bluuebunny/crossref_metadata_2025 huggingface dataset:
A Standardized Approach for Skin Detection: Analysis of the Literature and Case-Studies
Authors: Nanni Loris , Loreggia Andrea , Lumini Alessandra , Dorizza Alberto
Published: November 2022

Skin detection, the process of distinguishing between skin and non-skin regions in a digital image, is widely used in a variety of applications ranging from hand gesture analysis to body part tracking to facial recognition. Skin detection is a challenging problem that has received a lot of attention from experts and proposals from the research community in the context of intelligent systems, but the lack of common benchmarks and unified testing protocols has hampered fairness among approaches. Comparisons are very difficult. Recently, the success of deep neural networks has had a major impact on the field of image segmentation detection, resulting in various successful models to date. In this work, we survey the most recent research in this field and propose fair comparisons between approaches using several different datasets. The main contributions of this work are: (i) a comprehensive literature review of approaches to skin color detection and a comparison of approaches that may help researchers and practitioners choose the best method for their application; (ii) a comprehensive list of datasets that report ground truth for skin detection; (iii) a framework for evaluating and combining different skin detection approaches. Moreover, we proposed an ensemble of convolutional neural networks and transformers that obtains state of the art performance. All the code is made publicly available at https://github.com/LorisNanni
Redrawing HER Volcano with Interfacial Processes – the Role of Hydrogen Spillover in Boosting H2 Evolution in Alkaline Media
Authors: Gutić Sanjin J. , Metarapi Dino , Jovanović Aleksandar Z. , Gebremariam Goitom K. , Dobrota Ana S. , Nedić Vasiljević Bojana , Pašti Igor A.
Published: November 2022

The requirements for efficient replacement of fossil fuel, combined with the growing energy crisis, put hydrogen production into focus. Efficient and cost-effective electrocatalysts are needed for H2 production, and novel strategies for their discovery must be developed. Here we utilized Kinetic Monte Carlo (KMC) simulations to demonstrate that hydrogen evolution reaction (HER) can be boosted via hydrogen spillover to the support when the catalyst surface is largely covered by adsorbed hydrogen under operating conditions. Based on the insights from KMC, we synthesized a series of reduced graphene oxide-supported catalysts and compared their activities towards HER in alkaline media with that of corresponding pure metals. For Ag, Au, and Zn, the support effect is negative, but for Pt, Pd, Fe, Co, and Ni, the presence of the support enhances HER activity. The HER volcano, constructed using calculated hydrogen binding energies and measured HER activities, shows a positive shift of the strong binding branch. This work demonstrates the possibilities of metal|support interface engineering for producing effective HER catalysts and provides general guidelines for choosing novel catalyst-support combinations for electrocatalytic hydrogen production.
PELATIHAN MENGEMBANGKAN SOAL BERFIKIR TINGKAT TINGGI (HOTS) PARA GURU GEOGRAFI SMA SE PROVINSI LAMPUNG
Authors: Maryani Enok , Yani Ahmad
Published: November 2022

dalam presepsi dan keterampilan guru geografi dalam mengkontruksi instrumen pengukuran hasil belajar berorientasi HOTS. Metode pelaksanaan kegiatan ini terdiri dari tiga tahap yakni tahap penyampaian materi, tahap kegiatan mandiri peserta dan tahap refleksi terhadap hasil kerja mandiri peserta. Hasil pada artikel ini menunjukkan bahwa beberapa presepsi jawaban guru yang dapat disimpulkan bahwa pelaksanaan pengabdian kepada masyarakat ini sangat urgen guna meningkatkan kompetensi guru dalam mengkontruksi instrumen hasil belajar pada mata pelajaran geografi serta soal-soal HOTS yang dibuat oleh peserta menggambarkan bahwa perlunya kegiatan pengabdian kepada masyarakat mengenai pelatihan menulis soal HOTS secara berkelanjutan guna dapat memantapkan kompetensi guru dalam menulis soal HOTS secara konseptual maupun praktiknya. Dalam kegiatan pengabdian ini guru-guru juga diajak untuk membuat soal HOTS yang dijadikan bank soal mata pelajaran geografi berorientasi HOTS yang merupakan luaran dari kegiatan pengabdian kepada masyarakat ini.

 

Kata Kunci: Kompetensi guru, HOTS, Geografi, Instrumen pengukuran hasil belajar
SOSIALISASI: “PENTINGNYA EMPATI DAN RASA BERGOTONG-ROYONG” DI DUSUN SAMBONG DURAN
Authors: Indah Diah
Published: November 2022

Pengabdian masyarakat dapat dilakukan dengan berbagai cara selama tidak menghalangi atau menyimpang dari tujuan sebenarnya. Kegiatan ini merupakan salah satu jalan yang dapat membantu memberikan solusi dari masalah yang ada atau yang sedang terjadi di lingkungan sekitar mengingat bahwa kegiatannya sejalan dengan kondisi, sikap dan perilaku yang mengarah pada modernisasi sehingga membantu menciptakan bangsa yang cerdas dalam mengambil setiap langkah untuk memecahkan permasalahannya dengan baik dan sesuai nilai-nilai sosial budaya yang berlaku. Tujuan dari kegiatan pengabdian kepada masyarakat yang menjadi topik penulisan ini yaitu untuk membantu mempereratkan solidaritas antar warga Dusun Sambong Duran agar mereka memiliki rasa empati satu sama lain dan juga muncul kesadaran bergotong-royong. Metode yang dipakai berupa sosialisasi kepada warga setempat memberikan pengertian dan pemahaman tentang rasa empati dan bergotong-royong, lalu menjelaskan dampaknya serta memberikan contoh implementasi dalam kehidupan bermasyarakat. Hasil yang diperoleh dari kegiatan tersebut adalah terdapat perubahan signifikan pada suasana dan kondisi yang menuju kearah suatu hal bersifat positif dan keadaan lebih harmonis daripada sebelumnya kepada antar warga di lingkungan Dusun Sambong Duran.
Peningkatan Keterampilan dalam Pengolahan Variasi Olahan Ikan dengan Teknik Pengeringan di Desa Pantai Mekar Kecamatan Muara Gembong Kabupaten Bekasi
Authors: Hendrawan Rina Febriana , Yeni Yulianti  , Hanafi Ivan Hanafi
Published: November 2022

Kecamatan Muara Gembong merupakan wilayah pesisir dan perikanan terbesar dibandingkan kecamatan lain di Kabupaten Bekasi. Potensi yang dapat diangkat dari Kecamatan Muara Gembong antara lain tangkapan hasil laut dari nelayan di Pantai Mekar yang dapat dijadikan bisnis kuliner sehat yang turut mendukung desa wisata Tujuan pengabdian pada masyarakat (PKM) ini adalah (1) memberikan wawasan kepada warga di Kecamatan Muara Gembong Desa Pantai Mekar dalam pengolahan variasi olahan ikan dengan teknik pengeringan; (2) melatih warga di Kecamatan Muara Gembong Desa Pantai Mekar dalam membuat kerupuk ikan  dan (3) ) melatih warga di Kecamatan Muara Gembong Desa Pantai Mekar dalam membuat abon ikan. Metode yang digunakan adalah demosntrasi, diskusi, dan tanya jawab. Setelah kegiatan pelatihan peserta mengisi kuesioner evaluasi untuk menilai penyelenggaran kegiatan pelatihan. Hasil PKM yang dicapai adalah peningkatan dalam aspek (1) wawasan/pengetahuan warga Desa Pantai Mekar dalam pengolahan variasi olahan ikan dengan teknik pengeringan meningkat, menunjukkan nilai gain 0,69  yang diperoleh dari hasil pre test dan post test; (2) keterampilan dalam membuat kerupuk ikan, dan (3) keterampilan dalam membuat abon ikan. Dampak dari pelatihan ini warga memiliki wawasan baru tentang cara membuat olahan ikan dengan teknik pengeringan sederhana sebagai salah satu upaya memaksimalkan pengolahan hasil laut dan peningkatan pendapatan keluarga.
Workshop Persiapan Kerja untuk Calon Lulusan SMKN1 Lemahsugih Majalenegka Jawa Barat
Authors: Kurniawan Mochamad Teguh , Fathinuddin Muhammad
Published: November 2022

Jawa Barat merupakan salah satu provinsi yang sangat potensial di Indonesia. Salah satu potensi yang di miliki Jawa Barat adalah ketersediaan sumber daya manusia (SDM). Dan salah satu indikator keberhasilan suatu daerah adalah tersediannya SDM yang berkualitas Salah satu tempat untuk meningkatkan SDM adalah sekolah formal. Salah satu tingkatan sekolah formal adalah Sekolah Menengah Kejuruan (SMK). SMK merupakan tempat proses belajar mengajar yang menitik beratkan kepada keahlian dari siswa untuk siap bekerja. Yang menjadi tantangan SMK adalah proses melamar kerja setelah lulus, kebanyakan siswa tidak update terhadap dunia kerja padahal mereka disiapkan untuk langsung bekerja. Kebanyakan lulusan SMK masih banyak yang belum siap menghadapi dunia kerja. Terutama mereka bingung memulai dari mana untuk mencari kerja, melamar dan awal kerja. Dalam pengabdian masyarakat ini dipilih mitra dari wilayah pelosok yaitu SMKN 1 Lemahsugih yang berada di Kabupaten Majalengka yang merupakan kecamatan terpencil. Berdiri pada tahun 2006 menyebabkan sekolah ini masih sangat minim pengalaman untuk mengurus lulusan dan mempersiapkannya dalam dunia kerja. Sehingga tidak heran lulusan SMK ini masih banyak yang menganggur. Selain itu, lokasi sekolah yang berada jauh dari ibukota Kabupten Majalengka membuat sekolah ini semakin ketinggalan terhadap informasi terutama lowongan pekerjaan. Luaran dari pengabdian masyarakat ini yaitu jasa. Dimana akan dilakukan berupa workshop untuk mempersiapkan lulusan yang siap menghadapi dunia kerja mulai dari cara mencari kerja, mempersiapkan lamaran dan CV, serta teknik wawancara. Dari survey yang dilakukan sebelum dan sesudah pelatihan terjadi peningkatan pengetahuan dari siswa terhadap dunia kerja, cara membuat lamaran dan cv, dan persiapan wawancara kerja. Dan mereka lebih siap dalam menghadapi dunia kerja
A Newly Hybrid Version of African Vultures Optimization Algorithm and Sine Cosine Algorithm for Mammographic Masses and its Diagnosis
Authors: Kaur Navneet , Kaur Lakhwinder , Cheema Sikander Singh
Published: November 2022

From the last few periods, breast cancer is the foremost reason for cancer-related huge death rates in the midst of females. However, the recent study detection and diagnosis of these types of issues can successfully decrease the death rate. Masses are unique indicators of undetectable breast cancer noticeable in mammograms whose identification and judgment is a more complex or stimulating job due to its restrained natural surroundings. The seriousness of this issue is to motivate the scientists of different areas for their solution. With the great inspiration of this learning, in this work we are tried to present a new hybrid algorithm with the integration powerful features of two different algorithms such as African Vultures Optimization Algorithm (AVOA) and Sine Cosine Optimization Algorithm (SCA) and it is called AVSC method for identify the breast cancer. The features of the sine cosine algorithm helps to improve the exploitation and exploration phases of the basic AVOA method. This enhancement has been designed to improve the premature convergence, avoiding the local optima and fast convergence speed and many more. To verify the performance of the proposed scheme have been verified 29-CEC ’2017 test functions. Moreover, the AVSC method has been successfully applied on the two different mini-MIAS and DDSM databases including 68 and 500 mammograms, etc and attained a highest rate of sensitivity and false positives per image for the respective datasets. Hence, the tabulated results give the strong evidence that the AVSC is able to effectively resolve the highly complex tasks that others whole could be more helpful in biomedical sciences.
Cerliponase alfa in the treatment of patients with classic and atypical late infantile neuronal ceroid lipofuscinosis in Latin America
Authors: Guelbert Norberto , Segura Oscar M Espitia , Amoretti Carolina , Arteaga Angélica Arteaga , Atanacio Nora G , Bazan Natacha S , Carvalho Ellaine D.F , de Andrade María D. F Carvalho , Denzler Inés M , Durand Consuelo , Ribeiro Erlane M , Giugni Juan C , González Gabriel , Moron Dolores González , Guelbert Guillermo , Rodriguez Zulma J Hernández , Embiruçu Emilia K , Kauffman Marcelo A , Mancilla Nury I , Marcon Laureano , Pereira Alessandra Marques , de Souza Carolina F Fischinger Moura , Muñoz Victor A , Florez Ricardo A Naranjo , Pessoa André L , Ruiz Maria V , Villareal Martha M Solano , Spécola Norma , Tavera Lina M , Tello Javiera , Schifferli Mónica Troncoso , Urgrina Sonia , Vaccarezza María M , Vergara Diane , Villanueva María M
Published: November 2022

Introduction: Late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), is a neurodegenerative autosomal recessive disease caused by TPP1 gene variants, with a spectrum of classic and atypical phenotypes. The aim of treatment is to slow functional decline as early as possible, improving quality of life and survival. This study describes the clinical characteristics as well as response to treatment with cerliponase alfa.
Materials and Methods: A retrospective study was conducted in five Latin-American countries, based on clinical records from patients with CLN2. Clinical follow-up and treatment variables are described. A descriptive and bivariate statistical analysis was performed.
Results: A total of 36 patients are reported with a mean age of symptom onset and time to first specialized consultation of 4.7±2.3 and 6±3.1 years, respectively. Seizures were the predominant symptom (80.6%). In a subgroup analysis, most patients with the classic phenotype exhibited regression in language (90%), while the patients with the atypical phenotype had seizures as the predominant symptom (87%). The mean age of symptom onset and time to first specialized consultation was 3.5±2.0 and 4.9±3.2 years, respectively, in patients with the classic phenotype and 6.2±1.8 and 7.5±2.4 in patients with the atypical phenotype. The mean time interval between onset of symptoms and treatment initiation was 3.8 years in patients with classic phenotype and 7.4 in patients with atypical phenotype. All patients were treated with cerliponase alfa, maintaining overall functional stability as compared to pretreatment values.
Discussion and conclusion: This study reports at this time the largest number of patients with CLN2 in treatment with cerliponase alfa in the world. Data show a higher frequency of patients with atypical phenotype and a high allelic proportion of intron variants in our region. There was evidence of long intervals until first specialized consultation, diagnosis, and enzyme replacement therapy. Follow-up after the initiation of cerliponase alfa showed slower-to-no-progression of the disease, associated with adequate clinical outcomes and stable functional scores. These improvements were consistent in both clinical phenotypes.
Skill-biased Technical Change and Intergenerational Education Mobility
Authors: Aziz Imran
Published: November 2022

This paper analyzes the impact of skill-biased technological change (SBTC) on intergenerational education mobility. I set up an SBTC model with an overlapping generations framework, where heterogeneously-skilled households invest in their children's education to make them skilled. Technology incentivizes these investments by creating both pecuniary (higher skill-premium) and non-pecuniary (improved life skills) benefits; it constrains investments among low-income households by increasing inequality. I show there is a critical technology range within which SBTC shocks can increase investments by both high-income and low-income households, improving absolute education mobility. Moreover, the relative increase in transfers can be larger for the low-income group who initially have lower investment levels, which can help their children catch-up. I test the predictions of the model using data from Chetty et al. (2014) which show how college attendance rates of children in U.S. commuting zones (CZs) are linked to the rank of their families in the national income distribution. A technology measure is constructed for each CZ using its share of STEM workers, which I instrument using a Bartik-type IV to deal with endogeneity concerns. From 2SLS estimations, I find that college attendance rates of children from households in the same income rank improve if households are located in higher technology CZs, with the improvement being larger among lower-ranked households. Thus, SBTC is found to improve both absolute and relative intergenerational education mobility.
JEL Codes: J24, J31, J62, I24, O33
Behavioural hormoligosis in oviposition preference of Bemisia tabaci Gennadius on egg plant
Authors: Dumra Neeru , Rolania Krishna , Yadav Surender Singh , Mandhania Shivani
Published: November 2022

The study tests the impact of sublethal dose on oviposition preference in Bemisia tabaci (Gennadius) on treated brinjal plant using the multiple-choice test during 2019 and 2020 season. Diafenthiuron 50% WP (150, 210, and 300 g a.i./ha), fenpropathrin 30% EC (50, 70, and 100 g a.i./ha), thiamethoxam 25% WG (25, 35 and 50 g a.i./ha) and deltamethrin 2.8% EC (7.5, 10.5 and 15 g a.i./ha) were repeatedly sprayed on brinjal plants (var. Hisar Shyamal) growing in pots. The effectiveness of these insecticides was assessed based on the preference of B. tabaci (whitefly) for oviposition on treated plants. Additionally, this study tested variations in the biochemical components of treated brinjal leaves and their relationship to the propensity for oviposition. The results revealed that fenpropathrin 30% EC and deltamethrin 2.8% EC treated plants were more preferred by whitefly for oviposition. Maximum number of eggs were laid on sublethal dose of fenpropathrin30% EC treated plants at 50 g a.i./ha (42.93 eggs/ leaf) and deltamethrin 2.8% EC at 7.5 g a.i./ha (39.57 eggs/leaf) followed by fenpropathrin30% EC at 70 g a.i./ha (39.02 eggs/ leaf) compared to untreated control (26.74 eggs/leaf). An almost similar trend of results was observed in the repeated experiment in 2020. The results obtained from biochemical studies revealed that all the insecticidal treatments caused a reduction in total sugars and amino acids except lower dose of fenpropathrin 30% EC, and deltamethrin 2.8% EC. Also, all the insecticides caused a reduction in total phenol content and brought significant changes in crude protein content. Hence, fenpropathrin 30% EC and deltamethrin 2.8% EC treated brinjal plant is nutritionally superior host for whitefly and led to behavioural hormoligosis in oviposition preference by whitefly. The results of this study would benefit agricultural practitoners and farmers.
Self-rationing and small business success: the moderate role of informal finance
Authors: ERIOLA Jesse Akitola , HOUNKOU Emmanuel Cossi
Published: November 2022

This study investigates the relationship between small business success and formal finance self-rationing by highlighting the moderate effect of informal financing. A structural equation method is realized using questionnaire survey data from a sample of 293 Beninese small business managers. Overall, the study shows that the majority (more than 65%) of small businesses are self-rationed. Almost 40% of respondents have got financing support from their family or friends and about 38% apply for tontine. Additionally, we find that self-rationing negatively and significantly affects small business success. We also find that informal financing moderates the relationship between self-rationing and small business success. Thus, When the managers perceive more guarantees required, high costs, and difficulties in the application process for formal financing, they use informal funding to overcome these difficulties to reach success. Furthermore, our findings suggest that the government should target and organize informal financing, especially tontine. Formal institutions especially banks are to consider interpersonal factors to facilitate the financing conditions for small businesses instead of always focusing their attention only on the classic process to resolve the higher cost of financing problem and reduce the asymmetric information problem.
Value Chain Hygiene Practices and Microbial Contamination of Street and Market Vended Ready-to-Eat grasshopper, Ruspolia differens in Uganda: Implications for food safety and public health
Authors: Rutaro Karlmax , Hawumba Joseph , Nakimuli Jane , Mulindwa Julius , Malinga Geoffrey M. , Baingana Rhona
Published: November 2022

Background
Food safety is a major public health issue, particularly in developing countries. Ready-to-eat street-vended foods contribute to daily dietary life, but with elevated food safety burden. Here, hygiene and food safety practices as well as the microbial contamination in Uganda's edible grasshopper value chain was evaluated.
Methods
This was a cross-sectional mixed methods study with both qualitative and quantitative approaches. A face-to-face administered questionnaire and observational checklists were used to collect data. A total of 29 households (Kampala; 12 and Masaka; 17) participated, and grasshopper samples collected along the value chain. Indicator pathogens were analysed using standard microbiological methods.
Results
Sociodemographic characteristics reveal that two-thirds of households in Kampala and 53% in Masaka were female headed. In Kampala and Masaka, respectively, 50% and 12% of households had earth or sand floors. All households in Kampala were one or two-roomed dwellings with no separate room as a kitchen, and shared a toilet compared to 43%, 65% and 53%, respectively, in Masaka. 83% households in Kampala and 56% in Masaka obtained drinking water from public taps. Handwashing was inadequate and none of the actors was observed to wash their hands after taking a break or handling waste. Only 8.3% respondents had raised racks for drying utensils. For vendors, wearing protective clothing was not common, with only 28.5% in Kampala and 30.8% in Masaka wearing an apron. Containers for vending grasshoppers were largely uncovered and the utensils (spoon or cup) for measuring the grasshoppers were left mainly uncovered during the observation period. Indicator organisms, E. coli and Salmonella typhimurium, were detected. E. coli was the most common contaminant, but with lower levels in Masaka compared to Kampala. Salmonella typhimurium was mainly a burden in Kampala.
Conclusions
Our findings demonstrate that there are enormous contributors to poor hygiene and sanitation along the value chain. The existence of pathogenic bacteria such as E. coli in ready-to-eat foods imply that their consumption pose a health risk. There is an urgent need to create awareness among the actors,through regular trainings on food safety and personal hygiene practices in food handling and inspection to prevent foodborne disease outbreaks.
Optimization of land suitability evaluation, using fuzzy analytic hierarchy process(FAHP) base on parametric evaluation method
Authors: Hoseini Yaser
Published: November 2022

New irrigation field assessment strategies can be used to improve water use performance in agriculture. In this study, the fuzzy Analysis Hierarchical Process (FAHP) for qualitative soil suitability for drip irrigation is used and compared with conventional parametric approaches. An assessment based primarily on a fully parametric approach identified sites with approximately 2941 hectares (57%) of land to be 'Very Suitable (S1)'. and an area of about 247 hectares (5%) of areas, was “Partly appropriate (S2)” and about 798 hectares (15%) were “Approximately appropriate (S3)”. “Permanently inappropriate (N2)” included about 452 hectares (9%) and “Inappropriate in present condition (N1)” suitability matched 737 hectares (14%) in the study zone. Based on the Fuzzy Analytic Hierarchical Process(FAHP), (S1) suitability included an area of about 2873 hectares (56%) and the parts with (S2) suitability, also included an area of about 2100 hectares (41%). Moreover, areas of about 130 hectares (3%) were “Approximately appropriate (S3)”. Some southwest and west parts of the plain were “Inappropriate in present condition (N1)”, that included an area of about 72 hectares (1%). Also, there were no “Permanently inappropriate (N2)” regions in the plane based on the FAHP method. As a result, there was no significant difference between the two methods in terms of "highly suitable lands”. However, in the fields with (S2) fitness, the differences between the methods are very large, with the FAHP method showing higher field fitness than the conventional parametric method. We point out that FAHP assessment is more accurate than traditional parametric methods of assessing soil suitability, considering the gradual changes in soil properties. Considering the slow changes in the soil-influencing parameters and the variable membership functions of these parameters, and the different weightings of the indices influencing the evaluation, the anomalous influence of the factors on the final characterization was reduced by the FAHP method and the evaluation approaches its true value.
Determinants of household rural poverty in Tenta Woreda, South Wollo Zone, Ethiopia
Authors: Bekele Ayisheshim , kassa Mengesha
Published: November 2022

Poverty in Ethiopia is multidimensional caused by a set of factors ranging from those related to past macro-economic policies and socio-political history of the country. This study examines rural poverty and its determinant at household level. Primary data were collected by using structured questionnaires, interview and focus group discussion. Secondary data also used from different published and unpublished materials. The results are based on the data collected from three selected peasant associations about 196 rural household were taken by simple random sampling. The researcher used Foster Greer-Thorbecke, binary logistic regression model, descriptive statistics and Cost Basic Needs- to find out the determinants of rural poverty at household level. The result of the analysis indicates that poverty status is strongly associated with almost all variables. Household head sex, household family size, and land holding size, oxen and other livestock, small ruminant holding size are significantly important determinants of rural poverty in the study area i.e. households headed by females and big size of the family experience more poverty in the study area. On the other hand, variables such as land, oxen, livestock and small ruminant holding size negatively related with poverty so that households with larger number of land, oxen, livestock and small ruminant are better off than those with smaller number. It is recommended that integrated agricultural research and extension program, family planning, reducing gender based labor division, land distribution and promotion of effecting resettlement program would have indispensable role to reduce poverty in the area.
Revision to the chronology of the early transgressive phase of Lake Bonneville
Authors: Oviatt C. G.
Published: November 2022

Newly available 14C and U-Th ages for microbialites at Death Point (on the shore of Great Salt Lake at Lakeside, UT; Jour Quat Sci 2022) call for a major revision of the Lake Bonneville hydrograph. At the beginning of the Lake Bonneville cycle, the lake experienced an abrupt rise about 30,000 cal yr BP, then dropped back down to levels near the modern elevation of Great Salt Lake, then over the ensuing 6 thousands of years the lake experienced a series of fluctuations, up to levels a few 10s of meters higher than average Great Salt Lake levels then down again. The exact timing and amplitudes of those fluctuations are not known at this time, but importantly the lake did not rise to levels near the Stansbury shoreline until after about 24,000 cal yr BP. Although the Stansbury oscillation(s) occurred during the transgressive phase of Lake Bonneville, not during the regressive phase, as was traditionally thought, the oscillation(s) were younger than 24,000 cal yr BP. This interpretation conflicts with previously published chronologies.
PRKCB is a novel and potential biomarker in colon cancer and shapes an inflamed tumor immune microenvironment
Authors: Wen Su , Zeng Hao , An Kangli , Wu Shuang , Huang Xueqing , Shao Zhuo , Bai Jing , Yin Tiejun
Published: November 2022

Background
Only a small subset of colon cancer patients with mismatch repair deficiency may also benefit from Immune checkpoint inhibitors (ICIs). New biomarkers correlated with ICIs responsiveness need to be explored.
Methods
The study data were obtained from TCGA, GEO, cBioPortal, UALCAN, UCSC Xena browser, and CPTAC databases. Protein kinase C beta (PRKCB) was screened via weighted gene co-expression network analysis (WGCNA), survival analysis and differential expression analysis. The biological and immune landscape of PRKCB was explored by performing bioinformatics and immunohistochemical analyses. These findings were used to predict responsiveness to immunotherapy.
Results
Yellow module in WGCNA, as a hub module, was strongly positively correlated with infiltrated CD8 + T cell and Immune Score. PRKCB was an essential member of the yellow module, downregulated in colon cancer tissue, and associated with poor prognosis. GO, KEGG, REACTOME enrichment analysis showed PRKCB was associated with Cytokine-cytokine receptor interaction, Chemokine signaling pathway, T cell receptor signaling pathway, NF-κB signal pathway, Natural killer cell mediated cytotoxicity, and PD-L1 signaling. Meanwhile, the PRKCB expression was highly positively correlated with the infiltration of the CD4 + T cells, CD8 + T cells, and NK cells. Moreover, the immunohistochemistry analysis of tissue microarray demonstrated that PRKCB expression was positively correlated with infiltrated CD8 + T cell and PD-L1 expression. As expected, the TIDE and SubMap algorithm verified that ICIs could be effective in PRKCB-high patients.
Conclusion
PRKCB-high was associated with good prognoses in colon cancer patients. PRKCB-high was an indicator of inflamed TIME, which correlated with high responsiveness to immunotherapy in colon cancer patients.
Pinocembrin inhibits migration and invasion of non-small cell lung cancer cells by inhibiting STAT3 signaling
Authors: Zhang Jing , Xue Zhiqiang , Wang Bin , Wen Jiaxin , Wang Yunxi
Published: November 2022

Background
STAT3 activation plays a pivotal role in promoting ETM-mediated tumor progression and metastasis and has been considered as a target for the treatment of cancer. Pinocembrin, a natural dihydroxyflavanone found in propolis and honey, has antioxidant and vasodilating properties. In this study, we aim to investigate the role of pinocembrin in inhibiting cells migration and invasion via regulating STAT3 signaling in non-small cell lung cancer cells.
Methods
A549 cells migration and invasion were determined by hematoxylin staining. Relative expression of ETM-related proteins and invasive proteins in A549 cells were determined by western blot. STAT3 activity was evaluated by luciferase assay. Overexpression of STAT3 were used to assess the role of pinocembrin in regulating STAT3.
Results
The number of migrating and invasive cells were significantly reduced by the treatment of pinocembrin. The protein level of E-cadherin was upregulated, and the protein levels of N-cadherin and vimentin were downregulated by pinocembrin. The phosphorylation and activation of STAT3 were blocked by pinocembrin. Overexpression of STAT3 reversed the inhibitory effects of pinocembrin on cells migration and invasion.
Conclusion
Our results suggested that pinocembrin can inhibit STAT3 activation mediated ETM transformation, thereby attenuating migration and invasion in non-small lung cancer cells. Given the significance of STAT3 activation, our findings showed that pinocembrin, by inhibiting STAT3 activation mechanistically, could potentially serve as an effective therapeutic approach for the treatment and management of lung cancer in clinical.
Bounded Rational Bidding Decision for Land Auction in the Context of Real Estate Economic Transformation and Upgrading
Authors: Liao Rujin , Zhang Jing , Tan Ruwen , Wu Yilin , Yu Minjiu
Published: November 2022

Unlike the rapid growth period of China's real estate market, full rational bidding decisions can no longer provide a sufficient theoretical basis for developers’ bidding decisions in land auctions under the transforming and upgrading market. Based on the first-price sealed-bid auction, this paper firstly establishes the standard model where bidders are fully rational, then referring to the research results of behavioral finance, creatively proposes two models under the assumption of bounded rationality of bidders to explain the current situation of the land auction, namely the reference utility model and the Subjective decision probability model. And we analyze the differences between the fully rational assumption model and the bounded rationality assumption models by comparing them. The main conclusions are 1) The assumption of bounded rationality is more consistent with the state of the current market; 2) Land grantors should consider developers' profit margins according to the market background; 3) Under the influence of subjective decisions, the competition of cost advantage developers will intensify while the cost disadvantage developers will be indifferent.
Electrospinning of NH 2 -MIL-88B(Fe)/TiO 2 /PAN (NMTP) nanofiber membranes：photocatalytic degradation tetracycline and efficient oil-water separation applications
Authors: Guo Ruibin , Wang Bingjie , Li Li , Niu Hewen , Guo Wei , Pei Hebing , Chen Qianglong , Liu Nijuan , Mo Zunli
Published: November 2022

Excessive discharge of TC poses a threat to the environment and human health, while finding a cost-effective treatment method to remove TC from water still remains a challenge. In this study, NH2-MIL-88B(Fe)/TiO2/PAN (NMTP) electrospinning nanofibrous membranes (ENMs) were prepared, and the NMTP ENMs were characterized by SEM, XRD, UV-vis and other characterization methods. The results show that the introduction of NH2-MIL-88B(Fe) expands the photoresponse range of ENMs and improves the hydrophilicity of the membranes, NMTP ENMs exhibit excellent photocatalytic performance during the photocatalytic process, and the best sample has excellent photocatalytic performance for TC. The degradation efficiency can reach 93.0%. After 4 times of photocatalytic regeneration, the removal rate still remains about 80%, and its recovery performance is high. The best degradation efficiency of CTC and OTC can reach 94.9% and 86.5%, respectively. In the oil-water separation experiment, the NMTP ENMs exhibited excellent separation performance and high throughput for oil-in-water emulsions, with separation efficiencies of 98.15%, 97.43% and 84.87% for toluene-in-water, n-heptane-in-water and n-hexane-in-water emulsions, respectively. Based on the above results, this study provides a new strategy for developing efficient and stable technologies for simultaneous catalysis and separation of oil-in-water emulsions.
Primary gastric Burkitt’s Lymphoma mimicking gastric cancer: a case report
Authors: Geng Siyi , Chu Yi , Zhou Peng , Zhu Hongyi
Published: November 2022

Burkitt’s Lymphoma is a highly malignant B-cell non-Hodgkin’s lymphoma that is extremely sensitive to intensified chemotherapy and its occurrence is closely associated with Epstein-Barr virus. Extranodal lymphoma often involves the gastrointestinal tract, but primary gastrointestinal lymphoma is rare, and primary gastric Burkitt’s Lymphoma is even rarer. We report a case of upper abdominal distension, eventually diagnosed as primary Burkitt’s Lymphoma of the stomach, including clinical manifestations, diagnosis and treatment. The patient showed favorable treatment response to intensified combination chemotherapy. We evaluate treatment response through endoscopy and radiological tests. This report suggested that primary gastric Burkitt’s Lymphoma is a rare yet treatable disease. The etiology and prognosis of Burkitt’s Lymphoma need to be explored in the future.
Synchronous double primary lung cancer with cystic airspaces: a case report and literature review
Authors: Wang An , Du Yu , Ma Qinyun , Chen Xiaofeng
Published: November 2022

Background: Synchronous double primary lung cancer (SDPLC) is the most common type in multiple primary lung cancer (MPLC), which is a rare type of lung cancer. Lung cancer combined with cystic airspaces is relatively rare in imaging manifestation.
Case presentation: Here, we reported a case with SDPLC which consisted of squamous cell carcinoma and mucinous adenocarcinoma with cystic airspaces. A new solid nodule developed form cystic airspaces in the left lower lung in three months after the right inferior lung cancer radical surgery. Left pleural effusion appeared in two months after the second left inferior lung cancer radical surgery. The patient died of severe immune-related pneumonitis induced by Camrelizumab in the fourth cycle of postoperative treatment.
Conclusion: Synchronous double primary lung cancer with cystic airspaces have never been reported before, and no SMPLC cases with rapidly and poorly prognosis were reported. Therefore, we must pay more attention to the rapid progress of mucinous adenocarcinoma with cystic airspaces.
Retrospective Drug use Evaluation of Ceftriaxone In Resource Limited Setting In Case Of Bedele General Hospital, Ethiopia
Authors: Jifar Wakuma Wakene , Adugna Debisa , Gadisa Bontu , Debele Gebiso Roba , Admasu Tesfaye Tsegaye
Published: November 2022

Background: Anti-microbial resistance (AMR) due to the over use of the reserved antibiotics like ceftriaxone is one of the threatening global issues of public health and many patients suffer due to harms arising from AMR because the infections caused by viruses, bacteria, fungi, protozoa and helminthes are no longer susceptible to the commonly available antibiotics.
Objective: To evaluate the utilization pattern of ceftriaxone at Medical Ward in Bedele General Hospital, Bedele, South West Oromia, Ethiopia.
Methodology: Patients' medical record cards (PMRCs) from the medical ward at Bedele General Hospital who took ceftriaxone between July 1 and December 30 of 2021 were the subject of a hospital-based retrospective cross-sectional study design and the selection of the medical record cards was done using a systemic random sample technique. Utilizing current Ethiopia's Standard Treatment Guideline for General Hospital and Drug Use Evaluation Criteria, the appropriateness of the ceftriaxone usage was assessed.
Results: A total of 212 patients’ medical records were reviewed and the most frequent age group was adults in the range of 18-65 (80.5%) and the use of ceftriaxone was inappropriate in 185 cases (47.1%). Ceftriaxone was mainly used for the treatment of pneumonia condition (46.2%), regarding ceftriaxone dosage in our study, the majority of patients received 2 g/day (85.4%) and the mean duration of ceftriaxone therapy in our study was 11.47 days, with a range of 2-7 days (49.7%). Maintenance fluids were the most commonly co-administered medications with a frequency of 32.9%. Conclusions: Prescribers should follow the national standard treatment guideline in order to increase rational use of ceftriaxone and stop the emergence of resistance. The hospital may choose to implement antimicrobial control systems and short-term training for health care professional in order to adhere the treatment guideline is our recommendation.
Predominant contribution of an endogenous cellulase to the cellulolysis in the digestive system of grub of banana pseudostem weevil, Odoiporus longicollis (Coleoptera: Curculionidae)
Authors: Bhuvaragavan Sreeramulu , Reshma Thenozhiyil , Hilda Karuppiah , Meenakumari Mani , Sru Kannan , Nivetha Ramanathan , Janarthanan Sundaram
Published: November 2022

Insects have evolved with effective strategies to utilize cellulose as energy source by possessing novel cellulolytic enzymes which can be used as an optimal resource in the bioenergy sector. The study was aimed for evaluating the cellulolytic enzyme in the grub gut of banana pseudostem weevil, Odoiporus longicollis Olivier (Coleoptera: Curculionidae). Primarily, cellulase activity was localized in the gut system, in which the midgut showed the highest activity. The optimum temperature and thermo-tolerance of cellulase activity were found to be 60°C, and was stable at a pH between 5 and 6. Various concentrations of divalent cations (CaCl2, MgCl2, and CuCl2) have differential enhancing and inhibitory effects on cellulase activity. The cellulase was purified using anion exchange chromatography. The specific activity of purified cellulase was 1190.46 U mg− 1. The molecular weight of the cellulase was determined to be 47 kDa. The physicochemical parameters of purified enzyme were similar to that of enzyme activity of crude extract. Mass spectrometry results identified this cellulase was of GHF5 family. The gut microbial cellulase activity as exogenous source showed no competence comparatively.
Fatty Acid Content and Physicalchemical Properties of Cagaite Seed Oil (Eugenia dysenterica DC) Obtained by Different Extraction Methods
Authors: Rial Rafael , Merlo Thais , Santos Piter , Melo Luiz Felipe , de Freitas Osmar , Barbosa Reginaldo Aparecido , Nazário Carlos Eduardo , Viana Luíz Henrique
Published: November 2022

Cagaiteira, the fruit popularly known as cagaite, belongs to the Myrtaceae family. Seed oil cagaite (Eugenia dysenterica DC) was obtained by three methods of extraction, extraction using an ultrasound (OCU), extraction by mechanical pressing (OCP) and extraction with Soxhlet extractor (OCS) in 3 different times (3, 6 and 9 h) and the content of fatty acids and physicalchemical properties were compared. The rate of saturated fatty acids ranged from 19.46% (OCP03) to 31.18% (OCS09), while the amount of unsaturated fatty acids ranged from 54.72% (OCP03) to 67.64% (OCS09). Linoleic and linolenic acids, important in nutrition food, varied between 32.22- 38.11 and 5.55-8.78%. For oxidative stability, OCUAq (heated ultrasound extraction) samples showed the highest induction periods, showing a positive correlation with antioxidant activity and phenol content, demonstrating the efficiency of the use of ultrasonic extraction to obtain quality oils from cagaite seeds.
Antibacterial Activity and Potential Of Natural Textile Dyes From Sea Water Bacteria
Authors: Syaifudin Andang , Sutrisno Sutrisno
Published: November 2022

This research aims to determine the potential of bacterial isolates from Marina beach seawater to be used as natural textile dyes and to test their antibacterial ability. The media used for culturing bacteria is a zobel synthesis medium with a mixture of seawater. The results of the isolation and extraction of color pigments obtained a red color with a characteristic wavelength of 535 nm and has a variety of chemical content results. Pigment immersion trials using 3 types of fabric, namely cotton, primisima and dobby fabric. The results of immersion with ethanolic solvent obtained optimum results for 12 hours and with the addition of mordant (Fe.H2O4S.7H2O), the color of the fabric is strong enough to withstand washing with detergent and sunlight. From the results of the study, data showed that the dyed primisima fabric gave a reduction or inhibition of the growth of E. coli bacteria by 9% while the inhibition of S. aureus bacteria was 116%. The pigment has the potential to be used as a dye for batik cloth with the provisions of optimizing to find the right reinforcement or mordant. This study has implications for the discovery of red pigment-producing bacteria from the isolation of seawater at Marina Semarang beach.
Synthesis of visible light-responsive cuprous oxide/sunflower stem pith hybrid materials for detoxification of methylene blue
Authors: Liu Xiangyao , Zhang Haili , Jing Guolin
Published: November 2022

The detoxification of dye-contaminated water by photocatalysis has become a research priority. Here, a novel hybrid material, cuprous oxide/sunflower stem pith (Cu2O/SSP), was successfully synthesized in situ, using copper hydroxide gel, prepared by ion exchange, as the precursor to Cu2O. The presence of Cu2O nanoparticles on the SSP was confirmed by scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction analyses. Using methylene blue (MB) as the target pollutant, Cu2O/SSP delivered excellent adsorption–photocatalytic degradation and was readily photoregenerated. Cu2O/SSP removed 72.7% of MB after 60 min under visible light irradiation, an increase of 15.6 % compared with unmodified SSP. SSP plays three roles in the removal of MB: it acts as an adsorbent for the MB, a carrier for the Cu2O nanoparticles and it also inhibits photocorrosion of Cu2O. The mechanism of adsorption–photocatalysis by Cu2O/SSP was investigated and a description of the mechanism is provided. This study paves the way for the detoxification of dye-containing wastewater using hybrid biomass materials.
Mais do que a união das partes: a unidade do Estado e o problema do pluralismo em Carl Schmitt
Authors: Passos Eduardo , Benjamin Cássio
Published: November 2022

Este artigo tem como objetivo explicitar a complexa relação entre unidade e pluralismo no pensamento político de Carl Schmitt. Tal discussão será feita a partir dos textos O Conceito do Político (Der Begriff des Politischen) e Staatsethik und pluralistischer Staat. Se por um lado, Schmitt confronta-se com a realidade pluralista das sociedades contemporâneas e com o perigo do deslocamento do político para fora da dimensão do Estado, por outro lado, o jurista insiste na procura por uma unidade substancial que transcenda o mero acordo entre as diferentes associações e grupos que compõem a sociedade.
O caráter político da jurisdição constitucional: uma abordagem a partir de Carl Schmitt
Authors: Ladeira de Oliveira Cláudio
Published: November 2022

Neste artigo, analiso o modo como Carl Schmitt define a natureza política da jurisdição constitucional a partir de seus trabalhos redigidos nos anos derradeiros da República de Weimar: “O Conceito do Político” e “O Guardião da Constituição”. Tento contrastar suas respostas com abordagens algumas contemporâneas. Em especial, sua tese sobre a diferença entre a “alta política” e “política secundária” são imprescindíveis para compreender sua defesa de uma concepção de Estado de Direito respeitosa à “separação de poderes” e sua posição quanto à criação judicial do direito no âmbito da jurisdição ordinária. Corretamente compreendidas, suas teses são de enorme pertinência em contextos marcados simultaneamente por crises políticas-institucionais e intensa judicialização da política
Concentration-mediated Folding and Unfolding of Collagen Triple Helix
Authors: Sun Xiuxia , Xiao Jianxi , Fu Caihong , Li Wenhua
Published: November 2022

Background:

Collagen has been widely utilized in tissue engineering, regenerative
medicine and cosmetics. Collagen of low concentrations is frequently applied to reduce the production
cost, while it may result in the loss of triple helical structure and bioactivity. CD and NMR techniques
have enhanced our understanding of collagen triple helix, while they require high concentrations of
collagen samples.

Objective:

We have systematically investigated the folding and unfolding features of collagen mimetic
peptides at a broad variety of concentrations in order to decipher the role of the concentration in the
triple helical stability.

Methods:

Peptide FAM-G(POG)10 was synthesized by the solid phase synthesis method. Fluorescence
spectra of peptide FAM-G(POG)10 at different concentrations were recorded. The unfolding and
folding profiles of peptide FAM-G(POG)10 with concentrations varying from 1 nM to 100 μM were
examined. The effect of concentration on the folding and unfolding capability of peptide FAMG(
POG)10 was investigated.

Results:

Fluorescence characterization of peptide FAM-G(POG)10 under widely varying concentrations
from 1 nM to 100 μM has revealed that concentration played a critical role in the stability of collagen
peptides. The two-phase pattern of the concentration-dependent folding and unfolding curves has for
the first time demonstrated the presence of a critical concentration for the collagen peptide to trigger
the complete folding of the triple helix and to maintain the triple helix structure. It is noteworthy that
the triple helix structure of collagen peptides was very stable at μM-level concentrations from both the
folding and unfolding perspectives.

Conclusion:

It has significantly contributed to our understanding of collagen triple helix stability at
low and ultra-low concentrations, and provided valuable and practical guidelines for the preparation of
collagen-based products.