bluuebunny/crossref_metadata_2025 huggingface dataset:
Managing cash flow. Practicum
Authors: Жуков Павел , Zhukov Pavel
Published: August 2019

Textbook "managing cash flow" is based on a similar discipline which is part of the educational programme of the Financial University for training Bachelors to direction of preparation 38.03.02 "management", financial profile. Discipline treats all topics of general courses in financial management and corporate finance. Difference of discipline is that it focuses on cash flow management (rather than capital, profitability, etc.) and consequently, the discipline examines corporate finance and financial management in terms of cash flow management.
Cash flow management is usually the essence of the work of a Finance Manager, and it treats activities of an Organization in terms of cash flows. That is usually a feature of outlook of financial manager and distinguishes it from other managers. Due to the nature of their work, financial managers must also bear in mind the issues of competitiveness, efficiency, profitability and sustainability of the company, which commonly are the focus of the General Manager. The workshop aims to develop the skills necessary for this activity.
The Euclidean k-Supplier Problem
Authors: Nagarajan Viswanath , Schieber Baruch , Shachnai Hadas
Published: August 2019

The [Formula: see text]-supplier problem is a fundamental location problem that involves opening [Formula: see text] facilities to minimize the maximum distance of any client to an open facility. We consider the [Formula: see text]-supplier problem in Euclidean metrics (of arbitrary dimension) and present an algorithm with approximation ratio [Formula: see text]. This improves upon the previously known 3-approximation algorithm, which also holds for general metrics. Our result is almost best possible as the Euclidean [Formula: see text]-supplier problem is NP-hard to approximate better than a factor of [Formula: see text]. We also present a nearly linear time algorithm for the Euclidean [Formula: see text]-supplier in constant dimensions that achieves an approximation ratio better than three.
Anaesthesia in thoracic trauma
Authors: Ryan Aoife , Borland Karla , Bradbrook Carl
Published: August 2019

Peri-anaesthetic management of thoracic trauma in dogs and cats can be challenging, due to the likelihood of both respiratory compromise and pain associated with sustained injuries. Many medications and techniques used in anaesthesia depress the respiratory system, which can cause further complications. The aims of this article are to discuss anaesthetic and analgesic management of these cases, with reference to available evidence in both veterinary and human literature. Pathophysiology, appropriate drug choices and techniques are outlined. A case example of a dog with thoracic wall trauma following a dog bite is included.
Randomised study of the effects of neuromuscular electrical stimulation and low-level laser therapy on muscle activation and pain in patients with knee osteoarthritis
Authors: Melo Mônica de Oliveira , Pompeo Klauber Dalcero , Baroni Bruno Manfredini , Sonda Francesca Chaida , Vaz Marco Aurélio
Published: August 2019

Background

The combined effects of low-level laser therapy and neuromuscular electrical stimulation on knee osteoarthritis have yet to be analysed. This study aimed to determine the individual and combined effects of laser therapy and electrical stimulation on muscle activation and pain in older people with knee osteoarthritis.

Methods

A total of 45 women aged 60–75 years with knee osteoarthritis were randomised into three groups to receive stimulation, laser or stimulation plus laser therapy. All three groups underwent a 4-week control period (without intervention) followed by an 8-week intervention period. The effects of the interventions on muscle inhibition, electrical activity and pain were analysed.

Findings

There was a decrease in muscle inhibition (effect size ≥0.6) and a reduction in pain (effect size >1.2) in all three groups. All therapies generated an increase in electrical activity (effect size 0.1–0.5).

Conclusions

Laser alone or in combination with electrical stimulation promoted similar increases in muscle activation and pain relief.
Molecular Simulations have Boosted Knowledge of CRISPR/Cas9: A Review
Authors: Ray Angana , Felice Rosa Di
Published: August 2019

Genome editing allows scientists to change an organism’s DNA. One promis-ing genome editing protocol, already validated in living organisms, is basedon clustered regularly interspaced short palindromic repeats (CRISPR)/Casprotein-nucleic acid complexes. When the CRISPR/Cas approach was firstdemonstrated in 2012, its advantages with respect to previously availabletechniques, such as zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), immediately got attention and the methodhas seen a surge of experimental and computational investigations since then.However, the molecular mechanisms involved in target DNA recognition andcleavage are still not completely resolved and need further attention. The largesize and complex nature of CRISPR/Cas9 complexes has been a challengefor computational studies, but some seed results exist and are illuminatingon the cleavage activity. In this short review, we present recent progressin studying CRISPR/Cas9 systems by molecular dynamics simulations withcoarse-grained and atomistic descriptions, including enhanced sampling.
The Assessment of Self-Determination in Spanish and American Adolescents: The Self-Determination Inventory: Student Report
Authors: Shogren Karrie A. , Shaw Leslie A. , Mumbardó-Adam Cristina
Published: August 2019

The purpose of this study was to explore the cross-cultural validity of the Self-Determination Inventory: Student Report, a newly developed measure of self-determination grounded in Causal Agency Theory. The tool was translated to Spanish and administered to American and Spanish adolescents. The sample was structured to include adolescents with and without intellectual disability in both cultural contexts. More than 3,000 students in the U.S. and Spain aged 13 to 22 completed the assessment. Findings suggest that the same set of items can be used across cultural contexts and in youth with and without intellectual disability, although there are some specific differences in item functioning across students with and without intellectual disability in Spain that must be further researched. There were specific patterns of differences in latent self-determination means, with students with intellectual disability scoring lower in the U.S. and Spain. Implications for assessment research and practice in diverse cultural contexts are explored.
Interactions of High School Students With Intellectual and Developmental Disabilities in Inclusive Classrooms
Authors: Chung Yun-Ching , Douglas Karen H. , Walker Virginia L. , Wells Rachel L.
Published: August 2019

As inclusive opportunities increase for students with disabilities, additional research is needed to examine high school students' classroom interactions. This descriptive study explores the nature of the social interactions of 10 high school students with intellectual and developmental disabilities (IDD) in the general education classroom. Findings from our observations indicated that students with IDD interacted with peers during approximately one out of every four minutes and interacted with the general educator during one out of every 10 minutes, less than their peer comparisons' interactions with peers and teachers. Students with IDD were present (M = 89.9%) and in proximity to peers (M = 71.7%) during the majority of the class period. We discuss additional results along with practical implications, limitations, and future research directions.
Circular RNAs in Urine of Kidney Transplant Patients with Acute T Cell-Mediated Allograft Rejection
Authors: Kölling Malte , Haddad George , Wegmann Urs , Kistler Andreas , Bosakova Andrea , Seeger Harald , Hübel Kerstin , Haller Hermann , Mueller Thomas , Wüthrich Rudolf P , Lorenzen Johan M
Published: August 2019

BACKGROUND

Circular RNAs (circRNAs) have recently been described as novel noncoding regulators of gene expression. They are detectable in the blood of patients with acute kidney injury. We tested whether circRNAs were present in urine and could serve as new predictors of outcome in renal transplant patients with acute rejection.

METHODS

A global circRNA expression analysis using RNA from urine of patients with acute T cell-mediated renal allograft rejection and control transplant patients was performed. Dysregulated circRNAs were confirmed in a cohort of 62 patients with acute rejection, 10 patients after successful antirejection therapy, 18 control transplant patients without rejection, and 13 stable transplant patients with urinary tract infection.

RESULTS

A global screen revealed several circRNAs to be altered in urine of patients with acute rejection. Concentrations of 2 circRNAs including hsa_circ_0001334 and hsa_circ_0071475 were significantly increased. These were validated in the whole cohort of patients. hsa_circ_0001334 was upregulated in patients with acute rejection compared with controls. Concentrations of hsa_circ_0001334 normalized in patients with acute rejection following successful antirejection therapy. hsa_circ_0001334 was associated with higher decline in glomerular filtration rate 1 year after transplantation.

CONCLUSIONS

CircRNA concentrations are significantly dysregulated in patients with acute rejection at subclinical time points. Urinary hsa_circ_0001334 is a novel biomarker of acute kidney rejection, identifying patients with acute rejection and predicting loss of kidney function.
Estudo do conhecimento tradicional de pescadores do litoral Sul do Espírito Santo sobre a carcinofauna acompanhante da pesca de camarões
Authors: Braga Adriane Araújo , Zappes Camilah Antunes , Oliveira Ana Carolina Machado de
Published: August 2019

O presente estudo visa identificar as espécies de crustáceos mais comuns pesca de arrasto segundo o conhecimento de pescadores de três municípios do litoral sul do Estado do Espírito Santo, sudeste do Brasil, e apresentar alguns aspectos relacionados à sua biologia. Entre setembro de 2016 e fevereiro de 2017 foram realizadas observações do cotidiano dos pescadores artesanais e entrevistados 92 pescadores. Todos os entrevistados são do sexo masculino, com idade que varia de 18 a 71 anos, baixa escolaridade e atuam na pesca entre 1 e 41 anos. Em Anchieta, as espécies alvo são os camarões sete-barbas, rosa e branco, enquanto que em Piúma e Marataízes apenas o sete-barbas é alvo da pesca. Nestas comunidades, a carcinofauna acompanhante é composta por siris e caranguejos.  Segundo os pescadores, esses crustáceos apresentam semelhanças nos estágios juvenil e adulto, com tais fases ocorrendo no mesmo local. Foi descrita por eles os caracteres de dimorfismo sexual desses organismos. As informações obtidas junto às comunidades tradicionais podem contribuir para a conservação das espécies alvo e da fauna acompanhante, uma vez que o conhecimento etnobiológico é equivalente com a literatura. Este saber local pode ser utilizado em propostas de manejo sustentável bem como na diminuição do impacto sobre as populações das espécies alvo e fauna acompanhante.
Dysbiosis of the Duodenal Mucosal Microbiota Is Associated With Increased Small Intestinal Permeability in Chronic Liver Disease
Authors: Raj Ashok S. , Shanahan Erin R. , Tran Cuong D. , Bhat Purnima , Fletcher Linda M. , Vesey David A. , Morrison Mark , Holtmann Gerald , Macdonald Graeme A.
Published: August 2019

OBJECTIVES:

Chronic liver disease (CLD) is associated with both alterations of the stool microbiota and increased small intestinal permeability. However, little is known about the role of the small intestinal mucosa-associated microbiota (MAM) in CLD. The aim of this study was to evaluate the relationship between the duodenal MAM and both small intestinal permeability and liver disease severity in CLD.

METHODS:

Subjects with CLD and a disease-free control group undergoing routine endoscopy underwent duodenal biopsy to assess duodenal MAM by 16S rRNA gene sequencing. Small intestinal permeability was assessed by a dual sugar (lactulose: rhamnose) assay. Other assessments included transient elastography, endotoxemia, serum markers of hepatic inflammation, dietary intake, and anthropometric measurements.

RESULTS:

Forty-six subjects (35 with CLD and 11 controls) were assessed. In subjects with CLD, the composition (P = 0.02) and diversity (P < 0.01) of the duodenal MAM differed to controls. Constrained multivariate analysis and linear discriminate effect size showed this was due to Streptococcus-affiliated lineages. Small intestinal permeability was significantly higher in CLD subjects compared to controls. In CLD, there were inverse correlations between microbial diversity and both increased small intestinal permeability (r = −0.41, P = 0.02) and serum alanine aminotransferase (r = −0.35, P = 0.04). Hepatic stiffness was not associated with the MAM.

DISCUSSION:

In CLD, there is dysbiosis of the duodenal MAM and an inverse correlation between microbial diversity and small intestinal permeability.

TRANSLATIONAL IMPACT:

Strategies to ameliorate duodenal MAM dysbiosis may ameliorate intestinal barrier dysfunction and liver injury in CLD.
KAJIAN KRITIS ATAS KITAB AL-TAFSIR AL-TAWHIDI KARYA HASAN AL-TURABI
Authors: Abha Muhammad Makmun
Published: August 2019

هذه الرسالة تبحث عن كتاب التفسير التوحيدي لمؤلفه الدكتور حسن الترابي. يثير الكاتب إلى بحث هذا الكتاب لما فيه من المنهج الموضوعي البنائي الذي سماه مؤلفه بالمنهج التوحيدي في محاولته لإعادة إظهار هدى القرآن على شكل موحد لسياقات القرآن ككلية لا جزئية. ومن هذا البحث اكتشف الكاتب نتيجتين أساسيتين: أما (النتيجة الأولى) فهي أن الطرق التي سلك بها حسن الترابي في كتابة هذا الكتاب هي (1) أن يذكر اسم السورة التي سيفسرها مع الإتيان ببيان اسمها، و(2) أن يبين نوع السورة مكية أم مدنية، و(3) أن يوضح ما تحتوي عليه السورة من تعليق الآيات بجميعها على وجه الأكمل بحيث يتحد غرض الآيات الواردة في السورة، و(4) أن يبين تفاصيل المعاني من الآيات مع تفصيل قضية موضوعاتها إن كان الوضوع في السورة أكثر من موضوع واحد، و(5) أن يبين مجملات المعاني في كل قضية الموضوعات مع بيان ما يوحّد ويعلّق ما في قضية واحدة وقضية آخر. وأما (النتيجة الثانية) فهي أن ما جاء به الدكتور حسن الترابي من المنهج التوحيدي ليس فيه شيئ من التجديد لأنه لا يزال داخلا في استخدام تيار النظريات السابقة وهي نظرية المناسبة بل ولا يعطي منهجا جديدا في بناء المنهج البنائي الذي ذكره المؤلف بالمنهج التوحيدي إضافة إلى أن ما جاء به الدكتور حسن الترابي من المنهج التوحيدي كان مماثلا لما جاء به محمد محمود الحجازي من منهج الوحدة الموضوعية في القرآن الكريم في أن كلا من هذين المنهجين يعين أن هناك سورا يقتضيها موضوع أساسي واحد وتندرج تحته موضوعات كثيرة مكملة للموضوع الأساسي وأن هناك سورا يقتضيها كثير من الموضوعات ثم تتعلق قضية كل من الموضوعات بقضية أخرى على شكل يوحدها.
KESETARAAN DAN KELAS SOSIAL DALAM PERSPEKTIF AL-QUR'AN
Authors: Barir Muhammad
Published: August 2019

This study is an effort to find general moral-social in the Qur’an, which focused on the issue of social inequality in social class (patronage, economic class, and race). This research will inspect interweaving between text and context because of comprehensive interpretation not only accepted from text but also must accepted from the context, which appear surrounding the text. From this reason, the double movement will used to analyze every verse of the Qur’an which talking about social class issue with socio-historical approach. More extent, there are three questions will be answered in this research: 1. How did the problem of social class after Qur’anic era? 2. How did the problem of social class in the revelation era? And 3. How does the Qur’anic concept about social class?
PENGAJIAN KITAB BULU>G AL-MARA>M DALAM MAJLISUZZIKR BRUNEI DARUSSALAM: KAJIAN HADIS
Authors: Mukaromah Kholila
Published: August 2019

ewline"> This article studies hadiths used in Majlisuzzikr led by Habib Abdul Hamid al-Mahdaly in Brunei Darussalam context. The object of this research islimited by investigating the recording video of the lectures on Bulūg alMarām, composed by Ibn ajar al-‘Asqalānī, that can be downloaded fromcyberspace, you tube. However, the study of hadith there has a close relationwith the government that put into effect the Islamic law (syariat). Theexistence of hadith study in this Majlis apparently is inclined to supportthe government of Sultan Hassanal Bolkiah. According to the Alfatihmapping of explanation (pensyarh} an), this hadith study can be classifidto the category of classical explanation with bayani reasoning. For examplerelation to hadith explaination about the Prophet’s daily activities to givepriority from right to left that said by Al-Mahdaly that is everyone thatcontradict with it will be accused as neglectful person and because of it canbe entered to the hell in the hereafter
MELACAK ARGUMENTASI PENGGUNAAN SEMIOTIKA DALAM MEMAHAMI HADIS NABI
Authors: Afwadzi Benny
Published: August 2019

ne"> During this time, the study of semiotics of hadith looks has less ofinteresting in the study of discourse text. Most scholars who engagedin this study prefer to bring semiotics to read the signs mentioned inverses of the Koran. In fact, the hadith of the Prophet himself as secondafter Koran contains the actual signs also interesting to uncover by thesemiotics. Through this paper, the author founds there are at least threearguments of using of semiotics in the understanding of the hadith,the fist, ‘semiotics’ turned out to have been used by classical scholars inunderstanding the hadith; second, the hadith is the language and thelanguage is a sign; and third, as a development of the hadith study inthe present era
Konstruksi Pemahaman Masyarakat Terhadap Hadis "Kullu Bid'atin Dlalalah"
Authors: Mu'awwanah Nafisatul
Published: August 2019

This article discusses the problems of bid’ah in society. The problems originated from differences in the public’s understanding of the hadis kullu bid’atin dlalalah. Such defferences include the definition of bid’ah, bid’ah classification, and the methods used to judge the practices that are not practiced by Rasulullah, companions, and scholars of the Salaf. The situation often cause conflicts in society. To solve this problem, Peter L. Berger gave some solution by theory of social contruction. This theory told us that the problems of bid’ah are caused by three processes, there are eksternalitation, objectivation, and internalitation. And the problems can be solved by two processes, there are institusionalitation and socialization.Key Word: Bid’ah, Hadis, Sosial Contruction.
Memahami Para Orientalis Dalam Mengkaii al-Quran dan Hadis: Perbedaan Memahami dan Mengimani Menurut Alasdair Macintyre
Authors: Zuhri Saifuddin
Published: August 2019

Kajian yang dilakukan oleh Barat memang unik. Seperti yang dilakukanoleh para orientalis pengkaji al-Quran dan Hadis, semisal Goldziher,Watt Smith, dan lainnya. Mereka melakukan riset dan memahami alQuran dan hadis tanpa adanya (meng)iman(i) di hatinya. Bahkan skeptikyang dihasilkan. Melalui kajian yang dilakukan oleh Alasdair MacIntyre,pembaca dapat memahami, mengapa para orientalis ini tidak mamputertembus hidayah meskipun telah membolak-balik pesan al-Qurandan Hadis. Kajian MacIntyre ini dimulai dari bahasan para antropologdalam mengkaji ritual, kepercayaan, dan agama-agama, dengan mencobamengeksplorasi makna understand, believe, intelligible, dan skepticism.
Wanita Mengimami Shalat laki-laki (Studi atas Hadis yang Melarang dan Hadis yang Membolehkan)
Authors: Imron Ali
Published: August 2019

Tulisan ini melakukan kajian sanad dan matan atas dua kelompok hadis yang saling bertentangan (ta’arudh), yakni hadis yang melarang wanita menjadi imam bagi laki-laki dalam shalat dan hadis yang membolehkan. Dari penelitian ini tampak bahwa kedua hadis ini sama-sama dipandang sebagai hadis yang shahih, alias keduanya tidak memiliki problem dan masalah, terutama dari aspek rijal yang meriwayatkannya. Namun demikian, dalam praktik di masyarakat, perlu dipertimbangkan aspekaspek lain, seperti kaidah-kaidah fiih demi mendapatkan mashlahat yang lebih besar bagi masyarakat dunia, khususnya umat Islam.
REGULATION OF RADIO FREQUENCY SPECTRUM AND ITS IMPLEMENTATION CHALLENGES IN THE PERPECTIVE OF INTERNATIONAL LAW
Authors: Pramono Agus , Mahoro Jean Claude Geofrey
Published: August 2019

The radio frequency spectrum is a limited natural resource which is very vital and strategic in the operation of telecomunications. Considering that the radio frequency spectrum is a limited natural resources, its management is regulated internatioanlly by the International Telecomunication Union (ITU), in which details are set out in the radio regulations (RR) as an integal part of the ITU Convention. The study is based on applicable legal regulations and is supported by literature studies. The result of the study indicate that the regulation of the radio frequency spectrum is based on radio regulation, international agreements within the ITU throught the World Radiocommunication Conference forum. The implications of regulating the use off the radio frequency spectrum always take into account the general public needs for the dynamics of the progress in telecomunications technology, of which implementation of its utilization rest on the principle of fairness and equity between regions and efficiency. Therefore, all policies made are directed at creating a market balance, ensuring fair competition between telecomunication operators as a potential to prevent market dominance, as well as protecting consumers.
Modeling of Clinical Phenotypes Assessed at Discrete Study Visits
Authors: Huang Emily , Varadhan Ravi , Carlson Michelle
Published: August 2019

In studies of clinical phenotypes, such as dementia, disability, and frailty, participants are typically assessed at in-person clinic visits. Thus, the precise time of onset for the phenotype is unknown. The discreteness of the clinic visits yields grouped event time data. We investigate how to perform a risk factor analysis in the case of grouped data. Since visits can be months to years apart, numbers of ties can be large, causing the exact tie-handling method of the Cox model to be computationally infeasible. We propose two, new, computationally efficient approximations to the exact method: Laplace approximation and an analytic approximation. Through extensive simulation studies, we compare these new methods to the Prentice-Gloeckler model and the Cox model using Efron’s and Breslow’s tie-handling methods. In addition, we compare the methods in an application to a large cohort study (N = 3,605) on the development of clinical frailty in older adults. In our simulations, the Laplace approximation has low bias in all settings, and the analytic approximation has low bias in settings where the regression coefficient is not large in magnitude. Their corresponding confidence intervals also have approximately the nominal coverage probability. In the data application, the results from the approximations are nearly identical to that of the Prentice-Gloeckler model.
Effect of PWHT Conditions on Toughness and Creep Rupture Strength in Modified 9Cr-1Mo Steel Welds
Authors: Nishikawa Satoru , Hasegawa Tadayuki , Takahashi Makoto
Published: August 2019

We clarified the effect of post weld heat treatment (PWHT) conditions on the toughness and creep rupture strength of modified 9Cr–1Mo steel weldments used for high temperature components of ultra-supercritical power plants. Fracture appearance transition temperature (FATT) decreased as PWHT temperature increased, and for all of the weld metals of tungsten inert gas welding, submerged arc welding and shielded metal arc welding, FATTs were lower than 293 K when the PWHT temperature was higher than 1,008 K. In contrast, in the uniaxial creep test with a loaded stress of 108 MPa, the creep rupture strength of the specimen on which PWHT was carried out for a holding time of 7.2 ks was significantly decreased when the PWHT temperature was more than 1,033 K. Therefore, the appropriate PWHT temperature range to maintain the toughness and creep fracture strength was 1,008 K ≤ T ≤ 1,033 K.
Satire: An explication
Authors: Park-Ozee Dakota
Published: August 2019

Over the past two millennia, satire has transformed from a uniquely Greco-Roman theatrical and poetic form into an ambiguous catch-all applied to political and sociocultural commentary, humor, parody, sarcasm and irony. Despite being a subject of study in any number of fields, explications of satire are limited. It is likely for this reason that there are inter- and intra- disciplinary disconnects in theoretical and methodological approach. Given the contemporary proliferation of satirical work, a proper explication of satire will improve text identification, empirical measures, and interdisciplinary collaboration in satirical research. To that end, this paper explicates satire, evaluates contemporary satirical research in the context of this explication, and recommends future research lines to expand the study of a pervasive construct.
Moral judgment of disparagement humor
Authors: Koszałkowska Karolina , Wróbel Monika
Published: August 2019

The aim of the present study was to analyze the link between the five moral codes proposed in the Moral Foundations Theory and moral judgment of disparagement humor. We presented racist, sexist, homophobic, religion-disparaging and neutral jokes to a group of 108 participants, asking them whether they found laughing at a particular joke moral or immoral. Additionally, participants rated the level of amusement and disgust evoked by each joke. We also measured participants’ moral foundations profiles (Care, Fairness, Loyalty, Authority, and Sanctity). The results confirmed that Care and Fairness were significantly linked to moral judgment of racist, sexist and homophobic jokes, whereas Loyalty, Authority and Sanctity were associated with moral judgment of religion-disparaging jokes. Moreover, these relationships were mediated by emotional responses of amusement and disgust (except for racist jokes, for which we observed no mediating role of amusement).
“Hercules the grocer?”: low-key humor in The Twelve Tasks of Asterix
Authors: Williams Hamish
Published: August 2019

The theme of resistance has been a popular topic inAsterixscholarship, whether this resistance is applied to the historical Gauls in their defiance of imperial Rome, to later nationalist or regionalist sentiments in France against invading forces, to any small groups of locals in opposition to foreign or global forces, to a cultural war between France/Europe and America, or to the dominant educational canon of Western history and literature. What is missing in current scholarship onAsterixis a discussion ofhowthese acts of resistance are created and implemented. To that end, this paper identifies ‘low-key’ humor as a seminal means of achieving this resistance inAsterix; this effect involves a ‘lowering’ where figures of the grand or sublime are supplanted, nullified, or defeated by the more restrained figures of the commonplace. The aim of this paper is to identify the typical character of this low-key humor inAsterixthrough analyzing an exemplary version of this humor – in the animated filmThe Twelve Tasks of Asterix(1976). From the perspective of humor studies, this analysis serves as a corrective to a commonly held impression of theAsterix bandes dessinéesas being characterized by more overt or puerile forms of humor. From the perspective ofAsterixscholarship, this study is the first to analyze one of the animated films; far from being an outlier in the oeuvre,The Twelve Tasksboth consolidates and extends the lowering humor ofAsterixby opening up the possibilities of a new medium.
Crystal structure of dimethyl 3,12-dibenzyl-6,10-diphenyl-3,12-diazapentacyclo [6.3.1.02.7.04.11.05.9]-dodecane-7,11-dicarboxylate — acetone (2/1), C40H38N2O2 ⋅ 0.5C3H6O
Authors: Wang Ya-Nan , Wu Yan , Tian Ye
Published: August 2019

C83H82N4O5, monoclinic, P21/c (no. 14), a = 21.705(8) Å, b = 18.455(6) Å, c = 17.774(7) Å, β = 112.216(6)°, V = 6591(4) Å3, Z = 4, R
gt(F) = 0.0647, wR
ref(F
2) = 0.1531, T = 128 K.
The crystal structure of 1,5-dinitro-2,3,4-trichlorobenzene, C6H1Cl3N2O4
Authors: Peilan Wang , Jianlong Wang , Lizhen Chen , Zihao Zhao , Cai Cao
Published: August 2019

C6H1Cl3N2O4, monoclinic, P21/c (no. 14), a = 5.3193(2) Å, b = 11.3307(4) Å, c = 15.1131(5) Å, β = 93.329(1)°, V = 909.35(6) Å3, Z = 4, R
gt(F) = 0.0264, wR
ref(F
2) = 0.1098, T = 100 K.
The cocrystal structure of 4-nitropyrazole — acetic acid (1/1), C5H7N3O4
Authors: Yunzhang Liu , Lizhen Chen , Jianlong Wang , Luyao Zhang , Jian Ruan
Published: August 2019

C5H7N3O4, monoclinic, P1̄ (no. 2), a = 5.1166(12) Å, b = 8.711(2) Å, c = 8.744(2) Å, α = 103.169(7)°, β = 90.454(6)°, γ = 96.121(7)°, V = 377.08(16) Å3, Z = 2, R
gt(F) = 0.0619, wR
ref(F
2) = 0.1241, T = 173(2) K.
Frailty and Function in Heart Failure: Predictors of 30-Day Hospital Readmission?
Authors: Keeney Tamra , Jette Diane U. , Cabral Howard , Jette Alan M.
Published: August 2019

Background and Purpose:

Although there have been decreases noted in 30-day readmission rates for persons with heart failure since enactment of the Hospital Readmissions Reduction Program, costs related to heart failure readmissions remain high. Consequently, there is a need to better identify persons with heart failure who are at risk for 30-day hospital readmission. Therefore, this study aimed to compare the ability of measures of function and frailty to predict 30-day hospital readmissions for adults 65 years and older with heart failure.

Methods:

Secondary data analysis using the 2011 National Health and Aging Trends Study analysis merged with Medicare claims data. Logistic regression modeling was used to compare the ability of function (Short Physical Performance Battery) and frailty (Fried's Physical Frailty Phenotype) to predict 30-day readmission. Receiver operating characteristic curves were constructed to examine the ability of function and frailty to identify those who were readmitted.

Results and Discussion:

Frailty and function demonstrated comparable ability to predict 30-day readmissions (R
2 = 0.087 and R
2 = 0.087, respectively). Neither measure identified persons at risk for readmission (AUCSPPB = 0.608; AUCPFP = 0.587).

Conclusions:

Functional assessment demonstrated comparable ability to predict 30-day readmissions in persons with heart failure compared with frailty. However, neither measure was able to identify persons at high risk for readmission. Although frailty status is emphasized in research for older adults with heart failure, functional status is an important patient-level factor associated with readmission.
Analysis of a Submaximal Cycle Test to Monitor Adaptations to Training: Implications for Optimizing Training Prescription
Authors: Capostagno Benoit , Lambert Michael I. , Lamberts Robert P.
Published: August 2019

Capostagno, B, Lambert, MI, and Lamberts, RP. Analysis of a submaximal cycle test to monitor adaptations to training: Implications for optimizing training prescription. J Strength Cond Res 35(4): 924–930, 2021—The Lamberts and Lambert Submaximal Cycle Test (LSCT) was developed to monitor training adaptation to optimize the training prescription of cyclists. However, it is not known which of the variables within the LSCT are most closely associated with changes in training status. The aim of this study was to retrospectively analyze the LSCT data of cyclists (n = 15) who completed a 2-week high-intensity interval training intervention. The cyclists were retrospectively allocated to 1 of 2 groups based on the change in their 40-km time trial (40-km TT) performance. The “adapters” (n = 7) improved their 40-km TT performance, while the “nonadapters” (n = 8) failed to improve their 40-km TT performance. The variables measured in the LSCT were analyzed to determine which measures tracked the improvements in 40-km TT performance the best. Heart rate recovery increased significantly during the training period in the “adapters” group, but decreased in the “nonadapters” group. Mean power output in stage 2 of the LSCT tended to increase during the high-intensity interval training period in the “adapters” group and was unchanged in the “nonadapters” group. The findings of this study suggest that heart rate recovery and mean power output during stage 2 are the most sensitive markers to track changes in training status within the LSCT.
Transcranial Direct Current Stimulation Does Not Improve Countermovement Jump Performance in Young Healthy Men
Authors: Romero-Arenas Salvador , Calderón-Nadal Giancarlo , Alix-Fages Carlos , Jerez-Martínez Agustín , Colomer-Poveda David , Márquez Gonzalo
Published: August 2019

Romero-Arenas, S, Calderón-Nadal, G, Alix-Fages, C, Jerez-Martínez, A, Colomer-Poveda, D, and Márquez, G. Transcranial direct current stimulation does not improve countermovement jump performance in young healthy men. J Strength Cond Res 35(10): 2918–2921, 2021—The main purpose of this study was to report the effects of transcranial direct current stimulation (tDCS) on countermovement jump (CMJ) performance in young healthy men. Seventeen healthy male subjects volunteered for the study (age: 22.4 ± 2.6 years; body mass: 71.8 ± 8.7 kg; height: 174.6 ± 5.9 cm; and CMJ height: 36.8 ± 6.3 cm). After a familiarization session, subjects underwent 3 experimental conditions, 7 days apart, in a randomized, double-blinded crossover design: anodal, cathodal, and sham tDCS. The stimulation was applied over the dorsolateral prefrontal cortex for 15 minutes. During experimental sessions, subjects completed a warm-up and 3 CMJ trials separated by 1 minute before and after each of the 3 experimental conditions. Countermovement jump height and muscular peak power were extracted from the best CMJ in each moment. A 2-way repeated-measures analysis of variance with time and condition as factors were performed for CMJ height and muscular peak power. Effect size analysis was conducted using Cohen's d coefficient. The analysis did not show either significant main effects or interactions for both time and condition factors in the CMJ performance (p > 0.05). Furthermore, effect size was trivial for all conditions (d: 0.01–0.14) in CMJ height and muscular peak power. These findings suggest that tDCS may not be a valuable tool to improve vertical jump performance.
Effects of Maturation on Physical Fitness Adaptations to Plyometric Jump Training in Youth Females
Authors: Romero Claudio , Ramirez-Campillo Rodrigo , Alvarez Cristian , Moran Jason , Slimani Maamer , Gonzalez Javier , Banzer Winfried E.
Published: August 2019

Romero, C, Ramirez-Campillo, R, Alvarez, C, Moran, J, Slimani, M, Gonzalez, J, and Banzer, WE. Effects of maturation on physical fitness adaptations to plyometric jump training in youth females. J Strength Cond Res 35(10): 2870–2877, 2021—The aim of this study was to compare the effects of maturation on physical fitness adaptations to plyometric jump training (PJT) in youth females. Jumping, sprinting, change of direction speed, endurance, and maximal strength were measured pre-post 6 weeks of PJT in 7th- and 10th-grade subjects. In the seventh grade, subjects formed a PJT group (Plyo-7, n = 10; age, 12.7 ± 0.6 years; breast maturation stages IV [n = 2], III [n = 7], and II [n = 1]) and an active control group (Con-7, n = 9; age, 12.8 ± 0.6 years; breast maturation stages IV [n = 2], III [n = 6], and II [n = 1]). In the 10th grade, subjects conformed a PJT group (Plyo-10, n = 9; age, 16.3 ± 0.5 years; breast maturation stages V [n = 5] and IV [n = 4]) and an active control group (Con-10, n = 9; age, 16.2 ± 0.5 years; breast maturation stages V [n = 5] and IV [n = 4]). Magnitude-based inferences were used for data analysis, with effect sizes (ESs) interpreted as <0.2 = trivial; 0.2–0.6 = small; 0.6–1.2 = moderate; 1.2–2.0 = large; and 2.0–4.0 = very large. The Plyo-7 and Plyo-10 showed meaningful improvements in all physical fitness measures (ES = 0.21–2.22), while Con-7 and Con-10 showed only trivial changes. The Plyo-7 and Plyo-10 showed meaningful (ES = 0.16–2.22) greater improvements in all physical fitness measures when compared with their control counterparts. The Plyo-10 showed meaningful greater improvements in 20-m sprint, 2-km running time trial, maximal strength, squat jump, and drop jump from 20 cm (ES = 0.21–0.42) when compared with Plyo-7. In conclusion, PJT is effective in improving physical fitness in younger and older female youths. However, greater adaptations were observed in more mature subjects.
The Early Hydration Characteristics of Cement-GGBS Pastes Based on Calorimetry and Electrical Resistivity Measurements
Authors: Li Binghao , Xiao Lianzhen
Published: August 2019

The hydration performance of cementitious pastes containing ground granulated blast furnace slag (GGBS) during the first 72 h was studied by the isothermal calorimeter and noncontact resistivity methods. The early electrical resistivity of the cement-GGBS pastes was higher than that of the plain cement paste because of less soluble ions in GGBS particles and higher tortuosity calculated based on the electrical resistivity. However, the cement-GGBS pastes have lower resistivity after the dissolving period, suggesting lower hydration activity of GGBS in 72 h. The hydration heat of the cement-GGBS pastes was always lower than that of the plain cement paste, and the order of the rate of hydration heat of the pastes is the same as that of the rate of the electrical resistivity; the plain specimen has the highest value, the specimens with GGBS have lower values, and the higher GGBS replacement has the lowest test results. GGBS activity in water, CH water, and cement water was investigated. The heat development of the GGBS-water mix shows the increase of 18.75 J/g from 1 to 72 h, which is much lower compared with the GGBS CH-water and GGBS cement-water mixes. The electrical resistivity results show only the dissolution process of GGBS in water. The GGBS in the CH-water solution, which was prepared with CH-to-GGBS ratios of 0.05 at a water-to-GGBS ratio of 0.5, shows obvious reaction activity; the increase value is 119.44 J/g in 72 h. The electrical resistivity shows a lower increase with time than that found with GGBS in the cement-water system. It is found that GGBS has no chemical activity in plain water and has a certain activity with CH. Cement-hydration–dominated electrical resistivity, heat development, and GGBS gave a little contribution during the hydration process. There was a good logarithmic correlation between the electrical resistivity and hydration heat during the deceleration period for the cement-GGBS specimens.
Advances in human primordial follicle activation and premature ovarian insufficiency
Authors: Ford Emmalee A , Beckett Emma L , Roman Shaun D , McLaughlin Eileen A , Sutherland Jessie M
Published: August 2019

In women, the non-growing population of follicles that comprise the ovarian reserve is determined at birth and serves as the reservoir for future fertility. This reserve of dormant, primordial follicles and the mechanisms controlling their selective activation which constitute the committing step into folliculogenesis are essential for determining fertility outcomes in women. Much of the available data on the mechanisms responsible for primordial follicle activation focuses on a selection of key molecular pathways, studied primarily in animal models, with findings often not synonymous in humans. The excessive induction of primordial follicle activation may cause the development of premature ovarian insufficiency (POI), a condition characterised by menopause before age 40 years. POI affects 1–2% of all women and is accompanied by additional health risks. Therefore, it is critical to further our understanding of primordial follicle activation in order to diagnose, treat and prevent premature infertility. Research in primordial follicle activation has focused on connecting new molecules to already established key signalling pathways, such as phosphatidylinositol 3-Kinase (PI3K) and mammalian target of rapamycin (mTOR). Additionally, other aspects of the ovarian environment, such as the function of the extracellular matrix, in contributing to primordial follicle activation have gained traction. Clinical applications are examining replication of this extracellular environment through the construction of biological matrices mimicking the 3D ovary, to support follicular growth through to ovulation. This review outlines the importance of the events leading to the establishment of the ovarian reserve and highlights the fundamental factors known to influence primordial follicle activation in humans presenting new horizons for female infertility treatment.
Pemodelan 2D Batuan Bawah Permukaan Daerah Mamuju Sulawesi Barat Dengan Menggunakan Metode Magnetik
Authors: Irsyad Muhammad , Sutrisno Sutrisno , Haryanto Dwi
Published: August 2019

Abstrak. Batuan merupakan benda yang berasal dari magma yang mendingin di dalam bumi. Untuk mengetahui kondisi batuan perlu di lakukan penelitian. Mamuju merupakan daerah yang sedang hangat dalam perbincangan peneliti tentang bagaimana kandungan di bawah permukaan daerah Mamuju, Sulawesi Barat. Daerah ini juga merupakan daerah yang diteliti oleh instansi-instansi pemerintah termasuk PTBGN-BATAN. Penelitian ini bertujuan untuk melakukan pemodelan bawah permukaan bumi. Tujuannya untuk memberikan informasi tentang kondisi baik itu bentuk maupun kedalaman batuan. penelitian ini menggunakan metode magnetik dan metode ini merupakan metode yang tepat untuk membuat model bawah permukaan bumi. Hasil interpretasi kualitatif diperoleh peta kontur intensitas magnetik total dan anomali magnetik. Peta kontur intensitas magnetik total memiliki nilai sebesar 41286,5 – 42280 nT. Sedangkan anomali magnetik memiliki nilai -760,1 – 231,8 nT. Daerah A dan daerah B merupakan daerah yang memiliki anomali tinggi. Hasil interpretasi kuantitatif didapat ada 4 model bawah permukaan yang masing-masing terdapat batuan yang sama yaitu batuan breksi dengan nilai suseptibilitas 0,0006 – 0,00075 satuan cgs dan batuan lava dengan nilai suseptibilitas 0.001 – 0.0015 satuan cgs. daerah yang dilakukan pemodelan fokus pada daerah Hulu Mamuju, hal ini disebabkan karena menurut peta kontur daerah tersebut merupakan daerah yang memiliki anomali magnetik yang tinggi.   Abstract. The rocks are objects derived from the magma cooled in the earth. To determine the condition of the rock is necessary to do research. Mamuju is an area that is warm in conversation investigators about how the content of subsurface area Mamuju, West Sulawesi. This area is also the area investigated by government agencies including PTBGN-BATAN. This study aimed to modeling subsurface. The goal is to provide information about the condition of both the shape and depth of rock. This study uses a magnetic method and this method is an appropriate method to create a model of the earth's subsurface. Qualitative interpretation of results obtained contour map of total magnetic intensity and magnetic anomalies. The total magnetic intensity contour map has a value of 41286.5 to 42280 nT. While the magnetic anomaly has a value of -760.1 - 231.8 nT. Area A and area B is an area that has a high anomaly. Results obtained quantitative interpretation there are 4 models of the subsurface that each contained the same rock is rock breccia with values susceptibility of 0.0006 to 0.00075 cgs units and lava rock with susceptibility value 0.001 - 0.0015 cgs unit. modeling area focuses on upstream area Mamuju, this is because according to the contour map of the area is an area that has a high magnetic anomaly.
Studi Teoritis Pembentukan Momen Magnetik pada Alloy half-Heusler Mn2Ge
Authors: Azhar Anugrah , Majidi Muhammad Aziz
Published: August 2019

Heusler alloyalloy is a subclass material that consists of transition metal compounds with fascinating magnetic properties due to their magnetic moment value  that is still studied by many researchers due to their magnetic moment value that can be predicted using a simple calculation called Slater-Pauling rule (SP rule)s. According to the SP rule, when the total number of the valance electron gives a value of 18 (for half-Heusler alloy), the magnetic momen of this material is predicted by the value of 0 μB. By using this simple calculation, one can make material that have zero magnetic moment value. On the other hand, those this materials generally hasve halfhalf-metallic behavior in which the spin orientation only occurs on the one direction of either in the majority or minority spin channel. Starting from those issues, we propose a theoretical study to investigate the magnetic moment formation of halfhalf-Heusler alloyalloy Mn2Ge. Our results show that Mn2Ge have magnetic moment of 0.03 μB and show the halfhalf-metallic feature of Mn2Ge.
Avaliação do manuseio de agrotóxicos, qualidade de vida, função pulmonar e marcadores bioquímicos de agricultores da região serrana do Rio Grande do Sul
Authors: Roncada Cristian , Perini Talita , Costa Daniela Duarte , Dias Caroline Pietta , Rodrigues Adriana Dalpicolli , Poeta Julia
Published: August 2019

Objetivo: Avaliar os indicadores de utilização de agrotóxicos, níveis de qualidade de vida, função pulmonar e fatores bioquímicos de agricultores de uma região serrana do sul do Brasil. Materiais e Métodos: O estudo caracteriza-se por uma pesquisa de delineamento transversal, no período de 2013 a 2015, sendo avaliados agricultores, de ambos os sexos, com idade igual ou superior a 18 anos, sendo avaliados os indicadores de manuseio e aplicação de agrotóxicos (Classes 1 a 4), utilização de equipamentos de prevenção individual (EPI), níveis de qualidade de vida, função pulmonar (volume expiratório forçado no 1º segundo; capacidade vital forçada; índice de Tiffeneau e fluxo expiratório forçado nos momentos 25 e 75%) e marcadores bioquímicos (hemograma e plaquetas, dosagens séricas de glicose, ureia, creatinina, alanina aminotransferase (ALT), aspartato aminotransferase (AST), bilirrubinas, gama-glutamiltransferase (GGT) e butirilcolinesterase – BChE). Resultados: Um total de 1.518 agricultores foram avaliados sendo 1.349 (88,9%) do sexo masculino e média de idade de 48,5±12,8 anos, de etnia 100% (n=1.518) caucasiana, com descendência da colonização italiana de 87,5% (n=1.329) e escolaridade predominante do ensino fundamental (n=887; 58,4%). Em relação a qualidade de vida, os agricultores demonstraram valores normativos dentro dos aceitáveis, sem diferenças entre o tipo de exposição aos agrotóxicos. Na função pulmonar os resultados médios também foram dentro dos preditos, com baixa prevalência para doenças pulmonares: asma 3,0% (n=46), enfisema pulmonar 2,3% (n=35) e para doença pulmonar obstrutiva crônica 1,3% (n=20). Conclusão: As variáveis analisadas apresentaram níveis aceitáveis, não tendo relações com os níveis de toxicidades ao uso de agrotóxicos.