bluuebunny/crossref_metadata_2025 huggingface dataset:
Alleen voor mannen? Het patriarchale rudiment in de reformatorische ambtstheologie
Authors: Jansen H.
Published: June 2021

Arguments for excluding women from church office are often grounded in the theologies of creation and ministry. Creation theology rightly preserves the differences between male and female, as does scientific reflection on the dynamics of gender identity. Reflection on gender issues and ministry in New Testament texts, however, provides strong arguments against headship as the core element of ministry and as the divinely intended destiny of a baptized male. This essay argues that Galatians 3:28 does not preserve but transcends identity differences in the new community of love in Christ. That is, the Bible’s patriarchal thought should be understood from within its own socio-cultural context, and the church’s ministry should express this anti-patriarchal characteristic of the body of Christ.
VIRTUAL LABORATORIUM TEKNIK DIGITAL BERBASIS MOBILE VIRTUAL REALITY
Authors: Triatmaja Adhy Kurnia , Muchlas Muchlas , Wardana Yoga
Published: June 2021

ABSTRACT:Virtual laboratory of digital engineering based mobile virtual reality is a technology that will be change the conventional laboratory. The use of virtual labs can be used for as long as you have an Android computer, wherever and whenever. A technical breakthrough that makes virtual laboratories imitate actual laboratories is the use of virtual reality technology. This thesis applies mobile augmented reality technology to a virtual software engineering laboratory. Until it becomes a functional product, many considerations and processes are required in the application of a virtual laboratory. The results of this study are used as materials for studying the application of virtual digital engineering laboratories using mobile virtual reality technology.ABSTRAK:Virtual laboratorium teknik digital berbasis mobile virtual reality merupakan teknologi yang dapat dimanfaatkan sebagai pengganti laboratorium konvensional. Penggunaan virtual laboratorium dapat digunakan dimanapun dan kapanpun selama memiliki perangkat android. Penggunaan teknologi virtual reality merupakan suatu perkembangan teknologi sehingga membuat virtual laboratorium dapat menyerupai laboratorium yang sebenarnya. Penelitian ini mengaplikasikan virtual laboratorium teknik digital dengan teknologi mobile virtual reality. Dalam mengaplikasikan virtual laboratorium perlu beberapa pertimbangan dan proses yang harus dilakukan sebelum menjadi suatu produk yang dapat digunakan. Hasil dari penelitian ini adalah sebagai bahan untuk mempelajari dalam mengaplikasikan virtual laboratorium teknik digital dengan menggunakan teknologi mobile virtual reality.
Developing E-Learning Media with the Contiguity Principle for the Subject of Autocad
Authors: Hidayat Nur , Hadi Samsul , Basith Abd. , Suwandi Suwandi
Published: June 2021

Technological advances have made possible to reduce limitation of space and time in learning. Students can interact with teachers and other students indirectly without face to face meetings through e-learning media. To create effective e-learning media, factors to be mainly considered are multimedia learning principles, one of which is contiguity. Thus, this study was aimed at developing e-learning media with the contiguity principle and examining its quality. The media were tested for measuring its effectiveness by statistically analyzing the differences in students’ learning achievement and motivation. This study was research and development using quasi experimental techniques whose subject is Vocational High School also known as Sekolah Menengah Kejuruan Negeri 2 Yogyakarta. The result of this study was e-learning media with the contiguity principle. The feasibility evaluation showed that the product had good quality in the aspects of media and materials. The effectiveness testing showed insignificant differences in learning achievement and motivation between the students using e-learning media with the contiguity principle and without the contiguity principle with the scores of 0.325 and 0.873 respectively.
Development of Learning Media for the Course of Two-Stroke Gasoline Motors to Improve Students’ Learning Outcomes
Authors: Suyitno Suyitno , Widianto Iis , Masrul Suryaneta Binti
Published: June 2021

Learning media of cylinder head cutting for 2-stroke gasoline motors are still limited. The students usually receive the materials only from lectures while the practices used uncut motorcycle props. Subsequently, the students hardly understand the form and the functions of the components. This study aimed at (1) developing the instructional media of two-stroke gasoline motors to improve the students’ learning outcomes, and (2) analysing the feasibility of the developed instructional media. This study was Research and Development. The subject of this study consisted of the 2nd-semester students of Universitas Muhammadiyah Purworejo in the academic year of 2016/2017. The data collection used a questionnaire and a test. The data were analysed using a descriptive analysis technique. The research results showed (1) the developed instructional media was feasible to be applied as instructional media,  and (2) the data analysis results of the control class and the experiment class reached the mean scores of 75.80 and 83.25 respectively. It means there was a significant difference between students using the developed instructional media and those who did not.
Development of an Android-Based Reward System to Enhance the Activity of Learning
Authors: Basori Basori , Isnaini Ratih , Setyowati Anisa , Phommavongsa Deuansvanh
Published: June 2021

The students’ learning activity is an influential factor in the success of learning. New technology can be used to design applications to facilitate the learning process. The objectives of this study were (1) to produce a reward application system to improve the students’ activity, (2) to examine the feasibility of the developed application, and (3) to analyse the difference and the effectiveness of the application in learning compared to conventional learning. This study used the development research method adopting the 4D (define, design, develop, disseminate) model. The application was tested using ISO 25010 standards by media experts, teachers, and ten students of class X Axioo in Vocational High School also known as Sekolah Menengah Kejuruan Negeri 5 Surakarta. The effectiveness was tested using an experimental design. This study produced a proper and an efficient reward system application. The feasibility of the application for functionality, portability, usability and efficiency were 100%, 100%, 86.2% and 77% respectively. The results showed different effectiveness in learning activities between learning using the reward system application and using the conventional model.
Evaluation of Five-Day School Program Implementation Using the Model of Contex, Input, Process, and Product
Authors: Suharno Suharno , Harjanto Budi , Handayani Nita Murtia , Sutanti N.
Published: June 2021

This study aimed at evaluating the implementation of a five-day working program at vocational high schools. This study described the implementation, strengths, and weaknesses of the five-day working program in vocational high schools using a descriptive evaluative method with the model of Contex, Input, Process, and Product. This study was conducted in Vocational High Schools also known as Sekolah Menengah Kejuruan Negeri 2 Karanganyar. The sample of this study consisted of 126 students selected with a quota sampling technique and 10 teachers selected with a purposive sampling technique. Data were collected through observation, questionnaires, interviews, and documentation. The validity of the questionnaire item used logical validation. The results showed that the implementation of the five-day school program was sufficient but not fully achieved. The program can improve students' knowledge and skills and students’ activities are easier to be controlled. In the other hand, the school’ readiness to implement the five-day school program is not optimal indicated by not all teachers use interesting learning media and methods, and the teachers’ teaching performance during the day is decreased.
The Relationship between Training Climate and Self Efficacy to the Effectiveness of the Implementation of ISO 14001 Environmental Management System Training
Authors: Purwoko Sidiq , Kusrini Ina , Musoddaq M. Arif , Hermawan Hardika Dwi
Published: June 2021

The environment is an inseparable element of human health.  A good environmental management will bring benefit to human and surrounding. The successful implementation of International Standardized Management System (SML) ISO 14001 is determined by various factors and one of the factors is training. The purpose of this study was to analyze the correlation of training climate and self-efficacy to the effectiveness of ISO 14001 SML training. This study was categorized as a quantitative type with a cross-sectional design. The population consisted of participants with the total sampling of 90 respondents. The research variables include the training climate, self-efficacy and the effectiveness of the training. This study was conducted in PT XYZ, one of the manufacturing company in Jakarta. The results indicated that training climate and self-efficacy promote the effectiveness of the training with the percentages of 46.7% and 51.1% respectively. The prevalence of ratio that increases the opportunity for practical training is managers’ support (12.9), mastery experience (5.7), and opportunities to use learned abilities (0.2). In conclusion, the climate training and self-efficacy show a positive relationship with the effectiveness of training
E-Instructional Multimedia in Basic Concepts of Electrical and Electronic Lessons
Authors: Budiastuti Pramudita , Khairudin Moh. , Azman M.N.A
Published: June 2021

Interactive learning media facilitate students to be understand and comprehend certain contents of engineering subjects. Therefore, this study aimed to develop e-instructional multimedia for students in the subject of basic electronics and electricity using adobe flash CS 5.5. This subject was selected to support the teaching-learning process at the Vocational Secondary Schools. There were five stages during the development of the learning media, including (1) analysis, (2) design, (3) development, (4) implementation, and (5) evaluation (ADDIE). Furthermore, 30 students in total were selected to test the media practicability. The results revealed that this multimedia is acceptable based on five criteria: creativity, affectivity, efficiency, interestingly, and interactivity with the scores of 76.8, 76.8, 71.5, 77.4, and 74.4 respectively. This study suggested the implementation of the e-instructional multimedia for further understanding its empirical application.
Self-Reliance through Innovation and Entrepreneurship Competency of Technical/Engineering Polytechnic Students in Nigeria
Authors: Jwasshaka Shirka Kassam , Mohd Amin Nor Fadila , Dogara Gimba
Published: June 2021

The study aimed at assessing the adequacy of innovative and entrepreneurial competency of Technical /Engineering students of Plateau State Polytechnic for self-reliance. It was primarily sought to determine whether they were opinions of final year Technical and engineering students.  A descriptive survey design was adopted where 120 respondents were randomly selected from the School of Technical Education and Engineering. 45 items structured questionnaire was used for the collection of data related to innovation and entrepreneurship competency in order to be self-reliant. The instrument was validated by three experts; two from Plateau State Polytechnic and one from the private sector. Data were analyzed using the descriptive statistic to determine the mean and the standard deviation of respondents. The findings of the study revealed that final year students need innovative and entrepreneurial competencies for self-reliant after graduation. The study also showed that the training provided is not sufficient for the prospective graduates to be able to face the challenges in the myths of job scarcity. Recommendations based on the findings of the study was highlighted which includes the need for a complete overhauling of Technology Education curriculum to reflect the current realities.capable of setting up small-scale business after graduation. Three research questions were formulated to seek
Mobile Learning Based on Guided Inquiry: Optimization of Students’ Motivation
Authors: Wirawan I Made Agus , Sunarya I Made Gede , Jayendra I Gusti Nyoman Tri , Yudianto Aan
Published: June 2021

The learning media must be able to guide the students in every stage of learning to improve the students' activity in learning. Based on this problem, this study aims to: (1) design and implement the application of Mobile-Based Learning Based Learning for Computer Assembly Learning in Class X TKJ SMK N 2 Seririt. (2) determine the students’ motivation to Mobile Learning Based Guided Inquiry Application for Computer Assembly Lesson in Class X TKJ SMK N 2 Seririt. The method used in this study was the Waterfall model. Subjects in this study were the students of class X TKJ SMK N 2 Seririt. The results of this study are applications that use the Java programming language with the editor of Android Studio. All the features contained in this educational media work well. Students’ motivation using Mobile Based Guided Inquiry for Computer Assembly Lesson in Class X TKJ SMK N 2 Seririt is in a very good category
The Correlation of Higher Order Thinking Skills and Work Readiness of Vocational High School Students
Authors: Hasan Arsyadani , Pardjono Pardjono
Published: June 2021

Higher Order Thinking Skills (HOTS) are required to face a fast-changing and unpredictable situation or condition in the future. This study describes the HOTS profile of Vocational High School (VHS) students in Surakarta and its correlation with the work readiness in the field of mechanical engineering. The students’ HOTS data were collected through the lathe technique examination, which has been tested empirically and validated by the subject matter. The result of the study showed that the HOTS profile of VHS students of mechanical engineering categorized as high, moderate and low were 36.81%, 18.68%, and 44.5% respectively. The higher thinking level of VHS students showed that students' work readiness was also higher. This means that HOTS was related to psychological, physical, and experiential aspects of the students. The result of HOTS profile could be used by the VHS teachers as the  basis to provide high quality lessons to produce graduates equipped with HOTS and better competitiveness and professionalism in workplaces.
Factor Analysis of the Challenges and Strategies for Effective Work-Based Learning in Nigerian Technical and Vocational Education
Authors: Haruna Rabiu , Bin Kamin Yusri
Published: June 2021

This study investigated challenges and strategies for effective work-based learning in Nigerian technical and vocational education (TVE) using a factor analysis approach. Through the use of structured questionnaire, the opinions of 385 respondents consisting of 227 TVE lecturers and 158 supervisors of technical and vocational firms were sought. The data collected were analyzed using descriptive statistics and varimax rotated principal component factor analysis with factor loading of 0.40. The result showed that about 25% of the TVE firms in Northwest Nigeria are industrial technical firms, 22% are computer/ICT, 19% are business/distributive trade, 18 % are home economics while about 16% are agricultural based. Using principal component factor analysis, the study identified: policy, funding, attitudinal and linkage as challenging factors undermining effectiveness of work-based learning in Nigerian TVE. On the other hand, training, administrative, institutional and facility/curriculum are strategic factors for effectiveness of work-based learning in Nigerian TVE. Based on the findings, the study among others recommended strong technical and vocational education linkage with industry for skills training of students through work-based learning framework and approach
Analysis of Programming Skills Concept in Developing Problem Solving Skills
Authors: Harimurti Rina , Ekohariadi Ekohariadi , Munoto Munoto , Asto B I Gusti Putu , Winanti Elizabeth Titiek
Published: June 2021

Programming refers to a set of processes of writing, testing and correcting the program code aimed at creating a program that can do certain works in accordance with the programmer’s instructions, it requires the mastery of algorithms, logic and programming languages. This study discusses the concept of programming skills to develop problem solving skills, which focuses on secondary school students. Various activities allow students to collaborate and develop problem solutions. Some previous studies suggest that students can obtain knowledge and programming skills through formal and non-formal education even though formal education shows better results of students’ attainments. Given a basic programming skills, students are expected to have a high level of reasoning for their better problem solving skills to solve complex problems using computers through an integrated approach between thinking skills and computational thinking (CT). Computer programming has the effect of reasoning abilities for students, problem solving and self-efficacy. Currently, programming-based computation has been introduced in school curriculum at different levels. Consequently, teachers are required to teach relevant materials relevantly to the current curriculum.
Effect of Work-Based Learning Model on Students’ Achievement Motivation
Authors: Sudjimat Dwi Agus , Permadi Luchyto Chandra
Published: June 2021

This study determines the effect of the Work-Based Learning (WBL) model on achievement motivation of students in the Study Program of Mechanical Engineering at Vocational High Schools (VHS) compared to the Training Within Industry (TWI) model. This study used a quasi-experimental research method with a factorial design in two groups of XII grade vocational high school students of mechanical engineering. The data in the form of achievement motivation was collected using a questionnaire. The data were analyzed using two way Anova technique with α of 0.05. The results showed that (1) the students taught using the WBL model had a significantly higher achievement motivation than the achievement motivation of students taught using the TWI model; (2) students with high prior knowledge had a significantly higher achievement motivation than the achievement motivation possessed by students with moderate and low prior knowledge; and (3) there is an interaction between the use of learning models and students' prior knowledge towards students' achievement motivation. The findings indicated that the WBL model has the potential to improve the quality of learning outcomes of vocational education, especially in increasing students' achievement motivation, compared to traditional learning using the TWI model.
A Need Analysis on Character-Based Campus Television to Support the Integrated Laboratory of Learning Technology
Authors: Soenarto Sunaryo
Published: June 2021

The role of Campus Television (TV) in a university can integrate human resources and audio visual laboratory facilities in each faculty, especially to face today’s digital communication era. The objectives of this study were: (1) to determine the academic community's needs for Campus Television media in Universitas Negeri Yogyakarta (UNY) based on faculties, and the academicians status and (2) to map program types broadcasted by the Campus TV in UNY that were expected by UNY academic community. A survey to the academic community in UNY (consisted of lecturers, employees, and students) was conducted as the research method. Electronic-based questionnaires and smartphones with Google form applications were used as the technique in the data collection. The research subjects were 409 respondents. The data analysis technique was descriptive quantitative. This study concluded that (1) lecturer who agreed and doubted about the existence of Campus TV in UNY were 97.33%, and 2.66% respectively; (2) Employees who agreed was 100%; and (3) Students who agreed, doubted, and disagreed about the existence of Campus TV in UNY were 92.63%, 6.31%, and 1.02% respectively. Campus TV broadcasting programs required by the academic community in UNY included: (1) innovative work programs, (2) campus information, (3) campus activity programs (community service, teaching practice, conference), (4) talk show and (5) skills program. This study provided encouragement to academic community of UNY to support the realization of Campus TV as the integrated laboratory for learning technology.
Go-Byar Based on Virtual Reality for the Learning Media of Gamelan
Authors: Dwipayana Kadek , Wirawan I Made Agus , Sindu I Gede Partha
Published: June 2021

Gong Kebyar is one of the group of Balinese music that has five pelog tones which the playing technique using kebyar system. Gong Kebyar serves the instrumental performances, accompanying various types of dances, and accompanying Himdu's religious ceremonial activities in Bali. But not many young people can play the gong kebyar due to lack of adequate facilities. One effort that can be done is to utilize virtual reality technology as an instructional media for playing Gong Kebyar. The purpose of the study was to design and implement the design of Gamelan Gong Kebyar based on Virtual Reality.The development of the Gamelan Gong Kebyar Game based on Virtual Reality was implemented using the ADDIE model. The main feature of this game was playing the gamelan Gong Kebyar instrument, besides that there is a feature playing the instrument accompanied by the song so that the player could feel the situation of playing it in form of sekaa. The design is using a functional model which is UML (Unified Modeling Language) and implemented using programming language C# which edited by MonoDevelop-Unity. The results of this study is a Gong Kebyar application based on virtual reality which is operated with a computer and HTC VIVE VR device. All features in this application function properly. With this application, the community can learn to play Gong Kebyar with the results of the user response test obtaining a value of 91%, which means it is included in the excellent category.
RETRACTED: Learning Model Development for Vocational Education Based on Industry Work Culture
Authors: Widarto Widarto
Published: June 2021

Following a rigorous, carefully concerns and considered review of the article published in Jurnal Pendidikan Teknologi dan Kejuruan entitled “Learning Model Development for Vocational Education Based on Industry Work Culture” Vol 25, No 2, pp. 213-218, October 2019DOI: 10.21831/jptk.v25i2.27227 This paper violates the Jurnal Pendidikan Teknologi dan Kejuruan Publication principles and has been retracted. The editor investigated and found that the paper has been published in the Journal of Physics: Conference Series Volume 1273. The document and its content have been removed from Jurnal Pendidikan Teknologi dan Kejuruan, and reasonable effort should be made to remove all references to this article.
Effect of Activity-Based and Challenge-Based Learning Approaches on Technical Colleges Students’ Psychomotor Achievement in Furniture Craft Technology
Authors: Hassan Abdullahi Muhammad , Mohammed Abdullahi Shaba
Published: June 2021

This study adopted the quasi-experimental research design, precisely, pre-test, post-test nonequivalent control group design. The population for the study was 210 National Technical Certificate (NTC II) furniture craft technology students (175 males and 35 females) in Technical Colleges. This study was carried out in Zamfara and Katsina State. The analysis was guided by three research questions and three hypotheses at 0.05 level of significance. The data were obtained with Furniture craft technology Cognitive Achievement Test (FTCAT) and Furniture craft technology Interest Inventory (FTII). The lesson plan, FTCAT, and FTII were subjected to face and content validation by three experts. The instrument was trial tested on a sample of 22 NTC II furniture craft technology students of Government Technical College FCT-Abuja. Kuder-Richardson 20(K-R20) and the Pearson product-moment correlation coefficient were utilized to establish the coefficient of internal consistency and stability of the FTCAT. The values were found to be 0.72 and 0.81 respectively. Data obtained from the administration of the instrument was examined with mean to answer the research questions and Analysis of Covariance (ANCOVA) statistic was used to test the hypotheses. The results showed that the Challenge-based learning approach is more successful in enhancing the students' achievement in furniture craft technology than the Activity-based learning approach. It was recommended that the Ministry of Education and National Board for Technical Education (NBTE) should organize workshops, seminars and in-service training for technical teachers regularly
Contribution of TPACK for a Pedagogical Capability in the Vocational Pre-service Teachers for Electrical Engineering Education
Authors: Putro Setiadi Cahyono , Hidayat Wahyu Nur , Jiono Mahfud , Nidhom Ahmad Mursyidun , Syarif Junaidi
Published: June 2021

The objective of this study was to reveal the correlation and contribution of Technological Pedagogical Content Knowledge (TPACK) for a pedagogical capability of vocational preservice teachers. The research method used quantitative with a descriptive correlational research design. The research sample consisted of electrical engineering undergraduate students in the Faculty of Engineering at Universitas Negeri Malang. The total samples implemented in this study were 135 students. The data collection used a questionnaire and documentation technique. The reliability of the TPACK questionnaire instrument was 0.972 (Alpha Cronbach). The analysis data technique used the analysis of simple regression. The results of the study revealed a positive correlation and a significant correlation between TPACK and Pedagogical Capability with R = 0.757 (psig 0.000 <0.05). The contribution of TPACK to Pedagogical Capability in the Vocational Preservice Teacher was R2 = 0.573.
Policy Shift to Reduce Unemployment of Vocational School Graduates in Indonesia (A National Study)
Authors: Ohara Eric , Harto Slamet Prawiro , Maruanaya Rita Fransina
Published: June 2021

One of the enduring issues and problems in Indonesia is the link and match between vocational secondary schools and the world of work in terms of quantity, quality, location, and time. This research focuses on the first issue i.e. quantity of vocational secondary school graduates in terms of supply and demand. The objective of this research was to explore the proportion of general secondary and vocational secondary school students, to find out the unemployment rate of both school types, and to identify policy alternatives to reduce the unemployment rate of vocational secondary school graduates. To achieve the objective, a quantitative descriptive research method was adopted. The research found that the national average proportion of students from general secondary schools and vocational secondary schools was 62.92%:37.08% in 2016 and 63.39%:36.61% in 2019. The national average unemployment rate of both school graduates was 8.72% and 11.11%% respectively in 2016, and 7.92% and 10.42% respectively in 2019. Thus, the unemployment rate of vocational secondary school graduates was higher than those of general secondary school graduates. In Java Island, however, where the population is about 40% of the Indonesian total population, the percentage of vocational secondary students increases significantly from 44.34%:55.66% in 2016 to 39.91%:60.09% in 2019. For this reason, a new policy is needed to reduce the unemployment rate of vocational secondary school graduates in the form of a moratorium for vocational secondary school expansion, particularly in Java Island. If for some reason, there is a need to build new vocational secondary schools in a certain area, it must be based on demand-driven guided by labor market signals. More comprehensively, a policy shift is required to reduce the unemployment of graduates from secondary vocational schools.
COMPREHENSIVE ASSESSMENT OF ENDOTHELIUM-DEPENDENT MEDIATORS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2
Authors: Zaikina T. S. , Kravchun P. G. , Minukhina D. V. , Minukhin D. V. , Yevtushenko D. O. , Kudrevych I. O.
Published: June 2021

The aim of study is to evaluate the levels of endothelium-dependent mediators: endothelial nitric-oxide synthase (NOS), plasminogen activator inhibitor-1 (PAI-1) and circulating soluble CD40 ligand (sCD40L) in patients with acute myocardial infarction (AMI) and concomitant type 2 diabetes mellitus (DM). The study included 255 patients with AMI, who were divided into two groups depending on the presence of concomitant type 2 DM: 1 group — 143 patients with concomitant type 2 DM; 2 group — 112 patients without concomitant disturbances of carbohydrate metabolism. Studied endothelial-dependent indicators were investigated using enzyme-linked immunosorbent assay. Statistical data were processed using the Mann–Whitney U-test, quantitative variables were described by the following parameters: median (Me), 25th and 75th percentiles (Q1; Q3). Analyzing the studied indicators on admission of patients to the hospital, a statistically significant decrease in NOS levels (p < 0,01), as well as an increase in PAI-1 (p < 0,01) and sCD40L (p < 0,01) in the cohort of patients with AMI and concomitant type 2 DM compared with patients without disturbances of carbohydrate metabolism. This indicates a more significant violation of endothelium-dependent vasodilation, thrombin fibrinolysis and activation of intravascular inflammation caused by comorbidity. Over the next 10 days, an increase in NOS levels, a decrease in PAI-1 and sCD40L levels were observed in patients of both groups, indicating a gradual improvement of the endothelial function. However, in patients with AMI and concomitant type 2 DM, the levels of the studied endothelium-dependent mediators continued to differ statistically even on the 10th day after acute occlusion of the coronary artery. In our opinion, this tendency is caused by the negative impact of metabolicdisorders associated with type 2 DM on the endothelium of the coronary arteries in patients with insulin resistance and, apparently, may increase the risk of complications of AMI.
СТАН МІНЕРАЛЬНОГО ОБМІНУ ТА МЕТАБОЛІЧНОЇ ФУНКЦІЇ КІСТКОВОЇ ТКАНИНИ У ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ В ПОЄДНАННІ З ОЖИРІННЯМ
Authors: Залюбовская О. І. , Трифонова Н. С. , Крапівко С. О. , Наріжна А. В.
Published: June 2021

Натепер існує багато дискутабельних питань щодо впливу ожиріння (ОЖ) та цукрового діабету (ЦД) 2 типу на кістковий метаболізм, який обумовлює мінеральну щільність кісткової тканини. На думку деяких дослідників, ОЖ є пусковим фактором, найбільш частим і раннім маркером порушень цих процесів. Інші науковці вважають, що ОЖ, є в деякій мірі фактором захисту кісткової тканини, яке обумовлює збільшення мінеральної щільності кісткової тканини.

 Натепер достатньо інформативними показниками, які характеризують процес кісткового ремоделювання, вважаються вміст у крові кісткового ізоферменту лужної фосфатази, добовий рівень екскреції дизоксипирідиноліна, N-остеокальцин крові. Але слід зазначити, що більша частина досліджень щодо кісткового метаболізму при ОЖ та ЦД 2 типу присвячена вивченню цього питання у жінок, які знаходяться у післяменопаузальному періоді, тоді як періменопаузальному періоду приділяється недостатньо уваги. Не має однозначних даних і щодо статевих відмінностей у кісткового метаболізму у осіб віком до 50 років із ОЖ та ЦД 2 типу.

Метою даного дослідження стала деталізація статевих особливостей маркерів, що характеризують процес кісткового ремоделювання та мінерального обміну, хворих на цукровий діабет 2 типу в поєднанні з ожирінням.

В ході дослідження проведено обстеження 71 хворого віком від 42 до 50 років із ОЖ 1–2 ст. та ЦД 2 типу (чоловіків/жінок — 29/42). Обстежені знаходились у стані субкомпенсації вуглеводного обміну.

Обстеження пацієнтів включало вимірювання антропометричних показників, розрахунок індексу маси тіла та співвідношення обвід талії до обвіду стегон, дослідження параметрів вуглеводного обміну, визначення 25(ОН)D, рівнів магнію, фосфору, загального та іонізованого кальцію крові. Процеси кісткового формування аналізувалися за вмістом кісткового ізоферменту лужної фосфатази, резорбція кісткової тканини оцінювалася за добовим рівнем екскреції дезоксипіридиноліна. Також визначався рівень N-Остеокальцину (нг/мл).

Аналіз результатів даного дослідження показав, що ще до гормональної перебудови репродуктивної системи у переважної більшості жінок та чоловіків із такою сполученою патологією як ОЖ та ЦД 2 типу формується негативний кістковий баланс внаслідок розладів кальцій-фосфор-магнієвого обміну, на тлі дефіциту вітаміну D.

Доведено, що складні взаємодії розладів мінерального обміну та патогенетичних факторів, які є основою ожиріння та цукрового діабету 2 типу, є умовою формування порушень ремоделювання кісткової тканини з посиленням резорбтивної її активності при недостатньому кістковоутворенні.

Результати даного дослідження є пріоритетними щодо визначення статевих особливостей мінерального обміну та процесів кісткового ремоделювання саме у представників української популяції із ОЖ та ЦД 2 типу.

Важливим доробком роботи є уточнення змін N-Остеокальцину у дослідженої категорії пацієнтів із урахуванням основних антропометричних параметрів обстежених та параметрами вуглеводного обміну.
STUDY OF SPECIFIC ANTIDIABETIC EFFECT OF PERSPECTIVE SIRTUIN-1 ACTIVATOR PYRABENTIN ON THE MODEL OF METABOLIC MEMORY IN RATS
Authors: Krasova N.S. , Gladkih Alexandr , Yaremenko Fedir , Leshchenko Zhanna , Kolesnikova Alla , Gromakovska Olena , Lipson Victoria , Poltorak Victoria
Published: June 2021

Pharmacological activation of sirtuin-1 (SIRT1), which can mimic calorie restriction, reduce fat deposition along with stimulating its utilization, and possibly erase "metabolic memory", is a promising goal for the prevention and treatment of obesity and type 2 diabetes. The aim of the study was to evaluate the specific antidiabetic effect of the original heterocyclic compound with the proprietary name pyrabentin with in situ proven ability to activate human sirtuin-1 on the experimental model of "metabolic memory" in rats.

The study was conducted on adult male Wistar rats (n=24), which were kept on a high-fat diet (HFD) for 5 months, control sex- and age-matched animals (n=6) were received standard diet (StD). At the end of the 5-mo HFD-period, the animals were randomized for the study over the next two months into 4 groups as follows: HFD/HFD+placebo, HFD/StD+placebo, HFD/StD+pyrabentin (PB), HFD/StD+metformin (MF). PB was administered orally at 50 mg/kg body weight as an aqueous suspension with Tween-80 daily, the reference drug metformin was administered in a similar way at 100 mg/kg body weight, the control group received a placebo. Glucose tolerance test and short insulin test were performed, body weight, abdominal adipose tissue weight by fraction and blood pressure were assessed. Shapiro-Wilk test, paired and unpaired Student’s t-test, and Mann-Whitney U-test were used.

It was found that 60-day administration of pyrabentin to rats with a model of "metabolic memory", insulin resistance and obesity, was realized in a statistically significant decrease in basal glycemia, glucose intolerance, body weight and weight of abdominal adipose tissue fractions with comparable efficacy to the reference drug. This was accompanied by improved insulin sensitivity and blood pressure.
КОРЕКЦІЯ РОЗЛАДІВ РЕПРОДУКТИВНОЇ СИСТЕМИ ЩУРІВ ЗА УМОВ ЗМІН СВІТЛОВОГО РЕЖИМУ
Authors: Мамотенко А. В. , Комісова Т. Є. , Іонов І. А.
Published: June 2021

Суперечливий характер сучасних даних щодо динаміки порушень добових ритмів гормональної активності статевих залоз, а також пошук засобів відновлення їх нормального функціонування за допомогою засобів фармакологічної корекції є на сьогодні своєчасним та актуальним. Проведене дослідження мало за мету встановити наслідки деструктивного впливу довготривалих змін режиму освітлення на репродуктивну систему самців щурів та пошук комплексних підходів до її фармакологічної корекції.

У ході дослідження виявлено, що в умовах тривалого освітлення, на тлі послабленого добового ритму, у щурів спостерігається розвиток вираженої мелатонінової недостатності. У самців щурів на фоні світлового навантаження розвиваються глибокі морфофункціональні зміни системи репродукції, які прогресують та поглиблюються із зростанням часу освітлення. Показано, що 12-годинне освітлення призводить до зниження рівня фруктози у сім’яних пухирцях на 24 % (р ≤ 0,05). Цілодобове освітлення викликає ще більш значні відхилення цього показника від контрольних величин — на 49 % (р ≤ 0,05). Кількість та рухливість сперміїв у даних групах теж знижується порівняно з контролем.

Встановлено, що тяжкі наслідки тривалого дефіциту мелатоніну в організмі для функціонування статевих залоз не є незворотними. Отримано експериментальні докази доцільності та високої ефективності застосування препаратів мелатоніну для профілактики гіпогонадизму, в патогенезі якого є тривала мелатонінова недостатність. Так, після самостійного введення мелатоніну в обох групах щурів, що перебували в умовах штучного освітлення, відбувається нормалізація кількісних показників статевих клітин, вірогідно збільшується й відсоток рухливих сперміїв, але, за виключенням їх кількості в гр. 12/12+М, вони не досягають показників контролю. При цьому, вміст фруктози у сім’яних пухирцях зростає, відповідно, на 26 % та 36 % в гр. 12/12 + М та 24/00 + М        (р ≤ 0,05).

Показана більш висока ефективність використаної схеми курсового застосування мелатоніну у комплексі із спіруліною для превентивного зниження ризику репродуктивних розладів. Особливо виразна позитивна дія такого комплексу спостерігається у групі цілодобового штучного освітлення.
СПОСІБ МОРФОЛОГІЧНОЇ ДІАГНОСТИКИ ВПЛИВУ БАКТЕРІАЛЬНОЇ МАТЕРИНСЬКО-ПЛОДОВОЇ ІНФЕКЦІЇ НА ЩИТОВИДНУ ЗАЛОЗУ НАЩАДКІВ
Authors: Талапова П. С.
Published: June 2021

Мета дослідження: задля розширення знань щодо морфологічного субстрату материнсько-плодової інфекції та визначення пов’язаних з нею ризиків під час раннього онтогенезу людини, розробити в експерименті спосіб морфологічної діагностики дії бактеріальної материнського-плодової інфекції на щитовидну залозу (ЩЗ) нащадків.

Матеріали і методи: було проведене контрольоване експериментальне дослідження з блоковою рандомізацією на самицях щурів популяції Wistar Albino Glaxo (n = 85) з наступним патоморфологічним дослідженням 71 ЩЗ, отриманих від їхніх нащадків (37 плодів та 34 новонароджених щурів). Морфометрія та аналіз імунофлуоресцентного дослідження виконувалися у програмі ImageJ. Статистична обробка даних проводилася в програмному середовищі для статистичних обчислень R з підключенням пакетів «ggplot2», «dplyr», «pastecs» та «graphics» задля виявлення мір центральної тенденції і мінливості набору даних, виконання тесту Шапіро-Уілка на нормальність розподілення та перевірки рівності дисперсій декількох вибірок за допомогою критерію Бартлетта, нормалізації даних за методом Бокса-Кокса, виконання однофакторного дисперсійного аналізу (ANOVA) для порівняння середніх значень кількісних величин, апостеріорних порівнянь за методом Бонферроні і проведення тесту Т’юкі для контролю групової ймовірності помилки. Нульова гіпотеза відкидалася у тому випадку за умови p < 0,001.

Результати: проведене дослідження свідчить на користь того, що інфекційна патологія матері є шкідливим фактором для морфофункціонального стану ЩЗ нащадків.

Висновки: на підставі проведеного дослідження пропонується спосіб морфологічної діагностики впливу інфекційної патології матері на щитовидну залозу нащадків, що включає імунофлуоресцентне дослідження маркерів функціонального стану органу з обчисленням оптичної щільності флуоресценції T4, колагенів І й ІІІ типів, TNF та IL-6, а також морфометрію тиреоїдних гістоструктур у програмі ImageJ з визначенням площі та діаметру фолікула, площі та висоти тироциту, площі ядра та цитоплазми тироциту з подальшим розрахуванням ядерно-цитоплазматичного відношення. Використовуючи запропонований метод, можна з високою точністю визначити морфофункціональний стан щитовидної залози як тварини, так і людини. Комплексно, отримані результати є доказом функціонального напруження органу з ознаками клітинного пошкодження, здатного призводити до виснаження адаптивно-компенсаторного резерву щитовидної залози у майбутньому через вплив материнсько-плодової інфекції. Це вказує на необхідність підвищення діагностичної настороженості серед ендокринологів та акушерів-гінекологів стосовно інфекцій, викликаних умовно-патогенною мікрофлорою, у вагітних жінок.
THE ROLE OF OBESIT Y IN THE DE VELOPMENT OF VITAMIN D DEFICIENCY RICKETS IN CHILDREN
Authors: Puhach М. М. , Kolesnyk V. P. , Herasymova O. V. , Mazur O. H.
Published: June 2021

Vitamin D deficiency rickets is one of the most common diseases among children of the first years of life in many countries around the world. It is very important to understand the aforementioned nosological unit as a metabolism disorder, and not just as a D-deficiency state. In modern conditions, the risk factors for vitamin D deficiency rickets have undergone further study. The results of the research indicate that obesity is one of the risk factors for vitamin D deficiency in children. Thus, vitamin D metabolism, deposition, bioavailability and its biological role are dependent on the size of adipose tissue. The pathogenetic interaction between obesity andМvitamin D deficiency is probably predetermined by several mechanisms. Firstly, in case of obesity, vitamin D,Мwhich is a fat-soluble substance, is distributed in a considerable amount of adipose tissue, which leads toa decrease in its concentration in the blood plasma. Secondly, with excessive body weight there is a limitation of vitamin D bioavailability, caused by vitamin D capture with adipocytes and depositing in adipose tissue.Thirdly, there is a genetic proof that the increase in BMI leads to a decrease in vitamin D levels in blood serum.Recent studies have shown that adipose tissue may be the direct target of vitamin D physiological actions.It has been proved that vitamin D can affect obesity through numerous mechanisms, including protein expression, oxidative stress, inflammation and cellular metabolism. Currently, recommendations for treatment and prevention of vitamin D deficiency can be found in international foreign guidebooks whose authors state that obese children need a higher dosage of vitamin D compared to those whose physical development is consistent with age. Understanding the influence of adipose mass on bone tissue during its growth and development is a very important aspect for further health and pharmacotherapy strategies to prevent bone disorders.
Informed Decision-making for Health Insurance Enrollment: Survey Study
Authors: Colón-Morales Coralys M , Giang Wayne C W , Alvarado Michelle
Published: June 2021

Background

Health insurance enrollment is a difficult financial decision with large health impacts. Challenges such as low health insurance literacy and lack of knowledge about choosing a plan further complicate this decision-making process. Therefore, to support consumers in their choice of a health insurance plan, it is essential to understand how individuals go about making this decision.

Objective

This study aims to understand the sources of information used by individuals to support their employer-provided health insurance enrollment decisions. It seeks to describe how individual descriptive factors lead to choosing a particular type of information source.

Methods

An introduction was presented on health insurance plan selection and the sources of information used to support these decisions from the 1980s to the present. Subsequently, an electronic survey of 151 full-time faculty and staff members was conducted. The survey consisted of four sections: demographics, sources of information, health insurance literacy, and technology acceptance. Descriptive statistics were used to show the demographic characteristics of the 126 eligible respondents and to study the response behaviors in the remaining survey sections. Proportion data analysis was performed using the Cochran-Armitage trend test to understand the strength of the association between our variables and the types of sources used by the respondents.

Results

In terms of demographics, most of the respondents were women (103/126, 81.7%), represented a small household (1-2 persons; 87/126, 69%), and used their insurance 3-12 times a year (52/126, 41.3%). They assessed themselves as having moderate to high health insurance literacy and high acceptance of technology. The most selected and top-ranked sources were Official employer or state websites and Official Human Resources Virtual Benefits Counselor Alex. From our data analysis, we found that the use of official primary sources was constant across age groups and health insurance use groups. Meanwhile, the use of friends or family as a primary source slightly decreased as age and use increased.

Conclusions

In this exploratory study, we identified the main sources of health insurance information among full-time employees from a large state university and found that most of the respondents needed 2-3 sources to gather all the information that they desired. We also studied and identified the relationships between individual factors (such as age, gender, and literacy) and 2 dependent variables on the types of primary sources of information. We encountered several limitations, which will be addressed in future studies.
Overcoming the Digital Divide in the Post–COVID-19 “Reset”: Enhancing Group Virtual Visits with Community Health Workers
Authors: Shah Megha K , Gibbs Ashley Christina , Ali Mohammed K , Narayan K M Venkat , Islam Nadia
Published: June 2021

The COVID-19 pandemic created numerous barriers to the implementation of participant-facing research. For most, the pandemic required rapid transitioning to all virtual platforms. During this pandemic, the most vulnerable populations are at highest risk of falling through the cracks of engagement in clinical care and research. Nonetheless, we argue that we should reframe the discussion to consider how this transition may create opportunities to engage extensively to reach populations. Here, we present our experience in Atlanta (Georgia, United States) in transitioning a group visit model for South Asian immigrants to a virtual platform and the pivotal role community members in the form of community health workers can play in building capacity among participants. We provide details on how this model helped address common barriers to group visit models in clinical practice and how our community health worker team innovatively addressed the digital challenges of working with an elderly population with limited English proficiency.