bluuebunny/crossref_metadata_2025 huggingface dataset:
A Design for Addressing Multiple Ecosystem Services in Forest Management Planning
Authors: Baskent Emin Zeki , Borges José Guilherme , Kašpar Jan , Tahri Meryem
Published: October 2020

Forest policy and decision-makers are challenged by the need to balance the increasing demand for multiple ecosystem services while addressing the impacts of natural disturbances (e.g., wildfires, droughts, wind, insect attacks) and global change scenarios (e.g., climate change) on its potential supply. This challenge motivates the development of a framework for incorporating concerns with a wide range of ecosystem services in multiple criteria management planning contexts. Thus, the paper focused on both the analysis of the current state-of-the art research in forest management planning and the development of a conceptual framework to accommodate various components in a forest management process. On the basis of a thorough recent classification of forest management planning problems and the state-of-the-art research, we defined the key dimensions of the framework and the process. The emphasis was on helping to identify how concerns with a wide range of ecosystem services may be analyzed and better understood by forest ecosystem management planning. This research discusses the potential of contemporary management planning approaches to address multiple forest ecosystem services. It highlights the need for a multi-level perspective and appropriate spatial resolution to integrate multiple ecosystem services. It discusses the importance of methods and tools that may help support stakeholders’ involvement and public participation in hierarchical planning processes. The research addresses the need of methods and tools that may encapsulate the ecological, economic, and social complexity of forest ecosystem management to provide an efficient plan, information about tradeoffs between ecosystem services, and the sensitivity of the plan to uncertain parameters (e.g., prices, climate change) on time.
Soil Fungal Communities under Pinus patula Schiede ex Schltdl. & Cham. Plantation Forests of Different Ages in Ethiopia
Authors: Alem Demelash , Dejene Tatek , Oria-de-Rueda Juan Andrés , Geml József , Martín-Pinto Pablo
Published: October 2020

The cultivation of plantation forests is likely to change the diversity and composition of soil fungal communities. At present, there is scant information about these communities in Ethiopian plantation forest systems. We assessed the soil fungal communities in Pinus patula Schiede ex Schltdl. & Cham. stands aged 5, 11, or 36-years-old using DNA metabarcoding of ITS2 amplicons. The ecological conditions of each plot, such as climate, altitude, and soil, were similar. Stand age and soil fertility influenced soil fungal species diversity and ecological guilds. In total, 2262 fungal operational taxonomic units were identified, of which 2% were ectomycorrhizal (ECM). The diversity of ECM fungi was higher in the 5 and 36-year-old stands than in the 11-year-old P. patula stands. Contrary to our expectations, a high level of ECM species diversity was observed in young stands, suggesting that these ECM species could compensate for the effects of nutrient stress in these stands. Our results also suggested that the abundance of plant pathogens and saprotrophs was not affected by stand age. This study provides baseline information about fungal community changes across tree stands of different ages in P. patula plantations in Ethiopia that are likely related to ECM fungi in young stands where relatively low soil fertility prevails. However, given that the plots were established in a single stand for each age class for each treatment, this study should be considered as a case study and, therefore, caution should be exercised when applying the conclusions to other stands.
Experimental Investigation of Transverse Loading Behavior of Ultra-High Molecular Weight Polyethylene Yarns
Authors: Shah Karan , Sockalingam Subramani
Published: October 2020

Ultra-high molecular weight polyethylene (UHMWPE) Dyneema® SK-76 fibers are widely used in personnel protection systems. Transverse ballistic impact onto these fibers results in complex multiaxial deformation modes such as axial tension, axial compression, transverse compression, and transverse shear. Previous experimental studies on single fibers have shown a degradation of tensile failure strain due to the presence of such multi-axial deformation modes. In this work, we study the presence and effects of such multi-axial stress-states on Dyneema® SK-76 yarns via transverse loading experiments. Quasi-static transverse loading experiments are conducted on Dyneema® SK-76 single yarn at different starting angles (5°, 10°, 15°, and 25°) and via four different indenter geometries: round (radius of curvature (ROC) = 3.8 mm), 200-micron, 20-micron, and razor blade (ROC ~2 micron). Additionally, transverse loading experiments were also conducted for a 0.30 cal. fragment simulating projectile (FSP) and compared to other indenters. Experimental results show that for the round, 200-micron indenter, and FSP geometry the yarn fails in tension with no degradation in axial failure strain compared to the uniaxial tensile failure strain of SK-76 yarn (2.58%). Whereas for the 20-micron indenter and razor blade, fibers fail progressively in transverse shear followed by progressive strength degradation of the yarn. Strength degradation of yarn occurs at relatively low strains of 0.6–0.7% with eventual failure of the yarn at approximately ~1.8% and ~1.5% strain for the 20-micron indenter and razor blade, respectively. Breaking angles (range of 10°–30°) are observed to have little effect on the failure strain for all indenter geometries.
The Freeze-Drying of Foods—The Characteristic of the Process Course and the Effect of Its Parameters on the Physical Properties of Food Materials
Authors: Nowak Dorota , Jakubczyk Ewa
Published: October 2020

Freeze-drying, also known as lyophilization, is a process in which water in the form of ice under low pressure is removed from a material by sublimation. This process has found many applications for the production of high quality food and pharmaceuticals. The main steps of the freeze-drying process, such as the freezing of the product and primary and secondary drying, are described in this paper. The problems and mechanisms of each step of the freeze-drying process are also analyzed. The methods necessary for the selection of the primary and secondary end processes are characterized. The review contains a description of the effects of process conditions and the selected physical properties of freeze-dried materials, such as structural properties (shrinkage and density porosity), color, and texture. The study shows that little attention is given to the mechanical properties and texture of freeze-dried materials obtained from different conditions of the lyophilization process.
Overconfidence and Timing of Entry
Authors: Santos-Pinto Luis , Pires Tiago
Published: October 2020

We analyze the impact of overconfidence on the timing of entry in markets, profits, and welfare using an extension of the quantity commitment game. Players have private information about costs, one player is overconfident, and the other one rational. We find that for slight levels of overconfidence and intermediate cost asymmetries, there is a unique cost-dependent equilibrium where the overconfident player has a higher ex-ante probability of being the Stackelberg leader. Overconfidence lowers the profit of the rational player but can increase that of the overconfident player. Consumer rents increase with overconfidence while producer rents decrease which leads to an ambiguous welfare effect.
Landscape Genomics of a Widely Distributed Snake, Dolichophis caspius (Gmelin, 1789) across Eastern Europe and Western Asia
Authors: Mahtani-Williams Sarita , Fulton William , Desvars-Larrive Amelie , Lado Sara , Elbers Jean Pierre , Halpern Bálint , Herczeg Dávid , Babocsay Gergely , Lauš Boris , Nagy Zoltán Tamás , Jablonski Daniel , Kukushkin Oleg , Orozco-terWengel Pablo , Vörös Judit , Burger Pamela Anna
Published: October 2020

Across the distribution of the Caspian whipsnake (Dolichophis caspius), populations have become increasingly disconnected due to habitat alteration. To understand population dynamics and this widespread but locally endangered snake’s adaptive potential, we investigated population structure, admixture, and effective migration patterns. We took a landscape-genomic approach to identify selected genotypes associated with environmental variables relevant to D. caspius. With double-digest restriction-site associated DNA (ddRAD) sequencing of 53 samples resulting in 17,518 single nucleotide polymorphisms (SNPs), we identified 8 clusters within D. caspius reflecting complex evolutionary patterns of the species. Estimated Effective Migration Surfaces (EEMS) revealed higher-than-average gene flow in most of the Balkan Peninsula and lower-than-average gene flow along the middle section of the Danube River. Landscape genomic analysis identified 751 selected genotypes correlated with 7 climatic variables. Isothermality correlated with the highest number of selected genotypes (478) located in 41 genes, followed by annual range (127) and annual mean temperature (87). We conclude that environmental variables, especially the day-to-night temperature oscillation in comparison to the summer-to-winter oscillation, may have an important role in the distribution and adaptation of D. caspius.
Fine-Tuning of Alanyl-tRNA Synthetase Quality Control Alleviates Global Dysregulation of the Proteome
Authors: Kelly Paul , Kavoor Arundhati , Ibba Michael
Published: October 2020

One integral step in the transition from a nucleic acid encoded-genome to functional proteins is the aminoacylation of tRNA molecules. To perform this activity, aminoacyl-tRNA synthetases (aaRSs) activate free amino acids in the cell forming an aminoacyl-adenylate before transferring the amino acid on to its cognate tRNA. These newly formed aminoacyl-tRNA (aa-tRNA) can then be used by the ribosome during mRNA decoding. In Escherichia coli, there are twenty aaRSs encoded in the genome, each of which corresponds to one of the twenty proteinogenic amino acids used in translation. Given the shared chemicophysical properties of many amino acids, aaRSs have evolved mechanisms to prevent erroneous aa-tRNA formation with non-cognate amino acid substrates. Of particular interest is the post-transfer proofreading activity of alanyl-tRNA synthetase (AlaRS) which prevents the accumulation of Ser-tRNAAla and Gly-tRNAAla in the cell. We have previously shown that defects in AlaRS proofreading of Ser-tRNAAla lead to global dysregulation of the E. coli proteome, subsequently causing defects in growth, motility, and antibiotic sensitivity. Here we report second-site AlaRS suppressor mutations that alleviate the aforementioned phenotypes, revealing previously uncharacterized residues within the AlaRS proofreading domain that function in quality control.
Patient Safety Culture in EU Legislation
Authors: Pilarska Anna , Zimmermann Agnieszka , Piątkowska Kamila , Jabłoński Tomasz
Published: October 2020

Patient safety means a condition in which a patient does not suffer any unnecessary actual harm, nor is exposed to any potential harm related to healthcare. The World Health Organization’s recognition of patient safety, as one of the most important factors in determining high quality healthcare, initiated the systematic introduction of changes in the approach to this issue, both globally and on the level of individual healthcare service providers. In order to enhance the quality and ensure the safety of healthcare services provided, national, European Union, and worldwide institutions focus on the introduction of a so-called patient safety culture. The creation of this safety culture would not be possible without the establishment of its legal framework. The purpose of this article is to shed light on the legislative achievements of the European Union within patient safety, taking into consideration acts that summarize the level of implementation of individual recommendations. This study can be useful both for those who focus their scientific interests on the subject of patient safety and those who need concise information on the legislative measures of the Community in this respect, as well as for medical personnel who want to become acquainted with this issue without reading comprehensive legal acts.
Tourism under the Early Phase of COVID-19 in Four APEC Economies: An Estimation with Special Focus on SARS Experiences
Authors: Tran Bao-Linh , Chen Chi-Chung , Tseng Wei-Chun , Liao Shu-Yi
Published: October 2020

This study examines how experience of severe acute respiratory syndrome (SARS) influences the impact of coronavirus disease (COVID-19) on international tourism demand for four Asia-Pacific Economic Cooperation (APEC) economies, Taiwan, Hong Kong, Thailand, and New Zealand, over the 1 January–30 April 2020 period. To proceed, panel regression models are first applied with a time-lag effect to estimate the general effects of COVID-19 on daily tourist arrivals. In turn, the data set is decomposed into two nation groups and fixed effects models are employed for addressing the comparison of the pandemic-tourism relationship between economies with and without experiences of the SARS epidemic. Specifically, Taiwan and Hong Kong are grouped as economies with SARS experiences, while Thailand and New Zealand are grouped as countries without experiences of SARS. The estimation result indicates that the number of confirmed COVID-19 cases has a significant negative impact on tourism demand, in which a 1% COVID-19 case increase causes a 0.075% decline in tourist arrivals, which is a decline of approximately 110 arrivals for every additional person infected by the coronavirus. The negative impact of COVID-19 on tourist arrivals for Thailand and New Zealand is found much stronger than for Taiwan and Hong Kong. In particular, the number of tourist arrivals to Taiwan and Hong Kong decreased by 0.034% in response to a 1% increase in COVID-19 confirmed cases, while in Thailand and New Zealand, a 1% national confirmed cases increase caused a 0.103% reduction in tourism demand. Moreover, the effect of the number of domestic cases on international tourism is found lower than the effect caused by global COVID-19 mortality for the economies with SARS experiences. In contrast, tourist arrivals are majorly affected by the number of confirmed COVID-19 cases in Thailand and New Zealand. Finally, travel restriction in all cases is found to be the most influencing factor for the number of tourist arrivals. Besides contributing to the existing literature focusing on the knowledge regarding the nexus between tourism and COVID-19, the paper’s findings also highlight the importance of risk perception and the need of transmission prevention and control of the epidemic for the tourism sector.
Preventing Occupational Tuberculosis in Health Workers: An Analysis of State Responsibilities and Worker Rights in Mozambique
Authors: Garcia Regiane , Spiegel Jerry M. , Yassi Annalee , Ehrlich Rodney , Romão Paulo , Nunes Elizabete A. , Zungu Muzimkhulu , Mabhele Simphiwe
Published: October 2020

Given the very high incidence of tuberculosis (TB) among health workers in Mozambique, a low-income country in Southern Africa, implementation of measures to protect health workers from occupational TB remains a major challenge. This study explores how Mozambique’s legal framework and health system governance facilitate—or hinder—implementation of protective measures in its public (state-provided) healthcare sector. Using a mixed-methods approach, we examined international, constitutional, regulatory, and policy frameworks. We also recorded and analysed the content of a workshop and policy discussion group on the topic to elicit the perspectives of health workers and of officials responsible for implementing workplace TB policies. We found that despite a well-developed legal framework and national infection prevention and control policy, a number of implementation barrier persisted: lack of legal codification of TB as an occupational disease; absence of regulations assigning specific responsibilities to employers; failure to deal with privacy and stigma fears among health workers; and limited awareness among health workers of their legal rights, including that of collective action. While all these elements require attention to protect health workers from occupational TB, a stronger emphasis on their human and labour rights is needed alongside their perceived responsibilities as caregivers.
Copper Toxicity Links to Pathogenesis of Alzheimer’s Disease and Therapeutics Approaches
Authors: Ejaz Hafza Wajeeha , Wang Wei , Lang Minglin
Published: October 2020

Alzheimer’s disease (AD) is an irreversible, age-related progressive neurological disorder, and the most common type of dementia in aged people. Neuropathological lesions of AD are neurofibrillary tangles (NFTs), and senile plaques comprise the accumulated amyloid-beta (Aβ), loaded with metal ions including Cu, Fe, or Zn. Some reports have identified metal dyshomeostasis as a neurotoxic factor of AD, among which Cu ions seem to be a central cationic metal in the formation of plaque and soluble oligomers, and have an essential role in the AD pathology. Cu-Aβ complex catalyzes the generation of reactive oxygen species (ROS) and results in oxidative damage. Several studies have indicated that oxidative stress plays a crucial role in the pathogenesis of AD. The connection of copper levels in AD is still ambiguous, as some researches indicate a Cu deficiency, while others show its higher content in AD, and therefore there is a need to increase and decrease its levels in animal models, respectively, to study which one is the cause. For more than twenty years, many in vitro studies have been devoted to identifying metals’ roles in Aβ accumulation, oxidative damage, and neurotoxicity. Towards the end, a short review of the modern therapeutic approach in chelation therapy, with the main focus on Cu ions, is discussed. Despite the lack of strong proofs of clinical advantage so far, the conjecture that using a therapeutic metal chelator is an effective strategy for AD remains popular. However, some recent reports of genetic-regulating copper transporters in AD models have shed light on treating this refractory disease. This review aims to succinctly present a better understanding of Cu ions’ current status in several AD features, and some conflicting reports are present herein.
Specificity Studies of the Venezuelan Equine Encephalitis Virus Non-Structural Protein 2 Protease Using Recombinant Fluorescent Substrates
Authors: Bozóki Beáta , Mótyán János András , Hoffka Gyula , Waugh David S. , Tőzsér József
Published: October 2020

The non-structural protein 2 (nsP2) of alphavirus Venezuelan equine encephalitis virus (VEEV) is a cysteine protease that is responsible for processing of the viral non-structural polyprotein and is an important drug target owing to the clinical relevance of VEEV. In this study we designed two recombinant VEEV nsP2 constructs to study the effects of an N-terminal extension on the protease activity and to investigate the specificity of the elongated enzyme in vitro. The N-terminal extension was found to have no substantial effect on the protease activity. The amino acid preferences of the VEEV nsP2 protease were investigated on substrates representing wild-type and P5, P4, P2, P1, P1′, and P2′ variants of Semliki forest virus nsP1/nsP2 cleavage site, using a His6-MBP-mEYFP recombinant substrate-based protease assay which has been adapted for a 96-well plate-based format. The structural basis of enzyme specificity was also investigated in silico by analyzing a modeled structure of VEEV nsP2 complexed with oligopeptide substrate. To our knowledge, in vitro screening of P1′ amino acid preferences of VEEV nsP2 protease remains undetermined to date, thus, our results may provide valuable information for studies and inhibitor design of different alphaviruses or other Group IV viruses.
The Physiological and Pathological Roles of Mitochondrial Calcium Uptake in Heart
Authors: Lai Lo , Qiu Hongyu
Published: October 2020

Calcium ion (Ca2+) plays a critical role in the cardiac mitochondria function. Ca2+ entering the mitochondria is necessary for ATP production and the contractile activity of cardiomyocytes. However, excessive Ca2+ in the mitochondria results in mitochondrial dysfunction and cell death. Mitochondria maintain Ca2+ homeostasis in normal cardiomyocytes through a comprehensive regulatory mechanism by controlling the uptake and release of Ca2+ in response to the cellular demand. Understanding the mechanism of modulating mitochondrial Ca2+ homeostasis in the cardiomyocyte could bring new insights into the pathogenesis of cardiac disease and help developing the strategy to prevent the heart from damage at an early stage. In this review, we summarized the latest findings in the studies on the cardiac mitochondrial Ca2+ homeostasis, focusing on the regulation of mitochondrial calcium uptake, which acts as a double-edged sword in the cardiac function. Specifically, we discussed the dual roles of mitochondrial Ca2+ in mitochondrial activity and the impact on cardiac function, the molecular basis and regulatory mechanisms, and the potential future research interest.
Patient-Reported Reasons for Not Using Primary Prevention Statin Therapy
Authors: DeWitt Cassandra M. , Ponce Robert B. , Bry Hayley , Wali Soma , Sedlander Erica , Ladapo Joseph A.
Published: October 2020

Almost half of patients who meet American College of Cardiology/American Heart Association (ACC/AHA) criteria for statin therapy are untreated. We aimed to evaluate patient-reported reasons for not using guideline-recommended statin therapy in a public healthcare system. Achieving this goal is key to addressing gaps in care and reducing preventable cardiovascular morbidity. We surveyed patients who met 2013 ACC/AHA guidelines for statin therapy but were not using statins. The survey probed domains of patient knowledge regarding cardiovascular health and benefits of statins, barriers to use, physician trust, and interest in cardiovascular care. Among 71 patients eligible for guideline-recommended statin therapy but not currently taking statins, 49 (69%) had a high school education or lower, 41 (58%) reported that they were unaware they should be prescribed a statin and 49 (69%) were unaware of the benefits of statins. Almost all patients, 70 (99%), reported caring about their cardiovascular health, 61 (86%) reported that they had a high level of trust in their physician, and 51 (72%) reported a willingness to follow their physician’s advice. Despite interest in cardiovascular health, awareness of benefits of statin therapy was low and knowledge of recommended statin therapy was low. Increasing patients’ awareness of their eligibility through systematic testing and linkage to statin therapy, along with education, may increase statin use among patients recommended for therapy.
Incidence of Differentiation Syndrome Associated with Treatment Regimens in Acute Myeloid Leukemia: A Systematic Review of the Literature
Authors: Gasparovic Lucia , Weiler Stefan , Higi Lukas , Burden Andrea M.
Published: October 2020

Differentiation syndrome (DS) is a potentially fatal adverse drug reaction caused by the so-called differentiating agents such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), used for remission induction in the treatment of the M3 subtype of acute myeloid leukemia (AML), acute promyelocytic leukemia (APL). However, recent DS reports in trials of isocitrate dehydrogenase (IDH)-inhibitor drugs in patients with IDH-mutated AML have raised concerns. Given the limited knowledge of the incidence of DS with differentiating agents, we conducted a systematic literature review of clinical trials with reports of DS to provide a comprehensive overview of the medications associated with DS. In particular, we focused on the incidence of DS reported among the IDH-inhibitors, compared to existing ATRA and ATO therapies. We identified 44 published articles, encompassing 39 clinical trials, including 6949 patients. Overall, the cumulative incidence of DS across all treatment regimens was 17.7%. Incidence of DS was notably lower in trials with IDH-inhibitors (10.4%) compared to other regimens, including ATRA and/or ATO (15.4–20.6%). Compared to other therapies, the median time to onset was four times longer with IDH-inhibitors (48 vs. 11 days). Treating oncologists should be mindful of this potentially fatal adverse drug reaction, as we expect the current trials represent an underestimation of the actual incidence.
Psychological Functioning of Patients Undergoing Oral Surgery Procedures during the Regime Related with SARS-CoV-2 Pandemic
Authors: Pylińska-Dąbrowska Dorota , Starzyńska Anna , Cubała Wiesław Jerzy , Ragin Karolina , Alterio Daniela , Jereczek-Fossa Barbara Alicja
Published: October 2020

The coronavirus pandemic has become a huge global challenge medically, economically and psychologically. The COVID-19 pandemic shows that the population can experience general psychological distress. The sanitary regime in dental offices and lack of vaccine for coronavirus may have an impact on the level of dental anxiety among patients undergoing oral surgery procedures. A clinical study was conducted between November 2019 and September 2020. A total of 175 patients (n = 175) were enrolled in the research. The aim of the study was to assess the attitude of patients towards the new situation related to the reduced availability of dental offices providing oral surgery procedures. The level of anxiety associated with surgical intervention was measured using a self-made COVID-19 questionnaire and the MDAS scale. The ED-5Q questionnaire and EQ-VAS scale were also used in this research. The study showed that 21.9% of respondents presented with increased anxiety about a dental visit compared with the time before the pandemic. This epidemiological situation has led to an overwhelming increase in moderate dental anxiety (M: 11.4) among patients undergoing oral surgery procedures. The quality of patients’ health (EQ-VAS) related to the impact of the coronavirus pandemic and the quarantine decreased by 10 percentage points. Oral surgeons should be prepared for more anxious patients in dental offices during the pandemic.
Preschool Asthma Symptoms in Children Born Preterm: The Relevance of Lung Function in Infancy
Authors: Sanchez-Solis Manuel , Parra-Carrillo Maria Soledad , Mondejar-Lopez Pedro , Garcia-Marcos Patricia W , Garcia-Marcos Luis
Published: October 2020

Background: The aim of the study is to assess whether lung function of infants born preterm predicts wheezing in pre-school age. Methods: A survey of the core wheezing questionnaire of the International Study on Asthma and Allergy in Children was administered to parents of preterm newborns, to whom lung function tests were performed at a corrected age of six months, and who, at the time of the survey, were between three and nine years of age. Results: Low values of all lung function parameters measured, except FVC, were predictors of wheezing at some time in life, (FEV0.5 OR: 0.62 (95%CI 0.39; 0.995); FEV0.5/FVC OR: 0.73 (0.54; 0.99)) FEF75 OR: 0.60 [0.37; 0.93]; FEF25-75 OR: 0.57 (0.37; 0.89)); and of wheezing in the past year (FEV0.5 OR: 0.36 (0.17; 0.76); FEV0.5/FVC OR: 0.59 (0.38; 0.93); FEF75 OR: 0.38 [0.19; 0.76]; FEF25-75 OR: 0.35 (0.17; 0.70). In addition, FEV0.5/FVC values lower than the lowest limit of normality, were predictive of hospital admissions due to wheezing (OR: 3.07; (1.02; 9.25)). Conclusions: Limited lung function in infancy is predictive of both future wheezing and hospitalization for a wheezing episode.
Hypertensive Cardiotoxicity in Cancer Treatment—Systematic Analysis of Adjunct, Conventional Chemotherapy, and Novel Therapies—Epidemiology, Incidence, and Pathophysiology
Authors: Chung Robin , Tyebally Sara , Chen Daniel , Kapil Vikas , Walker J. Malcolm , Addison Daniel , Ismail-Khan Roohi , Guha Avirup , Ghosh Arjun K
Published: October 2020

Cardiotoxicity is the umbrella term for cardiovascular side effects of cancer therapies. The most widely recognized phenotype is left ventricular dysfunction, but cardiotoxicity can manifest as arrhythmogenic, vascular, myocarditic and hypertensive toxicities. Hypertension has long been regarded as one of the most prevalent and modifiable cardiovascular risk factors in the general population, but its relevance during the cancer treatment journey may be underestimated. Hypertensive cardiotoxicity occurs de novo in a substantial proportion of treated cancer patients. The pathology is incompletely characterized—natriuresis and renin angiotensin system interactions play a role particularly in conventional treatments, but in novel therapies endothelial dysfunction and the interaction between the cancer and cardiac kinome are implicated. There exists a treatment paradox in that a significant hypertensive response not only mandates anti-hypertensive treatment, but in fact, in certain cancer treatment scenarios, hypertension is a predictor of cancer treatment efficacy and response. In this comprehensive review of over 80,000 patients, we explored the epidemiology, incidence, and mechanistic pathophysiology of hypertensive cardiotoxicity in adjunct, conventional chemotherapy, and novel cancer treatments. Conventional chemotherapy, adjunct treatments, and novel targeted therapies collectively caused new onset hypertension in 33–68% of treated patients. The incidence of hypertensive cardiotoxicity across twenty common novel therapies for any grade hypertension ranged from 4% (imatinib) to 68% (lenvatinib), and high grade 3 or 4 hypertension in <1% (imatinib) to 42% (lenvatinib). The weighted average effect was all-grade hypertension in 24% and grade 3 or 4 hypertension in 8%.
Effectiveness of a Multicomponent Treatment for Fibromyalgia Based on Pain Neuroscience Education, Exercise Therapy, Psychological Support, and Nature Exposure (NAT-FM): A Pragmatic Randomized Controlled Trial
Authors: Serrat Mayte , Almirall Míriam , Musté Marta , Sanabria-Mazo Juan P. , Feliu-Soler Albert , Méndez-Ulrich Jorge L. , Luciano Juan V. , Sanz Antoni
Published: October 2020

A recent study (FIBROWALK) has supported the effectiveness of a multicomponent treatment based on pain neuroscience education (PNE), exercise therapy (TE), cognitive behavioral therapy (CBT), and mindfulness in patients with fibromyalgia. The aim of the present RCT was: (a) to analyze the effectiveness of a 12-week multicomponent treatment (nature activity therapy for fibromyalgia, NAT-FM) based on the same therapeutic components described above plus nature exposure to maximize improvements in functional impairment (primary outcome), as well as pain, fatigue, anxiety-depression, physical functioning, positive and negative affect, self-esteem, and perceived stress (secondary outcomes), and kinesiophobia, pain catastrophizing thoughts, personal perceived competence, and cognitive emotion regulation (process variables) compared with treatment as usual (TAU); (b) to preliminarily assess the effects of the nature-based activities included (yoga, Nordic walking, nature photography, and Shinrin Yoku); and (c) to examine whether the positive effects of TAU + NAT-FM on primary and secondary outcomes at post-treatment were mediated through baseline to six-week changes in process variables. A total of 169 FM patients were randomized into two study arms: TAU + NAT-FM vs. TAU alone. Data were collected at baseline, at six-week of treatment, at post-treatment, and throughout treatment by ecological momentary assessment (EMA). Using an intention to treat (ITT) approach, linear mixed-effects models and mediational models through path analyses were computed. Overall, TAU + NAT-FM was significantly more effective than TAU at posttreatment for the primary and secondary outcomes evaluated, as well as for the process variables. Moderate-to-large effect sizes were achieved at six-weeks for functional impairment, anxiety, kinesiophobia, perceived competence, and positive reappraisal. The number needed to treat (NNT) was 3 (95%CI = 1.6–3.2). The nature activities yielded an improvement in affective valence, arousal, dominance, fatigue, pain, stress, and self-efficacy. Kinesiophobia and perceived competence were the mediators that could explain a significant part of the improvements obtained with TAU + NAT-FM treatment. TAU + NAT-FM is an effective co-adjuvant multicomponent treatment for improving FM-related symptoms.
Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI
Authors: Park Mina , Kim Jin Woo , Ahn Sung Jun , Cha Yoon Jin , Suh Sang Hyun
Published: October 2020

Objectives: Aging is a major risk factor for many neurological disorders and is associated with dural lymphatic dysfunction. We sought to evaluate the association of aging with the volume of the peri-sinus lymphatic space using contrast-enhanced 3T T1-weighted black-blood magnetic resonance imaging (MRI). Methods: In this retrospective study, 165 presumed neurologically normal subjects underwent brain MRIs for cancer staging between April and November 2018. The parasagittal peri-sinus lymphatic space was evaluated using contrast-enhanced 3D T1-weighted black-blood MRIs, and volumes were measured with semiautomatic method. We compared the volumes of normalized peri-sinus lymphatic spaces between the elderly (≥65 years, n = 72) and non-elderly (n = 93) groups and performed multivariate logistic regression analyses to assess if aging is independently associated with the volume of normalized peri-sinus lymphatic spaces. Results: The normalized peri-sinus lymphatic space volume was significantly higher in the elderly than in the non-elderly (mean, 3323 ± 758.7 mL vs. 2968.7 ± 764.3 mL, p = 0.047). After adjusting the intracranial volume, age age was the strongest factor independently associated with peri-sinus lymphatic space volume (β coefficient, 28.4 (5.7–51.2), p = 0.015) followed by male sex (β coefficient, 672.4 (113.5–1230.8), p = 0.019). Conclusions: We found that the peri-sinus dural lymphatic space volume was higher in the elderly group than in the non-elderly group, and the increased peri-sinus lymphatic space was independently associated with aging. These findings indicate that the peri-sinus lymphatic space may be related with the aging process and lymphatic system dysfunction as well.
Investment Analysis of Waste Heat Recovery System Installations on Ships’ Engines
Authors: Olaniyi Eunice O. , Prause Gunnar
Published: October 2020

This study considers incentive provisions for investment decisions related to waste heat recovery system (WHRS) installations on ships to reduce CO2 emissions and improve ships’ engine efficiency. The economic assessment of WHRS installations in the shipping sector is not widely covered in the literature. A reason for this might be that the conventional financial evaluation of sensitive choices is commonly done through capital budgeting methods, which are not flexible enough to integrate future changes in fuel prices and long-term aspects of other costs. Thus, this work evaluates the WHRS investment using the classical budgeting instruments as well as the real-options approach (a more sophisticated approach) to accommodate the presumed expected future changes in the volatile maritime markets. Following the methodology of triangulation, three case studies of ships with varying operational conditions empirically validate the result to depict the practical use of the real-options evaluation method in investment assessment. The capital budgeting analysis reveals that the investment in maritime WHRS technology is only economically favorable under certain frame conditions projected in the work that shows a more realistic assessment of the project.
Immunological Aspects of Chytridiomycosis
Authors: Grogan Laura F. , Humphries Josephine E. , Robert Jacques , Lanctôt Chantal M. , Nock Catherine J. , Newell David A. , McCallum Hamish I.
Published: October 2020

Amphibians are currently the most threatened vertebrate class, with the disease chytridiomycosis being a major contributor to their global declines. Chytridiomycosis is a frequently fatal skin disease caused by the fungal pathogens Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal). The severity and extent of the impact of the infection caused by these pathogens across modern Amphibia are unprecedented in the history of vertebrate infectious diseases. The immune system of amphibians is thought to be largely similar to that of other jawed vertebrates, such as mammals. However, amphibian hosts are both ectothermic and water-dependent, which are characteristics favouring fungal proliferation. Although amphibians possess robust constitutive host defences, Bd/Bsal replicate within host cells once these defences have been breached. Intracellular fungal localisation may contribute to evasion of the induced innate immune response. Increasing evidence suggests that once the innate defences are surpassed, fungal virulence factors suppress the targeted adaptive immune responses whilst promoting an ineffectual inflammatory cascade, resulting in immunopathology and systemic metabolic disruption. Thus, although infections are contained within the integument, crucial homeostatic processes become compromised, leading to mortality. In this paper, we present an integrated synthesis of amphibian post-metamorphic immunological responses and the corresponding outcomes of infection with Bd, focusing on recent developments within the field and highlighting future directions.
The Potential Use of Drones for Tourism in Crises: A Facility Location Analysis Perspective
Authors: Ilkhanizadeh Shiva , Golabi Mahmoud , Hesami Siamand , Rjoub Husam
Published: October 2020

Considering the recent lockdowns and travel bans due to COVID-19, novel tourism strategies are necessary to face the increasing need for innovative products and services and to ensure long-term sustainable growth. This study looks into the potential use of drones in providing online virtual tours of open-space tourist attractions. To do so, a novel mixed-integer linear mathematical model is developed to optimally determine the number and location of required facilities and the number of drones assigned to each center. The model is applied to a case study of Rome by selecting six historic sites as the tourist attractions and considering several candidate locations for establishing the facilities. The results of different potential scenarios imply that the project is profitable, even if the demand for virtual tours is low.
A Review of Functional Separators for Lithium Metal Battery Applications
Authors: Jang Jooyoung , Oh Jiwoong , Jeong Hyebin , Kang Woosuk , Jo Changshin
Published: October 2020

Lithium metal batteries are considered “rough diamonds” in electrochemical energy storage systems. Li-metal anodes have the versatile advantages of high theoretical capacity, low density, and low reaction potential, making them feasible candidates for next-generation battery applications. However, unsolved problems, such as dendritic growths, high reactivity of Li-metal, low Coulombic efficiency, and safety hazards, still exist and hamper the improvement of cell performance and reliability. The use of functional separators is one of the technologies that can contribute to solving these problems. Recently, functional separators have been actively studied and developed. In this paper, we summarize trends in the research on separators and predict future prospects.
A Light-Weight Deep-Learning Model with Multi-Scale Features for Steel Surface Defect Classification
Authors: Liu Yang , Yuan Yachao , Balta Cristhian , Liu Jing
Published: October 2020

Automatic inspection of surface defects is crucial in industries for real-time applications. Nowadays, computer vision-based approaches have been successfully employed. However, most of the existing works need a large number of training samples to achieve satisfactory classification results, while collecting massive training datasets is labor-intensive and financially costly. Moreover, most of them obtain high accuracy at the expense of high latency, and are thus not suitable for real-time applications. In this work, a novel Concurrent Convolutional Neural Network (ConCNN) with different image scales is proposed, which is light-weighted and easy to deploy for real-time defect classification applications. To evaluate the performance of ConCNN, the NEU-CLS dataset is used in our experiments. Simulation results demonstrate that ConCNN performs better than other state-of-the-art approaches considering accuracy and latency for steel surface defect classification. Specifically, ConCNN achieves as high as 98.89% classification accuracy with only around 5.58 ms latency over low training cost.
Effect of the Combination of Superabsorbent Polymers for Autogenous Shrinkage Control with Steel Fibers of High-Performance Concrete under Uniaxial Tension Using DIC
Authors: Santos Karyne Ferreira dos , Ribeiro António Carlos Bettencourt Simões , Silva Eugênia Fonseca da , Manzano Manuel Alejandro Rojas , Motta Leila Aparecida de Castro , Toledo Filho Romildo Dias
Published: October 2020

This paper presents a study of the effect of a superabsorbent polymer (SAP) for autogenous shrinkage control on the uniaxial tensile behavior of steel fiber reinforced concrete (SFRC). The use of fibers and SAP potentially increases the durability of the concrete, preventing cracking by autogenous shrinkage and enhancing post-cracking behavior. Furthermore, SAP can provide further hydration for self-healing purposes and improve the ductility of the SFRC. In order to evaluate the effect of the addition of SAP in SFRC, dog-bone SFRC specimens with different dosages of superabsorbent polymers were cast and tested under uniaxial tension. The digital image correlation (DIC) technique was used to understand the effect of SAP on the steel fibers’ crack-bridging mechanisms. Surface strains and crack openings were inferred using the DIC technique. The effect of SAP and fibers on fresh and hardened concrete was individually investigated by flow tests and compressive strength tests. Autogenous shrinkage was measured in plain concrete to investigate the minimum SAP content required to mitigate autogenous shrinkage of 0.3%. The use of 0.3% SAP was also sufficient to reach multiple cracking behavior. This content of SAP completely suppressed the autogenous shrinkage with minimal side effects on compressive strength. An analytical formulation for the tensile behavior of SFRC was developed using the variable engagement model, presenting a mean correlation of R2 of 0.97 with the experimental results.
Evaluation of Ti–Mn Alloys for Additive Manufacturing Using High-Throughput Experimental Assays and Gaussian Process Regression
Authors: Gong Xinyi , Yabansu Yuksel , Collins Peter , Kalidindi Surya
Published: October 2020

Compositionally graded cylinders of Ti–Mn alloys were produced using the Laser Engineered Net Shaping (LENS™) technique, with Mn content varying from 0 to 12 wt.% along the cylinder axis. The cylinders were subjected to different post-build heat treatments to produce a large sample library of α–β microstructures. The microstructures in the sample library were studied using back-scattered electron (BSE) imaging in a scanning electron microscope (SEM), and their mechanical properties were evaluated using spherical indentation stress–strain protocols. These protocols revealed that the microstructures exhibited features with averaged chord lengths in the range of 0.17–1.78 μm, and beta content in the range of 20–83 vol.%. The estimated values of the Young’s moduli and tensile yield strengths from spherical indentation were found to vary in the ranges of 97–130 GPa and 828–1864 MPa, respectively. The combined use of the LENS technique along with the spherical indentation protocols was found to facilitate the rapid exploration of material and process spaces. Analyses of the correlations between the process conditions, several key microstructural features, and the measured material properties were performed via Gaussian process regression (GPR). These data-driven statistical models provided valuable insights into the underlying correlations between these variables.
An Empowerment Scale Analysis of Mexican MSMEs: Modeling with Covariance Structures
Authors: del Río-Rama María de la Cruz , Ríos-Manríquez Martha , Álvarez-García José , Sánchez-Fernández María Dolores
Published: October 2020

Trained human capital is a source of incalculable resources, with an impact on the results of companies. For this reason, companies must carefully consider three aspects: empowerment with the consideration of the cognitive state of their collaborators; training and compensation; and fluidity in information sharing. Although granting empowerment to collaborators has been shown to be beneficial for organizations, its adoption has not been popularized. Therefore, it remains a construct that needs to be studied and understood, considering that it is influenced by the organizational culture of companies. In this research, the main objective was to examine the factor structure of the empowerment scale from the perspective of the owner or manager of the micro, small and medium-sized companies of Guanajuato, Mexico; using the dimensions of psychological empowerment; fluidity in information sharing; as well as training and compensation. The methodology is based on the Mathematical Economy; application of mathematical methods to represent theories and analyze problems in economics. This investigation used an exploratory and confirmatory factor analysis (CFA) to validate the proposed measurement scale. The sample is made up of 222 valid questionnaires. The CFA provided evidence that the model that best fits the data is a second-order model made up of two dimensions: self-efficacy and influence on the company’s results, which carry the psychological empowerment construct. These results make clear that although information is necessary to train human capital, cognitive variables are more important in the empowerment of human capital.
Stochastic Aspects of Proportional Vitalities Model
Authors: Shrahili Mansour , Albabtain Abdulhakim A. , Kayid Mohamed , Kaabi Zahra
Published: October 2020

In this paper, a family of models requiring proportional mean life vitalities is considered. The problem of estimation of the parameter(s) of the model is studied in two cases of known and unknown baselines along with some simulation studies to detect the adequacy of fitting. Closure and preservation properties of some ageing classes and stochastic orders are derived.