bluuebunny/crossref_metadata_2025 huggingface dataset:
Entrepreneurial psychology: Revising the Psych 101 course
Authors: de Silva Aryanne , Ridley Dennis , Green Sarah
Published: April 2024

Extant courses in psychology typically begin with the assumption that a stable system of government exists which supports the foundation for the development of society and entrepreneurship. This approach excludes the discussion of capital or assumes its existence. The purpose of this paper is to acknowledge a new CDR index that is remarkable for explaining real gross domestic product (GDP) adjusted for purchasing power parity (G) and use it to introduce new suggestions for teaching psychology as it applies to entrepreneurship theory. It is assumed that the pertinent psychology course is available as a required or optional course for business administration students. The benefit to psychology students is to expand their knowledge about growing areas within psychology and to enable them to join the entrepreneurship community even if they are not themselves entrepreneurs. The benefit to business students is to join the entrepreneurial community as well as to become successful entrepreneurs, as well as help further develop those critical thinking skills that are typically advanced in psychology courses.
A critical analysis of the AIAG-VDA FMEA; does the newly released AIAG-VDA method offer improvements over the former AIAG method?
Authors: Kluse Christopher
Published: April 2024

After several years of collaboration, The Automotive Industry Action Group (AIAG) and The German Association of the Automotive Industry (VDA) completed a harmonized version of their respective FMEA methods. Previous to the joint initiative, each organization had their own Failure Modes and Effects Analysis (FMEA) recommended methods & guidelines. The differing methods posed confusion among those automotive suppliers that supplied both markets. As a result, the AIAG & VDA FMEA 1st edition Handbook (2019) was created to mitigate the confusion, improve the overall FMEA development process, and to improve efficiency developing accurate, robust and effective FMEA's. The AIAG-VDA 1st edition (2019) may or may not have improved the method or offered efficiency gains to the FMEA development process. Early critique of the new method offered by Harpster (2018) stated "If the AIAG-VDA DFMEA methodology (which uses structure, function, and failure analyses to determine critical DFMEA content) is implemented, it will result in an automotive DFMEA process that is both considerably less effective and much more inefficient than the current methodology described in the AIAG 4th Edition FMEA manual". This result of this research is a critical, holistic review of the recently published (June 2019) AIAGVDA FMEA Handbook along with summarized advantages and disadvantages associated with the new automotive FMEA development process. While the new FMEA AIAG-VDA process offers several advantages, and results in a more robust FMEA, the increased complexity, need for dedicated software, and the learning curve associated with the new process may represent a significant barrier to improving the FMEA development process in the automotive community.
Using tolerance interval method as an alternate approach for monitoring process performance (process capability) of surface roughness of gear tooth flanks to avoid grinding burns
Authors: Diam Akaff S. , Zhang Julie Z. , Kashef Ali E.
Published: April 2024

The process capability measures most commonly referred to as process capability indices (PCIs), Cp, Cpk, Cpm evaluate process yield, process consistency and statistical variation compared to the specification. This paper explores an alternate approach for monitoring the process performance of tooth flank surface roughness in gear tooth grinding to avoid grinding burn. The gear tooth flanks are susceptible to microstructural damage due to high thermal energy generated during the process of grind operation. The thermal damage in ground gears can cause catastrophic failure in gears' intended life. To avoid grinding burns the process parameters (feed, speed and depth of cut) are selected such that thermal damage should not occur, however, setting up such parameters could affect the process capability of surface roughness (finish) at a desired level. The surface roughness is commonly specified in design as unilateral tolerance and considered as a critical or key characteristic, therefore, most of the automotive or component manufacturing industry requires it to exhibit a process capability index (Cpk) of 1.33 or above. Achieving and maintaining process capability of surface roughness is difficult due to the nature of process, moreover, the thermal damage of the ground feature can impair the product life. In this paper, for gears that are made with ferrous materials (plain carbon steels or alloy steels), tolerance interval method is proposed for monitoring the process performance of roughness in gear tooth grinding process as compared to the conventional process capability.
Open-source embedded Linux mobile robot platform for Mechatronics Engineering and IoT Education
Authors: Hur Byul , Malawey David , Morgan Joseph A. , Song Xingyong , Langari Reza
Published: April 2024

An embedded Linux mobile robot was designed to support teaching in Multidisciplinary Engineering Technology (MXET) at Texas A&M University. This robot is the Sensing, Connected Utility Transport Taxi for Level Environments (SCUTTLE). It is a payload-ready mobile platform made from off-the-shelf parts and 3D printed designs. SCUTTLE integrates a camera, ultrasonic sensor, encoders, optional LIDAR, and various sensors. SCUTTLE has been used in lab lessons since 2019 in the Mobile Robotics undergraduate course (MXET 300). The mechanical, hardware, and software source codes are open and available on GitHub to support mechatronics education.
Profesionalitas Guru Dalam MengimplementasikanPembelajaran PAI Berbasis Kurikulum Merdeka
Authors: Eliwatis Eliwatis , Syarosy Asa , Maimori Romi , Susrizal Silvia , Demina Demina , Mudinillah Adam
Published: April 2024

Pandemi COVID-19 telah memberikan dampak yang signifikan terhadap banyak aspek kehidupan, termasuk sistem pendidikan. Kurikulum 13 menekankan pembelajaran aktif yang melibatkan interaksi langsung dan kolaborasi didalam kelas. Pengalaman belajar seperti itu sulit diwujudkan. Untuk itu, Kemendikbud meluncurkan kurikulum baru yakninya kurikurulum merdeka yang berstandar diferensiasi siswa. Konsep dari kurikulum baru ini adalah student center yang juga menuntut adanya profesionalitas guru dalam implementasinya. Penelitian ini bertujuan untuk mengetahui bagaimana implementasi dan perkembangan guru PAI secara professional dalam menerapkan kurikulum merdeka dalamperencanaan, pelaksanaan, dan evalusi di SMP kec. Limakaum, Tanah Datar. Penelitian dilakukan menggunakan pendekatan kualitatif deskriptif. Metode pengambilan data menggunakan wawancara, observasi, dan dokumentasi.Koleksi data, reduksi data, penyajian data, dan penarikan kesimpulan adalah langkahlangkah yang digunakan untukmemastikan bahwa data sesuai dengan masalah yang diteliti.  Temuan ini menunjukkan bahwa sebagian guru PAI di Kec. Limakaum sudah menggunakan standar perencanaanyakninya modul ajar yang sesuai, sebagian lagi belum begitu sesuai dengan perumusan tujuan pembelajaran dalam tahap pelaksanaaan, gaya mengajar berdiferensiasi belum secaramerata guru PAI di kec. Limakaum terapkan. Begitupun pada tahap evaluasi yang belum menerapkan segala jenis penilaian sesuai stadar kurikulum merdeka. Secara dominan, guru PAI kec. Limakaum masih menggunakan salah satu jenis evaluasi bahkan belum sama sekali menggunakan evaluasi berstandar kurikulum merdeka yang masih berpatok pada perspektif menilai cara terdahulu. Serta mengetahui apa pengaruh profesionalitas guru dalam menerapkan pembelajaran PAI berbasisi kurikulum merdeka. Dalam menggunakan Kurikulum Merdeka, guru dalam lingkungan pendidikan harus lebih dinamis dan relevan. Pendidik harus memiliki kompetensi yang memadai, yakninya profesionalitas
Peran Kinerja Karyawan Yang Dipersepsikan Oleh Pelatihan, Kompensasi, Dan Lingkungan Kerja PT Perkasa Karya Mandiri Di Kota Batam
Authors: Somi Balun Bernardus
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan, kompensasi dan lingkungan kerja terhadap kinerja karyawan PT Perkasa Karya Mandiri di Batam baik secara parsial maupun simultan. Jenis penelitian yang diterapkan dalam penelitian ini yaitu penelitian kuantitatif, populasi pada penelitian ini 127 orang. Peneliti menggunakan teknik sampling sistematis dengan jumlah responden 63 orang. Teknik pengumpulan data menggunakan kuesioner dan disebarkan melalui google form. Analisa data menggunakan SPSS versi 26 hasil penelitian menemukan bahwa variabel pelatihan mempunyai nilai thitung -0,802 < ttabel 2,001 dan nilai signifikansi 0,426 > 0,05, maka H0 diterima dan Ha ditolak, variabel kompensasi mempunyai thitung 2,622 > ttabel 2,001 dan nilai signifikansi sebesar 0,011 < 0,05, maka H0 ditolak dan Ha diterima, variabel lingkungan kerja mempunyai thitung 3,996 > ttabel 2,001 dan nilai signifikansi sebesar 0,000 < 0,05 maka, H0 ditolak dan Ha diterima. Ketiga variabel yaitu pelatihan, kompensasi dan lingkungan kerja secara bersama-sama mempunyai fhitung sebesar 32,723 ftabel 2,76 dan nilai signifikansi sebesar 0,000 < 0,05. Hal ini menunjukkan bahwa secara simultan pelatihan, kompensasi dan lingkungan kerja berpengaruh positif dan signifikan terhadap kinerja karyawan PT Perkasa Karya Mandiri di Batam. Dan koefisien determinasi (R2) menunjukkan bahwa variabel bebas berkontribusi sebesar 60,6% sedangkan sisanya 39,4% dipengaruhi oleh faktor lain yang tidak diteliti dalam penelitian ini.

Kata Kunci: Pelatihan, Kompensasi, Lingkungan Kerja, Kinerja
Pengaruh Kompensasi, Motivasi, Dan Disiplin Kerja Terhadap Kepuasan Kerja Karyawan Pada PT Karya Kimtek Mandiri Kota Batam
Authors: Atmojo Agus Sekti Susila
Published: April 2024

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Pengaruh Brand Image, Kualitas Layanan, dan Kepercayaan Terhadap Loyalitas Nasabah di PT KCP Bank Mandiri Tbk. Sentosa Perdana Kota batam
Authors: Dabur Feliks
Published: April 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh Brand Image, Kualitas Layanan, Kepercayaan Berpengaruh terhadap Loyalitas Nasabah di PT KCP Bank Mandiri Tbk. Sentosa Perdana Kota Batam. Penelitian ini dilakukan dengan menggunakan metode penelitian kuantitatif dengan jumlah populasi 14.444 dan sampel yang digunakan sebanyak 100 responden dengan menggunakan  pengambil rumus Slovin dan pengumpulan data menggunakan kuesioner. Hasil penelitian ini menemukan bahwa model regresi linear berganda yaitu Y= -0,960 + 0,001X1 + 0,463X2 + 0,478X3 + e. thitung sebesar 0,004 < ttabel 1,661 dengan signifikansi 0,545 > 0,05, maka brand image tidak berpengaruh dan signifikan terhadap loyalitas nasabah. thitung sebesar 3,928 > ttabel 1,661 dengan tingkat signifikansi 0,000 < 0,05, maka kualitas layanan terdapat pengaruh positif dan signifikan terhadap loyalitas nasabah, maka kepercayaan adalah sebesar 3,974 dengan tingakat signifikansi 0,000 <  ( 0,05) dan thitung 3,974 > 1,661 maka Ha diterima H0 ditolak. Artinya dapat disimpulkan bahwa secara persial kepercayaan berpengaruh positif dan signifikan terhadap loyalitas nasabah. Dari uji F menunjukkan bahwa nilai fhitung untuk brand image, kualitas layanan, kepercayaan adalah sebesar 168,234 > ftabel 2,71 dengan tingkat signifikansi sebesar 0,000 < 0,05. Hal ini menunjukkan bahwa variabel brand image, kualitas layanan, dan kepercayaan secara simultan berpengaruh positif dan signifikan terhadap loyalitas nasabah di PT KCP Bank Mandiri Tbk. Sentosa Perdana Kota Batam.
UPAYA PENCEGAHAN RISIKO KECELAKAAN KERJA DALAM KEGIATAN STEVEDORING SUPPLY VESSEL OSAM MANILA PADA PT EASTERN LOGISTICS LAMONGAN SHOREBASE
Authors: Sihombing Hotmanahan , Fauzan Haidar Nur
Published: April 2024

Upaya Pencegahan Risiko Kecelakaan Kerja Kegiatan Stevedoring Supply Vessel Osam Manila Pada PT Eastern Logistics Lamongan Shorebase masih terdapat kendala. Permasalahan dalam penelitian ini adalah : kurangnya kepedulian Tenaga Kerja Bongkar Muat (TKBM) terhadap Keselamatan dan Kesehatan Kerja, tidak ada pengawasan dari Departement Health Safety and Environment (HSE) saat kegiatan stevedoring berlangsung. Tujuan penelitian ini adalah : Untuk mengetahui upaya pencegahan risiko kecelakaan kerja terhadap Tenaga Kerja Bongkar Muat (TKBM) pada saat kegiatan stevedoring di jetty pada PT Eastern Logistics Lamongan Shorebase.Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif dengan desain kualitatif. Penelitian ini dilaksanakan di PT Eastern Logistics Lamongan Shorebase dari bulan Februari 2018 sampai dengan bulan Juli 2018. Teknik pengumpulan data menggunakan wawancara (interview), observasi dan dokumentasi. Data yang telah terkumpul kemudian dilakukan reduksi data, penyajian data, dan penarikan kesimpulan. Sedangkan informan yang dijadikan penelitian adalah Supervisor Jetty, dan Tallyman.Hasil penelitian ini adalah : 1) upaya pencegahan penyebab timbulnya risiko kecelakaan kerja terhadap Tenaga Kerja Bongkar Muat (TKBM) saat kegiatan stevedoring di jetty pada PT Eastern Logistics Lamongan Shorebase adalah : terpasangnya cctv dan kartu Hazard Observation Card (HOC) sebagai alat untuk mengetahui jika terjadinya keadaan/ kondisi tidak aman, pada saat proses stevedoring berlangsung wajib dibawah pengawasan Departement Health Safety and Environment (HSE), mensosialisasikan peraturan Keselamatan dan Kesehatan Kerja yang berlaku dengan memberikan sanksi tegas kepada TKBM yang masih tetap melanggar, mengadakan diklat Basic Safety Trainning untuk TKBM dan pekerja lainnya, sebelum melaksanakan kegiatan stevedoring wajib melaksanakan safety briefing/ internal meeting, menambah rambu-rambu Keselamatan dan Kesehatan Kerja di area jetty yang disesuaikan dengan risiko yang ada pada saat kegiatan stevedoring tersebut. 2) penyebab timbulnya risiko kecelakaan kerja kegiatan stevedoring perlu adanya pengawasan, yaitu : mencegah terjadinya risiko kecelakaan kerja, memperbaiki dan memberikan arahan ketika terdapat kondisi yang tidak aman, untuk meningkatkan Keselamatan dan Kesehatan Kerja, sehingga tercipta rasa aman dan nyaman.
PENGARUH ASMETRI INFORMASI, LEVERAGE DAN PROFITABILITAS TERHADAP MANAJEMEN LABA RIIL (Studi Empiris Pada Perusahaan Manufaktur Yang Terdaftar Di Indeks JII Periode 2004-2013)
Authors: Puspitasari Noviana
Published: April 2024

Penelitian ini secara umum bertujuan untuk menganalisis pengaruh asimetri informasi, leverage dan profitabilitas terhadap manajemen laba riil. Tujuan penelitian ini adalah untuk mendapatkan bukti empiris bahwa asimetri informasi, leverage dan profitabilitas terhadap manajemen laba riil pada perusahaan manufaktur go public yang tergabung dalam Indeks LQ-45 dan JII.Sampel yang digunakan dalam penelitian ini adalah 181 perusahaan untuk indeks LQ-45 dan 163 perusahaan untuk JII. Teknik pengamilan sampel dengan metode Purposive Sampling.Metode analisis data yang digunakan adalah regresi liniear berganda sedangkan uji statistik dengan menggunakan Uji R2 , Uji F dan Uji t(pengujian hipotesis).Hasil dari penelitian ini menunjukkan untuk indeks LQ-45 asimetri informasi berpengaruh terhadap manajemen laba riil, leverage dan profitabilitas tidak berpengaruh terhadap manajemen laba riil sedangkan untuk indeks JII asimetri informasi tidak berpengaruh terhadap manajemen laba, leverage dan profitabilitas berpengaruh terhadap manajemen laba.
PENGURUSAN DOKUMEN IMPOR SEMENTARA MELALUI JALUR LAUT PADA PT JATRINDO ANTARANSENTRA
Authors: Sugiyanto Arif Nofa , Argo Prapdita Budi
Published: April 2024

Pengurusan dokumen impor sementara sangat penting untuk barang-barang yang akan di ekspor kembali ke negara asal (re-ekspor). Beberapa masalah yang ada antara lain: barang impor sementara tidak memiliki paspor, serta penolakan atas permohonan ijin impor sementara oleh Bea & Cukai. Tujuan penelitian ini adalah: 1) untuk mengetahui proses impor sementara, 2) mengetahui proses pengurusan dokumen dan perijinan impor sementara, dan 3) untuk mengetahui adakah hambatan dalam pengurusan dokumen impor sementara.Penelitian ini adalah termasuk jenis penelitian kualitatif deskriptif yang akan mendeskripsikan bagaimana proses impor sementara dan proses pengurusan dokumen impor sementara. Penelitian dilaksanakan pada Februari sampai dengan Agustus 2019 di PT Jatrindo Antaransentra Jakarta. Teknik pengumpulan data yang digunakan adalah observasi, wawancara pada narasumber kantor PT Jatrindo Antaransentra Jakarta. Teknik analisa data yang digunakan yaitu reduksi data, penyajian data, penarikan kesimpulan.Hasil penelitian menunjukkan bahwa pelaksanaan impor sementara di PT Jatrindo Antaransentra diuraikan dalam tiga tahap yaitu (1) pelengkapan dokumen sebelum dilaksanakan impor sementara, (2) pengajuan ke Bea & Cukai serta pelaksanaan impor sementara, dan (3) pengembalian barang ke negara asal. Proses pengurusan dokumen impor sementara dilaksanakan dengan: (1) persiapan petugas bagian customs, (2) persiapan dokumen ke Bea & Bukai, (3) pengajuan surat permohonan ijin impor sementara, (4) pembuatan dokumen pemberitahuan impor barang, (5) penerbitan surat penjaluran, (6) pemeriksaan barang di pelabuhan, (7) pengambilan delivery order, (8) penerbitan surat penyerahan peti kemas, dan (9) proses unstuffing. Upaya yang dilakukan untuk mengatasi hambatan yang ada yaitu: (1) penolakan dari Bea & Cukai untuk permohonan ijin dengan jaminan tertulis, maka pihak importir melakukan pengajuan kembali dalam bentuk permohonan jaminan customs bond sehingga mendapatkan ijin dari Bea & Cukai, (2) masalah keterlambatan original dokumen, pihak importir bagian messenger selalu menghubungi dan memastikan untuk permintaan original dokumen supaya segera dikirim agar dapat segera diselesaikan pengurusan impor supaya tidak timbul demurrage.
ANALISIS KEPEDULIAN MASYARAKAT TERHADAP ASURANSI SEBAGAI MITIGASI RESIKO DALAM PERLINDUNGAN ASET
Authors: Sukoco Johan Bhimo
Published: April 2024

Asuransi merupakan produk yang ditujukan dalam memberikan perlindungan, di dalamnya meliputi perjanjian antara kedua belah pihak atau lebih dengan pihak penanggung mengikatkan diri kepada tertanggung dengan menerima premi asuransi, untuk memberikan pergantian kepada tertanggung karena kerugian tertentu. Riset ini mengkaji kepedulian masyarakat terhadap produk-produk asuransi.Penelitian ini dilakukan di Kelurahan Jebres, Kota Surakarta. Penelitian menggunakan 25 responden dengan berbagai latar belakang profesi dan pendidikan. Penelitian menggunakan kuesioner.Hasil penelitian menunjukkan bahwa masyarakat belum memahami dengan baik terkait produk-produk asuransi. Masyarakat menganggap produk asuransi penting, namun masih memiliki keraguan yang cukup tinggi terhadap kemampuan produk asuransi dalam melindungi asset mereka. Rekomendasi yang diberikan dalam peneitian ini ialah memberikan edukasi yang lebih intens terhadap masyarakat terkait produk asuransi.
PERAN PT LINK PASIPIK INDONUSA CABANG SURABAYA DALAM MENANGANI IMPOR PESTISIDA DI JALUR MERAH
Authors: Sambodo Dody , Permata Sari Elizabeth Amalia
Published: April 2024

PT Link Pasipik Indonusa Cabang Surabaya sebagai freight forwarder memiliki peran penting dalam proses impor muatan pestisida di jalur merah. Namun masih ada kendala, antara lain: 1) Pemeriksaan jalur merah yang lama; 2) DO yang expired; 3) Timbulnya SPTNP; 4) Penanganan dangerous goods yang khusus. Sedangkan penelitian ini bertujuan untuk mengetahui pelaksanaan peran PT Link Pasipik Indonusa Cabang Surabaya sebagai freight forwarder dalam memfasilitasi akses impor muatan pestisida di jalur merah, kendala dan upaya mengatasi kendala yang ada.            Penelitian menggunakan pendekatan kualitatif, dengan subyek karyawan bagian operasional impor dan customer service PT Link Pasipik Indonusa Cabang Surabaya yang diperoleh secara purposive sampling. Data diperoleh menggunakan wawancara, observasi dan dokumentasi, yang kemudian dianalisis secara deskriptif kualitatif.            Hasil dari penelitian ini adalah: 1) Peran Freight Forwarding dalam penanganan impor pestisida di jalur merah adalah sebagai perwakilan dari pemilik barang. Freight Forwarding juga berperan untuk menyiapkan dokumen kelengkapan pemeriksaan yang diminta oleh pihak Bea Cukai. 2) Proses penanganan impor adalah serangkaian kegiatan yang sistematis untuk membantu jalannya proses kegiatan impor yang dilakukan oleh pihak-pihak yang berwenang. Penanganan impor barang, khususnya pestisida terdapat proses pengawasan oleh Direktorat Jenderal Bea dan Cukai; 3) Penanganan impor pestisida di jalur merah terdapat kendala, seperti: a) Pemeriksaan jalur merah di Bea Cukai membutuhkan waktu yang cukup lama. Hal ini diatasi dengan melakukan follow up kepada Bea Cukai; b) Delivery Order (DO) yang expired, dapat diatasi dengan meminta free time lebh lama ke pelayaran; c) Timbul SPTNP, dapat diatasi dengan melakukan penyesuaian harga; d) Karena pestisida termasuk ke dalam dangerous goods kelas 6.1, maka dalam penanganannya diperlukan perlakuan yang khusus, antara lain: dalam memindah drum yang berisi pestisida harus hati-hati, tutup yang telah dibuka karena diambil sampelnya harus ditutup dengan rapat, lalu membuka drum yang berisi pestisida harus di ruang tertutup agar terhindar dari matahari.
Edge Effect on Bird Community in Ternate, North Maluku, Indonesia
Authors: Tamnge F , Nurdin A S , Baguna F L , Kurniawan A , Tamrin M , Husen N
Published: April 2024

The edge is a meeting place between two ecosystems, or it can also be interpreted as a boundary where two habitats meet and interact. The presence of edges can create an edge effect and increase richness and species abundance. In the present study, we analyzed how edge and vegetation diversity affect a) bird communities and b) how birds respond to edges. Observation plots were placed in jamblang stands and coconut plantations (edge and interior). Bird communities were observed using point counts with a fixed radius of 25 m, and the distance between plots was 50 m. A survey of vegetation diversity was conducted using a combination of the transect and plot methods. The research showed that the highest species richness and diversity of birds (128 individuals of 18 species) and vegetation (168 individuals of 20 species) were found at the edge, although there were only slight differences in the number of species in each habitat. This was influenced by the structure and composition of the vegetation at the observation site. Nevertheless, this proves that the edge effect shapes the composition of bird communities. There are 9 species of bird can be mapped into 4 response models: generalis neutral, generalist edge exploiter, specialist edge exploiter, and edge specialist.
Public Perceptions on the Importance of Ecosystem Services From Vulnerable Forest: A Case Study of Ampang Forest Reserve, Selangor, Malaysia
Authors:   Universiti Putra Malaysia Faculty of Forestry and Environment, Universiti Putra Malaysia (UPM), 43400 UPM Serdang, Selangor, Malaysia, Gai M Y , Hassan M L , Empidi A V A , Juraimi U F , Noorazman N M , Emang D
Published: April 2024

Forest reserve gazettement affects the sustainability of forests by altering their ecological function and threatening human livelihood. This study examines a recently degazetted forest, using a survey among 120 local respondents living near Ampang Forest Reserve (AFR) in Selangor, Malaysia. The simple random sampling technique was implemented to reduce sampling bias, and descriptive and correlation statistics were used in the analysis. The study aims (i) to examine the public perceived importance of forest ecosystem services from AFR, (ii) to determine public awareness of a range of environmental threat levels towards AFR’s ecosystem services, and (iii) to assess public agreement on conservation measures that could increase protection and ensure the sustainability of ecosystem services from the remaining area of AFR. The result revealed all ecosystem services were perceived as important, and the public was mostly aware of the environmental threats. At the same time, conservation measures should be implemented to protect and ensure the sustainability of ecosystem services from AFR. This study provides insight into public perceptions of the importance of forest ecosystem services derived from vulnerable forest reserves. It indicates the relevance and need for better protection in high-risk forest areas as local livelihood depends on its significant ecological roles.
Carnival Carnivore
Authors: Link David
Published: April 2024

In September 2021, a novel, experimental exhibition took place at Crone Gallery in Vienna, Austria. The artworks shown here were all generated by a precursor of today’s Artificial Intelligence: the text generator Poetry Machine, which David Link has been actively developing since 2001. The article details the texts produced and shows some examples of the artworks in the exhibition. The article thereby practically demonstrates a new approach to curating exhibitions and organizing the workflow between curators, artists and machines.
International economic sanctions in civil international law: a theoretical aspect.
Authors: Butakova Yana Sergeevna
Published: April 2024

Modern international economic sanctions (unilateral restrictive measures) are a unique phenomenon and a vivid example demonstrating how the operation of the norms of private international law can affect the achievement of foreign policy goals. Being a public legal category in its essence, international economic sanctions have a significant impact on private law relations, including relations with a foreign element. Civil law and other relations complicated by a foreign element are subject to the influence of sanctions adopted by the competent authorities of foreign states: contractual, corporate relations, as well as relations within the framework of arbitration, enforcement of foreign court decisions and others. In this regard, private (civil) international law functions as a filter that translates economic sanctions of public law origin into the sphere of private law. Its main task is to choose the applicable law, and conflict of laws rules decide whether a specific international economic sanction applies to contractual relations between the parties or not. The author applies both philosophical and general scientific methods of cognition (analysis and synthesis, induction and deduction, critical and dialectical methods) and methods specific directly to legal science (structural-logical, formal-legal, comparative-legal).The scientific novelty of the research lies in the comprehensive study of international economic sanctions in the context of private and public law. It is precisely private international law that can help to smooth out differences in national judicial practice in cases related to international economic sanctions. The article deals mainly with EU sanctions in the context of private international law, and also provides recommendations for improving and unifying EU sanctions regulation in the context of civil international law. The European sanctions regulation, being one of the most ancient, has a significant amount of judicial practice in the field of application and recognition of sanctions of a foreign state. The study of international sanctions in the context of private law relations can play a significant role in the development of the doctrine of private international law and law enforcement practice.
Current trends in the development of the Intellectual Property Law
Authors: Nechaeva Yulia Sergeevna
Published: April 2024

This article examines the prospects for the development of intellectual property law in national jurisdictions (Russian Federation, Republic of Indonesia, Federative Republic of Brazil, African countries and others), as well as the place of intellectual property in the system of the UN Sustainable Development Goals. The main areas of activity of the World Intellectual Property Organization in the context of achieving these goals, the results of the implementation and use of digital systems and artificial intelligence in the field of intellectual property in national jurisdictions (for example, automation of patent application processes, of document evaluation, of sending documents to the applicant) are analyzed, also the results of the implementation and application of the process of accelerated examination of “green” patents in a number of countries, including the Russian Federation. During the study, general scientific methods were used: analysis, synthesis, logical method, generalization, as well as a special legal method and a comparative legal method. The author came to the conclusion that the introduction of artificial intelligence and digital platforms into the activities of organizations in the field of intellectual property significantly speeds up and simplifies the entire process from filing a patent application to issuing a patent; it is necessary to create a unified database of “green” patents and carry out comprehensive work to popularize activities in the field of environmental inventions, since currently the search for “green” patents issued in Russia is difficult, and in general, environmental inventions in Russia account for only 1% of the total number of inventions; it is necessary to develop interstate cooperation in the field of intellectual property and develop joint projects, since the problems that need to be solved in the process of achieving Sustainable Development Goals are global in nature.
SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells
Authors: Zhang Linda , Hsu Joanne I. , Braekeleer Etienne D. , Chen Chun-Wei , Patel Tajhal D. , Martell Alejandra G. , Guzman Anna G. , Wohlan Katharina , Waldvogel Sarah M. , Urya Hidetaka , Tovy Ayala , Callen Elsa , Murdaugh Rebecca , Richard Rosemary , Jansen Sandra , Vissers Lisenka , de Vries Bert B.A. , Nussenzweig Andre , Huang Shixia , Coarfa Cristian , Anastas Jamie N. , Takahashi Koichi , Vassiliou George , Goodell Margaret A.
Published: April 2024

The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D) is a master negative regulator of the response; gain-of-function mutations and amplifications of PPM1D are found across several human cancers making it a relevant pharmacologic target. Here, we used CRISPR/Cas9 screening to identify synthetic-lethal dependencies of PPM1D, uncovering superoxide dismutase-1 (SOD1) as a potential target for PPM1D-mutant cells. We revealed a dysregulated redox landscape characterized by elevated levels of reactive oxygen species and a compromised response to oxidative stress in PPM1D -mutant cells. Altogether, our results demonstrate the protective role of SOD1 against oxidative stress in PPM1D -mutant leukemia cells and highlight a new potential therapeutic strategy against PPM1D -mutant cancers.
Theory of active self-organization of dense nematic structures in the actin cytoskeleton
Authors: Mirza Waleed , Corato Marco De , Pensalfini Marco , Vilanova Guillermo , Torres-Sànchez Alejandro , Arroyo Marino
Published: April 2024

The actin cytoskeleton is remarkably adaptable and multifunctional. It often organizes into nematic bundles such as contractile rings or stress fibers. However, how a uniform and isotropic actin gel self-organizes into dense nematic bundles is not fully understood. Here, using an active gel model accounting for nematic order and density variations, we identify an active patterning mechanism leading to localized dense nematic structures. Linear stability analysis and nonlinear finite element simulations establish the conditions for nematic bundle self-assembly and how active gel parameters control the architecture, orientation, connectivity and dynamics of self-organized patterns. Finally, we substantiate with discrete network simulations the main requirements for nematic bundle formation according to our theory, namely increased active tension perpendicular to the nematic direction and generalized active forces conjugate to nematic order. Our work portrays actin gels a reconfigurable active materials with a spontaneous tendency to develop patterns of dense nematic bundles.
Mapping the molecular motions of 5-HT3 serotonin-gated channel by Voltage-Clamp Fluorometry
Authors: Peverini Laurie , Shi Sophie , Medjebeur Karima , Corringer Pierre-Jean
Published: April 2024

The serotonin-gated ion channel (5-HT
3
R) mediates excitatory neuronal communication in the gut and the brain. It is the target for setrons, a class of competitive antagonists widely used as antiemetics, and is involved in several neurological diseases. Cryo-electron microscopy of the 5-HT
3
R in complex with serotonin or setrons revealed that the protein has access to a wide conformational landscape. However, assigning known high-resolution structures to actual states contributing to the physiological response remains a challenge.In the present study, we used voltage-clamp fluorometry (VCF) to measure simultaneously, for 5-HT
3
R expressed at a cell membrane, conformational changes by fluorescence and channel opening by electrophysiology. Four positions identified by mutational screening report motions around and outside the serotonin-binding site through incorporation of cysteine-tethered rhodamine dyes with or without a nearby quenching tryptophan. VCF recordings show that the 5-HT
3
R has access to four families of conformations endowed with distinct fluorescence signatures: “resting-like” without ligand, “inhibited-like” with setrons, “pre-active-like” with partial agonists and “active-like” (open channel) with partial and strong agonists. Data are remarkably consistent with cryo-EM structures, the fluorescence partners matching respectively Apo, setron-bound, 5-HT bound-closed and 5-HT-bound-open conformations. Data show that strong agonists promote a concerted motion of all fluorescently labelled sensors during activation, while partial agonists, especially when loss-of-function mutations are engineered, stabilize both active and pre-active conformations.In conclusion, VCF, though the monitoring of electrophysiologically silent conformational changes, illuminates allosteric mechanisms contributing to signal transduction and their differential regulation by important classes of physiological and clinical effectors.High-resolution structures of serotonin-gated receptors (5-HT
3A
R) have evidenced a wide range of conformations that are challenging to annotate to physiologically relevant states. Voltage-clamp fluorometry allows to investigate the activation of 5-HT
3A
R by simultaneously following molecular motions and electrophysiological states at the plasma membrane. Here, we developed four fluorescent sensors reporting conformational changes at the serotonin binding site and at the extracellular domain and transmembrane domain interface. Investigation of a series of agonists, partial agonists and antagonists show that strong agonists promote a concerted motion of the whole protein during activation, while antagonists and partial agonists stabilize distinct closed-channel conformations. Data offer insights into allosteric mechanisms, unravelling the conformational dynamics of the receptors and helping to annotate high-resolution static structures.
Revealing intact neuronal circuitry in centimeter-sized formalin-fixed paraffin-embedded brain
Authors: Lin Ya-Hui , Wang Li-Wen , Chen Yen-Hui , Chan Yi-Chieh , Hu Shang-Hsiu , Wu Sheng-Yan , Chiang Chi-Shiun , Huang Guan-Jie , Yang Shang-Da , Chu Shi-Wei , Wang Kuo-Chuan , Lin Chin-Hsien , Huang Pei-Hsin , Cheng Hwai-Jong , Chen Bi-Chang , Chu Li-An
Published: April 2024

Tissue clearing and labeling techniques have revolutionized brain-wide imaging and analysis, yet their application to clinical formalin-fixed paraffin-embedded (FFPE) blocks remains challenging. We introduce HIF-Clear, a novel method for efficiently clearing and labeling centimeter-thick FFPE specimens using elevated temperature and concentrated detergents. HIF-Clear with multi-round immunolabeling reveals neuron circuitry regulating multiple neurotransmitter systems in a whole FFPE mouse brain, and is able to be used as the evaluation of disease treatment efficiency. HIF-Clear also supports expansion microscopy and can be performed on a non-sectioned 15-year-old FFPE specimen, as well as a 3-month formalin-fixed mouse brain. Thus, HIF-Clear represents a feasible approach for researching archived FFPE specimens for future neuroscientific and 3D neuropathological analyses.
Sensory-memory interactions via modular structure explain errors in visual working memory
Authors: Yang Jun , Zhang Hanqi , Lim Sukbin
Published: April 2024

Errors in stimulus estimation reveal how stimulus representation changes during cognitive processes. Repulsive bias and minimum variance observed near cardinal axes are well-known error patterns typically associated with visual orientation perception. Recent experiments suggest that these errors continuously evolve during working memory, posing a challenge that neither static sensory models nor traditional memory models can address. Here, we demonstrate that these evolving errors, maintaining characteristic shapes, require network interaction between two distinct modules. Each module fulfills efficient sensory encoding and memory maintenance, which cannot be achieved simultaneously in a single-module network. The sensory module exhibits heterogeneous tuning with strong inhibitory modulation reflecting natural orientation statistics. While the memory module, operating alone, supports homogeneous representation via continuous attractor dynamics, the fully connected network forms discrete attractors with moderate drift speed and nonuniform diffusion processes. Together, our work underscores the significance of sensory-memory interaction in continuously shaping stimulus representation during working memory.
Subcortical correlates of consciousness with human single neuron recordings
Authors: Pereira Michael , Faivre Nathan , Bernasconi Fosco , Brandmeir Nicholas , Suffridge Jacob , Tran Kaylee , Wang Shuo , Finomore Victor , Konrad Peter , Rezai Ali , Blanke Olaf
Published: April 2024

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcortical neuronal activity in humans. Here, we asked neurological patients undergoing surgery for deep brain stimulation to detect weak vibrotactile stimuli applied on their hand while recording single neuron activity from the tip of a microelectrode. We isolated putative single neurons in the subthalamic nucleus and thalamus. A significant proportion of neurons modulated their activity while participants were expecting a stimulus. We isolated a subset of neurons for which we had sufficiently good behavior to contrast neuronal activity between detected and undetected stimuli. We found that the firing rate of 23% of these neurons differed between detected and undetected stimuli. Our results provide direct neurophysiological evidence of the involvement of subcortical structures in for the detection of vibrotactile stimuli, thereby calling for a less cortico-centric view of the neural correlates of consciousness.
Staphylococcus aureus counters organic acid anion-mediated inhibition of peptidoglycan cross-linking through robust alanine racemase activity
Authors: Panda Sasmita , Jayasinghe Yahani P , Shinde Dhananjay D , Bueno Emilio , Stastny Amanda , Bertrand Blake P , Chaudhari Sujata S , Kielian Tammy , Cava Felipe , Ronning Donald R , Thomas Vinai C
Published: April 2024

Weak organic acids are commonly found in host niches colonized by bacteria, and they can inhibit bacterial growth as the environment becomes acidic. This inhibition is often attributed to the toxicity resulting from the accumulation of high concentrations of organic anions in the cytosol, which disrupts cellular homeostasis. However, the precise cellular targets that organic anions poison and the mechanisms used to counter organic anion intoxication in bacteria have not been elucidated. Here, we utilize acetic acid, a weak organic acid abundantly found in the gut to investigate its impact on the growth of
Staphylococcus aureus
. We demonstrate that acetate anions bind to and inhibit D-alanyl-D-alanine ligase (Ddl) activity in
S. aureus
. Ddl inhibition reduces intracellular D-alanyl-D-alanine (D-Ala-D-Ala) levels, compromising staphylococcal peptidoglycan cross-linking and cell wall integrity. To overcome the effects of acetate-mediated Ddl inhibition,
S. aureus
maintains a substantial intracellular D-Ala pool through alanine racemase (Alr1) activity and additionally limits the flux of D-Ala to D-glutamate by controlling D-alanine aminotransferase (Dat) activity. Surprisingly, the
modus operandi
of acetate intoxication in
S. aureus
is common to multiple biologically relevant weak organic acids indicating that Ddl is a conserved target of small organic anions. These findings suggest that
S. aureus
may have evolved to maintain high intracellular D-Ala concentrations, partly to counter organic anion intoxication.
Dynamic organization of visual cortical networks revealed by machine learning applied to massive spiking datasets
Authors: Graber Colin , Vlasov Yurii , Schwing Alexander
Published: April 2024

Complex cognitive functions in a mammalian brain are distributed across many anatomically and functionally distinct areas and rely on highly dynamic routing of neural activity across the network. While modern electrophysiology methods enable recording of spiking activity from increasingly large neuronal populations at a cellular level, development of probabilistic methods to extract these dynamic inter-area interactions is lagging. Here, we introduce an unsupervised machine learning model that infers dynamic connectivity across the recorded neuronal population from a synchrony of their spiking activity. As opposed to traditional population decoding models that reveal dynamics of the whole population, the model produces cellular-level cell-type specific dynamic functional interactions that are otherwise omitted from analysis. The model is evaluated on ground truth synthetic data and compared to alternative methods to ensure quality and quantification of model predictions. Our strategy incorporates two sequential stages – extraction of static connectivity structure of the network followed by inference of temporal changes of the connection strength. This two-stage architecture enables detailed statistical criteria to be developed to evaluate confidence of the model predictions in comparison with traditional descriptive statistical methods. We applied the model to analyze large-scale in-vivo recordings of spiking activity across mammalian visual cortices. The model enables the discovery of cellular-level dynamic connectivity patterns in local and long-range circuits across the whole visual cortex with temporally varying strength of feedforward and feedback drives during sensory stimulation. Our approach provides a conceptual link between slow brain-wide network dynamics studied with neuroimaging and fast cellular-level dynamics enabled by modern electrophysiology that may help to uncover often overlooked dimensions of the brain code.
Natural deep eutectic solvents (NADES) for the extraction of bioactives: emerging opportunities in biorefinery applications
Authors: Jauregi Paula , Esnal-Yeregi Leire , Labidi Jalel
Published: April 2024

Natural deep eutectic solvents (NADES) have emerged as an eco-friendly alternative for extracting bioactives, avoiding the use of flammable organic solvents and extreme temperatures and pH conditions. NADES rely on intermolecular interactions between hydrogen bonding donors (HBD) and hydrogen bonding acceptors (HBA) to form eutectic mixtures with significantly lower melting points than their individual components. These matrices are influenced by factors like water content, temperature, and component ratios. NADES high viscosity can hinder extractive efficiency, which can be mitigated by adding water or working at higher temperatures. However, excessive dilution with water may disrupt the supramolecular structure of NADES, reducing extraction efficiency. A notable feature of NADES is their fine-tunability for specific purposes. Adjusting physicochemical properties such as polarity, pH, and viscosity optimizes extraction efficiency by promoting the solubility of target molecules and interactions between the NADES and target molecules. NADES, unlike organic solvents, can partially disrupt plant and microalgae cell walls, enhancing permeability and extraction efficiency. Moreover, NADES can have a stabilising effect on bioactives and can enhance their biological activity and bioavailability. These attributes, coupled with their low environmental impact in terms of low toxicity and high biodegradability, make NADES attractive for biorefinery applications.
Modelo multicriterio para a gestão de estoques utilizando a classificação ABC e o método TOPSIS
Authors: Brito Jafter Raphael Ferreira de , Galo Nadya Regina
Published: April 2024

As empresas estão vivenciando um momento de constante competitividade, o que acarreta desafios para se destacarem no mercado e obter resultados financeiros satisfatórios. Em meio a alta concorrência, uma questão essencial é realizar a gestão de estoques de forma eficiente, por possibilitar obter vantagens competitivas e impactar diretamente na rentabilidade da empresa. Para o alcance de uma gestão eficiente, torna-se necessário o uso de ferramentas e métodos de auxílio. Com isso, este artigo possui o objetivo de apresentar a ferramenta curva ABC e analisar suas contribuições, como forma de auxiliar os gestores na tomada de decisão. Para tanto, foi realizada uma modelagem quantitativa empírica em uma empresa que atua no segmento de tecnologia Telecom localizada em Goiânia-GO, onde foi realizada a classificação ABC para o estoque não operacional e, em um segundo momento aplicação do método TOPSIS em seus respectivos componentes da lista oriundo da classificação com objetivo de mapear oportunidades que não são possíveis apenas com a classificação ABC, houve sucesso na aplicação de ambos os métodos, onde a organização consegue realizar a gestão do estoque e de compras de forma estratégica, evitando excesso de produtos em estoques.
Therapeutic with Obstetrical Management to Deliver Live Three Male Foetuses in a Surti Doe
Authors: Kalaswa Sachin , Jadav Ravindra , Keshav . , Solanki Vipul , Panchal Janak , Nakhashi H. C. , Suthar B. N.
Published: April 2024

Dystocia is common occurrence in small ruminants like goat and sheep. A case tentatively diagnosed as a foetal dystocia due to foetal dorso-pubic position and malpostures of foetus in seven year old surti doe based on the history, clinical signs and vaginal examination. The present case described a successful delivery of three live male foetuses by obstetrical mutational approach following therapeutically intravenous administration of 20IU- Oxytocin, 30ml-calcium borogluconate and 500ml Normal saline, whereas 5ml valethamate bromide and antihistamine were administered intramuscularly. Supportive therapy various fluids, analgesic, antibiotic and intra-uterine pessaries, resulted a affected Surti doe to normal health within few days.