bluuebunny/crossref_metadata_2025 huggingface dataset:
Review of the Effectiveness of Various Adjuvant Therapies in Treating Mycobacterium tuberculosis
Authors: Amin Arman , Vartanian Artin , Yegiazaryan Aram , Al-Kassir Abdul Latif , Venketaraman Vishwanath
Published: September 2021

Tuberculosis disease is caused by the bacterium Mycobacterium tuberculosis. It is estimated that 10 million people have developed tuberculosis disease globally, leading to 1.4 million deaths in 2019. Treatment of tuberculosis has been especially challenging due to the rise of multidrug-resistant (MDR-TB) and extensive drug-resistant (XDR-TB) tuberculosis. In addition to drug-resistant genotypes, the standard treatment of tuberculosis by first-line agents is also challenging due to toxicity and costs. In the last four decades, there have only been two new anti-tuberculosis agents—bedaquiline and delamanid. Therefore, shorter, safer, and more cost-effective therapies are needed to adequately treat tuberculosis. In this review, we explore various adjuvants such as glutathione, everolimus, vitamin D, steroid, aspirin, statin, and metformin and their usefulness in reducing the burden of tuberculosis. Glutathione, everolimus, aspirin, and metformin showed the most promise in alleviating the burden of tuberculosis. Despite their potential, more clinical trials are needed to unequivocally establish the effectiveness of these adjuvants as future clinical therapies. Methods: The journals for this review were selected by conducting a search via PubMed, Google Scholar, and The Lancet. Our first search included keywords such as “tuberculosis” and “adjuvant therapy.” From the search, we made a list of adjuvants associated with tuberculosis, and this helped guide us with our second online database search. Using the same three online databases, we searched “tuberculosis” and “respective therapy.” The adjuvants included in the paper were selected based on the availability of sufficient research and support between the therapy and tuberculosis. Adjuvants with minimal research support were excluded. There were no specific search criteria regarding the timing of publication, with our citations ranging between 1979 to 2021.
Lived Experiences of African Migrants Crossing the Strait of Gibraltar to Europe: A Cross-Cultural Approach to Healthcare from a Qualitative Methodology
Authors: Ponce-Blandón José Antonio , Romero-Castillo Rocío , Jiménez-Picón Nerea , Palomo-Lara Juan Carlos , Castro-Méndez Aurora , Pabón-Carrasco Manuel
Published: September 2021

Background: The migratory flow from the African continent to Europe is intense and the European countries should apply a humanitarian, health and social response to this emerging problem. Migrants coming from Africa to Europe are a very vulnerable population. Healthcare professionals should be prepared for answering their needs from a transcultural approach, which requires a better understanding of this phenomenon. Thus, the aim of this study was to improve nursing and healthcare professionals’ awareness and better understanding of migrant life experiences during the migration journey. An exploratory descriptive qualitative research was conducted. In-depth interviews were conducted involving four key informants and content analysis were performed with the transcriptions. Results: Three themes merged: life situations in their countries of origin; motivations that led them to undertake the migratory journey; and experiences they lived during the migratory journey. The results described the dramatic experience and motivations for crossing the strait of Gibraltar from Africa to Europe, including feelings, fears, hopes and lived experiences. The determination of immigrants to fight for a better life opportunity and the physical damage and psychological consequences they suffer were revealed. Conclusions: This study would help healthcare professionals to better understand this complex reality and deliver culturally adapted care. Knowledge of the starting reality of these populations can help health professionals to incorporate a cross-cultural approach that improves the relational, ethical and affective competences to provide quality care to the migrant population, as well as the development of health measures to fight against inequalities suffered by these population groups.
Assessing Disparity Using Measures of Racial and Educational Isolation
Authors: Bravo Mercedes A. , Leong Man Chong , Gelfand Alan E. , Miranda Marie Lynn
Published: September 2021

We develop a local, spatial measure of educational isolation (EI) and characterize the relationship between EI and our previously developed measure of racial isolation (RI). EI measures the extent to which non-college educated individuals are exposed primarily to other non-college educated individuals. To characterize how the RI-EI relationship varies across space, we propose a novel measure of local correlation. Using birth records from the State of Michigan (2005–2012), we estimate associations between RI, EI, and birth outcomes. EI was lower in urban communities and higher in rural communities, while RI was highest in urban areas and parts of the southeastern United States (US). We observed greater heterogeneity in EI in low RI tracts, especially in non-urban tracts; residents of high RI tracts are likely to be both educationally and racially isolated. Associations were also observed between RI, EI, and gestational length (weeks) and preterm birth (PTB). For example, moving from the lowest to the highest quintile of RI was associated with a 1.11 (1.07, 1.15) and 1.16 (1.10, 1.22) increase in odds of PTB among NHB and NHW women, respectively. Moving from the lowest to the highest quintile of EI was associated with a 1.07 (1.02, 1.12) and 1.03 (1.00, 1.05) increase in odds of PTB among NHB and NHW women, respectively. This work provides three tools (RI, EI, and the local correlation measure) to researchers and policymakers interested in how residential isolation shapes disparate outcomes.
The Association of Interpersonal Relationships and Social Services with the Self-Rated Health of Spanish Homelessness
Authors: Fajardo-Bullón Fernando , Pérez-Mayo Jesús , Esnaola Igor
Published: September 2021

Understanding the specific factors associated with poor health is critical to improve the health of homeless people. This study aimed to analyze the influence of personal variables, interpersonal relationships, and the influence of social services on the health of homeless people. A secondary analysis was applied to cross-sectional data from a sample of 1382 homeless people living in the Basque Country (Spain) (75.69% male). Multinomial logistic regression modelling was used to analyze the relationship between health and personal variables, interpersonal variables, perceived help and use of the social services. Relationships with the family, using a day center, and a sufficient and high perceived help of the social services were significant factors associated with good health. On the other hand, spending the day alone or using mental and health care services are associated with poor health. In the same way, the longer a person has been homeless, the worse their expected state of health is. Addressing housing exclusion, promoting interpersonal relationships, using a day center, and developing the use and perceived helpfulness of social services stand out as key factors in improving health status. Social policies are usually focused on housing. However, this paper also highlights the relevance of developing interpersonal relationships and using day centers to improve homeless people’s health.
Review and Improvement of Chemical Hazard Risk Management of Korean Occupational Safety and Health Agency
Authors: Shin Saemi , Byeon Sang-Hoon
Published: September 2021

In 2012, the Korean Occupational Safety and Health Agency developed Chemical Hazard Risk Management (CHARM) as a risk assessment tool. This study aims to reorganize the CHARM technique by complementing its logical loopholes, while evaluating the risk to enterprises and verifying this technique by applying it to some enterprises in Korea. The optimized technique changed the method of quantitative assessment and evaluation criteria, matched the risk level with the required control level, and specified the use of control practice. For the target enterprises, for several assessment methods, risk levels, hazard bands, exposure bands, and the risk assessment results were derived, and the same types of options were compared. Fewer informational methods resulted in more conservative results of risk levels and hazard bands. Since the control status of the enterprises could not be confirmed and the substances handled at the target enterprises were limited in this study, a follow-up study should be performed with more target materials and additional information on the current control status of the enterprises.
Development of a Culturally Anchored Qualitative Approach to Conduct and Analyze Focus Group Narratives Collected in Diné (Navajo) Communities to Understand the Impacts of the Gold King Mine Spill of 2015
Authors: Teufel-Shone Nicolette I. , Chief Carmenlita , Richards Jennifer R. , Clausen Rebecca J. , Yazzie Alfred , Begay Manley A. , Lothrop Nathan , Yazzie Janene , Begay Andria B. , Beamer Paloma I. , Chief Karletta
Published: September 2021

The Gold King Mine Spill (Spill) occurred in August 2015 upstream from Silverton, Colorado and released three million gallons of contaminated water into the Animas River, a tributary to the San Juan River that flows across the Navajo Nation. Using principles of community-engaged research, the Gold King Mine Spill Diné Exposure Project co-developed a culturally anchored approach to conduct focus groups and analyze narratives collected in three Diné (Navajo) communities along the San Juan River within 9 months of the Spill. Focus group questions were designed to document the socio-cultural impacts of the Spill. This paper: (1) outlines the partnerships and approvals; (2) describes focus group design, training, data collection and analysis; and (3) reflects on the use of a culturally anchored approach in Indigenous, specifically Diné-centered research. Diné social and cultural etiquette and concepts of relationality were used to adapt standard (non-Indigenous) qualitative methods. Findings describe community perceptions of short-term impacts of the disaster, as well as past and present injustices, communication related to the Spill, and concerns of persistent threats to Diné lifeways. The culturally anchored approach was critical in fostering trust with Diné participants and aligned with the candor of the discussions.
Adaptation and Psychometric Validation of the EMPOWER-SUSTAIN Usability Questionnaire (E-SUQ) among Patients with Metabolic Syndrome in Primary Care
Authors: Sahar Nurul Hidayatullaila , Badlishah-Sham Siti Fatimah , Ramli Anis Safura
Published: September 2021

Self-management support is one of the most important components of the Chronic Care Model (CCM). The EMPOWER-SUSTAIN Global Cardiovascular Risks Self-Management Booklet© was developed for patients with Metabolic Syndrome (MetS), inspired by the CCM. Assessing usability of a self-management tool is important in chronic disease management. However, there was no available instrument to assess usability of a self-management booklet, as most instruments were developed to assess usability of mobile application. Therefore, this study aimed to adapt Skala Kebolehgunaan Aplikasi Mudah Alih (SKAMA) into the EMPOWER-SUSTAIN Usability Questionnaire (E-SUQ) and to determine its validity and reliability in assessing usability of a self-management booklet. A cross-sectional validation study was conducted among patients with MetS attending a university primary care clinic in Selangor, Malaysia. Content validation, adaptation and face validation of E-SUQ were performed according to recommended guidelines. It underwent two rounds of content validation as major revision was required for item 5. Subsequently, the revised E-SUQ was face-validated by 10 participants. Psychometric evaluation was conducted using principal component analysis with varimax rotation to determine the underlying structure of E-SUQ. Internal consistency reliability was assessed using Cronbach’s α coefficient and the test-retest reliability was assessed using intraclass correlation coefficient (ICC (2,k)). A total of 205 patients participated in the study. The item-level content-validity-index (I-CVI) for item 5 improved from 0.57 to 1.0 after the second round of content validation. The final S-CVI/Ave value for ESUQ was >0.90. The item-level face-validity-index (I-FVI) ranged between 0.9 and 1.0. Kaiser-Meyer-Olkin value of 0.871 and Bartlett’s test of sphericity p-value of <0.05 indicated good sample adequacy for factor analysis. Two factors with eigenvalues of >1 were extracted according to the Kaiser’s Criteria. The two extracted factors explained 60.6% of the cumulative percentage of variance. The elbow of the scree plot occurred between the second and third component, suggesting two factors to be retained. The two factors were consistent with “Positive” and “Negative” tone model. The overall Cronbach’s α coefficient was 0.77, indicating good internal reliability. The overall ICC was 0.85, indicating good reproducibility. The E-SUQ is shown to be valid, reliable and stable to measure the usability of a self-management booklet among patients with MetS in a university primary care clinic in Malaysia.
Correlation between the Ability to Manipulate a Touchscreen Device and Hand Strength and Manual Dexterity among Community-Living Older Individuals
Authors: Elboim-Gabyzon Michal , Danial-Saad Alexandra
Published: September 2021

Information regarding the relationship between the degree of hand function among the elderly as measured by traditional assessments and the ability to manipulate touchscreens is lacking. This study aimed to examine the correlation between the ability to manipulate a touchscreen device, as assessed using the touchscreen assessment tool (TATOO) (University of Haifa, Israel & Universetiy of Bologna, Italy), and hand strength and manual dexterity among independent community-living older individuals. Thirty-four community-living older adults (average age 79.4 ± 6.7 years) participated in single-session assessments lasting 45 min each. The assessment included hand strength measurement using the manual hand dynamometry and hydraulic pinch gauge, a functional dexterity test (FDT), and TATOO. No significant correlations were observed between most of the TATOO items (22 out of 26) and handgrip strength, pinch strength, and FDT results. Moderately significant correlations were demonstrated between the number of drag attempts in the “Drag to different directions” task and handgrip strength and manual dexterity (r value: −0.39, p value: 0.02; r value: 0.36, p value: 0.04, respectively). In addition, a moderately significant correlation was noted between the number of double taps and manual dexterity (r value: 0.32, p value: 0.07). These results indicate that more complex gestures that require greater accuracy (dragging task) or rapid movements (double tapping) are related to hand strength and manual dexterity. These results suggest that the manual gestures necessary for touchscreen operation entail unique and specific capabilities that are generally not captured by traditional tools. The clinical implication is that the hand function assessment toolbox should be expanded. Tools such as the TATOO should be used to capture skills required for touchscreen manipulation in the context of the modern digital milieu.
Pneumonia Risk Associated with the Use of Individual Benzodiazepines and Benzodiazepine Related Drugs among the Elderly with Parkinson’s Disease
Authors: Huang Kuang-Hua , Tai Chih-Jaan , Kuan Yu-Hsiang , Chang Yu-Chia , Tsai Tung-Han , Lee Chien-Ying
Published: September 2021

Most patients with Parkinson’s disease (PD) gradually develop oropharyngeal dysphagia which is often associated with pneumonia risk. The possible association of benzodiazepine (BZD) and benzodiazepine related drugs (BZRD) use with pneumonia risk has received increasing attention but remains controversial. We investigated pneumonia risk associated with the use of BZDs and BZRDs in older adult patients with PD. This case-control study analyzed data of 551,975 older adult patients with PD between 2001 and 2018 in Taiwan. To minimize potential confounding, we used 1:4 propensity score matching to include older adult patients without pneumonia as controls. Incident pneumonia risk was significantly higher in current (adjusted odds ratio (aOR) = 1.25, 95% CI = 1.23–1.27) and past (aOR = 1.13, 95% CI = 1.11–1.15) users of BZDs. Regarding BZRDs, recent (aOR = 1.08, 95% CI = 1.06–1.11) and past (aOR = 0.89, 95% CI = 0.88–0.91) users had higher and lower risks of incident pneumonia, respectively. Pneumonia risk varied based on their use of BZDs and BZRDs. In these individuals, incident pneumonia risk was high in users of BZDs, such as midazolam, lorazepam, flunitrazepam, estazolam, and clonazepam. Regarding the use of BZRDs, zopiclone increased incident pneumonia risk.
Impact of the Result of Soccer Matches on the Heart Rate Variability of Women Soccer Players
Authors: Ayuso-Moreno Rosa Mª. , Fuentes-García Juan Pedro , Nobari Hadi , Villafaina Santos
Published: September 2021

The present study aimed to evaluate the effects of a match lost and a match won on post-competitive heart rate variability (HRV) in semi-professional female soccer athletes. A total of 13 players, with a mean age of 23.75 (5.32), from the Cáceres Women Football Club of the Spanish Second National Division participated in our study. They were evaluated in two microcycles which correspond to a match lost and a match won. For each microcycle, baseline and post-competitive measures were collected. Results indicate that HRV was significantly reduced before a match lost and won. Significant differences in HRV variables were observed when compared the lost match, and the match won. Results highlight the importance and usefulness of analyzing the HRV as an indicator of post-competitive fatigue in semiprofessional soccer players. Therefore, a competition’s results could be considered a relevant variable to consider when programming training load.
Health-Related Quality of Life and Frequency of Physical Activity in Spanish Students Aged 8–14
Authors: Calzada-Rodríguez José I. , Denche-Zamorano Ángel M. , Pérez-Gómez Jorge , Mendoza-Muñoz María , Carlos-Vivas Jorge , Barrios-Fernandez Sabina , Adsuar José Carmelo
Published: September 2021

The study of health-related quality of life (HRQoL) in children and adolescents has important implications in terms of policy, education, and health. Data on the time spent in physical activity (PA) and in sedentary activities in this population are worrying. We aim to analyze possible differences in HRQoL and PA levels between sexes and age groups in Spanish students aged between 8 and 14 years, as well as to assess the relationship between HRQoL and the frequency of PA in this population. A total of 3197 participants (1610 boys and 1587 girls) from 8 to 14 years old were recruited. Mquality and Mapping Child Health Utility instrument (Chu9d) were used as HRQoL indicators. A medium positive association between PA and HRQoL concerning the Spanish school population was found. HRQoL was higher among students aged 8 to 12 than 13 to 14. Moreover, when children start secondary education, both sexes seem to lose the quality of life. Similarly, PA decreases among girls over the years, although it seems to increase among boys. Thus, PA levels and HRQoL are directly associated in Spanish schoolchildren aged between 8 and 14 years. However, this HRQoL decreases in children over the years. Practical implications include the need to support education and physical activity programs to improve HRQoL in children and adolescents.
Development and Validation of a Scale for Interaction between Parents and Coaches of Middle and High School Golf Players
Authors: Hwang Jae-Wook
Published: September 2021

The purpose of this study was to develop a measurement tool for the interaction between parents and coaches of middle and high school golfers, and to verify its validity. A total of 563 parents participated in the study. Based on the results of preliminary item production, item analysis, reliability analysis, exploratory factor analysis, identification factor analysis, job uniformity analysis, and potential mean comparison analysis, the initial 70 items were constructed according to the conceptualization of parent–coach interactions. The first and second item reduction processes and preliminary surveys were conducted through expert meetings to produce the final 40 items of parent–coach interactions. After eliminating 20 items through question analysis, reliability analysis, and exploratory factor analysis, the final three factors of parent–coach interaction were extracted, and the conformity index for the middle and high school golfers’ parent-to-coach interaction tool was checked. Then, to ensure the external validity of the developed parent–coach interaction measurement tool, a construct equivalence analysis was conducted to demonstrate that the tool can be applied equally to parents and coaches. In summary, the tools for measuring the interaction between the middle and high school golfers’ parents and coaches were developed in 20 questions, three factors for communication, qualification, and support, and it was confirmed that the developed measuring tools could all be applied equally through a latent mean analysis. Parents and coaches are key variables that can affect a player’s performance; thus parents and coaches’ interaction measuring tools can be provide positive information not only for golfers but also for players of various other sports.
Development and Comparison of Dengue Vulnerability Indices Using GIS-Based Multi-Criteria Decision Analysis in Lao PDR and Thailand
Authors: Zafar Sumaira , Shipin Oleg , Paul Richard E. , Rocklöv Joacim , Haque Ubydul , Rahman Md. Siddikur , Mayxay Mayfong , Pientong Chamsai , Aromseree Sirinart , Poolphol Petchaboon , Pongvongsa Tiengkham , Vannavong Nanthasane , Overgaard Hans J.
Published: September 2021

Dengue is a continuous health burden in Laos and Thailand. We assessed and mapped dengue vulnerability in selected provinces of Laos and Thailand using multi-criteria decision approaches. An ecohealth framework was used to develop dengue vulnerability indices (DVIs) that explain links between population, social and physical environments, and health to identify exposure, susceptibility, and adaptive capacity indicators. Three DVIs were constructed using two objective approaches, Shannon’s Entropy (SE) and the Water-Associated Disease Index (WADI), and one subjective approach, the Best-Worst Method (BWM). Each DVI was validated by correlating the index score with dengue incidence for each spatial unit (district and subdistrict) over time. A Pearson’s correlation coefficient (r) larger than 0.5 and a p-value less than 0.05 implied a good spatial and temporal performance. Spatially, DVIWADI was significantly correlated on average in 19% (4–40%) of districts in Laos (mean r = 0.5) and 27% (15–53%) of subdistricts in Thailand (mean r = 0.85). The DVISE was validated in 22% (12–40%) of districts in Laos and in 13% (3–38%) of subdistricts in Thailand. The DVIBWM was only developed for Laos because of lack of data in Thailand and was significantly associated with dengue incidence on average in 14% (0–28%) of Lao districts. The DVIWADI indicated high vulnerability in urban centers and in areas with plantations and forests. In 2019, high DVIWADI values were observed in sparsely populated areas due to elevated exposure, possibly from changes in climate and land cover, including urbanization, plantations, and dam construction. Of the three indices, DVIWADI was the most suitable vulnerability index for the study area. The DVIWADI can also be applied to other water-associated diseases, such as Zika and chikungunya, to highlight priority areas for further investigation and as a tool for prevention and interventions.
Regional Travel as an Alternative Form of Tourism during the COVID-19 Pandemic: Impacts of a Low-Risk Perception and Perceived Benefits
Authors: Wang Xin , Lai Ivan Ka Wai , Zhou Quan , Pang Yu He
Published: September 2021

Previous COVID-19 tourism research has not considered the positive impact of a low-risk perception and a perception of the benefits of regional travel on taking alternative tourism. This study attempts to fill the research gap and examine the positive effect of these perceptions on tourists’ attitudes to regional travel and intentions to undertake regional travel during the COVID-19 pandemic. A survey of 278 respondents confirmed that the perceived benefit positively influences tourists’ attitudes and travel intentions, but that a low-risk perception only positively affects their attitudes. This study contributes to tourism risk management research by introducing the concept of a low-risk perception as a positive factor. For tourism recovery, it finds that relaxation, value, and convenience are benefits to drive people to travel.
Evaluation of Capillary Blood Gases in Medical Personnel Caring for Patients Isolated Due to SARS-CoV-2 in Intensive Care Units before and after Using Enhanced Filtration Masks: A Prospective Cohort Study
Authors: Mędrzycka-Dąbrowska Wioletta , Ślęzak Daniel , Robakowska Marlena , Żuratyński Przemysław , Krzyżanowski Kamil , Małecka-Dubiela Anna , Dąbrowski Sebastian , Zorena Katarzyna , Lewandowska Katarzyna , Ozga Dorota , Chmielarz Karina , Buca Paulina , Tomaszek Lucyna
Published: September 2021

The dynamically changing epidemiological situation caused by the SARS-CoV-2 virus is associated with the increased burden and fatigue of medical personnel. The aim of the study was to evaluate: (1) oxygen and carbon dioxide blood pressure and saturation levels in medical personnel caring for patients isolated due to SARS-CoV-2 in ICUs; (2) adverse symptoms reported by medical personnel after leaving the isolation zone. Design: A Prospective Cohort Study. Methods: The project was implemented in the first quarter of 2021. Medical personnel working with patients isolated due to SARS-CoV-2 in the ICU of three hospitals were eligible for the study. The participants of the study were subjected to two analyses of capillary blood by a laboratory diagnostician. Results: In the studied group of medical personnel (n = 110) using FFP2/FFP3 masks, no significant differences (p > 0.05) were found between the parameters of geometric examination performed before and after leaving the isolation ward of the hospital. After working in the isolation ward, nurses reported malaise (somnolence, fatigue, sweating, dizziness) more often than paramedics (44% vs. 9%; p = 0.00002). The risk of ill-being in nurses was approximately nine times higher than in paramedics (OR = 8.6; Cl 95%: 2.7 to 26.8) and increased with the age of the subjects (OR = 1.05; Cl 95%: 1.01 to 1.08). Conclusion: FFP2/FFP3 filter masks did not worsen blood oxygenation in medical staff caring for patients isolated due to SARS-CoV-2 in the ICU. The presence of subjective symptoms such as fatigue may be due to lack of adequate hydration.
The Influence of Intrapersonal, Interpersonal, and Community Protective Factors on Hong Kong Adolescents’ Stress Arising from Political Life Events and Their Mental Health
Authors: Chang Ching-Wen , To Siu-Ming , Chan Wallace Chi-Ho , Fong Alex Ching-Pong
Published: September 2021

Precarious political circumstances can take a mental toll on young people. Adopting a socio-ecological perspective, this study investigated the influence of stress arising from political life events, intrapersonal factors (i.e., meaning in life, resilience), interpersonal factors (i.e., social support, associational social capital), and community factors (i.e., perceived empowerment in the community, perceived opportunities for civic engagement) on the mental health of youth in Hong Kong. Furthermore, it examined the moderating effects of these factors on the relationship between stress arising from political life events and mental health. A cross-sectional quantitative survey with a stratified purposive sampling data collection method was conducted. A total of 1330 secondary school students were recruited for this study. Multiple regression analysis was performed to examine both direct and moderation effects. The results indicate that high stress arising from political life events, low meaningfulness in life, low resilience, low social support, low youth empowerment in the community, and high civic engagement in the community were related to high mental distress. None of the presumed moderators moderated the relationship between stress due to political life events and mental distress. Assessing and addressing stress due to political life events would be potentially important in mental health programs for Hong Kong adolescents in precarious political situations.
Spatial Association of Urban Form and Particulate Matter
Authors: Park Yunmi , Shin Jiyeon , Lee Ji Yi
Published: September 2021

Increasingly detrimental effects of fine particulate matter (PM) have been observed in Northeast Asia owing to its rapid economic development. Previous studies have found that dust, combustion, and chemical reactions are the major sources of PM; nevertheless, the spatial configuration of land use and land cover, which is of most interest to planners and landscape architects, also influences the PM levels. Here, we attempted to unveil the relationship between PM and different types of land use cover (i.e., developed, agricultural, woody, grass, and barren lands) in 122 municipalities of Korea. Landscape ecology metrics were applied to measure the spatial configuration of land use pattern and spatial lag models by taking into account the transboundary nature of air pollution, allowing us to conclude the following regarding PM levels: (1) the size of land cover type matters, but their spatial configuration also determines the variations in PM levels; (2) the contiguity and proximity of landcover patches are important; (3) the patterns of grasslands (e.g., simple, compact, and cluster (with large patches) patterns) and woodlands (e.g., complex, contiguous, and cluster (with large patches) patterns) considered desirable for minimizing PM are dissimilar in terms of contiguity.
Blended Care in In-Patient Acute Psychiatric Care. The Example of a Group Training for Social Competences in Adults—A Pretest–Posttest Feasibility Study
Authors: Bendig Eileen , Küchler Ann-Marie , Baumeister Harald , Becker Thomas
Published: September 2021

Introduction: Deficits in social skills can be an important modulating factor in the development and progress of various mental disorders. However, limited resources in inpatient care often impede effective social skills training. This study investigates the feasibility of a blended group training for social skills (SST) in an inpatient psychiatric setting. Methods and Analysis: For this one-group pretest–posttest trial, inpatients with a diagnosed mental disorder were recruited. Participation in the blended SST lasted four weeks and took place within usual inpatient psychiatric care. The blended intervention comprised four face-to-face group sessions and three complementary online modules within four weeks. Assessments took place before (t1) and after (t2) the training. Feasibility outcomes (use, acceptance, satisfaction, implementability into usual psychiatric inpatient care) and effectiveness outcomes regarding social skills were assessed. Results: N = 15 participants were recruited. Most patients completed all questionnaires (93%) and all modules of the blended SST concept (60%). All participants (100%) would recommend the blended intervention to a friend. Regarding social skills, exploratory analyses revealed a non-significant medium-sized effect (Cohen’s d = 0.5 95%CI 0.3 to 1.25, p = 0.08). Discussion: This trial shows that a blended care SST is feasible for the use in acute psychiatric inpatient care setting. Although the wards were acute, with high turnover and change of inpatients, 60% of participants were treated per protocol over four weeks. Overall, the evidence on blended care concepts in psychiatric care settings is extremely poor to date. Hence, this trial should encourage intensified blended inpatient psychiatric care research.
Finding the “Heart” in the Green: Conducting a Bibliometric Analysis to Emphasize the Need for Connecting Emotions with Biophilic Urban Planning
Authors: Tirri Christopher , Swanson Hunter , Meenar Mahbubur
Published: September 2021

Although there is a robust body of literature exploring the relationship between biophilic urban planning (BUP) and public health and well-being, there is a dearth of scholarship on the emotional components of BUP. It is crucial to understand these sentiment-related elements, so planners can assign “human value” to green spaces as a strategy for emphasizing the need to thoughtfully implement and properly maintain them in urban environments. Furthermore, humans’ emotional experiences with green spaces may also reveal hidden or unexpected functions of those spaces. To confirm this lack of emphasis on emotions in BUP, we used Scopus to conduct a bibliometric analysis on relevant literature published within the last twenty years (2001–2021), ultimately collecting 589 relevant peer-reviewed articles. We then utilized VOSviewer (Centre for Science and Technology Studies, Leiden University, The Netherlands) to visualize our results and identify thematic, geographic, authorship/co-authorship, publication, and temporal trends. “Green space” appeared as our most frequently occurring keyword and scholars affiliated with institutions located within the United States, the United Kingdom and China were the top producers of relevant results. Our authorship analysis resulted in 67 different clusters and three major but isolated networks. Urban Forestry and Urban Greening was the most prevalent source of publication and 2019–2021 was the most prolific period of activity to date. While the goal of our review is to underscore the dearth of controlled, interdisciplinary research on the emotional components of BUP, we also uncovered additional key gaps in scholarship that could promote future avenues of inquiry. First, by focusing on the emotional value of green spaces, practitioners can ascribe them an intangible “human value” that could, in turn, generate more community-focused designs that provide access across socioeconomic, racial and age brackets. Second, an increase in scholarly representation from developing countries could help address the “human value” of green spaces not simply as a “first-world” phenomenon. Finally, a global focus on the emotional, human connections to green spaces may help scholars and practitioners alike mitigate the growing trend of green gentrification.
A Diary Study on Anticipated Leisure Time, Morning Recovery, and Employees’ Work Engagement
Authors: Seibel Sebastian , Volmer Judith
Published: September 2021

Recovery during yesterday’s leisure time is beneficial for morning recovery, and morning recovery fosters employees’ work engagement, a positive, motivational state associated with job performance. We extended existing research by assuming that both, morning recovery (considered a resource) and anticipated leisure time (considered an anticipated resource gain), relate to work engagement. Anticipated leisure time comprises two constructs: general anticipation of leisure time, which refers to employees’ cognitive evaluation of their entire upcoming leisure time, and pleasant anticipation of a planned leisure activity, which describes a positive affective reaction because of one specific, upcoming leisure activity. We suggested that employees with high pleasant anticipation generate more thoughts of a planned leisure activity (ToPLA), which may distract them from their work, reducing their work engagement. A diary study over five days showed that morning recovery and general anticipation of leisure time were positively related to work engagement. Furthermore, employees with higher pleasant anticipation of a planned leisure activity reported more ToPLA. In contrast to our expectations, neither pleasant anticipation nor ToPLA was related to work engagement. In sum, this study introduced anticipated leisure time as a novel antecedent of work engagement and demonstrated that anticipated resource gains are important for high work engagement.
Evolution of Culture on Patient Safety in the Clinical Setting of a Spanish Mutual Insurance Company: Observational Study between 2009 and 2017 Based on AHRQ Survey
Authors: Ulibarrena Miguel Ángel , Sainz de Vicuña Leire , García-Alonso Ignacio , Lledo Pablo , Gutiérrez Marta , Ulibarrena-García Asier , Echenagusia Víctor , Herrero de la Parte Borja
Published: September 2021

Background: Patient safety (PS) is a key factor in reducing or even eradicating adverse incidents and events. Many health organizations promote strategies to improve PS, while also pointing out the importance of measuring it. For more than eight years, our institution has developed strategies focused on improving PS-culture among our personnel. The goal of this paper is to analyze the PS-culture between the years 2009 and 2017. Methods: A cross-sectional survey focused on PS, and developed by the American Agency for Healthcare Research and Quality (AHRQ), was conducted in 2009 and in 2017 among all healthcare workers at Mutualia, anonymously and voluntarily. Results: The overall response rate was similar in both 2009 and 2017 (37.2% and 38.5%, respectively). The average rating obtained showed a significant improvement over the period (7.7 vs. 8.1; p < 0.05). Itemizing by question, the main strengths were found in management support, organizational learning and continuous improvement, and, especially, in teamwork. Regarding weaknesses, the two lowest scores were those which refer to the balance between clinical safety and workload and the freedom to question the decisions made by superiors. Conclusions: The results obtained from the PS-surveys show that the overall PS-culture in our institution has increased, suggesting that the strategies focused on the improvement of PS-culture were well adopted among our personnel. The overall score places Mutualia at similar levels to those reached by the AHRQ and Spanish National Health System.
Videoconference-Based Adapted Physical Exercise Training Is a Good and Safe Option for Seniors
Authors: Kuldavletova Olga , Pasquier Florane , Bigot Lucile , Langeard Antoine , Gauthier Antoine , Quarck Gaëlle
Published: September 2021

Videoconference-based adapted physical exercise combines the benefits of supervised exercise training with staying at home, when conventional training is inaccessible. However, exercising with the use of a screen can be considered an optokinetic stimulation, and could therefore induce changes in sensory processing, affecting postural stability. The objectives of this study were to compare the effectiveness of the training delivered Face-to-Face and by Videoconferencing in improving physical capacities of older adults, and to evaluate the possible effects of the Videoconference mode on the processing of sensory information that could affect postural control. Twenty eight older adults underwent the supervised exercise program for sixteen weeks either Face-to-Face or by Videoconference. Muscular strength of knee and ankle flexors and extensors, maximum oxygen uptake, postural stability and horizontal rotational vestibulo-ocular reflex were evaluated before and after the training. Both modes of training similarly increased the VO2 peak and strength of the motor muscles of lower limbs in all participants. The use of the Videoconference did not modify the vestibulo-ocular reflex in subjects or the importance of vision for postural control. Therefore, the Videoconference-based exercise training can be considered a safe and effective way to maintain good functional capacity in seniors.
Practice Effects, Test–Retest Reliability, and Minimal Detectable Change of the Ruff 2 and 7 Selective Attention Test in Patients with Schizophrenia
Authors: Lee Posen , Li Ping-Chia , Liu Chin-Hsuan , Lin Hung-Yu , Huang Chien-Yu , Hsieh Ching-Lin
Published: September 2021

Background: The Ruff 2 and 7 Selective Attention Test (RSAT) is designed to measure selective attention. It tests automatic detection speed (ADS), automatic detection errors (ADE), automatic detection accuracy (ADA), controlled search speed (CSS), controlled search errors (CSE), and controlled search accuracy (CSA). The purpose of this study was to examine the test–retest reliability, practice effect, and minimum detectable change (MDC) of the RSAT in patients with schizophrenia. Methods: A total of 101 patients with schizophrenia completed the RSAT twice at a 4-week interval. The intra-class correlation coefficient (ICC), paired t test, and effect size were used to examine the test–retest reliability and practice effect. The standard error of measurement (SEM) and MDC were calculated. Results: The difference scores between the two assessments were significant in all the indexes. The absolute effect sizes were 0.14 to 0.30. The ICCs of the RSAT ranged from 0.69 to 0.91. The MDC% in the indexes of ADS, ADA, and CSA of the RSAT were <30%. Conclusions: The RSAT is reliable for assessing selective attention in patients with schizophrenia. The RSAT has good to excellent test–retest reliability, a trivial to small practice effect, and indexes of ADS, ADA, and CSA, representing acceptable random measurement error.
Examining Wing Length–Abundance Relationships and Pyrethroid Resistance Mutations among Aedes albopictus in a Rapidly Growing Urban Area with Implications for Mosquito Surveillance and Control
Authors: Mundis Stephanie J. , Hamerlinck Gabriela , Stone Emily K. , Whiteman Ari , Delmelle Eric , Rapp Tyler , Dulin Michael , Ryan Sadie J.
Published: September 2021

Aedes albopictus is a cosmopolitan mosquito species capable of transmitting arboviruses such as dengue, chikungunya, and Zika. To control this and similar species, public and private entities often rely on pyrethroid insecticides. In this study, we screened Ae. albopictus collected from June to August 2017 in Mecklenburg County, a rapidly growing urban area of North Carolina, for mutations conferring pyrethroid resistance and examined spatiotemporal patterns of specimen size as measured by wing length, hypothesizing that size variation could be closely linked to local abundance, making this easily measured trait a useful surveillance proxy. The genetic screening results indicated that pyrethroid resistance alleles are not present in this population, meaning that this population is likely to be susceptible to this commonly used insecticide class. We detected no significant associations between size and abundance-related factors, indicating that wing-size is not a useful proxy for abundance, and thus not useful to surveillance in this capacity. However, mosquitoes collected in June were significantly larger than July or August, which may result from meteorological conditions, suggesting that short-term weather cues may modulate morphological traits, which could then affect local fecundity and virus transmission dynamics, as previously reported.
Bibliometric Analysis and Research Trend Forecast of Healthy Urban Planning for 40 Years (1981–2020)
Authors: Jia Bingyao , Chen Yuting , Wu Jing
Published: September 2021

The history of healthy city planning can be traced back to the beginning of the 19th century. Since the industrialization period, the harsh living conditions of cities and the outbreak of infectious diseases have promoted the coordinated development of urban planning and public health, and people have gradually realized the importance of urban design and planning to the health of residents. After searching keywords related to health city and urban planning, and excluding repeated, non-English, and unrelated papers, this work retrieved 2582 documents as the basic data (timespan is 1 January 1981–31 December 2020, retrieval time is 28 January 2021). Additionally, CiteSpace was used to analyze document co-citation, cooperation network, and topic co-occurrence. Subsequently, random forest algorithm was used to predict the probability of citation. Overall, this work found that the hot spots of healthy urban planning are physical activity, green space, urban green space, and mental health. It also shows the diversification of themes and the development trend of cross-fields in the field of healthy urban planning. In addition, the article found that two factors, namely, the average number of citations of the first author and whether the article belongs to the field of environmental research, have a great impact on the number of citations of the article. This work is of practical significance to relevant practitioners and researchers, because it provides guidance for hot topics and future research directions in the field of healthy urban planning.
First-Year Healthcare Resource Utilization Costs of Five Major Cancers in Japan
Authors: Watanabe Tomone , Goto Rei , Yamamoto Yoko , Ichinose Yuichi , Higashi Takahiro
Published: September 2021

Reports on the expenditure of cancer treatments per patient using comprehensive data remain unavailable in Japan. This study aimed to use Japan’s cancer registry data and health service utilization data for evaluating the disease-specific, per-patient costs of five major cancers—stomach, lung, colorectal, liver, and breast cancers. We used a database linking the 2017 data from a hospital-based cancer registry and the health service utilization data from the Diagnosis Procedure Combination survey. All patients who started their first treatment course at each hospital were included. The costs were calculated using the total volume of the health services provided and the unit fee information included in the data. We analyzed 304,698 patients. Lung cancer had the highest healthcare cost per-patient for the first year of diagnosis and the longest median hospitalization duration. Conversely, breast cancer showed the lowest cost and the shortest median hospitalization duration. However, in the first month after diagnosis, colorectal cancer showed the highest cost. Subsequently, the gaps between the costs of the five common cancers drastically diminished. The cancer type having the longest hospitalization duration had the highest overall healthcare resource utilization costs. This information is essential for care planning and research studies.
A Density-Peak-Based Clustering Method for Multiple Densities Dataset
Authors: Shi Zhicheng , Ma Ding , Yan Xue , Zhu Wei , Zhao Zhigang
Published: September 2021

Clustering methods in data mining are widely used to detect hotspots in many domains. They play an increasingly important role in the era of big data. As an advanced algorithm, the density peak clustering (DPC) algorithm is able to deal with arbitrary datasets, although it does not perform well when the dataset includes multiple densities. The parameter selection of cut-off distance dc is normally determined by users’ experience and could affect clustering result. In this study, a density-peak-based clustering method is proposed to detect clusters from datasets with multiple densities and shapes. Two improvements are made regarding the limitations of existing clustering methods. First, DPC finds it difficult to detect clusters in a dataset with multiple densities. Each cluster has a unique shape and the interior includes different densities. This method adopts a step by step merging approach to solve the problem. Second, high densities of points can automatically be selected without manual participation, which is more efficient than the existing methods, which require user-specified parameters. According to experimental results, the clustering method can be applied to various datasets and performs better than traditional methods and DPC.