bluuebunny/crossref_metadata_2025 huggingface dataset:
Cash Flow Analysis оf Transport Enterprises: Problematic аnd Pragmatic Approach
Authors:   National Transport University, Boiko Nataliia
Published: June 2022

Abstract. Introduction. Timely and reliable data about cash flow should be a competitive advantage of managers of transport company in the development of strategies and tactics for managing the financial condition of enterprises in COVID-19 pandemic. In COVID-19 pandemic, it is extremely difficult to balance and synchronize cash flow. Purpose. The purpose of the article is to substantiate the methodological provisions of the analysis of cash flows of the enterprise with the distribution for rapid analysis and fundamental analysis, and testing in the practice of transport enterprises. Results. There are different approaches to determining the essence of the analysis of cash flows of the enterprise with the predominance of the process approach or auxiliary (service, infrastructure) approach in the modern professional literature on financial analysis. The author's definition of the essence of the analysis of cash flows of the enterprise is offered. Approbation of the author's methodical recommendations for the analysis of cash flows of the enterprise was carried out for ATP such as PJSC «Kyiv Production Company “Rapid”, PJSC “SATP 0904”, PJSC “Chernihiv ATP 17462”. Horizontal analysis indicates differentiation of dynamics of cash flow dynamics in 2020. PJSC «Kyiv Production Company “Rapid” and PJSC “Chernihiv ATP 17462” were characterized by an increase cash flows and the acquisition of a positive cash flow. PJSC “SATP 0904” was characterized by a decrease in cash flows and negative net cash flow. Vertical analysis indicates that PJSC “SATP 0904” concentrates incoming cash flows from the provision of freight transportation by 99%. PJSC “Chernihiv ATP 17462” receives only about half of the incoming cash flows from the provision of freight transportation and the alternative was the receipt of advances from customers. PJSC «Kyiv Production Company “Rapid” during the formation of incoming cash flows combined cash inflows from various activities with the predominance of revenues from the provision of freight, revenues from rent, refunds of taxes and fees, loans. Conclusions. The author's definition of analysis of cash flows of the enterprise follows as a complex concept: from the standpoint of the process approach and from the standpoint of the infrastructure approach is offered. It is recommended to apply different levels of complexity of cash flow analysis of transport enterprises (express analysis, fundamental analysis and situational analysis) and different techniques (horizontal analysis, vertical analysis, comparative analysis, coefficient analysis, trend analysis, factor analysis, harmonic analysis, etc.).
Human Capital, Labour Force, And Economic Growth: Case Study of Across Regions in Indonesia
Authors:   Sriwijaya University, Budiman Muhammad Akbar
Published: June 2022

Abstract. Introduction. Human development in education, health, and decent living increases, the accumulated human capital increases. The increase in production factors in the form of human development as a whole will increase output. In aggregate, an increase in the accumulation of human capital will impact the use of production factors as a source that replaces accumulated physical capital with human capital. Based on endogenous growth theory, human capital accumulation will create knowledge that will produce higher knowledge output. This research focuses on analyzing economic growth in Indonesia regarding endogenous factors, including the Government Expenditure Ratio for Education and Health, Human Development Index, and Labor Force Participation Rate by all provinces in Indonesia. The data used in this study are secondary for the period 2011-2020 and cross-sectional from 34 provinces in Indonesia. The analysis technique uses quantitative with Panel Data regression analysis tool. Purpose. This study analyzes the effect of the Government Expenditure Ratio on Education and Health, Human Development Index, and Labor Force Participation Rate on Economic Growth in Indonesia. Results. Education and Health Expenditure Ratio, HDI, and TPAK have a positive effect on Economic Growth. This condition means that every increase in Education and Health Expenditures, the human development index, and the Labor Force Participation Rate (TPAK) will increase economic growth. Overall economic growth is mostly determined by the Labor Force Participation Rate (TPAK). Conclusions. . Increasing the Proportion of Education and Health Expenditure Ratio, improving the quality of HDI, and increasing LFPR will impact increasing Economic Growth in Indonesia. Thus, to further increase spending on education and health, the availability of employment opportunities will result in the accumulation of human capital, which will increase economic growth in the long term.
Marketing Management in the System of Strategic Management of Trade Enterprises
Authors:   V.N. Karazin Kharkiv National University, Kuzmynchuk N.
Published: June 2022

Abstract. Introduction. The use of marketing management tools in the system of strategic management of trade enterprises allows to expand the potential of domestic trade enterprises in a changing environment and a high level of competition for consumer attention. Purpose. The purpose of the article is to implement marketing management tools in the activities of trade enterprises based on the principles of strategic management, the use of which will clarify the nature of strategic planning in today's changing environmental conditions. Results. The article proposes approaches to the implementation of marketing management tools in the activities of trade enterprises based on the principles of strategic management, the use of which allows to clarify the nature of strategic planning in today's changing environmental environment. The factors that emphasize the leading role of strategic management of modern enterprises in the field of trade and the principles that lie in the renewal of their long-term goals using available resources are highlighted. The modern tendencies which are characteristic of system of marketing management of the enterprises of trade and define efficiency of their activity are established. Emphasis is placed on the existence of marketing management attributes related to the management, marketing and economic performance of the enterprise. Conclusions. The study found that marketing management is a complex system with a large number of structured parts, interconnected and aimed at ensuring the stability of all areas of trade in modern market conditions. The directions of practical use of marketing approaches to management of activity of the enterprises of trade on an example of successfully operating representatives of branch are formed. Thus, the proposed toolkit will allow domestic trade representatives to formulate the most effective strategy for further development and further development in the current and future period.
Modification of the Assessment of Investment Attractiveness of the Enterprise
Authors:   Polissіa National University, Nedilska Larysa
Published: June 2022

Abstract. Introduction. The need to find sources of funding, to attract new investors and expand the range of economic partners necessitates a constant review of approaches to assessing the investment attractiveness of enterprises in order to increase its reliability, transparency and objectivity. Purpose. The purpose of the study is to identify the features of the assessment of investment attractiveness and improve its methodology. Results. The investment attractiveness of the enterprise has been defined as a complex and multifaceted concept that covers economic, technological, financial, environmental and social components and gives a comprehensive description of the potential object of investment, thus justifying the investor’s decision to invest funds with the prospect to return them and raise more. Methodological approaches to determining the investment attractiveness of economic entities have been compared; and a modified methodology developed by the authors has been proposed. The proposed methodology summarizes the value of a number of important economic, social and environmental indicators. The integrated index of investment attractiveness of domestic agricultural holdings Astarta-Kyiv, APK-Invest and MHP has been determined according to the following indicators: increase of capital and capital investment; the share of bank loans in the capital of an enterprise; the level of taxation and protection of investors’ interests; the ratio of receivables and payables; the ratio of the average monthly salary at an enterprise with the corresponding indicator at the regional level; increase in greenhouse gas emissions. It has been substantiated that application of a complex approach in the process of assessment of investment attractiveness of an enterprise (taking into account economic, social and environmental parameters) makes it possible to make informed investment decisions and to promote active development of a modern enterprise. Conclusions. This study suggests that the investment attractiveness of an enterprise is generated by a number of absolute and relative indicators, which are formed under the influence of all activities of the enterprise, as well as depend on its social, environmental and innovation policies.
Taxpayers’ Understanding Level, Self-Assessment System Easiness, and Information System Usefulness for the Willingness to Pay Taxpayers
Authors:   Sriwijaya University, Permata Dessy Sari
Published: June 2022

Abstract. Introduction. Taxpayers’ willingness to pay tax is known as the main factor to be considered in the effort to collect tax revenue. Thus, it is very important to identify any factors that will affect the willingness to pay in order to increase tax revenue. This study used a questionnaire to collect research data to identify whether taxpayers’ willingness to pay were affected by tax understanding, self-assessment system, and the use of tax information system. The research sample consisted of 302 corporate taxpayers at KPP Palembang Ilir Barat. The hypotheses of this study were tested using Partial Least Square. Purpose. This study aims to examine the relationship between the level of understanding of taxpayers, ease of selfassessment system, use of information systems, and willingness to pay for MSME taxpayers at KPP Pratama Palembang Ilir Barat and determine the steps that can be taken by KPP Pratama Palembang Ilir Barat to increase willingness to pay based on the relationship between the variables studied. Results. The results showed that the level of understanding of taxpayers and the use of taxation information systems had a positive and significant effect on the willingness to pay of MSME taxpayers, while the ease of self-assessment system did not affect the willingness to pay of MSME taxpayers. Conclusions. The hypotheses testing results and descriptive statistics analysis show that it is important for tax authority to maintain taxpayers’ willingness to pay by assuring taxpayers’ understanding of their tax obligations. It is also important to maintain a solid taxation information system to increase taxpayers’ willingness to pay. Based on our limitations, it is suggested for further researchers to examine taxpayers in a larger area and number, as well as conduct observations and interviews on tax payments that are actually carried out by taxpayers.
Institutional Support of Agricultural Market Development
Authors:   Odessa State Agrarian University, Petrenko Olga
Published: June 2022

Abstract.Introduction. The article considers the problem of institutional support for the development of the agricultural insurance market in Ukraine. The substantiation of the algorithm of reproduction of dynamic process of institutional development which is offered to be realized in three stages is given: 1) assistance of growth of mutual trust of operating subjects of the agroinsurance market; 2) settlement of consolidated liability of all participants in the insurance process in the agricultural sector; 3) creation of conditions for the functioning of a proper insurance environment in the agricultural insurance market. Results. Strategic directions of improving the institutional environment of the agricultural insurance market on the basis of systematic coordination of relevant formal (various laws and regulations, insurance conditions, etc.) and informal institutions (insurance culture, moral and ethical values, etc.), effective infrastructure and information support, effective transaction cost management are proposed. domestic insurance companies, synergistic interaction of direct (insurers, insurers and intermediaries) and indirect (governmental and non-governmental institutions) participants in the agricultural insurance process. The key condition for optimal interaction of agricultural insurance market participants is to increase the level of development of its institutional support, focused on the distribution or redistribution of risks and liability in the time lag. Conclusions.Thus, the process of institutional support for the development of the agricultural insurance market should be considered in terms of algorithmic settlement of insurance interests and opportunities for integration of formal, informal, functional and structural institutions, which are focused on ensuring a culture of providing and consuming agricultural insurance services. Emphasis is placed on the fact that the institutional support for the development of the agricultural insurance market is based on the formation of stable effective demand of potential policyholders for certain insurance services and their direct generation by various insurance companies to timely cover emerging agricultural insurance risks. To promote the sustainability of the agricultural insurance market is its modernization, which focuses on the systematic adoption of strategic measures to organize the reproduction of a proper favorable insurance environment in agricultural insurance.
Vertical Integration in Agro-Industry: Eco-Friendly Gambier Products
Authors:   Sriwijaya University, Hamira Hamira
Published: June 2022

Abstract. Introduction. Textile dyeing on fabrics and clothing causes environmental pollution and health problems. There is an innovation of natural coloring using gambier in the Gambo Muba fabric industry and the garment industry in Indonesia. Gambier farmers supply natural dye raw materials. Then through the supply chain of the Gambo Muba fabric industry and the garment industry, it causes vertical integration in the gambier agro-industry. This study uses primary data from 39 vertically integrated companies in the gambier agro-industry, including the gambier rubber industry, the Gambo Muba fabric industry, and the garment industry. The data was then analyzed using descriptive qualitative. Purpose. This study analyzes the relationship between vertically integrated industries, including the transaction costs between them, their impact of vertical integration on added value, and their profitability. Results. Vertically integrated industries have low transaction costs. The impact of vertical integration on the gambier agro-industry adds to the chain of economic activities that can increase added value and profits. Conclusions. The impact of vertical integration can reduce transaction costs, especially the supplier coordination cost component, distributor cost component, inter-company lobbying costs components. The benefits of vertical integration in the gambier agro-industry are increasing high added value, profit levels, decreasing environmental pollution, and agro-industry sustainability.
Meta-Analysis: Why Many patients with COVID-19 reporting Neurological Symptoms and Psychoneurotic Complaints. Clinical Case Reports in Khartoum-Sudan
Authors:   Auctores Publishing LLC, TagTaghi Sheykhi Mohammad
Published: June 2022

Sociologically speaking, drug abuse is the consequence of multiple factors. It may happen because of friends, loss of job, loss of spouse, and many other factors depending on socio-economic circumstances. In today's world, drugs have increased quantitatively and qualitatively. Industrial development has highly helped drugs to increase in any society. They have much been chemicalized which is widely injurious to health. Poor countries widely use the chemicalized drugs. Drug abuse usually takes place within younger generations. Inclusive economic growth on the other hand implies some sort of direct links between the macroeconomic determinants of economic growth. While the macro dimension refers to change and growth of GNP, sustainable economic growth requires inclusive growth. Based on a hypothesis, drug abuse decline would appear when there is an inclusive economic growth, poverty is minimized, and when the standards of living are raised. In a society with the least of corruption, a decline in drug abuse is expected.
Problems Regarding Comorbidity of Epilepsy with Depression in Children: A Literature Review
Authors: E. Aliyeva Sona
Published: June 2022

Objective: To review the literature on the comorbidity of epilepsy and depression in children. Materials and methods: The following scientific research systems were used to achieve the set goal: MEDLINE; PreMEDLINE; PubMed Central (PMC); Cochrane Library; Scirus. http://www.scirus.com/; Google Scholar; FDA (U.S. Food and Drug Administration); EMA (European Medicines Agency); Rxlist; The New England Journal of Medicine; British Medical Journal; Ovid MD; Best Evidence; UpToDate; Internet Grateful Med; Scientific American Medicine; Clinical Evidence; Harrison’s Online. Results: A search of the Internet and scientific journals revealed 21 sources directly or indirectly related to epilepsy and depression in children. Conclusion: An analysis of the literature has shown that despite the literature on the comorbidity of epilepsy and depression, this problem has not been studied in children. Keywords: children; epilepsy; depression; comorbidity
The Brain Fog by COVID 19: An Illustration
Authors: El Khoury Jane
Published: June 2022

This artwork made using charcoal and graphite pencil, represents the mental state experienced by many patients post COVID19 infection who develop this chronic encephalopathy, known also as “brain fog “that is still not well understood and subject of ongoing research.
Appropriate Use of Statins in The Elderly Population
Authors: Rocha Martinez Tania Leme da
Published: June 2022

Dyslipidemia as a risk factor in the elderly and its influence on morbidity and mortality remains a topic, at least, controversial for this population range. Statins, due to their LDL-c reducing effect, can improve other conditions that contribute to the morbidity and mortality of elderly patients. These pleitropic effects are of vital importance in the anti-atherosclerotic effect of statins. Pleitropic properties may also be involved in the non-cardiovascular benefits of statins, recently described. The similarity of pathological processes between middle-aged individuals and elderly people over 65 years of age, together with epidemiological data, confer that high cholesterol levels lead to a high risk in the elderly. Angiographic studies show that, even with advanced circulatory disease, the elderly respond to cholesterol-reducing therapy, with reduced risk. Dyslipidemia plays a key role in the progression of coronary artery disease and is an important predictor of coronary artery disease related events in elderly individuals. Statins are widely accepted as effective therapy for secondary prevention of cardiovascular disease. Although studies are limited, such benefits should also be extended to elderly patients. Statins are widely accepted as effective therapy for secondary prevention of cardiovascular disease. Although studies are limited, such benefits should also be extended to elderly patients. Taking into account the spectacular growth of the population over 65 years of age, including the increased longevity and knowing that if the current conditions of eating error, physical inactivity and inadequate treatment are modified, statin therapy undoubtedly represents a highly positive influence on the survival of this population group described.
About the Cover Image
Authors: Waling Andrea , Power Jennifer
Published: June 2022

It was difficult to determine the right cover for this special issue. The purpose of the issue was to encourage new ways of thinking about the phallus, and the aim was to find an image that did just this—ask people to wonder what the image is telling us. What does it represent? What is the story? It is perhaps ironic that the image we found most appealing is a device designed to prevent a penis from functioning. In the late nineteenth century, masturbation was believed to cause mental illness, and solo ejaculation was considered a form of sexual dysfunction, and this is one example of many, often brutal, devices created to physically prevent erections and masturbation. Sitting over modern blue jeans, however, the image is erotic and evokes BDSM or kink culture. The old and the new, repression and eroticism, are one and the same.
Potential feeding event of Priodontes maximus (Cingulata: Dasypodidae) by Desmodus rotundus (Chiroptera: Desmodontinae) in the Cerrado, Western Brazil
Authors: de Oliveira Marcione B. , de Andrade Henrique S. F. , Cordeiro Jose L. P. , de Oliveira Luiz Flamarion B.
Published: June 2022

Os morcegos hematófagos se caracterizam por uma complexa estrutura social e características anatômicas e fisiológicas particulares. São apresentadas evidências do uso potencial do tatu-canastra (Priodontes maximus) no espectro alimentar do morcego-vampiro-comum Desmodus rotundus. As observações foram realizadas no Parque Sesc Serra Azul, município de Rosário Oeste, Mato Grosso, Brasil, usando armadilhas fotográficas. Embora os morcegos hematófagos predem espécies nativas na natureza, os registros dessa atividade alimentar são raros. O uso de armadilhas fotográficas tem se tornado uma ferramenta eficiente para obter dados ecológicos sobre diversos mamíferos e permite avaliar as interações e associações entre as espécies de forma não invasiva.
Primjena preparata na bazi hitozana u poljoprivrednoj proizvodnji
Authors: Gluhić David
Published: June 2022

Hitozan je organski spoj koji se dobiva iz ljuski morskih školjkaša, te ima široku primjenu u poljoprivrednoj proizvodnji. Osnovni učinak hitozana je biofungicidni učinak na brojne biljne bolesti. Osim toga, hitozan ima dobar učinak protiv stresnih uvjeta tijekom rasta i razvoja biljaka. Primjenom hitozana povećava se kvaliteta plodova kao i vrijeme skladištenja, što je iznimno važno za sitno voće (jagoda, malina, kupina, borovnica). Kako je hitozan prirodan spoj, ima dozvolu za primjenu u ekološkoj poljoprivrednoj proizvodnji te je važan preparat za primjenu u ekološkoj poljoprivrednoj proizvodnji. Na razini EU označava se kao preparat na bazi osnovne tvari, sukladno EZ normi 1107/2009.
Suvremena tehnika za suzbijanje štetočinja u ekološkoj proizvodnji bilja
Authors: Šumanovac Luka , Jurišić Mladen , Lukač Petar , Zimmer Domagoj , Sito Stjepan
Published: June 2022

U radu je prikazana suvremena poljoprivredna tehnika u zaštiti bilja i to putem termičke zaštite, korištenjem podtlačnih i nadtlačnih sustava, primjenom mehaničkim putem četkastih kultivatora i primjenom suvremenih robota. Upotrebom navedenih načina omogućuje se suzbijanje štetočinja ekološkim putem koji je sve nužniji u svakodnevnoj biljnoj proizvodnji. U radu će biti dana pojašnjenja i principi rada pomoću kojih je moguće učinkovito i relativno brzo suzbiti štetočine. Uporabom navedenih omogućuje se potpuno ekološka biljna proizvodnja bez negativnih posljedica za okoliš i krajnjeg korisnika.
The Nature of Prospective Mathematics Teachers’ Designed Manipulatives and their Potential as Anchors for Conceptual and Pedagogical Knowledge
Authors: Akuom Denish O , Greenstein Steven
Published: June 2022

While traditionally teachers have been positioned as implementers of curricular materials designed by others, this work positions them as designers of their own curricular resources, thereby inviting opportunities for their exploration at the intersection of content, pedagogy, and design. As researchers accepting greater responsibility for preparing teachers to maintain a commitment to their pedagogical vision in practice, this work seeks to cultivate the imagination of humanistic forms of mathematics teaching and learning by supporting these explorations. Toward that end, this paper reports on research that examines connections between the pedagogical/conceptual knowledge that prospective teachers embed in the designs of original manipulatives and how those designs mediate the pedagogical moves they make in teaching situations. The promise of this work is in connections that may offer a viable means to support bolder connections between teacher preparation and practice. We share findings from the analysis of prospective teachers’ design activity that conveys (1) the diversity of design decisions, rationales, and mediating resources that it entailed, and (2) how the designed manipulative act as anchors for their conceptual/pedagogical moves. The implications of these findings for teacher preparation and professional learning are considered.
Значення кольору у збірці оповідань Євгена Гуцала «Діти Чорнобиля»
Authors: Кірєєва М. В.
Published: June 2022

У статті розглядається збірка оповідань «Діти Чорнобиля» Євгена Гуцала, яка розкриває особливості життя українських дітей після подій на Чорнобильській АЕС. Розглянуто особливості значення різних кольорів, які не лише передають красу природи рідного краю, але й підкреслюють негативні наслідки чорнобильської аварії, а також переплітаються зі звичаями та традиціями українського народу.
‘Fall to Rise’ : A Quest to Revive Performance of Sri Lanka’s Boutique Hotels in Post-Easter Attack
Authors: Weerarathna Ranitha Sachinthana , Jayasinghe Nipuni , Ellepola Tharuka , Balasuriya Nimesh , Uddeepa Eashani , Kanumale Umasha
Published: June 2022

This study aims to identify the factors influencing the business performance of boutique hotels in Sri Lanka, in particular, those factors that impact the most post-Easter Sunday attacks. Three major factors were identified based on past literature; these were operators’ experience and strategies, financial structure and marketing strategies. During May to July, 2020, data were collected via a questionnaire to respondents, who are owners of 53 boutique hotels. Snowball sampling was used as the sampling technique. Data were analyzed using SPSS stastical software and multiple regression was used to identify the factors that influence the performance of boutique hotels the most. The study findings conclude that the -operator’s previous experience and strategies- is the factor that influences business performance the most. Twelve semi-structured interviews were conducted to investigate/examine how boutique hotels have regained their business performance in the aftermath of the Easter Sunday attack. The analysis revealed that boutique hotels have adopted the local market strategy, the social media marketing strategy, discounts and promotional strategies, the employee lay off strategy and the employee training & development strategy to regain business performance post-Easter Sunday attacks.  This study is significant for boutique hotel owners to maximize their profits and for the government to implement better tourism-related policies, to revive Sri Lanka’s tourism industry.
The The Impact of Annual Report Readability on Agency Costs: Internal Control as Moderating Variable
Authors: Tarjo Tarjo
Published: June 2022

This examination looks at the impact of yearly report comprehensibility on organization costs with inward control as a directing variable. This examination was directed at assembling organizations recorded on the Indonesia Stock Exchange in the 2014-2017 period. The populace utilized in this investigation added up to 142 organizations, and after the determination of tests with purposive examining methods got, 44 assembling organizations would be utilized as tests in this examination. The insightful technique in this examination utilizes the different straight relapse test with Moderate Regression Analysis (MRA). The aftereffects of this investigation show the clarity of yearly reports influence office costs, which implies the higher the degree of yearly report coherence, the higher organization costs looked by investors, the inward control reinforces the impact of yearly report lucidness on office costs, which implies that with inner control can diminish the impact of report intelligibility yearly along these lines lessening office costs.
OSMANLI DEVLETİ YENİLEŞME ÇABALARININ ATATÜRK’ÜN EĞİTİMİNE VE TÜRK DÜNYASI CEDİT HAREKETİNE KATKISI
Authors: ÖZCAN Halil
Published: June 2022

“Yeni” anlamında kullanılan cedit ve “yenilikçi” anlamına gelen “ceditçilik” kavramı, medrese eğitiminin bozulmasının tespitiyle literatürde kullanılmaya başlandı. Bozulmanın eğitimde başlayıp toplumun bütününe yayılacağı bilindiği için eğitimden başlayacak yeniliğin, devletin ve toplum hayatının tamamını düzelteceği düşünüldü. Ancak bozulmanın sebebi olduğu bilinen medreseler, her alanda olduğu gibi eğitimdeki otoritesini de kaybetmek istemedi. Yenilikçiler de mektepleri medreselerin etkisinden kurtararak yeni usul, yöntem ve araçlarla eğitim yapabilmek için çareler aramaya başladılar. Bu arayışların sonucunda eskiyen ya da kendisini yenileyemediği için işlevsiz kalan medrese eğitimine çözüm bulmak amacıyla Osmanlı Devleti’nde önce askerî alanda ve okullarda Batılı tarzda yenileşme çabaları başladı. Bu çabalar, Tanzimat Devri ile birlikte sivil okul ve kurumlarda devam etti. Bu süreçte doğan Atatürk, yeni usulde eğitim veren okullarda yetişti. Türk dünyasında ise Rusya, Avrupa ve Osmanlı Devletindeki yenileşme tecrübeleri ile çareler arandı. Osmanlı ve Rusya coğrafyasındaki Türklerin amacı Avrupa’da başlayan Rönesans, reform ve aydınlanmanın temelinde modern toplum olabilmekti.
Optimal memory-type boundary control of the Bresse system
Authors: Feng Baowei , Messaoudi Salim , Soufyane Abdelaziz , Zahri Mostafa
Published: June 2022

In this paper, we study the stability of a Bresse system with memory-type boundary conditions. For a wider class of kernel functions, we establish an optimal explicit energy decay result. Our stability result improves many earlier results in the literature. Finally, we also give four numerical tests to illustrate our theoretical results using the conservative Lax–Wendroff method scheme.
Impaired fibrinolysis in severe Covid-19 infection is detectable in early stages of the disease
Authors: Watson Oliver , Pillai Suresh , Howard Matthew , Zaldua Jun-Cezar , Whitley Janet , Burgess Brian , Lawrence Matthew , Hawkins Karl , Morris Keith , Evans Phillip Adrian
Published: June 2022

BACKGROUND: A significant degree of mortality and morbidity in Covid-19 is due to thromboembolic disease. Coagulopathy has been well described in critically unwell patients on ICU. There is less clear evidence regarding these changes at the time of presentation to the Emergency Department and the progression of disease over time. OBJECTIVE: We sought to investigate whether coagulation markers can predict severity and how they change over the disease course. METHODS: Patients presenting to a single University Teaching Hospital were recruited and followed up if PCR was positive. Alongside routine blood testing, Rotational Thromboelastometry (ROTEM) was performed. Outcome data was recorded for all patients, and ROTEM values were compared across outcome groups. RESULTS: Extem and Intem Maximum Lysis were significantly reduced in those who died or required an ICU admission, indicating a reduced ability to break down clot mass in the most critically unwell patients. CONCLUSION: Comparisons between groups demonstrated that one distinguishing feature between those who require ICU admission or die of Covid-19 compared with those who survive a hospital stay to discharge was the extent to which fibrinolysis could occur. Mortality and morbidity in Covid-19 infection appears in part driven by an inability to break down clot mass.
The United Nations and the Environment: Some Personal Reflections
Authors: Dowdeswell Elizabeth
Published: June 2022

Drawing upon personal notes and memories, this article reflects on selected moments during the journey of global environmental awareness during the past 50 years. Through its convening power the United Nations, it’s myriad programs and associated organizations, has been the foundational institution. The emergence of the concept of sustainability and the existential crisis of climate change have dramatically altered the landscape during the period. Challenging questions about the governance of global interconnectedness and an agenda of peace and security that considers social inclusion, economic prosperity and environmental stewardship holistically remain a work in progress at Stockholm+50 and beyond.
On the deflection of composite reinforced steel truss-concrete beam under static and dynamic load
Authors: Zeng Xingqi , Zou Yang , Zhou Zhixiang , Yu Yanjiang , Yu Kun , Peng Hongbo , Zhang Liwen
Published: June 2022

In this study, a test beam model of negative moment region was designed to study its deflection characteristics under over-limit static load and variable amplitude cyclic load scenarios. (1) According to the deflection test results of the test beam under over-limit static load, the load-deflection curve under static load before and after 10000 times of over-limit fatigue load tended to sharply increase in the first place and then slow down afterwards. At the ultimate load, the maximum deflection value of the two was 8.625 mm and 8.76 mm, respectively. The maximum deflection value after 10000 times of over-limit fatigue load increased by 1.57% compared with that before. (2) The deflection test results of the test beam under variable amplitude cyclic load showed that both the total deflection and the residual deflection percentage increased firstly and decreased with the increasing fatigue load times. The total deflection ranged from 4.07–4.3 mm, and the residual deflection percentage was 0.1–1.65%; The residual deflection percentage reached a maximum of 1.65% when the fatigue load times reached 2 million. (3) The deflection test results of the test beam under over-limit variable amplitude fatigue load showed that the maximum residual deflection reached 0.08 mm (maximum residual deflection percentage 1.75%), 0.11 mm (maximum residual deflection percentage 2.30%), 0.16 mm (maximum residual deflection percentage 2.65%) after 1.5, 2 and 3 times over-limit variable amplitude fatigue load was imposed respectively. The maximum deflection did not fluctuate obviously, indicating that the test beam was had sound working performance. (4) In this study, the shear stiffness and fatigue load times were fully considered, the mean value of the ratio of the deformation value to the measured value of the test beam was 0.89, and the standard deviation was 4.86%. When the fatigue load times exceeded 2.8 million, the ratio of the calculated value to the measured value was less than 0.85. In conclusion, the model had its own limitations.
RETRACTED: Smoking behavior recognition based on a two-level attention fine-grained model and EfficientDet network
Authors: Li Fanshu , Yao Dengfeng , Jiang Minghu , Kang Xinchen
Published: June 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
RETRACTED: A N-gram based approach to auto-extracting topics from research articles1
Authors: Zhu Linkai , Wang Wennan , Huang Maoyi , Chen Maomao , Wang Yiyun , Cai Zhiming
Published: June 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
Covering-based generalized variable precision fuzzy rough set
Authors: Du Ye , Yao Bingxue
Published: June 2022

Zhan and Jiang defined covering-based compact and loose variable precision fuzzy rough set models. Soon after, they proposed a reflexive fuzzy β-neighborhood operator and defined a covering-based generalized variable precision fuzzy rough set. Based on them, in this paper, we use the reflexive fuzzy β-neighborhood operator to establish two covering-based generalized variable precision fuzzy rough set models, which are called covering-based generalized compact and loose variable precision fuzzy rough set models, respectively. Then, we investigate the important properties of the two rough set models and their relationship to the original models. Finally, we apply the covering-based generalized compact variable precision fuzzy rough set model to decision-making problems. A simple example is given to verify the validity of the model and compare the results with other models.
Can probiotics and prebiotics contribute to healthy ageing?
Authors: Rowland Ian
Published: June 2022

Probiotics and prebiotics have been the subject of extensive investigations into their role in human health including their effects on risk of age-related chronic diseases. There is good evidence that probiotics and, to a lesser extent prebiotics, can influence immune function in older subjects and counteract immunosenescence and increased inflammation. Probiotics have also been shown to increase the effectiveness of influenza vaccination in the elderly and reduce risk and/or duration of upper respiratory tract infections. Prebiotics and probiotics have been shown to have benefits for common gastrointestinal disorders that are common in older people, especially constipation, and there is some evidence that symptoms of metabolic syndrome can be alleviated by certain probiotics.
Gastric teratoma presenting as melena in the newborn: A case report
Authors: Bhardwaj P. , Thattaruparambil V. P. , Vellaisamy G. , Mahadevaiah S. , Hegde S.
Published: June 2022

Melena is reported in 1 of 350 to 400 new-borns. Significant upper gastrointestinal bleeding in a neonate with an antenatally diagnosed abdominal mass has not been reported before. This case highlights an unusual presentation of a gastric teratoma and proposes a probable embryological explanation for the site of occurrence.
The next generation of peer review
Authors: Gaebler-Spira Deborah , Inanoglu Didem , Williams Kayla
Published: June 2022

Peer review is an important process that produces the evidence-based medicine that guides the standards by which we provide care. We all have a role to contribute to the advancement of our field through involvement in this process. Opportunities and guidance to the next generation of reviewers is essential to continue to move our field forward and is supported by the JPRM Residents and Fellows Program.
Handling Time Constraints in Infection Clinical Pathways Using openEHR TP
Authors: Iglesias Natalia , Juarez Jose M. , Campos Manuel
Published: June 2022

Clinical Pathways (CP) provide healthcare personnel with an easy-to-understand high level model of medical steps in specific patient conditions, thereby improving overall process quality in clinical practice. The emergence of new clinical-oriented standards such as openEHR Task Planning (TP) could pose a major step towards clinical process improvement, particularly in complex domains such as infection diagnosis and treatment, where time plays a critical role. In this work, we analyze the suitability of TP to successfully represent time constraints of common process patterns in infections, modelling some of the Catheter-Related Blood Stream Infection (CR-BSI) process patterns as a case study. Our research shows that TP is useful to represent time constraints of infection CPs, although minor improvements could increase its suitability not only for infection processes but for other time-related complex clinical scenarios.
A Multi-Omics Common Data Model for Primary Immunodeficiencies
Authors: Buy Mélanie ,   ATRACTion Members, Digan William , Chen Xiaoyi , Husson Julien , Ménager Mickael , Rieux-Laucat Frédéric , Garcelon Nicolas
Published: June 2022

Primary Immunodeficiencies (PIDs) are associated with more than 400 rare monogenic diseases affecting various biological functions (e.g., development, regulation of the immune response) with a heterogeneous clinical expression (from no symptom to severe manifestations). To better understand PIDs, the ATRACTion project aims to perform a multi-omics analysis of PIDs cases versus a control group patients, including single-cell transcriptomics, epigenetics, proteomics, metabolomics, metagenomics and lipidomics. In this study, our goal is to develop a common data model integrating clinical and omics data, which can be used to obtain standardized information necessary for characterization of PIDs patients and for further systematic analysis. For that purpose, we extend the OMOP Common Data Model (CDM) and propose a multi-omics ATRACTion OMOP-CDM to integrate multi-omics data. This model, available for the community, is customizable for other types of rare diseases (https://framagit.org/imagine-plateforme-bdd/pub-rhu4-atraction).
Can Researchers Assess the Suitability of Datasets to Answer Their Research Questions, with Access to Metadata Only?
Authors: Tilston George , Williams Richard , Griffiths Emily , Al-Adely Sarah , Lawson-Tovey Saskia , Hulme Will , Short Andrea , Davies Jim , Welch James , Peek Niels
Published: June 2022

Health research increasingly requires effective ways to identify existing datasets and assess their suitability for research. We sought to test whether researchers could use an existing metadata catalogue to assess the suitability of datasets for addressing specified research questions. Five datasets were described in the National Institute for Health Research Health Informatics Collaborative metadata catalogue, and for each dataset five associated research questions were formulated, some of which were answerable with the dataset while others were not. Thirteen researchers each assessed whether the ten questions associated with two randomly selected datasets were answerable with the described datasets. After removing instances where participants misunderstood the question or lacked subject matter knowledge to make the assessment, we found that 87 out of 109 assessments (80%) were correct. Participants particularly struggled with one dataset which consisted of EHR data. The most common reason for incorrect assessments was the inability to find the relevant information in the metadata catalogue.
Protecting Privacy of Health Information, a Global Perspective
Authors: Gatchalian Nona , Kandy Mujeeb C. , Sattler Dorinda M.
Published: June 2022

The expanded use of data is part of healthcare transformation that is underway in most countries around the world. While transformation is good for the advancement of healthcare, it presents new challenges for health information professionals. It is critical that the privacy of individual health information be protected throughout the transformation process. In this abstract, we explore how transformation is taking place in various countries and at different stages as paper-based records are digitized, as electronic health records are adopted, and as health data is used in new data-sharing methods for population health, analytics, and patient engagement. It is imperative for all health information stakeholders to learn about emerging trends and new rules that will impact their work to protect the privacy of health information in an increasingly digital, mobile, and global world. These requirements, and more are explored in the whitepaper: Privacy of Health Information, an IFHIMA Global Perspective.
A Novel Personalized Random Forest Algorithm for Clinical Outcome Prediction
Authors: Johnson Adriana , Cooper Gregory F. , Visweswaran Shyam
Published: June 2022

Machine learning algorithms that derive predictive models are useful in predicting patient outcomes under uncertainty. These are often “population” algorithms which optimize a static model to predict well on average for individuals in the population; however, population models may predict poorly for individuals that differ from the average. Personalized machine learning algorithms seek to optimize predictive performance for every patient by tailoring a patient-specific model to each individual. Ensembles of decision trees often outperform single decision tree models, but ensembles of personalized models like decision paths have received little investigation. We present a novel personalized ensemble, called Lazy Random Forest (LazyRF), which consists of bagged randomized decision paths optimized for the individual for whom a prediction will be made. LazyRF outperformed single and bagged decision paths and demonstrated comparable predictive performance to a population random forest method in terms of discrimination on clinical and genomic data while also producing simpler models than the population random forest.
Clinical Comparable Corpus Describing the Same Subjects with Different Expressions
Authors: Nakamura Yuta , Hanaoka Shouhei , Nomura Yukihiro , Hayashi Naoto , Abe Osamu , Yada Shunrato , Wakamiya Shoko , Aramaki Eiji
Published: June 2022

Medical artificial intelligence (AI) systems need to learn to recognize synonyms or paraphrases describing the same anatomy, disease, treatment, etc. to better understand real-world clinical documents. Existing linguistic resources focus on variants at the word or sentence level. To handle linguistic variations on a broader scale, we proposed the Medical Text Radiology Report section Japanese version (MedTxt-RR-JA), the first clinical comparable corpus. MedTxt-RR-JA was built by recruiting nine radiologists to diagnose the same 15 lung cancer cases in Radiopaedia, an open-access radiological repository. The 135 radiology reports in MedTxt-RR-JA were shown to contain word-, sentence- and document-level variations maintaining similarity of contents. MedTxt-RR-JA is also the first publicly available Japanese radiology report corpus that would help to overcome poor data availability for Japanese medical AI systems. Moreover, our methodology can be applied widely to building clinical corpora without privacy concerns.
Associations Between Aggregate NLP-Extracted Conflicts of Interest and Adverse Events by Drug Product
Authors: Graham S. Scott , Majdik Zoltan P. , Barbour Johua B. , Rousseau Justin F.
Published: June 2022

This study evaluates associations between aggregate conflicts of interest (COI) and drug safety. We used a machine-learning system to extract and classify COI from PubMed-indexed disclosure statements. Individual conflicts were classified as Type 1 (personal fees, travel, board memberships, and non-financial support), Type 2 (grants and research support), or Type 3 (stock ownership and industry employment). COI were aggregated by type compared to adverse events by product. Type 1 COI are associated with a 1.1-1.8% increase in the number of adverse events, serious events, hospitalizations, and deaths. Type 2 COI are associated with a 1.7-2% decrease in adverse events across severity levels. Type 3 COI are associated with an approximately 1% increase in adverse events, serious events, and hospitalizations, but have no significant association with adverse events resulting in death. The findings suggest that COI policies might be adapted to account the relative risks of different types of financial relationships.