bluuebunny/crossref_metadata_2025 huggingface dataset:
Clasificación anatómica: una propuesta para categorizar las fisuras labiopalatinas
Authors: Leiva Noemí , Stange Carolina , Ayala Francisca , Fuentes Vanessa
Published: October 2019

El origen de una clasificación para las fisuras labiopalatinas se remonta desde comienzos del siglo XX. Muchos de los sistemas propuestos por diversos autores no han prosperado, principalmente debido a su complejidad para memorizar y registrar. Esta nota científica resume las clasificaciones de fisuras labiopalatinas más populares entre los profesionales de la salud y además propone una nueva, basada en aspectos anatómicos y morfológicos de las fisuras en los pacientes, la Clasificación Anatómica. Esta clasificación, diseñada y utilizada por la Unidad de Malformaciones Craneofaciales de la Universidad de Chile, busca entregar una solución a esta problemática, categorizando las fisuras, de manera simple y descriptiva, según los tejidos comprometidos (labio, paladar, labiopalatinas), si su manifestación clínica es poco prevalente (atípicas) o si se encuentran asociadas a algún síndrome (sindrómicas).
Diseño y evaluación de la expresión de una potencial vacuna de ADN contra el virus de la Tilapia de Lago (TiLV)
Authors: Criollo Joaquin Mónica Paola , Motte Emmerik , Salvatierra Max , Medina Jorge , Diringer Benoit , Sandoval Gustavo , Mialhe Eric
Published: October 2019

El Virus de la Tilapia del Lago (TiLV), es un patógeno causante de mortalidades masivas tanto en poblaciones de tilapias cultivadas y silvestres alrededor del mundo. El desarrollo de una vacuna efectiva contra este patógeno emergente es imperativo para prevenir pérdidas económicas. En este trabajo se diseñó y evaluó un vector de expresión como una potencial vacuna de ADN contra este virus. Inicialmente, se realizó un análisis de enhebramiento para predecir las estructuras tridimensionales y las funciones de las proteínas del TiLV. Se encontraron homologías estructurales entre las proteínas correspondientes al segmento genómico 1 y al segmento genómico 4 del TiLV, con las proteínas de ARN polimerasa dependiente de ARN del virus de la influenza B (56%) y la proteína neuraminidasa que pertenece a la cápside del virus de la influenza A (12%), respectivamente. Se insertó el producto de PCR del gen neuraminidasa viral en el vector plasmídico de expresión pCMV. Finalmente, se inyectó el constructo plasmídico en juveniles de la tilapia del Nilo Oreochromis niloticus y se midió su expresión mediante RT-PCR en tiempo real a las 8h, 16h, 24h, 72h después de la segunda inyección inmunizante. Se logró detectar expresión génica en los cuatro tiempos evaluados, con mayor expresión a las 16 horas post inyección. Estos resultados constituyen el primer paso para el desarrollo de una vacuna efectiva para la protección de los stocks de tilapias alrededor del mundo.
Escarabajos coprófagos (Coleoptera: Scarabaeidae: Scarabaeinae) en la reserva El Zapotal, Chiapas, México
Authors: Rodríguez-López M. Edivaldo , Sánchez-Hernández Gibrán , Gómez Benigno
Published: October 2019

El Centro Ecológico y Recreativo El Zapotal (CEREZ) se caracteriza por presentar uno de los últimos remanentes de selva mediana en la región central de Chiapas, México. Sin embargo, el conocimiento de algunos grupos taxonómicos de la reserva no es del todo adecuado. En este trabajo se analiza la composición y estructura, así como la distribución temporal de los escarabajos coprófagos que habitan en el CEREZ. Se realizaron muestreos mensuales entre febrero de 2013 y enero de 2014 utilizando trampas de caída cebadas con estiércol de seis especies de mamíferos que se mantienen en cautiverio al interior del Zoológico Miguel Álvarez del Toro (ZooMAT). Se presenta una lista anotada de 22 especies agrupadas en 12 géneros y seis tribus de Scarabaeinae. Onthophagus anthracinus, Canthon femoralis, Onthophagus landolti y Copris laeviceps aportan el 89.7% de la abundancia total. La curva de rarefacción muestra una tendencia asintótica, con un 92% de completitud. La fauna capturada muestra una marcada distribución temporal (p < 0.01), observando los valores más altos de riqueza y abundancia durante los meses de la temporada lluviosa. Los registros representan el 7.53% de la diversidad conocida en México y el 18.2% de las especies reportadas en el estado de Chiapas. A pesar de representar un pequeño remanente de selva tropical y de la constante presión antrópica generada por la zona urbana, El Zapotal conserva una fauna de escarabajos coprófagos representativa a nivel regional, resaltando la importancia de la reserva como refugio de especies.
Characteristics of time-transgressive Holocene Optimum in the East Asian monsoon region
Authors: Weihe Ren , Yi Guitian
Published: October 2019

The Holocene Optimum (HO) defines a relatively warm and wet period during the Holocene, the initial and termination ages of which have been extensively reported for East Asia; however, debates still focus on underlying spatial and temporal patterns. Here, latest paleoclimate records from the East Asian monsoon region and arid central Asia are synthesized to evaluate the spatial and temporal patterns of the HO. The results of this synthesis indicate that the latitude and both the initial and termination ages of the HO follow a strong relationship, which is an expansion and northward retreat of the HO except for records around the Tibetan Plateau and several other highlands. Both the HO and technological development are also suggested to have shaped the historic boom of the Neolithic human demography. This study provides a window toward an improved understanding of the characteristics of time-transgressive HO and allows to make predictions for the initial and termination ages of the HO at different geographical locations of the East Asian monsoon region.
Measurement of radon in soils of Lima City - Peru during the period 2016-2017
Authors: Lázaro Luís Vilcapoma , López Herrera María Elena , Pereyra Patrizia , Fernández Daniel Palacios , Pérez Bertin , Rojas Jhonny , Sajo-Bohus Laszlo
Published: October 2019

Lima City is situated on alluvial fan deposits of rivers flowing through geological formations that contain different levels of uranium. In this paper, a study is made on the average spatial and temporal behavior of radon gas in soils of Lima City. Radon concentration was determined using the LR-115 type 2 track detector during 36 periods, of 14 days each, in twenty holes distributed in the fifteen districts of Lima City. Radon concentration in soil pores ranged from 0.1 to 64.3 kBq/m3 with an average value of 5.6 kBq/m3. The average radon concentration in soil gas was about two times lower in winter than in the other seasons. High radon values during October/November 2017 were related to the earthquakes perceived in Lima City in that period. The highest radon concentrations were found in areas of alluvial deposits whose parental material has been removed from the Quilmaná and Huarangal volcanics by the Chillón and Huaycoloro Rivers. Soil gas radon concentrations were even higher in areas closer to volcanic and less distant from rivers. During the period of maximum flooding of the Chillón, Rímac and Lurín rivers, due to the natural phenomenon “El Niño Costero”, anomalous high soil radon concentrations were observed in most of the measurement sites located near rivers. These high radon values were associated with ground vibrations caused by rock and debris avalanches in rivers and creeks.
The Oral Microbiota: A Literature Review for Updating Professionals in Dentistry. Part I
Authors: Barboza-Solís DDS, MSc, PhD Cristina , Acuña-Amador PhD Luis Alberto
Published: October 2019

In recent decades, a body of literature examining the relationships between oral health and general health has rapidly developed. However, the biological mechanisms involved in explaining such relationships have not been fully described. Recent evidence has suggested that these relationships could be partially explained by the composition and interaction of the microbiome/microbiota between local and systemic body sites. For instance, it has been suggested that intestinal microbiota could have effects on non-communicable diseases, such as diabetes or cardiovascular diseases. The objective of this study is to explore current evidence of the link between oral and systemic diseases, to discuss whether oral microbiome/microbiota could represent an unexplored biological pathway partially explaining those relationships. A non-systematic review of the literature was carried out using keyword searches in Pubmed from February to May 2019. The ultimate goal was to present recent scientific evidence to update the general knowledge on this topic to professionals in dentistry. This review is divided in two parts for journal publication; however, it is intended to be used as one piece. In this first part, we will summarize the conceptual background of oral microbiome/microbiota, we will describe the main methods used in microbiology to characterize oral organisms, and will present the main composition of bacteria in oral microbiome/microbiota. The second part highlights the main evidence regarding the biological plausibility that links oral microbiome and systemic diseases and we will conclude with some future research recommendations. Taking into account the role of oral microbiota in the development of systemic diseases could change the main paradigm of how oral health is currently conceptualized by dental professionals.
Language Teacher Education and Technology: Approaches and Practices, edited by Jeong-Bae Son and Scott Windeatt
Authors: Mei Bing
Published: October 2019

Language Teacher Education and Technology: Approaches and Practices

Edited by Jeong-Bae Son and Scott Windeatt

London: Bloomsbury Academic

US $170.99

ISBN: 978-1350020405 (Hardback)

187 pages

2017
Language, Education and Technology (3rd Ed.), edited by Steven L. Thorne and Stephen May
Authors: Quinlan Jennifer
Published: October 2019

Language, Education and Technology (3rd Ed.)

Edited by Steven L. Thorne and Stephen May

Cham, Switzerland: Springer

US $349.99

ISBN 978-3-319-02236-9 (Hardback)

472 pages

2017
Potential and methods of target cholesterol level achievement in daily clinical practice: results of the Russian multi-centre observational study “TREAT TO GOAL”
Authors: Konstantinov V. O.
Published: October 2019

Aim. To study potential therapeutic approaches to the management of coronary heart disease (CHD) patients with hypercholesterolemia (HCH), who receive statins, but do not achieve target levels of total cholesterol (TCH) and low-density lipoprotein cholesterol (LDL-CH) in daily clinical practice. Material and methods. The research project “Treat To Goal” is an observational study, involving 10 clinical centres in 6 Russian cities. In total, the study included 712 patients with CHD and HCH (386 men and 324 women; mean age 59 years), who received statins as secondary prevention measure, but did not achieve target levels of TCH and LDL-CH. Results. In order to achieve target TCH levels, the lipid-lowering therapy was modified as follows: 42,4 % patients were administered a new statin; in 32,1 %, the “old” statin dose was titrated; in 25,5 %, statin therapy was combined with ezetimibe. The target TCH levels were achieved, respectively, in 33,5 %, 37,4 %, and 50,4 % of the patients. All three types of therapy modification were well tolerated and safe.

Conclusion. Combined lipid-lowering therapy with ezetimibe and statins is the optimal treatment option for Russian patients with CHD and HCH, who otherwise cannot achieve the target levels of blood lipids.
Anti-ischemic and antiarrhythmic effectiveness of long-term bisoprolol therapy in patients with myocardial infarction
Authors: Shukurov R. T. , Kurbanov R. D.
Published: October 2019

Aim. To study the effects of long-term bisoprolol (B) therapy on exercise capacity (EC) dynamics, ventricular arrhythmia (VA), and clinical course in patients with myocardial infarction (MI). Material and methods. The study included 114 men with MI (age 30-63 years), receiving long-term B treatment (2,5-10 mg once a day). The parameters assessed included EC dynamics, VA, and clinical course of the disease. Results. Patients with sub-acute MI were characterised by low EC and VA presence, including life-threatening VA forms. Long-term B treatment was associated with a significant reduction in angina attack rate (by 3,9 times) and in the number of nitroglycerin tablets per week (by 4,3 times). In most patients (79,7%), B therapy increased the work performed during stress test (+99%), EC (+43,4%), and exercise time (+52%). In 44 patients (55,7%), an antiarrhythmic effect was observed, including the individuals with high-grade VA (13 out of 15). Long-term B treatment also improved the clinical course of the disease, significantly reducing the end-point rates (in 86,1%). Conclusion. Early started, adequate-dose long-term B therapy improved clinical course of the disease and demonstrated good anti-ischemic, antianginal, and antiarrhythmic effects in MI patients, including those with life-threatening VA forms.
Combined antihypertensive therapy in patients with arterial hypertension and coronary heart disease
Authors: Ageenkova O. A. , Milyagin V. A. , Purygina M. A.
Published: October 2019

Aim. To assess the potential of adding perindopril and indapamide CR (controlled release) to standard therapy, as a method for additional correction of cardiovascular risk factors (RFs) among patients with Stage 1-3 arterial hypertension (AH) of very high risk and coronary heart disease (CHD). Material and methods. In total, 44 patients (29 men, 15 women; age 45-80 years, mean age 56±10,7 years) with Stage 1-3 AH of very high risk and CHD were examined. At baseline and after 2, 4, and 16 weeks of the treatment, all participants underwent physical examination, office blood pressure (BP) measurement, standard laboratory tests, electrocardiography (ECG), Holter ECG monitoring, 24-hour BP monitoring, echocardiography (EchoCG), and arterial stiffness assessment. Results. All participants completed the study protocol, with no adverse effects during the treatment phase. In all patients with Stage 1-3 AH, target BP levels and improved 24-hour BP profile were achieved. In CHD patients, a reduction in the incidence of ischemic episodes and their duration was observed. There was a positive dynamics of arterial stiffness parameters. Conclusion. Perindopril and indapamide CR demonstrated good antihypertensive effectiveness, as well as cardioand vasoprotective activity in patients with very high-risk AH and CHD.
Two strategies for arterial hypertension treatment in patients with secondary chronic pyelonephritis
Authors: Statsenko M. E. , Derevyanchenko M. V.
Published: October 2019

Aim. To compare the antihypertensive effectiveness, cardio- and nephroprotection, and metabolic effects of the combinations “enalapril + indapamide” vs. “enalapril + nifedipine slow release (SR)” in patients with arterial hypertension (AH) and secondary chronic pyelonephritis (CPN). Material and methods. In total, 60 patients with AH and secondary CPN, aged 45-65 years, were divided into two groups: Group I (n=30) receiving combined therapy with enalapril (mean dose 15,9±2,3 mg/d) and indapamide (2,5 mg/d); and Group II (n=30) receiving the combination of enalapril (16,1±2,4 mg/d) and nifedipine SR (40 mg/d). The complex examination included 24-hour blood pressure monitoring (BPM), echocardiography, measurement of morning urine specific gravity, microalbuminuria (MAU), urine levels of ß2-microglobulines, blood creatinine and glomerular filtration rate (GFR) calculation by MDRD formula, fasting glucose, potassium, uric acid, total cholesterol, and triglycerides. The follow-up time was 12 weeks. Results. The combinations “enalapril + indapamide” and “enalapril + nifedipine SR” had similar effects in terms of BP lowering, MAU reduction, and improvement of proximal renal tubular function. In both groups, there was a decrease in the number of patients with circadian BP rhythm disturbances, adverse left ventricular remodelling types, or diastolic dysfunction. The combination of enalapril and indapamide was significantly more effective in terms of restoring renal concentrating function, compared to the combination “enalapril + nifedipine SR”. Both antihypertensive therapies were metabolically neutral, not affecting carbohydrate, purine, lipid, or electrolyte metabolism parameters.

Conclusion. The combinations “enalapril + indapamide” and “enalapril + nifedipine SR” demonstrated high antihypertensive effectiveness, cardio- and nephroprotection, and metabolic neutrality.
Acute vascular effects of the angiotensin II receptor antagonist olmesartan in normal subjects: relation to the renin-aldosterone system
Authors: Resnick L. M. , Catanzaro D. , Sealey J. E. , Laragh J. H.
Published: October 2019

The extent to which the clinical effects of angiotensin receptor blockers (ARB) are related to ambient renin system activity remains poorly defined. Therefore, we measured blood pressure (BP), large (C1) and small (C2) arterial compliance, systemic vascular resistance (SVR), plasma renin activity (PRA), and the 24-h urinary excretion of sodium (UNaV) and aldosterone before and 1, 2, 4, and 24 h after administration of single doses of placebo, and 5, 20, and 40 mg of the ARB olmesartan medoxomil to 12 unmedicated normotensive subjects. In the basal state, SVR was inversely related to UNaV (r=-0,3,p=0,04); the greater the UNaV, the more vasodilated the subject. Indices of arterial compliance, both C1 (r=-0,32,p=0,03) and C2 (r=-0,35,p=0,02) were inversely related to the basal PRA. Renin also predicted olmesartan-induced changes in C1 (r=0,43,p=0,004) and C2r=0,33,p=0,04). The greater the basal PRA, the less the arterial compliance, and the more compliance improved after olmesartan. Both systolic (p=0,003) and diastolic (p<0,0001) BP fell significantly on olmesartan compared with placebo (MANOVA with time), and relations were observed between the basal PRA and olmesartan-induced changes in pressure (systolic BP:r=-0,414,p=0,012; diastolic BP:r=-0.561,p<0,0001) — the greater the initial PRA, the more olmesartan lowered BP. Furthermore, the more pressure fell, the more PRA rose reciprocally (r=-0,44,p=0,007). Finally, aldosterone excretion fell (sig=0,05) on each dose of olmesartan compared with placebo. We conclude that 1) the inverse relation of UNaV and SVR illustrates the reciprocal role of volume versus constrictor factors in maintaining normal BP; and 2) PRA is a physiologic determinant of arterial compliance in normal individuals and of the response to the ARB olmesartan. Measurement of PRA may help to predict clinical ARB responses in individual subjects.
Randomised study of ezetimibe, start doses of original statins, and their combination in patients with coronary heart disease and hyperlipidemia Part 2. Therapy effects on the levels of C-reactive protein and proinflammatory cytokines
Authors: Susekov A. V. , Zubareva M. Yu. , Rozhkova T. A. , Masenko V. P.
Published: October 2019

Aim. To assess the effects of original statins as monotherapy or in combination with ezetimibe on the levels of proinflammatory cytokines and high-sensitive C-reactive protein (hsCRP) in patients with coronary heart disease (CHD) and hyperlipidemia (HLP). Material and methods. The study included 60 male and female patients with CHD, primary polygenic HLP, and the levels of low-density lipoprotein cholesterol (LDL-CH) of 2,9-4,9 mmol/l. Monotherapy with original statins or ezetimibe lasted for 6 months, while the combination therapy lasted for 3 months. In all randomised patients, the levels of hsCRP, interleukin 6 (IL-6), and monocyte chemotactic protein-1 (MCP-1) were measured at baseline, 12 and 24 weeks after the therapy started. Results. At baseline, median hsCRP levels in the groups of Ezetrol, Zocor, Liprimar, and Crestor monotherapy were 0,5-0,88 mg/l, with no significant dynamics after 3 months of the treatment. Baseline IL-6 levels across the monotherapy groups were 1,94-2,54 pg/ml; at 3 months, there was a non-significant reduction by 7-32 %. After 3 months of the therapy, the decrease in MCP-1 levels was not statistically significant (-1,3-7,7 %). The combined therapy did not result in a significant dynamics of hsCRP concentrations, with the exception of the group receiving Ezetrol and Liprimar. Although the combined therapy further reduced MCP-1 levels (by 30-78 pg/ml), these changes were not statistically significant. No significant difference was observed across statin and Ezetrol groups in terms of their effects on IL-6 and MCP-1 levels. Conclusion. The comparison of the three treatment schemes demonstrated similar, but not statistically significant reduction on the levels of hsCRP, IL-6, and MCP-1. No marked benefits were observed for either monotherapy or combination therapy over 12-24 weeks of the follow-up.
Pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failure
Authors: Donetskaya O. P. , Tulupova V. A. , Shuldeshova N. V. , Fedorova M. M.
Published: October 2019

Aim. To study the role of plasma redox potential reduction in the development of endothelial dysfunction (ED) among patients with chronic heart failure (CHF) and to investigate the potential of its pharmacological correction. Material and methods. This randomised cohort study included 73 patients with CHF, due to coronary heart disease (CHD) and arterial hypertension. Mean age of the participants was 59,2±5,9 years. Functional Class (FC) I CHF was registered in 9 patients, FC II CHF in 21, FC III CHF in 23, and FC IV CHF in 11. After the baseline examination, all participants were randomised into two groups. The main group (MG) received standard therapy plus adenocin (2 ampoules in 70 ml 5% glucose, intravenously) for 10 days. Results. For the first time, the dynamics of redox potential and total pyridine nucleotide levels was assessed in relation to the FC of ischemic CHF. Redox potential reduction preceded the changes in the total pyridine nucleotide levels. In contrast to standard therapy, adenocin increased plasma redox potential and endothelial growth factor levels, while reducing endothelin-1 concentrations and NADPH oxidase activity. Conclusion. Combination therapy with adenocin – a unique medication of reduced NAD form, cardiac glycoside, and inosine, in contrast to standard treatment, significantly increased cellular redox potential in CHF, which could play an important role in angiogenesis stimulation and reverse endothelial remodelling.
Mildronate in cardiology practice – current evidence, ongoing research, and future perspectives
Authors: Mikhin V. P. , Pozdnyakov Yu. M. , Khlebodarov F. E. , Koltsova O. N.
Published: October 2019

The review discusses the benefits and various practical aspects of the new cardioprotector mildronate use in cardiology. The latest evidence on the mildronate role in complex therapy of patients with stable angina, or patients in the rehabilitation period after myocardial infarction, is summarised.
Blood pressure control in primary care patients with arterial hypertension: analysing the Hypertension Register data
Authors: Posnenkova O. M. , Kiselev A. P. , Gridnev V. I. , Schwartz V. A. , Dovgalevskyi P. Ya. , Oshchepkova E. V.
Published: October 2019

Aim. (1) To investigate clinical characteristics of primary care patients with arterial hypertension (AH), according to the achievement of target blood pressure (BP) levels; (2) to assess the effectiveness of therapeutic measures aimed at achieving target BP and maintaining its long-term control. Material and methods. This retrospective analysis included the data from ambulatory medical records of 5558 AH patients, who attended primary care centres in 2007. Clinical characteristics were compared in patients with achieved vs. non-achieved target BP levels. According to the national AH guidelines (2004), the completeness of examination, pharmaceutical therapy tactics, and frequency of the follow-up were assessed in both groups. Results. Based on the 2007 data, target BP levels were maintained in 28% of AH patients. Mean BP level was 144/87 mm Hg. Patients with optimal BP levels, compared to their peers with inadequate BP control, had significantly (p<0,001) higher prevalence of angina pectoris (40,4% vs. 30,1%, respectively) or previous myocardial infarction (19,4% vs. 8,4%), as well as higher frequency of lipid profile assessment, creatinine measurement, and echocardiography. Mean number of prescribed antihypertensive medications was 2,08 vs. 1,60, respectively. Mean number of clinical visits per year was 4,07 vs. 2,99, while mean interval between the visits reached 72,3 vs. 62,7 days, respectively. Regardless of the target BP achievement, the quality of diagnostic and therapeutic management did not comply with the recommended standards. Conclusion. Patients with optimal BP control were characterised by a more severe clinical course, as well as by a wider scope and higher frequency of diagnostic and therapeutic procedures. At the primary care level, the quality of AH diagnostics and treatment did not comply with the recommended standards; therefore, mean BP levels in the AH Register sample were higher than the target ones.
Subclinical atherosclerosis as a risk factor of cardiovascular events
Authors: Boytsov S. A. , Kukharchuk V. V. , Karpov Yu. A. , Sergienko I. V. , Drapkina O. M. , Semenova A. E. , Urazalina S. Zh.
Published: October 2019

Subclinical atherosclerosis is an initial, latent stage of chronic progressing arterial inflammation. Destabilisation of asymptomatic, hemodynamically non-significant atherosclerotic plaques (AP) could lead to myocardial infarction, stroke, or sudden death. Since the assessment of AP stability is problematic in real-world clinical settings, the risk stratification should, at least, account for the presence of subclinical atherosclerosis. In 600 ambulatory patients from the Moscow City Western Administrative Okrug who had low and moderate SCORE-assessed cardiovascular risk levels, the prevalence of AP, based on the duplex carotid ultrasound results, was 59% (n=358). Presently, no standard guidelines exist on cardiovascular risk stratification which would include the assessment of subclinical atherosclerosis, despite the importance of the latter as a prognostic factor. Large clinical studies on prognosis in patients with subclinical atherosclerosis will clarify the role of this parameter as an independent cardiovascular risk factor and facilitate the development of respective clinical recommendations.
Comparative effectiveness of the approaches to correct vascular structural and functional disturbances in postmenopausal women
Authors: Tolstov S. N. , Mychka V. B. , Salov I. A. , Prokhorova Yu. V. , Vyshivanyuk V. A.
Published: October 2019

Aim.To compare the effects of Mildronate and hormone replacement therapy (HRT) with estradiol (1 mg) and drospirenone, DSPR (2 mg) on circadian blood pressure (BP) profile, arterial structure and function, and vascular stiffness parameters in women with early postmenopause and climacteric syndrome (CS).Material and methods.The study included 94 women with early postmenopause and CS, who provided written informed consent to participate and were divided into two groups. Group I included 36 women receiving Mildronate (500 mg twice a day), while Group II included 28 women who were administered, according to clinical indications, HRT (1 mg 17β-estradiol and 2 mg DRSP once a day). The control group (CG) included 30 women who did not receive either Mildronate or DRSP. At baseline and 16 weeks later, all participants underwent the assessment of blood biochemistry; intima-media thickness (IMT) of common carotid artery (CCA); endothelium-dependent vasodilatation (EDVD) of brachial artery (BA); antithrombogenic activity of vascular wall; aortal pulse wave velocity (aPWV); arterial stiffness; and 24-hour BP monitoring (BPM).Results.The study demonstrated positive effects of Mildronate therapy and HRT (1 mg 17β-estradiol and 2 mg DRSP) on metabolic status, circadian dynamics and variability (Var) of BP, and arterial structure and function. The largest positive changes in blood lipid profile were observed in Group I and II patients. By the end of the study, these patients demonstrated significantly decreased levels of systolic and diastolic BP and reduced BP Var, particularly in Group II. Mildronate therapy, but not HRT, was associated with normalisation of vascular wall antiaggregant potential. Group II demonstrated a significant reduction in CCA IMT levels, with a similar tendency in Group I. In both groups, the degree of endothelial dysfunction (ED) decreased, which was manifested in increased BA EDVD, decreased aPWV, and reduced arterial stiffness and was more pronounced in Group II.Conclusion.In menopausal women with CS, the effects of Mildronate and HRT on metabolic, structural, and functional disturbances were similar. Therefore, Mildronate therapy could be a new method of correction of these systemic disturbances.
Sudden cardiac death and antipsychotic medications: literature review
Authors: Volkov V. P.
Published: October 2019

The review summarises the evidence from international publications on sudden cardiac death (SCD) in psychiatric patients receiving neuroleptics. Modern SCD definitions are presented, together with the relevant epidemiological data. The pathogenesis of fatal cardiac arrhythmias, caused by cardiotoxic effects of antipsychotic medications, is discussed. Electrocardiographic changes, in particular QT interval changes, as well as risk factors of SCD and main principles of its prevention, are described in detail.
Oxidative stress, its role in the pathogenesis of chronic heart failure, and potential methods of correction
Authors: Palatkina L. O. , Korneeva O. N. , Drapkina O. M.
Published: October 2019

For many years, cardiovascular disease (CVD) remains the leading cause of death worldwide. According to the World Health Organization estimates, CVD accounts for 57% of all-cause mortality in Russia. Recently, research efforts have been concentrated on the search for new CVD markers which can improve the diagnostics and treatment of this large disease group, associated with poor prognosis. The markers of oxidative stress (OS) and antioxidant enzyme activity have been considered as potential pathogenetic mechanisms in the CVD development. The potential of statins, as medications with a wide range of pleiotropic – in particular, antioxidant – effects, for the effective management of chronic heart failure (CHF) has been extensively investigated. There is an ongoing discussion whether statins could be used for the treatment of nonischemic CHF.
ECG DISPERSION MAPPING PARAMETERS DURING THE TREADMILL TEST IN PATIENTS WITH CORONARY HEART DISEASE
Authors: Ivanov G. G. , Agafoshina E. V. , Pecherskikh A. A. , Khalabi G.
Published: October 2019

Aim. The aim of the study was the complex analysis of the ECG-12 and ECG dispersion mapping (DM) parameters during the physical stress test in patients with coronary heart disease (CHD).

Material and methods. The main group included 143 CHD patients with Functional Class I–III angina (99 men and 44 women; mean age 50,6±4,6 years). The control group included 37 healthy individuals (mean age 44,3±4,8 years). Patients with heart failure signs and symptoms were excluded. All participants underwent the graduated physical stress test.

Results. Two variants of the ECG changes were observed, with normal and abnormal reaction of ECG DM parameters. The latter group was characterised by the following: ratio of heart rate and myocardial micro-alternation index (HRmax/MMImax) 30% at the peak HR.

Conclusion. Using the ECG DM method during the treadmill test is a feasible and useful approach to gain additional diagnostic information on the myocardial electro-physiological status and, therefore, to select the patients who need further examination and treatment.
Performance enhancement of asphalt patch repair with innovative heating strategy
Authors: Byzyka Juliana , Rahman Mujib , Chamberlain Denis Albert , Malieva Marina
Published: October 2019

The advantage of controlled preheating of an excavated asphalt surface prior to hot-mix asphalt patch repair, referred to as ‘dynamic repair’, is presented in this paper. The heating effects are compared with traditional repair, referred to as ‘static repair’. Shear bond and immersion wheel tracking tests were performed to assess the quality of both types of repair. Pothole excavations were created in the laboratory environment. For the static repairs, a tack coat was applied at the interfaces of the excavation prior to laying the hot repair material. For the dynamic repairs, infrared heat was applied in heating–cooling cycles prior to filling the excavation with hot-mix material, without the use of a tack coat. Heat was applied using an experimental infrared heater set at 6·6 kW with a 230 mm offset from the excavation. The results showed that the shear strength at the bottom and vertical interfaces of the dynamic repairs was, respectively, 78·2% and 68·4% higher than that of the static repairs. The immersion wheel tracking test showed that the resistance to water-related damage of the dynamic repairs was higher than that of the static repairs. It is concluded that preheating a pothole excavation with infrared heat prior to filling and compaction increases the repair interface bonding strength and durability.
Assessment of blood loss in total knee arthroplasty depending on the type of the endoprosthesis
Authors: Abelevich A. I , Abelevich O. M , Marochkov A. V
Published: October 2019

Introduction. In the modern conditions arthroplasty of joints has become one of the main methods of treatment that enables to restore joint movements, weight bearing ability and quickly return the patient to an active lifestyle. Total knee arthroplasty (TKA) is accompanied by a significant blood loss resulting in a decrease of hemoglobin level and higher requirements in postoperative blood transfusion. Purpose of the study: to estimate the volume of blood loss in patients after total knee arthroplasty depending on the design of the endoprosthesis. Patients and methods. Retrospective study included 73 patients with stage 3 gonarthrosis by Kosinskaya. All patients were divided into groups: in group 1 (n=50) the standard total cemented knee joint endoprosthesis; in group 2 (n=23) - the associated rotational constructions were used. Hemoglobin and hematocrit tests were performed prior to and in 24 hours after operation. The volume of intra- and postoperative (in 24 hours) blood loss was calculated by the of hemoglobin balance formula. Results. In 24 hours after operation the hemoglobin level was 122.5 ± 9.6 g/l in patients from group 1 and 105.1±8.2 g/l (p=0.001) in patients from group 2. The difference in hemoglobin levels in patients within group 1 was 10.5±6.6 g/l, within group 2 - 28.5±7.5 g/l (p=0.006). The volume of intra- and postoperative (in 24 hours) blood loss for the 1st and 2nd patient groups of made up 420.5±276.7 ml, in group 2 it was 1163.0±302.5 ml (p
Dispensing agar into multiwell plates July 2019 updates v1
Authors: Barlow Ida
Published: October 2019

Protocol for pouring agar into 96 well plates using Integra VIAFILL dispenser. Agar should be prepared in advance, and kept in 60oC waterbath until ready to dispense, and whilst dispensing. The X, Y, Z positions for dispensing can be adjusted according to the multiwell plates being used.
The efficacy of 4Cs-based reading to foster 21st-century learning competencies
Authors: Imamyartha David , Fitriyah Siti Masrifatul , Tasnim Zakiyah , Puspa Areta , Fardhani Aan Erlyana , Wahjuningsih Eka , Sundari Siti , Hudori Rizki Febri , Arya Bambang
Published: October 2019

The omnipresence of 4Cs at tertiary education has shifted the attention of language classroom teachings toward the mastery of multifaceted intelligences. Resultant teaching praxis subsequently calls forth students’ high literacy, which affects the nature and extent of success and failure. This study strived to scrutinize how the 4Cs approach in Reading courses scaffolds students’ multidimensional 21st-century learning competencies. Data were collected through online survey and focus group discussion, with deductive and inductive content analysis subsequently operative. The findings have shed lights on how 4Cs-based reading instructions help teachers to create learning environment commensurate with the demand of 21st-century learning, which aids students’ learning in gaining metacognitive tools for high literacy. With clear framework of collaborative work and scaffolding, teachers can trigger and further direct students’ achievement goals and social goals towards high literacy.
Ortaöğretime Geçiş Sistemi İle İlgili 2000 - 2018 Yılları Arasında Çalışılmış Lisansüstü Tez ve Makalelerin İncelenmesi
Authors: TAŞKIN Gökhan , AKSOY Gökhan
Published: October 2019

Bu çalışmanın
amacı, Ortaöğretime Geçiş Sistemi (OGS) ile ilgili 2000-2018 yılları arasında
yayımlanan lisansüstü tezleri ve makaleleri inceleyerek, ortaöğretime geçiş
sistemleri alanındaki araştırmaların belirli kategorilerdeki eğilimlerini
güvenilir ve objektif bir şekilde ortaya koymak ve oluşturulan veriler
doğrultusunda senteze dayalı bir sonuç oluşturarak değerlendirme yapmaktır.
Bu amaçla ortaöğretime geçiş sistemleriyle ilgili araştırmaların yayınlanma
tarihleri, yazarların sayısı, evreni, örneklem türü, anabilim dalı, hedef
kitlesi, yöntemleri, veri toplama araçları, veri analizi teknikleri, konu
alanları, yayımlandıkları dergi alanları açısından değerlendirilmiştir.
Çalışma yöntemi nitel araştırma yöntem türlerinden doküman incelemesidir.
Konuyla ilgili 2000 ve 2018 yılları arasında yayınlanan çalışmaların
sınırlılığını Yükseköğretim Kurulu Ulusal Tez Merkezi’nde taranan lisansüstü
tezler ile ULAKBİM ve Google Akademikte taranan
dergilerde yayımlanan özgün makaleler oluşturmaktadır. Araştırmada toplam 53
yüksek lisans - doktora tezi ve 85 özgün makale analiz edilmiştir. Verilerden
elde edilen sonuçlara göre; OGS ile ilgili yapılan çalışmalarda en fazla iki
yazarlı çalışmalar yapılmıştır. Bu çalışmaların daha çok ULAKBİM’de
indekslenen dergilerde makale olarak yayımlandığı, lisansüstü tez
çalışmalarının ise daha çok yüksek lisans tezlerinde yoğunlaştığı
görülmüştür. Veri analiz tekniği olarak en fazla içerik analizini tercih
edilmiştir, Çalışmalar en fazla eğitim bilimleri anabilim dalında yapılmıştır,
Çalışmaların en çok ortaöğretime geçiş sistemleri içerisinde Seviye Belirleme
Sınavı (SBS) sistemiyle ilgili olduğu tespit edilmiştir. Çalışmalarda yöntem
olarak daha çok tarama modelleri tercih edilmiştir.
Health Disparities in Jail Populations: Mixed Methods and Multi-Disciplinary Community Engagement for Justice and Health Impacts
Authors: Trotter Robert T. , Fofanov Viacheslav Y. , Camplain Ricky , Arazan Christine L. , Camplain Carolyn , Eaves Emery R. , Hanabury Mary , Hepp Crystal M. , Kohlbeck Bailey S. , Lininger Monica R. , Peoples Marie , Dmitrieva Natalia O. , Baldwin Julie A.
Published: October 2019

This special issue of Practicing Anthropology presents multi-disciplinary and multisectoral views of a community engaged health disparities project titled “Health Disparities in Jail Populations: Converging Epidemics of Infectious Disease, Chronic Illness, Behavioral Health, and Substance Abuse.” The overall project incorporated traditional anthropological mixed-methods approaches with theory and methods from informatics, epidemiology, genomics, evolutionary and computational biology, community engagement, and applied/translational science.
Lost to Found: The Creation of a Master's Thesis
Authors: Kohlbeck Bailey S.
Published: October 2019

The world of anthropology is vast, with endless topics to explore, and it can be challenging to find a niche. This article explores how volunteering for a unique research project in a local jail helped a new anthropologist navigate the world of anthropology and develop a master's thesis. In addition, the article will examine the unique experience of conducting research in the criminal justice system and the impact anthropology can have in different sections of the criminal justice system.
Social identity and value orientations of adoptive parents with different numbers of children
Authors: Aldasheva A.A. , Zelenova M.E. , Sivash O.N.
Published: October 2019

The article is devoted to the study of social identity and value orientation characteristics of professional adoptive parents. The results of the empirical study have demonstrated a positive correlation between the number of orphans adopted into a family, the structure of a positive social identity and value orientations of adoptive parents. The study has established that with an increase in the number of children in a family there is a tendency towards social marginality, lowered structuredness and coherence of adoptive parents’ social identity, difficulties in identifying benchmark social groups. It has been shown that in their identification process the adoptive parents with many adopted children are more likely to choose a group based on the criteria related to their profession and to a lesser extent opt for their immediate social network groups. The study has established that the hierarchy of values of adoptive parents with many adopted children significantly differs from the values profile of adoptive parents with one or two adopted children.
The 2-nd Traffic and Transport Psychology Symposium
Authors: Kochetova T.V.
Published: October 2019

This publication is a summary of the 2-nd Traffic and Transport Psychology Symposium in Nottingham, Great Britain, April 11—12, 2019. During the Symposium, the XVII Traffic Psychology International meeting took place. This report contains the main ideas of the presentations and messages of the participants of the Symposium.
Осознание возможности самотворчества в Античности: школа Пифагора
Authors: Горелов Анатолий Алексеевич , Горелова Татьяна Анатольевна
Published: October 2019

В статье анализируется смысл понятия «самотворчество» и дается разграничение между близкими понятиями «творчество», «самосовершенствование», «творчество жизни», «культура себя» и «самоактуализация». Самотворчество понимается как особая разновидность творчества, относящегося к самому творцу, который пытается изменить себя в соответствии со своими представлениями об идеале. В творчестве как природной способности человека заложен и момент самотворчества.

Первые сознательные установки самотвочества зарождаются в осевое время в философии, а систематическую методологию изменения поведения человека на ее основе находим в знаменитой в Античности школе Пифагора. Здесь была создана особая система воспитания, позволяющая выявить потенциал человека и помочь ему в достижении момента самораскрытия. Учение Пифагора закладывает общие основания концепции самотворчества.
Ensembles of ETAS Models Provide Optimal Operational Earthquake Forecasting During Swarms: Insights from the 2015 San Ramon, California Swarm
Authors: Llenos Andrea L. , Michael Andrew J.
Published: October 2019

Earthquake swarms, typically modeled as time‐varying changes in background seismicity, which are driven by external processes such as fluid flow or aseismic creep, present challenges for operational earthquake forecasting. Although the time decay of aftershock sequences can be estimated with the modified Omori law, it is difficult to forecast the temporal behavior of seismicity rates during a swarm. To explore these issues, we apply the epidemic‐type aftershock sequence (ETAS) model (Ogata, 1988) to the 2015 San Ramon, California swarm, which lasted several weeks and had almost 100 2≤M≤3.6 earthquakes. We develop three‐day forecasts during the swarm based on an ETAS model fit to all prior seismicity in the region as well as an ETAS model fit only to previous swarms in the region, which is better at capturing the higher background rate during the swarm. We also explore forecasts in which the background rate is updated periodically during the swarm using data over different lookback windows and find generally these models perform better than the models in which the background rate is fixed. Finally, we construct ensemble forecasts by combining the different models weighted according to their performance. The ensemble forecasts outperform all of the individual models and allow us to avoid making arbitrary choices at the outset of a swarm as to which single model will perform the best.
The Future of Australia’s NBN Continued
Authors: JTDE Copyeditor
Published: October 2019

TelSoc has held its first forum on the future of Australia’s National Broadband Network (NBN). Three papers from that forum are published in this issue. TelSoc is planning a second forum, discussing the user potential of the NBN, in October 2019. The historical reprint in this issue is also NBN-related about online learning. The technical papers in this issue concern architectural issues in the Internet of Things and cybersecurity. The Journal welcomes further contributions on telecommunications and the digital economy.
A study to assess the echocardiographic changes among chronic liver disease in a tertiary care center
Authors: Venu Aradya H. , Muralidhar Col
Published: October 2019

Background: Cirrhosis is associated with numerous cardiac abnormalities; however scanty information is available about the changes associated with it in Indian diaspora. which include increased cardiac output, left ventricular diastolic dysfunction, increased wall thickness of cardiac chambers, and pulmonary arterial hypertension. These concomitant cardiac abnormalities in patients with cirrhosis have been termed as ‘Cirrhotic Cardiomyopathy’. Objective of this study assess the Echocardiographic Changes among Chronic Liver disease in a tertiary care center. Method: Thirty patients with cirrhosis (alcoholic and non-alcoholic) were enrolled for the study at Department of Gastroenterology, Command Hospital, Air force, Bangalore from October 2007 to June 2009. Thirty age and sex matched controls without cardiovascular disease were included for comparison. Data collection was done by clinical history, examination and investigations. All subjects underwent Echocardiographic study was at 6 and 12 months and controls at the start of study.Results: Mean age of the study population was 54.5±15 yrs, males constituted 93% of the study population. Majority of the patients were in Child class B (43.3%) and Child A (40%). Interventricular septal thickness showed significant change compared to Control. There was no evidence of systolic dysfunction noted in the study population. There was no correlation between severity of cirrhosis and echocardiographic Changes.Conclusion: This study demonstrates that Indian patients with cirrhosis do have diastolic dysfunction. In the absence of other risk factors for cardiac disease, this dysfunction can be attributed only to cirrhotic cardiomyopathy. There is no correlation of cardiac status with severity of liver dysfunction.
“La Filosofía de la ciencia puede aportar en políticas educativas, de ciencia y tecnología, y en la difusión y socialización del conocimiento científico”
Authors: Soriano W. Alejandra
Published: October 2019

El escritor y científico Charles Percy Snow en una famosa conferencia de 1959 hablaba de las Ciencias básicas y las Humanidades como dos culturas entre las que existía un “abismo de incomprensión mutua”. A 60 años de esa reflexión, la maestría en Filosofía de la ciencia de la Universidad El Bosque parecería responder a esa “desconexión”.
In Absentia: de la realidad fragmentaria a la ficción ineludible en la novela Mañana en la batalla piensa en mí de Javier Marías
Authors: Cuéllar Danny
Published: October 2019

¿Qué peso puede tener lo ausente, lo que ya no está? ¿Cuál es la gravedad de proyectar imágenes hipotéticas a partir de la agencia potencial de quien vislumbra el futuro inasible? ¿Puede emerger la pesadumbre de la imposibilidad para comprender el todo? La novela Mañana en la batalla piensa en mí (1994), del español Javier Marías, representa las contradicciones de vivir, y comprender, los efectos de lo ausente, un singular estado que se ‘materializa’ en el recuerdo, la huella o la ilusión…