bluuebunny/crossref_metadata_2025 huggingface dataset:
The BIRDIES Experiment: Measuring Beryllium Isotopes to Resolve Dynamics in the Stratosphere
Authors: Wharton Sonia , Hidy Alan J. , Ehrmann Thomas S. , Zhu Wenbo , Skinner Shaun N. , Beydoun Hassan , Cameron-Smith Philip J. , Repasch Marisa , Gunawardena Nipun , Lee Jungmin M. , Visser Ate , Griffin Matthew , Maddren Samuel , Oerter Erik
Published: December 2024

Cosmogenic beryllium-10 and beryllium-7, and the ratio of the two (10Be/7Be), are powerful atmospheric tracers of stratosphere–troposphere exchange (STE) processes; however, measurements are sparse for altitudes well above the tropopause. We present a novel high-altitude balloon campaign aimed to measure these isotopes in the mid-stratosphere called Beryllium Isotopes for Resolving Dynamics in the Stratosphere (BIRDIES). BIRDIES targeted gravity waves produced by tropopause-overshooting convection to study their propagation and impact on STE dynamics, including the production of turbulence in the stratosphere. Two custom-designed payloads called FiSH and GASP were flown at altitudes approaching 30 km to measure in situ turbulence and beryllium isotopes (on aerosols), respectively. These were flown on nine high-altitude balloon flights over Kansas, USA, in summer 2022. The atmospheric samples were augmented with a ground-based rainfall collection targeting isotopic signatures of deep convection overshooting. Our GASP samples yielded mostly negligible amounts of both 10Be and 7Be collected in the mid-stratosphere but led to design improvements to increase aerosol capture in low-pressure environments. Observations from FiSH and the precipitation collection were more fruitful. FiSH showed the presence of turbulent velocity, temperature, and acoustic fluctuations in the stratosphere, including length scales in the infra-sonic range and inertial subrange that indicated times of elevated turbulence. The precipitation collection, and subsequent statistical analysis, showed that large spatial datasets of 10Be/7Be can be measured in individual rainfall events with minimum terrestrial contamination. While the spatial patterns in rainfall suggested some evidence for overshooting convection, inter-event temporal variability was clearly observed and predicted with good agreement using the 3D chemical transport model GEOS-CHEM.
A Snow-Based Hydroclimatic Aggregate Drought Index for Snow Drought Identification
Authors: Bazrkar Mohammad Hadi , Zamani Negin , Chu Xuefeng
Published: December 2024

Climate change has increased the risk of snow drought, which is associated with a deficit in snowfall and snowpack. The objectives of this research are to improve drought identification in a warming climate by developing a new snow-based hydroclimatic aggregate drought index (SHADI) and to assess the impacts of snowpack and snowmelt in drought analyses. To derive the SHADI, an R-mode principal component analysis is performed on precipitation, snowpack, surface runoff, and soil water storage. Then, a joint probability distribution function of drought frequencies and drought classes, conditional expectation, and k-means clustering are used to categorize droughts. The SHADI was applied to the Red River of the North Basin (RRB), a typical cold climate region, to characterize droughts in a mostly dry period from 2003 to 2007. The SHADI was compared with the hydroclimatic aggregate drought index (HADI) and U.S. drought monitor (USDM) data. Cluster analysis was also utilized as a benchmark to compare the results of the HADI and SHADI. The SHADI showed better alignment with cluster analysis results than the HADI, closely matching the identified dry/wet conditions in the RRB. The major differences between the SHADI and HADI were observed in cold seasons and in transition periods (dry to wet or wet to dry). The derived variable threshold levels for different categories of drought based on the SHADI were close to, but different from, those of the HADI. The SHADI can be used for short-term lead prediction of droughts in cold climate regions and, in particular, can provide an early warning for drought in the warming climate.
Stepanov-like Pseudo S-Asymptotically (ω, c)-Periodic Solutions of a Class of Stochastic Integro-Differential Equations
Authors: Kostić Marko , Koyuncuoğlu Halis Can , Velinov Daniel
Published: December 2024

The study of long-term behavior in stochastic systems is critical for understanding the dynamics of complex processes influenced by randomness. This paper addresses the existence and uniqueness of Stepanov-like pseudo S-asymptotically (ω,c)-periodic solutions for a class of stochastic integro-differential equations. These equations model systems where the interplay between deterministic and stochastic components dictates the overall dynamics, making periodic analysis essential. The problem addressed in this study is the lack of a comprehensive framework to describe the periodic behavior of such systems in noisy environments. To tackle this, we employ advanced techniques in stochastic analysis, fixed-point theorems and the properties of L1- and L2-convolution kernels to establish conditions for the existence and uniqueness of mild solutions under these extended periodicity settings. The methodology involves leveraging the decay properties of the operator kernels and the boundedness of stochastic integrals to ensure well-posedness. The major outputs of this study include novel results on the existence, uniqueness and stability of Stepanov-like pseudo S-asymptotically (ω,c)-periodic solutions, along with illustrative example demonstrating their applicability in real-world stochastic systems.
Laplacian Spectrum and Vertex Connectivity of the Unit Graph of the Ring \({ℤ_{p^{r}q^{s}}}\)
Authors: Alsaluli Amal , Fakieh Wafaa , Alashwali Hanaa
Published: December 2024

In this paper, we examine the interplay between the structural and spectral properties of the unit graph G(Zn) for n=p1r1p2r2…pkrk, where p1,p2,…,pk are distinct primes and k,r1,r2,…,rk are positive integers such that at least one of the ri must be greater than 1. We first analyze the structure of the unit graph of Zn, treating it as what we will define as a ‘generalized join graph’ under these conditions. We then determine the Laplacian spectrum of G(Zn) and deduce that it is integral for all n. Consequently, we obtain the Laplacian spectral radius and algebraic connectivity of G(Zn). We also prove that the vertex connectivity of G(Zpq) is (p−2)q, where 2≠p<q. We deduce the vertex connectivity of G(Zn) when n=prqs, where 2≠p<q are primes and r,s are positive integers. Finally, we present conjectures regarding the vertex connectivity of G(Zn) when n=p1p2…pk and n=p1r1p2r2…pkrk, where pi are distinct primes, ri are positive integers, and 1≤i≤k.
Geometric Nature of the Turánian of Modified Bessel Function of the First Kind
Authors: Sarkar Samanway , Prodanov Dimiter , Kumar Anish , Das Sourav
Published: December 2024

This work explores the geometric properties of the Turanian of the modified Bessel function of the first kind (TMBF). Using the properties of the digamma function, we establish conditions under which the normalized TMBF satisfies starlikeness, convexity, k-starlikeness, k-uniform convexity, pre-starlikeness, lemniscate starlikeness, and convexity, and under which exponential starlikeness and convexity are obtained. By combining methods from complex analysis, inequalities, and functional analysis, the article advances the theory of Bessel functions and hypergeometric functions. The established results could be useful in approximation theory and bounding the behavior of functions.
EIF-SlideWindow: Enhancing Simultaneous Localization and Mapping Efficiency and Accuracy with a Fixed-Size Dynamic Information Matrix
Authors: Léon Javier Lamar , Salgueiro Pedro , Gonçalves Teresa , Rato Luis
Published: December 2024

This paper introduces EIF-SlideWindow, a novel enhancement of the Extended Information Filter (EIF) algorithm for Simultaneous Localization and Mapping (SLAM). Traditional EIF-SLAM, while effective in many scenarios, struggles with inaccuracies in highly non-linear systems or environments characterized by significant non-Gaussian noise. Moreover, the computational complexity of EIF/EKF-SLAM scales with the size of the environment, often resulting in performance bottlenecks. Our proposed EIF-SlideWindow approach addresses these limitations by maintaining a fixed-size information matrix and vector, ensuring constant-time processing per robot step, regardless of trajectory length. This is achieved through a sliding window mechanism centered on the robot’s pose, where older landmarks are systematically replaced by newer ones. We assess the effectiveness of EIF-SlideWindow using simulated data and demonstrate that it outperforms standard EIF/EKF-SLAM in both accuracy and efficiency. Additionally, our implementation leverages PyTorch for matrix operations, enabling efficient execution on both CPU and GPU. Additionally, the code for this approach is made available for further exploration and development.
Isolation and Characterization of Bacillus Strains from Egyptian Mangroves: Exploring Their Endophytic Potential in Maize for Biological Control of Spodoptera frugiperda
Authors: Fathy Hayam M. , Awad Mona , Alfuhaid Nawal A. , Ibrahim El-Desoky S. , Moustafa Moataz A. M. , El-Zayat Ayatollah S.
Published: December 2024

The widespread use of pesticides to manage Spodoptera frugiperda has led to significant challenges. This insect has developed resistance to 47 active insecticide ingredients. Therefore, endophytic entomopathogenic bacteria have been explored as an alternative pest management strategy, offering the potential to reduce reliance on chemical pesticides. The current study aims to evaluate the colonization potential of indigenous marine Bacillus strains as endophytes in maize plants and to assess their insecticidal activity against S. frugiperda. Four inoculation methods—foliar application, seed treatment, soil drenching, and a combination of all three—were used to establish the Bacillus strains as endophytes in maize plants. Our results showed that the promising native Bacillus strains exhibited both antibacterial and insecticidal effects against S. frugiperda neonates under laboratory conditions. Foliar application of Bacillus sp. Esh39 caused the highest mortality rate (65%), followed by Bacillus tequilensis R39 (60%). However, this method did not significantly enhance plant height or chlorophyll content. The potential of these native Bacillus strains warrants further investigation to improve biological control via endophytic mediation. Our findings provide valuable insights into the bacterial diversity and functionality of mangrove ecosystems and pave the way for innovative, sustainable insect management strategies.
Role of the Unique Secreted Peptide Adropin in Various Physiological and Disease States
Authors: Hasanpour-Segherlou Zahra , Butler Andrew A. , Candelario-Jalil Eduardo , Hoh Brian L.
Published: December 2024

Adropin, a secreted peptide hormone identified in 2008, plays a significant role in regulating energy homeostasis, glucose metabolism, and lipid metabolism. Its expression is linked to dietary macronutrient intake and is influenced by metabolic syndrome, obesity, diabetes, and cardiovascular diseases. Emerging evidence suggests that adropin might be a biomarker for various conditions, including metabolic syndrome, coronary artery disease, and hypertensive disorders complicating pregnancy. In cerebrovascular diseases, adropin demonstrates protective effects by reducing blood–brain barrier permeability, brain edema, and infarct size while improving cognitive and sensorimotor functions in ischemic stroke models. The protective effects of adropin extend to preventing endothelial damage, promoting angiogenesis, and mitigating inflammation, making it a promising therapeutic target for cardiovascular and neurodegenerative diseases. This review provides a comprehensive overview of adropin’s multifaceted roles in physiological and pathological conditions, as well as our recent work demonstrating adropin’s role in subarachnoid hemorrhage-mediated neural injury and delayed cerebral infarction.
Mitophagy in Doxorubicin-Induced Cardiotoxicity: Insights into Molecular Biology and Novel Therapeutic Strategies
Authors: Zhang Heng , Xie Saiyang , Deng Wei
Published: December 2024

Doxorubicin is a chemotherapeutic drug utilized for solid tumors and hematologic malignancies, but its clinical application is hampered by life-threatening cardiotoxicity, including cardiac dilation and heart failure. Mitophagy, a cargo-specific form of autophagy, is specifically used to eliminate damaged mitochondria in autophagosomes through hydrolytic degradation following fusion with lysosomes. Recent advances have unveiled a major role for defective mitophagy in the etiology of DOX-induced cardiotoxicity. Moreover, specific interventions targeting this mechanism to preserve mitochondrial function have emerged as potential therapeutic strategies to attenuate DOX-induced cardiotoxicity. However, clinical translation is challenging because of the unclear mechanisms of action and the potential for pharmacological adverse effects. This review aims to offer fresh perspectives on the role of mitophagy in the development of DOX-induced cardiotoxicity and investigate potential therapeutic strategies that focus on this mechanism to improve clinical management.
Diagnostic Potential of Cytokine Biomarkers in Endometriosis: Challenges and Insights
Authors: Krygere Laura , Jukna Povilas , Jariene Kristina , Drejeriene Egle
Published: December 2024

Endometriosis is a common gynecological condition affecting approximately 10% of women of reproductive age, characterized by the abnormal presence of endometrial-like tissue outside the uterus. Although endometriosis was first described over 300 years ago, its underlying mechanisms remain poorly understood, and accurate, prompt diagnosis continues to be challenging. Currently, there is a lack of effective, non-invasive diagnostic methods, and available treatments often come with significant side effects and high recurrence rates. This has spurred interest in investigating the role of pro- and anti-inflammatory molecules, particularly cytokines, in endometriosis, as these molecules play a key role in its progression by influencing cell growth and differentiation. Previous studies suggest that various cytokines could serve as potential biomarkers for diagnosing endometriosis, as they are detectable in both serum and peritoneal fluid. This review provides an overview of the expression, origin, function, and regulation of specific cytokines in endometriosis, along with a brief discussion on their potential clinical implications for diagnosis. Due to the complexity of endometriosis, a panel of multiple biomarkers may ultimately be necessary for accurate diagnosis. It is essential to consider factors such as patient selection, sample collection, and analytical variability when initiating or evaluating biomarker studies.
Development of Preliminary Criteria of Macrophage Activation Syndrome in Multisystem Inflammatory Syndrome Associated with COVID-19 in Children
Authors: Avrusin Ilia S. , Bregel Liudmila V. , Efremova Olesya S. , Kostik Mikhail M.
Published: December 2024

Background: Macrophage activation syndrome (MAS) can be regarded as a key factor determining the severity of multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C), and often requires treatment in the intensive care unit (ICU) to avoid life-threatening complications. No reputable specific criteria for the diagnosis of MAS in MIS-C patients have yet been identified, and criteria currently used for the diagnosis of hemophagocytic syndromes, such as HLH-2004, MAS-2005, and MAS-2016, are not sufficient for MAS in MIS-C. Our goal in this study was to work out the criteria for the early diagnosis of MAS in MIS-C. Methods: One hundred and sixty-six (166) patients with MIS-C were assessed retrospectively. The two most experienced experts independently identified patients with MAS. The patients were divided into three cohorts: MAS (n = 19), without MAS (n = 78), and probable MAS (n = 67). The latter included patients diagnosed with MAS by only one expert, and it was excluded from the analysis. Results: The age of patients with MAS was much higher, and they more frequently had edematous syndrome, hypotension and/or shock, splenomegaly, and CNS involvement. In their blood tests, thrombocytopenia, hypoalbuminemia, and hypertriglyceridemia occurred more often. The level of biomarkers of inflammation, such as ferritin, CRP, troponin, AST, and ALT, was also higher in this group. Increased fibrinogen and D-dimer were also found, demonstrating hypercoagulation in the MAS-MIS-C group. We chose 21 continuous and categorical variables with statistical significance, out of which 2—ferritin > 469 μg/L or platelets < 114 × 109/L—allowed us to discriminate MAS patients. Conclusions: Ferritin > 469 μg/L or platelets < 114 × 109/L can be regarded as key signs to differentiate MAS in MIS-C patients with a sensitivity of 100% and specificity of 94.9%, and they can be used along with other diagnostic methods.
An Improved Spider Wasp Optimizer for UAV Three-Dimensional Path Planning
Authors: Liang Haijun , Hu Wenhai , Wang Lifei , Gong Ke , Qian Yuxi , Li Longchao
Published: December 2024

This paper proposes an Improved Spider Wasp Optimizer (ISWO) to address inaccuracies in calculating the population (N) during iterations of the SWO algorithm. By innovating the population iteration formula and integrating the advantages of Differential Evolution and the Crayfish Optimization Algorithm, along with introducing an opposition-based learning strategy, ISWO accelerates convergence. The adaptive parameters trade-off probability (TR) and crossover probability (Cr) are dynamically updated to balance the exploration and exploitation phases. In each generation, ISWO optimizes individual positions using Lévy flights, DE’s mutation, and crossover operations, and COA’s adaptive update mechanisms. The OBL strategy is applied every 10 generations to enhance population diversity. As the iterations progress, the population size gradually decreases, ultimately yielding the optimal solution and recording the convergence process. The algorithm’s performance is tested using the 2017 test set, modeling a mountainous environment with a Gaussian function model. Under constraint conditions, the objective function is updated to establish a mathematical model for UAV flight. The minimal cost for obstacle-avoiding flight within the specified airspace is obtained using the fitness function, and the flight path is smoothed through cubic spline interpolation. Overall, ISWO generates high-quality, smooth paths with fewer iterations, overcoming premature convergence and the insufficient local search capabilities of traditional genetic algorithms, adapting to complex terrains, and providing an efficient and reliable solution.
A Whole-Body Coordinated Motion Control Method for Highly Redundant Degrees of Freedom Mobile Humanoid Robots
Authors: Niu Hao , Zhao Xin , Jin Hongzhe , Zhang Xiuli
Published: December 2024

Humanoid robots are becoming a global research focus. Due to the limitations of bipedal walking technology, mobile humanoid robots equipped with a wheeled chassis and dual arms have emerged as the most suitable configuration for performing complex tasks in factory or home environments. To address the high redundancy issue arising from the wheeled chassis and dual-arm design of mobile humanoid robots, this study proposes a whole-body coordinated motion control algorithm based on arm potential energy optimization. By constructing a gravity potential energy model for the arms and a virtual torsional spring elastic potential energy model with the shoulder-wrist line as the rotation axis, we establish an optimization index function for the arms. A neural network with variable stiffness is introduced to fit the virtual torsional spring, representing the stiffness variation trend of the human arm. Additionally, a posture mapping method is employed to map the human arm potential energy model to the robot, enabling realistic humanoid movements. Combining task-space and joint-space planning algorithms, we designed experiments for single-arm manipulation, independent object retrieval, and dual-arm carrying in a simulation of a 23-degree-of-freedom mobile humanoid robot. The results validate the effectiveness of this approach, demonstrating smooth motion, the ability to maintain a low potential energy state, and conformity to the operational characteristics of the human arm.
Electroencephalography (EEG) for Neurological Prognostication in Post-Anoxic Coma Following Cardiac Arrest and Its Relationship to Outcome
Authors: Shivji Zaitoon , Bendahan Nathaniel , McInnis Carter , Woodford Timothy , Einspenner Michael , Calder Lisa , Boissé Lomax Lysa , Shukla Garima , Winston Gavin P.
Published: December 2024

Background/Objectives: Cardiac arrest may cause significant hypoxic–ischemic injury leading to coma, seizures, myoclonic jerks, or status epilepticus. Mortality is high, but accurate prognostication is challenging. A multimodal approach is employed, in which electroencephalography (EEG) forms a key part with several recognised patterns of prognostic significance. Methods: In this retrospective study, clinical and qualitative features of the EEG of patients admitted to the Intensive Care Unit (ICU) at Kingston General Hospital following cardiac arrest from 2017 to 2020 were reviewed. The study included 81 adult patients (≥18 years). Outcome was assessed using the Cerebral Performance Category (CPC) as 1–2 (favourable) or 3–5 (unfavourable). EEG patterns were divided into groups within the highly malignant, malignant and benign patterns described in the literature. Results: There were a wide range of causes and 22% had a favourable outcome. Highly malignant, malignant and benign patterns were associated with survival in 0%, 70% and 100%, respectively, and favourable outcomes in 0%, 48% and 100%. All patients with seizures died, and 94% with myoclonus had unfavourable outcomes. In contrast, EEG reactivity and improvement on follow-up EEG were associated with a favourable outcome. Conclusions: Highly malignant EEG, seizures and myoclonus were associated with unfavourable outcomes, while patients with malignant EEG had better outcomes.
Standardizing Domains and Metrics of Stroke Recovery: A Systematic Review
Authors: Akkara Yash , Afreen Ryan , Lemonick Michael , Paz Santiago Gomez , Rifi Ziad , Tosto Jenna , Putrino David , Mocco J. , Bederson Joshua , Dangayach Neha , Kellner Christopher P.
Published: December 2024

Background and Aims: Measuring stroke recovery poses a significant challenge, given the complexity of the recovery process. We aimed to identify a standardized and data-driven set of metrics of stroke rehabilitation in the literature that ensures the inclusion of all recovery domains and subdomains in the literature. Methods: A systematic review was conducted by four reviewers using the PRISMA guidelines on PubMed, MEDLINE, and Embase for stroke recovery articles between 2004 and 2024. The inclusion criteria comprised experimental/observational studies, including ischemic and hemorrhagic stroke. All studies had ≥20 participants who were ≥18 years of age, and had a follow-up of ≥3 months. Outcomes included demographics, geographic origin, stroke mechanism, domains and subdomains, metrics used, and follow-up. A bias assessment was performed using the Newcastle-Ottawa Scale and the Cochrane Risk of Bias 2.0 tool. This study was registered with PROSPERO (CRD42024551753). Results: Our search included 324 studies with a sample of 85,156 participants. The study identified seven domains (perception, physical and motor function (PF), speech and language (S&L), cognition, activities of daily living (ADL), quality of life (QoL), and social interaction) and 96 constituent subdomains that encompass the complete landscape of the stroke recovery literature identified. The domains of PF and ADL constituted the vast share of the literature, albeit reducing in their relative representation over time, while domains such as perception and QoL have been increasingly studied since 2004. Using the domains, the study identified the set and frequency of all commonly used metrics to measure stroke recovery in the literature, of which the NIHSS (n = 72), BI (n = 55), and mRS (n = 51) were the most commonly used. We identified eighteen standard metrics that ensure the inclusion of all seven domains and 96 subdomains. Summary of Review and Conclusions: The identified set of domains and metrics within this study can help inform further clinical research and decision-making by providing a standardized set of metrics to be used for each domain. This approach ensures lesser represented domains and subdomains are also included during testing, providing a more complete view and measure of stroke recovery.
Demographic Differences and Associations Between Body Image and Quality of Life Among Japanese Adolescents with Congenital Physical Disabilities
Authors: Kim Minkyeong , Kawama Kennosuke , Lim Yongjae
Published: December 2024

This study aimed to examine the levels, demographic differences, and associations between body image (BI) and quality of life (QOL) among Japanese adolescents with congenital physical disabilities. A self-report questionnaire was administered to 107 Japanese adolescents with congenital physical disabilities, which included demographic variables, the Multidimensional Body-Self Relations Questionnaire, and the Japanese version of the World Health Organization Quality of Life Brief Version. Data were analyzed using Cronbach’s α coefficient, descriptive statistics, t-tests, one-way ANOVA, and Pearson’s correlation coefficient. The mean BI score was 2.96 ± 0.39. The domain-specific mean scores were as follows: health evaluation (3.49 ± 0.67), health orientation (3.11 ± 0.57), fitness evaluation (3.03 ± 0.93), fitness orientation (3.02 ± 0.70), appearance orientation (2.70 ± 0.61), and appearance evaluation (2.61 ± 0.61). The mean QOL score was 3.51 ± 0.50. The domain-specific mean scores were as follows: social relationships (3.61 ± 0.91), environment (3.60 ± 0.59), physical (3.46 ± 0.55), and psychological (3.42 ± 0.63). BI significantly varied by gender, school level, type of disability, and activities of daily living (ADLs), while QOL varied by school level and ADLs. All BI domains, except appearance orientation (investments for enhancing appearance), were positively correlated with QOL. Our findings suggest that school level and ADLs are key predictors of both BI and QOL among Japanese adolescents with congenital physical disabilities and that physical-fitness- and health-related BI are closely associated with QOL.
Technology for Treatment and Reinforcement of Soft Rock Tunnel Floor Using Sealing Material
Authors: Liu Yongli , Tao Lei , Zhao Shenglei , Chen Weixin , Ni Yaozu
Published: December 2024

To maintain the stability of soft rock tunnels, the research team proposed a support scheme involving “floor grouting + floor anchors + sealing material”. This scheme incorporates a new sealing material with excellent mechanical properties, airtightness, and cost-effectiveness. To develop the sealing material, a series of proportioning tests and optimization designs were conducted to investigate how various experimental factors influence material performance. Based on these experiments, a regression prediction model was established to reveal the characteristics of factor interactions and determine the optimal mix ratio. Practical engineering validation confirmed that this support scheme effectively controls floor heave in soft rock tunnels.
Adapting Management Control Systems to Organizational Contingency Factors: A Study of Moroccan Industrial Companies
Authors: Hammouch Hind , Manta Otilia , Palazzo Maria
Published: December 2024

This study investigates how organizational contingency factors, namely company size, environmental uncertainty, technological capacity, and organizational structure, affect the design and effectiveness of management control systems (MCS) in Moroccan industrial companies. Drawing on contingency theory, which emphasizes the alignment of organizational systems with contextual factors, this research applies quantitative methods to a sample of 190 industrial firms in Morocco, achieving a 76% response rate to the distributed surveys. The data are analyzed using correlation and linear regression techniques to explore these relationships. The findings reveal that larger firms, those operating in dynamic and uncertain environments, and those with advanced technological systems tend to implement more sophisticated, integrated, and participative MCS. Furthermore, flexible and decentralized organizational structures significantly enhance the adoption of adaptive control systems. These results underscore the importance of tailoring MCS to organizational characteristics and environmental conditions, particularly in emerging market contexts. This study’s novel contribution lies in its application of contingency theory to a non-Western industrial context, addressing a gap in the literature by demonstrating how specific regional factors influence MCS practices. This research offers practical insights for Moroccan industrial firms seeking to improve their operational efficiency, adaptability, and strategic decision making in volatile markets.
Impact of Vitamin D Levels on Progression-Free Survival and Response to Neoadjuvant Chemotherapy in Breast Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Ottaiano Alessandro , Facchini Bianca Arianna , Iacovino Marialucia , Santorsola Mariachiara , Facchini Sergio , Di Mauro Giordana , Toscano Enrica , Montopoli Monica , Di Mauro Annabella , Quagliariello Vincenzo , Maurea Nicola , Vanni Gianluca , Bignucolo Alessia , Montella Liliana , Materazzo Marco , Roselli Mario , Buonomo Oreste Claudio , Berretta Massimiliano
Published: December 2024

Background: Breast cancer remains the leading cause of cancer-related deaths among women despite advances in early detection. Neoadjuvant chemotherapy (NACT) is now standard for early-stage BC, with vitamin D (VD) emerging as a potential prognostic biomarker considering its positive pleiotropic effects. This review and meta-analysis assess the impact of baseline VD levels on outcomes in BC patients undergoing NACT. Methods: Inclusion criteria required patients to be over 18 years of age, have a pathologically confirmed BC diagnosis, and have their VD levels assessed prior to chemotherapy. Studies were included if they reported odds ratios (ORs) for response and/or hazard ratios (HRs) for PFS with 95% confidence intervals (CIs). A comprehensive literature search of PubMed/MEDLINE and Scopus/ELSEVIER (2014–2024) was conducted, and data were analyzed using fixed- and random-effects models, with Forest plots illustrating the results. Study quality and potential biases were assessed using the MINORS, NOS, and RoB2 scales, and statistical heterogeneity was evaluated with I2 statistics and funnel plots. Results: Six studies were included in the analysis. All studies addressed stages II and III, with three also including stage I. The meta-analysis covered data from 722 patients regarding NACT response and 1033 patients for PFS. The results revealed a 22% reduction in the likelihood of non-response to NACT associated with adequate VD levels (low/deficient VD vs. high/sufficient VD; OR: 0.78; 95% CI: 0.30–1.25; p = 0.001) and a 35% reduction in progression risk with sufficient baseline VD levels (low/deficient VD vs. high/sufficient VD; HR: 0.65; 95% CI: 0.33–0.97; p < 0.001). Conclusions: These findings highlight the significance of maintaining adequate vitamin D levels in BC treatment and encourage further studies to unravel the role of VD on cancer biology.
Insights into the Role of Pt Promoter in Co/TiO2 Catalysts for CO Hydrogenation
Authors: Hu Changsong , Qiu Chengwu , Zhang Wenli , Song Jinliang , Meng Qingwei , Yuan Qingchun , Wang Tiejun
Published: December 2024

Platinum is widely used as a reduction promoter in transition metal heterogeneous catalysts, while its effects on the catalyst’s properties and CO hydrogenation behavior remain unclear. In this study, an improvement in the reducibility of platinum-promoted catalysts is observed. Notably, platinum suppresses the aggregation of cobalt nanoparticles (CoNPs) during catalyst preparation, as evidenced by STEM/TEM and XRD analyses, which reveal the presence of smaller CoNPs and weakened cobalt diffraction in platinum-promoted catalysts. In addition, platinum also promotes the formation of more active hexagonal close-packed (hcp) cobalt but inhibits metal-support interaction (MSI). Therefore, the cobalt-time yield (CTY) for CO hydrogenation in the promoted catalyst is strongly improved, and, furthermore, its intrinsic activity (turnover frequency, TOF) is also slightly increased. However, the product distribution seems unchanged except for the CO2 for the platinum-promoted catalysts.
Generating Disk-Shaped MTW Zeolite with Reduced Channel Length Using Polycation Structure-Directing Agent for Hydroisomerization of N-Dodecane
Authors: Qie Guanyu , Zhai Miao , Zhu Kake , Zhu Xuedong
Published: December 2024

The development of hierarchically structured zeolites to mitigate diffusion limitations and improve catalytic performance constitutes a focus of current research. In this study, we present the synthesis of hierarchical disk-shaped MTW zeolite (ZSM-12-P) with shortened channel length using polycation [-C5H9N+C10H10N+C5H9-C3H6-]n[Br−]2n (PDIP) as an organic structure-directing agent (OSDA). The ZSM-12-P zeolite forms disk-shaped structures with thicknesses ranging from 140 to 160 nm and exhibits rotational intergrowth. These structures are composed of interconnected nanocrystalline domains that form mesopores accessible from the outer surface, while the microporous channels extend along the thickness direction. In addition, the polycationic OSDA possesses strong interaction with framework and MTW structure-directing ability, enabling the successful synthesis of the Al-rich ZSM-12-P. Owing to its strong acidity and improved diffusion property, the Pt/HZSM-12-P catalyst demonstrates enhanced catalytic n-dodecane hydroisomerization activity and isomer yield.
Knoevenagel Condensation Catalyzed by Biogenic Carbonates for the Solvent-Free Synthesis of 3-(Furan-2-yl)acrylonitrile Derivatives
Authors: Mesa Castro Eliana Yasmín , Monroy Ramírez Andrés Felipe , Martínez José Jobanny , Castillo Juan-Carlos , Caicedo Pineda Gerardo Andrés
Published: December 2024

Calcium and barium carbonates were synthesized via biologically induced mineralization using Bacillus subtilis. The biogenic materials were characterized by using infrared and Raman spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and powder X-ray diffraction. These biogenic carbonates were then tested as basic heterogenous catalysts for the solvent-free Knoevenagel reaction between 5-HMF derivatives and active methylene compounds, producing 3-(furan-2-yl)acrylonitrile derivatives in 71–87% yields. Optimal catalytic performance was achieved with a 50:50 Ca:Ba ratio, attributed to the synergistic interaction between baritocalcite and vaterite, which enhances the availability of active basic sites and surface interactions. This method offers operational simplicity, reduced reaction times, good yields, excellent (E)-selectivity, and minimal catalyst loading.
Exploring the Role of Axons in ALS from Multiple Perspectives
Authors: Chen Xiaosu , Lv Shuchang , Liu Jinmeng , Guan Yingjun , Xu Chunjie , Ma Xiaonan , Li Mu , Bai Xue , Liu Kexin , Zhang Haoyun , Yan Qiupeng , Zhou Fenghua , Chen Yanchun
Published: December 2024

Amyotrophic lateral sclerosis (ALS), commonly known as motor neuron disease, is a neurodegenerative disorder characterized by the progressive degeneration of both upper and lower motor neurons. This pathological process results in muscle weakness and can culminate in paralysis. To date, the precise etiology of ALS remains unclear. However, a burgeoning body of research indicates that axonal dysfunction is a pivotal element in the pathogenesis of ALS and significantly influences the progression of disease. Dysfunction of axons in ALS can result in impediments to nerve impulse transmission, leading to motor impairment, muscle atrophy, and other associated complications that severely compromise patients’ quality of life and survival prognosis. In this review, we concentrate on several key areas: the ultrastructure of axons, the mechanisms of axonal degeneration in ALS, the impact of impaired axonal transport on disease progression in ALS, and the potential for axonal regeneration within the central nervous system (CNS). Our objective is to achieve a more holistic and profound understanding of the multifaceted role that axons play in ALS, thereby offering a more intricate and refined perspective on targeted axonal therapeutic interventions.
Myosin Light Chains in the Progression of Cancer
Authors: Kozole Savannah L. , Beningo Karen A.
Published: December 2024

The myosin light chains (MLCs) of non-muscle myosin II are known to regulate cellular architecture and generate cellular forces; they also have an increasingly emerging role in the progression of cancer. The phosphorylation state of the myosin light chains controls the activity of myosins that are implicated in invasion and proliferation. In cancers, when proliferation is greatly increased, cytokinesis relies on phosphorylated light chains to activate the contractile forces used to separate the cells. Likewise, during metastasis, kinase pathways culminate in aligning MLC structures for enhanced cell motility through stress fiber contraction and the accumulation of myosin filaments at the leading edge. This review summarizes the myosin light chain family members known to promote cancer progression and evidence of how their altered activities change the behavior of cells involving the mechanical-based processes of proliferation and cell movements during metastasis. In addition, myosin light chains impact the immune response to cancers and currently serve as biomarkers in staging this disease; a brief summary of these topics is provided at the end of the review.
Cellular Immunology of Myocarditis: Lights and Shades—A Literature Review
Authors: Vicenzetto Cristina , Giordani Andrea Silvio , Menghi Caterina , Baritussio Anna , Scognamiglio Federico , Pontara Elena , Bison Elisa , Peloso-Cattini Maria Grazia , Marcolongo Renzo , Caforio Alida Linda Patrizia
Published: December 2024

Myocarditis is an inflammatory disease of the myocardium with heterogeneous etiology, clinical presentation, and prognosis; when it is associated with myocardial dysfunction, this identifies the entity of inflammatory cardiomyopathy. In the last few decades, the relevance of the immune system in myocarditis onset and progression has become evident, thus having crucial clinical relevance in terms of treatment and prognostic stratification. In fact, the advances in cardiac immunology have led to a better characterization of the cellular subtypes involved in the pathogenesis of inflammatory cardiomyopathy, whether the etiology is infectious or autoimmune/immune-mediated. The difference in the clinical course between spontaneous recovery to acute, subacute, or chronic progression to end-stage heart failure may be explained not only by classical prognostic markers but also through immune-pathological mechanisms at a cellular level. Nevertheless, much still needs to be clarified in terms of immune characterization and molecular mechanisms especially in biopsy-proven myocarditis. The aims of this review are to (1) describe inflammatory cardiomyopathy etiology, especially immune-mediated/autoimmune forms, (2) analyze recent findings on the role of different immune cells subtypes in myocarditis, (3) illustrate the potential clinical relevance of such findings, and (4) highlight the need of further studies in pivotal areas of myocarditis cellular immunology.
Discovery of Carbonic Anhydrase 9 as a Novel CLEC2 Ligand in a Cellular Interactome Screen
Authors: Hoffmann Sebastian , Berger Benedict-Tilman , Lucas Liane Rosalie , Schiele Felix , Park John Edward
Published: December 2024

Membrane proteins, especially extracellular domains, are key therapeutic targets due to their role in cell communication and associations. Yet, their functions and interactions often remain unclear. This study presents a general method to discover interactions of membrane proteins with immune cells and subsequently to deorphanize their respective receptors. We developed a comprehensive recombinant protein library of extracellular domains of human transmembrane proteins and proteins found in the ER-Golgi-lysosomal systems. Using this library, we conducted a flow-cytometric screen that identified several cell surface binding events, including an interaction between carbonic anhydrase 9 (CAH9/CA9/CAIX) and CD14high cells. Further analysis revealed this interaction was indirect and mediated via platelets bound to the monocytes. CA9, best known for its diverse roles in cancer, is a promising therapeutic target. We utilized our library to develop an AlphaLISA high-throughput screening assay, identifying CLEC2 as one robust CA9 binding partner. A five-amino-acid sequence (EDLPT) in CA9, identical to a CLEC2 binding domain in Podoplanin (PDPN), was found to be essential for this interaction. Like PDPN, CA9-induced CLEC2 signaling is mediated via Syk. A Hodgkin’s lymphoma cell line (HDLM-2) endogenously expressing CA9 can activate Syk-dependent CLEC2 signaling, providing enticing evidence for a novel function of CA9 in hematological cancers. In conclusion, we identified numerous interactions with monocytes and platelets and validated one, CA9, as an endogenous CLEC2 ligand. We provide a new list of other putative CA9 interaction partners and uncovered CA9-induced CLEC2 activation, providing new insights for CA9-based therapeutic strategies.
Co-Inhibition of tGLI1 and GP130 Using FDA-Approved Ketoconazole and Bazedoxifene Is Synergistic Against the Growth and Metastasis of HER2-Enriched and Triple-Negative Breast Cancers
Authors: Manore Sara , Zhuang Chuling , Najjar Mariana K. , Wong Grace L. , Bindal Shivani , Watabe Kounosuke , Lin Jiayuh , Lo Hui-Wen
Published: December 2024

Breast cancer stem cells (CSCs) are resistant to most cancer therapeutics and contribute to tumor recurrence and metastasis. Two breast CSC-promoting transcription factors, truncated glioma-associated oncogene homolog 1 (tGLI1) and signal transducer and activator of transcription 3 (STAT3), have been reported to be frequently co-expressed in HER2-enriched breast cancer and triple-negative breast cancer (TNBC), undergo protein-protein interactions for gene regulation and activation, and functionally cooperate to promote breast CSCs. STAT3 can be activated by activated interleukin-6 receptor/glycoprotein-130 (IL-6R/GP130). Co-targeting of tGLI1 and IL-6R/GP130 has not been investigated in breast cancer or any tumor type. Here, we report that tGLI1 and GP130 are co-overexpressed in the majority of HER2-enriched breast cancers and TNBCs at 53.8% and 44.4%, respectively. tGLI1+IL-6/IL-6R/GP130 signaling is frequently co-enriched and co-activated in HER2-enriched breast cancer and TNBC when compared to luminal subtypes. tGLI1+GP130 co-overexpression strongly promotes CSCs of HER2-enriched breast cancer and TNBC. FDA-approved tGLI1 inhibitor Ketoconazole and GP130 inhibitor Bazedoxifene synergize against breast cancer proliferation and CSC phenotypes in vitro and reduce TNBC tumor growth and metastatic burden in vivo. Our study demonstrates, for the first time, that co-targeting tGLI1 and IL-6R/GP130/STAT3 signaling pathways is synergistic against HER2-enriched breast cancer and TNBC, warranting future clinical investigations.
Osseoconductive CaTi4-zZrz(PO4)6 Ceramics: Solutions Towards Nonunion, Osteoporosis, and Osteoarthrosis Conditions?
Authors: Heimann Robert B.
Published: December 2024

Transition (Ti, Zr) metal-substituted calcium hexaorthophosphate CaTi4-zZrz(PO4)6 coatings with an NaSICon structure were deposited by atmospheric plasma spraying (APS) onto Ti6Al4Veli substrates using a statistical design of experiments (SDE) methodology. Several coating properties were determined, including chemical composition, porosity, surface roughness, tensile adhesion strength, shear strength, and solubility in protein-free simulated body fluid (pf-SBF) and TRIS-HCl buffer solution. The biological performance evaluation involved cell proliferation and vitality studies and osseointegration tests of coated Ti6Al4Veli rods intramedullary implanted in sheep femora. After a 6 months observation time, a satisfactory gap-bridging potential was apparent as shown by a continuous, well-adhering layer of newly formed cortical bone. These tests suggest that the coatings possess a suitable osseoconductive potential and present an enhanced expression of bone growth-supporting non-collagenous proteins and cytokines, a high cell proliferation, spreading and vitality, and substantial osseointegration by strong bone apposition. The moderate intrinsic ionic conductivity of CaTi4-zZrz(PO4)6 compounds can be augmented by doping with highly mobile Na+ or Li+ ions to levels that suggest their use in electric bone growth stimulation (EBGS) devices, able to treat nonunion (pseudoarthrosis) and osteoporosis, and that may also support spinal stabilisation by vertebral fusion.
A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study
Authors: Salamanova Evdokiya , Atanasova Mariyana , Doytchinova Irini
Published: December 2024

Cholinesterases are enzymes that break down the neurotransmitter acetylcholine in the nervous system. The two main types are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). AChE inhibitors are used to treat Alzheimer’s disease by increasing acetylcholine levels. BChE activity increases in later stages of Alzheimer’s, suggesting it might contribute to the disease. In previous experiments, it was found that a newly designed hybrid of galantamine (GAL) and curcumin (CCN) (compound 4b) decreases the activity of BChE in murine brain homogenates. Here, we explore this observation using molecular dynamics simulations. GAL and CCN were also studied for comparison. The structures of the complexes between the BChE and the ligands were predicted by molecular docking. Then, molecular dynamics simulations were performed to evaluate the stability of the complexes and the interactions between the ligands and the enzyme over a simulated time of 1 μs. All three ligands formed stable complexes with BChE. Compound 4b formed more hydrogen bonds and other interactions with BChE compared to GAL and CCN, suggesting a stronger binding affinity. The stronger binding of 4b to BChE might explain its superior anti-BChE activity observed in previous experiments.