bluuebunny/crossref_metadata_2025 huggingface dataset:
Jagged1 Acts as an RBP-J Target and Feedback Suppresses TNF-Mediated Inflammatory Osteoclastogenesis
Authors: Ng Courtney , Qin Yongli , Xia Yuhan , Hu Xiaoyu , Zhao Baohong
Published: September 2023

TNF plays a crucial role in inflammation and bone resorption in various inflammatory diseases, including rheumatoid arthritis (RA). However, its direct ability to drive macrophages to differentiate into osteoclasts is limited. Although RBP-J is recognized as a key inhibitor of TNF-mediated osteoclastogenesis, the precise mechanisms that restrain TNF-induced differentiation of macrophages into osteoclasts are not fully elucidated. In this study, we identified that the Notch ligand Jagged1 is a previously unrecognized RBP-J target. The expression of Jagged1 is significantly induced by TNF mainly through RBP-J. The TNF-induced Jagged1 in turn functions as a feedback inhibitory regulator of TNF-mediated osteoclastogenesis. This feedback inhibition of osteoclastogenesis by Jagged1 does not exist in RANKL-induced mouse osteoclast differentiation, as RANKL does not induce Jagged1 expression. The Jagged1 level in peripheral blood monocytes/osteoclast precursors is decreased in RA compared with the nonerosive inflammatory disease systemic lupus erythematosus, suggesting a mechanism that contributes to increased osteoclast formation in RA. Moreover, recombinant Jagged1 suppresses human inflammatory osteoclastogenesis. Our findings identify Jagged1 as an RBP-J direct target that links TNF and Notch signaling pathways and restrains TNF-mediated osteoclastogenesis. Given that Jagged1 has no effect on TNF-induced expression of inflammatory genes, its use may present a new complementary therapeutic approach to mitigate inflammatory bone loss with little impact on the immune response in disease conditions.
In vitro effect of anodization of titanium abutments on their tensile bond strength to implant-supported lithium disilicate all-ceramic crowns
Authors: Pour Hamed Karimi , Ansari Homeira , Tehrani Azita Mazaheri
Published: September 2023

Background:

The retention of cement-retained implant-supported restorations can be affected by surface treatments such as anodizing. This study aimed to assess the effect of the anodization of titanium abutments on their tensile bond strength to implant-supported lithium disilicate (LDS) all-ceramic crowns.

Materials and Methods:

This in vitro, experimental study was conducted on 26 straight abutments in two groups of anodization and control. In the anodization group, seven flat 9 V batteries connected in series were used to generate 64 V energy. A glass container was filled with 250 mL of distilled water, and 1 g of trisodium phosphate was added to it to create an electrolyte solution. The anode was then disconnected and the abutment was rinsed with acetone and deionized water. The surface roughness of abutments was measured by a profilometer. The abutments were scanned by a laboratory scanner, and maxillary central incisor monolithic crowns were fabricated by inLab SW18 software. The crowns were seated on the abutments and temporarily cemented with TempBond. They were then incubated in artificial saliva and subjected to 5000 thermal cycles. The tensile bond strength of crowns was then measured. Data were analyzed by the Student's t-test and Mann–Whitney U-tests (α =0.05).

Results:

The mean bond strength was significantly higher in anodized abutments (P = 0.003). The surface roughness of anodized abutments was slightly, but not significantly, higher than that of the control group (P > 0.05). The frequency of adhesive failure was almost twice higher in anodized abutments.

Conclusion:

Anodization of titanium abutments significantly improved their tensile bond strength to implant-supported LDS all-ceramic crowns.
Effect of a novel rotation coordinating device on registered horizontal condylar guidance of nonarcon semi-adjustable articulators
Authors: Manshaee Farbod , Najatidanesh Farahnaz , Savabi Omid , Atash Ramin
Published: September 2023

Background:

Horizontal condylar guidance (HCG) is registered by protrusive interocclusal records but in nonarcon articulators, these records can affect the accuracy. The present study aimed to evaluate the effect of a novel rotation coordinating device (RCD) on condylar guidance setting with protrusive interocclusal records.

Materials and Methods:

The study was designed as a comparative in-vitro investigation. Stone maxillary and mandibular casts were mounted on a fully adjustable instrument as the patient. Duplicate casts were mounted on an arcon and a nonarcon articulator with corresponding face bow records and in maximum intercuspation relation. Five different condylar guidance inclinations for both sides (20°, 30°, 40°, 50°, and 60°) were set on the fully adjustable instrument and 16 protrusive interocclusal records were established at each setting. HCG was set for arcon, nonarcon articulators, and nonarcon articulators with RCD. Data were analyzed using one-sample t-test to compare with actual HCG and one-way analysis of variance (α =0.05).

Results:

Mean HCG for studied articulators was 35.40 for arcon, 30.31 for nonarcon without RCD, and 35.61 for nonarcon with RCD which were significantly different from actual HCG (P < 0.05). HCG of the nonarcon with RCD showed no significant difference with arcon articulator (P = 0.71) while both were significantly different from nonarcon without RCD (P < 0.001).

Conclusion:

“The RCD” compensates the condylar guidance inclination difference between arcon and nonarcon articulators. The device precisely transfers the hinge movement of the upper member of the articulator to the condylar track.
Metabolomics in drug discovery: Restoring antibiotic pipeline
Authors: Azhar Faiza , Busharat Mariam , Chaudhary Shah Rukh Arshad , Waheed Zainab , Jamil Muhammad Nauman
Published: September 2023

Metabolomics has emerged as a valuable tool in drug discovery and development, providing new insights into the mechanisms of action and toxicity of potential therapeutic agents. Metabolomics focuses on the comprehensive analysis of primary as well as secondary metabolites, within biological systems. Metabolomics provides a comprehensive understanding of the metabolic changes that occur within microbial pathogens when exposed to therapeutic agents, thus allowing for the identification of unique metabolic targets that can be exploited for therapeutic intervention. This approach can also uncover key metabolic pathways essential for survival, which can serve as potential targets for novel antibiotics. By analyzing the metabolites produced by diverse microbial communities, metabolomics can guide the discovery of previously unexplored sources of antibiotics. This review explores some examples that enable medicinal chemists to optimize drug structure, enhancing efficacy and minimizing toxicity via metabolomic approaches.
Clinical profile of febrile encephalopathy patients at a tertiary care hospital in India: A retrospective study
Authors: Sengupta Sanjeev , Shukla Ashish Kumar , Kishore Kunal , Goel Jitesh , Ghosh Amlan
Published: September 2023

Objective:

To investigate demography, etiology, and clinical profile and to analyze the outcomes of patients presenting with febrile encephalopathy at a tertiary care center in Eastern India.

Methods:

This retrospective, observational study included a total of 50 patients (>18 years) who presented with fever and encephalopathy. All patients underwent blood analysis; culture test for blood, urine, sputum, cerebrospinal fluid, and other body fluids; chest and abdominal ultrasonography; neuroimaging; polymerase chain reaction test, and other relevant tests as and when applicable.

Results:

The mean age of all enrolled patients was (58.0±16.0) years with male to female ratio of 1.27:1. Viral encephalitis was diagnosed in 16 (32%) patients, sepsis-associated encephalitis in 14 (28%), bacterial meningoencephalitis in 8 (16%) and tuberculosis meningoencephalitis in 5 (10%). The mean hospital stay was 10 (4, 17) days. At 6-month follow-up, 10 (20%) patients died, 10 (20%)patients recovered with sequelae (cognitive impairment, critical careneuropathy, etc.), and 30 (60%) patients recovered without sequelae. A statistically significant association was noted between GlasgowComa Scale (<8) and mortality rate (P=0.02).

Conclusions:

Primary central nervous system infection is the mostfrequent etiology of febrile encephalopathy and viral encephalitisis the most common etiological cause. Accurate, systematic, timelydiagnosis and management are prime factors to reduce mortality andmorbidity.
Molecular and Antigen Detection, Phylogenetics, and Immunoinformatics Study of the Zoonotic Coronavirus in Iranian Diarrheic Calves
Authors: Enayati Soodeh , Ranjbar Mohammad M. , Hooshmandi Soodeh , Ahangarzadeh Shahrzad , Aboutalebian Shima
Published: September 2023

Background:

Bovine coronaviruses (BCoVs) are zoonotic diseases that result in substantial economic losses due to mortality, impaired growth, and increased medication expenses in large animals. These viruses pose a risk to children who live beside infected animal, as they can cause diarrhea. This study was dedicated to molecular and antigen detections and phylogenetic and immunoinformatics analysis of zoonotic coronavirus (CoV) in Iran.

Materials and Methods:

A total of 77 diarrheic samples were collected from Holstein dairy herds in selected provinces of Iran. Samples were tested by capture antibody enzyme-linked immunosorbent assay (ELISA) to detect CoV and reverse transcriptase–polymerase chain reaction (RT–PCR) for verification of detection and also genotyping of spike glycoprotein in CoV-positive samples. After statistical analysis, nucleotide sequence alignment, and nucleotide and protein phylogenetic tree construction, the centralized sequence for vaccine strains was obtained using computationally optimized broadly reactive antigen (COBRA)'s center-of-the-tree (COT) method.

Results:

Twenty-two (28.5%) and eight (10.3%) of 77 samples were positive according to RT–PCR and ELISA, respectively. (Basic Local Alignment Search Tool) BLAST and phylogenetic analysis revealed that most similar sequences to the Iranian CoV sequence were for European countries. Furthermore, there were strong correlations to other CoVs in humans and wild and domesticated animals. As CoV has variable COT, the most recent strains and COBRA vaccine strains were obtained.

Conclusion:

Based on the high prevalence of this viral disease in calves and its economic impact on the breeding industry, as well as the potential transmission to humans and correlation with World Health Organization (WHO) One Health approach guidelines, the study emphasizes the importance of implementing preventive strategies such as animal vaccination.
Positive malaria rapid test in asymptomatic blood donor – Undetectable parasitemia or false positive?
Authors: Banerjee Soumee , Ashok H. M.
Published: September 2023

A 35-year-old male, first-time whole blood donor, cleared for donation by physical examination and donor questionnaire, tested reactive for malaria by rapid diagnostic test (RDT). Tests done in triplicate with bag segment samples gave the same results. He had no history of travel to endemic areas or of features suggestive of or a confirmed diagnosis of malaria or its treatment. There was also no history of any prolonged illness or medications. Repeat physical examination was unremarkable, he had no history of fever postdonation and repeat samples showed a normal hemogram, negative for malaria parasite by thick and thin smears and RDT. Further work-up, such as nucleic acid testing or quantitative polymerase chain reaction, was not done due to financial constraints and nonsuggestive history, physical examination, and laboratory tests. The unit was discarded, however, since asymptomatic, low-dose parasitemia could not be ruled out, it could not be definitively labeled false positive.
Evaluation of Effects of Scaling with and without Polishing on Oral Hygiene Clinical Parameters – A Concurrent Parallel Randomized Trial
Authors: Shanmugam Shankar , Sundararajan Shanmathi , Yasin Mohamed , Muthu Karthikka Sai , Shavi Girish R. , Murali Kruthika
Published: September 2023

Introduction:

Good oral health is a crucial indicator of overall well-being. Oral hygiene maintenance and care is the practice of keeping the oral cavity clean and disease free. The main objective of this study was to evaluate the effects of scaling and polishing on oral hygiene clinical parameters at different intervals.

Materials and Methods:

A concurrent parallel randomized trial was carried out among 60 college students in the Namakkal district. Subjects were randomly assigned into two groups, the scaling followed by the polishing group and the scaling without polishing group. This was a three-point assessment (baseline, 2nd week, and 3rd week) for plaque, gingival, and marginal line calculus index scores. Data were analyzed using parametric tests: independent t-test and repeated measures ANOVA.

Results:

A statistically significant difference was found for all three clinical parameters at the final 3rd-week follow-up between the two groups. Between the intervals, both the groups had a significant difference (P < 0.05) for plaque, gingival, and calculus index.

Conclusion:

Scaling followed by polishing had better results when compared to scaling without polishing. Microlocal irregularities, caused by scaling procedures, might be the cause for further accumulation of debris which can be reduced by polishing procedures.
An Analysis of Psychiatric Morbidity and Its Related Factors in Ambulance Workers
Authors: Lebimoyo Azizat Abiodun , Sanni Mumtaz Oladipupo
Published: September 2023

Objectives:

Ambulance workers belong to a high-risk occupational group, facing constant threats to their health and lives. Therefore, they are prone to mental health problems such as burnout, depression, and anxiety. A review of the literature has shown a scarcity of data concerning the magnitude and predictors of these psychiatric morbidities among Nigerian ambulance workers. In this study, we intended to determine the prevalence of burnout, the prevalence and predictors of depression and anxiety, as well as the relationship between burnout, depression, and anxiety among ambulance workers in Lagos, Nigeria.

Methods:

This was a cross-sectional study of 94 ambulance workers who were chosen using systematic random sampling. Copies of questionnaire used were the Maslach Burnout Inventory, the Hospital Anxiety and Depression Scale, as well as a sociodemographic questionnaire.

Results:

Mean scores ± standard deviation for burnout were emotional exhaustion (EE) 12 ± 9, depersonalization (DP) 7 ± 3, and personal achievement (PA) 36 ± 12. Furthermore, 12%, 34%, and 61% of the sample had high EE, high DP, and low PA, respectively. The prevalence of 34% and 52% was reported for depression and anxiety, respectively. Predisposing factors for depression were significantly to be female gender (p < 0.05), being married (p = 0.01), junior cadre (p < 0.05), and EE (p = 0.001). For anxiety, junior cadre (p < 0.01), EE (p < 0.01), and PA (p = 0.001) were predisposing factors.

Conclusion:

Ambulance workers suffer from diverse forms of psychiatric morbidities which have long-term effects on their mental health. There is a need for more support systems for ambulance workers to avert the occurrence of emotional problems in them.
Tools and Process of Defect Detection in Automated Manufacturing Systems
Authors: Al-Jubori Hussein N. , Al-Darraji Izzat
Published: September 2023

INTRODUCTION: A range of tools and technologies are at disposal for the purpose of defect detection. These include but are not limited to sensors, Statistical Process Control (SPC) software, Artificial Intelligence (AI) and machine learning (ML) algorithms, X-ray systems, ultrasound systems, and eddy current systems.
OBJECTIVES: The determination of the suitable instrument or combination of instruments is contingent upon the precise production procedure and the category of flaw being identified. In certain cases, defects may necessitate real-time monitoring and analysis through the use of sensors and SPC software, whereas more comprehensive analysis may be required for other defects through the utilization of X-ray or ultrasound systems.
METHODS: The utilization of AI and ML algorithms has gained significant traction in the realm of defect detection. This is attributed to their ability to process vast amounts of data and discern patterns that may have otherwise eluded detection. The aforementioned tools have the capability to anticipate potential flaws and implement pre-emptive measures to avert their occurrence.
RESULTS: The detection of defects in automated manufacturing systems is a continuous process that necessitates meticulous observation and examination to guarantee prompt and effective identification and resolution of defects. CONCLUSION: The utilization of suitable tools and technologies is imperative for manufacturers to guarantee optimal production quality and operational success.
Role of pulmonary perfusion magnetic resonance imaging for the diagnosis of pulmonary hypertension: A review
Authors: Lacharie Miriam , Villa Adriana , Milidonis Xenios , Hasaneen Hadeer , Chiribiri Amedeo , Benedetti Giulia
Published: September 2023

Among five types of pulmonary hypertension, chronic thromboembolic pulmonary hypertension (CTEPH) is the only curable form, but prompt and accurate diagnosis can be challenging. Computed tomography and nuclear medicine-based techniques are standard imaging modalities to non-invasively diagnose CTEPH, however these are limited by radiation exposure, subjective qualitative bias, and lack of cardiac functional assessment. This review aims to assess the methodology, diagnostic accuracy of pulmonary perfusion imaging in the current literature and discuss its advantages, limitations and future research scope.
Macierzyństwo jako temat publikacji i element wizerunków medialnych kobiet świata polityki w wybranych polskich tygodnikach opinii
Authors: Brzoza-Kolorz Katarzyna
Published: September 2023

Celem prowadzonych analiz jest pokazanie, jak ukazywano macierzyństwo w czterech polskich tygodnikach opinii: Gazecie Polskiej, Newsweeku Polsce, Polityce i Wprost, w wyselekcjonowanych okresach, na przestrzeni lat 2000–2019, oraz jak rola matki rzutowała na wizerunki medialne kobiet świata polityki. Przyjęto wstępne założenia, że macierzyństwo jest w badanych publikacjach upolitycznione, a linia redakcyjna analizowanych tygodników wpływa

na sposób pisania o nim. Ponadto starano się sprawdzić słuszność twierdzenia, że częściej w roli matki ukazywano żony polityków niż polityczki, a rolę matki mocniej eksponowano w obrazie polityczki polskiej niż zagranicznej. Wykorzystaną metodą badawczą była analiza zawartości wybranych publikacji pochodzących z tygodników opinii, którą przeprowadzono autorskim kluczem kategoryzacyjnym i przy wsparciu programu IBM SPSS. W toku prowadzonych analiz osiągnięto cele badawcze i potwierdzono przyjęte hipotezy.

Motherhood as a Topic of Publication and an Element of Media Images of Women of the Political World in Selected Polish Opinion Weeklies: The aim of the analysis conducted is to show how motherhood was portrayed in four Polish weekly opinion magazines Gazeta Polska, Newsweek Polska, Polityka and Wprost, during selected periods, over the years 2000-2019, and how the role of the mother projected media images of women in the world of politics. Preliminary assumptions were made that motherhood is politicised in the publications and that the editorial line of the surveyed weeklies influences the way they write about it. In addition, an attempt was made to test the validity of the claim that wives of politicians were more often portrayed in the role of the mother than female politicians, and the role of the mother was more strongly exposed in the portrayal of Polish female politicians than foreign ones. The research method used was a content analysis of selected publications, sourced from weekly opinion magazines, which was carried out based on the author’s categorisation key and with the support of the IBM SPSS program. In the course of the conducted analyses, the research objectives were achieved and the adopted research hypotheses were confirmed.
Multivariable Prediction Models for Traumatic Spinal Cord Injury: A Systematic Review
Authors: Hakimjavadi Ramtin , Basiratzadeh Shahin , Wai Eugene K. , Baddour Natalie , Kingwell Stephen , Michalowski Wojtek , Stratton Alexandra , Tsai Eve , Viktor Herna , Phan Philippe
Published: September 2023

Background:

Traumatic spinal cord injuries (TSCI) greatly affect the lives of patients and their families. Prognostication may improve treatment strategies, health care resource allocation, and counseling. Multivariable clinical prediction models (CPMs) for prognosis are tools that can estimate an absolute risk or probability that an outcome will occur.

Objectives:

We sought to systematically review the existing literature on CPMs for TSCI and critically examine the predictor selection methods used.

Methods:

We searched MEDLINE, PubMed, Embase, Scopus, and IEEE for English peer-reviewed studies and relevant references that developed multivariable CPMs to prognosticate patient-centered outcomes in adults with TSCI. Using narrative synthesis, we summarized the characteristics of the included studies and their CPMs, focusing on the predictor selection process.

Results:

We screened 663 titles and abstracts; of these, 21 full-text studies (2009-2020) consisting of 33 distinct CPMs were included. The data analysis domain was most commonly at a high risk of bias when assessed for methodological quality. Model presentation formats were inconsistently included with published CPMs; only two studies followed established guidelines for transparent reporting of multivariable prediction models. Authors frequently cited previous literature for their initial selection of predictors, and stepwise selection was the most frequent predictor selection method during modelling.

Conclusion:

Prediction modelling studies for TSCI serve clinicians who counsel patients, researchers aiming to risk-stratify participants for clinical trials, and patients coping with their injury. Poor methodological rigor in data analysis, inconsistent transparent reporting, and a lack of model presentation formats are vital areas for improvement in TSCI CPM research.
Performance Analysis of Budget Implementation During the Covid-19 Pandemic at the Technical Implementation Unit of the Immigration Office Class I TPI Kendari
Authors: Usman Mutiara Fajar , Supriyadi Supriyadi , Razak Abdul
Published: September 2023

Mutiara Fajar Usman, 2022 “Analysis of Budget Execution Performance During Covid-19 Pandemic at The Technical Unit Kantor Imigrasi Kelas I TPI Kendari”. Thesis. Accounting Study Program, Sekolah Tinggi Ilmu Ekonomi Enam Enam Kendari. Advisors (I) Abdul Razak, Adviser (II) Nita Hasnita. This study used to analyze the performance of budget execution during the 2020 and 2021 Covid-19 pandemics at the technical unit of Kantor Imigrasi Kelas I TPI Kendari based on Regulation of the Direktur Jenderal Perbendaharaan Number PER-4/PB/2020 concerning Technical Instructions for Assessment of Performance Implementation of Ministry/Agency Expenditure Budget Indicators.This study uses a qualitative descriptive technique. Data obtained by primary data derived from interviews and secondary data derived from 2020 and 2021 Budget Implementation Performance Indicators Report at Kantor Imigrasi Kelas I TPI Kendari. Analysis inductive uses based on the results. The results of this study indicate that Kantor Imigrasi Kelas I TPI Kendari increase in the final score of budget execution performance indicators, but there were decreased on several indicators.
Synthesis of Li7P3S11 Solid Electrolyte for All-Solid-State Lithium-Sulfur Batteries
Authors: TÜRK Çağrı Gökhan , TOKUR Mahmud
Published: September 2023

Sulfur-containing solid electrolytes are highly attractive to scientists and are increasing day by day. Recently, Li7P3S11, Li10GeP2S12, and Li11Si2PS12 solid electrolytes have been of great interest in literature. The ionic conductivity of these electrolytes can even be reached a value of 10-2 S/cm. For this purpose, Li7P3S11 solid electrolyte is synthesized by mechanical alloying method for all-solid-state Lithium Sulfur batteries in this study. To do this, Li2S and P2S5 ingredients were mixed in a ball mill at certain stoichiometric ratios. The crystallization temperatures of the obtained powders were determined by the DSC thermal analysis method, and they were crystallized under a protective atmosphere at the appropriate crystallization temperature. Then, the obtained powders, very sensitive to the open atmosphere, were subjected to XRD and Raman analysis with a custom-made trap. Structurally characterized powders were electrochemically tested with electrochemical impedance spectroscopy and cyclic voltammetry analyses in a special solid-state cell. It has been observed that the results are compatible with the literature, and it has been determined that the synthesized electrolyte can be used as a suitable candidate for lithium sulfur batteries.
THE EFFECT OF SUBCUTANEOUS TUNNELING ON EXTERNAL LUMBAR DRAINAGE COMPLICATIONS
Authors: UYSAL Ece
Published: September 2023

Introduction

Patients with a lumbar catheter become prone to infection due to the outflow of CSF. This research aimed to investigate how tunneled lumbar drainage affected infection in patients undergoing lumbar drainage.

Materials and Methods

This study was conducted on patients with lumbar drainage who were hospitalized for various clinical reasons. Subcutaneous drain length was measured by post-procedural lumbar tomography. The length of the lumbar drainage catheter, the duration of lumbar drainage, fever monitoring, CSF leakage, biochemical blood tests, the length of hospitalization, infection were recorded.

Results

This study comprised a total of 93 cases with external lumbar drainage. 51 (54.8%) of the 93 cases were inserted using the classic technique, 42 (45.2%) were inserted using the tunneled technique. The rate of CSF leakage was decreased using the tunneling approach (p = 0.003). A significant correlation was established between CSF leakage around the drain and subcutaneous drain length. CSF culture was negative in 78.8% of patients with subcutaneous drain lengths between 0 cm and 3 cm, and 100% of patients with subcutaneous drain lengths of 5 cm or more. Seven days or less was the cutoff value for negative CSF culture.

Conclusion

External lumbar draining can lead to issues such as infection and CSF leakage. The tunneling procedure is straight forward, affordable, and successfully prevents these complications.
Retrospective Evaluation of Vitamin D Levels According to Age, Gender and Seasonal Characteristics: Ardahan
Authors: YAŞAR Ümit
Published: September 2023

In recent years, there has been an increase in vitamin D tests in order to determine the prevalence and definition of vitamin D deficiency, which is clinically recognized to be associated with many diseases. The increase in vitamin-supported supplements is also related to this. This deficiency, which is tried to be prevented by taking precautions such as sun exposure, food and diet in local conditions, is tried to be prevented by health professionals with guidance, supervision and drug supplementation. This study covers the dates of 2022 and before. All patient data were randomly obtained from hospital automation (Göle state hospital) and then 25(OH)D levels were retropectively analyzed (Ardahan University Scientific Research and Publication Ethics Committee approval (Approval Date: 14.12.2022- No: E-67796128-000-2200037489). The findings of the study showed that vitamin D levels were insufficient (
EFFECT OF VARIOUS CARBON SOURCES ON THE GROWTH PROPERTIES AND MORPHOLOGY OF $SPIRULINA~PLATENSIS$
Authors: Harutyunyan Ani A. , Manoyan Jemma G. , Hambaryan Lusine R. , Gabrielyan Lilit S.
Published: September 2023

Cyanobacteria generate biomass under photoautotrophic conditions during photosynthesis. Cultivation of cyanobacteria under photoheterotrophic conditions using various organic carbon sources can increase yield of biomass. In the current study, the effect of organic carbon sources on the growth properties and morphology of cyanobacteria Spirulina platensis, as well as the production of the photosynthetic pigments: chlorophyll a, carotenoids, and phycocyanin were investigated. Carbon sources, such as glucose, fructose and succinate, caused not only an increase in the cyanobacterial growth rate, but also morphological changes in S. platensis trichomes. An increase in the amounts of photosynthetic pigments was also observed. Thus, glucose, fructose, and succinate are more efficient substrates for photoheterotrophic cultivation of these cyanobacteria.
VISCOSITY AND HALL EFFECTS ON UNSTEADY MHD CASSON FLUID FLOW THROUGH A PARALLEL POROUS PLATE
Authors:   Federal University Wukari, Wukari, Taraba State, Nigeria, Anyanwu E.O. , Raymond D. ,   Federal University Wukari, Wukari, Taraba State, Nigeria
Published: September 2023

This study investigates the temperature viscosity and Hall effects of a Casson fluid flow through a porous medium of a viscous incompressible fluid bounded by two parallel porous plates under the influence of thermal radiation and chemical reaction. A uniform suction and injection are applied perpendicular to the plates while the fluid motion is subjected to variable pressure gradient. The transformed conservation equations are solved analytically subject to physically appropriate boundary conditions by using perturbation and Eigenfunction expansion techniques. The influence of a number of emerging non-dimensional parameters namely, variable pressure gradient parameter, suction parameter, radiation parameter and Hartman number are examined. It is observed that the primary velocity profile is increased with increasing temperature dependent viscosity while increase in Hall parameter leads to increase in secondary velocity profile of the flow.
The Relationship of Perceptions, Subjective Norms, and Beliefs towards Immunization Vaccine Hesitancy in Children
Authors:   Department of Public Health, Postgraduate, Gorontalo State University, Gorontalo City, Indonesia, Ningrum Alaina Kristin , Jusuf Herlina ,   Department of Public Health, Postgraduate, Gorontalo State University, Gorontalo City
Published: September 2023

Refusal to vaccinate also occurs in Indonesia, primarily because people are reluctant to provide basic immunizations to their children. Some of these reasons need to be clarified about immunization information. This research aims to determine the relationship between perceptions, subjective norms, and beliefs regarding the hesitancy of childhood immunization vaccines. The research method used was analytical observational with a cross-sectional approach using the chi-square test. The population is mothers with children aged two years or who have passed the immunization schedule for children aged 2 years, numbering 13,052 people. The sampling method used cluster sampling using the sample size formula, according to Slovin, to obtain a sample size of 389 people. The results show a relationship between perception and hesitancy of children's immunization vaccines with a P-value = 0.003 (<0.05). There is a relationship between subjective norms and child immunization vaccine hesitancy with a P-value = 0.001 (<0.05). A relationship exists between confidence and hesitation about children's immunization vaccines with a P-value = 0.000 (<0.05). The conclusion is that there is a relationship between perception, subjective norms, and beliefs on the hesitancy of immunization vaccines in children.
Fixed Point Theorems for Semigroups of Lipschitzian Mappings
Authors: Marom Saiful , Istiqlal Muhammad
Published: September 2023

The main purpose of this paper is to extend the results of fixed point theorems for lipschitzian semigroups. The proofs we give follow the results of Ishihara, Suantai and Puengrattana theorems. Using one of the proofs, we also develop a fixed point theorem result for nonempty asymptotically total mapping semigroups on uniformly convex Banach spaces.
PENGARUH SIKAP EMPATI TENAGA KESEHATAN TERHADAP KEPUASAN PASIEN: META ANALISIS
Authors: Rahayuningsih Lilik Anggar Sri , Cahyaningrum Nopita
Published: September 2023

Kepuasan pasien merupakan harapan yang di inginkan masyarakat dalam memperoleh pelayanan kesehatan. Kepuasan pasien merupakan gambaran mutu pelayanan, apabila pasien merasa puas maka dapat dinyatakan pelayanan kesehatan  bermutu. Salah satu dimensi mutu dalam pelayanan kesehatan yaitu empati. Sikap empati tenaga kesehatan yaitu hubungan komunikasi yang baik dan memahami kebutuhan pasien. Dimensi ini sangat berperan dalam memenuhi kepuasan pasien karena langsung berhadapan dengan pasien. Penelitian ini bertujuan untuk menganalisis pengaruh sikap empati tenaga kesehatan terhadap kepuasan pasien. Metode yang digunakan yaitu meta analisis dilakukan dengan PICO sebagai berikut: Populasi pada penelitian ini adalah pasien. Intervensi berupa tenaga kesehatan dengan sikap empati. Comparison berupa tenaga kesehatan tidak bersikap empati. Outcome berupa peningkatan kepuasan pasien. Studi meta-analisis diterapkan pada penelitian ini dengan sumber data elektronik: Google Scholar dan Pubmed. Artikel yang digunakan adalah artikel full-text dengan desain studi Cross sectional. Terdapat 6 artikel yang digunakan dalam penelitian ini yang dianalisis menggunakan aplikasi Review Manager 5.3. Sebanyak 6 artikel dengan studi Cross sectional berasal dari Negara Indonesia, Malaysia dan China  menunjukkan bahwa sikap empati petugas efektif untuk meningkatkan kepuasan pasien pengaruh tersebut secara statistik signifikan (aOR = 2.10; CI 95% = 1.72 hingga 2.56; p<0.001). Kesimpulan: Sikap Empati petugas kesehatan efektif meningkatkan kepuasan pasien.
Influence of Anions on the Corrosion Behavior of 9Cr-1Mo Ferritic Steel in Aqueous Media
Authors: Thinaharan C. , Vanithakumari S.C. , Shankar A. Ravi , Philip John
Published: September 2023

Modified 9Cr-1Mo steel is used as steam generator material in prototype fast breeder reactors, owing to its good corrosion resistance, creep, and thermal conductivity characteristics. In the present study, the corrosion behavior of modified 9Cr-1Mo steel in aqueous environments containing various corrosive ions at potentiodynamic polarization conditions is reported. In chloride-exposed samples, randomly distributed dense shallow pits were seen, whereas mixed anions (, Cl−, and ) in fresh water resulted in deeper pits uniformly distributed on the entire surface. Laser Raman spectroscopy studies revealed the formation of Fe-oxides/hydroxides and Cr(VI) species, except in alkaline solution. A very thin film of only Fe-oxides (Fe3O4, γ-Fe2O3, and α-Fe2O3) was identified in an OH– ion-dominated solution. X-ray photoelectron spectroscopy results confirm the corroded surfaces comprised of Fe, Cr, and Mo-oxides of varying composition and enrichment of Mo-oxides in alkaline solution. Chloride ions present in the corroded layer influenced the pitting corrosion in neutral chloride and fresh water solutions. Field emission scanning electron microscopy images revealed abundant crystalline lepidocrocite with laminar morphology and doughnut-type magnetite together with pits on the samples exposed in neutral chloride and fresh water media.
Colossians and Philemon
Authors: Thompson Marianne Meye
Published: September 2023

Colossians and Philemon have traditionally been overshadowed by other New Testament texts thought to express Pauline theology more clearly. In this notable commentary, however, Marianne Meye Thompson shows how these two epistles provide a unique formulation of the gospel in terms of creation and reconciliation rather than justification by faith. In Colossians she finds an overarching narrative of the Bible’s grand creation-redemption story and an important emphasis on the relationship between creation and Christology, while her exploration of Philemon casts brighter light on the significance of Paul’s familial metaphors for the church and the meaning of new humanity in Christ. Throughout her work on these two epistles, Thompson continually connects her insights to theological concerns, making this volume an excellent addition to the Two Horizons series.
The First Epistle to the Corinthians, Revised Edition
Authors: Fee Gordon D.
Published: September 2023

This landmark commentary, originally published in 1987, has been lauded as the best study available of Paul's theologically rich first letter to the Corinthians. Writing primarily for pastors, teachers, and students, Gordon Fee offers a readable exposition of 1 Corinthians that clearly describes the meaning of Paul's ideas and their larger theological relevance.

Fee's revised edition is based on the improved, updated (2011) edition of the NIV, and it takes into account the considerable scholarship on 1 Corinthians over the past twenty-five years. Fee has also eliminated “chapter and verse” language — totally foreign to Paul's first-century letter — relegating the necessary numbers for “finding things” to parentheses.
Luke
Authors: Spencer F. Scott
Published: September 2023

The story Luke tells in his gospel, says F. Scott Spencer, is “a compelling, complex narrative confession of faith in God. To what degree anyone joins Luke in that faith journey is up to them, but any responsible interpreter must attend considerately to Luke's theological roadmap.”

In this latest addition to the Two Horizons New Testament Commentary series, Spencer integrates close textual analysis of Luke's unfolding narrative with systematic theology, spiritual formation, philosophical inquiry, and psychological research. With section-by-section commentary, Spencer highlights the overriding salvific message that runs through Luke's gospel. Pastors, scholars, and students alike will benefit from Spencer's insight into Luke's theological significance.
The First Epistle of Peter
Authors: Davids Peter H.
Published: September 2023

Peter David's study on I Peter is part of The New International Commentary on the New Testament. Prepared by some of the world's leading scholars, the series provides an exposition of the New Testament books that is thorough and fully abreast of modern scholarship yet faithful to the Scriptures as the infallible Word of God.
The Gospel of Luke
Authors: Green Joel B.
Published: September 2023

This highly original commentary, part of the New International Commentary, is unique for the way it combines concerns with first-century culture in the Roman world with understanding the text of Luke as a wholistic, historical narrative.
The Letter of James
Authors: McKnight Scot
Published: September 2023

Scot McKnight here explains the Letter of James both in its own context and as it may be seen in light of ancient Judaism, the Graeco-Roman world, and emerging earliest Christianity.

From beginning to end, the book is shaped for pastors, teachers, and scholars. McKnight is less interested in shedding new light on James than on providing a commentary for those who want to explain the letter and its significance to congregations and classes.

This commentary is accessible to a broad readership, at once full of insight and of good sense and wit that makes for good reading. The Letter of James is an especially helpful source for consultation as to what James is about.
The Letters to Timothy and Titus
Authors: Yarbrough Robert W.
Published: September 2023

The Pastoral Letters—1 Timothy, 2 Timothy, and Titus—have made an enduring contribution to understanding the role of pastors in the church. With a spirited devotion to the text, Robert Yarbrough helps unlock the meaning of these short but rich letters in this commentary.

In keeping with the character of Pillar New Testament Commentary volumes, The Letters to Timothy and Titus offers a straightforward reading of these texts. Their primary concerns—God, salvation, and the pastoral task—remain central to Yarbrough’s thorough and comprehensive exegesis. Engaging with the best scholarship and resources, Yarbrough shows how these letters are as relevant today as they were to the early Christians.
The Gospel of Matthew
Authors: Wilson Walter T.
Published: September 2023

What was the original purpose of the Gospel of Matthew? For whom was it written? In this magisterial two-volume commentary, Walter Wilson interprets Matthew as a catechetical work that expresses the ideological and institutional concerns of a faction of disaffected Jewish followers of Jesus in the late first century CE. Wilson’s compelling thesis frames Matthew’s Gospel as not only a continuation of the biblical story but also as a didactic narrative intended to shape the commitments and identity of a particular group that saw itself as a beleaguered, dissident minority. Thus, the text clarifies Jesus’s essential Jewish character as the “Son of David” while also portraying him in opposition to prominent religious leaders of his day – most notably the Pharisees – and open to cordial association with non-Jews.

Through meticulous engagement with the Greek text of the Gospel, as well as relevant primary sources and secondary literature, Wilson offers a wealth of insight into the first book of the New Testament. After an introduction exploring the background of the text, its genre and literary features, and its theological orientation, Wilson explicates each passage of the Gospel with thorough commentary on the intended message to first-century readers about topics like morality, liturgy, mission, group discipline, and eschatology. Scholars, students, pastors, and all readers interested in what makes the Gospel of Matthew distinctive among the Synoptics will appreciate and benefit from Wilson’s deep contextualization of the text, informed by his years of studying the New Testament and Christian origins.
The Gospel and Letters of John
Authors: von Wahlde Urban C.
Published: September 2023

This radically new, three-volume commentary by Urban von Wahlde on the Gospel and Letters of John is the most detailed study of the composition of the Johannine literature ever put forth by an American scholar.

Some of the most serious problems involved with interpreting John are due to the complex history of the Gospel's composition. While many scholars overlook the various inconsistencies and conflicting “voices” present in this Gospel, von Wahlde painstakingly examines them, exposing the distinct stages — and literary strata — in the Johannine tradition and showing how each represents a further theological development. His thorough and precise exegesis will lead readers to a fuller understanding of both the Gospel and the Letters in all their richness.

In this second volume, von Wahlde provides a detailed commentary on the Gospel of John. He includes his own translation from the Greek (with material from each edition of the Gospel indicated by typeface) along with detailed notes on individual verses. He also sets forth a developmental commentary that shows the meaning of each passage — and how and why the meaning may have changed throughout the Gospel's development — and he demonstrates how individual passages contribute to the overall structure and "religious thought" of the Gospel at each point in its composition and in its present form.
The Gospel according to Luke
Authors: Edwards James R.
Published: September 2023

In keeping with the Pillar New Testament Commentary’s distinctive character, this volume by James R. Edwards on Luke gives special attention to the Third Gospel’s vocabulary and historical setting, its narrative purpose and unique themes, and its theological significance for the church and believers today.

Though Luke is often thought to have a primarily Gentile focus, Edwards counterbalances that perspective by citing numerous evidences of Luke's overarching interest in depicting Jesus as the fulfillment of God's providential work in the history of Israel, and he even considers the possibility that Luke himself was a Jew. In several excursuses Edwards discusses particular topics, including Luke's infancy narratives, the mission of Jesus as the way of salvation, and Luke's depiction of the universal scope of the gospel.

While fully conversant with all the latest scholarship, Edwards writes in a lively, fluent style that will commend this commentary to ministers, students, scholars, and many other serious Bible readers.
1 Peter
Authors: Green Joel B.
Published: September 2023

Even though the letter of 1 Peter has sometimes been overshadowed by Paul's many New Testament letters, it is nonetheless distinctive for the clarity with which it presents the Christian message. In this volume Joel Green offers a clear paragraph-by-paragraph analysis of 1 Peter and, even more, unpacks the letter's theology in ways that go beyond the typical modern commentary.
Content Page
Authors: . Pafmj
Published: September 2023

contant page
Spectrum of Intestinal Parasitic Infections in Paediatric Population in A Tertiary Care Hospital
Authors: Sadiq Iqra , Mirza Irfan Ali , Khursheed Umer , Irfan Rafia , Sana Fatima , Akhtar Mahtab
Published: September 2023

Objectives: To determine the frequency of parasites detected in stool samples of children with symptoms of parasitic infections.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Microbiology, Armed Forces Institute of Pathology, in collaboration with Paediatrics Department of Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Jul 2020.

Methodology: A Total of 138 stool samples were collected from children who were admitted or presented in the outdoor department and had symptoms of intestinal parasitic infections. Youngsters who had been dewormed within the previous six months or whose samples arrived at the lab more than three hours after the collection were not included. Stool samples were examined visually and by using a saline preparation followed by a method that involved the concentration of formal ether. This was done to determine the different kinds of trophozoites, adult worms, and eggs or cysts that parasites produce.

Results: The study found that intestinal parasites were moderately prevalent (26.81%) among the pediatric population, with Giardia lamblia (54.05%) being the most frequent, followed by Entamoeba histolytica (35.14%) and Ascaris lumbricoides (5.41%).

Conclusion: It is recommended to guarantee the accessibility of purified drinking water to decrease the incidence of parasitic infections within our populace.
Modern possibilities for correcting of severe iron deficiency anemia during pregnancy
Authors: Einysh E. A. , Vaculchik I. O. , Vaculchik L. I. , Lukashenko E. G. , Krautsova N. V. , Kiselyova T. A.
Published: September 2023

An analytical review of literature data on modern methods of treatment of pregnant patients with severe iron deficiency anemia (IDA) was carried out. The authors present their own data on the results of treatment of severe IDA in two pregnant patients who were in the Department of Pregnancy Pathology of the Gomel City Clinical Hospital №3 in October – November 2022. Literature data on the high effectiveness of treatment of pregnant patients with severe IDA by intravenous infusion of iron carboxymaltosate in a dose of 1000 mg . The absence of immediate adverse side effects and complications of pregnancy makes it reasonable to use this drug in the 2nd and 3rd trimesters in the complex treatment of IDA.