bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovery of Thiopyrimidinone Derivatives as a New Class of Human Aldose Reductase Inhibitors
Authors: Lins Ilária , Maciel Larissa , dos Anjos Janaína
Published: February 2022

Diabetes is a chronic metabolic disorder characterized by insufficient insulin production, the cells’ inability to use this insulin, or a combination of both, leading to secondary complications such as diabetic neuropathy and retinopathy. One way to prevent or control such complications is the use of aldose reductase (AR) inhibitors. In this work, we synthesized and tested new candidates for human AR inhibition containing a 2-thiopyrimidin-4-one heterocycle as a central ring. The fifteen derivatives were tested in vitro and their binding modes were evaluated via molecular docking simulations. AR inhibition assays showed that all synthesized compounds were able to inhibit the AR enzyme at 50 μM. From these results, seven compounds were noteworthy and had their half maximal inhibitory concentration (IC50) values estimated, ranging from 2.0 to 14.5 μM. Molecular docking simulations showed that these compounds bind specifically to the catalytic subpocket and the results indicate a good association between in vitro and in silico studies.
Ideological Influences on Intergroup Attitudes in the Context of The Hague Court Boundary Dispute between Peru and Chile
Authors: Espinosa Agustín , Jiménez-Benítez Victor , Valencia-Moya Juan , Romero Juan Carlos , Sandoval Salvador Antonio
Published: February 2022

In the context of the border dispute presented by Peru against Chile in the The Hague Court, this study analyzes the influences of two ideological motivational dimensions: Right-Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO) on a set of intergroup attitudes that involve both nations. To this end, a survey study of 196 Chileans and 223 Peruvians participants was conducted. The instruments used to measure ideology and political attitudes are the following ones: RWA Scale; SDO Scale; Scale of Intergroup attitudes between Chile-Peru and specific questions on interest in the Hague litigation and willingness to fight for one's country. The results show that in the Peruvian case attitudes of belligerence and alert and a greater willingness to fight for the country are better explained by the RWA, while in the Chilean case these same attitudes are explained both by the RWA as well as the SDO. On the other hand, pacificist attitudes are explained inversely by SDO in both countries. These findings support the hypothesis that intergroup dynamics between both countries have been marked by expressed actions of a Chilean expansionism versus a Peruvian vengefulness and suggest that equalitarianism will promote attitudes toward respect and cooperation between both groups, changing the frames of expansionism and vengefulness for one of a culture of peace.
Cuestionario Revisado de Personalidad de Eysenck (versión reducida): análisis con la teoría de respuesta al ítem
Authors: Abal Facundo Juan Pablo , Ursino Damián Javier , Attorresi Horacio Félix
Published: February 2022

El objetivo de este trabajo es aportar nuevas evidencias de calidad psicométrica para la adaptación argentina de la versión reducida del Cuestionario de Personalidad de Eysenck (EPQ-RS). Participaron 1136 personas de población general (52.5% femenino, edad media = 29.6 años, DE = 11.9) residentes en Buenos Aires, Argentina. La adaptación argentina se compone de 42 ítems con formato de respuesta dicotómica. Se realizó un análisis factorial confirmatorio a partir de la matriz de correlaciones tetracóricas. Esto permitió replicar la estructura propuesta por Eysenck para el modelo PEN (Psicoticismo-Extraversión-Neuroticismo) y la escala Sinceridad. Posteriormente, se ajustó el modelo logístico de dos parámetros por separado para los ítems de cada escala. Los ítems no mostraron funcionamiento diferencial según género. La discriminación de los ítems resultó moderada-alta. Los parámetros b se localizaron en rangos acotados de cada uno de los rasgos medidos, lo que originó que la precisión de las escalas varíe en el recorrido de los continuos. La escala Neuroticismo aporta más información en niveles medios del rasgo, Psicoticismo en los medio-bajos y Extraversión en los medio-altos. La escala Sinceridad mostró una función de información relativamente plana en todo el recorrido del rasgo. Se brindan evidencias de validez basadas en la relación con otras pruebas que miden facetas del neuroticismo y sintomatología. Las evidencias de validez y confiabilidad obtenidas ofrecen garantías de calidad suficientes para la aplicación de este instrumento en el contexto local y confirman la vigencia del modelo teórico que operacionaliza el EPQ-RS.
Procesamiento emocional en niños y adolescentes según sexo
Authors: Mina Leonel , Bakker Liliana , Rubiales Josefina , Funes Nicolas
Published: February 2022

Objetivo: analizar el procesamiento emocional en niños, niñas y adolescentes argentinos de edad escolar según sexo. Método: estudio descriptivo-comparativo con un diseño ex post facto, transversal. Participaron en la investigación 67 mujeres y 74 varones escolarizados de entre 7 y 14 años dividido en tres franjas etarias. Para evaluar el procesamiento emocional se utilizaron las 60 imágenes específicas para niños y adolescentes del International Affective Picture System (IAPS), y para medir los juicios evaluativos se utilizó el Self Assessment Manikin (SAM). Resultados: la distribución de las imágenes muestra una correlación moderada negativa entre dos dimensiones afectivas básicas del procesamiento emocional, la valencia afectiva y la activación fisiológica, con valores similares en ambos sexos. Las mujeres puntuaron más bajo que los varones en valencia y arousal, aunque sin diferencias estadísticamente significativas. Los varones evaluaron los estímulos aversivos con menor grado de activación y los estímulos agradables con mayor activación. En general, se observa mayor agrupamiento de las imágenes desagradables y neutras en las mujeres respecto de las de los varones. Conclusión: en ambos sexos se presentó una relación inversa entre valencia y arousal, evidenciada en mayor activación ante imágenes desagradables, lo cual demostraría una tendencia evitativa cuando los niveles de arousal son elevados. Las mujeres reaccionaron a las imágenes desagradables con mayor intensidad mientras que los varones, valoraron las imágenes agradables con mayor intensidad.
Regional characteristics’ impact on the performances of the gated recurrent unit on streamflow forecasting
Authors: Wang Qianyang , Zheng Yuexin , Yue Qimeng , Liu Yuan , Yu Jingshan
Published: February 2022

The gated recurrent unit (GRU) has obtained attention as a potential model for streamflow forecasting in recent years. Common patterns and specialties when employing it in different regions, as well as a comparison between different models still need investigation. Therefore, we examined the performances of GRU for one, two, and three-day-ahead streamflow forecasting in seven basins in various geographic regions in China from the aspect of robustness, overall accuracy, and accuracy of streamflow peaks’ forecasting. The robustness and accuracy of it are closely related to correlations between the input and forecasting target series. Also, it outperforms the benchmark machine learning models in more cases, especially for one-day-ahead forecasting (NSE of 0.88–0.96 except for the unsatisfactory result in the Luanhe River basin). The deterioration of its accuracy along the increasing lead time depends on the dominant time lags between the rainfall and streamflow peaks. Recommendations were proposed for further applications.
Insight into the performance and mechanism of magnetic Ni0.5Cu0.5Fe2O4 in activating peroxydisulfate for ciprofloxacin degradation
Authors: Wang Bo , Li Shifeng , Wang Haibo , Yao Shuhua
Published: February 2022

Magnetic nickel-copper ferrite (NixCuyFe2O4) nano-catalyst was synthesized by co-precipitation method, and it exhibited excellent ability for activating peroxydisulfate (PDS) in the degradation of ciprofloxacin (CIP). As-prepared Ni0.5Cu0.5Fe2O4 properties were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope equipped with an energy-dispersive X-ray (SEM-EDX), transmissions electron microscopy (TEM), N2 adsorption-desorption isotherm plot of Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH), vibrating sample magnetometer (VSM). The maximum degradation efficiency is 80.2% by using 0.500 g/L of Ni0.5Cu0.5Fe2O4 for activating 5.00 mmol/L of PDS to degrade CIP (20.0 mg/L) at 25 ± 2 °C for 50 min (pH = 6.00). The presence of interfering ions Cl−, NO3−, and HCO3− inhibited the reaction by producing reactive species with low oxidation potential, inducing the degradation efficiency down to 60.0%, 58.1% and 21.5% respectively. Ni0.5Cu0.5Fe2O4 displayed great magnetic separation characteristic for the satisfactory magnetization; saturation value is ∼8.6 emu/g. The degradation efficiency of recycled samples has no significant difference after using three times, which is about 60%, indicating that Ni0.5Cu0.5Fe2O4 is a reusability catalyst in activating PDS for CIP degradation. This work might provide an efficient and promising approach to construct recyclable magnetic materials that can be used for wastewater treatment.
ARQUITETURA MODERNA E EDUCAÇÃO
Authors: Moreira Fernando Diniz , Leão Silva de Souza Larissa Morgana
Published: February 2022

O presente artigo busca analisar a atual sede do Instituto de Educação de Pernambuco, complexo educacional moderno localizado em Recife-PE (Brasil), e as transformações pelas quais passou desde sua inauguração. O complexo é um exemplar notório da arquitetura moderna pernambucana por combinar diversos artifícios para a adaptação de princípios universais da arquitetura moderna à realidade bioclimática regional, e promover de forma bastante completa a integração de arquitetura, urbanismo e paisagismo, dada sua relação com o contexto urbano. Projetado pelos arquitetos Marcos Domingues e Carlos Corrêa Lima em 1956, ele se enquadra no contexto do período nacional-desenvolvimentista, refletindo a visão de atribuir à arquitetura moderna o papel de ferramenta para a transformação social, em consonância com a pedagogia emergente no período e os esforços no sentido da oferta de uma educação pública de qualidade. A análise parte de uma breve contextualização do histórico da instituição, passando pela escolha do terreno da nova sede, o concurso de arquitetura e sua construção, que destaca a relação do conjunto com o Parque Treze de Maio, um dos principais espaços livres públicos da cidade. Também é disposta a análise projetual do objeto, concentrada nas escolas Sizenando Silveira, Sylvio Rabello, Cônego Rochael de Medeiros e o Jardim Ana Rosa Falcão de Carvalho, edificações que compunham originalmente o conjunto e que apresentam qualidades arquitetônicas significativas. Por fim, é exposto um panorama geral das transformações ocorridas no conjunto da época de sua construção aos dias atuais, alertando para a necessidade da preservação patrimonial
OUVINDO O ESPAÇO
Authors: Silva Bruno Firmino Costa da , Amorim Luiz Manuel do Eirado
Published: February 2022

O artigo trata da relação entre arquitetura e música a partir do espaço como gerador e difusor das ondas sonoras, e tomando como objeto de interesse a dimensão espacial arquitetônica através das ideias compositivas e sonoras geradas a partir e com a música. Nessa relação entre os dois campos observou-se a troca, na qual arquitetura e música se influenciam mutuamente e até borram suas fronteiras onde o espaço é musical e a música é espacial. Argumenta-se que esse atravessamento mútuo se dá para além do léxico comum e das questões formais, encontrando o espaço como mediador. Para o desenvolvimento do estudo foram identificados exemplares históricos e paradigmáticos resultantes de novas teorias e inovações tecnológicas. Nesse contexto, a peça 4’33” do compositor John Cage foi utilizada. como objeto de estudo para discorrer sobre a relação imbricada com a qual música e arquitetura trazem a partir do espaço arquitetônico.
O FENÔMENO URBANO DA EDUCAÇÃO ONLINE
Authors: Gava Gustavo Luiz , Ultramari Clovis
Published: February 2022

Buscou-se, nesta pesquisa, apresentar uma insurgência urbana agravada pela pandemia do coronavírus e que ainda assola a Educação brasileira: a necessidade de trânsito no ciberespaço e o acesso à Educação online. O objetivo da pesquisa teve como proposta central apresentar a seguinte pergunta-problema: como seria possível projetar um ambiente virtual que valorizasse a relação afetiva e que buscasse promover a aprendizagem significativa? A proposta metodológica dessa pesquisa foi subdividida em três seções e por meio de natureza triangular: bibliográfica, qualitativa e exploratória. O resultado alcançado demostra que o ambiente virtual usado na Educação online apresenta dificuldades nas interações humanas, justamente porque a qualidade das experiências está vinculada aos modelos de relação humano-máquina de forma passiva e algumas vezes sem significado ao estudante. Em relação à pergunta-problema, foi considerada a relação afetiva entre os estudantes: a qualidade de acesso à Internet, a arquitetura pedagógica do ambiente virtual e a experiência neurocognitiva. Assim, foi possível destacar uma proposta de Objeto Digital de Aprendizagem (ODA) denominado “Conecta Mais” e que se encontra em fase piloto de implementação em uma instituição de ensino superior do estado do Paraná.
A CABANA PRIMITIVA
Authors: Feliciano Ana Marta
Published: February 2022

Durante os séculos XVIII e XIX e através da obra de um conjunto de arquitectos e pensadores, vai-se assistir a uma progressiva e efectiva consolidação da autonomia da arquitectura enquanto disciplina. Neste contexto, a cabana primitiva consistiu num importante referencial para a teorização da arquitectura. Um dos aspectos mais importantes desta teorização e reflexão em torno da cabana primitiva e da sua relação com a origem da arquitectura poderá ter consistido no progressivo entendimento da mesma, já não como objecto de imitação directa, mas sim como referencial ideal, processo que abriria caminho á construção da Modernidade e a uma evolução futura da arquitectura.
Metabolic Study of Benzamidenafil using Liquid Chromatography Quadrupole
Time-of-Flight Mass Spectrometry
Authors: Pyo Jaesung
Published: February 2022

Background:

Various illegal phosphodiesterase-5 (PDE5) inhibitors have been indiscriminately
added to food and dietary supplements since the early 2000s without evaluating
their side effects or pharmaceutical effects.

Objective:

The metabolic pathway of benzamidenafil was evaluated using liquid chromatography
quadrupole time-of-flight mass spectrometry (LC-Q-ToF-MS).

Methods:

In vitro metabolic samples were prepared using human liver microsomes, and in vivo
metabolic samples were obtained from drug-administered rats. The metabolic samples were extracted
to remove biological interferences and injected into the LC-Q-ToF-MS system for analysis.
Their mass spectra and chromatograms were compared and interpreted.

Results:

A total of nine metabolites were evaluated in the benzamidenafil-treated samples. All
error values were within 5 ppm with high accuracy.

Conclusion:

These newly identified metabolites of benzamidenafil could be used to construct
relevant legal databases and applied to related forensic cases.
Efficient One-pot Synthesis of 3,3-di(indolyl)indolin-2-ones from Isatin and Indole Catalyzed by VOSO4 as Non-Sulfonamide Carbonic Anhydrase Inhibitors
Authors: Swain Baijayantimala , Singh Priti , Angeli Andrea , Sahoo Santosh Kumar , Yaddanapudi Venkata Madhavi , T. Supuran Claudiu , Arifuddin Mohammed
Published: February 2022

Background:

A high yielding green protocol has been developed and delineated for the synthesis of 3,3-
di(indolyl)indolin-2-ones, potentially bioactive compounds, involving one pot aqueous medium condensation of isatin
with indole in the presence of VOSO4. The synthesized compounds were screened for their carbonic anhydrase inhibitory
activity against human (h) isoforms hCA I, hCA II, hCA IX, and hCA XII. These non-sulfonamide derivatives
selectively inhibited hCA II in the micromolar range.

Objective:

To develop a high yielding green protocol to synthesize 3,3-diindolyl oxindole derivatives using water as
solvent media and screening the synthesized molecules for their carbonic anhydrase inhibitory activity.

Methods:

The target compound is obtained by taking isatin, indole, VOSO4, and H2O in one-pot at 70oC.

Results:

The designed molecules were synthesized by using the new method. The molecules were screened for their
CA inhibitory activity, which shows selective inhibition toward hCA II.The result showed an excellent yield without
any loss or decrease in catalytic activity, proving the catalyst's performance and recyclability.

Conclusion:

An efficient, simple, and green protocol was established that provides a facile and straightforward approach for
the preparation of 3,3-diindolyl oxindole derivatives (3a-r) from Isatin and Indole by using 10 mol% VOSO4 in high yields in
a short period of time by a one-pot coupling reaction. Furthermore, the catalyst can also be recovered and reused for three
consecutive catalytic cycles without any loss of its efficiency, which was confirmed by performing the experiment with 3a.
The newly synthesized molecules (3a-r) were screened for their carbonic anhydrase inhibition potency against four isoforms,
hCA I, II, IX, and XII and most of the compounds were found potent against hCA II with potency low to submicromolar
range.
Multifactorial Assessment of Older Adults Able and Unable to Recover
Balance During a Laboratory-induced Trip
Authors: Bohrer Roberta Castilhos Detanico , Lodovico Angélica , Duysens Jacques , Rodacki André Luiz Felix
Published: February 2022

Background:

Older adults are prone to falls, and identifying fallers and non-fallers from
a set of fall-related variables is essential while establishing effective preventive programs.

Aims:

This study aimed to analyze if a set of parameters (i.e., strength, functional status, dynamic
balance, gait, and obesity-related anthropometric measures) differ between older adults able and
unable to recover from an induced trip.

Objective:

To analyze predictors among older adults able and unable to identify fallers and nonfallers.

Methods:

Thirty healthy old adults were tripped once during the mid-swing phase of the gait. The
trip outcome was used as a criterion to assign participants to a recovery (REC; n=21; 71.2±5.7
years; 70.9±12.8 kg; 1.60±0.09 m) or a non-recovery group (NREC; n=9; 69.4±6.8 years;
85.7±11.8 kg; 1.59±0.08 m). The spatiotemporal gait parameters, functional mobility, dynamic balance,
and isokinetic muscular function were measured.

Results:

The NREC presented larger BMI (33.6±2.7 vs. 27.5±3.4 kg.m-2; p<0.05); greater time for
the initiation phase on the voluntary step execution test (197.0±27.9 vs. 171.7±31.3s; p<0.05); lower
plantarflexor (0.41±0.15 vs. 0.59±0.18 N.m; p<0.05), dorsiflexor (0.18±0.05 vs. 0.24±0.07 N.m;
p<0.05), knee extensor (1.03±0.28 vs. 1.33±0.24 N.m; p<0.05) and knee flexor peak torques
(0.50±0.15 vs. 0.64±0.13 N.m; p<0.05); and greater time up and go (8.0±0.8 vs. 7.4±0.7 s).

Conclusions:

The results showed that it is possible to identify fall risk components based on several
fall-related parameters using a laboratory-induced trip as the outcome variable.
Randomized Clinical Trials on the Efficacy and Safety of Tocilizumab in
Subjects with Rheumatoid Arthritis: A Systematic Review
Authors: Elnour Asim Ahmed , Sadeq Adel , Ramadan Azza , Kidir Israa Yousif , Don Judit , Al Amoodi Abdulla , Al Mazrouei Nadia , Baraka Mohamed A. , Farah Farah Hamad , Alkaabi Maisoun
Published: February 2022

Background:

The current therapy of Rheumatoid Arthritis (RA) is confronted with many
challenges such as inadequate response, infection, and treatment failure.

Aim and Objective:

The main objective was to assess the efficacy and safety of tocilizumab (TCZ) in
subjects with RA using the available evidence from published randomized controlled trials.

Methods:

The current systematic review was performed on nine randomized controlled trials from 2002
to 2016 for TCZ in subjects with rheumatoid arthritis. The primary outcomes were the clinical improvement
in American College Rheumatology 20% (ACR20) or Disease Activity Score remission (DAS28),
in addition to other outcomes such as ACR50 and ACR70 in the intention-to-treat population.

Results:

We have conducted a systematic review on nine randomized controlled trials, with 4129
[100%] enrolled, of which 3248 [78.7%] were on the intention-to-treat. 2147 (66.1%) were treated
with TCZ and 1101 (33.9%) have had received placebo or methotrexate or other conventional Disease-
Modifying Anti-rheumatic Drugs (cDMARD) or biologic Disease-Modifying Anti-rheumatic
Drugs (bDMARDs). In subjects taking TCZ with or without concomitant methotrexate, compared to
placebo, subjects treated with TCZ 4 or 8 mg/kg were substantially and statistically significantly more
likely than placebo or methotrexate to achieve the ACR20 and/or DAS28. There were no statistically
significant differences in serious adverse events such as serious infection; however, subjects on TCZ
were more likely to have increased lipid profiles.

Conclusion:

TCZ mono-therapy or in combination with methotrexate is valuable in diminishing
rheumatoid arthritis disease activity and improving disability. Treatment with TCZ was associated
with a significant surge in cholesterol levels but no serious adverse effects. Randomized clinical trials
with safety as the primary outcome are warranted to report these safety issues.
influence of job satisfaction on organizational commitment and quality of inpatient services
Authors: Putri Ida Ayu Gede Swarini , Sintaasih Desak Ketut , Supartha Wayan Gede , Riana I Gede
Published: February 2022

The purpose of this study was to examine the effect of job satisfaction on organizational commitment, examine the effect of job satisfaction on service quality, examine the effect of organizational commitment on service quality, and to examine the mediation of Organizational Commitment on Job Satisfaction on Service Quality at the Wangaya Regional General Hospital. To examine the effect of job satisfaction on service quality at the Wangaya Regional General Hospital, this study used 135 Wangaya Hospital employees, especially those who served in the inpatient room as respondents using Path Analysis. The results of this study indicate that job satisfaction has a positive effect. and significant on service quality, job satisfaction has a positive and significant effect on organizational commitment, and organizational commitment is able to mediate the effect of job satisfaction on service quality at the Wangaya Regional General Hospital.
Feeling Guilt and Happiness Police of The Regional Traffic Management Center (RTMC) of The East Java Regional Police to Their Families (Phenomenology Study)
Authors: Wijaya Yunus Adi , Hariyanti Tita , Nasution Tina Handayani
Published: February 2022

Guilts is the first and foremost in the form of emotional outbursts. Guilts is not a very good motivator. It is more accurate to regard guilt as an internal condition and a negative feeling. Happiness is a feeling of satisfaction, that life is as it should be and all needs have fulfilled. This study aims to find meaning in the experience of feeling guilt and happiness police of the Regional Traffic Management Center (RTMC) to their families. Qualitative interpretive phenomenology approach was conducted an in-depth interview with semistructured questions on five police officers at RTMC by purposive sampling conducted in December 2018. Based on Interpretative Phenomenological Analysis (IPA), this study found two themes namely: feeling guilty to the family and feeling happy with family. The findings obtained were that members of the police at RTMC could be free from stress while working and were able to return and get support from the family. Being able to live happily, both happy at work and happy with the family that will reflect in the calmness in their life.
IMPLEMENTASI PEMBELAJARAN KREATIF SENI RUPA ANAK PAUD BERBASIS DARING
Authors: Wibowo Devi Vionitta , Nugraheni Aninditya Sri
Published: February 2022

Kreativitas menjadi salah satu fokus utama pendidikan abad 21. Karena itu, penelitian ini mencoba menganalisis bagaimana implementasi pembelajaran kreatif seni rupa pada tingkat PAUD secara daring. Metode penelitian berbentuk kualitatif studi kasus pada Lembaga PAUD Masyithoh Rembang. Hasil penelitian menyatakan bahwa pembelajaran kreatif seni rupa dirangkum dalam silabus kurikulum darurat milik lembaga yang dibuat melalui program harian yang pelaksanaanya melalui Facebook, Youtube, Video Call, dan WhatsApp. Kegiatan seni rupa dua dimensi berupa kegiatan melukis serta seni tiga dimensi yang berupa karya membuat wayang binatang, mainan kacamata, gambar ikan dari barang bekas, kolase, serta bentuk rumah dari plastisin. Evaluasi yang didapat adalah anak dapat mengikuti kegiatan pembelajaran dengan baik dan melalui kegiatan ini dapat meningkatkan aspek perkembangan anak yang terdiri dari kognitif, sensorimotorik, bahasa, emosional serta bakat dan kreativitas anak.   Kata Kunci: Pembelajaran, Kreatif, Seni Rupa, PAUD, Daring  IMPLEMENTATION OF ONLINE-BASED PAUD CHILDREN’S CREATIVE ARTS LEARNINGAbstract        Creativity is one of the main focuses of 21st-century education. Therefore, this study tries to analyze how the implementation of fine arts online creative learning at PAUD level. The research method is in the form of a qualitative case study at the PAUD Masyithoh Institute, Rembang. The results of the study stated that creative art learning was summarized in the institution’s emergency curriculum syllabus, which was made through daily programs whose implementation was through Facebook, Youtube, Video Call, and WhatsApp. Two-dimensional art activities in the form of painting activities and three-dimensional art in the form of making animal puppets, glasses, toys, fish pictures from used goods, collages, and the shape of houses from plasticine. The evaluation obtained is that children can participate in learning activities well. Through these activities can improve aspects of child development consisting of cognitive, sensorimotor, language, emotional, and children’s talents and creativity.. Keywords: Learning, Creative, Fine Art, PAUD, Online
MUSIK TRADISIONAL KURIDING DI DESA ULU BENTENG KECAMATAN MARABAHAN KABUPATEN BARITO KUALA: BENTUK DAN FUNGSI PERTUNJUKAN
Authors: Sani Muhammad Budi Zakia
Published: February 2022

Penelitian ini bertujuan untuk mengetahui bagaimana sejarah lahir dan perkembangan Musik Tradisional Kuriding di Desa Ulu Benteng Kecamatan Marabahan Kabupaten Barito Kuala. Metode penelitian yang digunakan yaitu deskriptif  kualitatif dengan instrumen yaitu peneliti, perekam suara, kamera dan video. Teknik pengumupulan data yang dilakukan adalah studi lapangan atau observasi, studi dokumentasi, dan wawancara. Analisis data menggunakan teknik deskriptif analisis dengan tahap pengumpulan data, klasifikasi, dan deskripsi data serta analisis data. Hasil penelitian menunjukan bahwa Syamsudin (Alm) adalah orang yang pertama kali memainkan atau sebagai maestro kuriding di desa tersebut, berdasarkan paparan oleh Iwie, kuriding pertama kali ia ketahui setelah ia menikah dengan Syamsuddin sekitar tahun 1930an. Perkembangan kuriding di desa Ulu Benteng tidak mengalami perkembangan. Kuriding mengalami kemunduran dan hanya ditemukan empat orang saja yang masih bisa memainkan Kuriding dengan fakta mereka tidak mampu membuat alat musik tersebut. Bentuk musik kuriding ini adalah pertunjukan yang dilakukan secara perorangan atau kelompok. Fungsi musik yang terdapat dalam musik kuriding diantara adalah sebagai sarana hiburan pribadi, sebagai sarana presentasi estetis, dan juga sebagai sarana pengikat solidaritas masyarakat.Kata Kunci : Kuriding, Musik Tradisional, Bentuk dan Fungsi PertunjukanKURIDING TRADITIONAL MUSIC IN ULU BENTENG VILLAGE, MARABAHAN DISTRICT, BARITO KUALA REGENCY: FORM AND FUNCTION OF PERFORMANCE Abstract               The purpose of this study is to trace the history of Kuriding Traditional Music in Ulu Benteng Village, Marabahan District, Barito Kuala Regency. The method of study involves descriptive qualitative instruments, such as researchers, voice recorders, cameras, and videos. Field studies or observations, documentation studies, and interviews were all utilized to obtain data. Data analysis employs descriptive analytic techniques during the data collection, classification, and description stages of data collecting and analysis. The findings indicated that Syamsudin (Alm) was the first individual in the village to play or serve as a maestro of kuriding. According to Iwie, the first kuriding was known following her marriage to Syamsuddin in the 1930s. Kuriding's development in Ulu Benteng village remained stagnant. Kuriding suffered a setback when they discovered just four persons who could still play Kuriding due to their inability to manufacture the instrument. This style of kuriding music can be played solo or in groups. Kuriding music serves a variety of goals, including personal entertainment, aesthetic presentation, and community solidarity. Keywords: Kuriding, Traditional Music, Form and Functions of Performance
A Study of the Effect of Sound Therapy in People with Mild Tinnitus
Authors: Sim YeonWoo , Lee TaeRim , Jin In-Ki
Published: February 2022

Purpose: Tinnitus refers to the maladaptive perception of sound in the absence of external sounds. Sound therapy is a representative rehabilitation option that has been used to relieve the adverse effects of tinnitus. It helps to reduce the discomfort caused by tinnitus by providing various external background noises to those suffering from tinnitus. The purpose of this study was to identify the effects of sound therapy on tinnitus relief in people with mild tinnitus.Methods: Twelve participants with mild tinnitus participated in this study. Sound therapy was performed for 3 months using a customized mobile phone application. Broadband noise was used as the sound therapy stimulus. The level of stimulus was set to the level of the mixing point. The Korean version of the Tinnitus Primary Function Questionnaire (K-TPFQ) score, Visual Analogue Scale (VAS) score, and tinnitus loudness level were recorded as outcome measurements at baseline and 3 months.Results: There were no significant differences in the K-TPFQ and VAS scores and tinnitus loudness level between the baseline and 3-month follow-up session.Conclusion: The results of this study showed that sound therapy alone for 3 months does not provide significant tinnitus relief in participants with mild tinnitus. Therefore, considering only sound therapy for rehabilitation in people with mild tinnitus might not be ideal for providing relief.
Efficacy of Immersive Virtual Reality-Based Cognitive Training in Older Adults with Hearing Impairment: Three Case Reports
Authors: Lee Soo Jung , Lee Sungmin
Published: February 2022

The purpose of this study was to investigate the effects of immersive virtual reality (VR)-based cognitive training in older adults with hearing impairment. Participants were three older adults with hearing impairment. Three assessment tools, audiometric, neuropsychological, and outcome measurements of the subjective hearing handicap inventory for the elderly, were examined before and after the VR cognitive training. The VR cognitive training was conducted once per week for 6 weeks and consisted of five different VR games classified into three specific cognitive domains (attention, memory, and executive function). The improved VR game performances were constantly observed across the training sessions in all three participants. After the VR cognitive training, first, the scores on the forward digit span test (attention), immediate recall on the SVLT-E (memory), and word reading and color reading on the K-CWST (executive function) were improved for all participants. In addition, the reaction time on the K-TMT-E (executive function) was shortened. Second, the sentence recognition scores in adverse listening conditions (SNR 0 dB and -5 dB) were improved. Third, the Korean version of hearing handicap inventory for the elderly (K-HHIE) scores which are reflective of subjective hearing handicap were decreased. Preventive intervention for cognitive deficits in older adults with hearing impairment is needed because hearing impairment is one of the major risk factors for dementia in older age. In this respect, the present case study demonstrates that VR cognitive training could improve cognitive function, speech-in-noise perception, and subjective hearing handicap in the hearing-impaired elderly.
Adoption of a Postoperative Pain Self-Report Tool: Qualitative Study
Authors: Thiel Bram , Iao Inez , Smid Joris , de Wit Emmy , Koopman Seppe , Geerts Bart , Godfried Marc , Kalkman Cor
Published: February 2022

Background

With electronic technologies, patients are provided with tools to easily acquire information and to manage and record their own health status. eHealth interventions are already broadly applied to perioperative care. In a similar way, we aimed to utilize a smartphone application to enable postoperative patients to partially self-manage their postoperative pain. The results of a previously performed proof-of-concept study regarding the application were promising, and nurses as well as patients were optimistic regarding this innovative mobile application. Nevertheless, in reality, it appears that the usage and overall implementation of this application have stagnated since its introduction. Problems with innovation adoption are not novel; various studies have been conducted to explore the reasons for low implementation success of eHealth applications and indicated that adoption is influenced by multiple organizational factors. This study investigated the influence of these organizational factors on the adoption process, aiming to provide more insight in the dos and don’ts for implementing eHealth in the working processes of hospital care.

Objective

This study aimed to provide insight in how to successfully implement a technological eHealth innovation in a general nonacademic hospital.

Methods

A qualitative study was conducted to explore organizational factors affecting the innovation adoption process. Data were collected by conducting semistructured one-on-one interviews with 11 stakeholders. The data were analyzed using thematic analysis identifying overarching themes.

Results

Absorptive capacity, referred to as an organization’s dynamic capability pertaining to knowledge creation and utilization that enhances an organization’s ability to gain and sustain a competitive advantage, was regarded as the most influential factor on the application’s adoption. Accordingly, it appeared that innovation adoption is mainly determined by the capability and willingness to assimilate and transform new information into productive use and the ability to absorb a novel innovation. Absorptive capacity was found to be influenced by the innovation’s benefit and the sense of ownership and responsibility. Organizational readiness and management support were also regarded as essential since absorptive capacity seemed to be mediated by these factors. The size of the hospital influenced eHealth adoption by the amount of resources available and by its organizational structure.

Conclusions

In conclusion, absorptive capacity is essential for eHealth adoption, and it is mediated by management support and organizational readiness. It is recommended to increase the degree of willingness and ability to adopt an eHealth innovation by enhancing the relevance, engaging stakeholders, and assigning appropriate leaders to offer guidance.
Telehealth Services for Substance Use Disorders During the COVID-19 Pandemic: Longitudinal Assessment of Intensive Outpatient Programming and Data Collection Practices
Authors: Gliske Kate , Welsh Justine W , Braughton Jacqueline E , Waller Lance A , Ngo Quyen M
Published: February 2022

Background

The onset of the COVID-19 pandemic necessitated the rapid transition of many types of substance use disorder (SUD) treatments to telehealth formats, despite limited information about what makes treatment effective in this novel format.

Objective

This study aims to examine the feasibility and effectiveness of virtual intensive outpatient programming (IOP) treatment for SUD in the context of a global pandemic, while considering the unique challenges posed to data collection during an unprecedented public health crisis.

Methods

The study is based on a longitudinal study with a baseline sample of 3642 patients who enrolled in intensive outpatient addiction treatment (in-person, hybrid, or virtual care) from January 2020 to March 2021 at a large substance use treatment center in the United States. The analytical sample consisted of patients who completed the 3-month postdischarge outcome survey as part of routine outcome monitoring (n=1060, 29.1% response rate).

Results

No significant differences were detected by delivery format in continuous abstinence (χ22=0.4, P=.81), overall quality of life (F2,826=2.06, P=.13), financial well-being (F2,767=2.30, P=.10), psychological well-being (F2,918=0.72, P=.49), and confidence in one’s ability to stay sober (F2,941=0.21, P=.81). Individuals in hybrid programming were more likely to report a higher level of general health than those in virtual IOP (F2,917=4.19, P=.01).

Conclusions

Virtual outpatient care for the treatment of SUD is a feasible alternative to in-person-only programming, leading to similar self-reported outcomes at 3 months postdischarge. Given the many obstacles presented throughout data collection during a pandemic, further research is needed to better understand under what conditions telehealth is an acceptable alternative to in-person care.
Personalized Help-Seeking Web Application for Chinese-Speaking International University Students: Development and Usability Study (Preprint)
Authors: Choi Isabella , Mestroni Gemma , Hunt Caroline , Glozier Nick
Published: February 2022

BACKGROUND

The mental health of international students is a growing concern for education providers, students, and their families. Chinese international students have low rates of help seeking owing to language, stigma, and mental health literacy barriers. Web-based help-seeking interventions may improve the rate of help seeking among Chinese international students.

OBJECTIVE

This study aimed to describe the development of a mental well-being web app providing personalized feedback and tailored psychoeducation and resources to support help seeking among international university students whose first language is Chinese and test the web application’s uptake and engagement.

METHODS

The bilingual MindYourHead web application contains 6 in-app assessments for various areas of mental health, and users are provided with personalized feedback on symptom severity, psychoeducation tailored to the person’s symptoms and information about relevant interventions, and tailored links to external resources and mental health services. A feasibility study was conducted within a school at the University of Sydney to examine the uptake and engagement of the web application among Chinese international students and any demographic characteristics or help-seeking attitudes or intentions that were associated with its engagement.

RESULTS

A total of 130 Chinese international students signed up on the web application. There was an uptake of 13.4% (122/908) in the schools’ Chinese student enrollment. Most participants (76/130, 58.5%) preferred to use the web application in Chinese and used informal but not formal help for their mental health. There was considerable attrition owing to a design issue, and only 46 students gained access to the full content of the web application. Of these, 67% (31/46) of participants completed 1 or more of the in-app mental well-being assessments. The most commonly engaged in-app assessments were distress (23/31, 74%), stress (17/31, 55%), and sleep (15/31, 48%), with the majority scoring within the moderate- or high-risk level of the score range. In total, 10% (9/81) of the completed in-app assessments led to clicks to external resources or services. No demographic or help-seeking intentions or attitudes were associated with web-application engagement.

CONCLUSIONS

There were promising levels of demand, uptake, and engagement with the MindYourHead web application. The web application appears to attract students who wished to access mental health information in their native language, those who had poor mental health in the past but relied on informal support, and those who were at moderate or high risk of poor mental well-being. Further research is required to explore ways to improve uptake and engagement and to test the efficacy of the web application on Chinese international students’ mental health literacy, stigma, and help seeking.
Estimation of Out-of-Pocket Expenditure on COVID-19 Management Among Patients Treated at Home, Iraq, 2020 (Preprint)
Authors: Abdul kader Saeed Falah , Lami Faris
Published: February 2022

BACKGROUND

There is a global consensus that the socioeconomic impact of the COVID-19 crisis has had a substantial effect on health programs and health insurance, with losses of jobs and rising prices causing growing poverty.

OBJECTIVE

This study aims to estimate the out-of-pocket expenditure spent on the management of patients with COVID-19 exclusively treated at home.

METHODS

A cross-sectional study was conducted, and data were collected from participating patients with COVID-19 in Iraq through snowball sampling by using a questionnaire. Enrollment occurred from November 1 to December 31, 2020, and excluded individuals who were entering the hospitals.

RESULTS

Among 589 participating patients with COVID-19, 328 (55.7%) were female. Female patients spent more than male patients to get cured of the illness; the mean amount of money spent by women was statistically higher than men (IQD 644,617 [US $402] and IQD 461,653 [US $307], respectively). The average total money expenditures spent was IQD 643,304 (US $428; range IQD 505,096-5,595,000 [US $336-US $3730]) among patients exclusively treated at home. The average money spent by patients with inadequate monthly income (IQD 901,424 [US $600], range IQD 220,000-5,260,000 [US $140-US $3500]) was significantly more than patients with adequate monthly income (IQD 613,252 [US $400], range IQD 48,000-5,500,000 [US $32-US $3600]). Patients with COVID-19 (25.5%) who had chronic diseases spent significantly more money (IQD 696,330 [US $460]) than those without the chronic disease (IQD 625,185 [US $416]).

CONCLUSIONS

Financial burdens affected the purchasing power and the economic situation on the management of patients with COVID-19 exclusively treated at home.
Evaluation of the Nutrition Surveillance System, Sana’a City, Yemen, 2021: Cross-sectional Study (Preprint)
Authors: Alturki Sumia Abbas , Al-Mahdi Abdulfattah , Al-Sharafy Nosiba , Ghaleb Yasser
Published: February 2022

BACKGROUND

Malnutrition remains one of the most common causes of morbidity and mortality among children in low- and middle-income countries. It is one of the important problems that showed an increasing incidence in Yemen. The Nutrition Surveillance System started in 2018 as a pilot in five governorates to ensure that difficulties of public health importance are monitored efficiently.

OBJECTIVE

This study aims to assess its usefulness and the performance of the system attributes, and to identify strengths and weaknesses to make recommendations for improvement.

METHODS

The Centers for Disease Control and Prevention’s updated guidelines for the evaluation of public health surveillance were used to evaluate the Nutrition Surveillance System in Sana’a City. Qualitative and quantitative attributes were measured through desk review and in-depth interviews with stakeholders from different levels by using a semistructured questionnaire for collected data. The percent mean of total scores was used for the final rank of the performance as very poor (<40%), poor (40%<60%), average (60%<80%), good (80%<90%), and excellent (≥90%). Epi Info version 7.2 was used for data entry and analysis.

RESULTS

The Nutrition Surveillance System was found to be useful and flexible, with overall scores of 100% and 80%, respectively, and the overall system performance was average (76%). The highest attribute score was 83% for simplicity, and the lowest score was 67% for stability. Simplicity and acceptability at the governorate and district levels were good, but at the health facilities level, they were average. Timeliness of report and completeness of forms and data were 100% and 95%, respectively. The main strength of the Nutrition Surveillance System was continuous expansion in opening new health facilities and that the quality of data was strong with updated databases.

CONCLUSIONS

The Nutrition Surveillance System in Sana’a City was found to be useful and met its main objective. Overall levels of system performance were average. Regular training for health staff at the health facilities and gradual replacement of donors with government funds are recommended.
Parent fruit and vegetable consumption outcomes from the translational ‘Time for Healthy Habits’ trial: Secondary outcomes from a partially randomized preference trial (Preprint)
Authors: Wyse Rebecca , Jackson Jacklyn , Hammersley Megan , Stacey Fiona , Jones Rachel , Xu Joe , Okely Anthony , Green Amanda , Yoong Sze Lin , Lecathelinais Christophe , Rissel Chris , Innes-Hughes Christine , Gillham Karen , Wolfenden Luke
Published: February 2022

BACKGROUND

Parents are the primary decision makers of the foods prepared and offered to children. There is a strong association between parent and child fruit and vegetable intakes. Healthy eating and active living interventions targeting parents of young children could have benefits for both children and parents, however there is currently limited evidence demonstrating this effect when the intervention is offered to the community remotely (using digital technologies i.e. telephone or online) as part of existing preventive health services.

OBJECTIVE

To assess the effectiveness of two digital interventions (computer-assisted telephone or online) healthy eating and active living interventions delivered at scale to parents of children aged 2-6 years, for increasing parent fruit and vegetable consumption (secondary outcome) at 9-months post baseline.

METHODS

Parents (n=458) were recruited to a partially randomized preference trial comprising of three arms: 1. Computer-assisted telephone intervention; 2. Online intervention; 3. Written material (Control). This design allowed parents with a strong preference to select their preferred intervention and once preference trends were established, parents were randomized to obtain robust relative effects. Data were analyzed for randomized participants, preference participants and all participants.

RESULTS

At 9-months post-baseline, parents randomized to the computer-assisted telephone intervention (n=73) had significantly higher vegetable consumption compared with parents randomized to the control (n=81) (+0.41 serves/day (95% CI: 0.02 to 0.81), p=0.04). However, there were no differences in vegetable consumption between parents who chose the computer-assisted telephone intervention (n=22) compared to those who chose the control (n=64) (preference participants). No differences in parent fruit consumption were found for randomized or preference participants for either the computer-assisted telephone or online intervention. Similarly, analysis of all participants combined found no differences in parent consumption of fruit or vegetables between either the computer-assisted telephone (n=95) or online (n=218) intervention group compared with the control (n=145).

CONCLUSIONS

There may be some benefit to parents participating in computer-assisted telephone interventions aimed at improving the eating behaviors of their children. Future research is recommended to explore methods for optimizing parent engagement with technology-based interventions, to enable greater health benefits for both parents and their children.

CLINICALTRIAL

UTN: U1111-1228-9748, ACTRN: 12619000396123