bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Assessment Using Early Quantitative Chest CT Parameters for the Severity of COVID-19
Authors: Ding Xun , Xu Jia , Xu Haibo , Zhou Jun , Long Qingyun
Published: September 2021

Background: Today, the outbreak of coronavirus disease 2019 (COVID-19) is known as a public health emergency by the World Health Organization (WHO). Therefore, risk assessment is necessary for making a correct decision in disease management. Objectives: This study aimed to assess the risk of progression to the critical stage in COVID-19 patients, based on the early quantitative chest computed tomography (CT) parameters. Patients and Methods: In this case-control study, 39 laboratory-confirmed critical or expired COVID-19 cases (critical group), as well as 117 laboratory-confirmed COVID-19 patients including mild, moderate, and severe cases (non-critical group), were enrolled. Seven quantitative CT parameters, representing the lung volume percentages at different density intervals, were automatically calculated, using the artificial intelligence (AI) algorithms. Multivariable-adjusted logistic regression models, based on the quantitative CT parameters, were established to predict the adverse outcomes (critical vs. non-critical). The predictive performance was estimated using the receiver operating characteristic (ROC) curve analysis and by measuring the area under the ROC curve (AUC). The quantitative CT parameters in different stages were compared between the two groups. Results: No significant differences were found between the two groups regarding the lung volume percentages at different density intervals within 0 - 4 days (P = 0.596-0.938); however, this difference began to become significant within 5 - 9 days and persisted even after one month. Overall, the quantitative CT parameters could well predict the severity of COVID-19. The lung volume percentage of -7 Hounsfield units (-7 HUs) had the largest crude odds ratio (OR: 1.999; 95% CI, 1.453 ~ 2.750; P < 0.001) and adjusted OR (adjusted OR: 1.768; 95% CI, 1.114 ~ 2.808; P = 0.016). The lung volume percentage of -6 HU showed the best predictive performance with the largest AUC of 0.808; the cutoff value of 5.93% showed 71.79% sensitivity and 84.62% specificity. Conclusion: Early quantitative chest CT parameters can be measured to assess the risk of progression to the critical stage of COVID-19; this is of critical importance in the clinical management of this disease.
Plantar Papules and Plaques: A Dermoscopic-Histopathological Correlation
Authors: Ankad Balachandra Suryakant , Koti Varsha R , Nikam Balkrishna P , Rangappa Manjula
Published: September 2021

Background: Painful lesions affecting the plantar aspect of the foot are routinely encountered in daily practice, and plantar wart, corn, and callus are the most common conditions. Although the clinical examination is sufficient to clinch an accurate diagnosis, atypical presentations indicate the need for invasive investigations like skin biopsy. Here we evaluated dermoscopic patterns of painful lesions affecting the plantar surface. Objectives: The current study aimed to, firstly, investigate the dermoscopic patterns and differentiate between painful papules and plaques on the foot, and, secondly, to analyze the histopathological correlation of these dermoscopic patterns. Methods: Following a cross-sectional design, the current study was carried out on patients with the clinical diagnosis of painful lesions of foot suggestive of plantar wart, corn, and callus referring to a tertiary care center from June 2019 to Jan 2020. Dermoscopy analysis and biopsy were performed for all participants. Results: Among 92 patients with painful plantar lesions, 56, 22, and 15 had a plantar wart, corn, and callus, respectively. Dermoscopy of warts revealed red dots (89.28%) and yellow halo (82.14%). A translucent central core (100%) and whitish ring (81.81%) on dermoscopy of patients with corn. Dermoscopy of callus demonstrated opaque yellow area in all (100%) the patients. Dermatoglyphics were absent in plantar wart in contrast to corn and callus, wherein they were preserved. Conclusions: Dermoscopy can be considered as a rapid, non-invasive, diagnostic tool in the daily practice of a dermatologist. Here, it assisted in distinguishing clinically akin painful plantar papules and plaques. These dermoscopic patterns also were well correlated histopathologically.
Predictors of Puberty Health Behaviors Based on Integrated Behavioral Model Among Girl’s High School Students in Birjand in 2020
Authors: Abbasi Kobra , Miri Mohammad Reza , Norozi Ensiyeh , Ramazani Abbas Ali
Published: September 2021

Background: From the beginning of puberty, girls are exposed to many physical-psychological problems that experience for the first time, so it is very important to pay attention to puberty health. Objectives: The aim of this study was to determine the predictors of puberty health behaviors based on application of the Integrated Behavioral Model (IBM) among girls’ high school students. Methods: This descriptive-analytical study was performed on 265 first grade girls’ high school students in Birjand in 2020 using multi-stags sampling. Data collection tools were a researcher-made questionnaire including demographic information and questions related to IBM constructs that were completed self-administered. Data were analyzed by SPSS 19 software using Pearson correlation coefficient and linear regression analysis. Results: Pearson correlation showed that all IBM constructs except experiential attitude and control belief had a significant correlation with puberty health behaviors (P < 0.04). In total, about 54% of the behavior variance was explained by three variables of intention, self-efficacy, and mother's job, among which intention was the strongest predictor of puberty health behaviors (P = 0.001). Conclusions: The results of the present study indicate the high predictive power of IBM for investigating puberty health behaviors. Therefore, using this model to design educational interventions and improve behaviors in the field of maturity is recommended.
A contribution to the genus Afronurus Lestage, 1924 in China (Ephemeroptera: Heptageniidae, Ecdyonurinae)
Authors: Zhang Wei , Lei Zhi-Ming , Li Wen-Juan , Zhou Chang-Fa
Published: September 2021

The genus Afronurus has several very common mayfly species in China and they are widely distributed in this country. Some of them are quite similar to each other in both imaginal and nymphal stages. However, these species have not been systematically compared and reviewed so far. In this study, six species are recognized. All nymphs of them share the following characters: gills V–VI with additional arrow-like accessory lobes, branched dentisetae, two rows of bristles and setae on hindtibiae and spotted abdominal terga. The males have divergent penes and clearly expressed titillators. The nymphs of the new species A. drepanophyllus sp. nov. have sickle-like gills I, spotted and striped body color, and males have unique genitalia. The nymphal stages of A. furcatus and A. hunanensis, which are associated and described for the first time, have similar body color to A. drepanophyllus sp. nov., but their pale dots on the head capsules and the shape of the hypopharynx are different. Keys to males and nymphs of the six species are provided.
CIC-NUTM1 Sarcomas Affecting the Spine
Authors: Yang Shaomin , Liu LiLi , Yan Yu , Jiang Liang , Han Songbo , Shen Danhua , Zhang Bo
Published: September 2021

Context.—

Tumors harboring CIC-NUTM1 fusion are a newly recognized rare sarcoma, but the documented cases are still limited. It is unclear whether it is the same as classic CIC-DUX4 sarcoma in terms of its clinical, pathologic, and behavioral aspects.

Objective.—

To further explore the clinicopathologic characteristics of CIC-NUTM1 sarcoma.

Design.—

The cases were diagnosed based on immunophenotype, next-generation sequencing, and fluorescence in situ hybridization tests and compared with the reported CIC-NUTM1 sarcomas in the literature.

Results.—

Three cases of CIC-NUTM1 sarcomas involving the spine in adults were described. The tumors occurred in 2 men and 1 woman, aged 38 to 61 years. Two tumors were located in thoracic vertebrae and 1 in a cervical vertebra. All were locally advanced lesions destroying the bone and soft tissues without spinal cord involvement or metastasis. The tumors were composed of monomorphic small to medium-sized cells with round to epithelioid appearance. The architecture was lobulated and solid with diffuse or multifocal myxoid stroma. Next-generation sequencing revealed an in-frame fusion between CIC (exon 16 or 17) and NUTM1 (exon 5 or 6) in 3 cases. Fluorescence in situ hybridization confirmed CIC and NUTM1 breaks, and immunohistochemistry showed NUT staining in the nucleus. The patients died of disease 8 to 15 months (mean, 10.7 months) after presentation. Of the CIC-NUTM1 sarcomas reported in the literature along with our cases (n = 11), 8 cases developed in axial bone (5 spine, 3 skull base).

Conclusions.—

CIC-NUTM1 sarcomas demonstrate distinct anatomic tropism for the axial skeleton and unfavorable behavior compared with classic CIC sarcoma.
O patriarcado como barreira no desenvolvimento do empreendedorismo feminino
Authors: Sueiro Simone Grecco Sanches
Published: September 2021

Este artigo teve como objetivo apresentar como o patriarcado tem sido discutido na literatura de administração. Para tanto, optou-se pela realização de uma revisão sistemática da literatura com técnicas de análise de conteúdo e classificação hierárquica descendente. No total foram estudados 79 artigos provenientes da base Web Of Science, no período de 1987 a 2020. Os resultados demonstram que os artigos foram agrupados de acordo com as seguintes categorias: a) as questões do feminismo e a injustiça dos direitos das mulheres; b) as questões  associadas à contextos em que evidenciam a desigualdade social e econômica, cultural e religiosa; c) as questões que abordam o conceito do feminismo e que as questões de desigualdade de gênero e d) as questões do equilíbrio da vida familiar, doméstica, religiosa e a vida profissional da mulher. Percebe-se o patriarcado como barreira no desenvolvimento da vida profissional das mulheres.
Cerimonial universitário: análise comparativa de cerimoniais nas universidades públicas do nordeste brasileiro
Authors: Silva Rafael Diego Jaires da , Cruz Nicholas Joseph Tavares da , Bittencourt Ibsen Mateus , Pinto Filho Jovino
Published: September 2021

As solenidades públicas têm na equipe de cerimonial uma maior segurança para garantia de formalidade, padronização e decoro, o que confere maior credibilidade da instituição à população e possibilita uma comunicação aproximativa com o público. Assim, o presente estudo, por meio de uma abordagem quali-quantitativa, se destina a analisar o papel do cerimonial institucional universitário, observando o caso da Universidade Federal de Alagoas – UFAL em comparação com dezessete Universidades Federais do Nordeste associadas à Associação Nacional dos Dirigentes das Instituições Federais de Ensino Superior – Andifes, levando-se em consideração a quantidade de pessoas que compõem a equipe de cerimonial e a quantidade de eventos que se encontram sob a responsabilidade dos cerimonialistas. Desse modo, identificamos como pontos de melhoria para o desempenho das atividades cerimoniais a existência de um manual de cerimonial institucional atualizado e a manutenção de uma estrutura organizada, visando colaborar na qualidade dos eventos oficiais e no atendimento às regras de conduta previstas na legislação para preservação da boa imagem da Instituição, tanto para o público interno quanto para o público externo. Por fim, como resultado, a pesquisa contribui com a valorização do cerimonial universitário, incentivo à construção de manuais para procedimentos em solenidades públicas e com a conservação de um desenho organizacional adequado às necessidades institucionais.
Estrutura institucional na avaliação e monitoramento de políticas públicas: uma análise nos países do MERCOSUL
Authors: Torres Carlos Alberto Ramos , Vieira Dalglish Fernando , Jacobovski Renata
Published: September 2021

O presente artigo procura analisar a institucionalidade do sistema avaliação e monitoramento de políticas públicas (AMPP) nos países do MERCOSUL (Argentina, Brasil, Paraguai e Uruguai). Especificamente, interessa descrever a estrutura institucional vigente para detectar a possível convergência, heterogeneidade e limitações dos distintos arranjos institucionais de AMPP nos países analisados. Trata-se de uma pesquisa qualitativa, que utiliza o procedimento de análise de conteúdo para estimar um indicador de institucionalização. O estudo utiliza como fonte de dados as principais legislações nacionais, normativas, planos e diretrizes de política pública vigentes, assim como dados secundários e relatórios de organizações internacionais. Considera-se que, um sistema nacional de avaliação e monitoramento consolidado e unificado, pode impactar positivamente na performance das políticas públicas. Os principais resultados da análise mostram que existe heterogeneidade na institucionalidade de AMPP dos países, e quando comparados, o sistema nacional do Brasil apresenta o maior nível (alto), seguido da Argentina e Uruguai (médio) e por último Paraguai (baixo). Por fim, os países coincidem na ausência de uma política nacional de avaliação e monitoramento ampla e unificada, assim como na falta de uma agência nacional/federal que coordene o sistema nacional de AMPP.
Inovação nas empresas de base tecnológica de pequeno porte: um estudo bibliométrico na base Scopus
Authors: Jesus Silvia Manoela Santos de , Oliveira Junior Antônio Martins de
Published: September 2021

Esse artigo tem como objetivo analisar as produções científicas sobre os indicadores de inovação que caracterizam as Empresas de Base Tecnológica de Pequeno Porte dentro do cenário atual de mercado mundial. Foram apresentadas discussões conceituais sobre empresas de base tecnológica e inovação, utilizando-se para justificar as análises encontradas neste estudo. Dentre os aspectos metodológicos, a pesquisa é exploratória e descritiva, com tratamento qualitativo e quantitativo. Para efeito da pesquisa, a busca das informações foi realizada através da Bibliometria, na base Scopus. Na busca, foram utilizadas as palavras-chave: 'indicadores+inovação+pequenas empresas' e, posteriormente, foi ampliada a pesquisa com as palavras-chave sinônimos e em inglês, para perceber as alterações em termos numéricos e de análises dentro dos critérios de validação de uma string. Os resultados obtidos foram que, apesar de haver discussões sobre conceitos de empresa de base tecnológica e inovação, ainda poucas pesquisas científicas que tratem deste tema. Os estudos resultantes desta pesquisa totalizaram em apenas, 20 artigos, o que motivou a desenvolver um aprofundamento em relação aos indicadores de inovação traçados para as empresas de base tecnológica de pequeno porte. No Brasil, apenas 1 (um) estudo foi realizado pela Universidade Estadual de Maringá em Parceria com a Universidade Positivo, no Paraná.
Analise econômica para implantação de um porto fluvial no município de Porto Nacional/TO
Authors: Abreu Ana Luiza Oliveira de
Published: September 2021

Os portos são considerados como uma das instalações mais importantes para a infraestrutura de transporte nacional, com isso o setor portuário contribui no processo de crescimento econômico e socioeconômico. Com a crescente produção e exportação de soja e milho no Tocantins, se faz necessário desenvolver e modernizar os meios de transporte para o escoamento dessas produções. Na presente pesquisa foi abordada a situação socioeconômica do município de Porto Nacional, com o objetivo de analisar a implantação de um porto fluvial, pois o mesmo tem um grande potencial de receber e escoar produto agrícola, mineral e combustível. Diante do exposto essa implantação seria um grande indutor de crescimento econômico para esta cidade.
Ética na engenharia civil
Authors: Zanon João Paulo Magalhães , Lage Eduardo Gouveia Santiago , Lima Diogo Pedreira
Published: September 2021

É essencial para o engenheiro ampliar uma visão sistemática do planeta, ou seja: saber que, como atuante de mudança social, ele é componente do todo. Neste aspecto, é efetivo dilatar capacidades científica e tecnológica com gestão moral. Ao assumir consciência da obrigação de harmonizar sua habilidade técnica com a habilidade humana, esse profissional aumentará a habilidade conceitual, a qual está diretamente integrada à constituição e conexão de todas as atividades, caráteres e interesses da organização a qual pertence ou presta serviço. Seja qual for à particularidade da engenharia, o seu profissional deve estar entrelaçado e empenhado com o presente e com o futuro da organização. É a partir dessa hipótese que está implantado o presente artigo, a qual objetiva expor uma reflexão sobre a força da Responsabilidade Social na formação do engenheiro. Procura-se no presente artigo ponderar os princípios que norteiam a Responsabilidade Social como uma plausível ajuda na gênese apropriada para os novos profissionais de engenharia.
Inspeção na ponte do setor Umuarama em Porto Nacional
Authors: Silva Lucas Neres da , Santos Douglas Freitas Augusto dos
Published: September 2021

As estruturas em concreto, principalmente as armadas, são o método construtivo mais utilizado no Brasil, indo desde simples moradias a monumentais obras civis como arranha-céus e grandes pontes espalhadas ao longo do país e do mundo. Em geral, estes tipos de estruturas são suscetíveis ao aparecimento de patologias ao longo de sua vida útil. Objetiva-se com este trabalho o estudo das patologias em concreto armado através de pesquisas na literatura e inspeção visual, tendente para a ponte de Porto Nacional Tocantins, situada no setor Umuarama. O objetivo deste estudo é identificar as manifestações patológicas presentes, mediante inspeção visual, registros fotográficos e literatura técnica. O mesmo visa o estudo e a apresentação das principais causas de patologias em concreto armado que obtém as seguintes problemáticas como erros construtivos, causas físicas e biológicas, inadequação ao ambiente, corrosão da armadura, fissuras e trincas, etc. As inspeções seguiram as diretrizes da NBR 9452 (2019) e o manual de inspeção de Pontes Rodoviárias (DNIT – 2004). Verificou-se que a ponte segundo o critério de classificação de condição de obras de artes especiais da NBR 9452 (2019) apresenta uma condição ruim, sendo atribuida a ela uma nota 2, o que torna necessário uma inspeção especial, mais detalhada.
Análises físico-químicas da qualidade da água de chuva armazenada em cisternas em cidades do interior de Pernambuco
Authors: Melo Grazielma Ferreira de , Silva Edimiley Nawanny Vieira da , Souza Hôrtencia Júlia de , Oliveira Mylena Renata de , Sampaio Lígia Rodrigues
Published: September 2021

A escassez de água é um problema característico de diversas regiões, uma solução viável e alternativa é o armazenamento de águas de chuvas em cisternas, que tornou-se popular em distintas regiões. Enfatizando o semiárido brasileiro, a pesquisa em questão tomou como área de estudo o Agreste e a Zona da Mata de Pernambuco, captando amostras de águas de chuvas armazenadas em cisterna e caracterizando-as através de 13 diferentes análises físico-químicas, correlacionando seus resultados com os aspectos geográficos, frequência de limpeza nas cisternas e outros possíveis fatores que resultam em alterações de suas características, associando às suas respectivas finalidades, fundamentando-se à resolução CONAMA N° 357 de março de 2005 e a portaria de consolidação N° 05 de setembro de 2017 anexo XX. Evidenciou-se que 67% das amostras coletadas são destinadas para fins não potáveis, embora apenas 33,33% realizam algum tipo de tratamento da água armazenada. Os resultados indicaram alta concentração de magnésio, dureza, alteração do pH e índice elevado de oxigênio dissolvido. A partir dos resultados, foi possível identificar que as águas de chuvas são indicadas para fins não potáveis, embora necessite de tratamento básico para adequar suas características.
IN VITRO COMPARISON OF THE ANTIMICROBIAL EFFECTS OF DIFFERENT ROOT CANAL MEDICAMENTS ON ENTEROCOCCUS FAECALIS AND CANDIDA ALBICANS
Authors: ARICAN Burçin , SAZAK ÖVEÇOĞLU Hesna
Published: September 2021

Objectives: To evaluate the antimicrobial effects of experimental root canal medicaments on Enterococcus faecalis and Candida albicans on day 3 and day 7 using quantitative polymerase chain reaction (Q-PCR) analyses.
Materials and Methods: 240 single-rooted, single-canalled human teeth were used. Root canals were shaped mechanically and embedded in acrylic blocks, then sterilized in an autoclave. The samples were divided into two groups and infected with E. faecalis and C. albicans, and then divided into subgroups (n=10); calcium hydroxide (Ca(OH)2), triple paste (TAP), double paste (DP), modified double paste (MDP), lactoferrin (Lf), negative and positive groups. At the end of 3 and 7 days, paper points containing the root canal samples were placed in empty Eppendorf tubes, and DNA was isolated. Real-time Q-PCR was applied and the data were analyzed statistically.
Results: The antimicrobial effects of each medicine increased from days 3 to 7. Ca(OH)2 and TAP groups showed the similar eradication rates for E. faecalis and C. albicans on day 3 and 7 (P > 0.05). There was no significant difference between DP, MDP and Lf for the eradication of microorganisms at both experimental days (P > 0.05), except the amount of eradicated E. faecalis by DP at day 7 in which DP caught the similar percentages with TAP and Ca(OH)2 (P < 0.05).
Conclusions: Experimental pastes demonstrated antimicrobial efficiancy similar to those used routinely in endodontic clinic. It is promising that lactoferrin which is a very biocompatible material can be used in different combinations as an intracanal medicament.
COMPARISON OF TWO AEROSOL-FREE CARIES REMOVAL METHODS - A SPLIT MOUTH RANDOMIZED CLINICAL TRIAL
Authors: DUMAN Canan , KALAOĞLU Elif , ŞİRİNOĞLU ÇAPAN Belen , EGİL Edibe
Published: September 2021

Objectives: The management of deep caries lesions in immature permanent molars might be challenging in clinical practice. Minimally invasive caries removal methods can maintain apexogenesis by preventing extensive tissue loss. Here we compare the chemo-mechanical caries removal (CMCR) gel and the polymer bur in terms of time spent on caries removal, patient acceptability, and clinical success.
Materials and Methods: The teeth of 30 children were randomly divided into two groups. The duration of each method, the level of cooperation during each method, and the child’s choice of caries removal method were recorded. Patients were followed at 6-month intervals for at least 2 years.
Results: The difference between the patients’ preferences was not statistically significant, while the average caries removal time of the polymer bur method was significantly shorter (p < 0.05). The rates of apical closure without pathology in CMCR and polymer bur groups were 63.2% and 73.7%, respectively, whereas 10% of each group underwent further treatments due to the clinical and/or radiographic pathology.
Conclusions: These methods were thought to serve as an interim treatment in managing immature permanent teeth with deep caries. Furthermore, these methods, which do not involve water cooling, can also minimize the risk of contamination and cross-infection.
CONTEMPORARY ENDODONTIC OBTURATION TECHNIQUES: A COMPREHENSIVE LITERATURE REVIEW
Authors: ZAN Recai , DEMİR Arzu Şeyma
Published: September 2021

The success of an endodontic treatment is excessively depends on obturation as well as irrigation. Hence, achiving a homogenious, impermeable and gap-free obturation plays a crucial role in endodontic treatment. Today, many materials and techniques have been developed for endodontic purpose such as those which applied with heat or vibration, those softened with non-toxic chemicals and those uses ultrasound energy. Some of these techniques are still preferred by proffessionals when some are abandoned. However, gutta-percha is the most used material either with or without sealer. Gutta-percha can be applied with cold or warm techniques. It’s known that warm gutta-percha technique leads a more homogenious obturation than cold techniques. Nevertheless, different obturation methods are convenient for different anatomic variations of root canal system. This review article summerize the contemporary and conventional obturation techniques with evaluation of their current status in endodontic implementation.
”Vokalhelvedet”: hvor svær er dansk udtale, og hvordan undervises der i udtale for andetsprogstalere?
Authors: Jespersen Anna , Hejná Míša
Published: September 2021

Det danske sprog anses af mange lørnere som svært at lære, og især anses det som svært at blive flydende i. Dette bliver ofte tilskrevet den svære danske udtale. Artiklen her viser, at sprogskolernes håndtering af udtaleundervisning kan bidrage til voksne andetsprogstaleres udtaleproblemer. Her undersøges voksne lørneres og underviseres iagttagelser omkring det svære danske sprog, og undervisningen af det. I denne undersøgelse inddrages en analyse af undervisningsmateriale brugt ved voksenundervisning i dansk som andetsprog, og en diskussion af danskeksamener for andetsprogstalere. Vores resultater indikerer at udtale, og især vokaler, anses af både lørnere og undervisere som særligt svære at mestre. Samtidig undervises der ifølge vores informanter ikke nok i vokaludtale på de danske sprogskoler. Selvom de to informantgrupper generelt er relativt enige er især mængden af undervisning i udtale et kontrastpunkt mellem lørnere og undervisere. Vi diskuterer denne forskel, samt betydningen af meget lidt undervisningsmateriale der fokuserer på udtale efter DU-modul 1, og et manglende fokus på udtale i danskeksamenerne.
Le voleur d’enfants (1906) : trompe-l’oeil médiatique et fausse nouvelle romanesque
Authors: Bouchard Pierre-Olivier
Published: September 2021

Le voleur d’enfants est un roman de Louis Forest paru dans en feuilleton dans Le matin en 1906. Le texte se démarque par sa forme inusitée, mimant la couverture d’une grande affaire criminelle par la presse. Fausse nouvelle, le roman ne vise pas tant à tromper qu’à divertir en jouant avec un certain imaginaire du crime et en utilisant les formes poétiques propres au journal de l’époque. À cet égard, le texte peut être analysé comme l’équivalent fictionnel d’un genre pictural visant à produire des effets similaires : le trompe-l’oeil.
« Conspuez l’espion ! C’est l’Allemand qu’il nous faut ! » : Fausses nouvelles et fabrique de l’espion dans l’Ouest de la France durant la Première Guerre mondiale
Authors: Richard Ronan
Published: September 2021

Durant la guerre, le cumul de tensions, d’angoisse et de traumas collectifs forme un « bouillon de culture » des plus favorables à l’émergence et à la prolifération des fausses nouvelles, des rumeurs et des légendes. La première d'entre elle, l'espionnite, explose dès les premières heures du conflit. L’arrière est alors le théâtre d’une véritable explosion chauvine conduisant nombre de civils à traquer sans relâche cet « ennemi de l’intérieur » diabolisé par la propagande sur la barbarie allemande. En Bretagne, cette psychose a été savamment préparée par des publications d'avant-guerre dénonçant la présence sur les côtes d'une « avant-garde de l’armée allemande ». Dans ce contexte, rumeurs et ragots fantasmatiques pullulent et créent une suspicion envers tout ce qui sort de l'ordinaire. Ces fausses nouvelles, parfois relayées par la presse, se répandent essentiellement par voie orale, par le biais des blessés, des permissionnaires ou encore des réfugiés. Elles transitent généralement par les principaux noeuds de communication, tout spécialement les gares. Ainsi abreuvées de rumeurs et de légendes, les populations de l’arrière s'impliquent activement dans cette traque de l'espion, dégénérant en violences populaires vengeresses et irrationnelles d'autant plus embarrassantes pour les autorités qu'en l'occurrence, ces espions sont partout imaginaires.
“Une grâce, une modestie, un sérieux”: The Reforming Neo-Classicism of Sedaine’s Philosophe sans le savoir
Authors: Gamble D.R.
Published: September 2021

The objective of this article is to explain how Michel-Jean Sedaine’s play Le Philosophe sans le savoir (1765), considered the most successful example of the drame bourgeois, is characterised not only by the theatrical innovations advocated by Diderot in his writing on drama, but by central aspects of the reforming aesthetic movement that dominated the last half of the eighteenth century, and which has come to be known as neo-classicism.
The Body of the Courtesan, the Body of the Novel: Characterizing La Dame aux camélias and A la recherche du temps perdu through Marguerite Gautier and Odette Swann
Authors: Bruhn Maury
Published: September 2021

As the work of critic Michael Finn has demonstrated, while Marcel Proust has a generally dismissive attitude towards the work of Alexandre Dumas fils, the latter’s character Marguerite Gauthier nonetheless inspired Proust’s portrayal of Odette Swann in A la recherche du temps perdu. This article builds on the work of Finn to establish narrative and character parallels between Proust’s novel and Dumas fils’ La Dame aux Camélias, and proposes that, given these clear resemblances, closely examining the ways in which Odette differs from Marguerite will help us understand the stylistic specificities of these novels. I ultimately argue that the portrayal of these courtesan figures echoes the formal properties of the novels themselves. Dumas fils’ novel and the character of Marguerite tend towards epistemological clarity and certainty, whereas Proust’s novel, and the character of Odette, reveal an open and heterogenous literary universe.
An integrated three-tier trust management framework in mobile edge computing using fuzzy logic
Authors: B.M. Mansour Merrihan , Abdelkader Tamer , Hashem Mohamed , El-Horbaty El-Sayed M.
Published: September 2021

Mobile edge computing (MEC) is introduced as part of edge computing paradigm, that exploit cloud computing resources, at a nearer premises to service users. Cloud service users often search for cloud service providers to meet their computational demands. Due to the lack of previous experience between cloud service providers and users, users hold several doubts related to their data security and privacy, job completion and processing performance efficiency of service providers. This paper presents an integrated three-tier trust management framework that evaluates cloud service providers in three main domains: Tier I, which evaluates service provider compliance to the agreed upon service level agreement; Tier II, which computes the processing performance of a service provider based on its number of successful processes; and Tier III, which measures the violations committed by a service provider, per computational interval, during its processing in the MEC network. The three-tier evaluation is performed during Phase I computation. In Phase II, a service provider total trust value and status are gained through the integration of the three tiers using the developed overall trust fuzzy inference system (FIS). The simulation results of Phase I show the service provider trust value in terms of service level agreement compliance, processing performance and measurement of violations independently. This disseminates service provider’s points of failure, which enables a service provider to enhance its future performance for the evaluated domains. The Phase II results show the overall trust value and status per service provider after integrating the three tiers using overall trust FIS. The proposed model is distinguished among other models by evaluating different parameters for a service provider.
A randomized trial to evaluate the impact of copra meal hydrolysate on gastrointestinal symptoms and gut microbiome
Authors: Sathitkowitchai Witida , Suratannon Narissara , Keawsompong Suttipun , Weerapakorn Wanlapa , Patumcharoenpol Preecha , Nitisinprasert Sunee , Nakphaichit Massalin
Published: September 2021

The impact of copra meal hydrolysate (CMH) on gut health was assessed by conducting a double-blinded, placebo-controlled study. Sixty healthy adult participants, aged 18–40 years were assigned to daily consume 3 g of CMH, 5 g of CMH or placebo in the form of drink powder for 21 days. Consumption of CMH at 3 g/d improved defecating conditions by reducing stool size and also relieved flatulence and bloating symptoms. Fecal samples were collected serially at the baseline before treatment, after the treatment and after a 2-week washout period. The gut microbiomes were similar among the treatment groups, with microbial community changes observed within the groups. Intake of CMH at 3 g/d led to increase microbial diversity and richness. Reduction of the ratio between Firmicutes to Bacteroidetes was observed, although it was not significantly different between the groups. The 3 g/d CMH treatment increased beneficial microbes in the group of fiber-degrading bacteria, especially human colonic Bacteroidetes, while induction of Bifidobacteriaceae was observed after the washout period. Intake of CMH led to increase lactic acid production, while 3 g/d supplement promoted the present of immunoglobulin A (IgA) in stool samples. The 3 g daily dose of CMH led to the potentially beneficial effects on gut health for healthy individuals.
The expansion and diversity of theCYP75gene family in Vitaceae
Authors: Xiao Yang , Wen Jun , Meng Ran , Meng Ying , Zhou Qiang , Nie Ze-Long
Published: September 2021

TheCYP75gene family plays an important role in flavonoid biosynthesis in plants. Little is known about the evolution of the gene family within the grape family. Here, we extracted theCYP75genes from transcriptome data of 15 grape species and 36 representative genomes from other plants to explore the evolutionary history of theCYP75gene family in Vitaceae. The structure of the CYP75 protein sequences is highly conserved with the variation mainly occurring in the N terminal and the middle region. The evolutionary analyses suggested classifying theCYP75gene family into three groups in Vitaceae, namely Vitaceae A1, Vitaceae A2 and Vitaceae B. The Vitaceae A1 and A2 belong to theCYP75Asubfamily and the Vitaceae B belongs to theCYP75Bsubfamily. Within the Vitaceae A1, most Vitaceae taxa present only one copy of the CYP75A protein sequence except forVitis viniferawith a high number of sequences, which might have originated through recent gene duplications after its split from the other species. Vitaceae A2 contain only CYP75A sequences from Vitaceae sister to one fromCamellia sinensis, probably representing a relict lineage. The CYP75B proteins were found to be dominated in Vitaceae and other angiosperms. Our results provide important insights into understanding the evolutionary history of theCYP75gene family in Vitaceae and other angiosperms.
Identification and characterization of expression profiles of neuropeptides and their GPCRs in the swimming crab, Portunus trituberculatus
Authors: Tu Shisheng , Xu Rui , Wang Mengen , Xie Xi , Bao Chenchang , Zhu Dongfa
Published: September 2021

Neuropeptides and their G protein-coupled receptors (GPCRs) regulate multiple physiological processes. Currently, little is known about the identity of native neuropeptides and their receptors in Portunus trituberculatus. This study employed RNA-sequencing and reverse transcription-polymerase chain reaction (RT-PCR) techniques to identify neuropeptides and their receptors that might be involved in regulation of reproductive processes of P. trituberculatus. In the central nervous system transcriptome data, 47 neuropeptide transcripts were identified. In further analyses, the tissue expression profile of 32 putative neuropeptide-encoding transcripts was estimated. Results showed that the 32 transcripts were expressed in the central nervous system and 23 of them were expressed in the ovary. A total of 47 GPCR-encoding transcripts belonging to two classes were identified, including 39 encoding GPCR-A family and eight encoding GPCR-B family. In addition, we assessed the tissue expression profile of 33 GPCRs (27 GPCR-As and six GPCR-Bs) transcripts. These GPCRs were found to be widely expressed in different tissues. Similar to the expression profiles of neuropeptides, 20 of these putative GPCR-encoding transcripts were also detected in the ovary. This is the first study to establish the identify of neuropeptides and their GPCRs in P. trituberculatus, and provide information for further investigations into the effect of neuropeptides on the physiology and behavior of decapod crustaceans.
https://ijsea.com/archive/volume10/issue9/IJSEA10091005.pdf
Authors: LI Huiling , SU Xuan , ZHANG Shuaipeng
Published: September 2021

Massive amounts of business process event logs are collected and stored by modern information systems. Model discovery aims to discover a process model from such event logs, however, most of the existing approaches still suffer from low efficiency when facing large-scale event logs. Event log sampling techniques provide an effective scheme to improve the efficiency of process discovery, but the existing techniques still cannot guarantee the quality of model mining. Therefore, a sampling approach based on set coverage algorithm named set coverage sampling approach is proposed. The proposed sampling approach has been implemented in the open-source process mining toolkit ProM. Furthermore, experiments using a real event log data set from conformance checking and time performance analysis show that the proposed event log sampling approach can greatly improve the efficiency of log sampling on the premise of ensuring the quality of model mining.
«ТЯНЬГУН» НАЧИНАЕТСЯ, "Земля и Вселенная"
Authors: Лисов И.А.
Published: September 2021

29 апреля 2021 г. с китайского космодрома Вэньчан на ракете CZ 5B на орбиту был выведен первый модуль Китайской космической станции. У Международной космической станции появился «младший брат», имеющий все шансы надолго пережить свою «старшую сестру».
НЕ ТОЛЬКО «СОСУЩЕСТВОВАНИЕ», НО И «ВЗАИМОПРОНИКНОВЕНИЕ»: ВОСПОМИНАНИЯ Е.А. КОСМИНСКОГО О НАУЧНЫХ КОМАНДИРОВКАХ В АНГЛИЮ 1952 И 1956 ГОДОВ, "Средние века"
Authors: Земляков М.В. , Селиванова О.В.
Published: September 2021

Статья продолжает предыдущую публикацию о воспоминаниях В.М. Лавровского, основанных на его впечатлениях от командировки в Великобританию в середине 1920-х годов. Во второй части вниманию читателей представлены документы, в которых Е.А. Косминский рассказывал о двух поездках в Соединенное королевство в 1952 и 1956 гг. Во вводном очерке авторы уделяют внимание отличию научной командировки 1925–1926 гг. от поездок 1950-х годов (в частности, совмещение научных занятий с административными обязанностями, значительный общественный резонанс и отклик в английской прессе). Каждый из публикуемых документов снабжен подробным комментарием, в котором указываются время и обстоятельства его появления, а также сделанные рукой Е.А. Косминского исправления и пояснения к машинописным текстам.
ОБЩИЕ СРЕДСТВА РЕМЕСЛЕННЫХ И ТОРГОВЫХ КОРПОРАЦИЙ РЕЙМСА XV–XVIII веков, "Средние века"
Authors: Кириллова Е.Н.
Published: September 2021

В работе рассмотрены традиции сбора, хранения, учета и расходования общих средств ремесленных и торговых корпораций Реймса в Средние века и Новое время. На эти средства корпорации платили королевские налоги, оплачивали труд своих должностных лиц, церковные службы, судебные издержки, вели текущие дела. Подробно рассмотрены источники поступлений: регулярные и разовые выплаты, включая вступительные взносы мастеров, подмастерьев и учеников, отчисления от штрафов и конфискаций и многие другие. Представлены основные статьи расходов, правила о регулярных финансовых отчетах представителям корпораций и городским властям и практики, направленные на предотвращение потерь и растрат общих средств.
Canadian Fathers’ Preferences for Support During the Transition to Fatherhood
Authors: Sevigny Phillip R. , Loutzenhiser Lynn , Oriet Chris
Published: September 2021

While there is growing recognition that fathers lack social support during the transition to fatherhood, little is known about the types of services fathers would access. An online survey was conducted with Canadian fathers asking about the type and helpfulness of support they sought. Participants also rated their interest in, convenience of, and the likelihood of using alternative options. All fathers sought support and the majority relied on partners, friends, and family. Fathers were equally likely to have accessed online support versus support from professionals. While fathers rated face-to-face interactions as potentially helpful, they rated online sources as most convenient.
Anti-Acetylcholinesterase Activity of Commercially Important Ceylon Black Tea (Camellia sinensis L.) Grades Belonging to Different Elevations: Potential Natural Product for Type 3 Diabetes Management?
Authors: Abeysekera Walimuni Kanchana Subhashini Mendis , Ratnasooriya Wanigasekara Daya , Abeysekera Walimuni Prabhashini Kaushalya Mendis , Premakumara Galbada Arachchige Sirimal
Published: September 2021

Aims: Sri Lankan tea which is known as the Ceylon tea is the world’s finest tea. Currently Sri Lanka remains as the second main black tea (BT) exporter and the main orthodox BT exporter in the world. Although several pharmacological activities of Ceylon tea have been reported, its anti-acetylcholinesterase (AChE) activity which has a direct relationship with the management of Alzheimer's disease or type 3 diabetes has not reported to date. Further, there are no comprehensive studies on anti-AChE activity of tea world over. Present study evaluated anti-AChE activity of commercially important Ceylon BT grades belonging to different elevations.

Methodology: Freeze dried hot water extracts of Broken Orange Pekoe Fannings (BOPF), Orange Pekoe (OP) and Dust No.1 BT grades from low, mid and high grown elevations and a Ceylon green tea sample collected from the local market were studied for anti-AChE activity using 96 well micro plate-based assay (n=3 each).

Results: Results showed that all tested Ceylon tea had anti-AChE activity with varying degrees of potentials in a dose dependent manner. The mean IC50 values of BOPF, OP and Dust No. 1 tea grades at different elevations varied from 499.61±10.95 - 569.19±5.78, 598.80±24.95 - 677.81±6.61 and 509.44±3.81 - 621.39±3.29 µg/mL respectively. Interestingly, observed anti-AChE activity of black tea showed significant differences (P< 0.05) among elevations. The order of potency of BOPF, OP and Dust No:1 BT for anti-AChE activity at different elevations was low grown>high grown=mid grown, high grown=low grown>mid grown and mid grown>low grown>high grown respectively. Anti-AChE activity of Ceylon green (433.96 ± 5.95 µg/mL) tea was significantly high (P<0.05) compared to the tested BT and activities of all Ceylon tea were moderate compared to the reference standard Galantamine (IC50:2.52±0.17 µg/mL).

Conclusion: It is concluded that selected Ceylon BT grades had varying levels of anti-AChE activity and it varied with the elevations.
Optimization of Hormone for Artificial Breeding and Seed Production of Clarias batrachus (Linnaeus, 1758) Under Captive Condition
Authors: Khan Abu Bakker Siddique , Akhter Mousumi , Bosu Aovijite , Ahmmed Shawon , Ali Md. Mohsin
Published: September 2021

Aims: The study aimed to develop brood stock of Magur (Clarias batrachus), artificial breeding and seed production under captive condition using growth hormones in north-eastern Bangladesh.

Study Design: Fifteen pairs of brood Clarias batrachus were used in this experiment. Brood fishes were reared up to maturation for spawning operation in the farm by providing artificial diet for 4-5 months before onset of breeding season. In the present experiment, the brood fishes were induced with three growth hormones viz., Ovupin (100 mg dompridone and 0.2 mg S-GnRHa) at the rate of 1 ml.kg-1 body weight, Flash (20 mg S-GnRHa, 10 mg dompridone IP and propylene glycol) at the rate of 1 ml.kg-1 body weight and Human Chorionic Gonadotropin (HCG) hormone at the rate of 2272 IU.kg-1 body weight; respectively. The broods were injected with single injection in all treatments.

Place and Duration of Study: The present study was conducted on induced spawning of Magur (Clarias batrachus) at the Reliance Aqua Farm, Boilor, Trisal of Mymensingh district from March to August, 2016.

Methodology: Sexually mature healthy, uninjured male and female fishes were collected from the broodstock ponds for induced breeding. The fishes were transferred in the clean and germ free conditioning tanks for about 6-7 hours. During conditioning, continuous splash of water was given by keeping the male and female separate. The fishes were then weighed individually and injected intramuscularly with Ovupin, Flash and HCG hormone respectively. Only females were injected at 45° angle of the caudal peduncle. About 23-24 hours of post-injection the testes from males were dissected and mixed with stripping eggs for fertilization.

Results: The incubation period for fertilized eggs were 23-24 hours for all the treatments. Fertilization rates were 78.20±0.52, 93.09±0.61 and 81.60±0.97 % and hatching rates were 54.93±0.61, 75.77±0.47 and 64.41±0.71 % in Ovupin, Flash and HCG treatments, respectively.

Conclusion: This study revealed higher fertilization (93.09 %) and hatching (75.77 %) rate was achieved with Flash hormone. Therefore, Flash hormone could be effective for the artificial breeding and seed production of Magur (Clarias batrachus).
Reduced TREM2 activation in microglia of patients with Alzheimer's disease
Authors: Okuzono Yuumi , Sakuma Hiroyuki , Miyakawa Shuuichi , Ifuku Masataka , Lee Jonghun , Das Debashree , Banerjee Antara , Zhao Yang , Yamamoto Koji , Ando Tatsuya , Sato Shuji
Published: September 2021

Loss‐of‐function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing Alzheimer's disease (AD). The mechanism through which TREM2 contributes to the disease (TREM2 activation vs inactivation) is largely unknown. Here, we analyzed changes in a gene set downstream of TREM2 to determine whether TREM2 signaling is modified by AD progression. We generated an anti‐human TREM2 agonistic antibody and defined TREM2 activation in terms of the downstream expression changes induced by this antibody in microglia developed from human induced pluripotent stem cells (iPSC). Differentially expressed genes (DEGs) following TREM2 activation were compared with the gene set extracted from microglial single nuclear RNA sequencing data of patients with AD, using gene set enrichment analysis. We isolated an anti‐TREM2‐specific agonistic antibody, Hyb87, from anti‐human TREM2 antibodies generated using binding and agonism assays, which helped us identify 300 upregulated and 251 downregulated DEGs. Pathway enrichment analysis suggested that TREM2 activation may be associated with Th2‐related pathways. TREM2 activation was lower in AD microglia than in microglia from healthy subjects or patients with mild cognitive impairment. TREM2 activation also showed a significant negative correlation with disease progression. Pathway enrichment analysis of DEGs controlled by TREM2 activity indicated that TREM2 activation in AD may lead to anti‐apoptotic signaling, immune response, and cytoskeletal changes in the microglia. We showed that TREM2 activation decreases with AD progression, in support of a protective role of TREM2 activation in AD. In addition, the agonistic anti‐TREM2 antibody can be used to identify TREM2 activation state in AD microglia.