bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Characterization and Pathogenicity of an Infectious cDNA Clone of Youcai Mosaic Virus on Solanum nigrum
Authors: Gu Tianxiao , Feng Chenwei , Hua Yanhong , Liu Duxuan , Chen Haoyu , He Zhen , Xu Kai , Zhang Kun
Published: January 2024

Virus infections cause devastative economic losses for various plant species, and early diagnosis and prevention are the most effective strategies to avoid the losses. Exploring virus genomic evolution and constructing virus infectious cDNA clones is essential to achieve a deeper understanding of the interaction between host plant and virus. Therefore, this work aims to guide people to better prevent, control, and utilize the youcai mosaic virus (YoMV). Here, the YoMV was found to infect the Solanum nigrum under natural conditions. Then, an infectious cDNA clone of YoMV was successfully constructed using triple-shuttling vector-based yeast recombination. Furthermore, we established phylogenetic trees based on the complete genomic sequences, the replicase gene, movement protein gene, and coat protein gene using the corresponding deposited sequences in NCBI. Simultaneously, the evolutionary relationship of the YoMV discovered on S. nigrum to others was determined and analyzed. Moreover, the constructed cDNA infectious clone of YoMV from S. nigrum could systematically infect the Nicotiana benthamiana and S. nigrum by agrobacterium-mediated infiltration. Our investigation supplied a reverse genetic tool for YoMV study, which will also contribute to in-depth study and profound understanding of the interaction between YoMV and host plant.
Photobiomodulation for Neurodegenerative Diseases: A Scoping Review
Authors: Shen Qi , Guo Haoyun , Yan Yihua
Published: January 2024

Neurodegenerative diseases involve the progressive dysfunction and loss of neurons in the central nervous system and thus present a significant challenge due to the absence of effective therapies for halting or reversing their progression. Based on the characteristics of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), which have prolonged incubation periods and protracted courses, exploring non-invasive physical therapy methods is essential for alleviating such diseases and ensuring that patients have an improved quality of life. Photobiomodulation (PBM) uses red and infrared light for therapeutic benefits and functions by stimulating, healing, regenerating, and protecting organizations at risk of injury, degradation, or death. Over the last two decades, PBM has gained widespread recognition as a non-invasive physical therapy method, showing efficacy in pain relief, anti-inflammatory responses, and tissue regeneration. Its application has expanded into the fields of neurology and psychiatry, where extensive research has been conducted. This paper presents a review and evaluation of studies investigating PBM in neurodegenerative diseases, with a specific emphasis on recent applications in AD and PD treatment for both animal and human subjects. Molecular mechanisms related to neuron damage and cognitive impairment are scrutinized, offering valuable insights into PBM’s potential as a non-invasive therapeutic strategy.
Chondroitin Sulfate Proteoglycan 4 Provides New Treatment Approach to Preventing Peritoneal Dissemination in Ovarian Cancer
Authors: Uno Kaname , Koya Yoshihiro , Yoshihara Masato , Iyoshi Shohei , Kitami Kazuhisa , Sugiyama Mai , Miyamoto Emiri , Mogi Kazumasa , Fujimoto Hiroki , Yamakita Yoshihiko , Wang Xinhui , Nawa Akihiro , Kajiyama Hiroaki
Published: January 2024

Most epithelial ovarian cancer (EOC) patients are diagnosed with peritoneal dissemination. Cellular interactions are an important aspect of EOC cells when they detach from the primary site of the ovary. However, the mechanism remains underexplored. Our study aimed to reveal the role of chondroitin sulfate proteoglycan 4 (CSPG4) in EOC with a major focus on cell–cell interactions. We examined the expression of CSPG4 in clinical samples and cell lines of EOC. The proliferation, migration, and invasion abilities of the CSPG4 knockdown cells were assessed. We also assessed the role of CSPG4 in spheroid formation and peritoneal metastasis in an in vivo model using sh-CSPG4 EOC cell lines. Of the clinical samples, 23 (44.2%) samples expressed CSPG4. CSPG4 was associated with a worse prognosis in patients with advanced EOC. Among the EOC cell lines, aggressive cell lines, including ES2, expressed CSPG4. When CSPG4 was knocked down using siRNA or shRNA, the cell proliferation, migration, and invasion abilities were significantly decreased compared to the control cells. Proteomic analyses showed changes in the expression of proteins related to the cell movement pathways. Spheroid formation was significantly inhibited when CSPG4 was inhibited. The number of nodules and the tumor burden of the omentum were significantly decreased in the sh-CSPG4 mouse models. In the peritoneal wash fluid from mice injected with sh-CSPG4 EOC cells, significantly fewer spheroids were present. Reduced CSPG4 expression was observed in lymphoid enhancer-binding factor 1-inhibited cells. CSPG4 is associated with aggressive features of EOC and poor prognosis. CSPG4 could be a new treatment target for blocking peritoneal metastasis by inhibiting spheroid formation.
Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons
Authors: Liu Shuyi , Shi Liping , Huang Tianzhuang , Luo Yuyi , Chen Yongchang , Li Shangang , Wang Zhengbo
Published: January 2024

Cortical traumatic brain injury (TBI) is a major cause of cognitive impairment accompanied by motor and behavioral deficits, and there is no effective treatment strategy in the clinic. Cell transplantation is a promising therapeutic strategy, and it is necessary to verify the survival and differentiation of cells after transplantation in large animal models like rhesus monkeys. In this study, we transplanted neural stem cells (NSCs) and simultaneously injected basic fibroblast growth factor/epidermal growth factor (bFGF/EGF) into the cortex (visual and sensory cortices) of rhesus monkeys with superficial TBI. The results showed that the transplanted NSCs did not enter the cerebrospinal fluid (CSF) and were confined to the transplantation site for at least one year. The transplanted NSCs differentiated into mature neurons that formed synaptic connections with host neurons, but glial scar formation between the graft and the host tissue did not occur. This study is the first to explore the repairing effect of transplanting NSCs into the superficial cerebral cortex of rhesus monkeys after TBI, and the results show the ability of NSCs to survive long-term and differentiate into neurons, demonstrating the potential of NSC transplantation for cortical TBI.
Ring Opening Polymerization of Six- and Eight-Membered Racemic Cyclic Esters for Biodegradable Materials
Authors: Grillo Andrea , Rusconi Yolanda , D'Alterio Massimo Christian , De Rosa Claudio , Talarico Giovanni , Poater Albert
Published: January 2024

The low percentage of recyclability of the polymeric materials obtained by olefin transition metal (TM) polymerization catalysis has increased the interest in their substitution with more eco-friendly materials with reliable physical and mechanical properties. Among the variety of known biodegradable polymers, linear aliphatic polyesters produced by ring-opening polymerization (ROP) of cyclic esters occupy a prominent position. The polymer properties are highly dependent on the macromolecule microstructure, and the control of stereoselectivity is necessary for providing materials with precise and finely tuned properties. In this review, we aim to outline the main synthetic routes, the physical properties and also the applications of three commercially available biodegradable materials: Polylactic acid (PLA), Poly(Lactic-co-Glycolic Acid) (PLGA), and Poly(3-hydroxybutyrate) (P3HB), all of three easily accessible via ROP. In this framework, understanding the origin of enantioselectivity and the factors that determine it is then crucial for the development of materials with suitable thermal and mechanical properties.
Broccoli Cultivated with Deep Sea Water Mineral Fertilizer Enhances Anti-Cancer and Anti-Inflammatory Effects of AOM/DSS-Induced Colorectal Cancer in C57BL/6N Mice
Authors: Lee Yeon-Jun , Pan Yanni , Lim Daewoo , Park Seung-Hwan , Sin Sin-Il , Kwack KyuBum , Park Kun-Young
Published: January 2024

This study aimed to determine the alleviating effect of broccoli grown with deep sea water mineral (DSWM) fertilizer extracted from deep sea water on the development of colorectal cancer in C57BL/6N mice treated with AOM/DSS. Naturaldream Fertilizer Broccoli (NFB) cultured with deep sea water minerals (DSWM) showed a higher antioxidant effect and mineral content. In addition, orally administered NFB, showed a level of recovery in the colon and spleen tissues of mice compared with those in normal mice through hematoxylin and eosin (H&E) staining. Orally administered NFB showed the inhibition of the expression of inflammatory cytokine factors IL-1β, IL-6, TNF, IFN-γ, and IL-12 while increasing the expression of IL-10. Furthermore, the expression of inflammatory cytokines and NF-κB in the liver tissue was inhibited, and that of inflammatory enzymes, such as COX-2 and iNOS, was reduced. In the colon tissue, the expression of p53 and p21 associated with cell cycle arrest increased, and that of Bcl-2 associated with apoptosis decreased. Additionally, the expression of Bax, Bad, Bim, Bak, caspase 9, and caspase 3 increased, indicating enhanced activation of apoptosis-related factors. These results demonstrate that oral administration of broccoli cultivated using DSWM significantly restores spleen and colon tissues and simultaneously inhibits the NF-κB pathway while significantly decreasing cytokine expression. Moreover, by inducing cell cycle arrest and activating cell apoptosis, they also suggest alleviating AOM/DSS-induced colon cancer symptoms in C57BL/6N mice.
Muscular Strategies for Correcting the Pelvic Position to Improve Posture—An Exploratory Study
Authors: Ludwig Oliver , Dindorf Carlo , Kelm Sebastian , Kelm Jens , Fröhlich Michael
Published: January 2024

The correction of postural weaknesses through the better positioning of the pelvis is an important approach in sports therapy and physiotherapy. The pelvic position in the sagittal plane is largely dependent on the muscular balance of the ventral and dorsal muscle groups. The aim of this exploratory study was to examine whether healthy persons use similar muscular activation patterns to correct their pelvic position or whether there are different motor strategies. The following muscles were recorded in 41 persons using surface electromyography (EMG): M. trapezius pars ascendens, M. erector spinae pars lumbalis, M. gluteus maximus, M. biceps femoris, M. rectus abdominis, and M. obliquus externus. The participants performed 10 voluntary pelvic movements (retroversion of the pelvis). The anterior pelvic tilt was measured videographically via marker points on the anterior and posterior superior iliac spine. The EMG data were further processed and normalized to the maximum voluntary contraction. A linear regression analysis was conducted to assess the relationship between changes in the pelvic tilt and muscle activities. Subsequently, a Ward clustering analysis was applied to detect potential muscle activation patterns. The differences between the clusters and the pelvic tilt were examined using ANOVA. Cluster analysis revealed the presence of four clusters with different muscle activation patterns in which the abdominal muscles and dorsal muscle groups were differently involved. However, the gluteus maximus muscle was involved in every activation pattern. It also had the strongest correlation with the changes in pelvic tilt. Different individual muscle patterns are used by different persons to correct pelvic posture, with the gluteus maximus muscle apparently playing the most important role. This can be important for therapy, as different muscle strategies should be trained depending on the individually preferred motor patterns.
Will Endoscopic-Ultrasound-Guided Choledocoduodenostomy with Electrocautery-Enhanced Lumen-Apposing Metal Stent Placement Replace Endoscopic Retrograde Cholangiopancreatography When Treating Distal Malignant Biliary Obstructions?
Authors: Guilmoteau Thomas , Albouys Jérémie , Taibi Abdelkader , Legros Romain , Schaefer Marion , Jacques Jérémie
Published: January 2024

Malignant distal biliary obstructions are becoming increasingly common, especially in patients with cancers of the pancreatic head, despite progress in medical oncology research. ERCP is the current gold standard for management of such strictures, but the emergence of EC-LAMS has rendered EUS-CDS both safe and efficient. It is a “game changer”; originally intended for ERCP failure, two randomised clinical trials recently proposed EUS-CDS as a first-intent procedure in palliative settings. For resectable diseases, the absence of iatrogenic pancreatitis associated with a lower rate of postsurgical adverse events (compared with ERCP) leads us to believe that EUS-CDS might be used in first-intent as a pre-operative endoscopic biliary drainage.
Corrugator Muscle Activity Associated with Pressure Pain in Adults with Neck/Shoulder Pain
Authors: Yamada Takahiro , Yajima Hiroyoshi , Takayama Miho , Imanishi Konomi , Takakura Nobuari
Published: January 2024

Background and Objectives: No studies have reported corrugator muscle activity associated with pain in people with pain. This study aimed to develop an objective pain assessment method using corrugator muscle activity with pressure pain stimulation to the skeletal muscle. Methods: Participants were 20 adults (a mean ± SD age of 22.0 ± 3.1 years) with chronic neck/shoulder pain. Surface electromyography (sEMG) of corrugator muscle activity at rest (baseline) and without and with pressure pain stimulation applied to the most painful tender point in the shoulder was recorded. Participants evaluated the intensity of the neck/shoulder pain and the sensory and affective components of pain with pressure stimulation using a visual analogue scale (VAS). The percentages of integrated sEMG (% corrugator activity) without and with pressure pain stimulation to the baseline integrated sEMG were compared, and the relationships between the % corrugator activity and the sensory and affective components of pain VAS scores were evaluated. Results: Without pressure stimulation, an increase in corrugator muscle activity due to chronic neck/shoulder pain was not observed. The % corrugator activity with pressure pain stimulation was significantly higher than that without stimulation (p < 0.01). A significant positive correlation between corrugator muscle activity and the affective components of pain VAS scores with pressure stimulation was found (ρ = 0.465, p = 0.039) and a tendency of positive correlation was found for the sensory component of pain VAS scores (ρ = 0.423, p = 0.063). Conclusions: The increase in corrugator muscle activity with pressure pain stimulation to the tender point in adults with chronic neck/shoulder pain was observed, although increased corrugator muscle activity resulting from the chronic neck/shoulder pain was not. These findings suggest that corrugator muscle activity with pressure pain stimulation can be a useful objective indication for tender point sensitivity assessment in the skeletal muscle with pain.
Sex Differences in Sarcopenia in Patients Undergoing Total Knee Arthroplasty for Advanced Knee Osteoarthritis
Authors: Shon Oog-Jin , Kim Gi Beom , Jo Seong Hyeon
Published: January 2024

Background and Objectives: The purpose of this study was to compare sex differences in the incidence of sarcopenia, demographic characteristics, and preoperative sarcopenic parameters in patients undergoing TKA for advanced knee osteoarthritis (OA). Moreover, we sought to compare patient-reported outcome measures (PROMs) and the predisposing factors after TKA in patients with sarcopenia by sex through subgroup analysis. Materials and Methods: From May 2020 to September 2022, a total of 892 patients who were evaluable for sarcopenia before primary TKA were enrolled. Sarcopenia was defined according to the Asian Working Group for Sarcopenia 2019 criteria. Patients were assessed according to the presence or absence of sarcopenia. After a two-to-one matched-pair analysis for subgroup analysis, 21 knees in men were matched with a corresponding number of knees in women (42), resulting in a total of 63 knees. PROMs were investigated using the Knee Injury and Osteoarthritis Outcome Score, Western Ontario and McMaster Universities Osteoarthritis Index, and the Short Form-12 physical and mental component summary scores. Moreover, the postoperative complications and predisposing factors for male sarcopenia were investigated. Results: The prevalence of sarcopenia was 10.9% (97/892), and the prevalence was higher in men (19.6%, 21/107) than in women (9.7%, 76/785). In subgroup analyses, male patients had significantly inferior PROMs up to 12 months after index surgery. Moreover, there was no significant difference in the systemic complications between the two groups. Multivariate binary logistic regression analysis indicated that alcohol consumption, smoking, and higher modified Charlson Comorbidity Index (mCCI) were predisposing factors for male patients with sarcopenia. The prevalence of sarcopenia was higher in male patients undergoing primary TKA. Conclusions: When compared with the propensity-matched female group, male patients had inferior PROMs up to 12 months postoperatively. Alcohol consumption, current smoker status, and higher mCCI were predisposing factors for sarcopenia in male patients with advanced knee OA.
An Epidemiological Study on Legionnaires’ Disease in Gyeonggi Province, Korea: Occurrence, Infection Routes, and Risk Factors for Mortality (2016–2022)
Authors: Noh Hae-Deun , Oh Jeonghyeon , Park Kun-Hee , Park Boyoung
Published: January 2024

Background and Objectives: Legionnaires’ disease (LD) is an acute respiratory disease with increasing annual numbers of reported domestic and global cases. This study aimed to establish foundational data for the prevention and control of LD by investigating the occurrence and infection routes of reported and suspected cases of LD in Gyeonggi Province, Korea, from January 2016 to December 2022, and by and analyzing the risk factors for death. Materials and Methods: A sex-and-age standardization was performed on LD patients and suspected cases reported in Gyeonggi Province. The monthly average number of confirmed cases was visualized using graphs, and a survival analysis was performed using Kaplan–Meier survival curves. The mortality risk ratio was estimated using the Cox proportional hazards model. Results: The incidence of LD in Gyeonggi Province mirrored the national trend, peaking in July with the highest number of confirmed and suspected cases. While there was no significant difference in survival rates by age, the survival rate was higher for suspected cases when analyzed separately. Comparing the death ratio by infection route, nosocomial infections showed the highest death ratio, and intensive care unit (ICU) admission and the presence of coinfections were significantly correlated with mortality. Factors such as nosocomial infection, admission within 1 to 3 days following diagnosis, and the development of complications were factors contributing to a higher risk of death. Conclusions: The general characteristics of patients with LD were similar to those suggested by previous studies. The proportion of community-acquired infections was lower than in previous studies, but the length of hospital stay was similar for survivors and the deceased, and the mortality rate within 30 days after diagnosis was higher for nosocomial infections. In conclusion, nosocomial infection, a period of up to 3 days from admission to diagnosis, and complications were significantly related to the mortality rate of LD.
Small Bowel Diverticulosis and COVID-19: Awareness Is the Key: A Case Series and Review of the Literature
Authors: Bangeas Petros , Konstantinidis Nikolaos , Chrisopoulou Tania , Karatzia Despoina , Giakoustidis Alexandros , Papadopoulos Vasileios
Published: January 2024

Small bowel non-Meckelian diverticulosis is a rare condition with only a few published cases despite being described over 200 years ago. In the midst of the COVID-19 pandemic, studies suggested that many patients may experience gastrointestinal manifestations. Intestinal symptoms could worsen the inflammation and infection associated with small bowel diverticulitis. Here we present three cases: one with inflammation and rupture in a COVID-19 patient and another as an asymptomatic detection. The third case involved recurrence after the first laparoscopic lavage approach. Furthermore, we provide a mini-review of the literature to emphasize the importance of considering this entity in the differential diagnosis of an acute abdomen. In the majority of cases involving small bowel diverticula, conservative management is the preferred approach. However, when complications arise, surgical intervention, including enteroctomy and primary anastomosis, may be necessary to achieve optimal outcomes.
Preconceptional Counseling in Women with Hyperthyroidism
Authors: Cima Luminita Nicoleta , Tarna Mihaela , Martin Carmen Sorina , Sirbu Anca Elena , Soare Iulia , Panaitescu Anca Maria , Gica Nicolae , Barbu Carmen Gabriela , Fica Simona
Published: January 2024

Preconception evaluation of couples wishing to conceive is an important step toward a healthy pregnancy and it is especially important in people with a chronic condition or at genetic risk. The most common endocrine disorders in women at reproductive age are those involving the thyroid gland and it is well recognized that hyperthyroidism (HT), over-function of the thyroid gland, is associated with risks of maternal, fetal, and neonatal complications. The aim of this paper is to review the latest evidence regarding the components of preconception counseling in women with HT that contemplate a pregnancy. We also want to raise awareness among healthcare professionals about the importance of periconceptional counseling in improving pregnancy outcomes and avoid maternal and fetal complications related to thyroid dysfunction. In women with Graves’ disease seeking pregnancy, it is essential to discuss all the treatment options along with the associated risks and benefits. Extensive prospective studies are still needed to understand the implications of current recommended strategies for the management of HT in preconception and during pregnancy.
Next-Generation Sequencing in Lung Cancers—A Single-Center Experience in Taiwan
Authors: Lai Wei-An , Huang Yen-Shuo , Chang Kung-Chao , Yang Sheau-Fang , Yang Chih-Jen , Liu Yu-Wei , Chen Huan-Da
Published: January 2024

Background and Objectives: Lung cancer is a leading cause of cancer mortality in Taiwan. With rapid advancement of targeted therapeutics in non-small cell lung cancers, next-generation sequencing (NGS) is becoming an important tool for biomarker testing. In this study, we describe institutional experience of NGS analysis in non-small cell carcinoma (NSCLC). Materials and Methods: A cohort of 73 cases was identified from the institutional pathology archive in the period between November 2020 and December 2022. Results: Adenocarcinoma was the most common histologic type (91.8%). Most patients presented with stage IIIB and beyond (87.7%). Twenty-nine patients (39.7%) were evaluated at the time of initial diagnosis, while the others had received prior chemotherapy or targeted therapy. The most frequently mutated gene was EGFR (63%), and this was followed by TP53 (50.7%), KRAS (13.7%), RB1 (13.7%), and CDKN2A (13.7%). Clinically actionable mutations associated with a guideline-suggested targeted therapy were identified in 55 cases (75.3%) overall, and in 47.1% of cases excluding EGFR TKI-sensitizing mutation. Biomarkers other than EGFR TKI-sensitizing mutations were compared. Cases without TKI-sensitizing EGFR mutation had more level 1 or 2 biomarkers (excluding EGFR TKI-sensitizing mutations) than cases with TKI-sensitizing EGFR mutations (47.1% versus 20.1%, p = 0.016). Progressive disease was associated with co-occurrence of clinically actionable mutations (20.5% versus 0%, p < 0.05). Eight of the nine cases with co-occurring actionable genetic alternations had an EGFR mutation. After an NGS test, 46.1% of actionable or potentially actionable genetic alternations led to patients receiving a matched therapy. Conclusions: Our study demonstrated that NGS analysis identifies therapeutic targets and may guide treatment strategies in NSCLC. NGS tests may be advantageous over multiple single-gene tests for optimization of treatment plans, especially for those with non-EGFR mutations or those with progressive disease.
Determination of Perfluorinated and Polyfluorinated Alkyl Substances (PFASs) in PM10 Samples: Analytical Method, Seasonal Trends, and Implications for Urban Air Quality in the City of Terni (Central Italy)
Authors: Moretti Simone , Castellini Silvia , Barola Carolina , Bucaletti Elisabetta , Petroselli Chiara , Selvaggi Roberta , Galletti Mara , Cappelletti David , Galarini Roberta
Published: January 2024

A quantitative analytical method for PFAS determination in airborne particulate matter (PM) has been developed using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS), allowing for the determination of 33 compounds. The procedure was applied to ambient PM10 with limits of quantification for PFAS in the fg m−3 range. PM10 samples collected during a year-long campaign conducted in an urban site in Umbria (Central Italy) have been characterized for their PFAS content. Among the seven detected PFASs, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) were the most abundant compounds. Furthermore, this work allowed us to obtain the first seasonal trend of airborne PFASs in Central Italy. Seasonal trend analysis shows that PFAS concentration in the atmosphere peaks in summertime. A comparison with trends of other relevant primary and secondary air pollutants determined at the sampling site suggests a secondary nature of the observed PFAS, which are formed in the atmosphere directly from gaseous precursors and can contribute to worsen the urban air quality in summertime.
Investigating How Corporate Social Responsibility Affects Employees’ Thriving at Work: A Social Exchange Perspective
Authors: Han Xue , Li Qinyi , Wang Xinyi
Published: January 2024

Corporate social responsibility (CSR) helps enterprises achieve sustainable development in the current competitive environment. Premised on social exchange theory, we argue that CSR also contributes to employees’ sustainable development, which can be gauged by thriving at work. We conducted a three-wave questionnaire survey to examine our hypothesized model. We found that employees’ perceived CSR helps employees to build a good social exchange with their company, which in turn contributes to enhanced thriving at work. Further, for employees with higher levels of trait gratitude, CSR is more likely to facilitate their social exchange and subsequent thriving at work. Our findings enrich the nomological network of CSR and thriving, and provide insights for organizations to build a thriving and sustainable workforce.
Digital Mergers and Acquisitions and Enterprise Innovation Quality: Analysis Based on Research and Development Investment and Overseas Subsidiaries
Authors: Xu Helian , Deng Shiqi
Published: January 2024

Utilizing a hand-collected dataset on digital cross-border mergers and acquisitions (M&As), we conducted an exploratory study about the effect of digital overseas M&As on the innovative quality of acquiring enterprises. Based on the digital cross-border M&A behavior of Chinese listed firms from 2010 to 2022, we offer original and robust evidence that reveals that enterprises engaging in digital cross-border M&As are more likely to produce high-quality innovations and services, and this effect may be moderated by human capital. Our explorations specifically reveal that the increase in quality of innovation from digital cross-border M&As could occur through research and development (R&D) investment and overseas subsidiaries. In addition, we found that the positive effect is especially pronounced in enterprises located in the Eastern and Western regions, and it also exists among high-tech enterprises, relatively large-scale enterprises, and digital-acquiring enterprises. We conclude by discussing how important it is for M&A enterprises to use digital technology to shape innovation quality.
Functional and Operatorial Equations Defined Implicitly and Moment Problems
Authors: Olteanu Octav
Published: January 2024

The properties of the unique nontrivial analytic solution, defined implicitly by a functional equation, are pointed out. This work provides local estimations and global inequalities for the involved solution. The corresponding operatorial equation is studied as well. The second part of the paper is devoted to the full classical moment problem, which is an inverse problem. Two constraints are imposed on the solution. One of them requires the solution to be dominated by a concrete convex operator defined on the positive cone of the domain space. A one-dimensional operator is valued, and a multidimensional scalar moment problem is solved. In both cases, the existence and the uniqueness of the solution are proved. The general idea of the paper is to provide detailed information on solutions which are not expressible in terms of elementary functions.
Safety of dabigatran
Authors:   Federal State Autonomous Educational Institution of Higher Education «Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation, Schneider K. O. , Kondrakhin A. P. ,   Federal State Autonomous Educational Institution of Higher Education «Pirogov Russian National Research Medical University», Moscow Healthcare Department, State Budgetary Healthcare Institution of Moscow «Hospital for War Veterans No. 2 of the Moscow Healthcare Department», Maksimov M. L. ,   Federal State Autonomous Educational Institution of Higher Education «Pirogov Russian National Research Medical University», 5Kazan State Medical Academy — Branch Campus of the Federal State Budgetary Educational Institution of Continuing Professional Education «Russian Medical Academy of Continuous Professional Education»
Published: January 2024

Thrombosis ranks first among the leading causes of death worldwide and is a fatal risk factor for patients’ health. Rapid diagnosis and appropriate treatment are necessary. There are three categories of antithrombotic agents: antiplatelet agents, anticoagulants, and fibrinolytics. Anticoagulants are first-line therapy for the prevention and treatment of venous thrombi. Dabigatran etexilate is a direct thrombin inhibitor. The effectiveness of dabigatran has been demonstrated in several clinical studies for the prevention of venous thromboembolism in patients undergoing total hip or total knee arthroplasty, for the prevention of stroke in patients with non-valvular atrial fibrillation, and in the treatment of acute venous thromboembolism. Some studies have demonstrated that the use of dabigatran leads to an increased risk of bleeding. Therefore, the purpose of this review is to examine the safety of dabigatran in patients over 18 years of age. We identified potentially relevant studies by searching the electronic databases PubMed, Web of Science, Cochrane Library, MEDLINE, and Google Scholar. Further, according to the inclusion and exclusion criteria, as well as by means of independent selection, all the authors of this article selected the sources that were suitable according to the criteria and compiled this review.
The structure of anxiety and depressive disorders in patients of the neurological hospital
Authors:   Russian State Research Center − Burnasyan Federal Medical Biophysical Center of the Federal Medical Biological Agency of Russia, Fokina E. E.
Published: January 2024

The article analyzes the structure of anxiety-depressive disorders in neurological hospital patients. The study used validated scales: the Hospital Anxiety and Depression Scale (HADS) and the scale for assessing the level of reactive and personal anxiety (developed by C. D. Spielberger and adapted by Yu. L. Khanin). The author comes to the conclusion that more than a half of the patients surveyed experience feelings of anxiety or depression at subclinical and severe levels. In addition, in patients with anxiet y trait anxiety predominates.
SISTEMA AUTÓNOMO DE LIMPIEZA PARA PANELES SOLARES AUTONOMOUS CLEANING SYSTEM FOR SOLAR PANELS
Authors: García Zambrano Yilliam Ricardo
Published: January 2024

Se construyó un sistema de limpieza autónomo programable para paneles fotovoltaicos, teniendo como objetivo principal mantener su limpieza de una manera eficiente, en conjunto con una relación calidad, mejorando así la eficacia del panel fotovoltaico, su tiempo de vida útil, en conjunto a una mejor estética, este proyecto ayuda a eliminar los posibles accidentes que se puedan suscitar al momento de realizar una limpieza de manera manual evitando caídas y otras dificultades al ser humano. El objetivo fue diseñar un sistema automático de limpieza de paneles fotovoltaicos en el sistema de práctica que se encuentra ubicado en la terraza del edificio 1, de la facultad de Ciencias, Matemáticas, Físicas y Químicas. Se realizó una búsqueda bibliográfica, y el método inductivo deductivo y un trabajo de campo. Se obtuvo como resultado el sistema de control de limpieza mediante un mecanismo que funciona básicamente con un régimen de escobillas individuales a cada panel.
Fortalecimiento de capacidades locales de estudiantes y docentes de la unidad educativa particular ITSI Chone, mediante una estrategia de educación ambiental
Authors: VELEZ MENDOZA NAVIGIO ALEXANDER
Published: January 2024

El presente trabajo de investigación tuvo como objetivo principal, evaluar el fortalecimiento de las capacidades locales de estudiantes y docentes de la Unidad Educativa Particular ITSI Chone mediante una estrategia de educación ambiental. Se utilizó la metodología propuesta en PNUD (2009) aplicada en procesos de enseñanza y aprendizaje en los estudiantes y docentes, constó de cinco pasos, los cuales fueron; participación, formulación e implementación de respuesta, diagnóstico y evaluación de capacidades, que permitieron el desarrollo de las capacidades locales y actores involucrados, además, se aplicó un programa de capacitación como estrategia de educación ambiental, el cumplimiento de éste se desarrolló en Modalidad Híbrida “Distancia-Virtual”. Los resultados del diagnóstico inicial obtenidos, mostraron que los actores involucrados en la investigación no contaban con conocimientos sobre educación ambiental, así como sobre desarrollo sostenible debido a la falta de capacitaciones sobre dichos temas. El trabajo efectuado con los grupos participantes, otorgó sensibilidad ante los temas propuestos y estadísticamente se determinó que la estrategia influyó significativamente (p = 0,001) en el fortalecimiento de las capacidades locales (p<0,05), corroborando que los resultados del nivel de desempeño de los estudiantes y docentes post educación ambiental se encontró en un nivel de “Bueno” a “Muy Bueno”.
Sistema de automatización para la obtención de información de la central fotovoltaica de 3,4 kWp
Authors: Cajape Palma Joseph Joaquín
Published: January 2024

En la era de la energía sostenible, los sistemas fotovoltaicos se han convertido en una solución cada vez más necesaria y popular. En este artículo, se mostrará una innovación que permitió el monitoreo de sistemas fotovoltaicos de 3,4 kWp instalado en la terraza del edificio 1 de la Facultad de Ciencias Matemática, Físicas y Químicas, el objetivo fue diseñar un sistema de control que permite recoger los datos de tensión, corriente y potencia del sistema. Se utilizó una variante con la app móvil Oxley Solar Pro. Se obtuvo como resultado un sistema automatizado, que permite monitorear en tiempo real la generación del sistema, la tensión y la corriente.
Curvas Intensidad Duración Frecuencia y hietograma de una precipitación sintética para la cuenca del Río Chone
Authors: Giler-Medina Patricio
Published: January 2024

La hidrometeorología de la cuenca del río Chone se enfrenta a diversos escenarios que conducen a inundaciones interanuales. El propósito de la investigación fue establecer la respuesta de una precipitación sintética en base a la relación entre la intensidad de un aguacero, la duración y la recurrencia en períodos de diseño. Se utilizó la metodología de las curvas Intensidad Duración Frecuencia y el método del bloque alterno en la elaboración del hietograma de trabajo. La aplicación de la ecuación de Bernard permitió obtener una precipitación ajustada de 289 mm cada 100 años. Finalmente, la hidrometeorología de la cuenca demostró que en una duración de 30 minutos se generaría una precipitación máxima de 24.5 mm en un período de retorno cada 100 años.
A Review of Strategies to Improve the Stability of Carbon-supported PtNi Octahedral for Cathode Electrocatalysts in Polymer Electrolyte Membrane Fuel Cells
Authors: Kim In Gyeom , Yoo Sung Jong , Kim Jin Young , Park Hyun S. , Lee So Young , Seo Bora , Lee Kwan-Young , Jang Jong Hyun , Park Hee-Young
Published: January 2024

Polymer electrolyte membrane fuel cells (PEMFCs) are green energy conversion devices, for which commercial markets have been established, owing to their application in fuel cell vehicles (FCVs). Development of cathode electrocatalysts, replacing commercial Pt/C, plays a crucial role in factors such as cost reduction, high performance, and durability in FCVs. PtNi octahedral catalysts are promising for oxygen reduction reactions owing to their significantly higher mass activity (10–15 times) than that of Pt/C; however, their application in membrane electrode assemblies (MEAs) is challenged by their low stability. To overcome this durability issue, various approaches, such as third-metal doping, composition control, halide treatment, formation of a Pt layer, annealing treatment, and size control, have been explored and have shown promising improvements in stability in rotating disk electrode (RDE) testing. In this review, we aimed to compare the features of each strategy in terms of enhancing stability by introducing a stability improvement factor for a direct and reasonable comparison. The limitations of each strategy for enhancing stability of PtNi octahedral are also described. This review can serve as a valuable guide for the development of strategies to enhance the durability of octahedral PtNi.
Diseño de cápsulas digitales por estudiantes de pedagogía bajo modelo ADDIE y metodología A+S
Authors: Villegas Dianta Adrián , Sepúlveda-Irribarra Cristian , Castillo-Paredes Antonio , Núñez-Valdés Karen
Published: January 2024

A partir de la experiencia de creación de cápsulas digitales web, basadas en el modelo ADIEE en una asignatura cuya metodología era el Aprendizaje + Servicio, este estudio se propone explorar la percepción sobre la adquisición de aprendizajes de un grupo de estudiantes de pedagogía a partir de la creación de estas. La metodología empleada fue bajo el enfoque mixto cuali-cuantitativa, con alcance exploratorio. Se utilizó como instrumento un cuestionario semiestructurado, el que fue aplicado en formato online a 68 estudiantes. Como principales resultados se evidenció que la construcción de cápsulas permite desarrollar habilidades digitales en los estudiantes que son transferibles, mientras que la metodología de Aprendizaje+Servicio es valorada, ya que permite contextualizar y recibir retroalimentación directa. Se concluye que existe la necesidad de desarrollar habilidades tecnológicas en los estudiantes de pedagogía para así resolver problemas en el sistema escolar, a partir del contacto directo en el proceso de formación inicial.
PENGARUH SPIRITUAL LEADERSHIP TERHADAP KINERJA, ORGANIZATIONAL BASED SELF-ESTEEM SEBAGAI VARIABEL INTERVENING
Authors: Khafid Abdul , Astuti Fitria Yuni
Published: January 2024

This study aims to analyze the role of Organizational Based Self Esteem (OBSE) in mediating the influence of Spiritual Leadership on the HR Performance of the Sun Life Syariah Insurance Agency team Al Fateeh Semarang. A sample of 102 employees. The sample selection method used in this study is purposive sampling method, namely sampling with techniques adapted to research objectives where the samples used have certain criteria determined based on their positions consisting of Agency Directors, Senior Agency Managers, Agency Managers and Financial Advisors. . The data collection method used in this study was by giving a questionnaire. Data analysis techniques This study uses the SEM-PLS analysis method. Organizational research results provide a positive and influential role in mediating the effect of Spiritual Leadership on Performance. Spiritual leadership influences performance. Organizational Based Self Esteem influences performance.
Mediasi Return On Equity Pengaruh Struktur Modal Terhadap Harga Saham
Authors: Waskito Meindro , Sunaryo Sunaryo , Nurulhuda Elly Soraya , Affar Muhammad
Published: January 2024

Harga saham perubahannya ditentukan oleh ROE (Return on Equity), sedangkan ROE itu sendiri naik turunnya ditentukan oleh struktur modal, maka tujuan dari penelitian ini untuk mengevaluasi pengaruh Struktur Modal terhadap Harga Saham dengan mediasi ROE (Return on Equity). Sampel sebanyak 16 saham yang dipilih dari 27 saham Sub Sektor Perdagangan Eceren yang terdaftar di Bursa Efek Indonesia (BEI) periode tahun 2015-2020 dengan metode purposive sampling. Metode analisis digunakan dengan regresi data panel random effect dengan Path Analysis. Hasil penelitian menunjukan Struktur Modal berpengaruh negatif signifikan terhadap Harga Saham, Struktur Modal berpengaruh positif signifikan terhadap Harga Saham dengan mediasi ROE. Penelitian ini merupakan pengembangan yang mengeksplorasi analisis yang melibatkan variabel mediasi ROE untuk melihat pengaruh struktur modal dengan harga saham dalam lingkup Sub Sektor Perdagangan Eceran di Bursa Efek Indonesia, sehingga dapat memberikan tambahan referensi secara akademis. Secara praktis, hasil penelitian ini dapat memberikan manfaat bagi investor yang berinvestasi di pasar modal.
EFEK MODERASI BUDAYA ORGANISASI TERHADAP KINERJA PEGAWAI BERBASIS TEKNOLOGI INFORMASI DAN PELATIHAN
Authors: Setyawan Joko , Muliadi Dedi
Published: January 2024

Penelitian ini bertujuan untuk menganalisis pengaruh pelatihan terhadap kinerja pegawai, dan teknologi informasi terhadap kinerja pegawai, serta menganalisis budaya organisasi sebagai moderasi pengaruh pelatihan dan teknologi informasi terhadap kinerja pegawai, dengan adanya permasalahan penurunan kinerja pegawai yang terjadi pada salah satu BUMD Kabupaten Kendal. Unit analisis penelitian adalah pegawai salah satu BUMD Kabupaten Kendal. Pengumpulan data dilakukan dengan cara membagikan kuesioner, dengan jumlah responden sebanyak 79 pegawai. Metode analisis yang digunakan dalam menguji hipotesis adalah Structural Equation Modeling (SEM) dengan menggunakan SmartPLS. Hasil dalam penelitian ini menunjukkan bahwa terdapat pengaruh yang positif dan signifikan antara pelatihan dan teknologi informasi terhadap kinerja pegawai. Adapun budaya organisasi dapat menjadi moderasi pengaruh pelatihan terhadap kinerja pegawai, namun budaya organisasi tidak dapat menjadi moderasi pengaruh teknologi informasi terhadap kinerja pegawai.
Recomendaciones y consideraciones para la evaluación de la pérdida auditiva por exposición a ruido recreacional.
Authors: Gilbert Hernández Natalia
Published: January 2024

La exposición a sonidos o ruidos intensos pueden resultar en un cambio de umbral de forma temporal (TTS por sus siglas en inglés), o causar un cambio de umbral permanente (PTS por sus siglas en inglés). La visión común postula que se produce un daño o disfunción por exposición a ruido en las células ciliadas de la cóclea, sin embargo, existen nuevos hallazgos a considerar sobre la fisiopatología del daño auditivo por exposición a ruido que debemos tener presentes al evaluar las consecuencias en población joven.
Los Centros para el Control y la Prevención de Enfermedades de los EE. UU. abordan el daño auditivo causado por el ruido recreacional.
Authors: Eichwald John
Published: January 2024

Durante  cinco  décadas,  los  Centros  para  el  Control  y  la  Prevención  de Enfermedades  (CDC)  han  investigado  la  pérdida  auditiva  inducida  por  el  ruido (NIHL, por sus siglas en inglés) en el lugar de trabajo y han divulgado sus hallazgos a través del Instituto Nacional para la Seguridad y Salud Ocupacional (NIOSH, por sus siglas en inglés). En febrero del 2017, un grupo de trabajo perteneciente al Centro Nacional de Salud Ambiental (NCEH, por sus siglas en inglés), lanzó una campaña sobre la pérdida auditiva con el fin de aumentar la conciencia de que la exposición excesiva  a  sonidos  fuertes  fuera  del  entorno  laboral  puede  provocar  la  pérdida auditiva permanente.
Aplicando la jerarquía del control de riesgos para regular el nivel de ruido en lugares de entretenimiento.
Authors: Mulder Johannes
Published: January 2024

Los niveles de sonido excesivos en eventos dónde la música amplificada es un elemento central representan un riesgo para la audición. Mientras que la exposición al ruido en el lugar de trabajo se ha reconocido como un peligro durante más de un siglo, el daño potencial resultante de la exposición al sonido recreativo sólo se ha hecho evidente en las últimas décadas. En entornos ocupacionales dónde los niveles de ruido son altos, los empleadores deben implementar estrategias de mitigación de riesgos para reducir la exposición al ruido y proteger a los empleados de  acuerdo  con  la  jerarquía  de  controles.  En  principio,  este  mismo  enfoque  de gestión de riesgos se puede
Diagnóstico del estado de bienestar animal en el bioterio de producción de ratones de la cepa CF-1 del Instituto de Salud Pública de Chile
Authors: Ramírez Rodriguez Isaac , Sanhueza Contreras María Jesús , Risso Aguilar Soledad , López Gomez Claudia , Mezzano Oyarce Marcelo
Published: January 2024

El Instituto de Salud Pública de Chile, es el laboratorio de excelencia del Estado de Chile, es la entidad de referencia nacional en los ámbitos de la microbiología, inmunología, bromatología, farmacología, laboratorio clínico, contaminación ambiental y salud ocupacional. Cuenta con 6 departamentos, siendo uno de ellos el Departamento Nacional y de Referencia en Salud Ambiental, en el cual se encuentra el Subdepartamento de Producción de Insumos Especiales para Laboratorio, encargado del Centro Productor de Animales de Laboratorio (CPAL). La Sección CPAL se divide en dos Unidades: Bioterio Chena y Bioterio Santiago, en esta última se encuentra la producción de ratones de laboratorio cepa CF-1, animales que son enviados a los SEREMIS de Salud y clientes internos del ISP para la detección de marea roja (Toxina diarreica) en moluscos bivalvos, principalmente. Este bioterio es el más grande a nivel nacional, con capacidad de abastecer a todas las entidades públicas y privadas que requieren ratones de laboratorio de la cepa CF-1.En este estudio se muestrearon 303 animales (202 hembras y 101 machos). Durante tres semanas se realizaron observaciones antes y después del cambio a jaula limpia con el objetivo de detectar parámetros de estrés y/o dolor. Se adaptó tabla de Morton y Griffiths con el fin de optimizar la observación de los animales y facilitar el análisis de los resultados, considerando que la muestra fue de una gran cantidad de animales.La aplicación de estas tablas modificadas a partir de las de Morton y Griffiths, permitieron identificar la baja tasa de factores estresantes y/o dolor, presentados en los ratones (11%) del total de la muestra.