bluuebunny/crossref_metadata_2025 huggingface dataset:
DESIGN, SYNTHESIS AND PSYCHOPHARMACOLOGICAL ACTIVITY OF QUINOLIN-2-ONE DERIVATIVES
Authors: Emmie de Abreu , Chandavarkar S. K , Biradar B. S , S. S. Bobde , Naik S. P. , Mamledesai S. N. ,   Department of Pharmaceutical Chemistry, PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda - 403 401, Goa, India
Published: January 2022

Starting material 4-hydroxy-1-phenyl/methyl-quinolin-2-(1H)-one was treated with phosphorous oxychloride and then subjected to Mannich reaction to yield title 4-chloro-1-phenyl/methyl-3-[3- (substituted) propanoyl] quinolin-2(1H)-one derivatives compounds IIa (1-7)/ IIb (1-7). Molecular docking studies of the compounds were carried out using Molegro Virtual Docker. All the synthesized compounds were characterized by IR, 1H-NMR and Mass Spectral data and were tested for their antidepressant activity. Amongst the synthesized compounds, compound 4-chloro-1-phenyl-3-[3-(morpholinopropanoyl] quinolin-2(1H)-one [IIa4] was found to show the most potent antidepressant activity with immobility time of 98.17± 4.806. Compound 4-chloro-1-phenyl-3-[3-(4- methylpiperazin-1-yl) propanoyl] quinolin-2(1H)- one [IIa 3] and 4-chloro-1-methyl-3-[3-(pyrrolidin-1-yl) propanoyl] quinolin-2(1H)-one [IIb 2] showed moderate antidepressant activity with immobility time of 126.5 ± 1.945s and 120.3 ± 2.376s, respectively, compared to standard imipramine.
DISRUPTIVE INNOVATION AT THE INTERFACES OF THE DRUG INDUSTRY
Authors:   Head, NCL Innovations & Director, Venture Center CSIR-National Chemical Laboratory, Pune, Premnath V.
Published: January 2022

Dear Reader, I am delighted to contribute this Guest Editorial for the current issue of Indian Drugs. I was very happy to interact with industry leaders at the Indian Drugs Annual Day 2019 and share some of our learnings on innovation and entrepreneurship in medical products. In this Guest Editorial, I wish to focus on how innovation at the interface of the drug industry and other industries serving the healthcare market will shape the drug industry in the future.
Completely monotone sequences and harmonic mappings
Authors: Long Bo-Yong , Sugawa Toshiyuki , Wang Qi-Han
Published: January 2022

In the present paper, we will study geometric properties of harmonic mappings whose analytic and co-analytic parts are (shifted) generated functions of completely monotone sequences.
On logarithmic Hölder continuity of mappings on the boundary
Authors: Sevost'yanov Evgeny
Published: January 2022

We study mappings satisfying the so-called inverse Poletsky inequality. Under integrability of the corresponding majorant, it is proved that these mappings are logarithmic Hölder continuous in the neighborhood of the boundary points. In particular, the indicated properties hold for homeomorphisms whose inverse satisfy the weighted Poletsky inequality.
Budaya dan Identitas Nasional dalam Alih Manajemen Sumber Daya Manusia pada Perusahaan Multinasional
Authors: Dasmadi Dasmadi
Published: January 2022

Setiap negara pasti memiliki budaya nasional yang memberikan panduan kultural bagaimana kecenderungan karakter warga negaranya terbentuk. Disisi lain, dunia bisnis global memungkinkan korporasi dunia atau sering disebut perusahaan multinasional (MNC) melakukan investasi pada negara – negara menanam investasi dengan mendirikan anak perusahaan atau cabangnya di berbagai negara. Tulisan ini akan mengkaji tentang peran budaya nasional suatu negara dalam mengalihka pengelolaan Sumber Daya Manusia (SDM) dari sentral Perusahaan Multinasional (MNC) ke cabang – cabang atau anak perusahaannya di berbagai negara. Artikel ini merupakan studi pustaka pendekatan kualitatif dengan metode deskriptif yaitu dengan cara mengumpulkan, menganalisis, dan membuat gambaran segala kondisi - situasi dari data yang telah  terkumpul. Data – data diambil dari berbagai sumber seperti buku, jurnal,dan lainnya. Analisis data dilakukan dengan reduksi data, yang selanjutnya dianalisis berdasarkan teori teori yang dipilih dalam penelitian ini dan disajikan dalam bentuk narasi ilmiah. Hasil penelitian menunjukkan bahwa budaya organisasi yang berlaku di anak perusahaan bisa berbeda dari satu negara ke negara di mana mereka beroperasi. Selanjutnya dapat disimpulkan bahwa praktik pengelolaan ketenagakerjaan dapat dialihkan pada perusahaan multinasional (MNC) akan sangat tergantung pada budaya nasional negara tersebut. Alih pola pengelolaan SDM ini umumnya dimediasi oleh budaya organisasi (yang dipengaruhi budaya lokal/setempat) yang berlaku di anak perusahaan.
Two-way Evaluation and Analysis of Student-centered Pharmacy Teaching
Authors: Cheng Lijuan
Published: January 2022

Student-centered teaching model is a very important concept in the education sector, which will be restricted and influenced by many factors in the process of implementation. This paper focuses on investigating and studying the influence of teachers, students and supporting management of teaching reform on this teaching mode. According to undergraduates in pharmacy department of our hospital, the whole class was divided into study group and control group. Two-way evaluation method was used in the study group, and traditional experimental teaching method was used in the control group. The experimental theory, skill test scores and experimental report scores of the two groups of students were compared and analyzed, and the evaluation of teachers' teaching methods and learning effects of the students in the study group were investigated. The results show that students' evaluation of the Two-way evaluation method and teaching effect are very good. Two-way evaluation can stimulate students' interest in learning, and help to cultivate students' awareness of inquiry, practical ability, innovative ability, ability to analyze and solve problems.
Discussion on the Construction of Campus Culture in the Environment of New Media based on Computer Network
Authors: Ning Kai
Published: January 2022

In the computer network and new media environment, continuously strengthening the construction of campus culture in our country has a very important role and significance. It can not only promote the healthy development of students' thoughts and behaviors, but also enable them to complete the learning of relevant subjects and professional knowledge in a more convenient and efficient learning environment. This article first understands the current situation, connotation and significance of campus culture construction in our country under the computer network new media environment, and then further analyzes the main problems faced by our country’s campus culture construction under the computer network new media environment, and finally discusses further in this environment. The main methods and strategies to strengthen the construction of campus culture in our country.
Analysis on the Dilemma Development Strategies of Higher Vocational Education in China
Authors: Yang Yi
Published: January 2022

The state council meeting strongly supports the establishment of vocational schools and promotes the integration and mutual recognition of academic results between vocational education and general education. By analyzing the dilemmas and problems in the development of higher vocational schools in China, it is found that higher vocational education has long been in an awkward situation. On one hand is to provide the supply of talents for enterprises, on the other hand is to break the obstacles in the development of higher vocational schools. To put vocational schools play active role in educational field and job market is the key objective of this study.
D. Perhitungan HPP Telur Asin Dengan Pendekatan Variabel Costing Pada UD Mulya Jaya
Authors: Pratiwi Neno , Setiawan Andre , Cayono Ilmi , Trinanto Johan
Published: January 2022

ABSTRAK

Pada umumnya harga pokok produksi dalam akuntansi diartikan dengan jumlah biaya dari seluruh pemakaian yang telah dilakukan selama proses produksi atau kegiatan yang mana mengubah bahan baku menjadi produk jadi (produk siap pakai/siap saji). Tujuan penting dalam tugas ini yaitu memperhitungkan harga pokok produksi dari UD Mulya Jaya dengan menggunakan pendekatan variabel costing untuk mengetahui besarnya harga pokok pada setiap produk yang diproduksi. Pentingnya penentuan harga pokok produksi dapat dilakukan sebelum para usaha menentukan harga jual. Pendampingan ini bertujuan untuk membantu mencari dan menentukan harga pokok produksi yang dapat digunakan untuk menetapkan harga jual. Pendampingan ini dilakukan untuk membantu wirausaha dalam program kerja, yaitu bimbingan akuntansi dengan fokus perhitungan harga pokok produksi. Dalam menentukan harga pokok produksi pada UD Mulya Jaya dapat menggunakan pendekatan variable costing yang biasanya metode ini digunakan untuk semacam pengambilan keputusan dalam perusahaan. Melalui program pendampingan kewirausahaan didapatkan hasil perhitungan harga pokok produksi yang menggunakan pendekatan variabel costing. Hasil tersebut dapat menjadi suatu keputusan bagi UD Mulya Jaya untuk dapat menetapkan harga pokok produksi pada setiap produk telur asin.

Kata Kunci : Kewirausahaan, HPP, Harga.

 

ABSTRACT

In general, the cost of production in accounting is defined as the total cost of all uses that have been made during the production process or activities which convert raw materials into finished products (ready-to-use / ready-to-serve products). An important objective in this task is to calculate the cost of goods manufactured from UD Mulya Jaya by using a variable costing approach to find out the cost of goods on each product produced. The importance of determining the cost of production can be done before businesses determine the selling price. This assistance aims to help find and determine the cost of production that can be used to set the selling price. This assistance is carried out to help entrepreneurs in work programs, namely accounting guidance with a focus on calculating the cost of production. In determining the cost of production at UD Mulya Jaya, it can use the variable costing approach, which is usually used for a kind of decision making in a company. Through the entrepreneurship assistance program, the results of the calculation of the cost of production are obtained using the variable costing approach. These results can be a decision for UD Mulya Jaya to be able to set the cost of production for each salted egg product.

Keywords: Entrepreneurship, COGS, Price
D. PENGELOLAAN-DANA-BANTUAN-OPERASIONAL-SEKOLAH-(BOS) PADA-SEKOLAH SWASTA
Authors: Rismanda Alta Surya , Subandoro Agus
Published: January 2022

Abstrak

Penelitian.ini.bertujuan buat menggambarkan pengelolaan.Bantuan.Operasional.Sekolah (BOS) sekolah Swasta pada Sekolah Menengah pertama Islam Randegan termasuk perencanaan, aplikasi, supervisi dan penilaian, dan pelaporan acara BOS..Penelitian ini memakai pendekatan kualitatif menggunakan desain studi masalah. Lokasi penelitian merupakan Sekolah Menengah pertama Islam Randegan Kecamatan Dawarblandong Kabupaten Mojokerto yang terletak pada jalan BKR No 20 Kecamatan Dawarblandong Kabupaten Mojokerto Provinsi Jawa Timur. Sumber.data.penelitian ini merupakan ketua sekolah.  bendahara BOS, komite sekolah, serta orang tua murid yang miskin. Data diperoleh dengan cara wawancara yang mendalam, observasi terhadap partisipan.dan.dokumentasi. Analisis.data.dilakukan ada tiga alur aktivitas seperti  reduksi data. penyajian data, & pembuktian data. Hasil dari analisis data diperoleh kesimpulan bahwa pengelolan dana.Bantuan.Operasional.Sekolah.(BOS) pada Sekolah Menengah pertama Islam Randegan Kecamatan Dawarblandong sudah dilaksanakan sinkron menggunakan prosedur yg tertuang pada pada kitab pedoman BOS yg mencakup unsur perencanaan, aplikasi, supervisi dan penilaian, serta pelaporan dana BOS.

Abstract

This study aims to describe the management of Private School Operational Assistance (BOS) funds at Randegan Islamic Junior High School including planning, application, supervision, and reporting of BOS events. This research uses an approach approach using a problem study design. The research location is Randegan Islamic Junior High School, Dawarblandong District, Mojokerto Regency, which is located on BKR Street No. 20, Dawarblandong District, Mojokerto Regency, East Java Province. The data sources for this research are the school principal, BOS treasurer, school committee, and parents of poor.students. Data.were.obtained.through.in-depth.interviews, participatory observation and documentation. Data analysis was carried out through three activity lines, namely data reduction, data presentation, & data verification. The results of data analysis concluded that the management of School Operational Assistance (BOS) funds at Randegan Islamic Junior High School, Dawarblandong District had been carried out in sync using the oldest procedures in the book. BOS which includes planning, application, guidelines and assessment, as well as reporting on BOS funds
Detection Limit of the Four-Parameter Logistic Model for the Quantitative Detection of Serum Squamous Cell Carcinoma Antigenin Cervical Cancer Based on Surface Plasmon Resonance Biosensor
Authors: Masdor Noor Azlina
Published: January 2022

Biochemical diagnostic procedures, such as protein binding, rely on biomolecular interactions as its diagnostic modality, and as a consequence, their calibration curves are more complex. In addition, sigmoidal curves are often seen in these tests. In the event of asymmetry, a logistic (5PL) curve, or a logistic (4PL) curve, may be the best way to represent a distinctive sigmoidal relationship. It is possible that the linearization of an otherwise nonlinear connection by log transformation may result in a disruption of the error structure of the curve, and that this will have the opposite effect of decreasing or even eliminating error in the relationship. Previously, a surface plasmon resonance biosensor for the detection of squamous cell carcinoma antigen (SCCa) using nanoparticle technology was developed. However, based on the calibration curve, it conforms to the majority on sigmoidal shape curve for antibody-type sensing system. The resultant curve showed a sigmoidal calibration curve but was not modelled according to any of the sigmoidal models available. The LOD value obtained through the 4PL modelling exercise based on the classical method was 0.255 pM (95% confidence interval of 0.167 to 0.379) while the pooled standard deviation (PSD) method yielded an LOD value of 0.035 pM (95% confidence interval of 0.011 to 0.067), which indicates that the PSD method was superior.
An Acrylamide-degrading Bacterial Consortium Isolated from Volcanic Soi
Authors: Rusnam . , Gusmanizar Neni
Published: January 2022

In soil, polyacrylamide is a key source of acrylamide because it slowly decomposes into acrylamide. There has been a modest but steady rise in worldwide interest in microbe-mediated acrylamide decomposition as a bioremediation method. A bacterial consortium isolated from the volcanic soil of Mount Marapi, West Sumatra, Indonesia, was able to thrive on acrylamide in this study. Acrylamide-degrading bacteria grew best in the presence of 1 %(w/v) glucose with acrylamide as the sole nitrogen source. Optimum growth occurs in between 300 and 500 mg/L of acrylamide, pH between 6.5 and 8.0, and temperatures between 30 and 35 °C. The consortium can also grow on acetamide as the sole nitrogen source. Toxic heavy metals, such as mercury, silver and copper slowed down the growth of this consortium on acrylamide. This is the first report of an acrylamide-degrading consortium isolated from volcanic soils.
The Integration of Big Data and Artificial Neural Networks for Enhancing Credit Risk Scoring in Emerging Markets: Evidence from Egypt
Authors: Wagdi Osama , Tarek Yasmeen
Published: January 2022

This study investigates the effectiveness of technology models in credit risk scoring modeling in emerging markets. the study proposes evaluation methods for credit risk scoring modeling for current and potential borrowers through an investigation into the Egyptian banking industry by offering and examining a framework for the integration of big data and artificial neural networks based on systematic and unsystematic risk for both the macroeconomic environment and characteristics of current and potential borrowers. The data for the borrowers under examination covers the period from 2015 to 2019 for 75 firms, excluding 2020 and 2021 data to isolate the impact of COVID-19 on the results of the inferred statistics. Artificial Neural Networks was training within 25 firms under NeuroXL program but examination for 50 firms. The study found the ability of artificial neural networks to rank the commitment of borrowers in Egyptian banks under big data about the firm and Egyptian economy. Additions to discrepancy between the proposed model against some traditional models. Finally; The Integration of Big Data and ANN can help banks to bring out the value of data within create a level of financial stability for banks. Especially in emerging markets characterized by information inefficiency.
Development of Teachers’ Professional Identity as a Second Career in the M.Teach Program as a Lever to Empower the Future Education System
Authors: Simon Eitan
Published: January 2022

The Dovrat Committee (2004) in Israel, pointed up the need for radical change in teacher training programs and recommended introducing school reform programs, such as the New Horizons and the Courage to Change reforms, implemented in the Israeli education system over recent years. The article reviews future teachers’ needs that necessitate changes in the education provided by teacher training colleges. It describes research examining teachers’ professional identity development and desirable characteristics for the future teacher. Participants were 23 student-teachers studying in an M.Teach degree course. The research investigated their attitudes and perceptions concerning the image of the future teacher.
Effects of removable functional orthodontic apparatus on mandibular condyle bone quality
Authors: Yüzbaşıoğlu Ertuğrul Betül
Published: January 2022

Aim: This study aims to compare the impact of dynamic functional orthodontic appliances on mandibular condyle bone density in patients with Class I, Class II, and Class III malocclusion during their growth and development phases.

Methodology: The histories of patients with three separate malocclusions who received dynamic functional orthodontic appliance treatment were analyzed in this retrospective study. Twenty-eight patients met the inclusion criteria and were divided into four groups: maxillary expansion devices (Group A), twinblock/monoblock devices (Group B), face masks (Group C), and chincups (Group D). The fractal analysis approach was used to determine the mandibular condyle bone density by analyzing panoramic films taken from the patients at the beginning (T0) and end (T1) of treatment.

Results: In Groups A and B, the results of the mandibular condyle bone fractal analysis decreased at the end of treatment compared with the pre-treatment results (p < 0.05). In Groups C and D, the post-treatment results were better than the pre-treatment ones (p < 0.05).

Conclusion: Among the different malocclusion groups, some dynamic functional orthodontic appliances (maxillary expansion and twinblock/monoblock devices) enabled an increase in bone density in the mandibular condyle, while some (face masks and chincups) decreased the density. It is important to conduct orthodontic treatment by analyzing the results obtained with the use of these appliances.

 

How to cite this article: Yüzbaşıoğlu Ertuğrul B. Effects of removable functional orthodontic apparatus on mandibular condyle bone quality. Int Dent Res 2021;11(Suppl.1):7-11. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.2

 

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Evaluation of the stress distribution in the cortical bone caused by variations in implant applications in patients with bruxism: A three-dimensional finite element analysis
Authors: Kantaci Yakup , Ülkü Sabiha Zelal
Published: January 2022

Aim: To evaluate the stress distribution in the cortical bone under parafunctional forces with different occlusal thicknesses, monolithic zirconia with different implant diameters, and number variations in implant-supported fixed prosthetic restorations applied in patients with bruxism.

Methodology: The tomographic sections of the previously registered mandible were used in order to model the mandible. Modeled bone height is 30 mm, cortical bone thickness is 1.5 mm, and trabecular bone thickness is modeled as 13 mm. By placing two implants in the created bone model, a three-member main model (Group 1), the number of implants was increased, three implants supported the Group 2 models, the diameter of the implants was increased, and the Group 3 models were created. The created Group 1, 2, 3 models, the occlusal thickness was divided into subgroups with 1.0, 1.5, and 2.0 mm, respectively (Groups A, B, and C). The groups were applied in two directions: vertical and 30o oblique. Stress values under forces were analyzed by finite element stress analysis.

Results: Under vertical loading, the maximum principal stress value in the cortical bone was found to be lowest in Group 2C, and the highest maximum principal stress value was found in Group 1A. The minimum principal stress value in the cortical bone was found to be the lowest in Group 3C, and the highest minimum principal stress value was found in Group 1A. Under oblique loading, the maximum principal stress value in the cortical bone was found to be the lowest in Group 3C and the highest maximum principal stress value was found in Group 1A. The minimum principal stress value in the cortical bone was found to be lowest in Group 3C, and the highest minimum principal stress value was found in Group1A.

Conclusion: Stresses caused by oblique forces are more than vertical forces. Increasing the occlusal thickness of the implant fixed prosthesis material, implant diameter, and number reduce the minimum and maximum principal stress values in the cortical

 

How to cite this article: Kantaci Y, Ülkü SZ. Evaluation of the stress distribution in the cortical bone caused by variations in implant applications in patients with bruxism: A three-dimensional finite element analysis. Int Dent Res 2021;11(Suppl.1):194-200. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.27

 

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Examination of the stresses of the implants applied to the atrophic edentulous maxilla on the maxillary bone
Authors: Çetindağ Aykut , Gülsün Belgin
Published: January 2022

Aim: In advanced atrophy of the posterior maxilla, applied zygoma implants increase the success of the surgical procedure by reducing morbidity and procedure time. In our study, using tomographic records, a model with posterior atrophy was obtained in a computer environment, and zygomatic and dental implants in different numbers and localizations were applied to this model. The aim of our study was to choose the most accurate surgical planning according to the stresses arising from the applied forces.

Methodology: In our study, one zygoma implant on the right and left in Group 1, two zygoma implants in Group 2, one zygoma implant in Group 3 and one dental implant in the first premolar tooth area, one zygoma implant in Group 4 and one dental implant in the lateral tooth area and one zygoma implant in Group 5 and one dental implant in the lateral and a first premolar tooth area were applied. 150 N were applied vertically to the prosthetic superstructure from the lateral tooth, 1st premolar tooth, 1st molar tooth and 2nd molar tooth. As a result of the applied forces, the maximum stress values ​​in the maxilla molar region were examined by finite element stress analysis.

Results: In our study, it was observed that Group 1 had the highest stress value, followed by Group 3. Stress values in Groups 2, 4 and 5 were low and they were measured close to each other.

Conclusion: As a result of our study, it was seen that zygomatic and dental implants applied in addition to the zygomatic implant reduce stress and the localization of dental implants affect the stress values.

 

How to cite this article: Gülsün B, Çetindağ A. Examination of the stresses of the implants applied to the atrophic edentulous maxilla on the maxillary bone. Int Dent Res 2021;11(Suppl.1):210-5. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.30

 

 

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Evaluation of liquid sorption and color stability of dental composites after exposure to common lactation teas
Authors: Yıldırım Bilmez Zuhal , Şeker Oya , Köse Hazal Deniz , Gözüyeşil Aslan Başak
Published: January 2022

Aim: To assess the effects of common lactation teas on liquid sorption and color stability of three different dental composites.

Methodology: A total of 60 samples (n = 5) were examined from three composite materials: Omnichroma (Tokuyama Dental Co., Tokyo, Japan), Estelite Posterior, (Tokuyama Dental Co., Tokyo, Japan), and Mosaic Universal (Ultradent production Inc., South Jordan, UT, USA). Samples measuring 2x6 mm were taken and immersed in three different teas—Humana (Humana, Bremen, Germany), Hipp, (Hipp, Pfaffenhofen, Germany), and Lactamil (Nutricia, Friedrichsdorf, Germany) —as well as artificial saliva. The measurements were recorded at baseline and on the 7th day. A sensitive analytical balance was used to measure liquid sorption, and a VITA Easy Shade device was used for color measurements. Absorption and Delta E values ​​were calculated. The data were analyzed using MANOVA at a significance level of (p<0.05).

Results: Composite materials, solutions, and their interactions had a statistically significant effect on the sorption and Delta E values (p<0.001). The relative liquid absorption values among the composites were recorded as follows: Tokuyama>Mosaic>Omnichroma. Humana had the highest and Hipp had the lowest mean value among the solutions (p<0.001). For Delta E, Mosaic had the highest mean value among the composites, and Lactamil had the highest mean value among the solutions (p<0.001).

Conclusion: Lactation teas cause discoloration in dental composites. In vitro and in vivo studies on color changes in dental composites are needed due to the sorption of these fluids.

 

How to cite this article: Özüdoğru S, Tosun G. Survival and clinical evaluation of various space maintainers used for early primary tooth loss. Int Dent Res 2021;11(Suppl.1):222-7.

https://doi.org/10.5577/intdentres.2021.vol11.suppl1.32

 

 

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Evaluation of the periodontal status of a patient diagnosed with Sheehan syndrome: A case report
Authors: Ceylan Şen Seval , Saygun Nuriye Işıl , Or Koca Arzu , Özcan Erkan
Published: January 2022

Aim: Some immunological changes occurring in mothers during pregnancy increase their susceptibility to infections, including periodontal infections. Sheehan syndrome (SS) is a disease that occurs because of severe postpartum hemorrhage causing ischemic pituitary necrosis. The presence of multiple hormonal deficiencies leads to the impairment of bone microarchitecture, which can cause osteopenia and even osteoporosis. Osteoporosis and periodontitis are both chronic diseases characterized by bone loss. Moreover, recent studies have shown that there is a relationship between menopause, osteoporosis, alveolar bone resorption, and tooth loss. This case report aims to evaluate the oral and periodontal status of a patient with SS and to raise awareness about dental and periodontal problems that may occur in such patients.

Methodology: A 63-year-old female patient diagnosed with SS in the endocrinology clinic was referred to the periodontology clinic with complaints of multiple tooth loss, mobility in her teeth, and gingival bleeding. In the clinical and radiographic examination of the patient, it was determined that all teeth had horizontal bone resorption; moreover, there was mobility in the mandibular anterior teeth and hemorrhage in the gums. When the patient’s laboratory results were examined, it was seen that the basal plasma levels of free triiodothyronine (T3) and thyroxine (T4), growth hormone (GH), prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone, and total testosterone values were significantly lower, and the anterior pituitary elevation was significantly decreased in pituitary magnetic resonance (MR) imaging.

Conclusion: The periodontium is the target tissue of sex and other hormones. Hormonal changes may affect the inflammatory–immune tissue responses of periodontal tissues. Many studies have shown that thyroid and sex hormones affect oral and especially periodontal tissues. The degradation of hormonal hemostasis may induce a series of pathological events in the oral environment, resulting in inflammatory changes in gingival tissues, periodontal attachment losses, and destruction of the alveolar bone. Systemic diseases that affect hormonal conditions, such as SS, must be considered in the evaluation of oral health. Medical physicians should refer their patients to the dentist for consultation when evaluating patients’ hormonal status and planning their treatment.

 

How to cite this article: Şen SC, Saygun NI, Or Koca A, Özcan E. Evaluation of the periodontal status of a patient diagnosed with Sheehan syndrome: A case report. Int Dent Res 2021;11(Suppl.1):308-11. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.46

 

 

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Is Google Trends a reliable way to determine digital dental epidemiology?
Authors: Üner Devrim Deniz , İzol Bozan Serhat
Published: January 2022

Aim: Google Trends, which allows Internet users to interact with and search data, can provide in-depth information about new phenomena regarding population and health-related behavior and is a tool that can be accessed free of charge. With the widespread use of dental implants in almost every country in the world today, an increase has also been reported in the prevalence of peri-implantitis (PP), which is a peri-implant disease. The aim of this study is to determine whether the rates of PP that were obtained from previous studies on this disease are in line with the data obtained using Google Trends.

Methodology: Using observational, ecological research, we searched Google Trends for the following query terms: peri implantitis + periimplantitis, to obtain the volume of this Internet search query. The queries were searched within Spain (ES), Germany (DE), the Netherlands (NL), the United Kingdom (UK), and Turkey from January 2010 to December 2019.

Results: An examination of the search results for “peri-implantitis + peri-implantitis” on Google Trends found that the largest numbers of searches for these words were made from the country of ES, and the smallest numbers were made from Turkey. It took two years to make forecasts based on the results, and the study determined that there has been a change in the trends in countries that were searched for these words. Also, the results obtained in previous studies for the prevalence of peri-implantitis were not similar to the data obtained from Google Trends.

Conclusion: We concluded in this study that Google Trends is not a reliable tool for dental epidemiology.

 

How to cite this article: Üner DD, İzol BS. Is Google Trends a reliable way to determine digital dental epidemiology? Int Dent Res 2021;11(Suppl.1):38-46. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.7

 

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Analysis of equal access to education on the example of Roma students in Chorzów and Bytom
Authors: Styrkacz Sonia
Published: January 2022

The article was prepared as part of the project: Promoting equal access to quality education for Roma children, implemented
by Contact Point for Roma and Sinti Issues in Europe. The study consists of three parts. The first one concerns the basic information related to the analysis of the current state of knowledge on equal access to education of Roma children in Poland, the second – indicates the current statistical data on the education of Roma children, and the final part, which is a summary – presents the results of research and recommendations for practice in to improve communication between Roma parents and officials and teaching staff. The pilot study was aimed at identifying problems related to equal access to education of Roma children at the preschool and kindergarten level. They were conducted in Silesia – in Chorzów and Bytom – using the method of a structured interview. An interview with school principals,
officials, and Roma’s parents revealed a significant need to build a bridge based on trust and fluent communication.
A rare cause of insidious shoulder pain in a young female: A soft tissue aneurysmal bone cyst in supraspinatus muscle
Authors: Süzen Özbayrak Sibel , Geler Külcü Duygu
Published: January 2022

Aneurysmal bone cyst (ABC) is an expansile cystic lesion which may affect any bone of the skeleton. Although extremely rare, lesions with histomorphological characteristics of an ABC occur in the soft tissue. Herein, we report the first case of ABC involving the supraspinatus muscle and mimicking common pathologies, such as myofascial pain syndrome or subacromial impingement syndrome.
Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
Authors: Okçu Mehmet , Aybala Koçak Fatmanur , Sancar Kaya Samet , Tuncay Figen
Published: January 2022

Bisphosphonates are commonly used in the treatment of osteoporosis. Atypical femoral fracture (AFF) is a well-known adverse effect of bisphosphonate use. The importance of genetic factors has been demonstrated in bone quality, bone turnover, and in the response to osteoporosis treatment. Herein, we present two cases of bilateral AFFs after bisphosphonate use for a short period of time in members of the same family (mother and her daughter) and discuss genetic predisposition to bisphosphonate-induced AFFs in the light of literature data.
Pregabalin as a probable cause of central serous chorioretinopathy: Two case reports
Authors: Emre Doğan Yusuf , Neslihan Kurt Oktay Kübra , Buyru Özkurt Yelda , Aktaş İlknur
Published: January 2022

Pregabalin is commonly used for the treatment of neuropathic pain and is attributed to adverse effects of peripheral vasodilation and peripheral edema. Central serous chorioretinopathy (CSCR) is characterized by choroidal fluid leaks from choroidal vessels under the retina, causing focal retinal detachment with macular vision loss. Herein, we report two cases admitted to our clinic with vision loss while under pregabalin treatment. Upon eye examination, both patients were diagnosed with acute CSCR. Pregabalin treatment was discontinued upon the diagnosis of CSCR. We consider that the use of pregabalin in the presented two cases may be the causal effect of the CSCR diagnosis, as pathophysiology of CSCR is in parallel with the edema-related adverse effects of pregabalin.
Validity and reliability of the Turkish version of the lymphedema symptom intensity and distress survey
Authors: Deveci Zeynep , Karayurt Özgül , Çelik Buket , Eyigör Sibel
Published: January 2022

Objectives: This study aims to adapt the Lymphedema Symptom Intensity and Distress Survey- Arm (LSIDS-Arm) into Turkish and to test its validity and reliability.

Patients and methods: Between September 2017 and July 2018, this descriptive, methodological study included a total of 186 women (mean age: 55.4±10.2 years; range, 20 to 80 years) who were diagnosed with breast cancer-related lymphedema (BCRL) and followed in the lymphedema outpatient clinic. Data were collected using sociodemographic and clinical features form, LSIDS-Arm, and Functional Assessment of Cancer Treatment-Breast Cancer Scale+4 (FACT-B+4). After the linguistic and content validity of the scale was achieved, confirmatory factor analysis and known-groups validation were utilized to test the construct validity. Reliability of the survey was tested using the Cronbach alpha and Spearman Brown coefficient, item analysis, and parallel forms reliability.

Results: All patients completed the questionnaire. After achievement of linguistic and content validity, confirmatory factor analysis results were found to be higher than the accepted value. Known-groups validation revealed a significant difference in the mean scores for the intensity and distress scales between the patients with and without lymphedema. Cronbach alpha for the subscales ranged from 0.61 to 0.86. Parallel forms reliability showed a moderate, significant correlation between subscales of the intensity and distress scales of the survey and the subscales of FACT-B+4.

Conclusion: The Turkish version of the survey is valid and reliable and can be used to evaluate symptoms, severity of symptoms, and distress caused by BCRL symptoms in the Turkish women.
Effects of a combination of scapular stabilization and thoracic extension exercises for office workers with forward head posture on the craniovertebral angle, respiration, pain, and disability: A randomized-controlled trial
Authors: Kang Na-Yeon , Im Sang-Cheol , Kim Kyoung
Published: January 2022

Objectives: This study aims to investigate how exercise programs not directly applied to the cervical spine affect office workers with forward head posture (FHP).

Patients and methods: Between March 2018 and June 2018, a total of 32 office workers with FHP (13 males, 19 females; mean age 36.63 years; range, 23 to 57 years) were randomized either to experimental (n=16) or control groups (n=16). Scapular stabilization and thoracic extension exercises were applied to the experimental group and cervical stabilization and stretching exercises to the control group. The results of the pre-intervention and after six weeks measurement of the craniovertebral angle (CVA), respiration, pain, and disability were compared and analyzed.

Results: For intra-group comparison, both groups showed significant differences (p<0.05) in CVA, forced expiratory volume at 1 sec (FEV1), Visual Analog Scale (VAS), and neck disability index at pre- and post-intervention, while only the experimental group showed a significant difference (p<0.05) in maximum inspiratory pressure, maximum expiratory pressure, and forced vital capacity. For inter-group comparison, a significant difference (p<0.05) between FEV1 and VAS was observed.

Conclusion: The combination of scapular stabilization and thoracic extension exercises, not directly applied to the cervical spine, has an effect on improving the posture, respiration, neck pain, and disability in office workers with FHP.
Effect of estrogen and progesterone on nerve conduction studies during ovarian cycle
Authors: Ustaömer Kübra , Sözay Seyhan , Sarıfakıoğlu Banu
Published: January 2022

Objectives: This study aims to investigate the effects of estrogen and progesterone on nerve conduction studies (NCSs) in three different hormonal phases of the ovarian cycle.

Patients and methods: Between April 2008 and July 2008, a total of 40 healthy volunteer women (mean age: 24.1±5.1 years; range 21 to 43 years) with regular menstrual cycles were included in this prospective study. The participants were regularly menstruating for at least one year, without any hormonal disease and without taking any medication that could lead to hormonal dysregulation. Motor and sensory conduction velocities, amplitudes, and distal latencies were analyzed at the dominant extremities within the early follicular phase (EFP), late follicular phase (LFP), and the midluteal phase (MLP).

Results: Except for the median nerve motor conduction velocity (MCV), there were no statistically significant differences between the peripheral NCS results in the three ovarian cycle phases (p=0.033). After adjusting for multiple comparisons, a significant difference was found between the EFP and LFP (p=0.004).

Conclusion: Our study results showed that only median nerve MCV was affected in the menstrual cycle. However, this would be an incidental finding, or an increased sensibility of the median nerve motor fibers to ovarian steroids by an unknown mechanism. Further studies are warranted.
Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis: A prospective, randomized-controlled study
Authors: Karabaş Çağlar , Talay Çalış Havva , Serkan Topaloğlu Ulaş , Karakükçü Çiğdem
Published: January 2022

Objectives: In this study, we aimed to investigate the effectiveness of intra-articular platelet-rich plasma (PRP) injection in adhesive capsulitis.

Patients and methods: Between January 2019 and December 2019, a total of 40 patients (21 males, 19 females; mean age: 57.1±6.5 years; range, 44 to 72 years) with idiopathic adhesive capsulitis were included. The patients were randomly assigned into two equal groups as the PRP and the control group. The PRP group received two doses of PRP via intra-articular route biweekly under ultrasound guidance. No injection was performed to the control group. In both groups, stretching and Codman exercises were applied as a home- based program. The Visual Analog Scale (VAS), range of motion (ROM), and Shoulder Pain and Disability Index (SPADI) scores were evaluated before the treatment and at 2, 6 and 12 weeks after the treatment.

Results: There were significant differences in all VAS, SPADI, and ROM scores at all time points after treatment compared to baseline in both groups. At the end of the study, there were significant differences in the active flexion, passive flexion, active abduction, passive abduction, and active external rotation scores at 12 weeks between the groups (p=0.012, p=0.015, p=0.008, p=0.019, and p=0.040, respectively). No significant difference was observed between the groups in terms of VAS and SPADI scores and the other parameters (active and passive extension, active and passive internal rotation, passive external rotation) at 2, 6, and 12 weeks (p>0.05).

Conclusion: The addition of PRP to exercise treatment can improve patients' joint mobility, but not pain and disability in patients with adhesive capsulitis.
Vascular pectoralis minor syndrome as an overlooked condition: A case report
Authors: Aktaş İlknur , Kaya Ezgi , Akpınar Pınar , Ünlü Özkan Feyza , Vural Ahmet , Akgün Kenan
Published: January 2022

Thoracic outlet syndrome is characterized by pain, paresthesia, muscle weakness, and arterial/venous symptoms caused by compression of the neurovascular structures. Compression mainly occurs at three distinct areas in the thoracic outlet: the retropectoralis minor space, the costoclavicular space, and the interscalene triangle. As the symptoms of these three compression sites are very similar, it is difficult to pinpoint the location of the compression and the treatment methods are quite different. Ultrasound-guided diagnostic injections play an important role in the differential diagnosis. Herein, we report a 49-year-old female patient who was previously diagnosed with thoracic outlet syndrome and scheduled for decompression of cervical ribs, but cured by conservative methods after being diagnosed with pectoralis minor syndrome.
When is needle examination of thenar muscle necessary in the evaluation of mild and moderate carpal tunnel syndrome?
Authors: Özişler Zuhal , Akyüz Müfit
Published: January 2022

Objectives: This study aims to evaluate the predictors of standard nerve conduction study (NCS) parameters in determining the presence of axonal loss by means of spontaneous activity in patients with mild and moderate carpal tunnel syndrome (CTS).

Patients and methods: Between May 2015 and April 2018, a total of 118 patients (11 males, 107 females; mean age: 52.3±10.6 years; range, 27 to 79 years) who underwent electrophysiological studies and were diagnosed with CTS were included. Demographic data of the patients including age, sex, and symptom duration were recorded. Electrodiagnostic studies were performed in all patients. All the needle electromyography (EMG) findings were recorded, but only the presence or absence of spontaneous EMG activities was used as the indicator of axonal injury.

Results: In 37 (31.4%) of the patients, spontaneous activity was detected at the thenar muscle needle EMG. No spontaneous activity was observed in any of 43 (36.4%) patients with normal distal motor latency (DML). There were significant differences in DMLs, compound muscle action potential (CMAP) amplitudes, sensory nerve action potentials amplitudes, and sensory nerve conduction velocities between the groups with and without spontaneous activity (p<0.05). The multiple logistic regression analysis revealed that DML was a significant independent risk variable in determining presence of spontaneous activity. The most optimal cut-off value for median DML was calculated as 4.9 ms. If the median DML was >4.9 ms, the relative risk of finding spontaneous activity on thenar muscle needle EMG was 13.5 (95% CI: 3.6-51.2).

Conclusion: Distal motor latency is the main parameter for predicting the presence of spontaneous activity in mild and moderate CTS patients with normal CMAP. Performing needle EMG of the thenar muscle in CTS patients with a DML of >4.9 ms may be beneficial to detect axonal degeneration in early stages.
Anti-EU Backlash from Below or Above? Public Opinion in Central and Eastern Europe Prior to the 2015 Migration Crisis
Authors: Petrvić Nikola , Mrakovčić Marko , Fila Filip
Published: January 2022

Relations between Brussels and Central and Eastern Europe (CEE) worsened during and after the 2015 migration crisis. In order to see to what extent CEE citizens contributed to and/or resonated with this new state of affairs, this paper investigates public opinion before the migration crisis in seven CEE EU Member States. We inquire whether the main issues of the rift (CEE political elites’ opposition to following EU decisions and immigration and their emphasis on sovereignism, nationalism, Christian Europe and historical traumas) could also be traced to public stances towards these issues before the migration crisis. We used the ISSP National Identity module conducted in 2013 and 2014 in the Czech Republic, Estonia, Croatia, Hungary, Lithuania, Latvia and Slovenia. The results show that opposition to EU supranationalism was not linked to ethnic nationalism and religious identity (except in Hungary). Contrary to political elites, who emphasised the cultural threat posed by migration, public opinion was more concerned with the economic threat. Moreover, the perception of cultural threat was not linked to opposing EU supranationalism in any of the countries. However, particularly support for sovereignism (in almost all the countries), but also pride in national history (in some countries) correlated negatively with support for EU supranationalism. The results suggest that political elites can bypass public opinion to construct an anti-EU climate, however not out of thin air. The conditions for such a process were present in Hungary with its emerging transnational cleavage, which shows the importance of cleavages in studying Euroscepticism.