bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the chemotherapy effect of albumin-bound paclitaxel combined with pirarubicin and cyclophosphamide on breast cancer and the effects of PCR, ORR, and CBR
Authors: Liu Youzhong , Gong Ke , Yuan Songlin , Xu Yong
Published: February 2025

Objective: To explore the chemotherapy effect of albumin-bound paclitaxel combined with pirarubicin and cyclophosphamide on breast cancer and the effects of PCR, ORR and CBR.
Methods: This was a retrospective study. During the period from January 2022 to December 2023, ninety patients with breast cancer who were treated in The First People’s Hospital of Changde City were included as the research objects. Based on the principle of randomized control, the above patients were divided into the control group (45 cases, treated with pirarubicin and cyclophosphamide) and the observation group (45 cases, treated with albumin-bound paclitaxel combined with pirarubicin and cyclophosphamide) by the random number table. Compared the chemotherapy effect and safety of the two groups.
Results: After treatment, the PCR, ORR and CBR of the observation group were higher than those of the control group, while the levels of CA152, CA125, TPS, HER-2, Ki-67 and EGFR were lower than those of the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions was 33.33% (15/45), which was slightly higher than that of 28.89% (13/45) in the control group, the difference was not statistically significant (P>0.05).
Conclusion: Albumin-bound paclitaxel combined with pirarubicin and cyclophosphamide is a safe regimen that can further enhance the effect of neoadjuvant chemotherapy in the treatment of breast cancer, and it has a certain value for dissemination in the treatment of breast cancer can further enhance the effect of neoadjuvant chemotherapy in patients, which is of certain value for clinical promotion.
doi: https://doi.org/10.12669/pjms.41.3.9861
How to cite this: Liu Y, Gong K, Yuan S, Xu Y. Analysis of the chemotherapy effect of albumin-bound paclitaxel combined with pirarubicin and cyclophosphamide on breast cancer and the effects of PCR, ORR, and CBR. Pak J Med Sci. 2025;41(3):769-773.  doi: https://doi.org/10.12669/pjms.41.3.9861
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
High ceftazidime-avibactam resistance rate in carbapenem-resistant gram-negative organisms in Pakistan’s pediatric population
Authors: Mehdi Naima , Majeed Nadia , Ali Farwa , Aroob Iqra
Published: February 2025

Objective: This study investigates resistance to a newly available drug Ceftazidime–Avibactam (CAZ-AVI) in carbapenem-resistant gram-negative organisms (GNOs) in the Pakistan’s pediatric population.
Methods: This was a prospective study carried out in the Department of Microbiology at The Children’s Hospital, Lahore from May 2023 to July 2023. A sum of 7491 specimens of blood, cerebrospinal fluid (CSF), urine, pus, nasal swabs, central venous catheter (CVP) tips and tracheal secretion were analyzed for presence of carbapenem resistant gram-negative organisms which were then further screened for CAZ-AVI resistance. Analytical profile index and Kirby-Bauer disk diffusion methods were used for the identification of organisms.
Results: A total of 217(n) carbapenem-resistant bacterial species, including 165(n) Klebsiella sp., 32(n) Pseudomonas sp., and 20(n) Escherichia coli (E. coli) strains, were tested for sensitivity against CAZ–AVI. Approximately, 70.5% (153 out of 217) of carbapenem-resistant bacteria exhibited resistance to CAZ-AVI. Among the resistant bacterial species, 80% (122/153) were Klebsiella sp., 14% (21/153) were Pseudomonas sp., and 6% (10/153) were E. coli. These findings suggest pre-existing resistance mechanisms may be responsible for exhibiting resistance to CAZ-AVI in these organisms.
Conclusion: Taking into account the results of this study, which depicted high resistance rates to CAZ-AVI among carbapenem resistant GNOs, and the high cost of this drug, it is suggested that a cautious selection for its use as monotherapy in sepsis and other infections should be made. It should be made mandatory to check the resistance to CAZ-AVI before its empiric use. The findings of the study also emphasize the challenges of combating new drug resistance and further research to adapt treatment strategies to the evolving antimicrobial resistance in the region.
doi: https://doi.org/10.12669/pjms.41.3.9978
How to cite this: Mehdi N, Majeed N, Ali F, Aroob I. High ceftazidime-avibactam resistance rate in carbapenem-resistant gram-negative organisms in Pakistan’s pediatric population. Pak J Med Sci. 2025;41(3):788-791. doi: https://doi.org/10.12669/pjms.41.3.9978
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The role of Friend of GATA1 FOG-1 in erythropoiesis
Authors: Ρούσσης Ιωάννης-Μάριος
Published: February 2025

Κατά τη διάρκεια της διπλωματικής μου εργασίας, επικεντρώθηκα στον ρόλο του συγγραφικού συντελεστή Φίλος του GATA1 (FOG-1) στα θηλαστικά, μελετώντας τις λειτουργίες του FOG-1 στον έλεγχο της ερυθροποίησης στα ποντίκια. Ο εντοπισμός νέων εταίρων που αλληλεπιδρούν με τον μεταγραφικό παράγοντα FOG-1 και η μοριακή τους λειτουργία θα παρέχουν εναν λεπτομερή χαρακτηρισμό, ο οποίος είναι απαραίτητος για μια καλύτερη κατανόηση των μοριακών μηχανισμών που υποκείνται στη λειτουργία του στην αιματοποίηση. Για τον σκοπό αυτό, Το Κεφάλαιο 3 παρέχει μια επισκόπηση των πρωτεΐνων που αλληλεπίδρουν με το FOG-1 στα Murine erythroleukemia (MEL) κύτταρα και παρέχει αποδείξεις ότι ο FOG-1 λειτουργεί ως ενδιάμεσος για το CTCF και τα Cohesins στα ερυθροειδή κύτταρα.Το Κεφάλαιο 4 επικεντρώνεται στο να κατανοήσει τη μοριακή βάση των λειτουργιών του FOG-1 στην ερυθροειδή διαφοροποίηση, επομένως δημιούργησα μια μόνιμη γραμμή κυττάρων MEL με απενεργοποιημένο FOG-1 χρησιμοποιώντας το CRISPR/Cas9. Στη συνέχεια, προχώρησα στη χαρακτηρισμό του φαινοτύπου αυτής της πρόσφατα δημιουργηθείσας κυτταρικής γραμμής, ακολουθούμενη από σύγκριση του προφίλ έκφρασης RNA της με αυτό των κανονικών κυττάρων MEL. Το Κεφάλαιο 5 ακολουθεί το Κεφάλαιο 4, όπου η ανάλυση προφίλ RNA-seq της γραμμής κυττάρων FOG-1 KO προκάλεσε το ενδιαφέρον μας, καθώς η απενεργοποίηση του FOG-1 έδειξε ότι η βιοσύνθεση και η μεταφορά της χοληστερόλης (εισροή και εκροή) απορυθμίστηκαν στο επίπεδο του RNA. Αυτή η νεοαναγνωρισμένη λειτουργία του FOG-1 στον έλεγχο της ομοιόστασης της χοληστερόλης εξετάστηκε περαιτέρω με πρωτεομικές, φαινοτυπικές και λειτουργικές αναλύσεις σε αυτό το κεφάλαιο. Στο τελευταίο Κεφάλαιο 6, συνοψίζονται τα αποτελέσματα που παρουσιάζονται σε αυτή τη διατριβή και συζητείται εν συντομία η μελλοντική προοπτική της έρευνας για τη ρύθμιση της διαφοροποίησης διακριτών αιμοποιητικών γραμμών από το FOG-1.
Ανάλυση λόγου σε σύγχρονα γεγονότα που επηρέασαν τις σχέσεις Ελλάδας και Αλβανίας
Authors: Γκούρης Διονύσιος
Published: February 2025

Η παρούσα διδακτορική διατριβή εστιάζει στην ανάλυση του ακροδεξιού λόγου που κανονικοποιήθηκε μέσω της κάλυψης δύο συγκεκριμένων συμβάντων, τα οποία αφορούν την Ελλάδα και την Αλβανία, από τα mainstream Μέσα και mainstream δημόσια πρόσωπα. Σε αυτό το πλαίσιο, η έρευνα εξετάζει πώς οι ακροδεξιές αφηγήσεις και τα στερεότυπα που αναδείχθηκαν μέσω των ερμηνειών αυτών των γεγονότων συνέβαλαν στη διαμόρφωση και ενίσχυση του ακροδεξιού λόγου, αναλύοντας παράλληλα τους μηχανισμούς που οδήγησαν στην κανονικοποίησή του στον δημόσιο διάλογο. Η μεθοδολογική προσέγγιση της διατριβής βασίζεται στην ανάλυση λόγου, συνδυάζοντας θεωρίες του κονστρουξιονισμού και της Σχολής του Έσεξ. Επιπλέον, αξιοποιούνται νοητικά εργαλεία από τη γλωσσολογία, την ψηφιακή ανάλυση κειμένων, καθώς και προσεγγίσεις των διεθνών σχέσεων. Μέσα από την παραπάνω πολυπρισματική μελέτη του ακροδεξιού λόγου, που αξιοποιείται για την ανάλυση του τρόπου με τον οποίο τα mainstream Μέσα και δημόσια πρόσωπα ερμήνευσαν τα συγκεκριμένα συμβάντα, στόχος είναι η κατανόηση της κατασκευής στερεοτυπικών αντιλήψεων, εχθρικών ταυτοτήτων, εθνοτικού εθνικισμού και της κανονικοποίησης του ακροδεξιού λόγου. Η έρευνα διερευνά τους τρόπους με τους οποίους οι συγκεκριμένες αφηγήσεις παγιώνονται στον δημόσιο λόγο, επηρεάζοντας τη διαμόρφωση των εθνικών ταυτοτήτων και των διακρατικών σχέσεων. Συμπερασματικά, η διατριβή επιδιώκει να συνεισφέρει ουσιαστικά στην ακαδημαϊκή μελέτη της κανονικοποίησης του ακροδεξιού λόγου, ανοίγοντας παράλληλα νέους δρόμους για μελλοντικές έρευνες.
The Pioneering Contributions of Martin K. Starr, Editor-in-Chief of Management Science (1967–1982)
Authors: Loch Christoph , Singhal Kalyan , Tang Christopher
Published: February 2025

Martin K. Starr, aged 97, passed away January 25, 2025. During his 15-year tenure as editor-in-chief of Management Science, he became the longest serving editor of any INFORMS journal. During this period, he published dozens of books and more than 100 articles. Starr made significant contributions to delineating the domain of modern operations and supply chain management, building a framework for system integration, modular design and production, and high-risk systems. This essay intends to underscore Martin Starr’s contributions to the field of management science, particularly emphasizing the crucial connection between theoretical analysis and practical applications in management.
Characterization of fillets and skins from two varieties of genetically improved farmed Nile tilapia (Oreochromis niloticus)
Authors: Campos Vinicius José , Gasparino Eliane , Lima Júnior José Wellington Rodrigues , Khatlab Angélica de Souza , Bastos Marisa Silva , Santana Thais Pacheco , Almeida Fernanda Losi Alves , de Souza Maria Luiza Rodrigues , Matiucci Marcos Antonio , Oliveira Gislaine Gonçalves , Oliveira Carlos Antonio Lopes de , Ribeiro Ricardo Pereira , Schlotefeldt Carolina , Oliveira Isis Regina Santos de , Oliveira Julia Gasparino de , Del Vesco Ana Paula
Published: February 2025

Genetically improved farmed tilapia (GIFT) is a strain of Nile tilapia (Oreochromis niloticus) developed for improved production and commercial parameters. Skin color, one of the characteristics distinguishing tilapia varieties, is an important phenotypic trait associated with qualitative and productive performance. This study aimed to assess fillet and skin characteristics in GIFT Nile tilapia with black and red skin phenotypes. For this, 24 GIFT Nile tilapia from the same spawning stock were divided into two groups based on skin color, namely a black variety (dark skin) and a red variety (reddish skin). There were no significant differences in biometric parameters between varieties. Fish of the red variety had higher 2 h post-slaughter pH and muscle antioxidant capacity and lower yellow-blue axis value (b*), luminosity (L*), thawing loss, cooking loss, and conjugated diene content (P < 0.05). The skin of black tilapia exhibited higher force in the progressive tear test tear, and higher strength, tensile strength, deformation, and elongation in the traction and stretching test than that of red tilapia. Black tilapia skin had higher collagen and hydroxyproline contents. The skin of the red variety exhibited higher expression levels of alpha 1, 2, and 3 type I collagen genes, lower expression levels of the vimentin gene, and higher antioxidant capacity. The results suggest that skin color phenotype may be linked to important metabolic pathways influencing fish fillet and skin traits. These findings can support future research aimed at identifying optimal varieties of Nile tilapia for specific purposes and optimizing the utilization of filleting waste.
Por um outro princípio de realidade: novos lugares e motivos sociais da negação segundo Herbert Marcuse
Authors: Schütz Rosalvo
Published: February 2025

Por um outro princípio de realidade: novos lugares e motivos sociais da negação segundo Herbert Marcuse
Resumo: Segundo Marcuse, a identificação do proletariado industrial como sendo o único sujeito de transformações sociais efetivas no capitalismo não se coaduna mais com a realidade. Essa convicção o levou a buscar ampliar o próprio conceito de negação herdado da tradição marxiana. Apoiado e superando a teoria freudiana do "princípio de realidade", Marcuse desenvolveu uma teoria de transformação social baseada em aspectos qualitativos, centrados na capacidade de subsidiar novos princípios de realidade que não o capitalista. Julgou encontrar alguns desses aspectos potencialmente revolucionários em temas como a sensibilidade, a estética, os movimentos sociais e na transformação radical das próprias necessidades e aspirações.
Palavras-chave: Princípio de desempenho. Mudança qualitativa. Reabilitação instintiva.
Por um outro princípio de realidade: novos lugares e motivos sociais da negação segundo Herbert Marcuse 
Abstract: In accordance with Marcuse, the industrial proletariat identification as the only subject of effective social transformations in capitalism does not correspond with the reality. This conviction took him to magnify his own negation concept inherited from Marx’s tradition. He supported and overcame Freud’s reality principle theory; Marcuse developed a social transformation theory based on qualitative aspects, centered in the ability to subside new reality principles other than the capitalism. He was judged to find some of these aspects potentially revolutionary in themes such as sensibility, esthetics, social movements and in the radical transformations of his own necessities and aspirations.
Keywords: Performance principle. Qualitative change. Instinctive rehabilitation.
Data de registro:13/06/2012
Data de aceite:28/01/2013
Optimizing Artificial Intelligence Systems for Real-World Applications
Authors: Boya Marqas Ridwan , Saman M. Almufty  , ENGİN AVCI Prof. Dr. , R. Asaad Renas
Published: February 2025

The optimization of Artificial Intelligence (AI) systems is critical for improving performance, scalability, and adaptability across various real-world applications. This paper explores key optimization techniques, including algorithmic enhancements, hardware acceleration, software tools, and data preprocessing. Challenges such as resource constraints, domain-specific requirements, and ethical concerns are analyzed. Case studies in healthcare, finance, manufacturing, and autonomous systems demonstrate notable improvements in accuracy, efficiency, and scalability. A systematic framework is proposed to guide AI optimization, incorporating iterative testing, hardware-software integration, and deployment strategies. The findings highlight AI optimization’s transformative potential in developing scalable, efficient, and ethical systems. Future research directions include the creation of generalizable frameworks, energy-efficient AI, and fairness-aware optimization to ensure broader applicability and equity.
Strategy and tactics for the development of production of healthy food products using medicinal plant raw materials
Authors:   Orel State Agricultural University named after N.V. Parakhina, Evdokimov Nikita , Evdokimova Oksana ,   Orel State Agricultural University named after N.V. Parakhina, Ivanova Tamara ,   Orel State University named after I.S. Turgeneva
Published: February 2025

There is a problem of micronutrient deficiency; in addition, it has been established that the main problems of nutritional balance are associated with the excess of the calorie content of the diet over the level of energy consumption, excess fat and sugar content, and excess consumption of table salt in industrially produced products. There is a sufficient legislative and regulatory framework for individual industries regarding the provision of the population with dietary food products; a deficiency of vitamin D and A, B vitamins, and polyhypovitaminosis conditions of the adult population have been established, which requires the enrichment of industrial production to improve the vitamin status of the population. Today, the need for vitamins and minerals is partially met through imports, however, the lack of domestic production of substances of individual vitamins poses a threat to the food security of the state; an alternative to imports can be the production of domestic food additives and functional food products using medicinal plant raw materials rich in biologically active substances. A list of federal laws and orders is provided, which indicate the powers of individual bodies of the constituent entities of the Russian Federation. However, there is no mechanism for interaction between stakeholders. A strategy for the development of three industries at the regional level is proposed: Forestry departments, aimed at improving the system of drug procurement, healthcare – at identifying and preventing non-communicable diseases, industry – at organizing and introducing innovative food products into production at enterprises of the constituent entities of the Russian Federation, trade – at organizing the sale of dietary products. Mechanisms of interaction and development tactics aimed at creating a healthy nutrition system are proposed for each Department.
A bridge between convexity and quasiconvexity
Authors: Blanc Pablo , Parviainen Mikko , Rossi Julio D.
Published: February 2025

We introduce a notion of convexity with respect to a one-dimensional operator
and with this notion find
a one-parameter family of different convexities that interpolates between
classical convexity and quasiconvexity.
We show that, for this interpolation family, the convex envelope of a continuous boundary datum in a strictly convex domain
is continuous up to the boundary and is characterized as being the unique viscosity solution to the
Dirichlet problem in the domain for
a certain fully nonlinear partial differential equation that involves the associated operator.
In addition we prove that the convex envelopes of a boundary datum constitute a one-parameter curve of functions that goes from the quasiconvex envelope to the convex envelope being continuous with respect to uniform convergence.
Finally, we also
show some regularity results for the convex envelopes proving that there is
an analogous to a supporting hyperplane at every point and that convex envelopes are

C
1

{C^{1}}

if the boundary data satisfies in particular NV-condition we introduce.
Deep learning in metallography: adapting a grain size determination model to develop the new comparison charts for ISO 643
Authors: Wu Z. , Li J. , Zhang J. , Stücklin S.
Published: February 2025

The determination of average grain size is an important component in the microstructural characterization of metallic materials. The grain size is usually determined using the intercept and comparison methods, but there are problems with the relatively time-consuming intercept method and the low accuracy of the comparison method. In this paper, a new model is proposed to realize the task of automatic grain size grading using a combination of traditional image processing and deep learning. Deep learning semantic segmentation and image classification are used to achieve the grading of different quality images. The model is capable of extracting and complementing grain boundaries and calculating the pixel area of the grains. The accuracy of the model was tested on metallographic phases of pure iron and austenitic stainless steel. Using this model, grain size comparison charts were produced for ISO 643 based on real metallographic photographs.
Flexural Strength and Failure Behavior of Glass Laminate Aluminum Reinforced Epoxy and Aluminum-Lithium Laminates in Abrasive Water Jet Peening Under Contamination
Authors: Qutaba Syed , Sandy Galang , Ahmed Sajjad , Azhari Azmir
Published: February 2025

Abrasive Waterjet Peening (AWJP) technology has been widely utilized for various machining, surface treatment, and material indentation applications. The goal of this study is to investigate the influence of AWJP parameters (stand-off distance, water pressure, abrasive size, and number of passes) on the bending strength and types of damage during the peening process of the Fiber Metal Laminates (FML). The surface treatment with AWJP has resulted in variant effects on the surface of the FML. Furthermore, the effect of FML structure with spreading layers was investigated for deformation during the AWJP process. Analysis of variance (ANOVA) was used in the present study to evaluate the effect of AWJP parameters on the failure behavior of 3/2 aluminum-lithium alloy and glass fiber laminate. Results indicated that the fiber layers hindered the deformation of the aluminum-lithium layer. Moreover, the layup of fiber layers and the abrasive size affected the craters’ shape on the metallic surface of aluminum-lithium layers. In terms of four parameters, it was found that the medium level of parameters was sufficient based on ANOVA, which showed a higher flexural strength (up to 482 MPa). Based on the results related to flexural strength, the residual stress field of the FMLs under multiple passes indentation was simulated as the higher flexural strength. The prediction and actual values were consistent with the experimental results, with the overall increase being ± 10%. “Effect” A morphology study revealed that “FML flexural strength deteriorated and caused damage due to the high impact intensity of peening with increases in the craters effect.” Hence, resistance is effective at low impact due to the high craters effect.
Evaluación de la calidad del agua para consumo bovino en Santa Fe, Argentina
Authors: Boglione Rosana , Griffa Carina , Schierano María Celeste , Asforno Melina , Gutiérrez Gonzalo , Farías Marisol
Published: February 2025

[Introduction]: Water is essential for all living beings as it facilitates nutrient transfer, waste elimination, and body temperature regulation. Groundwater is the primary source for bovine livestock consumption, and poor-quality water can negatively affect their health, reproduction, and productivity. In Argentina, bovine farming for meat and milk production is a significant economic activity, making it crucial to ensure an adequate supply of water in both quantity and quality. [Objective]: This study aims to evaluate groundwater quality for cattle in the Santa Fe dairy basin, Argentina, using a water quality index adapted for bovines. [Methodology]: During the 2023-2024 period, groundwater samples were collected from one of the main dairy basins in the country. Parameters significant to water quality for bovine consumption, such as pH, Total Dissolved Solids, Sulfate, Chloride, Nitrate, and Arsenic, were analyzed at each monitored well. Each parameter was assigned a score based on its harmful effects on livestock, and a mathematical equation was applied to classify water quality from very good to extremely poor. [Results]: The study revealed that a high percentage of samples in the dairy basin are of good or very good quality, although wells with poor water quality were also identified. [Conclusions]: The findings highlight the importance of monitoring and managing groundwater quality to ensure sustainable bovine farming in the Santa Fe dairy basin.
Application of Next-Generation Sequencing to Realize Principles of Precision Therapy in Management of Cancer Patients
Authors: KHRANOVSKA N. , GORBACH O. , SKACHKOVA O. , KLIMNYUK G.
Published: February 2025

All cancers are diseases of the genome, since the cancer cell genome typically consists of 10,000s of passenger alterations, 5—10 biologically relevant alterations, and 1—2 “actionable” alterations. Therefore, somatic mutations in cancer cells can have diagnostic, prognostic, and predictive value. Traditional methods are widely used for testing, such as immunohistochemistry, Sanger sequencing, and allele-specific PCR. However, due to the low throughput, these methods are focused exclusively on testing the most common mutations in target genes. The modern next generation sequencing (NGS) is a technology that enables precision oncology in its current form. ESCAT and ESMO Guidelines defined NGS for routine use in patients with advanced cancers such as non-squamous non-small cell lung cancer, prostate cancer, ovarian cancer, and cholangiocarcinoma. The high sensitivity of the NGS method allows it to be used to search for specific mutations in circulating tumor DNA in blood plasma and other body fluids. NGS testing has evolved from hotspot panels, actionable gene panels, and disease-specific panels to more comprehensive panels. The exome and whole genome sequencing approaches are just beginning to emerge, that is why panel-based testing remains most optimal in oncology practice. NGS is also widely used to identify new and rare mutations in cancer genes and detect inherited cancer mutations.
PD-L1 Expression in Receptor-Negative Breast Cancer Tissue
Authors: LUKIANOV Ye. A , MUSHII O. , KROTEVYCH M. , ZADVORNYI T.
Published: February 2025

Background. The high heterogeneity and pathogenetic diversity of breast cancer (BCa) indicate the need for further study of tumor cell biology in order to identify molecular biological markers associated with the aggressiveness of tumors with a negative receptor status. Among many factors that may be involved in the initiation and progression of this form of cancer, the study of the immune components of tumor microenvironment, in particular PD-L1, is considered promising. Aim. To investigate the relationship between PD-L1 expression in tumor tissue and clinical and pathological characteristics of BCa, taking into account the status of steroid hormone receptors. Materials and Methods. In tumor tissue of 116 patients with stage I—II BCa, the mRNA levels of CD274 gene were determined using the real-time quantitative polymerase chain reaction. The expression of PD-L1 was studied by the immunohistochemical method. Results. The tissue of receptor-negative BCa was characterized by a significant decrease in the CD274 mRNA level against the background of the increased PD-L1 expression compared to neoplasms positive for the expression of steroid hormone receptors. An inverse correlation was found between PD-L1 at the protein level and the age of patients with receptor-negative BCa (r = –0.613, p = 0.00003). We showed that a characteristic feature of receptor-negative BCa in menopausal patients is the increased expression of PD-L1 both at the protein and mRNA levels (p = 0.005 and p = 0.046, respectively). The correlation of PD-L1 expression with metastatic lesions in regional lymph nodes (p = 0.050), tumor differentiation grade (p = 0.001), and the patient survival rate was revealed. Conclusions. The obtained data indicated the expediency of using PD-L1 expression indicators for in-depth characterization of the tumor microenvironment of receptor-negative BCa, which will allow for the personalized correction of therapy regimens contributing to the improvement of the patients' quality of life.
On the problem of object recognition on devices with limited resources
Authors:   NTUU "KPI", Berdnyk Y.M. , Skotarenko A.O. ,   NTUU "KPI"
Published: February 2025

The problem of implementing object recognition on microcontrollers with limited resources, particularly the challenges related to their computational power, memory capacity, and energy consumption is addressesed. The use of the compact MobileNet neural network architecture is proposed, which is based on an algorithm with reduced computational load and ensures sufficient performance in resource-constrained environments. This approach enables image classification tasks to be performed on low-cost microcontrollers. Although the technologies discussed are well-known individually, their comprehensive application for specific classification tasks on microcontrollers, such as object recognition, remains underexplored. The article provides a detailed description of all development stages, including data preparation, model parameter tuning, and the use of specialized image scaling methods to reduce computational load. The practical part of the article is devoted to developing a strawberry recognition system to determine their ripeness level using the ESP32 microcontroller. The research results demonstrate the effectiveness of the approach for different applied tasks and confirm the feasibility of integrating computer vision technologies into resource-limited devices. Overall, the work proves that modern machine learning technologies are becoming accessible even to the least powerful hardware platforms, expanding their capabilities and areas of application.
Software solution for electrocardiogram storage and analysis
Authors:   Kiev Taras Shevchenko National University, Yefremov M.S. , Krak Yu.V. ,   Kiev Taras Shevchenko National University
Published: February 2025

Software solutions for medical and healthcare fields are becoming increasingly popular due to advancements in information technology. Over the past decades peak detection algorithms as well as detection of other segments on ECG, arrhythmias detection and other pathologies detection algorithms achieved significant accuracy. This study proposes an approach for integrating such algorithms into a unified systems by developing a software solution that analyzes available ECGs from various sources, standardizes them into a common format, and provides detailed reporting that is easily understandable for medical experts or patients. The implementation is carried out as a web application that can provide users with information about cardiograms, process ECGs depending on the integrated algorithms, store necessary ECG segments, diagnostic results, and more. The system incorporates a newly developed algorithm for detecting R-peaks and visualizing ECG signals processed by the algorithm with annotations obtained both automatically and with the participation of cardiology specialists.
Opieka nad dziećmi na ziemiach polskich w XIX‒XXI wieku. Słownik historyczny
Authors: Chylak Karol ,   Uniwersytet Łódzki, Haligowska Aleksandra ,   Muzeum Okręgowe w Rzeszowie, Jaroszyk Joanna ,   Uniwersytet im. Adama Mickiewicza w Poznaniu, Merta-Staszczak Adriana ,   Politechnika Wrocławska, Niezgoda Monika Niezgoda ,   Uniwersytet Rzeszowski, Pasterski Bartosz ,   Uniwersytet Rzeszowski
Published: February 2025

Oddawany do rąk czytelników słownik historyczny Opieka nad dziećmi na ziemiach polskich w XIX‒XXI wieku jest głównym efektem realizacji projektu „Ku lepszej przyszłości. Opieka nad dziećmi na ziemiach polskich w XIX‒XXI wieku” finansowanego w ramach programu Ministerstwa Edukacji i Nauki „Nauka dla Społeczeństwa” i nastawionego na badania nad dziejami opieki nad dzieckiem na ziemiach polskich od XIX do XXI wieku. Opieka ta rozumiana jest maksymalnie szeroko i obejmuje w przyjętym znaczeniu wiele aspektów działań na rzecz dzieci zarówno w środowisku rodzinnym, jak i poprzez wszelkie formy wsparcia oferowane przez instytucje zewnętrzne ‒ od państwa poprzez władze samorządowe, organizacje społeczne aż po związki wyznaniowe ‒ uwzględniając też teoretyczne i prawne podstawy wychowania i opieki nad dziećmi formułowane w okresie będącym przedmiotem prowadzonych dociekań.
Pain management in hospitalized infants: recommendations for achieving the Sustainable Development Goals
Authors: Souza Danton Matheus de , Monteiro Caroline Knoner , Rossato Lisabelle Mariano
Published: February 2025

ABSTRACT Objective: to assess pain management in infants in a Neonatal Intensive Care Unit (NICU) and discuss its articulation with the Sustainable Development Goals, with a focus on promoting neonatal well-being. Method: a documentary study, retrospective in nature and quantitative approach, conducted in a NICU of a public hospital in Paraná, Brazil, between January and July 2022, with 386 medical records of infants, hospitalized for more than 24 hours, between 2019 and 2021. Data were subjected to descriptive and inferential analysis, considering p-value<0.05 as a statistical difference. National ethical guidelines were respected. Results: all infants underwent at least one painful procedure, but only 13.7% had documented pain. Pharmacological interventions, such as fentanyl (25.9%), and non-pharmacological interventions, such as breastfeeding encouragement (86%) were used. Only 2.8% were reassessed. Conclusion: there was a devaluation of neonatal pain management that may perpetuate neonatal well-being and sustainable development.
Nursing students and the internet: a reflection of digital ethics
Authors: Brandão Ana Carolina Barboza , Ramos Ingrid Bemfica , Oliveira Anna Carolina Caetano Griesang de , Duarte Sabrina da Costa Machado , Tavares Joyce Martins Arimatea Branco , Broca Priscilla Valladares
Published: February 2025

ABSTRACT Objectives: to identify how first-year nursing students use cyberspace and propose an orientation guide with criteria guiding the use of cyberspace. Methods: qualitative and descriptive research, carried out with 24 nursing students from a federal public institution in Rio de Janeiro. Data collection was carried out through semi-structured interviews. Data analysis occurred using IRAMUTEQ®. The research was approved by the institution’s Research Ethics Committee. Results: students use cyberspace to communicate, study, find “cool things”, share photos and memories. Furthermore, they are concerned about hate speech, intolerance and fake news. The good and bad sides and the types of technologies most used were also portrayed. Final considerations: the moral and ethical values of physical coexistence, together with awareness of individual responsibility, are the pillars for using cyberspace. The guide comes as an awareness tool.
Social Representations of pregnancy among trans men
Authors: Pereira Danilo Martins Roque , Araújo Ednaldo Cavalcante de , Oliveira Sheyla Costa de , Sousa Anderson Reis de , Espíndola Mariana Mercês Mesquita , West Milka Gabrielle de Lira Nóbrega , Ramalho Marclineide Nóbrega de Andrade , Cardoso Joecio Cordeiro
Published: February 2025

ABSTRACT Objective: to understand the meanings and experiences of pregnancy among trans men in light of the Theory of Social Representations. Methods: this is a qualitative, descriptive and exploratory study, carried out with trans men selected for convenience and availability. Data production took place from September to October 2021, via the Google Meet® platform, based on interviews with a semi-structured script. Interview lexicographic textual analysis was performed using the Reinert method and instrumented by IRAMUTEQ version 7.0. Results: social representations of pregnancy involved a wide field of meanings, in which efforts were articulated to accept opportune and solitary pregnancy, fear of the parturition process and influence of physical and emotional changes. Final considerations: the study reinforces the importance of advanced nursing practice in assisting the pregnancy-puerperal cycle, based on the perspective of comprehensive care, equity in access to services and respect for differences.
Sustentabilidade no Ensino Superior: Relato de experiência sobre o cumprimento dos Objetivos de Desenvolvimento Sustentável
Authors: Lopes Laura Mafalda Carvalho , Matias-Correia Rosalina , Silva Rosa Carla Gomes da , Machado Natália de Jesus Barbosa , França Ana Paula dos Santos Jesus Marques
Published: February 2025

RESUMO Objetivo: Descrever as atividades que visam o cumprimento dos Objetivos de Desenvolvimento Sustentável (ODS), implementadas por uma instituição de ensino superior politécnico, da região norte de Portugal. Métodos: Trata-se de um relato de experiência de uma Instituição de Ensino Superior, que caracteriza o contributo para os ODS, no âmbito do ensino, investigação, campus e liderança. Resultados: No total, foram mapeadas 1247 atividades, com uma preponderância na dimensão “pessoas” (685 atividades), sendo o ODS 3 o mais destacado. Os artigos científicos contribuem de forma significativa para os ODS, com uma discrepância notável entre as classificações automáticas (Scopus) e manuais, indicando uma tendência de subestimação do impacto dos estudos de enfermagem. Conclusão: Os resultados demostram a contribuição significativa desta instituição para os ODS, com um foco especial na saúde e educação. Esta contribuição reflete a missão da instituição que passa por formar profissionais de saúde competentes e socialmente conscientes, mas simultaneamente a necessidade de maior sensibilização e formação do corpo docente.
Self-harm in the two years of greatest restrictions during the covid-19 pandemic: a cross-sectional study
Authors: Santos Odilon Vieira , Silva Letícia Aparecida Machado Lisboa da , Okuno Meiry Fernanda Pinto , Hino Paula , Martínez-Riera José Ramón , Fernandes Hugo
Published: February 2025

ABSTRACT Objective: to analyze occurrence of self-harm, sociodemographic profile of victims and referrals in the first 24 months of the COVID-19 pandemic in São Paulo. Method: cross-sectional study carried out by the Notifiable Diseases Information System with data on self-harm in São Paulo. The period outlined was March 2020 to February 2022. R (4.0.2) software and chi-square test were used. Results: there were 15,946 incidents. Victims were young, white, single, heterosexual women. There was high incidence of people with previous mental disorders more than once and without clear motivation. The method used was poisoning/intoxication. There was a considerable number of referrals to the health network, although not totalitarian. Conclusion: the years of greater insecurity in relation to the pandemic have given rise to self-harm cases with peculiar characteristics. Agile health policies must be applied in atypical conditions, such as pandemics, especially for adolescents/young people with previous mental disorders.
Violência autoprovocada nos dois anos de maior restrição da pandemia de covid-19: estudo transversal
Authors: Santos Odilon Vieira , Silva Letícia Aparecida Machado Lisboa da , Okuno Meiry Fernanda Pinto , Hino Paula , Martínez-Riera José Ramón , Fernandes Hugo
Published: February 2025

Resumo Objetivo: analisar a ocorrência de violência autoprovocada, o perfil sociodemográfico das vítimas e os encaminhamentos nos primeiros 24 meses da pandemia de COVID-19 em São Paulo. Método: estudo transversal, realizado pelo Sistema de Informação de Agravos de Notificação com dados de violência autoprovocada em São Paulo. O período delineado foi março de 2020 a fevereiro de 2022. Utilizaram-se o software R (4.0.2) e teste qui-quadrado. Resultados: ocorreram 15.946 ocorrências. As vítimas foram mulheres, jovens, brancas, solteiras e heterossexuais. Houve elevada ocorrência em pessoas com transtornos mentais prévios mais de uma vez e sem motivação clara. O meio utilizado foi o envenenamento/intoxicação. Houve número considerável de encaminhamentos à rede de saúde, porém não totalitário. Conclusão: os anos de maior insegurança em relação à pandemia suscitaram casos de violência autoprovocada com características peculiares. Políticas de saúde ágeis devem ser aplicadas em condições atípicas, como pandemias, especialmente para adolescentes/jovens com transtornos mentais prévios.
A Guerra de Sessenta Anos: A região-mundo platina e as causas do conflito de 1864
Authors: GOYENA SOARES RODRIGO
Published: February 2025

RESUMO O artigo propõe o enquadramento teórico-metodológico da região-mundo no intuito de reler os porquês do conflito de 1864. Argumenta-se que a perspectiva das alianças sistêmicas - o estado historiográfico da arte - assume, talvez insuficientemente, a dimensão temporal que caracteriza a região-mundo. Nesta proposta, o conflito de 1864 não decorreu apenas de um entorno geopolítico conflitivo, mas sobretudo da incorporação do passado na redefinição de interesses nacionais. Para além da unidade espacial ou da inserção na economia-mundo polarizada pela Grã-Bretanha, o Prata foi uma região-mundo demarcada no Oitocentos principalmente por dois estratos de tempo. O primeiro, que se desenrolou até meados do século XIX, distinguiu-se pela formação disputada dos Estados-nacionais e resolveu-se com a hegemonização regional do Brasil. As contradições subsequentes, próprias a um segundo estrato desdobrado até 1870, retrataram as ameaças ao novo status quo, isto é, a unipolaridade brasileira. Assim, o conflito de 1864 - no fundo, apenas um episódio da Guerra de Sessenta Anos - foi mais originário do tempo platino reconfigurado em 1851-1852 do que das alianças de 1863-1864, elas mesmas apenas expressões do segundo estrato de tempo, qualificado por Estados-nacionais já consolidados.
ANTECEDENTES DO APRENDIZADO A PARTIR DO ERRO NO LOCAL DE TRABALHO
Authors: Sbrissa Elaine Cristina da Costa Carreira , Bido Diógenes de Souza , Vieira Almir Martins
Published: February 2025

RESUMO O objetivo deste trabalho é propor e testar um modelo do aprendizado a partir do erro (APE) e seus antecedentes, relacionando os constructos liderança inclusiva, segurança psicológica, contexto de apoio e autoeficácia na perspectiva individual, dentro do ambiente organizacional. Adotou-se a abordagem quantitativa, com uma amostra de 242 indivíduos que atuam em organizações e que possuem superiores. A análise dos dados foi feita por meio da modelagem de equações estruturais. Os resultados indicaram relações positivas entre a liderança inclusiva e a autoeficácia com o APE, como também entre o contexto de apoio e a segurança psicológica. A relação da segurança psicológica com o APE e o efeito moderador da autoeficácia não foram confirmados. Uma explicação para esse resultado foi a alta pontuação dessa amostra na escala de APE (mediana no topo da escala), que resultou em baixa variabilidade. Por isso, para futuras pesquisas, sugere-se especificar com maior detalhamento quais tipos de erros devem ser considerados (erros mais graves), o que pode diminuir a pontuação do APE, aumentar sua variabilidade e o poder preditivo de seus antecedentes.
COMO FICA A SAÚDE FÍSICA E MENTAL? UMA PESQUISA COM ESTUDANTES QUE CONCILIAM TRABALHO E MESTRADO ACADÊMICO
Authors: Soares Edilene Darley , Campos Alyce Cardoso , Souza Caissa Veloso e , Oliveira Alyne Luysa Rodrigues Duarte
Published: February 2025

RESUMO Este estudo teve como objetivo compreender como a conciliação entre trabalho e estudo pode impactar na saúde física e mental de alunos de mestrado acadêmico. Dados do Ministério da Educação (MEC) revelam aumento significativo no número de mestrandos e doutorandos no Brasil, que em 2021 era de 322.969, alcançando a margem de 350 mil matriculados em 2023. Embora alcançar o título de mestre ou doutor seja um marco acadêmico, a jornada desses estudantes é permeada por desafios devido às particularidades do ambiente de pós-graduação em nível stricto sensu, demarcado por nuances de exigências mais elevadas. Essas exigências são impostas a estudantes que lidam com situações complexas de vida, o que pode gerar impactos significativos na saúde geral. Esta foi uma pesquisa de abordagem qualitativa/descritiva, realizada por entrevistas semiestruturadas conduzidas com 14 estudantes que conciliam trabalho e mestrado acadêmico em instituições localizadas em Minas Gerais. Nos resultados produzidos pela pesquisa, os participantes relataram que vivenciam altos níveis de esgotamento e sofrimento psicológico, o que gera cansaço, fadiga, exaustão e outros, provocados pelo estresse da rotina exaustiva e pelas cobranças elevadas. Concluiu-se a pesquisa identificando necessidade de manejo no apoio clínico-psíquico para estudantes de mestrado e doutorado no Brasil.
CRIAÇÃO DE MINI BUSINESS INTELLIGENCE PARA REESTRUTURAÇÃO CURRICULAR EM INSTITUIÇÃO FEDERAL NO PÓS-COVID-19
Authors: Paraiso Rita Maria , Siqueira Gissélida do Prado , Valerio Victor Eduardo de Mello , Garcia Dionatas Alex
Published: February 2025

RESUMO O retorno das aulas presenciais, em 2022, após a pandemia da covid-19, configurou um desafio para as instituições de ensino na formulação de planos para reduzir os impactos na vida acadêmica. Assim, buscou-se uma alternativa adotando sistemas de informação para o desenvolvimento de estratégias na gestão de dados educacionais. O objetivo da pesquisa foi a criação de um mini BI (Business Intelligence) para auxiliar na programação das turmas do Instituto Federal Sul de Minas Gerais – campus Muzambinho. A metodologia empregada foi a CRISP-DM (Cross Industry Standard Process for Data Mining), composta de seis etapas realizadas em dois ciclos, permitindo entregar aos gestores tabelas e dashboards para programar turmas com o mesmo quantitativo de docentes, munindo os coordenadores com dados sobre o número de estudantes e o tipo de turma. A solução contribuiu para uma tomada de decisão mais rápida e assertiva na oferta de disciplinas em 2022. Além disso, o estudo oferece um modelo replicável, que pode ser aplicado por outras instituições que enfrentam desafios semelhantes, otimizando a programação de turmas e melhorando a eficiência e a qualidade acadêmica.
Alpinia zerumbet leaf extract reverses hypertension and improves adverse remodeling in the left ventricle and aorta in spontaneously hypertensive rats
Authors: Menezes M.P. , Santos G.P. , Nunes D.V.Q. , Silva D.L.B. , Victório C.P. , Fernandes-Santos C. , Bem G.F. de , Costa C.A. , Resende A.C. , Ognibene D.T.
Published: February 2025

Alpinia zerumbet, a plant native to East Asia, is widely found on the Brazilian coast, where it is used in folk medicine as an antihypertensive, diuretic, and anxiolytic. This study investigated the effects of the hydroalcoholic extract obtained from Alpinia zerumbet leaves (AZE) on cardiovascular changes and oxidative status in spontaneously hypertensive rats (SHR). SHR and Wistar-Kyoto male rats, 90 days old, treated or not with AZE (50 mg/kg/day in drinking water) for six weeks, were used in this study. Blood pressure (BP) was assessed weekly by tail plethysmography. At the end of treatment, the animals were anesthetized with thiopental (70 mg/kg, ip), blood was collected through abdominal aorta puncture, the thoracic aorta and left ventricle were isolated for morphometric analysis and immunostaining of NOX-4, SOD-2, 8-isoprostane, and angiotensin II AT1 receptors (AT1R), and the mesenteric arterial bed (MAB) was isolated for the assessment of vascular function. Oxidative damage in lipids and proteins and the enzymatic antioxidant activity were evaluated in plasma samples by spectrophotometry. AZE normalized BP in SHR. Although the treatment did not improve the MAB vascular dysfunction, it reversed the cardiovascular remodeling in the aorta and left ventricle. In addition, AZE improved antioxidant activity in plasma and SOD-2 immunostaining in the thoracic aorta and left ventricle, decreased protein carbonylation in plasma, and reduced 8-isoprostane, NOX-4, and AT1R immunostaining in the cardiovascular system. The results suggested that AZE reversed hypertension and cardiovascular remodeling in SHR, which was associated with lower oxidative stress and AT1R.