bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptation of Teacher Immunity Scale to Turkish: Validity and Reliability Study
Authors: POLAT Mustafa , ERDEM Cahit
Published: August 2023

The literature on teacher identity has yet to fully succeed to address the relationship between personal and contextual factors of teacher identity. Therefore, researchers are attempting to come up with constructs that better account for teacher identity. Accordingly, teacher immunity is a new concept that is a construct teachers develop either productively or maladaptively to protect themselves from the ever-increasing stress and challenges in instructional environments. This study aims to adapt the Language Teacher Immunity Questionnaire (Hiver, 2017) to Turkish culture. Research data were collected from a sample of teachers from various branches working in public and private schools (n=357). The scale adaptation process consists of 20 consecutive steps offered by the researchers based on a comprehensive literature review. When linguistic equivalency was ensured, confirmatory factor analysis was performed for construct validity, and internal consistency was tested through McDonald’s Omega coefficients. After some modifications, the fit indices were above acceptable levels. Also, convergent and divergent validity were examined. According to the results, the Teacher Immunity Scale (TIS) in a 6-point Likert-type format consisting of 32 items gathered under seven factors preserved the original factor structure. This study offers a valid and reliable Turkish adapted form of TIS that can be used with teachers from all branches. Teacher immunity is an emerging concept in teacher identity research, and this adapted instrument allows researchers to research the construct in Turkish.
Comparing Active Auditors viewpoints in Public and Private Sector over Determining Basic Materiality Levels in Auditing
Authors: Farajzadeh Ali Asghar , Azizzadeh Tahereh
Published: August 2023

Materiality is a threshold quality in accounting which has priority over other qualitative characteristics of financial information. In other word, financial information are important in decision-making only when they are important with respect to this to definition, omission or altering these significant information can change the judgments and decisions ofÂ  logical user over the affairs of a business entity. The purpose of this research was to identify the auditors` ideas in private and public sector over basic materiality levels and compare the perspective of these two groups over these levels. The statistical population of this research is managers in auditing firm, partners in auditing institutions. According to Kukran formula, the sample volumes of this research are 84 people. The results indicate that, there is a meaningful difference between high and low important levels from the viewpoint of active auditors in private and public sectors. This means that there is no consensus between these two groups in determining high materiality level. In other words, in determining the low important level, the average viewpoint of auditors in auditing organization in relation to private sector is minimum. We concluded that public sector's auditors are more conservative than the ones in private sector.
Approaches of technological integrator at selection of object parameters on concept design stage
Authors:   JSC «RZD», Abdullaev Ildar Salimovich
Published: August 2023

The paper is devoted to selection of optimal parameters of railway infrastructure objects on the concept design stage. The author considers problems that arise at designing and applying normative documentation and lead to excess of the initial cost of objects, as well as tools that can be used for solving such problems by a technological integrator - independent division of the JSC «RZD». As an important aspect of the analysis of concept design documentation the paper presents possible approaches to determination of stage-by-stage development of railway infrastructure objects. Moreover, it provides specific examples and a complex of technological measures.
Methodological approaches to organization of transportation process on the basis of technical and technological parameters
Authors:   Russian University of Transport (RUT-MIIT), Borodin Andrey Fedorovich , Panin Vitaliy Vladimirovich ,   JSC «Institute of Economics and Development of Transport» (JSC «IEDT»), Maximova Evgeniya Sergeevna ,   Russian University of Transport (RUT-MIIT), Lakhankin Evgeniy Alexandrovich ,   JSC «Institute of Economics and Development of Transport» (JSC «IEDT»)
Published: August 2023

In conditions of growing loading of railways and shortage of investments management reserves based on assessment of technical and technological parameters of organization of transportation process with the consideration for resources of infrastructure, rolling stock, consignors, consignees and volumes of repairs and construction works become of paramount significance for provision of stable operation. The paper presents results of development of technical and technological parameters for operations control on enlarged network lines.
Verification of optimization model of car traffic processing at marshalling station by simulation modeling
Authors:   Ural state university of railway transport (USURT), Alexandrov Alexander Ernstovich , Kovalev Igor Alexandrovich ,   Ural state university of railway transport (USURT), Permikin Vadim Yuryevich ,   Ural state university of railway transport (USURT), Surin Alexander Vladimirovich ,   Ural state university of railway transport (USURT), Lesnykh Vladislav Vladislavovich Lesykh ,   Ural state university of railway transport (USURT)
Published: August 2023

As a rule, current planning of operation of marshalling station is carried out with the use of heuristic algorithms and simulation modeling. It is possible to improve the quality of planning on the basis of strict optimization models. With the use of the mixed integer linear programming method the authors have created a mathematical and a computer model of car traffic processing at a marshalling station. The paper considers questions of verification of the optimization model with the use of simulation modeling.
Study of operation of correlation receiver with quadrature continuously working automatic cab signalling channels in nominal conditions of operation
Authors:   Samara State Transport University (SSTU), Yusupov Ruslan Rifovich , Khokhrin Alexey Sergeevich ,   Samara State Transport University (SSTU)
Published: August 2023

Development and implementation of receivers of CWACS channels on a microelectronic elemental base with digital processing of signals allowed using complicated methods (for example, correlation, non-linear) that couldn’t be realized on an analogue elemental base. One of the devices, in which the similar methods are applied, is a correlation receiver with quadrature channels. The paper considers its operation in nominal conditions. The study was carried out by simulation modeling in the Simulink environment. An experiment on the model showed that the normative operation of the receiver in some cases is violated because of the imperfection of an algorithm for calculation of a floating threshold of decision making. Adjustment of the algorithm provided correct operation of the receiver in the considered conditions. Moreover, the authors have revealed that real sensitivity of the receiver match normative requirements.
Main directions of development of high-speed passenger transport in large and largest Russian cities
Authors:   Ural state university of railway transport (USURT), Nevolin Dmitriy Germanovich , Tsarikov Alexey Alexeevich ,   Ural state university of railway transport (USURT), Bondarenko Viktor Grigoryevich ,   Ural state university of railway transport (USURT)
Published: August 2023

The paper considers problems of development of high-speed types of urban passenger transport. The authors propose a differentiated approach to solution of these problems according to potential passenger traffic and financial possibilities of municipal units.
Development of approach to increase quality of repair of wheelset axles
Authors:   Kurgan Institute of Railway Transport (KIRT), Rogov Evgeniy Yuryevich , Ovsyannikov Viktor Evgenyevich ,   Kurgan State University (KSU), Vasilyev Valeriy Ivanovich ,   Kurgan State University (KSU), Lapshin Vasiliy Fedorovich ,   Ural state university of railway transport (USURT)
Published: August 2023

One of the main requirements, which is set to executive surfaces of wheelset axles, is an accuracy of a form in transverse direction (deviation from roundness). Since methods of final processing (centerless grinding and rolling) don’t correct inaccuracies of the form, for the provision of the required accuracy of the form turn machining operations are used, including operations on the numerically controlled machines. At the application of such machines it is necessary to reveal processes that have a major impact on processing inaccuracy and to develop an approach that will decrease the impact. The paper considers features of creating a texture of the transverse profile of rotation body parts at turning. With the use of the random processes theory and methods of fractal geometry the authors studied systematic and random components of the profile. On the basis of analysis of gained results the authors show that at finishing processing vibrations of elements of the processing system have a major impact. As a result, they have formulated an approach to automatic provision of required parameters of accuracy of the form of wheelset axles at processing with the use of numerically controlled machinery.
System for prevention from collisions at railway crossing at forced stop of motor transport
Authors:   Ural state university of railway transport (USURT), Popov Anton Nikolaevich
Published: August 2023

The paper suggests a realization of a system for prevention from collisions at a railway crossing at a forced stop of motor transport. The author considers an algorithm, features of realization and variants of application of existing equipment for the system creation. Moreover, the author describes a control device prototype that is necessary for creating the suggested system. As a result, the paper presents advantages of the proposed solutions in comparison with existing automatic level crossing safety installation systems.
Expansion of service in railway station complexes
Authors:   Ural state university of railway transport (USURT), Parshina Valentina S. , Gileva Olga V. ,   Ural state university of railway transport (USURT)
Published: August 2023

The article is devoted to the problem of expanding the list of services at railway stations. The foreign experience of station equipment is presented. In order to determine the list of services in the station complexes, a pilot survey of the population of different age groups and types of activities was conducted. The results of the survey allow us to conclude that it is advisable to conduct research in this direction to meet the multilateral needs of passengers and customers, improve the efficiency of functioning of railway stations, and develop the service sector.
Robotization of routine operations in the maintenance of information systems of JSC «Russian Railways»
Authors:   Ural state university of railway transport (USURT), Korobitsyn Pavel Yu. , Volynskaya Anna V. ,   Ural state university of railway transport (USURT)
Published: August 2023

The article illustrates the effectiveness of robotization of routine operations of the automated management system of unified user support service (AMS UUSS), designed to generate user requests for IT services from the external portal or self-service portal of the AMS UUSS by reducing the execution time of user requests.
Investigation of radio frequency characteristics of RFID indicators for linear polymer insulators of various voltage levels
Authors:   Ural state university of railway transport (USURT), Nesenyuk Tatiana A. , Sokolov Viktor N. ,   Ural state university of railway transport (USURT), Maksimova Inna N. ,   Ural state university of railway transport (USURT), Nikitina Evgenia P. ,   Ural state university of railway transport (USURT)
Published: August 2023

The article describes the possibilities of using the digital method of non-destructive testing of polymer linear insulators using RFID technologies. The possibility of installing RFID indicators is being considered not only on specially designed insulators with built-in electrodes, but also on standard insulators currently produced by Russian manufacturers. The location of RFID indicators for installation on polymer linear insulators of the LC type is shown. A comparison of the radiation patterns of RFID indicators installed on polymer insulators with the voltage of 110 and 35 kV is provided, the results obtained are analyzed. Conclusions are drawn about the possibility of using RFID-indication for insulators at different voltage levels for both overhead power lines and contact network insulators.
The infl uence of geometric parameters on the quality of coupling of a toothed traction gear of the 2ES6 freight electric locomotive
Authors:   Ural state university of railway transport (USURT), Buynosov Alexander P. , Sharapov Alexander T. ,   Ural state university of railway transport (USURT), Dolgikh Yegor A. ,   Ural state university of railway transport (USURT)
Published: August 2023

The article presents comparison of the quality of coupling the 2ES6 electric locomotive toothed traction gear when the tilt angle of the teeth on the dividing cylinder changes. Recommendations are given on the possible increase in the tilt angle of the teeth in order to increase the load capacity of the transmission. The influence of displacement coefficients on the quality of coupling is estimated. Models of gears of the 2ES6 freight electric locomotive were created. The comparison of the shape of the teeth for the original and optimized gears is shown.
Regarding the development of information systems in JSC «Russian Railways» (on the example of the East Siberian Railway)
Authors:   Irkutsk State Transport University (ISTU), Potekhina Anna M. , Potekhina Alexandra M. ,   Irkutsk State Transport University (ISTU)
Published: August 2023

The article discusses the alterations in the measures for throughput and carrying capacity, identified shortcomings in the information process. A brief overview of the software of AS EBL (Automated System Electronic Bill of Lading), AS TOM (Automated System of Transportation Operational Management), DM IL (Dynamic Model for Infrastructure Loading), AMS LP (Automated Management System of Local Performance), ETS URAL VNIIZHT (Executed Traffic Schedule URAL VNIIZHT) and other IT technologies of JSC “Russian Railways” used on the East Siberian Railway is provided. The conclusion is made about the advantages and disadvantages of the DM IL user interface.
Rare complication of skin necrosis after endoscopic debridement and cutaneo-fascial suture for a massive Morel-Lavallée lesion in Korea: a case report
Authors: Kim Youngmin , Cho Jayun , Jang Myung Jin , Choi Kang Kook
Published: August 2023

A Morel-Lavallée lesion (MLL) is a pathologic fluid collection within an abnormally formed space, resulting from an internal degloving injury between the muscle fascia and subcutaneous fat layer. Due to its resistance to conservative treatments such as drainage or compression dressing, various therapeutic methods have been developed for MLL. However, no standardized guidelines currently exist. Recently, endoscopic debridement and cutaneo-fascial suture (EDCS) has been introduced for the treatment of MLL, particularly for large lesions resistant to conservative approaches. While this procedure is known to be effective, limited reports are available on potential complications. The authors present a case of skin necrosis following EDCS for a massive MLL.
Wastewater monitoring of a community COVID-19 outbreak in a Spanish municipality
Authors: Barberá-Riera María , Llanos Rosa de , Barneo-Muñoz Manuela , Bijlsma Lubertus , Celma Alberto , Comas Iñaki , Gomila Bárbara , González-Candelas Fernando , Goterris-Cerisuelo Rafael , Martinez-Garcia Fernando , Santateresa Ernesto , Torres-Puente Manuela , Zamorano-López Núria , Bretón-Ramos Rafael , Aguilar-Perdiguer Eduardo , Rebagliato Marisa , Bellido-Blasco Juan , Hernández Félix
Published: August 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wastewater surveillance has become an increasingly important tool since the initial moments of the coronavirus disease (COVID-19) pandemic, mainly conducted at a large population scale. However, the large-sized sewersheds may not provide suitable information for monitoring localized outbreaks. After the declaration of a community COVID-19 outbreak in two neighborhoods of Castellón (Spain), SARS-CoV-2 RNA levels were monitored in wastewater samples. Moreover, genomic sequencing was performed. Thirty-three samples were collected in 2020, distributed over three points of the sewage network, two of which were close to the areas where the cases were declared. The third point was located at the inlet of the municipal wastewater treatment plant (WWTP). The samples were analyzed by RT-qPCR, using specific N1 and N2 target regions. The sum of confirmed cases, with the date of symptoms onset within the 3 weeks before each sampling day, was calculated. SARS-CoV-2 RNA was detected on most days in the two sampling points at neighborhood level, and the detection became negative when the number of cases with symptoms onset during the last 21 days in the study areas decreased to 0 or 1 case. The genomic sequencing performed for RNA from wastewater and clinical samples showed the same variant. The detection of SARS-CoV-2 and the subsequent non-detection provided the epidemiologists in charge of controlling the outbreak with useful information to confirm its closure, complementing the clinical and epidemiological data. Our findings illustrate the value of wastewater surveillance for localized outbreaks, especially in situations of low incidence of COVID-19 at the broader community level.
Zonificación de la capacidad protectora y vulnerabilidad a la contaminación del acuífero de Texcoco, Estado de México
Authors:   Posgrado IAUIA, Universidad Autónoma Chapingo. Carr. México - Texcoco, Km 38.5. Chapingo, Estado de México. C.P. 56230. México. (+52) 595 952 1551., Vázquez-Castro Ma. de Lourdes , Reyes-Gutiérrez Lázaro Raymundo ,   Universidad Autónoma Metropolitana Unidad Lerma. Av. De las Garzas No 10, Col. El Panteón, Lerma de Villada, Estado de México, C.P.52005 México. (+52) 728 282 7002., Carrillo-García Muricio ,   Posgrado IAUIA, Universidad Autónoma Chapingo. Carr. México - Texcoco, Km 38.5. Chapingo, Estado de México. C.P. 56230. México. (+52) 595 952 1551., Reyes-Ramírez Aurelio ,   Universidad Autónoma Chapingo. Carr. México - Texcoco, Km 38.5. Chapingo, Estado de México. C.P. 56230. México. (+52) 595 952 1551.
Published: August 2023

El estudio consistió en estimar la capacidad protectora y vulnerabilidad intrínseca natural del acuífero de Texcoco, mediante la combinación del método Índice de Vulnerabilidad del Acuífero (AVI, por su sigla en inglés) y el parámetro geoeléctrico de Dar Zarrouk (conductancia longitudinal unitaria, S). El acuífero de Texcoco, constituido por materiales lacustres, aluviales y depósitos volcánicos, se localiza al oriente del Valle de México. Se realizaron 87 sondeos eléctricos verticales Schlumberger (SEV) distribuidos en la zona del acuífero. Los datos de los SEV en campo se adquirieron con un resistivímetro Terrameter SAS-300B con abertura de electrodos de corriente de 750 m a ambos lados de un centro común y se interpretaron con el programa de computadora IX1D de Interpex. La conductancia longitudinal unitaria se obtuvo a partir de la inversión de los datos de campo y se elaboraron mapas de contornos con el método kriging y de mínima curvatura en Surfer V16. El espesor de la capa superior de la zona no saturada varía entre 0.3 y 10.5 m. La conductancia longitudinal de la capa superior presenta valores de 0.0 a 75 Siemens/m. El nivel del agua subterránea en el acuífero presenta una elevación de 2140 msnm en la zona centro sur y 2290 msnm en las estribaciones de la Sierra de Río Frío. Con el método AVI, a partir de los datos de la conductividad hidráulica, Kv (m/d) y el espesor h (m) de la zona no saturada, se obtuvieron valores de la resistencia hidráulica C = 1.4 a 3.9 días. Los resultados obtenidos son de interés para las autoridades municipales en la planeación y toma de decisiones.
Optimization of an Antifungal Nail Polish Containing Itraconazole 1% and Evaluation for Its Transungual Penetration
Authors: Nagfernandes Sukanya , Gupta Mali Ram
Published: August 2023

Broad-spectrum antifungal drug deployed for topical therapy, specific for onychomycosis, Itraconazole was used as the active pharmaceutical ingredient in a nail lacquer formulation1. The objective of the study was to optimize an antifungal nail lacquer, which when applied topically onto the dorsal surface of the nail plate would facilitate the transungual penetration of the drug. Itraconazole hydrochloride was synthesized to aid the formulation of the lacquers. The optimization involved comparing four different formulations of 1%w/w Itraconazole nail lacquers containing combinations of penetration enhancers (Papain, Salicylic acid, Urea) based on their ability to facilitate diffusion of the drug through the nail plate over five days. The drug uptake was quantified by extracting the drug from the nail clippings and analyzing it. The tests conducted to account for the quality of the optimized formulation were drug content, spread ability, check for precipitation, and accelerated stability. The results demonstrated that the optimized 1%w/w Itraconazole nail lacquer contained 5%w/w Papain, 5 %w/w Salicylic Acid, and 2.8% w/w Urea. The drug uptake from nail clippings was higher than the literature derived reference MIC90 value for T. Rubrum strain, and the quality of the optimized lacquer was not compromised throughout three weeks [2]. The hypothesis stated that the inclusion of Salicylic acid, Papain, and Urea in an Itraconazole (1%w/w) nail lacquer would have the highest transungual penetration on application to the nail plate. In conclusion, the hypothesis was accepted, and the optimized lacquer passed the drug uptake evaluation and all quality control tests.
Toxoplasmosis and Chlamydophilosis in Small Ruminant Farms in Cameroon: Knowledge, Attitudes, Practices and Perception of Zoonotic Risks of Farmers
Authors: CHIMI Roland NANKAM , KOUAMO Justin , Simo Kouam Michel Alain , FOTSAC Muller DZOUSSE , CHERMAPI DEMBENG Raphael , KOUENGOUA Armelle Prudence KOUENGOUA , SIMO Josué , NGOULA Ferdinand
Published: August 2023

Zoonotic abortive diseases represent a significant health and economic risk for national public health. This cross-sectional survey was conducted from April to October 2021 among 200 selected small ruminant farmers in the three northern regions of Cameroon. Data collection was done through questionnaires administered by exchange with the herder and responses were coded and recorded on an Excel spreadsheet. The data were then analyzed with R software, version 2.13.0. An ANOVA test was used to assess significant differences in mean of Knowledge, Attitudes, Practices and Perception of zoonotic risks (KAPP) scores between regions. Pearson correlations were used to calculate the association between KAPP scores within regions. Small ruminant farmers surveyed had low mean scores for knowledge of abortive Toxoplasmosis and Chla-mydophilosis (0.1 ± 0.2), desirable attitude (0.32 ± 0.07), appropriate practice (0.36 ± 0.13) in managing abortion, and positive perception of zoonotic risks of Toxoplasmosis and Chlamydo-philosis in small ruminants (0.12 ± 0.33), respectively. KAPP was significantly (p<0.01) and posi-tively associated with knowledge (r=0.98) and risk perception (r=0.99). However, attitudes (r=0.06), practices (r=0.05) and risk perception of toxoplasmosis (r=0.07) and Chlamydophilosis (r=0.08) were not associated with farmers' knowledge. This study revealed significant knowledge gaps, low levels of desired attitudes, and high-risk behavioral practices. These results therefore call for capacity building of health professionals and farmers to better integrate the One Health concept in the management of neglected zoonotic diseases.
Revision of the Genus Sycanus Amyot & Serville, 1843 (Heteroptera: Reduviidae: Harpactorinae) from China Based on DNA Barcoding and Morphological Evidence
Authors: Zhao Ping , Chen Suyi , Wang Jianyun , Chen Zhuo , Li Hu , Cai Wanzhi
Published: August 2023

Due to the variation of the body coloration and the similarity of the related species, there are still some unresolved problems and debates in the taxonomic study of the genus Sycanus in China. We conducted the inter-specific phylogenetic analyses and the species delimitation for Sycanus in China based on DNA barcoding dataset of the mitochondrial cytochrome c oxidase subunit I gene of 81 samples and partial 28S rDNA sequences of 31 samples. The result showed that all the samples were divided into twelve species by integrating the results of DNA barcoding and morphological comparison. In the present paper, the genus Sycanus in China was reviewed systematically, all species were described or re-described, keyed, illustrated and photographed, among them, Sycanus taiwanensis Zhao & Cai sp. nov., Sycanus hsiaoi Li & Cai sp. nov. and Sycanus hainanensis Wang & Cai sp. nov. were described as new to science. The biological informations of Sycanus falleni Stål, 1863 and Sycanus croceus Hsiao, 1979 were briefly recorded.
Integrated Smart Gas Tracking Device with Artificially Tailored Selectivity for Real-Time Monitoring Food Freshness
Authors: Xu Yuli , Liu Zicheng , Lin Jinren , Zhao Jintao , Hoa Nguyen Duc , Hieu Nguyen Van , Ganeev Alexander A. , Chuchina Victoria , Jouyban Abolghasem , Cui Daxiang , Wang Ying , Jin Han
Published: August 2023

Real-time monitoring the freshness of food that stored in refrigerator is of great significance to alarm the potential food spoilage and prevent severe health problems. Among those frequently reported methods, discriminating the food freshness through tracking volatile compounds receives extensive attention. Nevertheless, the ambient environment of low temperature (normally below 4oC) and high humidity (90% R.H.) as well as poor selectivity in sensing gas species still remain the challenge. In this research, an integrated smart gas tracking device is deigned and fabricated. Through applying pump voltage on an yttria-stabilized zirconia (YSZ) membrane, oxygen concentration in the testing chamber can be manually tailored. Due to working principle of the sensor follows the mixed potential behavior, distinct difference in sensitivity and selectivity are observed for the sensor that operated at different oxygen concentration. Typically, the sensor gives satisfactory selectivity to H2S, NH3, C2H5OH at the oxygen concentration of 10%, 30% and 40%, respectively. In addition, acceptable response/recovery rate (within 24 s) is also confirmed. Finally, a refrigerator prototype that includes the smart gas sensor is built, and satisfactory performance in discriminate food freshness status of fresh or semi-fresh is verified for the proposed refrigerator prototype. In conclusion, these aforementioned promising results suggest that the proposed integrated smart gas sensor could be a potential candidate for alarming food spoilage.
Foodomics-based Approaches Shed Light on the Potential Protective Effects of Polyphenols in Inflammatory Bowel Disease
Authors: Pratelli Giovanni , Tamburini Bartolo , Carlisi Daniela , De Blasio Anna , D'Anneo Antonella , Emanuele Sonia , Notaro Antonietta , Affranchi Federica , Giuliano Michela , Seidita Aurelio , Lauricella Marianna , Di Liberto Diana
Published: August 2023

Inflammatory Bowel Disease (IBD) is a chronic and progressive inflammatory disorder affecting the gastrointestinal tract (GT) caused by a wide range of genetic, microbial, and environmental factors. IBD is characterized by chronic inflammation, decreased gut microbial diversity and dysbiosis, with a lower amount of beneficial bacteria and a concomitant increase of pathogenic species. It is well known that dysbiosis is closely related to the induction of inflammation and oxidative stress, this last caused by an imbalance between reactive oxygen species (ROS) production and cellular antioxidant capacity that leads to cellular ROS accumulation. ROS are responsible for the intestinal epithelium oxidative damage and the increased intestinal permeability found in IBD patients and their reduction could represent a potential therapeutic strategy to limit the IBD progression and alleviate its symptom. Recent evidence highlighted that dietary polyphenols, natural antioxidants, are able to maintain redox equilibrium in the GT preventing gut dysbiosis, intestinal epithelium damage and radical inflammatory responses. Here, we suggest that the relatively new foodomics approaches, together with new technologies for promoting the antioxidative properties of dietary polyphenols, including novel delivery systems, chemical modifications and combination strategies, may provide critical insight to determine the clinical value of polyphenols for IBD therapy and a comprehensive perspective for implementing natural antioxidants as potential IBD candidate treatment.
Exploring the Impact of Social Identity on the Bullying of Construction Industry Apprentices
Authors: Greacen Peter , Ross Victoria
Published: August 2023

Background: There is a lack of literature specifically examining the workplace bullying of apprentices and trainees in traditional, male-dominated sectors such as the Australian building and construction industry. Using social identity theory (SIT), the aim of this study was to gather the attitudes, thoughts, and feelings of construction industry leaders to better understand how social identification (i.e., group membership) impacts bullying on targets and perpetrators, and the willingness to report bullying for targets and bystanders. Method: One-on-one, semi-structured interviews using a purposive sample of eight leaders from construction and blue-collar industries. Qualitative data were analysed using reflexive thematic analysis. Results: Four overarching themes were identified: difficulties for apprentices transitioning into industry, the need for continued improvement to industry culture, reluctance to report bullying, and rethinking apprenticeships to empower. Each theme provides insight into the psychosocial phenomenon of the bullying of trade apprentices and suggests that an apprentices’ level of social identification with work groups shapes how bullying is identified, interpreted, and prevented. Conclusion: Findings from this study will be important for tailoring evidence-based interventions, human resource policies and initiatives for education and awareness training. Themes also highlight systemic inadequacies impacting apprentices’ mental health and skill development, with implications for the future sustainability of apprenticeship training agreements.
Prolonged Inhibition of the MEK1/2-ERK Signaling Axis Primes IL-1β Expression through H3K9 Demethylation in Murine Macrophages
Authors: Low Rachel , Ha Soon-Duck , Sleapnicov Nichita , Maneesh Parthiv , Kim Sung ouk
Published: August 2023

Macrophages undergo different cellular states upon activation that can be hyporesponsive (tolerated) or hyperresponsive (primed or trained) to subsequent stimuli. Epigenetic modifications are known to play a key role in determining these cellular states. However, little is known about the role of signaling pathways that lead to these epigenetic modifications. Here, we examined the effects of various inhibitors targeting key signaling pathways induced by lipopolysaccharide (LPS) on tolerance and priming in the murine macrophages. We found that a prolonged inhibition (>18 h) of the MEK1/2-ERK signaling axis reversed tolerance and primed cells in expressing IL-1β and other inflammatory cytokines such as IL-6, TNFα, and CXCL10. Ectopic expression of catalytically active and inactive MEK1 mutants suppressed and enhanced IL-1β expression, respectively. Primed cells by the MEK1/2 inhibitor U0126 expressed higher levels of gene sets associated with immune responses and cytokine/chemokine production but lower levels of genes with cell cycle progression, chromosome organization, and heterochromatin formation than non-primed cells. Of interest, expression of the histone 3 lysine 9 (H3K9) methyltransferase Suv39h1 and the H3K9 methylation reader Cbx5 was substantially suppressed, whereas the H3K9 demethylase Kdm7a was enhanced, suggesting a role of the MEK1/2-ERK signaling axis in H3K9 demethylation. The H3K9 trimethylation levels in the genomic regions of IL-1β, TNFα, and CXCL10 were decreased by U0126. Also, the H3K9 methyltransferase inhibitor BIX01294 mimicked and overexpression of Cbx5 prevented the U0126 training effects in both RAW264.7 cells and bone marrow-derived macrophages. Collectively, these data suggest that prolonged inhibition of the MEK1/2-ERK signaling axis reverses tolerance and primed macrophages likely through decreasing H3K9 methylation levels.
Distance Learning Exit Economic Model
Authors: Gaidelys Vaidas , Čiutienė Rūta , Cibulskas Gintautas
Published: August 2023

At the beginning of 2020, with the onset of the pandemic, the traditional learning environment for learners drastically changed globally. Since then, most students/teachers have started and practiced distance and virtual learning/teaching. Thus, a technological breakthrough in virtual learning has followed. In connection with this, many countries worldwide have commenced allocating additional financing and funds for educational institutions' technological improvement and development. The long-term stay in distance learning has revealed and highlighted new problems students face: their knowledge level has decreased, they lack socialization skills, and they face psychological and physical health problems. Due to this negative impact on students, a need to research and evaluate how much the EU countries allocated to solve the distance learning-caused problems and what programs or models they prepared has emerged and encouraged further studies. The research has found that many countries increased their allocations very minimally, e.g., 0.0.1%, but some increased their available budgets to 32%. Notably, most countries did not separate distance learning exit funding from distance learning preparation funding. Based on the problems the countries saw, only a few states identified withdrawal from distance learning as a problem. Considering this, we set ourselves the goal to evaluate exit models from distance learning and allocated funding amounts.
The following objectives were planned to achieve the goal:
· to evaluate the global practice of exit from distance learning;
· to determine the scope of funding for pandemic management;
· to evaluate the amounts of funding allocated to manage pandemic-caused consequences and the GDP ratio.
Research methods: mathematical-statistical analysis, empirical analysis, and analysis of scientific literature.
The Effects of Various Hawthorn Vinegar Methods on Antioxidant Status and Lipid Profiles in Rats
Authors: Karakçı Deniz , Bakır Buket , Seyidoğlu Nilay , Yıkmış Seydi
Published: August 2023

The hawthorn fruit, a member of the Rosaceae family, is a medicinal plant with numerous therapeutic properties. It exhibits a wide range of variants, with Crataegus tanacetifolia being Turkey's most widely recognized species. The hawthorn fruit has various biological activities, including anti-inflammatory, antibacterial, antioxidant, immune-modulating, and anti-carcinogenic properties. Vinegar was produced from the hawthorn fruit and the techniques of pasteurization and ultrasound were employed to enhance the antioxidant capabilities and extend the shelf life. A total of 56 mature Wistar-Albino rats were allocated into seven groups and administered hawthorn fruit vinegar via oral gavage on a daily basis. The experimental groups were classified as pasteurized (HVP) and ultrasound (HVU) treated, with two different dosage levels (0.5 and 1 mg/kg), and a control group consisting of regular vinegar. The SOD, MDA, and CAT antioxidant levels were measured using the ELISA method in plasma and liver tissue samples. The total cholesterol, triglyceride, HDL, LDL, AST, and ALT values were quantified in commercially available kits. The levels of SOD and CAT in the plasma and liver were found to be significantly higher in the HVU1 group. In a manner akin to those mentioned, the HVU1 cohort exhibited the highest HDL value. The levels of LDL were comparably low in both the thermal pasteurized and ultrasound treatment groups. This finding agrees with HDL levels and is statistically significant (p≤0.05). There were significant expressions of both CAT and SOD in HVU groups in liver tissues immunohistochemically. The possible therapeutic effects of hawthorn vinegar may boost its antioxidant capabilities and contribute to an overall improvement in quality of life.
Approach of Supercritical Carbon Dioxide for the Extraction of Kleeb Bua Daeng Formula
Authors: Ngamkhae Nittaya , Monthakantirat Orawan , Chulikhit Yaowared , Maneenet Juthamart , Khamphukdee Charinya , Chotritthirong Yutthana , Limsakul Suphatson , Boonyarat Chantana , Pitiporn Supaporn , Kwankhao Pakakrong , Kijjoa Anake , Daodee Supawadee
Published: August 2023

Supercritical fluid extraction (SFE) is an innovative green technology for the extraction of phytochemicals from plants. Therefore, this study aimed to evaluate the application of SFE and to optimize the extraction condition of the Thai herbal formula, Kleeb Bua Daeng (KBD). A Box-Behnken design (BBD) with response surface methodology was used to determine the effect of extraction time, temperature, and pressure on response variables including extraction yield, total phenolic content (TPC), total flavonoid content (TFC), total carotenoid content (TCC) and total anthocyanin content (TAC) of KBD formula. The highest percentage extraction yield, TPC, TFC, and TCC of the extracts were 3.81%, 464.56 mg gallic acid equivalents/g extract, 217.19 mg quercetin equivalents/g extract, and 22.26 mg β-carotene equivalents/g extract, respectively. The results indicated that SFE is a suitable method of extraction for green recovery of some phytochemicals from the KBD formula.
Geopolymer Composites: Manufacturing of Sandwich Steel and Geopolymer Structures with Spray Technology without Formwork
Authors: Le Su Van , Pławecka Kinga
Published: August 2023

This research examines the fire resistance of geopolymer composites (GCs), formulated using alka-li-activated metakaolin and aluminum powder. The production method involves spray-coating carbon steel plates with fresh GCs, followed by a 28-day curing period at room temperature. Sub-sequently, fire performance and aging tests are conducted to evaluate fire resistance. The study investigates GC properties, including apparent density, bending strength, compression strength, thermal conductivity, porosity, and production cost. Morphological changes before and after fire and aging tests are analyzed using scanning electron microscopy (SEM). Results demonstrate GC foams' outstanding thermal insulation, providing up to 75 minutes of fire resistance with a 6 mm coating, reducing temperatures by 300 °C compared to uncoated steel. GCs exhibit a density of 670 kg/m³, thermal conductivity of 0.166 W/m·K, 68% porosity, and cost efficiency at 250 dollars per cubic meter. This study underscores the potential of foamed geopolymer coatings for effective and economical surface protection.
Impact of Perinatal Co-exposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs
Authors: Lahimer Marwa , Djekkoun Narimane , Tricotteaux-Zarqaoui Sophian , Corona Aurélie , Lafosse Isabelle , Ben Ali Habib , Ajina Mounir , Bach Véronique , BenKhalifa Moncef , Khorsi-Cauet Hafida
Published: August 2023

Emerging evidence has indicated the involvement of extra-hypothalamic kisspeptin and GnRHR in reproductive function. In this study, we evaluate if maternal exposure to the pesticide chlorpyrifos (CPF) and/or a high-fat diet (HFD) have an impact on the expression of kisspeptin and GnRHR in reproductive organ of offspring’s rats. 16 Pregnant rats are divided into 4 groups, control group (n=4), CPF group (4 rats exposed daily to 1/mg/kg/day), HFD group (4 rats randomly fed a 5,25 kcal/g HFD), co-exposed group (4 rats exposed to CPF and HDF). At postnatal development PND60, males and female offspring were sacrificed. The reproductive organs (ovary and testis) were removed and histological, immunohistological analysis and in silico quantification (software Tissuefax, HistoQuest) was assessed to investigate the impact of different treatment on kisspeptin and GnRHR expression in reproductive organs. The main outcomes of the study showed a significant decrease in rat offspring’s body weight in CPF group from PND30 andPND60 (p<0.05 and p<0.01, respectively). Histological analysis shows a significant increase in atretic follicle and abnormal testis structure with germ cell desquamation at CPF exposed group. The immunodetection quantification of protein shows a significant decrease in GnRHR and kisspeptin in HFD and CPF exposed group, respectively in testis rat offspring. Perinatal exposure to CPF and HFD exposure affect the reproduction function of rat offspring.
PM² or PRiSM—A Matter of Choice?
Authors: Marques Patrícia , Sousa Paulo Ferreira , Tereso Anabela Pereira
Published: August 2023

Sustainability has become increasingly important. Existing project management methodologies are underdeveloped in sustainability. PM² is a methodology developed by the European Commission that aims to provide solutions and benefits to organizations. However, it doesn't include sustainability in its guide, because it aims to be generic. PRiSMTM aims to make the project management process more sustainable, it is based on the P5™ standard that aims to align portfolios, programmes and projects with sustainability. The major difference between the two methodologies is their main objectives. PRiSMTM has P5 Impact Analysis and Sustainability Management Plan as the main differentiating deliverable compared to other approaches, including PM². The most cited characteristic of PM² was to include best practices from other bodies of knowledge, and in PRiSMTM and P5™, it was to be an extension of the Triple Bottom Line, as it also includes product and process. The CEO of the PM² Alliance believes that PM² aims to be generic and usable for any project, so a focus on sustainability would remove the "elasticity" of the methodology. However, users wishing to use PM² and consider sustainability can include it in the additional objectives and use the P5 Impact Analysis and Sustainability Management Plan.
Phenol-based Chemical Peeling Therapy for Cervico-vaginal Intraepithelial Neoplasia (CIN/VaIN)
Authors: Maehama Toshiyuki , Shimada Sumire , Sakamoto Jinichi , Shibata Takeo , Fujita Satoko , Takakura Masahiro , Takagi Hiroaki , Sasagawa Toshiyuki
Published: August 2023

Objective:
This study aimed to validate the use of liquid phenol-based chemical peeling therapy for cervico-vaginal intraepithelial neoplasia (CIN and VaIN), with the goal of circumventing obstetric complications associated with surgical treatment.

Methods:
A total of 483 eligible women diagnosed with CIN and/or VaIN participated in this study. Participants underwent phenol-based chemical peeling therapy every 4 weeks until disease clearance. Disease clearance was determined by negative Pap tests for four consecutive weeks. HPV genotyping was conducted at the onset of the study and after disease clearance in select cases.

Results:
Among the 476 participants (excluding those with cancer), the number of treatment sessions until CIN/VaIN clearance ranged from 2 to 49 (median = 7 sessions). Forty-five participants (9.4%) underwent surgical treatments. Seven participants (1.5%) experienced recurrence, presenting with CIN2/VaIN2 or worse lesions; of these, three underwent LEEP, while four repeated the chemical peeling therapy. No obstetrical complications were noted among the 98 pregnancies following this therapy. The findings suggest that phenol-based therapy is safe and effective for CIN, although it requires numerous and lengthy treatments. Factors associated with resistance to this therapy include immune suppression, high-grade lesions, multiple HPV type infection, and direct or passive smoking.
Factors Affecting Nursing Practice of Physical Restraint Use among Clinical Nurses
Authors: Kim Jihyun , Yang Yaki
Published: August 2023

This study was aimed to identify perception, knowledge, attitude and nursing practice toward use of physical restraints among clinical nurses, and further examined the factors associated with nursing practice toward use of physical restraints. The research participants were 180 nurses from a urban general hospital located in Korea. Data were collected using self-report questionnaires and analyzed using t-test, ANOVA, Pearson correlation coefficients, and multiple regression. There were significant negative relationships attitudes towards the use of physical restraints with knowledge (r = -.32, p < .001) and nursing practice (r = -.12, p = .107). Knowledge showed a positive correlation with nursing practice (r = .28, p < .001). Factors affecting nursing practice of clinical nurses were identified as knowledge (β= .23), education experiences (Yes) (β= .18), and work unit (ICU) (β= .43). The explanation power of this regression model was 22% and it was statistically significant (F=7.45, p<.001). The findings from this study suggest that knowledge, education experiences and work unit were the strongest predictor on nursing practice toward use of physical restraints. Thus, we propose that developing and applying evidence-based educational intervention programs by work unit to reduce the inappropriate use of physical restraints in hospitals are required.
DNA Promoter Methylation of the ATM, APC, CDO1, RB1, TP53, WIF1 Genes in Patients with Head and Neck Squamous Cell Carcinoma
Authors: Kurevlev Segey , Aghjanayan Anna , Tskhovrebova Leyla , Gordon Konstantin , Polyakov Andrey , Ratushnyy Mikhail , Fatkhudinov Timur
Published: August 2023

Head and neck squamous cell carcinoma (HNSCC) takes the sixth place among the most common cancers in the world. Abnormal methylation can be one of the reasons for this cancer. The aim of this study was to investigate the DNA promotor methylation status of cancer-associated genes (ATM, APC, CDO1, RB1, TP53, WIF1) in patients with HNSCC. Bisulfite Conversion and Methylation-Sensitive High-Resolution Melting was used for analysis of the DNA methylation level of normal and tumor tissues in 44 patients. There were significant differences in DNA methylation level between patient’s tumor and normal tissues for CDO1 and WIF1 genes in all subjects and subgroups (p<0.05). In T3 subgroup there was significant correlation between CDO1 gene methylation and age in the normal tissue. The same correlation was detected also for the WIF1 gene methylation in tumor tissue samples in the subgroup with T3 and in normal tissue samples in the subgroup with T4 (p<0,05). In all genes no significant differences were found between the subgroups (T2, T3, T4 stage, primary/recurrent lesion, non-keratinizing/keratinizing SCC, age before/ after 50, smokers/non-smokers) of the patients. Thus, changes in the expression of the CDO1 and WIF1 genes can affect mechanisms of the occurrence and development of HNSCC.