bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARING ARCH WIDTH, ALVEOLAR WIDTH ANDBUCCOLINGUAL INCLINATION OF POSTERIOR TEETH IN SUBJECTS WITH CLASS IANDCLASS II MALOCCLUSION
Authors:   PG Student, Government Dental College and Hospital, Ahmedabad., V. Monisha , Mehta Falguni ,   Hod And Professor, Government Dental College and Hospital, Ahmedabad., Patel Renuka ,   Professor, Government Dental College and Hospital, Ahmedabad., Kumar Parekh Harshik ,   Assistant Professor, Government Dental College and Hospital, Ahmedabad., Goswami Megha ,   Assistant Professor, Government Dental College and Hospital, Ahmedabad., Barman Progynanika ,   PG Student, Government Dental College and Hospital, Ahmedabad.
Published: September 2023

Aim: The aim of this study was to compare the arch width, alveolar width and buccolingual inclination of posterior teeth between Class I and Class II Div 1 malocclusion subjects. Materials and method: A sample of120 subjects (60 males and 60 females) in the age group of 16-19 years with Class I and Class II Div 1 malocclusion were chosen and arch width, alveolar width and buccolingual inclination of posterior teeth were measured and compared between the groups. Result: The maxillary posterior teeth showed more palatal inclination in Class II Div 1 malocclusion when compared with Class I group. Conclusion:Transverse discrepancy in Class II Div 1 might be due to more palatal inclination of maxillary posterior teeth rather than arch width and alveolar width. Hence slow maxillary expansion should be preferred for correcting the palatal inclination rather than rapid palatal expansion.
A COMPARATIVE ANALYSIS OF PRIMARY & SECONDARY SCHOOL TEACHERS IN REFERENCE TO THEIR SELF CONFIDENCE
Authors:   Department of Teacher Education Bareilly College, Bareilly-243001 Uttar Pradesh, India., Singh Anita , Tomar Sweta ,   Research Scholar Department of Teacher Education Bareilly College, Bareilly-243001 Uttar Pradesh, India.
Published: September 2023

In the present study, an attempt has been made to compare the self confidence of primary and secondary school teachers of Bareilly District on the basis of 10 areas :-I- Physical Confidence, II - Technological Confidence, III - Social Confidence, IV - Psychological Confidence, V - Judgment Confidence, VI - Readiness Confidence, VII - Environment Confidence, VIII - Stage confidence, IX - Status confidence, X - Peer Independence Confidence. This study has been conducted on a sample of 114 primary and secondary school teachers selected randomly from schools affiliated to C.B.S.E. & U.P. Board. The main finding of the study exhibited significant difference between male and female, primary and secondary school teachers of C.B.S.E & U.P. Board. Male teachers were found to posses more physical confident as compared to that of female teachers. Further, significant difference in physical confidence was also found between male and female teachers of primary and secondary schools. No significant difference was found in other dimensions such as:-Technological Confidence, Social Confidence, Psychological Confidence, Judgment Confidence, Readiness Confidence, Environment Confidence, Stage Confidence, Status Confidence and Peer Independence Confidence.
Reactivity Studies and Synthetic Strategies Towards the Preparation of New Hydrophilic Indirubin-Triazole-Based Compounds
Authors: Fuzaro Ana Flávia , Ferreira Frederico Henrique , Suhett Gabriela , Costa Luiz Antônio , Grazul Richard , de Almeida Mauro , Ávila Eloah
Published: September 2023

Indirubin is an isomer of the blue dye indigo. It is widely used in Chinese medicine as part of therapy against many diseases and, thus, its skeleton becomes a promising candidate for new drug prototypes. Since it has low solubility, its properties could be improved through the insertion of hydrophilic and pharmacophoric groups, such as sugars bridged to 1,2,3-triazoles. Here, we report the synthesis of indirubin-based compounds evaluating two different routes: via the aldol condensation reaction of triazole-isatin derivatives with 3-acetoxyindole (pathway A) and reductive coupling of isatin, followed by N-propargylation of indirubin. We also performed reactivity studies guided by density functional theory (DFT) calculations (pathway B). As a demonstration, we simulate interactions with the glycogen synthase kinase 3β enzyme, which is associated with neurodegenerative diseases, through both molecular docking and molecular dynamics simulations.
Water quality monitoring in southern Brazil and the assessment of risk factors related to contamination by coliforms and Escherichia coli
Authors: Nascimento Santos Nathalia Geovana , Silva Luana Carvalho , Guidone Gustavo Henrique Migliorini , Montini Victor Hugo , Dias Oliva Bruno Henrique , Nascimento Arthur Bossi , de Sousa Diana Nara Ribeiro , Kuroda Emília Kiyomi , Rocha Sergio Paulo Dejato
Published: September 2023

The potability of water, including underground sources, is constantly affected by human activities. To assess water quality and water security in rural and urban areas of southern Brazil, a quantitative, retrospective analysis of water samples collected monthly by the Brazilian health authorities (19,687 samples from 2013 to 2021) was performed. In rural areas, 5,979 water samples (77.54%) were found to be contaminated by coliform bacteria and 3,431 (44.50%) by Escherichia coli. In addition, 1,616 (20.95%) of the contaminated samples were significantly correlated with rainfall amount. In urban areas, 1,268 (10.95%) of the samples contained coliform bacteria and 293 (2.53%) of these samples contained E. coli, with the factor of rainfall associated with 1,081 samples (9.33%) with bacterial contamination. In terms of physicochemical parameters, turbidity exceeded the national standard (5 uT) in 448 (2.32%) samples and fluoride fell below the required level (0.8 mg/L) in 106 samples (0.54%). The presence of free residual chlorine (0.2–2.0 mg/L) was verified in 846 samples (14.38%) in rural areas and in 10,825 samples (56.13%) in urban areas. These results suggest a strong association between rainfall factors and physicochemical alterations, as well as the risk of greater microbial contamination of water for human consumption.
Prática de oralidade em sala de aula
Authors: Rocha Damaris de Sales Costa Santos , Richartz Terezinha
Published: September 2023

Este artigo reflete, por meio de uma análise qualitativa, sobre o papel da escola atual que, inserida numa sociedade globalizada e de uso crescente das novas tecnologias, ainda não absorveu totalmente os benefícios dessa realidade, porém, paradoxalmente, deve propiciar o desenvolvimento e o preparo dos alunos para o trabalho e exercício da cidadania. Nos estudos da língua portuguesa, a demanda é favorecer uma participação mais efetiva e crítica nas práticas contemporâneas da linguagem, considerando os novos multiletramentos e práticas da cultura digital. A pesquisa se orienta para os desafios que correlacionam o currículo e a aprendizagem, envolvendo cultura, língua e identidade, como base importante para o estabelecimento da oralidade. Considera-se que os pontos destacados neste trabalho são fundamentais para a reflexão sobre uma educação mais coerente com a formação plena do educando.
Influence of COVID 19 on Nursing Students’ Career Identity: A Cross-sectional Study
Authors: Kim Na-geong , Park Hye-Ryeon
Published: September 2023

Background:

The Coronavirus disease 2019 has affected students’ education because they are more likely to be exposed to such infectious diseases during clinical practice in hospitals. This may result in inaccurate knowledge of coronavirus disease 2019 among nursing students and foster negative attitudes and fears about the virus, potentially resulting in negligent patient care.

Objective:

This study elucidates the relationship between nursing students’ knowledge, attitude, and fear of coronavirus disease 2019 and their career identity.

Methods:

We used structured self-reported questionnaires to assess knowledge, attitude, and fear about Coronavirus disease 2019 and career identity among 223 nursing students. We analyzed data using a t-test, Pearson’s correlation coefficient, and stepwise multiple regression.

Results:

Satisfaction with the actual clinical practice (β=0.35, p<0.001), knowledge of coronavirus disease 2019 (β=.25, p<.001), attitude toward coronavirus disease 2019 (β=.17, p=.002), and fear of coronavirus disease 2019 (β=.39, p<.001) influenced students nurses’ career identity.

Career guidance programs are needed to positively transform nursing students’ fear of Coronavirus disease 2019, to enhance their career identity. Educational content that can be used during clinical practice should be developed, to improve professional knowledge. Thus, the nursing students’ satisfaction with practice can be nurtured with a change of attitude toward infectious diseases. Besides active efforts and institutional arrangements at the national level, cooperation and feedback between schools and hospitals are important for nursing students to form a desirable career identity.

Conclusion:

Nursing students’ fear, knowledge, and attitude toward Coronavirus disease 2019 and satisfaction with the practice influence career identity. Moreover, it is necessary to develop educational content that can be used during clinical practice and improve professional knowledge. This will nurture the student nurses’ practice satisfaction and induce a change in attitude toward infectious diseases. Cooperation and feedback between schools and hospitals are of paramount importance for student nurses to form a desirable career identity, in addition to active efforts and institutional arrangements at the national level.
Evaluation of the operating conditions of the Stirling engine heat exchangers
Authors: Petrov A. I.
Published: September 2023

The development of modern energy is inextricably linked with the further improvement of heat engines, which are still the only primary sources of mechanical energy on an industrial scale. Given the existing environmental problems, Stirling engines can be a good alternative to internal combustion engines and turbines. Of the many problems of creating such a sufficiently powerful and economical engine, it is customary to consider three main ones: 1) efficient transfer of large heat fluxes in the heater, regenerator and refrigerator; 2) creation of reliable and durable seals to hold the working fluid in the cylinder; 3) ensuring minimal friction in bearings and seals. And yet, of the three listed problems, the first should be given more attention, first of all, due to the unique conditions associated with the continuously changing thermo and mechanical loads. The instability of the loads is further complicated by the sharply different heat transfer coefficient on the external and internal heat transfer surfaces. That is, there are factors that contradict the requirements for the size of the heat transfer surface, the friction resistance of the working medium and the dead volume of the engine as a whole. In this regard, it is of interest to search for possible ways to reduce the effect of negative factors of non-stationary heat transfer in the calculation of heat exchangers. The current lack of suitable theoretical methods of calculation forces the use of semi-empirical methods. The aim of the paper is to assess the significance of the unique, characteristic of Stirling engines, the negative phenomenon of the delay in the flow of the working fluid in heat exchangers. For this purpose, a real kinematic diagram of the movement of the engine pistons with a rhombic drive by R. Meyer, created using the design program, is used. The analogue is the 4–235 type real engine of the Philips Company. In the calculations, a step-by-step procedure for calculating the time-varying parameters of the working fluid is used. The need for such a solution is due to the fact that in the rhombic drive of R. Meyer, the pistons movement and the change in the displaced volumes complexly depend on the angle of rotation of the engine shaft. In addition, the exact value of the real change in volume is possible only when the terms of the analytic equation of volume change under consideration are decomposed into a Fourier series.
Experiencias vividas durante el cuidado de la salud de personas sin hogar
Authors: Rodríguez Flores Andrea
Published: September 2023

Introducción: Enfermería ha contribuido al cuidado de las personas más vulnerables, como aquellas que no tienen un hogar y experimentan un sentido de no pertenencia al carecer de protección tras sufrir el rechazo de los servicios básicos de apoyo y de asistencia específicos.Objetivo: Develar la experiencia vivida en torno a la salud durante el cuidado de personas sin hogar.Métodología: Cualitativo fenomenológico hermenéutico, según Heidegger. Se identificó a los participantes a través de muestreo por cadena de referencia. La información fue recolectada por medio de entrevistas fenomenológicas grabadas y transcritas con el método de Jefferson. El análisis de la información se realizó artesanalmente.Resultados: Los participantes incluidos fueron cinco hombres sin hogar de entre 19 a 50 años residentes en un albergue urbano. La experiencia de salud se vivió desde tres unidades ontológicas: El cuidado en la escasez de las personas sin hogar, Centros de in-rehabilitación, Sobrevivir a la falta de hogar; y dos unidades ónticas: Incertidumbre del mañana para las personas sin hogar, Esperanza final: fe y religión.Discusión: Las condiciones infrahumanas del vivir sin hogar deterioran la salud, lo que dificulta la salida de la calle; no obstante, un acercamiento a dicho fenómeno permite al profesional de enfermería fundamentar la base para crear e implementar alternativas que garanticen el cuidado y así evitar permanecer en la indigencia.Conclusiones: El cuidado de las personas sin hogar debe tener en cuenta su trayectoria de vida; los profesionales de salud son responsables de implementar acciones emancipadoras encaminadas a una atención individualizada e integral.
Experiencias cotidianas de mujeres diagnosticadas con hipertensión arterial sistémica residentes de la Ciudad de México
Authors: Fernández García María Victoria
Published: September 2023

Introducción: La elevada prevalencia de hipertensión arterial sistémica es un problema de salud pública a nivel mundial. Se requiere profundizar, desde una perspectiva crítica, acerca de los aspectos que subyacen a la falta de control y en la complejidad de los contextos de pobreza.Objetivo: Analizar desde una perspectiva crítica la configuración de la experiencia y el significado de padecer hipertensión, en tres casos de mujeres que habitan en un contexto multicultural, de pobreza y trabajo agrícola de Ciudad de México.Metodología: Estudio de corte etnográfico, con seguimiento de más de dos años a tres  mujeres en sus contextos. Se realizó observación participante, entrevistas en profundidad  e informales. El análisis de las entrevistas fue desde la fenomenología crítica. Resultados: Se identificaron las categorías: inicio y malestares; experiencia de la  enfermedad (vida cotidiana). Los resultados mostraron complejos entramados que  reflejan las tensiones y dinámicas derivadas de contextos de pobreza estructural y de  género. La enfermedad fue atendida en crisis como resultado de la cultura somática, configurada por las condiciones materiales de vida que definen la búsqueda de atención. Discusión y Conclusiones: La investigación muestra la sinergia de diferentes factores de  los contextos que derivan en la falta de atención y en una cultura somática en la que se  normalizan los malestares, la enfermedad, así como la desigualdad de género. La experiencia de la enfermedad fue modulada predominantemente por la situación económica y el género.
Determinantes de la transparencia fiscal en América Latina
Authors: Desfrancois Pierre
Published: September 2023

La transparencia fiscal ha sido consistentemente identificada como una característica clave de una política fiscal eficiente y un requisito previo para una buena gobernanza pública. Se examinan los determinantes de la transparencia fiscal en América Latina, a partir de un modelo de panel de efectos fijos, de una muestra de 13 países de América Latina que cubre el periodo 2006-2021. Los resultados arrojan que la calidad regulatoria es un determinante importante de la transparencia fiscal en la región, evidenciando la importancia de las instituciones en las políticas fiscales. Sin embargo, la abundancia de recursos naturales y la apertura comercial no tienen un impacto significativo en la transparencia fiscal, medida a través del índice de presupuesto abierto. Una buena calidad regulatoria implica que las leyes y reglamentos fiscales estén disponibles y sean accesibles al público de manera clara y comprensible. Al establecer reglas claras y efectivas, se reduce el margen para la discrecionalidad y la arbitrariedad en la aplicación de las normas fiscales. Los resultados contribuyen a reforzar los conocimientos sobre los determinantes y la importancia de la transparencia fiscal en los países de la región.
Trata con fines de explotación sexual en México: La mercantilización del cuerpo de las mujeres
Authors: Hernández-Gutiérrez Regina Isabel
Published: September 2023

La trata de personas es un fenómeno presente de forma global. En México, la que se lleva a cabo con fines de explotación sexual, cuenta con un mayor porcentaje de víctimas identificadas, quienes; además, son mujeres y niñas principalmente. Esto conlleva a colocar sobre la mesa de discusión que la identidad y corporeidad de las mujeres sigue atravesada por constructos sociales que devienen de un sistema y cultura patriarcal, que las hace objetos y deshumaniza para uso y placer de otros. Aunado a ello, se encuentra el sistema capitalista que ha encontrado en esta práctica una veta de ganancias para la acumulación al convertir a estas mujeres en mercancías. De esta manera, en la  trata con fines de explotación sexual, se concreta la relación existente entre capitalismo y patriarcado al ser el cuerpo de las mujeres ya no sólo objeto de placer, sino mercancía que puede ser vendida al mejor postor. Para el presente artículo, en cuanto a la metodología, se recurrió a la revisión bibliográfica de informes y diagnósticos sobre el tema, ya que es un estudio documental. Asimismo, el análisis de los más recientes informes publicados sobre el tema en México, permite hacer énfasis en la situación de las mujeres como víctimas de trata con fines de explotación sexual, dado que el informe global del 2020, señalaba una presencia mayor de este grupo en esta modalidad de trata. De esta manera, es posible sustentar que la explotación sexual se basa en el uso de los cuerpos femeninos y es una forma de violencia.
Tipificación del delito de trata de personas en Centroamérica, México y España
Authors: Mora-Barquero Alonso
Published: September 2023

Esta investigación presenta una propuesta innovadora al realizar un estudio de derecho comparado sobre el tipo penal de trata de personas incorporado en las legislaciones centroamericanas de habla hispana; además de México y España, como referentes hispanos en Norteamérica y Europa a la luz del Protocolo de Palermo. El principal objetivo es evidenciar las diferencias y similitudes con respecto a las legislaciones vigentes en Costa Rica, Panamá, Nicaragua, Honduras, El Salvador, Guatemala, México y España que pueden representar aciertos para la persecución y la sanción del delito de trata de personas. Conviene mencionar que el estudio se aborda desde un punto de vista jurídico descriptivo y de derecho comparado, con un enfoque de Derecho Internacional, sustentándose principalmente en el carácter jerárquico superior que ostentan los instrumentos internacionales, respecto a las obligaciones internacionales contraídas. De esta manera, se utiliza como base para el análisis el concepto de trata de personas que brinda el Protocolo de Palermo y se comparan los elementos que constituyen el delito de cada uno de los tipos penales de cada país incluidos en este estudio, identificando diferencias y similitudes. Como resultado principal, se encuentra que los países en estudio cumplen en su generalidad con las exigencias del Protocolo de Palermo; sin embargo, se podrían incluir varios elementos presentes en otras legislaciones para fortalecer el tipo penal que actualmente poseen, tanto en cuanto a las acciones o verbos rectores tipificados, así como en cuanto a la redacción de los medios comisivos y los fines incluidos.
Movilización digital, una oportunidad en la lucha contra la trata de personas: Aproximaciones teóricas y miradas a las redes de la Alianza Colombiana de Organizaciones de la Sociedad Civil en contra de la trata de personas
Authors: Sánchez-Tamayo Robinson
Published: September 2023

La literatura sobre movilización social viene prestando atención al creciente uso de redes sociales y la producción de contenidos digitales por parte de activistas en los que se promueven, explican o describen sus causas. Aunque esta literatura se ha enfocado principalmente en contextos angloparlantes, América Latina no es la excepción y muchas organizaciones sociales han encontrado en las redes sociales espacios de movilización. Desde esta perspectiva, este artículo expone las posibilidades del activismo digital a las organizaciones sociales para movilizar ideas sobre la lucha contra la trata de personas en el país. Con ello se espera aportar a los estudios sobre movilización social en contra de la trata de personas, particularmente sobre movilización digital en América Latina y en Colombia. Se realizó una revisión bibliográfica de la literatura gris y académica sobre la materia y el rastreo de contenidos en las principales redes digitales en la región, tales como Twitter, Instagram y Facebook de algunas organizaciones colombianas.
Avances jurídico-institucionales en materia de tráfico de migrantes en México
Authors: Guadarrama-Muñoz Alma Cossette , López-Pérez Lourdes
Published: September 2023

La migración como fenómeno social cobra importancia al estar presente en todos los Estados. México no es la excepción, al ser suelo de recepción, retorno, salida y tránsito de diversas corrientes, lo que ha generado la aparición y proliferación de traficantes, quienes a la luz de los vacíos legales y ante la ausencia de estrategias gubernamentales concretas aprovechan la situación para convertir a las personas migrantes en mercancías, cosificándolas ante la mirada indiferente de la autoridad y la invisibilidad de la sociedad. El objetivo de este trabajo es analizar la legislación mexicana en la materia y la política pública implementada por el actual gobierno, con el fin de identificar los progresos realizados y los retos que aún quedan pendientes. Se parte de la pregunta de investigación ¿Cuáles son los avances jurídico-institucionales en materia de tráfico de migrantes en México? La hipótesis que se sostiene es que los avances no han sido significativos, a pesar de que el gobierno actual tiene una orientación de izquierda y un discurso de protección de derechos. La principal conclusión a la que se arriba es que los avances en tráfico de migrantes son ínfimos, porque están alineados con los intereses geopolíticos de EE UU y no con los compromisos internacionales, lo que ha impedido hacer frente a los retos que representa este flagelo para la dignidad de las personas migrantes.
Process of grievance management in health care organization: An employee perspective
Authors: Gulzar Rafia , Rehman Shakeel , Radouch Taoufik
Published: September 2023

An investigation into the grievance management process of organizations is imperative with an increasing concern over healthy work cultures in organizations. Using a behavior-response model, a structured survey was administered to employees of a leading healthcare institute to explore their perspectives on the grievance management process. According to the findings of the study, there is a strong association between grievance management constructs and the grievance management process, and factors like acceptance of grievance by supervisors, supervisors’ attitudes toward grievant, and employee and supervisor trust play an important role in grievance resolution (Monish & Dhanabhakyam, 2022; Ochieng & Kamau, 2021; Elbaz et al., 2022; Casper, 2021; Kimotho & Ogol, 2021; Dichner, 2021; Aktar, 2021; Singh & Agarwal, 2022; Hammoud et al., 2022). Based on the findings, the study delivers implications for organizations to prevent chaos, stress, and conflict in the workplace through a better grievance management process.
Do the six types of Sri Lanka's Oryza comprise a domesticated-weed-wild complex?
Authors: Tennakoon Asanka , Sandamal Salinda , Ge Song , Melo Arthur , Zhao Yao , Marambe Buddhi , Ellstrand Norman , Song Beng-Kah , Ratnasekera Disna
Published: September 2023

Genetic studies of Domesticated-Weed-Wild Complexes (DWWC) have
typically focused on one-way introgression of crop alleles into wild or
weedy populations, with little consideration of the entire natural
ecosystem. In Sri Lanka, DWWC is diverse, comprising six evolutionarily
discrete groups in the genus Oryza. Using 33 neutral simple sequence
repeat (SSR) loci, we characterized six Oryza groups to understand the
genetic background and evolution of DWWC components. Our analysis found
that Oryza groups have large population sizes and high inter-group
long-term gene flows. Asymmetric gene flows were found between wild and
weedy rice groups, but the rare alleles shared among DWWC components
provide additional evidence for extensive and enduring exchange,
highlighting the dynamic nature of this complex genetic admixture among
different Oryza lineages. We found high genetic diversity at the
population and species levels due to mixed DWWC components over the
generations. Weedy rice types exhibit genetic incorporation through
admixture from both crop and wild species, highlighting the multi-way
genetic transfer in the evolution of weedy rice types. Our findings
support the idea that the DWWC is an integrated complex in the Sri
Lankan rice ecosystem and that its weedy rice has multiple origins,
including de-domestication via feralization of cultivated rice,
inter-varietal hybridization among distinct cultivated rice types,
adaptation, and invasion of rice cultivation areas by wild Oryza
species, and hybridization events between crop and wild rice
populations. Abandoned rice domesticates can also evolve into weedy
forms with less intimate human relationships and contaminate the rice
ecosystem.
Inductive Power Transfer System for CC/CV Charging Based on Secondary Variable Inductor
Authors: Zhao Qinglin , Liang Mingyao , Wang Tao , Gao Jinlong , Wang Deyu
Published: September 2023

In response to the demand for battery packages in electric vehicles
(EVs), a charging system with constant current (CC) and constant voltage
(CV) two-stage output characteristics should be designed and
implemented. This paper proposes an inductive power transfer (IPT)
system with a double-sided inductor-capacitor-capacitor (LCC)
compensation network connected with a series variable inductor (VI) on
the secondary side. An IPT prototype with a transfer distance of 150mm
and an output power of 3kW is built. In addition, within the set
misalignment range, A constant current output mode of 7.85A and a
constant voltage output mode of 400V can be achieved successively,
avoiding adding DC/DC converters. The experimental results show
that the energy transfer efficiency reaches 87.9% with the alignment of
the magnetic coupling mechanism.
Tau-Targeting Nanoparticles for Treatment of Alzheimer's Disease
Authors: Pawar Shreya , RAUF MOHDAHMAR , Iyer Arun , Abdelhady Hosam
Published: September 2023

Alzheimer’s Disease (AD) is a neurodegenerative disorder that causes
loss of neural connections in the cells, and brain tissue volume. The
disease first affects the hippocampus and entorhinal complex, which
produce memories, then the cerebral cortex, which controls language,
logic, and social conduct. Genetic mutations and environmental factors
may cause AD, but the exact reason is unknown. AD is diagnosed using CT
scans, MRIs, PET scans, and lumbar punctures to detect brain
abnormalities, aberrant protein deposits, and cerebrospinal fluid
biomarkers. Beta-amyloid plaques and neurofibrillary tau tangles impede
neuronal transmission and function in AD. AD also causes chronic
inflammation, blood-brain barrier impairment, brain atrophy, and
neuronal death. AD has no cure, and current medications mainly manage
symptoms and halt cognitive loss. Genetic, cellular, and molecular
pathways are being studied to develop targeted medicines to stop disease
progression. Extensive studies have shown that tau tangle accumulation
and pathogenic changes to tau protein mechanics are correlated with AD
pathogenesis. Thus, investigating the potential for therapies focused on
restoring normal tau pathways and preventing tau accumulation is
critical. Nanoparticulate drug delivery technologies may improve
investigational medicines and lead to AD therapy breakthroughs.
In vitro drug-drug interactions in rat liver between oxycodone and commonly co-consumed drugs
Authors: Gu Weilong , Tyndale Rachel
Published: September 2023

Background and Purpose: The co-use of opioids and other drugs is
prevalent, both in a clinical setting and during opioid misuse. We
investigated whether drug-drug interactions occur between oxycodone and
xylazine, diazepam, etizolam, and methamphetamine using rat liver
microsomes. Experimental Approach: Michaelis–Menten parameters (Km,
Vmax), and intrinsic clearance (CLint) of oxymorphone and noroxycodone
formation were determined. Inhibition Kis for xylazine, diazepam, and
etizolam were assessed. Inhibition of oxycodone and dextromethorphan
(probe substrate) metabolite formation by selective P450- and
test-inhibitors was investigated. Key Results: Km values of oxymorphone
(75 μM) and noroxycodone (74 μM) formation were similar. The Vmax of
noroxycodone formation (1235 pmol/min/mg) was higher than oxymorphone
(354 pmol/min/mg), leading to three times higher CLint of noroxycodone.
Xylazine and etizolam were competitive inhibitors of oxymorphone (Ki =
0.5 and 9.5 μM, respectively) and noroxycodone (Ki = 2.6 and 14.6 μM,
respectively) formation, while diazepam was a competitive inhibitor of
oxymorphone formation (Ki = 3.7 μM) and a mixed inhibitor of
noroxycodone formation (Ki = 8.3 μM). Xylazine, diazepam, and etizolam,
as well selective P450-inhibitors, were confirmed to inhibit both CYP2D-
and CYP3A-mediated pathways in rat liver microsomes. Methamphetamine was
a moderate inhibitor of oxymorphone formation, and weak inhibitor of
noroxycodone formation. Conclusion and Implications: Xylazine, diazepam,
and etizolam are potent inhibitors of the formation of both primary
oxycodone metabolites and leading to potential drug-drug interactions.
Further, xylazine, diazepam, and etizolam could inhibit both CYP2D- and
CYP3A-mediated pathways, leading to potentially altered drug metabolism
of other opioids and substrates.
Multi-integrated genomic data for Passiflora foetida provides insights into genome size evolution and floral development in Passiflora
Authors: Zou Yi , Wang Jie , Peng Dan , Zhang Xiaoni , Tembrock Luke , Yang Jinliang , Zhao Jianli , Liao Hong , Wu Zhiqiang
Published: September 2023

Passiflora is a plant genus known for its extremely distinctive
and colorful flowers and a wide range of genome sizes (over ten-fold
variation). However, the relationship between differences in genome size
and organization and the variations in flower size and morphology among
Passiflora species remains largely unexplored. Here, we assembled
a chromosome-scale genome of Passiflora foetida, which is a close
relative of the commercial passionfruit P. edulis. While the
genome of P. foetida contains a substantial proportion of
repetitive elements (66.7% of 424.16 Mb), it possesses significantly
fewer copies of long terminal repeat retrotransposons (LTR-RTs) compared
to P. edulis (83.94% of 1278.14 Mb; 87.29% of 1241.66 Mb). The
disparity in LTR-RTs is one of the main contributors to the differences
in genome sizes between these two species and possibly in floral traits.
Additionally, we observed variation in insertion times and copy numbers
of LTR-RTs across different TE lineages. Then, by integrating
transcriptomic data from 33 samples (eight floral organs and flower buds
at three developmental stages) with phylogenomic and metabolomic data,
we conducted an in-depth analysis of the expression, phylogeny, and copy
number of MIKC-type MADS-box genes and identified essential biosynthetic
genes responsible for flower color and scent. Our study provides new
insights on genome size variation and the evolution of flower
development in two important Passiflora species.
Hopf and zero-Hopf bifurcations for a class of cubic Kolmogorov systems in R3
Authors: Wang Qinlong , Lu Jingping , Wang Chunyong , Huang Wentao
Published: September 2023

In this paper, Hopf and zero-Hopf bifurcations are investigated for a
class of three-dimensional cubic Kolmogorov systems with one positive
equilibrium. Firstly, by computing the singular point quantities and
figuring out center conditions, we determined that the highest order of
the positive equilibrium is eight as a fine focus, which yields that
there exist at most seven small amplitude limit cycles restricted to one
center manifold and Hopf cyclicity 8 at the positive equilibrium.
Secondly, by using the normal form algorithm, we discuss the existence
of stable periodic solution via zero-Hopf bifurcation around the
positive equilibrium. At the same time, the relevance between zero-Hopf
bifurcation and Hopf bifurcation is analyzed via its special case, which
is rarely considered. Finally, some related illustrations are given by
means of numerical simulation.
A prosztatarák diagnosztikája – fúziós biopszia
Authors: Hüttl András
Published: September 2023

A cikk a multiparametrikus MR-vizsgálat és a fúziós biopszia szerepét ismerteti a prosztatarák diagnosztikája során. A szerző ismerteti a fúziós biopszia típusait: kognitív, direkt MR-ben végzett, szoftveralapú fúziós biopszia. Továbbá rámutat a fúziós biopszia előnyére a hagyományos biopsziával szemben. Fúziós biopszia segítségével hatékonyabban tudjuk felfedezni a klinikailag szignifikáns tumorokat, és kisebb eséllyel fedezünk fel olyan daganatokat, amelyek nem igényelnének további aktív kezelést.
A nem metasztatikus kasztrációrezisztens prosztatarák
Authors: Riesz Péter , Szűcs Miklós , Szalontai János , Horváth András
Published: September 2023

A prosztatarák a leggyakoribb urológiai rosszindulatú megbetegedés. A szerzők jelen tanulmányukban a nem metasztatikus kasztrációrezisztens prosztatarák definícióját, epidemiológiai adatait, diagnosztikáját és kezelési lehetőségeit tárgyalják. Az nmCRPC-s betegek egyharmadánál két éven belül metasztázis alakul ki. A betegeknek csak 2-8%-a tartozik ebbe a csoportba, de jelentőségét az adja, hogy a magas rizikójú betegek kezelésére az elmúlt években hatékony készítményeket fejlesztettek ki. 2018 óta három gyógyszerrel is sikerült a metasztázismentes időt, a tünetmentes időt és a teljes túlélés idejét is megnövelni. Ennélfogva az onkológusok és urológusok legfontosabb feladata, hogy a kezelésük alatt álló betegek között észleljék azokat a nem metasztatikus kasztrációrezisztens eseteket, akiknek magas a rizikójuk a csontáttét kialakulására, mert lehetőségük van a hosszabb tünetmentes és teljes túlélés biztosítására.
Impact of Diabetes Distress on Glycemic Control
Authors: W Abdelghaffar
Published: September 2023

Introduction: Diabetes related distress is a recent entity that was found to be associated with poor glycemic control but it was never assessed in Tunisia nor in african countries. This study aimed at exploring the relationship between diabetes related distress and glycemic control. Methods: Cross-sectional study assessing diabetes related distress (using Problem Areas in Diabetes Scale PAID-5) and treatment adherence (using Medication Adherence Questionnaire de Morisky-Green) and glycemic control using HbA1c in Tunisian patients with Type 2 diabetes. Results: There was a statistically significant association between high PAID-5 scores and poor glycemic control. A threshold of 8.5 on PAID-5 predicts poor glycemic control and complications. Conclusion: It is recommended to screen for diabetes related distress using PAID-5 in order to detect patients with high risk of poor glycemic control and complications.
Pemanfaatan Bonggol Jagung Sebagai Bahan Campuran Pembuatan Paving block Porous
Authors: Pratama Firmansyah Ully , Rahmawati Winda , Wisnu Febryan Kusuma , Suharyatun Siti
Published: September 2023

The development needs of the population that continues to increase cause a mismatch in land use. This can make it possible to reduce water catchment areas in any areas with dense building growth. The use of cement in both housing and road construction results in reduced water absorption areas because cement has properties that make it difficult to absorb water, so water will become stagnant. Therefore, a cement substitute is needed to cover the shortage of cement. The addition of corn cobs in the paving block mortar is expected to increase its water absorption without reducing the compressive strength of the paving blocks. This is done to reduce corn cob waste and save on staple food costs. as well as being used as a useful product innovation in reducing corn cob waste. After printing is complete, the porous paving blocks are dried in the sun and conditioned for approximately 21 days, then the porous paving blocks are ready to be tested. The experimental design consisted of 4 treatments, namely C1, C2, C3, and C4. For the density test, values were obtained with an average of 1.327 g/cm3 – 1.628 g/cm3. For the infiltration test, a value of 0.274 mm/s was obtained. Whereas the visible test is obtained with the appropriate form of paving texture obtained on factor C4 because the resulting texture is good and there are no gaps or defects when the paving has been printed. The highest value from the water absorption test occurred in the C4 treatment with a value of 23.91%. The effect of corncob waste on Porous Paving Blocks in this study is that the more corncob waste fiber is used, the more porous paving block cavities will be, and vice versa if using less corncob waste fiber, the pore cavities will be larger. produced on porous paving blocks will be less. Keywords: Corn Cogs,  Paving block Porous.
Yağış-Akış İlişkisinin GEP ve ANFIS İle Modellenmesi
Authors: YAMAN Yunus , ÖNEN Fevzi
Published: September 2023

Yağış-akış ilişkisinin doğru bir şekilde modellenmesi, su kaynaklarının yönetimi ve su taşkınlarının kontrolü gibi hidrolojik uygulamalar için hayati önem taşımaktadır. Ancak hidrolojik sistemlerin karmaşıklığı ve nonlineer özellikleri nedeniyle, yağış-akış ilişkisi gibi olayları tanımlamak için hala birçok model geliştirilmektedir. Özellikle son yıllarda küresel ısınma ve küresel iklim değişimi gibi etmenler, yağış-akış ilişkisini belirlemeyi daha da önemli hale getirmiştir. Bu nedenle, yapay zeka teknikleri gibi modern yaklaşımların kullanımı giderek artmaktadır.

Bu çalışmada, havza yağış-akış modellemesi için iki farklı yapay zeka tabanlı yöntem olan Genetik İfadeli Programlama (GEP) ve Uyarlanabilir Sinirsel-Bulanık Çıkarım Sistemi (ANFIS) kullanılarak, tahmin edilen akış değerleri gözlenen akış değerleri ile karşılaştırılmıştır. Girdi parametreleri olarak, uydu verilerinden elde edilen 4km x 4km çözünürlüklü yağış verisi kullanılmıştır. Bu yağış verisi, havza için günlük ortalama yağış yüksekliği olarak elde edilmiştir. Akım verisi olarak, Berta Suyu Havzası çıkışındaki EİE-2334 nolu akım gözlem istasyonunun (AGİ) günlük akış verileri kullanılmıştır. Akım verileri, Q(t-1), Q(t-2), Q(t-3), Q(t-4) ve yağış verileri olan P(t), P(t-1), P(t-2), P(t-3) gibi çeşitli girdi senaryoları oluşturulmuş ve çıkış olarak Q(t) ile eşleştirilmiştir. Modellerin performansı, determinasyon katsayısı (R2) ve ortalama karesel hatanın kökü (KOKH) gibi istatistiksel ölçütler kullanılarak değerlendirilmiştir. Yapılan çalışmada, ANFIS ve GEP yöntemlerinden elde edilen sonuçların birbirine yakın olduğu tespit edilmiştir. Berta Suyu Alt Havzası için en yüksek R2=0,988 ve en düşük KOKH=4,770 değerini veren modelin ANFIS-K1 olduğu görülmüştür. Bu sonuçlar, yapay zeka tekniklerinin yağış-akış ilişkisini belirlemede etkili bir araç olduğunu göstermektedir.
Analysis of World Economic Growth Using Panel Data
Authors: Njenga John K.
Published: September 2023

In this paper, I consider panel data analysis of world economies to identify the relationship between GDP growth and the independent variables, and the nature of effect that may exist. Annual data for 161 countries from 1990 to 2020 sourced from the World Bank and UN are used. GDP is the independent variable while the independent variables are population, gross value added, total natural resources rent, and labor force. Firstly, a poolability test is performed to test for the joint significance of the fixed effects. The null hypothesis is rejected as there exist significant individual effects. Secondly, Huesman’s test is performed to test for consistency of fixed effect and random effect. The null hypothesis is rejected implying significant random effects exist. Thirdly, Bruesch-Pagan test for heteroscedasticity is performed, which shows the existence of heteroscedasticity. Finally, White’s covariance matrix estimator for random effect is performed which results to consistent and efficient parameter estimate in the presence of heteroscedasticity. The random effect model is statistically significant at the 5% level, with 68 % of the variation being explained by the model. All the explanatory variables are statistically significant at a 5 % level. They all have a positive effect on GDP with the labor force and population having the highest effect. The random effect is large and significant with a variance of 2.25±1.5 and 94.1 % share of the error component. Countries that have had consistent increases in either labor force or population growth or both, has over the period experienced consistent economic growth after controlling for the other variables and the random effect.
Role of parents in hygienic and sexual education of children and adolescents
Authors: Demchenkov NO , Krasilnikova ED , Sheina NI , Korolik VV
Published: September 2023

The issue of protecting reproductive health is closely related to the childen’s and adolescents’ awareness of the negative impact of early sexual activity and pregnancy, as well as sexually transmitted diseases. At the same time, awareness of parents involved in raising children is poorly understood. The study was aimed to estimate the parents’ competence (awareness) in the field of children’s sexual and hygienic education by conducting a webinar and an online questionnaire survey. Parents were surveyed in 2022–2023. A psychologist conducted the webinar, after which the online questionnaire survey was carried out in order to assess the effectiveness of the webinar as a relevant tool to improve the parents’ competence. It was found that almost all parents believed it was necessary to discuss the issue of sexual education with children, however, among them only 64.4% actually addressed the issue. Parents had no consensus on the age of starting sexual education in children. The main difficulties in communication with children were shyness, insufficient knowledge and the lack of methods to inform the child. According to 91% of women and 66% of men, the webinar conducted by psychologist was the best method to improve the parents’ competence. It appeared to be informative for 90% of parents. The joint efforts of parents, doctors, psychologists, and teachers are the solution to the problem of sexual and hygienic education. Furthermore, informational and educational work with parents and the family is important, since the child’s sexual and hygienic education is started since early age.
前言：抗疫——在倫理道德上我們還可以做什麼？
Authors: 張 穎
Published: September 2023

三年的COVID-19疫情，對全球各國的生產生活都產生了巨大衝擊。雖然大規模的疫情已經暫時遠離我們，但有關疫情的倫理學思考並未結束。人們會問：倘若下一個疫情到來，我們在防疫上是否能夠吸取歷史的教訓，做得好些？本期的論文除了最後一篇，都出自2023年5月在香港舉辦的第十七屆"建構中國生命倫理學”研討會。論文所涉及的主題，從中國傳統醫學對疫病的認識到當今防疫、抗情中所面臨的種種倫理議題，以及如何處理普世價值與具體文化處境的關係。三年了，我們獲得了不少經驗，也有不少教訓，面對病毒對人類的挑戰，我們在倫理道德上還可以做些什麼？(撮要取自內文首段)
The use of nanorobots in the oil and gas industry
Authors: Kartoev Magomed-Amin Mikailovich , Shevyakhova Elena Andreyevna , Lyamina Natalya Fyodorovna
Published: September 2023

In order to increase oil recovery in oil fields the possibilities of using reservoir nanorobots in the oil and gas industry have been investigated. Nanorobots are micro- and nanomechanical systems capable of being injected into an oil reservoir to study and modify its properties. The main attention is paid to solving the problem of oil availability in the reservoir which is achieved by creating mechanical channels and changing the physico-chemical characteristics

of oil words, taking into account key factors - the reliability and durability of nanorobots, their ability to work in extreme field conditions. The importance of developing a specialized infrastructure for effective management and control of nanorobots, including software, as well as a communication system for data exchange between nanorobots, is emphasized. The ability of nanorobots to interact with each other and solve problems related to the optimization of oil production processes is considered. It is noted that nano-robots can be used to study and monitor the condition of wells, enhance production processes, improve the properties of materials, as well as in repair work. Before using this technology widely in the oil and gas industry, it is necessary to carry out a detailed study in order to determine the optimal methods of implementation and to solve issues of safety and reliability of such a system.
Compilation of data on optimizing tubular furnaces operation
Authors: Lysova Vera Nickolaevna , Khaibulov Rishad Abdulhakimovich
Published: September 2023

A great number of processing hydrocarbon raw material units operated at enterprises have heat exchangers of different designs. A significant share among them comes to the special heat exchangers that use the heat of exhaust gases when burning liquid and gaseous fuels – tubular furnaces. Depending on the specifics and type of fuel used, the furnaces differ both in design and in operational parameters. At AT units, AVT units, and gasoline secondary distillation units, HFC furnaces are used to heat hydrocarbon media and are characterized by heating temperatures from 300C° to 500°C. In the units of technological processes of pyrolysis, conversion of hydrocarbon gases, etc., simultaneously with heating and/or overheating of the raw materials, furnaces are used as reactors. The effective use of such furnaces is possible only if there are used engineering methods predicting changes in the technological flow, created on the basis of reliable analytical and experimental materials. The available data is insufficient to develop measures

to improve the efficiency and reliability of these units. There are discussed the results of analytical studying the optimizing the operation of tubular furnaces, identified the main disadvantages during their operation, determined methods for assessing the wear of the elements of the apparatus depending on the technological modes (temperature, pressure, medium) and the material of execution in the process of technical diagnostics of equipment to ensure industrial safety. The issues of the influence of design features and of organizing the combustion process of nozzles on the quality indicators of tubular furnaces are considered. The main directions of increasing the energy efficiency of radiant and convection chambers of tubular furnaces are defined.