bluuebunny/crossref_metadata_2025 huggingface dataset:
DISCRIMINANT ANALYSIS OF THE TECHNICAL SHORT TEXTS
Authors: Borovsky Andrei Viktorovich , Rakovskaya Elena Evgenievna , Bisikalo Artem Leonidovich
Published: April 2018

Today much attention is paid to processing textual information in order to form thematic groups and to systematize documents. This is stipulated by growing popularity of the Internet as a means of communication and requires to categorize short technical texts, which, in turn, is characterized by complexity of traditional approaches - preprocessing and digitization of documents and identification of "classifying" features. Specificity of the study at each stage is determined by the characteristics of the texts - small size, similar vocabulary, a large number of highly specialized symbols and signs, synonymity of terms.There has been suggested the procedure of preparing texts for analysis, reducing the dimensions of "term-document" matrix using singular decomposition method which allows to solve the problem of small-rank approximation of the original matrix. There are classification methods used such as k-nearest neighbors method and discriminant analysis based on Fisher elementary functions (texts on assignment of instruments was taken as an example). The Fisher classification procedure uses discriminant variables and the approach of maximizing the differences between classes to obtain the classification function. An object belongs to the class for which the value of classifying function is the greatest. There has been given assessment of the results obtained and the inadequate accuracy of classification when applying TF-IDF measure under experimental conditions. To improve the quality of classification, a combined method has been proposed to select words at the first step using TF-IDF measure. The dictionary of terms and phrases is to be used at the second stage for classifying texts. According to the obtained data, it has been offered to carry out classification by discriminant analysis and k-closest neighbors method. The proposed combined method is planned to be refined and upgraded in the future.
INFORMATION SYSTEM DESIGNING METHOD FOR NON-CONFORMITY IDENTIFICATION IN THE PROCEDURES FOR MANAGING CORRECTIVE AND PREVENTIVE ACTIONS
Authors: Markosyan Mher Vardkesovich , Aghajanyan Ruben Borisovich , Baizhanova Dina Ondasinovna
Published: April 2018

Management of procedures for corrective and preventive actions is one of the main tasks for enterprises in such areas as biotechnology, food and pharmaceutical production. In practice, the process of detecting and identifying nonconformities is fraught with a number of difficulties due to the random nature of their occurrence and the length of the process of identifying the sources that generate these discrepancies. There has been presented a step-by-step process of detecting and identifying inconsistencies, based on the analysis and formal description of the corrective and preventive procedures. A method for classifying messages on inconsistencies coming from various sources and machine definition of key parameters for controlling process stability has been proposed. The principle of self-development of the computer system is implemented, which allows dynamically updating key parameters and calculating their reference values on the basis of empirical data and generated scoring context-sensitive tables. In particular, data granularity indicators, such as "frequency" and "number of registrations" are considered as such parameters and a practical example with a step-by-step description of the calculation of their values is presented. An approach to the automation of computing processes is proposed, by additionally taking into account aggregated variables, which are criteria for estimating key parameters. Practical use of this method allows real-time identification of inconsistencies and promptly conducting corrective and preventive actions to eliminate detected inconsistencies.
“If You’re a Parasite, Then You’re Not Normal”
Authors: Rivest Marie Pier , Roy Mélissa , Moreau Nicolas , Martel Aude , Negura Lilian , Nault Geneviève , Larose-Hébert Katharine
Published: May 2018

Previous research in sociology has shown that what is considered as sanity or mental health is described according to a social ideal. Mental health problems have been theorized as a deviance from such norms. Depression, in particular, has been the object of sociological contemplation due to its divergence from a Western social normativity focused on functionality, adaptation and productivity. This research adds to this body of work on depression as a deviation from social norms. It seeks to address a gap within the literature, by exploring the ways in which the “post-depressive” state may be defined in accordance with social norms. As such, it analyzes the links between “post-depression” and normality, from the perspective of individuals having lived with depression. 46 semi-structured interviews were conducted with Canadians individuals who have experienced depression. Results from our content analysis show that the absence of depression was often synonymous with normality and characterized by the following dimensions: a positive attitude; the potential to take action; functionality and performance; self-management; a positive relationship with others; and the notion of meaningful projects. Our results show that participants do not define the absence of depression following psychiatric or clinical indicators, as recorded in the DSM, and that they do not consider it to be a return to an anterior, pre-depression, state. Rather, post-depression is idealized, perceived as a state of unfailing conformity to social expectations and norms.
Por que reeditar (e reler) "O tratamento você em português: uma abordagem histórica"
Authors: Nunes de Souza Christiane Maria
Published: April 2018

O objetivo deste texto é discutir a importância e a vitalidade do texto clássico "O tratamento você em português: uma abordagem histórica", de Carlos Alberto Faraco, assim como justificar a necessidade de sua republicação.
The Kinetics of the Oxidation of Lysine by μ-Peroxo-Bridged Binuclear Cobalt (III) Complex of Succinimide in Aqueous Hydrochloric Acid Medium
Authors: Adetoro A , Idris S.O. , Onu A.D. , Okibe F.G
Published: May 2018

Kinetics of oxidation of Lysine (Lys) and mechanisms by μ-peroxo bis[bis(ethylenediamine)succinimidato-dicobalt(III)]dinitratedihydrate; [LCo(μ-O2)CoL](NO3)2.2H2O (L = suc(en)2), hereafter the complex, was investigated at 420 nm wavelength of maximum absorption of the complex under the conditions hydrogen ions concentration = 1.8 × 10-2 mol dm-3, temperature = 24 ± 1 °C, [LCo(μ-O2)CoL2+] = 1.4 × 10-4 mol dm-3 and ionic strength = 0.5 mol dm-3. First order in [LCo(μ- O2)CoL2+] and [Lys] were obtained but inverse first order in [H+]. The proposed overall rate equation is as shown:

Rate of the reaction decreases when hydrogen ions concentration increase and exhibited converse effect with increase in concentration of ionic strength from 0.1 - 1.3 mol dm-3. Added cations and anions affected the reaction rate and the Michaelis-Menten plot passed through the origin indicating no absence of intermediate complex in the electron transfer processes. Putting all the results obtained together, the most probable reaction mechanism is in favour of outer-sphere and an appropriate rate law is established using steady state approximation.
The Bacas and the Priests: How Old Adversaries Came Together to Revive and Reinterpret Tradition
Authors: Sendyka Pawel
Published: May 2018

In the Polish pastoralist tradition there have always been two seminal community events which bracketed the winter season. There was the autumn event of “Redyk Jesienny” when the sheep brought back from the summer alpine pastures were given back to their owners and there was also a spring “Redyk” also called “Mieszanie Owiec” which literally means the Mixing of Sheep. Historically, it was an important event in which the head shepherd, or the baca had to use his magical knowledge to ensure that the big herd made up of sheep from the individual owners would keep together as one and produce enough milk to make this summer venture profitable. To do that he used magic spells and performed rituals learned from his predecessors. The bacas' magical knowledge was frequently in opposition to the powers of the priests who viewed them with suspicion. Today, this spring event of “Mieszanie Owiec” is much changed. It is no longer a private affair of the baca and the sheep owners. Frequently, it is a public event, a tourist attraction, with the priests often taking centre stage. There is even a new, “invented” tradition of region wide “Mieszanie” at the sanctuary of Ludźmierz. There, a small herd of around 200 sheep is symbolically used to bless all the herds going up the mountain pastures for the season. The paper examines how these traditions changed from old ethnographic descriptions and how they are evolving in a modern economic and social reality.
Uji Efek Antidiare Kombinasi Ekstrak Biji Pepaya (Carica papaya L.) dengan Daun Kesumba Keling (Bixa Orellana L.) pada Mencit (Mus musculus)
Authors: Debora Novalia , Prabowo Wisnu Cahyo , Ibrahim Arsyik , Rijai Laode
Published: May 2018

Secara tradisional biji pepaya dapat dimanfaatkan sebagai antibakteri, mengobati gangguan pencernaan dan diare, sedangkan kesumba keling digunakan untuk mengobati penyakit lambung dan usus. Biji pepaya mengandung metabolit sekunder diantaranya tanin dan fenol, sedangkan pada tumbuhan kesumba keling, daunnya juga mengandung tanin, dimana kedua senyawa tersebut memiliki efek sebagai antidiare. Mengetahui efek kombinasi ekstrak biji pepaya (Carica papaya L.) dengan daun kesumba keling (Bixa orellana L.) sebagai antidiare pada mencit. Mencit dikelompokkan menjadi lima kelompok yaitu kelompok kontrol negatif yang diberikan CMC, kelompok kontrol positif yang diberikan Loperamid HCl dan tiga kelompok uji yang diberikan kombinasi ekstrak dengan tiga perbandingan dosis yang masing-masing diberikan secara oral. Oleum ricini digunakan sebagai penginduksi diare. Pengamatan menunjukkan bahwa kombinasi antara daun kesumba keling : biji pepaya mempunyai efek sebagai antidiare pada perbandingan 1:1 dan 1:2
Pengaruh Pemberian Leaflet dan Reminder Terhadap Outcome Terapi dan Kepatuhan Pasien Hipertensi Geriatrik di RSUD A. Wahab Sjahranie Samarinda
Authors: Utami Rinda Aulia , Annisa Nurul , Fitriani Victoria Yulita , Ramadhan Adam M.
Published: May 2018

Hipertensi merupakan salah satu masalah kesehatan masyarakat di dunia yang merupakan penyakit degeneratif yang berakibat polifarmasi. Tujuan penelitian ini adalah mengetahui pengaruh pemberian leaflet dan reminder terhadap ketercapaian outcome terapi dan kepatuhan pasien. Pemberian leaflet dan reminder merupakan salah satu upaya untuk meningkatkan efektifitas terapi dan kepatuhan pada pasien geriatrik. Penelitian ini menggunakan metode penelitian quasi experimental prospektif dengan teknik purposive sampling. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan dari pemberian leaflet dan reminder pada rata-rata perbandingan tekanan darah sistol sebelum dan sesudah dengan nilai p value yaitu 0,020 sedangkan pada rata-rata perbandingan tekanan darah diastol sebelum dan sesudah tidak terdapat pengaruh yang signifikan dengan nilai p value yaitu 0,173 dan tidak ada pengaruh yang signifikan dari pemberian leaflet dan reminder terhadap kepatuhan responden hipertensi geriatrik dengan p value yaitu 0,915. Pengontrolan gaya hidup pada pasien hipertensi geriatrik dengan pengaruh pemberian konseling tambahan dari apoteker diharapkan untuk dapat di teliti lebih lanjut.
Aktivitas Antioksidan Ekstrak dan Fraksi Kulit Batang Pila-Pila (Mallotus paniculatus) Terhadap 1,1-Diphenyl-2 Picrylhidrazyl (DPPH)
Authors: Junaid Riska Harfiani , Ardana Mirhansyah , Rijai Laode
Published: May 2018

Pila-pila merupakan tumbuhan yang dapat digunakan untuk pengobatan berdasarkan pengalaman empiris di Melak, Kutai Barat, yang kemudian diduga juga memiliki aktivitas antioksidan. Telah dilakukan penelitian mengenai aktivitas antioksidan dengan berbagai konsentrasi ekstrak metanol, fraksi etil asetat dan fraksi n-heksan kulit batang Pila-pila (Mallotus paniculatus). Ekstrak dan fraksi kulit batang Pila-pila diuji terhadap senyawa DPPH (1,1-difenil-2-pikril-hidrazil) dengan mengukur absorbansi menggunakan spektrofotometer sinar tampak pada panjang gelombang 516 nm. Variasi konsentrasi sampel uji yang digunakan pada pengujian ini adalah 20, 40, 60, 80, dan 100 ppm untuk ekstrak metanol dan fraksi n-heksan serta 10, 20, 30, 40, 50 ppm untuk fraksi etil asetat. Hasil penelitian menunjukkan bahwa ekstrak kulit batang pila-pila merupakan antioksidan kuat dengan nilai IC50 71.94 ppm, begitu pula fraksi n-heksan dengan IC50 59.92 ppm. Untuk fraksi etil asetat memiliki aktivitas antioksidan sangat kuat yaitu dengan nilai IC50 49.92 ppm.
(IC50 ekstrak metanol = 71.94 ppm, IC50 fraksi n-heksan = 59.92 ppm, IC50 fraksi etil asetat = 49.92 ppm).
Kandungan Metabolit Sekunder dan Uji Aktivitas Daun Pila-Pila (Mallotus paniculatus)
Authors: Dewi Sri Indah Mulyawan , Ardana Mirhansyah , Rijai Laode
Published: May 2018

Tumbuhan pila-pila (Mallotus paniculatus) adalah tumbuhan yang banyak digunakan oleh masyarakat suku dayak untuk mengatasi demam, diare, dan gatal-gatal pada kulit namun belum ada bukti ilmiah yang menunjukkan manfaat dari tumbuhan ini secara pasti di Indonesia sehingga penelitian ini bertujuan untuk mengetahui rendemen ekstrak, golongan metabolit sekunder, potensi toksisitas daun pila-pila terhadap Artemia salina Leach, dan potensi antioksidan daun pila-pila terhadap DPPH (2,2-difenil-1-pikrilhidrazil). Penelitian ini menggunakan metode maserasi dengan pelarut metanol untuk mengekstraksi daun pila-pila, metode BSLT (Brine Shrimp Lethality Test) serta  analisis Reed and Muench untuk mengetahui nilai LC50­ dan menggunakan metode peredaman terhadap DPPH serta analisis regresi linier untuk mengetahui nilai IC50 pada ekstrak metanol daun pila-pila. Hasil rendemen ekstrak adalah 28.5 % dan hasil identifikasi golongan metabolit sekunder ekstrak metanol daun pila-pila yaitu flavonoid, steroid, fenolik, dan alkaloid. Nilai LC50 ekstrak metanol daun pila-pila adalah 320,19 ppm dengan nilai r = 0,999 dan nilai IC50 ekstrak metanol daun pila-pila adalah 240,94 ppm dengan nilai r = 0,987.
Uji Aktivitas Antidiare Fraksi Etil Asetat Buah Libo (Ficus variegata Blume) pada Mencit (Mus musculus)
Authors: Sugipratiwi Utari , Maulidya Vina , Rusli Rolan
Published: May 2018

Tumbuhan libo bermanfaat sebagai obat karena mengandung senyawa aktif golongan flavonoid. Flavanoid dapat menghambat gerakan peristaltik usus sehingga dapat menghambat frekuensi defekasi, mengurangi sekresi cairan dan elektrolit. Penelitian ini bertujuan untuk mengetahui aktivitas fraksi etil asetat buah libo (Ficus variegata Blume) sebagai antidiare pada mencit (Mus musculus). Untuk memberikan kondisi diare, hewan coba diinduksi oleum ricini (minyak jarak) secara oral. Metode yang digunakan adalah metode proteksi terhadap minyak jarak. Hasil yang diperoleh menunjukkan bahwa fraksi etil asetat buah libo memiliki aktivitas sebagai antidiare.
Isolasi Senyawa Antioksidan dari Daun Pila-Pila (Mallotus paniculatus)
Authors: Maulida Wulan , Fadraersada Jaka , Rijai Laode
Published: May 2018

Pila – pila (Mallotus paniculatus) merupakan tumbuhan semak yang secara empiris digunakan sebagai antioksidan. Antioksidan adalah senyawa yang dapat menunda, mencegah atau memperlambat  reaksi oksidasi. Telah dilakukan penelitian mengenai isolasi senyawa dan uji antioksidan daun pila – pila. Penelitian ini  bertujuan untuk mencari eluen terbaik dalam pemisahan senyawa dari daun pila - pila menggunakan metode kromatografi lapis tipis (KLT) dan mengetahui aktivitas antioksidan pada senyawa tersebut. Sebanyak 10,0 g ekstrak metanol daun pila – pila difraksinasi dengan metode padat – cair dan didapat fraksi etil asetat, N-butanol, dan metanol. Uji antioksidan pada fraksi dilakukan menggunakan radikal 1,1-Difenil-2-Pikrilhidrazil (DPPH) 100 ppm dan dihasilkan fraksi setil asetat yang terbaik. Kemudian fraksi etil asetat diisolasi dengan metode kromatografi kolom menggunakan beberapa jenis eluen yaitu N-heksan:etil asetat (9:1;8:2;7:3), kloroform:metanol (9:1;8:2;7:3;6:4;5:5) dan metanol. Hasil isolasi diperoleh 9 kelompok sub fraksi. Pada sub fraksi 1 hingga 9 terdapat kristal yang telah diketahui eluen terbaiknya adalah N-heksan : etil asetat. Sub fraksi 1, 2, 3, 8, dan 9 memiliki aktivitas antioksidan yang ditandai dengan terbentuknya noda berwarna kuning pada plat KLT dengan latar berwarna ungu.
Kajian Karakteristik dan Pola Pengobatan Pasien Infeksi Menular Seksual di RSUD Aw Sjahranie Samarinda
Authors: Rahayu Yuniarti Pudji , Ramadhan Adam M. , Rijai Laode
Published: May 2018

Penyakit menular seksual adalah bagian dari infeksi saluran reproduksi yang disebabkan oleh bakteri, jamur, dan virus yang masuk dan berkembang biak di dalam tubuh yang ditularkan melalui hubungan seksual. Penelitian ini bertujuan untuk mengetahui karakteristik pasien, jenis-jenis penyakit infeksi menular seksual, dan pengobatan infeksi menular seksual. Metode ini dilakukan secara retrospektif dengan menggunakan hasil observasi. Hasil penelitian menunjukkan bahwa pasien infeksi menular terbanyak berjenis kelamin laki-laki yakni sebanyak 55 pasien (50,93 %), sedangkan 53 pasien (49,07 %) berjenis kelamin perempuan. Karakteristik pasien laki-laki penderita infeksi menular seksual mayoritas berusia pada masa dewasa awal, 26-35 (21,29 %), tingkat pendidikan SLTA (41,67%), pekerjaan sebagai karyawan swasta (34,26%), dan status belum menikah (27,78%). Sedangkan karakteristik pada pasien perempuan penderita PMS mayoritas berusia pada masa remaja akhir, 17-25 (22,22%), tingkat pendidikan SLTA (21,30%), pekerjaan sebagai IRT (25,93%), dan status menikah (36,11%). Jenis penyakit infeksi menular seksual dengan kasus terbanyak pada pasien laki-laki ialah Gonorrhea yakni sebanyak 24,07 %, sedangkan pada pasien perempuan ialah Kondiloma Akuminata yakni sebanyak 24,07%. Obat yang paling sering digunakan pada pengobatan Gonorrhea ialah Sefiksim  (38,71%), pada pengobatan Kondiloma Akuminata ialah Ciprofloxacin (28,57%), pada pengobatan Herpes Genital ialah Asiklovir (77,80%), pada pengobatan Candidiasis ialah Ketokonazol (100%), pada pengobatan Sifilis ialah Doxicyclin (66,67%), pada pengobatan Ulkus Genital ialah Ciprofloxacin (50%), dan pada pengobatan Trichomoniasis ialah Metronidazol (66,67%).
The Role of Maxims in The Process of Investigations: A Case Study in Situbondo Resort Police Office
Authors: Thahara Yopi , Firdaus Ahmad Yusuf , Amelia Firqo
Published: April 2018

This study aims to reveal the role of maxim in the conversation between the investigators and suspects in giving information during the making of investigation reports in Situbondo police office. This is an interdisciplinary linguistic research that utilizes linguistic and pragmatic disciplines. The theory used to analyze the data in this study is the theory of speech acts initiated by Searle. This is a qualitative descriptive research, and it produces deep descriptions of the words, writings, and behaviors that can be observed from a specific individual, group, society, or organization in a particular context that is holistically studied. The result of this research is the role of maxim in the process of investigation and the degree of the trustworthiness.
DYNAMICS OF INCIDENCE OF SEXUALLY TRANSMITTED INFECTIONS IN THE EVALUATION OF THE EPIDEMIOLOGICAL PROCESS AND STATE OF HEALTH OF THE RUSSIAN FEDERATION POPULATION IN 2006–2016
Authors: Kubanova Anna A. , Kubanov Alexey A. , Melekhina Lidiya E.
Published: April 2018

The paper presents the analysis of the incidence of sexually transmitted infections among the population  of the Russian Federation and among children age of 0–14 and adolescentsage of 15–17 in 2006–2016.
BENIGN LYMPHANGIOENDOTHELIOMA
Authors: Patrushev Aleksandr V. , Belousova Irena E. , Gorislavskaya Tatiana A. , Suharev Aleksey V. , Samtsov Aleksey V.
Published: April 2018

The authors describe modern data relating to the definition, clinical, pathological and immunohistochemical features of a rare vascular tumor — benign lymphangioendothelioma. The problems of differential diagnosis with Kaposi’s sarcoma and angiosarcoma are discussed. This is the first description of this tumorin domestic literature.
Analisis pelaksanaan manajemen Pemusatan Pendidikan dan Latihan Olahraga Pelajar (PPLOP) sepak takraw Jawa Tengah tahun 2017
Authors: Putra Andhika Yahya
Published: April 2018

Penelitian ini bertujuan untuk: (1) Mengetahui struktur organisasi PPLOP sepak takraw Jawa Tengah (2) Mengetahui proses tahapan yang dilakukan dalam perekrutan atlet di Pemusatan Pendidikan dan Latihan Olahraga Pelajar (PPLOP) sepak takraw Jawa Tengah. (3) Mengetahui manajemen sarana dan prasarana dalam mendukung prestasi atlet PPLOP sepak takraw Jawa Tengah. (4) Mengetahui pelaksanaan manajemen keuangan di PPLOP sepak takraw Jawa Tengah. (5) Mengetahui pelaksanaan manajemen latihan PPLOP sepak takraw Jawa Tengah. Penelitian dilaksanakan di Balai Pemusatan Pendidikan dan Latihan olahraga Pelajar (PPLOP) sepak takraw Jawa Tengah. Penelitian ini menggunakan metode diskriptif kualitatif. Unit anlisisnya  adalah Balai Pemusatan Pendidikan dan Latihan Olahraga Pelajar (PPLOP). Tehnik pengambilan data melalui studi dokumentasi, wawancara secara mendalam, dan observasi. Sumber data dalam penelitian ini adalah pengurus, pelatih dan atlet PPLOP sepak takraw Jawa Tengah. Hasil penelitian menunjukkan bahwa: pelaksanaan manajemen Pusat Pembinaan dan Latihan Olahraga Pelajar (PPLOP) sepak takraw Jawa Tengah pada umumnya sudah baik. (1) Struktur Organisasi PPLOP sepak takraw sudah sudah baik yang mana sudah memiliki unsur-unsur organisasi yang terus berupaya memfasilitasi atlet untuk berprestasi. (2) Proses perekrutan atlet sudah dilaksanakan dengan baik karena sangat selektif dan sudah sesuai dengan kriteria/bencmark yang ditentukan Kemenpora (3) Pelaksanaan manajemen sarana dan prasarana kurang baik, hal ini dikarenakan media pendukung fasilitas atlet PPLP belum lengkap sepenuhnya dan hanya memanfaatkan apa yang ada saja. (4) Pelaksanaan manajemen keuangan telah dilaksanakan dengan baik karena sudah sesuai dengan porsinya masing-masing. (5) Pelaksanaan manajemen latihan di Pusat Pembinaan dan Latihan olahraga Pelajar ( PPLOP) sudah perjalan dengan baik. Mengingat alokasi dana dari APBN dan ABPD  yang terbatas, sehingga pengelolaan hanya memaksimalkan dana yang ada.
Challenges of Connecting Chemistry to Pharmacology: Perspectives from Curating the IUPHAR/BPS Guide to PHARMACOLOGY
Authors: Southan Christopher , Sharman Joanna L , Faccenda Elena , Pawson Adam J , Harding Simon D , Davies Jamie A
Published: May 2018

Connecting chemistry to pharmacology (c2p) has been an objective of GtoPdb and its precursor IUPHAR-DB since 2003. This has been achieved by populating our database with expert-curated relationships between documents, assays, quantitative results, chemical structures, their locations within the documents and the protein targets in the assays (D-A-R-C-P). A wide range of challenges associated with this are described in this perspective, using illustrative examples from GtoPdb entries. Our selection process begins with judgements of pharmacological relevance and scientific quality. Even though we have a stringent focus for our small-data extraction we note that assessing the quality of papers has become more difficult over the last 15 years. We discuss ambiguity issues with the resolution of authors’ descriptions of A-R-C-P entities to standardised identifiers. We also describe developments that have made this somewhat easier over the same period both in the publication ecosystem as well as enhancements of our internal processes over recent years. This perspective concludes with a look at challenges for the future including the wider capture of mechanistic nuances and possible impacts of text mining on automated entity extraction
Kinetically Guided Radical-Based Synthesis of C(sp3)-C(sp3) Linkages on DNA
Authors: Wang Jie , Lundberg Helena , Asai Shota , Martín-Acosta Pedro , Chen Jason S. , Brown Stephen , Farrell William , Dushin Russell , O’Donnell Christopher J. , Ratnayake Anohka S. , Richardson Paul , Liu Zhiqing , Qin Tian , Blackmond Donna G. , Baran Phil
Published: May 2018

DNA-encoded libraries (DEL)-based discovery platforms have recently been widely adopted in pharmaceutical industry, mainly due to its powerful diversity and incredible number of molecules. In the past two decades since its disclosure, great strides have been made to expand the toolbox of reaction modes that are compatible with the idiosyncratic aqueous, dilute, and DNA-sensitive parameters of this system. However, construction of highly important C(sp3)-C(sp3) linkages on DNA through cross-coupling remains unexplored. In this article, we describe a systematic approach to translating standard organic reactions to a DEL-setting through the tactical combination of kinetic analysis and empirical screening with information captured from data mining. To exemplify this model, implementation of the Giese addition to forge high value C–C bonds on DNA was studied, which represents the first radical-based synthesis in DEL.
EFEITOS GENOTÓXICOS DO USO CRÔNICO DO FUMO NA MUCOSA ORAL.
Authors: Campos Amália Aparecida Busoni , Gonçalves Priscila Cristina , Noventa Maria Antonia
Published: May 2018

Este estudo teve como objetivo relacionar o uso do fumo com o aumento de quebras cromossômicas das células da mucosa oral em fumantes crônicos levando a riscos de surgimento de câncer bucal, pela técnica do micronúcleo. Diversos agentes atuam de forma genotóxica nas células e estão relacionados aos vários estágios da carcinogênese. Com relação à cavidade bucal, o fumo tem sido descrito como o principal fator de risco no desenvolvimento de lesões malignas e pré-malignas. A possibilidade de redução da incidência do câncer de boca está relacionada ao conhecimento e controle de fatores que são considerados de risco para o desenvolvimento da doença.  Os micronúcleos são porções de cromatina resultantes de mitoses aberrantes que permanecem próximas ao núcleo celular, e têm sido utilizados como marcadores para avaliar o grau de injúria genotóxica ao qual as células animais estão expostas. A amostra constou de células esfoliadas da língua e da mucosa jugal de 10 indivíduos fumantes e 10 não-fumantes. As células obtidas foram coradas pelo método de Feulgen e contracoradas por “Fast Green”. Observou-se um aumento estatisticamente significativo de micronúcleos em células esfoliadas dos indivíduos fumantes, o que permite sugerir que o hábito de fumar predispõe o indivíduo a danos genéticos que podem levar ao câncer bucal.
National outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to mixed salad leaves, United Kingdom, 2016
Authors: Gobin Maya , Hawker Jeremy , Cleary Paul , Inns Thomas , Gardiner Daniel , Mikhail Amy , McCormick Jacquelyn , Elson Richard , Ready Derren , Dallman Tim , Roddick Iain , Hall Ian , Willis Caroline , Crook Paul , Godbole Gauri , Tubin-Delic Drazenka , Oliver Isabel
Published: May 2018

We investigated a large outbreak of Escherichia coli O157 in the United Kingdom (UK) with 165 cases between 31 May and 29 July 2016. No linked cases were reported in other countries. Cases were predominately female (n = 128) and adult (n = 150), 66 attended hospital and nine had features of haemorrhagic uraemic syndrome. A series of epidemiological studies (case–control, case–case, ingredients-based and venue-based studies) and supply chain investigations implicated mixed salad leaves from Supplier A as the likely outbreak vehicle. Whole genome sequencing (WGS) indicated a link with strains from the Mediterranean and informed the outbreak control team to request that Supplier A cease distributing salad leaves imported from Italy. Microbiological tests of samples of salad leaves from Supplier A were negative. We were unable to confirm the source of contamination or the contaminated constituent leaf although our evidence pointed to red batavia received from Italy as the most likely vehicle. Variations in Shiga toxin-producing E.
coli surveillance and diagnosis may have prevented detection of cases outside the UK and highlights a need for greater standardisation. WGS was useful in targeting investigations, but greater coverage across Europe is needed to maximise its potential.
Compressive Strength by Incorporating Quarry Dust in Self-Compacting Concrete Grade M35
Authors: Ahmad Mushtaq , Ullah Sana , Manan Aneel , Odimegeu Temple Chimuanya , Beddu Salmia
Published: May 2018

The study has conducted to determine the workability and compressive strength of the self –compacting concrete. The sand has replaced with quarry dust with the proportion of 10, 20, 30 and 40% and super plasticizer was added 0.9%. The experiments were carried out at the Infrastructure University Kuala Lumpur (IUKL) concrete laboratory. Slump flow, J- Ring tests were carried out to determine the workability of self-compacting concrete and compressive strength test was conducted on 7 days and 28th days of curing period. A finding of the study shows that workability and compressive strength has increased by addition of quarry dust. It is concluded that addition of quarry dust up to 30%  improve the workability of the self-compacting concrete and further addition of quarry dust decrease the workability. Additionally, compressive strength of the quarry dust modified self-compacting concrete shows the trend of higher compressive strength up to 30% addition of quarry dust with sand replacement and further addition decrease the compressive strength.
Prinsip Desain Geometri Arsitektur Tadao Ando
Authors: Hassan Soraya Masthura
Published: April 2018

Geometry has shown that the architecture was an expression of man and a basic principle that were always presented on an architectural work. The research was conducted through two steps with the first step was to identified the Tadao Ando’s geometry design principle through a content analysis approach. Based on the textual review, Tadao Ando's geometry design principle was tend to select the simple geometric forms as the embodiment of the building shapes. An user spatial experiences were created through inter space relationships and interactions with the surrounding environment through the geometry and shape processing and became the central to his architectural work creation. In other words, pure geometry concept was the instrument to presented all of those. The second step was to compared Tadao Ando's geometry design principles in the monistic architecture to the pluralistic architecture catagories using a precedent analysis approach. The comparisons toward the geometrical principles were more complex and quite varied geometric shapes in pluralistic architecture while simple geometric shapes can be found in the monistic architecture,as well as interlinked circular paths in pluralistic architecture which shaped by the ‘direction wall’ rather than a simple circulation path in the monistic architecture, and the wall-formed angle was a multiple of 15° in monistic architecture but varying angles in the pluralistic architecture.
Analisis Efektivitas Program Promosi IMOVSES terhadap Tingkat Penggunaan Produk Microsoft Berlisensi pada Sivitas IPB
Authors: Sembiring Ifan Hernata , Munandar Jono M
Published: May 2018

Institut Pertanian Bogor (IPB) Microsoft Open Value Subcscription for Education Solution atau IMOVSES merupakan program promosi Microsoft yang dikelola oleh IPB dalam rangka memperkenalkan sekaligus meningkatkan penggunaan produk Microsoft berlisensi kepada sivitas akademika IPB dengan cara menawarkan produk Microsoft berlisensi dengan potongan harga yang signifikan. Tujuan penelitian ini adalah untuk mengidentifikasi karakteristik sivitas IPB terkait keputusan penggunaan software berlisensi, menganalisis respon sivitas IPB terhadap program promosi IMOVSES, serta menganalisis efektivitas penganggaran biaya program promosi IMOVSES. Metode yang digunakan untuk mengidentifikasi karakteristik sivitas IPB adalah chi square, untuk menganalisis respon sivitas digunakan EPIC Model dan Direct Rating Method, sedangkan untuk menganalisis efektivitas penganggaran promosi digunakan analisis regresi. EPIC Rate yang dihasilkan adalah sebesar 3,15, yang menunjukkan bahwa promosi berada pada rentang cukup efektif. Nilai direct rating (ǧ) diperoleh sebesar 64,14, yang menunjukkan bahwa promosi masuk dalam kategori baik. Persamaan regresi yang diperoleh adalah “Jumlah sivitas = 27,2+0,000027 Biaya promosi” yang menunjukan bahwa apabila biaya promosi ditambah sebesar Rp100.000,- akan menambah jumlah sivitas sebanyak 3 orang. Dibutuhkan setidaknya biaya sebesar Rp127.300.000,- untuk menjadikan program promosi efektif secara penjualan.
Evaluasi Peningkatan Kinerja Produksi melalui Penerapan Total Productive Maintenance di PT Xacti Indonesia
Authors: Livia Khalishah , Fewidarto Pramono D
Published: May 2018

Peningkatan kinerja produksi di industri manufaktur sangat penting dalam upaya peningkatkan produktivitas. Salah satu cara untuk meningkatkan kinerja produksi yaitu melalui penerapan Total Productive Maintenance (TPM). Tujuan penelitian ini, yaitu mengidentifikasi penerapan Total Productive Maintenance di PT Xacti Indonesia, menghitung kinerja produksi dengan menggunakan Overall Equipment Effectiveness (OEE), dan mengevaluasi faktor-faktor penyebab rendahnya kinerja produksi dan memberikan solusi perbaikan. Metode analisis data yang digunakan adalah Overall Equipment Effectiveness (OEE). Hasil dari penelitian ini, yaitu perusahaan telah menerapkan TPM, namun masih ada operator yang lalai dalam melakukan 5S dan pada implementasi pilar-pilar autonomous maintenance masih perlu dilakukan perbaikan. Rata-rata nilai OEE selama bulan Januari 2014 hingga Januari 2015 sebesar 70,4%. Rendahnya nilai OEE disebabkan oleh mesin sering mengalami idle, waktu siklus aktual mesin tinggi karena kurangnya kegiatan preventive maintenance, dan tingginya downtime. Solusi perbaikan yang diberikan yaitu memberikan training kembali kepada operator tentang 5S, meningkatkan kegiatan preventive maintenance secara benar, dan dibuatnya cleaning room untuk sedapat mungkin menghindari terjadinya breakdown mesin.
Peningkatan Kinerja Keuangan dan Harga Saham melalui Pengungkapan Penerapan Good Corporate Governance (GCG) dan Ukuran Perusahaan pada BUMN Go Publik
Authors: Hamdani Mailani , Nupikso Gunoro
Published: May 2018

Tujuan dari penelitian ini adalah untuk menganalisis bagaimana pengaruh pengungkapan penerapann Good Corporate Governance (GCG) terhadap kinerja keuangan Badan Usaha Milik Negara (BUMN) Go Public, menganalisis pengaruh pengungkapan penerapan GCG terhadap harga saham BUMN Go Public, menganalisis pengaruh ukuran perusahaan terhadap kinerja keuangan BUMN Go Public, dan menganalisis pengaruh ukuran perusahaan terhadap harga saham BUMN Go Public. Variabel dari penelitian ini adalah Pengungkapan penerapan GCG yang diukur berdasarkan Peraturan Menteri Negara Badan Usaha Milik Negara Nomor: PER-01/MBU/2011 tentang penerapan GCG di BUMN, ukuran perusahaan yang direfleksikan oleh total aset, kinerja keuangan yang direfleksikan oleh Return On Assets (ROA) dan Return On Equity (ROE), serta harga saham yang direfleksikan oleh return saham. Hasil dari penelitian ini adalah Pengungkapan penerapan GCG didalam laporan tahunan berhubungan signifikan terhadap harga saham. Pengungkapan penerapan GCG berhubungan signifikan terhadap kinerja keuangan. Ukuran perusahaan berhubungan signifikan terhadap harga saham dan ukuran perusahaan tidak berhubungan signifikan terhadap kinerja keuangan.
KEANEKARAGAMAN DAN KELIMPAHAN DIATOM (BACILLARIOPHYCEAE) DI PANTAI JERANJANG DESA TAMAN AYU KECAMATAN GERUNG KABUPATEN LOMBOK BARAT
Authors: Didik Santoso Hasanah Nurlaelatun, LaluJapa,
Published: April 2018

ABSTRAK Pantai Jeranjang yang terletak di desa Taman Ayu merupakan salah satu daerah buangan limbah cair karena terdapat PLTU (Pembangkit Listrik Tenaga Uap) yang menggunakan air laut sebagai pendingin dan akhirnya dibuang kembali ke laut. Tujuan penelitian ini yakni untuk mengetahui keanekaragaman dan kelimpahan diatom (Bacillariophyceae) di Pantai Jeranjang Desa Taman Ayu Kecamatan Gerung Kabupaten Lombok Barat. Metode penentuan titik sampling dan waktu sampling menggunakan purposive sampling method. Data diatom dianalisis untuk parameter indeks keanekaragaman, indeks kemelimpahan, indeks kemerataan dan nilai penting. Persen kesamaan antar stasiun ditentukan berdasarkan Bray Curtis Cluster Analysis menggunakan program biodiversity versi 2. Hasil penelitian menunjukkan spesies diatom yang teridentifikasi di Pantai Jeranjang terdiri dari 1 kelas, 2 ordo, 17 genus dan 26 spesies. Kemelimpahan spesies diatom di perairan Pantai Jeranjang sebesar 786,944individu/liter. Indeks keanekaragaman spesies diatom tergolong sedang yakni 1,383 dan kemerataan spesies diatom yakni 0,424 (penyebaran kurang merata). Hasil Bray-Curtis cluster analysis menunjukkan bahwa berdasarkan parameter biologi dan gabungan antara parameter bilogi dan parameter lingkungan, persen kesamaan tertinggi terdapat antara titik sampel I dan titik sampel II berturut-turut sebesar 78,781% dan 80,63%. Sedangkan berdasarkan parameter lingkungan persen kesamaan tertinggi terdapat antara titik  sampel I dan titik sampel III sebesar 99,030 %. Kata Kunci :Pantai Jeranjang, PLTU, Diatom ABSTRACTJeranjang coastal waters is a part of Taman Ayu village. The coastal waters of Jeranjang has been an area of liquid waste disposal of the Electric Steam Power Plant Jerajang. The purpose of this research were to know diversity and abundance of diatom (Bacillariophyceae) inthe coastal waters of Jerajang Taman Ayu village Gerung districts west Lombok. Sites and times of sampling were determined by using purposive sampling method. Data of diatom were analyzed for density,diversity, andevenness indexs and percentage important value. Percentage similarity of among stations was determined based on the Bray-Curtis cluster analysis using biodiversity program-version two. The results showed that diatom species of Jeranjang coastal waters consist of 1 class, 2 orders, 17 genus and 26 species. The abundance of diatom community in Jeranjang coastal waters was 786,944individu/liter. Diversity and evenness indexs of diatom species were 1,383 (intermediate status) and 0,424  (lack of dispersal). The highest percentage similarity was on biological parameters and the relationship between biological parameters and environmental parameters for between sample site I and sample site II (78,781% and 80,63%). Based of environmental parameters the percentage similarity of between sample site I and III was of 99.030%. Key words :Jerajang Coastal Water,Electric Steam Power Plant, Diatom
Winter den abandonment by brown bears Ursus arctos: causes and consequences
Authors: Swenson Jon E. , Sandegren Finn , Brunberg Sven , Wabakken Petter
Published: May 2018

Winter den abandonment by brown bears Ursus arctos in south‐central Sweden and southeastern Norway was found to occur in 9% of 194 bearwinters, based on 68 radio‐marked bears almost two years old and older. There was no statistical difference between the sexes, between adults and subadults, nor did protection from military or timber‐harvesting activities reduce the rate of abandonment. Although anecdotal, observations suggest that human disturbance was a major cause of den abandonment. Most abandonment occurred early in the denning period, before mid‐winter. Bears moved up to 30 km before denning again. Distance was not related to sex, age, or time of abandonment. Apparently for the first time, a fitness cost of den abandonment is documented: pregnant females that changed dens prior to parturition lost young in or near the den significantly more often than those that did not move.
Pengaruh Penambahan Dedak Padi Halus (Bekatul) dalam Ransum Terhadap Pertambahan Bobot Badan Ayam Broiler Periode Finisher
Authors: Purnomo Inggal , Aspirati Dyah Wahyuning , Dahlan Mufid
Published: April 2018

Penelitian tentang pengaruh tingkat penambahan dedak padi halus dalam ransum terhadap pertambahan bobot badan ayam broiler periode finisher di laksanakan pada tanggal 28 Mei sampai 20 Juni 2016 di peternakan milik Bapak. Abdul Majid Desa Waru, Kecamatan Mantup, Kabupaten Lamongan. Metode penelitian adalah Rancangan Acak Lengkap dengan empat perlakuan tiga ulangan, adapun 3 perlakuan dengan di tambah dedak padi halus (bekatul) P0 = 0% P1 = 5% P2 = 10% P3 = 15%. Penelitian yang diamati ini adalah konsumsi pakan. Pertambahan bobot badan dan konversi ransum, Dari hasil penelitian yang diperoleh rata-rata konsumsi pakan pada perlakuan P0 = 3231 (gram), tidak berbeda nyata terhadap perlakuan P1= 3232 (gram), P2 = 3250 (gram) dan P3 = 3243 (gram), Rataan pertumbuhan bobot badan selama penelitian pada perlakuan P0 = 1524 (gram), tidak berbeda nyata dengan perlakuan P1 = 1528 (gram), namun berbeda sangat nyata terhadap perlakuan P2 = 1601 (gram) dan P3 = 1572 (gram). Rataan konversi ransum selama penelitian pada perlakuan P0 = 2.11 (gram) berpengaruh tidak nyata terhadap perlakuan P1 = 2.11 (gram), P2 = 2.02 (gram) dan P3 = 2.06 (gram). Untuk mendapatkan biaya termurah, disarankan menambahkan dedak padi halus (bekatul) sebesar 15 persen dalam pakan jadi agar dapat mengurangi biaya pakan dalam pemeliharan ayam broiler priode finisher.Keywords: bekatul, ayam broiler, bobot badan
Colon targeted drug delivery system: A review on current approaches
Authors: Qureshi Altamash M. , Momin Munira , Rathod Sudha , Dev Asish , Kute Chaitrali
Published: May 2018

The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs i.e. peptides. Colon targeted drug delivery system (CDDS) is an Promising tool for treatment of inflammatory bowel diseases such as ulcerative colitis, crohn’s disease, colon cancer, amobebiasis by both systemic and topical delivery of dug. This article review a detailed study about disease of colon, diagnosis of diseases of colon, anatomy of colon, factors affecting drug absorption and different approaches of colon including some current approaches like Pulsinicap system, Port system, Probiotic approach, Chronotropic system, Colal-pred system, Enterion capsule Technology Muliparticulate system and some past studies on colon drug delivery with evaluation method for site specific drug delivery to colon.
Nelumbo Nucifera (Lotus): A Review on Ethanobotany, Phytochemistry and Pharmacology
Authors: Mehta Nishkruti R. , Patel Ekta P. , Patani Pragnesh V. , Shah Biren
Published: May 2018

Nelumbo nucifera Gaertn (Nymphaeaceae), a perennial aquatic plant, has been used as a medicinal herb in China and India. It has been recorded in the most famous medicinal book in China for more than 400 years. Different part of plant (leaves, seeds, flower, and rhizome) can be used in traditional system of medicine. In traditional system of medicine, the different parts of plant is reported to possess beneficial effects as in for the treatment of pharyngopathy, pectoralgia, spermatorrhoea, leucoderma, smallpox, dysentery, cough, haematemesis, epistaxis, haemoptysis, haematuria, metrorrhagia, hyperlipidaemia, fever, cholera, hepatopathy and hyperdipsia. Following the traditional claims for the use of N.nucifera as cure of numerous diseases considerable efforts have been made by researchers to verify it’s utility through scientific pharmacological screenings. The pharmacological studies have shown that N.nucifera posseses various notable pharmacological activities like amti-ischemic, antioxidant, anticancer, antiviral, antiobesity, lipolytic, hypocholestemic, antipyretic, hepatoprotective, hypoglycaemic, antidiarrhoeal, antifungal, antibacterial, antiinflammatory and diuretic activities. A wide variety of phytoprinciples have been isolated from the plant. The present review is an effort to consolidate traditional, ethnobotanic, phytochemical and pharmacological information available on N.nucifera.
Antimicrobial activity and Characterization of Marine bacteria
Authors: Jeganathan P. , Rajasekaran K. M. , Asha Devi N. K. , Karuppusamy S.
Published: May 2018

Marine bacteria were isolated from seawater was collected from different coastal areas of the Tamilnadu Sea. The antimicrobial activities of these bacteria were investigated. Ethyl acetate extracts of marine bacterial fermentation were screened for antimicrobial activities using the method of agar diffusion. The results showed that 25 strains of the isolates have antimicrobial activity. The proportion of active bacteria associated with isolated from seawater. The active marine bacteria were assigned to the genera Alteromonas, Pseudomonas, Bacillus and Marinobacter. The TLC autobiographic overlay assay implied that the antimicrobial metabolites produced by four strains with wide antimicrobial spectrum were different. These marine bacteria were expected to be potential resources of natural antibiotic products. It can be concluded that isolation of Marine bacterial samples can offer a numbers of microbial strains for sources of new biomolecules from Marine sources.
PENERAPAN ALGORITMA GREEDY DALAM MENENTUKAN MINIMUM SPANNING TREES PADA OPTIMISASI JARINGAN LISTRIK JALA
Authors: Didiharyono Didiharyono , Soraya Siti
Published: April 2018

This article discusses the applied of greedy algorithm principle in finding the optimum solution in determine minimum spanning tree on graph. Graph theory is one of the studies in discrete mathematics that are widely applied in various scope. This article is a literature study and applied of nets electricity network optimization using Prims algorithm and Kruskal algorithm. Network Nets System is one type of electrical network system construction. Based on results of the study and discussion can be concluded that the application of greedy algorithm using Prims algorithm and Kruskal algorithm in determine minimum spanning tree on its principle is the same. However, after a comparison between the two algorithms we consider that the ideal algorithm used to optimize the nets electric network is the Kruskal algorithm because in the case of the electric network has few sides and many vertices.
ANALISIS RAGAM DIALOG DIAGNOSIS PENYAKIT BERBASIS SPK MODEL TAM DENGAN SEMPLS
Authors: Justitia Putra Sandi , Budiarto Jian , Qudsi Jihadil
Published: April 2018

Decision Support System provides problem solving with semi structured and unstructured conditions. Decision Support System also has a role in the medical world, used in diagnosing diseases based on examination of patients. But often occurs less implementation due to the system interface interface that is not in accordance with the wishes of users. System interface interface tested there are 3 stages, namely anamnesis stage, physical examination stage, and examination. The choices given to the respondents are 3 interface design with various dialogue techniques for the anamnesis and physical examination phase ie Natural Language Process, Menu System and Filling Form and 2 interface design for supporting investigation ie Windowing System and Graphic Interaction. After the respondents made a choice on the questionnaire sheet, statistical tests were performed based on the Technology Acceptance Model. The result of the analysis shows the design according to the respondent's wishes on the decision support system to diagnose the disease at the anamnesis stage and physical examination stage is the design of the interface system with the filling form because of the larger R square model value at each stage of the interface design Natural Language Process and Menu System , while the supporting stage is the graphical interface interaction design on the graphical display, because of the larger R square model values ​​at each stage of the windowing system interface design.