bluuebunny/crossref_metadata_2025 huggingface dataset:
Anthropocentricity as a Principle of Translation: Faust by K. A. Ivanov
Authors:   Novosibirsk State University of Economics and Management, Galina M. Vasilyeva
Published: November 2021

The tragedy’s translation is studied as a result of more than 38 years of work by the last gymnasium headmaster in Tsarskoye Selo, the man of “Faust’s culture”. The relevance of the research is determined by the fact that each translation of a tragedy allows one to grasp into new cultural meanings and influences poetic practices and translator’s representation, as well as understanding of Christianity. The problem of the research is to identify the multifunctional concept of “anthropocentricity” on specifics of Ivanov’s translation in cultural-historical, confessional and linguistic aspects. The translation was published in 2006, but there isn’t any research on it in the academic field yet. The essence of the scientific hypothesis is that the principle of Ivanov’s translation is anthropocentricity. Ivanov avoided dogmatic dependence on the terminological system and believed that the term was losing its metaphorical energy. He gave no nomination for the concept, explaining it in an empirical sense. According to Ivanov, it is real events that are the basis for interpretations and conclusions. Comprehension of one’s own experience is an unconditional characteristic of anthropocentrism. The translator also offered a kind of retrospective exhibition, recalled like-minded people, amateurs and connoisseurs of Goethe. They encoded values that are connected in the mind of the translator with the name of Goethe and his characters. The unity of anthroponyms acquiring cultural meanings forms Ivanov’s anthropocentric code. In this article, an integrative interdisciplinary method is used, which has an epistemological capacity. The author of the article came to the following conclusions. Ivanov did not raise the issue of expedience of establishing several translations for one poetical work. A good translation is possible only in the context of a great literary tradition, the predecessors’ experience. Poetic “inner men” complement each other by the rules of palimpsest. The fold participates in the poetic events, such as: the image’s creation, the selection of intonations, that determined the uniqueness and autobiographical subtext of the translation. The translation of the Ivanov’s tragedy is perceived as a manifestation of educational intentions. Ivanov assumed that there is a natural pedagogy of the classical example in Goethe’s work and included this in his project of public education. The translation carries obvious time features: the prewar and revolutionary eras. External chaotic life events were contrasted with internal regeneration of the previous cultural discipline. Ivanov was looking for analogues of the work, such as style, themes in Russian literature.
‹Da habe ich es dann einfach ausgeschaltet›
Authors: Viertel Michael , Krieter Philipp , Breiter Andreas
Published: November 2021

Durch die Datafizierung im Bildungsbereich eröffnen sich neue Möglichkeiten datengetriebene Analysen von Lernprozessen voranzutreiben. Das Dilemma, einerseits Lernprozesse verbessern zu können und andererseits immer stärker in die Privatsphäre der Lernenden einzudringen, lässt sich hierbei nicht vollständig auflösen. In diesem Beitrag möchten wir vorstellen, wie im Projekt musicalytics in Musikschulkursen zum Thema Songwriting in hybriden Lehr-/Lernarrangements während des gesamten Kursverlaufs Bildschirmaufzeichnungen angefertigt wurden, um die Software- und Internetnutzung durch die Teilnehmenden ausserhalb ihrer regulären Kurszeiten zu untersuchen. Neben einer Darstellung der technischen Umsetzung dieser hoch immersiven Form der Datensammlung werden im Beitrag vor allem die Implikationen einer solchen Datafizierung am Beispiel von Bildschirmaufnahmen für die Teilnehmenden diskutiert. Die Lernenden wurden im Anschluss an die Kurse befragt, wie sie diese weitgehende Form der Datenerhebung wahrgenommen haben und welche Rolle diese Art der Beobachtung für ihre Kursaktivitäten spielte. Die zentralen Ergebnisse der qualitativen Interviewstudie mit 15 Teilnehmenden geben Einblick in die ambivalenten Positionierungen der Befragten hinsichtlich Selbstbestimmung, Entgrenzung, Vermessung und Kontrolle im Kursverlauf. Die Ergebnisse werden vor dem Hintergrund des non-formalen Lernsettings eingeordnet und diskutiert. Zudem wird deren mögliche Bedeutung für formale Bildungskontexte wie die Schule kritisch reflektiert.
Zur (ambivalenten) Wirkmächtigkeit datengetriebener Lernplattformen
Authors: Förschler Annina , Hartong Sigrid , Kramer Anouschka , Meister-Scheytt Claudia , Junne Jaromir
Published: November 2021

Mit einer Nutzung in über 85% der Grundschulen zählt Antolin zu den in Deutschland beliebtesten digitalen Lernplattformen zur Förderung von Lesekompetenz. Auch weil Antolin hierbei in zunehmendem Masse direkt in schulweite digitale Infrastrukturen (Schulinformationssysteme) integriert wird, kann es als wirkmächtiges Element der wachsenden «Datengetriebenheit» von Schule verstanden werden, wurde aber bislang kaum als solches kritisch reflektiert. Diese Forschungslücke möchte der vorliegende Beitrag schliessen, indem er die Plattform als Erzeugung einer designbasierten, datafizierten und datafizierenden Form digitaler Bildungswelt in den Blick nimmt. Während die Plattform dabei einerseits erst aus dem vermittelten Zusammenspiel unterschiedlichster Praktiken (von Buchverlagen, Lehrpersonen, Schülerinnen und Schülern etc.) hervorgebracht wird, so erzeugt sie andererseits ein relationales, von Daten und Algorithmen geprägtes Gesamtgefüge, welches die genannten Praktiken auf spezifische Weise (un-)sichtbar, (un-)bedeutsam, (un-)möglich und unterschiedlich wertvoll macht. Gleichwohl wird Antolin je nach Kontext sehr unterschiedlich adaptiert, justiert und an bestehende Praktiken angeschlossen, sodass sich hier wiederum eine Vielzahl möglicher «Wirkungen» entfalten. Insgesamt, so soll dieser Beitrag zeigen, ist es dieses spezifische Zusammenspiel von Regulierung und kontinuierlicher Kontextualisierung, welches in Zukunft sowohl konzeptuell-methodisch als auch empirisch besser greifbar gemacht werden muss, um eine kritisch-bewusste Einschätzung und Gestaltung digitaler Lern- bzw. Datenplattformen als Kernmechanismus zunehmend «datengetriebener» Schule zu ermöglichen.
Auf dem Weg zu digital souverän agierenden Schulen
Authors: Rau Franco , Geritan Anna
Published: November 2021

Ziel des Beitrages ist, das Konzept und erste Erkenntnisse eines entwicklungsorientierten Forschungsprojektes zur Begleitung von Modellschulen auf ihrem Weg hin zu digital souverän agierenden Schulen zu präsentieren. In der Betrachtung von zwei ausgewählten Problem- und Handlungsfeldern wird empirisch fundiert beschrieben, mit welchen Herausforderungen digital weniger fortgeschrittene Schulen im Kontext aktueller Digitalisierungsdiskurse unter Pandemiebedingungen konfrontiert sind und wie die Gestaltung von Schulentwicklungsprozessen in der konkreten schulischen Praxis unterstützt werden kann. Das erste Problemfeld widmet sich der Frage, wie ausgehend von einem technisch vorhandenen Tablet-Klassensatz Lehrpersonen für mobiles Lernen zur Sprachförderung sensibilisiert werden können. Das zweite Problemfeld skizziert Herausforderungen und Ansätze zur Etablierung digitaler Lernplattformen an einer integrierten Gesamtschule. Die Projekterfahrungen dokumentieren Möglichkeiten zur Erschliessung neuer Handlungsspielräume und schulpraktische Bedingungen, die als einschränkend erlebt werden. Begrenzte Handlungsmöglichkeiten der Schulen wurden insbesondere bei Prozessen der Datenverarbeitung sowie Fragen des Datenschutzes sichtbar.
Seaborne chemical trade prospects
Authors: R. Boşneagu
Published: November 2021

The number of chemical products transported by sea is very high. They have different physical and chemical properties, and thus come together in very different ways when they are released into the water. In response, the environmental modeling impact is difficult, and consequently, the co-operation and preparation for potential accidents are particularly essential. The high demand for chemical substances due to a high volume of transport, which is worldwide continually growing. The chemical products transport is different from the oils and petroleum products transport and requires special vessels, specialized equipment, and complicated handling, but also the specialized training of the company, both theoretically and practically. Those involved need to understand the nature of the different substances and to be aware of the possible perils involved in their manipulation. Maritime transport of goods implies enormous costs and requires significant investments. Therefore, governments impose stricter regulations and restrictions on environmental protection. It is expected that such regulations will restrict the market in the long run. It is also expected that geopolitical issues and political instability will limit the offer for chemical products transport.
DDoS detection and prevention based on artificial intelligence techniques
Authors: D. Glăvan
Published: November 2021

Distributed Denial of Service (DDoS) attacks have been the major threats for the Internet and can bring great loss to companies and governments. With the development of emerging technologies, such as cloud computing, Internet of Things (IoT), artificial intelligence techniques, attackers can launch a huge volume of DDoS attacks with a lower cost, and it is much harder to detect and prevent DDoS attacks, because DDoS traffic is similar to normal traffic. Some artificial intelligence techniques like machine learning algorithms have been used to classify DDoS attack traffic and detect DDoS attacks, such as Naive Bayes and Random forest tree. In the paper, we survey on the latest progress on the DDoS attack detection using artificial intelligence techniques and give recommendations on artificial intelligence techniques to be used in DDoS attack detection and prevention.
Experimental calibration of an Fe3+/Fe2+-in-amphibole oxybarometer and its application to shallow magmatic processes at Shiveluch Volcano, Kamchatka
Authors: Goltz Andrea E. , Krawczynski Michael J. , McCanta Molly C. , Dyar M. Darby
Published: November 2021

Oxygen fugacity is an important but difficult parameter to constrain for primitive arc magmas. In this study, the partitioning behavior of Fe3+/Fe2+ between amphibole and glass synthesized in piston-cylinder and cold-seal apparatus experiments is developed as an oxybarometer, applicable to magmas ranging from basaltic to dacitic composition. The partitioning of Fe2+ is strongly dependent on melt polymerization; the relative compatibility of Fe2+ in amphibole decreases with increasing polymerization. The Fe2+/Mg distribution coefficient between amphibole and melt is a relatively constant value across all compositions and is, on average, 0.27. The amphibole oxybarometer is applied to amphibole in mafic enclaves, cumulates, and basaltic tephra erupted from Shiveluch volcano in Kamchatka with measured Fe3+/FeTotal. An average Fe3+/Fe2+ amphibole-glass distribution coefficient for basalt is used to convert the Fe3+/FeTotal of amphibole in samples from Shiveluch to magmatic oxygen fugacity relative to NNO. The fO2 of primitive melts at the volcano is approximately NNO+2 and is faithfully recorded in amphibole from an amphibole-rich cumulate and the basaltic tephra. Apparently, higher fO2 recorded by amphibole in mafic enclaves likely results from partial dehydrogenation of amphibole during residence in a shallow andesite storage region. We identify three pulses of mafic magma recharge within two weeks of, a month before, and two to three months before the eruption and find that, at each of these times, the host andesite was recharged by at least two magmas at varying stages of differentiation. Application of the amphibole oxybarometer not only gives insight into magmatic fO2 but also potentially details of shallow magmatic processes.
The role of graphite in the formation of unconformity-related uranium deposits of the Athabasca Basin, Canada: A case study of Raman spectroscopy of graphite from the world-class Phoenix uranium deposit
Authors: Song Hao , Chi Guoxiang , Wang Kewen , Li Zenghua , Bethune Kathryn M. , Potter Eric G. , Liu Yongxing
Published: November 2021

The unconformity-related uranium (URU) deposits in the Proterozoic Athabasca Basin (Canada) represent the richest, and one of the most important, uranium endowments in the world. Most of the URU deposits are associated with pre-existing graphitic basement faults that were reactivated after the formation of the basin. These graphite-rich structures have been widely used as a vector for exploration, but the nature of the association of the URU deposits with graphitic basement faults has been debated for over four decades. Proposed roles of graphite include: (1) as a direct reducing agent to reduce U6+ to U4+ and precipitate uraninite; (2) as a precursor of hydrocarbons (mainly CH4) produced in situ or nearby and then used as a reducing agent for uraninite precipitation; (3) as a precursor of hydrocarbons produced at depth that were remobilized to the site of mineralization and acted as a reducing agent for uraninite precipitation; and (4) as a lubricant facilitating faulting and fluid flow that led to uranium mineralization. This paper uses the Phoenix uranium deposit in the southeastern Athabasca Basin as a case study to address these uncertainties. Petrographic studies indicate that there is no direct contact between graphite and uraninite at microscopic scales, and the content of graphite in the graphitic metapelite along the ore-controlling WS Shear Zone does not show a systematic change with the distance from the unconformity surface. Raman spectroscopic studies of graphite suggest that the degree of structural disorder of graphite, expressed by various parameters related to the D bands and G band ratios, does not change systematically with the distance from the unconformity surface either. The minor irregularities in these parameters near the unconformity are better explained by paleo-weathering related to the unconformity and/or diagenetic processes than by hydrothermal activity related to uranium mineralization. Based on these observations and interpretations, the role of graphite as an in situ reducing agent, either directly or as a provider of hydrocarbons, is discounted. It is proposed that hydrocarbons derived from graphite at depth, tapped by episodic reactivation or seismicity of the basement faults that was facilitated by graphite as a lubricant, were responsible for URU mineralization.
RESULTATS DE LA CHIRURGIE DES TUMEURS DE LOREILLETTE DROITE SURGICAL RESULTS OF RIGHT ATRIAL TUMORS
Authors:   Service De Chirurgie Cardiovasculaire, Hopital Militaire dInstruction Mohammed V, Universite Sidi Mohamed Ben Abdellah, Fes, Maroc., Atmani Noureddine , Seghrouchni Aniss ,   Service De Chirurgie Cardiovasculaire, Hopital Militaire dInstruction Mohammed V, Universite Sidi Mohamed Ben Abdellah, Fes, Maroc., Moutakiallah Younes ,   Service de Chirurgie Cardiovasculaire, Hopital Militaire dInstruction Mohammed V, Universite Mohammed V Souissi- Rabat, Maroc., Elbekkali Youssef ,   Service de Chirurgie Cardiovasculaire, Hopital Militaire dInstruction Mohammed V, Universite Mohammed V Souissi- Rabat, Maroc.
Published: November 2021

Introduction : Les tumeurs primitives de loreillette droite sont rares et leur interet tient aux reelles possibilites chirurgicales pour certaines dentre elles, alors que les tumeurs secondaires ou metastases sont un peu plus frequentes et leur origine est dominee par lextension tumorale locoregionale ou a distance. Patients Et Methodes : Il sagit dune etude retrospective portant sur une serie de 7 patients operes entre 2000 et 2014 dans le service de chirurgie cardio-vasculaire de lhopital militaire Mohammed V. Lage moyen est de 38 ans. Il sagit de 5 cas de tumeurs primitives : 4 cas de tumeurs benignes (myxome) et une tumeur maligne (angiosarcome) et deus cas de tumeurs secondaires (extension de cancer renal). Resultats : Lexerese chirurgicale a ete realisee sous circulation extracorporelle par sternotomie pour les tumeurs primitives et par sterno-laparotomie pour les tumeurs secondaires. Les suites operatoires immediates etaient simples avec une mortalite hospitaliere nulle. Le pronostic est excellent pour le myxome, effroyable pour langiosacome, alors que celui des tumeurs par extension reste tributaire du cancer initial. Conclusion :Les tumeurs de loreillette droits sont rares, dont le diagnostic a largement beneficie de limagerie moderne qui permet la presomption diagnostic et de proposer une prise en charge chirurgicale adaptee.
PAEDERIA FOETIDA: INDIGENOUS MEDICINAL PLANTS OF NORTHEAST INDIA
Authors:   Faculty of Pharmaceutical Science, Assam Downtown University, Panikhaiti, Guwahati, Assam., Papi Dakme , Kumar Dey Biplab ,   Faculty of Pharmaceutical Science, Assam Downtown University, Panikhaiti, Guwahati, Assam., Saha Suman ,   Faculty of Pharmaceutical Science, Assam Downtown University, Panikhaiti, Guwahati, Assam., Choudhury Ananta ,   Faculty of Pharmaceutical Science, Assam Downtown University, Panikhaiti, Guwahati, Assam.
Published: November 2021

The plant Paederia foetida has customarily been utilized for restorative purposes, however, its system of helpful impacts has remained generally obscure. The northeastern locale of India comprises one of the biodiversity focal points of the world. The ethnic gatherings occupying this locale practice their particular customary information frameworks utilizing biodiversity for food and medical care. Among the less-concentrated plants, Paederia foetida has been utilized by different ethnic clans as food and medication. Many of its ethnobotanical properties relate to the hepatoprotective and gastrointestinal. This is a review of the ethnobotanical uses, phytochemistry, and therapeutic properties of Paederia foetida compiled from various reports. Paederia foetida is promising as a solution for the way of life- related conditions, particularly the treatment of liver cirrhosis. Its utility highlights the need for the evaluation of tribal plants as medicines and the species that could be considered for the development of new drugs.
ASSESSMENT OF BONE REGENERATION AFTER PLACEMENT OF IMMEDIATE IMPLANTS USING STICKY BONE AND CGF MEMBRANE
Authors: Prabhusankar K. , Muthukumaran P. , Usha V. , Muthuraman Varun , Rajabackiyam G. , Christo Aravind
Published: November 2021

Aim: Assessment Of Bone Regeneration After Placement Of Immediate Implants Using Sticky Bone And CGF Membrane. Materials And Methods: The study was performed in a series of 10 patients aged 25- 40 years with hopeless prognosis of tooth and needing immediate implant replacement. After placement of implants, the sites were augmented with sticky bone and CGF membrane. The bone regeneration was assessed radiologicaly in 3, 6 and 12 months. The results were recorded. Results: There was statistical significance comparative with intraoperative and 3,6,12 months postoperative was (p=0.001),(p=0.002),(p=0.004) suggesting there was significant difference there. Conclusion: It was concluded thatImmediate implant placement along with sticky bone grafting provides good implant success with bone regeneration surrounding the implant.
Productivity of sweet sorghum (Sorghum saccharatum L.) depending on the elements of plant сultivation technology for biofuel in the zone of insufficient moisture in the Forest-Steppe of Ukraine
Authors: Hanzhenko O. M.
Published: November 2021

Purpose. To reveal the influence of harvest timing of biomass of sweet sorghum various varieties and hybrids on their productivity and biofuel yield in the zone of insufficient moisture in the Eastern Forest-Steppe of Ukraine.

Methods. Biological (conducting field research during 2017–2020) and statistical (descriptive statistics, analysis of variance, correlation and regression analyzes).

Results. The lowest yield of sweet sorghum green biomass was during harvesting in early August. In ‘Sylosne 42’ and ‘Favoryt’ varie­ties it was 52.6 and 61.1 t/ha, in ‘Medovyi F1’ and ‘Dovista’ hybrids – 76.3 and 77.7 t/ha, respectively. The postponement of harvesting to mid-September allows increasing the yield of varieties ‘Favoryt’ and ‘Sylosne 42’ to 97.1 and 103.5 t/ha, ‘Dovista’ and ‘Medovyi F1’ hybrids up to 146.6 and 132.9 t/ha, respectively. With even later harvesting periods, an increase in the yield of green biomass was observed only in ‘Dovista’ (up to 152.5 t/ha). In the full ripening phase (BBCH 92–98), sugar sorghum plants accumulate the maximum amount of sugars in the sap. The highest cap sugar content was in plants of ‘Medovyi F1’ hybrid – 17.5%, in the other studied cultivars it varied from 14.8 to 15.5%. The hi­g­hest yield of biofuel and energy per unit area was achieved with gro­wing ‘Dovista’ (up to 815.8 GJ/ha) and ‘Medovyi F1’ (up to 792.0 GJ/ha) hybrids. Despite the high level of plasti­city, ‘Favoryt’ variety is inferior in total energy yield (up to 547.2 GJ/ha). ‘Sylosne 42’ has the lowest plasticity index (b = 0.79); however, it is the most stable variety, which allows to obtain a stable, though not high, energy yield (up to 559.6 GJ/ha).

Conclusions. In the zone of insufficient moisture in the Eastern Forest-Steppe of Ukraine, the hi­ghest productivity indicators and the maximum energy potential can be provided by the hybrids of sweet sorghum ‘Dovista’ and ‘Medovyi F1’ for their harvesting not earlier than the phase of full maturity
The content of macro- and microelements in plants of the genus Artemisia under conditions of introduction in the M. M. Gryshko National Botanical Garden of the NAS of Ukraine
Authors: Коrablova O. A. , Rakhmetov D. B. , Shanaida M. I. , Vergun O. M. , Bagatska Т. S. , Svydenko L. V. , Ivashchenko I. V.
Published: November 2021

Purpose. To determine mineral composition of plants of species of the genus Artemisia (A. dracunculus L., A. abrotanum L. and A. argyi H.Lév. & Vaniot) to determine the possibility of their safe use in the food and pharmaceutical industries of Ukraine.
Methods. X‑ray fluorescence method for determining the elemental composition of plant raw materials.
Results. The content of mineral elements in plants of the genus Artemisia was determined depending on their ability to absorb elements from the soil and accumulate in the roots and organs of the aerial part was determined. The quantitative content of 21 macro- and microelements was established, and some peculiarities of their migration and distribution in the soil – roots – plant system were revealed. In particular, the aerial part of the studied plants contains K, Fe, Cu, Zn and Mn, which are the most important elements in the life of the plant organism. The content of mesoelements Ca and S is quite high. The amount of toxic elements Pb, Sr and Zr in plants is insignificant. Elements K and S accumulate in the aerial part. The content of elements in the aerial part of plants by decreasing their concentration can be represented in the form of the following series: for Artemisia dracunculus – S> K> Ca> Cl> Fe> Sr> Zn> Mn> Cu> Zr> Rb> Br> Cr; for A. abrotanum – K> Ca> S> Cl> Fe> Zn> Sr> Mn> Cu> Br> Cr> Co> Zr> Rb> Ni; for A. argyi – K> Ca> S> Fe> Cl> Sr> Zn> Mn> Co> Zr> Cu> Rb> Br> Se. The content of toxic elements in the studied plants was lower than the maximum allowable concentrations for plant raw materials and food.
Conclusions. For the first time under conditions of introduction in the M. M. Gryshko National Botanical Garden of the NAS of Ukraine in the plants Artemisia dracunculus, A. abrotanum and A. argyi the content of macro- and microelements, which are directly related to the metabolism of biologically active compounds, was determined. The peculiarities of their distribution by plant organs during the transition from soil to aboveground mass have been clarified. The obtained results can be used to evaluate and compare the quality of plant raw materials of the genus Artemisia, to determine the pharmacological properties of these plants associated with some elements of the mineral composition, and their use in the medical and food industries. The obtained data have both scientific and practical significance in the selection of economically valuable plant species for the enrichment of the cultivated flora of Ukraine.
Comprehensive analysis of water-sediment variation characteristics at the confluence of the upper reaches of the Weigan River and Heizi River with multiple methods and multiple influencing factors
Authors: Zhang Mingwang , Shi Kebin
Published: November 2021

In-depth analysis of the characteristics of water and sedimentary changes at the confluence of the upper reaches of Weigan River and Heizi River is the prerequisite and basis for studying the future water and sedimentary situation in the Kizil Reservoir. This article analyzes the trend, mutation point and periodicity of the water and sedimentary sequence with multi-methods. The double cumulative curve method and the attenuation analysis method were used to analyze the impact of precipitation and human activities on runoff and sedimentary transport, and other influencing factors were qualitatively analyzed also. The results showed that: (1) In the past 60 years, Kizil Reservoir's runoff and sedimentary transport have shown an upward trend; the mutation point of the reservoirs' runoff was in 1994; the annual runoff had a periodicity of 7, 13, and 28 years; the annual sedimentary transport had a periodicity of 4, 12, and 26 years. (2) The impact of precipitation and human activities on runoff were 485.37% and −385.37%, respectively; the impact of precipitation on sedimentary transport was first high and then low, while the impact of human activities on sedimentary transport was first low and then high. Solar activities, ENSO, underlying surface changes and glacier snow melt also contributes to water-sediment changes to some extent.
Modelling solution for estimating aeration energy of wastewater treatment plants
Authors: Pöyry Lauri , Ukkonen Petri , Mulas Michela , Mikola Anna
Published: November 2021

Energy costs in the wastewater industry are increasing due to increasing trends in electricity rates and more stringent requirements for effluent quality. Wastewater aeration process is typically the largest energy consumer of the treatment plant and the optimization of the aeration process can offer significant savings for the wastewater treatment plants (WWTPs). Utilization of dynamic models can offer optimization solutions for improving the energy efficiency and process performance. In this work a simplified modelling approach emphasizing the control valves and the blowers is tested by developing aeration system models for two Finnish WWTPs. The developed model requires calibration of only a single parameter and the results from the simulations showed that reasonable estimations of the aeration systems energy demand could be made with a limited knowledge on the details of the physical system. The promising results highlight the strong influence of the control valve positioning to the whole system and indicate that airflow distribution along the system could be estimated simply from the positioning of the valves. The presented modelling approach allows the comparison between different blower and control valve alternatives during operation and for the process upgrades and offers prospect for improving the aeration operation control strategies.
SÍNDROME INFLAMATÓRIA MULTISSISTÊMICA PEDIÁTRICA, POSSÍVEL COMPLICAÇÃO DA COVID-19 E UM DESAFIO PARA PROFISSIONAIS MÉDICOS : REVISÃO INTEGRATIVA
Authors: Linhares Farias Gita , Nunes Alves de Sousa Milena
Published: November 2021

Introdução: A Síndrome Inflamatória Multissistêmica Pediátrica (SIM-P) corresponde a uma entidade clínica rara e potencialmente fatal. O espectro clínico da SIM-P é variável e constituído por um conjunto de sinais e sintomas caracterizados pela presença de febre persistente associada a outras manifestações clínicas como a hipotensão. Objetivo: : Avaliar a Síndrome Inflamatória Multissitêmica Pediátrica (SIM-P) como uma provável complicação da COVID-19 em crianças e compreender os desafios clínicos e terapêuticos dos médicos de frente a essa síndrome.. Metodologia: Revisão integrativa da literatura, realizada em seis fases. Foi feita uma busca bibliográfica de evidências nas bases de dados eletrônicos da Scientific Electronic Library Online ( SciELO) e na Public Medline or Publisher Medline, para isso foram utilizados descritores selecionados a partir do Medical Subject Heading e associação entre eles:  “Multisystem inflammatory syndrome” AND “child” AND “COVID”. Resultados: Após análise, observou-se que os sintomas mais relatados pelos autores foram: febre (100%), problemas gastrointestinais (92,8%), disfunção cardíaca (100%), manifestações mucocutânea (100%) e a idade média de acometimento foi 6-10 anos (64,3%). Quanto ao tratamento, 100% dos estudos relataram a necessidade de hospitalização e 100% referiram que a administração de imunoglobulina intravenosa é uma ótima opção terapêutica. Conclusões: A SIM-P apresenta uma associação temporal, geográfica e laboratorial com a COVID-19, e corresponde a uma nova entidade clínica diferente da Doença de Kawasaki. O espectro clínico é diverso e quanto ao tratamento, é necessário mais estudos para determinar um tratamento específico para a doença e capaz de reduzir sua mortalidade.

Palavras-Chave: Crianças. Infecções por Coronavírus. Terapêutica.
Synthesis and Photophysical Properties of Benzo[c]phenanthrene
Derivatives
Authors: Hajri Amira K. , Albalawi Marzough A. , Moussa Souad A. , Aloui Faouzi
Published: November 2021

:

Three polycyclic aromatic hydrocarbons derived from benzo[c]phenanthrene have been
synthesized through a one-step procedure involving palladium Suzuki coupling and are characterized
by 1H and 13C NMR, MS and HRMS spectroscopies. UV-vis absorption and fluorescence
properties of these π-conjugated compounds have been evaluated in solutions and strong emission
in the blue region of the visible spectrum was noted. The optical spectra of these small polycyclic
aromatic compounds are unusual since absorption is entirely in the UV region (λmax = 281-285 nm),
yet fluorescence occurs at 410-422 nm. This equates to a Stokes shift of 1.32-1.39 eV (10756-
11256 cm−1) and is among the large Stokes shifts that have been reported for small molecules, making
them promising candidates for optoelectronic applications.
Cell-based Treatment of Cerebral Palsy: Still a Long Way Ahead
Authors: Sadr-Nabavi Ariane , Shariati Mohammad , Esfahani Reza Jafarzadeh , Bidkhori Hamid Reza , Sabouri Ehsan , Mehrzad Shadi
Published: November 2021

Background:

Cerebral palsy (CP) is a permanent neurodevelopmental disorder with considerable
global disability. Various rehabilitation strategies are currently available. However, none
represents a convincing curative result. Cellular therapy recently holds much promise as an alternative
strategy to repair neurologic defects.

Method:

In this narrative review, a comprehensive search of the MEDLINE and ClinicalTrials.gov
was made, using the terms: “cell therapy” and “cerebral palsy”, including published and registered
clinical studies, respectively.

Results:

The early effects of these studies demonstrated that using cell therapy in CP patients is
safe and improves the deficits for a variable duration. Despite such hopeful early bird results, the
long-term outcomes are not conclusive.

Conclusions:

Due to the heterogeneous nature of CP, personal factors seem essential to consider.
Cell dosage, routes of administration, and repeated dosing are pivotal to establish optimal personalized
treatments. Future clinical trials should consider employing other cell types, specific cell modifications
before administration, and cell-free platforms.
The Role of Eif2s3y in Mouse Spermatogenesis and ESC
Authors: Hua Jinlian , Liu Wenqing , Li Na , Zhang Mengfei , Arisha Ahmed H.
Published: November 2021

:

Eukaryotic translation initiation factor 2 subunit 3 and structural gene Y-linked
(Eif2s3y) gene, the gene encoding eIF2γ protein, is located on the mouse Y chromosome short arm.
The Eif2s3y gene is globally expressed in all tissues and plays an important role in regulating global
and gene-specific mRNA translation initiation. During the process of protein translation initiation,
Eif2s3x (its homolog) and Eif2s3y encoded eIF2γ perform similar functions. However, it has
been noticed that Eif2s3y plays a crucial role in spermatogenesis, including spermatogonia mitosis,
meiosis, and spermiogenesis of spermatids, which may account for infertility. In the period of spermatogenesis,
the role of Eif2s3x and Eif2s3y are not equivalent. Importance of Eif2s3y has been observed
in ESC and implicated in several aspects, including the pluripotency state and the proliferation
rate. Here, we discuss the functional significance of Eif2s3y in mouse spermatogenesis and
self-renewal of ESCs.
COVID19 - Far from Over: Call for Urgent Novel and Advanced Measures
Authors: Mukherjee Suprabhat , Choudhury Abhigyan
Published: November 2021

:

The COVID19 pandemic that started in late 2019 has already killed millions people, it is
yet far from over and the road to the COVID-free world is much tougher than we all imagined;
however, it ends at a vaccine functional against all coronaviruses. In this article, we try to present
the aetiology behind evolution of superior pathogenicity of SARS-CoV-2 and point out fundamental
and highly hazardous loopholes in the current vaccination regimens and propose new vaccination
strategies. We also suggest societal and personal level management that are necessary to ensure
prevention and better recovery outcomes until the arrival of the vaccine. In turn, we apprise
the physician for long-term and stringent management of certain chronic diseases, avoiding prescribing
certain drugs and suggesting physical exercises and diets that are fortified with specific micronutrients.
Switching Patients With Prostate Cancer from GnRH Antagonist to Long-acting LHRH Agonist for Androgen Deprivation: Reducing Hospital Visits During the Coronavirus Pandemic
Authors: FUJIWARA MOTOHIRO , YUASA TAKESHI , KOMAI YOSHINOBU , FUJIWARA RYO , OGUCHI TOMOHIKO , NUMAO NOBORU , YAMAMOTO SHINYA , YONESE JUNJI
Published: November 2021

Aim: To reduce the frequency of the need for hospital visits for patients with prostate cancer (PCa) taking androgen-deprivation therapy during the SARS-CoV-2 (COVID-19) pandemic, we switched them from gonadotropin-releasing hormone (GnRH) antagonist to a long-acting luteinizing hormone-releasing hormone (LH-RH) agonist. Here, we confirmed the efficacy and safety profile of this switching. Patients and Methods: We analyzed the medical records of 32 patients with PCa who received ADT and switched from GnRH antagonist to a long-acting LH-RH agonist during the COVID-19 pandemic, evaluating hematological and serological variables, including serum testosterone and prostate-specific antigen. Results: Before and after the switching from GnRH antagonist to LH-RH agonist, the median serum testosterone levels were 0.22 and 0.18 ng/ml, respectively, and the median serum prostatespecific antigen levels were 0.18 and 0.11 ng/ml, respectively. No changes in the rates of flare-ups of conditions or adverse events were observed. Conclusion: Switching from GnRH antagonist to a long-acting LH-RH agonist appears to be a reasonable option that does not diminish efficacy or exacerbate adverse events.
Visceral Adipose Mass and Radiation Pneumonitis After Concurrent Chemoradiotherapy in Patients With Non-small-cell Lung Cancer
Authors: KATSUI KUNIAKI , OGATA TAKESHI , SUGIYAMA SOICHI , YOSHIO KOTARO , KURODA MASAHIRO , YAMANE MASAOMI , HIRAKI TAKAO , KIURA KATSUYUKI , TOYOOKA SHINICHI , KANAZAWA SUSUMU
Published: November 2021

Aim: To investigate whether muscle and adipose mass are associated with radiation pneumonitis (RP) in patients with non-small cell lung cancer undergoing preoperative concurrent chemoradiotherapy. Patients and Methods: We calculated body mass index and determined skeletal muscle, psoas muscle, visceral adipose tissue (VAI), and subcutaneous adipose tissue indices, and visceral-to-subcutaneous adipose tissue area ratio for patients using computed tomography. We examined their relationship with grade 2 or more RP. Results: Among 94 patients, 28 experienced grade 2 or more RP. On multivariate analysis, only VAI was associated with grade 2 or more RP (all p=0.026). The 6-month incidence rates of grade 2 or more RP were 21.4% and 36.8% in patients with VAI 39 and ≥39 cm2/m2, respectively. Conclusion: High visceral adipose mass is associated with grade 2 or more RP in patients undergoing preoperative concurrent chemoradiotherapy. Measuring visceral adipose mass may help to predict RP occurrence. Further studies are needed to validate our findings.
Effect of Sucrose on Cisplatin-induced Fatigue-like Behavior in Mice: Comparison With Fructose and Glucose
Authors: YOSHIZAWA KAZUMI , KURONO RUKA , SATO HARUKA , ISHIJIMA ERIKA , NASU HARUKA , FERDAOS NURFARHANA , SUZUKI HIDETAKA , NEGISHI KENICHI
Published: November 2021

Background/Aim: Fatigue is the most common symptom in patients with cancer undergoing radiation therapy or cancer chemotherapy. However, cancer-related fatigue remains undertreated and poorly understood. Materials and Methods: Mice were administered a single dose of cisplatin (10 mg/kg, intraperitoneally) or saline (as a control) and then treated with sucrose, fructose, glucose (each at 500 or 5,000 mg/kg, orally), or saline (control) daily for 4 days. cisplatin-induced fatigue-like behavior was investigated by assessment of running activity on a treadmill. The influence of glucose intake on tumor growth was also examined in Lewis lung carcinoma (LLC)-bearing mice. Results: Administration of sucrose and glucose improved cisplatin-induced fatigue-like behavior in mice, whereas administration of fructose showed only slight antifatigue effects. Although glucose-fed mice showed increased tumor growth, this was balanced out by the powerful cytotoxicity of cisplatin. Conclusion: Sucrose, and especially glucose, may improve patient quality of life during treatment with anticancer agents by preventing fatigue without interfering with the antitumor effects of cisplatin.
Multimodal Evaluation of Voice Outcome in Early Glottic Cancers Treated With Definitive Radiotherapy
Authors: TRIGNANI MARIANNA , DI PILLA ANGELO , ROSA CONSUELO , BORGIA MARZIA , FASCIOLO DAVID , GASPARINI LUCREZIA , DI GUGLIELMO FIORELLA , ALLAJBEJ ALBINA , DI FRANCESCO MARTA , FALCONE GIANLUCA , VITULLO FRANCESCA , CROCE ADELCHI , GENOVESI DOMENICO , CARAVATTA LUCIANA
Published: November 2021

Background/Aim: We employed a multimodal evaluation of voice outcome (MEVO) model to assess long-term voice outcome in early glottic cancer (EGC) patients treated with primary radiotherapy (RT). The model consisted of objective and subjective vocal evaluation during follow-up, by a dedicated Speech Pathologist and Speech Therapist. Patients and Methods: MEVO methodology includes Self-perception Voice Handicap Index (VHI-30), evaluation of parameters Grade (G), Roughness (R), Breathiness (B), Asthenia (A) and Strain (S) according to GRBAS scale, objective analysis and aerodynamics using the PRAAT software and laryngeal evaluation with videostroboscope (VS). Results: The MEVO methodology was described and tested on a sample of 10 EGCs submitted to definitive RT (total dose 66-70 Gy). Mean follow-up was 48.9 months (range=9-115). VHI was mild-moderate in 90% of patients; overall voice function (GRBAS) was normal-mildly impaired in 70% of patients; VS evaluation showed normal vocal cord motion in 90% of patients, but complete glottic closure in 60%. PRAAT scores confirmed these findings. Conclusion: A multidimensional voice evaluation is time consuming, but useful to objectify vocal impact of radiotherapy. The MEVO model allowed to quantify vocal dysfunction, showing a good objective vocal outcome.
Improved Chemotherapy Outcomes of Patients With Small-cell Lung Cancer Treated With Combined Alkalization Therapy and Intravenous Vitamin C
Authors: HAMAGUCHI REO , NARUI RYOKO , MORIKAWA HIROMASA , WADA HIROMI
Published: November 2021

Background/Aim: This study aimed to investigate the effects of the combination of alkalization therapy (an alkaline diet and bicarbonate therapy) and intravenous vitamin C treatment on chemotherapy outcomes in patients with small-cell lung cancer (SCLC) (study registration: UMIN000043056). Patients and Methods: Twelve patients with SCLC in the intervention group (receiving both alkalization therapy and vitamin C treatment together with chemotherapy) were retrospectively compared to 15 patients with SCLC in the control group (receiving chemotherapy only). Results: The mean urine pH of the intervention group was significantly higher than that of the control group (7.32±0.45 vs. 6.44±0.74, respectively; p<0.005). The median overall survival for the intervention group was 44.2 months (95% confidence interval=22.0−not reached), as compared with 17.7 months for the control group (95% confidence intervaI=13.5−not reached; p<0.05). Conclusion: The combination of alkalization therapy and intravenous vitamin C treatment may be associated with favorable outcomes in patients with SCLC receiving chemotherapy.
Recurrence of Lymph Node Micrometastases After Radiotherapy for Head and Neck Carcinoma: A Propensity Score-matched Study
Authors: SUZUKI YU , JINGU KEIICHI , ISHIDA EIICHI , MURATA TAKAKI , KUBOZONO MASAKI
Published: November 2021

Background: The standard irradiation dose to the elective lymph node area (ELNA) in locally patients with advanced head and neck squamous cell carcinoma (LA-HNSCC) to control lymph node micrometastases (LN-MM) has not changed since it was empirically determined in the 1950s. We investigated the optimal irradiation dose for controlling LN-MM in ELNAs. Patients and Methods: The pattern of recurrence of LA-HNSCC was retrospectively evaluated in patients who underwent concurrent chemoradiotherapy with cisplatin or radiation therapy alone. Results: In total, 162 patients were enrolled. The median observation period was 34 months. No recurrence was found in ELNAs. After propensity score matching, a cisplatin dose of ≥200 mg/m2 yielded a significantly higher overall survival rate (p≤0.001) and locoregional control rate (p=0.034) than did a dose of <100 mg/m2. Conclusion: CCRT with a cisplatin dose of ≥200 mg/m2 can reduce the irradiation dose to 40-44 Gy at 2 Gy per fraction to control LN-MM.
Survival Benefit of Neoadjuvant Chemotherapy for Locally Advanced Adenocarcinoma of Esophagogastric Junction
Authors: SUZUKI SATOSHI , KANAJI SHINGO , URAKAWA NAOKI , TAKIGUCHI GOSUKE , HASEGAWA HIROSHI , MATSUDA YOSHIKO , YAMASHITA KIMIHIRO , MATSUDA TAKERU , OSHIKIRI TARO , NAKAMURA TETSU , KAKEJI YOSHIHIRO
Published: November 2021

Background/Aim: Adenocarcinoma of the esophagogastric junction (AEG) is refractory even when curative resection is followed by adjuvant chemotherapy. This study evaluated the efficacy of neoadjuvant chemotherapy (NAC) using an oral fluoropyrimidine-platinum regimen for AEG. Patients and Methods: Out of 35 patients with locally advanced AEG who underwent curative resection, 21 who underwent surgery first and 14 who received NAC were retrospectively compared in terms of survival. Results: The NAC regimens comprised of S-1 or capecitabine plus oxaliplatin or cisplatin; trastuzumab was added to six borderline resectable cases. The downstaging rate was 50% and the pathological response rate including complete response (29%) was 50%. The three-year relapse-free survival in the NAC group was significantly superior than the surgery-first group (78% vs. 22%, p=0.011). The NAC group had a significantly longer median survival time than the surgery-first group (NR vs. 29 months, p=0.032). Conclusion: NAC using an oral fluoropyrimidine-platinum regimen may provide survival benefit in AEG.
VMAT Planning With Xe-CT Functional Images Enables Radiotherapy Planning With Consideration of Lung Function
Authors: UTSUMI NOBUKO , TAKAHASHI TAKEO , HATANAKA SHOGO , HARIU MASATSUGU , SAITO MIO , KONDO SHUICHI , SODA RIKANA , NISHIMURA KEIICHIRO , YAMANO TAKAFUMI , WATANABE WATARU , SHIMBO MUNEFUMI , HONDA NORINARI
Published: November 2021

Background/Aim: The most severe adverse event of radiotherapy in lung cancer is radiation pneumonitis (RP). Some indices commonly used to prevent RP are evaluated based on the anatomical lung volume. The irradiation dose may be more accurately assessed by using functional lung volume. We evaluated the usefulness of computed tomography (CT) incorporating functional ventilation images acquired by the inhalation of xenon (Xe) gas (Xe-CT functional images). Patients and Methods: Two plans were created for twelve patients: volumetric modulated arc therapy (VMAT) planning using conventional chest CT images (anatomical plans) and VMAT planning using Xe-CT functional images (functional plans), and the dosimetric parameters were compared. Results: Compared to the anatomical plans, the functional plans had significantly reduced V20Gy in the high-functional lungs (p=0.005), but significant differences were not seen in the moderate-functional and low-functional lungs. Conclusion: The incorporation of Xe-CT functional images into VMAT plans enables radiotherapy planning with consideration of lung function.
Successful Response to Nivolumab Plus Ipilimumab Therapy in a Hemodialysis Patient With Metastatic Renal Cell Carcinoma
Authors: MASUDA HIROSHI , MIKAMI KOSUKE , OTSUKA KOTARO , HOU KYOKUSIN , SUYAMA TAKAHITO , ARAKI KAZUHIRO , KOJIMA SATOKO , NAYA YUKIO
Published: November 2021

Background/Aim: There are few reports about the administration of nivolumab plus ipilimumab to hemodialysis patients and their efficacy and safety have not been established yet. Case Report: A 74-year-old male, who was receiving hemodialysis, was presented with metastatic renal cell carcinoma (mRCC). Two years later, more metastases were found, hence, immunotherapy involving nivolumab plus ipilimumab was initiated. After two doses of immunotherapy, interstitial pneumonia was observed. Thus, steroid pulse therapy was administered immediately. Subsequently, computed tomography (CT) findings and symptoms improved markedly. One month later, a CT scan showed a nodular shadow and an air cavity. A fungal infection was strongly suspected, so an antifungal drug was administered. Conclusion: Combination immunotherapy with nivolumab plus ipilimumab was demonstrated to be effective in a hemodialysis patient with mRCC.
Proteomic Analysis of the Non-genetic Response to Cisplatin in Lung Cancer Cells
Authors: DE SOUZA DUTRA CRISTINE , LUMERTZ MARTELLO CAROLINA , CADORE NATHAN ARAUJO , FERREIRA HENRIQUE BUNSELMEYER , ZAHA ARNALDO , MONTEIRO KARINA MARIANTE
Published: November 2021

Background: Drug resistance is the main cause of therapy failure in advanced lung cancer. Although non-genetic mechanisms play important roles in tumor chemoresistance, drug-induced epigenetic reprogramming is still poorly understood. Materials and Methods: The A549 cell line was used to generate cells with non-genetic resistance to cisplatin (CDDP), namely A549/CDDP cells. Bioorthogonal non-canonical amino acid tagging (BONCAT) and mass spectrometry were used to identify proteins modulated by CDDP in A549 and A549/CDDP cells. Results: Proteins related to proteostasis, telomere maintenance, cell adhesion, cytoskeletal remodeling, and cell redox homeostasis were found enriched in both cell lines upon CDDP exposure. On the other hand, proteins involved in drug response, metabolic pathways and mRNA processing and splicing were up-regulated by CDDP only in A549/CDDP cells. Conclusion: Our study revealed proteome dynamics involved in the non-genetic response to CDDP, pointing out potential targets to monitor and overcome epigenetic resistance in lung cancer.