bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhibition of TFF3 Synergizes with c-MET Inhibitors to Decrease the CSC-like Phenotype and Metastatic Burden in ER+HER2+ Mammary Carcinoma
Authors: Lobie Peter , He Chuyu , Wang Xuejuan , Chiou Yi-Shiou , Basappa Basappa , Zhu tao , Pandey Vijay
Published: October 2024

The interaction between HER2 and ERα signaling pathways contributes to resistance to anti-estrogen and HER2-targeted therapies, presenting substantial treatment challenges in ER-positive (ER+) HER2-positive (HER2+) mammary carcinoma (MC). Trefoil Factor-3 (TFF3) has been reported to mediate resistance to both anti-estrogen and anti-HER2 targeted therapies in ER+ and ER+HER2+ MC, respectively. Herein, the function and mechanism of TFF3 in ER+HER2+ MC was delineated; and novel combinatorial therapeutic strategies were identified. Elevated expression of TFF3 promoted the oncogenicity of ER+HER2+ MC cells, including enhanced cell proliferation, survival, anchorage-independent growth, 3D growth, cancer stem cell-like (CSC-like) phenotype, invasion, migration, and xenograft growth. Targeting TFF3 with an interfering RNA plasmid or a small-molecule inhibitor (AMPC) inhibited these oncogenic characteristics, highlighting the therapeutic potential of targeting TFF3 in ER+HER2+ MC. Furthermore, a high-throughput combinatorial anti-cancer compound library screening revealed that AMPC preferentially synergized with receptor tyrosine kinase c-MET inhibitors (c-METis) to reduce cell survival and the CSC-like phenotype. The combination of AMPC and c-METis also synergistically suppressed in vivo growth of ER+HER2+ MC cell-derived xenografts and abrogated lung metastasis. Mechanistically, TFF3 was observed to activate c-MET signaling through a positive-feedback loop to enhance the CSC-like phenotype of ER+HER2+ MC. Therefore, proof of concept is provided herein that antagonizing of TFF3 is a promising therapeutic strategy in combination with c-MET inhibition for the treatment of ER+HER2+ MC.
Identification of the factors influencing the liquid sloshing wave height in a sloped bottom tank under horizontal excitation using PCA approach
Authors: Ren Wenhao , Zhong Zuowei
Published: October 2024

The dynamic behavior of liquid storage tanks represents a pivotal research area concerning structural safety and reliability. Notably, sloped bottom tanks exhibit heightened sloshing with reduced liquid mass compared to rectangular counterparts. This study adopts a hybrid approach that seamlessly integrates the linear potential-flow theory, renowned for its analytical rigor in fluid dynamics modeling, with principal component analysis (PCA), a potent technique for dimensionality reduction and feature extraction. The hybrid methodology initially employs the linear potential-flow theory to simulate the fundamental fluid dynamics within sloped bottom tanks subjected to horizontal excitation. Subsequently, PCA is applied to the simulated data, identifying key components of liquid sloshing wave height variations. Through the analysis of these principal components, an accurate model of the maximum sloshing wave height is derived, achieving a close correlation with ANSYS simulation results, exhibiting a correlation coefficient of 0.98 and a mean absolute error of 2.5%. This approach uniquely facilitates the evaluation of the intricate interplay between multiple factors, including tank geometry and excitation frequency, on the dynamic characteristics of liquid sloshing waves in sloped bottom tanks. The findings emphasize the significant influence of tank height and tilt angle, with a sensitivity analysis indicating a 4.07% increase in maximum wave height per degree increase in tilt angle under specified experimental conditions. This comprehensive methodology not only enhances understanding of the complex liquid sloshing phenomenon but also provides precise theoretical and practical guidance for fluid sway control strategies. Future investigations will further expand the scope and elucidate the fundamental mechanisms governing liquid sloshing dynamics.
Optimizing Concrete Sustainability: Impact of Bagasse Ash and Stone Dust on Mechanical Properties and Durability
Authors: Khan Muhammad Adeel , Zhang Boshan , Ahmad Mahmood , Niekurzak Mariusz , Khan Muhammad Salman , Sabri Mohanad Muayad Sabri , Chen Weizhen
Published: October 2024

Effectively managing and reducing industrial and municipal waste is crucial for addressing environmental issues like pollution and resource depletion. Since cement production is a major contributor to greenhouse gases, using eco-friendly building materials becomes essential in the fight against global warming and for a more sustainable future. This research proposes an innovative approach to concrete technology by concurrently exploring the use of SCBA and SD as partial replacements for cement and sand at varying ratios in eco-strength concrete mixes for 28 and 34 MPa. This combination of materials will help to evaluate the economic and environmental benefits of using these alternative materials, such as reduced reliance on traditional cement and sand resources, potential cost savings, and the mitigation of environmental impacts through waste utilization. The influence of BA and SD on workability, mechanical properties, and durability were experimentally investigated. The introduction of 9% SCBA as a substitute for cement and 40-50% SD as a replacement for sand leads to a substantial enhancement in both compressive and tensile strength. This improvement is attributed to factors such as pozzolanic reactions, enhanced particle packing, and optimal curing conditions. Additionally, a notable increase in flexural strength is observed with 6% cement replacement using SCBA and 40% sand replacement with SD. However, it is observed that as the ratios of SCBA and SD increase, there is a concurrent rise in water absorption. The findings reveal that the optimized mix, derived from response surface analysis, closely aligns with the control mix in terms of mechanical strengths, emphasizing its appropriateness for structural applications.
Genome-wide identification of the potato GGPS gene family and analysis of its response to abiotic stress
Authors: Man Quancai , LI Wei , Chen Xiaotian , Gao Shunjuan , Jia Mingfei , Zhang Shuqing , Cui Jianghui
Published: October 2024

Background: Geranylgeranyl pyrophosphate synthase (GGPS) plays a crucial role in terpene biosynthesis, contributing to the synthesis of carotenoids, chlorophylls, and various phytohormones. This study aims to identify and characterize the GGPS gene family in potato (Solanum tuberosum) to understand its role in carotenoid synthesis and response to abiotic stress.
Results: Eleven GGPS genes (StGGPSs) were identified across the potato genome, distributed unevenly on seven chromosomes. These genes were categorized into three subfamilies based on protein structure and phylogenetic analysis. Covariance analyses revealed one pair of replicated genes within the potato genome and several homologous pairs between potato and other species such as Arabidopsis and tomato. RNA-seq data and qPCR data indicated differential expression of StGGPS genes in potato patches of different colors, highlighting their role in response to abiotic stresses.
Conclusion: The study provides new insights into the evolution of the StGGPS gene family in potato, emphasizing its significance in regulating carotenoid synthesis and abiotic stress response. These findings lay the groundwork for future research on the genetic manipulation of GGPS genes to enhance stress tolerance in potatoes.
The Spatiotemporal Structure of Information Diffusion: A Study Based on the Growth Curve Model and Social Network Analysis
Authors: Zhu Panlong , Zhou Yunqian , Xia Yixue
Published: October 2024

Due to the rapid development of internet technology, it has provided convenient online channels for information diffusion, which has resulted in the formation of complex network structures during the process of information diffusion. In response to the previous studies that solely focused on the temporal or spatial aspects of information diffusion network structures, overlooking the combined characteristics of both discrete time points and continuous process accumulation within the diffusion process, we propose a novel approach from a dual-temporal and spatial perspective. This approach utilizes the growth curve model and social network analysis to analyze network structures of information diffusion. Firstly, leveraging the life cycle theory and employing the logistic model, we partition the process of information diffusion into three distinct phases - the latency period, the diffusion period, and the fading period - based on two characteristic time points, t1 and t2. This approach allows us to develop a dynamic evolutionary model for the social network structure of information diffusion. Secondly, incorporating temporal evolution into the spatial perspective, we conduct spatial structure analysis based on time-evolving data from three phases: (0,t1), (t1,t2), and (t2,tk). This comprehensive approach allows for the presentation of the network spatial structure characteristics of information diffusion throughout its temporal evolution. Lastly, taking the “Tangshan Assault Incident” as an example, we employ social network analysis theory to conduct empirical research from the perspectives of network spatial structure analysis with temporal evolution and network spatial structure analysis at a specific time point. Through this approach, we derive the characteristics of the information diffusion network structure under different perspectives. The results indicate that the research methodology of information diffusion based on the growth curve model and social network analysis, coupled with a temporal evolution perspective to examine network spatial structural characteristics, reveals the uneven distribution of information diffusion. Furthermore, under the accumulative effect of time, it enables better identification of key nodes and groups with enduring influence and potential for explosive impact.
New low-cost and compact experimental system for characterization of porous materials by quasi-equilibrated thermodesorption of nonane or water
Authors: Makowski Wacław , Yaremenko Nikita , Gryta Patrycja , Cieślik-Górna Monika , Korzeniowska Aleksandra , Majda Dorota
Published: October 2024

The new low-cost, simple and compact experimental system for characterization of porous materials by quasi-equilibrated temperature-programmed desorption and adsorption (QE-TPDA) based on the miniature microprocessor-controlled thermal conductivity sensor Sensirion STC31 has been described in detail. The performance of the new system has been tested in QE-TPDA measurements of nonane for high silica zeolites Y and ZSM-5, as well as for a series of ordered mesoporous silicas SBA-15. Although very good qualitative agreement of the QE-TPDA profiles measured in the new system with those observed in a standard one was found, slightly lower saturation sorption capacities based on the new profiles were obtained. The pores size distributions (PSDs) calculated from the new nonane QE-TPDA profiles for SBA-15 silicas showed very good agreement with those obtained from N2 adsorption isotherms using the NLDFT method. An excellent correlation between the pore size values based on both sets of PSDs was found. The new system was also applied in the QE-TPDA of water for selected metal-organic frameworks (MOFs). The QE-TPDA profiles of water observed for two fumarate containing MOFs Al-fum (aka Basolite A520) and MIL-88A were consistent with the adsorption-desorption isotherms obtained in a standard manometric apparatus. Hydrothermal stability tests of these MOFs, based on prolonged water QE-TPDA measurements, revealed the onset of structure degradation of Al-fum at 350°C and at 250°C for MIL-88A.
Single-step synthesis of high surface area activated carbon from polyethylene terephthalate plastic waste for environmental treatment applications
Authors: Lai Hoan Thi , Le Quoc Anh , Tran Nga Thuy , Tran Chinh , Ho Phuong Hien , Nguyen D. Duc , Thi Hoai Phuong Nguyen , La Duong Duc
Published: October 2024

The escalating environmental concerns regarding plastic waste necessitate innovative strategies for waste management and resource utilization. This study presented a novel approach for synthesizing high surface area activated carbon through a single-step process, using polyethylene terephthalate (PET) plastic waste as the precursor and potassium hydroxide (KOH) as the activating agent. The optimal activation conditions were established using a weight ratio of 1:1 of PET to KOH and annealing for 15 minutes at 700 oC. The conversion efficiency of PET plastic trash into activated carbon exceeded 20%. The materials underwent thorough characterization using scanning electron microscopy (SEM), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) analysis, and Fourier transform infrared spectroscopy (FTIR). The activated carbon obtained has a mesoporous structure and a surface area of 1831.166 m2/g. The activated carbon-prepared plastic waste showed high removal efficiency for the organic dyes in an aqueous solution, with a maximum adsorption capacity of 131.58 mg/g. The successful transformation of plastic waste into a valuable resource underscores the importance of innovative approaches to mitigating environmental degradation. The synthesized activated carbon's efficacy in adsorption-based remediation strategies establishes its potential for addressing various pollution issues and opens new avenues for valuing plastic waste.
Assessment of Potentially Toxic and Rare Earth Elements in Surface Soils of Dong Nai, Vietnam
Authors: Vo Tran Quang-Thai , Tran Quang-Thien , Tran Tuan-Anh , Tuong Thi Thu-Huong , Nguyen Thi Huong-Lan , Chau Thi Nhu-Quynh , Le Nhu-Sieu , Vo Thi Mong-Tham , Le Xuan-Thang , Truong Duc-Toan , Phan Quang-Trung , Nguyen Huu-Nghia , Nguyen Minh-Dao
Published: October 2024

This study investigates the quantities of Rare Earth Elements (REEs) and Potentially Toxic Elements (PTEs) in Dong Nai Province's surface soils. Atomic Absorption Spectrometry (AAS) and Instrumental Neutron Activation Analysis (INAA) are used to determine element concentrations. To validate the concentration results, established reference materials (NIST 2711 and IAEA Soil-7) were used. Element concentrations followed a certain order, with Mn, Cr, V, and Zn dominating, except for Al, which was used to determine the enrichment factor. Arsenic (As) concentrations ranged from 0.8 to 37.5 mg/kg, exceeding global averages but below Vietnam quality standards. Cadmium (Cd) concentrations ranged from 0.03 to 0.16 mg/kg, below global averages and quality standards. Cobalt (Co) and chromium (Cr) concentrations ranged from 0.5 to 135.1 mg/kg and 18 to 844 mg/kg, respectively, with notable percentages of samples exceeding global averages. Copper (Cu) and lead (Pb) exhibited elevated concentrations, with varying proportions exceeding quality standards. Manganese (Mn) and antimony (Sb) exceeded global averages in a significant percentage of samples. Vanadium (V) concentrations surpassed the crustal average in over half of the sites. Zinc (Zn) concentrations were below reference values. REEs showed significantly higher concentrations than global soil averages, with a substantial proportion of samples exceeding reference values. Geo Accumulation Index (Igeo), Enrichment Factor (EF), and Pollution Load Index (PLI) analyses provided a detailed numerical assessment of contamination and soil quality. Statistical analysis showed correlations and clusters of toxic elements and highlighted the spatial distribution of samples based on elemental compositions.
PAR2 deletion in the osteoblast lineage affords long-term cartilage protection in experimental osteoarthritis
Authors: Huesa Carmen , McGrath Sarah , Dunning Lynette , Vieri Maria , McCulloch Kendal , McIntosh Kathryn , Brown Tatiana , Cole John , Plevin Robin , Rowan Drew , Hof Rob van ‘t , Ferrell William , Lockhart John , Goodyear Carl
Published: October 2024

Protease-activated receptor 2 (PAR2) plays a pivotal role in the early stages of surgery-induced murine osteoarthritis OA. It remains to be determined however, whether PAR2 contributes to later stages of disease pathology and which cellular compartments drive pathological changes. Thus, we characterised OA pathology in global, chondrocyte- or osteoblast-specific PAR2 knockout mice up to 12 months after OA induction. While wild-type mice display a gradual increase in cartilage damage/loss, PAR2 knockout mice had significantly reduced cartilage pathology. Notably, removing PAR2 specifically in osteoblasts, but not in chondrocytes, substantially improved cartilage health. Interrogation of the osteoblast compartment revealed that PAR2 has a divergent role during osteoblast development and maturation compared to its function in already differentiated cells. This suggests that PAR2 expression in the bone compartment promotes joint deterioration in later stages of OA, highlighting the important role of bone in OA and the therapeutic potential of targeting PAR2.
Discovery of Unconventional and Non-intuitive Self-assembling Peptide Materials using Experiment Driven Machine Learning
Authors: Batra Rohit , Talluri Y Nissi , Sankaranarayanan Subramanian , Fry H. Christopher
Published: October 2024

The synthesis of secondary structures such as β-sheet assembly in peptides poses significant challenges, as their formation is governed by complexity of molecular interactions, sequence-specific behavior, and influence of various environmental factors such as solvent, pH, and temperature. While rational design strategies have been attempted to predict peptide sequences that form desired nanostructures, these methods are often biased and ineffective, particularly when dealing with the complexities associated with β-sheet formation. Computational models also struggle to reliably predict β-peptide formation due to the limited understanding of the vast chemical space and the lack of comprehensive experimental data. Furthermore, existing models often fail to capture the diversity and non-intuitive nature of sequences capable of forming β-sheets, leading to a constrained discovery process. To address these issues, we developed an integrated high-throughput experimental workflow and an active learning-based AI framework to better predict the β-sheet formation propensity of peptide sequences. By focusing on sequences where ML predictions deviate from conventional design strategies, we synthesized and tested 268 pentapeptides, discovering 96 that successfully formed β-sheet assemblies. The ML models were found to surpass the commonly used β-sheet propensity table in identifying β-sheet forming sequences, especially for cases that do not contain valine, a high propensity β-sheet conformer. Furthermore, several diverse, non-intuitive and unusual β-sheet forming pentapeptides (for e.g., ILFSM, LMISI, MITIY, MISIW, and WKIYI) were identified by the ML models. Novel chemical trends were mined by analyzing the ML models and a user-friendly web-interface is provided to make these models accessible to the community. Overall, this work underscores the need for AI driven experimental exploration of diverse peptide chemistries and provides a robust strategy to overcome the biases and limitations inherent in current rational design methods to form secondary structures like β-sheets.
Rejuvenation driven reprograming in T lymphocytes
Authors: Lanna Alessio , D'Ambra Clara , Delpero Manuel , Capitani Melania , Chocarro Luisa , Rinaldi Federica , Karin Michael
Published: October 2024

Rejuvenation restores cellular function lost with age, but it is not known to confer properties the cell lacked in its younger past. We found that Disruptors of sestrin-MAPK interactions (DOS) reprogramed senescent T cells into new stem like T clones with different T cell receptors (TCRs). DOS targeted sestrin-MAPK complexes (sMAC) to ubiquitin-dependent proteasomal degradation, resulting in long-term sestrin transcriptional inhibition, increased T cell fitness, and generation of long-lived stem like memory clones. Strikingly, DOS reactivated juvenile related Rag re-expression, leading to antigen-specific TCR rearrangements in formerly senescent cells. As such, rejuvenated T cells, with stem features and new TCRs, combated multiple lethal challenges never previously encountered in their lifetime, with no need for vaccination. T cell rejuvenation confers new properties whilst preserving cellular state, which unravels an unknown rejuvenating principle in biological systems.
О некоторых источниках и проблемах перевода кантовского термина «Ding an sich»
Authors: Круглов А.Н
Published: October 2024

В статье указывается на латинские и немецкие философские тексты как на терминологические источники для образования кантовского понятия «Ding an sich», а именно на «Немецкую метафизику» Хр. Вольфа, «Метафизику» А.Г. Баумгартена, «Архитектонику» И.Г. Ламберта и «Философские опыты о человеческой природе и ее развитии» И.Н. Тетенса. Отрицается терминологическое влияние понятия Дж. Локка «thing in itself» из «Опыта о человеческом разумении» на И. Канта. На основе сопоставительного изучения фрагментов «Критики чистого разума» и других печатных произведений Канта, черновых заметок и записей его лекций, а также всех русских переводов «Критики чистого разума» и «Пролегоменов» уточняется перевод ряда важных выражений первой «Критики» Канта, а также обсуждается проблема синонимии кантовских выражений «Ding an sich selbst» и «Sache an sich selbst».

The paper deals with German and Latin philosophical texts, namely Chr. Wolff’s “German Metaphysics”, A.G. Baimgarten’s “Metaphysics”, J.H. Lam- bert’s “Architectonics” and J.N. Tetens’s “Philosophical essays on human nature and its development”, that have contributed to the problem of terminological sources of Kant’s “Ding an sich”. I deny the terminological influence of Lock’s “thing in itself” from his “An Essay Concerning Human Understanding” on I. Kant. Based on comparative analysis of some fragments that have been taken from “Critique of Pure Reason”, other published papers, reflections and lectures recordings, as well as all Russian translations of “Critique of Pure Reason” and “Prolegomena to Any Future Metaphysics”, I specify the translation of important terms from the first Kant’s “Critique” and, in addition, discuss the problem of synonymy of two Kant’s terms “Ding an sich selbst” and “Sache an sich selbst”.
MEMPOPULERKAN PROSEDUR HAK CUTI HAID DAN IMPLIKASI HUKUMNYA BAGI PEKERJA PEREMPUAN DI INDONESIA
Authors: Nail Muhammad Hoiru
Published: October 2024

Female workers get privileges in the form of menstruation leave rights which are not owned by male workers. This privilege is certainly not a form of discrimination in the world of work but is a strong consideration of the biological nature of female workers. The problem that will be studied is how the flow/steps for applying for menstruation leave for female workers and what are the legal implications if the company does not exercise the right to leave for menstruation. The methodology used is normative legal research. Female workers are required to have a doctor's certificate as a condition for applying for menstruation leave at the company, there are criminal sanctions and fines that can be threatened with companies that do not give permission for menstruation leave for female workers.
POLITIK UANG PEMILIHAN KEPALA DESA DALAM PERSPEKTIF MASYARAKAT TULUNGAGUNG
Authors: . Muksin , . Ladin
Published: October 2024

This research aims to find out and analyze community perceptions regarding the existence of money politics in village head elections and forms of money politics in village head elections. The research method used is an empirical research method consisting of primary data and secondary data. The research results of the two problems that the author examined are (1) Some people perceive that money politics or giving other goods in village head elections has become a habit that has occurred in Indonesia. (2) That there are various forms of money politics in society during village head elections, not only giving money, but also providing goods such as basic necessities and even giving school equipment which also occurs in the village head election process.
POLIGAMI DALAM PEMIKIRAN KH HUSEIN MUHAMMAD PERSPEKTIF SOSIOLOGI HUKUM
Authors: Solikhudin Muhammad , Faidati Ashima
Published: October 2024

Polygamy has been interestingly discussed and giving rise to pros and cons with its all related arguments until now. This paper aims to analyze polygamy based on the thinking of KH Husein Muhammad and is strengthened by the theory of legal sociology. This research is qualitative, particularly the type of library research, and uses a conceptual approach. According to KH Husein Muhammad's thought, polygamy is not a practice born out of Islamic tradition. Islam did not initiate polygamy. Long before Islam came, the polygamy tradition had become a form of patriarchal civilization practice. According to KH Husein Muhammad, there must be an effort to reconstruct the Marriage Law related to polygamy. The phenomenon that is often encountered is a bad situation due to polygamy which can gradually harm the future of the nation's generation. This situation is immediately resolved by all parties, both the public and the state, through the improvement of laws or regulations. Referring to the process of gradual improvement as exemplified by the al-Qur'an for many cases, including cases of slavery, it is time for the process towards monogamous marriage to be carried out. Although the Qur'an mentions the issue of polygamy in Surah an-Nisa'(4): 3, however, there is a Hadis of the Prophet Muhammad that opposed Ali bin Abi Talib's plan to polygamy on Fatimah ra. KH Husein Muhammad criticized several manhajs of polygamy by arguing that monogamy rejects more harm than polygamy does. Therefore, monogamy must take precedence to be implemented because polygamy which causes arbitrary actions and endangers his wife and children must be avoided, in accordance with a sociological view of law, namely looking at law or norms from a social aspect.
PENERAPAN AKAD SALAM DAN ISTISHNA’ DALAM PERNIAGAAN KONTEMPORER DITINJAU DARI AYAT DAN HADIS AHKAM
Authors: Mufitasari Dwi Nur , Ni'mah Zulfatun , Adistalaili Maya Asri
Published: October 2024

This paper aims to analyze the application of the salam and istishna’ contracts in contemporary business in terms of the ahkam verses and hadith. This research uses a literature method with a normative juridical approach, examining theories, concepts and regulations related to the salam and istishna’ contracts. The Data were collected from documents from sharia financial institutions and literature on greetings and istishna’, the Al-Qur'an, hadith and were analyzed using content analysis. The findings of the research show that the implementation of the salam and istishna’ contracts in sharia financial institutions as a contemporary business subject is in accordance with the provisions of the Qur'an Al-Baqarah verse 282. Moreovet, it has been carried out with a written agreement, recorded by an authorized official, namely a notary and carried out in the presence of two witnesses, in accordance with QS. An-Nisa verse 29. Another reason is that it does not contain elements of falsehood and is in accordance with the Hadith of the History of Ibnu Majah Number2185 and it applies the principle of like and like.
PERBEDAAN PENENTUAN WAKTU IMSAK BULAN RAMADAN: Telaah Ijtihad Ilmiah Berdasarkan Ketinggian Fajar Shadiq
Authors: Maratus Nuril Farida
Published: October 2024

The determination of imsak time during the month of Ramadan is crucial for Muslims in Indonesia, as it serves as a guideline for fasting. Imsak is a precautionary measure to ensure that sahur (pre-dawn meal) does not extend beyond its time and usually begins a few minutes before the Fajr (dawn) prayer. Differences in imsak schedules have been a point of contention, leading to confusion among the public. This research aims to analyze the variations in the determination of imsak time during Ramadan in Indonesia, with a focus on the standards for the height of the shadiq dawn. The article is composed, using library research methods by gathering relevant literature data. The research findings indicate that one of the main factors causing differences in imsak timing is the variance in the standards for the height of the shadiq dawn. This arises from differences in ijtihad (independent reasoning) regarding the sun's position at dawn between -20° and -18°. These different interpretations of the beginning of dawn affect imsak schedules, resulting in an approximately 8 minutes variation in imsak times across Indonesia.
Transcriptome Profile and Gene Expression During Different Ovarian Maturation Stages of Macrobrachium rosenbergii (De Man, 1879)
Authors: Mohd Pauzi Mardhiyyah  , Muhammad Faiz Zakaria  , Adnan Amin-Safwan  , Mamat Nur- Syahirah  , Yeong Yik Sung  , Hongyu Ma  , Mhd Ikhwanuddin
Published: October 2024

Macrobrachium rosenbergii, or giant river prawn, is the most economically crucial cultured freshwater crustacean. A predominant challenge in developing crustacean aquaculture is reproduction management, particularly ovary maturation, where identifying regulative mechanisms at the molecular level is critical. Ovary is the primary tissue for studying gene and protein expressions involved in crustacean growth and reproduction. Despite significant interest in M. rosenbergii, its gene discovery has been at a relatively small scale compared to other genera. In this study, comprehensive transcriptomic sequencing data for different maturation stages of the ovary of M. rosenbergii were observed. The 20 female M. rosenbergii samples evaluated were categorised into four maturation stages, 1 to 4. A total of 817,793,14, 841,670,70, 914,248,78 and 878,085,88 raw reads were obtained from stages 1, 2, 3 and 4, respectively. The assembled unique sequences (unigenes) post-clustering (n = 98013) was 131,093,546 bp with an average size of 1,338 bp. The BLASTX unigene search against National Centre for Biotechnology Information (NCBI), non-redundant (NR), nucleotide sequence (NT), Kyoto Encyclopaedia of Genes andGenomes Orthology (KO), Swiss-Prot, Protein Family (PFAM), Gene Ontology (GO), and euKaryotic Orthologous Groups (KOG) databases yielded 27,680 (28.24%), 7,449 (7.59%), 13,026 (13.29%), 22,606 (23.06%), 29,907 (30.51%), 30,025 (30.63%) and 14,368 (14.65%) significant matches, respectively, totalling to 37,338 annotated unigenes (38.09%). The differentially expressed genes (DEG) analysis conducted in this study led to identifying cyclin B, insulin receptor (IR), oestrogen sulfotransferase (ESULT) and vitellogenin (Vg), which are critical in ovarian maturation. Nevertheless, some M. rosenbergii ovarian maturation-related genes, such as small ubiquitin-like modifier (SUMO)-activating enzyme subunit 1, E3 ubiquitin-protein ligase RNF25, and neuroparsin, were first identified in this study. The data obtained in the present study could considerably contribute to understanding the gene expression and genome structure in M. rosenbergii ovaries throughout its developmental stage.
On exactly solvable Yang-Baxter models and enhanced symmetries
Authors: Idiab Khalil , van Tongeren Stijn Jurrien
Published: October 2024

We study Yang-Baxter deformations of the flat space string that result in exactly solvable models, finding the Nappi-Witten model and its higher dimensional generalizations. We then consider the spectra of these models obtained by canonical quantization in light-cone gauge, and match them with an integrability-based Bethe Ansatz approach. By considering a generalized light-cone gauge we can describe the model by a nontrivially Drinfel’d twisted S matrix, explicitly verifying the twisted structure expected for such deformations. Next, the reformulation of the Nappi-Witten model as a Yang-Baxter deformation shows that Yang-Baxter models can have more symmetries than suggested by the rr matrix defining the deformation. We discuss these enhanced symmetries in more detail for some trivial and nontrivial examples. Finally, we observe that there are nonunimodular but Weyl-invariant Yang-Baxter models of a type not previously considered.
The relationship between bank lending and economic factors in the regions of Kazakhstan
Authors: Bekbossinova Assel , Vasa Laszlo , Nurekenova Elvira
Published: October 2024

Understanding the impact of economic factors on bank lending is crucial in Kazakhstan’s modern economy, characterized by volatile inflation and fluctuations in real wages. This paper aims to investigate the link between bank lending and economic factors such as inflation, real wages, and consumer expenditure in a regional context. Data from the Bureau of National Statistics and the National Bank, covering the period from 2012 to 2022, were used to uncover how economic factors influence bank lending. For the analysis, various economic indicators were integrated through normalization and averaging. Analysis reveals significant regional disparities in real wages and consumer expenditures, which impact the demand for bank credit. The results of the correlation matrix showed that both real wages (P-value < 0.001) and inflation (P-value < 0.001) significantly impact bank lending, with an R² value of 0.998, indicating that the model explains 99.8% of the variation in bank lending. The regression analysis highlights that regions with higher real wages, such as Astana, Almaty, and Atyrau, provide the most favorable conditions for banking sector growth, demonstrated by a strong relationship between wages and bank lending. In contrast, regions with lower wage levels, such as Turkestan and Zhambyl, show a significantly weaker connection (around 0.65), reflecting their lower attractiveness for banking investment and emphasizing the need for policies to address social inequality. The Durbin-Watson test confirmed no autocorrelation in residuals (DW = 1.89), although heteroscedasticity was detected, suggesting the need for further model adjustments. The study emphasizes the importance of developing economic policies that can balance regional development and improve financial stability.
AcknowledgmentsThis research has been funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (Grant “Development of mechanisms for reducing social inequality and improving the welfare of the population of Kazakhstan” AP19174744).
Impact of organizational culture on healthcare supply chain resilience in Jordan: Moderating role of technology integration
Authors: Al-Ma’aitah Noor
Published: October 2024

This study aims to investigate the impact of organizational culture (i.e., rational, hierarchical, and group) on healthcare supply chain resilience (SCR) in Jordan. This paper further examines the moderating role of technology integration on the relationship between organizational culture and healthcare SCR. Cross-sectional research was conducted, and participants were recruited from different hospitals in Jordan. An electronic survey was employed to collect the responses from 304 participants, including senior professionals designated as doctors, nurses, ray technicians, physical therapists, procurement officers, pharmacists, and lab technicians with more than three years of work experience. There was no statistically significant influence of rational culture on healthcare SCR (p-value = 0.156) and an adverse impact of hierarchical culture on healthcare SCR (p-value = 0.030). Group culture had a statistically significant impact on healthcare SCR (p-value = 0.007). Technology integration had an influential moderating influence on the association between rational culture and healthcare SCR (p-value = 0.042) and the association between hierarchical culture and healthcare SCR (p-value = 0.0129). However, technology integration had no moderating influence on the association between group culture and healthcare SCR (p-value = 0.331). The analysis revealed that group culture has an influential impact on healthcare SCR, while hierarchical culture has a negative impact on healthcare SCR. Moreover, technological integration was observed to improve the beneficial influence of rational culture and the negative effects of hierarchical culture on healthcare SCR. However, the technology integration was not observed to moderate the relationship between group culture and healthcare SCR.
Acknowledgment The author acknowledges all the associated personnel who, in any reference, contributed to the completion of this study.
Optimal trajectory control for the yaw system vibration and crawling jitter of a wind turbine
Authors: Liu Tingrui , Cui Qinghu , Xu Dan
Published: October 2024

A kinematics model of the yaw system is investigated based on an equilibrium position in yaw motion, aiming at the suppression of the yaw system vibration and crawling jitter (CJ) of a wind turbine. A nonlinear CJ model is constructed and integrated to form the governing equation of the system. An optimal trajectory control (OTC) strategy is investigated to suppress the nonlinear system vibration. This strategy uses a differential evolution algorithm to perform an optimal planning along a given ideal path, thereby achieving a goal of suppressing vibrational amplitude and frequency. A tracking of the optimal trajectory is achieved based on proportional-derivative (PD) control using the differential evolution, to ensure minimal energy consumption throughout the entire tracking process. Currently, there is little literature discussing the CJ phenomenon in detail. The CJ phenomenon is an extreme situation that occurs during yaw motion and has significant destructive power under extreme working conditions. The control planning proposed in this article can completely eliminate the CJ phenomenon and suppress the yaw vibration. The engineering application effect of the proposed control algorithms is demonstrated based on a type of concise OPC technique.
Increased Diagnostic Yield of Early and Mild Carpal Tunnel Syndrome by Using Median-to-Ulnar Comparative Study
Authors: Fatima Syeda Eesha , Bano Safia , Khadim Meryam , Numan Ahsan
Published: October 2024

Background: Carpal Tunnel Syndrome (CTS) is the most common focal entrapment neuropathy caused by median nerve compression in the carpal tunnel. Clinically there is pain and paresthesia in the distribution of median nerve. Electrodiagnostic (EDX) studies are gold standard means of confirming the diagnosis. Early and mild CTS cause discomfort for patients but remains undiagnosed during routine motor and sensory nerve conduction studies.
Objective: To evaluate the most sensitive electro diagnostic method i.e. comparative Median-to-Ulnar motor and sensory study, for diagnosis of early and mild CTS.
Methods: Comparative analytical cross sectional study was done in Department of Neurology, Mayo hospital Lahore, from June to November 2022. We included 50 clinically symptomatic CTS patients of both genders of age between 20 and 55 years in our study and comparison was done with healthy control. Patients were symptomatic with normal conventional EMG/NCS. Patients having moderate to severe or incidental CTS and patients with underlying polyneuropathy and radiculopathy were excluded. For comparative analysis student’s t test (two tailed) was used. EDX findings were noted in the predesigned proforma along with history & demographic variables.
Results: Out of 50 patients, females were 35 and males were 15, so female: male was 7:3. Mean age of the patient group was 37.24 ± 2.27 years. Sensitivity was highest for the median-versus-ulnar palmar mixed study (80.0%), followed by median-versus-ulnar digit 4 sensory latency (32.0%) and median distal sensory latency (14.0%). Median distal motor latency had the lowest sensitivity (10.0%).
Conclusion: Conventional nerve conduction study methods i.e. median distal motor latency and median distal sensory latency tests are less sensitive in diagnosing early and mild CTS. Highly sensitive electrophysiological tests including median-versus-ulnar palmar mixed study and median-versus-ulnar digit 4 sensory study should be incorporated in the evaluation of patients with early and mild CTS to increase the diagnostic yield of CTS.
Effect of ozone on Vibrio removal in a simulated earthen shrimp pond
Authors: Sitthi Sitthakarn , Mirutanaphai Mongkol , Satanwat Penpicha , Powtongsook Sorawit , Pungrasmi Wiboonluk
Published: October 2024

This study investigated the efficacy of ozone treatment on Vibrio pathogen removal within a simulated earthen shrimp pond, conducted in three phases. First, physical and chemical properties of the soil, alongside the Vibrio pathogen, were assessed. Results indicated neutral pH levels, high organic matter, and organic carbon content, with a Vibrio pathogen load of 1.0 ± 0.0 × 103 CFU/mg. Second, ozone treatment was applied, comparing its effectiveness in Vibrio pathogen control between treated and untreated soil sets. The treated set exhibited a significantly lower Vibrio pathogen load (6.00 ± 1.41 × 103 CFU/mg) compared to the untreated control (2.00 ± 2.12 × 105 CFU/mg), resulting in a 97.23% eradication efficiency. Concurrently, ammonia rates decreased with ozone, indicating potential benefits for shrimp aquaculture. Finally, ozone application in a simulated earthen pond over 45 days effectively controlled Vibrio pathogens. In the untreated soil set, Vibrio pathogen levels rose to 9.48 ± 1.73 × 105 CFU/mg, while in the ozone-treated, they ranged from 6.5 ± 2.12 × 103 to 1.25 ± 0.29 × 105 CFU/mg. Shrimp growth parameters, including average daily gain, survival rates, and feed conversion ratio, were compared between groups, suggesting ozone treatment's feasibility without adverse effects on shrimp growth. Water quality parameters remained within suitable ranges for shrimp cultivation. These findings highlight ozone's potential as an effective method for Vibrio pathogen control in shrimp aquaculture, with implications for industry sustainability and productivity.
Toplumdilbilimin Dil Öğretimiyle İlişkisi Üzerine
Authors: Kahraman Mehmet
Published: October 2024

Toplumsal yaşamda, dil ve toplum bireylerin hayatında belirleyici role sahiptir. Dil öğretimi, Toplumdilbilim ile birçok yönden ilişkilidir. Toplumdilbilim’in temel iddiası, ‘‘dilin çeşitli olduğu ve sürekli değiştiği’’ tezine dayanmaktadır. Dil öğretiminde, öğretilen kayıt (resmi dil) ile öğrenilen kayıt (kullanılan dil) arasında oluşan farklar, öğreticinin toplumdilbilimsel farkındalığı nispetinde öğretilebilir.
Toplumdilbilim ile dil öğretimi arasında ne gibi ilişkiler kurularak, ne gibi katkılar sunabileceğini, dili iletişimsel yeterlik, toplumsal ve kültürel bağlamları ile sınıf, yaş, cinsiyet, etnik köken gibi sosyal etkenlerle ilişkilendirmek suretiyle ele alıp incelenmeye çalışılmıştır.
Bu çalışma, Toplumdilbilim konuları ile dil öğretimi arasındaki ilişkinin nasıl kurulabileceğini incelemeyi amaçlamaktadır. Bu araştırmada nitel araştırma yöntemi kullanılmış, tarama, derleme ve gözlem yöntemlerinden yararlanılmıştır. Dil öğretiminde anadil veya ikinci/yabancı dil edinimi veya öğretiminde rol oynayan durum, bağlam, ortam ve sosyal etkenler ile dil seçimlerini etkileyen temel faktörleri tanımak ve çağdaş dil öğretim ortamlarında nasıl kullanılabileceğini değerlendirmeye çalışmıştır.
Dinâmicas de imperialismo e colonialismo na era digital
Authors: Polonini Janaína Fernandes Guimarães
Published: October 2024

The investigation presents a reflection on data market strategies anchored in imperialism and colonialism in the digital era. It discusses the commodification of internet user data on different digital platforms, as well as strategies to mitigate these practices and studies on the topic. The research is descriptive, bibliographic and qualitative, reflecting on data, information, power and manipulation of society through digital platforms. The bibliographic survey was carried out on the Capes Periodicals Portal considering only articles published in open access and peer-reviewed, covering the entire period available until December 2023. The data market carried out by large technology corporations exerts dominance over the economy and culture, through the control and exploitation of user information. This phenomenon raises concerns related to privacy, concentration of power and digital exclusion. The data market presents significant challenges in the digital era, demanding effective responses from civil society, governments and international organizations. To address this problem, it is essential that Brazil strengthens its technology industry and implements data protection policies.
Dark Triad Traits and Workplace Performance on the Iowa Gambling Task (IGT)
Authors: Volkova Nataliia , Kurpatov Andrey
Published: October 2024

Background

Psychologists have recently turned their focus to the “dark side” of workplace behavior, particularly negative traits that impact professional environments.

Methods

In this exploratory study, we examined the Dark Triad traits Machiavellianism, narcissism, and psychopathy among 3,112 bank employees. Additionally, we analyzed the Iowa Gambling Task (IGT) performance in a subset of 1,613 participants to explore correlations between Dark Triad traits and decision-making. We also investigated differences based on sex and job position.

Results

Our findings reveal that men scored higher on Dark Triad traits than women, reinforcing well-established findings. Furthermore, sales managers and premium client managers displayed the highest levels of Machiavellian strategies, though overall, bank employees showed significantly lower Machiavellianism scores compared to published Russian norms. While IGT performance showed no sex differences, it varied between managers and non-managers. A significant negative correlation emerged between Machiavellianism and psychopathy and good deck choices on the IGT, with a linear regression indicating that lower Dark Triad scores predicted better decision-making.

Conclusion

Further research is needed to explore the relationship between affective decision-making and dark personality traits.
FEN EĞİTİMİNDE DİJİTAL HİKÂYE KULLANIMINA İLİŞKİN ÇALIŞMALARIN İÇERİK ANALİZİ: TÜRKİYE ÖRNEĞİ
Authors: Çakı Merve Nur , Çam Aylin
Published: October 2024

Teknoloji, her alan gibi eğitim alanını da etkilemektedir. Çalışmanın amacı, fen eğitiminde dijital hikâye kullanımı gerçekleştirilen çalışmaları doküman incelemesi yöntemiyle incelemektir. Yapılan araştırmada, ülkemizde 2014-2021 yılları arasında fen eğitimi kapsamında dijital hikâyelerin kullanımına ilişkin çalışmalar YÖK Tez, Google Scholar ve ERIC üzerinden elde edilen tezler ve makaleler doküman analizi yöntemiyle incelenmiştir. İçerik analizi doğrultusunda da ilgili kodlar, temalar ve açıklamalar oluşturulmuştur. Çalışmada ayrıca Sözbilir, Kutu ve Yaşar (2012) tarafından geliştirilen “Makale Sınıflama Formu” kullanılmış olup elde edilen tezler ve makaleler form aracılığı ile tasnif edilmiştir. Çalışmada incelenen tezlerde ve makalelerde en çok kullanılan veri toplama aracı görüşme olarak belirlenmiştir. İncelenen tezlerde örneklemi, ortaokul öğrencileri oluştururken makalelerde öğretmen adayları oluşturmaktadır. İncelenen tezlerde en çok kullanılan araştırma yöntemi karma yöntem, makalelerde ise nitel araştırma yöntemidir. Çalışmanın sonunda fen eğitiminde dijital hikâye kullanımının oldukça az olduğu istatistiksel olarak da gözlenmiştir. Bu çalışma ile beraber fen eğitiminde dijital hikâye kullanımının arttırılması, fen eğitimi ile dijital hikâye arasındaki bağın kuvvetlendirilmesi ve dijital hikâyeler ile fen eğitiminde birçok çalışmanın yapılabilmesi açısından alana katkı sağlayacağı düşünülmektedir.