bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful Isavuconazole Salvage Therapy for Cerebral Mucormycosis in A child With Relapsed Leukemia, A light in The Dark Tunnel
Authors: Balsara Karl , Alali Muayad , Khaitan Alka , Streicher Drew , Budnick Hailey , Schulte Rachael
Published: January 2024

Mucormycosis is an angioinvasive lethal fungal infection in pediatric
cancer patients. We present 10-year-old female with relapsed B-cell
acute lymphoblastic leukemia undergoing chemotherapy was diagnosed with
isolated cerebral mucormycosis (ICM). Despite surgical debridement and
liposomal amphotericin B, repeat imaging showed concern for disease
progression. Chemotherapy was discontinued and the patient was
discharged on salvage therapy oral isavuconazole (ISAV). Over two months
later, the patient was unexpectedly clinically stable, and imaging
showed near resolution. After confirming continuous disease remission,
the patient was restarted on modified chemotherapy. Serial MRI’s during
continued chemotherapy showed stable MRI findings. This case illustrates
a rare presentation of successful salvage monotherapy ISAV for this
deadly infection with complete remission for relapsed leukemia.
Unusual case of pneumoperitoneum secondary to ruptured pyogenic liver abscess
Authors: CHALH OLAIA , Boularab Jihad , Sibbou Khaoula , Ennafaa Issam , Fenni Jamal El
Published: January 2024

The rupture of gas-forming pyogenic liver abscess is a life-threatening
complication especially in elderly patients. It’s an unusual cause of
pneumoperitoneum which most commonly occurs by perforation of a hollow
viscus. Computed tomography is the key of accurate diagnosis. It may
rule out differential diagnosis and helps guide percutaneous drainage.
Association between use of romosozumab and cardiovascular events: analysis of the Japanese Adverse Event Report database
Authors: Kotake Kazumasa , Mitsuboshi Satoru , Omori Yuki , Kawakami Yukio , Kawakami Yasuhiro
Published: January 2024

There is concern about an increased risk of cardiovascular events in
romosozumab users. This study evaluated the association between use of
romosozumab and cardiovascular events using the Japanese Adverse Drug
Event Report database. In total, 868 romosozumab users were identified.
Disproportionality of cardiac events (reporting odds ratio [ROR]:
11.5, 95% confidence interval [CI]: 8.58–15.2; P < 0.01)
and cerebrovascular events (ROR: 7.03, 95% CI: 5.46–8.93; P
< 0.01) was observed. Cardiac events were significantly
increased in patients with cardiac disease (odds ratio [OR]: 2.74,
95% CI: 1.37–5.49; P < 0.01), hypertension (OR: 1.97, 95%
CI: 1.07–3.63; P = 0.03), and diabetes (OR: 2.36, 95% CI: 1.16–4.80;
P = 0.02). Similar results were found regarding the risk factors for
cerebrovascular events. This study suggests that comorbidities such as
hypertension and diabetes may increase the risk of cardiovascular events
in romosozumab users.
Mathematical Model and Analysis of Impetigo Transmission Dynamics
Authors: Fantaye Abayneh Kebede
Published: January 2024

In this paper, we develop and analyze a mathematical model for impetigo
transmission dynamics. The basic reproduction number, R0, is calculated
using the next-generation matrix approach. The disease-free and endemic
equilibrium, as well as the basic features of the model, were
investigated. When R0 < 1, the model’s stability analysis
reveals that the system is asymptotically stable at disease-free
equilibrium both locally and globally. Disease-endemic equilibrium
exists when R0 > 1, and the system is asymptotically stable
at disease-endemic equilibrium both locally and globally. The long-term
behavior of the impetigo model’s steady state solution in a population
is investigated using numerical simulations of the model.
Maternal morbidity and mortality associated with mode of delivery in Sickle cell disease: an observational study
Authors: Martinborough Tracey , Allen-Davis Wendy , Hunter-Greaves Tiffany , Thame Minerva , Reid Marvin , Simms-Stewart Donnette
Published: January 2024

Objective: To compare pregnancy outcomes based on mode of delivery in
women with homozygous sickle cell disease (HbSS) to women without
(HbAA). Design and setting: Retrospective observational study was
performed using delivery records of 48,600 parturients between January
1992 and January 2020 at a Jamaican hospital. Methods: We identified 250
women with HbSS and 252 age-matched with AA phenotype. Stratification
based on mode of delivery revealed: 150 vaginal and 105 caesarean
deliveries (HbSS), 185 vaginal and 67 caesarean deliveries (HbAA).
Fisher’s exact tests and Mann-Whitney test were used to analyze
variables based on sickle cell status. Unadjusted and adjusted odds
ratios were calculated based on mode of delivery. Main outcome measures:
Maternal and perinatal morbidity in women with HbSS and HbAA genotypes
exposed to vaginal or caesarean section delivery. Results: Vaginal
delivery and HbSS were more associated with labour
induction/augmentation (AOR= 2.4, (0.7–7.8)), intrapartum complications
(AOR= 2.6, (0.5–14), postpartum hemorrhage (AOR= 2.8 (0.5–15.2)), and
postpartum infections (AOR= 9.6 (1.7–54.4)). Caesarean delivery
resulted in more postpartum infections in the HbSS group (AOR = 23.6
(0.9 – 638.4)). There were no differences in rates of neonatal deaths
(n (%); 3 (4) vs. 0(0), p=0.250); or stillbirths between the groups.
Conclusion: Vaginal delivery in HbSS resulted in more intrapartum
complications, postpartum hemorrhage, hypertensive disorders, and
postpartum infections. Cesarean delivery in HbSS increases the risk of
postpartum infections and hypertensive disorders. There was no increased
risk of adverse perinatal outcomes regardless of mode of delivery.
A Case of Recurrent Stroke and Frequent TIAs: to Explore the Mechanisms and Antiplatelet Regimen
Authors: CUI Xiaoyan
Published: January 2024

We report a case of recurrent stroke and frequent TIAs to explore the
underling mechanisms of her repeated episodes of TIAs and tailored
efficient antiplatelet regimen.
Contribution of three dimentional echocardiography Xplane mode in the evaluation of semilunar cusps: two different case reports
Authors: Aktemur Tugba , Karakurt Seda Tukenmez , karakurt huseyin , Güler Arda , Guler Gamze Babur
Published: January 2024

Orthogonal-biplane imaging (xplane) is a relatively new tool and
provides comprehensive information about mitral valve and left atrial
appendage evaluation. On the other hand, x plane method is a promising
method in diagnosis of semilunar valve pathologies. Below, we report two
cases, in which xplane method was used in order to clairify diagnosis.
Case 1 : 63 year old male patient with dyspnea admitted to our clinic.
Right ventricular dilatation and hypertrophy were assessed. In order to
determine the exact reason of right ventricular pressure overload,
pulmonary valve was evaluated by xplane and bicuspid pulmonary valve was
represented.This patient has been undergone to pulmonary valve
percutaneous valvuloplasty. Case 2 48 year-old male patient with historu
of cerebrovascular event was admited to our hospital. His initial
transthorasic and transoesaphageal echocardiography showed hyperechoic
mobile mass on non-coronary cusp. However, after xplane was used to
detect aortic valve,it was the prolapsed part of the non-coronary cusp
adjacent to  the commissure.
High-quality and sustainable development of soil and water conservation vegetation
Authors: guo zhongsheng , Chen Dandan , zhang wenwen
Published: January 2024

The effect of vegetation on soil and water conservation increases with
the increase of planting density. At the same time, the degree of soil
drought increases with the increase of planting density, and leads to
the decline of vegetation or waste resources and then affects the
benefit of vegetation on soil and water conservation. However, there is
a few research of high-quality sustainable management of easier degraded
soil and water conservation vegetation ecosystems. In this paper, the
high-quality sustainable management of soil and water conservation
vegetation was reviewed. The results showed that the degree of cover of
soil and water conservation vegetation increases with increasing density
under other things being equal; the canopy interception increases with
stand density but there is a peak value of canopy interception. The
surface runoff decreases with increasing density with a logarithm
relationship; the sediment charge in the runoff increases with reducing
density with a logistic relation. There is a limit of soil and water
conservation vegetation, which is the cover degree of soil and water
conservation vegetation when the existing plant density of indicator
species in a plant community is equal to vegetation carrying capacity.
When plant density of indicator species in a plant community is more
than vegetation carrying capacity, the cover degree of soil and water
conservation vegetation is more than the vegetation restoration limit of
soil and water conservation vegetation, the plant resources relationship
should be regulated based on vegetation carrying capacity to realize
high-quality sustainable management of soil and water conservation
vegetation.
Astragaloside trigger autophagy via inhibiting the Ras/Raf/MEK/ERK signaling pathway in pulmonary fibrosis mice models
Authors: Yang Zhongshan , Yu Jing-ze , Wen Jing , Ying Yi , Yin Wen , Zhang Si-qi , Pang Wenlin , Wang Cui , Bian Yiao , Yuan Jiali , Yan Jin-yuan
Published: January 2024

Background and Purpose：Pulmonary fibrosis (PF) is the most common type
of chronic lung disease, with a poor prognosis and a high mortality
rate; however, treatment of PF is still a heavy burden. Astragaloside
(AST), a major active component of Astragalus membranaceus, has
demonstrated numerous pharmacological actions in a variety of diseases,
including inflammation and tumors. It is worth noting that AST also
plays an important role in the treatment of fibrotic diseases, but the
mechanisms are still unknown. This study aims to further investigate the
precise mechanisms of anti-fibrosis actin.Experimental Approach：To
assess the anti-fibrosis effect of AST in PF mice, we determined the
level of inflammation and collagen deposition in the lung tissue of PF
mice. And we investigated whether the increased inflammation and
collagen deposition shown in PF mice and human lung fibroblasts (HLF)
cells are mediated by the upregulation of autophagy by inhibiting the
Ras/Raf/MEK/ERK signaling pathway.Key Results: Our initial intriguing
discovery was that AST has a significant therapeutic effect on reducing
collagen deposition and anti-inflammatory effects in PF mice. This
therapeutic effect of ATS could be attributed to autophagy activation.
Additionally, siRNA-mediated autophagy deficiency exacerbates collagen
deposition in HLF. Mechanistically, AST was demonstrated a functional
dephosphorylation of MEK and ERK to inhibit the Ras/Raf/MEK/ERK
signaling pathway, further notice autophagy was activated to varying
degrees by agent depressors of Ras or MEK.Conclusion and Implications:
our findings support the possibility that a therapeutic potential of AST
for PF linking the de-repression mediated Ras/Raf/MEK/ERK signaling
pathway via modulation of autophagy.
Finite control of dielectric constant with magnetic field in Sm-doped Ba-Co U-type hexaferrites
Authors: Malhi Parambir , Kumar Sachin , Singh Mandeep , Singh Anupinder , Sood Ashwani
Published: January 2024

Emergence of memory devices based on magneto-electric coupling leads us to
investigate the dielectric and magneto-dielectric properties of U-type
hexaferrites. (Ba1-3xSm2x)4Co2Fe36O60 ceramics, where x = 0.0-0.25, with the
interval of 0.05, have been produced via auto combustion method and
sintering at 1200?C. Every sample has an R?3m symmetric hexagonal
structure, according to the XRD study. The samples with lower Sm content,
i.e. 0.0 < x < 0.15 have better magnetic properties than the samples having
0.15 < x < 0.25. Impedance spectroscopy has been used to study dielectric
characteristics. The sample with x = 0.15 at 1.2 T and 1000Hz showed maximum
magnetization and a magneto-electric coupling accompanied by a magnetic
coefficient of about 104.9%, which is very high in case of hexaferrites.
Therefore, these results will be fruitful from the application point of
view.
The potential of restorative approaches in domestic violence cases to contribute to more victim-centred responses - based on the experiences of two field-based research programs
Authors: Hera Gabor , Szego Dora
Published: January 2024

The article aims to discuss the opportunities for a restorative approach in
domestic violence (DV) cases based on the results of two empirical research.
After describing the victims? perspective, we introduce the shortcomings of
institutional frontline responses that hinder the effective prevention and
fight against domestic violence. At the end of the paper, some local support
initiatives for victims of DV are described. We examine the aspects of these
initiatives that bring them close to the restorative approach - although
they do not explicitly label themselves as restorative.
Empagliflozin Reduces Liver Fat in Diabetic and Nondiabetic Subjects
Authors: Abdelgani Siham , Khattab Ahmed , Adams John , Baskoy Gozde , Brown Marissa , Clarke Geoff , Larvenenko Olga , A DeFronzo Ralph , Abdul-Ghani Muhammad
Published: January 2024

Objective: To examine the effect of empagliflozin on liver fat content in T2DM and nondiabetic individuals, and the relationship between the decrease in liver fat and other metabolic actions of empagliflozin. Research Design and Methods: 30 T2DM and 27 nondiabetic individuals were randomized to receive in double blind fashion empagliflozin or matching placebo (2:1 ratio) for 12 weeks. Subjects received 75-gram OGTT and measurement of liver fat content with MR spectroscopy before and at study end. Hepatic glucose production before the start of therapy was measured with 3-3H-glucose. Results: Empagliflozin caused 2.39%±0.79 absolute reduction in liver fat content compared to 0.91%±0.64 increase in patients receiving placebo, (p<0.007 with ANOVA). The decrease in liver fat was comparable in both diabetic and nondiabetic individuals (2.75%±0.81 and 1.93%±0.78, respectively, p=ns). The decrease in hepatic fat content caused by empagliflozin was strongly correlated with baseline liver fat content (r =-0.62, p<0.001), decrease in body weight (r=0.53, p<0.001) and improvement in insulin sensitivity (r=-0.51, p<0.001), but was not related to the decrease in fasting plasma glucose or HbA1c or the increase in hepatic glucose production. Conclusion: Empagliflozin is effective in reducing liver fat content in T2DM and in nondiabetic individuals. The decrease in liver fat content is independent of the decrease in plasma glucose concentration and is strongly related to the decrease in body weight and improvement in insulin sensitivity.
Kidney Health Plan 2033 in Korea: bridging the gap between the present and the future
Authors: Kim Do Hyoung , Hyun Young Youl , Cha Jin Joo , Lee Sua , Lee Hyun Kyung , Choi Jong Wook , Kim Su-Hyun , Han Sang Youb , Park Cheol Whee , Lee Eun Young , Cha Dae Ryong , Kim Sung Gyun , Lim Chun Soo , Park Sun-Hee
Published: January 2024

In response to the increase in the prevalence of chronic kidney disease (CKD) in Korea, the growth of patients requiring renal replacement therapy and the subsequent increase in medical costs, the rapid expansion of patients with end-stage kidney disease (ESKD), and the decrease in patients receiving home therapy, including peritoneal dialysis, the Korean Society of Nephrology has proclaimed the new policy, Kidney Health Plan 2033 (KHP 2033). KHP 2033 would serve as a milestone to bridge the current issues to a future solution by directing the prevention and progression of CKD and ESKD, particularly diabetic kidney disease, and increasing the proportion of home therapy, thereby reducing the socioeconomic burden of kidney disease and improving the quality of life. Here, we provide the background for the necessity of KHP 2033, as well as the contents of KHP 2033, and enlighten the Korean Society of Nephrology’s future goals. Together with patients, healthcare providers, academic societies, and national policymakers, we need to move forward with goal-oriented drive and leadership to achieve these goals.
Pentingnya Pemahaman tentang Suhu Ruangan dan Penggunaan Termostat Digital untuk Menghemat Energi
Authors: Suudi Ahmad , Lubis Asnawi , Tantri Novri , Hasymi Zulhendri
Published: January 2024

Artikel pengabdian ini membahas pentingnya pemahaman tentang suhu ruangan dan penggunaan termostat digital untuk menghemat energi. Dalam kondisi di mana energi semakin terbatas dan mahal, meminimalkan penggunaan energi menjadi penting untuk mengurangi biaya dan menjaga lingkungan.

Kegiatan pengabdian ini menyajikan metode praktis untuk menghemat energi dengan mengoptimalkan suhu ruangan melalui kombinasi penggunaan ventilasi tembus, exhaust fan dan termostat digital. Metode yang digunakan adalah ceramah kepada peserta kegiatan yaitu masyarakat dusun Penagan Jaya dilanjutkan dengan diskusi. Tim PKM juga melakukan demontrasi pemasangan ventilasi, exhaust fan dan termostat digital pada ruang kamar salah satu warga.

Setelah dilakukan pengumpulan data hasil pre-test dan post-test dapat disimpulkan terjadi peningkatan pemahaman warga dusun Penagan Jaya peserta pengabdian sebesar 64% dari sebelumnya yang hanya 22% . Pemahaman warga peserta kegiatan berupa pentingnya pemasangan ventilasi udara yang benar dan tepat, serta penggunaan exhaust fan yang dikombinasikan dengan termostat digital sebagai upaya mendapatkan suhu ruangan yang nyaman dengan tetap menghemat energi
Bantuan Teknis Pembuatan Peta Batas Dusun di Dusun Marga Taqwa Desa Natar Kecamatan Natar Kabupaten Lampung Selatan
Authors: Sumanjaya Erlan , Rahmadi Eko , Novianti Tika Christy , Mayasari Rizka
Published: January 2024

Desa Natar merupakan desa dengan luas daerah terbesar sebesar 16,15 km2 terhadap luas kecamatan Lampung Selatan. Dengan luas yang dimiliki, desa Natar juga memiliki 16.143 penduduk dengan persentase pertumbuhan yang cukup tinggi yakni sebesar 8,42% dari tahun 2010. Tingginya persentase pertumbuhan penduduk ini tentunya diiringi dengan pesatnya perkembangan wilayah tersebut, sehingga diperlukan adanya pembaharuan terkait batas wilayah administatif secara berkala. Hal ini senada dengan apabila ditinjau dari aspek spasial kewilayahan masih banyak wilayah desa yang belum memiliki batas yang jelas, dan peta wilayah desa dibuat sesuai kaidah peta yang terstandarisasi. Kondisi ini akan menyebabkan tidak jelasnya luas wilayah desa. Dalam Peraturan Menteri Dalam Negeri Nomor 45 Tahun 2016 tentang Pedoman Penetapan dan Penegasan Batas Desa sudah diatur dengan sangat jelas dan rinci. Oleh karena itu, untuk memenuhi data terbaru mengenai kondisi dusun yang berbasis spasial maka perlu dilakukan pemetaan situasi batas dusun. Berdasarkan kebutuhan yang diperlukan maka kami memberikan bantuan teknis berupa kegiatan  pemetaan batas dusun di Dusun Marga Taqwa, Desa Natar Kabupaten Lampung Selatan Provinsi Lampung. Peta batas desa dibuat dengan melakukan pengukuran dengan menggunakan metode  RTK-NTRIP. Hasil dari pengabdian di dusun Marga Taqwa diperoleh sebanyak 113 koordinat batas dusun dengan total area membentang sebesar 173 Ha.
Edukasi Mitigasi Bencana Banjir di SMAN 1 Metro untuk Mewujudkan Sekolah Siaga Bencana
Authors: Mulyasari Rahmi , Haerudin Nandi , Hesti  , Hidayatika Akroma , Erfani Sandri , Syah Aminudin
Published: January 2024

SMAN 1 Bandar Lampung berlokasi di berlokasi di Jalan AH Nasution 222, Yosodadi, Metro Timur, Lampung. Sekolah ini berada di Kota Metro yang merupakan salah satu daerah rawan banjir, sehingga perlu dilakukan edukasi terkait kebencanaan banjir. Tujuan dari kegiatan pengabdian ini adalah untuk mengedukasi mitra terkait potensi banjir yang ada di daerah pengabdian dan untuk meningkatkan pengetahuan mitra terhadap mitigasi dan manajemen bencana dalam rangka mewujudkan sekolah siaga bencana. Metode yang digunakan dalam pengabdian ini adalah analisis kebutuhan, perancangan, serta pendampingan dan implementasi. Hasil dari kegiatan pengabdian tergambar dari hasil evaluasi dan diskusi yang menunjukkan respon yang positif. Pihak sekolah berharap untuk dilakukannya kegiatan edukasi mitigasi bencana secara berkesinambungan untuk mewujudkan sekolah siaga bencana.
Produksi Kompos dan Eco Enzyme dari Limbah Organik Rumah Tangga di Kelurahan Rajabasa, Bandar Lampung
Authors: Utami Herti , Br Ginting Simparmin , Mulyani Yessi
Published: January 2024

Kegiatan pengabdian ini bertujuan untuk mengedukasi masyarakat tentang pemilahan dan pengelolaan sampah organik menjadi kompos dan eco enzyme. Kegiatan ini dilakukan di Kelurahan Rajabasa, Bandar Lampung dengan mitra adalah Komunitas Sahabat Lingkungan (KSL). Metode yang dilakukan dalam kegiatan pengabdian ini meliputi sosialisasi, pelatihan pembuatan kompos dan eco enzyme dari sampah organik rumah tangga. Dalam sosialisasi dijelaskan secara singkat tentang pemanfaatan dan penanganan sampah, khususnya sampah organik. Pelatihan pembuatan kompos dan eco enzyme diberikan kepada mitra KSL. Permasalahan tentang pengelolaan sampah secara umum dan khususnya yang dihadapi mitra adalah belum memiliki pengetahuan dan peralatan untuk proses pembuatan kompos and eco enzyme. Dengan kegiatan pengabdian Unggulan ini mitra KSL dapat menggunakan peralatan untuk membuat kompos, dan eco enzyme dari limbah organik rumah tangga menjadi produk yang bermanfaat. Kegiatan pengabdian ini telah memberikan keuntungan bagi mitra
BANTUAN TEKNIS PEMBUATAN PETA KONDISI JALAN DUSUN SUKARAME DI DESA NATAR – KABUPATEN LAMPUNG SELATAN
Authors: Suyadi  , Fajriyanto  , Armijon  , Sari Atika
Published: January 2024

Dusun Sukarame merupakan Dusun yang terletak di Desa Natar, Kecamatan Natar Kabupaten Lampung Selatan. Kondisi eksisting jalan di Dusun Sukarame Desa Natar Kecamatan Natar Kabupaten Lampung Selatan tidak seragam, ada yang sudah lapis aspal (Lapen), paving block, onderlagh dan jalan tanah. Tentu hal ini akan membuat kebingungan tersendiri terkait dengan rencana/usulan perbaikan jalan yang dapat diterapkan pada kondisi jalan-jalan tersebut. Sesuai Permendagri No. 114 Tahun 2014 maka Rencana Pembangunan Jangka Menengah Desa (RPJMDesa) dan Rencana Kerja Pembangunan Desa (RKPDesa) merupakan dokumen dasar dalam perencanaan Desa. Dalam rangka mendukung perencanaan tersebut maka salah satu alat untuk mengumpulkan data kondisi dan potensi desa adalah dengan penyusunan peta desa dan kondisi jalan. Peta ini memiliki peranan antara lain, penegasan batas wilayah dusun, potensi perdagangan dan jasa, inventaris aset dusun, membantu perencanaan pembangunan infrastruktur dan dasar informasi pembangunan. Penggabungan pemanfaatan keilmuan Teknik Sipil dan Geodesi dalam hal ini adalah pembuatan peta dan kondisi jalan dengan melakukan survey lapangan seperti pemetaan batas dengan menggunakan GNSS, survey inventory jalan dan marking titik-titik seperti perdagangan jasa di lapangan yang selanjutnya akan di tampilkan dalam bentuk peta dusun.
READING STRATEGIES APPLIED BY BENGKAYANG STUDENTS TO OVERCOME THEIR COMPREHENSION PROBLEMS
Authors: Nelly Ventaria , Setiamunadi Antonina Anggraini
Published: January 2024

Reading is one of the language skills that learners must acquire. However, many students experience difficulties because they lack English knowledge. There are strategies that students can use to overcome their reading difficulties such as translating, asking questions, and using other references. Research about English reading strategies has been conducted in several regions in Indonesia such as in Aceh Besar and Medan, but in Bengkayang, there has never been any research done on that topic. Thus, this study aimed to find out Bengkayang senior high school students’ strategies to overcome their English reading difficulties. The participants of this study were 90 first-grade senior high school students from four senior high schools in Bengkayang. This study uses a quantitative descriptive method by using a questionnaire as its data collecting instrument. The questionnaire contains three open-ended questions and sixteen closed-ended questions. The findings showed that Bengkayang students faced some problems in reading English texts such as lack of vocabulary and grammatical mastery. The strategies to overcome the difficulties are divided into three categories Support, Problem-solving, and Global strategies. Based on the findings, Problem-Solving strategies are the type of strategies that the students often use while comprehending reading texts.
Peran Pemerintah Kabupaten Deli Serdang Dalam Meningkatkan Pembangunan Ekonomi Daerah Melalui Sektor Pariwisata
Authors: Azhari Bintang Akbar , Imsar Imsar
Published: January 2024

This research aims to describe and analyze the role of the Deli Serdang Regency Government in increasing development in the regional economy through the tourism sector (case study on Bali Lestari Beach, Percut Sei Tuan District). This research uses the qualitative methods. And the results of this study, show that in developing or improving regional economic development in the tourism sector, the Deli Serdang Regency Government has carried out its role as an entrepreneur and coordinator to the maximum in order to improve economic development. Although in reality, it is not very perfect there are still obstacles, obstacles but the Government and Movers / members of Pantai Bali Lestari will continue to strive to overcome the problems that will occur.
The Western Reception of Forugh Farrokhzad: New Orientalism and Confessional Poetry
Authors:   Babeș-Bolyai University, Cluj-Napoca, Romania (ra.panait18@gmail.com), Panait Raluca
Published: January 2024

The following study proposes to deconstruct the mythologising of Forugh Farrokhzad (1934/5-1967), a poet known mostly
as Iran’s Sylvia Plath. This kind of analogy is based on interpretative and cultural preconceptions that connect women’s poetry with personal experience and amount the poetic voice to the empirical reality. Beyond that biographical obsession, reified through the export of confessionalism, comparing the two writers also implies appropriation of Forugh Farrokhzad to a Western cultural and literary field. By analysing a few poems, taking a close look at her interviews, and examining the historical context, I shall try to demonstrate that Farrokhzad is actually split between two worlds. Therefore, to associate her with Sylvia Plath can be read as an example of what Fatemeh Keshavarz,
a researcher on Persian literature, calls the New Orientalist narrative.
COACHING ACTIVITY AND ITS PRACTICAL SIGNIFICANCE IN THE PEDAGOGICAL PROCESS
Authors: Dallakyan Armine , Martirosyan Naira , Shakarian Karine
Published: January 2024

The article analyzes the peculiarities of coaching as pedagogical technology. That activity is presented in the context of a coach?s internship. Pedagogical science is the key to the development of modern society, which implies that the education system must be transformed in line with the changes of time. Coaching as a pedagogical technology ensures the learner's personal growth based on planning his own strategy. Therefore, the use of coaching as a pedagogical technology is relevant and in demand in modern schools, as it reveals the maximum potential of all learners and helps them develop cognitive-metacognitive abilities. The coach creates conditions for self-development by guiding the learners' educational needs, goals and potential opportunities.
Creando redes de aprendizaje: Una experiencia intergeneracional en educación primaria
Authors: Eiguren Munitis Amaia , Berasategi Sancho Naiara , Correa Gorospe José Miguel
Published: January 2024

La sociedad actual se encuentra inmersa en unanimidad de cambios desconocidos hasta la fecha. Entre ellos se encuentran la longevidad y movilidad de las personas. Es decir, nos encontramos ante sociedades con mayor población mayor y con mayor diversidad cultural. Dentro de este contexto la escuela se muestra como un entorno inmejorable para fomentar la cohesión social e intercultural para crear redes de aprendizaje más allá del contenido curricular. En el presente artículo se presente la evaluación de una experiencia intergeneracional basada en el apoyo lector llevada a cabo con alumnado de educación primaria. Partiendo de una metodología cualitativa, por un lado, se han analizado dibujos y fotografías relacionadas con la experiencia y por otro lado se han llevado a cabo cinco grupos de discusión. Los resultados subrayan la potencialidad de la metodología utilizada a la hora de enriquecer el curriculum.  Asimismo, destaca el impacto que tienen este tipo de experiencias a nivel individual, comunitario, escolar y social fomentando la interculturalidad y el aprendizaje a lo largo de la vida.
„Magazyn Muzyczny” na mapie polskiej prasy rockowej (analiza strukturalno- -komparatystyczna)
Authors: Trudzik Artur Mariusz
Published: January 2024

„Magazyn Muzyczny” był jednym z dwóch najbardziej opiniotwórczych (obok „Non Stopu”), można rzec — kultowych czasopism okresu PRL-u, lansujących muzykę popularną, zwłaszcza rock. Oba przechodziły podobną ewolucję, choć pierwszy z nich miał dużo dłuższą historię, ponieważ był bezpośrednim następcą najstarszego w Europie Środkowo-Wschodniej perio-dyku poświęconego muzyce rozrywkowej, tj. „Jazzu”, powstałego w 1956 r., jednak od lat 80. wraz ze zmianami redakcyjnymi, wewnętrznymi, strukturalny-mi, ale przede wszystkim reorientacją gustów muzycz-nych Polaków, głównie młodzieży, związaną z boomem rocka, stał się w zasadzie (w ostatnich latach) odrębnym, nowym periodykiem. Jego analiza ilościowa (strukturalna) wypełniła treść tego artykułu, ale stanowi ona również podstawę szerszych badań nad miesięcz-nikiem, które powinny przyjąć postać dwutomowej monografii.
Structural and Mechanical Properties of Orthorhombic Libeh3: AB-Initio Study
Authors: Rahrah M. , Lebga N. , Latreche A. , Daoud S. , Benmakhlouf A.
Published: January 2024

The structural parameters and the elastic properties of orthorhombic LiBeH3 material were predicted theoretically using the density functional theory (DFT). The exchange-correlation potential term was treated using the local density approximation (LDA). Our values of the structural parameters and elastic constants predicted for LiBeH3 material agree well with other results of the literature.

The bulk modulus calculated from the BFGS technique is comparable with the value obtained from the elastic constants. The universal anisotropy factor, Young's and shear moduli, Poisson's ratio, Pugh’s ratio, Lame’s coefficients and the microhardness were also determined for an ideal polycrystalline LiBeH3 material. Based on the results of Poisson's ratio and Pugh’s ratio obtained in this work, this hydride material would be classified as a brittle material in nature.

We estimate also the elastic wave velocities, the Debye temperature and the acoustic impedance of the polycrystalline material. Our predicted values obtained from the local density approximation for LiBeH3 material agreed well with the data of the literature obtained from the generalized gradient approximation (GGA).
How to treat cardiac dyssynchrony in heart failure with reduced ejection fraction
Authors: Bogdan Stefan , Ababei Alexandru , Glikson Michael
Published: January 2024

Cardiac resynchronization therapy (CRT) has become part of the standard of care for symptomatic patients with heart failure, reduced ejection fraction (HRrEF), and wide QRS, despite optimal medical therapy. Device technology, operator experience, and post-implant optimization on follow-up have significantly improved CRT response during the last decade. In parallel, conduction system pacing (CSP) has emerged as a new and potentially better tool for maintaining physiological ventricular activation in patients with antibradycardia pacing, as well as an alternative for dyssynchrony correction in HFrEF patients. The current review focuses on cardiac dyssynchrony pathophysiology and correction methods, clinical evidence on CRT and CSP as therapies for cardiac dyssynchrony, and the role of each according to clinical evidence and current guidelines for HFrEF treatment.
Clinical phenotypes of patients with acute stroke: a secondary analysis
Authors: Hajiesmaeili Mohammadreza , Nooraei Navid , Alamdari Nasser Malekpour , Bidgoli Behruz Farzanegan , Jame Sanaz Zargar Balaye , Moghaddam Nader Markazi , Fathi Mohammad
Published: January 2024

Introduction

Stroke is a leading cause of mortality worldwide and a major cause of disability having a high burden on patients, society, and caregiving systems. This study was conducted to investigate the presence of clusters of in-hospital patients with acute stroke based on demographic and clinical data. Cluster analysis reveals patterns in patient characteristics without requiring knowledge of a predefined patient category or assumptions about likely groupings within the data.

Methods

We performed a secondary analysis of open-access anonymized data from patients with acute stroke admitted to a hospital between December 2019 to June 2021. In total, 216 patients (78; 36.1% men) were included in the analytical dataset with a mean (SD) age of 60.3 (14.4). Many demographic and clinical features were included in the analysis and the Barthel Index on discharge was used for comparing the functional recovery of the identified clusters.

Results

Hierarchical clustering based on the principal components identified two clusters of 109 and 107 patients. The clusters were different in the Barthel Index scores on discharge with the mean (SD) of 39.3 (29.3) versus 62.6 (29.4); t (213.87) = −5.818, P <0.001, Cohen’s d (95%CI) = −0.80 (−1.07, −0.52). A logistic model showed that age, systolic blood pressure, pulse rate, D-dimer blood level, low-density lipoprotein, hemoglobin, creatinine concentration, the National Institute of Health Stroke Scale value, and the Barthel Index scores on admission were significant predictors of cluster profiles (all P ≤0.029).

Conclusion

There are two clusters in hospitalized patients with acute stroke with significantly different functional recovery. This allows prognostic grouping of hospitalized acute stroke patients for prioritization of care or resource allocation. The clusters can be recognized using easily measured demographic and clinical features.
Correlation between Clinical Features and Laboratory Parameters and Outcome in Acute Copper Sulphate Poisoning: A Cross-Sectional Observational Study
Authors:   Jashore Medical College Hospital
Published: January 2024

Ingestion of copper sulphate is a common mode of poisoning in the Indian subcontinent. Cases are mainly suicidal in nature. The clinical course of the copper sulphate intoxicated patient is often complex involving intravascular hemolysis, jaundice and renal failure. The treatment is mainly supportive. Mortality is quite high in severe cases if treatment is not adequate and prompt.
A Free Speech-Based Response to Media Polarization
Authors: Wright R. George
Published: January 2024

The degree of polarization, distrust, and animosity in the political elements of our social media have reached remarkable levels. But any attempt to address the relevant problems that requires legal enforcement inevitably raises serious issues of free speech and free press. Relying instead on fact checkers has its own numerous, substantial, and inevitable limitations, some of which parallel the very problems sought to be addressed. More promising are political social media reforms, akin to that proposed herein, that are voluntary, generally pluralistic and critical, reflective of the relevant social science evidence, and unlikely to raise problems of free speech and freedom of the press.
Pola Abnormal Return Saham Sektor Pertanian Dalam Indeks IDNONCYC Pada Peristiwa Kenaikan Harga Bahan Bakar Minyak 3 September 2022
Authors: Haikal Muhammad , Esperanza Dhany , Wiyono Sulistyodewi Nur , Pardian Pandi
Published: January 2024

The increase in fuel prices announced on September 3, 2022, has the potential to create impacts on the economy, such as inflation, rising production factor costs, and income effects, which, in turn, affect the returns that investors will receive. This research was conducted with the aim of understanding the influence of the fuel price increase on September 3, 2022, on the movement of stock prices in the primary industry sector index (IDXNONCYC) and to determine the return patterns in the primary industry sector (IDXNONCYC). The sample used in this study was purposively selected from sub-industries relevant to the components of the agribusiness subsystem, resulting in 25 samples from the Retail & Food Distribution, Supermarket, Processed Milk, Processed Food, Meat Processing, Plantation, and Tobacco sub-industries, and was analyzed over a 21-day observation period. The analysis process using descriptive statistics shows the distribution of actual returns with 36% positive, 41% negative, and 23% zero actual returns. Additionally, a positive abnormal return pattern was found, accounting for 40% with a total of 209 occurrences, and a negative abnormal return pattern accounted for 60% with a total of 316 occurrences. Furthermore, a consecutive negative abnormal return pattern was identified for 17 days, and a varied positive abnormal return pattern was also observed.
Strategi Pengembangan Sumber Daya Manusia Pada Usaha Sayuran Hidroponik Di CV Hidroponikita Tani Mandiri Kota Depok Jawa Barat
Authors: Ali Sultan Zein
Published: January 2024

CV Hidroponikita Tani Mandiri is one of the companies that produce vegetables through hydroponic cultivation. The cultivated vegetables include green spinach and red spinach. This research aims to provide appropriate recommendations for human resource development strategies for the company. The research method used is qualitative, supported by quantitative data. Primary data collection is obtained directly through interviews and questionnaires, while secondary data is gathered through relevant journal literature, theses, and data from the Central Statistics Bureau (BPS). The sampling technique used is purposive sampling, intentionally selecting 11 individuals as samples. The data analysis in this research is conducted using SWOT analysis. The results of this study indicate that CV Hidroponikita Tani Mandiri is positioned in quadrant 1, which is a positive position as it has the strength to overcome weaknesses and possesses opportunities to minimize threats. There are 8 strategic formulations applied for human resource development in CV Hidroponikita Tani Mandiri based on the SWOT analysis.
Efisiensi Pemanfaatan Berbagai Faktor Produksi pada Peternakan Itik Rakyat (Survey di Kabupaten Indramayu)
Authors: Herlina Linda , Fitriani Anita
Published: January 2024

The duck farming industry exhibits potential for expansion, offering possibilities for increased income from its operations. In November 2021, a study was conducted in Indramayu Regency to assess the technical, allocative, and economic efficiency levels in utilizing production factors within duck farming enterprises. Employing a survey method, 100 breeders served as observation units, and variables such as the quantity of products (Y), seeds (X1), feed (X2), cages (X3), and labor (X4) were examined. The analysis employed the Cobb-Douglas function model. Results revealed inefficiencies in the utilization of production factors in the region. Technical efficiency in the livestock sector registered a value of 1.282 (seeds = 0.642; feed = 0.310; cages = 0.162; labor = 0.168). Price efficiency stood at 6.891 (seeds = 4.149; feed = 1.523; cages = 0.876; labor = 0.343), while economic efficiency reached 3.351 (seeds = 2.664; feed = 0.487; cage = 0.142; labor = 0.058). The duck farming endeavors in the studied area have not yet attained optimal efficiency levels, indicating a situation of increasing returns to scale.
Perspectivas das abordagens nutricionais no transtorno do espectro autista
Authors: Costa Madson Matheus Garcia , Solano Ariel Christine dos Anjos , Silva Flavia Dhullyane Souza , Silva Flaviane Silva da , Silva Rosalba Velasco Guimarães , Siqueira Camila Tenorio , Amaral Vanessa Carolina Costa , Noce Rosilene Reis Della , Silva Luísa Margareth Carneiro da
Published: January 2024

Objetivo: Descrever as terapias alimentares e os principais impactos no tratamento do Transtorno do Espectro Autista (TEA). Métodos: Trata-se de uma revisão integrativa, com levantamento bibliográfico realizado em janeiro de 2013 a julho de 2023 nas bases de dados: Biblioteca Virtual em Saúde (BVS) e Scientific Electronic Library Online (SciELO), por meio dos descritores em Ciências da Saúde (DeCS) Autismo, Terapia Nutricional e Alimentação, com o uso do operador booleano “And”. Foram incluídos artigos publicados na língua portuguesa, inglesa e espanhola, com textos completos disponíveis, e publicados entre os dez anos respectivos. Resultados: No total, 12 estudos estavam de acordo com os critérios de inclusão estabelecidos, sendo possível descrever o impacto das terapias alimentares em crianças com TEA e diversas metodologias e estratégias trabalhadas para a evolução de forma significativa no desenvolvimento destes pacientes por meio do processo das terapias alimentares. Considerações finais: As terapias alimentares, mesmo demonstrando diversos impactos e resultados positivos no tratamento do Transtorno do Espectro Autista, é notável que há necessidade de mais estudos para a melhora na eficácia das estratégias nutricionais trabalhadas e desenvolvimento de novas, visando a qualidade de vida destes indivíduos e de suas famílias.
Experimental Study and Turbulence Dissipative Scale Modelling of the Rapid Micromixing of Impinging, Paper-Thin Sheets of Liquids
Authors: Demyanovich Robert
Published: January 2024

Previous studies have shown that the impingement of thin liquid sheets produces high energy dissipation rates due to the release of kinetic energy in a very small volume of liquid (0.0001 to 0.01 g), even though flowrates are on the order of L/min. Rapid micromixing occurs because the dissipated energy leads to a substantial reduction in the initial segregation size scale of the liquids, which is the single-sheet thickness at impingement (~ 100 μm). In the present study, the micromixing was investigated by following the progress of an acid-base neutralization accompanied by a change in fluorescence intensity of a fluorophore. Micromixing was modeled using a framework that assumes diffusion and reaction of species occur within slabs of fixed thickness (2L). The slabs are fixed in size because the released kinetic energy is dissipated within one turnover time of the large energy-containing eddies produced in the turbulent impingement zone. A simulation, which included a module for calculating the fluorescence intensity, determined 2L for experimental energy dissipation rates ranging from 40,000 to 7,700,000 W/kg. 2L was found to lie in the range of turbulent dissipative scales less than the Taylor microscale but greater than the Kolmogorov microscale. 2L is a function of the energy dissipation rate, kinematic viscosity, large-eddy Reynolds number and fluctuating turbulent velocity. For some correlations, 2L follows the same relationship as the Taylor microscale, but for others, the relationship is analogous to the Kolmogorov microscale.
Raney Nickel-Catalyzed Deuterium Labeling of Nitrogen-Containing Heterocycles and Pharmaceuticals under Continuous Flow Conditions
Authors: Minya Ferenc , Mészáros Ádám , Csizmadia Eszter , Suskó Dávid , Raji Mounir , Sipos Gellért
Published: January 2024

Deuterium-labeled compounds play a pivotal role in physical organic chemistry, life sciences, and materials science. This has resulted in a surge of interest in deuterium-labeled active pharmaceutical ingredients in recent years. In this study, we present a continuous flow Raney nickel-catalyzed hydrogen isotope exchange process that boasts compatibility with a wide spectrum of nitrogen-containing heterocycles and pharmaceutical compounds. The broad applicability of the developed method was demonstrated through successful labeling of various purine bases, imidazoles, pyridines, and active pharmaceutical ingredients, including complex structures like abacavir and remdesivir. Control experiments revealed Raney nickel's crucial role in the exchange process, showcasing the superiority of the continuous flow approach over batch reactions. Furthermore, a scaled-up experiment demonstrated the robustness of the catalyst.
Los derechos reales en el mundo moderno
Authors: Guardiola Juan José
Published: January 2024

Las enormes transformaciones en todos los ámbitos, operadas en las últimas décadas por diversos factores, pero especialmente por los avances tecnológicos, a un ritmo cada vez más acelerado y favorecido por la pandemia del COVID-19, han provocado que las diferentes ramas del derecho se preocupen en dar solución a los nuevos problemas que se suscitan. Esto es evidente en materia de derecho público, laboral, contractual, familiar, de la personalidad e intelectual. También, aunque en forma menos palpable y pese a la rigidez evolutiva de los derechos reales, esta realidad —física y virtual— del mundo moderno repercute en el área de su competencia y debe encarar los desafíos que plantea. El trabajo aborda algunas de esas situaciones, sus potenciales conflictos y las respuestas a su alcance, a partir de la relación directa e inmediata que les es propia, la mayor amplitud de su objeto y del concepto de propiedad, y la protección que merecen.
Mi smartphone y yo. Las motivaciones para usarlo entre jóvenes chilenos. Un estudio a través del tiempo
Authors: Leiva Soto Ricardo Alberto , Benavides Almarza Cristóbal Fernando , Riveros Martínez Alejandra
Published: January 2024

El objetivo de nuestra investigación es medir cómo los usos y motivaciones para usar teléfonos inteligentes por parte de la joven población chilena han cambiado a través del tiempo y cómo estas motivaciones para comprometerse con los teléfonos inteligentes afectan el tiempo dedicado a enviar mensajes de texto en estos dispositivos portátiles.
Replicamos una encuesta cara a cara entre millennials y centennials chilenos, realizada por primera vez en 2009 (n= 1.320), repetida en 2015 (n= 744) y realizada nuevamente en 2021 (n= 846). Esta última ola se realizó entre julio y noviembre a sujetos de entre 18 y 25 años residentes en Chile.
El cuestionario incluyó 44 preguntas basadas en escalas previamente validadas en estudios que relacionan la Teoría de Usos y Gratificaciones con los teléfonos móviles, actitudes hacia la tecnología y evaluaciones de los usuarios sobre los atributos de los teléfonos móviles definidas por Albarran (2009). También se incluyeron variables relacionadas con datos demográficos (por ejemplo, zona de residencia) y de género, que los encuestados declararon.
La mayoría de las motivaciones para utilizar teléfonos inteligentes medidas en nuestra encuesta de 2021 fueron las mismas que medimos en 2015 y 2009, pero otras son nuevas. Para medir cómo ha cambiado el atractivo de las motivaciones a lo largo del tiempo, realizamos una comparación de medias. También realizamos un análisis factorial exploratorio para agregar motivaciones y análisis de regresión para cuantificar cómo las motivaciones afectaban el tiempo que los jóvenes dedicaban a enviar mensajes de texto.