bluuebunny/crossref_metadata_2025 huggingface dataset:
Spacecraft with Periodic Mass Redistribution: Regular and Chaotic Behaviour
Authors:   Federal Research Center “Computer Science and Control” of Russian Academy of Sciences, Burov A. A. ,   Moscow Aviation Institute (National Research University), Kosenko I. I. ,   Federal Research Center “Computer Science and Control” of Russian Academy of Sciences, Nikonov V. I.
Published: December 2022

The motion of a spacecraft containing a moving massive point in the central field of Newtonian attraction is considered. Within the framework of the so-called “satellite approximation”, the center of mass of the system is assumed to move in an unperturbed elliptical Keplerian orbit. The spacecraft’s dynamics about its center of mass is studied. Conditions under which the spacecraft rotates about a perpendicular to the plane of the orbit uniformly with respect to the true anomaly are found. Such uniform rotations are achieved using a specially selected rule for changing the position of a massive point with respect to the spacecraft. Necessary conditions for these uniform rotations are studied numerically. An analysis of the nonintegrability of a special class of spacecraft’s rotation is carried out using the method of separatrix splitting. Poincaré sections are constructed for certain parameter values. Several linearly stable periodic motions are pointed out and investigated.
Reducing Rotor Vibrations in Active Conical Fluid Film Bearings with Controllable Gap
Authors:   Orel State University, Kazakov Yu. N. ,   Innopolis University, Kornaev A. V. ,   Orel State University, Shutin D. V. ,   Orel State University, Kornaeva E. P. ,   Orel State University, Savin L. A.
Published: December 2022

Despite the fact that the hydrodynamic lubrication is a self-controlled process, the rotor dynamics and energy efficiency in fluid film bearing are often the subject to be improved. We have designed control systems with adaptive PI and DQN-agent based controllers to minimize the rotor oscillations amplitude in a conical fluid film bearing. The design of the bearing allows its axial displacement and thus adjustment of its average clearance. The tests were performed using a simulation model in MATLAB software. The simulation model includes modules of a rigid shaft, a conical bearing, and a control system. The bearing module is based on numerical solution of the generalized Reynolds equation and its nonlinear approximation with fully connected neural networks. The results obtained demonstrate that both the adaptive PI controller and the DQN-based controller reduce the rotor vibrations even when imbalance in the system grows. However, the DQN-based approach provides some additional advantages in the controller designing process as well as in the system performance.
The impact of sanctions on food security: traditional and new dimensions
Authors: Bartenev V.
Published: December 2022

The article explores an increasingly relevant topic of the impact of the sanction pressure on food security, summarizes and refines the assessments that have gained ground in political and academic discourse by early 2020s. The study first examines the restrictions on food and agricultural products, points at the legal gap that had emerged in this domain during the Cold War, and examines attempts to partially mitigate this gap by means of humanitarian exemptions from the sanction regimes. The range of options for making such exemptions has significantly expanded after the Cold War, but some factors, especially zero risk tolerance and overcompliance by financial institutions, reduce the effectiveness of these exemptions. Key mechanisms of direct and indirect impact of trade and financial sanctions on food security are addressed at the macro-level. The article also focuses on the novel dimensions of the nexus between sanctions and food security that emerged as a result of an escalation of the conflict in Ukraine and the following wave of unprecedented Western sanctions against Russia. In the future, the Western powers can also step up primary and secondary sanctions against those large non-Western powers who act as both suppliers of food products and donors of development programs. This, however, would inevitably have destructive reverse impact on the economies of both third states and sanctioning countries themselves. As a result, the sanctions–food security nexus may become even stronger, which, in turn, may hinder the achievement of food security-related goals and tasks envisaged in Global Sustainable Development Agenda. The only way out of this impasse is to boost parallel efforts to mitigate disruptive consequences of economic sanctions and to create conditions for resolving the conflicts which led to imposing these sanctions.
Time capsule: revisiting American strategies on Afghanistan after theу failed
Authors: Safranchuk I.
Published: December 2022

A plethora of opinions expressed in the U.S. political and expert circles on the intervention in Afghanistan did not produce an answer to the question about the future of the American operation. Amidst this uncertainty, the book by Barnett Rubin and his colleagues revisits some fundamental issues regarding the U.S. war in Afghanistan. The authors’ main idea is that the isolation of Afghanistan impedes its development because the country only partially participates in international division of labor, while lack of development fuels multiple internal contradictions. As a result, the Afghan government lacks the income to provide basic public goods or sustain order. It was argued that the solution is to reintegrate Afghanistan into world economy through development of export industries and to reinforce the central government. In practice, all attempts to strengthen the Afghan government only led to its growing reliance on the United States. However, after the fall of the pro-American regime, the Taliban started to implement the program of reinforcing the central government in Afghanistan, albeit from different ideological positions. The historical paradox will be if the Taliban succeed in this effort where the pro-American regime failed.
Mixed method analysis of violence in North and West Africa
Authors: Rosa V.
Published: December 2022

Borders and Conflicts in North and West Africa. Eds. Marie Trémolières, Olivier J. Walther, and Steven M. Radil. West African Studies. – Paris: OECD Publishing, 2022. 128 p.
Postconflict cities: remnants of war in peace
Authors: Berdimyradova G.
Published: December 2022

Gusic I. Contesting Peace in the Postwar City: Belfast, Mitrovica and Mostar. – New York: Palgrave Macmillan, 2020. 311 p.
TOURISM VOLATILITY TO EXTERNAL SHOCKS
Authors: Herman Suzana
Published: December 2022

International tourism of today is considered one of the main levers of job creation, generating income and foreign currency and foreign investment. Over the past few years, international tourism has been growing steadily, but at the same time this same growth is threatened by challenges in the form of various external shocks affecting the volatility of tourism. Volatility is described, according to many authors, as an unpredictable measure of the intensity of variations. These variations are associated with unpredictable crisis situations or events commonly referred to as ‘new shocks’ (e.g. terrorism, epidemics, natural disasters, exchange rate volatility, oil price, political (in)stability, wars, and various forms of criminal activities). Such global events have a profound impact on a wide range of political, legal and social dimensions. Tourism is extremely vulnerable to various external and internal shock e. The appearance of exogenous events in destinations changes the characteristics of tourism at the destination level, affecting the tourist demand, but also on the economic situation of the country.
IMPLEMENTATION OF VECTOR AUTO-REGRESSION MODELS IN TOURISM: STATE OF THE ART ANALYSIS AND FURTHER DEVELOPMENT
Authors: Gričar Sergej
Published: December 2022

Purpose The dissertation focuses on time series analysis and is based on several research strategies and methods. The methodology used in the research process was published in four papers as part of international scientific journals indexed in the Web of Science database. Since tourism is one of the most lagged industries in science there is need for new and innovative approaches in key tourist sector determinants modelling and forecasting. This doctoral thesis introduces an extension of time series methodology that focuses on investigating and testing the normal distribution of residuals, as a key adequacy prerequisite of econometric models. This issue has not systematically been considered in quantitative approaches in tourism. The motivation for research of the doctoral thesis are multidimensional: to filter previous research on time series in tourism and to theoretically and empirically improve and redesign time series methodology and methods for tourism. Both issues were successfully presented in one of the published papers. Finally, tourism forecasts should be based on reliable models as evident, from the most recent shocks, ex-ante tourism forecasting has to be considered crucial in evaluating model efficiency. The dissertation aimed to research and develop appropriate econometric models able to capture the specifics of multiple interactions in the tourism market. The research seeks to develop econometric models for the Republics of Slovenia and Croatia, two countries whose economic development is predicated on tourism. Four goals and four specific objectives have been specified during the research process: 1) To introduce an improved time series approach in cointegrated panels. The first specific objective (SO1) is to test at least ten econometric modelling structures that reduce cycle breaks. 2) To examine previous theoretical thinking regarding the cointegration of time series, cross-sectional data, and panels. The second specific objective (SO2) is to outline at least 250 previous empirical studies for the tourism industry. 3) To examine cointegration in tourism data for Slovenia and Croatia. The third objective (SO3) is to model at least three econometric time series equations and mathematical theorems/ lemmas for the tourism industry. 4) To improve and better understand unit root tests in tourism. The specific objective (SO4) is to approach the design of at least three stable and innovative models.
A case of symmetrical drug-related intertriginous and flexural exanthema
Authors: Subhadarshani Sweta , Valluri Anisha P.
Published: December 2022

Symmetrical drug-related intertriginous and flexural exanthema (also known as Baboon syndrome) is a skin eruption in the intertriginous areas. It is believed to be a delayed-type hypersensitivity response to the drug which occurs secondary to systemic absorption of agents after cutaneous sensitization. Our case provides high quality clinical images to aid in clinical diagnosis of this uncommon skin eruption.
Genotoxic and chemopreventive potentials of ethanol leaves extract of Annona muricata on N-Ethyl-N-Nitrosourea-induced pro-leukaemia carcinogen in mice model by bone marrow micronucleus assay
Authors: Bamisaye Oluwaseyi , Fashina Anthony , Abdulraheem Fatai , Akanni Olufemi Emmanuel , Olufemi Fadiora S.
Published: December 2022

Background. Studies have proven the effect of several agents, including natural products, to induce, prevent and treat genotoxicity through experimental models and clinical trials. In this study, the genotoxic preventive potential of Annona muricata ethanol extract on N-Ethyl-N-Nitrosourea (ENU)-induced pro-leukaemia in mice models using micronuclei formation in bone marrow was assessed.
Materials and methods. Forty-eight mice weighing 18-24g were randomly divided into six groups of eight mice. The mice were intravenously administered 20mg/kg of NEU 48 hourly 3 times, 80mg/kg of NEU 48 hourly 3 times. The negative control was fed with feed and water only. We introduced 0.2ml (0.1g/ml) ethanolic extract of Annona muricata for 3 weeks prior to NEU low dosage administration, 0.2ml (0.1g/ml) ethanolic extract of Annona muricata for 3 weeks prior to ENU high dosage and Annona muricata (ethanolic extract) administration, and gave commercial diet to the adverse/ toxicity group.  The bone marrow was harvested, smeared and stained using MayGrumwald. The procedure enabled the determination of micronucleus polychromatic erythrocytes (MNPCEs) microscopically.
Results. Groups exposed to various dosages of the ENU yielded significantly increased MNPCEs, with group B producing higher MNPCEs. The groups treated with the extract displayed a significant reduction in the MNPCEs despite prior exposure to concentrations of NEU. The adverse group displayed no difference in MNPCEs compared with the negative control.
Conclusion. The ENU induced genotoxicity depending on its concentration. The extract displayed a profound capacity to prevent genotoxicity and alleviate leukaemia with good tolerance.
Childfree Dalam Pandangan Islam
Authors: Fadhilah Eva
Published: December 2022

Childfree menjadi sebuah isu yang hangat diperbincangkan dikalangan masyarakat khususnya pasangan muda. Childfree adalah sebuah kesepakatan yang dilakukan oleh pasangan suami isteri untuk tidak memiliki anak selama masa pernikahannya. Padahal selama ini dalam kontruksi budaya masyarakat Indonesia, anak dianggap sebagai satu anugrah yang berfungsi sebagai perekat keharmonisan sebuah keluarga sehingga kehadirannya senantiasa dinanti-nantikan oleh pasangan yang sudah menikah bahkan keluarga besarnya. Dengan pendekatan normatif al-Qur’an dan Sunnah dapat diketahui bahwa memiliki keturunan adalah sebuah anjuran dalam Islam bukanlah sebuah kewajiban. Sehingga childfree tidak termasuk pada kategori perbuatan yang dilarang,  karena setiap pasangan suami istri memiliki hak untuk merencanakan dan mengatur kehidupan rumah tangganya termasuk memiliki anak. Kendati demikian, meski tidak ada ayat yang secara langsung melarang childfree, sebagai manusia yang meyakini Allah SWT, pilihan untuk childfree bisa dikatakan sebagai pilihan yang tidak bijaksana karena Allah SWT menjamin kelangsungan hidup setiap hambanya. Tegas disebutkan bahwa dalam Islam anak dipandang sebagai anugrah yang harus disyukuri karena anak adalah pemberian Tuhan. Setiap manusia yang diberikan amanah menjadi orangtua harus menjalani peran tersebut dengan baik dan totalitas.Kata kunci :  Childfree, Hukum Islam, Anak, Pernikahan, Al-Qur’an dan Sunnah
The Visual Activism of Street Signs and the Legacy of Marielle Franco: Disseminations, Controversies, and Resistance around the Globe
Authors: Meireles Flavia Pinheiro
Published: December 2022

This article examines the street signs that carry the name of Brazilian Black Lesbian Leftist politician Marielle Franco, who was killed on March 14, 2018, in what is a still unresolved case. In exploring the many street signs made with her name as a form of protest, remembrance, homage to her legacy and visual activism, I explore what might be considered ‘Franco’s after-life’; a series of visual actions that occurred after her killing. I analyse the emerging context and dissemination of these street signs, their circulation not only on the streets and in leftist protests, but also on social media and in art spaces, and their global reach. I will also address the breaking of Franco’s street sign, as a form of backlash from politicians aligned with far right-wing politics. Franco mobilized intersectional agendas of race, class, geography, gender, and sexuality in her political struggles within parliament, during her term as a minority force in the Rio de Janeiro parliament. I aim to theorize the cultural practices that support the dissemination of these images, the effect of their visuality, and the complex network formed around them. At stake is also the question of visibility, and the circulation of the street signs in an international space, crossing national borders and facing the emergence of far right-wing movements worldwide. This article will foreground the importance of street signs as anonymously produced expressions of collective action and aesthetical-political action. Speaking from global Southern geographies, the analysis also reflects on challenges, visibilities, and erasures of Black Lesbians in different contexts. Lastly, I consider the Marielle Franco street signs as a site of transnational Black feminist theoretical possibility for delineating the diasporic.
A Complex Landscape of Fun, Queerness and Desire in China: Introducing Three Films by He Xiaopei
Authors: Wang Xiying
Published: December 2022

This article documents He Xiaopei’s work as a film activist who contributes significantly to feminist and queer movements in contemporary China. Trained as a social scientist, He Xiaopei then went on to become the director of the civil organization Pink Space Research Center in the mid-2000s as well as an independent filmmaker. Since 2010, she has produced more than ten documentary movies. However, despite the greatness of her contribution, the range of the topics she has covered, and her position in the feminist and queer movement in China, she has yet to receive the attention she deserves in English-speaking academia. This article selects three movies by He Xiaopei, i.e., The Lucky One, Playmates, and Bad Women of China, and provides an intersectional analysis of gender, friendship, migration, sexuality and intimate relationships, as seen through the lens of an ever-changing China on the global stage. At first glance, the three movies focus on different figures and themes, but they share the same core spirit – breaking through boundaries and limits, maintaining humour and positivity even when facing predicaments, embracing desire and depicting humanity as it manifests in complicated modern life.
The Transgender Flipping Point: How Trans Instagrammers Flip the Script on Identity
Authors: Lehner Ace
Published: December 2022

Since Time magazine’s now iconic 2014 cover story featuring trans actress Laverne Cox proclaimed the contemporary moment ‘The Transgender Tipping Point’, there has been much debate about the recent proliferation of trans representations across all media sectors. Trans scholars, culture producers, artists, and activists have argued that this is not only a misconception, but it occludes the corpus of trans visual culture made by and for trans culture producers reflecting a wider diversity of trans experiences that do not readily reflect dominant cultural paradigms. Defined as a self-image made with a hand-held mobile device and shared via social media platforms, the selfie has facilitated self-imaging becoming a ubiquitous part of globally networked contemporary life. Beyond this, selfies have facilitated a diversity of image-making practices and enabled otherwise representationally marginalized constituencies to insert self-representations into visual culture. A close look at the prolific selfie practice of Black British, gender-non-conforming, trans-femme performance artist Travis Alabanza reveals their use of Instagram to be a critical intervention into contemporary culture. In self-imaging complex, expansive, and intersectional identity, Alabanza’s oeuvre produces new visual exemplars that defy stereotypes and erasures produced by dominant culture while simultaneously challenging our previously held conceptions of identity and self-portraiture. Alabanza’s work decolonizes the relationship between the subject and the portrait, encouraging viewers to consider the complex dialectical relationship between images, aesthetics, and communication about identity, performativity, gender, racialization, class, and subcultural affiliations.
Queer Data: Using Gender, Sex and Sexuality Data for Action
Authors: Ellis Sarah Jayne
Published: December 2022

Review of the book "Queer Data: Using Gender, Sex and Sexuality Data for Action" by Kevin Guyan.
Modification of Sympathetic and Hypothalamic Responses to Prevent Complications of COVID-19 “Dam and Wall Concept”
Authors: Hyoju Sanjiv K.
Published: December 2022

We are in amidst of COVID-19 pandemic. Since Dec 2019, severe acute respiratory corona virus (SAR-CoV-2) has infected more than half a billion people killing nearly 7 million people worldwide. Now the BA.5 variant of SARS-CoV-2 is causing mayhem and driving the global surge. Epidemiologist are aware of the fact that this virus is capable of escaping immunity and likely to infect the same person multiple times despite adequate vaccination status. Elderly people of age more than 60 years and those with underlying health conditions are considered as high-risk who are likely to suffer complications and death. While it is tempting to frame complications and mortality from COVID-19 as a simple matter of too much of a virulent virus in too weak of a host, much more is at play here. Framing the pathophysiology of COVID-19 in the context of the Chrousos and Gold model of the central stress response system can shed insight into its complex pathogenesis. Understanding the mechanisms by which pharmacologic modulation of the central stress response system via administration of clonidine and/or dexamethasone may offer an explanation as to why a viral pathogen can be well tolerated and cleared by one host while inflaming and killing another.
Outcomes of Total Elbow Arthroplasty in Trauma Patients Compared with Patients Following Fixation of Distal Humerus Fractures
Authors: Maman David , Weishahe Nada , Norman Doron , Keren Yaniv , Yelton Mitchell , Trior Yaniv , Apt Elad Apt , Peskin Bezalel , Ghrayeb Nabil , Shapira Jacob
Published: December 2022

Background and purpose: Total elbow arthroplasties (TEA) aim to replicate anatomy and provide stability in the treatment of distal fractures of the humerus. In the presence of an aging population with higher functional demand, improving patients’ well-being is crucial. This study aimed to analyze patients’ reported outcomes and functional outcomes for TEA in comminuted fractures of the distal humerus and to compare these outcomes with their counterpart patients who have been treated with open reduction and internal fixation (ORIF). In addition, this study aims to compare the secondary procedures rate between the two groups.Patients and Methods: Eligible patients were those who underwent TEA or ORIF of the distal humerus and completed several patient-reported outcome (PRO) questionnaires including the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, 12-Item Short Form Health Survey Physical and Mental components (SF-12 P and SF-12 M, respectively) scores, visual analog scale (VAS) score for pain, and patient satisfaction ratings (1-5). A physical examination including range of motion, instability, and strength was performed for all patients. Results: This study found that patients following TEA have shown significantly lower pain levels (TEA: 3.72±2.8; ORIF 5.2±2.98, P=0.019) and higher satisfaction levels (TEA: 4.18±1.17; ORIF 3.57±1.46, P=0.035) compared with patients following ORIF. DASH score (TEA: 33.7±29.4; ORIF 39.75±24.6, P=0.31) and SF-12 score (TEA: 31.7±9.67; ORIF 31.25±10.2, P=0.85) were not statistically different between TEA and ORIF.Patients following TEA have demonstrated an advantage in flexion compared with patients following ORIF (P=0.045). Both patients following TEA and ORIF demonstrated no statistically significant difference in pronation and supination of the operated elbow compared to the contralateral side. Although, a decreased range in extension and flexion of the operated elbow compared with the contralateral side was demonstrated in both groups (extension P=0.005, flexion P<0.001). The grip Test showed no significant difference between the patients who were treated by TEA or ORIF (P=0.99). Moreover, ORIF in comminuted fractures of the distal humerus in elders may be associated with a higher complication rate compared with TEA.Conclusion: TEA following comminuted fractures of the distal humerus is associated with favorable satisfaction, pain levels, and range of motion in flexion compared with patients following ORIF of the distal humerus. Additionally, TEA may be associated with a lower rate of secondary procedures.
Does the Potocki-Lupski Syndrome Convey the Autism Spectrum Disorder Phenotype? Case Report and Scoping Review
Authors: Talantseva Oksana I. , Portnova Galina V. , Romanova Raisa S. , Martynova Daria A. , Sysoeva Olga V. , Grigorenko Elena L.
Published: December 2022

Potocki-Lupski Syndrome (PTLS) is a rare condition associated with a duplication of 17p11.2 that may underlie a wide range of congenital abnormalities and heterogeneous behavioral phenotypes. Along with developmental delay and intellectual disability, autism-specific traits are often reported to be the most common among patients with PTLS. To contribute to the discussion of the role of autism spectrum disorder (ASD) in the PTLS phenotype, we present a case of a female adolescent with a de novo dup(17)(p11.2p11.2) without ASD features, focusing on in-depth clinical, behavioral, and electrophysiological (EEG) evaluations. Among EEG features, we found the atypical peak-slow wave patterns and a unique saw-like sharp wave of 13 Hz that was not previously described in any other patient. The power spectral density of the resting state EEG was typical in our patient with only the values of non-linear EEG dynamics: Hjorth complexity and Fractal dimension were drastically attenuated compared with the patient’s neurotypical peers. Here we also summarize results from previously published reports of PTLS that point to the about 21% occurrence of ASD in PTLS that might be biased, taking into account methodological limitations. More consistent among PTLS patients were intellectual disability and speech and language disorders.
Are Saudi Healthcare Workers (HCW) Willing to Receive the Monkeypox Virus Vaccine?
Authors: M. Alarifi Abdullah , Alshahrani Najim Z. , Sah Ranjit
Published: December 2022

Early experience with Covid-19 shows that vaccines can be the most effective way of preventing the spread of infection. However, vaccine hesitancy is among the most significant hurdles in preventing the spread of novel infections. Monkeypox (MPX) has already been declared a global health emergency by WHO. Thus, there is an urgent need to understand the MPX vaccine willingness in various population groups. In this cross-sectional study, an online survey was conducted among Saudi healthcare workers (HCWs) to understand the monkeypox vaccine willingness in healthcare workers in Saudi Arabia. Saudi has already confirmed multiple MPX cases, and thus it is essential to initiate timely protective measures, including vaccination. The study had 743 respondents. The study found that among Saudi HCWs, 52.7% were willing to receive the MPX vaccine. The study found that sociodemographic factors had a small impact on vaccine willingness. However, early experience with vaccination had a significant impact. Thus, more than 70% who had influenza or COVID-19 vaccine were willing to receive the MPX vaccine. Some of the most significant concerns influencing vaccine acceptability were the safety and efficacy of the vaccine. Hence, it is strongly recommended to focus on disseminating information regarding the safety and efficacy of the MPX vaccine.
The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAMs) in Pharmaceuticals and Environmental Chemical Risk Assessment
Authors: Deepika Deepika , Kumar Vikas
Published: December 2022

Physiologically Based Pharmacokinetic Models (PBPK) are mechanistical tools generally employed in the pharmaceutical industry and environmental health risk assessment. These models are recognised by regulatory authorities for predicting organ concentration-time profile, pharmacokinetic and daily intake dose of xenobiotics. Extension of PBPK models to capture sensitive populations like pediatric, geriatric, pregnant females, fetus etc. and diseased population like renal impairment, liver cirrhosis etc. is a must. However, the current modelling practice and existing models are not mature enough to confidently predict the risk in these populations. A multidisciplinary collaboration between clinicians, experimental and modeler scientist is vital to improve the physiology, and calculation of biochemical parameters for integrating the knowledge and refining existing PBPK models. Specific PBPK covering compartments like cerebrospinal fluid, and hippocampus are required to gain mechanistic understanding about xenobiotic disposition in these sub-parts. The PBPK model assists in building quantitative adverse outcome pathways (qAOPs) for several endpoints like developmental neurotoxicity (DNT), hepatotoxicity and cardiotoxicity. Machine learning algorithms can predict physicochemical parameters required to develop in-silico models where experimental data is unavailable. Integrating machine learning with PBPK carries the potential to revolutionize the field of drug discovery and development and environmental risk. Overall, this review tried to summarize the recent developments in the in-silico models, building qAOPs, use of machine learning for improving existing models along with a regulatory perspective. This review can act as a guide for toxicologists who wish to build their careers in kinetic modeling.
A Scoping Review of Digital Wellbeing in Early Childhood: Definitions, Measurements, Contributors, and Interventions
Authors: Cao Simin , Li Hui
Published: December 2022

Digital wellbeing concerns the balance and health we may experience in digital use, and the existing studies have focused on adolescents and adults. However, young children are more vulnerable to digital overuse and addiction than adults; thus, their digital wellbeing deserves empirical exploration. This scoping review synthesized and evaluated 35 collected studies on young children’s digital use and their wellbeing that were published until October of 2022 to understand the definitions, measurements, contributors, and interventions. The synthesis of evidence revealed that: (1) there was no consensus about its definition; (2) there were no effective measurements of young children’s digital wellbeing; (3) both child factors (duration and place of digital use, child demographic characteristics) and parent factors (digital use, parental perception, and mediation) contribute to young children’s wellbeing; and (4) there were some effective applications and interventions. This review contributes to the theoretical development by mapping the existing work on young children's digital wellbeing, proposing a model, and identifying the research gaps for future studies.
Adaptive Multi-Scale Fusion of Image Deblurring Networks for Drone and Aerial Remote Sensing Object Detection
Authors: Zhu Baoyu , Lv Qunbo , Tan Zheng
Published: December 2022

Drone and aerial remote sensing images are widely used, but their imaging environment is complex and prone to image blurring. Existing CNN deblurring algorithms usually use multi-scale fusion to extract features in order to make full use of aerial remote sensing blurred image information, but images with different degrees of blurring use the same weights, leading to increasing errors in the feature fusion process layer by layer. Based on the physical properties of image blurring, this paper proposes an adaptive multi-scale fusion blind deblurred generative adversarial network (AMD-GAN), which innovatively applies the degree of image blurring to guide the adjustment of the weights of multi-scale fusion, effectively suppressing the errors in the multi-scale fusion process and enhancing the interpretability of the feature layer. The research work in this paper reveals the necessity and effectiveness of a priori information on image blurring levels in image deblurring tasks. By studying and exploring the image blurring levels, the network model focuses more on the basic physical features of image blurring. Meanwhile, this paper proposes an image blurring degree description model, which can effectively represent the blurring degree of aerial remote sensing images. The comparison experiments show that the algorithm in this paper can effectively recover images with different degrees of blur, obtain high-quality images with clear texture details, outperform the comparison algorithm in both qualitative and quantitative evaluation, and can effectively improve the object detection performance of aerial remote sensing blurred images. Moreover, the average PSNR of this paper's algorithm tested on the publicly available dataset RealBlur-R reached 41.02dB, surpassing the latest SOTA algorithm.
Mass Spectrometry-Based Techniques Towards OMICS 2.0
Authors: Šoša Ivan
Published: December 2022

The literature was scoped to help place mass spectrometric (MS) platforms in the spotlight of the life sciences, as a tool of OMICS and OMICS 2.0 technologies. These methods were discussed, and their feasibility was highlighted in many reviews that have been periodically published, in addition to the most recently developed term OMICS 2.0. This author’s primary interest was the forensic application of MS, but since these interests got broadened, terms such as “biosensors” were also included. So, means of discovery of efficient biomarkers and clinical therapeutic targets were also reviewed. However, within the framework of this review, physical chemistry, bioinformatics, or specific software solutions were not specifically scoped. Aside from simply reviewing the research status and the future perspectives, this article tackles terms such as Society 5.0 and OMICS 2.0. Since the topic of generating permanent collections of digital content for retrospective analysis was reviewed, what requires loads of data – cloud storage is discussed in the context of MS. In this manner, the review has strengthened an in-depth understanding of the applications of MS. These large quantities of data are easier to operate with if generated by MS, rather than by any other commercially available assay.
Exploitation of Non-Timber Forest Products in the Eastern Part of DR Congo
Authors: MUGISHO Serge MUKOTANYI , Muhindo Daniel Iragi , Balezi Alphonse Zihalirhwa , Ndeko Julien Bahizire , Imani Gérard Mugisho , Teteli Clément Soloum , Cizungu Landry Ntaboba
Published: December 2022

Forests are a large reservoir of biodiversity on which riparian populations frequently rely. Non-timber forest products (NTFPs) are an important source of income for millions of people living in forest-adjacent communities. This study aims at characterizing the types and uses of NTFPs in order to determine whether their exploitation in the eastern Democratic Republic of the Congo is sustainable. Interviews and direct observation were carried out with NTFP stakeholders (harvesters, sellers, and consumers) in Kalonge, near the Kahuzi-Biega National Park. The results showed that 40 NTFPs of plant origin and 10 NTFPs of animal origin are commonly exploited and used in food and traditional medicine. The most common NTFP harvesting techniques are debarking, picking, digging up, felling, and wine extraction, which are all tailored to the plant part. A significant relationship (p-value< 0.001) has been established between the types of NTFPs used and harvesting methods as well as between the types of NTFPs used and organs retrieved. NTFP products are mainly obtained from the natural forest KBNP but also in the woodland, trees grown outside of forest or through domestication. Their abundance, however, is hampered by the extraction of wood for charcoal, energy, and timber, as well as agricultural expansion. The supply of NTFPs is determined by the market demand for the products, the nature of the product, and the ease of disposal. The NTFPs value chain in Kalonge is important to the local economy, however exploitation of NTFP products remains uncontrolled and should be well managed to ensure sustainability.
Endometrioid cystadenoma – deep ovarian endometriosis
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Davydov A.I. , Mikhaleva L.M. ,   A.P.Avtsyn Research Institute of Human Morphology, Moscow, Russian Federation, Khabarova M.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Chilova R.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lebedev V.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: December 2022

Among all endometriosis lesions of female reproductive organs, ovarian endometrioma is the most discussed nosology. Since 2014, ovarian endometrioid cysts have been classified as benign tumors (WHO Classification of Tumours of Female Reproductive Organs, 4th edition). In 2021, the 11th revision of the International Classification of Diseases (ICD-11) was amended, according to which the term “endometrioid ovarian cyst” (from 2018 to 2021 – heading GA18.3 Ovarian endometriotic cyst, section GA18 Acquired abnormalities of ovary) is no longer used, and the clinical and morphological signs of these cysts are presented in the heading GA10.B5 Deep ovarian endometriosis. In 2020, WHO updated the histological classification of female genital tumors (Female Genital Tumours WHO Classification of Tumours, 5th Edition), in which the section “endometrioid tumors” is presented only with endometrioid cystadenoma and endometrioid adenofibroma without mentioning the endometrioid cyst, but in accordance with the ICD-11, endometrioid cystadenoma is coded as “GA10.B5 Deep ovarian endometriosis”. Thus, on the one hand, ovarian endometrioma is a neoplastic process and requires appropriate approaches when choosing treatment tactics, on the other hand, cystectomy for endometrioma is accompanied by a pronounced loss of ovarian reserve. A possible consensus in this problem seems to be a minimally invasive method in the treatment of patients with ovarian endometriomas – ethanol sclerotherapy with cytological examination of the aspirate obtained from the neoplasm. The effectiveness of sclerotherapy largely depends on the choice of postoperative hormonal therapy. Today, dienogest is considered to be the most effective “anti-endometrioid” progestogen. However, there is an erroneous opinion that ethinylestradiol neutralizes the antiproliferative effect of dienogest and stimulates the growth of endometriosis. On the contrary, ethinylestradiol enhances the inhibitory effect of progestogen on the growth of ovarian endometrioma cells. Key words: endometrioid cystadenoma, ovarian endometrioma, deep ovarian endometriosis, sclerotherapy, dienogest
Recurrence of deep infiltrating endometriosis with urinary tract involvement
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Bryunin D.V. , Enikeev M.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Bakhvalova A.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Alieva Farakh T. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Alieva Fidan T. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Khokhlova I.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Dzhibladze T.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gadaeva I.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Chushkov Yu.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Asambaeva A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ishchenko A.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: December 2022

This article presents a clinical follow-up of a 41-year-old patient with the recurrence of deep infiltrating endometriosis affecting the urinary tract. A multidisciplinary approach to examination and treatment contributed to the successful outcome of laparoscopic surgery, which included adhesiolysis, resection of the left ovary, excision of endometrioid infiltrates in the left parametrium, rectovaginal septum and vagina, posterior wall of the urinary bladder, left ureterocystostomy. The dynamic 6-month follow-up revealed no signs of recurrence of the disease and upper urinary tract dilatation, which made it possible to start preparing for next pregnancy. Key words: recurrence of deep infiltrating endometriosis, multidisciplinary approach, laparoscopy, excision of multifocal endometrioid infiltrates, ureterocystostomy
Effectiveness of medical therapy for preventing ovarian endometriosis recurrence after surgical treatment
Authors:   Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation, Orazov M.R. , Radzinsky V.E. ,   Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation, Orekhov R.E. ,   Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation, Tairova M.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: December 2022

Objective. To study the effectiveness of therapy with dienogest (Zafrilla) in the prevention of ovarian endometriosis recurrence after surgical treatment. Patients and methods. This prospective observational comparative study enrolled 104 patients aged 20 to 49 years with morphologically verified diagnosis of ovarian endometriosis. Patients were divided into groups. Group 1 (n = 82) received postoperative therapy with dienogest (Zafrilla) (2 mg once daily for 24 weeks); group 2 (n = 22) did not receive postoperative hormonal therapy. The duration of postoperative follow-up was 12 months. Results. The recurrence rate of ovarian endometriosis within 12 months was 1.22% (1 out of 82) in group 1 and 22.7% (5 out of 22) in group 2. Against the background of postoperative therapy with dienogest in group 1, there was a statistically significant decrease in the average pain intensity and its transformation from moderate to mild after 3 months of therapy (2.5-fold on average) and to mild or complete relief after 6 months (5-fold on average, compared to the values before therapy), according to pain assessment scales (NRS, VAS). Group 2 showed a statistically significant increase in the average pain intensity on all scales and no statistically significant change in serum concentrations of the examined markers (IL-17, IL-6, IL-10, TNF-α), while group 1 demonstrated a statistically significant decrease in serum concentrations of all the examined inflammatory markers and the CA-125 marker. Conclusion. Dienogest (Zafrilla) can be considered as the main therapeutic approach for the long-term prevention of ovarian endometriosis recurrence after surgical treatment. Key words: endometriosis, ovarian endometriomas, pelvic pain, dienogest, quality of life, inflammatory markers
Horner's syndrome a child after surgery for spontaneous pneumothorax: a case report
Authors:   Tver State Medical University, Tver, Russian Federation, Burovnikova A.A. ,   Children’s Regional Clinical Hospital, Tver, Russian Federation, Rumyantseva G.N. ,   Tver State Medical University, Tver, Russian Federation, Yusufov A.A. ,   Tver State Medical University, Tver, Russian Federation, Brevdo Yu.F. ,   Children’s Regional Clinical Hospital, Tver, Russian Federation, Trukhachev S.V. ,   Children’s Regional Clinical Hospital, Tver, Russian Federation, Svetlov V.V. ,   Children’s Regional Clinical Hospital, Tver, Russian Federation, Kazakov A.N. ,   Tver State Medical University, Tver, Russian Federation,   Children’s Regional Clinical Hospital, Tver, Russian Federation
Published: December 2022

In this article we present a case of Horner syndrome in a teenager occurring with thoracoscopic treatment for spontaneous pneumothorax. Horner's syndrome is a rare pathological condition caused by a lesion of the sympathetic nervous system responsible for the innervation of the eye. A brief review of the available literature data on the occurrence of this complication in spontaneous pneumothorax, its etiopathogenesis, and clinical manifestations is presented. The anamnesis, clinical picture, instrumental studies, stages of operation of this clinical case are described in detail. It is assumed that Horner's syndrome is associated with tissue damage near the stellate ganglion and nerve fibers during physical pleurodesis by argon-plasma coagulation. Key words: children, pleurodesis, Horner syndrome, spontaneous pneumothorax
Current trends in the treatment of acute tonsillophayngitis in children
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Ilyenko L.I. , Garashchenko T.I. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation,   Research and Clinical Center for Otorhinolaryngology of the Federal Medico-Biological Agency, Moscow, Russian Federation, Payganova N.E. ,   LLC “Doctor Zaitsev’s ENT Clinic”, Moscow, Russian Federation
Published: December 2022

Sore throat is one of the most common reasons for going to a primary care doctor and at the same time self-medicating with antibiotics. The main task of a pediatrician at an outpatient appointment is first of all to understand how to help a child (that is, to reduce pain) in order to improve his quality of life. Determining the streptococcal nature of the disease for the appointment of antibacterial therapy is a matter of prescribing systemic antibacterial therapy. In the treatment of acute tonsillopharyngitis, it is relevant to use safe and effective means as part of complex therapy to shorten the duration of the disease, reduce the risk of complications, prevent relapses and improve the quality of life. The integration of homeopathic medicines into complex treatment regimens makes it possible to increase their effectiveness and reduce the drug load. The use of homeopathy in the Russian Federation is permitted and regulated by law. Of the complex homeopathic preparations intended for the treatment of acute and chronic inflammatory diseases of the lymphopharyngeal ring, Tonsilotren is the most studied. The drug is organotropic, because its composition includes components that have maximum tropicity to the lymphoid tissue of the tonsils. Tonsilotren® is a highly effective and safe drug that can be used as part of the complex therapy of both acute tonsillopharyngitis and exacerbations of chronic tonsillitis. The drug has a pronounced positive effect on the relief of local signs of tonsillitis, as well as on improving the general condition of patients with pathology of the lymphopharyngeal ring, which has been proven both in experiment and in a series of clinical studies. Key words: tonsillar pathology, acute tonsillopharyngitis, targeted drugs
STRATEGI PENGEMBANGAN PARIWISATA BERBASIS CHSE DI ISTANA MAIMUN
Authors: Khairi Nurhafizhah , Brsinamo Putri Ani , Berliani Ika , Bintang Bintang , Vrichillya Nadya
Published: December 2022

Pandemi Covid 19 yang tengah mengguncang dunia saat ini memberikan dampak yang besar bagi banyak sektor, termasuk juga dalam sektor Pariwisata. Pada pandemi sekarang ini sekor Pariwisata menjadi sektor paling tertekan hal ini dapat dilihat dari penurunan kunjungan wisatawan dan juga penutupan Objek` wisata. Tetapi pemerintah khususnya Kementerian Pariwisata berusaha untuk menjalankan pariwisata kembali dalam siap untuk menghadapai pariwisata pasca pandemi mengeluarkan Kebijakan CHSE (Clean, Health, Safety & Environment). Penelitian ini bertujuan untuk mengetahu tentang wisata berbasis CHSE. Metode penelitian menggunakan metode kualitatif dengan memanfaatkan analisis SWOT. Berdasarkan hasil penelitian menggunakan Analisis SWOT   (Strength, Weakness, Opportunity, dan Threat) dapat di ketahui bahwa di Istana Maimun sudah memiliki tekad yang kuat dalam penerapan wisata CHSE. Sumber Daya di Istana Maimun juga sudah melakukan pelatihan khusus yang langsung dilaksanakan oleh pihak terkait ( Pemerintah, Dinas Pariwisata, Kementerian Pariwisata dan Ekonomi Kreatif) secara proaktif.

 

 