bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum fibroblast growth factor‑2 levels complement vital parameters for assessing prognostic status of heart failure
Authors: yu zelin , cai zehong , zheng jintao , jiang hongyan , zhou yanqiong , wong naikei , fu hongbo , hong xiaobing
Published: December 2023

Background: Prediction, early diagnosis, and treatment of heart failure are crucial. Fibroblast growth factor-2 (FGF2) may serve as a prognostic biomarker for heart failure owing to its ability to promote cardiac fibrosis and hypertrophy; however, the relationship between FGF2 concentration and heart failure is unclear. Therefore, this study aimed to explore whether FGF2 could aid in distinguishing patients with heart failure from healthy controls and those with dyspnea without heart failure and evaluate the possible correlation between serum FGF2 levels and its prognostic parameters in patients with heart failure.
Methods: Plasma FGF2 concentration was measured in 114 patients with complaint of dyspnea (enrolled in the study between January 2022 and August 2022). Based on heart failure diagnosis, the patients were assigned to three groups, as follows: heart failure (n = 80), non-heart-failure dyspnea (n = 34), and healthy controls (n = 36), following physical examination. Possible correlations between serum FGF2 levels and other prognostic parameters in patients with heart failure were analyzed.
Results: Serum FGF2 levels were higher in patients with heart failure (125.60 [88.95, 183.40] pg/mL) than in those with non-heart-failure dyspnea (65.30 [28.85, 78.95] pg/mL) and healthy controls (78.90 [60.80, 87.20] pg/mL) (p <0.001). Receiver operating characteristic curve analysis identified FGF2 concentration as a significant predictor in heart failure diagnosis, with an area under the curve of 0.8693 (p <0.0001). Importantly, in the heart failure group, serum FGF2 concentrations correlated with key prognostic parameters for heart failure, such as reduced left ventricular ejection fraction and elevated serum levels of N-terminal pro-B-type natriuretic peptide.
Conclusion: Elevated serum FGF2 level is strongly associated with an increased risk of heart failure and could serve as a useful biomarker to complement vital prognostic parameters for heart failure.
Incidence and Predictors of mortality among chronic kidney disease patients on dialysis in Sidama region, Ethiopia: A Retrospective cohort study.
Authors: Alemayehu Akalewold , Ashole Agune , Belyaneh Fanuel , Melak Kumilachew , Wondirad Mekdes , Taffese Temsegen
Published: December 2023

Introduction:
Chronic kidney disease is major cause of global morbidity and mortality. The upsurge of the number of patients with end stage renal disease needs attention across the globe and hence these patients are in need of renal replacement therapy. But there is paucity of information on predictors of mortality among patients on dialysis. Hence, it is important to identify those predictors of mortality in order to attempt the appropriate management.
Objective
To determine incidence of mortality and identify predictors of mortality among chronic kidney disease patients on dialysis at Yanet internal medicine specialized center, Hawassa, Ethiopia from September 2015 to February 2022.
Methods and materials
: Retrospective cohort study was conducted among chronic kidney disease patients on dialysis in Hawassa Yanet internal medicine specialized center. Data abstraction form was used to collect data from 260 patients from September 2015 to February 2022.The collected data was entered to EPI data and analyzed using STATA. Frequencies with percent, mean with standard deviation and median with interquartile range were used to describe and summarize the variables. Kaplan-Meier and log rank test were used to compare survival probability. Cox proportional hazard regression model was used to identify predictors of mortality on dialysis.
Result
Of the total 251 participants 176(70.1%) were male. The average age at the start of hemodialysis was 51.76 ± 13.22 (mean ± standard deviation). The incidence of mortality was 2.77 (95%CI (2.25–3.41)) per 100 person-month at risk. Age between 40–59 and ≥ 60 [AHR: 3.76; 95%CI (1.13–12.54); AHR: 5.66; 95% CI (1.72–18.66)], presence of diabetic mellitus (AHR: 1.7; 95% CI (1.08–2.70)), use of venous catheter as vascular access (AHR: 0.55; 95% CI (0.31–0.98)) were the main predictors of mortality.
Conclusion
This study revealed incidence of mortality and identified age, diabetic mellitus and vascular access type as significant predictors of mortality. Therefore, there should be close follow up for patients with comorbidities and choice of vascular access should be considered before hemodialysis initiation.
Co-targeting CD47 and VEGF Elicited Potent Antitumor Effects in Gastric Cancer
Authors: Zhang Kaiqi , Xu Yuan , Chang Xusheng , Xu Caili , Xue Wenjing , Ding Dan , Nie Mingming , Cai Hui , Xu Jun , Zhan Lu , Han Jiangbo , Cai Tiancai , Ju Dianwen , Feng Li , Zhang Xuyao , Yin Kai
Published: December 2023

Background
CD47, serving as an intrinsic immune checkpoint, has demonstrated efficacy as an antitumor target in hematologic malignancies. Nevertheless, the clinical relevance of CD47 in gastric cancer and its potential as a therapeutic target remains unclear.
Methods
The expression of CD47 in clinical gastric cancer tissues was assessed using immunohistochemistry and western blot. Patient-derived cells were obtained from gastric cancer tissues and co-cultured with macrophages derived from human peripheral blood mononuclear cells. Flow cytometry analyses were employed to evaluate the rate of phagocytosis. Humanized patient-derived xenografts (Hu-PDXs) models were established to assess the efficacy of anti-CD47 immunotherapy or the combination of anti-CD47 and anti-VEGF therapy in treating gastric cancer. The infiltrated immune cells in the xenograft were analyzed by immunohistochemistry.
Results
In this study, we have substantiated the high expression of CD47 in gastric cancer tissues, establishing a strong association with unfavorable prognosis. Through the utilization of SIRPα-Fc to target CD47, we have effectively enhanced macrophage phagocytosis of PDCs in vitro and impeded the growth of Hu-PDXs. It is noteworthy that anti-CD47 immunotherapy has been observed to sustain tumor angiogenic vasculature, with a positive correlation between the expression of VEGF and CD47 in gastric cancer. Furthermore, the successful implementation of anti-angiogenic treatment has further augmented the antitumor efficacy of anti-CD47 therapy. In addition, the potent suppression of tumor growth, prevention of cancer recurrence after surgery, and significant prolongation of overall survival in Hu-PDX models can be achieved through the simultaneous targeting of CD47 and VEGF using the bispecific fusion protein SIRPα-VEGFR1 or by combining the two single-targeted agents.
Conclusions
Our preclinical studies collectively offer substantiation that CD47 holds promise as a prospective target for gastric cancer, while also highlighting the potential of anti-angiogenic therapy to enhance tumor responsiveness to anti-CD47 immunotherapy.
Development and Validation of a Novel Prognostic Model for Lower-Grade Glioma Based on the m6A-regulated Genes
Authors: Zhang Yiling , Luo Na , Li Xiaoyu , Zhu Wenjun , Fu Min , Yang Feng , Chen Ziqi , Zhang Qiang , Peng Bi , Chen Xin , Li Qianxia , Liu Yuanhui , Zhang Yuanyuan , Peng Xiaohong , Hu Guangyuan
Published: December 2023

Background: Methylation of N6-methylandenosine (m6A) has important roles in the growth of tumors and cellular biological processes. The immune system is involved in tumourigenesis and development, and plays a certain role in tumour therapy and in resistance to drugs. There have been no in-depth studies on m6A-related immune markers in Low Grade Glioma (LGG).
Methods: LGG patients' mutation data and gene expression and related clinical information were obtained from the China Glioma Genome Atlas (CGGA) database and The Cancer Genome Atlas (TCGA). The prognostic model was calculated using multivariate Cox, LASSO, univariate Cox and other analytical approaches. All data was classified by two-cluster typing. Finally, we determined the biological role of FBXO4 in glioma cells by quantitative reverse transcription-polymerase chain reaction, cell proliferation assay and cell migration assay.
Results: The prognostic model for LGG worked well. It has an area under the curve over 0.9. The survival curve for the cluster typing and the Sankey diagram showed that high m6A levels corresponded to high expression of m6A regulatory genes and immune genes, and were associated with a higher degree of immune infiltration and lower survival rates. Finally, silencing FBXO4in glioma cell lines can significantly inhibit their proliferation and migration ability.
Conclusion: Prognostic models can accurately and efficiently help investigators analysis the prognosis of LGG patients. And the correlation analysis between m6Ascore and tumor microenvironment can provide a basis for further exploratio. Finally, FBXO4 is an important biomarker for the diagnosis and prognosis of Low Grade Glioma.
Effects of Maxwell velocity slip and Smoluchowski temperature conditions on thermal radiative MHD Fe_3O_4-Al_2O_3-Cu/H_2O tri-hybrid nanofluid flow past an exponential shrinking surface with entropy production: A stability analysis performance
Authors: mandal Gopinath
Published: December 2023

This investigation aims to determine the existence of a dual solution in magnetohydrodynamic (MHD) thermal radiative tri-hybrid nanofluid flow over an exponential shrinking surface by considering mass suction effects at the surface. Furthermore, the impacts of Smoluchowski temperature and Maxwell velocity effects are taken into account. The products on various flow fields are examined for three different types of fluid: mono nanofluid ($Fe_3O_4$/$H_2O$), hybrid nanofluid ( $Fe_3O_4$-$Al_2O_3$/$H_2O$), and tri-hybrid nanofluid ($Fe_3O_4$-$Al_2O_3$-$Cu$/$H_2O$). Estimating entropy production is also included in the current work. The similarity transformation is used to translate the nonlinear partial differential equations (PDEs) into a set of ordinary differential equations (ODEs). The numerical MATLAB function bvp4c is utilized in the construction and solution of governing higher-order nonlinear ODEs. The stability of these numerical solutions is achieved by finding the lowest eigenvalue because of the duality present in the solutions. A minimum eigenvalue that is positive denotes the upper stable solution branch, whereas a minimal eigenvalue that is negative indicates the bottom unstable solution branch. A tabular and graphic analysis is conducted on the impact of emergent factors on temperature, skin friction coefficient, Nusselt number, entropy generation, etc. The results also demonstrate that when mono nanofluid changes to hybrid nanofluid and hybrid nanofluid to tri-hybrid nanofluid, the velocity and profile improve. It has been demonstrated that the fluid's temperature and the pace at which heat is transferred are greatly influenced by the thermal radiation parameter. The magnetic field aggravates flow in the case of a stable solution. The production of entropy is also accelerated considerably by thermal radiation. The current optimization technique offers a new and beneficial insight into the production of plastic films, heat exchangers, polymer sheets, crude oil, and electronic devices. Therefore, it is advised to use the results to create an industrial device setup.
Study on the Impact of Urban Expansion on Ecosystem Service Value and Trade-off Synergy in Zhengzhou-Kaifeng-Port 1
Authors: Jia Qi , Liu Yijie , Zhang Chaoyu , Yin Zekai
Published: December 2023

It is of great significance to analyze and predict the evolution characteristics and trade-off synergies of ecosystem services in rapidly urbanized areas for improving the function of regional ecological restoration. Based on the future land use simulation and the method of equivalent scale estimation, this paper analyzed and predicted the characteristics of ecosystem service value (ESV) from 1990 to 2030, and combined with the correlation index, analyzed the trade-off synergy relationship between ecosystem services in 2030. The results showed that: (1) From 1990 to 2030, ESV in the study area fluctuated and decreased slightly. From 1990 to 2000, ESV decreased significantly, and gradually increased after 2000. As far as ESV is concerned, its regulation service function is the strongest, especially hydrological regulation, accounting for 54.51%. Agricultural production and the transfer in and out of waterspace ecological land are the key factors for the improvement and deterioration of ESV. (2) The spatial pattern of ESV in Zhengzhou-Kaifeng-Port area is higher in the north and lower in the west and the middle and east. Under the scenario of urban development, the decline was the most obvious, while under the scenario of cultivated land protection, ESV tended to be stable in most areas, and the bare land in the middle of the Yellow River continued to turn to agricultural production land, which promoted the increase of ESV. During the study period, the center of gravity of ESV was always located at the junction of Dameng Town and Guandu Town in Zhongmou County, and continued to shift to the northeast. (3) The synergistic relationship of ecosystem services is obvious, and the trade-off relationship is less and mainly exists between regulation and support services. This study is of great significance to accurately grasp the trade-off and synergy relationship of ecosystem service value under rapid urban expansion, and can provide a scientific basis for ecological restoration in rapid urbanization areas represented by Zhengzhou-Kaifeng-Port.
A retrospective analysis of predictors and outcome in patient pronounced thrombocytopenia after sutureless and standard stented aortic valve replacement
Authors: Zientara Alicja , Salmasi Mohammad Yousuf , Chaatrisha Bella Milan , Kapadia Sharan , Bashir Ryan , Cummings Ian , Quarto Cesare , Asimakopoulos George
Published: December 2023

Objectives
Thrombocytopenia following Perceval aortic valve replacement has been described previously with variable outcome. Studies have lacked a robust analysis of platelet fluctuation and factors affecting it. We aimed to statistically describe the trend in thrombocyte variability as compared with conventional aortic valve replacement, and to assess predictors as well as impact on associated outcomes.
Methods
100 consecutive patients with first-time Perceval were retrospectively compared to 219 patients after Perimount Magna Ease valve replacement. The primary outcome was the serial thrombocyte count on day 0–6. Generalized estimating equations were used to analyse the data using fixed-effect models: for the effect of the post-operative day on platelet count, and random-effect models estimating both time-variant (platelets) and time in-variant variables (valve type, age, LV function, pre-op platelet level).
Results
Perceval patients were older (72 ± 1 vs 68 ± 1 years,p < 0.01) with higher NYHA status (3(2–3) vs 2(1–2),p < 0.001). Mean thrombocyte count in the sutureless group was lowest on day 2 (91.9 ± 31.6 vs 121.7 ± 53.8 x103µl− 1), and lower on day 4 (97.9 ± 44) and 6 (110.6 ± 61) compared to the conventional group (157.2 ± 60 and 181.7 ± 79) but did not result in a higher number of transfusions, bleeding or longer hospital stay (p > 0.05). Reduced platelet count was a strong predictor of red cell transfusion in the conventional(p = 0.016), but not in the sutureless group(p = 0.457). Age (Coef − 1.025, 95%CI-1.649 - -0.401,p < 0.001) and CPB-time (Coef 0.186, 95%CI-0.371 - -0.001,p = 0.048) were predictors for lower platelet levels.
Conclusion
Considering the older patient profile treated with Perceval, postoperative thrombocytopenia does not impact on outcome in terms of transfusions, complications or hospital stay.
Concordance of movements and songs enhances receiver responses to multimodal display in the starling
Authors: Rusiecki Stanisław , Ręk Paweł
Published: December 2023

Many animals produce signals that consist of vocalizations and movements to attract mates or deter rivals. We usually consider them as components of a single multimodal signal because they are temporally coordinated. Sometimes, however, this relationship takes on a more complex spatiotemporal character, resembling choreographed music. Timing is important for audio-visual integration, but choreographic concordance requires even more skill and competence from the signaller. Concordance should therefore have a strong impact on receivers; however, little is known about its role in audio-visual perception during natural interactions. We studied the effects of movement and song type concordance in audio-visual displays of the starling, Sturnus vulgaris. Starlings produce two types of movements that naturally appear in specific phrases of songs with a similar temporal structure and amplitude. In an experiment with a taxidermic robotic model, males responded more to concordant audio-visual displays, which are also naturally preferred, than to discordant displays. In contrast, the effect of concordance was independent of the specific combination of movement and song types in a display. Our results indicate that the concordance of movements and songs was critical to the efficacy of the display and suggest that the information that birds gained from concordance could not be obtained by adding information from movements and songs.
Minimum Inhibitory Concentration and Minimum Bactericidal Concentration of Annona muricata ethanolic leaf extract on Porphyromonas gingivalis (ATCC 33277) and Streptococcus sanguinis (ATCC 10556) (In-vitro)
Authors: Alima Indira Rezka Nur , Auerkari Elza Ibrahim , Gultom Ferry Pergamus , Suhartono Antonius Winoto , Pasaribu Roben Suhadi , Auerkari Pertti
Published: December 2023

Background
Periodontitis is an oral disorder triggered by chronic inflammation, and a major cause of human tooth loss. Porphyromonas gingivalis is a prominent component in the etiology of chronic periodontitis which forms a bacterial “red complex” with Tannerella forsythia and Treponema denticola. P. gingivalis can invade the periodontal tissue and lower the host-defense mechanisms by deregulating immune and inflammatory responses. In parallel, Streptococcus sanguinis represents oral commensal bacteria that act as pioneers for bacterial colonization in biofilm formation. A plant of traditional medicine to inhibit bacterial growth is soursop (Annona muricata L.) that contains active chemical compounds, namely alkaloids, phenolics, flavonoids, and tannins.
Aim
The study aimed to determine the antibacterial effectiveness of soursop leaf extract on P. gingivalis and S. sanguinis, and to compare the effect of the extract to that of the positive control of 0.2% chlorhexidine.
Methods
Ethanol extract of soursop leaves was prepared at concentrations of 60, 50, 25, 12,5, 6,25, and 3,125 vol%. The antibacterial effectiveness of soursop leaf extract on P. gingivalis dan S. sanguinis is tested for Minimum Inhibitory Concentration and Minimum Bactericidal Concentration.
Results
The observed MIC values of soursop leaf extract on P. gingivalis and S. sanguinis were 25% and 12,5%, while the MBC values were 50% and 60% (vol), respectively. There were significant differences in the inhibitory concentration of soursop leaf extract and positive control by 0,2% chlorhexidine against both P. gingivalis and S. sanguinis in post-hoc Tukey test (p ≤ 0.05).
Conclusion
Ethanol extract of soursop leaves can effectively inhibit and kill P. gingivalis and S. sanguinis in vitro.
Antibacterial Potential of Ethanol Extract of Plectranthus amboinicus (Lour.) Spreng against Streptococcus mutans serotype C and Streptococcus sanguinis
Authors: Kamilla Devasya Nathania , Auerkari Elza Ibrahim , Gultom Ferry Pergamus , Pasaribu Roben Suhadi , Auerkari Pertti
Published: December 2023

Caries is the most prevalent disease in the world, and in Indonesia its prevalence is 88.8%. While the causative microbial agent of caries is Streptococcus mutans, Streptococcus sanguinis is a primary colonizer related to the formation of oral biofilms. Due to concerns on cost, access and side effects of the commercial solutions, many people still depend on plant-based medicinal alternatives. Plectranthus amboinicus (Lour.) Spreng is such a medicinal plant containing carvacrol and thymol that are known to have antibacterial effects.
Aim: To determine the effectiveness of P. amboinicus extract in inhibiting growth of and killing S. mutans and S. sanguinis.
Methods: Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined to characterize the antibacterial properties of the ethanol extract of P. amboinicus from extract concentrations of 50%, 25%, 12.5%, 6.25 %, and 3.125% (vol) against the two bacterial species.
Results: MIC and MBC levels of the ethanol extract of P. amboinicus against S. mutans were 3.125% and 50%, respectively. The corresponding MIC and MBC levels of the extract against S. sanguinis were respectively 6.25% and 25%l test showed a significant difference between each treatment (p <0.05).
Conclusion: Ethanol extract of P. amboinicus can effectively inhibit growth of and kill S. mutans and S. sanguinis.
Hesperetin-loaded chitosan nanoparticles ameliorate hyperglycemia by regulating key enzymes of carbohydrate metabolism in STZ-induced high-fat diet fed diabetic Wistar rats
Authors: Natarajan Ashokkumar , Radhakrishnan Sivamathi Rathna Priya , Mohan Karthik
Published: December 2023

Type II diabetes mellitus (T2DM) is the most common severe metabolic disease and is considered one of the top five causes of death worldwide. Screening blood glucose levels measured in obese individuals is more effective in identifying undiagnosed individuals than screening tests in the general population and therefore introduces selection bias in detection from a molecular and morphological standpoint, so this paradigm can be used to investigate the antidiabetic efficacy of medicinal plants or herbs. Hesperetin, due to its therapeutic efficacy. Hesperetin has been demonstrated to have positive benefits, however, it falls short of being completely effective because of its weak water solubility and bioavailability. Our study aims to create chitosan nanoparticles with hesperetin to improve antidiabetic effects in rats with obesity-related diabetes caused by a high-fat diet. Accordingly, the experimental animals were made diabetic by feeding them a high-fat diet for 28 days followed by injection of a low dose of streptozotocin (STZ) (35 mg/kg b.w; 0.1 M citrate buffer; pH 4.0) were made diabetic and a significant (P < 0.05) decrease in blood glucose and glycosylated hemoglobin was observed along with an increase in plasma insulin levels. The existence of dimension, shape, and size has been confirmed by characterization investigations such as SEM, zeta potential, particle size analyzer, and FT-IR examination. Blood glucose, insulin levels, total glycogen, and carbohydrate metabolism are biochemical variables. Overall, the 20 mg/kg b.w the effective findings of hesperetin-loaded chitosan nanoparticles (HSPCNPs) demonstrate potent anti-inflammatory, antidiabetic, and antiobesity agents.
Modify the Polyvinylidene Fluoride: Polyacrylonitrile Blend Nanofiber to Improve Membrane Filtration Efficiency.
Authors: Habeeb Salih Abbas
Published: December 2023

With the increasing sources of water pollution, there has been great interest in improving the efficiency of filtration membranes, which comes from obtaining a porous and high membrane surface area by electrospinning. In this research, we worked on producing a membrane from polyvinylidene fluoride (PVDF) and polyacrylonitrile (PAN), then strengthening it with titanium isopropoxide (Tipp) and converting PAN to amidoxime polyacrylonitrile (AOPAN) by reaction. Many physical tests were conducted, such as wettability, field emission scanning electron microscopy (FE-SEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) to determine the efficiency of the membranes. The developed membrane has high crystalline and thermal properties, and the surface is characterized by high wettability compared to the properties of the undeveloped membrane. On the other hand, the developed membrane has a low pore size and high porosity, which increases the water flux rate to 804 (Lm-2.h-1) and reduces the milk protein flux rate to 145 (Lm-2.h-1), besides increasing the flux recovery ratio, solute rejection, and rejection rate to 91.79%, 89.61%, and 81.97% respectively.
Advancing Personalized Recommendation Algorithms with RNN and Multimodal Features
Authors: Neri Chiara , Ferri Viola , Lombardi Renato
Published: December 2023

Traditional recommendation systems, employing collaborative filtering (CF) methods, recommend related videos for a given seed by considering how many users watched a particular candidate video immediately after the seed video. This approach primarily relies on aggregate user behavior and does not take into account the content of the videos. Current recommendation systems can recommend content across different media types, including text, images, audio, and video. This is achieved by pre-tagging various media files with different labels and then using search engines to find content based on user needs. However, with the evolution of video platforms, user demands for personalization have become stronger, and recommendation scenarios have become more complex. There is an increasing need for precision in video recommendations. To address the limitations, we focus on integrating multiple modalities into recommendation systems. The main contributions of this work are: We explore how to effectively integrate the various modalities to reflect user preferences and how they affect recommendation performance. We perform extensive experiments on public dataset to demonstrate the performance of our proposed model.
Influence of the orientation of constructed blood vessels during the 3D printing on the measurement of the pseudo-oxygen saturation of an artificial blood substitute using conventional oxygen sensors: a test series
Authors: Jung Svenja , Hoffmann Martin , Winkler Dirk , Güresir Erdem , Kropla Fabian , Scholz Sebastian , Grunert Ronny
Published: December 2023

Background: The development of phantoms to reduce animal testing or to validate new instruments or operation techniques is of increasing importance. On this account, a blood circulation-phantom was developed and used to evaluate conventional oxygen sensors for a newly developed spatula for direct measurement of the blood oxygen saturation at the parenchyma.
Methods: A solution of copper and nickel sulfate was used as blood substitute. A total of seven different solutions with a pseudo-saturation between 50 % and 100 % were created. To evaluate the solution as a suitable blood substitute, a two-stage feasibility study was conducted. This study consisted of capturing the absorption spectra of the two sulfate solutions and calibrating the used oxygen sensor. Additionally, blood vessels with a simplified geometry were designed and manufactured using an elastic material (Elastic 50A) with a 3D printer (Formlabs Form 2). To determine the orientation during the printing process, various vessels were printed. Measurements to assess the effects of disturbance (rotation of the vessels during measurements) on the sensor readouts were prepared.
Results: Upon analyzing the absorption spectra of the blood substitute and ordinary blood, it was observed that the components of the solution behaved similarly to oxygenated and deoxygenated blood, confirming the suitability of copper and nickel sulfate as a blood substitute. The impact of disturbances was also verified through the rotation of the 3D-printed vessels. It was shown that a measurement directly on the disturbances led to outliers and higher values. An optimal orientation was determined to be a lateral placement (90° or 270°) of the sensor. Regarding the orientation of the vessels within the printing space, an orientation of 45° yielded the best results, as the individual layers least affected the light emitted and received by the oxygen sensor. All results pertain to constructed vessels developed using a Formlabs Form 2 printer and Elastic 50A material by Formlabs.
Conclusion: The achieved results demonstrate the influence of the orientation of the vessel during 3D printing as well as the influence of the position of the vessel during the measurement using a conventional oxygen sensor.
Oral supplementation of njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parameters
Authors: Florent SOH NDE , Horliane GHOMDIM NZALI , Richard EJOH ABA
Published: December 2023

Background
Obesity has become one of the most common metabolic disorders in the world, characterized by the accumulation of excess fat in the body. Research for natural compounds to improve obesity has become increasingly important. This study aims to explore the effects of Sardina pilchardus and Ricinodendron heudelotii oils on the management of obesity. Njansan (R. heudelotii) oil was extracted by cold pressing using an automatic oil press machine and sardine fish oil by a cooking method. To evaluate the anti-obesity effect of these oils, 6 groups of 6 male Wistar rats were fed different diets: C0 group received a normal diet; HFD was fed a high-fat diet; N1, N2, F1and F2 followed by a high-fat diet supplemented with njansan and sardine oils at 1g/kg body weight/day and 2g/kg body weight/day, respectively.
Results
It appears that regardless of the type of oil, the acid and peroxide values meet the standards prescribed by the Codex Alimentarius. There was an increase in body weight, relative abdominal fat, and liver weight in the HFD group compared to the control group. There was also a decrease in anthropometric parameters such as the Lee index of the HFD group treated with njansan and fish oils, regardless of the concentration. The hyperlipidemic state in the HFD-fed rats was then normalized after treatment with both oils as well as hyperglycemia compared to the control group. Besides, fish and njansan oils attenuated HFD-induced oxidative stress, as indicated by a significant increase CA and SOD.
Conclusion
This study demonstrated that njansan and sardine oils at a low daily dose (1g/kg body weight) can be helpful in managing obesity and also reduce the risk of developing coronary heart diseases.
Kualitas Fisik Lingkungan Kawasan Permukiman di Sempadan Rel Kecamatan Labuhan Ratu, Bandar Lampung
Authors: Wahyuningsih Panti , Sulistyorini Rahayu , Sutiyoso Bambang Utoyo
Published: December 2023

Title: Physical Environmental Quality of Residential Areas on the Railway Boundary Labuhan Ratu Sub-district, Bandar Lampung
 
The high demand for land and limited availability have caused built-up land to move to suburban areas of the city. The concentration of activities, such as establishing settlements and higher education centers, has also influenced the development of built-up land around them. Low-income people take advantage of the opportunities available by utilizing vacant land as a place to live. Land use that is carried out continuously and uncontrollably has an impact on the railway boundary. This study aims to identify the physical condition of the environment in residential areas in Labuhan Ratu Subdistrict, especially in the railroad border area. The method used is descriptive qualitative. The results found that the existence of settlements on the railroad border in Labuhan Ratu Subdistrict is included in the category of illegal settlements. Infrastructure conditions such as drainage, lighting, waste management, clean water, and others could be better; the topographic conditions of the area also support this. Increasingly dense illegal settlements and poor infrastructure conditions will affect environmental conditions, such as decreased land balance and environmental quality.
Spatio Temporal Assessment of Vegetational Health in Ede South Local Government Osun State, Nigeria
Authors: Oladejo Sunday Olukayode , Arokoola Kayode Mathew , Amodu Taiwo
Published: December 2023

Plant health is a major concern of any Agricultural concern as they determine directly or indirectly the level of Agricultural production and by extension, the food security of any country. The assessment was carried out using integrated remote sensing and GIS techniques in Ede South local government of Osun State, Nigeria. Temperature, Relative humidity, Soil Type and Moisture content were the environmental factors considered. Vegetational Indices (NDVI, SAVI, NDWI, SIPI) were assessed in tandem with LST and environmental factors such as Temperature and Precipitation on a multi temporal basis. NDVI values decreased within a range of (-0.56 to -0.02) from 2017 to 2019, with a subsequent increase from 2019 to 2021 by (0.02 to 0.47). Moisture content measured through NDWI decreased within a range of (-1 to -0.08) from 2017-2019, then increased from 2019 to 2021 by (0.01 to 0.46)The vegetation of the area was very unhealthy around April, 2019 as a result of very low levels of moisture content, hence moisture content is an important environmental factor of plant health as a decrease in the moisture content of the vegetation in the study area led to a corresponding decrease in the vegetation health of the study area. Variance in moisture content was found to be the principal factor in the variation of the vegetational health condition over space and time. Spatio-temporal assessment of vegetational indices should be encouraged for assessing the contributory factors influencing vegetational health conditions as integrated GIS techniques have proven beyond doubt the capabilities of spatial analysis.
Aportes para la historia de la Dipterología Neotropical: In memoriam Dr. Sixto Coscarón (1926-2022)
Authors: Ibáñez Bernal Sergio
Published: December 2023

Se presenta una relatoría de las actividades académicas del Dr. Sixto Coscarón (1926-2022), como homenaje a este destacado entomólogo argentino. Se incluye su labor científica, se presentan listas de sus publicaciones y los nuevos taxones descritos por él para la ciencia.
Effects of Ficus Platyphylla-Induced Hypothermia on Long-term Functional Recovery after Ischaemic Stroke
Authors: Becker Axel , Helmuth Martin , Chindo Ben A,
Published: December 2023

A stroke is a cerebrovascular disease that results from a blockage in the blood supply to part of the brain or a burst blood vessel in the brain. It is the second leading cause of death worldwide, with an annual mortality rate of about 5.5 million. Antithrombotic therapies have failed to provide a cure for this debilitating cerebrovascular disorder, and hypothermia is gaining interest as a novel strategy for the management of stroke. In this study, we evaluated the effects of Ficus platyphylla-induced hypothermia on long-term functional recovery after ischaemic stroke. Histomorphological analysis of the brain demonstrated pathological alterations in the ipsilateral hemisphere of all animals. Animals treated before or immediately after permanent occlusion of the middle cerebral artery (MCAO) had significantly smaller infarct sizes than those given saline. Surgery and treatment did not affect locomotor activity. There were no significant differences between the groups of mice in terms of parameters associated with situational anxiety, including the number of arm changes and percentile time spent on open arms. There were no significant differences between groups regarding the number of buried marbles and sociability. Surgery and treatment did not affect social recognition, but a significant interaction between surgery and treatment was observed. The time mice remained on the rota rod was relatively similar for all groups tested, with no significant differences related to surgery and treatment, nor was there any surgery/treatment interaction. A learning effect represented by a decrease in exploratory activity was observed irrespective of surgery and treatment, and there was no surgery/treatment interaction. The results suggest that Ficus platyphylla-induced hypothermia could be beneficial to long-term functional recovery after ischaemic stroke.
Animating Absence: Exploring Ekphrasis and Prosopopoeia in Thomas Hardy’s “The Voice”
Authors: Fatah Shajwan Nariman
Published: December 2023

Thomas Hardy's "The Voice" (1914) is written in quatrains and employs a monologue structure. Conventionally, it is interpreted as a reflection of the poet’s personal experiences, notably his sense of an absent voice and the apparition of his wife, Emma. This study deviates from biographical interpretations, instead, it sheds light on a detailed analysis of the verse’s rhetorical elements. Through semiotic reading, I will investigate the process of animating the image of the absent female figure in the work by exploring ekphrasis and prosopopoeia. Therefore, the primary goal of this paper is to examine the poem's inherent aesthetic qualities by decoding the signs and symbols within expressions in the language. This essay shows the essence of the literary devices as the speaker depicts the face of the missing woman, and also, it reveals the paradox related to the timespan which operates dynamically, shifting back and forth between the characters.
Guía de campo ilustrada. Suelos en zonas aptas para aguacate Hass en el departamento del Cauca
Authors: Correa Moreno Diana Lucía , Garavito Morales Lina Vanessa , Polo Carrera Sebastián
Published: December 2023

En cultivos de aguacate Hass, la capacidad productiva depende de la interacción de múltiples factores, dentro de los cuales se encuentran las condiciones edáficas del territorio. Con el objetivo de disminuir las brechas tecnológicas identificadas para el cultivo en el departamento del Cauca, la cartilla presenta información de referencia sobre la morfología y las propiedades de diferentes perfiles de suelo. Esta guía de campo aporta información de referencia validada que puede ser consultada por asistentes técnicos y productores interesados en identificar suelos con características adecuadas para la producción de aguacate Hass en el área de influencia de municipios productores en el departamento del Cauca, en particular de Cajibío, Caldono, Caloto, Corinto, El Tambo, Morales, Popayán, Piendamó, Sotará, Timbío y Toribío.
Air Quality Monitoring with Speech Announcements
Authors: Chougule Prof. Sadhana
Published: December 2023

Abstract: In this project, we design and develop an advanced weather station system using an ESP32 microcontroller, temperature sensor, humidity sensor, and air quality sensor. The primary objectives of this project are data collection, visualization, and auditory feedback. The ESP32 microcontroller acts as the central processing unit and connects to the internet via Wi-Fi to transmit real-time sensor data to an IoT platform. This platform stores and manages the data, making it accessible from anywhere with an internet connection. Users can monitor temperature, humidity, and air quality remotely through a userfriendly web interface Additionally, the project incorporates a display screen that provides local, real-time weather information for on-site users. This display enhances the accessibility of weather data, even in the absence of internet connectivity. To ensure inclusivity and accessibility, the system employs a speech-to-text algorithm implemented in Python. At predefined intervals, the system announces the sensor data via a speaker using text-to-speech (TTS) technology. This feature aids visually impaired individuals in accessing weather information in an auditory format. The combination of sensor integration, IoT connectivity, data visualization, and text-to-speech capabilities creates a comprehensive and user-friendly weather monitoring system suitable for both personal and public use. This project demonstrates the potential of IoT technologies to improve data accessibility and inclusivity in weather monitoring applications. IQ test continue to be one of most reliable tools to measure intelligence skills of the human. The Intelligence Quotient (IQ) tests and the corresponding psychometric explanations dominate both the scientific and popular views about human intelligence. Though the IQ tests have been in currency for long, there exists a gap in what they are believed to measure and what they do. While the IQ tests index the quality of cognitive functioning in selected domains of mental repertoire, the applied settings often inflate their predictive value leading to an interpretive gap.
Website Hosting
Authors: Magar Anand
Published: December 2023

Abstract: This research paper presents an innovative website hosting platform developed. The platform focuses on performance, scalability, and user experience while remaining accessible and affordable for small businesses and individuals. The study outlines the development process, highlights key features, and showcases positive user feedback, contributing to the advancement of web hosting technologies and inspiring the student community.
5G-Smart Diabetes Towards Personalized Diabetes Diagnosis with Healthcare Big Data Clouds
Authors: Biradar Veeresh
Published: December 2023

Abstract: Ongoing advances in remote systems administration and large information innovations, for example, 5G organizations, clinical enormous information examination, and the Web of Things, alongside late improvements in wearable registering and man-made consciousness, are empowering the turn of events and execution of creative diabetes observing frameworks and applications. Because of the long lasting and methodical mischief endured by diabetes patients, planning successful techniques for the conclusion and treatment of diabetes is basic. In view of our exhaustive examination, this article orders those techniques into Diabetes 1.0 and Diabetes 2.0, which display lacks as far as systems administration and knowledge. Subsequently, we want to plan a practical, savvy, and clever diabetes determination arrangement with customized treatment. In this article, we initially propose the 5G-Savvy Diabetes framework, which consolidates the cutting edge advancements, for example, wearable 2.0, AI, and enormous information to produce far reaching detecting and examination for patients experiencing diabetes. Then, at that point, we present the information sharing instrument and customized information examination model for 5G-Savvy Diabetes. Last but not least, we develop a 5G-Smart Diabetes testbed that incorporates big data clouds, smart clothing, and smartphones. Our system is capable of effectively providing patients with personalized diagnosis and treatment recommendations, as demonstrated by the experimental results
Sign Language Detection of English Alphabets for Deaf and Dumb People
Authors: Jaju Raghav
Published: December 2023

Abstract: This research explores the implementation of a robust system for sign language detection designed to facilitate communication for individuals who are deaf and dumb. Leveraging the capabilities of Python, Mediapipe, OpenCV, and Scikit Learn, our proposed system focuses on real-time hand sign recognition of English alphabets. The framework employs Mediapipe for hand landmark detection, enabling precise tracking of hand gestures. OpenCV is utilized for image processing, allowing efficient handling of video streams. The combination of these tools enables the extraction of relevant features from hand signs, forming the basis for our recognition model. The core of our system is built upon the Random Forest algorithm from Scikit Learn, implementing machine learning for the classification of hand signs. This approach ensures adaptability to various hand shapes and orientations, contributing to the versatility of the system. The proposed solution aims to bridge communication gaps for individuals with hearing and speech impairments, empowering them to express themselves through sign language. Through real-time detection and interpretation of hand signs, our system provides a valuable tool for enhancing communication and fostering inclusivity for the deaf and dumb community.
Comparison of Antioxidant Activity of Some Antidiabetic Traditional Medicinal Plants of Madhya Pradesh, India
Authors: Soni Pramila
Published: December 2023

Abstract: Traditional antidiabetic drugs are in use by a majority of patients having type II diabetes, due to their belief in traditional medicines. Here, we report the additional benefits of using such traditional plants in the diabetes therapy, so that these locally available medicines are promoted over synthetic drugs. Ten medicinal plants were chosen for the study, selected based on the traditional knowledge. The plant parts were extracted with water, methanol, ethyl acetate and petroleum ether. Antioxidant activity was determined by analyzing the potential of these extracts to scavenge superoxide, hydroxyl, nitrate, peroxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals, under in vitro conditions as compared to the positive control; ascorbic acid (4 mg ml-1 ). Highest antioxidant activity was shown by extracts of Gymnema sylvestre, followed by Withania somnifera against all free radicals tested.
Navigating COVID-19: AI-Enhanced Chatbots for Instant Health Insights
Authors: Pawar Sahil
Published: December 2023

Abstract: Covid-19 has produced an ongoing epidemic, with over 15.7 million illnesses and over 640,000 deaths as of July 26, 2020. Covid -19 is a highly dynamic and fast shifting scenario, making precise, on- demand information about the disease difficult to come by. In online communities, forums, and social media, you can pose a question and receive an answer from other people in this community. Additionally, you can search through these resources for relevant questions and answers. However, due to the construction of such websites, there is never an endless number of important queries and responses to choose from, and questions that are put up are seldom addressed immediately. For example, recent advances in NLP, predominantly concerning Language Models, have allowed for developing automated bots able to engage in conversation with customers. However, these types of models find little use in modern day health care and their efficacy is not assessed to supply precise, current health care information.
A Review on Blow Fill Seal Machine
Authors: Pacharne Pavan Karbhari , Bhivsane Miss. Ashwini , Sanap Dr Gajanan
Published: December 2023

Abstract: For medical specialty that area unit administered by sure ways in which like pneumonic delivery, plastic ampoules offers several and points over glass ampoules, vials, or syringes. Plastic ampoules area unit manufacture victimisation blow–fill– seal (BFS) technology. within the BFS method plastic extrusion, molding, antiseptic filling in one line operation. not like tiny molecules, biological drug product, like proteins or being antibodies, area unit a lot of directed to degradation throughout process, which can end in degradation of activity or safety issues. The in operation conditions for a BFS method and therefore the nature of plastic ampoules provides several issues to the steadiness and integrity of biological drug product. during this article, the authors discuss issues within the development and producing of biological product victimisation the BFS method, as well as potential productexposure to elevated temperature, needs for leak detection, and packaging systems. They additionally highlight challenges and techniques for BFS method characterization and validation within the context of biopharmaceutical producing
Issues of Power Quality
Authors: Sushma Gillepalli
Published: December 2023

Abstract: In this modern era, the electricity dependence for domestic, commercial and industrial purposes has been increasing day to day. The non-linear loads associated will leads to some of the power quality issues. Such Power Quality Issues viz., voltage sag, Interruptions, spikes in voltage, fluctuations etc. briefly discussed in this paper.