bluuebunny/crossref_metadata_2025 huggingface dataset:
Peningkatan Kemampuan Pemecahan Masalah Matematis Siswa Kelas VIII SMP Parulian 1 Medan Melalui Model Pembelajaran Interaktif Setting Kooperatif
Authors: Harianja Widya , Panjaitan Asmin
Published: June 2022

Penelitian ini bertujuan untuk (1) Mengetahui apakah peningkatan kemampuan pemecahan masalah matematis siswa yang mendapatkan pembelajaran dengan model Pembelajaran Interaktif Setting Kooperatif (PISK) lebih baik dari peningkatan kemampuan pemecahan masalah matematis siswa yang belajar melalui pembelajaran biasa, (2) Mendeskripsikan kesalahan jawaban siswa dalam menyelesaikan soal kemampuan pemecahan masalah. Penelitian ini adalah kuasi eksperimen yang menerapkan dua pembelajaran yaitu model Pembelajaran Interaktif Setting Kooperatif (PISK) dan pembelajaran biasa. Populasi pada penelitian ini adalah seluruh siswa kelas VIII SMP Parulian 1 Medan. Pengambilan sampel dilakukan secara nonprobability sampling, dan diperoleh dua kelas sebagai sampel penelitian. Instrumen penelitian yang digunakan adalah pre-test dan post-test kemampuan pemecahan masalah matematis. Analisis data dilakukan dengan menggunakan uji analisis varians satu arah (One Way Anova) berdasarkan n-gain kedua kelas. Hasil penelitian menunjukkan bahwa (1) Peningkatan kemampuan pemecahan matematis siswa yang mendapatkan model Pembelajaran Interaktif Setting Kooperatif (PISK) lebih baik dari siswa yang mendapatkan pembelajaran biasa, (2) Kesalahan-kesalahan yang dilakukan oleh siswa ketika mengerjakan soal-soal yang berkaitan dengan kemampuan pemecahan masalah matematis adalah kesalahan konseptual, kesalahan prosedural, dan kesalahan teknik
Побудова моделей для прогнозування часових рядів застосовуючи мережі довгострокової пам'яті
Authors: Бойко Н. , Качмарик В.
Published: June 2022

Дослідження присвячено комплексному вивченню мереж довгої короткочасної пам’яті (ДКЧП). Дана архітектура є видом рекурентних нейронних мереж (РНМ), у яких з’єднання між вузлами утворюють граф, орієнтований у часі. У дослідженні проводиться огляд будови та роботи ДКЧП. Також здійснюється аналіз матеріалів і методів. У статті проводяться експерименти: будуються різні моделі для передбачення часових рядів. Аналізуються отримані результати дослідження. У цьому дослідженні будуть розглянуті цінність ДКЧП з практичної сторони у плані застосування, в залежності від виду вхідних даних, а також з теоретичної сторони, яка базуватиметься на розумінні будови блоку ДКЧП.
Моделі багатофакторного прогнозування
Authors: Кондрук Н. Е.
Published: June 2022

Дане дослідження є розвитком напрямку прикладного аналізу даних. Він відіграє важливу роль у виявленні значущої інформації в наборах даних, яка допомагає приймати обґрунтовані рішення в різних сферах людської діяльності. Наведено інформаційні технології багатофакторного прогнозування, які базуються на моделях MLR та DR і є частиною класичного машинного навчання. Розроблена інформаційно-аналітична система на мові програмування Python та бібліотеки scikit-learn, що реалізує описаний підхід. В якості апробаційної моделі обрана актуальна задача прогнозування ВВП України за показниками: індекс інфляції, чисельність населення, офіційний курс долара, рівень безробіття у відсотках та міграційний приріст. Навчальна вибірка містила 16 спостережень. В ході експериментального дослідження кращою виявилось модель дерева регресії із показником коефіцієнту детермінації 99% та середньої абсолютної відсоткової похибки 6%. Дані індекси якості моделі вказують на її високу точність. Перспективні дослідження полягають у розвитку підходу прикладного аналізу даних для розв'язання різних видів прикладних задач.
Навколо сталої Ейлера
Authors: Качайкін М. В.
Published: June 2022

За аналогією зі сталою Ейлера побудована однопараметрична сім’я сталиx, яка визначається як границя різниці послідовності часткових сум узагальненого гармонічного ряду та відповідного інтеграла залежного від параметра. Доведена нескінченна диференційовність по параметру на додатній півoсі, виявлена розривність в нулі та знайдена границя при прямуванні параметра до нескінченності.
Про диференціально-первинні ідеали нетерових напівкілець
Authors: Мельник І. О.
Published: June 2022

Ця стаття присвячена дослідженню поняття диференціально-первинного ідеалу в диференціальному комутативному напівкільці (напівкільці разом із заданому на ньому диференціюванням) та його зв'язками з поняттями квазіпервинного ідеалу та примарного ідеалу. Поняття диференціювання напівкільця традиційно визначають як адитивне відображення, яке задовольняє правило Лейбніца, тобто відображення δ: R → R називають диференціюванням напівкільця R, якщо δ (a + b)= δ (a) + δ (b) і δ (ab) = δ (a)b + aδ (b) для будь-яких a, b ∈ R.
Диференціальний ідеал P напівкільця R називають диференціально-первинним ідеалом, якщо для будь-яких a, b ∈ R, k ∈ ℕ0, з ab(k) ∈ P випливає, що a ∈ P або b ∈ P. Доведено, що ідеал P напівкільця R є диференціально-первинним тоді і тільки тоді, коли для ідеалів I та J напівкільця R з включення IJ ⊆ P випливає, що I ⊆ P або J ⊆ P. Квазіпервинний ідеал напівкільця ━ це диференціальний ідеал, максимальний серед диференціальних ідеалів, що мають порожній перетин з деякою мультиплікативно-замкненою підмножиною даного напівкільця.
У цій статті досліджуються деякі властивості диференціально-первинних ідеалів, зокрема таких ідеалів в диференціальних нетерових напівкільцях.
Стаття складається з двох основних частин. У першій частині встановлено деякі властивості диференціально-первинних ідеалів та подано приклади таких ідеалів. У другій частині статті автор досліджує зв'язки, що існують між поняттями квазіпервинний, примарний ідеал та диференціально-первинний ідеал в нетерових диференціальних напівкільцях. Встановлено, що в диференціальному нетеровому напівкільці R диференціальний ідеал I напівкільця R є диференціально-первинним ідеалом тоді і тільки тоді, коли I є квазіпервинний ідеал.
Paisaje fluvial y mercado de suelo urbano. Análisis comparativo en dos arroyos de la ciudad de La Plata
Authors: Rotger Daniela Vanesa
Published: June 2022

El objetivo del presente artículo es analizar la influencia del paisaje fluvial en el mercado de suelo de la ciudad de La Plata. Metodológicamente se desarrolla un trabajo de carácter cuali-cuantitativo, que se estructura sobre la base de un relevamiento de precios realizado sobre dos cursos de agua situados en la periferia norte de la ciudad: el arroyo del Gato y el arroyo Rodríguez. Este estudio ha comparado no sólo la estructura de valores de suelo en ambos arroyos, sino también las diferencias entre lotes linderos al curso y aledaños. Los resultados exponen la incidencia del paisaje del agua en el mercado de suelo urbano, y las variaciones de los precios en distintas zonas del curso, así como entre ambos casos estudiados, teniendo en cuenta además la ponderación paisajística que adquiere el arroyo en algunos barrios.
Evaluation of environmental effect of pump shoes in terms of manufacturing process
Authors: ZHANG Chi , LI Leiya , GAIDĂU Carmen , ZHOU Jin
Published: June 2022

China is the largest footwear producing country, as well as the largest country producing the footwear manufacturing waste. In order to achieve sustainable development in the footwear industry, we should pay attention to their environmental effect seriously. Therefore, by applying life-cycle assessment (LCA) protocol, we aimed to explore the effect of the manufacturing process on the environment of a classical style of pump shoes. Following guidelines of ISO 14010, we first determined the objective and the scope of this study; then, we collected input and output data from the shoe producing line of a shoe-making enterprise in Wenzhou, China; afterwards, we applied eFootprint software for LCA modeling; finally, we chose three LCA indicators for further analysis: Global Warming Potential (GWP, kg CO2 eq), Primary Energy Demand (PED, MJ) and Abiotic Depletion Potential (ADP, kg Sb eq). Our results show that by producing one pair of pump shoes, the manufacturing process will emit 11.427 Kg CO2 eq in terms of GWP, 232.621MJ in PED and 6.291×10-5Kg sb eq in ADP. Hence, by multiplying the number of shoes produced in China, negative environmental influences from shoe making industry were also dramatic. According to further contribution rate of all process, we found that materials such as the water-based binder and the plastic last used in manufacturing process accounted for the major reason. Overall, while considering the environmental effects from the shoe manufacturing process, we shall not ignore the environmental impact whilst producing the binder and the last. Moreover, by reducing binder usage or updating the shoe making technology, and recycling the last can be an efficient way to reduce the environmental effects from the shoe making industry.
The use of non-chrome mineral tanning materials as a preferable environmentally friendly tanning material
Authors: ANGGRIYANI Emiliana , RACHMAWATI Laili , ADETYA Nais Pinta
Published: June 2022

Mineral chrome tanning agent is the most widely used tanning agent for various types of leather articles, given its various advantages. Besides its many advantages, there is a negative side to chrome tanneries, namely the presence of waste disposal that is harmful to the environment. Therefore, this study aims to determine the quality of mineral tanning materials other than chrome (aluminium and titanium) as a substitute for leather tanning (free of chrome). The research raw materials were 12 pieces of pickled goatskin. The chemicals used are aluminium tanning agent (Novaltan Al), titanium tanning agent, salt (NaCl), Peramit MLN, Derminol OCS, MgO, NaHCO3, BCG indicator, Rellugan GT 50, Tanigan PAK, Lipoderm Liquor SAF, Dermagen GPA, Derminol SPE, Derminol NLM, Acid dyestuff, formic acid, Sincal DR and anti-fungal. The method used is to carry out the tanning process using aluminium tanning agents with levels of 2%, 4%, and 6% Al2O3, continued the combination between aluminium and titanium tanning agent. The results obtained were analyzed for the cross-sectional and content of the leather using the EDX method, a shrinkage temperature (Ts) test, and physical quality of crust skin. The results showed that the higher the Al2O3 content, the more Al content in the leather, but the lower the wrinkle temperature of the leather. Meanwhile, the longer the processing time, the aluminium content in the skin increases. The use of aluminium and titanium tanning agent can improve the physical quality of the skin, both in terms of tensile strength and skin softness. The conclusion that can be drawn is the use of 2% free of chrome (aluminium) tanning material can produce Ts of 71°C. The physical quality of the crust skin from aluminium and titanium mineral tanning agents is better than the single-use of aluminium.
Study on the relationship between the toe-out gait and foot hallux valgus in the elderly Chinese
Authors: LUO Xiang-Dong , ZHANG Yi-Nuo , XUE Chao-Hua , YUE Zong-Min
Published: June 2022

The study selects 50 senior people at the age of more than 60 and 30 young people at the age of 18-26 as test group and control group respectively, including people with mild foot disease, such as flat feet, pes cavus and hallux valgus. Questionnaire survey of effective data volume and observation are used to understand common problems of the foot in the elderly, collect shape photos of the foot in senior people, and subjectively analyze their foot shape and gait characteristics. Footscan plate plantar pressure test system and Kistler 3D force platform are used to objectively analyze plantar pressure distribution and gait characteristics of subjects. According to study results: Toe-out gait causes the plantar pressure to move to the forefoot, therefore, the forefoot is the part with the highest risk of injury of foot in toe-out gait, especially the first toe, causing hallux valgus and various foot problems. The toe-out gait causes increase of gait cycle, slow walking speed, poor buffer effect, and may bring pain in feet and lower extremities, thus affecting the dynamic characteristics of the entire lower limb.
The improved approach to the development of parameters for the inner shape of military boots
Authors: CHERTENKO Liliia , KERNESH Viktoriia , PERVAIA Nataliia , LYPSKYI Tymofii
Published: June 2022

In the work, anthropometric studies of the feet were performed by means of 3D scanning. The results of scanning have been used for two main purposes. Firstly, the features and morphological structure of the feet of young men aged 20-30 were studied, who are the representatives of the Ukrainian population that are subject to mobilization into the ranks of the Armed Forces. Apart from this, the quantitative distribution of the main morphological features of the feet of the sample population was analyzed. During measurements, it was noticed that a large number of men had hypertrophy of the heads of the 1st and 5th metatarsal bones. In order to rationalize the range of lasts with different sizes and fullness, while trying to fully satisfy the requirements of compliance with the anthropometric parameters of the feet of consumers, the parameters of the feet with the hypertrophy of the heads of the 1st and 5th metatarsal bones must be taken into account in the lasts with increased width. Furthermore, the results of scanning constitute the basis for calculating and developing basic parameters of lasts. For this, the work suggested the method of designing a last shape based on such types of input data as a digital foot model, dimensional foot parameters, and a foot print obtained as a result of mass 3D scanning of the feet.
Technology development of liquid finishing of chrome-tanned goatskin
Authors: PERVAIA Nataliia , ANDREYEVA Olga
Published: June 2022

There has been developed resource-saving environmentally friendly technology for producing chrome-tanned goatskin for shoe upper using new synthetic materials, which involves neutralization in the presence of Politan BN – syntan-neutralizer based on naphthalene sulfonic acid (Codyeco S.p.a., Italy) in the amount of 3.6% (in terms of dry residue), fatliquoring with a mixture of drugs Sulphirol C – a fatliquoring drug based on sulfonated fish oil, resistant to electrolytes (Smit & Zoon, Netherlands) and SMX 473 – a semi-synthetic composition based on sulfonated and sulphated fats (Shebekinsky industrial chemistry, Russia) in the ratio of 70:30 with a total fat consumption of 5.0% (in terms of 100% fat), retanning-filling Retanal LMV 100 – retanning agent based on melamine (Cromogenia Units, Spain) in the amount of 4.5% (in terms of dry residue). This allows to expand the range of chemical materials for liquid finishing and increase production efficiency (conditional economic benefit is UAH 9.22 per 1 m2 of finished products due to more rational use of raw and material resources), while increasing the uniformity of distribution of tensile strength in different areas of the skin, strength of surface, elongation at strain 10 MPa in 1.2-1.4 times, the skin yield by area increases by 1.8%, and its grade – by 0.7%; improve the physical, mechanical and hygienic properties of the skin; reduce the harmful load on the environment. The technology has passed production tests at PJSC “Chinbar” (Kyiv, Ukraine) and is ready for implementation at tanneries.
Designing of the shoe upper using modern information and computer technologies
Authors: SKIDAN Vladyslava , YEFIMCHUK Halyna , MYTELSKA Olena , PAVLENKO Volodymyr , SMYKALO Kateryna
Published: June 2022

The article presents the process of designing the details of shoe upper for schoolchildren using the numerical characteristics of the feet and modern computer technology. A software module for processing the obtained data in the MathCad Education program has been developed, which allows to create parametric models of the foot and longitudinal-vertical section of the internal shape with a deviation of not more than 5%. It is established that developing parametric aspects of shoe upper design is advantageous in the age range from 11 to 13 years. Patterns between different parameters of schoolchildren’s feet are also determined. On the basis of the developed parametric models and the proposed principles of modular transformation the construction of low shoes (half-boots) is designed and made.
Preliminary evaluation of the effects of grapiprant compared with carprofen on acute pain and inflammation following ovariohysterectomy in dogs
Authors: Southern Brittany L. , Long Sarah M. , Barnes Danielle N. , Enomoto Hiroko , Messenger Kristen M.
Published: June 2022

OBJECTIVE

To compare the analgesic efficacy of grapiprant to carprofen for the treatment of postoperative pain and inflammation in dogs following ovariohysterectomy.

ANIMALS

12 purpose-bred adult sexually intact female Beagles.

PROCEDURES

Dogs were randomly assigned to 1 of 2 treatment groups: grapiprant (2 mg/kg, PO; n = 6) or carprofen (4.4 mg/kg, PO; n = 6), 1.5 hours prior to ovariohysterectomy (OVH) and every 24 hours afterward for 3 total doses. An ultrafiltration probe was placed within the OVH incision to collect interstitial fluid (ISF). Pain and inflammation were assessed by masked investigators via mechanical nociceptive threshold testing and the short form of the Glasgow Composite Pain Scale before drug administration and at multiple time points for 72 hours following dosing and surgery. ISF samples were collected at the same time points to assess prostaglandin E2 concentrations at the site of inflammation.

RESULTS

In both groups, pain scale scores were highest in the immediate postoperative period and decreased over time. In both treatment groups, there were significant (P = 0.003) differences in mechanical nociceptive threshold results over time when compared with baseline, but there was no difference between groups. Prostaglandin E2 concentrations in ISF were higher in dogs receiving grapiprant compared with carprofen (P < 0.001). One dog in the carprofen group required rescue analgesia.

CLINICAL RELEVANCE

Results of this preliminary study suggested both carprofen and grapiprant may be effective for postoperative pain following OVH in dogs; however, additional studies are warranted to determine grapiprant’s effectiveness in a larger and more diverse population of dogs.
Mechanical Properties of Coconut Particle Board with Variation of Material Composition
Authors: Jarlis Roni
Published: June 2022

The research carried out is a laboratory experimental research withmake particle board from coconut coir, with variations in the composition of fibers and powders used are 100 % - 0%, 90 % - 10 %, 80 % - 20 %, and 70 % - 30 % using urea formaldehyde adhesive in order to determine the mechanical properties, and find a good composition of coconut coir particle board. Sampling was carried out at the Forestry Laboratory of the Muhammadiyah University of West Sumatra. The tests were carried out at the Civil Polytechnic Laboratory of Unand, and at the Agricultural Product Technology Laboratory of Unand. The independent variables in this study were thickness and composition variation. The dependent variable is density, flexural strength or MOR. Control variables are temperature, adhesive content, particleboard thickness, compression pressure, and drying time. Data were taken by repeated measurements of 5 samples. Based on the results of the research that has been carried out, it was found that the use of coconut coir powder particles as an outer coating for particleboard at different percentages has an influence on the mechanical properties of the particle board. From the results of the study, it was found that particleboard with a composition between fiber and coconut coir powder (90% - 10%) was the best result because the less powder used resulted in good mechanical properties with a density of 0.52 g/cm3 and flexural strength or MOR 159, 43 Kg/cm2.
A aplicação de medidas atípicas no processo de execução: uma análise do Artigo 139, IV, do Código de Processo Civil
Authors: Bueno Évelyn , Cardoso Débora Tietti
Published: June 2022

Na busca pela efetividade, o Código de Processo Civil de 2015 trouxe como destaque o inciso IV do artigo 139, que instituiu um dever-poder geral executivo, autorizando o uso, a princípio, de qualquer medida voltada à materialização da decisão judicial, inclusive em demandas de caráter pecuniário. O presente artigo tem como objetivo identificar como as medidas atípicas executórias que vêm sendo aplicadas para o cumprimento de sentença nos casos de obrigação pecuniária, bem como, investigar quais os requisitos e limites para aplicabilidade de tais medidas. Demostrando, assim, a adaptação do sistema jurídico na matéria executória. A metodologia utilizada no desenvolvimento desta pesquisa foram as abordagens da pesquisa básica, exploratória e bibliográfica. Constatou-se que, para a utilização das medidas atípicas tanto o magistrado quanto os operadores de direito devem seguir certos requisitos, limites e princípios. Devendo respeitar, também, um limite temporal para que a medida atípica não se torne uma sanção punitiva, tornando assim, portanto, um processo civil justo, igualitário e eficiente no que tange a execução do crédito, sem causar desfavor a qualquer dos lados da relação jurídica.
A legitimidade funcional do Ministério Público para instaurar o inquérito civil à luz da Hermenêutica-interpretativa constitucional
Authors: Cezar Hariel Gabriel Andriollo , Bolwerk Aloísio Alencar
Published: June 2022

Trata-se de um artigo que aborda a legitimidade investigativa do Ministério Público utilizando como instrumento o procedimento administrativo pré-processual do inquérito civil.
Perspectivas econômicas pelo o Marco Civil das startups
Authors: Lana Henrique Avelino , Pimenta Eduardo Goulart
Published: June 2022

A partir das regras do Marco Legal das Startups, decorrente da LC 182/21, pretende-se neste trabalho inicialmente delimitar o que seria tecnicamente e juridicamente uma startup. A metodologia a ser utilizada é de método dedutivo, mediante abordagem explicativa e descritiva, com análise de bibliografia, nacional e estrangeira, toda ela especializada no cerne do tema. Academicamente, o problema a ser respondido é, a partir das regras do Marco Legal das Startups, identificar e distinguir os diferentes tipos de investimento para startups, bem como quais são as suas regras respectivas, trazidas pela LC 182/21. Como hipótese de resposta ao problema, abordar-se-á sobre as diversas alternativas disponíveis de investimentos. Ao final, trata-se acerca das diferentes maneiras de realizar o desinvestimento realizados pelos investidores e da nova modalidade de licitação a fim de viabilizar a contratação de startups que apresentem soluções inovadoras e tecnológicas para problemas concretos apresentados por órgãos, autarquias, empresas públicas ou de capital misto.
Autonomia e vulnerabilidade dos sujeitos nas pesquisas com seres humanos na normativa brasileira
Authors: Grischke Lucas Lopes , Timm Daniele Wachholz , Vasconcelos Rubens Vicente Rodrigues
Published: June 2022

O trabalho pretende discutir as pesquisas com seres humanos do ponto de vista bioética. As novas legislações acerca do tema tendem a retirar direitos já garantidos pelas resoluções nacionais expedidas pelo Conselho Nacional de Saúde. A divisão do texto consistirá em três tópicos. Em um primeiro momento, procuraremos abordar alguns recortes históricos do desenvolvimento da ética em pesquisa e uma síntese da legislação nacional que aborda o assunto em questão. Posteriormente, no segundo tópico discutir-se-á, em linhas gerais, o conceito de autonomia no contexto bioético, assim como as pesquisas com vulneráveis e suas particularidades. E por fim, no terceiro tópico, serão discutidas as controvérsias, relacionadas à temática, do Projeto de Lei nº 7082/2017, que dispõe sobre a pesquisa clínica com seres humanos e que institui o Sistema Nacional de Ética em Pesquisa Clínica com Seres Humanos. A metodologia foi calcada na análise bibliográfica e documental de artigos científicos na área da bioética, além de legislações e pareceres de organizações atinentes ao tema. Os resultados do trabalho concluem que é imprescindível conciliar a necessidade de incentivo ao progresso científico à proteção da dignidade humana e defesa dos direitos coletivos e individuais.
O depoimento infanto juvenil sob ótica da Lei nº 13.431/2017
Authors: Reis Junior Almir Santos , Correa Taiene Naomi S.
Published: June 2022

Crianças e adolescentes são constantemente agredidos e, portanto, vítimas de crimes bárbaros que ofendem bens jurídicos sensíveis ao direito penal. Sob esta lente, torna-se relevante conhecer as técnicas empregadas para colheita de depoimentos e declarações de crianças e adolescentes nos termos da Lei 13.431/2017. O objetivo, assim, é fazer a análise da Lei 13.431/2017, na qual foram estabelecidas medidas de assistência e proteção à criança e ao adolescente, vítima ou testemunha de crimes. Para tanto, empregou-se o método hipotético-dedutivo que consistiu na fonte bibliográfica que trata da temática.  Ao final, concluiu-se que as inovações introduzidas pela Lei 13.431/2017 garantem atendimento humanizado à criança e ao adolescente ao serem ouvidos.
A (in)existência da coisa julgada no controle concentrado de constitucionalidade
Authors: Montes Netto Carlos Eduardo , Vianna Alves Ferreira Olavo Augusto , Benedetti Marques Rodrigues Gabriel
Published: June 2022

O presente trabalho objetiva analisar a divergência doutrinária acerca da (in)existência da coisa julgada no controle concentrado de constitucionalidade. Trata-se de um tema que assume relevância diante da instabilidade das decisões proferidas pelo Supremo Tribunal Federal. Nessa perspectiva, observa-se a necessidade de analisar a incidência (ou não) dos institutos que abrangem a estabilização da jurisprudência no âmbito do Pretório Excelso. A hipótese considerada é que o enfrentamento da questão passa pela inevitável distinção entre texto e norma, pois o debate sobre a vinculação às decisões da Corte Suprema e a necessária atualização da sua jurisprudência exige cautela. O método adotado foi o hipotético-dedutivo, inferindo-se, ao final, que a melhor forma de conceber a segurança jurídica ao controle concentrado é a partir da conjugação da coisa julgada com os demais institutos que lhe são inerentes.
Establishing the essence of preventing corruption in public service
Authors: Kharchenko Vadym Borysovych , Kaganovska Tetiana Evgeniivna , Zakomorna Katerina Olexandrivna , Izbash Kateryna Serhiivna
Published: June 2022

Corruption is one of the most negative phenomena in the state system. Manifesting element of corruption has been highly experienced in public services where there is always a need in analyzing them. Without proper counteraction to corruption, it is able to nullify all previous achievements in reforming the country's mechanisms of government and stop its development. Despite some achievements of the Ukrainian state in the field of combating and preventing corruption, especially in the years after the Revolution of Dignity, society and the state leadership will have to make many efforts to significantly improve the situation in this direction. In order to select the most effective ways to prevent corruption, the positive experience of successful foreign countries in this area is studied.  Ways and methods of effective counteraction to corruption in the public service are considered.  Specific ways of combating corruption at each level of government are analyzed and compared. Peculiarities of counteracting corruption both in state authorities and in local self-government bodies are established. Emphasis is placed that without a proper improvement of the quality of public service in the state, in particular a significant improvement in combating and preventing corruption, it will be difficult or impossible to achieve a proper standard of living (well-being) in the state and society. It is established that the solution of the problematic issues outlined in this article depends on many environmental factors, first of all, such as the stability of the political regime in the state, an effective judicial system and the effective operation of law enforcement agencies.
Reassessing the concept and classification of war crimes in modern Law understending
Authors: Korotiuk Oksana Viktorivna , Bershov Hennadii Yevhenovych , Danshyn Maksum Valeryevich , Pavlichenko Volodymyr M.
Published: June 2022

War is inevitable, and its consequences devastating with lots of casualties and damages experienced. The purpose of the article is to study the concept and classification of war crimes. It has been emphasized that it is impossible to organize timely detection, effective pre-trial investigation and fair trial of war crimes cases without understanding the essence of the indicated illegal actions and the specifics of the mechanism of their commission. Analysis of the provisions of international legal acts, regulatory legal acts of Ukraine and foreign countries has been carried out. Those regulations define the concept of “war crimes”, their features and system. It has been found that there is no actual definition of war crimes in international criminal law, similar to the criminal law of Ukraine. It has been offered to understand war crimes as criminal offenses that encroach on the established procedure for performing active duty and are committed by members of the armed forces, conscripts and career reservists during reserve training, as well as their accomplices and other persons specified by law. It has been established that the criminalistics classification of war crimes allows us to form the appropriate forensic methods, to choose the right direction, means, tactics and investigation plan. The authors have accomplished criminalistics classification of war crimes according to a mixed criterion, which is stipulated by such criminal and forensic significant features of the indicated criminal offenses, as the characteristics of the offender’s personality, direction, situation and methods of commission.
The relative productivity exponent in global economy
Authors: Seidametova Zarema Seidalievna , Temnenko Valery Anatolievich
Published: June 2022

The purpose of the study is to introduce a new economic index, the "relative productivity exponent in the global economy g", which characterizes the deviation of the economic productivity index (EPI) of a given country from some ideal productivity determined by the shape of the axial line of the swarm of the global economy in the three-dimensional space of economic indices EPI, BLI, CPI. To determine the values of the relative productivity exponent g, the shape of the axial line of the global economy of 2019, established earlier by the authors, is used. The article examines the distribution of countries according to the exponent g and the index of socio-economic equilibrium of countries , and also investigates the relationship between the exponent g and the index of economic productivity EPI. The scientific novelty of the research lies in the introduction of a new economic index g and the calculation of its values for countries based on economic data from 2019. The distribution of countries according to the value of g allows us to reveal, as a result, a certain range of the exponent g, indicating a balanced state of the economy.
Optimization of trading account fraction in exchange transactions
Authors: Maliarov Anatoli Nikolaevich
Published: June 2022

The purpose of the research is to study and analyze newspaper texts on the problem under study; identification of the main points of the ecological crisis and its impact on many aspects of human life. This study is a survey of publicistic articles on economic topics to identify the current economic situation in Europe. At present, the problem of the economic crisis occupies a dominant role all over the world, since this is the time for the formation of new models of the economy in conditions of environmental, pandemic, and, consequently, economic crises. Analysis and review of media materials and materials of scientific and practical conferences and symposia dedicated to sustainable development in the context of ensuring the economic and environmental security of territories, as well as the projected developments of state authorities and authorities on this topic and an assessment of the economic consequences that European countries are experiencing due to environmental disasters in the proposed article made it possible to identify the scale of damage to the world economy. As a result, the most informative parameters were obtained, showing the current state of the economic crisis in Europe.
Identification of investment directions in the regions of the North-West based on the data of the digital platform "Investment Projects"
Authors: Pesotskiy Andrey Alekseevich
Published: June 2022

The purpose of the research is to identify the structure of investment projects in the regions included in the Northwestern Federal District on the basis of the data of the digital platform "Investment Projects". The scientific novelty consists in determining the sectoral structure of investments in the Northwestern Federal District, based on the forms of systematization of information used on this portal. The result of the study is the identification of industry specifics of each region and the selection of three groups of regions based on the level of investment attractiveness.
Standardization of Optimized Anti-diabetic Polyherbal Formulation by HPLC
Authors: Kumar Arun , Kalia Ajudhia Nath , Singh Harsimran
Published: June 2022

Herbal drugs are widely used to treat and prevent various diseases with more than 80% of people worldwide relying on them for their primary healthcare. Polyherbal formulations express high effectiveness in various diseases due to their synergistic effect. Herbal formulations are required to standardize in order to assess their quality, purity, and biological efficacy. The present study aimed to prepare a polyherbal formulation comprising of lyophilized ethanolic extracts of three well known anti-diabetic herbal drugs (Momordica charantia, Andrographis paniculata and Withania somnifera), and three formulations were developed in combination ratios (1:1:1, 2:1:2, and 2:2:1) respectively and to develop high-performance liquid chromatography (HPLC) method for assessment of purity, standardization and estimation of markers. In addition, developed formulations were optimized on the basis of oral glucose tolerance test (OGTT). Standardization of developed polyherbal formulations was performed by using respective biological markers (Vicine, andrographolide, withaferin-A and withanolide-A) by HPLC technique. HPLC was performed using RP-18, Merck column to study the presence and quantification of respective markers at a wavelength of 237 nm. The HPLC study revealed the presence of vicine, andrographolide, withaferin-A, and withanolide-A in quantifiable amounts in respective extracts. OGTT study was performed using normal albino Wistar rats at a drug dose of 500 mg/kg body weight. Rats were divided into six groups, including three combination ratios and standard (Metformin) group. An optimized ratio 2:2:1 showed a significant decrease in blood glucose levels compared with standard control rats.
Development and In Vivo Evaluation of Pitavastatin Self-Emulsifying Drug Delivery Systems
Authors: Ganesh Bommareddy Srinivasa Padma , Bhikshapathi Darna
Published: June 2022

The current research was intended at formulation and in vivo evaluation of pitavastatin self-nanoemulsifying drug delivery system (PTN SNEDDS) for enhanced drug dissolution and bioavailability. Solubility studies carried out to construct pseudo ternary phase diagram employing the blends of oil (capmul PG8), surfactant (acrysol K140), and cosurfactant (transcutol P).The PNT SNEDDS prepared and optimized by adopting response surface methodology employing 33 Box-Behnken design. The SNEDDS formulations characterized for % drug content, % entrapment efficiency, in-vitro release studies, particle size, zeta potential, FTIR and SEM studies. The bioavailability studies carried out in wistar rats. The study indicated that PTN12 comprising of 40% capmul PG8, 40% acrysol K140 and 30% transcutol P displayed  minimum droplet size (24.8 nm), optimal  zeta potential (-10.4 mV) and maximum drug release (98.75%). The SEM data revealed that droplet size is in nanometer range. The pharmacokinetic studies conducted in rats indicated that Cmax of optimized PTN SNEDDS (2.25±0.02ng/ml) was higher than pure PTN suspension (0.75±0.03ng/ml) and optimized SNEDDS exhibited superior oral bioavailability about 4 times of AUC, along with higher plasma concentration than pure drug. The above results indicated that application of SNEDDS formulation technique for PTN increases solubility and dissolution.
NOVEL BENZIMIDAZOLE ACETAMIDE DERIVATIVES AS ANTIBACTERIAL AND ANTI-TUBERCULAR AGENTS: SYNTHESIS AND CHARACTERIZATION
Authors: Hakim Farhana , Salfi Roshan
Published: June 2022

The current study focused on the development of novel potentially active anti-microbial agents based on the benzimidazole-acetamide system. A novel series of various substituted benzimidazole- N- phenyl acetamides was synthesized through a feasible scheme characterized by IR, Proton nuclear magnetic resonance (1HNMR), and MASS spectral methods. All the synthesized compounds were screened for anti-bacterial activity against two gram-positive strains: Staphylococcus aureus, Bacillus subtilis; four gram-negative strains: Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, and Klebsiella pneumonia; and anti-tubercular activity against mycobacterial strain: Mycobacterium tuberculosis. Among the 15 compounds (6a–6o) tested, three compounds, 6e, 6f, 6l, and 6m demonstrated high potency with MIC values ranging from 6.25–12.5μg/mL against both gram-positive and gram-negative strains. In addition, compounds 6e, 6f, and 6l displayed the highest anti-tubercular activity with a MIC value of 25μg/mL.
Formulation and In Vivo Evaluation of Trilayer Matrix Tablets of Rosuvastatin Solid Dispersions by Geomatrix Technology
Authors: Chinthala Shanthi Priya , Thummaluru Ramamohan Reddy
Published: June 2022

The current research is aimed at enhancing the aqueous solubility and sustains the drug release of rosuvastatin BCS Class II drug. 15 solid dispersion (SD) formulations of rosuvastatin prepared by solvent evaporation technique and evaluated. In vitro drug dissolution study indicated higher drug dissolution rate for SD13 of 99.74±5.39 % within 60 min. Eight formulations of rosuvastatin trilayer matrix tablets (AF10-HF10) were prepared by incorporating optimized SD13 by direct compression method. These trilayer formulations characterized for flow properties and physicochemical parameters. The maximum drug release was exhibited by trilayer matrix formulation (HF10) of 99.48±5.40 % over a period of 24 h. The release profile of the optimized formulation (HF10) was described by the zero order and best fitted to Higuchi and Korsmeyer-Peppa’s model. The results demonstrated the sustainability of rosuvastatin trilayer tablets with enhanced release time and linearity upto 24 h. From in vivo bioavailability studies Cmax of the rosuvastatin optimized ER tablets and marketed product was found to be 28.46±0.07 ng/mL and 30.94±0.75 ng/mL respectively. Tmax of both rosuvastatin optimized ER tablets formulation and rosuvastatin marketed product was 5±0.06 and 4±0.03 h, respectively. AUC0-∞ infinity for optimised formulation was higher (395.54±1.37 ng.h/ml) than the rosuvastatin marketed product formulation 212.54±0.42 ng.h/ml. Statistically, AUC0-t of the optimized ER tablets formulation was significantly higher (p<0.05) as compared to rosuvastatin marketed product formulation. In vivo pharmacokinetic studies in rabbits confirmed the prolonged release by showing increase in bioavailability for Rosuvastatin from optimized ER tablets than marketed formulation.
Ex-vivo and in-vivo evaluation of nanostructured lipid carrier loaded with gemcitabine and paclitaxel in A549 lung cell for management of resistant cancers
Authors: Yadav Amrendra P. , Kori Mohan Lal
Published: June 2022

The combination of gemcitabine (GEM) and paclitaxel (PTX) are effective anti-cancer regimens due to their different mechanisms of action and partially non-overlapping toxicities. The present study aimed to elucidate a potential effect of folic acid-conjugated-Gemcitabine-Paclitaxel-loaded nanostructured lipid carriers (FA-GEM-PTX-NLCs) on the proliferation of cancer cell lines A549 for the management of resistant cancer. Cell uptake of NLCs in A549 cell lines was carried out with fluorescent dye, and Fluorescein isothiocyanate loaded NLCs (FITC-NLCs). Flow cytometry showed that FA-PTX-GEM-NLCs exhibited enhanced cellular uptake via folate receptor-mediated endocytosis. Cytotoxic effect (GI50) of formulations was measured by MTT assay method using A549 cells. Cytotoxicity results reveal that the GI50 of FA-GEM-PTX-NLCs was 2.16 μg/mL, which is three times less than the GI50 (6.48 μg/mL) GEM-PTX-NLCs. Furthermore, data obtained from the pharmacokinetics study explored the extended half-life and higher serum concentration of GEM and PTX when delivered through FA-PTX-GEM-NLCs compared to PTX-GEM-NLCs and free drugs. Tumor growth inhibition results advocate for the higher anti-tumor activity of FA-GEM-PTX-NLCs in A549 cell line induced tumor-bearing Balb/c mice by estimating tumor burden. In conclusion, the novel folic acid conjugated NLCs loaded with GEM and PTX could be used as a potential chemotherapeutic formulation for cancer management.
EVALUATION OF IMMUNOMODULATORY EFFECT OF T-AYU-HM PREMIUM IN EXPERIMENTAL ANIMAL MODELS
Authors: Desai Atul , Desai Hemshree A. , Desai Rutvij A. , Merai Ankit K. , Desai Chirag , Khan Maryam , Paul Arindam
Published: June 2022

To evaluate the immunomodulatory effect of T-AYU-HM Premium in experimental animal models. Female Wistar rats were divided into four groups in each model and acclimatized under standard conditions. The control group received vehicle (0.5% CMC), the standard group received Levamisole (50 mg/kg), Test-1 group received T-AYU-HM Premium (600 mg/kg), and Test-2 group received T-AYU-HM Premium (1200 mg/kg). The effect of T-AYU-HM Premium as an immunomodulator was studied by evaluating the neutrophil adhesion model, carbon clearance model, cyclophosphamide-induced neutropenia model, and haemagglutinating antibody titer model. The neutrophil adhesion in standard, Test-1, and Test-2 are 55.39%, 23.32%, and 38.06%, respectively. The %reduction of TLC and DLC in standard and both test groups were significant compared to the control group after nylon fiber treatment. The phagocytic index of standard, test-1 and test-2 was found to be 0.01735, 0.01416, and 0.00923, respectively, this indicates that the test drug affects the reticuloendothelial system. A significant decrease in cyclophosphamide-induced neutropenia implies that the cyclophosphamides’ influence on the hemopoietic system is lessened. The percentage reduction in TLC of standard and both test drug groups are 11.12%, 20.66%, and 13.43%, respectively. The %reduction in DLC of standard and both test drug groups were significant compared to a control group. Haemagglutinating antibody (HA) titer test determines the effect of the drug on humoral immunity. Primary HA titer values of standard, test-1 and test-2 were 5.33, 2.66, and 4.50, respectively. Secondary HA titer values of standard, test-1, and test-2 were 13, 7.16, and 11.16, respectively. HA titer value significantly increases in standard and test groups compared to control in both primary and secondary evaluation. In the current study, results show that the T-AYU-HM Premium tablets exhibit Immunomodulatory activity.
Sub-chronic Toxicity Study Of T-AYU-HMTM Premium: A Herbo-mineral Formulation
Authors: Desai Atul , Desai Hemshree , Desai Rutvij , Merai Ankitkumar H , Kalan Maitri , Desai Chirag , Paul Arindam
Published: June 2022

To perform a sub-chronic toxicity study and to generate scientific data regarding the safety profile of T-AYU-HMTM Premium, a herbo-mineral formulation used for sickle cell disease. Experimental animals (Mice) were divided into six groups and were acclimatized and treated with 125 mg T-AYU-HMTM Premium/kg body weight (T1 LD), 625 mg T-AYU-HMTM Premium/kg body weight (T2 MD), and 1250 mg T-AYU-HMTM Premium/kg body weight (T3 HD) and two group of satellite daily for 90 days. 0.5% CMC was administered to the control group as a vehicle. The satellite groups were treated with 125 mg T-AYU-HMTM Premium/kg body weight (S1 LD) & 1250 mg T-AYU-HMTM Premium/kg body weight (S2 HD, 1250 mg/kg) receiving low & high dose respectively. The mice were closely observed for a clinical sign of toxicity, stereotypical behavior and alteration in autonomic activity during the entire study period. Hematological and blood biochemical parameters were observed on days 0, 60, 90. Motor coordination activity and sensory stimuli assessment were performed after the 11th week. At the termination of the study, all animals were sacrificed, and organs such as the heart, brain, kidney, liver, etc., were collected & observed for histopathology. There was no change in the normal gross behavior of animals in the sensory and motor assessment activity in the treatment group compared to the control group. Evaluation of hematological parameters shows a significant increase in red blood corpuscles. Histopathological examination of various organs shows a normal architecture in all the treated groups. T-AYU-HMTM Premium was found to be safe on repeat dose oral administration in NOAEL, dose up to 1250 mg/kg body weight when administered orally for 90 days in both the sexes of Swiss Albino mice.
Case Report Study of an Integrated Treatment Approach in Critical Case of Covid-19 Patient
Authors: Desai Atul , Desai Kavita , Desai Hemshree , Desai Rutvij , Desai Chirag
Published: June 2022

The world has seen various variants of coronavirus and attempting all the feasible options to combat this pandemic situation. By far, vaccination is the most remarkable approach in controlling the Pandemic. India is fighting against the delta variant of the second wave COVID-19. Meanwhile, World Health Organization has already warned about the initial stages of the third wave in all countries. Therefore, on considering the variants of coronavirus, no standard option of care is available to date. In this article, we present a case study on the clinical outcome of the integrated treatment approach in COVID-19 patients suffering from critical conditions. The patient with a history of coronavirus was advised of strict home quarantine and standard treatment of care for 14 days. She was brought to the COVID-19 healthcare center in an unconscious state by her family. On examination, she had a 79% oxygen saturation, heart rate 88 beats/minute and her laboratory findings: CRP 37.3(mg/dL), ESR 84(mm/hour), D-dimer 793(ng/mL), and RBS 158 mg/d. After receiving consent from her family members, we initiated the integrated treatment approach. It includes T-AYU-HM Premium 600mg, is a herbo-mineral formulation, and Acupen 600 mg thrice a day with modern medicines. By adhering to the treatment, she recovered completely within a one-month duration. Her HRCT report showed a significant reduction in lung involvement with ill-defined low-density ground-glass opacities and atelectatic bands in both lungs. The patient's vitals and laboratory parameters presented striking improvement. This case study provides information about the effect of the integrated treatment approach in critical COVID-19 cases.