bluuebunny/crossref_metadata_2025 huggingface dataset:
Lung cancer incidence and mortality in trend and prediction between 2012-2030 in Shandong Province, using a Bayesian age-period-cohort model
Authors: Jiang Fan , Fu Zhentao , Chu Jie , Ren Jie , Xu Chunxiao , Xu Xiaohui , Guo Xiaolei , Lu Zilong , Xu Aiqiang
Published: December 2024

Objectives

Lung cancer is one of the most common cancers in Shandong Province, China. Projecting future cancer trend is crucial for planning cancer control. We aimed to examine the trend of lung cancer incidence and mortality from 2012 to 2023, and predict the lung cancer burden to 2030 in Shandong.

Methods

Data of lung cancer incidence and mortality from 2012 to 2023 were obtained from the Shandong Cancer Registries. The average annual percentage change (AAPC) was used to quantify the trend of the lung cancer age-standardised rate using Joinpoint software. Bayesian age-period-cohort model was used to predict lung cancer incidence and mortality from 2024 to 2030.

Results

The age-standardised incidence rate (ASIR) remained stable from 2012 to 2023. The ASIR in males decreased with an AAPC of -1.350%, while the ASIR in females increased with an AAPC of 2.429%. The age-standardised mortality rate (ASMR) decreased with an AAPC of -2.911%. This trend was also observed in males (AAPC=-2.513%), females (AAPC=-3.632%), urban areas (AAPC=-3.267%) and rural areas (AAPC=-2.603%). For our predictions, the ASIR will increase to 49.21 per 100,000 until 2030, with an AAPC of 1.873%. This upward trend is expected for females and urban areas, with an AAPC of 4.496% and 4.176%, while it is not observed for males and rural areas. The ASMR is expected to remain stable up to 2030, and this trend will maintain both in males and females. The ASMR will exhibit an upward trend (AAPC=1.100%) in urban areas and a downward trend (AAPC=-0.915%) in rural areas.

Conclusion

The ASIR of lung cancer will increase until 2030, while the ASMR of lung cancer is expected to remain stable in Shandong. It is necessary to take further preventive measures such as strengthening tobacco control, enhancing health education and expanding screening efforts.
Cervical intraepithelial neoplasia and cervical cancer in Hunan Province, China, 2020-2023
Authors: Zhou Xu , Han Ting , Guo Tingting , Liu Yaqin , Li Hongyun , Yingxia Wang , Wu Yinglan
Published: December 2024

Objective

To describe the incidence and distribution of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC) for rural women aged 35-64 in Hunan Province, China, 2020-2023.

Methods

Data were from the Hunan Provincial Cervical Cancer Screening Program in Rural Areas. Most rural women aged 35-64 in Hunan Province attend the program. All women diagnosed with CINs and CCs will be asked to register detailed information, including pelvic examination, diagnosis, age, education level, etc. CINs included low-grade squamous intraepithelial lesions (LSIL) (CIN1), high-grade squamous intraepithelial lesions (HSIL) (CIN2 and 3); CCs included adenocarcinoma in situ (AIS), early invasive cervical cancer (EICC) (stage Ia1 and Ia2) and invasive cervical cancer (ICC) (stage Ib and above). The incidence of CIN and CC is the number of cases per 1000 women. Chi-square tests (χ2) were used to examine if there were significant differences in proportions among different groups.

Results

A total of 4150700 women were included, and 67071 CINs and CCs were identified. The incidence of LSIL, HSIL, AIS, EICC and ICC were 10.63‰(95%CI: 10.53-10.73), 4.98‰(95%CI: 4.91-5.05), 0.06‰(95%CI: 0.06-0.07), 0.23‰(95%CI: 0.22-0.25), and 0.26‰(95%CI: 0.24-0.27), respectively. The proportion of previous pelvic examinations was relatively low in EICC (17.24%) and ICC (17.45%) (χ2 = 236.57, P <0.01), present abnormal examination was relatively high in AIS (51.33%), EICC (49.74%) and ICC (62.45%) (χ2 = 331.15, P <0.01). HPV16 was the most common high-risk type for LSIL (22.01%), HSIL (36.92%), AIS (46.01%), EICC (58.88%), and ICC (64.34%). The proportion of HSIL was relatively high in women aged 35-44 (27.03%), AIS was relatively high in women aged 45-54 (46.39%), EICC (44.24%), and ICC (48.58%) was relatively high in women aged 55-64. The proportion of ICC was relatively high in women with elementary school (38.68%), HSIL (15.10%) and AIS (17.49%) was relatively high in women with senior high school, AIS (1.52%), EICC (0.62%) and ICC (0.75%) was relatively low in women with university and above. (P <0.01).

Conclusion

We have described the incidence and distribution of CIN and CC among rural women aged 35-64. These findings were clinically relevant and were useful for clinical counseling and early diagnosis of CC.
Targeting the SMURF2-HIF1α axis: a new frontier in cancer therapy
Authors: Youssef Emile , Zhao Shuai , Purcell Connor , Olson Gary L. , El-Deiry Wafik S.
Published: December 2024

The SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) has emerged as a critical regulator in cancer biology, modulating the stability of Hypoxia-Inducible Factor 1-alpha (HIF1α) and influencing a network of hypoxia-driven pathways within the tumor microenvironment (TME). SMURF2 targets HIF1α for ubiquitination and subsequent proteasomal degradation, disrupting hypoxic responses that promote cancer cell survival, metabolic reprogramming, angiogenesis, and resistance to therapy. Beyond its role in HIF1α regulation, SMURF2 exerts extensive control over cellular processes central to tumor progression, including chromatin remodeling, DNA damage repair, ferroptosis, and cellular stress responses. Notably, SMURF2’s ability to promote ferroptotic cell death through GSTP1 degradation offers an alternative pathway to overcome apoptosis resistance, expanding therapeutic options for refractory cancers. This review delves into the multifaceted interactions between SMURF2 and HIF1α, emphasizing how their interplay impacts metabolic adaptations like the Warburg effect, immune evasion, and therapeutic resistance. We discuss SMURF2’s dual functionality as both a tumor suppressor and, in certain contexts, an oncogenic factor, underscoring its potential as a highly versatile therapeutic target. Furthermore, modulating the SMURF2-HIF1α axis presents an innovative approach to destabilize hypoxia-dependent pathways, sensitizing tumors to chemotherapy, radiotherapy, and immune-based treatments. However, the complexity of SMURF2’s interactions necessitate a thorough assessment of potential off-target effects and challenges in specificity, which must be addressed to optimize its clinical application. This review concludes by proposing future directions for research into the SMURF2-HIF1α pathway, aiming to refine targeted strategies that exploit this axis and address the adaptive mechanisms of aggressive tumors, ultimately advancing the landscape of precision oncology.
High-intensity focused ultrasound (HIFU) assisted by a rectal Foley catheter for the treatment of recurrent mucinous ovarian cancer: a case report and literature review
Authors: Guo Xiaoyin , Liu Wei , Zhou Kun , Zhu Hui , Pan Lu , Feng Chunping , Liu Ling
Published: December 2024

​Mucinous ovarian cancer (MOC) is characterized by high malignancy, poor prognosis and a high recurrence rate. Surgical adjuvant chemotherapy is the main treatment for MOC. The recurrence rate of advanced mucinous ovarian cancer following surgery is significantly high, with limited efficacious treatment options available. Moreover, chemotherapy alone results in low sensitivity in this context. High-intensity focused ultrasound (HIFU) not only efficiently ablates targeted tumor lesions but also elicits an immune response within the body and increases tumor cell susceptibility to drugs, thus increasing therapeutic effectiveness. We report a case of recurrent mucinous ovarian cancer treated with HIFU combined with chemotherapy, which effectively controlled tumor growth and prolonged patient survival. High-intensity focused ultrasound in combination with chemotherapy for the treatment of recurrent and surgically difficult ovarian cancer could provide new treatment strategies.
Deep brain stimulation combined with morroniside promotes neural plasticity and motor functional recovery after ischemic stroke
Authors: Chen Yanxi , Xu Zhidong , Ma Yifu , Liu Tingting , Tian Xin , Zhu Zixin , Zheng Wenrong , Wang Yufeng , Zheng Ruifang , Xing Jianguo , Wang Wen , Sun Fangling
Published: December 2024

Background and Objective

Until now, there has been an unmet need for treatments promoting chronic-phase post-stroke functional recovery. We previously found that morroniside promoted endogenous neurogenesis in ischemic stroke, but its therapeutic window was limited to the first 48 h. Here, we aimed to explore whether deep brain stimulation (DBS) combined with morroniside could enhance neurogenesis in rats subjected to focal ischemic stroke and contributes to functional recovery.

Methods

Beginning 2 weeks after the endothelin-1-induced stroke, rats were administered DBS of lateral cerebellar nucleus consecutively for 14 days, followed by morroniside for 7 consecutive days post-stimulation. Behavioral tests were used for assessing motor function. Local field potentials were recorded to evaluate neuronal excitability. Nissl staining was used to assess infarct volume. Immunofluorescence staining and Western blotting were carried out to uncover the stroke recovery mechanisms of DBS combined with morroniside treatment.

Results

The results showed that this combined treatment improved behavioral outcomes, enhanced cortical local field potentials, and diminished infarct volumes at 35 days post-stroke. Moreover, it notably amplified neurogenic responses post-stroke, evidenced by the proliferation of BrdU/SOX2 and BrdU/DCX in the subventricular zone, and their subsequent differentiation into BrdU/NeuN and BrdU/VgulT1 in the ischemic penumbra. Moreover, the combined treatment also elevated the amount of BrdU/Olig2 and the level of axonal sprouting-related proteins in the perilesional cortex.

Conclusion

Our results demonstrated that the combined treatment extended the neurorestorative efficacy of morroniside, reduced infarct size, enhanced neuronal excitability and accelerated sensorimotor function recovery. This therapeutic approach may emerge as a potential clinical intervention for chronic ischemic stroke.
Modeling development of breast cancer: from tumor microenvironment to preclinical applications
Authors: Tang Ruizhi , Liu Xi-Qiu
Published: December 2024

Breast cancer is a complex disease and its progression is related not only to tumor cells but also to its microenvironment, which can not be sufficiently reflected by the traditional monolayer cell culture manner. The novel human cancer models comprising tumor microenvironment (TME), such as tumor organoids and organs-on-a-chip, has been established in recent years to help elucidate the underlying mechanisms of tumorigenesis and promote the development of cancer therapies. In this review, we first discuss the current state of breast cancer and their treatment strategies, and elucidates the complex properties of TME of breast cancer in vivo. The culture models used in breast cancer research are then summarized with insights into recent development. Finally, we also conclude by discussing the current limitations and future directions of culture models in breast cancer research for providing a preclinical reference for the precise treatment of cancer patients.
First-time report on compound isolation from two Colocasia species: vegetable-derived bioactive metabolites and their medicinal potential
Authors: Alam Safaet , Richi Fahmida Tasnim , Emon Nazim Uddin , Chowdhury Abu Asad , Hasan Choudhury Mahmood , Haque Mohammad Rashedul
Published: December 2024

Background

Colocasia affinis Schott and Colocasia gigantea Hook.f. are two commonly found vegetable species of the genus Colocasia, found mainly in the Asian region.

Objectives

The objective of this study was to isolate bioactive phytochemicals from C. affinis and C. gigantea and elucidate their structure employing the NMR technique followed by bioactivity evaluation.

Methodology

Column chromatography was utilized to isolate phytochemicals, followed by NMR analysis for characterization. An in vivo analgesic test was performed through an acetic acid-induced writhing test, an anti-inflammatory test was performed through a formalin-induced licking test, and an antidiarrheal test was performed through a castor oil-induced diarrhea model. The in vitro antimicrobial test was executed through the disc diffusion method. Computer-aided simulation was also implemented to validate the wet laboratory results.

Results

Six compounds from C. affinis and C. gigantea were isolated and characterized from the dichloromethane (DCM)-soluble fractions of the methanolic extracts of these two species. Three of the compounds were from C. gigantea and proposed as penduletin (C1), a mixture of α-amyrin (C2a), β-amyrin (C2b), and monoglyceride of stearic acid (C3), while the remaining three compounds were from C. affinis and proposed as penduletin (C4) (which was also isolated from C. gigantea), 7,8-(3″,3″-dimethyl-pyrano)-4′-hydroxy flavonol (C5), and lastly a mixture of 7,8-(3″,3″-dimethyl-pyrano)-4′-hydroxy flavonol (C5) and 4′,7,8-trihydroxy flavonol (C6). These compounds showed promising zones of inhibition against Gram-positive and Gram-negative bacteria and fungi. In the antidiarrheal test, C5 demonstrated the highest reduction in castor oil-induced diarrhea (44.44%) at a dose of 20 mg/kg compared to loperamide’s 77.78% reduction. However, the analgesic assessment showed a noteworthy inhibition of acetic acid-induced writhing by C1/C4 and C2 (56.52%) at a dose of 20 mg/kg compared to the 76.09% by diclofenac sodium. In comparison, C2 showed pronounced anti-inflammatory action by 68.15% and 52.06% reduction, respectively, in the early and later phases compared to the ibuprofen’s outcomes of 73.54% and 74.68%. Plausible targets such as dihydrofolate reductase (DHFR) for antimicrobial, kappa opioid receptor (KOR) for antidiarrheal, and cyclooxygenase 2 (COX-2) for anti-inflammatory and analgesic activities showed a noteworthy binding affinity with isolated compounds, and ADME/T studies displayed these phytochemicals’ drug-likeness profiles.

Conclusion

To the best of our knowledge, this is the first report on compound isolation from these plants, which demands further extensive research for more absolute findings.
Calcium sensing receptor regulate claudin-14 via PKA-STAT3 pathway in rat model of nephrolithiasis
Authors: Luo Peiyue , Chen Tao , Zheng Liying , Zou Junrong , Zou Jun , Li Wei , Chen Qi , Cheng Le , Qian Biao
Published: December 2024

Background

The calcium-sensitive receptor (CaSR) has been identified as a key factor in the formation of kidney stones. A substantial body of research has illuminated the function of CaSR in stone formation with respect to oxidative stress, epithelial injury, crystal adhesion, and stone-associated proteins. Nevertheless, as a pivotal molecule in renal calcium excretion, its pathway that contributes to stone formation by regulating calcium supersaturation remains underexplored.

Methods

An in vitro rat calcium oxalate kidney stone model was established through the co-cultivation of calcium oxalate monohydrate (COM) with NRK-52E cells, while an in vivo model was constructed using the ethylene glycol method. Subsequently, the level of the CaSR-claudin-14 pathway was determined. To further elucidate the molecular pathway of CaSR-mediated regulation of claudin-14, drugs were selectively added to the in vitro and ex vivo kidney stone models, and the expression of claudin-14 and the levels of stone formation were detected. Moreover, the direct regulation of claudin-14 by CaSR with STAT3 serving as a transcription factor was examined via the dual luciferase assay. Eventually, a Cldn-14 knockout rat model and a model of kidney stone induction by ethylene glycol were generated using CRISPR-Cas9 technology to further clarify the role of claudin-14 in the CaSR-regulated formation of kidney stones.

Results

In vitro and in vivo observations revealed that calcium oxalate induces high expression of CaSR-claudin-14. Specifically, CaSR regulates claudin-14 expression through phosphorylation modification of STAT3 via protein kinase A (PKA). In vitro, the intervention of PKA and STAT3 reversed the elevated claudin-14 levels and stone formation induced by CaSR. Finally, we generated cldn-14 knockout rats using CRISPR-Cas9 technology and observed that ethylene glycol still induced stone formation in these animals. Nevertheless, the specific activation or inhibition of CaSR demonstrated no notable impact on stone formation.

Conclusion

The results of our study indicate that calcium oxalate crystals induce the activation of the pro-stone pathway of CaSR. That is, activated CaSR regulates claudin-14 levels via the PKA-STAT3 pathway, which further promotes calcium salt stone formation. The role of CaSR in the regulation of stone homeostasis is further enriched.
Protective effect of Huanglian Pingwei San on DSS-induced ulcerative colitis in mice through amelioration of the inflammatory response and oxidative stress
Authors: Dong Gengting , Pang Xiaoyan , Wang Ximin , Peng Lin , Xiao Qili , Guo Shunan , Dai Weibo
Published: December 2024

Introduction

Ulcerative colitis (UC) results in the breakdown of the mucosal barrier caused by persistent inflammation and oxidative stress. Huanglian Pingwei San (HLPWS) is a commonly prescribed traditional Chinese medicine for treating colitis, but the precise mechanism remains unclear. The aim of this study was to systematically investigate the protective effect of HLPWS on UC mice and to elucidate the underlying mechanisms involved.

Materials

UC mouse model was established in C57BL/6 mice via 2.25% dextran sulfate sodium (DSS). The chemical composition of HLPWS was examined through UPLC/MS Q-TOF analysis. The efficacy of HLPWS in treating UC was assessed. A TUNEL assay was used to detect apoptotic cells. An ELISA was used to evaluate the levels of inflammatory cytokines in colon tissues and serum. The percentages of Treg and Th17 cells were measured via flow cytometry. The protein expression in the colonic tissue was validated via immunohistochemistry (IHC) and Western blotting.

Results

HLPWS significantly improved UC symptoms and colon tissue histology in mice. The structure and function of the intestinal barrier were restored by HLPWS treatment, as shown by increased DAO content, reduced levels of FITC-dextran, and increased protein expression of ZO-1, occludin, claudin, and MUC2. HLPWS dose-dependently decreased the number of apoptotic cells by inhibiting P53, P21, P27, cleaved caspase 3, and p-H2AX expression. HLPWS also reduced abnormal oxidative stress by reducing Keap1 expression and increasing Nrf2 and HO-1 levels. Furthermore, HLPWS rebalanced the Treg/Th17 ratio to alleviated inflammatory reactions in UC mice.

Conclusion

These findings suggest that HLPWS alleviated colonic intestinal barrier dysfunction in UC mice by reducing oxidative stress and restoring immune balance. This study underscores the potential therapeutic benefits of HLPWS and highlights its potential as a future pharmaceutical candidate for UC treatment.
Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours
Authors: Xu Chongxi , Tang Yi , Lu Xing , Chen Ruiqi
Published: December 2024

Under normal physiological conditions, Fyn, a nonreceptor tyrosine kinase, is involved in signal transduction pathways in the nervous system and in the formation and activation of T lymphocytes. Fyn is a member of the Src family of kinases (SFKs) and plays a role in cell morphogenic transformation, motility, proliferation, and death, which in turn influences the development and progression of various cancer types. SFKs are overexpressed or hyperactive in tumours, and they are engaged in several signalling pathways that lead to tumour development. Inhibition of Fyn can enhance patient outcomes and prolong survival. Thus, Fyn is a desirable therapeutic target in a variety of tumour types. To lay the groundwork for further investigation and targeted therapy in tumours, in this article, we review the most recent findings on the function of Fyn in tumours, with an emphasis on its role in gliomas. Understanding the function of Fyn during tumourigenesis and development and in resistance to anticancer therapeutic agents can aid in the development and application of innovative medicines that specifically target this kinase, thus improving the management of cancers.
Biomaterials-based phototherapy for bacterial infections
Authors: Wu Guangzhi , Xu Zhuo , Yu Yue , Zhang Minglei , Wang Shuaishuai , Duan Shuo , Liu Xilin
Published: December 2024

Bacterial infections and antibiotic resistance are global health problems, and current treatments for bacterial infections still rely on the use of antibiotics. Phototherapy based on the use of a photosensitizer has high efficiency, a broad spectrum, strong selectivity, does not easily induce drug resistance, and is expected to become an effective strategy for the treatment of bacterial infections, particularly drug-resistant infections. This article reviews antimicrobial strategies of phototherapy based on photosensitizers, including photodynamic therapy (PDT), photothermal therapy (PTT), and their combination. These methods have significant application potential in combating multi-drug-resistant bacterial and biofilm infections, providing an alternative to traditional antibiotics and chemical antibacterial agents.
Genotypic variability in cotton's transpiration response under progressive soil drying
Authors: Broughton Katrina J. , Bate Eleanor L. , Cutler Corey W. , Allen Christopher N. , Thompson Alan J. E. , Conaty Warren C.
Published: December 2024

Introduction

Crop yields in food and fibre production systems throughout the world are significantly limited by soil water deficits. Identifying water conservation mechanisms within existing genotypes is pivotal in developing varieties with improved performance in water-limited conditions. The objective of this study was to screen Australian germplasm for variability in the transpiration response to progressive soil drying using a glasshouse dry-down experiment. It tests the hypothesis that water conservation traits may provide tolerance to water stress, particularly when combined with other drought stress traits.

Methods

Three glasshouse experiments were conducted to identify whether there are differences in the fraction of transpirable soil water (FTSW) threshold values for transpiration decline among six cotton genotypes. We also assessed whether genotype dependent responses to progressive soil drying are evident from leaf-level physiology, by measurement of gas exchange parameters.

Results

Significant variation in the FTSW threshold for transpiration decline between six genotypes was found, ranging from 0.13 to 0.29. Genotypic variation in the response to soil drying was also observed from leaf level physiology, with reductions in stomatal conductance and photosynthetic rate coinciding with when the FTSW threshold was reached.

Discussion

Genotypes that limit transpiration at high FTSW can conserve water earlier in the season to maintain productivity during extended dry periods. Therefore, these genotypes may provide physiological traits that improve productivity in water-limited environments. This research is important as rainfall and water resources for irrigated agriculture are predicted to decline. The development of drought tolerant germplasm for the Australian cotton industry will be beneficial in the projected increasingly frequent limited water environments resulting from a changing climate.
Improving soil carbon sequestration stability in Siraitia grosvenorii farmland through co-application of rice straw and its biochar
Authors: Liu Xuehui , Yang Yu , Xie Yaqi , Zeng Yicheng , Li Ke , Hu Lening
Published: December 2024

Introduction

Susbtantial agricultural wastes are produced globally which need urgent management policies. To explore the effective utilization of agricultural waste in enhancing soil quality and carbon sequestration capacity, straw and its biochar can be applied as soil ameliorants.

Methods

This study was designed to investigate the impact of different return-to-field methods of rice straw on the transformation between different carbon components in the soil of Siraitia grosvenorii fields. We hypothesize that rice straw and its biochar, as soil amendments, can influence the transformation and cycling of different carbon components in the soil of S. grosvenorii fields through various return-to-field methods. Rice straw, rice straw biochar, and “rice straw + rice straw biochar” were applied as additives in a 2-year field experiment.

Results

The results showed that the field application of rice straw and its biochar increased the content of soil organic carbon, the amount of organic carbon mineralization, particulate organic carbon, mineral-associated organic carbon, dissolved organic carbon, and readily oxidizable organic carbon content, while reducing the content of soil microbial biomass carbon. The combined application of rice straw and biochar in S. grosvenorii cultivation fields had a more significant effect on various soil carbon fractions compared to the use of either rice straw or biochar alone. The co-application of rice straw and its biochar to the soil increased the content of soil organic carbon by 117.4%, enhanced the mineralization of organic carbon by 100.0%, and reduced the content of soil microbial biomass carbon by 61.6%. The metabolic entropy and microbial entropy of rice straw and its biochar mixed application in the field were 5.2 and 0.18 times higher than of the control group, respectively.

Discussion

In summary, the return of rice straw and biochar to the field improves soil structure and the content of recalcitrant organic carbon, providing a habitat for microorganisms, thereby promoting the stability and cycling of soil organic carbon.
Lignin-based controlled-release urea improves choy sum growth by regulating soil nitrogen nutrients and bacterial diversity
Authors: Chen Xiaojuan , Lu Bosi , Lv Bowen , Sun Shaolong
Published: December 2024

Lignin, as one of the few renewable resources among aromatic compounds, exhibits significant potential for applications in the agricultural sector. Nonetheless, there has been relatively limited research on the effects of lignin-based controlled-release urea (LCRU) on soil nitrogen nutrition and bacterial diversity. In this paper, the impact of LCRU on the growth of choy sum was investigated through a two-season field experiment. The findings suggest that the plant height, stem diameter, SPAD value, and above-ground dry weight under LCRU application surpassed those with conventional urea (CU), increasing by 40.27%, 26.97%, 52.02%, and 38.62%, respectively. Furthermore, the condition that the urea content was reduced by 15% (LCRU15) caused improvements of 24.76%, 26.97%, 43.23%, and 30.86% in the respective variables. Additionally, compared with the CU, the contents of vitamin C, soluble sugar, and soluble protein in choy sum were increased by the LCRU and LCRU15 treatments, and yet no significant differences were observed between the LCRU and LCRU15 treatments. Notably, the nitrogen used efficiency of choy sum increased to 68.90% with the LCRU15 treatment, compared to 64.29% with the LCRU treatment. The levels of soil available nitrogen, NO3−−N, and NH4+−N were augmented by the LCRU and LCRU15 treatments. Meanwhile, soil urease and nitrate reductase activities were increased by 22.4%-28.6% and 12.3%-14.5%, respectively. Moreover, soil high-throughput sequencing results illustrated that the LCRU15 treatment enhanced the diversity and abundance of bacteria, particularly the abundance of Actinobacteria, Firmicutes, and Cyanobacteria, which can accelerate the decomposition of organic matter. In short, LCRU improves choy sum yield by influencing soil properties, enzyme activity, and microbial communities. These findings are anticipated to offer practical value for the sustainable application of LCRU in agriculture.
The role of cognitive motivation and self-regulation in coping with occupational demands
Authors: Hoff Inga , Farkas Aniko , Melicherova Ursula , Köllner Volker , Hoyer Jürgen , Strobel Alexander , Strobel Anja
Published: December 2024

Cognitive motivation (COM) in conjunction with self-regulation (SR) was demonstrated to be positively linked to mental health in educational and clinical contexts. We introduce COM and SR in the occupational context and hypothesize these traits—based on their conceptual link to hardiness - to counteract health-risking stressors. Data from two large cross-sectional studies in Germany comprise a sample of 1,022 psychosomatic rehabilitation in-patients and a healthy sample of 298 employees of various occupations. Using bootstrapping in correlation analyses, we found in both samples COM and SR to be especially associated with an active, meaningful, and persistent coping style (0.31 ≤ r ≤ 0.57). Analyses via structural equation modeling found COM cross-sectionally predicting occupational coping via SR in both samples. We discuss COM and SR as personal resources with respect to Conservation of Resources Theory and provide ideas for promoting these variables in patients and employees.
The mediating effects of mobile phone use on ADHD and educational outcomes: a two-step Mendelian randomisation study
Authors: Lin Huize , Yuan Sitong , Yu Jinna
Published: December 2024

Objective

This study investigates the potential mediating role of mobile phone screen time in the causal relationships between Attention-deficit/hyperactivity disorder (ADHD) and educational attainment. Our analysis explores both the effect of ADHD on educational outcomes and the reverse, i.e., the influence of educational attainment on ADHD risk.

Method

A two-sample Mendelian randomisation (MR) analysis was conducted using genetic instruments from genome-wide association studies (GWAS) of European populations. We employed a two-step MR approach to assess the causal effects between ADHD, mobile phone screen time (both frequency and duration), and educational outcomes, including years of full-time education and college completion. Data from public genome-wide association studies encompassing European populations with sample sizes ranging from 55,374 to 470,941 were utilised.

Results

We found significant causal associations between childhood ADHD and educational attainment, partially mediated by mobile phone screen time. Childhood ADHD was negatively linked to years of full-time education (IVW: OR = 0.93, 95% CI = 0.90-0.97, p = 0.000) and college completion (IVW: OR = 0.97, 95% CI = 0.95-0.98, p = 0.000). Mobile phone use frequency mediated 19.3% of the effect on full-time education (β = -0.158) and 11.9% on college completion (β = -0.084). The duration of phone use mediated 64.8% of the effect on college completion (β = -0.054). When ADHD was the outcome, phone use duration mediated -22.45% of full-time education effects (β = 0.426) and -19.62% of college completion (β = 0.433).

Conclusion

Different MR models reveal the complex mediation role of mobile phone use frequency and duration between ADHD and educational attainment, varying by educational outcome type. Frequency mediates the link between childhood ADHD and full-time education/college completion, while duration significantly impacts ADHD when higher education is the outcome. The notable mediation effect of duration on ADHD underscores the need for further study into screen time’s influence on ADHD and academic achievement across stages.
Psychological distress in biliary tract malignancy patients: influencing factors and development of a predictive nomogram model
Authors: Gou Zhennan , Liu Yuhua , Tang Wenjie , Zhou Changming , Lu Zhenqi , Wang Lu , Feng Wei , Xu Weiqi , Wang Jun
Published: December 2024

Objective

This study aims to investigate the psychological distress and its influencing factors in patients with biliary tract malignant tumors, alongside the development of a predictive model.

Methods

A total of 219 patients diagnosed with biliary tract malignant tumors who were admitted to the Department of Liver Surgery at Fudan University Shanghai Cancer Center from July 2021 to May 2023, were selected using a convenience sampling method. Research tools involve psychological distress management screening tools, a demographic questionnaire, self-rating anxiety and depression scales, and the Chinese version of the Memorial Symptom Assessment Scale. Bootstrap method was utilized for repeated sampling to identify relevant factors influencing psychological distress in biliary tract cancer patients. The R software was employed to create a nomogram model, and the model’s accuracy and predictive performance were assessed using the receiver operating characteristic curve (ROC) and the Hosmer-Lemeshow test.

Results

The average score of psychological distress among the 219 patients was (3.91 ± 2.44), with a psychological distress detection rate of 54.8%. Regression model results indicated that factors such as the presence of distant metastasis, comorbidity with other major diseases, poor sleep quality, anxiety, and severity of anxiety and depression were the primary influencers of psychological distress.

Conclusion

The detection rate of psychological distress in patients with biliary tract malignant tumors is notably high. The predictive model constructed in this study exhibits good predictive efficacy and clinical value, providing valuable reference for healthcare professionals in developing targeted intervention strategies.
Effects of BMI and grip strength on older adults' falls—A longitudinal study based on CHARLS
Authors: Huang Lei , Shen Xiaoxin , Zou Yuliang , Wang Yanming
Published: December 2024

Background

Body Mass Index (BMI) and grip strength are potentially important risk factors for falls among the older adults. Currently, there is no consensus on the combined effects of grip strength and BMI on falls in the older adults, particularly among the Chinese older adults.

Objective

To investigate the incidence of falls among older adults in China and explore the association between BMI and grip strength and the risk of falls in older adults.

Methods

Data of participants over 60 in China Health and Retirement Longitudinal Study in 2011 and 2013 were collected. Sociodemographic variables, lifestyle, chronic disease status, history of falls and depression and cognitive status were obtained through the 2011 baseline questionnaire. Height, weight and grip strength were collected from a unified physical examination in 2011. Falls during the follow-up period were obtained through the follow-up questionnaire in 2013. Logistic regression was used to explore the association between BMI and grip strength and the risk of falls.

Results

Three thousand six hundred and eighty-five participants over 60 (67.14 ± 6.08) were included, with a fall incidence rate of 17.37%. The fall incidence rate in females (21.15%) was higher than that in male (13.46%). After adjusting covariates, high grip strength was associated with lower falls risks in general population (OR = 0.76; 95 CI: 0.630–0.923) and males (OR = 0.68; 95 CI: 0.503–0.919). Underweight was associated with lower falls risks in general population (OR = 0.77; 95 CI: 0.595–0.981) and females (OR = 0.69; 95 CI: 0.486–0.962) compared to the normal BMI group. Compared with the low grip strength group, females with high grip strength (OR = 0.54; 95 CI: 0.29–0.98) had a lower risk of falls in the underweight BMI group and males with high grip strength (OR = 0.63; 95 CI: 0.43–0.92) had lower risk of falls in the normal BMI group.

Conclusions

High grip strength and underweight BMI are independently correlated with a lower fall risk, which varies between males and females.
Unveiling autism spectrum disorder in South East Asia through a public health Lens
Authors: Kumar Alok , Bhattacharya Sudip
Published: December 2024

Autism spectrum disorder (ASD) is a multifaceted developmental condition characterized by persistent challenges in social communication, restricted interests, and repetitive behaviors. Though there is no cure, early and intensive interventions can significantly improve the quality of life for those affected. The aim of this paper is to examine the complexities of autism spectrum disorder (ASD) from a public health perspective in South East Asian region, highlighting the global rise in prevalence and the compounded challenges posed by the COVID-19 pandemic. The rise in ASD prevalence from 4 to 5 cases per 10,000 children in the 1980s to 11.3 per 1,000 children in 2012 highlights the need for effective interventions. The pandemic exacerbated behavioral issues, anxiety, and screen time-related health problems, underscoring the importance of adjusting strategies for early identification and support. Diagnostic tools like the Modified Checklist for Autism in Toddlers (M-CHAT) and the Social Communication Questionnaire (SCQ) play a critical role in community-based screening. Effective prevention strategies include primary measures such as public awareness campaigns and genetic counseling, secondary measures focusing on early identification and intervention, and tertiary measures involving ongoing support and therapy. Addressing implementation challenges, particularly in low-income countries, requires enhanced public awareness, training of community health workers, and integration of ASD services into primary healthcare systems. Future research should aim to develop and evaluate scalable, culturally relevant interventions and explore the impact of environmental factors on ASD. Comprehensive strategies at the community level, combined with robust public health policies, are crucial for improving outcomes for individuals with ASD and their families.
“The package has been opened”- parents' perspective and social validity of an Early Start Denver Model intervention for young children with autism
Authors: Carlsson Emilia , Nygren Gudrun , Gillberg Christopher , Linnsand Petra
Published: December 2024

Introduction

This study aimed to capture experiences and perspectives of parents of children with autism participating in an intervention program based on the Early Start Denver Model (ESDM). Specifically, we wanted their views regarding feasibility, acceptability, and significance of the intervention program, i.e., its social validity.

Methods

Fourteen parents, whose children has been diagnosed with autism, were interviewed.

Results

The results included three themes (1) Comprehensive approach: the participants emphasized the importance of early detection and interventions in their local setting in close cooperation between themselves, health care professionals, and preschool staff. They also highlighted the individual goals based on the child's needs in different developmental areas, as well as the whole family's needs and prioritizations. (2) Hands on—available locally and accessible: focused on different aspects of procedures, including features of the ESDM, parent education, the parent-therapist relationship and nearby location. (3) Sense of empowerment—parents got increased knowledge: the intervention was significant within family daily living and daily activities. The participants expressed that the interventions program contributed to an increased knowledge about autism and the ESDM strategies, positively impacted their child, and improved the collaboration with the preschool.

Conclusion

Parents emphasized the naturalistic, comprehensive, and local setting of the intervention and described that they had gained new knowledge as well a sense of empowerment. The results indicated that the intervention program based on the ESDM was socially valid according to parent descriptions.
Profession-specific working conditions, burnout, engagement, and turnover intention: the case of Hungarian social workers
Authors: Győri Ágnes , Ádám Szilvia
Published: December 2024

Introduction

This study investigated the interactions of profession-specific working conditions, burnout, engagement, and turnover intent among social workers in Hungary. Research on turnover among employees in human services occupations often overlooks the mechanism linking professional-specific factors with turnover intention.

Methods

Using a multistage stratified sampling method and cross-sectional design with a random sample of 664 participants, data were collected through computer-assisted personal interviews.

Results

The findings revealed that poor working environments, workplace struggles, and profession-specific factors, such as challenges stemming from clients' difficult life situations, difficulties with client engagement, cultural disparities, and fieldwork-related challenges, significantly influenced turnover intentions. These factors not only directly affected professionals' intentions to leave but also had indirect effects through burnout and work engagement.

Discussion

Our findings highlighted the importance of addressing both general and profession-specific working conditions to reduce turnover intention among social workers. Key challenges included clients' difficult life situations, cooperation with clients, cultural differences, and fieldwork difficulties. Overall, preparing social workers for real-life situations and related conflicts should be incorporated into their training.
Family structure and women’s mental well-being: how family stressors explain mental health inequalities between lone and partnered mothers
Authors: McDonnell Cadhla , Gracia Pablo
Published: December 2024

Lone mothers have been found to report lower average mental health than partnered mothers. Following the ‘stress process model’, disparities in women’s mental health by family structure could be explained by lone mothers’ higher exposure to multiple forms of stressors, compared to partnered mothers. Yet, this hypothesis has not been tested in previous studies. This study analysed four waves of longitudinal data from the Growing Up in Ireland study, spanning between the year when women gave birth (2008) to 9 years later (2017) (N = 5,654 women), to examine how family stressors (i.e., financial strain, caregiving strain, work-related strain, and parental conflict) influence mothers’ depressive symptoms by family structure. Analyses applied random-effects models and Karlson-Holm-Breen (KHB) decomposition techniques, combined with different model specifications as robustness checks (i.e., fixed-effects). Results indicate that: (1) net of sociodemographic factors, lone mothers experience higher levels of depressive symptoms than partnered mothers, with additional analyses confirming that transitioning from partnered to lone mother is associated with higher depressive symptoms, and from lone to partnered mother with reduced depressive symptoms; (2) although 41% of the observed statistical association between family structure and mothers’ depressive symptoms is direct, a larger 59% of this mental health gap is mediated by inequalities between lone and partnered mothers in their exposure to family stressors; and (3) the largest share of the observed mediation by family stressors is explained by lone mothers’ higher risks of current and past caregiving strain and parental conflict, but also by their current higher financial strain. Overall, this study suggests that lone mothers’ lower mental health, compared to partnered mothers, is largely explained by disparities in exposure to family stressors, pointing to how accumulated caregiving and parental stressors, as well as poverty risks, are key explanatory factors behind the mental well-being disadvantage that lone mothers face.
An exploratory qualitative study of the experiences of women in volunteer non-player roles in Australian community football clubs
Authors: Morgan Joanne M. , Lovell G. P. , Tulloch K.
Published: December 2024

Introduction

Women are underrepresented in volunteer non-player roles in community sporting clubs, particularly in traditionally male sports such as football (soccer), where participation rates for men and boys remain higher than women and girls. Experiences of women volunteering in community sporting clubs are not well-represented in research literature. By exploring women's experiences volunteering in community Australian Football clubs, the present research aimed to understand the barriers and facilitators of women's participation in volunteer non-player community sport club roles. Our intention is that our findings will provide empirical basis for the design of efficacious evidence-based interventions and initiatives to help close the gender gap of volunteerism rates and experiences, thus facilitating equal opportunities for women to access associated individual social, physical, and mental health benefits of sports volunteering.

Method

We conducted individual semi-structured interviews with six women from four Australian Football clubs, to determine barriers and facilitators to volunteering.

Results

Reflexive thematic analysis of barriers generated six themes: high expectations of self, intersectionality (of gender with motherhood or race), constrained resources, interpersonal disconnection, lack of organisational support and structure, and gender role assumptions and stereotypes. Analysis of facilitators produced six themes: having or building confidence, positive reinforcement, social connection, deliberate efforts to engage women, role autonomy and shaping, and supportive culture within a club or governing body.

Discussion

Findings revealed that impacts on women's development in non-player roles exist at the individual level, including the interaction of gender, race, and parental status, but also extend beyond this to personal, interpersonal, organisational, and sociocultural factors. Given our research findings we make seven recommendations for governing bodies and community football clubs to enhance volunteering gender equity: 1. Establish support for women by dividing work evenly among volunteers; 2. Provide clear descriptions of non-player roles; 3. Match the skill sets of new women volunteers to suitable roles; 4. Implement mentorship programs to aid collaboration among women who volunteer; 5. Educate communities about gender biases and assumptions; 6. Monitor and seek feedback on gendered task allocation to ensure women's unpaid labour is not disproportionate to men's; and 7. Promote and publicise women in non-player roles to enhance women's visibility and acceptance in community football clubs
Recreational sports in prison: inmates' perspectives on coaching effectiveness
Authors: Dransmann Milan , Lesch Lara , Gröben Bernd , Wicker Pamela
Published: December 2024

Introduction

This study examines inmates' perspectives on the effectiveness of sports coaches in prison. According to the integrative definition of effective coaching, coaches require professional, interpersonal, and intrapersonal knowledge to enhance athletes' outcomes within a specific context.

Methods

Five male inmates of a German prison were interviewed after they participated in sports programs. The data were analyzed using directed content analysis.

Results

The inmates recognized professional knowledge in coaches who demonstrated clear training structures and spoke in an educated manner. Interpersonal knowledge was highly valued, with inmates expressing a preference for coaches who showed closeness, truthfulness, and responsiveness, while intrapersonal knowledge was attributed through coaches' adaptability. Inmates identified all four possible outcomes and emphasized that sensitivity, authenticity, energetic demeanor, physical appearance, and athletic skills are crucial qualities for an effective coach in a prison.

Discussion

The balance between an authentic and energetic demeanor, including a certain degree of strictness, emerges as a key factor in effective coaching within the prison context.