bluuebunny/crossref_metadata_2025 huggingface dataset:
A Rare But Significant Cause of Recurrent Pseudomonas Tonsilitis: Common Variable Immunodeficiency
Authors: AYTEKİN Gökhan , ÇÖLKESEN Fatih , YILDIZ Eray , ARSLAN Sevket
Published: September 2020

Upper respiratory tract infections (URTI) one of the most common clinical situations encountered by primary care physicians and internal medicine specialists. Viruses are the most common etiologic cause and the clinical picture is usually self-limiting. However, the symptoms of viral URI are substantially similar to those of major pharyngitis agents such as group A Streptococcus (GAS). When atypical presentations and atypic bacterial infections are suspected, microscopic examination of the throat culture is a frequently used laboratory test. Atypical microorganisms detected as a result of throat culture are evaluated as laboratory error and / or contamination and apossible underlying immunodeficiency conditions are overlooked. The diagnosis of the patients is delayed due to the perception of immune deficiency as childhood diseases and the lack of awareness in this regard. In this case, we aimed to present a patient with recurrent tonsillopharyngitis complaints whose first throat culture results was possitive for a gram (-) microorganism and second throat culture was positive for pseudomanas aerigunosa. As a result of further investigations of the patient's lung, bronchiectasis sequelae and diminished count of switched memory B cells were detected. The patient was diagnosed with common variable immunodeficiency, and her complaints disappeared completely with 400 mg / kg intravenous immunoglobulin replacement. In conclusion, it is very important to evaluate the patients especially in the presence of stimulant signs in terms of immunodeficiency, or to refer them to the Immunology department, to manage the complications.
Proton Pompa İnhibitörlerinin Uzun Dönem Kullanımındaki Etkileri
Authors: İSPİROĞLU Murat , GİŞİ Kadir , KANTARÇEKEN Bülent
Published: September 2020

Proton pompa inhibitörleri (PPI) iyi bir güvenlik profiline sahip ve toplumda çok sık kullanılan ajanlardır. Sık kullanılan bu ilaçların yan etkisi konusunda net veriler olmamakla birlikte, bu yan etkilerin daha çok uzun süre kullanımı sonucu baskılanan mide asidine bağlı olduğu düşünülmektedir. Biz burada daha çok zeminde oluşan uzamış hipoklorhidri ve hipergastrineminin neoplastik sonuçları, malabsorbsiyon, enfeksiyonlar ve diğer nedenler ana başlıkları altında konuyu tartışmaya çalıştık.
EPIDERMOID CYST OF THE PALATINE TONSIL: AN INCIDENTAL RARE FINDING AND LITERATURE REVIEW
Authors: UĞUR KILINÇ Ayşe Nur
Published: September 2020

Epidermoid cysts are developmental lesions and may be seen in the head and neck area with an incidence rate of 2% as well as in different organs of the body. Epidermoid cysts are located in sublingual, submental, submandibular and buccal mucosa and rarely at tonsils in the head and neck area. They congenitally occur in fetal period or occur as an acquired lesion due to a trauma or implant after surgery.

In this case report, we will discuss the epidermoid cyst, a rare incidental finding developing at tonsils, in a 6-year-old boy with chronic tonsillitis with literature review.

In conclusion, tonsil hyperplasia may also be caused by cystic developments at the tonsils. It should clinically be kept in mind especially in differential diagnosis of malignancy in the asymmetry of tonsils. Tonsillectomy materials commonly used in routine medical practice should be histopathologically and carefully examined and other accompanying pathologies of chronic tonsillitis should also be considered
VERBALIZATION OF THE NATIVE LAND CONCEPT IN OLEKSII DOVHIY'S POETRY
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Strokal Oleksandr
Published: September 2020

The article deals with the peculiarities of the linguistic expression of the NATIVE LAND concept in Oleksii Dovhiy's poetry. The study found that the current stage of linguistics is characterized by an understanding of the concept as a general concept and complex of culturally determined perceptions of the subject. The concept itself is a designated element of the ideal that represents the reality of the speaker through the prism of his culture. The article argues that the individual's ideas about the subject are realized in the artistic text through a figurative system. The image is considered as the main means of artistic generalization of reality, as a sign of the objective correlate of human experiences and as a special form of social consciousness. In Oleksii Dovhiy's poetic texts the image of the native land is one of the most vividly presented. For the poet's lyrical hero, this image serves as a special place, a sacred locus, the beginning of all things. This vision of the lyrical hero is expressed in the nominations for the designation of landscape elements, natural phenomena and their characteristics. Supplements the analyzed locus introduced by the author image of the Big Father, expressed by the respective linguistic units. The author's poetic language presents linguistic constructions that explicate the image of the native land as the beginning of all things a place in which the memory of the heroic past and the difficult tests are stored at the same time.
Congestion in Computational Evacuation Modelling
Authors: Schneider Volker , Könnecke Rainer
Published: September 2020

The time-based analysis of egress scenarios is a long-standing and well-established method to evaluate occupant safety. It is based on the necessary condition that the required egress time is smaller than the available egress time. The former is derived by the application of evacuation models, the latter by calculation of smoke and heat spread in the case of a fire incident. In the calculation of required egress time the time-dependent development of occupant density and consequently the emergence of congestion often play a crucial role. There is a demand to evaluate the development of local occupant density and jam situations independent of the above time-based criterion. This is for example reflected in national guidelines and standards. It is however difficult to obtain general valid evaluation criteria for congestion due to the multitude of influencing parameter and the highly situation-dependent nature of the accompanying boundary conditions. In addition, prediction of localization and duration of congestion may differ from model to model if applied to equal scenarios. Furthermore, close inspection reveals the difficulty to define proper terms for a quantitative definition of congestion. This issue is further analysed in this paper based on three case studies.
Decentralized Control for Self-driving Cars That can Freely Move on Two-dimensional Plane
Authors: Kano Takeshi , Iwamoto Mayuko , Ueyama Daishin
Published: September 2020

In the current traffic rules, cars have to move along lanes and to stop at red traffic lights. However, in the future when all cars become completely driverless, these traffic rules may vanish and cars may be allowed to move freely on two-dimensional plane by avoiding others like pedestrian flow. This innovation could greatly reduce traffic jams. In this study, we propose a decentralized control scheme for future self-driving cars that can freely move on two-dimensional plane, based on the social force model widely used as the model of pedestrian flow. The performance of the proposed scheme is validated via simulation. Although this study is still conceptual and does not consider realistic details, we believe that it paves the way to developing novel traffic systems.
Empirical Findings from an Ascending Stair Evacuation Exercise in a Subway Station
Authors: Schrom-Feiertag Helmut , Matyus Thomas , Stubenschrott Martin , Seer Stefan
Published: September 2020

Crowd simulations have proven to be a valuable numerical tool for evacuation analysis. There is series of research and empirical evacuation studies for infrastructures and buildings. In contrast to research on evacuation via descending stairs, little attention has been given to ascending stairs, but they are an important criterion, especially in subway stations with high passenger frequencies. In this paper, we present the findings from an evacuation exercise in a subway station with long ascending stairs. The empirical findings showed an increasing walking time on the ascending stairs during evacuation. Also, the flow rate differs with higher flow rates at the beginning of the stairs and lower values at the end of the stairs. The mechanism behind these results has still to be investigated, but the findings already provide an interesting basis for modelling and validating evacuation simulations over long ascending stairs.
A Case for Identity Hierarchies in Simulating Social Groups
Authors: Platt A. , Kneidl A.
Published: September 2020

By considering previous empirical studies in group dynamics, modelling designs for pedestrian simulators and psychological and sociological theories of crowd behaviour, we briefly present a hierarchical, identity-based approach to simulating pedestrian social groups.
A reinvindicação da memória em Formas de volver a casa, de Alejandro Zambra ou como construir “La Novela de los hijos” / The Claim of Memory in Ways to Return Home, by Alejandro Zambra or How to Build “La Novela de los hijos”
Authors: Costa Júlia Morena , Machado Priscila
Published: September 2020

Resumo: Este artigo objetiva refletir sobre o lugar ocupado pela memória na construção da narrativa de Formas de volver a casa (2011), de Alejandro Zambra, tanto na sua dimensão estética como política. A partir dessa elaboração, discute-se sobre a legitimidade do uso da memória e da construção do passado por uma geração que opera no presente, com distanciamento temporal dos eventos históricos que marcaram as últimas décadas no Chile e na América Latina, em especial da ditadura militar de Augusto Pinochet e do processo de (re)democratização do país. Na defesa de uma narrativa própria, tanto na história como na literatura, propõe-se partir de análises de elementos como a casa, a cidade e a narrativa, para estabelecer relações sobre a construção de uma memória geracional sobre os eventos políticos dos séculos XX e XXI chilenos, assim como seus impactos nas discussões públicas e coletivas, como nos âmbitos pessoais e familiares. Para isso, são usadas reflexões propostas por autores como Georges Didi-Huberman, Paul Ricoeur, Walter Benjamin e Raúl Antelo.Palavras-chave: memória; Alejandro Zambra; memória geracional; literatura latino-americana contemporânea; história.Abstract: This article aims to reflect on the place occupied by memory in the construction of the narrative of Formas de volver a casa (2011), by Alejandro Zambra, both in its aesthetic and political dimensions. Based on this elaboration, the legitimacy of the use of memory and the construction of the past is discussed by a generation that operates in the present, with temporal distance from the historical events that marked the last decades in Chile and Latin America, especially the dictatorship Pinochet’s military and the process of (re) democratization. In defense of its own narrative, both in history and in literature, analyzes of elements such as the house, the city and the narrative, are proposed as a starting point to establish relationships on the construction of a generational memory on the political events of the Chilean’s 20th and 21th centuries, as well as their impacts on public and collective discussions, and on personal and family spheres. For this, reflections proposed by authors such as Georges Didi-Huberman, Paul Ricoeur, Walter Benjamin and Raúl Antelo are usedKeywords: memory; Alejandro Zambra; generational; contemporary Latin American literature, history.
O sujeito pronominal na fala de Natal/RN: retrato de uma mudança em tempo aparente / The Pronominal Subject in Natal/RN: Portraits of a Change in Apparent Time
Authors: Martins Marco Antonio Rocha , Carvalho Júnior Sammy Vieira
Published: September 2020

Resumo: Seguindo os pressupostos da Teoria da Variação e Mudança linguística, apresentamos neste artigo uma análise de regra variável da expressão do sujeito pronominal em sentenças matrizes na fala de Natal/Rio Grande do Norte/Brasil, com o objetivo de mapear a evolução do preenchimento do sujeito nessa comunidade. Nossa hipótese é de que a fala de Natal evidencia um quadro de mudança gramatical que pode ser observada sob as lentes da mudança em tempo aparente, conforme postulados de Labov (1994). A amostra analisada compõe-se de oito entrevistas realizadas na década de 2010, extraídas do corpus FALA-Natal, com informantes socialmente estratificados. Considerando quatro faixas etárias diferentes dos informantes (Faixa 1 de 8 a 12 anos; Faixa 2 de 15 a 21 anos; Faixa 3 de 25 a 45 anos; e Faixa 4 mais de 50 anos), os resultados mostram que a representação do sujeito pronominal reflete um caso de mudança em tempo aparente, uma vez que construções com sujeitos preenchidos são condicionadas por informantes mais novos, da faixa etária 1, em oposição aos demais informantes das faixas subsequentes.Palavras-chave: preenchimento do sujeito; mudança em tempo aparente; português brasileiro; FALA-Natal.Abstract: In the Theory of Variation and Linguistic Change, we present an analysis of the variable rule of the expression of the pronominal subject in matrix sentences in the speech of Natal/Rio Grande do Norte/Brazil, with the aim of mapping the evolution of the subject’s filling in this community. Our hypothesis is that the speech of Natal shows a grammatical change, which can be observed in light of change in apparent time, as postulated by Labov (1994). The sample analyzed was taken from eight interviews conducted in the decade of 2010, extracted from the FALA-Natal corpus, with socially stratified informants. Considering four different age groups of informants (Group 1 from 8 to 12 years; Group 2 from 15 to 21 years; Group 3 from 25 to 45 years; and Group 4 over 50 years), the results show that the representation of the pronominal subject reflects a case of change in apparent time, since constructions with filled subjects are conditioned by younger informants, in age group 1, as opposed to the other informants in the subsequent groups.Keywords: subject completion; change in apparent time; Brazilian Portuguese; FALA-Natal.
Kolorektal premalign polipler ile mide premalign lezyonları arasındaki ilişki
Authors: ERDAL Harun , GÜNAL Armağan , ÇELİK Bülent , SAKİN Yusuf , ERÇİN Cemal , UYGUN Ahmet , GÜLŞEN Mustafa
Published: September 2020

Giriş ve Amaç: Kolorektal premalign lezyonların en önemlisi poliplerdir. Poliplerin histopatolojisi ve boyutlarına göre malignite riski değişmektedir. Ayrıca mide mukozasında displazi, atrofi, intestinal metaplazi, polip ve Helicobacter pylori gibi faktörler de mide için prekanseröz durumlardır. Çalışmamızın amacı; kolorektal poliplerin yerleşimi, boyutu, sayısı ve patolojisi ile midenin premalign lezyonları arasındaki ilişkiyi ortaya koymaktır. Gereç ve Yöntem: Çalışmamız Ekim 2016 ile Ekim 2019 tarihleri arasında 18 yaş ve üzeri hastalara aynı gün yapılan özofagogastroduodenoskopi ve kolonoskopi verilerinin değerlendirildiği retrospektif bir çalışmadır. İnflamatuvar barsak hastalığı olan, mide kanseri ve kolorektal kanser tanısı alan, mide biyopsisi alınmayan, barsak temizliği yetersiz olan ve işlemi tamamlayamayan hastalar çalışmaya dahil edilmemiştir. Bulgular: İki yüz elli yedi hastanın %58.0’i erkek ve %80.9’u 50 yaşın üzerindeydi. Kolorektal poliplerin çoğunluğu distal yerleşimliydi (%59.1). İleri adenomatöz polip (İAP) sıklığı %24.9 olup ileri adenomatöz polip varlığı ile 50 yaş altı ve üzeri hastalar arasında ve cinsiyete göre istatistiksel fark yoktu (p: 0.659 ve p: 0.747). Helicobacter pylori, atrofi, intestinal metaplazi, displazi ve polip gibi midenin premalign lezyonları ile ileri adenomatöz polip arasında istatistiksel olarak anlamlı bir ilişki gözlenmedi (p: 0.301 ). Sonuç: Kolorektal poliplerin yeri, sayısı ve ileri adenomatöz polip ile premalign mide lezyonları arasında ilişki saptanmamıştır.
Una revisión sobre las tierras abandonadas en España: de los paisajes locales a las estrategias globales de gestión
Authors: Lasanta T. , Nadal-Romero E. , Khorchani M. , Romero-Díaz A.
Published: September 2020

Las tierras abandonadas ocupan espacios muy extensos en algunos territorios españoles, especialmente en las áreas de montaña y ambientes semiáridos. Originan paisajes muy diversos en función de las condiciones climáticas, el lugar y la edad de abandono, la gestión previa y posterior, y las perturbaciones que sufren durante el proceso post-abandono. Estos factores condicionan la sucesión vegetal y las propiedades edáficas, dando lugar a ecosistemas y paisajes tan contrastados como bosques, matorrales, pastizales y suelos casi desnudos. En este trabajo se revisan los conocimientos actuales sobre el abandono de tierras en España a partir de la bibliografía, con especial referencia al proceso espacio–temporal del abandono, los factores que originan diferentes ecosistemas y paisajes en las tierras abandonadas y las implicaciones de éstos en el suministro de servicios ecosistémicos a la sociedad. En función del paisaje generado y de su gestión dependen la cantidad y calidad de los recursos hídricos, la protección del suelo, el secuestro y stock de carbono, los niveles de biodiversidad, la prevención y control de incendios forestales, los recursos pastorales, la estética del paisaje e incluso las posibilidades de fijar población en el medio rural a partir de aprovechamientos extensivos.
Prevalence of teenage pregnancy and its obstetric and perinatal outcomes in a rural tertiary care hospital
Authors: Krishna Madala Venkata Ramya , Gangadharan Keshav , Shivaraju Pradeep , Mateti Devivaraprasad
Published: September 2020

Background: Teenage pregnancy has been reported as one of the leading causes of death in adolescent girls in both developed and developing countries. In developed countries teenage pregnancies are most common in unmarried girls whereas in developing countries like India where early marriages are more common, teenage pregnancies are seen mostly in married women.Methods: In this retrospective observational study, data between January 2018 and December 2019 was studied; data was evaluated using MS excel for statistical purpose. In the present study, only pregnant women less than 20 years were included.Results: Out of 6,028 pregnant women delivered during this period, 686 i.e. 11.3% age of women were less than 20 years, 609 (88.7%) had delivery at term and the remaining 77 (11.2%) women had preterm delivery. As per this study, incidence of hypertensive disorders were 12.24%, 5.5% were associated with anemia and most of them had vaginal delivery (65.01%) including induced and instrumental; cesarean section was 35.5%. In present study, 24.1% babies were of low birth weight and 3.49% of babies were intrauterine growth restricted (IUGR) babies.Conclusions: This study showed hypertensive disorders were the most common maternal complication and the incidence of vaginal delivery was higher compared to that of cesarean section, incidence of anaemia was less compared with other studies. Proper antenatal care, institutional delivery and postnatal care can reduce fetal and maternal complications in childbearing women in teenage age group.
Uterine artery Doppler in first trimester in prediction of adverse pregnancy outcome in Dharmapuri district of Tamil Nadu
Authors: S. Bindu
Published: September 2020

Background: Pregnancies are complicated by hypertensive disorders of about 5-10% and hemorrhage, sepsis, and fetal growth restriction constitute a triad contributing to maternal morbidity and mortality. Hypertensive disorders in pregnancy vary from mildly elevated blood pressure to severe hypertension with multi-organ dysfunction. The study aims to evaluate the first-trimester uterine artery Doppler in the prediction of the development of adverse pregnancy outcomes.Methods: This prospective longitudinal observational was done in Dharmapuri Medical College and Hospital were selected for this study. Totally 150 pregnant women were included in the study. 75 were controls and 75 cases. The study period was from June 2018 to February 2019. Evaluating the optimal definition of abnormal first trimester.Results: Previous obstetric history in the study population. In the study group 3% of bad obstetric history (BOH) present. In the case group, 5% has BOH due to 2 neonatal death and 2 term intrauterine device (IUD), uterine artery Doppler parameters to predict adverse pregnancy outcomes, and association of gestational hypertension in the study groups. In the control group, 1%, and the case group 5% of them had gestational hypertension. Out of 4, 3 had an average uterine artery Doppler more than 2.3 (maximum of 2.7) and 1 had single uterine artery Doppler abnormality.Conclusions: The study showed that first-trimester uterine artery Doppler with single and average uterine artery pulsatility index (PI) >95th centile (2.3) has a better screening value in my population. The overall performance of the first-trimester uterine artery Doppler in the prediction of adverse pregnancy outcomes is valuable.
Agency and Adaptation: Strategies of Immigrants’ Descendants on the Swedish Labor Market
Authors: Aslan Pinar , Ahmadi Nader , Wikström Eva , Sjöberg Stefan
Published: September 2020

This article explores how descendants of immigrants in Sweden understand labor market conditions, and how such understandings influence their occupational strategies. We interviewed 21 Sweden-born individuals with non-Western immigrant parents, and identified three strategies based on our analysis of the data: ‘choosing’ the right job, adapting the habitus, and using cultural capital in flexible ways. The first strategy covers interviewees working in jobs with labor shortages and/or high demand for employees with immigrant background. The second covers interviewees who could learn through failing, with substantial resilience and persistence. The third deals with interviewees who searched for jobs in branches that valued their particular skill set, entailing the importance of being flexible on the labor market
Peso e capacidade de armazenamento da vesícula melífera de abelhas africanizadas no Sul de Santa Catarina
Authors: Silva Lucas Almeida da , Anastácio Maurício Duarte , Souza Tuan Henrique Smielevski de , Spido Diou Roger Ramos , Semprebon Diogo Policarpo , Arboitte Miguelangelo Ziegler
Published: September 2020

Objetivou-se avaliar o peso das abelhas operárias e a capacidade da vesícula melífera de Apis mellifera L. africanizadas na região Sul de Santa Catarina. As abelhas foram acondicionadas em potes para a mensuração de seus pesos e, posteriormente, fornecido mel até apresentarem saciedade e pesadas para a quantificação da capacidade da vesícula melífera. O peso médio das abelhas africanizadas vazias foi de 76,20±10,33 mg. A capacidade média da vesícula melífera foi de 24,50±12,69 mg. O baixo coeficiente de determinação da equação de regressão (r2 = 0,03998) demonstra a variabilidade existente entre o peso e a vesícula melífera das abelhas africanizadas. O peso e a capacidade da vesícula melífera das abelhas na região sul de Santa Catarina verificados foram de 76,20 mg e 24,50mg, respectivamente.
Estratégia de Controle para Conversor Boost Fotovoltaico Operando nos Modos MPPT e LPPT
Authors: Dos Santos Cássia C. C. , Da Costa Jean P. , Stein Carlos M. O. , Carati Emerson G. , Cardoso Rafael , Nadal Zeno L. I.
Published: September 2020

Este artigo propõe uma estratégia de controle composta por um algoritmo de rastreamento do ponto de máxima potência (MPPT) e um algoritmo de rastreamento do ponto de potência limitado (LPPT) para conversores boost aplicados a um sistema fotovoltaico. Primeiramente, uma técnica MPPT tradicional é implementada e a partir disso, a técnica de LPPT proposta nesse trabalho é desenvolvida sem adição de novos sensores. O LPPT desenvolvido pode ser empregado tanto em sistemas fotovoltaicos que possuem apenas um conversor boost no estágio CC como também em sistemas com múltiplos conversores compartilhando o mesmo barramento CC do lado do inversor. Além disso, a estratégia proposta pode contribuir com o controle do inversor fotovoltaico quando o sistema necessita limitar a potência ativa gerada. É demonstrado que uma rápida resposta dinâmica de transição entre os modos de operação pode ser obtida com a estrutura proposta. Resultados experimentais em um arranjo de 3 kW são apresentados para dar suporte a teoria desenvolvida e ilustrar o bom desempenho do sistema.
Yara kültürleri sonuçlarının Q skorlaması ile birlikte analizi
Authors: BAYIRLI TURAN Derya
Published: September 2020

Amaç: Yara kültürleri sonuçlarının yara örneği kalitesi ile birlikte değerlendirilmesi klinisyene etkenin saptanması konusunda önemli bilgi sağlamaktadır. Yara örneğinin kalitesi Q skorlaması ile yapılabilmektedir. Üçüncü basamak hastanemizde takip edilen hastalara ait yara örneklerinin kültür sonuçlarının, örneklerin mikroskobik incelemesiyle saptanan Q skorlaması kullanılarak analiz edilmesi amaçlanmıştır.Gereç ve Yöntemler: Çalışmaya yara enfeksiyonu ön tanısıyla başvuran ya da yatarak takip edilen toplam 311 hastadan alınan yara kültürü örneği dahil edildi. Yara kültüründe üreyen mikroorganizmalar tam otomatize VITEK II Compact (Biomeriux, Fransa) sistemle identifiye edildi. Ayrıca örneklerin düşük büyütme X10 ile yapılan mikroskobik incelemesinde her alanda görülen polimorfnüveli lökosit (nötrofil) ve epitel hücre sayıları kaydedildi ve bu sayılara göre her bir örnek için Q skorları belirlendi. Gruplar arasındaki farklılıklar ki kare testi ile analiz edildi.Bulgular: Yara kültürlerinin 226’sı (%72.7) Q1 veya üzeri Q skoruna sahipti. Üreme görülmeyen kültürlerin %20'si, üreme olanların ise %80’i Q2 veya üzeri Q skoruna sahipti. Bir veya daha fazla patojen etkenin görüldüğü örneklerin %85.2’si Q1 veya üzeri Q skoruna sahipken, cilt florası bakterilerinin %71.3’ü Q1 veya üzeri Q skoruna sahipti, bu oranlar arasındaki fark istatistiksel olarak anlamlı idi (p=0.0154). Cilt florası dışındaki patojen etkenler içinde en sık üreyen mikroorganizmalar metisiline duyarlı Staphylococcus aureus (%21.7), metisiline dirençli S.aureus (%13.3) idi.Sonuç: Çalışmamızda özellikle Q0 skorlu örneklerin reddedilmesi gerektiği, bu örneklerin çalışılması halinde maliyete ve hasta için zaman kaybına yol açabileceği ve klinisyeni tanı ve tedavi açısından yanlış yönlendirebileceği görülmüştür. Verilerimizin araştırmacılara ve klinisyenlere katkı sağlayacağı, yara kültürlerinin işlenme ve değerlendirmesi bakımından bir kılavuz oluşturulması gerektiği düşüncesindeyiz.
Application of Blending Teaching in College English Classroom
Authors: Fang Fang
Published: September 2020

With the organic integration of online and offline teaching, the blending teaching not only expands the teaching time and space, but also ensures a sufficient amount of language communication activities in teacher-guided teaching, which is suitable for English teaching. This paper explores the application mode of blending teaching in college English teaching. Teaching practice shows that blending teaching with innovative ideas can provide good teaching effect to college English teaching. 
Study on Gesture Use of English Learners under Different Task Difficulty
Authors: Jiang Meng , Song Yu
Published: September 2020

Language is an important tool for people to communicate. In addition to language, body movements and facial
expressions can also convey certain information, which is commonly known as body language. The coordination of
words and gestures enriches the transmission of emotional information. The coordination between language and gesture
further increases the vividness of information transmission and the listener can also get richer information from it, so as
to clarify the speaker's deeper intention. From this point of view, the combination of language and gesture has certain
research value. Based on this, this paper mainly studies learners' gestures in the process of English learning and further
explores their relationship with the difficulty of tasks.
Restrictive Factors and Countermeasures on the Benefits of Financial Precision Poverty Alleviation
Authors: Chen Jieyu
Published: September 2020

Poverty has always been an important issue in China’s economic development. Finance is an important force to promote economic development, and targeted poverty alleviation through finance is a good way to reduce poverty. Although the poverty alleviation and reduction work has made achievements in recent years, it is undeniable that there are still many constraints. This article proposes corresponding solutions to these factors starting from the subjective and objective constraints of the financial precision poverty alleviation benefits.
Las cinco grandes dimensiones de la personalidad
Authors: Laak Jan J. F. ter
Published: September 2020

Este artículo revisa las distintas posiciones teóricas sobre las cinco grandes dimensiones de la personalidad, mostrando las semejanzas y diferencias entre las posturas teóricas. Esta contribución presenta lo siguiente: (a) la génesis del contenido y la estructura de las cinco dimensiones; (b) la fortaleza de las cinco dimensiones; (e) la relación de las cinco grandes dimensiones con otros constructos de personalidad; (d) discute el valor predictivo de las puntuaciones del perfil de las cinco dimensiones para criterios pertinentes; (e) analiza el estatus teórico de las cinco dimensiones; (f) discute críticas históricas sobre las cinco grandes dimensiones y se formulan respuestas a estas críticas; (g) hace conjeturas para el futuro de las cinco grandes dimensiones; y (h) concluye con algunas conclusiones y comentarios.
The cascade stomach in girl 11 years old
Authors: Artamonov Rudol’f G. , Alieva E. I , Glazunova L. V , Polyakov M. V
Published: September 2020

The article presents observation of case of cascade stomach being accompanied with number of dyspeptic phenomena and abdominal pain in girl of 11 years old.
One step forward, two steps back
Authors: Shabalov N. P , Erman L. V , Vaganov P. D , Donetskova Al’mira D.
Published: September 2020

The article presents the history of Russian system of maternity and children care, including pediatric education organized for the first time in the world. the particular considerations concerning post-graduate training are exposed.
The sphincter-preserving resection of rectum with distal sacrumectomy
Authors: Tsarkov P. V , Tulina I. A , Leontyev Aleksandr V. , Puzakov K. B , Zhurkovskiy V. I
Published: September 2020

The described observation is demonstration of sphincter-preserving resection of rectum with distal sacrumectomy under locally widespread cancer of rectum with isolated involvement of distal portion of sacrum and absence of data proving affection of sphincter.
The disease (syndrome) of Marchiafava-Bignami
Authors: Damulin Igor’ V. , Strutsenko A. A
Published: September 2020

The article considers etiopathogenetic, clinical, diagnostic and therapeutic aspects (characteristics) of disease (syndrome) of Marchiafava-Bignami. It is emphasized that this condition in most of the cases is related to chronic alcoholism though it can occur and under other diseases (diabetes mellitus, sepsis, etc.). Despite to previous opinion about inevitable lethality of disease (syndrome) of Marchiafava-Bignami, broad implementation in clinical practice of methods of neurovisualisation and especially NMR technique, demonstrated that this disease can have not so negative prognosis, It is not excluded that in medical clinical practice more light forms of disease (syndrome) of Marchiafava-Bignami are not diagnosed. The differentiated diagnostic is implemented in relation to a number of neurological diseases, including acute disorders of cerebral circulation, lymphoma, multiple sclerosis. The results of NMR of brain play major role in proper diagnostic of disease (syndrome) of Marchiafava-Bignami. The treatment of disease requires vitamins of group B, especially vitamin B1 (thiamine) and corticosteroids. However, estimate of effectiveness of similar treatment requires further investigations.
The use of corrective Chenot corset in the treatment of idiopathic scoliosis in children and adolescents
Authors: Shavyrin Iliya A. , Levkov Vitaly Yu. , Lobov Adry N.
Published: September 2020

Aim. The aim of the study is to evaluate the effectiveness of using a Chenot corset in the treatment of idiopathic scoliosis in children and adolescents.
Materials and methods. Thirty-five patients aged 7 to 17 years, suffering from idiopathic scoliosis degree II-III, under our supervision, were included. The distribution according to gender was 8 boys and 27 girls. The range of the angle of scoliotic deformation before the appointment of the corset was from 21 to 47 degrees according to Cobb on the anterior-posterior x-ray of the spine performed standing. The average angle of deformation was 32 degrees.
Results. Evaluation of the effectiveness of corset therapy was carried out after the patient had adapted to the orthosis (3 months after the appointment of the corset) and reached a wearing time of 1821 h per day on an x-ray of the spine performed in a standing corset. The average correction was 37.5%, and the average angle of deformation was reduced from 32 to 20 degrees.
Comparative analysis of bone volume in the anterior region in patients with protrusion and normal tooth inclination based on CBCT
Authors: Kopetskiy Igor’ S. , Slabkovskaya Anna B. , Kabisova Galina S. , Meskhiya Nana G.
Published: September 2020

The introduction of cone beam computed tomography (CBCT) methods allow to most accurately visualize the bone structures of the maxillofacial region, which enables the specialist to obtain a detailed 3D model of the jaws and teeth with a fairly high resolution.
This article provides the use of computed beam tomography method in orthodontic practice to analyze the initial thickness of bone tissue at various levels of the root length of the frontal group of teeth during their retrusion and protrusion. The calculation results allow us to draw conclusions about the volume of bone tissue and the possibility of orthodontic manipulations. The results of the study significantly improve the diagnosis and planning of orthodontic treatment for pathology in the frontal jaw.
Fulminant diabetes mellitus and concomitant enterovirus infection: a clinical case
Authors: Saprina T. V. , Musina N. N. , Vtorushin S. V. , Krakhmal’ N. V. , Rogovskaya Yu. V.
Published: September 2020

Fulminant type 1 diabetes mellitus is a subtype of diabetes mellitus. It is characterized by the extremely rapid development of hyperglycemia and ketoacidosis because of the near-total destruction of pancreatic -cells. A clinical case of lethal, type 1, fulminant diabetes mellitus is presented. The patient management strategy and possible causes of the adverse course and outcome of the disease are analyzed.
Use of endogenous cholesterol and its metabolite as markers of cyp450 metabolic activity
Authors: Smirnov V. V. , Krasnykh L. M. , Vasilenko G. F. , Ramenskaya G. V. , Checha O. A.
Published: September 2020

This article analyzes the application of the method for determining the activity of CYP3A4 by determining the concentration of endogenous cholesterol and its metabolite/4-hydroxycholine in blood plasma. It also provides information on the convergence assessment of data obtained using alternative methods for determining the activity of the same CYP450 isoenzyme (CYP3A4) using different substrates: cholesterol and cortisol.
Falls in the elderly due to vestibular dysfunction: clinical and pathogenetic aspects
Authors: Damulin I. V. , Tardov M. V.
Published: September 2020

This article discusses the clinical features and causes of falls in the elderly due to vestibular dysfunction. The sociomedical significance of this problem is emphasized. Almost 50% of older people who have suffered repeated falls have a restriction of physical activity because of psychological reasons (fear of repeated falls). The most common cause of falls is balance disorders, and the corresponding complaint in patients with falls is vertigo. The description of peripheral and central forms of vertigo is provided. The clinical and pathogenetic aspects of these disorders are considered. It emphasizes that research conducted in recent years using methods of functional neuroimaging has significantly advanced our understanding of the mechanisms of functioning of the vestibular system, especially its central parts. Based on the results of studies aimed at studying the human connectome in patients with cochleovestibular disorders, the significance of multimodal sensory integration disorders with this pathology is shown.
The role of positron emission tomography combined with computed tomography in the diagnosis and evaluation of treatment effectiveness of non-small cell lung cancer
Authors: Meshcheryakova Nadezhda A. , Dolgushin M. B , Davydov M. M , Laktionov K. K , Odzharova A. A , Nevzorov D. I , Eremin N. V
Published: September 2020

Single photon emission computed tomography (SPECT) with the use of various tumor-tropic radiopharmaceutical preparations (RFP) has shown its effectiveness in the identification of tumor process in the lungs and metastatic lesions of mediastinal lymph nodes. In lung cancer such RFPs as Technetium-99m methoxy isobutyl isonitrile (MIBI) I) and 99mTc-depreotid got the largest traction. Increasingly frequently for the initial assessment of the prevalence ofprimary non-small cell lung cancer (NSCLC) there was used positron emission tomography combined with computed tomography (PET/CT) with 2-[18F]Fluoro-2-deoxy-d-glucose ([18F]FDG). The combined PET/CT image consider metabolic and morphological data, that allows to localize precisely the dissemination of the process and is used for the confirmation of the stage, detection of metabolically active extrathoracic lymph nodes, including those of the standard size (
Rebiopsy in IV stage non-small-cell lung cancer patients after systemic therapy
Authors: Yudin Denis I. , Anteev A. A , Marinov D. T , Ardzinba M. S , Laktionov K. K
Published: September 2020

Rebiopsies are not performed in currently clinical practice for the patients with advanced non-small cell lung cancer (NSCLC). However, identification of as an activating mutation, as other molecular and genetic disorders can considerably change management and prognosis for these patients. Twenty-nine patients with advanced NSCLC after systemic therapy were rebiopsied and samples were studied for a limited range of genetic alterations (sensitizing EGFR mutations, T790M, KRAS gene mutations, translocation of ALK, ROS1, expression PD-L1). Results were used for making decision on further treatment.
Effect of hyperthermia on the viability and proliferative activity of tumor cells
Authors: Anisimova N. Yu , Kiselevskiy M. V , Abdullaev Amir G. , Malakhova N. V , Sitdikova S. M , Polotskiy B. E , Davydov M. M
Published: September 2020

Introduction. Results of the systemic chemotherapy in the peritoneum canceromatosis are unsatisfactory because of poor penetration of anticancer drugs in serous cavities due to the presence ofperitoneal-plasma barrier. One of the possible ways to enhance the action cytostatic agents is the use of chemotherapy and hyperthermia, which, according to some data, has an own cytotoxic effect. The purpose of the study. The study of the effect ofdifferent modes of hyperthermia on the physiological activity of transplantable lines of tumor and non-transformed cells. Results. Analysis of the impact of hyperthermia on the physiological activity of transplantable lines of tumor and the non-transformed cells in vitro and in vivo studies demonstrated that along with the gain in the level and time of the temperature exposure as the degree of damage as tumor cell mortality rate increases. In this study the most effective treatment was as follows: the temperature is above 45°C with the exposure of more than 2 hours, which is difficult to achieve in practice due to the limited tolerance of healthy tissues. Conclusion. With the use of hyperthermia in monoregimen it is not possible to achieve effective levels of the temperature impact, which could hardly have a significant inhibitory effect on tumor cells.
Malignant neoplasms: the age peculiarities of the epidemiology of primary disability in the Russian Federation
Authors: Shurgaya Marina A.
Published: September 2020

The article is devoted to the problem of primary retirement due to malignant neoplasms in the adult population in the Russian Federation. There are presented results of a study of the dynamics (2005-2014) of the age-gender structure, level and severity of primary disability due to this socially significant disease. The ranking of subjects of the Russian Federation according to the intensive index, describing the prevalence of primary disability due to malignant neoplasms is presented also. Over the ten-year period the maximum number for the first time recognized as disabled (FTRD) was revealed to be observed in 2005, amounting to 200.4 thousand people, with a subsequent decrease to 170.2 thousand people in 2008. However, later the trend in the dynamics changed to the increase in the total number of FTRD due to malignant neoplasms and the gain in the index accountedfor 13% in comparison with 2008. In the age pattern of disability due to malignant neoplasms there are dominated elderly invalids (60.3 %), among which there are prevailed the invalids of the group I (31.2%) and group II (53.6%). The area with the lowest level of the primary disability due to malignant neoplasms among the population of elderly is the Sakhalin region (15.4 per 10 thousand of the elderly population). The greatest prevalence of malignant neoplasms occurs in the Kurgan region (52.3 at the average rate of 34.4 per 10 thousand of the elderly population). Also the unfavorable situation in the Kaluga region, the Republic of Kalmykia, Novosibirsk, Bryansk, Orenburg and Arkhangelsk regions (46.9-45.1) per 10 thousand of the elderly population), which requires measures for the effective prevention of primary disability due to this socially significant severe disabling pathology.
Phyto-anti-estrogens are potential selective modifiers of biological reactions in breast cancer
Authors: Borisova Juliya A. , Smirnova G. B , Shubina I. Zh , Shprakh Z. S , Treshchalina E. M
Published: September 2020

The review analyzes up-to-date information about specific characteristics of anti-estrogen therapeutic agents with different mechanisms of action with regard to present knowledge of endocrine therapy for estrogen-positive breast cancer (ER+ BC). The paper presents some agents for anti-estrogen therapy of breast cancer - aromatase inhibitors and selective modifiers of biological reactions (SMBR) and their mechanisms of anti-proliferative action. The authors describe significant therapeutic and side effects as well as different options for anti-estrogen combinations. Special emphasis is made on national herbal estrogens/anti-estrogens that have no toxicity associated with the well-known SMBRs. The review presents the structure and characteristics of a perspective phyto-anti-estrogen sekoizolaricirezinol (SEKO), which demonstrated significant anti-proliferative activity with no pro-estrogen action in the in vivo models of ER+ BC.
INTRATUMORAL STROMAL MAST CELLS IN RENAL CELL CARCINOMA: CLINICAL AND MORPHOLOGICAL COMPARISONS
Authors: Kazarcev A. V , Cherdanceva T. M , Bobrov I. P , Lazarev A. F , Klimachev V. V.I
Published: September 2020

In the work there was investigated the prognostic value of the counting of intratumoral stromal mast cells (MC) in renal cell carcinoma. Tissue samples were obtained intraoperatively from 63 patients with renal cell carcinoma. The average age of patients accounted for 58.2 ± 12 years. There were observed 34 (54%) men and 29 (46%) women. There were revealed correlation relationships between the density of distribution of mast cells in tumor and the clinical stage of the disease (r = 0.69; p = 0.0001), tumor nodule size (r = 0.58; p = 0.0001), the presence of regional and distant metastases (r = 0.48; p = 0.0001), tumor grade according to the criteria of Fuhrman (r = 0.89; p = 0.001), and postoperative survival of patients (r = 0.40; p = 0.001). There was found no interrelationship between the number of MC in tumor with the gender (r = -0.03; p = 0.8), age (r = -0.15; p= 0.25), and the histological type of tumor (r = 0.16; p = 0.19). The gain in the number of intratumoral stromal MC in carcinoma can be considered as a predictor of the possible appearance of metastases. The high amount of MC in tumor has been shown to correlate with a poor prognosis of the patients with renal cell carcinoma.
ANALYSIS OF THE INTERRELATION OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR WITH PITUITARY ADENOMAS COMPLICATED BY PITUITARY APOPLEXY
Authors: Makhkamov K. E , Azizov Miralib M. , Vervekina T. A , Nishonov D. A
Published: September 2020

Aim. Despite the fact that the pituitary adenoma is a relatively benign tumor, sometimes the course of the disease is complicated by intramedullary hemorrhage. In the world literature there are single data on the molecular mechanism of hemorrhage in the adenomas of the pituitary gland. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis and permeability of the endothelium in various brain tumors. There was made an analysis of the relationship between pituitary apoplexy and VEGF expression in pituitary adenomas. Material and methods. Immunohistochemical investigation of the level of expression of the molecular-biological marker - VEGF was performed with the use of monoclonal antibodies with the method of semiquantitative analysis in 30 pituitary adenoma patients. In the clinical study data about the age, gender, hormonal activity and X-ray study were studied. There was executed a statistical analysis of the relationship between clinical diagnostic data and VEGF expression. Results. Hormonal active tumors were detected in 12 (40%) cases, intratumoral hemorrhage - in 16 (53.3%), adenomas with cystic component - in 7 (23.3%) and invasion of cavernous sinus - in 22 (73.3%) of cases. Expression of VEGF was observed in 11 cases (36.6%). Based on the analysis the expression of VEGF was found to be closely related to pituitary apoplexy (PA) in pituitary adenomas (p < 0.001). However, there was no statistically significant relationship between VEGF and age, sex, tumor size, hormonal activity, cystic component presence, invasive tumor growth (p > 0.05). Conclusion. It was found that immunohistochemical examination of the level of expression of a molecular biological marker VEGF can be used in the evaluation of the prognosis of the disease or the identification of a risk group with a high probability of the development of pituitary apoplexy and recurrence of tumor growth.