bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustaining the Quality of Life for University Employees with Obesity Using Mindfulness Activities and Work Engagement: A Quasi-Experimental Design
Authors: Kadir Nor Ba’yah Abdul , Helma Rusyda , Ismail Wan Nur Khairunnisa , Abdul Jalil Siti Jamiaah , Abdullah Nurul-Azza , Che Kasim Arena , Mohd. Hoesni Suzana , Manaf Mohd Rizal Abdul
Published: February 2022

Using an e-calendar, a web-based intervention program, informal mindfulness activities, and work engagement, this study evaluated the sustainability of the quality of life for staff with obesity at a Malaysian public university. The participants were identified through the human resources department of the university. The inclusion criteria required an age of 20–59 years and BMI ≥ 25. The exclusion criteria were pregnancy, the use of weight loss pills or supplements that can influence weight, chronic illness, and the use of medication that requires physician monitoring. Thirty-one university staff were assessed for quality of life using a within-subject repeated-measures design. The participants were asked to use the study website for 10 to 15 min/day for 36 weeks. Data was captured by a pretest, posttest, and two follow-up surveys. The results showed an increase in the posttest mean scores for all domains representing the quality of life. As expected, three domains increased at follow-up 1 and were maintained at follow-up 2. This suggests that informal mindfulness practices and work engagement using an e-calendar are practical means to increase and sustain the quality of life of employees. In conclusion, the quality of life among university staff with obesity can be improved using informal mindfulness activities and work engagement, and an e-calendar is another alternative method of practicing mindfulness at home and at the workplace. The implications of this study are also discussed.
How Green Are the National Hydrogen Strategies?
Authors: Cheng Wenting , Lee Sora
Published: February 2022

Since Japan promulgated the world’s first national hydrogen strategy in 2017, 28 national (or regional, in the case of the EU) hydrogen strategies have been issued by major world economies. As carbon emissions vary with different types of hydrogen, and only green hydrogen produced from renewable energy can be zero-emissions fuel, this paper interrogates the commitment of the national hydrogen strategies to achieve decarbonization objectives, focusing on the question “how green are the national hydrogen strategies?” We create a typology of regulatory stringency for green hydrogen in national hydrogen strategies, analyzing the text of these strategies and their supporting policies, and evaluating their regulatory stringency toward decarbonization. Our typology includes four parameters, fossilfuel penalties, hydrogen certifications, innovation enablement, and the temporal dimension of coal phasing out. Following the typology, we categorize the national hydrogen strategies into three groups: zero regulatory stringency, scale first and clean later, and green hydrogen now. We find that most national strategies are of the type “scale first and clean later”, with one or more regulatory measures in place. This article identifies further challenges to enhancing regulatory stringency for green hydrogen at both national and international levels.
Greenhouse Gas Fluxes from Selected Soil Fertility Management Practices in Humic Nitisols of Upper Eastern Kenya
Authors: Githongo Miriam W , Musafiri Collins M. , Macharia Joseph M. , Kiboi Milka N. , Fliessbach Andreas , Muriuki Anne , Ngetich Felix K.
Published: February 2022

We quantified the soil carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) fluxes of five soil fertility management practices (inorganic fertilizer (Mf), maize residue + inorganic fertilizer (RMf), maize residue + inorganic fertilizer + goat manure (RMfM), maize residue + tithonia diversifolia + goat manure (RTiM), and a control (CtC)) in Kenya’s central highlands using a static chamber method from March 2019 to March 2020. The cumulative annual soil CH4 uptake ranged from −1.07 to −0.64 kg CH4-C ha−1 yr−1, CO2 emissions from 4.59 to 9.01 Mg CO2-C ha−1 yr−1, and N2O fluxes from 104 to 279 g N2O-N ha−1 yr−1. The RTiM produced the highest CO2 emissions (9.01 Mg CO2-C ha−1 yr−1), carbon sequestration (3.99 Mg CO2-eq ha−1), yield-scaled N2O emissions (YSE) (0.043 g N2O-N kg−1 grain yield), the lowest net global warming potential (net GWP) (−14.7 Mg CO2-eq ha−1) and greenhouse gas intensities (GHGI) (−2.81 Kg CO2-eq kg−1 grain yield). We observed average maize grain yields of 7.98 Mg ha−1 yr−1 under RMfM treatment. Integrating inorganic fertilizer and maize residue retention resulted in low emissions, increased soil organic carbon sequestration, and high maize yields.
Quasi-Analytical Solution of Optimum and Maximum Depth of Transverse V-Groove for Drag Reduction at Different Reynolds Numbers
Authors: Li Zhiping , He Long , Zheng Yixuan
Published: February 2022

Reducing the skin-friction drag of a vehicle is an important way to reduce carbon emissions. Previous studies have investigated the drag reduction mechanisms of transverse grooves. However, it is more practical to investigate which groove geometry is optimal at different inflow conditions for engineering. The purpose of this paper is to establish the physical model describing the relationship between the dimensionless depth (H+=Huτ/υ) of the transverse groove, the dimensionless inflow velocity (U∞+=U∞/uτ), and the drag reduction rate (η) to quasi-analytically solve the optimal and maximum transverse groove depth according to the Reynolds numbers. Firstly, we use the LES with the dynamic subgrid model to investigate the drag reduction characteristics of transverse V-grooves with different depths (h = 0.05~0.9 mm) at different Reynolds numbers (1.09×104~5.44×105) and find that H+ and U∞+ affect the magnitude of slip velocity (Us+), thus driving the variation of the viscous drag reduction rate (ην) and the increased rate of pressure drag (ηp). Moreover, the relationship between Us+, ην, and ηp is established based on the slip theory and the law of pressure distribution. Finally, the quasi-analytical solutions for the optimal and maximum depths are solved by adjusting Us+ to balance the cost (ηp) and benefit (ην). This solution is in good agreement with the present numerical simulations and previous experimental results.
Measuring Bank Systemic Risk in China: A Network Model Analysis
Authors: Zou Jin , Fu Xu , Yang Jun , Gong Chi
Published: February 2022

Correlation networks and risk spillovers within financial institutions contribute to the generation and dissemination of systemic risk. In this paper, a risk correlation network is constructed among Chinese banks employing the maximum entropy method, which simulates the individual risks of banks in the presence of exogenous shocks, the contagious risks, and total systemic risk through the effect of network spillovers, and analyzes its influencing factors. The results show that there is an increasingly rising trend in the overall systemic risk of China’s banking industry, and that the value of systemic risk is relatively large. From the perspective of the composition of banking systemic risk, individual risk accounts for a large proportion, about 70%, which is the main source of banking systemic risk, among which China’s state-owned commercial banks are the largest source. The contagious risk of banks accounts for about 30%. Furthermore, the contagious risk contribution of various banks is basically negatively correlated with their scale. The smallest urban commercial bank in the banking industry contributes at least 50% of the contagion risk, while the state-owned commercial bank, which accounts for about 40% of the total assets of the banking industry, only contributes less than 30% of the contagion risk.
Ex Vivo Model to Assess the Exposure of Patients to Plasticizers from Medical Devices during Pre-CAR-T Cells’ Apheresis
Authors: Lautraite Raphaëlle , Bernard Lise , Halle Pascale , Chennell Philip , Le Basle Yoann , Kanold Justyna , Sautou Valérie
Published: February 2022

Background: The treatment of relapsed or refractory leukemia remains a major problem. Among the new therapeutic approaches, the use of modified T lymphocytes, called chimeric antigen receptor T cells (CAR-T cells), seems promising. The first step of their preparation is leukapheresis, which involves the collection of mononuclear cells from the patient. This medical procedure requires numerous medical devices (MDs) made of plasticized polyvinylchloride (PVC). These compounds can leach out of the devices during contact with the patient’s blood. The aim of our study was to evaluate the migration of the plasticizers contained in the MD during a simulated pre-CAR-T cell leukapheresis procedure, and to measure the patient’s and their lymphocytes’ exposure to them. Methods: The qualitative and quantitative composition of the MD used for pre-CAR-T cell apheresis was determined by gas chromatography–mass spectrometry (GC–MS). Then, an ex vivo leukapheresis model using an ethanol/water simulant was performed to evaluate the plasticizers’ migration under simulated clinical conditions of pre-CAR-T cells’ cytapheresis. The plasticizers released into the simulant were quantified by GC–MS. Results: Diethylhexylphthalate (DEHP) was found in the apheresis kit, with amounts ranging from 25% to 59% (g/100 g of PVC). Bis(2-ethylhexyl) adipate was detected at trace levels. A total of 98.90 ± 11.42 mg of DEHP was released into the simulant, corresponding to an exposure dose of 1.4 mg/kg for a 70 kg patient. Conclusions: Patients undergoing a pre-CAR-T cell apheresis are mainly exposed to DEHP, which can impact their health because of its endocrine disruption effect, but could also lead to a decrease in CAR-T cells’ efficiency/quality.
Management of Double Sensitization to Vespids in Europe
Authors: Ruiz-Leon Berta , Serrano Pilar , Vidal Carmen , Moreno-Aguilar Carmen
Published: February 2022

Wasp allergy with a diagnostic profile of double sensitizations to vespid venom is a frequent clinical problem in areas where different genera of wasps are present. Identification of the insect responsible for serious reactions poses a diagnostic challenge as the only effective treatment to date is immunotherapy based on the specific venom. In southern Europe, the double sensitization to Vespula and Polistes venoms is highly frequent. It has been shown that the major allergenic proteins (Phospholipase A1 and Antigen 5) share sequences across the different genera and species, which would be the cause of cross-reactivity. Additionally, the minor allergens (Dipeptidyl-peptidases, Vitellogenins) have been found to share partial sequence identity. Furthermore, venom contains other homologous proteins whose allergenic nature still remains to be clarified. The traditional diagnostic tools available are insufficient to discriminate between allergy to Vespula and Polistes in a high number of cases. IgE inhibition is the technique that best identifies the cross-reactivity. When a double sensitization has indeed been shown to exist or great uncertainty surrounds the primary sensitization, therapy with two venoms is advisable to guarantee the safety of the patient. In this case, a strategy involving alternate administration that combines effectiveness with efficiency is possible.
Special Issue “Pediatric Viral Infection Long-Term Consequences”
Authors: Rowe Regina K. , Mohr Emma L.
Published: February 2022

This Special Issue was focused on advancing our understanding of the long-term consequences of pediatric viral infections [...]
High-Throughput Platform for Detection of Neutralizing Antibodies Using Flavivirus Reporter Replicon Particles
Authors: Lücke Arlen-Celina , vom Hemdt Anja , Wieseler Janett , Fischer Carlo , Feldmann Marie , Rothenfusser Simon , Drexler Jan Felix , Kümmerer Beate Mareike
Published: February 2022

Flavivirus outbreaks require fast and reliable diagnostics that can be easily adapted to newly emerging and re-emerging flaviviruses. Due to the serological cross-reactivity among flavivirus antibodies, neutralization tests (NT) are considered the gold standard for sero-diagnostics. Here, we first established wild-type single-round infectious virus replicon particles (VRPs) by packaging a yellow fever virus (YFV) replicon expressing Gaussia luciferase (Gluc) with YFV structural proteins in trans using a double subgenomic Sindbis virus (SINV) replicon. The latter expressed the YFV envelope proteins prME via the first SINV subgenomic promoter and the capsid protein via a second subgenomic SINV promoter. VRPs were produced upon co-electroporation of replicon and packaging RNA. Introduction of single restriction enzyme sites in the packaging construct flanking the prME sequence easily allowed to exchange the prME moiety resulting in chimeric VRPs that have the surface proteins of other flaviviruses including dengue virus 1–-4, Zika virus, West Nile virus, and tick-borne encephalitis virus. Besides comparing the YF-VRP based NT assay to a YF reporter virus NT assay, we analyzed the neutralization efficiencies of different human anti-flavivirus sera or a monoclonal antibody against all established VRPs. The assays were performed in a 96-well high-throughput format setting with Gluc as readout in comparison to classical plaque reduction NTs indicating that the VRP-based NT assays are suitable for high-throughput analyses of neutralizing flavivirus antibodies.
Safety, Immunogenicity and Lot-to-Lot Consistency of Sabin-Strain Inactivated Poliovirus Vaccine in 2-Month-Old Infants: A Double-Blind, Randomized Phase III Trial
Authors: Zheng Yan , Ying Zhifang , Zou Yanxiang , Zhu Taotao , Qian Dinggu , Han Weixiao , Jiang Ya , Jiang Zhiwei , Li Xingyan , Wang Jianfeng , Lei Jin , Xu Li , Jiang Deyu , Li Changgui , Liu Xiaoqiang
Published: February 2022

Background: The Sabin-strain-based inactivated poliovirus vaccine (sIPV) plays an important role in poliomyelitis eradication in developing countries. As part of the phase III clinical development program, this study aimed to evaluate the safety, immunogenicity and lot-to-lot consistency of the sIPV in 2-month-old infants. Method: We conducted a phase III, randomized, double-blind, positive-controlled trial in which 1300 healthy infants were randomly assigned to four groups in a 1:1:1:1 ratio to receive one of the three lots of the sIPV or the control IPV at 2, 3 and 4 months of age. Serum samples were collected before the first dose and 30 days after the third dose of vaccination to assess the immunogenicity. Solicited local and systemic reactions were recorded within 7 days and unsolicited adverse events within 30 days after each vaccination. Results: Of the 1300 randomized infants, 1190 infants completed the study and were included in the per-protocol population. The seroconversion rates in the three lots of the sIPV were 95.67%, 97.03% and 95.59%, respectively, for type 1; 94.33%, 93.73% and 92.88%, respectively, for type 2; and 98.67%, 99.67% and 99.32%, respectively, for type 3. The ratios of GMTs for poliovirus types 1, 2 and 3 of each pair of lots were all between 0.67 and 1.50, therefore meeting the predefined immunological equivalence criteria. For the seroconversion rate of poliovirus types 1, 2 and 3, the pooled sIPV group was non-inferior to the IPV group. The incidence of solicited and unsolicited adverse reactions (ARs) was similar in the pooled sIPV lots and the IPV group, and most of them were mild to moderate in severity. Non-vaccine-related serious adverse events (SAEs) were reported. Conclusions: Three consecutive lots of sIPV demonstrated robust and consistent immunogenicity. The safety and tolerability of the sIPV was acceptable and similar to that of the IPV.
Humoral and Cellular Responses to COVID-19 Vaccination Indicate the Need for Post-Vaccination Testing in Frail Population
Authors: Witkowski Wojciech , Gerlo Sarah , De Smet Evelien , Wejda Magdalena , Acar Delphine , Callens Steven , Heytens Stefan , Padalko Elizaveta , Vercruysse Hanne , Cools Piet , Vandekerckhove Linos
Published: February 2022

Despite the high efficacy of the BNT162b2 vaccine in the general population, data on its immunogenicity among frail elderly individuals are limited. Recently, levels of anti-SARS-CoV-2 spike IgG antibodies and serum neutralization titers were confirmed as good immune markers of protection against the virus, with evidence showing a reverse correlation between these two parameters and susceptibility to infection. Here we analyzed sera from 138 nursing home residents (median age of 88.9 years) and 312 nursing home staff (median age of 50.7 years) to determine the humoral response to two doses of the BNT162b2 vaccine, and found markedly decreased serum anti-spike antibody levels and neutralization titers in the nursing home resident (NHR) group, with over 11% non-responders compared to only 1.3% among the controls. Moreover, three months post-vaccination, a significant decrease in antibody titers was observed in COVID-19-naive nursing home residents. Subsequent flow cytometry and interferon gamma secretion analyses indicated that antibody non-responders among NHRs also failed to mount cellular responses. The presented data emphasize that additional measures are needed in the population of frail elderly individuals. Given the high proportion of non-responders among NHRs, continued monitoring should be considered in this group.
Assessment of Spatio-Temporal Variability of Faecal Pollution along Coastal Waters during and after Rainfall Events
Authors: Manini Elena , Baldrighi Elisa , Ricci Fabio , Grilli Federica , Giovannelli Donato , Intoccia Michele , Casabianca Silvia , Capellacci Samuela , Marinchel Nadia , Penna Pierluigi , Moro Fabrizio , Campanelli Alessandra , Cordone Angelina , Correggia Monica , Bastoni Deborah , Bolognini Luigi , Marini Mauro , Penna Antonella
Published: February 2022

More than 80% of wastewaters are discharged into rivers or seas, with a negative impact on water quality along the coast due to the presence of potential pathogens of faecal origin. Escherichia coli and enterococci are important indicators to assess, monitor, and predict microbial water quality in natural ecosystems. During rainfall events, the amount of wastewater delivered to rivers and coastal systems is increased dramatically. This study implements measures capable of monitoring the pathways of wastewater discharge to rivers and the transport of faecal bacteria to the coastal area during and following extreme rainfall events. Spatio-temporal variability of faecal microorganisms and their relationship with environmental variables and sewage outflow in an area located in the western Adriatic coast (Fano, Italy) was monitored. The daily monitoring during the rainy events was carried out for two summer seasons, for a total of five sampling periods. These results highlight that faecal microbial contaminations were related to rainy events with a high flow of wastewater, with recovery times for the microbiological indicators varying between 24 and 72 h and influenced by a dynamic dispersion. The positive correlation between ammonium and faecal bacteria at the Arzilla River and the consequences in seawater can provide a theoretical basis for controlling ammonium levels in rivers as a proxy to monitor the potential risk of bathing waters pathogen pollution.
Degradation Kinetics and Disinfection By-Product Formation of Iopromide during UV/Chlorination and UV/Persulfate Oxidation
Authors: Hu Chenyan , Wang Qiangbing , Lin Yi-Li , Zhu Yeye , Xiong Cun , Huang Dandan , Xu Ling
Published: February 2022

As the detection of micropollutants in various water resources is commonly reported, developing an efficient technology to remove them to maintain water safety has become a major focus in recent years. The degradation kinetics of iopromide, one of a group of iodinated X-ray contrast media (ICM), using advanced oxidation processes of ultraviolet/chlorination (UV/Cl2) and UV/persulfate (UV/PS) oxidation were investigated in this research. The results show that iopromide degradation fitted pseudo-first-order kinetics, and the rate constants were calculated as 2.20 (± 0.01) × 10−1 min−1 and 6.08 (± 0.10) × 10−2 min−1 in UV/Cl2 and UV/PS, respectively. In the two systems, the degradation rates were positively correlated with the initial concentrations of HOCl and PS, respectively. In the UV/Cl2 system, the degradation rate of iopromide reached a maximum at pH 7, while in the UV/PS system, pH had only a slight effect on the degradation rate. Chloride in water had a negligible effect on iopromide degradation, whereas bromide inhibited iopromide degradation in the UV/Cl2 system. The contributions of UV irradiation, •OH, and RCS to iopromide degradation during UV/Cl2 treatment were calculated as 20.8%, 54.1%, and 25.1%, respectively. One carbonated and three nitrogenated disinfection by-products (C-DBP (chloroform) and N-DBPs (dichloroacetonitrile, trichloronitromethane, and trichloroacetone)) were detected at relatively high levels, along with three emerging iodinated DBPs (dichloroiodomethane, monochlorodiiodomethane, and triiodomethane). More C- and N-DBPs were generated in the UV/Cl2 and UV/PS systems than in UV irradiation, while considerably higher I-DBPs were generated in UV irradiation than in the other two systems. Thus, it is essential to pay attention to DBP formation when UV/Cl2 or UV/PS is used to treat iopromide in water. In order to better control the generation of carcinogenic and toxic I-DBPs, Cl2 or PS combined with UV should be adopted for iopromide degradation, instead of UV alone, for providing safe drinking water to the public.
Investigation of clinical and epidemiological features of Opisthorchis felineus invasion in Voronezh region
Authors:   ederal State Budgetary Educational Institution of Higher Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Health of the Russian Federation, Krivoruchko Irina Vladimirovna , Paraskevopulo Mikhail Georgievich ,   Bureau of the Federal State Institution «Main Bureau of Medical and Social Expert Examination in the Voronezh Region» of the Ministry of Labor and Social Development of Russia
Published: February 2022

The functioning of a natural focus of opisthorchiasis with a high level of epidemiological risk has been established within the borders of the Voronezh region, which forms the social and medical significance of the invasion. The aim of the study was study the epidemiology of opisthorchiasis and analyze the features of the clinical manifestations of the chronic opisthorchiasis invasion in the natural focus of the Voronezh region. Clinical and epidemiological data, the results of general clinical laboratory studies, as well as parasitological, serological, instrumental studies were analyzed. The epidemiological features of chronic opisthorchiasis have been studied and it has been established that the leading factor in the transmission of opisthorchiasis in the Voronezh region is the insufficiently thermally processed carp fish used for food. A detailed analysis of the clinical manifestations of helminthiasis was carried out and the main syndromes of chronic opisthorchiasis — asthenovegetative and dyspeptic — were identified. It was noted that there were no significant changes in hemogram parameters in the form of leukocytosis and eosinophilia. The biochemical parameters of the blood of patients with chronic opisthorchiasis also showed no deviations from normal values. During ultrasound of the abdominal organs, some patients showed hepatomegaly, diffuse liver changes, and biliary dyskinesia. The results of a serological blood test by ELISA revealed antibodies — immunoglobulins of class G — to the causative agent of opisthorchiasis in a small percentage of the infected, which is probably due to the significant immunosuppressive effect of the parasite. When carrying out parasitological diagnostics of helminthiasis — coproovoscopic examination by the method of acetic-ether deposition — the eggs of Opisthorchis felineus were found in 80.4 % of the infested. All patients underwent coproovoscopic examination once. It was found that the most valuable diagnostic method for verifying the diagnosis of chronic opisthorchiasis is coproovoscopy.
Creation of a model for studying the antiviral effect of small interfering RNAs in vitro
Authors:   I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia, Pashkov Evgeny Alekseevich , Korchevaya Ekaterina Romanovna ,   I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia, Faizuloev Evgeny Bahtierovich ,   I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia, Pashkov Evgeny Petrovich ,   Sechenov University, Moscow, Zaiceva Tatyana Aleksandrovna ,   Sechenov University, Moscow, Russia, Rtishchev Artem Andreevich ,   I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Poddubikov Alexander Vladimirovich ,   I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia, Svitich Oxana Anatol'evna ,   I. Mechnikov Research Institute of Vaccines and Sera, Sechenov University, Moscow, Russia, Zverev Vitaliy Vasil'evich ,   I. Mechnikov Research Institute of Vaccines and Sera, Sechenov University, Moscow, Russia
Published: February 2022

Influenza is a widespread respiratory infection, accompanied by damage to the lower respiratory tract of a person, and can lead to severe complications, up to a fatal outcome. Currently existing therapeutic agents and vaccines do not provide fully effective protection against influenza viruses. The development and creation of drugs based on the mechanism of RNA interference in the context of this problem is a promising direction. The aim of this study is to select and experimentally substantiate cellular target genes for miRNAs whose knockdown suppresses viral reproduction. A549 cells (human lung adenocarcinoma) were transfected with small interfering RNAs. After 4 hours, the transfected cells were infected with the influenza virus pri MOI = 0.1; 0.01 and 0.001. The virus-containing liquid was sampled within three days from the moment of transfection and the intensity of the dynamics of viral reproduction was assessed by the CPD titration method. The use of all small interfering RNAs at MOI = 0.1 resulted in a significantly significant decrease in the viral titer relative to non-specific control. Similar results were obtained at MOI = 0.01 and 0.001. The most effective siRNA ISSINUP98, since when using it, at MOI = 0.1, the viral titer values decreased by 1.7 lg TCD50/ml and by 3 lg TCD50/ml at MOI = 0.01 on the third day. The results showed that miRNAs directed to human cellular genes FLT4, Nup98 and Nup205, whose derivatives play an important role in the life cycle of the influenza virus, effectively reduce its reproduction in vitro. Thus, the studied genes and their products are potential targets for the development of anti-influenza drugs.
Hubungan indeks massa tubuh dengan rasio TG/HDL pada pasien diabetes mellitus tipe 2
Authors: Lumbantobing Andrico Napolin , Suandy Suandy , Lubis Ilham Akbar
Published: February 2022

Gambaran dislipidemia pada DM tipe 2 yang paling sering ditemukan adalah peningkatan kadar TG dan penurunan kadar HDL. Penelitian ini bertujuan menganalisis hubungan indeks massa tubuh dengan rasio TG/HDL pada pasien diabetes mellitus tipe 2. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross-sectional. Populasi pada penelitian ini adalah seluruh rekam medis pasien diabetes melitus yang tercatat dalam rekam medis RS Royal Prima dari April sampai Mei 2021. Metode pengambilan sampel dilakukan dengan metode total sampling. Jumlah sampel yang terlibat sebanyak 100 orang. Data diperoleh dari rekam medis pasien diabetes mellitus. Data dianalisis menggunakan uji Chi-Square. Hasil penelitian menunjukkan bahwa usia paling banyak terkena diabetes melitus tipe II yang paling tinggi pada mortalitas usia 40-60 tahun berjumlah 51 orang. Sementara distribusi proporsi pasien diabetes melitus tipe II berdasarkan jenis kelamin yang paling banyak adalah laki-laki yaitu 64 orang. Hasil uji bivariat menunjukkan bahwa usia tidak berhubungan dengan indeks massa tubuh (0,517). Demikian juga dengan hasil uji pada jenis kelamin, disimpulkan bahwa jenis kelamin juga tidak berhubungan dengan indeks massa tubuh (0,683). Sedangkan kadar rasio TG/HDL paling tinggi adalah 3,6-4,5 dengan jumlah total 44, sementara nilai rasio TG/HDL paling rendah adalah 1,1-2,5 dengan jumlah total 5.
PEMBINAAN NILAI-NILAI PENDIDIKAN MULTIKULTURAL DI SDN 54 ANAK AIR, PADANG
Authors:   STKIP YDB Lubuk Alung, Fitria Desi , Wahyuni Sri ,   STKIP YDB Lubuk Alung
Published: February 2022

This study describes how to foster multicultural education values at SDN 54 Anak Air. The type of research used is qualitative research with a descriptive approach. Research data were collected through observation, interviews and documentation studies. Data analysis was carried out by reducing data, presenting data and drawing conclusions. Test the validity of the data is done by triangulation of data sources. The research findings show that the interaction of students from different cultures in grades one, two and three tends to be awkward and closed. Meanwhile, the interaction at the further grade level is very intimate and tends to be open. The interaction of students with students from different cultures has shown an appreciation for cultural differences. So that in the interaction the values of multicultural education have been built, namely the value of tolerance and the value of equality. The interaction of teachers with students of different cultures shows the development of the values of multicultural education, namely the value of tolerance, democracy, the value of equality and the value of justice. Activities held at SDN 54 Anak Air both in-class and out-ofclass activities at SDN 54 Anak Air have included the values of multicultural education. The understanding of the teachers at SDN 54 Anak Air towards multicultural education is theoretically still lacking, however in their actions and treating students of different cultures it contains the values of multicultural education.
Paroxetine Repositioning – New Facets
Authors: Мангуби В.А. , Хаустова Е.А.
Published: February 2022

В статье рассмотрены некоторые исследования, посвященные репозиционированию лекарственных препаратов, в частности пароксетина в области онкологии, а также комбинированная терапия с противоопухолевыми препаратами и применение пароксетина как препарата выбора при тревоге и депрессии у онкологических пациентов.

The article discusses some studies on the repositioning of drugs, in particular paroxetine, in the field of oncology. The combination therapy with anticancer drugs and the use of paroxetine as the drug of choice for anxiety and depression in cancer patients.
At the dawn of the Late Bronze Age ‘globalization’, the (re)-circulation of Egyptian artefacts in Nubia and the Northern Levant in the MB II–mid MB III (c. 1710–1550 BC)
Authors: Miniaci Gianluca
Published: February 2022

The article analyses the circulation of late Middle Kingdom (mid MB I–MB I/II) Egyptian artefacts in the Northern Levant and Upper Nubia in the MB II–mid MB III (c. 1710–1550 BC). Three case studies have been selected: the royal tombs of Byblos, the tomb of the Goats at Ebla, and the Egyptian Cemetery at Kerma. Although the two regions were politically disconnected, their populations appropriated, reused, and occasionally reinterpreted Egyptian artefacts in a similar manner. These artifacts, although found in Second Intermediate Period contexts, generally dated to the mid MB I-MB I/II (late Middle Kingdom). It is suggested that the collapse of Egyptian central power at the end of the Middle Kingdom could have led to the recirculation of older Egyptian objects. The recirculation suggests that the ‘globalisation’, noted in archaeology and text during the Late Bronze Age (1500-1200 BC) in fact started in the first half of the Second millennium BC.
Producción de Cristina Di Bennardis/De Bernardi relativa a Historia del Cercano Oriente Antiguo
Authors: Di Bennardis/De Bernardi Cristina
Published: February 2022

Producción de Cristina Di Bennardis/De Bernardi relativa a Historia del Cercano Oriente Antiguo
The Effect of Single-Parent Parenting, Peer Conformity, and Self-Concept on Adolescent Religiosity
Authors: Setyaningsih Rina , Khodijah Nyayu , Munir Munir
Published: February 2022

The study aimed to prove the effect of single-parent (father) parenting and peer conformity on religiosity in adolescents in the Marga Sekampung sub-district, East Lampung district. The study was a quantitative study with a population and sample of 51 adolescents aged 10-16 years. Data was collected through questionnaires and documentation. Instrument validity was through Product Moment correlation and instrument reliability through the split-half technique. The data analysis technique is through the prerequisite test with normality and homogeneity tests, variable description, and the hypothesis test with simple linear regression and multiple regression tests. The study found that the effect of single-parent (father) parenting, peer conformity, and self-concept together on adolescent religiosity was 82.8% and 17.2% affected by other factors.
Covid-19 Pandemisi Sürecinde Tarihi Kent Dokusunda Mimari Stüdyo Deneyimi; Atatürk Üniversitesi Mimari Proje Stüdyosu VII
Authors: KAZAZ Emriye , DEMİRCAN Büşra
Published: February 2022

Mimarlık eğitiminin vazgeçilmez mekanları olan stüdyolarla ilgili olarak kullanılan yöntemler, sonuç ürünler ve deneyimler gibi farklı bakış açıları üzerine bugüne kadar birçok çalışma yapılmıştır. Bu çalışmaların ortak paydası stüdyo ortamlarının kendisinin eğitimin bir parçası olduğudur. Ne var ki, 2019 yılında başlayan Covid-19 pandemisi sürecinde birçok alanda olduğu gibi mimarlık eğitiminde de devrim niteliğinde ani bir değişim yaşanmıştır. Alışılagelen yüz yüze stüdyoların yerini çevrimiçi ya da uzaktan stüdyolar almıştır. Böylesine köklü bir stüdyo ortamı ve biçimi değişikliği hem stüdyo katılımcıları olan öğrenciler hem de yürütücüler açısından yepyeni bir deneyim olmuş ve birçok zorluğu da beraberinde getirmiştir. Mimarlık eğitimini kayda değer bir biçimde etkileyen bu sürecin paylaşılması ve farklı deneyimlerin aktarılması, sistemdeki aksaklıkların fark edilmesi ve geliştirilmesi açısından önemlidir. Bu bağlamda, “BigBlueButton” (BBB) uygulamasıyla çevrimiçi stüdyo olarak gerçekleştirilen Atatürk Üniversitesi Mimarlık Bölümü yedinci yarıyıl mimari proje stüdyosu kapsamında Erzurum tarihi kent dokusunda çalışılan öğrenci ve sosyal merkez, kent kütüphanesi, koruma ve sosyal merkez gibi sosyal ve kamusal içerikli projeler süreç kurgusu, bağlamsal analizler ve proje ürünleri üzerinden aktarılmıştır. Ayrıca stüdyo süreci boyunca pandemi koşulları ve çevrimiçi ortamlardan kaynaklı aksaklıklar ve geliştirilen olası çözüm yolları ifade edilerek sonuç kısmında uzaktan eğitim sürecinin olumlu ve olumsuz yanları üzerine değerlendirme yapılmıştır.
EFEKTIVITAS BANTUAN KEUANGAN DALAM MEWUJUDKAN KEMANDIRIAN PARTAI POLITIK DI PROVINSI JAMBI
Authors: Saadah Maratun
Published: February 2022

This study aims to see the effectiveness of financial assistance provided to political parties in order to realize party independence in Jambi Province. The presence of political parties is a consequence of the choice of the political system and form of government adopted by a country. Political parties have a central function as components in a democratic country like Indonesia. Political party financial assistance is deemed necessary to be given to political parties to carry out their functions, so that they are independent and free from personal interests. This research is a qualitative research conducted through in-depth interviews and described descriptively. The results showed that although the organizer of the aid in this case was the national and political unitary body of the Jambi Province, it had implemented regulations in accordance with the procedures, but the distribution of financial assistance was hampered due to the presence of parties that did not follow the procedures. Collective disbursement of aid is the cause of delays in the distribution of financial aid and leads to the ineffective use of financial aid funds by political parties as an effort to realize the independence of their parties.
ЎҚУВ АДАБИЁТЛАРИНИНГ ТУРЛАРИ ВА УЛАРДА МАТННИ ИНФОГРАФИКА КЎРИНИШИДА БЕРИШ ИМКОНИЯТЛАРИ
Authors: IBRAGIMOVA Hilola
Published: February 2022

Ахборот асрида маълумотлар сарҳадининг кенглиги аудиториянинг ахборот олишга бўлган талабини ҳам ўзгартирди. Бугун аудиториянинг алоҳида матн ёки одатий, овозли тасвир ва сўз уйғунлигидаги содда тузилишдаги материаллар билан чекланмай, ўзига хос қабул қилиниши осон, қулай, қийин ахборотни ҳам енгил, ҳам эсда қоларли ва кўркам тарзда олиш истаги юқори. Бу талаб таъсирида ўқув адабиётларига бўлган талаб ҳам ўзгарди. Дарсликларга енгил ва тез ўзлаштириш имконини берувчи форматларни киритиш тақозо этилади. Шу жиҳатдан, эндиликда ўқув адабиётларини тайёрлашга янгича ёндашиш зарур.
Мазкур тадқиқотда биринчидан, ўқув адабиётларининг таркибий тузилиши ва турлари, электрон дарсликлар ва уларнинг ўзига хос жиҳатларини намоён этишида инфографиканинг ўрни каби масалалар ўрганилган ва таҳлил этилган. Иккинчидан, инфографика ўқув адабиётларини бойитиши, уни таъсирчанлигини ошириши ва дарсликни ўзлаштирилиши жиҳатдан соддалаштириш имконини бериши ҳақида фикр-мулоҳазалар келтирилган. Тадқиқот натижалари шуни кўрсатдики, инфографикани нафақат ўқув адабиётларида, ўз навбатида, дарс жараёнларида ҳам бир неча усулларда қўллаш самарали. Ўрганишлар натижаси инфографика ўқув адабиётлари, умуман, дарс жараёнларини визуаллаштириш, соддалаштириш ва қизиқарли қилишда жуда самарали формат эканлигини тасдиқлади.
Design, Analysis and optimization of Hand Brake Lever
Authors: Deshpande Chaitanya P. , Badadhe Avinash , Khan Subim
Published: February 2022

In all automotive sector there is a linkage between brake mechanism and occupant known as a hand brake lever. Existing design is evaluated for optimization with use of composite material. CAD modeling of same will be done using CATIA V5 software. Finite element analysis approach is used to apply standard load on the part which is further investigated to perform Topology Optimization for material efficiency and reduction of cost. Existing design will then be machined as per topological optimization using Composite Material. Weight reduction of Brake lever will be done using Glass fiber epoxy composite
material for optimized model. Static analysis of glass fiber hand brake lever will be performed using ANSYS19 software. The comparison of results between existing material and proposed composite material is done by using the techniques of Modal analysis and Static condition analysis of the part
Analisi di un risultato inatteso: le elezioni regionali del 2005 in Puglia
Authors: Giaffreda Marco
Published: February 2022

Le elezioni regionali del 3-4 aprile 2005 in Puglia possono essere annoverate di diritto tra quelle di maggior interesse politologico sia per gli aspetti innovativi presenti, sia per il sorprendente esito. In una complessa tornata elettorale, per la prima volta in Puglia, un candidato alla carica di presidente della Regione è stato scelto attraverso elezioni primarie che hanno coinvolto la base dei partiti del centrosinistra, fornendo, come vedremo, una delle chiavi per il successo finale. Inoltre, dopo le elezioni del 2000, come del resto prevedeva il lungo processo di decentramento delle funzioni amministrative e di maggiore autonomia degli organi periferici dello Stato, si era aperta nella Regione una fase riformatrice che ha portato all’approvazione del nuovo Statuto regionale e di una nuova legge elettorale per l’elezione del presidente e del consiglio. Sul fronte strettamente elettorale i due principali candidati, Nichi Vendola per la Grande alleanza democratica (GAD), formata dall’Ulivo più Rifondazione comunista, e Raffaele Fitto, per la Casa delle Libertà (CDL), hanno dato vita ad una campagna fortemente personalizzata e speculare in cui sono emerse le profonde differenze tra i due e tra due modi (e concezioni) diversi di fare politica. La vittoria di Vendola, tutt’altro che scontata ma in qualche modo prevedibile, ha rappresentato, inoltre, un forte elemento di discontinuità rispetto al passato e alla tradizione politico-elettorale della Puglia. Per tutti questi motivi, quindi, sulle elezioni pugliesi si sono accesi i riflettori dei mass media nazionali.

Questo contributo ha l’obiettivo di descrivere e fornire una prima e parziale analisi del “terremoto pugliese”, dapprima attraverso una breve carrellata sulla storia del voto regionale in Puglia e sul contesto in cui si sono svolte le elezioni del 2005, per poi passare all’esame della nuova legge elettorale regionale, delle elezioni primarie nel centrosinistra e della loro influenza sull’esito finale della competizione, della campagna elettorale ed infine del risultato e delle possibili cause che l’hanno determinato.
Le elezioni politiche del 2001 e la questione dei seggi vacanti
Authors: Gigliotti Alessandro
Published: February 2022

Le elezioni politiche del maggio 2001 sono destinate a restare nella storia, quanto meno in virtù di un evento che non si era mai verificato in precedenza, vale a dire l’impossibilità di assegnare alcuni seggi della Camera dei deputati a causa dell’insufficienza di candidature delle liste di Forza Italia. Si è trattato di un problema complesso, originato dal tentativo di manipolare le disposizioni, che erano già di per sé alquanto complicate, della legge elettorale della Camera. In questo saggio si cercherà di ricostruire, in sintesi, i termini della questione ma, allo stesso tempo, di essere quanto più possibile esaustivi: dopo una breve introduzione volta a spiegare cosa sono le liste civetta, le principali imputate del pasticcio elettorale, si passerà a illustrare il tema dei seggi vacanti, in particolar modo alla luce dei lavori della giunta delle elezioni, esaminando le proposte avanzate per l’assegnazione dei seggi. Infine, si darà conto delle novità introdotte dalla legge n. 47 del 2005, approvata quando ormai si entrava nell’ultimo anno di legislatura e la questione dei seggi vacanti era definitivamente chiusa da diverso tempo.
La disciplina delle campagne elettorali nella prospettiva comparata: l'omaggio che il vizio rende alla virtù?
Authors: Fusaro Carlo
Published: February 2022

Il 9 gennaio 2003 il primo ministro israeliano Ariel Sharon stava tenendo una conferenza stampa, ripresa in diretta radiotelevisiva, per difendersi da accuse di corruzione. Ma dopo nemmeno dieci minuti, il suo intervento veniva interrotto. Un annuncio comunicava subito dopo che la trasmissione era stata sospesa per ordine del presidente del Comitato elettorale centrale, giudice Mishael Cheshin, perché le parole di Sharon costituivano “propaganda elettorale”. Era infatti in svolgimento la campagna per le elezioni parlamentari del 28 gennaio e, durante questo periodo, la propaganda è vietata dalla legge in tutti i programmi su radio e tv tranne che negli appositi spazi a disposizione dei partiti.

Un’esagerazione? Un’assurdità? Forse. Questa certo può essere l’impressione a prima vista. Ma è opportuno, invece, sfuggire alla tentazione di subire una sorta di crisi di rigetto.

Questo lavoro presenta, con qualche osservazione generale, il quadro giuridico-formale all’interno del quale si sviluppano (o si dovrebbero oggi sviluppare) le campagne elettorali, intendendo per “campagne elettorali” tutte quelle attività specificamente volte a conquistare voti alle elezioni con particolare riferimento al periodo più o meno lungo (formalmente o sostanzialmente) che precede il giorno delle elezioni. Escludo la campagna elettorale referendaria che ha comunque caratteri propri. Vorrei escludere anche (ma alcune legislazioni lo includono, per cui qualcosa dovrò necessariamente dire al riguardo) il periodo di tempo che va dalle elezioni fino alla campagna elettorale successiva. È quello che la legge americana chiama electoral cycle, a indicare che in realtà il lavoro indirizzato alla conquista dei suffragi non si interrompe che per qualche ora, subito dopo un’elezione: ma ricomincia subito dopo in vista delle elezioni successive quando che siano. Ovviamente vi sono comunque nessi stretti con la disciplina dei partiti politici e, in particolare, la disciplina del loro finanziamento, nonché la disciplina dei mezzi di comunicazione di massa, in particolare del settore radiotelevisivo. Tuttavia, nessuna di queste materie è oggetto specifico di questo scritto, anche se non potrò evitare riferimenti anche frequenti. Pure stretti sono i nessi con la disciplina del sistema elettorale e con la struttura e il formato della lotta politica. Va da sé che queste delimitazioni hanno, come si dice in questi casi, carattere meramente stipulativo e nessuna pretesa di intrinseca validità.
Study of one-step and two-step quench and partition heat treatments on a medium carbon high silicon alloy using dilatometry
Authors: Kurup V , Siyayisa CW , Mostert RJ , Moema J
Published: February 2022

This study evaluated the microstructural evolution in a medium carbon high silicon steel during one-step, and two-step quench and partition (Q&P) processes using dilatometry experiments. The two-step Q&P process was carried out using different quench temperatures ranging from 180 to 260 °C. In the one-step process, Q&P heat treatment samples were held isothermally for ten minutes after quenching at specified temperatures ranging between 200 and 4°50 C. The two-step Q&P process yielded a higher fraction of retained austenite than a one-step Q&P process. During the isothermal hold step, the volume expansion due to carbon partitioning and austenite decomposition behavior was interpreted by experimentally determined strain values. For the one-step Q&P process, the austenite decomposition kinetics above and below the Ms temperature differed, as evidenced by the JMAK parameters. The TTT diagram generated for the one-step Q & P process showed a “swing back” at a temperature of around 355 °C.
Using site occupation disorder to build bulk structures of Ni1-xAlx
Authors: Thesner CJ , Falch A , Cornelia G , Van Sittert CE
Published: February 2022

Raney nickel shows potential as an electrocatalyst for the oxygen evolution reaction (OER). However, the catalytic activity of Raney nickel varies with its properties. These properties are related to the composition of the bimetallic precursor used to synthesise Raney nickel. The bimetallic precursor consists of a combination of bimetallic phases. Various studies have been done on the well-known bimetallic phases, namely, Ni2Al3, NiAl and NiAl3. However, to get a more comprehensive understanding of the influence of the bimetallic precursor on the properties of Raney nickel, a larger spectrum of bimetallic phases needs to be evaluated. In this study, the Site Occupation Disorder (SOD) program was used to build solid-state structures (bimetallic phases) with various Ni1-xAlx bimetallic ratios. These Ni1-xAlx bimetallic phases were evaluated, and unique configurations for each Ni1-xAlx bimetallic ratio were obtained. The unique configurations were geometrically optimised using the General Utility Lattice Program (GULP) at 0K. These optimised unique configurations were thermodynamically evaluated over a range of 0.1K – 1200K, and the most stable configurations with a probability higher than 10% were identified. This study found that the stable non-homogeneous configurations fall within a range of 20% - 80% Ni content. A weight average combination of these configurations of the bimetallic phases will produce a non-homogeneous precursor with an average Ni content of 20% - 80%, which is in close agreement with experimental results. The approach in this study enables researchers to obtain a larger, repeatable spectrum of bimetallic phases for the investigation of Raney nickel precursors.