bluuebunny/crossref_metadata_2025 huggingface dataset:
Proof-of-Familiarity: A Privacy-Preserved Blockchain Scheme for Collaborative Medical Decision-Making
Authors: Yang Jinhong , Onik Md Mehedi Hassan , Lee Nam-Yong , Ahmed Mohiuddin , Kim Chul-Soo
Published: April 2019

The current healthcare sector is facing difficulty in satisfying the growing issues, expenses, and heavy regulation of quality treatment. Surely, electronic medical records (EMRs) and protected health information (PHI) are highly sensitive, personally identifiable information (PII). However, the sharing of EMRs, enhances overall treatment quality. A distributed ledger (blockchain) technology, embedded with privacy and security by architecture, provides a transparent application developing platform. Privacy, security, and lack of confidence among stakeholders are the main downsides of extensive medical collaboration. This study, therefore, utilizes the transparency, security, and efficiency of blockchain technology to establish a collaborative medical decision-making scheme. This study considers the experience, skill, and collaborative success rate of four key stakeholders (patient, cured patient, doctor, and insurance company) in the healthcare domain to propose a local reference-based consortium blockchain scheme, and an associated consensus gathering algorithm, proof-of-familiarity (PoF). Stakeholders create a transparent and tenable medical decision to increase the interoperability among collaborators through PoF. A prototype of PoF is tested with multichain 2.0, a blockchain implementing framework. Moreover, the privacy of identities, EMRs, and decisions are preserved by two-layer storage, encryption, and a timestamp storing mechanism. Finally, superiority over existing schemes is identified to improve personal data (PII) privacy and patient-centric outcomes research (PCOR).
Research on Control Methods for the Pressure Continuous Regulation Electrohydraulic Proportional Axial Piston Pump of an Aircraft Hydraulic System
Authors: Zhang Peng , Li Yunhua
Published: April 2019

The objective of this paper is to design a pump that can match its delivery pressure to the aircraft load. Axial piston pumps used in airborne hydraulic systems are required to work in a constant pressure mode setting based on the highest pressure required by the aircraft load. However, the time using the highest pressure working mode is very short, which leads to a lot of overflow lose. This study is motivated by this fact. Pressure continuous regulation electrohydraulic proportional axial piston pump is realized by combining a dual-pressure piston pump with electro-hydraulic proportional technology, realizing the match between the delivery pressure of the pump and the aircraft load. The mathematical model is established and its dynamic characteristics are analyzed. The control methods such as a proportional integral derivative (PID) control method, linear quadratic regulator (LQR) based on a feedback linearization method and a backstepping sliding control method are designed for this nonlinear system. It can be seen from the result of simulation experiments that the requirements of pressure control with a pump are reached and the capacity of resisting disturbance of the system is strong.
Preparation and Characterization of Hybrid Nanocomposites for Dental Applications
Authors: Gawdzinska Katarzyna , Paszkiewicz Sandra , Piesowicz Elzbieta , Bryll Katarzyna , Irska Izabela , Lapis Agnieszka , Sobolewska Ewa , Kochmanska Agnieszka , Slaczka Wojciech
Published: April 2019

The study involved research related to the selection of the material with improved functional properties that can be used for dental prostheses. An innovative system of nanofillers, that differ in shape, by means of gelatin-modified halloysite nanotubes (HNTs-g) along with silane-coupled aluminum trihydrate (ATH-sil) was prepared, in order to observe a synergistic improvement of acrylic material (methyl methacrylate with methyl methacrylate monomer (MM/mMM)). Selected mechanical properties of manufactured nanocomposites, along with utilitarian properties, like hardness, buffer solution absorption, and abrasion resistance, along with a fall test from the height of finished products have been discussed. Moreover, the study of the biofilm formation on the surface of dental prostheses confirmed the occurrence of a synergistic improvement of properties and the legitimacy of using modified mineral nanofillers in the form of a hybrid system.
Evaluation of Semi-Continuous Pit Manure Recharge System Performance on Mitigation of Ammonia and Hydrogen Sulfide Emissions from a Swine Finishing Barn
Authors: Wi Jisoo , Lee Seunghun , Kim Eunjong , Lee Myeongseong , Koziel Jacek A. , Ahn Heekwon
Published: April 2019

In this research, for the first time, we present the evaluation of a semi-continuous pit manure recharge system on the mitigation of ammonia (NH3) and hydrogen sulfide (H2S) emissions from a swine finisher barn. The pit recharge system is practiced on many swine farms in the Republic of Korea, primarily for improving air quality in the barn. It consists of an integrated waste management system where the fraction of stored manure is pumped out (10× of the daily production of manure, 3× a day); solids are separated and composted, while the aerobically treated liquid fraction is then returned to the pit. We compared emissions from two 240-pig rooms, one equipped with a pit recharge system, and the other operating a conventional slurry pit under the slatted floor. Mean reduction of NH3 and H2S emissions were 49 ± 6% and 82 ± 7%, respectively, over 14 days of measurements. The removal efficiency of H2S was higher than NH3, likely because the pH of aerobically treated liquid manure remained slightly above 8. More work is warranted to assess the N balance in this system and the emissions of odor and greenhouse gasses (GHGs). It is also expected that it will be possible to control the NH3 and H2S removal rates by controlling the nitrification level of the liquid manure in the aerobic treatment system.
The Impact of Meteorological and Hydrological Memory on Compound Peak Flows in the Rhine River Basin
Authors: Khanal Sonu , Lutz Arthur F. , Immerzeel Walter W. , Vries Hylke de , Wanders Niko , Hurk Bart van den
Published: April 2019

Spatio-temporal variation of hydrological processes that have a strong lagged autocorrelation (memory), such as soil moisture, snow accumulation and the antecedent hydro-climatic conditions, significantly impact the peaks of flood waves. Ignoring these memory processes leads to biased estimates of floods and high river levels that are sensitive to the occurrence of these compounding hydro-meteorological processes. Here, we investigate the role of memory in hydrological and meteorological systems at different temporal scales for the Rhine basin. We simulate the hydrological regime of the Rhine river basin using a distributed hydrological model (SPHY) forced with 1950–2000 atmospheric conditions from an ensemble simulation with a high resolution (0.11°/12 km) regional climate model (RACMO2). The findings show that meltwater from antecedent anomalous snowfall results in a time shift of the discharge peak. Soil moisture modulates the rainfall-runoff relationship and generates a strong runoff response at high soil moisture levels and buffers the generation of runoff peaks at low levels. Additionally, our results show that meteorological autocorrelation (manifesting itself by the occurrence of clustered precipitation events) has a strong impact on the magnitude of peak discharge. Removing meteorological autocorrelation at time scales longer than five days reduces peak discharge by 80% relative to the reference climate. At time scales longer than 30 days this meteorological autocorrelation loses its significant role in generating high discharge levels.
The Modulating Role of Self-Referential Stimuli and Processes in the Effect of Stress and Negative Emotion on Inhibition Processes in Borderline Personality Disorder: Proposition of a Model to Integrate the Self-Concept and Inhibition Processes
Authors: Gagnon Jean , Aldebert Joséphine , Saleh Gasser , Kim Wan Seo
Published: April 2019

Impulsivity is an important clinical and diagnostic feature of borderline personality disorder (BPD). Even though it has been reported that BPD individuals’ inhibition performance is significantly reduced in the context of negative emotion or stress, this literature shows mixed results, raising questions about the possible role played by other factors. Winter (2016) proposed that negative emotion stimuli can be more disruptive for BPD individuals’ attention control performance because they induce higher distractibility self-referential processes. This article aimed to systematically review the literature regarding the effect of stress and negative emotions on three main inhibition processes—prepotent response inhibition, resistance to distractor interference, and resistance to proactive interference—in BPD and to verify the putative modulating role of self-referential stimuli and processes on these inhibition processes. All English and French experimental studies published until August 2018 were searched in PsychINFO and PubMED databases. The following keywords were used: “borderline* AND inhibit* OR interference* OR forget* OR task* AND emotion* OR stress* OR affect*”. A total of 1215 articles were included in the study. After full text revision, twenty-six papers were selected for review. The results of this review indicate that when stimuli or procedures involve self-reference stimuli or processes, BPD individuals’ performance seems to be more disrupted in all three inhibition processes. A model based on Winter’s and Kernberg’s models is proposed with the aim of integrating the self-concept with inhibition processes in BPD.
The Clinical Outcomes of Locally Advanced Cervical Esophageal Squamous Cell Carcinoma Patients Receiving Curative Concurrent Chemoradiotherapy: A Population-Based Propensity Score-Matched Analysis
Authors: Chen Yen-Hao , Lu Hung-I , Lo Chien-Ming , Wang Yu-Ming , Chou Shang-Yu , Hsiao Chang-Chun , Li Shau-Hsuan
Published: April 2019

This study investigated the clinical outcome of locally advanced cervical esophageal squamous cell carcinoma (ESCC) patients who received curative concurrent chemoradiotherapy (CCRT) and their differences from thoracic ESCC patients. Among 411 enrolled ESCC patients, including 63 with cervical and 348 with thoracic ESCC, 63 thoracic patients were propensity score-matched to the 63 cervical patients. For cervical ESCC, T4b and high tumor grade were independent prognostic factors of a worse overall survival (OS) in univariate and multivariate analyses. The response rates to curative CCRT between cervical and the matched thoracic ESCC groups were similar but cervical ESCC had a better OS than that of the matched thoracic group (21.4 versus 10.1 months, p = 0.012). Better OS was mentioned to be in the patients with complete response (CR), whether in the cervical or matched thoracic ESCC group. For patients without CR, patients who underwent esophagectomy had superior OS than those without operation in the matched thoracic ESCC group (11.6 versus 11.9 months, p = 0.73). Only three patients received operation in the cervical ESCC group, thus the survival difference was not significant. Curative CCRT may be a reasonable treatment for cervical ESCC in clinical practice, and the role of surgery should be considered as salvage therapy if residual disease is evident.
TERT Promoter Mutations are Associated with Visceral Spreading in Melanoma of the Trunk
Authors: Osella-Abate Simona , Bertero Luca , Senetta Rebecca , Mariani Sara , Lisa Francesco , Coppola Vittoria , Metovic Jasna , Pasini Barbara , Puig S Susana , Fierro Maria Teresa , Manrique-Silva Esperanza , Kumar Rajiv , Nagore Eduardo , Cassoni Paola , Ribero Simone
Published: April 2019

Survival predictions are currently determined on the basis of NRAS/BRAF mutations, even though TERT promoter mutations have been recently associated with a poor prognosis in stage I-II melanomas. Usually, it is not recommended to perform a mutational test on primary melanoma, as the results do not always reflect the mutational status of metastases. In particular, trunk melanomas have been reported to have an unfavourable prognosis. A series of 105 advanced melanoma patients were analysed by TERT promoter Sanger sequencing. Univariate/multivariate binary logistic regression models were performed using progression to a visceral site as the dependent variable and patient/tumour characteristics as covariates. Performance of the model was assessed in an external independent primary melanoma patients’ dataset. Male gender (odds ratio (OR), 344; 95% CI, 1.12–10.6; p = 0.031), AJCC (American Joint Committee on Cancer) classification (OR, 022; 95% CI, 0.07–0.67; p = 0.008), SLNB (Sentinel Lymph Node Biopsy) status (OR, 3.05; 95% CI, 1.06–8.78; p = 0.039) and TERT-mutated trunk lesions (OR, 3.78; 95% CI, 1.35–10.6; p =  0.011) were significantly associated with the risk of developing a visceral spreading as first site of progression using multivariate logistic regression analysis. These results were confirmed in the external validation control group. Therefore, in trunk primary melanomas, due to their high risk of progression to visceral sites, we encourage somatic TERT mutation analysis at diagnosis to identify those patients who would potentially benefit from a more intensive follow-up protocol and a prompt initiation of therapy.
Optimization of Hydrogen Yield from the Anaerobic Digestion of Crude Glycerol and Swine Manure
Authors: F. A. Aguilar-Aguilar , Longoria Adriana , A. U. Juantorena , A. S. Santos , L. A. Pantoja , Sebastian P.
Published: April 2019

Crude glycerol and swine manure are residues with exponential production in Mexico, nonetheless, they have the potential to generate hydrogen from the fermentation process. For this reason, this study has evaluated the optimization of hydrogen yield from crude glycerol and swine manure, using the response surface methodology. The response surface methodology helps in the compression of the mixture of crude glycerol/ swine manure, with the production of hydrogen as a result, which improves the yields of the process, reducing variability and time of development. A central composite design was employed with two factors, six axial points and four central points. The two factors evaluated were crude glycerol and swine manure concentrations, which were examined over a range of 4 to 10 g L−1 and 5 to 15 g L−1, respectively. This study demonstrated that the thermal pretreatment method is still the most suitable method to be applied, mainly in the preparation of hydrogen-producing inoculum. The maximum hydrogen yield was 142.46 mL per gram of volatile solid added. It used up 21.56% of the crude glycerol (2.75 g L−1) and 78.44% (10 g L−1) of the swine manure, maintaining a carbon/nitrogen ratio of 18.06, with a fermentation time of 21 days. The response surface methodology was employed to maximize the hydrogen production of crude glycerol/swine manure ratios by the optimization of factors with few assays and less operational cost.
Ex-Situ Electrochemical Characterization of IrO2 Synthesized by a Modified Adams Fusion Method for the Oxygen Evolution Reaction
Authors: Felix Cecil , Bladergroen Bernard J. , Linkov Vladimir , Pollet Bruno G. , Pasupathi Sivakumar
Published: April 2019

The development of highly stable and active electrocatalysts for the oxygen evolution reaction (OER) has attracted significant research interest. IrO2 is known to show good stability during the OER however it is not known to be the most active. Thus, significant research has been dedicated to enhance the activity of IrO2 toward the OER. In this study, IrO2 catalysts were synthesized using a modified Adams fusion method. The Adams fusion method is simple and is shown to directly produce nano-sized metal oxides. The effect of the Ir precursor salt to the NaNO3 ratio and the fusion temperature on the OER activity of the synthesized IrO2 electrocatalysts, was investigated. The OER activity and durability of the IrO2 electrocatalysts were evaluated ex-situ via cyclic voltammetry (CV), chronopotentiometry (CP), electrochemical impedance spectroscopy (EIS) and linear sweep voltammetry (LSV). Physical properties of the IrO2 electrocatalysts were evaluated via X-ray diffraction (XRD), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), differential thermal analysis (DTA), and energy dispersive spectroscopy (EDS). The results show that the addition of excess NaNO3 during the modified Adams fusion reaction is not a requirement and that higher synthesis temperatures results in IrO2 electrocatalysts with larger particle sizes and reduced electrocatalytic activity.
Heteropolyacid Salt Catalysts for Methanol Conversion to Hydrocarbons and Dimethyl Ether: Effect of Reaction Temperature
Authors: Yu Yuehong , Sun Daoming , Wang Shuanjin , Xiao Min , Sun Luyi , Meng Yuezhong
Published: April 2019

Phosphotungstic and silicotungstic acid salt catalysts (CuPW, CuSiW, FePW, FeSiW) were synthesized by substitution of protons with ferric and copper ions through a simple replacement reaction. The structure and thermal stability were characterized by IR, XRD and TG, and the salts showed a keggin structure and a thermal tolerance near 450 °C. Temperature programmed reactions indicated that the four catalysts showed similar trends in the change of methanol conversion, DME selectivity, and light olefins selectivity at 100–400 °C. Copper salt catalysts showed a 100% DME selectivity at temperatures ranging from 100–250 °C, while FeSiW and FePW catalysts had a 100% DME selectivity near 250 °C. Moreover, the heteropolyacid salt catalysts also produced a certain number of light olefins at the temperature ranging from 250–350 °C, and the CuSiW catalyst exhibited the highest ethylene and propylene selectivity of 44%. In the stability test evaluated at 200 °C, the catalysts showed different tendencies during the induction period and the same trends during the reduction period for the methanol conversion to DME, due to the differences in the strengths of the strong acid sites. Finally, the silicotungstic acid salt catalysts showed the longest lifetime of 120 h, much longer than the heteropolyacids. This approach provides an effective way to synthesize hydrocarbons through methanol, especially DME, at different temperatures using one catalyst.
Tetracopper(II) Cores Driven by an Unexplored Trifunctional Aminoalcohol Sulfonic Acid for Mild Catalytic C–H Functionalization of Alkanes
Authors: Costa Inês F. M. , Kirillova Marina V. , André Vânia , Fernandes Tiago A. , Kirillov Alexander M.
Published: April 2019

Three new tetracopper(II) coordination compounds were easily generated from Cu(NO3)2, a trifunctional aminoalcohol sulfonic acid (H3bes, N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid) as a principal building block, and a benzene carboxylic acid as a supporting ligand (i.e., benzoic (Hba), 4-hydroxybenzoic (Hfba), or 3-hydroxybenzoic (Hthba) acid). The obtained microcrystalline products, [Cu4(µ-Hbes)3(µ-H2bes)(µ-L)]·2H2O (L = ba− (1), fhba− (2), and thba− (3)), were fully characterized by FTIR (Fourier-transform infrared spectroscopy), elemental analysis, ESI-MS (Electrospray Ionisation Mass Spectrometry), and single-crystal X-ray diffraction methods. Compounds 1–3 were applied as effective homogeneous catalysts in the oxidative C−H functionalization of alkanes (cycloalkanes and propane). Two different model reactions were explored: (1) mild oxidation of alkanes with hydrogen peroxide to give alcohols and ketones, and (2) mild carboxylation of alkanes with carbon monoxide, water, and potassium peroxodisulfate to give carboxylic acids. For these reactions, effects of different parameters, as well as mechanistic and selectivity characteristics, were studied.
Regulation Is in the Air: The Relationship between Hypoxia and Epigenetics in Cancer
Authors: Camuzi Diego , de Amorim Ísis Salviano Soares , Ribeiro Pinto Luis Felipe , Oliveira Trivilin Leonardo , Mencalha André Luiz , Soares Lima Sheila Coelho
Published: April 2019

Hypoxia is an inherent condition of tumors and contributes to cancer development and progression. Hypoxia-inducible factors (HIFs) are the major transcription factors involved in response to low O2 levels, orchestrating the expression of hundreds of genes involved in cancer hallmarks’ acquisition and modulation of epigenetic mechanisms. Epigenetics refers to inheritable mechanisms responsible for regulating gene expression, including genes involved in the hypoxia response, without altering the sequence of DNA bases. The main epigenetic mechanisms are DNA methylation, non-coding RNAs, and histone modifications. These mechanisms are highly influenced by cell microenvironment, such as O2 levels. The balance and interaction between these pathways is essential for homeostasis and is directly linked to cellular metabolism. Some of the major players in the regulation of HIFs, such as prolyl hydroxylases, DNA methylation regulators, and histone modifiers require oxygen as a substrate, or have metabolic intermediates as cofactors, whose levels are altered during hypoxia. Furthermore, during pathological hypoxia, HIFs’ targets as well as alterations in epigenetic patterns impact several pathways linked to tumorigenesis, such as proliferation and apoptosis, among other hallmarks. Therefore, this review aims to elucidate the intricate relationship between hypoxia and epigenetic mechanisms, and its crucial impact on the acquisition of cancer hallmarks.
Improved Synthesis of ZnO Nanowalls: Effects of Chemical Bath Deposition Time and Annealing Temperature
Authors: Pellegrino Domenico , Franzò Giorgia , Strano Vincenzina , Mirabella Salvo , Bruno Elena
Published: April 2019

Zinc Oxide (ZnO) nanowalls (NWLs) are interesting nanostructures for sensing application. In order to push towards the realization of room-temperature operating sensors, a detailed investigation of the synthesis effect on the electrical and optical properties is needed. This work focuses on the low-cost synthesis of ZnO NWLs by means of chemical bath deposition (growth time of 5, 60, and 120 min) followed by annealing in inert ambient (temperature of 100, 200, and 300 °C). The as-grown NWLs show a typical intertwined network of vertical sheets whose features (thickness and height) stabilize after 60 min growth. During thermal annealing, NWLs are converted into ZnO. The electric transport across the ZnO NWL network radically changes after annealing. A higher resistivity was observed for longer deposition times and for higher annealing temperatures, at which the photoluminescence spectra resemble those obtained for ZnO material. A longer deposition time allows for a better transformation to ZnO during the annealing, thanks to the presence of ZnO seeds just after the growth. These findings can have a significant role in promoting the realization of room-temperature operating sensors based on ZnO NWLs.
Climate-Smart Agriculture and Non-Agricultural Livelihood Transformation
Authors: Hellin Jon , Fisher Eleanor
Published: April 2019

Agricultural researchers have developed a number of agricultural technologies and practices, known collectively as climate-smart agriculture (CSA), as part of climate change adaptation and mitigation efforts. Development practitioners invest in scaling these to have a wider impact. We use the example of the Western Highlands in Guatemala to illustrate how a focus on the number of farmers adopting CSA can foster a tendency to homogenize farmers, instead of recognizing differentiation within farming populations. Poverty is endemic in the Western Highlands, and inequitable land distribution means that farmers have, on average, access to 0.06 ha per person. For many farmers, agriculture per se does not represent a pathway out of poverty, and they are increasingly reliant on non-agricultural income sources. Ineffective targeting of CSA, hence, ignores small-scale farming households’ different capacities for livelihood transformation, which are linked to the opportunities and constraints afforded by different livelihood pathways, agricultural and non-agricultural. Climate-smart interventions will often require a broader and more radical agenda that includes supporting farm households’ ability to build non-agricultural-based livelihoods. Climate risk management options that include livelihood transformation of both agricultural and non-agricultural livelihoods will require concerted cross-disciplinary research and development that encompasses a broader set of disciplines than has tended to be the case to date within the context of CSA.
Longevity of Enhanced Geothermal Systems with Brine Circulation in Hydraulically Fractured Hydrocarbon Wells
Authors: Zuo Lihua , Weijermars Ruud
Published: April 2019

A simple, semi-analytical heat extraction model is presented for hydraulically fractured dry reservoirs containing two subparallel horizontal wells, connected by a horizontal fracture channel, using injected brine as the working fluid. Heat equations are used to quantify the heat conduction between fracture walls and circulating brine. The brine temperature profiles are calculated for different combinations of fracture widths, working fluid circulation rates, and initial fracture wall temperatures. The longevity of the geothermal heat extraction process is assessed for a range of working fluid injection rates. Importantly, dry geothermal reservoirs will not recharge heat by the geothermal flux on the time scale of any commercial heat extraction project. A production plan is proposed, with periodic brine circulation maintained in a diurnal schedule with 8 h active production alternating with 16 h of pump switched off. A quasi-steady state is achieved after both the brine temperature and rock temperature converge to a limit state allowing fracture-wall reheating by conduction from the rock interior in the diurnal production schedule. The results of this study could serve as a fast tool for assisting the planning phase of geothermal reservoir design as well as for operational monitoring and management.
On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses
Authors: Lerat Emmanuelle , Casacuberta Josep , Chaparro Cristian , Vieira Cristina
Published: April 2019

Eukaryotic genomes comprise a large proportion of repeated sequences, an important fraction of which are transposable elements (TEs). TEs are mobile elements that have a significant impact on genome evolution and on gene functioning. Although some TE insertions could provide adaptive advantages to species, transposition is a highly mutagenic event that has to be tightly controlled to ensure its viability. Genomes have evolved sophisticated mechanisms to control TE activity, the most important being epigenetic silencing. However, the epigenetic control of TEs can also affect genes located nearby that can become epigenetically regulated. It has been proposed that the combination of TE mobilization and the induced changes in the epigenetic landscape could allow a rapid phenotypic adaptation to global environmental changes. In this review, we argue the crucial need to take into account the repeated part of genomes when studying the global impact of epigenetic modifications on an organism. We emphasize more particularly why it is important to carefully consider TEs and what bioinformatic tools can be used to do so.
Bacterial Aspartyl-tRNA Synthetase Has Glutamyl-tRNA Synthetase Activity
Authors: Rathnayake Udumbara M. , Hendrickson Tamara L.
Published: April 2019

The aminoacyl-tRNA synthetases (aaRSs) are well established as the translators of the genetic code, because their products, the aminoacyl-tRNAs, read codons to translate messenger RNAs into proteins. Consequently, deleterious errors by the aaRSs can be transferred into the proteome via misacylated tRNAs. Nevertheless, many microorganisms use an indirect pathway to produce Asn-tRNAAsn via Asp-tRNAAsn. This intermediate is produced by a non-discriminating aspartyl-tRNA synthetase (ND-AspRS) that has retained its ability to also generate Asp-tRNAAsp. Here we report the discovery that ND-AspRS and its discriminating counterpart, AspRS, are also capable of specifically producing Glu-tRNAGlu, without producing misacylated tRNAs like Glu-tRNAAsn, Glu-tRNAAsp, or Asp-tRNAGlu, thus maintaining the fidelity of the genetic code. Consequently, bacterial AspRSs have glutamyl-tRNA synthetase-like activity that does not contaminate the proteome via amino acid misincorporation.
Citizens’ Juries: When Older Adults Deliberate on the Benefits and Risks of Smart Health and Smart Homes
Authors: Chadborn Neil H. , Blair Krista , Creswick Helen , Hughes Nancy , Dowthwaite Liz , Adenekan Oluwafunmilade , Pérez Vallejos Elvira
Published: April 2019

Background: Technology-enabled healthcare or smart health has provided a wealth of products and services to enable older people to monitor and manage their own health conditions at home, thereby maintaining independence, whilst also reducing healthcare costs. However, despite the growing ubiquity of smart health, innovations are often technically driven, and the older user does not often have input into design. The purpose of the current study was to facilitate a debate about the positive and negative perceptions and attitudes towards digital health technologies. Methods: We conducted citizens’ juries to enable a deliberative inquiry into the benefits and risks of smart health technologies and systems. Transcriptions of group discussions were interpreted from a perspective of life-worlds versus systems-worlds. Results: Twenty-three participants of diverse demographics contributed to the debate. Views of older people were felt to be frequently ignored by organisations implementing systems and technologies. Participants demonstrated diverse levels of digital literacy and a range of concerns about misuse of technology. Conclusion: Our interpretation contrasted the life-world of experiences, hopes, and fears with the systems-world of surveillance, efficiencies, and risks. This interpretation offers new perspectives on involving older people in co-design and governance of smart health and smart homes.
Cardiovascular Disease and the Female Disadvantage
Authors: Woodward Mark
Published: April 2019

Age-standardised rates of cardiovascular disease (CVD) are substantially higher in men than women. This explains why CVD has traditionally been seen as a “man’s problem”. However, CVD is the leading cause of death in women, worldwide, and is one of the most common causes of disability-adjusted life-years lost. In general, this is under-recognised and, in several ways, women are disadvantaged in terms of CVD. Both in primary and secondary prevention, there is evidence that women are undertreated, compared to men. Women often experience heart disease in a different way compared to men, and lack of recognition of this has been shown to have adverse consequences. Female patients of male cardiac physicians have been found to have worse outcomes than their male counterparts, with no such gender differential for female cardiologists. Clinical trials in CVD primarily recruit male patients, yet, it is well recognised that some drugs act differently in women and men. Diabetes and smoking, and perhaps other risk factors, confer a greater proportional excess cardiovascular risk to women than to men, whilst adverse pregnancies and factors concerned with the female reproductive cycle give women added vulnerability to CVD. However, women’s health research is skewed towards mother and child health, an area where, arguably, the greatest public health gains have already been made, and breast cancer. Hence there is a need to redefine what is meant by “women’s health” to encompass the whole lifecycle, with a stronger emphasis on CVD and other non-communicable diseases. Sex-specific analyses of research data should be the norm, whenever feasible.
Exogenous Glycinebetaine Reduces Cadmium Uptake and Mitigates Cadmium Toxicity in Two Tobacco Genotypes Differing in Cadmium Tolerance
Authors: He Xiaoyan , Richmond Marvin E.A. , Williams Darron V. , Zheng Weite , Wu Feibo
Published: April 2019

Greenhouse hydroponic experiments were conducted using Cd-sensitive (cv. Guiyan1) and Cd-tolerant (cv. Yunyan2) tobacco cultivars to study the ameliorative effects of exogenous glycinebetaine (GB) upon 5 μM Cd stress. The foliar spray of GB markedly reduced Cd concentrations in plants and alleviated Cd-induced soil plant analysis development (SPAD) value, plant height and root length inhibition, with the mitigation effect being more obvious in Yunyan2. External GB markedly reduced Cd-induced malondialdehyde (MDA) accumulation, induced stomatal closure, ameliorated Cd-induced damages on leaf/root ultrastructure, and increased the chlorophyll content and fluorescence parameters of Fo, Fm, and Fv/Fm in both cultivars and Pn in Yunyan2. Exogenous GB counteracted Cd-induced alterations of certain antioxidant enzymes and nutrients uptake, e.g., the depressed Cd-induced increase of superoxide dismutase (SOD) and peroxidase (POD) activities, but significantly elevated the depressed catalase (CAT) and ascorbate peroxidase (APX) activities. The results indicate that alleviated Cd toxicity by GB application is related to the reduced Cd uptake and MDA accumulation, balanced nutrients and antioxidant enzyme activities, improved PSII, and integrated ultrastructure in tobacco plants.
Youla–Kučera Parametrization with no Coprime Factorization—Single-Input Single-Output Case
Authors: Mori Kazuyoshi
Published: April 2019

We present a generalization of the Youla—Kučera parametrization to obtain all stabilizing controllers for single-input and single-output plants. This uses three parameters and can be applied to plants that may not admit coprime factorizations. In this generalization, at most two rational expressions of plants are required, while the Youla–Kučera parametrization requires precisely one rational expression.
Stabilization of Supramolecular Networks of Polyiodides with Protonated Small Tetra-azacyclophanes
Authors: Savastano Matteo , Martínez-Camarena Álvaro , Bazzicalupi Carla , Delgado-Pinar Estefanía , Llinares José M. , Mariani Palma , Verdejo Begoña , García-España Enrique , Bianchi Antonio
Published: April 2019

Polyiodide chemistry is among the first historically reported examples of supramolecular forces at work. To date, owing to the increasingly recognized role of halogen bonding and the incorporation of iodine-based components in several devices, it remains an active field of theoretical and applied research. Herein we re-examine azacyclophanes as a class of ligands for the stabilization of iodine-dense three-dimensional networks, showing how we devised novel possible strategies starting from literature material. The new set of azacyclophane ligands affords novel crystal structures possessing intriguing properties, which develop on a double layer. At a macroscopic level, the obtained networks possess a very high iodine packing density (less than 2 times more diluted than crystalline I2): a simple parameter, IN, is also introduced to quickly measure and compare iodine packing density in different crystals. On the microscopic level, the present study provides evidence about the ability of one of the ligands to act as a three-dimensional supramolecular mold for the template synthesis of the rarely observed heptaiodide (I7−) anion. Therefore, we believe our approach and strategy might be relevant for crystal engineering purposes.
Commercially Available Essential Oil Formulas as Repellents Against the Stored-Product Pest Alphitobius diaperinus
Authors: Francikowski Jacek , Baran Bartosz , Cup Mikołaj , Janiec Jakub , Krzyżowski Michał
Published: April 2019

The main aim of the presented paper is to assess the potential repellent effect of selected essential oils (EOs) against the lesser mealworm (Alphitobius diaperinus), which can cause economic losses in storage and in the poultry industry. Due to the development of pesticide resistance in A. diaperinus populations, as well as an attempt to limit extensive use of potentially harmful pesticides in food-related industries, there is a strong need for the development of alternative methods of dealing with A. diaperinus infestations. Because of their cost-effectiveness, availability and low vertebrate toxicity, EOs are promising agents in pest management. In the presented paper four off-the-shelf EOs: mint, vanilla, lemon and citronella (and mixtures of them) were tested as potential repellents. Moreover, a novel preference assay, providing an extended analysis of the preference and the locomotor response, was used. The most effective EOs were: citronella and lemon. EOs mixtures were generally more repellent than individual EOs, with the lemon and vanilla 1:1 mixture acting as the strongest repellent. A few of the tested EOs caused significant alterations to the locomotor activity, although no direct relation was observed. In conclusion, EOs can be potentially used as repellent agents in A. diaperinus management. Additionally, data on the locomotor activity may lead to designing better push-pull strategies in pest management.
PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers
Authors: Keung Man , Wu Yanyuan , Vadgama Jaydutt
Published: April 2019

Poly (ADP-ribose) polymerases (PARPs) play an important role in various cellular processes, such as replication, recombination, chromatin remodeling, and DNA repair. Emphasizing PARP’s role in facilitating DNA repair, the PARP pathway has been a target for cancer researchers in developing compounds which selectively target cancer cells and increase sensitivity of cancer cells to other anticancer agents, but which also leave normal cells unaffected. Since certain tumors (BRCA1/2 mutants) have deficient homologous recombination repair pathways, they depend on PARP-mediated base excision repair for survival. Thus, inhibition of PARP is a promising strategy to selectively kill cancer cells by inactivating complementary DNA repair pathways. Although PARP inhibitor therapy has predominantly targeted BRCA-mutated cancers, this review also highlights the growing conversation around PARP inhibitor treatment for non-BRCA-mutant tumors, those which exhibit BRCAness and homologous recombination deficiency. We provide an update on the field’s progress by considering PARP inhibitor mechanisms, predictive biomarkers, and clinical trials of PARP inhibitors in development. Bringing light to these findings would provide a basis for expanding the use of PARP inhibitors beyond BRCA-mutant breast tumors.
Predictive Factors and Oncologic Outcome of Downgrade to Pathologic Gleason Score 6–7 after Radical Prostatectomy in Patients with Biopsy Gleason Score 8–10
Authors: Chung Doo Yong , Lee Jong Soo , Goh Hyeok Jun , Koh Dong Hoon , Kim Min Seok , Jang Won Sik , Choi Young Deuk
Published: April 2019

Gleason score (GS) 8–10 is associated with adverse outcomes in prostate cancer (PCa). However, biopsy GS (bGS) may be upgraded or downgraded post-radical prostatectomy (RP). We aimed to investigate predictive factors and oncologic outcomes of downgrade to pathologic GS (pGS) 6–7 after RP in PCa patients with bGSs 8–10. We retrospectively reviewed clinical data of patients with bGS ≥ 8 undergoing RP. pGS downgrade was defined as a pGS ≤ 7 from bGS ≥ 8 post-RP. Univariate and multivariate cox regression analysis, logistic regression analysis, and Kaplan–Meier curves were used to analyze pGS downgrade and biochemical recurrence (BCR). Of 860 patients, 623 and 237 had bGS 8 and bGS ≥ 9, respectively. Post-RP, 332 patients were downgraded to pGS ≤ 7; of these, 284 and 48 had bGS 8 and bGS ≥ 9, respectively. Prostate-specific antigen (PSA) levels; clinical stage; and adverse pathologic features such as extracapsular extension, seminal vesicle invasion and positive surgical margin were significantly different between patients with pGS ≤ 7 and pGS ≥ 8. Furthermore, bGS 8 (odds ratio (OR): 0.349, p < 0.001), PSA level < 10 ng/mL (OR: 0.634, p = 0.004), and ≤cT3a (OR: 0.400, p < 0.001) were identified as significant predictors of pGS downgrade. pGS downgrade was a significant positive predictor of BCR following RP in patients with high bGS (vs. pGS 8, hazard radio (HR): 1.699, p < 0.001; vs. pGS ≥ 9, HR: 1.765, p < 0.001). In addition, the 5-year BCR-free survival rate in patients with pGS downgrade significantly differed from that in patients with bGS 8 and ≥ 9 (52.9% vs. 40.7%, p < 0.001). Among patients with bGS ≥ 8, those with bGS 8, PSA level < 10 ng/mL, and ≤cT3a may achieve pGS downgrade after RP. These patients may have fewer adverse pathologic features and show a favorable prognosis; thus we suggest that active treatment is needed in these patients. In addition, patients with high-grade bGS should be managed aggressively, even if they show pGS downgrade.
Development of an Elastic Material Model for BCC Lattice Cell Structures Using Finite Element Analysis and Neural Networks Approaches
Authors: Alwattar Tahseen A. , Mian Ahsan
Published: April 2019

Lattice cell structures (LCS) are being investigated for applications in sandwich composites. To obtain an optimized design, finite element analysis (FEA) -based computational approach can be used for detailed analyses of such structures, sometime at full scale. However, developing a large-scale model for a lattice-based structure is computationally expensive. If an equivalent solid FEA model can be developed using the equivalent solid mechanical properties of a lattice structure, the computational time will be greatly reduced. The main idea of this research is to develop a material model which is equivalent to the mechanical response of a lattice structure. In this study, the mechanical behavior of a body centered cubic (BCC) configuration under compression and within elastic limit is considered. First, the FEA approach and theoretical calculations are used on a single unit cell BCC for several cases (different strut diameters and cell sizes) to predict equivalent solid properties. The results are then used to develop a neural network (NN) model so that the equivalent solid properties of a BCC lattice of any configuration can be predicted. The input data of NN are bulk material properties and output data are equivalent solid mechanical properties. Two separate FEA models are then developed for samples under compression: one with 5 × 5 × 4 cell BCC and one completely solid with equivalent solid properties obtained from NN. In addition, 5 × 5 × 4 cell BCC LCS specimens are fabricated on a Fused Deposition Modeling uPrint SEplus 3D printer using Acrylonitrile Butadiene Styrene (ABS) and tested under compression. Experimental load-displacement behavior and the results obtained from both the FEA models are in good agreement within the elastic limit.
Ship Manoeuvrability-Based Simulation for Ship Navigation in Collision Situations
Authors: Ni Shengke , Liu Zhengjiang , Cai Yao
Published: April 2019

In this article, a ship manoeuvrability-based simulation for ship navigation in collision situations is established. Under the general requirement from the Convention on the International Regulations for Preventing Collisions at Sea (COLREGs) and good seamanship, the determination of encounter situations is quantified to reduce navigators’ intervention. Meanwhile, the action manner by course alteration or changing speed in some typical encounter situations is graphically analysed for both the give-way and stand-on vessels. Then, the multiple genetic algorithm and linear extension algorithm are adopted to perform trajectory planning for collision avoidance. To improve the reliability of the simulation system, the mathematical model of ship motion and ship manoeuvring control mechanism are adopted, which can eliminate the insufficiency of neglect of ship manoeuvrability in the process of collision avoidance. Meanwhile, the course encoding technique is adopted to fit the ship manoeuvring control mechanism. Finally, a set of traffic scenarios emulating different encounter situations are applied to demonstrate the effectiveness, consistency, and practicality of this system.
Announcing the 2019 JMSE Travel Awards for Postdoctoral Researchers and Ph.D. Students
Authors: Clare Anthony S.
Published: April 2019

Following the successful launch of the JMSE travel awards last year, this year’s competition attracted over 40 applications [...]
Candida albicans and non-albicans Isolates from Bloodstream Have Different Capacities to Induce Neutrophil Extracellular Traps
Authors: Campos-Garcia Lizbeth , Jimenez-Valdes Rocio Jimena , Hernandez-Bello Romel , Palma-Nicolas Jose , Gonzalez Gloria Maria , Sanchez-Gonzalez Alejandro
Published: April 2019

Neutrophils activated with pathogens or their products induce formation of extracellular traps (NETs), but if this constitutes a general response against all pathogenic species in a single genus or intrageneric differences exist remains unknown, yet this is of great importance for the establishment of effective treatments. To determine this, we analyzed neutrophil extracellular traps formation after the stimulation with bloodstream isolates from different Candida species (Candida albicans, C. tropicalis, C. parapsilosis, and C. glabrata), and found that each species has a different capacity to induce DNA extrusion, which is independent of their morphology (yeast or hyphae). We observed that phospholipase producer’s strains and their secretion products were able to induce NETs, a property not observed with phospholipase deficient strains, with exception of some Candida glabrata sensu stricto isolates, which showed no NETs induction although they did show phospholipase production. To further analyze this, we extended our study to include Candida glabrata cryptic species (C. bracarensis and C. nivariensis) and no extracellular traps formation was observed. Here, we contribute to the understanding of how neutrophils initiate NETs, and we found that certain strains may have a differential capacity to trigger these structures, which may explain the high mortality of some isolates.
Sentiment-Induced Bubbles in the Cryptocurrency Market
Authors: Chen Cathy Yi-Hsuan , Hafner Christian M.
Published: April 2019

Cryptocurrencies lack clear measures of fundamental values and are often associated with speculative bubbles. This paper introduces a new way of testing for speculative bubbles based on StockTwits sentiment, which is used as the transition variable in a smooth transition autoregression. The model allows for conditional heteroskedasticity and fat tails of the conditional distribution of the error term, and volatility may depend on the constructed sentiment index. We apply the model to the CRIX index, for which several bubble periods are identified. The detected locally explosive price dynamics, given the specified bubble regime controlled by a smooth transition function, are more akin to the notion of speculative bubble that is driven by exuberant sentiment. Furthermore, we find that volatility increases as the sentiment index decreases, which is analogous to the commonly called leverage effect.
Evidence of Photo-Thermal Effects on the First-Order Thermo-Induced Spin Transition of [{Fe(NCSe)(py)2}2(m-bpypz)] Spin-Crossover Material
Authors: Boukheddaden Kamel , Fourati Houcem , Singh Yogendra , Chastanet Guillaume
Published: April 2019

We have investigated by means of optical microscopy and magnetic measurements the first-order thermal spin transition of the [{Fe(NCSe)(py)2}2(m-bpypz)] spin-crossover compound under various shining intensities, far from the light-induced spin-state trapping region. We found evidence of photo-heating effects on the thermally-induced hysteretic response of this spin-crossover material, thus causing the shift of the thermal hysteresis to lower temperature regions. The experimental results are discussed in terms of the apparent crystal temperature and are analyzed theoretically using two evolution equations of motion, written on the high-spin (HS) fraction and heat balance between the crystal and the thermal bath. A very good qualitative agreement was found between experiment and theory in the stationary regime, explaining the experimental observations well and identifying the key factors governing these photo-thermal effects.