bluuebunny/crossref_metadata_2025 huggingface dataset:
LEXICAL VARIATION AMONG STANDARD LANGUAGE SPEAKERS IN REPUBLIC OF SRPSKA
Authors: Yakushkina E.I. , Crnjak D.
Published: February 2024

This paper is a part of a larger study of regional variation of the lexicon within the Serbian standard language. About 100 questionnaires were collected for this research from educated speakers of the Serbian language from different cities. The questionnaire contains questions which uncover the use of doublets characteristic of the western and eastern parts of the Serbian linguistic territory, such as željezo and gvožđe, mahune and boranija, kino and bioskop. The paper proposes the analysis of around 60 questionnaires from the Republic of Srpska, namely from Banja Luka (47), Trebinje (7), as well as from Prijedor, Bjelina and East Sarajevo. First, the paper presents a list of investigated regional doublets (200 lexemes), and gives their typological division (phonetic or morphological variants, lexical doublets).

Further, a linguageographic analysis of the first questionnaire is proposed and previously analysed in the other paper, and conclusions about the regional characteristics of the lexicon contained in that questionnaire are presented. For example, it is noted that in Prijedor, unlike Trebinje, words as domaća zadaća, duda, hladetina, hlače, ispričnica, kuhar, kuhati, marelice, neodgojen, propuh, ručnik, tekućina, tržnica, tuka, umjetno gnojivo etc., are used.

The main content of the paper deals with the analysis of the second questionnaire. For each lexical pair presented in the questionnaire, the statistics of the use of each word in Banja-Luka and Trebinje are given, and based on this, the lexicon characteristic of one and the other city is distinguished (e.g. dan i noć, trougao in Trebinje and maćuhice, trokut in Banja Luka), as well as a group of doublet pairs whose members are used equally often in the west and in the east of the Republic of Srpska (oprosti – izvini). Words which practically do not vary are also described. Sometimes the same word is used in Banja Luka and Trebinje, and sometimes it is the same as in Serbia (putarina), or it may be different (narandža instead of pomorandža).

The main conclusion of the research is that the lexicon of the western and eastern type on the territory of the Republic of Srpska is distributed in the form of waves. This means that the use of lexical doublets in Trebinje is more similar to their use in Serbia, while for Banja Luka and Prijedor a higher concentration of western words than in Trebinje is typical.

Further research will be focused on the description of the use of these lexemes in other cities of the Republic of Srpska, as well as their variation on the territory of Serbia.
SIMEON POLOTSKY’S DRAMA NEBUCHADNEZZAR THE TSAR AND ITS WESTERN-EUROPEAN DRAMA SOURCES
Authors: Petković Ivana I.
Published: February 2024

Тhis paper aims to reconsider the influences of Western-European drama of the XVII century on the creation of Russian baroque and the first drama writer in Russia Simeon Polotsky. During the initial period, Russian theatre, especially during the XVI and XVII centuries, was under the strong influences of Western theatre culture. This paper reconsiders the influence of German, French, English and Polish theatre plays. Plots of his playwright were popular and well known in Western European literature from the XII century. In this paper, we tried to reconsider those influences on the example of his drama Nebuchadnezzar the Tsar. This drama plot was well-known in Western European theatre, and Simeon Polotsky knew some of them.
ISOLATED IN THE BIG CITY: (RE)FORMING THE IDENTITY OF THE PROTAGONIST-FLÂNEUR IN TEJU COLE’S OPEN CITY AND SRĐAN VALJAREVIĆ’S PEOPLE AT THE TABLE
Authors: Stojanović Aleksandra Z. , Čebašek Aleksandra V.
Published: February 2024

The goal of this paper is to establish a connection between the ways identity is formed in the novels Open City by Nigerian-American author Teju Cole and People at the Table by Serbian author Srđan Valjarević. The protagonists of the aforementioned novels are immigrants who have found themselves in the isolated and urban space of the metropolis and are now trying to establish their place within it. We shall explore Charles Baudelaire’s notion of the flȃneur in an urban environment that greatly differs from the narrators’ previous homes. A reconfiguration of identity is necessary and this is accomplished through walking – an unconscious search for identity and its roots. We may ask ourselves: Is the city a constitutive element of the subject, or is the subject a social product of the city? The streets of New York and Amsterdam present the protagonists with opportunities to think about not only their current positions but their pasts. Confused and dissatisfied, they move within the big city searching for ways to accept their fates. A common element of both novels is the continual reflection of the past and social positions. The city forms the protagonists’ identities to the point that it creates a sense of disorientation and helplessness, thus destroying them. Walking is the most significant aspect of both novels, as only in movement can the identity of these flȃneurs come to light.
TRIP13 Activates Glycolysis to Promote Cell Stemness and
Strengthen Doxorubicin Resistance of Colorectal Cancer Cells
Authors: Liu Guangyi , Wang Huan , Ran Rui , Wang Yicheng , Li Yang
Published: February 2024

Background:

Chemotherapy resistance is one of the main causes of clinical
chemotherapy failure. Current cancer research explores the drug resistance mechanism
and new therapeutic targets. This work aims to elucidate the mechanism of thyroid hormone
receptor interactor 13 (TRIP13) affecting doxorubicin (DOX) resistance in colorectal
cancer (CRC).

Methods:

Bioinformatics analyses were employed to clarify TRIP13 expression in CRC
tissues and predict the correlation of the TRIP13 enrichment pathway with glycolysis-related
genes and stemness index mRNAsi. Quantitative real-time polymerase chain reaction
and western blot were adopted to analyze the expression of TRIP13 and glycolysis-
related genes. Cell Counting Kit-8 was utilized to determine the cell viability and
IC50 value. Western blot was employed to measure the expression of stemness-related
factors. Cell function assays were performed to detect cells' sphere-forming ability and
glycolysis level. Animal models were constructed to determine the effects of TRIP13 expression
on CRC tumor growth.

Results:

TRIP13 was significantly overexpressed in CRC, concentrated in the glycolysis
signaling pathway, and positively correlated with stemness index mRNAsi. High expression
of TRIP13 facilitated DOX resistance in CRC. Further mechanistic studies revealed
that overexpression of TRIP13 could promote cell stemness through glycolysis, which
was also confirmed in animal experiments.

Conclusion:

TRIP13 was highly expressed in CRC, which enhanced the DOX resistance
of CRC cells by activating glycolysis to promote cell stemness. These findings offer
new insights into the pathogenesis of DOX resistance in CRC and suggest that
TRIP13 may be a new target for reversing DOX resistance in CRC.
Immunosuppressive Microenvironment in H3K27 Mutant Pediatric
Diffuse Midline Glioma: Single-Cell and Bioinformatics Insights on
CD8A, IL7R, and ICAM1
Authors: Huang Jianhuang , You Guiting , Chen Quan , Lin Yunpeng , Lin Yijing , Liang Yu , Lin Caihou , Chen Jianwu
Published: February 2024

Background:

Diffuse midline gliomas (DMG) pose a grave threat as a malignant tumor
primarily affecting children in the pons region. These tumors exhibit a distinct and heightened resistance to therapeutic interventions, coupled with exceptionally aggressive behavior.

Methods:

In this study, we accessed DMG data from the Gene Expression Omnibus (GEO)
database. Subsequently, we performed functional annotation and conducted pathway enrichment
analysis as well as gene set enrichment analysis (GSEA). Constructing a protein-protein interaction (PPI) network, we identified pivotal hub genes. To evaluate the impact of these hub genes on
immune infiltration, we employed the CIBERSORT algorithm. Furthermore, to bolster our findings, we conducted a single-cell analysis.

Results:

Our findings indicate the involvement of CD8A, IL7R, and ICAM1 in immune responses
targeting diverse immune cell types, such as T cells, neutrophils, NK cells, dendritic cells, γδ T
cells, and Macrophages M1. Additionally, the presence of immune checkpoints, including IDO1
and TIGIT, likely contributes to intratumoral immunosuppression, thereby fostering the development of an aggressive phenotype and resistance in pediatric DMG.

Conclusion:

In conclusion, the collective findings of our study suggest the potential role of
CD8A, IL7R, and ICAM1 as innovative biomarkers for diagnosing and prognosticating pediatric
DMG. Moreover, these molecules hold promise as therapeutic targets in the management of this
disease. The implications of our research underscore the importance of exploring these novel avenues for improved patient outcomes.
Uncovering the Mechanisms of Cinnamic Acid Treating Diabetic Nephropathy Based on Network Pharmacology, Molecular Docking, and
Experimental Validation
Authors: Dai Limiao , He Yang , Zheng Siqiang , Tang Jiyu , Fu Lanjun , Zhao Li
Published: February 2024

Background:

Cinnamic acid (Cinn) is a phenolic acid of Cinnamomum cassia (L.) J.
Presl. that can ameliorate diabetic nephropathy (DN). However, comprehensive therapeutic targets
and underlying mechanisms for Cinn against DN are limited.

Objective:

In this study, a network pharmacology approach and in vivo experiments were
adopted to predict the pharmacological effects and mechanisms of Cinn in DN therapy.

Methods::

The nephroprotective effect of Cinn on DN was investigated by a streptozotocininduced
diabetes mellitus (DM) mouse model. The protein-protein interaction network of Cinn
against DN was established by a network pharmacology approach. The core targets were then
identified and subjected to molecular docking with Cinn.

Results:

Cinn treatment effectively restored body weight, ameliorated hyperglycemia, and reduced
kidney dysfunction markers in DM mice, also demonstrating a reduction in tissue injury.
Network pharmacology analysis identified 298 DN-Cinn co-target genes involved in various
biological processes and pathways. Seventeen core targets were identified, eight of which
showed significant differential expression in the DN and healthy control groups. Molecular
docking analysis revealed a strong interaction between Cinn and PTEN. Cinn treatment downregulated
the PTEN protein expression in DM mice.

Conclusion:

This study revealed the multi-target and multi-pathway characteristics of Cinn
against DN. Cinn improved renal pathological damage of DN, which was related to the downregulation
of PTEN.

other:

not applicable.
Therapeutic Potential of MSC-conditioned Medium: A Multifactorial
Approach to Enhance Wound Healing
Authors: Anbiyaiee Amir , Azizidoost Shirin , Farzaneh Maryam
Published: February 2024

Wound healing is a highly intricate process that involves a coordinated interplay of
various cellular and molecular events. In recent years, mesenchymal stem cells (MSCs) have
garnered significant attention as a promising therapeutic modality due to their remarkable regenerative properties. In addition to their capacity for direct tissue repair and differentiation,
MSCs release a diverse repertoire of bioactive factors into the surrounding microenvironment,
collectively termed an MSC-conditioned Medium (MSC-CM). This review aims to elucidate the
therapeutic potential of MSC-CM as a multifactorial approach to enhance wound healing. MSCCM encompasses an extensive range of factors, including growth factors, cytokines, chemokines, extracellular matrix proteins, and non-coding RNAs, which collectively orchestrate and
stimulate multiple cellular processes crucial for effective wound healing. Notably, these factors
play pivotal roles in promoting angiogenesis, stimulating the proliferation and migration of various cell types involved in wound repair, modulating the immune response, and facilitating extracellular matrix remodeling. Moreover, compelling evidence from preclinical and clinical
studies demonstrates that MSC-CM administration accelerates wound closure, enhances reepithelialization, and improves the quality of granulation tissue. By harnessing the therapeutic
potential of MSC-CM, we can pave the way for significant advancements in wound care, ultimately leading to improved patient outcomes.
An Insight into the Traditional Uses, Phytochemicals, and Pharmacological
Properties of Polyalthia bullata King
Authors: Hamid Hazrulrizawati Abd , Giwa Hadiza Shehu
Published: February 2024

Polyalthia bullata King or Tongkat Ali Hitam, a term in the Malay language, encompasses a diverse group of plants belonging to different genera of the Annonaceae family. The
native range of this species is Myanmar to Peninsula Malaysia, Borneo. It is a shrub or tree and
grows primarily in the wet tropical biome. These plants have been utilized in Malaysia and
Southeast Asia as an herbal aphrodisiac. The extracts of this plant have been reported to exert
pharmacological activities, such as antioxidant, cytotoxicity, and aphrodisiac properties. The
therapeutic properties of P. bullata are attributed to the presence of alkaloids and flavonoids.
This study thoroughly analyzes the phytochemical and pharmacological research on P. bullata
and its traditional medicinal properties. The review aims to provide a critical update on the scientific knowledge of P. bullata and to identify novel possibilities for investigating its therapeutic
potential. There is limited scientific research on the phytochemical components and pharmaceutical application of P. bullata. To date, only a few compounds have been identified and isolated.
There is a need for future studies to focus on the extraction technology, phytochemical profiling,
and isolation of bioactive compounds from P. bullata to fill the research gap as well as to provide an important theoretical basis and valuable references for researchers and pave the way for
the discovery and development of new and existing drugs.
A Comparison Between the Photodynamic Action of “Hypocrellin A” and “Pheophorbide a” against Bacteria and SARS-CoV-2 Virus --- A Mini-Review
Authors: Law Siu Kan
Published: February 2024

:

Hypocrellin A and Pheophorbide a are well-known organic chemicals that may be contained in herbal products. They can act as photosensitizers and have a strong photodynamic effect on
bacteria. In any case, are these photosensitizers appropriate for photodynamic treatment against the
SARS-CoV-2 infection? The principles of photodynamic therapy are the same regardless of the target. It causes selective cytotoxicity at the site of infection through activation of photosensitizer under
light irradiation to generate cytotoxic reactive oxygen species (ROS), leading to the death of infected
cells. Is antimicrobial photodynamic therapy a good choice against the SARS-CoV-2 virus?

Methods:

Nine electronic databases were searched, including WanFang Data, PubMed, Science
Direct, Scopus, Web of Science, Springer Link, SciFinder, and China National Knowledge Infrastructure (CNKI), regardless of term, and language restrictions. All eligible studies were analyzed
and summarized in this review.

Results:

“Hypocrellin A” and “Pheophorbide a” were effective for bacterial and SARS-CoV-2 in
photodynamic therapy. 99.98 % of S. aureus was killed when incubated with the 10-3 M Hypocrellin
A and illuminated a 490 nm in 30 mW/cm2 for 120 min. The difference was Pheophorbide a could
also inhibit gram-negative bacteria, such as P. aeruginosa with a concentration of 1 µg/ml for 2 hr
irradiated of a 671 nm laser in 0.3 W of 1 J, and a nearly 100 % suppression rate. “Hypocrellin A”
and “Pheophorbide a” with antiviral activity, and virucidal effects for preventing and treating the
infection.

Conclusion:

Based on previous studies, “Hypocrellin A” and “Pheophorbide a” are photosensitizers
used for photodynamic therapy against bacteria or SARS-CoV-2, however, much more works need
to be done in the future including the development of a better way for systematic infectious disease,
and its correlated infections for the application of photodynamic therapy.
Atonía patrimonial por el COVID-19: en la gestión municipal del Qoricancha y San Agustín (SG-3) del Centro Histórico del Cusco entre los años 2020 – 2021
Authors: Canales Zuniga Freed , Zapata Rodríguez Mohenir
Published: February 2024

El presente estudio se desarrolla en el contexto de crisis sanitaria por el COVID-19 y su impacto en la gestión municipal entre el 15 de marzo de 2020 al 29 de febrero de 2021 en el barrio de Qoricancha y San Agustín (SG-3) del centro histórico del Cusco, puesto que el desarrollo de la pandemia se localiza en los barrios urbanos donde habitan y trabajan personas, y fueron los municipios los que aplicaron actividades públicas para contrarrestar las externalidades negativas producidas por la pandemia. El artículo presenta cómo la Municipalidad Provincial del Cusco reacciona desde la perspectiva de los sujetos patrimoniales ante la presente crisis sanitaria en este sector del Cusco patrimonial a partir de sus instancias municipales que se dedican a la gestión y administración, planificación, generación de normas legales, captación financiera y activación de la cooperación interinstitucional e internacional, pretendemos articular la realidad situacional de la Municipalidad Provincial del Cusco frente a la responsabilidad de preservar el patrimonio cultural y la ciudadanía de esta sección de la ciudad histórica, revelando su real capacidad de acción frente a los permanentes problemas que afronta cotidianamente.
Deconstruyendo una utopía. Intenciones y repercusiones del Proyecto de Regeneración Urbana Integral PREVI - PP2 en la zona monumental de Barranco, Lima-Perú, 1968-2021
Authors: Arrieta Palomino Alvaro , Calizaya Valencia Leslie , Rouillon Acosta Manuel
Published: February 2024

El Proyecto Piloto de Renovación y Rehabilitación Urbana (PP2) fue desarrollado desde 1969 hasta 1976 y formó parte del Proyecto Experimental de Vivienda (Previ), el cual fue apoyado por la Organización de las Naciones Unidas. El PP2 buscó dar solución a los espacios tugurizados, tomando como área experimental cuatro manzanas de la Zona Monumental de Barranco (Lima, Perú). Ello sería la base de una Política Nacional de Rehabilitación de Vivienda, a través de una visión integral, multidisciplinaria e innovadora para su época. Pese a no ser ejecutado en su totalidad, sus características lo han colocado como la génesis de los procesos de regeneración urbana del Perú, en virtud del modelo de gestión en sus dimensiones social, económica, legal y de planificación.
Historia e importancia arquitectonica de la Casa de Jarava
Authors: Barrera Camarena Henry
Published: February 2024

Uno de los monumentos edificados que más sobresale en el centro histórico de Lima es la Casa de Jarava, conocida también como Casa de Pilatos (hoy sede del Tribunal Constitucional). Pese a los siglos transcurridos desde que fue construidA, todavía se aprecia buena parte de su originalidad arquitectónica y elementos artísticos. Entre ellos, los dos escudos nobiliarios hechos de piedra y provenientes del siglo XVII, ubicados en la parte superior de la fachada.Por otro lado, a través del empleo de fuentes primarias se rescata el devenir de la finca desde mediados de la decimoséptima centuria hasta finales del siglo XX, incluyendo los diferentes propietarios que tuvo y un análisis de la versión dada por Ricardo Palma en torno al apelativo “Pilatos” que le dio a la casa. De esta manera, se buscar enfatizar en el valor histórico que posee y la importancia de su conservación.
Por otro lado, a través del empleo de fuente primaria se rescata el devenir de la finca desde mediados de la decimoséptima centuria hasta finales del siglo XX, incluyendo los diferentes propietarios que tuvo y un análisis de la versión dada por Ricardo Palma en torno al apelativo “Pilatos” que le dio a la casa. De esta manera, se buscar enfatizar en el valor histórico que posee y la importancia de su conservación.
Fuentes de Agua. Patrimonio Hídrico del Centro Histórico del Cusco
Authors: Salas Velásquez Victor
Published: February 2024

El objetivo de la presente investigación es determinar los tipos de fuentes de agua y su uso en los espacios públicos en el centro histórico del Cusco mediante una investigación cualitativa del tipo historiográfica. Los resultados muestran que en la sociedad inca fueron usadas ceremonialmente en la configuración del Apu Llaqta (asentamiento sagrado), cambiando de paradigma en el periodo virreinal al ser el suministro principal de agua en los espacios públicos y privados bajo una concepción renacentista y barroca, llegando a su apogeo en el periodo republicano hasta su desuso por el impacto negativo del paradigma modernizador, continuando así durante el siglo XX. Producto del estudio de campo, se constató que las fuentes de agua son consideradas como elementos arquitectónicos ornamentales del equipamiento urbano; en sus configuraciones, tanto la materia como la manifestación del recurso hídrico son una unidad, pero las de estilo virreinal y moderno no tienen agua, solo las de estilo inca y contemporáneo preservan el agua que, después de tener un uso ornamental, termina en el sistema de alcantarillado o desagüe porque la gestión local vigente no reconoce el patrimonio hídrico.
Los Cementerios Tradicionales como Museos a Cielo Abierto. Indagaciones sobre el Potencial del Cementerio General de Santiago de Chile
Authors: Valencia Palacios Marco
Published: February 2024

El artículo busca reconocer el potencial de los cementerios tradicionales como museos a cielo abierto. Para ello, se definen los valores culturales presentes en las necrópolis, especificando la naturaleza de los bienes que definen el patrimonio funerario. Desde una mirada crítica se señalan las dificultades por las que atraviesan los camposantos decimonónicos en el presente, indicando los principales desafíos en materia de preservación y puesta en valor de sus bienes culturales. Para ello, se desarrolla un estudio de referentes mediante fuentes documentales y bibliográficas. Finalmente, se indaga en la potencialidad museística de los cementerios chilenos, tomando como caso específico el Cementerio General de Santiago de Chile.
Roberto Machicao Relis
Authors: Gondo Minami Rita
Published: February 2024

“[…] El propósito fundamental del docente en Arquitectura es que el alumno entienda. Por lo menos yo trato que las clases sean siempre coloquiales. Porque el problema no es demostrar que lo saben, el problema es que ustedes entiendan. Eso es lo único. Lo importante es despertar en ustedes ese conocimiento que está dormido, está latente, y que está esperando una buena oportunidad para salir […]”. Esta y muchas otras ideas escuchamos quienes estuvimos en clases como alumnos y, sobre todo, quienes compartimos aula y cátedra junto al ingeniero Roberto Machicao Relis, pionero en la enseñanza de las estructuras, con una visión diferente de la vida y de la enseñanza de las estructuras en la arquitectura.
Detrás del diseño. Las Escuelas Latinoamericanas de Arquitectura y el Movimiento Moderno
Authors: Vela Cossío Fernando
Published: February 2024

Se ha cumplido este año el centenario de la publicación del libro Enseñanza de la Arquitectura. Cultura moderna técnico artística (Madrid, 1923). Su autor, Teodoro de Anasagasti Algán (1880-1938), se tituló en la Escuela Superior de Arquitectura de Madrid en 1906. Después de un breve periodo de ejercicio profesional en Bermeo (Vizcaya) disfrutó de un pensionado en Roma durante 1909 y viajó entre 1910 y 1914 por Centroeuropa, tomando contacto con los movimientos de vanguardia. A su regreso a España, incorporado como catedrático de proyectos en la escuela, promovió la reforma de los viejos procedimientos y métodos formativos que, heredados del siglo XIX, seguían vigentes en las universidades españolas. Publicado en un contexto que anticipaba la introducción en España de la arquitectura moderna, aquel libro invitaba a la reflexión sobre los principales problemas de la enseñanza de la disciplina y sobre sus soluciones: simplificación de contenidos de los planes de estudio, búsqueda de una enseñanza integral, más práctica y la imprescindible revisión de los anacrónicos métodos pedagógicos sobre los que descansaba la formación de los arquitectos españoles. En uno de los textos reunidos en la obra Así se enseña en Múnich y Viena (1918) recordaba Anasagasti cómo «para cuantos procedemos de aquel destartalado caserón de la calle de los Estudios (refiriéndose al antiguo Colegio Imperial, fundado en el siglo XVII), el más detestable de los edificios madrileños destinados a la enseñanza, y que, por incuria de los Gobiernos, se utiliza para Escuela de Arquitectura, es indudable que la visita de otros similares establecimientos tiene que inspirarnos tanta curiosidad como el estudio» y dejaba testimonio de la impresión que le habían causado el politécnico de Múnich y la Escuela de Arquitectura de Viena.
The Relationship of Servant Leadership on Knowledge Sharing Behavior With Organizational Culture and Organizational Citizenship Behavior As Mediator
Authors: Srimulyani Veronika Agustini , Rustiyaningsih Sri , Hermanto Yustinus Budi
Published: February 2024

This study aims to analyze the relationship between servant leadership (SL) on organizational culture (OC), organizational citizenship behavior (OCB), and knowledge-sharing behavior (KSB) to test the indirect relationship of servant leadership (SL) on organizational culture (OC), organizational citizenship behavior (OCB), and knowledge sharing behavior (KSB), as well as to test the indirect relationship of SL to OCB and KSB through OC. The research design used a quantitative method; the research samples were 60 village officials from one of the sub-districts in Magetan Regency, East Java, Indonesia. Data collection was carried out by way of a survey using a questionnaire. The research results showed that SL has a significant positive relationship with OC and OCB, but SL does not have a direct relationship with KSB; OC has a significant positive relationship with OCB and KSB; OCB is not directly related to KSB; OC plays a partial mediating role in the relationship between SL and OCB; OC as a full mediation of the relationship between SL and KSB. Realizing KSB can be improved through the internalization of organizational culture, which can increase OCB and encourage organizational members to share knowledge.
Arabic Web-Based Information on Oral Lichen Planus: Content Analysis
Authors: AlMeshrafi Azzam , AlHamad Arwa F , AlKuraidees Hamoud , AlNasser Lubna A
Published: February 2024

Background

The use of web-based health information (WBHI) is on the rise, serving as a valuable tool for educating the public about health concerns and enhancing treatment adherence. Consequently, evaluating the availability and quality of context-specific WBHI is crucial to tackle disparities in health literacy and advance population health outcomes.

Objective

This study aims to explore and assess the quality of the WBHI available and accessible to the public on oral lichen planus (OLP) in Arabic.

Methods

The Arabic translation of the term OLP and its derivatives were searched in three general search platforms, and each platform’s first few hundred results were reviewed for inclusion. We excluded content related to cutaneous LP, content not readily accessible to the public (eg, requiring subscription fees or directed to health care providers), and content not created by health care providers or organizations (ie, community forums, blogs, and social media). We assessed the quality of the Arabic WBHI with three standardized and validated tools: DISCERN, Journal of the American Medical Association (JAMA) benchmarks, and Health On the Net (HON).

Results

Of the 911 resources of WBHI reviewed for eligibility, 49 were included in this study. Most WBHI resources were provided by commercial affiliations (n=28, 57.1%), with the remainder from academic or not-for-profit affiliations. WBHI were often presented with visual aids (ie, images; n=33, 67.4%). DISCERN scores were highest for WBHI resources that explicitly stated their aim, while the lowest scores were for providing the effect of OLP (or OLP treatment) on the quality of life. One-quarter of the resources (n=11, 22.4%) met all 4 JAMA benchmarks, indicating the high quality of the WBHI, while the remainder of the WBHI failed to meet one or more of the JAMA benchmarks. HON scores showed that one-third of WBHI sources had scores above 75%, indicating higher reliability and credibility of the WBHI source, while one-fifth of the sources scored below 50%. Only 1 in 7 WBHI resources scored simultaneously high on all three quality instruments. Generally, WBHI from academic affiliations had higher quality scores than content provided by commercial affiliations.

Conclusions

There are considerable variations in the quality of WBHI on OLP in Arabic. Most WBHI resources were deemed to be of moderate quality at best. Providers of WBHI could benefit from increasing collaboration between commercial and academic institutions in creating WBHI and integrating guidance from international quality assessment tools to improve the quality and, hopefully, the utility of these valuable WBHI resources.
Nudges and Prompts Increase Engagement in Self-Guided Digital Health Treatment for Depression and Anxiety: Results From a 3-Arm Randomized Controlled Trial
Authors: van Mierlo Trevor , Rondina Renante , Fournier Rachel
Published: February 2024

Background

Accessible and effective approaches to mental health treatment are important because of common barriers such as cost, stigma, and provider shortage. The effectiveness of self-guided treatment is well established, and its use has intensified because of the COVID-19 pandemic. Engagement remains important as dose-response relationships have been observed. Platforms such as Facebook (Meta Platform, Inc), LinkedIn (Microsoft Corp), and X Corp (formerly known as Twitter, Inc) use principles of behavioral economics to increase engagement. We hypothesized that similar concepts would increase engagement in self-guided digital health.

Objective

This 3-arm randomized controlled trial aimed to test whether members of 2 digital self-health courses for anxiety and depression would engage with behavioral nudges and prompts. Our primary hypothesis was that members would click on 2 features: tips and a to-do checklist. Our secondary hypothesis was that members would prefer to engage with directive tips in arm 2 versus social proof and present bias tips in arm 3. Our tertiary hypothesis was that rotating tips and a to-do checklist would increase completion rates. The results of this study will form a baseline for future artificial intelligence–directed research.

Methods

Overall, 13,224 new members registered between November 2021 and May 2022 for Evolution Health’s self-guided treatment courses for anxiety and depression. The control arm featured a member home page without nudges or prompts. Arm 2 featured a home page with a tip-of-the-day section. Arm 3 featured a home page with a tip-of-the-day section and a to-do checklist. The research protocol for this study was published in JMIR Research Protocols on August 15, 2022.

Results

Arm 3 had significantly younger members (F2,4564=40.97; P<.001) and significantly more female members (χ24=92.2; P<.001) than the other 2 arms. Control arm members (1788/13,224, 13.52%) completed an average of 1.5 course components. Arm 2 members (865/13,224, 6.54%) clicked on 5% of tips and completed an average of 1.8 course components. Arm 3 members (1914/13,224, 14.47%) clicked on 5% of tips, completed 2.7 of 8 to-do checklist items, and completed an average of 2.11 course components. Completion rates in arm 2 were greater than those in arm 1 (z score=3.37; P<.001), and completion rates in arm 3 were greater than those in arm 1 (z score=12.23; P<.001). Engagement in all 8 components in arm 3 was higher than that in arm 2 (z score=1.31; P<.001).

Conclusions

Members engaged with behavioral nudges and prompts. The results of this study may be important because efficacy is related to increased engagement. Due to its novel approach, the outcomes of this study should be interpreted with caution and used as a guideline for future research in this nascent field.

International Registered Report Identifier (IRRID)

RR2-10.2196/37231
Dialysate Sodium Lowering in Maintenance Hemodialysis
Authors: Miskulin Dana C. , Tighiouart Hocine , Hsu Caroline M. , Weiner Daniel E.
Published: February 2024

Key Points

Treatment to dialysate sodium 135 versus 138 mEq/L led to no difference in the rate of change in intradialytic hypotension, but symptoms were greater in the low arm.

Use of a dialysate sodium concentration of 135 versus 138 mEq/L led to a small reduction in interdialytic weight gain, but had no effect on predialysis BP.

Raising dialysate sodium concentration from 135 to 140 mEq/L reduced intradialytic hypotension and was associated with a marked increase in BP.

Background

Lowering dialysate sodium concentration may improve volume and BP control in patients on maintenance hemodialysis.

Methods

We randomized 42 participants 2:1 to dialysate sodium 135 versus 138 mEq/L for 6 months. This was followed by a 12-week extension phase in which sodium was increased to 140 mEq/L in low-arm participants. The primary outcome was intradialytic hypotension (IDH). Secondary outcomes included dialysis disequilibrium symptoms, emergency room visits/hospitalizations, interdialytic weight gain, and BP. Longitudinal changes across arms were analyzed using linear mixed regression.

Results

Treatment to dialysate sodium 135 versus 138 mEq/L was not associated with a difference in a change in the rate of IDH (mean change [95% confidence interval], 2.8 [0.8 to 9.5] versus 2.7 [1.1 to 6.2] events per 100 treatments per month); ratio of slopes 0.96 (0.26 to 3.61) or emergency room visits/hospitalizations (7.3 [2.3 to 12.4] versus 6.7 [2.9 to 10.6] events per 100 patient-months); difference 0.6 (−6.9 to 5.8). Symptom score was unchanged in the 135 mEq/L arm (0.7 [−1.4 to 2.7]) and decreased in the 138 mEq/L arm ([5.0 to 8.5 to 2.0]; difference 6.0 [2.1 to 9.8]). Interdialytic weight gain declined in the 135 mEq/L arm and was unchanged in the 138 mEq/L arm (−0.3 [−0.5 to 0.0] versus 0.3 [0.0 to 0.6] kg over 6 months; difference [−0.6 (−0.1 to −1.0)] kg). In the extension phase, raising dialysate sodium concentration from 135 to 140 mEq/L was associated with an increase in interdialytic weight gain (0.2 [0.1 to 0.3] kg) and predialysis BP (7.0 [4.8 to 9.2]/3.9 [2.6 to 5.1] mm Hg) and a reduction in IDH (odds ratio, 0.66 [0.45 to 0.97]).

Conclusions

Use of a dialysate sodium concentration of 135 as compared with 138 mEq/L was associated with a small reduction in interdialytic weight gain without affecting IDH or predialysis BP, but with an increase in symptoms. Raising dialysate sodium concentration from 135 to 140 mEq/L was associated with a reduction in IDH, small increase in interdialytic weight gain, and marked increase in predialysis BP.

Clinical Trial registration number

NCT03144817.
The World Adrift Between Orders: The History of the American Far Right and its Impact on US-Mexico Relations. Past and Present
Authors: Anduiza Pimentel Marcel Sebastián
Published: February 2024

Taking a long-term historical perspective, this article delves into the history of sifting political orders and far-right rebellions in the United States, examining their profound impact on US-Mexico relations. Far-right rebellions are complex political phenomena, deeply rooted in three distinct American political traditions and movements: populism, illiberalism, and isolationism. All three have periodically reshaped the landscape of American politics, notably during transitions such as the current crisis facing the Washington Consensus and the liberal international order. In the past, US-Mexico relations appeared insulated from those far-right rebellions that periodically emerge from political transitions. However, this is no longer the case. The rise of Trumpism today has established the foundational framework for a new era of strained US-Mexico relations amid escalating geopolitical instability on a global scale.
Cybercrime and the Law: Addressing the Challenges of Digital Forensics in Criminal Investigations
Authors: Allah Rakha Naeem
Published: February 2024

A lack of standards and regulations for handling digital evidence is impeding its admissibility in court proceedings. This article addresses the challenges of digital forensics in criminal investigations due to the rise of cybercrime. The literature existing studies on digital forensics, legal frameworks, and cybercrime is reviewed in order to find possible solutions. The results demonstrate the importance of collaboration between the legal and technological sectors in developing standardized norms and processes for digital evidence collection and processing. The findings also highlight the importance of digital forensics in criminal investigations and the need for a robust legal framework to combat cybercrime effectively. This note emphasizes the vital significance of digital forensics in criminal investigations and the need to develop standardized rules and procedures for the management of digital evidence. The recommendations presented in this article may assist policymakers and law enforcement authorities in designing legal framework capable of effectively confronting cybercrime.
Intrusion Detection System using Blockchain
Authors: Kaur Avneet , Pawar Shruti , Jore Neha , Chavan Varsha , Mule Nikita
Published: February 2024

Abstract: This paper investigates the integration of an Intrusion Detection System (IDS) within the context of blockchain technology. The objective is to enhance the security posture of blockchain networks by detecting and mitigating potential intrusions. Through a meticulous examination of the current threat landscape and the unique challenges posed by blockchain systems, this research proposes a robust IDS framework tailored to the specific requirements of decentralized and distributed ledger environments. The study employs [specific methodology/approach] to assess the effectiveness of the proposed IDS, presenting conclusive findings that contribute to the ongoing discourse on securing blockchain ecosystems. The implications of this research extend to bolstering the resilience of blockchain networks against emerging threat.
Self-Identifying Alcohol Scene Detection from Video and Showing the Message Alcohol Consumption is Injurious to Health
Authors: Dutta Rohan
Published: February 2024

Abstract: The proposed project aims to detect alcohol consumption from real time video footage using machine learning and show the message "Alcohol consumption is injurious to health".
The effectiveness of problem-based learning in improving creative thinking skills, collaborative skills and environmental literacy of Muhammadiyah secondary school students
Authors: Nurwidodo N. , Wahyuni Sri , Hindun Iin , Fauziah Nur
Published: February 2024

This research aimed to analyze the effectiveness of the problem-based learning (PBL) model in improving creative thinking skills, collaborative skills and environmental literacy of Muhammadiyah secondary school (Senior High School and Vocational School) students. The type of research is quasi-experimental. The research design uses Pretest-Posttest Non-equivalent Control Group Design. The experimental research was preceded by a survey regarding the independent and dependent variables, followed by the development of learning tools consisting of a syllabus, student worksheets, creative thinking skills instrument, collaborative skills instrument and environmental literacy instrument. The research sample consisted of 150 grade 10 students taken by total sampling. Data was obtained through observation, questionnaires and tests. The research was conducted from September to December 2023. Analysis of covariance (ANCOVA) was used to verify the data against the proposed hypothesis. The research results show that PBL is effective in improving creative thinking skills, collaborative skills and environmental literacy of Muhammadiyah secondary school students in Batu City. PBL can be implemented widely in an effort to develop creative thinking skills, collaborative skills and environmental literacy.
Impacto psicosocial de la pandemia y estallido social sobre las poblaciones afrodescendientes del Huila
Authors: Rebolledo Cortés Henry Steven , Gutiérrez Osorio Leonardo
Published: February 2024

El presente documento refleja un trabajo diagnóstico psicosocial comunitario que se desarrolló con comunidades afrodescendientes presentes en Neiva y alrededores como el municipio de Rivera y Campoalegre. La estrategia metodológica consistió en un diagnóstico a partir de dos fases: primero la consulta y socialización con líderes de tres organizaciones afro en cada municipio. En la segunda fase se llevaron a cabo entrevistas semiestructuradas con familias vinculadas a las organizaciones. Así como dos grupos de discusión con los líderes de la Asociación Pacífico por la Paz. El mues-treo de este diagnóstico ha sido no probabilístico por conveniencia, considerando que los participantes se vinculan al mismo en bola de nieve. Los participantes son personas en su mayoría que han sido víctimas del desplazamiento forzado a causa de la violencia en Colombia específicamente en los departamentos del Cauca, Valle del Cauca, Nariño y Buenaventura; algunos de ellos ya son nacidos en el departamento del Huila, debido a que sus familias llevan bastante tiempo establecidos en este lugar del país. Se autorreconocen como afrocolombianos, vinculados a organizaciones sociales afro en el Huila. Los resultados arrojan condiciones socioeconómicas, educativas, psicosociales y de bienestar que permiten tener un análisis no generalizable, pero que posibilita una línea de base para demás investigaciones y programas de impacto social con la comunidad. Dentro de las necesidades establecidas se logra identificar una alta necesidad de programas sociales, culturales, de formación, un rezago en las políticas públicas locales y altas necesidades económicas, además de procesos de resiliencia desde los diálogos establecidos.
Modelo teórico y aplicabilidad de la BEI como experiencia en la transformación laboral
Authors: Rivera Quintero Katherine , Salcedo Rojas Erika Julieth , Duque Jiménez Lina Marcela , Montenegro Ingrid Alejandra , Castro Eilyn , Rengifo Cuervo Jeisson Tobías
Published: February 2024

Evaluar competencias dentro de las organizaciones se ha convertido en un aspecto esencial en diferentes ámbitos del desarrollo organizacional tales como: la selección de personal, análisis del desempeño y satisfacción laboral en cualquiera de los cargos que requieren las empresas, ya que a través de la implementación de herramientas como la entrevista de incidentes críticos BEI se evalúa la capacidad que tiene el entrevistado para afrontar situaciones que demanden una respuesta específica de sus competencias, además de permitir contar con un registro del comportamiento de los entrevistados (De Oliveira y Aylmer, 2019). En el presente artículo se desarrolla una revisión bibliográfica de carácter descriptiva, posteriormente se identifican y detallan las diferentes aplicaciones de la entrevista BEI en el entorno organizacional, reconociendo su funcionalidad en dicho contexto. Después de su revisión y conceptualización, se concluye que, es la principal y más completa técnica de evaluación por competencias a nivel organizacional, pero que, dada su complejidad y profundidad se debe contar con una variedad de recursos para su elaboración adecuada.
Board diversity and enterprise risk management: Study in emerging and developed countries
Authors: Ghofar Abdul
Published: February 2024

Globalization and the uncertainty of the business environment pose challenges to companies. The unpredictable COVID-19 pandemic has caused a significant global recession. For this reason, every company is required to improve governance and risk management practices to reduce the impact of this uncertainty. This study investigated the effect of board diversity on enterprise risk management (ERM) in companies in the USA, China, and Indonesia using the enterprise risk management index (ERMI) to measure ERM. ERMI is a means to assess an organization’s ERM implementation effectiveness index based on its ability to achieve its goals based on four dimensions (strategy, operations, reporting, and compliance). Different findings were uncovered in the 3 countries studied using the panel regression analysis technique on a sample of 629 companies during an observation period of 2011–2021. In the USA, a country known for prominent individualism, overall gender diversity does not have a significant relationship with risk-management-related decision-making. In China, gender and cultural diversities negatively impact ERM. On the other hand, in the Indonesian context, skill diversity has no significant relationship with risk management, while tenure diversity has a negative effect on ERM. The results of this study provided recommendations for regulators and company management in developing good corporate governance.
El tranvía en el proceso de expansión urbana y modernización de Pereira: 1922-1953
Authors: Montoya Ferrer Jaime , Osorio Velásquez Jorge Enrique
Published: February 2024

El artículo se aproxima a la realidad urbana de Pereira, Colombia, durante la génesis del tranvía. Narra y analiza el desarrollo de este sistema de transporte, sus efectos y las posibles implicaciones que habrían surgido al contar con un modelo urbanístico que definiera su rol en función de un ideal de ciudad. Esboza además una perspectiva en la que el tranvía aparece como el reflejo de una sociedad que buscaba poner su urbe al nivel de las grandes capitales colombianas, en un momento de pujanza sustentado por la caficultura, el comercio y en la industria manufacturera. Sin embargo, Pereira no llegó a tener el tamaño ni la población que le hubiera permitido ser sostenible financieramente.
Presentación del número
Authors: Martínez Botero Sebastián
Published: February 2024

Presentación del volumen 7, número 2 de Ciencia Nueva, revista de historia y política, correspondiente al segundo semestre del año 2023 (julio-diciembre).