bluuebunny/crossref_metadata_2025 huggingface dataset:
NEMATERIJALNO MOTIVISANJE ZAPOSLENIH
Authors: Jekić Cviko
Published: June 2016

Ljudski potencijali zajedno sa finansijskim sredstvima i fizičkom imovinom daju kvalitet koji treba da se prepozna i napravi način aktivira. Ljudi se razlikuju po svojim znanjima, sposobnostima, vještinama i motivima, što u osnovi određujeoblik njihovog ponašanja i uspješnost u ostvarivanju ciljeva organizacije. Stoga, menadžment ljudskih potencijala i ljudskipotencijali su specifična i složena tema kojoj mora da se pristupi na temeljan i specifičan način.Produktivnost rada, ostvarene performanse i posvećenost organizaciji u direktnoj su vezi sa motivacijom zaposlenih.Dosadašnji koncepti motivacijskih sistema, motivacijskih tehnika i strategija su dali određene rezultate. Zaposleni su sveobrazovaniji i očekuju više, pa je potrebno razvijati i uvoditi nove motivacione tehnike koje će svojom razrađenošću isvestranošću dovesti do visoke motivisanosti i zadovoljstva zaposlenih, a time i do kvalitetnijeg poslovanja.Cilj ovog rada je da ukaže na značaj i područja nematerijalne motivacije zaposlenih. Za većinu zaposlenih svakim danompostaju sve bitnije, tzv. potrebe višeg reda, odnosno razvoj i potvrđivanje vlastitih sposobnosti i mogućnost autonomije,uvažavanja, određenog statusa i drugo. Stoga, istražiti i utvrditi nematerijalna područja motivacije, postaju aktivnosti odizuzetne važnosti za menadžment organizacije.
PRINCIPI I METODOLOGIJA EFIKASNE ORGANIZACIJE SKLADIŠNOG PROSTORA
Authors: Tešić Dejan , Košutić Neda
Published: June 2016

Skladišta imaju nekoliko bitnih funkcija, ali dvije najvažnije su privremeni smještaj roba, do njihovog daljeg korišćenjau proizvodnji ili distribuciji, te očuvanje kvaliteta roba. Kako bi se ova dva cilja ostvarila neophodno je robu organizovatiunutar skladišta u zone, te odrediti kapacitet i broj zona, veličinu skladišta, broj dokova, stepen popunjenosti skladišta idrugo. Efikasna organizacija skladišnog prostora je složen problem, koji zahtijeva donošenje mnogih povezanih odluka,koje mogu da budu strateške, taktičke i operativne, u zavisnosti od vremenskog perioda na koji se donose. Da biorganizacija skladišnog prostora bila zasnovana na što pouzdanijim informacijama, koriste se različite kvantitativnemetode. Ove metode imaju za cilj olakšati i usmjeriti menadžment u upravljanju skladištem. Cilj ovog rada jestedefinisanje osnovnih principa i metoda koje pomažu menadžmentu preduzeća u efikasnom upravljanju prostorom iprocesima u skladištu.
FER VRIJEDNOST U BANKARSKOM SEKTORU
Authors: Hasanović Mirsada
Published: June 2016

U savremenom računovodstvu se sve češće spominje pojam fer vrijednosti kao jedan od novijih pristupa priznavanja imjerenja imovine i obaveza. U ovom radu ćemo se bliže upoznati sa pojmom fer vrijednosti, MRS 39 i MRS 13 kojebanke koriste prilikom priznavanja i vrednovanja finansijske imovine i obaveza. Akcenat ovog rada je na fer vrijednostiu bankama uz korištenje podataka koje pružaju banke na području BiH u svojim finansijskim izvještajima, zatim fervrijednosti u bankama u vrijeme finansijske krize.
Clathrin modulates vesicle scission, but not invagination shape, in yeast endocytosis
Authors: Kukulski Wanda , Picco Andrea , Specht Tanja , Briggs John AG , Kaksonen Marko
Published: June 2016

In a previous paper (Picco et al., 2015), the dynamic architecture of the protein machinery during clathrin-mediated endocytosis was visualized using a new live imaging and particle tracking method. Here, by combining this approach with correlative light and electron microscopy, we address the role of clathrin in this process. During endocytosis, clathrin forms a cage-like coat around the membrane and associated protein components. There is growing evidence that clathrin does not determine the membrane morphology of the invagination but rather modulates the progression of endocytosis. We investigate how the deletion of clathrin heavy chain impairs the dynamics and the morphology of the endocytic membrane in budding yeast. Our results show that clathrin is not required for elongating or shaping the endocytic membrane invagination. Instead, we find that clathrin contributes to the regularity of vesicle scission and thereby to controlling vesicle size.
Serotonin transporter gene (5-HTT) polymorphism and major depressive disorder in patients in Bogotá, Colombia
Authors: Pérez-Olmos Isabel , Bustamante Delia , Ibáñez-Pinilla Milcíades
Published: June 2016

Introducción. El polimorfismo 5-HTT se ha asociado con el trastorno de depresión mayor, aunque el planteamiento ha generado controversia.
Objetivo. Determinar la asociación del polimorfismo 5-HTT con la depresión mayor en Bogotá, Colombia.
Materiales y métodos. Se hizo un estudio de casos y controles pareado por sexo y edad (±5 años), con una razón de uno a uno (68:68). El trastorno de depresión mayor se diagnosticó con el cuestionario Mini-International Neuropsychiatric Interview, y, el polimorfismo 5-HTT, mediante reacción en cadena de la polimerasa (PCR).
Resultados. Las mujeres predominaron entre los participantes (82,4 %). El alelo corto (short, S) predominó en los casos comparados con los controles (S: 72,1 % Vs. 63,2; L (long): 27,9 % Vs. 36,8 %), y el genotipo SL fue más frecuente en los casos (SL: 45,6 % Vs. 36,8 %; LL: 27,9 % Vs. 36,8 %; SS: 26,5 % Vs. 26,5 %), aunque no significativamente. Hubo diferencias significativas en menores de 37 años, con predominio del alelo S en los casos (p=0,0384; odds ratio - OR=2,75; IC95%: 0,88-8,64). El análisis multivariado ajustado por trastornos concomitantes de ansiedad mostró una asociación significativa de la depresión mayor con el genotipo SL (p=0,049; OR=3,20; IC95% 1,003-10,233); el alelo S estuvo cerca de la significación estadística (p=0,063; OR=2,94; IC95% 0,94-9,13), y fue estadísticamente significativo en los casos de menores de 37 años (p=0,026; OR=10,79; IC95% 1,32-80,36).
Conclusiones. El genotipo SL se asoció con el trastorno de depresión mayor en pacientes de todas las edades. El alelo S se asoció significativamente con el trastorno de depresión mayor en pacientes menores de 37 años al ajustar por trastornos concomitantes de ansiedad.
Adaptive changes in chlorophyll content and photosynthetic features to low light in Physocarpus amurensis Maxim and Physocarpus opulifolius “Diabolo”
Authors: Zhang Huihui , Zhong Haixiu , Wang JIfeng , Sui Xin , Xu Nan
Published: June 2016

The present study aims to investigate the differences in leaf pigment content and the photosynthetic characteristics under natural and low light intensities between the Chinese nativePhysocarpus amurensis Maximand the importedPhysocarpus opulifolius“Diabolo” from North America. We aim to discuss the responses and the adaptive mechanism of these two cultivars ofPhysocarpusto a low light environment. The results show that the specific leaf area (SLA) and the chlorophyll content were significantly increased in the leaves of bothPhysocarpuscultivars in response to a low light intensity, and the SLA and chlorophyll content were higher in the leaves of low light-treatedP. opulifolius“Diabolo” compared with the leaves of low light-treatedP. amurensis Maxim. Moreover, the content of anthocyanin was markedly reduced in the leaves ofP. opulifolius“Diabolo” under low light intensity, which allowed for a greater capacity of photon capture under the low light condition. Under natural light, the photosynthetic carbon assimilation capacity was greater in the leaves ofP. amurensis Maximcompared with the leaves ofP. opulifolius“Diabolo” that were rich with anthocyanin. However, in response to low light, AQY,Pmax, LCP and LSP decreased to a lesser extent in the leaves ofP. opulifolius“Diabolo” compared with the leaves ofP. amurensis Maxim. These results suggest thatP. opulifolius“Diabolo” exhibits a greater ability in adaption to low light, and it is probably related to the relatively higher chlorophyll content and the smaller SLA in the leaves ofP. opulifolius“Diabolo.” In addition, the low light intensity resulted in a reduced photochemical activity of photosystem (PS) II in the leaves of bothPhysocarpus, as evidenced by increased values of the relative variable fluorescence at point J and point I on the OJIP curve. This result suggests that the electron acceptor in PS II was the major responsive site to the low light stress in the leaves of bothPhysocarpuscultivars, and that the low light intensity significantly inhibited electron transfer on the acceptor side of PS II and reduced the activity of the oxygen-evolving complex (OEC) in the leaves of bothPhysocarpuscultivars. The PS II function inP. opulifolius“Diabolo” was higher than that inP. amurensis Maximin response to low light. Under low light, the composition of photosynthetic pigments was altered in the leaves ofP. opulifolius“Diabolo” in order to maintain a relatively high activity of primary photochemical reactions, and this is the basis of the greater photosynthetic carbon assimilation capacity and one of the main reasons for the better shade-tolerance inP. opulifolius“Diabolo.”
Local avian density influences risk of mortality from window strikes
Authors: Sabo Ann M. , Hagemeyer Natasha D.G. , Lahey Ally S. , Walters Eric L.
Published: June 2016

Up to a billion birds die per year in North America as a result of striking windows. Both transparent and reflective glass panes are a cause for concern, misleading birds by either acting as invisible, impenetrable barriers to desired resources, or reflecting those resources over a large surface area. A high number of window strikes occur during migration, but little is known about the factors of susceptibility, or whether particular avian taxa are more vulnerable than others. We report on a study of window strikes and mist-netting data at the Virginia Zoological Park (Norfolk, Virginia, USA), conducted in the autumn of 2013 and 2014. We focused on three factors likely to contribute to an individual’s predisposition to collide with windows: (i) taxonomic classification, (ii) age, and (iii) migrant vs. resident status. Thrushes, dominated by the partial migrant American Robin (Turdus migratorius), were significantly less likely to strike glass than be sampled in mist nets (χ2= 9.21, p = 0.002), while wood-warblers (Parulidae) were more likely to strike than expected (χ2= 13.55, p < 0.001). The proportion of juveniles striking windows (45.4%) was not significantly different (χ2= 0.05, p = 0.827) than the population of juvenile birds naturally occurring at the zoo (48.8%). Migrants, however, were significantly more susceptible to window strikes than residents (χ2= 6.35, p = 0.012). Our results suggest that resident birds are able to learn to avoid and thus reduce their likelihood of striking windows; this intrinsic risk factor may help explain the apparent susceptibility of certain taxa to window strikes.
Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr−/− mice
Authors: Krishack Paulette A. , Sontag Timothy J. , Getz Godfrey S. , Reardon Catherine A.
Published: June 2016

We previously showed that feeding a Western‐type diet (WTD) to Ldlr−/− mice lacking serum amyloid A (SAA) (Saa−/−Ldlr−/− mice), the level of total blood monocytes was higher than in Ldlr−/− mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage‐dendritic cell progenitor (MDP) cells were found in WTD‐fed Saa−/−Ldlr−/− mice compared to Ldlr−/− mice and lower levels of GMP cells and CMP cells in Ldlr−/− mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr−/− mice.
Forcing of the overturning circulation across a circumpolar channel by internal wave breaking
Authors: Broadbridge Maria B. , Naveira Garabato Alberto C. , Nurser A. J. George
Published: June 2016

The hypothesis that the impingement of mesoscale eddy flows on small‐scale topography regulates diapycnal mixing and meridional overturning across the deep Southern Ocean is assessed in an idealized model. The model simulates an eddying circumpolar current coupled to a double‐celled meridional overturning with properties broadly resembling those of the Southern Ocean circulation and represents lee wave‐induced diapycnal mixing using an online formulation grounded on wave radiation theory. The diapycnal mixing generated by the simulated eddy field is found to play a major role in sustaining the lower overturning cell in the model, and to underpin a significant sensitivity of this cell to wind forcing. The vertical structure of lower overturning is set by mesoscale eddies, which propagate the effects of near‐bottom diapycnal mixing by displacing isopycnals vertically.
Long‐term assessment of Aqua MODIS radiance observation using comparisons with AIRS and IASI
Authors: Veglio Paolo , Tobin David C. , Dutcher Steve , Quinn Greg , Moeller Christopher C.
Published: June 2016

This paper presents a detailed comparison between Atmospheric Infrared Sounder (AIRS) and Moderate Resolution Imaging Spectroradiometer (MODIS) measurements over the period 2003–2013 and also between MODIS and Infrared Atmospheric Sounding Interferometer (IASI) for the years 2007–2014. For this study AIRS and IASI high spectral resolution data are degraded to MODIS broadband spectral resolution and MODIS fields of view are averaged within the AIRS and IASI footprints. Using spatially uniform scenes, the brightness temperature differences (ΔBT) between MODIS and AIRS are analyzed as a function of scene temperature, scan angle, and solar zenith angle. In general, the measurements of the two sensors are in good agreement (ΔBT less than ±0.2 K) with little or no dependence on the scene temperature. A small dependence is found for the scan angle, where ΔBT varies off nadir up to about ±0.4 K; dependence on the solar zenith angle is also observed, with ΔBT varying up to ±0.5 K. Finally, the variation of ΔBT over time is stable with BT trending less than 0.02 K/yr, with exception of ΔBT for MODIS bands 33 and 35 in the 2011–2013 timeframe. This behavior, which is also identified in MODIS/IASI comparisons, correlates to adjustments in that timeframe of the MODIS nonlinear calibration coefficients.
Elevated aerosol layers and their radiative impact over Kanpur during monsoon onset period
Authors: Sarangi Chandan , Tripathi S. N. , Mishra A. K. , Goel A. , Welton E. J.
Published: June 2016

Accurate information about aerosol vertical distribution is needed to reduce uncertainties in aerosol radiative forcing and its effect on atmospheric dynamics. The present study deals with synergistic analyses of aerosol vertical distribution and aerosol optical depth (AOD) with meteorological variables using multisatellite and ground‐based remote sensors over Kanpur in central Indo‐Gangetic Plain (IGP). Micro‐Pulse Lidar Network‐derived aerosol vertical extinction (σ) profiles are analyzed to quantify the interannual and daytime variations during monsoon onset period (May–June) for 2009–2011. The mean aerosol profile is broadly categorized into two layers viz., a surface layer (SL) extending up to 1.5 km (where σ decreased exponentially with height) and an elevated aerosol layer (EAL) extending between 1.5 and 5.5 km. The increase in total columnar aerosol loading is associated with relatively higher increase in contribution from EAL loading than that from SL. The mean contributions of EALs are about 60%, 51%, and 50% to total columnar AOD during 2009, 2010, and 2011, respectively. We observe distinct parabolic EALs during early morning and late evening but uniformly mixed EALs during midday. The interannual and daytime variations of EALs are mainly influenced by long‐range transport and convective capacity of the local emissions, respectively. Radiative flux analysis shows that clear‐sky incoming solar radiation at surface is reduced with increase in AOD, which indicates significant cooling at surface. Collocated analysis of atmospheric temperature and aerosol loading reveals that increase in AOD not only resulted in surface dimming but also reduced the temperature (∼2–3°C) of lower troposphere (below 3 km altitude). Radiative transfer simulations indicate that the reduction of incoming solar radiation at surface is mainly due to increased absorption by EALs (with increase in total AOD). The observed cooling in lower troposphere in high aerosol loading scenario could be understood as a dynamical feedback of EAL‐induced stratification of lower troposphere. Further, the observed radiative effect of EALs increases the stability of the lower troposphere, which could modulate the large‐scale atmospheric dynamics during monsoon onset period. These findings encourage follow‐up studies on the implication of EALs to the Indian summer monsoon dynamics using numerical models.
Microfluidic observation of the onset of reactive‐infitration instability in an analog fracture
Authors: Osselin F. , Kondratiuk P. , Budek A. , Cybulski O. , Garstecki P. , Szymczak P.
Published: June 2016

Reactive‐infiltration instability plays an important role in many geophysical problems yet theoretical models have rarely been validated experimentally. We study the dissolution of an analog fracture in a simple microfluidic setup, with a gypsum block inserted in between two polycarbonate plates. By changing the flow rate and the distance between the plates, we are able to scan a relatively wide range of Péclet and Damkhöhler numbers, characterizing the relative magnitude of advection, diffusion, and reaction in the system. We quantify the characteristic initial wavelengths of the perturbed fronts during the onset of instability. The results agree well with theoretical predictions based on linear stability analysis, thus experimentally validating current reactive‐infiltration instability theory and opening new opportunities for experimental assessment of mineral reactivity.
Influence of the Reinforcement Distribution and Interface on the Electronic Transport Properties of MWCNT‐Reinforced Metal Matrix Composites
Authors: Suarez Sebastián , Souza Nicolás , Lasserre Federico , Mücklich Frank
Published: June 2016

The transition toward an electricity‐driven world is testing electrical contact materials to their limits. Specifically, new alternatives are needed where composites that sacrificed conductivity in exchange for reduced weldability and higher heat dissipation sufficed. Carbon nanotubes (CNT) have the potential to close the gap as ideal fillers due to their outstanding intrinsic properties, pushing the application limits further. However, the reported electrical conductivity measurements show no clear tendency. In the present study, the authors attempt to shed some light on this matter by focusing on the causes behind those results. It is observed that the addition of 1 wt% CNT improves the conductivity of nickel, followed by a drop for higher concentrations, measured by four‐point probe testing. Six nanotube orientation models describing different CNT arrangements are contrasted to the experimental data. Corrected values for nickel and CNT resistivities effectively place that of the composites close to the models, providing indications of a preferential orientation. It is concluded that, in contrast to what is widely reported, the main contributing factors to the resistivity are inter‐tube coupling, porosity, and interfacial scattering, whereas clustering marginally influences the behavior.
Understanding the Structural Evolution and Redox Mechanism of a NaFeO2–NaCoO2 Solid Solution for Sodium‐Ion Batteries
Authors: Kubota Kei , Asari Takuya , Yoshida Hiroaki , Yaabuuchi Naoaki , Shiiba Hiromasa , Nakayama Masanobu , Komaba Shinichi
Published: June 2016

Na‐ion batteries have become promising candidates for large‐scale energy‐storage systems because of the abundant Na resources and they have attracted considerable academic interest because of their unique behavior, such as their electrochemical activity for the Fe3+/Fe4+ redox couple. The high‐rate performance derived from the low Lewis‐acidity of the Na+ ions is another advantage of Na‐ion batteries and has been demonstrated in NaFe1/2Co1/2O2 solutions. Here, a solid solution of NaFeO2‐NaCoO2 is synthesized and the mechanisms behind their excellent electrochemical performance are studied in comparison to those of their respective end‐members. The combined analysis of operando X‐ray diffraction, ex situ X‐ray absorption spectroscopy, and density functional theory (DFT) calculations for Na1–

x
Fe1/2Co1/2O2 reveals that the O3‐type phase transforms into a P3‐type phase coupled with Na+/vacancy ordering, which has not been observed in O3‐type NaFeO2. The substitution of Co for Fe stabilizes the P3‐type phase formed by sodium extraction and could suppress the irreversible structural change that is usually observed in O3‐type NaFeO2, resulting in a better cycle retention and higher rate performance. Although no ordering of the transition metal ions is seen in the neutron diffraction experiments, as supported by Monte‐Carlo simulations, the formation of a superlattice originating from the Na+/vacancy ordering is found by synchrotron X‐ray diffraction for Na0.5Fe1/2Co1/2O2, which may involve a potential step in the charge/discharge profiles.
Ein einfacher Zugang zu funktionalen Mustern auf Cellulosepapier durch Kombination von Laserdruck und materialspezifischer Peptidadsorption
Authors: Große Steffi , Wilke Patrick , Börner Hans G.
Published: June 2016

Mittels Phagen‐Display wurden Peptide identifiziert, die materialspezifische Adsorption zeigen und effektiv zwischen Cellulose als Hauptbestandteil von Papier und dem Toner eines mit einem handelsüblichen Laserdrucker gedruckten Musters unterscheiden können. Diese genetisch selektierten 12mer‐Peptide können selektiv entweder nicht bedruckte Cellulose oder gedruckte Tonerstrukturen beschichten. Weiterhin wird eine chemische Ligation mit Triazolindion genutzt, um z. B. Farbstoffe und funktionale Peptide selektiv auf einer Oberflächenbeschichtung zu befestigen. Diese Methode bietet einen einfachen Zugang zur Funktionalisierung von Mustern auf papierbasierten Materialien, wodurch neue Wege zur Realisierung kostengünstiger diagnostischer oder biomedizinischer Geräte aufgezeigt werden können.
Study of gas–liquid mixing in stirred vessel using electrical resistance tomography
Authors: Sher Farooq , Sajid Zaman , Tokay Begum , Khzouz Martin , Sadiq Hamad
Published: June 2016

This study presents a full operation and optimization of a mixing unit; an innovative approach is developed to address the behaviour of gas–liquid mixing by using electrical resistance tomography. The validity of the method is investigated by developing the tomographic images using different numbers of baffles in a mixing unit. This technique provided clear visual evidence of better mixing that took place inside the gas−liquid system and the effect of a different number of baffles on mixing characteristics. For optimum gas flow rate (m3/s) and power input (kW), the oxygen absorption rate in water was measured. Dynamic gassing‐out method was applied for five different gas flow rates and four different power inputs to find out mass transfer coefficient (KLa). The rest of the experiments with one up to four baffles were carried out at these optimum values of power input (2.0 kW) and gas flow rate (8.5 × 10−4 m3/s). The experimental results and tomography visualizations showed that the gas−liquid mixing with standard baffling provided near the optimal process performance and good mechanical stability, as higher mass transfer rates were obtained using a greater number of baffles. The addition of single baffle had a striking effect on mixing efficiency, and additions of further baffles significantly decrease mixing time. The energy required for complete mixing was remarkably reduced in the case of four baffles as compared with without any baffle. The process economics study showed that the increased cost of baffle installation accounts for less cost of energy input for agitation. The process economics have also revealed that the optimum numbers of baffles are four in the present mixing unit, and the use of an optimum number of baffles reduced the energy input cost by 54%. © 2016 Curtin University of Technology and John Wiley & Sons, Ltd.
Solvent and relative humidity effect on highly ordered polystyrene honeycomb patterns analyzed by Voronoi tesselation
Authors: Ruiz‐Rubio Leire , Azpitarte Itxasne , García‐Huete Nuria , Laza José Manuel , Vilas José Luis , León Luis M.
Published: June 2016

Highly ordered honeycomb‐patterned polystyrene surfaces are efficiently prepared by static breath figure method. The structured arrays can be obtained by casting a dilute solution polymer on glass substrates under various conditions. Tetrahydrofuran and chloroform are used as solvent to form cavities of several micrometers. The analysis of the surfaces indicates nonlinear relation between concentration and pore size in this system. Voronoi tessellations of the polystyrene surfaces at different relative humidity (RH) are achieved, and each conformational entropy determined. Optimum parameters of concentration and RH are obtained for both solvents. Analysis of hole size distribution and conformational entropy demonstrates the high order of the films obtained. This is a promising method for the fabrication of homogeneous and highly porous films from polystyrene. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44004.
Determination of reactivity ratios for the copolymerization of poly(acrylic acid‐co‐itaconic acid)
Authors: Cummings Shidan , Zhang Yujie , Kazemi Niousha , Penlidis Alexander , Dubé Marc A.
Published: June 2016

Monomer reactivity ratios are important parameters used in copolymerization kinetics to predict the rate of polymerization, copolymer composition and monomer sequence length, and by extension, molecular weight and distribution of the final product. Batch aqueous solution copolymerizations of acrylic acid (AA) and itaconic acid (IA) are performed at various feed compositions. Polymerizations are categorized into low (<11 wt %) conversion and higher (< 30 wt %) conversion data sets for analysis. Due to the limited solubility of IA in the reaction mixture, the feed composition of IA in all polymerizations is constrained to lower than 25 mol %. Conversion is determined by gravimetric methods, and copolymer composition via 1H‐NMR spectroscopy. All data are analyzed using the error‐in‐variables model (EVM) method. Two analyses are used, one with the EVM approach and another with a novel Direct Numerical Integration (DNI) coupled with the EVM method. The DNI/EVM approach yields values of rAA = 0.36 and rIA = 1.62 for the reactivity ratios. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44014.
Anatomical Mapping and Density of Merkel Cells in Skin and Mucosae of the Dog
Authors: Ramírez Gustavo A. , Rodríguez Francisco , Quesada Óscar , Herráez Pedro , Fernández Antonio , Espinosa‐de‐los‐Monteros Antonio
Published: June 2016

Merkel cells (MCs) are specialized cutaneous receptor cells involved with tactile sense. Although the distribution of MCs has been extensively studied in humans and rodents, their precise distribution and density throughout skin in the dog has not previously been determined. Knowledge of their distribution could facilitate understanding of their functions. By using of immunohistochemistry, density, and anatomical mapping of the MCs population in the dog skin was determined. Assessment of the MCs innervation was also achieved. Different patterns were noted in epidermis, hair follicles, or mucosa, including variable‐sized clusters, linear or horse‐shaped arrangements, and scattered and individualized cells. MCs revealed great variations in density and distribution over the body surface, with the highest numbers in oral mucosa and facial skin. There was no correlation of MCs density with age, sex, type of breed, coat type or pigmentation. Between 41 and 65% of MCs in hairy and glabrous skin and 8–18% of MCs in oral mucosa were in intimate contact with intraepithelial axon terminals. These findings indicate that canine MCs are numerous in sensory receptive areas and may be associated with the tactile sense in the dog. The present article enhances the knowledge of the skin structure in this species. Anat Rec, 299:1157–1164, 2016. © 2016 Wiley Periodicals, Inc.
Inverse probability weighting estimation of the volume under the ROC surface in the presence of verification bias
Authors: Zhang Ying , Alonzo Todd A. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: June 2016

In diagnostic medicine, the volume under the receiver operating characteristic (ROC) surface (VUS) is a commonly used index to quantify the ability of a continuous diagnostic test to discriminate between three disease states. In practice, verification of the true disease status may be performed only for a subset of subjects under study since the verification procedure is invasive, risky, or expensive. The selection for disease examination might depend on the results of the diagnostic test and other clinical characteristics of the patients, which in turn can cause bias in estimates of the VUS. This bias is referred to as verification bias. Existing verification bias correction in three‐way ROC analysis focuses on ordinal tests. We propose verification bias‐correction methods to construct ROC surface and estimate the VUS for a continuous diagnostic test, based on inverse probability weighting. By applying U‐statistics theory, we develop asymptotic properties for the estimator. A Jackknife estimator of variance is also derived. Extensive simulation studies are performed to evaluate the performance of the new estimators in terms of bias correction and variance. The proposed methods are used to assess the ability of a biomarker to accurately identify stages of Alzheimer's disease.
RRM1 *151A>T, RRM1 ‐756T>C, and RRM1 ‐585T>Gis associated with increased susceptibility of lung cancer in Chinese patients
Authors: Xu Xiao‐Ling , Zheng Ji , Mao Wei‐Min , Ling Zhi‐Qiang
Published: June 2016

Ribonucleotide reductase M1 (RRM1) is a crucial gene in DNA repair. Recent studies have shown that RRM1 expression can be a powerful predictor of survival or chemotherapy sensitivity in patients presenting with carcinomas who are treated with adjuvant gemcitabine‐based chemotherapy including lung cancer. However, the relationship between the single nucleotide polymorphisms (SNP) of RRM1 and the susceptibility of lung cancer to chemotherapy has not been well addressed. We detected six tag SNPs of RRM1 genotypes in a cohort of 1007 patients with primary lung cancer and 1007 age‐ and sex‐matched population controls using SNaPshot detection technology. Logistic regression, odds ratios (OR), and 95% confidence intervals were calculated to estimate lung cancer risk associated with SNP genotypes and haplotypes, after adjusting for case–control matching factors. Compared with the T/T and A/T genotype of RRM1 *151A>T, the A/A genotype had an increased risk for overall lung cancer (adjusted OR, 1.33). Additionally, the T/T+T/C genotypes of RRM1 ‐756T>C were risk factors that increased the susceptibility to lung cancer (adjusted OR 1.54, as compared with the C/C genotype). While the T/T+G/T genotypes of RRM1 ‐585T>G behaved as protective factors to increase the susceptibility to lung cancer (adjusted OR 0.44, as compared with the C/C genotype). In summary, this is the first study to systematically identify the relationship between the polymorphisms of RRM1 and individual susceptibility to lung cancer. It is anticipated that the RRM1 *151A>T, RRM1 ‐756T>C, and RRM1 ‐585T>G polymorphisms will improve the predictive prognosis of lung cancer sensitivity.
TACC2 (transforming acidic coiled‐coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation
Authors: Onodera Yoshiaki , Takagi Kiyoshi , Miki Yasuhiro , Takayama Ken‐ichi , Shibahara Yukiko , Watanabe Mika , Ishida Takanori , Inoue Satoshi , Sasano Hironobu , Suzuki Takashi
Published: June 2016

Transforming acidic coiled‐coil protein 2 (TACC2) belongs to TACC family proteins and involved in a variety of cellular processes through interactions with some molecules involved in centrosomes/microtubules dynamics. Mounting evidence suggests that TACCs is implicated in the progression of some human malignancies, but significance of TACC2 protein in breast carcinoma is still unknown. Therefore, in this study, we examined the clinical significance of TACC2 in breast carcinoma and biological functions by immunohistochemistry and in vitro experiments. Immunohistochemistry for TACC2 was performed in 154 cases of invasive ductal carcinoma. MCF‐7 and MDA‐MB‐453 breast carcinoma cell lines were transfected with small interfering RNA (siRNA) for TACC2, and subsequently, cell proliferation, 5‐Bromo‐2′‐deoxyuridine (BrdU), and invasion assays were performed. TACC2 immunoreactivity was detected in 78 out of 154 (51%) breast carcinoma tissues, and it was significantly associated with Ki‐67 LI. The immunohistochemical TACC2 status was significantly associated with increased incidence of recurrence and breast cancer‐specific death of the patients, and multivariate analyses demonstrated TACC2 status as an independent prognostic factor for both disease‐free and breast cancer‐specific survival. Subsequent in vitro experiments showed that TACC2 significantly increased the proliferation activity of MCF‐7 and MDA‐MB‐453. These results suggest that TACC2 plays an important role in the cell proliferation of breast carcinoma and therefore immunohistochemical TACC2 status is a candidate of worse prognostic factor in breast cancer cases.
Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70‐interacting protein in postmenopausal breast cancer
Authors: Kurozumi Sasagu , Yamaguchi Yuri , Hayashi Shin‐ichi , Hiyoshi Hiromi , Suda Tetsuji , Gohno Tatsuyuki , Matsumoto Hiroshi , Takei Hiroyuki , Horiguchi Jun , Takeyoshi Izumi , Oyama Tetsunari , Kurosumi Masafumi
Published: June 2016

The carboxyl terminus of the Hsc70‐interacting protein (CHIP) is considered to induce the ubiquitination and degradation of several oncogenic proteins, and play a role in the inhibition of tumor progression and invasion under experimental conditions. However, the impact of CHIP expression on the prognosis of breast cancer patients has not yet been established. In this study, using an immunohistochemical method, 272 patients with invasive breast cancer were assessed for the expression of CHIP (graded scores 0‐3) and the statuses of biomarkers, such as estrogen receptor (ER), progesterone receptor (PgR), and HER2. The relationships between the statuses of CHIP and biomarkers as well as clinical features were also evaluated, and that between the expression of CHIP and patient prognosis was analyzed. We revealed that the strong expression of CHIP correlated with positive ER (P < 0.001), positive PgR (P < 0.001), and negative HER2 (P = 0.02). In postmenopausal patients, relapse‐free survival (RFS) was significantly better in the high CHIP group than in the low CHIP group (P = 0.042). In addition, RFS and cancer‐specific survival (CSS) were significantly better in patients with ER‐positive/CHIP score 3 tumors than in those with ER‐negative/CHIP score 0 tumors (RFS: P = 0.038, CSS: P = 0.0098). The methylation status of CHIP gene promoter did not always account for the down‐regulation of its expression. In conclusion, the overexpression of CHIP is a potent prognostic factor of a good prognosis in ER‐positive breast cancer patients in the postmenopausal phase.
Sandwich Packings: State of the Art
Authors: Flechsig Steve , Yildirim Ömer , Kenig Eugeny Y.
Published: June 2016

Capacity and efficiency of packed columns can be significantly improved by the application of sandwich packings. An element of such packings consists of two alternating layers of industrially available standard packings with different specific surface areas. Sandwich packings are commonly used for operating conditions between the flooding points of both layers, with a heterogeneous flow pattern established along a sandwich packing element. There are some similarities between this flow pattern and those in conventional structured packings as well as in trays. Under certain conditions, this can be used in a beneficial way. However, the application of this integrated packing type is hindered by a lack of reliable design methods. In the present article, the results of recent activities are summarized.
Effects of the Framework and Mesoporosity on the Catalytic Activity of Hierarchical Zeolite Catalysts in Benzyl Alcohol Conversion
Authors: Li Chao , Cho Hong Je , Wang Zhuopeng , Gou Jinsheng , Ren Yanqun , Xi Hongxia , Fan Wei
Published: June 2016

The catalytic performance of three‐dimensionally ordered mesoporous imprinted (3DOm‐i) zeolite catalysts with different frameworks (3DOm‐i MFI, 3DOm‐i BEA, and 3DOm‐i LTA) were investigated by the liquid‐phase catalytic conversion of benzyl alcohol in mesitylene and compared to that of other microporous and mesoporous catalysts with a high external surface area, which included MCM‐22, 300 nm MFI, ITQ‐2, and Al‐MCM‐41. The mesoporosity in MFI and BEA zeolites can effectively enhance the catalytic performance of the zeolite catalysts for benzyl alcohol self‐etherification catalyzed by both the acid sites on the external and internal surface and the alkylation of mesitylene with benzyl alcohol catalyzed exclusively by the acid sites on the external surface. For 3DOm‐i LTA, MCM‐22, and Al‐MCM‐41, only the acid sites on the external surface can be utilized in the catalytic reactions. A distinct difference in the product selectivity was also observed for the microporous and mesoporous catalysts.
New Prospects toward the Synthesis of Difluoromethylated Phosphate Mimics
Authors: Ivanova Maria V. , Bayle Alexandre , Besset Tatiana , Pannecoucke Xavier , Poisson Thomas
Published: June 2016

The difluoromethyl phosphonate motif plays a crucial role in the development of bioactive molecules as it is considered as a phosphate bioisoster. Since 2010, a renewal of interest to enlarge the panel of reactions to access these difluoromethylated phosphonate‐containing molecules has been witnessed. This Concept article charts the recent progress that has been made.
ChemInform Abstract: Crystal Structure of Ba9La2W4O24 and Sr9Gd2W4O24: A New B‐Site Vacancy Ordered 4 x 4 x 4 Cubic Perovskite.
Authors: IJdo D. J. W. , Fu W. T. , Akerboom S.
Published: June 2016

The crystal structure of the title compounds (obtained by solid state reactions) are determined by powder XRD.
ChemInform Abstract: New Family of Materials with Negative Coefficients of Thermal Expansion: The Effect of MgO, CoO, MnO, NiO, or CuO on the Phase Stability and Thermal Expansion of Solid Solution Phases Derived from BaZn2Si2O7.
Authors: Thieme Christian , Waurischk Tina , Heitmann Stephan , Ruessel Christian
Published: June 2016

Replacement of Zn in Sr0.5Ba0.5Zn2Si2O7 by Mg and Co (0.1—0.7), Mn (0.1—0.5), Ni (0.1—0.3), and Cu (0.1, 0.2) is performed by solid state reactions of metal oxides or carbonates (1100—1300 °C, 30—50 h) with intermediate grinding steps.
ChemInform Abstract: GeAs: Highly Anisotropic van der Waals Thermoelectric Material.
Authors: Lee Kathleen , Kamali Saeed , Ericsson Tore , Bellard Maverick , Kovnir Kirill
Published: June 2016

GeAs and Sn‐doped GeAs are prepared from the elements (1373 K, 4—5 d) and characterized by powder XRD, SEM, 119Sn Moessbauer spectroscopy, transport measurements, and TB‐LMTO‐ASA calculations.
ChemInform Abstract: Hydrate Networks under Mechanical Stress — A Case Study for Co3(PO4)2·8H2O.
Authors: Bach Sven , Visnow Eduard , Panthoefer Martin , Gorelik Tatiana , Buzanich Ana Guilherme , Gurlo Aleksander , Kolb Ute , Emmerling Franziska , Lind Cora , Tremel Wolfgang
Published: June 2016

The mechanochemically (ball milling) induced loss of bound H2O in Co3(PO4)2·8H2O is investigated together with an associated phase transition and its kinetics by powder synchrotron XRD and quantitative IR spectroscopy.
ChemInform Abstract: New Series of Triple Molybdates AgA3R(MoO4)5 (A: Mg, R: Cr, Fe; A: Mn, R: Al, Cr, Fe, Sc, In) with Framework Structures and Mobile Silver Ion Sublattices.
Authors: Kotova Irina Yu. , Solodovnikov Sergey F. , Solodovnikova Zoya A. , Belov Dmitry A. , Stefanovich Sergey Yu. , Savina Aleksandra A. , Khaikina Elena G.
Published: June 2016

The title compounds of the triclinic NaMg3In(MoO4)5 type are prepared by solid state reaction of stoichiometric mixtures of the appropriate simple molybdates (873—1023 K).
ChemInform Abstract: The New Zintl Phases Eu21Cd4Sb18 and Eu21Mn4Sb18.
Authors: Wang Yi , Darone Gregory M. , Bobev Svilen
Published: June 2016

Crystals of the new title compounds are prepared by reaction of the elements in a molten Pb flux (alumina crucible, 1273 K, 24 h).
ChemInform Abstract: Flux Growth and Magnetic Properties of Rare Earth Cobalt Germanide, RE6Co5Ge1+xAl3‐x (RE: Pr, Nd; x ≈ 0.8).
Authors: Zhou Sixuan , Latturner Susan E.
Published: June 2016

The intermetallic compounds Ln6Co5Ge1.80Al2.20 (Ln: Pr, Nd) are prepared by reactions of Ge and Al in a reactive Ln/Co flux (alumina crucible, 950 °C, 12 h, annealing at 650 °C for 84 h).
ChemInform Abstract: Synthesis, Structural Characterization, and Catalytic Activity of Indenyl Tris(N‐pyrrolyl)phosphine Complexes of Ruthenium.
Authors: Stark Matthew J. , Shaw Michael J. , Rath Nigam P. , Bauer Eike B.
Published: June 2016

The title Ru‐complexes are catalytically active in the etherification of propargylic alcohols and in a tandem isomerization‐condensation sequence to yield xanthenones.
ChemInform Abstract: Preparation of Enantiomerically Pure Perfluorobutanesulfinamide and Its Application to the Asymmetric Synthesis of α‐Amino Acids.
Authors: Wangweerawong Apiwat , Hummel Joshua R. , Bergman Robert G. , Ellman Jonathan A.
Published: June 2016

Perfluorobutanesulfinamide (IV) is obtained in two steps and converted to imino ester (VI) which is used in the Rh/Ag‐catalyzed asymmetric C‐H addition to arenes bearing an ortho‐directing group to provide arylglycine derivatives.
ChemInform Abstract: An Asymmetric Vinylogous Michael Cascade of Silyl Glyoximide, Vinyl Grignard, and Nitroalkenes via Long Range Stereoinduction.
Authors: Boyce Gregory R. , Johnson Jeffrey S.
Published: June 2016

An optimized synthesis of the glyoximide is developed which is used for a completely regio‐ and highly diastereoselective three‐component coupling with nitrostyrenes and vinylmagnesium bromide to give compounds (VII).
ChemInform Abstract: Copper Catalyzed Coupling of Protecting Group Free and Sterically Hindered 2‐Bromobenzyl Tertiary Alcohols with Phenols and Anilines: Facile Synthesis of Xanthenes and Dihydroacridines.
Authors: Mahendar Lodi , Satyanarayana Gedu
Published: June 2016

The developed two‐step protocol requires only a single column purification technique.
ChemInform Abstract: A New Microwave‐Assisted Thionation‐Heterocyclization Process Leading to Benzo[c]thiophene‐1(3H)‐thione and 1H‐Isothiochromene‐1‐thione Derivatives.
Authors: Giofre Salvatore V. , Romeo Roberto , Mancuso Raffaella , Cicero Nicola , Corriero Nicola , Chiacchio Ugo , Romeo Giovanni , Gabriele Bartolo
Published: June 2016

The title compounds are prepared by a tandem thionation/S‐cyclization sequence starting from various alkynylbenzoic acids.
ChemInform Abstract: Hydride Reduction by a Sodium Hydride—Iodide Composite.
Authors: Too Pei Chui , Chan Guo Hao , Tnay Ya Lin , Hirao Hajime , Chiba Shunsuke
Published: June 2016

Reduction of nitriles, amides, and imines is achieved using NaH in the presence of LiI or NaI.
ChemInform Abstract: Stereoselective Synthesis of Iodofluoroalkenes by Iodofluorination of Alkynes Using IF5‐Pyridine‐HF.
Authors: Ukigai Hitoshi , Hara Shoji
Published: June 2016

The iodofluorination of alkynes is carried out using IF5‐pyridine‐HF and hydroquinone.
ChemInform Abstract: Organocatalytic Enantioselective Mukaiyama—Mannich Reaction of Fluorinated Enol Silyl Ethers and Cyclic N‐Sulfonyl Ketimines.
Authors: Yu Jin‐Sheng , Zhou Jian
Published: June 2016

In the presence of a quinine‐based bifunctional urea catalyst, cyclic N‐sulfonyl ketimines react with fluorinated enol silyl ethers to afford benzosultam based α‐amino acid derivatives possessing a fluoroalkyl group in high to excellent yields and stereoselectivities.
ChemInform Abstract: Copper‐Catalyzed Borylative Coupling of Vinylazaarenes and N‐Boc Imines.
Authors: Smith Joshua J. , Best Daniel , Lam Hon Wai
Published: June 2016

Azaarene‐containing, Boc‐protected aminoalcohols are prepared by three‐component coupling of vinylazaarenes, dipinacolyl hypodiborate, and N‐Boc imines followed by oxidation of initially formed boronates.
ChemInform Abstract: NaHCO3‐Catalyzed Highly Regiospecific Aminobromination of β,β‐Dicyanostyrene Derivatives with 1,3‐Dibromo‐5,5‐dimethylhydantoin (DBDMH).
Authors: Chen Zhanguo , Xia Wei , Liu De'e , Liu Yali , Du Manfei , Cao Chenxi
Published: June 2016

The aminobromination affords vicinal haloamino products with high regioselectivities at room temperature under aerobic conditions.
ChemInform Abstract: Pd(II)‐Catalyzed β‐C—H Arylation of O‐Methyl Ketoximes with Iodoarenes.
Authors: Mu Yucheng , Tan Xiaodong , Zhang Yemin , Jing Xiaobi , Shi Zhuangzhi
Published: June 2016

This protocol provides a powerful tool for late stage functionalization of complex molecules.
ChemInform Abstract: Bifunctional Broensted Base Catalyzes Direct Asymmetric Aldol Reaction of α‐Keto Amides.
Authors: Echave Haizea , Lopez Rosa , Palomo Claudio
Published: June 2016

This is the first direct catalytic asymmetric cross‐aldol reaction of α‐keto amides with aldehydes using a bifunctional catalyst.
ChemInform Abstract: Nickel‐Catalyzed Decarboxylative Difluoroalkylation of α,β‐Unsaturated Carboxylic Acids.
Authors: Li Gang , Wang Tao , Fei Fan , Su Yi‐Ming , Li Yan , Lan Quan , Wang Xi‐Sheng
Published: June 2016

For the first time, commonly available fluoro reagent (II) is used in the Ni‐catalyzed title reaction with cinnamic acid derivatives giving the 4‐aryl‐2,2‐difluorobut‐3‐enoates in good to high yields.
ChemInform Abstract: Palladium‐Catalyzed Double‐Suzuki—Miyaura Reactions Using Cyclic Dibenziodoniums: Synthesis of o‐Tetraaryls.
Authors: Zhang Yanxia , Han Jianwei , Liu Zhen‐Jiang
Published: June 2016

The title reaction of dibenziodonium triflates with arylboronic acids offers a straightforward access to a range of o‐tetraaryls (III), (V), and (VII).
ChemInform Abstract: Direct Asymmetric Friedel—Crafts Reaction of Naphthols with Acetals Catalyzed by Chiral Broensted Acids.
Authors: Qin Long , Wang Pei , Zhang Yixin , Ren Zhengxiang , Zhang Xin , Da Chao‐Shan
Published: June 2016

For the first time, regioselective asymmetric Friedel—Crafts reactions of naphthols with arylaldehyde dimethylacetals using a chiral BINOL‐derived phosphoric acid catalyst are reported, though modest yields and enantioselectivities are obtained only.
ChemInform Abstract: Chlorine‐Free Synthesis of Organic Alkyl Carbonates and Five‐ and Six‐Membered Cyclic Carbonates.
Authors: Pyo Sang‐Hyun , Hatti‐Kaul Rajni
Published: June 2016

Methoxycarbonylation of alcohols and synthesis of cyclic carbonates is achieved by a green protocol using dimethylcarbonate in the presence of mol.
ChemInform Abstract: A Facile Synthesis of Benzofuro[2,3‐c]quinolines via a Multicomponent Reaction and Staudinger—Aza‐Wittig—Dehydroaromatization Sequence.
Authors: Wei Jie , Nie Bing‐Jie , Peng Rong , Cheng Xiao‐Hong , Wang Song , He Ping
Published: June 2016

Acetylacetone and ethyl acetoacetate as 1,3‐dicarbonyl components do not yield the corresponding products.
ChemInform Abstract: A Facile Approach to Optically Active Hydroquinoline‐2‐carboxylates by a One‐Pot Asymmetric Michael/Transamination/Cyclization Process.
Authors: Rong Chao , Pan Hongjie , Liu Mao , Tian Hua , Shi Yian
Published: June 2016

The title sequence starts from β,γ‐unsaturated α‐ketoesters and 1,3‐cyclohexanediones in the presence of the optically active ligand DASQ.
ChemInform Abstract: Highly Enantioselective Intermolecular Iodo‐ and Chloroamination of Enecarbamates Catalyzed by Chiral Phosphoric Acids or Calcium Phosphate Salts.
Authors: Lebee Clement , Blanchard Florent , Masson Geraldine
Published: June 2016

The title reaction with NIS and NCS proceeds in a highly dia‐ and enantioselective manner in the presence of chiral BINOL‐derived phosphoric acids or their Ca salts as catalysts.