bluuebunny/crossref_metadata_2025 huggingface dataset:
Of the mode and order of understanding in Summa Theologica by Thomas Aquinas: essential aspects to the master education on the medieval university
Authors: Santin Rafael Henrique , Oliveira Terezinha
Published: April 2022

Abstract The objective of the article is to analyze how Thomas Aquinas understands the procedures of the intellect to understand things inferior to the human soul, as well as the importance of knowing this process for the education of the master in Western medieval times. Our source is Question 85 of First Part of Summa Theologica, entitled ‘Of the mode and order of understanding’. This Question shows one of the main fundamentals of the Thomasian Philosophy of Education and can, in our opinion, teach important lessons for 21st century teachers. The method of research is Social History, whose theoretical principles can be found in the works by Bloch, Febvre, Braudel, and other historians, ‘heirs’ of Annales school.
Medidas de Emergência no Contexto da Covid-19
Authors: Maia Filho Mamede Said
Published: April 2022

Resumo Este artigo aborda as medidas político-jurídicas de que os Estados se valem para enfrentar as situações de crise institucional, em particular o estado de sítio e o estado de defesa, buscando demonstrar sua inadequação para o enfrentamento da Covid-19. Trata, em seguida, das medidas de emergência adotadas no Brasil por conta da crise sanitária para discutir, ao final, sua legalidade e pertinência em face das garantias constitucionais.
O direito à desconexão do trabalho francês: perspectivas de implementação no Direito brasileiro
Authors: Ponzilacqua Marcio Henrique Pereira , Silva Luana Graciana
Published: April 2022

Resumo O artigo objetiva fornecer uma análise das possibilidades de aplicação do direito à desconexão do trabalho, nos moldes da legislação trabalhista francesa, no sistema jurídico brasileiro, considerando as características sociojurídicas e culturais que culminaram na conformação atual das relações de trabalho no país. A partir disso, demonstra-se a essencialidade do direito de se desconectar no contexto do labor na Era Digital.
O trânsito de plantas: circulação de saberes e práticas médicas na América Meridional durante a Época Moderna
Authors: Gesteira Heloisa Meireles
Published: April 2022

Resumo A partir dos registros sobre plantas e ervas de médicos, agentes de cura, missionários, administradores coloniais nos séculos XVII e XVIII, o artigo explora as formas de construção do conhecimento sobre a flora, utilizando o conceito de circulação proposto por Kapil Raj. As experiências distintas e os documentos analisados demonstram o processo de observação, coleta, sistematização e circulação do conhecimento e a influência da história natural e da tradição hipocrática na classificação das ervas e plantas e na descrição adotada nos textos reunidos neste artigo. Desde livros impressos até anotações dispersas em diários de viagens, os usos das espécies para a vida humana foi o elemento valorizado por aqueles que observaram diretamente o potencial de plantas, frutos e ervas americanas.
From Dresden to the world: images of the German Hygiene Museum’s relations with Latin America, 1911-1933
Authors: Muñoz Pedro Felipe N. de
Published: April 2022

Abstract As of the nineteenth century, the number of world fairs and hygiene exhibitions grew significantly. This phenomenon was linked to the experience of modernity and the emergence of bacteriology, when different cities were sanitized with the aim of combating urban diseases and epidemics. For the purpose of sanitary education and hygiene propaganda, many objects and pictures were displayed in hygiene exhibitions and museums, such as the International Hygiene Exhibition of 1911 and the German Hygiene Museum, both in Dresden. The goal of this article is to analyze a chapter of the international history of health through images that portray the connections between the German Hygiene Museum and Latin American countries between 1911 and 1933.
Retratos do cotidiano em Manguinhos
Authors: Benchimol Jaime Larry
Published: April 2022

Resumo O texto aqui comentado reconstitui o cotidiano no Instituto Oswaldo Cruz no começo do século XX com base em depoimentos de antigos funcionários. “Os escravos são as mãos e os pés do senhor do engenho” – escreveu Antonil em 1711. Cada laboratório do instituto era como um pequeno engenho onde as mãos e os pés dos pesquisadores eram seus serventes, que executavam desde as tarefas mais desqualificadas até operações bem delicadas da pesquisa científica, atualmente confiadas a técnicos formados em escolas próprias. As habilidades dos primitivos técnicos, muitos recrutados ainda meninos nas oficinas da instituição, eram adquiridas empiricamente. O instituto era moderno por suas atividades, mas as relações de trabalho traziam as marcas de uma sociedade agrária e patriarcal, recém-egressa da escravidão.
Natureza e comércio no norte do Brasil: o “Discurso sobre os gêneros para o comércio, que há no Maranhão e Pará” de Duarte Ribeiro de Macedo (1633)
Authors: Cardoso Janaina Salvador
Published: April 2022

Resumo Dos letrados que pensaram a economia portuguesa no século XVII, talvez Duarte Ribeiro de Macedo seja o mais conhecido. Formado em direito e em filosofia, Macedo escreveu diferentes discursos sobre a introdução de manufaturas e o maior aproveitamento dos recursos naturais encontrados nas colônias portuguesas. Em seu “Discurso sobre os gêneros para o comércio, que há no Maranhão e Pará” (1633), apresentou 37 gêneros de elevado potencial econômico e que estariam disponíveis no Maranhão e no Pará. Este trabalho se dedica à transcrição desse manuscrito inédito e à apresentação das propostas de Macedo acerca das potencialidades econômicas maranhenses.
Evolução temporal e distribuição espacial da hanseníase em município de baixa endemicidade no estado de São Paulo
Authors: Ramos Antônio Carlos Vieira , Martoreli Júnior José Francisco , Berra Thaís Zamboni , Alves Yan Mathias , Barbosa Tatiana Pestana , Scholze Alessandro Rolim , Assis Ivaneliza Simionato de , Palha Pedro Fredemir , Gomes Dulce , Arcêncio Ricardo Alexandre
Published: April 2022

Resumo Objetivo Analisar a distribuição espacial e temporal da hanseníase em cenário de baixa endemicidade no estado de São Paulo, Brasil. Métodos Estudo ecológico, sobre casos de hanseníase notificados no município de Ribeirão Preto, entre 2006 e 2016. A tendência temporal da taxa de detecção de hanseníase foi verificada mediante decomposição de séries temporais, e identificadas as áreas de alta e de baixa ocorrência da doença utilizando-se a técnica Getis-Ord Gi*. Resultados Foram registrados 890 casos, e a taxa de detecção apresentou uma tendência crescente no período analisado, com crescimento médio de 1% ao mês. Identificaram-se áreas de alta ocorrência da doença na região norte do município (99% e 95% de confiança). Conclusão A taxa de detecção de hanseníase apresentou tendência temporal crescente, e a análise espacial permitiu visualizar que a região do município com maior ocorrência da doença se caracteriza por apresentar as maiores desigualdades sociais.
Endoparasite diversity and liver alterations in Hoplerythrinus unitaeniatus and Cichlasoma bimaculatum in a quilombola area in Maranhão, Brazil
Authors: Silva Ladilson Rodrigues , Monteiro Vitorya Mendes da Silva , Paiva Izabela Alves , Mendes Juliany Silva , Jesus Greiciene dos Santos de , Silva Marcelo Victor Rodrigues da , Bezerra Danilo Cutrim , Carreiro Carlos Riedel Porto , Ribeiro Larissa Sarmento dos Santos , Coimbra Viviane Correa Silva , Bezerra Nancyleni Pinto Chaves
Published: April 2022

Abstract Our aim was to assess endoparasite diversity and liver alterations in Hoplerythrinus unitaeniatus (jeju) and Cichlasoma bimaculatum (acará preto) in a quilombola area in Maranhão, Brazil. For this, 21 H. unitaeniatus and 21 C. bimaculatum were caught in a natural environment and transported to a laboratory. After these had been euthanized, endoparasites were collected and identified. Liver alterations were evaluated histological analysis based on the severity of each lesion: stage I, organ functioning not compromised; stage II, more severe lesions that impair normal functioning of the organs; and stage III, very severe and irreversible lesions. Among the fish evaluated, 71.43% H. unitaeniatus and 61.90% C. bimaculatum were parasitized. Contracaecum sp. was found in both species; while acanthocephalans, only in H. unitaeniatus. The alterations were vacuolization, nucleus in the cell periphery, deformation of the cell outline, melanomacrophage center, hyperemia, cytoplasmic degeneration and nuclear vacuolization. Through calculating a histological alteration index, it was found that 26.19% of the specimens presented lesions in stage I; 38.09% lesions in stage II and 9.52% lesions in stage III. It was concluded that there is high prevalence of Contracaecum sp. and that the liver lesions may be adaptive responses by the fish to endoparasitic infection.
Reliability assessment of reinforced slopes with unknown probability distribution
Authors: Agarwal E. , Pain A.
Published: April 2022

In the proposed study, reliability assessment of the reinforced slope (RFS) is carried out using an efficient and accurate technique of Fourth Moment Normal Transformation (FMNT). The probabilistic analysis is performed using both analytical and numerical methods. FMNT can estimate the probability of failure (Pf) of a RFS with unknown marginal distribution of input random variables. Only the first four moments of any random variable with unknown distribution are required to estimate the Pf of RFS. The use of FMNT with commercially available numerical software packages is precisely explained. The accuracy of the proposed technique, when used with different distributions of random variables, is also illustrated. The present results show considerable efficiency of FMNT in estimating the Pf when used in the analytical domain as well as with a numerical software. A detailed comparison in terms of the efficiency of the proposed formulation is also made with similar literature. FMNT is very useful for the designers to perform the reliability-based analysis of RFS. The present analytical method is also capable of incorporating the pseudo-static seismic forces into calculations.
Tests on reinforced concrete deep beams with circular and square openings
Authors: Lu Wen-Yao , Lee Tung-Ming , Lin Guo-Zhen
Published: April 2022

Eight reinforced concrete deep beams with circular or square openings were tested and the results are reported here. The main variables studied were the shape of the openings, the compressive strength of the concrete and parameters for the horizontal stirrups. The test results show that the shear strengths of deep beams made with high-strength concrete were higher than the shear strengths of deep beams made with normal-strength concrete. In addition, the shear strengths of deep beams with circular openings were found to be higher than those of deep beams with square openings. The first inclined cracking loads of the deep beams with circular openings were larger than those of the beams with square openings. The shear strengths of deep beams with horizontal stirrups were higher than those of deep beams without horizontal stirrups. Horizontal steel bars on top of the openings were found to be very important for the design of deep beams. A previously proposed softened strut-and-tie model was used to calculate the shear strengths of reinforced concrete deep beams with circular, rectangular and square openings. Comparison of the results proved the accuracy of the softened strut-and-tie model.
Fabrication of superhydrophobic PDMS/TiO2 composite coatings with corrosion resistance
Authors: Zhou Zhangyan , Ma Beiyue , Zhang Xin , Deng Chengji , Yang Shujie , Hu Chuanbo
Published: April 2022

In this study, a combination of hydrothermal and sol–gel methods was used to prepare superhydrophobic polydimethylsiloxane (PDMS)/titanium dioxide (TiO2) composite coatings with good self-cleaning properties and corrosion resistance. The structural, surface roughness and wettability behavior of the PDMS/titanium dioxide superhydrophobic coatings were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, atomic force microscopy and contact angle measurements. The results showed that the surfaces of composite coatings possessed rough hierarchical micro/nanostructures. In particular, the surface water contact angle is as high as 160° and the sliding angle is less than 2.1° when the ratio of PDMS/titanium dioxide was 1:5. Besides, through a series of high-temperature exposure, acid–alkali resistance, self-cleaning and electrochemical corrosion tests, it was found that the superhydrophobic surface with a PDMS/titanium dioxide ratio of 1:5 had excellent properties and showed certain practicability in terms of anticorrosion properties, antipollution properties and durability. Therefore, it can be concluded that this kind of corrosion-resistant superhydrophobic PDMS/titanium dioxide composite coating with simple operation, high performance and multi-scale use on metal substrates has good application prospects in harsh environments.
Anticorrosion and surface evaluation of Ni–Co–TiO2coatings in 3.5 wt.% NaCl solutions
Authors: Hashem Mahmoud Nady , Negem Mosaad Ragab , El-Katori Emad El-Din
Published: April 2022

Herein, the authors are interested to provide the synthetic methodologies, chemical properties and the corrosion performance of some Ni–xCo–yTiO2nanocomposite electroplated on copper (Cu) using a gluconate–cysteine bath, pointing at the classification of these materials corresponding to their stability in that simulated marine solution, and recommend using these materials in such aggressive media. Electrochemical and spectroscopic measurements were carried out in 3.5 wt.% sodium chloride (NaCl) electrolytes at 25°C. The electrochemical properties of the applicable nanocomposite material were studied to enhance manufacturing technology and forecast the stability of structures made from it. The produced nanocomposite coatings were demonstrated to have high corrosion resistance in the investigated electrolyte, which is commonly utilized in hydrogen evolution reaction applications and corrosion investigations of other novel materials. By characterizing the corrosion performance of the examined Ni–xCo–yTiO2nanocomposite coatings in 3.5 wt.% sodium chloride solution, Ni–48Co–3.8TiO2is regarded as the most stable electrode. The results showed that the inclusion of cobalt (Co) in Ni–xCo–yTiO2significantly lowered the corrosion rate of the investigated composites. The surface examination revealed the presence of several material constituents in the passive layer. Density functional theory and Monte Carlo simulation approaches were used to investigate and analyze the relationship between molecular structure and inhibitory effect.
Proposed method for determining the population carrying capacity of cities: the city-mass index
Authors: Özdemir Murat , Ayataç Hatice , Cenan İnce E.
Published: April 2022

Increasing urbanisation has led to changes in the population distribution in cities and, thus, unbalanced urban development. This study aimed to estimate the current population loads of cities by determining the balanced distribution of a country's population on the basis of the natural, physical and sectoral factors in cities. The study was informed by the following perspective: cities are not independent structures. They belong to an ecosystem that includes the other cities in the country; thus, their share of the population should be in accordance with their stiffness calculated from its natural, physical and sectoral factors. An outcome of the study is to suggest the city-mass index model, which is inspired by the body mass index, to estimate the population loads of cities. The theoretical model, whose effectiveness was confirmed by the results of the analytical hierarchical process, was tested in Turkey and converted into concrete outputs.
"'A Certain Enemy Robbed Me of My Life': Medieval Riddles, Digital Transformations, and Pandemic Pedagogy"
Authors: Bolintineanu Alexandra , Henderson C. E. M. , Alves Wong Ana Algarvio , Cho Dionysus , Carino Robyn Jane , Du Kathy
Published: April 2022

This essay examines a Fall 2020 assignment for a second-year undergraduate “Introduction to Digital Humanities” course as a case study of digital experiential learning during the Covid-19 pandemic.

The essay is a collaboration between the course instructor (Bolintineanu) and teaching assistant (Henderson), with our student game creators (Alves, Carino, Cho, Du). We situate the assignment, which invites students to transform a medieval riddle into a Twine game, within Digital Humanities (DH) Inquiry-Based Learning (IBL), at the crossroads of archive-centred learning and critical making; and we examine contributions by four student game creators within the pedagogical poetics of the early medieval riddle tradition.
Investor Base and Prime Money Market Fund Behavior
Authors: Li Lei , Epstein Lucas
Published: April 2022

Prime money market funds (MMFs) represent a key vulnerability in the financial system. During the last 15 years, they have experienced two severe investor runs, in September 2008 and March 2020, both of which contributed to full-scale financial crises.
Spread Too Thin: The Impact of Lean Inventories
Authors: Ortiz Julio L.
Published: April 2022

Widespread adoption of just-in-time (JIT) production has reduced inventory holdings. This paper finds that JIT creates a trade-off between firm profitability and vulnerability to large shocks. Empirically, JIT adopters experience higher sales and less volatility while also exhibiting heightened cyclicality and sensitivity to natural disasters. I explain these facts in a structurally estimated general equilibrium model where firms can adopt JIT. Relative to a no-JIT economy, the estimated model implies a 1.3% increase in firm value. At the same time, an unanticipated shock results in a roughly 15% deeper output contraction. This occurs because firms "stock out" or hoard materials.
OS PRODUTORES DE ALFAFA E SUAS UNIDADES DE PRODUÇÃO FAMILIAR: UM ESTUDO EM DEZESSEIS DE NOVEMBRO/RS
Authors: Barros Tatiane Fenner de , Anes Carlos Eduardo Ruschel , Dalcin Dionéia
Published: April 2022

A agricultura é um segmento essencial para a geração de emprego e renda no meio rural. Com isso em vista, o presente artigo tem como objetivo analisar os produtores de alfafa e suas unidades de produção no município de Dezesseis de Novembro/RS. Em relação à abordagem metodológica, este estudo pode ser classificado como uma pesquisa qualitativa, baseada no método descritivo. O instrumento de coleta de dados consistiu em um roteiro de entrevista semiestruturado, aplicados para uma amostra de 15 produtores de alfafa do município de Dezesseis de Novembro/RS, em suas Unidades de Produção Familiar. Para a etapa de análise de dados, a técnica de estatística descritiva foi utilizada. Os resultados demonstram que os entrevistados estão em propriedades com até 40 hectares de terras (70%); a mão de obra predominante é a familiar e diarista e a renda bruta das famílias entrevistadas (80%), por sua vez, varia entre 2 e 10 salários mínimos. A alfafa é produzida em todas as propriedades e há a diversificação na produção. Em sua maioria, a gestão das propriedades é de responsabilidade masculina, sendo sua principal ocupação a Agricultura, e sua faixa etária variando entre os 31 e 60 anos (70% dos entrevistados). Além disso, a pesquisa evidenciou a necessidade de novos estudos sobre outros temas relativos ao meio analisado, a saber: a saída dos jovens do meio rural em Dezesseis de Novembro, o envelhecimento da população e a preocupação com a sucessão familiar e o trabalho feminino nas famílias de produtores de alfafa do município.
OS RISCOS SOBRE O AUMENTO DOS CASOS DE SUICÍDIO NO CONTEXTO DE PANDEMIA: Perspectivas para a prevenção no estado do Rio Grande do Sul - Brasil
Authors: Junior Carlos Stavizki
Published: April 2022

Neste artigo analisa-se a questão do suicídio no Brasil e no estado do Rio Grande do Sul, destacando quais os efeitos que a pandemia de SARS-CoV-2 traz para a discussão e prevenção desta problemática no contexto atual. Estima-se que o aumento do desemprego e a precarização das relações de trabalho, somados a políticas econômicas neoliberais, influenciem no aumento de casos de suicídio no país. A partir da revisão bibliográfica sobre a relação de dados socioeconômicos, culturais e regionais nos índices de suicídio, apresenta-se considerações e perspectivas capazes de auxiliar na prevenção dos casos. Conclui-se que as políticas de redistribuição de renda, aliadas a ampliação e fortalecimento das políticas de saúde mental, tendem a prevenir o aumento de mortes autoprovocadas no território.
O turismo gastronómico e a gestão de eventos: um contributo para o desenvolvimento local
Authors: Fernandes José Miguel , Sousa Bruno Barbosa
Published: April 2022

Nos últimos anos a gestão do território enquanto marca através da utilização de ferramentas de marketing até aqui usadas pelas empresas tem vindo a ganhar relevo. É notória a importância do turismo como dinamizador e impulsionador das economias, tanto nacionais como regionais e/ou locais. Atendendo à relevância do turismo, nomeadamente o turismo gastronómico (na divulgação e promoção de tantas regiões) a presente investigação está fortemente centrada neste segmento turístico. Consideramos ajustado, percecionar de que forma a afetividade dos residentes para com a gastronomia local, serão ou não fatores determinantes na valorização dos territórios. Neste estudo, procurar-se-á compreender junto da população local (nomeadamente a população residente no município de Penafiel) qual o seu papel na dinamização deste tipo de turístico. Procura-se, também, aferir o grau de afetividade dos residentes para com a gastronomia local, nomeadamente com uma das iguarias presentes no território, a lampreia (i.e. perspetiva de turismo e hospitalidade). Assim, no percurso desde estudo, iremos procurar percecionar o grau de identificação afetiva da população de Penafiel com a lampreia, lampreia como produto gastronómico, e de que forma o Festival da Lampreia (FL) é importante para a população Penafidelense, nomeadamente, e aos olhos dos agentes locais, se este contribui para o desenvolvimento do concelho de Penafiel e como potenciador da economia local. Foi levada a cabo uma investigação de natureza qualitativa, nomeadamente com recurso a entrevistas semiestruturadas e um focus group. Os resultados demonstram que o papel dos residentes é preponderante no que concerne ao sucesso do turismo gastronómico do território numa lógica de desenvolvimento regional. Em específico, os resultados parecem evidenciar uma forte afetividade por parte dos residentes, sendo que a mesma poderá ser aproveitada numa vertente de marketing de lugares e comunicação territorial. Numa perspetiva interdisciplinar, o presente estudo apresenta inputs para o marketing (de lugares), para o turismo e para o desenvolvimento local (e.g. eventos turísticos ou gastronómicos). No final, são apresentadas algumas limitações do estudo e delineadas as próximas linhas de investigação.
BUSINESS MODEL "PERFORMANCE INDICATORS OF THE EMPLOYEE OF THE ORGANIZATION" ON THE EXAMPLE OF JSC "SMP BANK"
Authors:   Ufa State Petroleum Technological University, Khisaeva A.I , Mazitova K.A. ,   Ufa State Petroleum Technological University
Published: April 2022

Businesses and organizations set goals to achieve results and meet the needs of interested parties. These goals start at the top and reach every team in the organization, each with unique roles to drive the business. There are many different ways to set and measure goals. One of the popular ways to measure the progress of an individual, team, or company towards a goal is to use Key Performance Indicators or KPIs. Key performance indicators are a set of interrelated indicators used by modern companies for effective management and implementation of the strategic and tactical goals of the organization. The conscious choice of KPIs is based on an understanding of their variety and features of their use in certain managerial situations. This allows you to develop a truly balanced scorecard that provides the shortest path to achieving the strategic goals of the enterprise. The relevance of the topic is due to the fact that KPIs help companies understand whether they are spending their time, budget and talents on their goals and whether strategies, objectives and tools have been developed to achieve these goals. When KPIs are introduced, the motivation system becomes clear and transparent: since planned and actual values are recorded, it is clear to the manager why and how to motivate the employee. To calculate the efficiency of each employee, a business model “Application for accounting of key performance indicators of an employee of an organization” was proposed using the example of JSC “SMP Bank”. Since JSC "SMP Bank" not so long ago began to promote its mortgage products, a new mortgage lending department was organized. This department has the functionality of nicknameing clients and making applications. Employees have no idea for what they will be credited with motivations, how the implementation of the set plan will be recorded. This article is devoted to the solution of this problem.
[RETRACTED] Goddess Molecule Complex - “Skinny After 30” program over the long-term? (Focus on your health, and lead a more active lifestyle) v1
Authors: Molecule Complex Goddess
Published: April 2022

[RETRACTED]

Goddess Molecule Complex - “Skinny After 30” program over the long-term? (Focus on your health, and lead a more active lifestyle)
[RETRACTED] Willie Nelson CBD Gummies v1
Authors: not provided barllywild
Published: April 2022

[RETRACTED]

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Biopolymers as Multiplatform Materials to Improve Quality of Life and Well-Being
Authors:   Federal University of Rio de Janeiro, de Souza Jr Fernando Gomes
Published: April 2022

Biopolymers are all the macromolecular materials formed in nature or produced using bio-monomers. Biopolymers are extremely diverse materials, which have unique properties. Unfortunately, the general cost of biopolymers production is about 25 % higher compared to similar materials from petrochemical sources. Therefore, scientists must continuously pursue the search for differentiated applications for these materials. These new applications, especially those with enhanced added value, are essential for extending the use of these unique materials. In this context, the Biopolymers & Sensors Lab. (LaBioS) of the Federal University of Rio de Janeiro has been operating since 2008 in research related to the production of biopolymers. LaBioS works on the chemical modification and the nanomodification of these biopolymers. These were the strategies found by the group to increase the added value of these systems, allowing their use in several applications that positively impact human well-being. Therefore, we dedicate this work to describing the state of the art in biopolymers via text mining study of the content produced on this great subject from the year 2008 to the year 2021. In addition, we present here short case studies developed by the team that currently composes LaBioS. These cases cover several areas, ranging from drug release, through environmental recovery, to food security
Aloe vera Incorporated Chitosan/Nanocellulose Hybrid Nanocomposites as Potential Edible Coating Material under Humid Conditions
Authors:   Czech Technical University, Sali Anjumol Kidangayil
Published: April 2022

Innovative post-harvest technologies are in demand to meet the requirements of farmers and agricultural industries to ensure global food security and to avoid food wastage. Edible coatings that can prevent food spoilage and/or enhance shelf life have taken on increasing importance. This work involves the development of edible coatings based on easily available bio resources, chitosan and nanocellulose, and utilizing their unique properties as an effective coating material. Aloe vera, known for its antioxidant and antimicrobial properties, has been proposed as an active ingredient that can be incorporated into the biodegradable film. Varying volumes of Aloe vera (0.25 ml, 0.35 ml, 0.5 ml, and 2.5 ml) were added to fabricate nanocomposite films by solvent casting. Transparent films were obtained, and their morphology was analysed using scanning electron microscope (SEM). The incorporation of Aloe vera was confirmed in various spectroscopic studies, which clearly show reduction in light transmittance for the nanocomposite films containing Aloe vera. The contact angle study showed an increase in hydrophobicity initially. Maximum tensile strength was obtained with 0.25 ml of Aloe vera. The potential use of nanocomposite solution as edible films was demonstrated in green chillies, which showed lower weight loss after 3 days when compared with uncoated chillies. In the first phase of this study, chitosan/nanocellulose nanocomposites enriched with Aloe vera have been proposed as a potential edible food coating material
Casein Stabilized Metal and Metal Oxide Nanoparticles for the Efficient In Vitro Culturing of Scoparia dulcis L.
Authors:   Mahatma Gandhi University, Rakhimol Kalathil Rajan
Published: April 2022

Unique physicochemical properties of nanoparticles make them a novel candidate in agriculture and related areas. In the present work, we have studied the effect of casein stabilized metal and metal oxide nanoparticles, viz. AgNPs, AuNPs, and CuONPs, on in vitro propagation of Scoparia dulcis L. We have examined the effect of these nanoparticles on the callus induction, shoot regeneration, and root regeneration capacity. It was observed that Ag, Au, and CuO nanoparticles had interacted with the tissues differently and produced calluses with difference in color, nature, and texture. Nanoparticles also affected shoot regeneration, root regeneration, phenolic compound production, and chlorophyll content. Explants showed a very good response when treated with CuONPs. The formed callus underwent shoot and root regeneration without changing the medium
Treatment of Non-Healing Trophic Ulcers in Patients with Chronic Venous Insufficiency Using Wound Coatings Based on Bacterial Cellulose Loaded with Silver Nanoparticles
Authors:   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Vinnik Yuri S.
Published: April 2022

Chronic venous insufficiency is a common condition that affects people of different ages. Trophic ulcers are a complication of venous insufficiency which is difficult to treat. Therefore, development of new, combined methods of treatment using coatings that have both antibacterial and wound healing properties is a topical issue. The article presents a comparative analysis of clinical trials of wound coatings based on bacterial cellulose (experimental group 1), cellulose loaded with silver (experimental group 2), and «Hydrocall» (control group) in treatment of trophic ulcers in patients with chronic venous insufficiency. Application of all types of wound coatings demonstrated a positive dynamics of healing. Complete epithelialization was observed in experimental group 2 by the 42nd day, whereas in patients of the control group, epithelialisation was not complete by the 45th day. Thus, application of wound coatings based on cellulose loaded with silver shortened the epithelialisation process and trophic ulcers healing, which justifies to their efficiency and practicality
Immuno-oncological drugs application in the treatment of metastatic cutaneous melanoma with lymph nodes metastases of rare localization: a case report
Authors: Polyakov A. P. , Bolotina L. V. , Kornietskaya A. L. , Kudashkina D. S. , Sidorov D. V. , Troitskiy A. A. , Gevorkov A. R.
Published: April 2022

Cutaneous melanoma is characterized by an aggressive course associated with a tendency to metastasis. For a long time, the prognosis of patients with metastatic melanoma remained extremely poor. However, the introduction of immunooncological drugs into clinical practice has changed the approaches to the treatment of patients with metastatic melanoma, and fundamentally improved the prognosis and quality of life of such patients, which undoubtedly became a breakthrough in the treatment of this pathology. This article presents a clinical case of the treatment with immunological drugs of a patient with metastatic melanoma of the skin with lymph nodes of rare localization with a complete tumor response.
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Authors: Editorial Article
Published: April 2022

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Surgical treatment of patients with cerebral metastases in the motor area
Authors: Belov D. M. , Karakhan V. B. , Bekyashev A. Кh. , Sevyan N. V. , Aleshin V. A. , Mitrofanov A. A. , Prozorenko E. V. , Sashin D. V. , Garanina N. V.
Published: April 2022

Introduction. The surgical stage takes an important place in the complex treatment of patients with cerebral metastases of malignant tumors. In general, all efforts during surgical intervention should be aimed at restoring a good functional status, since severe neurological symptoms can deprive patients of the opportunity to continue complex treatment, which will negatively affect overall survival. The most pronounced neurological symptoms are observed in patients with metastases in the motor area. In this article, we tried to substantiate the need for surgery of cerebral metastases in patients with severe motor deficits, evaluate the results of surgical treatment and also to develop optimal surgical removal techniques.

The study object – to assess the effectiveness of surgical removal of metastases in the motor cortex by evaluating the dynamics of motor function recovery and regression of paroxysmal symptoms.

Materials and methods. An analysis of the surgical treatment of 18 patients with metastases in the motor area was carried out. Tumor localization was verified using magnetic resonance imaging, before surgery, neuronavigation system Brainlab during surgery. Мagnetic resonance tractography made it possible to assess the localization and degree of compression of the fibers of the cortico-spinal tract. Functional monitoring was not performed during the operation. The operations were performed using a ZEISS OPMI PENTERO 800 microscope.

Results. Recovery of motor function after surgery was noted in 17 (94.5 %) cases. It was complete or partial. With metastases of a solid, solid-necrotic, solid-cystic structure, regression of pyramidal symptoms developed gradually, starting from 4 days after surgery. As a rule, rehabilitation therapy (therapeutic exercise, massage, electromyostimulation) is carried out on patients from 3 days after surgery, which accelerated the recovery process. The maximum effect developed on the 15th day after the operation. Faster recovery of motor function was observed in patients with large cystic metastases who underwent surgery in the volume of Ommaya reservoir implantation. They began to recover motor function a few hours after awakening. Regression of paroxysmal symptoms was noted in all cases. Although the patients continued to take anticonvulsants. The observation period was 6 months.

Сonclusion. Surgical removal of cerebral metastases in the motor area allows achieving complete or partial regression of neurological symptoms. At the same time, the recovery period is short – from several hours to 14 days. It becomes possible to cancel glucocorticoids 7–10 days after the operation. Conditions are being created for the continuation of complex treatment of patients previously considered incurable.
Rational sequence of monoclonal antibodies in the treatment of non-resectable head and neck squamous cell carcinoma
Authors: Bolotina L. V. , Ustinova T. V. , Dеshkina T. I. , Golubev P. V. , Lyubavina N. N. , Fedenko A. A. , Kaprin A. D.
Published: April 2022

This article discusses current approaches to first-line chemotherapy for non-resectable head and neck squamous cell carcinoma and describes factors affecting the choice of treatment regimen according to the results of randomized clinical trials. We provide a rationale for creating a long-term strategy of chemotherapy in different clinical situations. We also report two cases of concomitant administration of cetuximab and platinum-based therapy as an example of high efficacy of monoclonal antibodies.
Prevalence and organization problems of medical care to patients with precanceral oral cavity mucosa diseases (on the Tomsk Region example)
Authors: Mikhalev D. E. , Baydik O. D. , Mukhamedov M. R. , Sysolyatin P. G.
Published: April 2022

Introduction.Nowadays discussed and actual issues of modern oncology are the diagnostics problems and care organization for patients with oral mucosa and lips precancerous diseases.

Study purposes– to analyze the prevalence, structure, and primary diagnosis quality of oral mucosa and lips precancerous diseases and to identify the organizing medical care problems for the adult population with the oral cavity precancerous diseases in residents of Tomsk city and Tomsk Region.

Materials and methods.For the period 2014–2019 1,664 patients were examined and treated for oral mucosa and lips diseases. The main complaints and medical history were clarified in all patients, according to the recommendations of the World Health Organization, assessed the state of the oral mucosa and lips according to the visual inspection data. To assess the primary diagnosis quality of an oral mucosa disease, we analyzed the data from a dental patient’s medical record, dentist’s referrals, and anamnesis data.

Results.In the general oral mucosa and lips pathology structure almost a quarter (25.7 %) of patients were diagnosed with precancerous diseases – leukoplakia (12.5 %), lichen planus (10.8 %), viral papillomas (2.0 %) and Manganotti cheilitis (0.4 %). Malignant neoplasms of the oral cavity at different stages was established in 8.3 % of cases. A retrospective errors analysis revealed that in 100 % of leukoplakia, lichen planus, candidiasis and stomatitis cases the disease form was not indicated. In 22 % cases out of the total number of oral leukoplakia patients, the diagnosis was made mistakenly. In 12 cases of malignant neoplasm underdiagnoses, lichen planus and oral mucosa candidiasis prevailed. In half of the cases of the mistakenly diagnosed oral leukoplakia (10.2 %), oral cavity squamous cell carcinoma was detected. The average waiting time for the oncologist»s appointment was 44.3 ± 10 days.

Conclusion.The results indicate a high prevalence of precancerous pathology in the oral mucosa structure diseases

(25.7 %) and a long wait for specialized medical care.
A randomized study to evaluate the safety and efficacy of two dosages of lenvatinib – 18 and 24 mg – in patients with radioiodrefract differentiated thyroid cancer
Authors: Brose M. S. , Panaseykin Yu. , Konda B. , De la Fouchardiere C. , Hughes B. G.M. , Gianoukakis A. G. , Park Y. J. , Romanov I. , Krzyzanowska M. K. , Leboulleux S. , Binder T. A. , Dutcus C. , Xie R. , Taylor M. H.
Published: April 2022

Введение. Ленватиниб является мультикиназным ингибитором, одобренным для лечения радиойодрефрактерного дифференцированного рака щитовидной железы (РЙР-ДРЩЖ) в стартовой дозе 24 мг / день. Данное двойное слепое исследование было проведено с целью определения, будет ли использование ленватиниба в стартовой дозе 18 мг / день наряду со снижением токсичности обеспечивать такую же эффективность, как и его применение в дозе 24 мг / день.

Методы. Пациенты с РЙР-ДРЩЖ были рандомизированы в 2 группы в соответствии с дозировкой ленватиниба: 24 и 18 мг / день. Первичной конечной точкой эффективности была частота объективного ответа через 24 нед (ЧОО24 нед). Границей эквивалентности было принято значение 0,4. Первичной конечной точкой безопасности была частота тяжелых (III степени тяжести и выше) нежелательных явлений, возникших после начала лечения (НЯП), по состоянию на 24‑ю неделю. Опухоли оценивались с помощью Критериев оценки ответа солидных опухолей, версия 1.1 (Response Evaluation Criteria In Solid Tumors version 1.1, RECIST 1.1). Нежелательные явления, возникшие после начала лечения, тщательно мониторировались и регистрировались.

Результаты. Частота объективного ответа через 24 нед в группе применения ленватиниба в дозе 24 мг / сут составила 57,3 % (95 % доверительный интервал (ДИ) 46,1–68,5), в группе применения ленватиниба в дозе 18 мг / сут – 40,3 % (95 % ДИ 29,3–51,2); отношение шансов (18 / 24 мг) 0,50 (95 % ДИ 0,26–0,96). К 24‑й неделе серьезные НЯП, возникшие после начала лечения, были зафиксированы у 61,3 % пациентов в группе применения ленватиниба в дозе 24 мг / сут и у 57,1 % в группе применения ленватиниба в дозе 18 мг / сут. Разница составила –4,2 % (95 % ДИ 19,8–11,4).

Заключение. Использование стартовой дозы ленватиниба 18 мг / сут не продемонстрировало эквивалентной эффективности по сравнению с использованием стартовой дозы 24 мг / сут, что подтверждено показателями ЧОО24 нед у пациентов с РЙР-ДРЩЖ. Была выявлена клинически значимая разница в Ч ОО24 нед. Профили безопасности 2 дозировок ленватиниба были сопоставимыми, клинически значимых различий не наблюдалось. Полученные результаты подтверждают оправданность утвержденной стартовой дозы ленватиниба 24 мг / сут у пациентов с РЙР-ДРЩЖ и дальнейшей ее корректировки по мере необходимости.
INTERPRETATION OF THE 3D GEOELECTRICAL MODEL OF THE STEPPE CRIMEA BOWELS. EUPATORIA AND SAKI PROFILES
Authors:   Institute of Geophysics NAS of Ukrane, Burakhovich T. , Kushnir A. ,   Institute of Geophysics NAS of Ukrane, Ilienko V. ,   Institute of Geophysics NAS of Ukrane
Published: April 2022

The interpretation of the segment of the deep three-dimensional Crimean region geoelectrical model within the Saki and Yevpatoria profiles, built on the basis of the Earth's low-frequency electromagnetic field experimental observations, was obtained in 2012 by the INSTITUTE OF GEOPHYSICS named after S.I.Subbotin. The main result of the analysis is the identification of vertical and horizontal alternation of high and low resistivity, both in the earth's crust and in the upper mantle. It is shown that the geoelectrical sections along all the profile sections of the model are characterized by a dip to the north of the consolidated basement surface depth and, accordingly, an increase of the near-surface layer conductivity. The conductivity anomaly in the consolidated earth's crust was revealed in the depth interval of 5-10 km with resistivity (ρ) of 5 Ohmꞏm, galvanically connected with the sedimentary cover. Deeper than 10 km, homogeneous and inhomogeneous layers in ρ alternate: 10-60 km with ρ = 1000 Ohmꞏm; 60-90 km with ρ = 100 and 1000 Ohmꞏm; 90-110 km with ρ = 1000 Ohmꞏm; 110-140 km with ρ = 40 and 1000 Ohmꞏm, the contact corresponds to the different ρ of normal geoelectrical sections of different-aged structures of the Scythian plate and the East European platform; also horizontally layered normal section. It has been analyzed that earthquake sources of the Steppe Crimea seismic region are concentrated in geoelectrically inhomogeneous zones and tend to contact structures with ρ differ - above the upper margin, outside and between the conductivity anomalies in the consolidated rocks of the earth's crust. The considered material confidently indicates the confinement of hydrocarbon manifestations to the high electrical conductivity anomalies identified according to the data of geoelectromagnetical sounding and three-dimensional modeling, which are characterized by subvertical channels galvanically connected with sedimentary deposits, and layering in the earth's crust and upper mantle. Geoelectrical inhomogeneities, which reflect the current state of the earth's crust and upper mantle and are probably due to the influence of modern mantle fluids, correspond to manifestations of seismicity and hydrocarbon content.
INTRUSIVE-MAGMATIC COMPLEXES OF WILHELM ARCHIPELAGO, WEST ANTARCTICA (PART 1 – INTRUSIONS OF GABBROIDS, DIORITES AND GRANITOIDS)
Authors:   Badji Mokhtar University, Mekti Z. , Boutemedjet A. ,   Badji Mokhtar University, Sekiou O. ,   Environmental Research Center (C.R.E), Annaba, Algeria, Berdoudi S. ,   Badji Mokhtar University, Chaib A. ,   Badji Mokhtar University, Kouider F. ,   SEGi University, Malaysia, Rahmani A. ,   SEGi University, Malaysia, Benselhoub A. ,   Environmental Research Center (C.R.E), Annaba, Algeria
Published: April 2022

For several decades, airborne particulate matter (PM) pollution has become one of the major concerns of policymakers across the globe, due to its adverse effects on climate, human health, environment and various socio-economic sectors. The process of phosphate export in bulk is one of the main source generating air pollutants, such as PM emissions of different shapes, concentrations and particle sizes, which can cause respiratory diseases. The objective of this work is to determine the dust level generated by the processes of unloading, storage and loading of phosphate in bulk to ships, by the company of the port installation at the port of Annaba (East of Algeria). The PM measurement campaign was carried out according to the NF X 43-014. It was performed on 08 sampling points located at the port of Annaba and in a periphery with a radius of up to 2.3 km. The recorded results show very high levels of dust in 05 samples series largely exceeding the acceptable threshold (1000 mg/m²/day). The level of heavy metals in dust was evaluated by the analysis of Atomic Absorption Spectrometry. EDAX analysis showed that the phosphate PM have an angular morphology elongated particles and hook-shaped.
STUDYING SWELLING SOILS BY MULTIDIMENSIONAL STATISTICAL ANALYSIS METHODS AS THE BASIS FOR ENGINEERING STRUCTURES FOUNDATIONS IN SUDAN
Authors:   Taras Shevchenko National University of Kyiv, Chomko D. , Chomko F. ,   V.N. Karazin Kharkiv National University, Cherkashyna N. ,   V.N. Karazin Kharkiv National University, Taranov V. ,   O.V. Beketov Kharkiv National University of Municipal Economy, School of Geotechnics, Seifeldin G. ,   Khartoum University, Sudan
Published: April 2022

A new way to study swollen soils as the basis for foundations by methods of mathematical statistics, including cluster, factor and correlation-regression analyses has been proposed in the article. Normative values of the strength characteristics of these soils depending on their physical properties and degree of swelling, application limits, predominant factors and correlations between different indicators of soil properties have been established according to the results of these analyzes. A method of the study area zoning, leading to possible differential application of soils normative characteristics, as well as proposals for designing foundations on swollen soils have been developed. The methods were tested on the soils of Sudan.