bluuebunny/crossref_metadata_2025 huggingface dataset:
The Literacy We Teach Today
Authors: Van der Weel A.
Published: February 2024

The article discusses the issues of text culture transformation, literacy and reading. The purpose of the article is to explore the modern interpretation of the concept of "literacy" and determine its place in creating the shape of tomorrow’s world. The author analyzes the changes in the culture of reading and literacy education that resulted from the introduction of massive educational reforms in Western Europe. The author reminds us that literacy and our reading culture are not givens but that they constantly evolve under the influence of new text technologies. The author tries to comprehend the consequences of the current digital media revolution for intellectual development and the future structure of society; to identify new features that reading and literacy have acquired in modern culture. Besides, considerable attention is paid to the place of text in the digital age. The author concludes that the parallel presence of all mediums on the same screen suddenly showed the real place of text in people’s affections. Being cognitively more demanding, text clearly takes second position to auditory and visual media for entertainment and as a vehicle of cultural experience. Meanwhile the social use of text in the meantime is a different matter: text is still very important in social media – although in an ever more rudimentary form. Author concludes that none of the new mediums were ever regarded as a serious threat to books and other text forms. Reading and writing had as it were simply “got their first”. Books could pride themselves on a centuriesold tradition, and when film, radio and television came along, all subjects had already been properly described in (text-) books. The author highlights that the “screen effect” leading to the demotion of such more demanding forms of reading clearly shows once again the contingent nature of literacy. What follows is a plea to give back to literacy its original aura as a major intellectual achievement: a means to shape future minds, and thus the society in which our children will live. Based on previous research, the author draws our attention to the fact that digital media revolution is already having the effect of devaluing reading as a cultural technique. It has been generally accepted that schools should include “digital literacy” in the curriculum - even though there is little agreement what position it should take (purely practically and philosophically). In conclusion, the author emphasizes that the future of the literacy project still comes down to overcoming the social and digital divide.
Identification and Validation of T Cell Exhaustion Signature for Predicting Prognosis and Immune Response in Pancreatic Cancer by Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data
Authors: Zhu Yaowu , Tan Li , Luo Danju , Wang Xiong
Published: February 2024

Purpose: Pancreatic cancer (PAAD) is one of the most lethal malignancies. Immunotherapy is largely ineffective in PAAD. T-cell exhaustion contributes to the resistance for immunotherapies. We investigated the prognostic potential of T cell exhaustion-related genes (TEXGs). Methods: Single-cell RNA (scRNA) sequencing dataset from TISCH, and bulk sequencing datasets from TCGA and GTEx were applied to screen differently expressed TEXGs. Kaplan-Meier survival, LASSO regression, and Univariate/Multivariate Cox regression analysis were performed to construct TEXGs risk model. This model was used to predict the prognosis, tumor immune microenvironment, and immunotherapy response. PAAD cohorts from ICGC and GSE71729 datasets were used to validate this risk model. Pan-cancer expression of SPOCK2 was performed in TISCH database. Results: A six-gene (SPOCK2, MT1X, LIPH, RARRES3, EMP1, and MEG3) risk model was constructed. Low-risk PAAD patients had longer survival time in both training dataset (TCGA-PAAD, n=178) and validation datasets (ICGC-PACA-CA, ICGC-PAAD-US, and GSE71729, n=412). Multivariate Cox regression analysis demonstrated that the risk score was an independent prognostic variable for PAAD. High-risk patients correlated with cancer-related KEGG pathway enrichment, higher mutation frequency of KRAS and TP53 genes, and immunosuppressive status. Immunohistochemistry staining confirmed the changes of TEXGs in clinical samples. Moreover, pan-cancer scRNA sequencing datasets from TISCH analysis indicated that SPOCK2 might be a novel marker of exhausted CD8+ T cells. Conclusion: In conclusion, we established and validated a T cell exhaustion-related prognostic signature for PAAD patients. Moreover, our study suggests that SPOCK2 may be a novel marker of exhausted CD8+ T cells.
Irrigated Agriculture Facing the Challenge of Climate Change: What Adaptation Strategies for Farmers in the Irrigated Perimeters of Môle Saint-Nicolas, Haiti?
Authors: Mial Frantz , Bissonnette Jean-François , Bourgault Marc-André , Qacami Meryem
Published: February 2024

Môle Saint-Nicolas, like all other communes in the Republic of Haiti, faces increasing climate variability, impacting agricultural production and water resources. Consequently, there is a pressing need for adaptation to these climatic changes. This research aims to showcase the adaptation strategies deployed by farmers to cope with the increasing climate variability. Surveys were conducted through group and individual discussions with a randomly selected cohort of 150 farmers. Two types of analysis were performed: quantitative and qualitative. The quantitative data analysis was conducted using SPSS software. The findings reveal that farmers have perceived changes in rainfall patterns, temperature, wind, and their environment. These changes manifest as irregular rainfall, higher temperatures, prolonged drought periods, violent winds accompanied by rain, premature cessation of rains, and reduced flow from water sources. In response, the most common adaptation strategies developed include selecting new cultivars, early-maturing varieties, crop rotation and diversification, canal dredging, new soil preparation methods, upstream water source protection, and micro-watershed management. The significance of this research lies in its contribution to enhancing farmers' adaptive capacities by alerting stakeholders in the irrigated perimeters about the consequences of climate change, thereby incorporating the real needs of farmers in future projects.
Efficacy of Floating-Dielectric Barrier Discharge Plasma against Staphylococcus aureus and Salmonella Typhimurium on Fried Fish Paste
Authors: Kim So Hee , Roy Pantu Kumar , Jeon Eun Bi , Park And Shin Young
Published: February 2024

In this study, we evaluated the antibacterial effect against Staphylococcus aureus and Salmonella Typhimurium in fried fish paste using floating electrode-dielectric barrier discharge (FE-DBD) plasma (1.1 kV, 43 kHz, N2 1.5 m/s, 1-60 min). In addition, quality evaluation (pH, VBN) of fried fish paste was conducted after FE-DBD plasma treatment. When FE-DBD plasma was treated for 1, 5, 10, 20, 30 and 60 min, S. aureus decreased by 0.16-1.13 log10 CFU/g, and S. Typhimurium decreased 0.25-1.13 log10 CFU/g. Both decreased > log10 CFU/g at 60 min. The D-value was 58.92 and R2 was 0.97 for S. aureus using first-order kinetics, and the D-value was 43.60 and R2 was 0.97 for S. Typhimurium using the Weibull model. There was no significant difference in pH after FE-DBD plasma treatment (p > 0.05). However, volatile basic nitrogen (VBN) significantly decreased as the treatment time increased (p < 0.05), and it was the lowest at 60 min to 3.46. Therefore, FE-DBD plasma treatment could be considered as a technology for preserving the quality of processed foods.
Salmonella typhimurium Alteration of Small Intestine Metabolism Early after Infection Is Linked to Microbiome Changes
Authors: Entrenas-García Carmen , Argüello Héctor , Calderón-Santiago Mónica , Priego-Capote Feliciano , Zaldívar-López Sara , Garrido Juan J.
Published: February 2024

Salmonella Typhimurium infection in pigs is characterized by an intense inflammatory response in early infection which seems to dysregulate host physiology including the gut microbiota. Both, changes in host physiology and microbiome composition, must entail modifications within the gut environment. This study analyzes the gut metabolome in early infected pigs (48 hours after infection) and non-infected controls by untargeted metabolomics (LC–QTOF MS/MS and GC–TOF MS), supported with microbiome data (16S rRNA abundance and prediction functional analyses). The metabolomic profile in Salmonella-infected pigs differed from healthy controls in 39 of these metabolites, including eight amino acids, four bile acids and carboxylic acids, three carnitines and sugar derivates, eleven fatty acids and six other compounds. Changes in amino acids abundance and the observed decrease of proteolytic bacteria such as Lactobacillus or Bacteroides could favor the niche colonization by Desulfovibrionaceae. In addition, the decrease in short chain fatty acids and tricarboxylic acids cycle was correlated to a decrease in beneficial bacteria in infected pigs. Interestingly, we observed an increase of bile acids concentration and compounds such as succinic acid or pantothenic acid, which may boost the inflammatory response. Altogether, the results reveal how S. Typhimurium infection alters the gut microbiome composition and prompts changes in the metabolism with a potential interaction between intestinal metabolism and microbiota abundance.
A Review of Current Trends, Techniques, and Challenges in Large Language Models (LLMs)
Authors: Patil Rajvardhan , Gudivada And Venkat
Published: February 2024

Natural language Processing (NLP) has significantly transformed in the last decade, especially in the field of Language Modeling. Large Language Models (LLMs) have achieved SOTA performances on Natural Language Understanding (NLU) and Natural Language Generation (NLG) tasks by learning language representation in self-supervised ways. This paper provides a comprehensive survey to capture the progression of advances in Language Models. In this paper, we examine the different aspects of Language Models, which started with a few million parameters but have reached the size of a trillion in a very short time. We also look at how these LLMs transitioned from task-specific to task-independent to task-and-language-independent architectures. This paper extensively discusses different pre-training objectives, benchmarks, and transfer learning methods used in LLMs. It also examines different fine-tuning and In-Context learning techniques used in downstream tasks. It also explores how LLMs can perform well across many domains and datasets if sufficiently trained on a large and diverse dataset. Next, it discusses how, over time, the availability of cheap computational power and large datasets have improved LLM’s capabilities and raised new challenges. As part of our study, we also inspect LLMs from the lens of scalability to see how their performance is affected by the model’s depth, width, and data size. Lastly, we provide an empirical comparison of existing trends and techniques and a comprehensive analysis of where the field of LLM currently stand.
Integrated Management of Pathogens and Microbes on Cannabis sativa L. (Cannabis) under Greenhouse Conditions
Authors: Buirs Liam , PUNJA ZAMIR K.
Published: February 2024

The increased cultivation of high THC-containing Cannabis sativa L. (cannabis), particularly in greenhouses, has resulted in a greater incidence of diseases and molds that can negatively affect the growth and quality of the crop. Among them, the most important diseases are root rots (Fusarium and Pythium spp.), Botrytis bud rot (Botrytis cinerea), powdery mildew (Golovinomyces ambrosiae), cannabis stunt disease (caused by Hop latent viroid), and a range of microbes that reduce post-harvest quality. An integrated management approach to reduce the impact of these diseases/microbes requires combining different approaches that target the reproduction, spread and survival of the associated pathogens, many of which can occur on the same plant simultaneously. These approaches will be discussed in the context of developing an integrated plan to manage the important pathogens of greenhouse-grown cannabis at different stages of plant development. These stages include maintenance of stock plants, propagation through cuttings, vegetative growth of plants, and flowering. The cultivation of cannabis genotypes with tolerance or resistance to various pathogens is a very important approach, followed by the maintenance of pathogen-free stock plants. When combined with cultural approaches (sanitation, management of irrigation, and monitoring for diseases) and environmental approaches (greenhouse climate modification), a significant reduction in pathogen development and spread can be achieved. The use of preventive applications of microbial biological control agents and reduced risk biorational products can also reduce disease development at all stages of production in jurisdictions where they are registered for use. The combined use of promising strategies for integrated disease management on cannabis plants during greenhouse production will be reviewed. Future areas for research are identified.
A Multi-strategy Enhanced Dung Beetle Optimization Algorithm and Its Application in Engineering
Authors: Zhang Huiqiang , Zhang Ronghui
Published: February 2024

This paper introduces a novel multi-strategy enhanced dung beetle optimization (MSDBO) algorithm that is designed to address several issues identified in the standard dung beetle optimization algorithm. Specifically, the MSDBO aims to enhance convergence speed, reduce susceptibility to local optima, and increase search accuracy. By incorporating three strategies: tent chaotic mapping for population initialization, the golden sinusoidal strategy for position updating, and the Lévy flight strategy for balancing exploration and exploitation, the standard dung beetle optimization algorithm is enhanced. The MSDBO algorithm is evaluated using twelve benchmark test functions and compared against five state-of-the-art algorithms. The results consistently show that MSDBO exhibits faster convergence speeds and more accurate solutions than the other algorithms across most of the test functions. In addition, MSDBO is also applied to optimize the parameters of a valve plate, including the close angle, cross angle, triangle groove sizes, and wrap angle. The optimization outcomes reveal that MSDBO effectively minimizes pressure ripples in the piston chamber, resulting in reduced flow rate fluctuations and noise emission compared to the initial design. This study highlights the potential of the MSDBO algorithm in tackling complex nonlinear engineering optimization problems.
Temporal Synchronization of Nitrogen and Sulfur Fertilization: Impacts on Nutrient Uptake, Use Efficiency, Productivity, and Relationships with Other Micronutrients in Soybean
Authors: Khalili Azizullah , Ramesh Aketi , Sharma Mahaveer P
Published: February 2024

Nitrogen (N) and sulfur (S) are essential macro-elements crucial for the proper development, productivity, nutrient uptake, and the building blocks of protein biosynthesis. The plant's N-metabolism is also influenced by S, and its deficiency can lead to a decline in the consumption of N from fertilizers. The objective of this research was to assess the impacts Temporal N and S applications on the nutrient uptake, productivity, use efficiencies and micronutrients content status in soybean seeds. The field trial in randomized complete block design carried out, experiment comprised fourteen treatments with varying N and S quantities. N and S were applied through starter and temporal applications in different combinations. The findings indicated that temporal application of individually N and S fertilization as 25 kg ha-1 as starter and 25 kg ha-1 as temporal applications at R2 stage enhanced the highest nutrient uptake, seeds and stalks yields. The use efficiencies, as well as the Zinc (Zn) and iron (Fe) uptake by seeds, showed an increase with the temporal application of both nutrients compared to the control. Furthermore, soil Zn and Fe contents were also enhanced with the temporal applications of nitrogen and sulfur fertilization. As a result, it could be decided that the nitrogen and sulfur temporal applications not only enhanced nutrient uptake, productivity and use efficiencies but also improved the micronutrient uptake by soybean. Furthermore, this practice contributed to an improvement in soil Zn and Fe content.
Forest site and stand structure affecting the distribution of Emerald Ash Borer, Agrilus planipennis Fairmaire, 1888 (Coleoptera: Buprestidae) in Eastern Ukraine
Authors: Meshkova Valentyna , Borysenko Oleksandr , Kucheryavenko Tetiana , Vysotska Natalia , Skrylnyk Yuriy , Davydenko Kateryna , Holusa Jaroslav
Published: February 2024

Emerald ash borer (EAB), Agrilus planipennis, an invasive phloem-boring beetle, was detected in the Luhansk Region of Ukraine in 2019. In the following years, it expanded to a large part of the Kharkiv region and the parks of Kyiv. Previous research proved that the climate in Luhansk and neighboring regions is favorable for EAB, and the lack of a host plant (Fraxinus sp.) cannot prevent pest expansion in Ukraine. Considering the necessity to detect inhabited trees in time, our current research aimed to identify the most attractive EAB forest subcompartments considering forest site conditions and stand structure. MaxEnt model predicted the potential distribution of EAB with high accuracy (AUC = 0.842). The most significant five variables provided 82.9% to the model, particularly «Age of trees, years», «Area of forest subcompartment, ha», «Mean height of trees, m», «The proportion of Fraxinus excelsior in the stand composition, %», and «Hygrotope index (humidity level), point». A very high probability of EAB expansion in the Luhansk region (>90 %) is predicted at 20 % of the forest area with Fraxinus sp. in the stand composition. The probability of EAB spread above 30% is predicted for 75 % of such area. To improve the forecasting accuracy, it could be necessary to consider the data on road localization along which the pest can spread passively, as well as dominate wind speed.
CXCL1/CXCR2 and CCL5/CCR1/CCR5 Promote Radiation-Induced Reprogramming of Breast Non-cancer Stem Cells into Cancer Stem Cells and Predict Patient Clinical Outcome
Authors: Bailleul Justine , Brulé Mathilde , Bidan Nadège , Denoulet Marie , Mouttet Audouard Raphaelle , Cousin Sophie , Bouchaert Emmanuel , Benoit Jerome , Toillon Robert-Alain , Finetti Pascal , Birnbaum Daniel , Bertucci François , Adriaenssens Eric , Le Bourhis Xuefen , Lagadec Chann
Published: February 2024

Cancer stem cell (CSC) has paved the way to many fundamental and translational studies. Recent studies have highlighted differentiated breast cancer cells (non-CSCs) switching phenotype to CSCs in response to various stimuli, depicting the existence of cancer stem cell plasticity. Although strategies to reduce the phenotypic plasticity of non-CSCs into CSCs are likely to prevent treatment-resilient cancer cells driving recurrence, most phenotypic plasticity mechanisms involve Notch, Wnt or MAPK signaling pathways. In this study, breast cancer cells were irradiated to identify soluble reprogramming factors. Using conditioned medias, protein arrays analyses, flow cytometry and in cellulo/in vivo functional assays, we demonstrated, for the first time, that radiation-induced chemokine expression, especially CXCL1 and CCL5 and their receptors CXCR2, CCR1 and CCR5, stimulates reprogramming of breast non-CSCs into CSCs. Treatment of non-CSCs with recombinant CXCL1 and CCL5 is sufficient to induce cell reprogramming, while their inhibition can be used to prevent reprogramming and sensitize tumor to radiation. Moreover, analysis of gene expression profiles from 38 public merged databases demonstrated that combined over-expression of CXCL1/CXCR2, CCL5/CCR1 or CCL5/CCR5 has a poorer prognosis in patients treated with radiotherapy, suggesting a promising way for patient stratification, where individuals with elevated cytokine levels could benefit from radiotherapy in conjunction with cytokine inhibitors. Taken together, our findings provide a rationale to consider these axes as potential targets and predictive biomarkers in breast cancer patients.
Total Plate Count and pH of Layer Eggs Immersed in Leaf Aqueous Extract of Averrhoa bilimbi L.
Authors: Suharyanto Suharyanto , Marheny Titik , Kususiyah Kususiyah , Soetrisno Edi , Hajrawati Hajrawati
Published: February 2024

Layer eggs are low cost and highly nutritious, but they are perishable. Therefore, it is important applying preservation for prolong its shelf life. Preservation by using natural agent such as belimbing wuluh (Averrhoa bilimbi L) leaf (BWL) extract for food safety and consumer health is ratioable. This study aimed to evaluate the immersion of layer eggs in an aqueous extract of BWL on the pH value and total microbial eggs. The treatments employed were eggs without soaking (P0), eggs soaked in aquadest (P1), eggs soaked in solution of BWL leaf extract (SBWLE) 15% (P2), eggs soaked in SBWLE 30% (P3), and eggs soaked in SBWLE 45% (P4). Soaking was carried out for 24 hours with the proportion of egg: water SBWLE was 1:13. The extraction process was carried out by boiling the BWL for 10 minutes at a temperature of 85 ºC. The boiled water is filtered and the results were used for treatment. The data were analyzed by ANOVA and he significant effect (P <0.05) of treatments were tested by a post hoc Duncan's Multiple Range Test (DMRT). The results showed that eggs soaked in SBWLE had lower pH and total microbes than eggs without soaking and eggs soaked in aquadest. The higher concentration of SBWLE, the decreasing pH and total microbes in eggs. The conclusion was that the use of SBWLE 15-45% (w/v) was able to suppress egg microbial growth and prevent an increase in egg pH.
Keywords: Averhoa bilimbi, egg quality, microbes, pH
The Influence of Subjective Norms on Farmers' Behavior in Handling Goat Waste
Authors: Baba Syahdar , Hastang Hastang , Asnawi Aslina , Dagong Muhammad Andi Ihsan , Hendra Hendra , Indrawirawan Indrawirawan , Khasanah Aulia Uswa Noor , Risal Muhammad , Sohrah Sitti , Dariyatmo Iin Mulyawati
Published: February 2024

Waste treatment (WT) was one way to increase the income of small-scale goat farmers. Many factors influence breeders to adopt technology, including the subjective norm (SN) factor. This study aims to determine the effect of subjective norms (SN) consisting of the influence of informal leaders (IL), Family (F), extension (E) /Training Officer (TO), and peer groups (FG) or farmer neighbors (FN) on the behavior of farmers in feces waste treatment (WT). The research was carried out in West Sulawesi Province, precisely in Polman and the Majene Regencies, which were goat farming centers. The respondents were 50 in the Majene district and 100 in the Polman district. The determination of the sample was carried out randomly at the location of the goat breeding center (GBC). The research variable consisted of the behavior of farmers in adopting technology (AT), which consisted of five levels: feces disposed of (score 1), not processed and used alone (score 2), not processed and sold (score 3), processed and used alone (score 4). It was processed and sold (score 5). Independent variables consisted of subjective norms, including the Community Leader (CL) (X1), Family (F) (X2), Extension Workers (EW) or Technical Officers (X3), and Neighbors (N) or colleagues (C) influence (X4). The linear regression model was used to predict the F-test and t-test. The results showed that SN affects breeders’ behavior in processing goat livestock waste (GLW). The variable influence of EW, F, and N was a component of SN that influenced the behavior of breeders, to increase the adoption of WT technology, the role of EW must be increased in assisting farmers in adopting WT technology.
Keywords: Goat, subjective norm, adoption, extension officer, Family member
İngiltere’nin Osmanlı Devleti’nde Protestanlığı Yayma ve Filistin’de Yahudileri İskân Projesi [1837-1857]
Authors: DÖNMEZ Ahmet
Published: February 2024

İİngiltere, Fransa’nın Katolikleri ve Rusya’nın Ortodoksları himaye etmesi karşısında, Osmanlı Devleti’nde destekleyebileceği bir Protestan gruba ihtiyaç duyuyordu. Bu yüzden İngiliz elçileri ve konsolosları Protestanlaştırma faaliyetlerine doğrudan destek verdiler. Protestan misyonerler Ortodoksları, Katolikleri, Yahudileri ve hatta Müslümanları hedef aldı. Kudüs’te bir İngiliz konsolosluğu açılarak bu çalışmalara hız kazandırıldı. Aynı sırada misyoner cemiyetlerine üye kişiler konsolos atanarak hem Yahudilerin korunması ve hem de Avrupa’daki Yahudilerin bölgeye yerleştirilmesine yönelik bir proje yürütüldü. Misyoner cemiyetleriyle bağlantılı olan İngiltere Dışişleri Bakanı Lord Palmerston, Osmanlı’yı reformlarla güçlendirme politikasını uygularken bir yandan da bu projeleri yönetti. Kudüs’te bir Protestan kilisesi açılması konusu uzun süre Babıâli ve İngiliz elçiliği arasında çekişme konusu oldu. İngiltere ve Prusya ortak hareket ederek 1842 yılında Kudüs’e bir piskopos tayin ettiler ve kilise inşasına başladılar. İngiliz Elçisi Lord Stratford Canning’in baskıları sonucu 1845’te fermanla kiliseye izin verildi. 1856 yılında Islahat Fermanı ile Avrupa elçileri talep ettikleri diğer tüm ayrıcalıkları Osmanlı’dan aldılar. Bu sırada Yahudilere Filistin’de toprak satılması ve yerleşmelerine izin verilmesine yönelik baskılar artan bir şekilde devam etti.

Bu makalede, İngiltere’nin Kudüs’te konsolosluk ve Protestan Kilisesi açması, Filistin’de Yahudileri iskân politikası İngiliz ve Osmanlı arşiv kaynaklarına göre açıklanacaktır. Siyonizm’in temellerinin atıldığı bir süreçte, bir yandan Protestanlaştırma faaliyetlerinin yürütüldüğü ve giderek gayrimüslimlerin yönetiminde İngiliz müdahalesinin arttığı bir süreç ortaya koyulacaktır.
Systematics Literature Review: Mathematics Reasoning in Elementary School
Authors: Hs Atika Maulidina , Wiryanto Wiryanto , Mariana Neni
Published: February 2024

Based on data from PISA, it shows that students' mathematical abilities in Indonesia are still relatively low. Therefore, improving students' mathematical reasoning abilities is a way in order to cope with those problems. This research aims to analyze research related to the mathematical reasoning abilities of elementary school students in 2018-2022, considering that a literature review on this topic has never been carried out. The type of this research is a systematic literature review. Data was collected by documenting 20 selected articles in Sinta 1-6 journals and Scopus. The results of this research revealed that topics related to mathematical reasoning abilities in elementary schools have not been widely researched in the last five years. The majority of articles discuss the characteristics and the analysis of students' reasoning abilities mapping in a group. The most widely published Sinta 3 and Scopus articles with the most researched material are geometry. The frequent type of research carried out is quantitative. Suggestions for future research are to conduct further research related to the development of mathematical reasoning abilities in elementary schools, especially on fractions and algebra materia.
The Availability Of Worship Facilities And Infrastructure At Tangkahan Tourist Site Namo Sialang Village Batang Serangan Sub-District
Authors: Nadaya Khoir , Hasibuan Sahdin
Published: February 2024

The purpose of this study was to determine the descriptive condition of the availability of worship facilities and infrastructure at the Tangkahan tourist location, Namo Sialang Village, Batang Serangan District. The research method used is descriptive qualitative. The subjects in this study were the managers of Tangkahan tourist attractions, namely Mr. Ngarihkan Pasaribu as chairman and Mr. Kembaren as vice chairman, as well as 5 people around Namo Sialang Village, Batang Serangan Subdistrict. the data sources used were primary data sources, namely by conducting initial observations and then conducting interviews with the community and also using supporting secondary data. The results of the study are a. Based on the current condition of the area, including damaged road access, potholed pavement, lack of clean water and telecommunications networks, lack of electricity and lighting networks, lack of direction signs and some of them are damaged. no identity gate or welcome board, lack of security facilities, and lack of health facilities, it can be concluded that the availability of tourist facilities in the Tangkahan Nature Tourism area is very inadequate. b. One of the facilities and infrastructure related to sharia is the prayer room. In Tangkahan Nature Tourism, there are few prayer rooms for Muslims to pray, but there are some shortcomings. In Tangkahan Nature Tourism, there is an ablution place for Muslim visitors who want to clean themselves before carrying out their prayers.
Pembelajaran Matematika Menggunakan Media Akalimatika untuk Memperkuat Pemahaman Konsep Perkalian
Authors: Freida Fetty , Suryatin Suryatin , Al Fath Ayatullah Muhammadin
Published: February 2024

Penelitian ini bertujuan untuk: 1) mendeskripsikan pelaksanaan pembelajaran matematika menggunakan media akalimatika; 2) mengetahui apakah pembelajaran matematika menggunakan media akalimatika dapat memperkuat konsep perkalian siswa kelas II. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Teknik pengumpulan data menggunakan metode observasi, wawancara, dan dokumentasi. Uji keabsahan data menggunakan triangulasi sumber dan triangulasi teknik. Teknik analisis data meliputi reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan 1) pelaksanaan pembelajaran matematika menggunakan media akalimatika meliputi penyampaian petunjuk penggunaan, penjelasan konsep perkalian dan pemberian kesempatan siswa mempelajari konsep perkalian dengan menggunakan media. Proses belajar mengajar terjadi secara dua arah antara guru dan siswa; 2) berdasarkan indikator pemahaman konsep perkalian dari dokumentasi hasil tes dan wawancara sebanyak 75% siswa mampu menjawab pertanyaan sesuai dengan indikator pemahaman konsep perkalian tanpa bimbingan guru, sedangkan 25% siswa masih memerlukan bimbingan guru. Dengan demikian, penggunaan media akalimatika mampu memperkuat konsep perkalian siswa kelas II Sekolah Dasar.
Kesiapan Sekolah dalam Melaksanakan Pendidikan Inklusif di Sekolah Dasar Inklusi Kabupaten Pacitan Wilayah Timur
Authors: Aminulloh Alfan Saifut , Purnamasari Mega Isvandiana , Erviana Lina
Published: February 2024

Penelitian ini bertujuan untuk 1) mengetahui kesiapan fisik dan sarana prasarana dalam proses pelaksanaan  pendidikan  inklusi, 2) mengetahui  kesiapan sumber daya manusia dalam proses pelaksanaan pendidikan inklusi, 3) mengetahui hambatan dalam penyelenggaraan pendidikan Inklusi. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa 1) persentase kesiapan sarana dan prasarana mencapai 62,5%, mengindikasikan bahwa kedua sekolah siap melaksanakan pendidikan inklusi. 2) kesiapan sumber daya manusia juga terpenuhi dengan adanya lebih dari 2 Guru Pendamping Khusus yang terlatih di kedua sekolah, 3) hambatan yang  dihadapi dalam  penyelenggaraan  pendidikan  inklusif  meliputi kurangnya beberapa fasilitas pendukung seperti media pembelajaran  dan  belum adanya aksesbilitas bagi anak berkebutuhan khusus serta kurangnya atensi dari orangtua siswa.
Plan de negocios para el servicio de hospedaje para mascotas en Lima metropolitana
Authors:   , Guardia Allccarima William David , Medina Huisa Lucy Ariana , Nolasco Urrutia Marysol Aurora , Moran del Rio Carlos Alberto , Cabezas Ramos Mayra Alejandra
Published: February 2024

En resumen, nuestra ventaja competitiva radica en la atención personalizada y el compromiso con el bienestar de cada mascota que se hospeda en nuestro hotel para perros. El acceso a cámaras web y la atención personalizada a las necesidades alimenticias son solo algunos ejemplos de cómo nos destacamos de otros hoteles para perros. En nuestro hotel, los propietarios de mascotas pueden estar seguros de que sus perros están recibiendo la mejor atención posible mientras están instalados con nosotros.
Actitud investigativa en estudiantes de pregrado de Estomatología de una Universidad privada de Lima
Authors:   , Quintana Solorzano Brenda
Published: February 2024

Introducción: La investigación en la salud facilita un correcto diagnóstico y tratamiento de los pacientes que resulta sustancial para el avance de la educación en ciencias de la salud. Objetivo: Determinar el nivel de actitud investigativa en los estudiantes de pregrado de estomatología de una universidad privada de Lima. Materiales y métodos: Estudio observacional con una muestra de 142 estudiantes de cuarto a décimo ciclo. Se utilizó un cuestionario virtual basado en 34 preguntas sobre la actitud investigativa con 3 dimensiones (afectiva, cognoscitiva y conductual) y respuestas tipo Likert desde muy en desacuerdo hasta muy de acuerdo categorizado en 5 niveles (muy bajo, bajo, neutro, alto y muy alto). También se recolectó datos de edad, sexo, ciclo académico y tipo de ingreso. El instrumento fue sometido a validación por tres expertos (V Aiken=99,8 %). Las pruebas estadísticas inferenciales utilizadas fueron correlación de Spearman, U de Mann-Whitney y Chi-cuadrado a un P valor de 0,05. Resultados: Se obtuvo un total de 159 encuestados. La edad media fue de 23,80 ± 23,22 con predominio de participantes mujeres (71,3%). Hubo un predominio del nivel alto (62,3 %) donde ningún estudiante presentó un nivel muy bajo o bajo. La edad, sexo, ciclo académico y tipo de ingreso no tuvieron una relación estadísticamente significativa con el nivel de actitud investigativa. Conclusiones: Los estudiantes de odontología tuvieron un nivel de actitud investigativa alta predominando en la dimensión cognoscitiva. Sin embargo, es necesario realizar un estudio con respecto a las barreras a la investigación que pudieran tener los estudiantes para obtener una información más detallada.
Asociación entre el grado de sobrecarga de los cuidadores y técnicas de Enfermería con los síntomas relacionados a salud mental en adultos mayores en una residencia geriátrica
Authors:   , Cardenas Retamozo Fernando Humberto , Villarreal Velis Adolfo Nicolas
Published: February 2024

El cuidado del adulto mayor requiere una experiencia de habilidades establecidas para una correcta atención, que va más allá de realizar actividades del hogar, esto resulta en cambios que alteran la vida diaria de los cuidadores, así como a nivel familiar. Nuestro objetivo fue determinar en una población de adultos mayores con demencia, si el antecedente de problemas de salud mental en adultos mayores se asociaba al estrés del cuidador. Se realizó un estudio observacional, analítico, de corte transversal. El universo de estudio lo constituyeron 60 participantes cuidadores en el periodo 2022 – 2023. Se utilizó la escala de Zarit para determinar el nivel de estrés de los cuidadores. Para las variables numéricas se calculó el promedio y la desviación estándar, para las variables categóricas se calculó la frecuencia y el porcentaje. Para el análisis bivariado se utilizó la prueba exacta de Fisher para variables categóricas y la prueba T de Student para variables numéricas. Los resultados obtenidos mostraron que, en el caso de los cuidadores con estrés, la frecuencia de antecedente de depresión en pacientes fue de 69.23% (N=27) y las diferencias fueron estadísticamente significativas. Además, se encontró que la frecuencia de estrés del cuidador fue mayor mientras más severa fuera la demencia, así en los pacientes con demencia en estadio leve la frecuencia de estrés del cuidador fue de 10.26% mientras que los pacientes con demencia estadio severo fue de 69.23% (N=27). Se encontró que, en los adultos mayores con demencia, la severidad de la misma y el antecedente de depresión se asocian con mayores probabilidades de estrés del cuidador. Por lo que se sugiere realizar un tamizaje de estrés del cuidador para evitar complicaciones de este síndrome geriátrico.
ANATOMICAL PATHOLOGY AND HISTOLOGICAL OF SMALL INTESTINAL ORGANS IN BROILER INFECTED WITH ASCARIDIA GALLI
Authors: Rahmawati Indra , Wardhani Lailia Dwi Kusuma , Palgunadi Bagus Uda
Published: February 2024

Infection with Ascaridia galli still attacks poultry farms, especially chickens in Indonesia. This study aims to determine the causes of changes in anatomy pathological and histology in small intestine of broiler. The study was taken from Alif which had clinical symptoms of weakness and anorexia on July 5, 2022 in Gresik Jawa Timur. The results of anatomical pathology and histological examination showed changes in the duodenum and jejunum organs showing hemorrhagic and inflammatory cell infiltration. The results of parasite examination found A.galli worms in the lumen of the small intestine and A.galli worm eggs from feces. In this study, clinical symptoms and anatomy pathological and histology changes of the small intestine in the broiler were caused by infection with A. galli worms.
Di-n-butyl phthalate regulates insulin sensitivity in human skeletal muscle cell line through the PI3K-AKT-GLUT4 signaling pathway
Authors: Shan Dan , Chen Yan , Zhou Kunyan
Published: February 2024

Background: Dibutyl phthalate (DBP) exposure is a serious environmental problem causing human health threats in China and is closely related to the development of insulin resistance, but its mechanism is unclear. Skeletal muscle tissue is one of the important tissues involved in insulin resistance, and its molecular mechanisms may involve various links of the insulin signaling cascade in muscle cells.
Methods: In this study, the mRNA and protein expression of the above signaling gene were detected and quantified by Real-time quantitative PCR (RT-qPCR) and Western blotting in human skeletal muscle cell line HSkMC cells, and the InsR-IRS1-PI3K-AKT-GLUT4 signaling pathway as the entry point.
Results: The mRNA levels of InsR, IRS-1, PI3K, AKT2, and GLUT4 were reduced after DBP treatment compared with control cells.DBP and PI3K inhibitor BKMl20 or DBP transfected with PTEN overexpression lentivirus further reduced the mRNA expression levels of PI3K, AKT2, and GLUT4. In addition, DBP treatment also reduced the expression of InsR, IRS-1, PI3K, AKT2, and GLUT4 and the phosphorylation of AKT2, but both DBP with BKMl20 or DBP was transfected with PTEN overexpression.
Conclusions: Based on the above results, this study is the first to find a possible molecular mechanism of DBP in skeletal muscle insulin resistance through regulating the PI3K-dependent insulin signaling pathway of skeletal muscle cells, providing a rationale for the pathophysiological changes in the initiation and progression of insulin resistance caused by DBP.
Should pain be allowed or avoided during shoulder rehabilitation exercises for patients with chronic rotator cuff tendinopathy? Study protocol for a randomized controlled trial – the PASE trial.
Authors: Kjær Birgitte Hougs , Cools Ann M. , Johannsen Finn E. , Trostrup Jeanette , Bieler Theresa , Siersma Volkert , Magnusson S. Peter
Published: February 2024

Background: Rotator cuff (RC) tendinopathy is the most reported shoulder disorder in the general population with highest prevalence in overhead athletes and adult working-age population. A growing body of evidence support exercise therapy as an effective intervention, but to date there are no prospective randomized controlled trials addressing pain as an intervention variable.Methods: A single-site, prospective, pragmatic, assessor-blinded randomized controlled superiority trial. Eighty-four patients aged 18-55 years with chronic (symptom duration over 3 months) RC tendinopathy are randomized 1:1 to receive shoulder exercise during which pain is either allowed or avoided. The intervention period lasts 26 weeks. During that period participants in both groups are offered 8 individual on-site sessions with an assigned sports physiotherapist. Participants perform home exercises and are provided with a pain and exercise logbook and asked to report completed home-based exercise sessions and reasons for not completing sessions (pain or other reasons). Patients are also asked to report load and the number of sets and repetitions per sets for each exercise session. The logbooks are collected continuously throughout the intervention period. The primary and secondary outcomes are obtained at baseline, 6 weeks, 26 weeks, and 1 year after baseline. The primary outcome is patient reported pain and disability using the Shoulder PAin and Disability Index (SPADI). Secondary outcomes are patient reported pain and disability using Disability Arm Shoulder and Hand shortform (Quick DASH), and shoulder pain using Numeric Pain Rating Scale. Objective outcomes are shoulder range of motion, isometric shoulder muscle strength, pain sensitivity, working ability and structural changes in the supraspinatus tendon and muscle using ultrasound.Discussion: The results of this study will contribute knowledge about the treatment strategies for patients with RC tendinopathy and help physiotherapists in clinical decision-making. This is the first randomized controlled trial comparing the effects of allowing pain versus avoiding pain during shoulder exercises in patients with chronic RC tendinopathy. If tolerating pain during and after exercise proves to be effective, it will potentially expand our understanding of 'exercising into pain' for this patient group, as there is currently no consensus.Trial registration: ClinicalTrials.gov NCT05124769. Registered on August 11, 2021. URL https://clinicaltrials.gov/search?cond=NCT05124769
HAR-ViT:A human activity recognition method based on ViT
Authors: Han Huiyan , Zeng Hongwei , Kuang Liqun , Han Xie , Xue Hongxin
Published: February 2024

Human activity recognition has a wide range of applications in various fields, such as video surveillance, virtual reality, and human-computer intelligent interaction. It has emerged as a significant research area in computer vision. Key algorithms utilized include P-LSTM (partial sensing LSTM), ST-GCN (Spatiotemporal graph convolutional networks), and 2s-AGCN (two-flow adaptive graph convolutional networks). Despite the remarkable achievements made by these algorithms, there are still some challenges to address, including unsatisfactory recognition accuracy, convergence difficulties, and limited generalization ability. To tackle these issues, this paper proposes HAR-ViT - a human activity recognition method based on Vision Transformer architecture. The enhanced AGCN (eAGCN) map filter is employed to assign weights to human skeleton data, highlighting key nodes and promoting model convergence. The position encoder module captures precise timing information while the transformer encoder efficiently compresses sequence data features to enhance calculation speed. Human activity recognition is accomplished through multi-layer perceptron (MLP) classifiers. Experimental results demonstrate that the proposed method achieves an accuracy of 91.06% for cross-subject and 96.73% for cross-view human behavior recognition on the NTU60 dataset respectively; similarly achieving accuracies of 87.61% and 89.02% on the NTU120 dataset for the same task respectively compared to state-of-the-art algorithms with an improved accuracy of approximately 1%, while reducing total parameter count by 57.24%.
Effect of Ce on the acidity of LaMnO3 / Fe2O3 catalyst in NH3-SCR at low temperature
Authors: hao wencong , luo siyi , ren dongdong , xu yongchao , zuo zongliang , sha haohan
Published: February 2024

A series of La1 − xCexMnO3/Fe2O3 catalysts were prepared by citric acid method, and their catalytic denitration efficiency and water and sulfur resistance were tested., XRD, BET, H2-TPR, NH3-TPD, XRF, TG and In situ DRIFTS are used to characterize the crystal structure redox properties of the catalysts. The results show that Fe2O3 catalyst loading LaMnO3 can significantly enhance the catalytic denitrification ability of the catalyst at low and medium temperatures. When the doping amount of LaMnO3 is 40%, the catalyst effect is the best, and the maximum efficiency is 94% at 240℃. The optimal temperature activity window is expanded by 30.8% compared with Fe2O3 catalyst at 240℃ to 330℃. The flue gas temperature corresponding to the optimal catalytic denitration efficiency is reduced by 30℃. Ce doping can improve the distribution of active substances on the catalyst surface and further improve the catalytic denitration efficiency at low temperature. La0.6Ce0.4MnO3/Fe2O3 has the highest catalytic denitrification efficiency, reaching the highest efficiency of 96% at 240℃, which is about 4% higher than that of undoped catalyst. In addition, Ce doping significantly weakened the formation of sulfate on the catalyst surface, and La0.6Ce0.4MnO3/Fe2O3 catalyst showed excellent sulfur resistance and water resistance.
Whole Genome Sequencing and Analysis of Benzo(a)pyrene Degrading Bacteria Bacillus cereus ZR72-1
Authors: tuerxun Dilibaier , zhang rui , qin yanan , jin aofei , tan lirong , yang zhuonan , duo zhixian
Published: February 2024

Background
Benzo (a) pyrene produced by food during high-temperature process enters the body through ingestion, which causes food safety issues to the human body. In order to alleviate the harm of foodborne benzo (a) pyrene to human health, a strain that can degrade benzo (a) pyrene was screened from Kefir, a traditional fermented product in Xinjiang.
Results
Bacillus cereus ZR72-1 is a Gram-positive bacteria sourced from XinJiang traditional fermented product Kefir, under Benzo(a)pyrene stress conditions, there was 69.39% degradation rate of 20 mg/L Benzo(a)pyrene by strain ZR72-1 after incubation for 72 h. The whole genome of ZR72-1 sequenced using PacBio sequencing technology was reported in this study. The genome size was 5754801 bp and a GC content was 35.24%, a total of 5719 coding genes were predicted bioinformatically. Through functional database annotation, it was found that the strain has a total of 219 genes involved in the transportation and metabolism of hydrocarbons, a total of 9 metabolic pathways related to the degradation and metabolism of exogenous substances, and a total of 67 coding genes.
Conclusions
According to the KEGG database annotation results, a key enzyme related to Benzo(a)pyrene degradation, catechol 2,3-dioxygenase, was detected in the genome data of Bacillus cereus ZR72-1, encoding genes dmpB and xylE, respectively; There are also monooxygenases and dehydrogenases. Therefore, it can be inferred that this strain mainly degrades Benzo(a)pyrene through Benzoate metabolic.