in the Transition Zone between Fagus sylvatica L. and Fagus sylvatica ssp. orientalis Greut. & Burd
Authors: Müller Markus , Lopez Precious Annie , Papageorgiou Aristotelis C. , Tsiripidis Ioannis , Gailing Oliver
Published: June 2019

Two subspecies of European beech (Fagus sylvatica L.) can be found in southeast Europe: Fagus sylvatica ssp. sylvatica L. and Fagus sylvatica ssp. orientalis (Lipsky) Greut. & Burd. (Fagus orientalis Lipsky). In a previous study, based on genetic diversity patterns and morphological characters, indications of hybridization between both subspecies were found in northeastern Greece, a known contact zone of F. sylvatica and F. orientalis. Nevertheless, potential genetic admixture has not been investigated systematically before. Here, we investigated genetic diversity and genetic structure of 14 beech populations originating from Greece and Turkey as well as of two reference F. sylvatica populations from Germany based on nine expressed sequence tag-simple sequence repeat (EST-SSR) markers. Very low genetic differentiation was detected among F. sylvatica populations (mean GST: 0.005) as well as among F. orientalis populations (mean GST: 0.008), but substantial differentiation was detected between populations of the two subspecies (mean GST: 0.122). Indications for hybridization between both subspecies were revealed for one population in Greece. One of the genetic markers showed specific allele frequencies for F. sylvatica and F. orientalis and may be used as a diagnostic marker in future studies to discriminate both subspecies.
A New Algorithm for Medical Color Images Encryption Using Chaotic Systems
Authors: Moafimadani Seyed Shahabeddin , Chen Yucheng , Tang Chunming
Published: June 2019

In this paper, we present a new algorithm based on chaotic systems to protect medical images against attacks. The proposed algorithm has two main parts: A high-speed permutation process and adaptive diffusion. After the implementation of the algorithm in the MATLAB software, it is observed that the algorithm is effective and appropriate. Also, to quantitatively evaluate the uniformity of the histogram, the chi-square test is done. Key sensitivity analysis demonstrates that images cannot be decrypted whenever a small change happens in the key, which indicates that the algorithm is suitable. Clearly, part of special images is selected to test the selected plain-text, like an all-white image and an all-black image. Entropy results obtained from the implementation of the algorithm on this type of images show that the proposed method is suitable for this particular type of images. In addition, the obtained results from noise and occlusion attacks analysis show that the proposed algorithm can withstand against these types of attacks. Moreover, it can be seen that the images after encryption and decryption are of good quality; the measures such as the correlation coefficients, the entropy, the number of pixel change rate (NPCR), and the uniform average change intensity (UACI) have suitable values; and the method is better than previous methods.
A Thermoelectric-Heat-Pump Employed Active Control Strategy for the Dynamic Cooling Ability Distribution of Liquid Cooling System for the Space Station’s Main Power-Cell-Arrays
Authors: Xu Hui-Juan , Wang Ji-Xiang , Li Yun-Ze , Bi Yan-Jun , Gao Li-Jun
Published: June 2019

A proper operating temperature range and an acceptable temperature uniformity are extremely essential for the efficient and safe operation of the Li-ion battery array, which is an important power source of space stations. The single-phase fluid loop is one of the effective approaches for the thermal management of the battery. Due to the limitation that once the structure of the cold plate (CP) is determined, it is difficult to adjust the cooling ability of different locations of the CP dynamically, this may lead to a large temperature difference of the battery array that is attached to the different locations of the CP. This paper presents a micro-channel CP integrated with a thermoelectric heat pump (THP) in order to achieve the dynamic adjustment of the cooling ability of different locations of the CP. The THP functions to balance the heat transfer within the CP, which transports the heat of the high-temperature region to the low-temperature region by regulating the THP current, where a better temperature uniformity of the CP can be achieved. A lumped-parameter model for the proposed system is established to examine the effects of the thermal load and electric current on the dynamic thermal characteristics. In addition, three different thermal control algorithms (basic PID, fuzzy-PID, and BP-PID) are explored to examine the CP’s temperature uniformity performance by adapting the electric current of the THP. The results demonstrate that the temperature difference of the focused CP can be declined by 1.8 K with the assistance of the THP. The proposed fuzzy-PID controller and BP-PID controller present much better performances than that provided by the basic PID controller in terms of overshoot, response time, and steady state error. Such an innovative arrangement will enhance the CP’s dynamic cooling ability distribution effectively, and thus improve the temperature uniformity and operating reliability of the Li-ion space battery array further.