bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Therapeutic Opportunities of the Tumour Microenvironment in Treating Pancreatic Ductal Adenocarcinoma: A Literature Review
Authors: Dhaliwal Jasmeet
Published: November 2022

Introduction: Pancreatic ductal adenocarcinoma (PDA) is an invasive cancer of the exocrine pancreas with a 5-year survival rate (<8%), highlighting the need for new therapies to increase patient survivability and remission rates. Current treatment options with chemotherapeutics have yielded minimal success, warranting further research into targeting alternative pathways in tumour progression. The complex tumour microenvironment (TME) of PDA contributes significantly to tumorigenesis and may contain promising novel targets. The therapeutic potential of some known TME elements will be explored, namely hypoxia, MMPs, and TGF-β. These options each have their merits and differences, which are crucial to evaluate and assess the trajectory of PDA research in the future.
Methods: A literature review was performed to summarize all available research on the different current therapeutic options and TME components that can be utilized for PDA treatment. The terms "hypoxia," "MMPs," and "TGF- β'' were used as keywords to search databases including Medline, Embase, and CINAHL. These were searched in combination with terms relevant to PDA and TME. Studies that were peer-reviewed and written in English were taken into consideration, with a focus on those that were published between 2017 and 2022.
Results: Each TME element of hypoxia, MMPs, and TGF-β have specific distinctive targets of HIF-1α, TIMP-1, and SMAD-independent pathways, respectively. These present varying mechanisms of action which differ in their efficacies and limitations. Several of these therapies are currently undergoing clinical trials to better understand the role of each inhibitor. Discussion: This literature review provides insight into the current and future treatments for PDA. Exploiting the TME to develop therapeutic interventions presents a promising strategy to inhibit disease progression, yet research done in PDA is still preliminary due to the disease complexity, but it is moving towards a clinical settings.
Conclusion: Accumulating evidence has suggested that several opportunities for targeted therapy in the PDA TME are very promising and not yet thoroughly investigated. This review aids in accessibility by summarizing important information regarding PDA and the necessary further research into targeting the TME to develop a novel therapeutic treatment.
Green marketing for eco-friendly vegetable products at Wanita Tani Karya Manunggal Group
Authors: Sumarmi Saptaningsih , Purwaningsih Okti , Tentua Meilany Nonsi , Wahyuningsih Aprilia Tita , Adilah Muhammad , Andrasari Hani , Astuti Kumala Dewi Retno , Aprilia Nur Azizah
Published: November 2022

Green marketing is a marketing concept that carries the green concept, considering the environment in terms of green products, green prices, green places, and green promotional activities carried out. This service activity was carried out in Sawahan Hamlet, Pandowoharjo village, Sleman district, with the target participants being KWT Karya Manunggal members. This activity aims to increase participants' understanding and apply green marketing from environmentally friendly vegetables produced by KWT activities. Implementing FGD activities is face-to-face, accompanied by questions and answers, and assistance until the product is ready to be marketed. The participants enthusiastically followed the service activities, and KWT Karya Manunggal succeeded in having a logo used as a brand in marketing products. In addition, the team succeeded in obtaining the copyright for environmentally friendly vegetable packaging from DJKI under the Ministry of Law and Human Rights. To expand the market, social media is used to reach a broader range of consumers by presenting images of dancing products, thereby reducing physical contact with consumers.
Food additives learning assistance for students at SMP Katolik Santa Clara Surabaya
Authors: Virly Virly , Kusumawati Netty , Darmoatmodjo Laurensia Maria Yulian Dwiputranti , Kaharso Victor Christian , Suprijono Maria Matoetina , Verawati Maria Magdalena
Published: November 2022

The learning assistance was designed for teachers at SMP Katolik Santa Clara to develop food additives teaching materials for theoretical learning in the classroom and work in the laboratory to give students a deeper understanding of food additives. The methods applied in this learning assistance were assistance in preparing food additives theoretical teaching materials, designing food additives laboratory works, and delivering food additives teaching materials in the classroom. In addition, laboratory work videos on borax and colorants identification in food samples were also made to facilitate independent laboratory work for students at home amid the COVID-19 pandemic. The evaluation results proved that the students gained a thorough understanding of food additives by being able to explain the definition of food additives, mention the types of food additives, identify food additives listed on food packaging, and give examples of additives misused in food products as well as its adverse impacts on health. Moreover, supplementing laboratory works could improve students' understanding of the theoretical materials and provide a new atmosphere for students to learn new knowledge. Accordingly, the food additives materials were delivered to the maximum extent to the students.
Increasing students' interest and knowledge about herbs in elementary school
Authors: Putri Devi Anggraini , Solihah Riyadatus , Mawli Rizka Efi
Published: November 2022

Herbs is not only a potent Indonesian herbal medicine but also the ancestor tried to keep the preservation of herbs. Therefore, knowledge about herbs is important to be preserved from an early age. However, currently, the interest of Indonesian children in consuming herbs tends to decrease. The stigma that herbs is bitter is the reason why herbs is unlikeable. Based on the analysis of the demographic condition in Bangkalan, the quality of education is still low, interest and knowledge about herbs is also low. The purpose of this program is to increase students' interest and knowledge about herbs at SDN Demangan 3 Bangkalan. The methods are socializing, implementing educational games about herbs, and drinking herbs together. Furthermore, students' interest in herbs was evaluated by using a questionnaire. Meanwhile, students' knowledge about herbs was analyzed and evaluated based on the results of the pre-test and post-test. The results of the program showed that students’ interest in herbs increased by 83% after a learning media namely herbs snake ladder game was applied. In addition, students' knowledge about herbs also increased by 76% from 24 respondents. Thus, this program is recommended to increase the interest and knowledge of elementary school students about herbs.
Counseling, health check-up, and nutritional status to improve nutritional health at Al-Fitrah Islamic Boarding School
Authors: Salim Hotimah Masdan , Choirotussannijah Choirotussannijah , Wulandari Devyana Dyah , Handayani Nanik , Masitah Dewi
Published: November 2022

Islamic boarding schools are places of learning for students who focus on Islamic religious education. One of them is the Assalafi Al Fitrah Islamic Boarding School located in the city of Surabaya, with approximately 3,344 students. Based on demographic analysis and the origin of students from various groups, awareness about food security and nutritional health is still lacking and has not been monitored properly. This can be seen from the situation in Islamic boarding schools where the nutritional status of students is still lacking. So, this community service aims to improve the nutritional health of adolescents through counseling, health checks, and the nutritional status of students. From the results of the community service program that has been carried out, it was found that the level of knowledge about adolescent nutrition in students was very good, with the results of the BMI examination, 25% were in normal conditions and 25% were categorized as having obesity-1 nutritional problems. The activity concludes that the level of knowledge of students about balanced nutrition is very good, but it needs to be balanced with the composition of balanced nutrition it needs every day.
STUDY ON THE AMYLOIDOIGENIC POTENTIAL OF NON-SPECIFIC YERSINIA PSEUDOTUBERCULOSIS PORINS
Authors: Rybinskaya T. , Portnyagina O. , Zelepuga E. , Khomenko V. , Kim N. , Chingizova E. , Menchinskaya E. , Glazunov V. , Chistyulin D. , Novikova O.
Published: November 2022

The paper considers the process of formation and properties of amyloid-like aggregates of outer membrane non-specific porins (OmpC and OmpF) of the gram-negative bacterium Yersinia pseudotuberculos in an acidic medium (pH 4.5) at elevated temperature. The dynamics of the formation of amyloid-like aggregates of porins was monitored after two and four weeks of incubation (at 42 °C) and after 3-5 hours (at 90 °C) by staining the samples with amyloid-specific dye thioflavin T, analyzing the spectra of circular dichroism in the far UV region, IR -spectroscopy and confocal microscopy. It was found that in the case of porin OmpC, incubation under mild conditions (42°C) leads to a reversible accumulation of α-helical regions in the protein polypeptide chain. No significant changes are observed in the spatial structure of OmpF porin under these conditions, however, under harsh conditions (95 ºC) amyloid-like aggregates are formed, which are characterized by an increased content of the β-sheet structure. Using IR spectroscopy, it was shown that the conformational rearrangement in the molecule of OmpF porin is associated with a change in the quantity and quality of elements of the β-structure. According to confocal microscopy, the aggregates of the studied non-specific porins can be considered as intermediate products of the amyloidogenic pathway - oligomers. According to the literature data, these oligomers, which precede the formation of mature fibrils, have membranolytic and cytotoxic properties. For heated samples of the studied porins during reconstitution into bilayer lipid membranes, neither pore-forming nor membranolytic activity was detected. With respect to Neuro-2a CCL-131™ mouse neuroblastoma cells, the aggregates of OmpF and OmpC porins obtained after incubation had a higher toxicity compared to the initial protein samples.
EVALUATION OF THE HUMAN BLOOD PLATELETS SENSITIVITY TO AN ACTIVATION AGONIST ADENOSINE DIPHOSPHATE BY SCANNING FLOW CYTOMETRY UNDER CONDITIONS OF ANTIPLATELET THERAPY
Authors: Litvinenko A. , Nekrasov V. , Chetvertak E. , Maltsev V.
Published: November 2022

Cardiovascular diseases occupy a leading place among the causes of death in the population. The main complications of the disease in this group are closely related to changes in the functioning of the hemostasis system, including primary hemostasis. Antiplatelet therapy is used to prevent the development of complications associated with disorders in the hemostasis system. This paper examines the behavior of the platelet population of healthy donors before and after the use of two main types of drugs: acetylsalicylic acid and clopidogrel. Using the method of scanning flow cytometry, the shape index of single platelets was measured, followed by the construction of distributions according to this characteristic for native samples and after exposure to a small amount of an activation agonist. The sensitivity of platelets to the activation agonist is assessed by the change in distributions before and after the application of a short course of therapy. As a result of the assessment, the threshold value for the onset of changes in the shape of platelets and sensitivity increased with the use of acetylsalicylic acid, and decreased with the use of clopidogrel. The demonstrated approach for assessing sensitivity can be useful both in assessing the degree of effectiveness of antiplatelet therapy used and in diagnosing the presence of complications in the course of diseases of the cardiovascular system on the part of primary hemostasis.
PROSPECTS FOR USING DELAYED FLUORESCENCE OF ALGAE FOR CONTAMINATION BIOTESTING
Authors: Matorin D. , Yakovleva O. , Todorenko D. , Goryachev S. , Alekseev A.
Published: November 2022

The nature of the delayed chlorophyll fluorescence (DF) in algae, which occurs already after the cessation of illumination due to the energy released during the reverse reactions of the primary photosynthesis photoproducts in the reaction center of the photosystem 2, is considered. The use of this fluorescence in algae for biotesting of contaminants is shown to be promising. The advantages of using DF for express assessment of water toxicity, especially drinking water, are short durations of tests and, accordingly, the minimized negative impact of physicochemical changes in the medium on the results, as well as the need of small amounts of test objects. The other advantage of DF is that only living cells with active photosynthetic reaction sites are measured, which increases the sensitivity of toxicity tests. This method provides additional information about the most important process in the cell - the energization of photosynthetic membranes and the formation of ATP associated with this.
Editorial in English
Authors: Malak Sonia
Published: November 2022

The International Journal of Law has come out with a new issue confirming its international and comparative identity, in which researchers from different legal schools participated in research on a variety of topics, whether related to national law, international law or comparative law, as the International Journal of Law has been an important platform for attracting quality research work. The Journal is a link between researchers and the audience from different parts of the world. The research of this issue was varied and rich. Following is the list of papers that this issue carries: 1.“Termination and Expiration of Work Contract in the Palestinian Labor Law: A Comparative Study,” by Dr. Ahmad Abdel-Wahab Abu Zeineh. 2.“Implementation of the Principle of Government’s No–Fault Liability on the curfew imposed by the Kuwaiti Government due to Corona Pandemic,” by Munira Alnamash Fatma Almohsen. 3.“The Political Tendencies of the Constitutional Judge and their Impact on the Causation of Judgments,” by Oday Tala Mahmood. 4.“Joint Usufruct of Layers and Apartments in the Palestinian Law: A Partner Lease of Common Share,” by Dr. Mahmoud Abd- Almohsen Salameh and Judge Fateh Hamrasheh. 5.“The Role of the Theory of Gross Disparity in protecting the Contractor in the UNIDROIT Principles and Palestinian law: A Comparative Study,” by Dr. Ibrahim Yahya and Dr. Youssef Shandi. 6.“Plea Bargaining Between Reality in Legal Systems and Implementation in Palestine and Qatar: A Comparative and Analytical Study,” by Dr. Mustafa Abdelbaqi and Lama Mrezieq. 7.“The Effect of Fault on Criminal Responsibility: An Analytical Study of the Anglo-Saxon Legal System, by Dr. Eifan. 8.“The Role of Human Rights in Investment Arbitrations: Towards Closer Integration,” by Jassem Al Mulla. 9.“Human Rights of Women: Intersectionality and the CEDAW,” by Buthaina Mohammed Alkuwari. The issue also includes a review of the book “Drafting Legislation in the State of Qatar: Origins, Principles and Standards,” by Mohammed Rashid Alhassan Al-Sulaiti. The editorial board appreciates efforts of all researchers and arbitrators, and we hope that these researches will win the approval of the readers nationally and internationally.
إنهاء عقد العمل وانتهاؤه في قانون العمل الفلسطيني: دراسة مقارنة
Authors: أبو زينة أحمد عبد الوهاب
Published: November 2022

يدور الحديث في هذا البحث عن إنهاء عقد العمل من قبل أيٍّ من طرفيه؛ صاحب العمل، أو العامل؛ وعن حالات انتهاء هذا العقد، سواءٌ أكان محدد المدة أم غير محدد المدة؛ وفقًا لقانون العمل الفلسطيني رقم (7) لسنة 2000، مقارنةً بقانون العمل الأردني رقم (8) لسنة 1996 المعدَّل. وتكمن أهمية ذلك في التمييز بين نوعي العقد من حيث إمكانية انطباق الحالات التي حددها القانون لإنهاء العقد، أو انتهائه عليهما، أو على أحدهما فقط. يوضح البحث أنه يجوز لصاحب العمل إنهاء العقد بنوعيه، من طرف واحد، في حالات محددة، تدور تحديدًا حول صدور مخالفة من العامل، وكذلك حدوث أسباب اقتصادية، أو فنية، تبرّر لصاحب العمل هذا الإنهاء. وبالمقابل يجوز للعامل إنهاء عقد العمل من طرفه؛ إذا صدر من صاحب العمل ما يخالف عقد العمل، أو قانون العمل. يتطرق البحث بعد ذلك إلى الأحكام الخاصة بإنهاء عقد العمل غير محدد المدة، دون العقد محدد المدة، وهي إشعار إنهاء العقد وتعويض الفصل التعسفي. وكذلك إلى حالات انتهاء نوعي العقد، كحالة وفاة العامل، وحالة إغلاق المنشأة. توصل البحث إلى عدة نتائج، أبرزها أن المشرع الفلسطيني في قانون العمل لم يحدد – صراحةً – نوع العقد الذي تنطبق عليه أحكام هذا القانون، فيما يتعلق بحالات إنهاء العقد من طرف واحد، سواء أكان العامل أم صاحب العمل، وكذلك الأمر بالنسبة إلى حالات انتهاء العقد
تطبيق أحكام المسؤولية الإدارية بدون خطأ على قرارات الحكومة الكويتية بحظر التجول بسبب جائحة كورونا
Authors: المحسن فاطمة خالد , النمش منيرة صالح
Published: November 2022

مع غياب النصوص التشريعية الصريحة التي تقرر مسؤولية الإدارة في دولة الكويت دون خطأ؛ فإن التساؤل يثور حول مدى إمكانية استنهاض المسؤولية الإدارية للحكومة الكويتية عن الأضرار الناتجة عن الإجراءات المتخذة من قبلها لمكافحة تفشي جائحة كورونا، وعلى وجه الخصوص إجراءات فرض حظر التجول في البلاد، مع ما قد يترتب على ذلك من إمكانية التعويض عنها. وفي سبيل الإجابة عن التساؤل السابق؛ فإن البحث قد اتبع المنهجية التحليلية؛ حيث بحث أولًا في مدى تحثث أركان المسؤولية الإدارية بلا خطأ في قرارات حظر التجول التي اتخذتها الحكومة الكويتية أثناء تفشي الجائحة، ثم انتقل إلى فحص عدد من الأحكام القضائية الصادرة عن القضاء الإداري الكويتي في هذا المجال في محاولة لتحديد موقفه من المسؤولية الإدارية بدون خطأ. وانتهى البحث إلى أن الساحة القانونية الكويتية – وعلى الرغم من خلوها من النصوص التشريعية الصريحة التي تقرر المسؤولية الإدارية دون خطأ صراحة – إلا أنها مؤهلة لاستقبال الأحكام القضائية التي تقرر هذه المسؤولية تأسيسًا على عدد من المبادئ الدستورية على رأسها مبدأ التضامن الاجتماعي.
Human Rights of Women: Intersectionality and the CEDAW
Authors: Alkuwari Buthaina Mohammed
Published: November 2022

This research aims to track the record of the “Convention on the Elimination of All Forms of Discrimination against Women (CEDAW)” since its entry into force in 1981, to review its texts and the cases brought to it, to know how it considered and dealt with intersectional discrimination against women. This paper evaluates if CEDAW has succeeded or failed to protect women from ‘intersectionality’. However, this discrimination describes compound discrimination against women based on sex, gender, identity, religion, belief, race, ethnicity, color, culture, socioeconomic status, age, class, and/ or origin... etc. The importance of this research is since despite a lot of cases of compound discrimination practiced against women around the world, the text of the Convention has not changed, and its committee, which is composed of experts in this field, did not adopt any ideas about the nature of discrimination. To determine the role of intersectionality, the research first focused on the theory of intersectionality in terms of concept and practice. Secondly, it showed how it affects women’s lives with examples from India, Brazil, Canada, Hungary, and others. Finally, it traced the concept of intersectionality, and how the Convention or its committee dealt with it through its general recommendations. The research found that CEDAW has overlooked the concept of intersectionality in its texts, while its committee addressed it in one of its recommendations in 2010 – noting that such recommendations are limited in scope and efficacy – which adversely impacted women’s rights globally. Therefore, the research recommends that the concept of intersectionality should be fully integrated into the text of the Convention, which will be reflected on the state parties by taking special measures that concretely give advantage to women who have been subjected to a history of discrimination.
ANALYSIS OF OIL PALM PRODUCTION DATA IN PEATLAND OF PT SINAR GUNUNG SAWIT RAYA MANDUAMAS DISTRICT CENTRAL TAPANULI REGENCY
Authors: Lumban Tobing Herdianta , Pratomo Bayu
Published: November 2022

Oil palm is one of the essential vegetable oil-producing plants. Moreover, palm oil is a good trade commodity, and in the future, it is believed that palm oil will not only be able to produce various products such as butter, cooking oil, or soap but also can be a substitute for fuel oil. This study aims to compare crop production in coastal and non-coastal peatlands. This study uses secondary data, including production, rainfall, and fertilization data from the last five years. The results show that Block F2 (on the beach) has the highest production, with a value of 2,442,572 kg/ha. In comparison, Block B2 (non-coastal) has a lesser amount, with a value of 1,818,710 kg/ha.
Educational dictionaries of writers’ language
Authors: Shestakova L. L.
Published: November 2022

The article deals with a range of issues related to such a type of dictionaries as educational dictionaries of writers’ language, or educational author’s dictionaries. The relevance of the research is determined by the factors which researchers define through the concepts of "reading culture crisis", "a decrease in students’ vocabulary size", and others. The material for the analysis was a corpus of educational dictionaries of writers’ language, including editions of the se cond half of the 20th century and the first decades of the 21st century. The research relied on the methodology of lexicographic criticism based on the description, scientific evaluation, and a comparative study of dictionaries. The content and structural analysis of educational author’s dictionaries has shown that the main purpose of such dictionaries (namely to "explain the unclear") determines their strong affinity with defining and not other types of dictionaries. In terms of genre, they are complete explanatory dictionaries, dictionaries of difficult words (i. e. incomplete, similar to glossaries) as well as commentary dictionaries arranged as endnotes or in alphabetical order. At the same time, their word lists, dictionary entries, and description language generally correspond to the principles of educational lexicography although the specificity of the material being described relativises these principles. The study has shown that the general development of educational author’s lexicography started with dictionaries of difficult words which are now usually called dictiona ries of rare, obsolete words and the like and resulted in complete dictionaries of the language of one work. Moreover, an incomplete, as a rule of minuscule volume, educational author’s dictionary is most convenient to obtain information regarding the meaning of an unclear word and its main linguistic characteristics. A complete educational author’s dictionary is valuable when working with a literary text in its entirety. Russianists of different generations have contributed to the development of educational author’s lexicography. N. M. Shansky is one of them. For instance, he proposed a method for compiling line-by-line linguistic dictionary-type commentaries for particular works in the school syllabus. Commentary dictiona ries constitute an integral part of the modern corpus of educational author’s dictionaries.
Caracterización morfo-anatómica de semillas y plántulas de tres especies de Passiflora caerulea, P. mooreana and P. morifolia (Passifloraceae)
Authors: Perez Virginia Melina , Scandaliaris Melina , Arias Claudia Vanina , Perissé Patricia
Published: November 2022

En Córdoba, Argentina, habitan nueve especies nativas de Passiflora de atractivo valor ornamental, frutos comestibles y uso medicinal. El objetivo de este trabajo fue caracterizar la morfo-anatomía de semillas y plántulas de P. caerulea, P. mooreana y P. morifolia. Fueron colectadas semillas de poblaciones naturales, y las plántulas fueron obtenidas mediante pruebas de germinación. Los análisis de las diferentes estructuras se realizaron mediante técnicas convencionales de microscopía estereoscópica, óptica y electrónica de barrido. Las tres especies presentaron semillas completamente rodeadas por un arilo de origen funicular que crece en dirección al extremo calazal, y se diferenciaron por su forma y color. La cubierta seminal se caracterizó por el patrón de ornamentación retículo-foveado, e incluye tres capas tanto en la testa como en el tegmen; exo y mesotesta formadas por células parenquimáticas, y endotesta lignificada en su cara interna. El exotegmen posee macrosclereidas en un patrón sinuoso; meso y endotegmen, células radialmente aplanadas. Las especies analizadas presentaron un embrión espatulado en posición axial, y un endosperma conspicuo ruminado. La germinación es epigea, fanerocotilar y las plántulas presentaron características anatómicas similares; diferenciándose en la morfología de sus nomofilos, nectarios extraflorales, estípulas, ubicación de estomas y presencia de tricomas. Las características morfo-anatómicas descriptas permiten diferenciar a las tres especies en estado de semilla y plántula, y aportan información para completar una detallada caracterización de Passiflora.
Anatomía del leño de Amomyrtella güilli (Myrtaceae, Pimentinae)
Authors: Guantay Maria Eugenia
Published: November 2022

Se describen los caracteres estructurales y ultraestructurales del leño de Amomyrtella güilli, especie monotípica nativa del noroeste argentino perteneciente a la subtribu Pimentinae. Se analizaron muestras recolectadas en las localidades de Los Toldos (Provincia de Salta) y de El Nogalar (Provincia de Tucumán); ambas pertenecientes a las Yungas. La madera se caracteriza por presentar porosidad difusa, con vasos principalmente solitarios. Radios uniseriados y multiseriados de 2-7 células de ancho. Elementos de vaso con apéndices, placa de perforación simple y puntuaciones areoladas. Traqueidas y fibrotraqueidas con puntuaciones areoladas. Parénquima axial apotraqueal difuso o difuso-agregado y parénquima axial paratraqueal  vasicéntrico e incompleto. Este trabajo permitió describir elementos anatómicos del leño de A.güilli de valor sistemático al momento de diferenciar taxones de la misma subtribu.
Activated Carbon Precursors Derived from Jute Fiber: Social, Economic and Environmental Development
Authors: Islam Md. Touhidul
Published: November 2022

Activated carbon fiber (ACF) is undoubtedly one of the most significant carbon nanocomposite materials to consider from the perspective of application in adsorption. Compared to other commercial porous storage materials, it offers many benefits. With a fiber-like shape and a clearly defined porosity structure, activated carbon fiber (ACF) is a potential microporous material. In general, synthetic carbon fiber (CF) can be used to commercially make ACF with the inclusion of an activation procedure. High packing density, outstanding volumetric capacity, rapid adsorption/ desorption, and ease of handling are some of the unique properties of ACF. The production expenses of ACF are made up of fiber processing costs and activation costs, both of which are comparatively more expensive than those of other activated carbons. Recently, researchers have indicated that the manufacturing of ACF from less expensive precursors might be accomplished by preparing activated carbon (AC) from agricultural wastes. In comparison to synthetic ACF, there were fewer details and publicly accessible sources of information about these natural fiber derived ACF. The cost of processing fiber is higher and shaping fiber into the correct shape is challenging. In this study, social and environmental compliance, economic development, advantages of carbon fiber,and applications of carbon fiber are discussed.
In vitro assessment of antibacterial property of camel’s urine against some isolated Salmonella strains
Authors: Nagat A EL Rofaei  , Marwa H Balla  , Elnasri M Mutwali  , Hanan B Elkhiry
Published: November 2022

The study was conducted to assess the antibacterial property of camel’s urine against some Salmonella strains. Twenty camel’s urine samples were collected from different areas (females and males) and examined for their antibacterial activities against the Salmonella strains. Results indicated that all concentrations of urine used (100, 75, 50 and 25%) inhibited the growth of Salmonella strains. After the neutralization of camel’s urine, the results showed the same inhibition effect against Salmonella strains. Results showed that the camel’s urine was more sensitive compared with some antibiotics sensitivity. The minimum Inhibitory Concentration was determined against Salmonella isolates gave the result at low concentration. Results also showed that the camel’s urine incubation for 9 days, in different temperatures showed no bacterial growth up the end of 6th day of incubation. The most microbes detected in this day and in the 9th days were mainly: Staphylococci, Streptococci, Micrococci, Diplococci and few of Bacilli, Actinomycetes and yeasts.
Insight into the mechanism of the Froehde test for morphine
Authors: Sánchez-Viesca Francisco  , Gómez Reina
Published: November 2022

The Froehde reaction for morphine employs a solution of sodium molybdate in concentrated sulphuric acid. This test has been extended to other alkaloids giving different colours. In this communication we present an insight into the reaction with morphine. It has the particularity that it does not invoke the concept of electron back donation since this known point of view reverses the normal polarization of a functional group. This route is based on a novel theoretical finding: the activation of a mixed ester (organic-inorganic) by means of protonation and water loosening. This causes Umpolung (polarity inversion) at ortho position, favouring a nucleophilic attack instead of the electrophilic one due to the original phenol group in morphine. The final part of the route to morphine ortho-quinone goes smooth via a six member concerted mechanism.
Treatment options in synchronous peritoneal metastasis from gastric cancer: A retrospective cohort analysis
Authors: John Spiliotis  , Vasileios Charalampakis  , Dimitrios Farmakis  , Maria Gianniri  , Apostolos Raptis  , Panagiotis Fotiadis  , Faidon Chrysovergidis  , Harris Margari
Published: November 2022

Gastric cancer (GC) is a common malignancy and one of the leading causes of cancer related death. Peritoneal metastases (PM) are not uncommon and then prognosis is poor. Treatment options in these cases are not standardized. The use of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) represents an option in selected patients. We retrospectively analyzed our prospectivey collected peritoneal surface malignancy database and assessed patients with synchronous peritoneal metastases from gastric primary based on peritoneal cancer index (PCI). Over a 16 year period, 600 such patients were identified. They were divided into 5 treatment groups based on their PCI. Surgical morbidity ranged from 5 to 22% and mortality from 1.4 to 3.8%. Overall survival was 7.3 months (range 3.9-14.8). PCI was an independent factor for increased overall survival and the most important factor for treatment decision making. Generally, patients with GC associated PM have poor prognosis. CRS and HIPEC can offer a survival benefit in carefully selected patients. Long-term survival was observed in patients with PCI≤7. Non-surgical approach can be equally effective for more advanced disease and palliative chemotherapy can offer a better quality of life.
Reported estimation techniques for quantification of zaltoprofen: A review
Authors: Thangabalan Boovizhikannan  , Sriyanandini Nagaraja  , Baby Petapalli  , Pavithra Menapati Shankar  , Kavitha Sampath
Published: November 2022

Zaltoprofen is a nonsteroidal anti-inflammatory drug used as an analgesic, antipyretic, and antinflammatory agent. It is a selective COX-2 inhibitor and also inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Zaltoprofen is prescribed for treating pain and inflammatory conditions caused by various disorders such as dental pain, musculoskeletal pain, postoperative pain, and lumbar pain, and frozen shoulder, osteoarthritis and cervico branchial syndrome. There are various analytical methods for estimation of drug. This paper list out the various analytical methods for the drug.
The Effect of Financial Behavior Income and Financial Knowledge on Financial Satisfaction in UMKM in Lamongan City
Authors: Fajriyah Wilda , Handayani Anita
Published: November 2022

The background in this study is behavior of finansial management in Lamongan UMKM tends to be less good. Which is influence by several factors, namely finansial behavior, income, and finansial knowladge. This study aims to test the Financial Behavior, Income, and Financial Knowledge on Financial Satisfaction UMKM in Lamongan City. This study uses quantitative methods. The population in this study amounted to 67, while the sampling used Probability Sampling technique using Non Probability sampling. The reason is because the population is below 100, so all are taken. The samples studied by the researchers were 67 UMKM in Lamongan City. The analysis technique uses instrument testing, classical assumption test, and hypothesis testing. For test tools using the Statistical Package for the Social Sciences (SPSS). The results of this study indicate that financial behavior has a positive and significant effect on financial satisfaction, income has a positive and significant effect on financial satisfaction, and financial knowledge has a positive and significant effect on financial satisfaction.
Analysis of Factor in User Intention to Use the Covid-19 Tracking Application
Authors: Waluyo Retno , Hariguna Taqwa , Wicaksono Agung Purwo
Published: November 2022

Science and technology can be collaborated to create an application that can help to track the contacts of COVID-19 patients. Smartphone-based contact tracing applications have been adopted by more than 50 countries. One of which is in Indonesia. In March 2020, Indonesia launched a mobile application to track the contact of COVID-19 patients namely PeduliLindungi.  During its usage, users find some issues about PeduliLindungi, such as potential data leaks, data misuse, and data inaccuracies. This research is aimed to develop a conceptual model to analyze factors that affect user intentions in using the PeduliLindungi application. The proposed conceptual model is the integration of EUCS, DeLone and McLean that is equipped by the system security variables. There were 288 respondents. The data is processed using SmartPLS 3.0. According to the results of the analysis, the proposed conceptual model has 83.1 percent for its accuracy. User satisfaction and system security give a positive and significant impact on user intentions.  The variables of content, accuracy, format, ease of use, and timeliness give a positive and significant impact on user satisfaction. On the other hand, the system security has no positive and significant impact on user satisfaction. Meanwhile, user satisfaction and system security itself affects the user's intentions in using the PeduliLindungi application.
DDoS Attacks Detection Method Using Feature Importance and Support Vector Machine
Authors: Sanmorino Ahmad , Gustriansyah Rendra , Alie Juhaini
Published: November 2022

In this study, the author wants to prove the combination of feature importance and support vector machine relevant to detecting distributed denial-of-service attacks. A distributed denial-of-service attack is a very dangerous type of attack because it causes enormous losses to the victim server. The study begins with determining network traffic features, followed by collecting datasets. The author uses 1000 randomly selected network traffic datasets for the purposes of feature selection and modeling. In the next stage, feature importance is used to select relevant features as modeling inputs based on support vector machine algorithms. The modeling results were evaluated using a confusion matrix table. Based on the evaluation using the confusion matrix, the score for the recall is 93 percent, precision is 95 percent, and accuracy is 92 percent. The author also compares the proposed method to several other methods. The comparison results show the performance of the proposed method is at a fairly good level in detecting distributed denial-of-service attacks. We realized this result was influenced by many factors, so further studies are needed in the future.
Pattern Detection of Economic and Pandemic Vulnerability Index in Indonesia Using Bi-Cluster Analysis
Authors: Ningsih Wiwik Andriyani Lestari , Sumertajaya I Made , Saefuddin Asep
Published: November 2022

Bi-clustering is a clustering development that aims to group data simultaneously from two directions. The Iterative Signature Algorithm (ISA) is one of the bi-clustering algorithms that work iteratively to find the most correlated bi-cluster. Detecting economic and pandemic vulnerability using bi-cluster analysis is essential to get spatial patterns and an overview of Indonesia's economic and pandemic vulnerability characteristics. Bi-clustering using ISA requires setting the row and column threshold to form seventy combinations of thresholds. The best is chosen based on the average value of mean square residue to volume ratios. In addition, the similarity of the best bi-cluster with the other is also seen based on the Liu and Wang index values. The -1.0 row and -1.0 column threshold combinations were selected and produced the best bi-cluster with the smallest average value of mean square residue to volume ratios (0.00141). Based on Liu and Wang index values, it has more than 95% similarity with the combination of -1.0 row and -0.9 column thresholds and the -0.9 row and -1.0 column thresholds. These selected threshold combinations produce three bi-clusters with five types of spatial patterns and different characteristics because of the overlap between these three bi-clusters.
Francesco Ferrara, il primo degli economisti cafoscarini
Authors: Faucci Riccardo
Published: November 2022

The paper presents the important personality of the great Italian economist Francesco Ferrara who has been the first Director of the new School of Commerce founded in Venice in 1868. The paper is divided into two parts: the first part presents the main features of Francesco Ferrara as an economist, showing how he was clearly a supporter of a free-market oriented vision of the economic analysis and of the economic policy, not liking at all a vision of the economic analysis separated from the political implications, but definitely favouring a political economy vision. He was a sharp opponent of socialism, although admiring the logical power of Marx’s thought, but not Marxian ideas. But he was also an opponent of intermediate visions leading to mediations in the field of economic policy. His rather radical positions led him to resign from the role of minister of Finance. In the second part, the paper shows how Ferrara accepted Luigi Luzzatti’s proposal to be appointed as director of the new School of Commerce of Ca’ Foscari in summer 1868; the paper shows how the relations between Ferrara and Luzzatti were characterised by polemical moments, both because of the lines followed by Ferrara in appointing the professors of the new school and because of the openness shown by Luzzatti, and not liked at all by Ferrara, towards policies showing a favourable attitude towards social interventions. Eventually the disagreements were solved. Finally, the paper shows how Ferrara succeeded in appointing at Ca’ Foscari some of the most important Italian economists of his time, such as Maffeo Pantaleoni.
Das Bild der südasiatischen Architektur in den Texten von William Hodges
Authors: Hartig Anne
Published: November 2022

Im Zusammenhang mit der Kolonialisierung beginnen Europäer sich für die Kunstund Architekturgeschichte Südasiens zu interessieren und diese systematisch zu studieren. Zu den frühesten Berichten über die südasiatische Architektur gehört A Dissertation on the Prototypes of Architecture, Hindoo, Moorish, and Gothic (1787) des britischen Landschaftsmalers William Hodges (1744–1797). Die kurze Abhandlung setzt sich von früheren deskriptiven Berichten ab, da Hodges versucht, seine Beobachtungen zur Architektur Südasiens in einen größeren architekturtheoretischen Rahmen zu stellen. Ins Französische und Deutsche übersetzt, verbreitet sich Hodges’ Abhandlung über nicht-europäische Architektur in Europa und trägt dazu bei, das Bild Südasiens nicht nur in England, sondern auch in Deutschland zu prägen. Der Artikel betrachtet Hodges’ Dissertation als einflussreichen Vorläufer der systematischeren und bekannteren Studien des 19. Jahrhunderts. Indem er diesen Schlüsseltext und Hodges Argumentation kritisch analysiert, gibt der Artikel nicht nur Einblicke in einen frühen Moment der Lesart südasiatischer Architektur, sondern arbeitet auch ihre Rolle bei der Schaffung eines Bildes der südasiatischen Architektur heraus.
»Ich kann das nicht verstehen, dass die Leute dann manchmal wegschauen«
Authors: Staib Lucia , Heusner Julia , Leonhardt Nico , Schuppener Saskia
Published: November 2022

Der vorliegende Beitrag stellt den Versuch dar, die Sichtweisen und Erfahrungen von Menschen mit Behinderungserfahrungen zu Beginn der Coronapandemie aufzuzeigen und diese mit einer (kritischen) Reflexion bestehender medialer und theoretischer Diskurse zu verknüpfen. Hierzu erfolgt eine kritische Auseinandersetzung mit dem Konstrukt der ›Risikogruppe‹ und dem Konzept der Solidarität. Auf der Basis einer Pluralisierung wird für ein Konzept von Solidarität/solidarischem Handeln plädiert, welches grundsätzlich differenzbejahend ist und Exklusionsmechanismen sowie Ausschlüsse nicht reproduziert, sondern zum Ausgangspunkt von Kritik macht. So können mit Blick auf Menschen mit Behinderungserfahrungen ableistische Strukturen und Kulturen identifiziert und langfristig verändert werden.
Quality in TESOL and Teacher Education. Martínez Agudo, Juan de Dios (Ed.) (2020). Routledge, Print ISBN: 9780367187873, 0367187876, eText ISBN: 9780429582349, 042958234X
Authors: Madrid Fernández Daniel
Published: November 2022

Concern for the quality of educational systems has been prevalent worldwide. For many years, governments have strived to improve their educational systems and have passed successive laws with this aim. Frequently, the quality of education has been conceived as a philosophical and instrumental tool that intervenes in social transformation at a global level, and it has been given such importance that, in recent years, it has become the key term of the educational legislation of most countries (Madrid & Julius, 2017). The concept of quality has been understood in many ways. In the educational field, a quality education focuses on the entire person: on socio-affective and personal dimensions, as well as on the cognitive development of students, regardless of their gender, race, ethnicity, socioeconomic status or geographic location.
Poetry for EFL: Exploring Change in Undergraduate Students’ Perceptions
Authors: Férez Mora Pedro Antonio , Coyle Yvette
Published: November 2022

This study explores undergraduate students’ beliefs concerning the potential of poetry as a resource for EFL before and after the administration of a lesson plan based on a poem. To this end, 132 students were surveyed to obtain both quantitative and qualitative data on the linguistic, motivational and intercultural benefits which literature has been said to contribute to EFL. The results show that, in the pretest, students believe poetry-based English lessons to be more useful for developing linguistic knowledge than for intercultural or motivational gains. In the post-test, however, students assign significantly more importance to the motivational and intercultural components. This change seems to highlight the overly instrumental nature of the instruction students received during their schooling in EFL.
Electoral Reforms in Russia’s Regions: An Equilibrium between Disproportionality and Legitimacy
Authors: Turovsky Rostislav , Funk Karina
Published: November 2022

This study examines the dynamics of electoral reforms in the constituent entities of the Russian Federation and their influence on the disproportionality of parliamentary representation since the electoral system experienced major changes in 2003. We suggest that some characteristics of the electoral system may be highly instrumental in ensuring and maintaining United Russia’s influence in legislative bodies. This makes it possible to classify them as forms of institutional manipulation typical of electoral authoritarianism. Based on the statistical description and regression analysis, the study demonstrates the impact of some elements of electoral reforms on disproportionality during the periods at issue. At the same time, we can identify the methods of cementing the dominant party’s hold on power that the authorities find the most effective. In this regard, we make the conclusion that certain elements of the electoral system function as a balanced mechanism, which is evidenced by how they have been used during the different periods. Additionally, the study analyses the impact of disproportionality on electoral behavior, with the hypothesis about its negative influence on the electoral turnout being supported. Yet we regard the lower turnout as a consequence of the voting behavior of both the opposition’s supporters and loyalists. Finally, the electoral reforms in Russia seem to have put limits on disproportionality of parliamentary representation due to the issue of legitimacy.
Penerapan Metode Electre Pada Studi Kasus Pemilihan Sepeda Motor Matic
Authors: Suyibah Suyibah , Kuzairi Kuzairi
Published: November 2022

The need for transportation is an absolute thing in today's life, almost all people today already have a means of transportation, most of which are motorbikes. With the development of today's technology, motorcycles have made some progress, such as in terms of transmission. For example, on automatic motorbikes whose transmissions are produced manually, there are many variations of automatic motorbikes such as: Beat, Vario, Scoopi and Space. In choosing an automatic motorcycle, of course, consumers want to get the best and right choice. Almost all consumers want automatic motorcycles that are affordable, fuel efficient and comfortable to use. Therefore, we need a decision support system that can assist consumers in choosing the best automatic motorcycle according to consumer desires. This decision support system uses the electre method as a process in determining the best motorbike so that the results are that vario and scoopi dominate more than beat and space.
Agglomerative Hierarchy Clustering Pada Penentuan Kelompok Kabupaten/Kota di Jawa Timur Berdasarkan Indikator Pendidikan
Authors: Dewi Ardiana Fatma , Ahadiyah Kurnia
Published: November 2022

Salah satu cara agar dapat meningkatkan kondisi pendidikan di setiap kabupaten/kota di Jawa Timur adalah dengan menggunakan analisis pengelompokan sesuai dengan karakteristik pendidikannya. Analisis Klaster merupakan analisis yang termasuk ke dalam golongan analisis multivariat yang bertujuan untuk mengelompokkan  objek berdasarkan karakteristik yang dimilikinya. Penelitian ini menggunakan analisis klaster tipe agglomerative dengan lima metode. Analisis klaster ini disebut dengan “agglomerative hierarchy clustering”. Tujuan penelitian ini adalah membandingkan metode analisis klaster herarki tersebut dengan mencari model terbaik melalui pencarian nilai koefisien korelasi cophenetic terbesar. Data yang digunakan pada penelitian ini merupakan data sekunder yang diperoleh dari Badan Pusat Statistik (BPS) Jawa Timur dan Kementerian Pendidikan Republik Indonesia. Pada pengelompokan Kabupaten/Kota di Provinsi Jawa Timur berdasarkan indikator pendidikan dengan menggunakan metode Agglomerative Hierarchical Clustering dihasilkan bahwa algoritma optimal yang digunakan yaitu pada algoritma average linkage dengan nilai korelasi cophenetic yang diperoleh sebesar 0,807. Berdasarkan indikator pendidikan dari 38 Kabupaten/Kota di Provinsi Jawa Timur terbagi menjadi dua cluster dimana pada cluster pertama beranggotakan 3 Kabupaten/Kota dan cluster kedua 35 Kabupaten Kota.

 Keywords: Agglomerative, Clustering, Hierarchical, cophenetic