bluuebunny/crossref_metadata_2025 huggingface dataset:
AN ANALYSIS OF THE APPROPRIATE MANAGEMENT SYSTEM FOR FUEL ENTERPRISES
Authors: MANIKHONG Bouasaveng
Published: December 2018

This case study is aimed to study 1) Environmental factors that affect the analysis and management planning. 2) Competitiveness in business environment. 3) Potential strengths and weaknesses in expanding business. 4) Partner needs. 5) Infrastructure which directly affects business analytics and planning in accordance with the main factors and 6) Lao people's knowledge and skills that influence the management system of the organization by using quantitative study. The quantitative study is in the form of modalities, in which the questionnaires are used as a tool to analyze the samples of 16 fuel companies in Lao PDR (From 27 companies, there are 2 companies that will be closed due to business practice that were inconsistent with the Lao law as well as in 2016, there are 8 new companies which are licensed by the government but the business is still not formal and steady, and yet, 16 companies were still continued to operate their business for a while in Lao PDR). The relationship format consists of 6 independent variables and 4 dependent variables which analyzes data with a statistical endpoint for the integration of variables. The result shows that Structural Equation Model has a relationship with independent variables that influences business planning and setting up management system in accordance with business’s target needs and employees can use as a guideline to follow their work instructions as well as understand their work performance in order to carry out its work and well-planned to achieve the company business goals as well as the benefits they will get in the future.
Laringinė palpacija skydliaukės chirurgijoje: praktinės rekomendacijos, remiantis išsamia literatūros apžvalga ir perspektyviojo kohortinio tyrimo rezultatais
Authors: Rybakovas Andrius , Matulevičius Andrius , Belogorceva Viktorija , Beiša Virgilijus , Strupas Kęstutis
Published: December 2018

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]

Skydliaukės operacijų pasaulyje daugėja. Grįžtamojo gerklų nervo pažeidimas yra viena rimčiausių su skydliaukės chirurgija susijusių komplikacijų. Abipusis nervo pažeidimas lemia blogesnę gyvenimo kokybę, balso ir kvėpavimo funkcijų sutrikimus. Siekiant sumažinti minėtos komplikacijos dažnį, kuriama ir taikoma įvairių naujų intraoperacinės technikos metodų.

Vienas iš šiuolaikinių metodų, leidžiančių veiksmingai išvengti abipusio nervo pažeidimo, yra intraoperacinis neuromonitoringas. Šis metodas intraoperaciniu periodu patikimai įvertina funkcinę nervo būklę, tačiau yra brangus. Laringinė palpacija yra pigi alternatyva, tačiau nėra aišku, ar pastarasis metodas yra pakankamai jautrus ir specifiškas. Todėl šiame straipsnyje, atlikus išsamią mokslinės literatūros analizę ir išanalizavus perspektyvinio kohortinio tyrimo rezultatus, siekiama pateikti laringinės palpacijos metodo vertinimą.

Mokslinėje literatūroje nurodoma, kad laringinės palpacijos metodo jautrumas varijuoja nuo 33 proc. iki 100 proc., specifiškumas – nuo 92 proc. iki 100 proc. Mūsų vykdyto tyrimo VUL Santaros klinikose duomenimis, metodo jautrumas – 100 proc., specifiškumas – 96,6 proc.

Remiantis išsamia literatūros apžvalga ir perspektyviniu kohortiniu tyrimu, galima pateikti rekomendacijų, kaip laringinės palpacijos metodą taikyti modernioje skydliaukės chirurgijoje: 1. Operuojant skydliaukę, visais atvejais būtina identifikuoti grįžtamąjį gerklų nervą. 2. Intraoperacinę neurostimuliaciją tikslinga atlikti visų tiroidektomijų metu. Negalint atlikti intraoperacinio neuromonitoringo, gerklų palpacinė neurostimuliacija galėtų būti pirmojo pasirinkimo metodas. 3. Pašalinus pirmąją skydliaukės skiltį, siekiant išvengti nervo abipusio pažeidimo, operaciją tikslinga tęsti tik patvirtinus šio nervo funkcinį vientisumą, naudojant intraoperacinę neurostimuliaciją.
Kegalauan Identitas dan Kekerasan Sosial: Multikulturalisme, Demokrasi dan Pancasila
Authors: Azra Azyumardi
Published: December 2018

Turmoil identity became one of the most obvious symptoms of Indonesian community in the Post-Soeharto Era. The roots of the turmoil of identity is not only related to changes in political, social, economic, cultural and religious locally internally, but also with the expansion and penetration of the change and globalization. The emergence of social violence, loss of patience, social temper, the decline of respect and obedience to the law, ethics and morals, as well as the nuances of ethnic and religious conﬂ ict showed persistent social crisis that followed the disorientation of cultural identity. Keywords: kegalauan identitas, krisis identitas, kekerasan sosial, multikulturalisme, demokrasi, rejuvenasi Pancasila, bhinneka tunggal ika.
Welfare Approach untuk Indonesia Damai dan Sejahtera: Perspektif Kesejahteraan Sosial
Authors: Ariefuzzaman Siti Napsiyah
Published: December 2018

Symptoms of social violence that characterized by widespread ﬁ ghting between teens, ﬁ ghting between villages, burning houses, or the bombing which tends to lead to acts of terrorism and radicalism is still rife in our society. Motives and the reasons are many and complex. Among these factors is triggered by religious fanaticism, group, ethnicity, and socioeconomic disparities due to the very closely related to poverty and underdevelopment. This paper describes a welfare approach as a complete strategic framework to end social violence and terrorism in Indonesia. Keywords: kekerasan sosial, radikalisme, jihad, terorisme, security approach, welfare approach.
Media Baru dan Potensi Terorisme Virtual
Authors: Nasrullah Rulli
Published: December 2018

It is interesting to look at the Head of Criminal Investigation statement of the Indonesian National Police Commissioner General Ito Sumardi (Kompas, 22/9/2010), which warns that the crime of terrorism is closely related to ideology. Sociologist Van Dijk (1993) states that ideology is basically a mental system that is exchanged, represented both in the level of discourse and action to achieve certain goals or desires in a groups (deﬁ ned as the system of mental representations and processes of group members). Why (technology) Internet so powerful in spreading the message of terrorism? First, the interaction happens on internet can be done anywhere and anytime. Second, Internet users in Indonesia, which is increasingly growing in number, allows access to the site or content to be easily obtained terrorism. Third, Internet medium provides access not only cheap but free. Fourth, the Internet allows anyone to construct new identity. In a fact proves that the identities of individuals in cyber world are individuals who have two possibilities, it could be the same or different identities as in the real world. Furthermore, the individual does not only have one identity per se on the internet, they could have multiple identities as well as different characteristics from each other. In according to Gilmore (1996), those on the Internet nobody knows you at all, not either knows your race or your sex. This is the opportunities that could be used by the perpetrators of terrorism to spread the ideology of terrorism and violence in the name of religion without worried their identity will be revealed. Key words: cybermedia, virtual terorism, internet, identity.
Strategi Fundraising Di Badan Amil Zakat Daerah (Bazda) Kota Bekasi
Authors: Humaini Ayatulloh
Published: December 2018

One of the major success factors of a Zakah Management Organization (Organisasi Pengelola Zakat/OPZ)—whether it is BAZIS or LAZIS—is its sincerity in carrying out fundraising. If OPZ is active, both in planning and fundraising strategy, the existence of OPZ will last long. Local Zakat Agency (Badan Amil Zakat Daerah/BAZDA) Bekasi is a one of OPZ that has been in progress and development, particularly in fundraising results. This success is inseparable from fundraising strategy that has been implemented by BAZDA Bekasi. The results of this research illustrated that in 2012 BAZDA Bekasi had arranged two strategies: First of all the core strategy, consisted of: zakat collection unit, special Ramadan events, charity boxes, and media campaign. Secondly, a specific strategy, included convenience donation, post-donation services, and programs of action.Keywords: strategi fundraising, BAZDA, strategi inti, dan strategi khusus.
Pemberdayaan Masyarakat Miskin di Bantaran Kali Ciliwung
Authors: Manurung Dormiana Yustina
Published: December 2018

Masyarakat miskin yang tinggal di bantaran Kali Ciliwung sudah lama mengalami beragam persoalan sosial, dari serangan banjir, keterbatasan kesempatan kerja, hingga ancaman penggusuran. Namun, melalui pendampingan Yayasan Ciliwung Merdeka (YCM),  masyarakat bantaran Kali Ciliwung mampu bertahan dalam memenuhi kebutuhan hidup sehari-hari, membangun sistem komunal, mengembangkan usaha informal, serta menciptakan pola hidup yang dinamis. Karenanya, YCM memiliki peran penting dalam pemberdayaan masyarakat melalui penyelenggaraan program-program sosial dalam dimensi luas, yang meliputi kegiatan kesehatan, pendidikan, pemberdayaan ekonomi, kesenian dan kebudayaan, serta aksi peduli lingkungan. Dengan modal dan jaringan sosial yang dimiliki YCM, masyarakat di bantaran Kali Ciliwung mampu menjadi mandiri dan produktif. Tulisan ini akan mengkaji dinamika dan relasi sosial masyarakat miskin yang tinggal di bantaran Kali Ciliwung.Keywords: social capital, trust, networking, community development, civil society.
Pengurangan Risiko Bencana: Sebuah Restrospeksi Pasca-Tsunami Aceh 2004
Authors: Rafliana Irina
Published: December 2018

Isu kebencanaan masih belum banyak dikaji dalam disiplin ilmu sosial; seolah persoalan kebencaan dipandang sebatas fenomena alam dan tidak berkaitan dengan dinamika sosial; seolah korban kebencanaan hanya perlu dipulihkan kembali sementara proses pemulihan dan konsekuensinya luput dicermati. Peristiwa Tsunami Aceh pada tahun 2004, dengan besarnya jumlah korban dan kehancuran yang diakibatkannya, mendorong para pengkaji sosial untuk semakin memerhatikan persoalan kebencanaan lebih serius. Tulisan ini akan mengkaji proses intervensi berbagai kalangan terhadap korban bencana. Diskursus kebencanaan memang dimulai dari disiplin ilmu alam yang memunculkan pendekatan teknikalisasi intervensi. Namun, ilmu sosial dapat berperan menambah cara pandang dan menguatkan pemahaman tentang berbagai risiko dan konsekuensi sosial, yang luput dari perhatian pendekatan-pendekatan teknikalisasi.Keywords: pengurangan risiko bencana, intervensi sosial, Tsunami Aceh.
Mu’allaf: Perspektif Pekerjaan Sosial
Authors: - Noorkamilah
Published: December 2018

Convert to Islam (Mu’alaf) is a term used in the Qur’an to refer to a group of people who ‘softened his heart’, can also be viewed from the perspective of the social sciences, particularly the disciplines of social work. Many disadvantaged mu’alaf phenomenon turned out to be conceptually included in the category of minorities in the social work perspective. They require attention like the social welfare services (PPKS) to another. In other words mu’alaf, including PPKS category that had been forgotten. Not coincidentally, it turned out in the language of religion mu’alaf also included in the category mustahik, a group of people who are eligible to receive zakat, meaning that groups of people who need special attention. This paper attempts to integrate and interconnect purport about mu’alaf from two perspectives: social work and an Islamic perspective.Keywords: Mu’allaf, mal-adaftif, intervensi sosial dan Peran Pekerja Sosial
Model Penanggulangan Kemiskinan Berbasis Aset Masyarakat di Kecamatan Jatinangor
Authors: Resnawaty Risna , Fedryansyah Muhammad
Published: December 2018

The pattern of top-down development often create new problems for society, among others, issues of poverty that occurred in the area of   education Jatinangor. The local community were marginalized by the regional changes. Agriculture areas which is the place for working has transformed into educational and residential areas. The change didn’t considering the ability of society to change in accordance with the expected development. Various programs of addressing poverty has been done by the government but the level of unemployment and poverty in the region Jatinangor not significantly reduced. The low level of education of the community in reality that is ironic for an area  which has five colleges of higher education. To overcome these problems, Community development is one strategy for urban poverty reduction, Jatinangor has community-owned assets as capital that can be used to reduce the problems of poverty. There are two important issues relating to existing assets include “optimalization” strategy purposes to improve the functioning of the asset in improving the quality of life and solving problemsof poverty, as well as the “revitalization” strategy purposes to improve existing assets or deemed less support or be the ause of the problem of poverty itself.Keywords: Community Development, Assets Based Community Development, Poverty Reduction.
Penggunaan Token Economies pada Anak untuk Meningkatkan Kedisiplinan dalam Menaati Peraturan
Authors: Mardina Mutiara , Santoso Meilanny Budiarti
Published: December 2018

The use of economies token for 12 years children aims at improving the discipline in complying with the rules at an orphanage institution. In the handled cases, the client has a problem against disciplinary, particularly related to the rules of the institutions, with the result that the client was often scolded. This article argues on the important of this token to uphold discipline guidance and mentoring. In this practice, the theory used is a behavioral therapy with the technique of economy token. The use of therapy behavioral methods intended to improve or maintain adaptive behavior, reduce or eliminate the maladaptive behavior, and reduce or eliminate the excessive behavior. By using economy token method, it is expected to help the client to have guidelines for improving discipline in complying with the rules. Based on 4 months of field assistance approach, the results of the assistance for 12 years old children who needs assistance in disciplinary training with economy token, communication and good thinking have become an important factor in relation to the development of a person, so that clients can reduce negative thoughts and changing dysfunctional thinking process.Keywords: discipline, behavioral therapy, economy token, 12 years old children.
Interkalasi Ion Mefenamat pada Host Mg/Al Hidrotalsit sebagai Rancangan Obat Lepas Lambat
Authors: Sari Fajar Indah Puspita
Published: December 2018

The aim of this study was to intercalate mefenamic ions in the interlayer structure of Mg/Al hydrotalcite and to test the release of mefenamic ion from host hydrotalcite interlays to determine its potential as a slow release drug design. Intercalation of mefenamic ions into interlayer structure of Mg/Al hydrotalcite by ion exchange has been studied. This success intercalation was confirmed by XRD data, diffractogram before and after intercalation showed a shift of d003, d006 and d009. The change of d003 from 8.717 Å to 22.017 Å indicates that the mefenamic ion has entered the interlayers of hydrotalcite. The FTIR analysis confirms that the nitrate ion was successfully replaced by mefenamic ions in the hydrotalcite interlayer. FTIR data indicate the absorption of symmetry and asymmetry of carboxylic groups in 1381 and 1612 cm-1 of the mefenamic ion. Have studied ion exchange kinetics and release of mefenamic ions from hydrotalcite hosts to determine their potential as a slow-release drug design. The result show mefenamic ion can be released from the hydrotalcite host for 6 hours. So that Mg / Al hydrotalcite has the potential to be used in slow release drug design.
Physical Activity and Sedentary Behavior From 6 to 11 Years
Authors: Schwarzfischer Phillipp , Gruszfeld Dariusz , Stolarczyk Anna , Ferre Natalia , Escribano Joaquin , Rousseaux Déborah , Moretti Melissa , Mariani Benedetta , Verduci Elvira , Koletzko Berthold , Grote Veit
Published: December 2018

OBJECTIVES:

Physical activity (PA) is presumed to decline during childhood and adolescence, but only few long-term studies about PA development during this period of life exist. We assessed PA and sedentary behavior (SB) over a 5-year period to gain a better understanding of the extent of change in activity and potential influencing factors.

METHODS:

PA and SB of 600 children from the Childhood Obesity Project were objectively measured with the SenseWear Armband 2 at the ages of 6, 8, and 11 years, resulting in 1254 observations. Longitudinal changes of total PA, moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), and SB were modeled with mixed-effects models.

RESULTS:

Total PA revealed a significant quadratic decline with age (P < .001), resulting in a change of total PA by −75.3 minutes per day from 6 to 11 years. LPA linearly declined (P < .001) by 44.6 minutes per day, MVPA quadratically declined (P < .001) by an overall 30.7 minutes, whereas SB increased significantly (+107 minutes; P = .001). Boys showed a steeper decline in LPA (P = .003) and MVPA (P < .001) than did girls. Higher fat mass index and BMI z scores were associated with lower levels of total PA and MVPA and higher levels of SB (all P < .001).

CONCLUSIONS:

We showed that PA decreased, and SB increased in earlier years than previously thought. MVPA remained relatively stable until 8 years, but revealed a drop-off at 11 years, identifying this period as a crucial time for intervention.
Desacuerdos Básicos entre Pares Epistémicos
Authors: Lo Guercio Nicolás
Published: December 2018

En primer lugar, se presenta el fenómeno de los desacuerdos básicos entre pares epistémicos (esto es, desacuerdos acerca de la naturaleza de la evidencia o el método apropiado para evaluarla) y se argumenta que son relevantes y merecen atención. En segundo lugar, se discute el argumento estándar a favor del conciliacionismo. Finalmente, se defiende que las razones típicas para conciliar no se aplican en los desacuerdos básicos entre pares, de manera que en estos casos está permitido ser obstinado.
La fenomenología merleau-pontiana de la percepción frente a la estética y la analítica trascendentales
Authors: García Esteban A.
Published: December 2018

Se examinan de modo sistemático las críticas de Merleau-Ponty, en la Phénoménologie de la perception, a la teoría kantiana de la experiencia, atendiendo al papel de los conceptos en la conformación de la experiencia objetiva, la relación entre la sensibilidad y el entendimiento, así como la redefinición del carácter formal de la sensibilidad. Se discuten posibles objeciones a la interpretación merleau-pontiana de la teoría kantiana y se evalúa, así mismo, el alcance relativo de ciertas referencias positivas de Merleau-Ponty a nociones kantianas tales como afinidad, sinopsis e imaginación.
“La verdad pasa a ser algo privado”. Algunas consecuencias políticas del silenciamiento del malestar laboral
Authors: Sánchez Madrid Nuria
Published: December 2018

Este trabajo reivindica el interés teórico de los relatos de empleados en el sector servicios, donde exponen el sufrimiento y malestar que conllevan las condiciones laborales a las que están sometidos. En conexión con este fenómeno, se somete a crítica un modelo de Estado que permanece indiferente al sufrimiento de los cuerpos laborantes, al identificar lo que acontece en el ámbito profesional como un asunto privado, en una línea próxima a la distinción entre lo público y lo privado de Hannah Arendt. Así mismo, se presenta la necesidad de cuestionar el neoliberalismo, desde la confianza en la validez de las instituciones republicanas, con vistas a objetivar eldolor y el sufrimiento en el ámbito laboral, que no deberían ser considerados como meros sentimientos subjetivos. Este cuestionamiento se asume como una tarea necesariapara fomentar nuevos modelos sostenibles de subjetividad.
Conversación con Emmanuel Levinas. 20 de Julio de 1992 en Paris
Authors: Stockebrand Gómez Rafael
Published: December 2018

La presente traducción fue realizada del original “Gespräch mit Emmanuel Levinas am 20. Juli 1992 in Paris”, publicado en Emmanuel Levinas- eine Herausforderung für die christliche Theologie por Schöningh en 1999, páginas 231-237. Agradezco al profesor Josef Wohlmuth, editor de la obra, por la autorización para publicar esta traducción. Asimismo agradezco a Sara Bertschik por sus agudos comentarios. Esta traducción fue realizada en el marco del proyecto Fondecyt n. 1160479 id 150811071.
Work-Up for Cardiac Involvement in M.3243A>G Carriers Requires Comprehensive and Long-Term Work-Up
Authors: MD, PhD Josef Finsterer, , Scorza, MD Fulvio A. , Scorza Carla A.
Published: December 2018

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Modelo sistemático para utilização dos recursos e ferramentas da plataforma Moodle: uma proposta para mediação da aprendizagem no ensino superior
Authors: Pereira Natana Lopes , Spanhol Fernando José , Lunardi Giovani Mendonça
Published: December 2018

Devido à necessidade da utilização eficiente e eficaz dos recursos tecnológicos disponibilizados nos Ambientes Virtuais de Ensino e Aprendizagem – AVEA, o artigo apresenta um roteiro para construção e conversão de conhecimento em tais plataformas educacionais. Assim, a pesquisa objetiva a partir de um modelo inicial, proporcionar maior efetividade nos AVEA por meio da aplicação dos quatro modos de conversão do conhecimento. Para delimitação da pesquisa realizou-se estudo bibliográfico sobre os modos de conversão do conhecimento e a plataforma educacional Moodle. A partir da elaboração e estruturação do roteiro para conversão do conhecimento, evidenciou-se a relevância da combinação dos recursos de forma sistemática para o processo de ensino e aprendizagem mediados por tais ferramentas.
Child with autistic spectrum disorder: care from the family
Authors: Mapelli Lina Domenica , Barbieri Mayara Caroline , Castro Gabriela Van Der Zwaan Broekman , Bonelli Maria Aparecida , Wernet Monika , Dupas Giselle
Published: December 2018

Abstract Objective: To know the experience of the family in the care of the child with Autism Spectrum Disorder (ASD) and to discuss possibilities of health care. Method: Descriptive research with qualitative approach, carried out with 15 families of children with ASD, living in two municipalities in the interior of the state of São Paulo, from October 2016 to March 2017. The Symbolic Interactionism was used as theoretical reference, and Narrative Analysis, as method. Results: Families perceive signs of autism, however, believe that there are not suspicious behaviors, but the child's personalities. When diagnosis is defined, family acceptance is painful and sad. The mother shows to be the main caretaker, while the father remains in the background. A significant change of direction of the family towards the care/attention/stimulation of the autistic child is observed. Conclusion: Unveiling family experience in the care of children with ASD amplifies strategies for reinforcement and adaptation.
Quality of life after treatment for cervical cancer
Authors: Correia Rafaella Araújo , Bonfim Cristine Vieira do , Ferreira Daniela Karina da Silva , Furtado Betise Mery Alencar Sousa Macau , Costa Heitor Victor Veiga da , Feitosa Kéllida Moreira Alves , Santos Solange Laurentino dos
Published: December 2018

Abstract Objective: Identify the quality of life of women treated for cervical cancer according to their clinical and socioeconomic characteristics. Methods: This was a analytical study on women who were treated for cervical cancer by means of surgery, radiotherapy and chemotherapy. To evaluate their quality of life, the WHOQOL-bref questionnaire was applied. The Mann-Whitney test was used to investigate associations between domains and variables. Results: There were associations (p < 0.05) between the WHOQOL-bref domains and the variables of income, conjugal situation, leisure activities and treatment undergone. The physical and psychological domains were associated with overall quality of life (R = 0.54 and R = 0.63, respectively). Conclusions: Socioeconomic conditions and the type of treatment undergone influenced the quality of life of these women after their treatment. There is a need to increase the reach of cervical cancer screening among women who are less economically favored; and, after treatment, to offer alternative measures that soften the secondary effects.
The family strengths in the context of psychoactive substance dependence
Authors: Claus Maria Izabel Sartori , Zerbetto Sonia Regina , Gonçalves Angélica Martins de Souza , Galon Tanyse , Andrade Letícia Grazielly Zanon de , Oliveira Fernando Calzavara de
Published: December 2018

Abstract Objective: To apprehend the perception of relatives of psychoactive substances dependents about their facilitating strengths to deal positively with the adversities from this context. Method: Qualitative and descriptive study developed between July/2016 and August/2017 at Psychosocial Care Center Alcohol and Drugs of a city on the countryside of São Paulo, through a semi-structured interview for data collection. Eight family members of chemical addicted participate. The interviews were recorded by audio, transcribed and analyzed by content analyze technique, thematic category. Results: The relatives recognized that their facilitating strengths permeated through the religiosity and spirituality, beliefs systems, support from the specialized mental health service support and of friendship, whilst social support network. The strengths also depended on the cohesion and assertive communication of the family. Conclusion: The facilitating strengths recognized by relatives help them deal positively with adversities in the chemical addiction context, strengthening the familiar resilience.
Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis
Authors: Wu Haojia , Kirita Yuhei , Donnelly Erinn L. , Humphreys Benjamin D.
Published: December 2018

Background

A challenge for single-cell genomic studies in kidney and other solid tissues is generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate cell types and is free of both RNA degradation and artifactual transcriptional stress responses.

Methods

We compared single-cell RNA sequencing (scRNA-seq) using the DropSeq platform with single-nucleus RNA sequencing (snRNA-seq) using sNuc-DropSeq, DroNc-seq, and 10X Chromium platforms on adult mouse kidney. We validated snRNA-seq on fibrotic kidney from mice 14 days after unilateral ureteral obstruction (UUO) surgery.

Results

A total of 11,391 transcriptomes were generated in the comparison phase. We identified ten clusters in the scRNA-seq dataset, but glomerular cell types were absent, and one cluster consisted primarily of artifactual dissociation–induced stress response genes. By contrast, snRNA-seq from all three platforms captured a diversity of kidney cell types that were not represented in the scRNA-seq dataset, including glomerular podocytes, mesangial cells, and endothelial cells. No stress response genes were detected. Our snRNA-seq protocol yielded 20-fold more podocytes compared with published scRNA-seq datasets (2.4% versus 0.12%, respectively). Unexpectedly, single-cell and single-nucleus platforms had equivalent gene detection sensitivity. For validation, analysis of frozen day 14 UUO kidney revealed rare juxtaglomerular cells, novel activated proximal tubule and fibroblast cell states, and previously unidentified tubulointerstitial signaling pathways.

Conclusions

snRNA-seq achieves comparable gene detection to scRNA-seq in adult kidney, and it also has substantial advantages, including reduced dissociation bias, compatibility with frozen samples, elimination of dissociation-induced transcriptional stress responses, and successful performance on inflamed fibrotic kidney.
Supervisory Stress Testing For CCPs: A Macro-Prudential, Two-Tier Approach
Authors: Anderson Edward , Cerezetti Fernando , Manning Mark
Published: December 2018

Stress testing has become an increasingly important mechanism to support a variety of financial stability objectives. Stress tests can be used to test the individual resilience of a single entity or to assess the system-wide vulnerabilities of a network. This article examines the role of supervisory stress testing of central counterparties (CCPs), which has emerged in recent years. A key message is that crucial differences in CCPs’ role, risk profile and financial structure, when compared to banks, are likely to require significant adaptation in the design of supervisory stress tests (SSTs). We examine how supervisory stress tests may be designed to complement CCPs' own daily stress tests, and argue that macro-prudential supervisory stress testing of CCPs is valuable for both authorities and market participants. The paper offers practical guidance on the implementation of the exercises and proposes some specific design principles that should allow authorities to extract more information from such tests. We propose a two-tier approach that meets the intended policy objectives, while balancing ambition and resource cost. The first tier encompasses more standardized tests that can be conducted frequently to assess the resilience of the clearing network over time. The second tier encompasses less frequent and more complex 'deep dive' assessments. The proposed approach should overcome operational and resource challenges, which to date, may have inhibited the widespread application of supervisory stress testing.
A Promised Value Approach to Optimal Monetary Policy
Authors: Hills Timothy S. , Nakata Taisuke , Sunakawa Takeki
Published: December 2018

This paper characterizes optimal commitment policy in the New Keynesian model using a novel recursive formulation of the central bank's infinite horizon optimization problem. In our recursive formulation motivated by Kydland and Prescott (1980), promised inflation and output gap---as opposed to lagged Lagrange multipliers---act as pseudo-state variables. Using three well known variants of the model---one featuring inflation bias, one featuring stabilization bias, and one featuring a lower bound constraint on nominal interest rates---we show that the proposed formulation sheds new light on the nature of the intertemporal trade-off facing the central bank.
Cross-Border Bank Flows and Monetary Policy
Authors: Correa Ricardo , Paligorova Teodora , Sapriza Horacio , Zlate Andrei
Published: December 2018

We analyze the impact of monetary policy on bilateral cross-border bank flows using the BIS Locational Banking Statistics between 1995 and 2014. We find that monetary policy in the source countries is an important determinant of cross-border bank flows. In addition, we find evidence in favor of a cross-border bank portfolio channel. As relatively tighter monetary conditions in source countries erode the net worth and collateral values of domestic borrowers, banks reallocate their claims toward safer foreign counterparties. The cross-border reallocation of credit is more pronounced for banks in source countries with weaker financial sectors, which are likely to be more risk averse. Lastly, the reallocation is directed toward borrowers in safer countries, such as advanced economies or economies with an investment grade sovereign rating. By highlighting the effect of domestic monetary policy on foreign credit, this study enhances our understanding of the monetary policy transmission mechanism through global banks.
An Empirical Study on the Relationship between the Cash Conversion Cycle and the Stock Price of Firms in the Food Service Indust
Authors:   The Tourism Sciences Society Of Korea, Shin Yong-Jae , Hong Mi-Young
Published: December 2018

This study examines the relationship between the cash conversion cycle and the stock price of food service industry firms. The sample is firm-year data belonging to 38 firms in the food service industry listed on the Korean exchange from 2010 to 2017. Considering that the sample had properties of the panel data, a panel regression model was employed for the analysis. The main results of the study are as follows. First, there was a significant negative (-) relationship between the stock price and the cash conversion cycle of food service industry firms. This means that the shorter the cash conversion cycle, the higher the value of the shares. Based on this result, it can be inferred that reducing the investments of working capital would be an efficient working capital management policy for sample firms. Second, in the analysis of the effect of financial constraints on the relationship between the cash conversion cycle and the stock price, it was confirmed that the effect was not significant. This result implies that financial constraints are not considered to be a factor that would change the working capital management policy of food service firms. This study is meaningful in that it is the first study to investigate the impact of the cash conversion cycle and the firm value for firms in the food service industry listed on the Korean exchange.
La Ley de Seguridad Interior en México: entre la razón de Estado y la justificación de los derechos humanos/ The Law of Internal Security in Mexico: between the reason of State and the justification of human rights
Authors: Medellín Mendoza Laura Nelly
Published: December 2018

Presentamos un análisis cualitativo exploratorio-descriptivo desde la Ciencia Política acerca de la argumentación sostenida en las iniciativas de la Ley de Seguridad Interior (LSI) presentadas por el Partido Revolucionario Institucional (PRI), el Partido Acción Nacional (PAN) y el Partido de la Revolución Democrática (PRD). Dos conceptos operativos guían el análisis: razón de Estado y derechos humanos, presentes tanto en las justificaciones implícitas de quienes impulsan la Ley como en las de sus detractores, quienes la califican de violatoria de derechos humanos. En este último punto, nos concentramos en revisar dos acciones de inconstitucionalidad presentadas por la Comisión Nacional de los Derechos Humanos (CNDH) y por un grupo de legisladores de oposición que no votaron a favor de la LSI en la Sexagésima Tercera Legislatura. Nos interesa mostrar la colisión de argumentos entre la visión de Estado, que quiere legitimar jurídicamente la presencia del Ejército en las calles y la otra visión, que asume una justificación garantista de los derechos humanos.

Abstract

We present an exploratory qualitative analysis from the standpoint of Political Science about the argumentation sustained in the initiatives of the Internal Security Law (LSI) presented by the Institutional Revolutionary Party, the National Action Party and the Party of the Democratic Revolution. Two operative concepts guide the analysis: reason of State and human rights, both present in the implicit justifications of those who promote the law, and in those of its detractors, who qualify it as a violation of human rights. In this last point, we concentrate on reviewing two unconstitutionality actions presented by the National Commission of Human Rights and by a group of opposition legislators who did not vote in favor of the LSI in the Sixty-Third Legislature. We aim to show the collision of arguments between the vision of the State, which wants to legally legitimize the presence of the Army in the streets, and the other vision, which assumes a guaranteeing justification of human rights.
Miradas desde el sur de México sobre seguridad y frontera/ Gazes from southern Mexico on security and border
Authors: Ramos Rojas Diego Noel , Coraza de los Santos Enrique , Martínez Junco Santiago
Published: December 2018

La llamada “frontera sur de México” representa un fenómeno multivariable y poliédrico, que encarna una complejidad por su carácter de región transfronteriza, a la vez que conforma uno de los corredores de movilidad humana más importantes del mundo. En este artículo presentamos un estudio sobre esta realidad a partir de dos acercamientos complementarios. En primer lugar, comprende un estudio conceptual, teórico y contextual sobre lo que representa ese espacio en diferentes escalas, desde la regional hasta la global. En segundo lugar, un estudio micro sobre las percepciones de las personas que viven la frontera, a partir de testimonios recogidos en las ciudades situadas en las orillas del río Suchiate (límite entre México y Guatemala).

Abstract

The well-known "southern border of Mexico" represents a multivariable and multifaceted phenomenon that embodies a complexity due to its cross-border region characteristic. It is worldwide identified as one of the most important human corridors. In this article we present a study about this situation from two complementary approaches. In one hand, we performed a conceptual, theoretical and contextual study about what this space represents, in different scales, from regional to global perspective. On the other hand, we present a micro study that approaches the perceptions of people who live at the border region, with testimonies collected in the cities located along the Suchiate riverside (border between Mexico and Guatemala).
Propuestas para regular las migraciones en Chile y la obstinación del securitismo/ Proposals to regulate migrations in Chile and the obstinacy of securitism
Authors: Concha Villanueva Sebastián Andrés
Published: December 2018

El siguiente artículo tiene como objetivo analizar de manera comparativa los proyectos para regular las migraciones en Chile de los Gobiernos de Michelle Bachelet y Sebastián Piñera. Se argumenta que ambos comparten un rasgo común: pese a contener elementos que se basan en la promoción de derechos, mantienen características que se corresponden con una lógica de control. Se resume el fenómeno chileno de la inmigración, que motiva a crear una normativa que reemplace a la vigente; se analiza la actual Ley de Extranjería y se establece un marco comparativo que dirime las particularidades de las propuestas de Ley Migratoria hechas por los Gobiernos de Michelle Bachelet y Sebastián Piñera.

Abstract

This paper aims to analyze, in a comparative perspective, the projects to regulate migrations in Chile presented by the governments of Michelle Bachelet and Sebastian Piñera. It is argued that both share a common feature: despite having elements based on the promotion of rights, they maintain traits that correspond to a control logic. We summarize the Chilean phenomenon of immigration that motivates the creation of a new regulation, analyze the present law and, finally, establish a comparative framework that addresses the particularities of the proposed immigration laws made by the Michelle Bachelet and Sebastian Piñera governments.
Hematoloji kliniğine başvuran hastalarda dermatolojik bulguların değerlendirilmesi: 2 yıllık kesitsel bir çalışma
Authors: AKIN BELLİ Aslı , KARA POLAT Asude , KARAKUŞ Volkan
Published: December 2018

Amaç: Hematolojik
hastalıklardaki deri bulgularının sıklığı ile ilgili ülkemizden bildirilen az
sayıda çalışma bulunmaktadır. Bu çalışma ile hastanemiz Hematoloji
polikliniğinde takip edilen hastalardaki dermatolojik bulguların prevalansını
incelemeyi amaçladık. Gereç ve Yöntem:
Şubat 2014-Haziran 2016 tarihleri arasında hastanemiz Hematoloji polikliniğinde
takip edilen 217 hastayı içeren kesitsel bir çalışma yürütüldü. Hematolojik
hastalık tanıları, hastalık süresi, takip süresi, dermatoloji konsültasyonu
ile elde edilen dermatolojik muayene verileri ve diğer malignite varlığı hasta
dosya kayıtlarından retrospektif olarak incelendi.Bulgular: İki yüz on yedi
hastanın (102 kadın, 115 erkek) yaş ortalaması 63.06±14.7 yıl bulundu. Ortalama
hematolojik hastalık süresi 27.98±35.9 ay ve hastalık takip süresi ise
12.21±6.65 ay olarak saptandı. En sık görülen deri bulguları sırasıyla purpura
(%95 GA, %7.4-%16.1), pruritus (%9.7; %95 GA, %6-%13.8) ve viral enfeksiyonlar
(%5.1; %95 GA, %2.3-%8.3) şeklinde saptandı. Miyelodisplastik sendromlu iki
hastada talidomid ve deferasirox ile ilişkili vaskülitik ilaç reaksiyonu
gözlendi. Spesifik kutanöz infiltrasyonlardan, kutane lösemi kronik lenfositik
lösemili bir hastada; granülositik sarkom ise akut miyeloid lösemili bir hastada
saptandı.

Sonuçlar: Sıklıkla immunsuprese
olan ve çoklu ilaç kullanımına sahip hematoloji hastalarında, deri bulguları
oldukça sık görülmekte olup geniş bir çeşitliliğe sahiptir. Hematolojik
hastalıkların deri bulguları ciddi bir enfeksiyonun, ilaç reaksiyonunun veya
hastalığın deriye yayılımının göstergesi olabileceğinden, bu hastalıkların
teşhis ve tedavisi prognostik öneme sahiptir.
Patial Distribution of Calcium-Overloaded Cardiomyocytes in a Cardiac Muscle: A One-Dimensional Simulation Study
Authors: Nesterova T.M. , Ushenin K.S. , Balakina-Vikulova N.A. , Solovyova O.
Published: December 2018

The premature ventricular contractions are relatively common clinical diagnosis. Ventricular activation initiated from an ectopic focus in the heart ventricles results in
the premature contraction. Pathophysiology of this disease is related to calcium overload in cardiomyocytes when delayed after depolarization aroused due to spontaneous
calcium release from sarcoplasmic reticulum. This could lead to myocardium activation from an ectopic focus and premature ventricular contraction. In our work, we study
calcium overload in cardiomyocytes using one-dimensional monodomain electrophysiological model of the myocardium. Calcium overload in cardiomyocytes is simulated by
inhibition of Na+/K+ exchanger and SERCA-pump within the Noble98 cell model. We propose an algorithm to automatically detect premature activation in the one-dimensional model.
The main goal of our study is to evaluate the effect of a spatial distribution of pathology on the frequency of premature myocardium excitations. Model simulation showed that an
ectopic activation is usually initiated in a region of the maximum pathology. However, if the function of a spatial distribution of pathology had a discontinuity, then an ectopic
activation initiated from the region of discontinuity of a function. Also, we study changes in action potential generation in the pathology region. We obtained a nonlinear and a
nonlocal relationship between spatial distribution of pathology and the degree of sarcoplasmic reticulum overload in the one-dimensional model.
Changes in human sperm motility characteristics in the presence of protein-peptide complex
Authors: Evdokimov V. V. , Efremov E. A. , Elistratov P. A. , Yamskov I. A. , Askerov A. F. , Yamskova V. P. , Turovetsky V. B.
Published: December 2018

The study objectiveis to examine the changes in motility of human spermatozoa under the effect of a protein-peptide complex extracted from cattle testes (Bos taurus).

Materials and methods. The protein-peptide complex was extracted from testes tissue obtained during butchering of cattle at meat processing plants of the Moscow Region. Human spermatozoa were obtained from the ejaculate in the usual way. From the ejaculate sample, 1 ml was collected for the experiment and control. The protein-peptide complex was added to a test tube in concentrations of 10–8, 10–9, and  10–12 mg/ml. For every concentration, 10–12 experiments were performed. General and active motility were evaluated after 30 min, 1 and 3 hours of incubation at room temperature.

Results and conclusion. The experiments have shown that in the presence of the protein-peptide complex, spermatozoa motility increased  by 10–30 % relative to the initial value at 30 minutes, and this change persisted for 3 hours of observation. The change depended on the complex concentration: the largest increase was observed at 10–12 mg/ml. Higher complex concentrations did not have a positive effect  on spermatozoa motility.
Rufinamide (inovelon) in the treatment of Lennox–gastaut syndrome (a review of literature)
Authors: Мukhin К. Yu. , Pylaeva О. A.
Published: December 2018

Lennox–Gastaut syndrome (LGS) is a childhood epileptic encephalopathy characterized by frequent polymorphic seizures (including tonic axial seizures), pronounced cognitive impairment, typical changes in the electroencephalogram and drug resistance. Since the disease is quite common (accounts for 4–10 % of all childhood epilepsy) and is characterized by various seizures that are frequently resistant to multiple antiepileptic drugs, great hopes are currently centered on the development of novel antiepileptic drugs with principally different mechanisms of action aimed to treat this severe form of epilepsy. Rufinamide (inovelon) is a promising antiepileptic drug for LGS therapy. In 2008, it was approved by the FDA as an adjunctive treatment of seizures associated with LGS in adults and children over 4 years of age. Rufinamide demonstrated its efficacy against both drop seizures (tonic/atonic) and generalized seizures (tonic, atonic and tonic-clonic) in LGS. In January 2015, the drug was approved for use in the Russian Federation for seizures associated with LGS in patients over 4 years of age. Multiple studies have demonstrated high efficacy and good tolerability of rufinamide in children and adults with epilepsy. In this article, we provide a systematic review of the currently available data on the use of rufinamide in the treatment of seizures associated with LGS.
Efficacy and tolerability of brivaracetam in the treatment of epilepsy: literature review and own experience
Authors: Pylaeva O. A. , Mukhin K. Yu.
Published: December 2018

Background. Despite significant advances in epileptology, approximately 30 % of patients suffer from drug-resistant epilepsy. Numerous approaches are currently available to treat epilepsy; however, there are still many patients with treatment-resistant disease, in whom surgery is impossible and alternative methods (vagus nerve stimulation and ketogenic diet) are ineffective. Thus, searching for new effective antiepileptic drugs (AED) for these patients remains highly relevant. In this article, we reviewed available publications and provided own results on the efficacy and tolerability of brivaracetam (Briviact®) in patients with intractable focal epilepsy.

Materials and methods. The study included 8 patients aged between 16 and 35 years (mean age 18.3 years; 2 males and 6 females) with intractable focal epilepsy treated at the Svt. Luka’s Institute of Child Neurology and Epilepsy between February 1st, 2017 and September 1st, 2018.

All patients received brivaracetam as an additional AED for the treatment of focal and bilateral convulsive seizures. Patients were followed up for 1 to 7.5 months. Brivaracetam was added to 1 or 2 AED (valproate, topiramate, or carbamazepine/oxcarbazepine) at a dose of 100–200 mg/day divided into 2 doses.

Results and discussion. Good therapeutic effect (more than 50 % reduction in seizure frequency) was registered in 4 patients (50 %). Two patients (25 %) achieved a 25–50 % reduction in seizure frequency. Minimal clinical efficacy with no effect was observed in one patient (12.5 %). One patient (12.5 %) had aggravation of focal and motor seizures. Brivaracetam significantly reduced the severity (intensity and duration) of epileptic seizures in 70 % of patients. Four patients demonstrated substantial improvements on electroencephalogram (decreased epileptiform activity). One patient had complete suppression of epileptiform activity. Brivaracetam was most effective for bilateral convulsive seizures: 4 out of 5 patients experienced complete relief of these seizures.

Brivaracetam demonstrated good tolerability: no side effects were registered in this study. Six out of 8 participants (75 %) currently continue treatment with brivaracetam. It is important that none of the patients had to stop brivaracetam due to poor tolerability. Of note, all of study participants started to receive brivaracetam because they had seizures resistant to multiple (more than 2–3) AED.

Conclusion. Our findings suggest high efficacy and good tolerability of brivaracetam in patients with focal epilepsy. Our results are also consistent with the data reported by foreign authors.