bluuebunny/crossref_metadata_2025 huggingface dataset:
Plots and Images of Far Eastern History and Culture in Vsevolod Ivanov’s Novel “Blue Sands”
Authors:   A. M. Gorky Institute of World Literature of the Russian Academy of Sciences, Papkova Elena A.
Published: October 2023

This article examines Vsevolod Ivanov’s novel “Blue Sands” from the point of view of the episodes of the history of the Far East and its culture reflected in it. In the images of the three central characters of the novel – Commissar Vasily Zapus, Baron Ungern and Khan Chokan Balikhanov, having real prototypes in the history of the 19th – 20th centuries and created by the writer on the basis of documentary materials – Ivanov primarily emphasizes their great goal – the liberation of his people from external dependence and their unification based on a lofty idea. The analysis of the novel’s characters reveals these goals: for Zapus it is the embodiment of the idea of a world revolution in Red Asia, for Ungern it is the unification of the tribes of the Mongolian root into one Middle state, for Valikhanov – the revival of the Alash Horde – Great Kyrgyzstan. The legend of the blue sands introduced by the writer into the novel, which belongs, according to the classification of the researcher of the people’s utopia K. V. Chistov, to the “legends of the deliverers”, shows that the thoughts of all the heroes of the novel are unfeasible. The answer to the question why large-scale historical rescue projects and bringing people to the land of happiness by a certain hero-deliverer, cannot come true, Ivanov in the novel “Blue Sands” gives, relying on the traditions of folk culture of Siberia and the Far East. The article compares the perception of fortune-telling by sheep’s shoulder blades, common among some peoples of Siberia and the Far East, by the hero of the novel Valikhanov, who studied in St. Petersburg and who does not believe in the meaning of the rite and has lost his sense of homeland, and the lyrical characters of Ivanov’s poem “Zhauryn- Kora”, for whom the rite is part of a common cultural paradigms. The author of the article concludes that the writer in the novel leads the reader to the idea that the loss of a sense of connection with your people, their aspirations and customs embodied in culture, dooms to failure the best thoughts about the salvation of this people.
“…And Unseen and Unknown Tears?” Book Review: Kozlov A. E., Vasilenko A. G. et al. Vidimy miru smekh: Literatura 1860–1870-kh godov v zerkale groteska, parodii i stilizatsii [Laughter Visible to the World: Literature of the 1860–1870s in the Mirror of the Grotesque, Parody and Stylization]. Moscow, 2023, 597 p.
Authors:   Novosibirsk State Pedagogical University, Varlaro Francesco
Published: October 2023

The article notes the strengths and weaknesses of the book “Laughter visible to the world”. On the one hand, the book introduces into scientific circulation new texts and literary facts related to laughter and the comic in Russian and European culture. On the other hand, the form of the textbook is not the most successful, and one could write a monograph. The book can be used in the educational process, but it is important not to stop there and formulate an independent concept in a special scientific monograph.
Trajetória dos profissionais com crianças e adolescentes que possuem necessidades especiais de saúde
Authors: Silveira Andressa da , Santos Lairany Monteiro dos , Traczinski Juliana , Schenkel Yan Vinícius de Souza , Melo Alessandra Padilha , Soccol Keity  Laís Siepmann , Oliveira Juliana Portela de , Soster Francieli Franco , Bueno Tífani de Vargas , Vargas Tainara Giovana Chaves de
Published: October 2023

Objetivo: Conhecer a trajetória dos profissionais que atuam na clínica e na escola da Associação de Pais e Amigos dos Excepcionais e a construção de vínculo para o cuidado de crianças e adolescentes com necessidades especiais de saúde. Métodos: Estudo descritivo, de abordagem qualitativa, com 21 profissionais da saúde e da educação que atuam na associação. Utilizou-se a entrevista semiestruturada, a análise temática de conteúdo e a construção de mapas conceituais. Resultados: A trajetória dos profissionais é marcada por sentimentos distintos que partem do medo de trabalhar com crianças e adolescentes que possuem necessidades especiais, até os laços afetivos, convívio e vínculo. Conclusão: Os profissionais relatam que buscam inclusão, socialização e aquisição de habilidades dessas crianças e adolescentes, fundamentada nos saberes específicos para atuar com essa população, e também pelos laços afetivos e de confiança, que repercutem na formação do vínculo, no cuidado e no desenvolvimento de potencialidades, contudo observou-se a importância da Associação de Pais e Amigos dos Excepcionais e dos profissionais no cuidado de cada crianças e adolescentes que possuem necessidades especiais, então, sugere-se novos estudos voltados aos profissionais visto que as demandas desse público são singulares tanto para o cuidado quanto para a educação especial.
Tradução e adaptação transcultural do instrumento Nurses' knowledge of port-a-cath maintenance para o português do Brasil
Authors: Santos Priscila Sabino , Caminha Maria de Fátima Costa , Duarte Maria do Carmo Menezes Bezerra , Oliveira Luzibênia Leal , Silva Thais Gabrielle de Souza
Published: October 2023

Objetivo: Traduzir e adaptar transculturalmente o instrumento Nurses’ knowledge of port-a-cath maintenance ao português falado no Brasil. Métodos: Estudo qualitativo de tradução e adaptação transcultural, realizado em um hospital escola do Nordeste do Brasil. Embasado nas recomendações internacionais e iniciado após autorização pela autora do instrumento, adotou as seguintes etapas: tradução do original ao português por dois tradutores bilíngues nativos do português; tradução reversa por dois tradutores nativos do inglês; síntese das traduções em português por outro tradutor; revisão por comitê de juízes multidisciplinar (cinco enfermeiros especialistas no tema), pré-teste com 30 enfermeiros e reconciliação para elaboração da versão final. Pesquisa aprovada por Comitê de Ética em Pesquisa. Dados expressos em frequência absoluta e percentual, média e desvio padrão. Resultados: Questões semânticas, conceituais e de itens foram discutidas e solucionadas no comitê de juízes. Aplicação no tempo previsto (20 minutos), necessidade de agrupar perguntas e respostas. Versão final aprovada pela autora do original. Conclusão: Tradução e adaptação transcultural do instrumento original ao português do Brasil foram bem-sucedidas, mantiveram-se as propriedades semânticas, conceituais, de itens e operacionais do original e originou-se o instrumento “Conhecimento necessário ao Enfermeiro no cuidado ao port-a-cath”, apto para testar a validade e suas propriedades psicométricas.
O desenvolvimento do trabalho colaborativo durante a pandemia: o cenário mundial da atenção primária à saúde
Authors: Xavier Pedro Bezerra , Silva Ísis de Siqueira , Almeida Júnior José Jailson de , Lemos Daniel Carlos de , Guedes Dimitri Taurino
Published: October 2023

Objetivo: Identificar na literatura como se desenvolveu o trabalho colaborativo durante a pandemia da COVID-19 no contexto da Atenção Primária em Saúde (APS). Métodos: Revisão integrativa da literatura, com a finalidade de sintetizar resultados de estudos já realizados. Pesquisa realizada no PubMed, Portal CAPES e BVS, com os descritores; “primary health care”; “interprofessionality”; “COVID-19”, com o operador booleano “AND”. Setenta e nove artigos foram encontrados. Após leitura crítica, utilizando os critérios de exclusão, obtiveram-se 07 artigos. Resultados: Observa-se a notoriedade das práticas interprofissionais na APS no cenário mundial, demandando profissionais capacitados e que exerçam um trabalho colaborativo; foco centrado na comunidade; liderança e resolução de conflitos na equipe, consolidando a assistência prestada pela APS na pandemia. Observou-se a readaptação do serviço para atender a população, além das dificuldades enfrentadas pelos profissionais da saúde. Considerações Finais: Encontram-se algumas evidências capazes de ratificar a interprofissionalidade como ferramenta essencial à prática colaborativa, potencializando a APS nos diversos países, consolidando os sistemas e as redes de atenção à população e promovendo melhorias significativas na assistência. Este trabalho contribuirá para o desenvolvimento da sistematização do processo de trabalho interprofissional, melhorando a assistência prestada e favorecendo o bom funcionamento das unidades de saúde.
Thromboembolic complications during and after embolization of unruptured aneurysms: A chronological outcome in periprocedural thromboembolic events
Authors: Kanazawa Ryuzaburo , Yoshihara Tomoyuki , Uchida Takanori , Higashida Tetsuhiro , Arai Naoyuki , Ohbuchi Hidenori , Takahashi Yuichi
Published: October 2023

Background:

Ischemic complications develop after elective coil embolization procedures at a certain rate. The prevention of these events has been a longstanding issue for many interventional neuroradiologists. This study aimed to clarify whether procedural ischemic events after unruptured aneurysm embolization decrease over time with perioperative anti-thromboembolic treatment or surgical experience.

Methods:

This study included patients with cerebral aneurysms in our institution between July 2012 and June 2020. Dual-antiplatelet therapy (DAPT) was performed (Phase 1). Thromboembolic events developed at a certain rate; thus, rivaroxaban was administered with single-antiplatelet therapy (SAPT) to improve thromboembolic results (Phase 2), showing better outcomes than in Phase 1. Subsequently, DAPT was administered again (Phase 3). Ischemic complications were evaluated in each phase or compared between the DAPT group and the direct oral anticoagulant (DOAC) with the clopidogrel (DOAC+SAPT) group.

Results:

Relatively, fewer symptomatic ischemic events were noted in Phase 2 or the DOAC+SAPT group, but the outcome was not better in Phase 3 than in Phase 2. Symptomatic complications were more common in Phase 3 than in Phases 1 and 2.

Conclusion:

Ischemic complications occurred at a certain rate after endovascular procedures for unruptured aneurysms. The incidence did not decrease over time; particularly, standard DAPT plus postoperative anti-thromboembolic medication did not adequately decrease complications in Phase 3 compared to Phases 1 and 2. Therefore, accumulated experience or a learning curve could not explain the results. DOAC administration might decrease the risk of these events, but further accumulation of evidence or prospective investigation is warranted.
Spinal cord diffuse midline glioma with postoperative acute swelling: A case report and review of literature
Authors: Karita Hiroki , Tsurubuchi Takao , Amano Taishi , Koiso Takao , Sakamoto Noriaki , Ishikawa Eiichi
Published: October 2023

Background:

H3K27-altered diffuse midline glioma (DMG) is a newly classified disease according to the 5th edition of the World Health Organization classification of the central nervous system tumors. However, little is known about its progression pattern and the timing of surgical intervention, especially regarding spinal cord lesions.

Case Description:

A 26-year-old man presented with rapid muscle weakness progression in both upper and lower extremities and urinary dysfunction. Magnetic resonance imaging showed diffuse swelling of the cervicothoracic spinal cord. He underwent decompressive laminectomy with expansive duroplasty and tumor biopsy. The surgical specimen revealed DMG. Immediately after surgery, deterioration of limb paresis was observed, and the patient developed respiratory failure the day after surgery. Head-and-neck computed tomography on the 7th day after surgery showed spinal cord swelling and acute obstructive hydrocephalus.

Conclusion:

We report a rare case of a spinal DMG with acute postoperative swelling. Neurological deterioration in patients with spinal cord DMG is often exacerbated, so it is essential to suspect DMG at an early stage based on neuroimaging, and if surgery is performed on the edematous spinal cord, further rapid swelling can occur, as in the present case.
Paylaşım ekonomisi konusunda Türkiye’de yapılmış lisansüstü tezlerin betimsel içerik analizi
Authors: TEPE KÜÇÜKOĞLU Mübeyyen
Published: October 2023

Paylaşım ekonomisi konusu özellikle son yıllarda üzerinde oldukça durulan bir konudur. Dünya’da ve ülkemizde paylaşım ekonomisi platformları yaygın bir şekilde kullanılmaktadır. Özellikle konaklama, araç paylaşımı, yeme içme ve ikinci el alışveriş alanlarında karşımıza çıkan paylaşım ekonomisi iş modelinin hızla kabul görmesi ve yaygınlaşmasının temelinde bireylerin sahip oldukları ile ihtiyaç duydukları arasında bir köprü görevi üstlenmesi yatmaktadır. Paylaşım ekonomisi iş modelinin son yıllarda yaygınlaşmasıyla birlikte bu kavramın akademik alanda da kendine yer bulduğu görülmektedir. Bu çalışmanın amacı paylaşım ekonomisi konusu ile ilgili olarak Türkiye’de yayınlanmış olan lisansüstü tezlerin betimsel içerik analizini gerçekleştirmektir. Paylaşım ekonomisi kavramının bilinirliğinin artması ve kullanımının yaygınlaşmasının etkileri akademik alanda lisansüstü tezlere de yansımaktadır. Elde edilen bulgular, 2017 yılı ile birlikte paylaşım ekonomisi konusunun lisansüstü tezlerin çalışma alanına girdiğini ortaya koymaktadır. Yayınlanan tezlerin sosyal bilimler alanında ağırlıklı olduğu ve nicel yöntemlerin yoğun bir şekilde kullanıldığı göze çarpmaktadır. Araştırmalarda anket ve mülakat yöntemleri ile veri toplandığı ve özellikle paylaşım ekonomisi platformlarının kullanıcılarının örneklem içerisinde yer aldığı görülmektedir. Paylaşım ekonomisi konusuyla beraber çalışılan diğer konular arasında paylaşım ekonomisi kullanma motivasyonları, işbirlikçi (paylaşım odaklı) tüketim, davranışsal niyet ve teknoloji kabul modeli yer almaktadır.
ИССЛЕДОВАНИЕ ГУМИНОВЫХ И ФУЛЬВОКИСЛОТ МУМИЕ ПО ДАННЫМ ИК-СПЕКТРОСКОПИИ
Authors: Бухалова  Галина Романовна Бухалова  Галина Романовна , Затонская  Лина Викторовна Затонская  Лина Викторовна
Published: October 2023

На сегодняшний день одним из интенсивно развивающихся направлений современной химии является анализ продуктов жизнедеятельности и распада живых организмов – гуминовых веществ, разработка технологии и подбор оптимальных режимов по их выделению. К тому же имеется большая потребность в эффективных, экологически безопасных препаратах, какими и являются препараты на основе мумие благодаря своим главным действующим веществам – гуминовым и фульвокислотам. Именно от их количества зависят полезные свойства самого мумие. Поэтому разработка способов извлечения гуминовых и фульвокислот из мумие, изучение их свойств и практического применения является актуальным направлением научных исследований. Цель нашей работы – извлечение гуминовых и фульвокислот из мумие, исследование полученных образцов методом ИК-спектро­скопии. Используя методику, основанную на гравиметрическом определении содержания гуминовых кислот, экстрагированных из продукта щелочным раствором, определены массовые доли гуминовых кислот в двух анализируемых образцах мумие: монгольского (образец 1) и алтайского (образец 2) производства, которые составили (9,4 ± 0,2) % и (5,7 ± 0,1) % соответственно. Предложена методика извлечения фульвокислот из фракции после осаждения гуминовых кислот. С помощью ИК-спектроскопии подтверждено качественное содержание гуминовых и фульвокислот в мумие
Carbon Bond Catalysis: Dialkyl Sulfates, Alkyl Sulfonates and Alkyl Hal-ides as Catalysts in Acetal Forming and Related Reactions
Authors: Goreti Rajendar , Sarkar Tanmay , R. S. Reyno , S Keerthana
Published: October 2023

This study demonstrates a previously unexplored facet of sp3-carbon electrophiles (or alkylating agents): their potential for catalytic applications through carbon-bond interactions. In contrast to their classical SN1 and SN2 reactions, we present an al-ternate perspective, the catalytic nature of alkyl electrophiles through noncovalent interactions (NCIs). The involvement of NCIs by carbon electrophiles (possessing polar Csp3-X bonds) in stabilizing conformations of small molecules and biomole-cules has recently been discovered. Nevertheless, their catalytic role in activating small molecules has not been observed. As the "X" group evolves into an effective leaving group, carbon electrophiles develop strong positive potentials on the carbon surface (σ-hole). However, small atomic size and steric congestion resulting from the presence of four groups around the carbon atom pose challenges in establishing strong σ-hole interactions with nucleophilic acceptors. This unique behavior of alkyl electrophiles has deterred chemists from exploring their potential as catalysts in chemical transformations. In groundbreaking revelation, we demonstrate for the first time that alkyl electrophiles function as Lewis acid catalysts in activating carbonyls for acetal formation and related reactions through NCIs. We meticulously chose a range of alkyl electrophiles and discovered a striking correlation between their molecular electrostatic potential (MEP) surface energies and their catalytic efficacy in acetal-forming reactions. Our comprehensive approach, which encompassed both experimental and theoretical investigations, provided robust support for the catalytic potential of alkyl electrophiles through non-covalent carbon bond interactions.
Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease
Authors: Neto Vasco , Victor Bruno , Galamba Nuno
Published: October 2023

Sickle cell disease (SCD) is an autosomal recessive inherited disorder associated with a single substitution (Glu-beta6→Val-beta6) in the -globins of the hemoglobin molecule. This replacement induces the aggregation of deoxygenated sickle cell hemoglobin (deoxy-HbS) into helical fibers that distort the red blood cells into a rigid sickle-like shape. Despite advances in stem cell and gene therapy as well as the recent approval of a new anti-sickling drug, therapeutic limitations subsist. Herein, we investigate, through molecular dynamics (MD), the effect of nine 5-mer cyclic peptides (CPs), tailor-designed to bind to the hydrophobic pocket or its surroundings, involved in key lateral contacts of HbS fibers. The size of the CPs was chosen to minimize proteolysis and favor cell penetration, while still allowing blocking the abovementioned region. Our results show that the CPs bind to the HbS pocket, orthogonally to the surface of the protein, with some revealing exceedingly long residence times. These CPs display a moderate to high specificity, exhibiting molecular recognition events in unbiased simulations, even at a HbS:CP (1:1) ratio. Further, hydration and binding free energies from alchemical and umbrella sampling MD indicate that all CPs should be soluble, although hydrophobic peptides are slightly self-aggregation prone. The respective CP-CP dimerization free energy is, nevertheless, higher (by a factor of ~ 6) than the HbS-CP binding free energy. A much lower (by a factor of ~ 6) HbS-CP binding free energy, longer residence times, and higher specificity are also found relative to a previously reported CP with modest in vitro antisickling activity. These results indicate that some of the CPs designed herein, namely, VVVVV and VFVFV (neutral), VEVFV (charge -1), VEVEV (charge -2), and VKVKV (charge +2) have the potential to reduce the concentration of aggregation-competent deoxy-HbS, by blocking or delaying the formation of the lateral contact at the homogeneous nucleation and/or fiber growth stages.
SOCIOECONOMIC POLICY EVALUATION: PARTISANSHIP AND PARTISAN BIAS EFFECT
Authors: Merkulova Tamara , Martynenko Maryna
Published: October 2023

Public support of socioeconomic reforms is one of the most important factors for their successful implementation, and conversely, lack of public approval doesn’t allow achieving the expected effect and may result in negative externalities. In this regard, it is relevant to study the origins of people’s opinions and factors affecting their evaluation of social and economic policies. This paper is devoted to the following aspects of this multidimensional problem as partisanship and partisan bias. Their research has been actively promoted by foreign scientists, but so far presented extremely limited in Ukrainian literature. In this paper the critical review of foreign scientific papers devoted to this topic is presented; the main hypotheses about the influence of party identification on public opinion and the effect of partisan bias are highlighted; features of the methodology are noted and research results are summarized. The methodology used by foreign specialists for research of this problem is based on experimental methods, among them the main place belongs to laboratory experiments. A laboratory experiment means observing people’s behavior (participants’ behavior) under strictly controlled conditions when the influence of uncontrolled factors is limited to a minimum. In foreign studies of partisan bias and its influence on citizens' evaluation of socioeconomic policies, laboratory experiments serve as the main tool for testing hypotheses. The results of the research give evidence, on the one hand, that the partisan bias mechanism provides wide possibilities to manipulate the people’s opinion and public opinion in general, on the other hand, that correct objective information about the policy content and goals can significantly weaken the partisan bias effect. Foreign studies prove that party signal influence depends on the people’s properties, policy content, political systems, and party characteristics. In Ukraine, there is a lack its own research in this field, however, as democratic institutions, civil society, and people’s political consciousness and activity develop, these studies become more relevant to the political and economic life in Ukrainian society.
La Obertura: Lecciones Inaugurales de una Universidad Eudista. Mayo de 2020 - Febrero de 2022
Authors: Henao Gaviria Héctor Fabio , Castilla Devoz Harold de Jesús , Oñoro Consuegra Fidel , Fajardo Guevara Carlos , Alzate Duque Jesús Hernán
Published: October 2023

Nuestros amables lectores encontrarán en este primer libro sobre las Lectio Inauguralis, cinco profundos planteamientos acerca de la Doctrina Social de la Iglesia, alineados dentro del pilar institucional de UNIMINUTO. Unos y otros pueden gestar reflexiones y acciones para que nuestra Institución pueda hacer de Colombia un país más justo, más solidario, participativo y en paz. Estoy plenamente convencido que entonces nuestra opción, unida a la del Padre Rafael García-Herreros por los pobres y necesitados, hará eco por la verdadera justicia social como aporte de la academia para el cambio.
Transformación sostenible de la guadua en Cundinamarca: laminados, biochar y carbón activado
Authors: Melo Jaimes John Andersson , Pita Castañeda Diber Jeanette
Published: October 2023

La guadua es una planta reconocida por sus beneficios ambientales, que por generaciones ha hecho parte de las comunidades rurales. Su aprovechamiento sostenible se ha convertido en un reto, en la medida que quienes cuentan con este material en sus fincas, muchas veces desconocen cómo transformarla en productos con valor agregado, cómo mantenerla y sacar su máximo provecho. No obstante, el abastecimiento de la guadua como material para la transformación sostenible es el primer paso a la hora de pensar en la elaboración de cualquier producto, y es el tema que más se ha desarrollado en los territorios por sus diferentes actores. El aprovechamiento de los guaduales está regulado por un marco normativo que entrega los lineamientos para aprovechar al máximo sus potencialidades sin afectar la disponibilidad de la guadua a futuro.
Developing Human Reproductive Organoids to Combat Infertility: A Literature Review
Authors: Mohapatra Ronit
Published: October 2023

Introduction: Infertility affects a significant portion of the population, up to 1 in 5 North American adults. The lack of accurate reproductive models has limited clinical research with 15% of infertility cases remaining untreatable. However, advances in stem cell technology have allowed for the development of organoids, artificial 3D organ systems in culture (also referred to as “organs-in-a-dish”), as accurate, human-specific research models. We propose that organoid systems are valuable tools to advance reproductive health research and aim to assess major progress and limitations of this technology relating to infertility. Methods: A literature review was performed using the PubMed and Google Scholar databases. We identified 10 studies published from 2017 onwards that focused on the application of reproductive organoid systems in infertility treatments or the development of model systems for infertility research. These studies were compared and analyzed in terms of methodology, clinical applications, and potential limitations. Results: Both female and male reproductive tracts (FRT and MRT) are complex systems with many potential causes for infertility. We identified the ovary, fallopian tubes and endometrium in the FRT and the prostate, epididymis and testes in the MRT as the most promising current organoid models. Organoid systems have been used in transplantation techniques to treat the infertility disorders of Asherman’s syndrome and azoospermia. As well, organoids function as disease models for drug screening including chemotherapeutic compounds or as physiologic models to study fundamental mechanisms of fertility considering factors like ageing and environmental gonad toxicity. Discussion: The various novel applications of reproductive organoids emphasize their potential in infertility research and the development of personalized medicine. However, lack of cross-organ communication and minimal microbiome modeling limit organoid-based research. Conversion from animal to human organoid models is also a major obstacle to be addressed for the advancement this technology in reproductive health science. Conclusion: This review highlights the unique benefits of using organoids over traditional research models as well as the most critical research gaps in this field to guide future studies and accelerate the development of clinical techniques for human infertility treatment.
Evaluating Route of Administration for Bisphosphonates in Patients with Metastatic Breast Cancer to the Bone: A Literature Review
Authors: King Christine P. , Huynh Jennifer P.
Published: October 2023

Introduction: Metastatic bone disease, the condition where tumor cells spread from their origin tissue to bone, is common for breast and prostate cancer. Two main hypotheses, referred to as Paget’s “seed and soil” theory and Ewing’s anatomical theory, describe the homing of cancer cells to the bone. When breast cancer becomes metastatic and the tumor spreads to the bone, skeletal-related events can occur. Many patients use bone-modifying agents such as bisphosphonates (BPs) to manage skeletal deterioration. Given the longstanding history of BPs, this review aims to evaluate the efficacy and side effects of oral versus intravenous BPs as adjuvant treatment options for patients with metastatic breast cancer. Methods: Relevant literature was sourced through a search of the PubMed and Google Scholar databases, using established inclusion criteria for screening papers published between 1889 and the present. Results: Currently, there are three generations of BPs. Literature on the different generations reports that studies mainly use first-generation BPs for Paget’s disease and there is no significant effect of first-generation BPs on breast cancer survival rate. Second-generation BPs showed effectiveness in prolonging the progression of bone metastasis and decreasing distant recurrences to the bone in breast cancer patients. In attempts to improve the health outcomes of BPs, researchers examined third-generation BPs and found that they decreased skeletal-related events and pain levels. Discussion: Comparing oral to intravenous administration of BPs, both had overall similar effects in reducing skeletal complications; however, the side effects resulting from BP use vary depending on the route of administration. Patients administered intravenous BPs exhibit an acute phase response and renal complications, while oral BPs cause disruptions in the gastrointestinal tract. Cost-effectiveness varied by study depending on assumptions made in the analytic models. Conclusion: This novel review investigates the development of each generation of BPs to compare the implications of oral and intravenous administration. By accounting for differences across the three generations, healthcare providers can make informed decisions about BPs and create treatment plans tailored to the individual patient. Future research may explore how preexisting risk factors contribute to the occurrence of adverse effects of BP use.
Violence against women during the pandemic from the viewpoint of a tertiary forensic medicine clinic
Authors: Yıldırım Mahmut Şerif , Sezen Sude , Aksakallı Sevcan , Savaş Cemal Emre , Cengiz Mustafa , Pekşen Koç Betül , Kayhan Uğur
Published: October 2023

COVID-19 pandemic and measures to combat the pandemic caused an increase in the risk of violence against women. In this study, it was aimed to examine the change in violence crimes against women evaluated in a tertiary forensic medicine clinic over a two-year period by focusing on periods of lockdown and domestic violence. Victims of violence against women who admitted to our center between 01/01/2020 and 12/31/2021 were included in the study. Patient files and forensic reports were used to acquire information regarding the age, date of the incident, relationship of the offender, type of incident, usage of weapons, injuries sustained, and if the incident was domestic violence. The ages of 121 cases evaluated ranged from 10 to 88 years, and the mean age was 36.1 (SD=17.6) years. When the mean number of incidents per day was examined, it was shown that cases of domestic violence were most common during the lockdown period. When all cases were considered together, it was shown that the highest mean number of cases occurred in the first days following the restrictions. Violence against women increased during the periods of the pandemic. In cases of domestic violence, as expected, the most significant rise occurred during lockdown periods. The 24-hour period following the lockdown application has been identified as the most intensive time of violence against women during the pandemic.
Physician migration through the lens of patient and physician rights: A qualitative evaluation from the Turkish Parliament
Authors: Önal F. Gülsüm
Published: October 2023

Physician migration, which maintains global importance in terms of health ethics, is a phenomenon that has gained momentum in Türkiye throughout the recent years. However, there are limited studies on this subject, and no research has been found that addresses the issue in terms of health ethics and rights. In this regard, this study is likely to contribute to a better understanding of Türkiye’s physician migration. Furthermore, draw some attentions for solutions and health policies through the lens of physician and patients’ rights. The population of the retrospectively designed study consists of research proposals related to physician migration in the Turkish Grand National Assembly and the statements of members of parliament in the general assembly proceedings during the same period. Data obtained from transcripts that were searched using keywords such as “physician,” “doctor,” “health,” “migration,” and “foreign countries” were coded and subjected to content analysis using a qualitative method. Multifaceted findings emerged in the context of physician and patient rights in the categories of “reasons,” “consequences,” and “solutions”. It was observed that certain rights were more affected by the process, that rights were interdependent, and that structural regulations in the healthcare system were necessary for their fulfillment. There is a need for legislation that would concretely demonstrate physician rights in a legal status. In the context of physician rights, the prominence of “reasons” and the emphasis on patient rights in the “consequences” category also point to a significant ethical dilemma. The dilemma between the autonomy of the physician and the principle of justice, which is central to the ethical debate about physician migration, has been confirmed, indicating a need for further in-depth research on this topic. The purpose of this study is to evaluate how physician migration, which has recently increased in Türkiye, is addressed by members of the Turkish Grand National Assembly in terms of physician and patient rights.
Implementation of a broad public health approach to COVID-19 in Sweden, January 2020 to May 2022
Authors: Tegnell Anders , Bessö Anna , Björkholm Britta , Byfors Sara , Carlson Johan , Tegmark Wisell Karin
Published: October 2023

In 2020, the world had to adapt to a pandemic caused by a then novel coronavirus. In addition to its direct impact on morbidity and mortality, the COVID-19 pandemic brought unprecedented control measures and challenges to both individuals and society. Sweden has been seen by many as an outlier in the management of the pandemic. It is therefore of special interest to document the actual management of the pandemic in Sweden during its first 2 years and how public health was affected. In the authors opinion, within the Swedish context, it has been possible to achieve a similar level of effect on mortality and morbidity through recommendations as was achieved through stringent legal measures in comparable countries. This is supported by comparisons of excess mortality that have been published. Furthermore, we see in the available data that the consequences on mental health and living habits were very limited for the majority of the population. Trust in public institutions is high in Sweden, which has been important and is part of the context that made it possible to manage a pandemic with relatively ‘soft’ measures. We acknowledge challenges in protecting certain vulnerable groups, particularly during the first and second wave.
3D PRINTING TECHNIQUE TO DOCUMENT AND PRESERVE TRADITIONAL DESIGNS OF CHANNAPATNA TOYS
Authors: Kanchana M. Kamakshi
Published: October 2023

Dasara Doll festival is a tradition during the Navaratri Hindu festival celebrations in South India. The festival of Navratri is celebrated in a very interesting and unique way at homes, which is commonly known as Bombe Habba or Golu or Kolu (Kannada) or Bommala Koluvu (Telugu) or Bommai Kolu (Tamil) or simply Dasara dolls. This tradition involves a toy festival that is celebrated by families across Karnataka and Andhra Pradesh, Tamil Nadu. Family toys are arranged and displayed to invited guests as part of the festival. Channapatna town close to Bangalore and Mysore is the hub of the toy making industry catering to the demand for such toys. Artisan families have been engaged in the manufacture of toys for many centuries. Designs and manufacturing techniques remained within artisan families and the knowledge transfer is through word of mouth from parents to children. Kondapalli Toys of Andhra Pradesh are made by artisans in Kondapalli which is located close to Vijayawada in Andhra Pradesh and has a similar history. The changing lifestyles in the present day have altered the way festivals are celebrated, and the patronage of such traditional crafts is on the decline. The creation of an express highway between Bangalore and Mysore has changed the road route and bypassed Channapatna town reducing the footfalls at the retail shops which sold toys for hundreds of years. Artisans are forced to explore other avenues of employment and the risk of losing the art technique is real. The portfolio of designs is dwindling, and many models are very rare and difficult to obtain from the market; they become antique collection pieces of a few individuals. Conserving the designs through CAD techniques and making prototypes using 3D printing is an effective way to preserve them. CAD documentation can be used to train a new generation of artisans or enthusiasts across the country. This will open new markets for the products and will sustain the art and design. This paper attempts to outline the technique and make a few 3D-printing prototypes with detailed drawings and present the results.
Profil Sensori Minuman Yuzu (Citrus junos) Komersial
Authors: Nurlela Lani , Muhandri Tjahja , Adawiyah Dede Robiatul , Saraswati Saraswati
Published: October 2023

The yuzu product development process in general was related to the level of consumer preference or acceptance which could not be separated from the sensory aspect. The purpose of this study was to obtain a map of the sensory profile characteristics of the ideal product, to identify the sensory and emotional profile characteristics, as well as to observe the correlation between sensory attributes and preference for yuzu drink based on consumer perceptions. The methods used included consumer surveys, ideal profile methods, and check-all-that-apply (CATA) as consumer-based methods. The consumer survey involved 108 respondents to assess general consumer preferences. The sensory evaluation panel consisted of 47 consumer panelists. The samples for sensory evaluation included 4 commercial yuzu beverage products available in Jakarta. The results of ideal profile mapping for yuzu beverage products with codes A, B, C, and D indicated that product A closely matched the ideal sensory profile, with sensory attributes of sweetness, acidity, freshness, citrus, and bitterness. The yuzu drink samples with codes A and C provided the same distinctive sensory attributes both in the mouth and upon swallowing, with their respective distinctive attributes being sweetness and freshness. The sweetness and freshness were correlated with consumer preferences (overall liking) when the product was in the mouth, and the freshness was correlated with preferences when the product was swallowed. The emotional profile mapping results revealed that consumers favored products associated with the "pleasure" emotion as found in product A and "relaxing" emotion as found in product D.
A Study of Functional Relationship for Rice (Padma) Response to Nitrogen
Authors:   Assitant Professor, Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore 641003, . RETHINAM
Published: October 2023

With the objective of finding the optimum level of fertiliser for the rice variety Padma, an experiment was laid out with six levels of nitrogen. The quadratic form of response curve was found to be the best fit. It was found that additional yield due to fertiliser application was seemed tobe maximum at the level of 160 kg of nitrogen por ha and the additional income at this level was Rs. 1,694. 50 per ha.
Effect of Irrigation Levels and Forms of Manures on Rice Varieties IR 8 and IR 20
Authors:   Assitant Professor, Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore 641003, A MOHAMED ALI , Y.B MORACHAN ,   Professor and Head of Agronomy, Tamil Nadu Agricultural University, Coimbatore 641003
Published: October 2023

A field experiment in rice conducted during kharif 1970-71 revealed that sub- mergence of land throughout the growing period with a depth of 5 cm water was necessary for higher grain yields. Water requirements from planting to harvest were 1417 mm and 1217 mm for the rice varieties IR 8 and IR 20 for the above treatment. Ammonium sulphate influenced grain yields better than the organic manures on equal nitrogen basis 1. e. 187.5 kg N/hs and it gave higher production per Kg of N and higher out turn per rupee of expenditure among the manures tried.
Rooting Pattern as a Selection Parameter of Wheat Varieties Under Moisture Stress
Authors:   Department of Agricultural Botany, J.N.K.V.V Jobalpur, D.K TIWARI , D.P NEMA ,   Department of Agricultural Botany, J.N.K.V.V Jobalpur, J.P TIWARI ,   Department of Agricultural Botany, J.N.K.V.V Jobalpur
Published: October 2023

Sixteen wheat varieties were studied under rainfed condition in heavy black sol with a view to evaluate their yield potential on the basis of root growth pattern in mois ture stress condition, Varieties viz, C 306, Hy 633. Hy 11. Hy 65, PKD 14 HD 1625 with greater number, deep vertical penetration and a more horizontal spread of seminal roots proved to be drought escaping and high yielding. Earlier initiation of crown roots coupled with their more number and greater length was found to be of great significance for an additional moisture and nutrient absorption and substantial vigour, which ultima tely result in higher productivity.
Effect of Methods of Intercropping Maize and Cowpea on the Quality of Forage
Authors:   Department of Agriculture jaipur, S.C SHARMA , H.G SINGH ,   professor and Head Dept of Agronomy  University College of  Agriculture Udaipur 313 001
Published: October 2023

The study indicates that cross planting of maize with cowpea surpassed all other methods of intercropping in terms of crude proteins mineral matter ether extract and nitrogen free extract production of fodder without increasing crude fibre content.
Studies on Simazine in Hybrid Maize (Var. Ganga-5) Under Graded Levels of Nitrogen
Authors:   Assitant Professor, Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore 641003, A.V RAJAN , S SANKARAN ,   Associate Professor, Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore 641003, Y.B MORACHAN ,   Profesor and Head, of Agronomy, Tamil Nadu Agricultural University, Coimbatore 641003
Published: October 2023

Simazine as pre-emergence application at 1.00 and 1.75 ka a, i/ha was offective in controlling weeds in maize and superior to two hand weedings. The grain yield in herbicid-treated plots were on par with twice hand weeded plots. The sub-herbicidal dose of simazine (0.25 kg a. i. / ha) increased the protein content of grain than the other treatments. Nitrogen levels did not influence the weed population but the weed weight increased with each increment of nitrogen. Grain yield was maximum under 120 ke N/ha but it was on par with 60 and 90 kg N/ha.
Effect of Foliar Application of Nitrogen on Winter Cambodia Cotton (Gossypium hirsutum)
Authors:   Associate Professor, Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore 641003, A CHAMY , S KAMALANATHAN ,   Professor of l Botany, Tamil Nadu Agricultural University Coimbatore  641 003, S.D PETER ,   Associate Professor of l Botany, Tamil Nadu Agricultural University Coimbatore  641 003, R KALIAPPA ,   Professor of Agronomy (Water management) Tamil Nadu Agricultural University Coimbatore  641 003, K.S JAHANGIR ,   Instructor Botany Tamil Nadu Agricultural University Coimbatore  641 003
Published: October 2023

Effect of graded doses of nitrogen applied partly through soil and partly as foliar on the yield and quality of MCU.5 cotton grown in the winter season was studied. The results revealed that 45 kg N/ha applied to soil plus 7,5 kg N/ha applied through foliage recorded maximum yield of kapas, number of botls per plant and profit per /ha compared to the present recommended dose of 60 kg N/he as soil application.
Constraints Faced by the Groundnut Growers in Adoption of Cluster Frontline Demonstration of Villupuram District
Authors:   Department of Agricultural Extension and Rural Sociology, TNAU, Coimbatore- 641 003, India, M Karthickraja , R Premavathi ,   Department of Agricultural Extension and Rural Sociology, TNAU, Coimbatore- 641 003, India, PP Murugan ,   Department of Agricultural Extension and Rural Sociology, TNAU, Coimbatore- 641 003, India, K P Vanetha ,   Agricultural Extension, ICAR- KVK, Tindivanam, Villupuram- 604 001, India
Published: October 2023

India is one of the largest producers of oilseeds in the world and occupies an important position in the Indian agricultural economy. The productivity of groundnut farming is currently declining due to pest and disease attacks, use of old and traditional low-yielding varieties. To tackle the issues demonstrations on cluster mode are essential. Cluster Frontline Demonstration (CFLD) is conducted by Subject Matter Specialists (SMSs) and scientists in a systemic manner on selected farmers field to spread the new variety and groundnut production technologies. The ICAR- KVK, Tindivanam had organized CFLDs on groundnut crop in two villages viz., Nolambur and Kilmavilangai. Therefore, the study aimed to know the profile characteristics of CFLD beneficiary farmers and to encounter the major constraints faced by groundnut growers. To get an adequate sample size, 60 CFLD beneficiaries were selected randomly for the present study. The data were collected by using a pre-tested interview schedule. Garrett’s ranking technique and percentage analysis were used to analyze the data for meaning interpretation. The majority of beneficiaries belonged to middle age category (61.66%), majority of male beneficiaries (80.00%), educated upto middle school (40.00%), land holdings of 1 to 2 ha (68.33%) as small land, 20- 30 years of farming experience in oilseeds (80.00%), participated in one training (66.67%), medium level of extension agency contact (66.67%) and mass media exposure (56.67%), 55 per cent of farmers were adopted new practices after the successful adoption of other members. The major constraints include poor labour availability, poor transport facilities, lack of proper marketing channels and lack of technical knowledge. Hence, CFLD showed that medium to high level profile characteristics and improved adoption of new technologies.
COMÉRCIO INTERNACIONAL; COMÉRCIO EXTERIOR; GLOBALIZAÇÃO; CONCORRÊNCIA; ENTRAVES ENTRE PAÍSES.
Authors: Alencar Ednaldo Monçã de
Published: October 2023

Esse artigo científico, foi elaborado pelo acadêmico de pós graduação em comércio exterior , graduado pela FMU e pós graduado pela FAVENI. Esse artigo foi feito através dos conhecimentos do acadêmico em comércio exterior e comércio internacional e pesquiza bibliográfica, não contém plágio, é um artigo fidedígno, elaborado por um profissional de comércio exterior sem o auxílo de orientador, exceto a faculdade.
The Curation of American Patriotism: The American Legion and The Story of Our American People
Authors: Lewis George
Published: October 2023

Abstract: Attempts to frame the memory of military conflicts have often been driven by veterans' organizations whose members participated in the fighting. This article argues that, in the United States, the newly formed American Legion sought to control the national narrative of the Great War as part of its wider, ambitious project of Americanization and "100% Americanism," in particular via the curation and development of a school history textbook intended to deliver its ideology into every schoolhouse in the United States. In so doing, it revealed the contested nature of history writing, the depth of contemporary concerns over the value of history as a discipline and the difficulties of eliding the history of the American past with the concept of Americanization, especially in terms of sectionalism, race, immigration and empire.
The Biography of a Face: Virginia Woolf's Orlando
Authors: Parvulescu Anca
Published: October 2023

Abstract: Virginia Woolf's novel Orlando: A Biography can best be described as a literary portrait. Woolf draws a portrait of the titular character—a composite of literary and visual artworks—as perpetually youthful. Through this portrait, the novel traces a change in the history of the physiognomic face in modernity—from Orlando's memorable face-to-face with Queen Elizabeth to her search for meaning in the faces around her in London in 1928. The face of Orlando, which Woolf forcefully inserts into the history of the portrait, is sketched in a formal relation to absent faces in the history of portraiture—women's faces and racialized faces. An engagement with Paul Mpagi Sepuya's recent photographic reflections on Orlando reveals the version of modernist queerness dramatized by the novel to be mediated by racial difference.