bluuebunny/crossref_metadata_2025 huggingface dataset:
Modifikasi Penaksir Robust dalam Pelabelan Outlier Multivariat
Authors: Herdiani Erna Tri
Published: December 2018

Outlier adalah suatu observasi yang polanya tidak mengikuti mayoritas data. Outlier dalam kasus multivariat sangat sulit untuk dideteksi, khususnya ketika dimensi lebih dari 2. Kesulitan ini meningkat ketika data set berukuran besar, yakni jumlah variabel menjadi besar. Metode-metode pendeteksian outlier telah lama berkembang dan beberapa digunakan untuk pelabelan outlier sehingga data dapat dipisahkan antara data yang dicurigai sebagai outlier dan data set pada umumnya. Metode-metode tersebut adalah minimum volume ellipsoid disingkat MVE, minimun covariance determinant disingkat MCD, dan minimum vector variance disingkat MVV. Dari ketiga metode tersebut MVV memiliki waktu perhitungan yang paling cepat. Berdasarkan algoritma MVV, kriteria mengurutkan data menggunakan jarak mahalanobis, maka pada paper ini akan dimodifikasi kriteria pengurutan data dengan menghindari penulisan dalam bentuk invers dari matriks variansi kovariansi. Hasil yang diperoleh adalah metode MVV menjadi lebih cepat dengan menggunakan kriteria baru dengan kecermatan yang sama dengan MVV sebelumnya serta akan diaplikan untuk data real dan data simulasi.
Pendekatan Pemrograman Linier untuk Menyelesaikan Masalah Farm Planning
Authors: Rachmawati Ramya , Yosmar Siska
Published: December 2018

Pemrograman Linier merupakan pendekatan yang efektif untuk menyelesaikan masalah optimasi pengalokasian sumber daya yang terbatas. Dari berbagai literatur, dapat diketahui bahwa pendekatan ini telah sukses diterapkan di berbagai bidang, termasuk bidang pertanian dan peternakan. Penelitian ini mengembangkan sebuah model Pemrograman Linier tentang bagaimana seorang manajer yang bergerak di bidang pertanian/peternakan dapat mengelola lahan dan komoditas ternak sapi yang tersedia sehingga menghasilkan keuntungan yang maksimum selama periode waktu perencanaan. Simulasi model dalam penelitian ini dilakukan dengan menggunakan bahasa pemrograman Python 2.7 dan PuLP modeller.
Perbandingan Bagan Kendali Modifikasi Shewhart dan Bagan Kendali ARMAST pada ARMA(1,1)
Authors: Syarifuddin Syandriana , Herdiana Erna Tri , AF M. Saleh
Published: December 2018

Pada umumnya asumsi dasar untuk data pada bagan kendali adalah bersifat saling bebas dan menyebar normal. Namun tidak semua data dapat memenuhi asumsi tersebut salah satunya ketika terjadi autokorelasi. Jika terdapat autokorelasi pada data dapat mempengaruhi tingkat alarm palsu sehingga permasalahan autokorelasi perlu untuk diatasi. Cara untuk mengatasi data berautokorelasi pada bagan kendali dapat dilakukan dengan menggunakan bagan kendali modifikasi Shewhart dan bagan kendali ARMAST. Hasil penelitian menunjukkan pada bagan kendali ARMAST lebih sensitif terhadap data yang out of control dibandingkan dengan bagan kendali modifikasi Shewhart karena nilai ARL yang diperoleh pada bagan kendali ARMAST lebih kecil dibandingkan dengan ARL pada bagan kendali modifikasi Shewhart. Sehingga dalam penelitian ini disimpulkan bahwa performance bagan kendali ARMAST lebih baik dibandingkan bagan kendali modifikasi Shewhart.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KESERINGAN MAHASISWA UNHAS MENGIKUTI PROGRAM GUMSB (GERAKAN UNHAS MENGAJI DAN SHOLAT BERJAMAAH) DENGAN MODEL REGRESI LOGISTIK
Authors: Sari Suci Barlian , Mukhtar Nurhardianti , Cendrah kasih Iis , Anisa Anisa
Published: December 2018

Mahasiswa merupakan bagian yang memegang peranan penting dalam suatu bangsa. Secara umum mahasiswa menyandang tiga fungsi strategis, yaitu sebagai penyampai kebenaran (agent of social control), sebagai agen perubahan (agent of change), dan sebagai generasi penerus masa depan (iron stock). Namun, pada kenyataannya tidak semua mahasiswa dapat menjalankan fungsinya dengan benar. Masih terdapat banyak mahasiswa yang terlibat kasus kriminal seperti perkelahian, tawuran, pencurian, pembunuhan terhadap dosen, penyalahgunaan narkotika, penipuan, perusakan, dan masih banyak tindakan kriminal lainnya. Berangkat dari kondisi akhlak mahasiswa yang buruk  membuat pihak birokrasi unhas prihatin, sehingga pihak birokrasi unhas bekerjasama dengan Asosisasi masjid Kampus Indonesia (AMKI) berinisiatif membuat suatu program “Gerakan Unhas Mengaji dan Sholat Berjamaah (GUMSB)”. Tujuan dari penelitian ini adalah untuk mengukur dampak dari GUMSB terhadap minat baca Al-Quran Mahasiswa Unhas dengan model regresi logistik. Analisis pada model regresi logistik digunakan untuk mendeskripsikan hubungan antar variabel terikat yang memiliki dua kategori atau lebih. Variabel terikat pada penelitian ini yaitu keseringan mahasiswa mengikuti GUMSB, dimana kategori yang digunakan pada variabel terikat ini adalah 1 untuk yang sering dan 0 untuk yang jarang mengikuti GUMSB. Sedangkan variabel prediktor yang digunakan adalah semangat dan minat dalam mempelajari Al-Quran dan Organisasi.. hasil dari penelitian ini adalah variable bebas semangat dan minat membaca Al-Quran dan organisasi  semuanya mempengaruhi minat baca Al-Quran mahasiswa unhas secara signifikan.  Adapun bentuk logit dari model akhir adalah :gˆ (x) = -5,763 + 1,229 * semangat dan minat dalam mempelajari Al-Quran + 1,004 *organisasi.
PERAMALAN JUMLAH PENDERITA DEMAM BERDARAH DENGUE DI KABUPATEN JOMBANG JAWA TIMUR DENGAN PENDEKATAN FUNGSI TRANSFER SINGLE INPUT
Authors: Sediono Sediono
Published: December 2018

Peramalan adalah sesuatu hal yang penting dalam analisis runtun waktu, karena dengan diperolehnya sebuah model yang tepat secara statistik, jelas hal tersebut dapat digunakan untuk memprediksi struktur pola data yang akan datang. Fungsi transfer merupakan salah satu model matematis dalam analisis runtun waktu  yang dapat digunakan untuk  peramalan data indeks waktu baik univariat maupun multivariat. Fungsi transfer menggambarkan nilai prediksi  dari  output series (Yt) berdasarkan nilai satu atau lebih input series (Xt). Model fungsi transfer  single input  adalah model fungsi transfer yang menggunakan satu variabel sebagai input series (Xt), dimana masing-masing series baik input series maupun output series keduanya harus sama-sama merupakan model runtun waktu yang stasioner, baik stasioner dalam mean maupun stasioner dalam varian. Salah satu penggunaan  model fungsi transfer ini adalah untuk pembuatan model dan peramalan jumlah kasus demam berdarah dengue (Yt)  di Kabupaten Jombang Jawa Timur, dengan variabel inputnya berdasarkan data curah hujan (Xt). Dari hasil penelitian diperoleh  model fungsi transfer yang memiliki persamaan  Y𝑡 = 0,0542X𝑡 +  (1 − 0,7309𝐵)(1 + 0,6568𝐵12) 𝑎𝑡 , dengan parameter ωo = 0,0542, ∅1 = 0,7309, dan Φ12 = -0,6568. Dari model tersebut dapat diinterpretasikan bahwa jumlah penderita demam berdarah dengue pada suatu bulan dipengaruhi curah hujan pada bulan itu, dan dipengaruhi oleh beberapa gangguan pada bulan-bulan sebelumnya. Selanjutnya berdasarkan model fungsi transfer tersebut dapat digunakan untuk peramalan jumlah penderita demam berdarah dengue di Kabupaten Jombang untuk periode 20 bulan kedepan. Setelah dilakukan perbandingan antara data hasil peramalan dengan data aktual, terdapat kesamaan trend yaitu sejumlah 15 bulan dari 20 bulan yang diramalkan, sehingga dapat dijelaskan bahwa sebagian besar yaitu 75% dari hasil peramalan  dalam penelitian ini adalah valid.
Roux-en-Why? What the Orthopaedic Surgeon Needs to Know About Bariatric Surgery
Authors: Cohen-Rosenblum Anna , Kew Michelle E. , Johnson-Mann Crystal , Browne James A.
Published: December 2018

* Bariatric surgical procedures can be subdivided into restrictive, malabsorptive, and restrictive and malabsorptive categories.

* The greatest amount of excess weight loss occurs by 18 to 24 months following these procedures and can exceed 70% in certain procedures.

* Postoperative malabsorption of fat-soluble vitamins and protein is most common in patients with combined restrictive and malabsorptive procedures such as biliopancreatic diversion.

* Patients undergoing a bariatric surgical procedure are at an increased risk of fracture due to changes in bone metabolism, with the potential risk for decreased fracture-healing that has not been extensively studied.

* Regardless of the improvement in body mass index, patients undergoing a bariatric surgical procedure appear to remain at higher risk for complications with total joint arthroplasty when compared with the general population.
Specific Features of Heatand Mass Transfer Processes in Road Dressings
Authors: Khroustalev B. M. , Liu Tingguo , Akeliev V. D. , Aliakseyeu Yu. H. , Shi Jicun , Zankovich V. V.
Published: December 2018

The paper presents a fragment of on-going investigations directed on creation of optimum data environment that ensures an access to world scientific journals and other publications which are necessary for qualitative implementation of works on priority directions of R&D in the field of road-construction industry in the period of 2016–2020. A citation analysis has been applied while using data of Journal Citation Reports for selection of world scientific serial publiccations which are necessary for execution of investigations on heat and mass transfer in road dressings. The road dressings are considered as open heterogeneous thermodynamic systems. Their deformations occur under various climatic conditions due to heat and mass transfer processes and interaction of transport flows and road surface. Crack formation takes place in depth of the road dressings and on road surfaces as a result of temperature, mass transfer processes. As it is known material structure of constructive layers especially which are created with the help of technogenic wastes (asphalt-concrete, concrete, reinforced concrete scrap and products of its recycling, brick rubble, various wastes of production etc.) influence on heat and mass transfer. The paper presents results of investigations on heat flows, boundary layers according to air viscosity, velocity of geometric permeability characteristics, capillary pressures in road pavements.
35 años de carteles turísticos en Cataluña: evolución de la imagen turística catalana del 1980 al 2015
Authors: Descamps Gemma , Camprubí Raquel
Published: December 2018

Este artículo analiza la imagen turística de Cataluña a través de los carteles turísticos que se han publicado desde el año 1980 hasta la actualidad, con el fin de determinar los cambios producidos en las características y atributos promocionados del destino desde un punto de vista cronológico. Para ello se han analizado un total de 192 carteles mediante análisis de contenido. Los resultados apuntan una clara evolución de la imagen turística de Cataluña a lo largo del tiempo, con cambios substanciales en cada una de las etapas considerando los distintos factores analizados.
Patrón de distribución espacial de especies de Quercus y formaciones de encinos en Tamaulipas (México)
Authors: Morales Pacheco Juan Francisco , Camara Artigas Rafael , Requena Lara Glenda Nelly , Lara Villalon Manuel , García Morales Leccinum Jesús
Published: December 2018

Se describen los Patrones de Distribución Espacial de las formaciones de encinos en el estado de Tamaulipas, México, a partir de los factores bioclimáticos y litológicos. Para lo anterior se utilizó el Método de Regímenes Ecodinámicos a través de un análisis espacial en un Sistema de  Información Geográfico (SIG) con verificación en campo. Se analizaron los patrones de distribución de las formaciones vegetales de encinos: bosque mixto, bosque de encino, chaparral y bosque húmedo montano. Se presentan mapas de distribución de cada formacion vegetal en función del su bioclima y litología. Los modelos generados arrojan cinco tipos principales de regímenes para las formaciones de encinos (Critropófilo, Euritermo-tropófilo, Euritermo-mesófilo Mesófilo-subhúmedo y Tropófilo). Los resultados anteriores permiten hacer un diagnóstico ecológico a fin de poder establecer propuestas de conservación de las áreas con una mayor diversidad de Quercus en la región.
Influencia térmica antrópica local y global en el observatorio Fabra para el periodo 1924–2016
Authors: Barros Pozo Patricia Magaly , Martín-Vide Javier
Published: December 2018

Se presenta una primera aproximación en la diferenciación de la contribución local y global en el incremento de la temperatura del aire en Barcelona. Para ello, se busca determinar la influencia local del área metropolitana de Barcelona en el aumento de la temperatura del aire registrado en el observatorio Fabra, para el periodo 1924–2016, a diferencia del observatorio del Ebro (observatorio de referencia) que presenta solamente la influencia del calentamiento global por ubicarse en una zona rural. La temperatura registrada en el observatorio Fabra presentó una tendencia significativa al incremento durante 1924–2016, incrementándose la temperatura media anual en 1,26 °C. Durante el subperiodo 1972–2016, la temperatura registró una tasa más acelerada en comparación con el subperiodo 1924–1971, coincidiendo el primer subperiodo con los años en que las investigaciones sobre el cambio climático muestran resultados más concluyentes de la influencia antropogénica en el aumento de la temperatura del aire. Considerando dicho subperiodo, el observatorio Fabra registró una influencia térmica local del área metropolitana de Barcelona de 0,0073 °C/año en la temperatura media anual, mientras que 0,0386 °C/año correspondió al aporte del calentamiento global, registrado en el observatorio del Ebro.
Cincuenta años de la Geografía Regional de España, obra universitaria, de escuela y de época (1968–2018)
Authors: Gómez Mendoza Josefina
Published: December 2018

El texto conmemora los cincuenta años de la primera Geografía regional de España, concebida como una obra de la escuela geográfica española para ser un libro de texto para estudiantes universitarios, y libro de consulta para otros científicos afines y lectores cultos. La obra está dirigida por los dos grandes maestros de la geografía del siglo XX, Lluis Solé Sabarís, catedrático catalán de geografía física y Manuel de Terán, geógrafo humano de Madrid y en ella participan autores de distintas universidades españolas. Se estudia cómo fue posible el libro, la adopción que hace del método regional de la escuela francesa de geografía, entonces dominante, sus aciertos y limitaciones, así como la opción que hace importante que optara por la división en regiones históricas, solo levemente corregidas. También se considera en qué medida la obra traduce los grandes cambios demográficos y territoriales que se produjeron en la segunda mitad del siglo XX. Se concluye que, por ser un libro de texto universitario, resultado del trabajo conjunto de geógrafos de las diversas partes de España, y perteneciente a un momento de transformación del país, es uno de los libros que han hecho época en la geografía española.
Carbon Capture, Utilization, and Storage: An Update
Authors: Orr Franklin M.
Published: December 2018

Recent progress in carbon capture, utilization, and storage (CCUS) is reviewed. Considerable research effort has gone into carbon dioxide (CO2) capture, with many promising separation processes in various stages of development, but only a few have been tested at commercial scale, and considerable additional development will be required to determine competitiveness of new technologies. Processes for direct capture of CO2 from the air are also under development and are starting to be tested at pilot scale. Transportation of CO2 to storage sites by pipeline is well-established, though substantially more pipeline capacity will be required if CCUS is to be undertaken at a large scale. Considerable experience has now been built up in enhanced-oil-recovery (EOR) operations, which have been under way since the 1970s. Storage in deep saline aquifers has also been achieved at scale. Recent large-scale projects that capture and store CO2 are described, as are current and potential future markets for CO2. Potential effects of changes in the US tax code Section 45Q on those markets are summarized. Future deployment of CCUS will depend more on cost reductions for CO2 separations, development of new markets for CO2, and the complexities of project finance than on technical issues associated with storage of CO2 in the subsurface.
An evaluation of a public relations program in promoting synergistic cooperation between schools and industries
Authors: Aw Suranto
Published: December 2018

This evaluation study responds to the need for public relations (PR) as a management function in building and maintaining reciprocal relationships between schools and industries that are increasing dramatically. The rapid development of public relations in Indonesia is influenced by socio-cultural changes in Indonesian society, which cannot be separated from the high intensity of national development. This evaluation research aims to compare the actual implementation of a PR program to its intended objectives in promoting cooperation between schools and industries. This study used the Discrepancy Evaluation Model (DEM) with four systematic stages: (1) definition, (2) installation, (3) process, and (4) product. The finding shows that there is no discrepancy between the program’s actual implementation and its predetermined objectives. The program implementation has met the criteria of success in achieving proposed goals (good category) and the program operates as it was planned. The program aimed to foster successful collaboration between schools and industries. The scope of the partnership includes information sharing for the purposes of curriculum development, student apprenticeship and competency tests.
Seasonal changes of the concentrations of mineral forms of nitrogen and phosphorus in watercourses in the agricultural catchment area (Bay of Puck, Baltic Sea, Poland)
Authors: Wojciechowska E. , Nawrot N. , Matej-Łukowicz K. , Gajewska M. , Obarska-Pempkowiak H.
Published: December 2018

The Baltic Region countries are obliged to meet the stringent limits of N and P discharge set by HELCOM for 2021. Area sources of pollution, including agriculture, are considered the main contributors of biogenic compounds. The Bay of Puck as an inner part of the Baltic Sea is particularly sensitive to eutrophication caused by nutrient inflow from agricultural lands. Rivers and streams inflowing to the Bay of Puck transport nitrogen and phosphorus compounds washed out from fields. The article discusses concentrations of nitrogen and phosphorus compounds measured during annual research (VII.2017 – VI.2018) at three watercourses: Płutnica, Reda and Błądzikowski Stream inflowing to the Bay of Puck. The concentrations ranged from 0.01 to 0.13 mg/L N-NO2, from 0.39 to 7.55 mg/L N-NO3, from 0.03 to 0.58 mg/L N-NH4, from 0.44 to 9.51 mg/L TN, from 0.05 to 0.45 mg/L P-PO4 and from 0.03 to 1.89 mg/L TP. Seasonal changes of nutrient concentrations were observed, with maximum concentrations of nitrates in August and September after application of fertilizers to arable land.
Mapping Mimotopes for House Dust Mite Allergen Der f 7 Using a Specific Monoclonal Antibody
Authors: Peng Jianglong , Yin Hao , Zhou Ying , Jia Haoyuan , Cui Yubao
Published: December 2018

Background:

The dust mite Dermatophagoides farinae is a common worldwide cause of indoor allergies induced by its proteins, including the mid-tier allergen Der f 7.  Objective: To identify conformational epitopes in Der f 7 using mimotope mapping and computational modelling.

Methods:

Here, we used standard hybridoma technology to generate 3 new monoclonal antibodies against Der f 7 and performed mimotope mapping by probing a random peptide phage display library. Computational tools, including Minox and the DiscoTope-2.0 Server were used to assess the structure and potential position of antigenic residues within Der f 7.

Results:

Thirteen mimotopes sharing the common sequence --XX[LST]P[-E][LI]MLPLR[-S]- were identified. Further, computationally-predicted conformational epitopes were found at residues 1-7, 10, 27, 76-81, 92, and 130-133 of Der f 7, and the key amino acids for these epitopes were deduced to be 2P, 3I, 10E, 27E, 78E, 79E, 81I, 130S, and 132E based on the common mimotope sequence.

Conclusion:

We identified Der f 7 peptide mimotopes that may model binding sites for blocking antibodies. These may guide the development of immunotherapy for individuals with hypersensitivity to Der f 7.
Leucine Rich Repeat Proteins: Sequences, Mutations, Structures and Diseases
Authors: Matsushima Norio , Takatsuka Shintaro , Miyashita Hiroki , Kretsinger Robert H.
Published: December 2018

Mutations in the genes encoding Leucine Rich Repeat (LRR) containing proteins are associated with over sixty human diseases; these include high myopia, mitochondrial encephalomyopathy, and Crohn’s disease. These mutations occur frequently within the LRR domains and within the regions that shield the hydrophobic core of the LRR domain. The amino acid sequences of fifty-five LRR proteins have been published. They include Nod-Like Receptors (NLRs) such as NLRP1, NLRP3, NLRP14, and Nod-2, Small Leucine Rich Repeat Proteoglycans (SLRPs) such as keratocan, lumican, fibromodulin, PRELP, biglycan, and nyctalopin, and F-box/LRR-repeat proteins such as FBXL2, FBXL4, and FBXL12. For example, 363 missense mutations have been identified. Replacement of arginine, proline, or cysteine by another amino acid, or the reverse, is frequently observed. The diverse effects of the mutations are discussed based on the known structures of LRR proteins. These mutations influence protein folding, aggregation, oligomerization, stability, protein-ligand interactions, disulfide bond formation, and glycosylation. Most of the mutations cause loss of function and a few, gain of function.
Design, Synthesis and Therapeutic Potential of Some 6, 6'-(1,4- phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues
Authors: Kumar Sanjiv , Narasimhan Balasubramanian , Lim Siong Meng , Ramasamy Kalavathy , Mani Vasudevan , Shah Syed Adnan Ali
Published: December 2018

Background: A series of 6, 6'-(1,4-phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)
derivatives has been synthesized by Claisen-Schmidt condensation and its chemical structures was
confirmed by FT-IR, 1H/13C-NMR spectral and elemental analyses. The molecular docking study was
carried out to find the interaction between active bis-pyrimidine compounds with CDK-8 protein. The
in vitro antimicrobial potential of the synthesized compounds was determined against Gram-positive
and Gram-negative bacterial species as well fungal species by tube dilution technique. Antimicrobial
results indicated that compound 11y was found to be most potent one against E. coli (MICec = 0.67
µmol/mL) and C. albicans (MICca = 0.17 µmol/mL) and its activity was comparable to norfloxacin
(MIC = 0.47 µmol/mL) and fluconazole (MIC = 0.50 µmol/mL), respectively.

Conclusion:

Anticancer screening of the synthesized compounds using Sulforhodamine B (SRB) assay
demonstrated that compounds 2y (IC50 = 0.01 µmol/mL) and 4y (IC50= 0.02 µmol/mL) have high antiproliferative
potential against human colorectal carcinoma cancer cell line than the reference drug (5-
fluorouracil) and these compounds also showed best dock score with better potency within the ATP
binding pocket and may also be used lead for rational drug designing.
Changes in Scaphoid and Lunate Position and Loading at Two Wrist Pushup Positions
Authors: Werner Frederick W. , Tucci Emily R. , Daly Brett T. , Harley Brian J.
Published: December 2018

Background:

Scapholunate interosseous ligament (SLIL) injury following a fall on an
outstretched hand may lead to carpal instability and in some cases require long-term rehabilitation
following repair. Rehabilitation, especially in athletes, may include pushups, but little is known as
to what type of pushup may be safer.

Objective:

To determine biomechanical differences between two pushup positions (neutral or extended).

Methods:

Six fresh cadaver wrists with pre-existing SLIL damage were uni-axially loaded in neutral
and extension in order to simulate two different pushup styles. The motions of the scaphoid and
lunate in relation to the radius were measured. The dorsal, proximal, and volar insertion sites of the
SLIL were identified and, using the collected kinematic data, gap distances were calculated for
each site.

Conclusion:

The larger gap distances between the scaphoid and lunate in neutral suggest that a
neutral style pushup could put higher forces on a wrist with pre-existing SLIL damage and may
thus hinder recovery for a person with a repaired SLIL. A pushup in extension, in these injured
wrists, may be less detrimental.
DPP-IV Inhibitory Phenanthridines: Ligand, Structure-Based Design and Synthesis
Authors: Khalaf Reema A. , Masalha Dalal , Sabbah Dima
Published: December 2018

Background:

Lately, diabetes has become the main health concern for millions of people around
the world. Dipeptidyl peptidase-IV (DPP-IV) inhibitors have emerged as a new class of oral antidiabetic
agents. Formerly, acridines, N4-sulfonamido-succinamic, phthalamic, acrylic and benzoyl acetic acid derivatives,
and sulfamoyl-phenyl acid esters were designed and developed as new DPP-IV inhibitors.

Objective:

This study aims to develop a pharmacophore model of DPP-IV inhibitors and to evaluate phenanthridines
as a novel scaffold for inhibiting DPP-IV enzyme. In addition, to assess their binding interactions
with the enzyme through docking in the binding site of 4A5S (PDB).

Methods:

Herein, Quantum–Polarized Ligand Docking (QPLD) and ligand-based pharmacophore modeling
investigations were performed. Three novel 3,8-disubstituted-6-phenyl phenanthridine derivatives 3-5 have
been designed, synthesized and characterized. In vitro biological testing against DPP-IV was carried out using
fluorometric assay kit.

Results:

QPLD study demonstrates that compounds 3-5 forms H-bond with Lys554, Trp629, and Tyr631,
besides charge transfer interaction between their aromatic rings and the aromatic rings of Tyr547 and
Tyr666. Moreover, they fit the three pharmacophoric point features of DPP-IV inhibitors and were proven
to have in vitro DPP-IV inhibitory activity where compound 5 displayed a % inhibition of 45.4 at 100 μM
concentration.

Conclusion:

Phenanthridines may serve as a potential lead compound for developing new DPP-IV inhibitors
as a promising antidiabetic agent. Computational results suggest future structural simplification.
Social Media Content About Children’s Pain and Sleep: Content and Network Analysis (Preprint)
Authors: Tougas Michelle E , Chambers Christine T , Corkum Penny , Robillard Julie M , Gruzd Anatoliy , Howard Vivian , Kampen Andrea , Boerner Katelynn E , Hundert Amos S
Published: December 2018

BACKGROUND

Social media is often used for health communication and can facilitate fast information exchange. Despite its increasing use, little is known about child health information sharing and engagement over social media.

OBJECTIVE

The primary objectives of this study are to systematically describe the content of social media posts about child pain and sleep and identify the level of research evidence in these posts. The secondary objective is to examine user engagement with information shared over social media.

METHODS

Twitter, Instagram, and Facebook were searched by members of the research team over a 2-week period using a comprehensive search strategy. Codes were used to categorize the content of posts to identify the frequency of content categories shared over social media platforms. Posts were evaluated by content experts to determine the frequency of posts consistent with existing research evidence. User engagement was analyzed using Netlytic, a social network analysis program, to examine visual networks illustrating the level of user engagement.

RESULTS

From the 2-week period, nearly 1500 pain-related and 3800 sleep-related posts were identified and analyzed. Twitter was used most often to share knowledge about child pain (639/1133, 56.40% of posts), and personal experiences for child sleep (2255/3008, 75.00% of posts). For both topics, Instagram posts shared personal experiences (53/68, 78% pain; 413/478, 86.4% sleep), Facebook group posts shared personal experiences (30/49, 61% pain; 230/345, 66.7% sleep) and Facebook pages shared knowledge (68/198, 34.3% pain; 452/1026, 44.05% sleep). Across platforms, research evidence was shared in 21.96% (318/1448) of pain- and 9.16% (445/4857) of sleep-related posts; 5.38% (61/1133) of all pain posts and 2.82% (85/3008) of all sleep posts shared information inconsistent with the evidence, while the rest were absent of evidence. User interactions were indirect, with mostly one-way, rather than reciprocal conversations.

CONCLUSIONS

Social media is commonly used to discuss child health, yet the majority of posts do not contain research evidence, and user engagement is primarily one-way. These findings represent an opportunity to expand engagement through open conversations with credible sources. Research and health care communities can benefit from incorporating specific information about evidence within social media posts to improve communication with the public and empower users to distinguish evidence-based content better. Together, these findings have identified potential gaps in social media communication that may be informative targets to guide future strategies for improving the translation of child health evidence over social media.
Electronic Consultation in Primary Care Between Providers and Patients: Systematic Review (Preprint)
Authors: Mold Freda , Hendy Jane , Lai Yi-Ling , de Lusignan Simon
Published: December 2018

BACKGROUND

Governments and health care providers are keen to find innovative ways to deliver care more efficiently. Interest in electronic consultation (e-consultation) has grown, but the evidence of benefit is uncertain.

OBJECTIVE

This study aimed to assess the evidence of delivering e-consultation using secure email and messaging or video links in primary care.

METHODS

A systematic review was conducted on the use and application of e-consultations in primary care. We searched 7 international databases (MEDLINE, EMBASE, CINAHL, Cochrane Library, PsycINFO, EconLit, and Web of Science; 1999-2017), identifying 52 relevant studies. Papers were screened against a detailed inclusion and exclusion criteria. Independent dual data extraction was conducted and assessed for quality. The resulting evidence was synthesized using thematic analysis.

RESULTS

This review included 57 studies from a range of countries, mainly the United States (n=30) and the United Kingdom (n=13). There were disparities in uptake and utilization toward more use by younger, employed adults. Patient responses to e-consultation were mixed. Patients reported satisfaction with services and improved self-care, communication, and engagement with clinicians. Evidence for the acceptability and ease of use was strong, especially for those with long-term conditions and patients located in remote regions. However, patients were concerned about the privacy and security of their data. For primary health care staff, e-consultation delivers challenges around time management, having the correct technological infrastructure, whether it offers a comparable standard of clinical quality, and whether it improves health outcomes.

CONCLUSIONS

E-consultations may improve aspects of care delivery, but the small scale of many of the studies and low adoption rates leave unanswered questions about usage, quality, cost, and sustainability. We need to improve e-consultation implementation, demonstrate how e-consultations will not increase disparities in access, provide better reassurance to patients about privacy, and incorporate e-consultation as part of a manageable clinical workflow.
Standards for mobile health-related apps (Preprint)
Authors: Miró Jordi , Llorens-Vernet Pere
Published: December 2018

BACKGROUND

In recent years, the considerable increase in the number of mobile health apps has made healthcare more accessible and affordable for all. However, the exponential growth in mHealth solutions has occurred with almost no control or regulation of any kind. Despite some recent initiatives, there is still no specific regulation procedure, accreditation system or standards to help the development of the apps, mitigate risks or guarantee quality.

OBJECTIVE

The main aim of this study is to provide a set of standards for mobile health-related apps on the basis of what is available from guidelines, frameworks, and standards in the field of health app development.

METHODS

To identify the most important criteria, we used three strategies. First, we conducted a systematic review of all the studies published on health-related apps. Second, we searched for health-app recommendations on the websites of professional organizations. Finally, we looked for standards governing the development of software for medical devices on the specialized webs of regulatory organizations. Then, we compiled the criteria we had identified and determined which of them could be regarded as essential, recommendable or desirable.

RESULTS

We identified a total of 168 criteria from the systematic review, 282 criteria from published guidelines, and 53 criteria from the standards of medical devices. These criteria were then grouped and subsumed under 8 categories, which included 36 important criteria for health apps. Of these 7 were considered to be essential, 18 recommendable, and 11 desirable. The more essential criteria an mHealth application has, the greater its quality.

CONCLUSIONS

This set of standards can be easily used by health care providers, developers, patients and other stakeholders, both to guide the development of mHealth related apps and to measure the quality of an mHealth app.
Population-Based Study of Risk of AKI with Levetiracetam
Authors: Yau Kevin , Burneo Jorge G. , Jandoc Racquel , McArthur Eric , Muanda Flory Tsobo , Parikh Chirag R. , Wald Ron , Weir Matthew A. , Garg Amit X.
Published: December 2018

Background and objectives

Regulatory agencies warn about the risk of AKI with levetiracetam use on the basis of information from case reports. We conducted this study to determine whether new levetiracetam use versus nonuse is associated with a higher risk of AKI.

Design, setting, participants, & measurements

This was a population-based retrospective cohort study of adults with epilepsy in Ontario, Canada. Patients who received a new outpatient prescription for levetiracetam between January 1, 2004 and March 1, 2017 were matched to two nonusers on stage of CKD, recorded seizure in the prior 90 days, and logit of a propensity score for levetiracetam use. The primary outcome was a hospital encounter (emergency department visit or hospitalization) with AKI within 30 days of cohort entry. Secondary outcomes were AKI within 180 days and change in the concentration of serum creatinine. We assessed the primary outcome using health care diagnosis codes. We evaluated the change in the concentration of serum creatinine in a subpopulation with laboratory measurements.

Results

We matched 3980 levetiracetam users to 7960 nonusers (mean age 55 years, 51% women). Levetiracetam use was not significantly associated with a higher risk of AKI within 30 days (13 [0.33%] events in levetiracetam users and 21 [0.26%] events in nonusers [odds ratio, 1.24; 95% confidence interval, 0.62 to 2.47]). Similarly, there was no significant association with AKI within 180 days (odds ratio, 0.70; 95% confidence interval, 0.43 to 1.13). The change in the concentration of serum creatinine did not significantly differ between levetiracetam users and nonusers.

Conclusions

In this population-based study levetiracetam use was not associated with a higher risk of AKI.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_12_11_Yau_Podcast.mp3
Nanopartículas de plata biogénicas a partir del hongo Punctularia atropurpurascens para el control de microorganismos
Authors: Sanguiñedo Paula , Estevez María Belén , Faccio Ricardo , Alborés Silvana
Published: December 2018

Las nanopartículas de plata poseen propiedades particulares que le atribuyen sus muy promisorias aplicaciones, novedosas en diversos campos de la ciencia. Una de las principales aplicaciones de las nanopartículas de plata es su actividad antimicrobiana. Las enfermedades infecciosas son aún una de las principales causas de muerte en el mundo. El desarrollo de resistencia a drogas, así como los efectos adversos que ocasionan hacen necesaria la búsqueda de estrategias alternativas para el tratamiento de dichas enfermedades. En el área agrícola, a pesar de las mejoras en la capacidad de diagnóstico y disponibilidad de tecnologías para el control de enfermedades, ellas aún son capaces de causar enormes pérdidas de cosechas. En este sentido, el potencial antimicrobiano de las nanopartículas de plata es muy promisorio.

La síntesis biológica de nanopartículas es de gran interés sobre otros métodos (físicos y químicos) porque se evita el uso de químicos tóxicos y condiciones drásticas de reacción. En el caso de la utilización de microorganismos la síntesis extracelular es ventajosa para la separación y purificación de las nanopartículas. Asimismo es importante el análisis de las condiciones de reacción que permitan una mayor producción de nanopartículas, así como el control del tamaño y la forma.

En el presente trabajo se realizó la síntesis de nanopartículas de plata por extractos provenientes del hongo Punctularia atropurpurascens. Se estudiaron diferentes condiciones de reacción de síntesis y se evaluó el potencial antimicrobiano de las nanopartículas biogénicas frente a microorganismos de interés en las áreas de salud y agroalimentaria.
Computational study of natural convection and entropy generation in 3-D cavity with active lateral walls
Authors: Alnaqi Abdulwahab , Hussein Ahmed , Kolsi Lioua , Al-Rashed Abdullah , Li Dong , Ali Hafiz
Published: December 2018

Numerical simulation of the natural convection and entropy generation in an air-filled cubical cavity with active lateral walls is performed in this work. Both the lateral front and right sidewalls are maintained at an isothermal cold temperature. While an isothermal hot temperature is applied for both the lateral back and left sidewalls. The upper and lower walls are kept adiabatic. Entropy generation rates due to the fluid friction and the heat transfer are simulated by using the Second law of thermodynamics. Results are illustrated for Rayleigh numbers varied from (103 ? Ra ? 106). It was shown that the increase in the Rayleigh number leads to increase the average Nusselt number and to decrease the Bejan number. Also, it was found that both, Sth, and Stot, increase slightly with the increase in Rayleigh number until they reach (Ra = 105) and then begin to jump after this value. After (Ra = 105), the increase in both, Stot, and Sfr, is greater than Sth. Moreover, it was observed that iso-surfaces of Stot are similar to Sth at (103 ? Ra ? 105), while they are similar to Sfr at high Rayleigh number.
Assessment of chemical mechanism and chemical reaction sensitivity analysis for CH4/H2 flame under mild combustion environment
Authors: Yang Zhao , Li Xiangsheng , Wang Zhenlin , Wang Zhuangqi
Published: December 2018

To analyze the performance of different chemical mechanisms on the prediction under moderate and intense low-oxygen dilution combustion environment, six different kinds of mechanisms were tested by solving the Reynolds averaged Navier- Stokes equations in a 2-D domain with the eddy dissipation concept model by FLUENT software. Temperature and the species concentration of OH, CO, and H2O were compared with the experiment data. The experiment results showed some similarities for each chemical mechanism as well as discrepancies. The comparison of CH4 oxidation route between the GRI2.11 and GRI3.0 mechanisms was made by Chemkin code. Reaction 95 and 147 were responsible for low temperature region for GRI2.11 mechanism at downstream area.
A new notion of transitive relative return rate and its applications using stochastic differential equations
Authors: Izgi Burhaneddin
Published: December 2018

We introduce a new notion of transitive relative return rate and present its applications based on the stochastic differential equations. First, we define the notion of a relative return rate and show how to construct the transitive relative return rate (TRRR) on it. Then, we state some propositions and theorems about relative return rate and TRRR and prove them. Moreover, we exhibit the theoretical framework of the generalization of TRRR for 3 n ? cases and prove it, as well. Furthermore, we illustrate our approach with real data applications of daily relative return rates for Borsa Istanbul-30 (BIST-30) and Intel Corporation indexes with respect to daily interest rate of Central Bank of the Republic of Turkey between June 18, 2003 and June 17, 2013. For this purpose, we perform simulations via Milstein method. We succeed to present usefulness of the relative return rate for the relevant real large data set using the numerical solution of the stochastic differential equations. The simulation results show that the proposed closely approximates the real data
Polynomial based differential quadrature for numerical solutions of Kuramoto-Sivashinsky equation
Authors: Yigit Gulsemay , Bayram Mustafa
Published: December 2018

In this study, a numerical discrete derivative technique for solutions of Kuramoto-Sivashinksy equation is considered. According to the procedure, differential quadrature algorithm is adapted in space by using Chebyshev polynomials and explicit scheme is constructed to discretize time derivative. Sample problems are presented to support the idea. Numerical solutions are compared with exact solutions and also previous works. It is observed that the numerical solutions are well matched with the exact or existing solutions.
Simulating chloride penetration in fly ash concrete by a fractal derivative model
Authors: Qu Pengfei , Liu Xiaoting , Baleanu Dumitru
Published: December 2018

In the real engineering field, the chloride ions behave abnormal diffusion phenomena in concrete caused by different compositions of the concrete which lead to the complex physical and chemical properties. This paper utilizes a fractal derivative model and a fractional derivative model to describe the diffusion phenomena. Furthermore, according to actual experimental data in the field, the fractional and fractal model can simulate the diffusion behavior of chloride ions in concrete. In comparison to the fractional derivative model, the fractal derivative model gives a simpler mathematical expression and lower calculation costs. In addition, the linear regression analysis method is used to establish an effective relationship between the internal composition of concrete and the parameters of fractal model such as fractal order, ?, and diffusion coefficient, D. As a result, the fractal model with the parameters estimated by previous relationship can predict the diffusion behavior of chloride ions.
Ensino de repertórios requisitos e os efeitos sobre comportamentos incompatíveis com aprendizagem em crianças com Transtorno do Espectro Autista
Authors: Guerra Barbara Trevizan
Published: December 2018

Pessoas com Transtorno do Espectro Autista (TEA) podem apresentar déficits significativos no repertório básico requisito para receber programas de ensino e se engajar com frequência em comportamentos repetitivos e inadequados. Considerando-se que tais comportamentos são incompatíveis com o ensino e resultam em consequências negativas, sejam sociais e/ou acadêmicas, esta pesquisa teve por objetivo ensinar sistematicamente operantes requisitos, como sentar, permanecer sentado, olhar, imitar, imitação generalizada e rastreamento visual para duas crianças com TEA, e verificar o efeito do procedimento sobre os comportamentos inadequados e estereotipias. Os resultados demonstraram que um participante aprendeu todos os comportamentos alvo de ensino enquanto o outro não atingiu o critério de aprendizagem em imitação. Houve redução dos comportamentos incompatíveis com a aprendizagem, logo após a introdução das contingências para os comportamentos de ensino, para ambos. Os resultados demonstram a aquisição de repertórios requisitos importantes em crianças com TEA severo e demonstram que a redução de comportamentos incompatíveis com aprendizagem pode ocorrer mediante ensino de comportamentos desejados.
STUDI TENTANG PENGGUNAAN PAKAN KOMERSIL YANG DICAMPUR DENGAN BAKTERI Bacillus coagulans TERHADAP PERFORMA Litopenaeus vannamei
Authors: Suri Ratna , Putri Berta , Susanti Oktora
Published: December 2018

In vaname shrimp cultivation, one of the problem that often arise is the high production costs in provision of feed The use of probiotics is a viable alternative to reduce production costs. The probiotic that used in this research was Bacillus coagulans bacteria. This research was aimed to know the effect of the use of Bacillus coagulans bacteria in feed on weight growth, lenght growth, survival rate, feed conversion ratio, and water quality in cultivation on vaname shrimp. Post larvae 10 vaname shrimp as much as 25 pcs were placed in each aquariums with volume 50x40x40 cmfor 30 days. The probiotics with dosage of treatment 30 ml/kg; 50 ml/kg; 70 ml/kg were combined in commercial feed with the protein content 32%. The shrimp feeding method that used in this research was blind feeding with 4 times feeding a day. The result showed that the best treatment was 70 ml/kg feed giving the significant effect on weight growth, length growth, andfeed conversion ratio. The treatments didn't effect on SR however. The water quality such as DO, temperature, salinity, and was TAN still in the optimum value.
EVALUASI KESESUAIAN PERAIRAN UNTUK BUDIDAYA IKAN BETUTU Oxyeleotris marmorata (BLEEKER, 1852) DI DESA RANTAU JAYA MAKMUR SUNGAI WAY PEGADUNGAN KECAMATAN PUTRA RUMBIA KABUPATEN LAMPUNG TENGAH
Authors: Diantari Rara , Damai Abdullah Aman , Pratiwi Leoni Dian
Published: December 2018

Way Pegadungan is a tributary of Way Seputih, has a length of 35.31 km and a river width of 50 to 70 meters. Way Pegadungan is very potential for aquaculture but has not been used optimally. This research was held in March - May 2018 using a descriptive quantitative method aimed at assessing the level of suitability of the waters by knowing the physical and chemical parameters for the cultivation of betutu fish. The data used primary data, namely the parameters of water suitability in the form of water quality values, while the secondary data is in the form of research location maps. Water suitability analysis was carried out using matching and scoring methods. The range of data obtained is depth: 6-7 m, brightness: 37,5-55 cm, temperature: 28-29ºC, pH: 7-8,21, dissolved oxygen: 4,02-6,73 mg / l, current : 0,14-0,16 m / s, nitrate: 0,16-0,21 mg / l, phosphate: 0,01-0,025 mg / l, ammonia: 0,01-0,065 mg / l, organic matter: 6,7-10,76 mg / l. Sampling stations were 4 stations determined by the global positioning system (GPS). At the first and fourth points get moderately sutable  (S2) and at the second and third points get marginal sutable (S3).
Pengaruh Cara Belajar Terhadap Hasil Belajar Siswa Pada Mata Pelajaran Ekonomi Kelas IPS SMAN 1 Pendalian IV Koto
Authors: Andria Vivi , Murdy Khairi , Suparmi Suparmi
Published: December 2018

This study aims to reveal the effect of learning methods on student learning outcomes in subjects in the Social Sciences class of SMA N 1 Pendalian IV Koto. This type of research is descriptive quantitative. The population is 197 people with a sample of 66 people using the Proportional random sampling technique. This research is quantitative research. The research instrument used was a questionnaire. Data analysis techniques using simple linear regression analysis. The results of the study showed that there were influences on how to learn about the results of learning economics. The magnitude of the contribution of learning methods to learning outcomes is equal to R2 0.501. This indicates that the way of learning contributes to student learning outcomes by 50.1%, while the rest is contributed by other factors that are not variables in this study.