bluuebunny/crossref_metadata_2025 huggingface dataset:
Guideline-Optimised Treatment in Heart Failure—Do Higher Doses Reduce Systemic Inflammation More Significantly?
Authors: Arvunescu Alexandru Mircea , Ionescu Ruxandra Florentina , Dumitrescu Silviu Ionel , Zaharia Ondin , Nanea Tiberiu Ioan
Published: May 2024

Background: Chronic inflammation is a constant phenomenon which accompanies the heart failure pathophysiology. In all phenotypes of heart failure, irrespective of the ejection fraction, there is a permanent low-grade activation and synthesis of proinflammatory cytokines. Many classes of anti-remodelling medication used in the treatment of chronic heart failure have been postulated to have an anti-inflammatory effect. Methods: This retrospective study enrolled 220 patients and focused on evaluating the effect of the most used active substances from these classes in reducing the level of inflammatory biomarkers (C reactive protein, erythrocyte sedimentation rate and fibrinogen) after initiation or up-titration. Our research is evaluating if this anti-inflammatory effect intensifies while raising the dose. The evaluation was performed at two visits with an interval between them of 6 months. Results: From the beta-blockers class, carvedilol showed a reduction in erythrocyte sedimentation rate (ESR), in low (6.25 mg, bi daily) and medium (12.5 mg, bi daily) doses. At the same time, sacubitril/valsartan showed a reduction in CRP levels. This effect was obtained only in the medium (49/51 mg, bi daily) and high (97/103 mg, bi daily) doses, with the maximum reduction being observed in the high dose. Conclusions: From the classes of medication evaluated, the study showed a significant reduction in ESR levels in the low and medium doses of carvedilol and a reduction in CRP values in the cases of medium and high doses of ARNI.
Clinical Outcomes of Transepithelial Photorefractive Keratectomy Performed with Smart Pulse Technology for the Correction of Moderate to High Myopia
Authors: Ho Tony
Published: May 2024

Purpose: To evaluate the safety and efficacy of the transepithelial photorefractive keratectomy (TransPRK) performed using smart pulse technology (SPT) in myopic eyes with refractive error ranging from −5.25 D to −9.75 D. Methods: This retrospective study evaluated the outcomes of SPT-assisted TransPRK in 150 eyes performed using a 1050 Hz AMARIS excimer laser. Results: At 6 months postoperative, 98% of eyes achieved uncorrected distance visual acuity (UDVA) of 20/25 or better, and postoperative UDVA within one line of preoperative corrected distance visual acuity (CDVA). No eyes lost any line of CDVA. Residual spherical equivalent refraction and cylinder within ±0.50 D of intended correction were achieved in 72% and 67% of eyes, respectively. Ninety-seven percent of eyes reported no halos and glare. Conclusions: TransPRK using a 1050 Hz excimer laser with SPT showed excellent predictability, safety, and efficacy for moderate to high myopia correction.
Partial Deployment to Save Space for Vessel Cannulation When Treating Complex Aortic Aneurysms with Narrow Paravisceral Lumen Is Also Feasible Using Inner-Branched Pre-Cannulated Endografts
Authors: Simonte Gioele , Gatta Emanuele , Vento Vincenzo , Parlani Gianbattista , Simonte Rachele , Montecchiani Luca , Isernia Giacomo
Published: May 2024

Introduction: The aim of this paper is to propose a sequential deployment technique for the E-nside off-the-shelf endograft that could potentially enhance target visceral vessel (TVV) cannulation and overstenting in narrow aortic anatomies. Methods: All data regarding patients consecutively treated in two aortic centers with the E-nside graft employing the partial deployment technique were included in the study cohort and analyzed. To execute the procedure with partial endograft deployment, the device should be prepared before insertion by advancing, under fluoroscopy, all four dedicated 400 cm long 0.018″ non-hydrophilic guidewires until their proximal ends reach the cranial graft’s edge. Anticipating this guidewire placement prevents the inability to do so once the endograft is partially released, avoiding potentially increased friction inside the constricted pre-loaded microchannels. The endograft is then advanced and deployed in the standard fashion, stopping just after the inner branch outlets are fully expanded. Tip capture is released, and the proximal end of the device is opened. Visceral vessel bridging is completed from an upper access in the desired sequence, and the graft is fully released after revascularizing one or more arteries. Preventing the distal edge of the graft from fully expanding improves visceral vessel cannulation and bridging component advancement, especially when dealing with restricted lumina. Results: A total of 26 patients were treated during the period December 2019–March 2024 with the described approach. Procedure was performed in urgent settings in 14/26 cases. The available lumen was narrower than 24 mm at the origin of at least one target vessel in 11 out of 26 cases performed (42.3%). Technical success was obtained in 24 out of 26 cases (92.3%), with failures being due to TVVs loss. No intraoperative death or surgical conversion was recorded, and no early reintervention was needed in the perioperative period. Clinical success at 30 days was therefore 80.7%. Conclusions: The described technique could be considered effective in saving space outside of the graft, allowing for safe navigation and target vessel cannulation in narrow visceral aortas, similar to what has already been reported for outer-branched endografts.
Can We Improve the Technique of Pelvic Floor Muscle Exercises in Postmenopausal Women Using a Single Electromyography Biofeedback Session? An Experimental Study
Authors: Piernicka Magdalena , Ossowski Zbigniew , Kortas Jakub , Bojar Damian , Labun Justyna , Szumilewicz Anna
Published: May 2024

Background: The aim of this study was to assess the effect of a single session of EMG biofeedback in a group of postmenopausal women on improving technique in pelvic floor muscle (PFM) contractions (exercises). Methods: Sixty-two women aged 60 to 85 years (69 ± 4; mean ± SD) participated in the study. We assessed the technique of PFM exercises via surface electromyography (EMG) using a vaginal probe. A single assessment sequence consisted of 11 exercises involving the conscious contraction of the PFM, during which the order of activation for selected muscles was determined. We then awarded scores for exercise technique on a scale from 0 to 4, where 4 represented the best technique and 0 represented no activation of PFMs. In the second assessment, we used a biofeedback method to teach PFM exercise technique. Results: In total, 32% (n = 20) of the participants were unable to correctly perform the first PFM contraction, scoring 0.9 ± 0.79. After a single EMG biofeedback session, these women received 1.7 ± 1.08 scores (p = 0.003). In the tenth exercise, there was also a statistically significant improvement between the first (baseline) and second assessment (1.7 ± 1.34 and 2.15 ± 1.09, respectively; p = 0.037). For the remaining exercises, the results were not statistically significant, but we observed a positive trend of change. Conclusions: The use of a single EMG biofeedback session is an effective method of improving technique in PFM exercises in a group of women who initially performed them incorrectly.
Management of Cardiovascular Complications in Antiphospholipid Syndrome: A Narrative Review with a Focus on Older Adults
Authors: Bernardi Marco , Spadafora Luigi , Andaloro Silvia , Piscitelli Alessandra , Fornaci Giovanni , Intonti Chiara , Fratta Alberto Emanuele , Hsu Chieh-En , Kaziròd-Wolski Karol , Metsovitis Theodora , Biondi-Zoccai Giuseppe , Sabouret Pierre , Marzetti Emanuele , Cacciatore Stefano
Published: May 2024

Antiphospholipid syndrome (APS), also known as Hughes syndrome, is an acquired autoimmune and procoagulant condition that predisposes individuals to recurrent thrombotic events and obstetric complications. Central is the role of three types of antiphospholipid antibodies that target phospholipid-binding proteins: lupus anticoagulant (LAC), anti-β2-glycoprotein I (β2-GPI-Ab), and anti-cardiolipin (aCL). Together with clinical data, these antibodies are the diagnostic standard. However, the diagnosis of APS in older adults may be challenging and, in the diagnostic workup of thromboembolic complications, it is an underestimated etiology. The therapeutic management of APS requires distinguishing two groups with differential risks of thromboembolic complications. The standard therapy is based on low-dose aspirin in the low-risk group and vitamin K antagonists in the high-risk group. The value of direct oral anticoagulants is currently controversial. The potential role of monoclonal antibodies is investigated. For example, rituximab is currently recommended in catastrophic antiphospholipid antibody syndrome. Research is ongoing on other monoclonal antibodies, such as daratumumab and obinutuzumab. This narrative review illustrates the pathophysiological mechanisms of APS, with a particular emphasis on cardiovascular complications and their impact in older adults. This article also highlights advancements in the diagnosis, risk stratification, and management of APS.
Investigation of Thermomechanical and Dielectric Properties of PLA-CA 3D-Printed Biobased Materials
Authors: Lecoublet Morgan , Ragoubi Mohamed , Leblanc Nathalie , Koubaa Ahmed
Published: May 2024

Renewable dielectric materials have attracted the attention of industries and stakeholders, but such materials possess limited properties. This research focused on studying polylactic acid (PLA)/cellulose acetate (CA) blends produced by 3D printing to facilitate their integration into the electrical insulation field. The dielectric findings showed that a blend containing 40% of CA by weight had a dielectric constant of 2.9 and an electrical conductivity of 1.26 × 10−11 S·cm−1 at 100 Hz and 20 °C while exhibiting better mechanical rigidity in the rubbery state than neat PLA. In addition, it was possible to increase the electrical insulating effect by reducing the infill ratio at the cost of reduced mechanical properties. The differential scanning calorimetry, broadband dielectric spectroscopy, and dynamic mechanical analysis results showed that the PLA plasticizer reduced the energy required for PLA relaxations. These preliminary results demonstrated the benefits of using a combination of PLA, CA, and 3D printing for electrical insulation applications.
Microstructure Evolution of Polyacrylonitrile-Based Fibers during Thermal Pre-Oxidation
Authors: Sun Yue , Wang Yanxiang , Wang Lanzhong , Wang Yongbo , Ding Bohan , Guo Jinghe , Dai Shichao , Wang Yuxia
Published: May 2024

In this work, pre-oxidized polyacrylonitrile fibers are treated with ultrasonic etching and solution etching to produce ultra-thin sections. The evolution of the fibers’ microstructure in the pre-oxidation process is observed, and the transformation model of the microstructure of the pre-oxidized fibers is proposed. Scanning electron microscopy and high-resolution transmission electron microscopy were used to observe the microstructure changes of the fibers. Fourier transform infrared spectroscopy and X-ray diffraction were used to observe the chemical structure transformation and crystallization degree of the fibers in the pre-oxidation process. The results revealed that pre-oxidized fibers exhibited a smooth surface, while their interior consisted of fibrils. The longitudinal microfibrils were connected by the transverse microfibrils and amorphous regions. The fracture morphology of the fibers shifted from ductile to brittle, and the cross-section gradually became smoother. The linear molecular chain of PAN transformed into a ring structure as pre-oxidation progressed, subsequently leading to the cross-linking of this ring structure into an orderly trapezoidal configuration. The connection between the fibrils was enhanced, and the fiber structure became more compact and stable.
Fabrication of a Triple-Layer Bionic Vascular Scaffold via Hybrid Electrospinning
Authors: Ma Feier , Huang Xiaojing , Wang Yan
Published: May 2024

Tissue engineering aims to develop bionic scaffolds as alternatives to autologous vascular grafts due to their limited availability. This study introduces a novel wet-electrospinning fabrication technique to create small-diameter, uniformly aligned tubular scaffolds. By combining this innovative method with conventional electrospinning, a bionic tri-layer scaffold that mimics the zonal structure of vascular tissues is produced. The inner and outer layers consist of PCL/Gelatin and PCL/PLGA fibers, respectively, while the middle layer is crafted using PCL through Wet Vertical Magnetic Rod Electrospinning (WVMRE). The scaffold’s morphology is analyzed using Scanning Electron Microscopy (SEM) to confirm its bionic structure. The mechanical properties, degradation profile, wettability, and biocompatibility of the scaffold are also characterized. To enhance hemocompatibility, the scaffold is crosslinked with heparin. The results demonstrate sufficient mechanical properties, good wettability of the inner layer, proper degradability of the inner and middle layers, and overall good biocompatibility. In conclusion, this study successfully develops a small-diameter tri-layer tubular scaffold that meets the required specifications.
On the Spanwise Periodicity within the Gap between Two Different-Sized Tandem Circular Cylinders at Re = 3900
Authors: Zhang Di , Liang Dongfang , Deng Jun , Liu Yakun , Xie Jialiang
Published: May 2024

Although the spanwise periodicity within the gap between two tandem circular cylinders has been observed by some researchers, there is a lack of systematic research on the properties of this periodicity. For the spanwise periodicity within the gap, this study aims to ascertain its characteristics, its influences on the flow field, and its variation trend with increasing spacing ratio. By numerically simulating the flow around two tandem circular cylinders with a diameter ratio of d/D = 0.6 and seventeen spacing ratios (L/D = 1.00~6.00) at Re = 3900, this study shows four flow regimes: Reattachment Flow (L/D = 1.00~3.15), Bi-stable Flow (L/D = 3.24), Intermittent Lock-in Co-shedding (L/D = 3.30~3.50), and Subharmonic Lock-in Co-shedding (L/D = 4.00~6.00). Further, depending on the spanwise periodicity length of the time-averaged flow structures (i.e., Pz) within the gap, Reattachment Flow is, for the first time, subdivided into three new sub-flow regimes: Small-scale Periodic Reattachment (L/D = 1.00~1.50, Pz/D = (0, 4]), Large-scale Periodic Reattachment (L/D = 2.00~2.25, Pz/D > 4) and Non-periodic Reattachment (L/D = 2.50~3.15, no spanwise periodicity). The formation mechanisms are elaborated by analyzing the combined effect of both the L/D value and the spanwise-averaged time-averaged reattachment angle of the downstream cylinder. Moreover, this study proves that the newly defined Small-scale Periodic Reattachment and Large-scale Periodic Reattachment are responsible for the pronounced asymmetry of the flow along the transverse direction within the gap. In addition, detailed flow properties and statistical parameters are provided for each flow regime, such as velocity, vorticity, force coefficient, separation/reattachment angle, Strouhal number, and Q-criterion.
Numerical Investigation on a High-Speed Transom Stern Ship Advancing in Shallow Water
Authors: Zhao Zhi-Lei , Yang Bai-Cheng , Zhou Zhi-Rong
Published: May 2024

A high-speed advancing ship will cause significant squats in shallow water, which could increase the risk of grounding. To this end, a program based on the Rankine higher-order boundary element method (HOBEM) is developed to investigate a high-speed displacement ship with a transom stern moving in shallow water. The nonlinear free surface condition is satisfied by adopting an iterative algorithm on the real free surface. The transom condition is considered by implementing a modified transom condition. Computations of wave-making resistance, sinkage and trim in deep water are first performed, and satisfactory agreement is achieved by comparing with the experimental results; the simulations are then extended to the shallow water case. It indicates that the present method can provide a suitable balance of practicability and robustness, which can be considered as an efficient tool for the guidance in ship design stage.
Exploring the Response of Ecosystem Services to Socioecological Factors in the Yangtze River Economic Belt, China
Authors: Zhang Zhiming , Fang Fengman , Yao Youru , Ji Qing , Cheng Xiaojing
Published: May 2024

Understanding the response of the mechanisms driving ecosystem services (ESs) to socioecological factors is imperative for regional sustainable ecosystem management. However, previous studies of the mechanisms driving ESs have focused more on the degree and direction (positive and negative) of effects on ES supply or the supply–demand balance, while their nonlinear response processes have not been fully considered. In this study, a theoretical framework was developed through integrating land use/land cover data and supply and demand matrices with random forest models to assess response processes, including the relative importance and marginal effects, of essential factors that drive ES demand, supply, and supply–demand balance. Using the Yangtze River Economic Belt (YREB) as an example, our results indicated that the ES deficit regions (332 of 1070 counties or 14.45% of the area) of the YREB were located mainly in the three national urban agglomerations. Moreover, this study indicated that natural environmental factors (such as slope and precipitation) significantly influence the supply and supply–demand balance of ESs, while socioeconomic factors (such as cropland ratios and population density) profoundly influence the demand for ESs. However, cropland ratios were the most important drivers of ES supply, demand, and supply–demand balance in the YREB. Moreover, three types of response processes were identified in this study: logarithmic increase, logarithmic decrease, and volatility increase. Specific driving factors (e.g., proportion of cropland area, precipitation, population density, and slope) had significant threshold effects on the supply–demand balance of ESs. The turning points that can be extracted from these response processes should be recommended for ecosystem restoration projects to maintain regional sustainable ecosystem management.
How Does the Neighborhood Unit Inform Community Revitalization?
Authors: Banai Reza
Published: May 2024

Community revitalization is a complex, multifaceted process, studied conceptually and empirically in the vast multidisciplinary literature. Among the cited elements of community revitalization are housing; school, civic, and retail spaces; street networks; parks; and green spaces. However, the elements are commonly studied in isolation, not considering their interrelated qualities as all-of-a-piece of the community revitalization process. In this paper, we draw on the concept of the neighborhood unit that facilities a holistic approach to community revitalization. We show how the neighborhood unit is metamorphosed and thereby endured from the classic to the contemporary. We argue that the neighborhood unit informs, as well as being challenged by, community revitalization. Furthermore, inadequate attention is given to how urban revitalization challenges the efficacy of the neighborhood unit itself. The inner-city blight provides an impetus to look beyond the neighborhood to the metropolitan region as a whole. The neighborhood unit’s fundamental limitation is posed by its cellular autonomy, in favor of alternatives that connect the neighborhood to the metropolitan region’s jobs–housing–services–mobility opportunity holistically. Our literature review of the impactful elements of community revitalization is aided by AI (ChatGPT) as an expeditious search engine. It is found that the AI-aided search of the universal poses anew the significance of the particular—the site- and context-specific. We conclude with universal “performance dimensions” of Good City Form that are calibrated locally, reflecting the goodness of the city form, of which the neighborhood is a building block.
May the Force Be with You... Gesturality of the Barcelonians Associated with Mockery, Insult and Protection
Authors: Forment Mar , Illamola Cristina
Published: May 2024

The aim of the article is to inventory gestures related to mockery, insult, attracting good luck, or warding off bad luck that a group of informants from Barcelona have performed. The data come from the application of the survey from the Atlas de Gestos, whose task is to collect gestures from the Pan-Hispanic context to describe the gestural repertoire of each territory and conduct comparative studies. The results, interpreted based on social factors (gender, age, and level of instruction), confirm the wide range of gestures for different functions (10 for mockery, 11 for insult and attracting good luck, and 9 for warding off bad luck). Regarding differences based on social variables, the results allow for indicating trends, namely, while the most used gesture to express mockery is sticking out the tongue, young people prefer the gesture of pointing and laughing, and informants over 55 years old only prefer laughing. Concerning insults, the use of peineta is widespread, although differences in behavior between men and women are observed. As for attracting good luck, Barcelona informants opt for crossing fingers, although older generations use gestures with more religious connotations, such as clasping hands. Finally, to ward off bad luck, Barcelona locals mention the gesture of crossing made with the index fingers of each hand.
Racialized Sociolinguistic Processes in the Spanish Learning Journeys of Non-Latinxs in the U.S.
Authors: Exford Jazmine
Published: May 2024

Sociolinguistic frameworks of race have not been widely applied to non-Latinx Spanish learners in the United States. Consequently, there is limited insight into the impact of race on different learners’ use of Spanish in their communities, including the local or national raciolinguistic dynamics between Latinxs and non-Latinxs that inform these outcomes. This article examines ethnographic interviews of women recounting interactions and experiences of using Spanish in different U.S. contexts. In their accounts, I identify three racialized sociolinguistic processes central to their Spanish learning journeys, which I title racialized positionality, racialized embodiment, and indexical fields of racialization. These processes highlight, respectively, (1) the raciolinguistic dynamics enacted by Spanish language usage in the U.S. by non-Latinxs, (2) the sociolinguistic input a learner comes across as raciogendered subjects, and (3) the social meaning they ascribe to racialized terms and discourses in Spanish. As critical approaches to Spanish language learning and pedagogy continue to emerge, more research is warranted on these three processes to trace the impact of race on Spanish language learning and use.
Printing and Coating Techniques for Scalable Organic Photovoltaic Fabrication
Authors: Kirk Bradley P. , Bjuggren Jonas M. , Andersson Gunther G. , Dastoor Paul , Andersson Mats R.
Published: May 2024

Within recent years, there has been an increased interest towards organic photovoltaics (OPVs), especially with their significant device performance reaching beyond 19% since 2022. With these advances in the device performance of laboratory-scaled OPVs, there has also been more attention directed towards using printing and coating methods that are compatible with large-scale fabrication. Though large-area (>100 cm2) OPVs have reached an efficiency of 15%, this is still behind that of laboratory-scale OPVs. There also needs to be more focus on determining strategies for improving the lifetime of OPVs that are suitable for scalable manufacturing, as well as methods for reducing material and manufacturing costs. In this paper, we compare several printing and coating methods that are employed to fabricate OPVs, with the main focus towards the deposition of the active layer. This includes a comparison of performances at laboratory (<1 cm2), small (1–10 cm2), medium (10–100 cm2), and large (>100 cm2) active area fabrications, encompassing devices that use scalable printing and coating methods for only the active layer, as well as “fully printed/coated” devices. The article also compares the research focus of each of the printing and coating techniques and predicts the general direction that scalable and large-scale OPVs will head towards.
Green Synthesis of Iron Nanoparticles Using an Aqueous Extract of Strawberry (Fragaria × ananassa Duchesne) Leaf Waste
Authors: Góral-Kowalczyk Małgorzata , Grządka Elżbieta , Orzeł Jolanta , Góral Dariusz , Skrzypek Tomasz , Kobus Zbigniew , Nawrocka Agnieszka
Published: May 2024

In this study, we analysed the potential use of dried strawberry leaves and calyces for the production of nanoparticles using inorganic iron compounds. We used the following iron precursors FeCl3 × 6H2O, FeCl2 × 4H2O, Fe(NO3)3 × 9H2O, Fe2(SO4)3 × H2O, FeSO4 × 7H2O, FeCl3 anhydrous. It was discovered that the content of polyphenols and flavonoids in dried strawberries and their antioxidant activity in DPPH and FRAP were 346.81 µM TE/1 g and 331.71 µM TE/1 g, respectively, and were similar to these of green tea extracts. Microimages made using TEM techniques allowed for the isolation of a few nanoparticles with dimensions ranging from tens of nanometres to several micrometres. The value of the electrokinetic potential in all samples was negative and ranged from −21,300 mV to −11,183 mV. XRF analyses confirmed the presence of iron ranging from 0.13% to 0.92% in the samples with a concentration of 0.01 mol/dm3. FT-IR spectra analyses showed bands characteristic of nanoparticles. In calorimetric measurements, no increase in temperature was observed in any of the tests during exposure to the electromagnetic field. In summary, using the extract from dried strawberry leaves and calyxes as a reagent, we can obtain iron nanoparticles with sizes dependent on the concentration of the precursor.
Numerical Study on Mechanical Behavior and Electromechanical Properties of Solder-Jointed REBCO-Coated Conductors
Authors: Liao Tianfa , Wang Wenyuan , Chen Zhiming , Guan Mingzhi
Published: May 2024

As the second-generation high-temperature superconducting conductors, rare earth–barium–copper–oxide (REBCO) coated conductor (CC) tapes have good potential as high-field and high-energy superconductors. In superconducting applications, several joints are required for conjugating comparatively short REBCO CC tapes. Soldering lap joints are the simplest and most commonly applied REBCO CC joints. In addition to joint resistance, the mechanical behavior and electromechanical properties are also crucial for superconducting applications. In this paper, the electromechanical properties and mechanical behaviors of soldering lap joints at 77 K under a self-field were studied. The mechanical behavior was addressed by using a full three-dimensional multilayer elastic–plastic finite element model (FEM) with REBCO CC tape main layers and solder connecting layers. Then, the electromechanical properties were analyzed by using Gao’s strain-Ic degradation general model on the basis of the FEM results. Both the mechanical behavior and electromechanical properties were verified by experimental results. The effects of soldering lap conditions including lap length, soldering thickness and lap style on the electromechanical properties and mechanical behaviors were discussed. The results indicate that shorter overlap lengths and a thinner solder can reduce the premature degradation of Ic due to stress concentrations nearby the joint edges; moreover, the irreversible critical strain is significantly higher in the back-to-back joint approach compared to the widely used face-to-face joint approach.
Learning-Based Planner for Unknown Object Dexterous Manipulation Using ANFIS
Authors: Sheikhsamad Mohammad , Suárez Raúl , Rosell Jan
Published: May 2024

Dexterous manipulation of unknown objects performed by robots equipped with mechanical hands represents a critical challenge. The difficulties arise from the absence of a precise model of the manipulated objects, unpredictable environments, and limited sensing capabilities of the mechanical hands compared to human hands. This paper introduces a data-driven approach that provides a learning-based planner for dexterous manipulation employing an Adaptive Neuro-Fuzzy Inference System (ANFIS) fed by data obtained from an analytical manipulation planner. ANFIS captures the complex relationships between inputs and optimal manipulation parameters. Moreover, during a training phase, it is able to fine-tune itself on the basis of its experiences. The proposed planner enables a robot to interact with objects of various shapes, sizes, and material properties while providing an adaptive solution for increasing robotic dexterity. The planner is validated in a real-world environment, applying an Allegro anthropomorphic robotic hand. A link to a video of the experiment is provided in the paper.
Ulam Stability for Boundary Value Problems of Differential Equations—Main Misunderstandings and How to Avoid Them
Authors: Agarwal Ravi P. , Hristova Snezhana , O’Regan Donal
Published: May 2024

Ulam type stability is an important property studied for different types of differential equations. When this type of stability is applied to boundary value problems, there are some misunderstandings in the literature. In connection with this, initially, we give a brief overview of the basic ideas of the application of Ulam type stability to initial value problems. We provide several examples with simulations to illustrate the main points in the application. Then, we focus on some misunderstandings in the application of Ulam stability to boundary value problems. We suggest a new way to avoid these misunderstandings and how to keep the main idea of Ulam type stability when it is applied to boundary value problems of differential equations. We present one possible way to connect both the solutions of the given problem and the solutions of the corresponding inequality. In addition, we provide several examples with simulations to illustrate the ideas for boundary value problems and we also show the necessity of the new way of applying the Ulam type stability. To illustrate the theoretical application of the suggested idea to Ulam type stability, we consider a linear boundary value problem for nonlinear impulsive fractional differential equations with the Caputo fractional derivative with respect to another function and piecewise-constant variable order. We define the Ulam–Hyers stability and obtain sufficient conditions on a finite interval. As partial cases, integral presentations of the solutions of boundary value problems for various types of fractional differential equations are obtained and their Ulam type stability is studied.
Optimizing Variational Quantum Neural Networks Based on Collective Intelligence
Authors: Li Zitong , Xiao Tailong , Deng Xiaoyang , Zeng Guihua , Li Weimin
Published: May 2024

Quantum machine learning stands out as one of the most promising applications of quantum computing, widely believed to possess potential quantum advantages. In the era of noisy intermediate-scale quantum, the scale and quality of quantum computers are limited, and quantum algorithms based on fault-tolerant quantum computing paradigms cannot be experimentally verified in the short term. The variational quantum algorithm design paradigm can better adapt to the practical characteristics of noisy quantum hardware and is currently one of the most promising solutions. However, variational quantum algorithms, due to their highly entangled nature, encounter the phenomenon known as the “barren plateau” during the optimization and training processes, making effective optimization challenging. This paper addresses this challenging issue by researching a variational quantum neural network optimization method based on collective intelligence algorithms. The aim is to overcome optimization difficulties encountered by traditional methods such as gradient descent. We study two typical applications of using quantum neural networks: random 2D Hamiltonian ground state solving and quantum phase recognition. We find that the collective intelligence algorithm shows a better optimization compared to gradient descent. The solution accuracy of ground energy and phase classification is enhanced, and the optimization iterations are also reduced. We highlight that the collective intelligence algorithm has great potential in tackling the optimization of variational quantum algorithms.
A Composite Half-Normal-Pareto Distribution with Applications to Income and Expenditure Data
Authors: Olmos Neveka M. , Gómez-Déniz Emilio , Venegas Osvaldo , Gómez Héctor W.
Published: May 2024

The half-normal distribution is composited with the Pareto model to obtain a uni-parametric distribution with a heavy right tail, called the composite half-normal-Pareto distribution. This new distribution is useful for modeling positive data with atypical observations. We study the properties and the behavior of the right tail of this new distribution. We estimate the parameter using a method based on percentiles and the maximum likelihood method and assess the performance of the maximum likelihood estimator using Monte Carlo. We report three applications, one with simulated data and the others with income and expenditure data, in which the new distribution presents better performance than the Pareto distribution.
A Software Reliability Model Considering a Scale Parameter of the Uncertainty and a New Criterion
Authors: Song Kwang Yoon , Kim Youn Su , Pham Hoang , Chang In Hong
Published: May 2024

It is becoming increasingly common for software to operate in various environments. However, even if the software performs well in the test phase, uncertain operating environments may cause new software failures. Traditional proposed software reliability models under uncertain operating environments suffer from the problem of being well-suited to special cases due to the large number of assumptions involved. To improve these problems, this study proposes a new software reliability model that assumes an uncertain operating environment. The new software reliability model is a model that minimizes assumptions and minimizes the number of parameters that make up the model, so that the model can be applied to general situations better than the traditional proposed software reliability models. In addition, various criteria based on the difference between the predicted and estimated values have been used in the past to demonstrate the superiority of the software reliability models. Also, we propose a new multi-criteria decision method that can simultaneously consider multiple goodness-of-fit criteria. The multi-criteria decision method using ranking is useful for comprehensive evaluation because it does not rely on individual criteria alone by ranking and weighting multiple criteria for the model. Based on this, 21 existing models are compared with the proposed model using two datasets, and the proposed model is found to be superior for both datasets using 15 criteria and the multi-criteria decision method using ranking.
Evaluation of Antimicrobial Resistance in Clinical Isolates of Enterococcus spp. Obtained from Hospital Patients in Latvia
Authors: Labecka Linda , Ķibilds Juris , Cīrulis Aivars , Čeirāne Evelīna , Zeltiņa Indra , Reinis Aigars , Vilima Barba , Rudzīte Dace , Erts Renārs , Mauliņa Inga , Bandere Dace , Krūmiņa Angelika
Published: May 2024

Background and Objective: Enterococci are typically found in a healthy human gastrointestinal tract but can cause severe infections in immunocompromised patients. Such infections are treated with antibiotics. This study addresses the rising concern of antimicrobial resistance (AMR) in Enterococci, focusing on the prevalence of vancomycin-resistant enterococcus (VRE) strains. Materials and Methods: The pilot study involved 140 Enterococci isolates collected between 2021 and 2022 from two multidisciplinary hospitals (with and without local therapeutic drug monitoring protocol of vancomycin) in Latvia. Microbiological assays and whole genome sequencing were used. AMR gene prevalence with resistance profiles were determined and the genetic relationship and outbreak evaluation were made by applying core genome multi-locus sequence typing (cgMLST). Results: The acquired genes and mutations were responsible for resistance against 10 antimicrobial classes, including 25.0% of isolates expressing resistance to vancomycin, predominantly of the vanB type. Genetic diversity among E. faecalis and E. faecium isolates was observed and seven potential outbreak clusters were identified, three of them containing sequence types ST6, ST78 and ST80. The prevalence of vancomycin resistance was highest in the hospital without a therapeutic drug-monitoring protocol and in E. faecium. Notably, a case of linezolid resistance due to a mutation was documented. Conclusions: The study illustrates the concerning prevalence of multidrug-resistant Enterococci in Latvian hospitals, showcasing the rather widespread occurrence of vancomycin-resistant strains. This highlights the urgency of implementing efficient infection control mechanisms and the need for continuous VRE surveillance in Latvia to define the scope and pattern of the problem, influencing clinical decision making and planning further preventative measures.
Adherence, Disease Control, and Misconceptions Related to the Use of Inhalation Therapy in Patients with Obstructive Pulmonary Diseases: A Cross-Sectional Study
Authors: Živanović Dejan , Javorac Jovan , Savić Dejana , Mikić Andrijana , Jevtić Marija , Ilić Miroslav , Kolarov Violeta , Minaković Ivana , Kolarš Bela , Smuđa Mirjana , Mijatović Jovin Vesna
Published: May 2024

Background and Objectives: Inadequate treatment of asthma and chronic obstructive pulmonary disease (COPD) might have a negative impact on their progression. Inhalation therapy is the cornerstone of pharmacotherapy for these conditions. However, challenges such as low adherence, negative attitudes, and misconceptions about inhaled medications still persist, impeding effective disease management. This study aimed to evaluate adherence, ascertain the level of disease control in asthma and COPD, explore potential misconceptions surrounding inhalation therapy among patients with obstructive lung diseases and the general population in Vojvodina, and evaluate the reliability of newly developed questionnaires employed in the study. Materials and Methods: This cross-sectional study utilized a battery of questionnaires encompassing sociodemographic data, the Asthma Control Test (ACT), the COPD Assessment Test (CAT), along with two novel questionnaires—one for assessing adherence and another for analyzing attitudes toward inhalation therapy. Statistical analyses were conducted using SPSS software, version 25.0. Results: The average ACT score among patients with asthma was 17.31, while it was 19.09 for the CAT questionnaire among COPD patients. The composite score on the newly developed adherence assessment questionnaire was 2.27, exhibiting a reliability coefficient lower than recommended (α = 0.468). Significant statistical differences emerged among sample subgroups regarding attitudes and misconceptions toward inhalation therapy. The reliability coefficient for this questionnaire was deemed satisfactory (α = 0.767). Conclusions: Adherence rates were notably suboptimal in both subgroups of the studied population. The disease control levels were higher among asthma patients, while they exhibited less prevalent misconceptions regarding inhalation therapy compared to COPD patients and the healthy population.
Influence of Surface Chemical and Topographical Properties on Morphology, Wettability and Surface Coverage of Inkjet-Printed Graphene-Based Materials
Authors: Salaoru Iulia , Morris Dave , Ware Ecaterina , Nama Manjunatha Krishna
Published: May 2024

The inkjet printing of water-based graphene and graphene oxide inks on five substrates, two rigid (silicon and glass) and three flexible (cellulose, indium tin oxide-coated polyethylene terephthalate (ITO-PET) and ceramic coated paper (PEL paper)), is reported in this work. The physical properties of the inks, the chemical/topographical properties of selected substrates, and the inkjet printing (IJP) of the graphene-based materials, including the optimisation of the printing parameters together with the morphological characterisation of the printed layers, are investigated and described in this article. Furthermore, the impact of both the chemical and topographical properties of the substrates and the physical properties of graphene-based inks on the morphology, wettability and surface coverage of the inkjet-printed graphene patterns is studied and discussed in detail.
Multi-Scale Traditional and Non-Traditional Machining of Bulk Metallic Glasses (BMGs)—Review of Challenges, Recent Advances, and Future Directions
Authors: Jahan Muhammad P. , Niraula Aakash , Nafi Muhammad Abdun , Perveen Asma
Published: May 2024

Bulk metallic glasses (BMGs) are growing in popularity prominently due to their potential in micro-electromechanical systems (MEMSs) and aerospace applications. BMGs have unique mechanical properties, i.e., high strength, hardness, modulus of elasticity, and wear resistance, due to their disordered atomic structure. Due to their unique mechanical properties and amorphous structures, machining of BMGs remains a challenge. This paper aims to carry out a detailed literature review on various aspects of the machining of bulk metallic glasses using both conventional and non-conventional processes, including experimental approaches, modeling, statistical findings, challenges, and guidelines for machining this difficult-to-machine material. Conventional machining processes were found to be challenging for machining bulk metallic glasses due to their high hardness, brittleness, and tendency to convert their amorphous structure into a crystalline structure, especially at the machined surface and sub-surface. Although their high electrical conductivity makes them suitable for machining by non-conventional processes, they impose new challenges such as heat-affected zones and crystallization. Therefore, the successful machining of BMGs requires more in-depth analysis of cutting forces, tool wear, burr formation, surface finish, recast layers or heat-affected zones, crystallization, and mechanical property changes among different varieties of BMGs. This review paper provides guidelines emerging from in-depth analysis of previous studies, as well as offering directions for future research in the machining of BMGs.
Comparative Analysis of Laboratory-Based and Spectroscopic Methods Used to Estimate the Algal Density of Chlorella vulgaris
Authors: Fekete György , Sebők András , Klátyik Szandra , Varga Zsolt István , Grósz János , Czinkota Imre , Székács András , Aleksza László
Published: May 2024

Chlorella vulgaris is of great importance in numerous exploratory or industrial applications (e.g., medicals, food, and feed additives). Rapid quantification of algal biomass is crucial in photobioreactors for the optimization of nutrient management and the estimation of production. The main goal of this study is to provide a simple, rapid, and not-resource-intensive estimation method for determining the algal density of C. vulgaris according to the measured parameters using UV–Vis spectrophotometry. Comparative assessment measurements were conducted with seven different methods (e.g., filtration, evaporation, chlorophyll a extraction, and detection of optical density and fluorescence) to determine algal biomass. By analyzing the entire spectra of diluted algae samples, optimal wavelengths were determined through a stepwise series of linear regression analyses by a novel correlation scanning method, facilitating accurate parameter estimation. Nonlinear formulas for spectrometry-based estimation processes were derived for each parameter. As a result, a general formula for biomass concentration estimation was developed, with recommendations for suitable measuring devices based on algae concentration levels. New values for magnesium content and the average single-cell weight of C. vulgaris were established, in addition to the development of a rapid, semiautomated cell counting method, improving efficiency and accuracy in algae quantification for cultivation and biotechnology applications.
The Identification of the Mitochondrial DNA Polymerase γ (Mip1) of the Entomopathogenic Fungus Metarhizium brunneum
Authors: Varassas Stylianos P. , Amillis Sotiris , Pappas Katherine M. , Kouvelis Vassili N.
Published: May 2024

Replication of the mitochondrial (mt) genome in filamentous fungi is under-studied, and knowledge is based mainly on data from yeasts and higher eukaryotes. In this study, the mitochondrial DNA polymerase γ (Mip1) of the entomopathogenic fungus Metarhizium brunneum is characterized and analyzed with disruption experiments and its in silico interactions with key proteins implicated in mt gene transcription, i.e., mt RNA polymerase Rpo41 and mt transcription factor Mtf1. Disruption of mip1 gene and its partial expression influences cell growth, morphology, germination and stress tolerance. A putative in silico model of Mip1-Rpo41-Mtf1, which is known to be needed for the initiation of replication, was proposed and helped to identify potential amino acid residues of Mip1 that interact with the Rpo41-Mtf1 complex. Moreover, the reduced expression of mip1 indicates that Mip1 is not required for efficient transcription but only for replication. Functional differences between the M. brunneum Mip1 and its counterparts from Saccharomyces cerevisiae and higher eukaryotes are discussed.
Timing and Evolution of Gold Mineralization in the Maljavr Occurrence (NW Russia), NE Part of the Fennoscandian Shield
Authors: Kalinin Arkadii A. , Kudryashov Nickolay M. , Savchenko Yevgeny E.
Published: May 2024

Gold occurrence Maljavr is the first Archean conglomerate-hosted gold mineralization found in the Fennoscandian Shield. Gold-mineralized metasomatic rocks form a set of lenses within a 10 m thick linear zone, conformable to the bedding of host conglomerates. The lenses are up to 10 m long and up to 1 m thick and they clearly exhibit three alteration envelopes: the rock in the central part consists of garnet and quartz or garnet-only; biotite, garnet, and quartz make the intermediate biotite–garnet envelope; hornblende, hedenbergite, and quartz are the principal rock-forming minerals in the outer zone of the lenses. All metasomatic rocks contain sulfide mineralization up to 15–20 vol.% and up to 0.6 g/t Au. The main ore mineral is pyrrhotite, and the minor minerals are arsenopyrite, chalcopyrite, pentlandite, löllingite, and troilite. The age of zircon from biotite gneiss in the zone of alteration is 2664 ± 18 Ma, this is considered as the time of formation of lenses of metasomatic rocks. Biotite gneiss-conglomerate and metasomatic rocks were later intruded by tourmaline granite pegmatite 2508 ± 7 Ma. The injection of pegmatite caused re-crystallization of sulfides (mainly arsenopyrite and löllingite) and redistribution of gold. Visible gold in association with Bi minerals native bismuth, ehrigite, maldonite, bismuthinite, joseite-B, and hedleyite was found in inclusions in recrystallized arsenopyrite and löllingite. Au content in the rocks with recrystallized arsenopyrite and löllingite is >1 g/t, up to 30 g/t in hand samples. The 2508 Ma pegmatite is interpreted as synchronous with formation of gold mineralization in its present form. The linkage of gold mineralization with pegmatite and geochemical association Au-As-Se-Te-Bi in the mineralized rocks agree with characteristics of intrusion-related gold deposits worldwide. Biotite gneiss–metaconglomerate, hosting the mineralized altered rocks, was the probable primary source of arsenic and gold for mineralization.