bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of depression in the Brazilian private healthcare system: patient journey and economic burden study associating claim database and expert’s opinion approach
Authors: Matos Marco Antonio , Ogata Alberto , Abdo Carmita , Gondo Celso , Lodi Maria Teresa , Stefani Stephen , Bilevicius Elizabeth
Published: June 2023

Objective: The study aimed to describe the profile and economic burden of patients with depression from the perspective of the Brazilian Private Healthcare System (PHS). Methods: A two-step methodological quantitative-qualitative research design was performed: retrospective descriptive analysis of the Orizon database of patients with at least one claim of depression (F33, F38, or F39) in PHS (2013-2019) and experienced physicians perspective from an expert meeting. Results: 1,802 patients fulfilling the eligibility criteria counted BRL 74,978 million across the 4-year period. Over this period, nearly 60% of patients had a medical appointment (6.6 appointments per patient, on average), 61% had a psychologist, 9.8% had a psychiatrist appointment, and an average of 115.2 exams and 8.7 emergency visits per patient were performed. According to the experts, the economic impact of depression is more significant when considering the indirect costs related to productivity loss and impairment in occupational and interpersonal functioning. Conclusion: Identifying and diagnosing patients with depression and their real burden is challenging; even with significant costs identified in the claim database analyses in the Brazilian PHS, the real impact must be higher if indirect costs are considered. The depressive disorder should be prioritized in the Brazilian PHS to establish more adequate health policies.
Gravidade da depressão, resposta ao tratamento e PRO (incapacidade e QoL) em pacientes com DRT em um ano de acompanhamento com tratamento padrão: análise do subgrupo brasileiro do estudo observacional multinacional TRAL
Authors: Caldieraro Marco Antonio , Teng Chei Tung , Lacerda Acioly L. T. , Quarantini Lucas C. , Grabowsiky Hamilton , Kanevsky Gabriela , Perocco Sergio
Published: June 2023

Objetivo: A depressão resistente ao tratamento (DRT) é uma preocupação primária no Brasil devido à sua natureza onerosa e complexa, enquanto o diagnóstico e o tratamento geralmente são desafiadores. O presente manuscrito apresenta os resultados clínicos de um ano de acompanhamento em pacientes com DRT em tratamento padrão (SOC) no subgrupo brasileiro do estudo de Depressão Resistente ao Tratamento na América Latina (TRAL). Métodos: Essa fase longitudinal do estudo TRAL tinha como meta caracterizar alterações nos resultados clínicos e outras variáveis de interesse (p. ex., qualidade de vida, incapacidade) em um ano de acompanhamento em pacientes com DRT em 10 centros no Brasil. Os pacientes incluídos tinham diagnóstico clínico de DRT com base nos critérios DSM-5 e confirmado por MINI. A Escala de Depressão de Montgomery-Asberg (MADRS) era usada para avaliar a gravidade da doença e os resultados clínicos. Outras escalas de depressão e instrumentos classificados pelo paciente eram usadas para medir resultados correlacionados. Resultados: Cento e cinquenta e oito pacientes com DRT, na maioria mulheres (84,4%) com idade média de 48,55 anos, foram incluídos na análise. Apenas 31,4% dos pacientes apresentaram uma resposta clinicamente significativa, 10,3% tiveram recidiva e 26,7% alcançaram remissão, conforme medido pela MADRS no final do estudo (EOS). Aproximadamente 55% dos pacientes apresentavam depressão grave/moderadamente grave no EOS. Problemas de mobilidade, cuidados pessoais, problemas nas atividades usuais e dor e desconforto foram relatados pela maioria dos pacientes no EOS, assim como comprometimento marcado/extremo das atividades no trabalho/escola e da vida social/das atividades de lazer no EOS. Conclusões: Os resultados clínicos alcançados atualmente ainda são notavelmente insatisfatórios para DRT. Portanto, o envolvimento de todas as partes interessadas é essencial para implementar protocolos de tratamento mais eficazes no Brasil.
Developing Persuasive Systems for Marketing: The interplay of persuasion techniques, customer traits and persuasive message design.
Authors: braca annye , Dondio Pierpaolo
Published: June 2023

This paper presents a comprehensive review of persuasion techniques and their applications in the context of designing persuasive communication systems for marketing purposes. The study provides a condensed taxonomy of techniques and offer examples to guide the development of effective persuasive messages. Furthermore, the paper explores how attitudes, personality traits, and emotions can be leveraged as input data in predictive models, including machine learning approaches. The study's findings offer valuable insights for the design and implementation of persuasive communication systems across diverse contexts, including marketing and advertising, public health campaigns, and political messaging. This paper has the potential to serve as a valuable resource for both researchers and practitioners seeking to enhance their understanding of the science of persuasion, as it synthesizes existing literature and provides practical examples. In this way, the paper contributes to the field of persuasion research and practice, serving as a valuable tool for those seeking to expedite and deepen their knowledge of persuasive communication.
Quality assessment of the Topo-Iberia CGPS stations and data quality's effects on postfit ionosphere-free phase residuals
Authors: García-Armenteros Juan Antonio
Published: June 2023

GPS data from the Topo-Iberia network spanning a period of almost 12 years (2008–2020) have been analyzed. The data quality information for all 26 Topo-Iberia stations is provided for the first time complementing the Spanish Geological Survey’s storage work. Data analyses based on quality indicators obtained using TEQC have been carried out. The guidelines and data quality information from the IGS stations have been considered as the quality references. The stations ALJI, EPCU, and TIOU stand out as the worst stations, and on the contrary FUEN, PALM, PILA, and TRIA meet the quality requirements to become an IGS station. The relationship between the GPS data quality and their GAMIT- and GipsyX-derived postfit ionosphere-free phase residuals has also been studied, and the results reveal an inversely proportional relationship. It has been found that the stations showing an increase in elevation of the horizon line, also show an increase in cycle slips and multipath, are among the poorest quality stations, and among those with the highest postfit RMS of phase residuals. Moreover, the evolution of the vegetation around the antenna should be considered as it could cause the progressive loss of quality, not complying with the IGS standards. The quality assessment carried out shows that the Topo-Iberia stations are appropriate for geodetic purposes, but a permanent monitoring would be necessary to avoid the least possible loss of data and quality. In addition, a method to characterize the GNSS data quality is proposed.
Behavioral deficits in rats exposed folate receptor alpha antibodies in utero are transmitted to the next generation
Authors: Quadros Edward , Amaro-Barron Jonathan , Bobrowski-Khoury Natasha
Published: June 2023

Folate deficiency can lead to a myriad of disruptions in neurodevelopment including neural tube defects, developmental anomalies, and functional deficits, such as autism spectrum disorder (ASD). Folate receptor alpha (FRα) is the primary transporter of folate from the mother to the fetus and into the brain. A major subset of the ASD patients and their family members have autoantibodies against FRα that can block folate transport. Therefore, we investigated the effect of exposure to folate receptor alpha antibodies during fetal development, on behavioral deficits in the offspring in a rat model and determined if their deficits are passed on to a subsequent generation; thus, contributing to inheritance of the behavioral phenotype. We have produced a rat folate receptor alpha specific antibody (FRαAb) that when injected intraperitoneally into a dam on gestation day (GD)8, produces a litter with behavioral deficits in social communication, social interaction, including learning, memory, and cognition. Using this model, we tested the litter directly exposed to FRαAb and bred the offspring that had an affected phenotype to produce a litter that was not directly exposed to FRαAb. We observed social communication deficits and deficits in learning performance in both generations which provides preliminary evidence to indicate transmission of a behavioral phenotype associated with the FRαAb exposure to the next generation. This work supports the growing evidence that an altered maternal immune and/or micronutrient environment has a generational effect on ASD offspring, likely transmitted by non-Mendelian inheritance.
Relationship between initial functional level and weight change in individuals with subacute spinal cord injuries. A retrospective observational study
Authors: Brinkmann Maj-Britt , Aadal Lena , Næss-Schmidt Erhard , Kjeldsen Simon , Skovbjerg Frederik
Published: June 2023

Study Design: Retrospective observational study
Objectives: 1) Describe weight change during and after in-hospital rehabilitation based on a large sample of retrospectively collected data. 2) Investigate associations between initial functional level and the change in weight, during and after in-hospital rehabilitation.
Setting: Spinal Cord Injury Center of Western Denmark
Methods: We extracted relevant information from a database of electronic hospital records in the period June 2013 to March 2023 on people admitted for in-hospital rehabilitation after their first time spinal cord injury. We used the routinely gathered information such as weight measurements and Spinal Cord Injury Independence Measure to assess weight change and the association to initial functional levels using multiple linear regression both during and after in-hospital rehabilitation.
Results: During in-hospital rehabilitation (n = 579) the mean weight change was estimated at -0.25 kg 95% CI, -1.06–0.56 (p = 0.548), while subgroups of BMI revealed diverse patterns. After rehabilitation (n = 365) mean weight change was estimated at 2.47 kg 95% CI, 0.65–4.28 (p = 0.008). SCIM selfcare was associated with weight gain during in-hospital rehabilitation, and weight loss after discharge.
Conclusions: On average individuals with SCI had stable weight during in-hospital rehabilitation. When stratified on BMI groups individuals with initial low BMI increase their weight, while individuals with initial high BMI decrease their weight during in-hospital rehabilitation. After in-hospital rehabilitation individuals on average increase their weight, regardless of their initial BMI. SCIM selfcare revealed an association between weight change both within and after in-hospital rehabilitation.
Generation Of Dense Urban Features Using Conditional GAN
Authors: Nihal Anurag , Kumar Vaibhav
Published: June 2023

This paper discusses the use of conditional Generative Adversarial Networks
(GANs) to generate dense urban features in satellite images and evaluate their
effectiveness in semantic segmentation tasks. High-resolution true-color satellite
imagery of Mumbai, obtained from Pleiades-1A at a 0.5m resolution, is utilized
for the study. The proposed Multiple Discriminator pix2pix (MD-pix2pix) model,
which employs multiple discriminators and a modified training procedure, is introduced
to generate realistic satellite images. The performance of the MD-pix2pix
model is compared to the traditional pix2pix model using a mix dataset of real and
generated satellite images. The synthesized satellite images are assessed for their
effectiveness in semantic segmentation tasks using various CNN models, including
VGG16-UNet, MobileNetV2-UNet, and DeepLabV3+. The study aims to overcome
the limitations of existing datasets that do not include informal settlements,
such as slum areas, which are common in many cities. The results indicate that
the MD-pix2pix model produces more realistic satellite images with greater variability
in vegetation type, slum arrangements, and built-ups than the traditional
pix2pix model. The synthetically generated satellite images are also effective in
semantic segmentation tasks, with better segmentation accuracy achieved using
the MD-pix2pix generated images for computationally less expensive architectures
such as MobileNetV2-UNet. This study highlights the potential of GANs
to generate realistic satellite images for urban feature mapping and monitoring
applications.
Color Doppler ultrasound for assessing the efficacy of conservative treatment of pediatric femoral shaft fractures at different sites
Authors: Li Xiang , Liu Xing , Wu Jun , Zhang Yuan , Shi Mingyan , Zhang Man , Wang Peikang , Zhang Xinkai
Published: June 2023

Background: Ultrasonography is a new alternative to conventional X-ray in fracture examination that avoids radiation damage, but it is unclear whether it can assess fracture healing in children. To clarify the value of ultrasound applications, in this study we used Color Doppler ultrasound to assess whether there were differences between the recovery of children with femoral shaft fractures at different sites in conservative treatment.
Methods: We performed a prospective cohort study to investigate children with femoral shaft fractures treated conservatively who were admitted to our hospital from March 2017 to December 2021. All cases were divided into three groups according to the site of the fracture: upper, middle, and lower segments, and the children were follow-up and observed using Color Doppler ultrasound at the 1st, 2nd, 3rd, and 4th weeks after the injury, compared the fracture recovery between the groups.
Results: This study included 31 males and 12 females, for a total of 43 children with femoral shaft fractures. The results showed no statistical difference in the ratio of callus thickness to femur width, callus growth rate, and vascular resistance index (RI) detected at different fracture sites at the same time after injury (p > 0.05). However, we found that the RI were smaller in the group with faster callus growth rate and vice versa. In addition, when examined at different time, there were statistical differences in the ratio of callus thickness to femur width, callus growth rate, and RI between the different time groups (p > 0.05), and as the time after injury increased, the callus growth rate gradually became slower and the RI value gradually decreased.
Conclusions: These results indicate that children with femoral shaft fractures at different sites have a consistent degree of recovery during conservative treatment, and Color Doppler ultrasound can monitor the recovery process and effectively evaluate bone callus growth by detecting the blood supply around the edge of the fracture.
Raking: an innovative and sustainable echinoculture method to produce “caviar” without sacrificing sea urchins
Authors: Rakaj Arnold , Grosso Luca , Fianchini Alessandra , Cataudella Stefano
Published: June 2023

Sea urchin aquaculture represents a promising tool to achieve sustainable aquaculture, promote sector diversification and obtain high-priced products using low-trophic species. However, although echinoculture has been practised for several decades, this sector has not yet achieved economic sustainability and large-scale development mainly due to problems linked to long-term sea urchin rearing cycles. In this paper we present a groundbreaking production method, called "Raking", for sea urchin caviar production that represents a technological advancement both in terms of production approach and in the final product. Raking, in fact, is a no-kill method for the harvesting of eggs as a final product (sea urchin caviar) from only-female batches of sea urchins, meaning that the same sea urchins are employed through several production cycles. This method, therefore, helps overcome important biological and economic constraints of echinoculture, such as high mortality in the early development stages and the slow speed of growth to reach viable market size. This new production method was compared with a traditional gonad enhancement method known as Bulking. Our results showed that multi-cycle production using the Raking method proved more profitable and sustainable than the Bulking method, and in fact allowed us to obtain a cyclic ovulation with a total regenerative capacity of the ovary of about 3/4 months, employing the same sea urchin batch in each productive cycle. In addition, the sea urchin caviar harvested in this way was appreciated by assessors in terms of its sensory qualities and was actually preferred to the traditional gonad products, when assessors were informed of the sustainability and ethical criteria of the Raking production method.
Influence of organic liquid fertilizer developed from livestock manure on the growth, antioxidant activities, and soil microbial populations of Chinese cabbage
Authors: Lee Junkyung , Jo Na-Yeon , Shim Su-Yeon , Le Tran Yen Linh , Jeong Woo Yong , Kwak Ki Wung , Choi Hyun Sik , Lee Byong-O , Kim Soo-Ryang , Lee Myung-Gyu , Hwang Sun-Goo
Published: June 2023

Background Effluents from livestock excretion have worldwide environmental disadvantages, such as air and water pollution. However, livestock manure and organic liquid fertilizers developed for the proper management of livestock excretions can be used as environmentally friendly fertilizers for sustainable agriculture. Therefore, we investigated the effects of organic liquid fertilizers on the growth and antioxidant accumulation in Chinese cabbage (Brassica rapasubsp.Pekinensis). Results Three liquid fertilizers, chemical liquid fertilizer (CLF), fermented liquid manure (FLM) from pig droppings, and liquid bio-fertilizer (LBF) fromChlorellacultured in purified organic liquid manure, were used in this experiment. Plant performance was observed and soil microbial changes caused by these liquid fertilizers were analyzed using 16S rRNA sequencing. We observed the highest plant growth in terms of plant length, chlorophyll concentration, width and length of leaves, and fresh and dry weights in the CLF group. LBF led to improved plant growth compared to FLM. Chlorophyll concentrations and color measurements of the plants were higher with LBF than with FLM. Interestingly, LBF affected plant substances with respect to sugar, ascorbic acid, and antioxidants in Chinese cabbage compared to CLF and FLM. The highest total polyphenol and flavonoid content, antioxidant activity, nitrite-scavenging capacity, and reducing power were observed in the LBF group. Significant changes in the bacterial population were observed in amplicon sequence variant analysis; the presence of Verrucomicrobia increased in soils after FLM and LBF treatments. LBF-treated soils had a higher abundance of Proteobacteria than FLM-treated soils. Conclusions We studied the effects of organic fertilizers across different liquid fertilizers on plant growth, antioxidants, and soil microorganisms. Especially, the LBF as organic bio-liquid fertilizer improved the plant growth and substances in Chinese cabbage under a controlled environment agriculture system. We have identified the specific bacterial species regarding the production process of liquid fertilizers in the change of soil microbial communities by the short-term experimental treatment. Thus, the proper development of organic bio-liquid fertilizer can contribute to the organic waste-recycling systems of livestock excretions for sustainable agriculture.
Protein language model powers accurate and fast sequence search for remote homology
Authors: Liu Wei , Wang Ziye , You Ronghui , Xie Chenghan , Wei Hong , Xiong Yi , Yang Jianyi , Zhu Shanfeng
Published: June 2023

Homologous protein search is one of the most commonly used methods for protein annotation and analysis. Compared to structure search, detecting distant evolutionary relationships from sequences alone remains challenging. Here we propose PLMSearch (Protein Language Model), a homologous protein search method with only sequences as input. With deep representations from a pre-trained protein language model to predict similarity, PLMSearch can capture the remote homology information hidden behind the sequences. Extensive experiment results show that PLMSearch improves the sensitivity of other sequence search methods by more than threefold, and is comparable to state-of-the-art structure search methods. In particular, unlike traditional sequence search methods, PLMSearch can recall most remote homology pairs with low sequence similarity but sharing similar structures. PLMSearch is freely available at https://issubmission.sjtu.edu.cn/PLMSearch.
HDAC6 inhibition to treat heart failure with preserved ejection fraction
Authors: Ranjbarvaziri Sara , Zeng Aliya , Wu Iris , Greer-Short Amara , Farshidfar Farshad , Budan Ana , Xu Emma , Shenwai Reva , Kozubov Matthew , Li Cindy , Pell Melissa Van , Grafton Francis , Mackay Charles , Song Xiaomei , Priest James , Argast Gretchen , Mandegar Mohammad , Hoey Timothy , Yang Jin
Published: June 2023

Heart failure with preserved ejection fraction (HFpEF) is a prevalent health condition associated with high morbidity and mortality, but currently, there are few effective therapies. Our previous research showed that inhibiting histone deacetylase 6 (HDAC6) had a beneficial effect on a genetic cardiomyopathy model. The overlapping underlying mechanisms involving inflammation and metabolism between cardiomyopathy and HFpEF prompted us to explore HDAC6 inhibition as a potential therapy for HFpEF. The results showed that the specific HDAC6 inhibitor TYA-018 improved heart function in mouse models of HFpEF, including a newly developed model that combines moderate trans-aortic constriction and high-fat diet to mimic the systemic and cardiovascular features of human HFpEF. In both models, inhibiting HDAC6 with TYA-018 reversed preexisting cardiac hypertrophy and diastolic dysfunction, and improved lung congestion and exercise capacity. The efficacy of TYA-018 was comparable to a SGLT2 inhibitor, and the combination showed increased effects. Mechanistically, TYA-018 restored expression of gene sets associated with hypertrophy, fibrosis, and mitochondrial energy production in heart tissue from HFpEF mice. TYA-018 also inhibited activation of human cardiac fibroblasts and increased mitochondrial respiratory capacity in induced pluripotent stem cell–derived cardiomyocytes. These findings support the direct role of HDAC6 on HFpEF pathophysiology in the heart and that inhibiting HDAC6 may be a promising approach to treating HFpEF.
Structure and Interactions of the Endogenous Human Commander Complex
Authors: Laulumaa Saara , Kumpula Esa-Pekka , Huiskonen Juha , Varjosalo Markku
Published: June 2023

The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis, cell cycle, and immune response. It consists of COMMD1-10, CCDC22, CCDC93, DENND10, and the Retriever sub-complex (VPS26C, VPS29, and VPS35L), all expressed ubiquitously in the body and linked to various diseases. Here, we report the structure and key interactions of the endogenous human Commander complex by cryogenic electron microscopy and mass spectrometry-based proteomics. The complex consists of a stable core of COMMD1–10 and an effector containing DENND10 and Retriever, scaffolded together by CCDC22 and CCDC93. We establish the composition of Commander and reveal major interaction interfaces. These findings clarify its roles in intracellular transport, and uncover a strong association with cilium assembly, and centrosome and centriole functions.
Diffusion Capability of Cs-137 in Compacted Soil and Bentonite Under Groundwater-saturated Condition
Authors: Salma Sufi Adzkia , Ekaningrum Nurul Efri , Pratama Hendra Adhi , Setiawan Budi
Published: June 2023

Several researches have been studied the diffusion coefficient (Da) of radionuclide in soil samples in varies location around the world; however, the effect of cations in groundwater as a medium of saturation for Cs-137 diffusion in soil and bentonite remains to be accomplished. Compacted soil and bentonite layers are utilized in the construction of radioactive waste disposal sites, which serve to prevent the release of Cs-137 from the repository to the unsaturated zone. The samples used were soil from the prospective disposal site in SP4 – Serpong Nuclear Center (SNC) and bentonite taken from Santrijaya, Tasikmalaya. The diffusion coefficient (Da) is used as indicator of Cesium-137 diffusion in the samples. Experimental measurements were conducted on a diffusion column unit that varied in diffusion time and density conditions to determine diffusion coefficients. The samples were cut into slices and analyzed using Multichannel Analyzer (MCA) unit to measure Cs-137 radioactivity. The measurement results were then incorporated into Fick's Law equation to obtain the value of the diffusion coefficient (Da) of Cs-137 in soil and bentonite. The experimental results showed that the diffusion coefficients of samples with groundwater simulation are in the range of 10− 12 m2.s− 1 for the local soil and bentonite samples, respectively. Compare to the similar experiment that was conducted previously, the results indicated that the groundwater content could slightly impact the increase in the diffusion coefficient value of Cs-137.
Cure Model for End-Stage Chronic Kidney Disease Patients at Benjamin Mkapa Hospital, Dodoma,Tanzania
Authors: Amani Zuberi , Gadde Srinivasa Rao , Abbas Ismail
Published: June 2023

This research intended to fit the cure model for end-stage chronic kidney disease (CKD) patients by using statistical computing methods, comparing the survival probabilities of CKD treatments and determining the influence of treatments’ sponsorship on the survival of CKD patients. The study used a dataset from Benjamin Mkapa Hospital (BMH) of end-stage CKD patients treated from 2018 to 2021 for a follow-up time of 172 weeks and an exponentiated half-logistic (EHLD) distribution used as baseline distribution in this cure model. The findings revealed that the cure probability for National health insurance fund (NHIF) sponsored patients were 46% and the cure probability for self-sponsored patients was 5%. Additionally, the median survival for NHIF-sponsored subjects was 48 weeks and for self-sponsored was 36 weeks. The cure fraction for NHIF-sponsored CKD patients was significantly higher than for self-sponsored patients. Therefore, treatment sponsorship was a significant factor in the survival of end-stage CKD patients. This is a call to government institutions and various health stakeholders to improve CKD awareness among Tanzanians and access to CKD treatments.
An invertible, invariant crystallographic representation for inverse design of solid-state materials using generative deep learning
Authors: Xiao Hang , Li Rong , Shi Xiaoyang , Chen Yan , Zhu Liangliang , Chen Xi , Wang Lei
Published: June 2023

The past decade has witnessed rapid progress in deep learning for molecular design, owing to the availability of invertible and invariant representations for molecules such as simplified molecular-input line-entry system (SMILES), which has powered cheminformatics since the late 1980s. However, the design of elemental components and their structural arrangement in solid-state materials to achieve certain desired properties is still a long-standing challenge in physics, chemistry and biology. This is primarily due to, unlike molecular inverse design, the lack of an invertible crystallographic representation that satisfies symmetry invariances. To address this issue, we have developed a simplified line-input crystal-encoding system (SLICES), which is a string-based crystallographic representation that satisfies both invertibility and symmetry invariances. SLICES successfully reconstructed 94.95% of over 40,000 structurally and chemically diverse crystal structures, showcasing an unprecedented invertibility. Furthermore, by only encoding compositional and topological data, SLICES guarantees symmetry invariances. We demonstrate the application of SLICES in the inverse design of direct narrow-gap semiconductors for optoelectronic applications. As a string-based, invertible, invariant and efficient crystallographic representation, SLICES has the potential to become a standard tool for in-silico materials discovery.
Prescribing exercise based on critical power is an effective way to control weight in adults with overweight or obesity: a scoping review
Authors: abedi-yekta amirhosein , aliabbar shiva , rabbni amirhassan
Published: June 2023

Background Obesity is considered one of the chronic diseases associated with an increased risk of mortality and morbidity. Nowadays, exercise is considered one of the most effective treatments for it. In recent years, various studies have been carried out to find the most effective exercise prescription. Objective The aim of this scoping review is to answer the question of whether increasing the intensity of exercise is an effective solution to weight loss in adults with overweight or obesity. Method systematic reviews and Meta-analyses from 2017 to 2022 investigated high-intensity interval training (HIIT) in adults (18–65 years old) with obesity or overweight included. The expected outcomes were weight, body mass index (BMI), and total and abdominal fat mass. Results A total of four systematic reviews which included 165 RCT and 4427 participants were included. Long term-HIIT was effective in decreasing body weight, body mass index (BMI), and total and abdominal fat mass. Conclusion HIIT is a time-efficient exercise prescription to reduce weight, BMI, waist circumference (WC), and total and abdominal fat mass, however, the outcomes were similar and no significant differences were found compared to moderate intensity continuous training (MICT). The lack of time can be compensated for by increasing the intensity, but this is not the most effective option with the most effects, so according to the physiology of exercise, perhaps the most effective solution for losing weight is to prescribe exercises tailored to each person's physiology and based on critical power.
Artificial intelligence-driven computer aided diagnosis system provides similar diagnosis value compared with doctors evaluation in lung cancer screening
Authors: Gao Shan , Xu Zexuan , Kang Wanli , Lv Xinna , Chu Naihui , Xu Shaofa , Hou Dailun
Published: June 2023

Objective
To evaluate the consistency between doctors and Artificial Intelligence (AI) software in analyzing lung nodules, and further compare the advantages of doctors and artificial intelligence in identifying benign and malignant lung nodules based on the pathological results as the gold standard.
Materials and methods
This retrospective study analyzed participants over 40 years old in the local place from 2011 to 2013. Pulmonary nodules were radiologically examined with a low-dose chest CT scan while being evaluated by a doctor expert panel of radiology, oncology, and thoracic department, and by a computer-aided diagnostic system driven by AI, respectively. Consistency tests were used to evaluate the consistency of the radiological features of the lung nodules. The Receiver Operating Characteristic curve(ROC) was used to evaluate the diagnostic efficacy. Logistic regression analysis was used to predict the possibility of lung cancer.
Results
Totally 570 subjects were included in this retrospective study. The AI software was very consistent with the panel's evaluation in the position and diameter of the lung nodules (kappa = 0.883, Concordance Correlation Coefficien(CCC) = 0.809, p = 0.000), and the consistency comparison of the solid nodules was acceptable in attenuation characteristics (kappa = 0.503); For patients diagnosed with lung cancer, the AUC of the panel and AI were 0.873 and 0.921, respectively, however, there was no significant difference (p = 0.0950). The diameter is a predictor of lung cancer in both panel and AI predictive models.
Conclusion
AI software can help doctors diagnose nodules and is consistent with doctors in differentiating between benign and malignant lung nodules.
Association between Tobacco Industry Interference Index (TIII) and MPOWER measures and adult daily smoking prevalence rate in 30 countries
Authors: Lee Yuri , Kim Siwoo , Kim Min Kyung , Kawachi Ichiro , Oh Juhwan
Published: June 2023

Background
This study aimed to investigate the impact of tobacco industry interference on the implementation and management of tobacco control and the tobacco epidemic using the Tobacco Industry Interference Index (TIII), and MPOWER—a package of measures for tobacco control—and adult daily smoking prevalence in 30 countries.
Methods
The TIII was extracted from the Global Tobacco Industry Interference Index 2019 and Global Center for Good Governance in Tobacco Control (GGTC). MPOWER measures and adult daily smoking prevalence rate were extracted from the World Health Organization (WHO) report on the global tobacco epidemic 2021. We assessed the ecological cross-lagged association between TIII and MPOWER scores as well as between TIII and age-standardized prevalence rates for adult daily tobacco users.
Results
Tobacco industry interference was inversely correlated with a country’s package of tobacco control measures (β=-0.088, P = 0.035). The TIII was correlated with weaker warnings about the dangers of tobacco (β=-0.016, P = 0.078) and lack of enforcement of bans on tobacco advertising promotion and sponsorship (β=-0.023, P = 0.026). In turn, the higher the TIII, the higher the age-standardized prevalence of adult daily smokers of tobacco for both sexes (β = 0.170, P = 0.036). Adult daily smoking prevalence in males (β = 0.417, P = 0.004) were higher in countries where the tobacco industry received incentives that benefited its business.
Conclusion
Where the interference of the tobacco industries was high, national compliance with the Framework Convention on Tobacco Control (FCTC) was lower and prevalence of adult daily smokers higher. National governments and global society need to work together to minimize the tobacco industry’s efforts to interfere with tobacco control policies.
Polarizability Matters in Enantio-selection
Authors: Chen Fumin , Chen Yu , Chang Xiao-Yong , He Dongxu , Yang Qingjing , Wang David Zhigang , Xu Chen , Yu Peiyuan , Xing Xiangyou
Published: June 2023

The origin of enantio-selection in chiral induction events is usually thought to be consequences of steric, electronic, or conformational effects. Polarizability, as a fundamental electronic property, has been well recognized for controlling molecules’ stability and chemical reactivity in the classic hard and soft acids and bases (HSAB) theory as well as modern density functional theory (DFT) frameworks. However, the underlying connection between polarizability and enantio-selection has long been largely overlooked. Uncovered herein is a new type of electronic effect based on polarizability that was shown to be well capable of rationalizing an extensive range of stereochemical observations made in the field of asymmetric catalysis. This effect provided a consistent enantio-control model for the prediction of major enantiomers formed in the ruthenium-catalyzed asymmetric transfer hydrogenations of ketones. Direct and quantitative linear free energy relationships between substrates’ local polarizabilities and observed enantio-selections were also demonstrated in three widely known asymmetric catalytic systems. This broadly applicable polarizability-based scenario helps shed new light on the nature of chiral induction, and it appears to be more effective factor governing both of the sense and magnitude of enantio-selection. A balanced consideration on such new polarizability effect, in conjunction with conventional wisdom mainly leveraging on steric effect considerations, should aid rational design of enantio-selective processes for better production of chiral substances.
Spatial transcriptome reveals disturbance of peri-infundibular immune infiltration in androgenetic alopecia
Authors: Charoensuksira Sasin , Tantiwong Supasit , Pongklaokam Juthapa , Hanvivattanakul Sirashat , Surinlert Piyaporn , Krajarng Aungkana , Thanasarnaksorn Wilai , Hongeng Suradej , Ponnikorn Saranyoo
Published: June 2023

Peri-infundibular immune infiltration (PII) is a crucial cluster of immune cells associated with human hair follicles (HFs), with potential importance in HF-immune interactions. Androgenetic alopecia (AGA) is characterized by microinflammation and abnormal immune responses, especially in the PII region. However, the precise patterns of immune dysregulation remain unclear due to limitations in current analysis techniques preserving tissue architecture. Here, we utilized spatial transcriptome profiling, a high-throughput analysis technology, to investigate the immunological disturbances within the PII region. We evaluated overall immune infiltrates, conducted gene set enrichment analysis (GSEA), cellular deconvolution, differential expression analysis, over-representation analysis, protein-protein interaction (PPI) network, and upstream regulator analysis to identify cell types and molecular dysregulation in immune cells. Our results demonstrated significant differences in immune signature between the PII of AGA patients (PII-A) and the PII of control donors (PII-C). PII-A exhibited enrichment in CD4 + helper T cells, distinct immune response patterns, and a bias toward the T helper (Th) 2 response. Immunohistochemistry confirmed the disturbed T cell subpopulations, with increased CD4 + T cells displaying elevated Th2 response but reduced Th1-cytotoxic response compared to PII-C. These findings reveal the unique immune landscapes of PII-A and PII-C, suggesting possibilities for the development of innovative treatment approaches.
SNAPSJIA study
Survey of Adolescents' Needs and Parents' Views on Sexual Health in Juvenile Idiopathic Arthritis
Authors: SAVEL Carine , CHAUSSET Aurélie , BERLAND Pauline , GUIGUET-AUCLAIR Candy , CABANE Laura , FAUTREL Bruno , GAUDIN Philippe , GUILLOT Pascale , HAYEM Gilles , LAFARGE Delphine , MERLIN Etienne , PEZIERE Nadine , SORDET Christelle , TROPE Sonia , TOURNADRE Anne , MALOCHET Sandrine , COHEN Jean David
Published: June 2023

Background: Although the advent of new therapeutics for juvenile idiopathic arthritis (JIA) patients has considerably lessened the impact of the disease and reduced sequelae, the outcomes of JIA remain important in their lives and more specifically for sex life. According to the world health organization, sexual health (SH) is "a state of physical, emotional, mental and social well-being in relation to sexuality". The aim of the study was to determine the expectations of adolescents with JIA and the perceptions of their parents regarding knowledge and communication with healthcare providers (HCPs) in the field of SH.
Methods: From September 2021 to April 2022, a French survey with anonymous self-administered questionnaires, was conducted among JIA patients and their parents in nine rheumatology centers and three patient associations. On the advice of a psychiatrist, we interviewed adults (age 18–45 years) for necessary hindsight from the subject.
Results: 76 patient and 43 parent questionnaires were analyzed. Half the patients thought JIA impacted their love life, the results were less clearcut for their sex life. 58.7% would be comfortable discussing the subject with HCPs, but only 26.3% had done so, mainly regarding biomedical issues. Patients and parents thought the topic should ideally be addressed in hospital in an individual patient education session (51.3%, 34.9% respectively), a regular consultation (47.4%, 53.5%) or a dedicated consultation requested by the adolescent without parents being informed (38.2%, 20.9%). Most thought HCPs should be proactive (77.6% of patients, 69.8% of parents). The use of digital resources was significantly more cited by patients than by parents: video information (29.0% vs. 9.3%, p= 0.0127) smartphone application (25.0% vs. 9.3%, p = 0.0372).
Conclusion: HCPs should address this unmet need for SH in hospital. The main difference between patients and parents was the use of digital tools, a preferred vector of communication for adolescents. Parents need to be reassured about their content.
Clinical trial registration number: NCT04791189
Whole genome sequence of Citrus yellow vein clearing virus CA1 isolate
Authors: Sun Yongduo , HelmRodriguez Sydney , Yokomi Raymond
Published: June 2023

Objectives:
Citrus yellow vein clearing virus (CYVCV) is an emerging disease that poses a significant threat to the citrus industry in California. In this study, the viral genomic RNA was isolated from Eureka lemon plants in the greenhouse exhibiting CYVCV symptoms. Subsequently, the corresponding DNA genome amplicon was sequenced and annotated. These efforts expand the genotype database of CYVCV, which aims to enhance detection assays, promote understanding of the virus's genetics and evolution, and support the management of this disease.
Data description:
In this report, we present the complete genome sequence of the CYVCV California isolate (CA1). The genome was found to be 7,530 bp in length, with a G+C content of 51.7%. The 5′ and 3′ termini were determined using 5′ and 3′ termini rapid amplification of cDNA ends (RACE) systems. Furthermore, our analysis revealed the presence of six open reading frames (ORFs) potentially encoding proteins. All sequence data and annotation have been deposited in GenBank under the accession number OR037276.
Inhibition and eradication effects of Thymus leptobotrys and Thymus satureioïdesessential oils against multidrug resistant Acinetobacter baumannii biofilms
Authors: Laktib Asma , Fayzi Lahbib , Megdar Soufiane El , Kheloui Raja El , Msanda Fouad , Cherifi Khalil , Hassi Mohammed , alla Aicha Ait , Hamadi Fatima
Published: June 2023

In the present study, the antibacterial activity of Thymus leptobotrys and Thymus satureioïdes essential oils was evaluated against nine multidrug resistant Acinetobacter baumannii strains. Besides, their inhibition and eradication effects were investigated, for the first time, against the biofilm form of the tested multidrug resistant bacteria. Gas chromatography–mass spectrometry analysis of the targeted essential oils highlighted the predominance of carvacrol and borneol, respectively. Their antibacterial activity test revealed considerable inhibition zones’ diameters (p < 0.05), ranging from 35 ± 1.4 to 43.6 ± 0.5 mm (Thymus leptobotrys) and from 16.6 ± 1.5 to 22 ± 2.8 mm (Thymus satureioïdes). Very low minimal inhibitory and bactericidal concentrations (p < 0.05) were also noted, varying from 0.78 to 12.5 mg/mL. Four strains out of nine (AB 6, AB 7, AB 8, AB 9) considered as the strongest biofilm producers by congo red agar and crystal violet methods, were chosen for the evaluation of biofilm inhibition and eradication effects of Thymus leptobotrys and Thymus satureioïdes essential oils. Great biofilm inhibition percentages were noted with 90.20% (Thymus satureioïdes) and 97.27% (Thymus leptobotrys) as the highest rates. Forty-eight hours biofilms were more resistant to the essential oils’ action. Low eradication proportions were observed ranging from 0–49%. Thus, Thymus leptobotrys and Thymus satureioïdes essential oils could be considered as a natural source of bioactive molecules and used as an alternative approach to prevent biofilm formation of multidrug resistant Acinetobacter baumannii.
Checklist of the Eunicidae Berthold, 1827 (Annelida) for the Iberian Peninsula (NE Atlantic)
Authors: Besteiro Celia , Parapar Julio , Moreira Juan
Published: June 2023

A checklist of the eunicids (Annelida: Eunicidae) reported in the Iberian Peninsula is presented based on published records. To date, 28 species have been reported belonging to 7 genera, being the most diverse Eunice Cuvier, 1817. Data is provided for each species regarding sampling locations, habitat, and depth.
IKZF1 rs4132601 and rs11978267 Gene Polymorphisms and Juvenile Systemic Lupus Erythematosus; relation to Lupus Nephritis
Authors: Mosaad Youssef M. , Hammad Ayman , Shouma Amany , Darwish Mohamed , Hammad Enas M. , Sallam Rehab AR. , ELTantawi Noha T. , Abdel-Azeem Heba A. , Youssef Laila F. , El-Khier Noha T. Abou , Fawzy Iman M. , Alwasify Mona
Published: June 2023

Background: The demographic factors, the socioeconomic status and the ethnicity of populations are important players that determine the incidence, the prevalence, and the spectrum of systemic lupus erythematosus (SLE) clinical presentations in different populations. Therefore, the purpose of the present research was to search for the presence of a relation between the IKZF1 rs4132601 and rs11978267 single nucleotide polymorphisms (SNPs) and the development of pediatric SLE (pSLE) and also to search for the association with the clinical presentations including lupus nephritis (LN).
Methods: After DNA extraction from EDTA blood samples for 104 pSLE patients and 286 healthy controls, the investigated SNPs (IKZF1 rs4132601 and rs11978267) were genotyped using TaqMan-Real-time PCR.
Results: The G allele and GG homozygous genotype of IKZF1 rs4132601 were associated with pSLE (p‹0.001, OR 2.97 and p‹0.001, OR 3.2 respectively). The GG and GA haplotype were more frequent in pSLE patients than other haplotypes (p‹0.001, OR 3.47, and p=0.001, OR=2.8 respectively). The studied SNPs have no impact on the different features of pSLE. The rs4132601 TG genotype was significantly associated with proliferative LN and class IV of LN biopsy (p=0.01, and p=0.029 respectively)
Conclusion: The IKZF1 rs4132601 can be considered a risk factor for SLE in the cohort of Egyptian children. The TG and GG genotypes of the IKZF1rs4132601 may predispose to proliferative LN.
A Novel Synchronized Stimulation Method to Improve the Tactile Localization Ability of Post-Stroke Patients
Authors: Rostami Mohammad , Barzegar Mojtaba , Ahmadi Maryam , Mehrpour Masoud , Nasimi Zahra , Attari Fatemeh , Saeedi Hamid , Bahmani Zahra
Published: June 2023

Background
Transcranial direct-current stimulation (tDCS) has shown promise in enhancing neural plasticity and functional abilities in post-stroke patients. However, determining the optimal protocol for this method remains an open question. Our study proposes a novel approach: synchronized stimulation that combines mechanical and electrical stimuli. We hypothesize that this approach will enhance tactile localization ability in post-stroke patients.
Methods
We recruited a total of 23 patients and conducted four different types of experiments involving periodic mechanical stimulation on their fingertips. The primary objective was to assess the participants' ability to accurately localize the location of the mechanical stimulation. In one experiment, only mechanical stimulation was administered. In the remaining three experiments, electrical stimulations were combined with the mechanical stimulation. The electrical stimulations comprised of one of the following protocols: (1) tDCS pulses administered solely for the initial five seconds of the session, (2) continuous tDCS pulses throughout the entire duration of the mechanical stimulation, and (3) tDCS pulses synchronized precisely with the timing of the mechanical stimulation.
Results
A noteworthy enhancement in tactile localization ability was observed when the electrical and mechanical stimulations were synchronized.
Conclusion
Our findings demonstrate that the integration of electrical brain stimulations with simultaneous mechanical stimulation of the fingertips resulted in enhanced neural activities. This synchronized integration holds the potential to improve perception and may serve as a vital approach in the treatment of post-stroke patients.