bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of lipidomes on the risk of endometrioid endometrial cancer: a Mendelian randomization study
Authors: Lou Yaochen , Jiang Feng , Guan Jun
Published: October 2024

Objective

This study aimed to explore the potential effects between various human plasma lipidomes and endometrioid endometrial cancer (EEC) by using Mendelian randomization (MR) methods.

Methods

This study designated a total of 179 human plasma lipidomes from the genome-wide association study (GWAS) database as the exposure variable. An EEC-related dataset from the GWAS (GCST006465) served as the outcome variable. MR analyses used the inverse variance-weighted method (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods for regression calculations, accounting for possible biases induced by linkage disequilibrium and weak instrument variables. Any lipidomes failing to pass heterogeneity and horizontal pleiotropy tests were deemed to lack significant causal impact on the outcome.

Results

The results of IVW analysis disclosed that a variety of human plasma lipidomes (n = 15) exhibited a significant causal effect on EEC (p < 0.05). A subset of these lipidomes (n = 13) passed heterogeneity and horizontal pleiotropy tests, which demonstrated consistent and viable causal effects (p < 0.05) including glycerophospholipids, glycerolipids, and sterols. Specifically, phosphatidylcholine (odds ratio [OR]: 1.065-1.129, p < 0.05) exhibited a significant positive causal effect on the occurrence of EEC. Conversely, sterol ester (OR = 0.936, p = 0.007), diacylglycerol (OR = 0.914, p = 0.036), phosphatidylcholine (OR: 0.903-0.927, p < 0.05), phosphatidylethanolamine (OR = 0.907, p = 0.046) and triacylglycerol (OR: 0.880-0.924, p < 0.05) showed a notable negative causal association with EEC, suggesting their inhibitory effects on the EEC occurrence.

Conclusions

The study revealed that human plasma lipidomes have complex impacts on EEC through Mendelian randomization. This indicated that the diversity of structural changes in lipidomes could show different effects on subtypes and then affect EEC occurrence. Although these lipids had the potential to be promising biomarkers, they needed to be further clinically validated nevertheless.
Case report: A challenging case of mixed-variant myofibroblastoma with complex imaging and pathological diagnosis
Authors: Kawasaki Tomonori , Ichikawa Jiro , Kanno Satoshi , Onohara Kojiro , Wako Masanori , Tatsuno Rikito , Ochiai Satoshi , Watanabe Takuya , Torigoe Tomoaki
Published: October 2024

Myofibroblastomas are benign mesenchymal tumors that frequently occur in the groin. They show variable morphology, and the differential histopathological diagnoses are broad, including lipomatous to myxoid tumors. In addition, both pathological and imaging findings may be complex, which makes diagnosis challenging. We herein present a case of a mixed-variant myofibroblastoma of the wrist in a 73-year-old woman. Considering the long clinical course of more than 20 years and the imaging findings, a benign myxoid tumor including a schwannoma was suspected; however, the histopathological findings from resected specimens suggested a diagnosis of myxofibrosarcoma. Additional histopathological findings led to a diagnosis of mixed-variant myofibroblastoma. The differential diagnosis of myofibroblastoma extends beyond imaging to pathological findings because of the number of possible variants. This case reinforces the notion that the gold standard treatment for soft tissue tumors is to perform surgery only after determining the correct diagnosis by biopsy.
Human papillomavirus infection affects the immune microenvironment and antigen presentation in penile cancer
Authors: Guimarães Sulayne Janayna Araujo , Vale André Alvares Marques , Rocha Mirtes Castelo Branco , Butarelli Ana Luiza de Araújo , da Silva Jenilson Mota , Deus Amanda Jordão Silva de , Nogueira Leudivan , Coelho Ronald Wagner Pereira , Pereira Silma Regina , Azevedo-Santos Ana Paula Silva
Published: October 2024

Penile squamous cell carcinoma (PSCC) is a largely neglected condition, predominantly affecting underdeveloped regions, and is associated with risk factors such as low socioeconomic status, phimosis, and human papillomavirus (HPV) infection. Unlike other urogenital cancers, its pathophysiology and therapeutic targets remain poorly understood, particularly regarding the immune response to the tumor microenvironment. This study aims to investigate immune cell infiltration profiles, dendritic cell maturation, and lymphocyte apoptosis in both HPV-positive and HPV-negative PSCC. Clinical and histopathological data, along with peripheral blood and tumor tissue samples, were collected from 30 patients (66.6% were HPV-positive and 33.3% HPV-negative), with an additional 19 healthy donors serving as controls. Tumor-infiltrating immune cells were analyzed following enzymatic digestion of tumor tissue, enabling detailed phenotypic characterization. A simulated tumor microenvironment was created using supernatants derived from primary cultures of HPV-positive PSCC tumors. Peripheral blood mononuclear cells were isolated and differentiated into dendritic cells (Mo-DCs) for further phenotyping and lymphoproliferation assays. Lymphocytes from healthy donors and patients were exposed to tumor culture supernatants to evaluate apoptosis induced by the tumor microenvironment. Results showed that HPV-positive tumors exhibited lower T lymphocyte frequencies compared to HPV-negative tumors. Additionally, patients infected with high-risk HPV demonstrated reduced maturation rates of Mo-DCs and decreased expression of co-stimulatory molecules on these cells compared to healthy donors. Furthermore, Mo-DCs from hrHPV-positive patients showed impaired lymphoproliferation capacity relative to controls, while HPV-negative patients exhibited a trend towards reduced lymphoproliferative ability. Regarding the simulated tumor microenvironment, lymphocytes from healthy donors underwent apoptosis, contrasting with patients' lymphocytes, which showed increased viability when cultured with tumor supernatants. These results underscore the impact of HPV infection on T lymphocyte infiltration, Mo-DC maturation, and lymphocyte survival in PSCC, offering critical insights for advancing our understanding of the tumor microenvironment and guiding the development of immunotherapy strategies.
Antiphospholipid syndrome onset with hemolytic anemia and accompanied cardiocerebral events: a case report
Authors: Zheng Jie , Wei Zhao-Yu , Lin Shi-Chao , Wang Yong , Fang Xin
Published: October 2024

Background

Antiphospholipid syndrome (APS) is a systemic autoimmune disorder that can manifest as thrombosis in the pediatric population, characterized by persistently positive antiphospholipid antibodies. APS is infrequently observed in children and could represent non-criteria manifestations.

Case presentation

A six-year-old Chinese female presented with jaundice and dark urine, leading to a diagnosis of hemolytic anemia. Prednisone therapy initially improved her complexion, but she later developed neurological symptoms. Further laboratory tests showed intravascular hemolysis, coagulation abnormalities, and a positive lupus anticoagulant (LA) test result. Magnetic resonance imaging (MRI) scan revealed abnormal signals in the pons and cerebellar hemispheres, and an occluded part of the basilar artery. She was subsequently diagnosed with autoimmune encephalitis and received IG(immunoglobulin) and high-dose glucocorticoid (GC) treatment, leading to improvement in her clinical symptoms. However, the symptoms of hemolytic anemia worsened after two years. Subsequent laboratory assessments demonstrated the presence of intravascular hemolysis, coagulation abnormalities, and positive tests of anticardiolipin, LA, and anti-beta2 glycoprotein I antibodies. Elevated troponin I and N-terminal pro-brain natriuretic peptide levels, along with electrocardiogram and echocardiogram findings, indicated a myocardial infarction and a thrombus-like mass in the left auricle. Brain MRI showed multifocal infarction and cerebrovascular obstruction. She was diagnosed with APS accompanied by hemolytic anemia, cerebrovascular obstruction, and myocardial infarction. After several weeks of treatment with GC, IG, rituximab, hydroxychloroquine alone with low-molecular-weight heparin sodium, and warfarin, there was a marked improvement in the patient's condition.

Conclusion

Pediatricians should be familiar with various presentations of pediatric APS to promptly detect possible aPL-related complications and initiate appropriate management strategies early on.
Comparison of sGC activator and sGC stimulator in 5/6 nephrectomized rats on high-salt-diet
Authors: Chen Xin , Xiong Yingquan , Zeng Shufei , Delić Denis , Gaballa Mohamed , Kalk Philipp , Klein Thomas , Krämer Bernhard K. , Hocher Berthold
Published: October 2024

Introduction

Soluble guanylate cyclase (sGC) stimulators and activators are known to enhance kidney function in various models of chronic kidney disease (CKD) by increasing cyclic guanosine monophosphate (cGMP). Their differential effects on CKD progression, particularly under conditions of oxidative stress, remain unexplored by direct comparative studies.

Methods

We conducted a side-by-side comparison using 5/6 nephrectomized rats on a high salt diet (5/6Nx+HSD) to evaluate the efficacy of the sGC stimulator BAY 41–8543 and the sGC activator BAY 60–2770 in CKD progression. BAY 41–8543 (1 mg/kg; twice daily) and BAY 60–2770 (1 mg/kg; once daily) were administered by gavage for 11 weeks.

Results

The 5/6Nx+HSD model led to increased plasma creatinine, proteinuria, and blood pressure. Both BAY 41–8543 and BAY 60–2770 significantly reduced systolic and diastolic blood pressure to a similar extent but did not improve renal function parameters. Notably, BAY 60–2770 reduced renal fibrosis, including interstitial fibrosis and glomerulosclerosis, whereas BAY 41–8543 did not. These antifibrotic effects of BAY 60–2770 were independent of blood pressure reduction. Proteomic analysis revealed that BAY 60–2770 corrected the upregulation of 9 proteins associated with apoptosis and fibrosis, including Caspase-3, MKK6 (Mitogen-Activated Protein Kinase Kinase 6), Prdx5 (Peroxiredoxin-5), in the 5/6Nx+HSD group.

Discussion

In contrast, BAY 41–8543 had no significant impact on these proteins. sGC activators were more effective than sGC stimulators in reducing renal fibrosis in 5/6 nephrectomized rats on a high salt diet, and this effect was due to modulation of apoptosis-associated proteins beyond the control of blood pressure.
Electronic 1/f noise as a probe of dimensional effects on spin-glass dynamics
Authors: Harrison David C.
Published: October 2024

Over the past decade, spin-glass simulations have improved to the point that they now access time- and length-scales comparable to experiments at the mesoscale. A recent series of thin-film field-cooled/zero-field-cooled magnetization (FC/ZFC) experiments demonstrated activated spin dynamics, with a temperature-independent activation energy proportional to the logarithm of the film thickness and with coefficients in remarkable agreement with the simulation. These measurements require the application of small magnetic fields, which has been shown to affect the spin-glass energy landscape. Measurements of the 1/f noise in metallic spin-glasses have been previously shown to be a sensitive probe of the spin dynamics, and the measurements can be made without applying a magnetic field. In this mini-review, we review these techniques and discuss how transport measurements can fit into the current landscape of spin-glass measurements. We compare previous measurements to more recent measurements on similar films, made with ostensibly different cooling protocols, and compare both the previous and recent measurements to the magnetometry. The transport measurements—taken over a wider range of temperature than magnetometry—suggest that the maximum spin-glass energy barrier height is temperature-dependent, not fixed, possibly due to two-dimensional dynamics. We discuss this possibility, along with future measurements, which may be able to resolve this mystery.
Current oral contraceptive use affects explicit and implicit measures of depression in women
Authors: Hampson Elizabeth , Abrahamson Sara N. , Breddy Taylor N. , Iqbal Maisha , Wolff Elena R.
Published: October 2024

Some data suggest that increased depressive symptoms may occur in women using combined oral contraceptives (OCs). However, this idea is controversial and the existing evidence is conflicting. The present study compared negative affect in 53 healthy women (Mage = 19.9 years) during intervals of active daily OC hormone intake and during the washout week of the contraceptive cycle when no exogenous estrogens or progestins are used. A prospective counterbalanced repeated-measures study design was employed. Depressive affect was evaluated using standard psychometric tests of explicit (self-perceived) and implicit negative affect. Implicit measures are considered less subject to bias related to social expectations, self-awareness, or willingness to disclose. Other than their usual OCs, participants were medication-free and had been using OCs for a median of 12 mo. We found that measures of implicit affect (e.g., Affect Misattribution Procedure, Emotional Stroop Test) displayed a more depressive-like pattern of performance during active hormone intake, particularly among a subgroup of OC users who reported experiencing high levels of depressive affect more generally. In contrast, participants’ self-perceptions suggested that they perceived their negative symptoms to be greater during the ‘off’ phase of the OC cycle, when OC steroids are withdrawn and menses occurs. The present findings reinforce the possibility of depressive mood effects associated with OC usage, and highlight the utility of including implicit measures, but also illustrate the complexity of mood assessment in OC users.
Beyond the walls of the classroom: the psychodynamics of professional commitment and job involvement among female primary school teachers
Authors: Su Qiaolan
Published: October 2024

This research used structural equation modeling (SEM) to explore the relationship between professional commitment, self-efficacy, psychological resilience, perceived organizational support and job involvement of female teachers in Chinese primary schools. The purpose of the study was to understand how these psychological and organizational factors work together on teachers’ job involvement. Based on the questionnaire survey of 596 female teachers in primary schools, the data were collected and analyzed by AMOS software. The results show that professional commitment plays a central role in teachers’ job involvement, and self-efficacy and psychological resilience, as important psychological resources, significantly affect job involvement through the mediation of perceived organizational support. The model fitting indicators CFI, RMSEA and SRMR were in line with the acceptance criteria, which verified the adaptability of the hypothesis model. The findings not only reinforce the application of resource conservation theory in the field of education, but also provide school administrators with strategies to improve teachers’ job involvement, especially by enhancing the importance of organizational support and resilience. In addition, the results have practical implications for the design of targeted teacher professional development programs.
A novel missense mutation in ISCA2 causes aberrant splicing and leads to multiple mitochondrial dysfunctions syndrome 4
Authors: Al-Hassnan Zuhair , AlDosary Mazhor , AlHargan Aljouhra , AlQudairy Hanan , Almass Rawan , Alahmadi Khaled Omar , AlShahrani Saif , AlBakheet Albandary , Almuhaizea Mohammad A. , Taylor Robert W. , Colak Dilek , Kaya Namik
Published: October 2024

Background

Iron–sulfur cluster assembly 2 (ISCA2) deficiency is linked to an autosomal recessive disorder known as multiple mitochondrial dysfunctions syndrome 4 (MMDS4). This disorder is characterized by leukodystrophy and neuroregression. Currently, most of the reported patients are from Saudi Arabia. All these patients carry a homozygous founder variant (NM_194279.2:c.229G>A:p.Gly77Ser) in ISCA2.

Methods

We describe a patient who underwent full clinical evaluation, including metabolic, neurological, and radiological examinations. Standard genetic testing, including whole exome sequencing coupled with autozygome analysis, was undertaken, as were assessments of mitochondrial DNA (mtDNA) copy number and mtDNA sequencing on DNA extracted from blood and cultured fibroblasts. Functional workup consisted of splicing assessment of ISCA2 using RT-PCR, biochemical assessment of complex I status using dipstick assays, and mitochondrial respiration measurements using a Seahorse XFp analyzer.

Results

We present the clinical and functional characterization of a novel homozygous ISCA2 missense variant (NM_194279.3:c.70A>G:p.Arg24Gly), leading to aberrant splicing in a patient presenting with neuroregression, generalized spasticity with exaggerated deep tendon reflexes and head lag, and progressive loss of acquired milestones. The novel variant was fully segregated in a wider family and was absent in a large control cohort, ethnically matching in-house exomes, local databases such as CGMdb and Saudi Human Genome Program, and ClinVar.

Conclusions

Our analyses revealed that the variant is pathogenic, disrupting normal ISCA2 splicing and presumably leading to a truncated protein that disturbs metabolic pathways in patient-derived cells.
More knowledge, more choices? How peer recognition of physicians’ knowledge sharing affect patients’ consultation in online health communities
Authors: Xu Zhen , Liu Xiaochen , Meng Lingguang , Lyu Xuanxuan
Published: October 2024

Background

The advent of telemedicine has revolutionized healthcare consultations, primarily due to the digital era and global health concerns. Online healthcare communities (OHCs) have emerged as platforms for physicians to share health-related articles, promoting digital public health awareness and knowledge dissemination. The continuous dissemination of health knowledge by physicians online is considered a crucial driving force in attracting patients to seek online consultations.

Methods

Based on the elaboration likelihood model and the information overload theory, this study explores how persuasive messages from other patients’ peer recognition, including knowledge popularity and attractiveness, affect patients’ consultation decisions. Additionally, the study examines the three-way interaction between knowledge popularity, attractiveness, and quantity in shaping patient consultations. Using data collected from 2,676 physicians on haodf.com, this study established an ordinary least squares (OLS) regression model with time and city fixed effects to test the hypothesis.

Results

The results show that: (1) peer recognition (knowledge popularity and attractiveness) from other patients positively impacts patients’ consultation; (2) knowledge attractiveness positively moderate the relationship between knowledge popularity and patients’ consultation; (3) there is a three-way effect of knowledge popularity, knowledge attractiveness, and knowledge quantity on patients’ consultation.

Conclusion

Our findings offer valuable guidance for platform design and healthcare practitioners, boosting patient-physician engagement in online healthcare communities.
Determinants of medication non-adherence among patients with chronic diseases at community pharmacy settings in South Gondar Zone, Northwest Ethiopia: a multicenter cross-sectional study
Authors: Moges Tilaye Arega , Dagnew Samuel Berihun , Wondm Samuel Agegnew , Ferede Yared Andargie , Yiblet Tesfagegn Gobezie , Almaw Andargachew , Shumet Yimer Yohannes , Tesfaw Addis Getu , Zewdu Woretaw Sisay , Dagnew Fisseha Nigussie
Published: October 2024

Background

Medication non-adherence is a significant public health concern in managing patients with chronic diseases, and community pharmacists are on the frontline in the management of chronic medications. Chronic diseases require lifelong pharmacotherapy and understanding the determinants of medication adherence has paramount importance to develop strategies that improve medication adherence and treatment outcomes. Thus, this study aimed to assess the magnitude of medication non-adherence and its contributing factors among patients with chronic diseases attending community pharmacies in South Gondar Zone, Northwest Ethiopia.

Methods

A multicenter cross-sectional study was conducted at community pharmacies in South Gondar Zone from September 01 to October 30, 2023. Medication adherence was assessed using a structured questionnaire using the Adherence in Chronic Diseases Scale (ACDS). Statistical Package for Social Sciences (SPSS) version 25 was used for analysis. Association between the outcome variable and independent variables was performed using binary logistic regression and a p-value of <0.05 was considered statistically significant.

Results

Among three hundred and eighty six (386) study participants recruited in this study, more than half of them 222 (57.51%, 95%CI: 52.4% - 62.5%) were low adherent to their medications. Concerning determinants of medication non-adherence; the presence of side effects (AOR =2.1, 95%CI=1.33-3.29), unable to get ever counseling from community pharmacists (AOR=2.3, 95%CI= 1.46-3.58), and poor about their medications (AOR=3.1, 95% CI= 1.96-4.82) were significantly associated with patients’ non-adherence to medications.

Conclusion

The medication adherence level in this study was suboptimal, with a significant proportion of the patients being non-adherent to their medications. The presence of side effects, unable to get ever counseling, and poor knowledge about their medications were statistically significant factors of poorer medication adherence. Hence, healthcare professionals, especially community pharmacists, have a crucial role in designing the schedule for health education concerning the needs of these patients in community pharmacy settings.
Impact of caring for patients with polyhandicap on institutional health care workers’ quality of life: a cross-sectional and longitudinal evaluation
Authors: Rousseau Marie-Christine , Beltran Any , Hamouda Ilyes , Aim Marie-Anastasie , Felce Agnès , Lind Katia , Khaldi Nafissa , El Ouazzani Houria , Auquier Pascal , Villemeur Thierry Billette de , Baumstarck Karine
Published: October 2024

Background

Profound intellectual multiple disabilities or polyhandicap (PLH) is defined as a combination of profound mental retardation and serious motor deficits resulting in extreme dependence. Support for these patients is multidisciplinary, complex, and time-consuming. Thus, institutional health care workers (HCWs) face specific working conditions: frequent physical tasks, distressed families, and restricted feedback.

Objectives

We aimed to identify determinants of quality of life (QoL) of HCWs and to study longitudinal evolution.

Methods

The study used data from the French cohort EVAL-PLH. The participants were institutional HCWs of persons with PLH (age ≥ 3 years at the time of inclusion; age at onset of cerebral lesion <3 years old). Two populations were used: (1) cross sectional study: the sample 1 includes the HCWs assessed at T2 (2020–2021); (2) longitudinal study: the sample 2 includes the HCWs assessed at both T1 (2015–2016) and T2 (2020–2021). The data collected included: sociodemographics, health status, professional variables, and psycho-comportemental aspects. QoL was assessed using WHOQOL-BREF which provides 4 scores.

Results

In comparison with French norms, the physical and social scores of QoL were significantly lower while the psychological score was significantly higher for (i) the 223 HCWs (participation rate 62%) assessed at T2 and (ii) the 61 HCWs assessed at T1 and T2. The main factors modulating QoL were age, marital status, self-perceived financial difficulties, personal chronic disease, anxiety-mood disorders, nature of coping strategies, and burnout.

Conclusion

This study confirms the mixed (negative and positive) impact of caring persons with PLH on the institutional HCWs’ QOL. Main determinants of the HCW’s QOL were: older age, single status, perceived financial difficulties, altered health status, burn out and coping strategies.

Clinical trial registration number: NCT02400528.
Long-term-survival phase cells of Salmonella enteritidis ATCC 13076 exhibit significantly greater tolerance to atmospheric cold plasma treatment of shell eggs
Authors: Barry Kia , Mendonça Aubrey , Phillips Gregory J. , Boylston Terri , Fortes-Da-Silva Paulo , Brehm-Stecher Byron , Juneja Vijay , Wan Zifan
Published: October 2024

The main objective of this study was to evaluate the tolerance of stationary phase (STAT) and long-term survival phase (LTS) Salmonella Enteritidis ATCC 13076 to atmospheric cold plasma (ACP) in phosphate buffered saline (PBS, pH 7.0) and on shell eggs. Salmonella Enteritidis was cultured in tryptic soy broth supplemented with 0.6% (w/v) yeast extract (35°C) for 20 h (STAT) and 21 days (LTS). Cell morphology was determined by light microscopy. The PBS and shell eggs were inoculated with STAT or LTS cells to obtain ∼7.0 log10 CFU/mL or egg. The ACP was applied at 45 kV (PBS) and 60 kV (shell eggs) for 1–4 min and 1–5 min, respectively. Pathogen survivors were enumerated on thin agar layer (TAL) medium and on xylose lysine tergitol-4 (XLT-4) agar after 48 h of incubation (35°C). For survivors on shell eggs, R2 and mean square error values were obtained using Log-linear with Tail and Weibull models. The STAT cells were predominantly rod-shaped whereas LTS cells were coccoid. In PBS, reductions (log10 CFU/mL) of STAT cells were 1.0, 0.95, 1.45, and 1.44 after exposure to ACP for 1, 2, 3, and 4 min, respectively. In contrast, reductions in LTS cells were significantly lower (p< 0.05) at 0.04 (1 min), 0.06 (2 min) 0.01 (3 min), and 0.11 (4 min). A similar pattern was observed for shell eggs whereby LTS cells exhibited much higher tolerance to ACP than STAT cells (p < 0.05). The Log-linear with Tail model produced a better fit of the survival data for STAT cells; times to achieve a 4- and 5- log reduction were 5.29 and 5.78 min, respectively. Sub-lethal injury occurred in both STAT and LTS survivors; however, differences were not significant (P > 0.05). Additionally, there were no observed differences in shell strength and yolk color between ACP-treated and control eggs. Based on these results, LTS cells of S. Enteritidis are more tolerant to ACP than STAT cells and should be considered when developing process validation protocols involving application of ACP to inactivate Salmonella on shell eggs.
Tumor therapeutics in the era of “RECIST”: past, current insights, and future prospects
Authors: Xu Zhilong , Jiang Gening , Dai Jie
Published: October 2024

In recent years, advancements in medical treatment and imaging technologies have revolutionized the assessment of tumor response. However, the Response Evaluation Criteria in Solid Tumors (RECIST) has long been established as the gold standard for evaluating tumor treatment. As treatment modalities evolve, the need for continuous refinement and adaptation of RECIST becomes increasingly apparent. This review explores the historical evolution, current applications, limitations, and future directions of RECIST. It discusses the challenges of distinguishing true progression from pseudo-progression in ICIs (immune checkpoint inhibitors), the integration of advanced imaging tools, and the necessity for RECIST criteria tailored to specific therapies like neoadjuvant treatments. The review highlights the ongoing efforts to enhance RECIST’s accuracy and reliability in clinical decision-making and the potential for developing new standards to better evaluate treatment efficacy in the rapidly evolving landscape of oncology.
Noise Study Auralization of an Open-Rotor Engine
Authors: Zhang Qing , Jiang Siyi , Yang Xiaojun , Xu Yongjia , Zhu Maosheng
Published: October 2024

Based on the performance and acoustic data files of reduced-size open-rotor engines in low-speed wind tunnels, the static sound pressure level was derived by converting the 1-foot lossless spectral density into sound-pressure-level data, the background noise was removed, and the results were corrected according to the environmental parameters of the low-speed wind tunnels. In accordance with the requirements of Annex 16 of the Convention on International Civil Aviation Organization and Part 36 of the Civil Aviation Regulations of China on noise measurement procedures, the takeoff trajectory was physically modeled; the static noise source was mapped onto the takeoff trajectory to simulate the propagation process of the noise during takeoff; and the 24 one-third-octave center frequencies that corresponded to the SPL data were corrected for geometrical dispersion, atmospheric absorption, and Doppler effects, so that the takeoff noise could be corrected to represent a real environment. In addition, the audible processing of noise data with a 110° source pointing angle was achieved, which can be useful for enabling practical observers to analyze the noise characteristics.
The Degradation of Polyethylene by Trichoderma and Its Impact on Soil Organic Carbon
Authors: Zhu Lixia , Chen Yaqin , Ni Wenke , Zeng Jiaxuan , Li Xin , Hu Chunhong , Li Lili
Published: October 2024

Polyethylene mulching film, which is widely utilized in arid and semi-arid agriculture, leaves residual pollution. A novel approach to addressing this issue is microbial degradation. To screen the strains that degrade polyethylene efficiently and clarify the effect of degrading strains on the turnover of soil organic carbon, a polyethylene-degrading fungus PF2, identified as Trichoderma asperellum, was isolated from long-time polyethylene-covered soil. Strain PF2 induced surface damage and ether bonds, ketone groups and other active functional groups in polyethylene, with 4.15% weight loss after 30 days, where laccase plays a key role in the degradation of polyethylene. When applied to soil, the Trichoderma-to-soil weight ratios were the following: B1: 1:100; B2: 1:200; B3: 1:300 and B4: 1:400. Trichoderma asperellum significantly increased the cumulative CO2 mineralization and soil organic carbon mineralization in the B1 and B2 treatments compared with the control (B0). The treatments B1, B3 and B4 increased the stable organic carbon content in soil. An increase in the soil organic carbon content was observed with the application of Trichoderma asperellum, ranging from 27.87% to 58.38%. A positive correlation between CO2 emissions and soil organic carbon was observed, with the soil carbon pool management index (CPMI) being most correlated with active organic carbon. Trichoderma treatments improved the CPMI, with B3 showing the most favorable carbon retention value. Thus, Trichoderma asperellum not only degrades polyethylene but also contributes to carbon sequestration and soil fertility when applied appropriately.
Detection and Early Warning of Duponchelia fovealis Zeller (Lepidoptera: Crambidae) Using an Automatic Monitoring System
Authors: Rodríguez-Vázquez Edgar , Hernández-Juárez Agustín , Reyes-Rosas Audberto , Illescas-Riquelme Carlos Patricio , Lara-Viveros Francisco Marcelo
Published: October 2024

In traditional pest monitoring, specimens are manually inspected, identified, and counted. These techniques can lead to poor data quality and hinder effective pest management decisions due to operational and economic limitations. This study aimed to develop an automatic detection and early warning system using the European Pepper Moth, Duponchelia fovealis (Lepidoptera: Crambidae), as a study model. A prototype water trap equipped with an infrared digital camera controlled using a microprocessor served as the attraction and capture device. Images captured by the system in the laboratory were processed to detect objects. Subsequently, these objects were labeled, and size and shape features were extracted. A machine learning model was then trained to identify the number of insects present in the trap. The model achieved 99% accuracy in identifying target insects during validation with 30% of the data. Finally, the prototype with the trained model was deployed in the field for result confirmation.
Classification and Evaluation of Marginal Land for Potential Cultivation in Northwest China Based on Contiguity and Restrictive Factors
Authors: Zhang Ailin , Wang Sheliang , Zhang Zipei , Niu Jiacheng , Guo Mengyu , Ye Huichun , Guo Xingtao , Su Ruizhe , Tang Huaizhi
Published: October 2024

Water, land, and other environmental conditions restrict marginal land (ML) conversion into newly cultivated land. Accurately evaluating ML’s development and utilization potential (DUP) can provide critical support for increasing new cultivated land and ensuring food security. This study focuses on Northwest China, using spatial identification of different types of ML based on remote sensing images, and constructs a county-level DUP evaluation model through contiguous characteristics and restrictive factors to determine new cultivated-land potential, water demand, and liftable grain production. The results show that the DUP of ML in Northwest China is 12.59 million ha, with low-efficiency cultivated land (LCL) and two types of restoration land (TTRL) accounting for 3.29% and 5.95%, and other marginal land (OML) making up 90.76%. The total water demand for ML development and utilization is 69.87 billion cubic meters, which can increase grain production by 62.31 million tons. The coordinated development of water, land, and food promotes an increase in grain production, with water resources being the main restrictive factor. This model effectively evaluates DUP and provides a scientific basis for promoting the rational use of water and land resources. Further research should set up more detailed water resource utilization strategies and scenarios as well as find more development and utilization techniques.
Assessment of the Impact of Dietary Supplementation with Epigallocatechin Gallate (EGCG) on Antioxidant Status, Immune Response, and Intestinal Microbiota in Post-Weaning Rabbits
Authors: Yin Dafei , Zhang Zhan , Zhu Yanli , Xu Ze , Liu Wanqin , Liang Kai , Li Fangfang
Published: October 2024

This study was conducted to investigate the impact of EGCG on antioxidant stress, immune response, and intestinal microbiota flora in post-weaning rabbits. A total of 144 40 d Ira rabbits (equally divided by sex), were randomly allocated to six treatments. with five groups receiving doses of 200, 400, 600, 800, and 1000 mg/kg of EGCG, while one group served as a control without EGCG. Over 48 days, this study the assessed growth performance, antioxidant capacity, immune system, intestinal morphology, and cecal microbiota in the rabbits. The results showed that EGCG did not affect growth performance; however, significant linear and quadratic correlations were observed between the MDA, T-AOC, and GSH-Px activities in the liver and jejunum (p < 0.05). Quadratic effects were observed for the spleen and thymus indexes and serum IgG levels with increasing EGCG dosages (p < 0.05). Additionally, positive linear and quadratic effects were found on the ileal villus height and the villus height/crypt depth ratio. The relative abundances of Euryarchaeota, Patescibacteria, and Synergistota were significantly enriched in rabbits fed with high dosages (600–1000 mg/kg) of EGCG. Conclusively, the addition of large doses of EGCG (400–800 mg/kg) can effectively suppress oxidative stress and alleviate weaning stress, thereby contributing to the protection of post-weaning rabbits.
Wildlife–Vehicle Collisions and Mitigation: Current Status and Factor Analysis in South Korea
Authors: Hwang Ju-Won , Jo Yeong-Seok
Published: October 2024

Severe habitat loss and fragmentation due to extensive road development have escalated wildlife–vehicle collisions (WVCs) as one of the major causes of wildlife mortality. This study, spanning 9 years from 2009 to 2017, presents comprehensive WVC data in South Korea, including species composition, seasonal and regional patterns, and road factors influencing WVCs, aiming to analyze their impact and propose effective mitigation strategies. We collected WVC data with road variables for 9 years from 4561 km of nationwide monitoring road sections and analyzed the data to understand the relationship between WVCs and road characteristics, as well as species-specific patterns. A nationwide survey identified 13,606 WVCs involving 143 terrestrial vertebrate species, and patterns and models of the top seven mammal species (raccoon dog (Nyctereutes procyonoides), Siberian chipmunk (Eutamias sibiricus), Siberian weasel (Mustela sibirica), water deer (Hydropotes inermis), red squirrel (Sciurus vulgaris), Korean hare (Lepus coreanus), and leopard cat (Prionailurus bengalensis)) were presented. Patterns revealed declines in WVCs overall, except for water deer. Although spatial differences in WVCs seemed linked more to wildlife habitats, certain road features correlated both positively or negatively with WVC frequency, highlighting complexities in the effectiveness of preventative measures. For effective mitigation and prevention of WVCs, comprehensive strategies considering species traits, seasonality, and road types should be implemented
Machine Learning for the Genomic Prediction of Growth Traits in a Composite Beef Cattle Population
Authors: Hay El Hamidi
Published: October 2024

The adoption of genomic selection is prevalent across various plant and livestock species, yet existing models for predicting genomic breeding values often remain suboptimal. Machine learning models present a promising avenue to enhance prediction accuracy due to their ability to accommodate both linear and non-linear relationships. In this study, we evaluated four machine learning models—Random Forest, Support Vector Machine, Convolutional Neural Networks, and Multi-Layer Perceptrons—for predicting genomic values related to birth weight (BW), weaning weight (WW), and yearling weight (YW), and compared them with other conventional models—GBLUP (Genomic Best Linear Unbiased Prediction), Bayes A, and Bayes B. The results demonstrated that the GBLUP model achieved the highest prediction accuracy for both BW and YW, whereas the Random Forest model exhibited a superior prediction accuracy for WW. Furthermore, GBLUP outperformed the other models in terms of model fit, as evidenced by the lower mean square error values and regression coefficients of the corrected phenotypes on predicted values. Overall, the GBLUP model delivered a superior prediction accuracy and model fit compared to the machine learning models tested.
Vitamin C in the Management of Thyroid Cancer: A Highway to New Treatment?
Authors: Gorini Francesca , Tonacci Alessandro
Published: October 2024

Thyroid cancer (TC) is the most common endocrine malignancy, with an increased global incidence in recent decades, despite a substantially unchanged survival. While TC has an excellent overall prognosis, some types of TC are associated with worse patient outcomes, depending on the genetic setting. Furthermore, oxidative stress is related to more aggressive features of TC. Vitamin C, an essential nutrient provided with food or as a dietary supplement, is a well-known antioxidant and a scavenger of reactive oxygen species; however, at high doses, it can induce pro-oxidant effects, acting through multiple biological mechanisms that play a crucial role in killing cancer cells. Although experimental data and, less consistently, clinical studies, suggest the possibility of antineoplastic effects of vitamin C at pharmacological doses, the antitumor efficacy of this nutrient in TC remains at least partly unexplored. Therefore, this review discusses the current state of knowledge on the role of vitamin C, alone or in combination with other conventional therapies, in the management of TC, the mechanisms underlying this association, and the perspectives that may emerge in TC treatment strategies, and, also, in light of the development of novel functional foods useful to this extent, by implementing novel sensory analysis strategies.
Correction: Xu et al. Use of Optical Redox Imaging to Quantify Alveolar Macrophage Redox State in Infants: Proof of Concept Experiments in a Murine Model and Human Tracheal Aspirates Samples. Antioxidants 2024, 13, 546
Authors: Xu He N. , Gonzalves Diego , Hoffman Jonathan H. , Baur Joseph A. , Li Lin Z. , Jensen Erik A.
Published: October 2024

In the original publication [...]
Role of Callistemon citrinus Leaf Phytosomes Against Oxidative Stress and Inflammation in Rats Fed with a High-Fat-Fructose Diet
Authors: Ortega-Pérez Luis Gerardo , Hernández-Soto José Armando , Padilla-Avalos Osvaldo , Ayala-Ruiz Luis Alberto , Magaña-Rodríguez Oliver Rafid , Piñón-Simental Jonathan Saúl , Aguilera-Méndez Asdrúbal , Godínez-Hernández Daniel , Rios-Chavez Patricia
Published: October 2024

Phytosomes are used as vehicles that carry plant extracts. They exhibit biological activities and possess better bioavailability, bioabsorption, and lower toxicity than drugs. Obesity is an inflammatory state in which oxidative stress is present, which triggers severe effects on the body’s organs. This study aimed to evaluate the impact of the extract and phytosomes of Callistemon citrinus on oxidative stress and inflammation in the liver and heart of Wistar rats fed with a high-fat-fructose diet. Phytosomes containing the extract of leaves of C. citrinus were prepared. The antioxidant, pro-inflammatory enzymes, and biomarkers of oxidative stress were evaluated. Among the groups, only the high-fat-fructose group presented an increase in the COX-2, 5-LOX, and MPO inflammatory enzymes, while the XO enzyme exhibited decreased activity. The groups were fed a hypercaloric diet for 15 weeks while orlistat, C. citrinus extract, and phytosomes were administered at three different concentrations, exhibiting enzyme activities similar to those of the control group. It was also observed that the lowest concentration of phytosomes had a comparable effect to the other concentrations. Callistemon citrinus extract can modulate the activities of enzymes involved in the inflammation process. Furthermore, small doses of phytosomes can serve as anti-inflammatory agents.
The Mechanism of Tendentious Information Dissemination in Cyberspace
Authors: Zong Teng , Chen Bing , Wang Fengsi , Wei Xin , Liu Yibo , Hu Zongmin , Li Taowei
Published: October 2024

Cyberspace has evolved into a hub for the dissemination of large amounts of tendentious information, posing significant challenges to the role of mainstream value information. As netizens’ are the main recipients of tendentious information, their personal cognition, attitude, and behavioral ability affect their willingness to re-disseminate information, making them an inalienable force in the promotion of information dissemination. Exploring the dissemination mechanism of tendentious information in cyberspace can help to understand the law of information dissemination and predict the trend of information diffusion, which is of great significance to maintaining information security and social stability. However, the existing research has overlooked the potential influence of the attribute characteristics of information in terms of content, and has failed to overcome the methodological constraints of traditional statistical analysis to accurately describe the variables and mechanisms influencing the dissemination of tendentious information at the cognitive level. Therefore, using structural equation modeling, we propose a research index system based on the Theory of Planned Behavior and the characteristics of tendentious information. To this end, confirmatory factor and model fitting analyses were conducted to develop a tendentious information dissemination mechanism model, which we validated through testing and comparative experiments. Path analysis revealed that Attitude Toward Dissemination, Information Dissemination Intention, and Information Dissemination Behavior are the main links in the information dissemination process. Moreover, Information Sentiment Orientation was found to strongly promote the dissemination of tendentious information, while Subject Norm of Dissemination had a minor inhibiting effect.
The Direct Impact Effect of Different Foot Orthotic Designs on the Plantar Loading of Patients with Structural Hallux Limitus: A Quasi-Experimental Study
Authors: Martinez-Rico Magdalena , Gijon-Nogueron Gabriel , Ortega-Avila Ana Belen , Roche-Seruendo Luis Enrique , Climent-Pedrosa Ana , Sanchis-Sales Enrique , Deschamps Kevin
Published: October 2024

Background: This study examines the effect of two types of custom-made foot orthoses (CFOs) in patients with structural hallux limitus (SHL). Methods: In this quasi-experimental, repeated measures study, 24 participants with SHL were sampled. Two CFOs—cut-out CFO and anterior stabilizer element (AFSE) CFO—were compared using minimalist SAGURO neoprene shoes: no foot orthoses (FO), cut-out CFO, and AFSE CFO. Plantar pressures and center of pressure (CoP) displacement were measured using a Podoprint® platform. Results: Both CFOs shifted the CoP medially during midstance (p < 0.001 with AFSE CFO and p = 0.0036 with cut-out CFO). The AFSE CFO showed a more anterior CoP in midstance, while the cut-out CFO affected anterior CoP in midstance and pre-swing. The AFSE CFO significantly increased pressure in the second toe, lesser metatarsal heads (MTH), midfoot, and rearfoot. In contrast, the cut-out CFO decreased pressure in the second MTH and lesser toe regions, increasing pressure in the midfoot and heel. Both CFOs lowered the hallux/first MTH ratio compared to shod without CFO. Conclusions: The cut-out CFO led to medial and anterior CoP displacement, reducing lateral foot and hallux pressure while transferring loads to the first MTH. The AFSE CFO caused a similar shift by increasing loads on the first MTH.
Quinolone and Tetracycline-Resistant Biofilm-Forming Escherichia coli Isolates from Slovak Broiler Chicken Farms and Chicken Meat
Authors: Dančová Nikola , Gregová Gabriela , Szabóová Tatiana , Regecová Ivana , Király Ján , Hajdučková Vanda , Hudecová Patrícia
Published: October 2024

Escherichia coli isolates from intensive poultry production are associated with antimicrobial resistance and worldwide health problems. The aim of the study was to detect and evaluate the phenotypic and genotypic antimicrobial resistance, biofilm formation, phylogenetic typing, and virulence factors in E. coli isolates from the rectal swabs of chickens from two farms and swabs of chicken meat purchased from Slovakian food markets. Interpretative readings of minimal inhibitory concentration (MIC) revealed dominant resistance to ampicillin (>50%) in both groups. We also detected higher resistance to ciprofloxacin (45%), tetracycline, ampicillin + sulbactam, and trimethoprim + sulfonamide (each >30%). Here, 28.57% of the strains studied were multidrug-resistant (MDR). The formation of weak biofilms was confirmed in 8.8% of E. coli, while one of the strains obtained from chicken cloacal swabs was classified as a strong biofilm producer. The most frequently confirmed phylogenetic groups in E. coli were B1 and A1 in all groups. PCR detection revealed the presence of genes encoding tetracycline resistance (tetAB) and plasmid-mediated quinolone resistance (qnrABS), and Int1 (52.9%), Tn3 (76.5%), kpsMT II (8.8%), fimA (97.1%), cvaC (38.2%), and iutA (76.5%) genes in the strains studied. Our results demonstrate that chickens and chicken meat were the source of antibiotic-resistant, biofilm-forming, and virulent E. coli, representing a potential risk from the point of view of the One Health concept.