bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics of mutual funds with extreme performance
Authors: Berkowitz Jason P. , Schorno Patrick J. , Shapiro Dmitry A.
Published: April 2017

We focus on mutual fund characteristics associated with periods of extreme performance. We find that funds with either positive (hot‐hand) or negative (icy‐hand) persistence tend to have portfolio similarities consistent with riskier positions: compared to no‐streak funds, they hold fewer stocks, invest more in top ten holdings, and have a higher portfolio beta. Also both hot‐hand and icy‐hand funds have significantly higher asset turnover than benchmark funds. Icy‐hand funds tend to be more extreme with riskier positions and asset turnover than hot‐hand funds. At the same time, icy‐hand (hot‐hand) funds tend to have larger (smaller) management teams, and are less (more) likely to be managed by one person. Finally, we do not observe many funds changing their management teams either before or after extreme performance. That is, we find no evidence that the beginning of an extreme performance period is associated with changes in management or that it induces changes in management.
Influence of selenium source on the performance, feathering and meat quality of broilers
Authors: Ravindran V. , Elliott S.
Published: April 2017

The following trial was conducted to investigate the effects of Se source (inorganic sodium selenite (SS) versus organic use Sel-Plex® (SP; Alltech Inc, Nicholasville, KY, USA)) on the performance, feathering and meat quality of 900, one-day-old male broilers over a 42 day growing period. Pens (n = 20) were randomly assigned to either: Diet A (no Se; negative control), Diet B as for diet A plus 0.3 mg/kg SS (positive control), Diet C as for diet A plus 0.2 mg/kg SP, Diet D as for diet A plus 0.3 mg/kg SP and Diet E as for diet A plus 0.4 mg/kg SP. From day 1 to 28, significant (P < 0.05) treatment effects were seen for feed intake and FCR, with values for the negative control being higher than for the diets containing Se. The best FCR was recorded for the diet containing 0.4 mg/kg SP. Breast meat yield for birds fed the negative control were lower than those fed selenite or SP supplemented diets (P < 0.05). Feather measurements on d 14, 28 and 42 of age showed that, although scores became poorer with age (4.9 at 14 d, 4.6 at 28 d and 3.6 at 42 d), they were unaffected (P > 0.05) by dietary Se inclusion. Numeric trends in favour of SP were seen in cooking losses in meat chilled for 24 hours and seven days. Cooking losses in meat frozen for seven days were significantly influenced by Se inclusion, whereby values for birds fed 0.3 and 0.4 mg/kg SP were significantly lower than values for birds fed inorganic selenite (P < 0.05). Tissue Se concentrations were highest for the SP diets. Meat oxidation from the birds fed SP was lower than for the birds fed no Se or SS. The results demonstrated that SP may be more advantageous in improving certain variables of performance and meat quality compared to inorganic sources of Se.
Transient lift force on a blade during cutting of a vortex with non-zero axial flow
Authors: Saunders D. Curtis , Marshall Jeffrey S.
Published: April 2017

The problem of orthogonal penetration of a blade into the core of a vortex with non-zero axial flow was studied using a combination of scaling theory, a heuristic plug-flow model and full Navier–Stokes simulations. The particular focus of this paper was to understand the mechanics of the transient lift force that occurs during the initial penetration of the blade leading edge into the vortex core, and the relationship of this transient force to the steady-state lift force that develops due to the difference in vortex core radius over the blade surface. The three modelling approaches all lead to the conclusion that the maximum value of the lift coefficient for the transient blade penetration force is proportional to the impact parameter and inversely proportional to the axial flow parameter. This observation is used to develop a simple expression that collapses the predictions of the full Navier–Stokes simulations for lift coefficient over a wide range of parameter values.
A diverse assemblage of Permian echinoids (Echinodermata, Echinoidea) and implications for character evolution in early crown group echinoids
Authors: Thompson Jeffrey R. , Petsios Elizabeth , Bottjer David J.
Published: April 2017

The Permian is regarded as one of the most crucial intervals during echinoid evolution because crown group echinoids are first widely known from the Permian. New faunas provide important information regarding the diversity of echinoids during this significant interval as well as the morphological characterization of the earliest crown group and latest stem group echinoids. A new fauna from the Capitanian Lamar Member of the Bell Canyon Formation in the Guadalupe Mountains of West Texas comprises at least three new taxa, includingEotiaris guadalupensisThompson n. sp. an indeterminate archaeocidarid, andPronechinus? sp. All specimens represented are silicified and known from disarticulated or semiarticulated interambulacral and ambulacral plates and spines. This assemblage is one of the most diverse echinoid assemblages known from the Permian and, as such, informs the paleoecological setting in which the earliest crown group echinoids lived. This new fauna indicates that crown group echinoids occupied the same environments as stem group echinoids of the Archaeocidaridae and Proterocidaridae. Furthermore, the echinoids described herein begin to elucidate the order of character transitions that likely took place between stem group and crown group echinoids. At least one of the morphological innovations once thought to be characteristic of early crown group echinoids, crenulate tubercles, was in fact widespread in a number of stem group taxa from the Permian as well. Crenulate tubercles are reported from two taxa, and putative cidaroid style U-shaped teeth are present in the fauna. The presence of crenulate tubercles in the archaeocidarid indicates that crenulate tubercles were present in stem group echinoids, and thus the evolution of this character likely preceded the evolution of many of the synapomorphies that define the echinoid crown group.
A Special Chamber of the International Court of Justice — An Alternative to Ad Hoc Arbitration
Authors: Hyde James N.
Published: April 2017

Litigation of contentious cases before the International Court of Justice has in some instances been a lengthy and comparatively expensive procedure. However, it is not necessarily the Court or its procedure that produces this situation, because governments parties to litigation sometimes feel it is important to retain a number of advocates to plead, and they agree on comparatively long periods for the preparation of written pleadings. Comparing this procedure with ad hoc arbitration before a referee and two arbitrators, the latter looks comparatively swift and inexpensive. However, there are as yet unused possibilities for the International Court to adjudicate cases on a basis comparable in time and expense to ad hoc arbitration. The use of the Court for what might be less important cases would also contribute to its institutional development.
A. B. A. National Institute on Marine Resources
Authors: Krueger Robert B.
Published: April 2017

The first meeting of the A.B.A. National Institute on Marine Resources, sponsored by the Section of Natural Resources Law, was held in Long Beach, California, June 7-10, 1967. The program included the presentation of papers, panel discussions, and questions from the audience dealing with the following topics : United States policy regarding marine resources ; the administration of marine resources underlying the high seas; zones of national interest—a discussion of the need for revision of the Geneva Conventions; the administration of laws for the exploitation of offshore minerals in the United States; and the technological aspects of exploiting marine resources.
A New Initiative In Asian Legal Development—Lawasia
Authors: Burn Barbara B.
Published: April 2017

Legal development in the developing countries is at the same time one of the most urgent needs for modernization and one of the most delicate fields in which non-national organizations, private as well as public, can render assistance.

A comprehensive, unified, and depersonalized body of law, a welltrained and adequate legal profession, and an efficient system of judicial administration are necessary to the mobilization of human resources for national development, to the safeguarding of human rights, and to the orderly and impartial operation of government in the developing (and developed) countries. To participate fully in the international community and share in the benefits of international intercourse, economic and political, the developing countries require carefully developed bodies of law relating to commerce and banking, trade and investment, and the whole field of foreign relations.
Sunken Soviet Submarines and Central Intelligence: Laws of Property and the Agency
Authors: Rubin Alfred P.
Published: April 2017

In a series of newspaper columns and stories beginning March 19, 1975 the American public was told apparently correctly about the partial success of the Central Intelligence Agency in raising a Soviet submarine, its equipment, and dead crew from the Pacific Ocean floor. The location of the pertinent activities was reported to be well beyond any state's claim to territorial waters, continental shelves, contiguous zones, or other asserted inhibiting zones. The CIA vessel, The Glomar Explorer, was disguised as a commercially operated oceanographic research vessel. No international legal implications seem to have been perceived by the newspapers in the American intelligence activities.
Remarks by Robert K. Goldman
Authors: Goldman Robert K.
Published: April 2017

Since Mr. MacCrate has traced the events in Chile which have lead Braden to institute legal proceedings in Europe to recover its allegedly confiscated copper and their proceeds, I think it important to state the legal theory upon which the company is basing its actions. Braden is asserting ownership rights in copper and other products derived from E1 Teniente mine on the ground that the constitutionally mandated procedures for valuating El Teniente’s assets, as applied, fell below the minimum standards required by international law and thereby resulted in the confiscation of Braden’s equity position in El Teniente. Accordingly, the Company argues that any rights acquired by Chile by virture of the nationalization are without legal effect.
Remarks by Morton Kaplan
Authors: Kaplan Morton
Published: April 2017

Less than a generation ago international relations textbooks either referred to the international system as a realm of anarchy or applied to it global generalizations such as the balance of power. That the number of major states in the system, their economic and military potential, their alliance patterns, and so forth might affect the resort to force and the results of such resort was largely foreign to analysis.
Remarks by Herbert Scoville
Authors: Scoville Herbert
Published: April 2017

In speaking about arms control negotiations in a multipolar world, it is necessary to bear in mind that we are not really in a multipolar world right now. But perhaps we are starting toward one, at least as far as nuclear power is concerned. Britain, France, and China possess only relatively small nuclear forces at present but they will grow in time and eventually will have to be taken into consideration at least in arms control negotiations involving nuclear weapons. France and Britain at the present do have a nuclear deterrent force which would deter an attack as far as the Soviets are concerned. The status of the Chinese nuclear force is very much more uncertain. It is possible that they now possess a very limited deterrent to an attack by the Soviet Union. Certainly there is no question that at the present time they do not have any means by which they can threaten, even in retaliation, a nuclear attack against the United States. As a consequence, the Chinese do not provide any direct threat to us and we can go ahead and negotiate agreements with the Soviet Union without any real consideration of Chinese participation. One need not conclude from the growing Chinese nuclear power that they must necessarily be brought into the SALT negotiations in the near future.
Remarks by Frits Kalshoven
Authors: Kalshoven Frits
Published: April 2017

The two highly interesting and stimulating presentations we have just heard provide us with an excellent survey of a number of important aspects of the law of armed conflicts, both as it stands today and from the point of view of lex ferenda. As George Aldrich correctly predicted, although the program for this meeting promised “conflicting views,” there appears to be much common ground between him and Hans Blix, much more than in fact has been apparent of late between the U.S. and Swedish Governments on certain other (though related) matters.
The World Court—An Inside View
Authors: Dillard Judge Hardy C.
Published: April 2017

Mr. Chairman, President Rogers, Professor McDougal, Judge Hack-worth, honored guests, ladies and gentlemen: When Steve Schwehel called me up over long distance I was peacefully having supper at the Promenade Hotel in The Hague. He asked me if I would quickly pinch-hit for Manfred Lachs, who had accepted but was laid low by illness. I accepted in a mood of exuberant indiscretion. I did not know then that my good friend, Myres McDougal, would steal most of the time theoretically allocated for what is called the major address of the evening. However, I forgive him because of his gracious allusion to Mrs. Dillard. This is the kind of thing we Southerners indulge in with the grace and respect for the amenities for which we are renowned.
Photography as Event: Power, the Kodak Camera, and Territoriality in Early Twentieth-Century Tibet
Authors: Koole Simeon
Published: April 2017

This article rethinks the nature of power and its relation to territory in the photographic event. Focusing on thousands of photographs taken during the British Younghusband Expedition to Lhasa between 1903 and 1904, it reorients understandings of photography as either reproducing or enabling the “negotiation” or contestation of power inequalities between participants. It shows how, in the transitory relations between Tibetans, Chinese, and Britons during and after photographic events, photography acted as a means by which participants constituted themselves as responsible agents—as capable of responding and as “accountable”—in relation to one another and to Tibet as a political entity. Whether in photographs of Tibetans protesting British looting or of their “reading” periodicals containing photographs of themselves, photography, especially Kodak photography, proposed potential new ways of being politically “Tibetan” at a time when the meaning of Tibet as a territory was especially indeterminate. This article therefore examines how the shifting territorial meaning of Tibet, transformed by an ascendant Dalai Lama, weakening Qing empire, and Anglo-Russian competition, converged with transformations in the means of visually reflecting upon it. If photography entailed always-indeterminate power relations through which participants constituted themselves in relation to Tibet, then it also compels our own rethinking of Tibet itself as an event contingent on every event of photography, rather than pre-existing or “constructed” by it.
Determining Emotions and the Burden of Proof in Investigative Commissions to Palestine
Authors: Allen Lori A.
Published: April 2017

The conflict in Palestine has been the subject of numerous international investigative commissions over the past century. These have been dispatched by governments to determine the causes of violent conflicts and how to resolve them. Commissions both produce and reflect political epistemologies, the social processes and categories by which proof and evidence are produced and mobilized in political claim-making. Using archival and ethnographic sources, my analysis focuses on three investigative commissions: the King-Crane (1919), Anglo-American (1946), and Mitchell (2001) commissions. They reveal how “reading affect” has been a diagnostic of political worthiness. Through these investigations, Western colonial agents and “the international community” have given Palestinians false hope that discourse and reason were the appropriate and effective mode of politics. Rather than simply reason, however, what each required was maintenance of an impossible balance between the rational and the emotional. This essay explores the ways that affect as a diagnostic of political worthiness has worked as a technology of rule in imperial orders, and has served as an unspoken legitimating mechanism of domination.
The Bengali Pharaoh: Upper-Caste Aryanism, Pan-Egyptianism, and the Contested History of Biometric Nationalism in Twentieth-Century Bengal
Authors: Mukharji Projit Bihari
Published: April 2017

Extant South Asian histories of race, and more specifically biometrics, focus almost exclusively upon the colonial era and especially the nineteenth century. Yet an increasing number of ethnographic accounts observe that Indian scientists have enthusiastically embraced the resurgent raciology engendered by genomic research into human variation. What is sorely lacking is a historical account of how raciology fared in the late colonial and early postcolonial periods, roughly the period between the decline of craniometry and the rise of genomics. It is this history that I explore in this article. I argue that anthropometry, far from being a purely colonial science, was adopted by Indian nationalists quite early on. Various distinctive shades of biometric nationalism publicly competed from the 1920s onward. To counter any sense that biometric nationalism was teleologically inevitable, I contrast it with a radical alternative called “craftology” that emerged on the margins of formal academia amongst scholars practicing what I call “vernacular anthropology.” Craftology and biometric nationalism continued to compete, contrast, and selectively entangle with each other until almost the end of the twentieth century.
C. A. Bayly and the Question of Indian Political Thought
Authors: SARTORI ANDREW
Published: April 2017

This article reflects on C. A. Bayly's legacy, with particular attention to his late turn to the history of Indian political thought. It highlights the force of his attempt to approach South Asian history with a keen eye to its specificity without correlatively compromising his attention to questions of comparability. It also highlights some of the conceptual and methodological dilemmas with which his final work confronts us.
The IWW in Turin: “Militant History,” Workers’ Struggle, and the Crisis of Fordism in 1970s Italy
Authors: Pizzolato Nicola
Published: April 2017

This article analyses how in the 1970s a segment of Italian radical activists belonging to the tradition of operaismo (workerism) appropriated and interrogated the history of the International Workers of the World (IWW) using it as a tool of political intervention in the Italian context. Following the upheaval of the ‘Hot Autumn’, the IWW provided to the Italians an inspiring comparison with a militant labour organisation in times of changing composition of the working class and of transformation of the organisation of production. The importance of this political use of the past lies in the way it illuminates the particular context in which these activists operated. In the course of the 1970s, Italian radicals responded to the normalization of industrial relations by joining groups that endorsed a political line tinted with Leninism and advocated a revolution led by a vanguard of militants. This was in contrast to the tenets of shopfloor-centered strategy and grassroots and shopfloor participation typical of operaismo. The – eventually – failed attempt of the ‘militant historians’ to revive, through their distinctive interpretation of the IWW, that political tradition sheds light on the success of the backlash against shopfloor working class militancy at the end of the decade, when vanguard groups had become marginal in the factories and reformist unions lacked a political clout to oppose company restructuring and relocation. This article is based on articles, memoirs and interviews that are evidence of the politically-driven debate about the IWW among Italian radicals. It improves on the existing historiography of the Italian labour movement by resisting its teleological impulse to explain the backlash on the 1980s as an inevitable outcome. It also contributes to the burgeoning transnational labor historiography; it challenges methodological nationalism in the study of workers’ insurgency by charting the influence of US history far beyond its borders and across time, adopting a transnational approach that is, unusually, both geographical and a diachronic. This story tells us more about Italian history than it does about American history, but it is testimony to a far reaching influence of American history and to entanglements that crossed borders through the work of the activists, scholars, and translators who acted as transnational vehicles of ideas and political practices.
Coolie Alibis: Seizing Gold from Chinese Miners in New South Wales
Authors: Loy-Wilson Sophie
Published: April 2017

This article examines debates over Chinese indentured labor in the Australasian colonies at the height of the gold rushes. It does so through the testimony of Chinese gold miners who protested the seizure of their gold by customs officials in Sydney Harbour. As a result of these protests, a “New South Wales Select Committee into the Seizure of Gold from Chinese Miners” was established in 1857 to investigate customs law and “coolie” rights. The findings of this committee uncovered Chinese and white settler memories over failed coolie transportation schemes, revealing the ways in which the legacies of coolie migration continued to shape understandings in the Australian colonies of law, labor rights, and fair taxation well after the cessation of such schemes in the 1840s. The archive of Chinese grievance against the colonial state, preserved in testimonies given to the select committee, reveal the long shadow of slavery in the British Empire, the complexities of multiracial communities, and the role of law and legal institutions in shaping both.
Combining XRD and XRF analysis in one Rietveld-like fitting
Authors: Bortolotti M. , Lutterotti L. , Pepponi G.
Published: April 2017

X-ray diffraction (XRD) and X-ray fluorescence (XRF) are widely used analytical techniques for materials characterization; the information they provide can be considered complementary, as the former is mostly used to obtain crystallographic information and analyze phase content, whereas the latter is sensitive to elemental composition. Many researchers and technologists working in a variety of application fields already use them together in some sort of a “combined” approach, by separately performing XRD and XRF data collection and analysis on the same sample and then comparing the analytical results obtained to integrate and complement the respective analytical information. In this work, we propose a true combined approach to merge both XRD and XRF data acquisition and analysis. Custom analytical X-ray instrumentation has been developed to perform the simultaneous data acquisition, by using a single X-ray source and dedicated detectors to collect the diffracted and fluorescent X-ray photons from the same sample volume. Additionally, a combined XRD/XRF data analysis methodology has been implemented by extending Rietveld based code to incorporate the full pattern fitting of XRF spectra starting from the phases instead of a simple matrix elemental composition. We report two analytical examples from different application fields to better illustrate the capabilities of the proposed approach.
Languages flex cultural thinking
Authors: ELLIS CERI , THIERRY GUILLAUME , VAUGHAN-EVANS AWEL , JONES MANON WYN
Published: April 2017

Recent studies have revealed remarkable interactions between language and emotion. Here, we show that such interactions influence judgments made regarding cultural information. Balanced Welsh–English bilinguals categorized statements about their native Welsh culture as true or false. Whilst participants categorized positive statements as true when they were true, they were biased towards categorizing them as true also when they were false, irrespective of the language in which they read them. Surprisingly, participants were unbiased when categorizing negative statements presented in their native language Welsh, but showed a reverse bias - categorizing sentences as false, even when they were true - for negative statements when they read them in English. The locus of this behavior originated from online semantic evaluation of the statements, shown in corresponding modulations of the N400 peak of event-related brain potentials. These findings suggest that bilinguals perceive and react to cultural information in a language-dependent fashion.
Adding another dimension to plan evaluation: visualising the dose–volume histogram band in head and neck radiotherapy and exploring its utility
Authors: Samanta S. , Balukrishna S. , Rafic K.M. , Timothy Peace B.S. , Singh I.R.R. , Pavamani S.P.
Published: April 2017

Background

To introduce a method to generate a ‘dose–volume histogram (DVH) band’ for plan evaluation of photon therapy and explore its various potentials.

Materials and methods

Intensity-modulated radiotherapy (IMRT) plans for head and neck cancer patients were analysed, retrospectively, for setup errors noted during treatment. From the maximum observed random errors, absolute displacement was calculated using Euclidian formula. The original plan with same beam parameters and leaf sequence were used to generate six plans with shifts applied in three axes in six directions. The DVH curves from these six plans were superimposed to form the DVH band. Plans were reviewed with set tolerance criteria.

Results

Method to generate and visualise DVH band was developed. DVH bands were created for 20 patients with head and neck cancer who underwent treatment with IMRT. It was found that seven out these 20 plans were rejected as they crossed the set tolerance criteria using DVH band as an evaluation tool.

Conclusions

DVH band in photon therapy can help the clinician visualise the impact of setup errors at planning and may help select the plan with lesser influence of setup errors over another.
The Police Use of Social Media: Transformation or Normalisation?
Authors: Bullock Karen
Published: April 2017

There has been optimism that social media will facilitate citizen participation and transform the communication strategies of public organisations. Drawing on a case study of the public police in England, this article considers whether social media are transforming or normalising communications. Arguing that social media have not yet served to facilitate interaction between constabularies and citizens in the ways that have been proposed and desired, the article considers factors that structure the transformative potential of social media. It is argued that the uses of social media are mediated by the existing organisational and occupational concerns of the police. This article reveals how an interplay of organisational, technological and individual and cultural dynamics come together to shape how social media are used in constabularies. Embedding social media into police communications is challenging and the technology itself will not bring about the organisational and cultural changes needed to transform police–citizen engagement.
Critical Networks
Authors: Watt Paul , Collins Sarah
Published: April 2017

This article examines the idea of ‘Critical Networks’ as a way of studying the relational structures that shaped music criticism in the long nineteenth century. We argue that the personal, institutional and international networks that supported the dissemination of critical ideas about music are worthy of study in themselves, as they can yield insights beyond prevailing methodologies that centre on individual cases.

Focusing on the institutional culture of music criticism means looking beyond the work of individual critics and the content or influence of their views, towards the structures that determined the authoritativeness of those views and the impact of these structures in shaping the operation of critical discourse on music at the time. Examining these networks and how they operated around particular periodicals, tracing transnational exchanges of both ideas and critics, and uncovering the various ideological alliances that were forged or contested within critical networks, can not only provide a thicker context for our understanding of historical ideas about music, but it can also challenge current views about the history of our discipline and the kinds of structures that condition our own ideas about music and music history.
One concept, many interpretations: the media’s causal roles in political agenda-setting processes
Authors: Sevenans Julie
Published: April 2017

While political agenda-setting scholars agree that the news media matter when it comes to agenda setting, surprisingly, there is no consensus on the exact role these media play in the agenda-setting process. In particular, causal interpretations of the media’s role are diverse. This contribution focuses on this ambiguity in the agenda-setting field. First, it outlines the main reasons for the disagreement, both on a theoretical and on an empirical level. Second, it develops a theoretical model that helps to specify what role the news media play under various circumstances. Overall, the paper strongly encourages scholars to reflect more on causal mechanisms in political agenda-setting work, and makes a first attempt at facilitating the interpretation of extant and future findings.
The health outcomes of human offspring conceived by assisted reproductive technologies (ART)
Authors: Chen M. , Heilbronn L. K.
Published: April 2017

Concerns have been raised about the health and development of children conceived by assisted reproductive technologies (ART) since 1978. Controversially, ART has been linked with adverse obstetric and perinatal outcomes, an increased risk of birth defects, cancers, and growth and development disorders. Emerging evidence suggests that ART treatment may also predispose individuals to an increased risk of chronic ageing related diseases such as obesity, type 2 diabetes and cardiovascular disease. This review will summarize the available evidence on the short-term and long-term health outcomes of ART singletons, as multiple pregnancies after multiple embryos transfer, are associated with low birth weight and preterm delivery, which can separately increase risk of adverse postnatal outcomes, and impact long-term health. We will also examine the potential factors that may contribute to these health risks, and discuss underlying mechanisms, including epigenetic changes that may occur during the preimplantation period and reprogram development in utero, and adult health, later in life. Lastly, this review will consider the future directions with the view to optimize the long-term health of ART children.
Repoliticizing the Ancient Greek City, Thirty Years Later
Authors: Azoulay Vincent
Published: April 2017

Abstracts

Thirty years after Nicole Loraux published her 1986 article inL’Homme, this study revisits the question of political experience in the ancient Greek world. Its aim is to demonstrate the importance of the two definitions of the term “politics” as conceived by the Ancient Greeks. On the one hand,the politicalwas conceived as an ensemble of activities with no specific institutional substance or form, a sphere of action that has no direct equivalent in the modern state, but rather relates to very varied experiences and practices undertaken in the context of conflict. On the other hand,politicswas understood not only as organized access to different institutions, but also as the way in which a community structured and defined itself. Taking the Athenian crisis of 404-403 BCE as a case study, in particular the speech of Cleocritus preserved in Xenophon’sHellenica, this paper proposes a new way of thinking about this dual expression of collective life. Far from the reconciliatory reading of Cleocritus’ speech proposed by Loraux, his appeal for harmony bears witness, in the turmoil and tension of events, to the way thatpolitics(in the institutional sense) was sidelined to the exclusive benefit ofthe politicaland the collective practices associated with it. In conclusion, this case study opens up a more general consideration of the meaning of the “event” and its epistemological significance. By considering the crisis of 404-403 BCE at the heart of the “regimes of historicity” that characterized the history of Athens between the fifth and fourth centuries BCE, this article aims to provide a clearer articulation of the foundational moments and established functioning of Greek democracy.
The Single Body of the City: Public Slaves and the Question of the Greek State
Authors: Ismard Paulin
Published: April 2017

Abstracts

Public slavery was an institution common to most Greek cities during the Classical and Hellenistic periods. Whether they worked on the city’s major construction sites, performed minor duties in its civic administration or filled the ranks of its police force (the famous Scythian archers of classical Athens), public slaves may be said to have constituted the first public servants known to Greek cities. Studying them from this perspective can shed new light on the long-running debate about the degree to which thepolisfunctioned as a state. Direct democracy, in the Classical Athenian sense, implied that all political prerogatives be held by the citizens themselves, and not by any kind of state apparatus. The decision to delegate administrative tasks to slaves can thus be understood as a “resistance” (as defined by the French anthropologist Pierre Clastres) on the part of the civic society to the development of this apparatus.
Capital, Social Reproduction, and the Rise of Inequality
Authors: Spire Alexis
Published: April 2017

Thomas Piketty’s book has the great merit of implementing a global analysis of inequality that compares countries and periods. However, he adopts a definition of social class that overlooks the importance of cultural capital. Furthermore, the role of social movements is relatively marginalized in his account, which also focuses on fiscal tools to the detriment of other forms of regulation. Nonetheless, this innovative and important book opens up new avenues of research in the field of political sociology.
Chronological Depths and the Longue Durée
Authors: Lamouroux Christian
Published: April 2017

This short contribution seeks to place David Armitage and Jo Guldi’s article within a broader historiographical context, enlarged to include the history of China. From the outset, Fernand Braudel was careful to link his vision of the longue durée with the new “area studies” exploring international cultures. By studying social and economic history and more generally by using approaches drawn from the social sciences, European and American specialists of China have deconstructed the overly longue durée of Chinese history and shed light on its dynamism, previously repressed and concealed by the notion of a so-called “civilization.” This process facilitated a successful specialization, which can today be supported by the “big data” being compiled in circles close to the two authors.
Ecological Mowing: An Option for Sustainable Weed Management in Young Citrus Orchards
Authors: Martinelli Rodrigo , Monquero Patrícia A. , Fontanetti Anastácia , Conceição Patrícia M. , Azevedo Fernando A.
Published: April 2017

The citrus yield in Brazil is not ranked among the best in the world, potentially due to inadequate management by citrus growers. The low adoption of conservation agriculture (CA) techniques and the improper application of herbicides are also well-known problems. Thus, this study evaluated the use of CA techniques, and twoUrochloaspecies (ruzi grass and signal grass) were used as cover crops. Two different types of mowers (ecological, EM; conventional, CM) launched the mowed biomass into different positions within a young Tahiti acid lime orchard (up to four years old). In addition, the integration of glyphosate into this management system was evaluated, with (GLY) and without (NO GLY) glyphosate application. This experiment was conducted across three growing seasons (2011-2014), in Mogi Mirim, São Paulo State, Brazil. The cover crop biomass yields and the effects of the mowing treatments, weed density, vegetative growth and fruit yields of the Tahiti acid lime trees were evaluated. In terms of major results, signal grass produced higher biomass yield values (up to 64%) than ruzi grass; EM promoted higher mowed biomass values in the intra-row (up to 5.1 ton ha−1, 9.0 times higher than CM), and a higher canopy volume (up to 33% than CM). These results were enhanced when ruzi grass was associated with the EM (56% lower weed density; 126% higher fruit yield than CM) and with GLY (52% higher fruit yield than NO GLY); and EM with GLY (43% lesser weed density and 107% higher fruit yield than NO GLY). Overall, ruzi grass was a good cover crop because it provided less competition for the citrus trees, EM provided a mulch layer in the intra-row of the citrus trees, and associated with GLY, these approaches could provide options for an integrated and more sustainable weed management, primarily for young Tahiti acid lime orchards.
Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Authors: Tang HaoRan , Leung Leo , Saturno Grazia , Viros Amaya , Smith Duncan , Di Leva Gianpiero , Morrison Eamonn , Niculescu-Duvaz Dan , Lopes Filipa , Johnson Louise , Dhomen Nathalie , Springer Caroline , Marais Richard
Published: April 2017

Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the epidermal growth factor receptor (EGFR) to drive tumour progression. We show that LOX regulates EGFR by suppressing TGFβ1 signalling through the secreted protease HTRA1. This increases the expression of Matrilin2 (MATN2), an EGF-like domain-containing protein that traps EGFR at the cell surface to facilitate its activation by EGF. We describe a pharmacological inhibitor of LOX, CCT365623, which disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumour cells in vivo. Thus, we show that LOX regulates EGFR cell surface retention to drive tumour progression, and we validate the therapeutic potential of inhibiting this pathway with the small molecule inhibitor CCT365623.
Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
Authors: Zhao Xiaohong , Lwin Tint , Silva Ariosto , Shah Bijal , Tao Jiangchuan , Fang Bin , Zhang Liang , Fu Kai , Bi Chengfeng , Li Jiannong , Jiang Huijuan , Meads Mark B. , Jacobson Timothy , Silva Maria , Distler Allison , Darville Lancia , Zhang Ling , Han Ying , Rebatchouk Dmitri , Di Liberto Maurizio , Moscinski Lynn C. , Koomen John M. , Dalton William S. , Shain Kenneth H. , Wang Michael , Sotomayor Eduardo , Tao Jianguo
Published: April 2017

The novel Bruton’s tyrosine kinase inhibitor ibrutinib has demonstrated high response rates in B-cell lymphomas; however, a growing number of ibrutinib-treated patients relapse with resistance and fulminant progression. Using chemical proteomics and an organotypic cell-based drug screening assay, we determine the functional role of the tumour microenvironment (TME) in ibrutinib activity and acquired ibrutinib resistance. We demonstrate that MCL cells develop ibrutinib resistance through evolutionary processes driven by dynamic feedback between MCL cells and TME, leading to kinome adaptive reprogramming, bypassing the effect of ibrutinib and reciprocal activation of PI3K-AKT-mTOR and integrin-β1 signalling. Combinatorial disruption of B-cell receptor signalling and PI3K-AKT-mTOR axis leads to release of MCL cells from TME, reversal of drug resistance and enhanced anti-MCL activity in MCL patient samples and patient-derived xenograft models. This study unifies TME-mediated de novo and acquired drug resistance mechanisms and provides a novel combination therapeutic strategy against MCL and other B-cell malignancies.
Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer
Authors: Solzak Jeffrey P. , Atale Rutuja V. , Hancock Bradley A. , Sinn Anthony L. , Pollok Karen E. , Jones David R. , Radovich Milan
Published: April 2017

Triple negative breast cancer accounts for 15–20% of all breast cancer cases, but despite its lower incidence, contributes to a disproportionately higher rate of mortality. As there are currently no Food and Drug Administration-approved targeted agents for triple negative breast cancer, we embarked on a genomic-guided effort to identify novel targeted modalities. Analyses by our group and The Cancer Genome Atlas have identified activation of the PI3K-pathway in the majority of triple negative breast cancers. As single agent therapy is commonly subject to resistance, we investigated the use of combination therapy against compensatory pathways. Herein, we demonstrate that pan-PI3K inhibition in triple negative breast cancers results in marked activation of the Wnt-pathway. Using the combination of two inhibitors currently in clinical trial as single agents, buparlisib(pan-PI3K) and WNT974(WNT-pathway), we demonstrate significant in vitro and in vivo synergy against triple negative breast cancer cell lines and xenografts. Taken together, these observations provide a strong rationale for testing dual targeting of the PI3K and WNT-pathways in clinical trials.
Adaptive quantum state tomography via linear regression estimation: Theory and two-qubit experiment
Authors: Qi Bo , Hou Zhibo , Wang Yuanlong , Dong Daoyi , Zhong Han-Sen , Li Li , Xiang Guo-Yong , Wiseman Howard M. , Li Chuan-Feng , Guo Guang-Can
Published: April 2017

Adaptive techniques have great potential for wide application in enhancing the precision of quantum parameter estimation. We present an adaptive quantum state tomography protocol for finite dimensional quantum systems and experimentally implement the adaptive tomography protocol on two-qubit systems. In this adaptive quantum state tomography protocol, an adaptive measurement strategy and a recursive linear regression estimation algorithm are performed. Numerical results show that our adaptive quantum state tomography protocol can outperform tomography protocols using mutually unbiased bases and the two-stage mutually unbiased bases adaptive strategy, even with the simplest product measurements. When nonlocal measurements are available, our adaptive quantum state tomography can beat the Gill–Massar bound for a wide range of quantum states with a modest number of copies. We use only the simplest product measurements to implement two-qubit tomography experiments. In the experiments, we use error-compensation techniques to tackle systematic error due to misalignments and imperfection of wave plates, and achieve about a 100-fold reduction of the systematic error. The experimental results demonstrate that the improvement of adaptive quantum state tomography over nonadaptive tomography is significant for states with a high level of purity. Our results also show that this adaptive tomography method is particularly effective for the reconstruction of maximally entangled states, which are important resources in quantum information.
In vitro developmental ability of ovine oocytes following intracytoplasmic injection with freeze-dried spermatozoa
Authors: Olaciregui Maite , Luño Victoria , Domingo Paula , González Noelia , Gil Lydia
Published: April 2017

Freeze-drying (FD) is a new and alternative method to preserve spermatozoa in refrigeration or at room temperature. Suitable protection is required to maintain the sperm DNA integrity during the whole process and storage. The aim of this study was to examine the effect of rosmarinic acid and storage temperature on the DNA integrity of freeze-dried ram sperm. In addition, we evaluated the in vitro developmental ability to the blastocyst stage of oocytes injected with freeze-dried sperm. Ram sperm was freeze-dried in basic medium and in this medium supplemented with 105 µM rosmarinic acid. The vials were stored for 1 year at 4 °C and at room temperature. Frozen sperm was used as control. After rehydration, sperm DNA damage was evaluated, observing that the percentage of spermatozoa with DNA damage decreased significantly in the presence of rosmarinic acid, without differences between the two storage temperatures. Moreover, no differences were observed between the freeze-dried group and the frozen-thawed group in terms of blastocyst formation rate. We proved for the first time that ovine spermatozoa can be lyophilized effectively, stored at room temperature for long term, reconstituted and further injected into oocytes with initial embryo development.
3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells
Authors: Parlato Stefania , De Ninno Adele , Molfetta Rosa , Toschi Elena , Salerno Debora , Mencattini Arianna , Romagnoli Giulia , Fragale Alessandra , Roccazzello Lorenzo , Buoncervello Maria , Canini Irene , Bentivegna Enrico , Falchi Mario , Bertani Francesca Romana , Gerardino Annamaria , Martinelli Eugenio , Natale Corrado , Paolini Rossella , Businaro Luca , Gabriele Lucia
Published: April 2017

Immunotherapy efficacy relies on the crosstalk within the tumor microenvironment between cancer and dendritic cells (DCs) resulting in the induction of a potent and effective antitumor response. DCs have the specific role of recognizing cancer cells, taking up tumor antigens (Ags) and then migrating to lymph nodes for Ag (cross)-presentation to naïve T cells. Interferon-α-conditioned DCs (IFN-DCs) exhibit marked phagocytic activity and the special ability of inducing Ag-specific T-cell response. Here, we have developed a novel microfluidic platform recreating tightly interconnected cancer and immune systems with specific 3D environmental properties, for tracking human DC behaviour toward tumor cells. By combining our microfluidic platform with advanced microscopy and a revised cell tracking analysis algorithm, it was possible to evaluate the guided efficient motion of IFN-DCs toward drug-treated cancer cells and the succeeding phagocytosis events. Overall, this platform allowed the dissection of IFN-DC-cancer cell interactions within 3D tumor spaces, with the discovery of major underlying factors such as CXCR4 involvement and underscored its potential as an innovative tool to assess the efficacy of immunotherapeutic approaches.