bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of the Effect of Continuous Thermal Effects on the Shear Stability of Magnetorheological Grease
Authors: Li Yiliang , Pan Jiabao , Wang Jin
Published: December 2023

Magnetorheological dampers in the service of the medium in a project experience continuous thermal effects, frequent reciprocating shear and other complex conditions. Shear stability is an important indicator of the reliability of a magnetorheological media service. Magnetorheological grease (MRG) was prepared using hydroxy iron powder with a mass fraction of 30% and lithium grease of different consistency grades as a continuous phase. The results of magnetic and rheological properties analysis were combined to investigate the mechanism of the continuous thermal effect on the shear stability of MRG. The results show that changes in the temperature field and magnetic field cause significant changes in the magnetic and rheological properties of MRG. At low temperatures and low magnetic fields, the soap fiber structure unique to MRG can effectively inhibit the movement of magnetic particles, with slight changes in the rheological properties and excellent shear stability. When the temperature increases to 80 °C, 00#MRG is damaged by the high temperature. The soap fiber structure is fractured and reorganized, and the rheological properties change significantly. However, the rheological properties of 1#MRG remain largely unchanged during the magnetic field enhancement to saturation, showing better shear stability. The higher consistency continuous phase has excellent heat resistance and better shear performance stability in the face of thermomagnetic coupling conditions, but the fiber breakage caused by continuous reciprocating shear poses a challenge to the service stability of MRG.
Investigation of Element Migration from Aluminum Cooking Pots Using ICP-MS
Authors: Ammar Hany R. , Saleh Sayed M. , Sivasankaran Subbarayan , Albadri Abuzar E. A. E. , Al-Mufadi Fahad A.
Published: December 2023

The present study examined the migration of elements from aluminum cooking pots to foods after the cooking process. This study investigated the impact of pot quality (manufacturer), pot type (traditional or pressure cooker), water supply (tap water/mineral water), food acidity, salt, spices, temperature, and cooking time on the migration of elements into cooked food. The cooking experiments were conducted to simulate the actual cooking conditions. Standard food simulant B, with 3% (w/v) acetic acid, was used in subsequent cooking trials to confirm the results. Three methods were employed to analyze the elements in the food: ICP-MS, EDS-SEM, and XPS. The cooking pots used in this investigation were examined using a Spectromaxx metal analyzer to characterize their chemical composition. The concentration of aluminum in cooked food samples increased significantly when using an aluminum pressure cooker. Food acidity, cooking duration, and the type of aluminum pot (traditional/pressure cookers) all affected the concentration of elements that migrated into the food. The aluminum level increased from 80.17 to 133.7 µg/g when tomato sauce was added to the food. Increasing the heating time resulted in an increased aluminum content (157.9 µg/g) in the cooked food. Aluminum pressure cookers exhibited the highest amount of aluminum migration into the food. Foods cooked in a pressure cooker made by manufacturer (3) contained the highest aluminum content (252.7 µg/g), which increased the risk of exceeding the daily intake limit of aluminum. The prepared food samples under all conditions showed a safe health profile for daily intake of all elements (Fe, As, Cd, and Pb), except for Al, which exceeded the daily intake limit when using pressure cookers for extended cooking times. The results of element migration into food simulants were consistent with those of food samples. The results confirmed that SEM-EDS and XPS techniques are not suitable for quantifying the elements that migrated into food samples due to their detection limits.
AICrit: A Design-Enhanced Anomaly Detector and Its Performance Assessment in a Water Treatment Plant
Authors: Raman Gauthama , Mathur Aditya
Published: December 2023

Critical Infrastructure Security Showdown 2021—Online (CISS2021-OL) represented the fifth run of iTrust’s international technology assessment exercise. During this event, researchers and experts from the industry evaluated the performance of technologies designed to detect and mitigate real-time cyber-physical attacks launched against the operational iTrust testbeds and digital twins. Here, we summarize the performance of an anomaly detection mechanism, named AICrit, that was used during the exercise. AICrit utilizes the plant’s design to determine the models to be created using machine learning, and hence is referred to as a “design-enhanced” anomaly detector. The results of the validation in this large-scale exercise reveal that AICrit successfully detected 95.83% of the 27 launched attacks. Our analysis offers valuable insights into AICrit’s efficiency in detecting process anomalies in a water treatment plant under a continuous barrage of cyber-physical attacks.
A Novel Approach for High-Precision Evaluation of Sphericity Errors Using Computational Geometric Method and Differential Evolution Algorithm
Authors: Zhao Dongfang , Cui Junning , Wang Zhisheng , Sun Yanxu
Published: December 2023

The sphericity error is a critical form and position tolerance for spheres. We explored the distribution of sphericity errors within the solution space to achieve a high-precision evaluation using the minimum zone criteria. Within local solution spaces, we propose treating the evaluation of sphericity errors as a unimodal function optimization task. And computational geometric methods are employed to achieve highly accurate solutions within the local solution spaces. Subsequently, we integrated the computational geometric method with the differential evolution algorithm (DE algorithm). By centering on individual population members of the DE algorithm, we partitioned the local solution spaces and utilized the best solutions within them to optimize the population. With the gradual convergence of the DE algorithm, we successfully achieved the high-precision resolution of sphericity errors. The experimental results demonstrate a significant order-of-magnitude improvement in precision compared to traditional algorithms in the field of sphericity error evaluation, with uncertainty levels reaching magnitudes of 10−14 mm. Moreover, this method enhances the accuracy of sphericity error evaluation by approximately 10% for three-coordinate measuring machines. Additionally, we conducted ablation experiments to validate the effectiveness of the proposed computational geometric method. In summary, this approach enables the high-precision evaluation of sphericity errors and provides a practical methodology for applying ultra-precision spheres in precision engineering.
Technical Reviews of Power Loss Optimization in High-Frequency PSiPs—In Relation to Power Switches and Power Inductors
Authors: Wang Yinyu , Zhang Desheng , Lu Liangliang , Huang Baoqiang , Xu Haoran , Min Run , Zou Xuecheng
Published: December 2023

Power losses of switches and inductors are consistent challenges that hinder the development of high-frequency power supply in package (PSiP). This paper investigates the roadmap for power loss optimizations of switches and inductors in high-frequency PSiPs. Firstly, a size and parallel quantity design method to reduce power loss in an integrated Si LDMOSFET is provided with comprehensive consideration of switching frequency and power levels. Secondly, quality factors of different air-core inductors are analyzed with consideration of geometric parameters and skin effect, which provides the winding structure optimization to reduce power losses. The power losses of the integrated Si LDMOSFET and air-core inductors are both reduced to less than 10% of the output power at 1~100 MHz switching frequency and 0.1~10 W power level. Finally, based on the above optimizations, power losses of switches and inductors are calculated with switching frequency and power level. Combining the calculated results, this paper predicts the efficiency boundaries of PSiPs. Upon efficiency normalization with consideration of input and output voltage levels, all the predictions are consistent with the published literature. The efficiency predication error is 1~15% at 1~100 MHz switching frequency and 0.1~10 W power level. The above power loss optimizations improve the efficiency, which provides potential roadmaps for achieving high-frequency PSiPs.
Exploring Electrode Placements to Optimize the Identification and Measurement of Early Auditory Evoked Potentials
Authors: McFarlane Kailyn A. , Sanchez Jason Tait
Published: December 2023

Cochlear synaptic loss (termed cochlear synaptopathy) has been suggested to contribute to suprathreshold hearing difficulties. However, its existence and putative effects in humans remain inconclusive, largely due to the heterogeneous methods used across studies to indirectly evaluate the health of cochlear synapses. There is a need to standardize proxies of cochlear synaptopathy to appropriately compare and interpret findings across studies. Early auditory evoked potentials (AEPs), including the compound action potential (AP)/Wave I of the auditory brainstem response are a popular proxy, yet remain variable based on technical considerations. This study evaluated one such consideration—electrode array (i.e., montage)—to optimize the use of early AEP waveforms. In 35 young adults, electrocochleography (ECochG) responses were collected using vertical and horizontal montages. Standard ECochG measures and AP/Wave I and Wave II peak-to-trough amplitudes and latencies were compared between montages. Vertical montage recordings consistently produced significantly larger AP/Wave I peak-to-trough amplitudes compared to horizontal recordings. These findings support the use of a vertical electrode montage for optimal recordings of peripheral cochlear nerve activity. As cochlear synaptopathy continues to be explored in humans, the methods highlighted here should be considered in the development of a standardized assessment.
Certain Bounds of Formulas in Free Temporal Algebras
Authors: García-Olmedo Francisco Miguel , Rodríguez-Salas Antonio Jesús , González-Rodelas Pedro
Published: December 2023

In this paper, we give a basic structure theorem based on the study of extreme cases for the value of ≺ (the classical precedence relation between ultrafilters), i.e., ≺=∅ and no isolated element in ≺. This gives rise, respectively, to the temporal varieties O and W, with the result that O generates a variety of temporal algebras. We also characterize the simple temporal algebras by means of arithmetical properties related to basical temporal operators; we conclude that the simplicity of the temporal algebra lies in being able to make 0 any element less than 1 by repeated application to it of the L operator. We then present an algebraic construction similar to a product but in which the temporal operations are not defined componentwise. This new “product” is shown to be useful in the study of algebra order and finding of bounds by means of something similar to a lifting process. Finally, we give an alternative proof of an already known result on atoms counting in free temporal algebras.
The Oxygen–Ozone Adjunct Medical Treatment According to the Protocols from the Italian Scientific Society of Oxygen–Ozone Therapy: How Ozone Applications in the Blood Can Influence Clinical Therapy Success via the Modulation of Cell Biology and Immunity
Authors: Chirumbolo Salvatore , Valdenassi Luigi , Tirelli Umberto , Ricevuti Giovanni , Pandolfi Sergio , Vaiano Francesco , Galoforo Antonio , Loprete Fortunato , Simonetti Vincenzo , Chierchia Marianna , Bellardi Debora , Richelmi Tommaso , Franzini Marianno
Published: December 2023

Background. Ozone is an allotrope of oxygen whose use in medicine has rapidly grown in recent years. Ozonated blood allows for the use of ozone in a safe modality, as plasma and blood cells are endowed with an antioxidant system able to quench ozone’s pro-oxidant property and to elicit the Nrf2/Kwap1/ARE pathway. Methods. We present two clinical studies, a case-series (six patients) observational study adopting ozone as a major autohemotherapy and topical ozone to address infected post-surgical wounds with multi-drug resistant bacteria and an observational study (250 patients) using ozonated blood for treating knee osteoarthritis. Results. Ozonated blood via major autohemotherapy reduced the extent of infections in wounds, reduced the inflammatory biomarkers by more than 75% and improved patients’ QoL, whereas ozonated blood via minor autohemotherapy improved significantly (p < 0.001) WOMAC and Lequesne’s parameters in knee osteoarthritis. Conclusions. The models described, i.e., ozone autohemotherapy in wound antimicrobial treatment and ozonated blood in knee osteoarthrosis, following our protocols, share the outstanding ability of ozone to modulate the innate immune response and address bacterial clearance as well as inflammation and pain.
Vagal Stimulation Ameliorates Non-Alcoholic Fatty Liver Disease in Rats
Authors: Elkattawy Hany A. , Mahmoud Samar Mortada , Hassan Ahmed El-Sayed , Behiry Ahmed , Ebrahim Hasnaa Ali , Ibrahim Ateya Megahed , Zaghamir Donia Elsaid Fathi , El-Sherbiny Mohamed , El-Sayed Sherein F.
Published: December 2023

Background: The harmful consequences of non-alcoholic fatty liver disease (NAFLD) are posing an increasing threat to public health as the incidence of diabetes and obesity increases globally. A non-invasive treatment with a range of autonomic and metabolic benefits is transcutaneous vagus nerve stimulation (tVNS). Aim of the study: To investigate the possible preventive impacts of VNS against adult rats’ NAFLD caused by a high-fat diet (HFD) and to clarify the underlying mechanisms. Methods: A total of thirty-two adult male rats were split into two groups: the HFD-induced NAFLD group (n = 24) and the control normal group (n = 8). The obesogenic diet was maintained for 12 weeks to induce hepatic steatosis. The HFD-induced NAFLD group (n = 24) was separated into three groups: the group without treatment (n = 8), the group with sham stimulation (n = 8), and the group with VNS treatment (n = 8). VNS was delivered for 30 min per day for 6 weeks after the establishment of NAFLD using a digital TENS device. The subsequent assessments included hepatic triglyceride, cholesterol content, serum lipid profile, and liver function testing. In this context, inflammatory biomarkers (TNF-α, IL-6) and hepatic oxidative stress (MDA, SOD, and GPx) were also assessed. To clarify the possible mechanisms behind the protective benefits of VNS, additional histological inspection and immunohistochemistry analysis of TNF-α and Caspase-3 were performed. Results: In the NAFLD-affected obese rats, VNS markedly decreased the rats’ body mass index (BMI) and abdominal circumference (AC). Liver function markers (albumin, ALT, and AST) and the serum lipid profile—which included a notable decrease in the amounts of hepatic triglycerides and cholesterol—were both markedly improved. Additionally, oxidative stress and inflammatory indicators showed a considerable decline with VNS. Notably, the liver tissues examined by histopathologists revealed that there is evidence of the protective impact of VNS on the oxidative and inflammatory states linked to HFD-induced NAFLD while maintaining the architectural and functional condition of the liver. Conclusions: Our findings suggest that VNS may represent a promising therapeutic candidate for managing NAFLD induced by obesity. It can be considered to be an effective adjuvant physiological intervention for the obese population with NAFLD to spare the liver against obesity-induced deleterious injury.
Prevalence of RAF1 Aberrations in Metastatic Cancer Patients: Real-World Data
Authors: Lim Sung Hee , Jung Jaeyun , Hong Jung Young , Kim Seung Tae , Park Se Hoon , Park Joon Oh , Kim Kyoung-Mee , Lee Jeeyun
Published: December 2023

Purpose: Therapeutic targeting of RAF1 is a promising cancer treatment, but the relationship between clinical features and RAF1 aberrations in terms of the MAPK signaling pathway is poorly understood in various solid tumors. Methods: Between October 2019 and June 2023 at Samsung Medical Center, 3895 patients with metastatic solid cancers underwent next-generation sequencing (NGS) using TruSight Oncology 500 (TSO500) assays as routine clinical practice. We surveyed the incidence of RAF1 aberrations including mutations (single-nucleotide variants [SNVs]), amplifications (copy number variation), and fusions. Results: Among the 3895 metastatic cancer patients, 77 (2.0%) exhibited RAF1 aberrations. Of these 77 patients, 44 (1.1%) had RAF1 mutations (SNV), 25 (0.6%) had RAF1 amplifications, and 10 (0.3%) had RAF1 fusions. Among the 10 patients with RAF1 fusions, concurrent RAF1 amplifications and RAF1 mutations were detected in one patient each. The most common tumor types were bladder cancer (11.5%), followed by ampulla of Vater (AoV) cancer (5.3%), melanoma (3.0%), gallbladder (GB) cancer (2.6%), and gastric (2.3%) cancer. Microsatellite instability high (MSI-H) tumors were observed in five of 76 patients (6.6%) with RAF1 aberrations, while MSI-H tumors were found in only 2.1% of patients with wild-type RAF1 cancers (p < 0.0001). Conclusion: We demonstrated that approximately 2.0% of patients with metastatic solid cancers have RAF1 aberrations according to NGS of tumor specimens.
Synthesis, Hydrolytic Stability and In Vivo Biological Study of Bioconjugates of the Tetrapeptides FELL Containing Pyrrole Moiety
Authors: Borisova Boryana , Vladimirova Stanislava , Nocheva Hristina , Laronze-Cochard Marie , Gérard Stéphane , Petrin Stoyko , Danalev Dancho
Published: December 2023

Background: Bioconjugates are promising alternatives for the multiple targeting of any disease. Pyrrole heterocycle is well known with many activities and is a building block of a lot of medical drugs. On the other hand, peptides are short molecules with many advantages such as small size, ability to penetrate the cell membrane and bond-specific receptors, vectorizing potential, etc. Thus, hybrid molecules between peptide and pyrrole moiety could be a promising alternative as an anti-pain tool. Methods: New bioconjugates with a general formula Pyrrole (α-/β-acid)-FELL-OH (NH2) were synthesized using Fmoc/OtBu peptide synthesis on solid support. HPLC was used to monitor the purity of newly synthesized bioconjugates. Their structures were proven by electrospray ionization mass spectrometry. The Paw Pressure test (Randall–Selitto test) was used to examinate the analgesic activity. Hydrolytic stability of targeted structures was monitored in three model systems with pH 2.0, 7.4 and 9.0, including specific enzymes by means of the HPLC-UV method. Results: The obtained results reveal that all newly synthesized bioconjugates have analgesic activity according to the used test but free pyrrole acids have the best analgesic activity. Conclusions: Although free pyrrole acids showed the best analgesic activity, they are the most unstable for hydrolysis. Combination with peptide structure leads to the hydrolytic stabilization of the bioconjugates, albeit with slightly reduced activity.
Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP)
Authors: Canfora Federica , Ottaviani Giulia , Calabria Elena , Pecoraro Giuseppe , Leuci Stefania , Coppola Noemi , Sansone Mattia , Rupel Katia , Biasotto Matteo , Di Lenarda Roberto , Mignogna Michele , Adamo Daniela
Published: December 2023

In exploring chronic orofacial pain (COFP), this review highlights its global impact on life quality and critiques current diagnostic systems, including the ICD-11, ICOP, and ICHD-3, for their limitations in addressing COFP’s complexity. Firstly, this study outlines the global burden of chronic pain and the importance of distinguishing between different pain types for effective treatment. It then delves into the specific challenges of diagnosing COFP, emphasizing the need for a more nuanced approach that incorporates the biopsychosocial model. This review critically examines existing classification systems, highlighting their limitations in fully capturing COFP’s multifaceted nature. It advocates for the integration of these systems with the DSM-5’s Somatic Symptom Disorder code, proposing a unified, multidisciplinary diagnostic approach. This recommendation aims to improve chronic pain coding standardization and acknowledge the complex interplay of biological, psychological, and social factors in COFP. In conclusion, here, we highlight the need for a comprehensive, universally applicable classification system for COFP. Such a system would enable accurate diagnosis, streamline treatment strategies, and enhance communication among healthcare professionals. This advancement holds potential for significant contributions to research and patient care in this challenging field, offering a broader perspective for scientists across disciplines.
Reduced Graphene Oxide/Organic Dye Composites for Bioelectroconversion of Saccharides: Application for Detection of Saccharides and α-Amylase Assessments
Authors: Butkevicius Marius , Gaidukevic Justina , Gureviciene Vidute , Razumiene Julija
Published: December 2023

In this study, PQQ-dependent glucose dehydrogenase (PQQ-GDH) was immobilized onto reduced graphene oxide (rGO) modified with organic dyes from three different classes (acridine, arylmethane, and diazo); namely, neutral red (NR), malachite green (MG), and congo red (CR) formed three types of biosensors. All three rGO/organic dye composites were characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy. The impact of three rGO/organic dye modifications employed in bioelectrocatalytic systems on changes in enzyme activity and substrate selectivity was investigated. The highest sensitivity of 39 µA/cm2 was obtained for 1 mM of glucose when a rGO_MG/PQQ-GDH biosensor was used. A significant improvement in the electrochemical response of biosensors was attributed to the higher amount of pyrrolic nitrogen groups on the surface of the rGO/organic dye composites. Modifications of rGO by NR and MG not only improved the surfaces for efficient direct electron transfer (DET) but also influenced the enzyme selectivity through proper binding and orientation of the enzyme. The accuracy of the biosensor’s action was confirmed by the spectrophotometric analysis. Perspectives for using the proposed bioelectrocatalytic systems operating on DET principles for total or single monosaccharide and/or disaccharide determination/bioconversion systems or for diagnoses have been presented through examples of bioconversion of D-glucose, D-xylose, and maltose.
CRISPR/Cas12a-Based Detection Platform for Early and Rapid Diagnosis of Scrub Typhus
Authors: Bhardwaj Pooja , Nanaware Nikita Shrikant , Behera Sthita Pragnya , Kulkarni Smita , Deval Hirawati , Kumar Rajesh , Dwivedi Gaurav Raj , Kant Rajni , Singh Rajeev
Published: December 2023

Orientia tsutsugamushi is responsible for causing scrub typhus (ST) and is the leading cause of acute encephalitis syndrome (AES) in AES patients. A rapid and sensitive method to detect scrub typhus on-site is essential for the timely deployment of control measures. In the current study, we developed a rapid, sensitive, and instrument-free lateral flow assay (LFA) detection method based on CRISPR/Cas12a technology for diagnosing ST (named LoCIST). The method is completed in three steps: first, harnessing the ability of recombinase polymerase for isothermal amplification of the target gene; second, CRISPR/Cas12a-based recognition of the target; and third, end-point detection by LFA. The detection limit of LoCIST was found to be one gene copy of ST genomic DNA per reaction, and the process was complete within an hour. In 81 clinical samples, the assay showed no cross-reactivity with other rickettsial DNA and was 100% consistent with PCR detection of ST. LoCIST demonstrated 97.6% sensitivity and 100% specificity. Overall, the LoCIST offers a novel alternative for the portable, simple, sensitive, and specific detection of ST, and it may help prevent and control AES outbreaks due to ST. In conclusion, LoCIST does not require specialized equipment and poses a potential for future applications as a point-of-care diagnostic.
Assessing the Viability of Waste Plastic Aggregate in Stone-Modified Asphalt Concrete Mix for Bus Rapid Transit Pavement Maintenance
Authors: Ohm Byung-Sik , Kim Kyungnam , Kim Yeong-Min , Le Tri Ho Minh
Published: December 2023

This research takes on a scientific problem originating from the pervasive deterioration observed in the pavements of Bus Rapid Transit (BRT) systems, which presents formidable challenges to their durability and imposes significant financial burdens on BRT organizations. While wear and tear on BRT pavements is a widely recognized concern, there exists a pronounced deficiency in sustainable solutions to address this issue comprehensively. This study endeavored to bridge this scientific gap by exploring the option of incorporating waste plastic aggregate (WPA) and recycled asphalt pavement (RAP) into the pavement material. The series of comprehensive investigations commenced with an assessment of modified binders. We identified a 25% extracted RAP binder as the most suitable candidate. Our research next determined that a 4% WPA content offers optimal results when used as an aggregate replacement in a stone-modified asphalt concrete mix, which is further refined with a 13 mm nominal maximum aggregate size (NMAS) gradation, resulting in superior performance. Under double-load conditions of the Hamburg Wheel Tracking test, rutting in the 10 mm NMAS mixture rapidly increased to 9 mm after 12,400 HWT cycles, while the 13 mm NMAS mixture showed a more gradual ascent to the same critical rutting level after 20,000 HWT cycles (a 61% increase). Real-world application at a designated BRT station area in Seoul reinforced the findings, revealing that the use of 13 mm NMAS with 4% WPA and RAP significantly improved performance, reducing rutting to 75 µm and enhancing pavement resilience. This configuration increased Road Bearing Capacity (RBC) to 5400 MPa at the center zone, showcasing superior load-bearing capability. Conversely, the 10 mm NMAS mixture without RAP and WPA experienced severe rutting (220 µm) and a 76% reduction in RBC to 1300 MPa, indicating diminished pavement durability. In general, this research highlights the need for innovative solutions to address BRT pavement maintenance challenges and offers a novel, environmentally friendly, and high-performance alternative to traditional methods.
Seismic Response Comparisons of Prefabricated and Cast In Situ Subway Station Structures in Liquefiable Site
Authors: An Junhai , Liu Qiaofeng , Zhang Yanhua , Zhang Xuehui
Published: December 2023

Based on the engineering practice of the first prefabricated subway station (Shuangfeng Station) in Changchun, China, the applicability of prefabricated subway station structures (PSSSs) in liquefiable sites in seismically defended areas is investigated. In this paper, the finite difference software FLAC3D 5.0 is used to carry out the seismic response analysis of the PSSS in liquefiable ground, and the calculation results of the PSSS are compared with those of the same type of cast-in-place subway station condition. The results show that the trend of foundation excess pore pressure ratio (EPPR) in the PSSS condition is similar to that of the cast-in-place condition. For different ground vibration inputs, there is not much difference between the PSSS and the cast-in-place structure on the pore pressure (PP) of the surrounding liquefiable soil. The acceleration response of the PSSS is slightly smaller than that of the cast-in-place structure, and it has a better ability to adapt to ground deformation. The deformation of the upper part of the PSSS is slightly larger than that of the lower part, which is an important part of its deformation control, and the middle part is the key part of its strength control due to the presence of the center plate, which results in a significant increase in stiffness and stress. The flexible connection of the PSSS is easier to adapt to a larger vertical deformation than rigid connection, and its ability to resist overturning is better. Under the premise of ensuring static waterproofing, the PSSS can be constructed in liquefiable sites in earthquake-proof areas.
Numerical Simulation of a Masonry Arch Bridge with Initial Defects Based on Cohesive Elements
Authors: Zou Jinsu , Wang Baisheng , Ye Lingpeng
Published: December 2023

Most of the existing masonry bridges have been in service for a significant duration, and as a result of construction limitations, these structures often exhibit intricate geometric defects. Furthermore, under prolonged loading conditions, the rheological behavior of rock can induce deformation in masonry bridges, leading to a continuously evolving stress state. Employing an idealized model for safety assessment frequently results in an overestimation of their load-bearing capacity. To accurately evaluate the load-bearing performance and remaining service life of masonry bridges, as well as to prevent safety incidents, this study employs a parametric approach to establish a two-phase numerical model of masonry bridges. In this model, cohesive elements are introduced to simulate the bonding relationship, while the distribution pattern of geometric initial defects is determined based on the theory of conditional random fields. Additionally, the rheological behavior of rock is incorporated through a custom-written Abaqus user subroutine. Building upon this foundation, the probability distribution of the load-bearing capacity of masonry bridges is reconstructed using the maximum entropy method with fractional moment constraints. The resulting outcomes are compared and validated against those obtained using the decomposition conditional correlation matrix. Finally, the effectiveness and applicability of the proposed method are demonstrated through numerical simulations and field measurements conducted on an actual bridge. The findings reveal that the method introduced in this paper adequately accounts for the stochastic nature of geometric initial defects, objectively reflects the operational performance of masonry bridges, and effectively simulates the complete failure process of such structures. Consequently, this method provides a solid basis for the safety assessment of masonry bridges.
Prediction of an Efficient Energy-Consumption Model for Existing Residential Buildings in Lebanon Using an Artificial Neural Network as a Digital Twin in the Era of Climate Change
Authors: El-Gohary Mohamed , El-Abed Riad , Omar Osama
Published: December 2023

Environmental factors, such as climate change, have serious consequences for existing buildings, including increased resource consumption and footprint, adverse health effects, and reduced comfort for the occupants. To promote sustainability and address climate change, architecture must embrace digitalization. Buildings can be built digitally, analyzed in real time, optimized for energy consumption, and utilized to reduce carbon emissions and achieve zero energy consumption using digital twin technology. Currently, Lebanon’s residents are turning to solar power to generate renewable energy as a result of a lack of energy supplied by the government. In this study, a digital twin model was designed using an artificial neural network (ANN) to investigate the energy consumption of residential buildings. The main idea was to assist architects and engineers in forecasting energy consumption for different design materials by selecting the most effective alternate design for materials with building envelope characteristics, such as exterior walls, roof insulation, and windows, to minimize the consumption of energy in a residential building, hence resulting in a green building. The data simulations used in the digital twin model were carried out using Quick Energy Simulation Tool (eQuest) software; 1540 simulation results were used for different thicknesses of insulation material, values of conductivity, and window types. The digital twins were designed using an artificial neural network model. The results of the investigation and the accompanying eQuest output results were found to be precise and very similar.
One-Year Follow-Up after Multimodal Prehabilitation Interventions in Radical Cystectomy
Authors: Thoft Jensen Bente , Bjerggaard Jensen Jørgen
Published: December 2023

Multimodal prehabilitation is the process of enhancing physiological, nutritional, and psychological resilience to increase patients’ functional capacity before major cancer surgery and aims to empower the patient to withstand the pending stress of major surgery and ultimately to improve long-term outcomes. The effect of physical prehabilitation to counteract the physical decline in surgical cancer patients has been documented; however, long-term results have not yet been published. This follow-up study aims to evaluate 1-year results on the efficacy of physical prehabilitation after bladder cancer surgery. The efficacy of prehabilitation was measured over the course of 1 year in 107 patients randomized to (1) pre- and rehabilitation or (2) standard care divided by n = 50 in the intervention (I) and n = 57 in the standard group (S). Physical function was measured by muscle leg power, and nutritional status was expressed with handgrip strength. Prehabilitation in major bladder cancer surgery can significantly improve physical function with 19.8 Watt/kg (p = 0.04), lean body mass (p = 0.047) and body cell mass (p = 0.03), and regained nutritional status one year after surgery. The results demonstrate that the restoration of physical function is vital to a full recovery.
T12-L3 Nerve Transfer-Induced Locomotor Recovery in Rats with Thoracolumbar Contusion: Essential Roles of Sensory Input Rerouting and Central Neuroplasticity
Authors: Yu Dou , Zeng Xiang , Aljuboori Zaid S. , Dennison Rachel , Wu Liquan , Anderson Jamie A. , Teng Yang D.
Published: December 2023

Locomotor recovery after spinal cord injury (SCI) remains an unmet challenge. Nerve transfer (NT), the connection of a functional/expendable peripheral nerve to a paralyzed nerve root, has long been clinically applied, aiming to restore motor control. However, outcomes have been inconsistent, suggesting that NT-induced neurological reinstatement may require activation of mechanisms beyond motor axon reinnervation (our hypothesis). We previously reported that to enhance rat locomotion following T13-L1 hemisection, T12-L3 NT must be performed within timeframes optimal for sensory nerve regrowth. Here, T12-L3 NT was performed for adult female rats with subacute (7–9 days) or chronic (8 weeks) mild (SCImi: 10 g × 12.5 mm) or moderate (SCImo: 10 g × 25 mm) T13-L1 thoracolumbar contusion. For chronic injuries, T11-12 implantation of adult hMSCs (1-week before NT), post-NT intramuscular delivery of FGF2, and environmentally enriched/enlarged (EEE) housing were provided. NT, not control procedures, qualitatively improved locomotion in both SCImi groups and animals with subacute SCImo. However, delayed NT did not produce neurological scale upgrading conversion for SCImo rats. Ablation of the T12 ventral/motor or dorsal/sensory root determined that the T12-L3 sensory input played a key role in hindlimb reanimation. Pharmacological, electrophysiological, and trans-synaptic tracing assays revealed that NT strengthened integrity of the propriospinal network, serotonergic neuromodulation, and the neuromuscular junction. Besides key outcomes of thoracolumbar contusion modeling, the data provides the first evidence that mixed NT-induced locomotor efficacy may rely pivotally on sensory rerouting and pro-repair neuroplasticity to reactivate neurocircuits/central pattern generators. The finding describes a novel neurobiology mechanism underlying NT, which can be targeted for development of innovative neurotization therapies.
A Peripheral Blood Signature of Increased Th1 and Myeloid Cells Combined with Serum Inflammatory Mediators Is Associated with Response to Abatacept in Rheumatoid Arthritis Patients
Authors: Goutakoli Panagiota , Papadaki Garyfalia , Repa Argyro , Avgoustidis Nestor , Kalogiannaki Eleni , Flouri Irini , Bertsias Antonios , Zoidakis Jerome , Samiotaki Martina , Bertsias George , Semitekolou Maria , Verginis Panayotis , Sidiropoulos Prodromos
Published: December 2023

Abatacept (CTLA4-Ig)—a monoclonal antibody which restricts T cell activation—is an effective treatment for rheumatoid arthritis (RA). Nevertheless, only 50% of RA patients attain clinical responses, while predictors of response are rather limited. Herein, we aimed to investigate for early biomarkers of response to abatacept, based on a detailed immunological profiling of peripheral blood (PB) cells and serum proteins. We applied flow cytometry and proteomics analysis on PB immune cells and serum respectively, of RA patients starting abatacept as the first biologic agent. After 6 months of treatment, 34.5% of patients attained response. At baseline, Th1 and FoxP3+ T cell populations were positively correlated with tender joint counts (p-value = 0.047 and p-value = 0.022, respectively). Upon treatment, CTLA4-Ig effectively reduced the percentages of Th1 and Th17 only in responders (p-value = 0.0277 and p-value = 0.0042, respectively). Notably, baseline levels of Th1 and myeloid cell populations were significantly increased in PB of responders compared to non-responders (p-value = 0.009 and p-value = 0.03, respectively). Proteomics analysis revealed that several inflammatory mediators were present in serum of responders before therapy initiation and strikingly 10 amongst 303 serum proteins were associated with clinical responses. Finally, a composite index based on selected baseline cellular and proteomics’ analysis could predict response to abatacept with a high sensitivity (90%) and specificity (88.24%).
A Nationwide Survey on Patient Empowerment in Pediatric Inflammatory Bowel Disease in Germany
Authors: Kaul Kalina , Schumann Stefan , Sander Cornelia , Däbritz Jan , de Laffolie Jan
Published: December 2023

Background: The incidence/prevalence of pediatric inflammatory bowel disease (IBD) is increasing. IBD places a significant burden on young patients during important developmental stages and affects their families. Children and adolescents with IBD require increased support from health care services. However, little is known about the additional support needed and how to provide it. Therefore, a large survey was conducted with a focus on patient empowerment. Methods: For the anonymous survey, called CEDNA, a patient questionnaire for adolescents with IBD and a questionnaire for parents of children and adolescents with IBD were made available throughout Germany (distributed n = 2810). Questions covered various aspects of coping with the disease, utilization of care, use and need of information and communication services, and how information should be provided. Results: From October 2021 to April 2022, 1158 (n = 708 parents (61.1%), n = 450 patients (38.9%)) questionnaires were completed. The results show a deficit in pediatric IBD care and revealed a large gap in knowledge about core IBD topics (e.g., 74.8% of patients feel poorly informed about transition, 62.4% know little about patient organizations and self-help groups, and 54.7% have little information about preventive health measures), indicating a low level of health literacy among affected children and adolescents. Conclusion: Pediatric IBD poses significant challenges for patients, their families, and healthcare teams. By empowering patients and families, and providing targeted information and communication tailored to the age of the child or adolescent and the needs of the parents, care can be improved and better adapted to the needs of patients. Actions would include providing quality information online through scientific societies and patient organizations and facilitating self-management in adolescents.
Patient Presentations in a Community Pain Clinic after COVID-19 Infection or Vaccination: A Case-Series Approach
Authors: Mailis Angela , Kupferstein Naomi , Assimakopoulos Demetry , Mailis Alex C. , Sutton Sean , Lakha Shehnaz Fatima
Published: December 2023

Objectives: Early case report studies and anecdotes from patients, medical colleagues, and social media suggest that patients may present to chronic pain clinics with a number of complaints post COVID-19 infection or vaccination. The aim of this study is to systematically report on a consecutive series of chronic pain patients seen in a community-based pain clinic, who acquired symptoms after COVID-19 infection or vaccination. Methods: This retrospective cross-sectional descriptive study identified all patients seen at the clinic over a 4-month period (January–April 2022) with persistent symptoms after COVID-19 infection, vaccination, or both. Information was collected on sex, gender, age, details of vaccination, new pains, or exacerbation of old pain plus the development of novel symptoms. Results: The study identified 21 community dwellers (17 females and 4 males; F/M 4.25/1; age range 22–79 years; mean age 46.3 years), with symptoms attributed to COVID-19 infection or vaccination. Several patients suffered exacerbation of previous pains or developed novel pains, as well as high levels of anxiety and mood disorders. A review of the existing literature provides support for the spectrum of symptoms displayed by the study group. Conclusions: Information collected in this study will add to the body of COVID-19-related literature and assist particularly community practitioners in recognizing and managing these conditions.
Durvalumab-Associated Pneumonitis in Patients with Locally Advanced Non-Small Cell Lung Cancer: A Real-World Population Study
Authors: Lim Chloe Ahryung , Ghosh Sunita , Morrison Hali , Meyers Daniel , Stukalin Igor , Kerba Marc , Hao Desiree , Pabani Aliyah
Published: December 2023

The PACIFIC trial led to a new standard of care for patients with locally advanced lung cancer, but real-world practice has demonstrated that immune checkpoint inhibitor (ICI) pneumonitis can lead to significant clinical complications. This study aimed to examine the clinical predictors, outcomes, and healthcare utilization data in patients who received consolidation durvalumab. Using the Alberta Immunotherapy Database, NSCLC patients who received durvalumab in Alberta, Canada, from January 2018 to December 2021 were retrospectively evaluated. We examined incidence and predictive values of severe pneumonitis, with overall survival (OS) and time-to-treatment failure (TTF) using exploratory multivariate analyses. Of 189 patients, 91% were ECOG 0–1 and 85% had a partial response from chemoradiation prior to durvalumab. Median TTF and OS were not reached; 1-year OS was 82%. An amount of 26% developed any grade of pneumonitis; 9% had ≥grade 3 pneumonitis. Male gender and a pre-existing autoimmune condition were associated with severe pneumonitis. V20 was associated with any grade of pneumonitis. Pneumonitis development was found to be an independent risk factor for worse OS (p = 0.038) and TTF (p = 0.007). Our results suggest clinical and dosimetric predictive factors of durvalumab-associated pneumonitis. These results affirm the importance of careful patient selection for safe completion of consolidation durvalumab in real-world LA-NSCLC population.
Automated Machine Learning to Develop Predictive Models of Metabolic Syndrome in Patients with Periodontal Disease
Authors: Boitor Ovidiu , Stoica Florin , Mihăilă Romeo , Stoica Laura Florentina , Stef Laura
Published: December 2023

Metabolic syndrome is experiencing a concerning and escalating rise in prevalence today. The link between metabolic syndrome and periodontal disease is a highly relevant area of research. Some studies have suggested a bidirectional relationship between metabolic syndrome and periodontal disease, where one condition may exacerbate the other. Furthermore, the existence of periodontal disease among these individuals significantly impacts overall health management. This research focuses on the relationship between periodontal disease and metabolic syndrome, while also incorporating data on general health status and overall well-being. We aimed to develop advanced machine learning models that efficiently identify key predictors of metabolic syndrome, a significant emphasis being placed on thoroughly explaining the predictions generated by the models. We studied a group of 296 patients, hospitalized in SCJU Sibiu, aged between 45–79 years, of which 57% had metabolic syndrome. The patients underwent dental consultations and subsequently responded to a dedicated questionnaire, along with a standard EuroQol 5-Dimensions 5-Levels (EQ-5D-5L) questionnaire. The following data were recorded: DMFT (Decayed, Missing due to caries, and Filled Teeth), CPI (Community Periodontal Index), periodontal pockets depth, loss of epithelial insertion, bleeding after probing, frequency of tooth brushing, regular dental control, cardiovascular risk, carotid atherosclerosis, and EQ-5D-5L score. We used Automated Machine Learning (AutoML) frameworks to build predictive models in order to determine which of these risk factors exhibits the most robust association with metabolic syndrome. To gain confidence in the results provided by the machine learning models provided by the AutoML pipelines, we used SHapley Additive exPlanations (SHAP) values for the interpretability of these models, from a global and local perspective. The obtained results confirm that the severity of periodontal disease, high cardiovascular risk, and low EQ-5D-5L score have the greatest impact in the occurrence of metabolic syndrome.
Mortality Trends in Alzheimer’s Disease in Mississippi, 2011–2021
Authors: Jones Elizabeth A. K. , Jenkins Brenda , Addison Clifton
Published: December 2023

Alzheimer’s disease is the sixth most common cause of death in the United States (U.S.), with one in three adults 65 years of age and older dying of the disease each year. Deaths from Alzheimer’s have more than doubled between 2000 and 2019, killing more adults than both breast cancer and prostate cancer. In 2021, Alzheimer’s disease resulted in 36 deaths per 100,000 in the U.S. In Mississippi, deaths from Alzheimer’s have almost doubled between 2011 and 2021, resulting in 52.9 deaths per 100,000. Women have a higher mortality rate from Alzheimer’s than men. Alzheimer’s is a progressive disease that develops through seven stages. There are effective strategies to prevent the onset of Alzheimer’s. Methods: This paper reviews the risk factors, mortality trends, etiology, and prognosis of Alzheimer’s in Mississippi with a focus on prevention. Results: The southern diet with foods high in sugar and sodium, along with sedentary and poor lifestyle choices, increases mortality risk from Alzheimer’s disease for women in Mississippi, specifically due to women over 65 having higher rates of obesity and hypertension. Conclusion: Understanding the epidemiology and risk factors of Alzheimer’s in Mississippi will help inform communities, policies, and programs to prevent disease occurrence.