bluuebunny/crossref_metadata_2025 huggingface dataset:
Classic Hodgkin Lymphoma – mixed cellularity – case report and review of literature
Authors:   Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania, Oprea-Lebedenco Mihaela ,   Ambulatory of Hematology, “Sf. Ioan” Emergency Clinical Hospital, Bucharest, Romania, Berbec Nicoleta ,   Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania, Stanca Oana ,   Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania, Turbatu Andrei ,   Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania, Marin Stefan ,   Ambulatory of Hematology, “Sf. Ioan” Emergency Clinical Hospital, Bucharest, Romania, Dobrea Camelia ,   Department of Hematology, Fundeni Clinical Institute, Bucharest, Romania, Andreescu Mihaela ,   Ambulatory of Hematology, “Sf. Ioan” Emergency Clinical Hospital, Bucharest, Romania, Lupu Anca Roxana ,   Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania
Published: May 2023

Hodgkin's lymphoma, formerly known as Hodgkin's disease, is a type of cancer of the lymphatic system, an important part of the site where immune processes take place. The disease can affect people of any age, but it is much more common in the age range of 20-40 years and in people over 55 years old. In Hodgkin's lymphoma, cells in the lymphatic system multiply uncontrollably and can spread outside of it. Advances in the diagnosis and treatment of Hodgkin's lymphomas present a chance for patients to achieve a complete remission of this type of cancer. The prognosis is constantly improving for people with this diagnosis. This article will present the case of a 27-year-old patient with classic Hodgkin's lymphoma - histological subtype mixed cellularity - chemo refractory.
Hubungan antara Komunikasi dalam Keluarga dengan Kemampuan Bicara Anak Usia Dini di Kampung Pisang Kecamatan Kinali Kabupaten Pasaman Barat
Authors: Shaumi Annisa Miftahus , Ismaniar
Published: May 2023

Penelitian ini dilatarbelakangi oleh rendahnya kemampuan bicara anak usia dini di Kampung Pisang Kecamatan Kinali Kabupaten Pasaman Barat. Diduga salah satu penyebabnya adalah karena komunikasi yang diterapkan dalam keluarga kurang tepat. Penelitian ini bertujuan untuk: 1) menggambarkan komunikasi yang terjadi dalam keluarga; 2) menggambarkan kemampuan bicara anak usia dini; dan 3) melihat hubungan antara komunikasi dalam keluarga dengan kemampuan bicara anak usia di Kampung Pisang, Kecamatan Kinali, Kabupaten Pasaman Barat. Penelitian ini merupakan penelitian kuantitatif korelasional. Populasi dalam penelitian ini ialah ibu-ibu rumah tangga yang berjumlah 26 orang yang mempunyai anak usia 4-5 tahun. Sampel berjumlah 19 orang dengan pengambilan sampel menggunakan teknik simple random sampling. Teknik pengumpulan data mengunakan angket dan observasi perkembangan kemampuan bicara anak usia dini, data yang diperoleh dianalisis menggunakan analisis deskriptif dan rumus korelasi korelasi Sperman Rho. Hasil penelitian menunjukkan: 1) komunikasi yang terjadi dalam keluarga di Kampung Pisang dikategorikan kurang tepat; 2) kemampuan berbicara anak usia dini di Kampung Pisang masih rendah; dan 3) terdapat hubungan yang cukup signifikan antara komunikasi dalam keluarga dengan kemampuan bicara anak usia dini di Kampung Pisang, Kecamatan Kinali, Kabupaten Pasaman Barat.
Hubungan antara Social Comparison dengan Body Image Dewasa awal Pengguna Media Sosial Tiktok
Authors: Intan Dinata Rahayu , Pratama Mario
Published: May 2023

Aplikasi Tiktok merupakan media sosial yang tengah viral di Indonesia dan yang paling banyak menggunakannya adalah dari umur 15-24 yang dimana dewasa awal masuk kedalamnya. Pada aplikasi Tiktok ini, kita hanya dapat mengunggah dalam bentuk format video, sehingga banyak yang menampilkan video wanita atau pria yang bertubuh ideal. Hal ini menyebabkan yang melihat melakukan perbandingan sosial sebagai bentuk evaluasi diri yang berkaitan dengan cara seseorang menggambarkan citra tubuhnya. Tujuan penelitian ini adalah untuk mengetahui hubungan antara perbandingan sosial dan citra tubuh dewasa awal pengguna aplikasi Tiktok dengan populasi penelitian sebanyak 206 orang. Metode penelitian ini menggunakan pendekatan kuantitatif. Penelitian ini menggunakan analisis bivariete untuk mengetahui hubungan kedua variabel. Pada uji hipotesis didapatkan bahwa terdapat hubungan signifikan positif antara perbandingan sosial dan citra tubuh (rxy=0.167, p<0.05). Hal tersebut menunjukkan terdapat hubungan signifikan positif antara social comparison dengan body image.
EDITORIAL
Authors: Inozemtsev M. I.
Published: May 2023

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Que dit la HAS de la grille PRÉAUT ?
Authors: Saint-Georges Catherine , Crespin Graciela C.
Published: May 2023

Cet article, volontairement court et factuel, résume les principaux résultats validés des recherches préaut en population générale et dans un groupe de bébés à risque ; il présente clairement la place de ces recherches dans l’argumentaire des recommandations de la has datées de 2018 concernant le dépistage et le diagnostic précoces des tsa . À cette lecture, si la has s’en tient à recommander la chat r/f à 18 mois, la piste d’une utilisation de la grille préaut beaucoup plus précocement reste tout à fait envisageable.
Pédagogie et soins dans l’autisme en Côte d’Ivoire : évaluation et perspectives de l’atelier-classe
Authors: Bissouma Anna-Corinne , Adjobi Saturnin , Janin-Duc Dominique , Diarrassouba Adjara , Djama Jocelyne , Gnepa Guillaume , Koffi Semingnon , Nouffe Vanessa , Yeo-Tenena Yessonguilana Jean-Marie
Published: May 2023

L’évolution du dispositif des ateliers-classe à Abidjan s’interroge dans cet article. Les auteurs font le point sur les évolutions et les avancées ainsi que l’impact sur les enfants pris dans ce dispositif. Les écueils du soin, liés aux difficultés de représentation des intervenants sur la pédagogie à partir des pratiques en Côte d’Ivoire, n’entravent pas l’expérience. Ces difficultés ouvrent de nouveaux chantiers de réflexion, de formation et de mise en pratique qui s’enracinent dans l’analyse de l’activité lecture en croisant le point de vue du pédagogue et du clinicien. Cet article est l’occasion de faire un point d’étape et d’ouvrir de nouveaux chemins.
AAA, Autisme Afrique Alliance avec PREAUT – Rencontre avec d’autres représentations de l’autisme – Perspectives
Authors: Janin-Duc Dominique
Published: May 2023

Cet article présente les rencontres qui ont permis la création de l’association aaa  : Autismes Afrique Alliance. préaut participe à cette démarche à partir d’une première rencontre entre une famille de Côte d’Ivoire avec son fils diagnostiqué tsa et des professionnels de l’autisme – qui ouvrira sur une première formation à Grenoble, et permettra ensuite des échanges de savoirs et de pratiques lors de nombreux voyages. Cinq pays africains sont concernés. Ces échanges sont portés par une langue française multiple, enrichie par les autres langues africaines et les cultures traditionnelles où les symptômes sont lus comme un désordre pour le groupe social. La découverte mutuelle de deux univers où les représentations et les modes de traitement de la différence et du handicap sont si étrangers l’un à l’autre va être à l’origine d’un élan de travail et de partage et donner lieu à des savoirs nouveaux.
Se confronter à la norme : masculinités, sexualités et savoirs dans les journaux d’Alexandre Brongniart (1790-1802)
Authors: Valverde Mathias
Published: May 2023

Nous proposons dans cet article une lecture du journal personnel du savant Alexandre Brongniart (1770-1847) à l’aune des études féministes sur les masculinités. À partir des traces écrites laissées par cet homme, nous étudions le parcours réflexif d’un jeune savant pendant la période révolutionnaire qui se compare et se confronte aux normes de genre. D’un sentiment de ne pas correspondre à une masculinité reposant sur la séduction active de femmes en vue d’un mariage offrant une position patriarcale, nous questionnons ici la façon dont la domination masculine se perpétue dans les pratiques et les formes ordinaires de la normativité. En analysant cette source exceptionnelle, nous souhaitons en savoir un peu plus sur l’organisation des masculinités savantes au tournant du 19 e  siècle.
La minoration de Du Châtelet par l’édition de ses textes
Authors: Coissard Guillaume
Published: May 2023

J’analyse, via l’histoire éditoriale de ses textes, la manière dont Émilie Du Châtelet a subi, aux 18 e  et 19 e  siècles, un processus de minoration qui a conduit à l’oubli de cette figure majeure des Lumières. L’étude des préfaces et des introductions au Discours sur le bonheur (1779 et 1796) montre comment le Discours est présenté comme un texte de femmes écrit pour les femmes, occultant ainsi sa dimension philosophique. Je montre ensuite que, dans la première moitié du 19 e  siècle, c’est la correspondance qui retient l’attention des éditeurs en tant qu’elle représente un genre de littérature féminine par excellence. La minoration de la figure de Du Châtelet ne correspond pas à une absence de diffusion de ses textes, mais à un travail d’édition, de présentation et de diffusion spécifique qui rend impossible la reconnaissance de son œuvre propre.
Agency, norms, and community: young workers’ intimacy and sexual culture in Old Regime France
Authors: Hardwick Julie
Published: May 2023

Cet article explore la manière dont les jeunes femmes célibataires des quartiers populaires de Lyon ont mobilisé leur communauté et le système juridique pour gérer leurs relations avec les jeunes hommes dans un monde de rapports de genre asymétriques. Il s’appuie sur un matériau que j’appelle “les archives de la reproduction” (registres publics de questions généralement non documentées) pour révéler l’histoire des relations des jeunes couples, de leur point de vue et de celui des autres. Son étude démontre comment les femmes pouvaient atténuer les effets de l’imprévisibilité des hommes en tant que partenaires sexuels et affectifs. Les jeunes femmes bénéficiaient (généralement) du soutien de leur communauté, du clergé et du tribunal pour tenir les jeunes hommes pour responsables des conséquences reproductives de leur activité sexuelle. La dynamique de cette riche culture sexuelle met en lumière les enjeux des normes de l’Ancien Régime en matière d’intimité pour les jeunes, l’Église, l’État et les quartiers populaires.
Identifications féminines, solidarités politiques et question sociale chez Staël et Charrière
Authors: Lenne-Cornuez Johanna
Published: May 2023

S’attachant à définir la forme politique que la solidarité féminine peut prendre à la fin du 18 e  siècle, cette contribution analyse deux discours : celui de Germaine de Staël compatissant avec le sort réservé à Marie-Antoinette, la reine déchue, et celui d’Isabelle de Charrière exprimant son indignation face au traitement infligé à Thérèse Levasseur, la femme de Rousseau. La comparaison de ces deux formes d’engagement public permet de montrer l’indissociabilité entre la réflexion sur la condition féminine et celle sur la condition sociale. L’énonciation féminine de soi, la revendication d’une solidarité impartiale, l’engagement dans une cause féministe et la constitution d’un sujet collectif féminin par l’expression de sa solidarité sont les aspects remarquables qui justifient le rapprochement de ces deux textes, mais font aussi émerger ce qui les sépare dans les rapports d’inclusion et d’exclusion qu’ils impliquent, traversés par la question sociale. Dans ces deux formes de solidarité se jouent alors deux manières d’assumer l’héritage de Rousseau.
Normes de genre et mariage dans le roman : de Burney à Souza
Authors: Vanoflen Laurence
Published: May 2023

L’exemple d’un conte de Marmontel permet à l’historienne Anne Verjus de suggérer le rôle joué par la fiction, à la fin de l’Ancien Régime, pour opérer une révolution des mœurs et imposer un nouveau modèle reposant sur l’unité d’intérêt indivisible du couple ( Le Bon mari. Une histoire politique des hommes et des femmes à l’époque révolutionnaire , Fayard, 2010). Pour mesurer la réaction de romancières à ce modèle, je propose d’étudier la réécriture, presque diamétralement opposée, d’un roman de Fanny Burney, Camilla , publié en 1796, par deux romancières en France et en Suisse : Isabelle de Gélieu (aidée d’Isabelle de Charrière) dans Louise et Albert ou le danger d’être trop exigeant (1803), et Adélaïde de Souza, dans le plus conformiste Charles et Marie (1802). La première conteste le stéréotype de l’amant censeur, incarnation d’une raison infaillible, et bouscule la logique de genre présidant aux conventions narratives. La seconde adopte le point de vue masculin pour décrire, dans Marie, un idéal féminin de soumission, qui incarne le nouveau modèle du conjugalisme, dans lequel « les conflits sont supposés solubles grâce à l’autorité de l’un et à la soumission volontaire de l’autre » (A. Verjus).
« “Un tout lié, dont les parties ont une correspondance nécessaire” : l’édition numérique de d’Holbach »
Authors: Sciuto Ruggero
Published: May 2023

Lancé en 2018, Digital d’Holbach est un projet international visant à réaliser une édition critique née-numérique des œuvres du baron d’Holbach. Cet article fait le point sur les principaux accomplissements de notre équipe (la publication, notamment, de la base de données Tout d’Holbach ) tout en réfléchissant aux défis posés par le corpus holbachique ainsi qu’à l’apport possible de notre édition à l’étude de la pensée du baron et des Lumières radicales plus en général.
Que veulent les images de l’IA ?
Authors: Romele Alberto , Severo Marta
Published: May 2023

L’hypothèse de cet article est qu’il existe une difficulté intrinsèque à représenter visuellement l’intelligence artificielle (IA), en particulier pour un public non expert. Les magazines de vulgarisation scientifique répondent à ce défi de différentes manières. Dans la première partie, nous proposons une analyse sémiotique de la manière dont l’IA est représentée visuellement dans le Journal du CNRS et dans la revue Research*EU publiée par CORDIS, le service d’information sur la recherche et le développement de la Commission européenne. De cette analyse, nous extrayons une typologie des représentations visuelles de l’IA que nous examinons dans la deuxième partie. Nous distinguons notamment trois manières de représenter visuellement l’IA, dont aucune ne semble satisfaire le besoin de représenter la « chose en soi » : (1) selon l’algorithme, (2) selon la technologie dans laquelle l’algorithme est censé être intégré, et (3) selon les imaginaires. Dans la troisième partie, nous présentons un argumentaire épistémologique et éthique par rapport à ces représentations. Contrairement à un biais référentialiste très courant dans la communication scientifique, et qui conduit à préférer (1) à (2) et (2) à (3), nous incitons à la « pensivité » des images. Dans la conclusion, nous soutenons que le problème des images de l’IA n’est pas qu’elles ne font pas référence aux « choses mêmes », mais qu’elles ne favorisent aucune forme de débat et l’anesthésient plutôt.
Ce que les machines ont vu et que nous ne savons pas encore
Authors: di Lenardo Isabella , Kaplan Frédéric
Published: May 2023

Cet article conceptualise l’idée qu’il existe une « matière noire » composée des structurations latentes identifiées par le regard machinique sur de grandes collections photographiques patrimoniales. Les campagnes photographiques de l’histoire de l’art, au xx e  siècle, avaient pour ambition implicite de transformer toutes les œuvres d’art en documents plus facilement étudiables. Au fil du temps, la création de ces collections visuelles a permis de produire un corpus d’informations potentiellement plus dense et plus riche que ce que ses créateurs avaient initialement imaginé. En effet, la conversion numérique de ces immenses corpus visuels permet aujourd’hui de réanalyser ces images avec des techniques de vision par ordinateur, l’intelligence artificielle ouvrant ainsi la voie à des perspectives d’études bien différentes de celles envisageables au siècle dernier. Nous pourrions ainsi dire qu’il y a dans ces images un immense potentiel latent de connaissance, un réseau dense de relations qui n’a pas encore été mis en lumière. Qu’est-ce que les machines ont vu ou vont pouvoir voir dans ces collections d’images que l’homme n’a pas encore identifié ? Quelle étendue la connaissance visuelle de l’homme couvre-t-elle par rapport à ce que la machine a pu analyser ? Les nouvelles techniques d’indexation des images et des motifs qui les constituent nous rapprochent d’une révolution copernicienne du visuel dans laquelle l’homme peut, grâce à la machine-prothèse, analyser beaucoup plus d’images qu’il ne pouvait le faire par une simple activité mnémonique et sélectionner des perspectives spécifiques en comparant des ensembles de motifs les uns par rapport aux autres. Cette vision augmentée est fondée sur une pré-analyse conduite par la machine sur l’ensemble de ces corpus visuels, un entraînement qui permet de retrouver la structure sous-jacente du système d’images. La vision humaine est ainsi étendue par le regard artificiel préalable de la machine. Pour comprendre les enjeux de cette nouvelle alliance, il faut étudier la nature de ce regard artificiel, comprendre son potentiel pour découvrir des structures jusqu’à présent inconnues et anticiper les nouvelles formes de connaissances humaines auxquelles il pourra donner naissance. L’enjeu sera donc, pour les prochaines années, de comprendre ce que les machines ont vu et que nous ne savons pas encore.
Comparative Analysis of Different Implant Impression Techniques: An In vitro Study
Authors: Agnihotri Radhika R , Naik Saloni , Vaishnav Kalpesh , Shah Dipti S , Joshi Ravi , Bhatt Miloni
Published: May 2023

Introduction:

Dental implants have emerged as the treatment of choice for restoring missing teeth in situations that require functional and aesthetic replacements. The aim of the study was to assess the dimensional accuracy of (1) the resultant casts made from different impression techniques for implants, (2) implant impressions using two types of splinting material for open tray technique, auto-polymerising acrylic resin and light-cure acrylic resin and impression techniques, including non-sectioning and sectioning and rejoining with the same splinting material.

Materials and Methods:

The present study was conducted to compare the accuracy of direct splinted implant impression techniques. There were four impression techniques selected: (1) direct impression technique with autopolymerising acrylic resin splint, (2) direct impression technique with autopolymerising acrylic resin splint sectioned 17 min after setting and welded with the same resin, (3) direct impression technique with light-cure acrylic resin splint and (4) direct impression technique with light-cure acrylic resin splint sectioned and welded with the same resin.

Results:

Comparison within the four impression groups with respect to distances X and Y with a master model by Tukey’s post-hoc procedures shows a statistically significant difference only for Group 1, showing P < 0.05.

Conclusion:

There is a significant difference in the accuracy of the direct splinted implant impression technique with auto-polymerising acrylic resin without sectioning. Sectioning the auto-polymerising acrylic resin splint after 17 min and rejoining before impression making markedly increase the accuracy of implant impression. Splinting with light-cure acrylic resin shows a more accurate impression than the splint with auto-polymerising acrylic resin.
Enzalutamide and olaparib synergistically suppress castration-resistant prostate cancer progression by promoting apoptosis through inhibiting nonhomologous end joining pathway
Authors: Dong Hui-Yu , Zang Pan , Bao Mei-Ling , Zhou Tian-Ren , Ni Chen-Bo , Ding Lei , Zhao Xu-Song , Li Jie , Liang Chao
Published: May 2023

Recent studies revealed the relationship among homologous recombination repair (HRR), androgen receptor (AR), and poly(adenosine diphosphate-ribose) polymerase (PARP); however, the synergy between anti-androgen enzalutamide (ENZ) and PARP inhibitor olaparib (OLA) remains unclear. Here, we showed that the synergistic effect of ENZ and OLA significantly reduced proliferation and induced apoptosis in AR-positive prostate cancer cell lines. Next-generation sequencing followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed the significant effects of ENZ plus OLA on nonhomologous end joining (NHEJ) and apoptosis pathways. ENZ combined with OLA synergistically inhibited the NHEJ pathway by repressing DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and X-ray repair cross complementing 4 (XRCC4). Moreover, our data showed that ENZ could enhance the response of prostate cancer cells to the combination therapy by reversing the anti-apoptotic effect of OLA through the downregulation of anti-apoptotic gene insulin-like growth factor 1 receptor (IGF1R) and the upregulation of pro-apoptotic gene death-associated protein kinase 1 (DAPK1). Collectively, our results suggested that ENZ combined with OLA can promote prostate cancer cell apoptosis by multiple pathways other than inducing HRR defects, providing evidence for the combined use of ENZ and OLA in prostate cancer regardless of HRR gene mutation status.
Anxiety and Depression after Traumatic Open-Globe Injury
Authors: Hellman Justin , Mahmood Bilawal , Lin Lily Koo
Published: May 2023

Introduction:

This cross-sectional interview-based study aimed to assess the prevalence and severity of probable anxiety and depression in patients with traumatic open-globe injury and to identify factors associated with anxiety and depression following open-globe injury.

Methods:

Two hundred and twenty-five patients with open-globe injury were identified at the UC Davis Medical Center between 2008 and 2019. Prisoners and patients under 18 at the time of recruitment were excluded from the study. One hundred and twenty-four patients provided consent to participate in the study, which involved a phone interview and chart review. The interview consisted of a section on sociodemographic data and potential associations followed by the Hospital Anxiety and Depression Scale, a standardized 14-question survey that has been validated in previous studies as an excellent predictor of anxiety and depression. A score of 8 for anxiety or depression was considered a positive test, and patients with a positive test in either category were advised to seek further evaluation with their primary care doctors. The prevalence of probable anxiety and depression was calculated, and linear regression was used to identify factors associated with anxiety and depression.

Results:

The average age was 50.5 ± 19.2, and 75.8% of patients were male. The anxiety score was positive in 37.9% of patients and the depression score was positive in 28.2%. The mean anxiety and depression scores were 6.3 ± 4.7 and 5.5 ± 4.8, respectively. The P value of the linear regressions for anxiety score and depression score were both < 0.001, with R
2 = 0.429 and 0.363, respectively. Younger age (P = 0.002) and unemployment at the time of the interview (P = 0.038) were associated with higher anxiety scores. Patients who were bothered by the appearance of their injured eye had higher anxiety scores (P < 0.001) and depression scores (P < 0.001). Patients without a high school diploma had higher depression scores (P < 0.001). Gender, enucleation status, number of people in support network, use of a prosthetic or scleral shell, final logMAR visual acuity, marital status, months since the initial injury, and presence of an intraocular foreign body were not significantly associated with anxiety or depression scores.

Conclusions:

Traumatic open-globe injury is associated with a high prevalence of probable anxiety and depression. Dissatisfaction with the appearance of the injured eye was associated with higher anxiety and depression scores. Younger age and unemployment were associated with increased anxiety scores, and lack of a high school diploma was associated with higher depression scores.
An Observational Study of Association of Clinicopathological Stage and Ki-67, P53, Human Epidermal Growth Factor Receptor 2/neu, Estrogen Receptor, and Progesterone Receptor Status in Breast Cancer
Authors: Sharma Rachin , Karim Tanweer , Patel Gaurav , Sharma Tushar , Rohitaj Rahul , Dua Manisha
Published: May 2023

ABSTRACT

Objectives:

The objective was to study the association between the clinicopathological stage of breast cancer and lymph node (LN) involvement with respect to Ki-67, P53, human epidermal growth factor receptor (HER2/neu), estrogen receptor (ER), and progesterone receptor (PR) status.

Methods:

This observational cross-sectional study, conducted in a tertiary care hospital, included 100 adult female patients with operable breast carcinoma. The histopathological investigations, including histopathological typing and immunohistochemistry (IHC) (ER, PR, HER2/neu, Ki-67, and p53), were done. For IHC, a cutoff of 10% stained cells or more was considered positive for ER, PR, p53, and HER2/neu, and a cutoff of >14% stained cells was considered positive for Ki-67 expression. The interrelation of markers with clinical stage and LN involvement was evaluated.

Results:

ER, PR, and HER2/neu status were positive in 56%, 42%, and 22% of cases. Ki-67 ≥14% was present in 94% of cases. P53 was positive in 14% of cases. P53 and Ki-67 showed a significant association with tumor (T), nodes (N), and metastases (M) staging. As for the IHC of axillary LN s, only Ki-67 increased expression (≥14%) showed a significant association with P = 0.01. For the clinical staging, no markers among ER, PR, HER2/neu, Ki-67, and p53 showed a significant association.

Conclusion:

To conclude, p53 increased mutation and Ki-67 expression hold a significant association with the increasing stage of breast cancer and axillary lymphadenopathy.
Use of Virgin Sesame Oil in Addition to Soda Saline Mouthwash for the Prevention of Radiation induced Oral Mucositis in Head and Neck Cancer Patients: A Prospective Study
Authors: Das Tapashi , Kalita Apurba Kumar , Bhattacharyya Mouchumee , Nath Jyotiman , Yanthan Yanpothung , Sarma Biswajit , Das Ankita , Neog Moniprom , Das Abhinandan , Sonar Mongal
Published: May 2023

ABSTRACT

Background:

As illustrated by the magic words “Open, sesame” from the Arabian night stories meaning “unlocking of treasures,” the use and benefits of sesame oil have been mentioned in ancient literature of Egypt, Greece, and China, Ayurveda of India, and various prospective studies. Hence, it is anticipated that its antioxidant, anti-inflammatory, and antimicrobial effect might be effective for preventing chemoradiotherapy-induced acute oral mucositis (OM). Furthermore, soda-saline mouthwash (SSM) potentiates its impact through saponification.

Materials and Methods:

It was a single-arm, open-label, prospective study conducted in a tertiary care hospital in Northeast India. Sixty-six patients with head-and-neck squamous cell carcinoma planned for definitive chemoradiation were enrolled in the study. The patients rinsed their mouths with 2 tablespoons of virgin sesame oil six times/day and SSM 15 ml ten times/day from the 1st day of radiotherapy (RT) until 6-week post-RT. OM was graded using Radiation Therapy Oncology Group criteria.

Results:

Out of finally analyzed 58 patients, most were male with a mean age of 55 years. The mean time of development of Grade I and Grade II OM was 4.71 ± 0.92 and 5.86 ± 0.80 weeks, respectively. The incidence of grade ≥3 OM was 12.1%.

Conclusion:

Sesame oil + SSM remarkably helped in delaying the onset and severity of mucositis as compared to other studies. It is simple to practice with good compliance and no side effects. Additional replication studies, including randomized studies comparing this with other mouthwashes, using large sample sizes are required for its routine use.
Analysis of Different Evaluation Indexes for Postoperative Brain Cancer Radiation Therapy Plans: Conformity Index, Homogeneity Index, and Total Coverage Index
Authors: Rather Sajad Ahmad , Banday Muddasir Sharief , Mufti Samina , Sofi Mustaq Ahmad , Baba Misbha Hamid
Published: May 2023

ABSTRACT

Objective:

This study analyzed different planning target dose–volume evaluation parameters, target mean dose, homogeneity index (HI), conformity index (CI), and Target Coverage Index (TCI) for different conformal techniques. The purpose of this article was to analyze these three parameters in the assessment of the treatment plans in ten patients undergoing postoperative conformal radiotherapy treatment.

Materials and Methods:

We retrospectively evaluated that the treatment plans of ten patients with a prescribed dose was 60 Gy delivered at 2.0 Gy per fraction using 6 MV photon energy. The dosimetric comparison was done by performing two plans for the same patient; prescription dose and normal tissue constraints were identical for both plans. A total of ten patients underwent computed tomography treatment planning in conjunction with magnetic resonance imaging fusion. Prescription dose and normal tissue constraints were identical for both conformal plans. The irradiated patients were retrieved and replanned with three-dimensional conformal radiation therapy (3DCRT) techniques, and a dosimetric comparison was done by performing two plans for the same patient.

Results:

The Student’s t-test was used to perform statistical analysis to determine the differences between the dose–volume constraints used for planning. The cumulative dose–volume histogram of target volumes (TVs), target coverage, target homogeneity, target conformity, and normal tissue sparing with two different conformal planning was compared. The intensity-modulated radiation therapy (IMRT) plan yielded superior target coverage as compared with the 3D-CRT plan. Specifically, minimum and mean planning TV cone-down doses were 46.80 ± 4.16 Gy and 60.72 ± 1.00 Gy for IMRT and 49.06 ± 4.98 Gy and 61.04 ± 1.15 Gy for 3D-CRT P < 0.519, respectively. The CI was approximately equal in both the modalities with an average value of 0.962 ± 0.041 in IMRT compared to 0.969 ± 0.039 in 3DCRT (P < 0.481). The average HI in IMRT was 0.187 ± 0.176 and 0.099 ± 0.0500 in 3DCRT (P < 0.165). Therefore, IMRT achieved an improvement in HI. The target coverage index (TCI) in IMRT was 0.7213 ± 0.2050 and 0.5970 ± 0.194 in 3DCRT. Statistical analysis was performed to determine the differences.

Conclusions:

These indexes can all be objective tools for the evaluation of plan quality. The IMRT plan yielded superior target coverage and reduced radiation dose to the brain, brainstem, and optic chiasm. With the availability of new cancer imaging tools and more effective systemic agents, IMRT may be used to intensify tumor doses when minimizing toxicity, therefore potentially improving outcomes in patients.
Comparison between En bloc Resection and Conventional Resection of Bladder Tumor in Perioperative and Oncological Outcomes
Authors: Chiang Ping-Chia , Chiang Po-Hui , Luo Hao-Lun
Published: May 2023

Purpose:

Conventional transurethral resection of bladder tumors (cTURBT) has been the main technique for treating visible bladder tumor for decades. However, the reported rate of detrusor muscle presence in cTURBT specimen was lower than 80%, which is associated with imprecise staging and poor prognosis. Here, we present a retrospective analysis to compare the detrusor muscle detection rate and outcomes between en bloc resection of bladder tumor (ERBT) and cTURBT.

Materials and Methods:

Between January 2016 and December 2019, a total of 150 procedures performed by single surgeon in single institute were reviewed in this study. Of these procedures, 41 (27.3%) were ERBT and 109 (72.6%) were cTURBT. The two techniques were compared for pathological detrusor muscle detection, history of upper tract urothelial cancer, number of tumor lesions, histopathological grading and staging, time of operation, and time of catheterization and hospitalization.

Results:

The muscularis propria detection rate was statistically significantly higher in the ERBT group than in the cTURBT group (82.9% vs. 43.1%, P < 0.0001). The multivariate analysis showed resection method as an independent factor of detrusor muscle presentation (P < 0.0001). The mean Foley catheter indwelling and hospitalization days were longer in the ERBT group but were only 1 day longer than in the cTURBT group.

Conclusion:

ERBT significantly increases the muscularis propria detection rate than cTURBT. ERBT can provide more accurate cancer staging and contribute to proper decision-making. This study strengthens ERBT as a feasible and promising management of bladder cancer.
Quality Assessment of Dried Striped Dwarf Catfish, Mystus vittatus in the North-Eastern Region of Bangladesh
Authors: Hasan Md. Mehedy , Islam Md. Jakiul , Sayeed Md. Abu , Chowdhury Md. Atick , Bapary Mohammad Abu Jafor , Hussain Md. Ashraf
Published: May 2023

Dried fish is a popular and in-demand fish food item in Bangladesh, and it is regarded to be the most cost-effective form of nutritional protein, which helps to alleviate malnutrition among the disadvantaged people. A consumer survey reported a slew of concerns regarding the physical, visual, and organoleptic aspects of market available sun-dried fish. The current study evaluated the organoleptic, nutritional, and microbiological quality of dried striped dwarf catfish, Mystus vittatus, which is one of the most popular dried fish in Bangladesh. To highlight the quality disparities among the samples, an experimental sample was made in the laboratory with the utmost hygiene and sanitation. Experimental samples had the highest features score than marketed ones, according to organoleptic analysis. Except for moisture and ash content, the experimental sample had greater mean lipid, protein, crude fiber, and nitrogen-free-extract (NFE) values. The mean (±SD) moisture content of the experimental, drying yard and market sample were 19.82±1.7, 21.44±2.7 and 24.3±1.4%; lipid content were 12.30±2.12, 10.54±1.76 and 9.04±2.41%; protein content were 43.01±.10, 41.74±.79 and 39.67±3.18%; ash content were 16.11±1.70, 17.91±3.70 and 20.77±3.24%; crude fiber content were 1.78±.08, 1.56±.08 and 1.54±.13% and NFE content were 7.01±1.08, 6.80±.77 and 4.67±1.01%, respectively. The mean Total Plate Count (TPC) of dried M. vittatus from the experiment, drying yard, and market samples, respectively, was 4.51±0.11, 5.33±0.25, and 6.39±0.18 log cfu g-1. The results show that commercially manufactured dried striped dwarf catfish has low organoleptic, nutritional, and microbiological quality. Commercially manufactured dried fish requires improved hygiene and good manufacturing practices (GMPs) to ensure consumer safety and health.
Ramification filtration and differential forms
Authors: Abrashkin Viktor Aleksandrovich
Published: May 2023

Let $L$ be a complete discrete valuation field of prime characteristic $p$ with finite residue field. Denote by $\Gamma_{L}^{(v)}$ the ramification subgroups of $\Gamma_{L}=\operatorname{Gal}(L^{\mathrm{sep}}/L)$. We consider the category $\operatorname{M\Gamma}_{L}^{\mathrm{Lie}}$ of finite $\mathbb{Z}_p[\Gamma_{L}]$-modules $H$, satisfying some additional (Lie)-condition on the image of $\Gamma_L$ in $\operatorname{Aut}_{\mathbb{Z}_p}H$. In the paper it is proved that all information about the images of the groups $\Gamma_L^{(v)}$ in $\operatorname{Aut}_{\mathbb{Z}_p}H$ can be explicitly extracted from some differential forms $\widetilde{\Omega} [N]$ on the Fontaine etale $\phi $-module $M(H)$ associated with $H$. The forms $\widetilde{\Omega}[N]$ are completely determined by a canonical connection $\nabla $ on $M(H)$. In the case of fields $L$ of mixed characteristic, which contain a primitive $p$th root of unity, we show that a similar problem for $\mathbb{F}_p[\Gamma_L]$-modules also admits a solution. In this case we use the field-of-norms functor to construct the corresponding $\phi $-module together with the action of the Galois group of a cyclic extension $L_1$ of $L$ of degree $p$. Then our solution involves the characteristic $p$ part (provided by the field-of-norms functor) and the condition for a "good" lift of a generator of $\operatorname{Gal}(L_1/L)$. Apart from the above differential forms the statement of this condition uses the power series coming from the $p$-adic period of the formal group $\mathbb{G}_m$.
Bibliography: 21 titles.
An Aerodynamic Equation of State—Part I: Introduction and Aerospace
Applications
Authors: Burgers Phillip
Published: May 2023

In subsonic aircraft design, the aerodynamic performance of aircraft is compared
meaningfully at a system level by evaluating their range and
endurance, but cannot do so at an aerodynamic level when using
lift and drag coefficients, CL
 and CD
, as these often result in misleading results for different wing
reference areas. This Part I of the article (i) illustrates these shortcomings,
(ii) introduces a dimensionless number quantifying the induced drag of aircraft,
and (iii) proposes an aerodynamic equation of state for lift,
drag, and induced drag and applies it to evaluate the aerodynamics of the canard
aircraft, the dual rotors of the hovering Ingenuity Mars
helicopter, and the composite lifting system (wing plus cylinders in Magnus
effect) of a YOV-10 Bronco. Part II of this article applies
this aerodynamic equation of state to the flapping flight of hovering and
forward-flying insects. Part III applies the aerodynamic equation of state to
some well-trodden cases in fluid mechanics found in fluid-mechanics
textbooks.
An Aerodynamic Equation of State—Part II: Applications to Flapping
Flight
Authors: Burgers Phillip
Published: May 2023

Part I introduced the aerodynamic equation of state. This Part II introduces the
aerodynamic equation of state for lift and induced drag of flapping wings and
applies it to a hovering and forward-flying bumblebee and a mosquito. Two- and
three-dimensional graphical representations of the state space are introduced
and explored for engineered subsonic flyers, biological fliers, and sports
balls.
Experimental Evaluation of Pilot and Main Injection Strategies on
Gasoline Compression Ignition Engine—Part 1: Combustion
Characteristics
Authors: Agarwal Avinash Kumar , Solanki Vishnu Singh , Krishnamoorthi M.
Published: May 2023

Climate change and stringent emission regulations have become major challenges
for the automotive sector, prompting researchers to investigate advanced
combustion technologies. Gasoline compression ignition (GCI) technology has
emerged as a potential solution, delivering higher brake thermal efficiency with
ultra-low nitrogen oxides (NOx) and particulate emissions. Combustion stability
and controls are some of the significant challenges associated with GCI. This
study investigates the combustion characteristics of a two-cylinder diesel
engine in GCI mode. GCI experiments were performed using a low-octane fuel
prepared by blending 80% (v/v) gasoline and 20% (v/v) diesel (G80). Baseline
experiments were conducted in conventional diesel combustion (CDC) mode. These
experiments investigated the effects of double pilot injection, first pilot fuel
ratio, and the start of main fuel injection timing (10–8°CA before top dead
center, bTDC). The results indicated that the GCI mode produced significantly
lower (~10%) in-cylinder pressure than the CDC mode. Higher pilot fuel
proportions exhibited a lower heat release rate (HRR) at low loads. Retarded
main injection showed a lower heat release in the premixed combustion phase than
the advanced main injection case at all loads. In addition, retarded main
injection timing showed retarded start of combustion (SoC) and end of combustion
(EoC). GCI mode exhibited higher cyclic variations than baseline CDC mode, which
need to be addressed.
Several Roman domination graph invariants on Kneser graphs
Authors: Zec Tatjana , Grbić Milana
Published: May 2023

This paper considers the following three Roman domination graph invariants on
Kneser graphs:
Roman domination, total Roman domination, and signed Roman domination.
For Kneser graph $K_{n,k}$, we present exact values for Roman domination
number $\gamma_{R}(K_{n,k})$ and total Roman domination number
$\gamma_{tR}(K_{n,k})$ proving that for $n\geqslant k(k+1)$,
$\gamma_{R}(K_{n,k}) =\gamma_{tR}(K_{n,k}) = 2(k+1)$. For signed Roman
domination number $\gamma_{sR}(K_{n,k})$, the new lower and upper bounds for
$K_{n,2}$ are provided: we prove that for $n\geqslant 12$, the lower bound is
equal to 2, while the upper bound depends on the parity of $n$ and is equal to
3 if $n$ is odd, and equal to $5$ if $n$ is even. For graphs of smaller
dimensions, exact values are found by applying exact methods from literature.
Redesigning an Organization of a Construction Company
Authors: Widiaputra Andyka Bayu
Published: May 2023

The early years of company X were successful, and the company was able to grow into the successful enterprise that it is today. On the other hand, as the company grows, the challenges it faces become more complex, which has led to inefficient operations for the company. The problems stem from company X ineffective business organization as well as its inability to adapt to changing times and circumstances. The problems are showing up in their financial performance, which has shown a drop in revenue, which has stopped the company from growing. Internal observation will be used in this study to help figure out what the real problems are and what company X should do next. The 7S McKinsey model will be used to figure out what needs to be changed in terms of reorganization. We will look at the organization's strategy, structure, system, style, people, skills, and shared values. Seven company X employees were interviewed, and after the interview results are coded it was shown that their desire for the 7S is not align with the company's current state, which shows that the company needs to change. Lewin's Three Stages of Change model is used to redesign organizations once the change that was wanted has taken place. It will be used to figure out what steps company X should take to change their organization in a way that will work, starting with unfreezing, then making changes, and ending with freezing the transformation of the organization
Analysis of Attacks and Cybersecurity in the Health Sector During a Pandemic COVID-19: Scoping Review
Authors: Awaludin Awaludin , Sulistyadi Wahyu , Chandra Alexandra Francesca
Published: May 2023

COVID-19 as a global pandemic in March 2020 medical personnel and all types of patients with various chronic conditions is undeniably the largest group of users of digital technology during the pandemic. Increased exposure and massive use of the internet is certainly a potential security threat in itself, especially in the threat of cyber-attacks. The purpose of this study is to analyze cyber-attacks and security in the health sector during the COVID 19 pandemic. The scoping review was conducted by searching two main scientific databases (PubMed and Scopus) using the search formula “COVID 19, Pandemic and cyber-attack, cyber security.” Reports, news articles or websites are also included if they are directly related to previously published work, or if they are the only sources available at the time of writing. Only articles in English published in the last decade are included (i.e., 2009-2020) to focus on current problems, challenges, and solutions. In total, 34 papers were included in the review. We found information technology in the health sector that was used during the COVID 19 pandemic. The COVID-19 pandemic situation is a type of non-traditional security that has a broad impact on various aspects of human life, including the health sector. At a time when many countries have responded to the pandemic situation with various restrictive policies to the prohibition of mobilization, people are adapting by shifting to a new landscape of activity. The cyber world is then used by the community to continue to run productivity. This then has implications for the increase in internet users globally, including Indonesia. Some of the cyberattacks include the practice of phishing emails targeting individual and corporate entities, ransomware targeting healthcare facilities and companies. Further research is needed, especially exploring research on cyber-attacks during a pandemic from the point of view of implementation of cyber security.
Legal Analysis of the Effective Use of School Operational Assistance Funds in North Halmahera District
Authors: Wahyuni Rina , Alting Husen , Suwarti Suwarti
Published: May 2023

Regulation of the Minister of Education and Culture Number 6 of 2021 Concerning the Technical Guidelines for Regular School Operational Assistance states that the purpose of providing BOS Funds is to help with school operational costs, increase flexibility and quality of learning for students. The government hopes that every poor citizen can get an education and experience a better teaching and learning process. school operations in North Halmahera Regency. This study uses qualitative research. The population study was all schools in West Kao District, North Halmahera Regency with a sample of 11 schools. This research was conducted from June to August 2022. The research instruments were interviews and observations. The results showed that the use of BOS funds had not been effective so that the quality of education was still relatively low.
The Role of Job Satisfaction Mediating Organizational Commitment Against Employee Performance (Study on Employees of PT BPR Gunung Rizki Semarang)
Authors: Noor Ridwan Alfian , Priyono Bambang Suko
Published: May 2023

The performance of PT. BPR Gunung Rizki Semarang branch office in 2017-2018 has decreased. This phenomenon was found in the object of research when the preliminary survey was conducted. The results of theoretical studies of factors that can explain performance show results that are still different. Departing from these empirical and theoretical phenomena, this study is aimed at analyzing the effect of Organizational Commitment and Personality on Performance by Mediating Job Satisfaction on employees of PT. BPR Mount Rizki Semarang. The study aims to examine the role of job satisfaction mediating organizational commitment against employee performance. The empirical model developed in this study consists of three research variables, namely organizational commitment and job satisfaction which are thought to explain performance. Research data was obtained through interviews using questionnaires to 124 employee respondents at PT. BPR Mount Rizki Semarang. The collected data were analyzed using multiple regression tests. Statistical test results show that organizational commitment has no significant effect on job satisfaction. While on performance, organizational commitment has a positive effect while job satisfaction has a negative effect.