bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable Development of Business with Canvas Business Model Approach: Empirical Study on MSMEs Batik Blora, Indonesia
Authors: Widjajanti Kesi , Prihantini Febrina Nafasati , Wijayanti Ratna
Published: June 2022

MSME Batik Blora in running their own business, they are equally weak in terms of human resources (HR), innovation, capital, technology and marketing. Therefore, government policies related to strengthening MSME businesses need to be supported by implementing an effective business planning model. One of the business planning models that can be applied to the Blora batik business is the Business Model Canvas (BMC). The purpose of this study is to identify the application of the canvas business model as an effort to develop batik SMEs in a sustainable manner. This research is a qualitative research based on empirical findings in the field. This research was conducted on Batik UMKM which is located in Blora Regency as one of the unique batik producing centers in Indonesia. The data used in this study is primary data collected by observation, in-depth interviews and also focus group discussions. The sources of data in this study are related stakeholders such as SMEs in Blora Batik, Blora Regency Government, Academic Experts on Batik and MSME Policy, Banking, and also community institutions. The data analysis used in this research is triangulation. The results show that the canvas business model for Batik UMKM in Blora focuses on the Customer segment, Value proposition, Key resources and Key partners. The implication of this research is that UMKM Batik is one of the businesses that needs to be developed because it is a local wisdom that has uniqueness and characteristics that can be added value for the market. The development of MSMEs Batik can be one of the pioneers for providing community employment so that it helps improve the economy.
INNOVATSION YONDASHUV ASOSIDA BO’LAJAK BOSHLANG’ICH SINF O’QITUVCHILARIGA TARBIYA DARSINI TASHKIL ETISH
Authors: BERDIBEKOVA Feruza
Published: June 2022

Tarbiya jarayoni ko’p qirrali jarayon bo’lib, unga tarbiya mohi-yatini yoritishga xizmat qiluvchi ichki va tashqi (subyektiv va obyektiv) omillar ko’zga tashlanadi. Subyektiv omillar shaxsning ichki ehtiyojlari, qiziqishlari, hayotiy munosabatlarini anglashga yordam bersa, obyektiv omillar shaxsning hayot kechirishi, shakllanishi, hayotiy muammolarni ijobiy hal etish uchun sharoit yaratadi. Tarbiya faoliyatining mazmuni, yo’nalishi va shakli obyektiv sharoitlar bilan qanchalik mutanosib kelsa, shaxsni shakllantirish borasida shunchalik muvaffaqiyatga erishiladi. Tarbiya jarayonining tashkil etilishi va boshqarilishida nafaqat o’qituvchi faoliyati, balki o’quvchining yosh va psixologik xususiyatlari, o’y-fikrlari, hayotiy qarashlari ham muhim o’rin tutadi.
A Systematic and Quantitative Method to Measure the Achieved Program Learning Outcomes in Higher Education
Authors: Naim Nasser Ramzi , Sayed Mohd Biju Theruvil
Published: June 2022

This study calculates the level of academic program learning outcomes achieved through a course/module/unit within a higher education institution. The study draws on hypothetical data (secondary data), of a computer science course. The approach of the study demonstrates an empirical, reliable, and robust method to measure the level of program learning outcomes delivered and achieved. The method to calculate the level of learning outcomes uses a graded hypothetical assessment, charted in a specification table. The percentage covered is the ratio of the course learning outcome covered by the assessment then multiplied by the probability of a course learning outcome to occur in program learning outcome. The method is based on several specification table alignments between course learning outcomes and program learning outcomes. Embedded in the specification tables is assessment data that reflect what is covered and achieved of the curriculum. The originality of this study is that it posts a robust methodology to calculate objectively the achieved learning outcomes. The findings lead us to think in new ways to reconceptualize how students are assessed in higher education. Thus, rather than assess students on how they achieve on course tests and other tasks; students can be assessed on the learning outcomes they have achieved.
The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis
Authors: Moradi Yousef , Soheili Marzieh , Dehghanbanadaki Hojat , Moradi Ghobad , Moradpour Farhad , Mahdavi Mortazavi Seyede Maryam , Gilzad Kohan Hamed , Zareie Mostafa
Published: June 2022

Purpose: Patients with HIV may be more likely to become severely ill from COVID-19. The present meta-analysis aims to determine the impact of HIV/AIDS infection on the clinical outcomes of COVID-19. Methods: A comprehensive literature search was performed to identify relevant cohort studies to evaluate the association of HIV/AIDS infection with clinical outcomes of COVID-19. International databases, including PubMed (Medline), Web of Sciences, Scopus, and Embase, were searched from the emergence of the COVID-19 pandemic until January 2022. We utilized the risk ratio (RR) with its 95% confidence interval (95% CI) to quantify the effect of cohort studies. Results: Twelve cohort studies were included in this meta-analysis, which examined a total number of 17,786,384 patients. Among them, 40,386 were identified to be HIV positive, and 17,745,998 were HIV negative. The pooled analyses showed HIV positive patients who were co-infected with SARS-CoV-2 were 58% more likely to develop a fever (RR=1.58; 95% CI: 1.42, 1.75), 24% more likely to have dyspnea (RR=1.24; 95% CI: 1.08, 1.41), 45% more likely to be admitted to ICU (RR=1.45; 95% CI: 1.26, 1.67), and 37% more likely to die from to COVID-19 (RR=1.37; 95% CI: 1.30, 1.45) than HIV negative patients. Conclusion: HIV/AIDS coinfection with COVID 19 increased the risk of fever, dyspnea, ICU admission, and mortality.
Effective Supreme Auditing Institutions, Sound Public Finance Management and National Development: Lessons for Zimbabwe’s Office of Auditor General
Authors: Muzurura Joe , Mutambara Emmanuel
Published: June 2022

Numerous reports on systemic public corruption, fraud, illicit financial outflows, and corporate mis-governance in Zimbabwe’s public sector have brought the effectiveness of the country’s supreme audit institution under intensive public foci. There are now urgent calls for the country’s supreme audit institution to go beyond the traditional compliance-oriented cynosure by addressing challenges in the public sector that are encumbering national development. The aim of the paper is to interrogate with the aid of structural equation modelling the relationship among an effective supreme auditing institution, national development, and sound public finance management. Data was collected using a structured questionnaire administered on a multi-stage cluster sample of 210 public officials in Zimbabwe’s public sector. We found the relationship among three statistically significant at 99% level of confidence implying that increasing audit effectiveness has both feedback and feedforward effects on sound public finance management and, national development. Strategies that enhance auditor independence, public sector financial accountability and public trust have been recommended for a robust public finance management and sustainable national development.
Maternal Anxiety, Depression, Alexithymia, and Social Support: Association With Maternal-Fetal Attachment in Pregnancy
Authors: Ierardi Elena , Bottini Marta , Facchinetti Melania , Crugnola Cristina Riva
Published: June 2022

BACKGROUND

Maternal-fetal attachment (MFA) is the emotional bond between a mother and her fetus and is influenced by numerous risk and protective factors during pregnancy. However, according to the literature, the results relating to the influence of these factors are mixed.

METHOD

The aim of the study is to identify the relationship between MFA and maternal distress, evaluated as maternal depression and anxiety, alexithymia, and perceived social support during the prenatal period in an Italian community sample. Ninety-four pregnant women completed self-report questionnaires.

RESULTS

Results showed that total MFA was negatively associated with maternal anxiety and alexithymia and was positively associated with social support. Moreover, maternal depression was negatively associated with the quality subscale of MFA The quality subscale of MFA was negatively associated with maternal state and trait anxiety and alexithymia and was positively associated with social support. The intensity subscale of MFA was positively associated with social support. Multiple regression showed that alexithymia and social support predicted MFA with a higher effect than maternal depression and anxiety.

CONCLUSIONS

The results are useful for planning interventions aimed at supporting the mother-infant bond starting from pregnancy.
The predictive role of preoperative full blood count markers and the De-Ritis ratio in the diagnosis of testicular tumor
Authors: HABERAL Hakan Bahadır Haberal , SARIKAYA Kubilay , SADİOĞLU Fahri Erkan , İBİŞ Muhammed Arif , ŞENOCAK Çağrı , BOZKURT Ömer Faruk
Published: June 2022

Aim: To determine the value of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), systemic immune-inflammation (SII) index and De-Ritis ratio, which are among preoperative whole blood and biochemical parameters, in the diagnosis of testicular tumor.
Materials and Methods: The data of patients who underwent inguinal orchiectomy for testicular tumor in our clinic between October 2010 and December 2019 and patients who underwent varicocelectomy, as a control group, were retrospectively analyzed. Patients with missing data, under 18 years of age or with additional morbidity were excluded from the present study. Prediction values for NLR, PLR, LMR, SII index and De-Ritis ratio were determined and the value of these parameters in the diagnosis of testicular tumor was examined.
Results: Thirty-four (14.1%) patients underwent inguinal orchiectomy while 207 (85.9%) patients underwent varicocelectomy in the present study. The median age of the patients during surgery was 27 (23-32) years. The number of patients with seminoma, mixt germ cell tumor, yolk sac tumor and embryonal carcinoma was 18 (52.9%), 12 (35.3%), 3 (8.8%) and 1 (2.9%), respectively. It was determined that 61.8% of the patients with testicular tumors were in the T2 stage and 35.3% had metastasis. The cut-off values for NLR, PLR, LMR and SII index were determined as 1.76, 133.43, 7.81 and 571.63, respectively. There was no statistically significant cut-off value for De-Ritis ratio (p = 0.183). The only significant factor for predicting testicular tumor was SII index in multivariate analysis (p <0.001).
Conclusion: SII index is a predictive factor that can be used in the diagnosis of testicular tumor.
The Substantial Basis of Russian Identity. Regional and Ethnocultural Сontexts : [monography]
Authors:   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation, Drobizheva Leokadiya M. , Arutynova Ekaterina M. ,   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation, Evseeva Mariya A. ,   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation, Kuznetsov Igor M. ,   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation, Ryzhova Svetlana V. ,   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation, Fadeev Pavel V. ,   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation, Shchegolkova Elena Y. ,   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation, Endryushko Anna A. ,   Institute of Sociology FCTAS RAS, Moscow Russian Federation
Published: June 2022

Книга посвящена анализу того, какие смыслы люди разных национальностей и социального положения осознают, идентифицируя себя с гражданами России. На базе общероссийского опроса по репрезентативной выборке, нескольких региональных опросов, экспертных и глубинных интервью и фокус-групп изучены ключевые компоненты российской идентичности – гражданская составляющая, русский язык, история, культура, представления о том, что такое «наша страна», а также эмоции и чувства россиян по отношению к ней. Отдельно рассмотрено межэтническое согласие как ресурс российской идентичности. Проанализированы смыслы российской идентичности во властном дискурсе и в пространстве школьного образования. Книга будет интересна специалистам, работающим в сфере регулирования межэтнических отношений, преподавателям школ и вузов, студентам и аспирантам, а также всем интересующимся вопросами российской идентичности и межэтнических отношений.
Kulturowa (nie)przetłumaczalność emocji w języku — na przykładzie emocji negatywnych
Authors: Łukaszewicz Barbara
Published: June 2022

The article considers the possibility of translating the names of emotions into other languages, taking into account cultural and sociolinguistic factors. Based on the concepts created by researchers in traductology (e.g. John C. Catford) or cultural linguistics (e.g. Anna Wierzbicka), it has been shown that the names of emotions can be perceived as untranslatable, especially in the context of searching for their one-word equivalents in other languages. Attention was paid to such names, the meaning of which is closely related to the culture of a given society (e.g. historical events) and therefore they should be classified as the so-called mentifacts, defined by Donald W. Klopf as affective and cognitive factors shaping the perception of the world by a given community. The proposed way of explaining the meanings of the names of emotions is the description of exemplary situations as a result of which they arise or with which they are commonly associated in a given society. In the summary, it was emphasized that the names of emotions are keywords with which you can learn not only a foreign language, but also culture.
Türkiye’de illere göre birinci doz Covid-19 aşı kapsayıcılık hızı ile haftalık Covid 19 insidansı arasındaki korelasyonun değerlendirilmesi
Authors: ERDAL Deniz , ŞAŞMAZ Caferi Tayyar
Published: June 2022

Amaç: Bu çalışmada, Sağlık Bakanlığı tarafından, periyodik ve topluma açık olarak yayınlanan, Covid-19 aşılamasına ait birinci doz aşı kapsayıcılık hızları ile haftalık vaka insidansları arasındaki korelasyonun değerlendirilmesi amaçlanmıştır. Yöntem: Bu çalışma Ekolojik bir çalışma olarak planlandı. Sağlık Bakanlığı tarafından web sayfası üzerinden yayınlanan, illere göre haftalık Covid-19 insidansı ve 18 yaş üzerinde birinci doz Covid-19 aşı kapsayıcılık hızı verilerinin analizleri bilgisayar ortamında yapılmıştır. İlk insidans verisi 10-16 Temmuz 2021 haftasında, son veri 04-10 Eylül 2021 haftasında alınmıştır. Haftalık insidans ve kümülatif birinci doz aşı kapsayıcılık hızları parametrik test koşullarını sağlamadığından Spearman korelasyon analizi yapılmıştır. Bulgular: 10-16 Temmuz 2021 haftasında illere göre Covid-19 vaka insidansı ile birinci doz aşı kapsayıcılığı arasında korelasyon katsayısı rho=-0.314 olarak hesaplanmıştır. Hesaplanan korelasyon negatif yönlü ve zayıf bir korelasyon olup, istatistiksel olarak da anlamlıdır (p
MENGGAGAS KONSEP PENERAPAN SHARIAH COMPLIANCE AUDIT: SEBUAH UPAYA PENCAPAIAN ISLAMIC CORPORATE GOVERNANCE
Authors: Prakosa N. Iman , Zuchri Lutfi
Published: June 2022

This research is aimed to give solution over the imbalance that happened between the practices that shariah business entities actually do and those that should be done. This research will formulate an ideal concept regarding shariah compliance audit which involves independent party outside the company structureâ€”the independent party suggested in this research is Certified Shariah Public Accountant (APSB)â€”who will assess the fairness of shariah business entity practices in accordance with Indonesian Generally Accepted Principals of Shariah Business Practices (PPBSBUI). Then hopefully there would be no more public deception upon â€œshariahâ€ label on shariah business entities and the islamic corporate governance on shariah business entities will be accomplished as well.
KEBUTUHAN DAN TANTANGAN AUDIT SYARIAH DAN AUDITOR SYARIAH
Authors: Nugraheni Peni
Published: June 2022

Audited financial statement is the ways to make sure that information available on that report can be used to make decision, because there is an opinion of independent person (auditor) whether it presents a true and fair view of the company or not. Islamic bank established Shariah Supervisory Board (SSB) that one of its functions is to issue report about the compliance of Islamic bank in all activities with Islamic principles. This report is published with the external auditorâ€™s annual report. Islamic bank is common to hire conventional auditor to audit its financial statements. However, because of the unique characteristics of Islamic bank, the using conventional auditor raises an issue whether it is adequate to audit and report on the accounts of an Islamic organization. By understanding the Islamic value, characteristics, activities, operation and normative content of Islamic banking report, this paper argues that conventional auditors is not adequate in both his knowledge and code of ethics, and therefore, the need for shariah audit become important for this institution. Shariah audit program, shariah audit qualification and education and independence of shariah auditor are the challenges to create qualified shariah auditors.
Recommendations for collection and development strategy of waqf funds: A case study on waqf institutions
Authors: Hasan Putri Purwandari , Shauki Elvia R.
Published: June 2022

Purpose – This study aims to examine phenomena related to the collection and development of waqf funds by waqf institutions and formulate recommendations regarding applicable strategies to optimize the collection and development of waqf funds based on the principles of commitment-trust theory.Methodology – This study applied a case study approach with a qualitative method at 5 (five) different waqf institutions in Indonesia to further explore the phenomena related to the collection and development of waqf funds. Data was collected through semi-structured interviews.Findings – The results of this study indicate that several problems, i.e. low literacy of waqf, lack of professionalism of nazhir, and low accountability of waqf institutions are still encountered by waqf institutions in collecting and developing waqf funds. In addition, the efforts made by waqf institutions have not been sufficiently qualified to foster waqif’s commitment and trust to optimize the collection and development of waqf funds. Therefore, several recommendations on applicable strategies for waqf managers are formulated based on the four precursors outlined in the commitment-trust theory, namely shared values, relationship benefits, communication, and non-opportunistic behavior. These recommendations include reaffirming the values of waqf institutions, making efforts to maintain good relations with waqifs, keeping good communication with waqifs, and improving transparency of financial reports.Originality – This study complements the research gap of the limited studies on the collection and development of waqf funds. In addition, previous studies on this topic did not implement the commitment-trust theory.
Liquidity risk in economic uncertainty: Evidence from Indonesian Islamic banks
Authors: Anis Muhammad , Hamdi Baitul
Published: June 2022

Purpose – This paper aims to analyze the effect of economic uncertainty on liquidity risk of Islamic banks in Indonesia by observing the impact of economic uncertainty (World Uncertainty Index), macroeconomic factors (GDP Growth and Inflation Rate), and bank-specific factors (CAR and ROA) on liquidity risk.Methodology – Using time-series quarterly data from OJK’s Islamic Banking Statistics 2015-2021, this research applies Auto-Regressive Distributed Lag (ARDL) and Error Correction Term (ECT) to see the long-term impact and short-term response of economic uncertainty, inflation rate, GDP growth, ROA and CAR on liquidity risk of Islamic Bank.Findings – This research finds that economic uncertainty has a positive and significant effect on liquidity risk in the short term and long term. It means the increase in uncertainty index caused by the crisis, war, or pandemic like nowadays will enhance the liquidity risk of Islamic banking. At the same time, the inflation rate has a significant negative effect on liquidity risk in the short-term and long term.Originality – This research uses a combination of macroeconomic variables and bank-specific factors, and the economic uncertainty variable from the World Uncertainty Index. In this case, one of the reasons for liquidity problems apart from fund management failure is unfavorable economic conditions. In addition, this study also provides several recommendations in maintaining banking liquidity risk.Research limitations – This study uses time-series data with a limited period (2015Q1-2021Q2). In addition, this uses cumulative data on Islamic banking in Indonesia; thus, it does not describe the conditions in each Islamic bank, although certainly there are some different conditions between each other. Therefore, it is hoped that studies will complement these limitations in the future.
Characterization of the Nuclear Proteome of Chlamydomonas in Response to Salt Stress
Authors: Magalhães Larissa de Oliveira , Nunes de Mello Fabio , Vischi Winck Flavia
Published: June 2022

Microalgae biomass is considered a promising alternative feedstock for biodiesel production due to its high productivity of neutral lipids, specially under abiotic stress conditions. Among the unicellular microalgae that show this characteristic, Chlamydomonas reinhardtii appears as one of the most important model species that have increased lipids production under abiotic stress conditions. In this study, we show that cells cultivated under mixotrophic condition supplemented with 0.1 M of NaCl rapidly raises their amount of neutral lipids in C. reinhardtii without reduction of their cellular growth rate, being therefore a promising condition for biomass towards bioenergy production. The nuclear proteome of these cells was investigated where we identified 323 proteins with an enrichment of almost 60% of nuclear proteins in the total dataset. We found 61 proteins differentially regulated upon salt treatment, including proteins annotated in functional categories related to translation and nucleosome assembly functions, among others. Additionally, we identified Transcription factor proteins (TFs) and analyzed their likely Transcription factors-binding regulatory elements identifying target genes related to lipids metabolism and kinase functions, indicating possible regulatory pathways of lipids biosynthesis. Together these data can help understand regulatory nuclear mechanisms leading to an increase of lipids in the first 24h of salt stress 0.1M NaCl.
Effectiveness of High-Intensity Interval Training and Continuous Moderate-Intensity Training on Blood Pressure in Young Physically Inactive Pre-Hypertensive Adults
Authors: John Anil T , Chowdhury Moniruddin , Islam Rabiul , Mir Imtiyaz Ali , Hasan Md Zobaer , Chong Chao Yi , Humayra Syeda , Higashi Yukihito
Published: June 2022

The likelihood of a pre-hypertensive young adult to develop hypertension has been steadily increasing over the past few years. Aerobic exercise training (AET) has been found to reduce high blood pressure, however, efficacy of different types of aerobic exercise is yet to be determined among the pre-hypertensive young adults. The objective of this study was to evaluate the effectiveness of high-intensity interval training (HIIT) and continuous moderate-intensity training (CMT) on blood pressure (BP) in young physically inactive pre-hypertensive adults. 32 adults (age 20.0±1.1) were randomly assigned into 3 groups; HIIT, CMT, and control (CON). HIIT and CMT groups participated in 5 weeks of AET with CON group not participating in any exercise. The HIIT protocol consisted of 1:4 minute work to rest ratio of participants 80%-85% heart rate reserve (HR-reserve) and 40%-60% HR-reserve respectively for 20 minutes, CMT group exercised at 40%-60% of HR-reserve continuously for 20 minutes. In both HIIT and CMT groups, systolic blood pressure (SBP) (3.8±2.8 mmHg, P=0.002 VS 1.6±1.5 mmHg, P=0.011) was significantly reduced. While, significant reductions were noted in the diastolic blood pressure (DBP) (2.9±2.2 mmHg, P=0.002) and mean arterial pressure (MAP) (3.1±1.6mmHg, P<0.0005) only in the HIIT group. No significant difference in SBP (-0.4±3.7 mmHg, P=0.718), DBP (0.4±3.4 mmHg, P=0.714), or MAP (0.1±2.5mmHg, P= 0.892) was observed in the CON group. Both HIIT and CMT decreased the BP in physically inactive pre-hypertensive young adults; however, HIIT yielded more beneficial results in terms of reducing the SPB, DBP, and MAP.
An Exploration of A Reflective Evaluation Tool for the Teaching Competency of Pre-Service Physical Education Teachers in Korea
Authors: chul-min kim , eun-chang Kwak
Published: June 2022

The purpose of this study was to develop a reflective evaluation tool that can enhance the teaching competency of pre-service physical education teachers. A Delphi survey was conducted to modify the questions based on the evaluation tool for the teaching competency of physical education teachers, and each evaluation standard based on teaching competency was developed. The evaluation tool consisted of 46 questions for class preparation (the creation of the learning environment), the introduction (routine activities, learning goals, and task presentation), development (class strategy, observation and interaction, and the maintenance of the learning environment), and conclusion (routine activities, summary, and closure). It was designed to increase the accuracy of evaluation by developing evaluation criteria for each question. An evaluation tool including quantitative and qualitative methods for use in pre-service physical education teacher education was developed. The significance of this study was the development of an effective evaluation tool that can evaluate the core teaching behaviors in the field of physical education. This evaluation tool should be used as a learning tool that includes planning, operation, evaluation, and seeking improvement measures through reflective activities. If pre-service teacher education institutions apply this evaluation tool in their teacher training programs, it would be a great chance to learn how to develop and sustain teaching abilities and effectiveness.
Using Social Media to Build the Loyalty Loop in Omnichannel Retail
Authors: Cattrall David , Castello Simone
Published: June 2022

Customers make purchases through a multi-stage, omnichannel process, which now extends to social media. A loyalty loop can be achieved when an existing customer bypasses the initial stages –consider and evaluate– to make a direct purchase. However, to build that loyalty loop, a retailer must embrace techniques and software across social media marketing, social CRM, and omnichannel CRM. Reviewing literature from academic researchers and industry practitioners, this paper identifies emerging industry trends and discusses an illustrative case study of a UK digital retailer. The importance of social media for omnichannel retailing and building loyalty is highlighted and discussed.
Latently Activated Granulocytes From an Autoimmune Uveits Model Show Divergent Pathway Activation Profiles Upon IL8 Stimulation in vitro
Authors: Hoffmann Anne L.C. , Hauck Stefanie M. , Deeg Cornelia A. , Degroote Roxane L.
Published: June 2022

In the pathophysiology of autoimmune-mediated uveitis, granulocytes have emerged as possible disease mediators and were shown to be latently activated in equine recurrent uveitis (ERU), a spontaneous disease model. We therefore used granulocytes from ERU horses to identify early molecular mechanisms involved in this dysregulated innate immune response. Primary granulocytes from healthy and ERU horses were stimulated with IL8 and cellular response was analyzed with differential proteomics, which revealed significant differences in protein abundance of 170 proteins in ERU. Subsequent ingenuity pathway analysis identified three activated canonical pathways “PKA signaling”, “PTEN signaling” and “leukocyte extravasation”. Clustered to the leukocyte extravasation pathway, we found the membrane-type GPI-anchored protease MMP25, which was increased in IL8 stimulated ERU granulocytes. These findings point to MMP25 as a possible regulator of granulocyte extravasation in uveitis and a role of this molecule in the impaired integrity of the blood-retina-barrier. In conclusion, our analyses show a clearly divergent reaction profile of latently activated granulocytes upon IL8 stimulation, and provide basic information for further in-depth studies on early granulocyte activation in non-infectious ocular diseases. This may be of interest for development of new approaches in uveitis diagnostics and therapy. Raw data are available via ProteomeXchange with identifier PXD013648.
Indonesia Female Principal Performance Appraisal: Gender Perspective
Authors: Widyawati Rahma , Widowati Anik Sri , Maemunah Mei , Istiningsih Istiningsih , Nurnilawati Eny , Kurnianingsih Widiyanti
Published: June 2022

Research Aims: This study aimed to determine the direct influence of communication style and individual competence on female principals' empowering leadership and performance in Yogyakarta, Indonesia. Design/methodology/approach: The respondents of this study were 220 teachers from 3 accredited high schools with female principals in Yogyakarta, Indonesia. The questionnaire was analysed using structural equation modelling with AMOS to determine the relationship between variables and using Sobel Test to test leadership as a mediating variable. Research findings: The results of this study show that communication style and competence have a positive and significant effect on leadership and performance, leadership has a significant effect on performance, and leadership acts as a mediating variable. The results also indicate that gender acts as a moderating variable by strengthening the relationship between leadership and principal performance. Theoretical Contribution/Originality: The contribution of this study is to develop and examine the direct and indirect relationship between communication style, competence, gender, leadership, and performance of principals. Managerial Implication in the South East Asian Context: The results of this study can help principals design effective leadership development programs by selecting the appropriate leadership style to improve the performance of school principals. Research limitation & Implications: This research is limited by the number of respondents and the number of predictor variables of leadership and performance. This research has important implications for future research on the joint effects of contextual factors, personal characteristics, and social network attributes in the gendering leadership in the education sector. Keywords: communication style, competence, gender, leadership, performance
Drivers and Outcome of Motivation to Improve Work Through Learning: Evident from South East Asia
Authors: Ithnin Nor Shamri , Ismail Md Daud , Ismail Azman
Published: June 2022

Research Aims: This study aims to examine the influence of social support on training transfer and investigate the mediating effect motivation to improve work through learning has on this relationship. Design/Methodology/Approach: This study used a quantitative design, utilising a cross-sectional survey via self-administered questionnaires, with experienced firefighters as respondents. Out of the 500 questionnaires received, 395 were valid responses and were further analysed using statistical analyses, such as confirmatory factor analysis and structural equation modelling. Research Findings: While peer support is a strong driver of training transfer, supervisor support has no significant influence on training transfer. Also, motivation to improve work through learning mediates the effect of social support on training transfer. Ample support from supervisors and peers to employees at work enhances employees’ motivation to improve work through learning and leads to applying the acquired knowledge, skills and abilities. Theoretical Contribution/Originality: This study provides evidence that human resource administrators should enhance the social support provided to employees to ensure that the new knowledge, skills and abilities acquired via training programmes are utilised on the job. Managerial Implications in the South East Asian Context: Social support is critical in public or private organisations. Adequate support to employees is needed to enable employees to benefit from the newly acquired knowledge, skills and attitudes gained through training. However, social support alone is insufficient without considering employees’ motivation to improve performance. Employees’ motivation to improve work through learning must be emphasised when promoting positive training transfer in organisations. Research Limitation & Implications: The cross-sectional approach and single informant limit the generalisability of the findings. Since the present study sample was drawn from one country and a single organisation, future studies could replicate the research in other countries and various organisation types to enrich the findings. Keywords: social support, supervisor support, motivation to improve work through learning, training transfer
Bibliometric Analysis The Effect of Health Protocol Social Marketing Communications on New Adaptations Covid-19 Pandemic
Authors: Winardi Moch Bima Syaputra , Rohman Muhammad Chabibur , Rasyid M Yusach Ryadh , Putra Andre Astana , Dharma Ferry Adhi
Published: June 2022

The bibliometric approach is an analysis carried out with the aim of developing scientific fields taken from the analysis of previous journals or articles selected through the Web of Science, Scopus, Google Scholar and Semantic Scholar. The purpose of using bibliometric analysis is to find out how many journals with the theme of the influence of social marketing communication on health protocols on new adaptations during the covid-19 pandemic. The purpose of this study is to measure the depth of public awareness regarding the application of health protocols during the COVID-19 pandemic. With the elements contained in social marketing communication theory, it can increase knowledge and change people's behavior regarding the application of health protocols during the covid-19 period. The method for measuring the quantity of publications is done by taking data from Google Scholar and Semantic Scholar then analyzed using Vos viewer. The results of the visualization will be explained in detail through theoretical dialogue and the results of bibliometric analysis from journal publications with keywords Bibliometrics, Social marketing communication, Health protocols, Covid-19 can be additional references and research can be developed more broadly.
Footwear and insole design parameters to prevent occurrence and recurrence of neuropathic plantar forefoot ulcers in patients with diabetes; - A series of N-of-1 trials study protocol.
Authors: Ahmed Sayed , Butterworth Paul , Barwick Alex , Hasan Md Zobaer , Nancarrow Susan , Sharma Anita
Published: June 2022

Background Foot complications occur in conjunction with poorly controlled diabetes. Plantar forefoot ulceration contributes to partial amputation in unstable diabetics, and the risk increases with concomitant neuropathy. Reducing peak plantar forefoot pressure reduces ulcer occurrence and recurrence. Footwear and insoles are used to offload the neuropathic foot, but the success of offloading is dependent on patient adherence. This study aims to determine which design and modification features of footwear and insoles improve forefoot plantar pressure offloading and adherence in people with diabetes and neuropathy.MethodsThis study, involving an N-of-1 trial, included 21 participants who had a history of neuropathic plantar forefoot ulcers. Participants will be recruited from three sites, including two high-risk foot services and a private podiatry clinic in Sydney, Australia. MatScan and F-Scan plantar pressure mapping systems by TekScan (Boston, USA) will be used to measure barefoot and in-shoe pressures. Participant's self-report will be used to quantify the wearing period over a certain period of between two to four weeks during the trial. Patient preference toward the footwear and insoles design and quality-of-life related information will be collected and analysed. The descriptive and inferential statistical analyses will be performed using IBM SPSS Statistics (version 27). And the software NVivo (Version 12) will be utilised for the qualitative data analysis.DiscussionThis is the first trial assessing footwear and insole interventions in people with diabetes by using an N-of-1 trial. Reporting self-declared wearing period and participant's preferences on footwear style and aesthetics are the important approach for this trial. Patient-centric device designs are the key to therapeutic outcomes, and this study is designed with that strategy in mind.Trial registrationThis trial has been registered with the Australian New Zealand Clinical Trials Registry (ANZCTR), and the registration number is ACTRN12620000699965p.
Pattern of forage ingestion of sheep in native field with access to summer legume
Authors: Kroning Alexsandro Bahr , Ferreira Otoniel Geter Lauz , Gruppelli Joice Rodal , Nunes Luiza Padilha , de Oliveira Allan Patrick Timm , Farias Pâmela Peres , Costa Pablo Tavares
Published: June 2022

The objective of this work was to evaluate the effect of access to perennial peanut (Arachis pintoi) pasture on patterns of forage intake and rumination of sheep in native field. The treatments were exclusive grazing in native field (NF) and grazing in native field with free access to perennial peanut pasture (NF+PP), using four test animals for each area, with offer adjusted to 12% of body weight. Rumination, grazing, and idle time were evaluated, beyond to forage ingestion and forage mericic chewing rates. Grazing time during the diurnal period did not have significant differences between the treatments, but a shorter grazing time was observed during the morning when the animals had access to perennial peanut. Grazing and rumination times were negatively correlated with idle time. In the NF+PP treatment, the animals dedicated 18.00% of the daytime period to rumination, while in the NF treatment it was 26.25% of the daytime. With access to forage legumes, there was a decrease in grazing time and an increase in the rumination time of sheep compared to animals kept exclusively in native fields with the same forage allowance. Animals kept in native field and native field with free access to perennial peanut have similar grazing times throughout the day, but with differences between shifts. The animals show preference for perennial peanut, grazing most of time in this area. The longer grazing time on forage peanuts reduces the rumination time of sheep.
A blockchain-based log storage model with efficient query
Authors: Xu Gang , Yun Fan , Yu Yiying , Xu Shiyuan , Chen Xiu-Bo , Dong Mianxiong
Published: June 2022

The server logs play an essential role in website maintenance. When the Internet server is running, the service maintained may encounter various problems, and the logs generated by the server are the key data to locate the problems. However, the existing log storage systems are prone to a single point of failure, which may cause logs to be lost, and the problem cannot be rectified. Meanwhile, external attackers can tamper with logs to evade tracking, and the person in charge of an accident may also tamper with the log to evade responsibility. The advantages of blockchain, such as immutability, decentralization, and security, can effectively overcome these shortcomings. In this paper, we proposed a log data storage scheme based on blockchain and Interplanetary File System (IPFS). The lack of scalability of blockchain for storing large files is addressed by storing the log data stored in IPFS. Firstly, our model uses IPFS to store extensive file log data and combines blockchain technology to realize log data storage decentralization and difficulty to tamper. Secondly, to improve the query efficiency of log data, we propose two improved Merkle tree methods to provide fast queries of log data with a timestamp as query keywords. Finally, the experimental results show that the two methods have better log retrieval efficiency.
Distribution, source finding, and ecological hazard of polycyclic aromatic hydrocarbons and polychlorinated biphenyls in coastal surface sediments of South Pars industrial region (Iran)
Authors: Ghadrshenas Alireza , Tabatabaie Tayebeh , Amiri Fazel , Pazira Abdul Rahim
Published: June 2022

The South Pars Industrial Zone is one of the most important regions in Iran due to the presence of gas, petrochemical, and related industries which is known as Iran’s energy capital. In this study, the effects of pollution made by polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) on coastal sediments were investigated. Ten stations in different places such as vicinities of industries exit flow, ports, shipping terminals, export tanks, beaches and their surface sediments were selected and sampled for analysis in summer and winter in 2019. The samples were tested using the gas chromatography-mass spectrometry (GC-MS) analyzer. Concentrations of Σ PAH and Σ PCB were measured in the range of 26.50–306.45 ng.g-1dw (dry weight) and BDL (below the detection limit) –59.7 ng.g-1dw respectively. There was a significant increase near the outputs of refineries, petrochemicals, and the shipping industry. The ecological risks were reported “low” in all stations for PAH components, except for one station that recorded moderate levels of Acenaphtlen (Ace) and Fluorene (Flu) in the summer. The ecological risks related to PCB components were found to be in low-moderate levels. Three sources were suggested for PAHs: petrogenic (31%), fossil fuel combustion (51%), and biomass/coal combustion (18%). Power plants and wastewater treatment units (34%) and electrical waste disposal sites (66%) were predicted as the main sources of PCBs.It is necessary to prepare and implement a long-term monitoring plan for all outlets to the sea such as electrical waste.
Analyzing Inclusive Green Growth in China: A perspective of relative efficiency
Authors: Zhao Lin , Gao Xiaotong , Jia Jianqi , Zhang Yu
Published: June 2022

Inclusive Green Growth (IGG) has important reference value for China’s ecological civilization construction and transformation of economic development. Therefore, this study assesses China’s IGG level from the perspective of relative efficiency. The IGG efficiency (IGGE) was measured at the provincial level in China from 2000 to 2017 by using super Epsilon-based measure (EBM) model that considers undesirable outputs. The spatiotemporal pattern of IGGE was analyzed by kernel density estimation and spatial autocorrelation. The results indicate a fluctuating trend from 2000 to 2017 for the IGGE of China, and significant differences between regional interprovincial IGGE were observed. On average, the eastern region presented the highest efficiency, while the level in the central and western regions was similar. There is a positive spatial autocorrelation in the IGGE distribution, and the agglomeration of spatial distribution fluctuated during the study period. The IGGE has significant spatial spillover effects at the provincial level according to the spatial Durbin model. Among the influencing factors, the spatial spillover effects of dependence on import and export trade and technological innovation are significant. The regression results also confirm the Environmental Kuznets Curve effect between IGG and economic growth in China. Finally, some implicit policies can be established based on the empirical analysis.
From Laser Speckle to Particle Size Distribution in drying powders: A Physics-Enhanced AutoCorrelation-based Estimator (PEACE)
Authors: Zhang Qihang , Gamekkanda Janaka , Tang Wenlong , Papageorgiou Charles , Mitchell Chris , Yang Yihui , Schwaerzler Michael , Oyetunde Tolutola , Braatz Richard , Myerson Allan , Barbastathis George
Published: June 2022

Extracting quantitative information about highly scattering surfaces from an imaging system is challenging because the phase of the scattered light undergoes multiple folds upon propagation, resulting in complex speckle patterns. One specific application is the drying of wet powders in the pharmaceutical industry, where quantifying the particle size distribution (PSD) is of particular interest. A non-invasive and real-time monitoring probe in the drying process is required, but there is no suitable candidate for this purpose. In this report, we develop a theoretical relationship from the PSD to the speckle image and describe a physics-enhanced autocorrelation-based estimator (PEACE) machine learning algorithm for speckle analysis to measure the PSD of a powder surface. This method solves both the forward and inverse problems together and enjoys increased interpretability, since the machine learning approximator is regularized by the physical law.
Glyceraldehyde-3-phosphate dehydrogenase (PfGAPDH): Design, Isolation, Synthesis and preliminary anti-malarial activity against Plasmodium falciparum 3D7 strains.
Authors: Pierre Yemback Kenneth , Oben Eyong Kenneth , Efange Noella M. , Kamdem Michael HK. , Ndinteh Derek T. , Odumosu Patricia O. , Folefoc Gabriel N. , Ayong Lawrence , Werner Thomas
Published: June 2022

Glyceraldehyde-3-phosphate dehydrogenase (PfGAPDH) for Plasmodium falciparum is a key glycolytic enzyme that catalyzes the conversion of glyceraldehyde 3-phosphate (G3P) into 1,3-bisphosphate glycerate (1,3-BPG), with the concomitant reduction of nicotinamide adenine dinucleotide (NAD+) to NADH. Compounds from the Cameroon Natural Product Library (CANAPL), were screened by molecular docking studies against the enzyme target PfGAPDH. Amongst these docking hits were the lupeol cinnamate (1) and oleanane cinnamate (2) with binding energies (Eb) of -10.55 kcal/mol and − 10.51 kcal/mol respectively, compared to PfGAPDH inhibitors; heptelidic acid (-6.47 kcal/mol), iodoacetate (-3.98 kcal/mol) and pentalenolactone (-6.87 kcal/mol). To validate the docking results, triterpenoids with structural similarities to (1) and (2) were isolated from Baillonella toxisperma (Pierre); olean-12-en-3β-hexadecanoate (3), 3-β-trans cinnamoyloxylup-20(29)-ene (4), oleanoic acid benzoate (5), 3β-amyrin (6), taraxerol (7), betulonic acid (8), β-sitosterol (9), betulinic acid (10), 3β-(trans-p-Coumaroyl)oxylup-20(29)-en-28-oïc acid (11), and screened alongside Betuline (12) and oleanolic acid (13). The favorable compounds 8 and 11 with 100% growth inhibition on Plasmodium falciparum 3D7 strains together with compounds 4, 10 and 12 were structurally optimized to afford new lupane derivatives with the privilege α-β unsaturated carbonyl medicinal scaffolds; - betulonic acid acryl aldehyde (14), betulin acryl aldehyde (15), 3β-(trans-p-Coumaroyl)oxylup-20(29)-en-28-oïc acid acryl aldehyde (16), 30-hydroxy betulinic acid (17), betulinic acid acryl aldehyde (18) and 3-β-trans cinnamoyloxylup-20(29)-ene acryl aldehyde (19) exhibiting more potent anti-malarial activities. Their assays afforded IC50 values of 0.703 µM, 2.15 µM, 1.28 µM, and 3.79 µM for compounds 14, 15, 16 and 18 respectively. These results validate our docking scores and indicate that the modified compounds with the privilege α,β- unsaturated carbonyl medicinal scaffolds could be further optimized into potent antimalarial agents.