bluuebunny/crossref_metadata_2025 huggingface dataset:
The Knowledge and Utilization of Traditional Birth Attendants by Women in a Rural Community of Ilorin, Northern Nigeria
Authors: Abdulwahab Lawal , Wuraola Salawu , Oluwanifemi Makanjuola , Ambali Ambali , Oreoluwa Alabi , Ahmed Kareem , Nwakama Chijindu , Maryam Akande , Tanimola Akande , Sumayya Al-Mansur , Yusuf Tijani , Mahmud Ahmed , Taofeek Aleem-Ghandi , John Adeyeye , Oni Nwafor , Peace Obateru , Lukman Lawal
Published: September 2023

Background: One of the major factors contributing towards high maternal morbidity and mortality in many developing countries is the lack of access to skilled maternal healthcare services, as traditional birth attendants (TBAs) continue to serve as predominant providers of maternal healthcare in many rural communities.

Aim: This study explores the knowledge and utilization of TBAs by women in a rural community, in order to identify healthcare gaps towards the provision of needed intervention.

Study Design: This study is a descriptive cross-sectional study which was conducted in Alanamu community of Ilorin, northern Nigeria, in the year 2019.

Methodology: A well-structured interviewer based questionnaire was administered to 212 women of reproductive age-group to collect data on their knowledge and utilization of the services of TBAs. Analysis was done using Statistical Product and Service Solutions (SPSS) software version 20.

Results: One hundred and fifty three respondents (72.2%) had background knowledge of TBAs, 91 (40.8%) had visited a TBA at least once to carry out their deliveries, of which 73 (80.2%) of them had successful deliveries, 18 (19.8%) had complications during their deliveries, of which 7 (7.7%) were referred to health care facilities for expect management.

The study showed statistical significance between the level of education of respondents and their patronage of TBAs with a P-value of .04.

Conclusion: Our study showed adequate knowledge and utilization of the services of TBAs by members of the community. The use of TBAs has continued to thrive in this rural community especially among the uneducated population and has been associated with maternal complications. The integration of TBAs with standard healthcare system as well as continuous sensitization of the public on their roles and limitations would go a long way in reducing maternal morbidity and mortality associated with the use of untrained TBAs.
Template Full Paper of ACESA
Authors: ACESA ACESA
Published: September 2023

Abstract should not exceed 150 words. The abstract should indicate the subject and scope of the paper and summarize the author’s overall research (Times New Roman 12).
Development of the Q4-CNS for Reissner-Mindlin Plate Bending
Authors: Soetanto Richo Michael
Published: September 2023

The paper was published on Matec WEB Conference Vol 147 - 2018, as seen link below: https://www.matec-conferences.org/articles/matecconf/abs/2018/06/matecconf_sibe2018_01002/matecconf_sibe2018_01002.html
Indoor Environmental Quality Effect Analysis in Green and Non-Green Office Buildings to Staff’s Performance and Satisfaction in Surabaya
Authors: Wijaya Elvina Shanggrama
Published: September 2023

Energy efficiency in an office building can decrease the company’s operational cost. Even so, the operational cost for staff is still larger than the cost for energy. Thus, it is important to reassure that the impact given by the building’s indoor environmental quality (IEQ) is positive to staff. This research focusses on two office buildings in Surabaya, one of them is designed using the green principles and calculations, and the other is not. The building’s IEQ aspects being inspected includes indoor air quality, thermal, lighting, acoustics and layout. A questionnaire survey was held to obtain the reaction from the full time staff regarding the building’s IEQ performance, their satisfaction to it and their self-assessed performance. There are IEQ aspects that affects staff’s performance and satisfaction significantly. The IEQ mean score differs significantly in green and non-green buildings, but the mean difference in satisfaction and performance were found not significant.
Lateral Soil Movement Due to Installation of a Single Pile using Jack-in Method
Authors: Wijaya Dewi Hindra
Published: September 2023

Lateral movement of soil due to the installation of a single pile using jack-in method was studied. The piles considered in this study were 15 piles of the diameter 800 mm. The lateral soil movement was predicted using Plaxis 2D, which incorporated cavity expansion theory as prescribed displacement. The results were compared to the recorded data from the field and those determined using several formulas. The comparison shows that the lateral movement of soil due to the installation of a single pile can be closely estimated using Plaxis 2D that employed a linear prescribed displacement of 0.42r at the pile head and zero at the pile tip. Lateral displacement of soil predicted using Plaxis 2D agrees well with data measured from the field both at the ground surface and along the depth of piles.
Highest and Best Use Analysis for an Apartment with Office Buildings or Shopping Centers in East Surabaya
Authors: Juwono Barca Hadi , Kwanda Timoticin , Anastasia Njo
Published: September 2023

Surabaya is the capital of East Java and the center of communityactivities. A developer has a plan to build a residential area in East Surabaya,located on Dharma Husada Indah Barat III road with an area of 7.123 m2. Afterconsidering many aspects, there are two alternative ideas that really attract theattention of this developer, namely, apartments with office buildings or apartmentswith shopping centers. The best decision results of the two alternatives can beanalyzed through the highest and best use (HBU) analysis method. The HBU mustfulfill four criteria, that is, legally permissible, physically possible, financiallyfeasible, and maximally productive. Of the two scenarios, the one that meets theHBU aspect is an apartment with office buildings, with the annual internal rate ofreturn of 99%, the net present value of Rp. 563.448.604.512,- with payback period60,46 months and discounted payback period 60,8 months.
KAJIAN PENDEKATAN TACTILE REGIONALISME DALAM ARSITEKTUR OSING
Authors: Dharmatanna Stephanus Wirawan , Hidayatun Maria Imaculata
Published: September 2023

Regionalisme dalam arsitektur merupakan cara menampilkan kembali gaya arsitektur kedaerahan ke dalam bangunan masa kini. Suku Osing adalah penduduk asli Banyuwangi atau juga di sebut sebagai Laros (akronim dari pada Lare Osing) atau Wong Blambangan merupakan penduduk mayoritas di beberapa kecamatan di Kabupaten Banyuwangi. Saat ini di Kabupaten Banyuwangi banyak bangunan yang didesain dengan menampilkan kembali ciri kedaerahannya beberapa di antaranya Aula Politeknik Banuwangi, Bandara Blimbingsari dan Hotel Sahid Osing yang dapat terlihat pada penggunaan elemen arsitektur masa lampau (AML) yaitu arsitektur osing. Metode penelitian yang digunakan pada penelitian ini adalah deskriptif kualitatif yaitu dengan melihat secara langsung Aula Politeknik Banuwangi, Bandara Blimbing Sari dan Hotel Sahid Osing. Tujuan penelitain ini adalah mengetahui elemen arsitektur yang mempengaruhi Aula Politeknik Banyuwangi, Bandara Blimbingsari dan Hotel Sahid Osing sebagai regionalisme arsitektur. Hasil dari penelitian ini adalah tactile sangat dapat di rasakan pada semua elemen terutama pada elemen atap dan langit - langit yang merupakan reinterpretasi, modifikasi dan inovai dari arsitektur rumah Osing.
CORRIDOR AS A SUSTAINABLE SOCIAL SPACE IN HIGH-RISE RESIDENTIAL BUILDING
Authors: Sagala Yuli Kalson , Damayanti Rully , Sunaryo Rony Gunawan
Published: September 2023

The rapid population growth and limited land on earth make high-rise residential buildings, especially in urban areas, inevitable. However, from several studies and analyses, many of these vertical living did not / have not fulfilled social sustainability aspects, which are essential aspects of the three spheres of sustainability concepts, namely social sustainability, economic sustainability, and environmental sustainability. Therefore this study will emphasize creating sustainable social space in high-rise residential buildings but will focus more on Corridor.Corridor as a definite area and always exist in high-rise residential building, have a high frequency always to be used and passed by residents as the main circulation path from and to the unit of residence. Therefore Corridor has great potential to influence the lives and way of life of the residents. Therefore, if we as architects can propose a design intervention by including consideration of the rules of the social space parameters, the Corridor can be an ideal sustainable social space that is needed and can be positively beneficial for residents, so that in the long run, it can help achieve Sustainable Architecture.
KAJIAN ASPEK TERRITORIAL REINFORCEMENT DALAM CPTED PADA RUMAH SUSUN SEDERHANA SEWA SOMBO SURABAYA
Authors: Jehu Ariel , Damayanti Rully
Published: September 2023

Pertumbuhan jumlah penduduk pada Kota Surabaya yang tidak diimbangi dengan ketersediaan lahan merupakan permasalahan yang dihadapi oleh pemerintah Indonesia setiap tahun. Dari beberapa upaya yang telah dilakukan, upaya pendekatan Rumah Susun Sederhana Sewa atau Rusunawa bagi penduduk berpenghasilan rendah merupakan salah satu solusi efektif. Namun, pada kenyataannya rusunawa yang sudah dibangun belum memberikan tempat tinggal yang nyaman dan aman. Pedoman Teknis Pembangunan Rumah Susun Sederhana Bertingkat Tinggi tahun 2007 belum secara fokus membahas pencegahan tindak kriminal melalui perancangan bangunan. Penelitian ini disusun untuk memberikan rekomendasi desain ruang semi-publik yang berpotensi terjadi tindak kriminal karena merupakan wadah bertemunya penghuni dalam dan luar. Penelitian ini mengevaluasi ruang semi-publik Rusunawa Sombo Surabaya menggunakan prinsip Crime Prevention Through Environmental Design dengan melakukan observasi langsung untuk mendapatkan data lapangan. Hasil analisa menunjukkan bahwa selain aspek perancangan bangunan, terdapat aspek sosial dan kebudayaan yang masih diterapkan oleh penghuni rusunawa yang dapat mendukung pencegahan tindak kriminal.
APLIKASI TEORITIS KONSEP HEALING ENVIRONMENT PADA LINGKUNGAN PERKANTORAN
Authors: Sambira Gelbriel Michelle Gracella Nartha , Damayanti Rully , Wardani Laksmi Kusuma
Published: September 2023

Usia dewasa merupakan usia yang rentan terkena stres karena besarnya kewajiban dan peran yang harus dipenuhi. Salah satu faktor yang mempengaruhi tingkat stres kaum dewasa muda adalah lingkungan kerja karena mereka lebih banyak menghabiskan waktu untuk bekerja. Menurut Okezone.com, 64% pekerja di Indonesia mengalami peningkatan stres kerja dibandingkan tahun sebelumnya. Salah satu faktor yang menyebabkan peningkatan stres tersebut adalah perusahaan yang lebih mementingkan faktor ekonomi dibandingkan kenyamanan karyawannya. Ketika karyawan kurang merasa nyaman dengan lingkungan kerjanya maka tingkat stres mereka akan bertambah dan dapat mengakibatkan dampak negatif pada kinerja karyawan dan pada perusahaan. Oleh karena itu diperlukan parameter desain lingkungan kerja perkantoran yang dapat menurunkan stres dan meningkatkan produktivitas karyawan. Konsep Healing Environment merupakan sebuah teori perancangan yang menghubungkan antara ruang dengan kesehatan dan well-being manusia agar menciptakan ruang yang membuat pengguna merasa lebih baik dan lebih bahagia. Untuk itu penelitian ini dilakukan untuk mengetahui parameter Healing Environment yang dapat diterapkan pada gedung perkantoran dengan menggunakan metode studi literatur yaitu metode yang dilakukan hanya dengan berdasarkan karya tertulis yang relevan dengan teori Healing Environment, data yang didapatkan dari hasil analisis kemudian saling dikaitkan dan dirangkum untuk menghasilkan parameter Healing Environment yang dapat diterapkan pada perkantoran. Hasil penelitian ini menunjukkan bahwa terdapat enam parameter Healing Environment yang dapat diterapkan pada perkantoran yaitu heirarki, daylight & lighting, natural air & penghawaan, view & nature, material & colors, dan can rest.
EVALUASI UNIT HUNIAN GRAHA APARNA SIWALANKERTO SURABAYA BERDASARKAN KRITERIA RUMAH SEHAT DI MASA NEW NORMAL
Authors: Larasati Christina Putri , Arifin Lilianny Sigit , Tulistyantoro Lintu
Published: September 2023

Lockdown atau stay at home akibat penyebaran Coronavirus 2019 telah sedikit banyak menyadarkan pentingnya kesehatan, kenyamanan space, serta fleksibilitas ruang untuk mewadahi kebutuhan penggunanya diera new normal dalam hunian termasuk hunian vertikal sederhana. Melalui penelitian di Graha Aparna Siwalankerto berupa evaluasi kualitas ruang berdasarkan kriteria rumah sehat di empat unit dari dua tower yang dipilih dengan tujuan melihat kesehatan ruang dalam unit unit tersebut untuk pengembangan hunian vertikal sederhana kedepannya nanti. Ada lima variabel utama yang diujikan yakni indoor air quality , indoor acoustic comfort, lighting, temperature comfort, dan indoor space quality. Dalam penelitian ini digunakan metode kualitatif deskriptif, dimana data di awal didapat dari survei di lapangan langsung kemudian dibandingkan dengan ketentuan standar dan dijabarkan secara deskriptif berdasarkan tiap poinnya. Dari penelitian ini didapatkan bahwa unit yang berada di lantai dasar masih perlu dilakukan pengembangan untuk mencapai unit hunian yang sehat dimasa new normal.
PARAMETER DESAIN UNIT HUNIAN RAMAH ANAK PADA APARTEMEN MENENGAH KEBAWAH (STUDI KASUS APARTEMEN CBD DI SURABAYA)
Authors: Wuwung Kevin Eduard , Damayanti Rully , Kwanda Timoticin
Published: September 2023

Perkembangan penduduk yang cukup pesat di kota Surabaya menyebabkan adanya tren perpindahan dari landed house ke vertical housing. Tapi sayangnya sering kali apartemen menengah kebawah tidak mempertimbangkan anak – anak dan hanya bertujuan untuk memenuhi kebutuhan pasar padahal anak – anak memiliki pemahaman ruang dan kebutuhan ruang yang berbeda denga orang dewasa. Penelitian ini menggunakan metode pendekatan deskriptif kualitatif dengan jenis penelitian studi kasus. Setelah memperoleh data yang dibutuhkan dilakukan proses pengecheckan dengan variabel dan indikator ramah anak. Dari hasil data tersebut diperoleh parameter desain unit hunian ramah anak pada apartemen kelas menengah kebawah.
Analisis Artikulasi Tektonika Pada Fasilitas Penyembuhan bagi Anak Penyandang Disabilitas
Authors: Amadeo Leonard , Arifin Lilianny Sigit
Published: September 2023

Disabilitas adalah kondisi dimana seseorang memiliki keterbatasan, baik secara fisik, mental, intelektual, atau sensorik. Kondisi ini dapat dialami semua kelompok usia, termasuk anak-anak. Anak-anak dengan disabilitas mengalami kesulitan dan hambatan sehari-hari. Fasilitas healing sendiri berperan penting dalam meningkatkan kondisi psikologis anak dalam menjalani aktivitas sehari-hari. Perancangan fasilitas healing yang efektif memerlukan teknik tertentu hingga bangunan dapat memberikan dampak emosional bagi anak-anak tersebut. Pemahaman ini sesuai dengan tektonika menurut Eduard Sekler, yaitu struktur dan konstruksi yang membangkitkan emosi pengunjungnya. Penelitian membahas dua studi kasus yang dianalisis sesuai parameter tektonika Eduard Sekler. Penelitian dilakukan melalui kajian literatur dan data dianalisis secara kualitatif dan interpretatif. Hasil interpretasi menunjukkan adanya pengaruh yang diberikan oleh struktur dan konstruksi terhadap emosi yang muncul pada diri anak-anak di kedua bangunan. Meski begitu, struktur yang sama dapat menghasilkan emosi yang berbeda dengan metode konstruksi yang berbeda. Peneliti menyimpulkan bahwa metode konstruksi lebih berperan dalam membangkitkan emosi tertentu.Keywords: disabilitas, healing, konstruksi, struktur, tektonika
Tipologi Pembentuk Kota (Street Connectivity) dan Walkability Pada Kawasan Tunjungan Surabaya
Authors: Siswanto Angelique Hillary , Sunaryo Rony Gunawan
Published: September 2023

Kawasan Tunjungan merupakan kawasan penting di Surabaya sejak 1866 hingga sekarang. Berawal sebagai koridor penghubung antara Kota Lama dan Baru Surabaya, Tunjungan berkembang menjadi shopping-district yang terkenal dan menggerakkan roda ekonomi sekaligus sosial-budaya kota. Fenomena automobile-dependent lekat dengan masyarakat membuat orang berfokus hanya pada jalan raya, melupakan keberadaan jalan kecil yang melengkapi kawasan. Pemetaan jalan secara menyeluruh akan berdampak dalam pemerataan kawasan yang sekarang hanya terpusat di Jalan Tunjungan. Riset ini mempelajari konektivitas tipologi pembentuk kota (road mapping) dan kualitas walkability kawasan. Riset menganalisa morfologi kawasan secara sinkronis-diakronis, memetakan rute pejalan kaki-sepeda, mengidentifikasi ruang terbuka dan fasilitas publik serta menganalisa walkability kawasan melalui peta pedestrian-shed. Hasil riset dari pemetaan jalan membuka  konektivitas baru yang sebelumnya tidak terlihat ketika melintasi kawasan dengan kendaraan bermotor. Riset juga menemukan variasi dan intensitas ruas jalan yang tinggi, membuat pengkajian rute jalan berdasarkan peta ped-shed menunjukkan angka permeabilitas kawasan (walkability) yang baik yaitu 0,67 dari 1,00. Namun angka ini tidak didukung dengan persentase dedicated pedestrian pathway yang baik, baru 45% jalan di kawasan nyaman digunakan. Pengolahan pedestrian yang baik (revitalisasi trotoar) akan menunjang aktivitas di kawasan dengan berjalan kaki ataupun bersepeda yang dapat mengurangi automobile dependency.
Reproductive Factors and Endometrial Cancer Risk Among Women
Authors: Katagiri Ryoko , Iwasaki Motoki , Abe Sarah Krull , Islam Md. Rashedul , Rahman Md. Shafiur , Saito Eiko , Merritt Melissa A. , Choi Ji-Yeob , Shin Aesun , Sawada Norie , Tamakoshi Akiko , Koh Woon-Puay , Sakata Ritsu , Tsuji Ichiro , Kim Jeongseon , Nagata Chisato , Park Sue K. , Kweon Sun-Seog , Shu Xiao-Ou , Gao Yu-Tang , Tsugane Shoichiro , Kimura Takashi , Yuan Jian-Min , Kanemura Seiki , Lu Yukai , Sugawara Yumi , Wada Keiko , Shin Min-Ho , Ahsan Habibul , Boffetta Paolo , Chia Kee Seng , Matsuo Keitaro , Qiao You-Lin , Rothman Nathaniel , Zheng Wei , Inoue Manami , Kang Daehee
Published: September 2023

Importance

Despite evidence of an association between reproductive factors and endometrial cancer risk, prospective studies have been conducted mainly in non-Asian countries.

Objective

To assess the association between reproductive factors, such as number of deliveries, age at menarche, or menopause, and endometrial cancer risk.

Design, Setting, and Participants

This cohort study used pooled individual data from 13 prospective cohort studies conducted between 1963 and 2014 in the Asia Cohort Consortium. Participants were Asian women. Data analysis was conducted from September 2019 to April 2023.

Exposures

Reproductive factors were assessed using a questionnaire in each cohort.

Main Outcomes and Measures

The main outcome was time to incidence of endometrial cancer. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% CIs.

Results

A total of 1005 endometrial cancer cases were detected among 332 625 women (mean [SD] age, 54.3 [10.4] years) during a mean (SD) of 16.5 (6.4) years of follow-up. Increasing number of deliveries was associated with a decreased endometrial cancer risk in a dose-response manner (≥5 deliveries vs nulliparous [reference]: HR, 0.37; 95% CI, 0.26-0.53; P for trend < .001). Compared with menarche at younger than 13 years, menarche at 17 years or older had an HR of 0.64 (95% CI, 0.48-0.86; P for trend < .001). Late menopause (age ≥55 years) showed an HR of 2.84 (95% CI, 1.78-4.55; P for trend < .001) compared with the youngest age category for menopause (<45 years). Age at first delivery, hormone therapy, and breastfeeding were not associated with endometrial cancer risk.

Conclusions and Relevance

This large pooled study of individual participant data found that late menarche, early menopause, and a higher number of deliveries were significantly associated with a lower risk of endometrial cancer. These convincing results from Asian prospective studies add to the growing body of evidence for the association between reproductive factors and endometrial cancer.
Vaccines and the Risk of Hospitalization for Multiple Sclerosis Flare-Ups
Authors: Grimaldi Lamiae , Papeix Caroline , Hamon Yann , Buchard Albert , Moride Yola , Benichou Jacques , Duchemin Tom , Abenhaim Lucien
Published: September 2023

Importance

Scientific literature is sparse about the association of vaccination with the onset of multiple sclerosis (MS) flare-ups. Immunization by vaccines of the entire population is crucially important for public health.

Objective

To evaluate the risk of hospitalization for severe MS flare-ups after vaccination in patients with MS.

Design, Setting, Participants

This cohort study included patients diagnosed with MS between January 1, 2007, and December 31, 2017, who were included in the System of National Health Databases, a national health claims database in France. In a nested case-crossover analysis, cases were defined by vaccine exposure prior to the onset of hospitalization due to an MS flare-up, and flare-up rates were compared with those that occurred prior to vaccine exposure in up to 4 control time windows immediately preceding the at-risk time window (ie, the MS flare-up) for each patient. Data were analyzed from January 2022 to December 2022.

Exposure

Receipt of at least 1 vaccination, including the diphtheria, tetanus, poliomyelitis, pertussis, or Haemophilus influenzae (DTPPHi) vaccine, influenza vaccine, and pneumococcal vaccine, during follow-up.

Main Outcomes and Measures

The primary outcome was the risk of hospitalization for an MS flare-up after receipt of a vaccine. Adjusted odds ratios (AORs) and 95% CIs were derived using conditional logistic regression to measure the risk of hospitalization for an MS flare-up associated with vaccination.

Results

A total of 106 523 patients constituted the MS cohort (mean [SD] age, 43.9 [13.8] years; 76 471 females [71.8%]; 33 864 patients [31.8%] had incident MS and 72 659 patients [68.2%] had prevalent MS) and were followed up for a mean (SD) of 8.8 (3.1) years. Of these patients, 35 265 (33.1%) were hospitalized for MS flare-ups during the follow-up period for a total of 54 036 MS-related hospitalizations. The AORs of hospitalization for an MS flare-up and vaccine exposure in the 60 days prior to the flare-up were 1.00 (95% CI, 0.92-1.09) for all vaccines, 0.95 (95% CI, 0.82-1.11) for the DTPPHi, 0.98 (95% CI, 0.88-1.09) for the influenza vaccine, and 1.20 (95% CI, 0.94-1.55) for the pneumococcal vaccine.

Conclusions and Relevance

A nationwide study of the French population found no association between vaccination and the risk of hospitalization due to MS flare-ups. However, considering the number of vaccine subtypes available, further studies are needed to confirm these results.
Cost-Related Barriers and Ensuring Equitable Access to Vaccines in the US
Authors: Essien Utibe R. , Dusetzina Stacie B.
Published: September 2023

This Viewpoint discusses policies toward increasing access to effective COVID-19 vaccines, advancing vaccine equity, strengthening reimbursement policies, and increasing federal incentives for insurers and health systems to improve COVID-19 vaccine uptake.
A Self‐Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture
Authors: Zargarzadeh Mehrzad , Gomes Maria C. , Patrício Sónia G. , Custódio Catarina A. , Mano João F.
Published: September 2023

Photo‐crosslinkable platelet lysate (PL)‐based hydrogels have been proven to support human‐derived cell cultures owing to their high content of bioactive molecules, such as cytokines and growth factors. As a unique self‐maintained and biocompatible 3D scaffold, the recently reported self‐feeding hydrogels with enzyme‐empowered degradation capacity have shown high biological performance in vitro and in vivo. To take advantage of all features of both PL and self‐feeding hydrogels, here UV responsive laminaran‐methacrylate (LamMA) and PL‐methacrylate (PLMA) derivatives plus glucoamylase (GA), which significantly improve the overall features of a 3D system, is coupled. This self‐sustaining hybrid hydrogel emerges as a unique scaffold due to the sustained delivery of glucose produced via enzymatic degradation of laminaran while granting the release of growth factors through the presence of PL. This biomaterial is applied to fabricate high‐throughput freestanding microgels with controlled geometric shapes. Furthermore, this multicomponent hybrid hydrogel is successfully implemented as the first reported glucose supplier bioink to manufacture intricate and precisely defined cell‐laden structures using a support matrix. Finally, such hydrogels are utilized as a proof of concept to serve as 3D in vitro cancer models, with the aim of recapitulating the tumor microenvironment.
A Bioengineering‐Regenerative Medicine Approach for Ocular Surface Reconstruction Using a Functionalized Native Cornea‐Derived Bio‐Scaffold
Authors: Park Mijeong , Richardson Alex , Delic Naomi , Nguyen Kim , Biazik Joanna , Zhang Richard , Sprogyte Lina , Nureen Lamia , Lees Justin , Fajardo Angelica , Kunicki Ursula , Watson Stephanie L. , Males John , Girolamo Nick Di
Published: September 2023

Limbal stem cell deficiency (LSCD) is characterized by the loss of limbal epithelial stem cells (LESCs) which compromises corneal transparency, leading to blindness. It cannot be treated with pharmacological or corneal transplantation interventions, instead a specialized stem cell (SC) therapy is needed to restore eye health and sight. Herein, a native cornea‐derived biomaterial, a by‐product of a laser refractive surgical procedure called small incision lenticule extraction is identified as a new cell delivery matrix. Culture conditions are optimized to facilitate LESC attachment, expansion and stratification, and their identity is immunophenotyped. Using electron microscopy, bio‐constructs display stratification, similar to the architectural and cellular organization of a native mammalian cornea with formation of a basement membrane and an orderly array of collagen fibrils. Neuronal growth and depleted CD45+/CD14+ leukocytes on lenticules are also shown, suggesting that in transplantation experiments, they will re‐innervate and not trigger a host‐mediated immune response. Finally, human lenticules are geometrically customized to successfully fit them over a LSCD murine cornea ex vivo, during which they maintain curvature. The authors are poised to conduced similar studies in live mice using these and other carriers currently used in the clinic to compare SC therapy outcomes.
Photoinduced Contact Evolution and Junction Rearrangement in Two‐Dimensional van der Waals Heterostructure
Authors: Cen Yingqian , Tu Yudi , Zhu Jingting , Hu Yutao , Hao Qiaoyan , Zhang Wenjing
Published: September 2023

Devices based on 2DMs van der Waals (vdW) heterostructures always compose of multiple contacts. Due to the instability of nanoscale 2DMs and interfaces, these contacts can be affected by the operation‐induced photo or thermal effect. They can trigger the evolution of junctions and rearrange the junctions across a device, which are detrimental for applications. Herein, vdW heterostructure of indium selenide (InSe) and black phosphorus (BP) on Au electrodes are investigated to reveal the contact evolution and its relation to device performance. During operation, light irradiation changes the I–V characteristics from symmetry to strong rectification. Photocurrent mapping and Kelvin‐probe force microscopy (KPFM) reveal triple junctions in this heterostructure, i.e., Au‐InSe junction, InSe homojunction, and InSe‐BP heterojunction. The variation of I–V characteristics of vdW heterostructure is ascribed to the evolution of Au‐InSe junction from quasi‐ohmic junction with a near‐zero work function difference (Δφ) to a strong Schottky junction (Δφ = ≈0.27 eV). The stabilized device demonstrates distinguished time‐domain response at individual junctions and overall device, indicating the evolution of contacts and the consequent opposite junction directions degrade the overall device performance. This research emphasizes the importance of dealing with heterogeneous contacts and junction directions in designing vdW heterostructure photodetectors.
A Zwitterionic Hydrogel with Anti‐Oxidative and Anti‐Inflammatory Properties for the Prevention of Peritoneal Adhesion by Inhibiting Mesothelial‐Mesenchymal Transition
Authors: Yu Qingyu , Sun Hong , Zhang Linhua , Jiang Lijie , Liang Lei , Yu Chaojie , Dong Xiaoru , Guo Bingyan , Qiu Yuwei , Li Jingwu , Zhang Hong , Yao Fanglian , Zhu Dunwan , Li Junjie
Published: September 2023

Postoperative peritoneal adhesion is a serious clinical complication. Various hydrogel barriers have been developed to prevent peritoneal adhesion. However, it remains a challenge to design a hydrogel with desirable physicochemical properties and bioactivities. In this study, a zwitterionic polysaccharide‐based multifunctional hydrogel is developed using epigallocatechin‐3‐gallate (EGCG) to prevent postoperative abdominal adhesion. This hydrogel is simple to use and has desirable properties, such as excellent injectability, self‐healing, and non‐swelling properties. The hydrogel also has ultralow fouling capabilities, such as superior bactericidal performance, cell and protein adhesion, and low immunogenicity resistance. Moreover, the hydrogel exhibits good antioxidant activity, which is attributed to the integration of EGCG. Furthermore, the detailed mechanism from in vivo and in vitro experimental studies illustrates that hydrogel compositions can synergistically prevent adhesion formation through multiple pathways, including anti‐inflammatory and antioxidant capabilities and inhibition effects on the mesothelial‐mesenchymal transition (MMT) process induced by transforming growth factor (TGF‐β). In summary, this zwitterionic multifunctional hydrogel has great potential to prevent postoperative adhesion formation in the clinical setting.
Stabilizing Precursor Solution and Controlling Crystallization Kinetics Simultaneously for High‐Performance Perovskite Solar Cells
Authors: Wu Nan , Yang Tinghuan , Wang Zhichao , Wu Yin , Wang Yajie , Ma Chuang , Li Haojin , Du Yachao , Zhao Di , Wang Shuang , Liu Pengchi , Huang Wenliang , Ren Xiaodong , Liu Shengzhong (Frank) , Zhao Kui
Published: September 2023

The efficiency of metal halide perovskite solar cells (PSCs) has skyrocketed; however, defects created by aging precursor solutions and during crystallization pose a significant barrier to the reproducibility and efficiency of solar cells. In this work, fluoro‐N,N,N″,N″‐tetramethylformamidinium hexafluorophosphate (F‐(CH3)4CN2PF6, abbreviated as TFFH) is introduced to stabilize precursor solution and improve crystallization dynamics simultaneously for high‐performance formamidinium lead iodide (FAPbI3)‐based perovskite indoor photovoltaics. The TFFH stabilizes the precursor solution by inhibiting oxidation of I− and reducing newly generated I0 to I−, and passivates undercoordinated Pb2+ by interacting with the Pb─I framework. Time‐resolved optical diagnostics show prolonged perovskite crystallization dynamics and in situ defect passivation due to the presence of strong FA+···TFFH···Pb─I interaction. Simultaneous regulation of precursor solution and crystallization dynamics guarantee larger perovskite grain sizes, better crystal orientation, fewer defects and more efficient charge extraction in PSCs. The optimized PSCs achieve improved reproducibility and better stability and reach an efficiency of 42.43% at illumination of 1002 lux, which is the highest efficiency among all indoor photovoltaics. It is anticipated that the concurrent stabilization of solutions and regulation of crystallization dynamics will emerge as a prevalent approach for enhancing the reproducibility and efficiency of perovskite.
How Reproducible is the Synthesis of Zr–Porphyrin Metal–Organic Frameworks? An Interlaboratory Study
Authors: Boström Hanna L. B. , Emmerling Sebastian , Heck Fabian , Koschnick Charlotte , Jones Andrew J. , Cliffe Matthew J. , Al Natour Rawan , Bonneau Mickaële , Guillerm Vincent , Shekhah Osama , Eddaoudi Mohamed , Lopez‐Cabrelles Javier , Furukawa Shuhei , Romero‐Angel María , Martí‐Gastaldo Carlos , Yan Minliang , Morris Amanda J. , Romero‐Muñiz Ignacio , Xiong Ying , Platero‐Prats Ana E. , Roth Jocelyn , Queen Wendy L. , Mertin Kalle S. , Schier Danielle E. , Champness Neil R. , Yeung Hamish H.‐M. , Lotsch Bettina V.
Published: September 2023

Metal–organic frameworks (MOFs) are a rapidly growing class of materials that offer great promise in various applications. However, the synthesis remains challenging: for example, a range of crystal structures can often be accessed from the same building blocks, which complicates the phase selectivity. Likewise, the high sensitivity to slight changes in synthesis conditions may cause reproducibility issues. This is crucial, as it hampers the research and commercialization of affected MOFs. Here, it presents the first‐ever interlaboratory study of the synthetic reproducibility of two Zr–porphyrin MOFs, PCN‐222 and PCN‐224, to investigate the scope of this problem. For PCN‐222, only one sample out of ten was phase pure and of the correct symmetry, while for PCN‐224, three are phase pure, although none of these show the spatial linker order characteristic of PCN‐224. Instead, these samples resemble dPCN‐224 (disordered PCN‐224), which has recently been reported. The variability in thermal behavior, defect content, and surface area of the synthesised samples are also studied. The results have important ramifications for field of metal–organic frameworks and their crystallization, by highlighting the synthetic challenges associated with a multi‐variable synthesis space and flat energy landscapes characteristic of MOFs.
Water‐Resistant Subwavelength Perovskite Lasing from Transparent Silica‐Based Nanocavity
Authors: Huang Sihao , Shen Zixi , Liao Yang , Liu Zhengzheng , Hu Zhiping , Li Qian , Zhang Zeyu , Dong Siyu , Luo Jiajun , Du Juan , Tang Jiang , Leng Yuxin
Published: September 2023

Great research efforts are devoted to exploring the miniaturization of chip‐scale coherent light sources possessing excellent lasing performance. Despite the indispensable role in Si photonics, SiO2 is generally considered not contributing to the starting up and operation of integrated lasers. Here, this work demonstrates an extraordinary‐performance subwavelength‐scale perovskite vertical cavity laser with all‐transparent SiO2 cavity, whose cavity is ultra‐simple and composed of only two parallel SiO2 plates. By introducing a ligand‐assisted thermally co‐evaporation strategy, highly luminescent perovskite film with high reproducibility and excellent optical gain is grown directly on SiO2. Benefitting from their high‐refractive‐index contrast, low‐threshold, high‐quality factor, and single‐mode lasing is achieved in subwavelength range of ≈120 nm, and verified by long‐range coherence distance (115.6 µm) and high linear polarization degree (82%). More importantly, the subwavelength perovskite laser device could operate in water for 20 days without any observable degradation, exhibiting ultra‐stable water‐resistant performance. These findings would provide a simple but robust and reliable strategy for the miniaturized on‐chip lasers compatible with Si photonics.
A Data‐Driven Approach to Molten Salt Synthesis of N‐Rich Carbon Adsorbents for Selective CO2 Capture
Authors: Burrow James N. , Eichler John E. , Martinez Wuilian A. , Mullins C. Buddie
Published: September 2023

Applying a design of experiments methodology to the molten salt synthesis of nanoporous carbons enables inverse design and optimization of nitrogen (N)‐rich carbon adsorbents with excellent CO2/N2 selectivity and appreciable CO2 capacity for carbon capture via swing adsorption from dilute gas mixtures such as natural gas combined cycle flue gas. This data‐driven study reveals fundamental structure‐function relationships between the synthesis conditions, physicochemical properties, and achievable selective adsorption performance of N‐rich nanoporous carbons derived from molten salt synthesis for CO2 capture. Taking advantage of size‐sieving separation of CO2 (3.30 Å) from N2 (3.64 Å) within the turbostratic nanostructure of these N‐rich carbons, while limiting deleterious N2 adsorption in a weaker adsorption site that harms selectivity, enables a large CO2 capacity (0.73 mmol g−1 at 30.4 Torr and 30 °C) with noteworthy concurrent CO2/N2 selectivity as predicted by the ideal adsorbed solution theory (SIAST = 246) with an adsorbed phase purity of 91% from a simulated gas stream containing only 4% CO2. Optimized N‐rich porous carbons, with good physicochemical stability, low cost, and moderate regeneration energy, can achieve performance for selective CO2 adsorption that competes with other classes of advanced porous materials such as chemisorbing zeolites and functionalized metal‐organic frameworks.
NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post‐Myocardial Infarction via Human Antigen R
Authors: Guo Chenghu , Ji Wei , Yang Wei , Deng Qiming , Zheng Tengfei , Wang Zunzhe , Sui Wenhai , Zhai Chungang , Yu Fangpu , Xi Bo , Yu Xiao , Xu Feng , Zhang Qunye , Zhang Wencheng , Kong Jing , Zhang Meng , Zhang Cheng
Published: September 2023

Myocardial infarction (MI) remains the leading cause of death worldwide. Cardiac fibroblasts (CFs) are abundant in the heart and are responsible for cardiac repair post‐MI. NF‐κB‐repressing factor (NKRF) plays a significant role in the transcriptional inhibition of various specific genes. However, the NKRF action mechanism in CFs remains unclear in cardiac repair post‐MI. This study investigates the NKRF mechanism in cardiac remodeling and dysfunction post‐MI by establishing a CF‐specific NKRF‐knockout (NKRF‐CKO) mouse model. NKRF expression is downregulated in CFs in response to pathological cardiac remodeling in vivo and TNF‐α in vitro. NKRF‐CKO mice demonstrate worse cardiac function and survival and increased infarct size, heart weight, and MMP2 and MMP9 expression post‐MI compared with littermates. NKRF inhibits CF migration and invasion in vitro by downregulating MMP2 and MMP9 expression. Mechanistically, NKRF inhibits human antigen R (HuR) transcription by binding to the classical negative regulatory element within the HuR promoter via an NF‐κB‐dependent mechanism. This decreases HuR‐targeted Mmp2 and Mmp9 mRNA stability. This study suggests that NKRF is a therapeutic target for pathological cardiac remodeling.
Recent Progress on the Catalysts and Device Designs for (Photo)Electrochemical On‐Site H2O2 Production
Authors: Wang Qi , Ren Liping , Zhang Jie , Chen Xin , Chen Chunying , Zhang Fei , Wang Shuai , Chen Jie , Wei Jinjia
Published: September 2023

Low‐cost and on‐site H2O2 production is desirable for industrial and civilian usage. (Photo)electrochemical H2O2 production is proposed to be a safer, greener, and cheaper strategy for on‐site H2O2 production as compared to the conventional anthraquinone process and the direct thermal synthesis. However, the efficiency, selectivity, and durability of the (photo)electrochemical H2O2 production devices are still not satisfactory. Therefore, there is an urgent need to revisit the (photo)electrocatalyst and device designs for (photo)electrochemical on‐site H2O2 production, thus to rationalize the research thoughts and provide valuable guidance. This review comprehensively summarizes and discusses the mechanism of two‐electron oxygen reduction reaction (2e− ORR) and two‐electron water oxidation reaction (2e− WOR) for H2O2 production, and the current research status on the (photo)electrocatalysts and (photo)electrochemical devices. In particular, the pros and cons of the four types of (photo)electrochemical device designs, which are Type I (2e− ORR + oxygen evolution reaction), Type II (2e− ORR + hydrogen oxidation reaction), Type III (2e− WOR + hydrogen evolution reaction) and Type IV (2e− WOR + 2e− ORR), are discussed in detail. Finally, a practical perspective on the future research directions for the on‐site (photo)electrochemical H2O2 production based on the technical challenges of this technique is provided.
Magnetoresistance in Organic Spin Valves Based on Acid‐Exfoliated 2D Covalent Organic Frameworks Thin Films
Authors: Liu Xitong , Li Hao , Zhang Weifeng , Yang Zhen , Li Dong , Liu Mengya , Jin Kuijuan , Wang Liping , Yu Gui
Published: September 2023

Covalent organic frameworks (COFs), as a burgeoning class of crystalline porous materials, have made significant progress in their application to optoelectronic devices such as field‐effect transistors, memristors, and photodetectors. However, the insoluble features of microcrystalline two‐dimensional (2D) COF powders limit development of their thin film devices. Additionally, the exploration of spin transport properties in this category of π‐conjugated skeleton materials remains vacant thus far. Herein, an imine‐linked 2D Py‐Np COF nanocrystalline powder was synthesized by Schiff base condensation of 4,4′,4′′,4′′′‐(pyrene‐1,3,6,8‐tetrayl)tetraaniline and naphthalene‐2,6‐dicarbaldehyde. Then, we prepared a large‐scale free‐standing Py‐Np COF film via a top‐down strategy of chemically assisted acid exfoliation. Moreover, high‐quality COF films acted as active layers were transferred onto ferromagnetic La0.67Sr0.33MnO3(LSMO) electrodes for the first attempt to fabricate organic spin valves (OSVs) based on 2D COF materials. This COF‐based OSV device with a configuration of LSMO/Py‐Np COF/Co/Au demonstrated a remarkable magnetoresistance (MR) value up to −26.5 % at 30 K. Meanwhile, the MR behavior of the COF‐based OSVs exhibited a highly temperature dependence and operational stability. This work highlights the enormous application prospects of 2D COFs in organic spintronics and provides a promising approach for developing electronic and spintronic devices based on acid‐exfoliated COF thin films.
Customizing amino acid metabolism of Pichia pastoris for recombinant protein production
Authors: Rußmayer Hannes , Buchetics Markus , Mattanovich Matthias , Neubauer Stefan , Steiger Matthias , Graf Alexandra B. , Koellensperger Gunda , Hann Stephan , Sauer Michael , Gasser Brigitte , Mattanovich Diethard
Published: September 2023

Amino acids are the building blocks of proteins. In this respect, a reciprocal effect of recombinant protein production on amino acid biosynthesis as well as the impact of the availability of free amino acids on protein production can be anticipated. In this study, the impact of engineering the amino acid metabolism on the production of recombinant proteins was investigated in the yeast Pichia pastoris (syn Komagataella phaffii). Based on comprehensive systems‐level analyses of the metabolomes and transcriptomes of different P. pastoris strains secreting antibody fragments, cell engineering targets were selected. Our working hypothesis that increasing intracellular amino acid levels could help unburden cellular metabolism and improve recombinant protein production was examined by constitutive overexpression of genes related to amino acid metabolism. In addition to 12 genes involved in specific amino acid biosynthetic pathways, the transcription factor GCN4 responsible for regulation of amino acid biosynthetic genes was overexpressed. The production of the used model protein, a secreted carboxylesterase (CES) from Sphingopyxis macrogoltabida, was increased by overexpression of pathway genes for alanine and for aromatic amino acids, and most pronounced, when overexpressing the regulator GCN4. The analysis of intracellular amino acid levels of selected clones indicated a direct linkage of improved recombinant protein production to the increased availability of intracellular amino acids. Finally, fed batch cultures showed that overexpression of GCN4 increased CES titers 2.6‐fold, while the positive effect of other amino acid synthesis genes could not be transferred from screening to bioreactor cultures.
Macrophage cell morphology‐imprinted substrates can modulate mesenchymal stem cell behaviors and macrophage M1/M2 polarization for wound healing applications
Authors: Majidi Mohammad , Pakzad Saeedreza , Salimi Maryam , Azadbakht Abdolnaser , Hajighasemlou Saieh , Amoupour Moein , Nokhbedehghan Zeinab , Bonakdar Shahin , Sineh Sepehr Koushan , Pal Singh Chauhan Narendra , Gholipourmalekabadi Mazaher
Published: September 2023

Mesenchymal stem cells and macrophages (MQ) are two very important cells involved in the normal wound healing process. It is well understood that topological cues and mechanical factors can lead to different responses in stem cells and MQ by influencing their shape, cytoskeleton proliferation, migration, and differentiation, which play an essential role in the success or failure of biomaterial implantation and more importantly wound healing. On the other hand, the polarization of MQ from proinflammatory (M1) to prohealing (M2) phenotypes has a critical role in the acceleration of wound healing. In this study, the morphology of different MQ subtypes (M0, M1, and M2) was imprinted on a silicon surface (polydimethylsiloxane [PDMS]) to prepare a nano‐topography cell‐imprinted substrate with the ability to induce anti‐inflammatory effects on the mouse adipose‐derived stem cells (ADSCs) and RAW264.7 monocyte cell line (MO). The gene expression profiles and flow cytometry of MQ revealed that the cell shape microstructure promoted the MQ phenotypes according to the specific shape of each pattern. The ELISA results were in agreement with the gene expression profiles. The ADSCs on the patterned PDMS exhibited remarkably different shapes from no‐patterned PDMS. The MOs grown on M2 morphological patterns showed a significant increase in expression and section of anti‐inflammatory cytokine compared with M0 and M1 patterns. The ADSCs homing in niches heavily deformed the cytoskeletal, which is probably why the gene expression and phenotype unexpectedly changed. In conclusion, wound dressings with M2 cell morphology‐induced surfaces are suggested as excellent anti‐inflammatory and antiscarring dressings.
Contrast media volume reduction with the DyeVertTM system to prevent acute kidney injury in stable patients undergoing coronary procedures
Authors: Paolucci Luca , De Micco Francesca , Bezzeccheri Andrea , Scarpelli Mario , Esposito Giovanni , Airoldi Flavio , Focaccio Amelia , Briguori Carlo
Published: September 2023

Background

Contrast associated acute kidney injury (CA‐AKI) can lead to an increased risk of adverse events. Contrast media (CM) volume reduction has been advocated as a pivotal strategy to prevent CA‐AKI in stable patients undergoing percutaneous coronary procedures.

Aims

To compare the effectiveness of CM volume reduction with the DyeVertTM system versus conventional strategy in reducing the risk of CA‐AKI.

Methods

We prospectively collected data from 136 patients with stable coronary artery disease at high risk of CA‐AKI treated with left ventricular end diastolic pressure (LVEDP)‐ guided hydration and undergoing interventions with the use of the DyeVertTM (Osprey Medical Inc.) system. Patients previously enrolled in the LVEDP‐guided hydration arm of the “Renal Insufficiency Following Contrast MEDIA Administration triaL III” (REMEDIAL III) were considered as controls. Propensity score was used to perform 1:1 matching to adjust for major confounders. The primary outcome was the occurrence of CA‐AKI, as defined by an absolute increase of creatinine values ≥0.3 mg/dL at 48 h.

Results

Patients in the DyeVert group were treated with a significant lower CM volume (median: 47.5 vs. 84.0 mL, p < 0.001). The trend in creatinine increase was lower (p = 0.004) and the Δ of creatinine (0−48 h) showed a higher drop (−0.18 vs. −0.10 mg/dL, p = 0.036) in the DyeVert group. The risk of CA‐AKI was significantly lower in DyeVert group compared to control group (5.1% vs. 16.8%; odds ratio 0.27, 95% confidence interval [0.12−0.61]).

Conclusions

CM volume reduction with the DyeVertTM system seems to be superior to conventional strategies in reducing the occurrence of CA‐AKI.