bluuebunny/crossref_metadata_2025 huggingface dataset:
Undiagnosed cardiovascular risk factors including elevated lipoprotein(a) in patients with ischaemic heart disease
Authors: Chua Fionn , Lam Audrey , Mak Ying Hui , Lee Zhong Hui , Dacay Lily Mae , Yew Jie Lin , Puar Troy , Khoo Joan , Chow Weien , Tan Vern Hsen , Tong Khim Leng , Liew Boon Wah , Yeo Colin , Loh Wann Jia
Published: July 2023

Objectives

This study aims to investigate the prevalence of undiagnosed cardiovascular risk factors in patients with ischaemic heart disease (IHD).

Methods

We assessed the prevalence of previously undiagnosed cardiovascular risk factors, including elevated lipoprotein(a) [Lp(a)], among consenting patients with IHD who were admitted to hospital. Clinical information, including dietary history, from patients with newly diagnosed IHD and known IHD were compared.

Results

Of the 555 patients, 82.3% were males and 48.5% of Chinese ethnicity. Overall, 13.3% were newly diagnosed with hypertension, 14.8% with hypercholesterolemia, and 5% with type 2 diabetes (T2DM). Patients with newly diagnosed IHD, compared to those with known IHD, had a higher prevalence of new diagnoses of hypercholesterolemia (29.1% vs. 2.0%, p < 0.001), hypertension (24.5% vs. 3.4%, p < 0.001) and T2DM (7.3% vs. 3.1%, p = 0.023). Active smoking was prevalent in 28.3% of patients, and higher in newly diagnosed IHD (34.1% vs. 23.2%, p = 0.005). Elevated Lp(a) of ≥120 nmol/L was detected in 15.6% of all patients, none of whom were previously diagnosed. Dietary habits of >50% of patients in both groups did not meet national recommendations for fruits, vegetables, wholegrain and oily fish intake. However, patients with known IHD had a more regular omega-3 supplement intake (23.4% vs. 10.3%, p = 0.024).

Conclusion

Increased detection efforts is necessary to diagnose chronic metabolic diseases (hypertension, hypercholesterolemia, T2DM) especially among patients at high risk for IHD. Cardiovascular risk factors, in particular elevated Lp(a), smoking, and suboptimal dietary intake in patients with IHD deserve further attention.
Associations of lipids and lipid-lowering drugs with risk of stroke: a Mendelian randomization study
Authors: Qin Hao , Yang Fan , Zhao Haitao , Zhao Jinchuan , Lin Siyuan , Shang Yinshuai , Zhang Chaoling , Hao Pengfei , Zhang Xianfeng
Published: July 2023

Background

Stroke is a leading cause of death worldwide, but it is unclear whether circulating lipids and lipid-lowering drugs are causally associated with stroke and its subtypes.

Methods

We used two-sample Mendelian randomization (MR) to examine the effects of blood lipids and lipid-lowering drugs on stroke and its subtypes.

Results

The inverse variance weighted Mendelian randomization (IVW-MR) revealed the low-density lipoprotein cholesterol (LDL-C) (OR, 1.46; 95% CI, 1.17–1.83; p = 0.0008) and apolipoprotein B (apoB) (OR, 1.46; 95% CI, 1.21–1.77; p = 0.0001) was positively correlated with large artery stroke (LAS). However, no causal effect was found in LDL-C and apoB on LAS risk when we conducted mvMR. The IVW-MR also found a suggestive evidence that decreased LDL-C levels mediated by the PCSK9 (proprotein convertase subtilisin-kexin type 9) gene were associated with a reduced risk of any stroke (AS) (OR, 1.31; 95% CI, 1.13–1.52; p = 0.0003), any ischemic stroke (AIS) (OR, 1.29; 95% CI, 1.10–1.51; p = 0.001), and LAS (OR, 1.73; 95% CI, 1.15–2.59; p = 0.008), while NPC1L1 (Niemann-Pick C1-like protein)-mediated LDL-C levels were associated with a higher risk of small vessel stroke (SVS) (OR, 6.10; 95% CI, 2.13–17.43; p = 0.0008). The SMR revealed that expression of PCSK9 was associated with risk of AS (OR, 1.15; 95% CI, 1.03–1.28; p = 0.01), AIS (OR, 1.02; 95% CI, 1.14–1.29; p = 0.03), cardioembolic stroke (CES) (OR, 1.28; 95% CI, 1.01–1.61; p = 0.04). And, a significant association was found between the expression of NPC1L1 and the risk of SVS (OR, 1.15; 95% CI, 1.00–1.32; p = 0.04).

Conclusion

We cautiously find that LDL-C and apoB was positively correlated with LAS. These findings suggest that the reducing LDL-C levels could be an effective prevention strategy for reducing the risk of stroke.
Recent progress on the detection of animal-derived food stimulants using mass spectrometry-based techniques
Authors: Zhang Qiang , Du Hongying , Zhang Yingjian
Published: July 2023

Background

The misuse of animal-derived stimulants in food is becoming increasingly common, and mass spectrometry (MS) is used extensively for their detection and analysis. There is a growing demand for abused-substances detection, highlighting the need for systematic studies on the advantages of MS-based methods in detecting animal-derived stimulants.

Objective

We reviewed the application of chromatography-mass spectrometry to the screening and detection of food stimulants of animal origin. Specifically, we analyzed four common animal sources of synthetic steroids, β-receptor agonists, zearalenol (ZAL), and glucocorticoids. We also explored the potential of using chromatography-mass spectrometry to detect and analyze animal-derived foods.

Methods

We searched and screened the Web of Science and Google Scholar databases until April 2023. Our inclusion criteria included a publication year within the last 5 years, publication language of English, and the research fields of food analysis, environmental chemistry, and polymer science. Our keywords were “mass spectrometry,” “anabolic androgenic steroids,” “β-2agonists,” “glucocorticoids,” “zearalenone,” and “doping.”

Results

Although traditional techniques such as thin-layer chromatography and enzyme-linked immunoassays are simple, fast, and suitable for the initial screening of bulk products, they are limited by their relatively high detection limits. Among the methods based on MS, gas chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry are the most widely used for detecting food doping agents of animal origin. However, a sensitive method with high repeatability and a short analysis time for a large number of samples is still required. Advances in MS have enabled the detection of extremely low concentrations of these substances. Combining different techniques, such as high-resolution mass spectrometry, ultra-high performance liquid chromatography–tandem mass spectrometry, gas chromatography-combustion-isotope ratio mass spectrometry, ultra-high performance liquid chromatography-high resolution mass spectrometry, and two-dimensional chromatography, offers significant advantages for detecting trace illicit drugs in animal-derived foods. Due to advances in assay technology and sample preparation methods, sample collection and storage methods such as dried blood spots, dried urine spots, and volumetric absorptive microsampling are increasingly accepted because of their increased stability and cost-effectiveness.

Significance

MS significantly improves the efficiency of detecting doping agents of animal origin. With the continuous development of MS technology, its application in the fields of doping detection and the analysis of doping agents of animal origin is expected to become more extensive.
Fractal dimension: analyzing its potential as a neuroimaging biomarker for brain tumor diagnosis using machine learning
Authors: Battalapalli Dheerendranath , Vidyadharan Sreejith , Prabhakar Rao B. V. V. S. N. , Yogeeswari P. , Kesavadas C. , Rajagopalan Venkateswaran
Published: July 2023

Purpose: The main purpose of this study was to comprehensively investigate the potential of fractal dimension (FD) measures in discriminating brain gliomas into low-grade glioma (LGG) and high-grade glioma (HGG) by examining tumor constituents and non-tumorous gray matter (GM) and white matter (WM) regions.

Methods: Retrospective magnetic resonance imaging (MRI) data of 42 glioma patients (LGG, n = 27 and HGG, n = 15) were used in this study. Using MRI, we calculated different FD measures based on the general structure, boundary, and skeleton aspects of the tumorous and non-tumorous brain GM and WM regions. Texture features, namely, angular second moment, contrast, inverse difference moment, correlation, and entropy, were also measured in the tumorous and non-tumorous regions. The efficacy of FD features was assessed by comparing them with texture features. Statistical inference and machine learning approaches were used on the aforementioned measures to distinguish LGG and HGG patients.

Results: FD measures from tumorous and non-tumorous regions were able to distinguish LGG and HGG patients. Among the 15 different FD measures, the general structure FD values of enhanced tumor regions yielded high accuracy (93%), sensitivity (97%), specificity (98%), and area under the receiver operating characteristic curve (AUC) score (98%). Non-tumorous GM skeleton FD values also yielded good accuracy (83.3%), sensitivity (100%), specificity (60%), and AUC score (80%) in classifying the tumor grades. These measures were also found to be significantly (p < 0.05) different between LGG and HGG patients. On the other hand, among the 25 texture features, enhanced tumor region features, namely, contrast, correlation, and entropy, revealed significant differences between LGG and HGG. In machine learning, the enhanced tumor region texture features yielded high accuracy, sensitivity, specificity, and AUC score.

Conclusion: A comparison between texture and FD features revealed that FD analysis on different aspects of the tumorous and non-tumorous components not only distinguished LGG and HGG patients with high statistical significance and classification accuracy but also provided better insights into glioma grade classification. Therefore, FD features can serve as potential neuroimaging biomarkers for glioma.
The experiences of autistic doctors: a cross-sectional study
Authors: Shaw Sebastian C. K. , Fossi Alexander , Carravallah Laura A. , Rabenstein Kai , Ross Wendy , Doherty Mary
Published: July 2023

Introduction

Medicine may select for autistic characteristics. As awareness and diagnosis of autism are growing, more medical students and doctors may be discovering they are autistic. No studies have explored the experiences of autistic doctors. This study aimed to fill that gap.

Methods

This is a cross-sectional study. A participatory approach was used to identify the need for the project and to modify a pre-existing survey for use exploring the experiences of autistic doctors.

Results

We received 225 responses. 64% had a formal diagnosis of autism. The mean age of receiving a formal diagnosis was 36 (range 3–61). Most were currently working as doctors (82%). The most common specialties were general practice / family medicine (31%), psychiatry (18%), and anesthesia (11%). Almost half of those working had completed specialty training (46%) and 40% were current trainees. 29% had not disclosed being autistic to anyone at work. 46% had requested adjustments in the workplace but of these, only half had them implemented.

Three quarters had considered suicide (77%), one quarter had attempted suicide (24%) and half had engaged in self-harm (49%). 80% reported having worked with another doctor they suspected was autistic, but only 22% reported having worked with another doctor they knew was autistic. Having never worked with a potentially autistic colleague was associated with having considered suicide.

Most preferred to be called “autistic doctors” (64%). Most considered autism to be a difference (83%). Considering autism to be a disorder was associated with preference for the term “doctors with autism,” and with having attempted suicide.

Conclusion

Autistic doctors reported many challenges in the workplace. This may have contributed to a culture of nondisclosure. Mental health was poor with high rates of suicidal ideation, self-harm, and prior suicide attempts. Despite inhospitable environments, most were persevering and working successfully. Viewing autism as a disorder was associated with prior suicide attempts and a preference for person-first language. A neurodiversity-affirmative approach to autism may lead to a more positive self-identity and improved mental health. Furthermore, providing adequate supports and improving awareness of autistic medical professionals may promote inclusion in the medical workforce.
Treatment outcomes among children admitted stabilization centers in Eastern Ethiopia: retrospective study
Authors: Ahmed Jemal Abrahim , Yusuf Newas , Wilfong Tara , Tukeni Kedir Negesso , Berhanu Hiwot , Roba Kedir Teji
Published: July 2023

Background

There is improved access to Sever Acute Malnutrition management in Ethiopia; however, studies have revealed an alarming rate of defaulters’ poor recovery and deaths, emphasizing the importance of researching to identify major causes. As a result, the goal of this research is to identify treatment outcome determinants and associated factors in severely malnourished children aged 6–59 months admitted to public hospitals in Eastern Ethiopia’s stabilization centers.

Methods

This study used an institutional-based retrospective cohort study design with 712 children aged 6 to 59 months. Data was gathered using a Sever Acute Malnutrition registration logbook and patient charts. Participants were chosen at random from their respective healthcare facilities based on population proportion. Epi-data was entered and analyzed using STATA version 14. To identify associated factors, the Cox proportional hazard Ratio was calculated, and a p-value of 0.05 at the 95% confidence interval was considered statistically significant.

Results

This study revealed that only 70.65% (95% CI = 67.19, 73.88) of the children were cured while 17.84% defaulted from the management and 5.90% died. Children who did not have tuberculosis (AHR = 1.58, 95%CI:1.04, 2.40), anemia (AHR = 1.31, 95% CI:1.03, 1.68), Kwash dermatosis (AHR = 1.41, 95%CI:1.04, 1.91), or on NG-tube (AHR = 1.71, 95%CI:1.41, 2.08) were more likely to be cured from SAM.

Conclusion

This study discovered that the cure rate is extremely low and the defaulter rate is extremely high. As a result, intervention modalities that address the identified factor are strongly recommended to accelerate the rate of recovery in Eastern Ethiopia.
Research on a Knowledge Graph Embedding Method Based on Improved Convolutional Neural Networks for Hydraulic Engineering
Authors: Liu Yang , Tian Jiayun , Liu Xuemei , Tao Tianran , Ren Zehong , Wang Xingzhi , Wang Yize
Published: July 2023

In response to the shortcomings of existing knowledge graph embedding strategies, such as weak feature interaction and latent knowledge representation, a unique hydraulic knowledge graph embedding method is suggested. The proposed method incorporates spatial position features into the entity-relation embedding process, thereby enhancing the representation capability of latent knowledge. Furthermore, it utilizes a multi-layer convolutional neural network to fuse features at different levels, effectively capturing more abundant semantic information. Additionally, the method employs multi-scale dilated convolution kernels to capture rich explicit interaction features across different scales of space. In this study, the effectiveness of the proposed model was validated on the link prediction task. Experimental results demonstrated that, compared to the ConvE model, the proposed model achieved a significant improvement of 14.8% in terms of mean reciprocal rank (MRR) on public datasets. Additionally, the suggested model outperformed the ConvR model on the hydraulic dataset, leading to a 10.1% increase in MRR. The results indicate that the proposed approach exhibits good applicability and performance in the task of hydraulic knowledge graph complementation. This suggests that the method has the potential to offer significant assistance for knowledge discovery and application research in the field of hydraulics.
SULTAN'S WISDOM IN PRESERVING CULTURE AS SUSTAINABLE TOURISM DEVELOPMENT
Authors: Handoko Tri Akbar , Arief Nuryana  , Mikhael Maestro Mastrivo Sebayang  , Afia Fauziah  , Ahmad Fatah Haidar Rahmat  , M. Baiquni
Published: July 2023

From the perspectives of economic, social, politics, and cultural preservation, the sultan's wisdom can have an impact on the entire ecosystem in the implementation of policies toward sustainable tourism destinations in the Jeron Beteng Region - Yogyakarta. The Jeron Beteng neighborhood, which is inside the palace fortress, is currently dealing with global phenomena like population growth, declining public service quality, decreasing availability of residential areas, traffic congestion, a lack of parking, rising levels of energy consumption, garbage buildup, and rising crime rates. As a result, the Jeron Beteng region can continue to be sustainable thanks to palace culture, which has been described by the sultan's knowledge in formulating policies, along with standards and principles for managing the quality of life.The Yogyakarta Palace, which is the de facto owner and authority of the land and the culture inside it, as well as other supporting papers are used in the research's descriptive qualitative methodologies to gather both primary and secondary data from government officials, community members, and other sources. The methods of gathering data include interviews, observation, and documentation. The study's findings demonstrate the sultan's wisdom toward environmentally friendly tourist attractions in Yogyakarta's Jeron Beteng district, which is deeply concerned with cultural preservation. However, the sultan's position is still crucial in encouraging people to adhere to legal requirements.
Global Seasonal-Scale Meteorological Droughts. Part I: Detection, Metrics, and Inland/Coastal Types
Authors: Liu Zhenchen , Zhou Wen
Published: July 2023

Knowledge of spatiotemporal characteristics and process evolutions is the fundamental basis of understanding drought mechanisms, especially from a global perspective. For a comprehensive investigation, we implemented event detection, type grouping, and spatiotemporal metrics from 3-dimensional (3D, longitude–latitude–time) perspectives. The major procedures and achievements were as follows. First, we identified global-scale seasonal-scale meteorological drought events following the recently proposed 3D DBSCAN (Density-Based Spatial Clustering of Applications with Noise)-based workflow of event detection. The 3D DBSCAN clustering algorithm can directly obtain arbitrarily shaped point collections over a given 3D space, as drought events can spread over space and evolve over time. Subsequently, these detected drought events are further grouped into inland and coastal types, as the observations revealed that some droughts over coastal regions originate from, extend to, or are accompanied by long-term precipitation deficits over adjacent oceans. Third, typical spatiotemporal characteristics (e.g., lifetime, genesis locations, migration/local developments, and process evolutions) were investigated with coastal/inland-type differences considered. The drought ratios originating from continents in all coastal-type droughts were ~50% over Africa, Asia, and South America, indicating the nonnegligible extension from continents to oceans. Additionally, process evolution-based analysis revealed intensity variations in intensification or recession phases, and coastal types overall displayed larger intensity variations than inland types. Moreover, ~92% of inland types and ~70% of coastal types can be treated as having symmetric development. Notably, the grouping type and spatiotemporal metrics herein can provide adequate preliminary knowledge for global-scale drought mechanism exploration.
THE IMPLEMENTATION OF BLOOM'S TAXONOMY IN CURRICULUM AND ASSESSMENT STANDARD DOCUMENT (DSKP) OF ISLAMIC EDUCATION IN SECONDARY SCHOOL: AN ANALYSIS
Authors: Azman Nor Alniza , Zulkifli Hafizhah , Tamuri Ab. Halim
Published: July 2023

Islamic Education teachers still do not fully understand the components found in Curriculum and Assessment Standard Document (DSKP). This shows that GPI less emphasize on the details of DSKP including the application of Bloom's Taxonomy from the cognitive, affective and psychomotor aspects. Therefore, this article aims to explain in detail the components found in the DSKP including the domains of Bloom's Taxonomy applied in the DSKP as well as analyse the appropriateness of Bloom's Taxonomy used in the Islamic Education DSKP in secondary schools. Based on content analysis from primary and secondary sources, the study found that there are 7 components in DSKP of Islamic Education besides 3 main domains of Bloom's Taxonomy which are cognitive, affective, and psychomotor that applied in the DSKP through content standards, learning standards and performance standards. The findings of the study also show that Bloom's Taxonomy is suitable for implementation in the DSKP of Middle School Islamic Education. However teachers need to be creative in adapting teaching and assessment methods according to the fields of Islamic Education. It is hoped that this article will be able to provide a comprehensive overview of secondary school Islamic Education DSKP as well as provide ideas to GPI in implementing Islamic Education teaching and learning by applying all components in DSKP. The implication of the study is to help GPI, especially novice teachers in understanding DSKP which is the main reference for teachers in the planning and implementation of teaching and learning.
Improving the efficiency of Sabatier reaction through H2O removal with low-pressure plasma catalysis
Authors: Hasegawa Taiki , Toko Susumu , Kamataki Kunihiro , Koga Kazunori , Shiratani Masaharu
Published: July 2023

This study aimed to realize in situ resource utilization in deep-space missions. The Sabatier reaction is used to generate CH4from CO2, which accounts for 95% of the Martian atmosphere, and H2from H2O on Mars. In general, thermal catalysis at temperatures above 250 °C drives the process. This high-temperature process, however, causes catalyst deactivation due to overheating. Plasma catalysis drives low-temperature reactions by excitation and decomposition of source gases via electron impact. We investigated the effect of removing H2O from gas phase in the reaction with Cu and Ni catalysts using molecular sieves in this study. The reverse reaction can be aided by OH radicals derived from H2O. Therefore, CO2conversion increased from 49.4% to 69.1% for Cu catalysts with molecular sieves, and CH4selectivity increased from 3.49% to 6.33%. These findings imply that removing H2O can suppress the reverse reactions.
Lattice strain visualization inside a 400 nm single grain of BaTiO3 in polycrystalline ceramics by Bragg coherent X-ray diffraction imaging
Authors: Oshime Norihiro , Ohwada Kenji , Machida Akihiko , Fukushima Nagise , Shirakawa Kosuke , Ueno Shintaro , Fujii Ichiro , Wada Satoshi , Sugawara Kento , Shimada Ayumu , Ueno Tetsuro , Watanuki Tetsu , Ishii Kenji , Toyokawa Hidenori , Momma Koichi , Kim Sangwook , Tsukada Shinya , Kuroiwa Yoshihiro
Published: July 2023

The degree of anisotropy and the domain arrangement of crystal structures in ferroelectrics are affected by the grain boundaries and by the shape and size of the grains. To understand the grain boundary effects that occur in ferroelectric ceramics, we introduce a technique for nondestructively observing the internal lattice strain distribution of a submicrometer-sized ferroelectric grain in polycrystalline materials. The ferroelectric phase transition of a single grain in the polycrystalline materials was evaluated by tracking the changes in the Bragg coherent X-ray diffraction (CXD) patterns. The internal lattice strain distribution of the grains in the paraelectric phase was visualized via Bragg CXD imaging. A pair of 90° domains in the ferroelectric phase were also imaged in three dimensions, and showed a domain boundary correlated with the internal lattice strain caused by the stresses from the adjacent grains.
PERAWATAN DIRI PADA ORANG DENGAN GANGGUAN JIWA (ODGJ) DI PUSAT REHABILITASI NARKOBA DAN GANGGUAN JIWA KABUPATEN BANYUASIN
Authors: Pastari Marta , Endriyani Sri , Martini Sri
Published: July 2023

Abstract

The Mitra Mulia Foundation is a Social and Independent Drug and Mental Disorder Rehabilitation Center located on Jalan Talang Buluh Dusun I RT.02 Kel. Talang Buluh, Kec. Talang Kelapa Kab. Banyuasin which is about 10 KM from the city center. Based on a preliminary study and permission to carry out activities carried out by the service team in May 2022, the problem was found; There is no self-care activity independently in the daily schedule of patients with hallucinations and as many as 10 out of 38 patients with hallucinations (26.3%) experience self-care deficits as evident from the inability to take care of personal hygiene, eat independently, decorate independently and toileting (defecation / urination). The solutions offered include; Education and accompaniment (Personal Hygiene Occupational Group Activity Therapy) for ODGJ with Hallucinations and Management at the Mitra Mulia Foundation as well as Redemonstration and Assistance (Personal Hygiene Occupational Activity Therapy) which was given to 10 patients with hallucinations (5 people/group) and 9 people managing the Mitra Mulia Foundation which was carried out during July-September 2022. Based on the achievement targets and results of activities, it can be concluded that; ODGJ with Hallucinations already has a routine activity schedule and includes self-care activities independently into the daily schedule; Reducing the incidence of self-care deficits in ODGJ with Hallucinations
PENINGKATAN MOTIVASI BELAJAR MAHASISWA MENGGUNAKAN METODE HYPNOMOTIVATION
Authors: Asmalinda Wita , Sapada Edy , Naue Dian Adhe Bianggo
Published: July 2023

Learning motivation is the driving or pulling force that causes a person's behavior towards a certain goal in order to have the will to act in learning. The hypnomotivation method is a learning method in conveying material, by exploring the subconscious, so that students become focused, relaxed and suggestive in accepting the subject matter provided. Alpha condition, it is possible to enter the material presented. The purpose of this activity is to increase student learning motivation during the Covid 19 pandemic using the hypnomotivation method. This community service activity uses training and mentoring methods with the main target being 42 first-level students of the Bachelor of Pharmacy study program. The training activities were carried out for 3 days, consisting of preparation, implementation and evaluation activities. It was concluded that training and mentoring using the hypnomotivation method ran smoothly and successfully and was able to increase student learning motivation.
ANALISIS KINERJA KEUANGAN DENGAN MENGGUNAKAN METODE CAMEL PADA PT. BPD KALTIM KALTARA PERIODE 2017-2021
Authors: Adis Adiska Nurul Khotimah , Ellyawati Noor , Sutrisno Sutrisno
Published: July 2023

Kinerja suatu perbankan dapat diketahui dari analisis laporan keuangan bank tersebut, masyarakat akan lebih mempercayakan dana yang mereka punya untuk dikelola oleh bank jika bank tersebut memiliki kinerja yang sehat dan baik. Penelitian ini bertujuan untuk mengetahui kinerja keuangan PT. BPD Kaltim Kaltara pada tahun 2017-2021 dengan menggunakan metode CAMEL. Jenis penelitian ini bersifat deskriptif analisis dengan pendekatan kuantitatif menggunakan data sekunder yang berupa data time series, rasio-rasio yang digunakan yaitu CAR (aspek Capital), KAP (aspek Asset), NPM (aspek Management), ROA dan BOPO (aspek Earning), serta LDR (aspek Liquidity). Hasil dari penelitian ini menunjukkan nilai akhir CAMEL pada tahun 2017 sebesar 92.5%, tahun 2018 sebesar 93.8%, tahun 2019 sebesar 92.54%, tahun 2020 sebesar 92.7%, dan tahun 2021 sebesar 92.3%. Semua hasil tersebut berada pada rentang angka 81%-100 sehingga dapat dinyatakan bahwa semua berada pada predikat sehat. Dengan demikian dapat disimpulkan bahwa kinerja keuangan pada PT. BPD Kaltim Kaltara Periode 2017-2021 dengan menggunakan metode CAMEL berada dalam predikat sehat
POJOK LITERASI BUDIDAYA TANAMAN UNTUK MASYARAKAT KOTO BARU NAN XX
Authors: Alatas Andi , Ananto Ananto , Sari Wilna , Jarlis Roni , Putri Santi Diana , Amelia Kiki , Migusnawati Migusnawati , Taufiqqurrahman Taufiqqurrahman
Published: July 2023

Tujuan dari kegiatan PkM ini yaitu mentransfer ilmu penegtahuan kepada masyarakat , yang dapat berguna bagi            kehidupan masyarakat, memberi motivasi kepada masyarakat, Sehingga Kegiatan pengabdian ini diharapkan dapat memperbaiki Sumber Daya Manuasia, menambah pendapatan keluargan dan meningkatkan kesejahteraan masyarakat. Kegiatan PkM ini dilaksanakan di pemukiman Perumahan Kelurahan Kotobaru Nan XX padang SUMBAR, dimana  kondisi di lingkungan perumahan memiliki keterbatasan lahan untuk melakukan proses budidaya tanaman, khususnya bagi pecinta tanaman hias maupun tanaman sayuran yang bisa menjadi kegiatan yang bisa menghasilkan luaran berupa tanaman maupun nilai estetika. Adapun strategi yang dipergunakan untuk mendukung realisasi program pengabdian masyarakat ini adalah dengan memberikan penyuluhan dan pelatihan. Hasil capaian PkM yaitu potensi untuk pengembangan budidaya tanaman sistim tabulampot sangat terbuka, mengingat lahan dan keadaan lingkungan memadai, dalam hal ini ternyata masyarakat banyak memiliki lahan kosong di pekarangan rumah untuk dapat dimanfaatkan secara maksimalserta antusiasisme warga sangat tinggi untuk melakukan teknik budidaya tanaman secara tabulampot.
ANALISA KANDUNGAN KADAR LOGAM BERAT PADA DAGING KEPITING (Scylla serrata) DI PERAIRAN MUARA SUNGAI BANYUASIN
Authors: Sandro Satria Rio , Lestari Susi , Purwiyanto Anna Ida Sunaryo
Published: July 2023

Heavy metal was a pollutant because its stable and difficult to disentangle. Heavy metals in the waters of Banyuasinâ€™s estuaries alleged negative impact on crabs and other aquatic animals. To see the impact research on the analysis of heavy metal content in the crab (Scylla serrata), in the territorial waters of Banyuasinâ€™s estuaries. The objective of this study was to determine the content of heavy metals (Pb, Cu and Fe) in the crab meat (Scylla serrata) in the territorial waters of Banyuasinâ€™s estuaries. Completely randomized design was used with 3 stations treatment and each station was repeated 3 times. Parameters observed were lead (Pb), copper (Cu) and iron (Fe).The results showed that the content of lead (Pb), copper (Cu) and iron (Fe) were different at each station.The highest content of lead (Pb) was on SI 0.0073 ppm and the highest content of copper (Cu) was on S-III 0.3713 ppm. The result indicates that still safe the crab (Scylla serrata) to consume based on national standards Pb 0,5 mg/kg and Cu 20 mg/kg . Iron content exceeds the standards set by the Department of Health in S-II at 2.054 ppm. Results of analysis of the iron content (Fe) on crab meat in consumption should be limited according to the established standards 2 mg/kg.
IMPLEMENTASI PROGRAM ADIWIYATA SEBAGAI SARANA PENANAMAN AKHLAK KEPADA ALAM PESERTA DIDIK DI SDN SOGAN
Authors: Annisa Dwi Wahyuni  , Henry Aditia Rigianti
Published: July 2023

Lingkungan berhubungan dengan perilaku manusia. Perilaku manusia yang sewenang-wenang dan tidak peduli terhadap lingkungan dapat menyebabkan kerusakan lingkungan. Pendidikan lingkungan di sekolah secara efektif dapat menumbuhkan perilaku peduli lingkungan pada masyarakat. Program adiwiyata merupakan program budaya sekolah yang dapat membentuk perilkau peduli lingkungan pada siswa. Tujuan penelitian ini yaitu untuk mengetahui implementasi program adiwiyata dan mendeskripsikan program adiwiyata sebagai sarana penanaman akhlak pada siswa di Sekolah Dasar Sogan. Metode penelitian yang digunakan adalah deskriptif kualitatif. Teknik pengumpulan data melalui wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa implementasi program adiwiyata di Sekolah Dasar Sogan menurut kriteria Kementerian Lingkungan Hidup yaitu kebijakan berwawasan lingkungan, penerapan kurikulum berbasis lingkungan, kegiatan lingkungan berbasis partisipatif, dan pengelolaan fasilitas penunjang yang ramah lingkungan telah dilaksanakan baik. Optimalisasi implementasi program adiwiyata mengajarkan siswa nilai-nilai kepedulian sehingga program adiwiyata banyak manfaatnya dan sangat sesuai dengan profil pelajar pancasila salah satunya adalah akhlak terhadap alam.
Whales for Sale: A Content Analysis of American Whale-Watching Operators’ Websites
Authors: Reamer Marcus , Macdonald Catherine , Wester Julia , Shriver-Rice Meryl
Published: July 2023

Digital media, particularly websites, have become a critical component of wildlife tourism experiences, especially during the pretour information-seeking stage. With a focus on whale watching, this study used a grounded theory approach to identify, categorize, and investigate the common
themes, text, and images used on 178 whale-watching operator websites across six geographic regions in the US. The results of a content analysis suggest that operators who are predominantly small business owners focus their marketing strategies on elements of their tour offerings and operator
characteristics to distinguish themselves from competitors rather than emphasizing the whales themselves, conservation actions, or educational opportunities, catering to a segment of entertainment-oriented rather than sustainability-oriented guests. Ecolabel-certified operators in the sample
mentioned conservation and educational topics more, though the information provided could still use improvement. We discuss implications and opportunities for the continued study of media related to whale watching and other marine wildlife tourism activities.
Regulatory Support and Institutions for the Transformation of Enterprises to the Digital Economy
Authors: Chorna O.А.
Published: July 2023

Regulatory support and institutions for the transformation of enterprises to the digital economy are considered. In particular, the basic institutions of the transformation of enterprises to the digital economy, inherent in any society: social (or socio-cultural), economic, political, were studied, and their structure was summarized. It is substantiated that it is the state that is entrusted with the task of ensuring the effective functioning of institutional and legal foundations and long-term development vectors of the country and enterprises in Ukraine. In the conditions of wartime and the development of the digital economy, it is necessary to create a structure of incentives and motivations for digitalization at the enterprises themselves.
The institutional and legal foundations of the digital transformation of enterprises by the institutions of state power are considered. The main legislative support for the formation and development of the digital economy in Ukraine is presented, the policy directions of the Ministry of Digital Transformation, its implementation of projects for the development of the digital economy, which create conditions for the development of business in Ukraine, the transformation of enterprises to new operating conditions, the development of human capital, and the preservation of labor potential are considered.
The impact of supranational institutions and European integration on the establishment of institutional and legal foundations for the transformation of enterprises to the digital economy is outlined. The main directions of Ukraine’s cooperation with the European Union in the development of the digital economy, which are among the priorities in cooperation, were considered.
Proposals regarding the improvement of institutions for the transformation of industrial enterprises to the digital economy are substantiated and relevant recommendations are provided. In particular, it was noted that Ukraine needs a modern industrial policy with defined principles and a vision. A strategy of industrial development is necessary, taking into account the digital economy, martial law, losses of industrial and labor potential, the need for post-war recovery and the adoption of the Law of Ukraine «On State Industrial Policy». The state industrial policy must meet the requirements of the times, therefore it should include the tasks of digital transformation of industrial enterprises and stimulating mechanisms of digital transformation.
Antibacterial Activity of the Halogen- and Nitro Derivatives of Benzimidazole Against Bacillus Subtilis
Authors: Begunov R. S. , Egorov D. O. , Chetvertakova A. V. , Savina L. I. , Zubishina A. A.
Published: July 2023

Background. Antibiotic resistance of bacteria is a serious concern for modern medicine. The search for new compounds with a pronounced antibacterial effect is an urgent task of pharmaceutical chemistry. The aim of the study was to assess nfluence of the structure of benzimidazole and its derivatives the ability to inhibit the growth of gram-positive bacteria Bacillus subtilis. Materials and methods. Antibacterial activity of diazaheterocycles was evaluated by the method of serial dilutions. Сoncentrations from 0,06 to 1000 µg/l were used. Тhe minimum inhibitory concentration (MIC) of benzimidazole derivatives against Bacillus subtilis BKM B-407 was determined. The antibacterial effect of the studied halogen- and nitrobenzimidazoles was compared with the antimicrobial activity of benzimidazole. Results. The antimicrobial activity of the 12 benzimidazole derivatives was established. 2-trifluoromethylbenzimidazoles containing halogen atoms in the phenylene fragment had the most pronounced inhibitory effect. The dihalogenated derivatives exhibited greater antibacterial activity than the compounds with one halogen atom in the benzene ring. 5,6-dibromo-2-(trifluoromethyl)benzimidazole was the most active compound with an MIC of 0.49 µg/mL, comparable to the commercial antibiotic tetracycline. The antibacterial activity of erythromycin is a half that of this substance. Conclusions. Polyhalogen derivatives of benzimidazole are promising compounds for the development of new antimicrobial drugs against Gram-positive bacteria.
Antibacterial Resistance. The Challenge of Modernity
Authors: Daudova A. D. , Demina Ju. Z. , Genatullina G. N. , Abdrakhmanova R. O. , Baeva G. R. , Yasenyavskaya A. L. , Rubalsky O. V.
Published: July 2023

Antimicrobial resistance is considered by WHO as one of the most important threats to public health in the twenty-first century. According to forecasts, by 2025, many first-line antimicrobials will lose their effectiveness and the «post-antibiotic era» will begin. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. and representatives of the genus Mycobacterium are classified by the American Society of Infectious Diseases as microorganisms that play a predominant role in the development of infections associated with medical care and leading to fatal consequences. The review highlights the mechanisms of antibiotic resistance and many variants of microbial resistance to antibiotics. Knowledge of the molecular mechanisms of the formation of resistance of microorganisms allows us to develop strategic directions for overcoming it. The search for new ways to prevent and overcome the formation of resistance of pathogens to antibiotics is an extremely important task of modern medical science. The effectiveness of hybrid antibiotics associated with chemical compounds with various specific effects is presented. The use of the main active factor of the bacterial virus, endolysin, both in its pure form and as part of homodimers, for example, lysoprotein, which is a complex of endolysin with human immunoglobulins, is considered promising. Phage therapy of the future is a personalized phage therapy that requires the creation of a library or bank of phages.
Analisis Penguasaan Konsep Fisika pada Materi Suhu dan Kalor Pasca Pembelajaran Online di Kelas XI SMA Negeri 12 Kota Kupang
Authors: Hara Alfani Kareri , Astiti Kadek Ayu , Lantik Vinsensius
Published: July 2023

Penelitian ini bertujuan untuk mengetahui bagaimana penguasaan konsep fisika pada materi suhu dan kalor. Penelitian ini dilakukan pada siswa kelas XI MIPA SMA Negeri 12 Kota Kupang. Jenis penelitiannya adalah deskriptif kuantitatif. Instrumen yang digunakan pada penelitian ini adalah tes diagnostik two-tier multiple choice dan wawancara. Sampel yang digunakan dalam penelitian ini adalah 20 orang siswa. Dalam penelitian ini, siswa mengerjakan soal tes diagnostik sebanyak 15 butir soal, hasil tes dikelompokkan sesuai kategori tingkat hasil penguasaan konsep, selanjutnya hasil tes dianalisis menggunakan teknik analisis statistik deskriptif. Berdasarkan hasil penelitian, terdapat 3 siswa pada kategori sangat rendah dengan persentase 15%, 6 peserta siswa pada kategori rendah dengan persentase 30%, 11 siswa berada pada kategori sedang dengan persentase 55%, dan kategori tinggi dan sangat tinggi dengan persentase 0%. Dengan demikian, penguasaan konsep fisika yang dimiliki oleh siswa dinyatakan berada pada kategori sedang dengan persentase 55%. Hal ini terjadi karena pembelajaran yang kurang efektif dan metode pembelajaran yang kurang sesuai dengan kebutuhan siswa pada pembelajaran online.
The Evaluation of the Final Stage of the Teaching Practice Program by the Students of the University of Western Macedonia
Authors: Pavlos Stavridis
Published: July 2023

Teaching practice is an integral part of the teachers’ education program met in every Department of Primary Education. Through this, prospective teachers acquire a wide range of experiences from their contact with school, both by observing and by conducting lessons, while they focus on the practical as well as the theoretical aspect of their studies. In the Department of Primary Education of Florina, teaching practice program is divided into three phases, initially in the form of observation (Phase I) and then with personal hourly teaching in the classroom (Phase II). Phase III is the conclusion of the teaching practice and aims at acquiring direct experience of the daily work and life at school, at developing prospective teachers’ ability to self-evaluate their work as well as at becoming aware of their pedagogical responsibility towards students through teaching a school class for about two weeks. This paper presents students' views on the extent to which the main objectives of Phase III are met, on how significant it is in guiding and supporting their work and on the difficulties, they have encountered in conducting it. This research approach is part of an on-site long-term research which examines the overall teaching practice program, using all prospective teachers (126) throughout their studies as a control group, and questionnaire and semi-structured interview as research tools, providing us with both quantitative and qualitative data. By analyzing the research data, we find that students: a) consider Phase III one of the most important parts of their practical training, b) acquire direct experience of everyday school life, c) develop the ability to reflect on and self-evaluate their work, d) design and prepare teaching under real working conditions, e) develop the ability to deal in a personalized way with children with particular teaching problems, while f) they encounter significant problems with the time-consuming process of preparing the next day's lesson plan.
The Perceived Relationship between Eco-friendly Business Practices and Firm Performance of SMEs in Vientiane Capital, Lao PDR
Authors: Inthakesone Bounmy , Sipaseuth Aliyamone , Syphoxay Pakaiphone
Published: July 2023

This study investigates the impact of environmental performance on firm profitability in Vientiane Capital, Lao PDR. Data from 419 firms were collected using an e-questionnaire distributed through a Google form. The results indicate a need to increase awareness and acknowledgment of clean activities among surveyed firms. While there is a positive trend towards energy-saving practices and the provision of designated smoking areas, more efforts are required to encourage the wider adoption of reusable practices and prioritize proper waste management. Regression analysis reveals significant impacts on firm profitability, with firms having regulations for environmentally friendly practices, acknowledging clean activities, providing free space for waste sorting or disposal, and having designated smoking areas experiencing notable increases in profitability. However, the impact of energy-saving policies on profitability is not significant, potentially due to insufficient implementation. The study recommends implementing and enforcing effective energy-saving policies, strengthening eco-friendly regulations, encouraging waste management and recycling practices, and catering to customer preferences to enhance firm financial performance. These measures can contribute to a more sustainable and environmentally responsible business landscape in Vientiane Capital, Lao PDR.
Multivariate Statistical Process Control and Classification Applied on Prostate Cancer Screening
Authors: Riis Oivind , Stensvold Andreas , Stene-Johansen Helge , Westad Frank
Published: July 2023

Introduction: We report in this study the results of analyzing biomarkers in blood samples with two objectives; i) as an approach for screening patients by use of Multivariate Statistical Process Control (MSPC); ii) Compare various classification methods with the purpose of diagnosing prostate cancer. Methods: We applied Principal Component Analysis (PCA) with statistical limits for outlier detection. Various splits of the data into training and test sets were chosen to evaluate the performance of classification methods as a function of the training/test sample ratio. Results: MSPC based on 12 analytes in blood samples was shown to outperform the traditional biomarker criterion: the level of the analyte Prostate-Specific Antigen (PSA), in screening for prostate cancer. The performance of different multivariate classification techniques for classifying which of the patients in a clinical pathway for prostate cancer have malignant tumors showed that the basic method Linear Discriminant Analysis (LDA) and classification trees gave similar results, whereas adaboost gave a higher specificity but lower sensitivity. Conclusion: The accuracy, especially the sensitivity, does not justify any clinical use of the applied classification methods with the available biomarkers. Additional medical information about the patients might enhance the accuracy with the purpose of identifying benign and malignant tumors.
Can a Kidney Failure Patient Survive with One to Two Hemodialysis Sessions per Month for More than 5 Years?
Authors: Ntabanganyimana Etienne , Nishimwe Theophile , Kyavulikira Benjamin , Nyandwi Eugene , Ntarindwa Joseph , Lloyd Vincent , Varughese Santosh
Published: July 2023

Background: Kidney failure known as renal failure or Stage 5 CKD or End Stage Renal Diseases is a major problem among kidney diseases worldwide, its incidence and prevalence are rising yearly. The management requires renal replacement therapy, hemodialysis, 3 sessions per week or peritoneal dialysis until the time of renal transplantation. The cost is high in low income countries and is not covered by major medical insurances. Few renal patients are able to afford dialysis and renal transplantation. Case Presentation: A 45-year-old man Butcher, living in rural Rwanda presented with renal failure and Hypertension with history of native medication intake. He remained on chronic maintenance hemodialysis since October 2017, at one to two hemodialysis sessions per month. He preserved quality of life and cognitive function. He is reporting to have more than 1000 cc of urine volume per day. Conclusion: This case demonstrates that suboptimal hemodialysis sessions can help the renal patients to survive when they preserve residual renal functions.