bluuebunny/crossref_metadata_2025 huggingface dataset:
The Occurrence of Diseases and Related Factors in a Center for Asylum Seekers in Italy
Authors: Firenze Alberto , Aleo Nicola , Ferrara Clara , Maranto Marianna , La Cascia Caterina , Restivo Vincenzo
Published: October 2015

Introduction

Italy is the main recipient of asylum seekers in the European region, and Sicily is their first point of arrival. This geographical position creates a large job for Health Authorities to identify and deal with the health of immigrants. This study evaluates the prevalence of disease among asylum seekers, assessing which are associated factors.

Methods

A cross-sectional study was conducted to analyse demographic and clinical data in an Acceptance Centres for Asylum Seekers from February 2012 to May 2013. All variables that were found to be significant on unvariable analysis for the most frequent pathologies were included in a multivariable logistic regression model.

Results

Post-traumatic stress disorders with 17.4% and major depression with 7.3% were the most frequent diseases. The factors associated with post-traumatic stress disorders among asylum seekers were: major depression diagnosis (OR=2.91, p=0.004), Pakistan as a country of origin (OR=3.88, p <0.001), the largest number of medical visits (OR=1.02, p=0.033) and refugee status (OR=1.97, p=0.036). The variables linked with the diagnosis of major depression from the multivariable analysis were: suffering from post-traumatic stress disorders (OR=3.83, p <0.001), Pakistan as a country of origin (OR=3.45, p=0.004) and the highest number of visits to psychologist (OR=1.15, p <0.001).

Conclusions

The mental wellbeing of asylum seekers needs special attention, and interventions should be done to prevent the consolidation of psychiatric morbidity. A short psychological screening after the arrival might prove helpful here. Moreover, carefully designed longitudinal studies should be carried out when political recommendations try to change the organization of psychological and healthcare services.
The Role of the Psychosocial Dimension in the Improvement of Quality of Care: A Systematic Review
Authors: Makivić Irena , Kersnik † Janko , Klemenc-Ketiš Zalika
Published: October 2015

The aim of our systematic review was to analyse the published literature on the psychosocial dimension of care in family medicine and its relationship with quality of care. We wanted to find out whether there is any evidence on the psychosocial approach in (family) medicine. The recommended bio-psycho-social approach, besides the biomedical model of illness, takes into account several co-influencing psychological, sociological and existential factors. An online search of nine different databases used Boolean operators and the following selection criteria: the paper contained information on the holistic approach, quality indicators, family medicine, patient-centred care and/or the bio-psycho-social model of treatment. We retrieved 743 papers, of which 36 fulfilled our inclusion criteria. Including the psychosocial dimension in patient management has been found to be useful in the prevention and treatment of physical and psychiatric illness, resulting in improved social functioning and patient satisfaction, reduced health care disparities, and reduced annual medical care charges. The themes of patient-centred, behavioural or psychosocial medicine were quite well presented in several papers. We could not find any conclusive evidence of the impact of a holistic biopsycho-social-approach. Weak and variable definitions of psychosocial dimensions, a low number of welldesigned intervention studies, and low numbers of included patients limited our conclusions.
Prevention and therapy of 1,2-dimethyl hydrazine induced colon carcinogenesis by Ferula assafoetida hydroalcoholic extract / 1,2-dimetilhidrazin ile indüklenmiş kalın bağırsak kanserlerinin Ferula assa-foetida ekstraktı kullanılarak önlenmesi ve tedavisi
Authors: Torabi Fatemeh , Dadkhah Abolfazl , Fatemi Faezeh , Dini Salome , Taghizadeh Mohsen , Malayeri Mohammad Reza Mohammadi
Published: October 2015

Objective: In this study, we have evaluated the chemopreventive and chemotherapeutic effects of Ferula assa-foetida hydroalcoholic extract in 1, 2-dimethyl hydrazine (DMH) induced colon carcinogenesis.

Methods: Male Wistar rats were divided into 6 groups: a negative control group without DMH; control group with injected DMH (20 mg/Kg b.w) and four groups receiving DMH +F. assa- foetida extract (6.25 and 12.5 mg/Kg b.w) as chemopreventive and chemotherapeutic groups. The effects of the extracts were assessed by estimating the hepatic oxidative stress/antioxidant parameters such as malondialdehyde, glutathione and ferric reducing ability of plasma (MDA, GSH, FRAP) and the detoxification enzymes; glutathione S-transferase and Cytochrome P450 (GST and CYP450). Moreover, the colonic β-catenin protein was examined in colon tissues followed by the histopathological analysis.

Results: The results showed that the F. assa-foetida extracts markedly reversed the increased levels of CYP450, FRAP and β-catenin and also modulated the reduction of GST (activities and protein) and GSH levels. Histological observations of liver tissue correlated with the above biochemical findings indicating the decrease in the aberrant crypt foci (ACF) formations in the extract treated groups.

Conclusion: The achieved results suggested the beneficial effect of the extracts on DMH metabolic processes in the colon indicating its chemopreventive and chemotherapeutic effects on colon carcinogenesis induced by DMH.
In the history of Department of Biochemistry of Istanbul Medical Faculty (1933–1957) three German scientists; Werner Lipschitz, Felix Haurowitz and Zdenko Stary / İstanbul Tıp Fakültesi Biyokimya Bölümü tarihinde (1933–1957) üç Alman bilim adamı; Werner Lipschitz, Felix Haurowitz ve Zdenko Stary
Authors: Aras Şükrü , Armutcu Ferah , Dinç Gülten
Published: October 2015

Escaping from the chaotic environment of Germany before World War II, several scientists, some of whom were biochemists, took refuge in Turkey and made huge contributions in the preparations of new university reforms beginning in 1933. During this period, three wellknown biochemistry scholars, Werner Lipschitz, Felix Haurowitz and Zdenko Stary were accepted into the Biochemistry Institute of Istanbul University, and each one of these scientists became the head of this institute respectively. Being at the zenith of their careers, these three scientists spent their most prolific years in the Biochemistry Institute. The first biochemist taking charge of the reforms, Werner Lipschitz, established a fully equipped laboratory during his term in his own right and with the support of some officials. During his stint, he published several articles and a biochemistry book. However, Lipschitz had to challenge some difficulties such as learning Turkish and finding qualified Turkish assistants. Felix Haurowitz and Zdenko Stary, on the other hand, learnt Turkish in a short time and gave their lectures in Turkish. Conducting many studies, encouraging their Turkish assistants to involve in most of these studies and training them attentively, these academicians emphasized the importance of the graduate ‘PhD’ education and tried to give education to all of their assistants. They gave lectures in several fields, designed courses and attracted attention to the science of biochemistry. Besides, they published biochemistry books in Turkish. Thus, they made contributions to the development of scientific mentality in the field of biochemistry in Turkey.
Distribution of genetic polymorphism of CAT C-262T in three Iranian populations / Üç İran popülasyonunda CAT C-262T genetik polimorfizminin dağılımı
Authors: Saadat Mostafa , Mousavi-Kazerooni Fatemeh , Fallahzadeh-Abarghooei Leila
Published: October 2015

Objective: Catalase (CAT) activity is likely to be affected by functional polymorphism of C-262T (rs1001179) in the CAT gene (OMIM: 115500). It is hypothesized that individuals with the lower expressing forms of the CAT polymorphism may be more susceptible to breast cancer. In order to find the allelic frequency of the C-262T polymorphism among Iranian populations, the present study was carried out.

Methods: The total study subjects consisted of 1057, 200, and 200 individuals from Shiraz (Fars province; belong to Persians), Abarku (Yazd province; belong to Persians), and Yasuj (Kohgiluyeh va Boyer-Ahmad province; belong to Lurs), respectively. Genotypic analysis for the CAT C-262T polymorphism was determined by PCR.

Results: The frequency of the T allele was 0.2044±0.0138, 0.1825±0.0193, and 0.1800±0.0192 in Shiraz, Abarku, and Yasuj, respectively. The genotypic frequencies of the control subjects did not show significant deviation from Hardy-Weinberg equilibrium. Statistical analysis indicated that there was no significant difference between these populations for the genotypic distributions of the CAT C-262T polymorphism (χ2=2.73, df=4, P=0.603).

Conclusion: The frequency of the T allele among Iranian populations was very similar to that reported for Caucasians and was higher than Asians and African-American populations.
Comparison of classical and clustering based reference interval calculations for Aspartate Aminotransferase, Alanine Aminotransferase and Gamma-Glutamyl Transferase in serum / Aspartat Aminotransferaz, Alanin Aminotransferaz ve Gama Glutamil Transferaz serum için klasik ve kümelemeye dayalı referans aralık hesaplamalarının karşılaştırılması
Authors: Coşgun Erdal , Topçu Deniz İlhan , Laleli Yahya
Published: October 2015

Objective: There are fixed rules applied to determine the reference intervals (RIs) of the biochemical tests. However, these rules lack for identifying subgroups within the reference population. Therefore, we suggest the clustering method, which determines the sub-groups by taking the correlations between the variables into account in the RIs calculations. In our study, it is aimed to compare the results of the RIs based on the clusters analysis with the results of the conventional method.

Methods: The individuals who applied Ankara Düzen Laboratory for the check-up with normal Ultra Sono Grafi (USG) in 2012-2014 and who have had Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and G-Glutamyl Transferase (GGT); (U/L) results were included in this study. We have excluded the repeated applies of patients, only analyzed the first apply to the laboratory. Reference individuals are composed of 883 people. (610 male, 273 female, 18-70 years). Non-parametric methods were used to determine reference intervals. Fuzzy C-Means clustering method was used to identify sub-groups.

Results: AST, ALT, GGT measurements for all of the check-up individuals were determined by non-parametric method for the three subgroups specified after the Fuzzy- C-Means clustering method and the entire group. According to the reference intervals obtained, the third sub-cluster derived from the group intended to be used as the reference population was observed as a cluster that is narrower, and has similar properties of the actual reference population. However, when the correlations between the tests in the sub-groups are considered, the correlations between GGT-ALT-AST have been observed to be higher while the correlation level between ALT-AST in the group proposed as a real reference population does not change.

Conclusion: In the reference limit studies, instead of the determination of the reference interval for a single group designated as the reference population, we think that, the subgroups which are homogeneous within itself, heterogeneous between themselves should be set in in this group. In determining multiple sub-groups, the relationship between more than one test need to be taken into consideration, and the effect of clustering should be investigated.
An easy two-step purification method for human leucocyte myeloperoxidase / İnsan lökosit miyeloperoksidazı saflaştırılması için kolay 2 basamaklı yöntem
Authors: Sarkarati Bahram , Akyol Tulay Karaağaç , Kılınç Kamer
Published: October 2015

Objective: The object of this study is to describe a simple, rapid and cost effective method for purification of human leucocyte myeloperoxidase from a single donor. Myelopeoxidase (MPO) was purified by a two step procedure consisting of concanavalin-A Sepharose 4B affinity chromatography followed by CM-Sephadex cation exchange chromatography.

Methods: Leucocytes from a single donor collected by leucopheresis were used in purification studies. MPO was solubilized and extracted from leucocytes by homogenization in phosphate buffer containing 1% HETAB (hexadecyltrimethylammonium bromide). MPO containing soluble material was applied onto concanavalin-A Sepharose 4B affinity gel, and was eluted with methyl-a- D-manno-piranoside. Fractions with MPO activity were pooled, dialyzed and applied onto CM-sephadex cation exchange gel, and was eluted from the column at weak cationic pH with linear NaCl gradient.

Results: By the use of two chromatographic procedures, MPO was purified from human leucocytes with 70% yield. Purity of MPO was checked by determining the Reinheit Zahl (RZ) value (A430/A280). The RZ value of 0.86 indicated that the purified enzyme was highly homogenous as compared to reported experimental values (ranging from 0.82 to 0.88) and pure commercial enzyme with the RZ value of 0.84.

Conclusion: In comparison with earlier purification methods, the purification method reported here has higher recovery rate and high purity together. Use of leucocytes with leucopheresis origin help us to omit the leucocyte isolation step and omitting of ammonium sulphate precipitation steps also help us to reduce the cost and is shortened the time of purification.
Structure and Internal Dynamics of Acid K Salt of (E)-2-hydroxyimino-2-cyanoacetic Acid Ethyl Ester
Authors: Rachwalska Małgorzata , Woźniak-Braszak Aneta , Nitek Wojciech , Urbanek Zbigniew , Hołderna-Natkaniec Krystyna
Published: October 2015

An investigation of the internal dynamic of molecular groups existing
in a molecule of acid K salt of (E)-2-hydroxyimino-2-cyanoacetic
acid ethyl ester is the subject of the work. Using the NMR method we
could find such types of motions which could well describe the
experimental temperature dependences of spin lattice relaxation time,
and the second moment of experimental 1H NMR line. Those
techniques of the 1H NMR method allow one to draw
conclusions on activation parameters of following motions:
reorientation of methyl group, reorientation of ethyl group, H
jump in the hydrogen bond bridge, anisotropic (axial) reorientation of
the whole molecule around
O⋯H–O chemical
bonds.
Collisional Relaxation of NCN: An Experimental Study with Laser-Induced Fluorescence
Authors: Hetzler Jens , Olzmann Matthias
Published: October 2015

Collisional relaxation of NCN produced by photolysis of
NCN3 at a wavelength of 248 nm has been
investigated with laser-induced fluorescence (LIF) in a temperature
range of 240–293 K and a pressure range of
10–800 mbar with different bath gases (He,
Ne, Ar, Kr, H2, N2,
O2, and N2O). LIF excitation spectra were
recorded, and LIF intensity-time profiles experimentally obtained at
an excitation wavelength of 329.01 nm have been fitted with
biexponential functions. The pressure and bath gas dependence of the
rate coefficients obtained was rationalized in terms of a simple
Landau–Teller/Schwartz–Slawsky–Herzfeld model, and notable
influences of vibrational energy transfer to the rate of the overall
relaxation process have been found. Evidence was obtained for
a two-channel vibrational relaxation in NCN.
Comparative Analysis of High-Velocity Versus Low-Velocity Exercise on Outcomes After Total Knee Arthroplasty: A Randomized Clinical Trial
Authors: Kelly Marie A. , Finley Margaret , Lichtman Steven W. , Hyland Matthew R. , Edeer Ayse Ozcan
Published: October 2015

Background and Purpose:

High-velocity (HV) exercise is defined as performing a concentric muscle contraction as fast as possible, or in 1 second or less. Low-velocity (LV) exercise is defined as using 2 seconds to complete the contraction. A comparison of HV to LV exercise performed by community dwelling older adults indicates that HV exercise produces greater gains in power and scores for the 8-ft up-and-go, 30-seond chair stand, and continuous scale physical function performance tests. The effectiveness of HV strengthening exercises has not been identified for individuals who undergo total knee arthroplasty (TKA). The purpose of this research study was to compare the effects of a 6-week exercise program, using either LV or HV contractions, on functional performance, gait, and pain of individuals who have undergone TKA.

Methods:

Adults aged 60 to 89 years with a mean (standard deviation) age of 71.2 (6.8) years who underwent TKA an average of 15 days prior were randomly assigned to an HV exercise (n = 19) or LV exercise (n = 19) training group. The training program lasted for 12 sessions, over 6 to 7 weeks. The primary outcome was functional performance rated with the 6-Minute Walk Test. Secondary measures were the stair climb test, Timed Up and Go test, gait velocity, gait deviations measured with the Gait Abnormality Rating Scale, and pain via a visual analog scale. A 2×2 mixed model analysis of variance (group × time) was used for all outcomes. Comparison between LV and HV groups for posttest gait velocity and Gait Abnormality Rating Scale used independent t test and Mann-Whitney U test, respectively.

Results:

At baseline no differences between groups were noted for sex, age, and height. The LV group weighed more and had more comorbid conditions. Spearman's ρ demonstrated that the greater comorbidities of the LV group correlated with a slower stair climb test at baseline. At posttest both groups exhibited significantly improved scores for all outcome measurements except the visual analog scale for pain. The HV group, but not the LV group, reported a significant decrease in pain at the end of the 6-week training program.

Conclusions:

Both HV and LV progressive exercises equally improve functional performance. Only the HV group reported significantly decreased pain at posttest.
Relationship of Sit-to-Stand Lower-Body Power With Functional Fitness Measures Among Older Adults With and Without Sarcopenia
Authors: Glenn Jordan M. , Gray Michelle , Binns Ashley
Published: October 2015

Background and Purpose:

When evaluating health in older adults, batteries of tests are typically utilized to assess functional fitness. Unfortunately, physician's visits are time-sensitive, and it may be important to develop faster methods to assess functional fitness that can be utilized in professional or clinical settings. Therefore, the purpose of this investigation was to examine the relationship of sit-to-stand (STS) power generated through the STS task with previously established measures of functional fitness, specifically strength, endurance, speed, agility, and flexibility in older adults with and without sarcopenia.

Methods:

This study consisted of 57 community-dwelling older adults (n = 16 males; n = 41 females). Functional fitness was assessed using the Short Physical Performance Battery (SPPB), Senior Fitness Test, handgrip, gait speed (habitual and maximal), balance, and STS power generated via the Tendo Weightlifting Analyzer. On the basis of data distribution, second-degree polynomial (quadratic) curvilinear models (lines of best fit) were applied for the relationships of 5-time STS time with average and peak power. Zero-order correlations were evaluated between STS power and all other functional fitness measures. Older adults with sarcopenia were also identified (n = 15), and relationships were reevaluated within this subset.

Results:

STS power (average and peak) was significantly (P ≤ .01) correlated with physical performance measured via previously established assessments. For average power, this was observed during the senior fitness test (6-minute walk [r = 0.39], 8-ft up-and-go [r = −0.46], arm curl [r = 0.46], and chair stand [r = 0.55]), SPPB (5-time STS time [r = −0.63] and 8-ft walk [r = −0.32]), and other independent functional fitness measures (grip strength [r = 0.65] and maximal gait speed [r = −0.31]). Similar results were observed for peak power during the senior fitness test (6-minute walk [r = 0.39], 8-ft up-and-go [r = −0.46], arm curl [r = 0.45], chair stand [r = 0.52], and sit-and-reach [r = −0.27]), SPPB (5-time STS time [r = −0.60] and 8-ft walk [r = −0.33]), and other independent functional fitness measures (grip strength [r = 0.70] and maximal gait speed [r = −0.32]). Within the sarcopenic subset, for average and peak power, respectively, significant relationships were still retained for handgrip strength (r = 0.57 and r = 0.57), 6-minute walk (r = 0.55 and r = 0.61), chair stand (r = 0.76 and r = 0.81), and 5-time STS time (r = −0.76 and r = −0.80) tests.

Discussion/Conclusions:

STS power generated via the STS task significantly relates to commonly administered functional fitness measures. These relationships also appear to exist when evaluating these relationships in older adults with sarcopenia. STS power may be utilized as an independent measure of functional fitness that is feasible to incorporate in clinical settings where time and space are often limiting factors.
Mutations in the maternally imprinted gene MKRN3 are common in familial central precocious puberty
Authors: Simon Dominique , Ba Ibrahima , Mekhail Nancy , Ecosse Emmanuel , Paulsen Anne , Zenaty Delphine , Houang Muriel , Jesuran Perelroizen Monique , de Filippo Gian-Paolo , Salerno Mariacarolina , Simonin Gilbert , Reynaud Rachel , Carel Jean-Claude , Léger Juliane , de Roux Nicolas
Published: October 2015

Context and objective

Idiopathic central precocious puberty (iCPP) is defined as early activation of the hypothalamic–pituitary–gonadal axis in the absence of identifiable central lesions. Mutations of the makorin RING finger 3 (MKRN3) gene are associated with iCPP. We aimed to assess the frequency of MKRN3 mutations in iCPP and to compare the phenotypes of patients with and without MKRN3 mutations.

Design

An observational study was carried out on patients recruited at pediatric hospitals in France and Italy. Forty-six index CPP cases were screened for mutations in the MKRN3 coding sequence: 28 index cases of familial cases and 18 cases did not report any familial history of CPP. The endocrine phenotype was compared between MKRN3 mutated and non-mutated patients.

Results

MKRN3 mutations were identified in one sporadic and 13 familial cases. We identified five new heterozygous missense mutations predicted to be deleterious for protein function and two frameshift mutations, one new and the other recurrent, predicted to result in truncated proteins. Age at puberty onset varied very little among patients with MKRN3 mutations and puberty occurred earlier in these patients than in those without MKRN3 mutations (6.0 years (5.4–6.0) vs 7.0 years (6.0–7.0), P=0.01).

Conclusions

MKRN3 mutations are common in familial iCPP. MKRN3 is one of the gatekeepers of the postnatal activation of the gonadotropic axis.
doble de ley
Authors: Vázquez-Romero José Manuel
Published: October 2015

Travesía que, partiendo del debate de la antropología jurídica dogmática sobre la prevalencia del orden normativo para la institución del sujeto, ejemplificado en un proceso jurídico (el affaire Perruche), discurre después por los vericuetos de la micropolítica de la subjetividad, tal y como se plantea en la figura límite del derecho íntimo de la tradición iusfilosófica del krauso-institucionismo español, para así facilitar el planteamiento de las relaciones entre biopolítica y derecho desde consideraciones foucaultianas, finalizando en el esbozo de un vis a vis entre rostro levinassiano y desrostrificación deleuziana.
Ti esti state-terrorism?
Authors: Aliozi Dr. Zoi
Published: October 2015

Este trabajo aborda la cuestión filosófica y urgente del “ti esti state-terrorism”. El ensayo analiza críticamente y filosóficamente el concepto del terrorismo del estado, basado en una discusión epistemológica, que intenta re-formular la cuestión del terrorismo, donde se argumenta que el terrorismo de estado es el fenómeno inicial y la raíz del terrorismo en todas sus formas. Mi aspiración es contribuir a una comprensión del terrorismo que trate de revelar cómo en griego –el idioma de los conceptos y la filosofía– el término “terrorismo” es “terror-cracia” y significa literalmente el terrorismo del estado; también es parte de la misma familia de la democracia, al tener el sufijo “–cracia.” Este reconocimiento puede revelar nuevas maneras de ver el concepto y fenómeno del terrorismo, o incluso puede ayudar a redefinir el concepto por completo al ponerlo en sintonía con su sentido original. Según este razonamiento, el terrorismo se referiría a una forma del gobierno y a un sistema político. En mi ensayo introduzco esta hipótesis al hilo de diálogos filosóficos sobre el terrorismo, ya que el asunto no se había discutido nunca antes en estos términos. “El terrorismo del estado” es un término prohibido según los expertos jurídicos, pero los pensadores críticos no deben tratarlo como término estéril.
Animal demasiado humano: La influencia de Schopenhauer en la crítica de John Gray al humanismo
Authors: Mateu Alonso Juan David
Published: October 2015

El objetivo de este artículo es analizar la crítica de John Gray al humanismo. Este teórico político ha planteado en algunas de sus obras una fuerte crítica no sólo del liberalismo, sino también de la idea de progreso, los proyectos políticos utópicos y el antropocentrismo. En primer lugar, quisiera esbozar una definición provisional de humanismo y analizar cómo reconstruye Gray este concepto. En segunda instancia, habría que desarrollar las principales críticas que Gray lanza a esta corriente de pensamiento. En este sentido, me gustaría exponer sus influencias, en particular, su referencia a Schopenhauer. Por último, y a modo de conclusión, me gustaría hacer un balance de esta crítica y apuntar algunas de sus posibles limitaciones.
Creer en el mundo, creer en el futuro: Deleuze y la «gran política» del pensamiento
Authors: Canavera Julien
Published: October 2015

El propósito del presente trabajo es mostrar en qué medida la afirmación deleuziana de una unidad compleja entre vida y pensamiento implica, no sólo una crítica radical de (la filosofía de) la trascendencia –y, a su través, de (la metafísica de) la presencia–, sino también una clínica (relativa al pensar, a la sensibilidad, al cuerpo y, por ende, al tiempo) de cuyo desarrollo la «fe» en este mundo (inmanencia), así como la creencia en el porvenir (novación), constituyen las dos principales directrices.
mentira como principio epistemológico
Authors: Ferrer García Alberto
Published: October 2015

La gestión de la existencia pasa por el empleo del mentir como herramienta clave en el uso cotidiano. La «utilidad» que de ello extrae el hombre es de una enorme variedad. Ha sido largo el tiempo en que la mentira ha quedado reducida a un mero problema moral, pero la verdadera cuestión por el mentir estriba en su estatus ontológico. Mentir –más concretamente: mentirse– es un modo de gestionar la peculiar existencia que nos ha sido dada.
Estrategias de inteligibilidad y donación de sentido
Authors: Orozco Pérez Manuel
Published: October 2015

En este trabajo se abordan dos problemas fundamentales que han vertebrado buena parte de la historia de la filosofía: por un lado, las estrategias de inteligibilidad ante lo desconocido e ingobernable; y, por otro lado, el problema de la donación de sentido. Ambos temas se abordan a partir de los análisis de Max Weber sobre la racionalidad moderna. La apuesta metodológica será la del propio Weber: los tipos ideales. Se procederá estableciendo parámetros y criterios en (y partir de) su obra que no tienen por qué darse en la realidad como tales, pero que servirán para tratar la problemática que aquí se plantea.
prometeico de la naturaleza dionisíaco-apolínea en la forma de sentir y pensar de la poesía de Goethe
Authors: Albanese Pastene Francisco , Leal Riquelme Rubén
Published: October 2015

Utilizando el pensamiento expuesto la obra El Origen de la Tragedia, de Friedrich Nietzsche, en particular lo relacionado con los dioses Apolo y Dionisios, se analizan los componentes dionisíacos y apolíneos en la evolución de lo prometeico en la obras poéticas Prometeo, Límites de lo humano, Lo divino y Uno y todo, de Johann Wolfgang von Goethe.
diálogo antisocrático: enseñanza y lenguaje metafórico en los escritos inéditos de Emmanuel Levinas
Authors: Llorente Cardo Jaime
Published: October 2015

Este estudio trata de presentar el modo en el que los escritos inéditos de Levinas abordan la cuestión relativa a la expresión lingüística entendida como apertura a la trascendencia representada por la alteridad del Otro. En particular, se presta atención a las teorías levinasianas acerca de la enseñanza y la naturaleza del Decir metafórico, en tanto que ambos fenómenos reflejan formas privilegiadas de la exterioridad.
Filosofía del aula inteligente del S. XXI: críticas urgentes y necesarias
Authors: Sánchez-Bayón Antonio
Published: October 2015

Este estudio trata el aula inteligente (especialmente, el modelo SEK), evaluándose sus fundamentos filosóficos y educativos, además de profundizar en sus principales problemas y retos actuales, con el tránsito al nuevo estadio de la globalización (globalización 2.0). Se diagnostican los fallos coyunturales y paradigmáticos (desmontándose inferencias, imposturas y falacias), y se pronostica acerca de los riesgos de no tomar medidas correctoras. Se presta especial atención al riesgo Kodack, por el que se está dando más énfasis a la inteligencia artificial en el aula que a la humana. Finalmente, se ofrece una serie de propuestas terapéuticas.
Filosofar con el pulso ardiendo: El trasvase poético de la filosofía de Sánchez Vázquez
Authors: Pérez Trujillo Axel
Published: October 2015

El presente trabajo analiza la base poética de la filosofía de la praxis de Sánchez Vázquez, centrando la atención en cómo su compromiso político halló en la poesía un vehículo de expresión desde un primer momento, si bien más tarde se produjo un trasvase hacia un anclaje más teórico y filosófico.  De ahí que su poesía sea fundamental en la evolución de su pensamiento en el camino hacia conceptos marxistas tales y como la praxis.
Diagnostic use of magnetic resonance imaging (MRI) of a cervical epidural abscess and spondylodiscitis in an infant – case report
Authors: Raus Iulian , Tatar Simona , Coroiu Roxana Elena
Published: October 2015

Epidural abscess in infancy is very rare and has non-specific features, requiring very careful attention and early diagnosis. We present a case of a 3-month-old girl in which the diagnosis of spontaneous cervical epidural abscess developed after an initial episode of acute enterocolitis and was subsequently identified at a later visit to the emergency department for right-upper extremity hypotonia. Endoscopy revealed slightly domed retro pharynx and magnetic resonance imaging (MRI) scan showed cervical spondylodiscitis at the level of intervertebral disc C5-C6 with right-sided epidural abscess that compressed the spinal cord and right C6 nerve root, without extension into superior mediastinum. The systemic antibiotic treatment with meropenem and clindamycin solved the symptoms but the spondylodiscitis complicated with vertebral body fusion which can be symptomatic or not in the future and needs follow-up. Cervical spontaneous spondylodiscitis with abscess is very rare, especially in this age group. This case emphasizes the importance of investigating an upper extremity motor deficiency in infancy and diagnosing any potential spondylodiscitis complication.
BETTER PROGNOSIS IN OVERWEIGHT/OBESE CORONARY HEART DISEASE PATIENTS WITH HIGH PLASMA LEVELS OF LEPTIN
Authors: Vida Simiti Luminita Animarie , Todor Irina , Stoia Mirela Anca , Goidescu Cerasela Mihaela , Anton Florin Petru , Farcas Anca Daniela
Published: October 2015

Background and aim. The involvement of leptin in atherosclerosis is very complex, including inflammation, the oxidative stress and thrombosis. Leptin has atherogenic and also antiatherogenic actions. In obesity elevated leptin levels are not sufficient to prevent disturbances of energy balance, suggesting that obese people are leptin resistant. The aim of the study was to investigate the relationship between baseline plasma levels of leptin and the incidence of new ischemic events in patients with CHD.Methods. Plasma levels of leptin in fifty nine consecutive patients (29 men and 30 women) with CHD hospitalized in the County Emergency Clinical Hospital of Cluj-Napoca were measured using commercially available ELISA at admission. Patients with active infectious disease, neoplasia, acute coronary syndrome, stroke, hepatic or renal failure and severe heart failure were excluded The relationship between leptin levels and incident cardiovascular events (angina, nonfatal myocardial infarction or heart failure) over two years follow-up was studied using  MEDCALC version 9.6.Results. 73.6% patients with CHD were overweight or suffered of obesity. There were no significant differences between women and men regarding the plasma levels of leptin, the body mass index (BMI), the number of rehospitalizations, rehospitalizations/patient, diabetes mellitus, hypertension or dyslipidemia. Only in women plasma levels of leptin are correlated with BMI. As compared with men with overweight and obesity (BMI ≥25kg/m2), plasma levels of leptin were significantly higher in women with overweight and obesity (3905.97±463.91 pg/ml vs 1835.17±533.9 pg/ml) (p<0.002). Patient gender could not be demonstrated to influence prognosis. During the two years we recorded one or more readmissions in 26 patients (44%). The analysis of time till readmission using Kaplan-Meier curves, showed that leptin level (cut-off 2000 pg/ml, HR 0.38, 95% CI 0.17-0.83; p=0.01) and BMI (cut-off 28 kg/m2, HR 0.3164, 95% CI 0.145-0.0689; p<0.01) were significantly associated with prognosis.Conclusion. Patients with plasma levels of leptin >2000 pg/ml and BMI >28kg/m2 had a better prognosis, suggesting a protective role of leptin in overweight/mild obesity.
HUMAN TOOTH AND ROOT CANAL MORPHOLOGY RECONSTRUCTION USING MAGNETIC RESONANCE IMAGING
Authors: Dragăn Oana Carmen , Fărcășanu Alexandru Ștefan , Câmpian Radu Septimiu , Turcu Romulus Valeriu Flaviu
Published: October 2015

Background and aims. Visualization of the internal and external root canal morphology is very important for a successful endodontic treatment; however, it seems to be difficult considering the small size of the tooth and the complexity of the root canal system. Film-based or digital conventional radiographic techniques as well as cone beam computed tomography provide limited information on the dental pulp anatomy or have harmful effects. A new non-invasive diagnosis tool is magnetic resonance imaging, due to its ability of imaging both hard and soft tissues. The aim of this study was to demonstrate magnetic resonance imaging to be a useful tool for imaging the anatomic conditions of the external and internal root canal morphology for endodontic purposes.Methods. The endodontic system of one freshly extracted wisdom tooth, chosen for its well-known anatomical variations, was mechanically shaped using a hybrid technique. After its preparation, the tooth was immersed into a recipient with saline solution and magnetic resonance imaged immediately. A Bruker Biospec magnetic resonance imaging scanner operated at 7.04 Tesla and based on Avance III radio frequency technology was used. InVesalius software was employed for the 3D reconstruction of the tooth scanned volume.Results. The current ex-vivo experiment shows the accurate 3D volume rendered reconstruction of the internal and external morphology of a human extracted and endodontically treated tooth using a dataset of images acquired by magnetic resonance imaging. The external lingual and vestibular views of the tooth as well as the occlusal view of the pulp chamber, the access cavity, the distal canal opening on the pulp chamber floor, the coronal third of the root canals, the degree of root separation and the apical fusion of the two mesial roots, details of the apical region, root canal curvatures, furcal region and interradicular root grooves could be clearly bordered.Conclusions. Magnetic resonance imaging offers 3D image datasets with more information than the conventional radiographic techniques. Due to its ability of imaging both hard and soft dental tissues, magnetic resonance imaging can be successfully used as a 3D diagnostic imaging technique in dentistry. When choosing the imaging method, dental clinicians should weight the benefit-risk ratio, taking into account the costs associated to magnetic resonance imaging and the harmful effects of ionizing radiations when cone beam computed tomography or conventional x-ray are used.
Effects of sleeve gastrectomy on insulin resistance
Authors: Cătoi Adriana Florinela , Pârvu Alina , Mironiuc Aurel , Galea Romeo Florin , Mureşan Adriana , Bidian Cristina , Pop Ioana
Published: October 2015

Background and aim. Obesity is a major risk factor for the onset of insulin resistance (IR), hyperinsulinemia and type 2 diabetes mellitus (T2DM) Evidence data has proven that beyond important weight loss bariatric surgery especially Roux-en-Y gastric bypass (RYGB) and bilio-pancreatic diversion (BPD) leads to significant early reduction of insulinemia and of IR calculated through the homeostatic model assessment (HOMA-IR), independently of fat mass decrease. Sleeve gastrectomy (SG) is now used as a sole weight loss operation with good results. Therefore, the aim of the present study was to investigate the early changes of fasting blood glucose, insulin and HOMA-IR in a group of morbidly obese (MO) patients i.e. at 7, 30 and 90 days after SG. Methods. The study included 20 MO patients (7 male and 13 female) submitted to SG. Anthropometrical (weight, body mass index –BMI, percent excess BMI loss -%EBMIL) and biochemical (plasma glucose, insulin and calculated HOMA-IR ) evaluation were performed before and at 7, 30 and 90 days after SG. In addition, a second group of 10 normal weight healthy subjects with a BMI ranging form 19 kg/m² to 23.14 kg/m², matched for age and gender was investigated. Results. Plasma glucose (p=0.018), insulin (p=0.004) and HOMA-IR (p=0.006) values were statistically different between the studied groups. After surgery, at every follow-up point, there were statistically different weight and BMI mean values relative to the operation day (p<0.003). BMI, decreased at 7 days (estimated reduction=2.79; 95% CI:[2.12;3.45]), at 30 days (estimated reduction=5.65; 95% CI:[3.57;7.73]) and at 90 days (estimated reduction=10.88; 95% CI:[7.35;14.41]) respectively after SG. We noted a tendency toward statistical significant change of mean insulin values at 7 days after surgery (corrected p=0.075), no statistical change at 30 days (corrected p=0.327) and a significant change at 90 days (corrected p=0.027) after SG as compared to baseline. There was a significant change in mean values of HOMA-IR at 30 days (corrected p=0.009) and at 90 days (corrected p=0.021) after the operation day. Conclusions. The present study showed important early changes consisting in reductions of mean values of plasma insulin and HOMA-IR after SG.
PERFORMANCE ASSESMENT OF THE RESEARCH: BIBLIOMETRICS
Authors: Kolesnykova T. O. , Matveyeva O. V.
Published: October 2015

Purpose. Key performance indicators of the research are bibliometric ones which are a powerful informative tool to support the development of science. Therefore, nowadays in the world they are related to the obligatory elements in reporting of scientific institutions, universities, research groups and individual scientists. Based on the above stated, the purpose of the article is: 1) disclosure of concepts in bibliometrics; 2) definition the role of university libraries in the processes of University research measuring; 3) description the program Bibexel methodology for the analysis of the scientific articles metadata. Methodology. The theoretical base of the research is publications covering contemporary developments in bibliometrics and scientometrics. Practical foundation – the metadata of articles posted in: 1) Scopus database, authors are the scientists of the Dnipropetrovsk National University of Railway Transport named after Academician V. Lazaryan, 2) ScienceDirect database, dedicated to the development of railway transport. Findings. In the course of the study authors have disclosed principal bibliometric concepts. A Bibexel program method for analyzing metadata, namely analysis of the links between co-authors and keyword was described. With its help it was determined that the most «top» topics for researchers all over the world, in the field of railway transport in 2015 year are: planning a high-speed movement, the critical speed definition, computer calculation of railway bridges. It was proved that today the work of University libraries in the world with bibliometric indicators as an indicators of the science development, becomes one of the leading direction of their activity. Originality. The authors substantiated and realized the bibliometric researchability, using Bibexel program in the conditions of limited access at the university libraries in Ukraine to international full-text databases and Science Citation one. Vision about the University library as a structure that moves up from the management by scientific collections to the management by scientific processes was broadened. Practical value. The results of this study can be used: 1) in making the optimal decision upon managing the information resources in order to improve the processes of information application and services, including scientific impact assessment of scientists publications and scientific journals of the Universities; 2) in the organization of training seminars, training courses, workshops, informetrics lectures.
FEATURES OF THE RESEARCH WORK ELEMENTS DEFORMABILITY OF RAILWAY TRACK
Authors: Bondarenko I. O.
Published: October 2015

Purpose. The scientific paper is supposed the determination of basic physical and structural conditions in modeling life cycle of the elements of the railway line for the study of deformation processes as the basis of normative base of the track at the condition of railway safety. Methodology. To achieve the aim principles of the elasticity theory and wave propagation process in the description of the interaction between the track and rolling stock were used. Findings. The basic physical and structural conditions under which it is necessary to carry out the simulation of the life cycle of the elements of the railway line for the study of deformation processes were determined. The basic physical and structural principles of drawing the design schemes of railway track elements for the process assessment of the track deformation work were formulated. The decision correctness and the possibility of the problem solution are proved. Originality. The study of the track reliability questions motivates the development of new models, allow considering it for some developments. There is a need to identify the main physical and structural conditions for assembly design schemes based on assessment and prediction of possible track state changes during its operation. The paper presents the basic principles of physical and structural drafting design schemes of railway line items for which Huygens’ principle is implemented. This principle can be performed only when the four dimensional space: the volume changing over time is considered. Practical value. Analytical models applied in determining the parameters of strength and resistance lines, fully satisfy the task, but can not be used to determine the parameters of track reliability. One of the main impossibility factors of these models is quasidynamic approach. Therefore, as a rule, receive and examine not only dynamic process of a railway track, but also its consequences. Besides, these models are related to flat ones, and it also adds some complexity in results comparing with an experiment, as well as the process is not easy to distinguish the impact of volume in its limited parts. The use of numerical methods extend the posibilities, and it also make it impossible for the consideration of the dynamic process, as well as it is impossible to introduce processes, causing the reaction to stress load. Thus the basic physical and constructive approaches in modeling make it possible to consider the dynamic process of localized both in time and in space directly.
SOME ASPECTS OF THE DEFINITION OF EMPTY CARS STABILITY FROM SQUEEZING THEIR LONGITUDINAL FORCES IN THE FREIGHT TRAIN
Authors: Shvets A. O. , Zhelieznov K. I. , Akulov A. S. , Zabolotnyi O. M. , Chabaniuk E. V.
Published: October 2015

Purpose. Despite of the implementation various programs to improve the safety of train traffic problem of reducing gatherings rolling stock off the rails is still relevant. The study aims to clarify the existing method of determining the factor of stability from the tire longitudinal forces to ensure the sustainability of cars with increasing speeds of the rolling stock. Methodology. Research was conducted by the method of mathematical modeling of loading freight car when driving at different speeds on straight and curved track sections. Findings. Analysis of the results shows that, for all selected freight cars for the calculation, the value of the safety factor by squeezing is smaller than the formulas of Standards. Corrections made to the formula for determining the safety factor by squeezing longitudinal forces, would achieve: 1) a higher safety factor of lightweight cars, excluding them squeezing longitudinal forces in the entire range of speeds of freight trains; 2) to develop and implement measures to prevent squeezing of cars in the entire range of motion; 3) to determine the degree of stability of the empty car in the head, middle and tail laden trains; 4) to offer optimal scheme of mixed trains formation. Originality. The analysis of existing methods for determining stability coefficient cars in freight trains from squeezing their longitudinal forces is presented in studies. Proposals are developed for the refinement of the design phase, construction and operation. Practical value. This study clarifies the existing method of determining the safety factor of stability from the squeezing longitudinal forces, as well as the influence on the magnitude of the coefficient of speed of movement of the rolling stock. Developed proposals for the refinement of existing methods for determining stability coefficient of longitudinal forces squeezing cars in a train, can reduce the number of retirements cars derailed by taking into account in the calculation and design of important parameters and characteristics that increase their stability in the rail track especially with increasing speeds of freight traffic.