bluuebunny/crossref_metadata_2025 huggingface dataset:
Rehabilitasi spiritualitas Islam untuk pencandu narkoba di pondok rehabilitasi tetirah dzikir
Authors: Wulandari Erni , Wardana Amika
Published: September 2024

Penelitian mendalami metode rehabilitasi pecandu narkoba berbasis spiritualitas Islam yang dikembangkan di Pondok Rehabilitasi Tetirah Dzikir yang berlokasi di Berbah, Sleman, Yogyakarta. Data penelitian dikumpupulkan melalui wawancara kualitatif bersama pengurus dan pengelola pondok dan observasi langsung di lokasi; yang dianalisis untuk menjawab pertanyaan utama. Hasil penelitian menyatakan serangkaian aktifitas spiritualitas Islam dalam tradisi tarekat Qadiriyah wa Naqsyabandiyah yang dikembangkan untuk program rehabilitasi pecandu narkoba, meliputi: khalwat, mandi taubat, sholat wajib dan sunnah, dzikir rutin, talqin dzikir (managib), puasa dan kegiatan sosial kemasyarakatan. Kombinasi antara disiplin diri, ritual tarekat, kebersamaan di pondok dan partisipasi dalam kegiatan sosial-kemasyarakatan membantu proses rehabilitasi pecandu narkoba.
Perempuan dalam pemberdayaan sosial di Komunitas Pelangi Nusantara Malang
Authors: Sartika Emilia Nanda , Widianto Ahmad Arif
Published: September 2024

Penelitian mengkaji bentuk partisipasi perempuan dalam pemberdayan sosial di Komunitas Pelangi Nusantara Malang (Pelanusa). Penelitian menggunakan metode kualitatif melibatkan founder, pembina, ketua tim kreatif, anggota tim kreatif, dan anggota binaan di Pelanusa. Hasil penelitian menunjukkan partisipasi aktif peserta perempuan dalam kegiatan kewirausahaan sosial dan pendampingan pada program pelatihan pembuatan produk kerajinan pembekalan kewirausahaan. Namun, disamping keterbatasan sumber daya di Pelanusa, kemauan dan kemampuan dasar peserta perempuan sedikit banyak menghambat partisipasi aktif mereka. Selain itu, beberapa peserta tidak mendapat dukungan penuh dari keluarga termasuk tidak sepernuhnya diizinkan oleh suami untuk terlibat di Pelanusa.
Cancel culture pelaku pelecehan seksual di media sosial
Authors: Hasna Asyifa Amalia , Hendratomo Grendi
Published: September 2024

Penelitian mengivestigasi cancel culture pelaku pelecehan seksual di media sosial sebagai salah satu respon terhadap penanganan kasus pelecehan seksual di Indonesia yang belum maksimal. Dengan keterbatasan pemahaman dan pengetahuan masyarakat tentang perilaku jahat dan juga tentang cancel culture, sehingga masih pro-kontra marak dalam masyarakat.  Hasil penelitian menunjukkan cancel culture dimaknai sebagai bentuk boikot dan pemberhentian karir seseorang karena dianggap melanggar nilai dan norma masyarakat dan meningkatkan kesadaran dan kewaspadaan terkait isu pelecehan seksual. Namun terdapat relasi kuasa oleh pelaku pelecehan seksual yang memiliki status sosial tinggi sehingga mempengaruhi dampak maupun keberhasilan dari cancel culture itu sendiri. Gerakan cancel culture belum sepenuhnya efektif diberlakukan untuk melawan pelecehan seksual karena khalayak tidak sepenuhnya memahami cancel culture dan masih kuatnya budaya patriakhi dalam masyarakat Indonesia.  Research investigates the cancel culture of sexual harassment perpetrators on social media as a response to the inadequate handling of sexual harassment cases in Indonesia. With limited public understanding and knowledge about evil behavior and also about cancel culture, pros and cons are still widespread in society. The research results show that cancel culture is interpreted as a form of boycott and termination of a person's career because it is deemed to violate societal values and norms and increases awareness and vigilance regarding the issue of sexual harassment. However, there are power relations between perpetrators of sexual harassment who have high social status, which influences the impact and success of cancel culture itself. The cancel culture movement has not been fully effective in fighting sexual harassment because the public does not fully understand cancel culture and the strong patriarchal culture in Indonesian society.
Asimilasi sosial-budaya mahasiswa Papua di IAIN Kudus
Authors: Wahayuningtiyas Ainun , Fiani Destina Marta , Rizqina Yusrotin Meila , Zuhaida Fainanu , Fathoni Irfan , Fatah Ahmad
Published: September 2024

Mahasiswa berasal dari Papua – karena perbedaan budaya, kehidupan sosial dan pengalaman pendidikannya – menghadapi tantangan yang tidak mudah untuk beradaptasi seiring menyelesaikan studinya tingkat universitas. Dengan melakukan wawancara mahasiswa-mahasiswa Papua di IAIN Kudus Jawa Tengah, penelitian menelaah berbagai tantangan yang mereka hadapi dalam kehidupan sosial di dalam dan di luar kampus sekaligus berbagai strategi mengatasinya dan menyelesiakan studinya. Hasil penelitian menunjukkan upaya dan strategi mahasiswa Papua dengan menjalin pertemanan dengan orang lokal dan belajar bahasa lokal agar dapat berinteraksi serta mengikuti berbagai organisasi baik intra kampus maupun luar kampus untuk menambah relasi. Proses adaptasi yang dijalani menunjukkan pola asimilasi sosial-budaya yang dilakukan dalam kehidupan dalam dan luar kampus oleh mahasiswa Papua di IAIN Kudus.Students from Papua – due to differences in culture, social life, and educational experiences – face challenges that are not easy to adapt to as they complete their university studies. By conducting interviews with Papuan students at IAIN Kudus, Central Java, the study examines the various challenges they face in their social life on and off campus as well as various strategies to overcome them and complete their studies. The results of the study show the efforts and strategies of Papuan students by making friends with local people and learning the local language so they can interact and join various organizations both intra-campus and off-campus to expand their relationships. The adaptation process that is undergone shows a pattern of socio-cultural assimilation carried out in life on and off campus by Papuan students at IAIN Kudus.
The influence of auditor ethics on audit quality: Analyzing key factors in Vietnamese audit firms
Authors:   Faculty of Business and Economics, Phenikaa University, Yen Nghia, Ha Dong, Hanoi 12116, Vietnam, Nguyen Thi Thuan , Nguyen Hoang Lan ,   Faculty of Business and Economics, Phenikaa University, Yen Nghia, Ha Dong, Hanoi 12116, Vietnam, Le Tuyet Nhung ,   Faculty of Business and Economics, Phenikaa University, Yen Nghia, Ha Dong, Hanoi 12116, Vietnam, Tran Nguyen Bich Hien ,   Faculty of Accounting and Auditing, Thuongmai University, Hanoi, Vietnam
Published: September 2024

This paper aims to analyze the possible influence of auditor ethics (AE) factors on audit quality (AQ). Additionally, this study examines whether AE can mediate the relationship between various factors and AQ. These factors include independence, competence, work experience, ethical standards, and due care. Data were collected using structured questionnaires sent by post or email to auditors, audit team leaders, and deputy managers/heads of 314 independent audit firms in Vietnam. Using SPSS 26 and AMOS 24 for analysis, the results show positive relationships between competence, work experience, ethical standards, and AE, as well as between competence, due care, and AQ. Negative relationships were found between independence, due care, and AE and between independence, work experience, ethical standards, and AQ. These findings provide important recommendations for auditing companies to enhance ethics and AQ, helping them maintain loyal customers, attract potential clients, and further develop audit services in Vietnam.
Entrepreneurial ecosystem and intentions of students in multidisciplinary universities: A study in Can Tho, Mekong Delta, Vietnam
Authors:   Business Administration, Bac Lieu University, Bac Lieu City, Vietnam, Dan Phan Van , Duyen Chau Thi Le ,   Business Administration, School of Economics, Can Tho University, Can Tho City, Vietnam, Khang Ma Vinh ,   Business Administration, School of Economics, Can Tho University, Can Tho City, Vietnam, Tu Phan Anh ,   Business Administration, School of Economics, Can Tho University, Can Tho City, Vietnam, Binh Huynh Van ,   Business Administration, School of Economics, Can Tho University, Can Tho City, Vietnam
Published: September 2024

This study used both qualitative and quantitative research methods, surveying 325 respondents. Initially, the research model included seven factors that could influence students' entrepreneurial intentions: university, government, support organizations, funding providers, research organizations, large enterprises, and service providers. The results from the multivariate regression analysis identified four significant factors: universities, funding providers, research organizations, and large enterprises. The study also found that three variables—government, support organizations, and service providers—were not statistically significant. In conclusion, the key factors within the entrepreneurial ecosystem of multidisciplinary universities that influence students' entrepreneurial intentions are the university, funding providers, research organizations, and large enterprises.
Taking India to the World in Higher Education: The Case of an Indian University as PRME Champion
Authors: Bhattacharjee Anindo , Chepuri Pavana Kiranmai
Published: September 2024

This paper talks about the importance of leadership in higher education based on an autoethnographic study conducted by the authors. The paper presents the case study of a young Indian multidisciplinary university to show the importance of higher education leadership to achieve the SDGs through focus on responsible management education. The paper provides a 4I framework for SDG integration into management education through effective higher education leadership based on the values given in our Indian Knowledge Systems. Finally, the paper concludes showing the paradigm shift needed in internationalization of higher education institutions and the importance of implementing the PRME principles for achievement of the SDGs in higher education
Social Currency, Strategies and Consumer Behavior in Post-pandemic World
Authors: Singh Anurag
Published: September 2024

The adverse effects of the pandemic forced people to keep distance from each other, driving them to use social media for communication and shopping. The behavior emerged due to pandemic has now altered buying behaviors in new normal. The buyers have used social media to express themselves in the online community in addition to purchasing. The social currency, which is the shared experience and expression in the social community has played an important role. In order to focus on the three research questions, this study explored the literature sources including research journals, corporate house reports and news published in magazines. Following quantitative sequential design, the study used the blend of convenience and purposive sampling technique to explore research papers through Google Scholar. The study found 57 research papers suitable for approaching narrative literature review. This paper discusses the different dimensions of social currency as well as their role in the communication that takes place via social media. These explanations were made in reference to consumer behavior that was developed during the pandemic and their reflection in the period after the pandemic. With the assistance of various anecdotal evidence, this paper has provided additional commentary on the ways in which social currency on social media can improve consumer behavior in a world that has been affected by a pandemic. This paper significantly improves theoretical and practical knowledge on the dimensions of social currency and the gives the picture that how the social currency can be used to improve performance of the brands in the changed consumer behavior of new normal. The study also explained the limitations and proposed future research direction at the end.
Organizational Schizophrenia: Towards a Conceptualization and Scale Development
Authors: Sinha Ashish , Gautam Deepansha , Pandey Amitabh
Published: September 2024

Organizations today are facing a lot of external turbulence and internal turbulence. Central to these problems is the people working in organizations and their problems. One of the problems that is of great importance but less talked about is organizational schizophrenia. It is a corollary drawn from the term “schizophrenia” of clinical psychology which is a psychological disorder. Many of its characteristics apply to organizations as well such as lack of alignment of policies and goals of the organization, double bind paradox, reality detachment and so on. Psychosis in organizations has been well studied and established. It is imperative to mitigate this psychotic problem in organizations before it assumes menacing proportions. But mitigation requires measurement. A four-factor scale consisting of 19 items which can measure the extent of organizational schizophrenia has been developed in this paper. Some of the challenging issues/ factors responsible for creating a schizophrenic organization were found to be confusion in corporate policies, leadership behavior, work environment and culture, trust, support and employee engagement.
Obtención de un nuevo cultivar de cacao (Theobroma cacao L.) en Colombia “CNCH 12”
Authors: Gil Alejandro , Jaimes Alexander , Vega Fabio N. , Martinez Heli , Bautista Hernando , Urrego Jhorman E. , Calderón Becerra Luis Eduardo , Hincapié Óscar D. , Hernández Pablo E. , Restrepo Quiroz Tatiana Inés , Ardila Diaz Nelson
Published: September 2024

El cultivo de cacao juega un papel importante en el desarrollo rural colombiano. Además de ser identificado como un potencial sustituto de cultivos ilícitos, el cacao brinda sustento a unas 65,000 familias en Colombia. No obstante, la baja productividad del cultivo indica que su potencial es aún limitado. El objetivo de esta investigación fue el de evaluar el genotipo de cacao CNCh12, previamente seleccionado en el programa de mejoramiento genético con el que cuenta la Compañía Nacional de Chocolates y compararlo con un testigo comercial, el clon CCN51. Para ambos materiales se evaluaron las variables de interés como son: productividad (Kg/Ha/Año), compatibilidad sexual, resistencia a M. roreri, características físicas, químicas y funcionales del grano y parámetros morfológicos y perfil sensorial del licor de cacao. Los resultados indican que el cultivar CNCh12 es altamente productivo, autocompatible y moderadamente resistente a la Moniliasis. Este genotipo presenta además características de interés que permiten satisfacer las demandas para la industria chocolatera por sus atributos físicos, químicos y funcionales, asimismo, por su calidad sensorial fina en sabor y aroma. De esta manera Compañía Nacional de Chocolates se consolida como la primera empresa privada en desarrollar materiales vegetales avalados en el Registro Nacional de Cultivares Comerciales del Instituto colombiano agropecuario-ICA, fortaleciendo así la diversidad genética que posee el país.
The Validity of Impressions as a Media Dose Metric in a Tobacco Public Education Campaign Evaluation: Observational Study
Authors: Davis Kevin , Curry Laurel , Bradfield Brian , Stupplebeen David A , Williams Rebecca J , Soria Sandra , Lautsch Julie
Published: September 2024

Background

Evaluation research increasingly needs alternatives to target or gross rating points to comprehensively measure total exposure to modern multichannel public education campaigns that use multiple channels, including TV, radio, digital video, and paid social media, among others. Ratings data typically only capture delivery of broadcast media (TV and radio) and excludes other channels. Studies are needed to validate objective cross-channel metrics such as impressions against self-reported exposure to campaign messages.

Objective

This study aimed to examine whether higher a volume of total media campaign impressions is predictive of individual-level self-reported campaign exposure in California.

Methods

We analyzed over 3 years of advertisement impressions from the California Tobacco Prevention Program’s statewide tobacco education campaigns from August 2019 through December 2022. Impressions data varied across designated market areas (DMAs) and across time. These data were merged to individual respondents from 45 waves of panel survey data of Californians aged 18-55 years (N=151,649). Impressions were merged to respondents based on respondents’ DMAs and time of survey completion. We used logistic regression to estimate the odds of respondents’ campaign recall as a function of cumulative and past 3-month impressions delivered to each respondent’s DMA.

Results

Cumulative impressions were positively and significantly associated with recall of each of the Flavors Hook Kids (odds ratio [OR] 1.15, P<.001), Dark Balloons and Apartment (OR 1.20, P<.001), We Are Not Profit (OR 1.36, P<.001), Tell Your Story (E-cigarette, or Vaping, product use Associated Lung Injury; OR 1.06, P<.05), and Thrown Away and Little Big Lies (OR 1.05, P<.01) campaigns. Impressions delivered in the past 3 months were associated with recall of the Flavors Hook Kids (OR 1.13, P<.001), Dark Balloons and Apartment (OR 1.08, P<.001), We Are Not Profit (OR 1.14, P<.001), and Thrown Away and Little Big Lies (OR 1.04, P<.001) campaigns. Past 3-month impressions were not significantly associated with Tell Your Story campaign recall. Overall, magnitudes of these associations were greater for cumulative impressions. We visualize recall based on postestimation predicted values from our multivariate logistic regression models.

Conclusions

Variation in cumulative impressions for California Tobacco Prevention Program’s long-term multichannel tobacco education campaign is predictive of increased self-reported campaign recall, suggesting that impressions may be a valid proxy for potential campaign exposure. The use of impressions for purposes of evaluating public education campaigns may help address current methodological limitations arising from the fragmented nature of modern multichannel media campaigns.
The Utility and Implications of Ambient Scribes in Primary Care
Authors: Seth Puneet , Carretas Romina , Rudzicz Frank
Published: September 2024

Ambient scribe technology, utilizing large language models, represents an opportunity for addressing several current pain points in the delivery of primary care. We explore the evolution of ambient scribes and their current use in primary care. We discuss the suitability of primary care for ambient scribe integration, considering the varied nature of patient presentations and the emphasis on comprehensive care. We also propose the stages of maturation in the use of ambient scribes in primary care and their impact on care delivery. Finally, we call for focused research on safety, bias, patient impact, and privacy in ambient scribe technology, emphasizing the need for early training and education of health care providers in artificial intelligence and digital health tools.
Safety climate and work stress in university administration staff
Authors: Yunus Shalsabilla , Doda Diana Vanda Daturara , Maino Irny Evita
Published: September 2024

Purpose: Workers can be exposed to work stress that can cause accidents. As a center for the development of science, universities cannot avoid the dangers and risks that can threaten safety. In this case, there is a need for an approach to workplace safety through applying a safety climate that is useful for providing a sense of security and comfort and increasing safety behavior.
Method: This survey used 164 respondents who work at a university, asking questions about gender, age, work experience, stress level, and perception of safety. The analysis included univariate analysis using frequency and percentage; bivariate and multivariate analysis using a binary logistic regression test.
Result: Most respondents were women, middle-aged, and had worked for more than 21 years. More than half of the respondents experienced stress and rated the safety climate as low. Male respondents had a higher chance of experiencing stress than female respondents. Respondents with a lower level of safety climate were more likely to report work stress than those respondents with a high level of safety climate.
Conclusion: Respondents’ perception of the safety climate affected their stress levels, and managers should consider this when designing programs to prevent stress at work.
Nonprescription antimicrobial use during the COVID-19 pandemic: a systematic review
Authors: Karolina Sinta , Sulistiadi Wahyu
Published: September 2024

Purpose: Restrictions on mobility, confusion of information, and the lack of scientific evidence related to the treatment of COVID-19 have implications for the emergence of self-medication behavior in the community, especially the use of antimicrobials without a prescription. This study aims to describe the pattern of non-prescription antimicrobial use during the COVID-19 pandemic.
Methods:  A systematic review was conducted on articles published between 2020-2022 from 3 databases: Embase, Scopus, and Science Direct, examining the use of over-the-counter antimicrobials during the COVID-19 pandemic. 
Results:  13 relevant studies reviewed usage patterns, including self-medication behavior and antimicrobial dispensing practices without a prescription.
Conclusion: The panic during the COVID-19 pandemic triggered the over-the-counter use of antimicrobials without a prescription, both as an effort to prevent and reduce symptoms. The role of community pharmacists and the government is urgently needed to overcome this.
Community perception of biocontrol agent using Betta splendens (Ikan Cupang) against Aedes aegypti larvae: a community study in Bali
Authors: Sudiartawan I Putu , Erjana I Gede Putra , Juliasih Ni Ketut Ayu , Arsana I Nyoman
Published: September 2024

Purpose: This study attempted to analyze the predation ability of Betta splendens as a biocontrol of Aedes aegypti larvae with a case study in Kartika Neighborhood, Dauh Puri, Denpasar City.
Methods:  This study employed a quasi-experimental approach and a qualitative investigation to ascertain public perceptions of using Betta splendens as a biocontrol agent for Aedes aegypti larvae. The trial lasted one month. Betta splendens were added to the respondent's bath (n=30), and larval mortality was determined at 2, 4, 6, 8, and 10 hours. Analysis of data using the paired t-test.
Results:  The results showed that the characteristics of respondents were dominated by being 18–45 years old (73.30%), being male (56.70%), having a dominant education level of high school (66.60%), and using a cement bathtub (53.30%). The comparative test results obtained a p-value of 0.0001 (p<0.05), indicating a very significant change in the number of Aedes aegypti larvae during bathing before and after adding Betta fish, with an average predation ability of 85.87%. Community perception regarding using Betta fish as a biocontrol agent is very positive, and the acceptance rate and sustainability of Betta fish use reached 96.67%. There is no change in water conditions due to aroma, color, and taste.
Conclusion: The predation power of Betta splendens as a natural biocontrol is excellent and effectively utilized in minimizing the presence of Aedes aegypti larvae in the bath (container).
VALIDATED REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE ESTIMATION OF TETRABENAZINE IN SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEMS
Authors: SHASHI  , PANDEY NARENDRA KUMAR , KUMAR BIMLESH , SINGH SACHIN KUMAR , BAGHEL DILEEP SINGH , SUDHAKAR KALVATALA , SINGH SAURABH
Published: September 2024

Objective: Self-Nano-Emulsifying Drug Delivery System (SNEDDS) of tetrabenazine (TBZ) was analysed using reverse-phase high-performance liquid chromatography.
Methods: Optimized chromatographic condition was consisted of Acetonitrile (ACN) and 0.1% v/v formic acid in the ratio of 90:10 as a mobile phase in isocratic mode at 25±1 °C. In this C-18 (250 mm×4.6 mm, 5 µm) column was used and absorbance was recorded at 283 nm.
Results: The compound was eluted at a flow rate of 1.0 ml/min and retention time (RT) was observed as 4.34±0.03 min. TBZ showed linearity over 2-10 µg/ml conc. and the value of regression was obtained as 0.9992. The developed method was found precise due to Percentage Relative Standard Deviation (%RSD) was less than 2 %. On the other hand, 0.31 and 0.96 were investigated value for Limit of Detection (LOD) and Limit of Quantification (LOQ), respectively.
Conclusion: The method adopted was found to be robust and can be apply for the determination of drug in different oil, surfactants and co-surfactants for the calculation of drug loading of pharmaceutical product formulation.
BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FINASTERIDE, TADALAFIL, AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN RAT PLASMA BY USING LC-MS/MS
Authors: RAYINUTHALA YESUPADAMU , MEDEPALLI DAVID RAJU , LAKSHMANARAO A.
Published: September 2024

Objective: An easy, quick, precise, active and reproducible LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometry) technique was developed for the bio-analytical method of Finasteride and Tadalafil using Avanafil as internal standard (IS).
Methods: This article summarizes the recent progress on bioanalytical liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) methods using waters Symmetry C18 column (150x4.6 mm, 3.5µ) column and mobile phase of 0.1% Perchloric acid and Acetonitrile (ACN) in 60:40.
Results: The calibration curve was linear in the range of 12.5-100 ng/ml for Finasteride and 12.5-100 ng/ml Tadalafil. The recovery results of Accuracy and Precision of Finasteride and Tadalafil were 95.10, 96.85, 98.76, 98.81% and 95.77, 97.46, 97.99, 97.01% at different QC (Quality Control) concentration levels. Matrix effect results were within the acceptable limit. An electro-spray ionization source was used to study of Finasteride and Tadalafil at m/z 373.5497→142.0085, m/z 390.4047→128.1138 for Finasteride and Tadalafil, m/z 484.9516→104.5326 for Avanafil were ion pairs of mass analysis.
Conclusion: The application denotes all the parameters of system suitability, specificity, linearity and accuracy are in good agreement with USFDA (United States of Food and Drug Administration) guidelines and applied effectively for the investigation of pharmacokinetic studies in rat.
COMPUTATIONAL ASSESSMENT OF UNDARIA PINNATIFIDA AND MORINGA OLEIFERA COMPOUNDS AS ANTI-OBESITY AGENTS
Authors: YOGINI C. SAI KALYANI , KUMAR CHITTA SURESH , ANURADHA C. M. , CHITTURI C. H. M. KUMARI
Published: September 2024

Objective: The objective of this topic is to discuss the potential of using bioactive substances of Undaria Pinnatifida Ethanolic Extract of (UPEE) and Moringa Oleifera Methanolic Extract of (MOME) extracts as pharmacological agents and inhibitors of Peroxisome Proliferator-Activated Receptor gamma (PPAR-γ), Fat Mass and Obesity-Associated (FTO), Resistin and leptin to counter obesity.
Methods: The study uses Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-Transform InfraRed (FTIR) Spectroscopy techniques to identify the bioactive components of these extracts and evaluates their efficacy through in silico assessments and molecular docking analysis.
Results: Analysis of docking results revealed that ligand interaction with FTO (ID: 3LFM) docking complex showed good binding affinity, binding oreintation, pharmocological properties. Hence, the best ligands were proposed as the best antagonist to block PPAR-γ, FTO, Resistin and leptin, which plays major role in the drug devolopment pathways.
Conclusion: UPEE and MOME extracts acts as pharmacological agents for anti-obesity genes. PPAR-γ-4CI5 has a best docking score (-7.716 kcal/mol), as a result. As a result, the standard was recommended as the best antagonist to block the key enzyme involved in the drug development pathways.
EVALUATION OF POPULATION PHARMACOKINETICS OF ORAL DIGOXIN IN VENOUS PLASMA
Authors: MAHABOOB SIRAJUDEEN , K. P. ARUN , RAJENDRAN S. D. , GANESH GNK
Published: September 2024

Objective: Digoxin, a cardiac glycoside with extensive clinical usage, poses challenges due to its narrow therapeutic index and wide interindividual variability. Population pharmacokinetic studies in healthy individuals are scarce despite their importance in understanding drug kinetics. This study aimed to characterize the population pharmacokinetics of oral digoxin in healthy volunteers.
Methods: An open-label, single-dose pharmacokinetic study was conducted in 72 healthy Indian adults using digoxin tablets. Plasma samples were collected at various time points, and digoxin concentrations were quantified using Liquid Chromatography-Mass Spectrometry (LC-MS). Population pharmacokinetic analysis was performed using PUMAS® software, incorporating covariates such as creatinine clearance.
Results: The two-compartment model best described the data, with a population estimate of clearance (CL/F) of 12.08 l/h in the base model and 8.3 l/h in the final model. Creatinine clearance significantly influenced digoxin clearance. Goodness-of-fit plots indicated model appropriateness, and Monte Carlo simulation validated model performance.
Conclusion: This study presents a novel population pharmacokinetic model for oral digoxin in healthy individuals. The model accurately predicts digoxin pharmacokinetics and can guide dosage regimen optimization for better therapeutic outcomes. Further research should explore drug interactions and validate the model in diverse populations.
UNLOCKING THE POTENTIAL: ENHANCING SOLUBILITY AND BIOAVAILABILITY OF ACYCLOVIR THROUGH SOLID DISPERSION FORMULATIONS
Authors: MALKAWI RUBA , AL-OLIMAT SULEIMAN , TAWALBEH JUMANA
Published: September 2024

Objective: This study aimed to formulate and evaluate solid dispersions of acyclovir using Polyethylene Glycol (PEG) polymers (PEG 3350, PEG 4000, and PEG 6000) in varying ratios to improve their oral bioavailability.
Methods: Solid dispersions of acyclovir with PEG 3350, PEG 4000, and PEG 6000 were prepared at different weight ratios (1:5, 1:20, and 5:1) using the solvent evaporation method. Physical mixtures were also prepared for comparison purposes. Characterization involved Differential Scanning Calorimetry (DSC) to study thermal behavior, X-ray powder Diffraction (XRPD) to assess the crystalline state, Fourier Transform Infrared Spectroscopy (FTIR) for molecular interactions, and dissolution studies using USP apparatus type 2 to evaluate drug release profiles.
Results: Among the tested formulations, the solid dispersion of acyclovir with PEG 4000 at a 20:1 ratio demonstrated the most favourable dissolution profile, with over 50% drug release within the first 10 min. DSC analysis indicated a significant reduction in the crystallinity of acyclovir within the solid dispersions, particularly with PEG 4000. XRPD confirmed the transformation of acyclovir to an amorphous state, while FTIR spectroscopy revealed molecular interactions between acyclovir and PEG, indicative of enhanced solubility. Dissolution studies further corroborated the superior performance of the 20:1 PEG 4000 formulation, which showed a remarkable increase in solubility compared to other ratios and physical mixtures. Mathematical modeling using the Weibull and Logistic models suggested controlled and predictable release kinetics for the optimized formulation.
Conclusion: Overall, this study underscores the potential of solid dispersion formulations, particularly the 20:1 ratio of PEG 4000 to acyclovir, in enhancing the oral bioavailability of poorly water-soluble drugs, such as acyclovir, offering valuable insights for pharmaceutical formulations and drug delivery systems.
Dormir bien o dormir con apnea obstructiva del sueño
Authors: Martínez Luna Monserrat , Ángeles Castellanos Alberto Manuel
Published: September 2024

Los seres humanos realizamos gran cantidad de actividades, que hacen necesario tanto la ingesta de alimentos como el descansar, para poder recuperar la energía y estar listos para un nuevo día. La mejor forma de descansar es durmiendo. Estudios nos han permitido saber que el sueño es primordial para el buen funcionamiento del cuerpo y del cerebro, por lo cual es sumamente importante dormir, y no sólo dormir sino dormir bien. Un buen sueño se basa en el número de horas que dormimos y su calidad. Para lograrlo debemos tener buenos hábitos, que incluyen: un horario regular para dormir, evitar la ingesta de cafeína o alimentos pesados, realizar ejercicio, entre otros. Actualmente conocemos varios trastornos del sueño que obstaculizan un buen dormir, uno de los más prevalentes en la población mexicana es el síndrome de apnea obstructiva del sueño, en el que las vías respiratorias superiores se obstruyen mientras dormimos, produciendo una reducción o detención del flujo de aire. Si detectamos está enfermedad podemos tratarla y recuperar un buen sueño, para alcanzar una buena calidad de vida.
Sed de respuestas: explorando los misterios detrás de las sequías
Authors: Cosmes Martínez Cedrela , Ventura Houle René
Published: September 2024

Las sequías son fenómenos naturales que tienen consecuencias significativas para los seres humanos. Según un estudio de la Organización Mundial Meteorológica, las sequías han causado pérdidas globales superiores a los 250 mil millones de dólares y la muerte de 650,000 personas en un período de 50 años. Aunque en redes sociales y medios convencionales se encuentran diversos contenidos sobre experiencias personales, noticias y fotografías relacionadas con las sequías, hay una falta de difusión sobre los fenómenos meteorológicos que las originan. Entre estos fenómenos destacan “El Niño Oscilación del Sur” (enos), las células de circulación general atmosférica, las regiones monzónicas y las corrientes de chorro. Estos fenómenos, junto con la interacción con los océanos, que actúan como grandes fuentes de humedad, juegan un papel crucial en la formación de sequías. Además, las actividades humanas han amplificado el impacto de estos fenómenos naturales, impidiendo que el planeta desarrolle mecanismos naturales de adaptación a la velocidad necesaria. Comprender tanto los fenómenos meteorológicos que promueven las sequías como la influencia humana en acentuar sus efectos es fundamental para desarrollar planes efectivos de respuesta y mitigación a nivel local y global.
Fuzzy Analytic Hierarchy Process (FAHP) Based Performance Assessment of Textile Industry in Tirupur
Authors: R Brindha , S Devimani , v Subhashini , M Bharathi , Kavitha Dr. S. , Singh Charanjit , R Soniya , V Manopriya
Published: September 2024

Abstract: This study explores the use of Fuzzy Analytic Hierarchy Process (FAHP) to evaluate and prioritize criteria in supply chain management within the textile industry of Tirupur district. Utilizing a detailed questionnaire reviewed by experts with over 30 years of industry experience, the study conducted pairwise comparisons of key criteria: cost (C1), quality (C2), time delivery (C3), and management and organization (C4). By applying FAHP, which effectively handles uncertainties in decision-making, the study determines the relative importance of these criteria. The findings provide a structured method for improving decisionmaking in textile supply chain operations, integrating fuzzy logic with the traditional AHP framework to enhance the management and optimization of supply chain processes.
Hexagon Sustainability: Dekonstruksi Pentuple Bottom Line
Authors: Handayani Susi
Published: September 2024

Purpose: to explain how the concept of comprehensive sustainability is based on an Islamic perspective (Al Quran and Hadith).
Methodology/approach: This research is a study using the method of literature study on the topic of sustainability in an Islamic perspective. Data analysis in this study uses the concept of technology to deconstruct the Pentuple Bottom Line (PBL) concept. This research will present the hexagon bottom line concept, which is more complete than the PBL, QBL, and TBL concepts.
Findings: Sustainability consists of six elements: profit that profit or welfare in the economic aspect is important, but must be balanced with other P; planet means that maintaining the natural environment as a counterweight to the operational activities of an organization's contribution; people which means that a balance with the welfare of the community (internal and external to the organization) or the community is important to contribute to the corporation; prophet explains that mental and spiritual balance in the process of preserving the life of an organization; purpose that the real purpose and happiness of humans is to meet God, so humans must be able to maintain habluminallah well; phenotechnology explains that the phenomenon of information technology must be an important part of maintaining corporate survival.
Practical implications: The implementation of sustainability should be done comprehensively by taking into account the elements of profit, people, planet. Prophet, purpose, and phenotechnology.
Originality/value: This research adds technological elements to the PBL concept, thus deconstructing the PBL concept. The deconstruction in this research will be able to produce a new concept based on the Islamic perspective (Al Quran and Hadith).
Akuntabilitas Kinerja Instansi Pemerintah: Faktor-Faktor yang Memengaruhinya
Authors: Azmi Rosayda  , Icuk Rangga Bawono  , Oman Rusmana
Published: September 2024

Purpose : The research was conducted to examine whether there is an effect of performance-based budget variables, government internal control systems, compliance with laws and regulations, and human resource competencies on the performance accountability of public sector agencies in the Regional Work Unit in Pemalang Regency.
Methodology/approach: The use of a sample of 120 respondents spread across each Pemalang Regency using questioner. There are criteria needed in collecting research samples using purposive sampling method.
Findings: The results of research with SPSS version 25 provide conclusions performance-based budgeting affects the performance accountability of public sector agencies,  the government internal control system does not affect the performance accountability of public sector agencies, compliance with laws and regulations does not affect the performance accountability of public sector agencies, human resource competence affects the performance accountability of public sector agencies.
Practical implications: This research is expected to be a reference material for local government officials in making decisions regarding the performance accountability of government agencies.
Peran Mediasi Good University Governance Terhadap Kinerja Utama Perguruan Tinggi
Authors: Fitrah Akidah , Mustiningsih Mustiningsih , Karjo Etatok Rindang , Prastiawan Arif
Published: September 2024

Purpose: This research aims to empirically test the influence of performance-based budgeting and remuneration on the main performance of higher education institutions which is mediated by good university governance
Methodology/approach: This research is causal research with a quantitative approach using path analysis. The data used is primary data obtained from a sample of 42 people by distributing questionnaires using Google Form. Answer measurement uses a Likert scale.
Findings: Performance-based budgeting mediated by good university governance has a significant effect on the main performance of higher education institutions. Remuneration mediated by good university governance has a significant effect on the main performance of higher education. Performance-based budgeting has a significant effect on good university governance. Remuneration has a significant effect on good university governance. Performance-based budgeting cannot directly improve the main performance of higher education institutions because it does not have a significant effect. Direct remuneration cannot improve the main performance of higher education because it does not have a significant effect. Good university governance has a significant effect on the main performance of higher education.
Practical implications: Improving higher education performance can be done through the application of good university governance principles such as transparency, accountability, responsibility, independence and justice as well as the implementation of performance-based budgets and effective remuneration to realize the implementation of good university governance.
Originality/value: There are many research results on performance-based budgeting and remuneration on higher education performance with inconsistent results, so the research was conducted to fill the research gap in previous research by using good university governance as a mediating variable to improve higher education performance from the implementation of performance-based budgeting and remuneration.
Good Corporate Governance Dan Environmentalal, Social, Governance Disclosures Di Indonesia
Authors: Fujianti Lailah , Nelyumna Nelyumna , Azizah Widyaningsih , Astuti Sinta Budi , Hilmiyah Nurul , Qodriyah Anninsa Lailatul
Published: September 2024

Purpose: This research aims to confirm the roles of Good Corporate Governance (GCG) and Environmentalal, Social, Governance (ESG) Disclosures in Indonesia.
Methodology/approach: The research method employed is a quantitative approach using secondary data. The sample was selected using purposive sampling, resulting in 161 manufacturing companies listed on the Indonesia Stock Exchange in 2021. The research analysis technique utilizes multiple linear regression.
Findings:The research results reveal a significant positive role of the Board of Commissioners and Independent Board of Commissioners in ESG disclosure, whereas the Audit Committee does not play a significant role in ESG.
Practical implications: The number of members in the Board of Commissioners and Independent Board of Commissioners can stimulate an improvement in ESQ disclosure. However, the presence of the Audit Committee has not been able to demonstrate a role because Indonesian companies form an audit committee merely to comply with existing regulations.
Originality/value: The limited research examining Environmentalal, Social, Governance Disclosures in Indonesia has been identified. Previous research results indicate that the variable playing a significant role in promoting disclosure improvement is Good Corporate Governance (GCG). Therefore, this study further investigates the role of GCG in enhancing ESQ disclosures.
Does Social Management Process Matter?
Authors: Fitriya Elok , Tjahjadi Bambang
Published: September 2024

Purpose: The aim of this research is to find out whether social environment is a mediating variable in the influence of the main director's structure on management performance.
 Methodology/approach: The method used in this research is a qualitative research method sourced from secondary data collected by researchers through OSIRIS data from 709 companies whose shares are publicly traded on the Indonesia Stock Exchange.
Findings: The findings show that the influence of the composition of the board of directors on company performance varies greatly among social environments.
Practical Implications: This research adds to research references on the influence of governance on performance which is moderated by the company's social environment.
Originality/value: the novelty in this research is adding a new variable, namely the social environment as a mediating variable.
Environmental, Social, And Governance (ESG) Disclosure, Intellectual Capital And Firm Value: The Moderating Role Of Financial Performance
Authors: Pramesti Widya Cita , Sudarma Made , Ghofar Abdul
Published: September 2024

Purpose: This study aims to empirically examine the effect of Environmental, Social, and Governance (ESG) disclosure and intellectual capital on firm value moderated by financial performance.
Methodology/approach: This study uses a quantitative approach with a positivism paradigm. The sample in the study was 125 observations from 25 energy sector companies listed on the Indonesia Stock Exchange during the 2018-2022 period. The data analysis technique in this study uses Hierarchy Regression Analysis through the use of Multiple Regression Analysis and Moderated Regression Analysis (MRA).
Findings: The results showed that Environmental, Social, and Governance (ESG) disclosure has no effect on firm value, while intellectual capital has a positive effect on firm value. This study also shows that financial performance is able to moderate by strengthening the relationship between Environmental, Social, and Governance (ESG) disclosure and intellectual capital on firm value.
Practical implications: Companies should strengthen and pay more attention to Environmental, Social, and Governance (ESG) disclosure to fulfill the needs of interested parties. Investors should also consider more financial and non-financial information in assessing companies for decision making.
Originality/value: This study is a development of previous research that examines separately the effect of Environmental, Social, and Governance (ESG) disclosure and intellectual capital on firm value. This study also adds financial performance variables with Return on Assets measurement as a moderating variable.
Peran Moderasi Strategi Bisnis Di Antara Thin Capitalization Rule Dan Penghindaran Pajak
Authors: Hendrastuti Ranindya , Sukoharsono Eko Ganis , Iqbal Syaiful
Published: September 2024

Purpose: This  study  aims  to  analyze the  effect  of  thin capitalization rule  on  tax avoidance  moderated  by  business strategy.
Methodology/approach: The research method used is a quantitative approach with secondary data. Samples were taken  using  purposive  sampling and confirmatory factor analysis result ranking to  obtain  30  multinational companies   registered   on   the   IDX during  the  2014-2019  period excluded multinational companies which are not PMK-169 subject.  So, the total observations data is 180. The research analysis techniques using hierarchical regression analysis.
Findings: The results showed that business strategy can moderate between thin capitalization rule and tax avoidance. The defender business strategy weakens the negative influence of the Thin Capitalization Rule on tax avoidance, whereas the prospector business strategy strengthens the negative influence of the Thin Capitalization Rule on tax avoidance.
Practical implications: The government could consider easing the Thin Capitalization Rule for companies operating in business sectors dominated by prospectors and tightening the rules for companies operating in business sectors dominated by defenders.
Originality/value: There    are    still   no    research references    regarding    thin capitalization rule    on    tax avoidance   moderated   by   business strategy.   This research develops previous research by adding business strategy with confirmatory factor analysis in the moderation model.
Assessing Fraud Deterrence In Private Health Clinics: Policy Implications From West Java
Authors: Koerniawan Koenta Adji , Murti Galuh Tresna , Saraswati Rr Sri , Hilda Hilda
Published: September 2024

Purpose: Investigate whether the application of the Fraud Deterrence Propeller (FDP) protocol to assess the entity's maturity level in deterring fraud in privately owned health clinics can be applied, and investigate how the West Java provincial health service regulations relate to preventing fraud in health clinic providers.
Methodology/approach: Using a qualitative case study approach with post-positivism philosophy. In-depth interviews with 10 key informants, as well as field observations and literature reviews, were conducted. Data is processed with QDA Miner.
Findings: The FDP protocol can be applied to health clinics in Bandung to assess an entity's fraud deterrence maturity level. The dimensions of the FDP concept are used in fraud deterrence policies in the health environment of West Java Province, but are mandatory only in government-owned clinics, and do not apply to private clinics.
Practical implications: Private health clinic providers understand the urgency of implementing the FDP protocol to assess fraud prevention maturity. The West Java provincial health service is considering expanding fraud deterrence regulations for private health clinics, especially the implementation of an internal control system and Fraud Control Plan (FCP) and Whistle-Blowing System.
Originality/value: The novelty of this research is the use of the Fraud Deterrence Propeller (FDP) protocol in private health clinic providers.