bluuebunny/crossref_metadata_2025 huggingface dataset:
Dietary marine hydrolysate alleviates D-galactose-induced brain aging by attenuating cognitive alterations, oxidative stress and inflammation through the AGE-RAGE axis
Authors: Mougin Camille , Chataigner Mathilde , Lucas Céline , Pallet Véronique , Bouvret Elodie , Joffre Corinne , Dinel Anne-Laure
Published: October 2024

Aging represents a natural and unavoidable phenomenon in organisms. With the acceleration of population aging, investigations into aging have garnered widespread global interest. One of the most striking aspects of human aging is the decline in brain function, a phenomenon intricately tied to the onset of neurodegenerative conditions. This study aimed to assess the impact of a fish hydrolysate, rich in low-molecular-weight peptides and n-3 LC-PUFAs, on cognitive function, inflammatory response, and oxidative stress via the AGE-RAGE axis in a mouse model of accelerated aging. This model induces cognitive decline and biochemical alterations akin to those observed during natural aging. The findings revealed that fish hydrolysate exhibited a protective effect against cognitive impairment induced by D-galactose. This effect was associated with increased protein expression of SOD1 and decreased genetic expression of IL-6 and advanced glycation end products (AGE). Consequently, within the realm of preventive and personalized nutrition, fish hydrolysate emerges as a promising avenue for mitigating age-related declines in memory function.
Vascular access devices and associated complications in paediatric critical care: A prospective cohort study
Authors: Gaetani Melany , Kleiboer Sarah , Kissoon Randolph , Middaugh Kristen , Parshuram Christopher S.
Published: October 2024

Background

Though 60–80% of hospitalized patients have an intravascular device placed during hospitalization, there is a substantial risk of complication related to the placement, maintenance and removal of these devices. The objectives of this study were to describe vascular access device use, device complications and lumen dysfunction.

Methods

An observational cohort study was conducted over a 4.5 years period, in two quaternary, university-affiliated paediatric intensive care units (ICU). Eligible patients were admitted to either the paediatric or cardiac ICU and had one or more vascular access devices in-situ at the time of enrolment. Vascular access devices were defined as any external connection directly into the circulation including peripheral and central veins, arteries or bone marrow. Consistent with practice in the studied ICUs removal of peripheral catheters was regarded as due to dysfunction or complication.

Results

220 patients, 683 devices and 924 lumens were observed. The device complication rate was 21% and the lumen complication rate was 25%. The median duration without complication was 18 days for arterial catheters, 14 days for central venous catheters; 13 days for peripherally inserted central catheters and 4 days for peripheral intravenous catheters. On one third of all patient days, the volume of fluid administered to maintain VADs was equal to or greater than 20% of the total hourly total fluid intake.

Conclusion

Approximately 1 in 5 vascular devices had one or more complications in ICU, most devices continued to be used without removal, and some complications resolved. The implications of the fluids infused to maintain device function warrants further study, as do strategies to resolve or limit the their complications in children.
Energy use and its contributors in hotel buildings: A systematic review and meta-analysis
Authors: Arenhart Rodrigo Schons , Martins Tailon , Ueda Renan Mitsuo , Souza Adriano Mendonça , Zanini Roselaine Ruviaro
Published: October 2024

Energy use is the major source of carbon emissions in hotel buildings. Past studies presented contributors to energy use, most related to hotels’ physical and economics characteristics. In search of effective variables affecting energy use in hotels, this systematic review and meta-analysis aims to synthesize empirical evidence. A descriptive picture of 28 previous studies, the arguments for the direction of effects in each variable, and a quantitative synthesis of the mean effect sizes were presented. Among 18 selected contributors from past studies, 15 were statistically significant (0.05 level). The analyses also revealed that the operationalization of the energy variable is important in evaluating the relationship with a contributor. Studies considering Energy Use Intensity (EUI) indicators presented weaker correlations with gross floor area (GFA) and number of guestrooms than those considering energy raw data, for example. The occupancy rate resulted in a non-significant outcome, but this result could be related to differences among the hotels categories, as identified in the subgroup and meta-regression analyses. Future research could help develop and investigate theories to sustain or deny the relationships found here, in addition to the assessment of the outcomes in other regions, bringing more variables related to sustainable management.
The sustainability effects of two reading interventions on Saudi nursing students’ comprehension of scientific research
Authors: Al-Moteri Modi , Alqarni Ibrahim R. , Elryah Ahmed AbdElbagy Ibrahim , Plummer Virginia , Almalki Mohammed
Published: October 2024

Background

Scientific literature is presented in complex language, most frequently in English, and includes technical jargon that represents a challenge to comprehension of an English as a foreign language (EFL) nursing student. Yet scientific literature is a powerful and trustworthy source of evidence to guide nursing practice.

Purpose

The aim is to examine two reading interventions (Translation vs Synthesization) and to determine which one produces long-term sustainability effects in scientific research reading comprehension.

Method

A two-group posttest-only randomized comparative design was used in which 120 participants were randomly assigned to two groups. Several instruments were used to collect the data.

Results

Study findings showed that the synthesization group significantly produced better results when compared with the translation group on both the immediate (p = 0.01) and the delayed (p = 0.013) reading comprehension tests. It shows also that gender differences have a significant impact on reading comprehension with a favor to males in the long-term reading comprehension outcome (p = 0.038) of synthesization and females in the short-term reading comprehension outcome (p = 0.015) of translation. English proficiency was significant with determination, metacognitive, and social skills in the synthesization group (p = 0.00, p = 0.01, p = 0.007 respectively).

Conclusion

The results suggested that synthesization could be an effective reading approach in improving EFL nursing students’ reading comprehension of scientific literature.
Study on the enhancement of low carbon-to-nitrogen ratio urban wastewater pollutant removal efficiency by adding sulfur electron acceptors
Authors: Luo Erming , Ouyang Jia , Zhang Xinxin , Lu Qian , Wei Dong , Wang Yongcheng , Cha Zhengjiong , Ye Chengwei , Li Chun ying , Wei Li
Published: October 2024

The effective elimination of nitrogen and phosphorus in urban sewage treatment was always hindered by the deficiency of organic carbon in the low C/N ratio wastewater. To overcome this organic-dependent barrier and investigate community changes after sulfur electron addition. In this study, we conducted a simulated urban wastewater treatment plant (WWTP) bioreactor by using sodium sulfate as an electron acceptor to explore the removal efficiency of characteristic pollutants before and after the addition of sulfur electron acceptor. In the actual operation of 90 days, the removal rate of sulfur electrons’ chemical oxygen demand (COD), ammonia nitrogen, and total phosphorus (TP) with sulfur electrons increased to 94.0%, 92.1% and 74%, respectively, compared with before the addition of sulfur electron acceptor. Compared with no added sulfur(phase I), the reactor after adding sulfur electron acceptor(phase II) was demonstrated more robust in nitrogen removal in the case of low C/N influent. the effluent ammonia nitrogen concentration of the aerobic reactor in Pahse II was kept lower than 1.844 mg N / L after day 40 and the overall concentration of total phosphorus in phase II (0.35 mg P/L) was lower than that of phase I(0.76 mg P/L). The microbial community analysis indicates that Rhodanobacter, Bacteroidetes, and Thiobacillus, which were the predominant bacteria in the reactor, may play a crucial role in inorganic nitrogen removal, complex organic degradation, and autotrophic denitrification under the stress of low carbon and nitrogen ratios. This leads to the formation of a distinctive microbial community structure influenced by the sulfur electron receptor and its composition. This study contributes to further development of urban low-carbon-nitrogen ratio wastewater efficient and low-cost wastewater treatment technology.
Spatial analyses of archaeobotanical record reveal site uses and activities at Early to Middle Holocene Takarkori (Libya, Central Sahara)
Authors: di Lernia Savino , Buldrini Fabrizio , Florenzano Assunta , Mercuri Anna Maria , Nardi Varinia , Rotunno Rocco
Published: October 2024

This study investigates botanical remains from the Takarkori site in the Tadrart Acacus region (SW Libya) to reconstruct socio-economic and cultural characteristics of human groups during the Holocene. By analyzing micro- and macrofossils of plant origin, we aim to understand the availability and management of environmental resources and how plant taxa were used by humans. The exceptional preservation of archaeobotanical material across all occupation levels, facilitated by the region’s geomorphological and environmental conditions, provides a unique opportunity to study pre-Pastoral and Pastoral Neolithic activities within a comprehensive diachronic framework. Our research extends previous investigations by examining the spatial distribution of archaeobotanical remains in association with site furniture and material correlates, offering insights into the functional use of space within the site. Also, the features of plant assemblages and their distribution patterns indicate the planning in the use of plant resources and the diverse uses beyond subsistence, including ritual and cultural practices. The findings contribute to a deeper understanding of Holocene environmental and cultural dynamics, highlighting the importance of archaeobotanical data in archaeological research.
An analysis of production efficiency in China’s real estate industry based on a two-stage DEA model
Authors: Meng Jiening , Bu Wei
Published: October 2024

To examine the resource utilization in different phases such as development and sales within China’s real estate industry, this paper employs a two-stage Data Envelopment Analysis (DEA) model to measure the production efficiency of the real estate industry across 31 provinces, municipalities, and autonomous regions of China from 2014 to 2022. By examining both overall and phase-specific trends, the study utilizes a panel Tobit model to explore the factors affecting efficiency. Empirical results indicate that the leverage ratio of companies, per capita GDP of regions, and real estate regulatory policies significantly impact production efficiency. Further analysis of regional heterogeneity and its effect on production efficiency revealed that the per capita residential building area, which reflects the housing stock configuration in different regions, exhibits a significant single threshold effect. This not only objectively assesses the utilization of real estate resources in different areas but also delves deeper into the principal factors and their mechanisms affecting the production efficiency of the real estate industry, thus providing theoretical support and policy recommendations for effectively enhancing production efficiency.
The impact of the digital economy on food system resilience: Evidence from China
Authors: Zhu Zheng , Wang Zhen , Yu Song , Tang Zhaomei , Liu Bin
Published: October 2024

Despite the widespread influence of the burgeoning digital economy on agricultural productivity in recent years, China’s food system confronts numerous challenges. Notably, research exploring the digital economy’s impact on food system resilience remains scarce, and the pivotal role of industrial agglomeration in this context remains unclear. Therefore, this article is based on the panel data of 30 provinces in China from 2011 to 2021, this paper empirically examines the direct effect, the mechanism of action, and the spatial spillover effect of the resilience of a digital economy-enabled food system using a double fixed-effects model, mediated-effects model, and spatial econometric model. The results show the following: (1) The resilience of China’s urban food system shows obvious spatial differences, but the overall trend in improvement requires attention. (2) The development of a digital economy has a facilitating effect on the level of resilience of the food system, and industrial agglomeration induces an intermediary effect. (3) The digital economy has a significant positive spatial spillover effect on the resilience of the food system; i.e., the digital economy can improve the resilience of the food system in the region and the neighboring regions. Accordingly, policy recommendations have been put forward to improve infrastructure construction and promote the development of digital villages; strengthen the construction of industrial agglomerations and promote the enhancement of the quality and efficiency of industries; and promote the development of regional linkages and build a solid foundation for food security.
Construction and practice of a novel pharmaceutical health literacy intervention model in psychiatric hospital
Authors: Qiu Linghe , Li Jun , Xie Weiming , Wang Fei , Shen Yuan , Wu Jianhong
Published: October 2024

Objective

Pharmaceutical health literacy intervention (PHLI) plays a crucial role in influencing patients’ medical decision-making, particularly concerning medication use. However, PHLI has not been widely implemented in China. This study aims to develop a novel PHLI model within a psychiatric hospital setting and evaluate its effectiveness.

Methods

A PHLI model encompassing four modes—covering inpatients, outpatients, Internet+ and community—was established at The Affiliated Mental Health Center of Jiangnan University. The model’s operation was detailed, and its performance data from 2022 and 2023 were evaluated.

Results

In 2022 and 2023, a total of 636 PHLI cases were reported. Of these, 386 cases (60.69%) were identified through the inpatient mode. The proportion of PHLI delivered via inpatient and Internet information subscription modes gradually increased, while interventions through other methods decreased. The age group of 18–30 accounted for 21.97% of cases, with 116 instances reported. Various types of PHLI were provided, including adverse reactions (18.87%), dosage and administration (11.64%), and therapeutic drug monitoring (9.43%). In addition, intervention strategies primarily focused on adverse reaction identification (10.22%), interpretation of pharmaceutical reports (7.23%), and routine examination reminders (6.45%).

Conclusion

The PHLI model developed at our hospital offers an effective approach to health literacy intervention and represents an innovation advancement in pharmaceutical health literacy management. It can also serve as a reference framework for other hospitals.
Applied research on the design of protective clothing based on the Kano-QFD-PUGH method
Authors: Li Hong , Shi Li
Published: October 2024

In order to improve the user experience of protective clothing for healthcare workers and reduce the design blindness and subjectivity of developers, we propose a research methodology that combines the Kano model, QFD quality function deployment, and PUGH decision-making scheme to develop conceptual solutions for medical protective clothing design. Firstly, we use the Kano model to identify the user requirements of healthcare workers and construct a hierarchy of functional requirements for protective clothing. Secondly, we use the QFD method to weigh the protective clothing design elements, convert user requirements into design elements, establish a relationship matrix between user requirements and design elements, and generate four conceptual design solutions based on the results. Finally, we use the PUGH decision-making method to filter and select the best concept solution for protective clothing design, and validate the design evaluation. Our results show that the protective clothing solutions designed using the combined Kano-QFD-PUGH system approach have a higher level of satisfaction compared to traditional protective clothing design. This method accurately explores the mapping relationship between user requirements and design functional elements and can be used as a general reliability design method. It helps to improve the development efficiency of designers and the decision-making role for design concept solution preference. Overall, our research methodology provides a comprehensive approach to developing medical protective clothing, which can be useful for designers and decision-makers in the healthcare industry.
Small-cell carcinoma in the head and neck region: A propensity score-matched analysis of the effect of surgery
Authors: Hosokawa Kiyohito , Takenaka Yukinori , Sato Takashi , Tsuda Takeshi , Eguchi Hirotaka , Suzuki Masami , Kitamura Koji , Fukusumi Takahito , Suzuki Motoyuki , Inohara Hidenori
Published: October 2024

Background

Head and neck small-cell carcinoma (HNSmCC) is a rare and aggressive cancer with a high tendency for distant metastasis. It is treated with multimodal treatment involving chemotherapy. Occasionally, surgery is performed for the management of locoregional HNSmCC. However, the benefits of surgery in this context have not yet been elucidated. Therefore, in this study, we aimed to investigate whether surgery could improve the survival of patients with HNSmCC.

Patients and methods

We obtained data from patients with locoregional HNSmCC treated with chemoradiation therapy (CRT) from the Surveillance, Epidemiology, and End Results database. Patients who did and did not undergo surgery were matched using propensity scores. The overall survival (OS) and disease-specific survival (DSS) rates were estimated using the Kaplan-Meier method and tested using the log-rank test. Hazard ratios (HRs) were calculated using the Cox proportional hazard model.

Results

The 5-year OS rates of the patients who did and did not undergo surgery were 57.2% and 50.6%, respectively (P = 0.689); the corresponding 5-year DSS rates were 61.0% and 57.5% (P = 0.769). The adjusted HRs for surgery were 0.85 (95% confidence interval [CI]: 0.54–1.33) for OS and 0.87 (95% CI: 0.51–1.49) for DSS.

Conclusion

The addition of surgery to CRT did not improve the survival of patients with locoregional HNSmCC.
Sustainable logistics development strategy based on SWOT and analytic hierarchy process
Authors: Xiao Changgang
Published: October 2024

Due to the implementation of sustainable green development strategy, the study uses the competitive situation method and analytical hierarchy process of logistics enterprises to conduct structural analysis and weight calculation of factor indicators for their development strategies. Afterwards, the exponential smoothing prediction method was used to weight the logistics data. Moreover, through comparative analysis of the indicator evaluation system, the average weights of the advantageous factors of logistics enterprises were found to be 0.0232, 0.1102, 0.0522, and 0.0468, respectively. The energy consumption, transportation volume, and turnover of logistics transportation increased by 68.9% and 52.3% in 2022, respectively, which had a significant impact on the sustainable development of the logistics industry. It has been demonstrated that a sustainable logistics development strategy based on the enterprise competitive situation method and the analytic hierarchy process is both feasible and superior. Furthermore, this strategy has the potential to enhance the environmental benefits and green development of the economy and society.
Kidney protection strategy lowers the risk of contrast-associated acute kidney injury
Authors: Jong Chien-Boon , Kuo Jui-Cheng , Lin I-Chuan
Published: October 2024

We developed a comprehensive kidney protection strategy (KPS), which comprises left ventricular end-diastolic pressure-guided saline hydration, ultralow contrast coronary angiography, and a staged coronary revascularization procedure under suitable conditions. This study aimed to investigate KPS’s effect on the risk of developing contrast-associated acute kidney injury (CA-AKI) among persons with moderate-to-advanced kidney insufficiency (KI). Seventy patients who had undergone cardiac catheterization with an estimated glomerular filtration rate (eGFR) of 15–45 mL/min/1.73 m2 were investigated retrospectively. Among these, 19 patients who had received KPS and 51 who had undergone cardiac catheterization with usual care (UC) were enrolled. CA-AKI was defined as a 0.3-mg/dL increase in serum creatinine levels or dialysis initiation within 72 h after contrast exposure. The inverse probability of treatment weighting (IPTW)-adjusted cohort was analyzed according to the Mehran 2 risk categories. Patients’ mean age was 73.3 ± 9.6 years; mean eGFR was 29.8 ± 8.5 mL/min/1.73 m2; and median of Mehran 2 risk score, 8. Most patients presented with acute myocardial infarction (AMI) or heart failure, and one-fifth of the administered cardiac catheterizations were emergency procedures. After the IPTW adjustment, the KPS group showed a significantly lower CA-AKI risk than the UC group (4% vs. 20.4%; odds ratio 0.19, 95% confidence interval 0.05–0.66). This effect was consistent across various subgroups according to different variables, including old age, AMI, advanced KI, high-risk category, left ventricular systolic dysfunction, and multivessel disease. Conclusively, KPS may reduce the CA-AKI risk in high-risk patients with moderate-to-advanced KI who have undergone cardiac catheterization.
Economic empowerment through Kaaps
Authors: van der Rheede Christo
Published: October 2024

As a regional variety, Kaaps can be seen as a driver of social, cultural, educational and economic interaction in specific contexts. However, the economic value of Kaaps and its role in economic empowerment in these contexts have not yet been properly researched. This chapter aims to inspire scholars to do in-depth research on the role that Kaaps already plays in the regional economy, as well as the role it can play as principal driver of many other commercial and artistic projects.
VREDNOST INFORMACIJE PRI SPREJEMANJU ODLOČITEV: PRIMERI UPORABE V PROIZVODNJI IN PREDELAVI MLEKA
Authors: KAVČIČ S.
Published: October 2024

Prispevek poudarja razliko med intuitivnim in sistematičnim pristopom k sprejemanju poslovnih odločitev. Razlaga osnovne elemente in načela, ki so se uveljavili v teoriji analize odločitev in predstavlja nekatere tehnike vključevanja tveganja v proces odločanja kot njegovega ključnega dejavnika. V tem kontekstu osvetljuje teoretični pomen termina vrednost informacije. Hipotetična primera s področja prireje in predelave mleka ponazarjata možnost uporabe prikazanih metod v praksi in nekatere njihove pomanjkljivosti. Na koncu kritično ocenjuje zmogljivost nekaterih močnejših tehnik, ki naj bi premostile opisane probleme.
PREDNOSTI MESEČNE KONTROLE ŠTEVILA SOMATSKIH CELIC POSAMEZNE KRAVE MOLZNICE PRI ZATIRANJU SUBKLINIČNEGA MASTITISA
Authors: MIJOVIČ A. , PENGOV A. , KLOPČIČ M. , ZADNIK T.
Published: October 2024

Slovenski pravilnik o higieni mleka predpisuje, da oddano mleko ne sme v treh mesecih preseči 500.000 somatskih celic/ml. Za zaželjeno število celic, ki naj bi ne bilo višje od 200.000/ml, je potrebno vpeljati kontinuiran program spremljanja zdravja vimena v čredi. Program med drugim predvideva mesečno kontrolo števila somatskih celic posamezne krave molznice. Na podlagi serije rezultatov lahko lažje izključimo dejavnike, ki niso v povezavi s subkliničnim mastitisom, pravočasno odkrivamo kliconosce v čredi in preprečujemo nadaljnje širjenje okužbe, odredimo optimalni čas zdravljenja, boljše učinke, zlasti okužbe s S. aureus, dosežemo s terapijo v obdobju zasušitve, kontinuirano spremljamo uspešnost zdravljenja in učinkovitost zootehniških ukrepov.
ESTIMATION OF HAY ENERGY VALUE WITH A REGRESSION EQUATION
Authors: STEKAR Jasna M. A. , ZAGOŽEN F. , GOLOB A.
Published: October 2024

825 random samples of hay, 655 the first cut and 170 aftergrass, were analysed according to Weende analysis. The results were accounted with the statistical package SPSS so that multiple regessions were calculated for the starch equivalent (SE) and net energy for lactation (NEL) for all samples and separately for the first cut and aftergrass respect. The equations were carried out with the stepwise inculding the separate nutrients. All multiple regression coefficients (R) were very higly significant. For the first cut samples, the estimation of SE on the base of all nutrients was very accurate (R=0.9796, s.e.=1.4502). For the practice, it is sufficient to estimate it with the crude fibre (CF) and crude protein (CP) contents only (R=0.9613, s.e.=1.9861). In the case of estimation of NEL it is necessary to take into account all nutrients (R=0.9429, s.e.=0.1822). It is possible to estimate SE well with all nutrients (R=0.95488, s.e.=0.14164) in afftergrass. For NEL CP, ether extract and nitrogen-free extractives (R=0.93487, s.e.=0.14164) are sufficient. When the samples are not defined, SE and NEL should be estimated with all nutrients (R=0.97186, s.e.=1.69134 resp. R=0.95646, s.e.=0.15974).
SOME ASPECTS ON GMPs IN FOOD INDUSTRY
Authors: BOCKELMANN B. VON
Published: October 2024

Good manufacturing practices (GMPs) intend to safeguard the production of food products thus rendering the operation more effective. GMPs have a very wide scope, including the environment in which the factory is placed, the premises, the building, product flow, management, organisation, equipment, the installation of the equipment, quality control, and quality assurance. Avoidance of unnecessary chemical, physical, and microbiological contamination is possible only if the above factors are considered. Some aspects on above subjects are discussed, including a very short presentation of the HACCP (Hazard Analysis Critical Control Point) concept.
MILCHPRÜFRING BAYERN e.V. – RAW MILK QUALITY CONTROL IN BAVARIA
Authors: BAUMGARTNER C.
Published: October 2024

In Bavaria 79.000 dairy farmers with 1.600.000 cows produce some 7 million tons of raw milk per year. The "Milchprüfring Bayern e.V." performs quality control of raw milk according to German and Bavarian law. This paper provides information about its organisation, obligations and duties. The "Milchprüfring" is a privately initiated organisation of the Bavarian dairy farmers and dairy industry with members out of each group. Budgets are 50% publicly financed, 25% come from the Bavarian dairy fonds and from fees for sample processing, respectively. The "Milchprüfring" runs 4 central labs, equipped with most modern automates for milk analysis. About 200 persons of laboratory and technical staff are performing 10 million investigations for fat, protein, lactose, bacteria, somatic cells, freezing-point and inhibitors. Additionaly 10 million samples per year are investigated for fat, protein, lactose, somatic cells and urea due to performance testing of cows. Automation of all the investigation process from sampling to handling and mailing of results and tight collaboration with scientific instituts make sure, that quality of analysis is constantly high. External technical staff supports states’ veterinary services by visiting farms and controlling conditions according to the hygiene guideline 92/46 EEC, which was set to german law with the "Milchverordnung" of May, 3rd 1995.
Deconstructing the ‘Gandhāra still’: a new challenge to the accepted trajectory of early distillation technology
Authors: Groat Nicholas
Published: October 2024

The ‘Gandhāra still’ has been an influential element in the archaeology of south-central Asia for decades. This project combines archival research, material synthesis and experimental evaluation to reappraise this eminent and pervasive reconstruction, and to systematically dismiss an assumed component in the history of distillation.
Distinct Functional Classes of CA1 Hippocampal Interneurons Are Modulated by Cerebellar Stimulation in a Coordinated Manner
Authors: Froula Jessica M. , Rose Jarrett J. , Krook-Magnuson Chris , Krook-Magnuson Esther
Published: October 2024

There is mounting evidence that the cerebellum impacts hippocampal functioning, but the impact of the cerebellum on hippocampal interneurons remains obscure. Using miniscopes in

freely behaving male and female mice, we found optogenetic stimulation of Purkinje cells alters the calcium activity of a large percentage of CA1 interneurons. This includes both increases and decreases in activity. Remarkably, this bidirectional impact occurs in a coordinated fashion, in line with interneurons’ functional properties. Specifically, CA1 interneurons activated by cerebellar stimulation are commonly locomotion-active, while those inhibited by cerebellar stimulation are commonly rest-active interneurons. We additionally found that subsets of CA1 interneurons show altered activity during object investigations. Importantly, these interneurons also show coordinated modulation by cerebellar stimulation: CA1 interneurons that are activated by cerebellar stimulation are more likely to be activated, rather than inhibited, during object investigations, while interneurons that show decreased activity during cerebellar stimulation show the opposite profile. We examined two different stimulation locations (IV/V vermis or simplex) and two different stimulation approaches (7 Hz or a single 1 s light pulse)—in all cases, the cerebellum induces similar coordinated CA1 interneuron changes congruent with an explorative state. Overall, our data show that CA1 interneurons are impacted by cerebellar manipulation in a bidirectional and coordinated fashion and are therefore likely to play an important role in cerebello–hippocampal communication.
The Link between Food Insecurity and Intimate Partner Violence
Authors: Waterman Emily A. , Abatemarco Tatiana
Published: October 2024

Food insecurity and intimate partner violence (IPV) are important public health issues and are often linked. In this article we describe a series of interviews, aiming for a more detailed understanding of how food insecurity and IPV contour the lives of women in rural Vermont. Interviews highlighted how violence affects eating habits, and the role of other health issues and experiences such as incarceration and substance use. Participants shared their idea of good food, and barriers to good food. While obtaining enough calories and nutrients is important for health, participants spoke about the importance of food as a demonstration of love, care, and bonding. This aspect of eating may be even more critical for IPV survivors, who often experience intense feelings of isolation. Participants also identified community resources, causes of violence, and ideas for prevention.
APPLICATION RECONSTRUCTION METHOD FOR CREATING CONTAINERS OF DISTRIBUTED MICROSERVICE ARCHITECTURE AND TRANSACTIONS BETWEEN THEM
Authors:   Odesa Polytechnic National University, Kupriyanov O. M. , Sytnikov V. S. ,   Odesa Polytechnic National University
Published: October 2024

Abstract. Microservices are small, autonomous services. An application consisting of such microservices can be developed separately, with each microservice processing its own part of the logic without interacting with the others. Microservices are easy to deploy in containers, and container orchestration technologies help manage their distribution and updates. Therefore, many companies are moving from monolithic architectures to microservices. This article describes a method for converting a monolithic application into a microservice architecture of a container-based distributed system. Microservices are defined through data analysis of a monolithic application. It also provides a method for creating templated deployment scripts to support and distribute microservices in a containerized environment. The results of the study confirmed the effectiveness of the proposed approach. A runtime performance evaluation for API calls at various stages of development was conducted, which confirmed the benefits of a microservice architecture. The findings show that microservices created by the proposed method have higher reusability compared to those created by traditional methods. Keywords: container, microservice, API, scalability, distributed system
Painless thyroiditis associated with SARS-CoV-2 and influenza infections in a patient with central hypothyroidism after pituitary surgery
Authors: Wada Norio , Sugawara Hajime , Satoh Ayaka , Baba Shuhei , Miyoshi Arina , Obara Shinji
Published: October 2024

We present the case of a 50-year-old Japanese woman who was transferred to our hospital with a 2-day history of fever, sore throat, and malaise. She was diagnosed with acromegaly 9 months ago while being treated for diabetic ketoacidosis, for which she underwent pituitary surgery. She was diagnosed with hypopituitarism postoperatively and was prescribed hydrocortisone and levothyroxine. Her glycemic control was good on metformin. Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza were positive in the emergency room. Other laboratory findings included thyrotoxicosis (free T3: 9.13 pg/mL; free T4: 3.64 ng/dL; and thyroid-stimulating hormone (TSH): <0.01 μIU/mL) and a high C-reactive protein (CRP) level (3.84 mg/dL). The test for the TSH receptor antibody was negative. She had no apparent goiter and reported no tenderness in response to thyroid palpation. 99m-Technetium scintigraphy revealed decreased tracer uptake. Ultrasonography showed no hypoechoic lesions. Her thyrotoxicosis spontaneously resolved after 6 weeks. Although both anti-thyroglobulin antibody (TgAb) and anti-thyroid peroxidase antibody (TPOAb) were negative 9 months ago, TgAb was positive at admission. The test for TPOAb became positive 6 weeks later. These findings were suggestive of painless thyroiditis. In this patient, painless thyroiditis was believed to be caused by SARS-CoV-2 and influenza infections. Screening tests of thyroid function in patients with viral infections such as SARS-CoV-2 or influenza are recommended, even when thyroid gland pain or tenderness is not observed.

Learning points

We describe a case of painless thyroiditis associated with SARS-CoV-2 and influenza infections.

Although a few cases of painless thyroiditis associated with COVID-19 have been reported, no cases of painless thyroiditis associated with influenza have been reported.

In this case, thyrotoxicosis developed immediately after the viral infection. In addition, tests for anti-thyroglobulin antibody and anti-thyroid peroxidase antibody were negative before the onset of symptoms. Tests for the former became positive at the time of onset of symptoms, whereas tests for the latter became positive several weeks after the onset of symptoms.

Patients with viral infections such as SARS-CoV-2 and influenza, who had no goiter or thyroid tenderness, may develop painless thyroiditis; screening tests for thyroid function are recommended.
Miguel Ángel Bertolami: pionero en ecología del paisaje en la Patagonia árida
Authors: Buzzi Mariana Andrea , Rueter Bárbara Lisa
Published: October 2024

Miguel Ángel Bertolami fue un pionero en la ecología del paisaje en la árida región de la Patagonia argentina. Nacido en 1956 en Coronel Suárez, Buenos Aires, Bertolami se graduó en Ciencias Biológicas en la Universidad Nacional del Sur y se mudó a Comodoro Rivadavia para dedicarse a su pasión por la Patagonia. Inició su carrera investigando la fitosociología y dendrocronología de los arbustos patagónicos, y luego realizó estudios de posgrado en Brasil y Francia, enfocándose en la erosión del suelo y la desertificación. Bertolami jugó un papel clave en el monitoreo y mitigación de la desertificación en la estepa patagónica, advirtiendo sobre los efectos del sobrepastoreo y el cambio climático. Fue pionero en el uso de imágenes satelitales y técnicas de teledetección para estudiar la degradación del paisaje y desarrollar modelos para un manejo sustentable de los campos ganaderos. Además, trabajó estrechamente con los productores locales para instalar estaciones meteorológicas en zonas remotas, recopilando datos cruciales para sus investigaciones. Como profesor en la Universidad Nacional de la Patagonia San Juan Bosco, Bertolami dedicó gran parte de su tiempo a la formación de estudiantes y a la divulgación científica, participando en programas de radio y dirigiendo la revista Naturalia Patagónica. Su trabajo ha dejado un legado significativo en la ecología de la región patagónica, destacándose por su enfoque en la conservación y el manejo sostenible de los recursos naturales en uno de los ecosistemas más frágiles del mundo.
Un retablo con la marca de taller de los Penicaud en el Instututo Valencia de D. Juan
Authors: Martín Ansón María Luisa
Published: October 2024

Anuario del Departamento de Historia y Teoría del Arte
Aportación al estudio de las exequias reales en Hispanoamérica: La influencia sevillana en algunos túmulos limeños y mejicanos
Authors: Allo Manero María Adelaida
Published: October 2024

Anuario del Departamento de Historia y Teoría del Arte
El efecto de referencia disjunta en la historia de la gramática española: el caso de Vicente Salvá (1847)
Authors: Gil de la Puerta Macarena
Published: October 2024

El efecto de referencia disjunta es un fenómeno sintáctico que consiste en que, en algunas oraciones subordinadas sustantivas, como María quiere que estudie, el sujeto del verbo principal no puede correferir con el sujeto del verbo subordinado. Es un fenómeno que se da en lenguas como el español, el italiano, el portugués o el serbio, entre otras, y que suele analizarse desde una perspectiva teórica y sincrónica. En el presente trabajo, sin embargo, lo enfocaremos desde una perspectiva historiográfica: analizaremos cómo el gramático y lexicógrafo valenciano Vicente Salvá lo trata en su obra, Gramática de la lengua castellana según ahora se habla (1847), prestando atención a su contexto, a los aspectos teóricos que imperaban en su tiempo, y a si sus ideas y descripciones sobre el efecto de referencia disjunta pueden seguir considerándose vigentes, o no, en la actualidad.
Todos mis amigos se llaman Cayetano: estudio sobre la lexicalización del antropónimo "Cayetano"
Authors: Méndez Santos María del Carmen , Rey Barona Clara
Published: October 2024

La evolución del léxico de las lenguas deviene de diferentes fenómenos morfológicos, sintácticos, semánticos, etc. En particular, en este trabajo se analiza cómo el antropónimo Cayetano ha seguido un proceso de lexicalización hasta convertirse en un nombre común. Para describir y constatar su evolución se elaboró un corpus de tuits. Asimismo, y para complementar el análisis, se empleó un instrumento cuantitativo de recogida de datos para lograr obtener la opinión de los hablantes de manera directa. El resultado del estudio del corpus y del examen de las respuestas del cuestionario apuntan a que cayetano se comporta como un nombre común puesto que admite concordancia en género y número, modificación de clasificadores e incluso funciona como adjetivo admitiendo gradación. Es más, se han atestiguado derivados y formas compuestas y locuciones. Este proceso se ha producido a través de una prototipización semántica de los aspectos cognitivamente más prominentes.
PHYSICOCHEMICAL STUDIES OF THE HUMIC, HYMATOMELANIC AND FULVIC ACIDS OF BROWN COALS
Authors: VOTOLIN K.S. , ZHEREBTSOV S.I. , SHPAKODRAEV K.M. , MALYSHENKO N.V. , ISMAGILOV Z.R.
Published: October 2024

The procedure for obtaining humic (HA), hymatomelanic (HmA) and fulvic acids (FA) that allows achieving their high yield has been developed and tested with the brown coals of the Kansk-Achinsk and the South Ural basins. The highest yield of humic substances is achieved for naturally oxidized brown coal of the Tisul deposit: HA - 68.0%, HmA - 11.3%, FA - 9.6%. The composition of native brown coals, as well as HA, HmA and FA obtained from them, was studied using proximate and ultimate analysis, FTIR spectroscopy and 13C NMR (CPMAS) spectroscopy. It is established that the chemical and structural-group composition of HA, HmA and FA has significant differences. The samples of HmA and FA are characterized by relatively high content of oxygen-containing aliphatic groups with the predominance of carboxylic acids and esters in comparison with HA. Higher content of carbon, hydrogen and aromatic fragments is characteristic of HA. The samples of HmA and FA have similar elemental and structural group composition, however, HmA has a higher content of carbon and aromatic fragments.
INTEGRATED INVESTIGATION OF THE STRUCTURE OF INDUSTRIAL GREEN COKE
Authors: ZAKHAROV N.S. , SOZINOV S.A. , POPOVA A.N. , ISMAGILOV Z.R.
Published: October 2024

Integrated studies of green coke have been carried out by means of X-ray diffractometry, electron microscopy, electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR). It is determined by EPR spectroscopy that two types of radical structures are present in the samples: low-molecular aromatic radicals and conjugated polyaromatic structures in which the unpaired electron is delocalised. Analysis of line shapes in the EPR spectra reveals differences between the green coke samples under investigation. EPR is shown to be highly sensitive method allowing one to follow the changes of molecular structure during the production of green coke. The results obtained in the work with the help of EPR are in good agreement with the results of NMR spectroscopic studies. It is concluded that evaluation of the molecular structure of intermediate coking products is necessary to improve the composition of initial raw material and technological operations.
NI-, CO- AND NI-CO-CONTAINING CATALYSTS BASED ON BIOCHAR FOR STEAM REFORMING OF ISOBUTANOL
Authors: KULIKOVA M.V. , OSIPOV A.K. , PONOMAREV S.A. , LOKTEV A.S. , DEDOV A.G.
Published: October 2024

Ni-, Co- and Ni-Co-containing catalysts for steam reforming of isobutanol were obtained by biochar impregnation with water-alcohol solutions of metal salts. Biochar was synthesised by the hydrothermal carbonisation of cellulose with subsequent thermal treatment of the obtained materials under the conditions of limited oxygen access. The catalysts were characterised using a complex of physicochemical methods (IR spectroscopy, BET, temperature programmable desorption of ammonia, scanning electron microscopy in combination with local electron microprobe analysis, X-ray diffraction and X-ray fluorescence analysis). It is found that the sample 2.5%Ni-2.5%Co/C (where the number before the metal symbol means its mass content calculated for the mass of reduced catalyst, %) provides a high yield of hydrogen (58%) from isobutanol reforming.
INVESTIGATION OF THE COMBUSTION OF BIOCHAR OBTAINED BY HYDROTHERMAL CARBONISATION AND TORREFACTION OF SAWDUST
Authors: PUDOVA YA.D. , KRYSANOVA K.O.
Published: October 2024

The effect of the temperature regimes of hardwood sawdust thermochemical treatment (hydrothermal carbonization and torrefaction) on biochar properties and combustion characteristics are investigated. The mass yields of biochars were considered from the viewpoint of the processes that take place during thermochemical treatment, along with the changes in the elemental composition resulting from these processes. The optimal method and temperature regime of thermochemical treatment were determined. The effect of the method and temperature of sawdust thermochemical treatment on the composition of gaseous products from biochar combustion was assessed by FTIR spectroscopy combined with thermogravimetric analysis. Two main stages of biochar combustion were detected: the phase of removal and combustion of volatile substances (up to 400 °C) and the phase of semi-coke combustion (above 400 °C). The analysis carried out by means of FTIR spectroscopy during combustion allowed us to determine the released components of the gaseous mixture and to observe thermochemical decomposition of biochar components in the real time mode. Investigation of biochar combustion showed that an increase in sawdust processing temperature reduces the formation of gaseous products at the first stage of combustion and promotes an increase in the amount of carbon dioxide at the second stage.
PHYSICOCHEMICAL AND BIOSPECIFIC PROPERTIES OF A POROUS CARBON SORBENT MODIFIED WITH SULPHOSALICYLIC ACID
Authors: SEDANOVA A.V. , P'YANOVA L.G. , DELYAGINA M.S. , KORNIENKO N.V. , LEONT'EVA N.N.
Published: October 2024

A mesoporous carbon sorbent modified with sulphosalicylic acid by adsorption from aqueous solutions has been synthesized. The optimal modification parameters were selected: the ratio, concentration, the duration of impregnation and heat treatment stages, and pH. The physicochemical properties of the samples have been studied: textural characteristics, qualitative and quantitative composition of surface functional groups, the amount of applied modifier, adsorption and desorption properties. The adsorption characteristics of the studied samples with respect to organic dyes methylene blue and methanyl yellow are determined. It has been established that during desorption for 48 h, ~ 68% and ~ 82% of the initial concentration of sulphosalicylic acid applied to the sample pass into the aqueous solution, modelling the intestinal medium and into ethanol, respectively. In this case, a decrease in the pH of the initial solutions by 6 units is observed. High antibacterial properties of the modified carbon sorbent towards Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae have been established in vitro.
COALS OF KUZBASS AS THE MAIN RAW MATERIAL TO RECOVER THE PRODUCTION OF ACTIVE COAL
Authors: MUKHIN V.M.
Published: October 2024

The breadth of the use of activated carbons (AC) in many areas of economy, ecology and defense of the country is shown. The unique physicochemical characteristics of AC are denoted, and their modern determination is presented. It is established that the Russian Federation is currently lagging far behind industrialised countries in the output of AC production. Attention is paid to the coals of Kuzbass as a raw material for the large-tonnage production of AC. Various technologies for manufacturing active coals on this basis are considered.