bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on Recommendation Algorithm of Joint Light Graph Convolution Network and DropEdge
Authors: Qu Haicheng , Guo Jiangtao , Jiang Yanji
Published: January 2022

Overfitting in a deep neural network leads to low recommendation precision and high loss. To mitigate these issues in a deep neural network-based recommendation algorithm, we propose a recommendation algorithm, LG-DropEdge, joint light graph convolutional network, and the DropEdge. First, to reduce the cost of data storage and calculation, we initialize user and item embedding in the embedding layer of the algorithm. Then, to obtain high-order interaction relationships to optimize the embedding representation, we enrich the embedding by injecting high-order connectivity relationships in the convolutional layer. In the training phase, DropEdge is used to randomly discard connected relationships (interaction edges) to prevent overfitting. Finally, to reasonably aggregate the embedding results learned on all layers, the weighted average is expressed as the final embedding, so that users can make preferences in the item. We conduct experiments on three public datasets, using two performance indicators; namely, recall and NDCG, are used for evaluation. For the Gowalla dataset, compared with the optimal baseline method, recall@20 and ndcg@20 increased by 2.53% and 2.39%, respectively. For the Yelp2018 dataset, recall@20 and ndcg@20 increased by 6.17% and 5.58%, respectively. For the Amazon-book dataset, recall@20 and ndcg@20 increased by 4.82% and 4.67%, respectively. The results show that LG-DropEdge can not only reduce the degree of neural network overfitting but also improve the recommended results’ precision.
Novel Investigation of Fractional-Order Cauchy-Reaction Diffusion Equation Involving Caputo-Fabrizio Operator
Authors: Alesemi Meshari , Iqbal Naveed , Abdo Mohammed S.
Published: January 2022

In this article, the new iterative transform technique and homotopy perturbation transform method are applied to calculate the fractional-order Cauchy-reaction diffusion equation solution. Yang transformation is mixed with the new iteration method and homotopy perturbation method in these methods. The fractional derivative is considered in the sense of Caputo-Fabrizio operator. The convection-diffusion models arise in physical phenomena in which energy, particles, or other physical properties are transferred within a physical process via two processes: diffusion and convection. Four problems are evaluated to demonstrate, show, and verify the present methods’ efficiency. The analytically obtained results by the present method suggest that the method is accurate and simple to implement.
Construction of an Intelligent Evaluation Model of Mental Health Based on Big Data
Authors: Wei Zhang , Yan Liang
Published: January 2022

In this paper, mental health data were used to evaluate the educational effects, in which the high and low scorers of three emotions, autism, positivity, and anxiety, are compared separately to explore the subtle differences in the long-term trends of the sensing traits of people with opposite characteristics. Based on the fusion of multiple kinds of sensing traits, the differences in physical and mental health assessment of positive and negative emotions by different fusion trait approaches are explored, and speech and behavioural traits are fused to build a physical and mental health assessment system for positive and negative emotions. Energy gravity uses physical distance to estimate the residual energy of nodes and considers the energy distribution of downstream nodes. The main work is to combine the data of mental health of higher education students using data mining techniques, to analyze the feasibility study of mental health education of college students. Relevant definitions, classifications, tasks, processes, and application areas of data mining techniques are introduced, and the basic principles of data mining are analyzed in detail. Taking the mental health assessment data of new students as the research object, the decision tree algorithm is used to construct a decision tree model for students with depressive symptoms, and an association rule algorithm is used to data mine the relationship between factors of psychological dimensions. Finally, it can find out the hidden laws and knowledge behind the data information and analyze the relationship that exists between psychological problems and students.
MiR-483 Promotes Colorectal Cancer Cell Biological Progression by Directly Targeting NDRG2 through Regulation of the PI3K/AKT Signaling Pathway and Epithelial-to-Mesenchymal Transition
Authors: Sun Xifeng , Li Kun , Wang Huiling , Xia Yifang , Meng Ping , Leng Xiaogang
Published: January 2022

Background. Colorectal cancer is the third frequent tumor in the whole world. MiR-483, located at the 11p15.5 locus, acts as an oncogene in multiple tumors. The purpose of this study is to explore the important roles of miR-483 in colorectal cancer. Materials and Methods. RT-qPCR and western blot were applied to calculate the mRNA levels of miR-483 and genes. The Kaplan–Meier method was conducted to calculate the survival of patients with colorectal cancer. The proliferation and invasive abilities were measured by Methyl Thiazolyl Tetrazolium (MTT) and transwell assays. Results. MiR-483 was upregulated in colorectal cancer tissues, and the upregulation of miR-483 predicted poor prognosis of colorectal cancer patients. NDRG2 was a target gene of miR-483 in colorectal cancer. Furthermore, miR-483 has been reported to promote colorectal cancer cell proliferation and invasion through targeting NDRG2 by the PI3K/AKT pathway and epithelial-to-mesenchymal transition (EMT). In addition, the overexpression of miR-483 promoted xenograft growth of LOVO cells. Conclusion. MiR-483 promoted cell proliferation through the NDRG2/PI3K/AKT pathway and invasion-mediated EMT in colorectal cancer. In view of the multiple mechanisms of molecular immunotherapy, it is necessary to further study the relationship between miR-483 and colorectal cancer, so as to find a more direct and effective treatment method to prevent colorectal cancer.
Postoperative Curative Effect of Cardiac Surgery Diagnosed by Compressed Sensing Algorithm-Based E-Health CT Image Information and Effect of Baduanjin Exercise on Cardiac Autonomic Nerve Function of Patients
Authors: Zeng Fei , Luo Jing , Ye Jin , Huang Hao , Xi Wei
Published: January 2022

This research was aimed at exploring the effect of CT images reconstructed by optimized compressed sensing algorithm on postoperative diagnosis of patients with hypertensive heart disease and the influence of Baduanjin on cardiac autonomic nerve function. Based on the compressed sensing algorithm, the maximum likelihood expectation maximization algorithm was introduced to optimize it, and the optimization algorithm was established. The optimized algorithm and filtered back projection algorithm (FBP) were compared regarding the root mean squared error (RMSE), peak signal-to-noise ratio (PSNR), and structural similar image metric (SSIM). A total of 126 patients with hypertensive heart disease who underwent CT examination in the hospital were selected as study subjects. According to whether Baduanjin intervention was adopted, patients were divided into observation group (conventional treatment +Baduanjin) and control group (conventional treatment), with 63 patients in each group. The effect of CT examination on postoperative diagnosis was analyzed. Systolic blood pressure (SBP), diastolic blood pressure (DBP), differential pressure (DP), respiratory rate and heart rate (HR), very low-frequency (VLF) power, low-frequency (LF) power, high-frequency (HF) power, total power (TP) of HR variability, and changes in LF/HF of patients before and after treatment were compared. The RMSE of the compressed sensing optimization algorithm (

3.28
±
0.36

) was significantly lower than that of the FBP algorithm (

9.25
±
1.03

) (

P
<
0.05

). The SSIM and PNSR of the compressed sensing optimization algorithm were (

0.87
±
0.10

) and (

21.22
±
1.60

) dB, respectively. The SSIM was significantly higher than the FBP algorithm (

P
<
0.01

), and the PNSR was also higher than the FBP algorithm (

P
<
0.05

). The detection rate of CT for pleural effusion was 16 cases (25.40%) higher than 5 cases (7.94%) with TTE (

P
<
0.01

). After treatment, SBP, DBP, HR, LF, VLF, LF/HF, and DP values in the observation group were lower than those in the control group (

P
<
0.05

), and TP and HF were higher than those in the control group (

P
<
0.05

). It suggested that a novel algorithm was established based on compressed sensing algorithm to improve image quality. CT image had important guiding significance for postoperative diagnosis of heart. Baduanjin intervention could improve the integrated function of patient’s autonomic nervous system and the regulation ability of the vagus nerve.
Multicriteria Decision-Making Methods Using Bipolar Neutrosophic Hamacher Geometric Aggregation Operators
Authors: Jamil Muhammad , Afzal Farkhanda , Afzal Deeba , Thapa Dhana Kumari , Maqbool Ayesha
Published: January 2022

The study presents a novel conception of aggregation operators (AOs) based on bipolar neutrosophic sets by using Hamacher operations and their application in modeling real-life multicriteria decision-making problems. The neutrosophic set represents incomplete, inconsistent, and indeterminate information effectively. For better understanding in this paper, we have explained all essential definitions and their respective derived neutrosophic sets (NSs) and generalization bipolar neutrosophic sets (BNSs). The primary focus of our work is Hamacher aggregation operators like BN Hamacher weighted geometric (BNHWG), BN Hamacher ordered weighted geometric (BNHOWG), and BN Hamacher hybrid geometric (BNHHG) and their required properties. The proposed scheme provides decision-makers with a comprehensive view of the complexities and vagueness in multicriteria decision-making. As compared to existing methods, these techniques provide comprehensive, increasingly exact, and precise results. Finally, we applied different types of newly introduced AOs and numerical representation on a practical example to demonstrate the effectiveness of the proposed method. Our proposed model and its application have shown improved utility and applicability in the complex decision-making process.
Application Value of the Workshop Practice Teaching Method Based on Target-Oriented Study Modules on the Internet in Orthopedic Rehabilitation
Authors: He Qian , Ge Guanqun , Wu Qiong , Cui Yanchao
Published: January 2022

Objective. To explore the application value of the workshop practice teaching method based on target-oriented study modules on the internet in orthopedic rehabilitation. Methods. Thirty interns (2019-2020) in the rehabilitation department of our hospital were selected as the control group, another thirty interns (2021) in the rehabilitation department of our hospital were selected as the experimental group, and their materials were retrospectively reviewed. Both groups were given the three-month practice teaching. Besides, the conventional practice teaching method was applied to the control group, and the workshop practice teaching method based on target-oriented study modules on the internet was applied to the experimental group. After the practice teaching, the united examination paper and assessment table of the rehabilitation operation process were used to evaluate the interns’ scores of theoretical knowledge about orthopedic rehabilitation, scores of practical skills, and comprehensive scores of clinical practice in the two groups. The evaluation team consisting of 5 guiding experts in the scientific research office assessed the teaching quality of the two methods. Results. Compared with the control group, the experimental group had a notably higher score of theoretical knowledge about orthopedic rehabilitation, higher score of practical skills, and higher comprehensive score of clinical practice (92.47 ± 4.81 vs. 86.43 ± 5.12, 91.30 ± 5.68 vs. 81.53 ± 7.21, and 91.88 ± 2.45 vs. 83.98 ± 4.42,

P
<
0.001

). According to the evaluation team, the teaching quality of the experimental group was observably higher than that in the control group

P
<
0.05

, and there was no remarkable difference in the scores of teachers’ performance between the two groups

P
>
0.05

. Conclusion. The workshop practice teaching method based on target-oriented study modules on the internet, as a high-quality “Internet+” practice teaching mode, can improve the orthopedic interns’ scores of theoretical knowledge and practical operation ability and enhance their comprehensive qualities of orthopedic rehabilitation in all respects.
Efficiency and Reliability Analysis of Self-Adaptive Two-Stage Fuzzy Control System in Complex Traffic Environment
Authors: Wang Mingzhi , Wu Xianyu , Tian He , Lin Jie , He Meimei , Ding Liuqing
Published: January 2022

In this paper, a self-adaptive, two-stage fuzzy controller is established to realize the real-time online optimization of traffic signal timing plan, which takes multimodels of transportation as the research object to analyze the reliability of the control system at the isolated urban intersection. In this system, the first stage calculates traffic urgency degree for all red phases and selects the red phase with maximum traffic urgency degree as the next green phase. The second stage determines whether to extend or terminate the current signal phase. Aiming at the problems of the parameters of membership functions empirical settings and insufficient response to the real-time fluctuation in traffic flow, the controller introduces an improved hybrid genetic algorithm to solve it and enable the controller to self-learn. Finally, a microsimulation platform is constructed based on the VISSIM and Python language to evaluate the efficiency and reliability of the controller under complex actual traffic conditions. Results showed that the average delay time per vehicle is reduced by 14.59%, while the average number of stops per vehicle is reduced by 0.71% compared with the traditional control method. Results indicate that the traffic signal timing plan generated by the controller can efficiently improve the intersection traffic capacity and has good efficiency and reliability under the condition of medium saturation and unsteady flow.
Design a Services Architecture for Mobile-Based Agro-Goods Transport and Commerce System
Authors: Nchimbi Stivin Aloyce , Kisangiri Michael , Dida Mussa Ally , Barakabitze Alcardo Alex
Published: January 2022

Despite massive mobile phones adoption globally, Agriculture Supply Chain (ASC) in Tanzania is challenged by the low adoption of m-commerce integrated to m-payment and m-transport services as key information enablers for efficiently linking farmers to buyers. With such an inefficient and ineffective information gap, middlemen have become information custodians by decreasing farmers’ bargaining power in the market. In addressing the challenge, this study uses stakeholders to validate core services needed and proposes service architecture for Agro-Goods Transport and Commerce (AgroTC) system using installable and build-in mobile phone applications (internet web, mobile apps, and USSD). The proposed method appreciates a user-centric approach for system development. A scenario of the potato supply chain in Tanzania was considered where 2309 respondents were interviewed from farmers, buyers, and transport service providers from a predetermined sample size (n = 384) having a 95% confidence level. Data were collected using mobile phones configured with Open Data Kit (ODK) technology and analyzed using the R Studio tool with Pandas libraries. The results indicated that buyers were not interested in disease and land management information. Collectively, farmers (74%) and buyers (60%) highly demand m-commerce services as a virtual platform for linking them. Only farmers showed concern about disease management information. Furthermore, 35% of the farmers and 57% of the buyers need m-transport, whereas 35% of the farmers and 69% of the buyers need m-payment service. It was revealed that the remaining percentages lack knowledge on mobile phone features to perform online businesses. All transport service providers pointed to the challenge of existing middlemen in reaching customers and required technological change in managing transport systems. The proposed mobile-based AgroTC architecture provides a foundation business approach in Tanzania and many developing countries. System developers and innovators can use the proposed architecture design to design prototypes using the preferred language to meet ASC stakeholders’ needs and expectations.
Optimization of a Wireless Sensor-Based Tennis Motion Pattern Recognition System
Authors: Ruan Haoxuan , Zhang Xinchen
Published: January 2022

With the rapid development of information technology in today’s era, the application of the Internet, big data, and smart bracelet information technology in the field of sports has enhanced the intelligence of sports and plays an important role in promoting sports performance. This paper focuses on the application of wireless sensors in the field of tennis, using research methods such as literature research, video analysis, comparative research, and mathematical statistics, to explore and analyze the application of wireless sensors in the field of tennis big data, tennis robotics, and the implementation of tennis teaching and training, to provide a theoretical basis for promoting the application of wireless sensors in the field of tennis and also for the broader application of wireless sensors in sports to provide a theoretical reference. For the problem of multiple scales of motion targets in action videos, two video action recognition methods based on high- and low-level feature fusion are proposed, which are the video action recognition methods based on top-down feature fusion and the video action recognition methods based on bottom-up feature fusion. The multipowered mobile anchor nodes are allowed to move along a prescribed route and broadcast multiple power signals, and then, the location of the unknown node is estimated using a four-ball intersection weight center-of-mass algorithm. Simulations show experimentally that the algorithm reduces the average localization error and requires fewer anchor nodes.
The Value of Pulmonary Bedside Ultrasound System in the Evaluation of Severity and Prognosis of Acute Lung Injury
Authors: Li Lei , Yao Yanfen , Liu Shanshan
Published: January 2022

Objective. To evaluate the value of pulmonary bedside ultrasound system in the assessment of severity and prognosis of acute lung injury (ALI). Method. Seventy-two ALI patients in the intensive care unit (ICU) of our hospital from April 2019 to April 2021 were selected as subjects. The changes of lung ultrasound score (LUS) and parameters at D1, D2, and D3 after admission were analyzed (LUS, oxygenation index (PaO2/FiO2), Acute Physiology and Chronic Health Evaluation II (APACHE-II), and Sequential Organ Failure Assessment (SOFA) score). Pearson correlation analysis was used to assess the relationship between LUS and PaO2/FiO2, APACHE-II score, and SOFA score at D1, D2, and D3. Logistic regression analysis was used for influencing factors for the prognosis of ALI patients. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of baseline LUS, PaO2/FiO2, APACHE-II score, and SOFA score for the prognosis of ALI patients. Result. LUSs at D1, D2 and D3 showed an increasing trend with the increase of disease severity (

P
<
0.05

). From D1 to D3, LUS, PaO2/FiO2, APACHE-II score, and SOFA score showed a downward trend (

P
<
0.05

). LUS was negatively correlated with PaO2/FiO2 at D1, D2, and D3 but positively correlated with APACHE-II score and SOFA score (

P
<
0.05

). Logistic regression analysis showed that after controlling for age, PaO2 and PaCO2, an increase in baseline LUS, APACHE-II score, SOFA score, and a decrease in PaO2/FiO2 were independent risk factors for death at 28 d in ALI patients (

P
<
0.05

). ROC curve showed that LUS, PaO2/FiO2, APACHE-II score, and SOFA score were combined to predict the prognosis of ALI patients with the highest AUC value of 0.920, corresponding sensitivity of 88.89%, and specificity of 95.56%. Conclusion. LUS can evaluate the change of pulmonary ventilation area in ALI patients, further evaluate the severity of the disease, and effectively predict the prognosis of patients.
Example Analysis of Digital Wireless Mapping Applied to Construction Engineering Measurement
Authors: Wang Pengfei , Wang Yanli , Wang Maohui
Published: January 2022

This paper provides an in-depth study and analysis of the measurement of construction projects using digital wireless mapping and illustrates it using examples. Static measurements determine the relative positions between ground points with high accuracy using a baseline vector network composed of simultaneous observations by multiple receivers, using the correlation of errors in space and time. Technology-based on this error correlation, then the distance observation error or coordinate observation error measured by the base station is sent to the mobile station through the data chain to correct the station star distance observation or coordinate value of the mobile station, improving the operational accuracy and efficiency of the mobile station. The measurement avoids the tedious measurement organization work and long-time data collection and postcomputation work of static measurement, and the coordinates of the mobile station can be obtained in real-time. To verify whether the accuracy of the 3D model built by the 3D reconstruction method integrating UAV and camera (air ground) images can meet the accuracy requirements for the installation deviation detection of the assembled building components, the 3D reconstruction of the physical objects was completed by this method. The accuracy of the 3D model built by this method was evaluated by comparing the measurement coordinates of 25 prearranged checkpoints in the 3D model with those of the total station. The test results show that the maximum point accuracy of the 3D model is 2.305 mm, and the average medium error is 2.147 mm, which can meet the accuracy requirements of the installation deviation detection of the assembled building components. The detection of installation deviation of wooden columns was completed by measuring the 3D model, and it was verified that the method is intuitive, fast, accurate, and batch completion of the deviation detection of axis position, elevation, small labour, batch detection of components, and contactless mapping compared with the traditional detection methods.
Application and Evaluation of a 64-Slice CT Three-Dimensional Fusion Technique in the Determination of the Effective Ablation Margin after Radiofrequency Ablation of Hepatocellular Carcinoma
Authors: Du Haihao , Tan Xiongmu , Cheng Liuhui , Zhang Baopeng , Wang Daoqing
Published: January 2022

Due to the low accuracy of traditional three-dimensional fusion technology in radiofrequency ablation of hepatocellular carcinoma, this paper studies the advantages of three-dimensional CT fusion technology over traditional two-dimensional imaging technology in preoperative visualization and radiofrequency ablation path selection of hepatocellular carcinoma. To study the prognostic differences of hepatocellular carcinoma patients with different ablation margins (AM) in the three groups, so as to explore the best AM value, so as to minimize the liver injury caused by radiofrequency ablation. The selected patients underwent CT plain scan and three-phase enhancement at 1, 3, 6, and 12 months after operation and were rechecked every 6 months. For recurrent patients, CT was rechecked every three months. The images were obtained by GE 64-slice spiral CT. The thickness of the reconstruction layer is 1 mm, and the interval is 1 mm. The reconstructed image is imported into 3D fusion software. The three-dimensional images of tumor focus, hepatic artery, portal vein, and hepatic vein were reconstructed by two experienced doctors by superimposing the saved tumor images, merging the vascular images into the display, and measuring the ablation boundary (AM value). The results showed that the recurrence rate in group A was higher than that in group B (

P
=
0.041

), and there was no significant difference between group B and group C (

P
=
1.000

). Compared with traditional two-dimensional imaging, three-dimensional CT fusion technology can display the anatomical structure and three-dimensional spatial relationship of tumors and blood vessels and select the best radiofrequency ablation path, so as to achieve accurate radiofrequency ablation.
miR-154-5p Affects the TGFβ1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1
Authors: Bian Che , Luan Zhilin , Zhang Haibo , Zhang Ruijing , Gao Jing , Wang Yuxia , Li Jia , Ren Huiwen
Published: January 2022

Aim. The study is aimed at verifying miR-154-5p and Smurf1 combination in glomerular mesangial cells regulating TGFβ1/Smad3 pathway-related protein ubiquitination in the model of diabetic rats renal tissues, primary mesangial cells, and cell lines. Methods. The diabetic SD rat model and high-glucose-cultured primary mesangial cells and cell lines were established. miR-154-5p mimic and inhibitor, Smurf1 siRNA, and TGF β 1/Smad3 inhibitor (SB431542) were pretreated to make the TGFβ1/Smad3 pathway and ubiquitin changes. Fluorescence in situ hybridization was used for the miR-154-5p renal localization; molecular biological detection was adopted for cell proliferation, renal function, urine protein, and pathway proteins. After bioinformatics predicted binding sites, luciferase and Co-IP were used to detect miRNA and protein binding. Results. miR-154-5p was significantly increased and mainly concentrated in the glomerular of renal cortex in well-established diabetic rat renal tissues. Rno-miR-154-5p combined Rno-Smurf1 3

′

UTR, while Smurf1 combined Smad3 directly. Meanwhile, miR-154-5p regulates TGFβ1/Smad3-mediated cell proliferation via Smurf1 ubiquitination. Conclusion. miR-154-5p regulates the TGFβ1/Smads pathway through Smurf1 ubiquitination and promotes the fibrosis process of diabetic kidney disease.
Endometrial Regenerative Cell-Derived Conditioned Medium Alleviates Experimental Colitis
Authors: Sun Chenglu , Hao Jingpeng , Qin Hong , Zhu Yanglin , Li Xiang , Zhang Baoren , Qin Yafei , Li Guangming , Wang Hongda , Wang Hao
Published: January 2022

Background. Traditional interventions can play a certain role in attenuating ulcerative colitis (UC), known as one type of inflammatory bowel diseases, but sometimes are not effective. Endometrial regenerative cells (ERCs) have been shown to exert immunosuppressive effects in different models of inflammation, and stem cell-derived conditioned media (CM) have advantages over cell therapy in terms of easy access and direct action. However, whether ERC-CM could alleviate colitis remains unclear and will be explored in this study. Methods. Menstrual blood was collected from healthy female volunteers to obtain ERCs and ERC-CM. Acute colitis was induced by 3% dextran sodium sulfate (DSS), and ERC-CM was injected on days 4, 6, and 8, respectively, after induction. The disease activity index was calculated through the record of weight change, bleeding, and fecal viscosity during the treatment process. Histological features, macrophage and CD4+ T cell in the spleen and colon, and cytokine profiles in the sera and colon were measured. In addition, an in vitro lymphocyte proliferation assay was measured by using a CCK-8 kit in this study. Results. ERC-CM treatment significantly improved the symptoms and histological changes in colitis mice. ERC-CM increased the percentage of Tregs in the spleen and colon but decreased the percentages of M1 macrophages and Th1 and Th17 cells in the spleen and decreased the population of Th17 cells in the colon. In addition, ERC-CM treatment decreased the local expression of TNF-α, IL-6, and iNOS in the colon. Furthermore, ERC-CM increased the levels of anti-inflammatory cytokines IL-10 and IL-27 but decreased proinflammatory cytokines IL-6 and IL-17 in the sera. In addition, ERC-CM significantly inhibited ConA-induced mouse lymphocyte proliferation in vitro. Conclusion. The results suggest that ERC-CM can exert similar therapeutic effects as ERCs and could be explored for future application of cell-free therapy in the treatment of colitis.
Coherence Resonance Behavior of FitzHugh‐Nagumo Neurons Induced by Electromagnetic Field Driven by Phase Noise
Authors: Wu Kaijun , Zheng Huan , Li Tao
Published: January 2022

Noise exists widely in the nervous system, and plays a crucial role in the nervous system information processing. Noise can not only enhance but also weaken the ability of the nervous system to process information. Neurons are in a complex and variable electromagnetic field. Electromagnetic induction plays an important role in regulating the changes of neuronal membrane potential. Therefore, this paper simulates the electromagnetic field environment of the nervous system with a memristor and analyses the rich coherence resonance behavior of FitzHugh‐Nagumo (FHN) neuron system under the drive of phase noise. By taking the amplitude, period and noise intensity of phase noise as the main parameters and the parameters of memristor as auxiliary parameters, the two‐parameter changes are made from the angle of the amplitude and period of phase noise, the amplitude and intensity of phase noise, and the noise intensity and period of phase noise, respectively. The dynamic behaviors of coherent resonance of FHN neuron system are analyzed from the amplitude and period, amplitude and intensity as well as intensity and period of phase noise, respectively. When the amplitude and period of the phase noise and the intensity and period of the phase noise are used as independent variables for the two‐parameter analysis, the FHN neuron system shows rich dynamic behaviors such as coherence mono‐resonance, coherence bi‐resonance and coherence multi‐resonance. Especially when the amplitude and period of phase noise change as two‐parameter, the system presents a coherence resonance of discharge pattern with period‐adding cluster discharge at the valley. When the amplitude and intensity of phase noise are taken as independent variables for two‐parameter analysis, FHN neuronal system presents single or dual coherence resonance at any value of noise intensity with the change of phase noise amplitude. The simulated results show that the FHN neuron system demonstrates rich coherence resonance behaviors under the drive of phase noise when the effect of electromagnetic induction in the nervous system is simulated by memristor.
A Sight of the Diagnostic Value of Aberrant Cell-Free DNA Methylation in Lung Cancer
Authors: Zhao Hui , Zhang Hui , Xu Wei , Wen Baiqing , Kang Yani
Published: January 2022

Background. Lung cancer is one of the most commonly diagnosed cancer worldwide. As one of the liquid biopsy analytes, alternations in cell-free DNA (cfDNA) methylation could function as promising biomarkers for lung cancer detection. Methods. In this study, differential methylation analysis was performed to identify candidate markers, and lasso regression with 10-fold cross-validation (CV) was used to establish the diagnostic marker panel. The performance of the binary classifier was evaluated using the receiver operating characteristic (ROC) curve and the precision-recall (PR) curve. Results. We identified 4072 differentially methylated regions (DMRs) based on cfDNA methylation data, and then a 10-DMR marker panel was established. The panel achieved an area under the ROC curve (AUROC) of 0.922 and an area under the PR curve (AUPR) of 0.899 in a cfDNA cohort containing 29 lung cancer and 74 normal samples, showing outstanding performance. Besides, the cfDNA-derived markers also performed well in primary tissue datasets, which were more robust than the tissue-derived markers. Conclusion. Our study suggested that the 10-DMR marker panel attained high accuracy and robustness and may function as a novel and promising target for lung cancer detection.
Influence of Testosterone Depletion on Neurotrophin-4 in Hippocampal Synaptic Plasticity and Its Effects on Learning and Memory
Authors: Muthu Sakthi Jothi , Lakshmanan Ganesh , Seppan Prakash
Published: January 2022

Sex steroids are neuromodulators that play a crucial role in learning, memory, and synaptic plasticity, providing circuit flexibility and dynamic functional connectivity in mammals. Previous studies indicate that testosterone is crucial for neuronal functions and required further investigation on various frontiers. However, it is surprising to note that studies on testosterone-induced neurotrophin-4 (NT-4) expression and its influence on synaptic plasticity and learning and memory moderation are scanty. The present study is focused on analysing the localized influence of NT-4 on hippocampal synaptic plasticity and associated moderation in learning and memory under testosterone deprivation. Adult Wistar albino rats were randomly divided into various groups, control (Cont), orchidectomy (ORX), ORX + testosterone supplementation (ORX + T), and Cont + testosterone (Cont + T). After 2 weeks, the serum testosterone level was undetectable in ORX rats. The behavioural assessment showed a decline in the learning ability of ORX rats with increased working and reference memory errors in the behavioural assessment in the 8-arm radial maze. The mRNA and protein expressions of NT-4 and androgen receptors (ARs) were significantly reduced in the ORX group. In addition, there was a decrease in the number of neuronal dendrites in Golgi-Cox staining. These changes were not seen in ORX + T rats with improved learning behaviour indicating that testosterone exerts its protective effect on hippocampal synaptic plasticity through AR-dependent NT-4 regulation in learning and memory upgrade.
Polymorphism in Thymidylate Synthase Gene Predicts Survival and Toxicity in North Indian Lung Cancer Patients Undergoing Platinum-Based Doublet Chemotherapy
Authors: Sharma Parul , Singh Navneet , Sharma Siddharth
Published: January 2022

Abstract
Background: With an estimated 1.8 million deaths, lung cancer is one of the widely reported malignancies, with substantial morbidity and mortality rates. Thymidylate synthase (TS) is an important drug target for platinum-based doublet chemotherapy as it is the only de novo source of thymidylate production in the cell. TS polymorphisms in the 5'UTR of Thymidylate synthase enhancer region (TSER) 2R/3R and 3'- UTR 1494del6 are investigated in this study.
Methods: A total of 700 lung cancer patients with platinum-based doublet chemotherapy were recruited in this study. TSER (2R/3R) and TS 1494del6 polymorphisms in North Indian lung cancer patients were examined, and statistical analysis was performed.
Results: According to our findings, patients with the wild genotype (2R/2R) for the TSER polymorphism had a longer median survival time as compared to patients harboring the mutant type genotype (3R/3R) [MST=9.77 vs. 7.57 months; p=0.04]. On the contrary, patients with the mutant 14946del6 polymorphism (-6/-6) had a longer survival time than patients with the wild-type genotype (+6/+6) [MST=7.23 vs. 9 months]. Further, our findings elucidated that the patients with heterozygous genotype (2R3R) for TSER polymorphism had a 2.30-fold increased risk of developing leukopenia (AOR=2.30, 95% CI=0.96-5.52; p=0.05). A substantial risk of 5.14-fold constipation was found in heterozygous genotype (2R3R) when intermediate grade 2 toxicity was compared with low toxicity (grade 1) (p=0.007).An increased risk of nausea/vomiting was observed in patients with mutant genotype (-6/-6bp) for 1494 ins/del6 polymorphism compared to patients with wild-type genotype (+6/+6bp) (AOR= 2.77; 95%CI=1.10-6.96, p=0.03).

Conclusion: According to our findings, TSER and the 1494del6 polymorphism may operate as a prognostic marker in lung cancer patients receiving platinum-based chemotherapy. Furthermore, TS polymorphisms may influence the onset of platinum-related toxicity, such as hematological and gastrointestinal toxicity. These findings might facilitate therapeutic decisions for individualized therapy in lung cancer patients.
Keywords: Lung cancer, Thymidylate synthase, survival, platinum-based chemotherapy, polymorphism, toxicity
Feasibility of [18F]FDG PET/MRI with Early-Delayed and Extended PET as One-Stop Imaging for Staging and Predicting Metastasis in Rectal Cancer
Authors: Seto Shun , Tsujikawa Tetsuya , Sawai Katsuji , Kurebayashi Hidetaka , Morikawa Mitsuhiro , Okazawa Hidehiko , Goi Takanori
Published: January 2022

Background: We aimed to evaluate the diagnostic accuracy of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/magnetic resonance imaging ([18F]FDG PET/MRI) for preoperative staging and usefulness of the detection of extramural vascular invasion (EMVI) for predicting metastasis in rectal cancer. Methods: Twenty-three patients underwent pretreatment [18F]FDG PET/MRI, including early-delayed and extended PET and dedicated pelvic MRI without using anticonvulsant or contrast agents. Seven patients received preoperative treatment and all subsequently underwent surgery. Clinical cancer stages were evaluated using postoperative histopathology as a reference. PET/MR-defined EMVI (pmrEMVI) and pathological (p) TN stages were correlated with disease progression for a maximum of 2 years. Results: Of 16 patients without preoperative treatment, 10 had pT3, 4 tumors, 7 had pN1–3 lymph nodes, and 5 had synchronous metastases (SM; liver, lung, inguinal node). The sensitivity, specificity, and accuracy of PET/MRI were 90%, 67%, and 81% for T staging (T1, 2 vs. T3, 4), and 89%, 100%, and 94% for N staging (N0 vs. N1–3), respectively. Patient-based accuracy for SM staging was 100% (4/4). Of 23 patients, 6 were positive for pmrEMVI and 4 had metachronous metastases or local recurrence (MM; pelvic node, brain, lung, skin) during the follow-up periods. Five of the 6 pmrEMVI-positive patients had SM and/or MM (odds ratio = 37.5). Among pT, pN, and pmrEMVI, pmrEMVI-positivity was the only significant predictor for poorer progression-free survival (p < 0.05). Conclusions: [18F]FDG PET/MRI according to our suggested protocol is a one-stop, non-contrast, and valid diagnostic method for rectal cancer staging, and pmr­EMVI can be used as an imaging biomarker for predicting metastases.
Risk Factors for Surgery in Pediatric Patients with Crohn’s Disease
Authors: Rumenova Shentova-Eneva Rayna , Kofinova Denitza , Hadzhiyski Petyo , Ivanova-Todorova Ekaterina , Yaneva Penka , Lazarova Elena , Baycheva Mila
Published: January 2022

Objective: Pediatric Crohn’s disease (CD) has a more aggressive phenotype and course than in adults. Many patients develop complications that require surgery. The aim of this study was to identify the factors associated with increased risk for surgical intervention in pediatric patients with CD. Subjects and Methods: This study is a retrospective review of medical records. We analyzed the following variables: sex, age at diagnosis, presenting symptoms, duration of symptoms before diagnosis, disease location and severity, the presence of extraintestinal manifestations, and the presence of anti-Saccharomyces cerevisiae antibodies. Univariate analysis using the Mann-Whitney test and Fisher’s exact test was performed to detect the factors associated with surgery. Potential risk factors with p < 0.05 were further analyzed using a multivariate binary logistic regression model. Results: Fifty-seven patients (27 girls and 30 boys) were included in the analysis. More than one-fourth of them (28.1%) required surgical management. Female sex (p = 0.043), disease behavior (p = 0.012), and the presence of perianal disease at diagnosis (p < 0.001) were the variables associated with surgical intervention. Stricturing disease (B2) (odds ratio [OR], 24.944; p = 0.016), stricturing and penetrating disease (B2B3) (OR, 28.276; p = 0.011), and the presence of perianal disease at diagnosis (OR, 95.802; p = 0.001) were independent risk factors for surgery. Female sex was associated with surgery without being an independent risk factor. Conclusion: Females with B2 or B2B3 or the presence of perianal disease at diagnosis are at a higher risk for surgery and should be considered for more aggressive medical treatments.
Modelagem da dispersão atmosférica de material particulado (MP10) e os impactos da utilização de veículos de carga movidos a GNL em São Paulo
Authors: Borges Raquel Rocha , Teixeira Ana Carolina Rodrigues , Mouette Dominique , Ribeiro Flávia Noronha Dutra
Published: January 2022

O sistema de transporte brasileiro baseia-se no modo rodoviário, sendo os caminhões o principal veículo utilizado no transporte de mercadorias, responsável por 70% das emissões de material particulado (MP) veiculares do Estado de São Paulo. Por isso, é cada vez maior a busca por tecnologias alternativas para reduzir as emissões do setor de transportes. Tendo em vista a necessidade de reduzir poluentes e melhorar a qualidade do ar em grandes centros urbanos, o objetivo dessa pesquisa é calcular e analisar as emissões de material particulado com diâmetro de até 10μm (MP10) provenientes de veículos de carga rodoviários na Avenida Marginal Tietê, na cidade de São Paulo. O presente trabalho faz uso do modelo de dispersão atmosférica AERMOD para calcular as concentrações médias desse poluente, decorrentes da emissão dos caminhões movidos a Diesel, e os impactos da substituição de 100% deste combustível pelo gás natural liquefeito (GNL). Os resultados mostram que a substituição tecnológica auxilia na redução de 99% das emissões de MP10 ao longo do trecho da Avenida analisado, mas são necessários outros estudos para avaliar a concentração total e outros possíveis impactos, como os efeitos na saúde da população decorrentes da exposição desse poluente nessa via.
Soluções baseadas na natureza: quadro da ocupação da cidade de São Paulo por células de biorretenção
Authors: Pereira Maria Cristina Santana , Gobatti Lucas , Soares Mariana Corrêa , Leite Brenda Chaves Coelho , Martins José Rodolfo Scarati
Published: January 2022

O planejamento da paisagem urbana para aplicação sistêmica de Soluções Baseadas na Natureza (SbN) difere do planejamento urbano convencional ao valorizar a conservação da biodiversidade existente, junto a gerir o crescimento das cidades e aumentar a provisão de Serviços Ecossistêmicos (SE). Neste contexto, tem-se observado na cidade de São Paulo, através do incentivo de poderes públicos locais, a implantação de células de biorretenção como jardins de chuva, canteiros pluviais e biovaletas, tipos de SbN, que promovem uma gama de SE e contribuem principalmente à melhoria da qualidade das águas do escoamento superficial urbanas. Estas pequenas intervenções que rompem concreto e criam espaços permeáveis no tecido urbano produzem benefícios notáveis, mas precisam de atenção técnica de forma a garantir seu bom desempenho a longo prazo. Para que uma rede de infraestrutura verde urbana voltada à gestão de águas pluviais seja efetiva, é necessário criar espaços interconectados, incorporar sistemas de abatimento da poluição difusa, além de adotar tecnologias que apoiem os sistemas de macrodrenagem. Este artigo traz o quadro atualizado da implantação de células de biorretenção na cidade de São Paulo, destacando seus benefícios e trazendo uma visão crítica de sua aplicação corrente. Discute-se seu projeto, como seus fatores estruturais e cálculos básicos para parâmetros geométricos, planejamento e considerações geográficas, monitoramento e manutenção, incluindo aspectos participativos de planejamento destas estruturas. Desta forma, o artigo mapeia o que tem sido feito e o que é necessário melhorar para possibilitar a aplicação efetiva de células de biorretenção, de forma a tornar estas SbN reconhecidamente parte do arcabouço de tecnologias correntes para drenagem pluvial urbana em São Paulo.
The ability of Meloidogyne javanica to suppress salicylic acid-induced plant defence responses
Authors: Sahebani Navazollah , Gholamrezaee Nahid
Published: January 2022

Suppression of the defence system of plants by some plant pathogens is an important mechanism of their parasitism, and plant-parasitic nematodes use several mechanisms to affect different parts of the plant defence system. This study was designed to investigate the ability of a root-knot nematode, Meloidogyne javanica, to reduce or suppress the plant (tomato) immune system, before or after activation by a strong inducer, salicylic acid (SA). The experimental treatments were tomato plants inoculated with nematodes alone, plants pre-treated with SA and then nematodes (‘SA then nematode’), plants treated with SA after nematode inoculation (‘nematode then SA’), plants treated with SA alone, and plants treated with sterile distilled water. The results showed that treatment of the plants with SA before or after nematode infection reduced nematode disease indices compared to the control (nematode alone). The number of eggs per individual egg mass, in ‘nematode then SA’ treatment was significantly greater than the control, which shows the effect of nematodes on reducing the plant defence mechanism in this treatment. Evaluation of the activity of some defence enzymes such as chitinase, protease, phenylalanine ammonia lyase, catalase and density of hydrogen peroxide also showed that M. javanica is able to suppress these compounds in the ‘SA then nematode’ treatment, and to a greater extent in the ‘nematode then SA’ treatment. Suppression of plant defence responses by phytonematodes is of great importance in their synergistic relationship with secondary pathogens and plants.
“Abendland”, “Latin Civilization” and “Civilization of Death”: Civilizationism and Right-Wing Notions of Doom in Poland, Germany and Austria
Authors: Stübner Jos
Published: January 2022

In recent years one could observe a trend towards “civilizationism” within the European far-right. Civilization seems to be a transnational umbrella concept covering different subjects, such as racist, anti-Muslim, anti-migration stances as well as the defense of a heteronormative-patriarchal moral and gender order. While German-speaking right-wing actors usually refer to the concept of “Abendland” (Occident), in Poland “Latin Civilization” and “Civilization of Death” are popular terms. The article explores the ideological roots, sources and semantics of far-right civilizational ideas in Poland, Germany, and Austria. On the basis of such an approach it is possible to show how the idea of civilizational decline functions as an element of a metapolitical far-right strategy within separate national discourses and how the concept is part of a transnational transfer of ideas. The paper will also discuss to what extent the concept of (Western) civilization can serve as a common rightwing paradigm across different countries. While attempts at concrete collaboration by right-wing actors from different countries and their joint political practices reach their limits rather quickly, the transnational and entangled aspect of civilizationism consists primarily in a transfer of ideas, a common horizon of perception, and a mutually complementary, affirming yet ambivalent, East-West imagination.