bluuebunny/crossref_metadata_2025 huggingface dataset:
Species Identification of Totoaba (Totoaba macdonaldi) From Swim Bladders by Real‐Time Fluorescence‐Based Recombinase‐Aided Amplification
Authors: Xu Hao , Zhu Songqi , Huang Yun , Deng Yan , Liu Hong , Zheng Xiaocong
Published: September 2024

The increased illegal fishing to supply swim bladders is the current threat to the Totoaba macdonaldi, due to the high commercial value of swim bladders. Species identification is the foundation of the endangered animal protection. Limited by the sophisticated thermal cycling, specialized machine, and sequencing costs, DNA barcoding might not better satisfy the needs of on‐site inspection to the efficiency, convenience, and low cost, although it has reliable results and has been widely used. It is necessary to establish a convenient, rapid, sensitive, and accurate method for customs to inspect the swim bladders in legal or illegal trade on site. In this study, we introduce real‐time fluorescence‐based recombinase‐aided amplification (RF‐RAA) into species identification of swim bladders. Specific primers and probes targeted to Totoaba macdonaldi were designed and the reaction temperature and time were screened. It was applied to the forensic identification of swim bladders confiscated by custom after its sensitivity and specificity were verified. The results showed that (1) the primers of TMcytB F1 and TMcytB R3 targeted to the Cytb had a good amplification at 39°C, 30 cycles (15 min) with good repeatability and stability; (2) the method had good specificity and no cross‐reaction with other 22 swim bladder originated species; (3) the lowest detectable limit (LDL) of this method was 3.7 × 101 copies/μL; (4) about 1.836 kg of all the swim bladders confiscated by Shenzhen customs on 2022 were identified to be Totoaba macdonaldi by using this method. This study provides an effective species identification alternative for competent authorities to tackle the illegal import and market regulation of totoaba swim bladders.
Acute Disseminated Encephalomyelitis Presenting with Neuropsychiatric Symptoms
Authors: Shrestha Mrinal , Joshi Anish , Pandey Ajit , Chaudhary Aashutosh , Shrestha Aman Raj , Koju Naman , Timilsina Sujan , Chaudhary Ashlesha
Published: September 2024

Background. Acute disseminated encephalomyelitis (ADEM) is a rare immune‐mediated pathology involving inflammatory demyelination of the central nervous system. Case Presentation. In this case report, we present the case of a nine‐year‐old female who exhibited altered mental status and focal neurological deficit, subsequently diagnosed as ADEM based on clinical presentation and magnetic resonance imaging (MRI) findings. The patient was managed symptomatically along with glucocorticoids. Conclusion. ADEM must be suspected when a patient, especially a child, presents with prodromal symptoms followed by multifocal neurological symptoms. Diagnosis can be established with an MRI brain scan. Most patients respond to high‐dose intravenous glucocorticoids.
CD24-Targeted NIR-II Fluorescence Imaging Enables Early Detection of Colorectal Neoplasia
Authors: Guo Xiaoyong , Luo Shuangling , Wang Xiaofeng , Cui Yingying , Li Miaomiao , Zhang Zeyu , Fu Lidan , Cao Caiguang , Shi Xiaojing , Liu Haifeng , Qu Yawei , Gao Xiangyu , Hu Zhenhua , Tian Jie
Published: September 2024

Colorectal cancer continues to be a major health issue even though screening methods have facilitated early detection. Despite the high sensitivity of white-light colonoscopy, it frequently overlooks invasive flat or depressed lesions, which can lead to the development of larger, advanced tumors. Fluorescence molecular imaging offers a promising approach for early tumor detection by targeting specific molecular characteristics of lesions. CD24 is upregulated during the adenoma-to-colorectal cancer transition, providing a potential target for fluorescence molecular imaging. In this study, we developed a second near-infrared window (NIR-II) fluorescent probe with a high affinity for CD24 and evaluated its efficacy and targeting ability in cellular models, murine models, and clinical samples of colorectal cancer. CD24 expression was elevated in 76% of adenomas and 80% of colorectal cancers. In a colitis-associated cancer mouse model, NIR-II imaging with the CD24-targeted probe achieved a significantly higher tumor-to-background ratio compared with conventional NIR-I imaging. The probe demonstrated exceptional sensitivity (92%) and specificity (92%) for detecting colorectal cancer, including small lesions less than 1 mm in size. This led to the identification of precancerous lesions missed by white-light detection and lesions missed by NIR-I imaging. Moreover, ex vivo human tissue incubation with the probe supported the potential for intraprocedural lesion identification via topical probe application during colonoscopy. In conclusion, this study successfully demonstrates the potential of CD24-targeted NIR-II imaging for identifying colorectal neoplasia, highlighting its significance for early colorectal cancer detection in the gastrointestinal tract.

Significance: Overexpression of CD24 in colorectal dysplasia provides the opportunity to use an NIR-II fluorescent probe targeting CD24 to detect colorectal neoplasms, including invisible lesions that are missed by white-light colonoscopy.
A B7-H3–Targeted CD28 Bispecific Antibody Enhances the Activity of Anti–PD-1 and CD3 T-cell Engager Immunotherapies
Authors: Moore Gregory L. , Zeng Veronica G. , Diaz Juan E. , Bonzon Christine , Avery Kendra N. , Rashid Rumana , Qi Jing , Nam Dong Hyun , Jacinto Jonathan , Dragovich Matthew A. , Kim Yoon Kyung , Balcazar Karen P. , Bakhit Charles G. , Eivazi Araz , Nguyen Hanh , Muchhal Umesh S. , Szymkowski David E. , Desjarlais John R. , Hedvat Michael
Published: September 2024

T-cell activation is a multistep process requiring T-cell receptor engagement by peptide–MHC complexes (Signal 1) coupled with CD28-mediated costimulation (Signal 2). Tumors typically lack expression of CD28 ligands, so tumor-specific Signal 1 (e.g., neoepitope presentation) without costimulation may be ineffective or even induce T-cell anergy. We designed the bispecific antibody XmAb808 to co-engage the tumor-associated antigen B7-H3 with CD28 to promote T-cell costimulation within the tumor microenvironment. XmAb808 costimulation was measured by its ability to activate and expand T cells and enhance T cell–mediated cancer cell killing in cocultures of human peripheral blood mononuclear cells and cancer cells and in mice engrafted with human peripheral blood mononuclear cells and tumor xenografts. XmAb808 avidly bound cancer cells and stimulated IL2 and IFNγ secretion from T cells cocultured with cancer cells engineered to deliver Signal 1 to T cells via a surface-expressed anti-CD3 antibody. XmAb808 enhanced expression of the antiapoptotic factor Bcl-xL and CD25, promoting survival and IL2-dependent expansion of T cells coupled with increased T cell–mediated cytotoxicity in vitro. XmAb808 combined with an EpCAM×CD3 bispecific antibody to enhance target cell killing through IL2-dependent expansion of CD25+ T cells. This combination also suppressed pancreatic tumor xenograft growth in mice. Furthermore, XmAb808 combined with an anti–programmed cell death protein 1 antibody to suppress breast tumor xenograft growth in mice. XmAb808 as monotherapy and in combination with an anti–programmed cell death protein 1 antibody is currently in clinical development in patients with advanced solid tumors. Our results suggest that XmAb808 may also combine with tumor antigen–targeted anti-CD3 (Signal 1) T-cell engagers.
Table 4 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Efficacy outcomes for the MIBC and mRCC cohorts
Table 3 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Treatment-related adverse events in the MIBC cohort
Table 2 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Treatment-related adverse events in the mRCC cohort
Table 1 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Baseline patient and tumor characteristics by disease cohort
Supplementary Table 2 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

All Adverse Events in the mRCC cohort regardless of attribution
Supplementary Table 1 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Patient Representativeness Table
Supplementary Figure 4 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Flow cytometry of immune cells from serially collected blood samples with evidence of significant decrease in circulating NK cells in: A) Metastatic renal cell carcinoma cohort. B) MIBC cohort.
Supplementary Figure 1 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Consort Diagram for participants in study
Figure 4 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Gene expression analysis comparing immune infiltration in the mRCC treatment-naïve cohort and mRCC cohort from the daratumumab study (prior to treatment) and showing significant reduction across immune cell subtypes in heavily pretreated patients. Tx, treatment.
Figure 3 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

TME evolution of gene expression and IHC before and after treatment with daratumumab. A, mRCC NanoString. B, mRCC IHC. C, MIBC NanoString. D, MIBC IHC. Post, after daratumumab treatment; Pre, before daratumumab treatment; Tx, treatment.
Figure 2 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

IHC for CD38 expression before and after daratumumab treatment in cohorts: A, mRCC. B, MIBC. Post, after daratumumab treatment; Pre, before daratumumab treatment.
Supplementary Figure S4 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: September 2024

A-B, Growth curves of subcutaneous B16F10 (n=3) and orthotopic Py8119 tumors (n=3) implanted into C57BL/6 mice and treated twice weekly IV with 25 m/kg of E7011 until tumors reached roughly 200mm3. Treatment duration was 4 days for B16F10 and 10 days for Py8119. C, Dose response curve of Calu-6 xenografts implanted subcutaneously in nude mice and treated with either control IgG, 1mg/kg, 3mg/kg or 10mg/kg of E7011 IV for 8 days (n=8). D, Representative images of CD31 staining and Hoescht dye staining following treatment. E, Quantitation of Hoescht+ stained area over total area. All quantitation were normalized to the control IgG. Statistics by 2-way ANOVA for growth curves and t-test for perfusion studies; *p<0.05, **p<0.01, ***p<0.001.
Supplementary Figure S3 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: September 2024

A, Schematic of experimental design of Py8119 orthotopically implanted tumors in RiboTagEC mice. Female RiboTagEC mice with 75mg/kg of tamoxifen (20mg/mL) for 5 days by IP injection. Py8119 tumors were implanted at 8 weeks of age and then treated once tumors reached 50mm3 with twice weekly IV control IgG or 6-3-A6 for a total of 10 days (n=3). B, Growth curve of RiboTagEC treated with 25mg/kg of IV control IgG or 6-3-A6 twice weekly for 10 days (n=3). C, Heatmap of endothelial expressed genes segregated by total mRNA input and ribosomal IP mRNA from control IgG treated and 6-3-A6 treated Py8119 tumors. D, PCA plots of the ribosomal IP fraction from control IgG and 6-3-A6 treated tumors. Two samples from the control IgG and 6-3-A6 groups were identified as outliers and removed from analysis. E, Heatmap of downstream Notch regulated genes from endothelial IP of the control IgG or 6-3-A6 treated tumors and quantitative rt-PCR of the canonical Notch target gene Hes1 and Rnd1 amplified from 6-3-A6 treated and control RiboTag IP fractions (n=4). F, Heatmaps of genes associated with significantly enriched or downregulated signaling pathways involved in inflammation and extracellular matrix interactions. All heatmap data presented as Z-scores. Statistics by t-test for qPCR studies
Supplementary Table 1 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

MS data of H1792 cells treated with NMTi
Supplementary Figure S2 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: September 2024

A-C, Weights of Balb/c nude mice implanted with Calu-6, SEKI and DU145 xenografts (n=5 for all tumor models) and treated with control IgG (all), 6-3-A6 (all), bevacizumab (SEKI), lenvatinib (SEKI), or paclitaxel (DU145). D, Mass of non-tumor bearing C57BL/6 mice treated IV with E7011 or control IgG twice weekly for 4 weeks (n=5). E, Representative images of the livers. Insets show 2x magnified view of the vessels at the periphery of the liver lobe. Scale bar = 6cm. F, Final tumor mass of orthotopically implanted Py8119 tumors treated IV with E7011 (25mg/kg) starting 12 hours after initial implantation (n=13 control IgG, n=12 E7011). Growth curve statistics performed with 2-way Anova, plotted as average ± SEM. Statistics by t-test, plotted as average ± SEM; *p<0.05.
Figure S9 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

The PARP inhibitor olaparib rescues death induced by NMTi treatment.
Supplementary Figure S1 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: September 2024

A, Binding curves determined by SPR of 6-3-A6 and E7011 to murine and cynomolgus monkey Notch4. B, Binding of 6-3-A6 and E7011 at increasing concentrations to transfected HEK293 cell lines overexpressing full length human, murine, and cynomolgus Notch4 as assessed by mean fluorescent intensity (MFI) using flow cytometry.
Figure S7 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

Treatment with necroptosis and pyroptosis inhibitors fail to prevent cell death induced by of NMTi treatment in lung carcinoma cells.
Figure S5 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

Inhibition of NMT increases mitochondrial ferrous iron content in (KL/K)MUT but not (KL/K)WT lung carcinoma cells.
Table S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Authors: Poliaková Turan Michaela , Riedo Rahel , Medo Matúš , Pozzato Chiara , Friese-Hamim Manja , Koch Jonas P. , Coggins Si’Ana A. , Li Qun , Kim Baek , Albers Joachim , Aebersold Daniel M. , Zamboni Nicola , Zimmer Yitzhak , Medová Michaela
Published: September 2024

Basic statistics of the downloaded TCGA data.
Figure S4 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

Inhibition of NMT increases mitochondrial ferrous iron content in (KL/K)MUT but not (KL/K)WT lung carcinoma cells.
Table S2 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Authors: Poliaková Turan Michaela , Riedo Rahel , Medo Matúš , Pozzato Chiara , Friese-Hamim Manja , Koch Jonas P. , Coggins Si’Ana A. , Li Qun , Kim Baek , Albers Joachim , Aebersold Daniel M. , Zamboni Nicola , Zimmer Yitzhak , Medová Michaela
Published: September 2024

Differential expression analysis of the GTL-16 and EBC-1 transcriptomics data.
Figure S3 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

Inhibition of NMT alters iron homeostasis in (KL/K)MUT lung carcinoma cells.
Table S1 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Authors: Poliaková Turan Michaela , Riedo Rahel , Medo Matúš , Pozzato Chiara , Friese-Hamim Manja , Koch Jonas P. , Coggins Si’Ana A. , Li Qun , Kim Baek , Albers Joachim , Aebersold Daniel M. , Zamboni Nicola , Zimmer Yitzhak , Medová Michaela
Published: September 2024

Differential abundance analysis and ion annotation matches for non-targeted metabolomics measurements.
Figure S6 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Authors: Poliaková Turan Michaela , Riedo Rahel , Medo Matúš , Pozzato Chiara , Friese-Hamim Manja , Koch Jonas P. , Coggins Si’Ana A. , Li Qun , Kim Baek , Albers Joachim , Aebersold Daniel M. , Zamboni Nicola , Zimmer Yitzhak , Medová Michaela
Published: September 2024

GART protein expression upon MAPK and PI3K targeting: GART protein levels in untreated GTL-16 and EBC-1 cells and after MAPK (AZD6244) and PI3K (LY294002) pathways inhibition. ß Actin was used as a loading control.
Figure S2 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

Genetic targeting of NMT1 decreases the viability of (KL/K)MUT lung carcinoma.
Figure S5 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Authors: Poliaková Turan Michaela , Riedo Rahel , Medo Matúš , Pozzato Chiara , Friese-Hamim Manja , Koch Jonas P. , Coggins Si’Ana A. , Li Qun , Kim Baek , Albers Joachim , Aebersold Daniel M. , Zamboni Nicola , Zimmer Yitzhak , Medová Michaela
Published: September 2024

GART and E2F1 mRNA levels following METi combined with IR: mRNA levels of GART (left) and E2F1 (right) following METi (50nM, 24 hr), IR (10 Gy, 1 hr) and their combination in GTL-16 and EBC-1 cells.
Figure S4 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Authors: Poliaková Turan Michaela , Riedo Rahel , Medo Matúš , Pozzato Chiara , Friese-Hamim Manja , Koch Jonas P. , Coggins Si’Ana A. , Li Qun , Kim Baek , Albers Joachim , Aebersold Daniel M. , Zamboni Nicola , Zimmer Yitzhak , Medová Michaela
Published: September 2024

Supplementations with nucleosides and hypoxanthine: (A) Proliferation of GTL-16 and EBC-1 cells upon supplementation with nucleosides or hypoxanthine. (B) Apoptosis (caspase-3 activation) in GTL-16 and EBC-1 upon supplementation with nucleosides, hypoxanthine or their combination.
Figure S3 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Authors: Poliaková Turan Michaela , Riedo Rahel , Medo Matúš , Pozzato Chiara , Friese-Hamim Manja , Koch Jonas P. , Coggins Si’Ana A. , Li Qun , Kim Baek , Albers Joachim , Aebersold Daniel M. , Zamboni Nicola , Zimmer Yitzhak , Medová Michaela
Published: September 2024

Supplementations with glutamine, serine, and folic acid: (A) Proliferation of GTL-16 and EBC-1 cells upon supplementation with glutamine, serine or folic acid. (B) Apoptosis (caspase-3 activation) in GTL-16 and EBC-1 cells upon supplementation with glutamine, serine or folic acid.
Figure S10 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

Mitochondria is a key target of NMT inhibitors.
Figure S2 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Authors: Poliaková Turan Michaela , Riedo Rahel , Medo Matúš , Pozzato Chiara , Friese-Hamim Manja , Koch Jonas P. , Coggins Si’Ana A. , Li Qun , Kim Baek , Albers Joachim , Aebersold Daniel M. , Zamboni Nicola , Zimmer Yitzhak , Medová Michaela
Published: September 2024

Suppementary metabolomics data: (A) Heat map determining top hits of metabolite ions in all cell lines at 24 hrs time-point post METi (|log2FC| > 0.5; adj.P value < 0.01). (B) Differences in metabolite ions (dots) abundance in METi-treated (24 hrs) and control cells. Statistically significant differences (|log2FC| > 0.5; P value < 0.01) are highlighted dark blue. (C) Enrichment analysis of the metabolomics data for GTL-16 and EBC-1 cells after 50 nM METi for 24 hrs, focusing on purine-related pathways.
Figure S1 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network
Authors: Poliaková Turan Michaela , Riedo Rahel , Medo Matúš , Pozzato Chiara , Friese-Hamim Manja , Koch Jonas P. , Coggins Si’Ana A. , Li Qun , Kim Baek , Albers Joachim , Aebersold Daniel M. , Zamboni Nicola , Zimmer Yitzhak , Medová Michaela
Published: September 2024

p4E-BP1 protein levels upon MET inhibition: Whole-cell lysates were subjected to Western blotting using a specific antibody against p4E-BP1 following the treatment either with vehicle or 50nM tepotinib (EMD1214063, shortly EMD) for either 4 or 24h as indicated. Western blots representative of N=3 independent experiments are shown.
Table S4 from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma
Authors: Iwanaga Ritsuko , Yamamoto Tomomi M. , Gomez Karina , Nguyen Lily L. , Woodruff Elizabeth R. , Post Miriam D. , Mikeska Railey G. , Danis Etienne , Danhorn Thomas , Boorgula Meher P. , Mitra Siddhartha S. , Marjon Nicole A. , Bitler Benjamin G. , Brubaker Lindsay W.
Published: September 2024

TIMERv2
Table S3 from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma
Authors: Iwanaga Ritsuko , Yamamoto Tomomi M. , Gomez Karina , Nguyen Lily L. , Woodruff Elizabeth R. , Post Miriam D. , Mikeska Railey G. , Danis Etienne , Danhorn Thomas , Boorgula Meher P. , Mitra Siddhartha S. , Marjon Nicole A. , Bitler Benjamin G. , Brubaker Lindsay W.
Published: September 2024

Nanostring
Table S2 from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma
Authors: Iwanaga Ritsuko , Yamamoto Tomomi M. , Gomez Karina , Nguyen Lily L. , Woodruff Elizabeth R. , Post Miriam D. , Mikeska Railey G. , Danis Etienne , Danhorn Thomas , Boorgula Meher P. , Mitra Siddhartha S. , Marjon Nicole A. , Bitler Benjamin G. , Brubaker Lindsay W.
Published: September 2024

Primers
Supplementary Table 6 from Spatial Landscape of Malignant Pleural and Peritoneal Mesothelioma Tumor Immune Microenvironments
Authors: Ma Xiaojun , Lembersky David , Kim Elena S. , Becich Michael J. , Testa Joseph R. , Bruno Tullia C. , Osmanbeyoglu Hatice U.
Published: September 2024

The association of immune cells and cellular neighborhood proportion with overall survival in all malignant mesothelioma (MM) as well as for malignant pleural mesothelioma (MPM) and malignant peritoneal mesothelioma (MPeM) separately.
Supplementary Table 5 from Spatial Landscape of Malignant Pleural and Peritoneal Mesothelioma Tumor Immune Microenvironments
Authors: Ma Xiaojun , Lembersky David , Kim Elena S. , Becich Michael J. , Testa Joseph R. , Bruno Tullia C. , Osmanbeyoglu Hatice U.
Published: September 2024

Comparison of cell type distributions between malignant pleural mesothelioma (MPM) and malignant peritoneal mesothelioma (MPeM) within the same histologic subtypes.
Figure S5 from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma
Authors: Iwanaga Ritsuko , Yamamoto Tomomi M. , Gomez Karina , Nguyen Lily L. , Woodruff Elizabeth R. , Post Miriam D. , Mikeska Railey G. , Danis Etienne , Danhorn Thomas , Boorgula Meher P. , Mitra Siddhartha S. , Marjon Nicole A. , Bitler Benjamin G. , Brubaker Lindsay W.
Published: September 2024

In vivo modeling with loss of CBX2 expression and Nanostring pathway analysis
Figure S4 from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma
Authors: Iwanaga Ritsuko , Yamamoto Tomomi M. , Gomez Karina , Nguyen Lily L. , Woodruff Elizabeth R. , Post Miriam D. , Mikeska Railey G. , Danis Etienne , Danhorn Thomas , Boorgula Meher P. , Mitra Siddhartha S. , Marjon Nicole A. , Bitler Benjamin G. , Brubaker Lindsay W.
Published: September 2024

M1/M2 macrophages convey differential survival outcomes. M1/M2 gating strategy. CD68 gating of monocytes in culture system.
Supplementary Table 1 from Spatial Landscape of Malignant Pleural and Peritoneal Mesothelioma Tumor Immune Microenvironments
Authors: Ma Xiaojun , Lembersky David , Kim Elena S. , Becich Michael J. , Testa Joseph R. , Bruno Tullia C. , Osmanbeyoglu Hatice U.
Published: September 2024

Dataset characteristics
Figure S3 from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma
Authors: Iwanaga Ritsuko , Yamamoto Tomomi M. , Gomez Karina , Nguyen Lily L. , Woodruff Elizabeth R. , Post Miriam D. , Mikeska Railey G. , Danis Etienne , Danhorn Thomas , Boorgula Meher P. , Mitra Siddhartha S. , Marjon Nicole A. , Bitler Benjamin G. , Brubaker Lindsay W.
Published: September 2024

Modulation of CBX2 enhances monocyte infiltration
Supplementary Figure 1 from Spatial Landscape of Malignant Pleural and Peritoneal Mesothelioma Tumor Immune Microenvironments
Authors: Ma Xiaojun , Lembersky David , Kim Elena S. , Becich Michael J. , Testa Joseph R. , Bruno Tullia C. , Osmanbeyoglu Hatice U.
Published: September 2024

Example of 7-plex healthy donor lymphoid tissue as a control and for validation. All channels combined as well as Individual marker channels (pCK: pan-cytokeratin).
Supplementary Figure 2 from IFNγ Production by Functionally Reprogrammed Tregs Promotes Antitumor Efficacy of OX40/CD137 Bispecific Agonist Therapy
Authors: Imianowski Charlotte J. , Kuo Paula , Whiteside Sarah K. , von Linde Teresa , Wesolowski Alexander J. , Conti Alberto G. , Evans Alexander C. , Baird Tarrion , Morris Benjamin I. , Fletcher Nicole E. , Yang Jie , Poon Edmund , Lakins Matthew A. , Yamamoto Masahiro , Brewis Neil , Morrow Michelle , Roychoudhuri Rahul
Published: September 2024

Supplementary Figure 2: T cell populations in the spleen and tumor of FS120m treated mice. (A) Percentages of indicated T cell populations in the tumors of mice treated with FS120m or control antibodies. (B) Percentages of indicated T cell populations in the spleens of mice treated with FS120m or control antibodies. (C) Absolute counts of exTreg cells and Foxp3+ RFP+ Treg cells per gram of tumors (left) and in whole spleens (right) of FS120m treated animals. (D) Absolute counts of IFN-γ producing exTreg cells and Foxp3+ RFP+ Treg cells per gram of tumors (left) and in whole spleens (right) of FS120m-treated animals. (E) Absolute counts of TNF producing exTreg cells and Foxp3+ RFP+ Treg cells per gram of tumors (left) and in whole spleens (right) of FS120m-treated animals. * P ≤ 0.05, ** P ≤ 0.01. Student’s t test. Bars and error are mean and s.e.m.
The London Regime’s Adaptability and Impact
Authors: Pacheco Castillo José M , Seybold Dorothee , Santillo David
Published: September 2024

The London Convention (LC), adopted in 1972, and its successor, the London Protocol (LP) of 1996, constitute key regulatory frameworks working in parallel, aimed at mitigating waste dumping at sea and safeguarding the marine environment. These treaties, which share the objective of controlling marine pollution, have also evolved to address emerging environmental issues such as marine geoengineering and carbon capture and storage within the context of the current triple planetary crisis. As the LC/LP regime marked its fiftieth anniversary in 2022, both achievements and ongoing challenges in combating pollution from dumping activities were acknowledged, emphasising the need for continual adaptation to protect the marine environment effectively. This article examines the adaptability and impact of the LC/LP regime over the past five decades, identifying strengths and proposing future steps to ensure the preservation of ocean health for future generations.
Special Issue on Protecting the Ocean: The London Convention and Stockholm Declaration at Fifty – Introduction
Authors: Derrig Ríán , Long Ronán , Sun Zhen , Stöfen-O’Brien Aleke
Published: September 2024

The introduction to this special issue of nineteen short articles, a result of a conference hosted at the World Maritime University (WMU) in October 2022 to mark the fiftieth anniversary of the adoption of the Stockholm Declaration and London Convention. The conference was co-organised by the WMU-Sasakawa Global Ocean Institute and the International Maritime Organization (IMO) under the title ‘Protecting the Ocean – Moving Forward at 50: London Convention and Stockholm Declaration’. The articles in this special issue contextualise these instruments and practice across international environmental law, the law of the sea, and maritime law that descends from them (Part 1); interrogate their allocation of liability and responsibility for protecting the marine environment (Part 2); consider their incorporation of plural sources of knowledge (Part 3); and highlight their instantiation of, and potential to change, relations of international political economy (Part 4).
Rice Cultivation and the Struggle for Subsistence in Early Colonial Suriname (1668–1702)
Authors: Elfrink Thijs L. , van de Hoef Marden J.J. , van Montfort Jip , Bruins Anna L. , van Andel Tinde
Published: September 2024

The Black Rice Debate discusses the agency of enslaved Africans in rice cultivation in the Americas from the seventeenth century onward. With regard to Suriname, it was considered highly unlikely that rice grew there before 1730 and that Africans at that time knew how to grow rice. This contradicts Maroon oral history, which dates circa 1690 as the time that their first ancestors escaped into the interior forests with rice. Based on Dutch archival records, we show that rice was present in Suriname before the Dutch conquered the colony in 1668. Shortly afterward, it became a staple food as a means to mitigate the ongoing food scarcity. Enslaved Africans played a crucial role in the establishment of designated plantations to grow subsistence crops. Archival records also indicate that conditions were present as early as 1686 for enslaved Africans to escape slavery, bringing rice with them. Our research highlights the importance of connecting archival data to geographical, botanical, and oral history research to reveal misrepresented historical actors, such as enslaved Africans.
A new species of Craterium (Myxomycetes, Physarales, Physaraceae) with a mottled peridium
Authors: GMOSHINSKIY VLADIMIR I. , PRIKHODKO ILYA S. , NOVOZHILOV YURI K.
Published: September 2024

A new species of Craterium, described herein as С. guttatum, was recovered in Russia, during intensive field work in the Kaluzhskiye Zaseki Nature Reserve (Kaluga Oblast’) and in the Sudogodskiy District of the Vladimir Oblast’. Morphological details of sporocarps and spores were examined by light and scanning electron microscopy. The new species is characterized by a unique combination of morphological characters, such as a beaker-shaped sporotheca with a mottled peridium and a prominent line of dehiscence separating the upper part of the sporotheca in the form of a convex white lid, as well as spores densely ornamented with small warts grouped in clusters. The partial sequences of the 18S rRNA, EF1α and mtSSU genes of C. guttatum differ significantly from all Craterium species sequences available to date.
TWO NEW SPECIES OF PAYPAYROLA (VIOLACEAE) FROM THE CAMPINARANAS OF THE BRAZILIAN AMAZON
Authors: OLIVEIRA JOSÉ FLORENCIO CERQUEIRA , SANTOS FELIPE DA SILVA , MOREIRA ARIANE DOS SANTOS , QUEIROZ LUCIANO PAGANUCCI DE
Published: September 2024

Paypayrola is a small genus of Violaceae consisting of small trees or shrubs found in the humid forests of South America. The boundaries between species have proven problematic, particularly among taxa in the Amazon. Through the analysis of Paypayrola specimens from this region, we have identified two new species, potentially restricted to campinarana vegetation. Paypayrola oppositifolia and P. pubiflora are distinguished from other known species in the genus by their phyllotaxy and the indumentum of reproductive parts. We provide morphological descriptions, illustrations, distribution maps, conservation status of the new species, and compare them with Amazonian species that are morphologically similar.
A new species of Aspalathus (Fabaceae, Crotalarieae) from the Cape Floristic Region, South Africa
Authors: STIRTON CHARLES H. , PREEZ BRIAN DU , HELME NICK , MUASYA MUTHAMA
Published: September 2024

A new species from the Western Cape, South Africa is described: Aspalathus praetermissa—a highly localized and critically endangered endemic, occurring between Elandsbaai, Redelinghuys, and Paleisheuwel. This species is morphologically similar to A. quinquefolia subsp. virgata, but differs in having small, 5.5–6.0 mm long, pale yellow flowers (versus flowers 7–10 mm long, bright yellow); more extensive pubescence on wing petals as well as keel petals, blade not flaring apically (versus wing petals partially pubescent to glabrous, flaring apically). A composite plate and map for A. praetermissa are presented, and a taxonomic key to the A. quinquefolia complex.
A new species of Brongniartia (Fabaceae: Faboideae) from southwestern Oaxaca, México
Authors: DORADO ÓSCAR , FLORENTINO ALEXIS
Published: September 2024

A new species of Brongniartia is described from southwestern Oaxaca in México, where it occurs in Seasonally Dry Tropical Forests and Woodlands. Brongniartia dulce is discussed in relation to other members of the genus and their morphological characters, particularly the shape and size of the stipules and bracteoles.
Coupled Fire–Atmosphere Simulations of the Split, Croatia, Wildfire
Authors: Tomašević Ivana Čavlina , Malečić Barbara , Vučetić Višnjica , Prtenjak Maja Telišman , Cheung Kevin K. W. , Fox-Hughes Paul , Beggs Paul J.
Published: September 2024

The Weather Research and Forecasting Spread FIRE (WRF-SFIRE) model was used to simulate the evolution of the fire perimeter for the Split wildfire in Croatia, evaluated in our previous detailed reconstruction of the event. A four-domain configuration was applied, with the innermost domain having a resolution of 500 m with a planetary boundary layer parameterization. The coupled fire grid was further downscaled to 33.3-m resolution, using the best available estimates of topography and fuel load data. WRF-SFIRE simulated slightly smaller fire areas in the four observed fire perimeter stages of the Split wildfire event, especially the northwestward spread in the last stage along the Adriatic coast. Additional experiments with multiple ignitions in the WRF-SFIRE model, representing the spotting mechanism, successfully simulated the northwestward spread in the event. The study also included sensitivity experiments that turned off the heat and moisture flux coupling between WRF and the fire grid. It was found that the simulated fire area is larger than the model run that included heat and moisture feedback from the fire grid to the atmosphere, which is contrary to some previous studies. The large wind speed and convergence along the fire line in our feedback-on simulation, which constrain the fire when there are feedback processes, were likely the cause of the smaller fire area. Last, areas of pine that burnt in the Split fire event favored crown fire spread, which is not represented in the current modeling framework of WRF-SFIRE.
Diurnal Off-Mountain Propagation of Rainfall and Low-Level Vertical Velocity over the Lee Side of the Yungui Plateau
Authors: Hu Xuelin , Li Jian , Chen Haoming , Yu Rucong
Published: September 2024

Diurnal off-mountain propagation is a distinctive feature of rainfall over terrestrial areas, whereas the causes of this phenomenon are not well understood. Focused on the rainfall downstream of the Yungui Plateau (YGP), this study aims to examine whether the gravity waves stimulated by an assumed terrain-related thermal forcing could explain the feature. The results show that the rainfall diurnal phase propagates eastward at a speed of approximately 13 m s−1 over the lee side of YGP during warm seasons. The diurnal amplitude reaches its zonally maximum over the slope of the YGP and drops sharply downstream the terrain. The low-level vertical velocity exhibits similar diurnal characteristics. A linear model forced by a hollow heating is proposed to mimic the thermal forcing related to a mountain. Experiments with the model show that there are mainly two branches of waves around the terrain. One is over the upstream with upwind-tilting phase lines that move toward −z and −x directions. The other branch exists over the lee side of terrain with downwind-tilting phase lines that move toward −z and +x directions, which is considered to be relevant to the off-mountain propagation feature. The wave behavior over the YGP is then reproduced using the model. It is shown that the main features of the diurnal phase lag and the zonal amplitude distribution pattern of the low-level updraft could be captured by the model, suggesting an important role of the gravity wave in driving the diurnal propagation of vertical velocity and rainfall downstream large terrains.

Significance Statement

The purpose of this study is to better understand why diurnal off-mountain rainfall propagation exists over the downstream of Yungui Plateau (YGP). This is important because the off-mountain rainfall propagation influences the rainfall events over the lee side of mountains and can further influence people’s lives therein. Inspired by previous studies on coastal rainfall, we proposed a simplified linear gravity wave model forced by a topography-related heating function. The results showed that the thermally forced gravity waves could reproduce the main features of the propagating phase and amplitude pattern of upward motion disturbance over the lee side of the YGP. Our results highlight the importance of gravity waves stimulated by topography-related heating on the diurnal propagation features over the downstream of mountains.