bluuebunny/crossref_metadata_2025 huggingface dataset:
3D-QSAR Studies on High-affinity Phosphodiestera
Authors: Shi Luyang , Si Hongzong
Published: January 2024

Background:

Recent studies have found that Phosphodiesterase-4 (PDE4) is
closely related to the pathogenesis of depression, cognitive impairment and neurological
impairment.

Objective:

Our objective is to develop potent inhibitors of the high-affinity phosphodiesterase
4D isoform (PDE4D) that can serve as radioligands for Positron Emission Tomography
(PET) imaging, thereby advancing research in the field of neurological diseases.

Methods:

We employed a multi-step approach combining three-dimensional quantitative
structure-activity relationship (3D-QSAR) modeling, molecular docking, classification
techniques, and CoMSIA analysis to investigate the conformational relationship of highaffinity
PDE4D inhibitors as PET ligands. ADMET and Drug-likeness predictions were
also conducted. By utilizing these methods, our aim was to identify more potent PDE4D
inhibitors.

Results:

The results showed that the CoMSIA model with the best principal component
scores (n=7) had a cross-validated Q2 value of 0.602 and a non-cross-validated R2 value
of 0.976. These results affirmed the excellent predictive capability of the established
CoMSIA model. Analysis of the generated 3D-QSAR contour plots highlighted specific
regions in the molecular structure of the compounds that can be further optimized and
modified. Guided by the contour plots, we designed 100 novel PDE4D inhibitors, and molecular
docking was performed for the top 4 compounds with high activity. The molecular
docking scores were promising, and ADMET and drug similarity predictions yielded satisfactory
results. Taking into consideration these factors, compound 51c was determined
to be the optimal compound, laying a solid foundation for further research.

Conclusion:

For the continued development of PDE4D PET radioligand, these models
and new compounds' developing methodology offer a theoretical foundation and crucial
references.
Synthesis and Antitumor Activity of Some New N1-(8-fluoro-4-oxoquinolin-5-yl)amidrazones
Authors: Yahya Hind M. A. , Zahra Jalal A. , Sabri Salim S. , El-Abadelah Mustafa M. , Bardaweel Sanaa
Published: January 2024

Background:

Hydrazonoyl chloride, accessible from the respective 5-amino-8-fluoro-4-oxoquinoline-3-carboxylate, undergoes a reaction with sec-cyclic amines to generate N1-(1-ethyl-8-fluoro-4-oxoquinolin-5-yl)amidrazone carboxylates.

Introduction:

A novel set of N1-(1-ethyl-8-fluoro-4-oxoquinolin-5-yl)amidrazone carboxylates (7a-h) incorporating N-piperazines or related congeners was synthesized via interaction of the hy-drazonoyl chloride (6), accessible from the respective 5-amino-8-fluoro-4-oxoquinoline-3-carbox-ylate, with the appropriate sec-cyclic amine. These new compounds were characterized by 1H-NMR, 13C-NMR, and HRMS spectral data and screened for their anticancer activities.

Aims:

This study aimed at the synthesis of novel N1-( 4-oxoquinolin-5-yl)amidrazone carboxylate derivatives and investigated their potential as anticancer agents.

Objective:

The reaction of hydrazonoyl chloride with the appropriate sec-cyclic amine was applied to synthesize a novel set of N1-(1-ethyl-8-fluoro-4-oxoquinolin-5- yl)amidrazone carboxylates that incorporate N piperazines.

Methods:

A direct reaction of piperazines and related sec-cyclic amines with N-(4-oxoquinolin-5-yl)nitrile imine (1,3-dipole) was carried out for 8-10 h.

Results:

The 1,3-dipole, generated in situ from its hydrazonoyl chloride precursor in the presence of trimethylamine, is suitable for the facile synthesis of N1-(1-ethyl-8-fluoro-4-oxoquinolin-5-yl)amidrazone carboxylates.

Conclusion:

This study led to the successful synthesis of novel N1-(8-fluoro-4-oxoquinolin-5-yl)amidrazones. All the examined compounds showed moderate activity with reasonable IC50 values in the micromolar range compared to Doxorubicin.
Arthroscopic Excision of a Localized Tenosynovial Giant Cell Tumor of
the Knee: A Case Report
Authors: Zmerly Hassan , Draghetti Maurizio , Moscato Manuela , Akkawi Ibrahim
Published: January 2024

Background and Aim:

A tenosynovial giant cell tumor (TGCT) is a proliferative lesion
of the synovial membrane of the joints, tendon sheaths and/or bursae. There are two described subtypes,
including the localized and diffuse forms. A TGCT can also be intraarticular or extraarticular.
An intraarticular localized tenosynovial giant cell tumor (L-TGCT) of the knee is characterized
by nodular hyperplasic synovial tissue that can remain asymptomatic for a long time, but as
the mass grows, it may cause mechanical symptoms that may require surgical treatment. The aim
of our study is to present a rare case of an L-TGCT of the knee joint treated with an arthroscopic
excision.

Case Report:

We describe the case of a 17-year-old female with pain, swelling and knee locking
in the absence of trauma. The magnetic resonance imaging (MRI) displayed a well-circumscribed
small mass in the anterior medial compartment, adherent to the infrapatellar fat pad. The lesion
presented the typical MRI characteristics of an intraarticular localized TGCT. The patient was
treated with an arthroscopic mass removal and partial synovectomy. The gross pathology showed
an ovoid nodule that was covered by a fibrous capsule; a histopathology examination confirmed
the diagnosis. The patient was able to return to normal daily activities one month after surgery; at
the three-year follow-up, she was free of symptoms with no evidence of disease on the MRI.

Conclusion:

In patients with a small-dimension L-TGCT in the anterior compartment of the knee
that presents an MRI pattern and causes mechanical symptoms, an arthroscopic en-bloc excision
can be performed that results in good outcomes and a rapid return to preinjury levels.
Subchronic Toxicity Assessment of Zingiber roseum Rhizome in Mice
Model: Safety Evaluation at Various Doses
Authors: Amanat Muhammed , Daula A.F.M. Shahid Ud , Singh Randhir
Published: January 2024

Aims:

The aim of this study is to determine the potential adverse effects associated
with the prolonged administration of Zingiber roseum rhizome extract.

Background:

This study aimed to evaluate the sub-chronic toxicity of Z. roseum, commonly
known as rosy ginger, using a mouse model. Z. roseum has been traditionally used for its medicinal
properties; however, there is limited information regarding its potential toxic effects.

Objective:

The objective of this study is to assess the safety profile of ZRR extract at various doses
and conduct a detailed analysis of hematological, biochemical, and histological parameters regarding
sub-chronic toxicity.

Methods:

Mice were orally administered ZRR methanolic extract at doses of 300, 600, and 1200
mg/kg for 14 days as per the guidelines of ‘The Brazilian Agency of National Health Surveillance.’
Subchronic toxicity was conducted by monitoring multiple indicators, including changes in
body weight, food and water consumption, blood profile (HB, RBC, WBC, and PLT), and biochemical
markers (ALT, AST, ALP, TP, ALB, TC, TG, HDL, LDL, Creatinine, and Urea) and histopathological
examination of the liver.

Results:

Throughout the study, the mice showed normal behavior and appeared healthy. The administration
of Z. roseum at all tested doses did not significantly affect body weight, food, and water
intake, blood, biochemical markers, or liver. Z. roseum at these doses was safe, with no fatalities
or harm.

Conclusion:

Lastly, the sub-chronic administration of Z. roseum at doses of 300, 600, and 1200
mg/kg in a mice model did not elicit any toxic effects, indicating its potential safety as a therapeutic
agent.
Antioxidant Activity and Antitumor Potential of Hedyotis chrysotricha
Extract in Human Colorectal Cancer and Breast Cancer Cell Lines
Authors: Zhang Jing , Li Shannuo , Lv Qianqian , Lin Jiahui , Xiao Ying , Liang Jiajie , Zhang Tianwan , Zeng Lili , Guo Peiting , Ji Hong
Published: January 2024

Background:

Cancer is a serious disease severely endangering human health and life in
the world in the world, and conventional anticancer drugs have frequently suffered from severe side
effects and resistance. Therefore, developing novel and effective therapeutic strategies is urgently
needed. As a Chinese herbal medicine with important medical values, Hedyotis chrysotricha has
been suggested to be useful for the treatment of many diseases, especially cancer.

Objective:

Our aim was to investigate the antioxidant and antitumor activities of the phytochemical
extracts of H. chrysotricha.

Methods:

2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay was applied to determine
antioxidant property. 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide assay, wound
healing assay, transwell matrix assay, flow cytometry and cell morphology were established to observe
anti-proliferative, anti-migration, anti-invasion and apoptosis induction effects. The intracellular
reactive oxygen species generation was detected by reactive oxygen species detection assay.

Results:

The ethyl acetate fraction showed promising antioxidant activity with IC50 of 98.67±0.49
μg/ml, and petroleum ether fraction exhibited the most potent antiproliferative effect on various human
cancer cell lines, especially MDA-MB-231 (IC50 = 8.90±1.23 μg/ml) and HCT-116 (IC50 =
9.69±3.69 μg/ml) cancer cells. Further investigation revealed that the petroleum ether fraction suppressed
the proliferation, migration and invasion of the cancer cells significantly. Additionally, it
promoted cell apoptosis by increasing reactive oxygen species levels.

Conclusion:

H. chrysotricha extract possessed excellent antioxidant and antitumor activities. Therefore,
it could be useful as a source of antioxidants and compounds for cancer therapy.
Pemodelan Hidrologi DAS Gandong dengan Soil and Water Assessment Tool (ArcSWAT)
Authors: Ade Liya Intan Sari  , Donny Harisuseno  , Ussy Andawayanti
Published: January 2024

Lahan merupakan salah satu kebutuhan penting manusia untuk menunjang aktivitas manusia setiap hari. Peningkatan pertumbuhan penduduk yang terjadi secara langsung dapat mempengaruhi perubahan penggunaan lahan dan perubahan luasnya. Adanya perubahan penggunaan lahan dapat menyebabkan perubahan dan ketidangseimbangan proses hidrologi yang terjadi di suatu daerah. Pemodelan hidrologi adalah alat yang efektif untuk pengelolaan sumber daya lahan dan air serta mempelajari perilaku hidrologi DAS. Soil and Water Assessment Tool (SWAT) merupakan suatu model yang bekerja secara harian yang dapat dikombinasikan dengan Sistem Informasi Geografis (SIG) (ArcGIS) untuk memprediksi limpasan permukaan, debit sungai, sedimen dan kimia dari lahan dengan berbagai skenario manajemen lahan. Hasil simulasi dari model menunjukkan di DAS Gandong tahun 2021 menghasilkan air (water yield) sebesar 58.7% dari total curah hujan, dengan 41.27% nya berubah menjadi limpasan permukaan, 28.9% menjadi aliran dasar dan 27.9% menjadi aliran lateral. Evapotranspirasi yang terjadi dari simulasi model SWAT yakni 38.25% dari hujan yang jatuh di DAS Gandong. Model SWAT dapat diterapkan di DAS Gandong, berdasarkan uji statistik yang dilakukan untuk mengevaluasi kinerja model menggunakan NSE, koefisien determinasi, dan PBIAS termasuk dalam Satisfactory yang artinya simulasi model yang dilakukan cukup akurat dan konsisten.
Het recht op de Afrikaanse stad
Authors: Kagia Hezron
Published: January 2024

Steden worden beschouwd als de bouwstenen van nationale economieën en centra van innovatie. Toch zijn ze door hun diversiteit in bevolking en in gebruik ook een bron van marginalisering en uitsluiting geworden. Dit artikel onderzoekt hoe gemarginaliseerde sloppenwijkbewoners in Nairobi, Kenia, hun collectieve macht hebben gebruikt om het recht op te eisen op een stad die hen (nog steeds) uitsluit.
Digitale herbebossing
Authors: Ieremia Villi
Published: January 2024

Stel je voor dat je dagelijkse surfgedrag de planeet groener kan maken en elke klik van je online zoektocht een boom oplevert. Dit is geen science-fictionscenario: zoekmachine Ecosia plant al dan 10 jaar bomen om de wereldwijde achteruitgang van de natuur tegen te gaan. Maar er zit een addertje onder het gras.
Relationship between sexist ambivalence and jealousy in university students' relationships
Authors: Turriate-Chávez Jairo , Miñán-Olivos Guillermo
Published: January 2024

In Peru, the issue of intimate partner violence, which includes physical, sexual, or psychological harm by a current or former partner, is significant. Statistics show that a high percentage of women experience psychological, physical, and sexual violence. The Ministry of Women and Vulnerable Populations highlights that this violence affects women's mental health, self-worth, and puts them at risk of femicide. This study explores the link between sexist attitudes and jealousy in university students' relationships as potential indicators of violence. It involved 138 undergraduates, selected randomly, and used quantitative methods, including surveys on sexism and jealousy. The findings reveal a statistically significant but low positive correlation between sexist attitudes and jealousy in these relationships.
Virtual and Interprofessional Objective Structured Clinical Examination in Dentistry and Dental Technology: Development and User Evaluations
Authors: Pang MengWei , Dong YanLing , Zhao XiaoHan , Wan JiaWu , Jiang Li , Song JinLin , Ji Ping , Jiang Lin
Published: January 2024

Background

Interprofessional education (IPE) facilitates interprofessional collaborative practice (IPCP) to encourage teamwork among dental care professionals and is increasingly becoming a part of training programs for dental and dental technology students. However, the focus of previous IPE and IPCP studies has largely been on subjective student and instructor perceptions without including objective assessments of collaborative practice as an outcome measure.

Objective

The purposes of this study were to develop the framework for a novel virtual and interprofessional objective structured clinical examination (viOSCE) applicable to dental and dental technology students, to assess the effectiveness of the framework as a tool for measuring the outcomes of IPE, and to promote IPCP among dental and dental technology students.

Methods

The framework of the proposed novel viOSCE was developed using the modified Delphi method and then piloted. The lead researcher and a group of experts determined the content and scoring system. Subjective data were collected using the Readiness for Interprofessional Learning Scale and a self-made scale, and objective data were collected using examiner ratings. Data were analyzed using nonparametric tests.

Results

We successfully developed a viOSCE framework applicable to dental and dental technology students. Of 50 students, 32 (64%) participated in the pilot study and completed the questionnaires. On the basis of the Readiness for Interprofessional Learning Scale, the subjective evaluation indicated that teamwork skills were improved, and the only statistically significant difference in participant motivation between the 2 professional groups was in the mutual evaluation scale (P=.004). For the viOSCE evaluation scale, the difference between the professional groups in removable prosthodontics was statistically significant, and a trend for negative correlation between subjective and objective scores was noted, but it was not statistically significant.

Conclusions

The results confirm that viOSCE can be used as an objective evaluation tool to assess the outcomes of IPE and IPCP. This study also revealed an interesting relationship between mutual evaluation and IPCP results, further demonstrating that the IPE and IPCP results urgently need to be supplemented with objective evaluation tools. Therefore, the implementation of viOSCE as part of a large and more complete objective structured clinical examination to test the ability of students to meet undergraduate graduation requirements will be the focus of our future studies.
Assessing the Quality, Privacy, and Security of Breast Cancer Apps for Arabic Speakers: Systematic Search and Review of Smartphone Apps
Authors: Alhuwail Dari , Alhouti Aisha , Alsarhan Latifah
Published: January 2024

Background

Breast cancer is a widespread disease, and its incidence is rapidly increasing in the Middle East and North Africa region. With the increasing availability of smartphone apps for various health purposes, breast cancer apps have emerged as tools for raising awareness, providing support, and empowering women affected by this disease. These apps offer many features, including information on breast cancer risk factors, self-examination guides, appointment reminders, and community support groups or hotlines. Using apps raises the risk of privacy and security issues, and we hope that examining these features of the apps will contribute to the understanding of how technology can be used to improve these apps and provide insights for future development and improvement of breast cancer apps.

Objective

This study aims to critically review the quality, privacy, and security of breast cancer apps available to Arabic speakers.

Methods

Similar to several recent studies, we used a systematic search for apps available in Google Play and Apple App stores using both the web interface and the built-in native stores installed on smartphones. The search was conducted in mid-December 2022 in Arabic using the following keywords: سرطان الثدي – فحص سرطان الثدي – علاج سرطان الثدي – مرض سرطان الثدي – أعراض سرطان الثدي – فحص الثدي (breast cancer, breast cancer treatment, breast cancer disease, breast cancer symptoms, breast cancer screening, and breast test). These preidentified search terms are based on earlier work concerning the top searched breast cancer topics by Arabic speakers through Google’s search engine. We excluded apps that did not have an Arabic interface, were developed for non-Arabic speakers, were paid, needed a subscription, or were directed toward health care workers. The Mobile App Rating Scale was used to evaluate the quality of the apps concerning their engagement, functionality, aesthetics, and information. A risk score was calculated for the apps to determine their security risk factors.

Results

Only 9 apps were included, with most (6/9, 67%) being supported by advertisements and categorized as informational. Overall, the apps had low numbers of downloads (>10 to >1000). The majority of the included apps (8/9, 89%) requested dangerous access permissions, including access to storage, media files, and the camera. The average security score of the included apps was 3.22, while only 2 apps provided information about data security and privacy. The included apps achieved an overall average quality score of 3.27, with individual dimension scores of 4.75 for functionality, 3.04 for information, 3.00 for aesthetics, and 2.32 for engagement.

Conclusions

The limited availability of breast cancer apps available to Arabic speakers should be a call to action and prompt health care organizations and developers to join forces and collaboratively develop information-rich, usable, functional, engaging, and secure apps.
A Generative Pretrained Transformer (GPT)–Powered Chatbot as a Simulated Patient to Practice History Taking: Prospective, Mixed Methods Study
Authors: Holderried Friederike , Stegemann–Philipps Christian , Herschbach Lea , Moldt Julia-Astrid , Nevins Andrew , Griewatz Jan , Holderried Martin , Herrmann-Werner Anne , Festl-Wietek Teresa , Mahling Moritz
Published: January 2024

Background

Communication is a core competency of medical professionals and of utmost importance for patient safety. Although medical curricula emphasize communication training, traditional formats, such as real or simulated patient interactions, can present psychological stress and are limited in repetition. The recent emergence of large language models (LLMs), such as generative pretrained transformer (GPT), offers an opportunity to overcome these restrictions

Objective

The aim of this study was to explore the feasibility of a GPT-driven chatbot to practice history taking, one of the core competencies of communication.

Methods

We developed an interactive chatbot interface using GPT-3.5 and a specific prompt including a chatbot-optimized illness script and a behavioral component. Following a mixed methods approach, we invited medical students to voluntarily practice history taking. To determine whether GPT provides suitable answers as a simulated patient, the conversations were recorded and analyzed using quantitative and qualitative approaches. We analyzed the extent to which the questions and answers aligned with the provided script, as well as the medical plausibility of the answers. Finally, the students filled out the Chatbot Usability Questionnaire (CUQ).

Results

A total of 28 students practiced with our chatbot (mean age 23.4, SD 2.9 years). We recorded a total of 826 question-answer pairs (QAPs), with a median of 27.5 QAPs per conversation and 94.7% (n=782) pertaining to history taking. When questions were explicitly covered by the script (n=502, 60.3%), the GPT-provided answers were mostly based on explicit script information (n=471, 94.4%). For questions not covered by the script (n=195, 23.4%), the GPT answers used 56.4% (n=110) fictitious information. Regarding plausibility, 842 (97.9%) of 860 QAPs were rated as plausible. Of the 14 (2.1%) implausible answers, GPT provided answers rated as socially desirable, leaving role identity, ignoring script information, illogical reasoning, and calculation error. Despite these results, the CUQ revealed an overall positive user experience (77/100 points).

Conclusions

Our data showed that LLMs, such as GPT, can provide a simulated patient experience and yield a good user experience and a majority of plausible answers. Our analysis revealed that GPT-provided answers use either explicit script information or are based on available information, which can be understood as abductive reasoning. Although rare, the GPT-based chatbot provides implausible information in some instances, with the major tendency being socially desirable instead of medically plausible information.
La industria manufacturera en México: un análisis de su productividad y eficiencia, 1993-2020
Authors: Guzmán Soria Eugenio , De la Garza Carranza María Teresa , Atlatenco Ibarra Quetzalli , Terrones Cordero Aníbal
Published: January 2024

En este trabajo se estimó la productividad y eficiencia de la industria manufacturera en México, mediante una función de producción doble logarítmica no homogénea (NHPF) y datos anuales de 1993 a 2020. El dinero, como insumo en la función de producción, se consideró como argumento teórico. Durante el periodo analizado, las elasticidades de salida promedio del trabajo y del crédito bancario indican una productividad de 1.5 y 0.05, respectivamente, mientras que los retornos a escala promedio del sector manufacturero ubican su eficiencia en 1.55. La deficiencia crediticia sugiere la necesidad de mecanismos eficientes de asignación de financiamiento para el sector.
Cerebellar syndrome in heat stroke (literary review)
Authors: Kravets O.V. , Yekhalov V.V. , Sedinkin V.A. , Ploshchenko Yu.O.
Published: January 2024

The central nervous system is very sensitive to hyperthermia, which causes neurological complications through alteration of the cerebellum, basal ganglia, anterior horn cells, and peripheral nerves. Cerebellar damage is associated with generalized atrophy and signs of Purkinje cell involvement. Heat shock (stroke) is a critical condition caused by hyperthermia, typified by symmetrical damage to the cerebellum. The critical core temperature for the brain is 40–41 °C, but damage to the cerebellum can occur at lower temperatures. In the central nervous system, cerebellar Purkinje cells are most susceptible to hyperpyrexia-induced dysfunction. The degree of their loss correlates with the severity and duration of hyperthermia. Heat hyperpyrexia-induced cerebellar atrophy usually involves both the vermis and the cerebellar hemispheres. Heat stroke can also cause neurological dysfunction, most commonly due to cerebellar damage. During the acute stage, typical neurological disorders are cerebellar ataxia, cognitive impairment, dysphagia, and aphasia. The convalescent period is characterized by transient cerebellar dysfunction; diffuse cerebellar atrophy has been described, and cerebellar degeneration is a well-known consequence of heat stroke. In permanent cerebellar dysfunction after heat stroke, permanent neurological deficit is relatively rare, and the most common manifestation is cerebellar syndrome. The most common X-ray finding in heat stroke is diffuse cerebellar atrophy with preserved brain volume, which is caused by diffuse loss of Purkinje cells and, according to computed tomography and magnetic resonance imaging, mostly affects the vermis or the cerebellar hemispheres, with the hemispheres of the brain mostly remain intact. Cerebellar disorders caused by heat stroke is a complex neurological problem. To rule out an alternative diagnosis, a thorough special examination with neuroimaging is necessary.
About chronic cerebrovascular insufficiency caused by cardiac pathology (literature review)
Authors: Zozulya I.S. , Volosovets A.O.
Published: January 2024

The widespread introduction of cardiological diagnostic methods in clinical angioneurology has significantly enriched the data on the role of cardiovascular diseases in the development of cerebrovascular pathology. Various cardiac disorders play a significant role in the development of cardioembolic and haemodynamic ischaemic strokes. It has been scientifically proven that chronic heart failure, along with hypertension, is a risk factor for the occurrence of a chronic form of cerebrovascular disease — chronic cerebrovascular insufficiency. The characteristic feature of all types of cardiovascular insufficiency is the inability of the circulatory system to deliver to the organs, systems, tissues, including the brain, the amount of blood necessary for their normal functioning, both at rest and especially during exertion. In their daily practice, neurologists encounter patients with chronic heart failure and symptoms of cerebrovascular disease (memory loss, reduced performance, depression). Underestimation of these conditions can result in a shortened life due to irreversible damage to target organs (heart, brain, kidneys). In the absence of adequate treatment, death is possible within the first 5 years after the onset of heart failure. The degree of disease progression depends on many factors: clinical and pathogenetic variant of chronic heart failure, the rate of the pathological process, the presence of myocardial damage and remodeling, complications from target organs. In this article, we tried to analyse the literature data of domestic and foreign authors on the pathogenetic mechanisms of chronic heart failure, the impact on its development and the course of its complications, and, above all, brain damage in the form of chronic cerebrovascular insufficiency.
Governance for Sustainable Development for Nickel Project in Indonesia
Authors: Hairi Muhammad Imam Akbar , Zukriadi Diki , Wulung Lingga Angling , Husda Nur Elfi
Published: January 2024

The paper investigates the governance and administrative process in the nickel project in Indonesia and offers suggestions to apply governance for sustainable development concept for creating an eco-mobility industry in Indonesia. This paper is a case study using qualitative methodology and governance for sustainable development theoretical framework. In applying qualitative methodology, this paper is supported by previous research publications, local press publications, and interviews. The governance for sustainable development is used as a strategic guideline in mining project to develop Indonesia’s eco-mobility industry further. This paper has three findings. First, the nickel project in Indonesia is part of bilateral cooperation between Indonesia with the National Strategic Program and China with the Belt and Road Initiative program. Thus, the concept of governance is not only applied in domestic policy but also bilateral cooperation. Second, non-technical issues have been identified during the governance and administrative process of nickel project in Indonesia. The governance concept must be applied to resolve the project’s non-technical problems and make it sustainable. Third, all the governance stakeholders in the nickel project must adopt a sustainable governance development framework. Indonesia should avoid further setback and refrain from the previous oil-booming phenomenon in the 1970s. The governance sustainable development concept requires all the stakeholders in the mining project to cooperate inclusively. It comprises extraction, production, recycling-waste management, e-vehicle industry, social acceptance, and rehabilitating the environment (land, air, water, and the living beings) affected by mining activities. This paper highlights Indonesia’s experience in creating an eco-mobility industry, using the nickel project as the key driver under investigation.
Application of Five-tone Therapy Combined with Acupressure in Colonoscopy
Authors: Yi Ran
Published: January 2024

Colonoscopy is an important method for the diagnosis of digestive tract diseases, especially in the diagnosis and treatment of colorectal cancer has a key role. But as an invasive medical procedure, colonoscopy can lead to more severe pain in patients, and even cause intestinal inflation, resulting in patients with abdominal distension, intestinal spasms and other discomfort. Therefore, relieving the pain of patients during colonoscopy has become an important issue that medical staff must pay attention to. In this context, this paper carries out research, and uses five-tone therapy combined with acupressure diagnosis and treatment mode as an effective method to solve the pain problem of colonoscopy. Through analyzing its intervention process and implementation methods, the diagnosis and treatment effects are further analyzed.
Digital Geological Map of the Upper Laja River Basin, Guanajuato, Mexico
Authors: Beltrán Martínez Beatriz Coral , Aguirre Isidro Loza , Li Yanmei , Avilés Raúl Miranda , Samaniego Ángel Nieto , Moreno Edgar Ángeles , Kshirsagar Pooja Vinod , Alquiza María Jesús Puy , Anguiano Jesús Horacio Hernández
Published: January 2024

A new geological map of the Upper Laja River Basin at 1:200,000 scale is presented, covering an area of ∼11,600 km2 in the northern part of Guanajuato. This map was edited based on local and regional geological studies available in the literature, photo interpretations, field verification of contacts and faults and structural data acquisition. The main objective of this map is to provide a regional geological framework for future local geological and hydrological studies in the region. It displays the geology of the basin, divided into seven chronostratigraphic groups, as well as the main faults that shape the basin. In contribution to the geological knowledge of the area, five new U-Pb ages are presented, obtained from samples collected at the eastern and western edges of the basin.
PREPARAÇÃO DE CARVÃO ATIVADO A PARTIR DA PIRÓLISE DE VAGENS DE FLAMBOYANT (Delonix regia)
Authors: Pedroza Marcelo Mendes , Silva Alexandre Cotrin da , Barros Pedro Alexandre Pinto Cerqueira , Rezende Cláudia da Silva Aguiar , Lôbo Ranyere do Nascimento , Arruda Matheus Gomes
Published: January 2024

Nos últimos anos uma crescente problemática que vem ganhando espaço é a questão envolvida com os resíduos produzidos pelas atividades humanas.  A quantidade de resíduos sólidos produzidos e coletados diariamente tem tomado proporções preocupantes, visto que se não forem corretamente destinados, esses resíduos podem causar danos ao meio ambiente, e aos próprios seres humanos, sendo necessária a busca por novas tecnologias para reutilização de resíduos sólidos. O flamboyant (Delonix regia), é uma espécie ornamental muito utilizada para fins de paisagismo, devido a sua beleza. Os resíduos de poda do flamboyant podem ser expressivos, devido a sua quantidade em diversos locais. Este trabalho teve como objetivo utilizar o resíduo da poda de flamboyant no processo de pirólise para a produção de carvão ativado. A biomassa foi caracterizada através das análises imediatas: material volátil (84.56%), cinzas (3.84%) e carbono fixo (11.57%). Os experimentos de pirólise do resíduo foram realizados em reator de leito fixo, em duas temperaturas diferentes (350 e 550 oC) durante 30 minutos de degradação térmica na qual foram obtidas um rendimento da massa inicial do resíduo de 25.99% para a pirólise a 550 °C e de 35.49% para a pirólise a 350°C. Após os ensaios de pirólise, as amostras de carvão obtidas durante o processo foram coletadas, armazenadas e caracterizadas pelas mesmas técnicas analíticas empregadas com a biomassa in natura além do teste de adsorção de azul de metileno em mesa agitadora orbital no qual foi utilizado o planejamento multivariável do delineamento de faces centradas com 7 tipos de combinações de massa e concentração de corante, onde todos os resultados tiveram mais de 80% de eficiência, sendo o maior deles de 85.93%.
PROPOSTA DE ÍNDICE DE TRATAMENTO DE ESGOTO SANITÁRIO PARA ESTAÇÕES COM A TECNOLOGIA UASB NO MUNICÍPIO DE FORTALEZA, CE
Authors: Oliveira Helenamara Fonseca Sobrinho de , Nunes Ana Bárbara de Araújo
Published: January 2024

As Estações de Tratamento de Efluentes (ETEs) têm a função de promover o tratamento das águas residuárias, logo sendo uma opção para a mitigação da escassez hídrica. Algumas dessas estações, porém, possuem problemas no monitoramento e na avaliação dos seus processos de tratamento, descartando os seus efluentes em desacordo com as legislações ambientais de lançamento, logo prejudicando a saúde dos corpos hídricos. O objetivo deste trabalho consistiu na construção de um índice de tratamento de esgoto sanitário (ITES), como uma ferramenta inovadora, que analisou qualitativamente parâmetros com base nas legislações ambientais e auxiliaria na tomada de decisão quanto ao lançamento dos efluentes das ETEs. Para isto, foram escolhidas onze estações, que operam com a tecnologia reator anaeróbio de fluxo ascendente e manta de lodo (UASB), localizadas em Fortaleza-CE, visando avaliar os seus dados de efluentes tratados entre 2016 e 2020. O índice foi construído utilizando análise de componentes principais e as estações foram classificadas, com base no atendimento das legislações ambientais, em três classes: insatisfatório, satisfatório e excelente. A partir da análise dos índices aplicados, quatros estações foram classificadas como insatisfatórias, quatro como satisfatórias e três com atendimento excelente as legislações avaliadas. Portanto, o índice representou objetivamente os efluentes e auxiliou a tomada de decisão quanto ao lançamento em corpos hídricos.
PRÉ-TRATAMENTO DE LIXIVIADO DE ATERRO SANITÁRIO POR ALCALINIZAÇÃO E PRECIPITAÇÃO QUÍMICA
Authors: Gomes Naiara Angelo , Calixto Nayr Thays Henrique , Silva Elisângela Maria da , Ribeiro Libânia da Silva , Monteiro Veruschka Escarião Dessoles , Melo Márcio Camargo de
Published: January 2024

Este trabalho teve como objetivo estudar a viabilidade ambiental da aplicação da cal hidratada comercial do tipo I (CH-I) e do hidróxido de sódio padrão analítico (NaOH P.A) em processos de alcalinização/ precipitação química utilizando lixiviado de aterro sanitário. Para isso, no mês de maio/2021, coletou-se aproximadamente 1 m3 de lixiviado no Aterro Sanitário em Campina Grande (ASCG), Paraíba, Brasil, em caminhão-tanque, o qual foi armazenado em um reservatório de polietileno, nas dependências físicas da Universidade Federal de Campina Grande, Campus Sede. Posteriormente, cerca de 0.001 m3 de lixiviado foram coletados, em triplicata, para a realização dos ensaios de alcalinização, que tiveram por finalidade aumentar o potencial hidrogeniônico (pH) do referido efluente para 10 ± 1 e 12 ± 1 e verificar a precipitação química do cobre (Cu), cromo (Cr) e níquel (Ni) total, bem como a remoção de cor, turbidez e nitrogênio amoniacal total (NAT), utilizando a CH-I e o NaOH P.A. Os resultados retrataram que foram necessários 28.45 g de CH-I e 5.59 g de NaOH P.A para elevar o pH do lixiviado à 10 ± 1. Em relação ao aspecto econômico, é mais vantajoso usar a CH-I no processo de alcalinização/precipitação química, pois seu custo foi cerca de 12 (pH = 10 ± 1) e 17 (pH = 12 ± 1) vezes menor em relação ao NaOH P.A. Observou-se que a CH-I apresentou o melhor desempenho na redução de cor aparente (60 a 90%) e NAT (> 8%), e teve eficiência similar ao NaOH P.A na remoção do Cr (pH = 12 ± 1), Cu e Ni, alcançando valores superiores a 30, 90 e 40%, respectivamente. Diante dos resultados expostos, concluiu-se que, tanto do ponto de vista econômico, quanto ambiental, a CH-I demonstrou ser a melhor espécie química a ser aplicada em processos de alcalinização/precipitação utilizando lixiviado de aterro sanitário de região Semiárida.
IMPOSEX EM Stramonita brasiliensis (MOLLUSCA: GASTROPODA) EM TERMINAIS PORTUÁRIOS DO CEARÁ: AVALIAÇÃO E PERCEPÇÃO AMBIENTAL
Authors: Santos Marcos Roberto dos , Maia Rafaela Camargo
Published: January 2024

O imposex consiste no aparecimento de estruturas sexuais masculinas em fêmeas de gastrópodes expostos a contaminação por Compostos Orgânicos de Estanho (COEs). Os moluscos do gênero Stramonita são altamente sensíveis a esse composto, fazendo deste táxon o bioindicador mundial da contaminação. O objetivo do estudo foi avaliar a percepção ambiental dos pescadores sobre a origem e utilização dos COEs em áreas portuárias do litoral oeste do Ceará. Foram avaliados quatro portos pesqueiros, em cada ponto foram coletados e avaliados 50 exemplares da espécie. Também foram realizadas entrevistas para compreender a origem e utilização do composto com pescadores, donos de embarcações e empresários do setor de tintas. Dos quatro portos pesqueiros avaliados no estudo, em três observou-se a incidência de imposex na espécie Stramonita brasilienses. No Porto Pesqueiro de Acaraú, a espécie não foi registrada, o que pode ser resultado de anos de utilização de COEs. A maior incidência de imposex foi registrada na Praia da Pedra Rachada em Paracuru (69,44%), seguido pelo Porto dos Barcos em Itarema, (69.18%) e Porto Pesqueiro de Camocim, que apresentou menor incidência da síndrome (51.22%). Os dados obtidos durante as entrevistas revelaram que mesmo após o banimento do uso de COEs em tintas anti-incrustantes, a substância continua chegando aos portos por meio de fontes alternativas tais inseticidas legalmente comercializados. A presença de imposex nessas amostras sugere fortemente que as referidas áreas estão contaminadas por COEs. Estudos baseados no desenvolvimento do imposex são importantes ferramentas no monitoramento das condições ambientais e conservação da biodiversidade.
Research Results of Municipal Sewage Sludge Applied for Building Material Production
Authors: Parshikova M. V. , Lagutina E. L. , Yakovlev G. I. , Gordina A. F. , Lagutin I. E.
Published: January 2024

The study presents the experimental results on the use of ash obtained as a result of incineration of municipal sewage sludge from the water utility of Izhevsk, Udmurt Republic, for construction material production. Research methods are given and the results of strength tests of building material samples are given. The impact of the manufactured samples of construction materials on the ecology of the surrounding space and human health is assessed. To achieve the set objectives of the research laboratory experiment and determination of indicators of investigated values of sludge, ash and water extracts with the use of devices and measuring instruments are used. On the basis of the research laboratories of Kalashnikov Izhevsk State Technical University and MUE “IzhVodokanal” of the Udmurt Republic experimental studies on incineration of sewage sludge and the use of the resulting ash as a substituting or modifying component of the construction mixture in the manufacture of experimental samples of ceramics, cement-sand mortar and concrete were carried out. Methodology of manufacturing and algorithm of ceramic (fired) and cement-based (nonfired) testing specimens are presented. Measuring means for determination of gamma-radiation intensity indices of ash, cement and their influence on human health are used. The algorithm of experimental research, applied energy-efficient techniques used in the experiment and analysis of the obtained experimental results are presented. The analysis of experimental research results of ceramic and cement-based products, as well as the analysis of radiation safety, migration of heavy metals is presented. The energy-efficient methodology of sewage sludge utilization and further ways of applying ash as an environmental and resource-saving component used in manufacturing of experimental building materials are considered.
Wind Power Plant Efficiency Increasing Methods in Ice Formation on Wind Wheels Blades
Authors: Buyalsky V. I.
Published: January 2024

Effective automated control method relevance of wind power plant in ice formation on wind wheel blades is justified for different operation modes, to minimize transient time of regulation of wind turbine rotor angular speed, so as to increase the stability of wind wheel rotation speed and to improve reliability indicators of modern wind power plant components at incomplete information of wind speed, the electric loading characteristics being changed significantly with time. The review of basic ways of wind power plant control for regions with severe winters and wind unit operation has a number of the problems related to ice formation on wind wheel blades is made. The description of mathematical relation of wind turbine specific speed, ice thickness on wind wheel blades, wind speeds and blade position angle that provide the required specific speed wind turbine within the range of operating wind speed is made. The analysis of specific speed change based on numerical test results of mathematical relation of wind turbine specific speed and ice thickness on wind wheel blades, wind speeds and blade position angle has revealed that ice formation at an edge of wind wheel blades h=0.005 m has negative effect on angular speed stability of power plant rotor with the mismatch error exceeding 2% which is inadmissible and leads to fluctuations of wind wheel rotation speed and transient time increase. A step-by-step algorithm to determine angular speed of wind turbine rotor with respect to ice thickness formed on wind wheel blades is developed, as it realizes all formulae and information components necessary for measurement and transformation of data with the subsequent development of operating influences of increasing of wind power plant efficiency.
Patent Landscape Study Results in Relation to Analyzing and Optimizing Methods and Devices for Technological Processes
Authors: Danilova A. A. , Dombrachev A. N.
Published: January 2024

Difficult economic situation that has developed for most Russian companies in the market today requires new ways of ensuring their competitiveness, including import substitution of high-tech products previously being produced by foreign corporations in such industries as: machine-tool engineering, heavy engineering, textile production, electronic industry and medical production. Today, there are many different tools that help improve the company efficiency, including engineering enterprises, one of them is the audit of their production processes. Audit being a tool to implement the concept of business management process rationalization, also known as «lean production», allows you to monitor and adjust changes in technological processes, clarify planned production programs and make justified and balanced management decisions; in domestic research, the concept of rationalizing business process management is also commonly called scientific labor organization (SLO). The real interest of enterprises to the development of existing and design of new audit methods, as well as the need to create technical means for implementing these methods in practice, can be assessed by both on the basis of information search for scientific and technical documents devoted to effectiveness evaluation of production systems, published in peer-reviewed journals or in the form of monographs, and based on an analysis of the patent activity of technical solutions applicable for the implementation of lean manufacturing tools in production conditions. In this article, the authors examine the results of information and analytical studies of patent activity in the field of methods and devices for analyzing and optimizing technological processes for manufacturing high-tech products at mechanical engineering enterprises.
Dynamic Inventory Management Model for Equipment Replacement with Probabilistic Distribution of Failures
Authors: Zakharychev M. Yu. , Tenenev V. A. , Vologdin S. V.
Published: January 2024

The article deals with the issues of inventory management modeling of components to ensure the prompt replacement of deep-water pump installations for the oilfield industry in case of equipment failure. The review of literary sources on the subject of the study and the problem statement is given. The rationale for choosing a mathematical model for problem solution is given. The task of dynamic inventory management is to provide the necessary stock with minimal temporary losses from forced downtime at minimal component storage and supply cost for repair or replacement. The planning horizon is divided into several time periods where optimal amount of inventory is to be ensured. It is indicated that when planning stocks in the case of a large number of pieces of equipment operating under different conditions, it is advisable to use a probabilistic approach. An event distribution function is set for probabilistic flow of equipment shutdown. The problem is solved for each segment defining the margin value by means of the Wilson model for deterministic flow of events. The results of simulation modeling on the shutdowns of electric drive centrifugal pump installations at the wells of the Vyngapurovskoye field are presented. A histogram of equipment shutdown frequencies for various time intervals is given. An exponential best approximation function is constructed to approximate the number of stops from installation time to equipment stop, the function coefficients and the standard approximation error are calculated. The characteristic curve of the relative proportion of the operating equipment requiring replacement, as well as the planned number of installations supplied for equipment replacement, with time is given. The dynamics of safety margin changes, which ensures the guaranteed replacement of failed equipment on time with respect to time, is presented.