bluuebunny/crossref_metadata_2025 huggingface dataset:
Perfil de biomarcadores inflamatórios dos pacientes com pneumonia de um hospital no alto sertão paraibano / Profile of inflammatory biomarkers of patients with pneumonia in a hospital in the upper sertão of Paraíba
Authors: Nóbrega de Souza Kamilla Zenóbya Ferreira , De Assis Elisangela Vilar , Bacci Marcelo Rodrigues
Published: November 2021

Objetivo: Avaliar alterações no perfil de biomarcadores (proteína C reativa, fator de necrose tumoral, interleucina 6 e creatinina) em pacientes com pneumonia, durante o período de internação segundo a sobrevivência ou óbito, relacionando a gravidade do quadro de pneumonia ou indicativo de desenvolvimento de doença renal aguda em pacientes com pneumonia. Método: Foi realizado um estudo prospectivo com 47 pacientes que foram internados com pneumonia, no município de Cajazeiras, PB. Foram realizadas análises laboratoriais para quantificação sérica de creatinina, proteína C reativa, IL-6 e TNF- α. Resultados: Foram analisados segundo o teste de Mann-Whitney e o teste de correlação de Spearman. Foram consideradas diferenças significativas quando p0,05. Observou-se que os níveis de creatinina, proteína C reativa, IL-6 e TNF-α estavam mais elevados no grupo dos pacientes com pneumonia que vieram a óbito.  Os pacientes com pneumonia e doença renal aguda, do grupo que foram a óbito apresentaram maiores níveis de creatinina e IL-6. Para esse o grupo, os níveis de creatinina, TNF-α e IL-6 apresentaram correlação diretamente proporcionais ao escore da escala de CURB-65. Conclusão: Sugere-se que biomarcadores inflamatórios podem ser utilizados no monitoramento de agravo no quadro clínico da doença.Palavras-chave: Creatinina. Fator de Necrose Tumoral Alfa. Interleucina-6. Pneumonia. Proteína C-reativa. Abstract: The aim of this study was to evaluate changes in the profile of biomarkers (C-reactive protein, tumor necrosis factor, interleukin 6 and creatinine) in patients with pneumonia, during the hospitalization period, according to survival or death, relating the severity of pneumonia or indicative of development of acute kidney disease in patients with pneumonia. A prospective study was carried out with 47 patients who were hospitalized with pneumonia in the city of Cajazeiras, Paraíba. Laboratory analyzes were performed to quantify serum creatinine, C-reactive protein, IL-6 and TNF-α. Results were analyzed using the Mann-Whitney test and the Spearman correlation test. Significant differences were considered when p0.05. It was observed that the levels of creatinine, C-reactive protein, IL-6 and TNF-α were higher in the group of patients with pneumonia who died. Patients with pneumonia and acute kidney disease from the group who died had higher levels of creatinine and IL-6. For this group, creatinine, TNF-α and IL-6 levels correlated directly proportional to the CURB-65 scale score. It is suggested that inflammatory biomarkers can be used to monitor the disease's clinical condition. Keywords: Creatinine. Tumor Necrosis Factor Alpha. Interleukin-6. Pneumonia. C-reactive protein.
Práticas com o Profissional e Cuidador de Crianças Autistas / Practices with the Professional and Caregiver of Autistic Children
Authors: Rodrighero Karoline Tobo , Souza Carolina Tarcinalli
Published: November 2021

Resumo: A criança com Transtorno do Espectro Autístico (TEA) apresenta uma tríade caracterizada pela dificuldade e prejuízos qualitativos da comunicação verbal e não verbal, na interatividade social e na restrição do seu ciclo de atividades e interesses. O profissional tem uma grande importância na função de capacitar, instruir, supervisionar e orientar os cuidadores e familiares a realizar as atividades com as crianças com autismo. O objetivo deste  estudo  foi  ensinar  com  aulas  práticas  voltadas  para  o  desempenho  neuropsicomotor  a  interação  do profissional e cuidador com os autistas. O estudo foi composto por quatro etapas: (1) observação pré-intervenção; (2) elaboração dos materiais; (3) encontros para a implantação do treinamento; (4) interação do profissional e cuidador com os autistas. Após a interação proposta para os profissionais e cuidadores, foi possível observar o que pode ser modificado tanto no ambiente em que eles convivem com as crianças autistas quanto na prática do dia á dia.  Pode-se  concluir  que  a interação  de  uma  equipe  interdisciplinar,  colabora  para  o  maior  e  melhor desenvolvimento neuropsicomotor das crianças autistas, sendo estas como: motricidade fina, motricidade grossa, sensorial, coordenação, melhoria da deglutição, adaptação dessas crianças na sala de aula, melhoria quanto à marcha, equilíbrio, capacidade de concentração e comunicação.
Uma Análise da Sociedade Burguesa nas Sutilezas Machadianas do Conto “Uns Braços” / An Analysis of Bourgeois Society in Machadian Subtleties of the Tale “Uns Braços”
Authors: Florêncio Roberto Remígio , Rodrigues Juliana Albuquerque , Monteiro Renata Xavier , Santos Maria Celma Vieira
Published: November 2021

Resumo: Ao analisar o comportamento feminino das personagens de Machado de Assis, o ensino da Literatura no nível médio pode ganhar elementos para provocar a criticidade do aluno-leitor. Este texto focaliza o perfil da mulher submissa, recatada e reprimida pelos costumes e hábitos da sociedade brasileira do século XIX, baseados no machismo e na preservação da moralidade. A escolha do tema se deu pela necessidade de se trabalhar uma literatura reflexiva, que promova a criticidade e busque desenvolver o hábito da leitura no Ensino Médio. Apresentamos excertos do conto Uns Braços para ilustrar o desejo reprimido de uma senhora da sociedade, infeliz no casamento, em relação a um jovem rapaz, que a admira em silêncio. Assim, suscita uma reflexão acerca da mulher burguesa da época, que reverbera nas mulheres da atualidade. Os objetivos pretendidos foram alcançados, uma vez que se torna notória a possibilidade de análise reflexiva dos contos machadianos, com seus personagens e acontecimentos que trazem reflexões para a vida humana, seja na contextualização da época, seja na reflexão crítica da atualidade. Palavras-chave: Literatura Brasileira. Sociedade Burguesa. Formação de Leitores.Abstract: By analyzing the female behavior of Machado de Assis' characters, the teaching of Literature at secondary level can gain elements to provoke the criticality of the student-reader. This text focuses on the profile of the submissive woman, demure and repressed by the customs and habits of nineteenth century Brazilian society, based on machismo and the preservation of morality. The theme was chosen because of the need to work on a reflective literature that promotes criticality and seeks to develop the habit of reading in high school. We present excerpts from the short story: "Uns Braços" to illustrate the repressed desire of a society lady, unhappy in her marriage, for a young man, who admires her in silence. Thus, it raises a reflection on the bourgeois woman of the time, which reverberates in women today. The intended objectives were achieved, since the possibility of reflective analysis of Machado's tales becomes notorious, with their characters and events that bring reflections to human life, whether in the context of the time, or in the critical reflection of today. Keywords: Brazilian Literature. Bourgeois Society. Reader’s training.
Implantação de um Programa Multiprofissional de Assistência em Cuidado Paliativo: Relato de Experiência / Implementation of a Multiprofessional Assistance Program in Palliative Care: Experience Report
Authors: Toldo Ana Paula Ribeiro , Krause Hildegard Magdalena Klever , Robert Inez Maria de Fátima
Published: November 2021

Resumo: Cuidado paliativo é uma abordagem que ampara a assistência do profissional de saúde nos cuidados aos doentes em situação de intenso sofrimento, decorrente de doença que ameaça a continuidade da vida, tendo como objetivo promover alívio do sofrimento e qualidade de vida do paciente e familiares, dentro das medidas possíveis e até o fim da vida. O estudo teve por objetivo realizar e descrever a implantação e implementação de um programa multiprofissional de assistência em Cuidado Paliativo. O estudo caracterizado como uma pesquisa ação, apresenta 5 fases para o desenvolvimento da proposta do serviço. Com a implementação do programa, pode-se proporcionar a humanização da equipe multiprofissional no trato aos pacientes e familiares. Dentre as expectativas que se atribuíram à proposta de criação de um serviço de cuidado paliativo, sua criação e aplicação foram realizadas dentro do tempo esperado, além de um aproveitamento e resultados maior do que os previamente previstos.Palavras-Chave: Cuidado paliativo; doentAbstract: Palliative care is an approach that supports the assistance of health professionals in the care of patients in situations of intense suffering, resulting from a disease that threatens the continuity of life, aiming to promote relief of suffering and quality of life for patients and their families, within of possible measures and until the end of life. The study aimed to carry out and describe the implementation and implementation of a multiprofessional assistance program in Palliative Care. The study characterized as action research, presents 5 phases for the development of the service proposal. With the implementation of the program, the humanization of the multidisciplinary team in dealing with patients and families can be provided. Among the expectations that were attributed to the proposal to create a palliative care service, its creation and application were carried out within the expected time, in addition to a better use and results than those previously expected. Keywords: Palliative care; chronically ill; assistance.e crônico; assistência.
Recursos Humanos frente às exigências contemporâneas de mudanças no ambiente de trabalho / Human Resources in view of the contemporary demands of changes in the work environment
Authors: Martins Paola Rodrigues , Nunes Ana Lúcia De Paula Ferreira
Published: November 2021

Resumo: Este artigo busca entender a área administrativa dos Recursos Humanos (RH) e as exigências do uso de home office no ambiente do trabalho frente às mudanças resultantes da pandemia do Covid-19. O principal objetivo é analisar os benefícios e os desafios da adoção do home office sob a perspectiva de profissionais do departamento de Recursos Humanos mediante as mudanças que impulsionaram este trabalho nas empresas. O estudo partiu dos seguintes questionamentos: quais os principais impactos da pandemia do Covid-19 na gestão de Recursos Humanos? Como as empresas se adaptaram às mudanças impostas? A metodologia escolhida para responder essas questões foi uma pesquisa bibliográfica, foram identificadas realizada em dez publicações de maior relevância ao tema, através de artigos publicados no período de 2020 e 2021. A linha de pesquisa resultou na conclusão que durante a pandemia da Covid-19, uma das áreas que mais sofreu impacto foi a do trabalho, contudo, apesar das barreiras, o trabalho em home office foi absorvido nas empresas impulsionando a área de Recursos Humanos no sentido de modificar seus processos de gestão de pessoas. Palavras-chave: Empresas. Pandemia. Recursos humanos. Home office. Abstract: This article seeks to understand the administrative area of Human Resources (HR) and the requirements of the use of home office in the work environment in view of the changes resulting from the Covid-19 pandemic. The main objective is to analyze the benefits and challenges of adopting the home office from the perspective of professionals in the Human Resources department through the changes that drove this work in companies. The study was based on the following questions: what are the main impacts of the Covid-19 pandemic on Human Resources management? How have companies adapted to the imposed changes? The methodology chosen to answer these questions was a literature search, which were identified in ten publications of greater relevance to the topic, through articles published in the period 2020 and 2021. The line of research resulted in the conclusion that during the Covid-19 pandemic , one of the areas that suffered the most impact was work, however, despite the barriers, home office work was absorbed in the companies, boosting the Human Resources area in order to modify its people management processes. Keywords: Companies. Pandemic. Human Resources. Home office.
Leitura e Escrita: Desafios e Possibilidades no Ensino Fundamental - anos iniciais / Reading and Writing: Challenges and Possibilities in Elementary School - Early Years
Authors: Alencar Bruna Hiasmim Pires de Sá , França Aurenia Pereira de , Sousa Maria do Socorro Cordeiro de Sousa
Published: November 2021

Resumo: O presente trabalho analisa os desafios e as possibilidades da leitura e da escrita nos anos iniciais do ensino fundamental, como também destaca como desenvolver essas práticas numa concepção reflexiva por meio de suportes textuais adequados com a construção de sentidos. Para tanto, ao utilizar uma linguagem colaborativa na aprendizagem para uma compreensão crítica de mundo, deve-se conhecer e considerar métodos de leitura e escrita que possam facilitar a criatividade do indivíduo. Desse modo, faz-se necessário abordar a importância da leitura crítica para entender o mundo a nossa volta, no desejo de esclarecer o sentido das linguagens que nos cercam. Assim, concebe-se a linguagem como forma de interação e construção de sentido e defende-se a leitura e a escrita como práticas inerentes e substanciais para o processo de ensino-aprendizagem na escola, em especial nos anos iniciais. O aporte teórico para o desenvolvimento da pesquisa se ancora em estudos desenvolvodos por Solé (1998), Paulo Freire (1981, 1997, 1998 e 1996), Zabala (1998), Antunes (2009), Tiba (2012), Barbosa (2006), dentre outros. Este trabalho apresenta uma metodologia de caráter bibliográfico, descritivo, utilizando-se da abordagem de cunho qualitativo com o intuito de aprofundar os estudos da leitura e da escrita. Espera-se, dessa forma, contribuir para o ensino da leitura e da escrita nos anos iniciais, oferecendo alicerces para as aprendizagens significativas e, com isso, o domínio das inovações tecnológicas que o mundo das linguagens nos oferece. Palavras-Chave: Ensino Fundamental - Anos iniciais. Leitura. Escrita. Linguagem.
Édipo e Castração: Aspectos atinentes a constituição do sujeito / Oedipus and Castration: Aspects related to the constitution of the subject
Authors: Miguel Joelson Rodrigues , Braga Heuthelma Ribeiro
Published: November 2021

Resumo: O Complexo de Édipo é um processo constitutivo de todo sujeito, por meio do qual será desenvolvida sua estruturação psíquica, já que o conflito edipiano fica registrado no inconsciente de toda criança e persiste até o fim da vida. Vale lembrar que ao longo de seu desenvolvimento, o ego da criança vai sendo preparado para a castração por meio das diversas perdas que vai sofrendo, como o ventre da mãe, o seio materno e suas próprias fezes, surge então à ansiedade de castração que é justamente o medo de ser separado de um objeto valioso. O ensaio que se inscreve através de uma revisão bibliográfica visa discorrer sobre o Complexo de Édipo e a castração como aspectos atinentes a constituição do sujeito. A pesquisa trata-se de um estudo de natureza bibliográfica, com uma abordagem qualitativa e de cunho exploratório. Compreendemos através da pesquisa que o Complexo de Édipo assim como a castração tem sido cada vez mais pesquisado, no entanto, o que se percebe é que muitos estudos têm abordado esta temática sobre várias perspectivas, mas o que chama atenção é que ainda notam-se muitas divergências quanto ao assunto. Destarte, para nós da psicanálise é muito importante compreender esses conceitos fundamentais que foram nos colocado não só de compreensão por meio da psicanálise e através da ideia de Freud mais também por teóricos como Lacan que fez um retorno ao trabalho de Freud.Palavras-chave: Psicanálise; Complexo de Édipo. Castração; Criança.  Abstract: The Oedipus Complex is a constitutive process of every subject, through which its psychic structure will be developed since the oedipal conflict is registered in the unconscious of every child and persists until the end of life. It is worth remembering that throughout its development, the child's ego is being prepared for castration through the various losses it suffers, such as the mother's womb, the mother's breast, and her own feces, then the castration anxiety that is just the fear of being separated from a valuable object. The essay that is inscribed through a literature review aims to discuss the Oedipus Complex and castration as aspects related to the constitution of the subject. The research is a bibliographical study, with a qualitative and exploratory approach. We understand through the research that the Oedipus Complex as well as castration has been increasingly researched, however, what is perceived is that many studies have addressed this issue from various perspectives, but what draws attention is that it is still noticed. many disagreements on the subject. Thus, for us in psychoanalysis it is very important to understand these fundamental concepts that were brought to us not only through psychoanalysis and through Freud's idea, but also by theorists such as Lacan who made a return to Freud's work. Keywords: Psychoanalysis. Oedipus complex. Castration. Kid.
A Importância da Matemática no Desenvolvimento da Criança na Educação Infantil / The Importance of Mathematics in Child Development in Early Childhood Education
Authors: Souza Aywkslânia Nogueira de , Teixeira Verônica Rejane Lima
Published: November 2021

Resumo: O presente projeto tem como tema principal a ser abordado a importância da matemática na educação infantil, tendo como objetivos identificar os fatores que contribuem para essa aprendizagem e como as práticas lúdicas podem oferecer suporte para dinamizar e conscientizar dos benefícios de uma aprendizagem matemática. Para desenvolver esta pesquisa foi utilizada uma metodologia de caráter qualitativo com fontes de estudos bibliográficas, fundamentadas em autores que enfatizam a importância da aprendizagem matemática na educação infantil e em documentos que garantem os direitos de brincar da criança no âmbito escolar e em documentos como Referencial Curricular Nacional na Educação Infantil, A Lei de Diretrizes e Bases da Educação, Base Nacional Comum Curricular e Currículo de Pernambuco, com o intuito de aplicar uma visão aos educadores sobre a aprendizagem Matemática na Educação Infantil. Palavras chave: Matemática; Infantil; Criança; Aprendizagem.  Abstract: This project has as at main theme the importance of mathematics in early childhood education, aiming to identify the factors that contribute to this learning and how playful practices can provide support to boost and raise awareness of the benefits of learning mathematics. To develop this research, a qualitative methodology was used with sources of bibliographical studies, based on authors who emphasize the importance of mathematics learning in early childhood education and on documents that guarantee the children's rights to play in the school environment and on documents such as Curriculum Reference National in Early Childhood Education, The Law of Guidelines and Bases of Education, Common National Curriculum Base and Curriculum of Pernambuco, with the aim of applying a vision to educators on the learning of Mathematics in Early Childhood Education.Keywords: Mathematics; Children; Learning.
Entre os Direitos Culturais e a Ecologia Humana / Between Cultural Rights And Human Ecology
Authors: Souza Larissa Fernanda De Alencar , Santos Juracy Marques dos
Published: November 2021

Resumo: O trabalho em epígrafe visa discutir as relações que se estendem entre os direitos culturais e a Ecologia Humana. De forma bibliográfica e analítica, apresentamos o percurso que leva da definição de cultura aos direitos culturais. Dentro dessa discussão, analisamos a Declaração Universal dos Direitos Humanos como primeiro passo de promoção dos direitos culturais, importante para aprofundamento da discussão e extensão no devido debate. Num segundo momento, destacam-se os direitos culturais e políticas públicas culturais no Brasil, apresentando um histórico que passa pela constituição a aplicação de direitos culturais por meio das políticas públicas desenvolvidas. Por conseguinte, se discute a Ecologia humana em seu âmbito de Ecologia Cultural, em favor de analisar a importância de direitos culturais dentro desta matéria. Com base na Declaração de Friburgo, documento internacional que versa sobre a aplicação de direitos culturais, essa análise se dará através de 3 aspectos: a autodeterminação dos povos, o direito a identidade e patrimônio cultural, e os princípios de governança democrática. Assim, compreendemos que a ecologia humana cultural e os direitos culturais possuem uma relação mútua e interdependente para alcançar seus objetivos. Palavras-chave: Ecologia Cultural; Direitos Humanos; Autodeterminação dos Povos; Governança Democrática. Abstract: The above work aims to discuss the relationships that extend between cultural rights and Human Ecology. In a bibliographical and analytical way, we present the path that leads from the definition of culture to cultural rights. Within this discussion, we analyze the Universal Declaration of Human Rights as a first step in promoting cultural rights, which is important for deepening the discussion and extending the due debate. In a second moment, cultural rights and cultural public policies in Brazil stand out, presenting a history that goes through the constitution and application of cultural rights through the developed public policies. Therefore, human ecology is discussed in its scope of cultural ecology, in favor of analyzing the importance of cultural rights within this matter. Based on the Friborg Declaration, an international document that deals with the application of cultural rights, this analysis will be carried out through 3 aspects: the self-determination of peoples, the right to identity and cultural heritage, and the principles of democratic governance. Thus, we understand that cultural human ecology and cultural rights have a mutual and interdependent relationship to achieve their goals. Keywords: Cultural Ecology; Human Rights; Self-determination of People; Democratic Governance.
Utilização de modelos didáticos no ensino da anatomia humana da educação básica ao ensino superior / Use of didactic models in teaching human anatomy from basic education to higher education
Authors: Silva Tatiano Gomes da , Silva Taciane Laiane Gomes da , Silva Thaylane Gomes da
Published: November 2021

Resumo: Possuidora de um sistema educacional extremamente tecnicista, a educação brasileira ao longo dos anos necessitou de significativa reformulação de metodologias que facilitassem a aprendizagem dos estudantes. Nesse quesito, os estudos sobre novos métodos e mecanismos de ensino foram fomentados para a evolução significativa de conceitos. Assim, verificou-se a necessidade de produção e uso de modelos didáticos no ensino, especialmente na anatomia humana, por apresentar uma certa complexidade de termos que na maioria das vezes dificultam a apreensão dos estudantes. Nesse aspecto, o presente artigo tem o objetivo de fazer uma análise sistemática da utilização de modelos didáticos na abordagem da anatomia humana na educação básica e superior, visando perceber o quanto é importante o uso de tais instrumentos pedagógicos para o ensino e aprendizagem da anatomia humana. Assim, a utilização de modelos didáticos no ensino da anatomia humana torna-se uma verdadeira ferramenta que facilita a aprendizagem de forma mais dinâmica. Palavras-chave: Anatomia Humana. Modelos Didáticos. Metodologias Ativas em Anatomia. EnsinoAbstract: Possessing an extremely technicist educational system, Brazilian education over the years required a significant reformulation of methodologies that facilitated student learning. In this regard, studies on new teaching methods and mechanisms were encouraged for the significant evolution of concepts. Thus, there was a need for the production and use of didactic models in teaching, especially in human anatomy, as they present a certain complexity of terms that most often make it difficult for students to understand. In this aspect, this article aims to make a systematic analysis of the use of didactic models in the approach of human anatomy in basic and higher education, aiming to realize how important the use of such pedagogical tools is for the teaching and learning of human anatomy. Thus, the use of didactic models in teaching human anatomy becomes a real tool that facilitates learning in a more dynamic way. Keywords: Human Anatomy. Didactic Models. Active Methodologies in Anatomy. Teaching.
Anais do VI Congresso de Saúde da Mulher do Cariri - SAÚDE MENTAL / Proceedings of the VI Cariri Women's Health Congress - MENTAL HEALTH
Authors: Brayner Patrícia Maria De Albuquerque , Oliveira Tainã Brito Siebra de , Feitosa Neto José De Araújo , Lima Brena Suianne Pereira , Macedo Lorena Magalhães de
Published: November 2021

O Congresso de Saúde da Mulher do Cariri (CONSMUC) é organizado anualmente pelo Programa de Atenção à Gestante (ProGest), projeto de extensão vinculado à Faculdade de Medicina da Universidade Federal do Cariri, sob orientação da professora efetiva do curso de medicina Patrícia Maria de Albuquerque Brayner. O congresso aborda temáticas importantes na área de Saúde da Mulher. Esse ano, em sua VI edição, foi realizado nos dias 1 a 3 de Outubro de 2021 em versão on- line, abordando como temática principal a “Saúde Mental”. Palavras-Chave: Saúde da Mulher; Congresso; Saúde MentalAbstract: The Cariri Women's Health Congress (CONSMUC) is organized annually by the Pregnancy Care Program (ProGest), an extension project linked to the Faculty of Medicine of the Federal University of Cariri, under the guidance of the effective professor of the medicine course, Patrícia Maria de Albuquerque Brayner.  The congress addresses important themes in the area of Women's Health.  This year, in its VI edition, it was held from October 1st to 3rd, 2021 in an online version, addressing as the main theme “Mental Health”.Keywords: Women´s Health; Congress; Mental Health
Identification and Characterization of Different Types of Plastics Wastes Using X-Ray Diffraction and X-Ray Fluorescence Techniques
Authors: Abubaker Shawbo A. , Chaqmaqchee Faten A. , Taha Akram H.
Published: October 2021

In this study, different types of polymers in postconsumer plastics with pure plastics have been studied. Highdensity polyethylene (HDPE1 and HDPE2), polyvinyl chloride (PVC3 and PVC4), polyethylene terephthalate (PET5 and PET6), and polypropylenes (PP7 and PP8) were compared using X-ray diffraction (XRD) and X-ray fluorescence (XRF) techniques. XRF has shown the spectral in K-lines of polymer materials present in plastics waste. The peak intensity and degree of crystallinity of commercial polymers are varied using XRD analysis. The intensity not attributable to the crystalline peaks may be regarded as the amorphous scattering and used as a template in analyzing the diffraction pattern of the samples. The XRD analysis helps to provide characteristic spectral lines whose intensities vary with the type of each constituent polymer. The combined usage of XRD and XRF techniques yielded very useful and effective results for a commercial plastic management.
Resistir la heterosexualización en la educación secundaria: Tensiones relativas a la inclusión LGTB+ en Chile
Authors: Catherine Galaz  , Troncoso Lelya , Bravo Sofía
Published: November 2021

Durante los últimos años se ha incrementado la visibilización de personas y colectivos LGTB+ en el ámbito educacional en Chile. Las demandas relacionadas con diversidad sexual se suelen articular en torno a la idea de inclusión de estudiantes LGTB+. En este artículo analizamos discursos y prácticas sobre inclusión LGTB+ en el sistema educacional público chileno, a partir de entrevistas individuales y grupales realizadas entre los años 2018 y 2019 con personas interventoras y usuarias en las regiones de Santiago, Valparaíso y Concepción. Nuestro objetivo es problematizar ciertos usos liberales de la inclusión y sus efectos negativos a la hora de afirmar y apoyar efectivamente a las diversidades y disidencias sexuales. Los principales resultados del análisis de discurso de las entrevistas se presentan en cuatro ejes: tensiones en la implementación de prácticas educativas de inclusión; pánicos morales y fijaciones heterocisnormativas; intervenciones identitarias y reduccionistas; y, desestabilización de las fronteras desde los activismos LGTB+.
Lo trans en el cole: Cuerpos, discursos y miradas. Algunas reflexiones sobre contexto costarricense
Authors: Fernández Daniel Fernández
Published: November 2021

En este artículo se desarrolla un análisis de las formaciones discursivas de docentes y estudiantes de secundaria pertenecientes al sistema educativo costarricense en torno a la presencia de personas transgénero en el colegio. En términos teóricos, se parte de los postulados analíticos de la teoría queer, como una vía para analizar las complejidades que conllevan la construcción de la identidad trans, sin por lo tanto adscribirse a un modelo unívoco de interpretación del género y la sexualidad. En términos metodológicos, la investigación que da pie al presente texto se planteó desde un abordaje cualitativo. En lo que se refiere al trabajo de campo se efectuaron entrevistas semiestructuradas y para el análisis de la información, se realizó un análisis discursivo de orientación foucaultiana. Los resultados muestran que el binarismo sexual hombre – mujer, así como la fijeza de los roles de género continúan repercutiendo de manera considerable en la forma en la que se mira el cuerpo trans en el escenario biopolítico del colegio.
A path is emerging: Steps towards an LGBT+ inclusive education for Mexican students
Authors: Valderrábano Jorge Herrera , Cai Thomas  , Cody Freeman
Published: November 2021

Mexican schools are in crisis, where LGBT+ students face constant violence and discrimination. In the past decade, civil society has led the way in evaluating school climate and assessing LGBT+ students’ needs in Mexican schools. Unsurprisingly, individuals most affected by this violence and discrimination, LGBT+ individuals, have pushed these efforts forward as they conduct research, create resources, and facilitate workshops. In this article, we show how civil society has been the leader on advocating for LGBT+ inclusive education in Mexico. We justify this claim by exploring the existing research at the national, regional, and international levels, showing that much of what is present stems from civil society’s ongoing efforts. We then analyze the current legal framework aimed at protecting students against discrimination. We also discuss existing tools and advancements designed to promote inclusive classrooms, from both a public policy and civil society perspective. We conclude by punctuating the necessity and urgency of utilizing civil society in reforms that advocate for inclusion to better formulate public policies and establish direct, sustainable ties to the individuals and communities most in need.
Analisis Faktor-Faktor Yang Berpengaruh Dalam Pemilihan Lokasi Relokasi Pedagang Kaki Lima di Kawasan Pasar Pagi, Kota Samarinda
Authors: Demas Kristia Liendika Arruan Minanga
Published: November 2021

Sesuai dengan program prioritas RPJMD Kota Samarinda tahun 2016-2021 dalam penataan Pedagang Kaki Lima di kawasan perdagangan dan jasa, bentuk usaha yang sudah diterpakan dalam upaya penataan Pedagang Kaki Lima di kawasan Pasar Pagi dengan melakukan penertiban dan penggusuran. Namun yang menjadi permasalahan adalah karena Pedagang Kaki Lima yang telah digusur terus kembali pada lokasi yang sama untuk berdagang. Sehingga sebagai salah satu langkah awal dalam penataan maka perlu adanya identifikasi karakteristik PKL serta analisis faktor-faktor yang berpengaruh dalam pemilihan lokasi untuk relokasi bagi Pedagang Kaki Lima di kawasan Pasar Pagi. Metode yang digunakan adalah statistik deskrptif dan analisis Delphi. Hasil menunjukkan bahwa karakteristik PKL di Pasar Pagi teridentifikasi dalam tiga kelompok yang dibagi berdasarkan jenis dagangan yaitu Kelompok I, Makanan/Minuman Siap Saji; Kelompok II : Non-Makanan, Kelompok III : Jasa dan faktor-faktor yang berpengaruh dalam penataan pedagang kaki lima berdasarkan perspektif stakeholders yaitu (1) Sirkulas; (2) Dekat Permukiman; (3) Aksesibilitas; (4) Ekspansi; (5) Lahan Parkir; (6) Jaringan Listrik; (7) Jaringan Air Bersih; (8) Jaringan Limbah; (9) Lingkungan; (10) Visibilitas; (11) Fungsi Jalan; (12) Akses Pejalan Kaki dan (13) Kebijakan Tata Ruang.
Peculiarities of the police officer's profession image in their attitude
Authors: Dobrzinskiene Rasa , Pauriene Giedre , Kushnir Iryna , Grytsyshen Dimitri , Malyshev Kostiantyn
Published: November 2021

Aspects of choosing a profession and career planning are closely related to the description of the features of the image of the profession, otherwise known as the image of the profession. The choice of profession is an essential part of life, which has a significant influence upon the person and their further occupation. Furthermore, the choice of profession and job is related to the satisfaction of financial, social and personal needs. Therefore, it is very important that the choice of profession is as accurate as possible and that the profession evokes a strong feeling of vocation. A career develops accordingly, if a person is satisfied with the job and one’s current expectations meet the current situation, then the career development is successful and thrives as individually sought. For a career to follow a successful developing process it is vital to meticulously systematize the characteristics of a particular profession that would help to decide whether one wants to choose it not. Due to these reasons whilst researching the police officer’s image it is crucial to assess the point of view of current police officers in regard to the officer’s image. Correspondingly, the purpose of the article is evoked - to reveal the perception of police officers of the image of their profession. To achieve it, the concept of choosing a profession is discussed, emphasizing the importance of vocation and the path of professional development - career; the change in the attitude of police officers about the image of their profession and its factors are determined. The hypotheses are confirmed disparately. After an empirical study, the first hypothesis - the average of the respondents' assessment of the current attitude towards the characteristics of the police officer profession is statistically significantly different from the attitude before choosing this profession - was confirmed. The second hypothesis was only partly confirmed. It was revealed that the average assessment of the characteristics of the police profession for both men and women decreases depending on the degree of the police officer.
Tumor cell lysis and synergistically enhanced antibody-dependent cell-mediated cytotoxicity by NKG2D engagement with a bispecific immunoligand targeting the HER2 antigen
Authors: Kellner Christian , Lutz Sebastian , Oberg Hans-Heinrich , Wesch Daniela , Otte Anna , Diemer Katarina J. , Wilcken Hauke , Bauerschlag Dirk , Glüer Claus-Christian , Wichmann Christian , Kabelitz Dieter , Leusen Jeanette H. W. , Klausz Katja , Humpe Andreas , Gramatzki Martin , Peipp Matthias
Published: October 2021

Natural killer group 2 member D (NKG2D) plays an important role in the regulation of natural killer (NK) cell cytotoxicity in cancer immune surveillance. With the aim of redirecting NK cell cytotoxicity against tumors, the NKG2D ligand UL-16 binding protein 2 (ULBP2) was fused to a single-chain fragment variable (scFv) targeting the human epidermal growth factor receptor 2 (HER2). The resulting bispecific immunoligand ULBP2:HER2-scFv triggered NK cell-mediated killing of HER2-positive breast cancer cells in an antigen-dependent manner and required concomitant interaction with NKG2D and HER2 as revealed in antigen blocking experiments. The immunoligand induced tumor cell lysis dose-dependently and was effective at nanomolar concentrations. Of note, ULBP2:HER2-scFv sensitized tumor cells for antibody-dependent cell-mediated cytotoxicity (ADCC). In particular, the immunoligand enhanced ADCC by cetuximab, a therapeutic antibody targeting the epidermal growth factor receptor (EGFR) synergistically. No significant improvements were obtained by combining cetuximab and anti-HER2 antibody trastuzumab. In conclusion, dual-dual targeting by combining IgG1 antibodies with antibody constructs targeting another tumor associated antigen and engaging NKG2D as a second NK cell trigger molecule may be promising. Thus, the immunoligand ULBP2:HER2-scFv may represent an attractive biological molecule to promote NK cell cytotoxicity against tumors and to boost ADCC.
Maternal oxytocin administration modulates gene expression in the brains of perinatal mice
Authors: Hsieh Frances F. , Korsunsky Ilya , Shih Andrew J. , Moss Matthew A. , Chatterjee Prodyot K. , Deshpande Jaai , Xue Xiangying , Madankumar Swati , Kumar Gopal , Rochelson Burton , Metz Christine N.
Published: October 2021

Objectives

Oxytocin (OXT) is widely used to facilitate labor. However, little is known about the effects of perinatal OXT exposure on the developing brain. We investigated the effects of maternal OXT administration on gene expression in perinatal mouse brains.

Methods

Pregnant C57BL/6 mice were treated with saline or OXT at term (n=6–7/group). Dams and pups were euthanized on gestational day (GD) 18.5 after delivery by C-section. Another set of dams was treated with saline or OXT (n=6–7/group) and allowed to deliver naturally; pups were euthanized on postnatal day 9 (PND9). Perinatal/neonatal brain gene expression was determined using Illumina BeadChip Arrays and real time quantitative PCR. Differential gene expression analyses were performed. In addition, the effect of OXT on neurite outgrowth was assessed using PC12 cells.

Results

Distinct and sex-specific gene expression patterns were identified in offspring brains following maternal OXT administration at term. The microarray data showed that female GD18.5 brains exhibited more differential changes in gene expression compared to male GD18.5 brains. Specifically, Cnot4 and Frmd4a were significantly reduced by OXT exposure in male and female GD18.5 brains, whereas Mtap1b, Srsf11, and Syn2 were significantly reduced only in female GD18.5 brains. No significant microarray differences were observed in PND9 brains. By quantitative PCR, OXT exposure reduced Oxtr expression in female and male brains on GD18.5 and PND9, respectively. PC12 cell differentiation assays revealed that OXT induced neurite outgrowth.

Conclusions

Prenatal OXT exposure induces sex-specific differential regulation of several nervous system-related genes and pathways with important neural functions in perinatal brains.
Enhanced S100B expression in T and B lymphocytes in spontaneous preterm birth and preeclampsia
Authors: Busse Mandy , Scharm Markus , Oettel Anika , Redlich Anke , Costa Serban-Dan , Zenclussen Ana Claudia
Published: October 2021

Objectives

S100B belongs to the family of danger signaling proteins. It is mainly expressed by glial-specific cells in the brain. However, S100B was also detected in other cell likewise immune cells. This molecule was suggested as biomarker for inflammation and fetal brain damage in spontaneous preterm birth (sPTB), preeclampsia (PE) and HELLP (hemolysis, elevated liver enzymes, and low platelet count).

Methods

The aim of our study was to determine the concentration of S100B in maternal and cord blood (CB) plasma and placenta supernatant as well as the expression of S100B in maternal and CB CD4+ T cells and CD19+ B cells in sPTB and patients delivering following PE/HELLP diagnosis compared to women delivering at term (TD). The S100B expression was further related to the birth weight in our study cohort.

Results

S100B concentration was enhanced in maternal and CB plasma of sPTB and PE/HELLP patients and positively correlated with interleukin-6 (IL-6) levels. Increased S100B was also confirmed in CB of small-for-gestational-age (SGA) infants. S100B expression in maternal blood was elevated in CD4+ T cells of PE/HELLP patients and patients who gave birth to SGA newborns as well as in CD19+ B cells of sPTB and PE/HELLP patients and patients with SGA babies. In CB, the expression of S100B was increased in CD19+ B cells of sPTB, PE/HELLP and SGA babies.

Conclusions

Our results support the hypothesis that S100B expression is enhanced in inflammatory events associated with preterm birth and that S100B expression in immune cells is a relevant marker for inflammation during pregnancy complications.
Dressed emitters as impurities
Authors: Leonforte Luca , Valenti Davide , Spagnolo Bernardo , Carollo Angelo , Ciccarello Francesco
Published: October 2021

Dressed states forming when quantum emitters or atoms couple to a photonic bath underpin a number of phenomena and applications, in particular nonradiating effective interactions occurring within photonic bandgaps. Here, we present a compact formulation of the resolvent-based theory for calculating atom-photon dressed states built on the idea that the atom behaves as an effective impurity. This establishes an explicit connection with the standard impurity problem in condensed matter. Moreover, it allows us to formulate and settle – independently of the bath Hamiltonian – a number of properties previously known only for specific models or not entirely formalized. The framework is next extended to the case of more than one emitter, which is used to derive a general expression of dissipationless effective Hamiltonians explicitly featuring the overlap of single-emitter dressed bound states.
Dorsomedial Striatal Activity Tracks Completion of Behavioral Sequences in Rats
Authors: Vandaele Youna , Ottenheimer David J. , Janak Patricia H.
Published: November 2021

For proper execution of goal-directed behaviors, individuals require both a general representation of the goal and an ability to monitor their own progress toward that goal. Here, we examine how dorsomedial striatum (DMS), a region pivotal for forming associations among stimuli, actions, and outcomes, encodes the execution of goal-directed action sequences that require self-monitoring of behavior. We trained rats to complete a sequence of at least five consecutive lever presses (without visiting the reward port) to obtain a reward and recorded the activity of individual cells in DMS while rats performed the task. We found that the pattern of DMS activity gradually changed during the execution of the sequence, permitting accurate decoding of sequence progress from neural activity at a population level. Moreover, this sequence-related activity was blunted on trials where rats did not complete a sufficient number of presses. Overall, these data suggest a link between DMS activity and the execution of behavioral sequences that require monitoring of ongoing behavior.
Information supply of the power control system of the synchronous generator of the autonomous wind unit
Authors: Ostroverkhov Mykola Ya. , Chumack Vadim V. , Monakhov Yevhen A. , Pryymak Bogdan I.
Published: November 2021

This paper deals with information supply of automatic maximum power control system of synchronous hybrid excited genera-tor for the autonomous wind unit. The power supply system based on an autonomous wind turbine consists of an electric generator, a battery charging controller, a battery pack and an inverter, which provides the required frequency and valueof the consumer's supply voltage.Three phase permanent magnet synchronous generator that have high technical and economic indicators are most widely used as electric generator of autonomous wind turbines.The main disadvantage of these generators is the lack of effective methods of magnetic flux control, limiting the optimization of the energy balance of the wind turbine.The paper discusses the application of synchronous generator with hybrid excitation system that consists of permanent magnets and additional field excitation winding lo-cated on the stator. Mathematical model of a hybrid excited synchronous generator is presented. Also,an output maximum power control system in a case of wind speed change by varying field excitation current is developed. Control system is developed based on concept of reverse task of dynamics in combination with minimization of local functionals of instantaneous values of energies.In the basics of the control method is put an idea of the reversibility of the Lyapunov direct method for the stability analysis.Obtained con-trol law provides thesystem stability inwhole, which allows solving control tasks of interrelated objects via mathematical models of local loops. Control law also provides low sensitiveness to parametric disturbances and gives dynamic decomposition of interrelated non linear system that ensures its practical implementation. The study of the proposed power control system based on parameters of hybrid excited synchronous generatorexperimental sample has been carried out. The graphs of transient process of armature power, voltage and current in a case of wind speed change from 3 to 8 m/s were obtained, as well as in a case of active resistance load change. The results of study showed high efficiency of power control of a wind turbine with hybrid excited synchronous generator.
Las paradojas financieras del abastecimiento de Larache y Mamora: presidios, logística militar y aristocracia, 1611-1635
Authors: Salas Almela Luis
Published: November 2021

Este artículo analiza en primer lugar las circunstancias que condujeron a que la vigilancia y mantenimiento de los presidios de Larache y Mamora quedasen vinculadas desde su conquista —en 1611 y 1614 respectivamente— hasta 1641 a los duques de Medina Sidonia. A lo largo de este periodo, la falta de concreción administrativa de este cometido asumido por los aristócratas andaluces fue el origen de conflictos y fricciones con la corte regia que pusieron de manifiesto la paradójica situación creada, según la cual cuanto mayor era la autonomía de mando que iban alcanzando los duques, mayor era el esfuerzo económico que les suponía, pese a sus reiteradas demandas para que se encontrase una solución financiera estable. Así mismo, se analizan algunos expedientes que se ensayaron para tratar de alcanzar un equilibrio. Una serie de esfuerzos que el experimento de la contribución única de la sal terminó obligando a abandonar en 1631-1635.
La rivalidad como enemigo. El rendimiento del Ejército de Flandes en el sitio de Ostende, 1601-1604
Authors: Thomas Werner
Published: November 2021

Durante más de tres años el Ejército de Flandes intentó tomar Ostende, último reducto de la República holandesa en los Países Bajos meridionales. La ubicación de la ciudad, su continuo abastecimiento por el mar, las condiciones atmosféricas, las características del terreno, las diversiones organizadas por Mauricio de Nassau, todos estos elementos dificultaron la toma de la ciudad. Pero no explican todo. La rivalidad entre los cabos y naciones del Ejército, apenas controlada por el capitán general, también desempeñaron un papel principal. Este artículo analiza su rol en el bajo rendimiento de las tropas ante Ostende.