bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma melatonin concentration during the early post-partum period in Thoroughbred mares and their foals
Authors: Gáspárdy András , Gallagher Gemma , Bartha Boróka , Cseh Sándor , Fekete Sándor György , Somoskői Bence
Published: September 2023

The authors aimed to determine the plasma melatonin concentration in mares and their new-born foals in the early post-partum period. Blood samples were collected from the jugular vein of 53 mare-foal pairs within twelve hours after parturition. Plasma melatonin levels were measured by ELISA. The melatonin concentration, adjusted for the moment of parturition using a generalised linear model, was 34.58 pg mL−1 in mares. It was significantly lower (27.63 pg mL−1) in the new-born foals. However, the melatonin concentration declined differently by the end of the twelve hours, it decreased less in the offspring than in the mothers. An artificial light supplementation at the end of gestation reduced the melatonin concentration both in mares and their foals by about 10 pg mL−1, compared to the controls. An elevated melatonin production may be related to preparation of mares for parturition and ensures the chances of survival of offspring, therefore the melatonin may reach its peak at the moment of foaling regardless of its actual time. The effect of low melatonin concentration in new-born foals might be associated with the foal's health and subsequent performance. The need to monitor the melatonin concentration in the offspring justifies further studies.
Heretics as devil’s servants. The construction of religious otherness in Silesian historiographical sources from the late Middle Ages
Authors: Radek David
Published: September 2023

Since the times of St Augustine, the medieval society was firmly convinced about the connection between heresy and the devil, and heretics were often considered members of the civitatis diaboli. In the Silesian milieu, a similarly constructed religious identity can be more often encountered in the late Middle Ages, when the society was facing the threat of Hussitism. This was reflected in the works of contemporary chroniclers (e.g., Peter Eschenloer, Caspar Borgeni, Johannes Froben, etc.). The descriptions of heretics were created in accordance with the already existing Christian tradition and predominantly consisted of stereotypes and topoi associated with heresy. The paper focuses on the analysis of narrative strategies used by Silesian chroniclers and endeavours to explain how the image of heretics was created, with an emphasis on the role the devil played in these descriptions, therefore it analyses the relationship between heretics and the devil.
Grain Storage Forum ELEVATOR 2023
Authors: «ПроАгро Груп» компанія
Published: September 2023

2 червня 2023 року у Києві пройшов найбільший в Україні форум в галузі зберігання, переробки, логістики і трейдингу зерна – V Міжнародний Grain Storage Forum ELEVATOR 2023, організований компанією «ПроАгро Груп», Асоціацією елеваторів України та Спілкою «Борошномели України», який став черговою масштабною подією року на вітчизняному аграрному ринку для фахівців зерновиробництва і суміжних галузей.
Pensares y haceres para una comunicación decolonial
Authors:   Universidad Autónoma de Puebla, Castro Lara Eloína , Torrico Villanueva Erick Rolando ,   Universidad Andina Simón Bolívar, Cebrelli Alejandra ,   Universidad Nacional de Salta
Published: September 2023

Este trabajo busca introducir las discusiones en torno a la Comunicación y a la Decolonialidad desarrolladas en el Grupo Comunicación-Decolonialidad durante las últimas tres ediciones de los congresos bienales de la Asociación Latinoamericana de Investigadores de la Comunicación (ALAIC) y que representan un reto epistemológico-ético-ontológico para problematizar la relación dinámica entre ambos componentes (Comunicación-Decolonialidad), se ha priorizado la síntesis dialógica entre la vivencia y los textos desarrollados por investigadores participantes en el GI Comunicación-Decolonialidad desde 2016, que han dado origen a una otra comunidad argumentativa dentro del campo comunicacional latinoamericano y a un espacio colectivo sentipensante entre autores de este libro, con la firme apuesta en una otra Comunicación posible.
Elaboración de un plan de gestión de proyectos
Authors:   Universidad Cooperativa de Colombia, Campo Sierra Shester Jesús
Published: September 2023

La preocupación por tener claros los pasos para administrar, controlar y administrar los recursos físicos y financieros de algunas actividades emprendidas ha sido motivo para originar el Project Management. Hoy en día existen una cantidad de cursos, certificaciones, formación especializada o específica sobre los proyectos y así entender cada uno de los procedimientos para llevar a cabo una buena gestión. Actualmente, muchos emprendedores, el personal del sector público y de organismos sociales quiere saber: ¿qué es un proyecto?, ¿cuáles son los pasos mínimos a tener en cuenta?, y ¿cómo gestionarlo? Pues bien, mediante la presente guía de práctica se desea mostrar generalmente qué se debe realizar para elaborar un plan para la gestión de proyectos. La guía se basa en libros teóricos y prácticos, la experiencia adquirida a lo largo de mi vida profesional y empresarial, y, por último, lo diferentes aportes generados a través del tiempo del PMBOK y la Metodología de Marco Lógico, implementada por el Banco de Programas y Proyectos BPIM administrado por DNP, los cuales brindan un importante aporte.
Manual de prácticas pedagógicas de la Facultad de Educación de la Universidad Cooperativa de Colombia, sede Bucaramanga
Authors:   Universidad Cooperativa de Colombia, Tarazona Ariza Silvia Andrea
Published: September 2023

Este manual se piensa como un documento fundamental para la regulación de las prácticas pedagógicas que se llevan a cabo en la Facultad de Educación de la Universidad Cooperativa de Colombia campus Bucaramanga. Contiene información relevante y detallada sobre los aspectos teóricos y los procedimientos aplicables a la realización del ciclo de prácticas pedagógicas de las licenciaturas de manera óptima y responsable. Cada apartado desarrollado en este manual cuenta con la descripción de las actividades pedagógicas que han de realizar nuestros maestros en formación, supervisados por los profesores orientadores en los diferentes centros de prácticas, apuntando a clarificar todas las posibles dudas existentes sobre el desarrollo de las prácticas pedagógicas en las instituciones con las que tiene convenio la Facultad de Educación. Igualmente, se da cuenta de los objetivos generales y específicos que se deberán lograr por medio del desarrollo de las prácticas pedagógicas, la conceptualización teórica que fundamenta la razón de ser de este ciclo formativo mandatorio dentro de los programas de licenciatura, así como los derechos y deberes que los maestros en formación y los docentes orientadores deben conocer para el buen desarrollo de las prácticas pedagógicas en los diferentes colegios donde se llevan a cabo las intervenciones propias de las prácticas pedagógicas.
ENDÜSTRİ 4.0 DEVRİMİNİN EKONOMİK BÜYÜMEYE ETKİLERİ ÜZERİNE PANEL VERİ ANALİZİ
Authors: AYDINBAŞ Gökçen , ERDİNÇ Zeynep
Published: September 2023

Endüstri 4.0 dijitalleşme süreci ekonomik faaliyetlerin temelini bilgi toplama ve işleme üzerine kurmuştur. Bu durum ticari faaliyetleri de artırarak kolaylaştırmaktadır. Bu bağlamda, Endüstri 4.0’ın ekonomiler üzerindeki etkilerinin araştırılması, günümüz dijital çağında oldukça önemlidir. Endüstri 4.0 devriminin ekonomik büyümeye etkileri, ilgili dönüşümün ekonomik, sosyal ve sektörel sonuçlarının anlaşılması bağlamında araştırılması gereken bir konudur. Bu araştırmalar ile politika yapıcılarına ve işletmelere stratejik karar alımlarında yol gösterici ve rekabet avantajı sağlayıcı potansiyeller sunulabilmektedir. Bu çalışmanın amacı Endüstri 4.0’ın ekonomik büyümeye etkilerini, bu dönüşüme ilişkin stratejileri ve hedefleri olan 18 ülke üzerinden panel veri analiz yöntemi ile araştırmaktır. Bu kapsamda kurulan modelin tahmininde 2000-2019 dönemine ait yıllık veri setinden yararlanılmıştır. Çalışmada, bağımlı değişken iktisadi büyümeyi temsil eden kişi başına gayrisafi yurt içi hâsıla (GSYH) iken, bağımsız değişkenler Endüstri 4.0’ı temsil eden değişkenler olan patent başvuru sayısı, orta ve ileri teknoloji ihracatı, bilgi iletişim teknoloji ihracatı olarak belirlenmiştir. Çalışmada ulaşılan sonuç, uzun dönemde patent başvuruları ile orta ve ileri teknolojinin ihracattaki payında gerçekleşen artışın kişi başına geliri artırdığı şeklindedir.
Comprehensive analysis of a NAD+ metabolism-derived gene signature to predict the prognosis and immune landscape in endometrial cancer
Authors: Hu Dan , Du JunHong , Cheng YueMei , Xing YiJuan , He RuiFen , Liang XiaoLei , Li HongLi , Yang YongXiu
Published: September 2023

As a crucial regulator influencing tumor progression, nicotinamide adenine dinucleotide (NAD+) is widely acknowledged. However, its role in endometrial cancer (EC) is not completely understood. In this study, we aimed to develop an NAD+metabolic-related genes (NMRGs) risk signature that could reflect the prognosis of EC patients and their responsiveness to immunotherapy and chemotherapy. Data from The Cancer Genome Atlas (TCGA) databases and the Molecular Signatures Database (MSigDB) confirmed two distinct NMRG subtypes in EC patients using consensus clustering, and a risk score was constructed utilizing an NAD+-related prognostic signature depending on the least absolute shrinkage and selection operator (LASSO) Cox regression analysis. Receiver operating characteristic (ROC) curves were employed to assess the model’s precision. Additionally, we used Gene Set Enrichment Analysis (GSEA) to predict the biological signaling pathways that might be involved. We also explored the role of the risk score in immune cell infiltration, tumor mutation burden (TMB), immunotherapy, and chemotherapy. Our study established a prognostic risk signature based on six NMRGs, and we observed that the high-risk group was associated with a poorer prognosis. Furthermore, we identified a strong correlation between the high-risk group and several pathways, including DNA replication, cell cycle, and mismatch repair. Lastly, our findings highlighted the influence of NMRGs on the regulation of immune infiltration in EC. Therefore, this signature holds potential value in predicting the prognosis of EC patients and guiding their management, including decisions regarding immunotherapy and chemotherapy, ultimately improving the accuracy of EC patient care.
A BIBLIOMETRIC ANALYSIS ON UNIVERSITY CAMPUSES
Authors: KUYRUKÇU Zafer , BERBER Ayşegül
Published: September 2023

Aim: The study, it is aimed to examine the content of postgraduate thesis studies on university campuses. Method: The bibliometric analysis method was used to reveal a general profile of the studies. 132 theses were reached through the CoHE Thesis Center database. The theses were analyzed within the scope of a year, type, subject, gender of the author, the title of the advisor, the language of publication, number of pages, the university published, type of university, institute, and department. Results: The theses published are mostly written by female authors, are generally carried out by advisors with the title of professors, and have a high percentage of the Turkish publication language. Master’s theses are the majority, and most theses have been prepared at the Middle East Technical University. The studies have focused on similar issues and the concepts of ‘accessibility’ and ‘sustainability’ have been studied on campuses in recent years. Conclusion: Although the first universities in the form of campuses started to form in the second half of the 20th century in our country, the first thesis was prepared in 1989. This situation shows that it is late in terms of timing. Today, with the increasing number of universities, the theses for university campuses will increase gradually
Novel Studies in the Designs of Natural, Synthetic, and Compound Hydrogels with Biomedical Applications
Authors:   Universidad Autónoma de Coahuila, Cuéllar Gaona Claudia Gabriela , Ibarra Alonso María Cristina ,   Universidad Autónoma de Coahuila, Narro Céspedes Rosa Idalia ,   Universidad Autónoma de Coahuila, Téllez Rosas María Maura ,   Universidad Autónoma de Coahuila, Reyna Martínez Ricardo ,   Universidad Autónoma de Coahuila, Luévanos Escareño Miriam Paulina ,   Universidad Autónoma de Coahuila
Published: September 2023

Hydrogels are gaining widespread popularity in the biomedical field due to their extraordinary properties, such as biocompatibility, biodegradability, zero toxicity, easy processing, and similarity to physiological tissue. They have applications in controlled drug release, wound dressing, tissue engineering, and regenerative medicine. Among these applications, hydrogels as a controlled drug delivery system stands out, which releases active substances in precise amounts and at specific times. To explore the latest advances in the design of hydrogels, a literature review of articles published in indexed scientific journals, in Scopus and Science Direct, was carried out. This review aimed to discover and describe the most innovative hydrogel research with applications in the biomedical field; hydrogels synthesized with polymers of different origins were selected, such as; i. Natural (dextran, agarose, chitosan, etc.); ii. Synthetic (polyacrylamide, polyethylene glycol, polyvinyl alcohol, etc.); iii. Composites (interpenetrants, hybrid crosslinkers, nanocomposites, etc.). Comparative analysis revealed that hydrogels with composite materials show the most promise. These composite hydrogels combine the advantages of different polymers or incorporate additional components, offering enhanced properties and functionalities. In summary, hydrogels are versatile biomaterials with immense potential in biomedicine. Their unique properties make them suitable for diverse applications. However, innovative designs and formulations must continue to be explored to further advance the capabilities of hydrogels and expand their biomedical applications.
Rodent Facility Environmental Summary v1
Authors: Dukes Debra
Published: September 2023

Mice (Mus Musculus) are the most common research organisms used in biomedical research. We have housed and maintained a variety of strains at the Stowers Institute for Medical Research since 2000.Our environment and housing parameters provide a standardized guideline for our staff to follow.This information assures the protection of our research using the rodent model, with proper use of housing, nutrition, maintenance, and environmental enrichments for the healthiest rodent specimensfor our research. The provided guideline is currently being used at the Stowers Institute in 2023.
High-Throughput Generation of Single Cell Libraries using SmartSeq2 Plate Assay v1
Authors: Borja Michael , Muris Consortium Tabula , Hosseinzadeh Shayan
Published: September 2023

As part of the larger efforts of Quantitative Cell Science at the Chan Zuckerberg Biohub, single cell plate-based protocols such as the SmartSeq 2 assay has been frequently utilized to generate compendium of cell atlas data. With the help of previous works of MACA (mouse aging cell atlas), the Genomics platform has optimized Smartseq2 assay with the assistance of high-throughput liquid dispensers from SPT LabTech and ViaFlo. Here, we list the latest protocol detailing the generation of single cell libraries for most projects that utilize plate-based RNA sequencing.
Gibson Assembly Cloning v1
Authors: Y Chiang Claire
Published: September 2023

Gibson assembly requires a vector backbone and one or more inserts that have been PCR amplified. The inserts should have 15-20 base pairs of overlap at ligation sites, so primers used to amplify the inserts should contain a tail overhang with this homology. The vector backbone should be linear. A Gibson reaction uses a master mix that can be homemade or commercially purchased. Add the appropriate amount of master mix, then your vector and insert at 2-3 fold molar excess for a 20 µl reaction. Exact ratios will need to be optimized based on the size of your vector and inserts and how many inserts you have. Incubate this reaction at 50°C for 60 minutes. Then transform this reaction into DH5 alpha (or competent cell of choice) and plate on LB agar with appropriate antibiotic.
A method for the temperature-controlled extraction of DNA from ancient bones v2
Authors: Essel Elena
Published: September 2023

We here provide a protocol for the decontamination of ancient bones and teeth that is based on a temperature-controlled, sequential release of DNA. DNA can be extracted from all fractions generated with this method and the fraction with the highest proportion of endogenous DNA identified for further analysis. The protocol proceeds through repeated incubation of the sample powder in phosphate buffer at 37, 60 and 90 °C, followed by the complete lysis of the residual sample powder. As DNA is denatured at high temperature, subsequent DNA extraction and library preparation has to be performed using methods optimized for single-stranded DNA.
Google Earth Engine aplicado ao mapeamento pluviométrico no Triângulo Sul Mineiro – Brasil
Authors: Fuzzo Daniela  Fernanda da Silva , Ferreira da Silva Letícia , Fischer Filho João Alberto
Published: September 2023

Estimativas de precipitação por satélite têm sido propostas em vários trabalhos científicos, contribuindo como uma ferramenta importante para a consistência dos dados, além de diferentes aplicações de inovação refere-se à automação das tarefas, isso proporciona precisão e maior qualidade à própria base de dados. Os objetivos foram avaliar a espacialização da precipitação e a plataforma Google Earth Engine (GEE) no contexto de análise de dados. Foram analisadas a distribuição espacial da precipitação pelo satélite TRMM. Foi possível constatar a variação das chuvas, e verificou-se que a condição de ano seco habitual e chuvoso não se refere essencialmente à altura pluviométrica anual, mas à distribuição das chuvas no decorrer dos meses e a delimitação dos períodos (sazonalidade). Essas estimativas, quando comparadas com valores pontuais, mostram que podem fornecer boa noção da distribuição espacial das chuvas.
Efficacy of ultrasound-guided TAP block for postoperative pain relief in abdominal surgeries: A prospective, randomized controlled trial
Authors: Sanghavi Heena , Shelgaonkar Vaishali
Published: September 2023

: Transversus abdominis plane (TAP) block has emerged as a safe, reliable, and efficient technique to provide post-operative analgesia for a range of abdominal procedures and has been shown to minimize the usage of opioids in the perioperative period. This paper compares the overall efficacy and safety of TAP block for postoperative analgesia in abdominal surgeries, by two techniques (blind v/s USG).

Eighty patients, ASA grade I-II, 18-60 years age group, posted for abdominal surgery like appendicectomy, appendicular perforation, umbilical, paraumbilical, incisional and ventral hernia repair, hysterectomy and exploratory laparotomy under GA. They were divided into two groups to undergo blind or USG-guided TAP block. At the end of the procedure, before the reversal, both groups received a TAP block with Inj. Bupivacaine 0.25% 20cc on each side in supine position. Patients were followed up for 24 hours, and pain scores were measured using a visual analogue scale. Inj. Diclofenac was given as rescue analgesic and Inj. Tramadol was used for breakthrough pain. Total analgesic requirement for 24 hours and complications if any, were noted.

: VAS score was found to be significantly lower in USG- guided group at various time intervals till 12 hours (2.05 ± 0.75 vs 2.98 ± 1.03) in the USG-guided group as compared to the blind group (p<0.05). Time to first rescue analgesic was significantly prolonged in USG- the guided group being 19.68 ± 4.90 hours than the blind technique of 13.48 ± 6.86 hours (p <0.001). The number of rescue analgesics required in the USG-guided group was significantly lower than the blind technique (p<0.05).

: USG-guided group had significantly less pain scores postoperatively and a reduced number of analgesic requirements. This resulted in fewer opioid-mediated side effects. TAP block can serve as a part of multimodal analgesia with enhanced recovery after abdominal surgery. The USG-guided approach helped in achieving near perfect block which is evident by pain scores and reduced analgesics required.
Study of the effect of timing of pre-operative administration of dexamethasone and ondansetron on post-operative nausea and vomiting follow laparoscopic cholecystectomy: A prospective randomized control trial
Authors: Mahajan Shweta , Garg Manjula , Singh Surinder
Published: September 2023

: Post-operative nausea and vomiting (PONV) is potential complication in patients after laparoscopic cholecystectomy. The incidence rate of PONV after laparoscopic cholecystectomy (LC) is 46-75% which is higher than that after other types of surgery. The present study was aimed to compare the effect of timing of dexamethasone and ondansetron alone when given 45 minutes before induction or given just before induction of anaesthesia for control of PONV in laparoscopic cholecystectomy.

: Tocompare the effect of timing of dexamethasone and ondansetron each when given 45 minutes before induction or given just before induction for control of PONV in laparoscopic cholecystectomy.

: After approval by the institutional ethics committee, this study was carried out on 200 patients of both sexes in the age group of 20-60 years. It was a randomized controlled trial. And after obtaining the consent, the patients were allocated in four groups randomly. Group A: 8 mg dexamethasone 45 minutes before induction, Group B: 4 mg ondansetron 45 minutes before induction, Group C: 8 mg dexamethasone just before induction and Group D:4 mg ondansetron just before induction. Patients were observed for 24 hours after surgery for any episode of nausea and vomiting for 24 hours. Patient satisfaction with the management of PONV symptoms using 10 points verbal rating scale was accessed (VRS, 0=not satisfied, 10 = fully satisfied).

: Incidence of nausea and vomiting was significantly higher in group B was 68% and D 50% in comparison to group A 28%and C 36% (P=0.003). PONV score was highly significant when ondansetron was administered 45 minutes before induction as compare to dexamethasone when administered 45minutes before induction. The effect of ondansetron was also significant in PONV score of 24 hrs in comparison to dexamethasone.

: The ondansetron appears to have a shorter duration of action in comparison to dexamethasone. Timing of administration of ondansetron is important in laparoscopic cholecystectomy before surgery as it has bearing on the incidence of vomiting and rescue antiemetic required. It was found that administration of ondansetron just before induction still delays the onset of PONV in comparison to when given 45 minutes before induction.
A randomised, prospective, double blind study of intraperitoneal instillation of 0.25% bupivacaine with clonidine versus 0.25% bupivacaine with dexmedetomidine for post-operative analgesia in patients undergoing laparoscopic cholecystectomy
Authors: Shruthi R  , Jutoor Achyutha Setty
Published: September 2023

Laparoscopic cholecystectomy is the standard and most accepted technique for Cholecystectomies due to lesser postop pain and short recovery time.The origin of abdominal and shoulder pain after laparoscopic procedures has led to the use of intra peritoneal instillation of local anaesthetic agent to reduce postoperative pain.

To assess the efficacy and quality of postoperative analgesia between the study groups using Visual Analogue Scale (VAS) score at various time intervals along with side effects if any.

: 60 patients belonging to ASA 1 and 11 categories posted for Laparoscopic Cholecystectomy were given General Anaesthesia. After completion of surgery, before removing the trocar, anaesthetic study solution was sprayed on the surface of liver, gall bladder bed, right sub-diaphragmatic space, and port sites in Trendelenburg position. Volume and dilution of two drugs were same in both groups. Bupivacaine (0.25%) 50 mL; Dexmedetomidine (1 µg/kg) (BD) or Clonidine (1 µg/kg) (BC) was used. VAS score, Heart rate and BP measured at various time intervals and the time of first rescue analgesia noted.

: VAS of BD group was 5.27 ± 0.64 to 3.70 ± 0.837 from 1 hour to 6 hour post extubation, when compared to BC group of 6.03 ± 0.669 in 1 hour reduced to 4.17 ± 0.699 at 6 hour post extubation.

Dexmedetomidine combination significantly reduced the total dose of rescue analgesic required in 24 hours as compared to Clonidine combination.
Anaesthetic management of pregnant patients with severe dengue fever for emergency caesarean section - A case series and review
Authors: Chatterjee Ranajit , Joshi Nandita , Gupta Lalit
Published: September 2023

: Dengue, a mosquito-borne viral infection, can lead to severe complications like dengue shock syndrome and severe thrombocytopenia. Pregnant patients with dengue present unique anaesthetic challenges. In this case series, we present the anaesthetic management of four pregnant patients with dengue who required emergency caesarean delivery.

: All patients had severe thrombocytopenia and required platelet transfusions. Two patients developed respiratory distress and pulmonary edema in the perioperative period. One patient had severe liver function abnormalities along with thrombocytopenia, complicating the diagnosis. All patients received intensive care unit (ICU) management. None of the neonates tested positive for dengue.

: The pathophysiological changes of pregnancy and dengue infection complicate the anaesthetic management of critically ill dengue patients. Thrombocytopenia and abnormal immune response lead to acute vascular permeability, plasma leakage, circulatory insufficiency, and polyserositis. Abnormal liver function tests and thrombocytopenia must be differentiated from HELLP syndrome. Over-transfusion of fluids due to shock can lead to pulmonary edema.

: Pregnant patients with dengue fever pose a high risk of maternal and foetal mortality and morbidity. Successful anaesthetic management requires judicious transfusion of blood products and fluids based on the disease's complications and stage of illness. General anaesthesia is safe in these patients.
History of the development of the environmental movement in Russia: political aspects
Authors: Skipin Nikolai
Published: September 2023

This article provides a retrospective analysis of the formation of environmental policy and the formation of the "green" political movement in Russia from the 1960s until today. The study is based on the classification of the stages of development of the domestic "green" movement, proposed by O.N. Yanitsky. The authors describe four stages in the development of the domestic environmental movement: from its inception to the crisis. The purpose of the work is to supplement the proposed by Yanitsky’s classification of a new stage in the development of “green” Russia: the article shows that this stage is associated with the creation of patriotic environmental youth non-profit organizations, as well as with the subsequent actions of the authorities, who see their own promising directions in this. In conclusion, a forecast is given that the way out of the crisis of the "green" movement in Russia is associated with the need to institutionalize the movement, in particular, to create a "green" faction in the State Duma in the future.
Synergistic effect of Dactolisib/Lys05 combination on autophagy in A549 cells
Authors: Abdelwahab Mohammad , Saeed Hesham , Elnikhely Nefertiti , Nematalla Hisham
Published: September 2023

Effective therapeutic strategies are urgently required to enhance the prognosis of patients suffering from KRAS mutations. Owing to the undruggable nature of KRAS, targeting downstream signaling pathways, namely PI3K/AKT/mTOR, shows antiproliferative and apoptotic effects. Unfortunately, targeting this pathway upregulates autophagy, contributing to reduced drug efficacy. Therefore, it was reasonable to use a combination of kinase inhibitors and autophagy inhibitors to achieve a higher therapeutic benefit. The impact of Dactolisib, a dual PI3K/mTOR inhibitor, and Lys05, a dimeric chloroquine, was tested on the survival of breast cancer MCF-7 and lung cancer A549 cells. The dose selection for the optimal effect of the Dactolisib/Lys05 combination was determined using CompuSyn software. This combinatorial effect was evaluated using various methodologies, such as expression profile analysis for autophagic, proliferative, and apoptotic markers. These effects were corroborated by ELISA, Western blot, and flow cytometry using the Annexin V-FITC apoptosis detection kit. A549 cells treated in a 2:1 ratio of Lys05 and Dactolisib demonstrated a synergistic effect on cell death, proliferation, and apoptotic gene markers, in addition to its effect on autophagic gene and protein markers, showing an enhanced effect compared to monotherapy. Therefore, the PI3K/AKT kinase inhibitor/autophagy inhibitor combination establishes higher therapeutic benefits on A549 cells compared to kinase inhibitor monotherapy.
Criteria analysis for kinetics curves of initiated blood serum chemiluminescence
Authors: Oliynyk Iryna
Published: September 2023

The chemiluminescence (CL) methods unlike the other methods of determining free radicals (FR) allow investigating the kinetics of the derivation and recombination of radicals/antioxidants, and thus the development and attenuation of the process/processes after excitation in time. However, these methods are of limited application because the knowledge of the explored parameters is insufficient (maximum intensity and integrated area under the kinetics plot). The kinetics is studied by the CL methods and a new parameter (IR-criterion) of analysis of damping of the initiated CL dynamics has been introduced. The IR-criterion parameter: identifies the relationship between the rates of initiation and recombination of peroxide radicals in blood-serum samples; allows the full straightening of the CL curves; provides new information in the considered pathological processes; can serve as an additional universal characteristic of FR activity of blood serum in pathological processes.
In silico explorations of bacterial mercuric reductase as an ecofriendly bioremediator for noxious mercuric intoxications
Authors: Naveed Muhammad , Shabbir Muhammad Aqib , Aziz Tariq , Saleem Ayesha , Naveed Rida , Khan Ayaz Ali , Ul Haq Taqweem , Alharbi Metab , Alshammari Abdulrahman , Alasmari Abdullah F.
Published: September 2023

Mercury is a major pollutant in the environment due to its high concentration in the soil. In this study, a mercuric reductase was extracted from Pseudomonas aeruginosa. The sequence of the enzyme was retrieved from the literature and structural homologs were identified. The protein bonded with Mercuric compounds and their interaction was briefly studied. Autodock Vina was used to perform a molecular docking with the target protein. Results showed that the sequence consists of most of the random coil 44.74% followed by α-helix and B-turns. Moreover, the protein was predicted to have a FAD/NAD(P)-binding domain. The virulence factor prediction using different approaches of Virulentpred and VICMpred suggested that P00392 is non-toxic. Next, the mutational analyses were performed to predict the active site residues in the resulting models and to determine mutants. The results show that the enzyme is involved in the bioremediation of mercury by using in-silico techniques. Finally, molecular docking studies were conducted on the best-selected model to find the active site residues and to generate a pattern of interaction to understand the mode of action of the substrate and its catalytic activity which refers to the binding with mercury.
“Konuşuyosak Ne Yababiliriz Kardeşim”: Twitter’da Konuşan Hayvanlar ve Türler Arası Yakınlık
Authors: DİŞLİ Semra Özlem
Published: September 2023

Sosyal medya, günümüz iletişim ve ilişki biçimlerinde önemli bir yer tutmaktadır. Bu çalışma ise, sosyal medyada insan ve hayvan ilişkilerini incelemek üzere odağa alınmıştır. Bu bağlamda sosyal medya ağlarından Twitter, sahiplerinin kendi ev hayvanları adına oluşturdukları profiller ile öne çıkar. Çalışmaya da temel teşkil eden bu profillerin en dikkat çekici özelliği, buradaki hayvanların konuşturulmaları veya literatürde yer aldığı şekli ile bu profillerin “konuşan hayvanlara” ait olmasıdır. Çalışma kapsamında toplamda 19 Twitter konuşan hayvan profili ve bu profillerin 2021 ile 2022 yıllarına ait gönderileri incelenmiştir. İncelenen bu profillerde hayvanlar, kendilerine özgü bir üslup ile gündelik pratiklerini, insanlar ve diğer hayvanlar ile ilişki biçimlerini, duygu ve düşüncelerini anlatmaktadırlar. Bu yolla, insanlar ve hayvanlar arasındaki ilişkilerde etki yaratmayı hedefleyen bir anlatı inşa edilmektedir. Bu anlatıyı adlandırmak üzere “türler arası yakınlık” ifadesi kullanılmıştır. İnsan ve hayvanı birbirinden bağımsız iki ayrı varoluş olarak ele alan yerleşik yaklaşımların aksine türler arası yakınlık, bu ikisi arasındaki sürekliliği, yakınlığı ve etkileşimi vurgular. Twitter konuşan hayvan profillerinin inşa ettiği türler arası yakınlık anlatısının temelinde de hayvan öznelliğinin tanınması yer almaktadır. Hayvan öznelliği ise, hayvanların “neredeyse insan ama tamamen değil” olarak betimlenmesine dayanır. Twitter konuşan hayvan profillerini dil, gündelik hayat, sosyal çevreye üyelik ve duygular bağlamında inceleyen bu çalışma, hayvanlara yönelik anlamlandırma ve değerlendirmeler ile insan-hayvan ilişkileri üzerine düşünmeyi amaçlamaktadır.
An Example of Using Collaborative Online International Learning for Petroleum and Chemical Engineering Undergraduate Courses
Authors: Durand Helen , Balhasan Saad
Published: September 2023

This work describes an international collaboration experience carried out between our process design and petroleum property evaluation courses. This collaboration was developed as part of a partnership between the American University of Ras Al Khaimah (AURAK) in Ras Al Khaimah, United Arab Emirates, and Wayne State University in Detroit, Michigan, United States of America, using a program called Collaborative Online International Learning (COIL) from the State University of New York (SUNY) system. The COIL program provides training to faculty on engaging students in international and cross-disciplinary projects to promote skills needed in the current work force. The COIL training meetings facilitated pairing faculty of different disciplines in different parts of the world and provided a structure for developing a collaborative project. The collaborative project that we undertook in fall 2021, and which we detail throughout this article, was titled Upstream and Downstream of Petroleum Economics.
EFFECTIVENESS ANALYSIS OF ELECTROTOMOGRAPHY SOFTWARE SYSTEMS FOR FIELD DATA INTERPRETATION IN SEISMICALLY ACTIVE AREAS (USING THE EXAMPLE OF THE GORNY ALTAI)
Authors:   A. A. Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Novosibirsk, Russia, Shaparenko I. O. , Nevedrova N. N. ,   A. A. Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Novosibirsk, Russia, Marinenko A. V. ,   A. A. Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Novosibirsk, Russia, Surodina I. V. ,   A. A. Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Novosibirsk, Russia
Published: September 2023

Since 2004, regular investigations with the use of electrical exploration methods have been conducting by researchers of Institute of Petroleum Geology and Geophysics SB RAS on the territory of the Gorny Altai. The electrotomography method is used to construct geoelectric models of the upper section part to depths of several tens of meters. One of the important tasks of this method is to determine characters of fault zones. Large regional Cenozoic faults are distinguished by significant shifts and are usually well manifested in relief. Intradepression interblock faults overlaid by sedimentary deposits are hard to identify by geological methods, but they are reflected mainly by zones with a reduced value of electrical resistance in sections according to electrotomography data. The paper considers practical examples of the ET method use for studying fault structures of the Gorny Altai. Analysis of the accumulated volume of electrotomography field data allowed researchers to compile typical models simulating the fault structures of this territory. The results of simulated data inversion obtained by numerical modeling of fault zones of the Gorny Altai using well-known third-party programs and proprietary developments are compared. The capabilities of different software systems are analyzed for interpretation of electrotomography data.
FORMS OF MIGRATION OF CHEMICAL ELEMENTS IN RADON WATERS IN THE SOUTH OF SIBERIA
Authors:   Novosibirsk State University, Novosibirsk, Russia, Nikitenkov A. N. ,   A.A.Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Novosibirsk, Russia,   National Research Tomsk Polytechnic University , Tomsk, Russia, Novikov D. A. ,   Novosibirsk State University, Novosibirsk, Russia,   A.A.Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Novosibirsk, Russia, Korneeva T. V. ,   Novosibirsk State University, Novosibirsk, Russia,   A.A.Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Novosibirsk, Russia
Published: September 2023

The paper presents the first results of thermodynamic modeling of the chemical elements migration forms in radon waters of southern Siberia. It was determined that Ca, Mg, Na, K, Mn, as well as, Fe (at nearneutral pH) migrates in the form of free ions, the proportion of which in most cases is more than 90%. Among the complex forms of migration of trace elements, as well as U and Th, associates prevail with a participation of dominant anions HCO3 –, CO3 2–, compounds with Cl– ions are less common. Hydroxide and oxide coordination compounds play a significant role in the migration of Al, as well as Si, U and Th (reaching tens of % of gross content). In oxidizing environment, uranium migrates predominantly in the form of carbonate compounds, in a reducing environment – in the form of oxides and hydroxide ions. The proportion of samples with hydroxide forms decreases with an increase in pH value by more than 8.5, and the proportion of oxide forms increases. Thorium in the studied radon waters migrates mainly in the form of carbonate compounds, namely in the form of (ThCO3(OH)3)–, which accounts for more than 90% in most samples. Its decrease to values of about 60% is typical for slightly acidic waters with a pH of less than 6.5.
Crack the rock: the role of coronary lithotripsy for heavy calcified lesions
Authors: Sciahbasi Alessandro , Minardi Simona
Published: September 2023

Since the first balloon angioplasty 40 years ago, percutaneous coronary interventions (PCI) applicability continues to expand, even in the context of complex coronary anatomies, previously considered unsuitable for PCI. A very challenging scenario for PCI is the treatment of heavily calcified coronary stenosis that is associated with early complications and late adverse events. Countless tools and techniques have been introduced to treat calcified coronary stenosis, and among these, a new and promising technique obtained from lithotripsy technology employed for the treatment of uretero-renal calculi has been introduced: the intravascular lithotripsy (IVL). IVL utilizes acoustic shockwaves in a balloon-based delivery system that induces calcium fractures, facilitating stent advancement and expansion. This review aims to describe the device used for IVL, the results of clinical studies published, and the possible clinical use.
HOMENS DE ARMAS E NEGÓCIOS: A TRAJETÓRIA DOS MERCADORES MIGUEL FERNANDES E MIGUEL GOMES BRAVO ENTRE AS DEFESAS ATLÂNTICAS E A CONQUISTA DE SERGIPE D’EL-REY (1587 – 1590)
Authors: Vergetti de Menezes Mozart , Medeiros Brandão Maria Eduarda de
Published: September 2023

A expansão ibérica foi marcada por guerras e comércio, provocando diferentes formas de beligerância no Atlântico e contribuindo para que europeus, africanos e indígenas guerreassem como rivais e aliados. Dentre os grupos envolvidos estiveram os mercadores, permitindo que suas experiências sejam concebidas através das propostas sobre descortinar a face dos combatentes nos conflitos (KEEGAN, 2000). Intenciona-se assim, utilizar uma abordagem microanalítica para investigar a trajetória de dois mercadores cristãos-novos na defesa da Bahia, dos Açores e na conquista de Sergipe, através de um processo inquisitorial e documentos referentes às tropas hispânicas – questionando como as guerras e o comércio impactaram suas vidas, mercancias e evidenciando práticas comerciais em meio aos conflitos.
DAS TERRAS DO UNA À CORTE: ZACARIAS DE GÓIS E VASCONCELOS, UM ANTI-PODER MODERADOR NO SÉCULO XIX
Authors: Souza Amorim Antonio Jorge
Published: September 2023

Advogado, legislador, ministro e presidente de províncias, Zacarias de Góis e Vasconcelos teve sua vida e pensamento devassados por variada literatura. Nosso propósito aqui é tê-la como esteio para analisar o papel do notório Conselheiro Zacarias durante o século XIX com o fim de compreender a sua relevância quanto a defesa da limitação da centralidade do poder Moderador. Além disso, realçar a história local integrada à história estadual, nacional e geral é tarefa deste trabalho científico, que busca ainda trazer à importância a biografia histórica como viés historiográfico.
FONTES DA TRADIÇÃO NACIONALISTA SOBRE AS “INVASÕES HOLANDESAS”: O USO DAS NARRATIVAS DA “GUERRA BRASÍLICA” POR FRANCISCO ADOLFO DE VARNHAGEN
Authors: De Carvalho Ribeiro da Costa Regina
Published: September 2023

No século XIX, Francisco Adolfo de Varnhagen participou do projeto de construção nacional do Instituto Histórico e Geográfico Brasileiro. O objetivo do presente artigo é analisar o uso das crônicas da “guerra brasílica” como fontes históricas por Varnhagen, na obra História das Lutas com os Holandeses no Brasil, para construir uma interpretação sobre as “invasões holandesas” que se tornou paradigmática dentro da tradição nacionalista sobre a História do Brasil. O debate parte da identificação desta tradição nacionalista, avança na caracterização do paradigma das “invasões holandesas” e termina com o exame das fontes do historiador oitocentista, particularmente os relatos de Duarte de Albuquerque Coelho, Manoel Calado e Francisco de Brito Freire, mais referenciados por Varnhagen.
IMAGENS DE MULHERES INDÍGENAS NO LIVRO DIDÁTICO: UMA ABORDAGEM DECOLONIAL
Authors: Lúcia Caixeta Vera , Leda de Arruda Daniel
Published: September 2023

Este artigo tem como objetivo analisar as imagens das mulheres indígenas presentes na Coleção didática de História “Geração Alpha” do 7º ano do Ensino Fundamental (2020-22). Partindo da perspectiva da Decolonialidade foi mobilizado os conceitos de “colonialidade do gênero” e de “colonialidade do poder/ser/saber” a fim de analisar duas imagens para entender os discursos, as representações, as simbologias e significados presentes no processo de (in)visibilidade dos povos indígenas, e em específico, das mulheres indígenas, nos textos visuais. As análises foram realizadas a partir da metodologia de autores da Semiótica, levantando pontos em relação à figuratividade e quadrado semiótico. Como resultado, identificamos, a partir da análise realizada, que mesmo numa coleção atual, ainda se faz presente uma invalidação da existência das mulheres indígenas, comprometendo o protagonismo desses povos no ensino de História.
TERRITÓRIOS DE RESISTÊNCIAS: UMA ANÁLISE DO DOCUMENTÁRIO “TOCANTINS RIO AFOGADO” (2005)
Authors: Desidério Plábio Marcos Martins , Pereira da Silva Diogo , Queiroz dos Santos Gabriel
Published: September 2023

O presente artigo tem por objetivo analisar as narrativas de povos ribeirinhos presentes no documentário “Tocantins, Rio Afogado”, de Hélio Brito e José Luiz Neiva Brito. Foi destacado a fala de alguns ribeirinhos, afim de criar as categorias de análises: a) angústia: a palavra da gente não vale coisa nenhuma; b) os impactos nas duas terras: a boa e a ruim; c) sentimentos e descrenças. Assim, a partir da teorização de Haesbaert (2005) sobre território e territorialidade, buscou-se investigar, por meio das vozes dos atingidos, os sentimentos de pertencimento, de formação identitária com os locais (cidades) atingidos pela construção das Usinas Hidrelétricas ao longo do rio Tocantins. Nesse sentido, sob ótica do teórico Nichols (2007) o documentário é analisado a partir da representação social, conceito utilizado pelo autor para imprimir uma categoria fílmica à produção, sendo a representação de experiências vividas pelos personagens. Com isso, vislumbrou-se sentimento de perda, negação do direito de escolher viver nos locais de origem e a pergunta que ecoa no consciente e inconsciente dos ribeirinhos: Progresso para quem?
QUERELA SOBRE OS MARES: AS DISPUTAS ENTRE PAISES BAIXOS E PORTUGAL NO CONTEXTO DA ERA FILIPINA, NA TESE “DO JUSTO IMPÉRIO ASIÁTICO DOS PORTUGUESES ” DE SERAFIM FREITAS (1609-1625)
Authors: Szlachta Junior Arnaldo Martin , Menezes Sezinando Luiz , Borges Felipe Augusto Fernandes
Published: September 2023

O presente trabalho busca demonstrar os argumentos do Jesuíta Serafim Freitas em sua tese “Do justo Império asiático dos portugueses” (1625) que ficou conhecida também como Mare clausum que se trata de resposta ao documento Mare Liberum (1608) do jurista holandês Hugo de Grotius, que destaca a liberdade sobre os mares para todas as nações. Freitas usará de argumentos da fé, das leis romanas e de uma lógica renascentista para provar que os portugueses é que seriam os senhores do mar. Para esse artigo, focamos na análise dos quatro primeiros capítulos da tese de Freitas, na qual são exaltados os feitos portugueses como argumentos.
CULTURA MATERIAL ENQUANTO RESULTANTE E LEGITIMADORA DA ORDEM SOCIAL ESTABELECIDA NA SOCIEDADE AÇUCAREIRA DA ZONA DA MATA SUL PERNAMBUCANA
Authors: Santana Eduardo Augusto de
Published: September 2023

Este texto busca trazer algumas considerações acerca da cultura material implantada na Mata Sul pernambucana e como a sua arquitetura refletia as relações de poder e dominação estabelecidas pelos grupos sociais dominantes do mundo açucareiro. Se propondo, desta maneira, a problematizar as representações simbólicas que as imagens daquelas construções endossavam naquela sociedade. Destarte, este trabalho se propõe a discutir a relação simbólica entre a cultura material implantada naquela região, entre os séculos XVI e o XVIII, e as formas pelas quais os grupos dominantes se organizavam, para legitimar o seu poder frente à sociedade da época a partir da manipulação simbólica daquelas construções no passado.
Protection of Intellectual Property Rights in the Perspective of Islamic Law
Authors: Ratnawati Erna Tri Rusmala , Al Farizi Rizqi Samera
Published: September 2023

This article analyses the protection of intellectual property rights from the perspective of Islamic law. This article examines intellectual property rights by analyzing the concepts of wealth, rights, and ownership in Islamic law. This study employs a normative research method. The approach utilized in this research includes statutory and conceptual approaches. The data used in this study encompassed secondary data derived from primary, secondary, and tertiary legal materials. The research findings reveal that most scholars categorize intellectual property rights as a form of wealth, thereby subjecting it to similar treatment and legal consequences as other forms of wealth. Intellectual property rights constitute movable wealth, are permissible for utilization, lack a standardized market unit, and maintain their value even when exploited. Consequently, intellectual property can be transacted for profit and safeguarded by assessing its value when compensating for any loss. When acquired or discovered through means that adhere to Islamic law, intellectual property becomes a permissible right to possess. However, the ownership of these intellectual property rights under Islamic law remains constrained by Sharia principles.