bluuebunny/crossref_metadata_2025 huggingface dataset:
Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case report
Authors: Zhang Sijia , Chen Leichong , Zhu Kuikui , Meng Rui
Published: March 2023

In recent years, with the opening of the era of precision therapy, the treatment of patients with positive driver genes is a hot issue in global research. EGFR is the most common driver gene in NSCLC, with a positivity rate of 17%. Although targeted drugs for EGFR mutations can benefit this population with efficacy, target therapy resistance inevitably occurs. The presented case suggests that a patient with advanced lung adenocarcinoma with EGFR mutation who developed pathological-type conversion of small cell lung cancer complicated with the development of hypertropic pulmonary osteoarthropathy (HPOA) after 6 months of targeted therapy. This case demonstrates that early diagnosis of HPOA can predict the occurrence of target resistance and pathologic conversion in patients with positive driver genes, providing new clues for the clinical management of lung cancer.
Analysis of Varying Micrornas as a Novel Biomarker for Early Diagnosis of Preeclampsia: A Scoping Systematic Review of the Observational Study
Authors: Athif Zhafir Asyura Muhammad Mikail , Komariah Maria , Amirah Shakira , Faisal Emir G. , Maulana Sidik , Platini Hesti , Pahria Tuti
Published: March 2023

Background:

Preeclampsia (PE) is a pregnancy-related syndrome with moderate mortality. Early diagnosis of the condition remains difficult, with the current diagnostic modalities being ineffective. The varying microRNAs (miRNAs) as a novel biomarker pose an alternative solution with their potential to be reviewed.

Methods:

This study follows the Preferred Reporting Item for Systematic Review and Meta-Analysis Extended for Scoping Review (PRISMA-ScR). PubMed/MEDLINE, CENTRAL/Cochrane, ProQuest, Science Direct, and Wiley Online Library were used for this review. We only include observational studies. A critical appraisal was assessed in this study using QUADAS-2.

Results:

We retrieved 30 observational studies fulfilling the set criteria. Data extracted were synthesized qualitatively based on miRNAs that are more prominent and their area-under-the-curve (AUC) values. In total, 109 distinct dysregulated miRNAs were identified in comparison to healthy controls, with 10 of them (mir-518b, mirR-155, mirR-155-5p, miR-122-5p, miR-517-5p, miR-520a-5p, miR-525-5p, miR-320a, miR-210, and miR-210-3p) being identified in two or more studies. A brief look at the results shows that 49 miRNAs are downregulated and 74 miRNAs are upregulated, though the fold change of the dysregulation in all studies is not available due to some studies opting for a visual representation of the differences using whisker plots, bar charts, and heat map diagrams to visualize the difference from the reference control.

Conclusions:

This study has analyzed the potential of varying miRNAs as potential diagnostic biomarkers and how they might be used in the future. Despite this, potent miRNAs identified should be more emphasized in future research to determine their applicability and connection with the pathogenesis.
Prachchanna and Pratisarana in the management of Shitada
Authors: Chaudhary Shraddha , Vaghela D. B.
Published: March 2023

Shitada, one of Dantamoolagata roga (~gum disorders), can be correlated with gingivitis based on similar symptomatology. A 30-year-old male patient presented to the outpatient department of an Ayurveda hospital with the complaints of bleeding, inflamed, mild blackish discolored gums associated with halitosis for three years. The condition was managed by Raktamokshana by Prachchanna vidhi (~bloodletting by scarification or multiple incisions), Pratisarana (~rubbing of medicated paste over gums) with Priyangvadi churna mixed with Madhu (~honey), and Triphala churna orally with lukewarm water. The total treatment period was 30 days, and the patient was followed up for the next two months. Satisfactory improvement was noticed after the treatment.
Management of Urethral Stricture (Mutrapraseka sankocha) by Uttarabasti and oral medicines
Authors: Dwivedi Amarprakash P , Mohapatra Bibek Kumar , Pathrikar Anaya
Published: March 2023

Urethral stricture is a disease condition in which there is the narrowing of the lumen of the urethra. In established conventional medicine, the treatment includes urethral dilation, urethrotomy, and urethroplasty having varied prognoses. As per the Ayurvedic perspective, the condition can be correlated with Mutrapraseka sankocha (~urethral stricture). Uttarabasti (~intra urethral douche) is one of the effective procedures for urethral stricture. A single case study of 24-year-old male patient suffering from urethral stricture for four years has been illustrated here. The patient had complaints of straining during micturition, burning and dribbling micturition, and unsatisfactory urination along with the increased frequency of micturition. The patient has taken conventional treatment without significant improvement and approached for Ayurvedic treatment. After taking a detailed history and thorough examination, it was planned to administer Uttarabasti using the combination of Tila taila (10 ml), Saindhavadi taila (3 ml), Yavakshara taila (2 ml) for eight days along with Gokshuradi guggulu (500 mg) twice a day with lukewarm water, and Varunadi kwatha (30 ml) twice a day with an equal amount of water internally for 30 days. The patient showed remarkable improvement after the treatment. This therapeutic interventional case study revealed that Uttarabasti for eight sittings along with internal drugs provides significant relief in symptoms of urethral stricture.
Simulation-based Ultrasound Curriculum for Novice Clinicians to Assess Neonatal Endotracheal Tube Position
Authors: Huang Diana , Watkins Laura A. , Weinschreider James , Ghazi Ahmed , Wang Hongyue , Dadiz Rita
Published: March 2023

Background:

To evaluate the efficacy of a simulation-based mastery curriculum to train clinicians with limited-to-no sonography experience how to use ultrasound (US) to assess neonatal endotracheal tube (ETT) positioning.

Methods:

In a single-centered, prospective, educational study, 29 neonatology clinicians participated in a simulation-based mastery curriculum composed of a didactic lecture, followed by a one-on-one simulation session using a newly designed, three-dimensional (3D) printed US phantom model of the neonatal trachea and aorta. After mastery training, clinicians were evaluated with a performance checklist on their skills obtaining US images and assessing ETT positioning in the US phantom model. They also completed pre- and postcurriculum knowledge assessment tests and self-assessment surveys. The data were analyzed using Wilcoxon signed rank tests and repeated measures analysis of variance.

Results:

The mean checklist score improved significantly during three attempts (mean difference: 2.6552; 95% confidence interval [CI]: 2.2578–3.0525; P < 0.0001). The mean time to perform US decreased significantly from the first to third attempt (mean difference: −1.8276 min; 95% CI: −3.3391 to − 0.3161; P = 0.0196). In addition, there was a significant improvement in median knowledge assessment scores (50% vs. 80%; P < 0.0001) and survey ratings on knowledge and self-efficacy (P < 0.0001).

Conclusion:

Clinicians with limited-to-no sonography experience demonstrated improved knowledge and skill acquisition in using US to assess ETT positioning through simulation-based mastery training. The use of 3D modeling enhances simulation experiences and optimizes the quality of training during limited opportunities to achieve procedural competency in a controlled environment before further application into the clinical setting.
Subacromial Content to Subacromial Space Ratio in Neutral Position of the Arm as Diagnostic Criteria of Subacromial Impingement Syndrome
Authors: Bacha Raham , Gilani Syed Amir , Hanif Asif , Manzoor Iqra
Published: March 2023

Background:

Shoulder impingement syndrome is one of the main causes of shoulder disability of working-class individuals. Currently, dynamic sonography of the shoulder is the modality of choice for the evaluation of shoulder impingement syndrome. The ratio of subacromial contents (SAC) and subacromial space (SAS) in neutral arm position could be used as a diagnostic parameter for the subacromial impingement syndrome (SIS), especially in patients who have difficulties in the elevation of their shoulders due to pain. To use the SAC to SAS ratio as a sonographic criterion for the diagnosis of SIS.

Methods:

SAC and SAS of 772 shoulders were vertically measured in coronal view with linear transducer 7–14MHz of Toshiba Xario Prime ultrasound unit, while the patient arm was kept in the neutral position. The ratio of both the measurements was calculated, to be used as a diagnostic parameter of the SIS.

Results:

The mean SAS was 10.79 ± 1.94 mm and SAC was 7.65 ± 1.43 mm. SAC-to-SAS ratio for normal shoulders was a focused value with narrow standard deviation (0.66 ± 0.03). However, shoulder impingement is confirmed by any value falls out of the range of ratio for normal shoulders. Area under the curve at 95% confidence interval was 96%, while the sensitivity at 95% confidence interval was 99.25% (97.83%–99.85%), and specificity was 80.86% (76.48%–84.74%).

Conclusion:

SAC-to-SAS ratio in neutral arm position is a relatively more accurate sonographic technique for the diagnosis of SIS.
Point-of-care Ultrasound Diagnosis of Gastric Outlet Obstruction Syndrome
Authors: Gutiérrez-Rojas Ángela , Tung-Chen Yale , Hernández-Montero Esther , Eisenhofer Ane Andrés , Diego Itziar
Published: March 2023

Gastric Outlet Obstruction (GOO) is a clinical syndrome characterized by postprandial vomiting, epigastric pain, and abdominal distension due to mechanical or motility disorders. The suspicion will mainly rely on abdominal radiological imaging (computed tomography, barium studies) that might not be widely available or even be contraindicated. We report a 65-year-old male who developed progressive epigastralgia, anorexia, and vomiting. Physical examination revealed mild abdominal distension and epigastric tenderness on deep palpation. With the presumptive diagnosis of gastric outlet obstruction, an abdominal point-of-care ultrasound (POCUS) was performed and showed impaired gastric emptying and a “target sign.” A gastroscopic exploration confirmed inflammatory pyloric stenosis due to coexisting antral and duodenal ulcers. POCUS could play an essential role in the easy ultrasonographic diagnosis of gastroparesis, helping to differentiate from other causes of obstruction and even raise suspicion in the diagnosis of pyloric stenosis as a consequence of a GGO. POCUS may serve as a first-line imaging test that can raise suspicion of this difficult to diagnose and probably underreported disease.
Triple-negative Breast Cancer Arising in a Fibroadenoma in BRCA 1 Mutated Patient
Authors: Brunetti Nicole , Valente Irene , Pitto Francesca , Calabrese Massimo
Published: March 2023

We describe the case of a 35-year-old woman who comes to our institute with a palpable lump on her left breast. Clinically the mass was mobile, nontender and with no nipple discharge. Sonography revealed a circumscribed, oval-shaped, and hypoechoic mass, suggestive of a benign lesion. We performed an ultrasound-guided core needle biopsy that demonstrated multiple foci of high-grade (G3) ductal carcinoma in situ arising on fibroadenoma (FA). Subsequently, the patient had surgical excision of the mass with a final diagnosis of triple-negative breast cancer arising on FA. After diagnosis, the patient performs a genetic test that detects the BRCA 1 gene mutation. A review of the literature demonstrated only two cases of triple-negative breast cancer on FA. In this report, we describe another such case.
Role of Bronchoscopic Cytology in Diagnosis of Pulmonary Lesions
Authors: Kedige Anjali Rao , Dinesh Udipi Shastri
Published: March 2023

Objectives:

Respiratory cytology specimens such as bronchoalveolar lavage (BAL) and bronchial wash (BW) obtained using a fiberoptic bronchoscope are very useful in detecting or ruling out various inflammatory conditions, infections, and neoplastic lesions. A study was carried out to determine the usefulness of respiratory cytology in the diagnosis of pulmonary lesions and the limitations of cytology if any, and correlate the results of cytology with biopsies wherever possible.

Methods:

All bronchoscopic cytology and biopsy specimens received at the pathology laboratory of this tertiary care institute between June 2014 and May 2017 were analyzed. Cytology smears were stained with Leishman's stain, hematoxylin and eosin (H and E), Papanicolaou (PAP), and Ziehl–Neelsen (ZN) stain for all cases and special stains wherever needed. Slides prepared from biopsy specimens were stained with H and E. Immunohistochemistry was used for confirmation and further typing of malignant lesions and diagnosis rendered was compared with the corresponding cytology diagnosis.

Results:

A total of 120 specimens of BAL or BW cytology with or without biopsy were analyzed. Thirty-three were diagnosed as non-specific inflammatory lesions. The most common malignancy diagnosed by cytology was adenocarcinoma followed by squamous cell carcinoma. Correlating BAL with biopsy specimens, the sensitivity, specificity, and diagnostic accuracy of BAL were 100%, 88.8%, and 91.6%, respectively. Correlating BW with biopsy specimens, the sensitivity, specificity, and diagnostic accuracy of BW were 85.6%, 85.6%, and 85.6%, respectively.

Conclusions:

Accurate diagnosis can be made from the examination of bronchoscopic cytology specimens in pulmonary inflammation, tuberculosis, fungal infections, and malignancies. Combining respiratory cytology with biopsy and ancillary techniques can aid in better subtyping of neoplastic lesions.
Intrabiliary rupture of hepatic echinococcosis
Authors: Farooq Sardar Muhammad , Liu Wenya
Published: March 2023

Echinococcosis is a zoonotic parasitic disease caused by the larval stages of the Taeniid cestode species within the genus echinococcosis. The most commonly affected organ is the liver. Hepatic hydatid cysts have various complications, including superinfection and biliary, intrathoracic, and abdominal rupture. Intrabiliary rupture is the most common complication of hepatic hydatid cysts and is associated with high morbidity and mortality. Urgent imaging diagnosis and surgical management are required in these cases.
High-dose dual therapy versus bismuth-containing quadruple therapy for the treatment of helicobacter pylori infection: A meta-analysis of randomized controlled trials
Authors: Zhang Chong , Zhang Jun , Cheng Yu-Jie
Published: March 2023

Background:

Helicobacter pylori (H. pylori) infection is one of the most important public health issues, and bismuth-containing quadruple therapy (BQT) is the first-line therapeutic option. This study aimed to compare the efficacy and safety of high-dose dual therapy (HDDT) and BQT in eradicating H. pylori.

Methods:

Randomized controlled trials (RCTs) were retrieved from Pubmed, Embase, and Cochrane Library to evaluate the effects of HDDT and BQT on H. pylori infection from 2002 to August 31, 2022 (last 20 years). A meta-analysis was conducted using Review Manager 5.4 and dichotomous data were estimated by the risk ratio (RR) and the 100% confidence interval (CI). A heterogeneity test and publication bias adjustment were carried out using Stata 12.0.

Results:

5604 participants from 14 RCTs were included in this meta-analysis. The eradication rates of H. pylori in the HDDT group and the BQT group were 87.46% and 85.70%, respectively. There was a bordered significant difference (RR = 1.02, 95% CI: 1.00 ~ 1.04, P = 0.03) in the intention-to-treat (ITT) analysis. Inconsistently, in per-protocol (PP) analysis, HDDT showed similar efficacy to BQT (89.97% vs 89.82%, RR = 1.00, 95% CI: 0.99 ~ 1.02, P = 0.67). HDDT showed fewer frequent adverse events than BQT (13.00% vs 31.05%, RR = 0.41, 95% CI: 0.33 ~0.50, P < 0.00001). After adjusting for publication bias, the tendency did not change (RR = 0.49, 95% CI: 0.44 ~ 0.55, P < 0.00001). The compliance of the HDDT group has no significant difference compared with the BQT group (95.88% vs 93.84%, RR = 1.01, 95% CI: 1.00 ~ 1.03, P = 0.14).

Conclusion:

HDDT achieved a non-inferiority eradication rate, fewer side effects, and similar compliance compared with BQT.
Diversity characteristics of four‐element ring slot‐based MIMO antenna for sub‐6‐GHz applications
Authors: Kaushal Vipul , Birwal Amit , Patel Kamlesh
Published: March 2023

This paper proposes four‐ring slot resonator‐based MIMO antennas of 75 × 150 mm2 without and with CSRR structures in the sub‐6‐GHz range. These orthogonal‐fed antennas have shown diverse characteristics with dual polarization. L‐shaped parasitic structures have increased the isolation (i.e., >40 dB) in the single‐element antenna over the band of 3.4 GHz–3.8 GHz. A set of three CSRR structures in the MIMO antenna reduced the coupling between antenna ports placed in an inline arrangement and enhanced the isolation from 12 dB to 20 dB and the diversity characteristics. The S‐parameters of both MIMO antennas are measured and used to evaluate MIMO parameters like ECC, TARC, MEG, and channel capacity loss. The simulation results show the variations in the gain and directivity on exciting linear and dual polarizations. The diversity performance of the reported MIMO antennas is suitable for 5G applications.
Results of excavation at the Roman Period site in Podegrodzie, Nowy Sącz district
Authors: Madyda-Legutko Renata , Tunia Krzysztof
Published: March 2023

In the Late Roman and the Early Migration Periods, i.e. the 4th and the early 5th centuries AD, in the Polish Western Carpathians, especially in the Sącz Basin, the adjacent Sącz Beskid Mts and Wyspowy Beskid Mts as well as in the Krosno-Jasło Basin, a significant intensification of settlement is observed. The area has been investigated through archaeological surface surveys and excavations; in the Sącz region, five sites have been excavated with the results published to date. This text presents the results of test excavation at yet another site, Podegrodzie 7, Nowy Sącz district. In the feature investigated there a rare jug ornamented with glossed triangles, several storage vessels of the Krausengefäße type, as well as some organic remains were discovered. Palaeobotanical analysis has shown that common barley (Hordeum vulgare) was the predominant species cultivated by the inhabitants of this territory. The radiocarbon date obtained from a charcoal sample corresponds to the chronology of the site determined by the ceramics typology. The results of the excavation at Podegrodzie 7 site are complemented with a map presenting the location of settlement in that area in the Late Roman and the Early Migration Periods.
Wheel-made pottery of the Przeworsk culture in the light of digital radiography examinations. Preliminary study of vessels from the microregion to the east of the lower Raba River
Authors: Okońska-Bulas Magdalena , Mikołajska Anna
Published: March 2023

The article presents the results obtained by examining wheel-made pottery with the use of digital radiography. As exemplified by selected fragments, the possibilities offered by this method of studying the production techniques applied in Przeworsk culture ceramics are presented. Vessel sherds from the younger and late Roman period from workshops located in the microregion east of the lower Raba River (sites in Strzelce Małe and Bessów) were analysed. Analysis of X-radiography images offers some insight into the features of the primary forming techniques used and the structure of the clay fabric.
Settlement patterns of the Prehistoric and Early Historic communities in the Kańczuga Upland
Authors: Kolebuk Ewelina
Published: March 2023

The aim of this paper is to reconstruct settlement preferences and the dynamics of cultural changes that occurred in the sheet of Polish Archaeological Record (Archeologiczne Zdjęcie Polski = AZP) no. 105–80, located on the Kańczuga Upland. The materials for analysis were collected over several seasons of surface surveys in which 210 archaeological sites were identified. The obtained results show that this region was very attractive for both hunter-gatherers and settled communities.
Unravelling Narratives of Empire in No Man’s Sky
Authors: Clark Kate Euphemia
Published: March 2023

Many scholars have looked at how players engage with games of Empire in ways that both reproduce and subvert capitalist-colonial narratives of resource accumulation, war, and conquest. This article examines the 2016 release of No Man’s Sky, and how the colonial conquest and resource gathering that are central to the gameplay quickly unravelled as players spent time with the game. Firstly, this article will explore how the release of No Man’s Sky initially replicated the myth of terra nullius, as well as an understanding of the environment as resources-in-waiting. This is contrasted with the fact that No Man’s Sky did not replicate the traditional triple-A structure of action, which leads the player to a playthrough that focuses on ‘bearing witness’ to the environment, rather than harvesting its resources to strengthen the player-character and progress through the game. However, major updates to No Man’s Sky fundamentally changed the player’s relationship to the game-world, further obscuring many of the moments of speculation that the initial release provided. This analysis demonstrates how games of Empire can create affective experiences that can inadvertently challenge the very narratives that they are enmeshed in. These moments are fleeting but provide a valuable insight into the role that games play in the crises of the Anthropocene.
Recenzja książki Andrzeja Pitrusa, Przebłyski piękna. Spotkania z Jonasem Mekasem
Authors: Kita Barbara
Published: March 2023

Andrzej Pitrus, Przebłyski piękna. Spotkania z Jonasem Mekasem,
Wydawnictwo w Podwórku, Nowe Horyzonty, Warszawa–Gdańsk 2022, ss. 268.
“And Gabriel Kept on Writing” (Megilla 16a). Literary Features of Traditions Involving Supernatural Entities in the Babylonian Talmud according to the Elyonim veTachtonim Project
Authors: Kosior Wojciech
Published: March 2023

“And Gabriel Kept on Writing” (Megilla 16a). Literary Features of Traditions Involving Supernatural Entities in the Babylonian Talmud according to the Elyonim veTachtonim Project In this paper, I explain the theoretical and pragmatic aspects of the annotation system of the literary features used in the Talmudic database developed within the Elyonim veTachtonim project. In the first section, I recapitulate the theses concerning the production of the Babylonian Talmud and operationalise the formal indicators (i.e., language and attribution) of its specific layers. In the second section, I review the scholarship on the Talmudic genres and propose a categorisation that adheres to the cross-cultural framework of the Elyonim veTachtonim project. In the final section, I offer an illustration: a qualitative scrutiny of a fragment from Berakhot 62a and a quantitative-qualitative analysis of the data gathered from the Talmudic inventory.
Polski etap „Marszu Pokoju Hiroszima–Auschwitz” 1962‒1963. Buddyjsko-pacyfistyczne i polityczne konteksty byłych niemieckich nazistowskich obozów koncentracyjnych jako miejsc pamięci o Zagładzie i II wojnie światowej
Authors: Skrzyński Przemysław
Published: March 2023

The Polish stage of the “Hiroshima-Auschwitz Peace March” 1962‒1963. Buddhist-pacifist and political contexts of former German Nazi concentration camps as places of remembrance of the Holocaust and World War II As a result of the increased activity of organizations for former prisoners of the concentration and extermination camps, shortly after World War II, the memory of events at KL Auschwitz-Birkenau reached a global scale. In February 1962, an interreligious group of four young people, led by Satō Gyōtsu (1919‒2018) – a monk from a Buddhist order named Nipponzan-Myōhōji (Nichiren tradition) – undertook to march between Hiroshima and Oświęcim. Their purpose was to tell the truth about the crimes committed in both cities and spread the ideas of pacifism and disarmament. Within ten months, they visited 22 countries. The article primarily analyzes the Polish stage of the “Peace March,” based on an analysis of materials written by veterans and former prisoners of the camp in Auschwitz as well as texts published in the daily press. The second part of the article deals with the religious aspect of the “Peace March” in a broader context, discussing the complicity and collective responsibility of religious organizations, including Buddhist, for the drama of World War II. This “Peace March,” according to the author, was a form of confession of repentance and religious redress.
Rancang Bangun Aplikasi Pemesanan Tiket Bus Online (BeTik Bus) Berbasis Website
Authors: Aryo Prasojo Gregorius , Kontesta Rezza Pana
Published: March 2023

Bus merupakan transportasi yang masih menjadi pilihan utama masyarakat didaerah yang mudah untuk di jangkau. Dengan membeli tiket melalui agen bus, masyarakat bisa menikmati layanan bus. Namun dalam proses transaksinya masyarakat melakukan transaksinya secara manual, cara ini masih kurang efektif dan efisien. Melalui aplikasi BeTik Bus berbasis website ini dapat mempermudah dalam membeli tiket bus, masyarakat tidak perlu menghabiskan waktu dan tenaga untuk memesan tiket, karena melalui aplikasi BeTik Bus berbasis website ini user atau pengguna dapat membeli tiket lebih cepat dan lebih bebas. Aplikasi ini juga mempunyai fitur cetak tiket yang berguna mempermudah calon pembeli untuk mendapatkan bukti non fisik tiket yang sudah dipesan dan tervalidasi oleh admin, sehingga dengan adanya rancang bangun aplikasi BeTik Bus ini bertujuan untuk membantu masyarakat, khususnya masyarakat didaerah perbatasan. Aplikasi BeTik Bus menggunakan metode waterfall. Berdasarkan penelitian yang telah dilakukan rancang bangun aplikasi BeTik Bus dapat digunakan oleh masyarakat untuk kebutuhan pemesanan bus secara online dan aplikasi ini nantinya akan dikembangkan di kabupaten bengkayang karena strategis dekat dengan perbatasan Indonesia – Malaysia yang menjadi titik mobilitas masyarakat.
On $k$-ranks of topological spaces
Authors: Jin Mengjie , Li Qingguo
Published: March 2023

In this paper, the concepts of $K$-subset systems and $k$-well-filtered spaces are introduced, which provide another uniform approach to $d$-spaces, $s$-well-filtered spaces (i.e., $\mathcal{U}_{S}$-admissibility) and well-filtered spaces. We prove that the $k$-well-filtered reflection of any $T_{0}$ space exists. Meanwhile, we propose the definition of $k$-rank, which is an ordinal that measures how many steps from a $T_{0}$ space to a $k$-well-filtered space. Moreover, we derive that for any ordinal $\alpha$, there exists a $T_{0}$ space whose $k$-rank equals to $\alpha$. One immediate corollary is that for any ordinal $\alpha$, there exists a $T_{0}$ space whose $d$-rank (respectively, $wf$-rank) equals to $\alpha$.
Continuous R-valuations
Authors: Goubault-Larrecq Jean , Jia Xiaodong
Published: March 2023

We introduce continuous $R$-valuations on directed-complete posets (dcpos, for short), as a generalization of continuous valuations in domain theory, by extending values of continuous valuations from reals to so-called Abelian d-rags $R$. Like the valuation monad $\mathbf{V}$ introduced by Jones and Plotkin, we show that the construction of continuous $R$-valuations extends to a strong monad $\mathbf{V}^R$ on the category of dcpos and Scott-continuous maps. Additionally, and as in recent work by the two authors and C. Th\'eron, and by the second author, B. Lindenhovius, M. Mislove and V. Zamdzhiev, we show that we can extract a commutative monad $\mathbf{V}^R_m$ out of it, whose elements we call minimal $R$-valuations. We also show that continuous $R$-valuations have close connections to measures when $R$ is taken to be $\mathbf{I}\mathbb{R}^\star_+$, the interval domain of the extended nonnegative reals: (1) On every coherent topological space, every non-zero, bounded $\tau$-smooth measure $\mu$ (defined on the Borel $\sigma$-algebra), canonically determines a continuous $\mathbf{I}\mathbb{R}^\star_+$-valuation; and (2) such a continuous $\mathbf{I}\mathbb{R}^\star_+$-valuation is the most precise (in a certain sense) continuous $\mathbf{I}\mathbb{R}^\star_+$-valuation that approximates $\mu$, when the support of $\mu$ is a compact Hausdorff subspace of a second-countable stably compact topological space. This in particular applies to Lebesgue measure on the unit interval. As a result, the Lebesgue measure can be identified as a continuous $\mathbf{I}\mathbb{R}^\star_+$-valuation. Additionally, we show that the latter is minimal.
ESTUDO SOBRE GÊNERO E DIVERSIDADE SEXUAL: A CRUZADA IDEOLÓGICA
Authors: Beatriz Erivelton de Paula Moura , Almeida Wellingson Cavalcanti de , Verbicaro Soares Douglas
Published: March 2023

O presente artigo tem como objetivo fim a inserção da ideia de “ideologia de gênero” numa perspectiva constitucional, visando demonstrar que o Brasil segue, nesse momento, na contramão no que se refere à garantia de Direitos Humanos. O objetivo proposto, torna- se necessário no atual contexto de difusão das polêmicas sobre a questão de gênero na educação, aguçada a partir de um estudo de casos que o Plenário do Supremo Tribunal Federal (STF)  julgou inconstitucionais, especificamente a Arguições de Descumprimento de Preceito Fundamental (ADPF 461) proposta pela Procurador Geral da Republica - PGR,  em face do artigo 3°, X, parte final, da Lei 3.468, de 23 de junho de 2015, do Município de Paranaguá, Estado do Paraná, que dispõe sobre a aprovação do Plano Municipal de Educação de Paranaguá, vedando, no dispositivo atacado, política de ensino com informações sobre gênero ou orientação sexual. Utilizou-se o método dedutivo, com o auxílio das técnicas da pesquisa documental-legal, assim como doutrinas e jurisprudências sobre o tema.
IDENTITY RECOGNITION OPTIMIZATION BASED ON LBP FEATURE EXTRACTION
Authors: Fajri T Irfan , Rahmi Zulaida
Published: March 2023

ABSTRACT Unimodal systems have limited information that can be used for identity recognition systems. The multimodal system was created to improve the unimodal system. The multimodal system used in this study is the combination of the face and palms at the matching score level. Matching scores is done using the Weighted Sum Rule method. Extract features from each sample using the Local Binary Pattern (LBP) method. Meanwhile, large data dimensions are reduced by using the Principal Component Analysis (PCA) method. The distance between face and palm data is measured using the closest distance, namely the Euclidean Distance method. Benchmark dataset using ORL, FERET and PolyU. Based on testing on each database, an accuracy rate of 98% (ORL and PolyU) and 95% (FERET and PolyU) is obtained. The test results show that the multimodal system using the Hybrid method (PCA and LBP) biometric system runs well and optimally. Keywords: Artificial intelegency, recognition, LBP, multimodal
TABLE OF CONTENTS
Authors: Contents Table Of
Published: March 2023

TABLE OF CONTENTS
Molecular and morphological markers of neuronal death in acute cerebrovascular accidents
Authors: Kudryavtseva V. A. , Kuzmin E. A. , Moiseeva A. V. , Obelchakova M. S. , Sinitsina P. A. , Filistovich T. I. , Kartashkina N. L. , Piavchenko G. A. , Golubev A. M. , Kuznetsov S. L.
Published: March 2023

Acute cerebral circulation disorder is one of the most discussed issues in modern intensive care and neurology, as it is a severe condition, leading to disability or death of the patient, in the absence of immediate medical care. This review discusses general and specific biological markers of stroke, genetic markers of stroke, and current data on their diagnostic significance. The main mechanisms of brain tissue cell death in stroke, such as apoptosis, necrosis, ferroptosis, parthanatosis, sarmoptosis, autolysis, autophagy, oncosis, excitotoxic death are analyzed; the morphological features of the observed processes and their structural manifestations are reviewed. For each type of cell death in nervous tissue, the most frequently detected molecular markers are discussed: specific kinases, Toll-like receptors in the case of apoptosis; serine-threonine protein kinases, components of the polyubiquitin system detected in necrosis; transferrin 1 receptors, typical for ferroptosis; poly(ADP-ribose)-polymerase, whose activity increases in parthanatosis; slow Wallerian degeneration protein that accumulates during sarmoptosis; and other biomarkers characteristic of both individual types of nerve cell death and general pathological processes affecting the brain.
Angiopoietin-1 as a marker of endothelial dysfunction and a risk factor for acute kidney injury in patients with COVID-19: retrospective cohort study
Authors: Schepalina A. A. , Chebotareva N. V. , Akulkina L. A. , Brovko M. Yu. , Sholomova V. I. , Potapov P. P. , Valiulina D. S. , Moiseev S. V.
Published: March 2023

Recently, data have been published on the leading role of endothelial dysfunction in the development of severe COVID-19, including acute renal failure (AKI) and poor prognosis in this group of patients.

Aim. To define the role of angiopoetin-1(Ang-1) as a marker of endothelial dysfunction in development of AKI in patients, hospitalized with COVID-19.

Materials and methods. 76 patients with confirmed coronavirus infection were included in the study. AKI was diagnosed according to KDIGO 2012 criteria in 44 patients (group 1), 32 patients without sings of kidney disfunction were in group 2. Beside standard clinical and laboratory markers on admission we evaluated serum Ang-1 level with ELISA. We used regression analysis for AKI risk factors evaluation, we calculated odds ratio (OR) and 95% confidence intervals (CI). We used Cox regression for evaluation of risk of death.

Results. The serum level of angiopoietin-1 was significantly higher in patients with COVID-19 with AKI: 1.8 (1.5; 2.1) ng/ml vs 1.58 (1.29; 1.7) ng/ml in group 2, р < 0.01. In deceased patients, the level of Ang-1 at admission was significantly higher than in patients who was discharged: 1.91 (1.71; 2.32) ng/ml vs 1.58 (1.34; 1.67) ng/ml, respectively, p = 0.0001. In unifactorial regression analysis we confirmed, that increase of serum Ang-1 level >1.66 ng/ml on admission is the risk factor for AKI development in patients with COVID-19 (OR 5.7, 95% CI 1.7–19.1, р < 0.01). In Cox regression development of AKI increased the absolute risk of death: Hazard ratio = 5.159 (95% CI 1.839–14.469), p = 0.002.

Conclusion. The high serum level of Ang-1 in patients with COVID-19 at hospital admission is the marker of systemic endothelial dysfunction and the risk factor for AKI and poor prognosis.
Motor skills, concentration, and cardiorespiratory capacity in school athletes and non-athletes
Authors: Valencia Sánchez Wilder Geovanny , Arias Elkin Alberto , Marín Hernan , Cardona Danny , Pulido Sandra
Published: March 2023

Physical activity and sport are associated with significant benefits when practiced regularly, starting at school age. In Colombia, physical education classes are not taught to children in primary school. The Institute for Sport and Recreation (Instituto de Deportes y Recreación, INDER) enables access to systematic sport practice, guided by a professional, for children of public schools in Medellin, Colombia. Purpose: To identify differences in anthropometric variables, concentration, motor skills, and cardiorespiratory capacity between school-aged children who participate in a sport program and those who do not participate. Methods: The research design is cross-sectional. 290 schoolchildren of both sexes were evaluated with the GRAMI-2 test to verify motor skills, the test of Toulouse-Piéron to verify their ability to concentrate, and the Course-Navette test to verify their cardiorespiratory capacity. There are 141 evaluated students who belong to the Inderescolares program (10.1 ± 1.9 years, mean ± SD) and 107 that do not belong to the program (9.5 ± 2.5 years, mean ± SD). With this sample, a statistical power of 79% is achieved, and inferences can be made with a confidence level of 95%. Results: The results indicate no differences in anthropometric variables between children who participate in the sport program and those not participating. There were significant differences in three tasks and proportional differences in all six tasks of the GRAMI-2 test in favor of those children who participated. Cardiorespiratory capacity is also better in children who participate in the program, INDER Medellin. This pattern of improved performance in the participating children occurs in both boys and girls. Socioeconomic status could affect the performance of some tests that require a greater expenditure of energy. Conclusion: Schoolchildren between eight and 11 years of age who are not taught physical education classes at school but participate in a sport program obtain better performance in the tests to assess motor skills, concentration, and cardiorespiratory capacity than those who are also not taught physical education classes at school nor participate in a sport program.
Keywords: Physical Activity, Motor Skills, Concentration, Cardiorespiratory Capacity, Schoolchildren
Validação de conteúdo do instrumento “Plano de Ensino Individualizado aplicado à Educação Física” - Uma Proposta de Intervenção em Portugal
Authors: Lourenço Carla
Published: March 2023

A inclusão dos alunos na aula de Educação Física ainda enfrenta alguns problemas e muitos dos professores de Educação Física consideram que não se sentem preparados para o ensino inclusivo. O Plano de Ensino Individualizado aplicado à Educação Física é um documento que permite obter um plano de trabalho para que os professores possam trabalhar de modo mais eficaz, com os seus alunos com deficiência. O objetivo deste estudo foi relatar o processo de validação de conteúdo do instrumento “Plano de Ensino Individualizado aplicado à Educação Física” na população portuguesa. A amostra foi constituída por 12 juízes todos com formação superior em Educação Física e formação e/ou experiência em educação especial, a lecionar nos ensinos básico e secundário (n=6) e no ensino superior (n=6). Os participantes apresentavam idades compreendidas entre os 29 e 61 anos e 2 e 35 anos de serviço docente. O documento está estruturado em três partes: I. Informações sobre o estudante; II. Nível de desempenho do estudante e III. Programa de Educação Física. Em cada uma das partes os Juizes/juízes analisavam a clareza da linguagem, a pertinência teórica e viabilidade da aplicação. Manifestaram, ainda, a sua opinião acerca da proposta, podendo ou não, esta, ser mantida. Concluímos que, no geral, os juízes constataram que a informação era adequada e que deveria ser mantida. Foram, ainda, consideradas algumas sugestões apresentadas pelos juízes que participaram no estudo.
Palavras-chave: Inclusão; Educação Física; Plano de Ensino Individualizado; Portugal.
Rol del autoconcepto físico, motivación de logro y actitudes hacia la Educación Física en función del sexo (Role of physical self-concept, achievement motivation and attitudes towards Physical Education according to the sex)
Authors: Poblete-Valderrama Felipe , Vera Sagredo Angelica , Urrutia Medina Juan
Published: March 2023

Esta investigación entrega los resultados de un conjunto de variables de tipo socioemocionales respecto a la estima global de los estudiantes de educación secundaria en la clase de Educación Física (N=279). En el estudio se analizó el autoconcepto físico, la motivación de logro y la actitud hacia la Educación Física, tanto a nivel general como en sus diferencias por sexo. Con la finalidad de cuantificar el efecto de la incorporación de las distintas variables se realizaron análisis comparativos y modelos de regresión múltiple, mediante el método de pasos sucesivos o step wise. Los resultados muestran que existen diferencias estadísticamente significativas en el sexo femenino en dimensiones como ansiedad o agobio ante el fracaso y la dificultad percibida hacia la Educación Física. En cambio, los hombres se destacan en dimensiones relacionadas con el estado físico global, estima global, compromiso con el aprendizaje y preferencia por la Educación Física. Del mismo modo, los resultados generales del modelo permiten inferir que el 67,3% de la varianza de la estima global puede ser explicada por las variables incorporadas en el modelo, destacándose el impacto positivo de la apariencia, competencia percibida, compromiso hacia el aprendizaje, fuerza y el rol negativo de la ansiedad o agobio ante el fracaso.
Palabras clave: Autoconcepto; motivación; actitud del estudiante; educación secundaria; Educación Física
Abstract. This research provides the results of a set of socio-emotional variables regarding the global esteem of secondary school students in Physical Education class (N=279). The study analyzed physical self-concept, achievement motivation and attitude towards Physical Education, both at a general level and in its differences by sex. In order to quantify the effect of the incorporation of the different variables, comparative analyzes and multiple regression models were carried out, using the method of successive steps or step wise. The results show that there are statistically significant differences in the female sex in dimensions such as anxiety or overwhelm in the face of failure and the perceived difficulty towards Physical Education. On the other hand, men stand out in dimensions related to global physical condition, global esteem, commitment to learning and preference for Physical Education. In the same way, the general results of the model allow us to infer that 67.3% of the variance of Global Esteem can be explained by the variables incorporated in the model, highlighting the positive impact of appearance, perceived competence, commitment to learning, strength and the negative role of anxiety or overwhelm in the face of failure.
Keywords: Selfconcept; motivation; student attitude; secondary education; Physical education
Physical activity according to gender in Brazilian Physical Education textbooks
Authors: Moya-Mata Irene , Stieg Ronildo , Loro Alexandre , Junio Marques Soares Denilson , Dos Santos Wagner
Published: March 2023

One of the purposes of Physical Education is promoting physical activity through equal opportunities for boys and girls, accepting diversity. Aware of the power of the image for the reproduction of gender stereotypes, this research aimed to analyse its existence in Brazilian textbooks. The study was empirical, descriptive and comparative among analysed books that used content analysis and inferential statistics. The sample comprised 1327 images. These images concerned 10 Physical Education textbooks published by four Brazilian publishers who edited them as teacher’s guides for primary education between 2017 and 2018. A content analysis was carried out through the adaptation of the SAIMEF tool. The classification and categorization of the images were performed by five expert judges, using, as a criterion, the coefficient of agreement between them. The results indicated greater importance of images linked to the male gender, with a predominance of sports and fights as main activities, while the female gender is characterized by individual practices, such as gymnastics. The study concluded that Physical Education guides in Brazil convey a sports educational model, which can influence the choice of body practices and consolidate students’ imagination based on hegemonic standards present in society. Therefore, teachers need to make a critical analysis of these images to avoid promoting this hegemonic male sports model among primary and secondary school students in their physical education classes.
Keywords: textbook; gender, physical education, content analyses, Brazil.
Inteligencia emocional, resiliencia y satisfacción vital en el arbitraje deportivo (Emotional intelligence, resilience, and life satisfaction in sport refereeing)
Authors: Merino-Prados Helena , Molero David , Gavín-Chocano Óscar
Published: March 2023

La inteligencia emocional, la resiliencia y la satisfacción vital del colectivo arbitral de fútbol y futbol sala andaluz son constructos fundamentales para tomar decisiones durante un encuentro deportivo, por ello, esta investigación analizada la existencia de diferencias significativas en función de las variables sociodemográficas consideradas. La muestra estaba compuesta por 96 mujeres y hombres pertenecientes al comité de arbitral de la Real Federación Española de Fútbol (fútbol y fútbol sala). Los instrumentos utilizados fueron la Escala de Inteligencia Emocional de Wong Law (WLEIS-S), Escala de Resiliencia (RS-14) y Satisfaction with Life Scale (SWLS). Hemos encontrado correlaciones significativas entre todas las dimensiones de los instrumentos empleados. También se han encontrado diferencias significativas en función del género en algunas dimensiones de la inteligencia emocional y en satisfacción vital; y en algunas dimensiones de la inteligencia emocional en función de la especialidad arbitral. Entre las conclusiones destacamos la necesidad de formar al colectivo en inteligencia emocional, en especial en regulación emocional, para mejorar en el desarrollo de sus funciones.
Palabras clave: árbitro, deportes de equipo, inteligencia emocional, resiliencia, satisfacción vital.
Abstract. Emotional intelligence, resilience, and life satisfaction of Andalusian football and futsal referees are fundamental constructs to decision-making during a sporting event. Therefore, this research analyzed the existence of significant differences based on the sociodemographic variables considered. The sample consisted of 96 women and men belonging to the refereeing committee of the Royal Spanish Football Federation (football and futsal). The instruments used were the Wong Law Emotional Intelligence Scale (WLEIS-S), the Resilience Scale (RS-14), and the Satisfaction Life Scale (SWLS). We found significant correlations between all the dimensions of the instruments used. Furthermore, significant differences were also found according to gender in some dimensions of emotional intelligence and life satisfaction; and in some dimensions of emotional intelligence about refereeing discipline. Among the conclusions, it should be highlighted the need to train the collective in emotional intelligence, especially in emotional regulation, to improve the development of their functions.
Key words: emotional intelligence, life satisfaction, referee, resilience, team sports.