bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Papillomavirus Oral- and Sero- Positivity in Fanconi Anemia
Authors: Sauter Sharon L. , Zhang Xue , Romick-Rosendale Lindsey , Wells Susanne I. , Myers Kasiani C. , Brusadelli Marion G. , Poff Charles B. , Brown Darron R. , Panicker Gitika , Unger Elizabeth R. , Mehta Parinda A. , Bleesing Jack , Davies Stella M. , Butsch Kovacic Melinda
Published: March 2021

High-risk human papillomavirus (HPV) is prevalent and known to cause 5% of all cancers worldwide. The rare, cancer prone Fanconi anemia (FA) population is characterized by a predisposition to both head and neck squamous cell carcinomas and gynecological cancers, but the role of HPV in these cancers remains unclear. Prompted by a patient-family advocacy organization, oral HPV and HPV serological studies were simultaneously undertaken. Oral DNA samples from 201 individuals with FA, 303 unaffected family members, and 107 unrelated controls were tested for 37 HPV types. Serum samples from 115 individuals with FA and 55 unrelated controls were tested for antibodies against 9 HPV types. Oral HPV prevalence was higher for individuals with FA (20%) versus their parents (13%; p = 0.07), siblings (8%, p = 0.01), and unrelated controls (6%, p ≤ 0.001). A FA diagnosis increased HPV positivity 4.84-fold (95% CI: 1.96–11.93) in adjusted models compared to unrelated controls. Common risk factors associated with HPV in the general population did not predict oral positivity in FA, unlike unrelated controls. Seropositivity and anti-HPV titers did not significantly differ in FA versus unrelated controls regardless of HPV vaccination status. We conclude that individuals with FA are uniquely susceptible to oral HPV independent of conventional risk factors.
Germline Variation in PDCD1 Is Associated with Overall Survival in Patients with Metastatic Melanoma Treated with Anti-PD-1 Monotherapy
Authors: de With Mirjam , Hurkmans Daan P. , Oomen-de Hoop Esther , Lalouti Ayoub , Bins Sander , El Bouazzaoui Samira , van Brakel Mandy , Debets Reno , Aerts Joachim G. J. V. , van Schaik Ron H. N. , Mathijssen Ron H. J. , van der Veldt Astrid A. M.
Published: March 2021

A substantial number of melanoma patients do not benefit from therapy with anti-PD-1. Therefore, we investigated the predictive value of single nucleotide polymorphisms (SNPs) in genes related to the PD-1 axis in patients with metastatic melanoma. From 119 consecutive melanoma patients who were treated with pembrolizumab or nivolumab monotherapy, blood samples were genotyped for 11 SNPs in nine genes. Associations between SNPs and OS were tested using Cox regression analysis and internally validated by bootstrapping. For SNPs with a statistical significance, an expression quantitative trait loci (eQTL) analysis was performed. In a subset of patients, immunophenotyping was performed. Patients with a SNP in PDCD1 (804C > T; rs2227981) had a significantly poorer OS with a 3-year OS rate of 51.8%, as compared to 71% in wild type patients (hazard ratio [HR] 2.37; 95% CI: 1.11–5.04; p = 0.026). eQTL analysis showed that this SNP was associated with decreased gene expression. In addition, PDCD1 804C > T carriers had a reduced fraction of peripheral PD-1+CD4+ T cells. No other associations between SNPs and OS were found. PDCD1 804C > T is associated with poorer OS after anti-PD-1 monotherapy in patients with metastatic melanoma. This SNP may affect clinical benefit from ICIs by decreasing transcription initiation and expression of PD-1 in T cells.
Serum Exosomes and Their miRNA Load—A Potential Biomarker of Lung Cancer
Authors: Smolarz Mateusz , Widlak Piotr
Published: March 2021

Early detection of lung cancer in screening programs is a rational way to reduce mortality associated with this malignancy. Low-dose computed tomography, a diagnostic tool used in lung cancer screening, generates a relatively large number of false-positive results, and its complementation with molecular biomarkers would greatly improve the effectiveness of such programs. Several biomarkers of lung cancer based on different components of blood, including miRNA signatures, were proposed. However, only a few of them have been positively validated in the context of early cancer detection yet, which imposes a constant need for new biomarker candidates. An emerging source of cancer biomarkers are exosomes and other types of extracellular vesicles circulating in body fluids. Hence, different molecular components of serum/plasma-derived exosomes were tested and showed different levels in lung cancer patients and healthy individuals. Several studies focused on the miRNA component of these vesicles. Proposed signatures of exosome miRNA had promising diagnostic value, though none of them have yet been clinically validated. These signatures involved a few dozen miRNA species overall, including a few species that recurred in different signatures. It is worth noting that all these miRNA species have cancer-related functions and have been associated with lung cancer progression. Moreover, a few of them, including known oncomirs miR-17, miR-19, miR-21, and miR-221, appeared in multiple miRNA signatures of lung cancer based on both the whole serum/plasma and serum/plasma-derived exosomes.
The Implementation of DNA Methylation Profiling into a Multistep Diagnostic Process in Pediatric Neuropathology: A 2-Year Real-World Experience by the French Neuropathology Network
Authors: Pages Melanie , Uro-Coste Emmanuelle , Colin Carole , Meyronet David , Gauchotte Guillaume , Maurage Claude-Alain , Rousseau Audrey , Godfraind Catherine , Mokhtari Karima , Silva Karen , Figarella-Branger Dominique , Varlet Pascale ,   on behalf of the RENOCLIP-LOC Network
Published: March 2021

DNA methylation profiling has recently emerged as a powerful tool to help establish diagnosis in neuro-oncology. Here we present our national diagnostic strategy as the French neuropathology network (RENOCLIP-LOC) and our current approach of integrating DNA methylation profiling into our multistep diagnostic process for challenging pediatric CNS tumors. The tumors with diagnostic uncertainty were prospectively selected for DNA methylation after two rounds of review by neuropathology experts. We first integrated the classifier score into the histopathological findings. Subsequent analyses using t-SNE (t-Distributed Stochastic Neighbor Embedding) representation were performed. An additional step consisted of analyzing copy-number variation data (CNV). Finally, we combined all data to establish diagnoses and evaluated the impact of DNA methylation profiling on diagnostic and grading changes that would affect patient management. Over two years, 62 pediatric tumors were profiled. (1) Integrating the classifier score to the histopathological findings impacted the diagnosis in 33 cases (53%). (2) t-SNE analysis provided arguments for diagnosis in 26/35 cases with calibrated scores <0.84 (74.3%). (3) CNV investigations also evidenced alterations used for diagnosis and prognostication. (4) A diagnosis was finally established for 44 tumors (71%). Our results support the use of DNA methylation for challenging pediatric tumors. We demonstrated how additional methylation-based analyses complement the classifier score to support conventional histopathological diagnosis.
Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in CHEK2: Findings from the Australian Breast Cancer Family Registry
Authors: Nguyen-Dumont Tú , Dowty James G. , Steen Jason A. , Renault Anne-Laure , Hammet Fleur , Mahmoodi Maryam , Theys Derrick , Rewse Amanda , Tsimiklis Helen , Winship Ingrid M. , Giles Graham G. , Milne Roger L. , Hopper John L. , Southey Melissa C.
Published: March 2021

Case-control studies of breast cancer have consistently shown that pathogenic variants in CHEK2 are associated with about a 3-fold increased risk of breast cancer. Information about the recurrent protein-truncating variant CHEK2 c.1100delC dominates this estimate. There have been no formal estimates of age-specific cumulative risk of breast cancer for all CHEK2 pathogenic (including likely pathogenic) variants combined. We conducted a population-based case-control-family study of pathogenic CHEK2 variants (26 families, 1071 relatives) and estimated the age-specific cumulative risk of breast cancer using segregation analysis. The estimated hazard ratio for carriers of pathogenic CHEK2 variants (combined) was 4.9 (95% CI 2.5–9.5) relative to non-carriers. The HR for carriers of the CHEK2 c.1100delC variant was estimated to be 3.5 (95% CI 1.02–11.6) and the HR for carriers of all other CHEK2 variants combined was estimated to be 5.7 (95% CI 2.5–12.9). The age-specific cumulative risk of breast cancer was estimated to be 18% (95% CI 11–30%) and 33% (95% CI 21–48%) to age 60 and 80 years, respectively. These findings provide important information for the clinical management of breast cancer risk for women carrying pathogenic variants in CHEK2.
Association between Antiretroviral Therapy and Cancers among Children Living with HIV in Sub-Saharan Africa
Authors: Haq Heather , Elyanu Peter , Bulsara Shaun , Bacha Jason M. , Campbell Liane R. , El-Mallawany Nader K. , Keating Elizabeth M. , Kisitu Grace P. , Mehta Parth S. , Rees Chris A. , Slone Jeremy S. , Kekitiinwa Adeodata R. , Matshaba Mogomotsi , Mizwa Michael B. , Mwita Lumumba , Schutze Gordon E. , Wanless Sebastian R. , Scheurer Michael E. , Lubega Joseph
Published: March 2021

Approximately 91% of the world’s children living with HIV (CLWH) are in sub-Saharan Africa (SSA). Living with HIV confers a risk of developing HIV-associated cancers. To determine the incidence and risk factors for cancer among CLWH, we conducted a nested case-control study of children 0–18 years from 2004–2014 at five centers in four SSA countries. Incident cases of cancer and HIV were frequency-matched to controls with HIV and no cancer. We calculated the incidence density by cancer type, logistic regression, and relative risk to evaluate risk factors of cancer. The adjusted incidence density of all cancers, Kaposi sarcoma, and lymphoma were 47.6, 36.6, and 8.94 per 100,000 person-years, respectively. Delayed ART until after 2 years of age was associated with cancer (OR = 2.71, 95% CI 1.51, 4.89) even after adjusting for World Health Organization clinical stage at the time of enrolment for HIV care (OR = 2.85, 95% CI 1.57, 5.13). The relative risk of cancer associated with severe CD4 suppression was 6.19 (p = 0.0002), 2.33 (p = 0.0042), and 1.77 (p = 0.0305) at 1, 5, and 10 years of ART, respectively. The study demonstrates the high risk of cancers in CLWH and the potential benefit of reducing this risk by the early initiation of ART.
Pre-Leukemic States: United by Difference
Authors: Slape Christopher I.
Published: March 2021

Pre-leukemia is a catch-all term for any haematological condition which predisposes the individual towards developing leukemia [...]
Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation
Authors: Kim Jae-Hong , Rahman Md Habibur , Park Donghwi , Jo Myungjin , Kim Hyung-Jun , Suk Kyoungho
Published: March 2021

Transactive response DNA-binding protein 43 (TDP-43) is a ubiquitously expressed DNA/RNA-binding protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 has been implicated in numerous aspects of the mRNA life cycle, as well as in cell toxicity and neuroinflammation. In this study, we used the toxicity of the TDP-43 expression in Saccharomyces cerevisiae as an assay to identify TDP-43 genetic interactions. Specifically, we transformed human TDP-43 cDNAs of wild-type or disease-associated mutants (M337V and Q331K) en masse into 4653 homozygous diploid yeast deletion mutants and then used next-generation sequencing readouts of growth to identify yeast toxicity modifiers. Genetic interaction analysis provided a global view of TDP-43 pathways, some of which are known to be involved in cellular metabolic processes. Selected putative loci with the potential of genetic interactions with TDP-43 were assessed for associations with neurotoxicity and inflammatory activation of astrocytes. The pharmacological inhibition of succinate dehydrogenase flavoprotein subunit A (SDHA) and voltage-dependent anion-selective channel 3 (VDAC3) suppressed TDP-43-induced expression of proinflammatory cytokines in astrocytes, indicating the critical roles played by SDHA and VDAC3 in TDP-43 pathways during inflammatory activation of astrocytes and neuroinflammation. Thus, the findings of our TDP-43 genetic interaction screen provide a global landscape of TDP-43 pathways and may help improve our understanding of the roles of glia and neuroinflammation in ALS and FTD pathogenesis.
Quo Vadis: AlCr-Based Coatings in Industrial Applications
Authors: Vetter Joerg , Eriksson Anders O. , Reiter Andreas , Derflinger Volker , Kalss Wolfgang
Published: March 2021

AlCr-based hard nitride coatings with different chemical compositions and architectures have been successfully developed and applied over the last few decades. Coating properties are mainly influenced by deposition conditions and the Al/Cr content. The fcc structure is dominant for an Al-content up to Al0.7Cr0.3N and is preferred for most cutting applications. Different (AlCrX)N alloying concepts, including X = Si, W, B, V, have been investigated in order to enhance oxidation resistance and wear behaviour and to provide tribological properties. AlCr-based oxynitrides and even pure oxides (Al1−xCrx)2O3 with different crystalline structures have been explored. Multi- and nanolayered coatings within the AlCr materials system, as well as in combination with (TiSi)N, for example, have also been implemented industrially. The dominant deposition technology is the vacuum arc process. Recently, advanced high-power impulse magnetron sputtering (HiPIMS) processes have also been successfully applied on an industrial scale. This paper describes basic coating properties and briefly addresses the main aspects of the coating processes as well as selected industrial applications.
Discrete Versions of Jensen–Fisher, Fisher and Bayes–Fisher Information Measures of Finite Mixture Distributions
Authors: Kharazmi Omid , Balakrishnan Narayanaswamy
Published: March 2021

In this work, we first consider the discrete version of Fisher information measure and then propose Jensen–Fisher information, to develop some associated results. Next, we consider Fisher information and Bayes–Fisher information measures for mixing parameter vector of a finite mixture probability mass function and establish some results. We provide some connections between these measures with some known informational measures such as chi-square divergence, Shannon entropy, Kullback–Leibler, Jeffreys and Jensen–Shannon divergences.
Improving Blowout Performance of the Conical Swirler Combustor by Employing Two Parts of Fuel at Low Operating Condition
Authors: Yuan Yixiang , Zeng Qinghua , Yao Jun , Zhang Yongjun , Zhao Mengmeng , Zhao Lu
Published: March 2021

Aiming at the problem of the narrow combustion stability boundary, a conical swirler was designed and constructed based on the concept of fuel distribution. The blowout performance was studied at specified low operating conditions by a combination of experimental testing and numerical simulations. Research results indicate that the technique of the fuel distribution can enhance the combustion stability and widen the boundary of flameout within the range of testing conditions. The increase of the fuel distribution ratio improves the combustion stability but leads to an increase in NOx emission simultaneously. The simulation results show the increase of the fuel distribution ratio causes contact ratio increase in the area of lower reference velocity and gas temperature increase. The increased contact ratio and temperature contribute to the blowout performance enhancement, which is identical to the analysis result of the Damkohler number. The reported work in this paper has potential application value for the development of an industrial burner and combustor with high stability and low NOx emission, especially when the combustion system is required to be stable and efficient at low working conditions.
Examining the Linkages among Carbon Dioxide Emissions, Electricity Production and Economic Growth in Different Income Levels
Authors: Halkos George E. , Gkampoura Eleni-Christina
Published: March 2021

Our industrialized world highly depends on fossil fuels to cover its energy needs. Although fossil fuels have been linked with economic growth, their use has also been found to have severe impacts on the environment. The linkages among carbon dioxide emissions, energy consumption and economic growth have been extensively examined in the current literature. The present study focuses on electricity production from fossil fuels, as well as from renewable sources and examines their linkages with CO2 emissions and economic growth in 119 world countries of different income levels, by assessing Granger causality. In addition, the Environmental Kuznets Curve (EKC) hypothesis is tested, in order to evaluate whether economic growth and carbon dioxide emissions are linked with an inverse U-shaped relationship and with an N-shape relationship in higher income levels. The EKC hypothesis is confirmed for high income and upper-middle income countries, but not for lower-middle and low income levels and a bidirectional Granger causality is found between GDP per capita and CO2 per capita in all income levels.
Optimizing Docosahexaenoic Acid (DHA) Production by Schizochytrium sp. Grown on Waste Glycerol
Authors: Kujawska Natalia , Talbierz Szymon , Dębowski Marcin , Kazimierowicz Joanna , Zieliński Marcin
Published: March 2021

The aim of this study was to optimize biomass and docosahexaenoic acid (DHA) production by Schizochytrium sp. grown on waste glycerol as an organic carbon source. Parameters having a significant effect on biomass and DHA yields were screened using the fractional Plackett–Burman design and the response surface methodology (RSM). Schizochytrium sp. growth was most significantly influenced by crude glycerin concentration in the growth medium (150 g/dm3), process temperature (27 °C), oxygen in the bioreactor (49.99% v/v), and the concentration of peptone as a source of nitrogen (9.99 g/dm3). The process parameter values identified as optimal for producing high DHA concentrations in the biomass were as follows: glycerin concentration 149.99 g/dm3, temperature 26 °C, oxygen concentration 30% (v/v), and peptone concentration 2.21 g/dm3. The dry cell weight (DCW) obtained under actual laboratory conditions was 66.69 ± 0.66 g/dm3, i.e., 1.27% lower than the predicted value. The DHA concentration obtained in the actual culture was at 17.25 ± 0.33 g/dm3, which was 3.03% lower than the predicted value. The results obtained suggest that a two-step culture system should be employed, with the first phase focused on high production of Schizochytrium sp. biomass, and the second focused on increasing DHA concentration in the cells.
Comparative Analysis of Long-Distance Transportation with the Example of Sea and Rail Transport
Authors: Neumann Tomasz
Published: March 2021

The subject of the article is a comparative long-distance transport analysis based on the relationship between central and eastern China and Poland. It provides an overview of issues related to long-haul China–Poland. The technique for order of preference by similarity to ideal solution (TOPSIS) method was proposed in the multi-criteria analysis. This method was briefly discussed, and its choice was justified. Then, the criteria adopted in the analysis were presented, i.e., time, cost, maximum number of containers, and ecology index. Multi-criteria analysis was carried out for three cases: the transport of one loading unit, 82 loading units, and 200 loading units. The geopolitical and operational situation on the transport route for the analyzed modes of transport was discussed.
Efficiency Comparison of 2-Level SiC Inverter and Soft Switching-Snubber SiC Inverter for Electric Motor Drives
Authors: di Benedetto Marco , Bigarelli Luca , Lidozzi Alessandro , Solero Luca
Published: March 2021

This paper focuses on the investigation and implementation of a high-performance power conversion system to reduce the overvoltage phenomenon in variable speed electric drive applications. Particularly, the pros and cons of using Silicon Carbide power MOSFETs in the power converter when a long power cable is employed in electric motor drive systems has been addressed. The three-phase two level inverter with the addition of snubber circuits that consist of capacitors and diodes has been investigated, designed and tested in order to mitigate the overvoltage problems without sacrificing the conversion efficiency. Given that the snubber circuit added to the switches can increase losses, an additional circuit is used to recover the energy from the snubber circuit. The proposed analysis has been then validated through an experimental campaign performed on the converter prototype. The experimental results show that the proposed converter can reduce the overvoltage at the electric motor terminals with excellent conversion efficiency compared to the classical solution like the three-phase two level inverter.
Techno-Economic Analysis of On-Site Energy Storage Units to Mitigate Wind Energy Curtailment: A Case Study in Scotland
Authors: Canbulat Seda , Balci Kutlu , Canbulat Onder , Bayram I. Safak
Published: March 2021

Wind energy plays a major role in decarbonisation of the electricity sector and supports achieving net-zero greenhouse gas emissions. Over the last decade, the wind energy deployments have grown steadily, accounting for more than one fourth of the annual electricity generation in countries like the United Kingdom, Denmark, and Germany. However, as the share of wind energy increases, system operators face challenges in managing excessive wind generation due to its nondispatchable nature. Currently, the most common practice is wind energy curtailment in which wind farm operators receive constraint payments to reduce their renewable energy production. This practice not only leads to wastage of large volumes of renewable energy, but also the associated financial cost is reflected to rate payers in the form of increased electricity bills. On-site energy storage technologies come to the forefront as a technology option to minimise wind energy curtailment and to harness wind energy in a more efficient way. To that end, this paper, first, systematically evaluates different energy storage options for wind energy farms. Second, a depth analysis of curtailment and constraint payments of major wind energy farms in Scotland are presented. Third, using actual wind and market datasets, a techno-economic analysis is conducted to examine the relationship between on-site energy storage size and the amount of curtailment. The results show that, similar to recent deployments, lithium-ion technology is best suited for on-site storage. As case studies, Whitelee and Gordon bush wind farms in Scotland are chosen. The most suitable storage capacities for 20 years payback period is calculated as follows: (i) the storage size for the Gordonbush wind farm is 100 MWh and almost 19% of total curtailment can be avoided and (ii) the storage size for the Whitlee farm is 125 MWh which can reduce the curtailment by 20.2%. The outcomes of this study will shed light into analysing curtailment reduction potential of future wind farms including floating islands, seaports, and other floating systems.
The Changes in Thermal Transmittance of Window Insulating Glass Units Depending on Outdoor Temperatures in Cold Climate Countries
Authors: Banionis Karolis , Kumžienė Jurga , Burlingis Arūnas , Ramanauskas Juozas , Paukštys Valdas
Published: March 2021

Windows, which have a U-value that is governed by an insulating glass unit (IGU) U-value, must be a building’s only enclosure element, which has no design value concept. The declared U-value, which is calculated or measured with 0 °C of external ambient temperature, is used instead of the design value. For most of a building’s elements, its thermal transmittance with a decrease in the external temperature diminishes a little, i.e., improves. However, for modern window IGUs with Low-E coatings, it is the opposite: the thermal transmittance with a lowering external temperature increases. Therefore, for calculating the peak power for the heating of buildings it is necessary to pay attention to this phenomenon and, therefore, it would be wise to introduce the concept of design U-value for windows, recalculation rules, or affix their declared U-values. This is especially the case in modern times with the prevailing architectural tendencies for enlargement of transparent building elements. For IGUs with Low-E coatings and inert gas fillers, the thermal transmittance depends on the temperature difference between warm and cold environments. When the external temperature is −30 °C instead of 0 °C, the thermal transmittance of the IGU can increase by up to 35%. This study presents the thermal properties of windows’ IGUs depending on the changes in outdoor temperatures by using guarded a hot box climate chamber and presents the proposed simplified methodology for determining the thermal properties of windows’ glass units. The accuracy of the composed simplified methods, comparing the calculated thermal transmittances of IGUs with those measured in the “hot box”, were up to 1.25%.
Grid Support with Wind Turbines: The Case of the 2019 Blackout in Flensburg
Authors: Gloe Arne , Jauch Clemens , Räther Thomas
Published: March 2021

The work presented in this paper aims to show how modern wind turbines can help to control the frequency in a small grid which suffers from large power imbalances. It is shown for an exemplary situation, which occurred in Flensburg’s distribution grid in 2019: a major blackout, which occurred after almost two hours in islanding operation, affecting almost the entire distribution grid, which supplies approximately 55,000 households and businesses. For the analysis, a wind turbine model and a grid support controller developed at the Wind Energy Technology Institute are combined with real measurements from the day of the blackout to generate a fictional yet realistic case study for such an islanding situation. For this case study, it is assumed that wind turbines with grid support functionalities are connected to the medium voltage distribution grid of the city. It is shown to what extent wind turbines can help to operate the grid by providing grid frequency support in two ways: By supplying synthetic inertia only, where the wind turbines can help to limit the rate of change of frequency in the islanded grid directly after losing the connection to the central European grid. In combination with the primary frequency control capabilities of the wind turbines (WTs), the disconnection of one gen set in the local power station might have been avoided. Furthermore, wind turbines with primary frequency control capabilities could have restored the grid frequency to 50 Hz shortly after the islanding situation even if the aforementioned gen-set was lost. This would have allowed connecting a backup medium voltage line to the central European grid and thereby avoiding the blackout.
Low Voltage Induction Motor Traction Drive Self-Commissioning Technique with the Advanced Measured Signal Processing Procedure
Authors: Vučković Mladen , Popović Vladimir , Oros Djura , Vasić Veran , Marčetić Darko
Published: March 2021

In this paper, the enhanced auto-tuning technique based on the injection of two sinusoidal test signals of different frequencies applicable on the low voltage induction motor self-commissioning process is presented. The main feature of the proposed technique resides in the advanced signal processing of measured IM voltage and current signals based on the cascaded delay signal cancelation structure. This processing algorithm enables the filtering of the symmetry-related fundamental harmonic from the non-symmetrical test signal excitation typical for the self-commissioning process. Based upon the steady-state response from the proposed filtering block, the simple yet effective calculation method derives the complete parameter set of the IM equivalent circuit. The technique is validated through the variety of computer simulations and experimental tests on the digitally controlled low voltage IM traction drive.
Energy Processes, Systems and Equipment
Authors: Sówka Izabela , Pietrowicz Sławomir , Kolasiński Piotr
Published: March 2021

The scientific and technical issues related to energy harvesting and conversion are inseparably bound to the issues of environmental protection. Energy conversion systems and devices that are applied for converting the chemical energy contained in different fuels into heat, electricity, and cold in industry and housing are sources of different gases and solid particle emissions. Thus, the development of different technologies for energy conversion and environmental protection that can be jointly applied to cover growing energy needs has become a crucial challenge for scientists and engineers around the world. Progress in the precise description, modeling, and optimization of physical and chemical phenomena related to these energy conversion systems is a key research and development field for the economy. Legal and social issues that are affecting key aspects and problems related to the energy conversion and power sector are also significant and worth investigating. The aim of Energy Processes, Systems and Equipment Special Issue is to publish selected high-quality papers from the XV Scientific Conference POL-EMIS 2020: Current Trends in Air and Climate Protection—Control Monitoring, Forecasting, and Reduction of Emissions (29–31 March 2021, Wrocław) and other papers related to the field of energy conversion.
Innovation Management in Polish Real Estate Developers in the Renewable Energy Sources Context
Authors: Sitek Marcin , Tvaronavičienė Manuela
Published: March 2021

This paper analyses innovative activities, including renewable energy sources (RES) in the housing market, the motivations for their introduction, effectiveness, benefits, limitations and management—which are open and current problems of Polish and international sustainable construction. This problem is part of a research gap concerning, among others, the role of developers and entities responsible for introducing energy innovations into housing construction. The aim of the paper is to analyse innovations, with particular emphasis on RES, introduced by residential developers in Poland in the context of global trends. The work is based on the results of surveys conducted among developers of the primary housing market. The research of 130 questionnaires received from entities such as multi-storey buildings and multi-family houses in Poland, was carried out on a nationwide sample using the CATI Computer Assisted Telephone Interview method. The results of the survey research were summarized by setting research hypotheses, which were verified using the significance test based on the Laplace normal distribution. The research conducted has shown that residential developers in Poland point at, among others, competitive pressures, concern about the quality of products and services offered, increasing market share or satisfaction and increasing customer requirements. This clearly shows that the implementation of innovation is perceived through the prism of increasing competitiveness. Furthermore, developers operating in the more competitive markets—nationwide and on the market of the five largest Polish cities, usually larger companies, showed a greater willingness and even the need to introduce innovation in their activities. In the study, developers as one of the barriers of introducing innovations, apart from the lack of adequate support, mainly from public entities in the field of, inter alia, appropriate law favouring the implementation of innovations and financial support, indicate difficulties of the client’s market manifested by the lack of knowledge and identification of needs in the field of innovation, and the lack of willingness to pay a higher price in regard to the product with higher innovation level. In the paper, the authors recommend developers, among others, to implement in the management process the identification of possible to implement innovations and the customers’ needs in innovations with education in the field of possible innovations and its benefits. The article indicates the need to intensify the implementation of innovations in housing projects in order to increase competitiveness and to meet the European Union’s requirement regarding the use of renewable energy sources.
Using a Bottom-Up Approach to Scale Leaf Photosynthetic Traits of Oil Palm, Rubber, and Two Coexisting Tropical Woody Species
Authors: Ali Ashehad A. , Nugroho Branindityo , Moyano Fernando E. , Brambach Fabian , Jenkins Michael W. , Pangle Robert , Stiegler Christian , Blei Emanuel , Cahyo Andi Nur , Olchev Alexander , Irawan Bambang , Ariani Rahmi , June Tania , Tarigan Suria , Corre Marife D. , Veldkamp Edzo , Knohl Alexander
Published: March 2021

Rainforest conversion to woody croplands impacts the carbon cycle via ecophysiological processes such as photosynthesis and autotrophic respiration. Changes in the carbon cycle associated with land-use change can be estimated through Land Surface Models (LSMs). The accuracy of carbon flux estimation in carbon fluxes associated with land-use change has been attributed to uncertainties in the model parameters affecting photosynthetic activity, which is a function of both carboxylation capacity (Vcmax) and electron transport capacity (Jmax). In order to reduce such uncertainties for common tropical woody crops and trees, in this study we measured Vcmax25 (Vcmax standardized to 25 °C), Jmax25 (Jmax standardized to 25 °C) and light-saturated photosynthetic capacity (Amax) of Elaeis guineensis Jacq. (oil palm), Hevea brasiliensis (rubber tree), and two native tree species, Eusideroxylon zwageri and Alstonia scholaris, in a converted landscape in Jambi province (Sumatra, Indonesia) at smallholder plantations. We considered three plantations; a monoculture rubber, a monoculture oil palm, and an agroforestry system (jungle rubber plantation), where rubber trees coexist with some native trees. We performed measurements on leaves at the lower part of the canopy, and used a scaling method based on exponential function to scale up photosynthetic capacity related traits to the top of the canopy. At the lower part of the canopy, we found (i) high Vcmax25 values for H. brasiliensis from monoculture rubber plantation and jungle rubber plantation that was linked to a high area-based leaf nitrogen content, and (ii) low value of Amax for E. guineensis from oil palm plantation that was due to a low value of Vcmax25 and a high value of dark respiration. At the top of the canopy, Amax varied much more than Vcmax25 among different land-use types. We found that photosynthetic capacity declined fastest from the top to the lower part of the canopy in oil palm plantations. We demonstrate that photosynthetic capacity related traits measured at the lower part of the canopy can be successfully scaled up to the top of the canopy. We thus provide helpful new data that can be used to constrain LSMs that simulate land-use change related to rubber and oil palm expansion.
Growth Inhibitory Effect of Garlic Powder and Cinnamon Extract on White Colony-Forming Yeast in Kimchi
Authors: Kim Mi-Ju , Kang Seong-Eun , Jeong Chang Hee , Min Sung-Gi , Hong Sung Wook , Roh Seong Woon , Jhon Deok-Young , Kim Tae-Woon
Published: March 2021

White colony-forming yeast (WCFY), also referred to as film forming yeast or spoilage yeast, that appear on the surface of kimchi can deteriorate the sensory properties of kimchi, such as odor and texture. Thus, the aim of this study was to develop a method to inhibit the formation of the white colony in kimchi. First, alterations in kimchi manufacturing and storage conditions, including temperatures, pH, salinity, and anaerobic condition, were investigated to determine if they could inhibit the growth of WCFY (i.e., Kazachstania servazzii, Candida sake, Debaryomyces hansenii, Pichia kudriavzevii, and Hanseniaspora uvarum). Thereafter, the anti yeast activity of freeze-dried garlic powder (FGP) and cinnamon ethanol extract (CEE) was evaluated against WCFY using the agar-well diffusion assay. Following the direct application of FGP and CEE to the surface of the kimchi, the inhibitory effects on white colony were determined. The results showed that WCFY can grow under various manufacturing and storage conditions of kimchi. Regarding the growth inhibitory effect on WCFY, FGP exhibited anti yeast activity against four WCFYs. It did not show anti yeast activity against K. servazzii. However, CEE showed anti yeast activity against K. servazzii. In particular, the mixture of 10% FGP and 1.75% CEE, which was manufactured considering the influence of sensory properties in kimchi, exhibited anti yeast activity against all WCFY. Furthermore, the application of the FGP and CEE mixture supplemented with 0.02% xanthan gum to kimchi to enhance adhesion to the kimchi surface, led to a delay in the formation of a white colony on the surface of the kimchi by an average of 17 d at 10 °C compared to the control group. Collectively, the use of a FGP, CEE, and xanthan gum mixture could be an effective method for the inhibition of white colony formation on the surface of kimchi, extending its shelf life.
A Multi-Elements Isotope Approach to Assess the Geographic Provenance of Manila Clams (Ruditapes philippinarum) via Recombining Appropriate Elements
Authors: Won Eun-Ji , Kim Seung Hee , Go Young-Shin , Kumar K. Suresh , Kim Min-Seob , Yoon Suk-Hee , Bayon Germain , Kim Jung-Hyun , Shin Kyung-Hoon
Published: March 2021

The increasing global consumption of seafood has led to increased trade among nations, accompanied by mislabeling and fraudulent practices that have rendered authentication crucial. The multi-isotope ratio analysis is considered as applicable tool for evaluating geographical authentications but requires information and experience to select target elements such as isotopes, through a distinction method based on differences in habitat and physiology due to origin. The present study examined recombination conditions of multi-elements that facilitated geographically distinct classifications of the clams to sort out appropriate elements. Briefly, linear discriminant analysis (LDA) analysis was performed according to several combinations of five stable isotopes (carbon (δ13C), nitrogen (δ15N), oxygen (δ18O), hydrogen (δD), and sulfur (δ34S)) and two radiogenic elements (strontium (87Sr/86Sr) and neodymium (143Nd/144Nd)), and the geographical classification results of the Manila clam Ruditapes philippinarum from Democratic People’s Republic of Korea (DPR Korea), Korea and China were compared. In conclusion, linear discriminant analysis (LDA) with at least four elements (C, N, O, and S) including S revealed a remarkable cluster distribution of the clams. These findings expanded the application of systematic multi-elements analyses, including stable and radiogenic isotopes, to trace the origins of R. philippinarum collected from the Korea, China, and DPR Korea.
Forensic Behavioral Science of Serial and Mass Murder with an Addition of Leisure Research: A Descriptive Synthesis
Authors: Williams D J
Published: March 2021

Prevalence rates of multiple homicide are statistically rare and vary across nations, yet such cases create substantial suffering for victims and can generate widespread fear among the general population. Despite extreme rarity, it remains important for forensic experts and professionals to be prepared when extremely violent events occur. This review summarizes contemporary behavioral science of serial and mass murder, then highlights the application of recent leisure research to add new motivational and behavioral insights. Research on the application of leisure science to homicide research is in its infancy, yet in conjunction with other related behavioral science disciplines, appears to hold promise in understanding, and perhaps helping to prevent, future violence.
Experiences of Pathology Course among Hospital Management Graduates
Authors: Park Jung Hee , Han Woo Sok , Kim Jinkyung , Lee Hyunjung
Published: March 2021

The purpose of this study was to explore hospital management graduates’ experience in pathology courses. Data were gathered through four focus group interviews by 16 hospital management graduates who attended pathology courses. Data were collected from June to August, 2020. Conventional content analysis was used for data analysis. Six categories were extracted that described hospital management graduates’ experience in pathology courses, as follows: “Suggestions for the curriculum,” “Students’ preference for pathology professor,” “Demands for various teaching methods,” “Broad and difficult class content,” “Recognition of pathology courses during college years,” and “The importance of studying the pathology course realized after graduation.” The findings suggest that it is important to identify hospital management graduates’ perspectives to improve pathology curriculum in the educational process. Additionally, it is necessary to continuously connect educational and practical environments for the effective management of pathology courses.
Senior Managers’ Experience with Health, Happiness, and Motivation in Hospitals and the Perceived Impact on Health Systems: The Case of Meru County, Kenya
Authors: Muthuri Rose Nabi Deborah Karimi , Senkubuge Flavia , Hongoro Charles
Published: March 2021

Hospitals play a significant role in health systems. Studies among the health workforce have revealed their experiences with mental health challenges. In comparison, there is limited literature on their positive mental health. The purpose of this study was to explore senior managers’ experiences with health status, happiness, and motivation in hospitals and the perceived impact on the health system in Kenya. This qualitative study applied a phenomenological research design. Senior managers within the hospital management teams were selected using purposive sampling. Semi-structured interviews were carried out among senior managers across eleven hospitals in Meru County, Kenya. Among the eleven participants 63.6% were female and 36.4%, were male and the mean age was 44.5 years. The audio-taped data were transcribed and analyzed using Colaizzi’s phenomenological approach. The five themes revealed were: (1) Happiness in the health system; (2) Health status in the health system; (3) Motivation in the health system; (4) Challenges in the health system; (5) Possible solutions to the challenges in the health system. This study revealed the positive and negative impact of the three domains, challenges, and solutions, from the senior managers’ perspective. Healthy, happy, and motivated senior managers and healthcare workers are more responsive and perform better. Policy interventions and programs promoting happiness, health status, and motivation are necessary for strengthening the health workforce and health system.
Assessing the Impact of Land Use and Climate Change on Surface Runoff Response Using Gridded Observations and SWAT+
Authors: Kiprotich Paul , Wei Xianhu , Zhang Zongke , Ngigi Thomas , Qiu Fengting , Wang Liuhao
Published: March 2021

The Anthropocene period is characterised by a general demographic shift from rural communities to urban centres that transform the predominantly wild global landscape into mostly cultivated land and cities. In addition to climate change, there are increased uncertainties in the water balance and these feedbacks cannot be modelled accurately due to scarce or incomplete in situ data. In African catchments with limited current and historical climate data, precise modelling of potential runoff regimes is difficult, but a growing number of model applications indicate that useful simulations are feasible. In this study, we used the new generation of soil and water assessment tool (SWAT) dubbed SWAT+ to assess the viability of using high resolution gridded data as an alternative to station observations to investigate surface runoff response to continuous land use change and future climate change. Simultaneously, under two representative concentration pathways (RCP4.5 and RCP8.5), six regional climate models (RCMs) from the Coordinated Regional Climate Downscaling Experiment Program (CORDEX) and their ensemble were evaluated for model skill and systematic biases and the best performing model was selected. The gridded data predicted streamflow accurately with a Nash–Sutcliffe efficiency greater than 0.89 in both calibration and validation phases. The analysis results show that further conversion of grasslands and forests to agriculture and urban areas doubled the runoff depth between 1984 and 2016. Climate projections predict a decline in March–May rainfall and an increase in the October–December season. Mean temperatures are expected to rise by about 1.3–1.5 °C under RCP4.5 and about 2.6–3.5 °C under RCP8.5 by 2100. Compared to the 2010–2016 period, simulated surface runoff response to climate change showed a decline under RCP4.5 and an increase under RCP8.5. In contrast, the combine effects of land use change and climate change simulated a steady increase in surface runoff under both scenarios. This suggests that the land use influence on the surface runoff response is more significant than that of climate change. The study results highlight the reliability of gridded data as an alternative to instrumental measurements in limited or missing data cases. More weight should be given to improving land management practices to counter the imminent increase in the surface runoff to avoid an increase in non-point source pollution, erosion, and flooding in the urban watersheds.
Can We Reverse this Trend? Exploring Health and Risk Behaviours of Grade 12 Cohorts of Ontario Students from 2013–2019
Authors: Cole Adam G. , Laxer Rachel E. , Patte Karen A. , Leatherdale Scott T.
Published: March 2021

Adolescents engage in multiple health risk behaviours that put them at risk of future chronic disease. By the time students graduate from secondary school, they may be engaging in behaviours that set them on a particular health trajectory. It is important to monitor the co-occurrence of health risk behaviours of cohorts of grade 12 students over time to highlight important areas for intervention. The purpose of this study was to examine trends in health and risk behaviours over six waves among subsequent cohorts of grade twelve students from Ontario, Canada. A total of 44,740 grade 12 students participated in the COMPASS study across the six waves (2013/14 to 2018/19), and self-reported movement (physical activity, screen time, sleep), dietary (fruit and vegetables, breakfast), and substance use (smoking, vaping, binge drinking, and cannabis use) behaviours. Over 91.0% of students reported engaging in three or more health risk behaviours, with increases in the number of students reporting inadequate sleep, not eating breakfast on every school day, and vaping over time. Although modest, the wave 6 cohort reported slightly more risk behaviours compared with the wave 1 cohort, highlighting the importance of multidimensional health promotion strategies across multiple settings.