bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative analysis of the antihepatotoxic effects of Ginkgo biloba leaf extract and Legalon using histological and biochemical techniques
Authors: El-Shabasy Eman A , AA Amer Maher , Keshk Fatma A , Shabana Sameh M
Published: February 2023

Drugs, alcohol, and poor nutrition all contribute to the overproduction of free radicals, which linked to numerous diseases and resulted in a high number of cases of liver injury. Antioxidants have shown to play a significant role in reducing the harm caused by these compounds in recent studies. Treatment of liver disease with plants from the natural world has received considerable attention for quite some time. This study compared Ginkgo biloba leaf extract (GbE) with a commonly used drug in Egypt called Legalon for treating liver disorders, in order to assess GbE's hepato-protective effect against hepatotoxicity induced experimentally by CCl4. Before the first dose of CCl4, animals given GbE (100 ml/kg) and Legalon drug (100 ml/kg) orally, once a day, for a week. After that, CCl4 given orally at a dose of (2.5 ml/kg) in olive oil daily for 8 weeks to induce liver fibrosis, and the administration of GbE and Legalon maintained at the same dose and duration. The protective effect of GbE was determined by observing the result of the experiment, which included a shift in biochemical indictors and the outcomes of histopathological studies. In comparison to the control group, CCl4 significantly (P<0.5) increased the levels of ALT, AST, ALP, MDA, and lipid profile. In contrast, markers of oxidative stress, including TP, ALB, HDL, TAC, GSH, GPx, CAT, and SOD, were significantly lower in the study's experimental group than in the control group. Nevertheless, GbE treatment led to differences across the board when compared to the CCl4-intoxicated and Legalon groups. With the help of the histopathological investigations, all of these findings verified. Conclusion: Liver damage caused experimentally by CCl4 mitigated when the animals pretreated with GbE. Both biochemical and histopathological studies found that GbE acts as a powerful antioxidant, suppressing oxidative stress to reduce hepatotoxicity and slow the development of liver fibrosis.
Randomized clinical trial to test the safety and tolerability of SBD111, an optimized synbiotic medical food combination designed for the dietary management of the metabolic processes underlying osteopenia and osteoporosis
Authors: Sahni Shivani , Schott Eric M , Carroll Danette , Soto-Giron Maria J , Corbett Susan , V Toledo Gerardo , P Kiel Douglas
Published: February 2023

To determine the effect of a twice daily administration of SBD111 on safety and tolerability in healthy adults in a randomized, placebo-controlled trial over 28-days. Participants were randomized to either SBD111 (n=15) or placebo (n=17). The outcomes were the number, frequency, and severity of Gastrointestinal (GI) symptoms and the number and severity of adverse events (AEs) over 28-days. Stool samples were collected and analyzed at baseline, after 28- and 56-days. Groups were compared (P< 0.05) using an intention-to-treat approach. The two groups were similar at baseline. After 28-days, the presence of GI symptoms tended to be higher with SBD111 use vs placebo (P=0.08) but the total number, frequency/severity of GI symptoms did not significantly differ. The number of AEs possibly related to the study were higher with SBD111 use vs placebo (P=0.05), there were no significant differences in the mean number/severity of AEs. The majority of reported AEs were mild, some were moderate, but none were severe. There were no significant differences in alpha diversity indices between the two groups at baseline or follow-up. SBD111 strains were identified in stool, enriched metabolic pathways for menaquinone (vitamin K2) production at 28-days, and were not detected at 56-days. The relatively low frequency and mild severity of GI symptoms and AEs suggests that SBD111 at the level tested is safe for human consumption.
Contamination with Enterococcus spp., strains of lettuces of different species acquired in Cumaná
Authors: Patiño L Abadía , MF Bastardo
Published: February 2023

Lettuce is one of the most common crops in the world, with high index of vitamins, minerals and fiber. Raw food consumption is closely related to foodborne illness, of which Escherichia coli O157:H7, seems to be the prime perpetrator leading to undesirable consequences. However, E. coli is not the only microorganism that can be transmitted, as reports validating the involvement of Aeromonas, Yersinia, Listeria, Staphylococcus, Campylobacter, and Salmonella have surfaced. The objective of this work was to detect the contamination of lettuces of different species acquired in several places of Cumaná, with Enterococcus strains. Of 52 lettuces acquired in food retail centers, 38% were contaminated with Enterococcus spp., strains. The best-selling lettuce was Lactuca sativa L. (25/52), but the most contaminated was Lactuca sativa var. capitata (89%). The highest average for Enterococcus was obtained in lettuces from Municipal Market. The dominant species of Enterococcus were E. faecalis (40%), and E. casseliflavus (30%); and to a lesser extent E. faecium (15%), E. gallinarum (10%), and E. avium (5%). The susceptibility profile showed that there are strains resistant to glycopeptides, fluoroquinolones, ansamycins, macrolides, phenols and tetracyclines. The clonal dissemination of two strains of E. faecalis and one strain of E. faecium by antibiotyping was demonstrated in lettuces from the municipal market. These results demonstrate that the food chain is a route of dissemination of multidrug resistant Enterococcus to the human intestinal microbiota, turning the gastrointestinal tract into a reservoir of intractable bacteria with the available antibiotics.
Time dependent growth pattern study of Lactobacillus spp. and Bifidobacterium spp. in the presence of Tartrazine; an azo dye
Authors: Tirumalai Prem Saran , Pathak Rimjhim , Kashyap Seema
Published: February 2023

Tartrazine is an azo dye that is widely used in the food and pharmaceutical industry. It is also known to have a potential impact on human health. Reports indicate possible carcinogenic and mutagenic effects of the dye. Joint expert WHO/ FAO committee on food additives, Codex Alimentarius Commission (CAC) have defined permissible limits for the use of tartrazine in fermented food products, including probiotic drinks, yet the dye finds wide usage as an additive. This study demonstrates the probable effect of tartrazine, at different concentrations on Lactic acid bacteria commonly used as starter cultures and probiotics. This study indicates the effect of tartrazine in particular on Lactobacillus casei, Lactobacillus plantarum, Bifidobacterium bifidum.
Facial artery, an essential anatomy in different specialties: a review
Authors: Angulo K Constanza , Amin M Marta , Novoa C Ignacio , Araya B Diego , Mercado M Víctor
Published: February 2023

The facial artery presents various patterns of anatomical distribution. Its collaterals and terminal branches require permanent review by professionals who perform invasive and minimally invasive procedures in the face territory. The varied anastomoses of the territory of the external carotid and the ophthalmic artery -coming from the Internal Carotid-make it necessary to act with caution against possible complications when minimally invasive procedures are performed such as the injection of "filler" (mainly hyaluronic acid) for aesthetic purposes. That is why the clinical analysis prior to any procedure at the face level makes it necessary to integrate an analysis of the detailed knowledge of the tremendous anatomical variability of the facial artery, which will allow better results, less morbidity, and minimize the risks of vascular complications.
Parapharyngeal solitary fibrous tumor (SFT): case report and literature review
Authors: Pacheco Z Rodrigo , Ortega Flores Gonzalo
Published: February 2023

The parapharyngeal space is a region where a wide spectrum of lesions can arise. They are rare and involve only 0.5% to 1.5% of head and neck neoplasms that usually present as asymptomatic masses. Literature describes multiple histopathologic variants that can arise from this area, among them, there are solitary fibrous tumors, an spectrum of fibroblastic mesenchymal neoplasms of uncertain histogenesis that often involve the thoracic pleura, hence it’s parapharyngeal location is exceptional. We present a case of a solitary fibrous tumor of the parapharyngeal space with its diagnostic process, surgical resolution and follow-up.
Mental health issues of fire personnel: an exploratory study
Authors: N Navya , Sindhu Brahmdeep , Banerjee Padmakali , Sindhu Nehal , Ola Manpreet
Published: February 2023

The primary goal of the current study was to add to the literature regarding mental health implications of fire service membership. In the present study, 100 fire personnel were selected working in Haryana state of India. The DSM V cross cutting Questionnaire was used to assess mental health issues of the fire personnel and the results suggested that firefighters self-reported greater posttraumatic symptomatology on anger and substance issue domain of the test. In addition, the firefighters reported more distress on several subscales of the DSM V cross cutting Questionnaire
Evaluation of the use of psychotropic medication as needed for hospitalized child and adolescent patients and for those children in a residential treatment program
Authors: Calhoun Joshua W , Khoo Yit Mui , Watts Dan
Published: February 2023

Objective: The goal of this study was to evaluate the use of psychotropic medication as needed (Symptomatic treatment) (pro re nata or prn) in children and adolescents in a psychiatric hospital and those children in the residential treatment program. Methods: The pro re nata medication use of all 152 unduplicated patients admitted to Hawthorn Children’s Psychiatric Hospital in St. Louis, Missouri (USA) beginning in April 2015 through March 2016 were reviewed for this study. The medication orders of all patients are placed electronically. Reports on prn medication use at the facility were obtained from the electronic medication administration (e-MAR) utilizing the MetaCare software. Results: In this study, gender, race, and health insurance coverage had no statistically significant association with prn medication usage. However, the child’s age did have a statistically significant association (p<0.01) with prn medication usage. Inpatients younger in age were more likely to have received prn medications during their hospitalization. Conclusion: Due to little empirical evidence for prn’s in younger children and these results show an increased use in younger patients, our data suggests that prn’s be limited when treating these patients. This data also endorses behavioral treatments to be utilized before a prn is administered
Management of psychomotor agitation: audit of clinical practice
Authors: Abdul Karim Mustafa , Torki Yassin El , Felfel Inas , Hoseny Sali El , Hashem Hazem
Published: February 2023

Background: Psychomotor agitation (PMA) is encountered in different psychiatric settings, with prevalence ranging between 4.3 and 10%. According to The Maudsley Prescribing Guidelines in Psychiatry, stepwise management of PMA starts with behavioral intervention, followed by parenteral rapid tranquillization and physical restraint as last resorts. Our primary aim is to determine whether we follow the stepwise management of PMA. Our secondary aims are to assess the type and frequency of different psychotropics used to manage PMA, and the rate antipsychotic combination. Methods: We enlisted all patients who were prescribed psychotropics, ordered as “PRN for Agitation”, both in the emergency department and psychiatry inpatient units, between January the 7th and March the 4th of 2018, and retrospectively analyzed their electronic medical records for documentation of PMA and behavioral interventions implemented. In addition, we assessed the type and frequency of different psychotropics used for chemical restraint. Results: 76 patients met our criteria. PMA was documented in 32.4 % of the cases, with five presenting with severe agitation. 21 instances of PMA occurred while patients were in the emergency department (ED), pending admission to psychiatry inpatient units. Behavioral intervention was only documented in 9.5% of the cases in the ED, compared to 48% in the inpatient units. The most frequently prescribed regimen for managing PMA was the combination of Intramuscular (IM) Haloperidol and Diphenhydramine, at a rate of 66%, followed by IM Haloperidol and Lorazepam (19.12%) and IM Haloperidol and Promethazine (8.82%). Compliance with the route of administration was only observed in 26% of cases, and the rate of neuroleptic co-administration was 68%. Conclusion: In managing PMA, there is insufficient documentation of behavioral intervention. Compliance with psychotropic route of administration for chemical restraint was poor, as parenteral tranquillizers were the preferred agents, without initially resorting to oral psychotropics. In addition, most of our patients were prescribed more than one antipsychotic. Through a multidisciplinary approach, our goal is to improve compliance with the proposed guidelines in managing PMA, and minimize the rate of neuroleptic co-administration
Behavior of adipocytes in the mammary niche during pregnancy and lactation
Authors: de Alvarenga Erika Costa , Vasconcellos Rebecca , C. Picoli Caroline , Cost Raquel Alves , Medrado Nathanael Vieira , Mileib Raisa , Castro Rosiane , M Sales Vicencia
Published: February 2023

Primarily, the adipose tissue is known for its function storing excess energy as fat. This tissue is also an endocrine organ and communicates with several tissues, such as muscle, liver and brain. In addition, the adipose tissue is an accessible source of adult stem cells. Autologous adipose tissue transplant used for plastic surgery purposes take advantage of this feature. These pluripotent cells are also targets for gene therapy and autologous transplant in regenerative medicine. A recent study using state-of-art technology explores the plasticity within mature adipocyte into stroma of the mammary gland. Strikingly, adipocyte-derived preadipocytes de-differentiate and re-differentiate repeatedly, during pregnancy to accommodate the new imposed body metabolic demand. The emerging knowledge from this study is essential to understand the cellular processes occurring into the mammary gland during pregnancy, lactation, and involution. This idea opens new perspectives to study the involvement of the adipose tissue in systemic regulatory processes during these transitional states and has implication on conditions as cancer and inflammation-related diseases.
Therapeutic role of mesenchymal stem cells seeded dermal matrix versus acellular dermal matrix in healing of skin defect
Authors: Omar Sahar MM , Mohamed Ghada F , Moussa Manal H , Abo Zeid Asmaa A , Baher Walaa , Mohammed Assem , Sobhy Mohamed , Sabry Ahmed , Adel Omar
Published: February 2023

Background & objectives: One of the major challenges facing the surgeons is replacing a full-thickness skin loss successfully. This study aimed at testing the efficacy of decellularized dermal matrix seeded with bone marrow-mesenchymal stem cells (BM-MSCs) as a scaffold for the repair of skin defects in rats comparison to using acellular dermal matrix (ADM) alone. Methods: A 2×2 cm2 size full thickness skin defect was created on the dorsum of thirty male Wister rats (200- 250g) under xylazine (5 mg/kg) and ketamine (50 mg/kg) anesthesia. The animals were then randomly divided into three equal groups: group I; The defect was left for spontaneous recovery, group II; The defect was repaired with ADM alone, and group III;Tthe defect was repaired with ADM seeded with labeled BM-MSCs. The healing rate of the defect in all groups was assessed by measuring wound area and healing percentage twice weekly. The specimens from the wound site were obtained from all groups on day 14 and day 28 post-operative for histological analysis. Results: Treatment of wound defect with BM-MSCs seeded dermal matrix resulted incomplete wound recovery on gross examination. Moreover, histological analysis showed proper reepithelization, proper collagen rearrangement together with minimal inflammatory cells. Well developed hair follicles and sebaceous glands were noted as well. Statistically, 28 days post-operatively, significant increase in healing rate, healing area percentage and collagen area percentage was detected together with significant decrease in vascular density compared to group I&II. Conclusion: Stem cells seeded ADM facilitated early and better healing of skin defect in rats than the non- seeded ADM and spontaneous healing.
Phase controller outperforms impedance controller for a hip exoskeleton
Authors: G Sugar Thomas , Redkar Sangram , W Hollander Kevin
Published: February 2023

Developing controllers for exoskeletons has many challenging requirements: one of which is creating a torque command based on measured human data that that is in phase with the user (in-synchrony with the human gait). We show that the hip torque for walking gait can be modeled using a phase angle based on hip angular position and velocity. This model is superior to a standard impedance model based on inertia, damping, and stiffness parameters because the phase model uses less parameters and they change linearly with varying speed and weight. The controller has been tested on ten subjects (weighing from 68 to 118kg) wearing the hip exoskeleton walking at speeds from 0.7 to 1.8m/s in outdoor environments.
The relation between posture and fighting style: case of kung fu wushu (sanda)
Authors: Ayoub Haceini
Published: February 2023

The aim of this study is to analyze the relationship between initial posture (pre-contact posture) and combat style (boxing, foot and fight); thus, to establish a specific modeling. The descriptive analytical method of the video recordings of the combats organized with our sample (n=6) (2 of each combat style) was used to obtain the initial kinogram via the Dart Fish software. Inter-style postural similarities and extra-style postural differences were found, which helped us to put in place specific postural indices. Knowing the opponent's fighting style may betray some of his combat strategy, but can we hide these postural clues? Or more, can we give false clues (a lure) to deceive the opponent, which will make combat a rather mental challenge.
Models and data analysis of the outbreak risk of COVID-19
Authors: Zhao Bin , Cao Jinming , Jiang Xia
Published: February 2023

With the spread of the new corona virus around the world, governments of various countries have begun to use the mathematical modeling method to construct some virus transmission models assessing the risks of spatial spread of the new corona virus COVID-19, while carrying out epidemic prevention work, and then calculate the inflection point for better prevention and control of epidemic transmission. This work analyzes the spread of the new corona virus in China, Italy, Germany, Spain, and France, and explores the quantitative relationship between the growth rate of the number of new corona virus infections and time. In investigating the dynamics of a disease such as COVID-19, its mathematical representation can be constructed at many levels of details, guided by the questions the model tries to help answer. Mathematical sophistication may have to yield to a more pragmatic approach closer to the ability to make predictions that inform public health policies. Background: In December 2019, the first Chinese patients with pneumonia of unknown cause is China admitted to hospital in Wuhan, Hubei Jinyintan, since then, COVID-19 in the rapid expansion of China Wuhan, Hubei, in a few months time, COVID-19 is Soon it spread to a total of 34 provincial-level administrative regions in China and neighboring countries, and Hubei Province immediately became the hardest hit by the new corona virus. In an emergency situation, we strive to establish an accurate infectious disease retardation growth model to predict the development and propagation of COVID-19, and on this basis, make some short-term effective predictions. The construction of this model has Relevant departments are helpful for the prevention and monitoring of the new corona virus, and also strive for more time for the clinical trials of Chinese researchers and the research on vaccines against the virus to eliminate the new corona virus as soon as possible. Methods: According to the original data change law, Establish a Logistic growth model, we collect and compare and integrate the spread of COVID-19 in China, Italy, France, Spain and Germany, record the virus transmission trend among people in each country and the protest measures of relevant government departments. Findings: Based on the analysis results of the Logistic model model, the Logistic model has a good fitting effect on the actual cumulative number of confirmed cases, which can bring a better effect to the prediction of the epidemic situation and the prevention and control of the epidemic situation. Interpretation: In the early stage of the epidemic, due to inadequate anti-epidemic measures in various countries, the epidemic situation in various countries spread rapidly. However, with the gradual understanding of COVI D -19, the epidemic situation began to be gradually controlled, thereby retarding growth.
Model of water-salt balance in the new irrigation territory of the karshin steppe
Authors: Umid Abdusamadovich Sadiev , Azizbek Ilkhomzhonovich Ernazarov , Ilkhomjon Ernazarovich Makhmudov
Published: February 2023

The article presents a methodology for the development of a model of salt transfer in the conditions of a stationary water-salt regime of soil-grounds, caused by furrow irrigation of cotton.
Feather degradation efficiency and hide dehairing ability of a new keratinolytic bacillus halotolerans strain, isolated from a tannery wastewater
Authors: Ouertani Rania , Chouchane Habib , Mahjoubi Mouna , Khdhira Hechmi , Saleheddine Masmoudi Ahmed , Cherif Ameur , Neifar Mohamed
Published: February 2023

Here, we report a new keratinolytic-producing bacterium identified as Bacillus halotolerans 4BC based on 16S rRNA gene sequencing. 4BC strain isolated from a tannery wastewater, showed proteolytic activity when grown on keratin azure, bovine hair and feather meal agar plates. B. halotolerans 4BC degraded almost 88% of chicken feathers after 10 days of cultivation in feather powder broth at pH 8 and 37°C. It was also efficiently able to degrade bovine hair keratin, despite the complexity of this substrate in comparison to feather keratin. The effects of different liquid to substrate ratios, inoculum sizes and incubation times on keratinase production were studied using response surface methodology to find the optimum conditions required for maximum B. halotolerans keratinase yield. The maximum keratinase yield (1059±53 mU/ml) was found under the following conditions: incubation period of 10 days, liquid/solid ratio of 5 and inoculum size of 2.3 % v/v). The crude enzyme exhibited a remarkable activity and stability under high temperature and alkaline conditions (pH 10 at 80°C). Additionally, the touch-visual and histological results demonstrated that the enzyme treated dehaired hides exhibit similar or improved characteristics without damaging the collagen layer, which makes the crude keratinase a potential effective and eco-friendly candidate for application in leather industry to avoid pollution problems associated with the use of chemicals.
Biomechanical aspects of Tai Chi Chuan countermeasure against health threats during spaceflight
Authors: Chu T Julian , H Szu Harold
Published: February 2023

In support of NASA’s plan to establish human settlements on the Moon and Mars in the near future and the emergence of cutting-edge artificial intelligence as a tool for better health care, we look for ways to help astronauts stay physically and mentally healthy during a long and stressful trip. After reviewing existing aerobic and strength exercise methods available to astronauts, we propose that traditional Tai Chi Chuan (TCC) or Taijiquan can serve as a non-invasive intervention to help astronauts maintain physical and physiological integrity and cope with the impact of microgravity during and after spaceflights. Biomechanical aspects of TCC in terms of neuromuscular and musculoskeletal conditions are presented based on a review of evidence from the scientific literature that defines physiological responses associated specifically with the practice of TCC as relevant to space mission-related effects of microgravity on human physiology. This article provides a comprehensive review and description of the TCC biomechanics and their health influences in microgravity. The mysterious Chi (or Qi) of TCC is scientifically defined as kinesthetic sensations of position, movement, and force of muscles, tendons, and joints throughout body segments in kinetic chain motions. These sensations can be used to judge the correctness of TCC trainings as a countermeasure against microgravity to improve proprioception, kinesthesia, and mind-body coordination for astronauts. This study has far-reaching implications for the integration of TCC practices in complement with the effectiveness of existing countermeasure approaches, and provides direction for future research that might bridge the knowledge gap in improving exercise countermeasures for human spaceflight.
How Homo-sapiens began our journeys on the Earth?
Authors: H. Szu Harold
Published: February 2023

We provide a “reader digest” version about the life forms evolved on the Earth and wish to emigrant to the other planet. E.g. Moon, Mars. First of all, the enormous gravitational force attracted two huge massive black holes (because photons could not be escaped) into a big bang collision circa 13.8 billion years (estimated by the background radiation 3oK). It has produced the spinal shape Milky Way (due to the conservation of angular momentum). The Milky Way is filled with stars and planets, according to 2020 Nobel Prizes in Physics by Roger Penrose (Oxford) and Andrea Ghez(UCLA), as well as Reinhard Genzel (Max-Planck) based on the NSF NASA supported Laser Interference Gravitationwave Observation (LIGO) experiments (operated by MIT & Caltech). We wish to answer how we began our life journeys on the Earth. Burning hydrogen’s became the water on almost all the planets. The Sun fused about 13 helium atoms to the heavy element irons and ejected out and captured by the bigger and closer Earth than the Mars. Then the Earth core fission some iron isotopes generated spinning current produced kilo-Tesla magnetic field which has warded off the constant bombardment of solar flares burning off water from the Earth. The water interacted with other chemical element Nitrogen and Carbon to build about 20 amino acids to proteins for regenerative beings. The reproduction is made of billions twisted pairs and spooling winding together into DNA genes in each cell with dozen co-evolved partners Mitochondria with its own DNA into reproductive life.
Sexual libido of the elderly woman: myth of asexual old age
Authors: Sarmento Diniz Edienne Rosângela
Published: February 2023

The aim of this article is to analyze the scientific evidence that addresses the factors that interfere in the sexuality of the elderly. The search was carried out in pairs, online, including original articles that were in the Portuguese, English or Spanish language and answered the study objective. Had by Database: Medline, Lilacs, CIDSAÚDE and BDENF. The selected articles were evaluated for methodological quality by means of two instruments: CASP and the Hierarchical Classification of Evidence. After analysis, 7 articles were included in the review, which discuss the culture of asexuality of the elderly.
Subcapsular hepatic hematoma as a complication associated with ERCP: presentation of a case in a geriatric patient
Authors: Gutiérrez Héctor Miguel Angulo
Published: February 2023

Introduction: A 68-year-old female patient who began her condition with the presence of transfictive pain in the epigastrium, presenting pancreatitis diagnosed by tomographic, clinical and biochemical parameters, and later performing endoscopic retrograde cholangiopancreatography, subsequently with data compatible with hepatic sub capsular hematoma by tomography, in addition to presenting bilateral pleural effusion, the treatment of the hematoma was purely conservative. Radiological follow-up was performed during the following two weeks, evidencing progressive hemolysis of the hematoma. Discussion: Hepatic sub capsular hematoma is a rare complication of endoscopic retrograde cholangiopancreatography. The presentation of this type of complications is infrequent and little reported in literature, the exact mechanism by which it can occur is not yet known, however in several reports it is thought that the metallic guide produces accidental injury of a hepatic blood vessel and, consequently, produces a bleeding that accumulates under the hepatic capsule, producing pain in the right hypochondrium due to the distension of the same. In addition to the pain, the drop-in hemoglobin is a suspicion of this condition. In this case, the patient presented with hypovolemic shock, presenting prerenal kidney injury requiring renal replacement management, was managed with crystalloid solutions, blood transfusion, conservative management and serial tomographic controls. In addition to having a bilateral pleural effusion that did not merit interventionist management. The treatment of the hematoma reported by the majority of authors has been conservative with restitution of blood loss and volume, surgical treatment is reserved for cases with patient deterioration, hemodynamic instability and data of peritoneal irritation that can lead to a broken hepatic hematoma. Conclusion: The pathology of hepatic sub capsular hematoma is a rare complication of endoscopic retrograde cholangiopancreatography that its management will require supportive management and only merits surgical management if it ruptures.
Liver fibrosis has a different effect on the "lifespan" of lymphocytes and neutrophils in the in vitro system isolated from the bone marrow of young and old rats
Authors: AI Bozhkov
Published: February 2023

Background: The content of lymphocytes and neutrophils in the bone marrow of young (3 months) and old (20 months) rats was investigated. The ability of lymphocytes to proliferate after transferring the bone marrow cells of young and old animals to the primary culture and the "lifespan" of neutrophils in culture, as well as the effect of liver fibrosis in young and old animals on the studied cell characteristics was determined. Methods: Experiments were performed on male Wistar rats two age groups: young (3 month old) and old (20 month old) ones. Animals were divided into groups: an intact control group, a group with Cu–induced liver fibrosis and a group with CCl4–induced liver fibrosis. Cu–induced fibrosis was induced by repeated administration of copper sulphate, CCl4–induced fibrosis was induced by multiple intraperitoneally administration per chloromethane mixed with olive oil. Bone marrow cells were isolated from the 2 femoral bones of the rat, 8 animals were used in each variant. Cells cultured in medium 199 with HEPES and 20% inactivated fetal calf serum and antibiotics. Results: The content of lymphocytes in the bone marrow of old animals was 167% more than in young ones. Induction of liver fibrosis with copper sulfate increased the lymphocyte count in the bone marrow in young animals by 167% and in old animals only by 26%. While the induction of fibrosis with carbon tetrachloride increased the content of lymphocytes in young animals by 71%, and in old animals, on the contrary, decreased their number by 33%. The "lifespan" of neutrophils isolated from old animals was higher in the primary culture than from neutrophils obtained from young animals. Liver fibrosis reduced the "lifespan" of neutrophils in culture. Possible mechanisms of this phenomenon are discussed.
The lack of family support to the institutionalized elderly: an integrative literature review
Authors: Boas Dias Bruno Vilas
Published: February 2023

Objective: To identify through literature, the consequences of the lack of family support to the institutionalized elderly. Method: Integrative literature review through databases: SCIELO, LILACS, BDENF, MEDLINE, Scielo. Five descriptors were defined: elderly, family relationships, frail elderly, health of the elderly and health of the institutionalized elderly, associated with the Boolean operator. Results: 5072 articles were found and selected according to the inclusion criteria, nine of them. Conclusion: It can be observed that the lack of family support for the elderly has unpleasant consequences in the lives of the elderly, making them susceptible to the appearance of negative feelings, frailty and depression.
Aging of balance and risk of falls in elderly
Authors: Cisternas Yeny Concha
Published: February 2023

Aging is a universal, irreversible and individual processthat causes morphophysiologicalchanges in the musculoskeletal systems, central nervous system and sensory systems (visual, vestibular and proprioception), causinggreaterrisk of falls. The falls have a high prevalence and have become an important public health problem due to the high economic and functional costs they represent in the elderly. To avoid these events it isimportanttoknowtheanatomophysiologicalchangesassociatedwithaging and plan healthstrategieswherebone, muscle, somatosensory (proprioceptive) and cognitivestimulation is incorporated with the aim of avoiding functional impairment and disability.
Impression metadiaphyseal fractures of the proximal end of the leg bones and our experience
Authors: Shahidul Islam , IYu Khodzhanov , DR Elov , Sh, Ruzikulov U , Shayan R Bari AM
Published: February 2023

Introduction: Impression fractures of the proximal end of the tibia occupy the main place in the appearance of defor-mation of the articular surfaces. The goal is to improve the results of treatment of impression fractures of the proximal end of the shin bones, based on clarifying the volume of impression defects and filling the residual cavities. Materials and methods: The study analyzed the data of 32 patients with impression fractures of the proximal end of the tibia. The volume of the formed cavities was determined according to the program for the MSCT study (per cubic centimeter measurements). V = length *thickness *width *0.52 = cubic cm, the method by which radiation diagnostics doctors work and display the volume of the cavity in cubic centimeters. V cavity volume \u003d cavity length *cavity thickness *cavity width *0.52 \u003d cc / cm (0.52 is the accepted average value, standard). Results: The results were also studied according to the accepted methodology compiled by the crite-ria for evaluating the results, and they turned out to be the following in terms of the totality of the treatment performed: in 25 patients it was from 62 to 76 points, i.e. good, in 7 patients they were satis-factory, i.e. averaged 58 points, there were no unsatisfactory result. Discussion: The combined use of PRP-therapy, bone grafting or bone impregnated with platelet mass proved to be compatible in osteosynthesis of bone fragments using the Ilizarov apparatus. Conclusion: The use of modern visualization diagnostic tools determines the volume and calculations for filling bone defects.
Isolated subacromial-deltoid bursitis as first manifestation of Brucellosis
Authors: Trabelsi Safa , Khfifi Souha , Amor Rim Ben , Mrad Houcine , Bouomrani Salem
Published: February 2023

Described first by Kennedy JC in 1904, Brucella bursitis remains one of the rarest osteoarticular manifestations during this infection. Its prevalence was only 1-1.2% in wide series but seems to be clinically under-diagnosed. Indeed, its systematic screening by joint ultrasound objectified it in 5.2% of cases in some series. Shoulder bursitis (subacromial, subdeltoid or subacromial-deltoid) remains exceptional and unusual in brucellosis with only few sporadic cases in world literature. This clinical presentation of brucellosis represents a real diagnostic challenge for clinicians. We report an original observation of subacromial-deltoid bursitis as the first manifestation revealing septicemic brucellosis in 21-year-old Tunisian man
Effects of millet based functional foods rich diet on coronary risk factors among subjects with diabetes mellitus: a single arm real world observation from hospital registry
Authors: B Singh Ram , Fedacko Jan , Mojto Viliam , Isaza Adrian , Dewi Mira , Watanabe Shaw , Chauhan Anil , Fatima Ghizal , Kartikey Kumar , Sulaeman Ahmad
Published: February 2023

Introduction: Diabetes mellitus has become a global public health problem, characterized by increased intake of western style diets and decline in physical activities which are pro-inflammatory. Food diversity, nutrient profile, glycemic index and lower content of salt sugar and Tran’s fat are an important consideration for a healthy anti-inflammatory diet which may be advised for prevention of diabetes mellitus and cardiovascular diseases (CVDs). This clinical observation aims to examine the effects of a millets based functional food rich intervention diet on coronary risk factors among subjects with known diabetes. Method: After permission from the review board of a hospital, hospital records of 65 subjects with type 2 diabetes mellitus were drawn for this study. Of 65 patients with diabetes, 5 were excluded and remaining 60 were administered millet-based functional food rich intervention diet (millets 60%, soya bean 20%, brown rice 10%, peanuts 8% and flex seeds 2%). Clinical data, dietary intakes and physical activity were assessed by validated questionnaires. Blood pressures were measured by sphygmomanometer. Result: Treatment with millet based intervention diet for 12 weeks was associated with a significant decline in fasting and 2-hour postprandial blood glucose, HbA1c indicating that this diet can prevent diabetes. Total cholesterol, VLDL cholesterol and triglycerides showed a significant decline compared to baseline levels. Pro-inflammatory cytokines; C-reactive proteins, TNF-alpha and interleukin-6 also showed significant reduction after treatment with intervention diet compared to baseline levels. In association with these changes, there was a significant decline in systolic and diastolic blood pressures, parameters of oxidative stress; TBARS, MDA and diene conjugates with an increase in antioxidant vitamins; A,E and C and beta-carotene. Underlying these changes, all subjects received an 11 fold greater amount of millet-based intervention diet which increased from mean 21.36±3.8g/day to 235.20±23.6 (p<0001).Among females (n=33), there was a significant increase in hemoglobin and serum calcium and magnesium indicating that millet based diet can also prevent under nutrition. Conclusion: It is possible that millet-based intervention diet can cause a significant decline in blood glucose, HbA1c, oxidative stress, blood pressures, blood lipoproteins and pro-inflammatory cytokines with an increase in antioxidant vitamins, magnesium, calcium and hemoglobin. Randomized, controlled intervention trials, would be necessary to confirm our findings.
Forced displacement in Colombia and its international obligations
Authors: Mesa Jaime Alberto Sandoval
Published: February 2023

The historical context of Colombia with more than 60 years of armed conflict (1948 - present) reveals that the phenomenon of forced displacement and migration has occurred in various periods. This phenomenon has not ceased and on the contrary continues to present itself today and therefore represents a significant role in various national and international scenarios, associated both with public policies for its prevention and mitigation and in the prosecution of crimes that are associated with this phenomenon. This article analyzes the various phenomena of migration and displacement and their causes that make it irrepressible at present and that imply new alternative mechanisms of solution, different from punitive repressive aspects. The data is developed through a hermeneutic, analytical and jurisprudential analysis method. For this purpose, the document was prepared using historical, descriptive, teleological and reflective instruments.
The resilience of informal workers to COVID19 and to the difficulties of trade
Authors: Morales Rolando
Published: February 2023

This paper examines the role of the informal labor sector in Bolivia during the pandemic and the confinement contributing to food security. The particularities of this sector in a developing economy and the importance of its networks in its economic, social and political development are explained.
Poverty situation, income and population consumption under the sign of reduction to the essential: Minimum consumption basket
Authors: Mihăilescu Adina
Published: February 2023

At the level of 2019, the poverty in Romania was still very deep. The National Strategy on Social Inclusion and Poverty Reduction (2014-2020) shows that one in five Romanians, poverty caused by insufficient income, and much of the poverty caused by low income is persistent. Three quarters of the poor are has been in this situation for at least three years. Also, a third of the population cannot afford to buy products or services considered desirable or even necessary to live a decent life. According to the same document, there are still children who have never been to school, and the percentage of young people without a proper education is high. Many people are inactive or formally unemployed, with little chance of gaining adequate access to the labor market, and that there are inequalities in coverage with basic health services. The largest categories include children in difficult situations, people with disabilities, single or dependent elderly people and the Roma, who number three million people, but the estimated population as poor or vulnerable is about five million people.
The internal tensions of Political Correctness in the Brazilian context
Authors: Bettine Marco
Published: February 2023

This article presents a reflection on the constitutive aspects of Political Correctness (PC). It utilizes the idea of double decontextualization developed by Norman Fairclough, to discuss the process within the PC action operates. With this framework, and the presentation of examples, the article seeks to point out that the PC criticism develops in two senses: (i) by literally interpreting the linguistic expression and (ii) an attempt to hide the subject agent of the action of criticism behind the universality of the defended value. In this sense, the strength of the PC is linked to a double decontextualization movement.
The difficulty of understanding the meaning of words in sacred texts by the individual and the dangers induced in the social field
Authors: Abdellaoui Abdelkader
Published: February 2023

This article starts from the observation of contradiction between a religious conviction and its practice in social life. To try to understand this contradiction, he introduces the concepts of social influences, then the ability to interpret words and expressions in texts and in their socio-cultural, political and economic context. The notion of interpretation is not limited to words, but extends more generally to the ways of thinking and culture of the time when the text was written. The question is how would be written today what was written in a given historical period, in a given socio-cultural, political, economic, scientific knowledge context. The notion of appropriation of authority is also briefly reviewed to show how the individual (the believer in this case) transforms himself into a kind of defender of his belief and to this end states postulates or attitudes, instead of texts, on what should or should not be done. We wonder whether the cause is ignorance or unconsciousness or any desire to impose oneself.
Comparison of depression, suicidal thoughts and social support between transsexuals with and without gender change
Authors: Ashkeftaki Asma Naderi
Published: February 2023

Objectives: Social acceptance of people with gender identity disorder in society is very difficult and this condition can lead to depression and suicidal thoughts. On the other hand, social support has a great impact on the psychological factors of these people. Therefore, this study was conducted with the aim of comparing depression, suicidal thoughts and social support between transsexuals with and without gender change. Instruments & methods: This descriptive research of causal-comparative type was conducted among 60 members of transsexuals with gender change (30 people) and without gender change (30 people) of Iran's Association for the Support of Gender Bored Patients, who were selected by available sampling method. and completed the Beck depression, Beck suicidal thoughts and Sherbon and Stewart social support questionnaires. Data analysis was done by SPSS 24 software and using multivariate analysis of variance test. Findings: The mean scores of the variables of depression and suicidal thoughts in the transsexual group without gender change were higher than the transsexual group with gender change, but in the variable of social support, the transsexual group with gender change had a higher average score. There was a significant difference between the two groups in terms of suicidal thoughts and social support variables (p=0.01), but no significant difference was observed in terms of depression variable (p>0.0). Conclusion: In both groups of transsexuals with and without gender reassignment, there is a moderate level of depression and suicidal thoughts, but transsexuals without gender reassignment have more suicidal thoughts and transsexuals with gender reassignment are more likely to seek social support.
Labour migration: a socio-cultural factor for social transformation in Banke district, Nepal
Authors: Tharu Diapk
Published: February 2023

This study deals with labour migration as a sociocultural factor to transform society and improve human livelihoods. It explores how social transformation is reshaping social systems, social identities, social patterns and practices. Labour migration has been a top choice and household strategy for improving living standards and social status. This study responds to how labour migration is affecting local ethnic communities, in particular, Tharu communities, and how the process of social transformation is restructuring social practices, social identities, social values and norms. This study primarily uses qualitative methods to gain a deeper understanding of the social transformation restructuring social, cultural and political aspects in the Tharu community. It approaches social transformation to examine the later social structures and human mobilities. The findings clearly show the processes of social transformation reforming the residents’ living standards through the receipts of remittances and technological goods and services. Social identities are also reformed with a realisation of social integration. The socioeconomic status of the migrants’ families has significantly improved. In addition, the existing social practices namely Kamaiyas (Bonded Labourers) and Sukumbasi (Slums) are removed from the Tharu communities. This study can contribute to the government and non-government-led development programs and projects as well as implement new policies and strategies to address migration-related issues in contemporary societies of Nepal and indeed in other regions of the world.