bluuebunny/crossref_metadata_2025 huggingface dataset:
3D printer emissions elicit filament-specific and dose-dependent metabolic and genotoxic effects in human airway epithelial cells
Authors: Barnett LMA , Zhang Q. , Sharma S. , Alqahtani S. , Shannahan J. , Black M. , Wright C.
Published: July 2024

Three-dimensional (3D) printers have become popular educational tools in secondary and post-secondary STEM curriculum; however, concerns have emerged regarding inhalation exposures and associated health risks. Current evidence suggests that filament materials and site conditions may cause differences in the chemical profiles and toxicological properties of 3D printer emissions; however, few studies have evaluated exposures directly in the classroom. In this study, we monitored and sampled particulate matter (PM) emitted from acrylonitrile-butadiene-styrene (ABS) and polylactic acid (PLA) filaments during a 3-hour 3D printing session in a high school classroom using aerosol monitoring instrumentation and collection media. To evaluate potential inhalation risks, Multiple Path Particle Dosimetry (MPPD) modeling was used to estimate inhaled doses and calculate in vitro concentrations based on the observed aerosol data and specific lung and breathing characteristics. Dynamic light scattering was used to evaluate the hydrodynamic diameter, zeta potential, and polydispersity index (PDI) of extracted PM emissions dispersed in cell culture media. Small airway epithelial cells (SAEC) were employed to determine cellular viability, genotoxic, inflammatory, and metabolic responses to each emission exposure using MTS, ELISA, and high-performance liquid chromatography-mass spectrometry (HPLC-MS), respectively. Aerosol monitoring data revealed that emissions from ABS and PLA filaments generated similar PM concentrations within the ultrafine and fine ranges. However, DLS analysis showed differences in the physicochemical properties of ABS and PLA PM, where the hydrodynamic diameter of PLA PM was greater than ABS PM, which may have influenced particle deposition rates and cellular outcomes. While exposure to both ABS and PLA PM reduced cell viability and induced MDM2, an indicator of genomic instability, PLA PM alone increased gamma-H2AX, a marker of double-stranded DNA breaks. ABS and PLA emissions also increased the release of pro-inflammatory cytokines, although this did not reach significance. Furthermore, metabolic profiling via high performance liquid chromatography-mass spectrometry (HPLC-MS) and subsequent pathway analysis revealed filament and dose dependent cellular metabolic alterations. Notably, our metabolomic analysis also revealed key metabolites and pathways implicated in PM-induced oxidative stress, DNA damage, and respiratory disease that were perturbed across both tested doses for a given filament. Taken together, these findings suggest that use of ABS and PLA filaments in 3D printers within school settings may potentially contribute to adverse respiratory responses especially in vulnerable populations.
First Step to empowering change: enhancing self-efficacy, energy management, and physical activity in patients with sleep apnea
Authors: Johannesen Gitte , Damlund Anders Ravnholt Schüsler , Grundtvig Vinter Sofie , Spuur Helle Skadborg , Sarkez-Knudsen Mathias , Thomsen Thora Grothe
Published: July 2024

Introduction

Fatigue often leads to a sedentary lifestyle, negatively impacting health, mortality, and quality of life. Engaging in physical activity can be challenging for individuals experiencing fatigue, particularly those with sleep apnea. This study's objective was to assess the “First Step” concepts’ usability in constructing and implementing different interventions through qualitative data. The intervention targets patients with sleep apnea, focusing on individualized energy distribution and meaningful engagement in physical activity.

Methods

Two programs were developed based on the First Step concept, a rehabilitation program and a patient education program. Initially, 13 patients were recruited, split between the groups, with two dropping out. Primarily evaluated through qualitative data, patients in both groups attended group interviews. For one of the programs supplementary quantitative data were collected through the 6-min walk test (6MWT), Sit-to-Stand test, and Canadian Occupational Performance Measure (COPM). Patients in the rehabilitation program also monitored daily step counts using activity trackers.

Results

Patients found the energy management education enlightening, enabling them to make conscious changes in their daily lives. They reported the program's positive reception, with social interaction playing a crucial role in its success. Of the six patients who completed the rehabilitation program, significant improvements in 6MWT scores were observed, indicating enhanced walking endurance. While no changes were seen in the Sit-to-Stand test, COPM results showed notable improvements in performance and satisfaction with chosen activities.

Discussion

The incorporation of the First Step concept empowered patients with sleep apnea to manage fatigue, conserve energy, engage in meaningful activities, and improve their wellbeing. Merging occupational therapy and physiotherapy interventions effectively addressed daily challenges while promoting physical activity. Adaptations to the program, guided by patient feedback, suggest a preference for longer, more personalized sessions. This approach offers a promising pathway to improving quality of life for individuals with chronic conditions.

Conclusion

Our study highlights the usability of the First Step concept, integrating occupational therapy and physiotherapy, to address challenges in individuals with sleep apnea. The tailored, multidisciplinary intervention prioritizes meaningful activities, focuses on energy distribution and physical exercise, yielding improved satisfaction and performance. Further research is warranted to enhance this salutogenic approach for chronic conditions.
Quantum technologies with Rydberg atoms
Authors: Barik Shovan Kanti , Thakur Aishwarya , Jindal Yashica , S Silpa B. , Roy Sanjukta
Published: July 2024

Rydberg atoms have highly controllable exotic properties such as strong inter-atomic interaction, high polarizability, and long lifetimes which enabled unprecedented progress in Rydberg atom-based quantum Technologies. We present a brief review of recent progress in the development of quantum technologies using Rydberg atoms. We highlight the recent advances in the various regimes of quantum technologies such as quantum Information processing, quantum sensing, quantum simulation of many-body physics and single-photon sources for quantum communications.
A literature review of biomarkers used for diagnosis of relative energy deficiency in sport
Authors: Dvořáková Kristýna , Paludo Ana Carolina , Wagner Adam , Puda Dominik , Gimunová Marta , Kumstát Michal
Published: July 2024

Introduction

The review aims to summarize the markers used in diagnosing relative energy deficiency in sport (REDs) and compare them with the REDs CAT2 score.

Methods

A systematic search was performed in the PubMed, Web of Science, and SPORTDiscus databases during April 2023. The descriptors used were “athlete” AND “REDs,” along with respective entry terms. The selection process followed the PRISMA 2020 recommendations, identifying 593 records, from which 13 studies were ultimately selected. Seventy-nine markers were identified and categorized into six groups: bone mineral density (BMD), metabolic resting rate, blood biomarkers, anthropometrics, nutritional intake, and performance parameters. The most frequently utilized biomarkers included BMD, anthropometric parameters (e.g., body mass index, body mass, and fat mass), and the triiodothyronine (T3) concentration.

Results

According to the REDs CAT2 pointed indicators, the biomarkers varied among the studies, while 7 out of the 13 included studies achieved a ≥60% agreement rate with this tool. The prevalence of low energy availability, an etiological factor in the development of REDs, was detected in 4 out of 13 studies, with an average of 39.5%.

Conclusion

In conclusion, this review highlights the most commonly used markers in diagnosing REDs, such as BMD, anthropometric parameters, and T3 hormone concentration. Due to the current inconsistencies, standardizing diagnostic methodologies is crucial for future research. By focusing on widely used markers, this review aids future research planning and result interpretation and points out the ongoing need for methodological consistency in evolving diagnostic tools.

Systematic Review Registration

https://www.crd.york.ac.uk/, PROSPERO (CRD42022320007).
Effects of dietary supplementation of Zn-nanoparticles on the growth performance and nutritional quality of Asian catfish, Clarias batrachus
Authors: Jewel Abu Sayed , Haque Ayenuddin , Akter Nasrin , Akter Sumaiya , Satter Abdus , Sarker Pallab Kumer , Marshall David J. , Paray Bilal Ahamad , Hossain M. Belal
Published: July 2024

Nano-sized Zn particles are recognized for its ability to elevate fish health and well-being, enhancing antimicrobial and antioxidant capacities and reinforcing the immune system. In the present study we explored the effects of Zn-NPs supplementation on augmenting the growth performance and nutritional indicators and physiological aspects of the catfish, Clarias batrachus. Zn-NPs were prepared by heating the mixture of [Zn(CH3COO)2.2H2O], ethylene glycol and polymer surfactant (PVP) at 70°C for 45 min using an oil bath heater. The resultant solution was centrifuged at 6000 rpm on a heated plate at 70°C until the precipitation of Zn-NPs was achieved. Crystal structure, growth mechanisms and shapes of Zn-NPs were characterized by the atomic force microscopy. Produced Zn-NPs was characterized by spectrophotometer and the zeta potential and mean size was recorded as −32.5 ± 1.0 mV and 14.7 ± 2.5 nm, respectively. The experiment comprised six distinct test diets, categorized by the incorporation of Zn-NPs at levels of 0, 10, 20, 30, 40, and 50 mg/kg into the feed where the initial diet was employed as a control group, devoid of any Zn-NPs supplementation. Three glass aquariums were employed for each diet. In each aquarium, 12 fish with an initial mean weight of 5.23 ± 0.06 g were stocked. The fish underwent experimental feeding for 60 days, with the feed amount set at 3% of their body weight. After the experimental period, growth performance (weight gain, length gain, average daily gain, specific growth rate, thermal growth co-efficient, condition factor and survival rate), nutritional indices (feed conversion ratio, protein efficiency ratio, annual net protein utilization), proximate composition of muscle (protein, lipid, carbohydrate, ash and moisture), hematological parameters (RBC, WBC, hemoglobin, hematocrit, MCV, MCH, MCHC, total protein, albumin and globulin), serum lipid and enzymatic parameters (total cholesterol, HDL, LDL, triglycerides, ALP, AST, ALT, amylase, lipase and protease), and bioaccumulation of Zn in different organs of fish were estimated following standard methods. Growth analysis revealed that C. batrachus fed with Zn-NPs at 40 mg/kg of feed had significantly (p < 0.05) improved growth performance (WG = 18.87 ± 0.91 g, SGR = 2.52 ± 0.06% g/day, TGC = 1.09 ± 0.05 and CF = 1.47 ± 0.12), nutritional indices (FCR = 1.35 ± 0.06, PER = 2.24 ± 0.10 and ANPU = 41.46 ± 2.56%), hematological parameters, and enzymatic activity compared to control and other groups. The optimal dietary supplementation of Zn-NPs for final weight, weight gain and specific growth rate of C. batrachus was estimated to be ranged between 30.4 and 30.5 mg/kg per diet, respectively.
Quinoa protein hydrolysates improved the qualities and volatiles of yogurt fermented by Lactobacillus plantarum
Authors: Chen Ao-Xin , Meng Fan-Bing , Li Jia-Jia , Chen Xiao-Chun , Li Yun-Cheng , Jiang Li-Shi
Published: July 2024

Lactobacillus plantarum is a functional probiotic and could be used in yogurt fermentation to improve the function and flavor. However, L. plantarum has relatively poor acid resistance, and cell viability gradually decreases as pH decreases during yogurt fermentation. Therefore, exploring suitable strategies to promote the fermentation of L. plantarum for yogurt processing is important. In the present study, the effects of quinoa protein hydrolysates (QPHs) on the qualities and volatiles of yogurt fermented by L. plantarum were investigated. QPH addition significantly promoted bacterial growth and organic acids production, subsequently improved the water-holding capacity and viscosity of yogurt. QPH addition also increased the overall antioxidant capacity of yogurt, but the DPPH radical-scavenging ability of 1% QPH-supplemented yogurt was significantly greater than that of 2% QPH-supplemented yogurt. Additionally, QPHs promoted the metabolism of L. plantarum and further promoted the production of volatile flavor compounds. Fifty-two volatile compounds (mainly acids, esters, and ketones) were detected in 2% QPH-supplemented yogurt, which was 1.86-fold greater than the number detected in the control samples. Some aroma components, such as nonanoic acid and maltol, were significantly increased, but undesirable volatiles, such as decanal, were decreased. QPH composition analysis indicated that 60.79% of the peptides contained hydrophobic amino acids at the N-terminus or the C-terminus, which may explain QPHs’ strong antioxidant properties.
Evaluation of canine tympanic membrane integrity using positive contrast computed tomography canalography
Authors: Alves-Nores V. , Plested M. J. , Rubial R. , Salgüero R.
Published: July 2024

Introduction

The assessment of the integrity of the tympanic membrane (TM) can be a diagnostic challenge in patients with otitis externa and/or otitis media (OM) under an otoscopic examination. In computed tomography (CT), the TM is not always visualized. However, a positive contrast canalography using conventional radiography has been previously described to evaluate the TM integrity.

Objective

This single-center study aimed to describe the positive contrast canalography technique in CT and its usefulness in identifying TM integrity in 11 dogs.

Methods

Dogs with clinical signs of ear disease underwent CT canalography following a systematic protocol.

Result

The presence of contrast medium and contrast homogeneity within the tympanic cavity was assessed, confirming TM rupture when contrast medium was present in the tympanic cavity. CT canalography was performed in 16 ears, and in 7 of the 16 ears (44%), there was a contrast in the tympanic cavity, confirming TM rupture (positive CT canalography result). In two of the seven cases (29%), rupture of the TM was identified in both otoscopic and CT canalography. In the remaining five of the seven (71%) positive CT canalography results, tympanic membrane rupture was identified only by CT canalography.

Discussion

In conclusion, a positive contrast CT canalography is a complementary and safe technique to assess TM integrity, with a potentially higher sensitivity than otoscopic examination for the diagnosis of TM rupture in dogs.
Microencapsulation technology for delivery of enzymes in ruminant feed
Authors: Almassri Nada , Trujillo Francisco J. , Terefe Netsanet Shiferaw
Published: July 2024

The ruminant digestive system is uniquely designed to make efficient use of high-fibre feed, including forages. Between 40 to 100% of the ruminant diet consists of forages which are high in fibre and up to 70% of this may remain undigested in the ruminant gut, with substantial impact on feed utilisation rate and productivity and the economic and environmental sustainability of livestock production systems. In ruminants, feed costs can make up to 70% of the overall cost of producing an animal product. Increasing feed utilisation efficiency, i.e., more production with less feed lowers feeding costs and improves livestock economic viability. Strategies for improving nutrient utilisation in animal feed has been investigated over the years. Incorporation of fibre digesting enzymes in the feed to facilitate the digestion of the residual fibre in hind gut is one of the proposed strategies. However, delivering such enzymes to the hind gut in active state is challenging due to the unfavourable biochemical environment (pH, microbial proteases) of ruminant’s gastrointestinal tract. This review discusses the potential application of microencapsulation for protected and targeted delivery of enzymes into the hind gut of ruminants.
Real-Time Tracking and Detection of Cervical Cancer Precursor Cells: Leveraging SIFT Descriptors in Mobile Video Sequences for Enhanced Early Diagnosis
Authors: Alcaraz-Chavez Jesus Eduardo , Téllez-Anguiano Adriana del Carmen , Olivares-Rojas Juan Carlos , Martínez-Parrales Ricardo
Published: July 2024

Cervical cancer ranks among the leading causes of mortality in women worldwide, underscoring the critical need for early detection to ensure patient survival. While the Pap smear test is widely used, its effectiveness is hampered by the inherent subjectivity of cytological analysis, impacting its sensitivity and specificity. This study introduces an innovative methodology for detecting and tracking precursor cervical cancer cells using SIFT descriptors in video sequences captured with mobile devices. More than one hundred digital images were analyzed from Papanicolaou smears provided by the State Public Health Laboratory of Michoacán, Mexico, along with over 1800 unique examples of cervical cancer precursor cells. SIFT descriptors enabled real-time correspondence of precursor cells, yielding results demonstrating 98.34% accuracy, 98.3% precision, 98.2% recovery rate, and an F-measure of 98.05%. These methods were meticulously optimized for real-time analysis, showcasing significant potential to enhance the accuracy and efficiency of the Pap smear test in early cervical cancer detection.
Role of Partial Flexibility on Flow Evolution and Aerodynamic Power Efficiency over a Turbine Blade Airfoil
Authors: Koca Kemal , Genç Mustafa Serdar
Published: July 2024

In this study, the aerodynamic performance of a cambered wind turbine airfoil with a partially flexible membrane material on its suction surface was examined experimentally across various angles of attack and Reynolds numbers. It encompassed physical explanation at the pre/post-stall regions. The results of particle image velocimetry revealed that the laminar separation bubble was diminished or even suppressed when a local flexible membrane material was employed on the suction surface of the wind turbine blade close to the leading edge. The results of the deformation measurement indicated that the membrane had a range of flow modes. This showed that the distribution of aerodynamic fluctuations due to the presence of LSB-induced vortices was reduced. This also led to a narrower wake region occurring. Aerodynamic performance improved and aerodynamic vibration significantly lowered, particularly at the post-stall zone, according to the results of the aerodynamic force measurement. In addition to the lift force, the drag force was enormously reduced, corroborating and matching well with the results of PIV and deformation measurements. Consequently, significant benefits for a turbine blade were notably observed, including aerodynamic performance enhancement, increased aerodynamic power efficiency, and reduced aerodynamic vibration.
The Biophilic School: A Critical Synthesis of Evidence-Based Systematic Literature Reviews
Authors: Fisher Kenneth
Published: July 2024

Biophilic design emphasises human connections to nature to enhance health and well-being. In health and medical environments, the biophilic design hypothesis suggests improved healing and health outcomes when patients have a connection to nature. Emerging evidence indicates that if teachers and students experience a greater sense of health and well-being in the campus environment, they are likely to have better teaching and learning outcomes. To understand this at a deep level, a critical synthesis and analysis of some fifty systematic reviews outlines the significant emerging body of evidence in support of this approach. Systematic reviews are a fundamental basis for new research to be framed in the context of existing research findings within the evidence-based research methodology. Key outcomes of this critical synthesis review are that there is compelling evidence of some 70 health and well-being factors being improved though biophilic design. Also, organising an agreed taxonomy of biophilic design and health and well-being elements at a granular level would assist in simplifying and compiling the evidence of the benefits of such an approach to inform school funding, planning, design and operations authorities.
Temporal and Spatial Variation Characteristics of the Ecosystem in the Inner Mongolia Section of the Yellow River Basin
Authors: Yang Junjie , Jia Laigen , Hao Jun , Luo Qiancheng , Chi Wenfeng , Wang Yuetian , Zheng He , Yuan Ruiqiang , Na Ya
Published: July 2024

As one of the most vital ecological regions in China, the well-being of the Inner Mongolia section of the Yellow River Basin directly hinges upon comprehending the variations in its ecosystem. The current research puts emphasis on the analysis of single-factor ecological indicators within the Mongolian section of the Yellow River and lacks summarization and analysis regarding the overall state of the ecosystem within the Mongolian section of the Yellow River. This study, using methods such as remote sensing interpretation and model simulation, combined with ground surveys, analyzes the macrostructure, quality status, service functions, and driving factors of the ecosystem in the Inner Mongolia section of the Yellow River Basin from 2000 to 2020. The results indicate that (1) in 2020, the ecosystem structure in the Inner Mongolia section of the Yellow River Basin was predominantly composed of forest, grassland, and other types of systems. (2) From 2000 to 2020, the Normalized Difference Vegetation Index (NDVI), Fractional Vegetation Cover (FVC), and net primary productivity (NPP) all showed increasing trends in the Inner Mongolia section of the Yellow River Basin, with NPP showing a slightly greater increase compared to the NDVI and FVC. (3) Over the past two decades, the overall rate of decrease in the wind erosion modulus per unit area was 1.675 t hm−2. (4) An analysis of the drivers of ecosystem changes revealed that while climate change has exerted an influence, human activities have likewise had a substantial effect on the ecosystem over the past 20 years. This study contributes to a comprehensive understanding of the current status and changes in the ecosystem, providing a decision-making basis for subsequent ecological protection and management projects.
Two-Stream Convolutional Neural Networks for Breathing Pattern Classification: Real-Time Monitoring of Respiratory Disease Patients
Authors: Park Jinho , Nguyen Thien , Park Soongho , Hill Brian , Shadgan Babak , Gandjbakhche Amir
Published: July 2024

A two-stream convolutional neural network (TCNN) for breathing pattern classification has been devised for the continuous monitoring of patients with infectious respiratory diseases. The TCNN consists of a convolutional neural network (CNN)-based autoencoder and classifier. The encoder of the autoencoder generates deep compressed feature maps, which contain the most important information constituting data. These maps are concatenated with feature maps generated by the classifier to classify breathing patterns. The TCNN, single-stream CNN (SCNN), and state-of-the-art classification models were applied to classify four breathing patterns: normal, slow, rapid, and breath holding. The input data consisted of chest tissue hemodynamic responses measured using a wearable near-infrared spectroscopy device on 14 healthy adult participants. Among the classification models evaluated, random forest had the lowest classification accuracy at 88.49%, while the TCNN achieved the highest classification accuracy at 94.63%. In addition, the proposed TCNN performed 2.6% better in terms of classification accuracy than an SCNN (without an autoencoder). Moreover, the TCNN mitigates the issue of declining learning performance with increasing network depth, as observed in the SCNN model. These results prove the robustness of the TCNN in classifying breathing patterns despite using a significantly smaller number of parameters and computations compared to state-of-the-art classification models.
Semaphorin 4A Maintains Trophoblastic Function via Activating the STAT3 Pathway
Authors: Hou Taotao , Zhang Pingping , Tian Haishen , Luo Yan , Li Juan , Zhang Kuo , Li Yali
Published: July 2024

The migration, proliferation, and apoptosis of trophoblastic cells play a crucial role in ensuring the effective preservation of pregnancy at the maternal–fetal interface. Any deviations in the structure and function of these cells might potentially result in the development of numerous pregnancy-related disorders, including missed abortion (MA). This study involved the examination of semaphorin 4A (SEMA4A) expression in missed abortion (n = 18) and normal early pregnancy (n = 18) villus. The findings of this study indicate a statistically significant decrease in the expression of SEMA4A in the villi of individuals diagnosed with missed abortion, as compared to the control group. The results of our vitro study showed that SEMA4A promoted the migration and proliferation of trophoblast cells and inhibited their apoptosis. Subsequent studies have shown that SEMA4A may be involved in regulating p-STAT3/STAT3, MMP9, bcl-2, and BAX levels. In summary, the findings of this study indicate a correlation between the decreased level of SEMA4A in chorionic villi and missed abortion. These results offer novel theoretical insights into the proper implantation and development of SEMA4A embryos at the maternal–fetal interface.
Targeting Microglia in Alzheimer’s Disease: Pathogenesis and Potential Therapeutic Strategies
Authors: Sun Zhongqing , Zhang Xin , So Kwok-Fai , Jiang Wen , Chiu Kin
Published: July 2024

Microglia, as resident macrophages in the central nervous system, play a multifunctional role in the pathogenesis of Alzheimer’s disease (AD). Their clustering around amyloid-β (Aβ) deposits is a core pathological feature of AD. Recent advances in single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) have revealed dynamic changes in microglial phenotypes over time and across different brain regions during aging and AD progression. As AD advances, microglia primarily exhibit impaired phagocytosis of Aβ and tau, along with the release of pro-inflammatory cytokines that damage synapses and neurons. Targeting microglia has emerged as a potential therapeutic approach for AD. Treatment strategies involving microglia can be broadly categorized into two aspects: (1) enhancing microglial function: This involves augmenting their phagocytic ability against Aβ and cellular debris and (2) mitigating neuroinflammation: Strategies include inhibiting TNF-α signaling to reduce the neuroinflammatory response triggered by microglia. Clinical trials exploring microglia-related approaches for AD treatment have garnered attention. Additionally, natural products show promise in enhancing beneficial effects and suppressing inflammatory responses. Clarifying microglial dynamics, understanding their roles, and exploring novel therapeutic approaches will advance our fight against AD.
Biomimetic Antifungal Materials: Countering the Challenge of Multidrug-Resistant Fungi
Authors: Khalifa Hazim O. , Oreiby Atef , Abdelhamid Mohamed A. A. , Ki Mi-Ran , Pack Seung Pil
Published: July 2024

In light of rising public health threats like antifungal and antimicrobial resistance, alongside the slowdown in new antimicrobial development, biomimetics have shown promise as therapeutic agents. Multidrug-resistant fungi pose significant challenges as they quickly develop resistance, making traditional antifungals less effective. Developing new antifungals is also complicated by the need to target eukaryotic cells without harming the host. This review examines biomimetic antifungal materials that mimic natural biological mechanisms for targeted and efficient action. It covers a range of agents, including antifungal peptides, alginate-based antifungals, chitosan derivatives, nanoparticles, plant-derived polyphenols, and probiotic bacteria. These agents work through mechanisms such as disrupting cell membranes, generating reactive oxygen species, and inhibiting essential fungal processes. Despite their potential, challenges remain in terms of ensuring biocompatibility, optimizing delivery, and overcoming potential resistance. Production scalability and economic viability are also concerns. Future research should enhance the stability and efficacy of these materials, integrate multifunctional approaches, and develop sophisticated delivery systems. Interdisciplinary efforts are needed to understand interactions between these materials, fungal cells, and the host environment. Long-term health and environmental impacts, fungal resistance mechanisms, and standardized testing protocols require further study. In conclusion, while biomimetic antifungal materials represent a revolutionary approach to combating multidrug-resistant fungi, extensive research and development are needed to fully realize their potential.
Artificial Light at Night Increases Growth and Impairs Reproductive Success in Budgerigars (Melopsittacus undulatus) in a Duration Dose-Dependent Manner
Authors: Itay Malek , Haim Abraham
Published: July 2024

Short-wavelength artificial light at night is increasingly being associated with health and ecological risks. The negative impact of this relatively new source of pollution has been studied intensively in wild birds but to a much lesser extent in captive conspecifics. Using an avian model, our objective was to evaluate the effects of short-wavelength (200 lux at 460 nm) lighting on the body mass and reproductive success of Budgerigars (Melopsittacus undulatus) under captive conditions. Birds were maintained under a naturally increasing photoperiod from March to June, with one daily artificial light at night exposure of increasing duration (0, 30, 60, and 90 min) in the middle of the dark period. During the experiments, birds were monitored monthly for body mass, number of eggs laid, hatching success, and melatonin sulfate levels in droppings. Artificial light at night increased body mass and decreased melatonin sulfate levels as well as the number of eggs and hatching success in a duration dose-dependent manner. Our findings provide further evidence of the potential adverse impact of artificial light at night on captive birds and advocate the need for effective controlling measures for light pollution.
Supply-Blockchain Functional Prototype for Optimizing Port Operations Using Hyperledger Fabric
Authors: Alkhaldi Bidah , Al-Omary Alauddin
Published: July 2024

Supply chain bottlenecks in port operations lead to significant delays and inefficiencies. Blockchain technology emerges as a viable solution, offering tamper-resistant ledgers, secure transactions, and automation capabilities. While considerable research on developing blockchain-based solutions currently exist, there is a lack of studies that specifically focus on optimizing port document management to speed up supply chain operations. In this paper, a supply-blockchain functional prototype for optimizing port operations using Hyperledger Fabric is introduced. In terms of core functionality, the prototype allows initiation of smart contract corresponding to functions such as creating and editing port-related documents, minimizing manual interventions and enhancing efficiency to reduce port congestion. Furthermore, it provides live tracking of completed events and transactions, facilitating transparency and streamlined oversight. The permissioned nature of Hyperledger Fabric ensures security and robust access controls, aligning well with sensitive port operations. Hyperledger Firefly and its connector framework was used as the middleware to facilitate blockchain integration and various functions of the prototype, while chaincode developed using Go language was used to package and deploy smart contracts. The supply-blockchain framework was used as the theoretical framework for prototype development, and agile project management was adopted to ensure timely completion. The results based on functional and performance testing demonstrate the prototype’s potential in alleviating port documentation bottlenecks and quickly delivering benefits to key stakeholders.
Blockchain Technology Application Domains along the E-Commerce Value Chain—A Qualitative Content Analysis of News Articles
Authors: Witt Josepha , Schoop Mareike
Published: July 2024

Blockchain Technology (BCT) offers several possible applications in the field of electronic commerce (e-commerce), such as decentralised marketplaces or payments in cryptocurrencies. Even though these applications of BCT have already been explored in the academic literature, a comprehensive collection along the whole e-commerce value chain is still missing. Furthermore, the existing comprehensive reviews are based on the academic literature whilst the evolution and further development of BCT is highly driven by practitioners. Therefore, we aim to understand how and why BCT is used in e-commerce based on a qualitative content analysis of news articles, i.e., we apply scientific methods to content which reports the latest developments in the field. As a result, we describe the multiple application domains of BCT along the e-commerce value chain. Subsequently, we discuss the main underlying principles of BCT usage across all the value chain steps.
Nature-Based Therapeutic Intervention for Individuals with Post-Concussion Symptoms
Authors: Corazon Sus Sola , Olsen Lisbeth Jul , Kæreby Natasha , Poulsen Dorthe Varning , Sidenius Ulrik , Bekke-Hansen Stine , Marschner Linda
Published: July 2024

This study investigated the efficacy of a 10-session nature-based therapeutic intervention for people with post-concussion symptoms. The intervention involved physical and vestibular exercises, sensory training, relaxation, and psychoeducation, all of which were integrated with the natural environment in a forest therapy garden. This study was designed with a passive control period followed by the intervention (n = 30). The Mental Fatigue Scale (MFS) was the primary outcome measure. The secondary outcome measures were the Warwick–Edinburg Mental Wellbeing Scale and the short version of the Quality of Life after Brain Injury. A Likert scale was used to examine the mental strain of the sessions themselves. The MFS (primary outcome) exhibited a significant decrease with a medium-sized effect from before to after the intervention. The secondary outcomes exhibited significant increases from the beginning to the end of the intervention. All outcomes were sustained at follow-up ten weeks later. No significant difference was found from the control period. This study indicates that the described nature-based intervention is a feasible treatment for reducing prolonged post-concussion symptoms. However, it should be studied more in-depth to understand the impact of the natural environment and to validate the results on a larger representative population.
Mechanical Properties, Workability, and Experiments of Reinforced Composite Beams with Alternative Binder and Aggregate
Authors: Marcalikova Zuzana , Jerabek Jan , Gandel Radoslav , Gabor Roman , Bilek Vlastimil , Sucharda Oldrich
Published: July 2024

Arguably the most important element in the sustainability of concrete development is the discovery of an optimal sustainable binder and substitution for the increasingly depleted reserves of natural aggregates. Considerable interest has been shown in alkali-activated materials, which possess good characteristics and could be considered environmentally friendly because of their use of secondary materials in production. The aim of this study was the determination of the mechanical properties of three different mixtures based on the same locally accessible raw materials. The reference mixture contained Portland cement, the second mix contained a finely ground granulated blast furnace slag instead of cement, and the third mixture contained a portion of light artificial aggregate. The experiments focused on the testing and mutual comparison of the processability of the fresh mixture and mechanical characteristics (like compressive and flexural strength, as well as resistance to high temperatures and surface layer tear strength tests). Reinforced concrete beams without shear reinforcement and with three levels of reinforcement were also tested with a three-point bend test. The results show that, overall, the mechanical properties of all the tested mixtures were similar, but each had its own disadvantages. For example, the blast furnace slag-based mixture had a more vulnerable surface layer or a debatable loss of bulk density in the light aggregate mix at the expense of the mechanical properties. One of the main results of the research is that it was possible to technologically produce beams from the alkali-activated concrete (AAC) mixture. Then, the performed beam experiments verified the mechanism of damage, collapse, and load capacity. The obtained results are essential because they present the use of AAC not only in laboratory conditions but also for building elements. In beams without shear reinforcement, the typical tensile cracks caused by bending and shear cracks appeared under loading, where their character was affected depending on the degree of beam reinforcement and loading.
Bonding Performance and Microstructural Mechanism between Rapid Repair Materials and Old Concrete Pavement
Authors: Bao Kan , Zhang Gaowang , Lv Jiangpeng , Li Junmin , Chen Zexin , Yuan Jie
Published: July 2024

In China, airports predominantly utilize airport cement concrete pavement, which inevitably undergoes deterioration in service. To uphold pavement durability and functionality, and ensure aircraft operational safety, prompt repairs of affected areas are imperative. Therefore, ordinary Portland cement mortars were used as the control group to compare and analyze the bonding performances of two common airport pavement repair materials: modified Portland cement mortars and phosphate cement mortars. Meanwhile, through microscopic experiments, the microscopic characteristics of the interfacial transition zone (ITZ) were studied, and the interface bonding mechanism was analyzed. The research results indicate that the interface bonding strength between phosphate cement mortar and old concrete pavement is the highest. This was because the elements in phosphate cement penetrated the old concrete pavement through hydration reactions, forming van der Waals forces and chemical bonding forces. In addition, the research results indicated that the presence of old concrete pavement made the three repair materials produce similar sidewall effects with the old concrete pavement, leading to a low hydration degree of the repair materials. However, the chemical bonding and penetrating structure of phosphate cement compensated for the weakening effect of the ITZ in the repair materials.
Sentinel Lymph Node Detection in Cutaneous Melanoma Using Indocyanine Green-Based Near-Infrared Fluorescence Imaging: A Systematic Review and Meta-Analysis
Authors: Wölffer Marcus , Liechti Rémy , Constantinescu Mihai , Lese Ioana , Zubler Cédric
Published: July 2024

The standard of care approach to identify sentinel lymph nodes (SLNs) in clinically non-metastatic cutaneous melanoma patients is technetium (Tc)-based lymphoscintigraphy. This technique is associated with radiation exposure, a long intervention time, high costs, and limited availability. Indocyanine green (ICG)-based near-infrared fluorescence imaging offers a potential alternative if proven to be of comparable diagnostic accuracy. While several clinical cohorts have compared these modalities, no systematic review exists that provides a quantitative analysis of their results. Hence, a systematic literature review was conducted in December 2023 considering clinical studies comparing the diagnostic accuracy of ICG and Tc for sentinel lymph node biopsy in cutaneous melanoma patients. Three hundred nineteen studies were identified and further screened in accordance with the PRISMA 2020 guidelines, resulting in seven studies being included in the final meta-analysis. Tc identified a significantly higher number of SLNs and metastatic SLNs in prospective studies only. However, in the overall meta-analysis of all included comparative studies, no significant differences were found regarding the identification of metastatic patients or the false negative rate (FNR). ICG may be a non-inferior alternative to Tc for intraoperative guidance in sentinel lymph node biopsy in cutaneous melanoma patients. Future randomized controlled trials are needed, especially regarding the preoperative, transcutaneous identification of the affected lymph node basin.
Advancing Plastic Recycling: A Review on the Synthesis and Applications of Hierarchical Zeolites in Waste Plastic Hydrocracking
Authors: Azam Muhammad Usman , Afzal Waheed , Graça Inês
Published: July 2024

The extensive use of plastics has led to a significant environmental threat due to the generation of waste plastic, which has shown significant challenges during recycling. The catalytic hydrocracking route, however, is viewed as a key strategy to manage this fossil-fuel-derived waste into plastic-derived fuels with lower carbon emissions. Despite numerous efforts to identify an effective bi-functional catalyst, especially metal-loaded zeolites, the high-performing zeolite for hydrocracking plastics has yet to be synthesized. This is due to the microporous nature of zeolite, which results in the diffusional limitations of bulkier polymer molecules entering the structure and reducing the overall cracking of plastic and catalyst cycle time. These constraints can be overcome by developing hierarchical zeolites that feature shorter diffusion paths and larger pore sizes, facilitating the movement of bulky polymer molecules. However, if the hierarchical modification process of zeolites is not controlled, it can lead to the synthesis of hierarchical zeolites with compromised functionality or structural integrity, resulting in reduced conversion for the hydrocracking of plastics. Therefore, we provide an overview of various methods for synthesizing hierarchical zeolites, emphasizing significant advancements over the past two decades in developing innovative strategies to introduce additional pore systems. However, the objective of this review is to study the various synthesis approaches based on their effectiveness while developing a clear link between the optimized preparation methods and the structure-activity relationship of the resulting hierarchical zeolites used for the hydrocracking of plastics.
Correction: Bagchi et al. Effects of Carboxyl Functionalized CNT on Electrochemical Behaviour of Polyluminol-CNT Composites. Chemistry 2022, 4, 1561–1575
Authors: Bagchi Raunaq , Elshazly Mohamed , N’Diaye Jeanne , Yu Dian , Howe Jane Y. , Lian Keryn
Published: July 2024

There was an error in the original publication [...]
Family and Peer Social Capital and Child Behavioral Outcomes in Japan
Authors: Poff Jared M. , Jarvis Jonathan A. , Dufur Mikaela J. , Pribesh Shana L.
Published: July 2024

Background/Objectives: Child problem behaviors have been linked to immediate and long-term negative outcomes. Research has found that family and peer social capital have a strong influence on child behavioral outcomes. However, most research about social capital and child behavior problems has been conducted in Western contexts. Social capital may influence child behavior problems differently in non-Western sociocultural environments due to different family and peer dynamics. Methods: Using a sample from the Japan Household Panel Survey and Japan Child Panel Survey (N = 182), we expand this literature on various forms of social capital to the Japanese context with data that were collected between 2009 and 2014. We examine the relationship of family and peer social capital with children internalizing and externalizing problem behaviors using OLS linear regression. Results: Our results differ from what is commonly found in Western contexts. Whereas family and peer social capital are typically associated with both internalizing and externalizing problem behaviors in Western countries, we find that greater family social capital is associated with decreased externalizing problem behaviors but not internalizing problem behaviors in Japan, and peer social capital has no association on either type of problem behaviors. Conclusions: Our findings emphasize the importance of considering social and cultural contexts when exploring how social capital might encourage prosocial child outcomes.
Characterization of Uncoated and Coated Fungal Mycelium-Based Composites from Water Hyacinth
Authors: Sakunwongwiriya Puangpetch , Taweepreda Wirach , Luenram Siwapong , Chungsiriporn Juntima , Iewkittayakorn Jutarut
Published: July 2024

Mycelium-based composites are a promising avenue for innovating sustainable materials from the hyphae of fungi. This study focuses on the use of fibers from four local fungal species, namely, Pleurotus ostreatus, Pleurotus sajor-caju (Fr. Singer), Auricularia auricula-judae, and Schizophyllum commune Fr., to produce mycelium-based composites from water hyacinth. An inoculum of each of the mushroom species was cultivated on PDA medium at 25 and 30 °C to determine the optimal temperature based on the growth rate. The obtained optimal condition was used to grow the fungi on water hyacinth (WH) mixed with rice bran in different proportions (100% WH, 70% WH, and 50% WH) with various numbers of fungal inocula (10, 20, and 30 plugs). The obtained composites were coated with a solution of either starch, chitosan, or epoxy resin. Schizophyllum commune Fr. exhibited the highest growth rate and fiber density, with a growth rate of 1.45 ± 1.92 mm/day at 30 °C. Ten inocula of Schizophyllum commune Fr. incubated at 30 °C for seven days on a mixture of 50% WH and 50% rice bran gave the optimal composite. Coating the obtained composite with chitosan improved its mechanical properties, but coating it with epoxy resin improved its water absorbency. Buried in soil, the composite coated with a chitosan solution decomposed within 30 days. The results indicate that Schizophyllum commune Fr. can be used as a binder to produce mycelial composites on a substrate of WH mixed with rice bran. The implications of these results will enable the further development and tuning of mushroom-based materials, especially for the production of sustainable bio-construction materials derived from local mushrooms and bio-waste.