bluuebunny/crossref_metadata_2025 huggingface dataset:
Bacteria - Medfly Interactions: a Spatial, Temporal and Functional Study
Authors: Jurkevitch Edouard , Lauzon Carol R. , Yuval Boaz , McCombs Sue D.
Published: March 2022

Our progress overallhas been gratifying. We have been able to characterize the microflora of wild and mass reared flies, determine their mode of transmission, their spatial distribution, and their contribution to the fitness of the fly. In addition we have been able to demonstrate that manipulation of the bacteria residing in the gut of sterile males, significantly improves their reproductive success. These points are expanded below.
Molecular Mechanisms of Sex Determination in Cultured Tilapias
Authors: Hulata Gideon , Kocher Thomas D. , Ron Micha , Seroussi Eyal
Published: March 2022

Tilapias are among the most important aquaculture commodities worldwide. Commercial production of tilapia is based on monosex culture of males. Current methods for producing all-male fingerlings, including hormone treatments and genetic manipulations, are not entirely reliable, in part because of the genetic complexity of sex determination and sexual differentiation in tilapias. The goals of this project are to map QTL and identify genes regulating sex determination in commonly cultured tilapia species, in order to provide a rational basis for designing reliable genetic approaches for producing all-male fingerlings. The original objectives for this research were: 1) to identify the gene underlying the QTL on LG1 through positional cloning and gene expression analysis; 2) to fine map the QTL on LG 3 and 23; and 3) to characterize the patterns of dominance and epistasis among QTL alleles influencing sex determination. The brain aromatase gene Cyp19b, a possible candidate for the genetic or environmental SD, was mapped to LG7 using our F2 mapping population. This region has not been identified before as affecting SD in tilapias. The QTL affecting SD on LG 1 and 23 have been fine-mapped down to 1 and 4 cM, respectively, but the key regulators for SD have not been found yet. Nevertheless, a very strong association with gender was found on LG23 for marker UNH898. Allele 276 was found almost exclusively in males, and we hypothesized that this allele is a male-associated allele (MAA). Mating of males homozygous for MAA with normal females is underway for production of all-male populations. The first progeny reaching size allowing accurate sexing had 43 males and no females. During the course of the project it became apparent that in order to achieve those objectives there is a need to develop genomic infrastructures that were lacking. Efforts have been devoted to the development of genomic resources: a database consisting of nearly 117k ESTs representing 16 tissues from tilapia were obtained; a web tool based on the RepeatMasker software was designed to assist tilapia genomics; collaboration has been established with a sequencing company to sequence the tilapia genome; steps have been taken toward constructing a microarray to enable comparative analysis of the entire transcriptome that is required in order to detect genes that are differentially expressed between genders in early developmental stages. Genomic resources developed will be invaluable for studies of cichlid physiology, evolution and development, and will hopefully lead to identification of the key regulators of SD. Thus, they will have both scientific and agricultural implications in the coming years.
Molecular and in vivo Functions of the Chloroplast Chaperonins
Authors: Azem Abdussalam , Lorimer George , Breiman Adina
Published: March 2022

We present here the final report for our research project entitled "The molecular and in vivo functions of the chloroplast chaperonins”. Over the past few decades, intensive investigation of the bacterial GroELS system has led to a basic understanding of how chaperonins refold denatured proteins. However, the parallel is limited in its relevance to plant chaperonins, since the plant system differs from GroEL in genetic complexity, physiological roles of the chaperonins and precise molecular structure. Due to the importance of plant chaperonins for chloroplast biogenesis and Rubisco assembly, research on this topic will have implications for many vital applicative fields such as crop hardiness and efficiency of plant growth as well as the production of alternative energy sources. In this study, we set out to investigate the structure and function of chloroplast chaperonins from A. thaliana. Most plants harbor multiple genes for chaperonin proteins, making analysis of plant chaperonin systems more complicated than the GroEL-GroES system. We decided to focus on the chaperonins from A. thaliana since the genome of this plant has been well defined and many materials are available which can help facilitate studies using this system. Our proposal put forward a number of goals including cloning, purification, and characterization of the chloroplast cpn60 subunits, antibody preparation, gene expression patterns, in vivo analysis of oligomer composition, preparation and characterization of plant deletion mutants, identification of substrate proteins and biophysical studies. In this report, we describe the progress we have made in understanding the structure and function of chloroplast chaperonins in each of these categories.
Discovery and reconstitution of cross-reactive vaccine targets for H5 and H9 avian influenza
Authors: Gershoni Jonathan M. , Swayne David E. , Pupko Tal , Perk Shimon , Panshin Alexander , Lublin Avishai , Golander Natalia
Published: March 2022

Research objectives: Identification of highly conserved B-cell epitopes common to either H5 or H9 subtypes of AI Reconstruction of conserved epitopes from (1) as recombinantimmunogens, and testing their suitability to be used as universal vaccine components by measuring their binding to Influenza vaccinated sera of birds Vaccination of chickens with reconstituted epitopes and evaluation of successful vaccination, clinical protection and viral replication Development of a platform to investigate the dynamics of immune response towards infection or an epitope based vaccine Estimate our ability to focus the immune response towards an epitope-based vaccine using the tool we have developed in (D) Summary: This study is a multi-disciplinary study of four-way collaboration; The SERPL, USDA, Kimron-Israel, and two groups at TAU with the purpose of evaluating the production and implementation of epitope based vaccines against avian influenza (AI). Systematic analysis of the influenza viral spike led to the production of a highly conserved epitope situated at the hinge of the HA antigen designated “cluster 300” (c300). This epitope consists of a total of 31 residues and was initially expressed as a fusion protein of the Protein 8 major protein of the bacteriophagefd. Two versions of the c300 were produced to correspond to the H5 and H9 antigens respectively as well as scrambled versions that were identical with regard to amino acid composition yet with varied linear sequence (these served as negative controls). The recombinantimmunogens were produced first as phage fusions and then subsequently as fusions with maltose binding protein (MBP) or glutathioneS-transferase (GST). The latter were used to immunize and boost chickens at SERPL and Kimron. Furthermore, vaccinated and control chickens were challenged with concordant influenza strains at Kimron and SEPRL. Polyclonal sera were obtained for further analyses at TAU and computational bioinformatics analyses in collaboration with Prof. Pupko. Moreover, the degree of protection afforded by the vaccination was determined. Unfortunately, no protection could be demonstrated. In parallel to the main theme of the study, the TAU team (Gershoni and Pupko) designed and developed a novel methodology for the systematic analysis of the antibody composition of polyclonal sera (Deep Panning) which is essential for the analyses of the humoral response towards vaccination and challenge. Deep Panning is currently being used to monitor the polyclonal sera derived from the vaccination studies conducted at the SEPRL and Kimron.
LITERASI UANG ELEKTRONIK SEBAGAI PILIHAN GAYA HIDUP MASYARAKAT IBUKOTA DI ERA DIGITAL
Authors: Handayani Retno Dwi Sri , Lubis Mayang Salsabila , Wiranto Sulistyo Anjar
Published: March 2022

Pengguna uang elektronik kini berasal dari berbagai kalangan seperti mahasiswa
dan pekerja yang biasanya mengincar promo dan diskon di dalamnya. Meningkatnya penggunaan, pasti diikuti pula dengan meningkatnya merchant-merchant yang mendukung pembayaran dengan uang elektronik sehingga hal tersebut mempengaruhi gaya hidup masyarakat yang menggunakannya, dan kami pun melakukan penelitian ini. Pendekatan yang digunakan dalam penelitian ini adalah melalui pendekatan kualitatif dengan metode studi kasus. Pengumpulan data dilakukan dengan melakukan wawancara mendalam untuk menggali informasi dari beberapa informan mengenai eksistensi uang elektronik sebagai pilihan gaya hidupnya dilihat dari segi kepercayaan, kenyamanan, fasilitas pelayanan, keamanan, pengetahuan, aktivitas, opini serta minatnya dalam menggunakan uang elektronik. Untuk menguji keabsahan data, digunakanlah teknik triangulasi sumber yaitu dengan menguji data dengan sumber yang berbeda-beda. Dan teknik analisis data yang digunakan adalah analisis model Miles dan Huberman (Prastowo, 2012: 242) yang dapat melalui 4 proses yaitu: pengumpulan data, reduksi data, penyajian data,
dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa uang elektronik sangat dibutuhkan masyarakat untuk memenuhi gaya hidupnya dan kami harap, ini dapat menjadi bahan literasi bagi masyarakat Ibukota tentang uang elektronik sebagai pilihan gaya hidupnya di era digital
Rapid microscopic fractional anisotropy imaging via an optimized linear regression formulation
Authors: Arezza Nico , H. Y. Tse Desmond , Baron Corey A.
Published: March 2022

Microscopic fractional anisotropy (μFA) is a diffusion MRI (dMRI) metric that can quantify water diffusion anisotropy independent of neuron fiber orientation dispersion. However, there are several different techniques to estimate μFA and few have demonstrated full brain imaging capabilities within clinically viable scan times and resolutions. Here, we present an optimized spherical tensor encoding (STE) technique to acquire μFA directly from the 2nd order cumulant expansion of the powder averaged dMRI signal obtained from direct linear regression.
Review of The corruption debates: Left vs. Right—and Does It Matter—in the Americas,
Authors: Silva Patricio
Published: March 2022

The corruption debates: Left vs. Right—and Does It Matter—in the Americas, Stephen D. Morris. Lynne Rienner Publisher, 2021
Corporate Social Responsibility and Tax Aggressiveness
Authors: Pratama Gilang , Widarjo Wahyu
Published: March 2022

This study aims to analyze the effect of corporate social responsibility on tax aggressiveness. Agency theory is used to explain the relationship between corporate social responsibility variables and tax aggressiveness. The relationship between principal and agent has different interests. The agent has more information than the principal, so opportunistic actions may occur by agents through tax aggressiveness; furthermore, agents use corporate social responsibility to hide these opportunistic actions. The research sample used is the annual financial statements of mining companies listed on the Indonesia Stock Exchange in 2013-2020. The results of the analysis of 96 samples show that corporate social responsibility has a negative and significant effect on tax aggressiveness. This means that the higher the company carries out corporate social responsibility activities, the smaller the company is willing to take tax aggressiveness actions. This shows that companies tend to avoid tax aggressiveness and comply more with applicable tax regulations to improve the company's image as obedient taxpayers. Although corporate social responsibility is bound by regulations, companies do not take advantage of it in terms of aggressive tax practices. Furthermore, the company shows a tendency to enforce the government's plan in terms of tax revenue along with the company's long-term goals. This study expands the focus of the literature on developed economies by examining the relationship between corporate social responsibility and corporate tax aggressiveness in an emerging Asian economic setting, namely Indonesia. It is also an empirical study that focuses on mining companies in Indonesia.
Linfoma difuso de células grandes B de nasofaringe: a propósito de un caso
Authors: Pérez Montiel Camilo Andrés , Montes Arcón Pablo Salomón , Redondo De Oro Katherine Tatiana
Published: March 2022

Introducción: los linfomas son neoplasias malignas del sistema linfoide y se clasifican en dos tipos: linfoma de Hodgkin y linfoma no Hodgkin. Los linfomas primarios de nasofaringe son infrecuentes y constituyen aproximadamente el 15% de todos los linfomas de cabeza y cuello. Reporte de caso: se presenta el caso de una paciente de 57 años de edad con antecedente de hipertensión arterial, quien consultó por signos y síntomas asociados a obstrucción nasal. Al examen físico y en las imágenes diagnósticas se evidenció una masa en la nasofaringe, el reporte histopatológico e inmunohistoquímico concluyó un linfoma difuso de células grandes B. Conclusiones: de los linfomas que se presentan en cabeza y cuello, los de origen nasofaríngeo son infrecuentes. El linfoma difuso de células grandes B es el subtipo más común en esta localización y su diagnóstico y tratamiento debe ser oportuno debido a que suelen ser diagnosticados en estadios avanzados y su comportamiento clínico es agresivo.
Implicaciones de la Producción de Aguacate en el Balance Hídrico desde una Perspectiva de los Sistemas de Información Geográfica (SIG), 2011-2019
Authors: Ruíz-Sevilla Gerardo , Ortiz-Paniagua Carlos Francisco
Published: March 2022

A nivel mundial 0.77% del agua dulce disponible es accesible para el ser humano (Harrison y Pearce, 2000), aproximadamente 70% de ésta se destina como insumo para la agricultura (CONAGUA, 2018), misma que responde a la creciente demanda mundial de alimentos. En particular, la producción de un aguacate requiere 227.1 litros de agua (WFN, 2015). La creciente demanda mundial por dicho fruto ha llevado al crecimiento exponencial de la superficie cultivada en Michoacán, los efectos en el balance hídrico ya son notorios. El objetivo del presente, fue estimar los efectos del cultivo de aguacate en el balance hídrico de Tancítaro en Michoacán para el período 2011-2019, mediante el uso de Sistemas de Información Geográfica (SIG) e indicadores de producción, se muestra un déficit hídrico atribuible en parte a la producción de aguacate, dado que 57% de la precipitación pluvial anual equivale a las necesidades de insumo para producción de dicho cultivo.
La resignificación de la literatura migracional latinoamericana actual como respuesta a los populismos europeos
Authors: Basáñez Barrio Endika
Published: March 2022

Throughout the second decade of this century a relevant migrational literature written by Latin American women in Europe has been published, particularly in Spain. This literature depictes the migrational experience of the female writers who, once deterritorialized in the Old Continent, testify about their precariousness and vulnerabilities as subordinated. At the same time ultra parties have emerged all over Europe to blame migrants for all the disasters of their countries so the testimonial corpus may now be re-signified as a response for the dogmas spread by political discourses. The present article, therefore, analyzes from interdisciplinarity the particularities of the current migrational literature written in Europe to highlight how the testimony of the displaced women presents a didactic reading against the xenophobic discourses promulgated by political narratives.
Modelado de estaciones de recarga lenta para vehículos eléctricos mediante software: revisión del estado del arte
Authors: Sáez Yessica , Collado Edwin , Serrano María
Published: March 2022

Los efectos de la contaminación ambiental causada por las emisiones de CO2 de los vehículos de combustión interna son cada vez más notables, por lo cual se ha ido implementado la utilización de vehículos eléctricos con el objetivo de reducir estos agentes nocivos, sin embargo, desde su aparición en el siglo XIX, los vehículos eléctricos han tenido poca autonomía respecto a su batería. La solución propuesta para la resolución de este problema consiste en construir estaciones de recarga en puntos estratégicos como centros comerciales, residencias y estacionamientos de oficina u otros establecimientos; considerando la utilización de una recarga de nivel 1 (lenta) para ofrecer una mayor vida útil a dichas baterías. El objetivo principal de esta revisión literaria es plantear distintos modelados de estaciones de recarga lenta de vehículos eléctricos, proporcionando una gama de softwares encargados de obtener variadas simulaciones como respuesta a distintos procesos. Para la realización de la investigación, se obtuvieron como base tres softwares: MATLAB, LabVIEW y AnyLogic. Los datos planteados por estas herramientas permiten concluir que con la utilización de modelados se logra reducir el costo y duración del proceso de diseño y desarrollo de los distintos sistemas, y además ayuda a visualizar el sistema a una escala computacional y, por ende, reduce el número de defectos.
Modelling and Structuring Narrative Historical Sources with Temporal Context
Authors: Ogawa Jun , Nagasaki Kiyonori , Ohmukai Ikki
Published: March 2022

Creating semantically well-structured data from various historical sources is a challenging task as its contents are quite complicated and less structured. Factoid Prosopography Ontology (FPO), a source-oriented data model for prosopography, tackles this problem and enables the knowledge representation of historical information. However, we highlight two issues that FPO does not sufficiently address. The first issue relates to the temporal expression. While FPO provides a way of attaching date or the date range to historical phenomena, it is based on absolute time information, which is not always given in historical sources. To overcome this, we introduce a way of expressing relative time information by describing a temporal sequence of events mentioned in sources. Second, the more important issue is how to describe the context for each entity mentioned in sources. This context information is not explicitly described in sources but plays an essential role in reading historical sources. For this, we introduced a new concept EntityInContext, which represents ‘an actor in certain context’ as a single Uniform Resource Indicator (URI), and an instance of EntityInContext is defined based on the events’ sequence described earlier. The validity of the model was clarified by creating actual data for Caesar's Bellum Gallicum and attempting a SPARQL search.
Life Cycle Assessment Approach to Evaluation of Environmental Impact Batik Industry
Authors: Iqbal Muhammad Noer , Lestari Safitri Puji , Yosafaat Michael , Mardianta Keke Afrilia , Septiariva Iva Yenis , Suryawan I Wayan Koko
Published: March 2022

Industri batik merupakan salah satu bisnis tekstil yang paling berkembang di Indonesia. Hasil samping dari proses membatik adalah berbagai bentuk limbah, seperti limbah padat dan limbah cair. Pencemaran terutama bersumber dari limbah cair yang berupa zat warna yang dihasilkan sisa bahan pewarna, proses pencucian dan pembilasan kain batik. Pada umumnya limbah industri batik terdiri dari dari sisa mori, ceceran lilin, sisa air pewarnaan, sisa lilin dan air pelorodan. Salah satu cara untuk mengurangi dampak lingkungan dari proses pembuatan batik adalah dengan menggunakan analisis life cycle assessment (LCA). Penelitian ini bertujuan untuk menganalisis dampak lingkungan dari proses pembuatan batik dan input bahan baku yang memiliki dampak lingkungan paling signifikan. Analisis dampak lingkungan dilakukan dengan menginventarisasi input dan output berdasarkan database ecoinvent 3 menggunakan software Simapro 9.1.1. Metode analisis dampak lingkungan dilakukan dengan environmental product declaration (EPD) 2018. Hasil analisis gate-to-gate menunjukkan bahwa dampak lingkungan tertinggi adalah pemanasan global. Sedangkan dari sisi penggunaan bahan baku dan energi, parafin perlu diminimalisir. Penggunaan parafin menyumbang 68,705% dari total dampak lingkungan dari proses pembuatan batik.

 

The batik industry is one of the most developed textile businesses in Indonesia. The by-products of the batik-making process are various forms of waste, such as solid waste and wastewater. Pollution mainly comes from liquid waste in the form of dyes produced by residual dyes, washing and rinsing processes for batik cloth. In general, batik industry waste consists of residual mori, spilled wax, residual staining water, wax residue and pelorodan water. This liquid waste is generated due to the use of synthetic dyes in the batik industry. One way to reduce the environmental impact of the batik-making process is by using a life cycle assessment (LCA) analysis. This study aims to analyze the environmental effects of the batik-making process and the raw material input, which has the most significant environmental impact. Environmental impact assessment is carried out by inventorying inputs and outputs based on the ecoinvent 3 databases with Simapro 9.1.1 software. The environmental impact analysis method is carried out with the 2018 environmental product declaration (EPD). The results of the gate-to-gate analysis show that the highest environmental impact is global warming. Meanwhile, from the use of raw materials and energy, paraffin needs to be minimized. The use of paraffin accounts for 68.705% of the total environmental impact of the batik-making process.
Pemodelan Dinamik Solar Cell dengan Metode Pendekatan Shepherd Modifikasi
Authors: Pratama Wahyu Diski , Khoiriyah Bidayatul , Avenia Bella Octa , Supriyono
Published: March 2022

Pemerintah Indonesia menargetkan konsumsi listrik sebanyak 1.129 kWh/kapita pada tahun 2018. Energi alternatif terbarukan merupakan salah satu solusi dalam mengatasi masalah kenaikan konsumsi listrik yang bertambah setiap tahunnya. Salah satu dari energi alternatif terbarukan adalah solar cell. Solar cell yang digunakan pada mobil listrik sebagai pengisi daya dapat membantu mengurangi konsumsi listrik konvensional. Penelitian ini dilakukan untuk memprediksi kondisi optimum serta cara pengontrolan sebagai sumber energi yang dapat dimanfaatkan. Metode yang dilakukan untuk memprediksi kondisi optimum solar cell adalah dengan pemodelan Shepherd yang tahapannya meliputi pemodelan simulasi solar cell untuk rangkaian, pemodelan simulasi solar cell Shepherd untuk kendaraan listrik (EVs), dan model sirkuit ekuivalen. Kemudian, menyusun pendekatan pemodelan dengan penyusunan persamaan voltase dan arus discharge serta memberikan asumsi-asumsi pada parameter model. Parameter-parameter discharge solar cell berdasarkan data manufaktur yaitu Qfull 1034,32031 mAh/gram, Vfull 17,5177 Volt, Qexp 999,2730931 mAh/gram, Vexp 11,46641134 Volt, Qnom 0,854810174 mAh/gram, Vnom 0 Volt, SOCmin 9,67% dan SOCmax 95,05%. Dari hasil algoritma data simulasi didapatkan parameter-parameter discharge solar cell yaitu E0 12,53704928 Volt, R0 0,012 mΩ, Kdr 0,01 mΩ, Kdv 0,044148043 Volt/mA.h, A 4,9956 Volt, B 2,971366829 (mA.h)-1, SOCmin 9,67% dan SOCmax 95,05%.

The Indonesian government targets electricity consumption of 1.129 kWh/capita in 2018. Renewable energy alternative energy is one solution in overcoming the problem of increasing electricity consumption which increase every year. One of the renewable alternative energy is solar cell. Solar cells used in electric cars as chargers can help reduce conventional electricity consumption. This research was conducted to predict the optimum conditions and how to control it as an energy source that can be utilized. The method used to predict the optimum condition of the solar cell is Shepherd modeling whose stages include solar cell simulation modeling for circuits, Shepherd solar cell simulation modeling for electric vehicle (Evs), and equivalent circuit models. Then, develop a modeling approach by compiling the equations of voltage and discharge current and provide assumptions on the model parameters. The discharge parameters of the solar cell based on manufacturing data are Qfull 1034,32031 mAh/gram, Vfull 17,5177 Volt, Qexp 999,2730931 mAh/gram, Vexp 11,46641134 Volt, Qnom 0,854810174 mAh/gram, Vnom 0 Volt, SOCmin 9,67% and SOCmax 95,05%. From the results of the simulation data algorithm, the parameters of the solar cell discharge are E0 12,53704928 Volt, R0 0,012 mΩ, Kdr 0,01 mΩ, Kdv 0,044148043 Volt/mA.h, A 4,9956 Volt, B 2,971366829 (mA.h)-1, SOCmin 9,67% and SOCmax 95,05%.
The Relationship Between the Social Support Perceived by the Mothers and Their Motherhood Experience
Authors: SEVİMLİ GÜLER Döndü , ÇINAR Nursan
Published: March 2022

Objective: Becoming a mother, is one of the most important developmental events in a woman’s life. This study, by making Turkish validityand reliability study of Being a Mother scale which was developed by Matthey, was conducted methodologically and analytically in order todetermine social support which mothers perceived and motherhood experiences.Methods: The study universe consists of 588 volunteer mothers, who have a child between 0-3 year range, that holds the criteria for thestudy and applied September 2015-March 1016 University Training and Research Hospital. Data was gathered with question form, which wasprepared by researchers, Being a Mother Scale (BaM 13) and Multi-dimensional Perceived Social Support Scale (MDPSSS). Data were evaluatedwith the help of IBM SPSS Statistics 23 and IBM SPSS AMOS 23 statistics programs.Results: It was determined that 45.7% of mothers remain in the 28-34 year range and 47.1% were primary school graduates. It was seen thatthe Being a Mother Scale has good psychometric characteristics. It was determined that the model, which consists of 25 statements with 6factors integrated structure of Being a Mother Scale and Multidimensional Perceived Social Support, generally fits for the research purposes.Conclusions: As a result of the validity and reliability study of the Being a Mother scale, it was seen that it is applicable for Turkish society. Adecrease of satisfaction from motherhood was determined accordingly decreasing social support.
PESAN PERSUASIF “PERIKSA LEHER ANDA” PADA INSTAGRAM @PITATOSCA DAN PERILAKU DETEKSI DINI GANGGUAN TIROID
Authors: Cahyandani Pramesti Ayu , Riyantini Rini , Mahdalena Vina
Published: March 2022

Gangguan tiroid merupakan penyakit yang memiliki gejala umum dan tidak spesifik, sehingga masih banyak masyarakat yang tidak menyadarinya, padahal gangguan tiroid dapat berefek pada komplikasi paska melahirkan. Gangguan tiroid yang tidak diketahui sejak dini beresiko terhadap penyakit jantung, gangguan pada mata, bahkan pengeroposan tulang, sehingga perlu dikomunikasikan kepada masyarakat agar mereka semakin memahami gejala gangguan tiroid. Penelitian ini membuktikan pentingnya pesan persuasif “Periksa Leher Anda” yang disampaikan oleh komunitas Pita Tosca pada instagram @pitatosca agar masyarakat mampu melakukan perilaku deteksi dini gangguan tiroid melalui uji regresi sederhana. Metode penelitian yang digunakan adalah survey eksplanatif terhadap anggota komunitas Pita Tosca dengan teknik  accidental sampling  kepada 107 responden. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang nyata antara pesan persuasif “Periksa Leher Anda” pada instagram @pitatosca terhadap perilaku deteksi dini gangguan tiroid anggota komunitas Pita Tosca, dengan hasil uji hipotesis Ha diterima dan H0 ditolak.
PANDANGAN MEDIA TIONGKOK TERHADAP INDONESIA DALAM MENGHADAPI PANDEMI COVID-19 STUDI KASUS : SCMP DAN XINHUA NEWS
Authors: Nathanael Garcia Krisnando
Published: March 2022

Abstract   This study aims to find out how the Chinese media view Indonesia in dealing with the Covid-19 pandemic. From 2020 to 2021, Indonesia still has not been able to produce significant progress in handling the Covid-19 pandemic. This phenomenon is also in the international spotlight. Two Chinese mass media, South China Morning Post (SCMP) and Xinhua News reported information on the development of handling the Covid-19 pandemic in Indonesia. This study uses qualitative research methods with secondary data derived from journals, news, and other academic texts. Data analysis was carried out using the theories and concepts of communication and global media and mass media. Based on this research, it was found that there are two different views of the Chinese mass media. SCMP reported that the handling of Covid-19 tends to be slow, including traditional treatment in East Kalimantan. On the other hand, Xinhua News said that Indonesia is trying to meet health needs for handling Covid-19. Keywords: Mass Media, China, Indonesia, Covid-19 Abstrak Penelitian ini bertujuan untuk mengetahui bagaimana pandangan media Tiongkok terhadap Indonesia dalam menghadapi pandemi Covid-19. Dari tahun 2020 hingga 2021, Indonesia masih belum dapat menghasilkan perkembangan signifikan dalam penanganan pandemi Covid-19. Fenomena ini juga menjadi sorotan internasional. Dua media massa Tiongkok, South China Morning Post (SCMP) dan Xinhua News memberitakan informasi perkembangan penanganan pandemi Covid-19 di Indonesia. Penelitian ini menggunakan metode penelitian kualitatif dengan data sekunder yang berasal dari jurnal, berita, dan naskah akademik lainnya. Analisis data dilakukan dengan menggunakan teori dan konsep komunikasi dan media global dan media massa. Berdasarkan penelitian ini, ditemukan bahwa terdapat dua pandangan berbeda dari media massa Tiongkok. SCMP memberitakan bahwa penanganan Covid-19 yang cenderung lambat, termasuk adanya pengobatan secara tradisional di Kalimantan Timur. Di lain sisi, Xinhua News menyampaikan bahwa Indonesia berusaha untuk memenuhi kebutuhan kesehatan untuk penanganan Covid-19. Kata kunci: Media Massa, Tiongkok, Indonesia, Covid-19
PERKAWINAN ADAT MELAYU BANGKA SEBAGAI MEDIA KOMUNIKASI TRADISIONAL
Authors: Suryani Suryani , Vidya Riani Galih Jati
Published: March 2022

Abstrak. Perkawinan campuran antara dua budaya yang berbeda yakni budaya China dengan budaya Melayu, membentuk budaya dan tradisi baru. Di mana budaya memberikan  identitas pada setiap individu, hubungan keduanya penting untuk dipahami dalam menyampaikan pesan. Dalam perkawinan melayu Bangka terdapat simbol-simbol  komunikasi  budaya yang tersirat makna di dalamnya. Dengan menggunakan analisis etnometodologi melalui penafsiran-penafsiran makna dari setiap narasumber dengan tujuan untuk mendeskripsikan makna dari setiap prosesi dan perlengkapan dalam adat perkawinan Bangka sebagai media komunikasi tradisional masyarakat Bangka. Berdasarkan temuan hasil penelitian, ditemukan bahwa tradisi perkawinan adat Melayu Bangka masih dipelihara oleh masyarakat  Bangka meski dalam prakteknya terjadi pengeseran dan pengembangan tapi meski begitu tidak mengurangi nilai pesan yang ingin disampaikan dari setiap penggunaaan simbol-simbol dalam upacara ritual perkawinan adat Melayu Bangka. Dari setiap simbol prosesi adat perkawinan melayu Bangka melalui delapan tahap tersebut  mengandung pesan yang menyiratkan bagi pasangan tersebut dalam memasuki rumah tangga agar menjadi keluarga yang sakinah dan terhindar dari hal-hal yang tidak diinginkan dan  pada saat menjalani kehidupan rumah tangga baik sebelum pelaksanaan atau pun sesudah pelaksanaan perkawinan. Prosesi itu juga mengajarkan nilai-nilai penting dalam interaksi sosial dalam subsistem baru di masyarakat.Kata Kunci: perkawinan, adat, tradisi, media, tradisional
PELATIHAN PEMBUATAN ECO ENZYME DARI LIMBAH ORGANIK RUMAH TANGGA DI DASA WISMA SUKUN
Authors: Murdiana Happy Elda , Yuhara Novena Adi , Rahmavika Tabita , Danila Devia
Published: March 2022

Garbage is a never-ending problem for cities in Indonesia. Garbage hoarding is always increasing every year. The amount of waste is increasing along with the increase in population and consumption patterns. Even though the garbage capacity in DIY increases, the increase in the volume of waste also increases so that independent waste management to reduce waste is an effective way of reducing waste problems. Eco enzyme is the result of fermentation from household organic waste with the composition of water: organic waste (raw fruit peels and fresh vegetable waste): molasses = 10:3:1 which has many functions. The eco enzyme making training begins with counseling then assistance until harvest. Eco enzyme can be harvested after a fermentation process for 3 months by storing it in an airtight plastic container. The number of Dasa Wisma Sukun conducts eco enzyme making activities with the assistance of local eco enzyme volunteers until harvesting and can use the results for many household needs. This community service activity is very beneficial for many people.

Sampah merupakan masalah tak kunjung selesai bagi kota kota di Indonesia, penimbunan sampah setiap tahunnya selalu meningkat. Jumlah sampah semakin meningkat seiring dengan peningkatan jumlah penduduk dan pola konsumsi masyarakat. Walaupun daya tampung sampah di DIY bertambah, tetapi peningkatan volume sampah juga bertambah lebih banyak sehingga pengelolaan sampah mandiri untuk mengurangi sampah merupakan cara efektif mengurangi masalah sampah. Eco enzyme merupakan hasil fermentasi dari sampah organik rumahtangga dengan komposisi air: sampah organik (kulit buah mentah dan sampah sayur segar) : molase = 10:3:1 yang mempunyai banyak fungsi. Pelatihan pembuatan eco enzyme ini diawali dengan penyuluhan kemudian pendampingan hingga panen. Eco enzyme dapat dipanen setelah proses fermentasi selama 3 bulan dengan penyimpanan dalam wadah plastik kedap udara. Ibu ibu dasa wisma sukun melakukan kegiatan pembuatan eco enzyme dengan pendampingan relawan eco enzyme nusantara hingga panen dan dapat memanfaatkan hasilnya untuk banyak keperluan rumah tangga. Kegiatan pengabdian masyarakat ini sangat bermanfaat bagi banyak orang.
PENINGKATAN EKONOMI ANGGOTA KOMUNITAS USAHA KOPERASI CREDIT UNION HATI AMBOINA MELALUI PENDIDIKAN DAN PELATIHAN LITERASI KEUANGAN DAN PEMBUKUAN
Authors: Esomar Maria , Arifin Hasmia Melati
Published: March 2022

Maluku province has a financial literacy rate of 36.48%, still below the national index. (OJK, 2019). Cooperatives are expected to have an important role in assisting the government in terms of financial inclusion and literacy. The challenges and problems faced by partners are bad credit problems. Bad loans are caused, among others, due to the lack of understanding and ability of members in managing personal and business finances. The purpose of this activity can help members to have financial plans, plan future expenses, and have savings and also be able to manage their business finances. The procedure for this empowerment activity includes: 1) Coordination with partners regarding the preparation of activity schedules; 2) Preparation of training and material development; 3) Counseling on financial literacy and business bookkeeping; 4) Training on the use of financial instruments and excel applications for business bookkeeping; 5) Assistance and evaluation of the activities carried out. The results obtained are increased understanding of business group community members about financial literacy and bookkeeping, members are able to fill in monthly budget instruments and are able to understand simple bookkeeping and the management of the CU Hati Amboina Cooperative able to use excel bookkeeping applications for further socialization to members of other business groups.

Provinsi Maluku memiliki tingkat literasi keuangan 36,48% masih dibawah indeks nasional. (OJK, 2019). Koperasi diharapkan memiliki peran penting dalam membantu pemerintah dari sisi inklusi dan literasi keuangan. Tantangan dan permasalahan yang dihadapi mitra yaitu masalah kredit macet. Kredit macet diakibatkan antara lain karena kurangnya pemahaman dan kemampuan anggota dalam mengelola keuangan pribadi dan usaha. Tujuan kegiatan ini dapat membantu anggota untuk mempunyai rencana keuangan, merencanakan pengeluaran masa depan, dan memiliki tabungan dan juga mampu menata keuangan usaha mereka, Prosedur kegiatan pemberdayaan ini meliputi: 1) Koordinasi dengan mitra terkait penyusunan jadwal kegiatan; 2) Persiapan pelatihan dan pengembangan materi; 3) Penyuluhan tentang literasi keuangan dan pembukuan usaha; 4) Pelatihan penggunaan instrumen keuangan dan aplikasi excel untuk pembukuan usaha; 5) Pendampingan dan evaluasi terhadap kegiatan yang  dilaksanakan. Hasil yang diperoleh yaitu meningkatnya pemahaman anggota komunitas kelompok usaha tentang literasi keuangan dan pembukuan, anggota mampu mengisi instrumen anggaran belanja bulanan dan mampu memahami pembukuan sederhana dan manajemen Koperasi CU Hati Amboina mampu menggunakan aplikasi pembukuan excel untuk seterusnya disosialisasikan kepada anggota kelompok usaha yang lain.
BIDIK LAHAN SEMPIT DESA CILEBUT JADI INDAH PRODUKTIF MELALUI PEMANFAATAN TEKNOLOGI VERTIKULTUR HIDROPONIK
Authors: Sara Dem Vi , Rusyana Enang , Rubyasih Arina , Wijayanti Sukma Wahyu
Published: March 2022

Lahan pertanian terutama di wilayah perkotaan dan pinggiran kota, saat ini banyak yang beralih fungsi menjadi daerah pemukiman. Desa Cilebut Barat yang berada di pinggiran kota Bogor Kabupaten Bogor pun tak luput dari imbas pesat dan masifnya urbanisasi. Wilayah ini mengalami alih fungsi lahan yang tak terbendung dari degradasi lahan pertanian menjadi pemukiman. Daerah perumahan yang dibangun, dipaksakan untuk menampung lonjakan pendatang, sehingga area terbuka untuk luasan tanaman dan serapan air hujan semakin sempit. Betonisasi jalan komplek menyebabkan desa Cilebut Barat sering mengalami banjir saat musim hujan dan kekeringan saat musim kemarau. Suasana lingkungan perumahan terkesan gersang dan tidak segar karena sangat kurangnya area penghijauan. Data desa menunjukkan bahwa sebagian besar warga desa adalah pensiunan pegawai, ibu rumah tangga, dan profesi lepas lain yang masih kesulitan memenuhi kebutuhan primer hidupnya. Mereka sangat mengidamkan lingkungan yang asri dan produktif, tetapi terkendala dengan pengetahuan, biaya dan lahan yang sempit terbatas. Tim Pengabdian kepada Masyarakat (PkM) Universitas Terbuka Bogor tertantang untuk membantu memberi alternatif solusi menciptakan lingkungan yang asri, sekaligus mengembangkan kegiatan berestetika, sehat, dan produktif. Program yang ditawarkan adalah edukasi, pendampingan pelatihan, dan praktik memanfaatkan teknologi vertikultur hidroponik pada lahan sempit pekarangan. Vertikultur hidroponik adalah sistem tanam dengan media air di dalam wadah/paralon yang disusun/dirakit secara vertikal atau bertingkat pada lahan terbatas. Tanaman yang direkomendasikan adalah tanaman pangan sayuran karena dapat dijadikan sebagai bagian dari gaya hidup (life style) dalam memenuhi kebutuhan pangan keluarga. Kegiatan dilaksanakan di lingkungan RT 07/RW 09 pada bulan September-Oktober 2020 dengan peserta sejumlah 48 orang warga desa. Kebermanfaatan program terlihat dari peningkatan pengetahuan, keterampilan, aktivitas sosial  kebersamaan warga desa dalam menciptakan lingkungan hijau, indah, kreatif yang berpotensi menopang kehidupan ekonomi sehari-hari.
A criatividade distribuída dentro de um círculo colaborativo na preparação de uma estreia
Authors: Leandro Sofia , Santos Bruno
Published: March 2022

Este artigo discute o conceito de criatividade distribuída (CLARKE; DOFFMAN, 2017) e suas interseções com a teoria dos círculos colaborativos de Michael Farrell (2001), apresentando um exemplo de colaboração entre o Duo Sofia Leandro e Bruno Santos com o compositor Harry Crowl. São apresentados exemplos de aspectos decorrentes dos processos que levaram à tomada de decisões criativas desde a composição até à estreia do Concerto nº4, para violino e percussão, em forma de via-crucis sobre o nome de Marielle Franco, em novembro de 2019. Essa colaboração favoreceu a ampliação das interações sonoras entre o violino e os diferentes instrumentos de percussão, bem como do discurso simbólico inerente à forma da peça e à dedicatória. Os exemplos centram-se em questões relacionadas com a instrumentação, com a exploração de timbres e técnicas expandidas, com a gestão do tempo e com a configuração de palco.
Impact of Preanalytical and Analytical Methods on Cell-Free DNA Diagnostics
Authors: Krasic Jure , Abramovic Irena , Vrtaric Alen , Nikolac Gabaj Nora , Kralik-Oguic Sasa , Katusic Bojanac Ana , Jezek Davor , Sincic Nino
Published: March 2022

Graphical Abstract

Depiction of the experimental design.
The User Experience Design Program: Applying Situated and Embodied Cognition Together With Reflective Teaching
Authors: Alenljung Beatrice , Nalin Kajsa , Rambusch Jana
Published: March 2022

The education of students to become competent user experience designers is a delicate matter as students need to obtain a multitude of knowledge, skills, and judgmental abilities. In this paper, our effort to manage this multiplicity in a bachelor's program in user experience design is shared along with our experiences and teaching practices influenced by theories of situated and embodied cognition together with reflective teaching. The program was followed up through interviews with eight alumni and a company representative that employs user experience designers. The results show that the program overall works well, although some of the identified issues need to be addressed in the future. The interpretation is that our program curricula and teaching practices are fruitful, which hopefully can contribute to thoughts and discussions for other teachers in the field of user experience design and human-computer interaction.
Comparative Safety and Efficacy of Eight Antithrombotic Regimens for Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
Authors: Liang Bo , Zhu Yong-Chun , Gu Ning
Published: March 2022

Background

Antithrombotic therapy for patients with atrial fibrillation undergoing percutaneous coronary intervention is facing major treatment problems in clinical practice.

Methods

We firstly conducted a Bayesian network meta-analysis to study the safety and efficacy of different antithrombotic regimens. Only randomized controlled trials from PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Embase, and China National Knowledge Infrastructure were included in our study. The Bayesian random-effects model was used in this study. The primary safety and efficacy outcomes were major bleeding according to the criteria of Thrombolysis In Myocardial Infarction (TIMI) and trial-defined major adverse cardiovascular events, respectively. The secondary safety outcomes were combined TIMI major and minor bleeding, trial-defined primary bleeding events, and intracranial hemorrhage. The secondary efficacy outcomes were all-cause or cardiovascular mortality, myocardial infarction, stroke, stent thrombosis, and hospitalization.

Results

Total of 11,532 patients from the five randomized controlled trials were analyzed, of whom 8,426 were male. Compared with vitamin K antagonist (VKA) plus P2Y12 inhibitor, the odds ratios (95% credible intervals) for TIMI major bleeding were 1.70 (0.77–3.80) for VKA plus dual antiplatelet therapy (DAPT), 1.20 (0.30–4.60) for rivaroxaban plus P2Y12 inhibitor, 1.00 (0.25–3.90) for rivaroxaban plus DAPT, 0.76 (0.21–2.80) for dabigatran plus P2Y12 inhibitor, 0.71 (0.25–2.10) for apixaban plus P2Y12 inhibitor, 1.40 (0.52–3.80) for apixaban plus DAPT, and 1.00 (0.27–4.00) for edoxaban plus P2Y12 inhibitor. For trial-defined major adverse cardiovascular events, compared with VKA plus P2Y12 inhibitor, the odds ratios (95% credible intervals) were 1.10 (0.61–2.00) for VKA plus DAPT, 1.20 (0.45–3.70) for rivaroxaban plus P2Y12 inhibitor, 1.10 (0.38–3.20) for rivaroxaban plus DAPT, 1.10 (0.43–3.10) for dabigatran plus P2Y12 inhibitor, 1.00 (0.47–2.20) for apixaban plus P2Y12 inhibitor, 0.99 (0.46–2.20) for apixaban plus DAPT, and 1.20 (0.43–3.40) for edoxaban plus P2Y12 inhibitor. Apixaban plus P2Y12 inhibitor was the highest-ranking of safety outcomes and VKA plus P2Y12 inhibitor was the highest-ranking of efficacy outcomes other than trial-defined major adverse cardiovascular events.

Conclusion

Apixaban plus P2Y12 inhibitor seems to be linked with fewer bleeding complications while retaining antithrombotic efficacy. Moreover, for most efficacy indicators, the ranking of VKA plus P2Y12 inhibitor is still very high.

Systematic Review Registration

[www.crd.york.ac.uk/prospero/], identifier [CRD42020149894].
An Integrated AMPSO-CLSTM Model for Photovoltaic Power Generation Prediction
Authors: Yu Shiwei , Han Ruilian , Zheng Yuxuan , Gong Chengzhu
Published: March 2022

To address the challenges of volatile and intermittent nature in photovoltaic power (PV) generation forecasting, a new convolutional long short-term memory network (CLSTM) prediction model optimized by adaptive mutation particle swarm optimization (AMPSO) is proposed. In this model, the local sensing ability of the convolutional kernels in the CNN is used to extract high-dimensional features from the variable influential factors of PV power generation, and a mapping between time series data and PV is established by the memory ability of the gate control unit in LSTM. The AMPSO algorithm is introduced to optimize the network structure and weights of CLSTM simultaneously. The performance of the model is verified by two different two data sets. The results show that compared with that of the CLSTM, Auto-LSTM, LSTM and recurrent neural network models, the root mean square error (RMSE) of the AMPSO-CLSTM model decreases by 1.92–6.53% and 6.23–31.10%, the mean absolute error (MAE) decreases by 6.92–16.87% and 11.71–48.84%, and the mean absolute percentage error (MAPE) decreases by 13.24–31.75% and 12.22–49.00%, respectively. Compared with those of the CLSTM model, the number of channels in the convolutional layer of the AMPSO-CLSTM is reduced by 51.76–71.09% and 61.72–86.72%, respectively, and the number of hidden neurons in LSTM is reduced by 32–60% and 53–84%, respectively.
MDN1 Mutation Is Associated With High Tumor Mutation Burden and Unfavorable Prognosis in Breast Cancer
Authors: Hao Shuai , Huang Miao , Xu Xiaofan , Wang Xulin , Huo Liqun , Wang Lu , Gu Jun
Published: March 2022

Background: Breast cancer (BRCA) is the most common cancer worldwide and a serious threat to human health. MDN1 mutations have been observed in several cancers. However, the associations of MDN1 mutation with tumor mutation burden (TMB) and prognosis of BRCA have not been investigated.

Methods: Genomic, transcriptomic, and clinical data of 973 patients with BRCA from The Cancer Genome Atlas (TCGA) database were analyzed. The clinical attributes of BRCA based on the MDN1 mutation status were assessed by comparing TMB and tumor infiltrating immune cells. Gene ontology analysis and gene set enrichment analysis (GSEA) were conducted to identify the key signaling pathways associated with MDN1 mutation. Moreover, univariate and multivariate Cox regression analyses were performed to assess the association between prognostic factors and survival outcomes. Finally, nomograms were used to determine the predictive value of MDN1 mutation on clinical outcomes in patients with BRCA.

Results: MDN1 was found to have a relatively high mutation rate (2.77%). Compared to the MDN1 wild-type patients, the TMB value was significantly higher in MDN1 mutant patients (p < 0.001). Prognostic analysis revealed that MDN1 mutant patients had a worse survival probability than MDN1 wild-type patients (hazard ratio = 2.91; 95% CI:1.07–7.92; p = 0.036). GSEA revealed samples with MDN1 mutation enriched in retinol metabolism, drug metabolism cytochrome P450, glucuronidation, miscellaneous transport, and binding event pathways.

Conclusion: MDN1 mutation was found to be associated with high TMB and inferior prognosis, suggesting that MDN1 mutation may play a potential role in prognosis prediction and immunotherapy guidance in BRCA.