bluuebunny/crossref_metadata_2025 huggingface dataset:
Research developments in the syntheses, anti-inflammatory activities and structure–activity relationships of pyrimidines
Authors: Rashid Haroon ur , Martines Marco Antonio Utrera , Duarte Adriana Pereira , Jorge Juliana , Rasool Shagufta , Muhammad Riaz , Ahmad Nasir , Umar Muhammad Naveed
Published: February 2021

This review sums up recent developments in the syntheses, anti-inflammatory activities, and structure–activity relationship (SAR) studies of pyrimidine derivatives.
Terahertz spectral investigation of temperature induced polymorphic transformation of 2,2dinitroethylene-1,1-diamine
Authors: Quancheng Liu , Qi Zhang , Guilin Li , Zhicheng Guo , Xiangyang He , chai Xie , Hu Deng , Liping Shang
Published: February 2021

The dynamic process of polymorphic transformations provides deep insights into the understanding of both the performance of explosives and its packing sensitivity.
From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer
Authors: Horst Frederico Hillesheim , Rodrigues Carime Vitória da Silva , Carvalho Pedro Henrique Pimenta Rocha , Leite Amanda Monteiro , Azevedo Ricardo Bentes , Neto Brenno A. D. , Corrêa José Raimundo , Garcia Mônica Pereira , Alotaibi Saud , Henini Mohamed , Chaves Sacha Braun , Rodrigues Marcelo Oliveira
Published: February 2021

Investigation of the immunological effect of light-up carbon-dots on cancer-bearing mice.
Modulating the stacking modes of nanosized metal–organic frameworks by morphology engineering for isomer separation
Authors: Xu Ming , Meng Sha-Sha , Cai Peiyu , Tang Wen-Qi , Yin Yun-Dong , Powell Joshua A. , Zhou Hong-Cai , Gu Zhi-Yuan
Published: February 2021

A morphology engineering method was utilized to modulate the stacking modes of three nano-NU-901 materials, leading to different separation abilities for isomers.
Infrared colloidal quantum dots for photoelectric conversion devices
Authors: Gong Wei , Wang Peng , Dai Dichao , Liu Zekang , Zheng Leyin , Zhang Yongzhe
Published: February 2021

This review summarizes diverse methods of performance improvement for infrared (IR) colloidal quantum dots (CQDs)-based photoelectric conversion devices, and provides guidelines for practical applications.
The influence of alkyl group regiochemistry and backbone fluorination on the packing and transistor performance of N-cyanoimine functionalised indacenodithiophenes
Authors: Hodsden Thomas , Thorley Karl J. , Basu Aniruddha , White Andrew J. P. , Wang Changsheng , Mitchell William , Glöcklhofer Florian , Anthopoulos Thomas D. , Heeney Martin
Published: February 2021

The influence of backbone fluorination and sidechain regiochemistry on an indacendithiophene (IDT) core containing electron withdrawing N-cyanoimine groups is investigated.
Retraction: Long noncoding RNA PTPRG-AS1 regulates growth of glioma cells by sponging miR-185-5p
Authors: Fisher Laura
Published: February 2021

Retraction of ‘Long noncoding RNA PTPRG-AS1 regulates growth of glioma cells by sponging miR-185-5p’ by Chenyang Xu et al., RSC Adv., 2019, 9, 10870–10880, DOI: 10.1039/C8RA09546A.
Pre-regulation of the planar chirality of pillar[5]arenes for preparing discrete chiral nanotubes
Authors: Fa Shixin , Adachi Keisuke , Nagata Yuuya , Egami Kouichi , Kato Kenichi , Ogoshi Tomoki
Published: February 2021

Pillar[5]arene-based chiral nanotube formation via pre-regulation of the building blocks' chirality is more efficient than post-regulating the chirality of nanotubes.
Optimal generation maintenance scheduling considering financial return and unexpected failure of distributed generation
Authors: Prukpanit Panit , Kaewprapha Phisan , Leeprechanon Nopbhorn
Published: February 2021

Generation maintenance scheduling (GMS) is an important factor that can improve the reliability of power systems and decrease revenue achieved by generation companies (GenCos). Several GMS models, therefore, are based on these two crucial values. Nonetheless, there is no GMS problem that simultaneously considers unexpected failure of distributed generator (DG), financial return of GenCo, and reserve of system. This paper proposes the GMS model based on a global criterion approach to compromise functions that maximise the GenCo’s annual return and probability that no DG fails unexpectedly. The system reserve (SR) is considered as a reliability constraint, while surplus reserve is exchanged with the main grid. To support alternative energy sources that have uncertain outputs and ensure continuous operation of DG, short‐term GMS model including power from wind farm, photovoltaic system, energy system storage, and demand response (DR) is also run by adding the SR and inconstant cost of DR. Effectiveness of the proposed model is examined using the IEEE 6 and IEEE 18‐bus test systems. Results show that not only the proposed model provides a better GMS solution for the GenCo, resulting in appropriate values of the two objectives, but also alternative energy sources are useful for the short‐term GMS.
Research on High-quality Development of Manufacturing Enterprises
Authors: Zhu Wei , Xu Yunfei
Published: February 2021

Through the analysis of the opportunities and challenges faced by the development of manufacturing enterprises, this paper proposes that the promotion of high-quality development is common trend driven by the current development of China’ manufacturing industry. This paper also refines the connotation, basic principles and overall ideas of high-quality development, and puts forward specific implementation paths and guarantee measures for manufacturing enterprises, providing reference and inspiration for manufacturing enterprises to achieve high-quality development.
Research on the Upgrading Path of Regional Equipment Manufacturing Industry
Authors: Li Yue , Qian Keyan , Sun Xiaoyan
Published: February 2021

Constructing the upgrading path of regional equipment manufacturing industry based on innovation network is of great significance for solving the transformation and upgrading problems of regional equipment manufacturing industry in China, further catching up with the development level of equipment manufacturing industry in developed countries, and alleviating the regional gap. Based on literature analysis and industrial upgrading theory, this paper puts forward the basic principles and general ideas of upgrading path design of regional equipment manufacturing industry, focusing on designing industrial upgrading path based on key common technologies, industrial upgrading path based on industrial chain optimization and industrial upgrading path based on innovation platform, and finally puts forward corresponding countermeasures and suggestions.
Analysis of Mid- and Long-term Incentive Policies for State-controlled Listed Companies
Authors: Wang Han , Wang Dan , Xu Yunfei
Published: February 2021

Equity incentives of listed companies are currently the most widely used medium and long-term incentives for state-owned enterprises. However, compared with general listed companies, the implementation of equity incentives for state-controlled listed companies is slightly behind due to the late introduction of the policy. This paper analyzes in detail the development context and related requirements of the relevant policies of state-controlled listed companies’ equity incentives, and provides an effective reference and reference for the state-controlled listed companies to carry out equity incentives.
Study on the impact of livelihood capital on farmers’ choice of forestland management mode —a case study of Fujian province
Authors: Li Jing , Chen Qin
Published: February 2021

Based on the survey data of 300 households in Fujian province, the system of farmers’ choice of forestland management mode was constructed by using the framework of sustainable livelihood analysis, and the impact of livelihood capital on farmers’ choice of forestland management mode was analyzed by using binary logistic model. The research shows that the factors of livelihood capital have different impact on the choice of forestland management mode. On this basis, the author puts forward some countermeasures to encourage farmers to improve their livelihood capital capacity, develop scale management and reduce their dependence on forestland income.
A Study on the Factors Influencing the Satisfaction of College Users on Logistics Services under the Structural Equation Model: Example of Jingdong Logistics in China
Authors: Zhang Guoxing , Cai Jiamin , Sun Yuhong
Published: February 2021

In this paper, the structural equation model is used to investigate the factors that affect the satisfaction of college students with Jingdong (JD) logistics. Based on the Swedish customer satisfaction index (SCSI) model and the American customer satisfaction index (ACSI) model, combined with their own actual needs, the model of college students’ satisfaction with JD Logistics is redefined. In this way, the scale indicators of the questionnaire survey are set. Combined with the research and empirical analysis of relevant literature, the initial model hypothesis was constructed, and six path hypotheses were proposed. The reliability and validity analysis confirmed that the questionnaire scale had high reliability and structural validity, and the structural equation model is also carried out. The fitting degree test confirmed that the structural equation hypothesis model has a high degree of fit, and verified the hypothesis established in the article, and finally put forward some countermeasures and suggestions for improving the service system of JD Logistics.
Research on the Influence of High-tech Industry Specialization Agglomeration on Innovation Efficiency
Authors: Nan Shuyang
Published: February 2021

In the new economic era with innovation as the first driving factor, high-tech industry, as an important industry support for innovation, its innovation efficiency will greatly affect the regional innovation level. In order to improve the innovation efficiency of the high-tech industry, the practice of accelerating the professional agglomeration of the industry has been widely adopted. What is the impact of high-tech industry specialization agglomeration on innovation level? Based on this, this paper constructs a theoretical analysis framework between industrial specialization agglomeration and innovation efficiency, and empirically analyzes it. The research results are as follows: there is an inverted U-shaped relationship between high-tech industry specialization agglomeration and innovation efficiency, that is, there is a specialized agglomeration scale, which makes industrial innovation efficiency reach the highest level. According to the empirical results, this paper provides a data level support for the proposal of industrial agglomeration policy.
Research on the Influential Factors of the Success of 7-ELEVEn in Japan
Authors: Lyu Anyi
Published: February 2021

Developing a new market from a country to another is a challenge for any manager. This study extends to research the new business model of 7-ELEVEn (7-11) that helps 7-11 adapt to different national conditions, grow customer demand and achieve great success in Japan. In this article, mixed methods including quantitative and qualitative study are used to discuss this topic. The business model of 7-11 in the both United States and Japan are investigated, aiming to find the reasons for its success in Japan. From this paper, it can be found that one of the main strategies that 7-11 makes is to develop their core competitiveness includes logistics operation and diversified service, which let them influence the society. Business model canvases in America and Japan are presented in this article, as well. As a result, not only the strategies of 711 but also the spirit of meeting the needs of customers and improving strategy with the trends should be learned by other countries.
Design and Development of Collaborative Office Automation System Based on Hierarchical Structure
Authors: Wang Chen , Feng Shuangchang , Liu Pengbo , Liu Xiaochang
Published: February 2021

In order to improve the work efficiency, this paper introduces a collaborative office automation system, and describes the main functional modules of the collaborative office automation system. It also describes the demand analysis and hierarchical system architecture design of the collaborative office automation system. The system has the characteristics of continuous and stable operation, which improves the work efficiency of the team and saves resources.
A Study of the Impact of Cloud Computing Alignment on the Enterprise Technological Capability Based on Environmental Turbulence
Authors: Shao MingXing , Yang XiaoHe
Published: February 2021

One of the most current concerns in the field of information system is whether cloud computing technology can deliver the desired improvement of capability and value to enterprises. This paper studied the enterprise technology development capability of the enterprises in Beijing Zhongguancun Technology Park, the first national high-tech industrial development zone in China, from the perspective of the breadth and depth of the alignment of cloud computing and enterprise. It proposed a theoretical model to study how the breadth and depth of alignment affects the enterprise technology development capability in a turbulent environment and considers the intermediary role of the enterprise technology absorption capability and the moderation role of environmental turbulence in it. The model was tested empirically by questionnaires and structural equation model (SEM). Empirical results showed that both the deep and wide alignment of cloud computing can enhance the enterprise technology development capability by improving the enterprise technology absorption capability.
Study on Patent Strategy of Emerging industry in China
Authors: Bao Meng-meng , Wu Jian-long
Published: February 2021

Patent strategy has become an important strategic means to elevate independent innovation capability and international competitiveness of emerging industry. Thus, based on connotation analysis of patent strategy of emerging industry, the paper designs influencing factors analysis framework for industry patent strategy, and puts forward industry patent strategy position, and then builds promoting process of industry patent strategy around patent development, application, use and protection, so as to provide theory and method support for patent strategy management of emerging industry.
The Upgrade and Transformation of Taiwanese-funded Enterprises in Guangdong under the New Normal
Authors: Zhang Yubing , Yixin Yan
Published: February 2021

Under the new economic normal, Guangdong Taiwan-funded enterprises are facing new challenges and opportunities in their upgrading and transformation. Taiwanese-funded enterprises should fully understand the impact of the new economic normal on their own development, actively adapt to the new normal, respond to new challenges, seize new opportunities, accelerate the transformation of development methods, adjust operation and development strategies, and accelerate the path of upgrading and transformation.
Analysis on the Status quo of Government subsidies for High-tech enterprises in China
Authors: Hanyi  , Li Yuju
Published: February 2021

In order to promote technological innovation of high-tech enterprises and speed up the process of enterprise innovation, the government has issued a series of subsidy policies. Among them, government subsidies can provide direct financial support for enterprises’ innovative research and development. The extent to which government subsidies cover high-tech enterprises and the use of government subsidies by enterprises have also attracted more and more attention. This article selects the high-tech companies from the Shanghai Stock Exchange and the Shenzhen Stock Exchange from 2010 to 2019, and studies the status quo of their government subsidies in terms of coverage, total distribution, use, and industries. It is found that the current high-tech companies have a high coverage of government subsidies and involve a wide range of industries, The financial support is relatively large, but different enterprises and industries are relatively unbalanced, and a relatively high proportion of government subsidies in enterprises are used for daily business activities. At the same time, it provides suggestions for the investment and utilization of government subsidies based on the research status.
Business Analysis on Sustainable Competitive Advantages
Authors: Wang Zeyu
Published: February 2021

With the rapid economic growth and globalization, sustainability begins to play a more and more important role in the strategic management of a company. This paper explains what the sustainability competitive advantages are, and what factors are related to sustainability. It also briefly introduces the sustainable competitive advantages from institutional and resource-based views. In addition, this paper presents that sustainable competitive advantages largely depend on the company’s capability to manage the institutional context of resource decision. Sustainable competitive advantages are not only related to internal context, but also related to external environment. This paper explains the link of sustainable competitive advantages in the internal and external environment. In conclusion, it presents the necessary understanding for entrepreneurs to concentrate on factors which influence corporate sustainability beyond numbers in the financial analysis.
Frontiers in the emerging development of blockchain and Bitcoin: visual research based on big data analysis
Authors: Pan Chung-Lien , Chen Zizhen , Zhou Zhixiang , Cai Zhuocheng , Liu Xuanyan , Lin Yiqi
Published: February 2021

In the era of the rapid development of information technology, the innovation of Fintech continues to send emerging research hotspots to the financial market. Based on the analysis of documents retrieved from the Web of Science database, this article provides a comprehensive data analysis and visualization of keywords such as “blockchain”, “bitcoin”, and “business and economic”. Using big data analysis technology and visual presentation, the author analyzed the details of the author’s keywords, popular organizations, countries, sources, and other key points of the correlation and external development status. Show the researchers the influence of the intersection of keywords, and point out the leading status of the organizations or countries with large resource occupancy in the research progress; at the same time, provide the researchers with an accurate grasp of the direction of the field and provide a reliable basis.
A Study on the Mechanism of Information Sharing between Customer Involvement and New Product Development
Authors: Xie Minglei
Published: February 2021

Data from 275 questionnaires were used to examine the role of information-sharing customers in value creation of new products. The results show that information sharing plays a part in mediating the relationship between customer participation and new product performance, and the two dimensions of information sharing enhance the interaction of new product performance. The above conclusions answer the mechanism of information sharing in the process of customer’s participation in the value creation of new products, reveal the interactive effect of “inside-out” and “inside-out” information sharing, and provide a reference for small and medium-sized enterprises (SMEs) in the manufacturing industry to participate in the development of new products.
Impact of “Internet plus” on manufacturing upgrading Based on evidence from Chinese manufacturing
Authors: Dai Xinyuan
Published: February 2021

Under the new economic normal, Internet plus initiatives has become the new engine of China’s economic transformation. Based on China’s manufacturing and Internet indicators from 2009 to 2016, this paper analyzes the impact of internet plus initiatives on manufacturing upgrading. The paper found a significant positive correlation between the Internet plus initiatives and the upgrading of the manufacturing industry, which shows that the Internet plus initiatives have a positive impact on the development of manufacturing.
The research of co-evolution mechanisms between cross-border e-commerce and manufacturing cluster: An Agent-based model
Authors: Qiu Li-ping , Yang Li-hua
Published: February 2021

China’s cross-border e-commerce industry presents the development trend as the service industry clusters, and interacts closely with the traditional manufacturing clusters. However, the mechanism for the coordinated evolution of the two kinds of clusters is not clear yet. This paper defines the cross-border e-commerce and the manufacturing cluster under collaboration as a complex socio-economic adaptation system that includes manufacturers, service providers, government behaviors and market demands. An agent-based collaborative model is designed by three types of agents and four driving interaction mechanisms, then the co-evolution mechanisms are observed and discussed in the process of dynamic evolution. Based on the rationality and feasibility of the model, the research explored the trend of co-evolution through scenario simulations and analysis, improved the mechanisms of co-evolution, and pointed out that cross-border e-commerce is one of the ways to transform and upgrade the manufacturing cluster. The conclusion of the study provides evolutionary ideas for export-oriented industrial clusters to coordinate with the cross-border e-commerce.
Research on the Connotation and Operation Mechanism of Smart Exhibition
Authors: Li Gan
Published: February 2021

The current development of China’s convention and exhibition economy is showing a new normal, under the background of the rapid development of information technology and the era of experience economy, the transformation and upgrading of the convention and exhibition industry will inevitably develop in the direction of informatization and intelligence, that is “smart exhibition”. This article takes the theoretical research related to the development status of smart exhibition as the starting point, studies and analyzes the connotation, elements and structure of smart exhibition, discusses the basic framework of smart exhibition, reveals the operation mechanism of smart exhibition, and forms some basic viewpoints and theories about smart exhibition.
The Innovation and development of Rural Revitalization: Agricultural Supply Chain Finance
Authors: Chen Zhang , Hui Li
Published: February 2021

Agricultural supply chain finance provides a feasible supply channel for the fund demand in rural economic development, alleviates the financing difficulties of small and micro enterprises and farmers in rural areas. However, there are also problems such as low standardization of agricultural products, imperfect credit risk system and incomplete information system, which seriously hinder the implementation of Rural Revitalization strategy. Financial product innovation is put forward in this paper, giving play to the role of government-led, perfect the premium subsidy, guarantees subsidy policy, actively into more involved in the main body, using the emerging technology industrialization construction, building ecological system resource sharing, expand the scope of services, to better precision power financial poverty alleviation, finally realizes the Rural Revitalization strategy.
The Design Path of the Project Income Dividend Plan of the State-owned Technology Enterprise
Authors: Wang Han , Huo Aimin
Published: February 2021

Project income dividend is one of the medium and long-term incentive methods commonly used by conventional technology enterprises, and it is also an important way for enterprises to stimulate technological innovation. In recent years, the number of state-owned technology-based enterprises that have distributed project income dividends has gradually increased, and they have all achieved good results. This article summarizes and sorts out the operating steps and common risks of project income dividends through analysis of the policy and practice of state-owned technology-based enterprise project income dividends. It provides an effective reference for the state-owned science and technology enterprises to carry out project income dividends.
The rise of tech giants in the fund sales industry: an example of how information and digital technology rebuild platform economy
Authors: Jiang Bowen
Published: February 2021

Unlike its American counterpart, the Chinese financial industry has been challenged by tech giants through their digital platforms. As the entrance of the asset management industry, the fund sales industry is at the center of the revolution, with commercial banks and tech giants fighting for its control. Some scholars have discussed the competition, but none of them discussed the competition by comparing their common features as platforms. Moreover, the competition is in a two-sided multihoming market that has long been ignored by scholars but will prevail in the future. With similar coverage rates for both fund managers and investors, how do fintechs use information and digital technology gobbling a big chunk of commercial banks’ profit. This article filled the gap by examining the common features of commercial banks and tech giants as platforms, including membership externality, usage externality, and multihoming behavior. Usage externality is crucial in this competition. It promoted market efficiency by unlocking the scale effect and using big data analysis. However, unlike the competition between other platforms, membership externality has little impact on the competition among commercial banks and tech giants. With prevailing multihoming behaviors to a high degree, newly entered platforms provided almost no additional membership externality.
Effectiveness of performance compensation commitment under Information Inequality
Authors: Zhou Yuhang
Published: February 2021

The demand of information society promotes the production of performance compensation commitment, which is used to alleviate the information asymmetry between investors and listed companies. The generation of performance compensation commitments has reduced valuation difficulties and other problems to a certain extent, lowered M&A costs and improved M&A efficiency. However, as the sample size increases, its drawbacks have gradually emerged. Youbo Pharmaceutical has stepped on the line for three consecutive years to achieve accurate performance. After the commitment period expires, the performance has dropped by more than 50%, so the authenticity of its performance has been questioned. Through the analysis of its announcement and various indicators, I find that the performance compensation commitment can not bring good market reaction after the commitment period, nor can it improve the integration effect, and even there are some behaviors such as premium, goodwill impairment risk and earnings management.
Thoughts on the Development of Accounting under the Background of Informationization
Authors: Shui Jiang
Published: February 2021

In the present era, information technology continues to develop in-depth. Some new technologies, such as Big Data and cloud computing are emerging, constantly changing our lives. In this context, information technology has gradually penetrated the accounting field, profoundly changing the accounting industry’s development process, and has brought huge challenges to accountants. This paper addresses the challenges that information technology brings to the accounting industry and gives corresponding countermeasures to promote accounting’s better development.
Residents' Perceptions of Economic Impacts of Tourism Development in Vrnjačka Banja, Serbia
Authors: Đorđević Nataša , Milićević Snežana
Published: February 2021

Research background: Tourism has become a favorable industry for many countries, considering the benefits it generates. The important part in reaching sustainability in tourism is to know how the local population perceives the effects of tourism. Tourism brings economic benefits, and on the other side it involves some economic costs, including government costs for infrastructure to better serve tourists, costs for local residents such as increased prices of goods and services, real estate, it generates seasonal unemployment, etc.

Purpose of the article: The aim of this study is to investigate how residents perceive the economic impacts of tourism development in Vrnjačka Banja.

Methods: Methods: The survey method was used to collect primary data. Data were processed by SPSS Statistics 23. The 14 defined statements of the economic impacts of tourism were subjected to Factor analysis. The internal consistency of the sample was carried out the Cronbach alpha coefficient.
Findings & Value added: Results indicate that respondents perceive those impacts as more positive. Giving the fact that no research can be found in the scientific literature about how residents perceive the economic benefits and cost of tourism development in spa destinations, this study contributes to this field of study.
Research on the involvement of residents and tourists in protecting the local brand as a sustainable destination
Authors: Serban Mădălina , Turek Rahoveanu Maria Magdalena , Zugravu Gheorghe Adrian , Băniţă Cornel
Published: February 2021

Research background. Specialists show a decrease in awareness of the issues of sustainability of tourism activities among various stakeholders [1], followed by arguments [2], and irresponsible practices of visitors.

Local key actors could be the main interdependent factors in solving [3] these issues that characterize sustainable tourism through the emergence of the phenomenon of digitalization and high popularization of social networks.

Digital communication networks have left their mark on the impact that brand tourism - considered as local tourist destinations, has on the behavior of residents and tourists [5], [6].

In this research we aim to evaluate the various advantages that sustainable tourism can have due to digital media in the Pietroasele area, Buzau County, Romania.

Purpose of the article. In this research we aim to evaluate the various advantages that sustainable tourism can have due to digital media in the Pietroasele area, Buzau County, Romania.

Methods. Digital communication networks have left their mark on the impact that brand tourism - considered as local tourist destinations, has on the behavior of residents and tourists [7],[8],

Findings & Value added. The aim of this study is to evaluate the perceptions about the local brand as a way to attract entrepreneurs, tourists and business development in the wine area Pietroasele, Buzau, Romania based on the following specific research objectives:
1. Knowledge of the role of the local brand in the management of local businesses and authorities.
2. Monitoring the application of mechanisms used by specialists to develop local branding, including collaboration with local partners.
3. Evaluation of the perspectives arising from the development of the analyse brand.
BNO 1095, a Standardized Dry Extract from the Fruits of Vitex agnus-castus, Impairs Angiogenesis-related Endothelial Cell Functions In Vitro
Authors: Bischoff-Kont Iris , Brabenec Laura , Ingelfinger Rebecca , Nausch Bernhard , Fürst Robert
Published: February 2021

BNO 1095, a standardized dry extract from the fruits of Vitex agnus-castus, represents an approved herbal medicinal product for the treatment of premenstrual syndrome. Angiogenesis, the formation of new blood vessels from pre-existing capillaries, plays a major role in physiological situations, such as wound healing or tissue growth in female reproductive organs, but it is also of great importance in pathophysiological conditions such as chronic inflammatory diseases or cancer. Angiogenesis is a highly regulated multi-step process consisting of distinct key events that can be influenced pharmacologically. Few studies suggested anti-angiogenic actions of V. agnus-castus fruit extracts in in vivo and ex vivo models. Here, we provide for the first time profound in vitro data on BNO 1095-derived anti-angiogenic effects focusing on distinct angiogenesis-related endothelial cell functions that are inevitable for the process of new blood
vessel formation. We found that V. agnus-castus extract significantly attenuated undirected and chemotactic migration of primary human endothelial cells. Moreover, the extract efficiently inhibited endothelial cell proliferation and reduced the formation of tube-like structures on Matrigel. Of note, the treatment of endothelial cell spheroids almost blocked endothelial sprouting in a 3D collagen gel. Our data present new and detailed insights into the anti-angiogenic actions of BNO 1095 and, therefore, suggest a novel scope of potential therapeutic applications of the extract for which these anti-angiogenic properties are required.
Are Absence and Limbic Seizures Mutually Exclusive?: An Experimental Approach to Enigmatic Clinical Concept
Authors: Onat Filiz Yılmaz , Eşkazan Esat
Published: February 2021

The impressive advances in the several disciplines including neurophysiology, molecular biology, neuroimmunology, neurogenetics, neuroimaging, and neuropharmacology of epilepsies have been stimulating a mutual interaction among basic scientists, clinicians, and professionals from other disciplines, leading to the identification of clinical questions and then the design of basic science paradigms to test enigmatic clinical issues. Based on a clinical observation that the coexistence of genetic (idiopathic) generalized typical absence and mesial temporal lobe epilepsy in the same patient is extremely rare and debatable, we addressed the rare coexistence in the same individual, designed an experimental approach to test the validity of this clinical concept and to study the underlying mechanisms involved. Here we presented evidence of a mutual cross-interaction in the circuits involved in typical absence and temporal lobe epilepsy. This article delineates a phenomenological picture and comprehends a theoretical understanding of a mutual cross-interaction in typical absence as a representative of genetic generalized epilepsies and limbic epilepsy in which seizures often start from the mesial temporal lobe.
A Variant in SLC25A4 Leads to Mitochondrial DNA-Depletion Syndrome-12A Causing Neonatal Hypotonia and Hypoventilation
Authors: Sanghvi Kishore Pratap , Bajaj Shruti , Mirani Sonal
Published: February 2021

Congenital hypotonia and hypoventilation is a rare association. We report a rare case of a female newborn with poor respiratory drive, ventilator dependency, severe hypotonia, cardiomyopathy, and premature death. Clinical-exome-sequencing revealed SLC25A4-related mitochondrial deoxyribonucleic acid (DNA) depletion syndrome-12A (cardiomyopathic type). This syndrome is apparent at birth and carries a poor prognosis.
Exploring linguistic features, ideologies, and critical thinking in Chinese news comments
Authors: Gao Yang , Zeng Gang
Published: February 2021

This study explores linguistic features, ideological beliefs, and critical thinking in news comments, which are defined as the comments from readers to news posts on social media or platforms. Within the overarching framework of critical discourse analysis, a sociocognitive approach was adopted to provide detailed analyses of the studied constructs in sampled news comments. In terms of the data collection and analysis, sampled social media, news columns, and news comments were selected, and then 19 college students were interviewed for their responses to different news topics. The primary findings of the study include: (1) personal and social opinions are representations of ideological beliefs and are fully presented through news comments, (2) these personal and social ideological beliefs may diverge or converge due to critical thinking, (3) critical thinking helps commenters form their personal and social ideologies, and then helps them choose the linguistic forms they believe fit their news comments, (4) news topics, however, vary in informing commenters’ critical thinking ability. Finally, a sociocognitive model for studying linguistic forms, ideologies, and critical thinking was proposed in the study.
Advantages and limitation of Mn doped PIN–PMN–PT single crystals in pyroelectric detectors
Authors: Neumann N. , Kaiser A. , Mutschall D.
Published: February 2021

The outstanding pyroelectric coefficient p of Mn:PIN–PMN–PT makes it an interesting material for application in pyroelectric infrared detectors. In comparison to the standard material lithium tantalate (LT), the pyroelectric coefficient is higher by a factor of 4. On the other hand, the dielectric permittivity εp is about one order of magnitude higher compared to LT. Due to the higher permittivity, the resulting Figures of Merit (FOM) show the highest performance advantages for Mn:PIN–PMN–PT in the lower frequency range between 1 Hz and 10 Hz. The FOM FR of 278 · 10−12 m/V exceeds by half an order of magnitude the value of LT of 54 · 10−12 m/V. Outstanding specific detectivities around D* ≈ 1.0 · 109 cm√Hz/W at low frequencies even at a relatively low chip size were achieved. The detector fabrication needs adaption of the processes to avoid depolarization due to high temperature impact or mechanical stress.
Comparative performance analysis of bearingless switched reluctance motor
Authors: Yang YiFei , Sun Liang , Zhu XiaoBin , Hu DeLin
Published: February 2021

To solve the magnetic field coupling problem in the traditional bearingless permanent-magnet motor, which has magnets on the rotor, we propose two topologies of bearingless switched reluctance motors (BLSRMs) with magnets on the stator yoke. The first is a six/four-pole BLSRM with three pairs of permanent magnets on the stator and the second is a six/four-pole BLSRM with one pair of stator yoke magnets. First, the working principle of BLSRMs is introduced, including the structure and winding configuration, and the mechanism of generating levitation force is analyzed in detail. Based on 2D finite element analysis, the electromagnetic characteristics of the prototype are compared, including torque, suspension force, no-load back EMF, and no-load permanent magnet linkage. The calculation results show that at high speeds, the coupling between the levitation force winding and the torque winding of the BLSRM with one magnet pair is low, which allows for better decoupling performance and greater levitation force. In addition, although the motor with three pairs of permanent magnets in the stator yoke shows better torque performance, the loss of the motor is higher at a high speed. The research results lay a theoretical foundation for further research on a new type of bearingless motors.
Experimental and numerical research on a novel underwater launching method with high efficiency and low resistance
Authors: Zhang Xinwei , Yu Yonggang
Published: February 2021

This paper describes an experimental and a numerical study of a recently developed high-efficiency, low-resistance launching method for an underwater launcher. The so-called gas-curtain launch method overcomes the problems of poor safety and low muzzle velocity in traditional fully submerged launchers. By introducing part of the gas inside the chamber to the front of the projectile, the water inside the barrel will be driven out. A low-resistance gas passage is then provided for projectile motion in the bore, thus delivering better interior ballistics performance than that in fully submerged launchers. Experiments are carried out using a 12.7-mm underwater launcher. A pressure sensor is used to record the chamber pressure, and high-speed video recordings allow the projectile motion around the muzzle to be determined. The experimental results show that the muzzle velocity is 172.8 m/s and the maximum chamber pressure reaches 116.0 MPa in a fully submerged launch, compared with a maximum chamber pressure of only 41.8 MPa and a muzzle velocity of 177.5 m/s when the gas-curtain launch method is adopted. The significant drag reduction effect of the gas-curtain launch greatly improves the interior ballistics performance, reducing the maximum chamber pressure by about 64.1% while retaining a similar muzzle velocity. Following the experiments, a numerical model is established and simulations are performed under various ventilation mass rates. The results clarify the drag reduction mechanism and the partial characteristics of the flow field in the gas-curtain launch.
Pattern formation and polarity sorting of driven actin filaments on lipid membranes
Authors: Sciortino Alfredo , Bausch Andreas R.
Published: February 2021

Significance

Pattern formation processes in active systems give rise to a plethora of collective structures. Predicting how the emergent structures depend on the microscopic interactions between the moving agents remains a challenge. By introducing a high-density actin gliding assay on a fluid membrane, we demonstrate the emergence of polar structures in a regime of nematic binary interactions dominated by steric repulsion. The transition from a microscopic nematic symmetry to a macroscopic polar structure is linked to microscopic polarity sorting mechanisms, including accumulation in wedge-like topological defects. Our results should be instrumental for a better understanding of pattern formation and polarity sorting processes in active matter.
Non-destructive measurement of leaf area and leaf number of hydroponic pak-choy plants (Brassica rapa)
Authors: Nasution I S , Satriyo P , Ichwana  , Yolanda S , Alma A
Published: February 2021

Leaf area and leaf number is an important factor in many agronomic and plant physiological studies. The measurements are commonly obtained by destructive and time consuming via laboratory. Therefore, there is a trend in utilizing fast and non-destructive methods to estimate leaf area and leaf number. The aim of this study was to estimate leaf area and leaf number of pak choy (Brassica rapa) under field condition. For this purpose, 180 pots of pak choy plants were captured. Afterward, the images were analysed via image processing. Distance transform-watershed segmentation was used to extract and to separate every leaf from its background. The area of each leaves were estimated according to the pixel values obtained. The area of leaves also compared to the ImageJ measurement. The number of extracted leaves was evaluated according to precision, recall, and f-measure calculation. In conclusion, our system achieves a good performance for minimal occlusion leaves and provides quick and non-destructive method. This method could potentially be applied to design phenotyping system in the greenhouse even for small scale companies.
Chemical and sensory properties of local Aceh rice (Oryza sativa L.) M4 mutant resulting from Gamma-ray irradiation
Authors: Hayati R , Efendi
Published: February 2021

The chemical characteristic of Aceh local rice (Oryza sativa L.) is largely determined by the moisture content, protein, ash and amylose. On the other hand, sensory indispensable to determine the level of acceptance of a product. This study aims to determine chemical analysis and sensory of Aceh local rice mutant M4 from gamma-ray irradiation results. The results showed that M4 mutant rice had a very significant effect on the chemical characteristic, amylose and protein, and significantly affected to the ash content. The best amylose content was the USK-Snb-RGO-238-063-057e-217 strain, while the protein content in rice was USK-Snb-RGO-238-094-088j-140 and the best ash content was USK-Snb-RGO-238- 016- 057d-106. The Aceh local rice mutant M4 has a significant effect on inner color, outer color, texture and overall acceptance and has a significant effect on the shape of rice. The rice received by the panelists, namely rice USK-Snb-RGO-238-063-057e-217.
Chemical compounds identification of Rice cultivars in West Sumatra
Authors: Makky M , Santosa  , Cherie D , Putri R E , Hasan A
Published: February 2021

In West-Sumatra, rice farming commonly uses five significant cultivars, namely Simauang; Randa Pulau; Bakwan; Junjuangan; and Mundam. They are superior in yields and adaptable to the local climate. In this study, the chemical properties of five cultivars were investigated to identify the composition of protein, carbohydrate, ash, and moisture content. Furthermore, the effects of heat exposure to rices were observed as well, where products typically untreated when being stored. The research investigated how heat exposure may influence shelf life and rice quality. Results show that there are significant differences in chemical contents that occur due to differences in cultivars, storage treatment, and mechanical damage. The most chemical composition that changed when given treatment was Mundam and Simaung cultivars. The chemical composition that changed in Mundam cultivar is MC, Fat, and, Carbohydrate while in Simaung Fat, Ash, and Carbohydrate. Before giving heat treatment, Mundam rice contained the highest and lowest protein 9,617% and 79.37%. Simauang rice has low protein with a high carbohydrate of 6,343% and 81,472%. After giving heat treatment, the protein and carbohydrate of the Mundam changed to 10.207% and 78.666%. Simaung's protein did not change but protein, 6.284%, and 81.541% for carbohydrates. Carbohydrate has changed due to size and type of cultivar. The protein has changed due to cultivar influence, treatment, and size.
Quality study of dried Peda fish using a greenhouse effect vent dryer
Authors: Agustina R , Mustaqimah  , Nurba D , Yasar M , Itawarnemi
Published: February 2021

The purpose of this study was to examine the physical and chemical characteristics of peda Tenggiri fish. Peda is a traditional processed fish product that is made by salting and then followed by fermentation. Types of fish commonly made peda include Tenggiri fish. The method used in this research was experimental and the parameters analyzed were air content, salt content, acid insoluble ash, and organoleptic. The results obtained from the initial water content of T enggiri fish reached 3 7%, it can be denied that the water content of dried peda fish in Lhokseudu village has reached SNI (8273: 20016). Based on research, the initial salt content in Tenggiri fish ranges from 3.02%, the proportion that meets the Standard National Indonesian (SNI) so that it is still safe to use. The acid-insoluble ash content of Tenggiri fish reached 5.26% during the 23-hour drying process, the acid insoluble ash content increased, therefore the acid insoluble ash content did not meet the SNI standard.