bluuebunny/crossref_metadata_2025 huggingface dataset:
Survival benefit of radiotherapy after surgery in de novo stage IV breast cancer: a population-based propensity-score matched analysis
Authors: Kim Yi-Jun , Jung So-Youn , Kim Kyubo
Published: June 2019

The survival benefit from radiotherapy in stage IV breast cancer has not been fully evaluated. We investigated the survival benefit of radiotherapy after surgery inde novostage IV breast cancer. Using a population-based database (the Surveillance, Epidemiology, and End Results database 18, 2010–2013), patients diagnosed withde novostage IV breast cancer were divided into those undergoing surgery alone (no-radiotherapy group) and those undergoing surgery followed by radiotherapy (radiotherapy group). After propensity-score matching (PSM), the cancer-specific survival (CSS) rates were estimated. Multivariate analysis was performed to evaluate the prognostic value of radiotherapy on survival. After PSM, the 3-year CSS rates in the no-radiotherapy (n = 882) and radiotherapy (n = 882) groups were 57.1% and 70.9% (P < 0.001), respectively. On multivariate analysis, radiotherapy after surgery was a significant prognosticator (hazard ratio [HR] 0.572; 95% confidence interval [CI] 0.472–0.693, P < 0.001). Regardless of surgery type and lymph node involvement, the radiotherapy group showed significantly higher CSS rates. For patients who survived six months or more, radiotherapy after surgery demonstrated favorable prognosis compared to surgery alone (HR 0.593; 95% CI 0.479–0.733, P < 0.001). In conclusion, radiotherapy after surgery increased CSS rates inde novostage IV breast cancer compared to surgery alone.
Reliability and validity of a Central Kurdish version of the Dizziness Handicap Inventory
Authors: Zmnako Sherko Saeed F. , Chalabi Yousif Ibrahim
Published: June 2019

We cross-culturally adapted the Dizziness Handicap Inventory (DHI) into Central Kurdish dialect (DHI−CK) and verified its reliability and validity. A cross-sectional study was utilised to measure the impacts of vestibular disorders. Along with the DHI−CK, two comparators were introduced: the Visual Analogue Scale and the Clinical Test of Sensory Interaction and Balance. External and internal reliability were tested with intraclass correlation coefficient (ICC) and Cronbach’s alpha/composite reliability, respectively. Patients (n = 301; mean age = 44.5 ± 15.2 years; 59.8% women) presenting with vestibular symptoms for at least 30 days who were diagnosed with a vestibular disorder and healthy participants (n = 43; mean age = 42 ± 17.9 years; 62.8% women) (N = 344). The DHI−CK and its three sub-scales—Physical, Emotional, Functional—exhibited good to excellent external reliability: ICCs in the test-retest were 0.93, 0.88, 0.91, and 0.92, respectively. Cronbach’s alphas were 0.87, 0.71, 0.75, and 0.73, respectively. Convergent validity was supported by Spearman’s correlations between the DHI−CK and the comparators. The receiver operating characteristic curve analysis confirmed discriminating validity. The DHI−CK was cross-culturally validated. It is a reliable and valid tool that can be used by clinicians and researchers to quantify vestibular disorder outcomes in Kurdish-speaking populations.
Size and lipid modification determine liposomal Indocyanine green performance for tumor imaging in a model of rectal cancer
Authors: Bar-David Shoshi , Larush Liraz , Goder Noam , Aizic Asaf , Zigmond Ehud , Varol Chen , Klausner Joseph , Magdassi Shlomo , Nizri Eran
Published: June 2019

Localization of rectal tumors is a challenge in minimally invasive surgery due to the lack of tactile sensation. We had developed liposomal indocyanine green (Lip-ICG) for localization of rectal tumor. In this study we evaluated the effects of liposome size and lipid PEGylation on imaging. We used an endoscopically-guided orthotopic experimental rectal cancer model in which tumor fluorescence was determined at different time points after intravenous (i.v.) administration of Lip-ICG and PEGylated liposomes (PEG-Lip-ICG). Signal intensity was measured by tumor-to-background ratio (TBR), or normalized TBR (compared to TBR of free ICG). Fluorescence microscopy of tumor tissue was performed to determine fluorescence localization within the tissue and blood vessels. Liposomes of 60 nm showed an increased TBR compared with free ICG at 12 hours after i.v. injection: normalized TBR (nTBR) = 3.11 vs. 1, respectively (p = 0.006). Larger liposomes (100 nm and 140 nm) had comparable signal to free ICG (nTBR = 0.98 ± 0.02 and 0.78 ± 0.08, respectively), even when additional time points were examined (0.5, 3 and 24 hours). PEG-Lip- ICG were more efficient than Lip-ICG (TBR = 4.2 ± 0.18 vs. 2.5 ± 0.12, p < 0.01) presumably because of reduced uptake by the reticulo-endothelial system. ICG was found outside the capillaries in tumor margins. We conclude that size and lipid modification impact imaging intensity.
Identification of specific protein amino acid substitutions of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli ST131: a proteomics approach using mass spectrometry
Authors: Nakamura Akihiro , Komatsu Masaru , Ohno Yuki , Noguchi Nobuyoshi , Kondo Akira , Hatano Naoya
Published: June 2019

The global pandemic of ESBL-producing Escherichia coli is associated with sequence type 131 (ST131). However, mechanisms of ST131 spread remain unclear. This study searched for proteins with amino acid substitutions specific for ST131 and used proteomics analysis to clarify ST131 characteristics. Five proteins had ST131-specific amino acid substitutions: uncharacterized protein YahO with E34A (m/z 7655); UPF0337 protein YjbJ with V59D, D60S and T63K (m/z 8351); uncharacterized protein YnfD with S106T (m/z 8448); and acid stress chaperone HdeA with Q92K and N94S (m/z 9714). Soluble cytochrome b562 (m/z 11783) showed seven amino acid substitutions, and the sequence differed between clade C of the pandemic clade and non-C. In silico analysis showed YahO protein-protein interaction with YjbJ, possibly related to biofilm formation. Although the function of soluble cytochrome b562 is electron transport of unknown function, its involvement in biofilm formation was predicted. HdeA was a gastric acid resistance-related protein. The function of YnfD was completely unclear. In conclusion, ST131-specific protein amino acid substitutions consisted mainly of a gastric acid resistance protein and proteins of unknown function (possibly involved in biofilm formation), which might be mechanisms for long-term colonization in the human intestinal tract.
Soybean soluble polysaccharides enhance bioavailability of genistein and its prevention against obesity and metabolic syndrome of mice with chronic high fat consumption
Authors: Lu Yalong , Zhao Aiqing , Wu Yingmei , Zhao Yan , Yang Xingbin
Published: June 2019

This study aimed to explore a novel strategy for the simultaneous consumption of soluble soybean polysaccharides (SSPS) and genistein to improve the bioavailability of genistein and its prevention against metabolic syndrome in obese mice.
Effect of sea-buckthorn pulp and flaxseed residues on quality and shelf life of bread
Authors: Guo Xin , Shi Longkai , Yang Shuai , Yang Roujia , Dai Xinyue , Zhang Tao , Liu Ruijie , Chang Ming , Jin Qingzhe , Wang Xingguo
Published: June 2019

Sea-buckthorn and flaxseed residues are high-value materials with potential application in bread-baking.
Evaluation of an alternative fluorinated chitosan as a QuEChERS adsorbent for pesticide residue analysis in apple samples
Authors: Deng Qilin , Sun Liping , Zhu Tao
Published: June 2019

In this study, a new and green fluorinated chitosan (trifluoroethyl methacrylate-chitosan (TFEMA-CTS)) was synthesized, and the QuEChERS method was applied for the effective determination of four pesticide residues in apple samples by high performance liquid chromatography.
ROS-sensitive biomimetic nanocarriers modulate tumor hypoxia for synergistic photodynamic chemotherapy
Authors: Liu Hang , Jiang Wei , Wang Qin , Hang Lifeng , Wang Yucai , Wang Yanmei
Published: June 2019

The biomimetic NPs@i-RBM have the potential to overcome hypoxia-limited PDT, and significantly improve the anticancer efficacy by synergistic PDT and hypoxia-activated chemotherapy.
Development of an antibacterial surface with a self-defensive and pH-responsive function
Authors: Zhang Jing , Zhu Wenhe , Xin Benkai , Lin Sue , Jin Libo , Wang Huiyan
Published: June 2019

In this work, a charge conversion mechanism was introduced to build a bacteria responsive antibacterial surface.
A guanylurea-functionalized conjugated polymer enables RNA interference in ex vivo human airway epithelium
Authors: Ahmed Md. Salauddin , Dutta Rajib Kumar , Manandhar Prakash , Li Xuerong , Torabi Hooman , Barrios Alfonso , Wang Ping , Chinnapaiyan Srinivasan , Unwalla Hoshang Jehangir , Moon Joong Ho
Published: June 2019

Positive charge modulation chemistry via the guanylurea group allows an efficient target gene knockdown in primary normal human bronchial epithelial cells covered with mucus.
Macromolecular helicity control of poly(phenyl isocyanate)s with a single stimuli-responsive chiral switch
Authors: Fukuda Mayu , Rodríguez Rafael , Fernández Zulema , Nishimura Tatsuya , Hirose Daisuke , Watanabe Go , Quiñoá Emilio , Freire Félix , Maeda Katsuhiro
Published: June 2019

The macromolecular helicity of poly(phenyl isocyanate)s can be tuned by a conformational switch of the chiral initiator through a domino effect.
Perfect planar tetra-coordinated MC6 monolayer: superior anode material for Li-ion battery
Authors: Lu Shaohua , Yang Chuncheng , Fan Dong , Hu Xiaojun
Published: June 2019

A hitherto unknown atomic-thin planar-structured transition metal carbide sheet denoted as MC6 (M = Cu, Ag, Au) is reported via a structure-swarm intelligence algorithm.
Citrem–phosphatidylcholine nano-self-assemblies: solubilization of bupivacaine and its role in triggering a colloidal transition from vesicles to cubosomes and hexosomes
Authors: Prajapati Rama , Larsen Susan Weng , Yaghmur Anan
Published: June 2019

In concentration- and lipid composition-dependent manners, bupivacaine triggers lamellar–nonlamellar phase transitions in citrem/soy phosphatidylcholine nanodispersions.
Metal-catalysed radical carbonylation reactions
Authors: Zhao Siling , Mankad Neal P.
Published: June 2019

A review of metal-catalysed radical carbonylation reactions is presented.
Current-density dependence of Li2S/Li2S2 growth in lithium–sulfur batteries
Authors: Kong Long , Chen Jin-Xiu , Peng Hong-Jie , Huang Jia-Qi , Zhu Wancheng , Jin Qi , Li Bo-Quan , Zhang Xi-Tian , Zhang Qiang
Published: June 2019

The current-density-dependent Li2S1/2 nucleation/growth was explored and this guiding principle was applied for the construction of high-efficiency Li–S batteries.
Monofloral honey from a medical plant,Prunella Vulgaris, protected against dextran sulfate sodium-induced ulcerative colitisviamodulating gut microbial populations in rats
Authors: Wang Kai , Wan Zhengrui , Ou Aiqun , Liang Xinwen , Guo Xiaoxuan , Zhang Zhongyin , Wu Liming , Xue Xiaofeng
Published: June 2019

Honey produced from medicinal plants hold great promise for human gut health.
Spatial, temporal, and spectral characterization and kinetic investigations of a high repetition-rate laser-induced micro-plasma in air
Authors: You Yi , Bierstedt Andreas , Riedel Jens
Published: June 2019

Fundamental investigations of low energy high repetition-rate laser-induced plasma.
The pivotal role of MBD4–ATP7B in the human Cu(i) excretion path as revealed by EPR experiments and all-atom simulations
Authors: Qasem Zena , Pavlin Matic , Ritacco Ida , Gevorkyan-Airapetov Lada , Magistrato Alessandra , Ruthstein Sharon
Published: June 2019

Copper's essentiality and toxicity require a meticulous mechanism for its acquisition, cellular distribution and excretion, which remains hitherto elusive. Herein, we jointly employed electron paramagnetic resonance spectroscopy and all-atom simulations to resolve the copper trafficking mechanism in humans considering the route travelled by Cu(i) from the metallochaperone Atox1 to the metal binding domains 3 and 4 of ATP7B. Our study shows that Cu(i) in the final part of its extraction pathway is most likely mediated by binding of Atox1 monomer to MBD4 of ATP7B. This interaction takes place through weak metal-stabilized protein–protein interactions.
Hydrogen generation from a sodium borohydride–nickel core@shell structure under hydrolytic conditions
Authors: Lai Qiwen , Alligier Damien , Aguey-Zinsou Kondo-François , Demirci Umit B.
Published: June 2019

Sodium borohydride (NaBH4) is an attractive hydrogen carrier owing to its reactivity with water: it can generate 4 equivalents of H2by hydrolysis (NaBH4+ 4H2O → NaB(OH)4+ 4H2).
Bacterial flagella as an osteogenic differentiation nano-promoter
Authors: Li Dong , Zhu Ye , Yang Tao , Yang Mingying , Mao Chuanbin
Published: June 2019

Flagella detached from the surface of bacteria can promote stem cell differentiation in osteogenic medium.
Co-delivery of paclitaxel and melittin by glycopeptide-modified lipodisks for synergistic anti-glioma therapy
Authors: Wang Huan , Wang Songli , Wang Ruifeng , Wang Xiaoyi , Jiang Kuan , Xie Cao , Zhan Changyou , Wang Hao , Lu Weiyue
Published: June 2019

Nanosized lipodisks with flat circular phospholipid bilayers surrounded by PEGylated edges have demonstrated promise in drug delivery.
Multicolor lanthanide-doped CaS and SrS near-infrared stimulated luminescent nanoparticles with bright emission: application in broad-spectrum lighting, information coding, and bio-imaging
Authors: Wang Jikai , Zhu Yanli , Grimes Craig A. , Cai Qingyun
Published: June 2019

Bright Ln3+-doped CaS/SrS near-infrared stimulated luminescent nanoparticles with variable fluorescent emission colors were successfully prepared.
Fluorescent sensor array for separation-free dopamine analogue discrimination via polyethyleneimine-mediated self-polymerization reaction
Authors: Sun Ye , Lu Fengniu , Yang Hongwei , Ding Caifeng , Yuan Zhiqin , Lu Chao
Published: June 2019

A fluorescent sensor array for separation-free dopamine analogue discrimination based on hyperbranched polyethyleneimine-mediated self-polymerization reaction is presented.
A NIR fluorescent probe for detection of viscosity and lysosome imaging in live cells
Authors: Chen Tong , Chen Zikang , Liu Ruiyuan , Zheng Shaobing
Published: June 2019

A D–π-A structure near-infrared fluorescent probe (Lyso-BTC) is explored for its fluorescence visualization and detection of lysosomes in view of a large Stokes shift (∼190 nm), NIR emission (685 nm), excellent photostability, fluorescence response to viscosity, and lysosome-targeted property.
Synthesis of well-defined glycopolymers with highly ordered sugar units in the side chain via combining CuAAC reaction and ROMP: lectin interaction study in homo- and hetero-glycopolymers
Authors: Liu Zhifeng , Zhu Yu , Ye Wenling , Wu Tong , Miao Dengyun , Deng Wei , Liu Meina
Published: June 2019

The design of novel heterogeneous glycopolymers with different sugar motifs is of critical importance in the glycopolymer field.
Boosting charge separation of Sr2Ta2O7 by Cr doping for enhanced visible light-driven photocatalytic hydrogen generation
Authors: Zeng Weixuan , Cao Sheng , Qiao Lulu , Zhu Anquan , Ma Quanyin , Xu Xiewen , Chen Yi , Pan Jun
Published: June 2019

Visible-light driven Cr-doped Sr2Ta2O7 nanosheets with enhanced photocatalytic performance were prepared by a facile hydrothermal method.
A one-pot protocol for the synthesis of β-ketosulfones from α,α-dibromoketones
Authors: Lin Bo , Kuang Jinqiang , Chen Jiajia , Hua Zhenguo , Khakyzadeh Vahid , Xia Yuanzhi
Published: June 2019

A one-pot debromination/sulfonylation strategy was developed for the direct transformation of α,α-dibromoketones into β-ketosulfones in the presence of sulfinate salts in a methanol solution.
A clinical and computational study on anti-obesity effects of hydroxycitric acid
Authors: Tomar Manu , Rao Raghavendra Prahlad , Dorairaj Palaniyamma , Koshta Abhishek , Suresh Sowbhagya , Rafiq Mohamed , Kumawat Rajesh , Paramesh Rangesh , V Babu U. , Venkatesh K. V.
Published: June 2019

Hydroxycitric acid (HCA), a major active ingredient ofGarcinia cambogiaextracts, is known to suppress body weight gain and fat synthesis in animals and humans.
MOF-5 derived carbon as material for CO2 absorption
Authors: Kukulka Wojciech , Cendrowski Krzysztof , Michalkiewicz Beata , Mijowska Ewa
Published: June 2019

In our study we prepared MOF-5 derived carbon to reveal the thermodynamics of CO2 absorption processes in great detail.
Biocatalytic transamination in a monolithic flow reactor: improving enzyme grafting for enhanced performance
Authors: van den Biggelaar Ludivine , Soumillion Patrice , Debecker Damien P.
Published: June 2019

Higher performance can be obtained in flow biocatalytic transamination reactions if the key parameters of support functionalization and of enzyme grafting are controlled.
Low density lipoprotein adsorption on a titanium surface and its effect on osteoblast behaviors
Authors: Xu Li-na , Shao Shui-yi , Zhu Wen-qing , Chen Chao , Zhang Song-mei , Qiu Jing
Published: June 2019

This study aims to investigate the adsorption of low density lipoprotein (LDL) on a titanium surface and to explore its effect on osteoblast behaviors.
Kinetically-controlled laser-synthesis of colloidal high-entropy alloy nanoparticles
Authors: Waag Friedrich , Li Yao , Ziefuß Anna Rosa , Bertin Erwan , Kamp Marius , Duppel Viola , Marzun Galina , Kienle Lorenz , Barcikowski Stephan , Gökce Bilal
Published: June 2019

The laser ablation of a bulk CoCrFeMnNi high-entropy alloy immersed in liquid yields colloidal nanoparticles with diameters below 5 nm. Both, the chemical composition and the crystal lattice of the bulk material is preserved in the nanoparticles.
Solubility model of metal complex in ionic liquids from first principle calculations
Authors: Karmakar Anwesa , Mukundan Rangachary , Yang Ping , Batista Enrique R.
Published: June 2019

A predictive model based on first principles calculations has been proposed to study the solid–liquid equilibria comprising of metal complexes and ionic liquids.
Assembly of 1H-isoindole derivatives by selective carbon–nitrogen triple bond activation: access to aggregation-induced emission fluorophores for lipid droplet imaging
Authors: He Dandan , Zhuang Zeyan , Wang Xu , Li Jiawei , Li Jianxiao , Wu Wanqing , Zhao Zujin , Jiang Huanfeng , Tang Ben Zhong
Published: June 2019

A method of selectively activating carbon–nitrogen triple bonds has been developed to access 1H-isoindole AIE fluorophores for lipid droplet imaging.
Combinatorial design of multimeric chelating peptoids for selective metal coordination
Authors: Ricano Abel , Captain Ilya , Carter Korey P. , Nell Bryan P. , Deblonde Gauthier J.-P. , Abergel Rebecca J.
Published: June 2019

The combinatorial synthesis of a new library of tetrameric peptoid ligands is introduced, enabling coordination and characterization of f-block metals.
Hammett neural networks: prediction of frontier orbital energies of tungsten–benzylidyne photoredox complexes
Authors: Chang Alexander M. , Freeze Jessica G. , Batista Victor S.
Published: June 2019

The successful application of Hammett parameters as input features for regressive machine learning models is demonstrated and applied to predict energies of frontier orbitals of highly reducing tungsten–alkylidyne complexes of the form W(CArR)L4X.
Improved efficiency of polymer solar cells by plasmonically enhanced photon recycling
Authors: Cho Seok Ho , Lee Sung-Min , Choi Kyung Cheol
Published: June 2019

A simple route to enhance the efficiency of polymer solar cells is presented by exploiting plasmonically assisted photon recycling. Embedded gold nanorods promote the photon radiation from excitons, and hence improve the effective diffusion length of excitons.
Unimpeded migration of ions in carbon electrodes with bimodal pores at an ultralow temperature of −100 °C
Authors: Wang Xi , Xu Jiang , Razal Joselito M. , Yuan Ningyi , Zhou Xiaoshuang , Wang Xuehang , Ding Jianning , Qin Si , Ge Shanhai , Gogotsi Yury
Published: June 2019

The ability to rapidly charge (and discharge) energy storage devices at extremely low temperature (down to −100 °C) is critical for low-temperature applications such as high altitude exploration and space missions.
A hydrophobic polymer stabilized p-Cu2O nanocrystal photocathode for highly efficient solar water splitting
Authors: Li Yang , Zhong Xiaolan , Luo Kai , Shao Zongping
Published: June 2019

For the first time, a compact hydrophobic layer composed of a macromolecular polymer was applied to inhibit the inactivation of cuprous oxide.
Photofunctional MOF-based hybrid materials for the chemical sensing of biomarkers
Authors: Yan Bing
Published: June 2019

The recent progress on the research of photofunctional MOFs based hybrid materials for chemical sensing biomarkers are summarized. Among the lanthanide functionalized MOFs hybrid materials by the author's group the emphasis for this review.
High-throughput sequencing reveals circular RNA hsa_circ_0000592 as a novel player in the carcinogenesis of gastric carcinoma
Authors: Liang Min , Liu Zhaoyu , Lin Hai , Shi Boyun , Li Ming , Chen Ting , Qin Lingyu , Niu Qiuling , Yu Guifang , Jiang Hui , Zhou Xinke
Published: June 2019

Background/Aim: Gastric cancer is one of the most common malignant tumors, and its complex pathogenesis has not been fully elucidated. Circular RNAs (circRNAs) are involved in various biological processes and human diseases. However, their exact functional roles and mechanisms of action remain largely unclear. We previously discovered the differential expression of non-coding RNAs (ncRNAs) during the malignant transformation of human gastric epithelial cells. In this study, we investigated the functional roles of a significantly up-regulated circRNA (hsa_circ_0000592) in gastric cancer. Methods:N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced malignant-transformed gastric epithelial cells (GES-1-T) and normal gastric epithelial cells (GES-1-N) were analyzed by high-throughput circRNA sequencing. The top 15 up-regulated circRNAs in high-throughput sequencing results were further confirmed by qRT-PCR in different gastric epithelial cell lines. The function of the most significant circRNA (hsa_circ_0000592) was investigated by using RNA interference (RNAi) assays, fluorescence in situ hybridization analysis (FISH), and bioinformatics prediction methods. Results: A total of 1509 genes were up-regulated and 3142 genes were down-regulated in GES-1-T cells when compared with GES-1-N cells. When compared with GES-1-N cells, hsa_circ_0000592 was obviously up-regulated in GES-1-T cells, as well as in other gastric cancer cell lines. The silencing of hsa_circ_0000592 mRNA led to a decrease in cell proliferation, cell cycle arrest at the G0/G1 phase, an increased rate of apoptosis, and a reduction in cell migration. Furthermore, FISH showed that hsa_circ_0000592 was mainly located in the cytoplasm, and a bioinformatics analysis suggested that hsa_circ_0000592 might function by sponging multiple miRNAs, and most notably four conserved miRNAs, including miR-139-3p, miR-200, miR-367-3p, and miR-33a-3p. Conclusion: This study is the first to identify hsa_circ_0000592 as a novel circRNA with a critical role in MNNG-induced gastric cancer. Due to the essential role of hsa_circ_0000592 in gastric carcinoma cells, it may be considered as a potential biomarker for use in diagnosing gastric carcinoma. Our findings provide a new insight into the function of circRNAs in environmental carcinogen-induced gastric cancer.
LncRNA ANRIL affects the sensitivity of ovarian cancer to cisplatin via regulation of let-7a/HMGA2 axis
Authors: Miao Jin-Tian , Gao Jian-Hua , Chen Yong-Qian , Chen Hong , Meng Hao-Yi , Lou Ge
Published: June 2019

This paper tried to explore ANRIL expression in ovarian cancer and how it affects cisplatin-sensitivity of ovarian cancer cells via regulation of let-7a/high-mobility group protein A2 (HMGA2) axis. qRT-PCR was used to detect ANRIL and let-7a levels in ovarian cancer tissues and cell lines (SKOV3 and SKOV3/DDP). Then cells were randomly assigned into Blank, negative control siRNA, ANRIL siRNA, let-7a inhibitor, and ANRIL siRNA+let-7a-inhibitor groups. CCK-8 assay was applied for assessing cell viability of cells treated with different concentrations of cisplatin. Flow cytometry was employed to test cell apoptosis rate. qRT-PCR and Western blot were performed for related molecules detection. Nude mice transplanted with SKOV3/DDP cells were used to confirm the effects of ANRIL siRNA on the cisplatin-sensitivity. Ovarian cancer tissues and cisplatin-resistant cells had increased ANRIL expression and decreased let-7a expression, and those patients with higher clinical stage and pathological grade showed higher ANRIL and lower let-7a. Dual-luciferase reporter-gene assay confirmed the targeting relationship between ANRIL and let-7a, and between let-7a and HMGA2. The cell viability and cisplatin IC50 were decreased in ANRIL siRNA group exposed to different concentrations of cisplatin, with enhanced apoptosis, as well as elevated let-7a and declined HMGA2, which would be reversed by let-7a inhibitor. Meanwhile, ANRIL down-regulation enhanced the inhibitory effect of cisplatin on tumor growth of nude mice and reduced tumor weight. Silencing ANRIL expression reduced HMGA2 expression to promote the apoptosis and improve cisplatin-sensitivity of ovarian cancer cells via up-regulating let-7a expression.
microRNA-613 exerts anti-angiogenic effect on nasopharyngeal carcinoma cells through inactivating the AKT signaling pathway by down-regulating FN1
Authors: Gao Ru , Feng Qiaolei , Tan Guolin
Published: June 2019

Background: Nasopharyngeal carcinoma (NPC) is a disease highly sensitive to radiotherapy with the unclear etiology. However, the specific effects of microRNA-613 (miR-613) on NPC still remain elusive. Therefore, the present study probes into the underlying mechanism of miR-613 in NPC via AKT signaling pathway by regulating Fibronectin 1 (FN1).

Methods: First, microarray analysis was used to screen differentially expressed genes (DEGs) and regulatory miRs associated with NPC. Next, miR-613 and FN1 expression in NPC cells was determined, followed by verification of target relationship between miR-613 and FN1. With NPC cells exposed to miR-613 mimic, si-FN1 and LY294002 (inhibitor of AKT signaling pathway), the regulatory effects of miR-613 on proliferation, apoptosis, invasion, migration and angiogenesis of NPC cells were detected with ratio of B-cell lymphoma 2/Bcl-2-associated X protein (Bcl-2/Bax), Cleaved-caspase3, matrix metallopeptidase 2 (MMP-2), MMP-9, vascular endothelial growth factor (VEGF), and cell adhesion molecule-1 (CD31) expression measured. Then, tumorigenesis and MVD were determined after Xenograft in nude mice.

Results: FN1 modulated by miR-613 was critical for NPC via the AKT signaling pathway. NPC cells exhibited down-regulated miR-613 and up-regulated FN1. Besides, miR-613 was verified to target FN1. Moreover, overexpressed miR-613, silenced FN1 or LY294002 treatment suppressed proliferation, invasion, migration, and angiogenesis in NPC cells, which was indicated by reduced expression of AKT, mTOR, MMP-2, MMP-9, VEGF, and CD31 as well as decreased ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3. Furthermore, cell apoptosis was promoted and tumorigenesis and MVD in nude mice were inhibited with overexpression of miR-613, silenced FN1 or LY294002 treatment.

Conclusion: Taken together, miR-613 inhibits angiogenesis in NPC cells through inactivating FN1-dependent AKT signaling pathway.
Energy efficiency of five broadcast‐based ARQ protocols in multi‐hop wireless sensor networks
Authors: Li Suoping , Dou Zufang , Wang Fan , Xu Qianyu
Published: June 2019

Achieving reliable and energy‐saving broadcast is the main issue discussed in this study. Firstly, a multi‐hop broadcast model is introduced, and the energy consumption and reliability of the network are defined in this study. Then five broadcast‐based automatic repeat request (ARQ) protocols (automatic retransmission N times, stop‐and‐wait end‐to‐end‐ARQ, stop‐and‐wait hop‐by‐hop‐ARQ, stop‐and‐wait hop‐by‐hop oriented implicit ARQ, stop‐and‐wait hop‐by‐hop implicit and explicit ARQ) are proposed to realise the reliable transmission. Secondly, based on five protocols, the relationship between the system reliability and the number of retransmissions of the root node is established analytically, and the maximum number of retransmissions is solved under the required system reliability. Thirdly, the energy consumptions of the root node are calculated, and then the analytical expressions of the minimum system energy consumption are obtained separately according to five broadcast‐based retransmission mechanisms. Finally, the relationships between the maximum number of retransmissions, energy consumption and reliability, the broadcast probability and feedback probability are discussed in the numerical analysis. Specially, for better energy‐saving, the modulation technique should be adopted to choose suitable protocol based on a dynamic hop threshold.
Hierarchical extended collaborative representation based classification for single‐sample face recognition
Authors: Yuan Yue‐Lai , Chen Di‐Hu , Hu Hai‐Feng , Du Ling‐Shuang
Published: June 2019

Collaborative representation based classification (CRC) has been widely used and shown good performance in face recognition (FR). Afterwards, hierarchical representation based classification has recently been proposed and aims to enhance the classification performance of the CRC method. However, these methods highly depend on the over‐complete dictionary comprised of sufficient training samples, and cannot be directly applied for single‐sample FR. In this study, the authors propose a novel CRC‐based FR framework to address this issue, which is named hierarchical extended collaborative representation based classification (HECRC). Firstly, they integrate hierarchical representation based model with low‐rank constrained variation dictionaries. Secondly, they select training samples that are the nearest neighbours of test images to obtain a more discriminative training dictionary, where an adaptive scheme is introduced to select proper samples automatically instead of setting a predefined number in traditional methods. Finally, the refined training dictionary and the learned variation dictionaries are jointly utilised to represent the test sample. Moreover, they combined the proposed HECRC with deep features to further improve the recognition rate. Experiments have been conducted on the AR and FERET datasets, and the results show that the proposed method has a substantial improvement over existing algorithms for single‐sample FR.
Enterprise architecture within railway systems engineering
Authors: Umiliacchi Silvia , Bhatia Davinder , Brownlee Andrew , Brown Colin
Published: June 2019

Owing to the complexity of the railway system, introducing new technologies or upgrading existing systems requires a whole system approach, ensuring effective integration and alignment with business needs. Enterprise architecture has been used to address this complexity, but there are currently no standardised enterprise architecture frameworks for the railway. The authors define an approach for building a whole railway system architecture framework by identifying architectural needs, analysing existing frameworks, and developing a proposed solution. The case study to support this work, taken from the GB Digital Railway programme, is an application of the proposed solution for producing requirements.
Sub‐mW cognitive CMOS frequency down‐converter for internet of things
Authors: Tedjini Sid Ahmed , Slimane Abdelhalim , Ghorbel Imen , Haddad Fayrouz , Rahajandraibe Wenceslas
Published: June 2019

In this study, a suitable sub‐mW frequency down converter for internet of things is presented. It is based on a single balanced switched transconductance mixer driven by a current‐reuse LC voltage controlled oscillator (LC‐VCO). For cognitive radio demonstration, the frequency converter is implemented with a tunable low‐noise amplifier (LNA) in 0.13 µm standard complementary metal oxide semiconductor (CMOS) technology. Post‐layout simulations return a gain conversion of 27 dB with a single‐sideband noise figure of 8 dB (LNA included) for a consumption of 0.97 mW under a voltage supply of 1.2 V and an active area of 0.4 mm2. The stand‐alone LC‐VCO prototype exhibits a measured phase noise of −102 dBc/Hz at 1 MHz offset while showing −114 dBc/Hz in the post‐layout simulation. The LC‐VCO measured power consumption is only 260 µW from 1 V voltage supply with an active area of 0.173 mm2.
Impact of geometrical parameters of micro-textured DLC on tribological properties under dry sliding friction
Authors: Shimizu Tetsuhide , Kan Hironori , Messaoudi Hamza , Vollertsen Frank , Yang Ming
Published: June 2019

To achieve a stable and high wear resistive functional surface under dry sliding friction, the present study proposes micro-textured diamond-like carbon coatings fabricated by ionized physical vapor deposition (I-PVD) using metallic masks. To clarify the suitable geometrical design under dry sliding friction, geometrical quantities of textured array patterns are varied by using metallic masks with different circular hole array patterns fabricated by picosecond pulsed laser processing. The effect of texturing on friction and wear properties is evaluated by ball-on-disk type friction tests for the condition of a constant DLC-coverage per unit area. Thereby, textured DLC pattern with diameters of 50 μm, 100 μm, and 150 μm are applied. Within the first 10 000 laps stable and lower coefficient of friction is obtained with the smallest diameters of 50 μm. However, at further rotation of more than 40 000 laps, the wear of the smaller diameters becomes more pronounced due to the increase of stress concentration at the edge of the structure. Based on these findings, geometrical design of micro-textured DLC coating is discussed with regard to the suppression of three-body plowing and the prevention of stress concentration.
Confectionery sunflower breeding and supply chain in Eastern Europe
Authors: Hladni Nada , Miladinović Dragana
Published: June 2019

Growing confectionery sunflower for consumption is becoming more and more attractive in the whole world. In Eastern European countries production, processing, and breeding of confectionery sunflower differ from oil-type sunflower. There is no precise information on the sowing areas of confectionery varieties and hybrids in Eastern European countries, mostly because, in statistical reports, sunflower producers do not provide separate data on the share of varieties in gross revenue of all manufactured products. Confectionery sunflower seeds are used in bakery products, but also in a number of natural health products and healthy snacks, as well as for direct consumption in the hull, dehulled, raw or backed form. Confectionery sunflower breeding is characterized by the fact that different markets have different demands when it comes to the seed size, hull colour, and other traits, which make this process more difficult and costlier. Market demands and production area of confectionery sunflower show a steady increase due to its nutritional value and use in human nutrition. In Eastern European countries, it is expected that the highly productive confectionery hybrids will replace varieties, which will lead to the increase of surfaces under this crop.
Traumatisches Stresserleben im Kontext körperlicher
Erkrankung und Behandlung
Authors: Goll-Kopka Andrea
Published: June 2019

Die Nichtbeachtung traumabezogenen Erlebens im Rahmen einer Erkrankung
verschlechtert den Heilungsprozess und die Prognose bis hin zur Mortalität.
Ein multimodales, körperbezogenes therapeutisches Vorgehen greift die
Erschütterungen im Bezug zum Körper und die strukturellen Veränderungen im
Selbsterleben auf. Eine familienbezogene Perspektive ist notwendig, da
Angehörige teilweise höhere Belastungswerte aufweisen. So wird
posttraumatisches Wachstum möglich.
Besondere Herausforderungen bei der psychotraumatologischen
Kausalitätsbeurteilung
Authors: Haenel Ferdinand
Published: June 2019

Traumaspezifische, die Exploration behindernde psychische Symptome und
besondere Einflüsse auf die Beziehung zwischen Gutachter und Probanden sowie
komorbide psychische Störungen stellen in der psychotraumatologischen
Begutachtung eine besondere Herausforderung dar. Sie sind Gründe, die zu
sehr unterschiedlichen Ergebnissen führen können. Der Artikel geht den
Ursachen anhand einer Kasuistik nach.
Kleine Traumata und das neue Konzept der
Anpassungsstörung
Authors: Bachem Rahel , Lorenz Louisa , Köllner Volker
Published: June 2019

Die Anpassungsstörung gilt als Verlegenheitsdiagnose und wurde aufgrund
diverser Validitätsprobleme lange Zeit kontrovers diskutiert. Ein neues
Störungskonzept im ICD-11 soll den bekannten Schwierigkeiten entgegentreten.
Zum ersten Mal werden spezifische Symptome für die Anpassungsstörung
definiert.
Trunk Muscle Aerobic Metabolism Responses in Endurance Athletes, Combat Athletes and Untrained Men
Authors: Anthierens Agathe , Olivier Nicolas , Thevenon André , Mucci Patrick
Published: June 2019

This study investigated aerobic metabolism responses in trunk muscles during a prolonged trunk extension exercise in athletes and untrained young men. The aim was to analyze the adaptations induced by 2 types of sports: one involving intensive use of trunk muscles (i. e., judo), and one known to induce high aerobic capacity in the whole body (i. e., cycling). Eleven judokas, 10 cyclists and 9 healthy untrained young men performed trunk extension exercises on an isokinetic dynamometer. During the first session, muscle strength was assessed during maximal trunk extension. During a second session, a 5-min exercise was performed to investigate aerobic responses with regard to trunk muscles. The near infrared spectroscopy technique and a gas exchange analyzer were used continuously to evaluate mechanical efficiency, V̇O2 on-set kinetics, trunk muscle deoxygenation and blood volume. Judokas showed greater trunk strength and mechanical efficiency (p<0.05). Cyclists presented faster V̇O2 on-set kinetics (p<0.05) and greater muscle deoxygenation and blood volume compared to untrained men (p<0.001). These results suggest that practicing judo improves trunk extension efficiency whereas cycling accelerates aerobic pathways and enhances microvascular responses to trunk extension exercise. Sport practice improves aerobic metabolism responses in trunk extensor muscles differently, according to the training specificities.
Heart–Lung Interaction
Authors: Kochhar Gaurav , Mehta Yatin , Trehan Naresh
Published: June 2019

Mechanical interplay between respiratory and cardiac systems was first recognized about 300 years ago when an English physiologist Stephen Hales observed that the level of the blood column in a glass tube inserted into the carotid artery of a horse varied cyclically with respiration.

Heart and lung share the same intrathoracic space, and mechanically this configuration is akin to pump within a pump. As a result, intrathoracic pressure (ITP) and volume changes during respiratory cycle affect the performance of heart. Besides direct mechanical effects, lung and heart interplay also involves certain neurally and humorally mediated phenomena. Taken together, these dynamics constitute heart–lung interaction. Knowledge of heart–lung interaction is especially useful while dealing with critically sick patients on ventilator, because not only are such patients more vulnerable to hemodynamic instability induced by ventilator, but it also forms the basis of functional hemodynamic monitoring.
Intracardiac Repair of the Tetralogy of Fallot Using Trans-right Atrial and Transpulmonary Approach: A Video Presentation
Authors: Sankhyan Lakshmi Kumari , Chowdhury Ujjwal Kumar , George Niwin , Chauhan Abhinavsingh , Kapoor Poonam Malhotra
Published: June 2019

Tetralogy of Fallot (TOF) is one of the common cyanotic heart diseases. Now total repair is increasingly being used to save children at younger age and having lower body weight. The aim of this study was to evaluate the results of the two different surgical techniques used for total repair of TOF: transatrial-transpulmonary approach and transventricular approach with special emphasis on pre- and intraoperative risk factors that affect the prognosis of patients, and with analysis of postoperative short-term results.
The Angelina Dissectors: A Novel Design of Dissectors for Endoscopic Endonasal Approaches
Authors: Todeschini Alexandre B. , Otto Bradley A. , Carrau Ricardo L. , Prevedello Daniel M.
Published: June 2019

Background The description and refinement of the transsphenoidal approach would not be possible without new tools and technologies developed by surgeons to facilitate this approach, which is nowadays the standard procedure for more than 90% of sellar lesions. The latest major change in transsphenoidal surgery was the introduction of the rigid endoscope and the subsequent description of the endoscopic endonasal approach. Traditional bayoneted instruments, when used for this technique, were inadequate. New instruments designed, specifically for this technique, are necessary to facilitate the surgeon's work and improve patient outcome.

Objective This study describes a novel design of dissectors created specifically for endoscopic endonasal approaches.

Methods To develop and design the Angelina dissectors, we used our extensive surgical experience to identify the shortcomings of the available dissectors used for transsphenoidal surgery and created the Angelina dissectors.

Results The Angelina dissector was designed with a unique shaft shape which facilitates endoscopic endonasal surgery.

Conclusion Even though an endoscopic endonasal approach is possible using other instruments, the design of these dissectors aids the surgeon's work. It is our impression, based on personal experience that it allows more freedom of movement and dexterity during the procedure, which could translate as an improved patient outcome.
Pflexit: „Operation mit ungewissem Ausgang“
Authors: Doelfs Guntram
Published: June 2019

Der Zeitplan ist sehr eng, das Volumen gewaltig: Bis Ende September soll die Selbstverwaltung in einem gewaltigen Kraftakt die Pflegepersonalkosten aus den DRG ausgliedern. Der milliardenschwere „Pflexit“ ist nicht nur technisch kompliziert. Er könnte so manche Klinik ab Anfang 2020 auch in finanzielle Nöte bringen.
Energiespar-Contracting: Win-win-Partnerschaft für die Umwelt
Authors: Kucera Martin
Published: June 2019

Die Universitätsmedizin Magdeburg setzt seit diesem Jahr auf ein neues Konzept zur Energieoptimierung im Rahmen eines sogenannten Energiespar-Contractings. Trotz umfangreicher Investitionen des Contracting-Partners fallen für den Kunden keine Mehrkosten an. Die deutliche Dezimierung der CO2-Emission verbessert auch die Umweltbilanz der Einrichtung.
Innovationsmanagement: Ozeanriesen im Jetski-Modus
Authors: Thalmayr Maria
Published: June 2019

Krankenhäuser sind wie Ozeanriesen – groß, sicher, solide, wenig anfällig für Störungen, kursstabil, damit aber leider auch alles andere als wendig. Wie können sie zum Jetski werden, ohne die Qualitäten eines großen Schiffes zu verlieren?
Light-trapping modes in lossy plasmonic waveguides
Authors: Anas Ibrahim Syed Muhammad , Kim Kyoung-Youm
Published: June 2019

Light-trapping modes can exist in lossless plasmonic waveguides. Here, we investigate the effect of metallic loss on light-trapping modes using the usual complex wave vector (β)-real frequency (ω) formulation and an alternative real β-complex ω formulation. It is shown that although their formation is prevented by metallic loss in the complex β-real ω formulation, light-trapping modes can exist even if there is metallic loss in the real β-complex ω formulation.
Volumetric spherical polynomials
Authors: Kerby L.
Published: June 2019

Researchers have found functional-based methods to improve data storage, transfer, and interpretation. These functional expansions have been developed and utilized across a range of geometries, from cartesian to cylindrical to the surfaces of spheres. However, a volumetric spherical basis set had not yet been computationally implemented. This paper presents such a basis set and demonstrates its numerical features and benefits.
Robust write operation in Co slotted nanoring
Authors: Zhou Kan , Wang Xiaokun , Zhuang Haiyan , Zhang Baoshan , Tang Dongming , Yang Yi
Published: June 2019

In magnetic random access memory (MRAM), free layers are used to store data bits as “0” or “1” in binary system. The main bottleneck limiting the practical applications of current MRAM technology is its storage states’ transition probability. Although several generations of MRAM have been reported, the problem still puzzles us. Here, we utilize an external field to switch Co slotted nanoring, which is convenient to reveal the key factor in the control of magnetic moments’ flip. Based on such analysis, we present a robust write operation through setting the slot edge parallel to the external field. In comparison with the probabilistic storage states’ transition in previous MRAM, our new technology definitely increases the switching probability to 100%. The continuous and orderly data-input process results in an energy barrier to protect the storage state. In addition, the robust write operation can also significantly reduce the influence of the device’s dimension on the switching probability, which is vital in decreasing the complexity and difficulty of the manufacture process. Besides, the novel data-input method could afford linearly tunable write parameters to satisfy the different application scenarios of storage devices.
Dynamic behavior of water droplets on wetted superhydrophobic surfaces under a high AC electric field
Authors: Wei Shichao , Jin Haiyun , Zhou Huimin , Yang Kunpeng , Gao Naikui , Li Wen
Published: June 2019

In this paper, the dynamic behavior of water droplets was investigated on wetted hydrophobic and surperhydrophobic surfaces under a high AC electric field. The droplets on superhydrophobic surface coalesced and slid off the inclined surface before the flashover occurred, while the droplets on hydrophobic surface stayed on the surface and could not roll off easily even under the breakdown field strength. Due to the behaviors of water droplets on the surfaces under the high AC electric field, the flashover voltage of the superhydrophobic surface was increased by 35.8 percent. A two-dimensional simulation model was developed to investigate the dynamic behavior of water droplets on surperhydrophobic surface. The results showed that, the adjacent water droplets were elongated and a liquid bridge was formed between the droplets under electric field. The coalescence of water droplets was impelled by the surface tension force and electric force.