bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract 27 — Prevalence and Management Approach of Latent Tuberculosis Infection in Rheumatology Patients
Authors: Al Nokhatha Shamma Ahmad , AlKindi Fatima , Alfalasi Maryam , Abdelsalhen Merna , AlKhyeli Fatima , Alsaber Ahmad R.
Published: November 2023

Prior to immunosuppression, rheumatology patients are routinely screened for latent tuberculosis infection (LTBI) using Interferon-Gamma Release Assays (IGRA). The management of latent and indeterminate IGRA results varied among institutions and long-term outcome data is lacking. We conducted a retrospective study at Tawam Hospital, United Arab Emirates, to examine the frequency and management of positive and indeterminate IGRA results and tuberculosis infection in rheumatic patients.

Methods

Laboratory records and hospital electronic medical system were used to obtain information about IGRA results over a 12 years period (April 2010-April 2022).

Results

In our hospital record over a 12-year period, we found a total of 1012 positive and 223 indeterminate IGRA test results. Within the rheumatology department, 123 positive and 39 indeterminate IGRA results were identified. In the indeterminate IGRA group, the majority were female (n=24, 61.5%), UAE nationals (n=22, 56.4%), and had a mean age of 38.6 years. Systemic lupus erythematosus (SLE) was the most prevalent rheumatologic condition (n=21, 53.8%). 33.3% (n=13) were on disease modifying anti-rheumatic drugs (DMARDs) and 66.7% (n=26) were on corticosteroid during IGRA testing. A total of 8 patients (20.5%) received anti-TB medications. In a positive IGRA group, the mean age of 55.7 years and a female-to-male ratio of 3:1. The most common rheumatologic conditions were RA (n=67, 54.4%). Approximately 52.8% (n=65) of patients were on conventional DMARDs, 66.7% (n=26) were on corticosteroids during IGRA testing, and 60% (n=74) received anti-TB medications. Two cases (1.6%) of active TB infections were detected among patients with positive IGRA tests, both of whom were receiving anti-TNFa inhibitor treatment in combination with methotrexate. No cases of active TB infection were observed in the indeterminate IGRA group.

Conclusion

Tuberculosis risk in positive and indeterminate IGRA results for rheumatological conditions is low. Further multicenter studies are required to analyze patient outcomes and differences in TB-endemic and non-endemic regions.
Routing in Multimodal Transportation Networks with Non-scheduled Lines
Authors: Drakulic Darko , Loiodice Christelle , Lehoux Vassilissa
Published: November 2023

Over the last decades, new mobility offers have emerged to enlarge the coverage and the accessibility of public transportation systems. In many areas, public transit now incorporates on-demand transport lines, that can be activated at user need. In this paper, we propose to integrate lines without predefined schedules but with predefined stop sequences into a state-of-the-art trip planning algorithm for public transit, the Trip-Based Public Transit Routing algorithm [
33
]. We extend this algorithm to non-scheduled lines and explain how to model other modes of transportation, such as bike sharing, with this approach. The resulting algorithm is exact and optimizes two criteria: the earliest arrival time and the minimal number of transfers. Experiments on two large datasets show the interest of the proposed method over a baseline modelling.
Subtle Sound Design: Designing for Experience Blend in a Historic House Museum
Authors: Yates Mia F. , Løvlie Anders S.
Published: November 2023

In this article, we present and discuss a user-study prototype, developed for the Bakkehuset historic house museum in Copenhagen. We examine how the prototype—a digital sound installation—can expand visitors’ experiences of the house and offer encounters with immaterial cultural heritage. Historic house museums often hold back on utilizing digital communication tools inside the houses, since a central purpose of this type of museum is to preserve an original environment. Digital communication tools, however, hold great potential for facilitating rich encounters with cultural heritage and in particular with the immaterial aspects of museum collections and their histories. In this article, we present our design steps and choices, aiming at subtly and seamlessly adding a digital dimension to a historic house. Based on qualitative interviews, we evaluate how the sound installation at Bakkehuset is sensed, interpreted, and used by visitors as part of their museum experience. In turn, we shed light on the historic house museum as a distinct design context for designing hybrid visitor experiences and point to the potentials of digital communication tools in this context.
A Privacy Preserving System for Movie Recommendations Using Federated Learning
Authors: Neumann David , Lutz Andreas , Müller Karsten , Samek Wojciech
Published: November 2023

Recommender systems have become ubiquitous in the past years. They solve the
tyranny of choice
problem faced by many users, and are utilized by many online businesses to drive engagement and sales. Besides other criticisms, like creating filter bubbles within social networks, recommender systems are often reproved for collecting considerable amounts of personal data. However, to personalize recommendations, personal information is fundamentally required. A recent distributed learning scheme called federated learning has made it possible to learn from personal user data without its central collection. Consequently, we present a recommender system for movie recommendations, which provides privacy and thus trustworthiness on multiple levels: First and foremost, it is trained using federated learning and thus, by its very nature, privacy-preserving, while still enabling users to benefit from global insights. Furthermore, a novel federated learning scheme, called FedQ, is employed, which not only addresses the problem of non-i.i.d.-ness and small local datasets, but also prevents input data reconstruction attacks by aggregating client updates early. Finally, to reduce the communication overhead, compression is applied, which significantly compresses the exchanged neural network parametrizations to a fraction of their original size. We conjecture that this may also improve data privacy through its lossy quantization stage.
Guidelines on the use of sex and gender in cardiovascular research
Authors: Usselman Charlotte W. , Lindsey Merry L. , Robinson Austin T. , Habecker Beth A. , Taylor Chloe E. , Merryman W. David , Kimmerly Derek , Bender Jeffrey R. , Regensteiner Judith G. , Moreau Kerrie L. , Pilote Louise , Wenner Megan M. , O’Brien Myles , Yarovinsky Timur O. , Stachenfeld Nina S. , Charkoudian Nisha , Denfeld Quin E. , Moreira-Bouchard Jesse D. , Pyle W. Glen , DeLeon-Pennell Kristine Y.
Published: November 2023

In cardiovascular research, sex and gender have not typically been considered in research design and reporting until recently. This has resulted in clinical research findings from which not only all women, but also gender-diverse individuals have been excluded. The resulting dearth of data has led to a lack of sex- and gender-specific clinical guidelines and raises serious questions about evidence-based care. Basic research has also excluded considerations of sex. Including sex and/or gender as research variables not only has the potential to improve the health of society overall now, but it also provides a foundation of knowledge on which to build future advances. The goal of this guidelines article is to provide advice on best practices to include sex and gender considerations in study design, as well as data collection, analysis, and interpretation to optimally establish rigor and reproducibility needed to inform clinical decision-making and improve outcomes. In cardiovascular physiology, incorporating sex and gender is a necessary component when optimally designing and executing research plans. The guidelines serve as the first guidance on how to include sex and gender in cardiovascular research. We provide here a beginning path toward achieving this goal and improve the ability of the research community to interpret results through a sex and gender lens to enable comparison across studies and laboratories, resulting in better health for all.
Neuraminidase-induced externalization of phosphatidylserine activates ADAM17 and impairs insulin signaling in endothelial cells
Authors: Ferreira-Santos Larissa , Ramirez-Perez Francisco I. , Foote Christopher A. , Augenreich Marc A. , McMillan Neil J. , Williams Morgan B. , Gonzalez-Vallejo Juan D. , Power Gavin , Wheeler Andrew A. , Manrique-Acevedo Camila , Martinez-Lemus Luis A. , Padilla Jaume
Published: November 2023

This work provides the first evidence that neuraminidase, an enzyme increased in the circulation of men and women with type 2 diabetes (T2D), promotes anoctamin-6 (ANO6)-dependent externalization of phosphatidylserine in endothelial cells, which in turn leads to activation of a disintegrin and metalloproteinase-17 (ADAM17) and consequent shedding of the insulin receptor-α from the cell surface. Hence, this work supports that consideration should be given to the neuraminidase-ANO6-ADAM17 axis as a novel potential target for restoring endothelial insulin sensitivity in T2D.
Characteristics of Self-Rated Oral Health among Syrian Refugee Parents in Ontario
Authors: Alzaghoul Aseel , Rahimpoor-Marnani Parmin , Yunis Khalid , Alamgir Akm , Alghalyini Baraa , Tamim Hala
Published: November 2023

Background. Canada has been hosting Syrian refugees since early 2015. Almost half of the Syrian refugee population lives in Ontario, with dental health being at the top of the list of important immediate needs. The objective of the study was to evaluate self-rated oral health and its associated factors among Syrian refugee parents residing in Ontario. Methods. This was a cross-sectional study where 540 Syrian refugee parents, residing in Ontario and with at least one child less than 18 years of age, were interviewed. Information about self-rated oral health was collected based on the question “In general, how would you rate the health of your teeth and mouth?” with answers ranging from 1 representing “excellent” and 5 representing “very poor.” Multiple linear regression analysis was performed to assess the independent relationship between each of the sociodemographic-, migration-, health-, dental-related factors, and self-rated oral health. Results. The overall prevalence of poor and very poor self-rated oral health was 43.5%. The results showed that the presence of dental health insurance, private sponsorship, improved physical and mental health, and regular visits to the dentist were factors related to improved oral health. Discussion. To achieve better oral health outcomes among refugee populations, including Syrian refugees, efforts should be focused on improving dental care and dental insurance for vulnerable populations.
Design of a Three-Dimensional Uniform UHF Near-Field RFID Reader Antenna
Authors: Yao Yuan , Xue Yani , Ren Xiaojuan , Yu Junsheng , Cheng Xiaohe , Chen Xiaodong
Published: November 2023

This paper proposes a three-dimensional uniform ultra-high frequency (UHF) near-field radio frequency identification (RFID) reader antenna. The antenna achieves a uniform electric field in the x and y directions by placing a single branch microstrip line along the x-axis and y-axis directions, respectively. It reaches a uniform electric field in the z-direction by a centrosymmetric four-branch microstrip line. The proposed antenna achieves three-dimensional direction uniformity through a reconfigurable method. The impedance matching bandwidth range of

S

11

<−10 dB for simulation and measurement includes 0.66 to 0.98 GHz, which can meet the near-field RFID operation frequency band demand. The isolation degrees between ports are less than −24.6 dB within the UHF RFID frequency band (0.86 to 0.96 GHz). In addition, the antenna also has the characteristic of low gain in the far field, and the maximum gain in the far field is less than −27 dBi when operating at different ports. The test results show that the proposed antenna three-dimensional uniform volume of dipole tags above the antenna is 99 mm × 99 mm × 20 mm, and the reading volume of the near-field tags is 40 mm × 40 mm × 5 mm. When the tags are placed on a book, there will be a slight variation in the reading range of the tags.
Acceptance Factors and Psychological Investigation of Clinical Trials in Cancer Patients
Authors: Sun Jiangjie , Fang Jingyi , Zhang Chenchen , Jia Nannan , Zhao Weiming , Gao Jinjian , Huang Yingying , Hao Jiqing , Zhang Liping
Published: November 2023

Aim. To understand the degree of oncology patients’ awareness of drug clinical trials and oncology patients’ willingness to participate in drug clinical trials and the factors influencing them. Methods. The differences in the relevant variables of patients’ willingness to accept clinical trials were analyzed, and a descriptive analysis was done for the measurement data (mean and standard deviation). Pearson’s correlation coefficient analysis was used to examine the correlation between willingness and the demographic variables. Stepwise regression analysis was used to explore the influencing factors of patients’ willingness to accept clinical trials. Results. There were no statistical differences in age, gender, education level, marital status, place of residence, monthly income, medical payment method, and treatment time (

P
>
0.05

). Patients’ willingness to accept drug clinical trials differed in their cognitive degree of clinical drug trials (

P
=
0.002

). Patients’ willingness to accept drug clinical trials differed in their experience in clinical trials (

P
<
0.001

). The correlation difference was statistically significant. The willingness to accept drug clinical trials was negatively correlated with treatment time (

R
=
−
0.16

,

P
<
0.05

) and positively correlated with awareness of clinical trials and whether they had been subjects (

R
=
0.16

and 0.43,

P
<
0.05

). Multiple regression analysis showed that patients’ willingness was directly influenced by age, treatment time, and whether they had been subjects (

F
=
21.315

,

P
<
0.001

). Conclusion. Age, treatment time, and whether they had been subjects were the direct influencing factors of patients’ willingness. This study pointed out that hospitals should do a good job in the publicity of clinical trials of new drugs, expand publicity channels, increase publicity efforts, improve the awareness of clinical trials of the masses, and promote the enthusiasm of the masses to participate in clinical trials of drugs.
Death Anxiety and Its Related Factors among Advanced Nurse Practitioner Candidates: A Cross-Sectional Study
Authors: Long Nguyen Hoang , Thanasilp Sureeporn , Anh Truong Tuan , Minh Chinh Nguyen Thi
Published: November 2023

Aim. To examine death anxiety and its related factors among candidates to become advanced nurse practitioners. Background. Nurses are required to care for dying patients and frequently face death-related issues in clinical practice. Yet, as human beings, it is natural for nurses to feel anxious about their own mortality, which can be incited by witnessing the death of another person. It is evident that a nurse’s death anxiety level may influence how they care for their patients. However, studies to date focus primarily on the death anxiety of patients. Little is known about such experiences among registered nurses, especially those training to be advanced nurse practitioners. Design. This is a quantitative cross-sectional study. Methods. Participants were postgraduate students pursuing their advanced nurse practitioner degree at Nam Dinh University of Nursing, Vietnam. The enrolment criteria included full-time student status and a willingness to participate in the study. Data were collected from 297 participants who completed a self-administered questionnaire during February or March 2022. Death anxiety was measured using Templer’s Death Anxiety Scale. Results. Most advanced nurse practitioner candidates demonstrated a moderate level of death anxiety (109/297; 39.1%). Nearly three in ten (74/297; 26.5%) reported a high level of death anxiety. No statistically significant associations between nurses’ life satisfaction, age, and death anxiety were found. Death anxiety levels did not differ by gender, work position, workplace, or frequency of caring for dying patients (

p
>
0.05

). Conclusions. There is an identified need to support nurses, especially future nurse clinical leaders, to manage their death anxiety. Professional training programs should offer nurses the opportunity to develop skills necessary to cope with their negative attitude toward death. Further research is recommended to confirm the apparent associations between death anxiety and demographic and psychosocial factors. Those relationships should be examined with appropriate consideration of the contextual and cultural environment in which the study is performed.
“We Were Already in Lockdown”: Exploring the Impact of the COVID-19 Pandemic on Asylum Seekers and Refugees in Australia—Mental Health, Social Isolation, Abandonment, and Financial Precarity
Authors: Trew Sebastian , Couch Jen , Cox Jillian , Cinque Vivien
Published: November 2023

The aim of this study was to give a voice to people from asylum seeker and refugee backgrounds in Australia during the COVID-19 pandemic and to explore their perspectives concerning their experiences of everyday life. The findings highlight the impacts the pandemic had on these groups, how it exacerbated existing vulnerabilities, worsened mental health, increased social isolation, affirmed a sense of abandonment, and heightened financial precarity. The study adhered to a social constructivist approach. It used a qualitative methodology guided by a narrative research approach. Semistructured in-depth interviews with thirteen participants were thematically analyzed to generate a global theme and subthemes. For people from asylum seeker and refugee backgrounds in Australia, the government-mandated lockdown measures led to increased feelings of loneliness and loss of social support networks, reduced access to public spaces, and limited engagement in face-to-face activities and opportunities for socializing and maintaining mental well-being. The pandemic intensified domestic partner violence incidents and financial stress emerged as a major concern. Participants lost or had reduced employment, and many were ineligible for government financial support. These challenges intersected with preexisting hardships which contributed to feelings of abandonment. Based on the findings, implications include the need for inclusive policies and targeted healthcare support, measures to prevent and respond to partner violence, and inclusive financial assistance schemes that address the unique needs of people from asylum seeker and refugee backgrounds in Australia. Further research is needed to inform therapeutic supports and trauma-informed services for these groups.
Chemical Application of Topological Indices in Infertility Treatment Drugs and QSPR Analysis
Authors: Sultana Sobia
Published: November 2023

The main challenges faced by medical researchers while producing novel drugs are time commitment, amplified costs, creating a safety profile for the medications, reduced solubility, and a lack of experimental data. Chemical graph theory makes an important theoretical contribution to drug development and design by investigating the structural properties of molecules. To improve drug research and assess the effectiveness of treatments, topological indices aim to provide a mathematical representation of molecular structures. In this study, the author examined a number of recently used drugs, including tamoxifen, mesterolone, anastrozole, and letrozole which are used to treat infertility. We compute the topological descriptors with the limiting behaviors associated with these pharmaceutical drugs and offer degree-based topological parameters for them. We conducted a QSPR investigation on the prospective degree-based topological descriptors using quadratic, cubic, exponential, and logarithmic regression models.
Multiple Disturbances of Existing Tunnels Caused by Deep Excavation and New Shield Tunnel
Authors: Li Haoran , Ye Fei , Su Enjie , Han Xingbo
Published: November 2023

With the continuous development of urban underground spaces, new underground engineering approaches are becoming more similar to existing operating tunnels. Existing research is typically concerned with the impact of a single project, such as a new tunnel or deep excavation, on existing shield tunnels. There are few studies on the influence of both excavation and overcrossing tunneling on operational tunnels. Taking a section ranging from the Chengzhan Station to the Jiangcheng Road Station of Hangzhou Metro Line 7 as a case study, this study analyzes the automatic monitoring data of the existing tunnel within this section. Through data analysis, the influences of deep excavation and shield tunneling on the vertical settlement, horizontal displacement, segment convergence, and differential settlement of the tunnel ballast of the adjacent existing line segment are assessed. The influence of deep excavation and overcrossing tunneling on multiple disturbances of existing line tunnels is summarized. This study will be useful for similar projects involving deep excavation next to existing tunnels and overcrossing tunneling, as it will help clarify the protection range of existing lines and determine the displacement alarm value of existing structures.
Genome‐Wide Identification and Characterization of Major RNAi Genes Highlighting Their Associated Factors in Cowpea (Vigna unguiculata (L.) Walp.)
Authors: Hasan Mohammad Nazmol , Mosharaf Md Parvez , Uddin Khandoker Saif , Das Keya Rani , Sultana Nasrin , Noorunnahar Mst. , Naim Darun , Mollah Md. Nurul Haque
Published: November 2023

In different regions of the world, cowpea (Vigna unguiculata (L.) Walp.) is an important vegetable and an excellent source of protein. It lessens the malnutrition of the underprivileged in developing nations and has some positive effects on health, such as a reduction in the prevalence of cancer and cardiovascular disease. However, occasionally, certain biotic and abiotic stresses caused a sharp fall in cowpea yield. Major RNA interference (RNAi) genes like Dicer‐like (DCL), Argonaute (AGO), and RNA‐dependent RNA polymerase (RDR) are essential for the synthesis of their associated factors like domain, small RNAs (sRNAs), transcription factors, micro‐RNAs, and cis-acting factors that shield plants from biotic and abiotic stresses. In this study, applying BLASTP search and phylogenetic tree analysis with reference to the Arabidopsis RNAi (AtRNAi) genes, we discovered 28 VuRNAi genes, including 7 VuDCL, 14 VuAGO, and 7 VuRDR genes in cowpea. We looked at the domains, motifs, gene structures, chromosomal locations, subcellular locations, gene ontology (GO) terms, and regulatory factors (transcription factors, micro‐RNAs, and cis‐acting elements (CAEs)) to characterize the VuRNAi genes and proteins in cowpea in response to stresses. Predicted VuDCL1, VuDCL2(a, b), VuAGO7, VuAGO10, and VuRDR6 genes might have an impact on cowpea growth, development of the vegetative and flowering stages, and antiviral defense. The VuRNAi gene regulatory features miR395 and miR396 might contribute to grain quality improvement, immunity boosting, and pathogen infection resistance under salinity and drought conditions. Predicted CAEs from the VuRNAi genes might play a role in plant growth and development, improving grain quality and production and protecting plants from biotic and abiotic stresses. Therefore, our study provides crucial information about the functional roles of VuRNAi genes and their associated components, which would aid in the development of future cowpeas that are more resilient to biotic and abiotic stress. The manuscript is available as a preprint at this link: doi:10.1101/2023.02.15.528631v1.
Parental Involvement in the Transition from Paediatric to Adult Care for Youth with Chronic Illness: A Scoping Review of the North American Literature
Authors: Badour Bryn , Bull Amanda , Gupta Abha A. , Mirza Raza M. , Klinger Christopher A.
Published: November 2023

With medical advancements and improvements in medical technology, an increasing number of children with chronic conditions survive into adulthood. There is accordant growing interest toward supporting adolescents throughout the transition from paediatric to adult care. However, there is currently a paucity of research focusing on the role that these patients’ parents should play during and after the transition to adult care and if maintained parental involvement is beneficial during this transition within a North American context. Accordingly, this scoping review utilized Arksey and O’Malley’s five-step framework to consider parental roles during chronically ill children’s transition to adult care. APA PsycInfo, CINAHL, EMBASE, MEDLINE, ProQuest, and Scopus were searched alongside advanced Google searches. Thematic content analysis was conducted on 30 articles meeting the following inclusion criteria: (1) published in English between 2010 and 2022, (2) conducted in Canada or the United States, (3) considered adolescents with chronic conditions transitioning to adult care, (4) family being noted in the title or abstract, and (5) patient populations of study not being defined by delays in cognitive development, nor mental illness. Three themes emerged from the literature: the impacts of maintaining parental involvement during transition to adult care for patients, parents experiencing feeling loss of stability and support surrounding the transition of their child’s care, and significant nonmedical life events occurring for youths at the time of transition of care. Parents assuming supportive roles which change alongside their maturing child’s needs were reported as being beneficial to young peoples’ transition processes, while parents who hover over or micromanage their children during this time were found to hinder successful transitions. Ultimately, the majority of reviewed articles emphasized maintained parental involvement as having a net positive impact on adolescents’ transitions to adult care. As such, practice and policies should be structured to engage parents throughout the transition process to best support their chronically ill children during this time of change.
Supplementary Data 2 from Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma
Authors: Choo Zhang'E , Koh Xiaoying , Wong Megan Rui En , Ashokan Ruth Minothini , Ali Ahamed Nurul Suhana Binte , Kang CongBao , Kuick Chik Hong , Chang Kenneth Tou En , Larisch Sarit , Loh Amos Hong Pheng , Chen Zhi Xiong
Published: November 2023

Supplementary Data to Fig 4A
Figure S3 from Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma
Authors: Choo Zhang'E , Koh Xiaoying , Wong Megan Rui En , Ashokan Ruth Minothini , Ali Ahamed Nurul Suhana Binte , Kang CongBao , Kuick Chik Hong , Chang Kenneth Tou En , Larisch Sarit , Loh Amos Hong Pheng , Chen Zhi Xiong
Published: November 2023

Supplementary Figure S3, related to Figure 3. Generation of luciferase-tagged XIAP using CRISPR knock-in gene editing.
Supplementary Figure S6 from Activation of KrasG12D in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Authors: Chaudhary Priyanka , Xu Xia , Wang Guangfang , Hoj Jacob P. , Rampersad Rishi R. , Asselin-Labat Marie-Liesse , Ting Stephanie , Kim William , Tamayo Pablo , Pendergast Ann Marie , Onaitis Mark W.
Published: November 2023

RepSox treatment increases Sox2 levels while TGFb remains unchanged in KrasG12D mutant lungs
Entrectinib for NTRK Fusion-Positive Metastatic Melanoma Progressing on Combined PD-1 and CTLA-4 Inhibition: A Case Report
Authors: Dawood Shaheenah , Ali Zulfaqqar Jaffar
Published: November 2023

Introduction: The burden of melanoma is increasing globally. Despite the use of immunotherapy and targeted therapy, the prognosis of metastatic melanoma remains relatively poor. The integration of comprehensive molecular profiling can lead to the detection of actionable biomarkers and the expansion of treatment options, thereby prolonging cancer patient survival. Case Presentation: We herein present the case of a female 54-year-old patient diagnosed with melanoma of the right knee, for which she underwent surgery. Patient showed progression of disease after 10 cycles of adjuvant nivolumab. Ipilimumab (1 mg/kg every 3 weeks) was added to the treatment regimen but no clinical improvement was observed. Molecular profiling was conducted based on patient tissue, and an ANXA2-NTRK3 fusion was detected in the tumor. This specific fusion has not been previously reported; however, it is in-frame and similar to other known oncogenic NTRK fusions. At the time of entrectinib initiation, the patient had clear disease progression on the right leg on standard of care immunotherapy. She was commenced on entrectinib 200 mg once daily for 2 weeks. Dose escalation was attempted, and treatment intensity was managed based on drug tolerability. Good treatment response was observed on laboratory and radiologic parameters. As of September 2023, i.e., 2.5 years after treatment initiation, patient disease continues to be controlled with entrectinib. Conclusion: Profiling of advanced tumors is important to determine the presence of agnostic markers that can be targeted and ultimately improve the prognostic outcome of patients after the failure of standard of care.
Long-Term Clinical Outcomes of Optimizing Combination Therapy for Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Retrospective Study
Authors: Min Gi-June , Rhee Chin Kook , Kim Tong Yoon , Jeon Young-Woo , O Joo Hyun , Choi Byung-Ock , Park Gyeongsin , Cho Seok-Goo
Published: November 2023

Introduction: Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma progresses with advancing disease stage. However, no standard treatment approach has been established. This single-center retrospective study evaluated clinical and radiological characteristics, treatment modalities, and long-term prognosis of pulmonary MALT lymphoma. Methods: The study included 42 patients diagnosed with pulmonary MALT lymphoma between October 2004 and July 2019. Primary therapeutic modalities were determined using modified Ann Arbor staging. Therapeutic response was evaluated via computed tomography and laboratory analyses every 6 months for 5 years. Radiological findings were categorized based on the Lugano classification as complete response (CR), partial response, stable disease (SD), or progressive disease. Results: Initial treatment included observation (n = 2), surgical resection (n = 6), or systemic chemotherapy (n = 34). Patients treated surgically had localized disease and achieved initial and long-term CR. Of the 34 patients who underwent chemotherapy, 30 achieved CR, 2 achieved SD, and 2 died. Overall and progression-free survival (PFS) rates were 93.9% and 54.3%, respectively. Multivariate analysis indicated that PFS was lower in patients with modified Ann Arbor stage III-IV lymphoma and those who did not achieve CR. Conclusions: Optimized treatment based on anatomical location, pulmonary function, and disease stage can improve long-term survival in patients with pulmonary MALT lymphoma.
Exercise Regulates Myokines in Aging-Related Diseases through Muscle-Brain Crosstalk
Authors: Wang Bingqing , Liang Jiling , Lu Chen , Lu Aming , Wang Cenyi
Published: November 2023

Background: The related functions of skeletal muscle and brain decrease significantly with age, and muscle-brain-related diseases are primarily associated with each other. Exercise can promote the secretion of myokines in skeletal muscle, showing a beneficial effect on the function of both, reflecting muscle-brain crosstalk. However, the key mechanism of action of exercise-regulated myokines in muscle-brain diseases remains unclear. Summary: This review is intended to sort out and explore the key mechanism of the effect of exercise regulatory myokines on muscle-brain diseases through summarizing the relevant literature on the level of motor regulatory myokines in recent years and pay special attention to the impact of exercise type, intensity, and duration on myokine expression levels. Key Messages: The mechanism by which exercise regulates myokine levels in muscle-brain diseases is explained, and an effective exercise prescription for myokine expression that is more suitable for the elderly based on relevant literature is proposed. This work may hold certain value for subsequent exercise treatment of chronic diseases in the elderly and for further research on muscle-brain crosstalk.
ІСТОРІЯ КАФЕДРИ ІНФЕКЦІЙНИХ ХВОРОБ ХАРКІВСЬКОГО НАЦІОНАЛЬНОГО МЕДИЧНОГО УНІВЕРСИТЕТУ В ПОДІЯХ І ПЕРСОНАЛІЯХ. ПОГЛЯД КРІЗЬ СТОЛІТТЯ (1923-2023)
Authors: Капустник В. А. , Юрко К. В. , Козько В. М. , Меркулова Н. Ф. , Граділь Г. І. , Ткаченко В. Г. , Соломенник Г. О. , Могиленець О. І.
Published: November 2023

Висвітлено основні події та персоналії в історії кафедри інфекційних хвороб Харківського національного медичного університету за 100 років її існування.
УДОСКОНАЛЕННЯ РАННЬОЇ ЛАБОРАТОРНОЇ ДІАГНОСТИКИ ЛЕПТОСПІРОЗУ В УМОВАХ ВОЄННОГО СТАНУ
Authors: Нартов П. В. , Маслова В. С. , Кацапов Д. В. , Юрко К. В. , Лєсна А. С. , Якущенко В. А. , Кучерявченко В. В. , Джурмез М. Г. , Асоян І. М.
Published: November 2023

Проаналізовано ефективність методу мікроскопії у «темному полі» крові та сечі хворих з підозрою на лептоспіроз та охарактеризовано клініко-лабораторні зміни пацієнтів з підтвердженим діагнозом лепто­спірозу за допомогою цього методу. У ранньому періоді захворювання спіралеподібні бактерії виявлено у 10,7 % проб крові та дещо менше – 1,6 %, – в сечі, що у поєднанні з клініко-анамнестичними даними підвищує вірогідність встановлення діагнозу. У більшості хворих спостерігали безжовтяничну форму захворювання з переважанням у перший тиждень захворювання у 40,9 % хворих респіраторних симптомів із подальшим виявленням ураження нирок із болем у попереку у 50 %, та змінами у вигляді протеїнурії та еритроцитурії і відсутністю лейкоцитурії, що може бути однією з диференційно-діагностичних ознак порівняно із запальними захворюваннями нирок.
Посилення регенерації кістки щелеп у процесі ортодонтичного лікування хворих на генералізований пародонтит із переважанням симпатичної нервової системи
Authors: Батіг І. В. , Борисенко А. В.
Published: November 2023

Резюме. У комплексному лікуванні хворих на генералізований пародонтит все частіше використовують різноманітні методи ортодонтичного лікування. Проте ортодонтичне лікування необхідно доповнювати медикаментозною стимуляцією процесів остеорегенерації. При цьому варто враховувати стан вегетативної нервової системи пацієнта. Враховуючи це, були використані дані методики лікування, які доповнили препаратом, що посилює процеси мінералізації кісток, – «Кальцинова».

Мета дослідження – визначити ефективність застосування медикаментозного комплексу для стимуляції утворення альвеолярної кістки при ортодонтичному лікуванні хворих на генералізований пародонтит, у яких переважає діяльність симпатичного відділу вегетативної нервової системи.

Матеріали і методи. У даному дослідженні взяли участь 40 хворих на генералізований пародонтит молодого віку (18–35 років), у яких були виявлені зміщення фронтальних зубів верхньої щелепи. Пацієнтам провели ортодонтичне лікування. Для корекції стану вегетативної нервової системи в лікуванні генералізованого пародонтиту їм призначали комплекс медикаментозних засобів, доповнений препаратом «Кальцинова» для стимуляції остеогенезу. Всім пацієнтам було проведене комплексне обстеження пародонта з визначенням необхідних гігієнічних індексів для оцінки стану пародонта під час лікування.

Результати досліджень та їх обговорення. Проведене обстеження стану пародонта показало, що практично у всіх пацієнтів відмічали поліпшення стану порожнини рота. Встановлено певну динаміку патологічного процесу під впливом комплексного лікування. Аналіз отриманих результатів підтверджує необхідність проведення ортодонтичного лікування хворих на генералізований пародонтит із використанням методів корекції стану вегетативної нервової системи та стимуляцією остеогенезу. Показано, що їх застосування справляє сприятливий вплив на тканини пародонта і підвищує ефективність лікування генералізованого пародонтиту.

Висновки. Корекція функцій симпатичної вегетативної нервової системи підвищує ефективність медикаментозного лікування. Додаткове уведення до складу медикаментозної композиції препарату «Кальцинова» для стимуляції остеогенезу дозволить досягти більш стабільних результатів лікування хворих на генералізований пародонтит та зберегти наявний рівень втрати прикріплення.
ЗАРУБІЖНИЙ ДОСВІД ПІДГОТОВКИ МАГІСТРІВ ФАРМАЦІЇ З ПИТАНЬ СУПРОВОДУ НАСЕЛЕННЯ ІЗ ПОРУШЕННЯМИ ПСИХІЧНОГО ЗДОРОВʼЯ
Authors: Bilousova N. A. , Mykhalchuk V. M. , Protsiuk O. V. , Kabachna A. V.
Published: November 2023

Мета роботи. Провести порівняльний аналіз, узагальнення та встановити шляхи імплементації зарубіжного досвіду підготовки магістрів фармації з питань психічного здоровʼя в освітній процес із підготовки магістрів фармації України.

Матеріали і методи. Використано наукові публікації, міжнародні документи, сайти міжнародних організацій, співтовариств фармацевтів, офіційні сайти навчальних закладів, освітньо-професійні програми за спеціальністю 226 Фармація, промислова фармація. Використано методи систематизації, порівняльного аналізу та узагальнення.

Результати й обговорення. У статті проведено порівняльний аналіз освітньо-професійних програм підготовки магістрів фармації, систематизовано міжнародні документи та результати досліджень, в яких розкривається досвід впровадження найкращих практик із питань психічного здоровʼя в освітній процес підготовки фармацевтів на магістерському рівні за змістом, структурою навчальних програм, формою організації освітнього процесу.

Висновки. Результати дослідження свідчать, що практика професійної підготовки магістрів фармації з питань психічного здоров’я є досить поширеною на світовому рівні та представлена в різних наукових публікаціях, результати аналізу яких свідчать про різні форми організації навчання. Перспективним вбачаємо імплементацію кращих зарубіжних освітніх практик у професійну підготовку фармацевтів України з питань психічного здоровʼя на магістерському рівні з подальшою підготовкою у системі безперервного професійного розвитку; розширення протоколів фармацевтів із питань надання фармацевтичної допомоги у сфері реалізації ЛЗ, які відпускаються за рецептом лікаря за Програмою медичних гарантій.
Changes in insulin resistance after ileoduodenoplasty performing
Authors: PODPRYATOV S. E. , PODPRIATOV S. S. , IVANKO O. V. , KORCHAK V. P. , LEVYTSKA O. V. , SATSYUK I. V.
Published: November 2023

The aim of the work: to analyze own experience of IR changes in the course of performing metabolic correction in original way of ileac shift by stomach with duodenum exclusion from food passage.

Materials and Methods. Insulin resistance (IR) was studied in 15 patients with body mass index (BMI) within 20.3–58.3 kg/m2. Surgery consists of ileoduodenoplasty (IDP) performing by the way of duodenal and ileac transection and ileac shift by stomach with duodenum exclusion from food passage. In all patients fasting blood glucose, insulin and c-peptide levels were measured before surgery and 7–21 days by surgery.

According to blood level of insulin and c-peptide before surgery all cases may be differentiated into three groups.

Results and Discussion. Three weeks after surgery only in four patients of group 1 insulin content was on the upper level of norm or slightly higher of it while became, respectively, 59.1 %, and 32.8 %, and 42.2 %, and 34.7  % from preoperative indication. In two patients of group 2 insulin level falls into the range of norm, while in one it left slightly higher of those and, respectively, became 49.7 %, 34.7 %, and 21.0 % from those of pre-operation. Three patients (group 3) with insulin level withing normal range while c-peptide level was higher than range of norm.

It is not understandable at the time why c-peptide level at three weeks after surgery changes differently in all groups.

In all cases IR, which was regarded as higher than normal insulin or c-peptide level, disappear within three weeks after surgery.

Obtained data elucidate the difference in the IR origin. It is of interest the similar level of insulin in IR despite different concentration of c-peptide.

Also, it is of interest elevation of c-peptide level after surgery while IR disappear. Reasons of such reaction need further research.
Dynamics of changes in markers of endogenous intoxication in rats with simulating acute generalized peritonitis on a background of obesity
Authors: KLISHCH I. M. , MALEVYCH N. M. , NEBESNA Z. M.
Published: November 2023

The aim of the work: to study the state of indicators of endogenous intoxication in the body of experimental animals with simulated AGP on the background of obesity and to compare them with groups of animals with obesity and with animals with AGP.

Materials and Methods. The experiment used 64 white Wistar rats, which were divided into three groups: the main group – 24 animals with AGP modeling against the background of obesity; the comparison group – 8 animals with modeling of obesity only; another compa­rison group – 24 animals with only AGP simulation; the control group consisted of 8 intact animals kept in standard vivarium conditions. АPP was modeled by injecting 10 % filtered fecal suspension into the abdominal cavity. Obesity was simulated using a high-calorie diet. The content of indicators of endogenous intoxication in the blood of animals was determined using the photospectrometric method.

Results and Discussion. It was established that in animals with АGP against the background of obesity, the indicators of lipoperoxidation were significantly activated (by 1.8 times the level of TBА-AP compared to intact animals) and the antioxidant defense was depleted (according to a statistically significantly lower index of superoxide dismutase by 2.4 times compared to the control) ) (p <0.05).

Conclusions. The development of AGP is accompanied by the EIS complex, which indicates an increase in catabolic processes in the dynamics of pathology modeling, and is laboratory-detected by a probable increase in the levels of MSM, EII. The depth of endotoxemia in rats increases during all stages of development of acute peritonitis and depends on the presence of accompanying obesity, which is confirmed by significantly higher levels of MM254 and MM280, EII during all observed terms of animals with combined pathology.
ВПЛИВ КАЛЬЦИТРІОЛУ НА ПРОДУКУВАННЯ ГІДРОГЕН СУЛЬФІДУ В СЕРЦЕВО-СУДИННІЙ СИСТЕМІ ЩУРІВ
Authors: Остренюк Р. С. , Заічко Н. В.
Published: November 2023

Вступ. Порушення статусу вітаміну D є незалежним чинником високого кардіоваскулярного ризику, артеріальної гіпертензії, коронаросклерозу, інфаркту міокарда. Встановлено безпосередню участь активної форми вітаміну D (кальцитріолу) в регуляції проліферації, клітинної адгезії, мембранного транс­порту в серцево-судинній системі. В окремих роботах засвідчено бустерний вплив вітаміну D на рівень поліфункціонального газового медіатора гідроген сульфіду (H2S) у тканинах. Однак участі кальцитріолу в регуляції різних ланок обміну H2S у серці та судинах остаточно не з’ясовано, і вона потребує подальшого вивчення.
Мета дослідження – встановити вплив кальцитріолу на різні ланки обміну гідроген сульфіду в аорті й міокарді щурів.
Методи дослідження. Досліди проведено на 105 білих лабораторних щурах-самцях з дотриманням принципів біоетики. Кальцитріол вводили внутрішньошлунково в дозах 0,1 та 1,0 мкг/кг маси тварини впродовж 4 тижнів. Контрольні щури отримували еквіоб’ємну кількість розчинника. У гомогенатах аорти і міокарда визначали рівень Н2S та активність ензимів його обміну. Експресію гена цистатіонін-γ-ліази (CSE) визначали методом кількісної полімеразно-ланцюгової реакції в режимі реального часу (qRT-PCR). Статистичну обробку результатів проводили в пакетах МS Excel та IBM Statistics SPSS 26 for Windows. Достовірність відмінностей оцінювали за U-критерієм Манна – Уїтні при рівні значущості р<0,05.
Результати й обговорення. Кальцитріол спричиняв різновекторні зміни обміну H2S у серцево-судинній системі залежно від дози і тривалості застосування. У дозі 0,1 мкг/кг він викликав збільшення рівня H2S в аорті й міокарді щурів, підвищення активності ензимів його синтезу та утилізації впродовж 4 тижнів досліду, в дозі 1,0 мкг/кг – зростання рівня H2S в аорті й міокарді тварин протягом перших 14 діб, але в подальшому справляв депримуючий ефект на ензими обміну H2S і зумовлював зниження його рівня в аорті й міокарді щурів. Кальцитріол впливав на експресію гена СSE в аорті й міокарді щурів із стимулювальним ефектом у дозі 0,1 мкг/кг та інгібуючим ефектом у дозі 1,0 мкг/кг.
Висновки. Кальцитріол є регулятором активності різних ланок обміну H2S у серцево-судинній системі щурів: у високих дозах він суттєво пригнічує активність H2S-синтезувальних ензимів та ензимів утилізації H2S в аорті й міокарді, а у фізіологічних концентраціях, навпаки, стимулює його продукування. Феномен впливу кальцитріолу на систему H2S є важливим для вибору стратегії профілактики захворювань серцево-судинної системи при різному статусі вітаміну D3.
ВПЛИВ ДУЛОКСЕТИНУ НА КЛІНІЧНИЙ ПЕРЕБІГ ТА БІОХІМІЧНІ ПОКАЗНИКИ У ПАЦІЄНТІВ ІЗ ХРОНІЧНИМИ ВЕРТЕБРОГЕННИМИ ПОПЕРЕКОВО-КРИЖОВИМИ БОЛЬОВИМИ СИНДРОМАМИ
Authors: Кулик А. Р. , Паєнок А. В. , Сойка Л. Д. , Лаповець Л. Є. , Бойків Н. Д. , Ткачук С. О. , Луців Н. З. , Дем’янчук Н. Р.
Published: November 2023

Вступ. Хронічний біль у нижній частині спини – джерело страждань мільйонів людей, а також одна з основних причин інвалідизації населення в розвинутих країнах світу. На жаль, сьогодні не існує однозначного уявлення про патогенез хронічного болю, а також узагальненого послідовного підходу до лікування. Формування хронічного болю – складний та багатогранний процес, на який можуть впливати різні фактори. У статті проаналізовано клінічний перебіг больового синдрому, проаналізовано показники тривожності, депресії, якості життя та оцінено рівні субстанції Р і кортизолу в крові пацієнтів на тлі лікування дулоксетином.

Мета дослідження – оцінити вплив дулоксетину на клінічний перебіг та біохімічні показники у пацієнтів із хронічними вертеброгенними попереково-крижовими больовими синдромами після комплексного стаціонарного лікування.

Методи дослідження. Проведено комплексне клінічне обстеження та визначення біохімічних показників (кортизолу і субстанції Р) у сироватці крові 45 пацієнтів (середній вік – (41,2±11,2) року, кількість чоловіків – 26 (57,7 %), кількість жінок – 19 (42,3 %)). Біохімічні показники визначали методом імуноферментного аналізу без екстракції в зразках сироватки крові.

Результати й обговорення. Через 8 тижнів приймання дулоксетину в дозі 60 мг 1 раз на день у пацієнтів із хронічними вертеброгенними попереково-крижовими больовими синдромами зменшилось вираження больового синдрому, вірогідно (р<0,05) знизилась поширеність клінічних симптомів (напруження мʼязів спини, анталгічного сколіозу, симптому Ласега), покращилась рухомість поперекового відділу хребта (за даними пальце-підлогової проби, з (23,12±2,31) до (16,46±2,26) см). Також вірогідно зменшились показники тривожності, депресії та поліпшилась якість життя (р<0,05). Рівень субстанції Р у крові знизив­ся з (8,25±2,35) до (6,11±2,71) нг/мл, а кортизолу – з (379,3±93,1) до (212,2±88,0) нмоль/л (p>0,05).

Висновок. Призначення дулоксетину після закінчення стаціонарного лікування пацієнтів із хронічними вертеброгенними попереково-крижовими больовими синдромами приводить до покращення клінічних метрик, зменшення вмісту кортизолу і субстанції Р у крові.