bluuebunny/crossref_metadata_2025 huggingface dataset:
Immediate catheter‐directed reperfusion for acute stroke occurring during diagnostic cardiac catheterization
Authors: Chan Albert W. , Henderson Mark A.
Published: January 2006

Acute stroke is a rare but the most dreaded complication of cardiac catheterization. We report a case about the management of an acute stroke that occurred during a diagnostic cardiac catheterization procedure. Immediate catheter‐based intraarterial thrombolysis with adjunctive balloon angioplasty of the left middle cerebral artery was carried out. The patient recovered markedly within the first 2 hr and was discharged without neurological sequelae after 3 days. A clinical pathway for acute stroke management in the catheterization laboratory is discussed.© 2006 Wiley‐Liss, Inc.
Innocent and Less‐Innocent Solvent Ligands: A Systematic Investigation of Cationic Iron Chloride/Alcohol Complexes by Electrospray Ionization Mass Spectrometry Complemented by DFT Calculations
Authors: Trage Claudia , Diefenbach Martin , Schröder Detlef , Schwarz Helmut
Published: January 2006

The influence of anionic and neutral ligands on the reactivity of cationic iron complexes towards methanol, ethanol, and iso‐ and n‐propanol has been investigated by means of electrospray ionization (ESI) mass spectrometry, and in key questions the experimental results are supported by DFT calculations. The chemical processes taking place when FeCl2+ is coordinated to a variable number of alcohol molecules were investigated by collision experiments, as well as reactivity and labeling studies. The most abundant cations formed upon ESI of FeCl3/ROH mixtures can be described as consisting of a covalently bound FeCl2+ core, which is stabilized by neutral ROH ligands, for example, FeCl2(CH3OH)n+. Indications for a hydrogen‐bonding mechanism of ligands in the second coordination sphere are given by the observation of the formally hypercoordinated ion FeCl2(CH3OH)5+ and interpretation of kinetic data for n=4. Further, deuterium labeling experiments disclose a number of hidden hydrogen transfers and imply that complexes with n=1 and 2 can exist in two tautomeric forms. Upon change of the alcohol ligand from methanol to ethanol and propanol, additional reaction pathways become accessible, among which metal‐assisted dehydration of the respective alcohols by means of an ion/dipole mechanism is the most important.
[1,3]‐Transfer of Chirality during the Nicholas Reaction in γ‐Benzyloxy Propargylic Alcohols
Authors: Díaz David D. , Ramírez Miguel A. , Martín Víctor S.
Published: January 2006

A highly regio‐ and stereoselective intramolecular [1,5]‐hydrogen‐transfer process is described. Treatment of γ‐benzyl‐protected Co2(CO)6‐α,γ‐acetylenic diols with BF3⋅OEt2 provides bis‐homopropargylic alcohols. The reaction occurs within seconds, tolerates a wide range of functionalities, and provides good yields. When the ether group is located at a stereochemically defined carbon atom, the rearrangement occurs with high stereoselectivity, transferring the chirality of the carbinol center to the newly created stereocenter. The cleavage of the benzyloxy group is totally regioselective when additional benzyl ethers are present. The scope and limitations of this novel process in densely substituted substrates are evaluated, and possible competitive reactions and/or stereochemical influences are also described. A mechanism based on a highly ordered chair‐like transition state substantiated by a theoretical study is also included.
Facile Preparation of Cyclopropanes from 2‐Iodoethyl‐Substituted Olefins and 1,3‐Dihalopropanes with Zinc Powder.
Authors: Sakuma Daisuke , Togo Hideo
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Acid‐Catalyzed Transformations of 2‐(Phenylethynyl)isoborneol.
Authors: Koval'skaya S. S. , Kozlov N. G. , Dikusar E. A.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Hydroamination/Hydrosilylation Sequence Catalyzed by Titanium Complexes.
Authors: Heutling Andreas , Pohlki Frauke , Bytschkov Igor , Doye Sven
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Iridium‐Catalyzed Carbonyl Allylations by Allylic Alcohols with Tin(II) Chloride.
Authors: Masuyama Yoshiro , Chiyo Toshiya , Kurusu Yasuhiko
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Efficient Synthesis of Arylsulfamides by Reaction of Amines with Arylsulfamoyl Imidazolium Triflate.
Authors: Lee Hyeon Kyu , Bang Miyeon , Pak Chwang Siek
Published: January 2006

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An Efficient Method for the Preparation of Monoalkylated Sulfonamides from Unsubstituted Sulfonamides and Alkyl Diphenylphosphinites by Oxidation—Reduction Condensation Using Trimethylsilylmethyl Azide.
Authors: Aoki Hidenori , Kuroda Kiichi , Mukaiyama Teruaki
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Homocoupling Reactions Using Telluronium Salts.
Authors: Hirabayashi Kazunori , Takeda Yuji , Shimizu Toshio , Kamigata Nobumasa
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Palladium (Phosphinous Acid)‐Catalyzed Cross‐Coupling of Aryl Halides Using a Hypervalent Phenylsilane in Water.
Authors: Lerebours Rachel , Wolf Christian
Published: January 2006

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The First Synthesis of Organic—Inorganic Hybrid Materials with Chiral Bis(oxazoline) Ligands.
Authors: Fraile Jose M. , Garcia Jose I. , Herrerias Clara I. , Mayoral Jose A.
Published: January 2006

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Ring‐Opening Reactions of Diarylvinylidenecyclopropanes by Iodine and Bromine.
Authors: Shi Min , Ma Ming , Shao Li‐Xiong
Published: January 2006

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Rhodium‐Catalyzed Synthesis of Indenols by Regioselective Coupling of Alkynes with ortho‐Carbonylated Arylboronic Acids.
Authors: Shintani Ryo , Okamoto Kazuhiro , Hayashi Tamio
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Antitumor Activity of 1,8‐Diaminoanthraquinone Derivatives.
Authors: Huang Hsu‐Shan , Chiu Hui‐Fen , Lu Wei‐Chih , Yuan Chun‐Lung
Published: January 2006

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A Highly Efficient Procedure for Ruthenium Tetroxide Catalyzed Oxidative Cyclizations of 1,5‐Dienes.
Authors: Roth Stefanie , Goehler Sabrina , Cheng Huan , Stark Christian B. W.
Published: January 2006

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Synthesis of Highly Substituted Furans by the Electrophile‐Induced Coupling of 2‐(1‐Alkynyl)‐2‐alken‐1‐ones and Nucleophiles.
Authors: Yao Tuanli , Zhang Xiaoxia , Larock Richard C.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Diarylamines in the Thiophene Series by Buchwald—Hartwig Coupling.
Authors: Begouin Agathe , Hesse Stephanie , Queiroz Maria‐Joao R. P. , Kirsch Gilbert
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
A Strategy to Avoid Anomalous O‐Alkylation of 4‐Hydroxyindole by Diethyl Bromomalonate.
Authors: Papageorgiou George , Corrie John E. T.
Published: January 2006

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Synthesis and Tuberculostatic Activity of Some 1,1‐Bis‐methylthio‐2‐nitro‐ethene Derivatives.
Authors: Foks Henryk , Pancechowska‐Ksepko Danuta , Janowiec Mieczyslaw , Zwolska Zofia , Augustynowicz‐Kopec Ewa
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Pyrrolo[2,1‐b]thiazol‐3‐one Derivatives.
Authors: Tverdokhlebov Anton V. , Andrushko Alexander P. , Tolmachev Andrey A. , Kostyuk Alexander N. , Chernega Alexander N. , Rusanov Eduard B.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Samarium Barbier Reactions of α‐Iodomethyloxazoles and Thiazoles with Aliphatic Aldehydes.
Authors: Williams David R. , Berliner Martin A. , Stroup Bryan W. , Nag Partha P. , Clark Michael P.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
9,12‐Dibenzothiazolylhypericin and 10,11‐Dibenzothiazolyl‐10,11‐didemethylhypericin: Photochemical Properties of Hypericin Derivatives Depending on the Substitution Site.
Authors: Waser Mario , Popova Yulita , Klampfl Christian W. , Falk Heinz
Published: January 2006

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Synthesis and Antimycobacterial Activity of Alkyl 1‐Heteroaryl‐1H‐1,2,3‐triazole‐4‐carboxylates.
Authors: Japelj Bostjan , Recnik Simon , Cebasek Petra , Stanovnik Branko , Svete Jurij
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Solvent‐Free Synthesis of 2‐Pyrones from Alkynes and Carbon Dioxide Catalyzed by Ni(1,5‐cyclooctadiene)2/Trialkylphosphine Catalysts.
Authors: Kishimoto Yasuhisa , Mitani Ikuko
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Rhodium‐Catalyzed Tandem Cyclization—Cycloaddition Reactions of Enynebenzaldehydes: Construction of Polycyclic Ring Systems.
Authors: Shin Seunghoon , Gupta Arun Kumar , Rhim Chul Yun , Oh Chang Ho
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
One‐Pot Synthesis of 3‐Aryl‐3H,4H‐[1,2]‐dithiolo[3,4‐b]benzothiopyran‐4‐ones and 1‐(o‐Bromophenyl)‐3‐aryl‐2‐prop‐2‐en‐1‐ones.
Authors: Mukherjee Chandrani , Zhang Hongming , Biehl Edward R.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of 2‐Cyanoacrylates Containing Pyridinyl Moiety under Ultrasound Irradiation.
Authors: Zhang Huiping , Song Baoan , Zhong Huimin , Yang Song , Jin Linhong , Hu Deyu , He Wei
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Preparation and Properties of Antitubercular 1‐Piperidino‐3‐arylthioureas.
Authors: Hearn Michael J. , Webster Eleanor R. , Cynamon Michael H.
Published: January 2006

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The Discovery of Fluoropyridine‐Based Inhibitors of the Factor VIIa/TF Complex.
Authors: Kohrt Jeffrey T. , et al. et al.
Published: January 2006

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One‐Pot Synthesis and Aromatization of 1,4‐Dihydropyridines in Refluxing Water.
Authors: Xia Jing‐Jing , Wang Guan‐Wu
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
A Facile Synthesis of New 2‐Carboxamido‐3‐carboxythiophene and 4,5,6,7‐Tetrahydro‐2‐carboxamido‐3‐carboxythieno[2,3‐c]pyridine Derivatives as Potential Endothelin Receptors Ligands.
Authors: Pittala Valeria , Modica Maria , Romeo Giuseppe , Materia Luisa , Salerno Loredana , Siracusa Mariangela , Cagnotto Alfredo , Mereghetti Ilario , Russo Filippo
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
A Facile Synthesis of Substituted Pyridines and Pyrazolo[3,4‐b]pyridines.
Authors: Kidwai M. , Thakur R. , Saxena S.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Some Pyrazolo[3,4‐d]pyrimidine Derivatives for Biological Evaluation.
Authors: Shamroukh A. H. , Rashad A. E. , Sayed H. H.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Substituted Tetraazaacenaphthylenes as Potent CRF1 Receptor Antagonists for the Treatment of Depression and Anxiety.
Authors: St‐Denis Y. , et al. et al.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of 5‐Substituted Uracils and 2,4‐Dimethoxypyrimidines by Wittig Olefination.
Authors: Coutouli‐Argyropoulou Evdoxia , Zachariadou Christina
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Trifluoroethylamines as Amide Isosteres in Inhibitors of Cathepsin K.
Authors: Black W. Cameron , et al. et al.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Some New 3‐Alkylthio Derivatives of 1‐Phenyl‐1H‐[1,3,4]thiadiazino[5,6‐b]quinoxalines
Authors: Bakavoli M. , Nikpour M. , Rahimizadeh M.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Properties of New Macrocyclic Compounds. Utilization of Bond Character of Hypervalent Sulfur in Tetraazathiapentalene Derivatives.
Authors: Matsumura Noboru , Hirase Ryuji , Kamitani Shigeki , Okumura Yasuyuki , Mizuno Kazuhiko
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Radical Cyclizations of Alkenyl Acylphosphonate Derivatives under Thermal and Photochemical Conditions.
Authors: Cho Chang Ho , Kim Sunggak , Yamane Motoki , Miyauchi Hironori , Narasaka Koichi
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
A Superior Method for the Reduction of Secondary Phosphine Oxides.
Authors: Busacca Carl A. , et al. et al.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis, Antimicrobial Activity, and 77Se NMR of Some New Pyrrole Derivatives Containing a Diphenyl Selenide Moiety.
Authors: Abdel‐Hafez Sh. H. , Anthonsen H. W. , Sliwka H.‐R. , Partali V.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
The First Synthesis and Reaction of β‐Ethoxy‐α‐fluoro‐α‐(phenylselanyl)ethene: Scandium or Lanthanum Triflate Catalyzed α‐Fluoroformylalkenylation of Aldehydes.
Authors: Hatanaka Fuminori , Tsuchiya Miyuki , Yoshimatsu Mitsuhiro
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Rapid Access to the Welwitindolinone Alkaloid Skeleton by Cyclization of Indolecarboxaldehyde Substituted Cyclohexanones.
Authors: Baudoux Jerome , Blake Alexander J. , Simpkins Nigel S.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Caldaphnidines A—F, Six New Daphniphyllum Alkaloids from Daphniphyllum calycinum
Authors: Zhan Zha‐Jun , Zhang Chuan‐Rui , Yue Jian‐Min
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis and anti‐HIV Activity of Novel Phenyl Branched Cyclopropyl Nucleosides.
Authors: Wu Ying , Hong Joon Hee
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Bicyclic Nucleoside Inhibitors of Varicella—Zoster Virus: The Effect of Branching in the p‐Alkylphenyl Side Chain.
Authors: Luoni Giovanna , McGuigan Christopher , Andrei Graciela , Snoeck Robert , De Clercq Erik , Balzarini Jan
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Convenient Synthesis of Volatile Streptomyces Lactones.
Authors: Amonkar Chandan P. , Tilve Santosh G. , Parameswaran P. S.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of (‐)‐Amphidinolide K Fragment C9—C22.
Authors: Andreou Thanos , Costa Anna M. , Esteban Laia , Gonzalez Lluisa , Mas Gemma , Vilarrasa Jaume
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis and in vitro Pharmacological Studies of New C(2) Modified Salvinorin A Analogues.
Authors: Cohen Bruce , et al. et al.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Novel Curcumin Mimics with Asymmetrical Units and Their Anti‐angiogenic Activity.
Authors: Woo Ho Bum , Shin Woon‐Seob , Lee Seokjoon , Ahn Chan Mug
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Spintronics and Ferromagnetism in Wide‐Band‐Gap Semiconductors
Authors: Dietl Tomasz
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Shape‐Controlled Synthesis of Metal Nanostructures: The Case of Silver
Authors: Wiley Benjamin , Sun Yugang , Mayers Brian , Xia Younan
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Bis(pyrrolide‐imine) Ti Complexes with MAO: A New Family of High Performance Catalysts for Olefin Polymerization
Authors: Yoshida Yasunori , Matsui Shigekazu , Fujita Terunori
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Fluorinated Bis(phenoxy—imine) Ti Complexes with MAO: Remarkable Catalysts for Living Ethylene and Syndioselective Living Propylene Polymerization
Authors: Furuyama Rieko , Saito Junji , Ishii Seiichi , Makio Haruyuki , Mitani Makoto , Tanaka Hidetsugu , Fujita Terunori
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Carbohydrate Scaffolds for the Production of Bioactive Compounds
Authors: Cipolla L. , Peri F. , La Ferla B. , Redaelli C. , Nicotra F.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Metallocene‐Catalyzed Selective Reactions
Authors: Kotora Martin
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Diastereomers Do, What They Should Not Do
Authors: Brunner Henri
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
New Synthetic Methods for 2‐Pyridone Rings
Authors: Torres Mercedes , Gil Salvador , Parra Margarita
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Cycloadditions, Cycloisomerizations and Related Reactions of Alkynes Bearing Group 13 or 14 Heteroelements
Authors: Gandon Vincent , Aubert Corinne , Malacria Max
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Introduction to Fluorous Catalysis
Authors: Horvath Istvan T.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
New Chemical Tools for Protein Modification
Authors: Francis Matthew B. , Antos John M. , Bains Sukhmine , Crochet Amanda P. , Gilmore Joshua M. , Hooker Jacob M. , Joshi Neel S. , McFarland Jesse M. , Nguyen Trung , Patel Amish A. , et al. et al.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
α‐Amino Acids, β‐Amino Alcohols and Related Compounds as Chiral Auxiliaries, Ligands and Catalysts in the Asymmetric Aldol Reaction
Authors: Vicario Jose L. , Badia Dolores , Carrillo Luisa , Reyes Efraim , Etxebarria Juan
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Bile Acid Derivatives as Enantiodifferentiating Host Molecules in Inclusion Processes
Authors: Bortolini Olga , Fantin Giancarlo , Fogagnolo Marco
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Phosphonium Salts as Room‐Temperature Ionic Liquids in Organic Synthesis
Authors: McNulty James , Capretta Alfredo , Cheekoori Sreedhar , Clyburne Jason A. C. , Robertson Al J.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
α‐Lactams
Authors: Hoffman R. V. , Cesare V.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
The Impact of Bacterial Genomics on Natural Product Research
Authors: Bode Helge B. , Mueller Rolf
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Clinical Features of Molecular Pathology of Solid Tumors in Childhood
Authors: Messahel Boo , Hing Sandra , Nash Ruth , Jeffrey Iona , Pritchard‐Jones Kathy
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
All‐Metal Aromaticity and Antiaromaticity
Authors: Boldyrev Alexander I. , Wang Lai‐Sheng
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis, Crystal Structure, and Magnetic Properties of the Semihard Itinerant Ferromagnet RhFe3N.
Authors: Houben Andreas , Mueller Paul , von Appen Joerg , Lueken Heiko , Niewa Rainer , Dronskowski Richard
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
High Energy Density Materials from Azido Cyclophosphazenes.
Authors: Muralidharan K. , Omotowa Bamidele A. , Twamley Brendan , Piekarski Crystal , Shreeve Jean'ne M.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Systematic Study on Structural Phase Behavior of CdSe Thin Films.
Authors: Kale R. B. , Lokhande C. D.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Electon‐Precise/Deficient La5‐xCaxGe4 (3.4 ≤ x ≤ 3.8) and Ce5‐xCaxGe4 (3.0 ≤ x ≤ 3.3): Probing Low‐Valence Electron Concentrations in Metal‐Rich Gd5Si4‐Type Germanides.
Authors: Wu Li‐Ming , Kim Sang‐Hwan , Seo Dong‐Kyun
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Patterned Fluorescence Images Using a Photocleavable NVOC‐Protected Quinizarin.
Authors: Min Sung‐Jun , Ahn Kwang‐Duk , Kim Jong‐Man
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Chiral (Iminophosphoranyl)ferrocenes: A New Class of Practical Ligands for Rhodium‐Catalyzed Asymmetric Hydrogenation.
Authors: Co Thanh Thien , Shim Sang Chul , Cho Chan Sik , Kim Tae‐Jeong , Kang Sang Ook , Han Won‐Sik , Ko Jaejung , Kim Chung‐Kyun
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
An Efficient and Practical Chemoenzymatic Preparation of Optically Active Secondary Amines.
Authors: Hu Shanghui , Tat David , Martinez Carlos A. , Yazbeck Daniel R. , Tao Junhua
Published: January 2006

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Aluminum Triflate: A Remarkable Lewis Acid Catalyst for the Ring Opening of Epoxides by Alcohols.
Authors: Bradley D. , Williams G. , Lawton Michelle
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Highly Enantio‐ and Diastereoselective Tandem Generation of Cyclopropyl Alcohols with up to Four Contiguous Stereocenters.
Authors: Kim Hun Young , Lurain Alice E. , Garcia‐Garcia Patricia , Carrol Patrick J. , Walsh Patrick J.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Bromination of Isomeric 7,8‐Dibromobenzobicyclo[2.2.2]octa‐2,5‐dienes: Neighboring Group Effect on Bromination.
Authors: Dastan Arif
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of OLED Materials of Several Triarylamines by Palladium Catalysts and Their Light Emitting Property.
Authors: Yu Mingxin , Wang Meijun , Chen Xiaohang , Hong Bingbing , Zhang Xiaoyan , Cheng Chienhong
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Lewis Acid—Lewis Acid Heterobimetallic Cooperative Catalysis: Mechanistic Studies and Application in Enantioselective Aza‐Michael Reaction.
Authors: Yamagiwa Noriyuki , Qin Hongbo , Matsunaga Shigeki , Shibasaki Masakatsu
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
General Catalysts for the Suzuki—Miyaura and Sonogashira Coupling Reactions of Aryl Chlorides and for the Coupling of Challenging Substrate Combinations in Water.
Authors: Anderson Kevin W. , Buchwald Stephen L.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Reactivity of Grubbs′ Catalysts with Urea‐ and Amide‐Substituted Olefins. Metathesis and Isomerization.
Authors: Formentin Pilar , Gimeno Nelida , Steinke Joachim H. G. , Vilar Ramon
Published: January 2006

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3‐Nitro‐2‐naphthalenemethanol: A Photocleavable Protecting Group for Carboxylic Acids.
Authors: Singh Anil K. , Khade Prashant K.
Published: January 2006

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Iron(III) Fluoride: A Highly Efficient and Versatile Catalyst for the Protection of Carbonyl Compounds under Solvent‐Free Conditions.
Authors: Bandgar Babasaheb P. , Kamble Vinod T. , Kulkarni Ashwini
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
An Improved Protocol for the Selective Hydroaminomethylation of Arylethylenes.
Authors: Routaboul Lucie , Buch Cathleen , Klein Holger , Jackstell Ralf , Beller Matthias
Published: January 2006

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Antibody‐Catalyzed Asymmetric Intramolecular Michael Addition of Aldehydes and Ketones to Yield the Disfavored cis‐Product.
Authors: Weinstain Roy , Lerner Richard A. , Barbas Carlos F. III , Shabat Doron
Published: January 2006

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Synthesis of 4‐(1,2,2‐Tricyanovinyl)‐2,6‐di‐tert‐butylphenol and the Corresponding Phenoxyl Radical.
Authors: Gorbunov A. I. , Davydova O. A. , Shpakov A. V. , Klimov. E. S. Klimov. E. S.
Published: January 2006

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Alkene Synthesis: Elimination of Arenesulfinic Acid from Alkyl Aryl Sulfones Using Potassium Trimethylsilanolate as Base.
Authors: Baker‐Glenn Charles A. G. , Barrett Anthony G. M. , Gray Andrew A. , Procopiou Panayiotis A. , Ruston Mark
Published: January 2006

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One‐Pot Synthesis of N‐Methoxyindolinones, N‐Methoxymaleimides and Maleic Anhydrides from α‐Halogenated Hydroxamic Acids.
Authors: Boukhris Said , Souizi Abdelaziz
Published: January 2006

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Ligand‐Accelerated Vanadium‐Catalyzed Epoxidation in Water.
Authors: Bourhani Zainaba , Malkov Andrei V.
Published: January 2006

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Intramolecular Reactions of Hydroperoxides and Oxetanes: Stereoselective Synthesis of 1,2‐Dioxolanes and 1,2‐Dioxanes.
Authors: Dai Peng , Dussault Patrick H.
Published: January 2006

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One‐Pot Copper(I)‐Catalyzed Synthesis of 3,5‐Disubstituted Isoxazoles.
Authors: Hansen Trond V. , Wu Peng , Fokin Valery V.
Published: January 2006

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Pseudosaccharin Amine Derivatives: Synthesis and Elastase Inhibitory Activity.
Authors: Rode H. B. , Sprang T. , Besch A. , Loose J. , Otto H.‐H.
Published: January 2006

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Reaction of Ethyl 3‐Nitroacrylate with Phenyl Azide.
Authors: Makarova N. G. , Anisimova N. A. , Berkova G. A. , Deiko L. I. , Berestovitskaya V. M.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
The Allylic Azide Rearrangement: Achieving Selectivity.
Authors: Feldman Alina K. , Colasson Benoit , Sharpless K. Barry , Fokin Valery V.
Published: January 2006

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Unexpected Isolation of 4‐Isothiocyanatomethylene‐4H‐pyridine‐1‐carboxylic Acid Ethyl Ester as Potential Template in Organic Synthesis.
Authors: Sarhan Aladdin E. , Joergensen Per T. , Pedersen Erik B.
Published: January 2006

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A New Route to Acridines: Pauson—Khand Reaction on Quinoline‐Bearing 1‐En‐7‐ynes Leading to Novel Tetrahydrocyclopenta[c]acridine‐2,5‐diones.
Authors: Patin Amaury , Belmont Philippe
Published: January 2006

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The Catalytic Mannich Reaction of 1,1‐Difluoro‐2‐trialkyl(aryl)silyl‐2‐trimethylsilyloxyethenes: Preparation of β‐Amino Acid Derivatives.
Authors: Chung Woo Jin , Omote Masaaki , Welch John T.
Published: January 2006

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Chemistry of Phosphorus Ylides. Part 21. New Route for the Synthesis of Azetidinones. Reaction of Phosphonium Ylides with Benzil‐, o‐Naphthoquinone‐, and Triketonemonoanils.
Authors: Soliman Fouad M. , Said Medhat M. , Maigali Soher S.
Published: January 2006

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Synthesis of 1,3‐Diarylbenzo[c]selenophenes.
Authors: Mohanakrishnan Arasambattu K. , Amaladass P.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis of 5‐Hydroxy‐1,3‐benzoxathiol‐2‐one and 2‐Amino‐1,3‐benzothiazol‐6‐ol Derivatives from Chrysenequinonecarboxylic Acid.
Authors: Tret'yakova E. V. , Flekhter O. B. , Galin F. Z. , Shul'ts E. E. , Tolstikov G. A.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Glycosylation with Trichloroacetimidates in Ionic Liquids: Influence of the Reaction Medium on the Stereochemical Outcome.
Authors: Rencurosi Anna , Lay Luigi , Russo Giovanni , Caneva Enrico , Poletti Laura
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
A Ligand‐Free Solid‐Supported System for Sonogashira Couplings: Applications in Nucleoside Chemistry.
Authors: Garg Neil K. , Woodroofe Carolyn C. , Lacenere Christopher J. , Quake Stephen R. , Stoltz Brian M.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Dynamic Kinetic Resolution of α,β‐Unsaturated Lactones Through Asymmetric Copper‐Catalyzed Conjugate Reduction: Application to the Total Synthesis of Eupomatilone‐3.
Authors: Rainka Matthew P. , Milne Jacqueline E. , Buchwald Stephen L.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
An Efficient Synthesis of Carlosic Acid and Other 5‐Carboxymethyltetronates from Malates.
Authors: Schobert Rainer , Jagusch Carsten
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Synthesis to Determine the Absolute Configuration of (‐)‐Pyricuol, a Phytotoxin Isolated from Rice Blast Disease Fungus Magnaporthe grisea.
Authors: Nakamura Yoko , Kiyota Hiromasa , Ueda Rumi , Kuwahara Shigefumi
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
4‐Fluorosulfonylpiperidines: Selective 5‐HT2A Ligands for the Treatment of Insomnia.
Authors: Humphries Alexander C. , et al. et al.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Parallel Synthesis and Biological Evaluation of 5,6,7,8‐Tetrahydrobenzothieno[2,3‐d]pyrimidin‐4(3H)‐one Cytotoxic Agents Selective for p21‐Deficient Cells.
Authors: Jennings Lee D. , Kincaid Scott L. , Wang Yanong D. , Krishnamurthy Girija , Beyer Carl F. , McGinnis John P. , Miranda Miriam , Discafani Carolyn M. , Rabindran Sridhar K.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
The Chemistry of Gold‐Fluoro Compounds: A Continuing Challenge for Gold Chemists
Authors: Mohr Fabian
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
129Xe NMR Spectroscopy and 129Xe Chemical Shift Tensor as a Probe to Examine Physico‐Chemical Properties of Nanospace
Authors: Ueda Takahiro , Nakayama Hirokazu , Eguchi Taro
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Nanotube Spintronics: Magnetic Systems Based on Carbon Nanotubes
Authors: Schneider Claus M. , Kozhuharova R. , Groudeva‐Zotova S. , Zhao B. , Muehl T. , Moench I. , Vinzelberg H. , Ritschel M. , Leonhardt A. , Fink J.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
A Challenge for Chemistry: Very Large Inorganic Molecules Penetrate the Mesoscopic Realm
Authors: Patrut Adrian , Nicoara Adrian , Margineanu Dragos
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Magnetochemistry of Boron Hydride Structures. Empirical Aspects
Authors: Volkov V. V. , Ikorskii V. N.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Fifteen Years of Dancing with Vanadium
Authors: Crans Debbie C.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Combinatorial Chemistry in the Age of Chemical Genomics
Authors: Joseph Reni , Arya Prabhat
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Cycloaddition Reactions of Arynes
Authors: Guitian Enrique , Perez Dolores , Pena Diego
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Arylation Reactions via C—H Bond Cleavage
Authors: Miura Masahiro , Satoh Tetsuya
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Metal Amides and Imides
Authors: Bailey T. R.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
α,β‐Unsaturated Amides: Alk‐2‐ynamides, Arenecarboxamides, and Alk‐2‐enamides
Authors: Lipton M. F. , Mauragis M. A.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Development of New Methodologies for Entry to Targets of Therapeutic Interest
Authors: Osborn Helen M. I.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Polarized Absorption Properties of Oligothiophene Single Crystals and Thin Films
Authors: Borghesi A. , Sassella A. , Spearman P. , Tavazzi S.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Mutual Effect of Functional Groups and the Radical Center on the Reactivity of Nitroxyl Radicals
Authors: Malievskii A. D. , Shapiro A. B.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Organic Chemistry with the Short‐Lived Positron Emitters 11C and 18F
Authors: Wuest Frank R.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Cultivation, Biochemical, Molecular Biological and Medical Aspects of the Culinary—Medicinal Straw Mushroom Volvariella volvacea (Bull.:fr.) Singer (Agaricomycetideae)
Authors: Buswell John A. , Chen Mingjie
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Recent Advances of Mechanistic Studies on Asymmetric Hydrogenation of Dehydroamino Acid Derivatives Catalyzed by Diphosphine—Rh and —Ru Complexes
Authors: Tsukamoto Masaki , Kitamura Masato
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Studies on the Nonbonded Interactions of Divalent Organic Selenium
Authors: Iwaoka Michio , Tomoda Shuji
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
The Bruker ELEXSYS E600/680 W‐Band Spectrometer Series
Authors: Hoefer P. , Kamlowski A. , Maresch G. G. , Schmalbein D. , Weber R. T.
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Distant Echoes of the Accordion: Reduced Dimensionality, GFT‐NMR, and Projection—Reconstruction of Multidimensional Spectra
Authors: Freeman Ray , Kupce Eriks
Published: January 2006

For Abstract see ChemInform Abstract in Full Text.
Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas
Authors: Rades Dirk , Schild Steven E.
Published: January 2006

BACKGROUND

Two groups of central neurocytomas have been identified: typical and atypical neurocytomas. The more benign typical neurocytomas have a better prognosis. Complete resection of typical neurocytomas results in significantly better outcome than incomplete resection. The current study investigated whether the outcome after incomplete resection can be improved by postoperative stereotactic radiosurgery (SRS) or by conventional radiotherapy.

METHODS

The data of all neurocytoma patients reported since 1997, when the first neurocytoma patient treated with SRS was described, were reviewed. Patients who underwent complete resection or those with atypical neurocytoma were excluded from the analysis. Three different therapies were compared for overall survival (OS) and local control (LC): incomplete resection alone (ITR), ITR followed by conventional radiotherapy (ITR+cRT), and ITR followed by stereotactic radiosurgery (ITR+SRS).

RESULTS

Data were complete in 121 patients (59 ITR, 41 ITR+cRT, and 21 ITR+SRS). The 5‐year‐LC after ITR was 51%. LC was significantly better after ITR+cRT (87%, P = 0.001) and after ITR+SRS (100%, P = 0.004). The difference between ITR+cRT and ITR+SRS was not significant (P = 0.45). The 5‐year‐OS was 93% after ITR, 100% after ITR+cRT, and 100% after ITR+SRS. The differences between the various groups were not significant. The P‐values were 0.13 for ITR versus ITR+cRT, 0.29 for ITR versus ITR+SRS, and 1.0 for ITR+cRT versus ITR+SRS.

CONCLUSIONS

After ITR of typical neurocytomas, LC is significantly improved by both conventional radiotherapy and SRS. The results of both radiation treatments were similar. SRS is a reasonable alternative to conventional radiotherapy in selected patients. Cancer 2006. © 2006 American Cancer Society.
Problems with the current diagnostic approach to complex atypical endometrial hyperplasia
Authors: Soslow Robert A.
Published: January 2006

Endometrial carcinoma is the most common form of genital malignancy diagnosed in women. Simple hyperplasia without atypia lies closest to normal proliferative endometrium. On the other end of the spectrum of preinvasive neoplasms is complex atypical hyperplasia (CAH), which from biologic, morphologic, and clinical perspectives resembles well differentiated endometrioid adenocarcinoma (WDA). Because CAH and WDA share so many important characteristics, tests for any one or a combination of these cannot definitively separate the two entities. Morphologically, CAH resembles WDA and, in many cases, substantial diagnostic sophistication is required to distinguish between them using current criteria. Two noteworthy articles based on the findings of the Gynecologic Oncology Group Protocol 167 have been published in this edition of Cancer and provide a glimpse of one group's approach to the diagnosis of CAH and its relevance.

See also pages 804–11 and 812–9.
Fatigue in long‐term breast carcinoma survivors
Authors: Bower Julienne E. , Ganz Patricia A. , Desmond Katherine A. , Bernaards Coen , Rowland Julia H. , Meyerowitz Beth E. , Belin Thomas R.
Published: January 2006

BACKGROUND

A longitudinal study was designed to evaluate the prevalence, persistence, and predictors of posttreatment fatigue in breast carcinoma survivors.

METHODS

A sample of 763 breast carcinoma survivors completed questionnaires at 1–5 and 5–10 years after diagnosis, including the RAND 36‐item Health Survey, Center for Epidemiological Studies – Depression scale (CES‐D), Breast Cancer Prevention Trial Symptom Checklist, and demographic and treatment‐related measures.

RESULTS

Approximately 34% of study participants reported significant fatigue at 5–10 years after diagnosis, which is consistent with prevalence estimates obtained at 1–5 years after diagnosis. Approximately 21% reported fatigue at both assessment points, indicating a more persistent symptom profile. Longitudinal predictors of fatigue included depression, cardiovascular problems, and type of treatment received. Women treated with either radiation or chemotherapy alone showed a small improvement in fatigue compared with those treated with both radiation and chemotherapy.

CONCLUSIONS

Fatigue continues to be a problem for breast carcinoma survivors many years after cancer diagnosis, with 21% reporting persistent problems with fatigue. Several factors that may contribute to long‐term fatigue are amenable to intervention, including depression and comorbid medical conditions. Cancer 2006. © 2006 American Cancer Society.
Nonstationary electroosmotic flow in open cylindrical capillaries
Authors: Mishchuk Nataliya A. , González‐Caballero Fernando
Published: January 2006

A theoretical model of the EOF established in a wide capillary after the application of a stepwise voltage has been developed. Both periodical and aperiodical flow regimes were studied with arbitrary pulse/pulse or pulse/pause durations and amplitudes. The numerical analysis performed for a few types of periodical regimes showed the peculiarities of the profiles of liquid velocity and its displacement both for the transition to the stationary regime and for the quasi‐stationary periodical and aperiodical regimes.
Surface treatment and characterization: Perspectives to electrophoresis and lab‐on‐chips
Authors: Pallandre Antoine , de Lambert Bertrand , Attia Rafaële , Jonas Alain M. , Viovy Jean‐Louis
Published: January 2006

The control and modification of surface state is a major challenge in bioanalytical sciences, and in particular in electrokinetic separation methods, due to the importance of electroosmosis. This topic has gained recently a renewed interest, associated with the development of “lab‐on‐chips” systems that extend the range of materials in which separation channels are fabricated. The surface science community has developed through the years a large toolbox of characterization tools and surface modification protocols, which is not yet fully exploited in the bioanalytical world. In this paper, we try and present an overview of these tools, in order to stimulate new ideas for improved and more controlled surface treatment strategies for separations in capillaries and microchannels. We briefly describe some physical and chemical aspects of electroosmosis (global and spatially resolved), streaming current, and streaming potential. We also review the main strategies for surface coating, and compare the advantages of physisorption, well‐organized thin self‐assembled monolayers, or conversely thick polymer “brushes”. Examples of existing applications to electrophoresis in microchannel are also given.
Timing rearrangements of SEC and SASE slave clock chains due to non‐small input phase and frequency hits in synchronisation networks
Authors: Bregni Stefano
Published: January 2006

In the standard architecture of synchronisation network, chains of slave clocks (namely, stand‐alone synchronisation equipment, SASE, and SDH equipment clock, SEC) transfer timing along synchronisation trails. Hence, the need to assess precisely the performance of timing transfer along such chains, not only in stationary conditions, but also under transient rearrangements occurring after input phase and frequency hits, due for example to reference switching. If possible, system analysis should be carried out beyond the usual assumption of linear behaviour, which is rather restrictive holding only for small perturbations on the input.

In literature, very few papers analysed chains of slave clocks. In this work, the non‐linear transient behaviour of SEC and SASE clock chains has been simulated in the time domain, in order to evaluate their timing rearrangements after non‐small phase and frequency hits on the reference signal. Both homogeneous and non‐homogeneous chains of SEC and SASE clocks have been studied in various configurations, assuming the classic analogue PLL scheme, in order to provide a useful and comprehensive survey, both in qualitative and quantitative terms, on the timing performance achievable when planning synchronisation trails of various type and length in a synchronisation network. Copyright © 2006 AEIT
Efficient method to generate single‐copy transgenic mice by site‐specific integration in embryonic stem cells
Authors: Beard Caroline , Hochedlinger Konrad , Plath Kathrin , Wutz Anton , Jaenisch Rudolf
Published: January 2006

Transgenic and gene‐targeted mutant mice provide powerful tools for analysis of the cellular processes involved in early development and in the pathogenesis of many diseases. Here we describe a transgene integration strategy mediated by site‐specific recombination that allows establishment of multiple embryonic stem (ES) cell lines carrying tetracycline‐inducible genes targeted to a specific locus to assure predictable temporal and spatial expression in ES cells and mice. Using homologous recombination we inserted an frt homing site into which tetracycline‐inducible transgenes can be integrated efficiently in the presence of FLPe recombinase. This strategy and the vectors described here are generally applicable to any locus in ES cells and should allow for the rapid production of mice with transgenes efficiently targeted to a defined site. genesis 44:23–28, 2006. © 2006 Wiley‐Liss, Inc.
Utilization of mental health care services among older adults with depression
Authors: Crabb Rebecca , Hunsley John
Published: January 2006

Despite the availability of effective treatments for late life depression, data indicate that only a small minority of adults over the age of 65 years with depression access any kind of care for emotional or mental health problems. Using data from the Canadian Community Health Survey (Cycle 1.1), we compared patterns of mental health service utilization among middle‐aged (45–64 years), younger old (65–74 years), and older old (75 years and older) adults with and without depression and identified predictors associated with accessing different services (n = 59,302). Compared to middle‐aged adults with depression, individuals aged 65 and older with depression were less likely to report any mental health consultation in the past year and especially unlikely to report consulting with professionals other than a family physician. Age remained a significant predictor of mental health service utilization even after accounting for other relevant variables such as gender, marital status, years of education, depression caseness, and number of chronic medical conditions. Although the prevalence of depression is lower in older age groups, the present study provides compelling evidence that mental health services are particularly underutilized by depressed older adults. © 2005 Wiley Periodicals, Inc. J Clin Psychol 62: 299–312, 2006.
Oligodendrocyte differentiation is increased in transferrin transgenic mice
Authors: Sow Amina , Lamant Matthieu , Bonny Jean‐Marie , Larvaron Pierre , Piaud Oriane , Lécureuil Charlotte , Fontaine Isabelle , Saleh Maria‐Carla , Garcia Otin Angel Luis , Renou Jean‐Pierre , Baron Bruno , Zakin Mario , Guillou Florian
Published: January 2006

Transferrin (Tf), the iron transport glycoprotein found in biological fluids of vertebrates, is synthesized mainly by hepatocytes. Tf is also synthesized by oligodendrocytes (Ol), and several lines of evidence indicate that brain Tf could be involved in myelinogenesis. Because Tf is postnatally expressed in the brain, we sought to investigate whether Tf could intervene in Ol differentiation. For this purpose, we analyzed transgenic mice overexpressing the complete human Tf gene in Ol. We show that the hTf transgene was expressed only from 5 days postpartum onward. In the brain of 14‐day‐old transgenic mice, the DM‐20 mRNA level was decreased, whereas the PLP, MBP, CNP, and MAG mRNA levels were increased. We counted a higher proportion of Ol expressing the O4 (Ol‐specific antigens) and PLP in brain cells cultured from transgenic mice. These results support the idea that overexpressing Tf in the brain accelerates the oligodendrocyte lineage maturation. Accordingly, by NMR imaging acquisition of diffusion tensor in hTf transgenic mice, we observed early maturation of the cerebellum and spinal cord and more myelination in the corpus callosum. In addition, hTf overexpression led to an increase in Sox10 mRNA and protein. Increases in Sox10 and in Tf expression occur simultaneously during brain development. The Olig1 mRNA level also increased, but long after the rise of hTf and Sox10. The Olig2 mRNA level remained unchanged in the brain of transgenic mice. Our findings suggest that Tf could influence oligodendrocyte progenitor differentiation in the CNS. © 2006 Wiley‐Liss, Inc.
Human immunodeficiency virus type 1 gp120 inhibits long‐term potentiation via chemokine receptor CXCR4 in rat hippocampal slices
Authors: Dong Jun , Xiong Huangui
Published: January 2006

Human immunodeficiency virus type 1 (HIV‐1) infection in its human host often results in progressive dementia and encephalopathy in adults and children, respectively. The mechanisms underlying virus‐induced neurocognitive dysfunction are not fully understood. However, several studies strongly suggest that secretory viral and immune products from infected brain macrophages and microglia affect the onset and tempo of disease. One critical neurotoxin among these secretory products is the HIV‐1 envelope glycoprotein gp120. To better understand how HIV‐1 gp120 may affect cognitive function, we studied its effects on long‐term potentiation (LTP) in the CA1 region of rat hippocampus, the brain region best linked to learning and memory. Although no effects were observed on basal synaptic transmission, HIV‐1 gp120 inhibited LTP in a concentration‐dependent manner in the presence of γ‐aminobutyric acid type A (GABAA) receptor antagonist. Heat‐inactivated gp120 failed to block LTP. The HIV‐1 gp120‐mediated LTP inhibition was blocked by T140, a chemokine receptor CXCR4 antagonist, demonstrating gp120 inhibition of LTP via CXCR4. HIV‐1 gp120 V3 loop peptides mimicked the inhibitory effects of HIV‐1 gp120 protein on LTP. Monoclonal antibodies against the V3 loop epitope KRIHI eliminated the HIV‐1 gp120 effects on LTP. These results further underscore the importance of HIV‐1 gp120 in the pathogenesis of HIV‐1‐associated cognitive impairments seen during progressive viral infection. © 2006 Wiley‐Liss, Inc.