bluuebunny/crossref_metadata_2025 huggingface dataset:
Gratitude and Religiosity in Psychiatric Inpatients with Depression
Authors: Vandeventer Silas R. S. , Rufer Michael , Eglin Micha , Koenig Harold G. , Hefti René
Published: January 2024

Background. Gratitude and religiousness/spirituality are increasingly recognized resources that have potential influence on psychological states such as depression. However, only few studies have investigated this relationship in psychiatric patients. Objective. The present study examined gratitude in psychiatric inpatients with depression, exploring its relevance, course, and interaction with psychopathological and religious measures. Both general and religious gratitude will be evaluated. Methods. A total of 212 inpatients with depression completed a questionnaire both at the beginning and the end of treatment. Gratitude was measured with a general gratitude scale using the Gratitude Questionnaire and a religion-specific measure assessing gratitude to God as part of the Structure of Religiosity Test. The Beck Depression Inventory was used to evaluate depressive symptoms. General religiosity was assessed using the Centrality of Religiosity Scale. Results. Scores on the general and religious gratitude measures were in the upper range of these scales at baseline and demonstrated a significant increase during the hospital stay. Negative associations were found between general gratitude and depressive symptoms both on admission and at discharge (r=−0.505 and r=−0.478, respectively). General as well as religious gratitude was associated with the centrality of religiosity (r=0.384 and r=0.546, respectively). Religiosity accounted for approximately 10% of the variance in general gratitude on admission. Conclusions. Gratitude is highly prevalent in psychiatric patients with depression, and that may serve as a resource for these individuals. Both general and religious gratitude are associated with religiosity, which may also serve as a resource to these patients.
Table S6 from Early Cancer Detection in Li–Fraumeni Syndrome with Cell-Free DNA
Authors: Wong Derek , Luo Ping , Oldfield Leslie E. , Gong Haifan , Brunga Ledia , Rabinowicz Ron , Subasri Vallijah , Chan Clarissa , Downs Tiana , Farncombe Kirsten M. , Luu Beatrice , Norman Maia , Sobotka Julia A. , Uju Precious , Eagles Jenna , Pedersen Stephanie , Wellum Johanna , Danesh Arnavaz , Prokopec Stephenie D. , Stutheit-Zhao Eric Y. , Znassi Nadia , Heisler Lawrence E. , Jovelin Richard , Lam Bernard , Lujan Toro Beatriz E. , Marsh Kayla , Sundaravadanam Yogi , Torti Dax , Man Carina , Goldenberg Anna , Xu Wei , Veit-Haibach Patrick , Doria Andrea S. , Malkin David , Kim Raymond H. , Pugh Trevor J.
Published: January 2024

Supplemental Table 6 – Breast Cancer Methylation Signature
Figure S8 from Early Cancer Detection in Li–Fraumeni Syndrome with Cell-Free DNA
Authors: Wong Derek , Luo Ping , Oldfield Leslie E. , Gong Haifan , Brunga Ledia , Rabinowicz Ron , Subasri Vallijah , Chan Clarissa , Downs Tiana , Farncombe Kirsten M. , Luu Beatrice , Norman Maia , Sobotka Julia A. , Uju Precious , Eagles Jenna , Pedersen Stephanie , Wellum Johanna , Danesh Arnavaz , Prokopec Stephenie D. , Stutheit-Zhao Eric Y. , Znassi Nadia , Heisler Lawrence E. , Jovelin Richard , Lam Bernard , Lujan Toro Beatriz E. , Marsh Kayla , Sundaravadanam Yogi , Torti Dax , Man Carina , Goldenberg Anna , Xu Wei , Veit-Haibach Patrick , Doria Andrea S. , Malkin David , Kim Raymond H. , Pugh Trevor J.
Published: January 2024

Figure S8 showing cfMeDIP quality control metrics
Figure S1 from Early Cancer Detection in Li–Fraumeni Syndrome with Cell-Free DNA
Authors: Wong Derek , Luo Ping , Oldfield Leslie E. , Gong Haifan , Brunga Ledia , Rabinowicz Ron , Subasri Vallijah , Chan Clarissa , Downs Tiana , Farncombe Kirsten M. , Luu Beatrice , Norman Maia , Sobotka Julia A. , Uju Precious , Eagles Jenna , Pedersen Stephanie , Wellum Johanna , Danesh Arnavaz , Prokopec Stephenie D. , Stutheit-Zhao Eric Y. , Znassi Nadia , Heisler Lawrence E. , Jovelin Richard , Lam Bernard , Lujan Toro Beatriz E. , Marsh Kayla , Sundaravadanam Yogi , Torti Dax , Man Carina , Goldenberg Anna , Xu Wei , Veit-Haibach Patrick , Doria Andrea S. , Malkin David , Kim Raymond H. , Pugh Trevor J.
Published: January 2024

Figure S1 showing extended cohort descriptions.
Figure S9 from Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function
Authors: Jain Nayan , Zhao Zeguo , Koche Richard P. , Antelope Chenling , Gozlan Yosi , Montalbano Antonino , Brocks David , Lopez Michael , Dobrin Anton , Shi Yuzhe , Gunset Gertrude , Giavridis Theodoros , Sadelain Michel
Published: January 2024

Figure S9. Enhanced TCF1 and LEF1 expression in SUV39H1-edited CAR T cells under conditions of repeated stimulation.
Figure S7 from Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function
Authors: Jain Nayan , Zhao Zeguo , Koche Richard P. , Antelope Chenling , Gozlan Yosi , Montalbano Antonino , Brocks David , Lopez Michael , Dobrin Anton , Shi Yuzhe , Gunset Gertrude , Giavridis Theodoros , Sadelain Michel
Published: January 2024

Figure S7. SUV39H1 disruption, over time, improves expansion and cytolytic capacity of CAR T cells under conditions of repeated stimulation.
Figure S2 from Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function
Authors: Jain Nayan , Zhao Zeguo , Koche Richard P. , Antelope Chenling , Gozlan Yosi , Montalbano Antonino , Brocks David , Lopez Michael , Dobrin Anton , Shi Yuzhe , Gunset Gertrude , Giavridis Theodoros , Sadelain Michel
Published: January 2024

Figure S2.SUV39H1 disruption does not improve anti-tumor efficacy of non-functional/non-specific CAR.
Supplementary Fig 5 from Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells
Authors: He Chunbo , Wang Dezhen , Shukla Surendra K. , Hu Tuo , Thakur Ravi , Fu Xiao , King Ryan J. , Kollala Sai Sundeep , Attri Kuldeep S. , Murthy Divya , Chaika Nina V. , Fujii Yuki , Gonzalez Daisy , Pacheco Camila G. , Qiu Yudong , Singh Pankaj K. , Locasale Jason W. , Mehla Kamiya
Published: January 2024

Supplementary Figure S5 shows that VB6 regulates the mobilization of glycogen to promote glycolysis in NK cells upon acute stimulation with target cells.
Supplementary Fig 4 from Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells
Authors: He Chunbo , Wang Dezhen , Shukla Surendra K. , Hu Tuo , Thakur Ravi , Fu Xiao , King Ryan J. , Kollala Sai Sundeep , Attri Kuldeep S. , Murthy Divya , Chaika Nina V. , Fujii Yuki , Gonzalez Daisy , Pacheco Camila G. , Qiu Yudong , Singh Pankaj K. , Locasale Jason W. , Mehla Kamiya
Published: January 2024

Supplementary Figure S4 shows that inhibition of glycogenolysis blocks VB6-mediated increased NKs effector function.
Supplementary Table S2 from Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study
Authors: Kelly William K. , Danila Daniel C. , Lin Chia-Chi , Lee Jae-Lyun , Matsubara Nobuaki , Ward Patrick J. , Armstrong Andrew J. , Pook David , Kim Miso , Dorff Tanya B. , Fischer Stefanie , Lin Yung-Chang , Horvath Lisa G. , Sumey Christopher , Yang Zhao , Jurida Gabor , Smith Kristen M. , Connarn Jamie N. , Penny Hweixian L. , Stieglmaier Julia , Appleman Leonard J.
Published: January 2024

Supplementary Table S2: Supplementary Table S2 showing antidrug antibody (ADA) impact to landmark prostate-specific antigen response (PSA50) at 12 weeks.
Supplementary Figure S1 from Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study
Authors: Kelly William K. , Danila Daniel C. , Lin Chia-Chi , Lee Jae-Lyun , Matsubara Nobuaki , Ward Patrick J. , Armstrong Andrew J. , Pook David , Kim Miso , Dorff Tanya B. , Fischer Stefanie , Lin Yung-Chang , Horvath Lisa G. , Sumey Christopher , Yang Zhao , Jurida Gabor , Smith Kristen M. , Connarn Jamie N. , Penny Hweixian L. , Stieglmaier Julia , Appleman Leonard J.
Published: January 2024

Supplementary Figure S1: Supplementary Figure S1 showing study schema for xaluritamig intravenous monotherapy dose exploration and expansion phases.
Supplementary Table 3 from SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors
Authors: López-Cobo Sheila , Fuentealba Jaime R. , Gueguen Paul , Bonté Pierre-Emmanuel , Tsalkitzi Kyriaki , Chacón Irena , Glauzy Salomé , Bohineust Armelle , Biquand Ariane , Silva Lisseth , Gouveia Zelia , Goudot Christel , Perez Franck , Saitakis Michael , Amigorena Sebastian
Published: January 2024

Differentially expressed genes between mock and gSUV clusters in CD8+ and CD4+ T cells. Related to Figures 3, 4, S4, S5.
Supplementary Tables and Figure from Mobilizing China and the Global Community to Confront the Treatment Desert for Pediatric Solid Tumors
Authors: Wang Shuhang , Jiang Yale , Zheng Rongshou , Yu Yue , Wei Wenqiang , Li Ning
Published: January 2024

Supplementary tables
- Table S1. Incidence and survival rates for childhood cancers in China, 2014 -2018+
- Table S2. Drugs approved for pediatric solid tumors by FDA
- Table 3. Drugs officially approved for pediatric solid tumors by NMPA in China
Supplementary figure
- Supplement Figure S1. The distribution of incidence divided by cancer types during 2014-2018 in China
Supplementary Table 1 from SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors
Authors: López-Cobo Sheila , Fuentealba Jaime R. , Gueguen Paul , Bonté Pierre-Emmanuel , Tsalkitzi Kyriaki , Chacón Irena , Glauzy Salomé , Bohineust Armelle , Biquand Ariane , Silva Lisseth , Gouveia Zelia , Goudot Christel , Perez Franck , Saitakis Michael , Amigorena Sebastian
Published: January 2024

List of OFF-target sites for Suv-1 gRNA. Differentially expressed genes between mock and gSUV CD8+ T cells by Nanostring. Related to Figures 1 and S1, S2.
Table S6 from Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
Authors: Suehnholz Sarah P. , Nissan Moriah H. , Zhang Hongxin , Kundra Ritika , Nandakumar Subhiksha , Lu Calvin , Carrero Stephanie , Dhaneshwar Amanda , Fernandez Nicole , Xu Benjamin W. , Arcila Maria E. , Zehir Ahmet , Syed Aijazuddin , Brannon A. Rose , Rudolph Julia E. , Paraiso Eder , Sabbatini Paul J. , Levine Ross L. , Dogan Ahmet , Gao Jianjiong , Ladanyi Marc , Drilon Alexander , Berger Michael F. , Solit David B. , Schultz Nikolaus , Chakravarty Debyani
Published: January 2024

Table S6: Gene-alteration-tumor types associated with an OncoKB Therapeutic Level of Evidence (Levels 1-4) in March 2017, and changes made to the dataset to ensure 2017 OncoKB clinically actionable variants are consistent with the OncoKB Standard Operating Procedure v2.2.
Table S2 from Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
Authors: Suehnholz Sarah P. , Nissan Moriah H. , Zhang Hongxin , Kundra Ritika , Nandakumar Subhiksha , Lu Calvin , Carrero Stephanie , Dhaneshwar Amanda , Fernandez Nicole , Xu Benjamin W. , Arcila Maria E. , Zehir Ahmet , Syed Aijazuddin , Brannon A. Rose , Rudolph Julia E. , Paraiso Eder , Sabbatini Paul J. , Levine Ross L. , Dogan Ahmet , Gao Jianjiong , Ladanyi Marc , Drilon Alexander , Berger Michael F. , Solit David B. , Schultz Nikolaus , Chakravarty Debyani
Published: January 2024

A list of precision oncology therapies (per the definition provided in the manuscript) approved by the US FDA between January 1998 and November 2022, as well as the year each drug was first FDA approved, the FDA-recognized biomarker(s), the method of biomarker detection, and classification of each drug as first-in-class, mechanistically-distinct, follow-on, or resistance (per definitions provided in the manuscript).
Supplementary Table S4 from AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer
Authors: Nolan-Stevaux Olivier , Li Cong , Liang Lingming , Zhan Jinghui , Estrada Juan , Osgood Tao , Li Fei , Zhang Hanzhi , Case Ryan , Murawsky Christopher M. , Estes Bram , Moore Gregory L. , Bernett Matthew J. , Muchhal Umesh , Desjarlais John R. , Staley Binnaz K. , Stevens Jennitte , Cooke Keegan S. , Aeffner Famke , Thomas Oliver , Stieglmaier Julia , Lee Jae-Lyun , Coxon Angela , Bailis Julie M.
Published: January 2024

Summary of STEAP1 mRNA and Protein Expression in Normal Tissues.
Figure S1 from Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
Authors: Suehnholz Sarah P. , Nissan Moriah H. , Zhang Hongxin , Kundra Ritika , Nandakumar Subhiksha , Lu Calvin , Carrero Stephanie , Dhaneshwar Amanda , Fernandez Nicole , Xu Benjamin W. , Arcila Maria E. , Zehir Ahmet , Syed Aijazuddin , Brannon A. Rose , Rudolph Julia E. , Paraiso Eder , Sabbatini Paul J. , Levine Ross L. , Dogan Ahmet , Gao Jianjiong , Ladanyi Marc , Drilon Alexander , Berger Michael F. , Solit David B. , Schultz Nikolaus , Chakravarty Debyani
Published: January 2024

Highest OncoKB level of evidence per (a) tumor type and per (b) tumor type and gene for a subset of solid tumor samples from the MSK-IMPACT cohort with n≥100.
Data from Mobilizing China and the Global Community to Confront the Treatment Desert for Pediatric Solid Tumors
Authors: Wang Shuhang , Jiang Yale , Zheng Rongshou , Yu Yue , Wei Wenqiang , Li Ning
Published: January 2024

Summary:
Pediatric solid tumors are distinct clinical entities that impose heavy socioeconomic burden and while their incidence has increased in recent years, treatment options are often limited, with only 27 drugs approved for pediatric solid tumors in the United States, and fewer still, 13, in China. The scale of the unmet medical need is immense and new efforts are urgently needed to develop efficient therapeutics and improve these children's lives.
Data from Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
Authors: Suehnholz Sarah P. , Nissan Moriah H. , Zhang Hongxin , Kundra Ritika , Nandakumar Subhiksha , Lu Calvin , Carrero Stephanie , Dhaneshwar Amanda , Fernandez Nicole , Xu Benjamin W. , Arcila Maria E. , Zehir Ahmet , Syed Aijazuddin , Brannon A. Rose , Rudolph Julia E. , Paraiso Eder , Sabbatini Paul J. , Levine Ross L. , Dogan Ahmet , Gao Jianjiong , Ladanyi Marc , Drilon Alexander , Berger Michael F. , Solit David B. , Schultz Nikolaus , Chakravarty Debyani
Published: January 2024

Abstract
There is a continuing debate about the proportion of cancer patients that benefit from precision oncology, attributable in part to conflicting views as to which molecular alterations are clinically actionable. To quantify the expansion of clinical actionability since 2017, we annotated 47,271 solid tumors sequenced with the MSK-IMPACT clinical assay using two temporally distinct versions of the OncoKB knowledge base deployed 5 years apart. Between 2017 and 2022, we observed an increase from 8.9% to 31.6% in the fraction of tumors harboring a standard care (level 1 or 2) predictive biomarker of therapy response and an almost halving of tumors carrying nonactionable drivers (44.2% to 22.8%). In tumors with limited or no clinical actionability, TP53 (43.2%), KRAS (19.2%), and CDKN2A (12.2%) were the most frequently altered genes.
Significance:
Although clear progress has been made in expanding the availability of precision oncology-based treatment paradigms, our results suggest a continued unmet need for innovative therapeutic strategies, particularly for cancers with currently undruggable oncogenic drivers.

See related commentary by Horak and Fröhling, p. 18.

This article is featured in Selected Articles from This Issue, p. 5
Supplementary Table S8 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

This file is a list of abbreviations found in the manuscript
Supplementary Table S7 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

This file contains the t-tests performed on the PROGENy activity scores.
Supplementary Table S6 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

This file contains the PROGENy Activity Score Results from both cohorts for each signalling pathway analysed.
Supplementary Table S1 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

This file is the entire list of clinical data for both patient cohorts used in the study.
Supplementary Figure S8 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

Supplementary Figure S8 shows the PROGENy pathway activity scores from the mRNA expressions for Black/AA and White patient cohorts
Supplementary Figure S5 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

Supplementary Figure S5 shows the distribution of the log2 Hazard Ratios from Black/AA and White cohorts
Supplementary Figure S4 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

Supplementary Figure S4 shows the probability of overall survival for the MSI MANTIS Scores for each patient cohort
Supplementary Figure S2 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

Supplementary Figure S2 shows the MSI MANTIS Score for each patient cohort Black/AA and White
Supplementary Figure S1 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

Supplementary Figure S1 shows the distributions of the number of patients in each race categories from the TCGA PanCancer Atlas dataset
Data from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

Abstract
Racial disparities between Black/African Americans (AA) and White patients in colorectal cancer are an ever-growing area of concern. Black/AA show the highest incidence and have the highest mortality among major U.S. racial groups. There is no definite cause other than possible sociodemographic, socioeconomic, education, nutrition, delivery of healthcare, screening, and cultural factors. A primary limitation in this field is the lack of and small sample size of Black/AA studies. Thus, this study aimed to investigate whether differences in gene expression contribute to this ongoing unanswered racial disparity issue. In this study, we examined transcriptomic data of Black/AA and White patient cohorts using a bioinformatic and systems biology approach. We performed a Kaplan–Meier overall survival analysis between both patient cohorts across critical colorectal cancer signal transduction networks (STN), to determine the differences in significant genes across each cohort. Other bioinformatic analyses performed included PROGENy (pathway responsive genes for activity inference), RNA sequencing differential expression using DESeq2, multivariable-adjusted regression, and other associated Kaplan–Meier analyses. These analyses identified novel prognostic genes independent from each cohort, 176 differentially expressed genes, and specific patient cohort STN survival associations. Despite the overarching limitation, the results revealed several novel differences in gene expression between the colorectal cancer Black/AA and White patient cohorts, which allows one to dive deeper into and understand the behavior on a systems level of what could be driving this racial difference across colorectal cancer. Concretely, this information can guide precision medicine approaches tailored specifically for colorectal cancer racial disparities.
Significance:
The purpose of this work is to investigate the racial disparities in colorectal cancer between Black/AA and White patient cohorts using a systems biology and bioinformatic approach. Our study investigates the underlying biology of each patient cohort. Concretely, the findings of this study include disparity-associated genes and pathways, which provide a tangible starting point to guide precision medicine approaches tailored specifically for colorectal cancer racial disparities.
Evidence of Hypothalamic-Pituitary-Adrenal and -Gonadal Dysfunction in Cocaine-Addicted Men
Authors: Ersche Karen D. , Stochl Jan , Brühl Annette B. , Gurnell Mark
Published: January 2024

Introduction: Regular cocaine use has been associated with hormonal dysfunction including hypogonadism, which can lead to fatigue, reduced stamina, sexual dysfunction, and impaired quality of life. However, cocaine’s endocrine effects are largely under-reported in the scientific addiction literature and, in many cases, are not addressed within treatment services. The low profile of these adverse effects might be attributable to a lack of awareness and linkage with cocaine use, such that they are recognized only when an acute/emergency problem arises. Methods: We assessed endocrine diurnal function (adrenocorticotrophic hormone [ACTH], cortisol, and testosterone) in 26 healthy and 27 cocaine-dependent men and examined changes in hormone levels in response to a single 40 mg dose of the noradrenaline re-uptake inhibitor atomoxetine in a double-blind, placebo-controlled experimental medicine study. Results: When compared with healthy controls, diurnal and atomoxetine-induced changes in ACTH and cortisol showed greater variability in cocaine-dependent men. Interestingly, despite an exaggerated rise in ACTH following atomoxetine, an attenuated cortisol response was observed, and one-third of cocaine-dependent men had subnormal testosterone levels. Conclusion: Our findings point to a potential disconnection between the pituitary and adrenal responses in cocaine-dependent men, a higher rate of hypogonadism, and a pressing need for more research into the endocrine effects of cocaine and their clinical implications.
A Novel Method Using Gadolinium-Ethoxybenzyl Diethylenetriamine Pentaacetate Acid-Enhanced Magnetic Resonance Imaging for Predicting Post-Hepatectomy Liver Failure in Hepatocellular Carcinoma Patients with a Major Portal Vein Tumor Thrombus
Authors: Nishio Kosuke , Komatsu Shohei , Sofue Keitaro , Kido Masahiro , Kuramitsu Kaori , Gon Hidetoshi , Fukushima Kenji , Urade Takeshi , Yanagimoto Hiroaki , Toyama Hirochika , Fukumoto Takumi
Published: January 2024

Introduction: The usefulness of gadolinium-ethoxybenzyl diethylenetriamine pentaacetate acid-enhanced magnetic resonance imaging (EOB-MRI) in assessing the functional future remnant liver volume (fFRLV) to predict post-hepatectomy liver failure (PHLF) has been previously reported. Herein, we evaluated the efficacy of this technique in patients with hepatocellular carcinoma (HCC) with a major portal vein tumor thrombus (PVTT). Methods: This study included 21 patients with PVTT in the ipsilateral first-order branch (Vp3) and 30 patients with PVTT in the main trunk/contralateral branch (Vp4). To evaluate fFRLV, the signal intensity (SI) of the remnant liver was determined on T1-weighted images, using both conventional and newly developed methods. The fFRLV was calculated using the SI of the remnant liver and muscle, remnant liver volume, and body surface area. Preoperative factors predicting PHLF (≥grade B) in HCC patients with Vp3/4 PVTT were evaluated. Results: In the Vp3 group, we found fFRLV area under the receiver-operating characteristic curves (AUCs) above 0.70 (AUC = 0.875, 0.750) using EOB-MRI results calculated using either the plot or whole method. None of the parameters in the Vp4 group had an AUC greater than 0.70. Conclusion: The fFRLV calculated by EOB-MRI using the whole method can be as useful as the conventional method in predicting PHLF (≥grade B) for HCC patients with Vp3 PVTT.
Medically Unexplained Symptoms Are Linked to Chronic Inflammatory Diseases: Is There a Role for Frontal Cerebral Blood Oxygen Content?
Authors: Straub Rainer H. , Boschiero Dario
Published: January 2024

Introduction: Patients often go to the physician with medically unexplained symptoms (MUS). MUS can be autonomic nervous system-related “unspecific” symptoms, such as palpitations, heart rhythm alterations, temperature dysregulation (hand, feet), anxiety, or depressive manifestations, fatigue, somnolence, nausea, hyperalgesia with varying pains and aches, dizziness, etc. Methods: In this real-world study, we investigated MUS in a cohort of unselected outpatients from general practitioners in Italy. It was our aim to increase the understanding of MUS by using principal component analyses to identify any subcategories of MUS and to check a role of chronic inflammatory diseases. Additionally, we studied cerebral blood oxygen (rCBO2) and associations with MUS and chronic inflammatory disease. Results: Participants included 1,597 subjects (50.6 ± 0.4 years, 65%/35% women/men). According to ICD-10 codes, 137 subjects had chronic inflammatory diseases. MUS were checked by a questionnaire with a numeric rating scale and cerebral blood flow with optical techniques. The analyses of men and women were stratified. Psychological symptom severity was higher in the inflamed compared to the non-inflamed group (fatigue, insomnia in women and men; recent mood changes, daytime sleepiness, anxiety, apathy, cold hands only in women; abnormal appetite and heart rhythm problems only in men). Principal component analysis with MUS provided new subcategories: brain symptoms, gut symptoms, and unspecific symptoms. Brain and gut symptoms were higher in inflamed women and men. Chronic inflammatory diseases and pain were tightly interrelated in men and women (p < 0.0001). In women, not in men, average frontal rCBO2 content was higher in inflamed compared to non-inflamed subjects. In men, not in women, individuals with pain demonstrated a lower average frontal rCBO2 content compared to pain-free men. MUS did not relate to rCBO2 parameters. Conclusion: This study shows close relationships between MUS and chronic inflammatory diseases but not between MUS and rCBO2 parameters.
What does it mean to be asemiotic?
Authors: Sabitov Daniyar
Published: January 2024

Although some researchers consider semiotics as a universal epistemological approach (Gaines, 2015), calling something ‘asemiotic’ may be challenging. However, one can find such characteristics in semioticians' work. For example, Tartu semiotic school cofounders Juri M. Lotman and Boris A. Uspensky argue that asemiotic is a way how proper name functions within mythological consciousness (Lotman; Uspensky, 1973). Despite the fact that this characteristics may be found in other scholars‘ works, research of ‘asemiotic’ continues to be a marginal field in semiotic studies.Since the ‘semiotic’ (related to semiotics) is determined in theoretical frameworks in different ways, the ‘asemiotic’ similarly does not stick to one meaning . In other words, asemiotic postulates the absence of the semiotic in the sense in which the scholar understands the semiotics. Otherwise, incompatibility of the theoretical sequence may lead to methodological inaccuracy. This may happen when one perceives semiotics as a unified theory. Thus, while it is not an accepted term, ‘asemiotic’ may have different meanings depending on the perspective. This research will delve into, the use of ‘asemiotic’ in the works of Guattari and Deleuze (1987), Nöth (1995, 2000) and Lotman and Uspensky as well as try to identify the case when scholars resort to using ‘asemiotic’ in their works. One may find different approaches of use, from the auxiliary instrument through the method of interpretation to the core concept.
Is social semiotics a unitary research field? An introductory and comparative mapping of Argentinean, Brazilian, French, Italian and English-speaking semiotic approaches to social meaning-making
Authors: Barreneche Sebastián Moreno
Published: January 2024

In the 1980s, researchers from different academic circles around the world started paying attention to the functioning of the social realm with a focus on signification and sense-making. Since then, they have shown particular interest in  studying practices, interactions and spatiality, among other objects of study, as activities that convey social meaning and produce sense. This is how the field of social semiotics emerged within general semiotics. However, the emergence of this new research field occurred in a fragmented manner. Nowadays, English-speaking ‘social semiotics’ coexists with at least two French sociosémiotiques, with Argentinean sociosemiótica, with Italian sociosemiotica and with Brazilian sociossemiótica. This article examines these five accounts of social semiotics in a comparative manner with a focus on the theoretical and methodological references they use as their sources. Therefore, the article should function as an introductory roadmap for researchers within the social and human sciences interested in approaching contemporary social semiotics and sociosemiotic research.
On the institutional (dis)organisation of semiotics as a discipline
Authors: Herrera Eduardo Chávez
Published: January 2024

Semiotics, as the field dealing with the production of meaning-making mechanisms, was supposed to be a holistic project. Semioticians in the 20th century were concerned about providing semiotics an epistemological identity. For instance, semiotics was aimed at following a meta-role (Greimas, 1976) as ‘a metadiscipline of all academic disciplines’ (Posner, 2003, p. 2366). In fact, Sebeok (1976) deemed semiotics as a ‘doctrine of signs’, refusing to call it a science or a theory. Despite this sophisticated terminology, semiotics remained poorly organised in the national academic systems. This lack of organisation in the academic institutions did not allow semiotics to show this allegedly federative role of general knowledge. Instead, semiotics ended up receiving different designations such as ‘esoteric knowledge’, ‘cabalistic language’, ‘formalistic paranoia’, and so forth. This paper delves into the institutional disorganisation of semiotics by addressing two main aspects. Firstly, the lack of interest by early semioticians to accurately organise their field in the institutions, and secondly, how this treatment, as a meta-field, thwarted its aspirations to be considered as a fully-fledged discipline. Thirdly, I engage in a current discussion (Parra, 2020) in semiotics that questions how semiotics has favoured applied approaches to the production of meaning.
No ano de 1894, uma carta de Saussure a Meillet
Authors: Altman Cristina
Published: January 2024

A pretexto de contextualizar a propalada carta de Ferdinand de Saussure (1857-1913) a Antoine Meillet (1866-1936), em 1894, o texto revisita alguns temas da linguística saussuriana das últimas décadas do século XIX: a Linguística Indo-Europeia; o sistema vocálico do indo-europeu primitivo; os coeficientes sonânticos; a acentuação e a entonação do lituano; a insatisfação com o estado da arte linguística e a proposição, ainda incipiente, de uma Linguística Geral que fornecesse instrumentos conceptuais para a análise, descrição e explicação do milharal de dados que o século XX herdou dos seus antecessores. A conclusão aponta para o interesse em se rever os critérios de periodização das historiografias linguísticas tradicionais que, em geral, apontam o Curso de Linguística Geral (Saussure, 1916), como o grande shibboleth entre a Linguística Histórico-Comparativa e a Linguística Sincrônica ‘moderna’.
A comunicação organizacional por uma perspectiva interseccional. Uma proposta de diálogo com os feminismos
Authors: Molari Beatriz
Published: January 2024

O enfoque crítico da comunicação organizacional investiga como os processos de comunicação são articulados nas relações de poder estabelecidas na organização. Esse aspecto se aproxima da interseccionalidade, que enfatiza a interação de dois ou mais eixos de dominação na constituição das posições sociais. Com base nisso, este artigo visa responder teoricamente como a perspectiva interseccional pode contribuir para os estudos de comunicação organizacional crítica, considerando as desigualdades sociais presentes na sociedade brasileira.
Ptpn23 Controls Cardiac T-Tubule Patterning by Promoting the Assembly of Dystrophin-Glycoprotein Complex
Authors: Xu Chen , Zhang Ge , Wang Xinjian , Huang Xiaozhi , Zhang Jiayin , Han Shuxian , Wang Jinxi , Hall Duane D. , Xu Ruoqing , He Feng , Chang Xing , Wang Fudi , Xie Wenjun , Wu Zhichao , Song Long-Sheng , Han Peidong
Published: January 2024

BACKGROUND:

Cardiac transverse tubules (T-tubules) are anchored to sarcomeric Z-discs by costameres to establish a regular spaced pattern. One of the major components of costameres is the dystrophin-glycoprotein complex (DGC). Nevertheless, how the assembly of the DGC coordinates with the formation and maintenance of T-tubules under physiological and pathological conditions remains unclear.

METHODS:

Given the known role of Ptpn23 (protein tyrosine phosphatase, nonreceptor type 23) in regulating membrane deformation, its expression in patients with dilated cardiomyopathy was determined. Taking advantage of Cre/Loxp, CRISPR/Cas9, and adeno-associated virus 9 (AAV9)–mediated in vivo gene editing, we generated cardiomyocyte-specific
Ptpn23
and
Actn2
(α-actinin-2, a major component of Z-discs) knockout mice. We also perturbed the DGC by using dystrophin global knockout mice (
Dmd
E4*
). MM 4-64 and Di-8-ANEPPS staining, Cav3 immunofluorescence, and transmission electron microscopy were performed to determine T-tubule structure in isolated cells and intact hearts. In addition, the assembly of the DGC with
Ptpn23
and dystrophin loss of function was determined by glycerol-gradient fractionation and SDS-PAGE analysis.

RESULTS:

The expression level of Ptpn23 was reduced in failing hearts from dilated cardiomyopathy patients and mice. Genetic deletion of
Ptpn23
resulted in disorganized T-tubules with enlarged diameters and progressive dilated cardiomyopathy without affecting sarcomere organization. AAV9-mediated mosaic somatic mutagenesis further indicated a cell-autonomous role of
Ptpn23
in regulating T-tubule formation. Genetic and biochemical analyses showed that Ptpn23 was essential for the integrity of costameres, which anchor the T-tubule membrane to Z-discs, through interactions with α-actinin and dystrophin. Deletion of α-actinin altered the subcellular localization of Ptpn23 and DGCs. In addition, genetic inactivation of dystrophin caused similar T-tubule defects to
Ptpn23
loss-of-function without affecting Ptpn23 localization at Z-discs. Last, inducible
Ptpn23
knockout at 1 month of age showed Ptpn23 is also required for the maintenance of T-tubules in adult cardiomyocytes.

CONCLUSIONS:

Ptpn23 is essential for cardiac T-tubule formation and maintenance along Z-discs. During postnatal heart development, Ptpn23 interacts with sarcomeric α-actinin and coordinates the assembly of the DGC at costameres to sculpt T-tubule spatial patterning and morphology.
Impact of Down Syndrome on Survival Among Patients With Congenital Heart Disease
Authors: Engsner Stella , Giang Kok Wai , Dellborg Mikael , Fedchenko Maria , Eriksson Peter , Mandalenakis Zacharias
Published: January 2024

Background

Increasing survival among patients with congenital heart disease (CHD) has recently been reported. However, the impact of Down syndrome (DS) in patients with CHD is still debated. We aimed to estimate survival in patients with CHD with versus without DS compared with matched controls from the general population without CHD or DS.

Methods and Results

We linked data from Swedish health registries to identify patients with CHD born between 1970 and 2017. Data from the Total Population Register were used to match each patient with CHD by sex and birth year with 8 controls without CHD or DS. A Cox proportional regression model was used to estimate mortality risk, and Kaplan–Meier curves were analyzed for the survival analysis. We identified 3285 patients with CHD‐DS, 64 529 patients with CHD without DS, and 26 128 matched controls. The mortality risk was 25.1 times higher (95% CI, 21.3–29.5) in patients with CHD‐DS versus controls. The mortality rate was 2 times higher (95% CI, 1.94–2.31) for patients with CHD with versus without DS. Lower mortality was found during the second versus first birth periods in patients with CHD‐DS compared with controls; hazard ratio: 46.8 (95% CI, 29.5–74.0) and 17.7 (95% CI, 12.8–24.42) in those born between 1970 and 1989 versus 1990 and 2017, respectively.

Conclusions

In this retrospective cohort study, the mortality risk among patients with CHD‐DS was 25 times higher compared with matched controls and 2 times higher compared with patients with CHD without DS. Survival was higher in patients with CHD‐DS born after versus before 1990, coinciding with the modern era of congenital heart care.
The Impact of Large-Scale Environments and a Southwest Vortex on Heavy Rainfall in Southern Taiwan in Late May 2020
Authors: Chien Fang-Ching , Chiu Yen-Chao
Published: January 2024

This paper investigates the impact of the environmental conditions during the first half of the 2020 mei-yu season (Y20) and the southwest vortex (SWV), as well as their interaction, on heavy precipitation in southern Taiwan during late May 2020, based on a quantitative approach through ensemble simulations. The control experiment successfully replicates observed heavy precipitation in southern and central Taiwan and reveals a positive spatial correlation between precipitation occurrence probabilities and mean accumulated precipitation, emphasizing continuous rainfall accumulation over intermittent extreme events. Comparative analyses with sensitivity experiments elucidate that the Y20, featuring an extended western North Pacific subtropical high, intensify pressure gradients and southwesterly flow near Taiwan, favoring precipitation in windward regions but hindering it in the east. The SWV creates a moist and vortical environment near Taiwan, amplifying moisture supply and westerly winds, promoting precipitation in southern Taiwan, and enhancing frontal activity. The interaction between the SWV and the Y20, though limited in its impact on providing favorable wind and moisture conditions for precipitation southwest of Taiwan, significantly contributes to precipitation in southern Taiwan. The reason is that although the SWV primarily enhances moisture and the Y20 predominantly boost southwesterly flow, creating favorable conditions for rainfall, substantial precipitation occurs only when both factors converge in a nonlinear interaction. The interaction increases frontal activity over the Taiwan Strait and influences the movement and strength of the SWV, enhancing southwesterly flow and moisture flux in southwestern Taiwan.
Right Colectomy for an Inflammatory Mass in the Cecum Later Found to Be Tuberculosis
Authors: Nawras Mohamad , Bosio Raul , Sipe Eilynn , Klein Peter , Pannell Stephanie M.
Published: January 2024

Gastrointestinal tuberculosis (TB) is a rare manifestation of extra-pulmonary TB that is known to mimic many different gastrointestinal diseases. We present a case of an 85-year-old male patient with delayed diagnosis of gastrointestinal TB who underwent colonic resection for a cecal mass that was initially suspected to be malignant. Acid-fast staining of the surgical specimen later revealed acid-fast bacilli and multiple lymph nodes with necrotizing granulomas. The purpose of this study is to stress the importance of including gastrointestinal TB as a differential diagnosis for patients with suspected colorectal malignancy, especially when initial biopsy results do not reveal malignant features.
Utilization and Outcomes of Roux-en-Y Gastric Bypass Surgery Following the Affordable Care Act in the United States
Authors: Weldeslase Terhas A. , Akinyemi Oluwasegun A. , Keeling Darien J. , Enchill Kobina A. , Cornwell Edward E. , Fullum Terrence M.
Published: January 2024

Background

The passage of the Affordable Care Act (ACA) in 2010 marked a pivotal moment in American health care policy, significantly expanding access to health care services. This study aims to explore the relationship between the ACA and the utilization and outcomes of Roux-en-Y Gastric Bypass (RYGB) surgery.

Methods

Using data from the National Inpatient Sample (NIS) Database, this retrospective study compares the pre-ACA period (2007-2009) with the post-ACA period (2017-2019), encompassing patients who had RYGB. Multivariable logistic analysis was done accounting for patient’s characteristics, comorbidities, and hospital type.

Results

In the combined periods, there were 158 186 RYGB procedures performed, with 30.0% transpiring in pre-ACA and 70.0% in the post-ACA. Post-ACA, the proportion of uninsured patients decreased from 4.8% to 3.6% ( P < .05), while Black patients increased from 12.5% to 18.5% ( P < .05). Medicaid-insured patients increased from 6.8% to 18.1% ( P < .05), and patients in the poorest income quartile increased from 20% to 26% ( P < .05). Patients in the post-ACA period were less likely to have longer hospital stays (OR = .16: 95% CI .16-.17, P < .01), in-hospital mortality (OR = .29: 95% CI .18-.46, P < .01), surgical site infection (OR = .25: 95% CI .21-.29, P < .01), postop hemorrhage (OR = .24: 95% CI .21-.28, P < .01), and anastomotic leak (OR = .14: 95% CI .10-.18, P < .01) than those in the pre-ACA period.

Discussion

Following the implementation of the ACA, utilization of bariatric surgery significantly increased, especially among Black patients, Medicaid beneficiaries, and low-income patients. Moreover, despite the inclusion of more high-risk surgical patients in the post-ACA period, there were better outcomes after surgery.
Impact of COVID-19 Pandemic Surge on Surgical Outcomes: A Retrospective Study
Authors: Yoshida Takuto , Chude-Sokei Rosemary , Araji Tarek , Adra Souheil
Published: January 2024

Background

The COVID-19 pandemic posed significant challenges to healthcare systems worldwide, including surgical care. While many studies examined the effect of the pandemic on different patient outcomes, there are none to date examining the impact of the pandemic surge on surgical outcomes. Our aim is to evaluate the impact of the COVID-19 surges on surgical outcomes using data from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database.

Methods

A single-center retrospective analysis of 7436 patients who underwent surgery between February 2020 and December 2022 was conducted. Patients were divided into those who underwent surgery during the surge of the pandemic (n = 1217) or outside that period (n = 6219). Primary outcomes were 30-day mortality and morbidity. Secondary outcomes included 30-day mortality, operation time, transfusion, reoperation, and specific postoperative complications. Multivariable logistic regression was used in our analysis. All analyses were conducted using the software “R” version 4.2.1. Statistical significance was set at α = .05 level.

Results

After adjusting for confounders, we found no significant difference in 30-day mortality and morbidity (OR: 1.06, 95% CI: .89-1.226, P = .5173) or 30-day mortality only (OR: 1.39, 95% CI: .788-2.14, P = .1364) between the two groups. No significant differences were observed in secondary outcomes. Sensitivity analyses yielded similar results to the multivariable logistic regression.

Conclusion

We found no evidence of increased 30-day mortality and morbidity in patients undergoing surgery during the COVID-19 surges compared to those undergoing surgery outside that period. Our results suggest that surgical care was maintained despite the challenges of the pandemic surges.
Factors Affecting Workers’ Mental Stress in Handover Activities During Human–Robot Collaboration
Authors: Lu Lu , Xie Ziyang , Wang Hanwen , Su Bingyi , Jung Sehee , Xu Xu
Published: January 2024

Objective

This study investigated the effects of different approach directions, movement speeds, and trajectories of a co-robot’s end-effector on workers’ mental stress during handover tasks.

Background

Human–robot collaboration (HRC) is gaining attention in industry and academia. Understanding robot-related factors causing mental stress is crucial for designing collaborative tasks that minimize workers’ stress.

Methods

Mental stress in HRC tasks was measured subjectively through self-reports and objectively through galvanic skin response (GSR) and electromyography (EMG). Robot-related factors including approach direction, movement speed, and trajectory were analyzed.

Results

Movement speed and approach direction had significant effects on subjective ratings, EMG, and GSR. High-speed and approaching from one side consistently resulted in higher fear, lower comfort, and predictability, as well as increased EMG and GSR signals, indicating higher mental stress. Movement trajectory affected GSR, with the sudden stop condition eliciting a stronger response compared to the constrained trajectory. Interaction effects between speed and approach direction were observed for “surprise” and “predictability” subjective ratings. At high speed, approach direction did not significantly differ, but at low speeds, approaching from the side was found to be more surprising and unpredictable compared to approaching from the front.

Conclusion

The mental stress of workers during HRC is lower when the robot’s end effector (1) approaches a worker within the worker’s field of view, (2) approaches at a lower speed, or (3) follows a constrained trajectory.

Application

The outcome of this study can serve as a guide to design HRC tasks with a low level of workers’ mental stress.
The effect of cellulose-derived binder on properties and performance of PM steels
Authors: Lyck Christian , Valler Peter , Kjeldsteen Peter , Tiedje Niels Skat
Published: January 2024

A room-temperature extrusion technique, originally developed for the extrusion of ceramic powders, has been adapted to the extrusion of metal powders. The extrusion technology relies on cellulose-derived binders, which in traditional ceramic practices are burned off during sintering in air. In this work, the influence of hydrogen-debinding on density, carbon and oxygen levels is studied by comparing the effects of hydrogen debinding with the effects of air-debinding in as-debound and as-sintered samples. The study found debinding in hydrogen to result in significant levels of residual carbon, which promote austenite at the sintering temperature, and reduce densification. Debinding in air was effective, resulting in very low carbon concentrations and densification of up to 97 vol.-%, but also a considerable amount of oxides, which were not completely reduced during hydrogen sintering.