bluuebunny/crossref_metadata_2025 huggingface dataset:
Work‐injury absence and compensation among partnered and lone mothers and fathers
Authors: Wong Imelda S. , Smith Peter M. , Mustard Cameron A. , Gignac Monique A. M.
Published: June 2014

Background

The purpose of this study is to examine the risk of a work‐injury absence and the likelihood of receiving compensation among partnered and lone mothers and fathers.

Methods

This study utilized data from an annual survey of Canadian residents. Logistic regression models examined the association between family status and the receipt of workers' compensation, and absences due to work‐related injury or illnesses of 7 or more days.

Results

Being a lone mother was significantly associated with the risk of work‐injury absence. Gender differences were observed for workers' compensation: mothers were half as likely as fathers to receive workers' compensation benefits, which may be attributed to differences in work experiences between men and women.

Conclusions

Findings may help in understanding whether some parental situations are more vulnerable than others and may contribute to identifying policies that could help workers sustain employment or return to work following an injury. Am. J. Ind. Med. 57:960–969, 2014. © 2014 Wiley Periodicals, Inc.
Diamond–Blackfan anemia with mandibulofacial dystostosis is heterogeneous, including the novel DBA genes TSR2 and RPS28
Authors: Gripp Karen W. , Curry Cynthia , Olney Ann Haskins , Sandoval Claudio , Fisher Jamie , Chong Jessica Xiao‐Ling ,   UW Center for Mendelian Genomics, Pilchman Lisa , Sahraoui Rebecca , Stabley Deborah L. , Sol‐Church Katia
Published: June 2014

Patients with physical findings suggestive of Treacher Collins syndrome (TCS) or mandibulofacial dysostosis (MFD) and macrocytic anemia diagnostic of Diamond–Blackfan anemia (DBA) have been reported. Disease‐causing genes have been identified for TCS and other MFDs. Mutations in several ribosomal protein genes and the transcription factor GATA1 result in DBA. However, no disease‐causing mutation had been identified in the reported patients with the combination of TCS/MFD and DBA phenotype, and we hypothesized that pathogenic mutations in a single gene could be identified using whole exome analysis. We studied probands from six unrelated families. Combining exome analysis and Sanger sequencing, we identified likely pathogenic mutations in 5/6 families. Two mutations in unrelated families were seen in RPS26, the known DBA10 gene. One variant was predicted to affect mRNA splicing, and the other to lead to protein truncation. In another family a likely pathogenic X‐linked mutation affecting a highly conserved residue was found in TSR2, which encodes a direct binding partner of RPS26. De novo mutations affecting the RPS28 start codon were found in two unrelated probands, identifying RPS28 as a novel disease gene. We conclude that the phenotype combining features of TCS with DBA is genetically heterogeneous. Each of the pathogenic variants identified is predicted to impede ribosome biogenesis, which in turn could result in altered cell growth and proliferation, causing abnormal embryologic development, defective erythropoiesis and reduced growth. The phenotype combining TCS/MFD and DBA is highly variable, overlaps with DBA and lies within the phenotypic spectrum of ribosomopathies. © 2014 Wiley Periodicals, Inc.
Radical S‐Adenosyl Methionine Epimerases: Regioselective Introduction of Diverse D‐Amino Acid Patterns into Peptide Natural Products
Authors: Morinaka Brandon I. , Vagstad Anna L. , Helf Maximilian J. , Gugger Muriel , Kegler Carsten , Freeman Michael F. , Bode Helge B. , Piel Jörn
Published: June 2014

PoyD is a radical S‐adenosyl methionine epimerase that introduces multiple D‐configured amino acids at alternating positions into the highly complex marine peptides polytheonamide A and B. This novel post‐translational modification contributes to the ability of the polytheonamides to form unimolecular minimalistic ion channels and its cytotoxic activity at picomolar levels. Using a genome mining approach we have identified additional PoyD homologues in various bacteria. Three enzymes were expressed in E. coli with their cognate as well as engineered peptide precursors and shown to introduce diverse D‐amino acid patterns into all‐L peptides. The data reveal a family of architecturally and functionally distinct enzymes that exhibit high regioselectivity, substrate promiscuity, and irreversible action and thus provide attractive opportunities for peptide engineering.
Rhodium‐Catalyzed Asymmetric Hydrogenation of Unprotected NH Imines Assisted by a Thiourea
Authors: Zhao Qingyang , Wen Jialin , Tan Renchang , Huang Kexuan , Metola Pedro , Wang Rui , Anslyn Eric V. , Zhang Xumu
Published: June 2014

Asymmetric hydrogenation of unprotected NH imines catalyzed by rhodium/bis(phosphine)‐thiourea provided chiral amines with up to 97 % yield and 95 % ee. 1H NMR studies, coupled with control experiments, implied that catalytic chloride‐bound intermediates were involved in the mechanism through a dual hydrogen‐bonding interaction. Deuteration experiments proved that the hydrogenation proceeded through a pathway consistent with an imine.
A De Novo Designed Metalloenzyme for the Hydration of CO2
Authors: Cangelosi Virginia M. , Deb Aniruddha , Penner‐Hahn James E. , Pecoraro Vincent L.
Published: June 2014

Protein design will ultimately allow for the creation of artificial enzymes with novel functions and unprecedented stability. To test our current mastery of nature’s approach to catalysis, a ZnII metalloenzyme was prepared using de novo design. α3DH3 folds into a stable single‐stranded three‐helix bundle and binds ZnII with high affinity using His3O coordination. The resulting metalloenzyme catalyzes the hydration of CO2 better than any small molecule model of carbonic anhydrase and with an efficiency within 1400‐fold of the fastest carbonic anhydrase isoform, CAII, and 11‐fold of CAIII.
A 2,6‐Bis(phenylamino)pyridinato Titanium Catalyst for the Highly Regioselective Hydroaminoalkylation of Styrenes and 1,3‐Butadienes
Authors: Dörfler Jaika , Preuß Till , Schischko Alexandra , Schmidtmann Marc , Doye Sven
Published: June 2014

The CC bond forming catalytic hydroaminoalkylation of terminal alkenes, 1,3‐dienes, or styrenes allows a direct and highly atom efficient (100 %) synthesis of amines which can result in the formation of two regioisomers, the linear and the branched product. We present a new titanium catalyst with 2,6‐bis(phenylamino)pyridinato ligands for intermolecular hydroaminoalkylation reactions of styrenes and 1‐phenyl‐1,3‐butadienes that delivers the corresponding linear hydroaminoalkylation products with excellent regioselectivities.
Copper‐Catalyzed One‐Pot Trifluoromethylation/Aryl Migration/Carbonyl Formation with Homopropargylic Alcohols
Authors: Gao Pin , Shen Yong‐Wen , Fang Ran , Hao Xin‐Hua , Qiu Zi‐Hang , Yang Fan , Yan Xiao‐Biao , Wang Qiang , Gong Xiang‐Jun , Liu Xue‐Yuan , Liang Yong‐Min
Published: June 2014

A novel copper‐catalyzed one‐pot functionalization of homopropargylic alcohols that involves trifluoromethylation, aryl migration, and formation of a carbonyl moiety has been developed. This reaction constitutes the first direct conversion of homopropargylic alcohols into CF3‐containing 3‐butenal or 3‐buten‐1‐one derivatives in a regioselective manner. Mechanistic studies indicate that the 1,4‐aryl migration proceeds through a radical pathway.
Ordered and Kinetically Discrete Sequential Protein Release from Biodegradable Thin Films
Authors: Hsu Bryan B. , Jamieson Kelsey S. , Hagerman Samantha R. , Holler Eggehard , Ljubimova Julia Y. , Hammond Paula T.
Published: June 2014

Multidrug regimens can sometimes treat recalcitrant diseases when single‐drug therapies fail. Recapitulating complex multidrug administration from controlled release films for localized delivery remains challenging because their release kinetics are frequently intertwined, and an initial burst release of each drug is usually uncontrollable. Kinetic control over protein release is demonstrated by cross‐linking layer‐by‐layer films during the assembly process. We used biodegradable and naturally derived components and relied on copper‐free click chemistry for bioorthogonal covalent cross‐links throughout the film that entrap but do not modify the embedded protein. We found that this strategy restricted the interdiffusion of protein while maintaining its activity. By depositing a barrier layer and a second protein‐containing layer atop this construct, we generated well‐defined sequential protein release with minimal overlap that follows their spatial distribution within the film.
Cavitand‐Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water
Authors: Biavardi Elisa , Federici Stefania , Tudisco Cristina , Menozzi Daniela , Massera Chiara , Sottini Andrea , Condorelli Guglielmo G. , Bergese Paolo , Dalcanale Enrico
Published: June 2014

The direct, clean, and unbiased transduction of molecular recognition into a readable and reproducible response is the biggest challenge associated to the use of synthetic receptors in sensing. All possible solutions demand the mastering of molecular recognition at the solid–liquid interface as prerequisite. The socially relevant issue of screening amine‐based illicit and designer drugs is addressed by nanomechanical recognition at the silicon–water interface. The methylamino moieties of different drugs are all first recognized by a single cavitand receptor through a synergistic set of weak interactions. The peculiar recognition ability of the cavitand is then transferred with high fidelity and robustness on silicon microcantilevers and harnessed to realize a nanomechanical device for label‐free detection of these drugs in water.
Evidence of a Kinetic Isotope Effect in Nanoaluminum and Water Combustion
Authors: Tappan Bryce C. , Dirmyer Matthew R. , Risha Grant A.
Published: June 2014

The normally innocuous combination of aluminum and water becomes violently reactive on the nanoscale. Research in the field of the combustion of nanoparticulate aluminum has important implications in the design of molecular aluminum clusters, hydrogen storage systems, as well as energetic formulations which could use extraterrestrial water for space propulsion. However, the mechanism that controls the reaction speed is poorly understood. While current models for micron‐sized aluminum water combustion reactions place heavy emphasis on diffusional limitations, as reaction scales become commensurate with diffusion lengths (approaching the nanoscale) reaction rates have long been suspected to depend on chemical kinetics, but have never been definitely measured. The combustion analysis of nanoparticulate aluminum with H2O or D2O is presented. Different reaction rates resulting from the kinetic isotope effect are observed. The current study presents the first‐ever observed kinetic isotope effect in a metal combustion reaction and verifies that chemical reaction kinetics play a major role in determining the global burning rate.
Lidar Investigation of Knockdhu Promontory and its Environs, County Antrim, Northern Ireland
Authors: McNeary Rory W. A.
Published: June 2014

A high‐resolution aerial lidar survey (up to 40 points m‐2) has been carried out in the environs of Knockdhu Promontory in the Antrim Uplands, which is recognized as one of Northern Ireland's most important relict multiperiod archaeological landscapes. This lidar survey was amongst the first such surveys commissioned specifically for archaeological purposes in Northern Ireland and has helped to re‐evaluate the archaeological landscape character of a 9 km2 study area and inform future conservation studies. Sampled ground observation was undertaken in an attempt to provide a higher degree of interpretive integrity. These field observation exercises also highlighted the importance of the high vertical resolution of the data (0.05 m at 2σ (95% confidence level)) in delineating extremely subtle upstanding earthwork features that had hitherto gone unnoticed. Much of the archaeological evidence identified can be broadly ascribed to the early post‐medieval period (ad 1599–1750); this includes field boundaries, cultivation furrows, enclosures, transhumance huts, abandoned settlements and associated pathways, but the higher ground of the Antrim Plateau in this locality is also characterized by evidence of prehistoric activities and substantial earthworks survive such as the ‘Linford Barrows’ and ‘Knockdhu Promontory Fort’. The lidar study has identified as many as 285 previously unrecorded potential archaeological sites and amended existing records within the Northern Ireland Sites and Monuments Record (NISMR) and has proved transformational as a technique to ‘open up’ the Ulster uplands for archaeological study. Copyright © 2014 John Wiley & Sons, Ltd.
Macrophage‐Derived Delta‐like Protein 1 Enhances Interleukin‐6 and Matrix Metalloproteinase 3 Production by Fibroblast‐like Synoviocytes in Mice With Collagen‐Induced Arthritis
Authors: Sekine Chiyoko , Nanki Toshihiro , Yagita Hideo
Published: June 2014

Objective

We previously reported that blockade of the Notch ligand delta‐like protein 1 (DLL‐1) suppressed osteoclastogenesis and ameliorated arthritis in a mouse model of rheumatoid arthritis (RA). However, the mechanisms by which joint inflammation were suppressed have not yet been revealed. This study was undertaken to determine whether DLL‐1 regulates the production of RA‐related proinflammatory cytokines.

Methods

Joint cells from mice with collagen‐induced arthritis (CIA) and mouse fibroblast‐like synoviocytes (FLS) were cultured with or without stimuli in the presence of neutralizing antibodies against Notch ligands, and the production of proinflammatory cytokines was determined by enzyme‐linked immunosorbent assay. The expression of Notch receptors and ligands on mouse joint cells was determined by flow cytometry.

Results

The production of interleukin‐6 (IL‐6) and granulocyte–macrophage colony‐stimulating factor (GM‐CSF) by mouse joint cells with or without stimulation was suppressed by DLL‐1 blockade. DLL‐1 blockade also suppressed the levels of IL‐6 and matrix metalloproteinase 3 (MMP‐3) in the joint fluid in a mouse model of RA. However, the production of tumor necrosis factor α and IL‐1β was not suppressed by DLL‐1 blockade. The production of IL‐6 and MMP‐3 by mouse FLS was enhanced by DLL‐1 stimulation as well as Notch‐2 activation. Among joint cells, DLL‐1 was not expressed on mouse FLS but was expressed on macrophages.

Conclusion

These results suggest that the interaction of DLL‐1 on mouse joint macrophages with Notch‐2 on mouse FLS enhances the production of IL‐6 and MMP‐3. Therefore, suppression of IL‐6, GM‐CSF, and MMP‐3 production by DLL‐1 blockade might be responsible for the amelioration of arthritis in a mouse model of RA.
Citrullination of Epithelial Neutrophil–Activating Peptide 78/CXCL5 Results in Conversion From a Non–Monocyte‐Recruiting Chemokine to a Monocyte‐Recruiting Chemokine
Authors: Yoshida Ken , Korchynskyi Olexandr , Tak Paul P. , Isozaki Takeo , Ruth Jeffrey H. , Campbell Phillip L. , Baeten Dominique L. , Gerlag Danielle M. , Amin M. Asif , Koch Alisa E.
Published: June 2014

Objective

To examine whether the citrullinated chemokines epithelial neutrophil–activating peptide 78 (ENA‐78)/CXCL5, macrophage inflammatory protein 1α/CCL3, and monocyte chemotactic protein 1/CCL2 are detected in the biologic fluid of patients with rheumatoid arthritis (RA), and if so, to determine the biologic activities of these chemokines.

Methods

Recombinant human chemokines were citrullinated by peptidylarginine deiminase. Enzyme‐linked immunosorbent assays were performed to measure the concentrations of citrullinated chemokines in sera from patients with rheumatoid arthritis (RA) and normal individuals and in synovial fluid from patients with RA, patients with osteoarthritis (OA), and patients with other inflammatory rheumatic diseases. The correlation between the citrullinated chemokine levels and clinical data was analyzed. Monocyte and neutrophil chemotaxis assays were performed, and native (noncitrullinated) or citrullinated ENA‐78/CXCL5 was injected into mouse knees to evaluate the biologic activities of these chemokines.

Results

The concentration of citrullinated ENA‐78/CXCL5 was significantly higher in RA sera and SF than in normal sera and in SF from patients with other rheumatic diseases including OA. In RA SF, a strong correlation between the amount of citrullinated ENA‐78/CXCL5 and the C‐reactive protein level or the erythrocyte sedimentation rate was observed. Citrullinated ENA‐78/CXCL5 induced monocyte chemotaxis via CXCR1 and CXCR2, while noncitrullinated ENA‐78/CXCL5 did not. In a mouse model of inflammatory arthritis, citrullinated ENA‐78/CXCL5 induced more severe inflammation and recruited more monocytes than did noncitrullinated ENA‐78/CXCL5.

Conclusion

Citrullinated ENA‐78/CXCL5 is highly correlated with RA disease activity and, unlike noncitrullinated ENA‐78/CXCL5, recruits monocytes. These results indicate that citrullinated ENA‐78/CXCL5 may exert previously unrecognized inflammatory properties in RA by recruiting monocytes to inflamed joint tissue.
Sequence‐Specific DNA Alkylation by Tandem Py–Im Polyamide Conjugates
Authors: Taylor Rhys Dylan , Kawamoto Yusuke , Hashiya Kaori , Bando Toshikazu , Sugiyama Hiroshi
Published: June 2014

Tandem N‐methylpyrroleN‐methylimidazole (PyIm) polyamides with good sequence‐specific DNA‐alkylating activities have been designed and synthesized. Three alkylating tandem PyIm polyamides with different linkers, which each contained the same moiety for the recognition of a 10 bp DNA sequence, were evaluated for their reactivity and selectivity by DNA alkylation, using high‐resolution denaturing gel electrophoresis. All three conjugates displayed high reactivities for the target sequence. In particular, polyamide 1, which contained a β‐alanine linker, displayed the most‐selective sequence‐specific alkylation towards the target 10 bp DNA sequence. The tandem PyIm polyamide conjugates displayed greater sequence‐specific DNA alkylation than conventional hairpin PyIm polyamide conjugates (4 and 5). For further research, the design of tandem PyIm polyamide conjugates could play an important role in targeting specific gene sequences.
New strategy for expression of recombinant hydroxylated human collagen α1(III) chains in Pichia pastorisGS115
Authors: He Jing , Ma Xiaoxuan , Zhang Fenglong , Li Linbo , Deng Jianjun , Xue Wenjiao , Zhu Chenhui , Fan Daidi
Published: June 2014

Type III collagen is one of the most abundant proteins in the human body, which forms collagen fibrils and provides the stiff, resilient characteristics of many tissues. In this paper, a new method for secretory expression of recombinant hydroxylated human collagen α1(III) chain in Pichia pastoris GS115 was applied. The gene encoding for full‐length human collagen α1(III) chain (COL3A1) without N‐terminal propeptide and C‐terminal propeptide was cloned in the pPIC9K expression vector. The prolyl 4‐hydroxylase (P4H, EC 1.14.11.2) α‐subunit (P4Hα) and β‐subunit (P4Hβ) genes were cloned in the same expression vector, pPICZB. Fluorogenic quantitative PCR indicates that COL3A1 and P4H genes have been expressed in mRNA level. SDS‐PAGE shows that secretory expression of recombinant human collagen α1(III) chain was successfully achieved in P. pastoris GS115. In addition, the result of amino acids composition analysis shows that the recombinant human collagen α1(III) chain contains hydroxyproline by coexpression with the P4H. Furthermore, liquid chromatography coupled with tandem mass spectrometry analysis demonstrates that proline residues of the recombinant human collagen α1(III) chain were hydroxylated in the X or Y positions of Gly–X–Y triplets.
Was zählt der Preis? Dogmengeschichte und Wissensgeschichte der Ökonomie
Authors: Speich Chassé Daniel
Published: June 2014

What’s in a Price? History of Economic Ideologies vs. History of Economic Ideas. This paper suggests applying the approach of a historical epistemology to the field of economics. We observe that an assumedly fundamental opposition between the market and the state dominates popular images of the history of economic ideas. Two conflicting ideologies are roughly assigned to the two opposing sides in the Cold War. To this historical narrative the paper opposes a different view. The argument is that when taking the technical practices of economic knowledge production in the twentieth century into view, similarities abound across ideological ruptures. The chief characteristic change in the recent history of economics was a radical turn towards quantification, measurement, and mathematical modelling. A historical epistemology of economics could show how deeply both, admirers of the state and of the market, share a history. The paper concludes that to‐date critique of political economy should also take into consideration a critical perspective towards the unfolding of this measurement revolution in the social sciences.
Kommentar: The Economic or the Economy? – Reflections on the Objects of Historical Epistemology
Authors: Tellmann Ute
Published: June 2014

In the recent decade the perspectives of historical epistemology have turned economic practices into a novel object of study: the focus lies on how discourses, techniques of measurement and valuation produce economic facts.1 The research on the historical epistemologies of economic facts belongs to a broader scholarly endeavor that takes place in cultural anthropology, social theory, literary studies, political theory and history. This interdisciplinary work brings to light how deeply economic issues are constituted by intermingling a set of cultural, political, technical and legal distinctions, which distinguish what counts as properly economic from what does not.2 In this perspective, the very definition of economy becomes a hybrid and contentious affair.

The central theoretical question for the historical epistemology and cultural anthropology of economy is currently how to conceptualize the link between epistemic practices and acts of ‘doing the economy’. This special issue on the Historical Episte mology of the Economic pushes us to think about this crucial link. Monika Dommann, Daniel Speich Chassé and Mischa Suter explore different modes of approaching the interlacing of epistemology and economy. These modes can be discussed under the following headings: 1) Pragmatics and Poetologies of Knowledge, 2) Economic Discourses and Epistemic Techniques, 3) Boundaries of Economy. On the basis of the richness of the historical material and the finely grained arguments that these papers bring forth, I will elaborate on the conceptualization of these linkages between epistemology and economy. My discussion culminates in the attempt to clarify an analytical distinction that is freely used in this special issue but that deserves further discussion: the distinction between the economic and the economy as an object of historical epistemology. My question is, does it matter if we write a historical epistemology of the economic or of the economy? What distinction do we wish to make by juxtaposing these two?
Atmospheric vs. anaerobic processing of metabolome samples for the metabolite profiling of a strict anaerobic bacterium, Clostridium acetobutylicum
Authors: Lee Sang‐Hyun , Kim Sooah , Kwon Min‐A , Jung Young Hoon , Shin Yong‐An , Kim Kyoung Heon
Published: June 2014

Well‐established metabolome sample preparation is a prerequisite for reliable metabolomic data. For metabolome sampling of a Gram‐positive strict anaerobe, Clostridium acetobutylicum, fast filtration and metabolite extraction with acetonitrile/methanol/water (2:2:1, v/v) at −20°C under anaerobic conditions has been commonly used. This anaerobic metabolite processing method is laborious and time‐consuming since it is conducted in an anaerobic chamber. Also, there have not been any systematic method evaluation and development of metabolome sample preparation for strict anaerobes and Gram‐positive bacteria. In this study, metabolome sampling and extraction methods were rigorously evaluated and optimized for C. acetobutylicum by using gas chromatography/time‐of‐flight mass spectrometry‐based metabolomics, in which a total of 116 metabolites were identified. When comparing the atmospheric (i.e., in air) and anaerobic (i.e., in an anaerobic chamber) processing of metabolome sample preparation, there was no significant difference in the quality and quantity of the metabolomic data. For metabolite extraction, pure methanol at −20°C was a better solvent than acetonitrile/methanol/water (2:2:1, v/v/v) at −20°C that is frequently used for C. acetobutylicum, and metabolite profiles were significantly different depending on extraction solvents. This is the first evaluation of metabolite sample preparation under aerobic processing conditions for an anaerobe. This method could be applied conveniently, efficiently, and reliably to metabolome analysis for strict anaerobes in air. Biotechnol. Bioeng. 2014;111: 2528–2536. © 2014 Wiley Periodicals, Inc.
The effect of metformin on breast cancer outcomes in patients with type 2 diabetes
Authors: Oppong Bridget A. , Pharmer Lindsay A. , Oskar Sabine , Eaton Anne , Stempel Michelle , Patil Sujata , King Tari A.
Published: June 2014

Observational data suggest that metformin use decreases breast cancer (BC) incidence in women with diabetes; the impact of metformin on BC outcomes in this population is less clear. The purpose of this analysis was to explore whether metformin use influences BC outcomes in women with type 2 diabetes. Prospective institutional databases were reviewed to identify patients with diabetes who received chemotherapy for stages I–III BC from 2000 to 2005. Patients diagnosed with diabetes before or within 6 months of BC diagnosis were included. Males and those with type I, gestational, or steroid‐induced diabetes were excluded. Patients were stratified based on metformin use, at baseline, defined as use at time of BC diagnosis or at diabetes diagnosis if within 6 months of BC diagnosis. Kaplan–Meier methods were used to estimate rates of recurrence‐free survival (RFS), overall survival (OS), and contralateral breast cancer (CBC). We identified 313 patients with diabetes who received chemotherapy for BC, 141 (45%) fulfilled inclusion criteria and 76 (54%) used metformin at baseline. There were no differences in clinical presentation or tumor characteristics between metformin users and nonusers. At a median follow‐up of 87 months (range, 6.9–140.4 months), there was no difference in RFS (P = 0.61), OS (P = 0.462), or CBC (P = 0.156) based on metformin use. Five‐year RFS was 90.4% (95% CI, 84–97) in metformin users and 85.4% (95% CI, 78–94) in nonusers. In this cohort of patients with type 2 diabetes receiving systemic chemotherapy for invasive BC, the use of metformin was not associated with improved outcomes.
Effect of vitamin D3on behavioural and biochemical parameters in diabetes type 1‐induced rats
Authors: Calgaroto Nicéia Spanholi , Thomé Gustavo Roberto , da Costa Pauline , Baldissareli Jucimara , Hussein Fátima Abdala , Schmatz Roberta , Rubin Maribel A. , Signor Cristiane , Ribeiro Daniela Aymone , Carvalho Fabiano Barbosa , de Oliveira Lizielle Souza , Pereira Luciane Belmonte , Morsch Vera Maria , Schetinger Maria Rosa Chitolina
Published: June 2014

Diabetes is associated with long‐term complications in the brain and reduced cognitive ability. Vitamin D3(VD3) appears to be involved in the amelioration of hyperglycaemia in streptozotocin (STZ)‐induced diabetic rats. Our aim was to analyse the potential of VD3in avoiding brain damage through evaluation of acetylcholinesterase (AChE), Na+K+‐adenosine triphosphatase (ATPase) and delta aminolevulinate dehydratase (δ‐ALA‐D) activities and thiobarbituric acid reactive substance (TBARS) levels from cerebral cortex, as well as memory in STZ‐induced diabetic rats. Animals were divided into eight groups (n = 5): control/saline, control/metformin (Metf), control/VD3, control/Metf + VD3, diabetic/saline, diabetic/Metf, diabetic/VD3and diabetic/Metf + VD3. Thirty days after treatment, animals were submitted to contextual fear‐conditioning and open‐field behavioural tests, after which they were sacrificed and the cerebral cortex was dissected. Our results demonstrate a significant memory deficit, an increase in AChE activity and TBARS levels and a decrease inδ‐ALA‐D and Na+K+‐ATPase activities in diabetic rats when compared with the controls. Treatment of diabetic rats with Metf and VD3prevented the increase in AChE activity when compared with the diabetic/saline group. In treated diabetic rats, the decrease in Na+K+‐ATPase was reverted when compared with non‐treated rats, but the increase inδ‐ALA‐D activity was not. VD3prevented diabetes‐induced TBARS level and improved memory. Our results show that VD3can avoid cognitive deficit through prevention of changes in important enzymes such as Na+K+‐ATPase and AChE in cerebral cortex in type 1 diabetic rats. Copyright © 2014 John Wiley & Sons, Ltd.
Specific Maltose Derivatives Modulate the Swarming Motility of Nonswarming Mutant and Inhibit Bacterial Adhesion and Biofilm Formation by Pseudomonas aeruginosa
Authors: Shetye Gauri S. , Singh Nischal , Jia Changqing , Nguyen Chan D. K. , Wang Guirong , Luk Yan‐Yeung
Published: June 2014

We have demonstrated that specific synthetic maltose derivatives activate the swarming motility of a Pseudomonas aeruginosa nonswarming mutant (rhlA) at low concentration, but inhibit it at high concentration. Although these molecules are not microbicidal, active maltose derivatives with bulky hydrocarbon groups inhibited bacterial adhesion, and exhibited biofilm inhibition and dispersion (IC50 ∼20 μM and DC50 ∼30 μM, respectively). Because the swarming motility of the rhlA mutant is abolished by the lack natural rhamnolipids, the swarming activation suggests that maltose derivatives are analogues of rhamnolipids. Together, these results suggest a new approach of controlling multiple bacterial activities (bacterial adhesion, biofilm formation, and swarming motility) by a set of disaccharide‐based molecules.
Controlled Thermal Annealing Tunes the Photoelectrochemical Properties of Nanochanneled Tin‐Oxide Structures
Authors: Palacios‐Padrós Anna , Altomare Marco , Lee Kiyoung , Díez‐Pérez Ismael , Sanz Fausto , Schmuki Patrik
Published: June 2014

We study the effect of thermal annealing conditions (up to 400 °C) and atmospheres (air, Arand O2) on a newly developed nanochannel tin‐oxide structure. The nanochanneled structures were prepared by self‐organized anodization of metallic tin. Thermal annealing conditions have a strong impact on the crystallinity and content of Sn2+ defects present in the structure, and thus have a strong influence on the photoresponse characteristics of the films. Photocurrent measurements show that films annealed at 200 °C in Ar atmosphere exhibit a band gap as low as 2.4 eV and a photoresponse in the visible range. This effect is ascribed to a large content of Sn2+ defects in the structure and the improved crystallinity of the films annealed at this temperature. On the contrary, the Sn2+ content is decreased when annealing at 400 °C under aerobic conditions, which correlates with a shift in the film band gap to 3.2 eV, closer to the reported value for pure SnO2 (3.6 eV).
Pulse‐Plating of Mn–Cu–ZnO for Supercapacitors: A Study Based on Soft X‐ray Fluorescence and Absorption Microspectroscopy
Authors: Bozzini Benedetto , Gianoncelli Alessandra , Mele Claudio , Abyaneh Majid Kazemian , Jezersěk David , Sgura Ivonne , Kiskinova Maya
Published: June 2014

This paper reports on the electrodeposition of Mn–Cu–ZnO for hybrid supercapacitors. This material exhibits a dual structure consisting of Mn‐rich highly active, but poorly electronically conducting, grains, which are locked by a Cu‐rich highly conductive network that also possesses some degree of charge‐storage capacity. This work focuses on morphological, compositional, and chemical‐state distributions with submicrometer lateral resolution. This information, which is crucial because doping distribution controls supercapacitor performance, has been obtained by combining electrochemical and in situ Raman measurements with synchrotron‐based X‐ray fluorescence and absorption microspectroscopy. Using a microfabricated thin‐layer three‐electrode microcell, we followed the morphochemical changes at different electrodeposition stages and found that pulse‐plating allows the growth of Mn‐ and Cu‐doped ZnO as self‐organized structures with a consistent spatially stable composition distribution.
Systematic Control of the Excited‐State Dynamics and Carrier‐Transport Properties of Functionalized Benzo[ghi]perylene and Coronene Derivatives
Authors: Hirayama Sunao , Sakai Hayato , Araki Yasuyuki , Tanaka Minako , Imakawa Masaki , Wada Takehiko , Takenobu Taishi , Hasobe Taku
Published: June 2014

A series of benzo[ghi]perylene (Bp) and coronene (Cor) derivatives substituted with electron‐withdrawing methoxycarbonyl (COOMe) or electron‐donating methoxyl (MeO) groups was synthesized. The electrochemical, spectroscopic, and photophysical properties of these compounds were investigated by cyclic voltammetry, steady‐state and time‐resolved spectroscopy, and quantum‐yield measurements. Introduction of suitable substituents onto the aromatic rings enabled control of electrochemical and spectroscopic behavior. Examination of excited‐state dynamics revealed that fluorescence quantum yields increased with increasing number of COOMe groups in both Bp and Cor derivatives, consistent with the findings of DFT calculations. Single‐crystal analysis allowed the performance of field‐effect transistors containing single crystals of the derivatives to be rationalized.
ChemInform Abstract: Synthesis and Properties of Cobalt Sulfide Phases: CoS2 and Co9S8.
Authors: Kumar Nitesh , Raman Natarajan , Sundaresan Athinarayanan
Published: June 2014

Single phase CoS2 nanoparticles are prepared by thermal decomposition of the cobalt—(H2N)2C=S (tu) complex [Co(tu)4(NO3)2] at 400 °C.
ChemInform Abstract: Direct Growth of NiCo2S4 Nanotube Arrays on Nickel Foam as High‐Performance Binder‐Free Electrodes for Supercapacitors.
Authors: Pu Jun , Wang Tingting , Wang Haiyang , Tong Yao , Lu Chenchen , Kong Wei , Wang Zhenghua
Published: June 2014

NiCo2S4 nanotube arrays are grown by a two‐step hydrothermal process involving the loading of HCl cleaned Ni foam with precursors CoCl2 and NiCl2 (autoclave, 100 °C, 8 h) followed by adding the precursor foam to an aqueous Na2S solution (autoclave, 120 °C, 4 h).
ChemInform Abstract: Synthesis and Magnetic Properties of β‐KVOF3.
Authors: Donakowski Martin D. , Lu Hongcheng , Gautier Romain , Saha Rana , Sundaresan A. , Poeppelmeier Kenneth R.
Published: June 2014

β‐KVOF3 is prepared by in‐situ reduction under hydrothermal conditions using a mixture of V2O5 and KBr (3:2) in aq.
ChemInform Abstract: New Routes to Synthesizing an Ordered Perovskite CaCu3Fe2Sb2O12 and Its Magnetic Structure by Neutron Powder Diffraction.
Authors: Larregola Sebastian A. , Zhou Jianshi , Alonso Jose A. , Pomjakushin Vladimir , Goodenough John B.
Published: June 2014

A high‐quality A,B‐site‐ordered double perovskite CaCu3Fe2Sb2O12 is prepared at ambient pressure by two routes, a wet‐chemical procedure involving a mixture of CuO, Fe(NO3)3.9H2O, Ca(NO3)2, and Sb2O3 in citric acid and few HNO3 which is slowly evaporated and decomposed at 550 °C followed by a complex heating schedule (≈92% yield) and, secondly, by activating an oxide mixture of CuO, Fe2O3, Sb2O3, and CaCO3 by ball milling also followed by a complex heating schedule in which the amorphous material recrystallizes at < 820 °C (perovskite phase yield of 97%).
ChemInform Abstract: Ruthenium(V) Oxides from Low‐Temperature Hydrothermal Synthesis.
Authors: Hiley Craig I. , Lees Martin R. , Fisher Janet M. , Thompsett David , Agrestini Stefano , Smith Ronald I. , Walton Richard I.
Published: June 2014

Ca1.5Ru2O7 (I), SrRu2O6 (II), and Ba2Ru3O9(OH) (III) are hydrothermally synthesized from aqueous mixtures of KRuO4 and MO2 (M: Ca, Sr, Ba; autoclave, 200 °C, 24 h).
ChemInform Abstract: Enantioselective Organocatalytic Oxa‐Michael Addition of Oximes to β‐CF3‐β‐Disubstituted Nitroalkenes: Efficient Synthesis of β‐Amino‐α‐trifluoromethyl Alcohols.
Authors: Liu Feng‐Lei , Chen Jia‐Rong , Feng Bin , Hu Xiao‐Qiang , Ye Li‐Hua , Lu Liang‐Qiu , Xiao Wen‐Jing
Published: June 2014

The first organocatalyzed, asymmetric oxa‐Michael addition of oximes to β‐CF3‐β‐substituted nitroalkenes (I) furnishing CF3‐containing oxime ethers (III) (13 examples) in high yields and enantioselectivities is described.
ChemInform Abstract: Selective Synthesis of Indazoles and Indoles via Triazene—Alkyne Cyclization Switched by Different Metals.
Authors: Fang Yan , Wang Chengming , Su Shengqin , Yu Haizhu , Huang Yong
Published: June 2014

The copper‐mediated oxidative cyclization of alkynyl triazenes (I) leads to indazoles of type (II), whereas, the silver‐mediated reaction affords indoles of type (IV).
ChemInform Abstract: Effect of the Trifluoromethyl Group on Torquoselectivity in the 4π Ring‐Opening Reaction of Oxetenes: Stereoselective Synthesis of Tetrasubstituted Olefins.
Authors: Aikawa Kohsuke , Shimizu Natsumi , Honda Kazuya , Hioki Yuta , Mikami Koichi
Published: June 2014

The highly stereoselective synthesis of tetrasubstituted olefins such as (II)/(III), (V), (VII)/(VIII), and (X)/(XI) bearing a CF3‐group via the thermal 4π electrocyclic ring opening reaction of various oxetenes is described.
ChemInform Abstract: Catalytic Enantioselective Allylboration of Propargylic Aldehydes.
Authors: Bhakta Urmibhusan , Sullivan Erin , Hall Dennis G.
Published: June 2014

The utility of the products is demonstrated by Au/Ag‐catalyzed cycloisomerization of products (IVa,e) to bicyclic compounds (V).
ChemInform Abstract: Head‐to‐Tail Homo‐ and Heterodimerization of Vinylamides by Hidden Proton Catalysis.
Authors: Iqbal Naseem , Blakstad Guro , Fiksdahl Anne
Published: June 2014

N‐Vinylimidazole and N‐vinylphthalimide do not react under the present conditions (not shown).
ChemInform Abstract: TBAF Promoted Formation of Symmetrical Trisulfides.
Authors: Lach Slawomir , Witt Dariusz
Published: June 2014

The presented approach provides various advantages as easily accessible starting material, convenient manipulation, short reaction times, and very high purities and yields.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Coupling of Aryltrimethylammonium Triflates and Amines.
Authors: Zhang Xue‐Qi , Wang Zhong‐Xia
Published: June 2014

A practical one‐pot procedure starting from dimethylarylamines instead of compounds (I) is also presented.
ChemInform Abstract: NBS Mediated Nitriles Synthesis Through C=C Double Bond Cleavage.
Authors: Zong Xiaolin , Zheng Qing‐Zhong , Jiao Ning
Published: June 2014

Benzonitriles are prepared from electron‐rich styrenes in the presence of NBS, Tms‐N3, and copper(II) acetate in moderate yields.
ChemInform Abstract: Broensted Acid‐Assisted N‐Alkylation of Sulfonamides Using Ethers as the Alkylation Reagents.
Authors: Shi Wei , Bai Chun‐Mei , Zhu Kai , Cui Dong‐Mei , Zhang Chen
Published: June 2014

The reaction of cyclic ethers affords pyrrolidine and piperidine derivatives, whereas the reaction of symmetrical and unsymmetrical ethers give the corresponding mono N‐alkylated products.
ChemInform Abstract: Simple Conversion of Thiols to Disulfides in EtOH under Ambient Aerobic Conditions Without Using Any Catalyst or Additive.
Authors: Wang Hang , Huang Guojun , Sun Yang , Liu Yunyun
Published: June 2014

The reaction can be readily scaled up.
ChemInform Abstract: 4‐Dimethylaminopyridine‐Catalyzed Multi‐Component One‐Pot Reactions for the Convenient Synthesis of Spiro[indoline‐3,4′‐pyrano[2,3‐c]pyrazole] Derivatives.
Authors: Feng Jun , Ablajan Keyume , Sali Ahat
Published: June 2014

The title compounds can be prepared by a three‐ or four‐step one‐pot reaction, whereas the latter one gives better yields.
ChemInform Abstract: Practical and Efficient Synthesis of Chiral 2,4‐Disubstituted Oxazolines from β‐Phosphonoamides.
Authors: Avalos‐Alanis Francisco G. , Hernandez‐Fernandez Eugenio , Hernandez‐Romero Rocio , Lopez‐Cortina Susana , Ordonez Mario , Garcia‐Barradas Oscar , Lagunas‐Rivera Selene
Published: June 2014

Different routes for the preparation of the title compounds are described.
ChemInform Abstract: Regioselective One‐Pot C—N Coupling of Substituted Naphthoquinones: Selective Intramolecular Ring Fusion of Sulfonamides.
Authors: Yu Wenying , Li Chenglong
Published: June 2014

The title novel reaction provides a selective method to synthesize both ring‐fused (III) and ring‐opened (IV) products.
ChemInform Abstract: Studies on the Oxidative Cyclization of 3‐Hydroxyalkyl‐1,2,4‐trialkoxynaphthalenes and Synthetic Application for the Biologically Active Natural Compound Rhinacanthone (XI).
Authors: Ogata Tokutaro , Doe Misae , Matsubara Aya , Torii Eri , Nishiura Chiaki , Nishiuchi Arisa , Kobayashi Yusuke , Kimachi Tetsutaro
Published: June 2014

The proposed mechanism suggests that the reaction proceeds by a stepwise oxidation‐cyclization sequence.
ChemInform Abstract: SiO2—OSO3H Nanoparticles: An Efficient, Versatile and New Reagent for the One‐Pot Synthesis of 2‐Amino‐8‐oxo‐4,8‐dihydropyrano[3,2‐b]pyran‐3‐carbonitrile Derivatives in Water, a Green Protocol.
Authors: Sadeghi Bahareh , Nezhad Parinaz Farokhi , Hashemian Saeedeh
Published: June 2014

The solid phase acidic catalyst is reusable several times without significant loss of activity.
ChemInform Abstract: Synthesis of Polyhydroxylated Indolizidines and Piperidines from Garner′s Aldehyde: Total Synthesis of (‐)‐Swainsonine, (+)‐1,2‐Di‐epi‐swainsonine, (+)‐8,8a‐Di‐epi‐castanospermine, Pentahydroxy Indolizidines, (‐)‐1‐Deoxynojirimycin, (‐)‐1‐Deoxy‐altro‐nojirimycin, and Related Diversity.
Authors: Singh Priyanka , Manna Sudipta Kumar , Panda Gautam
Published: June 2014

Diastereoselective and diverse syntheses of polyhydroxylated indolizidines and piperidines are described, where the common chiral intermediate 2‐(hydroxymethyl) piperidine‐3‐ol is converted into 1‐deoxy‐altro‐nojirimycin derivatives (I), 1‐deoxynojirimycin (II), 1,2‐di‐epi‐swainsonine (III), swainsonine (IV), 8,8a‐di‐epi‐castanospermine (V), and isomeric pentahydroxy indolizidines (VI) and (VII).
ChemInform Abstract: Catalytic Regioselective Synthesis of Pyrazole Based Pyrido[2,3‐d]pyrimidine‐diones and Their Biological Evaluation.
Authors: Satasia Shailesh P. , Kalaria Piyush N. , Raval Dipak K.
Published: June 2014

The synthesized pyrazole based pyrido pyrimidine‐diones are evaluated for their in vitro antimicrobial, antituberculosis and antimalarial activities.
ChemInform Abstract: Unexpected Heteroannulation and Chlorination of Benzothiadiazine Derivatives Mediated by DDQ.
Authors: Verones Valerie , Flouquet Nathalie , Farce Amaury , Berthelot Pascal , Lebegue Nicolas
Published: June 2014

Attempted DDQ oxidation of benzothiadiazine derivatives (III) at the dihydroimidazo or tetrahydropyrimidino ring moiety results in unexpected cyclization to give chlorinated tetracyclic products (IV) in low yields.
ChemInform Abstract: Chemoenzymatic Synthesis and HPLC Analysis of the Stereoisomers of Miyakosyne A [(4E,24E)‐14‐Methyloctacosa‐4,24‐diene‐1,27‐diyne‐3,26‐diol], a Cytotoxic Metabolite of a Marine Sponge Petrosia sp., to Determine the Absolute Configuration of Its Major Component as 3R,14R,26R.
Authors: Mori Kenji , Akasaka Kazuaki , Matsunaga Shigeki
Published: June 2014

Six stereoisomers of the natural miyakosyne A (I) are synthesized from the corresponding enantiomers of citronellal.
ChemInform Abstract: Didemnaketals D and E, Bioactive Terpenoids from a Red Sea ascidian Didemnum Species.
Authors: Mohamed Gamal A. , Ibrahim Sabrin R.M. , Badr Jihan M. , Youssef Diaa T. A.
Published: June 2014

The title compounds show moderate antimicrobial and protein kinase inhibitory activities.
ChemInform Abstract: Chemical Synthesis of Staphyloferrin A (I) and Its Application for Staphylococcus aureus Detection.
Authors: Pandey Rajesh K. , Jarvis Gregory G. , Low Philip S.
Published: June 2014

The title compound synthesized in six steps with 79% overall yield, shows excellent capacity to bind S.
ChemInform Abstract: Thermodynamic Assessment of the Al—P System Based on Original Experimental Data
Authors: Liang Song‐Mao , Schmid‐Fetzer Rainer
Published: June 2014

Review: 54 refs.
ChemInform Abstract: Fused‐ring Metallabenzenes
Authors: Frogley Benjamin J. , Wright L. James
Published: June 2014

Review: syntheses, spectroscopic properties, structures and reactions of fused‐ring meallabenzenes; 38 refs.
ChemInform Abstract: Supramolecular Assemblies of Multi‐nuclear Transition Metal Complexes: Synthesis and Redox Properties
Authors: Tanaka Shinji , Tsurugi Hayato , Mashima Kazushi
Published: June 2014

Review: 169 refs.
ChemInform Abstract: Coordination‐Induced Skeletal Rearrangements of Zirconacyclobutene‐Silacyclobutene Fused Complexes
Authors: Zhao Jing , Zhang Shaoguang , Zhang Wen‐Xiong , Xi Zhenfeng
Published: June 2014

Review: 198 refs.
ChemInform Abstract: Extraordinary Aggregation of Inorganic Anions in Chiral Metallosupramolecular Ionic Crystals
Authors: Lee Raeeun , Igashira‐Kamiyama Asako , Okumura Mitsutaka , Konno Takumi
Published: June 2014

Review: [review with new data; 31 refs.
ChemInform Abstract: Chemoselective Reductions and Iodinations Using Titanium Tetraiodide
Authors: Hachiya Iwao , Shimizu Makoto
Published: June 2014

Review: [48 refs.
ChemInform Abstract: Intramolecular Diels—Alder Cycloaddition of Furans (IMDAF) for Natural Product Synthesis
Authors: Padwa Albert , Flick Andrew C.
Published: June 2014

Review: 101 refs.
ChemInform Abstract: Reactions Triggered by Lewis Acidic Organoaluminum Species
Authors: Naganawa Yuki , Maruoka Keiji
Published: June 2014

Review: 83 refs.
ChemInform Abstract: Enantioselective Imine Reduction Catalyzed by Imine Reductases and Artificial Metalloenzymes
Authors: Gamenara Daniela , Dominguez de Maria Pablo
Published: June 2014

Review: [25 refs.
ChemInform Abstract: Nucleophilic Addition to N‐Alkoxyamides
Authors: Sato Takaaki , Chida Noritaka
Published: June 2014

Review: 9 refs.
ChemInform Abstract: N,N′‐Bis[3,5‐bis(trifluoromethyl)phenyl]thiourea: A Privileged Motif for Catalyst Development
Authors: Zhang Zhiguo , Bao Zongbi , Xing Huabin
Published: June 2014

Review: 64 refs.