bluuebunny/crossref_metadata_2025 huggingface dataset:
Erratum zu: Partizipatives Gesundheitsmanagement in der flexiblen Produktion: Entwicklung und Evaluation des teambezogenen Präventionskonzeptes SePIAR
Authors: Gerlmaier Anja
Published: July 2021

Ein Erratum zu dieser Publikation wurde veröffentlicht: 10.1007/s41449-020-00236-5
Impact of Land Cover Changes on Land Surface Temperature and Human Thermal Comfort in Dhaka City of Bangladesh
Authors: Imran H. M. , Hossain Anwar , Islam A. K. M. Saiful , Rahman Ataur , Bhuiyan Md Abul Ehsan , Paul Supria , Alam Akramul
Published: July 2021

Urbanization leads to the construction of various urban infrastructures in the city area for residency, transportation, industry, and other purposes, which causes major land use change. Consequently, it substantially affects Land Surface Temperature (LST) by unbalancing the surface energy budget. Higher LST in city areas decreases human thermal comfort for the city dwellers and affects the urban environment and ecosystem. Therefore, a comprehensive investigation is needed to evaluate the impact of land use change on the LST. Remote Sensing (RS) and Geographic Information System (GIS) techniques were used for the detailed investigation. RS data for the years 1993, 2007 and 2020 during summer (March–May) in Dhaka city were used to prepare land cover maps, analyze LST, generate hazard maps and relate the land cover change with LST by using GIS. The results show that the built-up area in Dhaka city increased by 67% from 1993 to 2020 by replacing lowland mainly, followed by vegetation, bare soil and water bodies. LSTs found in the study area were ranged from 23.26 to 39.94 °C, 23.69 to 43.35 °C and 24.44 to 44.58 °C for the years 1993, 2007 and 2020, respectively. The increases of spatially distributed maximum and mean LST were found 4.62 °C and 6.43 °C, respectively, for the study period of 27 years while the change in minimum LST was not substantial. LST increased by around 0.24 °C per year and human thermal discomfort shifted from moderate to strong heat stress for the total study period due to the increase of built-up and bare lands. This study also shows that normalized difference vegetation index (NDVI) and normalized difference water index (NDWI) were negatively correlated with LST while normalized difference built-up Index (NDBI) and normalized difference built-up Index (NDBAI) were positively correlated with LST. The methodology developed in this study can be adapted to other cities around the globe.
BIM usage benefits and challenges for site safety application in Indian construction sector
Authors: Hire Shalaka , Sandbhor Sayali , Ruikar Kirti , Amarnath C. B.
Published: July 2021

Construction industry is highly exposed to accidents than other industries. Due to the multi-disciplinary nature of the construction industry, more than one task is required to be performed at the same time. If safety planning is improper, it may lead to serious accidents on-site, directly affecting overall productivity. Recent technologies such as Building Information Modeling (BIM) have the potential to manage safety on the construction site. This study deals with the status check of the awareness of BIM in Indian construction along with benefits, barriers faced in Indian construction. This study also presents the benefits that BIM implementation can bring for safety management. In this study, a questionnaire was designed to ascertain the level of awareness of BIM in the Indian construction industry. The questionnaire was distributed to construction professionals from all over India. A total of 171 valid responses were received from all the corners of India. Statistical Package for the Social Sciences analysis (SPSS) has been used for data analysis. The survey concludes that the Indian construction sector needs to work on the three main aspects that include awareness of BIM and its benefits for organizations, accumulation of BIM in the tertiary education system, and delivering corporate training in construction organizations for a successful realization of benefits by the implementation of BIM.
On the Measure-Theoretic Premises of Bayes Factor and Full Bayesian Significance Tests: a Critical Reevaluation
Authors: Kelter Riko
Published: July 2021

The Full Bayesian Significance Test (FBST) and the Bayesian evidence value recently have received increasing attention across a variety of sciences including psychology. Ly and Wagenmakers (2021) have provided a critical evaluation of the method and concluded that it suffers from four problems which are mostly attributed to the asymptotic relationship of the Bayesian evidence value to the frequentist p-value. While Ly and Wagenmakers (2021) tackle an important question about the best way of statistical hypothesis testing in the cognitive sciences, it is shown in this paper that their arguments are based on a specific measure-theoretic premise. The identified problems hold only under a specific class of prior distributions which are required only when adopting a Bayes factor test. However, the FBST explicitly avoids this premise, which resolves the problems in practical data analysis. In summary, the analysis leads to the more important question whether precise point null hypotheses are realistic for scientific research, and a shift towards the Hodges-Lehmann paradigm may be an appealing solution when there is doubt on the appropriateness of a precise hypothesis.
A Systems View of Emotion in Socio-political Context
Authors: Leach Colin Wayne , Bou Zeineddine Fouad
Published: July 2021

Most work to date in psychology and related sciences has examined simple, unidirectional causal processes of emotion affecting socio-political context or vice versa. In this classic, mechanistic view of science, each empirical observation stands on its own as a piece of some grander, not yet understandable, puzzle of nature. There have been repeated calls to eschew classic approaches in favor of systems meta-theory in psychology and related sciences. In this paper, we join these calls by arguing that systems meta-theory can better enable the study of emotions in socio-political contexts. We offer a brief primer on systems meta-theory, delineating three key beneficial features: multi-leveled, complex, and dynamic. Viewing emotion as a system of systems—within the person, their relationships (to others), and within the world (locally and globally)—enables fresh theory, method, and statistical analysis well suited to the study of emotion in a socio-political context.
Artificial Intelligence in Education (AIEd): a high-level academic and industry note 2021
Authors: Chaudhry Muhammad Ali , Kazim Emre
Published: July 2021

In the past few decades, technology has completely transformed the world around us. Indeed, experts believe that the next big digital transformation in how we live, communicate, work, trade and learn will be driven by Artificial Intelligence (AI) [83]. This paper presents a high-level industrial and academic overview of AI in Education (AIEd). It presents the focus of latest research in AIEd on reducing teachers’ workload, contextualized learning for students, revolutionizing assessments and developments in intelligent tutoring systems. It also discusses the ethical dimension of AIEd and the potential impact of the Covid-19 pandemic on the future of AIEd’s research and practice. The intended readership of this article is policy makers and institutional leaders who are looking for an introductory state of play in AIEd.
Georg Simmel and German Culture
Authors: Podoksik Efraim
Published: July 2021

The significance of the German philosopher and social thinker, Georg Simmel (1858–1918), is only now being recognised by intellectual historians. Through penetrating readings of Simmel's thought, taken as a series of reflections on the essence of modernity and modern civilisation, Efraim Podoksik places his ideas within the context of intellectual life in Germany, and especially Berlin, under the Kaiserreich. Modernity, characterised by the growing differentiation and fragmentation of culture and society, was a fundamental issue during Simmel's life, underpinning central intellectual debates in Imperial Germany. Simmel's thought is depicted here as an attempt at transforming the complexity of these debates into a coherent worldview that can serve as an effective guide to understanding their main parameters. Paying particular attention to the genealogy and usage of the concepts of Bildung, culture and civilisation in Germany, this study offers contextual analyses of Simmel's philosophies of culture, society, art, religion and the feminine, as well as his interpretations of Dante, Kant, Nietzsche, Schopenhauer, Goethe and Rembrandt.
Crisis Prices: The Ethics of Market Controls during a Global Pandemic
Authors: Finestone Kobi , Kingston Ewan
Published: July 2021

SARS-CoV-2 has unleashed an unprecedented global crisis that has caused the demand for essential goods, such as medical and sanitation products, to soar while simultaneously disrupting the very supply chains that allow individuals and institutions to obtain those essential goods. This has resulted in stark price increases and accusations of price gouging. We survey the existing philosophical literature that examines price gouging and identify the key arguments for regulators permitting such behavior and for regulators restricting such behavior. We demonstrate how the existing accounts are designed for localized emergencies rather than global persistent crises such as the coronavirus pandemic. In light of this, we highlight an understudied justification for price gouging that is much more salient during global crises: incentivizing increased production of essential goods. Furthermore, we pinpoint three conditions that help determine whether authorities should restrict price gouging during the coronavirus pandemic and similar global crises.
InverseK-Chevalley formulas for semi-infinite flag manifolds, I: minuscule weights in ADE type
Authors: Kouno Takafumi , Naito Satoshi , Orr Daniel , Sagaki Daisuke
Published: July 2021

We prove an explicit inverse Chevalley formula in the equivariantK-theory of semi-infinite flag manifolds of simply laced type. By an ‘inverse Chevalley formula’ we mean a formula for the product of an equivariant scalar with a Schubert class, expressed as a$\mathbb {Z}\left [q^{\pm 1}\right ]$-linear combination of Schubert classes twisted by equivariant line bundles. Our formula applies to arbitrary Schubert classes in semi-infinite flag manifolds of simply laced type and equivariant scalars$e^{\lambda }$, where$\lambda $is an arbitrary minuscule weight. By a result of Stembridge, our formula completely determines the inverse Chevalley formula for arbitrary weights in simply laced type except for type$E_8$. The combinatorics of our formula is governed by the quantum Bruhat graph, and the proof is based on a limit from the double affine Hecke algebra. Thus our formula also provides an explicit determination of all nonsymmetricq-Toda operators for minuscule weights in ADE type.
Shock dynamics and shock collision in foam layered targets
Authors: Batani K. , Aliverdiev A. , Benocci R. , Dezulian R. , Amirova A. , Krousky E. , Pfeifer M. , Skala J. , Dudzak R. , Nazarov W. , Batani D.
Published: July 2021

We present an experimental study of the dynamics of shocks generated by the interaction of a double-spot laser in different kinds of targets: simple aluminum foils and foam–aluminum layered targets. The experiment was performed using the Prague PALS iodine laser working at 0.44 μm wavelength and irradiance of a few 1015 W/cm2. Shock breakouts for pure Al and for foam-Al targets have been recorded using time-resolved self-emission diagnostics. Experimental results have been compared with numerical simulations. The shocks originating from two spots move forward and expand radially in the targets, finally colliding in the intermediate region and producing a very strong increase in pressure. This is particularly clear for the case of foam layered targets, where we also observed a delay of shock breakout and a spatial redistribution of the pressure. The influence of the foam layer doped with high-Z (Au) nanoparticles on the shock dynamics was also studied.
The Ainu and Indigenous politics in Japan: negotiating agency, institutional stability, and change
Authors: Komai Eléonore
Published: July 2021

In April 2019, the Japanese government officially legally recognized the Ainu as Indigenous people. Building on an institutionalist framework, the paper suggests that a phenomenon of institutional layering has taken place, resulting in tensions between the desire to preserve the legitimacy of old institutions and the pressure to develop more progressive policies. To explain this process, policy legacies, and institutional opportunities are relevant. First, the narrative that equality can be attained through assimilation, and the political construction of the “Ainu problem” as a regional one tied to Hokkaido pervade political imaginaries and institutions. Second, institutional opportunities have mediated the ways activists have sought to make their voices heard in the political arena. A focus on key historical segments illuminates the difficulty for activists to penetrate high-level political arenas while indicating the importance of agency, ties and interests in explaining major reforms and their limitations. The ambiguity that characterizes current policy framework points to the potential leverage that this policy configuration represents for the Ainu. At the same time, historical and institutional legacies that have shaped Indigenous politics continue to constrain, to a great extent, the possibilities for meaningful and transformative developments for the Ainu.
The Refugee Camp as Site of Multiple Encounters and Realizations
Authors: Dalal Ayham
Published: July 2021

Literature in Human Geography has given much attention to “encounters” and their impact on negotiating difference in everyday life. These studies, however, have focused solely on cities, while “other” spaces like refugee camps have received little attention to date. In this paper, I highlight the significance of “encounters” in camps by exposing three main types: the “refugee-refugee,” the “refugee-humanitarian,” and the “refugee-more-than-human” encounters. Using empirical examples from Zaatari camp in Jordan, I show that the “refugee-refugee” encounters cannot be fully understood without taking refugees’ culture, background, and urban identities into consideration. I also explain how the “refugee-humanitarian” encounters result in new types of behaviors and might harden the boundaries between both groups. And lastly, I demonstrate how the “refugee-more-than-human” encounters can inform us about refugees’ unique experiences with shelters, space, and materiality. Building on the examples given for each type, this article suggests that “encounters” have the ability to generate knowledge and learnings, which contributes to shaping the space of the camp by either enforcing boundaries between different groups and/or by allowing new and hybrid spatialities to emerge. This not only confirms that “encounters” are an important entry point in understanding the socio-spatial and material composition of refugee camps, but also that further studies in this regard are direly needed. It also suggests that architects and planners need to allow for the “new” to emerge as a result of these encounters and, therefore, to enable flexibility and adaptability within camps’ design and planning.
Introduction to the Special IssuePluralism in Emergenc(i)es in the Middle East and North Africa
Authors: Batmanghelichi Kristin Soraya , Bajalia A. George , Al-Daghistani Sami
Published: July 2021

The issue “Pluralisms in Emergenc(i)es” is a result of a two-conference series that took place in Amman and Tunis, in December 2017 and October 2018, respectively. Taking these two locations as historical epicenters of human, commodity, and capital mobility, in two connected regions, these conferences set out to interrogate the historical, social, and religious underpinnings of the migrant and refugee crisis in order to position this moment as a state of emergence, rather than a state of emergency. The focus of the essays included here explores pluralism as it has emerged in response to contemporary global crises, and asks a number of questions: What are the variations in how “pluralism” is understood, and how does it function in a time of crisis? What are the material and immaterial modes through which pluralism takes shape? Moreover, how does it change through the circulation of people - as migrants, refugees, and asylum seekers – and capital – whether under the auspices of international development funds, religious aid, or new labor markets? By crossing disciplinary boundaries, this special issue enters into a fundamental discussion about how “pluralism” is conceived across sites and offers new vistas for its conceptualization in North Africa and the Middle East.
Politics and the Limits of Pluralism in Mohamed Arkoun and Abdenour Bidar
Authors: Dobie Madeleine
Published: July 2021

One of the striking features of the literary culture of the modern Maghreb is the profusion of works that undertake to identify the essential features of the region – exercises in definition that almost always emphasize plurality. Philosophers, social scientists, and literary writers have highlighted the Maghreb's multilingualism – the coexistence of different forms of Arabic, Tamazight, French, and Spanish – the varied and hybrid cultural legacies of conquest and colonialism, and the effects of the region's geographical proximity to other parts of Africa, Europe, and the Middle East. It would be hard to find a more ubiquitous theme of francophone Maghrebi literature than cultural diversity, and the subject is by no means absent from Arabic-language literature. This preoccupation with plurality can be seen as a response to a history of colonization and decolonization with particular ideological features. In their efforts to build “l'Algérie française,” the French colonial authorities suppressed Arabic as a language of culture and government. In response, anticolonial nationalists called for the replacement of French with Arabic. “Islam is my religion, Arabic is my language, Algeria is my nation” – the catchphrase of Abdelhamid Ben Badis's Jam'iyat al-'Ulama [Association of Muslim Ulema], an Islamic reform movement of the 1930s and 1940s – later became a slogan of the nationalist movement, the Front de libération nationale (FLN) [National Liberation Front]. Since the 1980s, a similar call to restore Arabic and eliminate French has been issued by the Islamist opposition to the corrupt and undemocratic FLN government and at times by officials in that same government seeking to restore their legitimacy. In emphasizing linguistic and cultural diversity, writers and scholars have tried to tender an alternative to these recurrent efforts to delimit the region's identity.
Theology and Philosophy of Pluralism
Authors: Diagne Souleymane Bachir
Published: July 2021

This essay is a reflection on the very notion of “pluralism” examined in a philosophical and theological approach. It evokes Quranic verses on pluralism and then examines the thoughts of different Muslim thinkers on the question, such as al-Farabi (d. 950), al-Ghazali (1058–1111) in the tenth and twelfth centuries, and Tierno Bokar Salif Tall (1875–1939), from Mali, in the twentieth.
On the Migrant Subject
Authors: Ziai Hengameh
Published: July 2021

Pluralism is deployed to govern migration across the Global North and Global South in contradictory ways. Fearing the arrival of migrants on its own shores – a threat to its biopolitical constitution – Europe deploys discourses of pluralism in the Global South to encourage migrants en route to Europe to sedentarize in “transit” countries like Sudan. Neoliberal development projects propagate the virtues of pluralism to host communities in Sudan, who are exhorted to view migrants as potential economic assets. Yet, in the context of Europe those same migrants continue to be seen as an economic and racial threat. While a lack of skills and entrepreneurialism are framed as the “root cause” of migration to Europe, migrants are paradoxically presented as trainable and therefore economically productive in the Global South. This article offers a critical examination of consolidating migration management practices in Sudan, their imbrication with development projects, and the racial anxieties they evoke in both Europe and in “transit” countries. It homes in on not only populations headed towards Europe, but those intending to remain in Sudan, notably Syrians, and explores the lessons and aporias of Sudan's hitherto open-door policy towards the latter.
New Student Films from Palestine: Dreamers and Dreams in the Classroom
Authors: Kalow Nancy
Published: July 2021

Palestinian student filmmakers based in the West Bank and Gaza tell stories of daily life in a collected set of short films which provide valuable insights for classes on the Middle East.
The Pale Death: Poison Gas and German Racial Exceptionalism, 1915–1945
Authors: Thompson Peter
Published: July 2021

In April of 1915, the German-Jewish chemist Fritz Haber supervised the first deployment of industrialized chemical weapons against French colonial troops. The uncertain nature of the attack, both in its execution and outcome, led many German military men to question the controllability of poison gas. Over the next three decades, Germans would continue this line of inquiry, as aero-chemical attacks appeared increasingly imminent. This article narrates the German search for control over chemical weapons between the world wars, revealing the ways in which interwar techno-nationalists tied the mastery of poison gas to ethno-racial definitions of Germanness. Under the Nazis, leaders in civilian aero-chemical defense picked up this interwar thread and promoted a dangerous embrace of gas that would supposedly cull the technically superior Germans from other lesser races. Although this vision of a chemically saturated world did not suffuse German society, such logic did play out in the gas chambers of the Holocaust.
RESILIENCE TECHNIQUES OF INTERNATIONAL COURTS IN TIMES OF RESISTANCE TO INTERNATIONAL LAW
Authors: Caserta Salvatore , Cebulak Pola
Published: July 2021

International courts are increasingly called upon to adjudicate socially divisive disputes. They are therefore exposed to a heightened risk of backlash that questions their authority and impedes the implementation of their judgments. This article puts forward an analytical framework for mapping the resilience techniques used by international courts to counter this growing resistance. Case studies involve the Court of Justice of the European Union, which has been cautious in its stance regarding democratic backsliding in Hungary and Poland, and the Caribbean Court of Justice, which has engaged in legal diplomacy while adjudicating both on the land rights of indigenous groups and on Lesbian Gay Bisexual Transgender Queer and Intersex (LGBTQI) rights. It is argued that, in order to effectively avoid and mitigate backlash, international courts should deploy resilience techniques that go beyond merely exercising their judicial function. The successful deployment of resilience techniques can allow international courts to become significant actors in global governance during a time of crisis for the international liberal order.
Crop succession and split-application of nitrogen effects on common bean yield in short no-tillage system
Authors: Mingotte F. L. C. , Jardim C. A. , Coelho A. P. , Yada M. M. , Leal F. T. , Souza S. S. , Lemos L. B. , Fornasieri Filho D.
Published: July 2021

Evaluating the effects of crop successions in no-tillage system (NTS) is essential for the correct recommendation of agronomic practices, such as top-dressing nitrogen fertilization. The aim was to evaluate the effect of the crop succession and the splitting of top-dressing N fertilization on the agronomic performance and economic viability of common bean crop. The experiment was conducted in southeastern Brazil for two agricultural seasons in an area under NTS, using a split-plot in randomized complete block design. The plots represented three cropping successions (maize in sole crop, maize intercropped with Urochloa ruziziensis and U. ruziziensis in sole crop) and the subplots composed of ten combinations of splitting of top-dressing N, at the stages V3, V4 and R5 of the common bean crop. In relation to the single application of the N dose of 90 kg ha−1, the common bean had higher response as a function of the N splitting schemes adopted, regardless of the previous cropping succession. The cropping successions evaluated did not interfere with the seed yield of common bean as subsequent crop, even at the beginning of the establishment of NTS. To obtain higher seed yield and economic viability, the N dose of 90 kg ha−1 indicated for the crop must be split and applied among the phenological stages V3, V4 and R5.
Anaemia status of preconception young married women in India
Authors: Biradar Rajeshwari A.
Published: July 2021

The early detection of anaemia is important for its subsequent control and incidence among women of childbearing age. This study aimed to assess the anaemia status of preconception young married women in India using National Family Health Survey-4 data collected in 2015–16. A total 65,238 sample preconception young married women were analysed using univariate, bivariate and multivariate techniques. A majority belonged to the Hindu religion (81.7%), lived in rural areas (64.5%) and had secondary level education (51.8%), and 41.7% had not yet given birth. The percentage suffering from anaemia was 51.3%. The prevalence of anaemia was higher among younger women (55.3%), those from Scheduled Tribes (59.0%), those living in rural areas (52.8%), the non-educated (55.9%), those in the poorest wealth quintile (56.9%), those from the East region (57.0%) and those with a low body mass index (BMI) (58.4%). The adjusted odds ratios indicated that, after controlling for significant background factors, Hindu, Scheduled Tribe, Scheduled Caste, East region, already having a child, too thin for their height and poorer and poorest wealth quintiles had higher odds of suffering from anaemia compared with the reference groups. The odds of suffering from anaemia decreased with age and education. The study showed a high burden of anaemia and associated risk factors among preconception young married women in India. The finding will inform decision-makers when planning interventions to decrease anaemia among women of childbearing age in India.
War, Coal, and Forced Labor: Assessing the Impact of Prisoner-of-War Employment on Coal Mine Productivity in World War I Germany
Authors: Jopp Tobias A.
Published: July 2021

This paper assesses the causal relationship between POW assignments and labor productivity for a vital sector of the German World War I economy, namely coal mining. Prisoners of war (POWs) provided significant labor. Combining data on all Ruhr mines with a treatment-effects approach, I find that POW employment alone accounted for 36 percent of the average POW-employing mine’s annual productivity decline over wartime. Estimates also suggest that the representative POW’s productivity averaged 32 percent of the representative regular miner’s productivity and that POWs’ contribution to wartime coal output amounted to 3.9 percent. Violence did not serve as a powerful work incentive.
From Material to Non-Material Needs? The Evolution of Mate Preferences through the Twentieth Century in France
Authors: Lippmann Quentin
Published: July 2021

This paper studies the evolution of mate preferences throughout the twentieth century in France. I digitized all the matrimonial ads published in France’s best-selling monthly magazine from 1928 to 1994. Using dictionary-based methods, I show that mate preferences were mostly stable during the Great Depression, WWII, and the ensuing economic boom. These preferences started transforming in the late 1960s when economic criteria were progressively replaced by personality criteria. The timing coincides with profound family and demographic changes in French society. These findings suggest that, in the search for a long-term partner, non-material needs have replaced material ones.
Theorizing about faith and faithfulness with Jonathan Kvanvig
Authors: McKaughan Daniel J. , Howard-Snyder Daniel
Published: July 2021

What are faith and faithfulness, and how are they related? We consider two views that express very different answers to these questions. On our view, faith and faithfulness are distinct and yet complement each other. Faith is resilient reliance and faithfulness is resilient reliability, both of which involve conative and/or affective elements. In contrast, while Jonathan Kvanvig also holds that faith involves conative and/or affective elements, he identifies faith with a disposition to act in service of an ideal in the face of difficulty. However, this view of faith leads to some puzzling claims about how faith relates to faithfulness. We evaluate several claims suggested by what Kvanvig says, arguing both that his view loses sight of the distinctness of faith and faithfulness and that the inferences he wants to draw from faithfulness or faithful behaviour to faith are unjustified. Instead, we aim to show how the insights he calls to our attention can be better accommodated and explained by a more comprehensive, unified theory of faith and faithfulness and their relations.
Continuity and catastrophic risk
Authors: Stefánsson H. Orri
Published: July 2021

Suppose that a decision-maker’s aim, under certainty, is to maximize some continuous value, such as lifetime income or continuous social welfare. Can such a decision-maker rationally satisfy what has been called ‘continuity for easy cases’ while at the same time satisfying what seems to be a widespread intuition against the full-blown continuity axiom of expected utility theory? In this note I argue that the answer is ‘no’: given transitivity and a weak trade-off principle, continuity for easy cases violates the anti-continuity intuition. I end the note by exploring an even weaker continuity condition that is consistent with the aforementioned intuition.
Random fractals and their intersection with winning sets
Authors: DAYAN YIFTACH
Published: July 2021

We show that fractal percolation sets in $\mathbb{R}^{d}$ almost surely intersect every hyperplane absolutely winning (HAW) set with full Hausdorff dimension. In particular, if $E\subset\mathbb{R}^{d}$ is a realisation of a fractal percolation process, then almost surely (conditioned on $E\neq\emptyset$), for every countable collection $\left(f_{i}\right)_{i\in\mathbb{N}}$ of $C^{1}$ diffeomorphisms of $\mathbb{R}^{d}$, $\dim_{H}\left(E\cap\left(\bigcap_{i\in\mathbb{N}}f_{i}\left(\text{BA}_{d}\right)\right)\right)=\dim_{H}\left(E\right)$, where $\text{BA}_{d}$ is the set of badly approximable vectors in $\mathbb{R}^{d}$. We show this by proving that E almost surely contains hyperplane diffuse subsets which are Ahlfors-regular with dimensions arbitrarily close to $\dim_{H}\left(E\right)$.

We achieve this by analysing Galton–Watson trees and showing that they almost surely contain appropriate subtrees whose projections to $\mathbb{R}^{d}$ yield the aforementioned subsets of E. This method allows us to obtain a more general result by projecting the Galton–Watson trees against any similarity IFS whose attractor is not contained in a single affine hyperplane. Thus our general result relates to a broader class of random fractals than fractal percolation.
How China's Wildlife Trade Legislation Permits Commercial Trade in Protected Wild Animal Species
Authors: White Aron
Published: July 2021

Wildlife trade policies in China and elsewhere have come under increased scrutiny following suggestions that the emergence of the coronavirus SARS-CoV-2 may have been linked to trade in wild animals. The breeding of and trade in most terrestrial wild animal species for consumption as food were prohibited in China in February 2020, but trade for non-food purposes such as ornamental items or traditional medicine continues to be covered by provisions in the Wildlife Protection Law (WPL). While a superficial reading of the WPL could lead to the conclusion that commercial trade in nationally protected species is generally prohibited, in practice key language is interpreted to permit commercial trade in the parts and derivatives of protected wild animal species, including those subject to the most stringent protection within China and internationally, such as leopards and pangolins.
Factors predicting long-term outcomes of percutaneous angioplasty and	stenting of the superior mesenteric artery for chronic mesenteric	ischemia
Authors: Awouters Joris , Jardinet Thomas , Hiele Martin , Laenen Annouschka , Dymarkowski Steven , Fourneau Inge , Maleux Geert
Published: July 2021

Summary: Background: To analyse the long-term outcomes of percutaneous angioplasty and stenting of the superior mesenteric artery (SMA) in the treatment of chronic mesenteric ischemia (CMI), and to assess predictive factors for a better clinical outcome. Patients and methods: Retrospective analysis of 76 consecutive patients, treated percutaneously for CMI between January 1999 and January 2018 and followed up until the end of 2018. Patients’ pre-, peri- and post-interventional clinical and radiological data were gathered from the institutional electronic medical records. The Kaplan Meier method with log rank test or the Cox model were used to analyse overall survival; the cumulative incidence function with Pepe and Mori test or the Fine and Grey model were used to analyse relapse-free survival, considering death as a competing event. Results: Seventy-six consecutive patients with a mean age of 72 years were included in the study. Catheter-angiography revealed an ostial or non-ostial >90% stenosis in n=23 (29.7%) and n=53 (69.7%) of included patients, respectively. Immediate clinical success was achieved in n=68 (89.5%), and procedural complications were observed in n=13 (17.1%) patients. Long-term follow-up revealed relapse of symptoms in n=21 (28.8%) patients, and overall survival estimates are 81.8%, 57.0% and 28.2% after two, five and ten years of follow-up, respectively. A trend towards longer relapse-free survival was found in the circumferential stenosis group (78.2% at five years) compared with the non-circumferential stenosis group (55.5%) (P=0.063). Conclusions: Angioplasty and stenting of the SMA for CMI is relatively safe and effective despite a substantial number of patients experiencing clinical relapse over time. Patients with focal, circumferential stenosis might have longer relapse-free survival than patients with non-circumferential stenosis.
Different Spatiotemporal Patterns in Global Human Population and Built‐Up Land
Authors: Gao Jing , O'Neill Brian
Published: July 2021

Population concentration and built‐up land expansion are two prominent features of contemporary urbanization. Existing literature on the population aspect of urbanization has mostly focused on national and regional aggregates, and literature on the land development aspect has often relied on spatial case studies of individual cities or their meta‐analyses. Using newly‐available data, here we conduct the first global‐coverage, spatial analysis of the relationship between (changes in) population and built‐up land at multiple spatial scales, and compare to existing common beliefs about urbanization based on individual city studies. We find that population and built‐up land show distinctly different spatial and temporal patterns (with a global correlation coefficient around 0.6). Contrary to common impressions, our results show that during recent decades, developed and developing regions across the world experienced comparable amounts of built‐up land expansion. While meta‐analyses have reported that built‐up land in urban areas expands globally on average twice as fast as population grows, our results show the global change rates of built‐up land and population are similar. Also, most global population, including what national statistics agencies call urban population, reside in areas with low land development levels (which are frequently less than 5% built up). These changes in perspective suggest that urbanization's potential large‐scale impacts may need to be re‐evaluated, and lead to best‐practice recommendations for urbanization modeling and analysis. Especially, the common practice in large‐scale earth system modeling of assuming demographically‐defined urban population resides in areas with medium to high built‐up land development levels should change.
What Controls the Probability Distribution of Local Wave Activity in the Midlatitudes?
Authors: Valva Claire , Nakamura Noboru
Published: July 2021

This paper examines probability distributions of local wave activity (LWA), a measure of the jet stream's meander, and factors that control them. The observed column‐mean LWA distributions exhibit significant seasonal, interhemispheric, and regional variations but are always positively skewed in the extratropics, and their tail often involves disruptions of the jet stream. A previously derived one‐dimensional (1D) traffic flow model driven by observed spectra of transient eddy forcing qualitatively reproduces the shape of the observed LWA distribution. It is shown that the skewed distribution emerges from nonlinearity in the zonal advection of LWA even though the eddy forcing is symmetrically distributed. A slower jet and stronger transient and stationary eddy forcings, when introduced independently, all broaden the LWA distribution and increase the probability of spontaneous jet disruption. A quasigeostrophic two‐layer model also simulates skewed LWA distributions in the upper layer. However, in the two‐layer model both transient eddy forcing and the jet speed increase with an increasing shear (meridional temperature gradient), and their opposing influence leaves the frequency of jet disruptions insensitive to the vertical shear. When the model's nonlinearity in the zonal flux of potential vorticity is artificially suppressed, it hinders wave‐flow interaction and virtually eliminates reversal of the upper‐layer zonal wind. The study underscores the importance of nonlinearity in the zonal transmission of Rossby waves to the frequency of jet disruptions and associated weather anomalies.
Klotzsche Receives 2020 Near-Surface Geophysics Early Career Achievement Award
Authors:   AGU
Published: July 2021

Anja Klotzsche received the inaugural Near-Surface Geophysics Early Career Achievement Award at AGU’s virtual Fall Meeting 2020. The award is given in recognition of “significant contributions to the field of near-surface geophysics by an early-career researcher.”
Remote-Controlled Ocean Drones Observe Atmospheric Cold Pools
Authors: Lee Jack
Published: July 2021

Novel uncrewed sailing vehicles measured properties of atmospheric cold pools in hard-to-reach regions of the central and eastern tropical Pacific Ocean.
Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation
Authors: Kim Kyung-Ran , Jeong Hyeon-Ju , Kim Yoonsub , Lee Seung Yeon , Kim Yujin , Kim Hyun-Ji , Lee Suk-Ho , Cho Hana , Kang Jong-Sun , Ho Won-Kyung
Published: July 2021

Calbindin, a major Ca2+ buffer in dentate granule cells (GCs), plays a critical role in shaping Ca2+ signals, yet how it regulates neuronal function remains largely unknown. Here, we found that calbindin knockout (CBKO) mice exhibited dentate GC hyperexcitability and impaired pattern separation, which co-occurred with reduced K+ current due to downregulated surface expression of Kv4.1. Relatedly, manipulation of calbindin expression in HT22 cells led to changes in CaMKII activation and the level of surface localization of Kv4.1 through phosphorylation at serine 555, confirming the mechanism underlying neuronal hyperexcitability in CBKO mice. We also discovered that Ca2+ buffering capacity was significantly reduced in the GCs of Tg2576 mice to the level of CBKO GCs, and this reduction was restored to normal levels by antioxidants, suggesting that calbindin is a target of oxidative stress. Our data suggest that the regulation of CaMKII signaling by Ca2+ buffering is crucial for neuronal excitability regulation.
Clinical laboratory tests and five-year incidence of major depressive disorder: a prospective cohort study of 433,890 participants from the UK Biobank
Authors: Wainberg Michael , Kloiber Stefan , Diniz Breno , McIntyre Roger S. , Felsky Daniel , Tripathy Shreejoy J.
Published: July 2021

Prevention of major depressive disorder (MDD) is a public health priority. Identifying biomarkers of underlying biological processes that contribute to MDD onset may help address this public health need. This prospective cohort study encompassed 383,131 white British participants from the UK Biobank with no prior history of MDD, with replication in 50,759 participants of other ancestries. Leveraging linked inpatient and primary care records, we computed adjusted odds ratios for 5-year MDD incidence among individuals with values below or above the 95% confidence interval (<2.5th or >97.5th percentile) on each of 57 laboratory measures. Sensitivity analyses were performed across multiple percentile thresholds and in comparison to established reference ranges. We found that indicators of liver dysfunction were associated with increased 5-year MDD incidence (even after correction for alcohol use and body mass index): elevated alanine aminotransferase (AOR = 1.35, 95% confidence interval [1.16, 1.58]), aspartate aminotransferase (AOR = 1.39 [1.19, 1.62]), and gamma glutamyltransferase (AOR = 1.52 [1.31, 1.76]) as well as low albumin (AOR = 1.28 [1.09, 1.50]). Similar observations were made with respect to endocrine dysregulation, specifically low insulin-like growth factor 1 (AOR = 1.34 [1.16, 1.55]), low testosterone among males (AOR = 1.60 [1.27, 2.00]), and elevated glycated hemoglobin (HbA1C; AOR = 1.23 [1.05, 1.43]). Markers of renal impairment (i.e. elevated cystatin C, phosphate, and urea) and indicators of anemia and macrocytosis (i.e. red blood cell enlargement) were also associated with MDD incidence. While some immune markers, like elevated white blood cell and neutrophil count, were associated with MDD (AOR = 1.23 [1.07, 1.42]), others, like elevated C-reactive protein, were not (AOR = 1.04 [0.89, 1.22]). The 30 significant associations validated as a group in the multi-ancestry replication cohort (Wilcoxon p = 0.0005), with a median AOR of 1.235. Importantly, all 30 significant associations with extreme laboratory test results were directionally consistent with an increased MDD risk. In sum, markers of liver and kidney dysfunction, growth hormone and testosterone deficiency, innate immunity, anemia, macrocytosis, and insulin resistance were associated with MDD incidence in a large community-based cohort. Our results support a contributory role of diverse biological processes to MDD onset.
A novel and effective approach to generate germline-like monoclonal antibodies by integration of phage and mammalian cell display platforms
Authors: Jin Yu-jia , Yu Diao , Tian Xiao-long , Li Hui-xian , Zhou Xiao-chao , Kong Yu , Zhang Wei , Zhang Lu , Lei Cheng , Yang Zhen-lin , Tu Chao , Wu Yan-ling , Ying Tian-lei
Published: July 2021

Phage display technology allows for rapid selection of antibodies from the large repertoire of human antibody fragments displayed on phages. However, antibody fragments should be converted to IgG for biological characterizations and affinity of antibodies obtained from phage display library is frequently not sufficient for efficient use in clinical settings. Here, we describe a new approach that combines phage and mammalian cell display, enabling simultaneous affinity screening of full-length IgG antibodies. Using this strategy, we successfully obtained a novel germline-like anti-TIM-3 monoclonal antibody named m101, which was revealed to be a potent anti-TIM-3 therapeutic monoclonal antibody via in vitro and in vivo experiments, indicating its effectiveness and power. Thus, this platform can help develop new monoclonal antibody therapeutics with high affinity and low immunogenicity.
Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice
Authors: Beaulac Holly J. , Gilels Felicia , Zhang Jingyuan , Jeoung Sarah , White Patricia M.
Published: July 2021

The prevalence of noise-induced hearing loss (NIHL) continues to increase, with limited therapies available for individuals with cochlear damage. We have previously established that the transcription factor FOXO3 is necessary to preserve outer hair cells (OHCs) and hearing thresholds up to two weeks following mild noise exposure in mice. The mechanisms by which FOXO3 preserves cochlear cells and function are unknown. In this study, we analyzed the immediate effects of mild noise exposure on wild-type, Foxo3 heterozygous (Foxo3+/−), and Foxo3 knock-out (Foxo3−/−) mice to better understand FOXO3’s role(s) in the mammalian cochlea. We used confocal and multiphoton microscopy to examine well-characterized components of noise-induced damage including calcium regulators, oxidative stress, necrosis, and caspase-dependent and caspase-independent apoptosis. Lower immunoreactivity of the calcium buffer Oncomodulin in Foxo3−/− OHCs correlated with cell loss beginning 4 h post-noise exposure. Using immunohistochemistry, we identified parthanatos as the cell death pathway for OHCs. Oxidative stress response pathways were not significantly altered in FOXO3’s absence. We used RNA sequencing to identify and RT-qPCR to confirm differentially expressed genes. We further investigated a gene downregulated in the unexposed Foxo3−/− mice that may contribute to OHC noise susceptibility. Glycerophosphodiester phosphodiesterase domain containing 3 (GDPD3), a possible endogenous source of lysophosphatidic acid (LPA), has not previously been described in the cochlea. As LPA reduces OHC loss after severe noise exposure, we treated noise-exposed Foxo3−/− mice with exogenous LPA. LPA treatment delayed immediate damage to OHCs but was insufficient to ultimately prevent their death or prevent hearing loss. These results suggest that FOXO3 acts prior to acoustic insult to maintain cochlear resilience, possibly through sustaining endogenous LPA levels.
Intestinal Klebsiella pneumoniae infection enhances susceptibility to epileptic seizure which can be reduced by microglia activation
Authors: Lin Peijia , Lin Aolei , Tao Kaiyan , Yang Min , Ye Qinglin , Chen Hongnian , Chen Yuanyuan , Ma Yuanlin , Lin Zijun , He Miaoqing , Wang Xuefeng , Tian Xin
Published: July 2021

Epilepsy is a common nervous system disease, and the existing theory does not fully clarify its pathogenesis. Recent research suggests that intestinal microbes may be involved in the development of epilepsy, but which microbe is involved remains unclear. We used 16s rRNA sequencing to identify the most relevant gut microbe. To determine the relationship between this microbe and epilepsy, we used an animal model. In addition, western blotting and immunofluorescence, as well as inhibitor studies, were used to evaluate and confirm the role of microglia in this process. In this study, we first report an increase in gut Klebsiella pneumoniae in patients with epilepsy. Subsequently, animal studies revealed that Klebsiella pneumoniae in the intestinal tract affects seizure susceptibility and activates microglial cells to release inflammatory factors. Furthermore, the inflammatory response of microglial cells plays a protective role in the seizure susceptibility caused by an increased abundance of Klebsiella pneumoniae. Our results suggest that gut disruption may be involved in seizure regulation and microglia protect the brain against seizure under this condition. These findings provide a new perspective for research on the pathogenesis and prevention of epilepsy.