bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase Formation and Diffusivity in the Ternary Cu-Zn-In System
Authors: Czeppe Tomasz , Sypien Anna , Wierzbicka-Miernik Anna , Garzeł Grzegorz , Kopyto Marek
Published: February 2022

Formation of the phases in Cu-Zn-In system was investigated by means of diffusion multiples annealed in isothermal conditions. The annealing of three different configurations of joints was performed at increasing temperatures (130, 350, 450 °C): below and above melting temperature of In and above Zn melting temperature. It was found that In revealed the ability for the preferential diffusion in Zn along the grain boundaries, forming the eutectic phase. In all applied temperatures, pure Cu was the barrier for the diffusion of In, while the diffusion of Zn proceeded easily, leading to the formation of binary CuZn phases; the phases from the Cu-In system were not found. The ternary Cu-Zn-In phases were formed at temperatures of 350 and 450 °C, at which the simultaneous diffusion of In and Zn in Cu took place, with participation of liquid In and Zn. The obtained results are the starting point for the calculation of the Cu-Zn-In phase diagram which remains unavailable, in spite of fact that all Cu-Zn, In-Zn and Cu-In binary diagrams are well known.
Recent trends in publications of economic historians in Europe and North America (1980–2019): an empirical analysis
Authors: Fernández-de-Pinedo Nadia , La Parra-Perez Alvaro , Muñoz Félix-Fernando
Published: February 2022

This article analyses the integration of economic history into economics using a unique dataset containing 11,143 articles written by 919 economic historians and published between 1980 and 2019 in leading journals; we also analyzed the authors’ biographical information. Using a probit regression, we find that since 1980, economic historians have increased their likelihood of publishing in Economics or Finance Journals (EFJs) by 12 points. This integration is more marked in North America than in Europe because North American economic historians are more likely to be trained in the discipline of economics. In contrast, a significant share of scholars in Europe are trained in the discipline of economic history. Network visualizations confirm these regional differences: citations to EFJs are much more central in North American scholars’ work. Our findings support Robert Margo’s claim that economic history is currently integrated into economics more often in publications in North America than in Europe.
Treatment Strategies for Malignancies of the External Auditory Canal
Authors: Zhong Shixun , Zuo Wenqi
Published: February 2022

Opinion statement

Malignant tumors of the external auditory canal (EAC) are rare tumors in the head and neck. Delayed diagnosis is not uncommon because the symptoms of early tumors are nonspecific. Various surgical and oncological treatment modalities have been reported. Decision-making depends on pathological feature and stage of the lesions, patient’s general condition and preference, and physician’s experience and skill. Radical surgery is widely accepted as the primary treatment of choice. Postoperative radiotherapy is used more often to improve local and regional control of the disease. Chemotherapy is usually recommended for advanced disease, residual disease, and metastasis. Prognosis is affected by multiple factors such as TNM stage, surgical margin, pathological type and differentiation of tumor, involvement of facial nerve, and so on. Although the survival rate is improved significantly over the past several decades with the development of skull base surgery, neuroradiology, anesthesiology, and oncology, it remains challenging to diagnose and treat EAC malignancies due to the rarity, the local anatomical complexity of temporal bone, and the lack of standard TNM staging system.
Molecular profiling leading to personalized treatment in breast cancer
Authors: Klocker Eva Valentina , Balic Marija , Steger Günther
Published: February 2022

With the development of various targeted therapies in breast cancer, detection of biomarkers for predicting treatment efficacy gains importance. With the definition of intrinsic subtypes, breast cancer has paved the way for personalized treatment. Already known and recently recognized targets play an important role both in metastatic and early breast cancer. As a result, early molecular profiling is becoming a part of early diagnostic work-up. Notwithstanding, further treatment targets and agents are needed, particularly in the most aggressive subtype encompassing heterogenous diseases under the group of triple negative breast cancer.
Overview and Discussion of the Competition on Legal Information Extraction/Entailment (COLIEE) 2021
Authors: Rabelo Juliano , Goebel Randy , Kim Mi-Young , Kano Yoshinobu , Yoshioka Masaharu , Satoh Ken
Published: February 2022

We summarize the 8th Competition on Legal Information Extraction and Entailment. In this edition, the competition included five tasks on case law and statute law. The case law component includes an information retrieval Task (Task 1), and the confirmation of an entailment relation between an existing case and an unseen case (Task 2). The statute law component includes an information retrieval Task (Task 3), an entailment/question answering task based on retrieved civil code statutes (Task 4) and an entailment/question answering task without retrieved civil code statutes (Task 5). Participation was open to any group based on any approach. Eight different teams participated in the case law competition tasks, most of them in more than one task. We received results from six teams for Task 1 (16 runs) and 6 teams for Task 2 (17 runs). On the statute law task, there were eight different teams participating, most in more than one task. Six teams submitted a total of 18 runs for Task 3, 6 teams submitted a total of 18 runs for Task 4, and 4 teams submitted a total of 12 runs for Task 5. Here we summarize the approaches, our official evaluation, and analysis on our data and submission results.
Time Is the Fire in Which We Burn (Out): How Time Perspectives Affect Burnout Tendencies in Health Care Professionals Via Perceived Stress and Self-Efficacy
Authors: Unger Alexander , Papastamatelou Julie , Vowinckel Jonte , Klamut Olga , Heger Anja
Published: February 2022

Aim and Background: The purpose of the current study is to examine the influence of time perspectives (TP) on the burnout-tendency of health care professionals. The concept of TP delivers a construct on how individuals frame their thinking and behavior on the emotional, cognitive and motivational level towards the past, the present and the future. Consequently, we assume that the TP configuration of health care professionals, determines how vulnerable or reluctant they will be to burnout. TP is assumed to influence the stress perception and the degree of self-efficacy which are in turn well-known factors of influence on burnout. Methods: The sample consisted of 398 health care professionals in Germany. We have measured TPs by the Zimbardo Time Perspective Inventory (ZTPI) and the burnout tendencies by the German version of the Maslach Burnout-Inventory (MBI-GS-D). Results: The Past-Negative and Past-Positive perspectives were identified as factors that were significantly associated with the burnout dimensions of emotional exhaustion, cynicism and personal accomplishment. The Present-Fatalistic orientation was only associated with cynicism and the Future dimension with cynicism and personal accomplishment. Furthermore, we observed that high deviations from a Negative Time Perspective (DNTP) caused a decrease on all three burnout dimensions. In addition, the influence of the DNTP on emotional exhaustion, cynicism and personal accomplishment was fully mediated by perceived stress and self-efficacy. Conclusion: We identified time perspective as a substantial factor of influence on burnout for health care professions and observed an underlying mechanism of the influence of DNTP on burnout. Both factors are important for practical therapeutic conclusions, as well as for a better understanding of the role of TP for burnout.
The emergence of the postgenomic gene
Authors: Bellazzi Francesca
Published: February 2022

The identity and the existence of genes has been challenged by postgenomic discoveries. Specifically, the consideration of molecular and cellular phenomena in which genes are embedded has proved relevant for their understanding. In response to these challenges, I will argue that the complexity of genetic phenomena supports the weak emergence of genes from the DNA. In Section 2, I will expose what genes are taken to be in the postgenomic world. In Section 3, I will present the relevant account of emergence. I consider weak emergence as in Franklin and Knox (Studies for the History and Philosophy of Modern Physics, 64, 68–78, 2018), for which a phenomenon is emergent when it displays novelty and robustness. In Section 4, I will argue that genes are weakly emergent since they are novel, improving explanations, and robust in respect to some perturbations. Then, I will conclude in Section 5 that genes’ emergence is a way to allow genes’ flexibility and context dependency, without compromising their existence.
Does catching more fish increase the subjective well-being of fishers? Insights from Bangladesh
Authors: Miñarro Sara , Selim Samiya , Galbraith Eric D.
Published: February 2022

Small-scale fisheries have been associated with the subjective well-being of coastal communities through their links with culture, identity, and social cohesion. But although fish catches are usually considered the primary ecosystem service that benefits fishers, little is known about how subjective well-being is influenced by the fishing activity itself. Here, we applied the experience sampling method in two small-scale fisheries in Bangladesh to assess the effects of fishing on fishers’ occurrence of positive and negative affect, two measures of subjective well-being. We found that fishing activities were not directly associated with increased momentary affect and that the frequency of positive affect actually decreased as the fishing trip progressed. Furthermore, although very low catches were associated with less positive affect, the highest frequency of positive affect was achieved with relatively small catches. Our results imply that the benefits provided by small-scale fisheries to the momentary subjective well-being of fishers are not strongly related to the actual catching of fish.
Heralds of Change: In the Aftermath of Skanska (C-724/17) and Sumal (C-882/19)
Authors: Freund Benedikt
Published: February 2022

The Court of Justice of the European Union (CJEU) can be placed at the origins of the pan-European awakening of private enforcement of EU competition law. The CJEU has, in a steadfast and unwavering manner, advocated for the rights of victims of competition law infringements, elevating cartel damages proceedings from a rare sight to a well-established phenomenon. In its judgmentVantaan kaupunki v. Skanska Industrial Solutions Oy and others(Skanska), the CJEU ruled that the circle of persons liable for the harm resulting from an anticompetitive behaviour is to be determined according to the concept of undertaking as referred to in Art. 101 of the Treaty on the Functioning of the European Union (TFEU). InSumal v. Mercedes Benz Trucks Espana(Sumal) the Court clarified under which circumstances distinct legal entities within a group of companies form one single undertaking and are thus  to be made the defendant in cartel damages proceedings. The CJEU’s judgments inSkanksaandSumalmark a certainly provisional climax in the evolution of private enforcement of EU competition law. This article aims to depict the conceptual backbone of both judgments and to explore possible consequences in regard to liability within groups of companies.
Adipose tissue in COVID-19: detection of SARS-CoV-2 in adipocytes and activation of the interferon-alpha response
Authors: Basolo A. , Poma A. M. , Bonuccelli D. , Proietti A. , Macerola E. , Ugolini C. , Torregrossa L. , Giannini R. , Vignali P. , Basolo F. , Santini F. , Toniolo A.
Published: February 2022

Objective

Obesity is a recognized risk factor for the progression to severe forms of COVID-19, yet the mechanisms of the association are unclear.

Methods

Subcutaneous abdominal adipose tissue specimens of subjects deceased from COVID-19 (n = 23) were compared to those of controls dying abruptly from causes other than infectious (accidental trauma, sudden cardiac death). Alterations of lung parenchyma consistent with moderate to severe disease were detected in all COVID-19 cases, not in controls. Investigations included: histopathologic features, detection of virus antigens and genome, characterization of infiltrating leukocytes, transcription levels of immune-related genes.

Results

By RT-PCR, the SARS-CoV-2 genome was detected in the adipose tissue of 13/23 (56%) cases of the COVID-19 cohort. The virus nucleocapsid antigen was detected in the cytoplasm of 1–5% adipocytes in 12/12 COVID-19 cases that were virus-positive by PCR in the adipose tissue (one case could not be assessed due insufficient tissue). The adipose tissue of COVID-19 cases showed leukocyte infiltrates and upregulation of the interferon-alpha pathway. After adjusting for age and sex, the activation score of IFN-alpha was directly related with transcription levels of the ACE2 gene, a key entry factor of SARS-CoV-2.

Conclusions

In lethal COVID-19 cases, the SARS-CoV-2 nucleocapsid antigen has been detected in a sizeable proportion of adipocytes, showing that the virus may directly infect the parenchymal cells of subcutaneous fat. Infection appears to activate the IFN alpha pathway and to attract infiltrating leukocytes. Due to the huge numbers of adipocytes in adults, the adipose tissue represents a significant reservoir for SARS-CoV-2 and an important source of inflammatory mediators.
Methods for the dietary assessment of adult kidney stone formers: a scoping review
Authors: Legay Constance , Krasniqi Tropoja , Bourdet Alice , Bonny Olivier , Bochud Murielle
Published: February 2022

Background

Kidney stones are a frequent and potentially severe condition, affecting 5–10% of the European population. Causes are multifactorial, diet in particular plays a major role in the formation and management of kidney stones. The aim of this scoping review is to assess the methods used to study the diet of adult kidney stone formers.

Methods

We conducted a systematic search in Medline Ovid SP, Embase, Cinahl, Cochrane (CENTRAL), Web of Sciences databases on June 10th, 2020. Self-report methods (such as food frequency questionnaires or 24-h dietary recalls), objective nutritional biomarkers and controlled diets were considered. We analyzed the selected publications based on the origin of participants, study design and dietary assessment methods used.

Results

We screened 871 publications and included 162 of them. Most studies included participants from North America and Europe and were observational. Short and cost-effective tools such as food frequency questionnaires and other questionnaires were the most frequently used. Moreover, food diary was a frequently selected method to study the diet of kidney stone formers. New technologies (e.g. online questionnaires, phone applications, connected tools) were rarely used.

Conclusion

Accurate reporting of the methods used in nutritional studies is of key importance to interpret results and build evidence. Assessing long-term dietary intake is still a challenge for nutritional epidemiology. A combination of self-report methods with objective dietary biomarkers and new technologies probably represents the best way forward.

Graphical abstract
Measuring the Effect of Strain Rate on Deformation and Damage in Fibre-Reinforced Composites: A Review
Authors: Perry J. I. , Walley S. M.
Published: February 2022

This review aims to assess publications relevant to understanding the rate-dependent dynamic behaviour of glass- and carbon-fibre reinforced polymer composites (FRPs). FRPs are complex structures composed of fibres embedded in a polymer matrix, making them highly anisotropic. Their properties depend on their constituent materials as well as micro-, meso- and macro-scale structure. Deformation proceeds via a variety of damage mechanisms which degrade them, and failure can occur by one or more different processes. The damage and failure mechanisms may exhibit complex and unpredictable rate-dependence, with certain phenomena only observable under specific loading conditions or geometries. This review focusses on experimental methods for measuring the rate-dependent deformation of fibre composites: it considers high-stain-rate testing of both specimens of ‘simple’ geometry as well as more complex loadings such as joints, ballistic impact and underwater blast. The effects of strain rate on damage and energy-based processes are also considered, and several scenarios identified where strength and toughness may substantially decrease with an increase in strain rate.
Review on Improvement, Modeling, and Application of Ionic Polymer Metal Composite Artificial Muscle
Authors: He Qingsong , Yin Guoxiao , Vokoun David , Shen Qi , Lu Ji , Liu Xiaofang , Xu Xianrui , Yu Min , Dai Zhendong
Published: February 2022

Recently, researchers have concentrated on studying ionic polymer metal composite (IPMC) artificial muscle, which has numerous advantages including a relatively large strain under low input voltage, flexibility, high response, low noise, light weight, and high driving energy density. This paper reports recent developments in IPMC artificial muscle, including improvement methods, modeling, and applications. Different types of IPMCs are described, along with various methods for overcoming some shortcomings, including improvement of Nafion matrix membranes, surface preparation of Nafion membranes, the choice of high-performing electrodes, and new electro-active polymers for enhancing the properties of IPMCs. IPMC models are also reviewed, providing theoretical guidance for studying the performance and applications of IPMCs. Successful applications such as bio-inspired robots, opto-mechatronic systems, and medical engineering are discussed.
Individueller religiöser Pluralismus – Perspektiven für kulturpsychologische Forschung
Authors: Popp-Baier Ulrike
Published: February 2022

Vor einigen Jahren plädierte der Soziologe Peter Berger für einen Paradigmenwechsel, um die Beziehung zwischen Moderne und Religion zu verstehen. Er schlug vor, die Säkularisierungstheorie durch eine Theorie des Pluralismus zu ersetzen und akzentuierte dabei zwei Formen des Pluralismus: Die Koexistenz verschiedener Religionen und die Koexistenz religiöser und säkularer Diskurse in der Gesellschaft wie auch im individuellen Bewusstsein. Linda Woodhead ergänzte diese zwei Formen des religiösen Pluralismus durch eine dritte Form der Dedifferenzierung, die sich durch das Aufweichen klarer Grenzen zwischen Religionen und zwischen dem Religiösen und dem Säkularen auszeichne. Sie sieht in allen drei Pluralismen Erklärungspotenzial, um den Anstieg der sogenannten nones in vielen postindustriellen Gesellschaften zu begreifen. In diesem Beitrag wird anhand von Beispielen aus empirischen Forschungsprojekten auf das analytische Potenzial der drei Pluralismen im Hinblick auf das Phänomen eines individuellen religiösen Pluralismus verwiesen und mit Vorschlägen für entsprechende kulturpsychologische Analysen verbunden.
Shared Measures
Authors: Kroll Alexander
Published: February 2022

Traditionally, performance metrics and data have been used to hold organizations accountable. But public service provision is not merely hierarchical anymore. Increasingly, we see partnerships among government agencies, private or nonprofit organizations, and civil society groups. Such collaborations may also use goals, measures, and data to manage group efforts, however, the application of performance practices here will likely follow a different logic. This Element introduces the concepts of “shared measures” and “collective data use” to add collaborative, relational elements to existing performance management theory. It draws on a case study of collaboratives in North Carolina that were established to develop community responses to the opioid epidemic. To explain the use of shared performance measures and data within these collaboratives, this Element studies the role of factors such as group composition, participatory structures, social relationships, distributed leadership, group culture, and value congruence.
Coca-Cola’s Cape Town Crisis: Examining Companies’ Water Rights Obligations in a Changing Climate
Authors: Marcoux Shannon
Published: February 2022

While Coca-Cola portrays itself as a ‘water neutrality’ leader, its failures during Cape Town’s water crisis exemplify the changing nature of corporate human rights obligations in the face of climate change. Between 2015 and 2018, drought conditions plunged Cape Town into a crisis, leading to increasingly strict household water restrictions and depriving families of their constitutionally guaranteed water allowance.1 However, in December 2017, when Cape Town officials called for a 45% reduction in commercial water use, Coca-Cola’s local independent bottler – Coca-Cola Peninsula Beverages (CCPB) – refused to reduce its 44 million-litre monthly withdrawals.2 The city subjected households to water restrictions and price increases up to 556%, while businesses only saw a 104% price increase with no consumption restrictions.3
Trimethoprim-sulfamethoxazole resistance patterns among Staphylococcus aureus in the United States, 2012–2018
Authors: Ham D. Cal , Fike Lucy , Wolford Hannah , Lastinger Lindsey , Soe Minn , Baggs James , Walters Maroya Spalding
Published: February 2022

We reviewed trimethoprim-sulfamethoxazole antibiotic susceptibility testing data among Staphylococcus aureus using 3 national inpatient databases. In all 3 databases, we observed an increases in the percentage of methicillin-resistant Staphylococcus aureus that were not susceptible to trimethoprim-sulfamethoxazole. Providers should select antibiotic regimens based on local resistance patterns and should report changes to the public health department.
On the direction of the re-entrant jet and the limiting cavity flow configurations
Authors: Maklakov Dmitri V. , Lexina Anna I.
Published: February 2022

In this paper, we investigate an old classical free streamline problem, namely, the two-dimensional re-entrant jet cavity flow past an obstacle. It is well known that for the re-entrant jet model, the direction of the jet is a free parameter that can be specified arbitrarily. To fix this uncertainty, we make a complementary conjecture: the direction should be chosen so that the mean kinetic energy of the remote part of the jet is minimal. Considering cavity flows over an oblique flat plate as an example, we show numerically that the direction is almost opposite to the incident flow. In addition, we present an analytical confirmation of this conclusion that is independent of the obstacle shape. Further, considering again the oblique flat plate as an example, we give an answer to the following question: What happens when the angle of attack tends to zero and the cavity number is finite? We demonstrate that for the limiting configurations, the re-entrant jet vanishes, and the limit is a free-surface flow with a symmetric bubble above the plate and two stagnation points on the lower side of the plate. For this limit we construct a simple exact analytical solution.
A heavy body translating in a boundary layer: ‘crash’, ‘fly away’ and ‘bouncing’ responses
Authors: Jolley Ellen M. , Smith Frank T.
Published: February 2022

The study concerns a slender, heavy body moving with streamwise velocity in a boundary layer. Modelling assumptions on body size reduce the governing equations for the body motion to a pair of nonlinear integro-differential equations (IDEs) which displays a wide range of distinguished behaviours, including eventual collision with the wall (‘crash’), escape to infinity (‘fly away’) and repeatedly travelling far from the wall and back again without ever colliding or escaping (‘bouncing’). The paper gives a survey of the variety of behaviour, as well as asymptotic analysis and insight into each category of fluid/body interaction and the conditions under which crash, fly away and bouncing occur.
A critical deliberation of the ‘species complex’ status of the globally spread colonial ascidian Botryllus schlosseri
Authors: Reem Eitan , Douek Jacob , Rinkevich Baruch
Published: February 2022

The accurate taxonomic identity for the worldwide-distributed invasive ascidian Botryllus schlosseri has not been resolved. Employing molecular tools, primarily mtDNA, previous studies unveiled five divergent clades (A–E), suggesting a complex of five cryptic species. A recent study allocated clades A and E to different species. Here, worldwide B. schlosseri's COI distribution map has been drawn, based on 2927 specimens, elucidating 160 haplotypes (100 singletons). Clade A emerged as the most abundant and globally widespread, while other clades had more limited distributions (primarily B, C). Inter-clade and intra-clade divergences were similar, with no clear barcoding gaps between the clades, illuminating no more than two putative OTUs. Network analyses for the genetic similarities among the clades' haplotypes identified different groups, depending on threshold values and away from the suggested clades' boundaries. Three additional genetic markers (H3, 18S, 28S) disclosed clade A, segregating from other clades and clades D and E strongly integrating. Allorecognition assays between clades resulted in indifference and rejection outcomes, characteristics of the within-species allorecognition repertoire. The question as to whether Botryllus schlosseri is a single species or a species complex is further discussed, leading to the assertion that while it is a widely variable species, there is not enough evidence for its designation as a species complex.
Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium
Authors: Wang KangCheng , Hu YuFei , Yan ChaoGan , Li MeiLing , Wu YanJing , Qiu Jiang , Zhu XingXing ,   the REST-meta-MDD Consortium
Published: February 2022

Background

Neuroimaging studies on major depressive disorder (MDD) have identified an extensive range of brain structural abnormalities, but the exact neural mechanisms associated with MDD remain elusive. Most previous studies were performed with voxel- or surface-based morphometry which were univariate methods without considering spatial information across voxels/vertices.

Methods

Brain morphology was investigated using voxel-based morphometry (VBM) and source-based morphometry (SBM) in 1082 MDD patients and 990 healthy controls (HCs) from the REST-meta-MDD Consortium. We first examined group differences in regional grey matter (GM) volumes and structural covariance networks between patients and HCs. We then compared first-episode, drug-naïve (FEDN) patients, and recurrent patients. Additionally, we assessed the effects of symptom severity and illness duration on brain alterations.

Results

VBM showed decreased GM volume in various regions in MDD patients including the superior temporal cortex, anterior and middle cingulate cortex, inferior frontal cortex, and precuneus. SBM returned differences only in the prefrontal network. Comparisons between FEDN and recurrent MDD patients showed no significant differences by VBM, but SBM showed greater decreases in prefrontal, basal ganglia, visual, and cerebellar networks in the recurrent group. Moreover, depression severity was associated with volumes in the inferior frontal gyrus and precuneus, as well as the prefrontal network.

Conclusions

Simultaneous application of VBM and SBM methods revealed brain alterations in MDD patients and specified differences between recurrent and FEDN patients, which tentatively provide an effective multivariate method to identify potential neurobiological markers for depression.
Understanding agoraphobic avoidance: the development of the Oxford Cognitions and Defences Questionnaire (O-CDQ)
Authors: Rosebrock Laina , Lambe Sinéad , Mulhall Sophie , Petit Ariane , Loe Bao S , Saidel Simone , Pervez Maryam , Mitchell Joanna , Chauhan Nisha , Prouten Eloise , Chan Cindy , Aynsworth Charlotte , Murphy Elizabeth , Jones Julia , Powling Rosie , Chapman Kate , Dudley Robert , Morrison Anthony , O’Regan Eileen , Clark David M , Waite Felicity , Freeman Daniel
Published: February 2022

Background:

Many patients with mental health disorders become increasingly isolated at home due to anxiety about going outside. A cognitive perspective on this difficulty is that threat cognitions lead to the safety-seeking behavioural response of agoraphobic avoidance.

Aims:

We sought to develop a brief questionnaire, suitable for research and clinical practice, to assess a wide range of cognitions likely to lead to agoraphobic avoidance. We also included two additional subscales assessing two types of safety-seeking defensive responses: anxious avoidance and within-situation safety behaviours.

Method:

198 patients with psychosis and agoraphobic avoidance and 1947 non-clinical individuals completed the item pool and measures of agoraphobic avoidance, generalised anxiety, social anxiety, depression and paranoia. Factor analyses were used to derive the Oxford Cognitions and Defences Questionnaire (O-CDQ).

Results:

The O-CDQ consists of three subscales: threat cognitions (14 items), anxious avoidance (11 items), and within-situation safety behaviours (8 items). Separate confirmatory factor analyses demonstrated a good model fit for all subscales. The cognitions subscale was significantly associated with agoraphobic avoidance (r = .672, p < .001), social anxiety (r = .617, p < .001), generalized anxiety (r = .746, p < .001), depression (r = .619, p < .001) and paranoia (r = .655, p < .001). Additionally, both the O-CDQ avoidance (r = .867, p < .001) and within-situation safety behaviours (r = .757, p < .001) subscales were highly correlated with agoraphobic avoidance. The O-CDQ demonstrated excellent internal consistency (cognitions Cronbach’s alpha = .93, avoidance Cronbach’s alpha = .94, within-situation Cronbach’s alpha = .93) and test–re-test reliability (cognitions ICC = 0.88, avoidance ICC = 0.92, within-situation ICC = 0.89).

Conclusions:

The O-CDQ, consisting of three separate scales, has excellent psychometric properties and may prove a helpful tool for understanding agoraphobic avoidance across mental health disorders.
The old boy network: are the professional networks of female executives less effective than men's for advancing their careers?
Authors: Lalanne Marie , Seabright Paul
Published: February 2022

We investigate the impact of professional networks on men's and women's earnings, using a dataset of European and North American executives. The size of an individual's network of influential former colleagues has a large positive association with remuneration, with an elasticity of around 21%. However, controlling for unobserved heterogeneity using various fixed effects as well as a placebo technique, we find that the real causal impact of networks is barely positive for men and significantly lower for women. We provide suggestive evidence indicating that the apparent discrimination against women is due to two factors: first, both men and women are helped more by own-gender than other-gender connections, and men have more of these than women do. Second, a subset of employers we identify as ‘female friendly firms’ recruit more women but reward networks less than other firms.
The Lynching of Italians and the Rise of Antilynching Politics in the United States
Authors: Seguin Charles , Nardin Sabrina
Published: February 2022

In the years following the end of Reconstruction lynching became a favored method of White supremacist terror in the US South. Despite presidential efforts to quell racist violence in the 1870s, throughout the 1880s, presidents tended to ignore lynchings, and northern newspapers legitimized lynchings as a form of “rough justice.” Over time, however, presidents began to denounce lynchings, and northern newspapers began to argue that lynching shamed the United States before the “civilized world.” Scholars disagree, however, on both when and why the presidency and newspapers began to oppose lynching. We show that the lynching of Italian nationals catalyzed opposition to lynching from both the presidency and national newspapers starting in 1891. Using new data from across the United States, Great Britain, and Italy, we trace the political impact of the lynching of Italians. Lynchings of Italians brought immediate political pressure from the Italian embassy and generated broad international condemnation of the lynching of Italians in the United States. Ida B. Wells exploited this international outrage on her 1894 British tour to draw international attention to the lynching of Black Americans. International condemnation led presidents that were sensitive to their international reputation to denounce lynching, first of Italians, but later of Black victims. Our account dates the rise of antilynching politics earlier than accounts that focus on Ida B. Wells’s British tour of 1894, or the NAACP’s antilynching campaign post–World War I.
Possible Ionospheric Influence on Substorm Onset Location
Authors: Elhawary R. , Laundal K. M. , Reistad J. P. , Hatch S. M.
Published: February 2022

Auroral substorm onset locations are highly unpredictable. Previous studies have shown that the By component of the interplanetary magnetic field (IMF) explains ∼5% of the variation in onset magnetic local time (MLT), while solar wind conditions and the other IMF components have even less explanatory power. In this study, we show that the level of geomagnetic activity before substorm onset, as indicated by the AL index, explains an additional ∼5% of the variation in onset MLT. We discuss our results with regard to recent modeling studies, which show that gradients in the ionospheric Hall conductance can lead to a duskward shift of the magnetotail dynamics. Our findings suggest that this magnetosphere‐ionosphere coupling effect may also influence the location of substorm onsets.
Role of Sea‐Surface Salinity in Simulating Historical Decadal Variations of Atlantic Meridional Overturning Circulation in a Coupled Climate Model
Authors: Zhang Qiuying , Chang Ping , Yeager Stephen G. , Danabasoglu Gokhan , Zhang Shaoqing
Published: February 2022

Extending climate prediction from seasonal to decadal timescales requires realistic initialization of not only upper ocean heat content but also the Atlantic meridional overturning circulation (AMOC). However, it remains a major challenge to realistically initialize AMOC in a coupled system while also maintaining a balanced atmosphere‐ocean initial state. This study demonstrates the feasibility of generating fully coupled historical states with realistic AMOC variability. Employing a forced ocean—sea‐ice (FOSI) model simulation as the “truth,” we show reproducibility of key features of historical AMOC decadal variability in a fully coupled model by restoring sea‐surface salinity, in addition to sea‐surface temperature restoring widely used in seasonal prediction. The atmospheric state of the restored coupled model solution is much closer to that of the free coupled simulation than to the observations used in FOSI, pointing to potential advantages of using this approach for initializing decadal predictions with reduced ocean initialization shock.
Spatial Scales of the Velocity Shear Layer and Kelvin‐Helmholtz Waves on the Magnetopause: First Statistical Results
Authors: Zhou Yue , Shue Jih‐Hong , Hasegawa Hiroshi , Lu Jianyong , Wang Ming , Zhang Hanxiao
Published: February 2022

Using data taken by the ARTEMIS spacecraft near Moon, we statistically study the properties of Kelvin‐Helmholtz (KH) waves and the thicknesses (ΔY) of initial velocity shear layers on the magnetopause at lunar distance. Based on a total of 48 KH wave events and 14 estimates of ΔY, the average KH wavelength (λX) and ΔY are found to be 16.05 RE and 0.53 RE at lunar distance, respectively, which are larger than those at near‐Earth magnetopause. The λX to ΔY ratio ranges from 18 to 41 at lunar distance, way beyond the range (6–13) predicted by the linear theory. This result indicates that the KH waves observed at lunar distance are not of the fastest growing mode according to linear theory. This study poses the first statistical study on λX and ΔY, providing insights into the generation and development of KH waves at lunar distance.
3‐D Structure and Development of a Metamorphic Core Complex in the Northern South China Sea Rifted Margin
Authors: Ye Qing , Mei Lianfu , Jiang Dapeng , Xu Xinming , Delogkos Efstratios , Zhang Lili , Camanni Giovanni
Published: February 2022

The 3‐D structure of continental metamorphic core complexes (MCCs) and their coevolution along with the associated extensional detachments are still not well understood. In this study, analysis of a newly acquired high‐resolution 3‐D seismic reflection volume reveals for the first time a well‐imaged MCC in the proximal northern South China Sea (SCS) rifted margin, the Kaiping MCC (KP MCC). These data provide a 3‐D view of the KP MCC and the associated KP detachment fault. The KP MCC is characterized by ascend of ductile midcrustal materials, and it is partially exhumed in the KP9 High. The KP detachment fault displays a domed low‐angle geometry, and is characterized by pronounced NS‐plunging corrugations, among which two megacorrugations of tens of kilometers are revealed. Evidence show that the KP MCC developed according to the classical rolling‐hinge model. A group of secondary normal faults and fractures, which are parallel to the axis of the KP MCC and offset the KP detachment surface at the crest of the MCC, developed in response to inelastic bending during progressive warping of the footwall. The migration of the domal seismic reflection layers provides a visual evidence for the kinematic process of the rolling‐hinge activity, during which the brittle‐ductile transition and the rolling hinge gradually migrate as the detachment fault slips. The origin of the KP MCC in the northern SCS margin is suggested to have been favored by the existence of a pre‐existing midcrustal ductile layer and basement structures within the upper brittle crust.
Predictability of Indian Ocean Dipole Over 138 Years Using a CESM Ensemble‐Prediction System
Authors: Song Xunshu , Tang Youmin , Liu Ting , Li Xiaojing
Published: February 2022

In this study, we performed a long‐term ensemble hindcast from 1880 to 2017 (138 years) using the Community Earth System Model (CESM) and conducted a comprehensive investigation of the Indian Ocean Dipole (IOD) predictability. We found that the CESM can produce the IOD prediction skill comparable to that produced by some of the best state‐of‐the‐art coupled general circulation models, achieving a correlation skill of 0.5 for a lead time of one season over the 138 years. The Brier skill score shows one season of the effective probability prediction skill for the below‐ and above‐normal events and no probability prediction skill for the near‐normal events. The potential predictability of the IOD is much higher than the actual prediction skill; for example, the information‐based potential correlation is as high as 0.8 at a 6‐month lead time, suggesting a large scope for improvement in current IOD predictions. Compared with the dispersion component, the signal component dominates the variation in the relative entropy and the relationship between the potential predictability and deterministic prediction skill. An analysis of the IOD prediction skills suggests that the strength of IOD events plays an important role in the IOD prediction skills, regardless of the measurement metrics used to evaluate the prediction skills. Our study also suggested that the remote forcing from the tropical Pacific and the local sea‐air interaction in the tropical Indian Ocean would be two major sources of IOD predictability.
The Dominant Modes of Spring Land Surface Temperature Over Western Eurasia and Their Possible Linkages With Large‐Scale Atmospheric Teleconnection Patterns
Authors: Song Yidi , Chen Haishan , Yang Jingqiu
Published: February 2022

Previous studies suggest that the spring land surface temperature (LST) anomaly over Western Eurasia (WEA; 20°N–70°N, 0–70°E) is a potential driver for Asian even global climate. However, the interannual variability of LST over WEA together with its causes has not received enough attention. Based on multi‐source observations and reanalysis data, three dominant modes of spring LST over WEA were identified, and the roles of atmospheric teleconnection patterns in LST anomalies via altering cloud and water vapor were investigated from the perspective of surface energy budget. The first empirical orthogonal function (EOF1) mode exhibits a homogeneous warming pattern that is closely related to a negatively in‐phase combination of the Scandinavian and East Atlantic/Western Russia (EA/WR) patterns. Under the control of a predominant anomalous anticyclone, the warming is the result of enhanced downward longwave radiation due to more water vapor in a warmer atmosphere associated with anomalous southerly and more incident solar radiation due to reduced cloud cover. The EOF2 mode, which displays a meridional dipole structure, is dominated by the North Atlantic Oscillation. Coupled with an anomalous cyclone and anticyclone over western Europe and around the Caspian Sea, respectively, the former LST anomalies are primarily caused by cloud‐shortwave radiation processes, whereas the latter are dominated by downward longwave radiation due to water vapor. The EOF3 mode, characterized by a zonal dipole pattern, is dominated by the water vapor greenhouse effect related to the Eurasian pattern. The results of the study may provide a valuable signal for climate prediction.
ENSO’s Response to Volcanism in a Data Assimilation‐Based Paleoclimate Reconstruction Over the Common Era
Authors: Dee Sylvia G. , Steiger Nathan J.
Published: February 2022

The tropical response to explosive volcanism remains underconstrained in the paleoclimate record. While the atmosphere cools due to aerosol forcing following volcanic eruptions, modeling evidence suggests that the tropical Pacific responds with compensatory warming. Given the rarity of large volcanic eruptions and the short instrumental record, these modeling results require independent verification. Here, we test for links between volcanism and tropical Pacific dynamics using the newly developed Paleo Hydrodynamics Data Assimilation product (PHYDA), which spans the past 2,000 years. Using Pacific sea surface temperature fields from PHYDA and coincident volcanic eruptions, we test the response of the El Niño–Southern Oscillation (ENSO) to large, tropical volcanic eruptions. We identify a weak El Niño‐like response of the tropical Pacific in the year following sufficiently large, tropical volcanic eruptions. While the response is not significant at the 95% confidence level using superposed epoch analysis (SEA) and self‐organizing maps, a significant result does emerge when employing probability density functions. Our results indicate that the widely used SEA approach, based on composite averaging, may not be sufficiently sensitive to capture an ENSO response in the presence of large internal variability. We additionally conclude that inconsistencies in both the spatial patterns and magnitudes between climate models and PHYDA results indicate that current models overestimate the regional tropical response to volcanic forcing.
Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer
Authors: Lee Yeongun , Dho So Hee , Lee Jiyeon , Hwang Ji-Hyun , Kim Minjung , Choi Won-Young , Lee Jin-Young , Lee Jongwon , Chang Woochul , Lee Min Young , Choi Jungmin , Kim Tae-You , Kim Lark Kyun
Published: February 2022

Despite numerous observations regarding the relationship between DNA methylation changes and cancer progression, only a few genes have been verified as diagnostic biomarkers of colorectal cancer (CRC). To more practically detect methylation changes, we performed targeted bisulfite sequencing. Through co-analysis of RNA-seq, we identified cohort-specific DNA methylation markers: CpG islands of the intragenic regions of PDX1, EN2, and MSX1. We validated that these genes have oncogenic features in CRC and that their expression levels are increased in correlation with the hypermethylation of intragenic regions. The reliable depth of the targeted bisulfite sequencing data enabled us to design highly optimized quantitative methylation-specific PCR primer sets that can successfully detect subtle changes in the methylation levels of candidate regions. Furthermore, these methylation levels can divide CRC patients into two groups denoting good and poor prognoses. In this study, we present a streamlined workflow for screening clinically significant differentially methylated regions. Our discovery of methylation markers in the PDX1, EN2, and MSX1 genes suggests their promising performance as prognostic markers and their clinical application in CRC patients.
Prognostic model for time to achieve independent walking in children with Guillain-Barré syndrome
Authors: Chaweekulrat Peerada , Sanmaneechai Oranee
Published: February 2022

Background

Guillain-Barré Syndrome (GBS) is an immune-mediated peripheral neuropathy. Clinical features and outcomes in children differ from adults. Currently, there is no prognostic model to predict outcomes in children and existing models for adults are not suitable.

Objectives

To identify factors that are associated with outcomes and develop clinical model to predict time to independent walking in children with GBS.

Methods

Between 2005 and 2018, 41 patients with GBS were identified by retrospective chart review. Factors associated with independent walking were analyzed with the Kaplan–Meier method. A prediction model was developed based on regression coefficients from Cox’s proportional hazard model.

Results

The disability score at maximum weakness and nerve conduction study results were associated with independent walking and included in the model. Scores range from 0 to 5. A score of 5 predicts 34 days to independent walking while a score of 0 predicts 5 months (mean 158 days, p = 0.008).

Conclusion

This scoring system for pediatric patients provides predicts the time needed to achieve independent walking, an important milestone of recovery for communication with parents, and to assist clinicians to optimize treatment. Further studies of predictive factors and external validation are needed to improve precision of the model.

Impact

This is the first study to create a prognostic scoring system for individual outcomes in children with GBS.

A clinical prognostic model can predict time to achieve independent walking in individual pediatric patients with GBS.

This model can assist clinicians to optimize treatment and guide decisions on rehabilitation to prevent long-term disability.