bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of primary debulking surgery and neoadjuvant chemotherapy plus interval debulking surgery for epithelial ovarian cancer with extra-abdominal metastasis
Authors: Jiang Qidi , Zou Ruoyao , Chen Mo , Yuan Lei , Bao Yiting , Yao Liangqing
Published: January 2023

Background

Primary debulking surgery (PDS) or neoadjuvant chemotherapy with interval debulking surgery (NACT-IDS) was the standard treatment for advanced ovarian cancer. Optimal cytoreduction is believed one of the most important factors for survival. However, in patients with extra-abdominal metastases which is impossible to achieve optimal cytoreduction around whole body, which treatment should be used is not clear yet.

Methods

Patients with stage IV epithelial ovarian cancer with extra-abdominal metastases who underwent primary treatment between January 1, 2015 and January 31, 2022 were identified. Data were retrospectively extracted. Each patient record was evaluated to subclassify stage IV disease according to the sites of metastases at the time of diagnosis. Kaplan-Meier plot and Log-rank test were used to analyze the difference between two groups. Univariate and multivariate Cox regression analysis were used to identify important prognostic factors.

Results

A total of 72 newly diagnosed stage IV epithelial ovarian cancer patients were included, in which 36 (50%) patients underwent PDS, 36 (50%) patients underwent NACT-IDS. The median overall survival was significantly longer in PDS group than NACT-IDS group (51.3 months vs. 36 months, p = 0.027). Patients receiving PDS has significantly longer progression-free survival than who received NACT-IDS (21.6 months vs. 14.3 months, p = 0.049). The rate of no residual disease was higher in patients with NACT-IDS versus PDS (61% vs. 44%). The complete response rate was significantly higher in PDS group than NACT group (83% vs. 67%, p = 0.013) after PDS/IDS and full course of chemotherapy. Women who received PDS had a trend toward a higher rate of grade III/IV postoperative complications than those who received NACT (25% vs. 6%, p = 0.046).

Conclusions.

PDS for epithelial ovarian cancer patients with extra-abdominal metastasis resulted in longer OS and PFS than NACT + IDS. Cytoreduction to no residual disease in the interval debulking surgery should be the goal in patients who receive NACT.
Using rice bran for encapsulating probiotic and by different methods to produce synbiotic powder which can be tolerance gastrointestinal condition, application in health products.
Authors: Tianwitawat Chanika , Klaiprasitti Patimakorn
Published: January 2023

Several consumers who have been interested in Lactic acid bacteria for healthy food are higher due to awareness of the probiotic’s role. Several studies have presented stress adaptation of single probiotic strains, but the comparison of stress-tolerant capacity between probiotic strains have not been completely investigated. Five lactic acid cultures were tested for adaptation in four sub-lethal conditions, including heat, cold, acidity and bile salt. Lactobacillus casei is found to be the most resilient probiotic from heat and cold adaptation, while Lactobacillus acidophilus is more tolerant to low acid and bile salt. Then these probiotics were subjected to the stress challenge that stimulated drying temperature, inclusive of heat challenge at 72°C for 15 seconds and cold challenge at -60°C for 48 hours. The results showed that acid adaptation can improve Lactobacillus acidophilus TISTR 1338 as the highest tolerance for both harsh drying temperature due to the major brand protein involved in stress adaptation that are DnaK and GrpE. Acid-adapted L. acidophilus TISTR 1338 at the sub-lethal is able to be applied to high and low temperature processing. In addition, it was found that the encapsulation using prebiotic extracts from rice bran combined with pectin and resistant starch in the crosslinking technique treated by freeze-drying method provides the highest encapsulation efficiency or more than 90%. Also, the amount of survivable probiotic after via gastrointestinal tract remained 5 LogCFU/g, which is suitable for application in the production of synbiotic cold brew coffee.
Nd:YAG 1064-nm laser for residual infantile hemangioma after propranolol treatment
Authors: Khamaysi Ziad , Pam Nadav , Zaaroura Hiba , Avitan-Hersh Emily
Published: January 2023

Background:Infantile hemangiomas (IH) arecommon benign tumors of infancy. Most IH involute, either spontaneously, or secondary to pharmacological treatment with systemic propranolol. Propranolol treatment mostly leads to regression of hemangiomas with satisfactory aesthetic results, but unfortunately not in all cases.Objective:To assess the safety and efficacy of long pulsed Nd:YAG 1064 nm laser in treating patients with residual infantile hemangioma after systemic propranolol treatment.Patients and methods:This is an open-label prospective cohort study. 30 patients with focal residual IH that had sub-optimal responses to systemic propranolol treatment were enrolled in the study. The patients were treated with 1 to 3 sessions with long pulsed Nd: YAG 1064 nm laser. The maximal response of the IH was assessed using a 4-point scale evaluation scale system.Results:Of the 30 patients enrolled, 18 patients exhibited a great response (>76% improvement), 10 patients had a good response (>51-75% improvement), while only 2 patients showed a moderate response (<50% improvement) to the treatment. No patients had an unsatisfactory response. No serious side effects were observed, and only minor side effects were reported.Conclusions:The treatment with long pulsed Nd:YAG 1064 nm laser for residual IH, which were resistant to systemic propranolol treatment, is safe and effective. Thus, we suggest its use as a second-line treatment for patients with sub-optimal aesthetic results following systemic propranolol.
The Evaluation of Pre-Extubation Vital Signs as Indicators for Extubation Failure in ICU Patients
Authors: Schwier Corrine P , Ozaki Haruka
Published: January 2023

Objective:

This retrospective study analyzes patient vital sign averages during intubation and compares them to 1-hour pre-extubation vital sign averages. Data from 7,185 ICU admissions were compiled from the MIMIC-IV database. Vital signs include heart rate, systolic and diastolic blood pressure, respiratory rate, blood oxygen level (SpO2), temperature, and glucose levels.

Results:

There were significant differences between the extubation success (ES) and failure (EF) groups both in their intubation averages and 1-hour pre-extubation averages. ES patients’ respiratory rates increased 1-hour prior to extubation, while EF patients did not demonstrate a marked change. In combination with decreased SpO2, the lack of change in respiratory rate can be a good indicator that a patient experience EF.
The results of this study suggest that there are marked changes in patient vital signs 1-hour pre-extubation compared to their total intubation averages between patients that are successfully extubated and those that require reintubation.
Trends and age-period-cohort effect on dental caries prevalence from 2008 to 2019 among Brazilian pre-school children
Authors: Ramadan Yassmín Hêllwaht , Knorst Jessica Klöckner , Brondani Bruna , Agostini Bernardo Antonio , Ardenghi Thiago Machado
Published: January 2023

Aim: This study aimed to evaluate trends in the prevalence of dental caries in preschool children and associated factors considering different time variations.
Methods: This is a time seriesstudy performed using data from three cross-sectional studies with pre-school children from southern Brazil in 2008, 2013 and 2019. Dental caries was evaluated by decayed, missing and filled deciduous teeth (dmft index). Demographic, socioeconomic, behavioural and psychosocial variables were also collected. Chi-square test for trends and a hierarchical age-period-cohort (HAPC) analysis using multilevel Poisson regression model for testing the associations between predictor variables and dental caries experience were used.
Results: A total of 1,644 pre-school children participated in all surveys. There was a significant difference in caries experience considering all APC effects. The prevalence of dental caries was 25.0% in 2008, 16.3% in 2013, and 19.4% in 2019 and no statistical difference was observed. An age effect showed that older children were more likely to experience dental caries. Considering the cohort effect, there is a significant difference between the generations, mainly between 2003 and 2018. Household income, use of dental services, and parent’s perception of child oral health were associated with dental caries experience no matter the time variation.
Conclusion: Despite recent declines in dental caries prevalence among preschool children, caries levels increased with age and social inequalities persisted through the years, indicating a need of reviewing the policies to reduce the burden of this oral disease.
Clinical relevance: Our findings reinforce that the common risk factors still represent the best predictor for dental caries trends.
Effect of methyl orange and Evans blue functional groups on photocatalytic activities of different magnetite nanoparticle surfaces
Authors: Ahmouda Kaouthar , Boudiaf Moussa , Barani Djamel
Published: January 2023

The aim of this paper is to study the effect of Evans blue (EB) and methyl orange
(MO) functional group contents on the photocatalytic activities of four magnetite nanoparticle surfaces under UV-Vis (365 nm) in ambient conditions against the photodegradation of EB and MO. For this purpose, the adsorption has been conducted, at first, in dark ambient conditions to eliminate the effect of adsorption. The residual solutions of dye/magnetite were then used for photocatalytic reactions of the free functional groups of MO and EB on the four magnetite surfaces. The novelty of this paper lies in the demonstration of the effect of EB and MO functional groups on photocatalytic activities of magnetite nanoparticles (NPs) through the electron-hole pair’s interactions with dyes functional groups translated by the photoactivation of the Br ̈onsted and Lewis acid sites on the magnetite NPs. The results found show that MO photodegradation capacities and rates are higher than those of EB on the four magnetite surfaces, this is probably due to a large number of chromophores and auxochromes present in MO initial residual solutions. This is related to the effect of chromophore and auxochrome contents on the photoactivation of Br ̈onsted and Lewis acid sites. High chromophore and auxochrome contents in MO residual solutions further promote the photoactivation of Br ̈onsted and Lewis acid sites, resulting in the greater formation of trapped-electron and trapped-hole sites. The latter will then photoreduce more chromophores and photooxidize more auxochromes, respectively, which leads to an increase in the photocatalytic activity of magnetite surfaces.
The expression of Galectins-8 and its effect on neuroinflammation after intracerebral hemorrhage
Authors: JingjingSong  , JiyuLou  , ChaoJiang  , HongyingBai  , SiChen  , YuanyuanXing
Published: January 2023

At present, there is no effective treatment for secondary brain injury caused by spontaneous intracerebral hemorrhage (ICH). This study aims to explore new therapeutic targets after ICH. Galectins-8 is a tandem repeat galectin with a unique preference for α2,3-sialylated glycans, and its expression is ubiquitous. Gal − 8 regulates cytokine production, cell adhesion, apoptosis, chemotaxis, endocytosis, differentiation and migration, including immune cells. We used wild-type(WT)C57BL/6J mice and the mice of Galectins-8 gene knockout to establish intracerebral hemorrhage model by collagenase injection and found that Galectins-8 was highly expressed around the hematoma and in the center site of the hematoma after intracerebral hemorrhage. We also found that inhibiting the expression of Galectins-8 or Galectins-8 gene knockout mice may attenuate secondary brain injury following intracerebral hemorrhage by reducing microglia-induced inflammatory responses. Galecectin-8 knockout mice had significantly reduced expression of inflammatory factors, such as TNF-α(P = 0.0353), MCP-1(P = 0.0469), and HMBG1(P = 0.0466). This is in contrast to previous studies that have suggested Galectins-8 as a neuroprotective factor. From this, we draw a conclusion that Galectins-8 played an crucial role in regulating the inflammatory response during intracerebral hemorrhage. Our study highlights Galectins-8 as a potential therapeutic target to protect the brain against secondary brain damage during intracerebral hemorrhage.
A Rare Case of Urethral Tuberculosis
Authors: Kholtobin D. P. , Kulchavenya E. V.
Published: January 2023

Urethral tuberculosis is a rare disease since the advent of highly effective anti-tuberculosis drugs. The article describes an extremely rare clinical observation of a 34-year-old patient with the transition of tuberculous inflammation from the subcutaneous tissue to the wall of the urethra with intact kidneys. Since the first blood discharge from the urethra, the diagnostic process took 3.5 years, all these years, multiple examinations for tuberculosis were carried out and the results were negative, while the disease progressed. The diagnosis was differentiated between acute purulent anterior subcutaneous paraproctitis and festering pararectal cyst. There were repeated openings of the perineal abscess, no bacterial growth was observed, histological tests revealed chronic purulent inflammation. In view of the persistent recurrent course of perineal abscess, tuberculosis was repeatedly suspected. Acid-resistant mycobacteria were found in the discharge from the fistula by fluorescent microscopy: 10-99 in the sample. Tuberculous mycobacteria were not found in the urine by polymerase chain reaction. The patient was diagnosed with A18.4. Tuberculosis of subcutaneous fat (perineum). Mycobacterium tuberculosis (+). The course of disease was complicated by perineal fistula. With the anti-tuberculosis treatment, the fistulous opening healed within a month.
An Overview of Cyclophosphamide Development and Clinical Applications
Authors: Colvin O. M.
Published: January 2023

In this overview of the pharmacology of the anticancer dru!:'. cyclophosphamide, a brief history of the development of this drug from the gener,11 class of nitrogen mustards is provided. The antitumor activity of cyclophosphamidc and its isomer ifosfamide is discussed through considerations of metabolism. resistance, detoxification, and DNA cross-linking. Clinical uses in general chemotherapy, bone marrow transplantation and immunosuppression are presented. A review with 73 references.
Mechanisms of Resistance to the Toxicity of Cyclophosphamide
Authors: Gamcsik Michael P. , Dolan M. Eileen , Andersson Borje S. , Murray David
Published: January 2023

Resistance to cyclophosphamide therapy continues to be a major reason for treatment failure. This chapter covers some of the mechanisms implicated in resistance to the toxic and mutagenic effects of cyclophosphamide therapy in the laboratory and clinic. Since resistance is likely to be the result of a number of interrelating factors, this chapter evaluates the contribution of both glutathione and DNA repair processes to cyclophosphamide resistance. Glutathione appears to be involved directly in the detoxification of cyclophosphamide and metabolites and may play a more indirect role in other processes. The ability of the cell to repair cyclophosphamide-induced DNA lesions, possibly through nucleotide excision repair or other processes, may be a key contributor to drug resistance. Interestingly, the presence of the repair enzyme, 06-alkylguanine-DNA alkyltransferase, long thought to be involved with resistance to methylating and chloroethylating agents, may also contribute to resistance to the cytotoxic and mutagenic effects of cyclophosphamide.
CSa Receptor Antagonists
Authors: Pellas Theodore C. , Wennogle Lawrence P.
Published: January 2023

The anaphylatoxin C5a is an extremely potent proinflammatory peptide produced during activation of the complement system. The structure of C5a includes a 'core' region (N-terminal residues 1-63) consisting of four, antiparallel alpha­ helices held together by three disulfide linkages and a structured C-terminal 'tail' (residues 64-74). The C5a receptor belongs to the large class of seven transmembrane, G-protein-linked receptors. C5a appears to interact with its receptor
at two sites: the C5a core binds to the receptor's N-terminal extracellular domain while C5a's tail binds the receptor near Arg206, near the membrane surface of transmembrane helix V. C5a receptors are concentrated on blood granulocytes (neutrophils, eosinophils, and basophils) and tissue inflammatory cells (macrophages, mast cells, microglia); thus the main effects of C5a are manifest as inflammation. Additionally, C5a receptors are also present, albeit in lower concentrations, on non-myeloid cells, e.g. endothelial and smooth muscle cells where they may further influence inflammatory reactions such as blood cell emigration and tissue edema. C5a has been implicated in myriad disorders, both acute and chronic; therefore a C5a receptor antagonist is predicted to have utility as a therapeutic agent. Unfortunately, few specific C5a receptor antagonists have been reported, and only two have demonstrated activity in vivo. Furthermore, those reported are peptidic and hence have limited application therapeutically. The current state of C5a receptor antagonists is discussed as well as the potential for their use against various human disorders. A model of C5a receptor dimerization is presented to account for the high potency of the disulfide antagonist C5aRAD.
Identifying Diagnostic Biomarkers of Breast Cancer Based on Gene
Expression Data and Ensemble Feature Selection
Authors: Li Lingyu , Algabri Yousif A. , Liu Zhi-Ping
Published: January 2023

Background:

In recent years, the identification of biomarkers or signatures based on gene expression profiling data has attracted much attention in bioinformatics. The successful discovery of breast cancer (BRCA) biomarkers will be beneficial in reducing the risk of BRCA among patients for early detection.

Methods:

This paper proposes an Ensemble Feature Selection method to screen biomarkers (abbreviat-ed as EFSmarker) for BRCA from publically available gene expression data. Firstly, we employ twelve filter feature selection methods, namely median, variance, Chi-square, Relief, Pearson and Spearman correlation, mutual information, minimal-redundancy-maximal-relevance criterion, ridge regression, decision tree and random forest with Gini index and accuracy index, to calculate the importance (weights or coefficients) of all features on the training dataset. Secondly, we apply the logistic regres-sion classifier on the test dataset to calculate the classification AUC value of each feature subset indi-vidually selected by twelve methods. Thirdly, we provide an ensemble feature selection method by ag-gregating feature importance with classification AUC value. In particular, we establish a feature im-portance score (FIS) to evaluate the importance of each feature underlying all feature selection methods. Finally, the features with higher FIS are taken as identified biomarkers.

Results:

With the direction of the FIS index induced by the EFSmarker method, 12 genes (COL10A1,
COL11A1, MMP11, LOC728264, FIGF, GJB2, INHBA, CD300LG, IGFBP6, PAMR1, CXCL2 and
FXYD1) are regarded as diagnostic biomarkers for BRCA. Especially, COL10A1, ranked first with a
FIS value of 0.663, is identified as the most credible biomarker. The findings justified via gene and protein
expression validation, functional enrichment analysis, literature checking and independent dataset
validation verify the effectiveness and efficiency of these selected biomarkers.

Conclusion:

Our proposed biomarker discovery strategy not only utilizes the feature contribution but also considers the prediction accuracy simultaneously, which may also serve as a model for identifying unknown biomarkers for other diseases from high-throughput gene expression data. The source code and data are available at https://github.com/zpliulab/EFSmarker.
Bio-Inspired Dioxygen Activation and Catalysis By Redox Metal Complexes
Authors: Liao Guangjian , Yin Guochuan
Published: January 2023

In nature, redox enzymes mediated dioxygen activation with oxidations
proceeds smoothly and highly selectively under ambient temperature, whereas in the
chemical industry, versatile oxidations are commonly performed at elevated
temperature, which leads to the occurrence of radical chain process, thus causing low
product selectivity and environmental pollution. This chapter will first introduce the
strategies of enzymes including P450s, methane monooxygenase, dioxygenases in
dioxygen activation and catalysis, thus illustrating how enzymes activate dioxygen and
selectively transfer the resulting active oxygen to their substrates. Then, inspired by
enzymatic dioxygen activation, the progress in biomimetic dioxygen activation with
related catalytic oxidations by synthetic redox metal complexes will be presented, and
its current challenges will be discussed as well. Finally, a recent new strategy for
dioxygen activation and catalysis, that is, Lewis acid promoted dioxygen activation by
redox metal complexes, will be introduced; this new strategy may have more closely
biomimicked enzymatic dioxygen activation than those traditional strategies, thus
shedding new light on catalyst design for industrial oxidations.
Regional Comprehensive Economic Partnership (RCEP) and ASEAN Sustainable Development Goals
Authors: Gweshengwe Blessing
Published: January 2023

An economic partnership can play a significant role in poverty reduction in
the countries involved. The partnership’s contribution to poverty alleviation is,
however, a function of its scope and the nature of participating countries, which could
be constrained by various factors. Considering this, the chapter addresses the question
of whether the RCEP can contribute meaningfully to the achievement of the UN
Sustainable Development Goal 1 within the ASEAN region. This aspect is yet to be
subjected to scholarly examination. The chapter examines the potential of the RCEP to
help ASEAN countries to eradicate poverty, the factors that could jeopardise this
endeavour and the measures that could be taken to address these factors. Findings show
that the RCEP could indeed contribute to the realisation of Sustainable Development
Goal 1 in ASEAN countries since it has the potential to contribute to poverty
eradication. This is because of the partnership’s capacity to, among other aspects, drive
economic growth, boost real convergence and optimise the poverty eradication
potential of Micro, Small and Medium Enterprises in the ASEAN region. This
contribution may, however, be jeopardised with the advent of adverse events like the
COVID-19 pandemic, and because of political instability in some ASEAN countries. In
order to mitigate the impact of both of these challenges, ASEAN countries could
reinforce their social protection systems, intensify their commitment to the RCEP and
address the needs of the losers in the RCEP.
Validasi Data Curah Hujan PERSIANN (Precipitation Estimation from Remotely Sensed Information Using Artifial Neural Networks) dengan Pos Stasiun Hujan di DAS Selorejo
Authors: Patabang Steven Tandi , Harisuseno Donny , Fidari Jadfan Sidqi
Published: January 2023

Kehilangan data hujan serta persebaran pos stasiun hujan yang kurang merata menjadi permasalahan yang sering dijumpai di lapangan, namun nyatanya data hujan yang lengkap serta akurat sangat dibutuhkan dalam analisa hidrologi untuk mendapatkan hasil yang maksimal. Seiring kemajuan teknologi data hujan berbasis satelit bisa menjadi solusi dari permasalahan tersebut. Salah satu data curah hujan berbasis satelit yang bisa digunakan ialah satelit PERSIANN. Sebelum digunakan, data curah hujan PERSIANN harus divalidasi terlebih dahulu untuk mengetahui apakah datanya menggambarkan data di lapangan. DAS Selorejo merupakan lokasi yang digunakan dalam studi ini karena dianggap mempunyai data yang lengkap dan dapat diandalkan. Analisa validasi dalam studi ini dilakukan dengan dua cara yaitu memvalidasi data curah setiap pos stasiun serta memvalidasi data curah hujan dalam bentuk rerata daerah. Metode yang digunakan dalam analisa validasi ialah Root Mean Squared Error (RMSE), Nash Sutcliffe Efficiency (NSE), Uji Kesalahan Relatif (KR), serta Koefisien Korelasi (R). Data yang telah divalidasi selanjutnya di lakukan analisa kalibrasi untuk mengoreksi data serta analisa verifikasi untuk mengetahui perbandingan data yang belum dikoreksi dengan data yang telah dikoreksi. Hasil dari analisa ini menunjukkan data hujan satelit yang telah dikoreksi lebih baik dibandingkan data yang belum dikoreksi melalui nilai RMSE serta KR yang semakin menurun, nilai NSE meningkat serta nilai R yang cenderung stabil. Dapat disimpulkan data PERSIANN dapat digunakan sebagai data hujan alternatif di DAS Selorejo.
Perbandingan Metode Alih Ragam Hujan Menjadi Debit dengan FJ. Mock dan NRECA di DAS Gandong Kabupaten Magetan
Authors: Nurviana Syelawati Citra Kartika , Suhartanto Ery , Harisuseno Donny
Published: January 2023

Proses pengalihragaman hujan ke debit yang berlokasi di DAS Gandong dilaksanakan memakai metode FJ. Mock dan NRECA. Setelah itu dilakukan uji kalibrasi dan validasi memakai data debit (AWLR) terhadap debit hasil permodelan untuk mengetahui metode mana yang memiliki kesesuaian dengan karakter dari DAS Gandong. Hasil terbaik pada penelitian ini adalah Metode NRECA dengan nilai ketika proses kalibrasi terbaik periode 8 tahun menghasilkan nilai MAE = 0.029, NSE = 0.982, R = 0.992, Kr = 1.11%.Â Ketika proses validasi terbaik periode 1 tahun menghasilkan nilai MAE = 0.100, NSE = 0.857, R = 0.942, Kr = 5.15% dengan nilai parameter PSUB = 0.98, GWF = 0.0001â€“0.003, koefisien reduksi = 0.9, W0 = 1218.87 mm, nilai tampungan air tanah awal = 200 mm. Serta untuk metode FJ. Mock didapatkan kalibrasi terbaik periode 7 tahun menghasilkan nilai MAE = 0.020, NSE = 0.993, R = 0.997, Kr = 0.69%. Dan validasi terbaik periode 2 tahun menghasilkan nilai MAE = 0.787, NSE = -29.048, R = 0.405, Kr = 95.21% dengan nilai parameter m = 30%-50%, i = 0.9, k = 0.034â€“0.988, SMC = 200 mm, ISM = 100 mm, Vn-1 = 100 mm.
Analisa Indeks Kinerja Sistem Irigasi DI Amandit Kabupaten Hulu Sungai Selatan dengan Menggunakan Epaksi
Authors: Kresnanto Ilham Adi , Wahyuni Sri , Fidari Jadfan Sidqi
Published: January 2023

Daerah Irigasi Amandit adalah satu daerah irigasi dalam kewenangan pusat dengan luasan 5472 Ha yang berada di Kabupaten Hulu Sungai Selatan. Meskipun berada dalam kewenangan pusat, daerah irigasi ini memiliki beberapa permasalahan terutama kurangnya personil dalam pelaksanaan O&P. Oleh karena itu diperlukan perhitungan kebutuhan personil optimal dan juga penilaian indeks untuk kinerja irigasi untuk mempertahankan kondisi dan fungsi aset. Nilai Indeks Kinerja Sistem Irigasi (IKSI) untuk Daerah Irigasi Amandit adalah sebesar 64,39% (Kondisi Kurang) dengan nilai pada aspek prasarana fisik 29,05%, aspek produktivitas tanam 10,96%, aspek sarana penunjang O&P 7,58%, aspek organisasi personalia 8,54%, aspek dokumentasi 2,70% dan aspek P3A sebesar 5,56%. Tetapi secara keseluruhan kondisi aset yang ada pada Daerah Irigasi ini memiliki kondisi dengan nilai sedang berdasarkan hasil nilai kondisi fisik bangunan rata-rata yakni sebesar 76,72% dan nilai kondisi fisik saluran rata-rata yakni sebesar 74,48%. Untuk perhitungan AKNOP atau Angka Kebutuhan Nyata untuk Operasi dan Pemeliharaan untuk Daerah Irigasi Amandit termasuk dengan 5 bangunan rekomendasi yang memiliki nilai jelek ialah sebesar Rp. 2.104.942.125.
Analisis Stabilitas Perkuatan Lereng Sungai Jatiroto Bagian Hulu Kabupaten Lumajang dengan Menggunakan Software Geostudio
Authors: Putra Andaru Rahman , Asmaranto Runi , Suprijanto Heri
Published: January 2023

Peningkatan curah hujan dan debit air di area sungai Jatiroto, Kabupaten Lumajang berpotensi menyebabkan banjir dan tanggul runtuh. Penelitian yang dilakukan bertujuan untuk merencanakan tanggul parapet guna mengurangi dampak banjir dan kerusakan tanggul. Studi analisis debit banjir rancangan dilakukan dengan menggunakan metode HSS Nakayasu. Analisis hidraulis dilakukan dengan menggunakan program HEC-RAS 5.0.7 agar mengetahui kondisi existing dan menentukan lokasi tanggul parapet. Perencanaan tanggul menggunakan Q25 tahun sebagai dasar yaitu sebesar 461,49 m3/detik. Perhitungan stabilitas dilakukan dengan menggunakan bantuan program Geostudio 2018. Hasil perencanaan didapatkan untuk tanggul A tinggi 2 m, lebar 1,4 m, kedalaman pondasi 0,25 m. Sementara di tanggul B tinggi 4 m, lebar 2,8 m, kedalaman pondasi 0,5 m. Perencanaan tanggul C tinggi 4 m, lebar 2,8 m, kedalaman pondasi 0,5 m. Dengan hasil aman terhadap segala kondisi.
Evaluasi Kerentanan Air Tanah Dangkal dengan Menggunakan Metode GOD dan Metode Galdit (Studi Kasus di Kecamatan Bangil Kabupaten Pasuruan)
Authors: Putri Anthea Alviona , Siswoyo Hari , Yuliani Emma
Published: January 2023

Kecamatan Bangil merupakan salah satu kecamatan yang berada di Kabupaten Pasuruan yang mengalami pertumbuhan penduduk dan industri yang cukup padat. Hal tersebut berdampak pada penggunaan air tanah yang semakin intensif dan meningkatnya produksi air limbah, sehingga dikhawatirkan akan mengakibatkan pencemaran kualitas air tanah. Studi ini bertujuan untuk menentukan nilai parameter-parameter yang akan memberikan besar nilai indeks metode GOD dan GALDIT pada air tanah dangkal, lalu hasil nilai indeks metode GOD dan GALDIT dibandingkan dengan metode AVI, serta memetakan pola sebaran kerentanan air tanah berdasarkan nilai indeks ketiga metode. Data diukur menggunakan rollmeter, GPS Garmin 60, pH meter, dan thermometer digital. Hasil pengukuran nilai indeks metode GOD pada 7 titik sumur bernilai 0,3, sedangkan 21 titik sumur lainnya bernilai 0,4 dan 0,5 dan nilai indeks metode GALDIT pada 23 titik sumur bernilai 3,0-4,8, sedangkan 5 titik sumur lainnya bernilai 5-5,7. Hasil pengukuran metode GOD dan GALDIT memiliki tingkat kerentanan rendah dan sedang, sedangkan metode VIF memiliki tingkat sangat tinggi pada seluruh titik. Berdasarkan hasil pengukuran, ketiga metode dapat digunakan untuk mengidentifikasi kerentanan pada tiap lokasi sumur.
Studi Penanggulangan Banjir Dengan Upaya Normalisasi Pada Sungai Sragi Baru Kabupaten Pekalongan Provinsi Jawa Tengah
Authors: Roosydi Yayan Ishad , Priyantoro Dwi , Sisinggih Dian
Published: January 2023

Sungai Sragi Baru berlokasi di Kabupaten Pekalongan, Provinsi Jawa Tengah dengan Panjang sungai utama 60 km. Sungai ini berada pada DAS Sragi Baru dengan luas 254 km2. Kapasitas penampang Sungai Sragi Baru kurang memadai karena akibat dari pengaruh sedimentasi. Pada studi ini, hal yang pertama dilakukan adalah menganalisis debit banjir rancangan, dan melakukan pemodelan menggunakan HEC-RAS 5.0.7 dengan debit banjir rancangan yang telah dianalisis sebesar 644.465 m3/dt. Perencanaan kapasitas penampang mempertimbangkan konsentrasi muatan debris dalam debit aliran, sehingga debit rencana QP = 1,1 Ã— Q25th = 708,912 m3/dt. Perbaikan penampang sungai dilakukan dengan penampang ganda berbentuk trapesium dengan kemiringan talud 1:1,5, dan menghilangkan endapan yang terjadi sehingga koefisien kekasaran Manning berubah menjadi 0,018, dan kemiringan memanjang sungai direncanakan 0,00027. Lalu untuk tanggul urugan tanah direncanakan dengan tinggi jagaan 1 m, lebar mercu 4 m, dan kemiringan 1:1,5. Selanjutnya dilakukan analisis sedimentasi. Pengaruh sedimentasi pada Sungai Sragi Baru mengakibatkan kondisi rawan banjir yang akan terjadi setelah 20 tahun. Dalam hal ini, volume endapan yang dihasilkan sebesar 299.667,311 m3, dan slope menjadi 0.000304. Oleh karena itu, perlu dilakukan kegiatan normalisasi sungai berupa pengerukan dasar sungai untuk mengembalikan kapasitas penampang agar mampu mengalirkan debit banjir rencana (Qp = 708,912 m3/dt).
STUDI MANAJEMEN KONSTRUKSI REHABILITASI SALURAN IRIGASI MRICAN KABUPATEN JOMBANG DENGAN METODE FASTTRACK DAN CRASHING
Authors: Firdaus Adam Wahyu , Juwono Pitojo Tri , Cahya Evi Nur
Published: January 2023

Kegiatan rehabilitasi bertujuan untuk menunjang suatu produktivitas bagi pertanian yang berfungsi sebagai penjaga ketahanan pangan nasional. Dalam kegiatan rehabilitasi tidak terlepas dari target waktu dan biaya, sehingga diperlukan analisa manajemen konstruksi yang baik agar tidak terjadi keterlambatan. Tujuan dari penelitian ini untuk mengatasi keterlambatan pada kegiatan rehabilitasi dengan mengoptimasi penjadwalan pada proyek menggunakan metode percepatan. Pada penelitian ini ada dua metode optimalisasi yang dapat dilakukan pada proyek rehabilitasi Saluran Irigasi Mrican. Dua metode optimalisasi yang dapat digunakan yaitu metode fasttrack dan crashing. Metode fasttrack yaitu metode dengan melakukan dua pekerjaan secara bersamaan atau paralel yang menyebabkan produktivitas pekerja per hari menjadi meningkat dengan jumlah tenaga kerja dan alat berat yang tetap, sehingga dapat mempercepat durasi dari dua pekerjaan yang dilakukan. Cara yang kedua adalah menggunakan metode crashing dengan melakukan penambahan jumlah sumberdaya dimana penambahan jumlah sumberdaya yang dilakukan hanya pada kegiatan-kegiatan yang ada pada lintasan kritis proyek sehingga dapat mempercepat penyelesaian dari keseluruhan proyek. Dari hasil optimasi dengan menggunakan dua metode tersebut didapatkan hasil efektivitas dari segi waktu sebesar 8,63% dan efisiensi biaya sebesar 3,33% untuk metode fasttrack, sedangkan efektivitas dari segi waktu sebesar 10,66% dan efisiensi biaya sebesar 2,92% untuk metode crashing.
Identifikasi Karakteristik Fisik Dan Mineralogi Tanah Dan Batuan Material Longsoran Di Kecamatan Tugu Kabupaten Trenggalek
Authors: Prasetyo Erinna Melina , Hendrawan Andre Primantyo , Yuliani Emma
Published: January 2023

Kabupaten Trenggalek, Provinsi Jawa Timur terletak pada koordinat 111Âº 24â€™ - 112Âº 11â€™ BT dan 7Âº 63â€™ - 8Âº 34â€™ LS. Investigasi awal penelitian material longsoran ini yaitu uji sifat fisik tanah pada lokasi kelongsoran tebing jalan raya nasional Trenggalek-Ponorogo Km 15 dan Km 17. Hasil analisis saringan menunjukan Km 15 memiliki gradasi baik dan Km 17 memiliki gradasi butiran buruk. Uji specific gravityÂ kedua sampel menunjukan bahwa nilaiÂ GSÂ = 2,6 â€“ 2,7 yaitu material berupa pasir berlanau dengan plastisitas rendah. Klasifikasi metode AASHTO diketahui sampel Km 15 dan Km 17 merupakan tanah dengan kode A-2-4, dan dari klasifikasi metode USCS sampel tanah memiliki kode SW dan SP. Pengujian slake durability dilakukan pada material batuan km 15 dan km 17 yang menghasilkan Km 15 memiliki durabilitas tinggi dengan Id2Â = 83,7% dan Km 17 durabilitas rendah dengan Id2Â = 33,2%. Uji X-RD dilakukan pada Km 15 dengan didominasi mineral Laumontite sebesar 32% dan hasil X-RF memiliki kandungan tertinggi Silika Oksida (SiO2) sebesar 42,2%. Uji X-RD pada Km 17 menampilkan hasil kandungan tertinggi yaitu Albite sebesar 46% dan uji X-RF menunjukan senyawa Silika Oksida (SiO2) mendominasi dengan nilai 41,2%. SEM-EDX didapati material Km 15 dan Km 17 mengandung unsur O, C, Si sebagai unsur tertinggi sebagai pembentuk utama sampel tanah.
Analisis Banjir Sungai Remu Kota Sorong Papua Barat Menggunakan Aplikasi Zhong Xing HY21 Analysis of the Remu River Flood Sorong City West Papua Using the Zhong Xing HY21 Application
Authors: Siregar Muhammad Rafi , Asmaranto Runi , Juwono Pitojo Tri
Published: January 2023

Curah hujan yang tinggi menyebabkan terjadinya luapan di Sungai Remu merupakan salah satu penyebab terjadinya banjir di Kota Sorong. Terjadinya banjir di sekitar Sungai Remu disebabkan banyak faktor juga, salah satunya perubahan tata guna lahan di bagian hulu yang mengalami perubahan menjadi lahan pertanian, dan juga kegagalan penampang yang ada tidak bisa menampung air yang menyebabkan banjir. Maka dengan adanya hal tersebut perlu dilakukan analisis rambatan banjir Sungai Remu menggunakan aplikasi Zhong Xing HY21. Analisis ini membutuhkan perhitungan hidrologi dan statistika untuk memperoleh debit banjir rencana. Penggunaan metodenya dengan Hidrologi Satuan Sintesis Nakayasu dengan Q25 th. Setelah mendapatkan debit banjir rancangan, kemudian dilakukan analisis rambatan banjir menggunakan aplikasi Zhong Xing HY21. Berdasarkan hasil analisis tersebut, didapatkan seluruh desa tergenang banjir dengan total luasan banjir 2.183 km2. Sehingga dibuatnya Rencana Tindak Darurat sangat penting dengan membuat kelas prioritas dengan urutan evakuasi yaitu, Remu Selatan, Remu Utara, Malamso, Remu, Malawei, Malabutor, dan Malaingkedi.
Studi Optimasi Pemanfaatan Air Irigasi Menggunakan Program Linier Pada Daerah Irigasi Manikin Kabupaten Kupang
Authors: Kharistanto Robertus Tegar Kurnia , Limantara Lily Montarcih , Soetopo Widandi
Published: January 2023

Daerah Irigasi Manikin mengairi sawah seluas 201,87 hektar, terletak di NTT yang dikenal dengan musim kemarau panjang, hal tersebut secara langsung berpengaruh pada ketersediaan air untuk irigasinya. Agar ketersediaan air saat musim kemarau tercukupi dan dapat mengairi sawah, dilakukan optimasi pada luas areal tanaman yang akan diairi menggunakan ketersediaan air yang ada dengan metode program linier supaya mendapatkan luasan tanam yang optimal dan keuntungan yang didapat juga lebih optimal. Studi ini dilakukan dengan pengoptimalan pola tanaman di lapangan dan penambahan tiga pola tanam alternatif sebagai pilihan pada debit andalan 80% (kering), 50% (normal), dan 30% (basah). Setelah dioptimasi pada semua debit andalan, rerata neraca air yang hanya dapat tepenuhi 80% periode tercukupi dapat di maksimalkan ke 100% periode tercukupi, dengan rincian untuk eksisting memiliki intensitas tanam 200%, dan keuntungan Rp.4.643.010.000, alternatif 1 memiliki intensitas tanam 269,78%, dan keuntungan Rp.6.234.664.440, alternatif 2 memiliki intensitas tanam 300%, dan keuntungan Rp.6.915.540.000, alternatif 3 memiliki intensitas tanam 269,78%, dan keuntungan Rp.5.854.139.490. Pola tanam alternatif 2 dengan tanaman padi- padi/kacang tanah-padi dipilih sebagai yang terbaik untuk dilaksanakan karena memiliki intensitas tanam yang optimal 300% dan keuntungan sebesar Rp.6.915.540.000 per tahun lebih besar Rp. 2.272.530.000 dari keuntungan pola tanam eksisting yang hanya Rp.4.643.010.000 per tahun.
Methodologically and Psychological Aspects in the Gymnastics Training
Authors: Radoev Sergey
Published: January 2023

The author has created two gymnastic exercises on parallel bars on the basis of objective logical analysis. One of them (bent with side straddleturn and twist on 90 degrees to longitudinal angle swing) is performed by the author and some other gymnastics. The next one—the same with open legs is performed only by the author (1989), which makes the article innovative activity. By this moment no other gymnast has performed the exercise.The significance of the physical and the technical as well as the psychological preparation for successful learning of new and difficult gymnastic exercises is underlined.
The Search for Truth: A Psychological Analysis of Bulgarian Children’s Adaptation to the Portuguese Language Environment with a Special Focus on Translanguaging
Authors: Matelova Bojana
Published: January 2023

There is an increasing migration from Bulgaria to Brazil. The group of migrants is very homogenous since they arrive with the same aim of working and saving money for a better future at home in Bulgaria. The statistics reveal that the migrants often arrive with families, including children, who must attend compulsory schools in Brazil. According to Brazilian law, all children are entitled to education in the Portuguese language. This creates many problems for newly arrived families who have limited knowledge of Portuguese. This paper investigates Bulgarian children’s meta-language and translanguaging approaches during official schooling and extracurricular activities. The theoretical framework is grounded in the theories about translanguaging and second language development of newly arrived children. The participants of the study are 55 Bulgarian children who were observed in various environments: at schools, at home and during extracurricular activities with peers. The main findings paint an interesting pattern of the various ways to convey the meaning through translanguaging depending on the contextual situation.
Eficacia de sofosbuvir/ledipasvir en comparación con la combinación sofosbuvir, peginterferón y ribavirina sobre la respuesta viral sostenida en adultos con hepatitis C. Revisión sistemática y meta-análisis
Authors: Ramírez-Peniche María Fernanda , Sánchez-Rodríguez Martha A.
Published: January 2023

Antecedentes. El algunos estudios se ha reportado que el tratamiento con sofosbuvir/ledipasvir (SOF/LDV) para la hepatitis “C” tiene una respuesta viral sostenida (RVS) superior que la combinación de peginterferón (PEG) y riba­virina (RBV), sin embargo los estudios son escasos e in­consistentes, de ahí la relevancia de llevar a cabo un revi­sión sistemática y meta-análisis. Objetivo. Presentar una síntesis del conocimiento sobre la eficacia de sofosbuvir/ ledipasvir en comparación con la combinación sofosbuvir, peginterferón y ribavirina sobre la respuesta viral sosteni­da en adultos con hepatitis C, a través de una revisión sistemática y meta-análisis. Método. Se llevó a cabo una búsqueda de estudios en las bases de datos “PubMed”, “Scopus”, “Web of Science”, “LILACS” y “SciELO”, acorde con los lineamientos de PRISMA; utilizando una estrategia PICO aplicada a ensayos clínicos. Se analizaron los estu­dios seleccionados hasta el 21 de octubre de 2021. Se llevó a cabo una evaluación de riesgo de sesgo y se realizó un meta-análisis con el software RevMan V5.4. Resultados. Un total de 818 artículos fueron identificados y 8 estudios cumplieron con los criterios de elegibilidad, para la revisión sistemática y 7 para el meta-análisis. En el análisis cuan­titativo no se encontró diferencia entre la administración de la combinación Sofosbuvir/Ledipasvir con la administra­ción de la intervención más ribavirina, interferón pegilado o ambos, diferencia de medias= 0.03 (IC95%: -0.03 a 0.09), con RVS mayor al 94%. Conclusión. Nuestros hallazgos sugieren que la combinación Sofosbuvir/Ledipasvir tiene una eficacia similar si se agrega ribavirina para el trata­miento del VHC genotipo 1, pues ambos regímenes dan RVS semejantes.
Eficacia de sildenafil en comparación con tadalafil, para el mejoramiento de la vida sexual en hombres adultos con disfunción eréctil: revisión sistemática y meta-análisis
Authors: González-Meneses Baruch Admín , Sánchez-Nieto José Miguel
Published: January 2023

Antecedentes. La disfunción eréctil es una condición fre­cuente, su prevalencia aumenta con la edad y otras comorbi­lidades. Entre los tratamientos más utilizados se encuentran el sildenafil y el tadalafil. En los estudios que comparan la eficacia de estos medicamentos se han reportado resultados inconsistentes. Objetivo. Presentar una síntesis del cono­cimiento sobre la eficacia de sildenafil en comparación con tadalafil como tratamiento de la disfunción eréctil en adul­tos, a través de una revisión sistemática. Método. Se llevó a cabo una búsqueda de estudios en PubMed, Scopus, Web of Science, LILACS, SciELO y TESIUNAM de acuerdo con los lineamientos PRISMA. Se analizaron los estudios selecciona­dos hasta el 13 de diciembre de 2021. Resultados. Un total de 607 artículos fueron identificados y 9 artículos cumplieron los criterios de elegibilidad para la revisión sistemática. Respec­to al mejoramiento de la función eréctil, medido con el cues­tionario IIEF-EF, no se reportan diferencias estadísticamente significativas entre sildenafil y tadalafil (Diferencia de Medias= 0.20, IC-0.42, 0.81, p>0.05). Con relación a la preferencia por el tratamiento, determinada por la elección del sujeto después de haber recibido ambos tratamientos, se encontró una pre­ferencia estadísticamente significativa por tadalafil (OR=15.8, IC 11.33, 22.14, p<0.05). Se observó un riesgo de sesgo alto en los estudios seleccionados es alto Conclusión. Los resul­tados sugieren que la eficacia, medida por el mejoramiento de la función eréctil, no es diferente entre sildenafil y tadalafil. La mayoría de los sujetos prefieren continuar tomando tadalafil al haber recibido ambos medicamentos. Sin embargo, es nece­sario realizar más ensayos clínicos aleatorizados, debido a la baja calidad de los estudios disponibles.
Odontología de Mínima Intervención para la atención de Caries Dental en un Modelo de Servicio Estomatológico
Authors: Hernández-Monjaraz Beatriz
Published: January 2023

El libro “Odontología de Mínima Interven¬ción para la atención de Caries Dental en un Modelo de Servicio Estomatológico”, es un texto académico, didáctico, dirigido a los estudiantes de la carrera de Cirujano Dentista, de acceso libre (https://www.za¬ragoza.unam.mx/area-quimico-biologicas/).
La producción del espacio habitacional de la Alcaldía Azcapotzalco, Ciudad de México: un recorrido cartográfico
Authors: García Reyes Juan Manuel
Published: January 2023

La animación cartográfica, con elementos computacionales provenientes de la visualización científica de datos, aumenta el potencial analítico de los mapas. La serie dinámica espacio-temporal es una animación a través del tiempo. La narrativa cartográfica es un recorrido guiado a través de un mapa con el despliegue paulatino de una historia correspondiendo a los procesos sucedidos en cada etapa del recorrido. A través de una narrativa cartográfica es posible dar cuenta de la espacialidad de las relaciones sociales y sus implicaciones, cosa difícil con el layout tradicional del mapa. En este trabajo mostramos cómo se creó un mapa interactivo, una serie dinámica espacio-temporal y una narrativa cartográfica (accesible a través del portal de la revista) con tecnologías de software libre (incluyendo Geoserver y OpenLayers), para examinar las implicaciones socio-espaciales de procesos en el espacio urbano de la Alcaldía Azcapotzalco desde los inicios de su urbanización hasta los inicios del siglo XXI (2008). Articulamos la visualización cartográfica con una investigación sobre la producción del espacio urbano desde la perspectiva de que el espacio es producto y productor de lo social; esto quiere decir que la sociedad realiza su propio espacio, al tiempo que él mismo determina la constitución de las relaciones sociales. Nuestra narrativa demuestra que la composición social diversificada de Azcapotzalco se ve reflejada en su espacio habitacional, constituido en la demarcación por décadas, y el arraigo y extracción popular han hecho que persista una resistencia frente a la ola de gentrificación procedente de las zonas más céntricas de la ciudad.
Modelado espacial del potencial de energía solar en México a partir de Modelo Digital de Elevaciones ASTGTM V3
Authors: Hernández Martínez Diana , Ferrari Luca
Published: January 2023

Presentamos un modelo de alta resolución de la irradiación total del territorio nacional obtenido por medio del módulo "Solar Radiation toolset" de ArcGIS aplicado a un modelo digital de elevación (MDE) de alta resolución (30 x 30 m) obtenido a partir del Modelo de Elevación Digital Global, Versión 3, del Radiómetro de Reflexión y Emisión Térmica Espacial Avanzado de Terra (ASTGTM V3), cuyos datos se procesaron para eliminar valores erróneos. La alta resolución del MDE mejora significativamente los resultados particularmente en las zonas de cambios de relieve abrupto, que tienden a homogenizarse en modelos de baja resolución. Por cada celda se obtuvo la Radiación Solar Directa y la Radiación Solar Difusa con la finalidad de obtener la Radiación Solar Global en kilovatios hora por metro cuadrado (kWh/m$^2$). El resultado se presenta en 12 mapas mensuales y uno anual de la Radiación Solar Global del territorio nacional. Los meses que presentan mayor potencial de radiación solar corresponden a los meses de primavera y verano, con un máximo absoluto para el mes de julio. Los resultados teóricos de este trabajo se compararon con los valores de radiación de los modelos publicados por el National Renewable Energy Laboratory (NREL), y el Banco Mundial. Estos últimos muestran una sobreestimación del potencial solar debido a su menor resolución, particularmente en zonas con topografía abrupta.