bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrospective analysis of pregnancies resulted from assisted reproductive technology in women with type 2 diabetes mellitus
Authors: Misharina Elena V. , Borovik Natalia V.
Published: July 2019

Hypothesis/aims of study. Type 2 diabetes mellitus (T2D) is one of the most widespread diseases in the world. The etiology of this disease is associated with genetic, age and ethnic factors. It is generally accepted that a sedentary lifestyle and obesity can cause T2D. This illness has serious complications that affect the women’s health and quality of life. It is well known that obesity and T2D are a common cause of anovulatory infertility in women of reproductive age. The number of T2D patients who are planning pregnancy by assisted reproductive technology (ART) has increased over the past 10 years. This study was aimed at investigating the effect of carbohydrate metabolism compensation in the preconception period on the outcomes of pregnancies resulted from in vitro fertilization (IVF) in T2DM women.
Study design, materials, and methods. 51 T2D pregnancies after ART and their outcomes were analyzed retrospectively.
Results. The age of the patients who applied to ART departments ranged from 27 to 46 years. The mean body mass index was 33.9 ± 6.5 kg/m2. The duration of infertility varied from 3 to 18 years. Infertility was caused by tubal occlusion in 17 cases, by anovulation in 16 cases, by male factor in 9 cases, by genital endometriosis in 7 cases, and by hypergonadotropic hypogonadism in 2 cases. One of the patients underwent IVF procedure twice in 4 years. All T2D patients received prepregnancy care including weight loss, diabetes compensation, diabetes complications treatment, and, if necessary, a transfer to insulin therapy and insulin treatment education for 1–2 months before entering into the IVF protocol. Angiotensin-converting enzyme inhibitors and statins should be stopped if they were prescribed in case of hypertension or dyslipidemia and other medications allowed during pregnancy should be started. 26 women (51%) did not take periconceptional multivitamin supplementation before IVF procedure. The level of glycated hemoglobin (HbA1c) in this group was 6.4 ± 0.5%. 25 patients (49%) underwent incomplete preparation for pregnancy before entering into the IVF protocol but not in full. An important stage of prepregnancy care was weight loss in women with overweight and obesity. The duration of a prepregnancy care program varied from 2 to 6 months and on average was 3.8 ± 1.7 months. The mean HbA1c level in this group was 5.8 ± 0.4%. All cases of IVF pregnancies in women with T2D resulted with live birth. The incidence of preeclampsia, cesarean section delivery, and preterm labor was lower in the group of women who had been given prepregnancy care.
Conclusion. Proper prepregnancy care including weight loss, diabetes compensation, early start of insulin therapy, and diabetes complications treatment before conception is an effective method of preventing perinatal complications in women with T2D.
Genital endometriosis and melatonin: a role in the pathogenesis and its possible use in the treatment of the disease
Authors: Yarmolinskaya Maria I. , Tkhazaplizheva Saimat Sh. , Molotkov Arseniy S. , Tkachenko Natalia N. , Borodina Valentina L. , Andreyeva Nelli Yu. , Kleymyonova Tatyana S. , Lysenko Vera V.
Published: July 2019

Hypothesis/aims of study. Melatonin is found in almost all living organisms, the range of its effects being quite diverse. Effects of this hormone in the human body are realized via two ways, through specific receptors and non-receptor pathways. Melatonin may act through both membrane and nuclear receptors. In the present work, the expression of MTR1 and MTR2 melatonin receptors was studied in the eutopic endometrium and endometrioid heterotopies, and the level of melatonin metabolite, 6-sulfatoxymelatonin, in daily urine in patients with genital endometriosis (GE) was analyzed.
Study design, materials and methods. The experimental group included 67 patients of reproductive age with a verified diagnosis of GE, and the control group consisted of 18 individuals with an ovulatory menstrual cycle without gynecological pathology. The 6-sulfatoxymelatonin level in daily urine was determined by enzyme immunoassay. The study of MTR1 and MTR2 melatonin receptor expression in the endometrium and endometrioid heterotopies was performed in 24 patients with GE and in 10 women of reproductive age who were examined for infertility who did not have gynecological pathology based on diagnostic laparoscopy. To study the expression of melatonin receptors, the endometrium and endometrial heterotopy sampling was carried out from day 18 to day 22 of the menstrual cycle. Morphological assessment included histological and immunofluorescence studies using confocal laser scanning microscopy.
Results. In patients with GE, there was found a tendency to a decrease in 6-sulfatoxymelatonin excretion in daily urine compared to the control group. It was also found that the total relative expression area of melatonin receptors in the endometrium of women with GE was significantly lower compared to the endometrium of patients from the control group. Significant differences between the average brightness and optical density were not found. In addition, it was revealed that the relative expression areas of MTR1 and MTR2 melatonin receptors in the eutopic endometrium and in endometrioid heterotopies did not differ significantly. A negative correlation was stated between the relative expression area of melatonin receptors and GE prevalence. Particular attention is paid to the role of melatonin in the development of GE and to the possibilities of working out new treatment regimens with its use.
Conclusion. The data obtained confirm the undoubted role of melatonin in the pathogenesis of GE, however, the development of new treatment regimens with its use requires further study.
Inhibin as a reproductive biomarker. Part 1
Authors: Abdulkadyrova Zarina K. , Abashova Elena I.
Published: July 2019

Inhibin is one of the most important hormones of the reproductive system, which is secreted by the granulose cells of the ovary and the Sertoli cells of the testes. Inhibin regulates follicle-stimulating hormone secretion involving a negative feedback loop, participates in ovarian folliculogenesis and spermatogenesis, and has great diagnostic potential in assessing the reproductive status and treating reproductive disorders. More than 90 years have passed since the discovery of inhibin, and it is becoming increasingly clear that its action is not limited to the reproductive system, as the hormone subunits and dimers are found in many organs. Further research is needed to study physiological functions of inhibin and diagnostic possibilities of its use in modern medicine. This review examines the structure and various biological functions of inhibin, as well as its role in human reproduction.
Association of hypothyroidism and polycystic ovarian syndrome: a study in a semi urban area
Authors: Ram Babu M. V. , Vittal D. Sai
Published: July 2019

Background: Polycystic ovarian syndrome reported to be one of the most common endocrine disorders in the women of the reproductive age, causing oligoovulatory infertility. In many cases, apparently healthy looking women are being diagnosed with either subclinical or overt hypothyroidism after having the symptoms of PCOS. This study was done to analyse the association of PCOS and hypothyroidism in our geographical area.Methods: 50 women of reproductive ages between 18 to 45 years, who were diagnosed with PCOS, based on Rotterdam’s criteria, 2003 and 50 healthy women as controls, were included into the study. After taking the demographic details from all the patients, they were all subjected to ultrasound for the detection of the cysts. Blood was collected for various biochemical tests including the thyroid profile. Results: The mean age of all the patients in the study group was 23.6±7.2 compared to 27.1±4.6 of the healthy controls. The Body Mass Index amongst both the groups was 29.1±3.1 and 23.4±2.9 kg/m2 respectively. The levels of thyroid profile were significantly high among the study group with 58%, 54%, 68% as the number of patients with elevated T3, T4 and TSH values. The prevalence of subclinical hypothyroidism was 48.3%, while 51.7% of them had overt hypothyroidism. A higher BMI was found among the patients with PCOS and hypothyroidism.Conclusion: The prevalence of hypothyroidism among the PCOS patients is certainly on the rise accentuating its association with this endocrine disorder especially among the young adults.
Prevalence of left ventricular diastolic dysfunction among patients with asymptomatic diabetes mellitus type 2
Authors: Vittal D. Sai , Ram Babu M. V.
Published: July 2019

Background: Diastolic heart failure occurs due to impaired myocardial relaxation and compliance. Of late, it has been suggested that the changes in the diastolic function occurs before the onset of diabetes, and present in the prediabetic patients. It is also said to be associated with insulin resistance.Methods: This observational study was performed on 50 diabetic patients, with asymptomatic type 2 diabetes. who came in for 2 D echocardiogram with suspected diastolic dysfunction.Results: The mean age among the 50 patients in the study was 54.1±10.99 years and in controls it was 49.56±10.63 years. The fasting sugar among the patients was 179.43±41.57 mg/dl and the post prandial was 236.72±76.24, and it was in the normal range in the controls. The HbA1c was 9.93±1.2 among the patients and 6.09 ± 0.34 in the controls. In the patients, the E/A ratio was 0.83±0.09 compared to 1.22±0.31 of the controls, which was highly significant as the E/e ratio which was 15.1±3.4 and 7.3±0.08 respectively.Conclusions: There was a higher prevalence of diastolic dysfunction among the patients with diabetes in our study. There was no relation of age or gender among the diabetic and the controls, while a strong association and indicators seem to be FBS, PLBS and HbA1c.
Arginuzy, Sokrates, Nietzsche, metafizyczny paralelizm i dzienniczek gimnazjalisty
Authors: Staniszewski Maciej
Published: July 2019

This articles is a short analysis of the first entry in Aleksander Kozhevnikov’s (Kojève) Diary of a Philosopher, dedicated to the battle of Arginusae and subsequent trial of Athenian generals. A great discrepancy between facts – as presented by young Kozhevnikov – and ancient sources and their interpretation in modern scholarship leads to an attempt to find out the contemporary inspiration of this short text, followed by some remarks on previous interpretations of this very first ‘philosophical’ essay of young Kojève.
Neuropeptide FF (FLFQPQRF-NH2) and its Fragments Bind to α2δ Subunit of Voltage-Gated Calcium Channels
Authors: Skubatz Hanna
Published: July 2019

Purpose: Gabapentin, a drug for neuropathic pain, exerts its therapeutic effect via inhibition of the a2d subunit of N-type Ca2+ channels. Thus, finding peptides that specifically displace gabapentin from its binding site may lead to the development of new drugs. Methods: Displacement of bound [3H]-gabapentin in membrane preparations of rat cerebral cortex and of human Cav2.2/β3/α2δ1 expressed in CHO cell line. Results: Neuropeptide FLFQPQRF-NH2 specifically displaced bound [3H]-gabapentin in membrane preparations from rats and CHO cells. Truncation of the C-terminus of FLFQPQRF-NH2 by three amino acid residues to produce FLFQP-NH2 improved the displacement of gabapentin. FLFQP-NH2 displaced bound  [3H]-gabapentin with IC50 and Ki values of 2.7 µM and 1.7 µM, respectively. Deletion of two amino acid residues (FQ) in the middle of the FLFQP-NH2 sequence yielded FLP-NH2 that displaced bound [3H]-gabapentin with a lower affinity.  IC50 and Ki values were 11.9 µM and 7.8 µM, respectively. Neutral binding cooperativity existed when of FLFQP-NH2, FLP- NH2 and gabapentin when incubated together. FLFQPQRF-NH2 but not FLFQP-NH2 displaced bound [3H]-gabapentin to membrane preparations of human Cav2.2/b3/a2d1 expressed in CHO cells. Conclusion: FLFQPQRF-NH2, FLFQP-NH2 and FLP-NH2 displace bound gabapentin in membrane preparations of rat cerebral cortex. Binding cooperativity was detected when GBP/FLFQP-NH2/FLP-NH2 were incubated together. These novel binding sites may provide new approaches to modulate L-type Ca2+ channels.
Perceived social support in mothers of typically developing children and mothers of children with hearing sensory impairment
Authors: Hemati Alamdarloo Ghorban , Rangani Aghdas , Rostami Sedighe , Morovat Monire
Published: July 2019

Background and Aim: Children with sensory impairments can bring stress to their parents. The purpose of this study was to compare per­ceived social support in mothers of children with hearing impairment, visual impairment, and typically developing children in Shiraz City, Iran.Methods: The study sample consisted of 139 mothers of normal children and children with sensory impairment (50 mothers of children with hearing impairment, 39 mothers of children with visual impairment, and 50 mothers of typ­ically developing children). The Multidimensio­nal Scale of Perceived Social Support was used to measure perceived social support. One-way ANOVA and multivariate analysis of variance (MANOVA) were respectively used for analy­zing the total score of perceived social support and the scores of its subscales.
Conclusion: The provision of counseling servi­ces and the implementation of appropriate inter­ventions for mothers of children with hearing impairment and mothers of children with visual impairment is necessary.
The role of transposable elements in the ecological morphogenesis under the influence of stress
Authors: Mustafin R. N. , Khusnutdinova E. K.
Published: July 2019

In natural selection, insertional mutagenesis is an important source of genome variability. Transposons are sensors of environmental stress effects, which contribute to adaptation and speciation. These effects are due to changes in the mechanisms of morphogenesis, since transposons contain regulatory sequences that have cis and trans effects on specific protein-coding genes. In variability of genomes, the horizontal transfer of transposons plays an important role, because it contributes to changing the composition of transposons and the acquisition of new properties. Transposons are capable of site-specific transpositions, which lead to the activation of stress response genes. Transposons are sources of non-coding RNA, transcription factors binding sites and protein-coding genes due to domestication, exonization, and duplication. These genes contain nucleotide sequences that interact with non-coding RNAs processed from transposons transcripts, and therefore they are under the control of epigenetic regulatory networks involving transposons. Therefore, inherited features of the location and composition of transposons, along with a change in the phenotype, play an important role in the characteristics of responding to a variety of environmental stressors. This is the basis for the selection and survival of organisms with a specific composition and arrangement of transposons that contribute to adaptation under certain environmental conditions. In evolution, the capability to transpose into specific genome sites, regulate gene expression, and interact with transcription factors, along with the ability to respond to stressors, is the basis for rapid variability and speciation by altering the regulation of ontogenesis. The review presents evidence of tissue-specific and stage-specific features of transposon activation and their role in the regulation of cell differentiation to confirm their role in ecological morphogenesis.
Genetic approaches to the investigation of serotonergic neuron functions in animals
Authors: Drozd U. S. , Shaburova E. V. , Dygalo N. N.
Published: July 2019

The serotonergic system is one of the most important neurotransmitter systems that take part in the regulation of vital CNS functions. The understanding of its mechanisms will help scientists create new therapeutic approaches to the treatment of mental and neurodegenerative diseases and find out how this neurotransmitter system interacts with other parts of the brain and regulates their activity. Since the serotonergic system anatomy and functionality are heterogeneous and complex, the best tools for studying them are based on manipulation of individual types of neurons without affecting neurons of other neurotransmitter systems. The selective cell control is possible due to the genetic determinism of their functions. Proteins that determine the uniqueness of the cell type are expressed under the regulation of cell-specific promoters. By using promoters that are specific for genes of the serotonin system, one can control the expression of a gene of interest in serotonergic neurons. Here we review approaches based on such promoters. The genetic models to be discussed in the article have already shed the light on the role of the serotonergic system in modulating behavior and processing sensory information. In particular, genetic knockouts of serotonin genes sert, pet1, and tph2 promoted the determination of their contribution to the development and functioning of the brain. In addition, the review describes inducible models that allow gene expression to be controlled at various developmental stages. Finally, the application of these genetic approaches in optogenetics and chemogenetics provided a new resource for studying the functions, discharge activity, and signal transduction of serotonergic neurons. Nevertheless, the advantages and limitations of the discussed genetic approaches should be taken into consideration in the course of creating models of pathological conditions and developing pharmacological treatments for their correction.
Genetic basis of depressive disorders
Authors: Davydova Yu. D. , Enikeeva R. F. , Kazantseva A. V. , Mustafin R. N. , Romanova A. R. , Malykh S. B. , Khusnutdinov E. K.
Published: July 2019

Depression is a common mental disorder being one of the main causes of disability and mortality worldwide. Despite an intensive research during the past decades, the etiology of depressive disorders (DDs) remains incompletely understood; however, genetic factors are significantly involved in the liability to depression. The present review is focused on the studies based on a candidate gene approach, genome-wide association studies (GWAS) and whole exome sequencing (WES), which previously demonstrated associations between gene polymorphisms and DDs. According to the first approach, DD development is affected by serotonergic (TPH1, TPH2, HTR1A, HTR2A, and SLC6A4), dopaminergic (DRD4, SLC6A3) and noradrenergic (SLC6A2) system genes, and genes of enzymatic degradation (MAOA, COMT). In addition, there is evidence of the involvement of HPA-axis genes (OXTR, AVPR1A, and AVPR1B), sex hormone receptors genes (ESR1, ESR2, and AR), neurotrophin (BDNF) and methylenetetrahydrofolate reductase (MTHFR) genes, neuronal apoptosis (CASP3, BCL-XL, BAX, NPY, APP, and GRIN1) and inflammatory system (TNF, CRP, IL6, IL1B, PSMB4, PSMD9, and STAT3) genes in DD development. The results of the second approach (GWAS and WES) revealed that the PCLO, SIRT1, GNL3, GLT8D1, ITIH3, MTNR1A, BMP5, FHIT, KSR2, PCDH9, and AUTS2 genes predominantly responsible for neurogenesis and cell adhesion are involved in liability to depression. Therefore, the findings discussed suggest that genetic liability to DD is a complex process, which assumes simultaneous functioning of multiple genes including those reported previously, and requires future research in this field.
Materialne aspekty kompetencji prawotwórczych gmin w świetle znowelizowanej ustawy o wychowaniu w trzeźwości i przeciwdziałaniu alkoholizmowi
Authors: Lewicki Marek
Published: July 2019

Celem artykułu jest przybliżenie i analiza wybranych aspektów zmian w zakresie prawotwórczych kompetencji gmin na gruncie ustawy o wychowaniu w trzeźwości i przeciwdziałaniu alkoholizmowi. Podkreślić należy, iż kompetencje te należą do kluczowych instrumentów służących realizacji założeń ustawy, stąd każda zmiana prawa w tym zakresie wymaga szczególnej uwagi. W artykule podjęto próbę określenia zarówno możliwości wynikających z obowiązującego prawa, jak i ograniczeń w kształtowaniu przez organy gmin treści rozstrzygnięć prawotwórczych, podejmowanych na podstawie upoważnień zawartych w ustawie.
Aspekty bezpieczeństwa publicznego w planowaniu przestrzennym
Authors: Pilarz Karina
Published: July 2019

Zapewnienie bezpieczeństwa publicznego jest jednym z najważniejszych zadań spoczywających na państwie, co wynika m.in. z treści art. 5 Konstytucji Rzeczypospolitej Polskiej. Prawodawca w tekstach aktów normatywnych często posługuje się pojęciem bezpieczeństwa pub­licznego, jednak w żadnym z nich nie znajdziemy jego definicji legalnej. Zapewnieniem bezpieczeństwa publicznego zajmuje się wiele rodzajów podmiotów, od organów administracji rządowej, przez wyspecjalizowane jednostki, organy samorządu terytorialnego i organizacje samorządowe, aż po podmioty prywatne. Bezpieczeństwo publiczne jest również czynnikiem determinującym proces planowania przestrzennego, jego zapewnienie bowiem musi być uwzględnione przy planowaniu przyszłego zagospodarowania przestrzeni. Obowiązek ten wynika wprost z art. 1 ustawy o planowaniu i zagospodarowaniu przestrzennym.
Likwidacja Biura Ochrony Rządu, utworzenie Służby Ochrony Państwa
Authors: Ura Elżbieta
Published: July 2019

Celem artykułu jest zwrócenie uwagi na podstawowe zagadnienia związane z funkcjonowaniem nowo utworzonej Służby Ochrony Państwa w miejsce dotychczas działającego Biura Ochrony Rządu. Przedstawione zostały przyczyny utworzenia nowej formacji, zawarte w uzasadnieniu do projektu ustawy. Zwrócono uwagę na przyznanie nowej formacji uprawnień do prowadzenia czynności operacyjno-rozpoznawczych. Ponadto wspomniano o przyjęciu unormowań pozwalających na wygaśnięcie stosunków służbowych funkcjonariuszy i pracowników BOR w przypadku, gdy nie otrzymali oni propozycji dalszej służby lub pracy.
Kłamanie jako akt mowy – kilka uwag z perspektywy filozoficzno-prawnej
Authors: Kołodziejczyk Joanna
Published: July 2019

W artykule przedstawiono zagadnienia dotyczące analizy natury (istoty) kłam­stwa z perspektywy pragmatyki logicznej. Wnioski skonfrontowano z wybranymi instytucjami prawa cywilnego w celu wykazania, jak prawo i orzecznictwo postrzegają różne formy kłamstwa, występujące na gruncie prawa pozytywnego.
Evaluation of an Early Language and Literacy Program for Parents of Infants in the NICU
Authors: Shanty Lisa , Dowling Rebecca , Sonnenschein Susan , Hussey-Gardner Brenda
Published: July 2019

Purpose

To evaluate the effect of a NICU parent education program on parents' early language and literacy practices, and on their confidence interpreting and responding to infant signals.

Design

Single group, pre- and post-test, mixed-methods evaluation design.

Sample

One hundred and four parents and other caregivers completed questionnaires before and after the one-hour program. Ten parents participated in follow-up interviews.

Main Outcome Variables

Before and after sessions, participants reported on frequency of their current and intended early language and literacy practices, and their confidence interpreting and responding to infant signals. Participants also reported program satisfaction. Interview participants reported their behavior change one to two weeks later.

Results

The program significantly increased intention to engage in more early language and literacy practices, and increased parent-reported knowledge of how and when to interact with their infants. The majority of interviewed parents reported engaging in these practices one to two weeks later.
About Face: Toward a Culture of Innovation
Authors: Jnah Amy J.
Published: July 2019

Intellectual curiosity is the gateway to an innovative mindset. Success is contingent upon what we do with that knowledge to solve problems in our everyday professional practices. However, merely 13 to 25 percent of college graduates enter the workforce with the desirable innovative mindset. Rather, a culture of mediocrity persists within facets of academia as well as the professional workforce. Given that the youngest ranks of nurses emerge from institutes of higher learning and are the future of the nursing workforce, it is appropriate for academia to begin the charge toward change. This article presents a pragmatic discussion of key antagonists to the adoption of a culture of innovation, namely factors that comprise a culture of mediocrity. Strategies that promote creative problem-solving and a shift toward a collaborative culture of innovation will be presented for nurses practicing within academia and the health care system.
Exposure and Response Prevention for Postpartum Obsessive-Compulsive Disorder
Authors: Gershkovich Marina
Published: July 2019

Pregnancy and postpartum periods are associated with increased risk for onset and exacerbation of obsessive-compulsive disorder (OCD) symptoms. Common themes of the obsessive thoughts in this period are fears of accidently or intentionally harming the baby. Postpartum OCD may go underdiagnosed or misdiagnosed due to lack of standardized screening and potential shame associated with reporting these symptoms. Without treatment, OCD symptoms often persist and continue to impair mother's quality of life and interactions with the child. Literature on treatment specific to postpartum OCD is limited to case series and small studies. Exposure and response prevention (ERP), a gold-standard treatment for OCD, seems to be effective for this particular manifestation of OCD. This article presents a case history and ERP treatment course for a patient presenting with sudden onset of OCD following the birth of her child. Key differential diagnostic features, specific treatment strategies, and practice points are also explored.
Using Cognitive-Behavioral Therapy to Treat Obsessive-Compulsive Disorder With Co-Occurring Depression
Authors: Wheaton Michael G. , Gallina Epifania Rita
Published: July 2019

Many individuals with obsessive-compulsive disorder (OCD) also experience co-occurring depression, which may complicate OCD treatment. Some data suggest that OCD patients with comorbid depression experience less improvement with cognitive-behavioral therapy (CBT), the recommended psychotherapy for OCD. In particular, depression may interfere with an individual's adherence to the tasks of CBT, particularly exposure and response prevention (ERP). However, successful interventions exist for depression within CBT, including both cognitive therapy and behavioral activation, which can be added in treating OCD patients with depression. This article reviews the literature on the impact of comorbid depression on OCD treatment and then describes the treatment of an adult with both conditions. This case history demonstrates how depression-specific interventions can be incorporated into standard ERP to maximize OCD treatment gains. We also review important practice points for treating clinicians and areas for future research.
Using an Acceptance and Commitment Therapy Approach When Exposure and Cognitive Therapy Become Rituals in the Treatment of Obsessive-Compulsive Disorder
Authors: Buchholz Jennifer L. , Abramowitz Jonathan
Published: July 2019

Exposure and response prevention (ERP) for obsessive-compulsive disorder (OCD) is often highly effective, yet some patients experience relapses following a seemingly successful course of treatment. In this article we describe the conceptual basis of ERP, and then present a client who relapsed after seemingly achieving substantial improvement following 11 sessions of ERP. Likely reasons for the relapse and strategies for enhancing ERP to achieve better long-term treatment outcomes are discussed from the perspective of acceptance and commitment therapy (ACT). These strategies mainly apply to the implementation of situational (in vivo) and imaginal exposure therapy, but also include suggestions for optimizing the use of cognitive therapy for OCD.
Continuing Education Module—Information Needs and Information-Seeking Processes of Low-Income Pregnant Women in Relation to Digital Maternity Education Resources
Authors: Arcia Adriana , Stonbraker Samantha , Warner Eva Rose Asaan
Published: July 2019

Pregnant women need high-quality, timely information for self-management. The extent to which digital education resources meet their needs is unclear. This study elucidated how low-income pregnant women characterize their digital information needs and seeking processes and identified barriers/facilitators to meeting them. Focus groups bookending field-testing of a digital maternity education resource elicited barriers to and facilitators of Internet access, Internet use patterns, preferred methods to access information, and explored acceptability and desired features of online resources. Content analysis was used to analyze transcripts and six thematic categories were identified. Digital maternity education resources should be flexible, easily shared with loved ones, and responsive to users' experiences. Although helpful, digital resources are insufficient to meet pregnant women's need for social support.
LA OCASIÓN COMO ELEMENTO ESCENCIAL DEL ACCIDENTE DE TRABAJO EN ITALIA Y SU ENFOQUE JURIDICO-LEGAL EN SUDAMÉRICA
Authors: Valentino Irving Aldo Rojas
Published: July 2019

El presente artículo nos brinda un alcance mayor respecto a la ocasión como requisito fundamental en la defnición y determinación del accidente de trabajo, su desarrollo histórico y su defnición actual en Italia y en parte de Europa; partiendo de los parámetros dictados por la doctrina civilista, su concepción en los primeros años dentro del seguro social y su redefnición junto al mayor alcance que viene teniendo el riesgo profesional como objeto de la tutela del seguro en referencia. Así también se da una percepción de como el concepto de ocasión de trabajo viene siendo considerado em Sudamérica, tanto a nivel legislativo como jurisdiccional y su impacto en lo social.
A EXPANSIVA HERMENÊUTICA CONSTITUCIONAL COMO MOTE DO ATIVISMO JUDICIAL
Authors: Souza Junior Arthur Bezerra de , Jarnyk Ronaldo de Oliveira
Published: July 2019

Na intenção de promover direitos expressos na carta constitucional, o Poder Judiciário, mais precisamente o Supremo Tribunal Federal, ante a omissão dos outros poderes, atua de forma altiva no sentido de responder à sociedade os anseios por todas as garantias entregues pela Lei Maior. Empossado na função de Guardião da Constituição, o STF busca a concretização dos preceitos constitucionais, extrapolando, por vezes, sua função típica. O presente trabalho tem por fnalidade analisar o Ativismo Judicial diante do posicionamento da Suprema Corte, embasada em uma forma de interpretação, que é a hermenêutica expansiva.
DIREITO AO SOSSEGO
Authors: Viotti Juliana Kairalla Garcia , Sahyoun Najla Pinterich
Published: July 2019

O direito ao sossego é um direito que qualquer pessoa tem de gozar de tranquilidade, silêncio e repouso necessários para manutenção de sua saúde, sem que haja perturbações sonoras abusivas. Consiste, portanto, em um direito da personalidade, que visa assegurar o direito à vida e à saúde. O presente trabalho tem como escopo analisar o tratamento dado a referido direito na esfera constitucional e os reﬂexos dessa proteção nas esferas cível e criminal, na legislação pátria e em alguns ordenamentos estrangeiros.
POLÍCIA DE PROXIMIDADE E O PROJETO “SOU ESTUDANTE, SOU CIDADÃO”: UMA ANÁLISE ACERCA DOS RESULTADOS PROMOVIDOS PELA POLÍCIA MILITAR DE CAMBORIÚ/SC
Authors: Régis Jonathan Cardoso , Ghilardi Thiago Teixeira
Published: July 2019

O presente trabalho foi desenvolvido com o objetivo de analisar, mesmo que num curto espaço de tempo quando da implementação do Projeto "Sou Estudante, Sou Cidadão", implementado no Bairro Monte Alegre, no município de Camboriú/SC, através da 1ª Companhia do 12º Batalhão de Polícia Militar, e seus reflexos, decorrente das ações preventivas, calcadas pela polícia de proximidade, na observância ao princípio universal da dignidade da pessoa humana, aliada a doutrina de proteção integral disposta constitucional e infraconstitucionalmente no ordenamento jurídico brasileiro, através da concretização de políticas públicas efetivas e num trabalho de parceria, em especial, entre a Polícia Militar local e a comunidade escolar. A premissa do projeto findou-se na quebra de paradigma quanto as ações de polícia de proximidade no ambiente escolar, por parte da Polícia Militar e estudantes do ensino fundamental que encontram-se, na grande maioria, inseridas em um contexto/realidade de vitimização ou direta/indiretamente sondadas pela marginalidade, por conta da vulnerabilidade social daquela comunidade. Para uma melhor compreensão da matéria, estudou-se a dignidade da pessoa humana como tutela constitucional das pessoas em desenvolvimento, transpassando pelas políticas públicas tuteladoras e garantidoras da proteção integral e, finalizando quanto uma análise dos resultados decorrentes do já referenciado projeto.
O DEVIDO PROCESSO LEGAL SUBSTANCIAL E SUA APLICAÇÃO AO INQUÉRITO POLICIAL
Authors: Pereira André Luiz Bermudez
Published: July 2019

O presente trabalho tem por fnalidade estudar a relação do mais tradicional instrumento de investigação criminal, o Inquérito Policial, com a cláusula do devido processo legal substancial. O Código de Processo Penal brasileiro disciplinou a investigação preliminar do artigo 4º ao artigo 23, conferindo inúmeras características ao referido procedimento extrajudicial. Todavia, importante destacar que, à exceção do parágrafo único do art. 20 do citado diploma normativo, os dispositivos citados não foram alterados desde a edição do Decreto Lei que instituiu o Código de Processo Penal, ou seja, sem alteração desde 03 de outubro 1941. Assim, faz-se necessário revisitar os dispositivos supramencionados a fm de proceder à fltragem constitucional, mormente em face do princípio do devido processo legal substancial, trazendo à discussão elementos tradicionalmente elencados pela doutrina, sob a ótica de um processo penal democrático.
Raba krmišč pri navadnem muflonu (Ovis orientalis musimon) na Gorenjskem
Authors: Marenk Žiga , Krofel Miha
Published: July 2019

Mouflon (Ovis orientalis musimon) is currently the most abundant but poorly studied introduced ungulate species in Slovenia. Studies are rare also elsewhere across Europe, especially in respect to the use of artificial feeding sites, although supplemental feeding is common practice in many countries. We used camera-traps to determine group structure of mouflons using five winter feeding sites in the Gorenjska region (Julian Alps, NW Slovenia). We also studied their circadian activity and the use of mouflon feeding sites by other species. Average group size was 3.5 animals and feeding sites were most often used by ewes with their offspring. We recorded two peaks in circadian use of feeding sites at sunrise and sunset. We recorded six other species using the feeding sites, red deer (Cervus elaphus) being the most dominant among them. Use of camera-traps at the artificial feeding sites proved to be an efficient method to monitor mouflon population and their use of feeding sites.
Patterns of tree microhabitats across a gradient of managed to old-growth conditions
Authors: Sever Kristina , Nagel Thomas A.
Published: July 2019

An inventory of tree microhabitats was done in two unmanaged forests (Kobile and Ravna gora forest reserves) and one managed beech forest in SE Slovenia. The purpose of this study was to determine the influence of forest management, natural disturbances, and tree characteristics on microhabitat patterns. Forest structure and microhabitats were recorded in systematically placed plots (500 m2 in size) across each area. In total, we inventoried 849 trees on 54 plots and 1833 tree microhabitats. The results showed that forest management had no significant influence on the abundance of microhabitats per tree, but there were differences regarding microhabitat type between managed and unmanaged sites. There were substantially more microhabitats related to standing dead and live habitat trees in unmanaged forest (e.g. woodpecker cavities, insect galleries and bore holes, branch holes, dead branches and fruiting bodies of fungi), whereas in managed forests there were more tree microhabitats related to management (e.g. exposed heartwood, coarse bark, and epiphytic plants). The results also indicate that disturbance, tree diameter, vitality, and species influence the density, diversity, and occurrence of tree microhabitats.
JUAL BELI BITCOIN DI INDODAX.COM. DALAM PERSPEKTIF SYARIAH
Authors: Aufima Zidna
Published: July 2019

AbstractThe use of bitcoin as a currency or payment instrument is prohibited by Indonesian Bank. However, bitcoin as an object of sell buy in the form of digital assets or intangible goods is traded on indodax.com. The method used is statute approach and conceptual approach. The results of this study can be known that the law of sell buy bitcoin on indodax.com in the perspective of sharia is forbidden because in fiqh, the contract of sell buy bitcoin on indodax.com. include fasid contract because bitcoin contains elements gharar, maysir, syubhat, and dharar as an object of sell buy so as to violate the provisions of sharia. Indonesian Ulema Council should issue National Sharia Board About Bitcoin. Keywords : Sell Buy, Bitcoin, Digital Assets, Indodax.com, The Perspective of Sharia                                  AbstrakPenggunaan bitcoin sebagai mata uang atau alat pembayaran dilarang oleh Bank Indonesia. Namun, bitcoin sebagai obyek jual beli yang berbentuk aset digital atau barang tidak berwujud diperjualbelikan di indodax.com. Metode yang digunakan adalah statute approach dan conceptual approach. Hasil penelitian ini dapat diketahui bahwa hukum jual beli bitcoin di indodax.com dalam perspektif syariah adalah dilarang karena dalam fikih, akad jual beli bitcoin di indodax.com. termasuk akad yang fasid karena bitcoin mengandung unsur gharar, maysir, syubhat, dan dharar sebagai obyek jual beli sehingga melanggar ketentuan syariah. Seharusnya Majelis Ulama Indonesia (MUI) mengeluarkan Fatwa Dewan Syariah Nasional (DSN) tentang Bitcoin. Kata Kunci : Jual Beli, Bitcoin, Aset Digital, Indodax.com, Perspektif Syariah.
The Contribution of Texture Contrasts and Combinations to Food Acceptance Across Cultures
Authors: Pellegrino Robert , Cheon Bobby , Forde Ciaran , Oleszkiewicz Anna , Pieniak Michal , Luckett Curtis
Published: July 2019

Texture has long been considered an important attribute for food acceptance. However, which specific textural characteristics contribute to overall acceptance of a food is not well understood. It has been suggested that texture contrasts and combinations are a universal feature in giving foods a desirable texture, yet this notion is largely based upon anecdotal data. This study uses multiple survey research methods to assess the importance of texture contrast and combinations across cultures (Poland, U.S.A., and Singapore). Participants (n = 288) completed a survey that included overt measures of food texture contrast importance as well as free response questions regarding texture. The overall importance of texture for food liking was not different across the populations. However, the participants from Singapore and Poland gave more importance to a desirable food having multiple textures than the U.S.A. cohort. When looking at free responses, participants were twice as likely to mention combinations (multiple textures) with a texture contrast when describing foods they liked, in comparison to foods they disliked. This was observed across all 3 cultures. However, the type and quantity of texture terms used within combinations were different among cultures. For instance, Asians enjoyed more texturally diverse food combinations than the other two cultures. These findings highlight the importance of texture contrasts and combinations in three distinct cultures.
Computational Algebraic Geometry and Quantum Mechanics: An Initiative toward Post-Contemporary Quantum Chemistry
Authors: Kikuchi Ichio , Kikuchi Akihito
Published: July 2019

A new framework in quantum chemistry has been proposed recently (``An approach to first principles electronic structure calculation by symbolic-numeric computation'' by A. Kikuchi). It is based on the modern technique of computational algebraic geometry, viz. the symbolic computation of polynomial systems. Although this framework belongs to molecular orbital theory, it fully adopts the symbolic method. The analytic integrals in the secular equations are approximated by the polynomials. The indeterminate variables of polynomials represent the wave-functions and other parameters for the optimization, such as atomic positions and contraction coefficients of atomic orbitals. Then the symbolic computation digests and decomposes the polynomials into a tame form of the set of equations, to which numerical computations are easily applied. The key technique is Gr\"obner basis theory, by which one can investigate the electronic structure by unraveling the entangled relations of the involved variables. In this article, at first, we demonstrate the featured result of this new theory. Next, we expound the mathematical basics concerning computational algebraic geometry, which are necessitated in our study. We will see how highly abstract ideas of polynomial algebra would be applied to the solution of the definite problems in quantum mechanics. We solve simple problems in ``quantum chemistry in algebraic variety'' by means of algebraic approach. Finally, we review several topics related to polynomial computation, whereby we shall have an outlook for the future direction of the research.
The Effects of Hot Deformation Parameters on the Size of Dynamically Recrystallised Austenite Grains of HSLA Steel
Authors: Gnapowski Sebastian , Kalinowska- Ozgowicz Elżbieta , Sniadkowski Mariusz , Pietraszek Aleksandra
Published: July 2019

This paper presents the results of investigations of the effects of hot deformation parameters in compression investigation on the austenite grain size in HSLA steel (0.16% C, 0.037% Nb, 0.004% Ti, 0.0098% N). The axisymmetric compression investigations were performed on cylindrical investigation specimens of d=1.2 using the Gleeble 3800 simulator. The strain rate=1s-1÷15.9s-1 and strain degree ε=1.2. Before deformation, the research specimens were austenitized at TA = 1100 ÷ 1250 °C. Metallographic observations of the primary austenite grains were conducted with an optical microscope, while the structure of dynamically recrystallized austenite, inherited by martensite, was examined by EBSD technique using a scanning electron microscope. Based on the analysis of investigation results, it was found that the size of dynamically recrystallized austenite grains in HSLA steel were clearly affected by hot compression parameters. In contrast, no significant impact of austenitising temperature on their size was found.
Plasma MicroRNAs Can be a Potential Diagnostic Biomarker for Endometriosis
Authors: Zhuo Zhihong , Wang Chuhan , Li Gao , Yu Huimin
Published: July 2019

Plasma microRNAs are considered to be potential diagnostic biomarkers for endometriosis. Increasing evidence has shown that a huge amount of miRNAs are abnormally expressed in endometriosis plasma and play irreplaceable roles in diagnosis. The aim of the our study was to identify the differential expression of circular miRNA by reviewing the PubMed, ScienceDirect, and Cochrane databases between normal women and women with endometriosis and analyzing the miRNA data downloaded from the GEO database. Because of the differential miRNA expression in this review, we evaluated the diagnostic values of the differentially expressed miRNAs, particularly during the menstrual phases. According to the cut-off criteria with |log 2 FC|>1.0 and P < 0.05, 36 differentially expressed miRNAs were identified, including 13 upregulated miRNAs and 23 downregulated miRNAs. We developed miR-155, miR-574, miR-23a, and miR-520d via a Venn diagram. Functional enrichment analysis considered that the target miRNAs might be involved in various pathways related to endometriosis, including neurotrophin, Hippo, oocyte meiosis, ubiquitin mediated proteolysis, HTLV-Infection, FoxO, and Rap1 signaling pathways. CTNNB1, MYC, and ES R1 of transcription factors were related to the differentially expressed miRNAs. In summary, our study suggested that a four-miRNA could be included as a prognostic marker in endometriosis.
Effect Balance of Bokashi and Inorganic Fertilizer on Growth, Simplicia Yield, and Content Of Sinensetin of Kumis Kucing (Orthosiphon aristatus (Blume) Miq.)
Authors: Adiarti Yoviana Erdhika , Pujiasmanto Bambang , Dewi Widyatmani Sih
Published: July 2019

Growth potential, simplicia yields, and secondary metabolites of sinensetin varieties kumis kucing can be increased through fertilization management. The aim of this research was to examine the effect balance of bokashi and inorganic fertilizer on growth, simplicia yields and secondary metabolites of sinensetin kumis kucing varieties. The design of research was a split-plot field experiment, with the main plot were varieties (Orsina 1 and Orsina 2) and subplots in bokashi fertilization of goat manure (control, bokashi 15 tons ha-1, bokashi 15 tons ha-1 + 100% inorganic fertilizer dose recommendation, bokashi 15 tons ha-1 + 50% recommended dosage of inorganic fertilizer and 100% recommended inorganic fertilizer). Inorganic fertilizer recommendations consist of Urea 100 kg ha-1, SP36 200 kg ha-1, and KCl 100 kg ha-1. The results showed that the use of bokashi 15 tons ha-1 + 50% inorganic fertilizer increased growth. Besides it also produced the highest simplicia of 48.57 g plant-1 and the highest secondary metabolite of 0.045% plant-1 in Orsina 1. Both kumis kucing varieties did not show growth differences and yields. Bokashi fertilizer can reduce the use of inorganic fertilizers in the growth and simplicia yields and potentially increase sinensetin of kumis kucing.
Abiotic Stress And Biofertilizer on The Pereskia bleo (Kunth) DC. Against Growth, Proline, and Antioxidants
Authors: Dullah Intan Christin , Sulandjari Sulandjari , Supriyono Supriyono
Published: July 2019

Pereskia bleo is a spiny bush from the genus Pereskia and family Cactaceae. Its leaves are shiny green, flowering, and fruitful. Some researchers to indicate that P.bleo leaves contain high antioxidants, anti-cancer, and are traditionally used for diabetic, hemorrhoids, hypertension, and gastric pain. The aim of this study was to determine the effect of salinity stress and water volume as well as the role of biofertilizer on the growth of Pereskia bleo and antioxidant content. Using Nested design (completely randomized factorial) with NaCl treatment; 0 ppm, 5 ppm, 10 ppm, and biofertilizer; 5 ppm, 10 ppm, each nested in a water volume of 500 ml, 300 ml and 150 ml per polybag. Each treatment was repeated three times, resulting in a total sample of 54 plants. Meanwhile, the findings indicate that abiotic pressure suppresses growth and proline, but not on antioxidants. There is an interaction between salinity and biofertilizer against antioxidants. Abiotic Stress can increase the antioxidant content.
Physiology and Biochemistry of Fe Excess in Acidic Asian Soils on Crop Plants
Authors: Dey Sangita , Kar Saradia , Regon Preetom , Panda Sanjib Kumar
Published: July 2019

Proper transport of iron is very crucial for plant growth and development as it participates in various complex processes in plants like absorption, translocation etc. It also acts as an important component for processes like photosynthesis and respiratory electron transport chain in mitochondria, chloroplast development, and chlorophyll biosynthesis. Asian soils suffer from iron toxic condition and that adversely affects the growth and yield of the plant. This review describes the importance of iron in plant growth and different strategies adopted by plants for iron uptake. It also focuses on different methods and approaches on how plant can cope against acidic soils.