bluuebunny/crossref_metadata_2025 huggingface dataset:
A General-Purpose Biotic Index to Measure Changes in Benthic Habitat Quality across Several Pressure Gradients
Authors: Labrune Céline , Gauthier Olivier , Conde Anxo , Grall Jacques , Blomqvist Mats , Bernard Guillaume , Gallon Régis , Dannheim Jennifer , Van Hoey Gert , Grémare Antoine
Published: June 2021

Realistic assessments of the ecological status of benthic habitats, as requested by European directives such as the Water Framework Directive and the European Marine Strategy Framework Directive, require biotic indices capable of detecting anthropogenic impact without having preliminary knowledge of the occurring pressures. In this context, a new general-purpose biotic index (GPBI) based on the deviation of benthic macrofauna community composition and structure from a valid reference (i.e., good ecological status) is proposed. GPBI is based on the assumption that as a site becomes impacted by a pressure, the most sensitive species are the first to disappear, and that stronger impacts lead to more important losses. Thus, it explicitly uses the within-species loss of individuals in the tested station in comparison to one or several reference stations as the basis of ecological status assessment. In this study, GPBI is successfully used in four case studies considering the impact of diversified pressures on benthic fauna: (1) maerl extraction in the northern Bay of Biscay, (2–3) dredging and trawling in the North Sea, and (4) hypoxic events at the seafloor in the Gullmarfjord. Our results show that GPBI was able to efficiently detect the impact of the different physical disturbances as well as that of hypoxia and that it performs better than commonly used pressure-specific indices (M-AMBI and TDI). Signal detection theory was used to propose a sound good/moderate ecological quality status boundary, and recommendations for future monitoring are also provided based on the reported performance of GPBI.
Capture Power Prediction of the Frustum of a Cone Shaped Floating Body Based on BP Neural Network
Authors: Wang Wei , Liu Yanjun , Bai Fagang , Xue Gang
Published: June 2021

How to improve the power generation of wave energy converters (WEC) has become one of the main research objectives in wave energy field. This paper illustrates a framework on the use of back propagation (BP) neural network in predicting capture power of the frustum of a cone shaped floating body. Mathematical model of single floating body is derived, and radius, semi-vertical angle, mass, submergence depth, power take-off (PTO) damping coefficient, and stiffness coefficient are identified as key variables. Commercial software ANSYS-AQWA is used for numerical simulations to obtain hydrodynamic parameters, and then capture power is calculated by these parameters. A database containing 100 samples is established by Latin hypercube sampling (LHS) method, and a simple feature study is conducted. A BP neural network model with high accuracy is designed and trained for predictions based on built database. The results show that forecasting results and desired outputs are in great agreement with error percentage not greater than 4%, correlation coefficient (CC) greater than 0.9, P value close to 1, and root mean square error (RMSE) less than 139 W. The proposed method provides a guideline for designers to identify basic parameters of the floating body and system damping coefficient.
A Proteomic Atlas of Lineage and Cancer-Polarized Expression Modules in Myeloid Cells Modeling Immunosuppressive Tumor-Infiltrating Subsets
Authors: Blanco Ester , Ibañez-Vea Maria , Hernandez Carlos , Drici Lylia , Martínez de Morentin Xabier , Gato Maria , Ausin Karina , Bocanegra Ana , Zuazo Miren , Chocarro Luisa , Arasanz Hugo , Fernandez-Hinojal Gonzalo , Fernandez-Irigoyen Joaquin , Smerdou Cristian , Garnica Maider , Echaide Miriam , Fernandez Leticia , Morente Pilar , Ramos-Castellanos Pablo , Llopiz Diana , Santamaria Enrique , Larsen Martin R. , Escors David , Kochan Grazyna
Published: June 2021

Monocytic and granulocytic myeloid-derived suppressor cells together with tumor-infiltrating macrophages constitute the main tumor-infiltrating immunosuppressive myeloid populations. Due to the phenotypic resemblance to conventional myeloid cells, their identification and purification from within the tumors is technically difficult and makes their study a challenge. We differentiated myeloid cells modeling the three main tumor-infiltrating types together with uncommitted macrophages, using ex vivo differentiation methods resembling the tumor microenvironment. The phenotype and proteome of these cells was compared to identify linage-dependent relationships and cancer-specific interactome expression modules. The relationships between monocytic MDSCs and TAMs, monocytic MDSCs and granulocytic MDSCs, and hierarchical relationships of expression networks and transcription factors due to lineage and cancer polarization were mapped. Highly purified immunosuppressive myeloid cell populations that model tumor-infiltrating counterparts were systematically analyzed by quantitative proteomics. Full functional interactome maps have been generated to characterize at high resolution the relationships between the three main myeloid tumor-infiltrating cell types. Our data highlights the biological processes related to each cell type, and uncover novel shared and differential molecular targets. Moreover, the high numbers and fidelity of ex vivo-generated subsets to their natural tumor-shaped counterparts enable their use for validation of new treatments in high-throughput experiments.
The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine
Authors: Rizzo Anthony E. , Gordon Jennifer C. , Berard Alicia R. , Burgener Adam D. , Avril Stefanie
Published: June 2021

The microbial colonization of the lower female reproductive tract has been extensively studied over the past few decades. In contrast, the upper female reproductive tract including the uterine cavity and peritoneum where the ovaries and fallopian tubes reside were traditionally assumed to be sterile under non-pathologic conditions. However, recent studies applying next-generation sequencing of the bacterial 16S ribosomal RNA gene have provided convincing evidence for the existence of an upper female reproductive tract microbiome. While the vaginal microbiome and its importance for reproductive health outcomes has been extensively studied, the microbiome of the upper female reproductive tract and its relevance for gynecologic cancers has been less studied and will be the focus of this article. This targeted review summarizes the pertinent literature on the female reproductive tract microbiome in gynecologic malignancies and its anticipated role in future research and clinical applications in personalized medicine.
Bundling of Ecosystem Services in Conservation Offsets: Risks and How They Can Be Avoided
Authors: Drechsler Martin
Published: June 2021

Conservation offsets are increasingly used as an instrument to conserve biodiversity and ecosystem services on private lands. Bundling ecosystem services (ES) in the market transactions saves costs but implies that only the bundle of ES is conserved while individual ES may decline. This paper presents a simple model analysis of a conservation offset scheme to identify conditions under which bundling can lead to such undesired declines. As it turns out, these are favoured by rarity of the ES as well as a positive correlation between their abundance and the cost of their conservation. A market rule is proposed that is able to avert undesired ES declines. Rather than on sums or means of ES, this market rule focuses on the least abundant ES. Systematic variation of model parameters shows that this trading rule is most effective in those cases where the likelihood of undesired ES losses is highest.
Testing a Gypsum Composite Based on Raw Gypsum with a Direct Admixture of Paraffin and Polymer to Improve Thermal Properties
Authors: Powała Krzysztof , Obraniak Andrzej , Heim Dariusz
Published: June 2021

The implemented new legal regulations regarding thermal comfort, the energy performance of residential buildings, and proecological requirements require the design of new building materials, the use of which will improve the thermal efficiency of newly built and renovated buildings. Therefore, many companies producing building materials strive to improve the properties of their products by reducing the weight of the materials, increasing their mechanical properties, and improving their insulating properties. Currently, there are solutions in phase-change materials (PCM) production technology, such as microencapsulation, but its application on a large scale is extremely costly. This paper presents a solution to the abovementioned problem through the creation and testing of a composite, i.e., a new mixture of gypsum, paraffin, and polymer, which can be used in the production of plasterboard. The presented solution uses a material (PCM) which improves the thermal properties of the composite by taking advantage of the phase-change phenomenon. The study analyzes the influence of polymer content in the total mass of a composite in relation to its thermal conductivity, volumetric heat capacity, and diffusivity. Based on the results contained in this article, the best solution appears to be a mixture with 0.1% polymer content. It is definitely visible in the tests which use drying, hardening time, and paraffin absorption. It differs slightly from the best result in the thermal conductivity test, while it is comparable in terms of volumetric heat capacity and differs slightly from the best result in the thermal diffusivity test.
Assessment of Operational Degradation of Pipeline Steels
Authors: Nykyforchyn Hryhoriy , Zvirko Olha , Dzioba Ihor , Krechkovska Halyna , Hredil Myroslava , Tsyrulnyk Oleksandr , Student Oleksandra , Lipiec Sebastian , Pala Robert
Published: June 2021

This paper summarizes a series of the authors’ research in the field of assessing the operational degradation of oil and gas transit pipeline steels. Both mechanical and electrochemical properties of steels are deteriorated after operation, as is their resistance to environmentally-assisted cracking. The characteristics of resistance to brittle fracture and stress corrosion cracking decrease most intensively, which is associated with a development of in-bulk dissipated microdamages of the material. The most sensitive indicators of changes in the material’s state caused by degradation are impact toughness and fracture toughness by the J-integral method. The degradation degree of pipeline steels can also be evaluated nondestructively based on in-service changes in their polarization resistance and potential of the fracture surface. Attention is drawn to hydrogenation of a pipe wall from inside as a result of the electrochemical interaction of pipe metal with condensed moisture, which facilitates operational degradation of steel due to the combined action of operating stresses and hydrogen. The development of microdamages along steel texture was evidenced metallographically as a trend to the selective etching of boundaries between adjacent bands of ferrite and pearlite and fractographically by revealing brittle fracture elements on the fracture surfaces, namely delamination and cleavage, indicating the sites of cohesion weakening between ferrite and pearlite bands. The state of the X52 steel in its initial state and after use for 30 years was assessed based on the numerical simulation method.
Surface Texturing of Polyethylene Terephthalate Induced by Excimer Laser in Silver Nanoparticle Colloids
Authors: Siegel Jakub , Savenkova Tatiana , Pryjmaková Jana , Slepička Petr , Šlouf Miroslav , Švorčík Václav
Published: June 2021

We report on a novel technique of surface texturing of polyethylene terephthalate (PET) foil in the presence of silver nanoparticles (AgNPs). This approach provides a variable surface morphology of PET evenly decorated with AgNPs. Surface texturing occurred in silver nanoparticle colloids of different concentrations under the action of pulse excimer laser. Surface morphology of PET immobilized with AgNPs was observed by AFM and FEGSEM. Atomic concentration of silver was determined by XPS. A presented concentration-controlled procedure of surface texturing of PET in the presence of silver colloids leads to a highly nanoparticle-enriched polymer surface with a variable morphology and uniform nanoparticle distribution.
Laser Patterning of Aligned Carbon Nanotubes Arrays: Morphology, Surface Structure, and Interaction with Terahertz Radiation
Authors: Sedelnikova Olga V. , Gorodetskiy Dmitriy V. , Kurenya Alexander G. , Baskakova Kseniya I. , Shlyakhova Elena V. , Makarova Anna A. , Gorokhov Gleb V. , Bychanok Dzmitry S. , Kuzhir Polina P. , Maksimenko Sergey A. , Bulusheva Lyubov G. , Okotrub Alexander V.
Published: June 2021

The patterning of arrays of aligned multi-walled carbon nanotubes (MWCNTs) allows creating metastructures for terahertz (THz) applications. Here, the strips and columns from MWCNTs vertically grown on silicon substrates are prepared using CO2 laser treatment. The tops of the patterned arrays are flat when the laser power is between 15 and 22 W, and craters appear there with increasing power. Laser treatment does not destroy the alignment of MWCNTs while removing their poorly ordered external layers. The products of oxidative destruction of these layers deposit on the surfaces of newly produced arrays. The oxygen groups resulting from the CO2 laser treatment improve the wettability of nanotube arrays with an epoxy resin. We show that the patterned MWCNT arrays absorb the THz radiation more strongly than the as-synthesized arrays. Moreover, the pattern influences the frequency behavior of the absorbance.
Assessment of the Suitability of Ceramic Waste in Geopolymer Composites: An Appraisal
Authors: Luhar Ismail , Luhar Salmabanu , Abdullah Mohd Mustafa Al Bakri , Nabiałek Marcin , Sandu Andrei Victor , Szmidla Janusz , Jurczyńska Anna , Razak Rafiza Abdul , Aziz Ikmal Hakem A , Jamil Noorina Hidayu , Deraman Laila Mardiah
Published: June 2021

Currently, novel inorganic alumino-silicate materials, known as geopolymer composites, have emerged swiftly as an ecobenevolent alternative to contemporary ordinary Portland cement (OPC) building materials since they display superior physical and chemical attributes with a diverse range of possible potential applications. The said innovative geopolymer technology necessitates less energy and low carbon footprints as compared to OPC-based materials because of the incorporation of wastes and/or industrial byproducts as binders replacing OPC. The key constituents of ceramic are silica and alumina and, hence, have the potential to be employed as an aggregate to manufacture ceramic geopolymer concrete. The present manuscript presents a review of the performance of geopolymer composites incorporated with ceramic waste, concerning workability, strength, durability, and elevated resistance evaluation.
Biological Effects of Bioresorbable Materials in Alveolar Ridge Augmentation: Comparison of Early and Slow Resorbing Osteosynthesis Materials
Authors: Kawai Hotaka , Sukegawa Shintaro , Nakano Keisuke , Takabatake Kiyofumi , Ono Sawako , Nagatsuka Hitoshi , Furuki Yoshihiko
Published: June 2021

The purpose of this study was to investigate the bone healing properties and histological environment of a u-HA/PLLA/PGA (u-HA—uncalcined and unsintered hydroxyapatite, PLLA—Poly L-lactic acid, PGA—polyglycolic acid) composite device in humans, and to understand the histological dynamics of using this device for maxillofacial treatments. Twenty-one subjects underwent pre-implant maxillary alveolar ridge augmentation with mandibular cortical bone blocks using u-HA/PLLA or u-HA/PLLA/PGA screws for fixation. Six months later, specimens of these screws and their adjacent tissue were retrieved. A histological and immunohistochemical evaluation of these samples was performed using collagen 1a, ALP (alkaline phosphatase), and osteocalcin. We observed that alveolar bone augmentation was successful for all of the subjects. Upon histological evaluation, the u-HA/PLLA screws had merged with the bone components, and the bone was directly connected to the biomaterial. In contrast, direct bone connection was not observed for the u-HA/PLLA/PGA screw. Immunohistological findings showed that in the u-HA/PLLA group, collagen 1a was positive for fibers that penetrated vertically into the bone. Alkaline phosphatase was positive only in the u-HA/PLLA stroma, and the stroma was negative for osteocalcin. In this study, u-HA/PLLA showed a greater bioactive bone conductivity than u-HA/PLLA/PGA and a higher biocompatibility for direct bone attachment. Furthermore, u-HA/PLLA was shown to have the potential for bone formation in the stroma.
Fully Quantum Modeling of Exciton Diffusion in Mesoscale Light Harvesting Systems
Authors: Zheng Fulu , Chen Lipeng , Gao Jianbo , Zhao Yang
Published: June 2021

It has long been a challenge to accurately and efficiently simulate exciton–phonon dynamics in mesoscale photosynthetic systems with a fully quantum mechanical treatment due to extensive computational resources required. In this work, we tackle this seemingly intractable problem by combining the Dirac–Frenkel time-dependent variational method with Davydov trial states and implementing the algorithm in graphic processing units. The phonons are treated on the same footing as the exciton. Tested with toy models, which are nanoarrays of the B850 pigments from the light harvesting 2 complexes of purple bacteria, the methodology is adopted to describe exciton diffusion in huge systems containing more than 1600 molecules. The superradiance enhancement factor extracted from the simulations indicates an exciton delocalization over two to three pigments, in agreement with measurements of fluorescence quantum yield and lifetime in B850 systems. With fractal analysis of the exciton dynamics, it is found that exciton transfer in B850 nanoarrays exhibits a superdiffusion component for about 500 fs. Treating the B850 ring as an aggregate and modeling the inter-ring exciton transfer as incoherent hopping, we also apply the method of classical master equations to estimate exciton diffusion properties in one-dimensional (1D) and two-dimensional (2D) B850 nanoarrays using derived analytical expressions of time-dependent excitation probabilities. For both coherent and incoherent propagation, faster energy transfer is uncovered in 2D nanoarrays than 1D chains, owing to availability of more numerous propagating channels in the 2D arrangement.
Sustainable Green Lightweight Concrete Containing Plastic-Based Green Lightweight Aggregate
Authors: Alqahtani Fahad K.
Published: June 2021

Nowadays the environment and its natural resources face many issues, related to the depletion of natural resources beside the increase in environmental pollution resulted from uncontrolled plastic waste disposal. Therefore, it is important to find effective and feasible solutions to utilize these wastes, such as using them to produce environmentally friendly green concrete. In this study, plastic-based green lightweight aggregates (PGLAs) containing PET plastic waste and by product additives were developed, and their subsequent physical and mechanical properties were compared with those of reference aggregates. Then, green lightweight aggregate concrete mixes (GLACs) were produced at 100% replacement of normal weight and lightweight coarse aggregate with developed PGLAs; and their fresh, hardened, microscopic and durability-related properties were compared to those of control mixes. Study results revealed that the unit weight of PGLAs were 21% to 29% less than that of normal coarse aggregate. Additionally, PGLAs had low water absorption that varied between 1.2% and 1.6%. The developed aggregates had 45% higher strength compared to that of lightweight coarse aggregate. Study results confirmed that structural green lightweight aggregate concretes (GLACs), that satisfied the dry density, compressive and splitting tensile strength requirements specified in ASTM C330, were feasibly produced. Finally, GLACs had low-to-moderate chloride penetration in accordance with ASTM C1202, thus it can be used in those areas exposed to the risk of chloride attack.
Intergranular Corrosion and Microstructural Evolution in a Newly Designed Al-6Mg Alloy
Authors: Choi Kweon-Hoon , Kim Bong-Hwan , Lee Da-Bin , Yang Seung-Yoon , Kim Nam-Seok , Ha Seong-Ho , Yoon Young-Ok , Lim Hyun-Kyu , Kim Shae-Kwang
Published: June 2021

In this work, the microstructure and corrosion behavior of a novel Al-6Mg alloy were investigated. The alloy was prepared by casting from pure Al and Mg+Al2Ca master alloy. The ingots were homogenized at 420 °C for 8 h, hot-extruded and cold-rolled with 20% reduction (CR20 alloy) and 50% reduction (CR50 alloy). The CR50 alloy exhibited a higher value of intergranular misorientation due to a higher cold rolling reduction ratio. The average grain sizes were 19 ± 7 μm and 17 ± 9 μm for the CR20 and CR50 alloys, respectively. An intergranular corrosion (IGC) behavior was investigated after sensitization by a nitric acid mass-loss test (ASTM G67). The mass losses of both the CR20 and CR50 alloys were similar at early periods of sensitization, however, the CR20 alloy became more susceptible to IGC as the sensitization time increased. Grain size and β phase precipitation were two critical factors influencing the IGC behavior of this alloy system.
Effect of Co/Ni Substituting Fe on Magnetocaloric Properties of Fe-Based Bulk Metallic Glasses
Authors: Guo Jia , Xie Lei , Liu Cong , Li Qiang , Huo Juntao , Chang Chuntao , Li Hongxiang , Ma Xu
Published: June 2021

In this work, Fe80-xMxP13C7 (M = Co, Ni; x = 0, 5 and 10 at.%) bulk metallic glasses (BMGs) were prepared, and the effect of the Co/Ni elements substitution for Fe on the magnetocaloric properties of Fe80P13C7 BMG has been investigated systematically. The Curie temperature (TC) of the present Fe-based BMGs increases with the substitution of Fe by Co/Ni. The magnetic entropy change (ΔSM) of the present Fe-based BMGs increases first and then decreases with the increase of Fe substituted by Co, but monotonically decreases with the increase of Fe substituted by Ni. Among the present Fe-based BMGs, the Fe75Co5P13C7 BMG exhibits the maximum ΔSM value of 5.21 J kg−1 K−1 at an applied field of 5 T, which is the largest value among Fe-based amorphous alloys without any rare earth elements reported so far. The present Fe-based BMGs exhibit the large glass forming ability, tunable TC and enhanced ΔSM value, which are beneficial for magnetic refrigerant materials.
Empowering the Emission of Upconversion Nanoparticles for Precise Subcellular Imaging
Authors: Rostami Iman
Published: June 2021

Upconversion nanoparticles (UCNPs) are a class of inorganic fluorophores that follow the anti-Stokes mechanism, to which the wavelength of emission is shorter than absorption. This unique optical behavior generates relatively long-lived intermediate energy levels of lanthanides that stabilize the excitation state in the fluorescence process. Longer-wavelength light sources, e.g., near-infrared (NIR), penetrate deeper into biological materials such as tissue and cells that provide a larger working space for cell biology applications and imaging, whereby UCNPs have recently gained increasing interest in medicine. In this report, the emission intensity of a gadolinium-based UCNP was screened by changing the concentrations of the constituents. The optimized condition was utilized as a luminescent nanoprobe for targeting the mitochondria as a distinguished subcellular organelle within differentiated neuroblastoma cells. The main goal of this study is to illustrate the targeting process within the cells in a native state using modified UCNPs. Confocal microscopy on the cells treated with the functionalized UCNPs indicated a selective accumulation of UCNPs after immunolabeling. To tackle the insolubility of as-synthesized particles in water-based media, the optimized UCNPs were surface-coated with polyamidoamine (PAMAM) dendrimers that due to peripheral amino groups are suitable for functionalizing with peptides and antibodies. Ultimately, we concluded that UCNPs are potentially versatile and ideal tools for NIR bioimaging and capable of making adequate contrast against biomaterials to be detectable in electron microscopy (EM) imaging.
All-Solid-State Optical Phased Arrays of Mid-Infrared Based Graphene-Metal Hybrid Metasurfaces
Authors: Wang Yue , Wang Yu , Yang Guohui , Li Qingyan , Zhang Yu , Yan Shiyu , Wang Chunhui
Published: June 2021

Optical phased arrays (OPAs) are essential optical elements in applications that require the ability to manipulate the light-wavefront, such as beam focusing and light steering. To miniaturize the optical components, active metasurfaces, especially graphene metasurfaces, are used as competent alternatives. However, the metasurface cannot achieve strong resonance effect and phase control function in the mid-infrared region only relying on a single-layer graphene. Here we present a graphene-metal hybrid metasurface that can generate a specific phase or a continuous sweep in the range of a 275°-based single-layer graphene structure. A key feature of our design is that the phase adjustment mainly depends on the combination mechanism of resonance intensity and frequency modulation. An all-solid-state, electrically tunable, and reflective OPA is designed by applying the bias voltage to a different pixel metasurface. The simulation results show that the maximum deflection angle of the OPA can reach 42.716°, and the angular resolution can reach 0.62°. This design can be widely applied to mid-infrared imaging, optical sensing, and optical communication systems.
Cardio-Cerebral Infarction, Free-Floating Thrombosis and Hyperperfusion in COVID-19
Authors: Koneru Sitara , Jillella Dinesh V. , Nogueira Raul G.
Published: June 2021

Cardio-cerebral infarction, which refers to an acute ischemic stroke (AIS) and acute myocardial infarction (AMI) that occur concurrently, is an uncommon phenomenon with a grave prognosis. Intraluminal carotid thrombus (ICT) is an infrequently encountered cause of ischemic stroke and can be associated with an underlying hypercoagulable state. One severe yet prevalent complication of infection with Coronavirus Disease 2019 (COVID-19) is thrombosis from multi-pathway inflammatory responses. Here, we present a unique case of cardio-cerebral infarction, with a free-floating intraluminal thrombus in the left internal carotid artery, in the setting of recent COVID-19 infection, and with the etiology of both events attributed to a COVID-19 hypercoagulable state. CT perfusion imaging also showed an interesting imaging finding of hyperperfusion, which is believed to be a form of dysfunctional cerebral autoregulation.
Effect of Microalgae and Macroalgae Extracts on Non-Alcoholic Fatty Liver Disease
Authors: González-Arceo Maitane , Gómez-Zorita Saioa , Aguirre Leixuri , Portillo María P.
Published: June 2021

The present review aims to gather scientific evidence regarding the beneficial effects of microalgae and macroalgae extracts on non-alcoholic fatty liver disease (NAFLD). The described data show that both microalgae and macroalgae improved this alteration. The majority of the reported studies analysed the preventive effects because algae were administered to animals concurrent with the diet that induced NAFLD. The positive effects were demonstrated using a wide range of doses, from 7.5 to 300 mg/kg body weight/day or from 1 to 10% in the diet, and experimental periods ranged from 3 to 16 weeks. Two important limitations on the scientific knowledge available to date are that very few studies have researched the mechanisms of action underlying the preventive effects of microalgae on NAFLD and that, for the majority of the algae studied, a single paper has been reported. For these reasons, it is not possible to establish the best conditions in order to know the beneficial effects that these algae could bring. In this scenario, further studies are needed. Moreover, the beneficial effects of algae observed in rodent need to be confirmed in humans before we can start considering these products as new tools in the fight against fatty liver disease.
The Impact of COVID-19 Lockdown on Patients with Obesity after Intensive Cognitive Behavioral Therapy—A Case-Control Study
Authors: Calugi Simona , Andreoli Beatrice , Dametti Laura , Dalle Grave Anna , Morandini Nicole , Dalle Grave Riccardo
Published: June 2021

Background: The COVID-19 lockdown may have negatively impacted the treatment of obesity. This study aimed to assess the effect of COVID-19 lockdown in patients with obesity treated with intensive residential cognitive behavioral therapy (CBT-OB). Methods: This retrospective case-control study analyzed 129 patients with severe obesity who experienced COVID-19 lockdown in the 6 months after discharge from intensive residential CBT-OB, comparing their outcomes on weight loss, binge-eating episodes, and general health status with those in a sample of patients matched by gender, age, and body mass index given the same treatment before the COVID-19 outbreak as control. Patients were assessed at baseline and by phone interview 6-month follow-up. Results: Both groups had lost more than 9% of their baseline bodyweight and reported a significant decrease in binge-eating episodes and similar general health status at 6-month follow-up. However, control patients achieved a significantly greater weight loss than those who experienced lockdown, although half of lockdown patients reported persisting with CBT-OB procedures after their discharge. Conclusion: Patients with obesity treated with CBT-OB and exposed to COVID-19 lockdown, despite achieving lower weight loss than non-exposed patients, had a healthy weight loss at 6-month follow-up and comparable reduction in binge-eating behaviors.
Higher Dietary Inflammation in Patients with Schizophrenia: A Case-Control Study in Korea
Authors: Cha Hee Yun , Yang Soo Jin , Kim Sung-Wan
Published: June 2021

Inflammation is a risk factor for the onset and progression of schizophrenia, and dietary factors are related to chronic inflammation. We investigated whether the dietary inflammatory index (DII) is associated with schizophrenia in the Korean population. Of the 256 subjects who responded to the questionnaire, 184 subjects (117 controls; 67 individuals with schizophrenia) were included in this case-control study. A semi-quantitative food frequency questionnaire was used to evaluate the dietary intakes of the study participants. The energy-adjusted DII (E-DII) was used to assess the inflammatory potential of the participants’ diets. Dietary intakes of vitamin C, niacin, and folate were significantly reduced in the patients with schizophrenia. The patients with schizophrenia had higher E-DII scores than the controls (p = 0.011). E-DII was positively associated with schizophrenia (odds ratio = 1.254, p = 0.010). The additional analysis confirmed that E-DII was significantly associated with schizophrenia, especially in the third tertile group of E-DII scores (odds ratio = 2.731, p = 0.016). Our findings suggest that patients with schizophrenia have more pro-inflammatory diets.
Application of Magnetic Resonance Imaging in the Evaluation of Nutritional Status: A Literature Review with Focus on Dialysis Patients
Authors: Inoue Tsutomu , Kozawa Eito , Ishikawa Masahiro , Okada Hirokazu
Published: June 2021

Magnetic resonance imaging (MRI) is indispensable in clinical medicine for the morphological and tomographic evaluation of many parenchymal organs. With varied imaging methods, diverse biological information, such as the perfusion volume and measurements of metabolic products, can be obtained. In addition to conventional MRI for morphological assessment, diffusion-weighted MRI/diffusion tensor imaging is used to evaluate white matter structures in the brain; arterial spin labeling is used for cerebral blood flow evaluation; magnetic resonance elastography for fatty liver and cirrhosis evaluation; magnetic resonance spectroscopy for evaluation of metabolites in specific regions of the brain; and blood oxygenation level-dependent imaging for neurological exploration of eating behavior, obesity, and food perception. This range of applications will continue to expand in the future. Nutritional science is a multidisciplinary and all-inclusive field of research; therefore, there are many different applications of MRI. We present a literature review of MRI techniques that can be used to evaluate the nutritional status, particularly in patients on dialysis. We used MEDLINE as the information source, conducted a keyword search in PubMed, and found that, as a nutritional evaluation method, MRI has been used frequently to comprehensively and quantitatively evaluate muscle mass for the determination of body composition.
Chrysin: Perspectives on Contemporary Status and Future Possibilities as Pro-Health Agent
Authors: Stompor-Gorący Monika , Bajek-Bil Agata , Machaczka Maciej
Published: June 2021

Chrysin belongs to the group of natural polyphenols. It can be found, among others, in honey, propolis and fruits and has a wide range of biological activities, including the prevention of oxidative stress, inflammation, neurodegeneration and carcinogenesis. Being a part of the human diet, chrysin is considered to be a promising compound to be used in the prevention of many diseases, including cancers, diabetes and neurodegenerative diseases such as Alzheimer’s or Parkinson’s. Nevertheless, due to the low solubility of chrysin in water and under physiological conditions, its bioavailability is low. For this reason, attempts at its functionalization have been undertaken, aiming to increase its absorption and thus augment its in vivo therapeutic efficacy. The aim of this review is to summarize the most recent research on chrysin, including its sources, metabolism, pro-health effects and the effects of its functionalization on biological activity and pharmacological efficacy, evaluated both in vitro and in vivo.
Tamoxifen Suppresses the Immune Response to Plasmodium berghei ANKA and Exacerbates Symptomatology
Authors: Cervantes-Candelas Luis , Aguilar-Castro Jesús , Buendía-González Fidel , Fernández-Rivera Omar , Cervantes-Sandoval Armando , Morales-Montor Jorge , Legorreta-Herrera Martha
Published: June 2021

Malaria is the most lethal parasitic disease in the world. Mortality and severity in symptoms are higher in men than women, suggesting that oestrogens, which are in higher concentration in females than in males, may regulate the immune response against malaria. Tamoxifen, a selective oestrogen receptor modulator used in breast cancer treatment due to its antagonistic effect on oestrogen receptors α and β, is also studied because of its potential therapeutic use for several parasitic diseases. However, most studies, including one in malaria, have not addressed the immunomodulatory role of tamoxifen. In this work, we evaluated the effect of tamoxifen on the immune response of CBA/Ca mice against Plasmodium berghei ANKA. This study showed for the first time that tamoxifen increased parasite load, aggravated symptoms by decreasing body temperature and body weight, and worsened anaemia. Additionally, tamoxifen significantly increased the splenic index and the percentages of CD4+ and NK+ cells on day eight post-infection. By contrast, tamoxifen decreased both CD8+ and B220+ populations in the spleen and decreased the serum levels of IL-2, IL-6, and IL-17. Our findings support the notion that tamoxifen is a potent immunomodulator in malaria-infected mice and suggest caution when administering it to malaria-infected women with breast cancer.
Guest-Mediated Reversal of the Tumbling Process in Phosphorus-Dendritic Compounds Containing β-Cyclodextrin Units: An NMR Study
Authors: Sorroza-Martínez Kendra , González-Méndez Israel , Vonlanthen Mireille , Cuétara-Guadarrama Fabián , Illescas Javier , Zhu Xiao Xia , Rivera Ernesto
Published: June 2021

The conformational study of dendritic platforms containing multiple β-cyclodextrin (βCD) units in the periphery is relevant to determine the availability of βCD cavities for the formation of inclusion complexes in aqueous biological systems. In this work, we performed a detailed conformational analysis in D2O, via 1D and 2D NMR spectroscopy of a novel class of phosphorus dendritic compounds of the type P3N3-[O-C6H4-O-(CH2)n-βCD]6 (where n = 3 or 4). We unambiguously demonstrated that a functionalized glucopyranose unit of at least one βCD unit undergoes a 360° tumbling process, resulting in a deep inclusion of the spacer that binds the cyclodextrin to the phosphorus core inside the cavity, consequently limiting the availability of the inner cavities. In addition, we confirmed through NMR titrations that this tumbling phenomenon can be reversed for all βCD host units using a high-affinity guest, namely 1-adamantanecarboxylic acid (AdCOOH). Our findings have demonstrated that it is possible to create a wide variety of multi-functional dendritic platforms.
Anti-Tumoral Effects of a (1H-Pyrrol-1-yl)Methyl-1H-Benzoimidazole Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines
Authors: Nicolai Alice , Madia Valentina Noemi , Messore Antonella , De Vita Daniela , De Leo Alessandro , Ialongo Davide , Tudino Valeria , Tortorella Elisabetta , Scipione Luigi , Taurone Samanta , Pergolizzi Tiziano , Artico Marco , Di Santo Roberto , Costi Roberta , Scarpa Susanna
Published: June 2021

Nocodazole is an antineoplastic agent that exerts its effects by depolymerizing microtubules. Herein we report a structural analog of nocodazole, a (1H-pyrrol-1-yl)methyl-1H-benzoimidazole carbamate ester derivative, named RDS 60. We evaluated the antineoplastic properties of RDS 60 in two human head and neck squamous cell carcinoma (HNSCC) cell lines and we found that this compound significantly inhibited replication of both HNSCC cell lines without inducing any important cytotoxic effect on human dermal fibroblasts and human keratinocytes. The treatment of HNSCC cell lines with 1 μM RDS 60 for 24 h stopped development of normal bipolar mitotic spindles and, at the same time, blocked the cell cycle in G2/M phase together with cytoplasmic accumulation of cyclin B1. Consequently, treatment with 2 μM RDS 60 for 24 h induced the activation of apoptosis in both HNSCC cell lines. Additionally, RDS 60 was able to reverse the epithelial-mesenchymal transition and to inhibit cell migration and extracellular matrix infiltration of both HNSCC cell lines. The reported results demonstrate that this compound has a potent effect in blocking cell cycle, inducing apoptosis and inhibiting cell motility and stromal invasion of HNSCC cell lines. Therefore, the ability of RDS 60 to attenuate the malignancy of tumor cells suggests its potential role as an interesting and powerful tool for new approaches in treating HNSCC.
Subcutaneously Injectable Hyaluronic Acid Hydrogel for Sustained Release of Donepezil with Reduced Initial Burst Release: Effect of Hybridization of Microstructured Lipid Carriers and Albumin
Authors: Kang Nae-Won , Yoon So-Yeon , Kim Sungho , Yu Na-Young , Park Ju-Hwan , Lee Jae-Young , Cho Hyun-Jong , Kim Dae-Duk
Published: June 2021

The daily oral administration of acetylcholinesterase (AChE) inhibitors for Alzheimer’s disease features low patient compliance and can lead to low efficacy or high toxicity owing to irregular intake. Herein, we developed a subcutaneously injectable hyaluronic acid hydrogel (MLC/HSA hydrogel) hybridized with microstructured lipid carriers (MLCs) and human serum albumin (HSA) for the sustained release of donepezil (DNP) with reduced initial burst release. The lipid carrier was designed to have a microsized mean diameter (32.6 ± 12.8 µm) to be well-localized in the hydrogel. The hybridization of MLCs and HSA enhanced the structural integrity of the HA hydrogel, as demonstrated by the measurements of storage modulus (G′), loss modulus (G″), and viscosity. In the pharmacokinetic study, subcutaneous administration of MLC/HSA hydrogel in rats prolonged the release of DNP for up to seven days and reduced the initial plasma concentration, where the Cmax value was 0.3-fold lower than that of the control hydrogel without a significant change in the AUClast value. Histological analyses of the hydrogels supported their biocompatibility for subcutaneous injection. These results suggest that a new hybrid MLC/HSA hydrogel could be promising as a subcutaneously injectable controlled drug delivery system for the treatment of Alzheimer’s disease.
Religious, but Not Spiritual: A Constructive Proposal
Authors: Simmons J. Aaron
Published: June 2021

Often the debates in philosophy of religion are quite disconnected from the empirical data gathered in the sociology of religion. This is especially the case regarding the recent increase in prominence of those identifying as “spiritual but not religious” (SBNR) within an American context. In the attempt to bring these two fields into productive conversation, this essay offers a constructive account of the SBNR in terms of what they reject (i.e., their status as “not religious”) and also what they affirm (i.e., their identity as “spiritual”). In brief, the suggestion is that the SBNR do not reject theism or even common “religious” practices, but instead reject a particular mode of “religion” that is grounded in an authoritative and insular social presence. Alternatively, the SBNR at least seem to affirm a notion of “spirituality” that is broadly consistent with the idea found in historical Christian traditions. After surveying the empirical data and offering a new phenomenological analysis of it, the essay concludes with a suggestion that we need a new category—“religious, but not spiritual” (RBNS)—in order best to make sense of how the SBNR signify in relation to specific hermeneutic contexts and sociopolitical frameworks.
Discharge Estimation Using Integrated Satellite Data and Hybrid Model in the Midstream Yangtze River
Authors: Xiong Jinghua , Guo Shenglian , Yin Jiabo
Published: June 2021

Remotely sensing data have advantages in filling spatiotemporal gaps of in situ observation networks, showing potential application for monitoring floods in data-sparse regions. By using the water level retrievals of Jason-2/3 altimetry satellites, this study estimates discharge at a 10-day timescale for the virtual station (VS) 012 and 077 across the midstream Yangtze River Basin during 2009–2016 based on the developed Manning formula. Moreover, we calibrate a hybrid model combined with Gravity Recovery and Climate Experiment (GRACE) data, by coupling the GR6J hydrological model with a machine learning model to simulate discharge. To physically capture the flood processes, the random forest (RF) model is employed to downscale the 10-day discharge into a daily scale. The results show that: (1) discharge estimates from the developed Manning formula show good accuracy for the VS012 and VS077 based on the improved Multi-subwaveform Multi-weight Threshold Retracker; (2) the combination of the GR6J and the LSTM models substantially improves the performance of the discharge estimates solely from either the GR6J or LSTM models; (3) RF-downscaled daily discharge demonstrates a general consistency with in situ data, where NSE/KGE between them are as high as 0.69/0.83. Our approach, based on multi-source remotely sensing data and machine learning techniques, may benefit flood monitoring in poorly gauged areas.
Snow Phenology and Hydrologic Timing in the Yukon River Basin, AK, USA
Authors: Pan Caleb G. , Kirchner Peter B. , Kimball John S. , Du Jinyang , Rawlins Michael A.
Published: June 2021

The Yukon River basin encompasses over 832,000 km2 of boreal Arctic Alaska and northwest Canada, providing a major transportation corridor and multiple natural resources to regional communities. The river seasonal hydrology is defined by a long winter frozen season and a snowmelt-driven spring flood pulse. Capabilities for accurate monitoring and forecasting of the annual spring freshet and river ice breakup (RIB) in the Yukon and other northern rivers is limited, but critical for understanding hydrologic processes related to snow, and for assessing flood-related risks to regional communities. We developed a regional snow phenology record using satellite passive microwave remote sensing to elucidate interactions between the timing of upland snowmelt and the downstream spring flood pulse and RIB in the Yukon. The seasonal snow metrics included annual Main Melt Onset Date (MMOD), Snowoff (SO) and Snowmelt Duration (SMD) derived from multifrequency (18.7 and 36.5 GHz) daily brightness temperatures and a physically-based Gradient Ratio Polarization (GRP) retrieval algorithm. The resulting snow phenology record extends over a 29-year period (1988–2016) with 6.25 km grid resolution. The MMOD retrievals showed good agreement with similar snow metrics derived from in situ weather station measurements of snowpack water equivalence (r = 0.48, bias = −3.63 days) and surface air temperatures (r = 0.69, bias = 1 day). The MMOD and SO impact on the spring freshet was investigated by comparing areal quantiles of the remotely sensed snow metrics with measured streamflow quantiles over selected sub-basins. The SO 50% quantile showed the strongest (p < 0.1) correspondence with the measured spring flood pulse at Stevens Village (r = 0.71) and Pilot (r = 0.63) river gaging stations, representing two major Yukon sub-basins. MMOD quantiles indicating 20% and 50% of a catchment under active snowmelt corresponded favorably with downstream RIB (r = 0.61) from 19 river observation stations spanning a range of Yukon sub-basins; these results also revealed a 14–27 day lag between MMOD and subsequent RIB. Together, the satellite based MMOD and SO metrics show potential value for regional monitoring and forecasting of the spring flood pulse and RIB timing in the Yukon and other boreal Arctic basins.
AirKit: A Citizen-Sensing Toolkit for Monitoring Air Quality
Authors: Mahajan Sachit , Gabrys Jennifer , Armitage Joanne
Published: June 2021

Increasing urbanisation and a better understanding of the negative health effects of air pollution have accelerated the use of Internet of Things (IoT)-based air quality sensors. Low-cost and low-power sensors are now readily available and commonly deployed by individuals and community groups. However, there are a wide range of such IoT devices in circulation that differently focus on problems of sensor validation, data reliability, or accessibility. In this paper, we present AirKit, which was developed as an integrated and open source “social IoT technology”. AirKit enables a comprehensive approach to citizen-sensing air quality through several integrated components: (1) the Dustbox 2.0, a particulate matter sensor; (2) Airsift, a data analysis platform; (3) a reliable and automatic remote firmware update system; (4) a “Data Stories” method and tool for communicating citizen data; and (5) an AirKit logbook that provides a guide for designing and running air quality projects, along with instructions for building and using AirKit components. Developed as a social technology toolkit to foster open processes of research co-creation and environmental action, Airkit has the potential to generate expanded engagements with IoT and air quality by improving the accuracy, legibility and use of sensors, data analysis and data communication.