bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating Machine Learning Models for Predicting Prostate Cancer Progression Using Lifestyle Factors: A Systematic Review and Meta-Analysis
Authors: Onuiri Ernest E. , Adeniyi Oluwabamise J.
Published: September 2024

This systematic review and meta-analysis evaluated the performance of machine learning models in predicting prostate cancer progression using lifestyle factors as predictive biomarkers to improve prognostic accuracy. Various models were analyzed, including Support Vector Machine (SVM), Logistic Regression (LR), Random Forest (RF), Multi-Layer Perceptron (MLP), and Convolutional Neural Networks (CNN). These models were applied to identify diagnostic and prognostic biomarkers and to enhance the forecasting of prostate cancer progression. The meta-analysis demonstrated high predictive effectiveness across models, with mean performance metrics of 0.901 AUC (Area Under the Curve), 0.914 F1 Score, 0.889 accuracy, and 0.914 sensitivity. Among the models, the Multi-Layer Perceptron (MLP) emerged as the most effective, achieving 97% accuracy and an AUC of 95.8%. These findings underscore the potential of machine learning to integrate lifestyle factors as predictive biomarkers, advancing precision oncology in prostate cancer care.
RÈN LUYỆN PHƯƠNG PHÁP ỨNG DỤNG TOÁN XÁC SUẤT VÀO GIẢI NHANH MỘT SỐ DẠNG BÀI TẬP DI TRUYỀN NGƯỜI CHO SINH VIÊN NGÀNH SƯ PHẠM SINH HỌC
Authors: Lê Văn Trọng , Lê Thị Huyền , Hà Thị Phương , Hà Thị Hương
Published: September 2024

Trong giảng dạy sinh học, việc phân tích mối quan hệ giữa sinh học và toán học nhằm xác định các phép toán phù hợp để vận dụng giải bài tập sinh học có vai trò rất quan trọng. Bài viết giới thiệu phương pháp sử dụng lý thuyết về xác suất để giải một số dạng bài tập di truyền cho sinh viên đại học ngành sư phạm sinh học giúp sinh viên có thể giải nhanh và chính xác nhất nhiều dạng bài tập có liên quan đến di truyền người.Từ khoá: Bài tập, di truyền người, xác suất.
The Effects of Music on Performance in Human Hand-Eye Coordination
Authors: Zhou Ethan
Published: September 2024

In this paper, the effect of music on hand-eye coordination is studied. The intricacies of the complex system that enables hand-eye coordination is discussed, the possible effects of music analyzed, and an original experiment was conducted. In the experiment, participants listened to multiple genres of music while completing a task requiring hand-eye coordination and recording four statistics per trial per task. This task involved the repetition of the user positioning their cursor and clicking with the correct timing in order to achieve the highest score possible, which would be computed after the timer was over. There were limitations to the experimentation that may have resulted in inconclusive data, but the available data was still analyzed for any possible results. After processing the data, the results indicated that music did not have a significant impact on the participant’s hand-eye coordination for the overall group, but individually, certain participants did significantly perform better with select genres.
Managing Fatigue at Work: Strategies for Preserving Your Energy
Authors: Westover Jonathan
Published: September 2024

Abstract: This article examines the widespread myth that endless work is virtuous by exploring the causes and costs of workplace fatigue. It draws on research that links overwork, lack of recovery time, poor self-care, and unbalanced workloads to burnout. Specific drivers of fatigue discussed include workload issues, insufficient breaks and off-hours, lack of control, unclear priorities, and individual traits. Recommendations are provided for organizations to manage workloads sustainably, support recovery, and foster a culture of well-being. Implementation examples focus on healthcare, technology, and education sectors, such as limiting overtime alerts, rotating flexible schedules, and allocating passion project time. The conclusion argues that respecting human energy limits, enabling recharging periods, and caring for employee wellness leads to higher performance and engagement over the long run compared to outdated models glorifying overwork.
Studi Demokrasi Lokal: Tinjuan Literatur Sistematis (SLR)
Authors: Fahmi Widianto
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pelaksanaan demokrasi lokal serta partisipasi masyarakat terhadap demokrasi lokal. Metode penelitian yang diterapkan pada penelitian ini adalah systematic literature review yang menggunakan 450 artikel ilmiah. Artikel-artikel ini berasal dari jurnal internasional dan dijadikan sebagai sumber data utama penelitian ini yang bersumber dari databse scopus. Review artikel menggunakan aplikasi Vosviewer. Hasil penelitian mengungkapkan bahwa trend penelitian demokrasi lokal saat dari tahun 2021-2024 mengalami penurunan. Penelitian tentang demokrasi lokal merupakan salah satu topik yang menarik banyak perhatian ahli dan telah menjadi subjek diskusi yang luas. Hal ini didukung oleh sejumlah penelitian yang menyoroti ketimpangan yang masih terjadi seperti konflik masyarakat dan pemerintah, kurangnya partisipasi masyarakat, dan ketidakmurnian demokrasi. Mengingat pertimbangan-pertimbangan ini, penting untuk memahami perkembangan penelitian atau karya ilmiah yang berkaitan dengan demokrasi lokal. Penelitian ini memiliki signifikansi yang besar untuk memandu arah masa depan maka penting untuk mengetahui bagaimana perkembangan penelitian. Analisis dilakukan terhadap berbagai aspek fundamental terkait konsep, dampak, dan makna demokrasi lokal yang telah dikaji sebelumnya. Keterbatasan penelitian ini adalah artikel yang digunakan hanya bersumber dari database scopus sehingga temuan penelitian tidak dapat menggambarkan secara komprehensif tentang demokrasi lokal di berbagai dunia.
PERWUJUDAN GOOD GOVERNANCE SEBAGAI STRATEGI PENEGAKAN HUKUM DALAM UPAYA MENGURANGI TINGKAT KECELAKAAN LALU LINTAS DAN MENINGKATKAN KETERTIBAN HUKUM MASYARAKAT
Authors: M. Shohibul Jamil
Published: September 2024

Data kecelakaan dan pelanggaran lalu lintas yang dihimpun oleh Ditlantas Babinkum Polda Jateng memberikan gambaran bahwa tingkat kecelakaan lalu lintas dan tingkat ketertiban masyarakat terhadap hukum lalu lintas sangat memprihatinkan, hal ini apabila tidak dilakukan langkah strategis guna mengurangi tingkat kecelakaan lalu lintas dan meningkatkan ketertiban hukum masyarakat maka akan menimbulkan kerugian yang sangat besar, bukan saja korban jiwa dan harta namun juga akan menimbulkan kerugian dibidang ekonomi. Tujuan penelitian ini adalah untuk mengetahui kebijakan-kebijakan yang sudah dilakukan Polri guna mewujudkan good governance, untuk mengetahui kinerja
Polri dalam upaya mengurangi tingkat kecelakaan lalu lintas dan meningkatkan ketertiban hukum masyarakat serta untuk mengetahui konsep strategisnya. Penelitian ini bersifat analitis deskriptif jika dilihat dari tujuannya termasuk penelitian hukum yuridis empiris. Lokasi penelitian ini dilakukan di Satlantas Polda Jateng, dan masyarakat pengguna jalan . Jenis data yang digunakan meliputi data primer dan data sekunder.Teknik pengumpulan data melalui wawancara dan penelitian kepustakaan baik buku-buku, peraturan perundang-undangan, hasil
penelitian terdahulu. Analisis data menggunakan analisis kualitatif. Berdasarkan penelitian ini, diperoleh hasil bahwa kecelakaan lalu lintas di
Indonesia dapat digambarkan dalam data kurun waktu 2 tahun terakhir menunjukkan bahwa kecelakaan lalulintas yang terjadi di Indonesia telah merenggut korban jiwa rata-rata 10.000 per tahun. Penyebab kecelakaan yang terjadi didominasi oleh faktor manusia, kendaraan, faktor jalan, dan factor lingkungan. Maka untuk tujuan menciptakan masyarakat tertib hukum guna mewujudkan Kamseltibcar Lantas dibutuhkan suatu strategi yaitu dengan melaksanakan prinsip-prinsip good governance yakni: partisipasi, transparansi, akuntabilitas, efektif dan efisien, penegakan hukum, responsif, konsensus,setara dan inklusif, yang kemudian strategi-strategi ini telah diejawentahkan ke dalam program-program jangka pendek, jangka menengah, dan jangka panjang. Program-program tersebut mengandung strategi tentang pendidikan masyarakat, tentang lalu lintas jalan dan peraturan lalu lintas, pemahaman terhadap visi dan misi penegak hukum di bidang lalu lintas, peningkatan kualitas aparat hukum di bidang lalu lintas, peningkatan sarana dan prasarana, mendayagunakan teknologi, manajemen dan rekayasa lalu lintas.
Pengaruh Sistem Akuntansi dan Kompetensi Akuntansi Terhadap Potensi Penyalahgunaan Dana Desa (Studi Kasus Di Kabupaten Demak)
Authors: Husnurrosyidah  , Ginanjar Suendro
Published: September 2024

The potential for misuse of the funds of the village in Indonesia has increased due to misconstrued one side, basic education is the head of the village and its officials not derived from competencies of accounting. The village chief has the desire and the hope that created a computerized accounting system to simplify financial reporting the village Fund. Thus, a good Accounting System in conducting employee administration finance village Fund will be able to reduce the potential for abuse of the village Fund.This research aims to know the influence of the accounting system and accounting competency against the potential misuse of funds. This research is the research field (field research) with a quantitative approach. The data used are the primary data with survey methods through the dissemination of the questionnaire. There are two independent variables in this study i.e. (X 1) accounting systems and accounting competency (x 2). The dependent variable (Y) village Fund abuse. The technique of sampling using random sampling so that the retrieved samples of the 101 people who represent their respective villages in Kabupaten Demak.The results showed that 1) influential accounting systems against misuse of funds i.e. village of 0762 with pvalue < 0.01; 2) influential accounting competency against the misappropriation of funds of the village i.e. of 0461 with p-value = 0.07.
PENGARUH LAYANAN DAN FASILITAS PERPUSTAKAAN TERHADAP KEPUASAN MAHASISWA PENGGUNA PERPUSTAKAAN DI STIE MAHARDHIKA SURABAYA
Authors: Atika Kumalasari  , Asmirin Noor  , Susilowati  , M. D. Kharis Rifai
Published: September 2024

Penelitian ini bertujuan untuk mengetahui: 1) pengaruh layanan perpustakaan terhadap kepuasan mahasiswa pengguna perpustakaan STIE Mahardhika Surabaya 2) pengaruh fasilitas perpustakaan terhadap kepuasan mahasiswa pengguna perpustakaan STIE Mahardhika Surabaya
3) pengaruh layanan dan fasilitas perpustakaan terhadap kepuasan mahasiswa pengguna perpustakaan STIE Mahardhika Surabaya. Penelitian ini merupakan penelitian kuantitatif. Populasi dalam penelitian ini adalah seluruh mahasiswa STIE Mahardhika yang menggunakan
jasa layanan dan fasilitas perpustakaan STIE Mahardhika Surabaya dan sampel yang digunakan sebanyak 40 mahasiswa STIE Mahardhika Surabaya pengguna perpustakaan STIE Mahardhika Surabaya. Metode analisis data yang digunakan adalah regresi linear berganda. Hasil penelitian ini menunjukkan bahwa: 1) layanan perpustakaan berpengaruh positif terhadap kepuasan mahasiswa pengguna perpustakaan STIE Mahardhika Surabaya 2) fasilitas perpustakaan berpengaruh positif terhadap kepuasan mahasiswa pengguna perpustakaan STIE Mahardhika Surabaya 3) variabel layanan dan fasilitas perpustakaan berpengaruh positif terhadap kepuasan mahasiswa pengguna perpustakaan STIE Mahardhika Surabaya.
PENERAPAN STRATEGI PEMASARAN UNTUK MENINGKATKAN PENJUALAN PRODUK 3i NETWORK DENGAN MENGGUNAKAN ANALISA SWOT (Studi Kasus Pada PT. AJ Central Asia Raya Cabang Semarang)
Authors: Ginanjar Suendro
Published: September 2024

This study discusses marketing strategies that have been approved or carried out at PT.AJ Central Asia Raya Semarang Branch in terms of selling 3i Network products to new customers or retaining old customers using qualitative descriptive research using SWOT analysis.
This research was conducted by direct interview method by distributing questionnaires. The population in this study were all employees and director agencies at PT. AJ Central Asia Raya Semarang Branch and the samples used are all employees and director agencies at PT. AJ
Central Asia Raya Semarang Branch. Data collection methods used were documentation, questionnaires / questionnaires and qualitative literature research with evidence attached in the appendix.
The results of this qualitative study indicate the strategies used by PT. AJ.Central Asia Raya Semarang by using a diversification or innovation strategy. By using the analysis of SAP and ETOP PT. AJ Central Asia Raya Semarang Branch is in a strong internal position and an external position in speculative business. So the company PT.AJ Central Asia Raya Semarang Branch is in an investment position to develop 3i Network products with increasingly aggressive innovations to increase the company's turnover.
Peran Perilaku pada Sistem Pengendalian Manajemen (Studi Kasus pada Bank di Ungaran)
Authors: Jaluanto Sunu Punjul Tyoso  , Claudia Raynera
Published: September 2024

Tujuan penelitian ini untuk mengetahui perilaku pegawai pada sistem pengendalian manajemen Bank dan hambatan perilaku pegawai dalam penerapannya. Deskriptif kualitatif sebagai metode penelitian digunakan. Metode penelitian ini adalah yaitu pengumpulan, pengolahan, penyajian dan analisis data yang berkaitan dengan aspek perilaku dalam sistem pengendalian manajemen dengan menggunakan observasi langsung di lingkungan perusahaan. Jumlah sampel untuk penelitian ini adalah 54 pegawai Bank. Hasil analisis menunjukkan bahwa sebagian besar pegawai bank sudah menunjukkan perilaku yang diharapkan oleh perusahaan dengan mengikuti SOP yang diberikan oleh perusahaan. Perilaku karyawan yang tidak sesuai dengan SOP perusahaan akan segera ditindaklanjuti oleh atasan dengan memberitahukan dan memberikan peringatan yang tidak berulang. Perilaku karyawan memanifestasikan dirinya dalam bentuk mindfulness, bekerja di perusahaan, mematuhi sistem yang ditetapkan oleh manajemen sehingga tujuan perusahaan dapat tercapai. Perilaku karyawan dapat berperan dalam sistem pengendalian manajemen, karena perilaku negatif karyawan dalam sistem pengendalian manajemen dapat merugikan baik karyawan maupun perusahaan.
Studi Analisis Kualitatif Good Corporate Governance (GCG) dalam Pencegahan Fraud pada Lembaga Keuangan BPR
Authors: R. Dionesius Anto Widiyatmoko
Published: September 2024

BPR rata-rata memiliki bentuk legal formal (bentuk usaha) perseroan terbatas (PT), dimana memiliki ciri khas yakni adanya pemisahan yang jelas dan tegas antara pemilik (prinsipal) dan pengelola/ manajemen (agen). Pemisahan antara pemilik dan pengelola tersebut, dalam praktiknya kerap menimbulkan berbagai tantangan dan dinamika terutama dalam hal tata kelola yang baik (good corporate governance), sebagai mana yang diatur dalam Peraturan Otoritas Jasa Keuangan Nomor 4/POJK.03/2015 tentang Penerapan Good Corporate Governance bagi Bank Perkreditan Rakyat. Penelitian ini mengambil contoh kasus pada sebuah BPR, yang didalamnya terindikasi terjadi berbagai tindakan fraud dengan berbagai macam skema terhadap tata kelola yang dilakukan oleh manajemen (Direktur Utama dan Komisaris Utama). Dengan mengaplikasikan metode penelitian terapan (applied research), Peneliti akan menjabarkan secara sistematis bentuk kecurangan yang dilakukan manajemen dan kelemahan sistem pengendalian internal yang ada dalam menjalankan good corporate governance. Hasil dari penelitian ini menyimpulkan bahwa peran aktif pemilik (prinsipal) pada kegiatan operasional memang tidak diperkenankan. Namun demikian pemilik memiliki peran sentral dalam hal memberikan teladan (tone at the top), sekaligus berperan aktif dalam memantau kegiatan operasional perusahaan. Keberadaan dewan komisaris dan organ pendukungnya dapat dimanfaatkan oleh pemilik guna memantau kinerja direksi. Selain itu peran aktif dan pola pikir skeptis dari dewan komisaris juga diperlukan dalam rangka mewujudkan mekansime check and balance dalam tata kelola usaha yang baik di BPR.
ANALISA SUDUT PANDANG CIVITAS AKADEMIKA TERHADAP KEAHLIAN AKUNTAN BERBASIS FORENSIK (STUDI EMPIRIS PADA CIVITAS AKADEMIKA STIE CENDEKIA KARYA UTAMA SEMARANG)
Authors: Sugiarto  , Yulia Kusumaningrum
Published: September 2024

This study aims to analyze the differences in perceptions between accounting lecturers, accounting students, and education staff regarding deductive analysis skills, critical thinking, solving unstructured problems, investigative flexibility, analytical skills, oral communication, written communication, knowledge of law, and a calm attitude. Is a relevant part of the forensic accountant’s expertise. The research objects are accounting lecturers, accounting students, and educational staff. This research is an empirical study with purposive sampling technique in data collection. Data were obtained by distributing questionnaires as many as 37 at STIE Cendekia Karya Utama Semarang consisting of 11 accountig lecturers, 16 accounting students, and 10 education staff who have provided answers. Data analysis was performed using the
Independent Sample Test with the SPSS program. The results of hypothesis testing show that there is no significant difference in perceptions
between accounting lecturers, accounting students, and education staff on flexibility skills, wtitten communication skills, ang legal knowledge. The results of hypothesis testing show that there are significant differences in perceptions between accounting lecturers, accounting students, and education staff on deductive analysis skills, critical thinking, problem solving, analytical skills, oral communication and being calm
Experiencias y barreras para el control del peso en adultos obesos: un estudio cualitativo en Moquegua, Perú
Authors: Falcón Jorge Edny , Alvarez Becerra Rina , Zevallos Delgado Blanca Raquel , Condori Yupanqui Rosa
Published: September 2024

Objetivo: Comprender las experiencias y las barreras que contribuyen con el sobrepeso u obesidad de adultos para mejorar el diseño de intervenciones efectivas y sostenibles en un hospital de ESSALUD de Ilo en Moquegua -Perú.
Material y métodos: Estudio cualitativo en el que participaron pacientes de ambos sexos con un IMC ≥30 kg/m2. A los pacientes se les ofreció entrevistas en audio. Se realizaron 10 entrevistas en profundidad semiestructurada con espacio para la exploración individual en julio 2023. Las entrevistas fueron grabadas, transcritas y analizadas mediante el enfoque temático. Se utilizó el software ATLAS TI versión 23 para gestionar los datos.
 Resultados: Surgieron tres temas: (1) razones del aumento de peso y motivaciones para disminuir el peso, (2) experiencias favorecedoras y barreras para la pérdida de peso (3) expectativas y consecuencias.
Conclusión: Los pacientes reconocieron la necesidad de modificar sus hábitos alimentarios y las consecuencias afectaron su salud física y mental. Se necesita ampliar e institucionalizar el ejercicio y la actividad física y mejorar la alfabetización sanitaria pueden prevenir y controlar a obesidad.
Parálisis aislada del tercer nervio craneal
Authors: Céspedes Hernández Luis Antonio , Lanchipa Picoaga Javier , Cáceres Cáceres Pamela de Los Milagros , Trujillo Alvarez Kenny Hilmer
Published: September 2024

El presente reporte aborda el caso de un paciente de 55 años que presentó una parálisis aislada del tercer nervio craneal. El cuadro clínico se caracterizó por dolor retroocular de moderada a severa intensidad seguido de diplopia (visión doble). Durante el examen físico se objetivó ptosis palpebral izquierda y alteración de la motilidad ocular, sin afectación pupilar. Considerando los antecedentes patológicos del paciente (diabetes mellitus e hipertensión arterial), se planteó la etiología isquémica como la más probable. Sin embargo, en el diagnóstico diferencial de este tipo de parálisis no existe un consenso claro sobre la necesidad de solicitar neuroimágenes de rutina. El objetivo del presente reporte de caso es evaluar los diagnósticos diferenciales a considerar en pacientes con esta afectación, que incluyen causas aneurismáticas, infecciosas, isquémicas, traumáticas, entre otras.
UPAYA PASTORAL KONSELING BAGI PEMUDA YANG MENGALAMI TRUST ISSUE AKIBAT KONFLIK SAAT BERPACARAN
Authors: Lanongbuka Amartya Lovelin , Luma Subaedah
Published: September 2024

Trust issue is a situation where a person becomes a person who does not easily trust other people. Trust issues can cause things that can be detrimental to the person who experiences them in the future, such as causing disappointment and missing important moments in life. Trust issues mostly arise among young people who are already dating and have a negative impact on the survival of these young people both psychologically and socially. For this reason, the aim of this research is to describe the impact of trust issues experienced by young people and pastoral counseling efforts regarding trust issues among young people.
The method used in this research is a descriptive research method, with data collection through observation and interviews with several young people in Bira Village. The results of this research show that the trust issues experienced by the subjects are fear of building new relationships, always having negative prejudices towards partners and also people around them, both friends and family, and some are afraid to get married. For this reason, pastoral counseling is a service effort that can help subjects experience positive changes and get out of their problems, and experience holistic healing.
KETELADANAN HIDUP MENURUT 1 TIMOTIUS 4:12 DAN IMPLEMENTASINYA KEPADA REMAJA DI JEMAAT GMIM SION MALALAYANG
Authors: Sege Anastasya Tesalonika , Selanno Semuel , Thomas Art Semuel
Published: September 2024

The purpose of this study is to realize the nature and responsibility and concern in understanding the existence of adolescents to instill good spiritual values for teenagers so that teenagers can also be an example for people without making age a measure. The research was conducted on teenagers in the GMIM Sion Malalayang congregation to find out how teenagers understand the exemplary life according to 1 Timothy 4: 12. The approach used in this research is to use a qualitative approach as well as by conducting interviews and observations.
Based on the results of the research that has been done, it can be said that teenagers do not understand the exemplary life according to 1 Timothy 4:12 so that the principles of exemplary life in it cannot be applied properly by teenagers. therefore teenagers should understand as well as possible the context and application of exemplary life from 1 Timothy 4:12 and of course there needs to be support from the surrounding environment such as church and parents / adults
Meningkatkan Motivasi Belajar Siswa Dalam Pendidikan Agama Kristen Melalui Strategi Pembelajaran Berbasis Masalah
Authors: Manein Adika Putri , Tengkue Anggreini Angelina , Katiandagho Liviana , Ilat Irene Preisilia
Published: September 2024

Pendidikan agama Kristen di sekolah memiliki peran penting dalam membentuk karakter dan spiritualitas siswa. Namun, seringkali motivasi belajar siswa dalam konteks ini menjadi tantangan. Artikel ini mengkaji pentingnya motivasi belajar siswa dalam pendidikan agama Kristen dan mengusulkan strategi pembelajaran berbasis masalah sebagai solusi potensial. Dengan menyelidiki strategi pembelajaran berbasis masalah yang memengaruhi motivasi belajar siswa, kami menyoroti pentingnya pendekatan yang efektif untuk meningkatkan keterlibatan siswa dalam pembelajaran agama Kristen. Strategi pembelajaran berbasis masalah diusulkan sebagai cara yang dapat merangsang minat siswa dengan memungkinkan mereka untuk memecahkan masalah dunia nyata yang relevan dengan ajaran agama Kristen. Artikel ini menawarkan pandangan mendalam tentang motivasi belajar siswa dalam pendidikan agama Kristen dan menyoroti potensi strategi pembelajaran berbasis masalah. Diharapkan artikel ini dapat memberikan kontribusi yang berarti bagi pengembangan pendidikan agama Kristen yang lebih bermakna dan efektif di masa depan.
EKONOMI PASTORAL: GAYA HIDUP KONSUMTIF DAN KEKERASAN DALAM RUMAH TANGGA
Authors: Salindeho Veibe , Dendeng Leonardo Caesar , Nani Deissy , Palar Dennis , Timomor Jenifer Makarios , Wengen Natalia Christine , Salindeho Mila Enjeli , Manambe Claudia Vain , Barangke Rosita Karalina
Published: September 2024

Abstract
The study discussed the relationship between a consumer lifestyle and domestic violence. A consumptive life-style often involves excessive spending to satisfy personal wants without considering the needs or financial balance of the home. Studies show that financial pressures from a consumer lifestyle can be a factor that triggers or aggravates domestic violence. Factors such as financial tensions, unfulfilled feelings, and money-related conflicts can increase marital tension and cause violent incidents. The research methodology used is the research methodology of service learning research aimed at connecting education with the community and its needs.
ETIKA PELAYANAN KONSELING PASTORAL PENDETA BAGI JEMAAT
Authors: Nendissa Julio Eleazer
Published: September 2024

It is important for a Pastor in his ministry as a servant of God to know his duties and calling. In thiscase, not only as a preacher but also as a counselor who builds relationships with the congregation. Asa counselor, the Pastor must practice pastoral counseling services and first understand ethical issues.The aim of this research is to describe and analyze the ethics of the Pastor's pastoral counselingservices for congregations experiencing problems in their lives. In this paper, the author uses aqualitative research method with a descriptive approach and data collection techniques using literaturein the form of journals, books, articles related to this research so that he can collect data accuratelyand precisely. Based on a review of the literature, the author finds that the ethics of pastoralcounseling services are humanitarian in nature, the role of pastoral counseling in the lives ofcongregations experiencing problems, and a Pastor must have pastoral counseling ethics in whichthere are 4 principles, namely confidentiality, responsibility, awareness of limitations as a Counselor,and knowing basic needs of the congregation. Therefore, various ethics of the Pastor's pastoralcounseling services must be practiced with the congregation so that they can feel the warmth, careand togetherness of a Pastor.
BROKEN HOME PADA REMAJA
Authors: Makagingge Revina , Veni Rompas Veni Kristin Rompas , Putri Ronoko Putri Kesia Ronoko
Published: September 2024

Broken home  dapat  disebut keluarga yang sumbang dan tidak berfungsi sebagai keluarga yang harmonis, penuh kasih sayang, dan suportif karena terdapat permasalahan dan konflik yang menyebabkan perpecahan. Anak dari keluarga yang berantakan adalah anak dari orang tua yang bercerai, dan anak dari keluarga yang tidak atau rukun. Ada banyak faktor yang menjelaskan mengapa bayi mengalami patah hati, termasuk kelalaian orang tua, perceraian, dan kebencian orang tua. Metode yang digunakan untuk mengumpulkan data dalam penelitian ini adalah metode studi literatur. Setiap data yang diperoleh merupakan hasil penelitian yang dilakukan melalui buku dan artikel terkait Broken Home. Hal terpenting yang dapat diambil dari artikel ini adalah pemahaman tentang apa yang menyebabkan rumah tangga berantakan pada perempuan, yang dapat menimbulkan konsekuensi negatif ketika perempuan mencari jati dirinya. Remaja yang seharusnya menjalani masa mudanya dengan menceritakan karena remaja adalah masa yang menyenangkan, tetapi harus diperhatikan dengan akibat Broken Home yang ada dalam keluarganya.
PENDEKATAN PASTORAL KONSELING MELALUI TRADISI E”HAKA/E’HA: STRATEGI KOMUNITAS TALAUD DALAM PENCEGAHAN PENCURIAN DAN PEMULIHAN HUBUNGAN SOSIAL
Authors: Sapoh Fani , Awalo Merri Lusia , Baraa Fony , Ratunguri Isye
Published: September 2024

The E'haka/E'ha tradition is a village rule in Talaud, North Sulawesi, dating back to 1935, to address coconut theft. For 3 months, people are prohibited from picking coconuts for commercial purposes, except for personal needs or special events. There are sanctions for violators, such as fines and public apology rituals. The implementation mechanism involves community leaders announcing the rules, a team of supervisors to monitor, and active participation from the community. Sanctions for violators include monetary fines, confession, and acts of atonement. In pastoral counseling, this tradition is used as an approach to help communities overcome conflict, restore relationships, and build solidarity. The functions of pastoral counseling include guiding in ethical decision-making, reconciliation, strengthening community solidarity, and spiritual growth. It helps maintain social harmony and prevent conflict within the community
Bullying dan Dampaknya Bagi Remaja
Authors: Tonggengbio Greity Indah , Salindeho Yuriske Fillia , Ilat Irene Preisilia
Published: September 2024

Tulisan ini membahas tentang bullying sehingga bertujuan untuk mengetahui dan menjelaskan bagaimana dampak bullying bagi remaja dilihat dari fenomena yang maraknya terjadi dalam kehidupan remaja. Di dalamnya pun juga menjelaskan bagaimana peran orang tua dan gereja dalam menanggapi kasus ini yang terjadi pada remaja, adapun tulisan ini menggunakan metode studi literatur yang berpusat pada pengumpulan data melalui buku-buku,artikel dan sumber-sumber yang relevan. Hasil dari tulisan yang dibuat ini didapati bagaimana penyebab dan dampak bullying yang terjadi serta apa peran orangtua dan gereja dalam menyikapi kasus ini.Sebagai kesimpulan dari tulisan ini Dalam konteks ini, peran orang tua dan gereja sangatlah penting dalam menanggapi kasus bullying yang terjadi pada remaja.Dengan demikian, melalui kesadaran akan penyebab dan dampak bullying serta peran penting orang tua dan gereja dalam menanggapi kasus ini, diharapkan kita dapat menciptakan lingkungan yang lebih aman dan mendukung bagi remaja.
Menanggapi Tantangan Kebersihan Lingkungan di Desa Koha Timur : Analisis Keterbatasan Akses Pembuangan Sampah dan Upaya Peningkatan Kesadaran Masyarakat
Authors: Brek Yohan , Purba , Bereheme Adyatmo , Pontonuwu Oktavianus Fidel , Kalumata Maria Injily , Tumbel Masrhanda Monica , Datunsolang Masye Vicke Shelin , Kanalung Matheos Arfan , Wenas Marcelino Edison , Tulung Elmia Rahel , Wongkar Regina Olivia , Manapode Atalia , Pontoh Alfira , Putra Taufik Pratama , Kawulur Feibyola Yoselin , Tadete Julianti Regina , Pontius Stella
Published: September 2024

The  implementation of Real Work  Lecture in East Koha Village, Mandolang District was attented by 14 students active at the Manado State Christian Institute. Whitin a period of one month, KKN students saw serious environmentak problems in East Koha  village. The accumulation of rubbish that occurred everywhere caused inconvenience to the community in preparing this article, KKN is based  on the form of community service in the preparation  of this article using descriptive analisys qualitative research methods by collecting data from observations, interviews and documentation. Seeing the existing situation, KKN students held a main program regarding environmental celanliness in East Koha  village by conducting outreach to the heads of guards regarding the importance of keeping the sorrounding environment clean. Meanwhile, KKN students also distributed emergency trash cans with waste classification at every waste accumulation point ih the hope of increasing awareness community and reduce the accumulation of waste in East Koha village.
PENGARUH PENGGEMBALAAN PRA NIKAH TERHADAP KESIAPAN EMOSIONAL DAN SPIRITUAL PASANGAN DALAM MEMASUKI PERNIKAHAN
Authors: Lumunder Epafras Mario , Retor Esther Avilita , Kreysen Inriany F. , Bawihu Sylvia Evangelin , Awalo Meri Lusia , Wolter Weol
Published: September 2024

This research explores the importance of premarital counseling and guidance programs in preparing couples to enter a harmonious and sustainable married life. The research was conducted using a literature review approach to analyze relevant literature, including books, scientific journal articles, and other relevant documents. The results show that premarital counseling programs play a crucial role in equipping couples with the necessary knowledge and skills, such as emotional readiness, effective communication skills, conflict resolution, and a deep understanding of the dynamics of marriage. The program also provides significant benefits in spiritual formation, which is important for enhancing the spiritual and emotional readiness of couples. Premarital shepherding helps couples understand the meaning and purpose of marriage according to spiritual values, improves communication and cooperation in family life, and strengthens commitment to marriage. This study emphasizes the need for adequate preparation through premarital counseling and guidance programs to reduce uncertainty and prepare couples for the challenges of married life.
Sinergitas Guru Pendidikan Agama Kristen dan Guru Bimbingan Konseling Dalam Konseling Pastoral Kepada Siswa Dari Keluarga Broken Home Di Smk PP Negeri Kalasey
Authors: Sipahutar Elizabeth Nastasya , Weol Wolter , Brek Yohan
Published: September 2024

This article aims to identify and analyze the synergy of Christian Religious Education teachers and Counseling Guidance teachers in pastoral counseling to students from broken home families at SMK PP Negeri Kalasey. This study used an analytic descriptive qualitative research approach. Data were collected through observation, interviews and documentation. From the results of data analysis and interpretation, it is obtained that Christian Religious Education teachers in teaching and providing counseling guidance to students from broken home families synergize with Counseling Guidance teachers whose role is to provide counseling guidance to these students. This is indicated by the role of Christian Religious Education teachers and Counseling Guidance teachers collaborating to conduct pastoral counseling to students from broken home families and how Christian Religious Education teachers and Counseling Guidance teachers work together to conduct pastoral counseling. So from the findings it is recommended that all parties can work together in educating and guiding students from broken home families who have problems experiencing spiritual growth and better character changes.
Robust variability of grid cell properties within individual grid modules enhances encoding of local space
Authors: Redman William T , Acosta-Mendoza Santiago , Wei Xue-Xin , Goard Michael J
Published: September 2024

Although grid cells are one of the most well-studied functional classes of neurons in the mammalian brain, whether there is a single orientation and spacing value per grid module has not been carefully tested. We analyze a recent large-scale recording of medial entorhinal cortex to characterize the presence and degree of heterogeneity of grid properties within individual modules. We find evidence for small, but robust, variability and hypothesize that this property of the grid code could enhance the encoding of local spatial information. Performing analysis on synthetic populations of grid cells, where we have complete control over the amount heterogeneity in grid properties, we demonstrate that grid property variability of a similar magnitude to the analyzed data leads to significantly decreased decoding error. This holds even when restricted to activity from a single module. Our results highlight how the heterogeneity of the neural response properties may benefit coding and opens new directions for theoretical and experimental analysis of grid cells.
Single dopaminergic neuron DAN-c1 in Drosophila larval brain mediates aversive olfactory learning through D2-like receptors
Authors: Qi Cheng , Qian Cheng , Steijvers Emma , Colvin Robert A , Lee Daewoo
Published: September 2024

The intricate relationship between the dopaminergic system and olfactory associative learning in
Drosophila
has been an intense scientific inquiry. Leveraging the formidable genetic tools, we conducted a screening of 57 dopaminergic drivers, leading to the discovery of DAN-c1 driver, uniquely targeting the single dopaminergic neuron (DAN) in each brain hemisphere. While the involvement of excitatory D1-like receptors is well-established, the role of D2-like receptors (D2Rs) remains underexplored. Our investigation reveals the expression of D2Rs in both DANs and the mushroom body (MB) of third instar larval brains. Silencing D2Rs in DAN-c1 via microRNA disrupts aversive learning, further supported by optogenetic activation of DAN-c1 during training, affirming the inhibitory role of D2R autoreceptor. Intriguingly, D2R knockdown in the MB impairs both appetitive and aversive learning. These findings elucidate the distinct contributions of D2Rs in diverse brain structures, providing novel insights into the molecular mechanisms governing associative learning in
Drosophila
larvae.
Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits
Authors: Sukumaran Rashmi , Nair Achuthsankar S , Banerjee Moinak
Published: September 2024

Burden of stroke differs by region, which could be attributed to differences in comorbid conditions and ethnicity. Genomewide variation acts as a proxy marker for ethnicity, and comorbid conditions. We present an integrated approach to understand this variation by considering prevalence and mortality rates of stroke and its comorbid risk for 204 countries from 2009 to 2019, and Genome-wide association studies (GWAS) risk variant for all these conditions. Global and regional trend analysis of rates using linear regression, correlation, and proportion analysis, signifies ethnogeographic differences. Interestingly, the comorbid conditions that act as risk drivers for stroke differed by regions, with more of metabolic risk in America and Europe, in contrast to high systolic blood pressure in Asian and African regions. GWAS risk loci of stroke and its comorbid conditions indicate distinct population stratification for each of these conditions, signifying for population-specific risk. Unique and shared genetic risk variants for stroke, and its comorbid and followed up with ethnic-specific variation can help in determining regional risk drivers for stroke. Unique ethnic-specific risk variants and their distinct patterns of linkage disequilibrium further uncover the drivers for phenotypic variation. Therefore, identifying population- and comorbidity-specific risk variants might help in defining the threshold for risk, and aid in developing population-specific prevention strategies for stroke.
Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development
Authors: Rubin Sarah , Agrawal Ankit , Seewald Anne , Lian Meng-Jia , Gottdenker Olivia , Villoutreix Paul , Baule Adrian , Stern Tomer , Zelzer Elazar
Published: September 2024

Chondrocyte columns, which are a hallmark of growth plate architecture, play a central role in bone elongation. Columns are formed by clonal expansion following rotation of the division plane, resulting in a stack of cells oriented parallel to the growth direction. In this work, we analyzed hundreds of Confetti multicolor clones in growth plates of mouse embryos using a pipeline comprising 3D imaging and algorithms for morphometric analysis. Surprisingly, analysis of the elevation angles between neighboring pairs of cells revealed that most cells did not display the typical stacking pattern associated with column formation, implying incomplete rotation of the division plane. Morphological analysis revealed that although embryonic clones were elongated, they formed clusters oriented perpendicular to the growth direction. Analysis of growth plates of postnatal mice revealed both complex columns, composed of ordered and disordered cell stacks, and small, disorganized clusters located in the outer edges. Finally, correlation between the temporal dynamics of the ratios between clusters and columns and between bone elongation and expansion suggests that clusters may promote expansion, whereas columns support elongation. Overall, our findings support the idea that modulations of division plane rotation of proliferating chondrocytes determines the formation of either clusters or columns, a multifunctional design that regulates morphogenesis throughout pre- and postnatal bone growth. Broadly, this work provides a new understanding of the cellular mechanisms underlying growth plate activity and bone elongation during development.
TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice
Authors: Wang Jing , Yin Yingying , Yang Lei , Qin Junchao , Wang Zixiang , Qiu Chunhong , Gao Yuan , Lu Gang , Gao Fei , Chen Zi-Jiang , Zhang Xiyu , Liu Hongbin , Liu Zhaojian
Published: September 2024

Transmembrane channel-like (TMC) proteins are a highly conserved ion channel family consisting of eight members (TMC1–TMC8) in mammals. TMC1/2 are components of the mechanotransduction channel in hair cells, and mutations of TMC1/2 cause deafness in humans and mice. However, the physiological roles of other TMC proteins remain largely unknown. Here, we show that Tmc7 is specifically expressed in the testis and that it is required for acrosome biogenesis during spermatogenesis. Tmc7−/− mice exhibited abnormal sperm head, disorganized mitochondrial sheaths, and reduced number of elongating spermatids, similar to human oligo-astheno-teratozoospermia. We further demonstrate that TMC7 is colocalized with GM130 at the cis-Golgi region in round spermatids. TMC7 deficiency leads to aberrant Golgi morphology and impaired fusion of Golgi-derived vesicles to the developing acrosome. Moreover, upon loss of TMC7 intracellular ion homeostasis is impaired and ROS levels are increased, which in turn causes Golgi and endoplasmic reticulum stress. Taken together, these results suggest that TMC7 is required to maintain pH and ion homeostasis, which is needed for acrosome biogenesis. Our findings unveil a novel role for TMC7 in acrosome biogenesis during spermiogenesis.
PPI-hotspotID for detecting protein–protein interaction hot spots from the free protein structure
Authors: Chen Yao Chi , Sargsyan Karen , Wright Jon D , Chen Yu-Hsien , Huang Yi-Shuian , Lim Carmay
Published: September 2024

Experimental detection of residues critical for protein–protein interactions (PPI) is a time-consuming, costly, and labor-intensive process. Hence, high-throughput PPI-hot spot prediction methods have been developed, but they have been validated using relatively small datasets, which may compromise their predictive reliability. Here, we introduce PPI-hotspotID, a novel method for identifying PPI-hot spots using the free protein structure, and validated it on the largest collection of experimentally confirmed PPI-hot spots to date. We explored the possibility of detecting PPI-hot spots using (i) FTMap in the PPI mode, which identifies hot spots on protein–protein interfaces from the free protein structure, and (ii) the interface residues predicted by AlphaFold-Multimer. PPI-hotspotID yielded better performance than FTMap and SPOTONE, a webserver for predicting PPI-hot spots given the protein sequence. When combined with the AlphaFold-Multimer-predicted interface residues, PPI-hotspotID yielded better performance than either method alone. Furthermore, we experimentally verified several PPI-hotspotID-predicted PPI-hot spots of eukaryotic elongation factor 2. Notably, PPI-hotspotID can reveal PPI-hot spots not obvious from complex structures, including those in indirect contact with binding partners. PPI-hotspotID serves as a valuable tool for understanding PPI mechanisms and aiding drug design. It is available as a web server (https://ppihotspotid.limlab.dnsalias.org/) and open-source code (https://github.com/wrigjz/ppihotspotid/).
The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection
Authors: Chakraborty Arijit , Bandyopadhaya Arunava , Singh Vijay K , Kovacic Filip , Cha Sujin , Oldham William M , Tzika A Aria , Rahme Laurence G
Published: September 2024

How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that Pseudomonas aeruginosa (PA), a recalcitrant pathogen, utilizes the quorum sensing (QS) signal 2’-aminoacetophenone (2-AA). Here, we unveil how 2-AA-driven immune tolerization causes distinct metabolic perturbations in murine macrophages’ mitochondrial respiration and bioenergetics. We present evidence indicating that these effects stem from decreased pyruvate transport into mitochondria. This reduction is attributed to decreased expression of the mitochondrial pyruvate carrier (Mpc1), which is mediated by diminished expression and nuclear presence of its transcriptional regulator, estrogen-related nuclear receptor alpha (Esrra). Consequently, Esrra exhibits weakened binding to the Mpc1 promoter. This outcome arises from the impaired interaction between Esrra and the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Ppargc1a). Ultimately, this cascade results in diminished pyruvate influx into mitochondria and, consequently reduced ATP production in tolerized murine and human macrophages. Exogenously added ATP in infected macrophages restores the transcript levels of Mpc1 and Esrra and enhances cytokine production and intracellular bacterial clearance. Consistent with the in vitro findings, murine infection studies corroborate the 2-AA-mediated long-lasting decrease in ATP and acetyl-CoA and its association with PA persistence, further supporting this QS signaling molecule as the culprit of the host bioenergetic alterations and PA persistence. These findings unveil 2-AA as a modulator of cellular immunometabolism and reveal an unprecedented mechanism of host tolerance to infection involving the Ppargc1a/Esrra axis in its influence on Mpc1/OXPHOS-dependent energy production and PA clearance. These paradigmatic findings pave the way for developing treatments to bolster host resilience to pathogen-induced damage. Given that QS is a common characteristic of prokaryotes, it is likely that 2-AA-like molecules with similar functions may be present in other pathogens.
Effective Management of Irritable Bowel Disease (Grahani) through Ayurveda: A Case Report
Authors: Verma Shubham , Sawarkar Punam , Sawarkar Gaurav , Parwe Shweta
Published: September 2024

Grahani is an important part of the Mahasrotas (gastrointestinal tract). Grahani and Agni (digestive fire) have an Adhara Adheya Sambandha (mutual relationship). Jatharagni (digestive fire) governs the process of digestion, supported by the Tridoshas (three bio-humors). Due to a chronic imbalance of the Pachaka Pitta (digestive fire), Saman Vayu (the air entity that aids digestion), and Kledaka Kapha (the type of phlegm involved in digestion), a weak digestive fire (Mandagni) can lead to the release of food in its undigested form (Ama Utpatti), resulting in Grahani Roga. This condition is accompanied by symptoms (Lakshanas) such as Atisrushta Atibadha Mala (loose or constipated stools), Trushna (thirst), Arochaka (lack of taste), Aasyavairasya (altered taste), Praseka (excessive salivation), Shoona Pada Kara (oedma in the hands and feet), Asthisara Ruk (pain in the phalangeal joints and bones), Chhardi (vomiting), Jwara (fever) and Louhagandhi Amlodgara (burps with an iron-like pungent odour). In the present case of a 38-year-old female patient, the histopathology study revealed ulcero-inflammatory strictured colitis with transmural lymphoid follicles, indicative of Inflammatory Bowel Disease (IBD). According to the basic treatment principles of Ayurveda, Grahani (IBD) can be effectively treated using a combination of Shamana (palliative care) and Shodhana Chikitsa (purificatory procedures). The general approach in Grahani treatment involves the use of Agnivardhana (appetiser) drugs with Deepana (digestive stimulant) and Pachana (digestive aid) properties, which work to enhance the digestive fire (Agni). In the present study, the patient had stopped allopathic drugs, and the Ayurvedic treatment proved to be a safe remedy without any side-effects. The present case study demonstrates the critical contribution of Ayurveda to the effective treatment of Grahani (IBD).