bluuebunny/crossref_metadata_2025 huggingface dataset:
In-Hospital Mortality from Spondylodiscitis: Insights from a Single-Center Retrospective Study
Authors: Joerger Ann-Kathrin , Albrecht Carolin , Lange Nicole , Meyer Bernhard , Wostrack Maria
Published: November 2023

(1) Background: There is a marked proportion of spondylodiscitis patients who die during the early stage of the disease despite the applied therapy. This study investigates this early mortality and explores the associated risk factors. (2) Methods: We conducted a retrospective analysis of spondylodiscitis patients treated at our Level I spine center between 1 January 2018 and 31 December 2022. (3) Results: Among 430 patients, 32 (7.4%) died during their hospital stay, with a median time of 28.5 days (range: 2.0–84.0 days). Six of these patients (18.75%) did not undergo surgery due to dire clinical conditions or death prior to scheduled surgery. Identified causes of in-hospital death included multiorgan failure (n = 15), acute bone marrow failure (2), cardiac failure (4), liver failure (2), acute respiratory failure (2), acute renal failure (1), and concomitant oncological disease (1). In a simple logistic regression analysis, advanced age (p = 0.0006), diabetes mellitus (p = 0.0002), previous steroid medication (p = 0.0279), Charlson Comorbidity Index (p < 0.0001), and GFR level at admission (p = 0.0008) were significant risk factors for in-hospital death. In a multiple logistic regression analysis, advanced age (p = 0.0038), diabetes mellitus (p = 0.0002), and previous steroid medication (p = 0.0281) remained significant. (4) Conclusions: Despite immediate treatment, a subset of spondylodiscitis patients experience early mortality. Particular attention should be given to elderly patients and those with diabetes or a history of steroid medication, as they face an elevated risk of a rapidly progressing and fatal disease.
Role and Morbidity of Protective Ileostomy after Anterior Resection for Rectal Cancer: One Centre Experience and Review of Literature
Authors: Coco Claudio , Tondolo Vincenzo , Amodio Luca Emanuele , Pafundi Donato Paolo , Marzi Federica , Rizzo Gianluca
Published: November 2023

The creation of a protective stoma is considered a valid life-saving tool, significantly reducing the effects of anastomotic leakage in terms of related morbidity, mortality, and reoperation rate. The aim of this study was to evaluate the impact of a protective loop ileostomy in terms of short- and long-term postoperative morbidity, quantifying the stoma-related complications arising after stoma creation and stoma closure and the risk of permanent stoma. From January 2009 to January 2020, 149 patients with rectal cancer treated by anterior resection and protective ileostomy were enrolled in the study. A total of 113 (75.84%) patients were preoperatively treated with neoadjuvant radiochemotherapy. A clinically relevant anastomotic leak occurred in two patients (1.34%). The postoperative stoma complication rate was 6%. According to the Clavien classification, the stoma-related complication grade was I in seven patients (4.7%) and II in two patients (1.3%). A late stoma-related parastomal hernia occurred in one patient (0.67%). In 129 patients (86.57%), it was possible to close the stoma. Postoperative complications of stoma closure occurred in 12 patients (9.3%). The stoma closure complication grade was I in seven cases (5.43%), II in two cases (1.55%), and ≥3 in three cases (2.33%). Incisional hernia was the only late complication recorded in seven cases (5.42%). The permanent stoma rate was 13.43%. A protective ileostomy has a nonnegligible complication rate, but the rate of severe complications is low. Every effort should be made to clearly identify patients in whom the risk of anastomotic leakage justifies the stoma.
Sex-Specific Disparities in Outcomes of Transcatheter Edge-to-Edge Repair for Mitral Regurgitation: A Multicenter “Real-World” Analysis
Authors: Ausbuettel Felix , Barth Sebastian , Chatzis Georgios , Sassani Kiarash , Fischer Dieter , Weyand Sebastian , Mueller Julian , Schuett Harald , Schieffer Bernhard , Luesebrink Ulrich , Waechter Christian
Published: November 2023

Background: mitral regurgitation (mr) is the most common valvular heart disease (vhd) in the elderly and tends to be more prevalent in women. while relevant sex differences in outcomes are evident in surgically treated collectives, there are very limited and conflicting sex-specific data for the growing cohort of patients undergoing transcatheter edge-to-edge repair (teer). Objective: to investigate whether sex impacts procedural safety and efficacy, and in-hospital- and long-term outcomes, after teer for mr. Methods: in a multicenter observational cohort study, patients who underwent teer were stratified by sex and relevant outcome measures, and analyzed using multivariable cox regression and propensity score matching (psm). Results: a total of 821 patients were analyzed, of whom 37.4% (307/821) were female. compared to male patients, females were significantly older (77 ± 8.5 vs. 80.4 ± 6.7 years, p = 0.03), and had less coronary artery disease (cad, 67.7% vs. 53.1%, p < 0.0001) and a higher proportion of preserved left ventricular function (lvef > 50%, 32.5% vs. 50.5%, p > 0.0001). safety and efficacy of the teer procedure and in-hospital mortality did not differ between the sexes. after psm, women showed significantly better survival 3 years after teer compared to men (60.7% vs. 54.2%, p = 0.04) and a lower risk of all-cause death according to multiple cox regression (hr 0.8, 95% ci 0.6–0.9, p = 0.02). after sex-specific stratification for concomitant atrial fibrillation (af), the most common comorbidity in the present collective, women with af experience significantly worse adjusted survival compared to women without af (53.9% vs. 75.1%, p = 0.042) three years after teer and lose the survival advantage over men. Conclusions: female patients are older and less comorbid than males undergoing TEER. The TEER procedure is equally safe and effective in both sexes. While in-hospital mortality did not differ, female patients experienced a significantly better adjusted long-term survival compared to male patients. Concomitant AF offsets the prognostic advantage of females over males and, in contrast to males, significantly impairs long-term survival in women undergoing TEER. Further research is warranted to elucidate underlying causes for the observed sex disparities and to develop sex-tailored treatment recommendations.
Effects of Two Different Self-Paced Training Modalities on the Aerobic Fitness Levels, Psychophysiological Responses, and Antioxidant Status in Physically Active Young Adults
Authors: Soylu Yusuf , Krustrup Peter , Mohr Magni , Arslan Ersan , Kilit Bulent , Radzimiński Łukasz
Published: November 2023

This study aims to investigate the effects of self-paced high-intensity interval training (Sp-HIIT) vs. self-paced moderate-intensity continuous training (Sp-MICT) on aerobic fitness levels, psychophysiological responses, and antioxidant status to assess the relationship between aerobic fitness levels and antioxidant markers. Physically active young adults were randomised into Sp-HIIT and Sp-MICT groups. The intervention consisted of three weekly sessions during an eight-week period. Sp-HIIT consisted of performing two sets of 12–24 × 30 s high-intensity runs ≥ 85% HRmax followed by 30 s rest periods, while Sp-MICT consisted of performing 24–48 min of continuous running at 60–75% HRmax. Pre- and post-intervention testing included a maximal oxygen uptake (VO2max) assessment during a 30-15 intermittent fitness test (30-15 IFT), as well as resting blood samples, which were analysed for oxidative stress markers (malondialdehyde (MDA)) and activity of intracellular antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD) and reduced (GSH) and oxidized glutathione (GSSG)). The Sp-HIIT group showed a greater improvement in velocity of 30-15 IFT, VO2max, and MDA responses. Furthermore, the Sp-HIIT group demonstrated higher psychophysiological responses than the Sp-MICT group, except for anger responses. In conclusion, these results suggest that Sp-HIIT has a higher level of beneficial exercise-induced effects in physiological responses with greater perceived exertion in physically active young adults.
The Advantages of Next-Generation Sequencing Molecular Classification in Endometrial Cancer Diagnosis
Authors: Rivera Daniela , Paudice Michele , Accorsi Giulia , Valentino Floriana , Ingaliso Marta , Pianezzi Ada , Roggieri Paola , Trevisan Lucia , Buzzatti Giulia , Mammoliti Serafina , Barra Fabio , Ferrero Simone , Cirmena Gabriella , Gismondi Viviana , Vellone Valerio Gaetano
Published: November 2023

Endometrial cancer (EC) is the most frequent gynecological cancer. The ESGO/ESTRO/ESP 2020 guidelines identify prognostic groups based on morpho-molecular characteristics. This study aims to evaluate the clinical applicability of NGS analysis to define an appropriate risk class and to improve the diagnostic and prognostic stratification of ECs. Cases of serous carcinoma (OHEC) and high- (HGEC) and low-grade (LGEC) endometrioid carcinoma diagnosed with the morphological and immunohistochemical (IHC) protocols were considered. After a standardized pre-analytical phase, tumor DNA was semi-automatically extracted and analyzed using NGS with a panel of 14 genes. A total of 63 cases were considered. NGS analysis was successful in 60 cases; all of these were classified according to the new diagnostic algorithm. The molecular risk classification showed a good correlation with the morphological (k = 0.8). The study showed that the protocols of the pre-analytical and analytical phases used are robust and can lead to molecular results that fall within the standards required, which can be used in clinical practice for more precise diagnostic–therapeutic management of patients. The implementation of the classification is particularly relevant for better prognostic stratification of HGECs. In addition, the identification of a suspicious VUS in POLE questions the classification of truncating variants.
Correlation between Ankle Imaging Findings and Self-Reported Outcomes: A Longitudinal Assessment in Patients with Tibiofibular Diastasis
Authors: Hosin Samer , Vermesan Dinu , Deleanu Bogdan , Pop Daniel , Crisan Dan , Al-Qatawneh Musab , Mioc Mihai , Faur Cosmin , Rosca Ovidiu , Prejbeanu Radu
Published: November 2023

Background and Objectives: This longitudinal study investigated the correlation between imaging findings and self-reported questionnaire outcomes in patients with tibiofibular diastasis, exploring the effects of surgical screw removal versus conservative treatment. This study was conducted at “Victor Babes” University of Medicine and Pharmacy in Timisoara between 2018 and 2023. Materials and Methods: The study involved 85 patients in the screw removal group and 44 in the conservative group, assessed at 2 and 6 months post-surgery, answering the SF-36, HADS, and WHOQOL questionnaires. Results: Significant differences were observed at 2 months post-surgery, with the screw removal group showing lower shear wave velocities in ankle dorsiflexion (8.9 ± 1.4) and anterior talofibular ligament (2.8 ± 0.9), indicating better mobility compared to the conservative group (ankle dorsiflexion: 10.1 ± 1.8, ATFL: 3.2 ± 1.1). Radiographically, lower tibiofibular overlap (8.1 ± 2.1) in the screw removal group suggested improved joint fixation quality. These physical improvements were mirrored in the quality-of-life assessments, where the screw removal group reported higher physical health scores on the SF-36 survey at 2 months, a trend that continued at 6 months. At 2 months, ankle dorsiflexion demonstrated a strong negative correlation with the SF-36 Physical score (r = −0.417) and WHOQOL Physical domain (r = −0.394), and a positive correlation with HADS Anxiety (r = 0.312). Similarly, ATFL and CFL velocities negatively correlated with the SF-36 Physical score (ATFL: r = −0.251; CFL: r = −0.237). Radiographic tibiofibular overlap and clear space positively correlated with WHOQOL Physical domain (TOL: r = 0.291; TCS: r = 0.276), with TCS also negatively correlating with HADS Anxiety (r = −0.228). At 6 months, these correlations persisted, with notable negative correlations between ultrasound ankle dorsiflexion and both SF-36 Physical score and WHOQOL Physical domain. Conclusions: These findings underscore the advantages of screw removal in enhancing physical recovery and reducing anxiety in the short term, while indicating similar long-term mental health outcomes between treatment approaches.
Four New Species of Strobilomyces (Boletaceae, Boletales) from Hainan Island, Tropical China
Authors: Deng Hui , Wang Yi , Lei Jin-Rui , Chen Zong-Zhu , Liang Zhi-Qun , Zeng Nian-Kai
Published: November 2023

Strobilomyces, one of the most noticeable genera of Boletaceae (Boletales), is both ecologically and economically important. Although many studies have focused on Strobilomyces in China, the diversity still remains incompletely understood. In the present study, several collections of Strobilomyces from Hainan Island, tropical China were studied based on morphology and molecular phylogenetic analyses. Four species are described as new, viz. S. baozhengii, S. conicus, S. hainanensis, and S. pachycystidiatus. Detailed descriptions, color photos of fresh basidiomata, and line drawings of microstructures of the four species are presented.
Preventing Dementia—A Cross-Sectional Study of Outpatients in a Tertiary Internal Medicine Department
Authors: Sandu Ioana-Alexandra , Ștefăniu Ramona , Alexa-Stratulat Teodora , Ilie Adina-Carmen , Albișteanu Sabinne-Marie , Turcu Ana-Maria , Sandu Călina-Anda , Alexa Anisia-Iuliana , Pîslaru Anca-Iuliana , Grigoraș Gabriela , Ștefănescu Cristinel , Alexa Ioana-Dana
Published: November 2023

Dementia is a significant health problem worldwide, being the seventh leading cause of death (2,382,000 deaths worldwide in 2016). Recent data suggest there are several modifiable risk factors that, if addressed, can decrease dementia risk. Several national dementia screening programs exist; however, limited-income countries do not have the means to implement such measures. We performed a prospective cross-sectional study in an outpatient department to identify individuals at risk for dementia. Patients with no known cognitive dysfunction seeking a medical consult were screened for dementia risk by means of the cardiovascular risk factors, ageing, and dementia (CAIDE) and modified CAIDE tests. Additionally, we collected demographic and clinical data and assessed each participant for depression, mental state, and ability to perform daily activities. Of the 169 patients enrolled, 63.3% were identified as being in the intermediate-risk or high-risk group, scoring more than seven points on the mCAIDE test. Over 40% of the elderly individuals in the study were assessed as “somewhat depressed” or “depressed” on the geriatric depression scale. Almost 10% of the study population was diagnosed de novo with cognitive dysfunction. In conclusion, using a simple questionnaire such as the mCAIDE in a predefined high-risk population is easy and does not represent a major financial burden. At-risk individuals can subsequently benefit from personalized interventions that are more likely to be successful. Limited-resource countries can implement such screening tools in outpatient clinics.
Fossil Fuel-Based versus Electric Vehicles: A Volatility Spillover Perspective Regarding the Environment
Authors: Rastogi Shailesh , Kanoujiya Jagjeevan , Singh Satyendra Pratap , Doifode Adesh , Parashar Neha , Tejasmayee Pracheta
Published: November 2023

Due to environmental concerns, electric vehicles (EVs) are gaining traction over fossil fuel-based vehicles. For electronic devices, including vehicles, copper is the key material used for building. This situation draws attention to the impact of copper prices, crude oil prices, and exchange rates on the economic viability of using EVs over fossil fuels. We use the volatility spillover effect (VSE) to determine the financial viability of these two types of vehicles in the context of environmental issues. Daily data on copper prices, crude oil, exchange rate, and the BSE100 ESG (“Bombay Stock Exchange 100 Environmental, Social and Governance”) index are taken from 1 November 2017 to 20 September 2022. Two popular multivariate GARCH (“Multivariate Generalized Autoregressive Conditional Heteroscedasticity”) family models, i.e., the BEKK (“Baba–Engle–Kraft–Kroner”)-GARCH (BG) and DCC (“Dynamic Conditional Correlation”)-GARCH (DG) models, are utilized to find volatility connections between these variables. These are appropriate GARCH models to observe the volatility dependence of one market on another market. It is found that there exist volatility effects of copper and exchange rate on the S&P BSE100 ESG Equity Index Price, which we will refer to here as ESG. However, crude oil is found to be insignificant for ESG. The novelty of this study is in the use of volatility spillover to determine economic viability. The volatility effects of copper prices are positive for ESG in the short run and negative for long-term volatility. The exchange rate has a positive volatility effect on ESG in the long run. Surprisingly, we find that EVs are technologically better than fossil fuel-based vehicles as a possible sustainable energy source. We observe studies that have raised similar concerns about EVs’ lack of business sense compared to fossil fuels. However, using VSE to explore financial viability offers a fresh perspective. Based on the findings of the current study, it is recommended that policymakers and researchers revisit their support for EVs as an alternate and sustainable source of energy.
The Motivational Utility of Knowledge: Examining Fundamental Needs in the Context of Houselessness Knowledge
Authors: Watanabe Micah , McNamara Danielle S.
Published: November 2023

Past research on knowledge has differentiated between dimensions (e.g., amount, accuracy, specificity, coherence) of knowledge. This paper introduces a novel dimension of knowledge, the Motivational Utility of Knowledge (MUK), that is based on fundamental human needs (e.g., physical safety, affiliation, actualization, reproduction). Adults in the United States (N = 190) were recruited from an online survey platform and paid for participation. Participants read a set of four texts arguing different views of houselessness and were administered a comprehension test after each text. Participants were asked about their conceptions of houselessness before and after reading. Finally, they were given the MUK scale, a demographics questionnaire, including questions about their personal experience with houselessness, and were administered a general prior knowledge test and a vocabulary knowledge test. We examined MUK, the factor structure of the scale and the relationship between MUK and other measures of knowledge. The analyses showed that the subscales of MUK loaded onto a single factor—an overall value of houselessness knowledge. In addition, we found that MUK was correlated with conceptions of houselessness and comprehension of texts on houselessness, indicating that the scale was valid. Overall, the findings demonstrate that MUK is an important dimension of knowledge to consider in learning tasks.
A Rare Case of Pulmonary Embolism, Deep Vein Thrombosis, Bilateral Avascular Necrosis of the Femoral Head, and Miscarriage following COVID-19 in a Patient with Multiple Genetic Coagulation Factor Deficiency—A Case Report
Authors: Ivanova Nevena Georgieva
Published: November 2023

The coronavirus disease (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The most common symptoms of COVID-19 are respiratory symptoms, but some patients develop severe thrombotic complications. Studies have looked into the association between the disease severity in COVID-19 patients and polymorphisms in the genes encoding prothrombotic and cardiovascular risk factors. The presented rare case describes inflammatory and acute thrombotic complications with musculoskeletal involvement in a patient with combined coagulation genetic defects. A 37-year-old woman was hospitalized with a respiratory infection of coronavirus etiology complicated by pneumonia and pulmonary embolism and confirmed using computed tomography and elevated D-dimer. Sixteen days after discharge, she developed deep vein thrombosis after discontinuation of antiplatelet and anticoagulant therapy due to bleeding. Four months after infection, we found bilateral avascular necrosis of the femoral head. The patient had a miscarriage with considerable blood loss and was given genetic testing, which confirmed the presence of a combined defect with a risk of both thrombosis and bleeding—heterozygous for the Leiden G1691A mutation, homozygous for the 677C>T mutation (MTHFR), heterozygous for the Val34Leu (factor XIII) mutation, and 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor 1 (PAI-1) genes. The described rare clinical case poses a serious challenge regarding the anticoagulant and antiplatelet therapy, especially in the presence of thrombotic complications in COVID-19 and the underlying genetic defect associated with a risk of bleeding, including life-threatening intracranial bleeding. More research is needed to better understand the major medical concern about antithrombotic treatment in COVID-19 patients with bleeding risk in the context of genetic coagulation disorders. The case raises the vigilance of clinicians to search for a genetic predisposition to the development of severe thrombotic events in COVID-19 patients with no other known underlying diseases.
Association between Serum 8-Iso-Prostaglandin F2α as an Oxidative Stress Marker and Immunological Markers in a Cohort of Preeclampsia Patients
Authors: Boldeanu Lidia , Văduva Constantin-Cristian , Caragea Daniel Cosmin , Novac Marius Bogdan , Manasia Mariana , Siloși Isabela , Manolea Maria Magdalena , Boldeanu Mihail Virgil , Dijmărescu Anda Lorena
Published: November 2023

Background: We aimed to analyze the presence and clinical use of serum 8-iso-prostaglandin F2-alpha (8-iso-PGF2α) as an oxidative stress marker and some inflammatory status biomarkers (tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), IL-10, high-sensitivity C-reactive protein (hs-CRP), and pentraxin-3 (PTX3)) for patients with preeclampsia (PE). Methods: Sixty pregnant women, including thirty diagnosed with PE and thirty who were healthy (NP), were included in this study. For the assessment of serum levels of biomarkers, we used the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Results: Our preliminary study showed that the expression level of serum 8-iso-PGF2α in the PE group was higher than in the PE after delivery (PE-AD) group (742.00 vs. 324.00 pg/mL, p < 0.0001). Groups of preeclamptic patients (PE + PE-AD) expressed significantly elevated levels for all of the assessed inflammatory mediators as compared to NP. Significant strong positive correlations with 8-iso-PGF2α levels were found for systolic blood pressure (SBP), and TNF-α (Spearman’s rho = 0.622, p-value = 0.020 and rho = 0.645, p-value = 0.002, respectively). Our study demonstrates that 8-iso-PGF2α and PTX3 have the greatest diagnostic value for pregnant women with PE. Conclusions: 8-iso-PGF2α and PTX3 can be used as independent predictor factors, along with already-known cytokines, that could represent a prophylactic way to help clinicians identify or predict which pregnant women will develop PE.
Omega-3-Enriched Diet Improves Metabolic Profile in Prdx6-Deficient Mice Exposed to Microgravity
Authors: Pacifici Francesca , Andreadi Aikaterini , Arriga Roberto , Pastore Donatella , Capuani Barbara , Bonanni Roberto , Della-Morte David , Bellia Alfonso , Lauro Davide , Donadel Giulia
Published: November 2023

Background: Space travel has always been one of mankind’s greatest dreams. Thanks to technological innovation, this dream is becoming more of a reality. Soon, humans (not only astronauts) will travel, live, and work in space. However, a microgravity environment can induce several pathological alterations that should be, at least in part, controlled and alleviated. Among those, glucose homeostasis impairment and insulin resistance occur, which can lead to reduced muscle mass and liver dysfunctions. Thus, it is relevant to shed light on the mechanism underlaying these pathological conditions, also considering a nutritional approach that can mitigate these effects. Methods: To achieve this goal, we used Prdx6−/− mice exposed to Hindlimb Unloading (HU), a well-established experimental protocol to simulate microgravity, fed with a chow diet or an omega-3-enriched diet. Results: Our results innovatively demonstrated that HU-induced metabolic alterations, mainly related to glucose metabolism, may be mitigated by the administration of omega-3-enriched diet. Specifically, a significant improvement in insulin resistance has been reported. Conclusions: Although preliminary, our results highlight the importance of specific nutritional approaches that can alleviate microgravity-induced harmful effects. These findings should be considered soon by those planning trips around the earth.
Strain and Strain Recovery of Human Hair from the Nano- to the Macroscale
Authors: Waldmann Brigitte , Hassler Martin F. T. , Müllner Alexander R. M. , Puchegger Stephan , Peterlik Herwig
Published: November 2023

In this study, in operandi SAXS experiments were conducted on samples of human hair with a varying degree of strain (2% within the elastic region and 10% beyond). Four different features in the SAXS patterns were evaluated: The intermediate filament distance perpendicular to and the distance from the meridional arc in the load direction, as well as the distances of the lipid bilayer peak in and perpendicular to the load direction. From the literature, one concludes that polar lipids in the cuticle are the origin of the lipid peak in the SAXS pattern, and this study shows that the observed strain in the lipids is much lower than in the intermediate filaments. We support these findings with SEM micrographs, which show that the scales in the cuticle deform much less than the cortex. The observed deformation of the intermediate filaments is very high, about 70% of the macrostrain, and the ratio of the transverse strain to the longitudinal strain at the nanoscale gives a Poisson ratio of νnano = 0.44, which is typical for soft matter. This work also finds that by varying the time period between two strain cycles, the typical strain recovery time is about 1000 min, i.e., one day. After this period, the structure is nearly identical to the initial structure, which suggests an interpretation that this is the typical time for the self-healing of hair after mechanical treatment.
A Multi-Stage Approach for External Trucks and Yard Cranes Scheduling with CO2 Emissions Considerations in Container Terminals
Authors: Talaat Ahmed , Gheith Mohamed , Eltawil Amr
Published: November 2023

Background: In container terminals, optimizing the scheduling of external trucks and yard cranes is crucial as it directly impacts the truck turnaround time, which is one of the most critical performance measures. Furthermore, proper scheduling of external trucks contributes to reducing CO2 emissions. Methods: This paper proposes a new approach based on a mixed integer programming model to schedule external trucks and yard cranes with the objective of minimizing CO2 emissions and reducing truck turnaround time, the gap between trucking companies’ preferred arrival time and appointed time, and the energy consumption of yard cranes. The proposed approach combines data analysis and operations research techniques. Specifically, it employs a K-means clustering algorithm to reduce the number of necessary truck trips for container handling. Additionally, a two-stage mathematical model is applied. The first stage employs a bi-objective mathematical model to plan the arrival of external trucks at the terminal gates. The second stage involves a mathematical model that schedules yard cranes’ movements between different yard blocks. Results: The results show that implementing this methodology in a hypothetical case study may lead to a substantial daily reduction of approximately 31% in CO2 emissions. Additionally, the results provide valuable insights into the trade-off between satisfying the trucking companies’ preferred arrival time and the total turnaround time. Conclusions: The integration of data clustering with mathematical modeling demonstrates a notable reduction in emissions, underscoring the viability of this strategy in promoting sustainability in port-related activities.
Machine Learning for Film Thickness Prediction in Elastohydrodynamic Lubricated Elliptical Contacts
Authors: Issa Joe , El Hajj Alain , Vergne Philippe , Habchi Wassim
Published: November 2023

This study extends the use of Machine Learning (ML) approaches for lubricant film thickness predictions to the general case of elliptical elastohydrodynamic (EHD) contacts, by considering wide and narrow contacts over a wide range of ellipticity and operating conditions. Finite element (FEM) simulations are used to generate substantial training and testing datasets that are used within the proposed ML framework. The complete dataset entails 915 samples; split into an 823-sample training dataset and a 92-sample testing dataset, corresponding to 90% and 10% of the combined dataset samples, respectively. The proposed ML model consists of a pre-processing stage in which conventional EHD dimensionless groups are used to minimize the number of inputs into the model, reducing them to only three. The core of the model is based on Gaussian Process Regression (GPR), a powerful ML regression tool, well-suited for small-sized datasets, producing output central and minimum film thicknesses, also in dimensionless form. The last stage is a post-processing one, in which the output film thicknesses are retrieved in dimensional from. The results reveal the capabilities and potential of the proposed ML framework, producing quasi-instantaneous predictions that are far more accurate than conventional film thickness analytical formulae. In fact, the produced central and minimum film thickness predictions are on average within 0.3% and 1.0% of the FEM results, respectively.
Microwave-Assisted Chemical Purification and Ultrasonication for Extraction of Nano-Fibrillated Cellulose from Potato Peel Waste
Authors: Sadeghi-Shapourabadi Mohsen , Elkoun Said , Robert Mathieu
Published: November 2023

Nanofibrillated cellulose was extracted from potato peel waste using a fast and green method with a simple process. To extract cellulose and eliminate non-cellulosic constituents, alkaline and hydrogen peroxide treatments were performed under microwave irradiation. The nanofibrillated cellulose was extracted from purified cellulose via TEMPO oxidation followed by ultrasonication. The TEM, FTIR, XRD, and TGA experiments were used to evaluate the structural, crystalline, and thermal properties of cellulose fiber and nanofiber. The chemical and FTIR analysis of bleached fibers indicates that almost all non-cellulosic components of biomass have been eliminated. The diameter of the extracted nanofibers is in the range of 4 to 22 nm. In terms of crystallinity, extracted nanocellulose had 70% crystallinity, compared to 17% for unprocessed lignocellulose fibers, which makes it an excellent choice for use as a reinforcement phase in biobased composites. Thermogravimetric analysis reveals that cellulose nanofibers are less thermally stable than potato peel pure cellulose, but it has a higher char content (28%) than pure cellulose (6%), which signifies that the carboxylate functionality acts as a flame retardant. The comparison between cellulose derived from microwave and conventional extraction methods confirmed that their impact on the removal of non-cellulosic materials is nearly identical.
Analytical Solutions of Partial Differential Equations Modeling the Mechanical Behavior of Non-Prismatic Slender Continua
Authors: Migliaccio Giovanni
Published: November 2023

Non-prismatic slender continua are the prototypical models of many structural elements used in engineering applications, such as wind turbine blades and towers. Unfortunately, closed-form expressions for stresses and strains in such continua are much more difficult to find than in prismatic ones, e.g., the de Saint-Venant’s cylinder, for which some analytical solutions are known. Starting from a suitable mechanical model of a tapered slender continuum with one dimension much larger than the other tapered two, a variational principle is exploited to derive the field equations, i.e., the set of partial differential equations and boundary conditions that govern its state of stress and strain. The obtained equations can be solved in closed form only in a few cases. Paradigmatic examples in which analytical solutions are obtainable in terms of stresses, strains, or related mechanical quantities of interest in engineering applications are presented and discussed.
Global Regular Axially Symmetric Solutions to the Navier–Stokes Equations: Part 1
Authors: Zaja̧czkowski Wojciech M.
Published: November 2023

The axially symmetric solutions to the Navier–Stokes equations are considered in a bounded cylinder Ω⊂R3 with the axis of symmetry. S1 is the boundary of the cylinder parallel to the axis of symmetry and S2 is perpendicular to it. We have two parts of S2. For simplicity, we assume the periodic boundary conditions on S2. On S1, we impose the vanishing of the normal component of velocity, the angular component of velocity, and the angular component of vorticity. We prove the existence of global regular solutions. To prove this, it is necessary that the coordinate of velocity along the axis of symmetry vanishes on it. We have to emphasize that the technique of weighted spaces applied to the stream function plays a crucial role in the proof of global regular axially symmetric solutions. The weighted spaces used are such that the stream function divided by the radius must vanish on the axis of symmetry. Currently, we do not know how to relax this restriction. In part 2 of this topic, the periodic boundary conditions on S2 are replaced by the conditions that both the normal component of velocity and the angular component of vorticity must vanish. Moreover, it is assumed that the normal derivative of the angular component of velocity also vanishes on S2. A transformation from part 1 to part 2 is not trivial because it needs new boundary value problems, so new estimates must be derived.
Metaheuristic Procedures for the Determination of a Bank of Switching Observers toward Soft Sensor Design with Application to an Alcoholic Fermentation Process
Authors: Kouvakas Nikolaos D. , Koumboulis Fotis N. , Fragkoulis Dimitrios G. , Fragulis George F.
Published: November 2023

The present work focused on the development of soft sensors for single-input single-output (SISO) nonlinear dynamic systems with unknown physical parameters using a switching observer design. Toward the development of more accurate soft sensors, as compared with hard sensors, an extended design methodology for the determination of a bank of operating points satisfying the dense web principle was proposed, where for the determination of the bank of operating points and the observer parameters, a metaheuristic procedure was developed. To validate the results of the metaheuristic algorithm, the case of an alcoholic fermentation process was studied as a special case of the present approach. For the nonlinear model of the process, an observer-based soft sensor was developed using the metaheuristic procedure. First, the accuracy of the linear approximant of the process with respect to the original nonlinear model was investigated. Second, the I/O reconstructability of the linear approximant was verified. Third, based on the linear approximant, an observer was designed for the estimation of the non-measurable variable. Fourth, considering that the observer is designed upon the linear approximant, the linear approximant model parameters are derived through identification, for different operating points, upon the nonlinear model. Fifth, the observers corresponding to the different operating points, constitute a bank of observers. The design was completed using a data-driven rule-based system, performing stepwise switching between the observers of the bank. The efficiency of the proposed metaheuristic algorithm and the performance of the switching scheme were demonstrated through a series of computational experiments, where it was observed that the herein-proposed approach was more than two orders of magnitude more accurate than traditional single-step approaches of transition from one operating point to another.
Network Pharmacology Integrated Molecular Docking and Dynamics to Elucidate Saffron Compounds Targeting Human COX-2 Protein
Authors: Ali Aarif , Wani Amir Bashir , Malla Bashir Ahmad , Poyya Jagadeesha , Dar Nawab John , Ali Fasil , Ahmad Sheikh Bilal , Rehman Muneeb U. , Nadeem Ahmed
Published: November 2023

Background and Objectives: Cyclooxygenase-2 (COX-2) is mostly linked to inflammation and has been validated as a molecular target for treating inflammatory diseases. The present study aimed to identify novel compounds that could inhibit COX-2, which is associated with various diseases including inflammation, and in such a scenario, plant-derived biomolecules have been considered as attractive candidates. Materials and Methods: In the present study, physiochemical properties and toxicity of natural compounds/drugs were determined by SWISSADME and ProTox-II. In the present study, the molecular docking binding features of saffron derivatives (crocetin, picrocrocin, quercetin, safranal, crocin, rutin, and dimethylcrocetin) against human COX-2 protein were assessed. Moreover, protein-protein interactions, topographic properties, gene enrichment analysis and molecular dynamics simulation were also determined. Results: The present study revealed that picrocrocin showed the highest binding affinity of −8.1 kcal/mol when docked against the COX-2 protein. PROCHECK analysis revealed that 90.3% of the protein residues were found in the most favored region. Compartmentalized Protein–Protein Interaction identified 90 interactions with an average interaction score of 0.62, and the highest localization score of 0.99 found in secretory pathways. The Computed Atlas of Surface Topography of Proteins was used to identify binding pockets and important residues that could serve as drug targets. Use of WEBnmα revealed protein dynamics by using normal mode analysis. Ligand and Receptor Dynamics used the Molecular Generalized Born Surface Area approach to determine the binding free energy of the protein. Gene enrichment analysis revealed that ovarian steroidogenesis, was the most significant enrichment pathway. Molecular dynamic simulations were executed for the best docked (COX-2-picrocrocin) complex, and the results displayed conformational alterations with more pronounced surface residue fluctuations in COX-2 with loss of the intra-protein hydrogen bonding network. The direct interaction of picrocrocin with various crucial amino-acid residues like GLN203, TYR385, HIS386 and 388, ASN382, and TRP387 causes modifications in these residues, which ultimately attenuates the activity of COX-2 protein. Conclusions: The present study revealed that picrocrocin was the most effective biomolecule and could be repurposed via computational approaches. However, various in vivo and in vitro observations are still needed.
Analysis of the Frequency of Mutations at Diagnostic Oligonucleotide Sites and Their Impact on the Efficiency of PCR for HIV-1
Authors: Bogoslovskaya Elena V. , Tsyganova Galina M. , Nosova Anastasiia O. , Shipulin German A.
Published: November 2023

The development of effective diagnostic kits for HIV-1 remains a pressing concern. We designed diagnostic oligonucleotides for HIV-1 real-time PCR to target the most conserved region of the HIV-1 genome and assessed the mutation frequency at annealing sites. Two databases of nucleotide sequences, Los Alamos and NCBI, were analyzed, revealing that more than 99% of the sequences either lack mutations or contain 1–2 mutations at the binding site of the forward and reverse primers. Additionally, 98.5% of the sequences either lack mutations or contain 1–2 mutations at the binding site of the TaqMan probe. To evaluate the efficiency of primers and the probe in real-time PCR in the case of mutations at their binding sites, we constructed several plasmids containing the most common mutations and, in a model experiment, showed how different mutations affect the efficiency of PCR. Our analysis demonstrated that about 98.5% of HIV-1 strains can be efficiently detected using a single pair of selected primers. For the remaining 1.5% of strains, a more careful selection of the second target is needed.
Conversion of Aluminosilicate Residue Generated from Lithium Extraction Process to NaX Zeolite
Authors: Ibsaine Fatima , Azizi Dariush , Dionne Justine , Tran Lan Huong , Coudert Lucie , Pasquier Louis-César , Blais Jean-François
Published: November 2023

The production of lithium from spodumene ores generates huge amounts of residues mainly composed of aluminosilicates. The main objective of the present study was to synthesize NaX zeolites with good ion-exchange capacity from these aluminosilicate residues, without using the fusion step or chemically modifying their initial Si/Al ratio. A physico-chemical (chemical composition, sorption capacity) and mineralogical (XRD, SEM) characterization of the zeolite synthesized using the conventional hydrothermal process (Process_1) was performed and compared with zeolite produced using a fusion step followed by a hydrothermal treatment process (Process_2) and commercial zeolite 13X. Then, the effect of operating parameters such as aging time and temperature, crystallization time and solid/liquid ratio on the sorption capacities of the synthesized zeolites using the conventional hydrothermal process was assessed. Initial aluminosilicate residues were mainly composed of Al2O3 (24.6%) and SiO2 (74.0%), while containing low amounts of potential contaminants (<1.6%). Based on its chemical composition, the fine fraction (<53 µm) was identified as the most suitable fraction to produce zeolites, while coarser fractions which contained higher Li content can be used to produce glass and ceramics. Physico-chemical and mineralogical characterization results show that zeolite produced using the conventional hydrothermal process (Process_1) had similar properties compared to zeolites 13X. Therefore, Process_1 was identified as the most performant while reducing operating costs related to alkaline fusion pre-treatments, which did not significantly improve zeolite properties. Finally, the optimum conditions for converting the residues into zeolite NaX, which had an ion-exchange capacity of 58 mg Ca/g were 8 h of aging at 75 °C and 16 h of crystallization at 100 °C, with a solid/liquid ratio of 1/10 (w/v).
Early Permian Post-Collision Extensional Setting in the Southern Beishan Orogenic Belt: Evidence from the Zhangfangshan Granodiorite and the Baishantang Bimodal Volcanic Rocks
Authors: Wu Lei , Zhai Xinwei , Wang Erteng , Chen Wanfeng , Song Gaorui , Zheng Feifei , Zhao Jiaolong , Wang Jinrong , Wang Haidong
Published: November 2023

Outcrops of late Paleozoic magmatic rocks are common in the Southern Beishan Orogenic Belt (SBOB), Southern Central Asian Orogenic Belt (CAOB), which is a key object for the understanding of regional tectonism and defining the final closure time of the Paleo-Asian Ocean (PAO). We present zircon U-Pb chronology and whole-rock geochemistry data for late Paleozoic granodiorites and bimodal volcanic rocks from the Shuangyingshan-Huaniushan unit in the north Huitongshan-Zhangfangshan ophiolitic belt in the SBOB. The Zhangfangshan granodiorites (LA-ICP-MS, Ca. 288 Ma) are A2-type granite enriched in Rb, Th, Pb and LREEs and depleted in Nb, Ta, Ti, Sr, Ba and HREEs. They have varying MgO and TFe2O3 contents with high Mg# (38.56~48.97) values; the Lu/Yb ratios (0.14~0.15) of these granodiorites are similar to mantle-derived magma. A clear plagioclase zoning structure and acicular apatite occur in mineral assemblages derived from magma mixing between mafic and felsic magmas. The Baishantang bimodal volcanic rocks (272 Ma) consist of rhyolite and basaltic andesite. Baishantang rhyolites are A2-type felsic rock enriched in Rb, Th, Pb and LREEs and depleted in Nb, Ta, Ti, Sr, Ba and HREEs, with negative εNd(t) and εHf(t) (−5.2~−4.8 and −2.2~−1.9, respectively). Rhyolites originated from the partial melting of the crust, influenced by mantle material. Basaltic andesites belong to calc-alkaline series and have an enrichment of Rb, Ba, Th, U, Pb and LREEs, are weakly enriched in Zr-Hf, and are depleted in Nb, Ta, Ti and HREEs. The Nd-Hf isotopes of these basaltic andesites are not coupled with negative εNd(t) (−2.8~−0.4) and positive εHf(t) (1.8~5.5) values. These characteristics indicate that they originated from the partial melting of the mantle mixed with sediment-derived melts. In combination with previous studies, our findings show that the early Permian Zhangfangshan granodiorites and Baishantang bimodal volcanic rocks formed in a post-collision extensional setting, and the Huitongshan-Zhangfangshan ocean had been closed before early Permian.
A Comprehensive Numerical Modeling Study for Parameter Optimization and Slope Stability Analysis in the Baganuur Lignite Coal Mine
Authors: Enkhbold Bilguun , Ikeda Hajime , Toriya Hisatoshi , Adachi Tsuyoshi
Published: November 2023

The “Baganuur” lignite coal mine is one of the biggest open cast mines in Mongolia. However, there is a huge challenge in managing the stability of its internal dump, which prevents the proper operation of the mine and has an impact on the economy. To solve the internal dump slope stability problem, this study focused on incorporating the inherent mechanical properties of the rock material to build numerical models of the internal dump. By applying two software programs from Rocscience (Phase2 and Slide) and four different methods, the finite element method, the Bishop method, the Janbu simplified method, and the Spencer simplified method, the current and improved internal dump parameters were numerically simulated and analyzed. Based on the properties of the rock, the LEM and FEM were used to determine the parameters that could have an impact on the stability of the internal waste dump. The impacts of the internal dump height, dip angle, and safety berm on these parameters were studied. This study covers several analytical methods for calculating safety factors. Based on the results of the numerical simulation, it is determined that it is possible to increase the internal dump capacity by approximately 56% at a 50 m height and 28° dip angle and using a 15 m safety berm. Under similar conditions, this study presents an optimum SRF at 40 m height, 28° dip angle, and 5 m safety berm. Based on the numerical models, it is found that changes in the dip angle have a greater impact than changes in the dump height on the slope stability of an internal dump.