bluuebunny/crossref_metadata_2025 huggingface dataset:
Mandado de Injunção - Direito de greve - Regulamentação
Authors: Silva Moacir Antônio Machado da
Published: August 2023

- Mandado de injunção. Direito de greve - Constituição. art. 37. VII. 2 - Legitimado está sindicato a requerer mandado de injunção. com vistas a ser possibilitado o exercício não só de direito Constitucional próprio. como dos integrantes da categoria que representa, inviabilizado por falta de norma regulamentadora. Precedente no Mandado de Injunção n. 347-5-SC.3 - Sindicato da área de educação de Estado-membro. Legitimidade ativa. 4 - Reconhecimento de mora do Congresso nacional, quanto à elaboração da lei complementar a que se refere o art. 37, VII. da Constituição. Comunicação ao Congresso Nacional e ao Presidente da República. 5 - Não é admissível, todavia, o mandado de injunção como sucedâneo do mandado de segurança, em ordem à anulação de ato judicial ou administrativo que respeite ao direito constitucional cujo exercício pende de regulamentação. Nesse sentido, não cabe mandado de injunção para impugnar o ato judicial que haja declarado a ilegalidade de greve no serviço público, nem por essa via é de ser reconhecida a legitimidade de greve. Constituição, art. 5º, LXXI. 6 - Mandado de injunção conhecido, em parte, e, nessa parte, deferido, para o fim acima indicado.
Instrução Normativa - Inconstitucionalidade - Compensação de contribuições
Authors: Pires Fleury
Published: August 2023

- A Suprema corte já declarou a inconstitucionalidade das alíquotas majoradas do FINSOCIAL (RE n. 150.764-1, rel. Min. Marco Aurélio, e RE n. 150.755-1, rel. Sepúlveda Pertence), como também já o fez este Tribunal (AI-AMS n. 38.950, reg. n. 90.03.42053-0, rel. Juíza Lucia Figueiredo.)- Se à Administração é dado estabelecer procedimentos internos, exatamente para que todos os contribuintes tenham igual tratamento, não menos verdadeira é a Çlssertiva que, se nem o regulamento, atribuição exclusiva do Presidente da República mercê do artigo 84, IV, da Constituição da República, pode alterar a lei acrescentando ou suprimindo determinadas possibilidades, a Resolução, Instrução, ou o que se chame, atos administrativos subalternos, hierarquicamente inferiores à lei e ao regulamento poderão fazê-lo. A Instrução Normativa n. 67, de 26-05-92, extrapolou sua competência de determinar procedimentos administrativos internos para boa concretização do desiderato legal. À autoridade administrativa compete sim a expedição de atos administrativos sub legem e, além disso, debaixo do regulamento, quando este existe, para que qualquer parcela de discricionariedade não sobeje a seus agentes, impedindo-se, dessarte, atitudes diversas de seus subordinados, em afronta ao princípio da igualdade.- Admissibilidade da compensação de Finsocial com Cofins. "No caso, a lei trouxe as condições a serem atendidas pelo contribuinte, ou seja, que o mesmo seja titular de um crédito relativo a pagamento indevido ou a maior de tributos ou contribuições, o qual poderá ser compensado no valor de recolhimento de importância correspondentes a períodos subseqüentes, ou seja, posteriores ao da ocorrência do fato gerador do tributo ou contribuição pago a maior ou indevidamente; que se tratem de tributos ou contribuições da mesma espécie, o que não significa devam ter o mesmo código de receita, porque não é o código de receita que fornece sua natureza jurídica: que o crédito seja corrigido com base na variação da UFIR, que foi instituída pelo art. lº da mesma Lei n. 8.383. " (REO n. 203.791, reg. n. 94.03.075709-4, rel. Juiz Homar Cais).- Não se pense que este Tribunal ao permitir a compensação esteja atribuindo ao contribuinte a "homologação" de seu pagamento, tal seja, declarar a extinção do crédito tributário. Isso. ao cabo do procedimento de compensação, caberá ao Fisco.
Contrato - Prorrogação tácita - Ilegalidade
Authors: Villaça Marcos Vinicios
Published: August 2023

- Prorrogação tácita de contrato administrativo equivalendo a contrato verbal é nula de pleno direito.
Cofins e empresa de construção imobiliária
Authors: Ataliba Geraldo
Published: August 2023

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Significação e alcance das "cláusulas pétreas"
Authors: Ferreira Filho Manoel Gonçalves
Published: August 2023

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O Judiciário a serviço da sociedade
Authors: Reale Miguel
Published: August 2023

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A reforma do Judiciário - A Jurisdição Constitucional na Revisão Constitucional de 1994 (Partes I e II)
Authors: Mendes Gilmar Ferreira
Published: August 2023

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Tribunal de Justiça - Número de Desembargadores - Constituição Estadual
Authors: Alvarenga Aristides Junqueira
Published: August 2023

- Tribunal de Justiça. Composição. Aumento de desembargadores pela Assembléia Constituinte Estadual independente de iniciativa do Judiciário. Inconstitucionalidade.- É inconstitucional o aumento do número de desembargadores sem proposta do Tribunal de Justiça. A regra, que decorre do princípio da independência e harmonia entre os poderes e é tradicional no direito republicano, aplica-se tanto à legislatura ordinária, como à constituinte estadual, em razão do que prescreve a Constituição Federal, art. 96, 11, "b" e "d".- Antiga controvérsia doutrinária e jurisprudencial.- Ação julgada procedente. Votos vencidos.
Crédito não tributário - Compensação - Proibição
Authors: Barbosa Alfredo Ruy
Published: August 2023

- É vedada a compensação de crédito não tributário em face do art., 54 da nº. 4.320/64.- O art. 170 do Código Tributário Nacional autorizou tão-somente a compensação de créditos tributários.
Empresa pública - Admissão de pessoal - Concessão de prêmio
Authors: Ghisi Adhemar Paladini
Published: August 2023

Ilegalidade de admissão de servidor, sem concurso público, a título de concessão ao Prêmio BNDES de Economia.
Os direitos fundamentais: Problemas jurídicos, particularmente em face da Constituição Brasileira de 1988
Authors: Ferreira Filho Manoel Gonçalves
Published: August 2023

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Ato administrativo "de ordem" - Delegação - Controle judicial
Authors: Mosimann Hélio de Melo
Published: August 2023

- O ato praticado "de ordem" resulta de delegação administrativa informal.- Compete à Justiça Federal de primeiro grau conhecer de Mandado de Segurança contra ato de delegado regional praticado "a ordem" do Ministro de Estado. Superior Tribunal de Justiça
Ministro de Estado - Crime de responsabilidade - Legitimação ativa
Authors: Mello Celso Antônio Bandeira de
Published: August 2023

Congressista em exercício do cargo de Ministro de Estado não goza de imunidade parlamentar.- Legitimidade ativa para iniciativa de crime de responsabilidade atribuído a Ministro de Estado Supremo Tribunal Federal
Servidor público - Irredutibilidade de remuneração - Limite de despesa
Authors: Mello Celso Antônio Bandeira de
Published: August 2023

Os partidos políticos têm legitimação ativa universal para propor ação direta de inconstitucionalidade.- Constitui ato normativo o decreto executivo que estabelece limite máximo de despesa para a folha de pagamento de servidores públicos estaduais.- A cláusula constitucional de irredutibilidade de vencimentos veda qualquer medida que importe em diminuição do valor nominal atribuído em lei a título de remuneração devida aos servidores públicos. Supremo Tribunal Federal
Previdência complementar - Fundos de pensão - Controle
Authors: Oliveira Paulo Affonso Martins de
Published: August 2023

- Situação do Sistema de Entidades Fechadas de Previdência Privada. Tribunal de Contas da União
Sociedade de economia mista - Subsidiária no exterior - Autorização legislativa
Authors: Dolinger Jacob
Published: August 2023

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A razoabilidade das leis
Authors: Tácito Caio
Published: August 2023

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Estado, sociedade civil e empresa: o papel das fundações de filantropia
Authors: Andrade Roberto Paulo Cezar de
Published: August 2023

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Banco estadual - Alienação de controle acionário - Autorização
Authors: Brindeiro Geraldo
Published: August 2023

- Relevância jurídica da impugnação de norma de constituição estadual, onde se contém proibição absoluta de alienação do controle acionário do Banco do Estado, emface de precedente do Supremo Tribunal (ADI 234, sessões de 22 de junho e de 4 de outubro de 1995), conferindo, a outro dispositivo da mesma Carta do Rio de Janeiro (aplicável às sociedades mistas em geral) interpretação conforme à Federal, no sentido de ser possível a alienação, desde quando  recedida de autorização legislativa, que se há de fazer por meio de leiformal (Constituição Federal, artigos 2ª,84, VI,37, IX, 173 e 174). - Relevância, igualmente, da contestação de dispositivo anciliar, que concentra, no mesmo Banco, a arrecadação e o processamento dos pagamentos do estado a terceiros (Constituição Federal, artigos 84, VI e 170, IV).- Medida cautelar deferida. Supremo Tribunal Federal
Crédito-prêmio - Isenção fiscal - Prescrição
Authors: Marques Cláudia Sampaio
Published: August 2023

Tribunal Regional Federal da 1ª Região
Magistrado - Auxílio-alimentação - Descabimento
Authors: Santos Homero
Published: August 2023

Tribunal de Contas da União
Regulamentação profissional - Princípio da razoabilidade - Desvio de poder
Authors: Mello Celso Antônio Bandeira de
Published: August 2023

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Privatização de serviços públicos: licitações e vendas de ações
Authors: Mukai Toshio
Published: August 2023

I - Introdução. A razão do presente estudo. II - Privatização e concessão ou permissão. Notas distintivas. III - As privatizações de serviços públicos e as legislações existentes a respeito. IV - Conclusões.
Interesse público: um conceito a determinar
Authors: Borges Alice Gonzales
Published: August 2023

1 - Conceitos Jurídicos indeterminados na moderna doutrina. 2 - Em busca de uma determinação do interesse público. 3 - Interesse público e interesse individual. 4 - Descompassos e conflitualidade na determinação do interesse público.
Servidor Público - Enquadramento - Concurso interno
Authors: Correa Affonso Henriques Prates
Published: August 2023

Inconstitucionalidade do art. 3º do ADCT da Constituição do Amazonas que autoriza efetivação dos servidores mediante concurso interno.
Ação Civil Pública - Ação popular - A defesa dos interesses difusos e coletivos - Posição do Ministério Público
Authors: Figueiredo Lucia Valle
Published: August 2023

1. Direitos coletivos e difusos. 2. Breve escorço histórico. O art. 6º do Código de Processo Civil. 3. A ação civil pública. 4. Legitimidade para agir na ação civil pública. 5. Da concessão da medida liminar. 6. O artigo 14 da Lei da Ação Civil Pública. 7. A tutela antecipada. 8. Responsabilidade na ação civil pública. 9. O Ministério Público na ação civil pública. 10. Conceito de patrimônio público e social - Eventuais desbordamentos da ação civil pública. 11. A ação popular: breves considerações gerais. 12. A legitimidade para agir. 13. Atos ilegais ou lesivos. 14. O patrimônio público defendido pela ação popular.
Servidor estadual - Reajuste de salário - Lei Federal
Authors: Nóbrega Haroldo Ferraz da
Published: August 2023

Direito do Trabalho: legislação federal sobre reajuste de salário ("gatilho salarial"): incidência direta sobre as relações contratuais trabalhistas do Estado-membro e suas autarquias. No âmbito da competência privativa da União para legislar sobre Direito do Trabalho - que abrange as normas de reajuste salarial compulsório - a lei federal incide diretamente sobre as relações contratuais dos servidores dos Estados, dos Municípios e das respectivas autarquias: uma coisa é repelir - por força da autonomia do Estado ou da vedação de vinculações remunetarórias -, que a legislação local possa atrelar os ganhos dos servidores estaduais, estatutários ou não, a vencimentos da União ou índices federais de qualquer sorte. Outra coisa bem diversa é afirmar a incidência direta sobre os salários de servidores locais, regidos pelo Direito do Trabalho, de lei federal sobre reajustes salariais: aqui, o problema não é de vinculação; nem de usurpação ou renúncia indevida à autonomia do Estado; é, sim, de competência da União para legislar sobre Direito do Trabalho.
Desapropriação por interesse social - Notificação prévia - Nulidade do decreto
Authors: Nóbrega Haroldo Ferraz da
Published: August 2023

- A propriedade selecionada pelo órgão estatal para o fim de desapropriação por interesse social visando à reforma agrária não dispensa a notificação prévia a que se refere o parágrafo 2º, do artigo 2º, da Lei n. 8.629, de 25 de fevereiro de 1993, de tal modo a assegurar aos seus proprietários o direito de acompanhar os procedimentos preliminares para o levantamento dos dados físicos objeto da pretensão desapropriatória. O conhecimento prévio que se abre ao proprietário consubstancia-se em direito fundamental do cidadão, caracterizando-se a sua ausência patente violação ao princípio do contraditório e da ampla defesa (CF, artigo 5º, inciso LV).- Não se considera prévia a notificação entregue ao administrador do imóvel "quando da vistoria".- Na falta da notificação prévia como preliminar do processo, o edito de expropriação por interesse social para os efeitos de reforma agrária torna-se plenamente nulo.
Autonomia universitária - Avaliação de qualidade - Princípio da razoabilidade
Authors: Saraiva Filho Oswaldo Othon de Pontes
Published: August 2023

- Constitucionalidade da lei criadora do Exame Nacional de Cursos Superiores.
Acesso à praia - Propriedade privada - Servidão de passagem
Authors: Tácito Caio
Published: August 2023

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As audiências e o processo administrativo brasileiro
Authors: Oliveira Gustavo Henrique Justino de
Published: August 2023

1. Considerações preliminares - 2. Estado de direito democrático - 3. Administração pública democrática - 4. Participação popular na Administração pública - 5. Processo administrativo. - 6. Audiência pública como instrumento de participação popular - 7. Audiência pública e processo administrativo - 8. Audiência pública e decisão administrativa - 9. Previsões legais - 9.1. O projeto de lei de processo administrativo - 10. Conclusões.
Comissão Parlamentar de Inquérito - Prazo certo - Depoimento de advogado
Authors: Silva Moacir Antônio Machado da
Published: August 2023

- A Comissão Parlamentar de Inquérito deve apurar fato determinado. c.F., art. 58, § 3º. Todavia, não está impedida de investigar fatos que se ligam, intimamente, com o fato principal.- Prazo certo: o Supremo Tribunal Federal, julgando o HC nº 71.193- SP, decidiu que a locução "prazo certo", inscrita no § 3º do artigo 58 da Constituição, não impede prorrogações sucessivas dentro da legislatura, nos termos da Lei 1.579/52.- A intimação do paciente, que é advogado, para prestar depoimento à CPI, não representa violência ao disposto no art. 133 da Constituição nem às normas dos artigos 87 e 89 da Lei 4.215, de 1963, 406, CPC, 154, Cód. penal e 207, CPP. O paciente, se for o caso, invocará, perante a CPI, sempre com possibilidade de ser requerido o controle judicial, os direitos decorrentes do seu "status" profissional, sujeitos os que se excederem ao crime de abuso de autoridade.- H. C. indeferido.
Contribuição social - Inadimplência - Serviço essencial sob monopólio
Authors: Santos Homero
Published: August 2023

- Empresa estatal prestadora de serviço essencial sob regime de monopólio, ainda que inadimplente junto ao INSS e ao FGTS, poderão ser contratadas pela Administração Pública.
Encontro de Tribunais de Contas em Cabo Verde
Authors: Souza Luciano Brandão Alves de
Published: August 2023

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O Mercosul e a competência do direito comunitário emergente
Authors: Bacellar Filho Romeu Felipe
Published: August 2023

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A prestação jurisdicional e a efetividade dos direitos declarados
Authors: Direito Carlos Alberto Menezes
Published: August 2023

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Servidor público - Aposentadoria especial - Art. 202 da Constituição
Authors: Batista Wagner Natal
Published: August 2023

-A cláusula normativa inscrita no art. 202 da Constituição não se reveste de auto-aplicabilidade, dependendo, para efeito de sua plena eficácia, da necessária intermediação do legislador, cuja intervenção se revela imprescindível à concretização dos elementos e critérios referidos no caput do preceito constitucional em causa. Precedentes.- A edição superveniente da Lei n. 8.2/2/91 e da Lei n. 8.2/3/91 viabilizou, de modo integral, a aplicabilidade dos critérios constantes do art. 202, caput, da Constituição, que define, "nos termos da lei", o regime jurídico concernente à aposentadoria previdenciária, por idade, instituída em favor dos trabalhadores urbanos e dos trabalhadores rurais. Como necessária conseqüência derivada da promulgação daqueles atos legislativos, tornou-se possível - a partir da data de sua vigência - o exercício do direito proclamado pela norma consubstanciada no art. 202 da Carta Política.
Nomeação - Requisitos - Razoabilidade
Authors: Brindeiro Geraldo
Published: August 2023

- Servidores públicos estaduais estatutários: ao Estado-membro cabe legislar, observados os princípios constitucionais federais relativos ao serviço público. Impertinência da invocação da competência legislativa da União inscrita no art. 22, I e XVI.- Pode o legislador, observado o princípio da razoabilidade, estabelecer requisitos para a investidura em cargo, emprego ou função pública. C.F., art. 37, I. Inocorrência de ofensa ao princípio da isonomia no fato de o legislador estadual ter exigido, para o movimento dos cargos de Auditor Interno, Escrivão de Exatoria, Fiscal de Mercadorias em Trânsito, Exator e Fiscal de Tributos Estaduais, que os candidatos fossem diplomados em Direito, Administração, Economia ou Ciências Contábeis.- Ação direta de inconstitucionalidade julgada improcedente.
Benefícios previdenciários - Atualização - Art. 58 do ADCT
Authors: Pinto Mardem Costa
Published: August 2023

- Benefício previdenciário. - Equivalência - Salário Mínimo. O preceito do artigo 58 do Ato das Disposições Constitucionais transitórias aplica-se aos benefícios previdenciários concedidos antes e após a promulgação da Carta tendo como termo final de incidência a data da vigência e eficácia do plano de custeio e benefícios que. por sinal. afastou do cenário jurídico efeitos financeiros (atualização) no período anterior - 1988 a 1991 (artigo 144 da Lei n. 8.213/91). Evolução de entendimento emface de melhor leitura e interpretação do preceito constitucional e consideração. ainda. o precedente do Plenário. exsurgido com o julgamento do recurso extraordinário n. 193.456-5/RS. do qual foi redator para o acórdão o Ministro Maurício Corrêa. em que assentada a constitucionalidade de dispositivo da Lei n. 8.213/91. vedador da eficácia retroativa.
Recursos minerais - Utilização direta pelos Municípios - Inconstitucionalidade
Authors: Barbosa Alfredo Ruy
Published: August 2023

- Não é válida a utilização direta de recursos naturais pelos Municípios para aplicação em obras públicas.
Αξιολόγηση μαθητών δευτεροβάθμιας εκπαίδευσης με δυσλεξία μέσω ηλεκτρονικού υπολογιστή
Authors: Παναγόπουλος Αντώνιος
Published: August 2023

Στην παρούσα διατριβή παραθέτετε ένα εργαλείο ανίχνευσης της δυσλεξίας σε μαθητές δευτεροβάθμιας εκπαίδευσης. Η ανίχνευση της δυσλεξίας στην συγκεκριμένηηλικιακή ομάδα έχει απασχολήσει τόσο διεθνείς όσο και ελληνικές έρευνες. Η έγκαιρη ανίχνευση της δυσλεξίας αποτελεί το ζητούμενο για τα παιδιά που εμφανίζουν δυσκολίες στην σχολική τους καθημερινότητα, καθώς η δημιουργία κατάλληλων στρατηγικών παρέμβασης, ενισχύει την σχολική τους επίδοση και ανεβάζει την αυτοπεποίθηση τους. Στόχος της παρούσας έρευνας είναι να εξεταστούν οι μαθητές που έχουν διαγνωστεί με δυσλεξία καθώς και οι τυπικά αναπτυσσόμενοι μαθητές σε διάφορους γνωστικούς τομείς.Οι δοκιμασίες, στις οποίες εξετάζονται οι μαθητές έχουν αποδειχθεί πειραματικάαπό διεθνείς έρευνες ότι συμβάλλουν στην έγκυρη και έγκαιρη ανίχνευση της δυσλεξίας σε μαθητές ηλικίας 12 έως 15 ετών. Συγκεκριμένα οι μαθητές εξετάστηκαν σε δοκιμασίες που αξιολογούσαν την αναγνωστική ικανότητα, την ορθογραφημένη γραφή, την οπτική ανάκληση, την οπτική διάκριση, την ακουστική ικανότητα, την μαθηματική ικανότητα, την λειτουργία την βραχύχρονης και μακρόχρονηςμνήμης και σε μια δοκιμασία που εξετάζει την νοητική τους ικανότητα. Η ιδιαιτερότητα του εργαλείου συλλογής δεδομένων είναι ότι μετρήθηκε ο χρόνος ολοκλήρωσης των δοκιμασιών και για τις δύο υπό εξέταση ομάδες. Στην έρευνα συμμετείχαν 360 μαθητές από Γυμνάσια του νομού Αττικής, οι οποίοιχωρίστηκαν σε δύο ομάδες. Η πρώτη ομάδα αποτελείτε από 180 μαθητές οι οποίοι έχουν διαγνωστεί με δυσλεξία από επίσημους φορείς του Ελληνικού κράτους (ΚΕΔΑΣΥ) και αποτελούν την πειρατική ομάδα. Η δεύτερη ομάδα είναι οι τυπικά αναπτυσσόμενοι και αποτελείται από 180 μαθητές που ανήκουν στην ίδια ηλικιακή ομάδα με αυτούς της πρώτηςομάδας και αποτελούν την ομάδα ελέγχου. Η συλλογή των δεδομένωνπραγματοποιήθηκε από την διαδικτυακή εφαρμογήDyscrete, η οποία αποτελείται από μια συστοιχία εννέα δοκιμασιών και εξετάζει τους γνωστικούς τομείς που αναφέρθηκαν πιο πάνω. Εν συνεχεία, πραγματοποιήθηκε στατιστική ανάλυση των δεδομένων. Από τα αποτελέσματα των δοκιμασιών προέκυψε το συμπέρασμα ότι οι μαθητές που είχαν διαγνωστεί με δυσλεξία παρουσίασαν στατιστικά σημαντικές διαφορές στους μέσους όρους της βαθμολογίας σε όλες τις δοκιμασίες, εκτός αυτής που εξετάζει την νοημοσύνη, καθώς οι μαθητές με δυσλεξία έχουν ίδια επίπεδα νοημοσύνης με τους τυπικά αναπτυσσόμενους συμμαθητές τους. Επιπλέον ίδια αποτελέσματα προέκυψαν στους μέσους όρους ολοκλήρωσης των δοκιμασιών, δηλαδή οι μαθητές με δυσλεξία ήταν πιο αργοί σε σύγκριση με τους τυπικά αναπτυσσόμενους συμμαθητές τους, με εξαίρεση την δοκιμασία που αξιολογεί την νοημοσύνη. Εν κατακλείδι, προκύπτει το συμπέρασμα ότι με την διαδικτυακή εφαρμογή Dyscrete, μπορεί να πραγματοποιηθεί με μεγάλη πιθανότητα η ανίχνευση της δυσλεξίας σε μαθητές δευτεροβάθμιας εκπαίδευσης. Επιπλέον, πρέπει να τονιστεί ότι η διαδικτυακή εφαρμογή Dyscrete έχει δημιουργηθεί για την ανίχνευση της δυσλεξίας και σε καμία περίπτωση δεν μπορεί να χρησιμοποιηθεί για την διάγνωση της.
A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications
Authors: Katsamenis Orestis L. , Basford Philip J. , Robinson Stephanie K. , Boardman Richard P. , Konstantinopoulou Elena , Lackie Peter M. , Page Anton , Ratnayaka J. Arjuna , Goggin Patricia M. , Thomas Gareth J. , Cox Simon J. , Sinclair Ian , Schneider Philipp
Published: August 2023

Background: The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront of developing three-dimensional (3D) imaging workflows using X-ray microfocus computed tomography (μCT) -based technology. This article presents the outcomes of these endeavours and highlights the distinctive characteristics of a μCT facility specifically tailored for 3D X-ray Histology, with primary focus on applications in biomedical research and preclinical and clinical studies.

Methods: The UHS houses a unique 3D X-ray Histology (XRH) facility, offering a range of services to national and international clients. The facility employs specialised μCT equipment designed specifically for histology applications, allowing whole-block XRH imaging of formalin-fixed and paraffin-embedded tissue specimens. It also enables correlative imaging by combining μCT imaging with other microscopy techniques, such as immunohistochemistry (IHC) and serial block-face scanning electron microscopy, as well as data visualization, image quantification, and bespoke analysis.

Results: Over the past seven years, the XRH facility has successfully completed over 120 projects in collaboration with researchers from 60 affiliations, resulting in numerous published manuscripts and conference proceedings. The facility has streamlined the μCT imaging process, improving productivity, and enabling efficient acquisition of 3D datasets.

Conclusions: The 3D X-ray Histology (XRH) facility at UHS is a pioneering platform in the field of histology and biomedical imaging. To the best of our knowledge, it stands out as the world's first dedicated XRH facility, encompassing every aspect of the imaging process, from user support to data generation, analysis, training, archiving, and metadata generation. This article serves as a comprehensive guide for establishing similar XRH facilities, covering key aspects of facility setup and operation. Researchers and institutions interested in developing state-of-the-art histology and imaging facilities can utilize this resource to explore new frontiers in their research and discoveries.
INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERS
Authors: Duskaev Galimzhan K. , Klimova Tatyana A.
Published: August 2023

Background. Coumarins are natural compounds (secondary metabolites of plant origin) that have a wide range of biological activity, mainly due to their ability to interact with various enzymes and receptors in living organisms. The relevance of their use in feeding poultry is obvious, in view of the active search for alternatives to feed antibiotics.

The aim of the study was to evaluate the effect of coumarin on the productivity and antioxidant status of broiler chickens.

Materials and methods. Objects of study: broiler chickens of the Arbor Acres cross, 7-hydroxycoumarin. The experiment was carried out on 180 heads of 7-day-old broiler chickens (n=45). Control - the main diet (OR), 1 experimental – OR + coumarin (at a dose of 1 mg/kg of feed/day, 2 experimental – OR + coumarin at a dose of 2 mg/kg of feed / day, 3 experimental – OR + coumarin in at a dose of 3 mg/kg feed/day. Hematological parameters (number and type of leukocytes) were taken into account on an automatic hematological analyzer URIT-2900 Vet Plus (URIT Medical Electronic Group Co., Ltd, China). Biochemical analysis of blood serum was performed on an automatic biochemical analyzer CS-T240 (Dirui Industrial Co., Ltd, China).

Results. The inclusion of 7-hydroxycoumarin in the diet contributed to an increase in live weight in the experimental groups by 8,6–19,4%; (by 9,2–21,1%), slaughter yield (up to 4,76%), against the background of a decrease in feed consumption per 1 kg of live weight gain (by 3,5–15,7%). showed a decrease in total protein, albumin, ALT (groups 1 and 2 (p≤0,05)), bilirubin (by 38,3–68,6%), cholesterol (in group 3 by 16,4% (p≤0,05)), triglycerides (groups 1 and 2, p≤0,05), urea (41,8–65,1%; p≤0,05), against the background of elevated iron levels (groups 1 and 2, p≤0,05). Depending on the dose of 7-hydroxycoumarin, a decrease in the number of leukocytes (group 1, p≤0,05), neutrophils (groups 1 and 2, p≤0,05), monocytes, eosinophils and basophils (p≤ 0,05). Antioxidant indicators were characterized by a decrease in the level of malondialdehyde (by 63,7–77,3%), superoxide dismutase activity (22,4–71,5%) and an increase in catalase activity (by 24,3–46,1%).

Conclusion. Thus, the inclusion of 7-hydroxycoumarin (2 mg/kg feed/day) in the diet contributed to an increase in the live weight of broiler chickens, feed intake, slaughter yield, against the background of a lower feed consumption per 1 kg of live weight gain; had a positive effect on the parameters of the liver (ALT, total bilirubin), lipid and nitrogen metabolism (triglycerides, urea), the antioxidant status of the body of broiler chickens.
MORPHOTYPIC COMPOSITION AND DIFENOCONAZOLE SENSITIVITY OF APPLE SCAB PATHOGEN POPULATIONS THAT DIFFER IN THE HISTORY OF FUNGICIDE APPLICATION
Authors: Nasonov Andrey I. , Bardak Mariya V.
Published: August 2023

Scab is one of the most harmful diseases of the world's main fruit crop, the apple tree.

Purpose. To evaluate the fungicide influence on the population structure of Venturia inaequalis, by its sensitivity to difenoconazole and morphotypic composition.

Materials and methods. The study was conducted on 88 monospore isolates isolated from two populations of V. inaequalis. The baseline population, which was not treated with fungicides, was selected from natural populations of Malus orientalis. A population of commercial apple orchards was treated with difenoconazole. The sensitivity of isolates was evaluated under laboratory conditions by mycelial growth at different fungicide concentrations and expressed as effective 50% concentration (EC50). Morphotypes were distinguished by comparing photo-images of isolates with morphotype images in a database.

Results. The populations differed in their sensitivity to difenoconazole at a high level of significance (p≤0.003), with median EC50 values of 0.5 and 2.5 mg a.i./l. The resistance factor of the orchard population had a value of 22. Morphological analysis of the isolates also showed an uneven distribution of morphotypes in the populations. Of the 15 morphotypes isolated, 73 % were unique to a particular population. A medium positive correlation between the traits "morphotype" and "fungicide sensitivity" was found.

Conclusion. For the first time, a change in the population structure of Venturia inaequalis under the influence of a fungicide was shown not only for a trait under selection pressure (sensitivity), but also for an evolutionarily neutral trait, morphotypic composition.
INFLUENCE OF TECHNOLOGICAL STRESS ON NON-SPECIFIC RESISTANCE OF THE ORGANISM OF COWS
Authors: Deryugina Anna V. , Ivashchenko Marina N. , Metelin Vladislav B. , Kovylin Roman S. , Ignatiev Pavel S.
Published: August 2023

Background. The intensification of animal husbandry leads to a violation of the adaptive capabilities of the body, a decrease in productivity and natural resistance of animals. The study of nonspecific factors of protection of the cow's body will allow us to develop ways to increase the immune status and as additional information can be used in breeding work for the selection of highly resistant parent pairs.

Purpose. The study of the cellular and humoral link of nonspecific resistance in the development of a stress reaction in cattle after the action of technological stress on the body of cows.

Materials and methods. The work was carried out on 20 clinically healthy highly productive black-and-white cows. The stressor for the cows was the regrouping, the change of attendants, the conduct of veterinary and sanitary manipulations. The total number of leukocytes, leukogram, bactericidal and lysozyme activity of the blood serum of cows were studied by standard clinical and laboratory methods and the morphology of leukocytes on a scanning electron microscope before and 3, 14, 30 days after technological stress.

Results. On days 3-14 after stress, leukocytosis, neutrophilia, monocytosis and lymphopenia were detected relative to the initial level. When using high-resolution microscopy using a scanning electron microscope, the appearance of NEToses in the blood of cows after technological stress was detected. A decrease in the bactericidal activity of serum on the 3rd day after stress with its subsequent increase was established, on the contrary, an increase in lysozyme on the 3rd day was accompanied by its subsequent decrease by 30 days after the technological stress relative to the initial level.

Conclusion. The data obtained indicate that the body's defenses are a dynamic physiological indicator, which must be considered as a general resistance of the cattle body to stressors in order to prevent the disruption of the body's adaptive capabilities.
IMPROVEMENT OF WORKING CONDITIONS IN RURAL AREAS THROUGH THE FORMATION OF INFRASTRUCTURE FOR AGRICULTURAL SERVICES
Authors: Kuts Vasily I. , Abushenkova Marina V. , Zhuravlev Pavel V. , Kurnosov Vladimir S.
Published: August 2023

Relevance of the study. The infrastructure of rural settlements has a significant impact on the quality of life of the rural population and, as a result, on the development of the infrastructure of the agro-industrial complex.

Objective. The purpose of this study is to develop scientific and methodological provisions for improving the infrastructure of agricultural services.

Materials and methods. The research methodology includes bibliographic analysis, as well as analysis of statistical data. To identify the most significant factors for ordinary agricultural workers, the method of expert assessments is used.

Results. Studies have been conducted on the agro-industrial complex organizations of the Altai Territory. The main part of the article identifies external and internal factors that determine the quality of working conditions in agriculture. Using the method of expert assessments, the most significant factors for ordinary agricultural workers were identified. In order to introduce digitalization in the agro-industrial complex, software and hardware unmanned complexes designed to perform certain functions in crop production are considered. Digital solutions designed to perform the functions of interaction with suppliers, consumers and transportation of agricultural products are described. The issues of environmental safety of workplaces in the agro-industrial complex are considered.

Conclusion. It is revealed that in order to effectively develop the infrastructure of rural settlements as a tool to improve the quality of life of the rural population, it is necessary to abandon the policy of maximum coverage in favor of a policy of concentrating efforts on a certain territory on the basis of a comprehensive plan covering all spheres of society and involving sectoral authorities in its implementation within a single project.
ELECTRICAL ACTIVITY OF THE HUMAN HEART DURING THE PERIOD OF VENTRICULAR DEPOLARIZATION UNDER ACUTE NORMOBARIC HYPOXIA
Authors: Zamenina Elena V. , Ivonina Natalya I. , Roshchevskaya Irina M.
Published: August 2023

Background. The effect of acute hypoxia on the human heart leads to deterioration of the heart function, this is reflected in an increase of the heterogeneity of the depolarization process, which is difficult to reveal when using a traditional ECG.

Purpose. To investigate the electrical activity of the heart during the ventricular depolarization on the thorax surface under the exposure of acute normobaric hypoxia using multichannel ECG mapping.

Material and methods. The electrical activity of the heart in apparently healthy young men (20±1 years) was studied during ventricular depolarization under exposure of acute normobaric hypoxia using cardioelectrotopography. Unipolar ECGs were recorded from 64 electrodes on the surface of the chest, simultaneously with bipolar ECGs in limb leads and the amplitudes of R and S waves from the surface electrodes localized in positions V1 and V5 of the traditional ECG were evaluated.

Results. It was revealed that during hypoxia, in comparison with the initial state, the pattern of distribution and the spatio-temporal dynamics of positive and negative cardiac potentials reflecting the sequence of myocardial activation on the torso surface did not change significantly and were typical for the period of ventricular depolarization of the healthy person. A decrease in the amplitudes of the maximum extrema of cardiac electric potentials, the amplitudes of the SV1 and RV5 waves at hypoxic exposure was revealed: the amplitude of the maximum decreased from 1.88±0.58 mV in the initial state to 1.83±0.55 mV at hypoxia, the minimum – from -2.08±0.76 mV to -1.85±0.73 mV, the SV1 wave from -1.28±0.25 mV to -1.17±0.18 mV, RV5 wave from 1.21±0.25 mV to 1.05±0.29 mV, respectively, while the duration of ventricular depolarization did not change statistically significantly.

Conclusion. Under hypoxic exposure, the examined persons showed a significant decrease in the amplitudes of the maximum extrema of the electric field of the heart, a direct correlation between changes in the amplitudes of the positive extremum and the RV5 wave, with practically unchanged duration of ventricular depolarization and dynamics of the distribution of cardioelectric potentials.
MODERN MODELS OF PERSONNEL INVOLVEMENT IN THE COMPANY
Authors: Kashtanova YEkatyerina , Lobacheva A. , Ashurbekov R.
Published: August 2023

The level of staff involvement is a very important tool for personnel management and business in general. It needs to be researched, improved and maintained to  ensure the growth of  companies. The article provides an  overview of  the main domestic and foreign models that allow assessing the state of  staff involvement, exploring the structure of involvement, finding its main bottlenecks and opportunities for development. The article examines the composition and focus of the Q12 Gallup engagement questionnaire, the model of Deloitte, McKinsey and other major companies, emphasizes the importance of creating a sense of employee belonging to the company and provides best practices of employee engagement, which are universal in nature, they can be implemented by many companies to improve their corporate culture and increase their own efficiency.
ORGANIZATION OF A WORKPLACE FOR REMOTE WORK IN MODERN CONDITIONS
Authors: Belova O. , Panin V. , Rudchenko P. , Artemova V.
Published: August 2023

This article discusses the problems of organizing jobs caused by a change in public consciousness, the introduction of new technologies in business processes, as well as extreme events, a pandemic, etc. The main trends characteristic of the process of organizing jobs at the present stage are highlighted, it is emphasized that in connection with the trends towards the harmonization of life and a healthy lifestyle, the extension of human life, the increase in the retirement age, the intensification of the struggle for talents, the rise in the cost of labor, the philosophy of organizing jobs is changing towards taking into account not only the requirements of the law, but also the recommendations of industrial medicine, occupational health, psychophysiology and ergonomics. The legislative documents that are the basis for the workplace equipment, as well as the results of a study aimed at studying the expectations of modern Russian personnel in the field of organizing workplaces for remote (remote) work of an office worker, are given.
DIGITAL TRANSFORMATION OF BRAND MANAGEMENT IN THE SYSTEM OF INTELLECTUAL ASSETS OF THE ENTERPRISE
Authors: Zakaryan Mikhail , Ziyatdinova V. , Kolesnichenko R.
Published: August 2023

At this moment, the whole world is experiencing rapid development of information and communication technologies, and our country is not an inclusion. Digitalization actively penetrates into various spheres of society and has a great impact on the work of various companies, organizations and institutions. The article examines the impact of digital technologies on brand management in the system of intellectual assets of the enterprise. Definitions of such concepts as «brand», «branding», «intellectual asset», «digital transformation», «brand management» are given, the strategic stages of brand management are covered in detail. The advantages of information and communication technologies for the development of brand management of the organization are noted and the importance of their application in the activities of the enterprise is emphasized. The article analyzes the changes from the point of view of the document-archival aspect that will occur in the organization with the digital transformation of brand management in the system of intellectual assets of the enterprise.
Effect of polycystic ovary syndrome on increased risk of cardiovascular disease
Authors: Maciak Anna , Pawłucki Piotr , Cuper Paulina , Sekuła Michał , Dziurowicz Błażej , Cuper Michalina
Published: August 2023

Introduction and purpose: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. It is a very complex disease in which hormonal disorders result in a number of metabolic dysfunctions and malfunctioning of the ovaries. This can lead to infertility, miscarriage and an increased risk of endometrial cancer. The aim of our work is to draw attention to the influence of PCOS on increased cardiovascular risk.

Brief description of the state of knowledge: The occurrence of PCOS, especially uncontrolled pharmacologically and non-pharmacologically, may be associated with an increased cardiovascular risk. The literature describes a higher incidence of dyslipidemia, carbohydrate metabolism disorders, obesity, hypertension, chronic inflammation and oxidative stress. As a consequence, it can lead to the development of metabolic syndrome. All these factors negatively affect the risk of developing cardiovascular disease. To prevent this, it is necessary to use appropriate pharmacological and non-pharmacological methods in women diagnosed with PCOS.

Conclusion: The mechanism of PCOS is complex and its development is influenced by genetic, endocrine, metabolic and environmental factors. The lack of proper diagnosis and the lack of treatment of PCOS is associated with numerous metabolic complications and an increased risk of cardiovascular diseases. Due to the poorly understood pathomechanism of this disease, further long-term studies are needed to help diagnose and treat PCOS.
IQOS - new heat-not-burn tobacco products and its impact on health
Authors: Jachowicz Krzysztof , Feja Krzysztof , Łuczak Ewa , Bieńkowski Borys , Petryla Piotr , Suwała Zuzanna , Korol Filip , Dobek Adam , Rektor Natalia , Symulewicz Michał
Published: August 2023

Introduction: Iqos and other heat-not-burn products according to tobacco companies are a safer alternative to cigarettes.

The aim of this article is to objectively review the potential impact of iQOS® on human health by searching for and integrating published research findings.

This article provides a comprehensive review and analysis of the scientific research conducted on the effects of Iqos use on human health, distinguishing between specific medical fields.

Materials and methods: This study is based on medical articles collected from the PubMed database spanning the years 2016-2023. The research was conducted through the analysis of keywords such as "Iqos", "Heat not burn", and "Iqos health impact". 

Results: Tobacco heaters are seen as potentially less harmful. However, emerging research on their harmfulness clearly shows that despite reduced concentrations of compounds hazardous to health, the aerosol produced by heaters still contains the same harmful substances. Further studies show that the toxic impact of the aerosol is at a similar level to that of smoke from traditional cigarettes.
O miejscu i czasie powstania Żywotu błogosławionego Romualda
Authors: Skwierczyński Krzysztof
Published: August 2023

Vita beati Romualdi by Peter Damiani (1007–1072) is one of the most interesting hagiographical works of the High Middle Ages, and at the same time a programme text of Romualdian monasticism. It is generally accepted that Damiani began work on the life at the Abbey of San Vincenzo di Petra Pertusa, where he had stayed for a few months in 1042, and completed the editing of the work already at the native Monastery of the Holy Cross in Fonte Avellana. This text proposes a new place and a new date for the start of work on the Vita beati Romualdi. During Damiani’s stay at Pomposa Abbey, the anti-Jewish treatise Antilogus contra Iudaeos was edited between 1040 and 1041. The publishers and translators of this work have failed to identify several quotations placed by Damiani in the treatise. These are excerpts from the Actus Silvestri, a record of a dispute between Pope Sylvester and the Jews, the Actus in turn being the second book of the Vita sancti Silvestri, probably written at the turn of the fifth century. References to this pope’s life can also be found in the ninth chapter of the Life of St. Romuald of Ravenna. It seems very likely, therefore, that Peter Damiani began work on the life of his spiritual master in the rich monastic library at Pomposa.
Ostatky, poutě a odpustky v českých cisterciáckých klášterech
Authors: Charvátová Kateřina
Published: August 2023

All medieval monasteries possessed relics, which were among their greatest spiritual treasures. The relics collected in Cistercian monasteries in Bohemia were quite abundant and included highly prized relics such as the thorn from Christ’s crown of thorns, part of the wood of the cross of Christ, the finger of John the Baptist and many others. The relics were kept in precious reliquaries, which visitors to the monastery were able to see and share in their sanctity under certain circumstances, for example during regular festivals. In the Middle Ages, relics were seen as a source of grace that helped all those who came near them. In addition, another form of forgiveness of sins was associated with them; they were seen as a source of indulgences, which were believed to have the ability to relieve the faithful of the torments of purgatory. Indulgences represented the remission of part of the temporal punishments for sins. They were granted for a certain number of days, e.g. a forty-day indulgence was to be effective to replace an equal number of days of penance. Soon, however, indulgences came to be understood as forgiving part of the stay in purgatory, so that the number of days of indulgence was seen as reducing the stay in purgatory by those days. In addition to pious attendance at church, the condition for the faithful to obtain an indulgence was to assist the monastery. The charters usually speak of a helping hand, but this most often means financial assistance, although there may have been other forms of support. Since indulgences were closely linked to donations, they were also seen as one of the sources of income for the monastery. The relics, festivals, pilgrimages and indulgences formed an interconnected chain, the purpose of which was, on the one hand, to care for the souls of the faithful, and, on the other hand, to benefit the monasteries economically, which benefited greatly from these activities. Every year they brought to the Cistercian abbeys many visitors who wanted to participate in the sanctity of the relics and enjoy the benefits of the indulgences they could obtain thanks to them.
Cysterki z Żarnowca i ich sąsiedzi do połowy XV w.
Authors: Kubicki Rafał
Published: August 2023

The elaboration presents the issue of relations of the Cistercians from Żarnowiec with their vicinity, i.e. possessors of surrounding lands, as well as a role played in these matters by the Teutonic Order. In the Middle Ages, the estates of the Cistercians’ monastery in Żarnowiec constituted a dense complex of domains located in the northern part of Gdańsk Pomerania. The complex reached the coasts of the Baltic See. The relations of the monastery with surrounding knighthood concerned mainly issues of purchase, records and demarking of domains. In this context, neighbourly conflicts arose oft between the two parties. In the case of the Teutonic Order, its representatives – the commander in Gdańsk, the fish master (German: Fischmeister) in Puck, or finally the Grand Master – acted both as referees and parties in border conflicts with the monastery. Officials of the Teutonic Order confirmed purchase transactions made by nuns with surrounding knight hood, and the Grand Master himself decided about handing over a parish in Puck to the Cistercians, which became a reason of their conflicts with local parsons. In the case of quarrels with the Teutonic Order, the sisters searched usually for help at representatives of the Gdańsk authorities. The sisters’ relations with the abbot in Oliwa constituted another problem. In the first half of the fifteenth century, the prioress acted somewhat independently, which was manifested in her direct contacts with the Grand Master. However, it is not known if this situation mean the deliberate endeavours of the prioress and convent in Żarnowiec to become independent from the power of the abbey in Oliwa as far as the property questions are concerned, or it was the initiative and action of the Teutonic Order, which could strive for loosening the real connections of the monastery with the abbey in Oliwa, for example through handing over a parish in Puck to the sisters.