bluuebunny/crossref_metadata_2025 huggingface dataset:
Kondisi Ruangan Dengan Kadar Bakteriologis Udara Dalam Rawat Inap RSUP Dr. Tadjuddin Chalid Makassar
Authors: Zulfa Luthfiah , Hidayat Hidayat , Syam Nasruddin
Published: February 2022

Berdasarkan Environtmental Protection Agency (EPA), ada empat elemen yang mempengaruhi sistem pencemaran udara dalam ruang yaitu; sumber yang berasal dari dalam dan luar, sistem ventilasi (HVAC), media pembawa (udara dalam ruang) serta riwayat pekerja yang berdiam diruang tersebut apakah mempunyai penyakit yang berhubungan dengan pencemaran udara dalam ruang. Secara paparan, pencemaran udara dalam ruang jauh lebih besar dibanding pencemaran luar ruang. Kualitas fisik udara dapat mempengaruhi pertumbuhan mikroorganisme dalam ruang. Penelitian ini bertujuan untuk mengetahui kadar bakteriologis udara yang terdapat didalam rawat inap Dewasa dan rawat inap Anak RSUP Dr. Tadjuddin Chalid Makassar. Jenis penelitian ini adalah penelitian observasional dengan pendekatan deskriptif yang menyangkut ruang dengan kadar bakteriologis udara dalam rawat inap RSUP Dr. Tadjuddin Chalid Makassar. Adapun ruangan yang dipilih yaitu perawatan dewasa kamar 407, kamar 408, dan kamar 409 sedangkan pada perawatan anak kelas 3 kamar C dan kamar D.Hasil penelitian yang diperoleh menunjukkan bahwa kualitas fisik udara yaitu suhu, pencahayaan dan ventilasi masih belum memenuhi syarat sedangkan kelembaban dan angka kuman telah memenuhi syarat sesuai standar persyaratan kesehatan lingkungan rumah sakit. Disarankan bagi pengelola RSUP Dr. Tadjuddin chalid Makassar agar lebih memperhatikan kualitas fisik serta bakteriologis udara dalam ruang perawatan demi menjaga kenyamanan pasien. Kepada peneliti selanjutnya dapat menambah jumlah sampel serta mengidentifikasi jenis mikroba yang terdapat diruang perawatan RSUP Dr. Tadjuddin Chalid Makassar.
Військово-морське співробітництво України в Чорному морі та його вплив на забезпечення регіональної безпеки
Authors: Богуцький П. П.
Published: February 2022

У статті розглядаються актуальні проблеми організаційно-правового забезпечення військово-морського співробітництва України в Чорному морі в контексті захисту національних інтересів держави в умовах агресії Російської Федерації проти України. Визначено напрями військово-морського співробітництва, які поряд з реалізацією стратегічних питань розвитку Військово-Морських Сил України дають змогу забезпечити національну безпеку України на морі. Встановлено, що державна політика міжнародного військового співробітництва України в Чорному морі передбачає реалізацію двосторонніх угод з Організацією Північноатлантичного договору, з державами Альянсу, серед яких пріоритет надається регіональному співробітництву з Туреччиною та посиленню взаємодії зі стратегічними партнерами – Сполученими Штатами Америки, Великою Британією – в рамках укладених договорів, які стосуються військово-морського співробітництва в Чорному морі та мають виключно оборонний характер, маючи на меті протидію агресії РФ проти України.
Підходи до формулювання стратегії управління спільними бойовими порядками пілотованої та безпілотної авіації
Authors: Коваль В. В. , Артюшин Л. М. , Семон Б. Й. , Лобанов А. А. , Герасименко В. В.
Published: February 2022

У статті наведені підходи до формулювання стратегії управління бойовими порядками спільних авіаційних груп пілотованої та безпілотної авіації для подальшої централізації управління ними. Реалізація методологічного апарату дасть змогу обґрунтувати нові закономірності, принципи й тактичні прийоми спільного застосування пілотованої та безпілотної авіації, підходи до управління спільними бойовими порядками, які складатимуть основу для формулювання стратегії управління спільними бойовими порядками, та надати рекомендації щодо централізації управління під час застосування спільних авіаційних груп.
Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol
Authors: Lewis Celine , Buchanan James , Clarke Angus , Clement Emma , Friedrich Bettina , Hastings-Ward Jillian , Hill Melissa , Horn Ruth , Lucassen Anneke M. , Patch Chris , Pickard Alexandra , Roberts Lauren , Sanderson Saskia C. , Wynn Sarah L. , Vindrola-Padros Cecilia , Lakhanpaul Monica
Published: February 2022

Background: A new nationally commissioned NHS England Genomic Medicine Service (GMS) was recently established to deliver genomic testing with equity of access for patients affected by rare diseases and cancer. The overarching aim of this research is to evaluate the implementation of the GMS during its early years, identify barriers and enablers to successful implementation, and provide recommendations for practice. The focus will be on the use of genomic testing for paediatric rare diseases.

Methods: This will be a four-year mixed-methods research programme using clinic observations, interviews and surveys. Study 1 consists of qualitative interviews with designers/implementers of the GMS in Year 1 of the research programme, along with documentary analysis to understand the intended outcomes for the Service. These will be revisited in Year 4 to compare intended outcomes with what happened in practice, and to identify barriers and facilitators that were encountered along the way. Study 2 consists of clinic observations (pre-test counselling and results disclosure) to examine the interaction between health professionals and parents, along with follow-up interviews with both after each observation. Study 3 consists of a longitudinal survey with parents at two timepoints (time of testing and 12 months post-results) along with follow-up interviews, to examine parent-reported experiences and outcomes. Study 4 consists of qualitative interviews and a cross-sectional survey with medical specialists to identify preparedness, facilitators and challenges to mainstreaming genomic testing. The use of theory-based and pre-specified constructs will help generalise the findings and enable integration across the various sub-studies.  

Dissemination: We will disseminate our results to policymakers as findings emerge, so any suggested changes to service provision can be considered in a timely manner. A workshop with key stakeholders will be held in Year 4 to develop and agree a set of recommendations for practice.
Exploring the structural characteristics of the Adult Social Care Outcomes Toolkit (ASCOT) and ASCOT-Carer
Authors: Rand Stacey , Towers Ann-Marie , Malley Juliette , Silarova Barbora
Published: February 2022

Background: Measurement models inform the approach to assess a measure’s validity and also how a measure is understood, applied and interpreted. With preference-based measures, it is generally accepted that they are formative; however, if they are applied without preferences, they may be reflective, formative or mixed. In this study, we sought to empirically test whether the reflective, formative or mixed measurement model best describes PBMs of social care-related quality of life (ASCOT, ASCOT-Carer). We also explored the network approach, as an alternative.

Methods: ASCOT and ASCOT-Carer data were analyzed using confirmatory factor analysis and Multiple Indicators Multiple Causes models to test reflective, formative or mixed measurement models, respectively. Network analysis of partial correlations using the Gaussian graphical model was also conducted.

Results: The results indicated that the reflective measurement model is the worst fit for ASCOT and ASCOT-Carer. The formative or mixed models may apply to ASCOT. The mixed model was the best fit for ASCOT-Carer. The network analysis indicated that the most important or influential items were Occupation and Personal cleanliness and comfort (ASCOT) and Time and space and Self-care (ASCOT-Carer).

Conclusions: The ASCOT and ASCOT-Carer are best described as formative/mixed or mixed models, respectively. These findings may guide the approach to the validation of cross-culturally adapted and translated versions. Specifically, we recommend that EFA be applied to establish structural characteristics, especially if the measure will be applied as a PBM and as a measure of SCRQoL. Network analysis may also provide further useful insights into structural characteristics.
Recuperación y procesamiento de carbones de techos y pisos mezclados con estéril de la empresa Cerrejón Ltda.
Authors: Mercado Polo Luis Alberto
Published: February 2022

Los problemas que pueden existir gracias al manejo que se da en el Cerrejón han dado como resultado el deterioro de la fauna y flora de las regiones afectada; no obstante, gracias a la Política de Seguridad, Salud, Medio Ambiente y Comunidades que ofrece la compañía, se puede afirmar que dicha empresa se interesa por escuchar propuestas las cuales disminuyan el impacto ambiental que conlleva dicha actividad minera. Entre las problemáticas encontradas una de las mayores son los incendios forestales provocados por la autocombustión del carbón el cual al estar mezclados con el material estéril en algún momento tiende a subir temperaturas, ya que este carbón ha si extraído de su entorno y ha entrado en contacto con el oxígeno y con agentes externos que provocan la combustión. Hay que prestar atención al posible riesgo de su combustión espontánea debido a la presencia de carbón en los estériles y en la reacción exotérmica de oxidación de las piritas. Dados los contenidos habituales de carbón (< 5 %), si los rellenos están adecuadamente compactados, y el contenido de aire es muy bajo, puede excluirse de combustión espontánea. Un ejemplo de combustión espontánea se produjo en el terraplén entre los pp.kk. 414/850 al 415/130 de la Línea Madrid-Barcelona por Caspe. En 2006, se hizo un estudio geológico-geotécnico del terraplén que presentaba un proceso de inestabilidad debido a la combustión continua del material constituyente del núcleo, afectando a un tramo de 45 m de vía con un espesor de relleno de hasta 8 m. Al tratarse de un relleno localizado la medida correctora adoptada fue la sustitución y construcción de un nuevo terraplén.
SLOVENSKO VOJAŠKO ŠOLSTVO, ZAMUJENE PRILOŽNOSTI IN IZZIVI V PRIHODNOSTI
Authors: TOŠ DUŠAN
Published: February 2022

Dvajset let v razvoju vojaške organizacije ne pomeni veliko, če ne vidimo napredka, če smo do doseženega preveč kritični in nič ni dovolj dobro. Zelo bi bilo tudi narobe, če bi se naslonili v udobne naslanjače in bili zadovoljni z doseženim. Pogled nazaj mora biti kritičen. Pred leti sem v članku napisal: »Veliko je pomislekov o ustre- znosti vojaških šol, pa tudi o ustreznosti sistema vojaškega izobraževanja in uspo- sabljanja /.../ Napačne pa so ocene, da imamo slabo vojaško šolstvo, da je sistem, v katerem učimo in usposabljamo kader, slab. Moja ugotovitev je, da imamo točno takšne šole, kot jih zmoremo oblikovati. Za obdobje, v katerem smo delovali, je sistem tudi povsem zadoščal. Danes želimo več, boljše, drugačno.« Tudi takrat sem v prispevku podal svoj kritični pogled na narejeno in ponujal druge rešitve za doseganje po mojem mnenju bistvenega cilja in ključne stopnje v razvoju – zagoto- viti boljšo komplementarnost javnega in internega sistema vojaškega izobraževanja in usposabljanja. Twenty years in the development of a military organization does not mean much if we are completely satisfied with the progress, if we do not see any progress, if we are too critical of the progress and if we find nothing good enough. It would also be wrong to relax in a comfortable armchair and claim satisfaction with the progress made. One should be critical when looking back. Several years ago, I wrote in one of my articles: »Many question the suitability of military schools as well as the military education and training system... However, the assessments, that our military schools and the system in which we educate and train our personnel are poor, are incorrect. It is in my opinion that we have exactly those types of schools that we are able to shape. This system was completely sufficient for the period in which we operated in. Today people want something more, better, and different.« At that time, I also made a critical view of the achievements and offered other solutions to attain what I consider a vital objective and key stage in the development - to provide for a better level of complementarity of the public and internal systems of education and training.
Genetic testing in prostate cancer management: Considerations informing primary care
Authors: Giri Veda N. , Morgan Todd M. , Morris David S. , Berchuck Jacob E. , Hyatt Colette , Taplin Mary‐Ellen
Published: February 2022

Inherited genetic mutations can significantly increase the risk for prostate cancer (PC), may be associated with aggressive disease and poorer outcomes, and can have hereditary cancer implications for men and their families. Germline genetic testing (hereditary cancer genetic testing) is now strongly recommended for patients with advanced/metastatic PC, particularly given the impact on targeted therapy selection or clinical trial options, with expanded National Comprehensive Cancer Network guidelines and endorsement from multiple professional societies. Furthermore, National Comprehensive Cancer Network guidelines recommend genetic testing for men with PC across the stage and risk spectrum and for unaffected men at high risk for PC based on family history to identify hereditary cancer risk. Primary care is a critical field in which providers evaluate men at an elevated risk for PC, men living with PC, and PC survivors for whom germline testing may be indicated. Therefore, there is a critical need to engage and educate primary care providers regarding the role of genetic testing and the impact of results on PC screening, treatment, and cascade testing for family members of affected men. This review highlights key aspects of genetic testing in PC, the role of clinicians, with a focus on primary care, the importance of obtaining a comprehensive family history, current germline testing guidelines, and the impact on precision PC care. With emerging evidence and guidelines, clinical pathways are needed to facilitate integrated genetic education, testing, and counseling services in appropriately selected patients. There is also a need for providers to understand the field of genetic counseling and how best to collaborate to enhance multidisciplinary patient care.
EXPLORING ATOMS AND MOLECULES IN THE CLASSROOM: IS IT POSSIBLE?
Authors: Locatelli Solange W.
Published: February 2022

If you are a chemistry teacher, chances are you have already felt like doing an activity where students could manipulate and explore atoms or molecules in the classroom. Yes, that is right, touching, moving, uniting atoms to form molecules in a classroom, forming the most diverse substances that exist in the world, or at least observing these particles (atoms or molecules) under the microscope, as well as their constituents such as electrons and protons. But, is this possible? It is known that none of this is possible, but it would be desirable if it were, because in this way, students could better understand many phenomena of their daily lives, such as, for example, the burning of coal with the release of gases that, at a submicro level, involves the rearrangement of atoms for the occurrence of such a chemical reaction. Considering this, how to explore the particles in the classroom, which are inaccessible to the human senses, in a way that the student can understand, having an explanation of what is happening macroscopically, that is, of what he or she is observing (seeing) or even feeling, since in this case heat is released. How could we try to explain the natural world, what we experience in our daily lives?
TEACHING AND LEARNING MECHANICS EXPLORED THROUGH THE USE OF THE 5E’s EDUCATIONAL MODEL
Authors: Nkurikiyimana Jean de Dieu , Uwamahoro Jean , Ndihokubwayo Kizito
Published: February 2022

This study assesses the level of application of the 5E’s educational model by Rwandan physics teachers and how the model affects the learning of basic classical mechanics in secondary school physics classrooms. For this analysis, quantitative data were collected using the classroom observation tool framed at the 5E’s educational model. A sample of six secondary physics teachers was selected purposively from three boarding secondary schools of Nyamasheke district in the western province of Rwanda to participate in this study. Twenty-four classroom observations were conducted during teaching and learning mechanics concepts in the way of four observations for each teacher before being trained on 5E’s educational model. This was done to help the researcher to have the real picture of the prior ability of teachers to incorporate 5E’s aspects in their usual teaching practices. Similarly, a total of 24 observations were done after teachers’ training. The collected data were tabulated in Microsoft Excel, and descriptive statistics were analyzed and presented. The overall mean scores on the teachers’ ability to apply 5E’s educational model during lesson delivery on introductory mechanics were low before training and increased due to teacher training on the use of 5E’s educational model. The main findings from this study revealed that 5E’s educational model is more effective in stimulating students’ motivation and strong interaction and a better understanding of mechanics concepts through interactive activities, discrepant events, and computer simulations. Based on the findings of this study, some recommendations were suggested that would improve more physics students’ active learning. Keywords: active learning of mechanics, 5E's educational model, classroom observation, physics students, secondary school, Rwanda
IMPACT OF EXPERIENCING EVENT DESIGN WITH WEB 2.0 TOOLS ON PROSPECTIVE MATHEMATICS TEACHERS
Authors: Arabaci Aybige , Orbay Keziban
Published: February 2022

In this study, the impact of activity designing experiences with Web 2.0 tools on prospective math teachers was examined. The aim of the study was to examine the impact of activity design experiences organized with Web 2.0 tools in the mathematics teaching course on the technological pedagogical content efficacy of prospective teachers, their attitude towards teaching technologies, and rapid content development self-efficacy with Web 2.0 tools. In the study, a nested mixed method was employed. In the study conducted with 33 prospective teachers from the primary mathematics teaching department, the quantitative data was collected using the scales “Technological Pedagogical Content Knowledge”, “Self-Sufficiency for Web 2.0 Rapid Content Development” and “Attitude to Teaching Technologies”. Qualitative data was collected using an interview form. Within the scope of the distance education and “Teaching numbers” course, different Web 2.0 tools were introduced for a period of 10 weeks, and it was presented how to create activity examples that could be used in mathematics teaching. According to the quantitative results, the prospective mathematics teachers’ self-efficacy increased for rapid content development with Web 2.0 tools. In addition, it was observed that the “Attitude towards Teaching Technologies” scale had a significant effect on the sub-dimensions such as believing in the use of teaching technologies in lessons, enjoying the use of teaching technologies in lessons, and not enjoying the use of teaching technologies. In line with the opinions of prospective mathematics teachers, it was concluded that the study raised awareness about technology integration, enabled content production with Web 2.0 tools, and developed positive attitudes, new knowledge, and skills about technology.
Keywords: mathematics education, teaching numbers, distance education, teaching technology, web 2.0 tools.
Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia
Authors: Zheng Shiying Silvia , Ahmadi Zohra , Leung Halina Hoi Laam , Wong Rose , Yan Feng , Perdomo Jose Sail , Chong Beng Hock
Published: February 2022

Immune thrombocytopenia (ITP) is a bleeding disorder caused by dysregulated B- and T- cell functions, which lead to platelet destruction. A well-recognized mechanism of ITP pathogenesis involves anti-platelet and anti-megakaryocyte antibodies recognizing membrane glycoprotein (GP) complexes, mainly GPIb/IX and GPIIb/IIIa. In addition to the current view of phagocytosis of the opsonised platelets by splenic and hepatic macrophages via their Fc γ receptors, antibodyinduced platelet desialylation and apoptosis have also been reported to contribute to ITP pathogenesis. Nevertheless, the relationship between the specific thrombocytopenic mechanisms and various types of anti-platelet antibodies has not been established. In order to ascertain such association, we used sera from 61 ITP patients and assessed the capacity of anti-platelet antibodies to induce neuraminidase 1 (NEU1) surface expression, RCA-1 lectin binding and loss of mitochondrial inner membrane potential on donors’ platelets. Sera from ITP patients with detectable antibodies caused significant platelet desialylation and apoptosis. Anti-GPIIb/IIIa antibodies appeared more capable of causing NEU1 surface translocation while anti-GPIb/IX complex antibodies resulted in a higher degree of platelet apoptosis. In ITP patients with anti-GPIIb/IIIa antibodies, both desialylation and apoptosis were dependent on FcγRIIa signaling rather than platelet activation. Finally, we confirmed in a murine model of ITP that destruction of human platelets induced by anti-GPIIb/IIIa antibodies can be prevented with the NEU1 inhibitor oseltamivir. A collaborative clinical trial is warranted to investigate the utility of oseltamivir in the treatment of ITP.
Talent Scouting Children's Swimming Sport in East Langsa District
Authors: Suandi Selian  , Widiastuti  , Firmansyah Dlis  , Muhammad Syamsul Taufik
Published: February 2022

Bukit Meutuah Village, East Langsa District Langsa City is one of the villages that has the potential to contribute to gifted children because children are very fond of sports and have a high level of enthusiasm for sports activities. The location of the village is adjacent to a river that is often used by children to play and swim. However, with the existence of several existing facilities and infrastructure, the village has not been said to be fully accomplished in the field of sports both at the village and sub-district levels. This study aims to determine the swimming talent and potential of children aged 11-12 years in Bukit Meutuah Village, East Langsa District. This research was conducted by conducting a Talent Scouting Test with the Sport Search method which consisted of 10 test items which included height, weight, sitting height, arm span, throwing and catching tennis balls, throwing basketballs, jumping upright, running agility, sprinting 40 meters and multi-stage running. Sampling in this study used a total sampling technique, with quantitative descriptive research methods. Data analysis matched the test results obtained with the aptitude test scoring norm table and used percentages to describe the frequency and percentage obtained. The results showed that in the short distance swimming, all children as many as 25 people (100%) had no potential or were not talented to become candidates for short distance swimming athletes. While in long-distance swimming as many as 5 children (20%) have potential talent in long-distance swimming and as many as 20 children (80%) do not have potential or talent in long-distance swimming.
Improving 7th-grade junior high school mathematics achievement through numbered heads together
Authors: Astuti Nuryani Dwi , Pusporini Widowati
Published: February 2022

The purpose of this study was to improve the mathematics learning outcomes of class VII A students with the Numbered Heads Together (NHT) cooperative learning model on the triangle material at SMP Taman Dewasa Ibu Pawiyatan Yogyakarta. This type of research is classroom action research, while the method in this research is quantitative by collecting data through documents and tests. The subjects of this study were 21 students of class VII-A. The test instruments used were the pretest and posttest (evaluation questions in cycle I and cycle II) consisting of 20 multiple-choice questions. The data analysis technique of the mathematics learning achievement test was carried out by calculating the class average score. The results showed that there was an increase in mathematics learning achievement. This is indicated by an increase in the average percentage of student mathematics learning outcomes which increased from an average initial value of 48.33 to 67.86 in the first cycle and in the second cycle to 75.93. So it can be concluded that the Numbered Heads Together (NHT) cooperative learning model can improve the mathematics learning outcomes of class VII A students on triangle material.
Mutual Recognition Procedure for the Registration of Medicines: New Challenges or Opportunities
Authors: Foteeva A. V. , Barshadskaya O. S. , Rostova N. B.
Published: February 2022

Introduction. An important task for pharmaceutical manufacturers is to bring high quality, effective and safe medicines to the market. In the event that the country's resources are not enough, drugs that have been successfully registered in other countries come to the rescue.

Aim. To study the possibilities and advantages of the procedure of mutual recognition of registration medicinal products as a potential for the development of domestic producers.

Materials and methods. The materials of the study were available publications in peer-reviewed journals on thematic queries based on keywords of the selected topic, official websites, regulatory legal acts, regulating the procedure for registering medicinal products in the EU and the Russian Federation.

Results and discussion. New approaches to registration within the framework of the Eurasian Economic Union (using the example of the mutual recognition procedure) are considered from the perspective of new opportunities and emerging problems for domestic manufacturers of generic drugs. A comparative analysis of the mutual recognition procedure and the national procedure for registration of medicinal products revealed a number of advantages for domestic manufacturers, favoring the introduction of medicinal products into circulation on the territory of the EAEU.

Conclusion. The review of the process of harmonization of the registration practice of medicinal products in the EAEU speaks of the prospects of using the mutual recognition procedure for developing the potential of domestic manufacturers and facilitating access to effective and safe drugs.
Properties and Prospects of Application of the Whey Protein Lactoferrin in Medicine and Veterinary Medicine (Review)
Authors: Zhilyakova E. T. , Novikov O. O. , Khmyrov A. V. , Fadeeva D. A. , Gulyaeva V. E. , Malyutina A. Yu. , Avtina N. V.
Published: February 2022

Introduction. Lactoferrin is a biologically active substance, a natural glycoprotein from the group of iron-containing proteins, transferrin. This article is devoted to a review of the literature data on the properties and prospects for the use of lactoferrin in medicine and veterinary medicine.

Text. The problem of widespread use of lactoferrin is the need to use a large volume of raw materials, the difficulty of extracting it from agricultural raw materials and subsequent purification. In this view, at present, it is very promising to use transgenic animals to obtain such a valuable compound in the required volume. Discovered in 1939 in cow's milk, lactoferrin exhibits a wide spectrum of biological activity, new properties of this protein are constantly being established. The most studied are the immunomodulatory effects, anti-inflammatory, antimicrobial, antiviral, antifungal activities of lactoferrin, and the search for the possibility of using this compound for the treatment and prevention of the new coronavirus infection SARS-CoV-2, as well as for the prevention of postCOVID complications, has begun. In recent years, the antitumor activity of lactoferrin has been actively studied, as well as the prospects for its use as a biomarker for early diagnosis of neurodegenerative diseases. Lactoferrin can play a special role in the delivery of drugs to target organs, as well as in the manufacture of functional food products and various drugs for both humans and animals.

Conclusion. Thus, the performed theoretical study and the data obtained on a wide spectrum of biological activity of lactoferrin confirm the prospects and expediency of the development of formulations and technology of drugs, functional food products, veterinary drugs and animal products based on lactoferrin.
Scanning Electron Microscopy in the Analysis of Species of the Genus Persicaria Mill
Authors: Gudkova A. A. , Chistyakova A. S. , Sinetskaya D. A. , Slivkin A. I. , Bolgov A. S. , Bolgova M. A.
Published: February 2022

Introduction.Scanning electron microscopy acts as a promising method of analysis, allowing to describe in detail the identification features of closely related plant species, as well as to conduct micro-roentgenstructural analysis of the sample in the selected area with high accuracy. The method is used to study the morphology of the surface and express determination of the composition of elements in various fields (physics, materials science, medicine, however, the use of the method of scanning/raster electron microscopy for the analysis of plant raw materials in pharmacy is limited.

Aim.The purpose of the study was to study species of the genus Persicaria Mill. using scanning electron microscopy.

Materials and methods.The objects of study were the Persicaria maculosa S.F. Gray, Persicaria hydropiper (L.) Delarbre, Persicaria tomentósa (Schrank) E.P. Bicknell, Persicaria mínor (Huds.) Opiz, Persicaria amphibia (L.) Delarbre, Persicaria amphibia var. terrestris (Leyss.) Munshi & Javeid, harvested during flowering in the Voronezh region. The study of samples by scanning electron microscopy was carried out on an electron microscope JSM-6510LV (Center for Collective Use of Voronezh State University).

Results and discussion.With the help of scanning electron microscopy, morphological and anatomical signs of leaf plates of six species of the genus Persicaria were investigated and new diagnostic signs were identified. As a result of micro-X-RAY analysis, the content of some elements (potassium, calcium and magnesium) was established in the objects of study.

Conclusion.For the first time to analyze the surface morphology of the leaf plate of species of the genus Persicaria Mill. the method of scanning electron microscopy is used. The features of the stomatal apparatus, trichomes and glands on the leaves of the studied species of Persicaria are clarified. With the help of micro-roentgenstructural analysis it was found, that a greater amount of magnesium is typical for the leaves of Persicaria mínor, calcium – for the leaves of Persicaria hydropiper, and potassium – for the leaves of Persicaria maculosa.
Time Perspectives as The Predictors of Online Self-Regulated Learning
Authors: Barta Andrea , Tamás Borbála , Gálfi Bernadette , Szamosközi István
Published: February 2022

Digital education considerably requires active participation of students in the learning process, the application of self-regulated learning activities for the attainment of successful learning results. The aim of the present study is the investigation of time perspectives as the predictors of online self-regulated learning. In our study 210 Transylvanian students participated, from the Babes-Bolyai University, Faculty of Psychology and Educational Sciences. Students’ demographic characteristics were recorded, for the assessment of self-regulation the Self-regulated Online Learning Questionnaire - Revised was applied and time perspectives of students were measured by the Zimbardo Time Perspective Inventory. A correlational, cross-sectional design was used. On the basis of the results of hierarchical regression, in our first model demographic characteristics explained 5% of the variance for the application of self-regulation activities. In our second model, controlling demographic variables, time perspectives explained an additional 33% of the variance for self-regulation. Self-regulated learning strategies are predicted among demographic characteristics by students’ gender, age and online learning, while out of time perspectives only future orientation proved to be a significant predictor. Females, older students, participants attending online education and higher future orientation apply to a higher degree the self-regulated learning strategies as males, younger students and participants with lower scores at future orientation.
Canales de comunicación mediada por computador y sus efectos en la satisfacción de la comunicación
Authors: Bedoya Ever
Published: February 2022

Las redes sociales son canales que se integran a la comunicación organizacional interna. De ahí que este estudio examine el uso de la comunicación mediada por computador, la frecuencia de su uso y su posible efecto en la satisfacción de la comunicación en pymes colombianas del sector de servicios. La muestra fue de 103 personas de 4 pymes colombianas. Los resultados muestran que WhatsApp, el correo electrónico y la Intranet institucional son los canales de comunicación interna más utilizados; y que Instagram, Facebook y YouTube son los de menos uso. Asimismo, se observa que la ausencia de la comunicación mediada por computador no impacta la satisfacción de la comunicación. Las implicaciones son importantes en este momento que la emergencia sanitaria global ha obligado a recurrir al trabajo en casa.
Factores motivacionales de logro y poder y su relación con la actitud innovadora del individuo
Authors: Nahuat Román Bernardo , Ochoa Hernández Magda Lizet , Farah Simón Lisette
Published: February 2022

Existe evidencia en la literatura de que la actitud adoptada por los individuos hacia la innovación se ve influida por sus factores intrínsecos; por ello, este trabajo tiene como objetivo determinar la influencia de los factores motivacionales de logro y de poder en la actitud innovadora del individuo. El diseño metodológico adoptó un enfoque cuantitativo de corte transversal con alcance explicativo. Mediante un estudio de caso se recabaron 56 cuestionarios a trabajadores de una empresa mediana en la ciudad de Tampico, Tamaulipa; después se aplicó una regresión múltiple que evidenció la influencia positiva y significativa de los factores motivacionales de logro y de poder en la actitud innovadora del individuo. Los resultados amplían la comprensión de la relación entre los factores motivacionales y la actitud innovadora del individuo.
Pengaruh Pendapatan Asli Daerah Dan Dana Alokasi Umum Terhadap Belanja Modal (Studi Pada Kabupaten Dan Kota Di Provinsi Sulawesi Tenggara)
Authors: Nurnaluri Sitti , Husin Husin , Ibnu Sulis Ahmad
Published: February 2022

This study aims to determine the effect of Regional Original Revenues and General Allocation Funds on Capital Expenditures in Regencies / Cities in Southeast Sulawesi Province. The population in this study are regencies and cities in Southeast Sulawesi Province with the criteria that they have aged 15 years and above. The analytical method used is multiple linear regression analysis, namely the t test and F test with the help of the Statistical Package For Social Sciences (SPSS) version. 24.The results showed that the Local Revenue had a negative and not significant effect on capital expenditure. While the General Allocation Fund has a positive and significant effect on capital expenditure. Simultaneously Regional Original Revenue and General Allocation Funds affect Capital Expenditures. The coefficient of determination test shows an R Square value of 0.699, this shows that the ability of the independent variable is able to explain the dependent variable with a coefficient of determination of 69.9%, while the remaining 30.1% is explained by other variables not examined.
Programas de intervención y replicabilidad: consideraciones sobre su evaluación en psicología
Authors: Mora Romo José Fernando
Published: February 2022

En este trabajo se hace un repaso acerca de qué es la evaluación de programas de intervención, así como el procedimiento y finalidad que se ha buscado brindarle desde la psicología; y el procedimiento utilizado para llevar a cabo la replicación de estos estudios, especialmente en psicología, para así poder dar contexto a la llamada “crisis de confianza” en psicología. Esto con la finalidad de proponer que la replicabilidad de programas de intervención no podría lograrse de forma satisfactoriamente sin antes llevar a cabo un proceso de evaluación del estudio original. Para esto, se proponen tres parámetros, Factor de Bayes, Tamaño del efecto e Intervalos de Confianza; que han mostrado su utilidad en la literatura de habla inglesa, pero, sin embargo, no se ha difundido de manera extensa en aquella de habla hispana. Se propone lograr una mayor difusión de la estadística Bayesiana para solventar las problemáticas ocasionadas por la estadística frecuentista de prueba de significancia de hipótesis nula, puesto que una de las finalidades del teorema de Bayes es la acumulación y actualización continua del conocimiento obtenido de replicaciones, sin dejar de lado la evaluación de los grados de certeza de los resultados obtenidos. Así, este trabajo está dirigido para profesionistas nuevos y veteranos en el ámbito de la evaluación, que empiezan a adentrarse en la estadística como una forma de evaluar programas de investigación e intervención, por lo que se ha buscado explicar los parámetros propuestos de la forma más clara y concisa posible.
Estudio sobre el estigma percibido y el estigma experimentado según los usuarios de servicios de salud mental en la Ciudad de Buenos Aires: Su impacto en la recuperación
Authors: Geffner Norma Irene , Agrest Martín
Published: February 2022

Testimonios en primera persona de personas con padecimiento mental permiten observar que el estigma es una dinámica social que conforma uno de los más importantes obstáculos para la recuperación personal. La defensa frente a las percepciones de estigma se relaciona de manera dinámica con el proceso de recuperación y parte de una redefinición de la enfermedad como algo inesencial de la persona. Realizamos un estudio cualitativo para conocer la percepción del estigma y sus implicancias en la recuperación de veintiún usuarios que recibían tratamiento ambulatorio de salud mental en una ONG de la Ciudad Autónoma de Buenos Aires. El análisis siguió una estrategia fenomenológica. Los usuarios mencionaron con frecuencia que la ignorancia y la falta de información propia y ajena sostienen el estigma. Asimismo, destacaron  las consecuencias percibidas en la falta de abordaje de esta dinámica en los tratamientos. La familia, los amigos, el trabajo, el apoyo entre compañeros y los tratamientos que se centran en la persona y sus capacidades fueron destacados como valores fundamentales. La recuperación se percibe como un proceso relacional que incluye: cuestionar la “mirada social” (estigma) y salir del estancamiento, nuevos aprendizajes y el reconocimiento y apropiación de las transformaciones y cambios positivos a partir de los aprendizajes. El análisis de las dinámicas de estigmatización y recuperación en las palabras de los “expertos por experiencia” puede significar un avance importante para que la comprensión de estos procesos gane terreno en la formación y en las prácticas en salud mental en América Latina.
Learning and Teaching Latino Mental Health, Social Justice and Recovery to Visiting Students: A Pilot Study
Authors: Mendiola Iparraguirre Andrea Patricia , Restrepo-Toro Maria , Gomez Natalia , Costa Mark , Diaz Esperanza
Published: February 2022

Almost 18% of the U.S. population is estimated to be Hispanic (United States Census Bureau, 2019), and of that, 15% had a diagnosable mental illness in the past year (Substance Abuse and Mental Health Services Administration, 2020); still, Latinos receive half as often mental health services compared to Caucasians (Office of Mental Health, 2020). Evidence suggests that minority ethnic groups may receive more inferior care standards due to biased beliefs or attitudes held by health professionals (Shepherd et al., 2018). The number of Latino Psychiatrists is not enough to care for the on-growing Latino population in the U.S. (Alarcón, 2001; American Psychiatric Association, 2017). There is a need to train medical students and residents in cultural competencies pertained to the Latino Culture and Health Services (Alarcón, 2001). We developed a pilot study of a curriculum created by Latino bilingual and bicultural mental health providers. The course lessons include (a) Health Disparities and Implicit Bias, (b) Recovery in Mental Health, (c) Immigration and Acculturation, (d) Cultural Formulation Interview, (e) Latino Values, and (f) Mental Health Systems. All topics focused on Latino Mental Health and used the “reverse classroom” teaching technique with interactive exercises. We measured the impact on knowledge, attitudes, and comfort level related to the concept taught in the lessons of this course. Teaching Latino Mental Health has a positive impact on improving the comfort level and knowledge of students. Nevertheless, there are not enough educational opportunities and information about these topics. Therefore, replicating this curriculum and expanding the education in Latino Mental Health will improve the health services provided to this community.
Validación de una escala de empatía para niños, niñas y adolescentes colombianos
Authors: Tezón Mariana , Mesurado Maria Belen
Published: February 2022

Los estudios de empatía requieren abordar procesos afectivos, cognitivos y sociales asociados con la maduración individual, que permiten comprender la interacción social desde las disposiciones emocionales básicas. El objetivo de este estudio fue validar la escala de empatía desarrollada por Richaud, Lemos, Mesurado y Oros (2017) en una muestra de niños, niñas y adolescentes colombianos de 9 a 14 años, describiendo sus propiedades psicométricas. Para lograr este objetivo se aplicaron tres procedimientos: primero, la validez de constructo y la confiabilidad; segundo, la validez convergente, utilizando las escalas IRI (Davis, 1983) de empatía y la prosocialidad desde Caprara y Pastorelli (1993); tercero, se establecieron comparaciones de invariancia por edad y sexo en la muestra colombiana. Los resultados mostraron buenos índices de validez de constructo (Chi cuadrado/ fd = 1.72; GFI = 0.96; AGFI = 0.95, CFI = 0.94 e IFI = 0.94). La escala validada mostró buenos índices de correlación con IRI tomando dimensión de perspectiva (0,122; p <0,001) y la escala de Caprara y Pastorelli (0,204; p <0,001). El nivel de error probado fue aceptable (RMR = 0.00 y RMSEA = 0.03). Estos índices probaron que la escala de estructura de cinco factores, propuesta por Richaud, Lemos, Mesurado y Oros (2017), se confirma en la muestra colombiana. Los resultados señalaron que la escala no es invariable a través del sexo (∆CFI = 0.03) pero se confirma a través de la edad (∆CFI = 0.00). La escala validada es apropiada para medir la variable de empatía en la muestra colombiana.
Integrin α6-Targeted Molecular Imaging of Central Nervous System Leukemia in Mice
Authors: Zhang Wenbiao , Li Yongjiang , Chen Guanjun , Yang Xiaochun , Hu Junfeng , Zhang Xiaofei , Feng Guokai , Wang Hua
Published: February 2022

Central nervous system leukemia (CNS-L) is caused by leukemic cells infiltrating into the meninges or brain parenchyma and remains the main reason for disease relapse. Currently, it is hard to detect CNS-L accurately by clinically available imaging models due to the relatively low amount of tumor cells, confined blood supply, and the inferior glucose metabolism intensity. Recently, integrin α6-laminin interactions have been identified to mediate CNS-L, which suggests that integrin α6 may be a promising molecular imaging target for the detection of CNS-L. The acute lymphoblastic leukemia (ALL) cell line NALM6 stabled and transfected with luciferase was used to establish the CNS-L mouse model. CNS-L-bearing mice were monitored and confirmed by bioluminescence imaging. Three of our previously developed integrin α6-targeted peptide-based molecular imaging agents, Cy5-S5 for near-infrared fluorescence (NIRF), Gd-S5 for magnetic resonance (MR), and 18F-S5 for positron emission tomography (PET) imaging, were employed for the molecular imaging of these CNS-L-bearing mice. Bioluminescence imaging showed a local intensive signal in the heads among CNS-L-bearing mice; meanwhile, Cy5-S5/NIRF imaging produced intensive fluorescence intensity in the same head regions. Moreover, Gd-S5/MR imaging generated superior MR signal enhancement at the site of meninges, which were located between the skull bone and brain parenchyma. Comparatively, MR imaging with the clinically available MR enhancer Gd-DTPA did not produce the distinguishable MR signal in the same head regions. Additionally, 18F-S5/PET imaging also generated focal radio-concentration at the same head regions, which generated nearly 5-times tumor-to-background ratio compared to the clinically available PET radiotracer 18F-FDG. Finally, pathological examination identified layer-displayed leukemic cells in the superficial part of the brain parenchyma tissue, and immunohistochemical staining confirmed the overexpression of the integrin α6 within the lesion. These findings suggest the potential application of these integrin α6-targeted molecular imaging agents for the accurate detection of CNS-L.
Application of Artificial Neural Networks for Predicting the Stability of Rectangular Tunnels in Hoek–Brown Rock Masses
Authors: Keawsawasvong Suraparb , Seehavong Sorawit , Ngamkhanong Chayut
Published: February 2022

An artificial neural network (ANN) model for predicting the stability of rectangular tunnels in rock masses based on the Hoek–Brown (HB) failure criterion is presented in this study. Since the safety assessment of the tunnel stability is one critical issue for civil engineers during the construction, it is very important to develop a reliable and accurate stability analysis of such problems. The finite element limit analysis (FELA) with the HB failure criterion is used to develop the numerical upper and lower bound solutions of the problem of rectangular tunnels in rock masses. A novel machine learning-aided prediction of this problem is then developed based on the datasets of the numerical bound solutions obtained from the FELA. The inputs consist of six dimensionless parameters including the cover-depth ratio of tunnels, the width ratio of tunnels, the normalized uniaxial compressive strength, the geological strength index, the mi parameter, and the degree of disturbance of rock masses. The results show that the optimal ANN models provide very great accuracy in predicting the stability of the rectangular tunnels based on the HB failure criterion. The solutions will provide a prompt assessment of tunnel stability in rock masses for geotechnical engineers during the construction of rock tunnels.
CTLA-4 Facilitates DNA Damage–Induced Apoptosis by Interacting With PP2A
Authors: Yan Qiongyu , Zhang Bin , Ling Xi , Zhu Bin , Mei Shenghui , Yang Hua , Zhang Dongjie , Huo Jiping , Zhao Zhigang
Published: February 2022

Cytotoxic T-lymphocyte–associated protein 4 (CTLA-4) plays a pivotal role in regulating immune responses. It accumulates in intracellular compartments, translocates to the cell surface, and is rapidly internalized. However, the cytoplasmic function of CTLA-4 remains largely unknown. Here, we describe the role of CTLA-4 as an immunomodulator in the DNA damage response to genotoxic stress. Using isogenic models of murine T cells with either sufficient or deficient CTLA-4 expression and performing a variety of assays, including cell apoptosis, cell cycle, comet, western blotting, co-immunoprecipitation, and immunofluorescence staining analyses, we show that CTLA-4 activates ataxia–telangiectasia mutated (ATM) by binding to the ATM inhibitor protein phosphatase 2A into the cytoplasm of T cells following transient treatment with zeocin, exacerbating the DNA damage response and inducing apoptosis. These findings provide new insights into how T cells maintain their immune function under high-stress conditions, which is clinically important for patients with tumors undergoing immunotherapy combined with chemoradiotherapy.