bluuebunny/crossref_metadata_2025 huggingface dataset:
Problematizing Niceness
Authors: Reidel Michelle , Shannon-Baker Peggy , Toledo Courtney Alexander , Crawford Kathleen M. , Roberts Leslie D. , Huling Heather M. , Liston Delores D.
Published: November 2023

Culturally responsive teaching (CRT) advocates for “teaching to and through” cultural diversity to improve learning, build relationships, mediate classroom power imbalances, and challenge stereotypes and prejudices. Despite the plethora of research on CRT in the K-12 environment, there is a lack of research regarding how higher education faculty enact these practices. To address this disparity, an intentional learning community of teacher educators at a university in the US South conducted a self-study to identify areas in which they enact CRT. The authors used a qualitatively oriented, embedded mixed methods design using the culturally responsive teaching self-assessment tool (CRTA) and conversational interviews as data which were then descriptively and inductively analyzed, respectively. The analyses identified three major themes: (a) the impact of course delivery and content on the implementation of CRT, (b) the prevalence of niceness as an obstacle to CRT, and (c) the power of reflection for increased awareness and long-term change.
Proceedings of the 22nd Annual Sessions of the Perinatal Society of Sri Lanka
Authors: Editor-in-Chief .
Published: November 2023

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Human Intestinal Dendritic Cells Can Overcome Retinoic Acid Signaling to Generate Proinflammatory CD4 T Cells with Both Gut and Skin Homing Properties
Authors: Gordon Hannah , Wichmann Katherine , Lewis Amy , Sanders Theodore , Wildemann Martha , Hoti Inva , Hornsby Eve , Kok K Bel , Silver Andrew , Lindsay James O , Stagg Andrew J
Published: November 2023

Retinoic acid, produced by intestinal dendritic cells (DCs), promotes T cell trafficking to the intestinal mucosa by upregulating α4β7 integrin and inhibiting the generation of cutaneous leukocyte Ag (CLA) required for skin entry. In the present study, we report that activation of human naive CD4 T cells in an APC-free system generates cells expressing α4β7 alone; in contrast, activation by intestinal DCs that produce retinoic acid and induce high levels of α4β7 also results in CLA expression, generating CLA+α4β7+ “dual tropic” cells, with both gut and skin trafficking potential, that also express high levels of α4β1 integrin. DC generation of CLA+α4β7+ T cells is associated with upregulation of FUT7, a fucosyltransferase involved in CLA generation; requires cell contact; and is enhanced by IL-12/IL-23. The blood CD4+ T cell population contains CLA+α4β7+ cells, which are significantly enriched for cells capable of IFN-γ, IL-17, and TNF-α production compared with conventional CLA−α4β7+ cells. Dual tropic lymphocytes are increased in intestinal tissue from patients with Crohn’s disease, and single-cell RNA-sequencing analysis identifies a transcriptionally distinct cluster of FUT7-expressing cells present only in inflamed tissue; expression of genes associated with cell proliferation suggests that these cells are undergoing local activation. The expression of multiple trafficking molecules by CLA+α4β7+ T cells can enable their recruitment by alternative pathways to both skin and gut; they may contribute to both intestinal and cutaneous manifestations of inflammatory bowel disease.
Evaluation of Frameworks for MLOps and Microservices
Authors: Urias Igor , Rossi Rogério
Published: November 2023

Information Technology involves solutions for many kinds of industries and organizations, offering conditions for solving problems of different types and complexities. Artificial Intelligence, and more specifically applications that considers Machine Learning (ML) and Software Technology are part of these solutions for solving problems, including solutions for solving problems that involve smart cities approach. In order to present frameworks that deal with the operationalization of Machine Learning and Software technology, this article is based on the study and evaluation of frameworks that involve Machine Learning Operations (MLOps) and microservices. Specifically, three frameworks that integrate ML algorithms with microservices are evaluated based on a bibliographical review in scientific journals of relevance to the area. From an exploratory analysis of these frameworks, it was possible to highlight their main objectives, their benefits, and their ability to offer solutions that favor the large-scale use of Machine Learning algorithms in problem solving. The main results are highlighted in the article through a qualitative analysis that considers six evaluation criteria, such as: capacity for sharing resources, scope of use by users, and use in a cloud environment. The results achieved are satisfactory since the work allows, through a qualitative view of the evaluated frameworks, a perspective of how the integration of MLOps and microservices has been carried out, its benefits and possible results achieved through this integration.
Utilizing Blockchain Technology in Global Supply Chain Management: An Exploration of Scalable Information Systems
Authors: Syamsuddin  , Saharuddin  , Yusrizal  , Dharmawati Tuti , Fatmawati Endang
Published: November 2023

INTRODUCTION: Global supply chain management is a critical component in the increasingly complex and connected world of modern business. In the era of globalization, companies face pressure to increase efficiency, transparency, and security in their supply chains. Blockchain technology has emerged as a potential solution to address some of these challenges by enabling more decentralized, transparent, and efficient supply chain management. However, the use of this technology in global supply chain management also raises several issues related to regulation, law, and collaboration with third parties. OBJECTIVE: This research then aims to explore the potential of blockchain technology in global supply chain management and understand the regulatory framework needed to support the implementation of this technology. METHOD: This research was carried out using a qualitative approach. The data used in this research comes from various research results and previous studies that are relevant to the discussion. RESULTS: The results of this research then found that the use of blockchain technology in global supply chain management promises to increase transparency, efficiency, and security. Smart contracts enable the automation of business processes, reducing costs and increasing visibility of operations. Collaboration with third parties is an important strategy in increasing supply chain efficiency. Regulation, data security, and international harmonization remain challenges. CONCLUSION: Defining the legal status of smart contracts and protecting data is key. Effective collaboration with third parties requires good communication and a mature strategy. With a deep understanding of blockchain technology and proper regulation, companies can maximize their benefits to create an efficient, transparent, and reliable supply chain.
Compactifications of moduli of del Pezzo surfaces via line arrangement and K-stability
Authors: Zhao Junyan
Published: November 2023

In this paper, we study compactifications of the moduli of smooth del Pezzo surfaces using K-stability and the line arrangement. We construct K-moduli of log del Pezzo pairs with sum of lines as boundary divisors, and prove that for
$d=2,3,4$
, these K-moduli of pairs are isomorphic to the K-moduli spaces of del Pezzo surfaces. For
$d=1$
, we prove that they are different by exhibiting some walls.
Limiting the spillover of zoonotic pathogens from traditional food markets in developing countries and a new market design for risk-proofing
Authors: Ghatak Sandeep , Srinivas Kandhan , Milton Arockiasamy Arun Prince , Priya Govindarajan Bhuvana , Das Samir , Lindahl Johanna F.
Published: November 2023

Traditional food markets are age-old systems that primarily serve the food supply needs of society’s less affluent sectors, often operating with minimal infrastructure. These markets are prevalent in low and middle-income countries. However, their hygienic conditions are frequently suboptimal, potentially fostering the emergence and spread of presumptive zoonotic diseases. The recent emergence of zoonotic or potentially zoonotic diseases and their possible links to traditional food markets underscore the need for focused attention on this overlooked issue. The socioeconomic characteristics of traditional food markets reveal that despite the risk of zoonotic pathogen spread, these markets play a crucial role for large segments of the population. These individuals rely on such markets for their livelihood, food, and nutrition. Therefore, a comprehensive set of measures addressing various aspects of traditional food markets is necessary to manage and mitigate the risks of potential zoonotic disease emergence. In this article, we explore various facets of traditional food markets, paying special attention to the risks of zoonotic diseases that urgently require stakeholder attention. We also propose a new market design to prevent the risk of zoonotic spillover and advocate for the development of a Market Hygiene Index for these markets.
О существовании элемента с заданными уклонениями
от расширяющейся системы подпространств
Authors: Skvortsov Yury Aleksandrovich
Published: November 2023

Расширяется класс последовательностей уклонений, для которых задача
о существовании элемента банахова пространства с этими уклонениями
от системы вложенных подпространств решается положительно,
независимо от пространства и системы подпространств.
На основе этого результата сближаются константы слабой асимптотики
в теореме С. В. Конягина о существовании элемента,
уклонения которого асимптотически близки к заданным.
Библиография: 8 названий.
Geometrical description of equations related to the E8 affine Weyl group
Authors: Ramani Alfred , Grammaticos Basil , Tamizhmani Thamizharasi
Published: November 2023

We present a method for the construction of the trajectory of a discrete Painlev\'e equation associated with the affine Weyl group E$_8^{(1)}$ on the weight lattice of said group. The method is based on the geometrical description of the lattice and the construction of the fundamental Miura relation. To this end we introduce the relation between the nonlinear variables and the corresponding $\tau$ functions. Our approach is heuristic and makes use of some simple rules of thumb in order to derive the result. Once the latter is obtained, verifying that it does indeed correspond to the equation at hand is elementary. We apply our approach to the explicit construction of the trajectory of well-known, E$_8^{(1)}$ associated, discrete Painlev\'e equations derived in previous works of ours. For each of them we investigate the possibility of defining an evolution by periodically skipping up to four intermediate points in the trajectory and identifying the resulting equation to one previously obtained, whenever the latter exists.
ESTRATÉGIAS DE PERMANÊNCIA DE INDÍGENAS ESTUDANTES NA UNIVERSIDADE FEDERAL DO PARÁ: DESAFIOS E RESISTÊNCIA
Authors: San Martin Araya Ignacio Gabriel , Braga Fonseca Virginia
Published: November 2023

Este artigo aborda os processos de resistência dos estudantes indígenas na Universidade Federal do Pará (UFPA). Como abordagem usamos a etnografia multisituada e uma perspectiva biográfica, no qual examinamos como esses estudantes desenvolvem estratégias de permanência institucional. Enfrentando preconceito e desafios, eles se tornam agentes de mudança, usando o ensino superior como uma ferramenta de emancipação e preservação de suas culturas. Embora as ações afirmativas tenham avançado, a inclusão real desses estudantes ainda é um desafio. No entanto, suas lutas contribuem para a transformação da sociedade, promovendo a compreensão da diversidade cultural e o respeito pelos direitos indígenas e da floresta, apoiando assim, a preservação de seus territórios por meio das ferramentas proporcionadas por sua formação profissional.
DOS POVOS QUE ENCONTREI NOS "SOPÉS DA SERRA DO ESPINHAÇO”
Authors: Rocha Angélica de Santana , Rezende Ana Maria Nogueira
Published: November 2023

O texto apresentado traz, primeiramente, uma revisão de literatura identificando os Povos Caatingueiros localizados nas bases da Serra do Espinhaço, estes também presentes na obra Grande Sertão: Veredas, de João Guimarães Rosa, e, que contextualiza a história dos moradores da região com o bioma Caatinga.  E, vem ressaltar a necessidade dos esforços para preservação do patrimônio natural e, recentemente, o desejo de preservar o patrimônio histórico-cultural ao mesmo tempo em que abre as portas de seu território em busca de ampliar o desenvolvimento socioeconômico da região. O intento de ampliação da abertura para o turismo e preservação das memórias materializa-se por meio de um projeto local, em fase inicial de execução, denominado de “Ecomuseu dos Povos Caatingueiros em Gameleiras/MG”, desdobrando fatos do passado, do presente e apontando perspectivas para o futuro dos povos que encontrei nos “sopés da Serra do Espinhaço” (expressão de Cunha, 2010, P.119). Embora o texto se apresente com dupla autoria, cada autora pode falar por si em sua escrita, através do título apresentado no singular, e transpor para o papel a sua experiência de encontro e acolhimento pelos Povos Caatingueiros e a interpretação tecida a partir de cada campo de estudo: Ciências Sociais e História.
O futuro do emprego e a crise da sociedade do trabalho
Authors: Dainez Valdir , Dainez André
Published: November 2023

Esse artigo pretende discutir se é possível afirmar hoje que o desenvolvimento tecnológico está levando a uma fratura entre o crescimento dos níveis de produção e emprego e, por consequência, se estamos no limiar de uma crise da sociedade centrada no trabalho abstrato.  Argumenta-se que, ao analisarmos os países mais desenvolvidos, onde as tendências imanentes ou subjacentes à lógica de valorização capitalista estão mais desenvolvidas, não há ainda evidências estatísticas de um deslocamento da correlação entre produção e emprego.
“My Mummy Has a Hole in Her Face”: Living with Facial Eye Disfigurement
Authors: O'Dea Zali , Southcott Jane
Published: November 2023

People living with facial eye disfigurements (LwFED) are often shunned by a society that makes spontaneous judgements based on appearance. This article is a case study of the lived experience of Toni, a 27-year-old woman LwFED, the result of her treatment for ocular cancer. Semi-structured interviews facilitated the exploration of her experiences. We present the findings chronologically but interwoven with themes such as: being strong for others; responding to her partner’s abuse; dealing with strangers; and reinventing her sense of identity and supporting others. We identified institutional perspectives of work, hospital, and family within the prevailing UK that impacted Toni’s experiences of LwFED and argue that institutional perspectives need to be educated about the ordinary person’s daily grind of LwFED to address unrecognised bias and assumption. Only when identified and addressed can the reframing of social, institutional, organisational, and medical understandings and responses facilitate and support the lives of those LwFED.
Implementing Transformative Education with Participatory Action Research: A Review
Authors: Dahal Niroj
Published: November 2023

I write this review of the book, Implementing Transformative Education with Participatory Action Research, for readers, writers, and novice and veteran researchers in various social sciences disciplines and educational landscapes. The book explores using Participatory Action Research (PAR) to implement transformative education. The book argues that PAR can be used to create contextualized, sustainable, and student-centered learning environments. It offers invaluable insights from experts who have actively worked on innovative approaches to school transformation. The book also provides practical guidance and research-based strategies to help scholars effectively navigate challenges and implement transformative education. Overall, the book is a valuable resource for anyone interested in learning more about PAR and transformative education. I would highly recommend it to readers looking for ways to use research to positively impact their community of practices.
THE RELIGIOUS SOUNDSCAPE OF THE EARLY PALAEOLOGAN AGE: WHAT WAS IT REALLY LIKE?
Authors: Rodriguez Suarez Alex
Published: November 2023

This article discusses a significant element of the religious sound- scape of the Orthodox communities in the Balkans, the call to mass. The period between the Byzantine reconquest of Constantinople (1261) and the death of the Serbian King Milutin (1282–1321) witnessed the expansion of bell ringing in churches and monasteries while the semantron, the tradition- al instrument of the Byzantine Church, continued to be employed. Hence, the first decades of the Palaeologan age were crucial for the formation of a new religious soundscape that included the sounds of both church bells and semantra, that is, it was eclectic. A combination of written sources and instances of material culture attest the development of this heterogeneous soundscape. The former include references from Byzantine and Serbian sources while the latter comprises two bells cast in the thirteenth and the fourteenth century. These artefacts help us to visualise the type of church bells employed in the Balkans during the reign of King Milutin. The aim of the contribution is to provide a picture -as general as possible- of the reli- gious soundscape of the Early Palaeologan age and highlight the significant transformation that it underwent in these years.
KING MILUTIN’S BUILDING ACTIVITY IN THESSALONIKI: THE CHURCH OF TAXIARCHES AND ITS IDENTIFICATION WITH THE HILANDAR METOCHION OF ST. GEORGE
Authors: Mantopoulou Panagiotopoulou Thalia
Published: November 2023

The church of Taxiarches is one of the most important monuments of the Paleologan era in Thessaloniki. During its long life, it underwent several modifications, that blurred its original dedication and func- tion. The present study investigates the building phases of the monument and attempts their dating. It bases the research on architectural drawings, old and updated, morphological and constructional observations, Byzan- tine and modern written sources, painting analysis and dating, and urban location evidence. The study argues that Taxiarches should have been the Hilandar metochion in Thessaloniki founded by St. Savas Nemanjić at the dawn of the thirteen century and dedicated to St. George. The church itself was built on a pre-existing structure. The Nemanjić church was burnt and collapsed. In 1316−17 it was restored and decorated by King Milutin.
UMETNIČKO – ISTORIJSKE VEZE KRAJEM 13. I POČETKOM 14. VEKA: ZAJEDNIČKE TEME U SRPSKOJ I ITALIJANSKOJ UMETNOSTI
Authors:   University of Kragujevac, Faculty of Philology and Arts, Pajić Sanja , Damiko Roza G.
Published: November 2023

The paper considers the relations between art created on the territory of the Serbian medieval state and Italian painting from the end of the 13th and the first two decades of the 14th century in the context of contemporary historical events, as well as political and family ties between the Angevin, Nemanjić and Árpád dynasties. Representations of standardized forms of rare iconographic solutions appear in the monumental painting in the endowments of King Milutin (1282–1321), spread predominantly in the art at the territory of Serbia and Macedonia. The monumental Mother of God Pelagonitissa was shown in the church of the mon- astery in Staro Nagoričino, as well as Christ’s Ascent of the Cross in its trium- phant version, while the same scene, a different iconographic scheme empha- sizing the strong emotional charge, is preserved in the church of St. Nikita in Čučer. Moreover, a fairly unknown motif of the Mother of God kissing the Son in the cradle-sarcophagus was painted on the scene of the Birth of Christ in the Sts. Joachim and Anna Church (King's Church) in Studenica. Variations of these themes appeared in Italy in the same period, most often on small-size panels. These works, intended primarily for the Franciscans, were created in the centres where this monastic order maintained strong connections with the Guelfs, the Angevin dynasty and the popes. Thus, the interpretations of the Mother of God Pelagonitissa are found primarily in Romagna and Rimini, where Giovanni da Rimini presented this theme as the central part of the triptych, on whose side wing there was, among others, the scene of the Birth of Christ with the motif of the Mother kissing the Child. The triumphant version of Christ's ascent to the cross was painted in Tuscany and Siena, while the variation seen in the fresco in Santa Maria Donnaregina Vecchia in Naples is close to the fresco from Čučer. The significant role of the political and cultural mediator of the Serbian state was confirmed in the time of Milutin and his mother Jelena, whose relations with Angevins and Franciscans, widely present in the Balkans, are well known, simultaneously being in close contacts with popes, starting with Franciscan Pope Nicholas IV.
Ugovori u privredi i prekomerno oštećenje – specifičnosti ugovora o osiguranju s obzirom na njegov aleatorni karakter
Authors: MARTINOV Darija
Published: November 2023

U većini država Evrope ugovori o privredi izuzeti su od primene instituta laesio enormis jer se od privredni- ka očekuje poseban nivo pažnje i stručnosti prilikom zaključivanja ugovora i procene vrednosti prestacija. U Zakonu o obligacionim odnosima je propisano da se lezija primenjuje i na ugovore u privredi, ali Prednacrt Građanskog Zakonika Republike Srbije predviđa da se zbog nesrazmere uzajamnih davanja ne može tražiti poništenje privrednih ugovora. Zakonodavac je takođe eksplicitno isključio primenu pravila o prekomernom oštećenju i kada je reč o aleatornim ugovorima. Istovre- meno, pravila o leziji se primenjuju na potrošačke ugo- vore kao jedan vid zaštite slabije ugovorne strane. S ob- zirom na specifičnu prirodu ugovora o osiguranju koji predstavlja jedan vid potrošačkih ugovora, ali i sporna shvatanja o tome da li je pravna priroda ovog ugovora suštinski aleratorna, u ovom radu najpre vršimo pregled i detaljnu analizu argumenata za oprečne stavove o opravdanosti primene instituta lezije na ugovor o osiguranju. Kao zaključak potom dajemo i naš odgovor na to pitanje, potkrepljen adekvatnom pravnom argumentacijom.
Momordica charantia (bitter gourd), a potent antidiabetic phytomedicine
Authors: Anil Anil Kumar , Samanta Krishanu
Published: November 2023

Gourd bitter Grown mostly in India, China, and Southeast Asia, the tropical creeping plant known as or bitter melon. Its edible fruit is the primary reason for the plant's cultivation. Because of their bitter flavour, bitter gourds are not well-liked. The fruits of the Cucurbitaceae family plant Momordica charantia are a good source of a number of important nutrients. Over sixty phytomedicines, including blood purifiers, antioxidants, anticancer agents, and diabetes inhibitors, are present in the entire plant. In-depth information about the nutritional elements, different bioactive substances, and significant nutraceutical qualities of the bitter gourd plant in relation to diabetes are attempted to be provided in this review.
A tánc által jobbá tenni a világot?
Authors: Kovács Nóra
Published: November 2023

Az írás az utóbbi Dana Mills szenvedélyes nyelven írt esszékötetének recenziója, amelyben a baloldali ideológiák, a marxizmus szellemi öröksége, valamint a mozgalmi radikalizmus összekapcsolódik a tánc éteri, ám a test és az érzékek által meghatározott világával.
Dance-Related Research In Tertiary Education : A Systematic Literature Review
Authors: Lanszki Anita , Tongori Ágota , Papp-Danka Adrienn
Published: November 2023

The purpose of this article is to map the landscape of the most recent dance-related research in higher education. Research results from the last ten years, consisting of 69 reviewed articles in total, are overviewed in a systematic literature review based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol. The research presents the current state of multidisciplinary dance research in higher education regarding (1) the most frequently examined dance types in dance research, (2) the countries most typically represented in dance research in higher education contexts, (3) the tendencies in research design, (4) the types of research instruments employed, and (5) the most prominent research topics in dance research in the last ten years.
Buccal Patches: A Comprehensive review
Authors: Prajapati Shivani , Joshi Aparna , Kumar Kapil , Rajput Vaishali , Ikram
Published: November 2023

The buccal mucosa is one of the administration sites that might provide an alternative for peroral administration. The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Buccal delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. Buccal drug delivery system in which drug enters directly in systemic circulation thereby by passing the first pass effect. This is painless and without discomfort, precise dosage form and facilitates ease of removal without significant associated pain. Moreover it shows better stability, patient compliance; uniform and sustained drug release and above all easy and cheap methods of preparation which can be done with various commonly available biocompatible polymers. The buccal  route has been researched for a wide variety of drugs and has gained significant attention and momentum since it offers remarkable advantages. Over past few decades, buccal route for systemic drug delivery using mucoadhesive polymers to significantly improve the performance of many drugs has been of profound interest. Present article deals with the different aspect of the buccal patches.
Relação entre consumo de eletricidade e PIB no Brasil: uma análise a nível setorial e regional
Authors:   , Barbosa Paulo André Manhães
Published: November 2023

Diante da relevância da eletricidade como uma das principais fontes de energia utilizadas em diferentes atividades produtivas, o presente estudo investigou o papel do consumo de energia elétrica na sua relação com o nível de produto da economia brasileira, tendo como base uma análise agregada e desagregada a nível setorial/regional para o período de 1989 a 2017. A partir de uma abordagem baseada em técnicas econométricas no contexto de dados em painel, o teste de não causalidade de Dumitrescu e Hurlin (2012) foi empregado para examinar a existência e a direção da relação de causalidade no sentido de Granger entre o Produto Interno Bruto (PIB) e o consumo de eletricidade na economia brasileira como um todo e, para dois importantes setores produtivos, indústria e comércio/serviços, considerando um conjunto de dados a nível estadual. Os resultados apontaram para a presença de causalidade bidirecional entre o nível de produto agregado e o consumo agregado de eletricidade (hipótese de feedback). Para o setor industrial, foi constatada a presença de causalidade unidirecional partindo do PIB setorial para o consumo de eletricidade setorial (hipótese de conservação). Já para o setor de comércio/serviços, foi constatada causalidade unidirecional do consumo de eletricidade setorial para o nível de produto setorial (hipótese de crescimento). No que se refere à análise a nível regional, os resultados se mostraram bastante heterogêneos tanto a nível agregado quanto setorial, indicando a importância do emprego de políticas energéticas que levem em consideração as especificidades de cada estado e região do país. De modo geral, os resultados permitiram concluir que tanto políticas de incentivo à ampliação da oferta de energia elétrica quanto de incentivo à conservação do seu consumo têm o poder de influenciar a atividade econômica do Brasil a depender do setor e da região em que são empregadas pelos formuladores de políticas econômicas e energéticas. Palavras-chave: Consumo de eletricidade. PIB. Brasil.
Study of the anticonvulsant activity of the original valproic acid amino ester in various models of convulsive syndrome
Authors: Melekhova Aleksandra S. , Shustov Evgeniy B. , Zorina Veronika N. , Bespalov Aleksandr Ya. , Mel’nikova Margarita V. , Belskaya Alisa V. , Bondarenko Anastasiya A.
Published: November 2023

Introduction. Despite a significant number of antidotes (atropine, pyridoxine) and anti-seizure drugs in clinical practice (benzodiazepines, barbiturates, valproates, anesthetics), the development of new antidotes for the relief of refractory seizures and recurrence of convulsive syndrome is actual problem.
The aim of the work was to study the specific pharmacological activity of a new original derivative of valproic acid in an experiment on models of convulsive syndrome with different mechanisms of action.
Material and methods. A comparative study of the effectiveness of the original substance ((1-methylpiperidin-4-yl)-2-propylpentanoate hydrochloride, VAA) was carried out on electroshock, GABA-lytic, catecholamine-dependent seizure models in rats and mice.
Results. A significant decrease in seizure activity was revealed in the group with prophylactic administration
of VAA in the dose range of 11, 27 and 65 mg/kg in comparison with the control group received only phenylcarbamate. In an intergroup comparison, a low dose (11 mg/kg) more than others had an effect on the latent period of the onset of phenylcarbamate seizures, an average dose (27 mg/kg) reduced the duration of the seizure period, a high dose (65 mg/kg) affected the severity of convulsions, while the integral indicator (convulsive activity) did not differ between the medium and high dose subgroups. There was no significant decrease in seizure activity in models with the use of corazol, camphor, and the model of maximum electric shock.
Limitations. Testing of new pharmaceutical substances (study of efficacy and safety) should be carried out on laboratory animals before confirmation of efficacy in humans. The quantity of animals was limited by the need to comply with bioethical principles and sufficient number for statistically significant results and amounted
6 individuals in each group.
Conclusion. The release of valproic acid during the metabolism of VAA is slow and its concentration is insufficient to realize the universal anticonvulsant activity of VAA. It is necessary to further study the effect on cognitive functions and neuroprotective properties. Since antidote efficacy superior to atropine has been previously demonstrated, VAA is recommended for development as an antidote for organophosphorus poisoning.
Comparison Of Learning Styles Used By Clinical Faculty Of Hospital And General Practitioners For Their Professional Development
Authors: Atique Muhammad
Published: November 2023

Aims & Objectives: To compare the learning styles used by hospital clinical faculty and general practitioners for their professional development/ continued medical education.
Place and Duration of Study: This was a Comparative cross-sectional study carried out at Pakistan Kidney and Liver institute and research canter Lahore from October 2019 to November 2020.
Material & Methods: Total number of seventy-six medical professionals comprising thirty-eight members of clinical faculty and similar number of general practitioners were included in the study. Amongst these, 45 were males and 31 females’ Learning style questionnaire adopted from Honey and Mumford was distributed to all the participants. According to the learning styles they were grouped into Activists, reflectors, theorists and pragmatists with preference categorization of Very strong, strong, moderate, low and very low. Data was entered and analyzed usin SPSS version 22 Chi-square test was applied to see the significant difference in two groups and P value was calculated and value of less than 0.05 was considered significant.
Results: There were 45 males and 31 females with ratio of 1.45:1 .In general practitioners the strongest learning style was reflector, followed by theorist, activist and pragmatists.While in the clinical faculty the strongest preference was again for reflectors, followed by activists then theorists and finally pragmatists, the significant difference statistically was only seen in the moderate preference in activist group which was 0.038.
Conclusion: Reflector type of learning style based on pondering, experiencing and observing different perspectives was strongly observed in both genders of consultants and general practitioners. However, a moderate degree of activist type of learning style influenced by doing and feeling was also noted in the general practitioners. Further planning instructional strategy and assessment based on these learning styles could benefit the career growth of these two groups of health professionals.
Trans-Arterial Chemoembolization for the Treatment of Hepatocellular Carcinoma: A Single Tertiary Care Institute Experience
Authors: Parvez Ahmed  , Nasreen Naz  , Amjad Sattar  , Nauman al Qamari  , Imtiaz Ali  , Faryal Farooq  , Muhammad Asadullah  , Rakesh Kumar
Published: November 2023

Introduction: Trans-arterial chemoembolization (TACE) is a mainstay therapeutic option indicated in early-stage non- resectable hepatocellular carcinoma (HCC) and has been shown to be associated with survival improvements. This study aimed to evaluate the radiological and clinical response of those who underwent TACE.
Aims & Objectives: We aimed to evaluate the radiological and clinical response in patients who underwent Trans- arterial chemoembolization.
Place and Duration of Study: This study was conducted in the Vascular Interventional Radiology Department, Dow Institute of Radiology, Dow University of Health Sciences, Ojha Campus Karachi for a period of 18 months between January 2021 and June 2022.
Material & Methods: HCC patients (n=181) who underwent TACE as their primary treatment at Dow Hospital Ojha Campus Karachi between January 1st, 2021, and June 30th, 2022 were included. Inclusion criteria followed the Barcelona Clinic Liver Cancer (BCLC) and Child-Pugh staging systems. Tumor response was evaluated using “modified Response Evaluation Criteria in Solid Tumors (mRECIST)”, and patients were categorized into complete response (CR) or partial response (PR) groups. The study compared background, clinico-laboratory, and radiological features between these groups, including HCC sizes and CT scan findings before and after TACE. The retrieved data was entered and analyzed using SPSS version.21.
Results: Of the total 118 patients, 51.70% showed CR to the TACE, while PR was noted in 48.30%. Age, sex, viral hepatitis, and co-morbids showed no intergroup differences. However, Child-Pugh stage and BCLC were significantly associated with tumor response. Similarly, laboratory parameters revealed significant mean differences between the two groups (p<0.001), except international normalized ratio and alanine transaminase. Those who had achieved CR had a mean number of tumor less than that of PR. Similarly, tumor size significantly decreased post-TACE (p<0.0001). Moreover, arterial-phase enhancement and portal venous and delayed phases washout tumors before TACE were reported in 76.30%. Over half of the patients had no residual tumor tissue after TACE. Tumors with arterial-phase enhancement and portal venous and delayed phases washout were highly susceptible to TACE.Furthermore, Child-Pugh classA had a greater estimated mean survival than class B (p<0.001).
Conclusion: Over half of the patients showed complete response to the TACE. BCLC staging (B), Child-Pugh (stage A), and small tumors had a favourable effect on the radiological and clinical response in the early-stages of HCC. Tumors with an arterial-phase enhancement and portal venous and delayed phases washout were more susceptible to TACE.
Temporal Trends and Spectrum of Pediatric Surgical Conditions Operated In A Tertiary Care Teaching Hospital In Pakistan
Authors: Noor Ul Sabah Butt  , Mudassar Fiaz Gondal  , Jawad Abbasi  , Sajeel Saeed  , Omer Fraz  , Faizan Fazal
Published: November 2023

Introduction: Knowing the temporal trends as to when and how many pediatric surgery patients present and are operated on in a newly developed unit is crucial in the allocation of resources and policy making in health care center.
Aims & Objectives: The aim of this study is to describe the spectrum and pattern of operated pediatric surgery patients in a newly developed pediatric surgical unit of Pakistan.
Place and Duration of Study: This study was conducted at Pardiatric Surgery Unit of Holy Family hospital, Rawalpindi between January 2020 and September 2021.
Material & Methods: This was a retrospective descriptive study conducted on all patients that were operated under Pediatric surgery unit over a period of 20-months. Data regarding age, sex, diagnosis, and procedure performed were obtained. Diagnoses were categorized based on organ system. SPSS version 22 was used to perform the data analysis., a p-value of ?0.05 was considered significant.
Results:898 procedures were performed in total with a male to female ratio of 2.03:1. Most of the patients fell under 2-8 years of age. Digestive system disorders (164, 18.3%) and genitourinary (377, 42%) made most of the cases observed, with inguinal hernias making up to 15.0% of all cases. Oddsratio was calculated for different variables which showed that male patients , patients with gastrointestinal problems had greater odds of being operated.
Conclusion: The expected number of operated cases in a newly developed unit is comparable to other units that have been established for a long time.More focus research needs to be done on different aspects of pediatric surgery in our region and to try for integration of pediatric surgery into public health programs including primary and secondary health centers to meet the increasing demand of pediatric surgical patients presented to tertiary care.
Primer registro fotográfico de la guagua loba Dinomys branickii (Rodentia: Dinomyidae) en el departamento de Norte de Santander, Colombia
Authors: Baron-Prieto Freddy A. , Aya-Cuero Carlos A. , Correa-Hernández Karol L. , Cáceres-Martínez Carlos Herney
Published: November 2023

La Guagua loba, Dinomys branickii (Peters 1873), es el segundo roedor más grande de Colombia y el único representante de la familia Dinomyidae. Para el departamento de Norte de Santander la única evidencia conocida se encuentra depositada en la colección científica del Instituto Alexander von Humboldt (IAvH) - Bogotá, correspondiente a una piel donada por cazadores en la región de río Negro, vereda El Diamante, municipio de Toledo. Se presentan los primeros registros con cámaras trampa. Estos corresponden a un macho juvenil y una cría en el municipio de Los Patios, Norte de Santander. Los registros son los más septentrionales del área de distribución de la especie y muestran la importancia del fototrampeo para detectar especies raras, cripticas o poco conocidas. Se hace necesario recopilar más información sobre los mamíferos en ecosistemas transformados, establecer programas de monitoreo y conservación de esta especie en la región y establecer estrategias para conectar los relictos de Bs-T que aún persisten.
Therapeutic Effects of Zea Mays Husk Extracts on the Behavioural and Haematological Alterations of Pseudomonas Aeruginosa sInfected Clarias Gariepinus
Authors: Ukwe I. O. K. Abu O. M. G. , S. Audu
Published: November 2023

The present study examined the behavioural and haematological alterations in Clarias gariepinus infected with Pseudomonas aeruginosa and exposed to Zea mays husk aqueous extract. One twenty (120) fish were infected via intra-peritoneal injection with 1.0ml of 1.5×105 cfu/ml of P. aeruginosa. After the infection the infected fish were distributed into four (4) different groups in triplicate. The four groups were treated with Zea mays husk aqueous extract via immersion in four different concentrations (treatments): 0ml/l (untreated), 10ml/l, 20ml/l, 30ml/l for a period of 9 days and water exchange was done every two days (48 hours). After infection behavioural changes such as poor swimming, air gasping, restlessness, serious wounds, discolouration of fins, loss of reflex, and loss of appetite were observed manually in the experimental fish at day 3, 6 and 9. Blood was extracted after day 3, 6 and 9 of treatment and taken to the laboratory for haematological analysis and results were compared to the control to ascertain the therapeutic effect of Zea mays husk aqueous extracts. Haematological parameters such as Pack Cell Volume (PCV), Hemoglobin (HB), Red Blood Cell (RBC), White Blood Cell (WBC), Platelets (PLT), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC) and Mean Corpuscular Volume (MCV) were determined in the experimental fish after day 3, 6 and 9 of treatment. Behavioural changes were more noticeable in the untreated (control) when compared to fish exposed to the various concentration of the aqueous extracts of Zea mays husk. The values of PCV, Hb and RBC decrease after infection, but there were restoration at various level of treatment. WBC and Platelets increases after infection but normalized as the period of treatment goes on MCV, MCH and MCHC decreases after infection and improve in the various treatment as the period of treatment increases. The present study has shown that Zea mays husk aqueous extracts have the capacity of normalizing alterations in the haematological parameters of P. aeruginosa infected Clarias gariepinus.
REVIEW ON CLITORIA TERNATA
Authors: Sarma D. Sai Koteswar , Kumar Deepak , Yamini C. , Santhalahari C. , Lahari C. , Kumar G. Chaitanya
Published: November 2023

Clitoria ternatea, a perennial, twining herb that is native to tropical Asia, has a long history of usage as a memory booster and anxiolytic. various portions of the plant have various components. The plant is said to include tannins, resins, starch, taraxerol, taraxerone, alkaloids, flavonoids, saponins, proteins, anthocyanins, and carbohydrates as well as other active chemical components. The plant is used to treat a variety of conditions in traditional medicine, including jaundice, migraine, throat infections, eye infections, skin illnesses, asthma, swollen joints, earaches, eruptions, fever, urinary tract infections, constipation, snakebites, headaches, indigestion, leprosy, and problems of the central nervous system. Clitotia ternatea is a plant that has historically been used for gonorrhoea, stress, infertility, and food colouring. Ayurveda has made extensive use of the plant. Pharmacologically, it has anti-inflammatory, analgesic, antimicrobial, and anxiolytic properties.
Perancangan Perangkat Real Time TDS Monitoring Pada Clarifier Tank Di Pabrik Kelapa Sawit Sungai Rungau
Authors: TAU Hanifadinna , W Novelita , Kristian Putra
Published: November 2023

Clarifier Tank adalah salah satu tangki di Stasiun Water Treatment Plant pada Pabrik Kelapa Sawit Sungai Rungau. Air keluaran dari Clarifier Tank akan diukur tingkat kekeruhannya (turbidity) dalam satuan NTU (Nephelometric Turbidity Unit) dengan standar air di bawah 3 NTU. Sampel air dari Clarifier Tank akan dibawa ke laboratorium untuk diukur menggunakan Turbidity Meter dan hanya dilakukan dua kali sehari. Atas dasar itu, perlu dirancang alat monitoring turbidity secara real time di Clarifier Tank agar turbidity dapat diketahui setiap saat. Metode pengumpulan data dilakukan dengan menggunakan beberapa teknik pengumpulan data yaitu studi literatur, observasi lapangan, dan wawancara. Alat dibuat dengan menggunakan Arduino Uno R3 sebagai Mikrokontroler, Micro SD Card Datalogger sebagai penyimpan data, dan LCD Keypad Shield sebagai penyaji data. Hasil penelitian menunjukkan alat monitoring dapat berjalan dengan baik dan dapat membantu dalam memonitor dan kontrol turbidity dengan eror yang rendah yaitu dibawah 4% dan hasil pengumpulan data menunjukkan Datalogger dapat menyimpan data setiap menitnya dengan baik. Perhitungan biaya pembuatan alat monitoring turbidity ini yaitu sebesar Rp.443.500,00 yang jika dibandingkan dengan alat komersial di Laboratorium yaitu turbidity meter, alat monitoring ini jauh lebih murah.
Analisis dan Perancangan E-ticket Metaverse Event Berbasis Midtrans Payment gateway (Studi Kasus: PT Semesta Realitas Indonesia)
Authors: Arya Syahputra Muhammad Dimas , Femy  Mulya Muhamad
Published: November 2023

Di era modern seperti sekarang ini, dunia sedang mengalami perkembangan pada bidang ilmu pengetahuan dan teknologi. Teknologi metaverse menjadi topik diskusi hangat di seluruh dunia, dengan kemampuannya menciptakan dunia virtual 3D dengan menggunakan teknologi AR dan VR dimana pengguna dapat tampil berinteraksi di dunia virtual yang nyata. PT Semesta Realitas Indonesia (Festivo) kini mengembangkan sebuah metaverse yang dapat menyajikan pengalaman baru dalam mengikuti event/festival secara virtual. Dalam pembuatan dunia metaverse, PT Semesta Realitas Indonesia (Festivo) membutuhkan sebuah website sebagai media promosi, pusat informasi, mengelola event metaverse dan tentu saja untuk transaksi ticketing secara online. Transaksi e-ticket menggunakan Midtrans payment gateway untuk mempermudah proses pembayaran. Dengan menggunakan UML yang digunakan dalam perancangan sistem dan ERD sebagai bagian dari perancangan database. Kemudian menggunakan metode Agile Scrum sebagai metode dalam pengembangan sistem. Aplikasi berbasis website ini dibangun dengan menggunakan bahasa pemrograman HTML, CSS, JavaScript, dan PHP, serta di bantu dengan framework Laravel dan Bootstrap. Hasil penelitian ini menghasilkan sebuah aplikasi berbasis website yang telah dilakukan pengujian dengan menggunakan Black-Box testing dengan tingkat keberhasilan mencapai 90%, yang berarti sistem tergolong baik. Aplikasi dapat digunakan oleh perusahaan sebagai media promosi metaverse event, dan pembelian e-ticket dengan midtrans untuk masuk ke dalam dunia metaverse event.
XINJIANG AS A KEY REGION OF THE BELT AND ROAD INITIATIVE
Authors:   L.N. Gumilyov Eurasian National University, Nechayeva Yelena , Kozhirova Svetlana ,   Institute of Oriental Studies named after R.B. Suleimenov
Published: November 2023

Xinjiang traditionally occupies an important place in Kazakh-Chinese trade and economic relations. The region is one of the key hubs between China and the countries of Central Asia under the Belt and Road Initiative launched by the Chinese government in 2013. This initiative is aimed at creating a new Modern Silk Road, which should connect China with Europe, Africa and other regions of the world. This article discusses the impact of the initiative on the economic and social development of Xinjiang, in areas such as infrastructure development, increasing trade and investment, modernizing production, etc. The study identifies some of the challenges and obstacles that the region encounters in its quest for modernization. The authors conclude that the Belt and Road Initiative has a stimulating effect on Xinjiang's economic growth and modernization, while noting a decrease in tension in the domestic political field. More efforts and investments are needed to achieve long-term sustainability and address the problems associated with uneven development, environmental challenges and other aspects that require attention.