bluuebunny/crossref_metadata_2025 huggingface dataset:
Transferência de atitudes em relação a presidentes da república
Authors: Bufara Gonzaga Pereira Pedro ,   Centro Universitário de Brasília (UniCeub), Borges Moreira Márcio ,   Centro Universitário de Brasília (UniCeub)
Published: July 2024

O presente experimento investigou se um procedimento de emparelhamento de acordo com o modelo seria suficiente para formar classes de equivalência compostas por fotografias de presidentes da república brasileiros e figuras abstratas. Adicionalmente, investigou, utilizando-se uma escala de diferencial semântico, se após a formação da classe de equivalência de estímulos haveria transferência de função das fotografias de presidentes para as figuras abstratas. Cinco estudantes universitários participaram da pesquisa. Cada participante avaliou os estímulos experimentais utilizando uma escala de diferencial semântico antes e depois de passar por tarefas de treino de discriminações condicionais e teste de emergência de relações de equivalência de estímulos. Os resultados obtidos demonstraram tanto a formação de classes de equivalência quanto a transferência de função dos estímulos com significado pré-experimental para os estímulos sem significado pré-experimental. Os resultados descritos neste trabalho demonstram como atitudes em relação a políticos podem ser transferidas para novos estímulos.
Efeito do contexto competitivo no relato de desempenho de tarefas acadêmicas em crianças
Authors: Iamada Larissa ,   Centro Universitário de Brasília – UniCEUB, de Medeiros Carlos Augusto ,   Centro Universitário de Brasília – UniCEUB
Published: July 2024

O presente trabalho investigou o efeito da competição sobre a correspondência verbal ao solicitar três crianças, de 10 e 12 anos a relatarem seu desempenho em tarefas de matemática na presença e na ausência de um contexto competitivo. A cada tentativa, os participantes realizavam uma operação matemática e relatavam tê-la acertado ou não. Nas condições de linha de base, os relatos não eram consequenciados. As condições de reforçamento de relatos de acerto ocorreram com e sem o contexto competitivo, no qual as crianças eram informadas do desempenho de oponentes. Foram aplicados treinos de correspondência, onde apenas relatos acurados eram reforçados com e sem contexto competitivo. A acurácia dos relatos foi alta nas linhas de base para dois participantes, a qual foi enfraquecida nas condições de reforçamento de relatos de acerto, principalmente diante do contexto competitivo. A acurácia de seus relatos foi restabelecida nos treinos de correspondência, principalmente no contexto competitivo. A acurácia dos relatos de erro do outro participante foi enfraquecida no reforçamento de relatos de erro, porém, não foi restabelecida nos treinos de correspondência. Os resultados dão suporte à suposição de que a competição pode ser uma variável de controle na correspondência verbal de crianças em tarefas acadêmicas.
Soft skills in cultural management: new challenges
Authors: Arce Rangel Luis Miguel ,   Universidad del Rosario
Published: July 2024

The purpose of this study is to explore the current scenario of soft skills in cultural management. A literature review is conducted, relying on secondary sources that contribute to knowledge regarding topics such as education, work, culture, cultural management, and soft skills. As a result, several soft skills arepresented with the support of a Venn diagram, in which a comparison is made between the proposals of the Organisation for Economic Co-operation and Development (OECD), the Federation of Cultural Management Professionals of Spain (FEAGC), and the International Council of Museums (ICOM). It is evident that creativity, communication (interpersonal communication), cooperation (teamwork), curiosity (learning orientation, training), planning, tolerance, and optimism (self-motivation) are some of the most relevant soft skills in the field of cultural management, as well as in the workplace and education. However, further research is needed since the bibliography is limited, and soft skills may vary according to the context of each region.
El subgénero 𝑃𝑖𝑛𝑎𝑐𝑜𝑑𝑒𝑟𝑎 Schaum del Hemisferio Oeste: Subgrupo 𝐶𝑦𝑚𝑖𝑛𝑑𝑖𝑠 (𝑃𝑖𝑛𝑎𝑐𝑜𝑑𝑒𝑟𝑎 ) 𝑙𝑎𝑡𝑖𝑢𝑠𝑐𝑢𝑙𝑎 (Coleoptera: Carabidae: Lebiini: 𝐶𝑦𝑚𝑖𝑛𝑑𝑖𝑠 Latreille)
Authors: Hilchie Gerald ,   Retired, University of Alberta, Ball George E. ,   10629-64 Ave. NW, Edmonton, Alberta, CANADA
Published: July 2024

A taxonomic treatment of the latiuscula species subgroup of subgenus Pinacodera Schaum, genus Cymindis Latreille with a key to species. Twelve species and two subspecies are treated, eleven (ten species, one subspecies) are described as new. One species, C. punctifera (LeConte), is re-ranked as a subspecies of C. punctifera (sensu lato). Listed alphabetically are the species and subspecies: Cymindis apache, new species (Ramsey Canyon, Cochise County, Huachuca Mountains, Arizona, U.S.A.); C. crenatoverpa, new species (Volcán Ceboruco, Nayarit, México); Cymindis cuyuteca new species(Cuautla, Jalisco, México); C. geminata, new species (Cuernavaca, state of Morelos, México); C. huichilobos, new species (km 117, Oaxaca-Puerto Angel road, state of Oaxaca, México); C. latiuscula (Chaudoir) (Dzibilchaltun Archaeological Zone, ca. 16 km north of Mérida, Yucatán, México); C. punctifera punctifera LeConte, new rank (Madera Canyon, Santa Rita Mountains, Pima County, Arizona,U.S.A.); C. punctifera toltec, new subspecies (Mazatlán, Sinaloa, México); C. rugofrons, new species (19.5 km NW Los Volcánes, Jalisco, México); C. tonatiuh, new species (15 km SE Nochixtlán, Oaxaca, México); C. yaqui, new species (Cave Creek Canyon, S.Fork, Chiricahua Mts., Arizona, U.S.A.); C. zacapa new species (12-14 km S. San Lorenzo, Departamento Zacapa, Guatemala); and C. zapotec new species (San Gabriel Mixtepec, Oaxaca, México). Cymindis punctifera (LeConte 1884), a junior synonym of C. cribrata (Chaudoir 1875), is the valid species name because the latter is a junior secondary homonym of Cymindis cribrata LeConte 1859 (= C. pilosa Say 1823). Ecologically, the species of the latiuscula subgroup are geophile or arboreal mesophiles, occupying tropical wet and dry, oak- pine[lowland to montane], and cloud forests, to scrubby desert vegetation, their resting places are under bark or bromeliads.These beetles are active in year-round, principally March to September. They may be found from sea level to 3060 m, with most foundbelow 1800 m.
Hidden in the cracks, a new species of Scorpion from Michoacan, Mexico (Scorpiones: Vaejovidae)
Authors: Contreras Félix Gerardo A. ,   Centro de Estudios en Zoología (CZUG), Centro Universitario de Ciencias Biológicas y Agropecuarias (CUC- BA), Universidad de Guadalajara (UdG), Navarrete Heredia José L.
Published: July 2024

A new species of Vaejovis is described for Michoacan, Mexico belonging to the nigrescens/nitidulus group, the less diverse group of species from the genus. This species has a preference for synanthropic environments and inhabits rock walls within the city limits. Additionally, the pictures of the hemispermatophore are presented and characters are named according to new terminology. This species is named honoring Dr. Gabriela Castaño Meneses for her great contributionsto arthropods research in Mexico and the world.
Del suelo al dosel: Celebrando la inspiradora trayectoria científica de la Dra. Gabriela Castaño-Meneses
Authors: Nava-Bolaños Angela ,   Laboratorio de Ecología de Artrópodos en Ambientes Extremos, Unidad Multidisciplinaria de Docencia e Investigación, Facultad de Ciencias, Universidad Nacional Autónoma de México, Campus Juriquilla, Santiago de Querétaro, Querétaro, México, Ibarra-Garibay León , Ibáñez-Huerta Abel , Rodríguez Elizalde Israel de Jesús , Verver Andrés , Pérez-Velázquez Daniela , Hernández-Tirado Arturo Erubiel ,   Posgrado en Filosofía de la Ciencia, Facultad de Filosofía y Letras, Universidad Nacional Universidad Nacional Autónoma de México
Published: July 2024

En este artículo, deseamos rendir un homenaje a la Dra. Gabriela Castaño-Meneses por su extraordinaria trayectoria científica, la cual ha sido una fuente constante de inspiración para los miembros del Laboratorio de Ecología de Artrópodos en Ambientes Extremos. A lo largo de su carrera, la Dra. Castaño-Meneses ha contribuido a la ecología y taxonomía de artrópodos, destacándose en el estudio de colémbolos, ácaros y hormigas. Su investigación ha abarcado una amplia gama de hábitats, desde el suelo hasta el dosel de los árboles, pasando por ambientes cavernícolas y acuáticos. Su trabajo no solo tiene un impacto significativo a nivel nacional e internacional, sino que también contribuye al entendimiento de los procesos ecológicos y a la conservación de la biodiversidad en un contexto marcado por el cambio climático y la pérdida de hábitat y de biodiversidad. Más allá de su destacada labor científica, la Dra. Castaño-Meneses se distingue como un referente emblemático en nuestras vidas, trascendiendo por su calidad humana en nuestro paso por su laboratorio.
Antibacterial activity of jamblang leaf ethanol extract (Syzygium cumini) against the growth of Propionibacterium acnes
Authors: Yulianti Maria Fransiska Priska , Amat Anita Lidesna Shinta , Hutasoit Regina Marvina , Pakan Prisca Deviani
Published: July 2024

Background: Propionibacterium acnes is a bacterium found on the skin that plays a significant role in acne vulgaris. The inappropriate use of antibiotics can lead to resistance, necessitating the search for alternative therapies from plants with high antibacterial potential. One such plant is jamblang (Syzygium cumini), which has demonstrated antibacterial properties.
Objective: This research aims to test the antibacterial activity of jamblang leaf extract against the growth of P. acnes.
Method: The study employed an experimental design with a posttest-only control group design. The treatment groups consisted of a positive control (clindamycin), a negative control (sterile distilled water), and jamblang leaf extract groups with concentrations of 100%, 50%, 25%, 12.5%, and 6.25% (n=4). Data analysis was conducted using the One-Way ANOVA statistical test.
Results: The jamblang leaf extract exhibited antibacterial potential against the growth of P. acnes. The extract showed strong antibacterial activity at concentrations of 100%, 50%, 25%, and 12.5%, and moderate antibacterial activity at a concentration of 6.25%.
Conclusion: This suggests that jamblang leaf extract could be a promising alternative therapy for treating acne vulgaris, offering a natural solution to combat antibiotic resistance.
Metodologias ativas nas práticas pedagógicas da Geografia do Ensino Fundamental II: reflexões para uma introdução crítica
Authors: Fonseca Tiago Boruchovitch
Published: July 2024

O conceito de metodologias ativas de ensino tem recebido destaque como potencial transformador do modelo escolar, tido como tradicional e problemático por centralizar o exercício docente na transmissão de informações pelos professores. Apesar da popularização recente dessa perspectiva, sabe-se que preocupações e proposições semelhantes estiveram presentes nos debates pedagógicos por décadas. O crescimento da utilização da terminologia “metodologias ativas” ocorre, por vezes, sem a consolidação de debates teóricos primordiais para sua introdução crítica nos ensinos disciplinares. Assim, tal perspectiva tem sido apropriada de diversas maneiras, trazendo inovações mais ou menos consistentes em relação à lógica do ensino tradicional. Dessa forma, o objetivo do presente artigo configura-se em compreender as formas pelas quais a noção de metodologias ativas tem sido apropriada em práticas de ensino de Geografia no segmento do Ensino Fundamental II. Para tanto, realizou-se uma revisão bibliográfica sistemática que localizou quatorze trabalhos que apresentaram práticas pedagógicas na geografia do Ensino Fundamental II e que se identificaram explicitamente com a perspectiva das metodologias ativas. Os trabalhos foram objetos de análises quantitativas e qualitativas. Os resultados evidenciaram amplo crescimento recente da introdução de metodologias ativas na Geografia do Ensino Fundamental II, muitas vezes marcada pela ausência de discussões teóricas sobre essa perspectiva. Os trabalhos ancorados em debates teóricos consolidados na pedagogia foram mais capazes de produzir práticas de ensino coerentes com os princípios das metodologias ativas, quando comparados com aqueles que enfatizaram a discussão em torno das referências específicas sobre metodologias ativas, sem dialogar com outros debates pedagógicos.
Literature Review of Practice Evaluation of Good Drug Distribution Methods at Public and Private Sector Pharmaceutical Distribution Facilities in Indonesia
Authors: As'hari Yanuar , Wiedyaningsih Chairun , Yasin Nanang Munif
Published: July 2024

To ensure that the quality of pharmaceutical products is maintained throughout the distribution chain, it is necessary to implement Good Distribution Practices at distribution facilities that distribute pharmaceutical products. This literature review explores the evaluation of Good Drug Distribution (GDP) or CDOB guideline practices in pharmaceutical product distribution facilities engaged in the public and private sectors in Indonesia. The literature review method used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. Articles were searched using the Google Scholar database and restricted to those related to GDP published from 2018 to 2022. The literature was reviewed using questions to assess studies organized by Population, Exposure, and Outcome (PEO) criteria. Articles obtained were then identified, screened, eligibility, then selected based on inclusion and exclusion criteria resulting in 19 pieces that will be extracted data. Of the 19 articles, the study was conducted in several pharmaceutical distribution facilities such as the Health Office, Puskesmas, Hospitals, Pharmacies, and Pharmaceutical Wholesalers spread across Indonesia. All articles used descriptive methods to show the conformity of implementing Good Distribution Practices guidelines. Some studies still do not use the latest regulation, namely the Food and Drug Administration Regulation Number 6 of 2020 concerning Amendments to BPOM Regulation Number 9 of 2019 concerning Technical Guidelines for Good Distribution Methods. The suggestions that can be made include the need for studies related to the evaluation of Good Distribution Practices of pharmaceutical distribution facilities in the public or government sector and studies on distribution facilities in Eastern Indonesia
Pengaruh Pemberian Telur Rebus dan Madu Terhadap Kadar Haemoglobin Remaja Putri di Posyandu Remaja Raemadia Wilayah Kerja Puskesmas Seba Nusa Tenggara Timur
Authors: Berel Stiesia , Suralaga Cholisah , Lail Nurul Husnul
Published: July 2024

Masa Remaja (Adolescence)  merupakan masa transisi dari kanak-kanak  menuju masa dewasa  ditandai dengan terjadi perubahan-perubahan baik fisik, psikis dan psikososial. Perubahan fisik yang terjadi pada remaja  ditandai  dengan pertumbuhan tinggi badan dan berat badan. Sehingga tubuh membutuhkan gizi tinggi karena berhubungan dengan komposisi tubuh, kurangnya zat gizi seperti zat besi pada remaja dapat menimbulkan berbagai macam  masalah kesehatan seperti  Anemia. Penelitian ini bertujuan untuk mengetahui adanya pengaruh pemberian telur rebus dan madu terhadap  kadar hemoglobin remaja putri di Posyandu remaja raemadia wilayah kerja Puskesmas Seba Nusa Tenggara Timur. Desain penelitian ini yaitu  quasi eksperimen dengan pre and post test design with control group yaitu melakukan  pre test - post test . Populasi pada penelitian adalah 65 remaja putri yang anemia . Tehnik sampel yang digunakan dalam penelitian ini adalah purposive sampling. sampel yang digunakan dalam penelitian ini adalah total sampling yaitu 30 sampel, dan dibagi menjadi 2 yaitu 15 sampel untuk kelompok intervensi dan 15 untuk kelompok kontrol. Dari  hasil penelitian didapatkan uji statistic menggunakan uji Independent t-test diperoleh mean pada selisih kelompok intervensi dan selisih kelompok kontrol sebanyak 0,019 gr/dl dan nilai p 0,000 (p <0,05). Dapat disimpulkan bahwa ada pengaruh konsumsi telur rebus dan madu terhadap kadar hemoglobin remaja putri  di posyandu remaja raemadia wilayah kerja Puskesmas Seba Nusa Tenggara Timur.
Gambaran Tingkat Pengetahuan dan Faktor-Faktor Ibu Hamil yang Tidak Menerima Vaksin Covid-19 di Kelurahan Petuk Katimpun
Authors: Devitasari Ivana , Safitri Neneng
Published: July 2024

Latar Belakang: Penularan covid-19 tidak mengenal siapa saja tidak terkecuali ibu hamil, ibu hamil lebih rentan terinfeksi penularan covid-19 mengingat ibu hamil memiliki sistem imunitas tubuh yang rendah. Oleh karena itu ibu hamil harus di prioritas untuk mendapatkan vaksin covid-19 untuk mencegah terjadinya angka kematian dan kesakitan pada ibu hamil dan bayi. Ibu hamil di Kelurahan Petuk Katimpun RT 01-09/RW 02 berjumlah 51 orang. Ibu hamil yang sudah menerima vaksin berjumlah 13 orang dan yang tidak menerima vaksin berjumlah 38 orang. Metode: Desain penelitian ini adalah Deskriptif dengan jenis sampling yaitu Total Sampling. Jumlah populasi sebanyak 51 responden dan sampel berjumlah 38 responden. Pengumpulan data menggunakan kuesioner, Analisis data menggunakan editing, coding, skoring, tabulating, penyajian data disajikan dalam diagram pie. Hasil: Berdasarkan hasil penelitian dari 38 responden dalam kategori pengetahuan baik hasil penelitian mengenai tingkat pengetahuan ibu hamil tentang vaksin covid-19 di Kelurahan Petuk Katimpun yaitu diperoleh data 28 responden (73,7%) berpengetahuan baik, 9 responden (23,7%) berpengetahuan cukup dan 1 responden (2,6%) berpengetahuan kurang. Kategori pengetahuan baik dipengaruhi oleh beberapa faktor seperti usia, pekerjaan, pendidikan, pernah atau tidak mendapatkan informasi, dan sumber informasi yang didapat. Kesimpulan: Untuk itu upaya yang harus dilakukan oleh tenaga kesehatan adalah dengan memberikan informasi yang baik dan benar secara berkesinambungan agar tidak ada keraguan bagi ibu hamil untuk mendapatkan vaksin Covid-19 dan berkolaborasi dengan tenaga kesehatan setempat untuk memberikan vaksin.
Pengaruh Infusa Daun Bayam (Amaranthus tricolor) Terhadap Penurunan Kadar Glukosa Darah Terhadap Hewan Coba Mencit in Vivo
Authors: Putri Kartika , Umar Anugrah , Mursyid Murni
Published: July 2024

Penelitian ini dilakukan sebagai upaya dalam melestarikan bahan alam yang berpotensi sebagai antidiabetes yaitu daun bayam merah (Amaranthus tricolor), mengandung senyawa kimia seperti flavonoid, tanin, fenol, alkaloid serta saponin yang dapat menurunkan glukosa darah. Penelitian ini bertujuan untuk mengetahui pengaruh infusa daun bayam merah (Amaranthus tricolor) dalam menurunkan kadar glukosa darah serta konsentrasi yang paling efektif untuk menurunkan glukosa darah. Dilakukan di Laboratorium Farmasi Universitas Muhammadiyah Palopo pada bulan Agustus 2023. Merupakan jenis penelitian eksperimenta dengan tahapan pengambilan sampel, pembuatan infusa daun bayam merah (Amaranthus tricolor), pembuatan larutan na CMC 1%, pembuatan suspensi glibenklamid, pembuatan larutan glukosa sebagai penginduksi terhadap hewan uji. Dibutuhkan waktu 3 hari dalam perlakuan terhadap mencit dengan pengukuran kadar glukosa darah. Hasil penurunan glukosa darah yang diperoleh yaitu pada kontrol negatif sebesar 15,40 mg/dL, kontrol positif sebesar 57,40 mg/dL, infusa 20% sebesar 42,13 mg/dL, infusa 25% sebesar 58,20 mg/dL dan infusa 30% sebesar 58,27 mg/dL. Dari hasil uji one way ANOVA dan dilanjutkan dengan uji duncan diperoleh hasil yang bervariasi atau berbeda signifikan antara kontrol negatif dengan kelompok perlakuan (kontrol positif, infusa 20%, 25% dan 30%). Disimpulkan juga bahwa yang paling efektif dalam menurunkan kadar glukosa darah yaitu infusa 30% dengan nilai rata-rata 58,27 mg/dL.
Hubungan Kadar Merkuri dalam Darah Terhadap Kadar Nilai Hematokrit pada Komunitas Ibu-Ibu di Muara Angke Kota Jakarta Utara
Authors: Kristiawati Kristiawati , Harningsih Tri
Published: July 2024

Konsumsi ikan merupakan rute utama paparan merkuri pada manusia. Ibu-ibu yang bertempat tinggal di Muara Angke merupakan kelompok yang memiliki resiko terpapar merkuri melalui konsumsi ikan. Tujuan penelitian ini untuk mengetahui hubungan antara kadar merkuri terhadap nilai hematokrit. Merkuri yang terakumulasi pada tubuh akan menggangu sintesis heme dan menyebabkan terjadinya hemolisis sel darah merah sehingga terjadi penurunan sel. Desain penelitian yang dilakukan adalah analitik observasional dengan pendekatan cross sectional dengan pengambilan sampel secara quota sampling sebanyak 15 responden. Pengambilan darah untuk pemeriksaan merkuri menggunakan sampel whole blood (Na-Heparin) dan pemeriksaan hematokrit menggunakan sampel whole blood (K2EDTA). Pengukuran kadar merkuri darah menggunakan alat Agillant 7700X dengan metode ICP-MS. Pengukuran hematokrit menggunakan alat XN-550 metode DC Impedance method. Hasil pemeriksaan kadar merkuri dalam darah diperoleh dari 15 sampel yang diperiksa, terdapat 2 sampel yang kadar merkuri dalam darahnya diatas nilai rujukan dengan kadar hematokrit normal. Hasil pemeriksaan kadar kadar hematokrit dari 15 sampel yang diperiksa terdapat 5 sampel dengan kadar kadar hematokrit kurang dari normal serta kadar merkuri dalam darah normal. Berdasarkan hasil uji statistik diperoleh hasil signifikansi sebesar 0,002 dan nilai r sebesar 0,590 yang bersifat positif. Terdapat hubungan kadar merkuri dalam darah terhadap kadar hematokrit, dengan arah hubungan semakin tinggi kadar merkuri maka kadar hematokrit juga akan meningkat.
Penerapan Metode WWHAM pada Praktik Swamedikasi diApotek Wilayah Banjarmasin Timur
Authors: Ballo Gitria Putri , Yuwindry Iwan , Palimbo Andriana
Published: July 2024

Metode WWHAM (Who, What symptoms, How long, Action, Medication) adalah salah satu metode penggalian informasi yang digunakan oleh apoteker untuk menganalisis masalah kesehatan pada praktik swamedikasi sebelum apoteker melakukan pelayanan konseling dan pemberian informasi obat. Tujuan penelitian ini untuk mengetahui gambaran penerapan metode WWHAM yang dilakukan oleh apoteker pada praktik swamedikasi di apotek berdasarkan lima kriteria tingkat penerapan pada penggalian informasi, pemilihan obat dan informasi obat. Penelitian ini adalah penelitian observasional deskriptif dengan teknik purposive sampling, maka diperoleh 30 sampel yaitu apoteker yang bekerja di apotek wilayah Banjarmasin Timur dan peneliti melakukan wawancara menggunakan kuisioner sebagai panduan yang telah valid dan reliabel. Hasil menunjukkan bahwa apoteker yang bekerja di apotek wilayah Banjarmasin Timur telah menerapkan praktik swamedikasi dengan persentase sebesar 85,5% pada penggalian informasi, 92,5% pemilihan obat dan 83,6% pada informasi obat. Apoteker telah menerapkan metode WWHAM pada praktik swamedikasi, tetapi belum maksimal 100% .
Review Penggunaan Interval Docetaxel pada Kemoterapi
Authors: Wijayanti Nunuk
Published: July 2024

Modalitas terapi pada kanker salah satunya dengan kemoterapi. Dosetaksel merupakan salah satu obat sitostatika yang digunakan pada kemoterapi  berbagai jenis kanker. Dosetaksel dapat digunakakan dalam regimen tunggal maupun kombinasi dan dapat diberikan dalam berbagai interval baik mingguan atau interval 3 minggu. Pada kemoterapi kanker payudara, docetaxel sebagai rejimen tunggal diberikan dengan dosis 60-100 mg/m2. Sedangkan pada interval mingguan dapat diberikan pada dosis dosis 35 mg/m2 selama 3 minggu diikuti dengan 1 minggu istirahat Dosis maksimal penggunaan dosetaksel di Indonesia adalan 100mg/m2.  Tidak ada perbedaan secara signifikan terkait efikasi dari adanya perbedaan interval, namun dalam beberapa artikel disebutkan bahwa penggunaan dosetaksel mingguan lebih direkomendasikan pada pasien dengan riwayat toksisitas sebelumnya.
Formulasi Nanoemulsi Ekstrak Bunga Melati (Jasmine sambac L.) dengan Teknik Self Nano Emulsifying Drug Delivery System (SNEDDS) Sebagai Anti Jerawat
Authors: Malahayati Siti , Nastiti Kunti , Audina Mia , Noval Noval
Published: July 2024

Acne vulgaris atau jerawat merupakan masalah kulit berupa infeksi dan peradangan yang disebabkan oleh infeksi bakteri Propionibacterium acne. Ekstrak bunga melati mampu menghambat pertumbuhan bakteri, namun pada sediaan krim tidak menunjukkan adanya daya hambat terhadap bakteri, sehingga perlu pengembangan formula dalam bentuk sediaan nanoteknologi yaitu nanoemulsi yang dibuat dalam sistem penghantaran obat Self-Nanoemulsifying Drug Delivery System (SNEDDS). Penelitian ini bertujuan untuk meningkatkan efektivitas anti jerawat dan stabilitas sediaan, sehingga didapatkan formula yang optimal. Metode penelitian yang digunakan adalah dengan memformulasikan ekstrak bunga melati menjadi sebuah sediaan SNEDDS. Evaluasi yang dilakukan yaitu uji stabilitas, turbiditas, emulsification time, karakterisasi nanoemulsi, pH, dan uji aktivitas antibakteri. Hasil Penelitian diperoleh 5 formulasi yang memiliki stabilitas yang stabil, dilakukan evaluasi uji tubiditas F5 mendekati 100%, ukuran partikel paling kecil F8 dan paling besar F5, nilai zeta potensial F4 dan F8 memenuhi persyaratan, uji pH F1 memenuhi persyaratan, uji emulsification time dan uji indeks polidispersitas semua formulasi memenuhi persyaratan, serta formula yang memiliki daya hambat terbesar F5. Berdasarkan hasil dapat disimpulkan bahwa formulasi 5 merupakan formulasi yang optimal dapat menghambat pertumbuhan bakteri P. acne.
KONSTRUKSI IJMA’ DALAM PERSPEKTIF MUHAMMADIYAH
Authors: Aisyah Aisyah , Lisnawati Lisnawati , Reza Muhammad , Oktorisa Tanti
Published: July 2024

Ijma' is one of the complementary sources of law, in addition to the Quran and Hadith. Because, the two main sources of Islamic teaching, namely the Quran and Hadith alone are not enough to answer all the problems that exist in society, and are also supported by many differences of opinion among the mujtahid. In general ahkam, what is meant by nash here is only the Quran and Hadith. Ijma' is not part of the nash (ghair al-nash). This is based on the opinion that Ijma' is more of a process rather than a product. Muhammadiyah believes that Ijma' cannot be used as a primary source in religious teachings. This research is a qualitative writing, which refers to the library research method, with sources from other Islamic books and journals. Thus, the result of the analysis obtained is that Muhammadiyah does not make Ijma' as a source of basic law, but only positions it as a paractextual source
KONSEP HUKUM HAK DAN KEWAJIBAN WARGA NEGARA PERSPEKTIF PIAGAM MADINAH
Authors: Syarif Nawaz , Habibi Ahmad
Published: July 2024

In the course of history, we have seen that conflict occurs due to different needs, which is why sometimes the law appears as a way to mediate between one another. In this case, the Medina Charter, which is the state Constitution, is the legal basis regarding the rights and obligations of its people. This research is legal research which focuses on analyzing using a conceptual approach how the legal concept of the Medina Charter presents the rights and obligations of every human being as a citizen. The Medina Charter teaches us lessons about Brotherhood (Al-Ikha), Equality (Al-Musawa), Tolerance (Tasamuh), Deliberation (Al-Tasyawur), mutual help (Al-Ta'awun), Justice (Al-Aku). The points given here play a very important role in life in society, for example the brotherhood that is given will form a bond that requires other people to respect and appreciate each other's fellow human beings. Brotherhood also creates peace because they feel a bond. The equality provided in the Medina charter also brings us to the same position without having to differentiate, and this also makes tolerance happen in people's lives
Bangladesh-India Land Boundary Agreements, 1974-2015: Context, Correlations and Territoriality
Authors: Rabbani Mohammad Golam Rabbani
Published: July 2024

Bangladesh and India share 4096.7 km. land boundary, which was drawn between India and the eastern part of Pakistan (East Bengal) by the Radcliffe Award during the partition of 1947. This boundary became the Bangladesh-India boundary after the liberation of Bangladesh in 1971. Therefore, the Pakistan-India land boundary disputes over the un-demarcated boundary, adverse possessions and enclaves transformed into Bangladesh-India ones. These land boundary disputes witnessed one summit-level agreement between Pakistan and India and three summit-level agreements between Bangladesh and India. However, the land boundary disputes were eventually resolved under the land swap deal of 2015. This striking background led to the question as to why these issues were hung up for 68 years, what contexts led to several summit-level agreements on the same issues, and what were the correlations among the agreements. Against this background, this article attempts to shed light on how India, being the big neighbour, dominated the entire trajectory of the land boundary disputes and how it changed its agreed positions from one agreement to another. However, the main objective of this article is to see whether India’s territoriality towards its border with Bangladesh was gradually transformed into the pattern of a zero-sum game during the period from 1974 to 2015, and what was the corresponding territoriality of Bangladesh.
Journal of the Asiatic Society of Bangladesh (Hum.), Vol. 69(1), 2024, pp. 89-106
Actinic keratosis and field cancerization: Profile of patients of a dermatology service in the city of Lagarto/SE
Authors: Oliveira Iza Brito de , Oliveira Neto Manoelito Cardoso de , Arrais Sara Lani Regattieri , Santana Fabrício Passos , Carregosa Jamylle Catarina Passos , Nogueira Júnior Osmar Alves , Andrade Luciana Nalone
Published: July 2024

Objective: to evaluate the epidemiological profile, pattern of sun exposure, protective measures and lesion characteristics of patients with actinic keratosis and field cancerization in the city of Lagarto/SE. Methodology: this is a descriptive, cross-sectional and quantitative study using questionnaires over a period of 12 months. Results: the sample included 127 participants, the majority was female, with light skin phototype,  low education, average age of 60 years and occupations more exposed to the sun. Participants tended to expose themselves to the sun during the period with the highest incidence of ultraviolet rays, the majority used mechanical photoprotection measures, but only about half of them used sunscreen. Of the total, 124 participants reported having skin lesions, most for more than 1 year, with associated symptoms and in areas of the body most exposed to the sun. Conclusion: most participants belong to risk groups for actinic keratosis and/or skin cancer, work in occupations exposed to the sun, in addition to being exposed at the most critical times of the day. The use of mechanical photoprotection barriers was superior to the use of sunscreen. The characteristics of the interviewees' skin lesions may indicate a delay in reaching the specialized service, making it important to adjust the local flow to optimize care for this population and ensure their early referral.
O cuidado pré-natal na prevenção da violência obstétrica: Uma revisão integrativa
Authors: Souza Akaciane Mota , Nascimento Davi Leonel Araujo , Souza Deborah Cristina Silva , Gomes Karolyny Dias , Morais Allana Tarcisa Santos , Rabelo Andreia Ferreira de Aragão
Published: July 2024

Objetivo: Identificar o papel do cuidado pré-natal na prevenção da violência obstétrica em gestantes e puérperas. Métodos: Trata-se de uma revisão integrativa de literatura, a coleta de dados foi realizada em dezembro de 2023 nas quatro bases de dados, sendo elas: PubMed, LILACS, BDENF e SciELO. Foram incluídos estudos primários relacionados ao cuidado pré-natal como forma de prevenção da violência obstétrica em gestantes e puérperas, escritos em idiomas português, inglês e espanhol. Resultados:  A pesquisa derivou em 9 artigos adequados para os critérios de inclusão da revisão, que se concentraram na base de dados LILACS (55,56%), seguidos da BDENF (22,22%) e PubMed (22,22%). Identificou-se ações para prevenção da violência obstétrica pelos enfermeiros na atenção primária sobre a percepção e conhecimento de formas de violência obstétrica e orientações sobre os direitos da mulher no pré-natal, parto e pós-parto. Conclusão: Conclui-se que o pré-natal humanizado e qualificado apresenta papel significativo na prevenção da violência obstétrica, permitindo o empoderamento da gestante sobre a assistência ao parto fisiológico e sobre seus direitos na assistência gravídico-puerperal.
Avaliação da função pulmonar e da capacidade funcional em pacientes idosos pós-COVID
Authors: Andrade João Paulo Ferreira , Costa Rômulo Carvalho , Nascimento Ellis Souza do , Carvalho Ana Carolina Ribeiro , Oliveira Letícia Ferreira de , Chaves Bisneto Pedro de Medeiros , Cajueiro Catarina Andrade Garcez
Published: July 2024

Ao fim de 2019, na cidade chinesa de Wuhan, ocorreu uma crescente curva exponencial de casos de pneumonia ocasionada por um novo vírus, nomeado de Síndrome Respiratória Aguda Grave do Coronavírus 2 (SARS-CoV-2). Ao longo desses 4 anos, milhões de pessoas em todo o mundo vieram a óbito em decorrência do quadro clínico ocasionado por essa infecção. A maioria dos casos são leves e assintomáticos, no entanto, devido a algumas comorbidades, como a velhice, alguns indivíduos podem desenvolver uma forma mais severa da doença. Esta pesquisa tem a finalidade de avaliar a função pulmonar em pacientes idosos que foram acometidos pela COVID-19. Para isso, foram recrutados por conveniência, 30 pacientes atendidos em um serviço de fisioterapia de uma capital nordestina. Os idosos foram alocados em dois grupos, o grupo estudo (GE) e o grupo controle (GC), formados respectivamente por aqueles que foram infectados previamente pelo Sars-CoV-2 e pelos não acometidos pela doença. A análise dos dados levantados foi feita considerando um valor α de p < 0,05, para significância estatística. A média de idade dos indivíduos com COVID-19 e sem COVID-19 não apresentou diferença significativa, caracterizando uma amostra homogênea. Com relação aos sinais vitais, os pacientes pertencentes ao GE apresentaram uma maior taquicardia. Na espirometria, o Índice de Tiffeneau (FEV1/FVC) apresentou p = 0,020, no qual o GE resultou numa média de 88,94 ± 10,33% e, o GC, 72,67 ± 21,09%, apontando um maior comprometimento do fluxo aéreo do GE.
Fisioterapia no desenvolvimento motor de neonatos prematuros na Unidade de Terapia Intensiva Neonatal
Authors: Gonçalves Francisco Felipe Lima , Santos Saulo Barreto Cunha dos , Martins Lucas Erick Feijó , Silva Victor Andrei Carvalho Vaz da , Araújo Samara Menezes , Mendes Livia Sayuri Félix , Silva Alexia Guilherme e , Alves Katielly Pinto
Published: July 2024

O nascimento prematuro ocorre antes das 37 semanas de gestação, resultando em possíveis atrasos neuropsicomotores em crianças, desse modo à estimulação motora se torna uma peça fundamental para evolução do desenvolvimento, além de organizar os sistemas corporais. O objetivo do estudo é descrever, através de uma revisão integrativa a atuação da fisioterapia no desenvolvimento motor de neonatos prematuros na Unidade de Terapia Intensiva Neonatal. Este estudo trata-se de uma revisão integrativa, onde foi consultado as bases de dados Scielo, PubMed e BVS. Os resultados obtidos foram que, o fisioterapeuta desempenha papel crucial na colaboração do desenvolvimento motor de neonatos, por meio de abordagens objetivas e direcionadas às necessidades clínicas do paciente, prevenindo disfunções neuropsicomotoras futuras e promovendo um desenvolvimento próximo aos padrões típicos infantis. Conclui-se através do estudo que o fisioterapeuta atuante na Unidade de Terapia Intensiva Neonatal, atua com foco central em evitar futuras disfunções neuropsicomotoras, através de estratégias de estimulações, para garantir uma evolução próxima a padrões típicos dos marcos do desenvolvimento infantil.
Analisis Kondisi Isolasi Pada Station Service Transformer (SST)
Authors: Rachmat Sutjipto  , Harrij Mukti K  , Kharisma Eka Dzulfiqar
Published: July 2024

There is an identified oil leak in SST Unit 1 at Paiton Power Plant, discovered after a fault indicator in Central Control Room. Visual inspection revealed that the gasket seal on the fastening bolts was damaged due to the seal reaching its lifetime limit. Continuous oil leaks degrade the transformer's oil, reducing its volume and impairing the transformer's cooling performance. The research aims to evaluate the insulation condition of the SST transformer before and after replacing the damaged gasket seal (repacking). This evaluation ensures the transformer's optimal performance and reliability by preventing potential failures caused by degraded insulation. The research employs a quantitative approach, using various tests to assess the insulation resistance of the transformer, including the Polarization Index (PI), Tangent Delta, and Breakdown Voltage tests. Data were collected from technical assessments and measurements conducted on-site at PT. PLN Nusantara Power (PLN NP). The comparison of data before and after repacking indicated significant improvements in the insulation condition of the SST transformer. All test results—PI, Tangent Delta, and Breakdown Voltage—met the standards post-repacking, showing better performance than before. Specifically, the Polarization Index and Tangent Delta values improved substantially, aligning with the IEEE C57.152-2013 standard, and the Breakdown Voltage met the IEC 60156-95 standard. The findings suggest that timely maintenance, such as gasket seal replacement, is crucial for maintaining the insulation quality and overall performance of transformers. Regular inspections and adherence to testing standards can prevent operational failures and extend the lifespan of critical electrical equipment.
Evaluasi Kinerja Sistem Proteksi Penyulang Trawas PT. PLN (PERSERO) ULP Pandaan
Authors: Satria Luthfi Hermawan  , Hilman Rangga Nugraha Hermawan  , Priya Surya Harijanto  , Ahmad Hermawan
Published: July 2024

The primary objective of this research was to minimize disruptions in the feeder at ULP Pandaan by analyzing the coordination between recloser outgoing and incoming feeders. This study addressed the frequent issue of recloser trips, which caused instability in power supply. The purpose of this research was to provide conclusions and solutions to mitigate these disruptions. The methodology involved a detailed analysis of OCR (Over Current Relay) settings for protective devices on Trawas feeder. This included measurements of primary current settings and TMS (Time Multiplier Setting) values using both standard inverse and normal inverse configurations. Specific settings, such as 25518 A for the Trawas Recloser primary current and a TMS of 0.07, were determined to yield optimal performance. Additional settings for the Outgoing CB (Circuit Breaker) (357061 A, TMS 0.04) and the Incoming CB (181865 A, TMS 1.0) were also established. The important findings revealed that these settings significantly enhanced the reliability of the protective devices, ensuring better coordination between the recloser and CB systems. The implications of this research were substantial, as the optimized settings were expected to reduce the frequency and impact of feeder disruptions. This improvement in system reliability directly benefited both the electricity provider, PT. PLN (Persert), and the consumers by providing a more stable and efficient power supply. In conclusion, this study offered a comprehensive analysis and practical solutions for enhancing the protection system's performance on the Trawas feeder, which could be applied to similar electrical distribution networks to achieve better stability and reliability.
Application of the FISH method and high-density SNP arrays to assess genetic changes in neuroblastoma—research by one institute
Authors: Winnicka Dorota , Skowera Paulina , Stelmach Magdalena , Styka Borys , Lejman Monika
Published: July 2024

Neuroblastoma is the most common extracranial solid tumor in children. Amplification of the MYCN gene has been observed in approximately 20%–30% of tumors. It is strongly correlated with advanced-stage disease, rapid tumor progression, resistance to chemotherapy and poor outcomes independent of patient age and stage of advanced disease. MYCN amplification identifies high-risk patients. To assess neuroblastoma tumors with MYCN amplification we used paraffin-embedded tissue sections in 57 patients and intraoperative tumor imprints in 10 patients by fluorescence in situ hybridization (FISH). Positive results for MYCN amplification have been observed in twelve patients’ paraffin-embedded tissue sections and in three patients’ intraoperative tumor imprints, which represents 22.4% of all patients tested in the analysis. Fluorescence in situ hybridization is a highly sensitive and useful technique for detecting MYCN amplification on paraffin-embedded tissue sections of neuroblastoma tumors and intraoperative tumor imprints thus facilitating therapeutic decisions based on the presence or absence of this important biologic marker. The presence of structural changes, regardless of MYCN gene amplification status, influences the clinical behavior of neuroblastoma. High-Density SNP Arrays have emerged as the perfect tools for detecting these changes due to their exceptional accuracy, sensitivity and ability to analyze copy number and allele information. Consequently, they are proven to be highly valuable in the genomic diagnosis of immature neuroectodermal tumors.
Weed resistance prediction: a random forest analysis based on field histories
Authors: Lepke Janin , Herrmann Johannes , Remy Nicolas , Beffa Roland , Richter Otto
Published: July 2024

Herbicide resistance has become a major issue in recent decades. Because diagnostics is still expensive, prediction models are helping to assess risks of resistance evolution. In this paper the influence of weed management on the evolution of resistance of the grass Alopecurus myosuroides Huds to ALS-inhibitors is investigated based on field history data from two regions, Hohenlohe in Germany and Champagne in France respectively. Champagne data also comprise information on Lolium spp. Using a random forest method variable importance and performance measures were obtained for a large number of single analyses allowing for a statistical analysis of the four performance measures, type I error, type II error, AUC and accuracy. It could be shown that acceptable predictions can be obtained for training data from Hohenlohe applied to Champagne and vice versa. It turned out that in nearly all analyses false negative classifications are more frequent than false positive classifications. Based on a combined training set of A.myosuroides samples from Hohenlohe and Champagne resistance status of Lolium spp. from the Champagne dataset can be predicted with a good accuracy. This suggest that resistance evolution to ALS-inhibitors of the two grasses are closely related. This work is a first step to set a simple herbicide resistance prediction tool to the users based on field history weed management data.
Utilization of orange peel waste for sustainable amino acid production by Corynebacterium glutamicum
Authors: Junker Nora , Sariyar Akbulut Berna , Wendisch Volker F.
Published: July 2024

Oranges are the most processed fruit in the world–it is therefore apparent that the industrial production of orange juice generates large quantities of orange peel as a by-product. Unfortunately, the management of the orange peel waste leads to economic and environmental problems. Meanwhile, the use of sustainable raw materials for the production of bulk chemicals, such as amino acids, is becoming increasingly attractive. To address both issues, this study focused on the use of orange peel waste as a raw material for media preparation for the production of amino acids by engineered Corynebacterium glutamicum. C. glutamicum grew on pure orange peel hydrolysate (OPH) and growth was enhanced by the addition of a nitrogen source and a pH buffer. Inhibitory effects by the combination of high concentrations of OPH, (NH4)2SO4, and MOPS buffer in the wild-type strain (WT), were overcome in the tyrosine-producing engineered C. glutamicum strain AROM3. Genetic modifications that we identified to allow for improved growth rates under these conditions included the deletions of the vanillin dehydrogenase gene vdh, the ʟ-lactate dehydrogenase gene ldhA and the 19 genes comprising cluster cg2663-cg2686. A growth inhibiting compound present in high concentrations in the OPH is 5-(hydroxymethyl)furfural (HMF). We identified vdh as being primarily responsible for the oxidation of HMF to its acid 5-hydroxymethyl-2-furancarboxylic acid (HMFCA), as the formation of HMFCA was reduced by 97% upon deletion of vdh in C. glutamicum WT. In addition, we showed that growth limitations could be overcome by adjusting the media preparation, using a combination of cheap ammonia water and KOH for pH neutralization after acidic hydrolysis. Overall, we developed a sustainable medium based on orange peel waste for the cultivation of C. glutamicum and demonstrated the successful production of the exemplary amino acids ʟ-arginine, ʟ-lysine, ʟ-serine, ʟ-valine and ʟ-tyrosine.
The prevalence of gestational diabetes among underweight and normal weight women worldwide: a scoping review
Authors: Gitlin Emily S. , Demetres Michelle , Vaidyanathan Arthi , Palmer Nicole , Lee Hannah , Loureiro Sabrina , Radwan Eman , Tuschman Abigail , Mathad Jyoti , Chebrolu Puja
Published: July 2024

Background

Gestational diabetes (GDM) affects nearly 15% of pregnancies worldwide and is increasing globally. While this growth is thought to be primarily from overweight and obesity, normal and underweight women are affected as well, particularly in low and middle-income countries. However, GDM in non-overweight women remains understudied. Thus, we examined the prevalence among normal and underweight women globally.

Methods

A comprehensive literature search was performed in Ovid MEDLINE, Ovid EMBASE, and The Cochrane Library. Studies retrieved were screened for eligibility against predefined inclusion/exclusion criteria. Prevalence of GDM among women with normal and underweight body mass index (BMI) was extracted, and average prevalence was calculated globally, by World Health Organization region, and by country. Pregnancy outcomes were described when available.

Results

A total of 145 studies were included. The average global prevalence of GDM among non-overweight women (BMI <25 kg/m2) was 7.3% and among underweight women (BMI <18.5 kg/m2) was 5.0%. GDM prevalence in non-overweight women was highest in Asia (average 12.1%) and lowest in the African region (0.7%). The countries with the highest prevalence were Vietnam (21.1%), Finland (19.8%), Poland (19.3%), Bangladesh (18.65%), and China (17.7%). The average global prevalence of large for gestational age infants (LGA) born to non-overweight women with GDM was 9.9%, which is lower than the average prevalence in the general population with GDM (14%).

Conclusion

GDM is more common than previously recognized in non-overweight women, particularly in Asia, but also in European countries. Non-overweight women with GDM had lower prevalence of LGA babies compared to prior reported prevalence in all women with GDM, though data on pregnancy outcomes was limited. These findings challenge guidelines that recommend restriction of weight gain for GDM management. Further research on the pathophysiology and complications of GDM in women who are not overweight should be urgently conducted to inform appropriate management guidelines and support optimal pregnancy outcomes.