bluuebunny/crossref_metadata_2025 huggingface dataset:
Spectrum of Adjacency Matrix of Graphs in Cryptography
Authors: Pragathi Krishnaprabha.R
Published: May 2023

Having access to an elliptic curve with a specified number of points over a specific finite field isa prerequisite for many contemporary cryptography systems. The isogenies, which are surjectivemorphisms, play a significant role as specific mappings between these curves. Isogeny volcanoesare graphs with elliptic curves as their vertices and l-isogenies as their edges. Two identical ellipticcurves over Fq share the same trace t and cardinality. David Kohel examines the relationshipsbetweenisogenies of degreel and curves in Ellt(Fq ), the collection of curves defined over Fq withtrace t, in his thesis. More precisely, he describes the structure of the graph of l-isogenies definedon Ellt(Fq ).There is a relation between Isogeny graphs and orders in OK and uses modular poly-nomials to find the conductor of End(E). The connected components of this graphs are isogenyvolcanoes and it is possible to travel through these structures using modular polynomials, evenwithout knowing the cardinality of the curve.By using this information computation of the l-adicvaluation of the trace t, for l|g possible and hence obtain some information on the cardinality of thecurve. Isogeny graphs of supersingular elliptic curves plays a major role in cryptography.Isogenybased cryptography, studies cryptosystems whose security is based on the difficulty of finding apath in isogeny graphs of supersingular elliptic curves. This study investigates the use of graphadjacency matrices in maintaining the security of isogeny based key exchange protocols.
Research on the Motivation and Path Simulation of Collaborative Agglomeration of Chinese Culture and Tourism Industries Based on System Dynamics
Authors: Chi Yihan , Fang Yongheng , Liu Jiamin
Published: May 2023

This article is based on the dynamic system of collaborative agglomeration between culture and tourism industry, and uses a system dynamics model to explore the development path of collaborative agglomeration between Chinese culture and tourism industry. The results show: (1) Although China's shared collaboration between the cultural and tourism industries continues to increase year by year, this status quo development path is still considered slow. (2) Under the policy support path, the degree of collaborative agglomeration between China's cultural and tourism industries continued to increase year by year; however, after 2018, this path played a more significant role in promoting their development. (3) Under the economic support path, the degree of these industries’ agglomeration collaboration increased annually; however, after 2018, the growth rate gradually slowed down. (4) The policy-economic combination path has had the best promotion effect based on the cultural and tourism industries’ coordinated agglomeration development.
Technological Phases of Quantum Technologies Driving Long-Term Development
Authors: Coccia Mario , Roshani Saeed
Published: May 2023

The goal of this study is to develop a technology analysis for examining the evolutionary phases of some critical quantum technologies to explain on-going technological development. Method applies S-shaped model based on logistic function that is estimated with patent data to analyze the phases of quantum technologies over the course of their technological evolution. Findings reveal that the technological cycle of recent quantum technologies has a shorter period in emergence phase and a longer period in growth and maturity phases than older quantum technologies. In particular, structure of technological cycle also shows that for quantum technologies originated after 1980, technological phase of emergence (to reach to the point of growth) is reduced to 52% of the total length of the cycle, compared to 68% of technologies originated before 1980, whereas the growth and maturity phases for technologies originated after 1980 have a higher percentage weight on the total duration of the cycle than technologies originated before 1980: growth stage is 22.78% of total duration of cycle in new technologies originated after 1980 vs. 15.76% in older technologies originated before the 1980; maturity stage is 25.32% vs. 16.08%, respectively of total technological cycle. Results here can provide theoretical implications to explain dynamics and structure of the technological evolution of emerging quantum innovations that support the technological forecasting for improving decisions of R&D investments in specific technologies that can be major sources of next technological, industrial, economic and social change.
Evaluation of Myocardial Strain in Patients With Subclinical Hypertrophic Cardiomyopathy and Subclinical Hypertension Heart Disease Using Cardiac Magnetic Resonance Feature Tracking
Authors: Hao Xiaoyong , Wu Jiang , Zhu Lina , Li Xuan
Published: May 2023

The evaluation of cardiac magnetic resonance feature tracking may have great diagnostic value in hypertrophic cardiomyopathy and hypertension heart disease.To explore the diagnostic and clinical research value of cardiac magnetic resonance feature tracking in evaluation of myocardium deformation in patients with subclinical hypertrophic cardiomyopathy(SHCM)and subclinical hypertension heart disease(SHHD).CMR scans was performed on 1.5 T MR scanner in 33 patients with SHCM,31 patients with SHHD, and 27 controls(NS).The CMR image post-processing software was used to analyze the characteristics of routine cardiac function, different global and regional myocardial strain in each group.Analysis of variance (ANOVA) was used to compare age, blood pressure,heart rate,routine cardiac function,body mass index (BMI), as well as the strain between different segments within each of the three groups. If a significant difference was detected, a least significant difference (LSD) comparison was performed if there was a significant difference.The diagnostic efficacy of different parameters in differentiating SHHD from SHCM was evaluated through receiver operating characteristic (ROC) curve analysis, and determination of the best cutoff value.The routine cardiac function parameters were no statistically different among three groups (P＞0.05).There are statistical differences between the global myocardial strain parameters and the peak strain parameters of some segments,especially the basal segment, in each group (P＜0.05), and the Global radial peak strain(GRPS) can be used to distinguish SHCM from SHHD group (The area under the ROC curve was 0.885), which is the best diagnostic performance.Cardiac magnetic resonance feature tracking can detect left ventricular deformation in patients with SHCM and SHHD group.The abnormality of strain has important research value for its subclinical diagnosis and clinical evaluation.
Influence of Yb3+ ION Percentage on the Emission of Er3+ ION Doped Into GdVO4 Matrix
Authors: Ferreira Maria Fernanda , Faria João Vitor Gonçalves , Pontes Lauany Mazzon , Crespi Marcela Guedes Matos , Rocha Lucas Alonso , Nassar Eduardo José
Published: May 2023

In this study the non-hydrolytic sol gel methodology was used to synthesized gadolinium vanadate particles doped with different molar ratios of the Er3+ and Yb3+ ions. The sol gel synthesis, lanthanide ion chlorides and vanadium alkoxide were used as precursors. The resulting powders were treated at 800 oC and characterized by X-ray diffraction and photoluminescence properties. The X-ray diffractogram displayed peaks attributed to the gadolinium vanadate matrix. Photoluminescence helped to evaluate the Fluorescence Intensity Ratio (FIR), parameter for understanding the nanothermometer property. The FIR of the GdVO4: Er3+/Yb3+ samples containing different molar ratios of the Er3+ and Yb3+ ions increased as a function of laser power, which indicated that the local temperature increased. The excitation spectra obtained at fixed wavelengths of 525 and 555 nm displayed bands at 322, 379, and 489 nm, ascribed to the charge transfer band and Er3+ ion levels. Upon excitation at 322 nm, the emission spectra in the visible region presented intense bands at 525 and 555 nm, due to Er3+ ion emission, and excitation at 322 nm, the emission in the infrared region, 980 and 1550 nm, were observed. The system is a candidate can be employed as temperature sensor.
Integrally Private Model Selection for Deep Neural Networks
Authors: Varshney Ayush K. , Torra Vicenç
Published: May 2023

Deep neural networks (DNNs) are one of the most widely used machine learning algorithm. In the literature, most of the privacy related work to DNNs focus on adding perturbations to avoid attacks in the output which can lead to significant utility loss. Large number of weights and biases in DNNs can result in a unique model for each set of training data. In this case, an adversary can perform model comparison attacks which lead to the disclosure of the training data. In our work, we first introduce the model comparison attack for DNNs which accounts for the permutation of nodes in a layer. To overcome this, we introduce a relaxed notion of integral privacy called $\epsilon$-integral privacy. We further provide a methodology for recommending $\epsilon$-Integrally private models. We use a data-centric approach to generate subsamples which have the same class-distribution as the original data. We have experimented with 6 datasets of varied sizes (10k to 7 million instances) and our experimental results show that our recommended private models achieve benchmark comparable utility. We also achieve benchmark comparable test accuracy for 4 different DNN architectures. The results from our methodology show superiority under comparison with three different levels of differential privacy.
YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression
Authors: Xiao Yao , Zhou Lilni , Andl Thomas , Zhang Yuhang
Published: May 2023

Epithelial-to-mesenchymal transition (EMT) is crucial for melanoma cells to escape keratinocyte control, invade underlying dermal tissues, and metastasize to distant organs. The hallmark of EMT is the switch from epithelial cadherin (E-cadherin) to neural cadherin (N-cadherin), allowing melanoma cells to form a homotypic N-cadherin-mediated adhesion with stromal fibroblasts. However, how “cadherin switching” is initiated, maintained, and regulated in melanoma remains unknown. Here, we show that upon Yes-associated protein 1 (YAP1) ablation in cancer-associated fibroblasts (CAFs), the progression of a BRAF-mutant mouse melanoma was significantly suppressed in vivo, and overexpressing YAP1 in CAFs accelerated melanoma growth. CAFs require YAP1 function to proliferate, migrate, remodel the cytoskeletal machinery and matrix, and promote cancer cell invasion. By RNA-Seq, N-cadherin was identified as a major downstream effector of YAP1 signaling in CAFs. YAP1 silencing led to N-cadherin downregulation in CAFs, which subsequently induced the downregulation of N-cadherin in neighboring melanoma cells. N-cadherin downregulation inhibited the PI3K-AKT signaling pathway in melanoma cells and suppressed melanoma growth in vivo, supporting the role of N-cadherin as an adhesive and signaling molecule in melanoma cells. This finding suggests that YAP1 depletion in CAFs induces the downregulation of p-AKT signaling in melanoma cells through the N-cadherin-mediated interaction between melanoma cells and CAFs. Importantly, our data underscore that CAFs can regulate N-cadherin-mediated interactions with melanoma cells. Thus, disentangling cadherin-mediated cell‒cell interactions can potentially disrupt tumor-stroma interactions and reverse the tumor cell invasive phenotype.
Photobiocatalytic Conversion of Solar Energy to NH3 from N2 and H2O
under Ambient Condition
Authors: Ohsaki Yutaka , Shen Xiao-feng , Watanabe Motonori , Song Jun Tae , Ishihara Tatsumi , kosem Nuttavut
Published: May 2023

Several methods and catalysts have been investigated for eco-friendly ammonia (NH3) production under mild conditions in the past few decades. NH3 is important chemical fertilizer and now expecting as H2 carrier, and mainly synthesized by Haber-Bosch process under severe conditions (400 ℃, 20MPa). In contrast, nitrogenases, biocatalyst can activate N2 and H2O to form NH3 under ambient conditions in nature with a low synthesis rate. Herein we first reported photobiocatalytic NH3 production by the combination of cyanobacterial Anabaena variabilis as a whole-cell biocatalyst coupled with TiO2 as a photocatalyst in the existence of glycerol as a sacrificial reagent and viologens as an electron transfer mediator. Comparing with natural system, the formation rate of NH3 from a combination with inorganic photocatalyst was much increased by ca. 20.86 times. Biocatalytic reactions revealed that only reduced MV•+ passed into whole cells and transfer electrons to nitrogenase efficiently for NH3 production. The amount of intracellular [MoFe]-nitrogenase was increased in cyanobacteria cultivated in a nitrogen-deficient Allen & Arnon medium. The complete hybrid system produced NH3 with a maximum rate of 3.3 µM·g-1·h-1. This study is the first demonstration of the sustainable technology for solar-to-NH3 conversion as an energy carrier for a future carbon-neutral energy society.
Phytochemical profiling and GC-MS analysis of methanol extract of Spinifex littoreus(Burm. f.) Merr
Authors: Purushothaman Ramamoorthy , Vishnuram Ganapathy , Ramanathan Thirugnanasambandam
Published: May 2023

Coastal sand dune plants are of great importance to researchers in the field of pharmacology, medicinal, industrial, nutritional, and ecosystem restoration. Nowadays most of the pharmaceutical industries depend on the medicinal plant for their raw materials for drug discovery. Spinifex littoreus is a coastal plant under the family Poeaceae growing on the sandy seashore and is well known for its medicinal properties. The present study was carried out to the phytochemical screening and estimated the bioactive components present in the methanolic extract of Spinifex littoreus leaves. The phytochemical studies revealed the presence of flavonoids, saponins, alkaloids, terpenoids, tannins, and phenols. The GC-MS analysis revealed the presence of twenty bioactive compounds which include n-Hexadecanoic acid, 9,10-Secochola-5,7,10(19)-trien-24-al, 3-hydroxy-(3.beta.,5Z,7E), and 1,3-Benzenedicarboxylic acid, etc., The phytochemical and GC-MS profiling of the methanol extract of Spinifex littoreus leaves revealed the presence of bioactive compounds with important medicinal properties. Hence, the presence of these phytochemicals could be responsible for the therapeutic effects of the plant.
Rhizosphere microbial community dynamics contribute to nitrogen fixation and forage quality in novel perennial intercrops in Rwanda
Authors: Schaedel Marie , Majuga Jean Claude Noel , Ishii Satoshi , Jungers Jacob , Paul Birthe , Mutimura Mupenzi , Mwendia Solomon
Published: May 2023

In low-fertility tropical agroecosystems, intercropping with perennial legumes has the potential to maximize biological nitrogen fixation (BNF) and improve non-legume nitrogen (N) uptake and yields. However, the microbial interactions that facilitate the beneficial effects of intercropping in perennial systems remain largely uncharacterized, particularly in the tropics. In this study, we explored the contribution of root-associated bacteria and fungi to N content and the nutritional characteristics of perennial grasses (Cenchrus purpureus and Brachiaria cv. Mulato II) and an annual cereal (Zea mays) intercropped with a perennial legume (Desmodium sp). Sampling approximately every 8 weeks at the time of forage grass anthesis, we collected biomass leaf tissue, bulk soil, and rhizosphere soil. We calculated nitrogen derived from the atmosphere (Ndfa) in Desmodium leaf tissue to estimate BNF and found that Ndfa increased in intercropping arrangements relative to single-cropped Desmodium by 91.6–147.1% on average in intercropped stands with Brachiaria and C. purpureus. Intercropping also induced positive changes in non-legume tissue quality in a species- and site-dependent manner. Furthermore, we identified microbial taxa that were significantly enriched in the rhizosphere of intercropped plants relative to monocropped plants and which correlated to multiple forage nutritive quality metrics. Fungal community structure responded more strongly to the presence of a legume intercrop than bacterial communities. We also identified species-specific trends in the degree to which monocropped and intercropped rhizosphere communities differed. Overall, this study suggests that perennial legume intercropping may recruit beneficial rhizosphere microorganisms in rainfed tropical soils to facilitate nutritional benefits in the non-legume companion crop and highlights the complexity of rhizospheric microbial interactions in intercropped systems.
The shipyard technological level evaluation methodology
Authors:   Tehnička škola Rijeka, Rubeša Rajko , Hadjina Marko , Matulja Tin , Bolf Davor
Published: May 2023

A competitive advantage over other shipyards is extremely important in the high-stake shipbuilding industry. Typically, a competitiveness analysis of a shipyard measures productivity based on specific parameters, such as tonnes or compensated gross tons produced per consumed working hour. The authors of this paper consider identifying the technological level required to achieve this productivity as essential, including other information relevant for the shipbuilding process. Therefore, a methodology for determining the technological level of shipyards is proposed based on defined criteria and a structured evaluation. The criteria were devised and structured hierarchically. The methodology also offers company management a solution for continuous monitoring for improving shipyard design and production processes.
SHORT TERM EFFECT OF INTRAVENOUS FLUID THERAPY IN PAEDIATRIC INTENSIVE CARE UNIT ON SERUM ELECTROLYTES AND RENAL FUNCTION TESTS OF CHILDREN
Authors:   Department of Paediatrics, ByramjeeJeejeebhoy Government Medical College, Pune, Maharashtra, India., V. Mavchi Snehal , D. Sonkawade Naresh ,   Department of Paediatrics, ByramjeeJeejeebhoy Government Medical College, Pune, Maharashtra, India., Deshmukh Isha ,   Department of Paediatrics, ByramjeeJeejeebhoy Government Medical College, Pune, Maharashtra, India., M. Dawre Rahul ,   Department of Paediatrics, ByramjeeJeejeebhoy Government Medical College, Pune, Maharashtra, India., A. Kinikar Aarti ,   Department of Paediatrics, ByramjeeJeejeebhoy Government Medical College, Pune, Maharashtra, India.
Published: May 2023

Background: Studies have shown that using hypotonic fluids may result in hyponatremia and the use of isotonic fluids is associated with lower incidence of electrolyte disturbances. Renal functions usually based on measurements of serum urea and creatinine are dependent on the maintenance of appropriate intravascular volume in order to maintain adequate organ perfusion and functioning. Aims and Objectives: To analyze the short term effect of IV Fluids in PICU on serum electrolytes and renal function tests. Methods: This observational descriptive study was conducted in 125 children admitted PICU from April 2022 to September 2022 receiving IV fluids and kept nil by mouth. The levels of serum sodium, potassium, urea and creatinine done at day1 of admission were compared to the investigations done after 72hrs.The data was categorized based on the type of fluid received by the child. Hypotonic fluids (0.45% DNS, D10) and isotonic fluids (0.9% DNS). Results: Out of 125 children, 61(48.8%) received hypotonic fluids whereas 64(51.2%) received isotonic fluids. The average volume of hypotonic fluid given was 3.2Â±1.7 ml/kg/hr whereas of isotonic fluid given was 2.7Â±1.3 ml/kg/hr (p=0.11). Hyponatremia developed in 16 out of 42 baseline normal sodium patients in hypotonic group and 6 out of 46 in isotonic group(p=0.03). Serum creatinine was raised in 6(12%) patients out of 50 baseline normal patients in hypotonic group. Serum urea from baseline normal was raised in 7(21.9%) in hypotonic and in 5(17.9%) in isotonic group (p=0.4). Mortality was significantly higher in hypotonic group (13.1%) compared to isotonic group (3.1%) (p=0.04). Conclusions:For preventing positive fluid balance and also development of hyponatremia, isotonic fluids should be considered as routine maintenance fluids.
TÜRK BORÇLAR KANUNU KAPSAMINDA ESER SÖZLEŞMESİNDE AYIP SEBEBİYLE SORUMLULUK
Authors: SÜRER Metin , DEMİR Bahadır
Published: May 2023

Eser sözleşmesi TBK 470 vd. hükümlerinde düzenlenmiştir. Kanundan hareketle eser sözleşmesinde yüklenici, maddi ya da gayri maddi bir varlığı olan bir eser meydana getirmekte, alıcı ise bu edime karşılık ücret ödeme borcu altına girmektedir. İşgörme sözleşmelerinin bir türü olan eser sözleşmelerinde edim sonucuna yönelik taahhüt, bu tür sözleşmelerin ayırıcı unsurudur. Eser sözleşmesinde yüklenici, ücret karşılığında bir eseri meydana getirmek ve meydana getirmiş olduğu eseri teslim etmek hususlarını işsahibine borçlanmaktadır. Eser sözleşmelerinde yüklenicinin borçlarından birisi ise ayıba karşı tekeffül borcudur. Ayıba karşı tekeffül borcu, işsahibinin sözleşmede meydana getirilmesi kararlaştırılan eserin kusursuz ve eksiksiz olmasına ilişkin menfaatini korumaktadır. Ayıptan doğan sorumluluk hükümleri birçok hâlde teslimden sonra gündeme gelmekle beraber, bazı durumlarda teslimden önceki aşamalarda da uygulama alanı bulmaktadır. Yüklenici, eserin ayıplı olması durumunda, Kanunda öngörülen şartların sağlanması kaydıyla, eserdeki ayıptan sorumlu olur. Kanunkoyucu, eserin ayıplı olması durumunda alıcıya; sözleşmeden dönme, bedelde indirim ve onarım seçimlik haklarının yanısıra tazminat hakkı da tanımaktadır. Aşağıda ayıptan doğan sorumluluğun şartları ve sonuçları sırası ile incelemeye tabi tutulacaktır.
DIFFUSION STUDY OF NaCl AND KCl AT THE SOLUTION/OLIVE INTERFACE: MATHEMATICAL MODELING USING THE FINITE ELEMENT METHOD AND SELF-ORGANIZING FEATURE MAP (SOFM)-TYPE NEURAL NETWORKS
Authors: Borsato Dionisio , Clemente Marco , Silva Heloisa , Silva Nathan , Campos Julia , Sousa Eduardo , Silva Hágata , Angilelli Karina , Mantovani Ana , Mantovani Rafael
Published: May 2023

Olive samples were subjected to the salting process in brine containing 1196 mol m-3 of NaCl and 402 mol m-3 of KCl. Samples were collected during 60 h and salt concentration values were determined. With the finite element method (FEM) and the minimization of the errors percentage between the simulated and experimental values, the mass transfer coefficients in the film (hm) were obtained, being 1.0072 × 10-8 and 1.2499 × 10-8 for NaCl and KCl, respectively. The salts concentration at the olive/brine interface was simulated by FEM and analyzed via SOFM. A network with 4 × 4 topology and 10000 training epochs was used. It was observed that the influence of the stationary film formed on the surface of the olives during the salting process depends on the position, the salt involved in the diffusion and that the concentration of the salts, at each point, varies according to the immersion time.
French Constitutional Court's control over French finance law
Authors:   European Constitutional Law Association, Han Dong Hoon
Published: May 2023

The French Constitutional Court has reviewed most of the finance laws. The control of the French Constitutional Court can be divided into ⅰ) control under Article 40 of the French Constitution, ⅱ) control of legal regulations unrelated to the purpose of finance laws, ⅲ) control of discussion procedures in parliament, and ⅳ) control of the contents of finance laws. France's current finance laws should not just be an expression of the general will of the people, but also comply with the constitutional order prescribed by the Constitution of the Fifth Republic of France. The attitude of the French Constitutional Court to control finance laws needs to be actively reviewed and accepted in discussions for the introduction of legislation- based budget system, especially in the specific design of the constitutional amendment. Therefore, in the case of introducing legislation-based budget system through constitutional amendment, the enactment of finance laws should not be discussed only in terms of the distribution of power between the parliament and the government, and the Constitutional Court's control over finance laws should also be guaranteed.
A study on German public transportation legislation
Authors:   European Constitutional Law Association, Hong sunki
Published: May 2023

The right to transportation means the right of all citizens to move freely and safely regardless of economic, regional, physical, or social conditions. This, of course, includes the right to use public transportation and the right to move for the transportation vulnerable. Regarding public transport legislation as part of the right to transport, Germany is often cited as the country with the most well-established public transport system in Europe. The characteristics of Germany's public transport legislation can be summarized as follows. First, the German public transport legislation is responding quickly to the trend of the times. Second, public transport policy in Germany is, in principle, under the jurisdiction of the cantons. Third, the provision of financial support in German public transport laws is essential. Fourth, public transportation in Germany is integrated and maintained. Fifth, the German public transport law guarantees the right to move for the disabled. In order for all citizens to enjoy a universal level of transportation service, the right to transportation must first be a fundamental right guaranteed by the Constitution. Based on this, a full-scale review of public transportation-related laws and regulations should be conducted. The case of Germany gives us many suggestions in this respect.
Vibration reduction design for a shared bearing bore of a turboshaft engine
Authors: Lu Yu , Tang Zhen Huan , Wang Fei
Published: May 2023

The traditional dynamic analysis of the finite element structure is mostly focused on the mode analysis. In the paper, the finite element method is combined with the power flow analysis to analyze and optimize the vibration transmission characteristics of the shared bearing bore, so that the vibration energy transmitted to the mounting flange is minimized. The analysis shows that the elastic ring and the outer case play an important role in vibration transmission and reduction. An optimization model is established to improve the vibration reduction rate of the shared bearing bore. The results show that the optimization can effectively improve the vibration reduction rate of the shared bearing bore, approximately 15 % reduction of peak response is achieved.
Influence of an external alternating electromagnetic field on convective flows in the bath of an ore-thermal furnace during the melting of oxide refractory materials
Authors: Abdrakhmanov Yerkesh , Kalimbetov Galym
Published: May 2023

Electric arc melting of oxide materials under the influence of an external electromagnetic field is a high-current and high-temperature technological process, accompanied by powerful electric and magnetic fields and complex structural motion of the melt. In the general case, the movement of the melt in the bath of an electric arc installation is determined by a combination of thermocapillary, thermal concentration, thermal and electromagnetic convections. In this work, based on the analysis of convective flows and the calculation of the integral vortex field of Archimedes forces and electromagnetic forces in the bath, using the OKB-2126A ore-thermal furnace for melting oxide refractory materials as an example, an assessment of thermal and electromagnetic convections was carried out. For the first time it has been established that the value of the integral vorticity of the field of electromagnetic forces in the depth of the bath exceeds the integral vorticity of the field of Archimedes forces by 3-4 times. In real objects, this difference is even greater, since, compared to those accepted in the calculations, the actual current density in the bath is higher, and the temperature difference is lower. Thus, electromagnetic convection in ore-thermal furnaces for melting oxide materials significantly exceeds thermal convection and makes a decisive contribution to the formation of the structure and intensity of melt movement.
The effect of an osmotic crystalline surface protectant agent on the performance of cement fly ash stabilized Aeolian sand bases
Authors: Sun Changfeng , Wang Ke
Published: May 2023

This paper studies the use of cement fly ash to stabilize the graded gravel and the use of aeolian sand instead of fine aggregates in the design of mixture composition. Firstly, the effect of different cement-fly ash ratios on the aeolian sand bases was investigated, and then the synergistic effects of osmotic crystalline surface protectant (OCSP) and different cement-fly ash ratios on the mechanical properties and water-blocking properties of aeolian sand were analyzed. The results indicated that the optimal water content and maximum dry density of the mixture are increased and the unconfined compressive strength of the 7 d and 28 d both is downward by fly ash. The unconfined compressive strength of the aeolian sand base treated by OCSP was significantly improved, and the enhancement effect was more significant with the increase of cement content. The water absorption rate of each group of specimens increased rapidly during the first 10 hours of immersion., However, the water absorption rate of the specimen treated with OCSP was almost zero in the whole water absorption process after 10 hours.
An empirical formula for the accumulative deformation of saturated clay under different cyclic loading frequencies
Authors: Bu Qiang , Zhou Ying , Zhou Yang , Wang Liang , Qin Lisheng , Yang Mingjie
Published: May 2023

Road and subway tunnels in soft clay soils subjected to traffic loading often cause lager settlement. It can pose danger to the surrounding buildings and structures. Hence, it is necessary for engineers to correctly predict the long-term deformation of saturated clay foundations under cyclic loading. In this paper, a series of dynamic triaxial tests were carried out on Nanning clay to investigate the effect of loading frequency and cyclic stress on axial strain accumulation of clay under undrained condition. Results show that loading frequency has a great effect on the axial strain accumulation of clay. Based on the experimental results, an empirical formula for calculating the accumulated deformation of saturated clay under cyclic loading was presented.
Uncertain optimization for composite base plate of mortar under impact load
Authors: Wang Fengfeng , Yang Guolai , Xu Fengjie
Published: May 2023

Information warfare places higher requirements on the remoteness, precision and mobility of artillery weapon systems. As an indispensable and important category of artillery, mortar plays an important role. As an important component of mortar, the base plate bears tremendous impact load. Its design level has an important influence on the shooting stability, shooting accuracy and maneuverability of the mortar. Composite base plate helps improve the maneuverability of the mortar, but it will also make the force and movement rule of mortar launching more complex and lead to a more acute contradiction between artillery power and maneuverability, which propose a huge challenge to modern artillery optimization design theory. Under this background, this manuscript conducts research on the structural uncertain optimization of composite material base plate for the mortar. In order to obtain the optimal solution and reasonable interval of uncertain parameters with main dimension parameters, this manuscript uses interval model to carry out deterministic transformation for uncertain objective function and uncertain constraints, combines multi-objective genetic algorithm to solve the problem, and carries out numerical simulation to verify the optimal value. The result shows that the design idea and method are feasible for uncertain optimization of composite base sheet of mortar under impact load, and the optimization objectives and strategies are effective, which can provide reference for the uncertain optimization research of composite base plate.
On attractors in systems of ordinary differential equations arising in models of genetic networks
Authors: Kozlovska Olga , Sadyrbaev Felix
Published: May 2023

Two three-dimensional systems are considered, which have solutions with irregular behavior, tending to attractors. The comparison and comparative analysis are made
Numerical analysis of random vibration fatigue for a typical airborne equipment
Authors: Wang Man
Published: May 2023

In this paper, the fuel pump impeller was selected as a typical airborne equipment for the investigation of random vibration fatigue. First, based on the platform of ANSYS WORKBENCH, the reasonable calculation of FSI for the impeller was carried out. Then, the stress was transferred to modal analysis, and the prestress-structure modal was extracted. Through random vibration response analysis, the stress of the impeller was obtained. The Palmgren and Miner rule and Dirlik fatigue calculation method was used to calculate fatigue life, and the result was consistent with practice. The work in this paper provided a method about how to obtain random vibration fatigue life with prestress-structure, which was critical references for aviation technologists.
Achillea millefolium (Civanperçemi) Bitkisinin Uçucu Yağlarının Antimikrobiyal ve Antifungal Etkinliğinin Değerlendirilmesi
Authors: ZÖNGÜR Alper
Published: May 2023

Tıbbi aromatik bitkiler binlerce yıldır ilaçların ana kaynağı ve sistematik geleneksel ilaçların temeli olarak kullanılmaktadır. Tıbbi aromatik bitkiler arasında çeşitli hastalıkların tedavisinde en yaygın kullanılan bitkilerden birisi Asteraceae familyasında bulunan Achillea sp. türleridir. Achillea türlerinin en bilinen bitkisi A. millefolium’dur. A. millefolium çeşitli cilt rahatsızlıklarını ve sindirim bozukluklarını tedavi etmek için kullanılır. Tıbbi kullanımlarına ilaveten kozmetik ve veterinerlik alanında da kullanılmaktadır. Monoterpen 1,8-sineol iyi bilinen bir terpenoit oksittir ve ayrıca klinik etki için ilgili bir anlamı olan diğer uçucu yağların bileşenidir. Anti-inflamatuar, antioksidan, serbest radikal süpürücü, mukolitik/sekretolitik, bronkodilatör, antiviral ve antimikrobiyal etkileri de dâhil olmak üzere birçok biyolojik aktivitesi bilinmektedir. Bu çalışma, Sivas’ta yetişen Achillea millefolium (civanperçemi) bitkisinin uçucu yağ bileşimi miktarını değerlendirmek amacıyla yapılmıştır. Çalışmada bitkinin uçucu yağ içeriği tespit edilmiş ve 1,8-sineol (%19.33) bileşiğinin Achillea millefolium bitkisinde bulunan diğer uçucu yağlardan yüksek olduğu belirlenmiştir. Çalışmalarda, bitki uçucu yağı analizi için Gaz Kromatografisi (GC-MS) kullanılmıştır. Bitkide, baskın olarak 15 adet uçucu yağ bileşeni belirlenmiştir ve yazımızda detaylı olarak sunulmuştur. Ayrıca, bitki uçucu yağının antimikrobiyal ve antifungal özelliği belirlenmiştir. Escherichia coli, Staphylococcus aureus, Salmonella typhimurium türlerinin inhibisyon çapları sırası ile 0.891, 0.763 ve 0.529 mm olarak bulunmuştur. Benzer şekilde, Aspergillus flavus, Fusarium solani ve Penicillium digitatum karşı uçucu yağın engelleme oranı sırasıyla %34.91, %21.47 ve %23.08 olarak bulunmuştur.
Adipoz Doku Kaynaklı Ekstrasellüler Veziküllerin Meme Kanseri Hücreleri Üzerine Apoptotik Etkisi
Authors: KAAN Dilek
Published: May 2023

Meme kanseri, en yaygın küresel malignitedir ve kansere bağlı ölümlerin ikinci önde gelen nedenidir. Meme kanserinin erken teşhis edilmesi, farklı tedavi yöntemleri ile tedavi başarı oranını yükseltmektedir. Ancak ilerleyen evrelerde ise hem tedavi başarı oranı düşmektedir hem de güncel tedavi yöntemlerinden kemoterapi veya radyoterapinin uygulanmasının hastaya yan etkileri de olabilmektedir. Bu nedenle kişiye özel, yan etkinin olmadığı tedavi modellerini bulmak gerekir. Eksozomlar doğal nanopartiküller olup, aynı zamanda hücreler arası iletişimde önemli roller oynayan, çok çeşitli lipidler, proteinler, metabolitler, RNA'lar ve DNA'lar içeren küçük hücre dışı veziküller olarak bilinirler. Bu çalışmanın amacı, adipoz doku kaynaklı mezenkimal kök hücrelerden presipitasyon yöntemi ile elde edilen eksozomların (ADEkso) insan meme kanseri hücre hattı, MCF-7, ve meme epitel hücre hattı, MCF10A, üzerinde farklı konsantrasyonlarda Anneksin V/PI metodu kullanılarak apoptotik etkilerinin araştırılmasıdır. Erken apoptotik, geç apoptotik, canlı ve ölü hücreler, her iki hücre hattında 24, 48 ve 72 saat boyunca farklı 40x1010, 20x1010 ve 10x1010 AD-Ekso/mL konsantrasyonları ile muamele edilerek MCF-7 gruplarında toplam yüzde total apoptotik etkileri 24 saat için 40x1010/AD-Ekso/mL’de %58.817±4.2, 48 saat için 0x1010/AD-Ekso/mL 'de %56.37±9 ve 72 saat için 20x1010 AD- Ekso/mL'de %70.9±4.1'dir. AD-Ekso verilen MCF-7 hücre grupları hem kendi aralarında hem de AD-Ekso uygulanmayan MCF-7 hücre grupları ve MCF10A hücre grupları ile karşılaştırıldığında zaman ve doza bağlı olarak aradaki fark istatistiksel olarak anlamlı bulunmuştur (p˂0.05). MCF10A ve MCF-7 kontrol grupları değerlendirilmiş ve anlamlı bir fark gözlenmemiştir (p˃0.05). Sonuç olarak, eksozomlar kanser hücrelerinde apoptozu indükleyerek kanser tedavisinde potansiyel kapasiteye sahip olabilir
Laktik Asit Bakterilerinde Tetrasiklin Direncinin Fenotipik ve Tüm Genom Dizilerinde in silico Genotipik Olarak Araştırılması
Authors: ILIKKAN Özge
Published: May 2023

Laktik asit bakterileri, endüstride starter kültür veya probiyotik olarak kullanılmaktadırlar. European Food
Safety Authority (EFSA) tarafından 2021 yılında yayımlanan raporda gıdalarda kullanılacak bakterilerin
tüm genom dizileri üzerinden risk değerlendirmesi yapılması gerekliliği vurgulanmıştır. Bu nedenle,
laktik asit bakterilerinde dirençlilik geni araştırmaları önem kazanmıştır. Çünkü antibiyotik direnç
genlerinin bağırsak sisteminde bulunan patojen bakterilere aktarılma olasılığı vardır ya da laktik asit
bakterilerini barındıran gıdalar aracılığıyla alınmaları olasıdır. Bu nedenle, çalışmada, farklı fermente
gıdalardan izole edilen dört laktik asit bakterisi (Lentilactobacillus buchneri Egmn17, Levilactobacillus
brevis Atlas17, Levilactobacillus namurensis Ozge01, Lactiplantibacillus plantarum Gmze16) ve
probiyotik bir bakteri olan Lactiplantibacillus plantarum 299v suşu kullanılmıştır. Çalışmada, laktik asit
bakterileri arasında en yaygın antibiyotik dirençliliği gözlenen tetrasiklin seçilmiştir. 3 bakterinin
tetrasiklin antibiyotiğine orta derecede dirençli (zon çapı 15-18 mm) (299v, Gmze16 ve Egmn17) ve 2
bakterinin duyarlı (zon çapı >19 mm) (Atlas17 ve Ozge01) olduğu belirlenmiştir. Laktik asit
bakterilerinin tüm genom sekanslarının incelenmesi sonucu, orta dirençli bakterilerin tetrasikline bağlı
antimikrobiyal direnç (AMR) genlerinden tetA (MFS dışa atım pompası) ve tetO’ya (ribozomal koruma
proteini) sahip oldukları görülmüştür. Levilactobacillus brevis Atlas17’de ise TetA proteini mevcutken
322. aminoasit sekansında M → T değişimi gözlenmiştir. Ayrıca probiyotik bakteri olan
Lactiplantibacillus plantarum 299v’nin direnç genlerine sahip olması bu genlerin bağırsaktaki patojenlere
aktarılma riskini de arttırmaktadır. tetA genine sahip olduğu gözlenen Levilactobacillus brevis Atlas17
gibi fenotipi duyarlı olan türler de sessiz dirençlilik genlerine sahip olduklarında bunu diğer bakterilere
aktarabilmeleri olasıdır. Bu nedenle genotip ve fenotip birlikte incelenmesi önemlidir
Inhibitor Effects of Some Artificial Tears Drops on Human Carbonic Anhydrase Enzyme-II (hCA-II)
Authors: ÇALIŞKAN Büşra , AKSOY Mine
Published: May 2023

Carbonic anhydrases (CAs) are a metalloenzyme that contains zinc ions in their active sites, and they reversibly catalyze the reactions of hydration of CO2 and dehydration of HCO3-in the living. In this study, human carbonic anhydrase II (hCAII) isoenzyme was purified from human erythrocytes by affinity column (Sepharose 4B-L-tyrosine-sulfanilamide). The inhibitory effect of artificial tear drops on hCAII isoenzyme was investigated. IC50 values were calculated as 1.01 µL for sodium hyaluronate, 140.06 µL for polyvinyl alcohol+povidone, and 49.51 for polyethylene glycol+propylene glycol. The Ki value for sodium hyaluronate was found as 0.339±0.121 mM. According to these results, sodium hyaluronate was the most effective inhibitor in terms of application volume (microliter) among the three drugs examined.
The study is an attempt to reveal and describe the main directions of digital transformation of business models of professional sports organizations through the example of the US National Football League. Based on the Johnson, Christensen and Kagermann’s approach to describe four main components of a successful business model, the authors analyzed the National Football League business model and studied digital technologies impact on the business model components. With reference to the results of analysis as well as the available materials published in foreign mass media, the authors defined the main directions of digital transformation for business models of professional sports organizations. The first direction of transformation is to change the customer value proposition by means of fan engagement into value added chain. The second direction relates to the creation of new revenue channels through business model transformation into D2C type. The results of the current study contribute to the existing research on of business models of sports organizations and can be applied by sports managers in building a digital marketing strategy and a strategy for business model transformation
Authors:   St. Petersburg State University, Klishevich Daria S.
Published: May 2023

This study examines the relationship between state ownership and internationalization in Russian companies. International expansion of state firms from emerging markets is the topic frequently addressed in the research community of international business and strategic management, whereby the studies on emerging markets state-owned enterprises internationalization provide contradictory results. One of the reasons is the difference between the contexts of countries where state-owned enterprises operate which affects the way how state ownership is related to internationalization. Russian state-owned enterprises are the least studied companies in terms of their international expansion, and the examination of the relationship between state ownership and internationalization of firms can fill in the gap in the emerging market state-owned enterprises internationalization puzzle. The paper shows the study of the internationalization of the Russian state-owned enterprises spanning a five-year period 2013–2017. The results show that the more the degree of state ownership in a Russian company is, the less its internationalization is. The study contributes to the discussion of the role of state ownership for the internationalization of emerging market firms by emphasizing the importantce of the contextual country specifics. The study also discusses the role of a state in the internationalization of companies.
Assessment of WASH infrastructure in schools in Central Sulawesi, Indonesia using structured observations and principal interviews
Authors: Ahmed Imaduddin , Garfias Royo Margarita , Opabola Eyitayo , Nurdin Sukiman , Meilianda Ella , Idris Yunita , Rusydy Ibnu , Joffe Helene , Parikh Priti
Published: May 2023

Adequate water, sanitation, and hygiene (WASH) facilities in schools are vital, especially for girls. This study addresses a gap in assessing the adequacy of WASH facilities' repair at schools affected by natural hazards. Central Sulawesi was used as a case study where principal interviews were conducted at 26 schools, and structured observations were made at 18 schools, 3 years after the earthquake in September 2018. Ten of 26 principals reported no damage to the toilets from the events of September 2018. Among those who did, a third felt that the fixes insufficiently met basic needs and that they did not deliver WASH services as well as they used to. Not all WASH inadequacy stemmed from the earthquake. Structured observations revealed that most toilets lacked soap, open water reserves were placed next to non-flush latrines, posing a high potential for vector-breeding, and there were inadequate facilities for menstrual hygiene management, including no bins. Recommendations include ensuring a supply of soap, adding lids to water storage containers, and providing sanitary napkins and lidded bins. Observations suggested that private schools provided a better level of WASH service than state schools, and schools in more hazardous zones did not take longer to recover.
UPGRADING METHODOLOGY AND HARD- AND SOFTWARE FOR OBTAINING TELEMEDICINE VIDEO INFORMATION IN SPACE FLIGHTS
Authors:   Institute of Biomedical Problems of Russian Academy of Sciences, Moscow, Orlov O.I. , Popova I.I. ,   Institute of Biomedical Problems of Russian Academy of Sciences, Moscow, Reviakin Yu.G. ,   Keldysh Institute of Applied Mathematics of Russian Academy of Sciences, Moscow
Published: May 2023

The paper describes the telemedicine methods of video info acquisition from cosmonauts in the ISS RS using the available hard- and software for ENT, periodentium and teeth imaging and full examination in the course of mission, after extravehicular activities or dynamic flight stages, as well as in the pre-launch and post-landing periods within the program of space experiment LOR. Also, the paper presents the results of computerized examination and tele-imaging of the upper airways tunica mucosa, pariodentium, tooth crown, auricle and middle ear.
THE IMPACT OF ARTIFICIAL GRAVITY MODELLED IN SHORT-ARM CENTRIFUGE ON THE EXPRESSION OF TLR-ASSOCIATED GENES OF INNATE IMMUNITY
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, Vlasova D.D. , Sadova A.A. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, Germanov N.S. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Galina V.S. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Shmarov V.A. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, Kutko O.V. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, Rykova M.P. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, Antropova E.N. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, Koloteva M.I. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, Lysenko E.A. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, Orlova K.D. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, Ponomarev S.A. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
Published: May 2023

Here, we report the changes in the expression of TLR-associated genes, genes of NF-kB, AP-1, and TLR4 pathways, genes coding for apoptotic proteins, cytokines, and chemokines, after rotation on the short-arm centrifuge. The study involved 10 almost healthy male volunteers aged 25-40. CD14+ monocytes were isolated from the testers’ blood before and after the exposure to the artificial gravity. The cells were incubated with TLR1-9 ligands for 24 hours to assess the monocytes’ reserve potential. The gene expression was evaluated by real-time PCR. In sum, no negative effect of rotation on the short-arm centrifuge on the functioning of TLR-associated branch of innate immunity was detected.