bluuebunny/crossref_metadata_2025 huggingface dataset:
КОРЕКЦІЙНА РОБОТА З ДІТЬМИ З РОЗЛАДАМИ АУТИСТИЧНОГО СПЕКТРА В ІНКЛЮЗИВНОМУ ОСВІТНЬОМУ СЕРЕДОВИЩІ
Authors: Коломійченко Олег
Published: February 2023

У статті розглянуто особливості використання методів візуальної підтримки в корекційній роботі з дітьми з розладами аутистичного спектру в інклюзивному освітньому середовищі. Метою статті є наукове обґрунтування корекційної роботи з дітьми з розладами аутистичного спектру із використанням методів візуальної підтримки. В статті ми використовували наступні методи: аналіз, порівняння та систематизація науково-методичних, вітчизняних та зарубіжних літературних джерел із спеціальної педагогіки та психології.

Результати дослідження переконливо свідчать про переваги методів альтернативної та додаткової комунікації, методу візуального розпорядку дня, використання соціальних історій, глобального читання, допоміжних схем і таблиць, алгоритмів дій у дошкільному та шкільному освітньому процесі. Зазначено, що для альтернативної та додаткової комунікації використовують символи, піктограми, жести, малюнки, фотографії. Методи візуальної підтримки слід використовувати у випадках відсутності мовлення, або у випадках, коли мовлення дитини є незрозумілим для інших людей. Ці методи базуються на сильних якостях дітей з розладом аутистичного спектра: розвиненої зорової пам’яті та спроможності добре сприймати зорову інформацію. Стаття містить практичні рекомендації щодо використання цих методів в корекційній роботі з дітьми з розладами аутистичного спектру для покращення їх поведінки, якості освіти та підготовки до майбутньої професійної діяльності та незалежного життя.

У висновках зазначено, що для успішного функціонування та навчання в інклюзивних групах і класах для таких дітей потрібні спеціальні методи візуальної підтримки. Це методи врегулювання поведінки, що сприяють розвитку самоконтролю та методи навчання. Використання даних методів в інклюзивному освітньому середовищі робить процес навчання ефективним, запобігає негативним проявам поведінки, підвищує якість засвоюваного матеріалу, готовить дитину до майбутньої професійної діяльності, сприяє розвитку самостійності.

Подальше вивчення розглянутої проблеми передбачає розробку системи комплексної корекційної роботи з дітьми з розладами аутистичного спектру в умовах інклюзивного освітнього середовища.
ПОЛІПШЕННЯ ФУНКЦІОНАЛЬНОГО СТАНУ ДІТЕЙ ЗІ СКЛАДНИМИ ПОРУШЕННЯМИ РОЗВИТКУ ЗАСОБАМИ ФІЗКУЛЬТУРНО-ОЗДОРОВЧОЇ ПРОГРАМИ В УМОВАХ ОСВІТНЬО-РЕАБІЛІТАЦІЙНОГО ЦЕНТРУ
Authors: Лещій Наталія
Published: February 2023

Стаття присвячена проблемі застосування засобів фізкультурно-оздоровчої програми для поліпшення функціонального стану та рівня фізичного здоровʼя дітей молодшого шкільного віку зі складними порушеннями розвитку. Стратегічною метою навчання і виховання дітей зі складними порушеннями розвитку є повноцінна інтеграція в суспільство, що дозволить їм нарівні зі здоровими однолітками сприймати інтелектуально-естетичні цінності суспільства. Мета роботи полягає в обґрунтуванні фізкультурно-оздоровчої програми у дітей молодшого шкільного віку зі складними порушеннями розвитку та експериментальному вивченні її ефективності. Методи: для досягнення поставленої мети дослідження використано кoмплекс взаємoпoв’язаних метoдів, серед яких: методи теоретичного рівня дослідження (аналіз, порівняння, індукція, дедукція, систематизація та узагальнення науково-методичної літератури); методи емпіричного рівня (педагогічне спостереження, педагогічний експеримент для визначення ефективності розробленої фізкультурно-оздоровчої програми з дітьми зі складними порушеннями розвитку, фізіологічні методи); методи математичної статистики. Апробація експериментальної фізкультурно-оздоровчої програми відбувалася із залученням 100 дітей молодшого шкільного віку, з них 53 дівчинки та 47 хлопчиків, які методом випадкової вибірки були розподілені на 2 групи – експериментальну та контрольну. Результати. Розроблено фізкультурно-оздоровчу програму для дітей зі складними порушеннями розвитку, що включала раціональне поєднання вправ різного спрямування; дотримання оптимальної їх інтенсивності та тривалості виконання відповідно до індивідуальних особливостей дитини зі складними порушеннями розвитку; вихідного положення; супутніх захворювань та факторної структури загального рівня фізичного здоров’я молодших школярів. Висновки. Проведене дослідження свідчить про те, що у дітей зі складними порушеннями розвитку упродовж педагогічного дослідження вірогідно поліпшилися функціональні можливості кардіореспіраторної системи, про що свідчило збільшення часу затримки дихання на фазі вдиха та видиха, життєвого індексу та фізичної працездатності у хлопчиків і дівчаток  молодшого шкільного віку.
ПІДГОТОВКА ДЕФЕКТОЛОГІЧНИХ КАДРІВ В УКРАЇНІ У 30-Х РОКАХ ХХ СТОЛІТТЯ
Authors: Шевченко Володимир
Published: February 2023

У статті розглядаються питання підготовки в Україні дефектологічних кадрів для спеціальних шкіл в останнє десятиріччя перед Другою світовою війною. Метою статті є висвітлення організації процесу підготовки фахівців відповідного профілю в Україні до роботи з дітьми з особливими освітніми потребами. У дослідженні, для досягнення поставленої мети, були використані методи пошуку, аналізу, систематизації та узагальнення. Автор зазначає, що нова освітня політика радянської влади, яка сформувалася та впроваджувалася у кінці 20-х початку 30-х років, потребувала розширення різних форм підготовки майбутніх дефектологів і підвищення якості їхньої професійної освіти. Соціокультурні умови, що склалися в Україні на початку 30-х років ХХ ст., потребували реформування всієї системи освіти дітей з інвалідністю, внаслідок чого були розроблені необхідні документи. Відповідно, рекомендувалося розширювати підготовку дефектологічних кадрів у вищих педагогічних навчальних закладах і на курсах. Згодом курсова підготовка та підвищення кваліфікації педагогів-дефектологів України для роботи у спеціальних школах проводилася на базі лікарсько-педологічних інститутів фізичної дефективності, лікарсько-педологічного кабінету та кабінетів індивідуальної педагогіки досвідно-педагогічних станцій.

Ретроспективне дослідження дає змогу виокремити особливості підготовки та перепідготовки педагогічних кадрів для потреб спеціальної школи в окреслений період. Внаслідок цих особливостей, як теоретичні, так і практичні аспекти підготовки студентів-дефектологів зводилися до мінімуму, що не відповідало специфіці їхньої майбутньої діяльності, також не було розподілу за напрямками.

Таким чином, проведене дослідження свідчить, що в означений хронологічний період в Україні відбувалося збільшення мережі спеціальних закладів для дітей з особливими потребами, відповідно була необхідність збільшення та розширення кількості закладів для підготовки педагогів-дефектологів. Проте, лише наприкінці 30-х рр. в Україні почалося активне зростання кількості таких закладів і склалася система підготовки фахівців.
K-W-L: A STRATEGY ON IMPROVING STUDENTS’ READING COMPREHENSION
Authors: Amaliani Priska
Published: February 2023

The main purpose of this research was to obtain empirical evidence on the impact of the K-W-L strategy on students’ reading comprehension. The research employed a quasi-experimental design intended to obtain the requisite empirical proof. The population was the students of the eighth grade students of MTs. Daarul Hikmah, Pamulang. To obtain this aim, the research consisted of 44 students selected by purposive sampling. They divided trough two groups, experimental and controlled group. As the system design, the experimental group was taught reading by K-W-L strategy as the treatment while another group was not given the treatment.  The test was performed at the start and end of treatment that called by pre-test and post-test. Moreover, the t-test result of the gained score study, created from the different between pre-test and post-test, showed that the mean of experimental group score was higher than the controlled group. The score difference was 7.27 points. In addition, the value (2-tailed) or p was lower than alpha, p 0.05. This means that the use of the K_W-L strategy was successful in improving the reading comprehension of Descriptive text by the eighth grade students of MTs Daarul Hikmah, Pamulang.
DESIGNING AN ENGLISH VOCABULARY WORKBOOK FOR HOSPITALITY STUDENTS BASED ON CORPUS-BASED APPROACH
Authors: Fauzi Andi Rizki , Suradi Suradi
Published: February 2023

The research about the use of corpus-based approach in teaching English for Specific Purposes (ESP) to improve the students' vocabulary mastery has been conducted by many researchers. However, the product of the materials in teaching and learning vocabulary which laverages the use of corpus is very limited. For that reason, this study is aimed to design a prototype of English vocabulary workbook for Hospitality students based on corpus-based approach in determining the content, task, and activities carried out. This research uses Analysis, Design, Development, Implementation, and Evaluation (ADDIE) model as the procedure to create a valid, practical, and effective English vocabulary workbook for Hospitality students and corpus-based approach will be used in determining the target words, task, and activities in the workbook. Based on the result of analysis using Wilcoxon test,  it can be seen that the Asymp.Sig (2-tailed) is 0.000. As the value of 0.000 is smaller than 0.05, it can be concluded that there is a significant difference between the results of student learning before and after using the workbook developed.
WORD FORMATION IN SELECTED LYRICS WRITTEN BY ASIAN SONGWRITERS
Authors: Handayani Merih , Putri Evi Jovita , Harared Nico
Published: February 2023

The aim of the study is to explore the type of word-formation process in Selected Lyrics Written by Asian Songwriters. The form of this research was a qualitative method thus the result was conducted in descriptive. The data were taken by sorting out the English song written by Asian songwriters which were released around 2018-2021 and have at least 3 million listeners on an online streaming platform then making the transcript of the lyrics. The focus of this research is to find out and analyze word-formation process using Yule's theory (2010) and Plag (2002) as supporting theories. As the result, there are 8 processes of word-formation, and the most prominent lyrics are formed through Inflectional with 45 data then followed by Compounding 27 data, Derivation 25, Multiple Processing 24 data, Clipping 11 data, Blending 8 data then Acronym and Conversion that has 6 data of each.
INTEGRATING TOPIC TYPE STRATEGY TO INCREASE VOCATIONAL HIGHER EDUCATION STUDENTS WRITING SKILL
Authors: Maldin Siska Amelia
Published: February 2023

Teaching English in Vocational Higher Education are designed not only to achieve students’ competence in obtaining English for academic matters but also to achieve skilled aspect for preparing learners in the industrial field, especially in writing skill. Thus, effective strategies should be delivered to achieve the goals of gaining students’ competence in writing skills. One of the strategies implemented is topic types which are expected to enhance students writing skills. This study is designed by using the library research method, which claimed that this topic types strategy might encourage students to generate ideas especially to help them in managing ideas before writing.
AN ANALYSIS OF PROPPIAN’S ARCHETYPES ON CHARACTERS IN ZOOTOPIA MOVIE
Authors: Siregar Liga Sandi , Putri Aulia
Published: February 2023

Watching movie has become as one of activity choices by people in spare time. This phenomenon can be influenced by the way its presented. As one of literary works, movie has fiction elements, intrinsic elements and extrinsic elements.Intrinsic element is the elements that build the literary work itself. The elements consist of plot, theme, background, character, and point of view. Character has an important role in building a fictional story.A character can be divided into some categories, they are protagonist character, antagonist character, typical character, supporting character,neutral character, etc. a characters can be created by use the seven sphere of acttion which are the Hero, the the Villain, the Donor, the Helper, the Princess, the Dispatcher and the False Hero.Therefore, this research aims focused on analyzing the seven archetypes in Vladimir Propp’s Morphology of the Folktale theory appear in Zootopiamovie. Finally, the findings show that there are 6 out of 7 archetypes that appeared in this movie. The Helper was the most dominant Archetypes that showed in the film with 4 data, followed by Hero, Villain, Princess, and Dispatcher with 2 data and the least dominance Archetypes that showed in the movie was Donor with 1 data.
THE EFFECT OF SCHOOL FACILITIES ON STUDENTS’ LEARNING MOTIVATION ON ENGLISH
Authors: Hardiana Nabilla Dwi , Aisyah Natasya , Harahap Natasya Herza
Published: February 2023

School facilities are a very important tool in supporting learning in schools. Facilities will be needed by teachers and students in teaching and learning because the facilities will increase students' learning motivation, with complete facilities will also support the performance of teachers in delivering material to students. The purpose of this study is to observe school facilities, especially MTS Ali Imron and see the effect of students' learning if the school facilities are inadequate, especially in English subjects. The case study in this study was conducted at MTS Ali Imron Medan. The method in this study uses a qualitative method by observing schools and conducting interviews with English teachers at MTS Ali Imron Medan.
TRANSLATION TECHNIQUES USED BY ENGLISH THIRD SEMESTER STUDENTS OF UNIVERSITY OF RIAU KEPULAUAN
Authors: Ashari Erwin , Harahap Marida Hannum , Shalehoddin Shalehoddin
Published: February 2023

Translation is the transferring meaning of the text from source language in which to equivalent text in target language that communicates similar messages by changing structure without changing meaning. The qualitative descriptive method as the research design of this study which aimed to find out translation techniques used by English third semester students in translating a narrative text entitled “Telaga Warna” from English into Indonesian and to describe the dominant technique used by the students in translating the text. The collecting of the data collected taken from the result translation of narrative text from English into Indonesian by 14 participants of English third semester students. In this study, the data analyzed based on translation techniques of Molina and Albir (2002) theory. Based on data analysis, it was found that the translation techniques of narrative text entitled “Telaga Warna” from English into Indonesian done by English third semester students of University of Riau Kepulauan uses fourteen (14) translation techniques found in 1302 data while translating the text. The translation techniques were namely literal translation, calque, reduction, amplification, discursive creation, linguistic amplification, established equivalent, particularization, transposition, linguistic compression, modulation, borrowing, variation, and generalization. The most dominant technique of translation used by students was literal translation techniques
Pengaruh Sosialisasi Perpajakan, Pengetahuan Peraturan Perpajakan dan Kualitas pelayanan Terhadap Kepatuhan Wajib Pajak Kendaraan Bermotor di Daerah Banyuasin
Authors: Aziz Melsi , Widyanti Yeni
Published: February 2023

The purpose of this study was to determine the effect of motor vehicle tax compliance. In his research, the authors studied "The Influence of Tax Socialization, Knowledge of Tax Regulations and Service Quality on Motor Vehicle Taxpayer Compliance in the Banyuasin Region" who make vehicle tax payments. the object used in this study is the Banyuasin Samsat tax service office. it is known that the number of vehicle taxpayers is 3,164 samples in this study using the non-probability sampling method with 100 respondents from motor vehicle taxpayers at the Banyuasin Samsat Service Office in 2023. The data used is primary data through a questionnaire containing respondents' answers using the Likert method. Data analysis used in this study is multiple linear regression analysis. Meanwhile, based on the F test, it can be concluded that tax socialization has a negative effect on motor vehicle taxpayer compliance, while knowledge of tax regulations has a positive effect on motor vehicle taxpayer compliance, as well as service quality has a positive effect on motor vehicle taxpayer compliance. This shows that the independent variables together are able to explain the dependent variable.
Monkeypox: The New Pandemic of 2022
Authors: Souza Arthur Araújo de , Albuquerque Geovana Borba de , Dantas Luanna Karina Marinho de Assis , Duarte Marvin Gonçalves , Moraes Luísa Montenegro Brayner de , Silva Luciano Barreto , Cunha Rodolfo Scavuzzi Carneiro
Published: February 2023

This literature review addresses monkeypox, an infectious disease caused by the Monkeypox virus that belongs to the genus Orthopoxvirus and to the family Poxviridae, the same as the human smallpox virus. It had its first case registered in Congo in 1970. After almost 40 years, with no reported case, in 2017 it re-emerged in Nigeria. With the absence of mass vaccination and its transmission occurring through direct contact with people infected through close and prolonged exposure to droplets or other respiratory secretions, this virus has already originated in more than 44 countries, causing a new global pandemic. With a low mortality rate, which can reach between 3% and 6%, its symptoms are very similar to those observed in patients with smallpox, although they are clinically less severe. Thus, the present work aimed to study the characteristics and general aspects of monkeypox, in order to take measures to prevent and promote this disease.
Freya: An educational MATLAB GUI-based tool for generalized Fourier series
Authors: Macedo Humberto Gimenes , Oliveira Virginia Klausner de , Gomes Anna Karina Fontes , Fernandes Francisco Carlos Rocha
Published: February 2023

The Fourier analysis is a very powerful mathematical tool to decompose functions into their frequency components. Due to this, it has applications in a wide variety of fields inside the realm of science and engineering. As usual, this theory starts with a discussion about the trigonometric Fourier series, the expansion of a function in terms of sines and cosines, and then is generalized in the sense that other functions rather than the trigonometric ones can be used as an orthogonal basis, as the eigenfunctions of some specific Sturm-Liouville problems, such as Bessel functions and Legendre polynomials. In this direction, we present the so- called Freya, an educational graphical user interface (GUI) for the generalized Fourier series developed using the interactive MATLAB (MATrix Laboratory) App Designer environment. We aim to provide a user-friendly tool as a learning aid system for students to gain a comprehensive understanding of the subject as well as for teaching.
Seleção de pacientes ao transplante pulmonar: uma revisão integrativa de literatura
Authors: Rosa Francisca Rafaela Pereira de Amorim Castro , Gomes Maria Jacilene de Araújo , Menezes Ana Gilca Gonzaga de , Resende Grazielle Borges de Oliveira , Cunha Iane Andrade Maciel Feldner , Peixoto Sara Rosa , Cabral Rodrigo Fernandes Rapozo Pereira
Published: February 2023

Atualmente, as principais indicações de transplante pulmonar em todo mundo são doença pulmonar obstrutiva crônica (DPOC), fibrose pulmonar, fibrose cística, deficiência de alfa-1-antitripsina (alfa-1), hipertensão arterial pulmonar idiopática, bronquiectasias, retransplante, sarcoidose e lesão pulmonar grave causada pela COVID-19, sendo que esses candidatos devem demonstrar conhecimento em relação ao procedimento, boa aderência ao tratamento médico realizado, estrutura psicossocial e suporte familiar adequados. Ademais, a adequada avaliação das contraindicações contribui para menor ocorrência de desfechos clínicos desfavoráveis não relacionados ao enxerto, beneficiando os pacientes com maior chance de sucesso e, assim, melhorando a sobrevida geral com o tratamento. Dentre as contraindicações absolutas, destacam-se câncer de pulmão, disfunção cardíaca não relacionada à doença pulmonar, disfunção orgânica significativa de qualquer outro órgão nobre, infecções pelo vírus B e C da hepatite, tuberculose pulmonar ativa e deformidade grave da caixa torácica. Ademais, dentre as contraindicações relativas, tem-se a idade maior que 65 anos, instabilidade clínica grave, infecção pelo vírus HIV, obesidade, osteoporose severa e doenças sistêmicas descompensadas.
Pembuatan alat deteksi suhu tubuh untuk jamaah masjid sebagai pencegahan penyebaran COVID-19 di rumah ibadah
Authors: Kridoyono Agung , Sudaryanto Aris , Sasongko Dimas , Wali Muhammad , Yanto Budi , Ogidia Bella Novica
Published: February 2023

Pandemi mengakibatkan dampak yang luar biasa terhadap berbagai sektor kehidupan, sektor ekonomi pariwisata, perdagangan dan investasi, bahkan sektor keagamaan juga terdampak. Selama pandemi, kegiatan ibadah menjadi sangat terbatas seperti halnya kegiatan masyarakat yang lain. Hal ini menjadi kondisi yang dilematis, disatu sisi masyarakat ingin kegiatan ibadah kembali semarak, tapi disisi lain juga harus taat terhadap protokol kesehatan. Dalam rangka mengatasi permasalahan tersebut, pengabdi berinisiatif melakukan kegiatan pengabdian yang berfokus pada pembuatan alat pengukur suhu tubuh tanpa sentuh untuk jamaah masjid ini. Pendekatan yang dilakukan pada kegiatan ini adalah Participatory Action Research (PAR) dengan objek utama adalah jamaah Masjid At Thoharoh Desa Tumpang Kabupaten Malang. Diharapkan hal tersebut dapat menjadi solusi agar aktivitas ibadah tetap dijalankan serta mematuhi protokol kesehatan untuk mencegah penyebaran COVID-19. Adapun fungsional alat telah diuji dan dapat bekerja 100%, sedangkan hasil pengukuran suhu pada alat hanya selisih 0.32% dengan pengukuran suhu menggunakan thermogun. Artinya alat yang dibuat telah dapat bekerja sebagaimana mestinya dengan tingkat akurasi yang baik.
Inventivitas pengrajin batu alam dalam mewujudkan desa wirausaha
Authors: Yuliati Lilis , Komariyah Siti , Shulthoni Mochammad , Sutantio Raden Alamsyah
Published: February 2023

Terdapat beberapa permasalahan yang muncul pada proses produksi Batu Piring di Desa Sumberkalong Kecamatan Kalisat Kabupaten Jember, seperti minimnya penggunaan teknologi pada proses produksi dan sistem pemasaran yang belum optimal. Dengan demikian, program ini bertujuan untuk memberikan solusi terkait dengan proses produksi dengan mengintegrasikan peranan teknologi melalui mesin pemotong batu piring untuk Mitra. Selain itu, Tim Pelaksana juga memberikan sosialisasi dan penyuluhan tentang pemasaran online atas produk yang dihasilkan untuk memperluas jangkauan dan akses pasar. Metode Participatory Rural Appraisal (PRA) digunakan dalam mencapai tujuan program ini. Hasil dari program ini berupa pemberian bantuan modal usaha berupa alat pemotong batu piring dengan Mitra Pak Juhadi selaku pengrajin batu piring dari Dusun Plalangan Desa Sumberkalong Kecamatan Kalisat Kabupaten Jember. Inventivitas pengrajin batu piring berupa pemakaian mesin pemotong batu memberikan kemudahan bagi Mitra dalam proses produksi dan peningkatan kuantitas dan kualitas produk. Selain itu, dapat mendiversifikasi produk kerajinan batu piring dimana tidak hanya sebagai hiasan dinding namun juga lantai dengan kualitas produk yang lebih rapi dan dapat memberikan nilai ekonomis yang lebih tinggi.
Analisis kelayakan ekonomi produk sanitasi dalam upaya self-sufficiency
Authors: Dewi Luthfi Kurnia , Cahyani Chandrawati , Nurhadianty Vivi , Sarosa Aji Hendra
Published: February 2023

Kegiatan pondok pesantren tidak lepas dari penggunaan produk sanitasi untuk menjaga kesehatan dan kebersihan. Salah satu produk sanitasi yaitu hand sanitizer. Tujuan dari kegiatan pengabdian ini yaitu melatih analisis kelayakan ekonomi produk sanitasi dalam upaya self-sufficiency di pondok pesantren Bahrul Maghfiroh Malang. Melalui pengabdian ini diharapkan kesehatan dan kebersihan santri terjaga dan dapat menciptakan pondok mandiri secara finansial. Pengabdian ini dilakukan daring dengan memberikan pelatihan formulasi hand sanitizer dan analisis kelayakan ekonomi meliputi perhitungan harga jual produk dan kriteria investasi. Berdasarkan simulasi hasil perhitungan, didapatkan harga jual hand sanitizer kemasan 100 ml yaitu Rp 11.528,00 dengan laba 5% dari harga pokok penjualan. Dengan interest rate (IR) sebesar 4,25%, didapatkan nilai NPV sebesar Rp 235.841.940,31 dan IRR sebesar 58,82%, dimana investasi produk sanitasi ini dikategorikan visible (layak) karena NPV > 0 dan IRR > IR. ROI yang didapatkan sebesar 94,89% dengan PBP selama 1,05 tahun. Capaian pelaksanaan kegiatan pengabdian ini dapat dilihat dari kepuasan mitra dengan hasil kuesioner rata-rata kepuasan sekitar 74% responden menjawab setuju terhadap kebermanfaatan kegiatan ini. Oleh karena itu, kegiatan analisis kelayakan ekonomi produk sanitasi perlu dilakukan secara kontinyu dan bisa dikembangkan untuk produk sanitasi yang lain.
PENGEMBANGAN MEDIA INTERAKTIF DAN IMPLEMENTASI APLIKASI MYBIDAN SEBAGAI UPAYA UNTUK PENURUNAN ANGKA STUNTING
Authors: Izzati Berlian Maulidya , Fajrillah Asti Amalia Nur , Fauzi Rahmat , Febriyani Widia
Published: February 2023

According to the report on the implementation of the Integration of the National Socio-Economic Survey (Susenas), the prevalence of stunting in the Temanggung district is 25.79%, which is higher than the standard given by WHO, which is 20%. Stunting is a condition where toddlers have a length or height that is less than their age. The long-term impact of stunting is the disruption of physical, mental, intellectual, and cognitive development. In this regard, Telkom University in collaboration with the Temanggung DPPPAPPKB (Dinas Pemberdayaan Perempuan, Perlindungan Anak, Pengendalian Penduduk dan Keluarga Berencana ) plans to increase community knowledge of stunting and collaboration in supporting the Temanggung Regency government program by developing an interactive educational platform, as well as a collaboration platform that can facilitate communities and institutions to participate in helping prevent stunting in Temanggung Regency. This activity expected that the implementation of this application can assist in increasing the effectiveness and efficiency of delivering messages and campaigns against stunting problems, one of the programs belonging to the Temanggung DPPPAPPKB.
Phytochemical profiling and heavy metals composition of aqueous and ethanol extracts of Anogeissus leiocarpus
Authors: DAHIRU Muhammad Mubarak , BADGAL Enoch Buba , MUSA Neksumi
Published: February 2023

Objective: The present study aimed to investigate the phytochemical and heavy metals components of A. leiocarpus considering its applications in ethnomedicine.

Material and Method: The phytochemical components were determined qualitatively and quantitatively gravimetrically, while component identification was done using (Gas spectrometer-mass spectrometer (GC-MS) technique. Heavy metals were quantified by atomic absorption spectrophotometer.

Result and Discussion: Saponins and flavonoids were detected in the aqueous extracts in concentrations of 10.22% ±0.48, and 38.67% ±0.17 respectively, and concentrations of 17.37% ±0.65 and 19.63% ±0.60 respectively in the ethanol extract.. GC-MS analysis identified 16 and 26 compounds in the aqueous and ethanol extracts respectively. In the aqueous extract, 5-Hydroxymethylfurfural, 1,2,4-Benzenetriol, and cis-Vaccenic acid had the highest peak areas of 46.24, 17.12, and 15.13% respectively, while in the ethanol extract 5-Hydroxymethylfurfural (14.40%),1,2,3-Benzenetriol (12.29%) and -methoxybenzene-1,4-diol (7.54%) were the highest. Chromium (0.548 ppm ±0.030) was detected only in the aqueous concentration, while Cadmium had a concentration of 0.002 ±0.001 and 0.006 ppm ±0.002 in the aqueous and ethanol extract respectively. Lead was present with aqueous and ethanol extracts concentrations of 0.096 ±0.020 and 0.096 ppm ±0.040 respectively. Conclusively, the present study agrees with the claims for the traditional application of the plant in folkloric medicine to manage different ailments.
Role of Coagulation Factor Concentrates in the Operating Room
Authors: Toh Cheng-Hock , Alhamdi Yasir
Published: February 2023

The use of fresh frozen plasma, cryoprecipitate, and platelets has been the mainstay of approaches to correct coagulopathies that can arise in the perioperative setting. Limitations include the time delay from obtaining results of coagulation screens to the availability of thawed fresh frozen plasma and the potential of fluid overload. With advances in both global haemostatic testing and concentrates of coagulation factors, there are increasing opportunities for innovative practice. However, there remains a paucity of studies that can provide good quality, unbiased evidence. These issues are elaborated here to form the basis for future study.
The Liver Meeting 2014
Authors: Charles Caroline
Published: February 2023

Rapid developments in clinical research on the hepatitis C virus infection in the last few years have led to the development of direct-acting antivirals, such as sofosbuvir, simeprevir (both of which have been approved in the US and Europe since 2014), and daclatasvir, which was approved in Europe only in 2014. These new drugs generated a change of paradigm from interferon-based therapies, as the former require shorter treatment durations and provide high cure rates with acceptable toxicity. The 65th American Association for the Study of Liver Diseases (AASLD) Annual Meeting, The Liver Meeting® 2014, took place in Boston, Massachusetts, on 7th-11th November. This review will summarise the highlights of this meeting within the context of pivotal clinical trials and real-life data on this rapidly evolving treatment environment, which will assist clinicians in selecting the most appropriate regimen for patients.
How Bioresorbable Vascular Can Be Beneficial for Patients in the Long-Term
Authors: Serra Antonio , Ribichini Flavio , West Nick
Published: February 2023

Coronary artery disease (CAD) is the leading cause of mortality in patients ≥60 years old worldwide, and may result in stable angina, acute coronary syndromes (unstable angina or acute myocardial infarction), congestive heart failure, cardiac arrhythmia, or sudden death. A variety of medical therapies can treat the symptoms and arrest progression of CAD, but mechanical revascularisation of affected arteries is widely employed to ameliorate the symptoms of angina and improve prognosis, particularly in situations of multivessel disease, significant ischaemia, and in the setting of acute myocardial infarction.

Rates of surgical revascularisation by coronary artery bypass graft surgery have gradually fallen over recent decades, with a concomitant rise in percutaneous coronary intervention procedures. Such minimally invasive techniques have evolved considerably in the last four decades, from plain old balloon angioplasty, through initial use of bare-metal stents to mitigate acute vessel closure, to the advent of drug-eluting stents designed and proven to reduce rates of restenosis. Bioresorbable vascular scaffolds/bioabsorbable stents are a new and promising generation of intravascular devices that may potentially circumvent many of the problems associated with such permanent metallic implants. This article will review available clinical trial and real-life data on the Absorb™ Bioresorbable Vascular Scaffold (Abbott Vascular, Santa Clara, California, USA), and highlight the potential utility of this novel class of devices in the management of patients with CAD.
Primary Focal Segmental Glomerulosclerosis: Why Are Pieces of This Puzzle Still Missing?
Authors: Trimarchi Hernán
Published: February 2023

Focal segmental glomerulosclerosis (FSGS) can be classified as primary or secondary. Moreover, many causes of primary FSGS have been identified in recent years. In this regard, genetic circulating permeability factors and the abnormal podocyte expression of co-stimulatory molecules have been reported. However, the classification of this entity remains difficult to understand, mainly due to the fact that it describes a morphologic pattern of scarring. FSGS is a histological pattern shared by almost all the glomerulonephritides that describes a podocyte lesion and not a disease. Therefore, it should be reclassified according to the new pathophysiological findings and the biomarkers encountered in each triggered pathway.
Tubular Handling of Uric Acid and Factors Influencing Its Renal Excretion: A Short Review
Authors: Bruno Cosimo Marcello , Pricoco Gabriele , Cantone Damiano , Marino Elisa , Bruno Francesca
Published: February 2023

In this review, the authors briefly examine the most recent evidence concerning the role of several proteins involved in tubular urate transport. They also analyse the influence of extracellular volume, electrolyte disorders, acid-base imbalance, and insulin-resistance on renal clearance of uric acid.
Treating the Diabetic Hypertensive: Consensus and Differences
Authors: Rahman Abdul Rashid
Published: February 2023

Hypertension and diabetes commonly coexist. Both are major modifiable risk factors for cardiovascular diseases. There has been a substantial shift in the recommendations of several expert committees on the management of hypertension in diabetics. It was once unanimously agreed by almost all major guidelines that the threshold for initiating diabetic patients with antihypertensive therapy is when blood pressure is >130/80 mmHg. The blood pressure target for treatment was also unanimously agreed to be <130/80 mmHg. These recommendations were, however, based on expert opinions and not on findings from major randomised controlled trials.

Since then, there have been several randomised controlled trials looking at blood pressure-lowering in the diabetic population. These include the ADVANCE and ACCORD, and a subanalysis of the INVEST trials. Together with the earlier UKPDS and HOT trials, one would expect there to be more agreement in the most recent recommendations, but in fact the opposite is the case. There are now two different systolic targets (<130 mmHg and <140 mmHg) and three different diastolic targets (<90 mmHg, 85 mmHg, and <80 mmHg). The reason for this involves the choice of trials included in the recommendation, and the interpretation of results from these trials by various guideline committees.

The recommendation for diabetic hypertensives will be more consistent if future trials begin by asking a relevant research question that has not yet been answered: does treating diabetics with different thresholds of blood pressure levels impact on clinical outcomes? The trial must not only determine a primary research question, but it must also be adequately powered to answer it. Only when this question is answered should the next questions be asked. Does it matter how blood pressure is lowered? And are some drugs better than others? In the meantime, guideline committees should try to narrow the gap in recommendations, particularly if the guidelines originate from the same country or region.
Clinical Relevance of Cerebral Autoregulation Following Spontaneous Intracerebral Haemorrhage
Authors: Cartaxo Patriota Gustavo , Ferreira de Andrade Almir , Rodrigo Belon Alessandro , Bor-Seng-Shu Edson , Silva Paiva Wellingson , Jacobsen Teixeira Manoel
Published: February 2023

Hypertensive intracranial haemorrhage is a common neurological emergency in clinical practice. The presence of an intracranial lesion of expansive focal nature can compress vascular structures and cause ischaemic effects. It is very common for these patients to have hypertensive peaks at admission, which may progress to rebleeding and neurological worsening. The safety of blood pressure reduction in patients with hypertension and intracranial haematomas is still a debatable subject due to lack of studies on cerebral autoregulation in this situation. The aim of this study is to discuss cerebral autoregulation in patients with spontaneous intracerebral haemorrhage based on scientific and personal evidence.
Sufficient Condition for the Existence of an Additional Zone in Singularly Perturbated Second-Order Boundary Problem
Authors: Omaralieva G.
Published: February 2023

Studies the Dirichlet, Neman and Robin boundary value problems for a singularly perturbed linear inhomogeneous second order ordinary differential equation. The considered boundary value problems have three features: the singular presence of a small parameter; the solution of the corresponding unperturbed equation has a k order pole and an additional boundary layer. The singular presence of a small parameter generates the classical boundary layer, and the singular point of the corresponding unperturbed equation generates the second boundary layer. As a result, we get a double boundary layer. A sufficient condition for the existence of an additional boundary layer is found.
Momordica charantia L. Introduction
Authors: Gasimov H. , Ganbarov D. , Huseynov H. , Babayev Ya. , Seidov M.
Published: February 2023

The article deals with the introduction of Momordica charantia L. plant in Nakhchivan. This plant was discovered to be a new species for the flora of the Nakhchivan. Momordica charantia L. has fully adapted to the soil and climatic conditions of the area and has completed its vegetation period. The seeds of the plant were obtained, and it was recommended to use them taking into account the farming characteristics of the species.
Diversified Farming Systems
Authors: Erlygina E. , Shtebner S.
Published: February 2023

The paper considers industrial methods of agriculture, as a result of which environmental damage is caused, waterways are polluted, dead zones are created in the oceans, habitat biodiversity is destroyed, toxins are released into the food chain, endangering the health of the population due to outbreaks of diseases and exposure to pesticides. Diversification of the farming system will help to increase the efficiency of resource use, reduce the number of pests and diseases, diversify income sources and increase the sustainability of production.
New Trends and Prospects for the Development of the North-South International Transport Corridor
Authors: Vydashenko L. , Vydashenko P.
Published: February 2023

Russia’s participation in the formation of corridors in international traffic has become an important state task in recent years. In the context of sanctions from the EU and the US, the use of the usual directions of cargo transportation has become more complicated. Russia has become the leader in terms of the number of sanctions imposed against it, their main goal is to cause significant damage to the country’s economy. Against this background, serious logistical restrictions have arisen, and the routing of cargo flows has generally changed. It is no longer possible to count on the previous routes of cargo flows, they need to be reoriented to other routes. One of such tasks will be the implementation of the North-South ITC project. This route, which starts in St. Petersburg and ends in the port of Mumbai (India), is designed to improve logistics between the Russian Federation and the countries of the Persian Gulf and South Asia. An analysis of the current state of the North-South international transport corridor (NS ITC) is given. The North-South Corridor is one of the most important historical corridors connecting Europe and Russia with Iran and the countries of South Asia. The North-South ITC will allow to restore some transport chains and increase cargo turnover, even taking into account the restrictions and sanctions imposed by the US and the EU. The North-South transport corridor can also solve the fundamental problem of our export competitiveness in the growing markets of India and China.
Criminal Liability of Legal Entities in the Kyrgyz Republic Under the Criminal Code of the Kyrgyz Republic Dated February 2, 2017, no. 19: The Need for Identification or Another Planned Sabotage?
Authors: Imankulov T. , Asilbekov A.
Published: February 2023

The article is devoted to the analysis of the institution of measures of criminal law in relation to legal entities that existed in the Criminal Code of the Kyrgyz Republic dated February 2, 2017, no. 19 due to the criminal law reform of 2012-2020. allegedly relying on the concepts and concepts developed by the law of both the European Union and international law, but not once applied in any criminal case in the Kyrgyz Republic for the entire period of validity of this Criminal Code (from January 1, 2019 to the middle November 2021), when, as a result of the adoption of the new Criminal Code of the Kyrgyz Republic (enacted by the Law of the Kyrgyz Republic of October 28, 2021 No. 126), this institution was liquidated. Based on the analysis of the history of the development of the institution of criminal liability of legal entities under the laws of other countries, international conventions, the authors come to the conclusion that it is absolutely inapplicable, groundless, illegal to include legal entities as subjects of quasi-criminal liability and punishment in the Criminal Code of the Kyrgyz Republic. The authors propose measures to combat such initiatives and “reforms” of criminal law in order to avoid collapse, paralysis of the law enforcement system, similar to the one that arose in 2020 inthe Kyrgyz Republic due to the new Criminal, Criminal Procedure and other codes.
Multiple and Transitive Meanings in Simple Verbs
Authors: Isakova T. , Orozbekova Y. , Muratbaeva K.
Published: February 2023

This article considers the presentation of compound verbs used in plural or transitive meanings in the language of mini epics, and the structure of simple verbs in comparison with verbal phraseological and combinations in plural or transitive meanings. Research objectives: analysis of simple verbs in the language of the epic, close or similar both in meaning and in sound construction, in works and used as active language units in the artistic description and narration of events, scenes, actions and thoughts of characters. Research materials and methods: a scientific analysis of simple verbs, which are used in plural and transitive meanings and acting as active language units in the narrative, was carried out. Research results: it was studied that some primitive verbs were used in different ways in independent semantic differences or in repetitive situations. Conclusions: verbs with a simple structure are often used in the language of epic works in transitional meanings and serve as active language units in the artistic description and narration of events, scenes, actions of characters, thoughts.
‘Believers in Biology’: A Co-ordinated Effort to Disrupt the 2022 Census
Authors: Pedersen Sarah
Published: February 2023

This article investigates the attempt by some gender-critical Scots, led by organisations such as For Women Scotland, to disrupt the administration of the 2022 census in Scotland. They used their census returns to register a protest around guidance relating to the Sex question and around the wider issue of the Scottish Government’s plans to reform the Gender Recognition Act. Protestors used social media to share images of their protest on the census forms over the whole census period, meaning that potential protesters were more likely to choose to protest because they saw a growing number of others sharing what they had done. It is suggested that this protest has contributed, and will continue to contribute, to costs relating to the administration of the census and the processing of census data, including the production and administration of paper census forms; the extension of the deadline for completion of the census; and the ability to use machines to read and process the data. Their action was linked by many protesters to the actions of the suffragettes in relation to the 1911 census, with the expectation that their protests would be visible in 100 years’ time. However, data-protection policies mean many of their actions will not be recorded.
Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus
Authors: Low Hui Ching , Chilian William M. , Ratnam Wickneswari , Karupaiah Tilakavati , Md Noh Mohd Fairulnizal , Mansor Fazliana , Ng Zhi Xiang , Pung Yuh Fen
Published: February 2023

Type 2 Diabetes Mellitus is a major chronic metabolic disorder in public health. Due to mitochondria’s indispensable role in the body, its dysfunction has been implicated in the development and progression of multiple diseases, including Type 2 Diabetes mellitus. Thus, factors that can regulate mitochondrial function, like mtDNA methylation, are of significant interest in managing T2DM. In this paper, the overview of epigenetics and the mechanism of nuclear and mitochondrial DNA methylation were briefly discussed, followed by other mitochondrial epigenetics. Subsequently, the association between mtDNA methylation with T2DM and the challenges of mtDNA methylation studies were also reviewed. This review will aid in understanding the impact of mtDNA methylation on T2DM and future advancements in T2DM treatment.
Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health
Authors: Ung Choong Yong , Correia Cristina , Billadeau Daniel Denis , Zhu Shizhen , Li Hu
Published: February 2023

Despite the promising advances in regenerative medicine, there is a critical need for improved therapies. For example, delaying aging and improving healthspan is an imminent societal challenge. Our ability to identify biological cues as well as communications between cells and organs are keys to enhance regenerative health and improve patient care. Epigenetics represents one of the major biological mechanisms involving in tissue regeneration, and therefore can be viewed as a systemic (body-wide) control. However, how epigenetic regulations concertedly lead to the development of biological memories at the whole-body level remains unclear. Here, we review the evolving definitions of epigenetics and identify missing links. We then propose our Manifold Epigenetic Model (MEMo) as a conceptual framework to explain how epigenetic memory arises and discuss what strategies can be applied to manipulate the body-wide memory. In summary we provide a conceptual roadmap for the development of new engineering approaches to improve regenerative health.
A new approach to deposit homogeneous samples of asbestos fibres for toxicological tests in vitro
Authors: Della Ventura Giancarlo , Rabiee Ahmad , Marcelli Augusto , Macis Salvatore , D’Arco Annalisa , Iezzi Gianluca , Radica Francesco , Lucci Federico
Published: February 2023

In this paper we describe the results obtained with a novel method to prepare depositions of asbestos fibres for toxicological tests in vitro. The technique is based on a micro-dispenser, working as an inkjet printer, able to deposit micro-sized droplets from a suspension of fibres in a liquid medium; we used here a highly evaporating liquid (ethanol) to reduce the experimental time, however other solvents could be used. Both the amount and spatial distribution of fibres on the substrate can be controlled by adjusting the parameters of the micro-dispenser such as deposition area, deposition time, uniformity and volume of the deposited liquid. Statistical analysis of images obtained by optical and scanning electron microscopy shows that this technique produces an extremely homogeneous distribution of fibers. Specifically, the number of deposited single fibres is maximized (up to 20 times), a feature that is essential when performing viability tests where agglomerated or untangled fibrous particles need to be avoided.