bluuebunny/crossref_metadata_2025 huggingface dataset:
FANDOM NATION: IDENTIFYING THE SELF-WORTH OF STUDENT INFLUENCERS OF PHILIPPINE SCHOOL DOHA, A PHENOMENOLOGY
Authors:   Philippine School Doha, Doha, Qatar., M. Edrosolam Julius , Laurena Denisse Luceno ,   Research Development, Accreditation and Publication Office, PSD, Doha, Qatar., Guzman Aaron Christian De ,   Research Capstone Project, PSD, Doha, Qatar., Ian Ezekhiel Vital ,   Philippine School Doha, Doha, Qatar., Edward Arbo ,   Research Capstone Project, PSD, Doha, Qatar., Nathaniel Jush Arcobillas ,   Research Development, Accreditation and Publication Office, PSD, Doha, Qatar., Abdul Aziz Abutazil ,   Philippine School Doha, Doha, Qatar.
Published: March 2021

Background: The study encourages important and essential information gathered from members who are comparative with the actual presentation. Self-identity is the motivation behind this investigation conceptualizes how being a fan recognizes the actual researchers. Distinguishing self-worth in an instruction encompassing is fundamental. Students should be engaged to prepare their entitlement to articulation following their creating limit building self-esteem and procure information and abilities required for contest reason, dynamic, correspondence, and life challenges. Methods: The Qualitative type of research design applied, which utilizes responses inquiring concerning experiences from the participants viewpoint. Findings: This study examines how self-worth affects student influencers by fandom online and offline communities. Which leads to our central question, What are the benefits of social media in identity for the self-worth of selected PSD influencers? The main themes were: Fame and Fortune, Influence, Genuine Enthusiasts, and Entertainment. Fame and Fortune is the idea that manages cooperation and openness of the student influencers subsequently, it is a condition known while Fortune relates to abundance. Influence has an impact and can muchly affect the impression of others on somebody. Influence can be seen anyplace, either in web-based media or anyplace in PSD. The individuals who have a sizable measure of Influence are called influencers. Influencers might be the scaffold to discovering somebodys worth or the other way around, as found in one of the numerous reactions which express. Genuine Enthusiasts allude to the motivation to fulfill such prerequisites and become more grounded the more expanded the range they are denied. Ultimately, Entertainment gives euphoria and fervor to the watchers. Conclusions: Students can struggle to find their self-worth because of the steady difference in their environmental factors. Students in Philippine School Doha are presented to various types of individuals affected by their activities, giving them trouble finding their self-worth in a school loaded with multiple understudies. Recommendations: The data and observations found in this study could show a more concrete answer if it utilized a more significant response. Analyze and identify the behavior in a more detailed and intricate way from which a more paradigm can form.
RECENT ADVANCES ON GINGIVAL TISSUE MANAGEMENT IN RESTORATIVE DENTISTRY
Authors:   Professor Department of Conservative Dentistry and Endodontics, Yenepoya Dental College, Yenepoya University, Deralakatte 575018- Mangalore, Karnataka., Shetty S Vidhyadhara , Kauser Munaff Madeha ,   Post Graduate student Department of Conservative Dentistry and Endodontics, Yenepoya Dental College, Yenepoya University, Deralakatte 575018- Mangalore, Karnataka., M.S Prathap ,   Head of the department of Conservative Dentistry and Endodontics, Yenepoya Dental College, Yenepoya University, Deralakatte 575018- Mangalore, Karnataka.
Published: March 2021

Marginal integrity is one of the main factors that contribute to the outcome of a restoration and longevity of the restoration and cast restorations. An increased significance on the perioâ€“restorative interface in restorative dentistry is essential to enable the utilization of the concept of biologic width in a practical manner. The goal, regarding the management of gingival tissues, is to ensure that the peridontium is in a healthy state. The oral cavity is a difficult to treat because of lips, cheeks, and tongue that hinders and makes it difficult to visualize and manipulate instruments in the area to be treated related. Gingival retraction is essential to perform better when the finish lines of the restoration is below the gingival margin. There are various gingival retractions that have been employed previously like mechanical, chemical, surgical and chemomechanical procedures. These methods not only provide an ideal working environment and ample vision, but also maintain hemostasis to certain extent. The choice of a retraction method depends on clinical situation and accessibility. The purpose of this review is to demonstrate the recent retraction materials and techniques.
ANALYSIS OF THE CONTRIBUTION OF INFORMATION TECHNOLOGY IN INVESTMENTS
Authors:   BA LLB(h) Amity Law School., Philip V Mathews
Published: March 2021

This research paper is made with the view of analyzing the contributions of technology in investment sector. Furthermore it tries to answer the big questions like whether technology help to get higher returns from the investments in the stock market? or what is next in investing? or what is the role of technology in investment banking?.
THE EFFECTS OF MUSIC ON STRESS
Authors:   Currently Unaffiliated, Kolkata, India., Chaudhuri Soma
Published: March 2021

At the most basic level, stress is our bodys response to pressures from a situation or lifes event. Although in short occurrence or at optimum level stress may be considered to have positive effects, excess and prolonged stress can cause physiological as well as psychological health disorders. Stress cannot be avoided or omitted, but one can reduce or manage the level of stress using several relaxation techniques. Through age-long research, listening to music has been proven to be a powerful tool for stress reduction. Music has been reported to have direct effects on nervous system, immunological and endocrine system of the human body. Amongst various neuroimaging techniques,electroencephalogram(EEG) is a useful electrophysiological biomarker to monitor the neuronal activities of the human brain with high temporal resolution. In research setting EEG signals are used in mental stress study. The present article attempts to review scientific literature in support of the pivotal role of music on stress reduction. Discussions on stress and its effects on human health are followed by the quantification of stress by EEG for identification and classification of stress. The role of music on stress reduction has been discussed with a light on musical neurofeedback as an effective measure for stress reduction. This comprehensive review would provide theoretical support for claims that music would act as stimuli for stress characterization and also would have its ability to serve as effective and potential measure for stress reduction in everyday life.
IMPACT OF COVID-19 PANDEMIC ON ANXIETY AND OBSESSION LEVEL OF THE UNIVERSITY STUDENTS AND ITS RELATION TO THEIR ACADEMIC PERFORMANCE
Authors:   Research Scholar, Department of Educational Studies, Faculty of Education, Jamia Millia Islamia, New Delhi, India., a Vandana , Saleem Nudrat ,   Research Scholar, Department of Educational Studies, Faculty of Education, Jamia Millia Islamia, New Delhi, India.
Published: March 2021

With the spread of COVID-19 pandemic, concerns related to panic and increasing anxiety have been multiplying by each passing day. Consequently, schools, colleges, educational institutions, and workplaces have been shut since mid of March, 2020 in India. This study attempted to find the psychological repercussions on academic performance of university students while focusing upon finding the anxiety and obsession level related to COVID-19. The study exhibited the correlation between anxiety and academic performance of university students and between the level of obsession and academic performance related to coronavirus among university students of India. 157 students from the age group of 17-25 years enrolled to undergraduate and postgraduate courses participated in the study. Snowball sampling technique was used to reach students through online mode. Two tools, namely, CAS (Coronavirus Anxiety Scale) and OCS (Obsession with COVID-19 Scale) developed by Prof. Sherman Lee with the team of psychologists from the Christopher Newport University were adapted for the presented study by further adding a dimension of academic performance in the tool. The results revealed that 10.8% students were highly anxious and 28% students were highly obsessed with the coronavirus and have developed disturbed thinking patterns. The correlation between anxiety and academic performance of students as well as between obsession and academic performance of students were found to be statistically significant (p â‰¤ .001) with a moderate level of correlation. Overall, the study found that the outbreak of coronavirus has impacted the psychological health as well as the academic performance of university students in India.
ROLE OF CIRCULAR RNAS IN TUMORIGENESIS AND THEIR POSSIBLE APPLICATIONS IN CANCER DIAGNOSIS AND TREATMENT
Authors:   Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University,Badr,Cairo-Suez Road 11829, Cairo, Egypt., Samy Awad M. , Elagawy Waleed ,   Department of Tropical Medicine, Faculty of Medicine, Portsaid University, Egypt., Al-Sawaf H.A. ,   Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University,Badr,Cairo-Suez Road 11829, Cairo, Egypt., Taha Heba ,   Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, 11795, Ain Helwan, Cairo, Egypt., Zaky El Sharkawi Fathia ,   Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, 11795, Ain Helwan, Cairo, Egypt.
Published: March 2021

Circular RNAs (circRNAs) play critical roles in the development and progression of diseases, especially in cancer. Thus, expanding our understanding of circRNAs will enrich knowledge of cancer and give new opportunities for cancer therapy. In this review, we discuss the genesis of circular RNAs, their types and epigenetic aspects in tumorigenesis of abnormal cellular proliferation. The possible applications of individual circRNAs as biological markers in laboratory diagnosis of cancer received considerable attention recently.
FEATURES OF THE COMPARISON OF UZBEK AND KOREAN LANGUAGES AND THE PROCESS OF EXPANDING THE MEANING OF COMPARISON EXPRESSIONS
Authors:   Independent Researcher,Tashkent State University of Oriental Studies,Uzbekistan., Min Young Jo
Published: March 2021

This article will explore in detail the concept between Uzbek and Korean, the characteristics of comparisons, which are representative types of figurative expression, and the process of expanding the vocabulary meaning of words to the meanings of comparisons. Figurative expression means a deviation from the laws of everyday language and it shows the appearance of a connection between the dictionary meaning and the metaphorical meaning of words based on their forms or similarities of attributes. In particular, this article will examine the meaning of comparisons defined in the Uzbek and Korean languages ÃƒÂƒÃ‚Â¢ÃƒÂ‚Ã‚Â€ÃƒÂ‚Ã‚Â‹ÃƒÂƒÃ‚Â¢ÃƒÂ‚Ã‚Â€ÃƒÂ‚Ã‚Â‹and the type of words connecting comparisons used when expressing comparisons, which will be confirmed by examples of comparisons in Uzbek and Korean. In addition, with the help of examples, it will be possible to find out that, unlike comparative connecting words in the Uzbek language, in Korean, comparative connecting words in a sentence, depending on the part of speech, can be interchanged, but there may be cases where they cannot be replaced. Comparative compounds in the Uzbek language can be interchanged without limitation. Also, with the help of examples, the phenomenon of vocabulary expansion of words when used in comparative phrases in Korean will be explained in detail.
ADOPTION OF SELECTED DRUDGERY REDUCTION TECHNOLOGIES RELATED TO AGRICULTURE BY THE FARM WOMEN
Authors:   Scientist, KVK, JAU Amreli Gujarat., Tiwari Neha , N. Vyas Jiju ,   Associate Professor SDAU Dantiwada Gujarat.
Published: March 2021

The present study was conducted in Gonda district of Uttar Prades. The purpose of the study was to know the adoption of selected drudgery reduction technologies related to agriculture by the farm women. The 100 farm women were randomly selected for technological empowerment through training from two purposively selected panchayat samities. Personal interview technique was used for collecting data. The findings of the study reveal that manual bund former, serrated sickle and maize sheller were the main technologies used by majority of the respondents as indicated by higher adoption index (60%). This may be due to reason that the technologies were easy to use and handle, cheap in cost, require less effort while operation as compared to traditional methods. Wheel hoe, manual seed drill and knapsack sprayer were the other technologies adopted by more than half of the respondents with adoption index 47.5- 50 per cent followed by manual rice transplanter and ground nut decorticator with adoption index 35-43 percent.
COMPARISON AND EVALUATION OF TACROLIMUS VS STEROID THERAPY IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE IN ACTIVE PHASE
Authors:   Student of Doctor of Pharmacy (Pharm D), Deccan School of Pharmacy, India., Samreen Zeba , Sultana Minhaj ,   Student of Doctor of Pharmacy (Pharm D), Deccan School of Pharmacy, India., Shanawazuddin Mohd ,   Student of Doctor of Pharmacy (Pharm D), Deccan School of Pharmacy, India., Zainab Tahoora ,   Student of Doctor of Pharmacy (Pharm D), Deccan School of Pharmacy, India., Ibrahim Hassan Syed ,   Dept. of Gastroenterology Princess Esra Hospital, Hyderabad, India., Mohiuddin Mohammed ,   Dept. of Pharmacology at Deccan School of Pharmacy, Hyderabad, India., Ahmed Khan Aleem ,   Central Research Lab, OHRC, Princess Esra Hospital, Hyderabad, India.
Published: March 2021

Background:-The aim of the study is to compare and evaluate the efficacy and safety of short-term outcomes of tacrolimus in inflammatory bowel disease (IBD) patients who were not concomitantly receiving other immunosuppressive therapies by carrying out an observational prospective study of tacrolimus (TAC) v/s corticosteroid (CS) therapy in the treatment of IBD in active phase, to prevent patient from long term use of CS by reducing the incidence rate of flare. To use TAC as a step-up approach in IBD by early induction of remission and maintain it for longer period which reduces re-hospitalization and surgery rate hence improving quality of life. Method And Material:-The study was conducted in gastroenterology department, Princess Esra hospital, Hyd. 50 patients were enrolled based on our inclusion and exclusion criteria, allocated in 2 groups receiving CS and TAC respectively for 10 days. Follow-ups were done and at the end of 2 months, again a colonoscopy was performed to assess the effectiveness of the treatment. Results:-At an initial therapy of 2 months, clinical remissions were observed in most of the patients of both the groups. After six months of treatment, TAC showed 100% remission rate while 20% patients on CS have shown flare. Conclusion:- prolongs period of remission, and prevents the long-term use of CS thereby preventing its complications proving step-up to be a better approach towards the management of IBD. This study concludes that the efficacy and safety profile of TAC was overall favorable, and the doses were well tolerated by most of the patients.
FRONTONASAL EPIDERMOID CYST WITH PATENT DERMAL SINUS TRACT OPENING ON THE DORSUM OF NOSE AND INTRACRANIAL EXTENSION THROUGH CRIBRIFORM PLATE DEFECT: A RARE CASE REPORT WITH REVIEW OF LITERATURE
Authors: Sharma Akshay , Chauhan Narvir , Pandoh Pranav , Sharma Deeksha
Published: March 2021

Congenital midface anomalies are rare. Multiple congenital midface anomalies occur in children. Imaging techniques like computed tomography (CT) and magnetic resonance imaging (MRI) help in characterising the lesions, making definite diagnosis and knowing about intracranial extension. We present a case report of 8 year old female child with Frontonasal Epidermoid Cyst with patent dermal sinus tract opening on the dorsum of nose and intracranial extension through cribriform plate defect.
MOBILE PHONE USAGE PATTERN AMONG YOUTH IN THE URBAN AND RURAL AREA
Authors:   Department of Economics, M.J.P.R. University., Maheshwari Udit
Published: March 2021

In the current scenario, the mobile phones have become an integral part of our life and its usage increased rapidly, many of the peoples overusing it without clear understanding of their usage time. India is the 2nd largest country according to internet use Mobile phones is also important from economic perspective to a country as its sale contributes significantly to Gross Domestic Product globally 4.4% and domestically 6.5%. The study aims to investigate the usage pattern of the mobile phone especially among youth and factors affecting their buying behaviour toward mobile phones. Primary Data has been collected from 106 respondents from the Bareilly and Kasganj districts in Uttar Pradesh, India by using both the online method and field survey. Qualitative data has also been collected from the different mobile phone sellers. The results indicated that most people use their phone for entertainment purpose the most (39.6%) while least for social media (9.4%) and the factors that affect buying the most internet(40.6%) while least valuable factor is the convenience of calling(8.5%).
RISPERIDONE INDUCED LEUCOPENIA AND NEUTROPENIA: A CASE REPORT AND BRIEF REVIEW OF LITERATURE
Authors:   Department of Psychiatry, IBN NAFIS Hospital, Mohammed VI University Hospita Marrakech, Morocco., Berghalout M. , Ait Idar A. ,   Department of Psychiatry, IBN NAFIS Hospital, Mohammed VI University Hospita Marrakech, Morocco., Guennouni H. ,   Department of Psychiatry, IBN NAFIS Hospital, Mohammed VI University Hospita Marrakech, Morocco., Ouazzani K.El ,   Department of Psychiatry, IBN NAFIS Hospital, Mohammed VI University Hospita Marrakech, Morocco., Adali I. ,   Department of Psychiatry, IBN NAFIS Hospital, Mohammed VI University Hospita Marrakech, Morocco., Manoudi F. ,   Department of Psychiatry, IBN NAFIS Hospital, Mohammed VI University Hospita Marrakech, Morocco.
Published: March 2021

Hematological abnormalities are frequently encountered during treatment with antipsychotic drugs. Most of these are mild and of no clinical significance, but in a small minority of patients, hazardous, potentially life-threatening hematological effects, including leucopenia, neutropenia, agranulocytosis, thrombocytopenia, anaemia , leucocytosis, thrombocytosis, eosinophilia and altered platelet function. (1). Clozapine is associated with several well-known abnormalities of blood cell count (2), but some case reports associate novel antipsychotics, such as risperidone with leucopenia and agranulocytosis (3). This report describes a case of leucopenia under treatment with Oral Risperidone , suggesting the necessity of early recognition of leucopenia in order to prevent occurrence of potentially life-threatening agranulocytosis. ( 1) .
Linking climate change to soil loss estimation in the Kosi river basin, India
Authors: Towheed Aadil , Roshni Thendiyath
Published: March 2021

This study assessed the spatio-temporal variability of soil loss based on rainfall–runoff erosivity in the context of climate change in the Kosi river basin. The observed rainfall data (1985–2017) were used for past and present analyses, and the projected rainfall data (2020–2100) interpolated for various general circulation models (GCMs) were used for future analysis. The results of rainfall analysis for the projected period show a maximum percentage variation of 26.2% for a particular GCM and an average of 9.4% increase in the rainfall data from all selected GCMs considering three representative concentration pathways (RCPs). We also evaluated the implications of change in the soil loss due to changes in the rainfall pattern and crop management factor for three time slices. The results for the projected time period showed a concomitant increase in the average soil loss of −13.03–10.39% with respect to the baseline. The average soil loss results for the time period of 2020–2100 are also compared with the average soil loss for each RCP scenario and found very meager changes in the area of soil erosion. The results due to climate change aid in prioritizing the areas with suitable conservation support practices.
A comparative study of wavelet and empirical mode decomposition-based GPR models for river discharge relationship modeling at consecutive hydrometric stations
Authors: Roushangar Kiyoumars , Chamani Masoumeh , Ghasempour Roghayeh , Azamathulla Hazi Mohammad , Alizadeh Farhad
Published: March 2021

The river stage–discharge relationship has an important impact on modeling, planning, and management of river basins and water resources. In this study, the capability of the Gaussian Process Regressions (GPR) kernel-based approach was assessed in predicting the daily river stage–discharge (RSD) relationship. Three successive hydrometric stations of the Housatonic River were considered, and based on the flow characteristics during the period of 2002–2006 several models were developed and tested via GPR. To enhance the applied model efficiency, two pre-processing techniques, namely Wavelet Transform (WT) and Ensemble Empirical Mode Decomposition (EEMD), were used. Also, two states of the RSD modeling were investigated. In state 1, each station's own data was used and in state 2, the upstream stations’ datasets were used as input to model the RSD downstream of the river. The single and integrated model results showed that the integrated WT- and EEMD-GPR models resulted in more accurate outcomes. Data processing enhanced the models' capability between 25% and 40%. The results showed that the RSD modeling in state 1 led to better results; however, when the station's own data were not available the integrated methods could be applied successfully for the RSD modeling using the previous stations’ data.
MicroRNAs: A Critical Regulator and a Promising Therapeutic and Diagnostic Molecule for Diabetic Cardiomyopathy
Authors: Mathur Priyanka , Rani Vibha
Published: March 2021

The risk of heart failure is 2-5 times higher in diabetic patients as compared to non-diabetic
patients with similar comorbidities. Recent reports suggest that nearly half of the diabetic population
remains undiagnosed, making diabetic cardiomyopathy (DCM) a clinically relevant entity.
In the myocardium, chronic hyperglycemia elicits structural and functional abnormalities characterized
by ventricular dilation, diastolic dysfunction, fibrosis, and hypertrophy leading to heart failure.
Since diabetes is a multifactorial heterogeneous metabolic disorder which cannot be diagnosed or
controlled along with coronary artery disease or hypertension, there is an urgent need to understand
the underlying molecular mechanisms that leads to DCM and identify potential therapeutic targets.
Small non-coding RNAs, in particular, microRNAs (miRNAs), have emerged as key regulators for
several life-threatening diseases, including DCM. Recent studies have reported that miRNAs not
only regulate the fundamental mechanisms of DCM such as insulin resistance, MAPK pathway,
PI3K-AkT pathway, oxidative stress, also inflammatory signaling, but also possess the potential to
be a therapeutic or diagnostic target. This review examines the role of critical miRNAs in the onset
and pathogenesis of DCM, which also depicts high potential as therapeutic and diagnostic
molecule in preclinical studies. Further, it highlights the completed and on-going clinical trials
around the globe for diabetes and miRNAs to provide a outlook about the upcoming miRNA therapeutics.
Seco-Tetracyclic and Seco-Pentacyclic Triterpenoids from Nature: Phytochemistry,
Biological Activity: A Review
Authors: Liu Yingkai , Jian Yuqing , Cao Mengru , Wang Bin , Qiu Yixing , Yuan Hanwen , Zhou Xudong , Li Bin , Sheng Wenbing , Peng Caiyun , Zhang Zaiqi , Wang Wei
Published: March 2021

:

Seco-tetracyclic and seco-pentacyclic triterpenoids are a special class of triterpenoids with
ring/rings cleaved on the original skeleton structures. A class of important triterpene derivatives, secotetracyclic
and seco-pentacyclic triterpenoids, have long stimulated the interest and attention of botanists
and natural products chemists. There is no systematic and comprehensive review for them. This
review is focused on the phytochemical investigations and biological activities of seco-tetracyclic and
seco-pentacyclic triterpenoids from nature, covering the literature from 2000-2019. This review describes
310 seco-tetracyclic and 139 seco-pentacyclic triterpenoids discovered from 154 species belong
to 97 genera, which cover the chemical structures, types, sources, and bioactivities of compounds.
The literature from 2000-2019 is reviewed and 208 references are cited.
Pseudothrombocytosis in Case of Betathalassaemia Intermedia Masquerading as Myeloproliferative Neoplasm
Authors: Purohit Abhishek H.L. , Bharti Sushma , Kumar Deepak , Bohra Gopal Krishana , Khichar Satyendra
Published: March 2021

Finding spurious thrombocytopenia is a common occurrence in clinical practice,
whereas pseudothrombocytosis is a very uncommon event. Despite several technical advancements
in automated haematology analysers, a careful peripheral smear examination remains standard examination
in cases of discrepancy of platelet counts. We are presenting a case of betathalassaemia
intermedia who had pseudothrombocytosis, which was falsely labelled as myeloproliferative neoplasm
before the patient visited our haematology clinic.
Use of Gadoxetic Acid-enhanced MRI to Predict the Development of Postoperative Pancreatic Fistulas by Estimating the Degree of Pancreatic Fibrosis
Authors: Yunaiyama Daisuke , Saito Kazuhiro , Yamaguchi Hiroshi , Nagakawa Yuichi , Harada Taiyo Leopoldo , Nagao Toshitaka
Published: March 2021

Background:

Post-operative pancreatic fistula (POPF) can be life-threatening, and gadoxetic
acid-enhanced MRI is routinely performed in patients undergoing pancreatic surgery. However,
previous reports have not investigated if gadoxetic acid-enhanced MRI can be used to predict
POPF risk.

Objective:

This study aims to explore if gadoxetic acid-enhanced MRI can predict pancreatic fibrosis
and the need for POPF treatment before surgery.

Methods:

We retrospectively analyzed gadoxetic acid-enhanced MR images from 142 patients
who underwent pancreatic surgery between January 1, 2011, and April 30, 2018. Pre-dynamic signal
intensity (SI) and values for the portal, transitional, and hepatobiliary phase standardized based
on pre-dynamic study values were analyzed. The diameter of the main pancreatic duct (DMPD)
was measured, and the degree of pancreatic fibrosis was classified as F0 – F3. We defined POPF
higher than grade B as significant.

Results:

Odds ratios for combinations that led to any degree of fibrosis higher than grade B were
defined as significant risk factors. The highest odds ratio was obtained for F0 vs. F1 – F3 (p =
0.038). DMPD (p < 0.001), pre-SI (p = 0.008), portal-SI/pre-SI (p < 0.001), transitional-SI/pre-SI
(p < 0.001), and hepatobiliary-SI/pre-SI (p = 0.012) were significantly correlated with the presence
of fibrosis. Moreover, the presence of fibrosis was best detected by DMPD (AUC = 0.777). Individual
specificity values of transitional-SI/pre-SI and DMPD were 95.5% and 86.6%, respectively,
and their combined specificity was 97.7%.

Conclusion:

The absence of pancreatic fibrosis is a risk factor for developing POPF higher than
grade B. DMPD was the most useful diagnostic indicator for the presence of fibrosis among our
analysis, and its specificity increased when combined with transitional-SI/pre-SI.
A Novel 4H-Chromen-4-One Derivative from Marine Streptomyces ovatisporus
S4702T as Potential Antibacterial and Anti-Cancer Agent
Authors: Kurt-Kızıldoğan Aslıhan , Akarsu Neslihan , Otur Çiğdem , Kivrak Arif , Aslan-Ertas Nevroz , Arslan Sevki , Mutlu Dogukan , Konus Metin , Yılmaz Can , Cetin Dogan , Topal Tufan , Şahin Nevzat
Published: March 2021

Background:

Marine actinomycetes are among indispensable sources of natural bioactive compounds
with unique antimicrobial and anti-cancer activities.

Objective:

Herein, it was aimed to elucidate the bioactive potential of a marine-derived Streptomyces ovatisporus
S4702T, isolated previously.

Methods:

Streptomyces ovatisporus S4702T was cultured in N-Z Amine broth, and extraction was carried out
using different organic solvents. Bioassay-guided purification was followed by chemical characterization using
NMR and LC-MS/MS. The compound was then evaluated for its antibacterial, antioxidant and cytotoxic
activities.

Results:

Etyl acetate extracts gave the highest antibacterial activity, and chemical characterization of this extract
indicated the formula as C15H29O5N3 and the corresponding possible molecular structure as 4H-chromen-4-one
derivative. It was found highly potent against Bacillus subtilis ATCC 6633 (MIC: 0.25 μg ml-1) and Micrococcus
luteus ATCC 9341 (MBC: 0.5 μg ml-1). It has no remarkable antioxidant activity, but a higher EC50 value and
less cytotoxicity against normal cells. The EC50 values of this chromen derivative were found as 9.68 μg ml-1 for
human colon carcinoma, 9.93 μg ml-1 for human prostate adenocarcinoma and 25.5 μg ml-1 for human embryonic
kidney cells.

Conclusion:

Overall, the presented 4H-chromen-4-one derivative is a remarkable bioactive compound with
potent antibacterial and cytotoxic activity. With its high bioactive potential, it is proposed as a good candidate in
medicine.
Synthesis and characterisation of biocapsules containing low-cost rejuvenators for asphalt self-healing
Authors: Concha Fuentealba Jose L. , Arteaga-Pérez Luis , Gonzalez-Torre Irene , Norambuena-Contreras Jose
Published: March 2021

This study aimed to characterise polynuclear biocapsules containing low-cost rejuvenating agents for asphalt self-healing. Capsules consisted of a biopolymeric matrix of calcium alginate containing cooking oil and mineral oil as rejuvenating agents, being synthesised using ionic gelation through the pumping dripping technique. The physical-chemical properties of the oil-in-biopolymer emulsions and their stability over time were studied. The morphological and thermophysical properties of the biocapsules, as well as the encapsulation efficiency of the rejuvenating agents, were quantified and characterised by microscopic techniques and laboratory tests. Main results showed that emulsions should be used for encapsulation purposes within a period no longer than 3h, reducing the effect of instability phenomena. Besides, the biopolymer-based polynuclear capsules presented uniform size, internal multicavity microstructure resulting in high encapsulation efficiencies and thermal stability at high temperatures, proving that cooking oil and mineral oil can be potentially used as low-cost rejuvenating agents and thermally stable additives for asphalt self-healing purposes.
Underrepresentation of Phenotypic Variability of 16p13.11 Microduplication Syndrome Assessed With an Online Self-Phenotyping Tool (Phenotypr): Cohort Study
Authors: Li Jianqiao , Hojlo Margaret A , Chennuri Sampath , Gujral Nitin , Paterson Heather L , Shefchek Kent A , Genetti Casie A , Cohn Emily L , Sewalk Kara C , Garvey Emily A , Buttermore Elizabeth D , Anderson Nickesha C , Beggs Alan H , Agrawal Pankaj B , Brownstein John S , Haendel Melissa A , Holm Ingrid A , Gonzalez-Heydrich Joseph , Brownstein Catherine A
Published: March 2021

Background

16p13.11 microduplication syndrome has a variable presentation and is characterized primarily by neurodevelopmental and physical phenotypes resulting from copy number variation at chromosome 16p13.11. Given its variability, there may be features that have not yet been reported. The goal of this study was to use a patient “self-phenotyping” survey to collect data directly from patients to further characterize the phenotypes of 16p13.11 microduplication syndrome.

Objective

This study aimed to (1) discover self-identified phenotypes in 16p13.11 microduplication syndrome that have been underrepresented in the scientific literature and (2) demonstrate that self-phenotyping tools are valuable sources of data for the medical and scientific communities.

Methods

As part of a large study to compare and evaluate patient self-phenotyping surveys, an online survey tool, Phenotypr, was developed for patients with rare disorders to self-report phenotypes. Participants with 16p13.11 microduplication syndrome were recruited through the Boston Children's Hospital 16p13.11 Registry. Either the caregiver, parent, or legal guardian of an affected child or the affected person (if aged 18 years or above) completed the survey. Results were securely transferred to a Research Electronic Data Capture database and aggregated for analysis.

Results

A total of 19 participants enrolled in the study. Notably, among the 19 participants, aggression and anxiety were mentioned by 3 (16%) and 4 (21%) participants, respectively, which is an increase over the numbers in previously published literature. Additionally, among the 19 participants, 3 (16%) had asthma and 2 (11%) had other immunological disorders, both of which have not been previously described in the syndrome.

Conclusions

Several phenotypes might be underrepresented in the previous 16p13.11 microduplication literature, and new possible phenotypes have been identified. Whenever possible, patients should continue to be referenced as a source of complete phenotyping data on their condition. Self-phenotyping may lead to a better understanding of the prevalence of phenotypes in genetic disorders and may identify previously unreported phenotypes.
A Smartphone App to Restore Optimal Weight (SPAROW) in Women With Recent Gestational Diabetes Mellitus: Randomized Controlled Trial
Authors: Lim Karen , Chan Shiao-Yng , Lim Su Lin , Tai Bee Choo , Tsai Cammy , Wong Su Ren , Ang Siew Min , Yew Tong Wei , Tai E Shyong , Yong Eu Leong
Published: March 2021

Background

Women with a history of gestational diabetes mellitus (GDM) are at an increased risk of developing type 2 diabetes mellitus (T2DM). Lifestyle interventions aimed at postpartum weight loss to reduce T2DM risk have been reported, but poor compliance remains a barrier. Smartphone-based interventions may improve compliance, but data on its use in women with recent GDM are limited.

Objective

This trial aimed to investigate the efficacy of a smartphone app in restoring optimal weight following delivery in women with GDM, in the setting of a population with high rates of GDM and type 2 diabetes.

Methods

In this unblinded randomized controlled trial, 200 women with GDM were randomized to receive the intervention or standard care following delivery. The intervention enabled logging of weight, meals, and activity, with web-based interaction with a team comprising dieticians, a physiotherapist, and an occupational therapist. The primary outcome was an achievement of optimal weight (defined as the restoration of first trimester weight if first trimester BMI≤23 kg/m2 or weight loss of at least 5% from first trimester weight if first trimester BMI>23 kg/m2) at 4 months post partum. Secondary outcome measures included absolute weight loss, serum metabolic markers, self-reported nutritional intake, health education, and quality of life via questionnaires and user engagement in the intervention group.

Results

In total, 40% (38/96) of women in the intervention group achieved optimal weight at 4 months post delivery compared with 32% (28/93) in the control group (P=.27). Compared with the control group, women in the intervention group reported significantly reduced caloric intake at 4 months after delivery (P<.001) and higher health-directed behavior scores (P=.045). The intervention group also reported increased emotional distress scores (P=.01). At 4 months, participant engagement with the intervention was maintained at 60.8% (SD 33.9%).

Conclusions

Although a statistically significant increase in women achieving healthy weight was not observed, this app remains promising, as women in the intervention group reported improved health behaviors and lower caloric intake. Importantly, the high retention rates suggest that a larger study with a longer follow-up period might confirm the effectiveness of this app for weight management.

Trial Registration

ClinicalTrials.gov NCT03324737; https://clinicaltrials.gov/ct2/show/NCT03324737

International Registered Report Identifier (IRRID)

RR2-10.1186/s12889-019-7691-3
A Web-Based Group Cognitive Behavioral Therapy Intervention for Symptoms of Anxiety and Depression Among University Students: Open-Label, Pragmatic Trial
Authors: Bantjes Jason , Kazdin Alan E , Cuijpers Pim , Breet Elsie , Dunn-Coetzee Munita , Davids Charl , Stein Dan J , Kessler Ronald C
Published: March 2021

Background

Anxiety and depression are common among university students, and university counseling centers are under pressure to develop effective, novel, and sustainable interventions that engage and retain students. Group interventions delivered via the internet could be a novel and effective way to promote student mental health.

Objective

We conducted a pragmatic open trial to investigate the uptake, retention, treatment response, and level of satisfaction with a remote group cognitive behavioral therapy intervention designed to reduce symptoms of anxiety and depression delivered on the web to university students during the COVID-19 pandemic.

Methods

Preintervention and postintervention self-reported data on anxiety and depression were collected using the Generalized Anxiety Disorder-7 and Patient Health Questionnaire-9. Satisfaction was assessed postintervention using the Client Satisfaction with Treatment Questionnaire.

Results

A total of 175 students were enrolled, 158 (90.3%) of whom initiated treatment. Among those initiating treatment, 86.1% (135/158) identified as female, and the mean age was 22.4 (SD 4.9) years. The mean number of sessions attended was 6.4 (SD 2.8) out of 10. Among participants with clinically significant symptoms at baseline, mean symptom scores decreased significantly for anxiety (t56=11.6; P<.001), depression (t61=7.8; P<.001), and composite anxiety and depression (t60=10.7; P<.001), with large effect sizes (d=1-1.5). Remission rates among participants with clinically significant baseline symptoms were 67.7%-78.9% and were not associated with baseline symptom severity. High overall levels of satisfaction with treatment were reported.

Conclusions

The results of this study serve as a proof of concept for the use of web-based group cognitive behavioral therapy to promote the mental health of university students.
A Smartphone App to Restore Optimal Weight (SPAROW) in Women With Recent Gestational Diabetes Mellitus: Randomized Controlled Trial (Preprint)
Authors: Lim Karen , Chan Shiao-Yng , Lim Su Lin , Tai Bee Choo , Tsai Cammy , Wong Su Ren , Ang Siew Min , Yew Tong Wei , Tai E Shyong , Yong Eu Leong
Published: March 2021

BACKGROUND

Women with a history of gestational diabetes mellitus (GDM) are at an increased risk of developing type 2 diabetes mellitus (T2DM). Lifestyle interventions aimed at postpartum weight loss to reduce T2DM risk have been reported, but poor compliance remains a barrier. Smartphone-based interventions may improve compliance, but data on its use in women with recent GDM are limited.

OBJECTIVE

This trial aimed to investigate the efficacy of a smartphone app in restoring optimal weight following delivery in women with GDM, in the setting of a population with high rates of GDM and type 2 diabetes.

METHODS

In this unblinded randomized controlled trial, 200 women with GDM were randomized to receive the intervention or standard care following delivery. The intervention enabled logging of weight, meals, and activity, with web-based interaction with a team comprising dieticians, a physiotherapist, and an occupational therapist. The primary outcome was an achievement of optimal weight (defined as the restoration of first trimester weight if first trimester BMI≤23 kg/m2 or weight loss of at least 5% from first trimester weight if first trimester BMI>23 kg/m2) at 4 months post partum. Secondary outcome measures included absolute weight loss, serum metabolic markers, self-reported nutritional intake, health education, and quality of life via questionnaires and user engagement in the intervention group.

RESULTS

In total, 40% (38/96) of women in the intervention group achieved optimal weight at 4 months post delivery compared with 32% (28/93) in the control group (P=.27). Compared with the control group, women in the intervention group reported significantly reduced caloric intake at 4 months after delivery (P<.001) and higher health-directed behavior scores (P=.045). The intervention group also reported increased emotional distress scores (P=.01). At 4 months, participant engagement with the intervention was maintained at 60.8% (SD 33.9%).

CONCLUSIONS

Although a statistically significant increase in women achieving healthy weight was not observed, this app remains promising, as women in the intervention group reported improved health behaviors and lower caloric intake. Importantly, the high retention rates suggest that a larger study with a longer follow-up period might confirm the effectiveness of this app for weight management.

CLINICALTRIAL

ClinicalTrials.gov NCT03324737; https://clinicaltrials.gov/ct2/show/NCT03324737

INTERNATIONAL REGISTERED REPORT

RR2-10.1186/s12889-019-7691-3
Social Media Engagement and Influenza Vaccination During the COVID-19 Pandemic: Cross-sectional Survey Study (Preprint)
Authors: Benis Arriel , Khodos Anna , Ran Sivan , Levner Eugene , Ashkenazi Shai
Published: March 2021

BACKGROUND

Vaccines are one of the most important achievements of modern medicine. However, their acceptance is only partial, with vaccine hesitancy and refusal representing a major health threat. Influenza vaccines have low compliance since repeated, annual vaccination is required. Influenza vaccines stimulate discussions both in the real world and online. Social media is currently a significant source of health and medical information. Elucidating the association between social media engagement and influenza vaccination is important and may be applicable to other vaccines, including ones against COVID-19.

OBJECTIVE

The goal of this study is to characterize profiles of social media engagement regarding the influenza vaccine and their association with knowledge and compliance in order to support improvement of future web-associated vaccination campaigns.

METHODS

A weblink to an online survey in Hebrew was disseminated over social media and messaging platforms. The survey answers were collected during April 2020. Anonymous and volunteer participants aged 21 years and over answered 30 questions related to sociodemographics; social media usage; influenza- and vaccine-related knowledge and behavior; health-related information searching, its reliability, and its influence; and COVID-19-related information searching. A univariate descriptive data analysis was performed, followed by multivariate analysis via building a decision tree to define the most important attributes associated with vaccination compliance.

RESULTS

A total of 213 subjects responded to the survey, of whom 207 were included in the analysis; the majority of the respondents were female, were aged 21 to 40 years, had 1 to 2 children, lived in central Israel, were secular Israeli natives, had higher education, and had a salary close to the national average. Most respondents (128/207, 61.8%) were not vaccinated against influenza in 2019 and used social media. Participants that used social media were younger, secular, and living in high-density agglomerations and had lower influenza vaccination rates. The perceived influence and reliability of the information on social media about COVID-19 were generally similar to those perceptions about influenza.

CONCLUSIONS

Using social media is negatively linked to compliance with seasonal influenza vaccination in this study. A high proportion of noncompliant individuals can lead to increased consumption of health care services and can, therefore, overload these health services. This is particularly crucial with a concomitant outbreak, such as COVID-19. Health care professionals should use improved and targeted health communication campaigns with the aid of experts in social media. Targeted communication, based on sociodemographic factors and personalized social media usage, might increase influenza vaccination rates and compliance with other vaccines as well.
Science communication for social inclusion: exploring science & art approaches
Authors: Matias Ana , Dias Andreia , Gonçalves Cláudia , Vicente Paulo Nuno , Mena Ana Lúcia
Published: March 2021

Engaging communities at risk of social exclusion poses a big challenge for science communicators. We schematize a framework for projects using science & art to promote social inclusion, composed of 3 phases — design, plan and collaboration; implementation; and evaluation. We present a case study that aimed to engage with a community of migrant senior women, mostly illiterate. Our findings suggest high engagement was achieved by building trust, involving emotions, choosing a relatable topic and following participatory practices. Inclusive activities occurred on the short-term, but for medium-term impact, community insiders need to be regarded as a second audience.
Brief psychotic disorder with delusion content related to the COVID-19 outbreak
Authors: Marouda Kyriaki , Mantonakis Leonidas , Kollias Konstantinos
Published: March 2021

The COVID-19 outbreak has affected millions of people globally and it also has a huge psychological impact. The objective of this case report is to outline the possible effect of the COVID-19 pandemic to the content of delusions in patients with psychosis. Α 34-year-old male with no history of mental disorder, involuntarily hospitalized due to agitation and aggression towards others, experienced grandiose delusions, referential delusions and delusions of passivity. The content of all his delusions was related to the COVID-19 pandemic. His symptoms were not proven to be caused by any physical condition or substance use disorder. He was prescribed olanzapine 10mg bd and lorazepam 2,5mg td and demonstrated significant improvement with a complete subsidence of his symptoms within a week. He was discharged after a total of 13 days with an ICD-10 diagnosis of brief psychotic disorder. At his 6 months follow-up, he reported no psychiatric symptoms. Existing literature indicates a strong relationship between life experiences and the content of delusions. This case report highlights how the stressful life event of the COVID-19 outbreak affected the content of our patient’s delusions.
Artists and psychoactive substances use
Authors: Patsika Efthymia , Malliori Minerva-Melpomeni
Published: March 2021

It is a well-established common notion that artists appear to use and abuse psychoactive substances more frequently and heavily than non-artists. The purpose of this study was to investigate if this holds true. The sample consisted of 118 participants, both artists and non-artists. They were asked to complete the ASSIST questionnaire, developed by the World Health Organization, that includes closed questions on substance use along with an additional questionnaire on demographic characteristics. The questionnaires were posted online in a digital platform. The artists scored significantly higher on substance use than the other professionals. Women reported less psychoactive substance use compared to men. The results confirmed the study hypothesis, in line with previous research findings. The number of similar studies in the international literature is limited. Our results are particularly useful but due to significant limitations of this study further investigation is suggested, as well as further examination of the causes of the phenomenon.