bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular designing and Virtual Screening Based Drug design for MABA Enzyme of Mycobacterium Tuberculosis
Authors: Panda Debashis , Chowdhury Abhishek , Laskar Monjur Ahmed , Choudhury Manabendra Dutta
Published: September 2022

Objective: Computer Aided Drug Designing of the NAP binding site of MabA enzymes. Methodology: Mycobacterium tuberculosis causes global infectious disease tuberculosis, which has remained among the top 10 causes of death worldwide. The emerged multidrug-resistant TB (MDR TB) and extensively drug-resistant TB (XDR TB) makes this problem more complex. β-ketoacyl-ACP reductase (MabA), a member of the type-II fatty acid elongation system (FAS-II) is primarily involved in the creation of very long chain fatty acid derivatives. These derivatives are essential precursors for mycolic acids, primary constituents of M. tuberculosis cell wall. Here we have adopted the computational approach followed by ligand molecular modelling, ligand screening, virtual screening and binding pattern analysis in search of potential new lead compounds for Mycobacterium tuberculosis MabA protein. Results: The ligands were screened using an integrated computational protocol that relies on virtual screening and ADMET analysis methods. In this study, we found two compounds, i.e., Compound a1 and a2, which showed the highest binding energy and established the hydrogen bond with the MabA enzyme. Conclusion: Computer Aided Drug Designing approach revealed that two compounds (a1 and a2) had the potential to interact with the NAP binding site of MabA enzymes. Keywords: β-ketoacyl-ACP reductase, MabA, Computer Aided Drug Designing, ADMET
Retrospective Study of Magnetic Resonance Imaging (MRI) Findings in Pott’s Spine
Authors: Wahid Ghazala , Akhtar Sayed Sohail , Kamran Ayesha , Alavi Mehvish Zahra , Haider Nadia , Musammar Maria
Published: September 2022

Tuberculosis is the very communal infection found globally and can nearly all parts of the human body can be affected by it, mostly affect the chest. Among the tuberculosis of the skeletal system; 50% of cases affect the spinal cord. Tuberculosis infection of the spinal cord results in Gibbus deformity, edema, involvement of intervertebral discs, epidural abscess, paravertebral abscess and edema with bone destruction and vertebrae collapse in the soft tissue planes. The most valuable diagnostic tool is MRI as it can clearly show all of the above results in the spine tuberculosis affected patients. Aim: The objective of this research was to know the pattern of incidence and to analyzed the several Pott’s spine pathological processes by means of the MRI scan. Study Design: A Retrospective study. Place and Duration: In the Radiology Department of HMC Peshawar and Orthopedic Department of BKMC Swabi from August 2021 to January 2022. Methods: This study analyzed MRI scans of 90 identified patients of spinal tuberculosis performed at the Radiology Department to govern the pattern of the several pathological lesions. Results: This study institute Pott's spine to be more common in the 21-50 age group, mostly among men. The lumbar and dorsal vertebrae are often affected and several vertebrae are affected frequently, with the most common affected is the L3 vertebra. The involvement of Intervertebral disc and para and pre-vertebral collections were communal, with epidural collection happening in > 75 of patients. 13.3% of the patients have cord oedema. Conclusions: MRI is very sensitive in detecting various Potts spine pathological processes, and the occurrence patterns of these findings were assessed in this research. As the prevalence and incidence of tuberculosis depends on several sensitive epidemiologically parameters, this research could deliver a standard conclusion against which further results could be compared in future studies. Keywords: Tuberculous spondylitis, lumbar abscess, Gibbus
Neoadjuvant Docetaxel Plus Carboplatin Versus Epirubicin Plus Cyclophosphamide Followed by Docetaxel in Triple-Negative, Early-Stage Breast Cancer
Authors: Anwer Rana Atique , Ghafor Sajid , Ahmad Huma
Published: September 2022

Objective: To evaluate the safety and efficacy of epirubicin and cyclophosphamide followed by docetaxel versus docetaxel and carboplatin chemotherapy in triple-negative, early-stage breast cancer (TNBC). Methodology: A prospective study was conducted in the oncology ward of Nishtar Hospital, Multan, from 3rd Mar 2021 to 3rd Mar 2022. A total of 70 TNBC women were included in the study and were divided into two groups. Group DC (35 patients) was administered docetaxel plus carboplatin and then underwent a mastectomy. Group ECD (35 patients) was administered epirubicin plus cyclophosphamide followed by docetaxel underwent mastectomy. Both groups received radiotherapy after mastectomy. Results: In group A, 21 patients (60.0%) achieved a pCR (95% CI 46.0-74.3), 13 patients (38.1%) achieved a pCR (95% CI 23.1-52.0). The difference between both groups was 21.9% (OR 2.49, 95% CI 2.2-42.5; p=0.002); hence non-inferiority was met. DCb regimen showed improved results compared to the EC-D regimen (p=0.039). After 1-year follow-up, it was observed that overall survival and event-free rates did not differ significantly between both groups. Conclusion: Docetaxel along with carboplatin demonstrated higher pCR than that of anthracycline and taxane-based treatment regimens. However, no significant difference was found between the two in terms of overall survival and event-free survival. Surprisingly, docetaxel and carboplatin caused a higher incidence of treatment-associated adverse effects. Keywords: Chemotherapy, radiotherapy, mastectomy, triple-negative breast carcinoma.
Differentiating Pyogenic Brain Abscesses and Tuberculous using Magnetization Transfer MR Imaging and in Vivo Proton MR Spectroscopy
Authors: Islam Zia Ul , Nighat Sumera , Firdous Atqa , Saqib Hammad Ahmad , Majeed Umaima , Zahra Mahwish
Published: September 2022

Objective: To find whether in vivo proton MR spectroscopy and magnetization transfer (MT) MR imaging can be used to differentiate between tuberculous brain abscess and pyogenic brain abscess. Study Design: Retrospective Place and duration: Radiology Department of Ibn_e_Sina Hospital Multan from January 2021 to January 2022. Methodology: The study included 15 subjects with brain abscesses who underwent in vivo MR spectroscopy, MT MR imaging and conventional MR imaging. Those with other systemic diseases were excluded. These techniques were also performed on 10 sex and age-matched control subjects for comparing MT ratios in normal and diseased parenchymal locations. 13 tuberculous abscesses were found in 4 patients, and 20 pyogenic abscesses were found in 11 patients. MT MR imaging and in vivo MR spectroscopy were used to evaluate suspected brain abscesses. Results: The mean MT ratio of the pyogenic brain abscesses was 25.55±1.60.MR spectroscopy showed that in pyogenic abscesses level of amino acids (valine, isoleucine, leucine) was 0.8 ppm and lipid and lactate was 1.2 ppm. Additionally, acetate, 1.91 ppm; glycine, 3.55 ppm; succinate,2.40 ppm and alanine, 1.47 pm were also seen. Four patients had 13 tuberculous abscesses. The mean MT ratio obtained from tuberculous abscesses was 19.87±1.54, which was significantly lower compared to the cortical grey matter, deep grey matter, white matter and pyogenic abscess (p<.001). Conclusion: MT ratios in tuberculous brain abscesses were lower than in pyogenic abscesses. In vivo, MR spectroscopy in pyogenic abscesses did not show amino acids. Tuberculous brain abscess can be differentiated from the pyogenic abscess by using both in vivo MR spectroscopy and MT MR imaging. Keywords: Pyogenic brain abscess, tuberculous brain abscess, MR spectroscopy
Assessment of Youth Leaders' Physical Activity Levels
Authors: Öner Salih , Boztaş Ahmet Vahit
Published: September 2022

Aim: The purpose of this study is to investigate the levels of physical activity among youth leaders working in Turkey's Eastern Anatolia region. Methods: The purpose of this study is to examine the levels of physical activity among youth leaders operating in the Eastern United States. The study's field includes 111 boys and 60 girls, for a total of 171 young leaders operating in the Eastern Anatolia Region. The sample includes 79 men and 49 women, for a total of 128 youth leaders in these provinces. The study rely on the short form of the International Physical Activity Questionnaire (IPAQ). The data is analyzed using mean and standard deviation analysis techniques, with the Mann-Witney-U and Kruskal Wallis test used to evaluate differences. The results is statistically significant at p < 0.05. Results: According to the obtained results, the Physical Activity (FA) levels of the youth leaders are 1742.3±11.81.0 MET-min/wk, 20.3% inactive, 21.9% minimally active, 57.8% in terms of FA categoryIt is discovered to belong to the category of extremely active. Women have higher levels of physical activity than men, with a statistically significant difference (p<0.05). At the FA level according to the provinces, Erzurum province is seen as very active and Elazig province is in the inactive category. Conclusion: As a result, it is determined that women are better than men in the FA levels of youth leaders by gender. For the provinces that are inactive in the distribution of youth leaders' FA levels by provinces, programs to improve physical activity for youth leaders are also; it can be said that the quality of life can be increased by explaining the importance of physical activity through seminars and symposiums. Keywords: Physical activity, anatolia, sports, youth leader.
Investigation of Digital Game Addiction and Attitudes Towards Sports in Adolescent Individuals
Authors: Yamaner Yusuf Burak , Sarikan Ümran
Published: September 2022

Aim: This study aimed to examine digital game addiction and attitudes towards sports in adolescents. Method: The screening model was used in our research. After giving preliminary information about the questionnaire to the participants, a total of 191 volunteers, 113 (59.5%) females and 77 (40.5%) males participated in the study voluntarily. In the research, the 'Digital Game Addiction Scale (DGAS-7) and the 'Sports Attitude Scale ' (5-point Likert Type) consisting of 22 items were used as data collection tools. The research data were analyzed with the SPSS 22.0 package program and the margin of error was taken as p<0.05. Results: When the results were examined, it was seen that 59.5% of the participants were women, 40.5% were men, and 45.8% participated in the exercise activity. At the same time, it was understood that the total scores of psychosocial development, mental development and attitude towards sports, which were sub-dimensions of the sports attitude scale, of the participants who exercise had higher scores than the participants who did not exercise. In this context, it can be said that the attitudes of the participants who exercise were more meaningful. Conclusion: As a result, young adult individuals who were connected to games may have difficulties in fulfilling their daily responsibilities and may cause mental and cognitive disorders as a result of establishing a connection between real life and the virtual world, which can negatively affect their academic achievement levels. Moreover, individuals should be encouraged to participate in sports, because it was thought to have a positive effect on the mental and physical development of young adults. Keywords: Adolescent, Sports and Digital Game This Research Was Present at as Oral Presentation the 8th International Congress on Science, Culture and Sports
Diversity of Uropathogens and their Antibiotic Susceptibility Pattern
Authors: Mahmood Fawad , Mohammad Sajjad , Kousar Khalida , Ullah Ikram , Ahmad Burhan , Khan Zahid Ullah
Published: September 2022

Bacterial urinary tract infection (UTI) is one of the utmost prevailing bacterial diseases that affect both sexes at different ages. Due to emerging multi-drug resistant (MDR) bacteria, it is necessary to investigate the antibiotic susceptibility pattern of the bacterial agents to improve the empirical treatment. In this study, we collected a total of 142 urine samples from infected individuals of both sexes at Al-khidmat diagnostics and blood bank from January to March 2022. Different antibiotic susceptibility patterns of the bacterial isolates were examined by using the disk diffusion method. The UTI was reported in 21 (15 %) males and 119 (85 %) females. the highest number of positive individuals are found in middle and old age groups respectively 40 % and 44 %. While 96 % of uropathogens are gram-positive and only 3 % of cases were caused by gram-negative bacteria. The most prevalent pathogen was E.coli 62 % and followed by Staphylococcus Aureus 12 %.In study showed that E.coli is 62 % amoxicillin, Cefuroxime 23, Cefixime 48 %, Norfloxacin 24, Penicillins 37 % , Ciprofloxacin 24 %, Gentamycin 8 %, Ceftriaxone 20 %, and Levofloxacin 4 % resistant. The current study concluded that antibiotic resistance among urinary pathogens was raised, and significant variance in antibiotic susceptibility patterns was identified. UTIs can be treated with medicines such as Levofloxacin, Gentamycin, Teicoplanin, and Moxifloxacin. This study's findings indicate that future research should focus on the causes of resistance to identify solutions to this crucial problem, as well as on the use of health education to prevent drug usage. Keywords: Uropathogens, Antibiotics, Urinary tract infection, UTI, MDR
Knowledge, Attitude and Practice of Epileptic Patients Towards Their Disease
Authors: Fatima Syeda Shumaila , Shah Shahnaz , . Jaysingh , Shaikh Abu Bakar , Majeed Sameena , Ali Muhammad Munwar
Published: September 2022

Introduction: Epilepsy is a persistent brain condition. Patients with this condition experience repeated seizures that are brought on by unexpected, abrupt, and excessive electrical discharges in the brain cells. Numerous morbidities, including death and lowered quality of life, are linked to epilepsy (QoL). The development of the proper attitude toward the disease was aided by epilepsy sufferers' awareness of their condition. Objective: To determine the frequency of adequate knowledge of patients who present with epilepsy at neurology ward of tertiary care hospital in Karachi. The design of this study was descriptive cross-sectional study. This study was conducted at Jinnah Postgraduate Medical Centre, Karachi and the duration of this study six months and was from January 2021 to June 2021. A total of 91 diagnosed case of epilepsy were included in this study. The researcher was collected data on a prescribed questionnaire regarding demographic variables like age, gender, education level, profession, monthly family income, address & duration of disease. All questions to measure the knowledge, attitude & practices were closed ended with the answer ending in fixed options (Yes/ No). Each correct answer was given score 01and summed up. Results: The mean age of the patients was 43.08±10.88 years. There were 42(46015%) male and 49(53.85%) female. Frequency adequate knowledge of patients who present with epilepsy was observed in 24.18% (22/91) cases. Conclusion: The patients in our research had a rudimentary awareness of epilepsy, but they had little information about safety precautions, social concerns, or available treatments. In order to enhance AKA for epileptic patients and their families, an improved public epilepsy education paradigm, such as an IT-based epilepsy education tool, is certainly required given the existing level of patient knowledge of the condition. These knowledge gaps between the patient and caregiver might be identified by medical specialists like doctors and clinical pharmacists. Keywords: Epilepsy, Neurology, Quality Of life, Chronic Brain Disorder
25-Hydroxycholecalciferol Response to Single Oral Cholecalciferol Loading in the Normal Weight, Overweight, and Obese
Authors: Ali Ambreen , Abid Fatima , Islam Asif , Gul Sara
Published: September 2022

Objective: The aim of the study is to evaluate the response of 25- hydroxycholecalciferol (25OHD) to a single oral administration of cholecalciferol in the normal weight, overweight, and obese individuals. Place and duration of study: The study is conducted in Pak International medical College Hayatabad and the duration of study was from March 2021 to March 2022 Material and Method: We have examined 60 healthy women from the age groups of 24-68 years(mean+ SD, 51.2+ 9.6) with a body mass index in kg/m2 ranging from19.2 to 43.2 (mean + SD 28.2+5.9). Female individuals are divided into 3 groups based on their body mass index, 1st group is having normal female individuals having BMI less than 25 kg/m2 (n=22), 2nd group having BMI of 25.1-29.9 kg/m2(n=23)and 3rd group having BMI greater than 30Kg/m2(n=15). Every participants is taken a single oral dose of cholecalciferol(300,000 IU) and their Venous blood samples are taken to measure the concentration levels of 25OHD, 1,25(OH)2D, parathyroid levels, calcium and phosphorus levels. The results are categorized in the form of mean, standard deviation, p-values, least square means with 95% confidence intervals (CI) in each group of individuals at 8th and 31st days of cholecalciferol administration. Results: The total body fat of normal weight group is significantly lesser than that overweight group of individuals, which is lesser than that of group of obese individuals. At the beseline detection of serum level of 25 OHD all the women have detectable serum levels of 25OHD. In the obese group of individuals there will be a lesser levels of 25 OHD observed than normal group of individuals and the difference is approximately equal in the case of overweight group of individuals. The obese group of individuals also have approximately lesser levels of 1,25(OH)2D than the normal group of individuals but have increasing levels of parathyroid hormones. After administration of cholecalferol the levels of parathyroid hormone is observed significantly lesser at day 8 than baseline in the normal weight of individuals not in other groups, which approximately increasing over time at day 31 in all the groups of individuals. There is a positive correlation found between the concentrations of 25OHD and 1, 25(OH)2D while there is a negative correlation found between the levels of 25 OHD and parathyroid hormone at all time points. Conclusion: Serum levels of 25 OHD become decreases in obese individuals is due to their increase body volume. The levels of decline of 25 OHD in obese is due to their larger body size and slower release of vitamin D from their body fat. Keywords: Adipose tissues, Obesity, Vitamin D, Cholecalciferol, Overweight, Calcium.
Factors influencing generation of domestic solid wastes in Kisii Town, Kenya
Authors: Naftal Omonywa Mecheo
Published: September 2022

Domestic solid waste management (DSW) has been a critical problem in many urban centres in developing countries, including in middle sized towns. This paper investigates the factors influencing the generation of domestic solid waste in residential estates of Kisii town. The specific objective of the study included: to investigate the factors influencing the generation of DSW in residential estates in Kisii town. A mixed methodology approach was taken into consideration. A data sample of 110 households was obtained using the multi stage stratified sampling method from a target population of 20,000 households. Data collection methods of the sampled size involved the use of questionnaires to the householders and direct interviews to county officers in charge of DSW and observation integrated with photography. Data analysis was carried out using methods such as use of tables, use of graphs through SPSS, and other descriptive statistics such as the use of the measures of central tendency were taken into consideration. The results found that various factors including the size of the family 83.7% and the level of income 9.7% influenced the generation of domestic solid waste in the residential areas. In conclusion various factors influence the generation of DSW and the major one is family size. It is therefore recommended that, residents should be sensitized to purchase and cook what they can consume to reduce the excesses which surmount to DSW especially food remains.
Bizmut Tabanlı Bazı Alaşımların Radyasyon Zırhlama Kapasitelerinin İncelenmesi
Authors: YILMAZ Meryem , ERKOYUNCU İlhami , ÖZDEMİR Hatice Gürel , DEMİRKOL İskender , KAÇAL Mustafa Recep , AKMAN Ferdi
Published: September 2022

Sunulan çalışmada, 0.060 MeV ila 2.614 MeV foton enerjileri aralığında 18 farklı enerjide bizmut tabanlı bazı alaşımların gama radyasyonu zırhlama kapasiteleri incelenmiştir. Farklı oranlarda bizmut içeren Bi50/Pb25/Cd12.5/Sn12.5, Bi50/Pb28/Sn22, Bi55.5/Pb44.5, Bi58/Sn42 alaşımlarının gama radyasyonu azaltma kapasiteleri belirtilen enerjilerde WinXCOM programı, GEANT4 ve FLUKA simülasyon programları yardımı ile incelenmiştir. Gama radyasyonu zırhlama özelliklerini incelemek için BiPbCdSn, BiPbSn, BiPb ve BiSn olarak kodlanan alaşımların kütle ve lineer azaltma katsayıları, yarı ve onda-bir kalınlık değerleri, ortalama serbest yolları ve etkin atom numaraları parametreleri belirtilen enerji aralığında hesaplanmıştır. µ/ρ değerlerinin düşük enerjilerde daha yüksek olduğu görülmüştür ve WinXCOM’a göre BiPbCdSn, BiPbSn, BiPb ve BiSn için 0.060 MeV enerjideki µ/ρ değerleri sırasıyla 5.4663, 5.4392, 5.1380 ve 5.7924 şeklindedir. BiPb kodlu alaşımın çalışılan diğer alaşımlara göre gama radyasyonu zırhlama kapasitesinin daha iyi olduğu gözlemlenmiştir.
Levels of Writing Mistakes and its treatment in the light of Modern Approaches(Students of Faculty of Arabic of IIU as Model)
Authors: Ahmad Dr. Zaheer , Ahmad Dr. Akhlaq
Published: September 2022

Writing skills one of the important skills while learning any language. Arabic Writing skill has multi dimensions rules should have to be followed. This analytical research is about to gather samples of writing scripts and its classification according to the types of mistakes and ratio of these mistakes among male and female students comparatively in general. In the second step of these analysis the same mistakes are compared with Pakistani and Chinese students of the faculty. It is significantly observed that Pakistani students commit less writing mistakes in comparison with Chinese students. The main reason lies that Urdu is written in Arabic script whereas Chinese script is totally different in writing script. This research will help out the teachers how to address this problem and they can guide their students to minimize these mistakes.
The Rhetorical and Thematic Methodology of Sheikh ‘Abdul Hayy al-Fārūqī in His Both Exegeses “Tafsīr al-Furqān fī M‘ārif al-Qurān” and “Dars-e Qurān”: A Comparative Study
Authors: Abbas Kaleem , Nadeem Dr. Muhammad Tayyeb , Chishty Dr. Ahsanullah
Published: September 2022

Sheikh ‘Abd al-Hayy al-Farūqī (1887-1965) was the Indo-Pak Sub-continental scholar who became famous in the scientific circles and adhered to the Sheikh of India Mahmood al-Hassan al-Deobandī and extracted the knowledge from his approach. Al-Fārūqī was among the most prominent students of Sheikh ‘Ubaidullāh al-Sindhī and Sheikh Abu al-Kalam Azad. Sheikh ‘Abdul Hayy al-Fārūqi made tremendous efforts in the liberation of the Indian subcontinent from the British rule. After completing the interpretation of the Noble Qur’an under the supervision of ‘Ubaidullāh Sindhī Al-Sindhi in the light of methodology and style of Imām Shāh Walī Allāh, he began to spread it through the teaching and the academic writings. Consequently, he wrote two Tafāsīr known as “Tafsir al-Furqan fi Ma’arif al-Qur’an” and “Dars-e Qurān”, both are in Urdu language and widely published and the first one contains two volumes and it is written for the scholars while the other one is in seven volumes where the scholar made focus on the general masses so that they can understand the true spirit of Qurān easily. This comparative study is to explore the significant features of the both exegeses which are not dealt (as per our knowledge) in an academic manner for the scholars as well for the masses.
The issue of spelling errors in the books of Atraf ul Hadith Study of the book "al'afrad Walgharayib" By Imam Al-Daraqutni as a model
Authors: Ahmed Altaf , Sahibdad Dr. Mufti Muhammad , Ahmed Sajjad
Published: September 2022

Arabic language is a very sensitive in a sense that a change in a letter or Harkat( Fath, Zamma and Kasra) can cause a huge difference in the meaning. If such errors occur in books of Atraf, it can cause multiple difficulties in reaching the exact Hadith. The book Al Garaib wal Afraad is no exception. There are many spelling mistakes in this book and there can be many reasons of it. The book consists of 6400 Afrad Ahadith; I have just conducted research from Musnad Muaaz Bin Jabl, Hadith number 4284 to 4592 around 308 Ahadith. From these Ahadith, I encountered 18 such Ahadith where such errors can be found. This research paper contains an introduction, three chapters and the conclusion. The first chapter deals with a short introduction of the book Al Garaib wal Afraad; while the second chapter presents a brief introduction of life of Imam Dar Qutni. The third chapter presents examples of spelling errors from the book. In conclusion, outcomes of the research have been provided. The research is a descriptive and empirical in its nature as it will give evidences from the book
A Social Obligation of Parents Regrading the Upbringing of their Offspring: An Islamic Perspective
Authors: Gul Dr. Rais , Azizullah Dr. Muhammad , Muhammad Dr. Badshah
Published: September 2022

This article is an attempt to analyze the proper attitude of parents towards their offspring in the light of the Holy Quran and Ahadees (Traditions of the Holy Prophet). The translation of the verses and their interpretations are mainly taken from the well-known commentary books on the Holy Quran, such as,Tafseer-Ibn-Khateer (English version), Tafheem-ul-Quran, entitled, ‘Towards Understanding the Quran’ (English version) by Syed Abul A’la  Maududi, and The Meaning of the Holy Quran with Explanatory Notes by Mufti Taqi Usmani. A fair approach and treatment towards offspring by the parents is one of their main social responsibilities/obligations that would turn the new generation into assets rather than liabilities.This study shows that every sane person begins to aspire for offspring the moment they have tied the knot.  The Muslims should have a firm belief that, like all other matters in life, Allah’s will prevails in the matter of offspring as well. Therefore, the believers should always seek Allah’s help in the matter of offspring and their being on the right track, and should make wholehearted supplications to the Almighty in this regard. The parents should adopt an Islamic outlook and treat their male and female children alike. In the light of the Quranic injunctions, it is crystal clear that offspring are beauty as well as test for parents in their temporal life. Their upbringing, according to the tenets of Islam, would turn them into a soothing balm for the parents not only in this world but would benefit their parents even after their death and on the Day of Judgment as well. It would transform the children into positive and productive human beings for the world around them
Intellectual review of “Shahar-e-Madina Aisa Hai” by Hafiz Muhammad Hussain Hafiz
Authors: Iqbal Saima , Yasmeen Rubina , Afzal Aneesa
Published: September 2022

Hafiz Muhammad Hussain Hafiz(1993-2010) is from Faisalabad,Pakistan. He is very successful Punjabi poet.At the public level ,his Natya Kalam is still read with great relish.He used to write in Urdu from time to time. God-given ability and extensive personal study, as well as the lifelong companionship of scholars, his thoughts and writings produce many virtues.Naat  is fact a statement of the attributes of the Holy Prophet (PBUH). The Holy prophet is beloved of Allah and His creatures. He is the cause of the creation of the universe and the mercy of the worlds. His example of beauty is the best example for all believers.Hafiz Muhammad Hussain, s book “Shahar-e-Madina Asia Hai” in his naat has mentioned the caste, attributes and virtues of the Holy Prophet in a beautiful way.If his Naats are carefully studied,then the first of all his theory of Naat comes to the fore.His two Naatiya books “ Sarkar ki Gali Main” and “ Shahar –e- Madina Aisa Hai” are in Urdu. In this article an intellectual review of his Natya book “ Shahar Madina Aisa Hai” has presented.
Contribution of the Sindhi Scholars to the Hadith Sciences: A Study of Mawlana Abdur Rasheed Numani
Authors: (Zuberi) Muhammad Ahmad , Chisht Prof. Dr. Ali Asghar
Published: September 2022

Contribution of the Sindi Ulama towards Hadith sciences is obvious from the great literature they produced over the last few centuries. There are several studies which deal with this aspect. The current paper is an extension in this regard. The author has focused Mawlana Abdur Rasheed Numani’s contribution to the discipline of hadith. Though Mawlana Numani was a great scholar of Islamic sciences, he had extensively written on the various methodological aspects of hadith sciences and tried his best to respond to some of the long-standing and difficult questions in this regard.
Scientific and Research Review of Eloquence of Quran e Hakeem
Authors: Zahidi Balyalvi Mufti Zaheer Abbas
Published: September 2022

The  Holy  Quran  which was revealed in Arabic language, it’s verses have been explained with help  of  Ahadith and  Aasar  as  well as  Quran itself. The Holy Quran‘s basic understanding is based on comprehension of Arabic language. The eloquence of the Holy Quran is a great miracle. Which has dazzled the people of the language and this understanding is a key to the Holy Quran that is why this title has been designed for research. The Arabs possessed  a remarkable  memory and were an eloquent people. Their eloquence and memory found expression in their poetry and literature. It is no small wonder that  Allah choose the Arabic language for his final dispensation and preservation of his word. The Arabs were impressed by the eloquence of Holy Quran. The eloquence of the Holy Quran dazzled the Arabs poets and it’s litterateur. Verse 90 of Surah An-Nahl is one of the verses therefore astonished the Arabs with its eloquence. This verse is a perfect example of eloquence. its words are short and meanings are wide. After that Walid bin Mughira was convinced and believed that thase are wat words and Usman bin Mazoon said: The eloquence of this verse gave me light of faith, verse 90 of surah an-nahl  also guides us to eradicate all social evils and create an ideal society.
Problems faced by Pakistani Muslim women in peace and reform and their solution in the light of Islamic teachings
Authors: Khan Dr. Muhammad Majid , Hassan Dr. Muhammad Zubair , Haq Dr. Inam ul
Published: September 2022

Human's life cycle began with a man and a woman. The women breed the human race with her blood and children's care, home management, preparation of food and clothes have been remained in her duties. Peace is the substitute of security and reformation is the name of correction. So, it must be in view that where Islam wants collective reform, it never ignores person's correction but it declares that man's correction is truly a social reform. No doubt, the feminist part is called a spinal cord of society, if they come forward in this field to improve the work of reform, unite each other with the concept of every correction, the destination of our society will be reversed. In reality, the society will become a practical model of peace then it can be called a reformed and welfare community. This article will highlight, the problems related to Muslim women in peace and reform in Pakistan with their solutions in the light of Quran and Sunnah.
A Comparative Study of the Four Imams and Imam Ibn e Hazm on Qiyas
Authors: Ahmad Zishan , Muqadusullah Dr.
Published: September 2022

Islam is a comprehensive and complete code of life, all issues of life are in the grip of its teachings, and however the rules of Islam are of two kinds. Specified ((منصوص: The clear solution of which is contained in the Book of Allah and the Sunnah of the Prophet. Unspecified (غیر منصوص): The clear solution of which is not found in the Book of Allah and the Sunnah of the Prophet. That is, an issue which is not explicitly mentioned in the Book of Allah and the Sunnah of the Prophet (peace and blessings of Allah be upon him) and no consensus has been reached in this regard. Qiyas is one of the most important and basic sources of Shari'ah. The Holy Prophet (PBUH) and his Companions used to deduce the rules through Qiyas.  Except for the Ahl al-Zawahir and some Mu'tazilites, no one has denied the validity of the Qiyas. The four Imams count Qiyas among the sources of Shari'ah. They prove the validity of Qiyas by testifying from the Book of Allah and the Sunnah of the Prophet and the sayings of the Companions. While Allama Ibn Hazm has denied the Qiyas. Imam Ibn Hazm has strongly expressed his position on the invalidation of Qiyas. He says that it is not permissible in religion to take Qiyas from speculation and opinion.    In the event of a dispute, Allah has commanded that the matter be referred to the Book of Allah and the Messenger of Allah (peace and blessings of Allah be upon him). Now, whoever returns the disputed matter to speculation or opinion, he has violated the command of God, which is a condition of Iman. Qiyas is a name about which Allah Almighty has not given any permission and has not revealed any evidence in this regard. Undoubtedly, Qiyas is just a guess. What Allah has commanded is obligatory and what He has forbidden is haram. What He has neither commanded nor forbidden is permissible and lawful. There is no need for Qiyas or opinion on anything now. He who made obligatory the thing for which the text was not obligatory or declared the thing which is not haram as haram, then he invented a new law in the religion which was not commanded by Allah.
The Role of Jamia Rizvia Faisalabad in Contribution of Islamic Teachings
Authors: Muhammad Faqir , Ahmed Professor Dr. Matloob , Shahzad Dr. Jameel Ahmad
Published: September 2022

JamiaRizvia “Mezher-ul-Islam” is located in Jhang Bazar Faisalabad. This great Islamic Institute was founded by HazratAllamaSardar Ahmad Chishti Qadri who was great Islamic Scholar, Researcher and Learned personality in the discipline of Quran, Hadith, Islamic Jurisprudence and Arabic Language.TheJamiaRizvia has produced many Ulamas, Orators, Debaters and Authorswhich are serving as Islamic Preachers, CivilGovernmental servants in different official Institution. This Islamic Institute is not only delivering the Islamic and Arabic studies but also current educational courses like as: English, Urdu, Mathematics, Sociology, and Computer Science Pak Studies. So, it can be said that the scholar qualified from this Institution has full command over the Islamic and Modern knowledges. Dueto great effective and appreciable way of Teaching, the last degree of Dars-i- Nizami(Al.Shahadat-ul-Alimyya)is considered equivalent to M.A Islamiat and Arabic.
Shari’ah ruling on removing facial hair and making Eyebrows in the light of Laein Allah Al-Namisa Wal-Mutanamisa, Research Revie
Authors: Rauf Salma , Barvi Dr. Muhammad Mehrban
Published: September 2022

This research paper discusses the subject of eyebrow making and its Shariah rules. The topic was chosen because this fashion is becoming very popular among the people nowadays. And in this matter, there has been a dispute among the Shari’ah scholars in every era from different perspectives. The study sought to uncover the truth and seek the view and opinions of scholars. First of all, it is better to avoid these things, but if it is impossible to avoid them, then at least avoid the ways that are forbidden by Islamic law and which cause the destruction of society. This research discusses the authentic hadiths about “Nams”, the literal and figurative meanings of “Naamisa” and “Mutanamisa”, the reasons for raising eyebrows in the modern age and their modern method. The approaches of previous and present scholars were presented and discussed. In the end, the gist and summary of all these things is given.
Islamic doctrine of selection and appointment: A research Analysis
Authors: Khan Dr. Javed , Haqqani Hafiz Fazle Haq , Bilal Dr. Qaisar
Published: September 2022

Responsibility is a necessary element and integral part of life. Everybody has unique role toward society and is subject to do best for that. There are many tasks and challenges to be performed professionally and dealt with well manner. In present day the society faces many problems socially, politically and economically because social evils like injustice, corruption and robbery are overwhelming everywhere. Due to neglecting the basic merit in selection process, ineligible peoples can’t meet the needs of society as well as the affected people turn toward evils as thieving, looting and terrorism which destroy the peace of society consequently. Therefore, it is mandatory to be followed the eligibility criteria in selection. It will help to abide by the commandments of Al-mighty Allah on one side, and eliminate the injustice from society on the other side. It is moral obligation of higher authorities to appoint suitable and deserve person for each post to make the society peaceful and prosperous. The present paper discusses the basic characteristics and qualities for rulers and leaders specially, and for each post holder generally in Islamic perspective. If the criteria are adopted across the board, many social crises and problems would be tackled automatically and resolved easily. The society will be able to eliminate the evils, to serve the humanity in achieving the well-being and objectives of life.
The Esoteric interpretations of ‘‘Seeing God and Beholding Him: A Special Study of Tafsir Qadiri”
Authors: Mujahid Abdul Haq , -ur-Rehman Prof Dr. Ghulam Shams
Published: September 2022

The Holy Quran contains two types of verses: Muhkamat (sound, clear and evident) and Mutashabihat (not illustrative, vague and difficult to ascertain the exact meaning due to their uncertain interpretation and doubts involved therein). The interpretation of the first category is straightforward while the second is doubtful and uncertain. Therefore, it has been observed that a controversy always exists on the interpretation of these versus amongst theologians. The Divine attributes and Seeing God by humankind in this world are few of those matters which remained under the discussion of Muslim theologians. The question is whether the divine scripture can be explained by reason or not? Most of the traditionalists opine that the interpretation of these ambiguous verses are proscribed. The Ashari theologians are of the view that the Mutashabihat can be interpreted only symbolically while the exact interpretation is beyond the capacity of human beings and the matter of interpretation must be entrusted to God. The interpretation of the attributes of God- the Most High- and the reality of seeing Him is not possible. The intended meaning and original interpretation of such verses cannot be completely made by human intelligence. God Almighty is the omniscient and omnipotent who cannot be observed directly by His creatures. Then, what is the meaning of the verses which state this theme. What type of seeing is it? What are the feelings in the process of “seeing Him?” From herein starts the discussion, whether seeing God is possible or not? This paper aims to answer this question from Sufi perspective as described in Mulla HusaynKashifi’s Tafsir al-Qadiri. An overview has been given on the subject matter for a better understanding of the perspective. A contrastive study enables us to understand Kashifi’s esoteric and symbolic interpretation of this controversial issue.
Islamic view of modernism and rationalism An intellectual debate
Authors: Raeesi Dr. Sajjad Ali , Parveen Dr. Rashida , Nargis Ms.
Published: September 2022

There is a debate among the scholars that Islam is a complete code of life or it is just a spiritual experience. Mostly Muslims consider Islam to be a complete code of life. To them, it is a universal religion that pervades a person's entire life. In the other hand those who are not convinced of the universality of Islam, consider Islam to be an outdated and irrational system. According to them, Islam has no room for modernity and universality. The majority of Orientalist intellectuals are of the opinion that there is no other option for Islam except to accept Western thinking and Western modernism. However, there are several verses in Qur'an that call for reason and reflection of the universe. The Qur'an also commands reason to conquer the universe through intellect and contemplation. This version of Quran clearly shows that Islam is not against modernism nor opposes to use of reason (Aqal). This article discusses such misunderstandings and examines the arguments for modernity and rationalism in Islam.
Expressão de HER2 em câncer gástrico: uma revisão sistemática
Authors: Rocha Bruno de Faria Melquíades da , Gurtat Laura Block , Boss Matheus , Cervini Ricardo , Dal Pont Gustavo Colombo , Centa Ariana
Published: September 2022

Introdução: o receptor HER2 é capaz de induzir proliferação e transformação celular nos tecidos tumorais. Estudos recentes avaliam o papel da proteína nos tumores gástricos e sua influência sobre a doença. Objetivo: sumarizar os conhecimentos que respondem à pergunta “qual a influência do aumento na expressão do receptor HER2 sobre o prognóstico dos pacientes com câncer gástrico?”. Método: revisão integrativa da literatura utilizando as bases de dados PubMed e Lilacs, com os descritores HER2, ErbB2, prognosis, survival, survival patients, stomach neoplasms, stomach cancers, gastric cancer. Resultados: A base de dados apresentou 249 artigos compatíveis com os filtros de pesquisa. Após pré-seleção e uma seleção mais criteriosa pelos autores, 36 artigos foram incluídos na amostra final. Conclusão: A relação entre HER2 superexpresso e o prognóstico para o câncer gástrico é divergente. Mas, evidenciou-se que, devido a diferentes mecanismos de interação HER2-Tumor, sua expressão no tecido tumoral pode auxiliar na decisão da conduta terapêutica.
Os impactos da pandemia da covid-19 no mercado de trabalho do segmento de confecções varejistas na cidade de Cacoal, estado de Rondônia
Authors: Gonçalves Vânia Nunes , Quintino Simone Marçal , Souza Edney Costa , Gomes Angela de Castro Correia , Azevedo Joareis Fernandes de , Nogueira João Ricardo Marques
Published: September 2022

O artigo tem como objetivo demonstrar uma análise dos principais impactos que a pandemia da COVID-19 causou no segmento de confecções varejistas da cidade de Cacoal, estado de Rondônia, em relação ao mercado de trabalho em oferta. A pesquisa é do tipo exploratória e descritiva, com o método dedutivo e a abordagem qualitativa. Os instrumentos de coleta de dados foram a pesquisa bibliográfica e o formulário estruturado no Google Forms, contendo 23 perguntas abertas e fechadas. A amostra foi composta pelos proprietários e gestores das empresas do segmento de confecções varejistas do município em estudo, selecionados de forma intencional. Foram discutidas informações sobre o nível de desemprego e o avanço do vírus da COVID-19, bem como, as principais medidas governamentais para o enfrentamento do vírus e seus impactos no setor de varejo de confecção, cujos resultados evidenciam que o nível de desemprego na cidade da pesquisa não foi alto, pelo contrário teve mais contratações do que demissões, também foi constatado que as empresas usaram todos os benefícios concedidos pelo governo para manter seus funcionários.
Mimarlıkta Kinetik ve Otomasyon Ara Kesitinde Etkileşimli Sistemleri Tasarım Stüdyosu Üzerinden Deneyimlemek
Authors: ÇAKICI ALP Neşe , ÖNER Dilan
Published: September 2022

Farklı disiplinlerin zaman içinde gelişim göstermesi, disiplinlerin iç içe geçmesini ve kaynaşarak birbirlerini geliştirmelerini sağlamıştır. Mekanik, elektronik ve gömülü hesaplama araştırmalarının mimarlık disiplinine -özellikle de kinetik mimari- izomorfik yakınsaması ile mimarlıkta etkileşimli kinetik sistemler son 10 yılda etkin biçimde kullanılmaya başlanmıştır. Bu bağlamda etkileşimli kinetik mimariyi bir transdisipliner çalışma olarak değerlendirmek mümkündür. Yenilikçi ve özgün mimari çözümlerin üretilmesinde diğer disiplinlere ait sayısal bilgiyi, mimariye tasarıma aktarabilmesinin önemi gün geçtikçe önem kazanmaktadır. Bundan dolayı, mimarlık öğrencilerinin endüstri 4.0 çağında sayısal bilgiyi okuyabilir olmaları ve bunu deneyimlemeleri önemlidir. Bu amaçla çalışma kapsamında, otomasyon teknolojilerinin tasarım stüdyosuna olan entegrasyonu araştırılmıştır. Bu nedenle, farklı disiplinlere ait sayısal bilgiyi kullanabilmek için, mimarlık bölümü 2. sınıf tasarım stüdyosu dersinde, toplam sekiz öğrenci ile, çeşitli aşamalardan oluşan bir eğitim metodolojisi, üç hafta süren transdisipliner ampirik stüdyo çalışması üzerinden deneyimlenmiştir. Tasarım stüdyosu dersinde öğrencilerden, Kocaeli İli İzmit ilçesinde tasarlanacak olan performans sanatları merkezini cephesinde kullanılmak üzere, kinetik bir yüzey tasarlamaları istenmiştir. Bu makalede, 2. Sınıf mimari tasarım stüdyosu kapsamında, kinetik sistemlerin ve gelişen otomasyon sistemlerin mimarlık eğitime dahil edilme metodolojisi ve ortaya çıkan nihai ürünler (prototipler) aktarılmış ve üretilen prototipler belirli kriterler üzerinden değerlendirilmiş ve öğrencilerin, mimari tasarım ve üretim sürecinde diğer disiplinlere ait sayısal bilgiyi kullanabilme kabiliyetleri analiz edilmiştir.
Upregulation of IL-10 and IL-12 upon QX Vaccine in Broilers
Authors: Bzaebz Ahmed Kareem , Al-Ibadi Israa Najm Abdullah , Al-Nailey Khalil Gazar Chelab
Published: September 2022

The present study has been designed to investigate of infectious bronchitis virus (IBV).is a widely distributed poultry disease that has large economic impact on poultry industry. Infections of the respiratory, reproductive, and renal systems are caused by IBV. The avian immune system is capable of activating mucosal, humoral, and cell-mediated immunity in response to future antigen exposure. Currently, live attenuated and killed vaccines are used to control IBV infection; however, the emergence of new IBV variants with rapidly evolving genetic variants raises the risk of outbreaks in intensive poultry farms. The study has been conducted on Two hundred broilers from (Breed: Rose, Origin: Belgium) were brought from ALGhadeer Hatchery–Wasit during the period extended from July, 2021 to March, 2022. The chicks were divided randomly into 4 groups namely 1st,2nd, 3rd, and 4th group. Each group consisted of 50 birds and housed in 4 separated rooms about 200 meters distance far between them. Blood samples (2 ml) collected from jugular vein from 18 chicks selected randomly from each group. T
Evaluation of functional and radiological outcomes of using antiglide plates in vertical medial malleolus fractures
Authors: Jadhao Amit Bansilal , Gupta Anuraag Ghanshyamdas , Janorkar Prashant Shivanand , Adhikari Archit Ajit
Published: September 2022

Background: Usually, the fracture of the medial malleolus is seen through supination-adduction loading of the talus on the articular surface which is mostly a vertical shear fracture. This fracture is managed with various methods including open reduction and internal fixation and antiglide plating. Aim: The present study was done to evaluate the functional and radiological outcomes following open reduction and internal fixation using antiglde plates in vertical shear medial malleolus fracture. Methods: This present prospective clinical study included 44 subjects with vertical shear medial malleolus fracture managed with the antiglide plates. In all subjects clinical and radiographic evaluation was done, tenderness, and union time were assessed at follow-up at 1, 2, and 6 months. Results: The mean union time was found to be 12.29±1.96 weeks. Tempo loss was reported in 27.2% (n=12) study subjects and work remained similar to the pre-surgery work in 72.7% (n=32) study subjects respectively. Pain while walking on uneven surfaces was reported by 18.1% (n=8) of the study subjects. Molandar scores were 92.93±3.69 in the study subjects with a range of 10 between 86-96. The median was found to be 95 (91.23-95) in the study participants.