bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Cr Addition on the Microstructure and Mechanical Properties of an Al–Si–Cu–Mg Alloy
Authors: Sun Fengshan , Wen Xin , Sun Shuaifei , Lu Yuanyuan , Xiao Wenlong , Ma Chaoli
Published: July 2024

The effects of chromium (Cr) addition ranging 0.1–0.3 wt.% on the microstructure and mechanical properties of Al–7Si–4Cu–0.25Mg (wt.%) alloy have been investigated. The cast Cr-free alloy consisted of α-Al, eutectic Si, Q-Al5Mg8Cu2Si6 and θ-Al2Cu phases. Doping of Cr resulted in the appearance of a polyhedron-shaped α-Al13Cr4Si4 phase with a cubic structure. The Al13Cr4Si4 particles were found to embed with Al2Cu blocks and bring about size reduction for the Al2Cu blocks. The area fraction of Al13Cr4Si4 monotonously increased with Cr content. After T6 treatment, the Al2Cu blocks almost fully dissolved and transformed to θ’-Al2Cu precipitates in the Cr-containing alloys. TEM observation revealed relatively large-sized θ’ precipitates attached to Al13Cr4Si4 dispersoids. The Cr-containing alloys showed impressive mechanical properties, with the peak strength up to 452 MPa at room temperature. The ductility exhibited an increasing trend with Cr content, but the strength dropped dramatically when the Cr content reached 0.3 wt.%. It is suggested that the strength contribution from the Al13Cr4Si4 phase is limited, especially at an elevated temperature.
Configurational Isomerism in Bimetallic Decametalates
Authors: Kondinski Aleksandar
Published: July 2024

In this work, we report on the development of a computational algorithm that explores the configurational isomer space of bimetallic decametalates with general formula MxM10−x′O28q. For x being a natural number in the range of 0 to 10, the algorithm identifies 318 unique configurational isomers. The algorithm is used to generate mixed molybdenum(VI)–vanadium(V) systems MoxV10−xO288− for x=0,1,2, and 3 that are of experimental relevance. The application of the density functional theory (DFT) effectively predicts stability trends that correspond well with empirical observations. In dimolybdenum-substituted decavanadate systems, we discover that a two-electron reduction preferentially stabilizes a configurational isomer due to the formation of metal–metal bonding. The particular polyoxometalate structure is of interest for further experimental studies.
Proteomics Analysis of the Protective Effect of Polydeoxyribonucleotide Extracted from Sea Cucumber (Apostichopus japonicus) Sperm in a Hydrogen Peroxide-Induced RAW264.7 Cell Injury Model
Authors: Shu Zhiqiang , Ji Yizhi , Liu Fang , Jing Yuexin , Jiao Chunna , Li Yue , Zhao Yunping , Wang Gongming , Zhang Jian
Published: July 2024

Sea cucumber viscera contain various naturally occurring active substances, but they are often underutilized during sea cucumber processing. Polydeoxyribonucleotide (PDRN) is an adenosine A2A receptor agonist that activates the A2A receptor to produce various biological effects. Currently, most studies on the activity of PDRN have focused on its anti-inflammatory, anti-apoptotic, and tissue repair properties, yet relatively few studies have investigated its antioxidant activity. In this study, we reported for the first time that PDRN was extracted from the sperm of Apostichopus japonicus (AJS-PDRN), and we evaluated its antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), and hydroxyl radical scavenging assays. An in vitro injury model was established using H2O2-induced oxidative damage in RAW264.7 cells, and we investigated the protective effect of AJS-PDRN on these cells. Additionally, we explored the potential mechanism by which AJS-PDRN protects RAW264.7 cells from damage using iTRAQ proteomics analysis. The results showed that AJS-PDRN possessed excellent antioxidant activity and could significantly scavenge DPPH, ABTS, and hydroxyl radicals. In vitro antioxidant assays demonstrated that AJS-PDRN was cytoprotective and significantly enhanced the antioxidant capacity of RAW264.7 cells. The results of GO enrichment and KEGG pathway analysis indicate that the protective effects of AJS-PDRN pretreatment on RAW264.7 cells are primarily achieved through the regulation of immune and inflammatory responses, modulation of the extracellular matrix and signal transduction pathways, promotion of membrane repair, and enhancement of cellular antioxidant capacity. The results of a protein–protein interaction (PPI) network analysis indicate that AJS-PDRN reduces cellular oxidative damage by upregulating the expression of intracellular selenoprotein family members. In summary, our findings reveal that AJS-PDRN mitigates H2O2-induced oxidative damage through multiple pathways, underscoring its significant potential in the prevention and treatment of diseases caused by oxidative stress.
Combining In Vitro, In Vivo, and Network Pharmacology Assays to Identify Targets and Molecular Mechanisms of Spirulina-Derived Biomolecules against Breast Cancer
Authors: Hassanin Soha Osama , Hegab Amany Mohammed Mohmmed , Mekky Reham Hassan , Said Mohamed Adel , Khalil Mona G. , Hamza Alaaeldin Ahmed , Amin Amr
Published: July 2024

The current research employed an animal model of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary gland carcinogenesis. The estrogen receptor-positive human breast adenocarcinoma cell line (MCF-7) was used for in vitro analysis. This was combined with a network pharmacology-based approach to assess the anticancer properties of Spirulina (SP) extract and understand its molecular mechanisms. The results showed that the administration of 1 g/kg of SP increased the antioxidant activity by raising levels of catalase (CAT) and superoxide dismutase (SOD), while decreasing the levels of malonaldehyde (MDA) and protein carbonyl. A histological examination revealed reduced tumor occurrence, decreased estrogen receptor expression, suppressed cell proliferation, and promoted apoptosis in SP protected animals. In addition, SP disrupted the G2/M phase of the MCF-7 cell cycle, inducing apoptosis and reactive oxygen species (ROS) accumulation. It also enhanced intrinsic apoptosis in MCF-7 cells by upregulating cytochrome c, Bax, caspase-8, caspase-9, and caspase-7 proteins, while downregulating Bcl-2 production. The main compounds identified in the LC-MS/MS study of SP were 7-hydroxycoumarin derivatives of cinnamic acid, hinokinin, valeric acid, and α-linolenic acid. These substances specifically targeted three important proteins: ERK1/2 MAPK, PI3K-protein kinase B (AKT), and the epidermal growth factor receptor (EGFR). Network analysis and molecular docking indicated a significant binding affinity between SP and these proteins. This was verified by Western blot analysis that revealed decreased protein levels of p-EGFR, p-ERK1/2, and p-AKT following SP administration. SP was finally reported to suppress MCF-7 cell growth and induce apoptosis by modulating the PI3K/AKT/EGFR and MAPK signaling pathways suggesting EGFR as a potential target of SP in breast cancer (BC) treatment.
Immunomodulatory Effect of Cordyceps militaris Polysaccharide on RAW 264.7 Macrophages by Regulating MAPK Signaling Pathways
Authors: Liu Yan , Yang Jiayi , Guo Zhijian , Li Qizhang , Zhang Lida , Zhao Lingxia , Zhou Xuanwei
Published: July 2024

Polysaccharide is one of the principal bioactive components found in medicinal mushrooms and has been proven to enhance host immunity. However, the possible mechanism of immunomodulatory activity of Cordyceps militaris polysaccharide is not fully understood. Hot water extraction and alcohol precipitation, DEAE-Sephadex A-25 chromatography, and Sephadex G-100 chromatography were used to isolate polysaccharide from C. militaris. A high-molecular-weight polysaccharide isolated from C. militaris was designated as HCMP, which had an Mw of 6.18 × 105 Da and was composed of arabinose, galactose, glucose, mannose, and xylose in a mole ratio of 2.00:8.01:72.54:15.98:1.02. The polysaccharide content of HCMP was 91.2% ± 0.16. The test in vitro showed that HCMP activated mouse macrophage RAW 264.7 cells by enhancing phagocytosis and NO production, and by regulating mRNA expressions of inflammation-related molecules in RAW 264.7 cells. Western blotting revealed that HCMP induced the phosphorylation of mitogen-activated protein kinases (MAPKs). Moreover, using inhibitors of MAPKs decreased the mRNA levels of inflammation-related molecules induced by HCMP. These data evidenced that the immunomodulatory effect of HCMP on RAW 264.7 macrophages was mediated via the MAPK signaling pathway. These findings suggested that HCMP could be developed as a potent immunomodulatory agent for use in functional foods and dietary supplements.
Identification and Characterization of a Novel Prophage Lysin against Streptococcus dysgalactiae
Authors: Xu Linan , Li Xingshuai , Yang Xiangpeng , Zhao Yuzhong , Niu Jianrui , Jiang Shijin , Ma Junfei , Zhang Xinglin
Published: July 2024

Streptococcus dysgalactiae infection can cause bovine mastitis and lead to huge economic losses for the dairy industry. The abuse of antibiotics has resulted in growing drug resistance of S. dysgalactiae, which causes hard-to-treat infections. Bacteriophage lysin, as a novel antibacterial agent, has great potential for application against drug-resistant gram-positive bacteria. However, few studies have been conducted on the prophage lysin of S. dysgalactiae. In this study, we mined a novel prophage lysin, named Lys1644, from a clinical S. dysgalactiae isolate by genome sequencing and bioinformatic analysis. Lys1644 was expressed and purified, and the lytic activity, antibacterial spectrum, optimal pH and temperature, lytic activity in milk in vitro, and synergistic bacteriostasis with antibiotics were assessed. The Lys1644 prophage lysin showed high bacteriolysis activity specifically on S. dysgalactiae, which resulted in CFU 100-fold reduction in milk. Moreover, Lys1644 maintained high activity over a wide pH range (pH 5–10) and a wide temperature range (4–42 °C). Synergistic bacteriostatic experiments showed that the combination of low-dose Lys1644 (50 μg/mL) with a subinhibitory concentration of aminoglycoside antibiotics (kanamycin or spectinomycin) can completely inhibit bacterial growth, suggesting that the combination of Lys1644 and antibiotics could be an effective therapeutic strategy against S. dysgalactiae infection.
Enhancing Bioactivity through the Transfer of the 2-(Hydroxymethoxy)Vinyl Moiety: Application in the Modification of Tyrosol and Hinokitiol
Authors: Molski Marcin
Published: July 2024

Utilizing Density Functional Theory (DFT) calculations at the B3LYP/QZVP level and incorporating the Conductor-like Polarizable Continuum Model (C-PCM) for solvation, the thermodynamic and chemical activity properties of 21-(hydroxymethoxy)henicosadecaenal, identified in cultured freshwater pearls from the mollusk Hyriopsis cumingii, have been elucidated. The study demonstrates that this compound releases formaldehyde, a potent antimicrobial agent, through dehydrogenation and deprotonation processes in both hydrophilic and lipophilic environments. Moreover, this polyenal exhibits strong anti-reductant properties, effectively scavenging free radicals. These critical properties classify the pearl-derived ingredient as a natural multi-functional compound, serving as a coloring, antiradical, and antimicrobial agent. The 2-(hydroxymethoxy)vinyl (HMV) moiety responsible for the formaldehyde release can be transferred to other compounds, thereby enhancing their biological activity. For instance, tyrosol (4-(2-hydroxyethyl)phenol) can be modified by substituting the less active 2-hydroxyethyl group with the active HMV one, and hinokitiol (4-isopropylotropolone) can be functionalized by attaching this moiety to the tropolone ring. A new type of meso-carrier, structurally modeled on pearls, with active substances loaded both in the layers and the mineral part, has been proposed.
Palladium(II) and Platinum(II) Complexes Bearing ONS-Type Pincer Ligands: Synthesis, Characterization and Catalytic Investigations
Authors: Castiñeiras Alfonso , García-Santos Isabel
Published: July 2024

This work describes the synthesis of eight new Pd(II) and Pt(II) complexes with the general formula [M(TSC)Cl], where TSC represents the 4N-monosubstituted thiosemicarbazone derived from 2-acetylpyridine N-oxide with the substituents CH3 (H4MLO), C2H5 (H4ELO), phenyl (H4PLO) and (CH3)2 (H4DMLO). These complexes have been characterized by elemental analysis, molar conductivity, IR spectroscopy, 1H, 13C, 195Pt and ESI-MS. The complexes exhibit a square planar geometry around the metallic center coordinated by a thiosemicarbazone molecule acting as a donor ONS-type pincer ligand and by a chloride, as confirmed by the molecular structures of the complexes, [Pd(4ELO)Cl] (3) and [Pd(4PLO)Cl] (5), determined by single-crystal X-ray diffraction. The 195Pt NMR spectra of the complexes of formulae [Pt(4PLO)Cl] (6) and [Pt(4DMLO)Cl] (8) in DMSO show a single signal at −2420.4 ppm, confirming the absence of solvolysis products. Complexes 3 and 5 have been tested as catalysts in the Suzuki–Miyaura cross-coupling reactions of aryl bromides with phenylboronic acid, with yields of between 50 and 90%
Infrared Lightwave Memory-Resident Manipulation and Absorption Based on Spatial Electromagnetic Wavefield Excitation and Resonant Accumulation by GdFe-Based Nanocavity-Shaped Metasurfaces
Authors: Chen Cheng , Zhang Chuang , Liu Taige , Wang Zhe , Shi Jiashuo , Zhang Xinyu
Published: July 2024

An arrayed nanocavity-shaped architecture consisting of the key GdFe film and SiO2 dielectric layer is constructed, leading to an efficient infrared (IR) absorption metasurface. By carefully designing and optimizing the film system configuration and the surface layout with needed geometry, a desirable IR radiation absorption according to the spatial magnetic plasmon modes is realized experimentally. The simulations and measurements demonstrate that GdFe-based nanocavity-shaped metasurfaces can be used to achieve an average IR absorption of ~81% in a wide wavelength range of 3–14 μm. A type of the patterned GdFe-based nanocavity-shaped metasurface is further proposed for exciting relatively strong spatial electromagnetic wavefields confined by a patterned nanocavity array based on the joint action of the surface oscillated net charges over the charged metallic films and the surface conductive currents including equivalent eddy currents surrounding the layered GdFe and SiO2 materials. Intensive IR absorption can be attributed to a spatial electromagnetic wavefield excitation and resonant accumulation or memory residence according to the GdFe-based nanocavity-shaped array formed. Our research provides a potential clue for efficiently responding and manipulating and storing incident IR radiation mainly based on the excitation and resonant accumulation of spatial magnetic plasmons.
Digestive Profiles of Human Milk, Recombinant Human and Bovine Lactoferrin: Comparing the Retained Intact Protein and Peptide Release
Authors: Kim Bum Jin , Kuhfeld Russell F. , Haas Joanna L. , Anaya Yanisa M. , Martinez Raysa Rosario , Sah Baidya Nath P. , Breen Bella , Newsham Kahler , Malinczak Carrie-Anne , Dallas David C.
Published: July 2024

Lactoferrin (LF) is a major component of human milk. LF supplementation (currently bovine) supports the immune system and helps maintain iron homeostasis in adults. No recombinant human lactoferrin (rhLF) is available for commercial food use. To determine the extent to which rhLF (Effera™) produced by Komagataella phaffii digests similarly to hmLF, a validated in vitro digestion protocol was carried out. Bovine LF (bLF) was used as an additional control, as it is approved for use in various food categories. This study compared the extent of intact protein retention and the profile of peptides released in hmLF, bLF and rhLF (each with low and high iron saturation) across simulated adult gastric and intestinal digestion using gel electrophoresis, ELISA and LC-MS. Intact LF retention across digestion was similar across LF types, but the highest iron-saturated hmLF had greater retention in the simulated gastric fluid than all other sample types. Peptides identified in digested hmLF samples strongly correlated with digested rhLF samples (0.86 < r < 0.92 in the gastric phase and 0.63 < r < 0.70 in the intestinal phase), whereas digested bLF samples were significantly different. These findings support the potential for rhLF as a food ingredient for human consumption.
Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3
Authors: Daida Tomoko , Shin Bo-Chul , Cepeda Carlos , Devaskar Sherin U.
Published: July 2024

Glucose is the primary energy source for most mammalian cells and its transport is affected by a family of facilitative glucose transporters (GLUTs) encoded by the SLC2 gene. GLUT1 and GLUT3, highly expressed isoforms in the blood–brain barrier and neuronal membranes, respectively, are associated with multiple neurodevelopmental disorders including epilepsy, dyslexia, ADHD, and autism spectrum disorder (ASD). Dietary therapies, such as the ketogenic diet, are widely accepted treatments for patients with the GLUT1 deficiency syndrome, while ameliorating certain symptoms associated with GLUT3 deficiency in animal models. A ketogenic diet, high-fat diet, and calorie/energy restriction during prenatal and postnatal stages can also alter the placental and brain GLUTs expression with long-term consequences on neurobehavior. This review focuses primarily on the role of diet/energy perturbations upon GLUT isoform-mediated emergence of neurodevelopmental and neurodegenerative disorders.
Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models
Authors: Márquez-Garbán Diana C. , Yanes Cristian D. , Llarena Gabriela , Elashoff David , Hamilton Nalo , Hardy Mary , Wadehra Madhuri , McCloskey Susan A. , Pietras Richard J.
Published: July 2024

Manuka honey (MH) exhibits potential antitumor activity in preclinical models of a number of human cancers. Treatment in vitro with MH at concentrations ranging from 0.3 to 5.0% (w/v) led to significant dose-dependent inhibition of proliferation of human breast cancer MCF-7 cells, but anti-proliferative effects of MH were less pronounced in MDA-MB-231 breast cancer cells. Effects of MH were also tested on non-malignant human mammary epithelial cells (HMECs) at 2.5% w/v, and it was found that MH reduced the proliferation of MCF-7 cells but not that of HMECs. Notably, the antitumor activity of MH was in the range of that exerted by treatment of MCF-7 cells with the antiestrogen tamoxifen. Further, MH treatment stimulated apoptosis of MCF-7 cells in vitro, with most cells exhibiting acute and significant levels of apoptosis that correlated with PARP activation. Additionally, the effects of MH induced the activation of AMPK and inhibition of AKT/mTOR downstream signaling. Treatment of MCF7 cells with increased concentrations of MH induced AMPK phosphorylation in a dose-dependent manner that was accompanied by inhibition of phosphorylation of AKT and mTOR downstream effector protein S6. In addition, MH reduced phosphorylated STAT3 levels in vitro, which may correlate with MH and AMPK-mediated anti-inflammatory properties. Further, in vivo, MH administered alone significantly inhibited the growth of established MCF-7 tumors in nude mice by 84%, resulting in an observable reduction in tumor volume. Our findings highlight the need for further research into the use of natural compounds, such as MH, for antitumor efficacy and potential chemoprevention and investigation of molecular pathways underlying these actions.
Influence of Intravenous Magnesium Sulfate Infusion on the Subjective Postoperative Quality of Recovery: A Meta-Analysis of Randomized Controlled Trials
Authors: Hung Kuo-Chuan , Chang Li-Chen , Ho Chun-Ning , Hsu Chih-Wei , Wu Jheng-Yan , Lin Yao-Tsung , Chen I-Wen
Published: July 2024

This meta-analysis investigated the effects of intravenous magnesium sulfate on the postoperative recovery quality, as assessed using the Quality of Recovery (QoR) questionnaire, in adult surgical patients. Seven randomized controlled trials involving 622 patients were included. Compared with the placebo, magnesium sulfate significantly improved the global QoR score on postoperative day 1 (standardized mean difference [SMD]: 1.24; 95% confidence interval: 0.70—1.78; p < 0.00001). It also enhanced specific QoR dimensions, with substantial effects on pain (SMD: 1, p < 0.00001) and physical comfort (SMD: 0.85, p < 0.0001), a moderate effect on emotional state (SMD: 0.65, p = 0.002), and small improvements in physical independence (SMD: 0.43, p < 0.00001) and psychological support (SMD: 0.37, p < 0.0001). In addition, magnesium sulfate reduced the intraoperative opioid consumption (SMD: −0.66, p < 0.0001), postoperative pain severity, and the incidence of postoperative nausea and vomiting (risk ratio: 0.48, p = 0.008). The extubation times were unaffected, whereas the post-anesthesia care unit stay was slightly prolonged. These findings highlight the potential of magnesium sulfate as a valuable adjunct for multimodal analgesia and enhanced recovery. Future studies should aim to elucidate the optimal dosing strategies, timing of administration, and specific surgical populations that may derive maximum benefits.
Thermally Stabilised Poly(vinyl alcohol) Nanofibrous Materials Produced by Scalable Electrospinning: Applications in Tissue Engineering
Authors: Homer W. Joseph A. , Lisnenko Maxim , Hauzerova Sarka , Heczkova Bohdana , Gardner Adrian C. , Kostakova Eva K. , Topham Paul D. , Jencova Vera , Theodosiou Eirini
Published: July 2024

Electrospinning is a widely employed manufacturing platform for tissue engineering applications because it produces structures that closely mimic the extracellular matrix. Herein, we demonstrate the potential of poly(vinyl alcohol) (PVA) electrospun nanofibers as scaffolds for tissue engineering. Nanofibers were created by needleless direct current electrospinning from PVA with two different degrees of hydrolysis (DH), namely 98% and 99% and subsequently heat treated at 180 °C for up to 16 h to render them insoluble in aqueous environments without the use of toxic cross-linking agents. Despite the small differences in the PVA chemical structure, the changes in the material properties were substantial. The higher degree of hydrolysis resulted in non-woven supports with thinner fibres (285 ± 81 nm c.f. 399 ± 153 nm) that were mechanically stronger by 62% (±11%) and almost twice as more crystalline than those from 98% hydrolysed PVA. Although prolonged heat treatment (16 h) did not influence fibre morphology, it reduced the crystallinity and tensile strength for both sets of materials. All samples demonstrated a lack or very low degree of haemolysis (<5%), and there were no notable changes in their anticoagulant activity (≤3%). Thrombus formation, on the other hand, increased by 82% (±18%) for the 98% hydrolysed samples and by 71% (±10%) for the 99% hydrolysed samples, with heat treatment up to 16 h, as a direct consequence of the preservation of the fibrous morphology. 3T3 mouse fibroblasts showed the best proliferation on scaffolds that were thermally stabilised for 4 and 8 h. Overall these scaffolds show potential as ‘greener’ alternatives to other electrospun tissue engineering materials, especially in cases where they may be used as delivery vectors for heat tolerant additives.
Development of a Zr-Based Metal-Organic Framework (UiO-66) for a Cooperative Flame Retardant in the PC/ABS
Authors: Chen Shaojun , Chen Zerui , Bi Weifeng , Du Wei , Lin Ling , Hu Dasong , Zhuo Haitao
Published: July 2024

Polycarbonate/acrylonitrile butadiene styrene (PC/ABS) blends are widely used as engineering plastic alloys; however, they have a low fire safety level. To improve the flame-retardant property of PC/ABS, a zirconium-based metal-organic framework material (UiO-66) was synthesized with zirconium chloride and terephthalic acid and used as a flame-retardant cooperative agent. Its flame-retardant performance and mode of action in the PC/ABS blends were carefully investigated. The results showed that UiO-66 had good thermal stability and delayed the pyrolysis of the materials, thus significantly enhancing the efficiency of intumescent flame retardants. By compounding 7.0 wt% hexaphenyloxy-cyclotri-phosphazene (HPCTP) with 3.0 wt% UiO-66, the PC/ABS blends reached a limiting oxygen index value of 27.0% and V0 rating in the UL-94 test, showing significantly improved resistance to combustion dripping. In addition, UiO-66 enhanced the smoke and heat suppression characteristics of the intumescent flame-retardant materials. Finally, the flame-retardant mode of action in the blends was indicative of UiO-66 having a cooperative effect on the flame-retardant performance of PC/ABS/HPCTP materials. This work provides good ideas for further development of the flame-retardant ABS/PC.
Numerical and Experimental Study on Balanced Performance and Axial Stiffness of Fiber-Reinforced Rubber Pipe
Authors: You Jingyue , Zhao Yinglong , Zhang Ben
Published: July 2024

Balanced fiber-reinforced rubber (FRR) pipes not only provide displacement compensation when transporting pressurized media but also prevent additional forces and displacements from being exerted on the connected pipeline system. Investigating the balanced performance of FRR pipes and the axial stiffness of balanced pipes is crucial for optimizing pipeline design and improving the reliability of pipeline systems. This paper develops a numerical model of FRR pipes that considers the nonlinearity of the rubber material and the interaction between the rubber matrix and fiber-reinforced layers. Using this model, the balanced performance of the pipe is calculated, and its axial stiffness under combined internal pressure and axial load is analyzed. Numerical results are compared with experimental data for validation. The results indicate that the pipe’s balance is achieved through the combined effects of the elongation and rotation of the reinforcing fibers and the deformation of the rubber matrix, highlighting the significant impact of the rubber matrix on the mechanical performance of the FRR pipe. Furthermore, the pipe’s balanced performance and axial stiffness are highly sensitive to the winding angle of reinforcing fibers. The proposed numerical model fills the gap in using numerical methods to evaluate the balanced performance of FRR pipes and provides valuable insights for their design and optimization.
Effect of Viscosity and Air Gap within the Spinneret on the Morphology and Mechanical Properties of Hollow-Fiber Polymer Membranes for Separation Performance
Authors: Seansukato Sirisak , Ramachandran Sathish Kumar , Lamlong Sivamesh , Taweepreda Wirach , Arthanareeswaran Gangasalam
Published: July 2024

Hollow-fiber membranes for nanofiltration were prepared from the blending of Poly (ethylene glycol) (PEG) with Poly (vinyl chloride) (PVC) with different PEG molecular weights (400 and 4000 g/mol) and PVC via a dry/wet spinning process. In the spinning process, the effects of air gap, wind-up speed, dope extrusion rate, and bore extrusion rate were examined. In addition, the different lengths of the center tube, which acted as the inner-side fiber diameter during the preparation of hollow-fiber membranes, were studied. This research was investigated in order to observe the morphological, dielectric, and dynamic mechanical thermal properties to identify a suitable preparation of a hollow-fiber membrane for feasible applications. The morphology of the PVC-580 blended PEG-400 5 weight percent hollow-fiber membrane was seen to have a dense skin on both the inner and outer fiber surface, along with a suitable dope viscosity. Moreover, it offered finger-like substructures that could provide a high applicable feed-stream permeability and selectivity. Finger-like substructures were present on the near inner fiber surface at the controlled center-tube length of 0.3 cm, more so than at the center tube of 1 cm. This was because the solvent and non-solvent in the lumen tube exchanged more quickly than they did in the coagulant bath. The effect of the wind-up speed during the spinning process was significantly influenced by an affordable hollow fiber that can be indicated by the drawing ratio (λ). It was found that the drawing ratio of 3.3 showed a thickness thinner than 2.6 and 2.0, respectively. In summary, a controlled wind-up speed, an acceptable dope viscosity, and—most importantly—an agglomerated time resulted in membrane preparation.
Brown Algae as a Valuable Substrate for the Cost-Effective Production of Poly-γ-Glutamic Acid for Applications in Cream Formulations
Authors: Parati Mattia , Philip Catherine , Allinson Sarah L. , Mendrek Barbara , Khalil Ibrahim , Tchuenbou-Magaia Fideline , Kowalczuk Marek , Adamus Grazyna , Radecka Iza
Published: July 2024

Poly-γ-glutamic acid (γ-PGA) is a carboxylic-acid-rich, bio-derived, water-soluble, edible, hydrating, non-immunogenic polymer produced naturally by several microorganisms. Here, we re-emphasise the ability of Bacillus subtilis natto to naturally produce γ-PGA on whole seaweed, as well as for the yields and chemical properties of the material to be affected by the presence of Mn(2+). Hyaluronic acid (HA) is an extracellular glycosaminoglycan which presents a high concentration of carboxylic acid and hydroxyl groups, being key in fulfilling numerous applications. Currently, there are strong environmental (solvent use), social (non-vegan extraction), and economic factors pushing for the biosynthesis of this material through prokaryotic microorganisms, which is not yet scalable or sustainable. Our study aimed to investigate an innovative raw material which can combine both superior hygroscopicity and UV protection to the cosmetic industry. Comparable hydration effect of commercially available γ-PGA to conventional moisturising agents (HA and glycerol) was observed; however, greater hydration capacity was observed from seaweed-derived γ-PGA. Herewith, successful incorporation of seaweed-derived γ-PGA (0.2–2 w/v%) was achieved for several model cream systems with absorbances reported at 300 and 400 nm. All γ-PGA-based creams displayed shear thinning behaviour as the viscosity decreased, following increasing shear rates. Although the use of commercial γ-PGA within creams did not suggest a significant effect in rheological behaviour, this was confirmed to be a result of the similar molecular weight. Seaweed-derived γ-PGA cream systems did not display any negative effect on model HaCaT keratinocytes by means of in vitro MTT analysis.
CACM-Net: Daytime Cloud Mask for AGRI Onboard the FY-4A Satellite
Authors: Yang Jingyuan , Qiu Zhongfeng , Zhao Dongzhi , Song Biao , Liu Jiayu , Wang Yu , Liao Kuo , Li Kailin
Published: July 2024

Accurate cloud detection is a crucial initial stage in optical satellite remote sensing. In this study, a daytime cloud mask model is proposed for the Advanced Geostationary Radiation Imager (AGRI) onboard the Fengyun 4A (FY-4A) satellite based on a deep learning approach. The model, named “Convolutional and Attention-based Cloud Mask Net (CACM-Net)”, was trained using the 2021 dataset with CALIPSO data as the truth value. Two CACM-Net models were trained based on a satellite zenith angle (SZA) < 70° and >70°, respectively. The study evaluated the National Satellite Meteorological Center (NSMC) cloud mask product and compared it with the method established in this paper. The results indicate that CACM-Net outperforms the NSMC cloud mask product overall. Specifically, in the SZA < 70° subset, CACM-Net enhances accuracy, precision, and F1 score by 4.8%, 7.3%, and 3.6%, respectively, while reducing the false alarm rate (FAR) by approximately 7.3%. In the SZA > 70° section, improvements of 12.2%, 19.5%, and 8% in accuracy, precision, and F1 score, respectively, were observed, with a 19.5% reduction in FAR compared to NSMC. An independent validation dataset for January–June 2023 further validates the performance of CACM-Net. The results show improvements of 3.5%, 2.2%, and 2.8% in accuracy, precision, and F1 scores for SZA < 70° and 7.8%, 11.3%, and 4.8% for SZA > 70°, respectively, along with reductions in FAR. Cross-comparison with other satellite cloud mask products reveals high levels of agreement, with 88.6% and 86.3% matching results with the MODIS and Himawari-9 products, respectively. These results confirm the reliability of the CACM-Net cloud mask model, which can produce stable and high-quality FY-4A AGRI cloud mask results.
Wet-ConViT: A Hybrid Convolutional–Transformer Model for Efficient Wetland Classification Using Satellite Data
Authors: Radman Ali , Mohammadimanesh Fariba , Mahdianpari Masoud
Published: July 2024

Accurate and efficient classification of wetlands, as one of the most valuable ecological resources, using satellite remote sensing data is essential for effective environmental monitoring and sustainable land management. Deep learning models have recently shown significant promise for identifying wetland land cover; however, they are mostly constrained in practical issues regarding efficiency while gaining high accuracy with limited training ground truth samples. To address these limitations, in this study, a novel deep learning model, namely Wet-ConViT, is designed for the precise mapping of wetlands using multi-source satellite data, combining the strengths of multispectral Sentinel-2 and SAR Sentinel-1 datasets. Both capturing local information of convolution and the long-range feature extraction capabilities of transformers are considered within the proposed architecture. Specifically, the key to Wet-ConViT’s foundation is the multi-head convolutional attention (MHCA) module that integrates convolutional operations into a transformer attention mechanism. By leveraging convolutions, MHCA optimizes the efficiency of the original transformer self-attention mechanism. This resulted in high-precision land cover classification accuracy with a minimal computational complexity compared with other state-of-the-art models, including two convolutional neural networks (CNNs), two transformers, and two hybrid CNN–transformer models. In particular, Wet-ConViT demonstrated superior performance for classifying land cover with approximately 95% overall accuracy metrics, excelling the next best model, hybrid CoAtNet, by about 2%. The results highlighted the proposed architecture’s high precision and efficiency in terms of parameters, memory usage, and processing time. Wet-ConViT could be useful for practical wetland mapping tasks, where precision and computational efficiency are paramount.
Multi-Tier Land Use and Land Cover Mapping Framework and Its Application in Urbanization Analysis in Three African Countries
Authors: Shah Heydari Shahriar , Vogeler Jody C. , Cardenas-Ritzert Orion S. E. , Filippelli Steven K. , McHale Melissa , Laituri Melinda
Published: July 2024

The population of Africa is expected to rise to 2.5 billion by 2050, with more than 80% of this increase concentrated in cities. Africa’s anticipated population growth has serious implications for urban resource utilization and management, necessitating multi-level monitoring efforts that can inform planning and decision-making. Commonly, broad extent (e.g., country level) urban change analyses only examine a homogenous “developed” or “built-up” area, which may not capture patterns influenced by the heterogeneity of landscape features within urban areas. Contrarily, studies examining landscape heterogeneity at a finer resolution are typically limited in spatial extent (e.g., single city level). The goal of this study was to develop and test a hierarchical integrated mapping framework using globally available Earth Observation data (e.g., Landsat, Sentinel-2, Sentinel-1, and nightlight imagery) and accessible methodologies to produce national-level land use (LU) and urban-level land cover (LC) map products which may support a range of global and local monitoring and planning initiatives. We test our multi-tier methodology across three rapidly urbanizing African countries for the 2016–2020 period: Ethiopia, Nigeria, and South Africa. The initial output of our methodology includes annual national land use maps (Tier 1) for the purpose of delineating the dynamic boundaries of individual urban areas and monitoring national LU change. To complement Tier 1 LU maps, we detailed urban heterogeneity through LC classifications within urban areas (Tier 2) delineated using Tier 1 LU maps. Based on country-optimized sets of selected features that leverage spatial/texture and temporal dimensions of available data, we obtained an overall map accuracy of between 65 and 80% for Tier 1 maps and between 60 and 80% for Tier 2 maps, dependent on the evaluation country, although with consistent performance across study years providing a solid foundation for monitoring changes. We demonstrate the potential applications for our products through various analyses, including urbanization-driven LU change, and examine LC urban patterns across the three African study countries. While our findings allude to general differences in urban patterns across national scales, further analyses are needed to better understand the complex drivers behind urban LC configurations and their change patterns across different countries, city sizes, and rates of urbanization. Our multi-tier mapping framework is a viable strategy for producing harmonious, multi-level LULC products in developing countries using publicly available data and methodologies, which can serve as a basis for a wide range of informative and insightful monitoring analyses.
Effects of Assimilating Ground-Based Microwave Radiometer and FY-3D MWTS-2/MWHS-2 Data in Precipitation Forecasting
Authors: Wang Bingli , Cheng Wei , Bao Yansong , Wang Shudong , Petropoulos George P. , Fan Shuiyong , Mao Jiajia , Jin Ziqi , Yang Zihui
Published: July 2024

This study investigates the impacts of the joint assimilation of ground-based microwave radiometer (MWR) and FY-3D microwave sounder (MWTS-2/MWHS-2) observations on the analyses and forecasts for precipitation forecast. Based on the weather research and forecasting data assimilation (WRFDA) system, four experiments are conducted in this study, concerning a heavy precipitation event in Beijing on 2 July 2021, and 10-day batch experiments were also conducted. The key study findings include the following: (1) Both ground-based microwave radiometer and MWTS-2/MWHS-2 data contribute to improvements in the initial fields of the model, leading to appropriate adjustments in the thermal structure of the model. (2) The forecast fields of the experiments assimilating ground-based microwave radiometer and MWTS-2/MWHS-2 data show temperature and humidity performances closer to the true fields compared with the control experiment. (3) Separate assimilation of two types of microwave radiometer data can improve precipitation forecasts, while joint assimilation provides the most accurate forecasts among all the experiments. In the single-case, compared with the control experiment, the individual and combined assimilation of MWR and MWTS-2/MWHS-2 improves the six-hour cumulative precipitation threat score (TS) at the 25 mm level by 57.1%, 28.9%, and 38.2%, respectively. The combined assimilation also improves the scores at the 50 mm level by 54.4%, whereas individual assimilations show a decrease in performance. In the batch experiments, the MWR_FY experiment’s TS of 24 h precipitation forecast improves 28.5% at 10 mm and 330% at 25 mm based on the CTRL.
Monitoring Daily Sleep, Mood, and Affect Using Digital Technologies and Wearables: A Systematic Review
Authors: Hickman Robert , D’Oliveira Teresa C. , Davies Ashleigh , Shergill Sukhi
Published: July 2024

Background: Sleep and affective states are closely intertwined. Nevertheless, previous methods to evaluate sleep-affect associations have been limited by poor ecological validity, with a few studies examining temporal or dynamic interactions in naturalistic settings. Objectives: First, to update and integrate evidence from studies investigating the reciprocal relationship between daily sleep and affective phenomena (mood, affect, and emotions) through ambulatory and prospective monitoring. Second, to evaluate differential patterns based on age, affective disorder diagnosis (bipolar, depression, and anxiety), and shift work patterns on day-to-day sleep-emotion dyads. Third, to summarise the use of wearables, actigraphy, and digital tools in assessing longitudinal sleep-affect associations. Method: A comprehensive PRISMA-compliant systematic review was conducted through the EMBASE, Ovid MEDLINE(R), PsycINFO, and Scopus databases. Results: Of the 3024 records screened, 121 studies were included. Bidirectionality of sleep-affect associations was found (in general) across affective disorders (bipolar, depression, and anxiety), shift workers, and healthy participants representing a range of age groups. However, findings were influenced by the sleep indices and affective dimensions operationalised, sampling resolution, time of day effects, and diagnostic status. Conclusions: Sleep disturbances, especially poorer sleep quality and truncated sleep duration, were consistently found to influence positive and negative affective experiences. Sleep was more often a stronger predictor of subsequent daytime affect than vice versa. The strength and magnitude of sleep-affect associations were more robust for subjective (self-reported) sleep parameters compared to objective (actigraphic) sleep parameters.
Design and Performance Analysis of Compact Printed Ridge Gap Waveguide Phase Shifters for Millimeter-Wave Systems
Authors: Alathbah Moath , El-Gendy Mohamed S. , Gadelrab Mahmoud , Ali Mohamed Mamdouh M.
Published: July 2024

This paper introduces compact Printed Ridge Gap Waveguide (PRGW) phase shifters tailored for millimeter-wave applications, with a focus on achieving wide operating bandwidth, and improved matching and phase balance compared to single-layer technology. This study proposes a unique approach to achieve the required phase shift in PRGW technology, which has not been previously explored. This study also introduces a novel analytical approach to calculate the cutoff frequency and propagation constant of the PRGW structure, a method not previously addressed. Furthermore, the utilization of multi-layer PRGW technology enables the realization of multi-layer beamforming networks without crossing, thereby supporting wideband operation in a compact size. The proposed design procedure enables the realization of various phase shift values ranging from 0∘ to 135∘ over a broad frequency bandwidth centered at 30 GHz. A 45-degree phase shifter is fabricated and tested, demonstrating a 10 GHz bandwidth (approximately 33% fractional bandwidth) from 25 GHz to 35 GHz. Throughout the operating bandwidth, the phase balance remains within 45 ± 5∘, with a deep matching level of −20 dB. The proposed phase shifter exhibits desirable characteristics, such as compactness, low loss, and low dispersion, making it a suitable choice for millimeter-wave applications, including beyond 5G (B5G) and 6G wireless communications.
Compact Spatial Heterodyne Spectrographs for Future Space-Based Observations: Instrument Modeling and Applications
Authors: Sahoo Ayan , Mathew Joice , Battisti Andrew , Tucker Brad
Published: July 2024

High-resolution spectroscopy employing spatial heterodyne spectrographs (SHS) holds significant promise for forthcoming space missions, building upon its established track record in science applications. Notably, it offers exceptional performance and cost- effectiveness in the ultraviolet-visual (UV-Vis) region compared to contemporary instruments. SHS instruments provide high-resolution capabilities and substantially larger etendues than similar resolving power instruments. This study introduces a comprehensive Python-based SHS model integrated with a user-friendly web scraping interface for target star selection, parameter generation, and 2D interferogram creation. Our SHS model demonstrates double the resolving power of a grating spectrometer and a throughput comparable to a Fourier transform spectrometer (FTS) but without moving parts, enhancing robustness for deployment in space. The interferogram processing algorithm includes flat-fielding, bias removal, apodization, and an inverse Fourier transform (IFT) for accurate spectrum retrieval. Despite bandwidth limitations due to resolving power constraints, SHS models excel in applications requiring high spectral resolution over narrow wavelength ranges, such as studying isotopic emission lines. The model provides optimization results and trade-offs for system parameters, ensuring precise spectral recovery with realistic signal-to-noise ratio (SNR) values. SHS is versatile and effective for various scientific applications, including investigating atomic and molecular emissions from comets, planetary atmospheres, the Earth’s atmosphere, the Sun, and the interstellar medium (ISM). This research significantly contributes to expediting the development and deployment of SHS instruments, demonstrating their potential across numerous scientific domains.
Overarm Training Tolerance: A Pilot Study on the Use of Muscle Oxygen Saturation as a Biomarker
Authors: Gorti Bhargav , Stephenson Connor , Sethi Maia , Gross KaiLi , Ramos Mikaela , Seshadri Dhruv , Drummond Colin K.
Published: July 2024

Ulnar collateral ligament (UCL) tears occur due to the prolonged exposure and overworking of joint stresses, resulting in decreased strength in the flexion and extension of the elbow. Current rehabilitation approaches for UCL tears involve subjective assessments (pain scales) and objective measures such as monitoring joint angles and range of motion. The main goal of this study is to find out if using wearable near-infrared spectroscopy technology can help measure digital biomarkers like muscle oxygen levels and heart rate. These measurements could then be applied to athletes who have been injured. Specifically, measuring muscle oxygen levels will help us understand how well the muscles are using oxygen. This can indicate improvements in how the muscles are healing and growing new blood vessels after reconstructive surgery. Previous research studies demonstrated that there remains an unmet clinical need to measure biomarkers to provide continuous, internal data on muscle physiology during the rehabilitation process. This study’s findings can benefit team physicians, sports scientists, athletic trainers, and athletes in the identification of biomarkers to assist in clinical decisions for optimizing training regimens for athletes that perform overarm movements; the research suggests pathways for possible earlier detection, and thus earlier intervention for injury prevention.
Network Security Prediction of Industrial Control Based on Projection Equalization Optimization Algorithm
Authors: Li Guoxing , Wang Yuhe , Li Shiming , Yang Chao , Yang Qingqing , Yuan Yanbin
Published: July 2024

This paper predicts the network security posture of an ICS, focusing on the reliability of Industrial Control Systems (ICSs). Evidence reasoning (ER) and belief rule base (BRB) techniques are employed to establish an ICS network security posture prediction model, ensuring the secure operation and prediction of the ICS. This model first integrates various information from the ICS to determine its network security posture value. Subsequently, through ER iteration, information fusion occurs and serves as an input for the BRB prediction model, which necessitates initial parameter setting by relevant experts. External factors may influence the experts’ predictions; therefore, this paper proposes the Projection Equalization Optimization (P-EO) algorithm. This optimization algorithm updates the initial parameters to enhance the prediction of the ICS network security posture through the model. Finally, industrial datasets are used as experimental data to improve the credibility of the prediction experiments and validate the model’s predictive performance in the ICS. Compared with other methods, this paper’s prediction model demonstrates a superior prediction accuracy. By further comparing with other algorithms, this paper has a certain advantage when using less historical data to make predictions.