bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations between condylar height relative to occlusal plane and condylar osseous condition and TMJ loading based on 3D measurements and finite element analysis
Authors: Gong Yanji , Zhu Jinyi , Zheng Fangjie , Zhu Yunfan , Sui Shangyan , Liu Yang , Yin Deqiang
Published: November 2024

To investigate the relationship between condylar height relative to occlusal plane (CHO) and condylar osseous condition and the changes of condylar stress loading before and after CHO modifications. The condylar osseous conditions of 434 temporomandibular joints (TMJ) were assessed and grouped. Measurements of anatomical parameters were performed on CT-based reconstructed 3D stomatognathic models. Differences in anatomical parameters of the jaws in the different groups were compared, and the correlation between the Angle α (representing the CHO ratio) and related parameters was investigated. A finite element model (FEM) was constructed using 3D finite element analysis (FEA). The Angle α was altered by modifying condylar position and the inclination of mandibular plane (MP) and occlusal plane (OP) based on the FEM to analyze condylar stress loading under different working conditions. There were differences in anatomical parameters among the different groups, with the smaller Angle α in the osseous destruction group. Angle α was negatively correlated with the inclination of MP and OP. The FEA illustrated condylar stress loading changed after modifying the Angle α by both two modalities. After modifying condylar position, the stress increased with the proximal movement of the condyle toward the OP. After changing the inclination of MP and OP, the stress increased with increasing inclinations. Changes in CHO correlate with condylar osseous condition, and distal movement of the condyle to the OP and reduction of MP and OP inclination may reduce TMJ stress overload. In clinical practice, it is advisable to assess patients for sufficient CHO ratio, as insufficiency in CHO may elevate the risk of TMJ stress overload. The CHO ratio could be modulated by changing the inclination of the OP.
The optimal formulation of a readily compostable horticultural growing substrate for vertical farming was determined using design of experiments
Authors: Romo Jonathan M. , Smith Isabel N. , Galloway Michael , Cuthbertson Timothy J.
Published: November 2024

A novel, optimized, polysaccharide and biochar-based, compostable hydrogel horticultural growing substrate for use in hydroponics and vertical farming was created based upon empirical methods and statistical design of experiments. A 15-run D-optimal mixture design of experiments was completed that increased the 14-day plant growing ability of a five-component hydrogel nearly ten-fold from 4.3695 g to 41.2623 g per 100 plants. The data were analyzed using a standard least squares method with an effect screening emphasis, and a model was created that maximized the signal to noise ratio. There was a good correlation between the measured and predicted values of the model, with an r-squared value of 0.90. The predictions of efficacy and compostability were confirmed with subsequent experiments that showed the hydrogel was composted in less than 84 days and that the plant growth predicted by the model differed from the experimental growth by 0.65%. The resulting optimized formulation had a high fertilizer content for a growth medium. We therefore suggest that an empirical approach to formulation research can produce superior outcomes with a statistically designed study.
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome
Authors: Pan Hui , Tian Ai-Ling , Chen Hui , Xia Yifan , Sauvat Allan , Moriceau Stephanie , Lambertucci Flavia , Motiño Omar , Zhao Liwei , Liu Peng , Mao Misha , Li Sijing , Zhang Shuai , Joseph Adrien , Durand Sylvère , Aprahamian Fanny , Luo Zeyu , Ou Yang , Shen Zhe , Xue Enfu , Pan Yuhong , Carbonnier Vincent , Stoll Gautier , Forveille Sabrina , Leduc Marion , Cerrato Giulia , Cerone Alexandra , Maiuri Maria Chiara , Castinetti Frederic , Brue Thierry , Wang Hongsheng , Ma Yuting , Martins Isabelle , Kepp Oliver , Kroemer Guido
Published: November 2024

Cushing’s syndrome is caused by an elevation of endogenous or pharmacologically administered glucocorticoids. Acyl coenzyme A binding protein (ACBP, encoded by the gene diazepam binding inhibitor, Dbi) stimulates food intake and lipo-anabolic reactions. Here we found that plasma ACBP/DBI concentrations were elevated in patients and mice with Cushing’s syndrome. We used several methods for ACBP/DBI inhibition in mice, namely, (1) induction of ACBP/DBI autoantibodies, (2) injection of a neutralizing monoclonal antibody, (3) body-wide or hepatocyte-specific knockout of the Dbi gene, (4) mutation of the ACBP/DBI receptor Gabrg2 and (5) injections of triiodothyronine or (6) the thyroid hormone receptor-β agonist resmetirom to block Dbi transcription. These six approaches abolished manifestations of Cushing’s syndrome such as increased food intake, weight gain, excessive adiposity, liver damage, hypertriglyceridaemia and type 2 diabetes. In conclusion, it appears that ACBP/DBI constitutes an actionable target that is causally involved in the development of Cushing’s syndrome.
Seasonality and climate modes influence the temporal clustering of unique atmospheric rivers in the Western U.S
Authors: Yang Zhiqi , DeFlorio Michael J. , Sengupta Agniv , Wang Jiabao , Castellano Christopher M. , Gershunov Alexander , Guirguis Kristen , Slinskey Emily , Guan Bin , Delle Monache Luca , Ralph F. Martin
Published: November 2024

Atmospheric rivers (ARs) are narrow corridors of intense water vapor transport, shaping precipitation, floods, and economies. Temporal clustering of ARs tripled losses compared to isolated events, yet the reasons behind this clustering remain unclear. AR orientation further modulates hydrological impacts through terrain interaction. Here we identify unique ARs over the North Pacific and Western U.S. and utilize Cox regression and composite analysis to examine how six major climate modes influence temporal clustering of unique ARs and orientation during extended boreal winter (November to March). Results show that climate modes condition temporal clustering of unique ARs. The Pacific-North American weather pattern strongly modulates the clustering over the Western U.S. from early to late winter. The quasi-biennial oscillation and Pacific decadal oscillation affect late winter clustering, while the Arctic oscillation dominates early winter. Climate modes also strongly influence AR orientation, with ENSO particularly affecting the orientation of temporally clustered ARs.
National ecosystem restoration pledges are mismatched with social-ecological enabling conditions
Authors: Benra Felipe , Brück Maria , Sigman Emily , Pacheco-Romero Manuel , Shumi Girma , Abson David J. , Frietsch Marina , Fischer Joern
Published: November 2024

Ecosystem restoration is widely recognized as a key strategy to address social-ecological challenges. National governments have pledged to restore millions of hectares of land. However, the ability to accomplish these pledges remains opaque, because restoration efforts are influenced by complex social-ecological factors. We provide a global analysis of national-level enabling and hindering conditions and their relation to restoration pledges undertaken by different nations. We developed an archetype characterization of within-country conditions using biophysical, socio-economic and governance indicators. Additionally, we investigated between-country conditions by examining flows of embodied land. Our analysis suggests that the countries with the most ambitious restoration pledges also tend to have the weakest enabling conditions (and vice versa). These results highlight the need to account for social, economic and governance factors alongside biophysical factors when considering where restoration ought to take place.
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway
Authors: Brauer Berit K , Chen Zilei , Beirow Felix , Li Jiaran , Meisinger Daniel , Capriotti Emanuela , Schweizer Michaela , Wagner Lea , Wienberg Jascha , Hobohm Laura , Blume Lukas , Qiao Wenjie , Narimatsu Yoshiki , Carette Jan E , Clausen Henrik , Winter Dominic , Braulke Thomas , Jabs Sabrina , Voss Matthias
Published: November 2024

Glycosylation, which plays an important role in modifying lipids and sorting of proteins, is regulated by asymmetric intra-Golgi distribution and SPPL3-mediated cleavage of Golgi enzymes. We found that cells lacking LYSET/TMEM251, a retention factor for Golgi N-acetylglucosamine-1-phosphotransferase (GNPT), display SPPL3-dependent hypersecretion of the Golgi membrane protein B4GALT5. We demonstrate that in wild-type cells B4GALT5 is tagged with mannose 6-phosphate (M6P), a sorting tag typical of soluble lysosomal hydrolases. Hence, M6P-tagging of B4GALT5 may represent a novel degradative lysosomal pathway. We also observed B4GALT5 hypersecretion and prominent destabilization of LYSET–GNPT complexes, impaired M6P-tagging, and disturbed maturation and trafficking of lysosomal enzymes in multiple human cell lines lacking the COPI adaptors GOLPH3 and GOLPH3L. Mechanistically, we identified LYSET as a novel, atypical client of GOLPH3/GOLPH3L. Thus, by ensuring the cis-Golgi localization of the LYSET–GNPT complex and maintaining its Golgi polarity, GOLPH3/GOLPH3L is essential for the integrity of the M6P-tagging machinery and homeostasis of lysosomes.
BBSome-deficient cells activate intraciliary CDC42 to trigger actin-dependent ciliary ectocytosis
Authors: Prasai Avishek , Ivashchenko Olha , Maskova Kristyna , Bykova Sofiia , Schmidt Cernohorska Marketa , Stepanek Ondrej , Huranova Martina
Published: November 2024

Bardet-Biedl syndrome (BBS) is a pleiotropic ciliopathy caused by dysfunction of the BBSome, a cargo adaptor essential for export of transmembrane receptors from cilia. Although actin-dependent ectocytosis has been proposed to compensate defective cargo retrieval, its molecular basis remains unclear, especially in relation to BBS pathology. In this study, we investigated how actin polymerization and ectocytosis are regulated within the cilium. Our findings reveal that ciliary CDC42, a RHO-family GTPase triggers in situ actin polymerization, ciliary ectocytosis, and cilia shortening in BBSome-deficient cells. Activation of the Sonic Hedgehog pathway further enhances CDC42 activity specifically in BBSome-deficient cilia. Inhibition of CDC42 in BBSome-deficient cells decreases the frequency and duration of ciliary actin polymerization events, causing buildup of G protein coupled receptor 161 (GPR161) in bulges along the axoneme during Sonic Hedgehog signaling. Overall, our study identifies CDC42 as a key trigger of ciliary ectocytosis. Hyperactive ciliary CDC42 and ectocytosis and the resulting loss of ciliary material might contribute to BBS disease severity.
Cyclic natural product oligomers: diversity and (bio)synthesis of macrocycles
Authors: Zhang Songya , Fan Shuai , He Haocheng , Zhu Jing , Murray Lauren , Liang Gong , Ran Shi , Zhu Yi Zhun , Cryle Max J. , He Hai-Yan , Zhang Youming
Published: November 2024

This graphical abstract compares enzymatic and chemical macrocyclization of cyclic natural product oligomers, highlighting bacterial, fungal, and plant enzymes, alongside chemical methods like ring-closing metathesis, lactonization, disulfide bridges, and cycloaddition.
A novel ratiometric fluorescent probe based on an internal reference of lanthanide/nucleotide for alkaline phosphatase detection
Authors: Yu Haoran , Qiang Ziqing , Sun Yelin , Sun Mengyao , Zhang Lei , Yu Bohao , Lei Wen , Zhang Weibing
Published: November 2024

A novel biocompatible ratiometric lanthanide fluorescent probe based on an internal reference (CIP@SiO2-Ce/ATP-Tris) was constructed for alkaline phosphatase detection.
Unlocking the access to nature-identical vanillin via isoeugenol ozonation: in situ ATR-IR monitoring and safety evaluation
Authors: Zhao Yun , Li Tingfei , Xie Sisi , Zhang Pingyi , Mao Haifang
Published: November 2024

A green, catalyst-free synthesis method for nature-identical vanillin achieved 96.86% yield, monitored through in situ ATR-IR spectroscopy, maximizing efficiency, enhancing sustainability and reducing environmental impact.
Electrochemical lithium-ion insertion/extraction reactions of multilayered graphene with random twist angles
Authors: Yamamoto Satoshi , Sakakibara Ryotaro , Shima Soichi , Matsuura Shinsuke , Yajima Takeshi , Motoyama Munekazu , Norimatsu Wataru , Kimura Yuta , Amezawa Koji , Iriyama Yasutoshi
Published: November 2024

A multilayer graphene film with random twist angles between layers (TAGr) on SiC(0001̄) shows six pairs of redox peaks for Li+ insertion/extraction reaction.
Porous MOFs with geometric mismatch between trimers and octatopic pyrene-based ligands for low-temperature methane storage
Authors: Wang Kun , Cao Honghao , Zhong Yuanlong , Yang Zhenning , Shi Hancheng , Xiong Zhangyi , Mu Yuqiao , Chen Zhijie
Published: November 2024

We synthesized porous metal–organic frameworks with a geometric mismatch strategy for high-capacity low-temperature methane adsorption, which is important for efficiently utilizing boil-off gas.
Exploring novel cocrystals of milrinone: a cardioprotective drug combined with nutraceuticals and an NSAID
Authors: Kenguva Gowtham , Rekha Rout Smruti , Shaikh Tabrez R. , Baidya Debjani , Shelke Nikita , Sanphui Palash , Dandela Rambabu
Published: November 2024

Three novel cocrystals of milrinone with sesamol, resveratrol, and niflumic acid were synthesized, with MR.SES showing enhanced solubility and potential for improved cardioprotective effects.
Evolution of Mo species and ZSM-5 microstructure with temperature and its impact on methane dehydroaromatisation activity
Authors: Cong Peixi , Lezcano-Gonzalez Ines , Longo Alessandro , Bras Wim , Beale Andrew M.
Published: November 2024

Wavelet analysis on Mo K-edge data from Mo-ZSM-5 reveals the presence of mononuclear sites after activation and subsequent zeolite collapse.
Unveiling ultraviolet photodissociation dynamics of SiO from a laser-ablated supersonic beam with time-sliced ion velocity imaging
Authors: Ma Yujie , Li Fangfang , Yan Dong , Xu Ang , Zhou Ti , Liu Jiaxing , Wang Fengyan
Published: November 2024

We have successfully observed the ultraviolet photodissociation dynamics of SiO from vibrationally and electronically excited states with a bonding energy of De(Si–O) up to 8.34 eV using laser ablation and time-sliced ion velocity imaging.
Data-driven analysis of text-mined seed-mediated syntheses of gold nanoparticles
Authors: Lee Sanghoon , Cruse Kevin , Gleason Samuel P. , Alivisatos A. Paul , Ceder Gerbrand , Jain Anubhav
Published: November 2024

Gold nanoparticle synthesis recipes were extracted from the literature to obtain data-driven hypotheses for synthesis outcome morphology and size. Used images from https://Flaticon.com.
Square planar Pd(ii)/oximate complexes as ‘metalloligands’ for the directional assembly of 4f-metal ions: a new family of {Ln2Pd} (Ln = lanthanide) clusters exhibiting slow magnetization relaxation
Authors: Pantelis Konstantinos N. , Raptopoulou Catherine P. , Psycharis Vassilis , Tang Jinkui , Stamatatos Theocharis C.
Published: November 2024

An unexplored strategy based on the [Pd(pao)2] ‘metalloligand’ has been developed towards the controlled synthesis of a family of [Ln2Pd(pao)2(NO3)6(MeOH)2(H2O)2] complexes with a linear conformation and field-induced relaxation of magnetization.
Ultrasonic spraying of Ce(Mn,Fe)O2 nanocatalysts onto a perovskite surface for highly efficient electrochemical CO2 reduction
Authors: Lee Sang Won , Nam Tae Heon , Lee Seok Hee , Ishihara Tatsumi , Irvine John T. S. , Shin Tae Ho
Published: November 2024

We propose an ultrasonic spraying strategy for the one-step fabrication of uniform nano-electrodes with a nano-convex structure on an all-ceramic fuel electrode, enhancing both activity and durability.
A glutenin protein corona ameliorated TiO2 nanoparticle-induced gut barrier dysfunction and altered the gut microbiota composition
Authors: Mi Shichao , Shen Mingyang , Liu Zimo , Yu Yingying , Shan Honghong , Cao Jin , McClements David Julian , Cao Chongjiang , Xu Xiao , Yuan Biao
Published: November 2024

The formation of glutenin protein corona alleviated gut microbiota dysbiosis, increased the short chain fatty acid production, improved the gut barrier function, mitigated mitochondrial dysfunction, and reduced reactive oxygen species.
Challenges and opportunities in catalytic hydrogenolysis of oxygenated plastics waste: polyesters, polycarbonates, and epoxy resins
Authors: Mitta Harisekhar , Li Lingfeng , Havaei Mohammadhossein , Parida Dambarudhar , Feghali Elias , Elst Kathy , Aerts Annelore , Vanbroekhoven Karolien , Van Geem Kevin M.
Published: November 2024

This review comprehensively explores various homogeneous and heterogeneous catalytic systems for the hydrogenolysis of oxygenated polymeric wastes (OXPs), presenting an adaptable solution to plastic pollution and generating valuable feedstock.
Neoteric solvents for exploratory catalysis: hydrophosphination catalysis with CHEM21 solvents
Authors: Finfer Emma J. , Waterman Rory
Published: November 2024

An analysis of CHEM21 solvent categories reveals that green solvents are viable and often superior to oft-used toxic and hazardous solvents for catalytic hydrophosphination regardless of mechanism, substrate, or catalyst.
Methanol-based thermoelectric conversion device with high power
Authors: Aiba Touya , Yamada Haruka , Moritomo Yutaka
Published: November 2024

A MeOH-based thermoelectric conversion device exhibits high output power W depending on its orientation.
Bulk analysis of columbite ores by LA-ICP-MS: development of reference materials and investigation into matrix effects
Authors: Balachandar Subramaniyan , Zhang Wen , Liu Yongsheng , Hu Zhaochu , Chen Haihong , Luo Tao , He Tao , Zeng Xianli
Published: November 2024

Determination of metal elements in columbite ores is of great importance in understanding the potential economic significance and the origin of deposits.
Terpenes, natural dyes and photochemistry: toward the synthesis of photoactive bio-based materials with biocide properties
Authors: Breloy Louise , Elian Christine , Alphonse Vanessa , Lajnef Sonia , Peyrot Fabienne , Jacquemin Denis , Pascal Simon , Devernois Enguerran , Coradin Thibaud , Abbad Andaloussi Samir , Versace Davy-Louis
Published: November 2024

The thiol–ene photochemistry process, combined with terpenes and natural dyes, yields innovative photostimulable and bio-based materials with antibacterial properties.
Quaternary ammonium-functionalized polysilsesquioxanes for antifogging coating
Authors: Hamada Takashi , Sugimoto Tetsuya , Tanaka Arata , Maeda Tetsuya , Katsura Daiji , Koga Hiroyuki , Ohshita Joji
Published: November 2024

Polysilsesquioxane films containing quaternary ammonium groups were prepared via a sol–gel reaction and quaternization and exhibited high water uptake, scratch resistance, and transparency.
Photothermally-activated suspended aerogel triggers a biphasic interface reaction for high-efficiency and additive-free hydrogen generation
Authors: Zhang Qian , Jiang Bo , Gao Yuming , Li Lin , Tang Dawei
Published: November 2024

An innovative photothermally-activated suspended biphase reaction strategy is developed to achieve highly efficient dehydrogenation of pure formic acid.
Carbon dots: synthesis, sensing mechanisms, and potential applications as promising materials for glucose sensors
Authors: Kayani Kawan F. , Ghafoor Dlzar , Mohammed Sewara J. , Shatery Omer B. A.
Published: November 2024

The study on the synthesis of carbon dots, sensing mechanisms, conditions associated with glucose imbalance, and potential applications as promising materials for glucose sensors.
Correction: Mn-ferrite nanoparticles as promising magnetic tags for radiofrequency inductive detection and quantification in lateral flow assays
Authors: Pilati Vanessa , Salvador María , Fraile Leyre Bei , Marqués-Fernández José Luis , Gomes da Silva Franciscarlos , Fadel Mona , Antón Ricardo López , Morales María del Puerto , Martinez-García José Carlos , Rivas Montserrat
Published: November 2024

Correction for ‘Mn-ferrite nanoparticles as promising magnetic tags for radiofrequency inductive detection and quantification in lateral flow assays’ by Vanessa Pilati et al., Nanoscale Adv., 2024, 6, 4247–4258, https://doi.org/10.1039/D4NA00445K.
Revolutionizing healthcare: inorganic medicinal nanoarchitectonics for advanced theranostics
Authors: Yu Seungjin , Rejinold N. Sanoj , Choi Goeun , Choy Jin-Ho
Published: November 2024

This review explores recent advancements in inorganic medicinal nanoarchitectonics, emphasizing their pivotal role in drug delivery, bioimaging, targeted therapy, diagnostics, and the potential for future innovations in these domains.
Improved dielectric properties of triphasic (NiFe2O4–2LaFeO3)–Ni–PVDF cermet–polymer composite films via magnetic field-assisted solidification
Authors: Anjeline C. Jesica , Lakshminarasimhan N.
Published: November 2024

Innovative integration of magnetically responsive cermet particles in polymer composites showcasing enhanced dielectric performance through the synergistic combination of ceramic, metal, and polymer.
In(OTf)3-catalysed A3-annulation strategy towards the synthesis of pyrazole-tethered quinoline derivatives and assessment of their luminescent properties
Authors: Jamra Rahul , Malakar Chandi C. , Khullar Sadhika , Singh Virender
Published: November 2024

A straightforward and highly-efficient one-pot approach has been devised for the synthesis of novel pyrazole-tethered quinoline derivatives. These fluorphores displayed excellent photophysical properties with a quantum yield of up to 75%.
One-step preparation of amorphous citrate-chelated CoNiFe trimetallic hydroxides for the oxygen evolution reaction
Authors: Zhou Jiaqi , Zhang Yuhong , Yu Tianrui , Feng Mingxin , Wang Tong , Tong Chuangyi , Zhang Zewu , Bao Jiehua , Zhou Yuming
Published: November 2024

Reasonable morphology regulation and electronic structure modulation enhance the oxygen evolution reaction (OER) performance of the catalyst.
Multicolor and sign-invertible circularly polarized luminescence from nonchiral charge-transfer complexes assembled with N-terminal aromatic amino acids
Authors: Lai Liyun , Wang Shunan , Sang Yunxiao , Feng Chen , Liu Min , Wang Fang , Lin Shaoliang , Zhou Quan
Published: November 2024

Multicolor CPL materials with controllable handedness were constructed from nonchiral luminescent charge transfer complexes through co-assembly with chiral N-terminal aromatic amino acids.
G-quadruplex-guided bifunctional platinum complexes induce multiple pyroptosis pathways for antitumor therapy
Authors: Ma Tian-Zhu , Liu Liu-Yi , Zeng You-Liang , Ding Ke , Liu Wenting , Xiong Xushen , Mao Zong-Wan
Published: November 2024

BiPP reduces G4 oncogene mRNA like c-MYC and VEGF, inhibits tumor growth, activates immune pathways, and induces pyroptosis by lowering BIRC7 and increasing cleaved caspase-3 and GSDME-N, forming an highly integrated antitumor immune network.
Critical assessment of the exsolution process in Cu-doped SrTiO3 by a combined spectroscopic approach
Authors: Mariani Pietro , Sun Xiao , Mascotto Simone , Raimondo Luisa , Sassella Adele , Monticelli Damiano , Berretti Enrico , Lavacchi Alessandro , Stredansky Matus , Cepek Cinzia , Mostoni Silvia , Santoro Carlo , Di Credico Barbara , Scotti Roberto , D'Arienzo Massimiliano
Published: November 2024

Insights for an effective evaluation of copper exsolution in Cu-doped SrTiO3 have been obtained by combining classical techniques with EPR.
Recent advances in the photocatalytic cleavage of C–C and C–N bonds associated with amines and their derivatives
Authors: Ni Qibo , Zhou Yan , Chen Lang , Liu Yunkui
Published: November 2024

The recent advances of the visible-light-mediated photocatalytic cleavage of C–C and C–N bonds associated with amines and their derivatives, which featuring mild conditions, unique selectivity, broad substrate scope and green manner, are reviewed.
Ho3Fe5O12 nanoparticles immobilized on FPS for production of a biopolymer from CO2 and limonene epoxide
Authors: Shafiezadeh Fatemeh , Javid Ali , Zhiani Rahele , Allameh Sadegh
Published: November 2024

Ho3Fe5O12@FPS was synthesized for the first time using an advanced and environmentally friendly method. Subsequently, Ho3Fe5O12@FPS was used as a long-lasting and reusable adsorbent for the reaction of carbon dioxide with limonene epoxide.
Facile synthesis of corticiolic acid—a bioactive pharmacophore from natural sources
Authors: Deevi Sunil Kumar , Anilkumar Bhadra , Pinto Priyanka Gladys , Ramani Prasanna , Vishnuprasad Chethala N. , Shanmugaraju Sankarasekaran , Pandurangan Nanjan
Published: November 2024

Fungal strains have inspired us to find the untapped sources of secondary metabolites.
Rapid activation of a solution-processed aluminum oxide gate dielectric through intense pulsed light irradiation
Authors: Oh Yeon-Wha , Kim Hoon , Do Lee-Mi , Baek Kyu-Ha , Kang Il-Suk , Lee Ga-Won , Kang Chan-mo
Published: November 2024

In this study, we report rapid activation of a solution-processed aluminum oxide gate dielectric film to reduce its processing time under ambient atmosphere.
Innovative multi-layered Fe3O4-Gr/carbon/polypyrrole nanofiber composite: “a new frontier in dielectric enhancement and EMI shielding”
Authors: Anwar Ujala , Rafi Muhammad , Noor Naveed A. , Nazir Sadia , Mumtaz Sohail , Moussa Ihab Mohamed
Published: November 2024

This study presents the synthesis and comprehensive characterization of an Fe3O4-Gr/carbon/polypyrrole nanofiber composite, highlighting its morphology, as determined through Field Emission Scanning Electron Microscopy (FE-SEM) analysis.
Ag(i) emitters with ultrafast spin-flip dynamics for high-efficiency electroluminescence
Authors: Ying Ao , Li Nengquan , Chen Xingyu , Xia Jianlong , Yang Chuluo , Gong Shaolong
Published: November 2024

A series of Ag(i) carbene-metal-amide complexes are developed to exhibit ultrashort TADF lifetimes and high radiative rates. The resulting OLED delivers the state-of-the-art performance of 16.2% external quantum efficiency.
Rare-earth element doped NiFe-MOFs as efficient and robust bifunctional electrocatalysts for both alkaline freshwater and seawater splitting
Authors: Yang Jun , Shen Yong , Xian Jiahui , Xiang Runan , Li Guangqin
Published: November 2024

The doping of rare-earth element into NiFe-MOFs regulated the electronic property of active sites and optimized the adsorption energy of reaction intermediates, leading to superior performance for both alkaline freshwater and seawater splitting.
Radiation-assisted electrochemical reduction of CO2 to CO
Authors: Morco Ryan P. , Diaz Luis A. , Ramirez-Corredores Maria Magdalena
Published: November 2024

Ionizing radiation can enhance the yield of carbon monoxide (CO, a versatile intermediate feedstock) produced from the electrochemical reduction of carbon dioxide (CO2).
Fracture and fatigue characteristics of monodomain and polydomain liquid crystal elastomers
Authors: Hu Minyu , Wang Liqian , Wei Zhuxuan , Xiao Rui , Qian Jin
Published: November 2024

The fracture energy and fatigue threshold of polydomain and monodomain liquid crystal elastomers were quantitatively measured and compared.
High entropy spinel oxide (Ni0.2Co0.2Zn0.2Cu0.2Mg0.2)Fe2O4 nanofibers for efficient oxygen evolution reaction
Authors: Zhang Mengyuan , Zhou Xuanyu , Luo Kongliang , Fan Yaning , He Chuandong , Niu Qiang , Zhang Junjun , Zhang Pengfei , Dai Sheng
Published: November 2024

Developing efficient oxygen evolution reaction (OER) catalysts is urgent for the production of clean hydrogen energy.
Investigation of the atomic layer etching mechanism for Al2O3 using hexafluoroacetylacetone and H2 plasma
Authors: Chittock Nicholas J. , Maas Joost F. W. , Tezsevin Ilker , Merkx Marc J. M. , Knoops Harm C. M. , Kessels Wilhelmus M. M. (Erwin) , Mackus Adriaan J. M.
Published: November 2024

Atomic layer etching (ALE) is required to fabricate the complex 3D structures for future integrated circuit scaling.
Ultrastable InP@Al2O3 nanocomposites with UV curable function for application in white LEDs
Authors: Ding Xiaobo , Hu Hailong , Guo Tailiang , Li Fushan
Published: November 2024

This work is mainly focused on the stability issue of InP quantum dots and proposes corresponding solutions to achieve stability that far exceeds that of other related products. And UV was used to repair its fluorescence loss.
Innovative approaches to sustainable wastewater treatment: a comprehensive exploration of conventional and emerging technologies
Authors: Shamshad Jaweria , Ur Rehman Rashid
Published: November 2024

Access to clean water is under threat due to population growth, climate change, and pollution, emphasizing the need for effective wastewater treatment.
Treated wastewater reuse for crop irrigation: a comprehensive health risk assessment
Authors: Ofori Solomon , Di Leto Ylenia , Smrčková Štěpánka , Lopez Marin Marco Antonio , Gallo Giuseppe , Růžičková Iveta , Wanner Jiří
Published: November 2024

The use of treated effluent/wastewater (TWW) for crop irrigation is gaining prominence globally due to growing freshwater scarcity. However, there are still questions about the safety of such a practice.
Transcriptional profiling reveals the role of Candida albicans Rap1 in oxidative stress response
Authors: Wang Wen-Han , Chen Hsuan-Yu , Chen Sheng-Yuan , Lan Chung-Yu
Published: November 2024

Candida albicans is a member of the human commensal microbiota but can also cause opportunistic infections, including life-threatening invasive candidiasis, particularly in immunocompromised patients. One of the important features of C. albicans commensalism and virulence is its ability to adapt to diverse environmental stress conditions within the host. Rap1 is a DNA-binding protein identified in yeasts, protozoa, and mammalian cells, and it plays multiple functions, including telomere regulation. Intriguingly, our previous study showed that Rap1 is also involved in cell wall integrity, biofilm formation, and virulence in C. albicans. In this work, using RNA-seq analysis and other approaches, the role of C. albicans Rap1 in oxidative stress response was further revealed. The RAP1-deletion mutant exhibited greater resistance to the superoxide generator menadione, a lower level of intracellular reactive oxygen species (ROS) upon menadione treatment, and higher expression levels of superoxide dismutase genes, all in response to oxidative stress. Moreover, the association between Rap1-mediated oxidative stress response and the mitogen-activated protein kinase (MAPK) Hog1, the transcription factor Cap1 and the TOR signalling was also determined. Together, these findings expand our understanding of the complex signalling and transcriptional mechanisms regulating stress responses in C. albicans.
The physiological anti-hypertensive peptide catestatin and its common human variant Gly364Ser: differential cardiovascular effects in a rat model of hypertension
Authors: Rathee Jitesh Singh , Iyer Dhanya R. , Kiranmayi Malapaka , Reddy Samarasimha , Sureshbabu V.V. , Mahapatra Nitish R.
Published: November 2024

Catestatin (CST), a 21-amino acids physiological peptide, has emerged as a key modulator of cardiovascular functions due to its anti-hypertensive and cardioprotective properties. However, the ramifications of the most common human variant of CST (viz., Gly364Ser) on cardiovascular pathophysiology remain partially understood. In this study, hypertension was induced in uninephrectomized rats by treatment with deoxycorticosterone-acetate and sodium chloride (DOCA-salt). The DOCA-salt-induced hypertensive (DSHR) animals were then intraperitoneally administered with either CST wild-type (CST-WT) or 364Ser variant (CST-Ser) peptide. CST-Ser was profoundly less effective than CST-WT in rescuing the elevated systolic blood pressure [from ∼211 mmHg to ∼176 mmHg, p < 0.0001 (CST-Ser) versus ∼116 mmHg, p < 0.0001 (CST-WT)] and heart rate [from ∼356 bpm to ∼314 bpm, p = 0.66 (CST-Ser) versus ∼276 bpm, p = 0.02 (CST-WT)]. CST-Ser also showed diminished effects in lowering diastolic blood pressure and mean arterial pressure in the DSHR animals. Furthermore, CST-Ser was inefficient/markedly less potent in rescuing the impaired contractile and diastolic function in DSHR animals [improvements in the contractility index by ∼22 s–1 (CST-Ser), p = 0.15 versus by ∼84 s–1 (CST-WT), p < 0.0001 and decrease in end-diastolic pressure by ∼4 mmHg (CST-Ser), p = 0.015 versus by ∼14 mmHg (CST-WT), p < 0.0001]. Moreover, CST-Ser exerted less potent anti-inflammatory effects on the DSHR hearts than CST-WT. These findings are in concordance with the elevated systolic/diastolic blood pressure observed in Ser variant carriers from various human populations. This study provides compelling evidence for the diminished anti-hypertensive and cardioprotective effects of the CST-Gly364Ser variant.
A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway
Authors: Pauzaite Tekle , Nathan James A.
Published: November 2024

Hypoxia Inducible transcription Factors (HIFs) are central to the metazoan oxygen-sensing response. Under low oxygen conditions (hypoxia), HIFs are stabilised and govern an adaptive transcriptional programme to cope with prolonged oxygen starvation. However, when oxygen is present, HIFs are continuously degraded by the proteasome in a process involving prolyl hydroxylation and subsequent ubiquitination by the Von Hippel Lindau (VHL) E3 ligase. The essential nature of VHL in the HIF response is well established but the role of other enzymes involved in ubiquitination is less clear. Deubiquitinating enzymes (DUBs) counteract ubiquitination and provide an important regulatory aspect to many signalling pathways involving ubiquitination. In this review, we look at the complex network of ubiquitination and deubiquitination in controlling HIF signalling in normal and low oxygen tensions. We discuss the relative importance of DUBs in opposing VHL, and explore roles of DUBs more broadly in hypoxia, in both VHL and HIF independent contexts. We also consider the catalytic and non-catalytic roles of DUBs, and elaborate on the potential benefits and challenges of inhibiting these enzymes for therapeutic use.
A Viewpoint on the Ethics of Pseudostuttering Assignments: Guidelines and Best Practices for Their Use
Authors: Gore Katie , Tichenor Seth E.
Published: November 2024

Purpose:

Pseudostuttering, or the act of voluntarily stuttering or stuttering on purpose, has been both regularly used by clinicians alongside clients in stuttering therapy and taught to students in stuttering courses for decades. However, in recent years, teaching speech-language pathology students how to pseudostutter in stuttering courses has been increasingly questioned by students on grounds that pseudostuttering may be ableist, a disability simulation, and of questionable clinical value. The purpose of this article is to discuss the value and ethics of pseudostuttering assignments as part of graduate clinical education for speech-language pathologists (SLPs).

Method:

The history of pseudostuttering and the pseudostuttering assignment within speech-language pathology pedagogy, disability studies literature, and community perspectives are reviewed. In so doing, we incorporate views from the broader disability rights community, the stuttering community, and stuttering research and clinical literature.

Results:

Stuttering literature and community perspectives not only confirm the value of pseudostuttering assignments but also underscore the critical importance of assignment purpose, framing, structure, and scope.

Conclusions:

Pseudostuttering continues to be a critical clinical skill for SLPs who work with people who stutter, and pseudostuttering assignments are an invaluable learning experience for speech-language pathology graduate students. However, assignments must be designed and implemented according to a specific set of principles and best practices. Assignment design that does not follow these principles and best practices is likely to perpetuate ableist constructs and inadequately prepare students to work with individuals who stutter. Graduate course instructors should educate themselves on these principles and engage with students who express concerns with the assignment.
Microbiome and Communication Disorders: A Tutorial for Clinicians
Authors: Venkatraman Anumitha , Davis Ruth , Tseng Wen-Hsuan , Thibeault Susan L.
Published: November 2024

Purpose:

Emerging research in the field of microbiology has indicated that host–microbiota interactions play a significant role in regulating health and disease. Whereas the gut microbiome has received the most attention, distinct microbiota in other organs (mouth, larynx, and trachea) may undergo microbial shifts that impact disease states. A comprehensive understanding of microbial mechanisms and their role in communication and swallowing deficits may have downstream diagnostic and therapeutic implications.

Method:

A literature review was completed to provide a broad overview of the microbiome, including differentiation of commensal versus pathogenic bacteria; cellular mechanisms by which bacteria interact with human cells; site-specific microbial compositional shifts in certain organs; and available reports of oral, laryngeal, and tracheal microbial dysbiosis in conditions that are associated with communication and swallowing deficits.

Results/Conclusions:

This review article is a valuable tutorial for clinicians, specifically introducing them to the concept of dysbiosis, with potential contributions to communication and swallowing deficits. Future research should delineate the role of specific pathogenic bacteria in disease pathogenesis to identify therapeutic targets.
A novel deep reinforcement learning‐based algorithm for multi‐objective energy‐efficient flow‐shop scheduling
Authors: Liang Peng , Xiao Pengfei , Li Zeya , Luo Min , Zhang Chaoyong
Published: November 2024

A novel algorithm combining bidirectional recurrent neural networks (BiRNNs) with temporal difference is proposed for multi‐objective energy‐efficient non‐permutation flow‐shop scheduling problem (NFSP). The objectives of this problem involve minimising both the makespan and total energy consumption. To begin, a mathematical model is formulated to represent the energy‐efficient NFSP. Subsequently, the NFSP is transformed into a Markov decision process, where an action space comprising 28 scheduling rules is constructed. Considering the global and local features of NFSP, a set of 15 state features is extracted. Different reward functions are then defined to correspond to the specific objectives. Furthermore, the state features of NFSP are extracted using a multi‐layer perceptron model based on BiRNNs. By utilising the TD(λ) algorithm to calculate the state value function, various policies are generated. In order to evaluate the proposed algorithm, a new test set for the energy‐efficient NFSP is constructed, building upon classic benchmark problems. Finally, comparison experiments are conducted to demonstrate the effectiveness and efficiency of the proposed algorithm.
A related convolutional neural network for cancer diagnosis using microRNA data classification
Authors: Jaddi Najmeh Sadat , Abdullah Salwani , Goh Say Leng , Hasan Mohammad Kamrul
Published: November 2024

This paper develops a method for cancer classification from microRNA data using a convolutional neural network (CNN)‐based model optimized by genetic algorithm. The convolutional neural network has performed well in various recognition and perception tasks. This paper contributes to the cancer classification using a union of two CNNs. The method's performance is boosted by the relationship between CNNs and exchanging knowledge between them. Besides, communication between small sizes of CNNs reduces the need for large size CNNs and, consequently, the computational time and memory usage while preserving high accuracy. The method proposed is tested on microRNA dataset containing the genomic information of 8129 patients for 29 different types of cancer with 1046 gene expression. The classification accuracy of the selected genes obtained by the proposed approach is compared with the accuracy of 22 well‐known classifiers on a real‐world dataset. The classification accuracy of each cancer type is also ranked with the results of 77 classifiers reported in previous works. The proposed approach shows accuracy of 100% in 24 out of 29 classes and in seven cases out of 29, the method achieved 100% accuracy that no classifier in other studies has reached. Performance analysis is performed using performance metrics.
CASSC: Context‐aware method for depth guided semantic scene completion
Authors: Cao Jinghao , Li Ming , Liu Sheng , Li Yang , Du Sidan
Published: November 2024

Semantic scene completion is a crucial end‐to‐end 3D perception task, and the 3D information perception subjects is vital for autonomous driving. This paper presents CASSC, a novel adaptive context‐aware method based on Transformer networks, aimed at realizing camera‐based semantic scene completion algorithms. The key idea is to leverage rich context information from images to obtain pixel‐level label proposals, followed by designing a multiscale fusion mechanism to merge this information and match it with voxel space. A weakly supervised training strategy is proposed to obtain semantic label distribution features from images and introduce an adaptive multiscale fusion module to fuse and adaptively match these features with voxel space. Here, CASSC achieves state‐of‐the‐art performance on the SemanticKITTI dataset and demonstrates excellent performance on the SSC‐Bench dataset. Ablation experiments validate the rationality and effectiveness of our design, and the model and code of CASSC will be open‐sourced on https://github.com/dogooooo/CASSC.
Risk‐based maximum speed advisory system for driving safety of connected and automated bus
Authors: Tak Sehyun , Kim Sari , Lee Donghoun
Published: November 2024

Bus rapid transit (BRT) system is a cost‐effective way to provide public transportation service. However, it faces some challenges such as reduced labour productivity and increasing fuel costs. One solution is introducing automated vehicles (AV) to reduce operational expenses. However, there are still limitations on completely replacing human drivers even in limited operational design domains (ODD). Furthermore, AVs often suffer from poor driving stability in some roadways, such as abrupt changes in road geometry. To enhance the driving safety of AV‐based BRT services, this study develops a new connected and automated bus (CAB) system using a cloud‐based traffic management centre with cooperative intelligent transportation systems. The proposed system introduces risk‐based maximum speed advisory system (RMSAS), which controls the maximum advisory speed of CAB to reduce its driving risk. This research evaluates the performance of RMSAS by comparing it to other driving modes, such as human‐driven vehicles and conventional AVs, based on real‐world field operational tests. The result shows that the proposed system outperforms other driving modes in terms of driving risks, particularly in some road geometry‐related ODDs. Hence, this research concludes that the proposed system can be applied to the AV‐based BRT service for uprating its safety performance.
Computation of monostatic RCS using adaptive sparsity pattern preconditioning with an MBF‐MLFMM approach
Authors: Delgado Carlos , García Eliseo , Cátedra Felipe
Published: November 2024

This work presents a numerical technique for the analysis of the Radar Cross Section (RCS) of large targets combining macro‐basis functions, the multilevel fast multipole method and the generation of near‐field preconditioners, using an approximate inverse matrix where the sparsity pattern is dynamic and computed considering an upper memory threshold. In order to improve the scalability, a group of rows is computed using the same least squares matrix minimising the Frobenius norm of the error, rendering each row group problem independent from the rest. This approach is applied to large and realistic problems in the test cases included. The presented preconditioner can be used to optimise the convergence of complex problems with respect to the hardware resources available in each case while being transparent to the user.
Empowering Creative Education: Applying ChatGPT for Enhancing Personalized Learning in Senior Teacher-Driven Instructional Design in the Philippines
Authors: Hatmanto Endro Dwi , Rahmawati Fitria , Pasandalan Sittie Noffaisah B. , Sorohiti Maryam
Published: November 2024

The primary objective of this research is to investigate the impact of ChatGPT on enriching personalized learning in senior teacherled instructional frameworks in the Philippines. through a qualitative approach involving semi-structured interviews with ten senior teachers from Mindanao city, Philippines, this study aims to delve into senior teachers’ perceptions and approaches towards the integration of ChatGPT. The results indicate a generally positive outlook among participants regarding ChatGPT’s capacity to offer customized feedback, adjust to diverse learning preferences, and promote student independence. Despite these benefits, apprehensions were expressed regarding ChatGPT’s cultural awareness, dependability, and the risk of diminishing human interaction. Participants stressed the significance of providing adequate training and assistance to teachers, incorporating ChatGPT into current methodologies, and tailoring it to suit the local educational environment. The strategies identified include personalized learning trajectories, responsive feedback systems, structured learning tasks, student-centered investigations, and reflective metacognition. This research underscores the transformative capacity of ChatGPT in personalized learning, while underscoring the importance of addressing cultural and operational obstacles, thereby presenting valuable insights for educators, policymakers, and stakeholders striving to enhance educational practices in technology-driven societies.
Incorporating Cloud Computing in Accounting Education: A Theoretical Approach for Tertiary Curriculum in Bangladesh
Authors: Lemon Habjul Alam , Jahid Md Abu , Hossain Syed Zabid
Published: November 2024

This study addresses the pressing need to integrate cloud computing and artificial intelligence (AI) into Bangladesh’s tertiary accounting curriculum to keep up with modern information technology in a world where AI and cloud computing are increasing. Notwithstanding the rapid growth of Bangladesh’s economy and ICT sector, a substantial gap persists in incorporating AI and cloud computing into the accounting study curriculum. While these advances enhance efficiency, accessibility, flexibility, and economic viability, they face challenges related to safety, confidentiality, and insufficient investment in emerging technology. This article advocates for reforming the educational curriculum to incorporate emerging technology, hence fostering the development of future reskilled accounting professionals.