bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Analysis of the Treatment Outcomes of Itopride and Acotiamide in Functional Dyspepsia: A Real-World Retrospective Study
Authors:   Senior consultant, Gastroenterologist, Apollo Clinic Hindmotor, Hooghly, Bhadrakali, West Bengal, India, Bandyopadhyay Sanjay Kumar , Shankar B Ravi ,   Director, Department of Medical Gastroenterology, Yashoda Hospitals, Secunderabad, Telangana, India, Goyal Omesh ,   Professor, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
Published: November 2024

Background: Functional dyspepsia (FD) is a prevalent gastric neuromuscular disorder affecting approximately 20% of the global population, with significant economic implications, particularly in India, where prevalence rates vary between 7.6% and 49%. Characterized by epigastric pain, early satiety, and postprandial fullness, FD lacks identifiable anatomical abnormalities, complicating treatment. Prokinetic agents like Itopride and Acotiamide are commonly used, but face variability in treatment. Objective: This study aimed to evaluate the effectiveness and safety of Itopride versus Acotiamide in managing FD symptoms in a real-world Indian context. Methods: This retrospective study analysed prospectively maintained data (from January to August 2024) across three sites in India. Seventy-nine patients (57 on Itopride and 22 on Acotiamide) were assessed for symptom improvement at 4 and 8-weeks post-treatment initiation, using the Patient Assessment of Upper Gastrointestinal Symptom Severity Index (PAGI-SYM). Symptom severity grades were compared between treatment groups using the Fischer exact or Chi-square test. Results: The mean age of FD patients was 45.59 years, with 46.8% male and demographic parameters were similar across both treatment groups. Itopride treatment significantly reduced symptom severity for epigastric pain, burning, early satiation, and postprandial fullness (p≤0.05) compared to the baseline, while Acotiamide showed non-significant improvements at both 4 and 8 weeks. Between treatment, comparison found fewer high symptom severity grades with Itopride than Acotiamide treatment (e.g. 1.75% vs. 13.64%, p=0.003, for epigastric pain, 8 weeks treatment). Also, after 8 weeks, 61.4% of Itopride patients reported symptom resolution, contrasted with 31.82% in the Acotiamide group. Adverse events were mild and infrequent in both groups, indicating comparable safety profiles. Conclusion: This study provides valuable real-world evidence supporting the use of Itopride as a preferred treatment option for FD in India. Further research is warranted to establish long-term efficacy and safety across diverse populations. Keywords: Functional Dyspepsia; Itopride; Acotiamide; Prokinetic Agents; Symptom Severity Grades
From teacher to learner centred approach: the case of Bulawayo urban schools
Authors: Mangwaya Emily , Mangwaya Ezron
Published: November 2024

The frequent changes in the education industry have led to many controversies. Among these controversies include one between the learner centred and teacher centred approaches to education. The argument is on whether learning approaches and processes should be tailored to the needs of students or whether students should act just like knowledge receptacles in a situation where teachers act as the sources of knowledge. This study explores how secondary school teachers can move from the teacher to the learner centred approach as they discharge their duties. Adopting an interpretivist paradigm and case study design teachers’ views on transitioning from teacher to learner centredness are explored using interviews, document analysis and focus group discussions. While strategies for such transitioning were suggested by teachers in this article, it appears that there is need for frequent capacitation sessions as a way of assisting secondary school teachers to address concerns they have in relation to learner centredness and student assessment procedures.
IoT-Based Smart Agricultural Monitoring Using WSN and Predictive Analytics with Artificial Intelligence (AI)
Authors:   Associate Professor, Department of Electrical and Electronics Engineering KIT-Kalaignarkarunanidhi Institute of Technology, Coimbatore, India, K. K. ,   Senior Manager, TVR Consulting Services Private Limited Gajularamaram, Medchal Malkangiri district, Hyderabad - 500055, Telegana, India,   Professor, Dept of ECE, Meenakshi Sundararajan Engineering College, Kodambakkam Chennai, India,   Artificial Intelligence and Machine Learning, Sagar Institute of Research  Technology, Bhopal, India, Kanth Tatiraju V. Rajani , Babiyola A. , Mishra Haritima
Published: November 2024

Smart agriculture leverages Internet of Things (IoT) technology to improve crop yield, resource efficiency, and environmental sustainability. This study presents an IoT-based smart agricultural monitoring system that integrates Wireless Sensor Networks (WSNs) with predictive analytics to monitor key environmental parameters, such as soil moisture, temperature, humidity, and light intensity, in real-time. The system utilizes WSNs to gather data from distributed sensor nodes and employs machine learning models for predictive analytics, enabling proactive decision-making for optimized irrigation, fertilization, and pest control. Experimental results demonstrate that the proposed system enhances resource usage by 40% and increases crop yield by 30% compared to traditional farming methods with Artificial Intelligence (AI). Additionally, the predictive analytics component achieves an accuracy of 92% in forecasting environmental conditions, aiding in timely interventions and minimizing crop stress. This IoT-based solution supports sustainable farming practices and offers scalability for various agricultural applications, including precision farming and greenhouse monitoring.
Design Change Management using BIM and Autodesk Construction Cloud
Authors:   Student of Building Information Modeling and Management Master Programme, Syrian Virtual University, Syria, Hiba Hiba ,   Lecturer in the Maters's Programme in Building Information Modeling and Management at the Syrian Virtual University, Damascus, Syria, saoud Lama
Published: November 2024

Efficient change order management is crucial in construction, particularly as project requirements evolve over time. In Syria's traditional construction process, lengthy gaps between planning, design, and execution significantly increase the likelihood of changes. This paper introduces a methodology that leverages Building Information Modeling (BIM) and cloud computing to enhance change management. A detailed case study of the Al-Eddekhar Housing project in Tartous was conducted, where Revit was employed for 3D modeling and Primavera for scheduling and cost estimation. Changes were meticulously analyzed using Revit's Model Compare tool, tracked through Primavera, and managed using Autodesk Construction Cloud for seamless document exchange and version control. The integration of BIM and cloud computing facilitates real-time collaboration between teams, significantly reducing errors, minimizing delays, and boosting overall project efficiency. The platform also preserves a historical record of project versions, enables visual comparisons of 3D models, and streamlines the approval process for change orders.
Adopting the HBIM system as a basis for preserving the architectural heritage in the city of Aleppo (AL-Matbakh al-Ajami building as a case study)
Authors:   Master student in Building Information Modeling and Management -Syrian Virtual University, Syria, Samah Samah ,   Cultural heritage rehabilitation Expert – Lecturer at Syrian Virtual University – ICOMOS Expert (International Council of Monuments and Sites), Syria, Asslan Hala
Published: November 2024

This study examines the role of Historic Building Information Modelling (HBIM) in preserving the architectural heritage of the Old City of Aleppo, focusing on a case study of the Al-Matbakh al-Ajami building. The study aims to provide an integrated framework for using HBIM for documenting and managing historical buildings. This is done through multiple stages and working according to the levels of detail by developing the 3D model from LOD200 to LOD500, which contributes to improving restoration and maintenance processes.
Analisis Zona Laterisasi Bawah Permukaan Menggunakan Metode Geolistrik (Resistivity)
Authors: Dullah Nurkhalis Mahmudah , Dzakir La Ode , Amir Muhamad Karnoha
Published: November 2024

Metode geolistrik resistivitas merupakan metode yang digunakan untuk mengidentifikasi resistivitas batuan ultramafik dibawah permukaan. Tujuan metode geolistrik resitivitas adalah untuk melihat kondisi endapan atau zona laterisasi nikel laterit dibawah permukaan. Berdasarkan hasil penelitian dapat disimpulkan bahwa lapisan atas dari zona laterisasi terdiri dari top soil dan batuan sedimen (batu lempung) yang dicitrakan dengan gradasi warna biru muda- biru tua. Pada beberapa titik pola upper resistivity yang tipis diatas lapisan batu lempung yang diinterpresikan sebagai topsoil. Zona limonit dicitrakan dengan warna ungu yang terdapat pada kedalaman 40 mdpl sampai dengan -20 mdpl dengan ketebalan lapisan ini adalah sekitar 3 meter. Lapisan berikutnya berupa lapisan saprolit yang dicitrakan dengan warna kuning dengan ketebalan hingga 13 meter dan pola endapan mengikuti bentukan pola endapan dari zona bedrock yang dicitrakan dengan warna merah.
Simulasi Metode Geolistirk Resistivity Dan IP Untuk Penentuan Konfigurasi Elektroda Pengukuran Yang Akurat Bijih Mangan Kabupaten Sukabumi Provinsi Jawa Barat
Authors: Hasrianto Hasrianto , Raivel Raivel , Noor Moh Khaidir , Hasan Haslinda , Imran Ali
Published: November 2024

Salah satu metode eksplorasi geofisika yang digunakan untuk mendeteksi keberadaan bijih mangan adalah metode geolistrik. Metode geolistrik resistivity dan chargeability IP merupakan metode aktif yang menginjeksikan arus ke bawah permukaan untuk mengetahui model litologi bawah permukaan. Tujuan dari penelitian ini adalah untuk menentukan nilai resistivity dan chargeability IP metode geolistrik hasil simulasi dan untuk pemilihan konfigurasi elektroda yang akurat dari 3 (tiga) konfigurasi elektroda geolistrik simulasi. Metode yang digunakan yaitu metode geolistrik resistivity dan chargeability IP, konfigurasi elektroda yang digunaka konfigurasi Wenner Alpha, Dipole – Dipole dan konfigurasi elektroda Wenner - Sclumberger. Hasil penelitian menunjukan rentang nilai resistivity dan chargeability bijih mangan hasil simulasi dari tiga konfigurasi elektroda yaitu 6.22 – 32.10 Ohm.m dan 3.52 – 36.93 msec, dikategorikan sebagai resistivity rendah dan chargeability rendah. Dari tiga konfigurasi elektroda yang digunakan pada hasil simulasi, konfigurasi elektroda Dipole – Dipole yang mendekati hasil model simulasi bijih mangan dan konfigurasi tersebut lebih akurat dibandingkan konfigurasi elektoda yang lain.
Estimasi Sumberdaya Andesit Menggunakan Metod Cross Section Pada Desa Toyomarto Kecamatan Singosari Kabupaten Malang Provinsi Jawa Timur
Authors: Jayaputra Harsalim Aimunandar , Amarullah Muhammad Romi , Pradani Diana Irmawati , Pratama Gindang R. , Lydianingtias Diah
Published: November 2024

Kegiatan eksplorasi pertambangan merupakan tahapan awal dalam menentukan suatu wilayah prospek atau tidak untuk ditambang dengan melakukan penelitian akan estimasi sumberdaya maka didapatkan hasil yaitu potensi serta klasifikasi sumberdaya pada suatu wilayah. Pada Desa Toyomarto, Kecamatan Singosari, Kabupaten Malang, Jawa Timur telah diidentifikasi akan adanya potensi sumberdaya andesit dengan melakukan analisis potensi andesit diatas permukaan dan dibawah permukaan. Penelitian ini diharapkan dapat mengetahui jumlah sumberdaya andesit dan juga mengetahui lapisan batuan yang terdapat dibawah permukaan pada lokasi penelitian. Teknik analisis potensi sumberdaya andesit permukaan dilakukan dengan pengamatan sebaran singkapan andesit serta literatur kajian geologi regional. Kemudian untuk analisis potensi sumberdaya andesit dibawah permukaan dilakukan dengan bantuan data survey geolistrik menggunakan metode Vertical Electrical Sounding (VES) dengan konfigurasi Schlumberger. Potensi sumberdaya andesit juga dilakukan dengan menaksir kuantitas sumberdaya andesit menggunakan metode Cross Section didapatkan hasil perhitungan volume andesit sebesar 1.743.938,19 m3 dan tonase andesit dengan densitas 2,65 gr/cm3 sebesar 4.621.435,7 ton.
Rancangan Desain Tambang Nikel Laterit Pada Blok D PT. Pernick Sultra Site Waturambaha Kecamatan Lasolo Kepulauan Kabupaten Konawe Utara Provinsi Sulawesi Tenggara
Authors: Ikhsan M. , Yatjong Isramyano , Dzakir La Ode
Published: November 2024

PT. Pernick Sultra merupakan perusahaan yang bergerak di bidang pertambangan mineral. Wilayah IUP
Operasi Produksi PT. Pernick Sultra berada di Desa Waturambaha, Kecamatan Lasolo Kepulauan Kabupaten
Konawe Utara, Provinsi Sulawesi Tenggara. Penelitian ini dilaksanakan di Blok D yang memiliki luas 5,9 Ha.
Tujuan dari penelitian ini adalah untuk mengetahui estimasi cadangan di blok D, berapa volume dan tonase
endapan nikel laterit dengan menggunakan metode Kriging. Data yang dibutuhkan dalam penelitian ini adalah data
assay, collar, geology, survey dan topografi lalu menggunakan software surpac 6.6.3 untuk mengestimasi
cadangan. Selain itu software surpac juga untuk membuat desain pit blok D dan layout desain tambang.
Dari data hasil estimasi cadangan nikel laterit pada blok D dengan metode Kriging menggunakan software
surpac dari jumlah data titik bor sebanyak 30 titik dengan spasi random dimana jarak spasi terkecil 28 m dan jarak
spasi terbesar 66 m dengan pola pemboran zigzag. Diketahui jumlah tonase adalah sebesar 306.000 ton dan
volume 204.000 m³, dengan kadar rata – rata Ni 2.02%. Dalam pembuatan desain pit ada beberapa parameter
yang perlu diperhatikan seperti ketentuan COG perusahaan sebesar 1.4%, rekomendasi geometri lereng dengan
tinggi jenjang 5 m, lebar jenjang 2 m dan kemiringan 50°. Dari hasil desain pit berdasarkan cadangan yang telah
didapatkan dapat dihasilkan luasan pit bukaan sebesar 5,9 Ha . Layout bertujuan untuk mengetahui letak sarana
dan prasarana tambang. Pada daerah penelitian meliputi desain pit, disposal area, jalan angkut dan stockpile.
Adapun jarak dari pit ke disposal sejauh 245 meter dan jarak pit ke stockpile sejauh 391 meter.
Mentir no plural: uma proposta de classificação das fake news
Authors: Silveira Fábio Alves
Published: November 2024

O fenômeno da desinformação na era das redes sociais tem na disseminação das notícias falsas um dos seus pilares. O objetivo deste artigo é identificar padrões na produção de notícias falsas divulgadas durante a pandemia de Covid-19 para justificar as políticas negacionistas adotadas pelo governo brasileiro. O corpus foi constituído por 142 matérias checadas pelas agências Lupa e Fato ou Fake entre maio e outubro de 2021. A pesquisa exploratória, de caráter quali-quantitativo, empregou análise de conteúdo e método dedutivo. Foram identificadas duas categorias de notícias falsas: invenção e adulteração; sendo esta última dividida em quatro subcategorias: distorção, descontextualização, fraude, falsa simetria. Ainda que 50% das notícias falsas tenham sido forjadas por processos primários de invenção, a análise identifica que a outra metade foi constituída por conteúdos distorcidos que indicam uma estrutura complexa de financiamento da produção.
Fotografia e fricções de imaginários sobre a Praia do Futuro
Authors: Macêdo Daniel , Machado Elian
Published: November 2024

Praia do Futuro é uma espacialidade que remonta projetos múltiplos, sobressaltando o comercializado pelo city marketing aos turistas; e os partilhados pela população que habita a capital cearense. Entendendo que estas perspectivas coexistem, confrontam-se e conferem potência diante da produção de imagens como expressão de imaginários, este trabalho se faz em ação de campo orientada em vínculos de proximidade e de afetividade durante os períodos de maio a julho de 2014, de 2016 e de 2019 a fim de refletir sobre as dinâmicas de inscrição com imagens – realizada por mim e por outros sujeitos que conosco praticavam o espaço – constituídas com as entramações ali possíveis. Para, assim, discutir a tessitura de imaginários a partir das práticas narrativas com fotografias que, em meio aos regimes de temporalidades, disputam rumos para a cidade.
O dia nacional da consciência negra e a reflexão sobre racismo estrutural na enfermagem brasileira
Authors: Silva Simone Albino da , Moreira Juliana Aparecida Pacheco
Published: November 2024

O Dia Nacional da Consciência Negra convoca a enfermagem a refletir sobre as políticas de redução da desigualdade social e racial no Brasil. Nas últimas décadas, políticas afirmativas, como o acesso democratizado ao ensino superior para negros, pardos, indígenas e egressos de escolas públicas, têm sido desenvolvidas, transformando a participação de negros nas universidades. No entanto, mesmo com o aumento de diplomados negros, desafios persistem em termos de visibilidade e prestígio. Dados preliminares mostram que a maioria dos enfermeiros no sul de Minas Gerais se identifica como branca, apesar de mais de 50% da enfermagem brasileira ser composta por negros, predominantemente em níveis técnicos. A baixa presença de enfermeiros negros em cargos superiores, influenciada por variáveis de raça, destaca o racismo institucional. É necessário promover discussões e pesquisas para combater o racismo estrutural e aumentar a representatividade negra nos postos de trabalho de nível superior na enfermagem.
Pengaruh Penerapan Model Inquiry Learning Berbantuan Modul Terhadap Hasil Belajar Siswa pada Mata Pelajaran IPS Kelas VII SMPN 12 Padang
Authors: Darmansyah Darmansyah , Zelhendri Zelhendri , Pratiwi Rahmi , Hidayatulah Serlin
Published: November 2024

Based on the results of observations at SMPN 12 Padang, a problem was found that most of the grade VII students in the Social Sciences (IPS) subject still did not reach the limit of the Learning Goal Achievement Criteria (KKTP) that had been set. This is because the teaching and learning process is still centered on teachers (teacher centred) and the use of models that are not suitable for learning activities. This study proves that the application of the Inquiry Learning learning model supported by learning modules significantly improves student learning outcomes in social studies subjects in grade VII of SMPN 12 Padang. This study uses a quasi-experimental method with a pretest-posttest control group design. The research sample was taken by purposive sampling by dividing students into two groups: an experimental group taught using the Inquiry Learning model and a control group taught by conventional methods. The main data collection technique is through learning outcome tests given before and after treatment. Data analysis was carried out using a t-test to compare the average post-test scores of the two groups. The results of the analysis showed a significant difference between the two groups, where the experimental group obtained a higher average score. This indicates that the Inquiry Learning model is effective in improving students' conceptual understanding of social studies subjects.
Speech Signal Splicing Detection system based on MFCC and DTW
Authors: Narla Venkata Lalitha , Suresh Gulivindala , K Singh Mahesh , M Vinod Kumar
Published: November 2024

One of the key forensics topics has been the detection of speech forgeries, mostly using real evidence in court. The transmission of digital speech recording data over several media exposes the data to the risk of being attacked or tampered with. Several people misuse the audio by altering that using editing software, such as Adobe, Audition CC, etc., which results in speech forgeries. So, to overcome these scenarios speech forgery detection method is deployed. A speech forgery detection method for splicing is implemented in this paper. Firstly, voiced segments are identified in the speech signal and calculated Mel Frequency Cepstral Coefficients (MFCC). These coefficients are considered as features and are stored in the database for the registered speakers. Similarly, features are calculated for each voiced segment of test signals and compared those features with the database by using dynamic time warping. This proposed method is tested on 225 original speech signals that are recorded in two different environments using two different microphones. By combining original recordings of two distinct speakers, a forged dataset of 4900 spliced speech signals is developed to test the efficacy of the developed method. An accuracy of 99.39% was attained and is superior to other existing methods.
Food and beverage service training in hospitality schools—An overview through the eyes of students, faculty, and industry professionals
Authors: Bhakat Ajoy , Bhardwaj Ranit
Published: November 2024

This study aims to evaluate and contrast the training that current food and beverage (F&B) service students received at their hospitality schools with the usefulness of such training and its effects on the hotel business. The study also aims to examine how the F&B service students’ acquired skills are perceived by industry professionals after the new graduates enter the job. Students majoring in the F&B service department of hotel management at the undergraduate level served as the study’s subjects. This article employs a survey approach in order to determine what and how hospitality schools could best educate F&B service students for success in the profession. The viewpoints of students, instructors from hospitality schools, and hotel managers are presented in this study. The findings showed that there are discrepancies in perceptions of the efficacy of the current training programs. Additionally, suggestions are sought to improve training programs. In order to assure success and sustainable growth, educators and hotels should focus on the essential competencies of the F&B service professionals. The report offers proof of the strengths and weaknesses of the F&B service education process at catering institutions. The results have significant ramifications for programs that teach F&B service as well as other hospitality-related subjects in schools.
PROCESSO DE REGULARIZAÇÃO E HABITE-SE DE IMÓVEL UNIFAMILIAR – ESTUDO DE CASO REALIZADO NO BAIRRO SÃO JOSÉ OPERÁRIO, EM MANAUS/AM
Authors: Abreu Bruno Matos de , Pinheiro Érika Cristina Nogueira Marques , Santos Karoline Socorro da Fonseca
Published: November 2024

A regularização e habite-se de imóveis atua como uma ferramenta para assegurar o uso adequado de ocupações, bem como a execução de obras e serviços de engenharia. As principais diretrizes perante ao tema estão sob as disposições da Lei Complementar n 003 e a Lei n 1.838, ambas datadas de 16 de janeiro de 2014, e demais legislações técnicas a serem explanadas no desenvolvimento deste artigo. Na região Norte, em especial, no estado do Amazonas, tal processo de regularização viabiliza a mudança de cenário em bairros mais isolados e municípios distantes, pois com a emissão da documentação os imóveis agregam valor, o que por consequência, atrai rotatividade econômica e provoca o avanço da infraestrutura local. Nesse contexto, o desenvolvimento desse estudo tem como objetivo descrever o processo executivo da regularização e habite-se de um imóvel unifamiliar de interesse social, localizado no bairro São José Operário, na cidade de Manaus/Amazonas. Com a análise dos resultados observou-se que o processo realizado ocorreu de maneira acertiva, com o cumprimento de cada etapa pertinente e com a atuação íntegra dos órgãos competentes.
A APLICABILIDADE DA NOVA LEI DE LICITAÇÃO NA REALIDADE BRASILEIRA: DESAFIOS E PERSPECTIVAS
Authors: Souza Junior Clébio Ribeiro de , Costa Lavínia Borges Neris , Iervese Pietro Davi Andrade
Published: November 2024

Através de uma revisão bibliográfica abrangente, foi possível identificar que a lei nº 14.133/2021 trouxe inovações e desafios para a gestão pública. A mencionada lei buscou modernizar e simplificar os procedimentos licitatórios, promovendo maior transparência, competitividade e eficiência. As novas regras introduzidas incluem a unificação de diversas legislações anteriores, a criação de novas modalidades de licitação, a diversificação dos critérios de julgamento, a ampliação do rol de punições, dentre outros aspectos. No entanto, a implementação da nova lei enfrenta desafios como a necessidade de capacitação dos agentes públicos, a resistência a mudanças e a complexidade de alguns dispositivos legais. Além disso, a pesquisa aponta para a importância de um acompanhamento contínuo e de ajustes para garantir a efetividade da legislação.
ASSISTÊNCIA FARMACÊUTICA EM DESASTRES
Authors: Machado Aline Monteiro , Gnatta Diego
Published: November 2024

Introdução: Este estudo explora a Assistência Farmacêutica (AF) no Brasil, em situações de desastres meteorológicos, enfatizando a importância de reduzir os impactos na saúde pública por meio do acesso e uso racional de medicamentos essenciais. Tais desastres frequentemente resultam em um aumento de doenças, demandando uma resposta rápida e eficiente do sistema de saúde. A AF realiza um papel importante na contenção de surtos de doenças e na manutenção da saúde das populações afetadas. Objetivo: Analisar desafios enfrentados, estratégias adotadas e as melhores práticas identificadas na literatura sobre a AF em desastres meteorológicos, bem como descrever ações realizadas durante as enchentes que ocorreram no Rio Grande do Sul, em maio de 2024. Metodologia: A pesquisa, baseada em uma busca na literatura e análise documental, até outubro de 2024, consistiu na revisão de publicações científicas, relatórios de organizações humanitárias e documentos oficiais relacionados à AF em desastres meteorológicos. A análise dos dados foi realizada de forma qualitativa (temática), destacando as principais ações, desafios e boas práticas encontradas na literatura. Resultados: Os resultados estão apresentados e discutidos por temas emergentes que incluíram a importância da assistência farmacêutica na saúde pública em situações de desastres; preparação e resposta em situações de desastres; ações durante em situações de desastres; as enchentes de 2024 no Rio Grande do Sul e recuperação pós-desastres. Os principais desafios para a assistência farmacêutica em desastres são a alta demanda por medicamentos, destruição de infraestruturas de saúde, interrupção de cadeias de suprimentos e a fragilidade na formação dos profissionais. Conclusão: Fortalecer a resistência dos sistemas de saúde em caso de calamidades requer uma abordagem integrada, que envolva planejamento contínuo, capacitação continuada de profissionais e criação de estoques de emergência. Dessa forma, os serviços farmacêuticos podem responder de maneira eficiente e sustentável às emergências, minimizando impactos na saúde das populações afetadas.
Практичні підходи до формування інноваційних стратегій розвитку підприємництва на глобальних ринках
Authors: Чорнодід І. C. , Василець Н. М. , Пекін А. Ю.
Published: November 2024

The article examines practical approaches to developing innovative strategies for entrepreneurship in global markets. The authors analyze the theoretical foundations of globalization, innovation, and entrepreneurship, explore current trends in managing enterprises in a global context, and identify the key challenges and opportunities businesses face. Special attention is given to the development of a typology of innovative strategies aimed at adapting enterprises to rapidly changing external conditions and enhancing their competitiveness. The study highlights that globalization drives economic integration, expands opportunities for businesses, but also increases competition and creates new risks. Innovative strategies based on technological, marketing, organizational, and social innovations enable enterprises to meet the demands of global markets. The article provides examples of successful companies, such as Tesla, IKEA, and Amazon, which demonstrate the effectiveness of innovation in ensuring sustainable development. The research methodology included analysis and synthesis, systematization, case studies, and content analysis. Based on the analysis of empirical data and theoretical foundations, the authors proposed a typology of innovative strategies focused on technological, marketing, organizational, and social aspects. The challenges and opportunities associated with the use of innovations in the global business environment, including digitalization risks, the need for adaptation to local conditions, and social responsibility challenges, are discussed. The article emphasizes the need for enterprises to be flexible, innovative, and sustainability-oriented to achieve leadership in international markets. Success in a globalized world requires a strategic approach to innovation management, consideration of local market features, and active use of digital technologies. The results outline key issues in developing strategies for successfully entering international markets, scaling businesses, and enhancing competitiveness.  Type of article: theoretical.
Chronotoxicity Studies in Pharmaceutical Science: A Comprehensive Review
Authors: Güdül Ülfet , Kordbacheh Hananeh , Sanajou Sonia , Şahin Gönül
Published: November 2024

Chronotoxicity evaluates the time-dependent toxicity of xenobiotics together with an individual’s circadian rhythm. Suprachiasmatic nuclei located in the hypothalamus regulate circadian rhythms in individuals. Circadian rhythms are important for human health, metabolic processes, inflammation, and various cancers. This comprehensive review aims to provide an overview of the literature on chronotoxicity, circadian pharmacokinetics, and chronoefficiency. Our literature search was conducted using databases including “Web of Science,” “PubMed,” and “Science Direct.” We used the keywords “circadian rhythm dysregulation,” “chronotoxicity of therapeutics,” “chronotoxicity,” and “time-dependent toxicity” for our literature search. Chronopharmacokinetics studies pharmacokinetic changes related to dosage time. Light plays an important role in circadian rhythm by stimulating ganglion cells. The stimulus is transferred to the suprachiasmatic nuclei and other parts of the brain that regulate the circadian rhythm. Evaluation of the risks and benefits of various therapeutic options requires detailed knowledge of the complex mechanisms that regulate circadian rhythms.
Determining The Assay Of New Formulation Low Dosage Naltrexone HCl Capsules with A RP-HPLC Method
Authors: Burgaz E. Vildan
Published: November 2024

Naltrexone hydrochloride (NLX HCl) is a medication primarily used in the management of alcohol and opioid dependence. NLX HCl is an opioid antagonist that blocks the effect of opioids by binding to opioid receptors in the brain without activating them. This study aims to determine the assay amount of new formulation low dosage NLX HCl capsules by High-Performance Liquid Chromatography (HPLC). HPLC method is very precise, specific, simple, accurate and sensitive method for assay determination of new formulation NLX HCl (3.0 mg and 4.5 mg). The chromatographic separation was achieved using Eclipse XDB-12 C18 (150 mm x 4.6 mm, 5 μm particle size) column using UV detection at 280 nm. The mobile phase consisted of a variable mixture of Solution A and Solution B with gradient, run at a flow rate of 1.0 mL/min. According to our research, NLX HCl has a retention time of 10.5 minutes. The linearity range was established between 1.1-3.40 mg/mL.
Görme Yetersizliği Olan Bir Çocuğun Okul Ortamındaki Durumu Üzerine Bir Durum Çalışması
Authors: Gülmez Haşem , Kardeş Servet
Published: November 2024

Amaç: Bu araştırma görme yetersizliği olan (az gören) bir çocuğun yetersizliğinden kaynaklanan güçlükler ve bu güçlüklerin bireyin gelişimi üzerindeki etkilerini incelemek amacıyla yapılmıştır.
Yöntem ve Araçlar: Araştırmada nitel araştırma yöntemlerinden durum çalışması kullanılmıştır. Durum çalışması desenlerinden ise bütüncül tek durum deseni kullanılmıştır. Araştırmada Van ilinin merkez bir ilçesinin bir köyünde bulunan 1. Sınıf öğrencisi olan az gören bir kız çocuğunun davranışları incelenmiştir. Bu çalışmayla görme yetersizliği olan bireylerin gelişimsel olarak ne durumda olduğu ve eğitim ortamındaki ihtiyaçları göz önüne serilmeye çalışılmıştır. Bu çalışmada görme yetersizliği olan bir bireyin okul içindeki davranışları gözlemlenmiş olup görme yetersizliği olan bireyin ailesi ve öğretmeni ile görüşme yapılmıştır. Eğitim ortamında gözlemlenen bireyin eğitim ortamında ne tür zorluklarla karşılaştığı öğretmenin ve ailenin nasıl bir yol izlediği incelenip raporlaştırılmıştır.
Sonuçlar: Araştırmada materyallerin boyutu, materyallerin zemin ile zıt renkli olması, materyallerin farklı duyu organlarına hitap etmesi az gören çocuğun eğitimi için oldukça önemli olduğu sonucuna ulaşılmıştır. Az gören birey görme yetersizliğinden dolayı arkadaşlarından daha yavaş hareket etmektedir. Sırf arkadaşlarından geri kalmamak için bir an önce yapayım kaygısı gütmekte ve bundan dolayı çoğu şeyi üstünkörü, özensiz bir şekilde yaptığı görülmektedir. Ayrıca görme yetersizliği olan bireyin arkadaşlarını sürekli memnun etme çabasının olduğu görülmüştür.
Enhancing Cyber Risk Reduction and the Role of the European Union
Authors: Saveleva Dovgal Larisa , Su Fei , Saalman Lora
Published: November 2024

Cyber risk reduction within and among China, Russia, the United States and the European Union has become increasingly important, while significantly more challenging. Despite their different threat landscapes, all four cyber actors face similar cyber risks and regulatory challenges, including on terminology, data transfer and trade flows, jurisdictional tensions and penalty enforcement. Building on previous SIPRI research, including a workshop with Chinese, Russian, US and European experts, this research policy paper explores the respective views on cyber risk reduction regulatory measures and recommendations for enhancement. It concludes with approaches for the EU to enhance its role on cyber risk reduction, including among member states and through collaborative engagement with China, Russia and the USA.
EFEKTIVITAS PENGGUNAAN BAHAN AJAR KETERAMPILAN MENULIS TEKS PROSEDUR BERBASIS E-FLIPBOOK PADA SISWA KELAS VII SMP NEGERI 1 PARUNGKUDA KABUPATEN SUKABUMI
Authors: Ridoillahy Girin , Sarimanah Eri , Nurjaman Aam , Mukhtar Ruyatul Hilal
Published: November 2024

The Effectiveness of Using E-Flipbook Based Teaching Materials for Writing Procedure Texts for Class VII Students of SMP Negeri 1 Parungkuda, Sukabumi Regency.
Abstract. The purpose of this study was to determine the procedural text writing skills of class VII students of SMP Negeri 1 Parungkuda, Sukabumi Regency and the obstacles experienced by class VII students of SMP Negeri 1 Parungkuda, Sukabumi Regency in improving procedural text writing skills by using e-flipbook based procedural text writing skills teaching materials. . The method used in this study is the experimental method, the data collection techniques used are tests, questionnaires, and observations. The population in this study were seventh grade students of SMP Negeri 1 Parungkuda, Sukabumi Regency. The sample of this research is class VII D as the experimental class and class VII F as the control class by using cluster random sampling technique. The first hypothesis is the effectiveness of using e-flipbook based procedural text writing skills in improving the ability to write procedural texts in seventh grade students of SMP Negeri 1 Parungkuda, Sukabumi Regency. this is evidenced by the obtaining of experimental class pretest data with an average value of 42.2 (low ability) in writing procedure text, while the experimental class posttest results in writing procedure text increased with an average value of 82.9 (able). The results of the calculation of the comparison of the mean of the experimental class and the control class using the t test formula, obtained the price data and db = 58. and obtained the price of and the price of . Thus, the value of t_count is greater than t_table or the price of because the value of< is 1,672,39. These results indicate that the use of procedural text writing skills based on e-flipbooks effectively improve procedural text writing skills in seventh grade students of SMP Negeri 1 Parungkuda, Sukabumi Regency.

Keywords: Writing skills, procedural text, e-flipbook based teaching materials.
Multimedia in Education: Readiness, Expertise and Multimedia Needs in Education
Authors: Linthaluek Siwaporn , Chanthra Rattanaporn , Suwannawong Naphatsanan , Siriwattananon Natt , Chunngam Bunthida , Satitpong Phuchit
Published: November 2024

This research aimed to explore the readiness, expertise, and multimedia needs in education. An online questionnaire was used to collect data. A total of 124 students from the Faculty of Industrial Education responded to the survey. The data showed that most students have notebooks and smart phones as important tools for creating multimedia. The results showed that students have expertise and multimedia needs in education. Overall, there was a median level of expertise and the highest level of needs in multimedia for learning. This research contributes to the ongoing dialogue on multimedia integration in education by providing insights into educators’ readiness, expertise, and multimedia needs. By understanding and addressing these factors, stakeholders can work towards harnessing the full potential of multimedia technology to enhance teaching and learning experiences in educational settings.
Hayat Bilgisi Dersinde Değerler Eğitimi Bağlamında Yapılan Araştırmalara Yönelik Bir Meta-Sentez Çalışması
Authors: Aydın Yıldıray
Published: November 2024

Bu araştırmanın amacı hayat bilgisi dersi değer eğitimi ile ilgili yapılmış olan araştırmaların nasıl olduğunu ortaya koymaktır. Bu nedenle araştırma meta-sentez yöntemi ile yürütülmüştür. Yöntem bağlamında dört farklı araştırma sorusu ve sekiz farklı dahil etme/ dışarıda tutma ölçütleri belirlenmiştir. Bu ölçütlere göre “Dergi Park Akademik”, “YÖK Ulusal Tez Merkezi” ve “Google Scholar” veri tabanları üzerinden hayat bilgisi dersinin değerler eğitimi boyutuna yönelik yapılmış olan 28 farklı araştırmaya ulaşılmış ve 24’ü meta-senteze dahil edilmiştir. Araştırma soruları bağlamında tematik veya içerik çözümleme yapılmıştır. Araştırmanın sentezleme süreci 14 Ocak 2024 -25 Haziran 2024 tarihleri arasında gerçekleştirilmiştir. Meta-sentez sonucunda 2018-2023 yılları arasında yapılmış olan hayat bilgisi dersi değer eğitimi konulu 24 farklı araştırmanın 18’inin doğrudan durum tespitine yönelik, altısının ise uygulama temelli olduğu belirlenmiştir. Uygulama temelli olan araştırmalarda hayat bilgisi dersi değer eğitiminde Uzman Mantosu, Hizmet Ederek Öğrenme, Etkinlik Temelli Öğrenme, Görsel Kültür Çalışmalarının, kullanılabileceği kanıtlanmıştır. Değer eğitimi için öncelikle değerlerin hayat bilgisi dersi öğretim programına, ders kitaplarına dengeli, sistematik bir yapı içerisinde yerleştirilmesi, özellikle ilkokul ders kitaplarında görsellerle, hikayelerle, sorularla değerlerin örtük veya açık bir şekilde yansıtılması gerektiği sonucu ortaya çıkmıştır. Ayrıca sınıf öğretmenlerinin değer eğitimi konusunda uygulamalı eğitimle beraber değer eğitimi konulu klavuz, etkinlik örneği, görsel, video vb materyale ihtiyacı olduğu belirlenmiştir.
Türkiye Yüzyılı Maarif Modeli’nin 21. Yüzyıl İnsan Profili Açısından Değerlendirilmesi
Authors: Yıldırım Yusuf , Çalışkan Alperen
Published: November 2024

Bu araştırmada Türkiye Yüzyılı Maarif Modeli’nin 21. yüzyıl insan profili açısından değerlendirilmesi amaçlanmıştır. Bu açıdan model sırasıyla; öğrenci profili, erdem-değer-eylem modeli, beceri eğitimi ve getirdiği yenilikler bakımından dört farklı başlıkta ele alınmıştır. Türkiye Yüzyılı Maarif Modeli’nde öğrenci profilinin açıkça ifade edildiği ve eğitim-öğretim sürecinin sonunda öğrencinin kazanması gereken yeterlilikler ve yetkinliklerin programın temel hareket noktasını oluşturduğu tespit edilmiştir. Model kapsamında değerler eğitimine yönelik bir model tasnifi yapıldığı ve bu modelde yer alan değerlere ilişkin göstergelerin bulunduğu saptanmıştır. Becerilerin ise kavramsal, sosyal-duygusal öğrenme ve alan becerileri şeklinde alt bileşenler ve süreç bileşenlerini içererek aktarıldığı görülmüştür. Türkiye Yüzyılı Maarif Modeli ile birlikte eğitim-öğretim sürecine birtakım yenilikler gelmiş ve yıllardır örtük olan birtakım eğitimsel faktörler modellenerek açıklanmıştır. Geliştirilen model sadece beceri temelli bir yapıda tasarlanmıştır. Dolayısıyla becerilere verilen önemin değerlere atfedilmediği için erdem-değer-eylem modelinin süreç temelli kurgulanmamasında eylem kısmının yetersiz kaldığı anlaşılmıştır. Bunun yanı sıra öğrenci profili başlığında girişimcilik gibi bir özelliğin doğrudan değil, alt bileşen olarak verilmesi; yeniliklere açık olmak gibi bir yeterlilikten bahsedilmemesi; kariyer planlaması yapma gibi önemli bir yetkinliğin yer almamış olması modelin noksanlıkları olarak ön plana çıkmıştır. Bu bakımdan bir sonraki model geliştirme süreçlerinde belirtilen eksikliklerin giderilmesine, sadece beceri ağırlıklı yapı yerine beceri ve değer temelli bir model geliştirilmesi önerilebilir.
Türkçe Öğretmeni Adaylarının Yapay Zekâya Yönelik Tutumlarının İncelenmesi
Authors: Sarıkaya Bünyamin , Kavan Nihat
Published: November 2024

Bilgi teknolojilerinin gelişmesi eğitime de yansımıştır. Bu teknolojilerin zirve noktalarından biri de yapay zekâdır. Eğitim dünyası da yapay zekâdan sıklıkla yararlanmaya başlamıştır. Buna binaen araştırmanın temel amacı, Türkçe öğretmeni adaylarının yapay zekâya yönelik tutumlarını incelemektir. Araştırmada, nicel araştırma yönteminin betimsel tarama modeli kullanılmıştır. Araştırmanın örneklemini bir devlet üniversitesinde öğrenimlerine devam eden 270 Türkçe öğretmeni adayı oluşturmuştur. Araştırmada verilerin toplanmasında Türkçeye uyarlama çalışması yapılan “Yapay Zekâya Yönelik Genel Tutum Ölçeği” kullanılmıştır. Ölçek, iki boyut ve yirmi maddeden oluşmaktadır. Veriler, çevrim içi ortamda toplanıp parametrik analizlere tabi tutulmuştur. Araştırma sonucunda Türkçe öğretmeni adaylarının yapay zekâya ilişkin tutumlarının “orta düzeyde” olduğu belirlenmiştir. Çalışma sonucunda Türkçe öğretmeni adaylarının yapay zekâya ilişkin tutumlarının; sınıf düzeyi, yapay zekâyı kullanma durumu, yapay zekâ hakkında genel bilgi sahibi olma değişkenleri açısından anlamlı farklılık gösterdiği belirlenmiştir. Çalışmada, Türkçe eğitiminde yapay zekâya yönelik çalışmaların arttırılması, yapay zekâya becerisine yönelik uygulama temelli ders ve çalışmaların sayıca arttırılması, yapay zekâya yönelik kaygı, tutum ve etik konularının işlenmesi gerektiği, eğitimde yapay zekâdan en iyi şekilde nasıl yararlanılabileceğine dair nitelikli çalışmaların yapılması gerektiği ve yapay zekâ eğitimi konusunda eğitimin bütün paydaşlarına seminer, konferans ve hizmet içi eğitim gibi etkinliklerin verilmesinin yararlı olacağı önerilmiştir.
Service Quality dan Marketing Mic dalam Menunjang Keberhasilan UMKM Makanan di Kecamatan Coblong, Kota Bandung
Authors: Annisa Azzahra
Published: November 2024

The growth of MSMEs in Indonesia, particularly in the culinary sector, holds substantial potential for bolstering the national economy, with Coblong District in Bandung City emerging as a rapidly developing hub; however, despite the fierce competition, the success of culinary MSMEs in this area is influenced not only by product quality but also by factors such as service quality and the marketing mix, prompting this study to investigate their contribution to the success of culinary MSMEs in Coblong District, using a quantitative approach where data from 36 MSMEs were collected via questionnaires, and although the results of multiple linear regression analysis reveal that neither service quality nor the marketing mix have a significant impact on the success of these MSMEs, both factors still play an essential role in supporting customer satisfaction and achieving business goals.
Pengaruh Pelatihan dan Pengembangan Karyawan terhadap Produktivitas Kerja Karyawan Pada CV Firjhi Karya Group
Authors: Lia Indah Safitri
Published: November 2024

This research aims to determine the effect of training and development on employee work productivity at CV FIRJHI KARYA GROUP East Jakarta, both partially and simultaneously. This research uses a quantitative approach with associative methods. Data collection techniques use observation, questionnaires and literature study. The number of samples in this study was 30 respondents and the data was processed using the SPSS.21 application. Results Research shows that training has a partial positive effect and significant to employee work productivity, as evidenced by the T Test obtained from The calculated t value is 4.544 > greater than the t table 2.051 and the significance value is 0.000 < smaller than 0.05. And partial development has a positive effect significant impact on employee work productivity, as evidenced by the T Test results obtained from The calculated t value is 6.582 > greater than the t table 2.051 and the significance value is 0.001 < smaller than 0.05. Then Training and Development simultaneously have a positive and significant effect on employee work productivity. This is proven based on the F Test results obtained from the calculated f value of 103.510 > greater than f table 3.34 and a significance value of 0.000 < smaller than 0.05.
Penerapan Pemasaran Digital Sebagai Media Promosi
Authors: Sussanti Sussanti  , Veronica Krisni Damayanti  , Mulyadi Amin
Published: November 2024

Digital marketing as a promotional strategy emerged as a response to developments in information technology. The use of digital marketing is not only limited to new companies or start-ups, but is also applied by companies that have been around for a long time. PT. XYZ, which functions as a motor vehicle distributor and retailer, is also required to adopt digital marketing even though it already has a strong brand from its parent company. In this research, which uses a case study of PT. XYZ, data obtained through observation and interviews. The research results show that PT. XYZ uses three media in implementing digital marketing, namely websites, social media and applications. Of the three media, social media such as Instagram and Facebook show the best results, because both are used to provide information and build engagement with consumers.
Analisis Penggunaan E-Commerce Terhadap Bisnis Usaha Mikro, Kecil, dan Menengah
Authors: Veronica Krisni Damayanti  , Mulyadi Amin  , Deden Sunandar
Published: November 2024

Currently, e-commerce is increasingly in demand by various business groups, both large and small scale. This is due to the ease of promotion through online media or digital marketing, which makes it easier for business people to reach consumers to introduce or sell their products. This research aims to understand the impact of using e-commerce for MSME business actors. Data was collected through semi-structured interviews with MSME players who have used e-commerce to market their products. Data from these interviews were analyzed using the *thematic analysis* method which aims to identify patterns and find themes based on the data collected (Braun and Clarke, 2006). The research results show several categories related to the use of e-commerce by MSMEs, including individual abilities, reasons for not switching to other e-commerce platforms, as well as obstacles experienced such as infrastructure, technology, promotions, and unpleasant experiences faced by MSMEs when using e-commerce. commerce.