bluuebunny/crossref_metadata_2025 huggingface dataset:
A COMPETÊNCIA PARA TOCAR O BAILE:(IN)CONSTITUCIONALIDADE DAS NORMAS ESTADUAIS QUE INCUMBEM A POLÍCIA CIVIL DE AUTORIZAR E LICENCIAR EVENTOS
Authors: Pereira Gomes Mateus , De Sousa Pequeno Júnior José Eronildes
Published: December 2022

O trabalho tem como problema a seguinte questão “são constitucionais as normas estaduais que atribuem à Polícia Civil a competência para autorizar e licenciar eventos como shows, feiras e outros semelhantes?”. O objetivo geral é investigar a constitucionalidade de tais normas e, em caso de serem inconstitucionais, analisar seus reflexos na liberdade individual. O método utilizado na presente pesquisa foi o dedutivo, seguindo por uma abordagem qualitativa para explorar, descrever e explicar o problema, para obtenção de dados foi utilizado o instrumental da pesquisa bibliográfica. Sustentado, via de regra, em dados obtidos de documentação indireta, exceção feita às pesquisas jurisprudenciais em que a investigação documental foi direita. Pode-se dizer, de forma sintética, que o trabalho concluiu serem inconstitucionais as normas que atribuem competência à Polícia Civil para autorizar e licenciar eventos, tendo tal inconstitucionalidade reflexo na liberdade individual que se pauta pelo princípio da legalidade e na liberdade empresarial ancorada na livre iniciativa, e ainda na segurança jurídica que assegura ambas liberdades.
O HABEAS CORPUS E A PUNIÇÃO DISCIPLINAR MILITAR: CONSIDERAÇÕES E POSSIBILIDADES JURISPRUDENCIAIS
Authors: Dantas Júnior João Fabrício
Published: December 2022

A pesquisa lida com a limitação constitucional ao habeas corpus diante de restrição à liberdade de locomoção imposta por punição disciplinar militar. Exceção ao remédio constitucional, tal previsão traga para si nuances igualmente constitucionais da Administração Pública Militar e ainda da Justiça Militar. Dentre elas, aquela que sustenta a exceção objeto do estudo: a hierarquia militar. O habeas corpus no seio administrativo militar, assim, enfraquecido, por primeiro, pela possibilidade de manejo de prisão administrativa cujo mérito é blindado à Jurisdição, também é reforçado pela restrição ao remédio constitucional, esse objeto da pesquisa. Na busca sobre tais limitações, os ditames do Princípio da Legalidade, jungido à Administração Pública, poderão dar luz sobre o manuseio jurisdicional dos motivos de tal prisão; ainda, saber como seria regida a restrição ao habeas corpus diante de uma eventual prisão administrativo-militar de um civil; por último, como tal restrição, de cunho constitucional, atingiria o conteúdo normativo da dignidade da pessoa humana. A restrição a tal remédio constitucional, assim, motiva a pesquisa para a construção desse específico regime jurídico. Para a pesquisa, utiliza-se de farta fontes doutrinárias, posições jurisdicionais e legais que, através de exercício argumentativo dedutivo, encontram soluções hermenêuticas ao referido objeto, tanto adotando seu caráter hierárquico superior como, ainda, utilizando-o para interpretar o sistema jurídico e as eventuais exceções de caráter constitucional aos direitos e às garantias que impõem e protegem a liberdade ambulatória.
ANÁLISE DOS TERMOS DE REFERÊNCIA DOS PREGÕES ELETRÔNICOS REALIZADOS PELO MUNICÍPIO DE JAGUARIBE DO ANO DE 2021 À LUZ DO DECRETO FEDERAL 10.024/2019: UM ESTUDO DE CASO
Authors: Soares Leilane Kércia Barreto Soares , Santana da Silva Heibe , Batista Martins Thobias
Published: December 2022

Este trabalho faz um estudo sobre os termos de referência dos pregões eletrônicos realizados pelo município de Jaguaribe à luz do Decreto Federal 10.024/2019, avaliando as características e os elementos essenciais recomendados pela legislação, verificando os itens presentes e ausentes. Para esse propósito foram selecionados os editais de licitações do ano de 2021 no website do Tribunal de Contas do Estado do Ceará (TCE/CE), obtendo 31 editais. Dentre os principais resultados observados foi que a maior parte das exigências do Decreto Federal, artigo 3°, inciso XI, não são atendidos. Sobretudo, referentes a alínea d), referente a relação dos documentos essenciais à verificação da qualificação técnica e econômico-financeira, se necessária; a alínea f), o prazo para execução do contrato; e a alínea g) as sanções previstas de forma objetiva, suficiente e clara. Ou seja, houve uma falha grave de planejamento e a ausência desses elementos gera prejuízos na execução contratual, causando danos na entrega final do objeto. A falta desses elementos deixa a cargo da pregoeira a reponsabilidade de definir, no edital, essas informações que deveriam estar presentes no termo de referência, pois esta não possui conhecimento adequado para definir os elementos. Esses problemas poderiam ter sido sanados com a utilização de chek-list, ou com a padronização de um termo de referência, simplificando para os responsáveis por sua elaboração. Outra questão urgente é a capitação dos gestores e funcionários públicos responsáveis pelo planejamento e pela elaboração dos termos de referência.
ANÁLISE DAS POLÍTICAS PÚBLICAS NACIONAIS VOLTADAS À INSERÇÃO DA PESSOA COM TRISSOMIA 21 NO MERCADO DE TRABALHO
Authors: Lopes Nascimento Jhule Michele , Rocha Renata Rodrigues de Castro
Published: December 2022

O presente trabalho buscou verificar as políticas públicas que tutelam a inserção da pessoa com Trissomia 21 no mercado de trabalho. Diante do tema abordado, buscou-se descrever a condição da pessoa com trissomia 21, pesquisou-se a legislação vigente no ordenamento jurídico pátrio e seus impactos nos direitos das pessoas com Trissomia 21 e analisou-se as Políticas Públicas voltadas à inserção no mercado de trabalho para pessoas com Trissomia 21. Dessa forma, pesquisou-se bibliografias, leis, documentos jurídicos e históricos que amparam a implementação de medidas inclusivas às pessoas com Trissomia 21 (Síndrome de Down) na seara trabalhista, analisou-se, ainda, a efetividade e eficácia das medidas implementadas. Pode-se perceber, conforme os dados encontrados, a inexistência de medidas especificamente voltadas para a inclusão da pessoa com Trissomia 21, quanto pessoa com deficiência de natureza intelectual, no âmbito do trabalho.
EMPRESA INDIVIDUAL DE RESPONSABILIDADE LIMITADA: CRÍTICAS E DESENVOLVIMENTO DA SOCIEDADE LIMITADA UNIPESSOAL
Authors: Mezadri Pinheiro Êmily , Martins Silva Rocha Jakeline
Published: December 2022

O presente artigo se propõe a dissertar acerca dos fundamentos para a instituição da Empresa Individual de Responsabilidade Limitada, perpassando pelas legislações estrangeiras e requisitos necessários, sendo citadas, ainda, as críticas doutrinárias e jurisprudenciais tecidas a esta. Após, será apresentado o desenvolvimento e avanço da Sociedade Limitada Unipessoal em legislação nacional, com posterior análise comparativa no que concerne a utilização e aplicabilidade de tais institutos por empresários individuais, mediante dados estatísticos fornecidos por juntas comerciais dos estados do Espírito Santo e Rio de Janeiro.
ANALISIS DEBIT BANJIR RANCANGAN DENGAN METODE HIDROGRAF SATUAN SINTETIS NAKAYASU DI SUB DAS KEDUANG (Analysis of planned flood discharge using the Nakayasu synthetic unit hydrograph in Keduang Sub Watershed)
Authors:   Balai Penerapan Standar Instrumen Lingkungan Hidup dan Kehutanan Solo, Nugrahanto Esa , Suprayogi Slamet , Hadi Mohammad , Rahmadwiati Rissa ,   Program Studi MPPDAS Fakultas Geografi Universitas Gadjah Mad,   Program Studi Pengelolaan Hutan Fakultas Pertanian Universitas Sebelas Maret
Published: December 2022

Keduang Sub Watershed was an area prone to flooding. This happens because of the varied land cover followed by low forest cover. This circumstance leads to an increase in runoff which has the potential to become flooded. This study aims to analyze the planned flood discharge in the Keduang Sub Watershed with several return periods. The study was conducted using secondary data analysis in 2007-2018. Rainfall analysis was performed by several methods, namely normal method, normal log, pearson III log, and gumbel and tested with chi square and kolmogorov smirnov tests. Planned flood discharge analysis was using the Nakayasu synthetic unit hydrograph method. Results showed that the rainfall analysis chosen is normal method. The planned flood discharge obtained that the maximum discharge of the 2-yearly return period was 1,375.20 m3/s, the 5-yearly return period was 1,724.92 m3/s, the 10-yearly return period was 1,908.10 m3/s, the 20-yearly return period was 2,057.97 m3/s, the 25-yearly return period was 2,087 m3/s, the 50-yearly return period of 2,228.67 m3/s, the 100-yearly return period of 2,345.24 m3/s, and the 1000-yearly return period of 2,661.64 m3/s. Flood discharges are increasing in the larger return period, and the largest flood discharge occurred in the 1000-yearly return period. The results of this study are expected to be used in watershed planning and management for flood disaster mitigation in Keduang Sub Watershed.
Pathogenicity of SARS-CoV-2 Omicron BA.5 and BE.1 Variants in Syrian Hamsters and hACE2-transgenic Mmice
Authors: Dolzhikova Inna , Grousova Daria , Zorkov Ilia , Kovyrshina Anna , Iliukhina Anna , Shelkov Artem , Botikov Andrei , Kuznetsova Nadezhda , Pochtovyi Andrei , Demyashkin Grigory , Suslova Alisa , Nedorubov Andrei , Komissarov Andrei , Danilenko Daria , Lioznov Dmitry , Tukhvatulin Amir , Shcheblyakov Dmitry , Gushchin Vladimir , Logunov Denis , Gintsburg Alexander
Published: December 2022

A new variant of the SARS-CoV-2 Omicron BA.5 virus has displaced all previous variants of the virus around the world. Preliminary assessment of the effectiveness of drugs for the prevention and treatment of COVID-19 requires the availability of infection models in animals. In this study, we characterize the infection model SARS-CoV-2 Omicron BA.5 and its progeny sublineage BE.1 in hACE2-transgenic mice and in Syrian hamsters. Both sublineages turned out to be pathogenic for animals – the challenged animals showed weight loss, a high level of viral load and acute inflammation in the lungs. Part of BA.5-infected mice died after virus challenge, indicating that this virus variant is more pathogenic than the previous BA.1 variant but less pathogenic than Wuhan variant.
Direct Implications between Prenatal Alcohol Consumption and Gut Microbiome in the Neurodevelopment of Mice Offspring – Focusing On Foetal Alcoholic Spectrum Disorders
Authors: Pedroso-Roussado Cristiano , Guppy Fergus , Bowler Lucas , Inacio Joao
Published: December 2022

Disorders associated with substance abuse are a major public health crisis with few treatment options. According to World Health Organization (WHO) ethanol is the most widely used drug in the world, and it represents a risk factor for the advent of disease, disability, and eventually death. Foetal Alcoholic Spectrum Disorders (FASD) is a diagnostic term to describe the range of effects that can occur in an individual whose mother drank alcohol during pregnancy. These effects encompass both physical, mental, behavioural and further lifelong disabilities. Besides, ethanol can harm the gut microbiota. Gut microbiome is firstly acquired from the mother and it is crucial for intestinal homeostasis during hosts’ lifetime. It is responsible for producing metabolites that benefits and protects the host from harm microbial colonization. Knowledge about the interactions between human gut microbes and the developing nervous system is still scarce. Nevertheless, animal models have shown that gut bacteria and microbial metabolites are strongly associated with Central Nervous System (CNS) homeostasis. Endotoxins such as Lipopolysaccharides (LPS) are hypothesized to have a major role in neurodegeneration, however, conclusions must be taken with care due to differences in sensitivity between humans and mice. In this review we focus on the role of gut microbiota on the neurodevelopment of mice when ethanol consumption is one of the major stressors during prenatal period. We detail the range of the endotoxin hypothesis in describing endotoxins’ contribution to neurodegeneration and the influence that kynurenine pathway has on the process.
SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-To-Cell Fusion via Activation of Srebp-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2
Authors: Essalmani Rachid , Andreo Ursula , Evagelidis Alexandra , Le Dévéhat Maïlys , Pereira Ramos Oscar Henrique , Fruchart Gaillard Carole , Susan-Resiga Delia , Cohen Eric A. , Seidah Nabil G.
Published: December 2022

Proprotein convertases activate various envelope glycoproteins and participate in cellular entry of many viruses. We recently showed that the convertase furin is critical for the infectivity of SARS-CoV-2. This study investigated the implication of the two cholesterol-regulating convertases SKI-1 and PCSK9 in SARS-CoV-2 entry. We used cell-to-cell fusion assays in HeLa cells and pseudoparticle entry into Calu-3 cells. SKI-1 increases cell-to-cell fusion by enhancing the activation of SREBP-2, whereas PCSK9 reduces cell-to-cell fusion by promoting the cellular degradation of ACE2. Metalloprotease activation is sensitive to enhanced cholesterol levels resulting from SKI-1-activated SREBP-2 that leads to enhanced S2’ formation. However, high metalloprotease activity results in S2’ shedding into a new C-terminal fragment (S2”), leading to reduced cell-to-cell fusion. Indeed, S-mutants that increase S2’’ formation, abolish S2’ and cell-to-cell fusion, as well as pseudoparticles entry, indicating that the formation of S2’’ prevents SARS-CoV-2 cell-to-cell fusion and entry. We next demonstrated that PCSK9 enhanced the cellular degradation of ACE2, thereby reducing cell-to-cell fusion. However, different from the LDLR, a canonical target of PCSK9, the C-terminal CHRD domain of PCSK9 is dispensable for the PCSK9-induced degradation of ACE2. Molecular modeling suggested binding of ACE2 to the Pro/Catalytic domains of mature PCSK9. Thus, both cholesterol-regulating convertases SKI-1 and PCSK9 can modulate SARS-CoV-2 entry via two independent mechanisms.
High-quality Reconstruction of Disease Mechanisms: Planning, Development and Maintenance
Authors: Mazein Alexander , Acencio Marcio Luis , Balaur Irina , Rougny Adrien , Welter Danielle , Niarakis Anna , Ramirez Ardila Diana , Dogrusoz Ugur , Gawron Piotr , Satagopam Venkata , Gu Wei , Kremer Andreas , Schneider Reinhard , Ostaszewski Marek
Published: December 2022

As a conceptual model of disease mechanisms, a disease map integrates available knowledge and is applied for data interpretation, predictions and hypothesis generation. It is possible to model disease mechanisms on different levels of granularity and adjust the approach to the goals of a particular project. This rich environment together with requirements for high-quality network reconstruction makes it challenging for new curators and groups to be quickly introduced to the development methods. In this review, we offer a step-by-step guide for developing a disease map within its mainstream pipeline that involves using the CellDesigner tool for creating and editing diagrams and the MINERVA Platform for online visualisation and exploration. We also describe how the Neo4j graph database environment can be used for managing and querying efficiently such a resource. For assessing the interoperability and reproducibility we apply FAIR principles.
Impact of Drought on Maize Yield and Exploration of In-Situ Maize Crop Genetic Resources for Drought Tolerance.
Authors: SINGH G MAHENDRA , Gosavi Gokul , S Srinathareddy , Patel Shiv Shankar , Solanki Pawan Singh , Zhang Feng , Xu Jianchu , Mishra V K , Sharma Sandeep
Published: December 2022

To meet an ever global population's food demand, crop yields must be sustained and increased. Drought, which is getting harsher as a result of global warming, is largely impeding the agricultural productivity. Maize is widely used as food and animal feed in many regions of the world, but its yields are largely effected by drought and heat stress. Historical data on climate change predicts that drought and heat stress becoming major threat for maize cultivation in coming years, which will have huge impact on food security of the world especially in Africa and Asia. Thus there is an immense necessary to develop drought tolerant and climate resilient maize to feed the predicted population of the world. Availability and accessibility of crop genetic resources plays a huge role in development of drought-tolerant maize cultivars. A huge genetic resources of maize, including its landraces and crop wild relatives (CWR) have been reported naturally and many of them have stored in National and International gene banks globally. Conventional breeding methods have been tremendously increased maize yields, but these methods frequently fall short of achieving the demand for improved drought stress resistance. In this article, we have briefly discussed about impact of climate variability on crop production, maize yield losses due to drought, drought tolerance in maize landraces and CWR, and origin and evolution of Mexican landraces. This information may help in utilization of these potential resources in various pre-breeding programs.
Lung-Heart Toxicity in a Randomized Clinical Trial of Hypofractionated Image Guided Radiation Therapy for Breast Cancer
Authors: Van Parijs Hilde , Cecilia-Joseph Elsa , Gorobets Olena , Storme Guy , Adriaenssens Nele , Heyndrickx Benedicte , Verschraegen Claire , Nguyen Nam P. , Ridder Mark De , Vinh-Hung Vincent
Published: December 2022

TomoBreast hypothesized that hypofractionated 15 fractions/3 weeks image-guided radiation therapy (H-IGRT) can reduce lung-heart toxicity, as compared with normofractionated 25-33 fractions/5-7 weeks conventional radiation therapy (CRT). 123 women with stage I-II operated breast cancer were randomized to receive CRT (N=64) or H-IGRT (N=59). The primary endpoint used a four-items measure of the time to 10% alteration in any of patient self-reported measure, physician clinical evaluation, echocardiography or lung function tests, analyzed by intention-to-treat without exclusion. Results found comparable survivals, but H-IGRT significantly reduced the toxicity measured by lung diffusion capacity and alveolar volume as compared with CRT, G1 in 53% (31/59) versus 72% (44/61) patients, P=0.006; G2, 29% versus 48%, P=0.020. H-IGRT significantly reduced the risk of composite cardio-pulmonary alteration at 5 years, 10.2% versus 26.7%, P=0.024. In conclusion, TomoBreast is a proof-of-concept that image-guided radiation-therapy can improve the overall balance of lung-heart outcomes in breast cancer adjuvant therapy. Furthermore, the significance of the findings supports the efficacy of a small trial size design, which can be critical when clinical research resources are limited.
Association Between Estimated Cardiorespiratory Fitness and Abnormal Glucose Risk: A Cohort Study
Authors: Sloan Robert A , Kim Youngdeok , Kenyon Jonathan , Scarzanella Marco Visentini , Sawada Susumu S , Sui Xuemei , Lee I-Min , Myers Jonathan N , Lavie Carl J
Published: December 2022

Background. Cardiorespiratory fitness (CRF) is a predictor of chronic disease that is impractical to routinely measure in primary care settings. We used a new estimated cardiorespiratory fitness (eCRF) algorithm that uses information routinely documented in electronic health care records to predict abnormal blood glucose incidence. Methods: Participants were adults (17.8% female) 20-81 years old at baseline from the Aerobics Center Longitudinal Study between 1979 and 2006. eCRF was based on sex, age, body mass index, resting heart rate, resting blood pressure, and smoking status. CRF was measured by maximal treadmill testing. Cox proportional hazards regression models were established using eCRF and CRF as independent variables predicting the abnormal blood glucose incidence while adjusting for covariates. Results: Of 8,602 participants at risk at baseline, 3,580 (41.6%) developed abnormal blood glucose during an average of 4.9 years follow-up. The average eCRF of 12.03 ± 1.75 METs was equivalent to the CRF of 12.15 ± 2.40 METs within the 10% equivalence limit. In fully adjusted models, the estimated risks were the same (HRs = 0.96), eCRF (95% CIs = 0.93−0.99), and CRF (95% CI of 0.94−0.98). Each 1-MET increase was associated with a 4% reduced risk. Conclusion: Higher eCRF is associated with a lower risk of abnormal glucose. eCRF can be a vital sign used for research and prevention.
rMELEISH:A Novel Recombinant Multiepitope-Based Protein Applied to The Serodiagnosis of Both Canine and Human Visceral Leishmaniasis
Authors: Dias Daniel Silva , Machado Juliana Martins , Ribeiro Patriciia Aparecida Fernandes , Machado Amanda Sanchez , Ramos Fernanda Fonseca , Nogueira Lais Moreira , Gonçalves Ana Alice Maia , Ramos Luana de Sousa , Gandra Isadora Braga , Coutinho Flaviane Silva , Santos Michelli , Silva Jonatas Oliveira , Chávez-Fumagalli3 Miguel Angel , Teixeira-Neto Rafael Gonçalves , Chaves Ana Thereza , Campos-da-Paz Mariana , Souza Amanda A , Giunchetti Rodolfo Cordeiro , Freitas Sonia Maria , Lyon Sandra , De Magalhães-Soares Danielle Ferreira , Da Silveira Julia Angelica Gonçalves , Silva Eduardo Sergio , Coelho Eduardo Antonio Ferraz , Galdino Alexsandro Sobreira
Published: December 2022

Background: Visceral leishmaniasis (VL) is s critical public health problem in over ninety countries. The control measures adopted in Brazil have been insufficient when it comes to preventing the spread of this neglected disease. In this context, a precise diagnosis of VL in dogs and humans could help to reduce the number of cases of this disease. Distinct studies for the diagnosis of VL have used single recombinant proteins in serological assays; however, results have been variable, mainly in the sensitivity of the antigens. The development of multiepitope-based proteins could be relevant in solving such a problem. Methods: A chimeric protein (rMELEISH) was constructed based on amino acid sequences from kinesin 39 (k39), alpha-tubulin, and heat shock proteins HSP70 and HSP 83.1, and tested in ELISA for the detection of L. infantum infection in humans and dogs. Results: rMELEISH was able to discriminate between VL cases and cross-reactive diseases and healthy samples, with sensitivity and specificity values of 100% as compared to the use of a soluble Leishmania antigenic extract (SLA). Conclusions: Preliminary data suggest that the rMELEISH protein presents a potential to be tested in future studies against a larger serological panel for the diagnosis of canine and human VL.
A Classification of Digital Platforms Applied to the Governance of Smart Cities
Authors: Ferreira Lucas Carvalho , Makiya Ieda Kanashiro , Cesar Francisco Giocondo
Published: December 2022

This research seeks to understand the impact of digital platforms on the governance of smart cities. It uses the Scaffold of Popular Participation to classify digital platforms and better understand participatory governance in cities, its benefits and complications, correlating them with the SDGs of the 2030 Agenda. It was also possible to list points of attention for the development of digitization in the public sector, including in Brazil. It concluded that the digitization of public services is in progress, pressured by the civil body for greater transparency and participation. In addition, the platforms must be guided by civil inclusion in the discussion of public policies, by the training of intelligent citizens and by sustainable guidelines that guide the themes addressed. In contrast, platforms can also facilitate deception and popular manipulation, which represents a high risk if used for this purpose.
Risks in Major Cryptocurrency Markets: Modelling Double Long Memory and Structural Breaks
Authors: Jiang Zhuhua , Mensi Walid , Yoon Seong-Min
Published: December 2022

This study estimates the effects of double long memory and structural breaks on the persistence level of six major cryptocurrency markets. We apply the Bai and Perron’s structural break test, Inclán and Tiao’s iterated cumulative sum of squares (ICSS) algorithm, and the fractionally integrated generalized autoregressive conditional heteroscedasticity (FIGARCH) model with different distributions. The results show that long memory and structural breaks characterize the conditional volatility of cryptocurrency markets and confirm our hypothesis that ignoring structural breaks leads to an underestimation of the persistence of volatility modelling. The ARFIMA-FIGARCH model with structural breaks and a skewed Student–t distribution fits the cryptocurrency market’s price dynamics well.
Current Metabolic Engineering Strategies for Photosynthetic Bioproduction in Cyanobacteria
Authors: Satta Alessandro , Esquirol Lygie , Ebert Birgitta E.
Published: December 2022

Cyanobacteria are photosynthetic microorganisms capable of using solar energy to convert CO2 and H2O into O2 and energy-rich organic compounds, thus enabling sustainable production of a wide range of bio-products. More and more strains of cyanobacteria are identified that show great promise as cell platforms for the generation of bioproducts. However, strain development is still required to optimize their biosynthesis and increase titers for industrial applications. This review describes the most well-known and newest most promising strains available to the community and gives an overview of current cyanobacterial biotechnology and the latest innovative strategies used for engineering cyanobacteria. We summarize advanced synthetic biology tools for modulating gene expression and their use in metabolic pathway engineering to increase the production of value-added compounds, such as terpenoids, fatty acids, and sugars, to provide a go-to source for scientists starting research in cyanobacterial metabolic engineering.
Diversity, Distribution and Development of Hyperparasitic Microsporidia in Gregarines within One Super-host
Authors: Frolova Ekaterina V. , Paskerova Gita G. , Smirnov Alexey V. , Nassonova Elena S.
Published: December 2022

Metchnikovellids (Microsporidia: Metchnikovellida) are poorly studied hyperparasitic micro-sporidia that live in gregarines inhabiting the intestines of marine invertebrates, mostly poly-chaetes. Our recent studies showed that the diversity of the metchnikovellids might be signifi-cantly higher than previously thought, even within a single host. Four species of metchnikovellids were found in the gregarines inhabiting the gut of the polychaete Pygospio elegans from littoral populations of the White and Barents Seas: the eugregarine Polyrhabdina pygospionis is the host for Metchnikovella incurvata and M. spiralis, while the archigregarine Selenidium pygospionis is the host for M. dogieli and M. dobrovolskiji. The most common species in the White Sea is M. in-curvata, while M. dobrovolskiji prevails in the Barents Sea. The gregarines within a single worm could be infected with different metchnikovellid species. However, co-infection of one and the same gregarine with several species of metchnikovellids has never been observed. The difference in prevalence and intensity of metchnikovellid invasion apparently depends on the features of the life cycle and on the development strategies of individual species.
Proyecto STEM sobre la generación de energía eléctrica en el río Amajac usando turbinas
Authors: Suárez Rodríguez Carmen del Pilar , Martinez Ortiz Nicolas , Perez Santiago Angel Ossiel , Castillo Meraz Raúl
Published: December 2022

La presente investigación tiene como objetivo identificar la factibilidad de obtener energía eléctrica de una corriente de agua para cubrir necesidades básicas de habitantes de comunidades rurales y remotas de Tamazunchale, San Luis Potosí, México, en la ribera del río Amajac. El método de solución de problemas fue el círculo de Deming. Se llevó a cabo una revisión bibliográfica de las turbinas hidráulicas existentes en el mercado y se identificaron las variables relacionadas con la generación de energía. Asimismo, se identificó cuál es la turbina más adecuada y el sistema de mayor eficiencia para las condiciones de esa parte de México y se recolectaron datos en tres localidades diferentes (Tlapexhuaca Tacial, Taman y Vega Larga) utilizando el método del flotador para conocer el caudal y cálculos respectivos. Se encontró que la localidad de Tlapexhuaca Tacial tiene la mayor velocidad de corriente de río con una energía cinética promedio de 3847 Joules, por lo que en trabajos futuros se trabajará en el diseño de la turbina óptima.
Métodos de remoción de metales en aguas para consumo humano: Una revisión
Authors: Zúñiga-Martínez Sebastián , Ibáñez-Hernández Oscar F. , Salas Plata-Mendoza Jorge A. , Flores-Tavizón Edith , Velázquez-Angulo Gilberto
Published: December 2022

La contaminación de las fuentes de agua naturales empleadas para el abastecimiento humano es una problemática en crecimiento alrededor del mundo, en especial por el aumento de sustancias tóxicas presentes en estas. Lo anterior conlleva a la evaluación de alternativas de tratamiento para la remoción de metales pesados. En el presente documento se recopiló información disponible en diferentes medios físicos y electrónicos en torno a los métodos empleados para la potabilización del agua y los costos asociados al volumen de agua procesada y/o porcentaje de contaminantes removidos. Con esto, se encontró que los métodos fisicoquímicos, por membranas, adsorbentes y electroquímicos, son los más empleados para la remoción de metales pesados en el agua potable, siendo los métodos fisicoquímicos los más económicos en su operación (0.0163 USD/m3) y los de membrana de ósmosis inversa los más costosos (0.3319 USD/m3). Además, estos costos están relacionados con la remoción de sustancias como As, Cr, Cd, Cu, Hg, Pb, Ni y de las cuales, se detectó al As y Pb como los más relevantes. Además, hay gran variedad de métodos que son aplicables a la potabilización del agua, sin embargo, la selección de estos debe ajustarse a la situación general de la fuente de agua existente, la legislación aplicable, las necesidades de la población y los recursos disponibles para su tratamiento.
Electrocoagulación de iones de metales pesados en aguas residuales: Una revisión
Authors: Rubí-Juárez Humberto , Soto Padilla Marisela Yadira , Domínguez-Acosta Miguel
Published: December 2022

La presencia de metales pesados en el agua para consumo humano tiene su origen en las actividades antropogénicas o en procesos naturales. Los seres humanos pueden estar expuestos a 23 de estos minerales que son tóxicos en dosis grandes o pequeñas y pueden afectar diversos órganos, desencadenar enfermedades como Parkinson y Alzheimer por acumulación progresiva o provocar cáncer. Los métodos de tratamiento pretenden abatir la concentración de metales pesados en matrices acuosas, al mismo tiempo que se manifiestan como una solución. La tecnología electroquímica denominada electrocoagulación ha sido usada con éxito para remover cadmio, cobre, cromo, manganeso, mercurio, níquel y cinc en el laboratorio sin descartar, aunque con menor frecuencia, la escala piloto. Se revisaron artículos sobre investigaciones en este tema desarrolladas entre 2015 y 2022 en diversos países y se concluye que electrocoagulación tiene el potencial para propiciar un uso exitoso en plantas de tratamiento pequeñas debido a sus ventajas, entre ellas que no requiere del suministro suplementario de algún compuesto químico en su concepción más básica, genera menor cantidad de lodos, la selección de los materiales electródicos y el acomodo dentro de la celda son relevantes para lograr resultados superiores y el costo energético razonable por cada metro cúbico de agua procesada.
Upaya Meningkatkan Motivasi Berwirausaha Berbasis Potensi Lokal pada Masyarakat Petani di Desa Sirnajaya Kabupaten Bogor, Jawa Barat
Authors: Irvansyah Adi , Hadiyanti Puji , Koeswantono Sri , Sasmita Karta
Published: December 2022

Saat ini pembangunan masyarakat desa memiliki perubahan paradigma mendasar, yaitu dari membangun desa menjadi desa membangun. Untuk mewujudkan desa membangun diperlukan peningkatan kapasitas sumber daya insani desa yaitu untuk menstimulan wirausaha masyarakat desa dibidang pertanian. Pengabdian kepada masyarakat ini dilakukan dalam rangka mencapai transformasi desa membangun yaitu melalui motivasi wirausaha para petani di pedesaan. Kegiatan pengabdian kepada masyarakat ini dilakukan dengan pendekatan transformative learning dengan metode sharing knowledge berupa diskusi dan pendampingan secara berkelanjutan. Pada kegiatan pengabdian kepada masyrakat yang dilakukan di desa Sirnajaya menghasilkan perubahan perilaku masyarakat petani, yang semula para petani hanya berorientasi menjadi buruh tani, saat ini para petani memiliki motivasi untuk bertansformasi menjadi pengusaha dibidang pertanian. Motivasi wirausaha kepada para petani dilakukan dengan memanfaatkan kelembagaan pedesaaan seperti BumDes dalam menyediakan dan memfasilitasi para petani untuk menjalankan wirausaha dan menjual produk pertaniannya. Melalui pola kemitraan dengan BumDes para petani menjadi lebih percaya diri untuk menjadi wirausaha dibidang pertanian dibandingkan menjadi buruh tani.Transformasi yang dimaksud dalam rangka mencapai keberdayaan masyarakat yang memiliki daya saing, daya saring dan daya adaptasi. Melalui kegiatan pengabdian kepada masyarakat ini, memberikan sumbangsih dalam pemberdayaan ekonomi masyarakat desa. Sehingga melalui kegiatan ini, tindak lanjut berikutnya ialah mengembangkan usaha pertanian kreatif dan innovatif untuk menghasilkan produk pertanian yang sesuai dengan permintaan pasar.
Penyuluhan Pengetahuan melalui Media Buku Saku dalam Menyosialisasikan Bahan Kimia Berbahaya pada Kosmetika di Lingkungan Kelurahan Jatinegara Kaum – Pulo Gadung – Jakarta Timur – DKI Jakarta
Authors: Ambarwati Neneng Siti Silfi , Armandari Mari Okatini , Hidajatulloh Audrey Febrina , Nabillah Naflah Lutfi
Published: December 2022

Keinginan untuk mempercantik diri dengan menggunakan kosmetik yang berlebihan menyebabkan masyarakat/ konsumen sering membuat kesalahan dalam memilih dan menggunakan kosmetik tanpa memperhatikan kondisi kulit dan kandungan bahan dasar kosmetik. Hal ini dapat menyebabkan berbagai masalah kelainan kulit karena kurangnya pengetahuan dalam pemilihan dan penggunaan kosmetik yang baik dan benar. Dalam hal ini maka diperlukannya penyuluhan untuk melindungi masyarakat dengan memberikan informasi yang benar, jelas dan jujur mengenai jaminan barang atau jasa kecantikan. Permasalahan mitra tersebut yang diangkat pada program pengabdian kepada masyarakat ini adalah pemberian penyuluan yan merupakan upaya preventif kepada masyarakat terkait bahan kimia berbahaya pada kosmetik dan legalitasnya. Hal ini dimaksudkan agar generaasi milenial dan ibu-ibu PKK Kelurahan Jatinegara Kaum - Kecamatan Pulo Gadung – Jakarta Timur – DKI Jakarta menjadi lebih bijak dalam memilih dan menggunakan kosmetik. Kegiatan pengabdian pada masyarakat ini dilaksanakan dengan menggunakan metode penyuluhan dengan presentasi, buku saku dan power point. Hasil dari program pengabdian kepada masyarakat ini adalah masyarakat Kelurahan Jatinegara Kaum - Kecamatan Pulo Gadung – Jakarta Timur – DKI Jakarta akan lebih berhati-hati dalam memilih dan menggunakan kosmetik yang baik dan aman, serta memperoleh pengetahuan tentang bahan kimia berbahaya dalam kosmetik yang selama ini mereka gunakan.
Pengaruh Formulasi Kulit Buah Kopi Arabika dan Umbi Bawang Dayak terhadap Mutu Seduhan Minuman Herbal Carcara
Authors: Hasni Dian , Muzaifa Murna , Nilda Cut , Harahap Risda Munarti Rusdi
Published: December 2022

Cascara merupakan suatu produk samping limbah kulit kopi yang dapat diolah menjadi minuman herbal. Cascara dan seduhannya berpotensi sebagai antioksidan alami karena mengandung metabolit sekunder seperti golongan polifenol. Secara organoleptik, seduhan cascara beraroma buah, dengan rasa asam yang segar dan ringan. Di sisi lain, umbi bawang dayak mengandung flavonoid dan berpotensi sebagai obat hipertensi, anti-inflamasi dan anti-diabetes. Namun rasanya yang cenderung pahit menyebabkan umbi bawang dayak sulit berkembang sebagai produk minuman herbal. Penelitian ini bertujuan untuk mengetahui pengaruh dari formulasi  cascara dan bawang dayak yang digunakan terhadap mutu seduhan minuman herbal yang dihasilkan. Penelitian ini menggunakan Rancangan Acak Kelompok dengan perlakuan formulasi cascara dan bawang dayak (K1= 100:0, K2= 80:20, K3= 60:40, K4= 40:60, K5= 20:80, K6= 0:100), dan diulang 4 kali. Hasil penelitian menunjukkan semakin besar proporsi cascara dalam formulasi minuman herbal celup, maka pH seduhannya cenderung semakin asam dan nilai total fenolnya semakin tinggi, warna teh yang semakin terang, rasa asam dan sepat yang semakin kuat dan pahit yang lemah. Panelis cenderung menyukai aroma dan rasa minuman herbal dengan proporsi cascara yang lebih besar sehingga formulasi K3 (60:40) menghasilkan minuman herbal dengan mutu terbaik. Formulasi K3 memiliki pH 4,34, total fenol 488,3 mg GAE/mL dan berdasarkan uji deskripsi, rasa sepat, rasa asam, dan rasa pahit berada dalam kisaran yang sama sehingga tidak ada rasa yang lebih dominan.
Pengaruh Ukuran Bulbil dan Komposisi Media Tanam terhadap Pertumbuhan dan Hasil Porang (Amorphophallus Muelleri Blume)
Authors: Saefudin Saefudin , Sakiroh Sakiroh , Wardiana Edi , Pranowo Dibyo , Syakir Muhammad
Published: December 2022

Tanaman porang dapat dikembangkan secara vegetatif menggunakan bulbil. Ukuran bulbil sangat beragam dan diduga akan berpengaruh terhadap pertumbuhan dan hasil umbi. Selain itu, komposisi media tanam yang terdiri dari tanah dan pupuk kandang (pukan) ayam dengan proporsi yang berbeda diduga akan berpengaruh juga terhadap pertumbuhan tanaman dan hasil umbi. Penelitian ini bertujuan untuk menganalisis pengaruh ukuran bulbil dan komposisi media tanam yang terdiri dari campuran tanah dengan pukan ayam terhadap pertumbuhan dan hasil tanaman porang. Percobaan dilakukan di Kebun Percobaan  Pakuwon, Sukabumi, mulai September 2021 sampai Februari 2022. Rancangan percobaan yang digunakan adalah rancangan petak terpisah dengan 3 ulangan. Petak utama adalah ukuran bulbil yang didasarkan pada bobot bulbil: (1) ukuran kecil (5,03-8,48 g/bulbil), (2) sedang (9,40-11,50 g/bulbil), dan (3) besar (12,35-15,62 g/bulbil). Anak petak adalah komposisi media tanam: (1) tanah (100%), (2) tanah:pukan ayam dengan proporsi15:1 (v/v), (3) tanah:pukan ayam dengan proporsi 10:1 (v/v), dan (4) tanah:pukan ayam dengan pproporsi 5:1 (v/v). Peubah yang diamati meliputi: tinggi tanaman, diameter batang, lebar tajuk, serta tebal, diameter, dan bobot segar umbi. Hasil penelitian menunjukkan bahwa bobot bulbil tidak berpengaruh terhadap pertumbuhan dan hasil porang, kecuali terhadap tinggi tanaman pada pertumbuhan vegetatif awal. Aplikasi pukan ayam sebagai media campuran  tanah memberikan pengaruh yang positif. Komposisi media tanam yang terdiri dari tanah:pukan ayam dengan proporsi 5:1 menghasilkan pertumbuhan dan hasil porang yang paling tinggi. Media tanam dengan proporsi tersebut sesuai diaplikasikan pada semua ukuran benih (bulbil) porang.
Features of the Behavior of a Plane Axisymmetric Mag-netic Fluid Drop in a Nonmagnetic Solvent and a Uni-form Magnetic Field
Authors: Bashtovoi V. G. , Reks A. G. , Zahadskaya A. A.
Published: December 2022

The work is devoted to an experimental study of the process of dissolution of a magnetic fluid in a nonmagnetic solvent under the action of a uniform magnetic field. It is experimentally established that in a volume of magnetic fluid surrounded by a miscible solvent fluid, under the action of a uniform magnetic field, a mechanical movement arises, triggering deformation of this volume. Initially, the axisymmetric volume of the fluid takes an ellipsoidal shape, lengthening along the magnetic field direction. The main reason for this movement is the pressure differences in the magnetic fluid, caused by jumps and nonuniformities of the magnetic field at the interface between magnetic and nonmagnetic media. Simultaneously with the mechanical motion, the diffusion dissolution of the magnetic fluid occurs, which is also accompanied by the motion of the diffusion front at the interface between the fluids. The concentration gradients of magnetic particles that arise in this case cause gradients of the magnetization of the fluid and, as a consequence, gradients of the magnetic field intensity. Together, this triggers the appearance of a bulk magnetic force in the magnetic fluid, and the pressure gradients associated with it. The main regularities of this process have been established, viz. the dependence of change of the geometric characteristics of the volume and its deformation rate on time. It is shown that at the initial stage of the process, the rates of mechanical movement of the boundaries of the magnetic fluid volume are much higher than the rates of movement of the diffusion front. Thus, the initial rate of mechanical elongation of the droplet under the experimental conditions is 0.25 mm/min, and the diffusion front rate is 0.08 mm/min. Over time, these processes slow down and stop when the volume of the magnetic fluid is completely dissolved. Herewith, the mechanical elongation of the drop is the first to stop and, in the case under consideration, takes about ten minutes.
Methods and Technical Means for Ensuring Uniformity of Nanoparticle Size Measurements
Authors: Bagdun A. A. , Solomakho V. L.
Published: December 2022

The paper proposes a set of technical tools for solving the problem of ensuring the uniformity of measurements of micro- and nanoparticles. To do this, it is necessary to ensure the traceabilityof particle size measurements to a unit of length – a meter, as well as equivalent diameters used in measurements in various dispersed media (aerosols and suspensions). To ensure traceability of particle diameter measurements to the meter, it is proposed to use a nanomeasuring machine with an atomic force microscope as a probing system. The paper presents a diagram of the measuring system, describes the principle of operation of the machine and the method for measuring particle sizes. The main alleged sources of errors in particle measurement by this method are also identified. To ensure the traceability of measurements of the hydrodynamic diameter of nanoparticles, which characterizes particles in a liquid (suspension), it is proposed to use a nanoparticle size analyzer that implements the method of dynamic light scattering. The scheme of the analyzer with a description of the principle of measuring the size of nanoparticles by the method of dynamic light scattering is presented in the paper. The scheme of the column of the analyzer of the differential electrical mobility of particles is presented to ensure the traceability of measurements of their diameter, which is equivalent in electrical mobility. Diameter is usually used to characterize particles in the aerosol state. A diagram of an analyzer for the differential electric mobility of particles is given with a description of the operating principle, a formula for calculating the particle diameter is derived.
Importación del acai de Campo Grande – Brasil para la diversificación de Frozcape Perú, 2022
Authors:   , Alarcon Moyeda Milagros Sulay , Cancho Camasca Gladys Yovana , Oscategui Ugarte Milagros Adriana , Solis Carhuavilca Ashly Paola
Published: December 2022

El presente plan de negocio consiste en la importación de acai brasilero y la diversificación de la cartera de productos de la “HELADERÍA FROZCAPÉ”, la misma que se dedica a la fabricación y venta directa de los helados ecológicos y artesanales; este se encuentra ubicado en Santa Eulalia y Callahuanca - Huarochirí que son centros turísticos. En la actualidad, la competencia brinda la misma variedad de productos que Frozcapé por lo cual nos sentimos en la obligación de diversificar para poder captar mayor mercado, debido a esta misma necesidad se insertará a nuestra cartera el acai brasilero por sus propiedades nutritivas y su creciente aceptación en el mercado internacional para la elaboración de helados en la empresa Frozcapé en el año 2022. Al realizar una encuesta a nuestros consumidores recurrentes en el cual el 74% de las 50 personas encuestadas nos hicieron saber que están entusiasmados por probar este nuevo sabor y muy aparte de eso, que están emocionados por nuestra diversificación en productos.
Comparación de la microdureza superficial de resinas para construcción de muñones. Estudio in vitro
Authors:   , Revollar Cardenas Jesus Alfredo
Published: December 2022

Objetivo: Comparar a las 48 horas la microdureza superficial de las resinas para reconstrucción de muñones Z350 XT 3M, Luxacore DMG America y Absolute Dentin PARKELL. Materiales y Método: El grupo de estudio estuvo conformado por 33 discos de resina, distribuidos en tres sub grupos (n=11), uno control y dos experimentales, siendo el primer grupo una resina de foto activación (G1= Z 350 3M ESPE) y los dos últimos grupos resinas de activación dual (G2= Luxa Core DMG, G3= Absolute Dentin PARKELL), los cuales fueron medidos mediante un microdurometro Vickers (LG). Se alcanza la identacion mediante una carga de 200 gramos/fuerza por un periodo de 10 segundos. El análisis estadístico se realizó con ayuda del programa SPSS Statistics V24 y se compararon las variables mediante la prueba de Anova de un factor para muestras independientes y la prueba de comparaciónes múltiples de tukey. Resultados: Luego del ensayo de microdureza Vickers (VHN) los resultados promedio fueron: para G1 se obtuvo 75.66 ± 4.4 VHN, G2 arrojó un valor promedio de 55.24 ± 1.7 VHN. Mientras que el promedio de microdureza para G3 fue de 54.34 ± 3.82 VHN. Conclusiones: Las resina compuesta foto activada como material de reconstrucción de muñones sometido a la prueba de microdureza superficial, presento valores de microdureza superficial mayores que las resinas duales evaluadas. Sin embargo, los valores de las otras 2 resinas presentaron valores dentro del promedio permitido.
Percepción de la aplicación del consentimiento informado en pacientes de endodoncia de la Clínica Estomatológica de la Universidad Científica del Sur 2019
Authors:   , Tejeda Ventura Alberto Sigi
Published: December 2022

El presente trabajo de investigación tuvo como objetivo determinar la percepción de la aplicación del consentimiento informado en pacientes de endodoncia de la Clínica Estomatológica de la Universidad Científica del Sur. El tipo de investigación que se utilizó fue descriptivo transversal. Se utilizó como instrumento de evaluación el cuestionario titulado “percepción del proceso de consentimiento informado en paciente de la clínica estomatológica de la universidad Peruana Cayetano Heredia” previamente validad. Se determinó una muestra de 94 pacientes, de tipo probabilístico, de los cuales 50 fueron mujeres y 44 hombres, con edad promedia de 44 años de edad. Se encontró que en cuanto a la percepción de las dimensiones autonomía, información y entendimiento alcanzaron un puntaje de favorable y la de valores obtuvo un puntaje de muy favorable. No se encontró asociación con las covariables: sexo, nivel de instrucción ni ocupación. En conclusión, existe un nivel favorable en la percepción de la aplicación del consentimiento informado en pacientes de endodoncia.
E-commerce y su relación con el comportamiento del consumidor de la empresa La Casa Artesanal, Ate - 2021
Authors:   , Centeno Diaz Cesar Luiggi
Published: December 2022

El objetivo del estudio fue determinar la relación entre E-commerce y el comportamiento del consumidor de los consumidores de la Casa Artesanal durante el periodo de pandemia por el Covid – 19. Esta investigación tuvo un enfoque cuantitativo, de diseño no experimental - tipo transversal, correlacional - descriptivo. La muestra estuvo conformada por 152 consumidores de la empresa la Casa Artesanal. Para la V1 se tiene un alfa de Cronbach de 0.82 y para la V2 uno de 0.79. Los resultados evidenciaron que existe una correlación moderada baja de 0.442 entre el E-commerce y el comportamiento del consumidor de la Casa Artesanal.