bluuebunny/crossref_metadata_2025 huggingface dataset:
Does the Pathologic Fracture Predict Severe Paralysis in Patients with Metastatic Epidural Spinal Cord Compression (MESCC)?—A Retrospective, Single-Center Cohort Analysis
Authors: Klein Lukas , Herget Georg W. , Ihorst Gabriele , Lang Gernot , Schmal Hagen , Hubbe Ulrich
Published: February 2023

Currently, there is uncertainty about the predictive factors for metastatic epidural spinal cord compression (MESCC) and consecutive symptomatology in tumor patients. Prognostic algorithms for identifying patients at risk for paralysis are missing. The influence of the pathologic fracture on the patient’s symptoms is widely discussed in the literature and we hypothesize that pathologic fractures contribute to spinal cord compression and are therefore predictive of severe paralysis. We tested this hypothesis in 136 patients who underwent surgery for spinal metastases. The most common primary cancers were prostate (24.3%, n = 33), breast (11.0%, n = 15), lung (10.3%, n = 14), and cancer of unknown primary (10.3%, n = 14). MESCC primarily affected the thoracic (77.2%, n = 105), followed by the lumbar (13.2%, n = 18) and cervical (9.6%, n = 13) spine. Pathologic fractures occurred in 63.2% (n = 86) of patients, mainly in osteolytic metastases. On the American spinal injury association (ASIA) impairment scale (AIS), 63.2% (n = 86) of patients exhibited AIS grade D and 36.8% (n = 50) AIS grade C-A preoperatively. The presence of a pathologic fracture alone did not predict severe paralysis (AIS C-A, p = 0.583). However, the duration of sensorimotor impairments, patient age, spinal instability neoplastic score (SINS), and the epidural spinal cord compression (ESCC) grade together predicted severe paralysis (p = 0.006) as did the ESCC grade 3 alone (p = 0.028). This is in contrast to previous studies that stated no correlation between the degree of spinal cord compression and the severity of neurologic impairments. Furthermore, the high percentage of pathologic fractures found in this study is above previously reported incidences. The risk factors identified can help to predict the development of paralysis and assist in the improvement of follow-up algorithms and the timing of therapeutic interventions.
One-Stage Immediate Alloplastic Breast Reconstruction in Large and Ptotic Breasts: An Institutional Algorithm
Authors: Rampazzo Silvia , Spissu Noemi , Pinna Michela , Sini Germana A. M. , Trignano Emilio , Nonnis Rita , Sanna Claudia , Rodio Manuela , Tettamanzi Matilde , Rubino Corrado
Published: February 2023

Immediate implant-based breast reconstruction in patients with large and ptotic breasts may be challenging due to skin redundancy. The use of a reduction mammoplasty pattern for the mastectomy skin excision has proven to be a reliable option for these patients as it allows for a better shape, projection, and symmetrization. This approach has been described in the literature for both one- and two-stage reconstruction with either sub- or pre-pectoral reconstruction with an acellular dermal matrix (ADM) or non-biological mesh. One-stage immediate breast reconstructions have a positive significant impact on patients’ psychosocial well-being and quality of life. The purpose of this paper is to describe an institutional algorithm that allows one to perform one-stage implant-based breast reconstructions in patients with large and ptotic breasts.
Influence of Alternating Current Density on the Mechanical Behavior and Microstructure of PEO-Coated 7075 Aluminum Alloy
Authors: Erdenebat Tumur Ochir , Telmenbayar Lkhagvaa , Yang Daejeong , Song Minjung , Ramu Adam Gopal , Choi Dongjin
Published: February 2023

The objective of the study was to investigate the characteristics of coatings formed on 7075 Al alloy using a plasma electrolytic oxidation (PEO) method in silicate electrolytes under alternating current conditions. The properties of the coatings were evaluated based on the current density applied during the experimental process. To analyze the samples, the surface and cross-sectional images of the coatings were observed using scanning electron microscopy. The results showed that the PEO coatings were between 25–102 µm in thickness, and the thickness was found to be dependent on the applied current density. The hardness values of the PEO coatings were found to be significantly, approximately three times, higher than the uncoated alloy. Wear analysis revealed that the PEO coatings formed under current densities of 8.8 A/dm2 and 17.8 A/dm2 exhibited the best wear resistance among all the coatings. In addition, the PEO coatings also displayed good corrosion resistance, with the resistance of the coatings formed under the current densities of 13.5 A/dm2 and 17.8 A/dm2 being significantly improved compared to that of the bare Al alloy. The most effective anticorrosion PEO coating was found to be the one formed under a current density of 17.8 A/dm2. The wear depths of the PEO coatings formed under current densities of 8.8 A/dm2 and 17.8 A/dm2 were low, resulting in high wear resistance. Among all the PEO coatings, the coating formed under a current density of 17.8 A/dm2 showed the best overall anticorrosion and mechanical properties. Overall, the study highlights the potential of PEO coatings in significantly improving the corrosion and wear resistance of 7075 Al alloy. The results of the study provide useful information for the selection of current density for the PEO coating process on 7075 Al alloy to achieve desired properties.
Synthesis of Chitosan Capped Zinc Sulphide Nanoparticle Composites as an Antibacterial Agent for Liquid Handwash Disinfectant Applications
Authors: Kusrini Eny , Wilson Lee D. , Padmosoedarso Kanya Maharani , Mawarni Dias Puspitaning , Sufyan Muhammad , Usman Anwar
Published: February 2023

There is a need to develop alternative disinfectants that differ from conventional antibiotics to address antibacterial resistance, along with specialized materials for biomedical applications. Herein, we report on the synthesis of zinc sulfide (ZnS) capped with chitosan (CS) to produce CS-ZnS nanocomposites (NCs), which were assayed for antibacterial activity in liquid handwash formulations. The CS-ZnS NCs were prepared using the bottom-up wet-chemical method. The role of CS as the capping agent was investigated by varying the ratio of CS with respect to the ZnS precursor. The prepared CS-ZnS NCs were characterized using complementary spectral methods: scanning electron microscopy–energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. The antibacterial activities of liquid handwash (LH) formulations containing 1% (w/w) CS-ZnS NCs were tested against Staphylococcus aureus and Escherichia coli using the agar diffusion test method. This LH formulation displayed antibacterial activity against S. aureus with an average inhibition zone diameter in the range of 16.9–19.1 mm, and met the quality standards set by the National Standardization Agency. The formulated LH solutions containing CS-ZnS NCs showed antibacterial activity, which suggests that the CS-ZnS NCs have potential as an alternative active ingredient for tailored and non-irritant antibacterial LH detergents.
Age Assessment through Root Lengths of Mandibular Second and Third Permanent Molars Using Machine Learning and Artificial Neural Networks
Authors: Patil Vathsala , Saxena Janhavi , Vineetha Ravindranath , Paul Rahul , Shetty Dasharathraj K. , Sharma Sonali , Smriti Komal , Singhal Deepak Kumar , Naik Nithesh
Published: February 2023

The present study explores the efficacy of Machine Learning and Artificial Neural Networks in age assessment using the root length of the second and third molar teeth. A dataset of 1000 panoramic radiographs with intact second and third molars ranging from 12 to 25 years was archived. The length of the mesial and distal roots was measured using ImageJ software. The dataset was classified in three ways based on the age distribution: 2–Class, 3–Class, and 5–Class. We used Support Vector Machine (SVM), Random Forest (RF), and Logistic Regression models to train, test, and analyze the root length measurements. The mesial root of the third molar on the right side was a good predictor of age. The SVM showed the highest accuracy of 86.4% for 2–class, 66% for 3–class, and 42.8% for 5–Class. The RF showed the highest accuracy of 47.6% for 5–Class. Overall the present study demonstrated that the Deep Learning model (fully connected model) performed better than the Machine Learning models, and the mesial root length of the right third molar was a good predictor of age. Additionally, a combination of different root lengths could be informative while building a Machine Learning model.
Mechanical Performance over Energy Expenditure in MEX 3D Printing of Polycarbonate: A Multiparametric Optimization with the Aid of Robust Experimental Design
Authors: Vidakis Nectarios , Petousis Markos , David Constantine N. , Sagris Dimitrios , Mountakis Nikolaos , Karapidakis Emmanuel
Published: February 2023

Sustainability and energy efficiency of additive manufacturing (AM) is an up-to-date industrial request. Likewise, the claim for 3D-printed parts with capable mechanical strength remains robust, especially for polymers that are considered high-performance ones, such as polycarbonates in material extrusion (MEX). This paper explains the impact of seven generic control parameters (raster deposition angle; orientation angle; layer thickness; infill density; nozzle temperature; bed temperature; and printing speed) on the energy consumption and compressive performance of PC in MEX AM. To meet this goal, a three-level L27 Taguchi experimental design was exploited. Each experimental run included five replicas (compressive specimens after the ASTM D695-02a standard), summating 135 experiments. The printing time and the power consumption were stopwatch-derived, whereas the compressive metrics were obtained by compressive tests. Layer thickness and infill density were ranked the first and second most significant factors in energy consumption. Additionally, the infill density and the orientation angle were proved as the most influential factors on the compressive strength. Lastly, quadratic regression model (QRM) equations for each response metric versus the seven control parameters were determined and evaluated. Hereby, the optimum compromise between energy efficiency and compressive strength is attainable, a tool holding excessive scientific and engineering worth.
Factors Affecting Earthwork Volume in Forest Road Construction on Steep Terrain
Authors: Papa Ivica , Picchio Rodolfo , Lovrinčević Mihael , Janeš David , Pentek Tibor , Validžić Dino , Venanzi Rachele , Đuka Andreja
Published: February 2023

Forest roads, as a prerequisite for high-quality forest management, should be optimally distributed in order to avoid negative environmental impacts and to best fulfill their task. In the design phase of forest roads, it is necessary to know which factors influence most the volume of earthworks to enable the designer to best adapt to the terrain requirements. In this paper the impact of an average cross terrain slope and carriageway value of a forest road on cut and fill volume is analyzed. The research was carried out in the area of the management unit Trovrh–Kik, characterized by irregular terrain with slopes ranging between 27 and 58%, and on some micro locations even up to 84%. On eight forest roads, based on standard cross-section profiles, the influence of the average cross terrain slope and carriageway value (difference between ground level and grade level) of the forest road on the cut and fill volume per 1 m of the forest road route was analyzed. The obtained coefficients of determination indicate a strong correlation between the cut volume and carriageway value (R2 = 0.6841), and a moderate correlation between the fill volume and carriageway value (R2 = 0.5619). Unlike the influence of carriageway value on the cut and fill volume, the correlation between the cross terrain slope and fill volume is weak (R2 = 0.2076) or moderate in the case of the cut volume (R2 = 0.3167). On the basis of the analyzed standard cross-section profiles, it was determined that the carriageway value was 0.051 m, where the difference between the cut and fill volume was minimum and the average actual carriageway value was determined to be −0.09 m. It can be concluded that, on terrains with large and varying slopes, there is no unique model or terrain factor that could describe the earthworks required in the construction of a forest road. However, it is beyond doubt that the increase in the carriageway value and cross terrain slope caused the increase in the aforementioned volumes.
Person Agreement with Anaphors: Evidence from Tatar
Authors: Lyutikova Ekaterina
Published: February 2023

In this paper, I present evidence for variable agreement with anaphors in Tatar. I show that inflected reflexives trigger co-varying person agreement as DP/nominalization subjects and as complements of postpositions, which appears to contradict the generalization on the anaphor agreement effect (AAE). At the same time, inflected reciprocals induce 3p agreement on external targets. These data are puzzling in two aspects. First, it is unclear how to derive co-varying agreement with inflected reflexives because it cannot be handled as a regular exception to AAE predicted to arise by the agreement-based theory if the antecedent of the anaphor is positioned lower than the agreement target. Secondly, the difference between reflexives and reciprocals with respect to external agreement looks enigmatic. I propose that Tatar reflexives and reciprocals, despite their superficial resemblance, have different internal structures, which in turn bring about differences in their feature sets, and external agreement reveals these differences. As to AAE violations, I propose that the Tatar data can be accounted for under the feature sharing approach whereby the features on the anaphor and on the external probe are first identified as instances of the same feature set and then valued by the anaphor’s binder.
Brodifacoum Levels and Biomarkers in Coastal Fish Species following a Rodent Eradication in an Italian Marine Protected Area: Preliminary Results
Authors: Caliani Ilaria , Di Noi Agata , Amico Carlo , Berni Roberto , Romi Marco , Cai Giampiero , Guarnieri Massimo , Navone Augusto , Spano Giovanna , Howald Gregg R. , Sposimo Paolo , Marsili Letizia
Published: February 2023

Brodifacoum is the most common rodenticide used for the eradication of invasive rodents from islands. It blocks the vitamin K cycle, resulting in hemorrhages in target mammals. Non-target species may be incidentally exposed to brodifacoum, including marine species. A case study conducted on the Italian Marine Protected Area of Tavolara Island was reported after a rodent eradication using the aerial broadcast of a brodifacoum pellet. Brodifacoum presence and effects on non-target marine organisms were investigated. Different fish species were sampled, and a set of analyses was conducted to determine vitamin K and vitamin K epoxide reductase concentrations, prothrombin time, and erythrocytic nuclear abnormalities (ENA) assay. In all the examined organisms, brodifacoum was not detected. The results obtained showed differences in vitamin K and vitamin K epoxide concentrations among the samples studied, with a positive correlation for three species between vitamin K, vitamin K epoxide, and fish weight. The prothrombin time assay showed a good blood clotting capacity in the fish. Higher abnormality values were recorded for four species. The results of this study suggest that it is possible to hypothesize that the sampled fish were not likely to have been exposed to brodifacoum and that consequently there are no negative issues concerning human consumption.
Interstitial Lung Disease in Primary Biliary Cholangitis: A Cohort Prospective Study
Authors: Kalashnikov Michail , Akulkina Larisa , Brovko Michail , Sholomova Viktoria , Yanakaeva Alisa , Abdurakhmanov Dzhamal , Moiseev Sergey
Published: February 2023

Interstitial lung disease (ILD) has been recognized as an extrahepatic manifestation ofprimary biliary cholangitis (PBC), althoughlimited data are available on its prevalence and clinical significance. Therefore, we evaluated the occurrence and clinical features of ILD in a cohort of PBC patients. Ninety-three individuals without concomitant rheumatic diseases were enrolled in our prospective cohort study. All patients underwent chest high-resolution computed tomography (HRCT). Liver-related and lung-related survival wereassessed. A lung-related outcome was defined as death from ILD complications; a liver-related outcome was defined as liver transplantation or death from liver cirrhosis complications. HRCT findings suggestive ofILD were detected in 38 patients (40.9%). A sarcoid-like pattern of PBC-associated ILD was the most frequent, followed by subclinical ILD and organizing pneumonia. Patients with ILD were less likely to have liver cirrhosis and liver-related symptoms and presented with higher serum immunoglobulin M(IgM) and M2 subtype antimitochondrial antibodies (AMA-M2) positivity rates. In a multivariate analysis, the absence of liver disease symptoms at the disease presentation (OR 11.509; 95% CI 1.210–109.421; p = 0.033), the presence of hepatic non-necrotizing epithelioid cell granulomas (OR 17.754; 95% CI 1.805–174.631; p = 0.014), higher serum IgM (OR 1.535; 95% CI 1.067–2.208; p = 0.020) and higher blood leukocyte count (OR 2.356; 95% CI 1.170–4.747; p = 0.016) were independent risk factors associated with ILD in PBC. More than a third of patients with ILD showed no respiratory symptoms, and only one ILD-related death occurred during a follow-up of 29.0 months (IQR 11.5; 38.0). Patients with ILD had better liver transplant-free survival.ILD in PBC had a benign course and was associated with a lower liver disease severity. PBC-associated ILD should be included in a list of differential diagnoses of ILD.
When to Transfer Embryos if There Is Only 1 or 2?
Authors: Stimpfel Martin , Jancar Nina , Ban-Frangez Helena , Vrtacnik-Bokal Eda
Published: February 2023

The latest reports suggest that it is better to transfer embryos to the uterus on day five of preimplantation development compared to other days of development, but it is not clear if this stands when there are only one-two embryos obtained in the cycle. Therefore, to address this issue, we performed a retrospective study of such cycles. Our study included all of the stimulated IVF/ICSI cycles performed at our institution in the period between 1 January 2004 and 31 December 2018 in which one-two embryos were obtained in the IVF/ICSI cycle and met our inclusion criteria, and we compared the data between day three and day five embryo transfer (ET). The analysis revealed that the day three ET group of patients was significantly older (p < 0.001), were administered a significantly higher dose of gonadotrophins (p = 0.015), and retrieved a lower mean number of aspirated oocytes per cycle (p < 0.001) and lower mean number of embryos (p < 0.001). The birth rate per ET was significantly higher in the day five ET group (p = 0.045) and further analysis indicated that this could be due the trend observed in a group of patients under 36 years old, while in older patients there was no such difference. To conclude, our retrospective study indicates that it might be better to perform ET on day five instead of day three when there are only one-two embryos obtained in the cycle, but probably only when patients are under 36 years old.
The Effect of Molecular Hydrogen on Functional States of Erythrocytes in Rats with Simulated Chronic Heart Failure
Authors: Deryugina Anna Vyacheslavovna , Danilova Darya Andreevna , Pichugin Vladimir Viktorovich , Brichkin Yurii Dmitrievich
Published: February 2023

Molecular hydrogen has an anti-inflammatory and cardioprotective effect, which is associated with its antioxidant properties. Erythrocytes are subjected to oxidative stress in pathologies of the cardiovascular system, which is the cause of a violation of the gas transport function of blood and microcirculation. Therefore, our aim was to investigate the effects of H2 inhalation on the functional states of red blood cells (RBCs) in chronic heart failure (CHF) in rats. The markers of lipid peroxidation, antioxidant capacity, electrophoretic mobility of erythrocytes (EPM), aggregation, levels of adenosine triphosphate (ATP) and 2,3-diphosphoglyceric acid (2,3-DPG), hematological parameters were estimated in RBCs. An increase in EPM and a decrease in the level of aggregation were observed in groups with multiple and single H2 application. The orientation of lipoperoxidation processes in erythrocytes was combined with the dynamics of changes in oxidative processes in blood plasma, it was observed with both single and multiple exposures, although the severity of the changes was greater with multiple H2 inhalations. Probably, the antioxidant effects of molecular hydrogen mediate its metabolic action. Based on these data, we conclude the use of H2 improves microcirculation and oxygen transport function of blood and can be effective in the treatment of CHF.
Correlation between Bone Mineral Density and Progression of Hip Osteoarthritis in Adult Men and Women in Bulgaria—Results from a 7-Year Study
Authors: Sapundzhiev Lyubomir , Sapundzhieva Tanya , Mitev Martin , Simitchiev Kiril , Batalov Anastas
Published: February 2023

Changes in clinical presentation, radiographic progression (RP), bone mineral density (BMD), bone turnover (BT), and cartilage turnover (CT) markers were compared in two groups of patients with hip osteoarthritis (HOA) over a period of 7 years. Each group consisted of 150 patients, including a control group on standard-of-care therapy (SC) with simple analgesics and physical exercises, and a study group (SG) on standard-of-care therapy supplemented by vitamin D3 and intravenous administration of zoledronic acid (5 mg) yearly for 3 consecutive years. Patient groups were homogenized regarding the following: (1) radiographic grade (RG), including 75 patients with hip OA RG II according to the Kellgren–Lawrence grading system (K/L), and 75 with RG III on K/L; (2) radiographic model (RM), as each of the K/L grades was subdivided into three subgroups consisting of 25 patients of different RMs: atrophic (‘A’), intermediate (‘I’), and hypertrophic (‘H’); (3) gender-equal ratio of men and women in each subgroup (Female/Male = 15/10). The following parameters were assessed: (1) clinical parameters (CP), pain at walking (WP-VAS 100 mm), functional ability (WOMAC-C), and time to total hip replacement (tTHR); (2) radiographic indicators(RI)—joint space width (JSW) and speed of joint space narrowing (JSN), changes in BMD (DXA), including proximal femur (PF-BMD), lumbar spine (LS-BMD), and total body (TB-BMD); (3) laboratory parameters (LP)—vitamin D3 levels and levels of BT/CT markers. RV were assessed every 12 months, whereas CV/LV were assessed every 6 months. Results: Cross-sectional analysis (CsA) at baseline showed statistically significant differences (SSD) at p < 0.05 in CP (WP, WOMAC-C); BMD of all sites and levels of CT/BT markers between the ‘A’ and ‘H’ RM groups in all patients. Longitudinal analysis (LtA) showed SSD (p < 0.05) between CG and SG in all CP (WP, WOMAC-C, tTHR) parameters of RP (mJSW, JSN), BMD of all sites, and levels of CT/BT markers for all ‘A’ models and in 30% of ‘I’-RMs (those with elevated markers for BT/CT at baseline and during the observation period). Conclusion: The presence of SSD at baseline (‘A’ vs. ‘H’) supported the thesis that at least two different subgroups of HOA exist: one associated with ‘A’ and the other with ‘H’ models. D3 supplementation and the intravenous administration of bisphosphonate were the treatment strategies that slowed down RP and postponed tTHR by over 12 months in the ‘A’ and ‘I’ RM with elevated BT/CT markers.
Comparative Transcriptome Profiles of Human HaCaT Cells in Response to Gynostemma pentaphyllum Extracts Obtained Using Three Independent Methods by RNA Sequencing
Authors: Cho Won Kyong , Paek Seung Hye , Kim Soo-Yun , Jang Sung Joo , Lee Sak , Choi Hoseong , Jo Yeonhwa , Lee Jeong Hun , Moh Sang Hyun
Published: February 2023

Gynostemma pentaphyllum (GP) is widely used in herbal medicine. In this study, we developed a method for the large-scale production of GP cells using plant tissue culture techniques combined with bioreactors. Six metabolites (uridine, adenosine, guanosine, tyrosine, phenylalanine, and tryptophan) were identified in GP extracts. Transcriptome analyses of HaCaT cells treated with GP extracts using three independent methods were conducted. Most differentially expressed genes (DEGs) from the GP-all condition (combination of three GP extracts) showed similar gene expression on treatment with the three individual GP extracts. The most significantly upregulated gene was LTBP1. Additionally, 125 and 51 genes were upregulated and downregulated, respectively, in response to the GP extracts. The upregulated genes were associated with the response to growth factors and heart development. Some of these genes encode components of elastic fibers and the extracellular matrix and are associated with many cancers. Genes related to folate biosynthesis and vitamin D metabolism were also upregulated. In contrast, many downregulated genes were associated with cell adhesion. Moreover, many DEGs were targeted to the synaptic and neuronal projections. Our study has revealed the functional mechanisms of GP extracts’ anti-aging and photoprotective effects on the skin using RNA sequencing.
Relationship Between Retinal Microcirculation and Renal Function in Patients with Diabetes and Chronic Kidney Disease by Laser Speckle Flowgraphy
Authors: Iwase Takeshi , Ueno Yoshitaka , Tomita Ryo , Terasaki Hiroko
Published: February 2023

This study investigated the effect of renal dysfunction categorized by the stage of chronic kidney disease (CKD) on the retinal microcirculation assessed by laser speckle flowgraphy (LSFG) and retinal artery caliber measured by adaptive optics imaging in diabetic patients particularly the early stage of retinopathy and nephropathy. We divided the patients with diabetes into three groups based on the CKD stage (non-CKD (n = 54); CKD stage 1 + 2 (n = 20); CKD stage 3 (n = 41)). The mean blur rate (MBR) of the stage 3 CKD group was significantly lower than that of the no-CKD group (p < 0.015). The total retinal flow index (TRFI) in the stage 3 CKD group was significantly lower than that of the no-CKD group (p < 0.002). Multiple regression analysis demonstrated that CKD stage was independently associated with MBR (β = −0.257, p = 0.031) and TRFI (β = −0.316, p = 0.015). No significant differences were observed in external diameter, lumen diameter, wall thickness, and wall to lumen ratio among the groups. These results indicated that the ONH MBR and TRFI as assessed by LSFG decreases in diabetic patients with stage 3 CKD, but the arterial diameter measured by adaptive optics imaging does not change, suggesting that impaired renal function may be associated with decreased retinal blood flow in early-stage diabetic retinopathy.
Outcome of Partial Adrenalectomy in MEN2 Syndrome: Personal Experience and Systematic Review of Literature
Authors: Procopio Priscilla Francesca , Pennestrì Francesco , De Crea Carmela , Voloudakis Nikolaos , Bellantone Rocco , Raffaelli Marco
Published: February 2023

Background: Partial adrenalectomy (PA) is an alternative option to total adrenalectomy for the treatment of hereditary pheochromocytoma (PHEO) to preserve cortical function and avoid life-long steroid replacement. The aim of this review is to summarize current evidence in terms of clinical outcome, recurrence, and corticosteroid therapy implementation after PA for MEN2-PHEOs. Material and Methods: From a total of 931 adrenalectomies (1997–2022), 16 of the 194 patients who underwent surgical treatment of PHEO had MEN2 syndrome. There were six patients scheduled for PA. MEDLINE®, EMBASE®, Web of Science, and Cochrane Library were searched for English studies from 1981 to 2022. Results: Among six patients who underwent PA for MEN2-related PHEO in our center, we reported two with bilateral synchronous disease and three with metachronous PHEOs. One recurrence was registered. Less than 20 mg/day Hydrocortison therapy was necessary in 50% of patients after bilateral procedures. Systematic review identified 83 PA for MEN2-PHEO. Bilateral synchronous PHEO, metachronous PHEO and disease recurrence were reported in 42%, 26%, and 4% of patients, respectively. Postoperative steroid implementation was necessary in 65% of patients who underwent bilateral procedures. Conclusions: PA seems to be a safe and valuable option for the treatment of MEN2-related PHEOs, balancing the risk of disease recurrence with the need for corticosteroid therapy.
6-Chloro-3-nitro-2-[(phenylsulfonyl)methyl]imidazo[1,2-b]pyridazine
Authors: Paoli-Lombardo Romain , Primas Nicolas , Hutter Sébastien , Bourgeade-Delmas Sandra , Boudot Clotilde , Castera-Ducros Caroline , Jacquet Inès , Courtioux Bertrand , Azas Nadine , Rathelot Pascal , Vanelle Patrice
Published: February 2023

As part of our ongoing scaffold-hopping work on an antikinetoplastid 3-nitroimidazo[1,2-a]pyridine scaffold, we explored 3-nitroimidazo[1,2-b]pyridazine as a potential new antikinetoplastid series. Using conditions previously described by our lab, we obtained 6-chloro-3-nitro-2-[(phenylsulfonyl)methyl]imidazo[1,2-b]pyridazine with 54% yield. In vitro activity of this compound was evaluated against both the promastigote form of Leishmania donovani, the axenic amastigote form of Leishmania infantum and the trypomastigote blood stream form of Trypanosomabrucei brucei, and its influence on cell viability was assessed on the HepG2 cell line. However, despite good activity against the trypomastigote blood stream form of T. b. brucei (EC50 = 0.38 µM), it showed poor solubility in both HepG2 (CC50 > 7.8 µM) and L. infantum axenic amastigotes (EC50 > 1.6 µM) culture media, associated with a loss of activity against the promastigote form of L. infantum (EC50 > 15.6 µM).
An Experimental Study on Torsional Behavior of Reinforced Concrete Columns Retrofitted with Hybrid Concrete Jackets
Authors: Ro Kyong Min , Kim Min Sook , Lee Young Hak
Published: February 2023

The concrete jacketing method for retrofitting old reinforced concrete (RC) columns should secure confinement and seismic performance under torsion as well as unidirectional later loads. In a previous study, a hybrid concrete jacketing method was proposed using steel wire mesh (SWM), steel grid reinforcement (SGR), which can replace reinforcement of existing concrete jacketing method, and using steel fiber non-shrinkage mortar (SFNM). These details can simplify the retrofitting process of the existing concrete jacketing method, and seismic performance was evaluated by conducting a cyclic loading test under unidirectional loading. In this paper, the torsional behavior of RC columns retrofitted with the hybrid concrete jacketing method was investigated. Four specimens were fabricated and conducted cyclic loading tests under two types of loading schemes, unidirectional and bidirectional loading, to examine the effect of the loading path. The strength and energy dissipation capacity of retrofitted columns with hybrid concrete jackets increased approximately eight times compared to the old RC columns under torsional loading. Therefore, the hybrid concrete jacketing method can improve torsional resistance.
Experimental Research on Fatigue Performance of Reinforced Concrete T-Shaped Beams under Corrosion–Fatigue Coupling Action
Authors: Zhang Tian , Zhang Xuefan , Li Pengfei , Li Haijiang , Li Xiaofei , Zou Yunfeng
Published: February 2023

Highway bridges in coastal areas are seriously affected by the marine environment, while most of the existing test methods for bridge-reinforced concrete beams considering both corrosion and fatigue factors are carried out in an alternating manner, which cannot reflect the actual service conditions of the bridge structure. This paper focuses on an experimental study of the coupled influence of reinforcement corrosion and fatigue loading in reinforced concrete T-shaped beams. A novel loading test device that can realize the corrosion–fatigue coupling effect is designed, and then six reinforced concrete T-shaped beams are fabricated and tested. For the corrosion–fatigue coupling test beams, the variation law of beam cracks, failure modes, steel strain development law, load-deflection relationship, and fatigue life are analyzed and compared with that of the simple fatigue test beams. The test results show that the cracks of the test beam develop continuously with the fatigue loading times under the corrosion–fatigue coupling environment. The fatigue failure modes are all brittle fractures of the main steel bars, which present the shape of uneven oblique section tearing. The new testing device and approach can provide direct insights into the interaction of reinforcement corrosion and cyclic loading on the fatigue behavior of T-shaped RC beams, which can be further used to understand the long-term performance of bridge structures under complex marine environments.
Compression Behavior of Concrete Columns Strengthened with Fiber-Reinforced Inorganic Composites Based on Magnesium Phosphate Cement
Authors: Zhang Qihang , Zhang Xin , Liu Qiaoling
Published: February 2023

Fiber-reinforced polymer (FRP) composites have become attractive for strengthening and repairing deteriorated concrete structures. However, their poor high-temperature resistance and durability in some extreme environments, such as frequent water-vapor erosion and temperature changes, limit their application. Magnesium phosphate cement (MPC) has been used to repair damaged concrete due to its excellent high-temperature resistance and durability. Therefore, this paper aims to study the compressive behavior of concrete columns strengthened with fiber-reinforced inorganic polymer (FRiP) composites based on magnesium phosphate cement so as to evaluate the confinement effect. Twenty-one cylindrical specimens were prepared to examine the axial compressive behavior of carbon-fiber-reinforced inorganic polymer (CFRiP) specimens based on magnesium phosphate cement confined by one to three layers of carbon-fiber fabrics. They are compared with concrete specimens strengthened with epoxy-based FRP and unconfined concrete specimens. The test results show that compared with the unconfined concrete specimen, the strength of the CFRiP-strengthened specimens based on magnesium phosphate increases by 1.69–2.50 times, and their ultimate strain is enlarged by 1.83–3.50 times. The strength and ultimate strain of the CFRiP-strengthened specimens based on magnesium phosphate are approximately 95% and 60% of those of the specimens strengthened with epoxy-based FRP, respectively. A semiempirical model of concrete confined by the CFRiP system based on magnesium phosphate cement is also proposed. The theoretical prediction is finally compared with the experimental results, indicating that the developed model provides a prediction close to the test results.
Effect of L-Glutamic Acid on the Composition and Morphology of Nanostructured Calcium Phosphate as Biomaterial
Authors: Takabait Fatah , Martínez-Martínez Sergio , Mahtout Laila , Graba Zahra , Sánchez-Soto Pedro J. , Pérez-Villarejo Luis
Published: February 2023

Calcium phosphate (CaP) with several chemical compositions and morphologies was prepared by precipitation using aqueous solutions of L-Glutamic acid (H2G) and calcium hydroxide, both mixed together with an aqueous solution (0.15 M) of phosphoric acid. Plate-shaped dicalcium phosphate dihydrate (brushite) particles were obtained and identified at a lower concentration of the solution of the reactants. The Ca/P ratio deduced by EDS was ~1, as expected. The nanoscale dimension of carbonate apatite and amorphous calcium phosphate, with variable Ca/P ratios, were revealed by X-ray diffraction (XRD) and scanning electron microscopy and energy dispersive X-ray spectroscopy analysis (SEM-EDS). They were characterized in medium and high concentrations of calcium hydroxide (0.15 M and 0.20 M). The equilibria involved in all the reactions in aqueous solution were determined. The thermodynamic calculations showed a decrease in the amount of chelate complexes with an increase in pH, being the opposite of [CaPO4−] and [CaHG+]. This fluctuation showed an evident influence on the morphology and polymorphism of CaP particles obtained under the present experimental conditions, with potential use as a biomaterial.
The Structure and Properties of Laser-Cladded Inconel 625/TiC Composite Coatings
Authors: Poloczek Tomasz , Lont Aleksandra , Górka Jacek
Published: February 2023

This article presents production results concerning metal matrix composite-coatings made using the laser-cladding technology. The enhancement of the wear resistance of the material surface is the one of the main goals accompanying the manufacturing of composite coatings. Nickel-based superalloys are used in several industries because they are characterized by a number of desirable properties including high tensile and fatigue strength as well as resistance to high-temperature corrosion in aggressive environments. One of the most interesting materials from the group of superalloys is Inconel 625, used as a matrix material in tests discussed in this article. However, nickel-based superalloys are also characterized by an insufficient wear resistance of the surface, therefore, in relation to the tests discussed in this article, Inconel 625-based composite coatings were reinforced by adding 10%, 20% and 40% of titanium carbide particles. The addition of hard phases, i.e., TiC, WC or SiC particles can have a positive effect on the erosion resistance of cladded specimens. The aim of the experiment was to determine the impact of the titanium carbide content on the structure of the alloy and its resistance to corrosive wear, enabling the extension of the service life of Inconel 625/TiC composite coatings. The investigation included microhardness tests, corrosion resistance analysis, penetrant tests, macrostructure and microstructure analyses and X-ray diffraction (XRD) tests. The TiC particles increased the hardness of the coatings and, in general, had a negative impact on the corrosion resistance of pure Inconel 625 coatings. However, the increased homogeneity of composite coatings translated into the improvement of corrosion resistance.
Sub-ps Laser Deposited Copper Films for Application in RF Guns
Authors: Lorusso Antonella , Kovács Zsolt , Gilicze Barnabás , Szatmári Sándor , Perrone Alessio , Szörényi Tamás
Published: February 2023

Copper thin films are intended to serve as a cover layer of photocathodes that are deposited by ablating copper targets in a high vacuum by temporally clean 600 fs laser pulses at 248 nm. The extremely forward-peaked plume produced by the ultrashort UV pulses of high-energy contrast ensures fast film growth. The deposition rate, defined as peak thickness per number of pulses, rises from 0.03 to 0.11 nm/pulse with an increasing ablated area while keeping the pulse energy constant. The material distribution over the surface-to-be-coated can also effectively be controlled by tuning the dimensions of the ablated area: surface patterning from airbrush-like to broad strokes is available. The well-adhering films of uniform surface morphology consist of densely packed lentil-like particles of several hundred nm in diameter and several ten nm in height. Task-optimized ultrashort UV laser deposition is thereby an effective approach for the production of thin film patterns of predetermined geometry, serving e.g., as critical parts of photocathodes.
Q-Learning with the Variable Box Method: A Case Study to Land a Solid Rocket
Authors: Tevera-Ruiz Alejandro , Garcia-Rodriguez Rodolfo , Parra-Vega Vicente , Ramos-Velasco Luis Enrique
Published: February 2023

Some critical tasks require refined actions near the target, for instance, steering a car in a crowded parking lot or landing a rocket. These tasks are critical because failure to comply with the constraints near the target may lead to a fatal (unrecoverable) condition. Thus, a higher resolution action is required near the target to increase maneuvering precision. Moreover, completing the task becomes more challenging if the environment changes or is uncertain. Therefore, novel approaches have been proposed for these problems. In particular, reinforcement learning schemes such as Q-learning have been suggested to learn from scratch, subject to exploring action–state causal relationships aimed at action decisions that lead to an increase in the reward. Q-learning refines iterative action inputs by exploring state spaces that maximize the reward. However, reducing the (constant) resolution box needed for critical tasks increases the computational load, which may lead to the tantamount curse of the dimensionality problem. This paper proposes a variable box method to maintain a low number of boxes but reduce its resolution only near the target to increase action resolution as needed. The proposal is applied to a critical task such as landing a solid rocket, whose dynamics are highly nonlinear, underactuated, non-affine, and subject to environmental disturbances. Simulations show successful landing without leading to a curse of dimensionality, typical of the classical (constant box) Q-learning scheme.
A Dynamic Self-Attention-Based Fault Diagnosis Method for Belt Conveyor Idlers
Authors: Liu Yi , Miao Changyun , Li Xianguo , Ji Jianhua , Meng Dejun , Wang Yimin
Published: February 2023

Idlers are typical rotating parts of a belt conveyor carrying the conveyor belt and materials. The complex operating noise and unstable features lead to poor accuracy of sound-based idler fault diagnosis. This paper proposes a fault diagnosis method for belt conveyor idlers based on Transformer’s dynamic self-attention (DSA). Firstly, the A-weighted time-frequency spectrum of the idler sound is extracted as the input. Secondly, based on the DSA block, the multi-frequency cross-correlation DSA algorithm is designed to extract the cross-correlation features between different frequency bands in the input feature map, and the global DSA algorithm is applied to perceive and enhance the global correlation features in parallel. Finally, the cross-correlation and global correlation features are concatenated and linearly projected into a fault-type space to diagnose typical bearing and roller faults of idlers. The method makes full use of the relevant information scattered in different frequency bands of the idler running sound under complex working conditions and reduces the negative effect of the strong running noise on the extraction of weak fault features. Experimental results show that the fault diagnosis accuracy is 94.6% and the latency is 27.8 ms.
The History of a Lemma from Archimedes to Newton
Authors: Florio Emilia
Published: February 2023

In this work, we identify some traces of the history of Archimedes’ straight line, a lemma introduced by Archimedes within the solution of prop. II 4 of On the Sphere and Cylinder, in which it is asked to cut a sphere with a plane in order to obtain two spherical segments such that their ratio is equal to a given ratio. In the course of solving this proposition with the method of analysis, assuming given what is required, as specified in this method, Archimedes traces the path along which one goes in search of the final point, from which what is required comes, expressed in a lemma which in history is referred to as Archimedes’ straight line or the square problem. The Syracusan mathematician promised to later give a solution to the lemma, but he did not keep his promise. The lemma was taken up again by Eutocius of Ascalon towards the end of the Hellenistic period, it had considerable resonance among some Arab mathematicians, who traced a specific line of research around it, finally finding attention in the Latin tradition up to Newton within the first part of the history of the path of the analytic method.
A Mode-Matching Tailored-Galerkin Approach for Higher Order Interface Conditions and Geometric Variations
Authors: Afzal Muhammad , Akhtar Naveed , Alkinidri Mohammed Omar , Shutaywi Meshal
Published: February 2023

The current study focuses on the modeling and analysis of acoustic scattering from an elastic membrane disc located in a cylindrical waveguide that may involve structural discontinuities. The physical problem is governed by Helmholtz’s equation and involves higher order boundary conditions at the interfaces. The Mode-Matching (MM) method in conjunction with Galerkin formulation is developed to solve the governing boundary value problems. The solution procedure is first applied on two prototype problems to formulate the theoretical frame work, which is then used to analyze the structural response of the elastic membranes attached at the mouth of the cylindrical expansion chamber. The aforementioned solution method yields the linear algebraic systems containing infinite equations. These systems are truncated first and then are numerically solved. From the numerical experiments, it is found that geometrical and material properties of the structure significantly affect the transmission loss as well as the scattering energies.
Red Marine Algae Lithothamnion calcareum Supports Dental Enamel Mineralization
Authors: R. Carrilho Marcela , Bretz Walter
Published: February 2023

The current management of oral conditions such as dental caries and erosion mostly relies on fluoride-based formulations. Herein, we proposed the use of the remaining skeleton of Lithothamnion calcareum (LC) as an alternative to fluorides. LC is a red macroalgae of the Corallinales order, occurring in the northeast coast of Brazil, whose unique feature is the abundant presence of calcium carbonates in its cell walls. Two experimental approaches tested the general hypothesis that LC could mediate enamel de-remineralization dynamics as efficiently as fluorides. Firstly, the effect of LC on enamel de-mineralization was determined in vitro by microhardness and gravimetric measurements to test the hypothesis that LC could either prevent calcium/phosphate release from intact enamel or facilitate calcium/phosphate reprecipitation on an artificially demineralized enamel surface. Subsequently, an in situ/ex vivo co-twin control study measured the effect of LC on the remineralization of chemical-demineralized enamel using microhardness and quantitative light-induced fluorescence. With this second experiment, we wanted to test whether outcomes obtained in experiment 1 would be confirmed by an in situ/ex vivo co-twin control model. Both experiments showed that LC exhibited equivalent or superior ability to modulate enamel de-remineralization when compared to fluoride solution. LC should be explored as an alternative to manage oral conditions involving the enamel demineralization.
Nonlinear Modeling of an Automotive Air Conditioning System Considering Active Grille Shutters
Authors: Parent Trevor , Defoe Jeffrey J. , Rahimi Afshin
Published: February 2023

This paper expands upon the state of the art in nonlinear modeling of automotive air conditioning systems. Prior models considered only the effects of the refrigerant compressor and the condenser fan. There are two new aspects included here. First, we create a mathematical model for front-end underhood airflow, considering vehicle speed, condenser fan rotational speed, and active grille shutter position. In addition, we present a new model for the power consumption of the vehicle associated with aerodynamic drag caused by underhood flow, as well as a fan power model which accounts not only for changes in rotational speed but also changes in flow rate. The models developed in this paper are coded in MATLAB/Simulink and assessed for various vehicle driving conditions against a higher-fidelity vehicle energy management model, showing good agreement. By including the active grille shutters as a controllable actuator and the impact of underhood flow on vehicle drag and fan power consumption, control schemes can be developed to holistically target reduced energy consumption for the air conditioning system and, thus, improve the overall vehicle energy efficiency.