bluuebunny/crossref_metadata_2025 huggingface dataset:
Deslocamentos e persistências da memória: uma leitura dos depoimentos do goalkeeper Marcos Carneiro de Mendonça ao Museu da Imagem e do Som (1967-1982)
Authors: Hollanda Bernardo Buarque de
Published: December 2023

Em um intervalo de quinze anos, o ex-goleiro Marcos Carneiro de Mendonça (1894-1988) prestou dois depoimentos ao Museu da Imagem e do Som, em suas matrizes do Rio de Janeiro e de São Paulo. Ícone do chamado amadorismo na história do futebol brasileiro, tendo sido goleiro do Fluminense durante a belle époque, ídolo da seleção e protagonista do primeiro título sul-americano da modalidade em 1919, a trajetória de Marcos é alvo recorrente de interesse acadêmico entre os historiadores e pesquisadores, seja em seus aspectos biográficos e imagéticos, seja nos arquivísticos. Neste artigo revisita-se a construção da persona e do significado do atleta, enfatizando menos sua biografia, suas imagens e seu conhecido álbum de recortes, depositado na Biblioteca Nacional, e mais esses dois relatos orais. A finalidade precípua é tomar os dois depoimentos em conjunto, como se se tratasse do mesmo testemunho, dilatado no tempo, com vistas a identificar suas continuidades e descontinuidades. Reutilizar essa fonte sonora dá subsídios para entender as estratégias dos entrevistadores na assunção do passado e, em contrapartida, permite compreender como o próprio depoente constrói o pioneirismo de sua figura desportista e direciona os episódios e os aspectos da técnica futebolística, especialmente os da posição de goleiro, que considera dignos de rememoração, em consonância com o período histórico e com o espaço institucional em que as entrevistas foram concedidas.
A produção do espaço urbano da Zona Norte paulistana: o Lausanne Paulista e a família Savoy
Authors: Knabben Lucas , Atique Fernando
Published: December 2023

São Paulo atravessou intensas transformações espaciais entre o final do século XIX e o início do século XX. Com essas mudanças, impulsionadas pela chegada de imigrantes e por migrações do campo para a capital, a cidade extrapolou os limites naturais impostos pelo rio Tietê. Essa expansão da mancha urbana se deu a partir de uma atuação tanto do âmbito público quanto do privado-empresarial por meio da promoção de loteamentos e infraestrutura. Neste artigo, vamos abordar estas ações, visando compreender como a região Norte da cidade se firmava como um polo alternativo à carestia dos aluguéis nos bairros lindeiros à região central e auxiliou no processo de espraiamento da mancha urbana da capital. Para tanto, analisaremos a formação do espaço urbano além-Tietê, mostrando a atuação de promotores urbanos. A partir do parcelamento do solo de suas terras e da criação de atrativos urbanos para a ocupação desse espaço, de características ainda rurais na virada do século, os promotores lograram êxito. Especificamente, daremos destaque à formação do Lausanne Paulista, bairro originado a partir de uma gleba da família Savoy que, além do parcelamento do solo, também organizou um clube de futebol de várzea, atrativo urbano para os residentes do bairro. O artigo mostra, assim, a trajetória do Lausanne Paulista, explorando as atividades comerciais e sociais da família promotora, expondo os liames entre representação social, estratégias de comercialização do espaço e formação de sociabilidades cabíveis à área compreendida entre as escarpas da Serra da Cantareira e a várzea do Rio Tietê.
A crítica nas Histórias em Quadrinhos e a intersecção de gêneros e linguagens
Authors: Pegoraro Celbi Vagner Melo
Published: December 2023

Resenha de livro sobre histórias em quadrinhos.
Foucault e Freud no ethos cyberpunk de Kanshikan Tsunemori Akane
Authors: Marciano Neto João
Published: December 2023

Partindo dos conceitos de hibridação e transculturação debatidos por Iwabuchi, Tatsumi e Ianni, a análise discursiva do mangá Inspector Akane Tsunemori visa investigar a hipótese de um ethos próprio do cyberpunk japonês. Para sua realização, recorre-se ao conceito de biopoder de Michel Foucault para compreender as diferenças de abordagem da cibernética de Wiener presentes no cyberpunk e, por fim, as teorias psicanalíticas de Freud, auxiliadas com as de Kawai, para entender a mudança do perfil do protagonista cyberpunk e a alegoria presente no mangá.
Efficient Decoding of Large-Scale Neural Population Responses With Gaussian-Process Multiclass Regression
Authors: Greenidge C. Daniel , Scholl Benjamin , Yates Jacob L. , Pillow Jonathan W.
Published: December 2023

Neural decoding methods provide a powerful tool for quantifying the information content of neural population codes and the limits imposed by correlations in neural activity. However, standard decoding methods are prone to overfitting and scale poorly to high-dimensional settings. Here, we introduce a novel decoding method to overcome these limitations. Our approach, the gaussian process multiclass decoder (GPMD), is well suited to decoding a continuous low-dimensional variable from high-dimensional population activity and provides a platform for assessing the importance of correlations in neural population codes. The GPMD is a multinomial logistic regression model with a gaussian process prior over the decoding weights. The prior includes hyperparameters that govern the smoothness of each neuron’s decoding weights, allowing automatic pruning of uninformative neurons during inference. We provide a variational inference method for fitting the GPMD to data, which scales to hundreds or thousands of neurons and performs well even in data sets with more neurons than trials. We apply the GPMD to recordings from primary visual cortex in three species: monkey, ferret, and mouse. Our decoder achieves state-of-the-art accuracy on all three data sets and substantially outperforms independent Bayesian decoding, showing that knowledge of the correlation structure is essential for optimal decoding in all three species.
Emergence of Universal Computations Through Neural Manifold Dynamics
Authors: Gort Joan
Published: December 2023

There is growing evidence that many forms of neural computation may be implemented by low-dimensional dynamics unfolding at the population scale. However, neither the connectivity structure nor the general capabilities of these embedded dynamical processes are currently understood. In this work, the two most common formalisms of firing-rate models are evaluated using tools from analysis, topology, and nonlinear dynamics in order to provide plausible explanations for these problems. It is shown that low-rank structured connectivities predict the formation of invariant and globally attracting manifolds in all these models. Regarding the dynamics arising in these manifolds, it is proved they are topologically equivalent across the considered formalisms.

This letter also shows that under the low-rank hypothesis, the flows emerging in neural manifolds, including input-driven systems, are universal, which broadens previous findings. It explores how low-dimensional orbits can bear the production of continuous sets of muscular trajectories, the implementation of central pattern generators, and the storage of memory states. These dynamics can robustly simulate any Turing machine over arbitrary bounded memory strings, virtually endowing rate models with the power of universal computation. In addition, the letter shows how the low-rank hypothesis predicts the parsimonious correlation structure observed in cortical activity. Finally, it discusses how this theory could provide a useful tool from which to study neuropsychological phenomena using mathematical methods.
PaniniQA: Enhancing Patient Education Through Interactive Question Answering
Authors: Cai Pengshan , Yao Zonghai , Liu Fei , Wang Dakuo , Reilly Meghan , Zhou Huixue , Li Lingxi , Cao Yi , Kapoor Alok , Bajracharya Adarsha , Berlowitz Dan , Yu Hong
Published: December 2023

A patient portal allows discharged patients to access their personalized discharge instructions in electronic health records (EHRs). However, many patients have difficulty understanding or memorizing their discharge instructions (Zhao et al., 2017). In this paper, we present PaniniQA, a patient-centric interactive question answering system designed to help patients understand their discharge instructions. PaniniQA first identifies important clinical content from patients’ discharge instructions and then formulates patient-specific educational questions. In addition, PaniniQA is also equipped with answer verification functionality to provide timely feedback to correct patients’ misunderstandings. Our comprehensive automatic & human evaluation results demonstrate our PaniniQA is capable of improving patients’ mastery of their medical instructions through effective interactions.1
4Q37 and Excerpted Texts of Deuteronomy from Qumran
Authors: Dayfani Hila
Published: December 2023

Four manuscripts from Qumran Cave 4 are identified as manuscripts that constitute a collection of excerpts from Deuteronomy: 4Q37, 4Q38, 4Q41, and 4Q44. This paper focuses on 4Q37 and its contribution to understanding the larger group of Deuteronomy-excerpted texts. Based on material reconstruction of the scroll, the paper confirms that it originally included excerpts from both Deuteronomy and Exodus. This conclusion establishes the existence of a repertoire of scriptural sections that were selected and cited in special-use—probably liturgical—texts. The broader implications for the reception history of the Pentateuch in Second Temple times is that the Pentateuch was not conceptualized solely as a legal code or intellectual text but also as a text that was used in liturgy.
Reconsidering 4Q69 (4QpapIsap)
Authors: Gayer Asaf
Published: December 2023

4Q69 consists of two small papyrus fragments treating to Isa 5:28–30. Following Raffaella Cribiore’s criterion for identification of scribal exercises, an analysis of the textual variants to which the 4Q69 fragments attest will serve as a platform for exploring why the scribe(s) chose papyrus instead of parchment as his medium, the implications of the scroll’s column width, and the significance of its semi-cursive script and calligraphic traits. Engaging in a holistic assessment of the scroll’s purpose and use, this paper submits that rather than constituting a complete copy of the biblical book of Isaiah, it is a partial copy for use as a scribal exercise of a mid-level student. It thus sheds light on the educational process underlying the production of 4Q69 as the importance attached to the book of Isaiah during the Second Temple period and the book’s distinctive, authoritative status.
A new and a known species of Taeniastrotos Cressey, 1969 (Copepoda, Cyclopoida, Taeniacanthidae) parasitic on Japanese lizardfishes (Actinopterygii)
Authors: Izawa Kunihiko
Published: December 2023

Taeniastrotos tragus Dojiri & Cressey, 1987 is redescribed on the basis of specimens of both sexes recovered from Trachinocephalus myops (Forster, 1801), and T. synodi sp. nov. is described based on a single specimen of the female recovered from Synodus macrops Tanaka, 1917. The description of the male of T. tragus is the first for the species.
The effects of using different stocking volumes on the development of broodstocks of the blue crab, Callinectes sapidus Rathbun, 1896 (Brachyura, Portunidae)
Authors: Gencer Övgü
Published: December 2023

The aim of this study is to determine the effect of different stocking volumes on the survival and growth of broodstocks of the blue crab, Callinectes sapidus. Based on a Pearson correlation test, 0.70 litre tanks with three groups at different stocking densities (15, 10 and 5 individuals per tank) have been used in this study. The results show that the mortality rate due to cannibalism was high in the first test group, while it was found to be lower in the third group. There were significant differences in survival rates in the three different groups used in this trial of broodstock cultivation (). The higher the stocking densities, the lower the survival rates, i.e., significantly increasing the broodstock density reduces the survival rate.

Statistical differences have also been found in the development rates of broodstock crabs (), and it has been noted that there is slower development at higher stocking densities. If calculating the optimal stock density for mass production purposes is desired, less density thus appears to be more advantageous for both survival and growth rate.
Regulatory Choices at the Advent of Gig Warfare
Authors: Klamberg Mark
Published: December 2023

Regulation of military ai may take place in three ways. First, existing rules and principles in ihl is already or could be extended via reinterpretation to apply to military ai; second, new ai regulation may appear via “add-ons” to existing rules, finally, regulation of military ai may appear as a completely new framework, either through new state behavior that results in customary international law or through a new legal act or treaty. By introducing this typology, one may identify possible manners of regulation that are presently under-researched and/or ignored, for example how Rules of Engagement (roe) may be a way to control the use of military ai. Expanding on existing scholarship, the articles discusses how military ai may operate under different forms of military command and control systems, how regulation of military ai is not only a question of “means” but also “methods” of warfare and how the doctrine of supervisory responsibility may go beyond the doctrine of command responsibility. In the case that fully-automated Lethal Autonomous Weapons Systems (laws) are available and considered for use, it is suggested that their use should be prohibited in densely populated areas following the same logic as incendiary weapons. Further, one could introduce certain export restrictions on fully-automated laws to prevent proliferation to non-state actors and rogue states.
Hygienic indicator bacteria in the 2 species of wild-caught Japanese cicadas, large brown cicadas and robust cicadas
Authors: Ueda Takuro , Haga Bontetsu , Suzuki Hodaka
Published: December 2023

Entomophagy is considered a potent dietary practice to replace animal protein due to its highly nutritious and environmentally sustainable features. While entomophagy has many advantages, safety and security concerns still remain, especially for wild-caught insects, not farm-reared insects. This study aimed to clarify the potential microbiological hazards of eating wild-caught cicadas. Large brown cicadas and robust cicadas, which were commonly inhabited in Japan, were caught and examined the hygienic indicator bacteria, standard plate counts (SPC) and Enterobacteriaceae. Then, representative colonies of Enterobacteriaceae were identified. Also, the distribution of bacteria, i.e. the surface or inside the body of the cicadas, and the changes in the bacterial number during the storage of the dead cicadas were examined. SPC was in the range of 3.0 to 9.0 log CFU/g and Enterobacteriaceae was detected in the most of cicadas. Most of the Enterobacteriaceae species identified were biosafety level 2 pathogens or opportunistic pathogens. SPC and Enterobacteriaceae were distributed both on the surface and in the body of the cicadas. SPC and Enterobacteriaceae rapidly increased in the dead cicadas during the storage (at 25 °C). In this study, it is concluded that sufficient heat cooking and proper cold storage should be necessary for the safe consumption of cicadas as food.
Retention and excretion of microplastics by Yellow Mealworm (Tenebrio molitor) larvae reared on an amino formaldehyde polymer microbeads contaminated substrate
Authors: Randazzo B. , Uboni C. , Cardinaletti G. , Rondinella A. , Tulli F.
Published: December 2023

Yellow mealworm (Tenebrio molitor L., TM), one of the main cultured insect species, is used for feed and food. Larval stages of this species can be reared on several substrates, including grains and industrial by-products. However, this species may potentially accumulate contaminants from the substrate, including microplastics (MPs), which may represent a potential hazard for its utilization in food chain. Evidences for plastic degradation by mealworms have been reported, while there are few information about the retention of microplastics in the body and tissues of this species. The aim of the present study was to assess whether TM larvae reared on a MPs-contaminated substrate were able to retain MPs in body tissues and to evaluate the retention and excretion rate after fasting for 24 and 48 hours. For this purpose, fluorescent amino formaldehyde polymer microbeads (1-5 μm) were used to simulate a MPs contamination in the substrate used for larvae rearing. A relevant concentration of MPs were found in the gut and were associated with ingested feed. However, microscopic analyses indicated that the gut acts as a simple transit site and a barrier towards MPs migration in tissues. A marked reduction of MPS content was highlighted in larvae after fasting, even though a 48-hours fasting period was not sufficient to completely depurate insect gut from MPs. Results obtained in the present study suggest that the polymer microbeads used are recalcitrant to digestion by TM larvae, and show the relevant ability of depuration from MPs of this species. Taken together the results showed the suitability of TM to be reared on MPs contaminated substrates since larvae survival and growth resulted not hampered by the MPs presence and open cues on the fasting period able to completely depurate insect body from MPs residues.
Settlement rule of underpass railway model in shield tunnel and influence of nanomaterials on slurry performance during construction
Authors: Li Ying , Wang Minji , Yang Yawen , Guo Haoran , Zhou Yilin
Published: December 2023

In the shield tunnel, the phenomenon of structure penetration occurs frequently. Therefore, strict control of ground subsidence is imperative during the construction phase. In addition, other variables may be influence the performance of the slurry during the grouting procedure. This
study aims to investigate and analyze the impact of nanomaterials on the properties of slurry used in construction, with the goal of determining the optimal construction route for the shield, ensuring quality construction of a U-shaped section, and meeting settlement control requirements.
Firstly, the impact of double line spacing on the subsidence of U-shaped grooves is analyzed. Subsequently, the influence of common nanomaterials on slurry properties is examined through compressive strength testing. Among these nanomaterials, micro-silica powder exhibits the most significant
enhancement effect on construction slurry performance with an optimal content of 5%. If the content of silica powder reaches 5%, the initial strength and later strength of the cement slurry will increase by 35% and 25% respectively, thereby promoting the enhanced performance of the slurry.
In this study, the settlement of a U-shaped groove on the surface and subgrade is controlled by the settlement of a shield tunnel underpass railway model based on the distance between shield construction lines, providing valuable insights for future constructions with similar characteristics.
Effect and mechanism of a subanesthetic dose of esketamine on postoperative neurocognitive disorders through the regulating of the TLR4/NF-κB pathway in microglia
Authors: Zhang Yang , Xiong Mengying , Chen Shibiao , Wang Ningyan , Wang Xiuhong
Published: December 2023

Perioperative neurocognitive disorders (PND) are postoperative or anesthesia-related complications of the central nervous system, characterized by intelligence decline, memory loss, attention deficit, impaired decision-making skills, reduced language comprehension performance, and psychological
disorders. This study aims to investigate the impact of a subanesthetic dose of esketamine on PND in aged mice by regulating the microglia toll-like receptor 4 (TLR4)/nuclear factor κB (NF-κB) pathway. An exploratory laparotomy model was established in 18-month-old
C57BL/6 mice post-anesthesia. Behavioral evaluations such as open field tests and Morris water maze tests for autonomous activity and spatial learning and memory ability. Different esketamine doses were administered to aged mice, followed by behavioral assessment for autonomous activity and
learning/memory abilities. Nucleic acid extraction employed magnetic nanoparticles, while qRT-PCR measured mRNA levels of tumor necrosis factor-α, interleukin-6, and interleukin-1β. Western Blot detected the Iba-1 and TLR4 protein expression and phosphorylation status
of the P65 protein. Immunofluorescence determined the fluorescence intensity of Iba-1 and P-NF-κBp65. MTT assay evaluated cell viability. As a result, we demonstrated that a subanesthetic dose of esketamine effectively inhibited microglia activation and TLR4/NF-κB
signaling pathway both in vivo and in vitro, resulting in decreased levels of inflammatory factors and improved neuroinflammatory responses, ultimately alleviating postoperative neurocognitive dysfunction. Notably, our findings revealed that laparotomy exploratory surgery-induced
cognitive dysfunction, which can be improved by esketamine’s neuroprotective effects. Furthermore, our study also highlighted the protective effect of esketamine against lipopolysaccharide-induced inflammatory response in BV2 cells by inhibiting the TLR4/NF-κB signaling
pathway.
Long-term monitoring of SF6 decomposition gases and water molecules using TiO2-doped SnSe monolayer for generator circuit breakers
Authors: He Rufei , Cheng Li , Huang Xiaofeng , Xu Hao , Zhang Xiaojing , Zhang Xiaobo
Published: December 2023

In generator circuit breakers, monitoring the decomposition of Sulfur Hexafluoride (SF6) gas is a primary method to determine insulation and fault conditions. The presence of SF6 combined with H2O impurities also significantly impacts the degradation
of equipment insulation. However, there is a lack of research on the simultaneous monitoring of both SF6 decomposition and H2O. To improve the system’s rapid recoverability, recyclability, and long-term usability, a SnSe monolayer doped with TiO2 nanoparticles
(SnSe–TiO2) has been proposed as an SF6 gas decomposer detection sensor with humidity detection capabilities. The SnSe–TiO2 monolayer significantly enhances the conductivity and increases its adsorption energy for H2O (73.2%), H2S
(13.54%), HF (59.70%), SO2 (96.33%), and SOF2 (52.04%). Furthermore, this material can be utilized for long-term cyclic gas monitoring as the SnSe–TiO2 monolayer is physically adsorbed to these gases and can be rapidly desorbed. This study establishes a theoretical
foundation for the future advancement of gas detection sensors for insulating gases in circuit breakers.
Yb@TiO2 nanoparticles as a SELDI-TOF MS matrix for the simultaneous measurement of Tetrabromobisphenol A and Perfluorooctane sulfonate
Authors: Yang Jing , Luo Chunhua , Xiong Lihao , Fu Lichun , Luo Xiaohu , Gao Linxiao , Zhou Huang , Yang Lixia , Yang Fei , Zhen Deshuai
Published: December 2023

Ytterbium modified TiO2 nanoparticles (Yb@TiO2), synthesized by a sol–gel process, were employed as an efficient adsorbent and matrix for the analysis of Perfluorooctane sulfonate (PFOS) and Tetrabromobisphenol A (TBBPA) via surface-enhanced laser desorption/ionization
time-of-flight mass spectrometry (SELDI-TOF MS). The detection limits for PFOS and TBBPA are achievement with 0.01 pg ·mL−1. The results of the analysis of camellia oil samples show good recovery (80.3%–86.8%) with a low detection limit for TBBPA.
Regulatory mechanism of LINC00657/MiR-26b in the TNF-α/NF-κB pathway for the progression of colorectal cancer
Authors: Zhang Shengjun , Liu Minli , Zhao Ajing , Zhang Anrui , Li Yawei , Li Xiaobao
Published: December 2023

This study investigates the effect of long-chain non-coding LINC00657 on cell proliferation and apoptosis in colorectal cancer and its molecular mechanism based on magnetic nanocarriers for gene delivery. Tumor tissues were collected from patients with colorectal cancer (CRC) to examine
the expression of LINC00657. Magnetic nano microspheres were prepared and CRC cells were transfected with short hairpin RNA (shRNA) targeting LINC00657 to establish a stably transfected cell line. The binding relationship between LINC00657 and MicroRNA-26b (MiR-26b) was also verified using
a dual-luciferase gene reporter assay. The expression of LINC00657 and MiR-26b were determined by qRT-PCR and Western blot. Cell proliferation, migration, and apoptosis were assessed. Our findings reveal that LINC00657 is highly expressed in CRC tissues and cells, significantly promoting hepatoma
carcinoma cell proliferation and migration. Furthermore, we demonstrate that MiR-26b can target and bind to LINC00657, while its expression decreases in CRC cells. Knockdown of LINC00657 resulted in significant downregulation of both MiR-26b expression levels and tumor necrosis factor-α
(TNF-α)/nuclear factor-kappa B (NF-κB) pathway activity. However, co-transfection of a MiR-26b inhibitor into sh-LINC00657-transfected cells attenuated the effects on malignant phenotypes while activating TNF-α/NF-kB pathway activity. Conversely, transfection
of an NF-kB activator exerted similar effects as the MiR-26b inhibitor by enhancing malignant proliferation ability in CRC cells. Overall, the upregulation of LINC00657 potentially modulates the proliferation and apoptosis of colorectal cancer cells through its interaction with MiR-26b, leading
to the activation of the TNF-α/NF-κB signaling pathway.
The mechanism of metallothionein MT1M-mediated PI3K/AKT signaling pathway in the regulation of diabetic retinopathy
Authors: Gao Lu , Song Fangling , Liu Ting
Published: December 2023

Metallothionein (MT1M) is associated with tumors and autoimmune diseases. However, its role in DR has not yet been elucidated. DR and normal rat retinal endothelial cells (RECs) were isolated and cultured. DR Rat RECs achieved gene regulation by transfecting MT1M plasmid. PCR and MTT
were used to detect MT1M expression, cell proliferation. Flow cytometry was used to detect cell apoptosis. Lactate dehydrogenase (LDH), superoxide dismutase (SOD) and reactive oxygen species (ROS) were detected by MTT. The expression of VEGF and PI3K/AKT signaling pathway was detected by Western
blot. The levels of inflammatory factors TNF-α and IL-1β were detected by ELISA. The results showed that the expression of MT1M was reduced in the RECs of DRC rats compared to the normal control group, cell proliferation was enhanced, SOD activity was reduced, LDH
and ROS levels were increased, TNF-α and IL-1β secretion increased, and vascular endothelial growth factor (VEGF), PI3K/AKT expression increased (P < 0.05). However, transfection with MT1M plasmid could significantly inhibit cell proliferation, increase SOD
activity, reduce LDH and ROS levels, reduce TNF-α and IL-1β secretion, and reduce VEGF and PI3K/AKT expression (P <0.05). The expression of MT1M is reduced in RECs of DR rats. Up-regulation of MT1M can regulate DR3K/AKT signaling pathway and oxidative/antioxidant
balance, alter VEGF expression, inhibit inflammation, regulate the growth and proliferation of RECs, and delay DR lesions.
Mechanism of montelukast on autophagy and apoptosis of airway epithelial cells through STAT3-RORγt-IL-17/IL-23 signaling pathway
Authors: Xu Hui , Wang Xiurong , Du Bin
Published: December 2023

This study investigates the mechanism of montelukast intervention on autophagy and apoptosis of airway epithelial cells. Construction of HBE cell building model, which were intervened by montelukast. The proliferation of human 16HBE cells was detected using MTT method and β-catenin
level was detected. The cellular cycle distribution, autophagy and apoptosis were detected using flow cytometry. And expressions of Transcriptional activator 3 (STAT3)-Retinoic acid-associated nuclear orphan receptor (RORγt)-interleukin 17 (IL-17)/interleukin 23 (IL-23) signaling
related proteins were measured using Western blot. Montelukast inhibited the proliferation of human 16HBE cells and its inhibition rate and action concentration showed time and dose dependence. The half maximal inhibitory concentrations (IC50) were (12.8±0.67) μmol/L at 24
h, (8.8±0.43) μmol/L at 48 h and (6.6±0.42) μmol/L at 72 h, respectively. Montelukast induced 16HBE cellular cycle to arrest in G2/M phase dose-dependently (5, 10 and 20 μmol/L) (P <0.05) and simultaneously increased apoptosis rate (P
< 0.05). 40 μL montelukast had a protective effect on 16HBE cells. In addition, montelukast reduced β-catenin level, which suggested that STAT3-RORγt-IL-17/IL-23 signaling pathway might be inhibited. Meanwhile, montelukast reduced the expressions of STAT3,
P-STAT3, RORγt (RORβ), c-myc and survivin and increased protein expressions of GSK-3 (RORα) and Th17, but had no effect on the total RORγt level. Montelukast may effectively promote the apoptosis of 16HBE airway epithelial cells via inhibition
of STAT3-RORγt-IL-17/IL-23 signaling.
Curcumin targets miR-1297 to promote mitochondrial apoptosis and cisplatin sensitization of lung cancer stem cells
Authors: Sun Jiayang , Gang Luzhi , Li Chunlin
Published: December 2023

The medicinal value of curcumin has been confirmed in many diseases. This study explores miR-1297’s role in lung cancer cells. The targeting regulation between miR-1297 and BH3-only was analyzed by luciferase activity. Cisplatin (DDP)-resistant cell lines A549/DDP and NCI-H460/DDP
were established followed by analysis of cell proliferation activity, BH3-only expression, and cell proliferation by EdU staining. miR-1297 targets BH3-only. miR-1297 expression in A549/DDP and NCI-H460/DDP cells was significantly increased while BH3-only was reduced. Same dose of DDP inhibited
the proliferation of A549/DDP and NCI-H460/DDP cells. BH3-only in A549/DDP and NCI-H460/DDP cells in miR-1297 inhibitor transfection group was significantly increased, apoptosis was increased, proliferation was weakened, and drug resistance was reduced. Lung cancer DDP resistance is related
to the expression of miR-1297. Down-regulation of miR-1297 can reduce the DDP drug resistance by increasing the expression of BH3-only.
Placement of Intracranial Pressure Monitors by Non-neurosurgeons: A Follow-Up Study
Authors: Jumpa Dania , Lightwine Kelly , Ablah Elizabeth , Okut Hayrettin , Grundmeyer Raymond , Haan James M.
Published: December 2023

Background

Some research suggests that physicians who are not neurosurgeons can safely place intracranial pressure (ICP) monitors. The purpose of this study was to compare intracranial pressure monitor placement complications between neurosurgeons, trauma physicians, and general surgery residents. We hypothesized that with appropriate training, general residents can safely place ICP monitors.

Methods

A 10-year retrospective chart review of all trauma patients that required ICP monitor placement between January 1, 2012, and December 31, 2021, was conducted. Comparisons were made between treatment groups.

Results

During the study period, 194 patients required ICP monitor placement. General surgery residents placed 94.3% of ICP monitors, 3.6% were placed by attending trauma physicians, and 2.1% by neurosurgeons. No ICP monitors were placed by attending trauma physicians or neurosurgeons between 2015 and 2018. Overall, minor complications during ICP monitor placement included device malfunction (2.7%) and inaccurate readings (.5%). There were no major complications during ICP monitor placement. Post-ICP monitor placement complications included one patient who experienced a central nervous system infection (.5%) and three patients who had mechanical problems (1.5%). No complications occurred among the neurosurgeon or attending trauma physician treatment groups.

Conclusion

Most intracranial pressure monitors in our study sample were safely placed by surgical residents. Based on our study findings and considering the shortage and downtrend of neurosurgery specialists, ICP bolt placement needs to become a core clinical skill in surgical resident programs across the United States.
Pelvic Organ Prolapse and its Associated Factors Among Women: A Facility Based Cross-sectional Study
Authors: Merga Adamu , Bidira Kebebe , Geda Abdi , Nigatu Desalegn , Bayana Ebissa
Published: December 2023

Pelvic organ prolapse is the downward descent of female organs, including the bladder, small bowel, and large bowel, resulting in the protrusion of the vagina, uterus, or both. This disorder, exclusive to women, causes psychological trauma and social withdrawal, leading to an increased rate of gynecologic surgery. To assess the Pelvic Organ Prolapse and its associated factors among Women Visiting public Hospitals in south west Ethiopia. An institution-based cross-sectional study was conducted among gynecologic patients. A total sample size of 408 was allocated to the institutions proportional to their previous month’s case load. Data were collected using an interviewer-administered structured questionnaire. The collected data were coded and entered into EpiData version 3.1, then exported to SPSS version 20 for descriptive and inferential analysis. Adjusted odds ratios (AOR) along with a 95% confidence level were estimated, and a P-value < .05 was considered statistically significant. Out of the intended sample size, 393 women participated in the study, resulting in a response rate of 96.3%. The overall magnitude of pelvic organ prolapse among the study participants was 19.8% (95% CI: 16.0, 24.1). Factors significantly associated with pelvic organ prolapse were place of residence (AOR = 2.21, 95% CI: 1.11, 4.40), parity (AOR = 2.82, 95% CI: 1.39, 5.72), age at first pregnancy (AOR = 2.32, 95% CI: 1.27, 4.26), and place of delivery of the first child (AOR = 4.18, 95% CI: 1.97, 8.85). The prevalence of pelvic organ prolapse is high. Place of residence, parity, age at first pregnancy, and place of delivery of the first child were factors significantly associated with pelvic organ prolapse. Therefore, different stakeholders, programmers, and implementers should take aggressive steps to prevent early pregnancy, train health professionals to encourage women to use family planning, and promote institutional delivery.
Assessing a Model of Customer Rage: Does Customer Entitlement Moderate Relationships Between Rage Emotions, Expressions and Behaviors?
Authors: Rasoolimanesh S. Mostafa , Gannon Martin , Taheri Babak , Mikulić Josip
Published: December 2023

Across travel and tourism services research, studies investigating “customer rage” typically prioritize the direct point-of-consumption, often within airport, airline, or hotel contexts. However, the sector is awash with intermediaries (e.g., travel agencies, insurance brokers, booking platforms), which serve as primary points-of-contact capable of shaping customer expectations. Accordingly, the consequences of service failure therein are nuanced and complex. Yet, extant research often portrays service failure as unilateral (i.e., solely the firm in question’s responsibility), overlooking one core demand-side characteristic: the customer’s sense of entitlement. Thus, while this study draws upon the Iranian travel agency setting (as a service intermediary) to assess a model of customer rage, it also explores whether customer entitlement moderates the relationships between customers’ rage emotions, expressions, and behaviors. Doing so, 736 survey responses were analyzed. Findings demonstrate how customer rage emerges in response to service failure, alongside the conditions under which customer entitlement moderates relationships therein.
Differences in Destination Attachment Representations of First-Time and Repeat Tourists
Authors: Qu Ying , Zhou Qing , Guo Yangfeng , Yang Hongyan
Published: December 2023

The concept of destination attachment originates from the “people-people” attachment research but has not been investigated from this perspective, resulting in a substantial research gap. This study applied the concept of adult attachment to conceptualize, classify, and measure destination attachment. Different formation mechanisms, the effect range of the destination attachment representations of first-time and repeat tourists, and the relationships between the destination attachment representations and general attachment representations of tourists were examined. The findings were in line with the theoretical expectations. This study is innovative because it expands the research scope of destination attachment, proposing the necessity of developing formative measurement dimensions of destination attachment and elucidating the meanings of the relationship between the attachment representations of first-time and repeat tourists in tourist loyalty research. Managerially, this study has practical value for shaping destination attachment and attracting/cultivating repeat tourists.
The Diachronic Development of Agency Prepositions in Old and Middle English
Authors: Cichosz Anna , Karasińska Sylwia
Published: December 2023

This article traces the development of agency prepositions in Old and Middle English passives, documenting the most important stages of the process and presenting them against a larger background of linguistic changes after the Norman Conquest. The study is based on large, syntactically annotated corpora of Early English, and takes into account all the main agency prepositions, that is, þurh ‘through,’ fram ‘from,’ mid ‘with,’ bi ‘by,’ and of, analyzing their token and type frequency, textual distribution, diachronic trends, collocational preferences, and use in lexically fixed formulas. The results are interpreted within the Construction Grammar framework, with the agency prepositional phrase treated as an emerging construction undergoing a slow and particularly difficult constructionalization process hindered by the restriction of the long passive to the written mode.
Sensor-algorithmic Virtuality: Machinic World-making on Mars
Authors: Sprenger Florian
Published: December 2023

To understand how robots, such as self-driving cars, drones, or rovers, generate spaces of interaction, it is important to move away from the idea that they simply represent the world through their sensors and then decide upon an appropriate action to reach a predefined goal. The question is how they generate their own worlds in the first place. This article reassesses the concept of virtuality as an analytical tool to describe the world-making capacities of autonomous, environmentally adaptive machines. Such robots employ the probabilities of virtual world models, generated by algorithmically filtering sensor data, as statistical specifications. This sensor-algorithmic virtuality enables them to decide upon actions to be actualized in the real world by playing through a multiplicity of virtual options. They don’t have access to an outside view but rather operate based on a multiplicity of virtual, possible, and more or less probable worlds. In a case study on the Mars rover Perseverance, this article describes in detail the technical procedures and the underlying epistemological challenges of machinic virtuality and shows that this virtuality—as a multiplicity of virtual worlds—rests upon the algorithmic filtering of sensor data.
Canine follicular cell and medullary thyroid carcinomas: Immunohistochemical characterization
Authors: Jankovic Jana , Tièche Eve , Dettwiler Martina , Hahn Kerstin , Scheemaeker Stephanie , Kessler Martin , Daminet Sylvie , Rottenberg Sven , Campos Miguel
Published: December 2023

Research on modulation of iodine uptake by thyroid cells could help improve radioiodine treatment of dogs with thyroid tumors. The aim of this study was to characterize the immunohistochemical expression of thyroid transcription factor-1 (TTF-1), thyroglobulin, thyrotropin receptor (TSHR), sodium iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), vimentin, and Ki-67 in follicular cell thyroid carcinomas (FTCs) and medullary thyroid carcinomas (MTCs), and to compare protein expression between FTC causing hyperthyroidism and FTC of euthyroid dogs. Immunohistochemistry was performed in 25 FTCs (9 follicular, 8 follicular-compact, and 8 compact) and 8 MTCs. FTCs and MTCs were positive for TTF-1, and expression was higher in FTCs of euthyroid dogs compared with FTCs of hyperthyroid dogs ( P= .041). Immunolabeling for thyroglobulin was higher in follicular and follicular-compact FTCs compared with compact FTCs ( P = .001), while vimentin expression was higher in follicular-compact FTCs compared with follicular FTCs ( P = .011). The expression of TSHR, NIS, pendrin, and TPO was not significantly different among the different subtypes of FTCs or between FTCs causing hyperthyroidism and FTCs in euthyroid dogs. TSHR, NIS, pendrin, and TPO were also expressed in MTCs. Ki-67 labeling index was comparable between FTCs and MTCs, and between FTCs causing hyperthyroidism and FTCs in euthyroid dogs. Proteins of iodine transport were also expressed in canine MTCs, which could have implications for diagnosis and treatment. The different expression of thyroglobulin and vimentin between FTC histological subtypes could reflect variations in tumor differentiation.
A review on the influence of various metal oxide nanoparticles on structural, morphological, optical, thermal and electrical properties of PVA/PVP blends
Authors: Meera K , Ramesan MT
Published: December 2023

Biopolymer blend based nanocomposites have been interestingly investigated by researchers to achieve advanced composite functional materials that are environmentally amicable. Among the varieties of biopolymers, widespread attention has been given to polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) owing to their interesting properties like water solubility, biodegradability, biocompatibility and non-toxicity. PVA and PVP form a completely miscible blend at all compositions as both the polymers are rich in a variety of functional groups that permit effective intermolecular interactions between the polymers as well as with filler. PVA/PVP blend exhibits excellent dopant sensitive properties also. Metal oxide nanoparticles (MONPs) have made a prominent place in the area of scientific and technological research due to their unique chemical and physical properties. Doping with MONPs enhances the properties of the PVA/PVP blend matrix and the resulting PVA/PVP/MONP polymer nanocomposites are suitable for multifunctional purposes. This review mainly focused on the influence of various MONPs such as ZnO, CuO, Al2O3, ZrO2, MnO, SnO, MgO, TiO2, etc. in the structural, morphological, thermal, optical and electrical properties of PVA/PVP blend as well as its applications in various fields.
Embracing collaborations between festivals and higher education: A case study of the ‘Decolonising film festivals and curating African cinemas’ networking event at King’s College London
Authors: Sendra Estrella
Published: December 2023

In recent years, there has been an increasing awareness of the social responsibility of Higher Education, encouraging knowledge exchange initiatives and impact. This often involves the collaboration with the industry, embracing a curatorial turn in the pedagogic approach. This self-reflexive case study shares the learning, challenges, and opportunities offered by the organisation of a networking event named ‘Decolonising Film Festivals and Curating African Cinemas.’ In so doing, it seeks to offer insights into one such forms of collaboration between Higher Education and the Industry. Through an analysis of the feedback by participants and the discussions at a round-table on decolonising, it highlights the horizontalism and distended environment of the experience, fostering a safe and fruitful discussion that engages in a call to action towards to sought change. In public facing events hosted at the university, the classroom becomes a brainstorming exercise in collaboration. The curatorial turn adopted through collaboration bridges theory and practice. Itlurifies voices in the learning and teaching experience, and collaboratively rehearses potential creative solutions to real life scenarios. It promotes social justice, engaging all participants in the process.
Study on electromechanical coupling inherent vibration characteristics and parameter influencing law of EMT system used in HEV
Authors: Liu Hui , Xie Yunkun , Wu Yunhao , Gao Pu , Han Lijin , Xiang Changle , Ma Yue , Yan Keyu , Yan Qi , Gai Jiangtao , Shuai Zhibin
Published: December 2023

As high-speed, heavy-load, and high-power density are realized in hybrid electric vehicle (HEV), the electromechanical coupling inherent vibration of electromechanical composite transmission (EMT) system becomes the bottleneck in this study area. To reduce vibration, the analysis of inherent vibration characteristics of EMT system and parameter influencing law of mechanical-electro-magnetic parameter is key. Here, an electromechanical coupling dynamics model is established considering multi-source excitations, and the inherent vibration model is obtained. Based on this inherent vibration model, firstly, the inherent vibration frequency and mode with and without electromagnetic effect of EMT system are studied and summarized. Secondly, the resonance speed of EMT system is identified based on Campbell diagram and modal energy method. Thirdly, the inherent frequency trajectory and variation law affected by PMSM parameters (inner power factor angle (IPFA), armature current, stator-rotor eccentricity) and the mode mutations phenomenon of inherent frequency trajectory caused by PG parameter (connecting, gear meshing, and bearing support stiffness) are studied. This study results provide a reference for the modeling and analysis of inherent vibration characteristics, as well as the design and optimization of mechanical-electro-magnetic parameter of EMT system.
Digital Enhancement: A Drawbridge or a Detachment of the Digital Divide
Authors: Chhanchhuahi Vanlal , Deka Junali
Published: December 2023

Mizoram, one of the smallest states in India, has a very dynamic and flexible culture. The internet reached the state during the late 1990s; the general public started accessing it by the early 2000s. Digital enhancement, facilitated by technological devices, is becoming a reality in various professions as well as daily life. The problem of the digital divide—tangible availability of computers and internet connections as well as issues of content, language, skills and social resources—is yet challenging to eradicate. Whilst a group called the ‘choose nots’ are not interested in engaging with technology, several questions arise—Will digital know-how be useful in bridging the gap of the digital divide? Can digital understanding outdo the divide demarcated by the native–immigrant separation? Or does digital enhancement widen the gap by endowing the ‘haves’ while the ‘have-nots’ keep adding numbers to the ‘digital left behind’? This study focuses on the influence of the internet on Mizo culture, nature of the digital divide, and traces the internet history of Mizoram while trying to map the perceived difference in communication behaviour before and after the existence of the internet among digital immigrants.
Various Factors Influencing the Enantiomers of Warfarin Pharmacokinetics: A Systematic Review of Population Pharmacokinetics
Authors: Mahaboob Sirajudeen , Ganesh G.N.K. , Arun K.P. , Rajendran S.D.
Published: December 2023

Warfarin is the most commonly prescribed anti-coagulant medication. Warfarin’s pharmacokinetics (PK) in its enantiomeric form have been reported to be highly variable. Five population pharmacokinetic model studies for warfarin were identified in this systematic review. This review summarized these studies and reported on various factors affecting warfarin PK. Most studies reported a one-compartment model with first-order absorption and elimination for both S-warfarin and R-warfarin. Warfarin disposition has been reported to be influenced by various factors, including gender, age, genetic variation, body surface area (BSA), concurrent drug, weight, and ethnicity. So, all of these factors must be considered when addressing this pharmacokinetic variability. These models should undergo an external evaluation to confirm their generalizability and to support model-informed dosing in clinical settings.