bluuebunny/crossref_metadata_2025 huggingface dataset:
Nonlinear response in diffusive systems
Authors: Delacrétaz Luca V. , Mishra Ruchira
Published: February 2024

Nonintegrable systems thermalize, leading to the emergence of fluctuating hydrodynamics. Typically, this hydrodynamics is diffusive. We use the effective field theory (EFT) of diffusion to compute higher-point functions of conserved densities. We uncover a simple scaling behavior of correlators at late times, and, focusing on three and four-point functions, derive the asymptotically exact universal scaling functions that characterize nonlinear response in diffusive systems. This allows for precision tests of thermalization beyond linear response in quantum and classical many-body systems. We confirm our predictions in a classical lattice gas.
Physiological quality of seeds of Mimosa bimucronata (DC) O. KTZE. subjected to different types of drying
Authors: Melo Luan Danilo Ferreira de Andrade , Junior João Luciano de Andrade Melo , Berto Thaíse dos Santos , Paes Reinaldo de Alencar , Costa Jaqueline Figueredo de Oliveira , Oliveira Vanuze Costa de , Silva Ivanildo Claudino da , Chaves Lívia Francyne Gomes , Duarte Adriana Guimarães , Silva José Antonio Costa , Assis Wesley Oliveira de
Published: February 2024

Despite its potential, to date, work has not been carried out to identify the ideal drying conditions for Mimosa bimucronata (DC) O. Kuntze. Considering the scarcity of information on the drying process of this species, this work was with the objective of evaluating the sensitivity to desiccation by means of drying on activated silica gel (fast) and under laboratory conditions (slow). Rapid drying with silica was performed. For slow drying, the seeds were placed in plastic containers without lids, both at room temperature. Every hour, the seeds were weighed until reaching the pre-established points (30, 25, 20, 15 and 10%). The variables analyzed were: water content, first germination count, germination, germination speed index, dry mass and seedling length. The seeds of M. bimucronata (DC) show orthodox behavior, withstanding desiccation at levels below 15%. The desiccation of seeds at very low levels impairs the formation of seedlings, preventing their normal development.
Performance of soybean cultivated following intercropped corn under varying nitrogen levels
Authors: Sapucay Moryb Jorge Lima da Costa , Coelho Antonio Eduardo , Locatelli Jorge Luiz , Bratti Felipe , Debiasi Henrique , Santos Julio Cezar Franchini dos , Junior Alvadi Antonio Balbinot , Zucareli Claudemir
Published: February 2024

The intercropping of second-crop corn with ruzigrass or showy rattlebox associated with an increase in the nitrogen (N) rate can improve the performance of soybean in succession. This study aimed to evaluate the soybean performance in succession to second-crop corn cultivated under N application rates, with or without intercropping with ruzigrass (Urochloa ruziziensis) or showy rattlebox (Crotalaria spectabilis). The experimental design was a complete randomized block design with a split-plot scheme with four replicates. The plots were composed of the cultivation of either sole corn (AG 9010 PRO) or corn intercropped with ruzigrass or showy rattlebox, and the subplots consisted of different N topdressing rates (0, 60, 120, 180, and 240 kg ha-1). Soybean (BRS 1003 IPRO) was grown in succession to corn under a no-tillage system (NTS). The evaluated variables were growth and yield. The increase in N rate in second-crop corn, with or without intercropping with ruzigrass or showy rattlebox, increased the growth and yield of soybean in succession under NTS. Second-crop corn intercropped with ruzigrass provided a greater amount of straw under NTS than sole corn or intercropped with showy rattlebox. However, intercropped systems did not influence the growth and yield of soybean grown in succession. Therefore, the corn intercropped with ruzigrass promotes the sustainability of NTS and the N fertilization in second-crop corn, which subsequently improves soybeans performance
A field study on the combined use of pre-emergence herbicide and Clearfield® technology for ryegrass management in wheat crops
Authors: Freitas Lariane Fontana de , Fruet Diogo Luiz , Schelter Mayra Luiza , Souza Marissa Prá de , Guerra Naiara , Neto Antonio Mendes de Oliveira
Published: February 2024

Weed interference in wheat crops are known to cause productivity losses. The objective of this work was to evaluate pre-emergence herbicide application efficiency combined with Clearfield® technology (CL) in ryegrass (Lolium multiflorum) management in wheat crops. A field experiment was conducted from July 2020 to December 2021 using randomized block design in a 2×5 factorial arrangement with four replications. Treatments consisted of combinations of pre-emergence herbicide application - without and with pendimethalin at 1365 g a.i. ha-1 (in 2020 crop season) or without and with pyroxasulfone at 125 g a.i. ha-1 (in 2021 crop season) and post-emergence herbicide application - without application; imazamox at 49, 70, and 91 g a.i. ha-1, or pyroxsulam at 18 g a.i. ha-1. Wheat cultivars used were TBIO Capricho CL® and TBIO Ello CL®. The following characteristics were evaluated: phytotoxicity, ryegrass control, plant height, number of spikes m-2, mean spike weight, 100-grain weight, and grain yield. Treatments phytotoxicity did not exceed 5%, being visible only at 7 DAA, from 14 DAA no injury was observed. The combined application of pre-emergence herbicides pendimethalin or pyroxasulfone with post-emergence herbicides imazamox or pyroxsulam provided superior control of ryegrass than the isolated applications. This management resulted in ryegrass control ranging from 88.8% to 100% in 2020 and from 82.3% to 100% in 2021. In general, grain yield was also higher in treatments with combined pre- and post-emergence applications. The pre-emergence herbicide application in combination with CL technology was effective in managing ryegrass, preventing weed interference, and ensuring the productive potential of wheat crops
Elaboración de objetos educativo-culturales desde la postmodernidad literaria de Paul Auster
Authors: Fajardo Salinas José Manuel
Published: February 2024

Tomando como contexto amplio la noción del “espacio cultural latinoamericano”, esta reflexión busca descubrir algunas condiciones de posibilidad básicas para que, quien tenga la iniciativa de confeccionar objetos educativo-culturales contemporáneos, cuente con algunas claves de sentido que orienten su labor, tanto para la concepción, el diseño, la promoción y, sobre todo, la efectividad de su tentativa. Este objetivo lleva a una revisión hermenéutica, en clave cultural, de una selección de novelas del escritor norteamericano Paul Auster. La hipótesis que guía el recorrido por las tramas y los personajes de dichas obras es considerar que su configuración y dinamismo apuntan a lo postmoderno, considerado como lo distintivo de la época cultural contemporánea. De este modo, y luego de analizar las obras del autor, donde se recogen rasgos culturales tendientes a lo postmoderno, se reflexiona con algunos teóricos sobre conceptos que ayuden a configurar una síntesis inteligente de lo previo. Gracias a ello, se concibe que ante la descolocación del metarrelato moderno, la postmodernidad cultiva una concepción renovada de emancipación que tiende a manifestarse en la estética artística con lógica de post-autonomía. Merced a estas connotaciones de sentido, es posible sugerir ciertas precondiciones de acción para el apoyo de la creación educativo-cultural contemporánea. Ello es significativo para el movimiento intercultural, pues en la búsqueda de una convivencia plural en un mundo común, es favorable contar con orientaciones que ayudan a identificar mejor a los sujetos culturales contemporáneos y así ofrecerles su propuesta desde un lenguaje pertinente y asequible a su sensibilidad.
Problems with the diagnosis of haemotropic mycoplasma - like infection in the European wisent (Bison bonasus)
Authors: KALICKI MIROSŁAW
Published: February 2024

A veterinarian treating wildlife must sometimes provide assistance to a sick animal based on incomplete data. Animals of special biological value are not the same as livestock. Some procedures routinely performed on domestic animals require pharmacological restraint in the veterinary service of large and dangerous wild animals. Therefore, such procedures are performed only in situations of absolute necessity. Such a situation took place in the Gdańsk zoo when a young European wisent (Bison bonasus) showed symptoms of haemotropic mycoplasma infection. Hemotropic mycoplasmas cause intravascular infection by attaching to red blood cells and triggering an immune response leading to elimination of the affected cells. This process can result in the development of hemolytic anemia. The case of suspected hemotropic mycoplasmosis in a European wisent described in this paper concerns an almost 2-year-old female, who lost her mother at the age of 11 months and from that time was the lowest in the hierarchy in the group of 10 wisents exposed at the zoo. The disease was manifested by emaciation, marked weakness, protrusion of the third eyelid and severe pallor of the mucous membranes. The sick animal was immobilized. Collected blood showed significant anemia (RBC 1.51 T/l, Ht 0.08 l/l), and microscopic imaging showed characteristic cells adjacent to erythrocytes suggestive of hemotropic mycoplasma infection. The animal was treated with a long-acting oxytetracycline administered three times a week, for 6 weeks. At the end of the 6-week treatment the wisent was immobilized and it was found that the nutritional status of the animal improved, the third eyelid returned to its physiological state and the pallor of the mucous membranes disappeared completely. Examination proved that the red blood cells and hematocrit reached a state that could be interpreted as physiological (RBC 4.89 T/l, Ht 0.26 l/l0, no microscopic changes of RBCs. Unfortunately, the available laboratory methods did not confirm the presence of mycoplasma genetic material. However, the efficacy of the used antibiotic therapy could be a confirmation that the disease was caused by hemotropic mycoplasmas.
Foreign Experience in Strategizing Accelerated Socio-Economic Development and Options for Its Application in Russia
Authors: Aganbegyan Abel
Published: February 2024

Socio-economic development is a vital strategy for the Russian Federation. In the 33 years after the collapse of the Soviet Union, its gross domestic product (GDP) has increased by approximately 20 %. The average GDP in EU countries has increased by halve for the same period. The US GDP has doubled while some post-socialist European countries have demonstrated a 2.5-time increase, not to mention developing countries (3-5 times) and China (12.7 times). Between 2013 and 2022, Russia’s GDP per capita stayed the same, probably because of the Crimea population. The gross fixed capital formations decreased slightly, and the volume of retail trade turnover and real income of the population went down more sharply. Compared to the Soviet period, Russia has been losing in all indicators of international ratings. Life expectancy, which is one of the main social indicators, keeps decreasing with every decade. In fact, it has been seven years since Russia’s population started to decline. Part one of this article examines the outstanding experience of China, Japan, and South Korea, which have transited from seemingly hopeless backwardness to stable economic and social growth in 30-40 years. However, these countries are so unique in their cultural and historical development that their experience cannot be applied to Russia directly. Part two examines the phenomena of Reaganomics in the USA and Thatcherism in the UK, which allowed each of these countries to overcome a decade of stagnation and crisis to resume socio-economic development based on science, technology, and innovations. Part three examines some cases of large countries that have demonstrated high growth rates over the past ten years despite complex situations in the global economy. The objective was to define the specific strategies these countries appealed to in order to combat the existing negative trends in economic development. The conclusion sums up the useful experience Russia can draw from the abovementioned cases. The author introduces a strategy for accelerated and sustainable socio-economic development of Russia though 2035.
Strategizing Economy as a Pr ospective Major at Flagship University of Kuzbass
Authors: Leukhova Maria , Alabina Tatiana , Starodubtseva Alina
Published: February 2024

Strategizing is a relevant area of professional activity that requires new specialists capable of innovative strategic thinking. As a result, the Kemerovo State University has launched a Master’s degree program in Economic and Financial Strategy. It provides high-quality economic education based on the current social demands and advanced trends. Its graduates undergo an in-depth training in economic strategy with prospects of becoming leaders in various aspects of the regional industry. Designed as an analogue of the world-class Master’s program at the Lomonosov Moscow State University, the curriculum has a certain regional specificity. It is based on the local needs in the implementation of the Strategy for the Socio-Economic Development of the Kemerovo Region through 2035. The Strategy with its long-term prospects was developed by the scientific school of strategizing. The school is headed by Professor Vladimir L. Kvint, Doctor of Economics, Foreign Member of the Russian Academy of Sciences, Head of the Center for Strategic Research, Institute for Mathematical Research of Complex Systems, Lomonosov Moscow State University.
Transforming the Strategic Communications System in the Light Industry and Fashion
Authors: Khvorostyanaya Anna
Published: February 2024

The fashion industry has to update collections extremely fast, which leads to resource depletion in the absence of demand. Moreover, environmentally-aware consumers tend to associate this accelerated production cycle with environmental pollution. As a result, the growing public interest in green materials and lean manufacturing increases the popularity of brands that are associated with sustainable business practices. The relevance of the topic is due to the fact that the strategic communications system is also a subject to qualitative changes brought about by new trends and patterns. If a fashion enterprise changes its principles, philosophy, ideology, and strategic priorities in the context of environmental transformations, customers should be made aware of these changes. Strategic communications and their transformations in the TFC industry remain largely understudied. The author identified the current working tools of the strategic communications system that could provide effective long-term development in the fashion industry. The research relied on the theory and methodology of strategizing developed by Professor V.L. Kvint, Dr.Sc.(Econ.), Foreign Member of the Russian Academy of Sciences. Such standard methods as analysis, synthesis, generalization, abstraction, and benchmarking made it possible to reveal the key strategic trends and patterns that shape the contemporary strategic principles of entrepreneurship in the TFC industry. The resulting updated system of strategic communications is effective in bringing across new values to fashion consumers.
On the hydraulic performance of the inclined drops: the effect of downstream macro-roughness elements
Authors: Kalateh Farhoud , Aminvash Ehsan , Daneshfaraz Rasoul
Published: February 2024

The main goal of the present study is to investigate the effects of macro-roughnesses downstream of the inclined drop through numerical models. Due to the vital importance of geometrical properties of the macro-roughnesses in the hydraulic performance and efficient energy dissipation downstream of inclined drops, two different geometries of macro-roughnesses, i.e., semi-circular and triangular geometries, have been investigated using the Flow-3D model. Numerical simulation showed that with the flow rate increase and relative critical depth, the flow energy consumption has decreased. Also, relative energy dissipation increases with the increase in height and slope angle, so that this amount of increase in energy loss compared to the smooth bed in semi-circular and triangular elements is 86.39 and 76.80%, respectively, in the inclined drop with a height of 15 cm, and 86.99 and 65.78% in the drop with a height of 20 cm. The Froude number downstream on the uneven bed has been dramatically reduced, so this amount of reduction has been approximately 47 and 54% compared to the control condition. The relative depth of the downstream has also increased due to the turbulence of the flow on the uneven bed with the increase in the flow rate.
Removal of pollutants from landfill leachate by adsorption with nano zero-valent iron particles: adsorption isotherms and kinetic studies
Authors: Göçer Serdar , Zaimoğlu Binnaz Zeynep , Cırık Kevser
Published: February 2024

Nano zero-valent iron (nZVI) is an effective adsorbent for removing various organic and inorganic contaminants. In this study, nZVI particles, synthesized in our previous work, were used for landfill leachate pretreatment. The adsorption performance was tested at various adsorbent concentrations (50–500 mg Fe0/L), pH (3–8), and contact times (15–330 min). Chemical oxygen demand, dissolved organic carbon (DOC), nitrate (NO3-), and ammonium (NH4+) removal efficiency were approximately 75%, 60, 57, and 33%, respectively. The obtained data were fitted well by the Langmuir isotherm and adsorption kinetics of pseudo-second-order equations (R2 > 0.9). The adsorption capacities were found to be 29.62, 21.01, and 3.12 mg/g for DOC, NH4+, and NO3−, respectively, at Fe0 concentration of 50 mg Fe0/L, pH of 8, and contact time of 120 min, which was determined as the effective operational conditions in this work. The obtained removal levels were higher compared to the conventional activated carbon adsorption (72.3%). Results suggest that nZVI has the potential to create effective adsorption relevant to landfill leachate pretreatment, thereby providing more efficient biological treatment by decreasing important pollutants before biological treatment.
Regenerative Medicine and Nanotechnology Approaches against Cardiovascular Diseases: Recent Advances and Future Prospective
Authors: Sajjad Muhammad Waseem , Muzamil Fatima , Sabir Maida , Ashfaq Usman Ali
Published: February 2024

Regenerative medicine refers to medical research focusing on repairing, replacing, or
regenerating damaged or diseased tissues or organs. Cardiovascular disease (CVDs) is a significant
health issue globally and is the leading cause of death in many countries. According to the
Centers for Disease Control and Prevention (CDC), one person dies every 34 seconds in the United
States from cardiovascular diseases, and according to a World Health Organization (WHO) report,
cardiovascular diseases are the leading cause of death globally, taking an estimated 17.9 million
lives each year. Many conventional treatments are available using different drugs for cardiovascular
diseases, but these treatments are inadequate. Stem cells and nanotechnology are promising
research areas for regenerative medicine treating CVDs. Regenerative medicines are a revolutionary
strategy for advancing and successfully treating various diseases, intending to control cardiovascular
disorders. This review is a comprehensive study of different treatment methods for
cardiovascular diseases using different types of biomaterials as regenerative medicines, the importance
of different stem cells in therapeutics, the expanded role of nanotechnology in treatment, the
administration of several types of stem cells, their tracking, imaging, and the final observation of
clinical trials on many different levels as well as it aims to keep readers up to pace on emerging
therapeutic applications of some specific organs and disorders that may improve from regenerative
medicine shortly.
Kombinasi Pupuk Nitrogen dan Pupuk Organik Pada Pertumbuhan dan Hasil Kembang Kol (Brassica oleracea Var. Botrytis L)
Authors: Ichsan Janis Majida , Barunawati Nunun
Published: February 2024

Kembang kol (Brassica oleracea Var. Botrytis L.) adalah salah satu komoditas penting dan banyak dibudidayakan di Indonesia. Tanaman kembang kol banyak digunakan masyarakat sebagai bahan pangan untuk memenuhi kebutuhan gizi. Jumlah produksi kembang kol di Indonesia pada tahun 2020 yaitu 204 ribu ton dengan rata-rata hasil 13 ton ha-1, dan mengalami penurunan produksi pada tahun 2021 dengan total produksi 203 ribu ton dengan rata-rata hasil 12,14 ton ha-1. Produksi dari kembang kol dapat terus ditingkatkan salah satunya dengan cara kegiatan pemupukan. Pupuk dalam praktik budidaya kembang kol tergolong menjadi dua jenis yaitu pupuk anorganik dan pupuk organik. Pemberian pupuk anorganik saja belum dapat meningkatkan produktivitas kembang kol secara berkelanjutan sehingga diperlukan kombinasi penambahan pupuk organik dan anorganik yaitu pupuk nitrogen dan pupuk kandang yang mengandung berbagai bahan organik yang dibutuhkan tanaman dan meningkatkan kesuburan tanah secara berkelanjutan. Penelitian ini dilaksanakan pada bulan Januari 2023 – April 2023 di Kebun Percobaan Fakultas Pertanian Universitas Brawijaya. Penelitian ini menggunakan rancangan acak kelompok (RAK) yang terdiri dari 9 perlakuan dan 3 ulangan. Hasil penelitian menunjukkan bahwa kombinasi pupuk urea dan pupuk kandang mampu meningkatkan pertumbuhan dan hasil tanaman kembang kol. Dosis pupuk urea 300 kg ha-1 + 30 ton ha-1 pupuk kandang mampu meningkatkan tinggi tanaman, jumlah daun, waktu berbunga yang lebih cepat, diameter bunga dan bobot panen kembang kol dibandingkan dengan perlakuan yang lain.
Respon Lima Varietas Kacang Panjang (Vigna Sinensis L.) Terhadap Perbedaan Dosis Pupuk Nitrobakter Pada Fase Vegetatif dan Generatif
Authors: Putri Roudhotul Rizki Novita , Kuswanto Kuswanto
Published: February 2024

Kacang Panjang (Vigna sinensis L.) merupakan tanaman hortikultura yang memiliki nilai ekonomi tinggi di Indonesia. Rendahnya produktivitas kacang panjang dapat disebakan adanya beberapa kendala, salah satunya ialah cara budidaya yang dilakukan petani. Penggunaan pupuk organik jarang dilakukan oleh petani dikarenakan pupuk organik tidak memiliki kandungan unsur hara tinggi seperti pupuk anorganik, namun pupuk organik memiliki manfaat lain yaitu dapat memperbaiki sifat fisik tanah serta dapat meningkatkan metabolisme pada fase vegetaif dan fase generatif tanaman. Tujuan penelitian ini untuk mempelajari respon lima varietas tanaman kacang panjang terhadap perbedaan dosis pupuk nitrobakter pada fase vegetatif dan fase generatif. Penelitian dilaksanakan bulan Februari sampai Mei 2023 di Kebun Percobaan IP2TP Jambegede, berlokasi di Desa Kemiri, Kecamatan Kepanjen, Kabupaten Malang, Jawa Timur. Penelitian disusun menggunakan RPT (Rancangan Petak Terbagi). Percobaan terdiri dari dua faktor dan di ulang sebanyak 3 kali. Faktor pertama yaitu dosis pupuk sebagai petak utama dan faktor kedua varietas sebagai anak petak. Hasil penelitian menunjukkan bahwa perbedaan varietas memberikan respon yang berbeda terhadap berbagai dosis pupuk nitrobakter dan ditunjukkan pada variabel jumlah daun, jumlah bunga per tanaman, umur terbentuk polong, jumlah polong per tanaman, bobot 100 biji, dan potensi hasil per varietas. Varietas Brawijaya 1 memberikani pertumbuhan dan hasil yang lebih baik dibandingkan dengan keempat varietas yang lain.
Simultaneous Cardiopulmonary Exercise Testing and Echocardiography for Investigation of Cardiopulmonary Dysfunction in Outpatients: Protocol for a Scoping Review
Authors: Gerhardy Benjamin , Sivapathan Shanthosh , Orde Sam , Morgan Lucy
Published: February 2024

Background

Cardiopulmonary dysfunction is a complex process with a broad range of etiologies. Investigations performed either at rest or those that only assess the function of a single organ (heart or lungs) are often insufficient. A simultaneous cardiopulmonary exercise test with stress echocardiography is a new approach to assessing cardiopulmonary dysfunction as it provides anatomical and functional imaging simultaneously while under increasing stress. To date, the application of cardiopulmonary exercise test-stress echocardiography (CPET-SE) has been broad and without structure, and its effect on patient outcomes is unclear.

Objective

The objective of this scoping review is to explore and analyze the evidence regarding the role of simultaneous CPET-SE in investigating cardiopulmonary dysfunction in outpatients. It will include any published study in which adult (older than or equal to 18 years of age) patients have completed a CPET-SE for the investigation of cardiopulmonary dysfunction.

Methods

This review will follow the Arksey and O’Malley framework, supported by the Joanna Briggs Institute methodology for scoping reviews. It will use the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) checklist. Data sources will include MEDLINE, Scopus, Embase, and Cochrane (including reviews, trials, and protocols) electronic databases, with no date range defined. The search will be limited to the English language with no restrictions regarding pathology. Secondary references of the included sources will also be assessed by a hand search for suitability. A 2-person title-abstract screen and data charting process will be used. Independent experts will be used for consultation including an academic librarian and clinicians. The Covidence software will be used for article screening.

Results

This scoping review will provide a unified and detailed description of the applications of CPET-SE in investigating cardiopulmonary dysfunction. This will provide a platform for future research harnessing this investigatory method. The results will be presented in both tabular and graphical formats to ensure clarity. The results of this scoping review will be submitted to a relevant peer-reviewed academic journal for publication.

Conclusions

The CPET-SE is a powerful tool for investigating cardiopulmonary dysfunction but remains in its infancy with a patchwork approach to indications, data reporting, and interpretation. This scoping review will unify the literature and provide a platform for future researchers and the development of a comprehensive application guideline.

Trial Registration

Open Science Framework; https://osf.io/98r3e

International Registered Report Identifier (IRRID)

PRR1-10.2196/52076
A Digital Intervention to Improve Skin Self-Examination Among Survivors of Melanoma: Protocol for a Type-1 Hybrid Effectiveness-Implementation Randomized Trial
Authors: Manne Sharon , Heckman Carolyn J , Frederick Sara , Schaefer Alexis A , Studts Christina R , Khavjou Olga , Honeycutt Amanda , Berger Adam , Liu Hao
Published: February 2024

Background

Although melanoma survival rates have improved in recent years, survivors remain at risk of recurrence, second primary cancers, and keratinocyte carcinomas. The National Comprehensive Cancer Network recommends skin examinations by a physician every 3 to 12 months. Regular thorough skin self-examinations (SSEs) are recommended for survivors of melanoma to promote the detection of earlier-stage, thinner melanomas, which are associated with improved survival and lower treatment costs. Despite their importance, less than a quarter of survivors of melanoma engage in SSEs.

Objective

Previously, our team developed and evaluated a web-based, fully automated intervention called mySmartSkin (MSS) that successfully improved SSE among survivors of melanoma. Enhancements were proposed to improve engagement with and outcomes of MSS. The purpose of this paper is to describe the rationale and methodology for a type-1 hybrid effectiveness-implementation randomized trial evaluating the enhanced MSS versus control and exploring implementation outcomes and contextual factors.

Methods

This study will recruit from state cancer registries and social media 300 individuals diagnosed with cutaneous malignant melanoma between 3 months and 5 years after surgery who are currently cancer free. Participants will be randomly assigned to either enhanced MSS or a noninteractive educational web page. Surveys will be collected from both arms at baseline and at 3, 6, 12, and 18 months to assess measures of intervention engagement, barriers, self-efficacy, habit, and SSE. The primary outcome is thorough SSE. The secondary outcomes are the diagnosis of new or recurrent melanomas and sun protection practices.

Results

Multilevel modeling will be used to examine whether there are significant differences in survivor outcomes between MSS and the noninteractive web page over time. Mixed methods will evaluate reach, adoption, implementation (including costs), and potential for maintenance of MSS, as well as contextual factors relevant to those outcomes and future scale-up.

Conclusions

This trial has the potential to improve outcomes in survivors of melanoma. If MSS is effective, the results could guide its implementation in oncology care and nonprofit organizations focused on skin cancers.

International Registered Report Identifier (IRRID)

RR1-10.2196/52689
Mobile Mindfulness Meditation for Cancer-Related Anxiety and Neuropathy: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Orasud Ariel Siritorn , Uchiyama Mai , Pagano Ian , Bantum Erin
Published: February 2024

BACKGROUND

Anxiety- and cancer-related neuropathy are two persistent effects related to treatment for cancer. Mindfulness meditation has been used with substantial impact as a nonpharmacologic intervention to mitigate side and late effects of treatment. Mobile apps are ubiquitous for most of the general population, yet have a particular relevance for cancer survivors, given that physical and geographic limitations can be present.

OBJECTIVE

This study aims to describe an ongoing trial of the Mindfulness Coach mobile app for cancer survivors.

METHODS

In this randomized waitlist controlled trial, cancer survivors experiencing anxiety- or cancer-related neuropathy (200 for neuropathy and 200 for anxiety) and who had finished primary cancer treatment were invited to participate. Data were collected at 3 time points regardless of randomization condition: baseline, 8 weeks, and 16 weeks. Both face-to-face and web-based recruitment strategies were used. The trial was opened for 2 separate primary outcomes (anxiety- or cancer-related neuropathy). The goal was not to compare these groups but to compare treatment and waitlist groups for each condition. In addition to evaluating the impact of mobile mindfulness on reported anxiety- or cancer-related neuropathy, other pain, fatigue, trauma, sleep, and satisfaction with the Mindfulness Coach app will also be assessed.

RESULTS

Outcomes of the study are expected in early 2024.

CONCLUSIONS

Mindfulness meditation has become widely practiced, and the use of mobile technology has become ubiquitous. Finding ways to deliver mindfulness meditation to people who have been treated for cancer allows for the intervention to be accessible to a larger number of survivors. The results of this intervention could have implications for further understanding the impact of mindfulness meditation on 2 persistent side and late effects of treatment of cancer, namely anxiety- and cancer-related neuropathy.

CLINICALTRIAL

ClinicalTrials.gov NCT03581357; https://ClinicalTrials.gov/study/NCT03581357

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/47745
Virtual Reality Therapy for the Management of Chronic Spinal Pain: Systematic Review and Meta-Analysis (Preprint)
Authors: Zhang Tongtong , Li Xin , Zhou Xuan , Zhan Lixia , Wu Fan , Huang Zefan , Sun Yuxun , Feng Yufei , Du Qing
Published: February 2024

BACKGROUND

The effectiveness of virtual reality (VR) therapy in adults with chronic spinal pain (CSP) is unclear.

OBJECTIVE

This study was conducted to compare the effectiveness of VR therapy and other therapies in adults with CSP, especially patients with inflammation-related pain.

METHODS

PubMed, Web of Science, Cochrane Library, Embase, and CINAHL databases were searched up to November 11, 2023. Randomized controlled trials (RCTs) comparing adults with CSP receiving VR therapy with those receiving other therapies were included. The trial registration platform as well as the reference lists of included studies and previous systematic reviews and meta-analyses were manually searched. Two independent reviewers performed study selection, data extraction, risk-of-bias assessment, and evaluation of the quality of the evidence. The weighted mean difference (WMD) was used as the effect size used to synthesize the outcome measure.

RESULTS

In total, 16 RCTs involving 800 participants were included in this meta-analysis. The pooled data from 15 (94%) RCTs including 776 (97%) participants showed that VR therapy was superior in improving pain intensity (WMD=–1.63, 95% CI –2.11 to –1.16, P<.001, I2=90%) and reducing inflammatory markers, including C-reactive protein (WMD=–0.89, 95% CI –1.07 to –0.70, P<.001, I2=0%), tumor necrosis factor-alpha (WMD=–6.60, 95% CI –8.56 to –4.64, P<.001, I2=98%), and interleukin-6 (WMD=–2.76, 95% CI –2.98 to –2.53, P<.001, I2=0%). However, no significant differences were found in terms of the spinal range of motion (ROM), disability level, or fear of movement. In addition, 10 (63%) of the included RCTs had a high risk of bias.

CONCLUSIONS

VR therapy may be an effective and safe intervention for reducing symptoms in patients with CSP, as it is shown to exert significant analgesic effects and beneficial improvements in inflammatory factor levels. However, this approach may not have significant effects on the spinal ROM, disability level, or fear of movement. Notably, the quality of the evidence from the RCTs included in this study ranged from moderate to low. Therefore, we recommend that readers interpret the results of this study with caution.

CLINICALTRIAL

PROSPERO CRD42022382331; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=382331
Using mHealth and Food Literacy to Optimize Glycaemic Control in Adults with Type 2 Diabetes in Kenya: An Exploratory Trial (Preprint)
Authors: Mokaya Moses , Kyallo Florence , Vangoitsenhoven Roman , Matthys Christophe
Published: February 2024

BACKGROUND

The prevalence of Type 2 Diabetes (T2D) is increasing at alarming rates in Low- and Middle-Income Countries (LMICs), including Kenya.

OBJECTIVE

The objective of this study is to optimize glycaemic control in adults with T2D in Kenya using mHealth by improving food literacy

METHODS

We conducted an exploratory trial in adults with T2D in two rural hospitals in Kenya. Participants were randomly selected from two hospitals. Each hospital was assigned to the mHealth intervention or control group. Participants in the intervention group received mobile text messages through a bulk SMS API (Short Message Service Application Programming Interface). Participants in the control group received monthly appointment reminders (= attention control). Participants in both groups continued receiving routine standard of care. Baseline and endline data were collected through face-to-face sessions. The primary endpoint was glycated haemoglobin (HbA1c). Secondary outcomes were food literacy and Fasting blood glucose. Intention-to-treat analyses were performed using linear mixed models.

RESULTS

A total of 84 participants were recruited; 42 were assigned to the intervention group and 42 to the control group. A total of 57 (67.8%) participants (intervention: 29, control: 28) completed the study. After 12 weeks, univariate analysis showed that HbA1c remained stable in both groups. The difference with baseline measurement in the intervention group was 0.43% [from 10.02% (SD ±3.01) to 10.45% (SD ±3.22), P=.250] compared to 0.80% [from [10.62 (±3.35) to 11.42 (±3.25), P=.414]] in the control group. After multiple linear modelling, with age and education as random factors, the overall intervention effect for HbA1c was 0.19% (95% CI -0.82; 2.21) P=.846. For food literacy, the intervention group had a higher non-significant mean score after 12 weeks [53.5% (SD ±9.2) to 60.7% (±8.3), P=.012] compared to the control group [58.7% (±9.3) to 59.9% (±11.2), P=.767]. Fasting blood glucose did not significantly change.

CONCLUSIONS

Although this study did not provide evidence on the effect of glycaemic control through food literacy for adults with Type 2 Diabetes, a focus on food literacy to improve dietary quality is still needed given its significant potential on dietary behaviour. Future research should pay attention to active patient involvement in the design and development of mHealth interventions, tracking behaviour and patient-centred outcomes, involving healthcare workers, and having a bi-directional approach.

CLINICALTRIAL

www.ClinicalTrials.gov (NCT05013294)
Evaluation of Artificial Intelligence Algorithms for Diabetic Retinopathy Detection: Protocol for a Systematic Review and Meta-Analysis (Preprint)
Authors: Sesgundo III Jaime Angeles , Maeng David Collin , Tukay Jumelle Aubrey , Ascano Maria Patricia , Suba-Cohen Justine , Sampang Virginia
Published: February 2024

BACKGROUND

Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus. The global burden is immense with a worldwide prevalence of 8.5%. Recent advancements in artificial intelligence (AI) have demonstrated the potential to transform the landscape of ophthalmology with earlier detection and management of DR.

OBJECTIVE

This study seeks to provide an update and evaluate the accuracy and current diagnostic ability of AI in detecting DR versus ophthalmologists. Additionally, this review will highlight the potential of AI integration to enhance DR screening, management, and disease progression.

METHODS

A systematic review of the current landscape of AI’s role in DR will be undertaken, guided by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) model. Relevant peer-reviewed papers published in English will be identified by searching 4 international databases: PubMed, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials. Eligible studies will include randomized controlled trials, observational studies, and cohort studies published on or after 2022 that evaluate AI’s performance in retinal imaging detection of DR in diverse adult populations. Studies that focus on specific comorbid conditions, nonimage-based applications of AI, or those lacking a direct comparison group or clear methodology will be excluded. Selected papers will be independently assessed for bias by 2 review authors (JS and DM) using the Quality Assessment of Diagnostic Accuracy Studies tool for systematic reviews. Upon systematic review completion, if it is determined that there are sufficient data, a meta-analysis will be performed. Data synthesis will use a quantitative model. Statistical software such as RevMan and STATA will be used to produce a random-effects meta-regression model to pool data from selected studies.

RESULTS

Using selected search queries across multiple databases, we accumulated 3494 studies regarding our topic of interest, of which 1588 were duplicates, leaving 1906 unique research papers to review and analyze.

CONCLUSIONS

This systematic review and meta-analysis protocol outlines a comprehensive evaluation of AI for DR detection. This active study is anticipated to assess the current accuracy of AI methods in detecting DR.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/57292
Attitudes, Motivations and Academic Performance in English among the Junior High School Students in Sulangon National High School
Authors: A. Dajuela Stephanie , O. Baes James , C. Naparota Leo
Published: February 2024

This study aimed to assess the attitudes, motivations and their relationship to academic performance in English among the Junior High School Students in Sulangon National High School during the school year 2022-2023.The data were obtained from 352 Grade 8, 9 and 10 students respectively in Sulangon National High School. A quantitative descriptive-correlational research design was employed in this study. Using frequency counting and percent, weighted mean, standard deviation, Mann-Whitney U test, Kruskal-Wallis H test, and Spearman Rank-Order Correlation Coefficient were the statistical tools used in the study. The study found out that the respondents' perceived level of positive attitude toward English was high. The respondents' perceived level of negative attitude toward English was low. Standard deviations less than 3.0 supported a high degree of homogeneity in their responses. In addition, the respondents’ perceived level of intrinsic motivation was highly motivated and the respondents’ perceived level of extrinsic motivation was also highly motivated. Additionally, the study found out that the respondents' level of academic performance was very satisfactory, which indicated that the students of Sulangon National High School experienced moderate learning in English. Standard deviations less than 3.0 supported a high degree of homogeneity in their responses. Moreover, the study found out that the respondents’ perceived level of attitude was affected by their sex. However, the respondents’ perceived level of attitude was unaffected by their age and grade level. It was also found out that perceived level of motivation was affected by their sex, age and grade level. Furthermore, data analysis revealed a significant relationship between attitudes, motivation and students' academic performance. This indicated that attitudes and motivations were significantly related to the Junior High School students' academic performance in Sulangon National High School. Hence, it is recommended that the top officials of the Department of Education in the Schools Division of Dapitan City would provide some techniques of communicative language to enhance students’ English learning and encourage them to be optimistic about the English skills practices.
ТЕХНОЛОГИЧЕСКИЕ ПРЕИМУЩЕСТВА ДАЮТ НАМ ВОЗМОЖНОСТЬ УВЕРЕННО ДВИГАТЬСЯ ВПЕРЕД
Authors: Фоменко И.Н.
Published: February 2024

ООО «Лазерный Центр», ведущий разработчик
и производитель систем лазерной обработки
в России, работает на отечественном рынке
почти 20 лет. Офисы и производственные
базы «Лазерного Центра» находятся
в Санкт-Петербурге и Москве. Компания
наладила партнерские связи со многими
промышленными предприятиями, научно-
исследовательскими институтами и вузами
в нашей стране, продукция этой марки
известна за рубежом. Лазерные станки
компании применяются в различных отраслях
промышленности: автомобилестроении,
авиапромышленности, медицине, ювелирной
промышленности, приборо- и станкостроении.
Высокая точность этих систем позволяет
использовать их для обработки материалов
в микроэлектронике. О развитии рынка
технологического оборудования в России
и перспективах применения технологий
лазерной обработки в электронике
мы побеседовали с директором
по инновациям ООО «Лазерный Центр»
Иваном Николаевичем Фоменко.
РАЗВИТИЕ РЫНКА ХИМИЧЕСКИХ МАТЕРИАЛОВ ДЛЯ МИКРОЭЛЕКТРОНИКИ РОССИИ: ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ
Authors: Книга О.
Published: February 2024

Одним из ключевых аспектов прогресса и суверенитета в области
микроэлектроники является разработка и производство химических
материалов, которые являются фундаментом для изготовления
высокотехнологичных компонентов. Рынок химических материалов
для микроэлектроники в России находится в стадии развития и обладает
значительными перспективами. Проблемы, с которыми сталкивается
отечественный рынок, включают ограниченное финансирование
исследований и разработок, отставание технологических процессов,
а также необходимость импортозамещения в свете глобальной
конкуренции и политических санкций. Вместе с тем, перспективы
развития рынка химических материалов в микроэлектронике России
связаны с наращиванием научного потенциала, модернизацией
промышленного сектора и созданием условий для инновационного роста.
СИНТЕЗ И ИССЛЕДОВАНИЕ ЭЛЕКТРОПРОВОДИМОСТИ ПЛЕНОК МЕДИ, ПОЛУЧЕННЫХ МЕТОДОМ ВОССТАНОВЛЕНИЯ ОКСИДА МЕДИ КАТОДНЫМ РАСПЫЛЕНИЕМ В АТМОСФЕРЕ ВОДОРОДА ДЛЯ СОЗДАНИЯ ПЛЕНОЧНЫХ ЭЛЕКТРОДОВ ПЕРЕМЕННЫХ ЕМКОСТЕЙ
Authors: Смирнов А.В. , Чернова О.П. , Терентьев А.А.
Published: February 2024

Рассмотрена особенность синтеза пленок меди методом катодного распыления. Проведено их оксидирование и дальнейшее восстановление пленок оксида обратно до металлической фазы. Восстановление проводилось бомбардировкой атомами меди в атмосфере водорода. Такой способ получения металлических пленок меди дает лучшую электропроводимость. Измерены поверхностные удельные сопротивления четырехзондовым методом. Исследованы УФ-вид-спектры пропускания и поглощения. Предложены практические применения выявленным зависимостям.
КЛАСТЕР ЛОМОНОСОВ: ГОД СПУСТЯ. РАБОТАЕМ!
Authors: Яминский И.В. , Ахметова А.И.
Published: February 2024

Год назад, 25 января 2023 года, состоялось торжественное открытие кластера Ломоносов [1]. За этот год удалось многое построить, усовершенствовать и значительно улучшить. Для Центра перспективных технологий ушедший 2023-й был успешным по достижениям в научно-техническом плане. Была разработана и собрана существенно улучшенная установка для совмещенной сканирующей капиллярной микроскопии и молекулярной 3D-печати, создано быстрое и эффективное решение для построения аппаратуры физического эксперимента, профессиональной измерительной и управляющей электроники с высокосовершенными "мозгами" на базе ПЛИС. Программное обеспечение "ФемтоСкан Онлайн" остается одним из лучших решений для обработки 3D-данных в микроскопии.
Caracterización de suelos y residuos de construcción para la fabricación de ladrillos y bloques de agregados reciclados
Authors: Rojas Valencia María Neftalí , Mendoza Escobe Carlos Javier , Fernández Rojas Denise Yeazul , Álvarez Cazares Eduardo , Aquino Bolaños Esperanza , Rodas Joo Alberto
Published: February 2024

En todas las ciudades del mundo se generan todos los días toneladas de residuos de construcción y demolición (RCD); por dar algunas cifras, en la Unión Europea se producen 500 millones de toneladas por año (t/año), mientras que en Estados Unidos son 170 millones de t/año y 12 millones de t/año en México. De acuerdo con los datos reportados en la normativa ambiental NACDMX-007-RNAT-2019, tan solo en la Ciudad de México (CDMX) se registran 14000 t/día por edificación de nuevas infraestructuras o renovación. A pesar de que hay varias recicladoras en la Ciudad de México, gran parte de los RCD, terminan en banquetas, calles, puentes o baldíos. Paralelo a la generación de RCD, se ve la necesidad de fabricar en México alrededor de 323 millones de ladrillos/año, los cuales se fabrican con material virgen, el cual se esta agotando y se tienen 17,000 ladrilleras artesanales que trabajan en condiciones precarias. El objetivo de este libro es dar a conocer con detalle la metodología para su aprovechamiento en la fabricación de ladrillos y bloques con agregados reciclados (AR), por lo que se dan las pautas para que un residuo sea valorizado, reutilizado y reciclado en beneficio del ambiente y de la economía de la construcción ya que se puede ayudar a disminuir la gran cantidad de RSD que se genera, además de cumplir con la Norma Ambiental de la Ciudad de México NACDMX-007-RNAT-2019, que crea la categorización y explicación de manejo exhaustivo de los residuos RCD y la obligación de reciclar o enviar a reciclaje los residuos generados en la obra. El ladrillo y bloque AR además de ser de calidad, ya que cumple con la normativa, se ubica muy bien en los requisitos ecológicos y sustentables, ya que no emplea energía para su producción, por tanto, no hay mayor generación de CO2 al ser ladrillos y bloques que no necesitan cocción.