bluuebunny/crossref_metadata_2025 huggingface dataset:
Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency
Authors: Malyukov Maria , Gelfgat Evgeny , Ruiz‐Babot Gerard , Schmid Janine , Lehmann Susann , Spinas Giatgen , Beuschlein Felix , Hantel Constanze , Reisch Nicole , Nawroth Peter P. , Bornstein Stefan R. , Steenblock Charlotte , Ludwig Barbara
Published: August 2023

Primary adrenal insufficiency is a life‐threatening disorder, which requires lifelong hormone replacement therapy. Transplantation of xenogeneic adrenal cells is a potential alternative approach for the treatment of adrenal insufficiency. For a successful outcome of this replacement therapy, transplanted cells should provide adequate hormone secretion and respond to adrenal physiological stimuli. Here, we describe the generation and characterization of primary porcine adrenal spheroids capable of replacing the function of adrenal glands in vivo. Cells within the spheroids morphologically resembled adult adrenocortical cells and synthesized and secreted adrenal steroid hormones in a regulated manner. Moreover, the embedding of the spheroids in alginate led to the formation of cellular elongations of steroidogenic cells migrating centripetally towards the inner part of the slab, similar to zona Fasciculata cells in the intact organ. Finally, transplantation of adrenal spheroids in adrenalectomized SCID mice reversed the adrenal insufficiency phenotype, which significantly improved animals’ survival. Overall, such adrenal models could be employed for disease modeling and drug testing, and represent the first step toward potential clinical trials in the future.
Augmented Performance and Wake Management in Finned Tube Arrays Through Hierarchical Deployment of Toe-Out Winglets
Authors: Arora Amit , Subbarao P. M. V.
Published: August 2023

Downsizing the heat exchanger without compromising its heat exchange capacity is highly desirable for containing the box volume of a thermal management system. This investigation seeks to substantially boost the thermal compactness of a widely used gas-to-liquid heat exchanger, called finned tube arrays. For that purpose, winglet-type vortex generators are adopted. The novelty of the present study lies in the fact that it uses regression analysis to develop thermo-hydraulic functional correlations corresponding to three diverse design parameters of winglet-type vortex generators: the attack angle, the location and the geometric aspect ratio. In addition, enhancement in the wake-affected heat transfer is specifically examined, followed by a proof-of-concept study by making the best design(s) of vortex generators perform under widely varying operating conditions. Based on a thermo-hydraulic assessment of the generators' attack angle, 45-degrees is the limiting value of optimal attack angle. Although multiple winglet locations are found to deliver the desired thermal augmentation, a few locations incur disproportionate flow loss whereas majority locations facilitate linearized thermal augmentation. It is encouraging to find that the relative Colburn j-factor of the modified heat exchanger increases with the Reynolds number, despite the absolute values bearing an inverse correlation. While the highest augmentation in the average Colburn j-factor equals 44.1%, it is 150.1% over the wake-affected fin surface.
Aerodynamic Noise Characteristics of Axial Flow Fan in Narrow Space and Noise Reduction Based on Flow Control
Authors: Sun Zonghan , Chai Pengfei , Tian Jie , Du Zhaohui , Ouyang Hua
Published: August 2023

The aeroacoustic characteristics of a power module in the electric vehicle charging pile is studied by experimental and numerical methods. In the free field, a single cooling fan mainly emits tonal noise, while the far-field noise of fans in parallel satisfied the superposition of incoherent sound sources. However, when two fans in parallel delivered air into the power module, the noise increased significantly, especially broadband noise. Referring to the power module, a narrow space model with cooling fan supplying air inward is constructed. The computational fluid dynamics results show that the mass flowrate of the fan is reduced due to the obstacles downstream, which weakens the heat dissipation performance. Part of the fluid forms reflux, interacts with the fan and strengthens the corner vortex. By setting guide holes on the casing near the flow blockage to arrange flow, the flow resistance is reduced and the total mass flowrate of the fan is increased by 2.5%. The reflux and corner vortex are dispersed, and the vortices develop downstream, thus reducing the interaction with the fan. The predicted tonal sound pressure level (SPL) decreases by 3.2 dBA based on acoustic analogy method. The broadband noise caused by shedding vortex is also predicted and discussed by a semi-empirical model. In the noise reduction experiment of the real power module, combining inlet bellmouth on the fan and guide holes on the casing, the total SPL was significantly reduced by 2.9 dBA. Especially, based on bellmouth, guide holes brought an additional 1.9 dBA tonal noise reduction and 1.0 dBA total SPL reduction. The study indicates that appropriate flow control is important to improve the heat dissipation and reduce noise of the power module. These results are helpful to develop higher power charging system.
Redescription of the larval stage of Dermacentor parumapertus Neumann (Acari: Ixodidae), with notes on hosts
Authors: GODDARD JEROME , BAKER GERALD T. , PADDOCK CHRISTOPHER D. , SMITH TRAVIS C. , ROBBINS RICHARD G.
Published: August 2023

The larva of the ixodid tick Dermacentor parumapertus Neumann, chiefly a parasite of hares and rabbits, is redescribed using scanning electron micrographs of seven specimens derived from two engorged females collected from two black-tailed jackrabbits, Lepus californicus, at the Black Gap Wildlife Management Area, Brewster County, southwestern Texas. The use of chaetotaxy for separating the genera of Ixodidae is discussed, and a morphological key is provided for separating the larvae of D. parumapertus from those of five other Dermacentor species with partly sympatric geographic ranges.
Host associations of the Asian monitor lizard tick Amblyomma varanense (Supino, 1897) (Ixodida: Ixodidae), with a new host record from the Philippines
Authors: AMARGA ACE KEVIN S. , ROBBINS RICHARD G. , LIN SI-MIN
Published: August 2023

Amblyomma varanense (Supino) (Ixodida: Ixodidae) is a reptile-associated bont tick native to the Oriental and Australasian zoogeographic regions. This species is primarily ectoparasitic on monitor lizards (Varanidae) and snakes but has been reported to occasionally occur on turtles and mammals. Prior to the research described here, only one collection of A. varanense had been reported from the Philippines. Herein, we present a second Philippines collection of A. varanense as well as updated host records across this tick’s geographic range and an overview of associated microbes with zoonotic potential.
Supplemental Material: Seeing is believing: Climate change graph design and user judgments of credibility, usability, and risk
Authors: Courtney Steph L. , McNeal Karen S.
Published: August 2023

Additional methodology and analysis details including results not central to the primary findings of the manuscript. 
Supplemental Material: Provenance of Devonian–Carboniferous sedimentary rocks of the Tarija Basin, southern Bolivia: Implications for the geodynamic evolution of the southwestern margin of Gondwana
Authors: Zavaleta Arnold García , Hauser Natalia , et al.
Published: August 2023

Contains detailed information about rock sampling and analytical methods used for the development of this work. Also includes tables and supplementary images.
Supplemental Material: The formation of a giant post-collision porphyry copper system: A case study of the Jiama deposit, Tibet
Authors: Sun Miao , Lin Bin , et al.
Published: August 2023

Supplemental Text S1: Analytical Methods. Figures S1–S4. Table S1: LA-ICP-MS zircon U-Pb isotopic data for different magmatic rocks of the Jiama deposit. Table S2: LA-ICP-MS zircon trace element data for different magmatic rocks of the Jiama deposit. Table S3: Whole-rock major and trace element data for different magmatic rocks of the Jiama deposit. Table S4: Sr-Nd isotopic compositions for different magmatic rocks of the Jiama deposit. Table S5: Representative electron-microprobe results of plagioclase phenocryst in the Jiama monzogranite porphyry. Table S6: REE modelling on batch melting for Jiama primary adakite-like magmas. Table S7: Whole-rock geochemistry model setup and partition coefficients for the silicic magma evolution.
Supplemental Material: Water contents and hydrogen isotope compositions of amphibole in aillikites from the Tarim large igneous province, NW China: Insight into Earth’s deep water cycle
Authors: Wang Chang Hong  , Zhang Zhaochong , et al.
Published: August 2023

Supplemental Tables S1–S7.
Supplemental Material: Investigating weathering signatures in terrestrial muds: Can climatic signatures be separated from provenance?
Authors: Demirel-Floyd Cansu , et al.
Published: August 2023

Supplemental materials contain metadata (descriptions, geographic locations), and all analysis results discussed in the text.
Attachment and trauma-informed programme to support forcibly displaced parents of youth in Sweden: feasibility and preliminary outcomes of theeConnect Onlineprogramme
Authors: Kristen Anna , Salari Raziye , Moretti Marlene , Osman Fatumo
Published: August 2023

Objectives

To assess the feasibility, acceptability and the impact of an online parenting programme for forcibly displaced parents of adolescents.

Design

The study was a single-arm feasibility study using pre-intervention post-intervention and follow-up assessments.

Setting

Participants were recruited from municipality-based activities for refugee parents in a small city in the south of Sweden.

Participants

Participants were forcibly displaced parents (n=23; 47.8% maternal figures) of youth (n=23; 8–17 years old; 26.1% female) from Syria, Afghanistan and Somalia participating in an online parenting programme (eConnect).

Intervention

eConnectis an attachment-based and trauma-informed parenting intervention and was delivered over the course of 10 weekly sessions.

Primary and secondary outcome measures

Feasibility was assessed by programme enrolment, attendance, completion and acceptability of the online platform and cultural fit of the programme. Primary outcome measures were programme impact on youth mental health problems. Secondary outcome measures were programme impact on family functioning and parent–child attachment insecurity.

Results

TheeConnectprogramme was highly feasible in terms of overall enrolment (100%), attendance (89.6%) and retention rates (100%). The online platform was acceptable, with mixed feedback primarily related to the access and usage of technology. Cultural fit of the programme was acceptable. Youth mental health problems (η2=0.29) and family functioning significantly improved (η2=0.18) over the course of the programme. Unexpectedly, parent reports of youth attachment insecurity significantly worsened (η2=0.16).

Conclusions

The findings suggest that the online delivery ofConnectwas a promising way to reduce barriers to service access and improve mental health problems and family functioning among forcibly displaced parents and their children during COVID-19. Future research is needed to explore the acceptability and impact of this programme post-COVID-19, and to develop culturally tailored and psychometrically sound measures for parent and youth reports of attachment.
Sharpening celebrated convex inequalities with applications to operators and entropies
Authors: Sababheh Mohammad , Furuichi Shigeru , Moradi Hamid Reza
Published: August 2023

The Jensen, Jensen–Mercer, and Hermite–Hadamard inequalities have been key in advancing convex inequalities for scalars and operators, with several applications in fields like mathematical physics, operator theory and mathematical inequalities. This paper presents a new argument leading to interesting refinements of these celebrated inequalities. Applications that include entropy and operator inequalities will be presented.
Review on Processing Methods of Toxic Chinese Materia Medica and the Related Mechanisms of Action
Authors: Pan Lingyun , Wang Yingshu , Yue Lixia , Wang Nan , Xu Wen , Liao Xue , Wang Haiying , Xiu Yanfeng
Published: August 2023

Toxic Chinese materia medica (CMM) has both pharmacological activities and toxic effects. Based on thousands of years of experience in the application of CMMs, people have explored many practical processing methods of CMMs, also known as “Pao Zhi”, to reduce/control toxicity and preserve/enhance efficacy. Toxic CMMs have been used throughout China’s hospitals. Yet, the production and use of toxic CMM should be carried out in accordance with the Chinese pharmacopoeia (ChP) and the processing regulations formulated by the health administrative departments of provinces, autonomous regions, and municipalities directly under the Central Government. This paper summarizes the current understanding and awareness of toxicity and 45 toxic CMMs, the commonly used processing methods of toxic CMMs recorded in the 2020 edition of ChP, and the changes in the chemical component, toxicity, or efficacy profiles after processing. This review may provide useful information for the processing methods of toxic CMMs worldwide. We believe that with an in-depth study and understanding of toxic CMMs combined with a standardized application, the toxicity of CMMs will be predictable and controllable in the future.
Harmonic oscillator in the context of the extended uncertainty principle
Authors: Hamil Bilel , Lütfüoğlu Bekir Can , Hocine Ahmed
Published: August 2023

At large-scale distances where the space-time is curved due to gravity, a nonzero minimal uncertainty in the momentum, [Formula: see text], is being estimated to emerge. The presence of minimal uncertainty in momentum allows a modification to the quantum uncertainty principle, which is known as the extended uncertainty principle (EUP). In this work, we handle the harmonic oscillator problem in the EUP scenario and obtain analytical exact solutions in classical and semi-classical domains. In the classical context, we establish the equations of motion of the oscillator and show that the EUP-corrected frequency is depending on the energy and deformation parameter. In the semi-classical domain, we derive the energy eigenvalue levels and demonstrate that the energy spectrum depends on [Formula: see text], as the feature of hard confinement. Finally, we investigate the impact of the EUP on the harmonic oscillator’s thermodynamic properties by using the EUP-corrected partition functions in the classical limit in the (A)dS backgrounds.
Cubic auto-catalysis chemical reaction in non-Newtonian nanolubricant flow over a convectively heated rotating porous disk
Authors: Nagapavani M. , Venkata Ramana Reddy G. , Alsulami M. D.
Published: August 2023

This paper concerns with the numerical investigation on a boundary layer flow of nanolubricant/liquid flow over a convectively heated rotating disk. Following that, the research was supported by the inclusion of the convection process as well as the influence of heterogeneous and homogeneous reactions on the flow of the nanolubricant/liquid in concern. A comparative analysis is made in terms Zinc Oxide (ZnO)-Society of Automotive Engineers 50 nanolubricant and Zinc Oxide-Kerosene using two different models. Transforming the governing nonlinear equations yields the nonlinear ODE set. Numerical investigations use Runge–Kutta method. Flow, temperature and concentration field controlling factors are also explored numerically. The heat transport and shear stress and characteristics are evaluated for important factors. Results reveals that, ZnO-SAE50 nanolubricant shows augmented heat transport than ZnO-Kerosene nanoliquid for increased values of Q. But reverse trend is seen for increased Biot number values. Nanolubricant shows improved heat transport rate than ZnO-Kerosene nanoliquid for augmented values of heat source and porosity parameters.
Bioconvective flow of bi-viscous Bingham nanofluid subjected to Thompson and Troian slip conditions
Authors: Song Min , Puneeth V. , Sayed Hamed M. , Aly Emad H.
Published: August 2023

This paper describes the bioconvection phenomenon and its significant influence on the thermal features of the flow of bi-viscous Bingham (BVB) nanofluid past a vertically stretching flat surface. The analysis of the impact of convection parameters is considered along with various other forces. Meanwhile, the flow of BVB nanofluid is put through the slip conditions defined by Thompson and Troian for the velocity at the boundary. The flow of BVB nanofluid is modeled using the partial differential equations (PDEs) under the assumptions of thermophoresis and Brownian motion which occur due to the movement of nanoparticles. Along with these forces, the radiation is also considered so that the obtained results are close to the practical scenarios. Thus, using the proper Lie group similarity transformations, the intended mathematical model is converted into ordinary differential equations (ODEs). The resulting equation system is encoded using the RKF-45 technique, and the outcomes are explained using graphs and tables. The solutions found for the model showed that, for higher ranges of the non-Newtonian fluid parameter, the velocity decreases while the heat transferred by the nanofluid increases. The availability of motile density at the surface grows as the Péclet number rises, whereas the Schmidt numbers decline in their respective profiles.
Bilinear auto-Bäcklund transformations, breather and mixed lump–kink solutions for a (3+1)-dimensional integrable fourth-order nonlinear equation in a fluid
Authors: Meng Fan-Rong , Tian Bo , Zhou Tian-Yu
Published: August 2023

In this paper, we investigate a (3+1)-dimensional integrable fourth-order nonlinear equation that can model both the right- and left-going waves in a fluid. Based on the Hirota method, we derive three sets of the bilinear auto-Bäcklund transformations along with some analytic solutions. Through the extended homoclinic test approach, we obtain some breather solutions. We find that the breather propagates steadily along a straight line, with one hole and one peak in each period. Graphical investigation indicates that the coefficients in that equation affect the location and shape of the breather. Moreover, we construct some mixed lump–kink solutions. Fusion and fission between a lump wave and a kink soliton are analyzed graphically. The solutions addressed in this paper may be applied to mimic some complex waves in fluids.
Fractional computations for free convective flow of Casson-hybrid nanofluid flow with sodium alginate and water as based materials
Authors: Maatoug Samah , Al-Khaled Kamel , Raza Ali , Labidi Taher , Kolsi Lioua , Chammam Wathek , Almuqrin Muqrin , Khan Sami Ullah
Published: August 2023

The hybrid nanofluid is the modified class of nanomaterials with impressive thermal impact and preserves significant applications in extrusion systems, thermal management systems, engineering processes, cooling and heating materials and many more. The aim of this research is to communicate the thermal enhancement of water (H2O) and sodium alginate (C6H9NaO7) base fluids with interaction of hybrid nanofluids. The Casson fluid model is used to endorse the properties of such base liquids. The titanium dioxide and silver nanoparticles incorporate the thermal impact of hybrid nanofluid properties. The fractional simulations are performed by using the Caputo–Fabrizio (CF) time-fractional derivatives. The integration of problem is computed via Laplace technique. It is observed that the velocity profile enhanced the Grashof number. The increasing observations for Nusselt number and wall shear force due to fractional parameters are obtained.
Basin Entropy and Wada Property of Magnetic Field Line Escape in Toroidal Plasmas with Reversed Shear
Authors: Haerter P. , de Souza L. C. , Mathias A. C. , Viana R. L. , Caldas I. L.
Published: August 2023

The structure of magnetic field lines in toroidal fusion plasmas, as in tokamaks and stellarators, represents the lowest-order description of the plasma particle behavior, up to finite Larmor and drift effects. Tokamaks with reversed magnetic shear typically present internal transport barriers that help to improve confinement through a partial or total reduction of the particle transport across magnetic surfaces. In this work, we investigate numerically particle escape in tokamaks with reversed shear in order to identify fractal structures affecting transport. These structures are quantitatively evaluated using two basic measures: the basin entropy and the Wada property.
Fixed-/Preassigned-Time Stability Control of Chaotic Power Systems
Authors: Wang Leimin , Zhou Yu , Xu Da , Lai Qiang
Published: August 2023

A power system shows chaotic oscillation when it is subjected to periodic load disturbance, which makes it a challenging and interesting problem for stability control of chaotic power system. In this paper, a unified controller is designed to solve the fixed-time and preassigned-time stability problems of fourth-order chaotic power systems. In addition, based on Lyapunov stability theory, sufficient conditions are established for the fixed-time and preassigned-time stability of the underlying chaotic power systems, and a more accurate estimation of the settling time is also derived. Finally, according to numerical simulations, we validate the theoretical results.
Homoclinic Bifurcations in a Class of Three-Dimensional Symmetric Piecewise Affine Systems
Authors: Liu Ruimin , Liu Minghao , Wu Tiantian
Published: August 2023

Many physical and engineering systems have certain symmetric properties. Homoclinic orbits play an important role in studying the global dynamics of dynamical systems. This paper focuses on the existence and bifurcations of homoclinic orbits to a saddle in a class of three-dimensional one-parameter three-zone symmetric piecewise affine systems. Based on the analysis of the Poincaré maps, the systems have two types of limit cycles and do not have chaotic invariant sets near the homoclinic orbits. In addition, the paper provides a constant [Formula: see text] to study the homoclinic bifurcations to limit cycles for the case [Formula: see text]. Two examples with simulations of the homoclinic orbits and the limit cycles are given to illustrate the effectiveness of the results.
Investigation on growth, spectral, hardness, piezoelectric, contact angle, optical stress and nonlinear optical properties of acid blue 22 dye on ADP single crystals
Authors: Praveen B. , Saravanan M.
Published: August 2023

Reclusive single crystals of ammonium dihydrogen phosphate (ADP) and 0.1[Formula: see text]mol.% Acid Blue 22 dye-incorporated ADP were harvested by using a standard slow cooling mechanism. The skeletal framework of the anisotropic materials was analyzed by using single crystal X-ray diffraction cram. The powder X-ray diffraction examines the phase growth and incorporation of substituents in the crystalline matrices. The incorporation of additives in the system was examined by employing Fourier Transform Infrared Spectroscopy. The analysis of vibrational bands gives insights into the incorporation of additives in ADP crystal system. The transmission window of the specimen and optical bandgap of the given material were analyzed by using UV–Vis spectroscopic analysis. The incorporation of additives to parent crystals was examined by using Scanning Electron Microscope. The quantification of elements in the grown specimen was investigated by using Energy Dispersive X-ray spectroscopy. The mechanical rigidity of the material was inspected by using Vickers microhardness analysis. The piezoelectric charge coefficient of dye-incorporated ADP is higher than pristine ADP. The wettability of the material was identified by contact angle measurements. The optical stress was identified by employing photoelastic measurements. The second- and third-order nonlinear optical properties of pristine and dye-incorporated ADP crystals were investigated by using Kurtz–Perry powder technique and Z-scan technique.
An Ab-Initio Study on Mechanical Properties of Titanium Dioxide Single-Wall Nanotube
Authors: Asadpour M. , Sadeghi M. , Bani Asadi Bideshki A.
Published: August 2023

Titanium dioxide nanotubes (TiO2 NTs) exhibit superior biomechanical compatibility compared to artificial biomaterials. In this study, we employed density functional theory (DFT) calculations using the generalized gradient approximation (GGA) to determine the elastic-plastic regions and Young’s moduli of TiO2 NTs. Following the optimization process, our findings reveal that the Ti-O bond lengths differ depending on whether they are inside or outside bonds, ranging from 1.85 to 2.05 angstrom. Notably, TiO2 NTs demonstrate a low elastic modulus of approximately 29–38[Formula: see text]GPa when subjected to strains between −2% and 2% along the central axis of the nanotube. Regarding the elastic-plastic regions, the first critical point ([Formula: see text] is reached at around 20% strain for the (8,8) TiO2 NT, suggesting that it will transition out of the elastic region faster than the others under uniaxial strain. Additionally, the total density of state (DOS) analysis indicates that all of these structures exhibit semiconductor properties.
Fabrication, high-temperature mechanical behavior, and oxidation resistance of high entropy alloys: A review
Authors: Sun Aidong , Zhai Wenzheng , Fu Youheng , Hu Kelong , Yang Xuhui , Ke Jian , Liu Siyu , Lv Liang , Huang Min , Wang Guilang , Zhang Haiou
Published: August 2023

High entropy alloys (HEAs), as a new type of alloy, have attracted increasing attention since it was developed in 2004, showing high engineering potential in various fields. This paper provides a comprehensive review of the recent progress in their fabrication, high-temperature mechanical behavior, and oxidation resistance. It begins with an introduction of the effects of intrinsic characteristics of HEAs on their physical properties, focusing on the four typical effects including the high-entropy effect, the sluggish diffusion effect, the severe lattice effect, and the cocktail effect. Fabrication methods of HEA feeding powders, HEA blocks, and HEA coatings are then analyzed from the methodologies to mechanical properties. Afterward, the recent progress of FeCoCrNiAlTi HEAs and refractory HEAs which both demonstrated excellent mechanical properties at high temperatures is discussed with the underlying mechanisms, such as the chemical composition effect, the phase structure effect, and the strengthening effect. Recent antioxidant strategies including the formation of Al oxides, Cr oxides, and Si oxides in HEAs are highlighted. This review is concluded with prospects on challenges and future directions in the critical fields, such as their fundamental applications and design strategies of advanced HEAs with good high-temperature performance.
A Reduced Order Series Expansion for the BEM Incorporating the Boundary Layer Impedance Condition
Authors: Paltorp Mikkel , Henrìquez Vicente Cutanda , Aage Niels , Andersen Peter Risby
Published: August 2023

When modeling sound waves in fluids it can be important to include the viscous and thermal losses originating from the fluids’ interaction with boundaries. In the audible frequency range, the thickness of the boundary layers is between a micrometer and a millimeter. As such the viscous and thermal losses are important when simulating the properties of small acoustical devices such as e.g. hearing aids or transducers. However, the inclusion of viscous and thermal losses is a computationally demanding task as it requires a fine discretization of the boundary layer in order to fully capture the complicated physical phenomena happening on the microscale. Recently, there has been developments to ease the computational demands using both the Finite Element Method and the Boundary Element Method, by approximating the losses using the Boundary Layer Impedance (BLI) boundary condition. In this paper, we extend previous developments for multi-frequency analysis using the Reduced Order Series Expansion Boundary Element Method to handle the BLI condition. This model follows a two-step procedure: Using a series expansion to decrease the assembly time of the BEM matrices and a projection to reduce the overall memory consumption of the model. Results from two acoustic interior problems show that the model decreases the total computational time by around 96% while using less than 15% of the memory. For both test setups the limiting factor of the accuracy was the reduction and not the series expansion.
Towards the Internet of Living Trees for Precision Agriculture
Authors: Liller Jackson , Tran Trung , Nguyen Phuc "VP"
Published: August 2023

IoTree is a low-cost, low-maintenance, long-lived wearable sensing solution for monitoring the health of trees, providing fully autonomous renewable-energy collection and parameter sensing, compression, and transmission from over a mile away. The IoTree system is battery-free and operates on an opportunistic, block-based intermittent-computing paradigm; when the system is able to harvest enough energy via renewable sources, the LoRa controller will produce samples from the nutrient sensor and transmit the data to a base station for further analysis. Initial laboratory trials for IoTree demonstrate 91.08% and 90.51% accuracy in detecting ammonia and potassium oxide levels, respectively. Furthermore, a 30-day farm trial showed that the IoTree system could capture measurements regularly in the Grapevine farm deployment. IoTree is designed with open-source software, 3D models, and affordable off-the-shelf components, ensuring availability as a tool to educational institutes and hobbyists alike.
Using the Interval-Symbol Method with Zero Rewriting to Factor Polynomials over Algebraic Number Fields
Authors: Okuda Kazuki , Shirayanagi Kiyoshi
Published: August 2023

The ISZ method (Interval-Symbol method with Zero rewriting) based on stabilization theory was proposed to reduce the amount of exact computations as much as possible but obtain the exact results by aid of floating-point computations. In this paper, we applied the ISZ method to Trager's algorithm which factors univariate polynomials over algebraic number fields. By Maple experiments, we show the efficiency of the ISZ method over the purely exact approach which uses exact computations throughout the execution of the algorithm. Furthermore, we propose a new method called the ISZ* method, which is similar to the ISZ method but beforehand excludes insufficient precisions of floating-point approximation by checking the correctness of the obtained supports. We confirmed that the ISZ* method is more effective than the ISZ method when the initially set precision is not sufficiently high.
Operations for D-Algebraic Functions
Authors: Tabuguia Bertrand Teguia
Published: August 2023

A function is differentially algebraic (or simply D-algebraic) if there is a polynomial relationship between some of its derivatives and the indeterminate variable. Many functions in the sciences, such as Mathieu functions, the Weierstrass elliptic functions, and holonomic or D-finite functions are D-algebraic. These functions form a field, and are closed under composition, taking functional inverse, and derivation. We present implementation for each underlying operation. We also give a systematic way for computing an algebraic differential equation from a linear differential equation with D-finite function coefficients.

Each command is a feature of our Maple package NLDE available at https://mathrepo.mis.mpg.de/DAlgebraicFunctions/NLDEpackage.
The Fifth Conference "Computer Algebra" in Moscow
Authors: Abramov Sergei A. , Batkhin Alexander B. , Ryabenko Anna , Sevastianov Leonid A. , Zonn Yvette , Wu Min
Published: August 2023

The fifth International Conference "Computer algebra" http://www.ccas.ru/ca/conference is organized in Moscow from 26 to 28 June 2023 jointly by the Dorodnicyn Computing Centre (Federal Research Center "Computer Science and Control") of Russian Academy of Science, the Russian University of Peoples' Friendship named after Patrice Lumumba and Keldysh Institute of Applied Mathematics of Russian Academy of Sciences.
Hydrochemical Characterization and Water Quality Assessment for Drinking and Irrigation Purposes Using WQI and GIS Techniques in the Upper Omo River Basin, Southern Ethiopia
Authors: Tesema Adimasu , Jothimani Muralitharan , Abebe Abel , Gunalan Jagadeshan , Getahun Ephrem , Karuppannan Shankar
Published: August 2023

Groundwater is an important source of drinking water and irrigation in Ethiopia’s present study area of the upper Omo River catchment. The present study area has an increasing demand for high-quality groundwater. Extensive irrigation and urban expansion are ongoing in the study area, seriously compromising groundwater quality. A study was conducted in Ethiopia’s upper Omo River catchment to assess groundwater’s suitability for drinking water and agricultural purposes. In total, 58 water samples were collected for this study. Based on the WHO and Ethiopian standards for assessing water quality, the study’s results have been analyzed and compared. The groundwater’s primary ion and physicochemical properties were plotted using GIS technology. Based on the results of the hydrochemical analysis, three water quality index (WQI) zones were identified: excellent (58.82%), good (35.29%), and poor (5.88%). From the Piper diagram plots, five different types of water were identified as Ca-HCO3, Na-HCO3, mixed Ca-Na-HCO3, NaCl, and CaCl, out of the total of fifty-eight samples collected from the study area. The present study found that in the area, most water samples are suitable for drinking, except for a few parameters above the standards for drinking water set by the World Health Organization and Ethiopian drinking water quality standards. Except for the three samples, EC, SAR, and PI data indicate that most of the area’s water samples are suitable for irrigation. Water quality indices, irrigation water quality methods, and GIS techniques are crucial for assessing water quality based on the study.
The Role of Social Support and Socioeconomic Factors in the Prediction of Depression among First-Year Undergraduate Students
Authors: Sadeghi Razieh , Ghandehari Alavijeh Maedeh , Raeisi Shahraki Hadi
Published: August 2023

Aim. This study was devoted to determining the role of social support and socioeconomic factors in predicting students’ depression. Methods. In this cross-sectional study, all first-year undergraduate students in the Shahrekord University of Medical Sciences, Iran, during the 2019-2020 academic year were included via the census method. Data collection tools include a researcher-made checklist about demographic and socioeconomic status, a standard questionnaire of perceived social support, and Beck’s depression questionnaire. Smoothly clipped absolute deviation (SCAD) linear regression was used to model the role of social support and socioeconomic factors in predicting depression. Results. Out of the 220 first-year undergraduate students, 174 (79.1%) were female, and 176 (80.0%) were single. The

mean
±
SD

of depression score among the first-year undergraduate students was

10.56
±
5.19

, and the

mean
±
SD

of social support score was

48.86
±
5.46

. The mean score of depression was significantly higher in female students than in males (11.09 versus 8.59,

P
=
0.001

) but was not statistically significant in different categories of age (

P
=
0.70

), marital status (

P
=
0.37

), ethnicity (

P
=
0.10

), parents’ education, and the other demographic variables. Pearson’s correlation showed an inverse and significant correlation between depression and social support (

R
=
−
0.20

,

P
=
0.003

). The mean score of depression was at the highest level for students of public health and environmental health majors and was the lowest for students of laboratory sciences, which was statistically significant (

P
<
0.001

). After adjusting the other variables, SCAD regression showed that social support plays a key role in depression prediction, and increasing social support leads to a decrease in depression score. Conclusion. Considering the existence of an inverse and significant correlation between depression and social support, any intervention to promote social support for first-year undergraduate students may decrease depression.
Lymphocyte-Rich Hepatocellular Carcinoma with Multiple Lymphadenopathy and Positive Epstein–Barr Virus Encoding Region
Authors: Wang Pin-Yi , Kuo Yu-Hsuan , Sheu Ming-Jen , Kuo Hsing-Tao , Lee Wen-Ying , Kuo Yu-Ting , Wang Su-Hung
Published: August 2023

Lymphocyte-rich hepatocellular carcinoma (HCC) represents the rarest subtype among the various subgroups of HCC, and limited clinical data are available for this particular subtype. It is commonly observed as a solitary lesion and tends to present at an early stage. Histopathological examination typically reveals tumor cells infiltrated by a lymphocyte-rich background, leading to its designation as lymphoepithelioma-like HCC. Unlike other lymphoepithelioma-like tumors associated with the Epstein–Barr virus (EBV), lymphocyte-rich HCC is predominantly negative for EBV. This subtype is characterized by more favorable clinical outcomes and prognosis compared to conventional HCC. Here, we present a case of lymphocyte-rich hepatocellular carcinoma (HCC) characterized by the presence of bilateral hepatic tumors and concurrent multiple lymphadenopathy. Interestingly, contrary to previous literature, the examination for the Epstein–Barr virus (EBV) revealed a positive result in this particular case.
Parametric Damping of Microgrid Frequency Fluctuations at Synchronous Machines with Using Lyapunov Theory for Exciter Regulation
Authors: Petrík Tomáš , Gravalos Ioannis , Uhlíř Ivan , Libra Martin , Poulek Vladislav
Published: August 2023

In synchronous machines, electromechanical swinging can be damped by parametric control of the excitation current. This is possible only in case the excitation time constant is much smaller than the mechanical constant of the machine. The method described in this paper is effective for damping oscillations caused by oscillations in the grid frequency, grid voltage, and mechanical torque fluctuations. The method is based on the Lyapunov stability theory and demonstrated on a real synchronous machine. This machine operates as a noninterruptible backup power system. The original power fluctuations were up to 50% of the nominal power of the machine. With the described control, a sevenfold increase in the damping of fluctuations caused by grid frequency variations has been achieved.
Paclitaxel Induces Neurotoxicity by Disrupting Tricarboxylic Acid Cycle Metabolic Balance in the Mouse Hippocampus
Authors: Liu Xi , Cui Changmeng , Sun Wenxue , Meng Junjun , Guo Jinxiu , Wu Linlin , Chen Beibei , Liao Dehua , Jiang Pei
Published: August 2023

Objective. It is well known that paclitaxel (PTX)-induced neurotoxicity seriously affects the quality of life of patients and is the main reason for reducing the dose of chemotherapy or even stopping chemotherapy. The current data are limited, and further information is required for practice and verification. The aims of this study were to clarify the molecular mechanism underlying PTX-induced neurotoxicity by combining in vivo and in vitro metabolomics studies and provide new targets for the prevention and treatment of PTX-induced neurotoxicity. Methods. In the in vivo study, a PTX-induced neurotoxicity mouse model was established by intraperitoneal injection of PTX (6 mg/kg every three days) for two consecutive weeks. After verification by water maze tests and HE staining of pathological sections, hippocampal metabolites were measured and the differential metabolites and related metabolic pathways were identified by multivariate statistical analysis. In the in vitro study, we investigated the effects of PTX on mouse hippocampal neuron cells, assessing the concentration and time of administration by MTT assays. After modeling, the relevant metabolites in the TCA cycle were quantified by targeted metabolomics using stable isotope labeling. Finally, the key enzymes of the TCA cycle in tissues and cells were verified by RT-PCR. Results. Administration of PTX to model mice resulted in neurological damage, shown by both water-maze tests and hippocampal tissue sections. Twenty-four metabolites and five associated metabolic pathways were found to differ significantly between the hippocampal tissues of the model and control groups. These included metabolites and pathways related to the TCA cycle and pyruvate metabolism. Metabolomics analysis using stable isotope labeling showed significant changes in metabolites associated with the TCA cycle compared with the control group (

P
<
0.05

). Finally, RT-PCR verified that the expression of key enzymes in the TCA cycle was changed to different degrees in both hippocampal tissues and cells. Conclusion. Our results showed that PTX neurotoxicity in hippocampal tissue and neuron cells was associated with inhibition of the TCA cycle. This inhibition leads to brain insufficiency and impaired metabolism, resulting in various neurotoxic symptoms.
The Effect of Metabolic Persian Diet on Ovulation Induction in Infertile Women
Authors: Jamebozorg Nasrin , Ghaffari Farzaneh , Alijaniha Fatemeh , Karimi Yasin , Mohammad Beigi Robabeh , Haghani Hamid , Naseri Mohsen , Neisani Samani Leila
Published: August 2023

Introduction. Infertility is an important issue with a high social and psychological burden. From the perspective of Persian Medicine (PM), uterine cold temperament is one of the important causes of female infertility. Aim. The aim of this study was to study the effect of PM or Iranian traditional medicine on improving ovulation and fertility. Methods. From January 2017 to August 2017, sixty infertile women with eugonadotropic ovulation disorder were randomly divided into two groups. Both groups were treated with clomiphene citrate, except that the intervention group also received metabolic Persian diet (MPD). In each cycle, the dominant follicles and endometrium were investigated with ultrasound. At the end of the cycle, beta human chorionic gonadotropin (β-HCG) was evaluated and if positive, another ultrasound was performed two weeks later to confirm early pregnancy. Results. The number of dominant follicles from the first to third cycle increased from 2.15 ± 1.14 to 2.28 ± 0.61 in the intervention group and decreased from 1.86 ± 0.79 to 1.30 ± 0.47 in the control group. The dominant follicle size changed from 16.00 ± 4.08 to 18.78 ± 2.78 and from 15.05 ± 3.11 to 15.80 ± 3.89 in the intervention and control groups, respectively. But endometrial thickness did not change significantly in the intervention group. Pregnancy results based on β-HCG and ultrasound findings were positive in 19 and 16 patients in the intervention group and in 10 and 7 patients in the control group, implying significantly higher numbers in the first group. Conclusion. It seems that MPD may be effective in the success of ovulation induction.
Natural Anthraquinones as Promising MAPK3 Inhibitors for Complementary Cancer Therapy
Authors: Vaziri-Amjad Samaneh , Moradi-Najmi Massoud , Taherkhani Amir
Published: August 2023

Objective. MAPK3 activates several nuclear transcription factors, including c-Jun and c-fos, by phosphorylating its downstream cytoplasmic protein, thereby contributing to cell proliferation and survival. Different carcinomas’ initiation, progression, cancer cell metastasis, and drug resistance have been associated with MAPK3 overexpression. Given the need for new and potent MAPK3 inhibitors, this study aimed to explore the potential of anthraquinones (AQs) as organic compounds capable of inhibiting MAPK3. Methods. Using AutoDock 4.0 software, the binding affinity of 21 AQs to the receptor’s active site was evaluated. AQs were ranked based on their ΔGbinding values to the receptor’s active site, with the highest rankings receiving the most favorable scores. The Discovery Studio Visualizer tool was used to demonstrate the interaction modes between the highest-ranked AQs and the MAPK3 catalytic site. Furthermore, a 100-nanosecond molecular dynamics (MD) computer simulation was performed to assess the stability of the docked pose of the most potent enzyme inhibitor identified in this study. Results. The binding affinity of emodin-8-glucoside, aloe-emodin 8-glucoside, pulmatin, rhodoptilometrin, and hypericin to the receptor’s ATP binding cleft was noteworthy, as the ΔGbinding values were < 

−

10 kcal/mol. In addition, emodin-8-glucoside, aloe-emodin 8-glucoside, and pulmatin were found to have inhibition constant values at the picomolar concentration. According to our computer simulation results, the docked pose of emodin-8-glucoside within the active site of MAPK3 achieved a stable state after 70 ns. In other words, the root mean square deviation (RMSD) graph indicated stability within the 70–100 ns timeframe. Conclusion. Inhibition of MAPK3 by emodin-8-glucoside, aloe-emodin 8-glucoside, pulmatin, rhodoptilometrin, and hypericin may have therapeutic potential in cancer treatment.
Supplementary Table S4 from Whole genome CpG-resolution DNA methylation profiling of HNSCC reveals distinct mechanisms of carcinogenesis for fine-scale HPV+ cancer subtypes
Authors: Qin Tingting , Li Shiting , Henry Leanne E , Chou Elysia , Cavalcante Raymond G , Garb Bailey F , D'Silva Nisha J. , Rozek Laura S. , Sartor Maureen A
Published: August 2023

Supplementary Table S4- TFs and their ChIP-seq peak sets used
Supplementary Table S1 from Whole genome CpG-resolution DNA methylation profiling of HNSCC reveals distinct mechanisms of carcinogenesis for fine-scale HPV+ cancer subtypes
Authors: Qin Tingting , Li Shiting , Henry Leanne E , Chou Elysia , Cavalcante Raymond G , Garb Bailey F , D'Silva Nisha J. , Rozek Laura S. , Sartor Maureen A
Published: August 2023

Supplemental Table S1- Summary of differentially methylated regions
Supplementary Table S2 from Development and validation of a 15-gene expression signature with superior prognostic ability in stage II colorectal cancer
Authors: Rokavec Matjaž , Özcan Elif , Neumann Jens , Hermeking Heiko
Published: August 2023

Supplementary Table S2 shows a subset of 61 genes that were highly significantly associated with survival in CRC patient cohorts.
Supplementary Video V1 from Exploring the Onset and Progression of Prostate Cancer through a Multicellular Agent-based Model
Authors: Passier Margot , van Genderen Maisa N.G. , Zaalberg Anniek , Kneppers Jeroen , Bekers Elise M. , Bergman Andries M. , Zwart Wilbert , Eduati Federica
Published: August 2023

Supplementary Video V1
FIGURE 7 from Exploring the Onset and Progression of Prostate Cancer through a Multicellular Agent-based Model
Authors: Passier Margot , van Genderen Maisa N.G. , Zaalberg Anniek , Kneppers Jeroen , Bekers Elise M. , Bergman Andries M. , Zwart Wilbert , Eduati Federica
Published: August 2023

Clinical validation of model predictions for different patient groups. A, Correlation between the simulated tumor growth (simulation time 400 days, 40 simulations per modeled patient group) and the average PFS time for clinical patients assigned to the matching patients groups based on molecular markers. Colors correspond to those used in Fig. 6B, portraying simulated tumor growth over time of the same classes. B, Binary Gleason scores per patient group; Gleason scores of 8 or higher were considered “high” and Gleason scores of 6 or lower were considered “low”.