bluuebunny/crossref_metadata_2025 huggingface dataset:
Higher drawing depth and less wrinkling due to drawbeads in paperboard forming
Authors: Jessen Nicola , Groche Peter
Published: December 2024

Deep drawing of paperboard has shown promising results for the packaging industry due to its high productivity, economical process routes, and geometrical freedom. Paper, as a material, offers a combination of compostability and recyclability while consisting of renewable resources. However, formed paper can exhibit wrinkles due to the excess material during the deep drawing process. Wrinkles form differently depending on the anisotropic behavior caused by fiber orientations. To control material deformation while forming asymmetric components the sheet metal industry uses draw beads. This paper investigates the impact of draw beads on paperboard forming. The goal is to avoid additional process steps while increasing the achievable drawing depth as well as the wrinkle control. The design of the draw beads, including their advantages and disadvantages, is discussed based on experimental tests and compared with numerical simulations. Results show that while draw beads increase drawing depth and reduce wrinkles, their position and length affect the severity and distribution of wrinkles, as well as the wrinkle-free distance.
Israeli Demonstration Posters: Spatial Semiotics of Silence
Authors: Ornan-Ephratt Michal
Published: December 2024

Israel’s coalition effort (2023) to introduce a “(judicial) reform” was perceived by many Israelis as endangering Israel’s standing as a democratic state. The salience of silence as a theme and a form in the posters exhibited in the demonstrations supporting and opposing the coalition’s move triggered the examination of the semiotic roles played by silence in those posters and whether this use of silence differed by reform support/opposition. Two-hundred and twenty posters partaking in the demonstrations’ linguistic landscape were examined. Implementing an algorithm based on Ephratt’s (2022) model for identifying different types of silences revealed that fifty six of the posters alluded to one of the six categories of silence (stillness, symptomatic silences, silencing, pauses, the unsaid or verbal silence). These posters served as the data for a qualitative-thematic methodology, iteratively abstracting semiotic roles. Silences and silencing reoccurred as a theme concerning political discourse, particularly the matter of voice. The need for parsimonious use of crucial signantia on posters transformed into a semiotic strategy in which leaving out expected signantia served iconically to communicate absence, conatively activate the observers or express consent, metalinguistically convey the shortage of words, legally circumvent possible charges and create a hiatus that provides soothing qualities, enhancing in-group and out-group tolerance. The differing use of silence in the posters, depending on reform support/opposition, is explained in terms of horror vacui and motivation. Finally, the individual posters, as material texts, did not appear nor function in isolation: they took an active part in producing the demonstrations’ spatial semiotics.
EXPRESSION OF IMMUNOGLOBULIN LIGHT CHAIN GENES IN STEREOTYPED CASES FROM UKRAINIAN COHORT OF CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS
Authors: ABRAMENKO I. , BILOUS N. , MARTINA Z. , DYAGIL I. , CHUMAK A.
Published: December 2024

Background. Analysis of immunoglobulin heavy chain gene (IGHV) rearrangements expressed in chronic lymphocytic leukemia (CLL) cells has provided insights into the B-cell receptor (BCR) repertoire in CLL. In more than 40% of CLL patients, (quasi)identical or stereotyped BCR is expressed. The recent data point at the non-stochastic expression of immunoglobulin light lambda (IGLV) or kappa (IGKV) chains as well. Several pairs of IGHV and IGK/LV have been described for some major stereotyped subsets, but most subsets have not been characterized. Aim. To study the IGK/LV gene expression in stereotyped CLL cases. Materials and Methods. Analysis was performed in a group of 105 CLL patients with stereotyped BCR. The cases with stereotyped BCRs were identified according to Agathangelidis et al. (2021). The IGHV and IGK/LV gene expressions were studied by a polymerase chain reaction followed by direct sequencing. Results. The expression of the IGK/LV genes in the most presented major stereotyped subsets (#1, #2, #3C3, #4, #6, #28а) was in agreement with the data reported by other authors. For the cases of subsets #5b, #9D1, #9D4, #16, #50, #59, and #77, differences were found. The new data on the IGK/LV gene expression in 55 minor clusters were presented. A number of patterns of the IGK/LV gene expression depending on the phylogenetic clan and mutational status of the IGHV genes have been described. Conclusion. The non-stochastic distribution of the IGKV/LV gene expression in the individual stereotyped subsets was confirmed. Taking into account the complementary role of the light chains in antigen recognition by the clonotypic BCRs, it was suggested that the subsets with the heterogeneous IGK/LV expression might be reclassified and divided into separate subgroups based on the IGHV and IGK/LV association.
IDENTIFICATION OF CLINICALLY RELEVANT GENE VARIANTS IN COLON ADENOCARCINOMA SAMPLES OF UKRAINIAN PATIENTS USING A COMPREHENSIVE CANCER PANEL: A PILOT STUDY
Authors: GERASHCHENKO G. , GULKOVSKYI R. , MELNICHUK N. , HRYSHCHENKO N. , MARCHYSHAK T. , MANKOVSKA O. , BEZVERKHIY A. , KOTUZA I. , ROSHA L. , KOTUZA A. , TKACHUK Z. , KASHUBA V. , TUKALO M.
Published: December 2024

The study aimed to identify the clinically relevant gene variants in colon adenocarcinoma samples of Ukrainian patients using the NGS Comprehensive Cancer Panel (CCP) to implement them conveniently in clinical practice. Methods. We have studied 20 samples of Ukrainian patients with colorectal adenocarcinomas of various differentiation grades. To identify the clinically relevant gene variants, the CCP data were filtered using the Franklin by Genoox database. Results. A total of 79 clinically relevant gene variant alterations (SNVs, INDELs) were found in 28 of 409 genes. The largest number of mutations was found in 3 genes, APC, TP53, and KRAS (16, 14, and 8, accordingly). We revealed 4 variants in PTEN and SMAD4, 3 variants in CHEK2, ERBB2, and PIK3CA genes, and 2 variants in AKT1, ATM, DST, IDH1, and TCF12. Mutations for 7 genes, KRAS, TP53, CHEK2, PTEN, AKT1, APC, and SMAD4, were found in more than 1 tumor tissue sample. Tier 1—2 gene variants rate was about 50% of all genetic variants. The therapeutic significance was found in more than 55% of mutations. Additionally, 11 novel genetic mutations in 9 genes have been identified, including G6PD, APC, DST, SINE1, SMAD2, and FLCN. Conclusions. These data suggest a high level of clinical relevance of the NGS CCP approach. Further confirmation on a larger number of samples and using a deeper analysis by other approaches is required.
SIGNIFICANCE OF miRNA-185-5P AND miRNA-424-5P AS PROGNOSTIC MARKERS IN PROGRESSION OF EARLY-STAGE ENDOMETRIAL CANCER
Authors: IURCHENKO N.P. , GLUSHCHENKO N.M. , NESPRYADKO S.V. , BUCHYNSKA L.G.
Published: December 2024

Aim. To compare the expression of miRNA-185-5p and miRNA-424-5p in tumor cells and peripheral blood serum (PBS) of patients with endometrioid carcinoma of the endometrium (ECE) and to evaluate the significance of these biomarkers in cancer progression. Materials and Methods. The study was conducted on the samples of peripheral blood serum (PBS) and tumor tissue of 58 patients with stage I ECE using clinical and morphological methods and real-time polymerase chain reaction. Results. A significant increase in the levels of circulating and tumor-associated miRNA-424-5p was established in ECE patients with a history of recurrences compared to patients without recurrences. To the contrary, the expression level of miRNA-185-5p increased in the PBS and decreased in the tumor tissue of ECE patients with recurrences compared to the patients without recurrence. In addition, we revealed that the expression levels of the studied miRNAs were associated with the differentiation grade and degree of tumor invasion. We established that miRNA-424-5p levels in PBS could serve as the most significant indicator for predicting the occurrence of recurrence in patients with ECE (AUC = 0.991; Sp 94.0%; Se 99.9%). Conclusions. The expression features of miRNA-185-5p and miRNA-424-5p in the PBS and tumor tissue of patients with ECE are associated with the aggressiveness of cancer course and the risk of recurrence.
An overview of the Bantoid languages
Authors: Blench Roger
Published: December 2024

The Bantoid languages are a body of some 150-200 languages positioned geographically between Nigeria and Cameroun. They do not form a genetic group, but all are in some way related to Bantu more closely than other branches of Benue-Congo. The most well-known branches are Dakoid, Mambiloid, Tivoid, Beboid, Grassfields, and Ekoid. Bendi, formerly Cross River, may be Bantoid, while Jarawan is probably Narrow Bantu. Their classification is controversial. Due to their inaccessibility, many are poorly described. The article summarises the literature on their classification and main linguistic features, and in particular how these relate to Bantu. It also includes a brief survey of endangerment of smaller languages and the state of literacy development.Their main typological characteristics include S (AUX) OV word order, functioning or fossilised nominal affixing and concord (sometimes alliterative), suffixed verbal extensions, ATR vowel harmony and labial-velars in the phonology. Some languages have developed highly complex tone-systems as a result of extreme erosion of segmental material.
Christoph Marx: Von Berlin nach Timbuktu – Der Afrikaforscher Heinrich Barth – Biographie. Göttingen: Wallstein 2021, 381 S., zahlreiche Abb.
Authors: Gerhardt Ludwig
Published: December 2024

Review of Christoph Marx. 2021. Von Berlin nach Timbuktu – Der Afrikaforscher Heinrich Barth – Biographie.
The Power of Belief: Unpacking Religion's Role in Mental Health Outcomes
Authors: Napilah Paridah , Truna Dody S. , Albustomi Ahmad Gibson
Published: December 2024

Every human being has experienced various problems in his life, so it has an impact on his mental health. The purpose of this paper is to look at the extent of the influence of religion on mental health. This paper uses a literature study by looking for information both from books and journals and the latest research related to the theme of discussion. The main sources used in this study are books about God in the human brain. The results of this research show that religion can have an influence on mental health. This is because there is an attitude of surrender to the Most High, namely God. This attitude of surrender causes optimism towards a person so that various positive feelings such as happiness, pleasure, and calm arise when facing various life problems.
Contribution: By synthesizing information from multiple sources about religion's impact on mental health, the article contributes to ongoing discussions in both academic and clinical settings about how best to support individuals facing psychological difficulties through their faith.
Expressing the unexpressed: self-disclosure as interactional achievement in the psychotherapy session
Authors: Pawelczyk Joanna , Erskine Richard
Published: December 2024

Self-disclosure is endemic to psychotherapy. Though clients themselves disclose their experiences and emotionala states during the course of a psychotherapya session, they typically do so with extensive prodding on the part of their therapists. Thus, the therapist's interactional role is an agentive one, facilitating a client's verbalization of therapeutically-relevant material. In this article we will discuss how the therapist manages such facilitation locally when the client (unexpectedly) ceases his/her self-disclosure, often at potentially therapeutically relevant moments. As a locally managed interactional practice, the therapist's intervention resumes the client's self-disclosure. Since such intervention emerges amidst ongoing, emotionally-loaded revelations on the part of the client, they should be interactionally aligned with the client's contribution. This paper describes how the psychotherapist enables the client to verbalize significant aspects of self, aspects that may never before have been verbalized or, if verbalized, failed to elicit any empathetic response from an interested listener. This paper presents how specific communicative strategies and language forms take on therapeutic value in the discussed context, underlining that the communicative function is not pre-ordained but rather remains to be actively constructed in discourse. Data taken from a corpus of audio recordings of actual therapy sessions conducted in August and October, 2004, document the practical application of a Relational Psychotherapy approach based on such categories of methods as, among others, inquiry, attunement, and involvement (Erskine et al. 1999).
Spanish variable direct object marking
Authors: Balasch Sonia
Published: December 2024

In studying the social conditioning of Differential Object Marking (DOM) in Spanish we show a social dimension underlying the variable use of DOM: age of speakers has a moderate but significant effect, with middle-aged speakers showing an increase in overt marking. Previously, the implicit consensus was that there is no sociolectal variation in DOM. To ensure the statistical validity of our results, we developed an original, rigorous, quantitative approach to correct for the unbalanced distribution of the data across factor groups. A problem that has been frequently mentioned in the specialized literature, but never satisfactorily resolved for the linguistic analysis of corpus data.
The role of ultrasound densitometry for screening diagnostics of osteopenia in children with juvenile idiopathic arthritis
Authors: Ilchenko Svitlana , Fialkovska Anastasiia , Makoviichuk Oleksii
Published: December 2024

Juvenile idiopathic arthritis (JIA) in children remains one of the most severe medical and social problems in the world. One of the complications of the disease is the development of osteopenic syndrome (OS) with the possible formation of osteoporosis. Therefore, in the process of monitoring patients with JIA, it is necessary to monitor the structural and functional state of bone tissue.
The aim of the study was to determine the role of ultrasound densitometry (UD) for the screening diagnosis of OS in children with JIA.
Materials and methods: examined 63 children with JIA aged 5 to 18 years. All patients underwent a general clinical examination and determination of the serum content of 25 hydroxyvitamin D (25 (OH) D) and UD to assess the mineral density of bone tissue.
Results. In children with JIA, 41.76 % of cases were diagnosed with OS of various degrees of severity, which corresponds to the results of many studies conducted using such a "gold standard" of diagnosis as dual-energy X-ray absorptiometry (DXA). At the same time, osteopenia I degree was diagnosed in 20.0 % of cases, II degree – in 35.0 % of cases, III degree – in 30.0 % of cases, and in 3 patients (15.0 %) the Z-index was below -2 .5, which meets the criteria for osteoporosis. It was established that children with OS were older than children without this syndrome, significantly more often complained of pain in the joints, morning stiffness and restriction of movements, and during examination, joint deformity was more often detected in them. In addition, children with OS were characterized by a significantly lower level of 25 (OH)D in blood serum (17.3 [14.3, 25.8] vs 28.8 [20.6, 46.3] ng/ml; p< 0.05).
Conclusions. UD can be used for screening diagnosis of OS in children with JIA. The ease of use of ultrasound densitometry devices, the absence of radiation exposure of the child, the possibility of conducting an examination at the bedside, and the low cost are clear advantages of this method of examining bone mineral density compared to DXA
Bacterial plasmids: the role in the development of resistance to antimicrobial compounds
Authors: Koshova Olena , Filimonova Nataliia , Mozghova Larysa , Tishchenko Iryna
Published: December 2024

The rapid increase in the prevalence of multiple drug resistance of pathogenic microorganisms poses a critical threat to public health worldwide, which significantly contributes to the increase in patient mortality and morbidity. Classical agents, used in the past for treatment, are losing their effectiveness, moreover, many of the newer available drugs have already become targets for bacterial resistance mechanisms. As a result, the treatment of infections becomes more complicated, and the total costs of treatment increase.
Purpouse. In this work, we aimed to evaluate the role of plasmids in the development of antibiotic resistance and discuss various mechanisms of bacterial resistance to antibiotics, such as enzymatic inactivation of the antibiotic, reduction of the permeability of the outer cell membrane for the antibiotic, modification of the target mainly due to mutation, active efflux of the drug from the bacterial cell through with the help of enzymatic pumps.
Materials and methods: the search for sources of information was carried out in the databases PubMed, Medline, Web of Science, Google Scholar, as well as electronic repositories of higher education institutions and scientific institutions of Ukraine. Materials related to the research technology of genetic variability and modification of bacteria and mechanisms of resistance of microorganisms to antibiotics were selected.
Results. As a result of evolutionary development, bacteria have acquired two separate genetic systems - chromosomal DNA and extrachromosomal, self-replicating genetic elements called plasmids.
It is bacterial plasmids that play a key role in the diffusion of specific resistance genes, in particular to antibiotics. Plasmids are non-essential parts of bacteria and are double-stranded, circular, or linear DNA molecules capable of autonomous replication, allowing bacteria to adapt to a hostile environment. Today, scientists are most interested in two properties of bacteria, caused by plasmids, - antibiotic resistance and bioremediation. The latter determines the survival and development of bacteria in various adverse conditions, including resistance to pollutants, the ability to decompose different chemical compounds, or adaptation to new ecological niches.
Conclusions. Plasmids carry genes for xenobiotic degradation and heavy metal resistance, making them useful for bioremediation of toxic chemicals in an environmentally safe manner. However, properties, such as antibiotic resistance, result from the excessive and uncontrolled use of these drugs in medicine, veterinary medicine, agriculture, and other fields. Under such conditions, there is a natural selection of those strains of pathogenic bacteria that are carriers of R-plasmids
The impact of greenhouse integrated photovoltaics on Aloe vera cultivation
Authors: KAVGA Angeliki , THOMOPOULOS Vasileios , MANGANI Sylvia , KREMMYDAS Spyros , PETRAKIS Theodoros
Published: December 2024

In recent years, the global demand for medicinal plants has been rising steadily. This study focuses on cultivating Aloe vera within a large-scale, pilot smart greenhouse installed at the University of Patras, Greece. The integration of advanced Internet of Things (IoT) technologies, sensors, and the KYTION cablebot robotic device plays a crucial role in monitoring the cultivation process and deriving valuable insights. The greenhouse structure presented in this study not only recognizes these challenges but actively addresses them through state-of-the-art IoT technology-based measurements. Preliminary quantitative results indicate that cultivating A. vera in greenhouses significantly enhances blooming and production compared to open-field cultivation. This promising approach addresses the growing demand for A. vera specifically and medicinal plants in general. Additionally, it maximizes the use of available arable land, labor, water, and energy, ensuring stable production under unstable and variable climatic conditions. The study aims to control and automate the microclimate, optimizing conditions for A. vera growth within a controlled digital environment. By offering insights into the intersection of smart agricultural practices, technology-driven measurement and automation, and ad-hoc crop-specific cultivation strategies, this research provides a promising pathway for sustainably enhancing A. vera cultivation in controlled environments.
Necesidades sentidas del cuidador familiar del adulto mayor con secuelas post accidente cerebrovascular
Authors: Saucedo Pahua Gerardo , Jiménez González María De Jesús , Moreno González María Mercedes , Duran Badillo Tirso , Morales Álvarez Clara Teresita , Silva Fhon Jack Roberto
Published: December 2024

Objetivo: describir las necesidades sentidas de los cuidadores familiares de adultos mayores que presentan secuelas post accidente cerebrovascular. Método: estudio cualitativo, fenomenológico, mediante entrevistas semiestructuradas individuales, grabadas en audio, con notas en diario de campo, transcritas. Análisis fenomenológico interpretativo a la luz del marco teórico y referencial Edmund Husserl. El estudio sigue las pautas de presentación del Consolidated Criteria for Reporting Qualitative Research. Resultados: Participaron seis, hijas de adultos mayores con secuelas de accidente cerebrovascular, la mayoría eran casadas, con educación secundaria, amas de casa y con bajos ingresos económicos. De sus experiencias de cuidado surgieron tres subtemas; conciencia de la realidad, necesidades sentidas y estrategias de afrontamiento para el cuidado. En ellas, expresan a detalle sus sentimientos e interpretaciones, compartiendo desde sus vivencias los desafíos y cuidados que implica el deterioro de salud de un familiar. Conclusión: las necesidades sentidas identificadas a partir de la experiencia de los cuidadores de familiares incluyen, la necesidad de apoyo para el cuidado. Dentro de esta categoría destacan la preparación para brindar atención en el hogar y el acceso a ayuda psicológica personal.
Beyond scents: fragrance industry partnerships for biodiversity conservation
Authors: F. A. de Paula Luiza , J. Smith Rhian , Handley Vanessa , Antonelli Alexandre , L. Fiedler Peggy
Published: December 2024

Since the 1992 Convention on Biological Diversity at the Earth Summit in Rio de Janeiro, United Nations biodiversity agreements have evolved to provide greater specificity on benefit-sharing and conservation strategies. The Kunming-Montreal Global Biodiversity Framework additionally highlights new opportunities for businesses to support biodiversity conservation, reinforced by the creation of a landmark ‘Cali Fund’ at COP16 in Colombia. However, biodiversity continues to decline at an alarming rate. This paper explores how innovative partnerships between the fragrance industry, conservation NGOs (both global and local), and commercial brands can advance international plant conservation goals. By using the scents of threatened species and ecosystems as inspiration for novel products without destructive harvesting, companies can integrate conservation principles into product development, from sourcing to commercialization, while channeling a portion of proceeds back into conservation efforts. This approach directly connects industries to conservation and addresses a critical gap in plant science expertise within leadership roles in both conservation organizations and businesses. Greater engagement by conservation scientists with the fragrance industry is needed, offering a replicable model for corporate engagement that is sustainable, equitable, and impactful. To achieve these goals, bioprospecting must be reframed to address current environmental, market, and societal challenges.
FIM DO QUALIS E INÍCIO DE UMA NOVA ERA! MUDANÇA RADICAL DA CAPES DANDO VALOR À PESQUISA E NÃO À REVISTA ONDE ELA É PUBLICADA
Authors: Malafaia Osvaldo , Viebig Ricardo Guilherme , Andreollo Nelson Adami
Published: December 2024

Ofício Circular 46/2024-DAV/CAPES de 3 de outubro de 2024 explicita o que já está definido e no que todos os programas de pós-graduação de todas as áreas deverão se adaptar para a avaliação futura do quadriênio 2025/2028. Esta nova visão modifica radicalmente tudo que existiu ao longo das décadas anteriores baseado no Qualis e suas modificações decorridas ao longo do tempo, e que deixou de existir. A metodologia da avaliação vai ser indicada no documento da área, como hoje se faz, mas com indicadores qualitativos e quantitativos diferentes. Eles deverão ser discutidos amplamente não só entre os consultores dos comitês como também com a comunidade acadêmica relacionada à área, podendo ser as associações de classe. Ela agora é chamada de “classificação de artigos”. O que muda é que se deve focar no artigo e não no veículo de publicação. É muito importante entender isso. Classificar artigo é verificar o valor que ele tem ou possa ter para a comunidade ou à ciência onde ele reside. O processo será baseado em três procedimentos de classificação. O primeiro é continuar seguindo equivalência com as bases de cálculo semelhante ao Qualis atual. No segundo - esse sim mudou e muito - a classificação dos artigos deverá ser feita por indicadores bibliométricos diretos do artigo (fator de impacto, índice h, Eingenfactor, Scimago Journal Rank SJR), de citação (frequência com que artigos são citados por outros trabalhos, mostrando a relevância, impacto e qualidade do artigo), altimetria (conjunto de indicadores de comunicação científica da web social que podem avaliar qualidade de revistas e pesquisadores), análises quantitativas diversas das mídias sociais (Instagram, Facebook, Wikipedia e outros), a classificação do artigo por critérios de indexação dos artigos (bases indexadoras), a valorização dos periódicos nacionais com a utilização dos DOIs que permite sua busca pela mídia social, estar em acesso aberto (disponibilização gratuita para o público na internet, sem restrições financeiras e/ou taxas), dentre outros. O terceiro procedimento é a análise qualitativa do artigo, ou seja, a colaboração que o artigo deu para a sociedade de um modo imediato. As revistas brasileiras serão valorizadas através dos seus artigos, mensurados pelo número de citações, indicadores bibliométricos e de mídia social que esse artigo tiver e feito pela mídia nacional e/ou internacional, e não pelo nome da revista aonde foi publicado. Mas, o acesso aberto é fundamental. Entende-se nesse momento que a comunidade científica deve ser ouvida pelos comitês de avaliação das áreas. Diálogos, opiniões e projeções, somente são profícuas com liberdade de expressão e de participação grupal entre todos os atores. Vamos usar este momento para criar algo que venha a nos orgulhar e que possa ser modelo de criação para outros países que pretendam instalar sistemas de pós-graduação em alto nível de confiabilidade, evolução, inovação e de aplicação social.
Oropouche Fever Associated with Combined Central and Peripheral Demyelination (CCPD): A Case Report from Ceará, Brazil, 2024
Authors: Garcia Filho Carlos , Lima Neto Antonio Silva , Maia Ana Maria Cabral , Carvalho Fernanda Martins Maia , Rossi Matheus Andrighetti , Pitombeira Milena Sales , Mato Paula Camila Alves de Assis Pereira , Coelho Tania Mara Silva , Perdigão Neto Lauro Vieira , Almeida Lívia Mendes de , Naveca Felipe Gomes , Luz Kleber Giovanni , Freitas Andre Ricardo Ribas , Cavalcanti Luciano Pamplona de Góes
Published: December 2024

Background: Oropouche fever, caused by the Oropouche orthobunyavirus (OROV), is an arboviral illness transmitted by midges and mosquitoes. Although commonly regarded as a mild illness, severe neurological manifestations are increasingly being reported.
Case Summary: We report a 48-year-old female patient  without comorbidities, from Capistrano, Ceará, Brazil, who developed Combined Central and Peripheral Demyelination (CCPD) following confirmed OROV infection. Her clinical presentation included ascending flaccid tetraparesis, bilateral facial paresis, and progressive visual loss. Neurological investigation confirmed demyelinating polyneuropathy and retrobulbar optic neuritis. Despite initial corticosteroid therapy, gradual and partial clinical improvement was observed after plasmapheresis; however, visual and motor deficits persisted even after 90 days.
Conclusion: A reported case of combined central and peripheral demyelination (CCPD) associated with OROV represents an unprecedented complication, emphasizing the potential for severe outcomes linked to OROV infection. This highlights the need for increased clinical awareness and greater attention to the epidemiology of this disease. OROV infection has demonstrated the capacity to cause severe neuroinvasive complications, underscoring its critical and emerging epidemiological significance amidst the ongoing epidemic in the Americas. Driven by a novel reassortant lineage of OROV, this outbreak has been associated with previously unreported severe manifestations, including adult and fetal deaths. Enhanced surveillance systems and targeted training for the early recognition of neurological complications are essential to mitigate long-term impacts and guide public health strategies to address the growing burden of this arboviral infection.
Detection of covid-19 epidemic waves and their interrelationships in the tri-border region between Brazil, Paraguay, and Argentina, 2020-2023: Covid-19 epidemic waves in the tri-border region
Authors: Luz Larissa D P , Braga Jose Ueleres , Maciel Elvira M G S
Published: December 2024

Introduction: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, was declared a global public health emergency in 2020, profoundly impacting countries around the world. International border regions, such as the tri-border region between Brazil, Paraguay, and Argentina, faced unique challenges, such as high population mobility and the lack of regional integration in controlling the pandemic. Thus, this study aimed to identify and characterize the epidemic waves of COVID-19 in the three health regions of this tri-border region between 2020 and 2023.
Methods: Using secondary epidemiological data, confirmed cases of COVID-19 were analyzed in 9 municipalities in Brazil, 22 in Paraguay, and 13 in Argentina.  Were used to smooth the epidemic curves and identify the waves, their peaks, and valleys based on the EpidemicKabu library, and the cross-correlation statistic function of the epidemic waves in the historical series of the countries.
Results: The study revealed five epidemic waves in total, five in Brazil, five in Paraguay and two in Argentina. The relation between the epidemic waves in Brazil and Paraguay was 0.74 and a lag -1, the correlation between Brazil and Argentina was 0.69 and lag max in 0 and the cross-correlation between Paraguay and Argentina resulted in 0.80 and lag max in 0, a strong correlation was observed of the three regions.
Conclusions: The results highlight the temporal heterogeneity of epidemic waves across the three countries and the importance of cross-border cooperation for infectious disease control. The study reinforces the need for integrated health policies and coordinated epidemiological surveillance in border regions, especially in areas with intense population mobility.
Designing and Delivering Curriculum with Early Industry Exposure Integration: A Model
Authors:   School of ECE, KLE Technological University, Hubballi, India, H M Vijay , Katwe Supriya ,   School of ECE, KLE Technological University, Hubballi, India, Iyer Nalini ,   School of ECE, KLE Technological University, Hubballi, India
Published: December 2024

The university industry's cooperation in curriculum development and delivery has been identified as a key support factor for universities. Hence, universities are looking for an association with the industries that will help them to enhance their translation research and build skill sets, enabling them to work on real-life challenges. Conversely, to remain competitive, industries look for academic collaborations in their research and development activities. To provide students and researchers with good exposure to the industrial environment, courses offering internships in the industry field have proven to be beneficial, and many curriculum development models associated with the industry connect are available in the literature. This paper describes an industry internship program designed for third-year undergraduate engineering students focusing on the Internet of Things (IoT) course. The main objective of this work is to offer students the opportunity to gain familiarity with the industry environment and practical experience, mainly through collaborative teamwork. The study is implemented using a problem-based learning pedagogical approach. The program consists of three primary stages: preparatory training for the internship, the internship duration itself, and the internship projects. The model was successful for the IoT course delivered and assessed in collaboration with the industry personnel. The key outcomes of this industry internship are teamwork, industry readiness, effective communication, and presentation skills.

Keywords—IoT; Industry Internship; Teamwork; Thinkspeak; University- Industry collaborations; PBL
An Arctic Marine Source of Fluorescent Primary Biological Aerosol Particles During the Transition from Summer to Autumn at the North Pole
Authors: Kojoj Julia , Freitas Gabriel Pereira , Muilwijk Morven , Granskog Mats A. , Naakka Tuomas , Ekman Annica M. L. , Heutte Benjamin , Schmale Julia , Da Silva Anderson , Lapere Rémy , Marelle Louis , Thomas Jennie L. , Melsheimer Christian , Murray Benjamin J. , Zieger Paul
Published: December 2024

Studying primary biological aerosol particles in the Arctic is crucial to understanding their role in cloud formation and climate regulation at high latitudes. During the Arctic Ocean 2018 expedition, fluorescent primary biological aerosol particles (fPBAPs) were observed, using a multiparameter bioaerosol spectrometer, near the North Pole during the transition from summer to early fall. The fPBAPs showed a strong correlation with the occurrence of ice nucleating particles (INPs) and had similar concentration levels during the first half of the expedition. This relationship highlights the potential importance of biological sources of INPs in the formation of mixed-phase clouds during the central Arctic’s summer and early fall seasons.
Our analysis shows that the observed fPBAPs were independent of local wind speed and the co-occurrence of other coarse mode particles, suggesting sources other than local sea spray from leads, melt ponds, re-suspension of particles from the surface, or other wind-driven processes within the pack ice. In contrast, other fluorescent particles were correlated with wind speed and coarse mode particle concentration.
A multi-day event of high concentrations of fPBAPs was observed at the North Pole, during which the contribution of fPBAPs to the total concentration of coarse mode aerosol increased dramatically from less than 0.1% up to 55%. Analysis of chemical composition and particle size suggested a marine origin for these fPBAPs, a hypothesis further supported by additional evidence. Air parcel trajectory analysis coupled with ocean productivity reanalysis data, as well as analysis of large-scale meteorological conditions, all linked the high concentrations of fPBAPs to biologically active, ice-free areas of the Arctic Ocean.
Haasteena eriytyvä osaaminen: kahdeksannen luokan oppilaiden matematiikan ja luonnontieteiden osaaminen
Authors: Hiltunen Jenna , Kotila Jenni , Lehtola Piia , Kauppinen Heli , Markkanen Ilona , Nissinen Kari , Puhakka Eija , Pulkkinen Jonna , Vaara Elina , Vettenranta Jouni
Published: December 2024

Julkaisu on TIMSS 2023 -tutkimuksen (Trends in International Mathematics and Science Study) kahdeksannen vuosiluokan ensitulosten kansallinen raportti. Tutkimuksessa tarkastellaan oppilaiden matematiikan ja luonnontieteiden osaamista opetussuunnitelmaperustaisesti. Kahdeksannen vuosiluokan arviointiin osallistui 44 maata tai hallinnollista aluetta. Suomesta tutkimukseen osallistui 5 880 kahdeksannen vuosiluokan oppilasta ja yli 400 matematiikan opetusryhmää 161 koulusta. Suomessa on nyt kolmannen kerran selvitetty kahdeksannen vuosiluokan oppilaiden osaamista kansainvälisesti vertaillen. Vuosien 2023, 2019 ja 2011 tutkimusten tuloksia vertaamalla voidaan tarkastella osaamisessa ja taustamuuttujissa tapahtuneita muutoksia. Raportti antaa katsauksen matematiikan ja luonnontieteiden oppimistuloksiin peruskoulun loppuvaiheessa. Oppimistulosten lisäksi julkaisussa tarkastellaan matematiikan ja luonnontieteiden oppimiseen liittyviä oppilaiden asenteita. Tasa-arvo huomioidaan monesta eri näkökulmasta, kuten tarkastelemalla tyttöjen ja poikien välisiä osaamiseroja, oppilaiden kotitaustan yhteyttä osaamiseen, alueellisia eroja Suomessa sekä koulujen ja luokkien välisiä eroja osaamisessa. Uutena osa-alueena raportissa tarkastellaan oppilaiden ympäristötietoisuutta sekä ympäristönsuojeluun asennoitumista.
On Shilla Graphs Γ With b2=c2 Having Eigenvalue θ2=0
Authors:   School of Science, Hainan University, Makhnev Alexander A. ,   N. N. Krasovskii Institute of Mathematics and Mechanics, Bitkina Victoriya V. ,   North Ossetian State University after K.L. Khetagurov, Gutnova Alina K. ,   North Ossetian State University after K.L. Khetagurov
Published: December 2024

The Shilla graph with b2=c2 and eigenvalue θ2=0 has intersection array {b(b+1)s,(bs+s+1)(b-1),bs;1,bs,(b2-1)s}. There are only seven graphs out of 55 with b<100 do not lie in the series {4s3+6s2+2s,4s3+4s2+2s,2s2+s;1,2s2+s,4s3+4s2}.This paper studies the Shilla graphs with b2=c2, eigenvalue θ2=0 and intersection array {4s3+6s2+2s,4s3+4s2+2s,2s2+s;1,2s2+s,4s3+4s2}.
Gyrostat Dynamics in the Light Field of Semi-Euclidean Space
Authors: Makeev Nikolay N.
Published: December 2024

The motion of a gyrostat in a stationary field of light pressure forces in semi-Euclidean space is investigated. A gyrostat with kinetic axial symmetry and a constant gyrostatic moment moves so that its carrier rotates around the center of inertia. The field of light pressure forces is generated by a stationary light flux of constant intensity, formed by parallel rays of light, and is assumed to be conservative. Based on an improved thermomechanical model of the dynamic interaction of light radiation with a solid surface, a dynamic system is constructed and the limited problem of studying pendulum motion of a special type is considered. Analytical time dependences of the components of the gyrostat angular velocity vector and its orientation parameters are obtained. The parametric equations of the moving hodograph of the gyrostat angular velocity vector and the explicit equation of its bearing surface are found.
Assessment of the effectiveness of technological measures to extend the campaign of blast furnace No. 5 of PJSC Severstal (2006 – 2024) based on an examination of its working space during a first-category overhaul
Authors: Kal’ko A. A. , Leont’ev L. I. , Volkov E. A.
Published: December 2024

The paper presents the findings from the study of the working space of blast furnace No. 5 of PJSC Severstal during its first-category overhaul in 2024 lasting 17.46 years, which significantly exceeded the standard service life. The effectiveness of technological measures taken to extend the furnace’s campaign from 2006 to 2024, aimed at protecting the refractory lining in critical areas such as the hearth, lower shaft, and the upper bosh, was evaluated. The residual thickness of the refractory lining in the shaft, hearth, and metal receiver is analyzed, and maps showing the actual thickness of the lining across different sections are generated. The measured maximum wear of the shaft refractory lining is 344 mm (37.4 % of the original value); the measured maximum wear of carbon blocks in the area of cesspool openings – 313 mm (23.4 % of the original block size). In the upper part of the hearth, the minimum residual thickness of refractories with an Al2O3 content of 43 % is 220 mm or 31.9 % of the initial value. The paper also discusses safe remote measurement methods, including 3D laser scanning of the furnace shaft during the removal of residual charge materials. It highlights the advantages of ground-based laser scanners in capturing dense, high-quality 3D geometric data. Additionally, the paper describes the experience of remotely measuring the residual thickness of carbon blocks around the raking openings. Comparisons are made between the actual residual thickness of the refractory lining in the hearth, bottom carbon blocks, and high-alumina refractories of the tuyere zone, and the results obtained using ultrasonic echo-sounding technology (AU-E) during the furnace’s operation. The paper also includes a description of the stress wave propagation technology, which utilizes data analysis in the time and frequency domains to determine lining thickness and detect anomalies. The results of the current and previous blast furnace campaigns are compared in terms of pig iron production, the number of cooling system failures, and refractory wear across the entire working space of the furnace. The total production of pig iron in the 2006 – 2024 campaign, related to the furnace area, amounted to 420.0 thousand tons/m2 and exceeded the figure for the previous campaign by 1.90 times.
Simulation of structural changes in metal under high-intensity external influence
Authors: Gostevskaya A. N. , Markidonov A. V. , Starostenkov M. D. , Lubyanoi D. A.
Published: December 2024

Today, researchers and industry are faced with the task of improving the physical and mechanical properties of various metal products. To strengthen the structures, there are various technologies for processing the material surface by high-temperature exposure. At the same time, the use of laser technologies is of great interest. High-speed local laser heating of the material surface followed by rapid cooling with heat removal into the volume depth, as well as the absence of mechanical action, allows us to obtain unique nonequilibrium structures with a wide range of properties. Obviously, the development of these technologies requires deep fundamental research. In this work, the molecular dynamics method revealed the features of structural changes in the surface layers of an iron crystal under high-temperature exposure. The choice of such a method is due to the fact that the phenomena under consideration are difficult to study through real experiments and direct observations. Conditions of the computer experiment were set in such a way that after the melting point is reached, a phase transition occurs in the simulated system, during which particles are separated from the surface of the liquid phase. As a result of the study, the threshold temperature of particle ejection was estimated and the mechanisms of particle cluster formation were investigated. When heated, the number of clusters increases, and when cooled, it decreases, but at the same time their sizes increase, which indicates the implementation of the condensation mechanism of ablation products. Additionally, the influence of external pressure on the simulated particle system was studied. It is shown that as the pressure increases, the number of clusters decreases.
Influence of compression modes of waxy powders on stress-strain state of compacts used in precision casting
Authors: Bogdanova N. A. , Zhilin S. G.
Published: December 2024

The high demands placed on the surface quality and geometric complexity of metal products, structures and parts produced from a wide range of non-ferrous and ferrous alloys determine the demand for investment casting as a method that provides a range of critical products for the needs of aircraft, ship building and mechanical engineering industries. A number of “bottlenecks” in the implementation of investment casting processes include a significant number of technological operations, each of them is accompanied by phenomena of a thermophysical nature that require correction, and it ultimately determines the high cost of casting. The difficulties arise from phenomena such as shrinkage of the pattern material, its thermal expansion during melting from a ceramic mold, which determines penetration of pattern mass into ceramic pores and can affect the appea­rance of surface defects, the chemical composition and structure of the alloy of future casting. The process of forming a porous surface on wax patterns without shrinkage defects by pressing powders of waxy materials is aimed at eliminating the noted shortcomings, which ensures the required geometry of the compacts and absence of deformation effects on ceramics of the model material at the stage of its melting. Widespread use of the method is hampered by the lack of information about the features of stress control in the compact body determining the magnitude of elastic response of the compacted material, which is an order of magnitude less than thermal shrinkage. The paper presents the results of an experimental study of influence of the compression rate of powder materials on the stress-strain state of pressed wax patterns formed in a closed matrix, as well as on the strength of these compacts.
Influence of combined thermal effect of electric arc welding with aluminothermic backfill on internal stresses in a steel plate
Authors: Tkacheva A. V. , Abashkin E. E.
Published: December 2024

The paper is devoted to automatic electric arc welding under a flux layer using filler material in the form of aluminothermic backfill for joining thick-plate structures. The plate material is assumed to be elastic-plastic, the deformations are small and consist of elastic and plastic. Reversible (elastic) deformations are associated with stresses by the Duhamel-Neumann law, irreversible (plastic) ones arise and grow due to plastic flow within the framework of the associated law of plastic flow. The modified Mises condition, which takes into account viscosity, is adopted as the condition of plastic flow. The heat source from automatic electric arc welding is modeled by a double ellipsoid proposed by John A. Goldak, and heat from chemical reaction in the region of aluminothermiс combustion front is specified by the heat flux value. Elastic moduli and yield strength depend on temperature. Plates with thicknesses of 12, 14, 16, 18 mm were considered. Comparing the intensity of residual stresses in the upper and lower layers of the plates and by their thicknesses, it can be stated that with increasing thickness, the areas of distribution of residual stresses high intensity increase and their values increase too. These areas are located inside the material in the near-weld zone in the area of blue brittleness. Analyzing straightening of temperature fields, for the case of electric arc welding with filler material in the form of aluminothermiс backfill and without it, it was found that as a result of a chemical reaction, the temperature in the weld zone increases by 500 °C, this makes it possible to use this technology for welding at low climatic temperatures.
Revaloriser la terre crue en Champagne-Ardenne
Authors: ARAS-GAUDRY Adrien , ROUX Dominique , MAIRE Véronique , FRONTEAU Gilles
Published: December 2024

Ce chapitre vise à témoigner d’une démarche de revalorisation d’un matériau à forte valeur écologique sur la base d’une recherche-action, assortie d’une dimension pédagogique, qui a réuni d’une part la chaire IDIS de l’ESAD de Reims, les laboratoires GEGENA et REGARDS de l’URCA, mais également des partenaires variés comme le PNR-MR, des musées, une association locale.