bluuebunny/crossref_metadata_2025 huggingface dataset:
Prospecting the insect model, Galleria mellonella, for gut-related pathobiology
Authors:   , Emery Helena
Published: May 2021

Animal research has contributed immensely to medical and scientific advances over the last century, and continues to play important roles in enhancing our understanding of infectious and non-communicable disease development, and the search for treatments. The mouse, for example, shares ~95% of human genes and is the most widespread vertebrate model in use. Since the late 1980s, there has been several UK and EU directives (e.g., 2010/63/EU) to improve the welfare of animals considered essential for experimentation, and to link directly with the principle of the 3Rs, to Replace, Reduce and Refine animal use. Additionally, animal maintenance, husbandry, compliance with legislation and licencing, and staff training are costly and time-consuming. Hence, there is much to gain from developing alternative in vivo models and complementary in vitro, in chemico and in silico tools. Larvae of the wax moth Galleria mellonella represent one such surrogate to rodents, and have been used successfully to study microbial isolates for virulence traits, putative antibiotic therapies, and more recently, toxicological assessment. There is an abundance of practical and biological advantages to selecting G. mellonella over rodents and traditional non-mammalian fruit flies and nematodes (which are described in Chapter 1), but one area lacking in knowledge is their applicability for studies of gut pathobiology. Therefore, the aim of this thesis was to evaluate the usefulness and accuracy of G. mellonella larvae as a model for gut specific toxins and pathogens when administered through an oral route (gavage). A series of whole-organism (phenotype), cellular, biochemical, microbiological and microscopy methods were used to interrogate the gastrointestinal tract of G. mellonella in the absence and presence of chemicals and microbes known to cause gastropathy in rodents and humans. First, the transferability of the indomethacin restraint/ulcer assay was established in G. mellonella, with levels of tissue deterioration and enhanced leakiness reminiscent of rodents (Chapter 2). Second, the rearing of insects on nutraceuticals Cordyceps sinensis and bovine colostrum alleviated gut damage caused by indomethacin, and improved survival outcomes when challenged with the enteric pathogen Campylobacter jejuni (Chapter 3). Third, oral administration of shellfish poisoning toxins (okadaic acid and azaspiracids 1-3) to G. mellonella, interfered with tissue integrity and microbial stability of the gastrointestinal tract, and produced comparable LD50 levels to their rodent counterparts (Chapter 4). The results presented here go beyond establishing synonymous damage phenomena between G. mellonella larvae and vertebrates (Chapter 5), but adds new knowledge to the structure and function of the lepidopteran alimentary canal, the cytopathology of emerging marine toxins, and how diet invariably influences a host’s capacity to recover from subacute chemical and microbial disruptors.
METROLOGICAL REQUIREMENTS OF WEIGH-IN-MOTION SYSTEMS FOR VEHICLES
Authors:   Lviv Polytechnic National University, Mykyjchuk Mykola , Hut Taras ,   Lviv Polytechnic National University, Lazarenko Nadiya ,   Lviv Polytechnic National University
Published: May 2021

The article analyzes and proposes solutions for metrological support of weight information systems of road vehicles in motion, including the method of classification of WIM systems by purpose and accuracy classes, metrological requirements for them and control methods for testing and verification, as well as the main metrological risks for Weigh-in-motion systems for road vehicles and requirements for determining and calculating reliability.
PROBLEM OF THE COSMIC GRAVITY MEASUREMENT
Authors:   Lviv Polytechnic National University, Сhaban Vasil
Published: May 2021

Based on Newton's adapted law of universal gravitation in the case of moving masses, taking into account the finite velocity of gravity, differential equations of motion of celestial bodies are obtained. The transient process of the precession of the planet's perihelion was simulated for the first time. A new physical interpretation of the celestial phenomenon due to the discovered new component of force in addition to the Newtonian and Lorentz (gravitomagnetic) is given. The problem of measuring a new force has been formed. The results of computer simulation of the precessing perihelion of the planet considering a new force component are discussed.
Psychometric Properties of the Personality Inventory for DSM-5 in a Romanian Community Sample
Authors: CONSTANTIN Ticu , NICUȚĂ Elena G. , GRĂDINARU Diana
Published: May 2021

The Personality Inventory for DSM-5 (PID-5) evaluates 25 maladaptive personality traits proposed in the Alternative Model of Personality Disorders. The questionnaire has been extensively investigated and validated in several languages. The current research sought to examine the psychometric properties of the instrument in a sample of nonclinical Romanian participants (N = 1276). Results indicated excellent internal consistency for the domain level, and very good reliability for the facet level. The assumption of unidimensionality was supported at both the domain and facet levels, apart from Risk Taking. Two domain scoring methods were also compared. One of them takes into consideration all the 25 lower order facets, whereas the other uses only 15 facets. Results show that mean differences across the two scoring methods were small, except for Disinhibition. Moreover, confirmatory factor analyses revealed slightly better fit indices for the model which uses 15 facets only. Lastly, the hierarchical structure of maladaptive personality traits was explored. Results are discussed in the light of previous literature.
"The Effects of Cognitive Behavioral Therapy
on Academic Adjustment among Jordanian Students"
Authors: AL-MSEIDIN Kholoud I. , AL-ZU'BI Mohammad A.
Published: May 2021

"This study aimed to investigate the effectiveness of cognitive behavioural
therapy (CBT) as a counselling program intervention for Academic
adjustment. In the experimental investigation, data was collected from a total of 68 low-achieving female students from one school in Amman city. The students in the experimental group were observed to complement their
regular counselling for academic adjustment with CBT. The researchers used Academic adjustment scale (AAS) at pre- and post-tests. The duration of the study was 16 weeks of two sessions weekly, in which pre- and post-tests were included. ANCOVA was used to explore the findings of the current
study. The findings demonstrated that low-achieving female students in the
experimental group showed better academic adjustment than female students in the control group. The results have significance for reform the counselling educational policies in the Jordanian Ministry of education based on the importance of CBT-Intervention in educational counselling. Additionally, the study suggested relevant recommendations for future research."
Aproximaciones conceptuales para la definición de un índice de especialización turística aplicado a los departamentos de Argentina
Authors: Gordziejczuk Matías Adrián
Published: May 2021

El objetivo del artículo es dar a conocer un índice de especialización turística de carácter multidimensional aplicado sobre Argentina a escala departamental. Para ello se despliega una metodología de naturaleza cuantitativa vinculada al análisis espacial multivariado, el cual requiere de técnicas como la estandarización de indicadores y el cálculo de puntajes de clasificación espacial. La distribución espacial de la medida resumen obtenida se analiza junto con la exposición del ranking de especialización turística departamental. Los resultados contribuyen a subrayar ideas y aportes que vienen siendo formulados desde hace años acerca de la fragmentación territorial del turismo en Argentina, por lo menos hasta los tiempos previos al desencadenamiento de la pandemia por el covid-19.
La Cuestión Malvinas ante la crisis y transición del sistema mundial: perspectivas frente al Brexit
Authors: Bilmes Julián
Published: May 2021

La Cuestión Malvinas enfrenta un escenario geopolítico por demás dinámico y convulsionado, ante la crisis y transición del sistema mundial en creciente profundización, desde la fase Brexit-Trump después de 2016 y la nueva fase que se abre en la actualidad, a raíz de la pandemia de COVID-19. Se aborda en este trabajo cómo se sitúa el sistema Malvinas, Atlántico Sur y Antártida en este marco, y en particular frente a la salida británica de la Unión Europea (UE). Desde una perspectiva geopolítica, y valiéndose de un enfoque sistémico mundial, se analizan las fuerzas en disputa y los posibles escenarios futuros para la Cuestión Malvinas. Se concluye que el Brexit puede implicar tanto una amenaza como una oportunidad para el histórico reclamo argentino de soberanía sobre las islas del Atlántico Sur y espacios marítimos circundantes, según cómo se lo afronte desde el lado argentino.
Construyendo una Geografía Crítica y Transformadora. En defensa de la Ciencia y la Universidad Pública
Authors: Fernandes Bernardo Mançano , Silveira María Laura
Published: May 2021

En el marco del VII Congreso Nacional de Geografía de Universidades Públicas y XXI Jornadas de Investigación y Enseñanza en Geografía, realizado el 9, 10 y 11 de octubre de 2019 en la Ciudad de La Plata, Buenos Aires, el Doctor Bernardo Mançano Fernandes y la Doctora María Laura Silveira fueron los encargados de las conferencias iniciales y finales del mencionado congreso.
Impact of the Covid-19 Pandemic on Anxiety Levels of Medical Students in Pakistan
Authors: Mukhtar M. Ahmad , Hussain Mukhtar , Mukhtar M. Omer , Sajid Muhammad
Published: May 2021

Covid-19 is a communicable infective disease and has been the major current health challenge since it emerged in China in late 2019. Although earlier data analyses of Dawei Wang etc. from 138 hospital of China had shown that its mortality rate is less than 5%, shown (4.3%), major concern is its widespread transmission. The Covid-19 pandemic has adversely affected economics and the mental health of millions worldwide. Fear is the one of the psychological outcomes of pandemic, but the psychological impact of the pandemic was overshadowed by financial and economic impact, which are interrelated. Conducted through an online questionnaire, this study evaluates the anxiety level of medical students of Nishtar Medical University and Multan and Quaid-e-Azam Medical College (QAMC) Bahawalpur in southern Punjab of Pakistan by using fear Covid-19 scale. The research employs the fear scale developed by Ahorsu et al. based on unidimensional 7 items, 5-point Likert scale. This scale is a valid and reliable tool and has been used to assess the fear for Covid-19 in general population. This scale has been used internationally by many researchers to measure anxiety levels. The research correlated the socio demographic variables, such as age, sex, education level and living surroundings, with anxiety levels that would help to redesign curriculum for education and to plan programs to enhance the knowledge of medical students for preventive measures against Covid-19. 577 male and female students from 1st to 5th year of bachelor’s in medicine and bachelor’s in surgery (MBBS) with ages ranging from 17 to 25 years participated in this study.
POST-KEYNESIANISM: EVOLUTION OF KEYNESIAN MACROECONOMICS IN THE 20TH CENTURY
Authors: Artamonova L. N.
Published: May 2021

The article analyzes the development of J.M. Keynes's theory in the second half of the twentieth century due to the works within the new direction of economical science - Post-Keynesianism. It is shown that in free-market economy Keynesian school based of the original Keynesian methodology requires additional studies of state regulation principles and take into account the qualitative changes in the market mechanisms. It is shown that post-Keynesianism has had a significant impact on the subject of research and has taken into account the principles of free enterprise, market pricing, level of price dynamics. All this principles allow realizing the principle of self-regulation of the market mechanism. New approaches to the post-Keynesians role of the state and state regulation combined with the freedom of entrepreneurship are analyzed. Taking into account real changes and economic crises it is necessary to analyze the main directions of development of the Keynesian model of economic regulation with a view to their effective use in shaping economic policy. There are considered the basic directions of development of post-Keynesianism such as Neo-Ricardian theory of value and prices of goods based on direct costs of production in the framework of macroeconomic model by P. Sraffa, information theory of "fundamental" uncertainty of the future by R. Klauder and the theory of financial instability hypothesis by H. Minsky. Their differences within the framework of post-Keynesianism under the subject specialization are considered. It is noted that the development of PostKeynesianism allows to present the latest research in modern Keynesian school within an interdisciplinary approach to economical problems.
UN SECRETARY-GENERAL NORMATIVE CAPABILITY TO INFLUENCE THE SECURITY COUNCIL DECISION-MAKING PROCESS
Authors: Novik D. G. , Plotnikov V. A.
Published: May 2021

The present article studies the issue of the interrelation between the senior UN official - the Secretary-General and the main UN body - the Security Council. The nature of the Secretary-General role is ambiguous since the very creation of the UN. On one hand, the Secretary-General leads the Secretariat - the body that carries out technical and subsidiary functions in relation to other UN Main Bodies. This is the way the Secretary-General position was initially viewed by the UN authors. On the other hand, the UN Charter contains certain provisions that, with a certain representation, give the Secretary-General vigorous powers, including political ones. Since the very beginning of the UN operation the Secretary-Generals have tried to define the nature of these auxiliary powers, formalize the practice of their use. Special place among these powers have the provisions given in the Charter article 99. This article give to the Secretary-General the right to directly appeal to the Security Council and draw its attention to the situation that, in his (Secretary-General's) opinion may threaten the international peace and security. This right was used by some Secretary-Generals during different crises occurred after the creation of the UN. This article covers consecutively the crisis in Congo, Iran hostage crisis and the situation in Lebanon. These are three situations that forced Secretary-Generals Hammarskjold, Waldheim and de Cuellar to explicitly use their right to appeal to the Security Council. Other cases in UN history involving the Secretary-General appealing to the Security Council while mentioning article 99 cannot be considered as the use of the nature of this article in full sense of its spirit. Such cases were preceded by other appeals to the Council on the same situations by other subjects (notably, the UN member states) or other actions that made Secretary-General to merely perform its technical function. The main research problem here is the search for the UN instrument that could grant the Secretary-General with political powers I addition to existing administrative ones. The outcomes of the analysis show that the main instrument of such kind is the UN Charter Article 99. However, the degree of its usage activity is decreasing over time.
CONSTRUCTIVISM GOES QUANTUM: THE APPROACH REFORM
Authors: Alekseeva T. A. , Mineev A. P. , Fenenko A. V. , Loshkariov I. D. , Ananyev B. I.
Published: May 2021

The article deals with the evolution of constructivist paradigm of international relations. The issue is of utmost importance in terms of the search for theoretical alternatives in the IR thinking. First, we are giving basic introduction of constructivism on the basis of historical and hermeneutical approaches. There is no doubt that the paradigm has faced different theoretical challenges and a lot of critics which has to be addressed. The authors reconsider some constructivist theories and notions in Alexander Wendt's works and the way Wendt tried to reinforce and reassure the constructivist paradigm. This allows us to claim that quantum turn in recent Wendt's work was almost inevitable. Second, the article attempts to answer a question whether the fundamentals of quantum physics are relevant when speaking about social and political processes. At first glance, quantum physics approach has nothing in common with the theory of politics and the theory of international relations. However, there are some grounds to believe that certain problem issues of the political science and IR theory are not deadlocks. In the second part of the article we use the unleashed and underestimated potential of analytical philosophy. To conclude, we believe that today there are more questions than answers but the quantum paradigm is expected to be the important part of the political studies and IR theory as well.
Designing Effective Online Orientation Programs for First-Year University Students
Authors: Crozier Nicole
Published: May 2021

While asynchronous, self-paced online orientation programs are not brand new in the field of orientation, transition and retention, COVID-19 forced many institutions to rapidly create a program for the first time to help welcome fall 2020 students. Using the community of inquiry model as a framework, this literature review explores the research related to orientation and online learning in an effort to identify the principles, practices and processes that can help a student affairs professional to design an effective and engaging online orientation program, or enhance an existing program.
The Impact of the COVID-19 Pandemic on Family Engagement
Authors: Daggers Libby , Pontious Mark , Sterritt Kimberly , Williams Benjamin
Published: May 2021

While family engagement professionals are accustomed to engaging a remote population with high expectations, the COVID-19 pandemic brought challenges, opportunities for innovation, and even higher expectations from families. This article is a collection of experiences from four family engagement colleagues in which the authors spotlight the experiences of families throughout the pandemic, the impact of the pandemic on family engagement, and how this period of time may impact institutional approach to family engagement going forward.
Snowbirds Spotted in Cuba: Canadian Jewish Congress on The Global Stage in the 1960s
Authors: Blaff Ari
Published: May 2021

The American Jewish community has historically overshadowed Canadian Jewry. In population size, political prestige, and global influence, the power imbalance between American- and Canadian-Jewish organizations throughout the twentieth century has anchored popular understandings of North American Jewish affairs as one dominated by the U.S. Whereas the American Jewish Joint Distribution Committee (JDC) shepherded international Jewish causes throughout this period, its Canadian analogue, the Canadian Jewish Congress (CJC), never achieved such stature. However, on an island ninety miles from the U.S. coast, the fragile geopolitics of the Cold War conspired to recast this relationship. The Castro Revolution initiated a process which culminated in the severing of U.S.-Cuban ties in 1961, leaving a precarious Cuban Jewish community vulnerable. Canada’s geographic proximity and close institutional ties with American Jewry transformed the CJC’s role as the primary caregivers of Cuban Jewry. Consequently, the sundering of American-Cuban relations elevated the CJC to a position of strategic prominence on the international stage ultimately overshadowing its larger, and more illustrious, cousin to the south in Cuba.
La communauté juive américaine a historiquement éclipsé la communauté juive canadienne. En termes de population, de prestige politique et d’influence mondiale, le déséquilibre de pouvoir entre les organisations juives américaines et canadiennes tout au long du XXe siècle a ancré la compréhension populaire que les affaires juives nord-américaines étaient dominées par les États-Unis. Alors que le American Jewish Joint Distribution Committee (JDC) a dirigé des causes juives internationales tout au long de cette période, son analogue canadien, le Congrès juif canadien (CJC), n’a jamais atteint une telle stature. Cependant, sur une île située à quatre-vingt-dix milles des côtes américaines, la fragile géopolitique de la guerre froide a contribué à modifier cette relation. La révolution de Castro a lancé un processus qui a abouti à la rupture des liens américano-cubains en 1961, laissant une communauté juive cubaine précaire vulnérable. La proximité géographique du Canada et les liens institutionnels étroits avec la communauté juive américaine ont transformé le rôle du CJC en tant que principal allié de la communauté juive cubaine. Par conséquent, la rupture des relations américano-cubaines a élevé le CJC à une position d’importance stratégique sur la scène internationale, éclipsant finalement à Cuba son plus grand et plus illustre cousin du sud.
Confronting BDS in the Classroom: Jewish High School Students Build Community by Watching BDS Demonstrations on University Campuses
Authors: Reingold Matt
Published: May 2021

A practitioner research study was carried out with 31 students who were enrolled in a course on contemporary Israeli society at a Zionist Jewish high school. As part of a unit designed to introduce students to criticisms against Israel, students watched 3 videos produced by the Boycott, Divestment, and Sanctions (BDS) movement and by university student newspapers. The study assessed whether watching videos of BDS behaviours negatively affected the ways that pro-Israel students learned and thought about Israel. Reflective exercises and interviews revealed that the videos did not harm students’ relationships with the country. Instead, while some students reported feeling intimidated and scared by BDS’ tactics, all 31 students reported that watching the videos was crucial for helping them prepare for life after high school and for understanding the criticisms made against Israel. A surprising finding of the study was that many students shared that having the opportunity to discuss BDS together as a group not only helped them better understand BDS but, more importantly, allowed them to feel less alone by forming a community that banded together through the learning of difficult and upsetting content.Une étude par un praticien en éducation a été menée auprès de 31 étudiants inscrits à un cours sur la société israélienne contemporaine dans une école secondaire juive sioniste. Dans le cadre d’un module conçu pour initier les étudiants aux critiques d’Israël, les étudiants ont regardé 3 vidéos produites par le mouvement Boycott, Désinvestissement et Sanctions (BDS) et par des journaux étudiants universitaires. L’étude a évalué si le visionnement de vidéos qui mettaient en scène des manifestations BDS affectait négativement la manière dont les étudiants pro-israéliens apprenaient et pensaient à propos d’Israël. Des exercices de réflexion et des entretiens ont révélé que les vidéos n’avaient pas nui aux relations des élèves avec le pays. Plutôt, alors que certains étudiants ont déclaré se sentir intimidés et effrayés par les tactiques de BDS, les 31 étudiants ont tous déclaré que regarder les vidéos était crucial pour les aider à se préparer à la vie après le lycée et pour comprendre les critiques dirigées à l’endroit d’Israël. Une découverte surprenante de l’étude est que de nombreux étudiants ont partagé que le fait d’avoir l’opportunité de discuter du mouvement BDS en tant que groupe les a non seulement aidés à mieux comprendre le BDS mais, plus important encore, leur a permis de se sentir moins seuls en formant une communauté qui s’est regroupée tout au long de l’apprentissage de contenu difficile et bouleversant.
“Westmount’s Sinai”: Projecting a Jewish Landscape onto Montreal through Fiction
Authors: Toufexis Jesse
Published: May 2021

For Canadian Jewish authors, every peak and every valley, every lake and every island, every forest and every plain, is a potential locus for mythic energy. In this brief article, I wish to offer a glimpse into the implicit means by which Jewish authors project a specifically Jewish landscape onto their surroundings. Through a short study of Chava Rosenfarb’s Edgia’s Revenge and Leonard Cohen’s The Favourite Game, I will explore both authors’ uses of Mount Royal and the Laurentian Mountains as sacred spaces in the tradition of earlier Jewish stories involving mountains and wilderness. These similarities are especially poignant when we consider Cohen and Rosenfarb’s very different experiences of being Jewish in the world—one a wealthy uptown Jew from Montreal and the other a survivor of the Holocaust.Pour les auteurs juifs canadiens, chaque sommet et vallée, chaque lac et île, chaque forêt et plaine, est un lieu potentiel d’énergie mythique. Dans ce bref article, je souhaite offrir un aperçu des moyens implicites par lesquels les auteurs juifs projettent un paysage spécifiquement juif sur leur environnement. À travers une brève étude d’Edgia’s Revenge de Chava Rosenfarb et The Favourite Game de Leonard Cohen, j’explorerai les usages par les deux auteurs du Mont Royal et des Laurentides en tant qu’espaces sacrés dans la tradition d’histoires juives antérieures sur les montagnes et la nature. Ces similitudes sont particulièrement probantes lorsque nous considérons les expériences très différentes de Cohen et Rosenfarb de vivre leur judéité — l’un un juif nanti élevé à Westmount et l’autre une survivante de l’Holocauste.
Analysis of an Off-grid PV System for Disaster Mitigation Scheme in Remote Areas
Authors: Anugrah Pinto , Yunesti Putty , Persada Guna Bangun
Published: May 2021

The main objective of this paper is to present the techno-economic analysis of an off-grid Photovoltaic system, which prepared to support disaster mitigation scheme in remote areas. As a case study, a regency in Mentawai Island, Sumatera Barat is chosen to represent a remote area in a disaster-prone location. The proposed system capacity is 20 kWp PV system as a single electricity source for medical facility in the island. As a tool in this study, RETScreen software was used to analyze the technical, environmental, and economical feasibility analysis. As a base case scenario, the medical facility was supported by a diesel-fueled generator and the PV system can deliver 10.14 MWh of electricity to load annually. Net annual GHG emission reduction of the system is 19.4 ton of CO2 equivalent. With the total initial cost for the whole PV system at USD 41,380, RETScreen simulation result showed that the equity payback of the project is 6.0 years with IRR of 11.9% hence the project is financially viable.
The mechanism for performing tax function of the state and its reflection in the legal norms of the People’s Republic of China and the Japanese satellites in the late 1920s – mid 1930s
Authors: Dudin Pavel Nikolaevich
Published: May 2021

The subject of this research is the social relations arising in the context of performing tax function in the People’s Republic of China in the late 1920s – mid 1930s and their impact upon similar relations formed in the Chinese territories controlled by Japan in the 1930s: Manchukuo and Mengjiang. The object of this research is the tax system of the People’s Republic of China during the so-called “Nanjing decade” (1927-1937), when the Kuomintang Party headed by Chiang Kai-shek in a short time establishes control over a great part of modern China and begins the centralized policy, including in the area of tax legislation. Special attention is given to the key normative legal acts and government branches, which on the national and provincial levels perform tax function of the state. The article is the sequence of research dedicated to tax system and tax law of East Asian countries. The provisions of tax legislation of both the People’s Republic of China and Manchukuo, are introduced into the scientific discourse of legal science for the first time. The scientific novelty also consists in the comparison of legal systems of China and the Japanese satellites with regards to tax legislation and regulation of tax relations. The author comes to the conclusion that with active implementation of the Japanese model, the regulatory framework of Manchukuo and Mengjiang retained the key features of the Chinese law; but unlike the Chinese model, it was more effective.
Investigation of School Administrators’ Technological Leadership in Terms of Gender
Authors: TULUNAY ATEŞ Öznur , AKIN MART Özlem
Published: May 2021

In this study, it was aimed to determine the effect of gender on the technological leadership of school administrators. For this purpose, 31 studies were reached between 2008-2018 years. These studies were analyzed by using the meta-analysis method. The total sample size of the analyzed studies is found as 9867. In the studies analyzed in the meta-analysis, there are two different types of data groups: the technological leadership of the administrators in teachers’ eyes and the technological leadership of the administrators in their own eyes. As a result of the analysis; it has been determined that both teachers and administrators think that male school administrators have higher technological leadership than women (ES = -0.010). In addition to this result, it has been determined that the effect of gender variable on technological leadership is mostly in administrators, but overall effect size is weak in teachers (ES = 0.009) and managers (ES = -0.044).
A Mixed-Method Study on Nurses’ Assessment of Post-Stroke Depressive Symptoms
Authors:   Shantou University Medical College, China, LL Liao , IJ Su ,   Shantou University Medical College, China
Published: May 2021

Background: Stroke is the second leading cause of death in the world and the leading cause of death in China. Post-stroke depression is prevalent, affecting approximately one third of stroke survivors at any given time. However, the depressive symptoms of stroke patients are often overlooked in clinical practice. Objective: The aim is to investigate the knowledge, attitudes, and practice status of nurse clinicians on the assessment of post-stroke depressive symptoms and explore the influencing factors, so as to provide empirical evidence for clinical education related to Post-Stroke Depression (PSD) and the development of nursing clinical pathways for screening. Methods: A self-designed questionnaire is used to survey 298 nurse clinicians in Guangdong Province of China. 12 nurses and nurse managers among the study subjects are purposefully invited to participate in semistructured interviews for in-depth discussion about factors affecting the status of assessment. Results: The total scores of the survey of clinical nurses assessing poststroke depression are (84.76±13.255). The scores of knowledge, attitude, and practice of the survey are (25.08±8.975), (33.33±5.483), and (26.35±6.719) respectively. The results of multiple linear regression analysis show that predominate influencing factors of knowledge include position and whether appropriate training is offered by the employer. Nurses’ attitudes toward assessment are influenced by where they worke. Influencing factors for the practice of assessing PSD symptoms include nurses’ positions, participation in training, knowledge level, and attitudes. Conclusion: The total scores of nurse clinicians in assessing the symptoms of PSD are below average. The current practice needs to be improved.
GenUI: Interactive and Extensible Open Source Software Platform for De Novo Molecular Generation
Authors: Šícho Martin , Liu Xuhan , Svozil Daniel , van Westen Gerard
Published: May 2021

This manuscript describes the development and architecture of the GenUI software platform for integration of molecular generators. The source code for the components of the platform is available in the following repositories:

https://github.com/martin-sicho/genuihttps://github.com/martin-sicho/genui-guihttps://github.com/martin-sicho/genui-docker
A Nanoscale Model System for the Human Myelin Sheath
Authors: Hoffmann Matthias , Haselberger David , Hofmann Tommy , Müller Lisa , Janson Kevin , Meister Annette , das manabendra , Vargas Carolyn , Keller Sandro , Kastritis Panagiotis L. , Schmidt Carla , Hinderberger Dariush
Published: May 2021

Here, we for the first time establish nanodiscs with the challenging lipid composition of myelin of the peripheral or central nervous systems, respectively (PNS and CNS, both containing >40% cholesterol, which so far has been thought to be detrimental for nanodisc formation).Thus, we prove that more complex lipid model membrane systems are in general accessible through nanodiscs and can study protein-lipid interactions in myelin and factors driving myelin formation or degradation using combinations of myelin proteins in a highly controlled lipid environment resembling myelin’s cytoplasmic leaflet. For the functional studies, initial proof-of-principle experiments using myelin basic protein have been performed.
Effectiveness of the WebQuest Strategy-Based Educational Platform and Learning Environment in Acquiring Biological Concepts and Systemic Thinking in the Biology Course among Pre-Service Teachers
Authors: Alebous Tahani
Published: May 2021

This study aims at uncovering the effectiveness of the WebQuest strategy-based learning environment in the teaching of biological concepts and imparting of systemic thinking. The participants of the study, 64 pre-service teachers (students) for the 2020–2021 academic year, were divided randomly into experimental and control groups. WhatsApp groups were used to communicate with the students. To achieve the study’s objectives, a teacher’s manual for biological concepts was prepared following the WebQuest Model; the WebQuests were created using the Zunal computer programmes. Both biological concepts and systemic thinking assessments were prepared and the study tools were tested for accuracy and reliability. To answer the research questions, data were analysed using ANCOVA and MANCOVA. There were significant differences between the average performances of the two study groups on the scale of the acquisition of biological concepts in favour of the experimental group. Additionally, there were significant differences between the average performances of the groups on a scale of systemic thinking in favour of the experimental group. The results encouraged the educational supervisors to hold training courses and workshops for science teachers, training them in the use of the WebQuest strategy in science teaching and urging its implementation in teaching – through individual instruction and publications. The Ministry of Education must play a role in designing and writing the science curricula and provide a guide for the teachers explaining the ways to employ the WebQuest strategy in the process of teaching science.
Los Escalones del Abuelo
Authors: De la Torre Santiago
Published: May 2021

“Los escalones del Abuelo” es la serie fotográfica expuesta en el Museo Archivo de Arquitectura del Ecuador desde el 29 de febrero hasta el 5 de agosto del 2020. Tras varios años documentando la obra arquitectónica de Oswaldo de la Torre (1926-2012), mi abuelo paterno, propongo este ensayo que juega entre la imagen fotográfica y la imagen arquitectónica caminando en la cuerda floja entre sus pares dialécticos: luz – oscuridad, instante – eternidad, recuerdo – olvido, realidad – ficción, presencia – ausencia, entre otros.

Este ensayo propone un recorrido histórico y reflexivo acerca de la herencia arquitectónica cultural, la relación entre la arquitectura la fotografía y la luz y el papel de la fotografía para preservar la memoria.
Risk factors for acquisition of colistin-resistant Klebsiella pneumoniae and expansion of a colistin-resistant ST307 epidemic clone in hospitals in Marseille, France, 2014 to 2017
Authors: Baron Sophie Alexandra , Cassir Nadim , Hamel Mouna , Hadjadj Linda , Saidani Nadia , Dubourg Gregory , Rolain Jean-Marc
Published: May 2021

Background

France is a low prevalence country for colistin resistance. Molecular and epidemiological events contributing to the emergence of resistance to colistin, one of the 'last-resort' antibiotics to treat multidrug-resistant Gram-negative infections, are important to investigate.

Aim

This retrospective (2014 to 2017) observational study aimed to identify risk factors associated with acquisition of colistin-resistant Klebsiella pneumoniae (CRKP) in hospitals in Marseille, France, and to molecularly characterise clinical isolates.

Methods

To identify risk factors for CRKP, a matched-case–control (1:2) study was performed in two groups of patients with CRKP or colistin-susceptible K. pneumoniae respectively. Whole-genome-sequences (WGS) of CRKP were compared with 6,412 K. pneumoniae genomes available at the National Center for Biotechnology Information (NCBI).

Results

Multivariate analysis identified male sex and contact with a patient carrying a CRKP as significant independent factors (p < 0.05) for CRKP acquisition, but not colistin administration. WGS of nine of 14 CRKP clinical isolates belonged to the same sequence type (ST)307. These isolates were from patients who had been hospitalised in the same wards, suggesting an outbreak. Comparison of the corresponding strains’ WGS to K. pneumoniae genomes in NCBI revealed that in chromosomal genes likely playing a role in colistin resistance, a subset of five specific mutations were significantly associated with ST307 (p < 0.001).

Conclusion

A ST307 CRKP clone was identified in this study, with specific chromosomal mutations in genes potentially implicated in colistin resistance. ST307 might have a propensity to be or become resistant to colistin, however confirming this requires further investigations.
Gambaran Kesehatan Dan Kebersihan Rongga Mulut Tokoh Masyarakat Desa X Kabupaten Indramayu
Authors: Monica Grace
Published: May 2021

Pola hidup dari tokoh masyarakat akan menjadi panutan bagi warga masyarakatnya, begitu juga dengan kesehatan rongga mulut yang dimilikinya. Desa X mengalami krisis air bersih sehingga membuat warga desa menggunakan air seadanya untuk melakukan kegiatan sehari-hari. Sebagian besar warga Desa X hanya dapat bekomunikasi menggunakan bahasa daerah mereka dan memiliki kesulitan dalam berbahasa Indonesia. Artikel ini disusun untuk memberikan gambaran mengenai kesehatan serta kebersihan rongga mulut tokoh masyarakat di Desa X, Kabupaten Indramayu dengan harapan di kemudian hari desa ini dapat menjadi perhatian bersama. Digunakan disain potong lintang/cross sectional untuk melihat kondisi kesehatan serta kebersihan rongga mulut tokoh masyarakat Desa X, Kabupaten Indramayu. Kesehatan rongga mulut dinilai dengan index DMF-T (Decay, Missing, Filled Tooth), kebersihan rongga mulut dinilai dengan index PHP (Patient Hygiene Performance Index). Studi melibatkan 14 tokoh masyarakat desa X, yang terdiri dari 6 (enam) pamong desa dan 9 (sembilan) kader PKK. Pemeriksaan dilakukan pada tempat dengan pencahayaan cukup. Pemeriksaan kesehatan rongga mulut hanya dilakukan sekali, sedangkan pemeriksaan kebersihan mulut dilakukan selama 3 (tiga) bulan berturut-turut. Setiap setelah pemeriksaan, para tokoh masyarakat diberikan edukasi mengenai cara menyikat gigi.

Kesehatan rongga mulut tokoh masyarakat Desa X Kabupaten Indramayu adalah 10,4 dengan prevalensi karies 100%. Kebersihan rongga mulut tokoh masyarakat Desa X Kabupaten Indramayu pada bulan pertama adalah 3,4 (buruk), bulan ke-2 adalah 2,9 (sedang), dan bulan ke-3 adalah 2,3 (sedang). Perlu dilakukan pendekatan lebih mendalam dan rutin dengan menggunakan bahasa daerah setempat untuk memberikan edukasi kesehatan gigi dan mulut pada tokoh masyarakat Desa X Kabupaten Indramayu.
SEMANTICIZATION OF ACCENTUAL VARIANTS IN RUSSIAN NOUNS OF THE THIRD DECLENSION: BEYOND THE “SECOND LOCATIVE” CASE
Authors:   Russian Academy of Sciences Institute for Linguistic Studies, Say Sergey S.
Published: May 2021

Some Russian nouns of the third declension have a specialized “second locative” form with the stressed desinence -и. By contrast, the otherwise homophonous genitive, dative and “plain” locative forms of these nouns are believed to have stress on the stem, cf. genitive, dative and “plain” locative те́ни, vs. second locative (в) тени́ ‘(in) the shade’. However, the data from the poetic texts available in the Russian National Corpus indicate that some of the relevant nouns display accentual variation in their genitive and dative forms. This variation statistically reflects semantic contrasts: in particular, nouns denoting substances (грязь ‘dirt’, пыль ‘dust’, кровь ‘blood’) tend to have stress on the desinence -и in contexts denoting fixed attachment or immersion in the substance. Semanticization of these accentual constrasts is arguably triggered by analogy with the locative forms. These findings indicate a nascent feature of +/– attachment, which cross-cuts case paradigms of at least some Russian nouns.
THE EMERGENCE OF ANCIENT GREEK HISTORICAL THOUGHT AND THE ARCHAIC IONIAN SCIENCE
Authors:   Institute of World History, Russian Academy of Sciences, Surikov Igor E. ,   Russian State University for the Humanities
Published: May 2021

Ancient Greek historical thought came into existence in the 6th century B.C. It was the period when two tendencies, the rationalist and mystic ones, struggled with each other in the Hellenic Weltanschauung (world view). Early historians were influenced both by the latter and – especially – by the former, which gave birth to the Archaic Ionian science (Thales, Anaximander). The paper shows that the influence of natural scientists upon historiographers manifested itself, for instance, in the fact that from the works of the latter, starting with Hecataeus, lacked parts devoted to theogony disappear (in Acusilaus, such a part was still present). The author also traces the serious interest in geography among both Greek natural philosophers and first historians. Anaximander made the earliest in Greece geographical map and Hecataeus improved it. The historians of the first generations after Hecateus can be divided into two groups: those who, like Hecateus, had a special interest not only in history, but also in geography, and those who did not. The second group includes the Athenian Ferekides and Gellanik. As for the first group, Charon of Lampsak and Damast of Sigei can be added to it – this line comes up to Herodotus.
Efficiency Analysis for Triple Band RF Energy Harvesting
Authors: YALÇIN Aziz Burak , SARI Filiz
Published: May 2021

In this paper, a multi-band RF energy harvesting circuit is designed. The output voltage and power of the system built at 900 MHz, 1800 MHz and 2450 MHz frequencies are revealed. All simulations in this paper are made using the Advance Design System (ADS) 2017 program. The load resistances that give the maximum power for each frequency are determined and the appropriate load is selected for all three frequencies. Then, the multi-stage Dickson Voltage Multiplier (DVM) from two to six stages is designed and the number of stages giving the maximum power for each frequency is determined using the selected load. L type and π type impedance matching have been applied to obtain the maximum output power in DVM design, which includes this number of stages and has two Schottky diode models (HSMS-2852). Finally, these three circuits are combined and the output voltage and efficiency of the resulting system are analyzed.
ENERJİ ALANINDA YAPILAN AR-GE HARCAMALARININ ENERJİ TÜKETİMİ ÜZERİNDEKİ ETKİSİ: ALMANYA ÖRNEĞİ
Authors: NAIMOGLU Mustafa
Published: May 2021

Almanya’nın 1990 yılına göre 2019 yılında GSYİH’sı %54, yenilenebilir enerji AR-GE harcamaları %99 ve yenilenebilir enerji kullanımı %84811(hidro hariç) artış gösterirken, toplam enerji tüketimi %14 ve toplam enerji kayıpları %415 oranında azalış göstermiştir. Yani Almanya yenilenebilir enerji kullanımını geliriyle beraber yüksek oranda artırmanın yanında toplam enerji tüketimini ve toplam enerji kayıplarını ciddi oranda azaltmayı başarmıştır. Ayrıca aynı dönemde G7 ülkeleri ve Avrupa Birliği ülkeleri arasında ortak olarak yer alan Fransa ve İtalya ülkeleri sırasıyla %7 ve %0.71 oranında toplam enerji tüketimini artırırken, Almanya ise %14 gibi dikkate değer bir oranda toplam enerji tüketimini azaltmayı başarmıştır. Dolayısıyla bu çalışmanın diğer çalışmalardan farkı Almanya’nın ilgili dönemde daha az enerjiyle nasıl daha fazla gelir elde ettiği sorusunun ekonometrik yöntemlerle araştırılmasıdır. Bunu yaparken Almanya için 1990-2019 döneminde yıllık verilerle yenilenebilir enerji, yenilenemez enerji ve nükleer enerji alanlarında yapılan AR-GE harcamaları kullanılmıştır. Bu amaçla yapısal kırılmaların dikkate alındığı Perron (1989) ve Zivot ve Andrews (1992) testleri kullanılarak incelenen dönem boyunca değişkenlerin durağanlığı araştırılmıştır. Sonra uzun dönem ilişkisi Gregory ve Hansen (1996) eşbütünleşme testi ile sınanmış ve eşbütünleşme ilişkisine rastlanmıştır. Daha sonra uzun dönemli ilişki için Geliştirilmiş En Küçük Kareler Yöntemi (FMOLS) ve Kanonik Eşbütünleşik Regresyon (CCR) gibi yapısal değişmelerin kukla değişken olarak modele dâhil edildiği tahmincilerle test edilmiştir. Bulgular, Almanya için uzun dönemde toplam enerji kullanım miktarını en fazla azaltan enerji AR-GE harcaması türünün yenilenebilir enerji için yapılan AR-GE harcamaları olduğunu, en fazla artıran enerji AR-GE harcamaları türünün ise nükleer enerji için yapılan AR-GE harcamaları olduğunu göstermiştir. Almanya’nın 1990 yılına göre 2019 yılında yenilenebilir enerji AR-GE harcamalarını %99 oranında arttırması ve nükleer enerji AR-GE harcamalarını ise %45.46 oranında azaltması elde edilen sonuçları desteklemektedir. Dolayısıyla Almanya için enerji alanında yapılan iyileştirmeler çok önemli fırsatlar sunmaktadır.
Políticas do toque
Authors: Almeida Tarcisio
Published: May 2021

Buscando perseguir e conjugar performativamente as políticas ins­tauradas pelo toque, em suas dimensões clínicas, filosóficas e artísticas, pro­ponho aqui uma reunião de textos elaborados em distintos momentos, com o intuito de prolongar as práticas de trabalho desenvolvidas pelo programa de formação para jovens artistas - Práticas Desobedientes - em curso desde 2019.
Queer therapy, queering therapy: desire in struggle
Authors: Plotegher Paolo
Published: May 2021

Este relato de experiência visa evidenciar a importância das re­des de parcerias multiescalares internacionais no desenvolvimento de um evento científico no âmbito de um Programa de Pós-Graduação em Design, Tecnologia e Inovação. Estas redes de parcerias entre Brasil, Cuba, Estados Unidos, México e Portugal são delineadas a partir de ações interinstitucio­nais, interdisciplinares e internacionais que envolveram o desenvolvimen­to de um evento internacional que contemplou palestras, mesas redondas, apresentação e publicação de artigos bibliográficos e técnicos. Esta experi­ência multiescalar foi atravessada por narrativas plurais que emergiram de diferentes contextos locais e regionais, promovendo uma perspectiva am­pliadora dos horizontes de discussão no campo do Design e suas interfaces com a Arte e a Tecnologia.
inscripción mural como política: (contra) poder en el grafiti de octubre de 2019
Authors: Benalcázar Jácome Vinicio
Published: May 2021

Los primeros días de octubre de 2019 se desarrolló una de las más grandes movilizaciones de las últimas décadas en el país. El presente estudio se ocupa de examinar la intervención con inscripciones gráficas en esos días de protesta. Se revisa la participación política que tuvo el grafiti durante el levantamiento popular en Quito. Este ensayo expone la articulación de lo visual a un proceso social para reflexionar en torno a la política y la visualidad. El artículo explora la disputa de sentidos que se desarrolla en el seno de la producción de procesos visuales contemporáneos como el grafiti.