bluuebunny/crossref_metadata_2025 huggingface dataset:
The Hybrid Compounds as Multi-target Ligands for the Treatment of
Alzheimer's Disease: Considerations on Donepezil
Authors: Gulcan Hayrettin Ozan , Kosar Muberra
Published: November 2021

:

The strategies to combat Alzheimer’s Disease (AD) have been changing with respect to the
failures of many drug candidates assessed in clinical studies, the complex pathophysiology of AD,
and the limitations of the current drugs employed. So far, none of the targets, either validated or nonvalidated,
have been shown to be purely causative in the generation and development of AD. Considering
the progressive and the neurodegenerative characteristics of the disease, the main strategy has
been based on the design of molecules capable of showing activity on more than one receptor, and it
is defined as multi-target ligand design strategy. The hybrid molecule concept is an outcome of this
approach. Donepezil, as one of the currently employed drugs for AD therapy, has also been utilized in
hybrid drug design studies. This review has aimed to present the promising donepezil-like hybrid
molecules introduced in the recent period. Particularly, multi-target ligands with additional activities
concomitant to cholinesterase inhibition are preferred.
Neuropharmacological Activity of the New Piperazine Derivative 2-(4-((1-
Phenyl-1H-Pyrazol-4-yl)Methyl)Piperazin-1-yl)Ethyl Acetate is Modulated
by Serotonergic and GABAergic Pathways
Authors: Costa Elson Alves , Almeida Lorena de Souza , Santana Ianca Gontijo Cavalcante , da Silva Moreira Lorrane Kelle , Turones Larissa Córdova , Sanz Germán , Vaz Boniek G. , de Carvalho Flávio S. , Lião Luciano M. , Menegatti Ricardo , de Brito Adriane Ferreira
Published: November 2021

Background:

Pharmacological treatments for mental disorders, such as anxiety and depression,
present several limitations and adverse effects. Therefore, new pharmacotherapy with
anxiolytic and antidepressant potential is necessary, and the study of compounds capable of interacting
with more than one pharmacological target may provide new therapeutic options.

Objectives:

In this study, we proposed the design, synthesis of a new compound, 2-(4-((1-
phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethyl acetate (LQFM192), pharmacological evaluation
of its anxiolytic-like and antidepressant-like activities, as well as the possible mechanisms of
action involved.

Methods:

Administration of LQFM192 was carried out prior to the exposure of male Swiss mice to
behavioral tests, such as the elevated plus-maze and forced swimming test. The involvement of the
serotonergic system was studied by pretreatment with WAY-100635 or p-chlorophenylalanine (PCPA)
and the involvement of the benzodiazepine site of the GABAA receptor by pretreatment with
flumazenil.

Results:

The treatment with LQFM192 at doses of 54 and 162 μmol/kg demonstrated anxiolyticlike
activity that was blocked by WAY-100635, PCPA, and flumazenil pretreatments. The potential
antidepressant-like activity was visualized at the same doses and blocked by WAY-100635 and
PCPA.

Conclusion:

In summary, the anxiolytic-like activity of LQFM192 is mediated by the serotonergic
system and the benzodiazepine site of the GABAA receptor, and the antidepressant-like activity
through the serotonergic system.
Firm supervisory board during pandemic
Authors: Satrio Arif Budi , Kontesa Maria
Published: November 2021

This study investigates public trust in the firm supervisory board, an essential indicator of good corporate governance in some literature. By using 474 non-financial entities in Indonesia during the COVID-19 pandemic and considering a number of firm fundamental factors, this study documents evidence of irrational investor behavior during the pandemic. Investors seem to panic and respond negatively to financial information. However, the public still believes in the independent supervisory board's contribution to the firm. This effect is getting stronger with the presence of an increasingly dominant supervisory board. These results are still robust during repeated testing. This empirical evidence is useful to regulators in emerging markets, industry, and academia.
Author's cinematograph of new Hollywood
Authors: Pogrebniak Galyna P. , Gavran Iryna A. , Honcharuk Serhii M. , Mykhalov Volodymyr Ya. , Kot Halyna M.
Published: November 2021

The paper is devoted to the problems of director's self-fulfilment in the cinematograph of New Hollywood. The study examines such a unique phenomenon of the artistic culture of the 20th century as American author's cinematograph. The relevance of this study is determined by the trends in the development of New Hollywood, which have radically changed the essence of modern cinematograph. The purpose of the study is to identify the specifics of New Hollywood cinema, which resonated in the work of modern Hollywood directors as an influential and competitive area. The main emphasis in this study is placed on the attempts of both historians and film theorists, as well as practitioners themselves to find clear boundaries between American independent and mass Hollywood cinematograph, as well as on the reasons why film critics and culturologists consider a particular American film to be independent, author's, or mass cinema (the so-called mainstream). At the same time, the main areas and trends of American author's cinematograph are studied from the point of view of director's self-fulfilment. Examples from films by American directors and authors were analysed. Methods of scientific analysis, comparison, and generalisation were used in the study of the topic.
Quality Service Provision and Students Satisfaction at Akenten Aooiah-menka University of Skills Training and Entrepreneurial Development: Implications for University management
Authors: Osei-Owusu, PhD Benedict
Published: November 2021

The aim of this study was to investigate the factors that affect quality service provision and students’ satisfaction at Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development. Descriptive survey research was used for the study. Simple random sampling was used to select third and final year undergraduate students in Kumasi and Mampong campuses.The total population of the study was 1642. Parasuram’s SERQUAL instrument type of questionnaire was adopted as a research instrument for data collection. The internal consistency of the 32-items yielded a Cronbach Alpha value of 0.91. The data gathered were quantitatively analysed with the use of descriptive and inferential statistics. The results of the study showed a statistically strong and direct relationship between quality in commitment, social and financial bonds, communication, general academic conditions and administrative support and students’ satisfaction which in turn influenced institutional image and students’ loyalty. This indicates that students had high expectations in the five-dimensional variables that stood as proxy for quality service provisions by the University. It was recommended that university management should appoint competent academic and administrative staffs to positions, provide them with adequate professional development programmes to improve their commitment in teaching and learning, communication and other service provisions. More so, management should be proactive towards adequate infrastructural provision for students in order to improve their academic work in a conducive learning environment. Lastly, the study will benefit other universities in Ghana to identify cost effective ways of improving service quality provision.
IN VITRO ASSESSMENT OF PHYSICOCHEMICAL PARAMETERS OF FIVE GENERICS AMLODIPINE BESYLATE TABLETS MARKETED IN YEMEN
Authors: ALSHARGABI ARWA
Published: November 2021

Objective: The present paper aims to evaluate the quality of five different brands (local and imported) of oral film-coated tablets of generic Amlodipine besylate 5 mg marketed in Sana`a-Yemen, through physiochemical parameters. Methods: Different physicochemical parameters, including the uniformity of tablet weight, hardness, thickness, disintegration time, and an assay of active ingredients, were conducted to validate the quality of generics Amlodipine Besylate 5 mg according to USP specification. Results: From the obtained results, it was observed that all the brands of Amlodipine Besylate 5 mg have passed the tests and met the specifications of USP. Results of weight variation, hardness, thickness, and disintegration time were ranged from-3.8 % to+5.13 % to-1.25 % to+3.25 %, 5.06±0.31 to 13.21±1.5, 2.682±0.04 to 3.676±0.01 and 25 s to 2 min: 30 s, respectively. The dissolution test and the assay results of all the brands are also ranged within the acceptable label claim 93.7±2.24 to 98.4±0.85 and 93.22±0.38 to 100.15±0.33, respectively. However, there is no relation was found between the disintegration time and the dissolution test. Conclusion: According to the finding, all the selected Amlodipine Besylate 5 mg brands are met pharmacopeia standards and USP specifications. Therefore, the local and imported Amlodipine Besylate 5 mg can be used safely to get the desired therapeutic efficiency.
ZA USTANOVLJENJE I OZVANIČENJE SRBISTIKE
Authors: Milosavljevic Vera
Published: November 2021

U sistemu slavistike kao naučne filološke discipline pre tri decenije nije postojao podsistem sa imenom srbistika. Postojao je podsistem serbokroatistika (za oblast proučavanja jezika) i jugoslavistika (za oblast proučavanja književnosti). To je potvrđeno u knjizi Predraga Pipera Uvod u slavistiku objavljenoj u Beogradu 1991. godine (Piper 1991, 8). Iste godine kada i Piperova, izašla je knjiga Radmila Marojevića Ćirilica na raskršću vekova i u njoj je, samo na jednom mestu, pomenuto ime srbistika (Marojević 1991, 131). Pet godina kasnije, na Filološkom fakultetu u Beogradu održan je simposion Sopostavitelьnыe, tipologičeskie i sravnitelьno-istortičskie issledovaniя russkogo i drugih яzыkov (25-29. septembra 1996). U okviru ovog naučnog skupa organizovan je u Novom Sadu okrugli sto Russkiй яzыk. Russistika. Serbskiй яzыk. Serbistika. Na traženje čuvenog ruskog lingviste akademika Oljega Trubačova, učesnika simposiona, okrugli sto je održan u Gimnaziji „Jovan Jovanović Zmaj“ radi sećanja na slavnog Pavela Jozefa Šafarika, koji je bio profesor i direktor Srpske pravoslavne velike gimnazije u Novom Sadu (1819-1833) a čiju tradiciju nastavlja sadašnja, popularno zvana, Jovina ili Zmajeva gimnazija. Pavel Jozef Šafarik je bio jedan od nosećih stubova u razvoju slavistike i srbistike u prvoj polovini 19. veka. Ovom prilikom, profesor Metodologije proučavanja književnosti na Filozofskom fakultetu u Novom Sadu Petar Milosavljević podneo je referat Srbistika – stanje i perspektive koji je potom objavljen kao Pogovor u njegovoj knjizi Srbi i njihov jezik (Priština 1997). Iste 1996. godine, predstavnik nove istoriografske škole u Srba Jovan I. Deretić osnovao je u Čikagu Institut za srbistiku koji nije bio dugog veka jer se njegov osnivač ubrzo vratio u Srbiju.
PRAVDA, PRAVO I ETIKA SILE
Authors: Rados Jovo
Published: November 2021

Okupacija Republike Srpske Krajine, teritorije koja je bila pod zaštitom Ujedinjenih nacija , i koja je završnom vojnom akcijom hrvatskih snaga obavljena pre dvadeset i pet godina (od 04. do 05. VIII 1995.) smatra se, sve do danas, (od strane Hrvatske i njoj naklonjenih zemalja), regularnom, legitimnom i istorijski okončanom činjenicom. Nažalost, to postojeće faktičko stanje, protok vremena i obuzetost raznim drugim egzistencijalnim problemima, doveli su do toga da su i mnogi pripadnici srpskog korpusa zanemarili ovo pitanje, a određeni pojedinci su, u međuvremenu, svojim nerazumnim ponašanjem, još i „legli na rudu“ hrvatskog opravdavanja zločinačke akcije „Oluje.“ Malo-pomalo, zaboravlja se šta se, zapravo desilo, kakav je zločin učinjen nad našim narodom i šta znači gubitak vekovnih srpskih prostora, sa kojih je prognano (ili se pod pritiskom iselilo preko 800 000 Srba). Temeljno etničko čišćenje, kao i današnji neshvatljivo težak položaj preostalog srpskog stanovništva u Hrvatskoj, uopšte ne dotiču takozvanu međunarodnu zajednicu, koja je svoje dvostruke standarde prema nama ispoljavala (odnosno, ispoljava) i u mnogim drugim situacijama. Demokratija koju kreiraju svetski moćnici (a deklarativno i licemerno je primenjuju i pravdaju kada je u pitanju srpski narod), uglavnom podseća na „demokratiju u dometu mazginog užeta“ (Borislav Pekić). U tom smislu, i Dobrica Ćosić (kao predsednik SR Jugoslavije), u svojoj knjizi Kosovo, na jednom mestu sa očiglednom razočaranošću kaže: „Svet je svirep, podao, pokvaren.“
USPOSTAVLJANJE KULTA LIČNOSTI U SEVERNOJ KOREJI I NARODNOJ REPUBLICI KINI: UPOREDNA ANALIZA DVA MODELA VLASTI
Authors: Simic Savo
Published: November 2021

U ovom radu pokušaćemo da odgovorimo na pitanje po čemu se razlikuju dva uspostavljena kulta ličnosti u Severnoj Koreji i Kini. Pre svega ispitujemo šta se podrazumeva pod kultom ličnosti i koje su njegove inherentne karakteristike prema izlaganju tematskih autora. U toj nameri ćemo napraviti distinkciju u obrazlaganju istorijskog oblika sa moderno izgrađenim kultom ličnosti. Potom se fokusiramo na analizu uspostave savremenog kulta u Severnoj Koreji pod uticajem Kim Il Sunga i Mao Cedunga u susednoj Narodnoj Republici Kini. Razlozi za komparaciju su mnogobrojni. Vremenska odrednica formiranja kulta ličnosti u navedenim državama je slična, politički uslovi u kojima su nastali i oblik vlasti formiran prema modelu Sovjetskog Saveza kao zajednički imenitelj oba režima. Istraživačke metode podrazumevaju upotrebu analize sadržaja pri obradi pojedinih govora, dokumenata u uspostavi bazičnih elementa kulta ličnosti i komparativnu analizu pri određenju i poređenju sličnosti i razlika između dva uspostavljena kulta.
CHALLENGES OF LEADERSHIP AND FOLLOWERSHIP IN NIGERIAN GOVERNANCE ARCHITECTURE: AN ANALYTICAL REVIEW
Authors: Mohammed Nasiru Ibrahim , Salisu Ogbo Usman , Abdullazeez Osuwa Abdullahi , Olufemi Akinrinde Olawale
Published: November 2021

The paper examines the challenges of leadership and followership in governance and how poor leadership has undermined democratic and sustainable development in Nigeria. Specifically, it explores reasons why one of the world most endowed nations in human capacity continues to be bequeathed mis-governance. Using documentary approach, we argue that the challenges for poor leadership and followership in Nigeria’s contemporary political system are tied to corruption and self-aggrandizement of leaders and followers with unquenchable self-centeredness coupled with a crop of leaders without vision towards the betterment of the country. We conclude however that Nigerians should focus on electing leaders with proven track records of selfless service, achievement towards geared sustainability and developmental stride for efficiency, effectiveness and higher productivity. If this was done in line with the intent to salvage the crumbling political system, there would be renewed value orientation that is required to make Nigerians more politically responsible to the country.
DOPRINOS EVROPSKE SLUŽBE ZA SPOLjNO DELOVANjE MEĐUNARODNOJ PRAKSI ODRŽIVOG RAZVOJA
Authors: Djurcevic Cucic Miljana
Published: November 2021

Rad razmatra institucionalne promene u Evropskoj uniji (EU) čije realizovanje započinje stupanjem na snagu Ugovora iz Lisabona čime se omogućava da EU na globalnom planu a posebno pri glavnom multilateralnom okviru Ujedinjenih nacija (UN) diplomatski deluje na stvaranju saglasnosti za definisanje međunarodne prakse održivog razvoja. Fokus je na formiranju Evropske službe za spoljno delovanje (ESSD) koja je od Ugovora iz Lisabona novo osnovno telo za pružanje podrške celokupnom diplomatskom delovanju EU. Osnovna pretpostavka na kojoj se rad zasniva jeste da EU osnivanjem ESSD započinje svojevrsnu objedinjujuću diplomatiju kojom vodi uspostavljanju međunarodne prakse održivog razvoja. Svi odnosi, procesi, strukture, delovanja i akterske jedinice posmatraju se kroz prizmu teorije prakse vođenja diplomatije i posebno u njoj oblikovano razumevanje zajednice praksi čijom se primenom postiže osvetljavanje zajedništva delovanja EU vođenjem objedinjujuće diplomatije Evropske komisije i Visokog predstavnika koje svojim radom podržava ESSD. Jedan od doprinosa diplomatskih aktivnosti ESSD politici održivog razvoja prepoznaje se i u prenošenju nadležnosti upravljanja Evropskom mrežom zelene diplomatije na ESSD 2012. godine. Zaključnim razmatranjima navodi se da ESSD jeste činjenično osnovana kao prvo autonomno funkcionalno telo EU i prvo zajedničko telo za podršku vođenju diplomatije EU. Kao takvo telo ključan je akter od koga polaze sve diplomatske aktivnosti i drugih institucija EU, a koje bez stručne i ekspertske podrške ESSD ne bi uspešno obavljale svoje zadatke. Iako ne apsolutno samostalna ova služba je značajan točak u mehanizmu uspostavljanja međunarodne prakse održivog razvoja.
Wetland landscape based on Sentinel-2 images and geo-tagged photographs in Centla, Tabasco
Authors: López-Caloca Alejandra Aurelia , Morales Gamas Amilcar , López Aguilar María Gabriela
Published: November 2021

This is an analysis of the geographic landscape in the Centla wetlands of Tabasco, Mexico. A map shows the use of remote sensing data combined with easily understood and conveyed visual descriptive data which show the ecological conditions of the landscape. The central map of this article presents a land use and land cover study, obtained from Sentinel-2 MSI data for the Centla wetland zones. The support vector machine algorithm is used to classify Sentinel-2 images. The results show a high general precision of 90.0%, as well as high precision in separating types of wetlands. Information obtained during fieldwork at the ground level is inserted in the map, comprised of photos taken with a mobile application along the Grijalva and the San Pedro y San Pablo rivers. These photos provide visual verification of the map.
Simulation Analysis of Circuit and Designing of PCB Layout of a CMOS based NOR Logic Gate using Open-Source Software eSim
Authors: Eppili Balakrishna
Published: November 2021

Abstract: There are various basic gates like NAND, NOR gates which are extensively used in the designing of the more complex circuits with use higher number of transistors such as MUXs, ADCs and any other circuits. In this paper, we have carried out the modelling of NOR gate at 130 nm technology, yet maintaining comparable performance than conventional CMOS NOR gate logic structure. The modelling includes schematics design and PCB layout design run of the above gates. Also, the simulation results of the gates are obtained at the same node with start time, step time, stop time, rise time, fall time and delay and power dissipation. In this all process have been carried out of a CMOS based NOR Logic Gate using Open-Source Software eSim. Keywords: Simulation, PCB, NOR, CMOS, eSim
Trata de personas con fines de explotación sexual: Una mirada desde el ordenamiento jurídico uruguayo e internacional
Authors: Fascioli Caorsi Federico
Published: November 2021

El presente trabajo tiene como objeto analizar qué se entiende por trata de personas, especialmente aquella que tiene fines de explotación sexual, a la luz de la normativa uruguaya e internacional. En el Derecho Internacional se encuentra una moderna definición de trata de personas en el art. 3 lit. a del Protocolo para prevenir, reprimir y sancionar la trata de personas, especialmente mujeres y niños. Por otro lado, en el ordenamiento jurídico uruguayo hay dos definiciones del fenómeno. En orden cronológico, la primera está consagrada en el delito previsto en el art. 78 de la ley n.° 18.250 (Ley de Migraciones), mientras que la segunda está inserta en el art. 4 de la ley n.° 19.643 (Ley de Prevención y Combate de la Trata de Personas. Modificaciones al Código Penal). El análisis de estas tres definiciones permitirá calificar correctamente una situación de trata de personas. Pero, para comprender este fenómeno, también es necesario distinguirlo de otro de similares características: el tráfico ilegal de migrantes. Por último, se analizan casos de jurisprudencia, con el objetivo de entender cómo los jueces uruguayos han aplicado las normas jurídicas sobre esta temática en situaciones concretas.
Rizaeddin Fakhraddin (1859‒1936) on Model of State of the Modern Epoch
Authors: Khabutdinov A. Yu.
Published: November 2021

This article is devoted to the ideas of Rizaetdin Fakhretdin (1859‒1936) concerning the statehood of the Late Modern (19th century) period. His main theological work “Dini ve ĳtimagy meseleler” (“Religious and Social Issues” (1914)) was devoted to the justification of the modernization reforms as well as to ways of their understanding from the Muslim point of view. R. Fakhraddin analyzed reforms of the political and legal system, the introduction of the Constitution, the construction of the rule of law, the creation of Parliament. He justified the necessity and legitimacy of these reforms from the point of view of the Qur’an and the Sunnah.
In Memory of Vladimir Gerdt
Authors: Edneral Victor F.
Published: November 2021

Center for Computational Methods in Applied Mathematics of RUDN, Professor V.P. Gerdt, whose passing was a great loss to the scientific center and the computer algebra community. The article provides biographical information about V.P. Gerdt, talks about his contribution to the development of computer algebra in Russia and the world. At the end there are the authors personal memories of V.P. Gerdt.
Features of the Development of the Modern Finnish Feminist Movement
Authors: Pogodin S. N. , Sablina M. A.
Published: November 2021

The Finnish state has created a high level of social protection for its women. Thanks to social support, Finnish women have become economically independent and have been given the opportunity for personal and professional development. Gender equality is inextricably linked to democracy, human rights and social justice. The Finnish state actively supports the women’s movement and in particular feminist organizations. The process of involving women in politics was slow. The first feminist party, Feministinen puolue, is active in Finland.
La corrupción a gran escala no tipificada en el ordenamiento colombiano: análisis desde los escenarios jurídicos y categorías de corrupción
Authors: Pino Cañaveral Leonidas Alberto , Garcés Medrano Alex , Duarte Molina Tirson Mauricio , Mambuscay Burbano Juan David
Published: November 2021

El presente artículo tiene por objetivo describir la corrupción como un fenómeno social que surge entre las relaciones del Estado como regulador y los particulares como destinatarios a partir de la imbricación de diferentes acciones, particularmente de la legitimidad institucional en las esferas pública y privada. Metodológicamente se toma como referencia la tipificación penal para efectos de establecer los escenarios posibles (públicos y privados) donde se ejecutan acciones de corrupción en varios niveles. Se analiza cada delito conforme a una escala mínima, media o amplia que sirva de insumo para comprender la dinámica de la corrupción y su relación con el Estado. A este fin se vincula una noción propia de corrupción a gran escala, instante poco analizado y de suma importancia para el ordenamiento jurídico colombiano. Se encuentra, entonces, que las situaciones materiales no encuentran correspondencia punitiva con la norma existente o desbordan sus límites entre los delitos tipificados. Por ello, instan por su inclusión como modalidad específica.
PRODUÇÃO CIENTÍFICA RELACIONADA AO FUTEBOL DE MULHERES EM TESES E DISSERTAÇÕES BRASILEIRAS NA ÁREA DA EDUCAÇÃO FÍSICA
Authors: Beirith Mariana Klauck , Araldi Franciane Maria , Folle Alexandra
Published: November 2021

Objetivamos mapear e explorar a produção científica relacionada ao futebol de mulheres em teses e dissertações brasileiras, na área de conhecimento da Educação Física, na última década. Os trabalhos foram rastreados no Banco de Teses e Dissertações da Capes, do IBICT e do NUTESES, através da equação Futebol and feminino or Mulher. Os resultados encontrados consistem em: nove dissertações e duas teses; 11 pesquisadores (majoritariamente mulheres); destaque ao ano de 2017; apenas as regiões Sul e Sudeste foram contempladas; sete instituições que possuem estudos na temática; subárea pesquisada com mais frequência foi a sociocultural, com palavras-chave relacionadas a ela; a maioria dos trabalhos não contou com financiamento. Tais resultados expressam a necessidade de investimento nas pesquisas e de PPG fora dos polos tradicionais acadêmicos brasileiros. A pesquisa reflete a incipiência da produção científica nacional sobre o futebol de mulheres, justificada pelos seus impactos históricos, sociais e culturais.
Propuesta de planeación estratégica como herramienta de competitividad aplicada al emprendimiento Cotton Candy de la ciudad de Cartagena de indias, Colombia
Authors: Otero Tapia Amalio Segundo , Ariza García Engler de Jesús , Castillo Giraldo Roy Antonio , Lombana Moron Carlos Mauro , Fuentes Padilla Jhosman
Published: November 2021

Cada día son más las empresas que compiten en el mercado, es un gran número de ellas que luchan por crecer, mantenerse y ocupar un lugar privilegiado, de igual manera es un número bastante considerable las que cierran sus puertas y fracasan, muchas otras tienen que replantear lo que hacen para no desaparecer. En el presente artículo se muestra la importancia de la planeación estratégica como una herramienta fundamental para direccionar el actuar de la organización, tomando el caso del emprendimiento Cotton Candy, ubicada en la ciudad en Cartagena de Indias en el departamento de Bolívar- Colombia, con el fin de proponer estrategias que permitan el desarrollo y competitividad de este emprendimiento, buscando su crecimiento y visibilidad en el mercado.
Crimean Congo hemorrhagic fever in the COVID-19 pandemic: a case study
Authors: Mardani Masoud , Aghazadeh Kouros , Nikpour Shahriar , Hakamifard Atousa
Published: November 2021

In the COVID-19 pandemic, the overlap of clinical features between the
other viral infections, make a reliable diagnosis difficult in the
initial stage of illness. We describe the first confirmed case of CCHF
in Tehran province during this year, who first misdiagnosed as COVID-19
infection.
Association Between Posture and Quality of Life: Implications for Children with Cancer
Authors: Raybin Jennifer , Hendricks-Ferguson Verna , Hernandez Teri
Published: November 2021

Background: Children with cancer experience decreased quality of life.
The National Institutes of Health has recommended examination of quality
of life factors to promote development of clinical interventions to
reduce suffering. Measuring quality of life in children based on
self-report instruments is limited by subjectivity, age, and
developmental stage. Assessment of posture is a pioneering objective
physical measure that may augment quality of life preceptions among
individuals with cancer. Procedure: This systematic literature review
synthesized published evidence regarding the relationship between
posture and quality of life. A systematic search using PRISMA guidelines
identified articles describing studies of human subjects that included
the variables of a) posture measured by the standard thoracic kyphosis
angle; and b) quality of life or depression/mood. A total of 14 eligible
studies met inclusion criteria (published 2000-2018). Studies were
graded for level of evidence and themes were identified. Results: No
studies were found in children with cancer. The majority of the studies
(8 of 14) were rated at the moderate level. Key review findings include
evidence supporting: 1) a consistent bidirectional relationship between
posture and quality of life; 2) that when posture improves, quality of
life also increases; and when depression decreases, posture improves;
and 3) emotion is expressed through posture. Conclusion: If posture is a
sensitive and precise measure of quality of life, it could strengthen
existing measurements and give a more complete picture to in turn
identify children who may benefit from supportive care interventions
during cancer treatment.
The comparative energetics of the turtles and crocodiles
Authors: Marn Nina , Kooijman Sebastiaan
Published: November 2021

The Add-my-Pet (AmP) collection of data on energetics and Dynamic Energy
Budget (DEB) parameters currently contains 92 species of turtles and 23
species of crocodiles. We discuss patterns of eco-physiological traits
of turtles and crocodiles, as functions of parameter values, and compare
them with other taxa. Turtles and crocodiles accurately match the
general rule that the life-time cumulated neonate mass production equals
ultimate weight. The weight at birth for reptiles scales with ultimate
weight to the power 0.6. The scaling exponent is between that of
amphibians and birds, while that for mammals is close to 1. We explain
why this points to limitations imposed by embryonic respiration, the
role of water stress and the accumulation of nitrogen waste during the
embryo stage. Weight at puberty is proportional to ultimate weight, and
is the largest for crocodiles, followed by that of turtles. These facts
explain why the precociality coefficient – approximated by the ratio of
weight at birth and weight at puberty at abundant food – decreases with
ultimate weight. It is the smallest for crocodile,s because of their
large size, while that lizards and snakes are much larger than for
turtles. The maximum reserve capacity in both turtles and crocodiles
clearly decreases with the precociality coefficient. This relationship
has not be found that clearly in other taxa, not even in other reptiles.
Crocodiles have a relatively large assimilation rate and, as
consequence, a large reserve capacity. Sea-turtles have a small weight
and age at birth, which we link to reducing risks on the beach.
Temporal refuges differ between human and natural top-down pressures in a subordinate carnivore
Authors: Malhotra Rumaan , Lima Samantha , Harris Nyeema
Published: November 2021

Animals exhibit variation in their space and time use across an
urban-rural gradient. As the top-down influences of apex predators wane
due to human-driven declines, landscape level anthropogenic pressures
are rising. Human impacts can be analogous to apex predators in that
humans can drive increased mortality in both prey species and
carnivores, and impact communities through indirect fear effects and
food subsidies. Here, we evaluate the time use of a common mesocarnivore
across an urban rural gradient, and test whether it is influenced by the
intensity of use of a larger carnivore. Using multiple camera-trap
surveys, we compared the temporal response of a small carnivore, the
raccoon (Procyon lotor), to the larger coyote (Canis latrans) at four
sites across Michigan that represented a gradient of pressure from
humans. We found that raccoon time use varied by site and was most
unique at the rural extreme. Raccoons consistently did not shift their
activity pattern in response to coyotes at the site with the highest
anthropogenic pressures despite considerable interannual variation, and
instead showed the stronger responses to coyotes at more rural sites.
Temporal shifts were characterized by raccoons being more diurnal in
areas of high coyote activity. We conclude that raccoons do partition
time to avoid coyotes. Our results highlight that the variation in
raccoon time use across the entirety of the urban-rural gradient needed
to be considered, as anthropogenic pressures may dominate and obscure
the dynamics of this interaction. In an increasingly anthropocentric
world, to understand species interactions, it is imperative that we
consider the entire spectrum of human pressures that it may occur
within.
Microplastiche: classificazione, identificazione e rimozione all'interno degli impianti di trattamento delle acque reflue
Authors: Petrone Ciro Dario
Published: November 2021

Negli ultimi decenni, l’interesse nel documentare le microplastiche
nell’ ambiente è notevolmente aumentato.  La persistenza delle materie
plastiche nell’ambiente è il principale motivo per cui sono state
identificate come una grave minaccia. Il decadimento naturale degli
oggetti di plastica nell’ambiente richiede un tempo estremamente lungo,
inoltre queste micro particelle possono trasportare altri prodotti
chimici, usati come additivi nella loro fabbricazione, o assorbirli
attraverso la forte capacità di adsorbimento. Questo articolo si
prefissa di dare un contributo alle informazioni sul campionamento,
l’identificazione, l’analisi e la rimozione delle microplastiche ,
identificate come contaminanti emergenti, all’interno degli impianti di
trattamento delle acque reflue che sono considerati   una fonte
importante per l’immissione delle microplastiche nei corpi idrici e nel
suolo.
Land Use and Land Cover Change Detection Using Remote Geospatial Techniques: A Case Study of an Urban City in Southwestern, Nigeria
Authors: Olayungbo Adenike
Published: November 2021

Many cities in developing countries are experiencing ecosystem modification and change. Today, about 10 million hectares of the world’s forest cover have been converted to other land uses. In Nigeria, there is an estimated increase of 8.75 million ha of cropland and decrease of about 1.71 million ha of forest cover between 1995 to 2020, indicating that Nigeria has been undergoing a wide range of land use and land cover changes. This paper analyses the changes in land use/cover in Ila Orangun, Southwestern, Nigeria from 1986 to 2018, with a view to providing adequate information on the pattern and trend of land use and land cover changes for proper monitoring and effective planning. The study utilized satellite images from Landsat 1986, 2002 and 2018. Remote sensing and Geographical Information System techniques as well as supervised image classification method were used to assess the magnitude of changes in the city over the study period. The results show that 26.36% of forest cover and 44.48% of waterbody were lost between the period of 1986 and 2018. There was a rapid increase in crop land by 365.7% and gradual increase in built-up areas by 103.85% at an annual rate of 3.25%. Forest was the only land cover type that recorded a constant reduction in areal extent. The study concluded that the changes in land use and land cover is a result of anthropogenic activities in the study area.
Weak fuzzy topology on vector spaces
Authors: Daraby Bayaz , Khosravi Nasibeh , Rahimi Asghar
Published: November 2021

In this paper, we study the concept of weak linear fuzzy topology on a fuzzy
topological vector space as a generalization of usual weak topology. We
prove that this fuzzy topology consists of all weakly lower semi-continuous
fuzzy sets on a given vector space when K (R or C) endowed with its usual
fuzzy topology. In the case that the fuzzy topology of K is different from
the usual fuzzy topology, we show that the weak fuzzy topology is not
equivalent with the fuzzy topology of weakly lower semi-continuous fuzzy
sets.
METHODOLOGICAL SUPPORT OF PROFESSIONAL DEVELOPMENT OF TEACHERS OF PRESCHOOL EDUCATION INSTITUTIONS: PSYCHOLOGICAL AND PEDAGOGICAL FOUNDATIONS
Authors: Kovalenko Olena , Lakhman Diana
Published: November 2021

With the help of encyclopedias, dictionaries, reference books the article reveals the definitive characteristics of such basic research concepts as: methodological assistance, methodological work and methodological support. Based on the development of psychological and pedagogical research, the concepts of methodological work and methodological support are analyzed and differentiated. The domestic regulatory documents are cited, which reflect the issues of methodological support for the teachers. The elaborations of the main directions and forms of methodical work with teachers (mass, group and individual) are presented, the classification of principles and functions of methodical support is given. The list of interactive forms of methodological support for preschool teachers and their impact on improving methodological support for teachers is outlined. The concept of the professional development of teachers, components of professional development, their essence and structure are highlighted, as well as ways of influencе of the methodological support on its improvement are outlined. The article, based on reputable modern researchers and practitioners, defines the directions, features and psychological and pedagogical conditions for providing methodological support for the professional development of teachers of preschool education institutions. The problems of implementing methodological support for teachers in preschool institutions are listed and analyzed, as well as prospects for improving its effectiveness are outlined.
TRADUCTION DES NOMS DES FILMS FRANÇAIS : ASPECT LINGUOCULTUREL
Authors: Kulykova Viktoriia
Published: November 2021

L’article proposé étudie les moyens de traduction en ukrainien des particularités linguistiques et culturologiques des noms des films français. En particulier, on détermine les caractéristiques lexicales et sémantiques des titres français et les voies de leur reproduction dans la langue cible à travers le prisme de l’approche culturologique. Les titres représentant une situation verbalement codée qui est modélisée par le film se concentrent sur l’attention particulière du spectateur. A cette fin, ils sont brillants, attirants, expressifs. Les fonctions principales des noms des films sont les suivantes: nominative, c’est-à-dire la présentation au spectateur de l’idée principale du film; informative, à savoir la transmission des informations principales; publicitaire, pour attirer le public; pronostique, c’est-à-dire l’addition des éléments associatifs; pragmatique, qui vise à influencer et à exciter les sentiments humains. Il a été constaté que les noms propres, les anglicismes, les chiffres, les onomatopées sonores sont largement utilisés dans les titres des films français. Lors de la traduction, on recourt à des moyens et à des transformations tels que: la traduction littérale, la translittération, la substitution lexico-sémantique, l’addition et l’omission des éléments.
LENGUAJE OFENSIVO Y SU TRADUCCIÓN EN LOS TEXTOS LITERARIOS
Authors: Volynets Nataliia
Published: November 2021

La traducción literaria es un verdadero "arte verbal" (Vinogradov, 1978), que requiere del traductor las habilidades adecuadas y un profundo conocimiento enciclopédico para reproducir y transmitir la esencia ideológica de la obra original. Gracias a la traducción literaria las cultura se enriquecen y se complementan una a otra. En la lieratura moderna española y latinoamericana se utiliza cada vez más el lenguaje ofensivo, cuya reproducción adecuada en otro idioma es uno de los problemas actuales de los estudios de traducción. Normalmente, los autores utilizan el lenguaje soez para el discurso vivo de los personajes, la creación de un cierto efecto emocional, la imagen de los personajes. La reproducción de las unidades comunicativas de este campo léxico-semántico en las traducciones provoca ciertas dificultades, por su contenido semántico-denotativo que no coincide en diferentes idiomas. Por tanto, el traductor debe buscar un equivalente funcional que pueda reproducir de forma natural el lenguaje malsonante, sin suavizarlo ni reforzarlo, y transmitir el efecto que el autor ha creado en su obra. El artículo presenta interpretaciones modernas del concepto del lenguaje soez o malsonante, también describe los problemas y métodos de traducción de este vocabulario al ucraniano.
THE PHENOMENON OF PLAY IN THE CONTEXT OF THEATRICAL AND STAGE ART: TO THE PROBLEM OF UNDERSTANDING
Authors: Shaobo Huang
Published: November 2021

The article analyzes the main approaches to the study of the phenomenon of play, highlighting the key research positions on the way to identify the essence of this phenomenon. In most studies, the phenomenon of play is considered as a cultural universal and the main source of human cultural activity. In this regard, the main aim of this article is to consider the phenomenon of play as a necessary component of musical art, highlighting the importance of play logic in musical and stage genres. Consequently, the triad of the concepts of play – composition – motor ability, forms a single conceptual field, which contributes to the identification of the features of the ways of formation of music. Moreover, in this triad, it is the third component – motor ability – that appears as the first manifestation of the play purpose of the artistic form, which in turn is a manifestation of the inner drama and psychological subtext of the composition, which correlates it with stage and theatrical action, the phenomenon of theatricality, which acquires special relevance in musical art in general, and opera forms in particular.
ISSUES OF DETERMINING THE CONTEXT OF RESTRICTED INFORMATION SECURITY
Authors: Kots Dmytro , Kudrytskyi Maksym , Dolia Valentyna
Published: November 2021

The article analyzes the problematic issues of determining the content of the concept of protection of restricted information, in particular, the authors analyze the existing terminology used by the legislation of Ukraine on the protection of restricted information. The authors of the article, based on existing legislation regulating such information storage measures as information protection, technical protection of information, cryptographic protection of information, cyber protection, using the deductive method of research derived the definition of “protection of restricted information”. In addition, using various scientific research methods, the authors of the article highlight the issues of legal uncertainty and contradictions in the concepts of some types of restricted information protection, which are found in the guidance documents on the subject of research. Also, in the article: the properties of information are derived and the types of operations with information are determined. This took into account the understanding of the concept of “restricted information”, which was defined by one of the authors in his previous work; the idea of the content of protection of restricted information is summarized, and also each of properties of the information which make the content of its protection is investigated.
INTERNATIONAL STANDARDS REGULATING LABOUR OF UNDERAGE WORKERS
Authors: Sydorenko Anna , Polkhovska Inna
Published: November 2021

The paper presents an analysis of the international standards governing child labour. It is determined that the right to work is every able-bodied person’s inalienable and indispensable right. Under current conditions of social development, the issues of legal regulation of labour of specific categories of workers are becoming of vital importance. It is proved that their regulation is based on differentiation which is defined by the extension of children rights. It is researched that in legislation of most countries, regulation of child labour is allocated in a separate institute whose rules, to a greater extent, correspond to international standards. It is determined that all countries should take measures to protect children’s rights and freedoms in the exercise of their right to work. It is proved that the acts of the European Union contain a specified list of children’s rights which should be the basis for developing and enhancing national labour legislation. It is determined that labour law, as well as any field of law, is distinguish by unity and differentiation. Unity is characterized by spreading labour law rules for all workers without exception, and differentiation of legal regulation of labour is characterized by the specification of the rules governing labour of specific categories of workers. It is investigated that differentiation of child labour is based on a subjective feature and is determined by the age, physiological, psychological and social factors. It is determined that differentiation of labour of this category of workers implies providing them with additional social and labour guarantees, as well as the use of restrictions and prohibitions when performing certain types of work. It was researched that the main criterion for child labour is differentiation of their age and working conditions. Their basic requirements are established by international rules and implemented in the national legislation.
PHYSICAL THERAPY FOR EMERGENCY ABDOMINAL SURGERY: STATE OF THE PROBLEM IN UKRAINE
Authors: Hula Hanna , Bas Olha
Published: November 2021

For today there are significant medical advances in surgical treatment of emergency abdominal pathology and surgical techniques. However, the place of physical therapy in guidelines of acute abdominal pathology complex treatment remains insufficiently described in the specialized literature, and its significance in clinical practice underestimated. Emergency abdominal surgical pathology still remains a significant proportion of all surgical diseases, whereas mortality and postoperative complications remain considerably high. Surgical interventions in this cohort belong to the high-risk category in the cases of old age, poor general health with the limited cardiorespiratory reserve, low physical strength and obesity. Among other reasons of this study importance, there are insufficient clinical guidelines and misunderstanding of physical therapy impact on treatment outcome, such as mortality, frequency and type of postoperative morbidity, duration of in hospital stay, quality of life and rate of physical recovery. Only moderate quantity of thorough studies is available, concerning major urgent abdominal pathology complex treatment which comprehends surgical, anesthesia, laboratory, imaging, physiotherapy and nutritional support expertise. However, current evidence from trials remains obscure due to absence of clearly defined, standardized physiotherapy interventions, which limits the comparison in the treatment outcomes assessment. Currently in Ukraine there are no standards of physical therapy in clinical protocol of emergency abdominal surgical pathology. Consequently, there is a necessity for theoretic and practical justification of physical therapy as an important component of comprehensive treatment in the case of emergency abdominal surgical pathology.
Life Skill Profile of Residents Learning Package C at PKBM Serang District and Its Implications for the Guidance and Counseling Program (Research A Descriptive Study on Residents Learning Package C in PKBM Serang Distrsict in the Academic Year 2021-2022)
Authors: Dalimunthe Raudah Zaimah
Published: November 2021

This research aims at describing the illustration of life skill level in thelearning community and discovering the design of the Guidance and Counseling Program to improve life skill on Residents Learning Package C at PKBM Serang District, Indonesia. The survey takes census samples which amounts to 86 learning Residents. The life skill scale was carried out by looking at four aspects, namely personal skills, academic skills, social skills, and vocational skills.Data analysis is performed by descriptive quantitative technique. The result of the questionnaire analysis on the life skills level on Residents Learning Package C atPKBM in Serang District were in low category with a percentage of 20%, the medium category with a percentage of 68%, and the high category with a percentage of 12%. After discovering the description of the life skill level, the design of the Guidance and Counseling Program was made based on the research results obtained.
The Effectiveness of Behavioral Counseling with Modeling Techniques to Improve Student Self-Achievement
Authors: Dharsana I Ketut , Paramartha Wayan Eka
Published: November 2021

This study aims to determine the difference between before and after treatment and to determine the effect of behavioral counseling with modeling techniques to improve student self-achievement. The research was conducted at SMK Negeri 1 Singaraja in class X, and used a randomized controlled trial (RCT) research design. Sampling in this study through simple random sampling which took 2 research samples, namely the experimental and control classes. The results of this study indicate the influence of behavioral counseling with modeling techniques to increase self-achievement through the effect size test. Based on these results, the researcher recommends behavioral counseling with modeling techniques to increase self-achievement in school.