bluuebunny/crossref_metadata_2025 huggingface dataset:
STEM Summer Camp for Girls Positively Affects Self-Efficacy
Authors: Broder E. Dale , Fetrow Kirsten J. , Murphy Shannon M. , Hoffman Jennifer L. , Tinghitella Robin M.
Published: October 2023

Women and racially and ethnically minoritized populations are underrepresented in science, technology, engineering, and mathematics (STEM). Out-of-school time programs like summer camps can provide positive science experiences that may increase self-efficacy and awareness of STEM opportunities. Such programs often use the same high-impact practices used in K–12 classrooms including relating concepts to real-world examples, engaging students as active participants in inquiry-driven projects, and facilitating learning in a cooperative context. They additionally provide opportunities for engaging in STEM without fear of failure, offer a community of mentors, and allow families to become more involved. We designed a summer camp for middle schoolers who identified as girls, low-income, and as a minoritized race or ethnicity. We describe the design of the camp as well as the results from a simple pre- and post-camp questionnaire that examined each camper’s relationship to science, scientific self-efficacy, and interest in having a job in STEM. We found an increase in self-efficacy in camp participants, which is important because high scientific self-efficacy predicts student performance and persistence in STEM, especially for girls. We did not detect an increase in interest in pursuing a STEM job, likely because of already high values for this question on the pre-camp survey. We add to the growing body of work recognizing the potential of out-of-school time STEM programs to increase scientific self-efficacy for girls and racially minoritized students.

Tweet: Summer camp for minoritized middle-school girls increases scientific self-efficacy, a characteristic that may be important for removing barriers to participation in STEM.
Effects of Picture Naming and Categorization on Concurrent Comprehension: Evidence From the N400
Authors: Hustá Cecília , Nieuwland Mante , Meyer Antje
Published: October 2023

In conversations, interlocutors concurrently perform two related processes: speech comprehension and speech planning. We investigated effects of speech planning on comprehension using EEG. Dutch speakers listened to sentences that ended with expected or unexpected target words. In addition, a picture was presented two seconds after target onset (Experiment 1) or 50 ms before target onset (Experiment 2). Participants’ task was to name the picture or to stay quiet depending on the picture category. In Experiment 1, we found a strong N400 effect in response to unexpected compared to expected target words. Importantly, this N400 effect was reduced in Experiment 2 compared to Experiment 1. Unexpectedly, the N400 effect was not smaller in the naming compared to categorization condition. This indicates that conceptual preparation or the decision whether to speak (taking place in both task conditions of Experiment 2) rather than processes specific to word planning interfere with comprehension.
N4BP1 mediates RAM domain‐dependent notch signaling turnover during neocortical development
Authors: Ma Zhihua , Zeng Yi , Wang Ming , Liu Wei , Zhou Jiafeng , Wu Chao , Hou Lin , Yin Bin , Qiang Boqin , Shu Pengcheng , Peng Xiaozhong
Published: October 2023

Notch signaling pathway activity, particularly fluctuations in the biologically active effector fragment NICD, is required for rapid and efficient dynamic regulation of proper fate decisions in stem cells. In this study, we identified NEDD4‐binding protein 1 (N4BP1), which is highly expressed in the developing mouse cerebral cortex, as a negative modulator of Notch signaling dynamics in neural progenitor cells. Intriguingly, N4BP1 regulated NICD stability specifically after Notch1 S3 cleavage through ubiquitin‐mediated degradation that depended on its RAM domain, not its PEST domain, as had been extensively and previously described. The CoCUN domain in N4BP1, particularly the “Phe‐Pro” motif (862/863 amino acid), was indispensable for mediating NICD degradation. The Ring family E3 ligase Trim21 was, in contrast to other NEDD4 family members, required for N4BP1‐regulated NICD degradation. Overexpression of N4BP1 in cortical neural progenitors promoted neural stem cell differentiation, whereas neural progenitor cells lacking N4BP1 were sensitized to Notch signaling, resulting in the maintenance of stem‐like properties in neural progenitor cells and lower production of cortical neurons.
UBR‐1 ubiquitin ligase regulates the balance between GABAergic and glutamatergic signaling
Authors: Li Yi , Chitturi Jyothsna , Yu Bin , Zhang Yongning , Wu Jing , Ti Panpan , Hung Wesley , Zhen Mei , Gao Shangbang
Published: October 2023

Excitation/inhibition (E/I) balance is carefully maintained by the nervous system. The neurotransmitter GABA has been reported to be co‐released with its sole precursor, the neurotransmitter glutamate. The genetic and circuitry mechanisms to establish the balance between GABAergic and glutamatergic signaling have not been fully elucidated. Caenorhabditis elegans DVB is an excitatory GABAergic motoneuron that drives the expulsion step in the defecation motor program. We show here that in addition to UNC‐47, the vesicular GABA transporter, DVB also expresses EAT‐4, a vesicular glutamate transporter. UBR‐1, a conserved ubiquitin ligase, regulates DVB activity by suppressing a bidirectional inhibitory glutamate signaling. Loss of UBR‐1 impairs DVB Ca2+ activity and expulsion frequency. These impairments are fully compensated by the knockdown of EAT‐4 in DVB. Further, glutamate‐gated chloride channels GLC‐3 and GLC‐2/4 receive DVB's glutamate signals to inhibit DVB and enteric muscle activity, respectively. These results implicate an intrinsic cellular mechanism that promotes the inherent asymmetric neural activity. We propose that elevated glutamate in ubr‐1 mutants, being the cause of the E/I shift, potentially contributes to Johanson Blizzard syndrome.
Lysosomes in senescence and aging
Authors: Tan Jay Xiaojun , Finkel Toren
Published: October 2023

Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction is strongly linked to cellular senescence or the induction of cell death pathways. However, the precise mechanisms by which lysosomal dysfunction participates in these various cellular or organismal phenotypes have remained elusive. The ability of lysosomes to degrade diverse macromolecules including damaged proteins and organelles puts lysosomes at the center of multiple cellular stress responses. Lysosomal activity is tightly regulated by many coordinated cellular processes including pathways that function inside and outside of the organelle. Here, we collectively classify these coordinated pathways as the lysosomal processing and adaptation system (LYPAS). We review evidence that the LYPAS is upregulated by diverse cellular stresses, its adaptability regulates senescence and cell death decisions, and it can form the basis for therapeutic manipulation for a wide range of age‐related diseases and potentially for aging itself.
Mixed convection casson fluids with the effects of porosity and radiation
Authors: N.F.M. Omar  , Ismail Zulkhibri , R. Jusoh  , R.A. Samah  , H.I. Osman  , A.Q. Mohamad
Published: October 2023

The analysis of mixed convection Casson fluid with the effect of porosity and radiation was conducted. The governing partial differential equations (PDE) in dimensional form were formulated with associated initial and boundary conditions. The PDE were transformed into dimensionless form by presenting suitable non-dimensional variables. The temperature and velocity profiles were obtained by employing the method of Laplace transform, to ensure that initial and boundary conditions involved were satisfied. The graphical representation illustrates the effects of parameters for Casson fluid, porous medium and Grashof (Gr) number, in addition to radiation. It is inferred that at the start, the velocity decreases. However, at some point the velocity rises when the Casson parameter increases. Additionally, the increasing of radiation and Grashof number has influenced the velocity to increase
Implementation of Evolutionary Algorithms to Parametric Identification of Gradient Flexible Plate Structure
Authors: Jamali Annisa , Hassan Muhammad Hasbollah , Roslan Lidyana , Hadi Muhamad Sukri
Published: October 2023

This paper focused on modelling of a gradient flexible plate system utilizing an evolutionary algorithm, namely particle swarm optimization (PSO) and cuckoo search (CS) algorithm. A square aluminium plate experimental rig with a gradient of 30° and all edges clamped were designed and fabricated to acquire input-output vibration data experimentally. This input-output data was then applied in a system identification method, which used an evolutionary algorithm with a linear autoregressive with exogenous (ARX) model structure to generate a dynamic model of the system. The obtained results were then compared with the conventional method that is recursive least square (RLS). The developed models were evaluated based on the lowest mean square error (MSE), within the 95% confidence level of both auto and cross-correlation tests as well as high stability in the pole-zero diagram. Investigation of results indicates that both evolutionary algorithms provide lower MSE than RLS. It is demonstrated that intelligence algorithms, PSO and CS outperformed the conventional algorithm by 85% and 89%, respectively. However, in terms of the overall assessment, model order 4 by the CS algorithm was selected to be the ideal model in representing the dynamic modelling of the system since it had the lowest MSE value, which fell inside the 95% confidence threshold, indicating unbiasedness and stability.
Dynamic Testing of In-Wheel Motor Based Electric Vehicle in Longitudinal Direction
Authors: Razak Muhammad Shukri Azizi , Ahmad Fauzi , Che Hasan Mohd Hanif , Jamaluddin Hishamuddin
Published: October 2023

This paper presents an investigation into the performance of in-wheel motor (IWM) based electric vehicles (IWM-EV) in the longitudinal direction. The design of IWM-EV is an innovation of the conventional go-kart vehicle with slightly modifications in steering, suspension, and braking system, which then makes use three-phase permanent magnet synchronous in-wheel motor (PMSM-IWM) at both of the rear axle wheels. An extension of that is a simulation of IWM-EV vehicle using a 5-degree-of-freedom vehicle longitudinal model that has been developed by incorporating PMSM-IWM as a drive wheel located at the rear axles. Using the simulation, vehicle dynamic control in the longitudinal direction-based Proportional-Integral-Derivative (PID) controller has also been strategized. As the intention to confirm the capability of the IWM-EV, experimental studies-based real IWM-EV hardware have been conducted. Three dynamic tests that generalized from SAE standard SAE J866-199908, namely acceleration performance at the level pavement (include acceleration tests and acceleration then braking tests) and road gradient tests at constant speeds of 10, 15 and 20 km/h, were used as the testing method. The performance areas evaluated were vehicle body speed, wheel speed, distance travel experienced by the vehicle, IWMs current, drive torque as well as the battery voltage capacity used by the vehicle. The finding indicate that the simulation results and experimental data are similar with less than 5 % error. The outcomes from this study will be considered in the design optimization of a torque vectoring control in the next research study.
Smart Home Aquaponic System Monitoring and Control with Internet of Things Using Mobile Application
Authors: W Ibrahim Wan Hanisah , Abdul Rasid Ruwaida , Hariyanto Nanang Subagyo , Mohd Faizal Nurul Amirah , Mazlan Nurul Nadia
Published: October 2023

Food security has been a recurrent concern for numerous nations, including Malaysia. Climate change and population growth exacerbate this issue by increasing necessity food. In past few years, aquaponics has proven beneficial for fish and plant production, based on the idea that if every household can generate its own fish and plants, the nation's overall food consumption will reduce. The suggested smart house aquaponics system comprises an assortment of internet-connected sensors, actuators, and ESP32 microcontrollers that continuously monitor, adjust, and record the water and air quality of the fish tank. The Internet of Things (IoT) mobile application feature can alert the user in the event of an abnormal system state in terms of maintaining the health and growth of fish and plants. The Internet of Things (IoT) mobile application feature can alert the user in the event of an abnormal system state in terms of maintaining the health and growth of fish and plants. When the pH and turbidity thresholds are surpassed, the pumps are actuated to either fill or drain the tank. The results show that the design for a smart aquaponics system that can be used in a home is able to monitor and control all the parameters that are needed to cultivate wholesome fish and vegetation.
Hypothyroidism, comorbidity and health-related quality of life: a population-based study
Authors: Wouters Hanneke J C M , Wolffenbuttel Bruce H R , Muller Kobold Anneke C , Links Thera P , Huls Gerwin , van der Klauw Melanie M
Published: October 2023

Hypothyroidism is associated with a decreased health-related quality of life (HRQoL). We hypothesized that individuals with hypothyroidism (defined as use of thyroid hormone (TH)) and especially those having an impaired HRQoL are characterized by a high prevalence of comorbid disorders and that the impact of hypothyroidism and comorbidity on HRQoL is synergistic. Presence of comorbidity was based on data obtained using structured questionnaires, physical examination, biochemical measurements and verified medication use. Single morbidities were clustered into 14 different disease domains. HRQoL was measured using the RAND-36. Logistic regression analyses were used to determine the effect of TH use on the odds of having an affected disease domain and a lower score than an age- and sex-specific reference value for HRQoL. TH was used by 4537/14,7201 participants of the population-based Lifelines cohort with a mean (± s.d.) age of 51.0 ± 12.8 years (88% females). Eighty-five percent of the TH users had ≥1 affected disease domain in contrast to 71% of nonusers. TH use was associated with a higher odds of 13 out of 14 affected disease domains independent of age and sex. In a multivariable model, TH use was associated with a decreased HRQoL across six out of eight dimensions. No significant interactions between TH use and affected disease domains were observed. TH users with an impaired HRQoL had significantly more comorbidity than those not having an impaired HRQoL. In this large, population-based study, we demonstrated that TH users had more comorbidity than individuals not using TH. The coexistence of other chronic medical conditions in subjects with TH use led to further lowering of HRQoL in an additive manner.
Diagnostic pitfalls in a young adult with new diabetes
Authors: Below Natalie , Morrison Deborah , McGowan Ruth , Jones Gregory C
Published: October 2023

A 20-year-old South Asian male presented with polyuria, polydipsia, HbA1c 81 mmol/mol, BMI 28.8 and family history of both type 1 and type 2 diabetes mellitus. As autoantibody testing was negative and c-peptide level demonstrated significant endogenous insulin secretion, type 1 diabetes was excluded. Given his age and family history, the differential diagnosis included maturity-onset diabetes of the young (MODY), a rare form of diabetes caused by a single-gene variant. A high probability of MODY was calculated and he was subsequently referred for genetic testing. Although a useful tool, the pre-test probability calculator for MODY is only validated in White Europeans. A heterogenous variant of unknown clinical significance of the NEUROD1 gene was detected, leading to gliclazide use with poor response. The patient responded well to metformin. Type 2 diabetes was considered the most likely diagnosis. This case highlights the diagnostic challenges in young patients of Asian ethnicity and the importance of interpreting genetic results of unknown significance within the clinical context. Ethnicity-specific BMI thresholds should be used when classifying patients as overweight or obese.

Learning points

Variants of unknown significance detected by genetic sequencing should be interpreted within the context of the patient’s other clinical parameters.

It is important to use ethnicity-specific BMI thresholds for obesity.

Diagnosis of type 2 diabetes mellitus at younger ages is becoming increasingly common.

The pre-test probability calculator for MODY is only validated in White Europeans; although a useful guide, results should be interpreted with caution in patients of other ethnicities.
La cultura organizacional y su rol en la adopción de tecnología en el sector agropecuario
Authors: Almanza Junco Carlos Alberto , Aponte Chirivi Diego Orlando , Parra Acosta Yenny Katherine
Published: October 2023

Colombia tiene un gran potencial como dispensa agrícola de la región, cuenta con 114 millones de hectáreas de las cuales son cultivables 39,2 millones, sin embargo, solo se tienen cultivadas 5,3 millones, lo que equivale a un 13,5 de su capacidad productiva (Editorial La República, 2022). Sumado a lo anterior, se identifica la poca adopción de tecnologías 4.0, especialmente en países en desarrollo donde se encuentra un gran potencial de crecimiento y sofisticación del sector. Si bien, en estudios anteriores se ha demostrado que el beneficio económico es la razón principal dada por los productores para adoptar la tecnología disponible, otras actitudes juegan un papel en la decisión de adopción. Este proyecto tiene como objetivo investigar el rol que cumple la cultura organizacional sobre las acciones determinantes para que las empresas agrícolas tengan la intención de adoptar tecnología 4.0, en especial, después de la coyuntura del Covid-19. Por medio de la revisión documental se busca establecer las mejores estrategias para que a través de la cultura se incrementen las actitudes de confianza hacia el uso de tecnologías agrícolas así como ser una influencia positiva en la intención de adoptar dichas tecnologías
Whatsappeando en el aula: mensajería instantánea para la socialización de contenidos didácticos
Authors: Ramírez Chinchilla Karol , Willmore Matrivier Jeremías , González Amaira
Published: October 2023

Las plataformas de mensajería instantánea demostraron la versatilidad para ser implementadas en ámbitos distintos a los círculos sociales donde tuvieron predominancia en sus inicios. Cuando los sistemas educativos se pusieron a prueba ante el COVID-19, se apoyaron de herramientas para garantizar la docencia, siendo utilizado el WhatsApp como una de las redes sociales con alta usabilidad. Este artículo busca conocer los usos y aplicaciones pedagógicas de esta herramienta para complementar la interacción entre estudiantes y docentes, implementando un guion específico de 8 minutos, con contenidos y recursos sobre contextos históricos-educativos de la época contemporánea, en una clase doctoral con 24 participantes, reunidos en TEAMS cada semana.

La metodología incluyó la búsqueda de contenidos de las temáticas para abordar en clase y un guion. Finalmente, fueron puestos en acción los pasos de la guía, quedando en una etapa final la recogida de datos de las impresiones de los participantes. Se concluye que WhatsApp tiene potencial en el aula, pero con diseños instruccionales bien establecidos, que consideren tiempos de atención, recursos audiovisuales y pertinencia del mensaje. Esta dinámica debe acompañarse de normas de convivencia claras para que los grupos habilitados con fines educativos, cumplan con el objetivo de fortalecer la enseñanza-aprendizaje.
Formación del profesorado de las universidades públicas españolas en entornos virtuales de aprendizaje
Authors: Holgado Aguadero María , Hernández-Ramos Juan Pablo
Published: October 2023

Los entornos virtuales de aprendizaje han tomado una gran relevancia en los últimos años en múltiples aspectos de la sociedad. Es por ello necesaria esta investigación, centrada en analizar el tipo de formación que ofrecen las universidades españolas a sus docentes. A través de un análisis de la oferta formativa de 28 universidades españolas, se estudia el tipo de formato en que las instituciones de enseñanza superior realizan la formación del profesorado. Se concluye destacando como la mayoría de las universidades ofrecen formación tanto presencial como a través de entornos virtuales de aprendizaje, siendo la segunda opción la mayoritaria.
Aplinkosaugos, socialinės atsakomybės ir valdysenos (ESG) atskleidimai įmonės vertės ir finansinių rezultatų kontekste: konceptualusis požiūris
Authors: Galdikaitė Aušrinė , Budrionytė Ramunė
Published: October 2023

The global practice of corporate reporting has evolved considerably over the past decades. Corporate managers have to take into account the information needs of stakeholders, which are no longer limited to the company's financial information. Non-financial information such as environmental, social and governance (ESG) disclosures are increasingly required. International organizations and governments are working together to develop ESG disclosure guidelines and standards that companies must, or can, report on ESG activities. Due to emerging ESG regulations, the integration of this non-financial information into the decision-making process is evolving into mandatory business behaviour, so it is important to understand how it can affect a firm's value and financial results. The article examines the origin of the ESG concept, methods of disclosure, motives, and the relationship between ESG and the firm's value and financial results. The results of the scientific literature analysis showed that ESG can influence the value of the company in a direct and indirect way. ESG directly affects Tobin's Q and stock prices and indirectly influences a company's value through financial performance (return on assets and equity and leverage). However, the impact does not occur in the short term due to the high implementation costs and the scale of the projects.
Katalikybės vaidmuo kasdieniame mąstyme apie Europos Sąjungą: Lietuvos atvejis
Authors:   , Garškaitė-Antonowicz Rosita
Published: October 2023

The role of Catholicism in everyday thinking about the European Union: Lithuanian case
Dosimetric evaluation of accelerated partial breast irradiation (APBI) using volumetric modulated arc therapy (VMAT) technique
Authors: Peng Jean L , McDonald Daniel G , Warwick Lisa M , Harper Jennifer L
Published: October 2023

Purpose: Five-fraction radiation therapy treatment regimens for accelerated partial breast irradiation (APBI) using intensity modulated radiotherapy (IMRT) have become increasingly used after several phase three trials demonstrated similar or reduced toxicity compared with whole breast irradiation. Improving the treatment efficiency of this technique could significantly improve delivery accuracy and tolerability, especially for treatment plans utilizing deep inspiration breath hold (DIBH) technique. The aim of this study was to determine the optimal technique for APBI, with a focus on volumetric modulated arc therapy technique (VMAT) and flattening-filter free (FFF) delivery. Methods: Ten APBI cases, five cases each left and right breast, were randomly selected. Each case was contoured following guidelines included in the APBI-IMRT-Florence Trial and planned to use both non-coplanar static-field IMRT with standard flattened-filter (FF) beam and VMAT techniques with both FF and FFF beam. For each VMAT plan, two partial arcs were used with patient-specific start and stop angles. Arc extents emulated opposed tangential fields and were chosen based on target and organ at risk (OAR) locations. Evaluated OARs included the heart, ipsilateral and contralateral lung, and normal breast. All plans were generated using the Eclipse treatment planning system (Version 15.6). A prescription dose of 30Gy delivered in 5 fractions was used for all cases. Plans were compared and evaluated using several dose metrics as well as treatment time. Results: For targets, VMAT exhibited similar coverage (V95%) but higher Dmax compared to IMRT (105% (IMRT) v.s .111% (VMAT), p=0.002. VMAT provided similar OAR avoidance compared to IMRT for the heart (Dmean, V3Gy, V0.5Gy), ipsilateral lung (V10Gy), contralateral lung (V5Gy) and contralateral breast Dmax within 10cGy/2% (p~0.005). VMAT contributed slightly lower dose outside the target in the ipsilateral breast, with an average difference in V15Gy of approximately 8% (37% (IMRT) v.s. 29% (VMAT)). Finally, because IMRT delivery is non-coplanar, and typically requires at least 5 treatment fields, co-planar VMAT reduced the total treatment significantly. VMAT with FF beam energies also used fewer monitor unites compared to IMRT with FF beam energies. The utilization of FFF beam energies for VMAT further improved delivery time compared to IMRT. Overall, VMAT with FFF beam energies reduced treatment time by approximately 20% compared to IMRT with FF beam. Conclusions: Co-planar partial-arc FFF VMAT technique produced equivalent target coverage, improved efficiency, better normal tissue sparing, and shorter delivery time compared to non-coplanar IMRT technique. Shorter delivery time also assists in the reduction of patient motion associated with breath hold. VMAT technique with FFF delivery is a suitable replacement for IMRT in APBI.
FEATURES OF BREAST CANCER IN PATIENTS OF YOUNG AGE: SEARCH FOR DIAGNOSIS OPTIMIZATION AND PERSONALIZED TREATMENT
Authors: CHEKHUN V. , MARTYNYUK О. , LUKIANOVA Ye. , MUSHII O. , ZADVORNYI T. , LUKIANOVA N.
Published: October 2023

The statistical data of the recent decades demonstrate a rapid growth of breast cancer (BCa) incidence and a tendency toward its increase especially in young women. In the structure of morbidity of women in the age group of 18—29 years, BCa ranks first and in the age range of 15—39 years, BCa is one of the leading causes of mortality. According to the data of the epidemiological and clinical studies, the young age is an independent unfavorable prognostic factor of BCa that is associated with an unfavorable prognosis and low survival rates and is considered an important predictor of the disease aggressiveness, a high risk of metastasis and recurrence. The variability of clinicopathological and molecular-biological features of BCa in patients of different age groups as well as the varying course of the disease and different responses to the therapy are mediated by many factors. The analysis of the literature data on the factors and mechanisms of BCa initiation in patients of different age groups demonstrates that the pathogen- esis of BCa depends not only on the molecular-genetic alterations but also on the metabolic disorders caused by the current social and household rhythm of life and nutrition peculiarities. All these factors affect both the general con- dition of the body and the formation of an aggressive microenvironment of the tumor lesion. The identified features of transcriptome and the differential gene expression give evidence of different regulations of the immune response and the metabolic processes in BCa patients of different age groups. Association between the high expression of the components of the stromal microenvironment and the inflammatory immune infiltrate as well as the increased vascu- larization of the tumor lesion has been found in BCa tissue of young patients. Proving the nature of the formation of the landscape comprising molecular-genetic, cytokine, and immune factors of the tumor microenvironment will undoubtedly contribute to our understanding of the mechanisms of tumor growth allowing for the development of algorithms for delineating the groups at high risk of tumor progression, which requires more careful monitoring and personalized treatment approach. Th s will be helpful in the development of innovative technologies for complex BCa treatment.
PATHOLOGICAL SIGNIFICANCE OF CDH1/E-CADHERIN GERMLINE SEQUENCE VARIANTS IN BREAST CANCER PATIENTS
Authors: Tabassum S. , Munir F. , Al Awadh A.A. , Anwar Z.
Published: October 2023

Background. Germline alterations of the CDH1 (E-cadherin) tumor suppressor gene have been reported in several epithelial malignancies like hereditary diffuse gastric cancer and lobular breast cancer. E-cadherin plays a central role in proliferation, maintenance of cell-to-cell adhesion, polarity, and epithelial-mesenchymal transition of tissue cells. It is necessary to analyze the impact of the CDH1 germline sequence variants on protein and predict its clinical significance in breast cancer (BC) progression. The aim of the current study was to evaluate the impact and association of CDH1 gene potentially pathogenic variants/likely pathogenic variants (PVs/LPVs) with the initiation and progression of BC. Materials and Methods. In this study, the clinical data of 200 BC patients have been analyzed based on the type of BC, age, grade, stage, hormonal status, and risk factors. Blood samples from 50 healthy donors were used as a control. Furthermore, CDH1 gene molecular analysis, along with in silico analysis, was provided to assess the invasiveness and progression of BC caused by the E-cadherin protein. Results. Four variants were identified by genetic screening within the CDH1 gene that included variations in exons 7, 8, 10, 11, and 13. Exon 10 had splice site mutation at position c.1337C>A, affecting the protein structure. In exon 11, there was an insertion of T base at position 1669, resulting in truncated protein compared to a normal one that can lead to the disease-causing non- sense-mediated decay and exon 13 variant c.2076T>C has already known polymorphism. In silico analysis of CDH1 showed the presence of the different variants that indicated the overall disruption of protein structure and function. Conclusions. The further functional analysis of these variants and their association with BC can be ensured by increasing the sample size and in vivo studies using mouse models.
Analysis of the Efficiency of a Power Generating Plant Operating on the Basis of the Brayton Thermodynamic Cycle and Energy Recuperation
Authors:   Anatolii Pidhornyi Institute of Mechanical Engineering Problems of NAS of Ukraine, Rusanov Andrii V. , Fedoreiko Valerii S. ,   Ternopil Volodymyr Hnatyuk National Pedagogical University, Kardaś Dariusz ,   Institute of Fluid Flow Machinery Polish Academy of Sciences, Kostikov Andrii O. ,   Anatolii Pidhornyi Institute of Mechanical Engineering Problems of NAS of Ukraine, Tarasova Viktoriia O. ,   Anatolii Pidhornyi Institute of Mechanical Engineering Problems of NAS of Ukraine, Rusanov Roman A. ,   Anatolii Pidhornyi Institute of Mechanical Engineering Problems of NAS of Ukraine, Chuhai Maryna O. ,   Anatolii Pidhornyi Institute of Mechanical Engineering Problems of NAS of Ukraine, Sukhanov Mykhailo I. ,   Anatolii Pidhornyi Institute of Mechanical Engineering Problems of NAS of Ukraine, Tretiak Serhii P. ,   Anatolii Pidhornyi Institute of Mechanical Engineering Problems of NAS of Ukraine
Published: October 2023

The thermal scheme of a power generating plant with a remote heat exchanger operating according to the Brayton cycle with energy recuperation is considered. It is assumed that the plant will work on non-certified (cheap) biofuel. It is shown that, in contrast to the usual Brayton cycle, in the cycle with energy recuperation, the greatest influence on the thermal efficiency is the heating temperature of the working medium and the internal efficiency of the main components of the plant, such as the compressor and the turbine. Also, in contrast to the usual Brayton cycle, a higher efficiency of the plant is achieved with smaller degrees of pressure reduction (increase) in the turbine (compressor). It was established that even at a relatively low temperature of the working medium heating (500 ºC), with high efficiency of the compressor and turbine, it is possible to achieve good characteristics of the power plant as a whole. At a temperature of up to 850 ºC, a thermal efficiency of 40% is achieved, but in this case the cost of materials and production increases. For a final conclusion about the possibility of using the proposed plant and its efficiency, it is necessary to conduct additional studies, in particular, of its main elements, such as a compressor, turbine, heat exchanger and others.
Calculation of the Tubular Elements Made of Pressed Profiles
Authors:   National Aerospace University ", Hrebennikov Mykhailo M. ,   Kharkiv Aviation Institute, Dibir Oleksandr H. ,   National Aerospace University "Kharkiv Aviation Institute, Kyrpikin Anatolii O. ,   National Aerospace University "Kharkiv Aviation Institute, Pekelnyi Mykola I. ,   National Aerospace University "Kharkiv Aviation Institute
Published: October 2023

This paper is dedicated to ensuring the strength of cargo equipment elements of transport aircraft. The strength of rollers of roller conveyors, which are made of standard pressed aluminum tubular profiles or composite tubular elements, is considered. The main disadvantage of these semi-finished products is the deviation of the diameter of these standard aluminum profiles, which leads to the emergence of eccentricity Δ between the axes of the outer and inner surfaces. The influence of eccentricity on the change in the values of normal and tangential stresses is considered. This analysis was carried out for standard diameters of tubular profiles at values Δ equal to half of the standard limit deviation of the outer diameter D. Calculations of normal and tangential stresses and their comparison with nominal stresses that occur in the absence of misalignment have been carried out. Calculations were made of the value c of the removal of the center of rigidity from the center of the circle of the outer border of the cross-section at different cross-section sizes of standard profiles with values of Δ equal to half of the standard limit deviation of the outer diameter D inclusively. The calculations showed an increase in tangential stresses τ in some cases by 64% and even by 213%. The obtained results indicate that the presence of Δ≠0 will have a negative effect on the resource of these elements. In order to eliminate the negative consequences, it is necessary to increase the requirements for the shape deviation of the tubular profiles in the input control.
Ethno-Cultural Features in the Development of Social Interest in Children of Roma Origin in Pre-School Age
Authors: Zdravkova Nedelina
Published: October 2023

In preschool age, according to the classics of individual psychology A. Adler and R. Dreikurs, the lifestyle is formed and social interest develops. In its development, each child is placed at the center of a unique social circle of human relationships, namely child - family - teacher. The specific study focused on the manifestations of social interest in preschool children of different ethnic origins. The comparative analysis of the level of social interest in children of different ethnic origins shows statistical differences in its development. However, a very optimistic trend is emerging related to the results of pre-school education and training. The particular advantages, sustainability and effectiveness and the integrating nature of the paradigm of modern preschool education and upbringing in our country are revealed.
Application of the Educational Escape Room in an Interdisciplinary Lesson on Art & Mathematics
Authors: Mishkova-Yotova Irina , Borisova Zoya
Published: October 2023

The application of an interdisciplinary approach in the educational process has the potential to place students in an environment where learning becomes an exciting experience, helping them discover and overcome difficulties together, promoting learning, and developing critical and analytical thinking. The article discusses the application of the "Room of Riddles" method in an interdisciplinary lesson combining visual arts and mathematics. A pedagogical practice is presented for integrating topics from the fields of visual arts and mathematics, establishing cross-curricular connections within the context of the "Room of Riddles." An interdisciplinary game is described, which combines tasks from different subject areas within one project. This approach allows students to apply their knowledge in solving a specific problem, recognize and build connections between individual disciplines, and reinforce their understanding.
Tracking online searches for gambling activities and operators in the United Kingdom during the COVID-19 pandemic: A Google Trends™ analysis
Authors: Houghton Scott , Boy Frederic , Bradley Alexander , James Richard , Wardle Heather , Dymond Simon
Published: October 2023

Background

Whilst some research has explored the impact of COVID-19 on gambling behaviour, little is yet known about online search behaviours for gambling during this period. The current study explored gambling-related online searches before, during and after the outbreak of the COVID-19 pandemic in the UK. We also assessed whether search trends were related to Gambling Commission behavioural data over the same period.

Methods

Google Trends™ search data, covering thirty months from January 2020 to June 2022, for five gambling activities and five gambling operators were downloaded. Graphical displays of the weekly relative search values over this period were then produced to visualise trends in search terms, with key dates in COVID-19 policy and sporting events highlighted. Cross-correlations between seasonally adjusted monthly search data and behavioural indices were conducted.

Results

Sharp increases in internet searches for poker, slots, and bingo were evident during the first lockdown in the UK, with operator searches sharply decreasing over this period. No changes in gambling activity searches were highlighted during subsequent lockdowns, although small increases in operator-based searches were detected. Strong positive correlations were found between search data and industry data for sports betting and poker but not for slots.

Conclusions

Google Trends™ data may act as an indicator of population-level gambling behaviour. Substitution of preferred gambling activities for others may have occurred during the first lockdown when opportunities for sports betting were limited. Further research is needed to assess the effectiveness of internet search data in predicting gambling-related harm.
Mentoring for Success: Transforming Religious Tourism Management at Islamic Boarding School
Authors: Rusmalita Santa , Patmawati Patmawati , Waldan Raziki
Published: October 2023

This study aims to carry out and analyze mentoring programs on optimizing the management of human resource management (HR), finance, and marketing of religious tourism at the Darul Fikri Islamic Boarding School. This research uses the Participatory Action Research (PAR) method with advisors, teachers, and students at the Darul Fikri Islamic Boarding School. Meanwhile, data was collected through observation, interviews, and the active participation of Islamic boarding school administrators and their students. The results showed that mentoring on optimizing the management of religious tourism at the Darul Fikri Islamic Boarding School was carried out in three stages: planning, implementation, and evaluation. At the planning stage, the researchers discussed with the stakeholder to determine the form of mentoring for managers, teachers, and students. While in the implementation stage, researchers carry out two types of mentoring: basic and advanced. The management theory and practice in the two mentoring include human resource management, financial management, and marketing management. Finally, at the evaluation stage, the researcher saw that this mentoring activity had achieved satisfactory results with the following indicators of success: the mentoring program was implemented well, the program's targets and objectives were achieved, the mentoring program received support from various parties, the management of religious tourism at the Darul Fikri Islamic Boarding School experienced to change for the better than before.
Indications of Discrimination in Regional Regulation Against Migrants in Bali (Bali Regulation Number 4 of 2019)
Authors: Muhammad Nova Effenty , Suleman Zulfitri Zulkarnain
Published: October 2023

This study aims to find out the background of the formation of Peraturan Daerah (Regional Regulation – Regional Regulation) Number 4 of 2019. The researcher found that there is an effort by the Bali provincial government to provide a legal umbrella to the Customary Village in regulating its citizens and forming awig-awig or village rules respectively as a customary village. But the migrants in Bali who are mostly Muslims in Bali feel this is a form of discrimination. To analyze this problem the author uses qualitative research. Primary data sources are from the Bali Provincial Legal Bureau, from the Village Development Office, Traditional Village administrators, and migrants in Bali.  Meanwhile, migrants on the island of Bali, the majority of whom are Muslims, feel that the Adat Village regulation as the embodiment of Regional Regulation Number 4  of 2019 is a discriminatory regional regulation because it provides a legal umbrella for the implementation of fees/collections carried out by Adat Villages in Bali. There is also competition or competition such as in the economic field, migrants or tamiu who live in Bali to try their luck and make a living are considered obstacles for residents. The 2011 bombing incident was also the peak of the conflict because the perpetrators were migrants/tamiu in Bali.  This research finds that the relationship between Islam and Hinduism in Bali appears to be harmonious, but in fact it is shrouded in several hidden conflicts called Pragmatic Tolerance. The contribution of this research is expected to benefit the meaning of religious moderation in the scheme of real religious tolerance in Indonesia.
The Waning of Kiai's Role: Transformation from Cultural Broker to Political Broker in Regional Head Election
Authors: Mufti Muslim
Published: October 2023

This study aims to analyze the transformation of the role of Kiai in the local political context, focusing on their role as cultural broker to become political broker in Banten Regional Head Election. This research involved a qualitative study involving in-depth interviews with Kiai in the Banten area and an analysis of related documents. The study's results found a change in the role of the Kiai from being a cultural broker responsible for spreading religious and cultural teachings to the public into a political broker involved in the political process and regional head elections. Kiai not only acts as spiritual leaders but also become determinants in the local political process, including in the regional head elections. Kyai uses their religious influence and authority to influence political preferences and voter behavior. They also have access to political networks and play a role in coordinating political support for certain regional head candidates. This research provides a better understanding of the transformation of Kiai's role from a cultural broker to a political broker in the political process. This study implies that it is a basis for developing a comprehensive understanding of local political dynamics in Indonesia and the role of religion in the political process.
Social Policy in the Implementation of Concurrent Government Affairs in the Nias Archipelago Area, Indonesia
Authors: Tanjung Ali Mukti , Undang Gunawan , Primanto Aji
Published: October 2023

The implementation of social policies for Concurrent Government Affairs in the Nias Archipelago Area, Sumatera Utara Province, is still experiencing inequality, especially from the aspect of budget allocation. This article aims to analyze these problems, using a qualitative descriptive method, data sourced from the Ministry of Finance of the Republic of Indonesia (2022). We use data analysis techniques through data reduction, data presentation, and drawing conclusions. The results showed that (1) out of 33 regencies/cities in Sumatera Utara Province, 5 regencies/cities in the Nias Archipelago Area, namely Nias Regency, Nias Selatan Regency, Nias Utara Regency, Nias Barat Regency, and Gunungsitoli City experienced significant imbalances in budget extreme allocations with 28 non-island (mainland) regions and below the provincial average. The lack of social policies will have a significant effect on the implementation of Optional Concurrent Government Affairs in the archipelago; and (2) Conceptually, it is important to pay attention to the principles of accountability, efficiency, externality, and national strategic interests in treating archipelagic areas through increased transfer funds – including the General Allocation Fund (DAU) and the Special Allocation Fund (DAK) - as specifically regulated in Law Number 23 of 2014 concerning Local Government. It is hoped that the novelty of this research can become material for evaluating policies of the central and provincial governments. This research can have implications for accelerating development, especially in island areas.
Sharia-Based Financial Performance Optimization for MSMEs in Banten Province, Indonesia
Authors: Itang Itang , Raharja Sam’un Jaja , Tahir Rusdin , Wahyuddin Wawan
Published: October 2023

Economic growth will be influenced by stable Small and Medium Enterprises (SMEs) and optimal financial performance based on the use of sharia fintech. This study aims to examine the financial sustainability and performance of MSMEs from the perspective of Islamic economics; examine the impact of sharia fintech use on the financial sustainability and performance of SMEs; and strengthen human resource capacity, business diversification, business productivity, and product marketing to enhance the financial sustainability and business sustainability of SMEs. The survey was conducted with a quantitative approach. Data was obtained through questionnaires distributed to 303 respondents in 4 cities and 4 districts in Banten Province. The findings indicated that company diversification and human resource capacity had an impact on the financial performance of MSMEs. The viability of SME firms is positively impacted by sharia fintech, human resource capability, company diversification, business productivity, and financial performance. Our study recommends SME business management based on the use of sharia fintech in supporting SME business sustainability in Banten Province, Indonesia. Our research contribution, apart from being empirical evidence of how to optimize MSME financial performance, also provides understanding for MSME managers in inventorying alternatives to improve financial performance by studying human resource capacity, business diversification, sharia Fintech, and business productivity, which in turn has an impact on economic growth.
Wpływ świętych oraz mistrzów wiary na osobę i nauczanie Josepha Ratzingera — Benedykta XVI
Authors: Wójtowicz Mariusz
Published: October 2023

Celem artykułu jest ukazanie wpływu wybranych świętych i mistrzów wiary na osobę i nauczanie kard. Josepha Ratzingera — Benedykta XVI. Podjęto próbę analizy nauczania kard. Josepha Ratzingera oraz jego teologicznych przemówień już jako papieża Benedykta XVI pod kątem związku eklezjologii ze świętością. Artykuł składa się z czterech punktów. W punkcie pierwszym została ukazana bliska relacja Benedykta XVI z Bogiem prawdziwie świętym i jedynym źródłem wszelkiej świętości. Następnie omówiono rzeczywistość communio sanctorum oraz więź Josepha Ratzingera ze świętymi. W punkcie trzecim zostało przytoczone nauczanie Benedykta XVI dotyczące życia świętych. Z kolei w ostatnim punkcie omówiono liturgię Kościoła, która w ujęciu Benedykta XVI, odgrywa kluczową rolę w drodze do osiągnięcia świętości.