bluuebunny/crossref_metadata_2025 huggingface dataset:
IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?
Authors: Pellefigues Christophe
Published: September 2020

Atopic dermatitis (AD) is a common skin disease affecting 20% of the population beginning usually before one year of age. It is associated with the emergence of allergen-specific IgE, but also with autoreactive IgE, whose function remain elusive. This review discusses current knowledge relevant to the mechanisms, which leads to the secretion of autoreactive IgE and to the potential function of these antibodies in AD. Multiple autoantigens have been described to elicit an IgE-dependent response in this context. This IgE autoimmunity starts in infancy and is associated with disease severity. Furthermore, the overall prevalence of autoreactive IgE to multiple auto-antigens is high in AD patients. IgE-antigen complexes can promote a facilitated antigen presentation, a skewing of the adaptive response toward type 2 immunity, and a chronic skin barrier dysfunction and inflammation in patients or AD models. In AD, skin barrier defects and the atopic immune environment facilitate allergen sensitization and the development of other IgE-mediated allergic diseases in a process called the atopic march. AD is also associated epidemiologically with several autoimmune diseases showing autoreactive IgE secretion. Thus, a potential outcome of IgE autoreactivity in AD could be the development of further autoimmune diseases.
A New Water-Soluble Bactericidal Agent for the Treatment of Infections Caused by Gram-Positive and Gram-Negative Bacterial Strains
Authors: Presentato Alessandro , Piacenza Elena , Scurria Antonino , Albanese Lorenzo , Zabini Federica , Meneguzzo Francesco , Nuzzo Domenico , Pagliaro Mario , Martino Delia Chillura , Alduina Rosa , Ciriminna Rosaria
Published: September 2020

Grapefruit and lemon pectin obtained from the respective waste citrus peels via hydrodynamic cavitation in water only are powerful, broad-scope antimicrobials against Gram-negative and -positive bacteria. Dubbed IntegroPectin, these pectic polymers functionalized with citrus flavonoids and terpenes show superior antimicrobial activity when compared to commercial citrus pectin. Similar to commercial pectin, lemon IntegroPectin determined ca. 3-log reduction in Staphylococcus aureus cells, while an enhanced activity of commercial citrus pectin was detected in the case of Pseudomonas aeruginosa cells with a minimal bactericidal concentration (MBC) of 15 mg mL−1. Although grapefruit and lemon IntegroPectin share equal MBC in the case of P. aeruginosa cells, grapefruit IntegroPectin shows boosted activity upon exposure of S. aureus cells with a 40 mg mL−1 biopolymer concentration affording complete killing of the bacterial cells. Insights into the mechanism of action of these biocompatible antimicrobials and their effect on bacterial cells, at the morphological level, were obtained indirectly through Fourier Transform Infrared spectroscopy and directly through scanning electron microscopy. In the era of antimicrobial resistance, these results are of great societal and sanitary relevance since citrus IntegroPectin biomaterials are also devoid of cytotoxic activity, as already shown for lemon IntegroPectin, opening the route to the development of new medical treatments of polymicrobial infections unlikely to develop drug resistance.
Different Nitro-Oxidative Response of Odontarrhena lesbiaca Plants from Geographically Separated Habitats to Excess Nickel
Authors: Feigl Gábor , Varga Viktória , Molnár Árpád , Dimitrakopoulos Panayiotis G. , Kolbert Zsuzsanna
Published: September 2020

Odontarrhena lesbiaca is an endemic species to the serpentine soils of Lesbos Island (Greece). As a nickel (Ni) hyperaccumulator, it possesses an exceptional Ni tolerance; and it can accumulate up to 0.2–2.4% Ni of its leaves’ dry weight. In our study, O. lesbiaca seeds from two geographically separated study sites (Ampeliko and Loutra) were germinated and grown on control and Ni-containing (3000 mg/kg) soil in a rhizotron system. Ni excess induced significant Ni uptake and translocation in both O. lesbiaca ecotypes and affected their root architecture differently: plants from the Ampeliko site proved to be more tolerant; since their root growth was less inhibited compared to plants originated from the Loutra site. In the roots of the Ampeliko ecotype nitric oxide (NO) was being accumulated, while the degree of protein tyrosine nitration decreased; suggesting that NO in this case acts as a signaling molecule. Moreover, the detected decrease in protein tyrosine nitration may serve as an indicator of this ecotype’s better relative tolerance compared to the more sensitive plants originated from Loutra. Results suggest that Ni hypertolerance and the ability of hyperaccumulation might be connected to the plants’ capability of maintaining their nitrosative balance; yet, relatively little is known about the relationship between excess Ni, tolerance mechanisms and the balance of reactive nitrogen species in plants so far.
Properties of Foamed Lightweight High-Performance Phosphogypsum-Based Ternary System Binder
Authors: Bumanis Girts , Zorica Jelizaveta , Bajare Diana
Published: September 2020

The potential of phosphogypsum (PG) as secondary raw material in construction industry is high if compared to other raw materials from the point of view of availability, total energy consumption, and CO2 emissions created during material processing. This work investigates a green hydraulic ternary system binder based on waste phosphogypsum (PG) for the development of sustainable high-performance construction materials. Moreover, a simple, reproducible, and low-cost manufacture is followed by reaching PG utilization up to 50 wt.% of the binder. Commercial gypsum plaster was used for comparison. High-performance binder was obtained and on a basis of it foamed lightweight material was developed. Low water-binder ratio mixture compositions were prepared. Binder paste, mortar, and foamed binder were used for sample preparation. Chemical, mineralogical composition and performance of the binder were evaluated. Results indicate that the used waste may be successfully employed to produce high-performance binder pastes and even mortars with a compression strength up to 90 MPa. With the use of foaming agent, lightweight (370–700 kg/m3) foam concrete was produced with a thermal conductivity from 0.086 to 0.153 W/mK. Water tightness (softening coefficient) of such foamed material was 0.5–0.64. Proposed approach represents a viable solution to reduce the environmental footprint associated with waste disposal.
A Conflict Duration Graph-Based Coordination Method for Connected and Automated Vehicles at Signal-Free Intersections
Authors: Deng Zhiyun , Shi Yanjun , Han Qiaomei , Lv Lingling , Shen Weiming
Published: September 2020

Previous studies on Connected and Automated Vehicles (CAVs) demonstrated the potential to coordinate the behaviors of multiple connected vehicles for traffic improvements. In this paper, we first propose a Conflict Duration Graph-based (CDG-based) coordination framework to resolve collisions and improve the traffic capacity of signal-free intersections. Secondly, a Speed Control-based Intersection Coordination Model (SICM) is developed to identify complex constraints in multi-vehicle collision scenarios. Thirdly, a geometric Translation-based Intersection Coordination Algorithm (TICA) is proposed to calculate the ideal location of time blocks in CDGs and then obtain the near-optimal design speed in the form of combinatorial optimization. Twelve groups of test scenarios with different traffic volumes were designed and tested on a MATLAB-based simulation platform. Simulation results showed that the proposed method can resolve all the collisions and instruct the vehicles to pass signal-free intersections collaboratively without stopping in low to medium level of congestion.
Salivary Redox Biomarkers in the Course of Caries and Periodontal Disease
Authors: Skutnik-Radziszewska Anna , Zalewska Anna
Published: September 2020

Caries are a pathological process of extracorporeal nature, characterized by demineralization of inorganic substances as well as proteolysis triggered by acids produced by bacteria present in dental plaque, as a result of metabolism of sugars of both external and internal origin. Periodontal disease, on the other hand, is a multifactorial degenerative disease associated with inflammation, involving a group of tissues that surround the dental cervix and root of the tooth. It is believed that one of the mechanisms in the etiopathogenesis of caries and periodontitis are disorders of local and/or general oxidative stress (OS) parameters. Numerous clinical studies have confirmed the relationship between oxidative stress markers and oral diseases. In most analyzed studies, technical and biological variability was so high that none of the markers so far has proven suitable for routine clinical use. The aim of systematic reviews of the literature is to present the existing studies on OS parameters, mainly concerning the activity of antioxidant enzymes in saliva of patients with caries and periodontitis.
The Pathophysiological Significance of Fibulin-3
Authors: Livingstone Imogen , Uversky Vladimir N. , Furniss Dominic , Wiberg Akira
Published: September 2020

Fibulin-3 (also known as EGF-containing fibulin extracellular matrix protein 1 (EFEMP1)) is a secreted extracellular matrix glycoprotein, encoded by the EFEMP1 gene that belongs to the eight-membered fibulin protein family. It has emerged as a functionally unique member of this family, with a diverse array of pathophysiological associations predominantly centered on its role as a modulator of extracellular matrix (ECM) biology. Fibulin-3 is widely expressed in the human body, especially in elastic-fibre-rich tissues and ocular structures, and interacts with enzymatic ECM regulators, including tissue inhibitor of metalloproteinase-3 (TIMP-3). A point mutation in EFEMP1 causes an inherited early-onset form of macular degeneration called Malattia Leventinese/Doyne honeycomb retinal dystrophy (ML/DHRD). EFEMP1 genetic variants have also been associated in genome-wide association studies with numerous complex inherited phenotypes, both physiological (namely, developmental anthropometric traits) and pathological (many of which involve abnormalities of connective tissue function). Furthermore, EFEMP1 expression changes are implicated in the progression of numerous types of cancer, an area in which fibulin-3 has putative significance as a therapeutic target. Here we discuss the potential mechanistic roles of fibulin-3 in these pathologies and highlight how it may contribute to the development, structural integrity, and emergent functionality of the ECM and connective tissues across a range of anatomical locations. Its myriad of aetiological roles positions fibulin-3 as a molecule of interest across numerous research fields and may inform our future understanding and therapeutic approach to many human diseases in clinical settings.
Transient Effect at the Onset of Human Running
Authors: Weich Christian , Vieten Manfred M. , Jensen Randall L.
Published: September 2020

While training and competing as a runner, athletes often sense an unsteady feeling during the first meters on the road. This sensation, termed as transient effect, disappears after a short period as the runners approach their individual running rhythm. The foundation of this work focuses on the detection and quantification of this phenomenon. Thirty athletes ran two sessions over 60 min on a treadmill at moderate speed. Three-dimensional acceleration data were collected using two MEMS sensors attached to the lower limbs. By using the attractor method and Fourier transforms, the transient effect was isolated from noise and further components of human cyclic motion. A substantial transient effect was detected in 81% of all measured runs. On average, the transient effect lasted 5.25 min with a range of less than one minute to a maximum of 31 min. A link to performance data such as running level, experience and weekly training hours could not be found. The presented work provides the methodological basis to detect and quantify the transient effect at moderate running speeds. The acquisition of further physical or metabolic performance data could provide more detailed information about the impact of the transient effect on athletic performance.
Interaction of Polyoxometalates and Nanoparticles with Collector Surfaces—Focus on the Use of Streaming Current Measurements at Flat Surfaces
Authors: Lützenkirchen Johannes , Darbha Gopala Krishna , Chakravadhanula Venkata Sai Kiran , Redel Engelbert , Selmani Atiđa , Vayssières Lionel
Published: September 2020

Streaming current measurements were used to study the interaction of polyoxometalates (POMs) and nanoparticles (NPs) with flat surfaces as an alternative, innovative approach to infer POM and NP properties of potential sparse material in terms of charge and magnitude. With respect to POMs, the approach was able to reveal subtle details of charging properties of +7 vs. +8 charge at very low POM concentrations. For NPs, the sign of charge and even the zeta-potential curve was retrieved. Concerning NPs, mutual interaction between TiO2 and SiO2 surfaces was studied in some detail via macroscopic measurements. Post-mortem analysis of samples from electrokinetic studies and separate investigations via AFM and HRTEM verified the interactions between TiO2 NPs and SiO2 collector surfaces. The interactions in the SiO2/TiO2 system depend to some extent on NP morphology, but in all our systems, irreversible interactions were observed, which would make the studied types of NPs immobile in natural environments. Overall, we conclude that the measurement of streaming currents at flat surfaces is valuable (i) to study NP and POM collector surface interactions and (ii) to simultaneously collect NPs or POM (or other small mobile clusters) for further (structural, morphological or release) investigations.
Pseudolymphomatous Granuloma Annulare: A Case Report
Authors: André Raphaël , Ibrahim Yasmine , Hsieh Aurélie , Kaya Gürkan
Published: September 2020

Granuloma annulare is an idiopathic granulomatous condition. Clinical variants of granuloma annulare include classical and localized, large erythematous patch, generalized, perforating, and subcutaneous/deep forms. Rarely, granuloma annulare shows a prominent lymphoid infiltration. This form is called pseudolymphomatous granuloma annulare. Here, we describe a new case of pseudolymphomatous granuloma annulare.
IoT-Oriented Design of an Associative Memory Based on Impulsive Hopfield Neural Network with Rate Coding of LIF Oscillators
Authors: Boriskov Petr
Published: September 2020

The smart devices in Internet of Things (IoT) need more effective data storage opportunities, as well as support for Artificial Intelligence (AI) methods such as neural networks (NNs). This study presents a design of new associative memory in the form of impulsive Hopfield network based on leaky integrated-and-fire (LIF) RC oscillators with frequency control and hybrid analog–digital coding. Two variants of the network schemes have been developed, where spiking frequencies of oscillators are controlled either by supply currents or by variable resistances. The principle of operation of impulsive networks based on these schemes is presented and the recognition dynamics using simple two-dimensional images in gray gradation as an example is analyzed. A fast digital recognition method is proposed that uses the thresholds of zero crossing of output voltages of neurons. The time scale of this method is compared with the execution time of some network algorithms on IoT devices for moderate data amounts. The proposed Hopfield algorithm uses rate coding to expand the capabilities of neuromorphic engineering, including the design of new hardware circuits of IoT.
A Multi-Criteria Evaluation of the Effectiveness of Nitrogen and Sulfur Fertilization in Different Cultivars of Winter Rapeseed—Productivity, Economic and Energy Balance
Authors: Groth Dariusz Antoni , Sokólski Mateusz , Jankowski Krzysztof Józef
Published: September 2020

This article presents the results of a three-year experiment involving a multi-criteria evaluation (productivity, economic and energy balance) of the effectiveness of nitrogen (N) and sulfur (S) fertilization in different cultivars of winter oilseed rape (open-pollinated, semi-dwarf hybrid, long-stem hybrid) grown in north-eastern (NE) Poland. The yield of the semi-dwarf cultivar was 11% lower than the yield of the long-stem hybrid cultivar and 18% higher than the yield of the open-pollinated cultivar. In all cultivars, N fertilization improved yields up to a rate of 180 kg ha−1 and up to a rate of 230 kg ha−1 in years with low precipitation in spring and summer. Seed yield increased in all cultivars in response to S fertilization at 40 kg ha−1. Higher rates of N fertilizer decreased the content of crude fat and glucosinolates (GLS) and increased the concentration of total protein in all cultivars. Sulfur fertilization increased the content of total protein (in long-stem cultivars) and GLS (in all cultivars). Production costs ranged from €542–624 ha−1 (≤130 kg N ha−1) to €619–697 ha−1 (≥180 kg N ha−1). The demand for energy in the production of winter rapeseed ranged from 14.5–19.3 GJ ha−1 (≤130 kg N ha−1) to 22.4–27.0 GJ ha−1 (≥180 kg N ha−1).
Parametric Study of Various Thermodynamic Cycles for the Use of Unconventional Blends
Authors: Alrebei Odi Fawwaz , Bowen Philip , Valera Medina Agustin
Published: September 2020

This paper aims to conduct a parametric study for five gas turbine cycles (namely, simple, heat exchanged, free turbine and simple cycle, evaporative, and humidified) using a CO2-argon-steam-oxyfuel (CARSOXY) mixture as a working fluid to identify their optimal working conditions with respect to cycle efficiency and specific work output. The performance of the five cycles using CARSOXY is estimated for wet and dry compression, and a cycle is suggested for each range of working conditions. The results of this paper are based on MATLAB codes, which have been developed to conduct the cycle analysis for CARSOXY gas turbines, assuming a stoichiometric condition with an equivalence ratio of 1.0. Analyses are based on the higher heating value (HHV) of methane as fuel. This paper also identifies domains of operating conditions for each cycle, where the efficiency of CARSOXY cycles can be increased by up to 12% compared to air-driven cycles. The CARSOXY heat exchanged cycle has the highest efficiency among the other CARSOXY cycles in the compressor pressure ratio domain of 2–3 and 6–10, whereas, at 3–6, the humidified cycle has the highest efficiency. The evaporative cycle has intermediate efficiency values, while the simple cycle and the free turbine-simple cycle have the lowest efficiencies amongst the five cycles. Additionally, a 10% increase in the cycle efficiency can be theoretically achieved by using the newly suggested CARSOXY blend that has the molar fractions of 47% argon, 10% carbon dioxide, 10% H2O, and 33% oxyfuel at low compressor inlet temperatures, thus theoretically enabling the use of carbon capture technologies.
Numerical Studies on the Performance of the PCM Mesh-Finned Heat Sink Base on Thermal-Flow Multiphysics Coupling Simulation
Authors: Liu Jiefeng , Yu Shangxin , Yang Shichang , Zhang Yiyi , Fan Xianhao , Gao Bing
Published: September 2020

Operating temperature is an important parameter of thyristors to ensure the stable operation of power electronic devices. Thermal management technology is of great significance for improving the reliability of thyristors. In this study, the performance of a phase change material (PCM) mesh-finned heat sink is investigated for the thermal management of thyristors. A multi-physical coupling model of the PCM mesh-finned heat sink is established to analyze the effects of different power losses, air velocities, heights of fins, and thickness of PCM on the thermal performance of the PCM heat sink. The influence of thermal and flow fields on PCM is considered in this model. Furthermore, the heat sink design is optimized to improve the thermal performance based on the calculation results of thermal network parameters. The results show that the power losses, the air velocity, the height of fins, and the thickness of PCM significantly affect the protection ability of the PCM heat sink. After optimizing the heat sink, the PCM heat sink provides 80 s protection time and 100 s recovery time. The PCM mesh-finned heat sink demonstrated good potential for the thermal management of thyristors.
Paper Mill Sludge as a Source of Sugars for Use in the Production of Bioethanol and Isoprene
Authors: Duncan Shona M. , Alkasrawi Malek , Gurram Raghu , Almomani Fares , Wiberley-Bradford Amy E , Singsaas Eric
Published: September 2020

Paper mill sludge (PMS) solids are predominantly comprised of cellulosic fibers and fillers rejected during the pulping or paper making process. Most sludges are dewatered and discharged into landfills or land spread at a cost to the mill; creating large economic and environmental burdens. This lignocellulosic residual stream can be used as a source of sugars for microbial fermentation to renewable chemicals. The aim of this study was to determine the possibility of converting mill sludge to sugars and then fermentation to either isoprene or ethanol. Chemical analysis indicated that the cellulosic fiber composition between 28 to 68% and hemicellulose content ranged from 8.4 to 10.7%. Calcium carbonate concentration in the sludge ranged from 0.4 to 34%. Sludge samples were enzyme hydrolyzed to convert cellulose fibers to glucose, percent conversion ranged from 10.5 to 98%. Calcium carbonate present with the sludge resulted in low hydrolysis rates; washing of sludge with hydrochloric acid to neutralize the calcium carbonate, increased hydrolysis rates by 50 to 88%. The production of isoprene “very low” (190 to 470 nmol) because the isoprene yields were little. Using an industrial yeast strain for fermentation of the sludge sugars obtained from all sludge samples, the maximum conversion efficiency was achieved with productivity ranging from 0.18 to 1.64 g L−1 h−1. Our data demonstrates that PMS can be converted into sugars that can be fermented to renewable chemicals for industry.
Impact of First Tower Earthing Resistance on Fast Front Back-Flashover in a 66 kV Transmission System
Authors: Moselhy Abdullah H. , Abdel-Aziz Abdelaziz M. , Gilany Mahmoud , Emam Ahmed
Published: September 2020

Lightning stroke on a transmission tower structure is one of the major reasons that results in high voltages at the tower arms due to the excessive lightning current flowing through the transmission tower to earth. The Surge voltage seen at the tower cross arm on the first tower close to a substation is the worst case. If this voltage is higher than the withstand level of the insulator string, the insulation of substation equipment will be exposed to transient over-voltage called fast front back-flashover (FFBF). The peak of this transient overvoltage is affected by the value of the system’s earthing resistance. This paper studies the effect of reducing the grounding resistance of both the surge arrestor (SA) and the first transmission line tower adjacent to a 66 kV substation on FFBF. Three case studies using PSCAD/EMTDC software are presented to simulate the variation of the potential sire at the substation equipment with different resistance values for the first tower and SA earthing resistance. The paper also addresses the economic protection system for solving the problem of transient overvoltage. The study proves that the proper design of the first tower grounding system enhances the safety of the system and reduces the cost for the grounding system to the minimum.
Flexibility of CFB Combustion: An Investigation of Co-Combustion with Biomass and RDF at Part Load in Pilot Scale
Authors: Peters Jens , May Jan , Ströhle Jochen , Epple Bernd
Published: September 2020

Co-combustion of biomass and solid fuels from wastes in existing highly efficient power plants is a low-cost solution that can be applied quickly and with low effort to mitigate climate change. Circulating fluidized bed combustion has several advantages when it comes to co-combustion, such as high fuel flexibility. The operational flexibility of circulating fluidized bed (CFB) co-combustion is investigated in a 1 MWth pilot plant. Straw pellets and refuse-derived fuel (RDF) are co-combusted with lignite at full load and part loads. This study focusses on the impact on the hydrodynamic conditions in the fluidized bed, on the heat transfer to the water/steam side of the boiler, and on the flue gas composition. The study demonstrates the flexibility of CFB combustion for three low-rank fuels that differ greatly in their properties. The co-combustion of RDF and straw does not have a negative effect on hydrodynamic stability. How the hydrodynamic conditions determine the temperature and pressure development along the furnace height is shown. The heat transfer in the furnace linearly depends on the thermal load. It increases slightly with an increasing share of straw and the influence of the hydrodynamic conditions on the heat transfer was low.
Electromagnetic Shielding Effect of a Canned Permanent Magnet Motor
Authors: Hu Kun , Zhuang Haijun , Yu Qiang
Published: September 2020

Due to use of the metallic cans in the air gap, the electromagnetic shielding effect is formed, which is the prominent characteristic of the canned motor. In the flux field, eddy current induction occurs on both cans that thus affects the characteristic of the air gap flux field, and generates a loss that is the highest loss of the canned motor. In this paper, a combination method is proposed and stressed to analyze the shielding effect, based on a typical canned permanent magnet synchronous motor. First, the dq vector decomposition of the eddy current is studied. Second, the effect of the load angle on the loss distribution is studied. Finally, compared with the ordinary motor, the feature of can loss due to rotor speed and conductivity variation is shown. The three-dimensional finite element method is adopted, considering the end effect.
Pore-Scale Analysis of Condensate Blockage Mitigation by Wettability Alteration
Authors: Reis Paula K. P. , Carvalho Marcio S.
Published: September 2020

Liquid banking in the near wellbore region can lessen significantly the production from gas reservoirs. As reservoir rocks commonly consist of liquid-wet porous media, they are prone to liquid trapping following well liquid invasion and/or condensate dropout in gas-condensate systems. For this reason, wettability alteration from liquid to gas-wet has been investigated in the past two decades as a permanent gas flow enhancement solution. Numerous experiments suggest flow improvement for immiscible gas-liquid flow in wettability altered cores. However, due to experimental limitations, few studies evaluate the method’s performance for condensing flows, typical of gas-condensate reservoirs. In this context, we present a compositional pore-network model for gas-condensate flow under variable wetting conditions. Different condensate modes and flow patterns based on experimental observations were implemented in the model so that the effects of wettability on condensing flow were represented. Flow analyses under several thermodynamic conditions and flow rates in a sandstone based network were conducted to determine the parameters affecting condensate blockage mitigation by wettability alteration. Relative permeability curves and impacts factors were calculated for gas flowing velocities between 7.5 and 150 m/day, contact angles between 45° and 135°, and condensate saturations up to 35%. Significantly different relative permeability curves were obtained for contrasting wettability media and impact factors below one were found at low flowing velocities in preferentially gas-wet cases. Results exhibited similar trends observed in coreflooding experiments and windows of optimal flow enhancement through wettability alteration were identified.
Effectiveness of Aqueous Chlorine Dioxide in Minimizing Food Safety Risk Associated with Salmonella, E. coli O157:H7, and Listeria monocytogenes on Sweet Potatoes
Authors: Luu Phillip , Chhetri Vijay Singh , Janes Marlene E. , King Joan M. , Adhikari Achyut
Published: September 2020

Sodium hypochlorite (NaOCl) is a commonly used sanitizer in the produce industry despite its limited effectiveness against contaminated human pathogens in fresh produce. Aqueous chlorine dioxide (ClO2) is an alternative sanitizer offering a greater oxidizing potency with greater efficacy in reducing a large number of microorganisms. We investigated the effect of aqueous chlorine dioxide treatment against human pathogens, Salmonella, Escherichia coli O157:H7, and Listeria monocytogenes seeded on sweet potatoes. Sweet potatoes were spot inoculated (4.2 to 5.7 log CFU/cm2) with multi-strain cocktails of Salmonella spp., E. coli O157:H7, and L. monocytogenes and treated for 10–30 min with 5 ppm aqueous ClO2 or water. Aqueous ClO2 treatment was significantly (p < 0.05) effective in reducing Salmonella with a reduction of 2.14 log CFU/cm2 within 20 min compared to 1.44 log CFU/cm2 for water treatment. Similar results were observed for L. monocytogenes with a 1.98 log CFU/cm2 reduction compared to 0.49 log CFU/cm2 reduction observed after 30 min treatment with aqueous ClO2 the water respectively. The maximum reduction in E. coli O157: H7 reached 2.1 Log CFU/cm2 after 20 min of treatment with aqueous ClO2. The level of the pathogens in ClO2 wash solutions, after the treatment, was below the detectable limit. While in the water wash solutions, the pathogens’ populations ranged from 3.47 to 4.63 log CFU/mL. Our study indicates that aqueous ClO2 is highly effective in controlling cross-contamination during postharvest washing of sweet potatoes.
Embarkation: Reimagining a Taoist Ritual Ceremony
Authors: Pai Shin Yu
Published: September 2020

Poet and artist Shin Yu Pai shares the origins and process of creating her performance video piece Embarkation. Informed by Buddhist and Taoist rituals from Bhutan and Taiwan, Pai reflects on her efforts to reimagine a traditional Taoist ceremony in the context of a personal grief ritual performed for the stage. She discusses the process of collaborating with film, video, theater, and movement artists from both Taiwan and Seattle, including Ye Mimi, Scott Keva James, Jane Kaplan and Vanessa DeWolf, and how her vision evolved over many iterations. The roles of community, audience, and creative friendships are also explored in the context of how they can invigorate a creative work.
The Use of Therapeutic Music Training to Remediate Cognitive Impairment Following an Acquired Brain Injury: The Theoretical Basis and a Case Study
Authors: Jones Cheryl
Published: September 2020

Cognitive impairment is the most common sequelae following an acquired brain injury (ABI) and can have profound impact on the life and rehabilitation potential for the individual. The literature demonstrates that music training results in a musician’s increased cognitive control, attention, and executive functioning when compared to non-musicians. Therapeutic Music Training (TMT) is a music therapy model which uses the learning to play an instrument, specifically the piano, to engage and place demands on cognitive networks in order to remediate and improve these processes following an acquired brain injury. The underlying theory for the efficacy of TMT as a cognitive rehabilitation intervention is grounded in the literature of cognition, neuroplasticity, and of the increased attention and cognitive control of musicians. This single-subject case study is an investigation into the potential cognitive benefit of TMT and can be used to inform a future more rigorous study. The participant was an adult male diagnosed with cognitive impairment as a result of a severe brain injury following an automobile accident. Pre- and post-tests used standardized neuropsychological measures of attention: Trail Making A and B, Digit Symbol, and the Brown– Peterson Task. The treatment period was twelve months. The results of Trail Making Test reveal improved attention with a large decrease in test time on both Trail Making A (−26.88 s) and Trail Making B (−20.33 s) when compared to normative data on Trail Making A (−0.96 s) and Trail Making B (−3.86 s). Digit Symbol results did not reveal any gains and indicated a reduction (−2) in free recall of symbols. The results of the Brown–Peterson Task reveal improved attention with large increases in the correct number of responses in the 18-s delay (+6) and the 36-s delay (+7) when compared with normative data for the 18-s delay (+0.44) and the 36-s delay (−0.1). There is sparse literature regarding music based cognitive rehabilitation and a gap in the literature between experimental research and clinical work. The purpose of this paper is to present the theory for Therapeutic Music Training (TMT) and to provide a pilot case study investigating the potential efficacy of TMT to remediate cognitive impairment following an ABI.
Polycycl. Aromatic Hydrocarbon Exposure of Children in Typical Household Coal Combustion Environments: Seasonal Variations, Sources, and Carcinogenic Risks
Authors: Liu Yunwei , Qin Ning , Liang Weigang , Chen Xing , Hou Rong , Kang Yijin , Guo Qian , Cao Suzhen , Duan Xiaoli
Published: September 2020

Polycyclic aromatic hydrocarbon (PAH) emissions from the combustion of household solid coal for cooking and heating cause great harm to public health in China, especially in less developed areas. Children are one of the most susceptible population groups at risk of indoor air pollutants due to their immature respiratory and immune systems. However, information on PAH exposure of children is limited due to limited monitoring data. In this study, we aimed to assess the seasonal differences of PAHs in classrooms, analyze the pollutant sources, and calculate the incremental lifetime cancer risk attributable to PAHs in Shanxi Provence. A typical school using household coal combustion in Shanxi Province was selected. Fine particulate matter (PM2.5)samples were collected by both individual samplers and fixed middle-flow samplers during the heating and non-heating seasons in December 2018 and April 2019. The PAH concentrations in PM2.5 samples were analyzed by a gas chromatograph coupled to a mass spectrometer. The results showed that PAH concentrations in PM2.5 varied between 89.1 ng/m3 in the heating season and 1.75 ng/m3 in the non-heating season. The mean concentrations of benzo[a]pyrene (BaP), a carcinogenic marker of PAHs, were 10.3 and 0.05 ng/m3 in the heating and non-heating seasons, respectively. Source allocation analysis of individual portable and passive samplers revealed that the main contributors during heating and non-heating seasons were coal combustion and gasoline sources, respectively. According to the results of a Monte Carlo simulation, the incremental lifetime cancer risk values from the inhalation of PAHs in the heating and non-heating seasons were 3.1 × 10−6 and 5.7 × 10−8, respectively. The significant increase in PAHs and the incremental lifetime cancer risk in the heating season indicates that children are more exposed to health threats in winter. Further PAH exposure control strategies, including reducing coal usage and promoting clean fuel applications, need to be developed to reduce the risk of PAH-induced cancer.
A Universal Physics-Based Model Describing COVID-19 Dynamics in Europe
Authors: Contoyiannis Yiannis , Stavrinides Stavros G. , P. Hanias Michael , Kampitakis Myron , Papadopoulos Pericles , Picos Rodrigo , M. Potirakis Stelios
Published: September 2020

The self-organizing mechanism is a universal approach that is widely followed in nature. In this work, a novel self-organizing model describing diffusion over a lattice is introduced. Simulation results for the model’s active lattice sites demonstrate an evolution curve that is very close to those describing the evolution of infected European populations by COVID-19. The model was further examined against real data regarding the COVID-19 epidemic for seven European countries (with a total population of 290 million) during the periods in which social distancing measures were imposed, namely Italy and Spain, which had an enormous spread of the disease; the successful case of Greece; and four central European countries: France, Belgium, Germany and the Netherlands. The value of the proposed model lies in its simplicity and in the fact that it is based on a universal natural mechanism, which through the presentation of an equivalent dynamical system apparently documents and provides a better understanding of the dynamical process behind viral epidemic spreads in general—even pandemics, such as in the case of COVID-19—further allowing us to come closer to controlling such situations. Finally, this model allowed the study of dynamical characteristics such as the memory effect, through the autocorrelation function, in the studied epidemiological dynamical systems.
Increased Medical Visits and Mortality among Adults with Cardiovascular Diseases in Severely Affected Areas after Typhoon Morakot
Authors: Shih Hsin-I , Chao Tzu-Yuan , Huang Yi-Ting , Tu Yi-Fang , Sung Tzu-Ching , Wang Jung-Der , Chang Chia-Ming
Published: September 2020

Natural disasters have negative health impacts on chronic diseases in affected populations. Severely affected areas are usually rural areas with limited basic infrastructure and a population have that has limited access to optimal healthcare after a disaster. Patients with cardiovascular diseases are required to maintain quality care, especially after disasters. A population-based case-control study enrolled adults from the National Health Insurance Registry who had ischemic heart disease and cerebrovascular disease histories and lived in the area affected by Typhoon Morakot in 2009. Monthly medical visits for acute cerebrovascular and ischemic heart diseases markedly increased at approximately 1–2 months after the typhoon. Survival analysis during the two years following the typhoon indicated a significant increase in mortality in adults with an acute ischemic heart disease history who lived in the severely affected area. Mortality hazard analysis showed that among affected adults with previous cerebrovascular diseases and acute ischemic heart diseases, patients with diabetes (adjusted hazard ratio [HR]: 1.3–1.7), Chronic Kidney Disease (CKD) (adjusted HR: 2.0–2.7), chronic obstructive pulmonary diseases (COPD) and asthma (adjusted HR: 1.7–2.1), liver cirrhosis (adjusted HR: 2.3–3.3) and neoplasms (adjusted HR: 1.1–2.1) had significantly increased mortality rates. Consequently, high-quality and accessible primary healthcare plans should be made available to maintain and support affected populations after disasters.
STS: Spatial–Temporal–Semantic Personalized Location Recommendation
Authors: Li Wenchao , Liu Xin , Yan Chenggang , Ding Guiguang , Sun Yaoqi , Zhang Jiyong
Published: September 2020

The rapidly growing location-based social network (LBSN) has become a promising platform for studying users’ mobility patterns. Many online applications can be built based on such studies, among which, recommending locations is of particular interest. Previous studies have shown the importance of spatial and temporal influences on location recommendation; however, most existing approaches build a universal spatial–temporal model for all users despite the fact that users always demonstrate heterogeneous check-in behavior patterns. In order to realize truly personalized location recommendations, we propose a Gaussian process based model for each user to systematically and non-linearly combine temporal and spatial information to predict the user’s displacement from their currently checked-in location to the next one. The locations whose distances to the user’s current checked-in location are the closest to the predicted displacement are recommended. We also propose an enhancement to take into account category information of locations for semantic-aware recommendation. A unified recommendation framework called spatial–temporal–semantic (STS) is introduced to combine displacement prediction and the semantic-aware enhancement to provide final top-N recommendation. Extensive experiments over real datasets show that the proposed STS framework significantly outperforms the state-of-the-art location recommendation models in terms of precision and mean reciprocal rank (MRR).
Ponatinib and other CML Tyrosine Kinase Inhibitors in Thrombosis
Authors: Zeng Peng , Schmaier Alvin
Published: September 2020

Abl1 kinase has important biological roles. The Bcr-Abl1 fusion protein creates undesired kinase activity and is pathogenic in 95% of chronic myeloid leukemia (CML) and 30% of acute lymphoblastic leukemia (ALL) patients. Targeted therapies to these diseases are tyrosine kinase inhibitors. The extent of a tyrosine kinase inhibitor’s targets determines the degree of biologic effects of the agent that may influence the well-being of the patient. This fact is especially true with tyrosine kinase inhibitor effects on the cardiovascular system. Thirty-one percent of ponatinib-treated patients, the tyrosine kinase inhibitor with the broadest inhibitory spectrum, have thrombosis associated with its use. Recent experimental investigations have indicated the mechanisms of ponatinib-associated thrombosis. Further, an antidote to ponatinib is in development by re-purposing an FDA-approved medication.
The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition
Authors: Pucci Michela , Gomes Ferreira Inês , Malagolini Nadia , Ferracin Manuela , Dall’Olio Fabio
Published: September 2020

Background: The Sda antigen and its biosynthetic enzyme B4GALNT2 are highly expressed in healthy colon but undergo a variable down-regulation in colon cancer. The biosynthesis of the malignancy-associated sialyl Lewis x (sLex) antigen in normal and cancerous colon is mediated by fucosyltransferase 6 (FUT6) and is mutually exclusive from that of Sda. It is thought that the reduced malignancy associated with high B4GALNT2 was due to sLex inhibition. Methods: We transfected the cell lines SW480 and SW620, derived respectively from a primary tumor and a metastasis of the same patient, with the cDNAs of FUT6 or B4GALNT2, generating cell variants expressing either the sLex or the Sda antigens. Transfectants were analyzed for growth in poor adherence, wound healing, stemness and gene expression profile. Results: B4GALNT2/Sda expression down-regulated all malignancy-associated phenotypes in SW620 but only those associated with stemness in SW480. FUT6/sLex enhanced some malignancy-associated phenotypes in SW620, but had little effect in SW480. The impact on the transcriptome was stronger for FUT6 than for B4GALNT2 and only partially overlapping between SW480 and SW620. Conclusions: B4GALNT2/Sda inhibits the stemness-associated malignant phenotype, independently of sLex inhibition. The impact of glycosyltransferases on the phenotype and the transcriptome is highly cell-line specific.
Cost Overruns in Tunnelling Projects: Investigating the Impact of Geological and Geotechnical Uncertainty Using Case Studies
Authors: Paraskevopoulou Chrysothemis , Boutsis Georgios
Published: September 2020

Tunnelling projects seldom meet the initial budget requirements. Commonly, these types of projects suffer from cost overruns, which subsequently lead to project delivery delays mainly due to unsuccessful ground investigation as specified in the literature. The presented work scrutinises the effect of ground investigation in cost overruns. More specifically, various cost figures (total cost, construction cost, tunnel cost) are analysed for two case studies i) the Channel tunnel in the UK and ii) the Olmos Tunnel in Peru. Clayton’s relation between ground investigation and the construction cost is utilised and further investigated. In the Channel tunnel, the main problems faced led to a cost overrun of 78% for the total cost, 66% for the construction cost and 77% for the tunnelling cost. In the Olmos tunnel, two main geological scenarios are analysed and the construction cost overrun is calculated at 9.6% and 6.7%. Drawing on the conclusions, this research work proves that ground investigation can be one of the major factors influencing the tunnel cost.
Changed Profile of Serum Transferrin Isoforms in Primary Biliary Cholangitis
Authors: Grytczuk Agnieszka , Bauer Alicja , Gruszewska Ewa , Cylwik Bogdan , Chrostek Lech
Published: September 2020

Liver damage affects the synthesis of proteins and glycoproteins, and alters their posttranslational modification, such as glycosylation changing the serum profile of glycoprotein isoforms. The retention of hydrophobic bile acids in the course of cholestatic liver diseases is a major cause of liver damage in primary biliary cholangitis (PBC). The study objective was to determine the serum profile of transferrin isoforms in primary biliary cholangitis and compare it to transferrin isoforms profile in extrahepatic cholestasis. The study was carried out in 76 patients with PBC and 40 healthy blood donors. Transferrin isoforms were analyzed by the capillary electrophoresis method. The mean relative concentrations of disialotransferrin and trisialotransferrin in PBC were significantly lower than those in the healthy subjects (p < 0.001, p = 0.011; respectively). None of the transferrin isoforms changed according to the disease severity evaluated by the Ludwig scoring system. However, the disease stage affected the activity of alkaline phosphatase (ALP) and γ-glutamyl transferase (GGT), and albumin level (p = 0.002; p = 0.013 and p = 0.005, respectively). Our results indicate that serum profile of transferrin isoforms alters primary biliary cholangitis and differs in comparison to transferrin isoforms profile in extrahepatic cholestasis. The decreased concentrations of lower sialylated isoforms of transferrin (low percentage share in total transferrin level) are not associated with the histological stage of disease.