bluuebunny/crossref_metadata_2025 huggingface dataset:
Job crafting as dynamic displays of gender identities and meanings in male‐dominated occupations
Authors: Yu Ai , Jyawali Harishchandra
Published: December 2020

In this article, we explore how women craft their jobs in male‐dominated occupations in ways that respond to the job demands relating to contradictory gender expectations. With material from 21 interviews with female chefs working in professional kitchens, we show, through the lens of constructing gender identities and meanings at the gender‐body nexus, that three job crafting practices—negotiating physical competence, reframing creativity, and managing men co‐workers reactions—are invented as creative responses to gender‐related job demands. The findings contribute to the job crafting literature by showing that women's job crafting in male‐dominated occupations is less about increasing or decreasing certain types of job demands, but more about enacting “dynamic displays”—material, discursive, and fluid—of their gender identities and meanings as situated responses to a given job demand being made. Our research indicates the importance of understanding the conditions under which job crafting is mostly likely to generate positive, negative, or mixed experiences over time.
Utilization of absolute monocyte counts to predict cardiovascular events in people living with HIV
Authors: Bogorodskaya M , Lyass A , Mahoney TF , Borowsky LH , Sen P , Swirski FK , Srinivasa S , Longenecker CT , Massaro JM , D’Agostino RB , Triant VA
Published: December 2020

Objectives

Cardiovascular risk is increased in people living with HIV (PLWH). In HIV‐uninfected populations, total absolute monocyte count (AMC) has been shown to be predictive of future cardiovascular events (CVEs). We sought to determine whether AMC predicts CVEs in PLWH independent of established and HIV‐related cardiovascular risk factors.

Methods

We identified all PLWH within the Partners HIV Cohort without factors that could confound the monocyte count. CVE was defined as fatal or non‐fatal acute myocardial infarction or ischaemic stroke. Baseline‐measured AMC was defined as the average of all outpatient AMC counts a year before and after the baseline date. Multivariable Cox proportional hazards models were used to assess the association of baseline AMC with CVEs.

Results

Our cohort consisted of 1980 patients, with median follow‐up of 10.9 years and 182 CVEs. Mean (± SD) age was 41.9 ± 9.3 years; 73.0% were male. Mean CD4 count was 506.3 ± 307.1 cells/µL, 48% had HIV viral load (VL) < 400 copies/mL, and 87% were on antiretroviral therapy. Mean AMC was 0.38 × 103 ± 0.13 cells/µL. In multivariable modelling adjusted for traditional CV risk factors, CD4 cell count, and HIV VL, AMC quartile 2 (Q2) (HR = 1.01, P = 0.98), Q3 (HR = 1.07, P = 0.76), and Q4 (HR = 0.97, P = 0.89) were not significantly predictive of CVE compared with Q1.

Discussion

Baseline AMC was not associated with long‐term CVEs in PLWH. AMC obtained in routine clinical encounters does not appear to enhance CV risk stratification in PLWH.
Geochemistry, geochronology, and zircon Hf isotopes of Late Jurassic–Early Cretaceous granitoids in the Xing'an Massif, NE China: Implication for the Late Mesozoic tectonic evolution and crustal growth
Authors: Li Hai‐Na , Han Jun , Said Nuru , Yin Zhi‐Gang
Published: December 2020

This paper presents new zircon U–Pb geochronological, Hf isotopic and whole‐rock geochemical data for the granitic plutons in the Xing'an Massif, Northeast China, to constrain the Late Mesozoic tectonic evolution of the Mongol‐Okhotsk Ocean and the Paleo‐Pacific Ocean. The zircon U–Pb ages indicate that the granitoids emplaced during the Late Jurassic–Early Cretaceous. The granodiorites show an adakitic affinity with high Sr/Y ratios and low Yb (< 1.30 μg/g) contents. The monzogranites exhibit high SiO2, low MgO contents, enrichment in LILEs (Rb, K, and Th), and depletion in HSFEs (Ta, Nb, Zr, P, and Ti). Petrological and geochemical features of these monzogranites suggest that they are highly fractionated I‐type granitoids. In addition, the zircon εHf(t) values and two‐stage model ages (TDM2) are in the range of +2.6 to +8.1 and 669–1011 Ma, respectively, indicating that primary magma was generated by partial melting of juvenile lower‐crustal materials, and there was a significant crustal growth in the Phanerozoic in the Northeast China. Combined with the coeval granitoids widely exposed in the Xing'an Massif, we conclude that the Late Jurassic magma in Northeast China was generated in an extensional setting related to the closure of the Mongol‐Okhotsk Ocean, but the Early Cretaceous magma was related to the subduction of the Paleo‐Pacific Plate.
Apalutamide for metastatic, castration‐sensitive prostate cancer in the Japanese population: A subgroup analysis of the randomized, double‐blind, placebo‐controlled phase 3 TITAN study
Authors: Uemura Hirotsugu , Arai Gaku , Uemura Hiroji , Suzuki Hiroyoshi , Iijima Kazuyoshi , Nishimura Kazuo , Fujii Koji , Hatayama Tomoyoshi , Aoyama Junya , Deprince Kris , Lopez‐Gitlitz Angela , McCarthy Sharon , Larsen Julie S , Li Jinhui , Chi Kim N
Published: December 2020

Objective

To evaluate the efficacy and safety of apalutamide + androgen deprivation therapy versus androgen deprivation therapy alone in Japanese patients with metastatic castration‐sensitive prostate cancer from the phase 3, randomized, global TITAN study.

Methods

Men with metastatic castration‐sensitive prostate cancer randomly (1:1) received 240 mg apalutamide + androgen deprivation therapy or matching placebo + androgen deprivation therapy. The primary efficacy endpoints were radiographic progression‐free survival and overall survival. Secondary efficacy endpoints were time to cytotoxic chemotherapy, pain progression, chronic opioid use, and skeletal‐related events. Safety was also assessed.

Results

Of the 1052 patients included in the TITAN study, 51 (4.85%) were Japanese (apalutamide group, n = 28; placebo group, n = 23). In all, 81.8% of patients in the apalutamide and 71.8% in the placebo group did not experience radiographic progression or death, and the hazard ratio for radiographic progression‐free survival favored treatment with apalutamide (hazard ratio 0.712, 95% confidence interval 0.205–2.466; P = 0.59). At 24 months, 85.7% of patients in the apalutamide group and 81.5% in the placebo group were alive, and the hazard ratio for overall survival favored apalutamide (hazard ratio 0.840, 95% confidence interval 0.210–3.361; P = 0.805). In the interim analysis, the median radiographic progression‐free survival and overall survival were not reached in the apalutamide group and time to cytotoxic chemotherapy was delayed following apalutamide treatment. The safety profile of apalutamide in the Japanese subpopulation was comparable with that of the global population, except for skin rash.

Conclusions

The results of the present analyses suggest that apalutamide + androgen deprivation therapy in Japanese patients had favorable efficacy compared with androgen deprivation therapy alone, and these findings are comparable to those in the overall population. Apalutamide + androgen deprivation therapy can be considered as one of the therapeutic options for a broad spectrum of metastatic castration‐sensitive prostate cancer regardless of prior treatment and disease extent in Japanese patients.
Biogeographic mechanisms involved in the colonization of Madagascar by African vertebrates: Rifting, rafting and runways
Authors: Masters Judith C. , Génin Fabien , Zhang Yurui , Pellen Romain , Huck Thierry , Mazza Paul P. A. , Rabineau Marina , Doucouré Moctar , Aslanian Daniel
Published: December 2020

Aim

For 80 years, popular opinion has held that most of Madagascar's terrestrial vertebrates arrived from Africa by transoceanic dispersal (i.e. rafting or swimming). We reviewed this proposition, focussing on three ad hoc hypotheses proposed to render this unlikely scenario more feasible: (a) Could hibernation have helped mammals to reach Madagascar? (b) Could the aquatic abilities of hippopotamuses have enabled them to swim the Mozambique Channel? (c) How valid is the Ali‐Huber model predicting that eastward Palaeogene surface currents allowed rafts to reach Madagascar in 3–4 weeks? Finally, we explored the alternative hypothesis of geodispersal via short‐lived land bridges between Africa and Madagascar.

Location

East Africa, Madagascar, Mozambique Channel.

Taxa

Fish, amphibians, reptiles, birds, mammals.

Methods

We established colonization timeframes using molecular divergence dates estimated for Malagasy vertebrate lineages. We reviewed the likelihood of the “torpid waif” and “swimming hippopotamus” hypotheses, and re‐investigated Ali and Huber's model of Eocene jet‐like currents by tracking particle trajectories in currents simulated using the Institut Pierre‐Simon Laplace Earth System Model. Finally, we summarized recent geological findings from the Mozambique Channel, and used them to compile palaeosedimentological maps using PLACA4D.

Results

Madagascar's vertebrate fauna has complex origins. Hibernation is probably an adaptation to Madagascar's hypervariable climate, rather than a facilitator of mammal dispersal. Hippopotamus physiology precludes the ability to cross an oceanic channel deeper than 4 m and hundreds of km wide. The Ali‐Huber model of Palaeogene currents considerably underestimated the time required to cross the Mozambique Channel under simulated palaeogeographic conditions. New geological data indicate the existence of three short‐lived land bridges between Africa and Madagascar at 66–60 Ma, 36–30 Ma and 12–05 Ma.

Main conclusion

The three Cenozoic land bridges afford a more grounded hypothesis for the dispersal of Madagascar's extant biota than transoceanic rafting or swimming, although vicariance, island hopping and limited rafting also played a role.
Epigenetic changes caused by diabetes and their potential role in the development of periodontitis
Authors: Li Yanfen , Du Zhibin , Xie Xiaoting , Zhang Yangheng , Liu Huifen , Zhou Ziqian , Zhao Jing , Lee Ryan SB , Xiao Yin , Ivanoviski Saso , Yan Fuhua
Published: December 2020

Aims/Introduction

Periodontal disease, a chronic inflammation induced by bacteria, is closely linked with diabetes mellitus. Many complications associated with diabetes are related to epigenetic changes. However, the exact epigenetic changes whereby diabetes affects periodontal disease remain largely unknown. Thus, we sought to investigate the role of diabetes‐dependent epigenetic changes of gingival tissue in the susceptibility to periodontal disease.

Materials and Methods

We studied the effect of streptozotocin‐induced diabetes in minipigs on gingival morphological and epigenetic tissue changes. Accordingly, we randomly divided six minipigs into two groups: streptozotocin‐induced diabetes group, n = 3; and non‐diabetes healthy control group, n = 3. After 85 days, all animals were killed, and gingival tissue was collected for histology, deoxyribonucleic acid methylation analysis and immunohistochemistry.

Results

A diabetes mellitus model was successfully created, as evidenced by significantly increased blood glucose levels, reduction of pancreatic insulin‐producing β‐cells and histopathological changes in the kidneys. The gingival tissues in the diabetes group presented acanthosis of both gingival squamous epithelium and sulcular/junctional epithelium, and a significant reduction in the number and length of rete pegs. Deoxyribonucleic acid methylation analysis showed a total of 1,163 affected genes, of which 599 and 564 were significantly hypermethylated and hypomethylated, respectively. Immunohistochemistry staining showed that the hypomethylated genes – tumor necrosis factor‐α and interleukin‐6 – were positively expressed under the junctional epithelium area in the diabetes group.

Conclusions

Diabetes mellitus induces morphological and epigenetic changes in periodontal tissue, which might contribute to the increased susceptibility of periodontal diseases in patients with diabetes.
Breeding behaviour predicts patterns of natural hybridization in North American minnows (Cyprinidae)
Authors: Corush Joel B. , Fitzpatrick Benjamin M. , Wolfe Elizabeth L. , Keck Benjamin P.
Published: December 2020

Premating barriers such as variation in reproductive behaviour can evolve quickly, but because gametic and postzygotic incompatibilities often evolve more slowly, circumstances that bring gametes into contact can breach the boundaries of premating isolation. In aquatic environments, the gametes of organisms with external fertilization are released into a constantly moving environment and may come into contact with heterospecific gametes. In fishes, nest association (spawning in another species’ nest) is a behaviour that brings gametes from different species into close spatiotemporal proximity. These interactions might increase chances of hybridization, especially when multiple species associate with a single nest builder. This study addresses these interactions in the largest clade of North American freshwater fishes, the minnows (Cyprinidae). We compiled a list of over 17,000 hybrid specimens in conjunction with species distribution data, breeding behaviours, and an inferred phylogeny to test if breeding behaviour, in addition to evolutionary history, is an important predictor of hybridization. We find that breeding behaviour is a significant predictor of hybridization, even when phylogenetic relatedness and divergence time are accounted for. Specifically, nest associates are more likely to hybridize with other nest associates whereas non‐nesting species had relatively low rates of hybridization.
Increasing changes in visceral adiposity is associated with higher risk for colorectal adenoma: Multilevel analysis in a prospective cohort
Authors: Moon Jung Min , Im Jong Pil , Kim Donghee , Han Yoo Min , Soh Hosim , Song Ji Hyun , Yang Sun Young , Kim Young Sun , Yim Jeong Yoon , Lim Seon Hee , Kim Joo Sung
Published: December 2020

Background and Aim

While many studies demonstrated an association between visceral adiposity and colorectal adenoma (CRA), the effect of longitudinal changes in body fat composition on CRA is unclear. We investigated the longitudinal association between changes in visceral adiposity and CRA occurrence.

Methods

Between 2006 and 2018, 732 (62.8%) of the 1165 subjects in a prospective cohort voluntarily underwent follow‐up abdominal fat computed tomography and colonoscopy. We defined incident and recurrent CRA as adenoma detected at follow‐up colonoscopy from negative and positive adenoma at baseline colonoscopy, respectively. Multilevel survival analysis examined the longitudinal association between changes in visceral fat and CRA.

Results

During a median follow‐up of 7.4 years, 400 (54.6%) subjects developed CRA. In multivariable analysis, increasing changes in visceral adipose tissue (VAT) area were associated with higher risk of incident adenoma (hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.00–1.46 for change per 10 cm2 increase; HR 1.79, 95% CI 1.08–2.97 for highest vs lowest quartile, P values for trend = 0.045). Likewise, increasing changes in VAT area were independently associated with a higher risk of recurrent adenoma (HR 1.35, 95% CI 1.13–1.62 for change per 10 cm2 increase; HR 1.62, 95% CI 1.04–2.52 for highest vs lowest quartile, P values for trend = 0.001). Changes in subcutaneous adipose tissue area were not independently associated with CRA.

Conclusion

Increasing changes in VAT area were longitudinally associated with a higher risk of incident and recurrent CRA, independent of risk factors, suggesting that visceral adiposity may be an important target in CRA prevention.
Small and large fiber sensory polyneuropathy in type 2 diabetes: Influence of diagnostic criteria on neuropathy subtypes
Authors: Itani Mustapha , Gylfadottir Sandra Sif , Krøigård Thomas , Kristensen Alexander Gramm , Christensen Diana Hedevang , Karlsson Pall , Möller Sören , Andersen Henning , Tankisi Hatice , Nielsen Jens Steen , Jensen Troels Staehelin , Thomsen Reimar Wernich , Finnerup Nanna Brix , Sindrup Søren Hein
Published: December 2020

Diabetic polyneuropathy (DPN) can be classified based on fiber diameter into three subtypes: small fiber neuropathy (SFN), large fiber neuropathy (LFN), and mixed fiber neuropathy (MFN). We examined the effect of different diagnostic models on the frequency of polyneuropathy subtypes in type 2 diabetes patients with DPN. This study was based on patients from the Danish Center for Strategic Research in Type 2 Diabetes cohort. We defined DPN as probable or definite DPN according to the Toronto Consensus Criteria. DPN was then subtyped according to four distinct diagnostic models. A total of 277 diabetes patients (214 with DPN and 63 with no DPN) were included in the study. We found a considerable variation in polyneuropathy subtypes by applying different diagnostic models independent of the degree of certainty of DPN diagnosis. For probable and definite DPN, the frequency of subtypes across diagnostic models varied from: 1.4% to 13.1% for SFN, 9.3% to 21.5% for LFN, 51.4% to 83.2% for MFN, and 0.5% to 14.5% for non‐classifiable neuropathy (NCN). For the definite DPN group, the frequency of subtypes varied from: 1.6% to 13.5% for SFN, 5.6% to 20.6% for LFN, 61.9% to 89.7% for MFN, and 0.0% to 6.3% for NCN. The frequency of polyneuropathy subtypes depends on the type and number of criteria applied in a diagnostic model. Future consensus criteria should clearly define sensory functions to be tested, methods of testing, and how findings should be interpreted for both clinical practice and research purpose.
‘You become their advocate’: The experiences of family carers as advocates for older people with dementia living in residential aged care
Authors: Fetherstonhaugh Deirdre , Rayner Jo‐Anne , Solly Kane , McAuliffe Linda
Published: December 2020

Aims

The aim of this study was to identify features of well‐performing residential aged care services (RACS) as experienced by family carers.

Background

Family carers can have an integral role in residential aged care providing social support and are well‐placed to engage with staff and monitor care.

Design

A qualitative descriptive design was used. Semi‐structured face‐to‐face and telephone interviews were conducted with family carers of current or past residents of Australian RACS between November 2018 and January 2019. Interview transcripts were analysed thematically.

Results

Rather than reporting features of well‐performing RACS, participants shared stories of sub‐standard care, dysfunctional management and poor resident–staff–family interactions. An overarching theme emerged of ‘having to be an advocate’ for residents’ needs, which covered four major categories: organisational accountability (including transparency and individualised care), good communication, connection and trust. Combined, these constitute what carers perceive are the necessary conditions for determining the features of a well‐performing RACS.

Conclusion

Family carers need to feel confident and trust RACS staff when they hand over the role of carer for their relative with dementia.

Relevance to clinical practice

This study provides insight into the needs and challenges of family carers when they relinquish the care of an older relative with dementia. Strategies to build confidence and trust between RACS and family carers are essential. Aged care nurses can play a pivotal role to support this through the development of open communication and relational connections with residents and their families.
Hospital healthcare professionals' knowledge of dementia and attitudes towards dementia care: A cross‐sectional study
Authors: Zhao Wenhong , Moyle Wendy , Wu Min‐Lin Winnie , Petsky Helen
Published: December 2020

Aims and objectives

To explore hospital healthcare professionals' knowledge and attitudes towards dementia care in China.

Background

Hospital healthcare professionals deliver most diagnosis and treatment for people with dementia in China. Literature shows that healthcare professionals' knowledge and attitudes are of great importance in providing optimum dementia care. However, there is limited research of healthcare professionals' dementia knowledge and attitudes within hospital contexts in China.

Design

A cross‐sectional survey was conducted between April and December 2019.

Methods

A self‐report questionnaire composed of demographics and knowledge and attitude scales related to dementia was used for doctors and registered nurses working in settings where people with dementia are cared for in eleven public tertiary hospitals in Hebei Province, China. The STROBE checklist was adhered to in this study.

Results

In total, 603 healthcare professionals completed the study. The majority of respondents were registered nurses (71.3%). The overall mean knowledge score was 20.7 (SD = 2.9) out of a maximum possible score of 30. The overall mean score for attitudes was 91.3 (SD = 15.9) out of a maximum possible score of 140. Standard multiple linear regression analysis revealed that the highest level of education, the experience of searching for dementia‐related information and willingness to receive dementia training or education were significant predictors of knowledge scores. The department, the experience of working with people with dementia, length of dementia care, interest in dementia care and training type were significant predictors of attitude scores.

Conclusions

Deficits in the knowledge of dementia and a low level of positive attitude were identified among the healthcare professionals who work in hospital settings where people with dementia are cared for in China.

Relevance to clinical practice

Education and training in dementia care should be integrated into undergraduate nursing and medical programmes and provided for healthcare professionals after commencing employment.
The Slave House as Symbolic Artifact
Authors: Albert Taneshia W. , Tan Lindsay
Published: December 2020

The Slave House on Gorée Island is a sacred, spiritual mecca representing the transformational passage of descendants whose ancestors were displaced from continental Africa through the Trans–Atlanta slave trade. This visual essay presents an autoethnographic exploration—including first person narrative voice—to discuss spaces, places, and architectural structures central both to the Slave House as an architectural structure and to the context of Black identity. The structure, we argue, speaks of architectural beatification by Black ancestral spirits at a critical cultural moment of cultural diasporic creation and displacement of spirit and identity. It acts as a witness to the trauma of ancestral separation, the cultural memory transmitted through every taken step, and the common experience of displacement and identity that emotionally connects the present with the past.
Increased child abuse in Uganda amidst COVID‐19 pandemic
Authors: Sserwanja Quraish , Kawuki Joseph , Kim Jean H
Published: December 2020

Globally, COVID‐19 lockdown measures have exposed children to more sexual, physical and emotional abuse and neglect. Although the COVID‐19 pandemic is likely to have long‐lasting adverse psychological effects on children, there have been comparatively few studies on children's health as compared with adults, particularly in low‐income countries. Uganda implemented one of the most stringent lockdowns with bans on transportation and gatherings as well as the closure of schools, stores and places of worship. In order to address the dearth of information in less developed regions, the article aims to provide an insight into the increased cases of child abuse in Uganda during the COVID‐19 pandemic. The data and information were primarily compiled from government and child welfare organisation open‐source databases. The psychosocial impacts of COVID‐19 have greatly disrupted the living conditions of children, limiting their access to basic needs such as food and health care. In addition, there is a lack of social support, thus putting children at an increased risk of different forms of child abuse. Since the implementation of the COVID‐19 lockdown in Uganda, there has been a rise in the incidence of child abuse. Increased cases of physical and sexual abuse against children have been reported in different parts of the country as well as increased cases of child labour. To strengthen child protection during the COVID‐19 pandemic, this article highlights a need for multi‐level stakeholder cooperation to ensure increased funding, increased community awareness and sensitisation, early detection and effective management and referral of child abuse cases.
Integrating a chemical fungicide and Bacillus subtilis BIOUFLA2 ensures leaf protection and reduces ear rot (Fusarium verticillioides) and fumonisin content in maize
Authors: Guimarães Rafaela Araújo , Zanotto Edgar , Perrony Paul Esteban Pherez , Zanotto Lidia Almeida Salum , da Silva Leonardo José , Machado José da Cruz , Pinto Felipe Augusto Moretti Ferreira , Medeiros Henrique Novaes , von Pinho Renzo Garcia , de Melo Itamar Soares , da Silva Júlio Carlos Pereira , de Medeiros Fernanda Carvalho Lopes , de Medeiros Flávio Henrique Vasconcelos
Published: December 2020

Fungicides in maize production under tropical conditions reduce losses from foliar diseases, but only a few reduce ear rot incidence or mycotoxin contamination in kernels. Biocontrol agents (BCAs) may reduce postharvest losses but their efficacy has not been demonstrated in field conditions. Here, we evaluated the use of bacterial isolates in tandem with fungicides on Fusarium verticillioides incidence and fumonisin content. After an early screening, Bacillus subtilis and Streptomyces araujoniae isolates were used in field trials. Maize plants were sprayed twice: at the end of the vegetative stage (V9) and at the beginning of the reproductive stage (R1). Sprays were made by applying water, B. subtilis strain BIOUFLA2, S. araujoniae strain ASBV‐1T, or fungicide (cyproconazole + azoxystrobin) in different combinations, totalling nine treatments. Ten days later, all maize ears were inoculated with F. verticillioides. Plants were assessed for foliar diseases, grain yield, F. verticillioides incidence and fumonisin content in kernels. The treatment with two fungicide sprays reduced most of the foliar diseases but not F. verticillioides incidence in kernels. Twice‐sprayed B. subtilis and S. araujoniae reduced F. verticillioides, but did not protect leaves against other pathogens. All treatments encompassing a fungicide followed by one of the BCAs reduced F. verticillioides incidence compared to control. Twice‐sprayed fungicide increased fumonisin by 50% compared to water control, while fungicide followed by B. subtilis decreased the fumonisin content by 40%. Replacing the second chemical spray with S. araujoniae did not reduce the fumonisin content but provided a higher yield than a twice‐sprayed fungicide. Exclusive use of chemical fungicides may not ensure higher grain quality and yield, but the integration with B. subtilis BIOUFLA2 can accomplish both.
The lesbian, gay, bisexual and transgender communities' mental health care needs and experiences of mental health services: An integrative review of qualitative studies
Authors: Rees Samuel N. , Crowe Marie , Harris Shirley
Published: December 2020

Accessible summary

What is known on the subject?

There is evidence that the LGBT communities experience greater health disparities, particularly in relation to their mental health needs.

The LGBT communities are often faced with stigma and discrimination within mental health services.

What the paper adds to existing knowledge?

People within the LGBT communities have identified that their experiences of mental health services reinforce stigma and lack an understanding of their specific needs.

Their needs can be addressed by mental health services that challenge heteronormative assumptions and promote self‐acceptance and equity.

What are the implications for practice?

The existing heteronormative culture in mental health nursing practice needs to be challenged.

Practice needs to demonstrate self-awareness of personal and societal LGBT biases, prejudices, and stigma.

Practice needs to demonstrate knowledge of important LGBT health care and psychosocial issues.

Practice needs to reflect LGBT clinical skills grounded in professional ethics, guidelines, and standards of care.

Introduction

The lesbian, gay, bisexual and transgender (LGBT) communities are a minority population that experience a range of health disparities, including mental health. Because these groups have higher rates of mental disorder than the general population it is, therefore, pertinent to identify their specific mental health needs and their experiences when accessing mental health care.

Aim

To identify the mental health needs of the LGBT communities and their experiences of accessing mental health care.

Methods

An integrative review of qualitative studies was conducted.

Results

A total of fourteen studies were selected for this review. The studies identified that participants’ experiences of accessing mental health care were related to (a) experiencing stigma and (b) staff's lack of knowledge and understanding of LGBT people's needs. They identified a need for mental health care that promotes the principles of equity, inclusion and respect for diversity.

Discussion

The LGBT communities while not a homogenous group, face unique challenges when dealing with their mental health needs. Services that promote health equity and self‐acceptance are important for this group.

Implications for practice

It is vital that mental health nursing education incorporate models that promote equity, inclusion and respect for diversity regarding this group of people.
Effect of ET‐A blockade on portal pressure and hepatic arterial perfusion in patients with cirrhosis: A proof of concept study
Authors: Zipprich Alexander , Gittinger Fleur , Winkler Matthias , Dollinger Matthias M. , Ripoll Cristina
Published: December 2020

Background/aim

Endothelin causes vasoconstriction via the endothelin‐A receptor (ET‐A) in the intrahepatic circulation in cirrhosis and its increase leads to portal hypertension. The aim of the study was to investigate the acute effect of a selective ET‐A antagonist in patients with portal hypertension and cirrhosis.

Methods

Proof‐of‐concept study with two different substudies: (a) local intrahepatic administration of the ET‐A antagonist BQ 123 and (b) systemic oral administration of the ET‐A antagonist Ambrisentan. Portal pressure was determined by hepatic venous pressure gradient (HVPG, both substudies) and hepatic arterial blood flow (HABF) by intra‐arterial Doppler measurements (substudy 1) before and under the ET‐A antagonist. Systemic haemodynamic parameters were measured in substudy 2.

Results

Twelve patients (Child‐Pugh [CP] B/C n = 7/5) were included in substudy 1 and 14 patients (CP A/B/C n = 4/6/4) in substudy 2. The relative decrease in HVPG was −12.5% (IQR: −40% to 0%; P = .05) in substudy 1 and −5.0% (IQR: −11.5% to 0%; P = .01) in substudy 2. Substudy 1 revealed higher decrease in HVPG in CP B patients. HABF increased significantly and patients without portal pressure decrease showed a higher increase of HABF. Substudy 2 showed a slight decrease in the mean arterial pressure without changes of other systemic haemodynamic parameters.

Conclusion

Administration of a selective ET‐A antagonist decreases the portal pressure in cirrhotic patients. This decrease was higher in CP B patients and the non‐responders showed a higher increase in hepatic arterial flow. Selective ET‐A antagonists might be a future treatment option in patients with portal hypertension.
Nutrition‐sensitive agriculture programme impacts on time use and associations with nutrition outcomes
Authors: van den Bold Mara , Bliznashka Lilia , Ramani Gayathri , Olney Deanna , Quisumbing Agnes , Pedehombga Abdoulaye , Ouedraogo Marcellin
Published: December 2020

Success of nutrition‐sensitive agriculture programmes targeted to women may be influenced by increased demands on women's and other household members' time and by time‐related trade‐offs to accommodate programme participation. However, evidence of how such programmes impact time use and whether changes in time‐related demands negatively influence maternal or child health and nutrition outcomes is limited. This paper examines the impact of Helen Keller International's Enhanced Homestead Food Production programme in Burkina Faso (2010–2012) on women's and men's time use and associations between changes in women's time use and maternal and child health and nutrition outcomes. We used quantitative data from a cluster‐randomized controlled trial (baseline 2010, endline 2012) and qualitative data from two rounds of process evaluation (2011, 2012). Two‐stage analyses were used to first assess programme impacts on women's and men's time use using difference‐in‐difference impact estimates and second to evaluate whether programme impacts on women's time use were associated with changes in women's and children's health and nutrition outcomes. Programme impacts were considered significant if correctedP< 0.01, and associations were considered significant ifp< 0.05 andp <0.01. Qualitative data were analysed through manual coding and by calculating the means and standard deviations for the time spent by women and men on activities in intervention and control groups. Findings show that the programme significantly increased the amount of time women spent on agriculture in the intervention compared to the control group, but this was not associated with changes in maternal or child health or nutrition outcomes. Process evaluation data supported these findings.
The tip of the iceberg: Genome wide marker analysis reveals hidden hybridization during invasion
Authors: Rosinger Hanna S. , Geraldes Armando , Nurkowski Kristin A. , Battlay Paul , Cousens Roger D. , Rieseberg Loren H. , Hodgins Kathryn A.
Published: December 2020

Biological invasions are accelerating, and invasive species can have large economic impacts as well as severe consequences for biodiversity. During invasions, species can interact, potentially resulting in hybridization. Here, we examined two Cakile species, C. edentula and C. maritima (Brassicaceae), that co‐occur and may hybridize during range expansion in separate regions of the globe. Cakile edentula invaded each location first, while C. maritima established later, apparently replacing the former. We assessed the evidence for hybridization in western North America and Australia, where both species have been introduced, and identified source populations with 4561 SNPs using Genotype‐by‐Sequencing. Our results indicate that C. edentula in Australia originated from one region of eastern North America while in western North America it is probably from multiple sources. Cakile maritima in Australia is derived from at least two different parts of Europe while the introduction in western North America is from one. Although morphological evidence of hybridization is generally limited to mixed species populations in Australia and virtually absent elsewhere, our genetic analysis revealed relatively high levels of hybridization in Australia (58% hybrids using Admixture) and supported the presence of hybrids in western North America (16% hybrids using Admixture) and New Zealand. Hybrids might be commonly overlooked in invaders, as identification based solely on morphological traits may represent only the tip of the iceberg. Our study reveals a repeated pattern of invasion, hybridization and apparent replacement of one species by another, which offers an opportunity to investigate the role of hybridization and introgression during invasion.
Molecular identification and antifungal susceptibility among clinical isolates of dermatophytes in Shiraz, Iran (2017‐2019)
Authors: Zareshahrabadi Zahra , Totonchi Alireza , Rezaei‐Matehkolaei Ali , Ilkit Macit , Ghahartars Mehdi , Arastehfar Amir , Motamedi Marjan , Nouraei Hasti , Sharifi Lari Milad , Mohammadi Tooba , Zomorodian Kamiar
Published: December 2020

Dermatophytosis is a common superficial mycotic infection affecting individual's quality of life worldwide. The present study aimed to perform species‐level identification and evaluate the antifungal susceptibility patterns of dermatophytes isolated in Shiraz, Iran. This cross‐sectional study was conducted on clinical samples collected during 2017‐2019 from 307 patients suspected of having dermatophytosis. The isolates were identified by direct microscopy, culture and internal transcribed spacer ribosomal DNA sequencing, and their antifungal susceptibility patterns were determined by the microdilution method. Among 307 patients, dermatophytosis was diagnosed by microscopy in 190 (61.8%) subjects and confirmed in 130 (42.3%) cases by both microscopy and culture. It was found out tinea pedis was the most common clinical manifestation, and Trichophyton mentagrophytes was the most prevalent species (28.4%), followed by T tonsurans (23.8%), Microsporum canis (11.5%), T interdigitale (10%), T verrucosum (6.9%), T rubrum (6.9%), T benhamiae (4.6%), T violaceum (3%), T simii (3%), Epidermophyton floccosum (0.7%) and M ferrugineum (0.7%). Moreover, it was revealed that luliconazole with a geometric mean (GM) minimum inhibitory concentration (MIC) of 0.03 μg ml‐1 was the most effective agent against all tested isolates. Regardless of species, 30% of isolates responded to high MICs of griseofulvin (MIC90 > 2 μg ml‐1). The increasing prevalence of nonindigenous species of T simii, T benhamiae and M ferrugineum in Shiraz, Iran, was a notable finding. In addition, infections due to zoophilic species showed an increasing trend. These epidemiological data, along with antifungal susceptibility patterns, may have implications for clinical decision‐making and successful treatment.
Nicotiflorin attenuates cell apoptosis in renal ischemia‐reperfusion injury through activating transcription factor 3
Authors: Wang Lin , Li Chenyu , Guan Chen , Zhang Yue , Yang Chengyu , Zhao Long , Luan Hong , Zhou Bin , Che Lin , Wang Yanfei , Zhang Wei , Zhang Hui , Man Xiaofei , Jiang Wei , Xu Yan
Published: December 2020

Introduction

Nicotiflorin is the main characteristic component of Nymphaea candida, which is a natural product that reportedly ameliorates acute injury of the liver and cerebral cortex, but the effect of nicotiflorin on acute kidney injury (AKI) remains unknown. This study aimed to investigate the effects of nicotiflorin on ischaemia/reperfusion (I/R) AKI and the associated mechanisms.

Methods

We performed both (a) in vivo experiments with C57BL/6 mice with bilateral renal pedicles clamped for 45 minutes and (b) in vitro experiments with human kidney epithelial cells (HK‐2) exposed to hypoxia/reoxygenation to mimic I/R injury to study the role of nicotiflorin in AKI.

Results

In vivo, nicotiflorin administration exerted protective effects on renal injury, as demonstrated by reductions in the levels of caspase3 and Bad (P < .05), the upregulation of Bcl‐2 expression (P < .05) and improved renal histologic changes, which suggested that nicotiflorin can alleviate I/R injury and cell apoptosis. In vitro, nicotiflorin at a concentration of 75 μg/mL protected cells from hypoxia, which further confirmed that nicotiflorin exerts beneficial effects on hypoxia/reoxygenation. Through computational molecular docking, we found that activating transcription factor 3 (ATF3) exhibits a robust interaction with nicotiflorin with a simulated binding energy of −9.2°. We verified the interaction of nicotiflorin with ATF3 in HK‐2 cells, and found that nicotiflorin reduced the apoptosis of HK‐2 through ATF3.

Conclusion

Based on the above‐described results, nicotiflorin appears to have a beneficial impact on deteriorated renal function, as demonstrated using an experimental I/R model. The underlying mechanisms of nicotiflorin might inhibit HK‐2 cell apoptosis through ATF3.
Overlap of functional heartburn and reflux hypersensitivity with proven gastroesophageal reflux disease
Authors: Rengarajan Arvind , Pomarat Margaux , Zerbib Frank , Gyawali C. Prakash
Published: December 2020

Background

When esophageal acid exposure time (AET) is physiologic, ROME IV stratifies functional esophageal disorders into functional heartburn (FH, with negative reflux‐symptom association) and reflux hypersensitivity (RH, with positive reflux‐symptom association), and hypothesizes that FH/RH could overlap with proven gastroesophageal reflux disease (GERD). We compared conventional FH/RH diagnosed off antisecretory therapy with overlap FH/RH coexisting with proven GERD.

Methods

Adult patients with heartburn underwent pH‐impedance testing on therapy (proven GERD) and off therapy (unproven GERD) and completed validated questionnaires defining symptoms (Reflux Diagnostic Questionnaire, RDQ), affective state (Hospital Anxiety and Depression Scale, HADS; Visceral Sensitivity Index, VSI), and functional diagnoses (irritable bowel syndrome, IBS; functional dyspepsia, FD on ROME diagnostic questionnaire). AET (pathologic: >6%, physiologic <4%) and mean nocturnal baseline impedance (MNBI) were calculated. Clinical, psychological, and functional profiles were compared between FH and RH and to a comparison cohort of non‐erosive reflux disease (NERD, AET > 6%).

Key Results

Study patients included 19 with RH (10 with overlap RH), 60 with FH (31 with overlap FH), and 26 patients with NERD. Clinical, psychological, and functional profiles of conventional FH/RH were similar to overlap FH/RH. Compared with NERD, combined FH and RH cohorts had higher anxiety scores, and lower proportions with IBS. Compared with FH with low MNBI, FH defined using both normal AET and normal MNBI had higher depression scores (p = 0.008), and trended toward higher anxiety scores (p = 0.059).

Conclusions and Inferences

Conventional and overlap FH and RH have similar clinical, psychological and functional profiles, thereby proving ROME IV hypotheses.
Pediatric teledermatology: A review of the literature
Authors: Cartron Alexander M. , Aldana Paola C. , Khachemoune Amor
Published: December 2020

Skin complaints are common among pediatric patients, yet as of 2020, fewer than 400 board‐certified pediatric dermatologists currently practice in the United States. Pediatric teledermatology may address barriers to dermatologic care in children, assisting with distant geographic locations and long wait times. A review of the literature was conducted to synthesize important features of teledermatology for pediatric dermatologists. We summarize types of telemedicine platforms, common dermatologic conditions seen by pediatric teledermatologists, diagnostic accuracy and concordance, and guidelines from the American Academy of Dermatology and the American Telemedicine Association regarding teledermatology. This report highlights the utility of pediatric telemedicine in both the outpatient and inpatient dermatology setting to increase access to high‐quality dermatologic care.
Shadows and shields: Stars limit their collaborators’ exposure to attributions of both credit and blame
Authors: Kehoe Rebecca R. , Bentley F. Scott
Published: December 2020

Building on the notion of cumulative advantage, we undertake a nuanced examination of how collaborating with a star affects attributions of credit and blame to nonstars in collaborative endeavors. Situating our inquiry in the US hedge fund industry, we hypothesize two‐way interactions predicting that collaboration with a star comanager will weaken both the positive effect of comanaged fund success and the negative effect of comanaged fund failure on nonstar managers’ professional status attainment (i.e., the status of a manager's subsequent employing firm). Specifically, we argue that the involvement of a star comanager will weaken prospective employers’ attributions for positive or negative performance to a focal nonstar manager, due to presumptions of the star's disproportionate influence in collaborative decisions. We then theorize a series of three‐way interactions specifying the roles of other signals of a nonstar manager's competence in this process. More precisely, we argue that a nonstar's performance outside the collaborative context and the status of the nonstar's current employer will weaken the dampening effect of comanaging with a star in the context of success and strengthen the favorable, blame‐reducing effect of comanaging with a star in the context of failure. Therefore, we suggest that nonstars who can signal their competence with these independent status signals will achieve greater professional status attainment than will those lacking such signals following both collaborative success and collaborative failure with a star. Our primary analyses support our hypotheses, while our supplementary analyses offer corroborative support for theorized mechanisms and evidence to address alternative explanations.
The role of trait anxiety in attention and memory‐related biases to threat: An event‐related potential study
Authors: Berggren Nick , Eimer Martin
Published: December 2020

Threat‐related information strongly competes for attentional selection, and can subsequently be more strongly represented within visual working memory. This is particularly the case for individuals reporting high trait anxious personality. The present study examined the role of anxiety in both attention and memory‐related interactions with threat. We employed a hybrid working memory/visual search task, with participants preselected for low and high anxious personality traits. They selected and memorized an emotional face (angry or happy) appearing together with a neutral face in encode displays. Following a delay period, they matched the identity of the memorized face to a probe display item. Event‐related markers of attentional selection (N2pc components) and memory maintenance during the delay period (i.e., CDA) were measured. Selection biases toward angry faces were observed within both encode and probe displays, evidenced by earlier and larger N2pcs. A similar threat‐related bias was also found during working memory maintenance, with larger CDA components when angry faces were stored. High anxious individuals showed large selection biases for angry faces at encoding. For low anxious individuals, this bias was smaller but still significant. In contrast, only high anxious individuals showed larger CDA components for angry faces. These results suggest that threat biases in attentional selection are modulated by trait anxiety, and that threat biases within working memory may only be present for high anxious individuals. These findings highlight the key role of individual differences in trait anxiety on threat‐related biases in visual processing, especially at the level of working memory maintenance.
The impact of minimum wages on wages, wage spillovers, and employment in China: Evidence from longitudinal individual‐level data
Authors: Fang Tony , Gunderson Morley , Lin Carl
Published: December 2020

We utilize the substantial variation in both the magnitude and frequency of minimum wage changes that have occurred in China since its new minimum wage regulations in 2004 to estimate their impact on wages, wage spillovers, and employment. We use county‐level minimum wage data merged with individual‐level longitudinal data from the Urban Household Survey for the period 2004–2009, spanning the period after the new minimum wage regulations were put in place. Our results indicate that minimum wage increases raise the wages of otherwise‐low‐wage workers by a little less than half (41%) of the minimum wage increases. Depending on the specification, these wage effects also lead to a 2–4 percentage point reduction in the probability of being employed, with a 2.8 percentage point reduction being our preferred estimate. We also find statistically significant but very small wage spillovers for those whose wages are just above the new minimum wage, but they are effectively zero for those higher up in the wage distribution.