bluuebunny/crossref_metadata_2025 huggingface dataset:
Circulating immune complexes in a patient with prolonged gonococcal septicemia
Authors: Danielsson D , Norberg R , Svanbom M.
Published: July 2023

A case of prolonged gonococcal speticemia is presented. Lack of genital symptoms, of demonstrable gonococcal antibodies in whole serum, and initially also of skin lesions contributed to a delayed diagnosis that was finally confirmed by positive blood culture. Evidence of circulating immune complexes was obtained by the demonstration of gonococcal IgG antibodies after dissociation of serum by gradient centrifugation of pH 4.0. The possibility that circulating immune complexes may contribute to the symptomatology of gonococcal septicemia is pointed out.
Embryology of the epidermis: ultrastructural aspects. II. Period of differentiation in the mouse with mammalian comparisons
Authors: Weiss LW , Zelickson AS.
Published: July 2023

A detailed light and electron microscopic study of the cellular morphology of the epidermis in the 13 through 16 day mouse fetus reveals that an occasional intermediate cell is interposed between the basal and peridermal layers on day 13. All layers are mitotically active. Tonofilaments, unassociated with desmosomes, are present within the basal cell cytoplasm and the mitotic axis of the basal cells has changed from a parallel to a perpendicular plane with respect to the epidermal surface. At 14 days, a complete stratum intermedium, composed of one or two cell layers, is present. Rarely, developing hemidesmosomes are observed. Pools of glycogen are present in all cells below the periderm. The periderm is dense and no longer mitotically active. The skein of filaments, present in the inferior cytoplasmic region of the basal cells on days 12 and 13, is now absent. In the 15 day fetus, numerous developing hemidesmosomes are present. The stratum intermedium contains three to four layers of cells, and filaments are located deep within the cytoplasm of these intermediate cells. Rarely, a few developing keratohyalin granules and keratinosomes are present. A stratum intermedium is no longer present in the 16 day fetus. This region is now composed of a stratum spinosum and a stratum granulosum. Numerous keratinosomes are located in the upper stratum spinosum and lower stratum granulosum. The cells in the stratum granulosum are nucleated and the uppermost cells contain large keratohyalin granules. Three heterogeneous and one homogeneous type of keratohyalin granule is described. Dense bodies are present within mitochondria, nuclei, glycogen pools and the peridermal cytoplasm. The periderm is no longer dense and glycogen and keratohyalin granules are not observed in this layer.
Alteration in the surface morphology of synchronized B-16 melanoma cell during the cell cycle
Authors: Sauk Jr JJ , White JG , Witkop Jr CJ
Published: July 2023

B-16 melanoma cells were synchronized for G1-S periods by mitotic shake-off and S-G2 periods by thymidine block. The surface morphology of the B-16 melanoma at low density partially confluent culures revealed that, as in other cell systems investigated, the surface morphology could be correlated with four periods to cell cycle: G1, S, G2 and M. G1 cells were rounded and possessed microvilli, blebs and ruffles (late G1). During S period, blebs and microvilli diminished and disappeared, but ruffles were more evident. Late G2 cells acquired microvilli, surface blebs, and extended filopodia and began to thicken and round themselves for mitosis.
B lymphocytes, T lymphocytes and phytohaemagglutinin responsiveness in atopic dermatitis
Authors: Andersen E , Hjorth N.
Published: July 2023

The spontaneous binding of sheep erythrocytes to human lymphocytes with the formation of rosettes was used as a measure of thymus-derived lymphocytes and the rosette formation with complement-coated sheep erythrocytes as a measure of bursa-dependent lymphocytes in the peripheral blood of patients with atopic dermatitis. Both percentage proportion and the absolute number of thymus-derived lymphocytes were slightly but significantly reduced. In a few patients with atopic dermatitis the percentage and absolute number of bursa-dependent lymphocytes were increased. However, when all values were considered, no significant differences were demonstrated. The responsiveness of cultured lymphocytes to phytohaemagglutinin was normal when the culture medium contained foetal calf serum. The response of normal lymphocytes was not impaired by serum from patients with atopic dermatitis. However, the response was depressed when atopic dermatitis lymphocytes were cultured in medium containing autologous serum, indication that a partial lymphocyte defect becomes manifest only in the presence of a serum factor, presumably IgE.
Irradiation of epidermal cell suspensions in the presence and absence of protoporphyrin
Authors: Van Gog H.
Published: July 2023

Abstract is not availeble.
The role of langerhans cells in contact allergy. I. An ultrastructural study in actively induced contact dermatitis in guinea pigs
Authors: Silberberg I , Baer RL , Rosenthal SA.
Published: July 2023

Abstract is not availeble.
Studies on experimental itch induced by kallikrein and bradykinin
Authors: Hägermark O.
Published: July 2023

Abstract is not availeble.
Ultrastructural features of mast cells in systemic mastocytosis
Authors: Naveh Y , Ludatscher R , Gellei B , Haim S , Friedman A.
Published: July 2023

A 3-year-old boy with systemic mastocytosis has been observed since the age of 4 months when he was first diagnosed as suffering from urticaria pigmentosa. Involvement of skin, liver, spleen and bones was observed. The electron microscopy of skin and liver revealed varied alterations in the morphology of mast cells. The most important findings were irregularly-shaped cells and unusual long and interdigitated cytoplasmic villi, with consequent aggregation of mast cells which was more prominent in the dermis. Proliferation and accumulation of mitochondria in one part of the cell and deeply indented nuclei were frequent. The problem, whether the morphological changes encountered--especially the complex interdigitation of villi--should be interpreted as a sign of expected neoplastic development, is discussed.
Circulating Langerhans cells in a dermal vessel
Authors: Silberberg I , Baer RL , Rosenthal SA.
Published: July 2023

Abstract is not availeble.
Large doses of glucocorticoid in the treatment of alopecia areata
Authors: Burton JL , Shuster S.
Published: July 2023

Severe extensive alopecia areata (totalis) was treated with prednisolone as a single 2 g dose i.v. (22 patients) or 0.5 g daily for 5 days orally (13 patients). Four of the patients responded well, 12 had a poor response and 19 had no response. There was a relapse in some at about 6 months, which could be arrested by a further single i.v. dose, but the risks of this form of therapy are unclear and it cannot be recommended for general use. The clinical response to a single dose of corticosteroid implies, however, that there may be a 'switch' mechanism in certain auto-immune diseases, with an all-or-none response.
Auto-immune atrophic gastritis in patient with dermatitis herpetiformis
Authors: Stockbrügger R , Andersson H , Gillberg R , Kastrup W , Lundquist G , Mobacken H.
Published: July 2023

Seventeen patients with dermatitis herpetiformis were tested for gastric hydrochloric acid secretion. Seven were found to be achlorhydric. Atrophic gastritis in these patients probably had an auto-immune pathogenesis, as judged by elevated serum gastrin level, high prevalence of antibodies against gastric parietal cells and antrum sparing of the gastric atrophy. This type of atrophic gastritis is considered to indicate a precursor state to pernicious anemia.
Ultrastructure of localized myxedema
Authors: Kobayasi T , Danielsen L , Asboe-Hansen G.
Published: July 2023

Five biopsies from three patients with localized myxedema were studied by electron microscopy. The dermis showed an overwhelming accumulation of microfibrils with knobs (acid glycosaminoglycans) and an amorphous material containing glycoprotein. Furthermore, evidence of degradation without new formation of collagen fibrils was found. Considerable numbers of mast cells with various types of granules, fibroblasts with dilated granular endoplasmic reticulum, and macrophages were seen in the mucinous areas.
5-Fluoro-uracil cream in the successful treatment of therapeutically refractory condylomata acuminata of the urinary meatus
Authors: Von Krogh G.
Published: July 2023

A therapeutic trial of 5% 5-Fluoro-uracil in cream form was conducted in 40 men with condylomata acuminata unresponsive to other therapeutic measures. Sixty per cent of the condylomata on the genital and/or anal mucosa showed complete regression. The most promising results were recorded in the cases of condylomata affecting the urinary meatus. These lesions disappeared in 13 of 14 cases after an average of 3 weeks' treatment with subjectively few side effects. With regard to this type of condylomata it may be said that a great therapeutical advance has been achieved. The treatment of other condylomata involving the genital or anal mucosa often causes intolerable discomfort to the patients. The method should in these cases therefore be attempted only when the lesions prove to be refractory to other methods of treatment. In its present form the application of 5-FU cream is difficult to confine solely to the condylomata itself. The cream appears to have little or no effect on condylomata at sites other than the mucosa.
Letter: Treatment of psoriasis with oral psoralens and longwave ultraviolet light
Authors: Reed WB.
Published: July 2023

Abstract is not available.
Treatment of hereditary angioneurotic edema with tranexamic acid and cinnarizine
Authors: Ohela K.
Published: July 2023

Six out of 7 Finnish patients suffering from hereditary angioneurotic edema were helped during attacks, by treatment with tranexamic acid (AMCA, Cyklokapron, Kabi) in doses of 1.5 g 3 times daily, follow-up time 3-25 months. 3 of these patients also had continuous AMCA treatment, in the course of which 2 remained nearly symptom-free on a dosage of 1 g 2-3 times daily. Even the third one had shorter and milder attacks. One patient, however, had to stop taking AMCA after 6 weeks' treatment, because of fatigue and nausea. Follow-up time for the others was 9-11 months. For comparative purposes, 3 patients were given continuous treatment with an antihistamine, cinnarizine in a dosage of 20-30 mg daily. Two of the patients were helped by it, one becoming nearly symptom-free and the other having fewer and milder attacks; follow-up time 9-10 months.
Parallel studies on collagen hydroxyproline and hydroxylysine in human skin biopsies
Authors: Blumenkrantz N , Ullman S , Asboe-Hansen G.
Published: July 2023

Studies on hydroxyproline and hydroxylysine, the two amino acids characteristic of collagen and related glycoproteins, were undertaken on biopsies of pathologic and clinically normal human skin. No statistically significant differences between clinically normal skin of mamma, thorax, axilla, femur, hip and sacral area were found. A decreased collagen content was seen in chronic pemphigus (bullous pemphigoid), amyloidosis, scleromyxedema and the edge of a leg ulcer. Determination of both amino acids is considered necessary to characterize alterations of collagen.
Nodules on the legs. A clinical, histological and immunohistological study of 82 patients representing different types of nodular panniculitis
Authors: Niemi KM , Förström L , Hannuksela M , Mustakallio KK , Salo OP.
Published: July 2023

Eighty-two cases of nodular panniculitis of the legs were examined clinically, histologically and immunohistologically. Clinically the cases could be divided into four groups: typical erythema nodosum (ENty) (35 cases), erythema nodosum migrans (ENmi) (11 cases), erythema induratum (EI) (11 cases) and the remaining 25 cases not consistent with the others as "non-definite panniculitis" (NDP). The main histological categories were septal panniculitis and lobular panniculitis, the former including erythema nodosum, both typical and migrans, the latter EI and NDP. Lobular panniculitis was divided into three subgroups in which the most prominent histological features were epithelioid cell granuloma, vasculitis and palissading granuloma, respectively. Immunoglobulins in the vessel walls were found in 5 of the 46 cases of erythema nodosum, in 19 of the 36 EI and NDP cases and, in the histological groups in 4 of the 43 cases of septal panniculitis and in 19 of the 35 cases of lobular panniculitis, respectively. Fibrin was found in the walls of the papillary capillaries and deep dermal vessels in the majority of cases of lobular panniculitis. In EI and NDP the follow-up time was 40 months, on average. Twenty-two patients were treated with antituberculous drugs, 15 became symptomless, as did 5 of the 12 patients who were not treated at all.
Provocation with cow's milk and cereals in atopic dermatitis
Authors: Hammar H.
Published: July 2023

Oral provocation test with cow's milk and cereals were performed in 81 children with atopic dermatitis, all below 5 years of age. In 15 of the children exacerbation of the dermatitis occurred on the second or third day after initiation of the tests. These patients, whose mean age was 13 months, underwent repeated provocation during the ensuring 18 months. Eleven children lost their sensitivity to the offending foods and 2 children became more tolerant during this period. Initial levels of serum IgE and specific reagins against the foods tested did not distinguish those patients who were positive to the provocation tests. In this group, however, reagins against egg white were significantly increased. The specific serum reagins were unaltered or increased in the majority of cases during the period of study. The radioallergosorbent test (RAST) was found of limited value as a screening tool in patients with atopic dermatitis in whom exacerbation of the condition appears to be caused by food sensitivity.
Early changes in human epidermis following thermal burn: an electron microscopic study
Authors: Takigawa M , Ofuji S.
Published: July 2023

Early alterations in the epidermis of human volunteers following 60 degrees and 95 degrees C burns were studied by means of electron microscopy. The blister was induced at 30 seconds following a 60 degrees C burn for 1 and 3 minutes by disintegration of the basal cells just above the basement membrane, and, in addition, for 3 minutes by disruption of the intercellular bridges adjacent to the desmosomes in the suprabasal cells. The keratinocytes of the separated epidermis revealed intracytoplasmic vacuoles, widening of the intercellular spaces and, in some cells, vacuolization of the mitochondria. At 30 seconds following a 95 degrees C burn for 3 seconds, the blister was induced by complete breakage of the basal and suprabasal cells which demonstrated karyorrhexis, aggregated tonofibrils and breaks in the plasma membrane. The keratinocytes of the blister roof showed aggregation of the tonofibrils at the periphery, and vacuolization of mitochondria and endoplasmic reticulum. The desmosomes and basement membrane revealed no alterations with 60 degrees and 95 degrees C burns.
Tranexamic acid (Cyklokapron) in chronic urticaria: a double-blind study
Authors: Laurberg G.
Published: July 2023

A double-blind study with tranexamic acid (Cyklokapron) was carried out in 17 patients with chronic urticaria. All patients had slightly depressed C1-chronic esterase inhibitor value. No significant differences were found between TA and placebo treatment periods.
Silver-blue nails
Authors: Plewig G , Lincke H , Wolff HH.
Published: July 2023

The case is reported of a man with uniformly silver-blue discolouration of all fingernails, with deeper colouring over the lunulae. The nail bed changes resulted from the uncontrolled ingestion of a silver-containing granular powder. The total silver intake was over 15 g. The only other sign of argyrosis was a barely perceptible greyish discolouration over the cheeks and in the sclerae. Biopsies were taken from the nail bed and the cheek. Electron microscopy revealed metallic deposits in elastic fibres and basement membranes. The silver deposition was much heavier in the nail bed than in facial skin. Long-wave ultraviolet light (UVA) and lack of melanin protection seem to be responsible for this phenomenon. Argyrosis and the differential diagnosis of nail discolourations are reviewed.
Treatment of resistant psoriasis with oral 8-methoxypsoralen and longwave ultraviolet light (PUVA). A treatment schedule and a follow-up study
Authors: Weismann K , Howitz J , Bro-Jorgensen A.
Published: July 2023

Thirty-one patients with resistant psoriasis were treated with 8-methoxypsoralen orally, followed by irradiation with long-wave ultraviolet light (PUVA). The initial irradiance was 1.4 Joule/cm2, increased by 0.5 Joule/cm2 at the following exposures, to a maximum of 4.2 Joule/cm2. The 8-methoxypsoralen dosage was approximately 0.5 mg/kg body weight. In 17 patients psoriasis cleared completely after 10.8 +/- 3.4 exposures (mean +/- S.D.). In 12 patients the healing was almost complete after 14.5 +/- 5.8 exposures. Adverse effects were negligible. After clearing, the patients were followed without further therapy. Psoriasis recurred in approximately half of those patients followed for more than 2 months, on average 5 weeks after cessation of treatment. PUVA is an effective and agreeable therapy for recalcitrant psoriasis. Further studies must be carried out to evaluate the risks of a long-term treatment.
Lines of Beau: possible markers of zinc deficiency
Authors: Weismann K.
Published: July 2023

Abstract is not available
The effect of occlusion on carbon dioxide emission from human skin
Authors: King RD , Cunico RL , Maibach HI , Greenberg JH , West ML , Jeppsen JC
Published: July 2023

The effect of occlusion on the carbon dioxide (CO2) emission rate (CDER) of human skin was determined. Occlusive plastic tape elevated the CDER 4.5 times (90nl/cm2/hr) over the normal CDER (20nl/cm2/hr). This increase was noted within a 3-hour period. Non-occlusive paper tape had no effect on CDER. Quantitation of the amount of CO2 under plastic tape revealed that CO2 was present at a concentration of 8-10%. Removal of the plastic tape after 24 hours allowed the CDER to return to approximately normal values within 2 hours. The mechanism by which occlusive plastic tape mediates this dramatic effect on CDER as well as the significance of elevated CO2 concentrations under occlusion are discussed.
An exogenous variety of pseudoxanthoma elasticum in old farmers
Authors: Christensen OB
Published: July 2023

Cutaneous lesions clinically similar to and histopathologically indistinguishable from pseudoxanthoma elasticum have been observed in the cubital folds of nine elderly farmers. In all cases the skin lesions were ascribed to exposure to salpeter during fertilization on a single occasion decades previously. Signs of systemic pseudoxanthoma elasticum were absent.
Salpeter-induced dermal changes electron-microscopically indistinguishable from pseudoxanthoma elasticum
Authors: Nielsen AO , Christensen OB , Hentzer B , Johnson E , Kobayasi T
Published: July 2023

Salpeter-induced calcium deposits in ten patients showed a close clinical and histopathological similarity to the lesions of pseudoxanthoma elasticum. By electron microscopy and selected area diffraction analyses of the calcium deposits we find the changes indistinguishable from the changes previously described in involved skin of patients suffering from PXE. Clinically our patients were compared with the fourteen patients with traumatic calcification previously described.
Non-thrombocytopenic purpuras
Authors: Niemi KM , Kangas K
Published: July 2023

88 cases of microscopical diapedesis of the red blood cells in the superficial blood vessels of the skin were investigated clinically, histologically and immunohistologically. Polymorphonuclear vasculitis (PMNV) was found in 27 cases, 18 of which also demonstrated immunoglobulins (mostly IgM) in the vessel walls. Complement (C3) was found in 16 cases. The cases with PMNV formed a uniform group as regards preceding infections, drug consumption, clinical features, and pathological urinalysis and laboratory data. The second group consisted of 21 cases of lymphocytic perivasculitis with immunoglobulins and/or complement (LP + ig/C3). It clearly differed clinically from the former group in three respects:
Systemic miconazole treatment of a patient with chronic granulomatous mucocutaneous candidiasis
Authors: Blomqvist K , Horsmanheimo M
Published: July 2023

Miconazole given intravenously and orally was evaluated in the treatment of a patient with drug-resistant, chronic, widespread horny candida lesions. Marked clinical improvement occurred after 4 weeks of the first course of treatment, in which 400 mg of miconazole per day was given intravenously. After 3 months no signs of the disease were apparent. The patient remained free of symptoms for 3 months, after which the lesions recurred and a second course of treatment, with 200 mg of miconazole per day intravenously, was started. A prompt clinical clearing was seen within 3 weeks, after which the miconazole (1 000 mg per day) was given orally. During oral administration of the drug a limited degree of recurrence of horny patches occurred. Systemic miconazole seems to be the drug of choice in the treatment of systemic chronic mucocutaneous candidiasis.
The cellular infiltrate in contact hypersensitivity to picryl chloride in the mouse
Authors: Roupe G , Ridell B.
Published: July 2023

In the present work, the contact hypersensitivity skin test reaction to picryl chloride in CBA mice was examined. The test was performed by applying the contact allergen to the ear skin and making a series of histological analyses up to 24 hours after challenge. An increment in ear thickness, measured with an engineer's micrometer 24 hours after challenge, was obvious in a group of sensitized mice when compared with a nonsensitized control group, and the difference was found to be highly significant. One hour after challenge, mononuclear cells appeared in the dermis, increasing in numbers during the following 12 hours. At this time, neutrophil granulocytes were the dominant cells in the infiltrate and remained so up to 24 hours after challenge. On the basis of the experiments performed here we conclude that measuring of the ear swelling with a micrometer 24 hours after challenge is a useful and reliable test of contact sensitivity in the mouse.
In vivo and in vitro immune responses to trichophytin in dermatophytosis
Authors: Kaaman T , Petrini B , Wasserman J.
Published: July 2023

Cell-mediated immunity in patients with verified dermatophytosis was investigated by means of skin test and lymphocyte stimulation test (LST) using purified trichophytin, prepared by the ethylene glycol method, and commercially available trichophytin. The purified trichophytin seemed to be more specific and sensitive both in skin test and in LST. In the majority of cases skin-positive patients were also positive in LST, especially when T. mentagrophytes or E. floccosum was the causative organism. Patients with non-chronic infections also showed a close correlation between skin reactivity and LST. Patients with chronic mycosis or infected with T. rubrum, on the other hand, were often skin-negative. Their lymphocyte reactivity in vitro, however, was usually positive, thus showing a discrepancy in the ability of these two methods to measure cell-mediated immunity.
Dermatitis plantaris sicca: a retrospective study of children with recurrent dermatitis of the feet
Authors: Jepsen LV.
Published: July 2023

19 patients with recurrent dermatitis of the feet were re-examined in order to review the atopic predisposition, and the duration of the disease. 14 patients (74%) had a history of atopy, vis-√†-vis 31.5% in the control group. In 8 patients (42%) the dermatitis persisted beyond puberty, though in a clinically considerably milder condition.
Liver biopsy in PUVA-treated patients
Authors: Zachariae H , Kragballe K , Søgaard H.
Published: July 2023

Seventy-five liver biopsies were performed in 30 psoriatics and 5 patients with mycosis fungoides undergoing treatment with photochemotherapy with 8-methoxypsoralen and UVA light. All patients had pre- and post-PUVA biopsies, the latter after one year. Five psoriatics had a further biopsy after 2 1/2 years of treatment. No statistically significant differences were found between biopsies taken before and after treatment.
Effects of histamine receptor antagonists on histamine-induced responses in human skin
Authors: Hägermark O , Strandberg K , Grönneberg R.
Published: July 2023

The effects of intradermally administered histamine H1- and H2-receptor antagonists on the cutaneous responses--redness, weal, flare and itch--induced by intradermal injection of histamine were studied in man. Weal and redness were studied after blockade of the axon reflex by local infiltration with lidocaine. All responses were significantly inhibited by the H1-receptor antagonist mepyramine. The H2-antagonists cimetidine and metiamide reduced flare and itch significantly but not to the same extenet as mepyramine and not in a clearly dose-related manner. The size of weal and redness was not significantly reduced by cimetidine. No further reduction of flare, itch or weal was obtained by adding metiamide or cimetidine to mepyramine. After blockade of the axon reflex with lidocaine the histamine-induced weals turned white at the centre. This blanching was more prominent when histamine was injected in combination with cimetidine. Substituting mepyramine for cimetidine resulted in small weals with an intense red colour. It is concluded that, apart from being engaged in the direct vasodilatory response to histamine, H2-receptors do not seem to be involved in the other cutaneous responses to histamine studied.
Comparison of clobetasol propionate and betamethasone-17,21-dipropionate with reference to adrenal suppression
Authors: Eriksen K.
Published: July 2023

32 adult hospitalized patients with common skin disorders were controlled in a double-blind comparison study with clobetasol propionate (Dermovat) and betamethasone-17,21-dipropionate (Diproderm) with regard to adrenal suppression. The latter, when assessed by plasma cortisol, was significantly greater in the dermovat-treated groups after the 1st and 2nd week with daily treatment with both 25 g and 15 g ointment. Daily treatment of skin areas greater than 25% with 25 g Diproderm also showed clear adrenal suppression, whereas no such effect was obtained with daily treatment with 10 g Diproderm of skin areas greater than 15%. In all cases, plasma cortisol levels were normal 1--2 weeks after the end of topical treatment.
Adult human skin maintained in organ culture: I. The ultrastructure of the acellular compartment of connective tissue
Authors: Hentzer B , Kobayasi T.
Published: July 2023

Collagenolytic enzymes are produced by cultured skin explants. During cultivation the acellular compartment of the dermal connective tissues is digested away. The ultrastructure of the connective tissue resorption has been studied in human skin maintained in organ culture for 2--10 weeks. The connective tissue changes are: (1) Collagen fibrils with normal axial periodicity but decreasing diameters. On cross sections these fibrils have irregular outlines, while the longitudinal sections show fibrils separated into thin bundles of filaments 40--80 A thick with preserved normal axial periodicity. (2) Cross-banded filamentous aggregations (CBFA) consisting of fine parallel filaments 25 A thick and without axial periodicity. The CBFA has 350 A thick bands at 525 A intervals. At the end of the cultivation, the CBFA are replaced by solitary filaments 25 A thick. (3) The elastic fibres show no marked changes of the amorphous matrix, while the fibrils disappear. The loss of collagen and elastic fibrils during cultivation of the skin gives direct evidence of connective tissue degradation. The described changes are discussed in relation to previous ultrastructural studies on connective tissue resorption of various tissues.
Mixed bullous disease with labile erythrocyte sedimentation rate
Authors: Dahle JS , Tjora S , Daae LN , Wereide K.
Published: July 2023

A woman, aged 66, fulfilled all the usual criteria of dermatitis herpetiformis. Subsequently, she developed circulating IgA and IgM basement membrane zone antibodies, a labile erythrocyte sedimentation rate (ESR), and the clinical picture changed to one of bullous pemphigoid. Her labile ESR was obviously caused by a factor related to the erythrocytes. Direct Coombs test was positive.
Serum alkaline phosphatase activity in acrodermatitis enteropathica: an index of the serum zinc level
Authors: Weismann K , Høyer H.
Published: July 2023

A significant positive correlation between serum zinc and serum alkaline phosphatase levels was demonstrated in four patients suffering from acrodermatitis enterophathica for which they received oral zinc sulphate therapy. In one of the male patients a significant inverse relation between serum zinc and serum copper was found.
Itraconazole in onychomycosis. Open and double-blind studies.
Authors: Walsøe I , Stangerup M , Svejgaard E
Published: July 2023

Fifteen patients with onychomycosis caused by Trichophyton rubrum or T. mentagrophytes were treated with 50 mg itraconazole daily for 3 to 6 months. Fingernail infections were cured in two patients and two responded with marked improvement, e.g. small residual lesion remained and positive microscopy. The infected toenails were markedly improved in nine of 13 patients. Twenty-seven patients with T. rubrum infected nails were given 100 mg itraconazole daily for 6 to 8 months. Fingernails were cured in nine of eleven patients, while toenail infections were cured in one and markedly improved in 14 of 25 cases. Responses to 100 mg itraconazole versus 500 mg griseofulvin daily for 6 months were compared and evaluated in 20 patients with onychomycosis caused by T. rubrum or T. mentagrophytes. Fingernail infections responded equally well to both drugs with half of the cases cured or markedly improved, whereas toenails responded better to itraconazole, e.g. 4 of 9 were markedly improved versus one of 10 on griseofulvin. In patients given 50 mg itraconazole daily a significantly better response was observed in persons below 30 years of age compared to older individuals. Also, side-effects which were mainly mild and located to the gastro-intestinal tract or the central nervous system were seen less often in this group of patients on the low dose. Follow-up studies showed that cured nails remained cured, that markedly improved toenails continued to improve until cure in three of 21 patients but that aggravation took place through the one year of follow-up in more than half of the patients evaluated as markedly improved at the end of treatment.
Banded structures in multiple familial trichoepithelioma.
Authors: Pfaltz M , Schnyder U W
Published: July 2023

A case of multiple familial trichoepithelioma was studied by electron microscopy. Tumour cells showed a dilated, rough endoplasmic reticulum (rER), in which banded, electron-dense structures measuring approximately 50 nm in width were found. Some of these banded structures were arranged parallel to each other with an interval of 250 nm.
Generalized pustular drug rash induced by hydroxychloroquine.
Authors: Lotem M , Ingber A , Segal R , Sandbank M
Published: July 2023

A 69-year-old man developed a generalized pustular drug rash 2 weeks after starting on hydroxychloroquine sulfate (HCQ) medication. This form of drug eruption had not previously been attributed to HCQ, although a diagnosis of pustular psoriasis cannot be ruled out.
Prognostic significance of digital blood pressure in leg ulcer patients.
Authors: Sindrup J H , Danielsen L , Karlsmark T , Tikjøb G , Jensen B L , Kristensen J K , Avnstorp C , Holstein P
Published: July 2023

In a consecutive series of patients with ulceration of the lower leg referred to the dermatological in-patient department during a 9-month period, a systolic digital blood pressure level (SDBP) below 60 mmHg was used to identify patients with complicating arterial occlusive disease (AOD) of the legs. AOD was diagnosed in 25 patients and stasis ulcers from venous disease (SDBP greater than or equal to 60 mmHg) in 38 patients of the same ages. Patients with ulceration from other causes were excluded. After 1 year, 48% of the patients with AOD and 5% of those with stasis ulcers had died. In the AOD group, 11 legs were amputated. Our figures show that the SDBP is valuable in identifying high-risk patients.
Increased levels of immunoreactive leukotriene B4 in blister fluids of bullous pemphigoid patients and effects of a selective 5-lipoxygenase inhibitor on experimental skin lesions
Authors: Kawana S , Ueno A , Nishiyama S
Published: July 2023

The immunoreactive leukotriene B4 (i-LTB4) and i-LTC4 content in the blister fluids of patients with bullous pemphigoid (BP) was determined by radioimmunoassay. Their amounts significantly exceeded those noted in superficial dermal burn patients and those in the fluids of suction blisters produced on normal human skin. When either BP blister fluids or BP-IgG from the patient sera were injected into guinea pig skin, neutrophil and eosinophil infiltrates were produced in the dermis. In addition, the dermis was noted to undergo marked edematous change. A single oral administration of a selective inhibitor of 5-lipoxygenase 1 hr before the intracutaneous injection of BP-IgG was found to significantly inhibit cell infiltrates. Furthermore, the inhibitor partly suppressed dermal epidermal separation. On the basis of these results. LTB4 and LTC4 appear to be generated in the skin lesions of BP, the former attracting granulocytes to the dermis and the latter, causing exudation.
Preputial ectopic sebaceous glands mimicking molluscum contagiosum.
Authors: Piccinno R , Carrel C F , Menni S , Brancaleon W
Published: July 2023

The authors describe a 12-year-old boy with a peculiar presentation of preputial papular lesions similar to molluscum contagiosum. Histopathologic investigation revealed the presence of a sebaceous gland opening directly onto the surface and hyperplasia of the epithelium.
Changes in renal biopsies during low dosage cyclosporin treatment.
Authors: Zachariae H , Kragballe K , Hansen H E , Olsen T S
Published: July 2023

No abstract available.
Validation of Diagnoses of Atopic Dermatitis in Hospital Registries: A Cross-sectional Database Study from Finland
Authors: Kurki Miika , Sinikumpu Suvi-Päivikki , Kiviniemi Eetu , Jokelainen Jari , Huilaja Laura
Published: July 2023

Abstract is missing (Short communication)
HUBUNGAN ANTARA PENGUASAAN KOSAKATA DAN MOTIVASI BELAJAR DENGAN KETERAMPILAN MENULIS TEKS LAPORAN HASIL OBSERVASI
Authors: I. Zulianti  , S.A. Bowo
Published: July 2023

Keterampilan menulis teks laporan hasil obervasi memiliki urgensi sebagai salah satu keterampilan yang perlu dipelajari karena dapat meningkatkan kemampuan dan kreativitas siswa dalam menuangkan hasil pengamatan ke dalam tulisan ilmiah, baku, dan terstruktur. Penelitian ini bertujuan untuk menjelaskan: (1) hubungan antara penguasaan kosakata dengan keterampilan menulis teks laporan hasil observasi, (2) hubungan antara motivasi belajar dengan keterampilan menulis teks laporan hasil observasi, dan (3) hubungan secara bersama-sama antara penguasaan kosakata dan motivasi belajar dengan keterampilan menulis teks laporan hasil observasi pada siswa kelas VII MTs Negeri 5 Boyolali. Penelitian ini termasuk penelitian kuantitatif (metode penelitian survei). Subjek penelitian yaitu siswa kelas VII MTs Negeri 5 Boyolali tahun ajaran 2022/2023 sebanyak 77 responden yang diambil dari 45% keseluruhan populasi yaitu 170 siswa. Teknik pengumpulan data dalam penelitian ini menggunakan tes dan angket. Teknik analisis data yang digunakan yaitu teknik statistik deskriptif dan teknik analisis inferensial. Setiap instrumen penelitian diuji coba menggunakan uji validitas dan reliabilitas. Hasil penelitian menunjukkan bahwa: (1) terdapat hubungan positif yang signifikan antara penguasaan kosakata dengan keterampilan menulis teks laporan hasil observasi dengan hasil uji signifikan sebesar 8,63, hasil korelasi sebesar 0,32, dan hasil kontribusi sebesar 10,35%, (2) terdapat hubungan positif yang signifikan antara motivasi baca dengan keterampilan menulis puisi dengan hasil uji signifikan sebesar 24,42, hasil korelasi sebesar 0,27, dan hasil kontribusi sebesar 7,29%, dan (3) terdapat hubungan positif yang signifikan antara penguasaan kosa kata dan motivasi baca dengan keterampilan menulis puisi dengan hasil uji signifikan sebesar 7,69 hasil korelasi sebesar 0,41, dan hasil kontribusi sebesar 17,21%.
DEPRESSIVE STATE IN WOMEN REGISTERED PREGNANT
Authors:   Northern State Medical University, Nael–Prupes M. V. , Kharkova O. A. ,   Northern State Medical University, Soloviev A. G. ,   Northern State Medical University
Published: July 2023

It has been determined that the most important factors influencing the occurrence of postpartum depression include a tendency to depressive disorders, especially those which are not diagnosed and/or inadequately treated during pregnancy. This article deals with the prevalence of depression symptoms and the characteristics of depressive state in women registered pregnant. To study the prevalence of depression symptoms and psycho-emotional state questionnaires were used. The WAM questionnaire was used to assess well-being, activity and mood, and the Beck Depression Inventory was used to diagnose depression. The prevalence of depression symptoms in women registered pregnant was 14.9%. Social characteristics did not influence the appearance of symptoms, but living conditions demonstrated such a relationship. Depression risk during pregnancy is three times higher in women who do not have their own housing, but rent it. The indicator of ‘depression’ according to the Beck Depression Inventory was negatively correlated with the indicators of ‘well-being’, ‘mood’ and ‘activity’ (rs= -0.474, р < 0.001, rs= -0.356, р = 0.002, rs = -0.468, р < 0.001). It was also found that the odds ratio of having signs of depression in women registered pregnant is 8.1 times higher when feeling unwell, 7.7 times higher in decreased activity and 17.4 times higher in low mood. The presented characteristics of the depressive state in women registered pregnant have shown that the study of psycho-emotional state in women at different gestation periods can make it possible to notice signs that can lead to postpartum depression and to start a prevention program in time.
THE ILLNESS PERCEPTION IN PATIENTS WITH INFLAMMATORY INTESTINAL DISEASES
Authors:   Moscow Clinical Scientific Center named after A. S. Loginov, Ogarev V. V. ,   Moscow State University of Medicine and Dentistry named after A. I. Yevdokimov, Sirota N. A. ,   Moscow State University of Medicine and Dentistry named after A. I. Yevdokimov, Knyazev O. V. ,   Moscow Clinical Scientific Center named after A. S. Loginov,   Ryzhikh National Medical Research Center for Coloproctology, Polyakova V. V. ,   Moscow Clinical Scientific Center named after A. S. Loginov, Kanatbek kyzy A. ,   Moscow Clinical Scientific Center named after A. S. Loginov,   Moscow State University of Medicine and Dentistry named after A. I. Yevdokimov, Babayan A. F. ,   Moscow Clinical Scientific Center named after A. S. Loginov, Akhmerova P. S. ,   Moscow State University of Medicine and Dentistry named after A. I. Yevdokimov, Bodunova N. A. ,   Moscow Clinical Scientific Center named after A. S. Loginov
Published: July 2023

The course and treatment of various diseases is influenced by such psychological factors as the perception of the illness and self-efficacy in overcoming the disease. Currently, there is an increase in the prevalence of inflammatory bowel disease (IBD) in people of young working age. Along with this, there is a lack of awareness about the perception of patients with IBD of their illness, which in turn may reduce the effectiveness of the treatment provided. The 2021 Clinical Guidelines developed by the Russian Gastroenterological Association mention not only drug treatment, but also psychotherapeutic effects. In this connection, the need to improve the psychological diagnosis and treatment process of patients with IBD is explained. In the course of the study, a comparative analysis of the components of the perception of the illness and self-efficacy in overcoming the disease among patients who perceive their disease as a severe and moderate threat was carried out. The results obtained indicate the need for an integrated approach in accompanying patients with IBD, including both individual psychological counseling and protocols for group psychotherapeutic interventions aimed at correcting the negative perception of the disease, subclinical and clinical levels of anxiety, increasing self-efficacy in relation to overcoming the disease and treatment.
ARTISTS' VIEWS OF PSYCHOLOGICAL WELL-BEING
Authors:   Tyumen State University, Vakarina E. A.
Published: July 2023

The purpose of the study is to identify and describe the sense-groups of artists' views of psychological well-being. Psychological well-being is considered as a multicomponent concept, including cognitive, emotional and behavioral components. 55 artists aged between 19 and 60 took part in the survey. A structured interview about psychological well-being was conducted. Data processing was carried out by means of content analysis. Eight sense-groups related to artists' perceptions of psychological well-being were identified: relationships with others, calm, harmony, mindfulness, satisfaction, mental and physical health and financial well-being. The sense-groups of artists' representations show that the emotional component predominates over the cognitive and behavioral components. However, members of the creative professions find it difficult to manage and regulate their emotional state. Their high sensitivity could be a possible reason. In order to find a foothold in life, they resort to the support of their immediate environment and the establishment of a dialogue with their target audience. Meaningfulness becomes a source of understanding themselves, their thoughts and motives. They become responsible not only for themselves and their lives, but also for the cultural products they create. Presenting their work, where quality prevails over quantity, is part of their self-presentation and self-expression. The study results focus on artists' everyday perceptions of psychological well-being and can be used by psychologists and teachers at secondary and higher education institutions who interact both with students and creative professionals to develop preventive programs aimed at improving the well-being and quality of life of artists.
Exploring Financial Approaches to Evaluate Commercial Bank Profitability: An Empirical Analysis on Capital Adequacy Ratio, Loan Deposit Ratio and Non-Performing Loans
Authors: Soelistyoningrum Jenia Nur , Marcelya Marita , Putri Novinda Krisna
Published: July 2023

Banking is a high-risk industry since it is responsible for managing public assets and investing them in securities or loans. As a result, assessing commercial bank performance is critical for understanding their health and efficiency. A financial approach is used to assess credit risk, liquidity, and bank adequacy in accordance to the requirements of Financial Service Authority (OJK). This research aims to determine the impact of the Capital Adequacy Ratio (CAR), Loan Deposit Ratio (LDR), and Non-Performing Loans (NPL) on bank’s performance in 2017-2019. Using the purposive sampling technique, the final sample consists of 114 observations-sample. A multiple linear regression analysis was adopted on balanced panel data using the secondary data from commercial banking sector in Indonesia Stock Exchange. Chow test and Hausman test were used to finalize the findings which is to ensure that the right model to be used for the analysis. The findings demonstrate that CAR, LDR, and NPL simultaneously impact significantly the performance. However, partially only CAR and NPL show impact on the performance whilst LDR does not. The study provides implications for bank managers in managing capital and loan portfolios. It also contributes to the existing literature on bank performance.
KEWENANGAN RANGKAP JAKSA SEBAGAI PENYIDIK, PENUNTUT UMUM DAN SAKSI PELAPOR (VERBALISAN) TINDAK PIDANA KORUPSI DALAM PERSPEKTIF SISTEM PERADILAN PIDANA TERPADU
Authors: Andreyani Bella , Hidayatullah Hidayatullah , Suyoto Suyoto
Published: July 2023

Penelitian ini bertujuan menjelaskan tentang kewenangan jaksa sebagai penyidik sekaligus sebagai penuntut umum tindak pidana korupsi ditinjau dari asas diferensiasi fungsional dan pengawasan horizontal atas kewenangan rangkap jaksa ditinjau dari sistem peradilan pidana terpadu. Metode yang digunakan dalam penelitian ini adalah yuridis normatif. Dalam teknik pengumpulan data, penulis menggunakan bahan hukum primer, sekunder dan tersier. Setelah diperoleh, maka akan disusun secara sistematis dan selanjutnya dilakukan analisa untuk mendapatkan kejelasan tentang permasalahan yang dikaji.Dari hasil penelitian dan pembahasan dapat dijelaskan bahwa, pertama setelah adanya KUHAP yang menganut asas diferensiasi fungsional maka kewenangan kejaksaan tidak lagi berfungsi sebagai dominus litis. Oleh sebab itu penerapan asas diferensiasi fungsional menempatkan hubungan penyidik dan penuntut umum harus dilihat dari division of power bukan separation of power. Kedua, kewenangan rangkap jaksa dapat terjadi karena dalam hal penataan struktur hukum belum ditempatkan secara proporsional sehingga menimbulkan kerancuan kewenangan dan secara kultur hukum pelaksana sub sistem peradilan pidana cenderung instansi sentris dan menyebabkan egoisme sektoral yang menyebabkan SPPT tidak terlaksana dengan maksimal.
Independent work in the area of distance education: a study of university students' opinions
Authors: Rudina Maryna
Published: July 2023

The article shows the results of a study of university students' opinions about independent work in the area of distance education during martial law in the country. The basis of the study is a questionnaire designed to identify students' opinions and attitudes towards independent work as an individual research form of educational activity. The basis for the research and development of the questionnaire is the scientific and educational principles of the concept "independent work". We have found out that this definition is understood by most scholars as a cognitive activity aimed at self-education and achievement of personally significant goals, is based on independence as a personality trait, and contributes to the formation of self-education skills. However, modern students do not always interpret independent work as an individual research educational activity. The questionnaire focused the respondents' attention on the relevance of independent work and emphasised the importance of this component in distance learning while encouraging students to analyse their own preferences and choose qualities that are important for personal motivation. In addition to the research work, the questionnaire provided an educational goal and self-improvement in terms of understanding the need for independent work as a personal value-oriented activity of the student. To analyse the results, conventional levels were used: high-level choices show an understanding of the relevance and importance of the proposed types of independent work; medium-level choices determine the prospect of strengthening motivation for independent work; low-level choices show the need to develop students' motivation for independent work, to form the need for individual independent work. The analysis of the questionnaire results confirmed the predicted tendency: students more or less understand the essence and importance of independent work and have not thought about this aspect in terms of themselves. Thus, the analysis of students' opinions revealed the need to update distance learning methods in order to stimulate students' motivation to work independently to help them acquire professional competences in the higher education system.