bluuebunny/crossref_metadata_2025 huggingface dataset:
Tactile Social Recognition in Octopuses
Authors: Morse Peter , Huffard Christine
Published: March 2022

Social recognition is the ability of individuals in a species to differentiate among conspecifics based on their identity or biologically meaningful demographic. Despite evidence that they have sophisticated brains, complex behavioural repertoires, and acute sensory processing, surprisingly little is known about mechanisms aiding social recognition in cephalopods. This class’s unique chemotactile sense by the ventral arm surfaces gathers considerable information used in predator-prey interactions. Does it also help mediate social interactions? This study utilised 366 hours of focal animal observations to assess the likelihood of Hapalochlaena maculosa, a nocturnal species, to retreat after physically contacting conspecifics based on their sex, familiarity and mating history. Females retreated from both sexes equally, while males were more likely to retreat after contacting female conspecifics. Most conspicuously, males were significantly more likely to retreat after contacting females with which they had already mated. These findings provide the first evidence for chemotactile sex discrimination and mate recognition within cephalopods, and supplement previous observations that male H. maculosa do not appear to detect the sex of conspecifics from a distance. The decision to retreat from or stay with an individual based on their sex or mating history, only after physical contact, emphasises the importance of chemotactile behaviour in octopus sensory ecology and behaviour. Furthermore, male octopuses have limited spermatophore production, and the use of chemotactile social recognition observed here may highlight the importance of reproduction, specifically sperm allocation and avoidance of sexual cannibalism, on the evolution of sensory ecology and cognition within this lineage.
A novel inflammatory response-related signature predicts the prognosis of skin cutaneous melanoma and the effect of anti-tumor drugs
Authors: Xing Jiahua , Li Yan , Chen Youbai , Han Yan
Published: March 2022

Skin cutaneous melanoma (SKCM) is a skin cancer that is highly metastatic and aggressive, with a dismal prognosis. This is the first study to use inflammatory response-related genes to build a model and evaluate their predictive significance in SKCM. This study used public databases to download SKCM patients’ mRNA expression profiles and clinical data to create multigene prognostic markers in the UCSC cohort. We compared overall survival (OS) between high- and low-risk groups using the Kaplan-Meier curve and determined independent predictors using Cox analysis. We also used enrichment analysis to assess immune cell infiltration fraction and immune pathway-related activity using KEGG enrichment analysis. Finally, we detected prognostic genes’ mRNA and protein expression in SKCM and normal skin tissues using qRT-PCR and IHC (data from Human Protein Atlas). Finally, we developed a 5-gene predictive model that showed that patients in the high-risk group had a considerably shorter OS than those in the low-risk group. The analysis of the receiver operating characteristic (ROC) curve proved the model’s predictive ability. Furthermore, we conducted a drug sensitivity analysis and discovered that the expression levels of prognostic genes were substantially linked with cancer cell sensitivity to antitumor medicines. The findings show that the model we developed, which consists of five inflammatory response-related genes, can be used to forecast the prognosis and immunological state of cutaneous melanoma, giving personalized medicine and precision medicine a new goal and direction.
Numerical Simulation of Microstamping Process to Fabricate Multi-channel of SUS304 Thin Sheets with Consideration of Grain Structures
Authors: Si Shangyu , Wu Qiong , Mei Deqing , Mao Wenze , Song Shufan , Xu Liming , Zuo Tao , Wang Yancheng
Published: March 2022

The springback behavior of thin metal sheets will significantly affect the forming accuracy of microchannels during microstamping process, especially as the forming scale reduced to micro/meso levels due to the size effects and grain structures. This paper aims to study the size effects on springback behavior and microchannel’s formability in microstamping process. The thin sheet of SUS304 specimens with different grain sizes were prepared and employed in uniaxial tensile tests to examine the stress-strain relationship and used to study the effects of grain sizes on the material’s plastic deformation behavior. A constitutive model incorporate surface layer and grain structures is developed to characterize the deformation behavior of thin-metal sheet with different grain sizes. Then, the constitutive model is utilized in finite element simulation of microstamping process to fabricate microchannel structures, and the results are verified by experimental testing. Both numerical simulation and experimental results showed that the size effect is critical in microstamping process, the developed constitutive model is able to accurately characterize the global springback behavior of thin metal sheets during microstamping process.
A rare case of cervical squamous cell carcinoma combined with sinonasal inverted Papilloma: A case report
Authors: Hou Xiaoyu , Peng Chunrong , Zhang Guonan , Wang Dengfeng
Published: March 2022

Background: Cervical cancer is the fourth most common malignancy in women worldwide, and sinonasal inverted papilloma (SIP) is a rare benign sinus tumor and has the characteristics of destructive growth pattern, high recurrence rate and easy canceration. Cervical squamous cell carcinoma (SCC) combined with SIP has not been reported so far. Case Presentation: A 55-year-old woman was diagnosed with cervical SCC in our center and treated with concurrent radiochemotherapy. During the follow-up period, SIP was found twice and both underwent endoscopic left nasal tumor resection. The clues that the diseases were found were the abnormal rise of squamous cell carcinoma antigen (SCCA). SCCA level decreased to normal after operations.Discussion and Conclusion: (1) when the cervical lesions have resolved satisfactorily but the SCCA is still high, other sites should be promptly investigated for the cause, which may lead to earlier detection and earlier treatment of SIP. (2) Combined with the literature, we recommend that SCCA can be used as a routine monitoring index for SIP. If available, a combination of SCCA1 and SCCA2 can be tried for further judgement. (3) For SIP with a high recurrence rate, can anti-HPV treatment be taken after operation to reduce the risk of recurrence?
The Relationship Between Glycated Hemoglobin Level and The Stage of Periodontitis in Individuals Without Diabetes
Authors: Banjar Arwa , Alyafi Rusha , Alghamdi Ali , Assaggaf Mohammed , AlMarghalani Ammar , Hassan Shaymaa , Mealey Brian
Published: March 2022

Background: Glycemic control appeared to have a significant impact on the relationship between periodontitis and diabetes. Since the classification of periodontitis was updated, the current study aims to investigate the association between the stage of periodontitis and HbA1c level in patients considered to be normoglycemic Methods:135 patients with no history of diabetes were included in the study. All patients received full mouth periodontal exam. Periodontal diagnosis was determined according to the 2017 World Workshop on the classification of periodontal disease. The glycemic state of patients was assessed using a chair-side HbA1c analyzer. Results:90 patients in the study were diagnosed with periodontitis. Higher average HbA1c were associated with the different stages of periodontitis (p <0.01). Most of the non-periodontitis patients were in the non-diabetes group (67%), while most of the periodontitis patients were in the undiagnosed pre-diabetes group (47% of the stages I and II group, and 44% of the stages III and IV group (p <0.001). Conclusion: Periodontitis patients are more likely to have undiagnosed dysglycemia. The elevation in HbA1c level was more evident in patients with stage III and Iv periodontitis. The result of this study suggests that patients with advanced periodontitis might be targeted for diabetes screening.
Pituitary Stalk Interruption Syndrome: Phenotype, Predictors, and Pathophysiology of Perinatal events.
Authors: Diwaker Chakra , Thadani Puja , Memon Saba Samad , Sarathi Vijaya , Lila Anurag Ranjan , Arya Sneha , Krishnappa Brijesh , Karlekar Manjiri , Patil Virendra , Shah Nalini , Bandgar Tushar
Published: March 2022

Purpose: There is limited data regarding Pituitary Stalk Interruption Syndrome (PSIS) from India. Moreover, the pathophysiological link between perinatal events and PSIS is unclear. We aim to elucidate the predictors of PSIS among patients with growth hormone deficiency (GHD) and perinatal events in PSIS by comparing cohorts of PSIS and genetically proven GHD without PSIS. Methods: Among 179 GHD patients, 56 PSIS and 70 genetically positive GHD (52-GHRHR, 15-POU1F1, and 3-PROP1) patients were included. Perinatal events, clinical anomalies, pituitary hormone deficiency, and imaging findings were recorded. We compared subgroup of PSIS-isolated GHD (PSIS-IGHD) with GHRHR-IGHD and subgroup of PSIS-combined pituitary hormone deficiency (PSIS-CPHD) with POU1F1/PROP1-CPHD. Results: PSIS patients (45 males, median age: 12.5 years) most commonly presented with short stature. At last follow up (median age: 17.35 years), gonadal (during pubertal-age), thyroid and cortisol axes were affected in 81.6%, 62.5%, and 62.5%. 10/13 (77%) of PSIS children with initial IGHD diagnosis manifested hypogonadism during pubertal age. Male predominance, sporadic presentation, clinical anomalies were significantly higher in both PSIS subgroups than the respective genetic subgroups. Breech presentation was higher in PSIS-CPHD than POU1F1/PROP1-CPHD (44.4% vs 5.5%, p=0.004). Neonatal hypoglycemia (22% vs. 0%, p=0.05) and jaundice (42 vs. 5%, p=0.004) were higher in PSIS-CPHD than PSIS-IGHD. Conclusion: Later age at presentation and frequent hypogonadism were observed in our PSIS cohort. Male sex, sporadic presentation, clinical anomalies, and breech presentation predicted PSIS at presentation. Breech presentation in PSIS is likely due to stalk interruption rather than hormonal deficiency.
Synthesis of Silver Nanoparticles Reduced by Bingol Propolis and Evaluation of Antioxidant, Cytotoxic and Anticancer Activities in PC-3 Cells
Authors: Dervişoğlu Gökhan , Darendelioğlu Ekrem , Aykutoğlu Gürkan , Ayna Adnan , KAYA BÜLENT
Published: March 2022

Green synthesis of silver nanoparticles (AgNPs) has been reported in several studies. However, no study focused on synthesis, characterization, and investigation of anticancer and antioxidant activities of AgNPs using Bingöl propolis. The morphology and physical properties of PrAgNPs (propolis-AgNPs) were characterized by UV-Vis spectrum of the characteristic silver surface plasmon resonance band, FTIR, XRD, SEM, zeta potential and DLS analysis. XRD and zeta potential analysis revealed a potential of-24.6 mV and formation of cubic crystals, with an average size of 3.45 nm, and a wide band at 420 nm was detected in UV-vis spectroscopy. The in vitro antioxidant capacities of PrAgNPs were evaluated by DPPH radical scavenging, metal chelating, and hydroxyl radical scavenging activities. The cytotoxicity and anticancer activities of ethanolic extract of propolis (EEP) and PrAgNPs were investigated on PC-3 cell lines by WST-1 assay and western blotting. The results demonstrated that PrAgNPs showed higher antioxidant activity than the EEP. The synthesized PrAgNPs were also shown to inhibit PC-3 cell proliferation. In the immunoblotting study, the expression of levels of apoptotic markers pro-caspase-3 and cytochrome c confirmed apoptosis induced by PrAgNPs. The current study reveals that green synthesized PrAgNPs possess antioxidant, anticancer, and apoptotic activities on human prostate cancer cell line PC-3 and pave the way for the possible treatment of the various cancers.
Measurement error risk for finger-cuff blood pressure after aortic valve replacement are aortic valve area index and heart rate; FloTrac vs ClearSight
Authors: Yahagi Musashi , Sasaki Momoko , Omi Kyuma , Tabata Koya , Yaguchi Yuichi
Published: March 2022

Purpose: The accuracy of ClearSightTM blood pressure measurements in patients with postaortic valve replacement may be inaccurate compared to intra-arterial pressure, the clinical risk of measurement discrepancy remains uncertain. This study aimed to determine the factors associated with errors in measurement. Methods: From October 2020 to November 2021, we collected 881 pairs of intra-arterial/ClearSight blood pressure measurements from 30 adults who underwent transcatheter aortic valve replacement. The agreement of ClearSight blood pressure with intra-arterial pressure was compared, and the clinical risk was evaluated by classifying measurement errors into zones A (no risk) to E (dangerous risk) using error grid analysis. Results: The bias and precision of ClearSight measurement were −4.88 ± 15.46 (mmHg) for systolic, 4.73 ± 8.95 (mmHg) for the mean and 9.53 ± 9.01 (mmHg) for the diastolic blood pressure. The proportions of measurement pairs in zones A were 88.0% for systolic BP and 71.2% for mean BP, respectively. Logistic regression analysis revealed that the risk of measurement error being outside zone A was heart rate [odds ratio, 1.24; 95% confidence interval, 1.15 to 1.35; p<0.001] for systolic and mean blood pressure, and aortic valve area index < 1.0 (cm2. m−2) [odds ratio, 1.62; 95% confidence interval, 1.21 to 2.16; p=0.02] for mean blood pressure.Conclusion: These findings could help to identify patients of unsuitable for ClearSight blood pressure measurement. Our results demonstrate that the small aortic valve area index and low cardiac index are risk factors for measurement error.
Comparative Analysis of Bioaccumulation of Cadmium, Lead, Chromium, Copper and Nickel in Wheat Crop
Authors: mazhar muhammad waqar , Irfan Muhammad , SAIF SAIRA , irum wajeeha
Published: March 2022

In this research, the comparative analysis of heavy metals has been studied. An experiment was conducted to determine heavy metals bioaccumulation in wheat as wheat is the staple cereal crop consumed as food globally. Abiotic stress disturbs the metabolic pathway of plants, and the bioaccumulation of the metals cause enzymatic degradation, reduction in photosynthesis, increased level of the ROS species. Comparative analysis of the Cd, Pb, Cr, Cu, and Ni was analyzed with the help of Inductively Coupled plasma optical emission spectrometry (ICP-OES). The results show that Ni has a maximum value of BCF in shoots and roots, whereas the Cr has maximum TF values. SOD and POD assays were performed to check the ROS level in the plants. The results show that plants increase their anti-oxidant enzymes for the scavenging of ROS produced against the bioaccumulation of heavy metals.
Time is of the essence: Past selves are not prioritized even when selective discrimination costs are controlled for
Authors: Englert Julia , von Lampe Karola , Morina Nexhmedin
Published: March 2022

The perceptual Self Prioritization effect (SPE) refers to an advantage in attending to stimuli associated with the self relative to those associated with another individual. In the perceptual matching task, arbitrary pairings between oneself and other persons, and a geometric shape need to be learned. Apart from the SPE, this task also produces high matching performance for a close other. While cognitive representations of past selves are sometimes viewed as resembling that of an intimate other, and while there is some evidence that other types of psychological closeness modulate the SPE, it remains unclear whether such prioritization effects extend to past selves. Previous experiments on this topic required participants to distinguish between different points in time within the same task, raising the possibility that potential past self-prioritization was masked by task difficulty. In our experiment, we address this potential confound by presenting N = 118 participants with a simpler version of the matching task. We re-investigated self-prioritization in perceptual matching under conditions of mental time travel to the past. In line with previous evidence, we found clear prioritization of present selves, which was evident in response times, accuracies and the efficiency of practice. Performance was consistently poorest for the past self, indicating not only a lack of privileged processing, but rather a relative de-prioritization. Performance was unaffected by either the proximity of the time period in question, nor by experimenter-induced re-imagining of the self. Our results do not support a perceptual prioritization of past selves. Time is of the essence: Past selves are not prioritized even when selective discrimination costs are controlled for
2-Group symmetries and their classification in 6d
Authors: Apruzzi Fabio , Bhardwaj Lakshya , Gould Dewi S. W. , Schäfer-Nameki Sakura
Published: March 2022

We uncover 2-group symmetries in 6d superconformal field theories. These symmetries arise when the discrete 1-form symmetry and continuous flavor symmetry group of a theory mix with each other. We classify all 6d superconformal field theories with such 2-group symmetries. The approach taken in 6d is applicable more generally, with minor modifications to include dimension specific operators (such as instantons in 5d and monopoles in 3d), and we provide a discussion of the dimension-independent aspects of the analysis. We include an ancillary mathematica code for computing 2-group symmetries, once the dimension specific input is provided. We also discuss a mixed 't Hooft anomaly between discrete 0-form and 1-form symmetries in 6d
Bubble instabilities of mIIA on AdS$_4\times S^6$
Authors: Bomans Pieter , Cassani Davide , Dibitetto Giuseppe , Petri Nicolò
Published: March 2022

We consider compactifications of massive IIA supergravity on a
six-sphere. This setup is known to give rise to non-supersymmetric
AdS_44
vacua preserving \mathrm{SO}(7)SO(7)
as well as G_22
residual symmetry. Both solutions have a round
S^6S6
metric and are supported by the Romans’ mass and internal
F_{6}F6
flux. While the \mathrm{SO}(7)SO(7)
invariant vacuum is known to be perturbatively unstable, the
G_22
invariant one has been found to have a fully stable Kaluza-Klein
spectrum. Moreover, it has been shown to be protected against brane-jet
instabilities. Motivated by these results, we study possible bubbling
solutions connected to the G_22
vacuum, representing non-perturbative instabilities of the latter. We
indeed find an instability channel represented by the nucleation of a
bubble of nothing dressed up with a homogeneous D2 brane charge
distribution in the internal space. Our solution generalizes to the case
where S^6S6
is replaced by any six-dimensional nearly-K"ahler manifold.
Pengaruh Kepercayaan Aplikasi Zomato dan Kepuasan Restoran Terhadap Intensi untuk Menulis Review Positif di Zomato
Authors:   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Gracia Ellene , Prawira Regina Febri ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Yosevina Christiana ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Murniadi Krishnamurti ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: March 2022

Review online telah menjadi sumber yang penting untuk industri F&B, dan relevansinya menjadi signifikan dengan banyak konsumen mengutilisasi electronic word-of-mouth (eWOM) untuk mengambil keputusan. CGM (consumer generated media) sebagai platform eWOM dalam industri F&B di Indonesia contohnya Zomato, Pergi-Kuliner, Qraved. Kredibilitas CGM membuat pengguna berkontribusi dengan menulis review dan berinteraksi. Faktor-faktor kepuasan konsumen di restoran adalah dasar untuk menghasilkan eWOM positif. Belum ada riset yang menggabungkan aspek kepuasan restoran dan kepercayaan Zomato dan pengaruhnya untuk menghasilkan intensi membuat review, maka riset ini berjudul “Pengaruh Kepercayaan Aplikasi Zomato dan Kepuasan Restoran Terhadap Intensi untuk Menulis Review Positif di Zomato”. Riset ini menjawab permasalahan pengaruh kepercayaan aplikasi Zomato dan kepuasan konsumen terhadap restoran terhadap intensi eWOM via Zomato. Dilandasi oleh teori Trust building model dan Satisfaction building model, penelitian kuantitatif ini menggunakan AMOS dengan teknik analisis data Confirmatory Factor Analysis. Variabel kepercayaan CGM terdiri dari: kredibilitas sumber, kualitas informasi, kualitas aplikasi. Kepuasan restoran terdiri dari: kualitas makanan, interaksi karyawan, suasana fisik restoran, persepsi kualitas restoran. Penelitian ini memiliki sembilan hipotesis. Hasil analisis terhadap 201 responden yang belum pernah menulis review menghasilkan dua hipotesis ditolak. Kualitas aplikasi menjadi penentu bagi pengguna untuk menulis review. Objek penelitian (restoran kelas menengah ke atas) membuat suasana fisik restoran bukan pengaruh dalam kepuasan restoran. Kesimpulan penelitian adalah pengaruh kepercayaan pada aplikasi Zomato terhadap intensi menulis review dinyatakan memiliki signifikansi. Pengaruh kepuasan pada sebuah restoran terhadap intensi menulis review dinyatakan tidak memiliki hubungan signifikan.
Características maternas e o impacto da prematuridade no recém nascido
Authors: Mazzetti Ana Clara , Apati Pinto Andreza Iolanda , Schubert Gelbcke Mirele , Carl Silva Jean , Vaichulonis Carla Gisele
Published: March 2022

O parto prematuro caracteriza-se pela ocorrência do nascimento entre 20 e 37 semanas de gestação, havendo uma repercussão clínica alarmante para o recém nascido e para a gestante. O objetivo do estudo foi avaliar o impacto da prematuridade relacionados ao recém nascido e às características maternas observadas em pacientes de baixo risco atendidos em uma maternidade pública da cidade de Joinville, Santa Catarina. Sendo um estudo caso-controle cuja população foi randomizada entre puérperas primigestas atendidas na Maternidade Darcy Vargas, no período de março de 2018 a fevereiro de 2019 contabilizando uma amostra total de 722 puérperas. Dessa forma, os fatores relacionados com o desfecho de prematuridade foram uso de drogas pela gestante e a diminuição de frequência de consultas pré-natais. Em relação aos fatores neonatais analisados que foram relacionados com a prematuridade: menor capurro, menores índices de apgar, baixo peso ao nascer, internação neonatal foram características que diferenciam os prematuros dos recém-nascidos a termo.
A Evolução histórica do estudo da anatomia: uma revisão bibliográfica
Authors: Diniz Julia , Ferreira Caldas Isabella , Vigilato Vital Mario , Ferreira Passos Maria Eduarda , Marques Ribeiro Matheus
Published: March 2022

A anatomia é a ciência que se destina a estudar macro e microscopicamente a constituição dos seres. Foi a partir dela que o conhecimento médico evoluiu excepcionalmente através dos séculos. A história da anatomia passa pela técnica de mumificação no Egito antigo, pelos filósofos gregos, pelas proibições religiosas da Idade Média, pela revolução de Darwin e pelos mais sofisticados aparelhos criados na modernidade. A anatomia foi ganhando cada vez mais espaço, como consequência do anseio da Medicina em entender o funcionamento do corpo humano e em transformar a qualidade de vida da sociedade.
Hemangiopericitoma intracraniano: relato de caso
Authors: Florenzano Neves Fernanda , Moreira Lara Thaís , Pereira Carvalho Ayla Jaqueline , Trovão Queiroz Aline
Published: March 2022

O hemangiopericitoma (HPC) e o tumor fibroso solitário meníngeo (TFS) são tumores considerados agressivos, unificados devido à uma alteração molecular em comum, sendo atualmente classificados de acordo com o seu fenótipo e sua taxa mitótica, estando divididos em grau I, II e III. Os TFS/HPCs intracranianos sofrem metástase para locais extracranianos a uma taxa de 11,6 a 69% em um período de até 10 anos após o diagnóstico inicial, possuindo um curso indolente, agressivo e com alto potencial de malignidade. O objetivo deste trabalho foi relatar um caso de hemangiopericitoma grau III. Paciente feminina, 48 anos, apresentando, em 2015, quadro de cefaleia, que progrediu em 2017, fazendo-a buscar atendimento médico, sem apresentar melhora com a primeira linha terapêutica estabelecida. Foi referenciada ao neurologista, onde foi evidenciada lesão cerebral no lobo temporal direito, associada a alterações neurológicas, com a paciente sendo encaminhada para o Instituto Estadual do Cérebro, onde foi diagnosticada com hemangiopericitoma grau III e tratada através da realização de ressecção total da lesão. O HPC é um tumor raro do sistema nervoso central, diagnóstico diferencial do meningioma, sendo capaz de reduzir drasticamente a taxa de sobrevida em pacientes diagnosticados com um alto grau, com o seu controle e diagnóstico sendo um desafio, tornando necessário haver maior difusão de conhecimento sobre o tema.
Sociedade disciplinar e sociedade de controle
Authors: Mello Mariana Rodrigues Gomes de , Andrade Ofélia Cristina Xavier de , Sabbag Deise Maria Antonio , Rosa Daniele Achilles Dutra da
Published: March 2022

A partir do século XVIII, a imposição do controle das principais instituições políticas e sociais à população passa a ocorrer precipuamente por meio de estratégias urbanísticas. A arquitetura revela o objetivo de disciplinamento dos corpos de modo a prepará-los para a inserção na incipiente sociedade capitalista, seja na forma das escolas, fábricas ou prisões. Objetivamos num primeiro momento refletir, por meio da trajetória histórica e arquitetônica da Biblioteca Pública Municipal de Marília, se a biblioteca antiga tem preponderância de uma instituição disciplinar; para, em um segundo momento, apresentar a arquitetura no novo prédio, verificando se o novo modelo de biblioteca pode evidenciar a transição do modelo disciplinar ao de controle. Metodologicamente, trata-se de uma pesquisa de natureza qualitativa, documental e bibliográfica, na qual utilizamos o método Análise de Conteúdo da Bardin para analisarmos categorias de entrevista. Para tanto, nos valemos um pouco do pensamento de Foucault e Deleuze acerca do tema, bem como o histórico, arquitetura e um pouco da organização das coleções da biblioteca em questão, nos espaços e tempos diferentes. Concluímos que a nova biblioteca não é melhor do que a anterior. Ela apenas se adequa melhor aos ditames dos novos tempos, com novas perspectivas sociais e tecnológicas. A antiga biblioteca teve uma função muito importante na história da cidade e dos seus usuários. Somente não estava mais apropriada ao século XXI, necessitando de novo aspecto e sentido.
A New Paradigm Shift in Antidepressant Therapy: From Dual-action
to Multitarget-directed Ligands
Authors: Rodríguez-Lavado Julio , Alarcón-Espósito Jazmín , Mallea Michael , Lorente Alejandro
Published: March 2022

Major Depressive Disorder is a chronic, recurring, and potentially fatal disease,
affecting up to 20% of the global population. Since the monoamine hypothesis was
proposed more than 60 years ago, only a few relevant advances have been made, with
very little disease course changing from a pharmacological perspective. Moreover, since
the negative efficacy of novel molecules is frequently reported in studies, many pharmaceutical
companies have put new studies on hold. Fortunately, relevant clinical studies
are currently being performed extensively, developing immense interest among universities,
research centers, and other public and private institutions. Depression is no longer
considered a simple disease but a multifactorial one. New research fields are emerging,
occurring a paradigm shift, such as the multi-target approach beyond monoamines. In
this review, we summarize antidepressant drug discovery aiming to shed some light on
the current state-of-the-art clinical and preclinical advances to face this increasingly devastating
disease.
Could Polyphenolic Food Intake Help in the Control of Type 2 Diabetes?
A Narrative Review of the Last Evidence
Authors: D'Angelo Stefania , Ferrara Luigi , Joksimovic Marko
Published: March 2022

Background:

Diabetes is one of the most serious global public health concerns, imposing
a significant burden on public health and socio-economic development, with type 2 diabetes
accounting for 90 percent of individuals with the disease (T2D).

Introduction:

Beyond the hereditary factor, there are several risk factors associated with the
development of this syndrome; the lifestyle plays an increasingly predominant role in the development
of the metabolic complications related to T2D and a significant role in the onset of this
syndrome is played by an unbalanced diet. Polyphenolic food is a plant-based food, including
vegetables, fruits, whole grains, tea, coffee, and nuts. In recent years, there has been growing evidence
that polyphenols, due to their biological properties, may be used as nutraceuticals and
supplementary treatments for various aspects of T2D. Polyphenols may influence glycemia and
T2D through hypoglycemic properties, such as reduced insulin resistance, reduced fasting blood
glucose, and glycosylated hemoglobin value. Based on several in vitro, animal models, and some
human studies, it has been detected that polyphenol-rich products modulate carbohydrate and lipid
metabolism, attenuate hyperglycemia, dyslipidemia, and insulin resistance, improve adipose
tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and
inflammatory processes.

Methods:

This manuscript summarizes human clinical trials conducted within the last 5 years
linking dietary polyphenols to T2D, with a focus on polyphenolic foods found in the Mediterranean
diet.

Results:

Intaking polyphenols and their food sources have demonstrated beneficial effects on insulin
resistance and other cardiometabolic risk factors. Prospective studies have shown inverse
associations between polyphenol intake and T2D. The Mediterranean diet and its key components,
olive oil, nuts, and red wine, have been inversely associated with insulin resistance and
T2D.

Conclusion:

In conclusion, the intake of polyphenols may be beneficial for both insulin
resistance and T2D risk. However, other human clinical studies are needed to evaluate the
suitable dose and duration of supplementation with polyphenolic food in T2D patients.
Drug Repurposing Strategies for Non-cancer to Cancer Therapeutics
Authors: Singhal Shipra , Maheshwari Priyal , Krishnamurthy Praveen Thaggikuppe , Patil Vaishali M.
Published: March 2022

Global efforts invested in the prevention and treatment of cancer need to be repositioned to develop safe,
effective, and economic anticancer therapeutics by adopting rational approaches of drug discovery. Drug repurposing is
one of the established approaches to reposition old, clinically approved off-patent noncancer drugs with known targets
into newer indications. The literature review suggests a key role of drug repurposing in the development of drugs intended
for cancer as well as noncancer therapeutics. A wide category of noncancer drugs such as, drugs acting on CNS,
anthelmintics, cardiovascular drugs, antimalarial drugs, anti-inflammatory drugs, have come out with interesting outcomes
during preclinical and clinical phases. In the present article, a comprehensive overview of the current scenario
of drug repurposing for the treatment of cancer has been focused. The details of some successful studies along with
examples have been included followed by associated challenges.
Solid Lipid Nanoparticles: Peculiar Strategy to Deliver Bio-Proactive
Molecules
Authors: Minocha Neha , Sharma Nidhi , Verma Ravinder , Kaushik Deepak , Pandey Parijat
Published: March 2022

Background:

Novel Drug Delivery Systems (NDDS) provide numerous benefits compared
to conventional dosage forms. Poor aqueous solubility, low bioavailability, frequent dosing, and particular
hydrophilic lipophilic character of the drug are the biological factors associated with the traditional
systems leading to the development of SLNs.

Objective:

For improving the solubility profile, enhancing the bioavailability, and attaining the best
possible therapeutic effect of lipid inclined or aqueous inclined drug, formulating solid lipid nanoparticles
is the best choice.

Methods:

Solid Lipid Nanoparticles (SLNs) have been projected as a colloidal carrier system with a
size of 50–1,000 nm, collectively combining the benefits of other colloidal systems like liposomes,
emulsions, etc., for delivering the drug at the target site. High absorption, high stability, and efficient
drug packing enhance the pharmacokinetic and pharmacodynamic properties of the packed drug.

Result:

Solid Lipid Nanoparticles can be developed in different dosage forms and administered via
routes such as nasal, rectal, oral, topical, vaginal, ocular, and parenteral. They have higher physicochemical
stability and the batch size can be easily scaled up at a low cost. Lipophilic as well as hydrophilic
drugs can be easily incorporated into solid lipid nanoparticles.

Conclusion:

In this manuscript, the authors have reviewed different aspects of solid lipid nanoparticles,
major principles behind mechanism methods, recent patents, applications, and therapeutic potentials
of solid lipid nanoparticles.
Standard Triple Therapy as a Remedy for Treatment of Helicobacter pylori
Infection: A Systematic Review and Meta-analysis of Randomized Clinical
Trials
Authors: Hoseini Jalal Eshagh , Kiani Faezeh , Khademolhosseini Sara , Fathi Mobina , Tavasol Arian , Mohammadi Jasem , Dousti Majid
Published: March 2022

Background:

H. pylori infection, one of the most prevalent infectious diseases, can cause
severe health problems. Therefore, it seems to be crucial to effectively counter the H. pylori infection
with a well-tolerated eradication regimen. However, since the discovery of H. pylori, the optimal
treatment for this disease is still unclear and remains controversial.

Objectives:

The present study aims to estimate the efficacy of standard triple therapy for eradicating
H. pylori by systematic review and meta-analysis.

Methods:

We identified randomized clinical trials [RCTs] involving triple therapy PPIAC/M
[Omeprazole, Amoxicillin, and Clarithromycin/Metronidazole] in the first-line treatment of H. pylori
infection and reported eradication rate through electronic and manual searches in PubMed, ISI, EMBASE,
the Cochrane Central Register, and Scopus databases. Data were analyzed using the random
effect model, and the Cochrane Q test and I2 statistics were used to assess heterogeneity. Statistical
analyses were performed using STATA version 12.

Results:

Forty-seven RCTs [PPIAC: 40 RCTs and PPIAM: 7 RCTs] with 4,938 patients selected as eligible
for the final analysis. Per-protocol eradication rate was 80% [95% CI: 74-84] and 80% [95% CI:
73-87] for PPIAC and PPIAM regimens, respectively. The eradication rate for PPIAC and PPIAM
regimens was 83% [95% CI: 70%-95%] and 83% [95% CI: 75%-90%] and also 77% [95% CI: 68%-
88%] and 78% [95% CI: 69%-88%], respectively. Based on different treatment durations, the pooled
estimates of PP [per-protocol analysis] treatment outcomes were found the highest in 14-day treatment
in both regimens.

Conclusion:

Standard triple therapy PPIAC/M is recommended to be an effective and safe regimen,
although adequate data are not available to suggest PPIAC/M as the first-line therapy for H. Pylori infection.
Interestingly, our analysis demonstrated that PPIAC/M regimens were more effective in Asian
than European populations.
Effects of COVID-19 on Physical Activity and Its Relationship With Mental Health in a US Community Sample: Cross-sectional, Convenience Sampling–based Online Survey
Authors: Zhang Wei , Velez Dominick
Published: March 2022

Background

COVID-19 restrictions may make it difficult for people to engage in the recommended amounts of physical activity (PA).

Objective

The influence of the COVID-19 pandemic on PA, as well as the links between PA and mental health, was investigated in this study.

Methods

Participants were recruited using convenience sampling and responded to an online survey between April 15 and July 1, 2021, with ages ranging from 18 to 24 years (n=156, 40.9% of the sample) to ≥55 years (n=28, 7.4% of the sample). To assess general psychological distress, depression, anxiety, and pandemic anxiety, a battery of mental health assessments was used. The International Physical Activity Questionnaire - Short Form was used to collect PA data from participants, who were then classified as inactive, minimally active, or highly active. Participants also indicated the locations where they performed PA before and during COVID-19.

Results

A sample of 381 individuals was included in this research. The logistic regression analysis results were interpreted as odds ratios (ORs), where an OR higher than 1 indicated a greater chance of an event occurring and an OR less than 1 implied a lower likelihood of an event occurring. Logistic regression results revealed that inactive individuals were more likely to develop psychological distress (OR 2.17, 95% CI 1.27-3.69, P=.004), depression (OR 3.81, 95% CI 1.92-7.57, P<.001), and anxiety (OR 1.86, 95% CI 0.99-3.47, P=.05) as compared to highly active individuals. Furthermore, when compared to highly active people, those who were only minimally active had a higher risk of depression (OR 2.14, 95% CI 1.05-4.33, P=.04). Wilcoxon signed-rank tests revealed that COVID-19 has a greater impact on reducing the chances of less active individuals engaging in PA outside and in public spaces. Highly active people's physical exercise locations had changed less, and their exercise frequency at home increased.

Conclusions

Programmatic and policy interventions geared particularly toward enhancing PA among those less active may be a helpful strategy for addressing the worldwide pandemic’s mental health crisis.
Mobile-Based Self-management Application Requirements for Patients With Gastric Cancer: Quantitative Descriptive Study of Specialist and Patient Perspectives
Authors: Yazdanian Azade , Mehdizadeh Hamed , Balaghafari Azita , Kahouei Mahdi , Masoudinezhad Maede
Published: March 2022

Background

Gastric cancer is one of the most common gastrointestinal cancers. Patients with gastric cancer experience disabilities and complications that lead to reduced quality of life. Empowering these patients by providing them with information and self-management skills can help reduce side effects and improve their quality of life.

Objective

The aim of this study was to identify the user requirements for developing a mobile-based self-management app to support patients with gastric cancer.

Methods

Data were analyzed using descriptive statistics and frequency distribution reports using IBM SPSS Statistics software.

Results

All of the data elements and functional requirements except “data recording times” and “weight changes in graphs” were identified as essential by clinical experts and patients. Among the functional requirements required in a gastric cancer self-management app, the capabilities related to informing, announcing warnings, and reminders are included. In the demographic data section, most patients (14/26, 53%) did not comment on the importance of recording data such as name, surname, and place of residence, and the demographic data section was met with less agreement from patients than clinicians.

Conclusions

Applying the requirements mentioned in this study can improve the self-management of patients with gastric cancer. Such apps can play an important role in empowering patients and improving their quality of life. However, the apps need to be designed and implemented to see how they can meet users’ requirements.
Positive Peers mobile application use improves clinical outcomes for young people with HIV: A prospective observational cohort comparison (Preprint)
Authors: Step Mary M. , McMillen Smith Jennifer , Lewis Steven A. , Avery Ann K.
Published: March 2022

BACKGROUND

The Positive Peers mobile application (PPA) is a multi-function HIV support tool designed to improve HIV related clinical outcomes for young people with HIV (YPWH). This pilot study included testing the effectiveness of the app among a single clinic patient population.

OBJECTIVE

This study assessed the effects of PPA use on HIV clinical outcomes.

METHODS

PPA users were compared to study eligible non-users receiving care at the same clinic during the study period (n = 259). All study participants were between the ages of 13 and 34, diagnosed with HIV, and either returning to care after an absence, or diagnosed within 12 months prior to study enrollment. Participant demographics and HIV care variables were extracted from the electronic health record (EHR). The PPA user group (n = 114) consented to download the app which provided natively tracked application usage data.

RESULTS

Analysis showed that younger PPA users (13-24) were more likely to achieve sustained viral suppression than non-users (AOR 4.2, 1.2-13.9).

CONCLUSIONS

The Positive Peers mobile application appears to help younger users sustain HIV suppression. The freely available Positive Peers mobile application could be a helpful tool for achieving Ending the HIV Epidemic (EHE) goals.

CLINICALTRIAL

N/A
Identifying trusted sources of Lyme disease prevention information among internet users connected to academic public health resources (Preprint)
Authors: Kopsco Heather Lynn , Krell Rayda K. , Mather Thomas N. , Connally Neeta P.
Published: March 2022

UNSTRUCTURED

Misinformation about Lyme disease and other tick-transmitted pathogens circulates frequently online and can compete with, or even overshadow, science-based guidance on tickborne disease prevention. We surveyed internet users who are connected to academic tick resources to identify trusted sources of Lyme disease prevention information, explore tick bite prevention confidence, and examine associations of these responses with answers to common “hot button issues.” Eighty-three percent of respondents identified conventional experts (e.g. the Centers for Disease Control (CDC)) as trustworthy tickborne disease prevention resources, but nearly one quarter of subjects would first consult personal contacts and online communities. The opinions of public health experts and physicians were rated among the top motivators behind personal prevention decisions, yet more than 50% of subjects revealed distrustful attitudes toward CDC-supported statements related to Lyme disease transmission time, the safety of DEET-based repellents, and use of antibiotic prophylaxis. We found that self-reported social media usage in this group was positively correlated with first seeking traditional expert sources, but also increased rejection of CDC-promoted Lyme disease information. Employing strategies to improve public trust may improve prevention communication and adoption of best practices.
Thermophysical Properties of Beef Steaks Varying in USDA Quality Grade and Internal Temperature
Authors: Hernandez M. Sebastian , McClennan Jessie T. , Martini Silvana , Allen Karin , Ban Heng , Legako Jerrad F.
Published: March 2022

The objectives of this study were to determine the influence of quality grade and internal temperature on the thermophysical properties of beef strip steaks. Beef strip loins (n=24) were collected from USDA Prime (PR), Low Choice(LC), and Standard (ST) carcasses. Strip loins were fabricated into 2.54 cm steaks at 21 d postmortem and randomly assigned to an internal temperature (4°C, 25°C, 55°C, 60°C, 71°C, 77°C). Steaks were subjected to various thermal and physical property measurements. No quality grade × internal temperature interaction was observed for diffusivity and conductivity (P > 0.05). Steaks tempered to 25°C had the greatest conductivity compared with all other internal temperature treatments (P = 0.021). A quality grade×internal temperature interaction was observed for center myosin and sarcoplasmic protein enthalpy values (P < 0.001). Raw (4°C and 25°C) ST steaks had lower enthalpy values compared with raw PR and LC steaks (P < 0.05). Raw steaks had greater surface myosin and both center and surface actin enthalpy values (P < 0.05). A quality grade × internal temperature was observed for surface and center viscoelasticity (P < 0.05). Raw steaks possessed less elastic behavior compared with cooked steaks, regardless of quality grade (P<0.05). Quality grade and internal temperature impacted expressible moisture and water holding capacity (P ≤ 0.001). ST steaks possessed increased expressible moisture and water holding capacity compared with LC and PR steaks (P<0.05). A quality grade×internal temperature was observed for Warner-Bratzler shear force and springiness (P ≤ 0.008). Internal temperature impacted all texture profile analysis attributes (P < 0.05). PR steaks were more cohesive than ST steaks (P = 0.011). These data show that final internal temperature and USDA quality grade impact thermophysical properties of beef steaks.
Disco: Un Amor Pendiente. Cardencheros de Sapioriz. Editado por CONACULTA y distribuido por Fonarte Latino S.A. de C.V. 2015.
Authors: Garrido Rojas David
Published: March 2022

Una expresión del desierto que corrió el riesgo de desaparecer pero que cada día retoma fuerza, eso es el canto cardenche, un género musical tradicional a capela que se practica en Durango y cuyo principal objetivo es expresar el dolor sentimental. Esta tradición musical es el mejor ejemplo de cómo con sólo usar la voz se pueden transmitir, de forma muy certera, sentimientos tan fuertes como el desamor y la tristeza. Los Cardencheros de Sapioriz son uno de los principales resguardos de esta expresión, y quienes recientemente se han encargado de darla a conocer en todos los lugares y formas que les es posible.Este disco titulado Un Amor Pendiente es uno de esos esfuerzos. Es también, sin duda, un documento de audio sin comparación, no únicamente por la forma en la que se hace el canto cardenche, sino porque al escucharlo, realmente genera la sensación de pena y nostalgia de algún amor imposible o perdido. Así, es capaz de transportarnos a los paisajes desérticos donde fueron compuestas estas piezas.Son dieciséis las pistas que componen este material, de las cuales once pertenecen a los Cardencheros de Sapioriz. Las otras cinco son de músicos que han intentado retomar aspectos de este tipo de canto, tales como Iraida Noriega, el conjunto Acardenchados y Todd Clouser. En una de estas pistas se narra la historia del canto cardenche en la propia voz de quienes mantienen la tradición viva, algo que, con seguridad, representa un material oral de valor incalculable.

Se pueden escuchar algunas pistas del disco pulsando aquí.
Entrevista a Alejandro Hau (Nuevo Durango, Lázaro Cárdenas, Quintana Roo)
Authors: Granados Vázquez Berenice Araceli
Published: March 2022

Entrevistado: Alejandro Hau
Edad: 18 años
Ocupación: estudiante
Lugar de origen: Nuevo Durango, Quintana Roo
Fecha de la entrevista: 16 de julio de 2013
Lugar: Nuevo Durango, Quintana Roo
Duración de la grabación: 07:07 minutos
Transcripción: Berenice Granados
Interlocutor: Berenice Granados
Cámara y sonido: Berenice Granados
Revisión y transcripción: Quetzal Mata Trejo y Yotzin Nekis Viacobo Huitrón