bluuebunny/crossref_metadata_2025 huggingface dataset:
Wastewater Treatments Based on Adsorption, Catalysis, Biodegradation, and Beyond
Authors: Giannakoudakis Dimitrios A. , Sun Yongchang
Published: November 2024

The ongoing technological advancements and industrial growth over the past few decades have resulted in significant environmental challenges, with one of the most notable being water pollution caused by the improper disposal of organic and inorganic pollutants [...]
Matrix Solid-Phase Dispersion Procedure for Determination of Antibiotics and Metabolites in Mussels: Application in Exposure Bioassays
Authors: Mejías Carmen , Fonseca Tainá G. , García-Criado Noelia , Martín Julia , Santos Juan Luis , Aparicio Irene , Alonso Esteban
Published: November 2024

The presence of antibiotics in seafood for human consumption may pose a risk for consumers. Furthermore, some marine organisms, such as mussels, can result in appropriate bioindicators of marine contamination. In this work, a multiresidue analytical methodology suitable for the determination of antibiotics and metabolites in mussels is proposed. The target compounds include three sulphonamides and trimethoprim (TMP) and six of their main metabolites. Sample treatment involves extraction and clean-up in a single step using matrix solid-phase dispersion with acetonitrile. Analytical determination was carried out by liquid chromatography–tandem mass spectrometry. Good linearity (R2 > 0.99), accuracy (from 80.8 to 118%), and limits of quantification (lower than 5 ng g−1 (dry matter, dm)) were obtained for all selected compounds. The method was applied to the determination of antibiotics in mussel samples from an exposure assay with contaminated seawater with TMP and sulfamethoxazole (SMX). Both antibiotics were detected in the analysed samples with concentrations up to 77.5 ng g−1 dm. TMP was bioconcentrated to a higher extent than SMX, attributable to its higher hydrophobicity. None of the metabolites were detected. These results demonstrate that Mytilus galloprovincialis is a suitable bioindicator to assess marine pollution.
Transforming Science Education in Elementary Schools: The Power of PhET Simulations in Enhancing Student Learning
Authors: Diab Hussam , Daher Wajeeh , Rayan Baraa , Issa Nael , Rayan Anwar
Published: November 2024

In recent years, the integration of technology into education has significantly transformed teaching methods, especially in science education. Tools like PhET simulations have proven highly effective in enhancing student engagement and comprehension. Research has highlighted the value of simulation-based learning in fostering critical thinking and problem-solving skills. This study aimed to explore the impact of simulations, with a focus on PhET, on improving elementary students’ learning outcomes, an area that remains under-researched. The study compared the performance of two groups of third-grade students: one group learned about solubility using PhET simulations, while the other relied on traditional textbook instruction. Each group comprised fifty students. The study lasted for a two-month period. The instructional approach was investigative learning. Data were gathered through student responses to materials science questions aligned with Bloom’s Taxonomy, allowing for a detailed evaluation of their understanding and application of scientific concepts. Responses were assessed for accuracy and scored accordingly. We ran an independent-sample t-test to decide whether the difference in the mean score in science achievement between the two research groups was significant. The results showed that students using PhET simulations not only achieved significantly higher scores but also demonstrated their ability to explain their reasoning during problem-solving tasks. These findings emphasize the substantial advantages of incorporating digital tools like PhET simulations into elementary science education, as they enhance conceptual understanding and better equip students to tackle future scientific challenges. The present research results complement the previous research on using technology in the chemistry elementary classroom and add the issue of simulations to this research. The results of this study are centered on the topic of solubility. To broaden the generalizability of these findings, future research should examine the effects of simulations on student achievement in a wider range of elementary science topics.
Effective Piecewise Mass Distributions for Optimal Energy Eigenvalues of a Particle in Low-Dimensional Heterojunctions
Authors: Batle Josep , Ciftja Orion , Abdel-Aty Mahmoud , Hafez Mohamed Ahmed , Alkhazaleh Shawkat
Published: November 2024

Systems composed of several multi-layer compounds have been extremely useful in tailoring different quantum physical properties of nanomaterials. This is very much true when it comes to semiconductor materials and, in particular, to heterostructures and heterojunctions. The formalism of a position-dependent effective mass has proved to be a very efficient tool in those cases where quantum wells emerge either in one or two dimensions. In this work, we use a variety of mathematical theorems, as well as numerical computations, to study different scenarios pertaining to choices of a specific piecewise constant effective mass for a particle that causes its energy eigenvalues to reach an extremum. These results are relevant when it comes to practical technological applications such as modifying the optical energy gap between the first excited state and the ground state energy of the system. At the end of our contribution, we also question the physical validity of some approximations for systems with particles that possess a position-dependent mass especially for those cases in which the mass distribution is divergent.
Green Synthesis of Al-ZnO Nanoparticles Using Cucumis maderaspatanus Plant Extracts: Analysis of Structural, Antioxidant, and Antibacterial Activities
Authors: Sugitha S. K. Johnsy , Latha R. Gladis , Venkatesan Raja , Kim Seong-Cheol , Vetcher Alexandre A. , Khan Mohammad Rashid
Published: November 2024

Nanoparticles derived from biological sources are currently garnering significant interest due to their diverse range of potential applications. The purpose of the study was to synthesize Al-doped nanoparticles of zinc oxide (ZnO) from leaf extracts of Cucumis maderaspatanus and assess their antioxidant and antimicrobial activity using some bacterial and fungal strains. These nanoparticles were analyzed using X-ray diffraction (XRD), ultraviolet–visible (UV-vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDAX), transmission electron microscopy (TEM), and thermogravimetric analysis/differential thermal analysis (TG-DTA). The average crystalline size was determined to be 25 nm, as evidenced by the XRD analysis. In the UV-vis spectrum, the absorption band was observed around 351 nm. It was discovered that the Al-ZnO nanoparticles had a bandgap of 3.25 eV using the Tauc relation. Furthermore, by FTIR measurement, the presence of the OH group, C=C bending of the alkene group, and C=O stretching was confirmed. The SEM analysis revealed that the nanoparticles were distributed uniformly throughout the sample. The EDAX spectrum clearly confirmed the presence of Zn, Al, and O elements in the Al-ZnO nanoparticles. The TEM results also indicated that the green synthesized Al-ZnO nanoparticles displayed hexagonal shapes with an average size of 25 nm. The doping of aluminum may enhance the thermal stability of the ZnO by altering the crystal structure or phase composition. The observed changes in TG, DTA, and DTG curves reflect the impact of aluminum doping on the structural and thermal properties of ZnO nanoparticles. The antibacterial activity of the Al-ZnO nanoparticles using the agar diffusion method showed that the maximum zone of inhibition has been noticed against organisms of Gram-positive S. aureus compared with Gram-negative E. coli. Moreover, antifungal activity using the agar cup method showed that the maximum zone of inhibition was observed on Aspergilus flavus, followed by Candida albicans. Al-doping nanoparticles increases the number of charge carriers, which can enhance the generation of reactive oxygen species (ROS) under UV light exposure. These ROS are known to possess strong antimicrobial properties. Al-doping can improve the crystallinity of ZnO, resulting in a larger surface area that facilitates more interaction with microbial cells. The structural and biological characteristics of Al-ZnO nanoparticles might be responsible for the enhanced antibacterial activity exhibited in the antibacterial studies. Al-ZnO nanoparticles with Cucumis maderaspatanus leaf extract produced via the green synthesis methods have remarkable antioxidant activity by scavenging free radicals against DPPH radicals, according to these results.
The Neurological Impact of Leprosy: Manifestations and Treatment Approaches
Authors: Calderone Andrea , Aloisi Maria Catena , Casella Carmela , Fiannacca Salvatore , Cosenza Bruno , Quartarone Angelo , Calabrò Rocco Salvatore
Published: November 2024

Background and Objectives: Leprosy primarily affects peripheral nerves, leading to significant neurological complications such as polyneuritis, mononeurosis, and autonomic dysfunction, which contribute to severe disabilities and impaired quality of life for patients. This scoping review aims to investigate the neurological manifestations and main treatments of leprosy patients. Materials and Methods: Studies were identified from an online search of PubMed, Web of Science, Cochrane Library, Embase, and Scopus databases. This review has been registered on OSF (n) PQBYH. Results: Neurological complications of leprosy, such as neuropathy and paralysis, necessitate accurate diagnosis and treatment, as immunological reactions can exacerbate nerve damage. Various studies highlight the effectiveness of personalized therapies, such as corticosteroids, multi-drug therapy (MDT), and surgical interventions, in improving symptoms and neurological function in leprosy patients. Conclusions: Managing neurological complications of leprosy necessitates careful diagnosis and treatment, as many patients experience unresolved peripheral neuropathy despite multidrug therapy. Future research should focus on improving diagnostic tools, exploring the link between neuropathic pain and psychological issues, and developing effective vaccines and treatments to enhance patient outcomes.
Sepiolite–Chitosan–Acetic Acid Biocomposite Attenuates the Development of Obesity and Nonalcoholic Fatty Liver Disease in Mice Fed a High-Fat Diet
Authors: Niv Dalia , Anavi Eli , Yaval Laris , Abbas Atallah , Rytwo Giora , Gutman Roee
Published: November 2024

Background; obesity and nonalcoholic fatty liver disease (NAFLD) reduce life expectancy; nonoperative interventions show poor results. Individually, chitosan (1% w/w), acetic acid (AA 0.3–6.5% w/w), and sepiolite clay (5% w/w) attenuate high-fat-diet-induced obesity (DIO) via reduced energy digestibility and increased energy expenditure. Objectives; therefore, we hypothesized that a chitosan–sepiolite biocomposite suspended in AA would attenuate DIO and NAFLD to a greater extent than AA alone via its more substantial adsorption of nonpolar molecules. Methods; we tested this dietary supplement in C57BL/6J mice fed a high-fat diet (HFD) compared to an unsupplemented HFD and an HFD supplemented with a bile acid sequestrant (cholestyramine) or standalone AA. Results; biocomposite supplementation reduced DIO gain by 60% and abolished hepatic liver accumulation, whereas standalone AA showed mild attenuation of DIO gain and did not prevent HFD-induced hepatic fat accumulation. The biocomposite intake was accompanied by a lower digestibility (−4 point %) counterbalanced by increased intake; hence, it did not affect energy absorption. Therefore, DIO attenuation was suggested to be related to higher energy expenditure, a phenomenon not found with AA alone, as supported by calculated energy expenditure using the energy balance method. Conclusions; these results support further investigation of the biocomposite’s efficacy in attenuating obesity and NAFLD, specifically when applied with a restricted diet. Future studies are needed to determine this biocomposite’s safety, mechanism of action, and efficacy compared to its components given separately or combined with other ingredients.
Meal Timing and Sleep Health Among Midlife Mexican Women During the Early Stages of the COVID-19 Pandemic
Authors: Al-Hinai Maymona , Mohy Afnan , Téllez-Rojo Martha María , Torres-Olascoaga Libni A. , Bautista-Arredondo Luis F. , Cantoral Alejandra , Peterson Karen E. , Jansen Erica C.
Published: November 2024

Background/Objectives: This study aimed to examine associations between meal timing habits and sleep health in midlife Mexican women. Methods: Data comprised 379 midlife Mexican women who participated in a phone survey conducted within the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) project during the early stages of the COVID-19 pandemic. Women answered questions related to meal habits and sleep duration, latency, and quality. We used linear regression to investigate the associations between meal timing, frequency of meals/snacks, eating window (duration between first and last eating occasion of the day), duration between last meal, bedtime, sleep duration, and logistic regression to examine the associations between meal timing, sleep latency, and sleep quality, adjusting for confounders. Results: Later timing of meals throughout the day, and a shorter interval between the last meal of the day and bedtime, were associated with prolonged sleep latency and worse sleep quality. Associations with sleep duration were mixed: a longer eating window and a later largest and last meal were each associated with shorter sleep duration, while a later first meal and a shorter interval between the last meal of the day and bedtime were associated with longer sleep duration. Conclusions: Meal timing habits are associated with sleep duration, latency, and quality in midlife women.
Probiotic Therapy of Gastrointestinal Symptoms During COVID-19 Infection: A Randomized, Double-Blind, Placebo-Controlled, Remote Study
Authors: Horvath Angela , Haller Rosa , Feldbacher Nicole , Habisch Hansjörg , Žukauskaitė Kristina , Madl Tobias , Stadlbauer Vanessa
Published: November 2024

Background: The novel coronavirus (SARS-CoV-2) led to gastrointestinal manifestations in up to 50% of cases, with diarrhea being common, and probiotics have been suggested as a potential treatment. Aim: This study aimed to assess changes in the microbiome and the effects of a multispecies probiotic in patients with COVID-19 in home quarantine through a fully remote telemedical approach. Methods: Thirty patients were randomized to receive either the Ecologic AAD probiotic (Winclove Probiotics, Amsterdam, The Netherlands), on the market as OMNi-BiOTiC 10 (Allergosan, Austria), or a placebo for 30 days in a 2:1 ratio. Respiratory and gastrointestinal symptoms were monitored in 2–10-day intervals via online surveys, and five stool samples were collected during the 30-day study period for microbiome and metabolomics analyses. Twenty-four healthy volunteers served as controls. Results: Of the 30 patients, 26 completed this study (10 placebo, 16 probiotic). Patients reported respiratory symptoms and a diminished gastrointestinal quality of life, both of which improved significantly during the study period, irrespective of the intervention. Compared to controls, infected patients showed significant alterations in the fecal microbiome (p = 0.002), including an increase in Bacteroidetes and decreases in Christensenellaceae, Ruminococcaceae, and Gammaproteobacteria, along with metabolomic changes. Probiotic treatment significantly modulated the patients’ microbiome beta diversity (p = 0.001) and introduced the Enterococcus faecium W54 strain. Symptoms, COVID-19-related taxa, and the fecal metabolome were not affected by the intervention. Conclusions: Patients with mild COVID-19 disease in home quarantine exhibited respiratory symptoms, a reduced gastrointestinal quality of life, and changes in the fecal microbiome and metabolome.
Transformational Leadership and Its Impact on Job Satisfaction and Personal Mastery for Nursing Leaders in Healthcare Organizations
Authors: Notarnicola Ippolito , Duka Blerina , Lommi Marzia , Grosha Eriola , De Maria Maddalena , Iacorossi Laura , Mastroianni Chiara , Ivziku Dhurata , Rocco Gennaro , Stievano Alessandro
Published: November 2024

Background: Transformational leadership fosters trusting relationships; new visions; and personal, professional, and cultural growth. Effective leaders support their team’s motivational growth and organizational goals. This study aims to underscore the importance of transformational leadership and its various dimensions, focusing on its impact on job satisfaction and personal mastery among nursing leaders in healthcare organizations. Method: A cross-sectional design with convenience sampling was used. The evaluation tools included the Multifactor Leadership Questionnaire (MLQ-6S), the Satisfaction of Employees in Health Care (SEHC) questionnaire, and the Personal Mastery Scale (PMS). Results: The findings indicate that job satisfaction is influenced by transformational leadership, emphasizing the importance of tailored leadership development strategies within healthcare organizations. The laissez-faire leadership style was the only one showing no correlation with nurses’ job satisfaction. Other leadership styles showed significant positive or negative correlations with the analyzed variables. Conclusions: Transformational leaders are essential for fostering trust and enhancing job satisfaction in healthcare settings. Positive leadership styles contribute to higher levels of job satisfaction and personal mastery among nursing leaders. Conversely, laissez-faire and autocratic leadership styles can negatively impact performance and staff satisfaction. These findings highlight the critical role of leaders in creating positive work environments and supporting employee development and well-being in healthcare.
Evaluation of Attitudinal Beliefs Held by Medical and Nursing Students Towards Suicidal Behavior
Authors: González-Castro Thelma Beatriz , López-Narváez María Lilia , Fresán Ana , Tovilla-Zárate Carlos Alfonso , Genis-Mendoza Alma Delia , Nicolini Humberto , Sánchez de la Cruz Juan Pablo , Hernández-Díaz Yazmín
Published: November 2024

Background/Objectives: A favorable attitude towards suicidal behavior is associated with an increased risk of suicidal behavior in youth populations. Hence, the aim of the present study was to analyze attitudinal beliefs about suicidal behavior among Mexican medical and nursing students. We also compared attitudinal beliefs about suicidal behavior according to the religious affiliation of the participants. Methods: This is a cross-sectional observational study. Attitudinal beliefs about suicidal behavior were assessed using the Attitudinal Beliefs Questionnaire about Suicide Behavior (CCCS-18). We evaluated personal and family histories of suicide using the Spanish version of the MINI International Neuropsychiatric Interview. Comparative analysis between nursing and medical students was performed, using Chi-square tests for categorical variables and Student t-tests for continuous variables. Results: A total of 195 (52.2%) medical students and 178 (47.8%) nursing students participated. Medicine students reported a higher prevalence of a family history of suicide attempts and knowing someone who had tried to die by suicide compared to nursing students (p = 0.001). Regarding attitudinal beliefs—specifically, suicide in terminal patients—medical students reported higher scores than nursing students (9.50 ± 5.91 vs. 11.23 ± 6.38, p < 0.001), while the latter exhibited higher scores in attitudinal beliefs related to suicide itself (9.55 ± 4.45 vs. 7.28 ± 4.09, p < 0.001). Both groups display similar scores when compared by religious affiliation. Conclusions: Our findings show differences in attitudinal beliefs about suicidal behavior between medical and nursing students. Medical students exhibited more positive responses toward suicide in terminal patients, while nursing students had higher values for attitudinal beliefs related to suicide itself. These results could be considered in the planning of health sciences curricula in order to positively impact future suicide prevention efforts. This study was retrospectively registered at the Universidad Juarez Autónoma de Tabasco, with the registration number 20240063 on 8 June 2024.
Phase Retrieval of One-Dimensional Objects by the Multiple-Plane Gerchberg–Saxton Algorithm Implemented into a Digital Signal Processor
Authors: Karitans Varis , Ozolinsh Maris , Fomins Sergejs
Published: November 2024

In the current study, we address the phase retrieval of one-dimensional phase objects from near-field diffraction patterns using the multiple-plane Gerchberg–Saxton algorithm, which is still widely used for phase retrieval. The algorithm was implemented in a low-cost digital signal processor capable of fast Fourier transform using Q15 arithmetic, which is used by the previously mentioned algorithm. We demonstrate similarity between one-dimensional phase objects, i.e., vectors cut out of a phase map of the tertiary spherical aberration retrieved by the multiple-plane Gerchberg–Saxton algorithm, and these vectors are measured with a non-contact profiler. The tertiary spherical aberration was induced by a phase plate fabricated using grayscale lithography. After subtracting the vectors retrieved by the algorithm from those measured with the profiler, the root mean square error decreased, while a corresponding increase in the Strehl ratio was observed. A single vector of size 64 pixels was retrieved in about 2 min. The results suggest that digital signal processors that are capable of one-dimensional FFT and fixed-point arithmetic in Q15 format can successfully retrieve the phase of one-dimensional objects, and they can be used for applications that do not require real-time operation, i.e., analyzing the quality of cylindrical micro-optics.
Comparative Study of Injected Alzheimer’s Disease Models in Rats: Insights from Experimental Research
Authors: Doumar Hanane , El Mostafi Hicham , Elhessni Aboubaker , Laaziz Abderrahim , Mesfioui Abdelhalem
Published: November 2024

Background/Objectives: Alzheimer’s disease (AD) remains incurable, highlighting the need for new and diverse animal models to better understand its complex mechanisms. This study compares various injected animal models of AD, focusing on the main theories that explain the disease; Methods: Female Wistar rats (10-months old) were administered intracebroventricularly by artificial cerebrospinal fluid (aCSF) (Control), beta amyloid Aβ1-42 (BA), okadaic acid (OKA), lipopolysaccharides (LPS), buthionine sulfoximine (BSO) or by a mixture of these different molecules (MLG). Cognitive performance was assessed one week or one month after stereotaxic surgery; Results: Our results, show that only the Aβ and the MLG induced a persistence and progressive deficits in the working memory, recognition memory and spatial memory in rats. As the hippocampus (HIP) and the prefrontal cortex (PFC) are particularly involved in memory behavior, we analyzed long-term neuroadaptations in these brain subregions using spectrophotometric and histological methods to assess oxidative stress changes and neuronal loss, respectively. We found that the behavioral impairments in memory and learning were accompanied by irreversible oxidative stress changes and neurodegenerescence, particularly in the HIP; Conclusions: This study provides promising data on the modeling of AD in order to develop an effective therapeutic approach.
Integrin Targeting and Beyond: Enhancing Cancer Treatment with Dual-Targeting RGD (Arginine–Glycine–Aspartate) Strategies
Authors: Bogdanović Bojana , Fagret Daniel , Ghezzi Catherine , Montemagno Christopher
Published: November 2024

Integrins, an important superfamily of cell adhesion receptors, play an essential role in cancer progression, metastasis, and angiogenesis, establishing them as prime targets for both diagnostic and therapeutic applications. Despite their significant potential, integrin-targeted therapies have faced substantial challenges in clinical trials, including variable efficacy and unmet high expectations. Nevertheless, the consistent expression of integrins on tumor and stromal cells underscores their ongoing relevance and potential. Traditional RGD-based imaging and therapeutic agents have faced limitations, such as inconsistent target expression and rapid systemic clearance, which have reduced their effectiveness. To overcome these challenges, recent research has focused on advancing RGD-based strategies and exploring innovative solutions. This review offers a thorough analysis of the latest developments in the RGD–integrin field, with a particular focus on addressing previous limitations. It delves into new dual-targeting approaches and cutting-edge RGD-based agents designed to improve both tumor diagnosis and therapeutic outcomes. By examining these advancements, this review illuminates new pathways for enhancing the specificity and efficacy of integrin-targeted therapies, paving the way for more effective cancer diagnosis and treatment strategies.
Nanotechnology in Pain Management
Authors: Torpey Andrew , Bellow Emily , Samojedny Veronica , Ahluwalia Sukhpreet , Desai Amruta , Caldwell William , Bergese Sergio
Published: November 2024

Chronic pain is a debilitating condition that affects millions of patients worldwide, contributing to a high disease burden and millions of dollars in lost wages, missed workdays, and healthcare costs. Opioids, NSAIDs, acetaminophen, gabapentinoids, muscle relaxants, anticonvulsants, and antidepressants are the most used medications for chronic pain and carry significant side effects, including gastric bleeding, hepatotoxicity, stroke, kidney damage, constipation, dizziness, and arrhythmias. Opioids in particular carry the risk of long-term dependence, drug tolerance, and overdose. In 2022, 81,806 people died from opioid overdose in the United States alone. Alternative treatments for chronic pain are critically needed, and nanotechnology has emerged as a promising means of achieving effective long-term analgesia while avoiding the adverse side effects associated with conventional pharmacological agents. Nanotechnology-based treatments include liposomes, Poly Lactic-co-Glycolic Acid (PLGA) and other polymeric nanoparticles, and carbon-based polymers, which can help mitigate those adverse side effects. These nanomaterials can serve as drug delivery systems that facilitate controlled release and drug stability via the encapsulation of free molecules and protein-based drugs, leading to longer-lasting analgesia and minimizing side effects. In this review, we examine the role of nanotechnology in addressing concerns associated with conventional chronic pain treatments and discuss the ongoing efforts to develop novel, nanotechnology-based treatments for chronic pain such as nanocapacitor patches, gene therapy, the use of both viral and non-viral vectors, CRISPR, and scavengers.
The Acid-Buffered Engineered Gel Promotes In Vitro Cutaneous Healing and Fights Resistant Bacteria in Wounds
Authors: Abid Fatima , Virgo Emmeline , Kennewell Tahlia Louise , Khetan Riya , Haidari Hanif , Kopecki Zlatko , Song Yunmei , Garg Sanjay
Published: November 2024

Background: Treatment of cutaneous wound infections is becoming a major clinical challenge due to the growing problem of antimicrobial resistance associated with existing wound treatments. Two prevalent pathogens in wound infections, Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), continue to present a serious challenge, underscoring the critical need for new therapeutic alternatives. Methods: Novel alginate acid-buffered gels (ABF-1, ABF-2, and ABF-3) were developed using a combination of organic acids in various concentrations and buffered at a pH of 4.5. The acid-buffering capacity of the gels was evaluated against sodium hydroxide solution and simulated wound fluid (SWF) at different wound pHs, mimicking infected and non-infected wound environments. The in vitro antibacterial activity was assessed against resistant bacterial strains (Gram-positive and Gram-negative) using a microdilution method and wound biofilm assay. The rheological properties and cell viability of the gels were evaluated and the gel showing positive cell viability was further investigated for healing ability using an in vitro wound scratch assay. Results: The gels showed promising in vitro antibacterial activity against Staphylococcus epidermidis, S. aureus, and P. aeruginosa. Gels with higher acid concentrations (ABF-1 and ABF-2) were highly effective in reducing the bacterial load in chronic biofilms of S. aureus and P. aeruginosa, while the gel with a lower acid concentration (ABF-3) showed positive effects on the viability of skin cells (over 80% cells viable) and for promoting wound closure. All three gels demonstrated excellent acid-buffering capabilities. Conclusions: The acid-buffered gels demonstrate promising in vitro antibacterial effects, indicating their potential for enhancing wound healing.
Temperature-Induced Phase Transformations in Tutton Salt K2Cu(SO4)2(H2O)6: Thermoanalytical Studies Combined with Powder X-Ray Diffraction
Authors: de Oliveira Neto João G. , Santos Ronilson S. , Abreu Kamila R. , da Silva Luzeli M. , Lang Rossano , dos Santos Adenilson O.
Published: November 2024

Tutton salts have received considerable attention due to their potential applications in thermochemical energy storage (TCHS) systems. This technology requires high-purity materials that exhibit reversible dehydration reactions, significant variations in dehydration enthalpy, and high-temperature melting points. In this study, K2Cu(SO4)2(H2O)6 Tutton salt in the form of single crystals was grown using the slow solvent evaporation method. Their structural, morphological, and thermal characteristics are presented and discussed, as well as temperature-induced phase transformations. At room temperature, the salt crystallizes in a monoclinic structure belonging to the P21/a space group, which is typical for Tutton salts. The lack of precise control over the solvent evaporation rate during crystal growth introduced structural disorder, resulting in defects on the crystal surface, including layer discontinuities, occlusions, and pores. Thermoanalytical analyses revealed two stages of mass loss, corresponding to the release of 4 + 2 coordinated H2O molecules—four weakly coordinated and two strongly coordinated to the copper. The estimated dehydration enthalpy was ≈ 80.8 kJ/mol per mole of H2O. Powder X-ray diffraction measurements as a function of temperature showed two phase transformations associated with the complete dehydration of the starting salt occurring between 28 and 160 °C, further corroborating the thermal results. The total dehydration up to ≈ 160 °C, high enthalpy associated with this process, and high melting point temperature make K2Cu(SO4)2(H2O)6 a promising candidate for TCHS applications.
Impact of High-Intensity Exercise on BDNF Levels and Its Implications in High-Performance Sport: A Systematic Review
Authors: Moreno-Infantes Fernando , Díaz-Quesada Gema , Radesca-Fabiano Krizia , Muñoz-Andradas Guilermo , Domínguez-Balmaseda Diego
Published: November 2024

The brain-derived neurotrophic factor (BDNF) is a crucial protein in the development of the cognitive system. It regulates the growth of neurons and glial cells, synaptic plasticity, and neuroprotection. Background/Objectives: It has been suggested that high-intensity exercise could modulate the mechanisms of BDNF release, with potentially significant implications in the professional sports world. However, this is not yet fully proven, and the underlying physiological alterations are unknown. Methods: This paper reviews the current scientific literature to clarify the uncertainties about how high-intensity physical exercise influences BDNF release and its relationship with high-performance sports. Results: Strenuous exercise appears to increase BDNF synthesis through the action of lactate and the PGC-1α/FNDC5 pathway. Additionally, cognitive function has been described as an element to consider for maximizing sports performance. Conclusions: In this regard, this review provides a solid starting point for further investigation into the molecular mechanisms that promote BDNF expression mediated by exercise, as well as for seeking a direct correlation between the role of cognitive development and athletic performance in high-performance athletes.
Sb(III) Removal by Granular Adsorbent Synthesized with Iron-Containing Water Treatment Residuals and Chitosan
Authors: Zeng Huiping , Zeng Yuwei , Xu He , Sun Siqi , Zhang Jie , Li Dong
Published: November 2024

In this study, chitosan and iron-containing water treatment residues were used to prepare a chitosan/Fe-sludge particle adsorbent (CHFS) via the embedding method for Sb(III) removal. Various technologies were applied to characterize the CHFS, and batch experiments were used to investigate its adsorption properties. The results show that CHFS adsorbents are amorphous and have a specific surface area (119.95 m2/g), both beneficial for adsorption. pH and ionic strength have no impact on the adsorption. Sb(III) adsorption on CHFS occurs spontaneously and endothermically. Sb(III) adsorption by CHFS matches the pseudo-second-order kinetic model and the Langmuir model better, with a maximum adsorption capacity of 24.38 mg/g. The primary adsorption mechanism for Sb(III) is the inner sphere complexation between the Sb and Fe–O bond, while other adsorption mechanisms include chelation, pore filling, and hydrogen bonding. This study offers a reference for antimony removal and resource utilization of iron sludge.
Co-Optimization of Mechanical Properties and Radiopacity Through Radiopaque Filler Incorporation for Medical Tubing Applications
Authors: Nugent Alan , Molloy Joseph , Kelly Maurice , Colbert Declan Mary
Published: November 2024

Medical tubing, particularly cardiovascular tubing, is a critical area of research where continuous improvements are necessary to advance medical devices and improve patient care. While polymers are fundamental for these applications, on their own they present several limitations such as insufficient X-ray contrasting capabilities. As such, polymer composites utilizing radiopaque fillers are a necessity for this application. For medical tubing in vivo, radiopacity is a crucial parameter that virgin polymers alone fall short in achieving due to limited X-ray absorption. To address this shortcoming, inorganic radiopaque fillers such as barium sulphate (BaSO4) and bismuth oxychloride (BiOCl) are incorporated into polymer matrices to increase the X-ray contrast of the manufactured tubing. It is also known, however, that the incorporation of these fillers can affect the mechanical, physical, and thermal properties of the finished product. This research evaluated the impact of incorporating the two aforementioned fillers into Pebax® 6333 SA01 MED at three different loading levels (10, 20, and 30 wt.%) on the physical, thermal, and mechanical properties of the composite. Composites were prepared by twin screw extrusion and injection molding followed by characterization of the mechanical (tensile, impact, and flexural), thermal (DSC), rheological (MFI), and physical (density and ash content) properties. The performed analysis shows that BiOCl enhanced the aesthetic properties, increased stiffness, and maintained flexibility while having minimal impact on the tensile and impact properties. When comparing BiOCl to BaSO4-filled composites, it was clear that depending on the application of the polymer composite, BiOCl may provide more desirable properties. The study highlights the importance of optimizing filler concentration and processing conditions to achieve desired composite properties for specific medical applications.
Influence of Hydroxyapatite and Gelatin Content on Crosslinking Dynamics and HDFn Cell Viability in Alginate Bioinks for 3D Bioprinting
Authors: Anaya-Sampayo Lina Maria , Roa Nelly S. , Martínez-Cardozo Constanza , García-Robayo Dabeiba Adriana , Rodríguez-Lorenzo Luis M.
Published: November 2024

This study investigates how varying concentrations of hydroxyapatite (OHAp) and the addition of gelatin influence the ionic crosslinking time of alginate-based bioinks, as well as the shear stress experienced by neonatal human dermal fibroblasts (HDFn) during extrusion. These factors are crucial for validating bioinks and developing viable 3D bioprinted models. Four bioink formulations were created with a 50/50 ratio of alginate to gelatin, incorporating different calcium phosphate concentrations (0%, 1%, 5%, and 10%). The bioink compositions were confirmed via Fourier Transform Infrared (FT-IR) spectroscopy, and rheological analyses evaluated their pseudoplastic behavior, printability limits, and crosslinking times. The results indicated a notable increase in the consistency index (k) from 0.32 for the 0% OHAp formulation to 0.48 for the 10% OHAp formulation, suggesting improved viscoelastic properties. The elastic modulus recovery after crosslinking rose significantly from 245 Pa to 455 Pa. HDFn experienced a shear stress of up to 1.5436 Pa at the tip during extrusion with the HDFn-ALG5-GEL5-OHAp10 bioinks, calculated at a shear rate as low as 2 s−1. Viability assays confirmed over 70% cell viability 24 h post-extrusion and 92% viability after 7 days for the 10% OHAp formulation, highlighting the potential of hydroxyapatite-enhanced bioinks in tissue engineering applications.
Nutritional Composition and Functional Properties of A. platensis-Derived Peptides: A Green and Sustainable Protein-Rich Supplement
Authors: Begum Nabila , Qi Fei , Yang Fang , Khan Qudrat Ullah , Faizan  , Fu Qiang , Li Jie , Wang Xiu , Wang Xiaoxiao , Wang Jun , Li Riwang , Liu Dahai , Zhang Wenqing
Published: November 2024

Among cyanobacterium, Arthrospira platensis (A. platensis) is a rich source of diverse bioactive compounds due to its high protein, essential amino acid, vitamin, and mineral content. A. platensis is one of the most abundant sources of protein (50–70%). In the food industry, A. platensis is being used as an ingredient for the development of food flavor, taste, and nutritional composition. Several in vitro and in vivo studies have revealed the potential use of A. platensis in the prevention and treatment of various metabolic diseases. Recently, extensive research has focused on the production and bioactivity of the A. platensis-derived bioactive peptides. A series of steps were used for the production of bioactive peptides including hydrolysis, ultrafiltration, and chromatographic techniques, coupled with an advanced detector. A. platensis peptides showed health benefits such as anti-hypertension, anti-diabetes, anti-microbial, antioxidant, anti-obesity, and anti-cancer activities. This review aims to present the main nutritional composition of A. platensis, the processes of purification, and the identification of bioactive peptides, and the potential health benefits such as antihypertensive, antidiabetic, anti-cancer, anti-obesity, antioxidant, and anti-microbial activities associated with the consumption of A. platensis-derived peptides are discussed. The originality of this review over the old review is that our review comprehensively studies the macro- and micronutrient composition and listed bioactive peptides to date, which can play an important role in the treatment of various diseases. Moreover, this review provides information related the research gaps of the various technologies that should be used for the development of the peptide as a pharmaceutical and functional food.
Current Diagnostic Challenges in Late-Life Depression and Neurocognitive Disorders
Authors: Adriani Barbara , Arena Jan Francesco , Fioretti Alessandro , Mancino Serena , Sarno Francesca , Ferracuti Stefano , Del Casale Antonio
Published: November 2024

The comorbidity between late-life depression and neurocognitive disorders (NCDs) in the elderly is a subject of increasing interest within the scientific and medical community. We conducted a narrative review of clinical studies focused on depression and NCDs, primarily covering articles published over the past 25 years. Compared with younger adults, depression in the elderly is often characterized by difficulties in expressing sadness, more pronounced somatic, anxiety, and psychotic symptoms, as well as a heightened risk of suicide and cognitive impairment. Depressive symptoms in the elderly may mimic NCDs, act as prodromal signs of future NCDs, or represent a clinical dimension of dementia. NCDs and late-life depression share specific clinical similarities, particularly at illness onset, emphasizing the importance of early differential diagnosis to guide the development of precise, integrated, and tailored interventions.
Sacred Space, Material Culture, and Ritual Practice for Installing Parasols in Dunhuang
Authors: Yu Xin
Published: November 2024

This paper aims to shed new light on the religious function and symbolic meaning of parasols (san 傘) in Buddhist ritual practices, tracing the origins of the concept and examining its representations in texts and art. The author focuses on manuscripts, particularly the “Liturgies for Installing Parasols” (Ansan wen 安傘文) from Dunhuang, and argues that parasols were used as special ritual instruments to guard the local community. Their sacred power stemmed from the apotheosis of the parasol’s practical function of shielding and protecting people, which was further enhanced by beliefs surrounding the “Mother of Buddhas with Great White Canopy” (Da bai sangai fomu 大白傘蓋佛母) in the late Tang and Five Dynasties. Erecting parasols or carrying them in processions around the city was considered equivalent to demarcating boundaries, establishing defenses, and creating sanctuaries. Whether worn as a protective object, placed at the city’s four gates as a symbol of safeguarding passage, or installed in processions, the Great White Canopy Dhāraṇī and the practice of installing parasols distinguished the inside from the outside, self from others, and purity from impurity. This practice not only had the power to expel plagues and disasters, but also solemnified spaces, bringing blessings, purification, health, and peace. The parasol’s practical functions were continuously extended and mythologized, becoming a central object in rituals aimed at sanctifying space. The rise of the Great White Canopy Dhāraṇī belief in Dunhuang further reinforced its role in local customs. This method of spatial sanctification reflects the internal logic of esoteric Buddhist practices while sharing conceptual and technical similarities with traditional Chinese apotropaic arts (fangshu 方術) and Daoist exorcistic rituals. Through the grand and regular performance of these ceremonies, political legitimacy and communal well-being were successfully established.
Simeon the God-Receiver (Luke 2:21–35) as a Translator of the Septuagint: Investigating the Sources of a Popular Hagiographic Legend in Orthodox Christianity
Authors: Oancea Constantin Horia
Published: November 2024

The legend of the old man Simeon, who received Jesus in his arms and was one of the Septuagint translators, is almost unknown in Western Christianity but is very popular today among Orthodox Christians. The version circulating in Orthodox churches is based on the account in Demetrius of Rostov’s Lives of the Saints. The article explores the occurrences of the legend in modern, medieval Slavonic, Byzantine, and oriental writings and attempts to identify the stages of the transmission of the legend from antiquity to modern times. The historical analysis and the comparison of the motifs found in these writings make the hypothesis of a Byzantine archetype of the legend plausible. This writing has been lost, but it was previously translated into Syriac, Arabic, and Slavonic, contributing to the spread of the legend in Eastern and Slavic Christianity. The legend builds on the identification of Simeon in Luke’s Gospel with Shimʿon ha-Tsaddiq. It interprets Luke 2:26 by constructing a pre-history of the episode that places Simeon into the time of the Septuagint translation. The miracle of prolonging Righteous Simeon’s life functions as a reconfirmation of the fundamental character of Isaiah 7:14 for Christianity.
Introduction: The Intersection of Religion with Radicalization and De-Radicalization Processes in Comparative Perspective
Authors: Medda-Windischer Roberta , Budabin Alexandra Cosima , Zeba Mattia
Published: November 2024

Radicalization continues to be considered a contentious concept with little consensus on what categorizes a movement or individual as “radical” (or extreme) [...]
Parotid Epithelial–Myoepithelial Carcinoma, Lymph Node Metastasis After 9 Years: A Case Report
Authors: Bianco Maria Rita , Galletti Cosimo , Maniaci Antonino , Torrice Giovanni , Allegra Eugenia
Published: November 2024

Background and Clinical Significance: Epithelial–myoepithelial carcinoma (EMC) is a rare, low-grade malignant tumor of the salivary glands. It is characterized by a low malignancy potential, as indicated by its low rate of lymph node involvement and distant metastasis, and has a local recurrence rate of approximately 50%. Due to the rarity of EMC and the limited data available in the literature, there are no established treatment or follow-up guidelines. Case Presentation: We report the case of an 83-year-old man who presented with swelling in the left submandibular region, occurring 9 years following an initial diagnosis of EMC in the ipsilateral parotid gland. After radiological examinations and an ultrasound-guided fine-needle aspiration biopsy, the patient underwent surgical excision of the lesion with a histological diagnosis of recurrence/metastasis of low-grade epithelial–myoepithelial carcinoma. Conclusions: This is the first documented case of loco-regional lymph node metastasis 9 years after an initial diagnosis of EMC of the parotid gland. Based on our experience, EMC of the parotid gland, even when diagnosed at an early stage, seems to require a long follow-up period.
Optimizing Reproductive Options for Young Women with Cervical Cancer
Authors: Mattei Giulia , Iaculli Francesco , Carbone Fabiana , Mondo Alessandro , Muzii Ludovico
Published: November 2024

Cervical cancer is one of the leading causes of mortality in women of reproductive age. In recent years, the development of preventive and therapeutic strategies has significantly increased survival rates. While this represents an important medical achievement, it has also raised a major social issue regarding the need to ensure an adequate quality of life for surviving patients. Many of these women are left without their reproductive capacity at an age when their desire for motherhood has not yet been fulfilled. Infertility or subfertility in cancer survivors is actually a growing problem, complicated by the current trend of increasingly delaying pregnancy. The psychological effects of this issue can be devastating, sometimes even more so than the cancer diagnosis itself. Although today fertility-sparing surgeries can ensure excellent reproductive outcomes with minimal oncological risk, obstetric sequelae remain significant, and affected women often require specialized care pathways. Additionally, adequate counselling is still not provided to all patients who cannot access fertility-sparing treatments and who find themselves without hope. Reproductive medicine is therefore facing the modern challenge of offering concrete options to help these patients realize their desire for motherhood. The aim of this article is to provide an overview of the therapeutic options available to young women facing an early- or later-stage diagnosis of cervical cancer.