bluuebunny/crossref_metadata_2025 huggingface dataset:
Análise de amortecimento em decremento logarítmico com acelerômetro de vibração
Authors: Ribeiro David Augusto , Santana Márcio Wladimir , Tavares Dennis Santos , Souza Pablo Henrique Machado de , Marques Kissia Juamara Pereira , Abreu Lohayne Cristina de , Furtini Ana Carolina Corrêa , Rosa Renata Lopes , Rodríguez Demóstenes Zegarra
Published: August 2021

O amortecimento é uma propriedade dos materiais que pode ocorrer em aspecto de escala micro e macroscópica. Há um crescimento no conceito da análise de marcadores de trincas internas estruturais que causam danos em materiais diversos, devido sua ampla aplicabilidade na resolução de problemas. No processo de amortecimento ocorre a perda de energia do material quando este entra em contato físico com outro material, no qual o fenômeno pode ser observado por meio de equipamentos modernos de alta sensibilidade sob ambiente controlado. Há poucos institutos de pesquisa com capacidade de análises em ensaios de amortecimento precisos com corpos de prova. O uso de dispositivo acelerômetro contorna a problemática do alto custo laboratorial envolvidos e permite maior acessíbilidade. Objetiva-se apresentar uma metodologia de análise de parâmetros associados ao fenômeno de amortecimento, fazendo-se uso de algotítmos para acesso aberto e que permita sua replicação em modelos físicos. O trabalho apresentou efciência em determinar a frequência e parâmetros associados de sinais de corpos de prova.
Revisão de terapias no aumento de resposta da atividade melanocítica para repigmentação cutânea de portadores com vitiligo
Authors: Ventura Karla Mileny Monteiro , Miranda Jonathan Potiguara de , Costa Elaine Queiroz da , Santana Diego da Silva , Rivera Juan Gonzalo Bardález , Costa Russany Silva da
Published: August 2021

O vitiligo é uma doença imunológica caracterizada pela despigmentação da pele, causando manchas acrômicas, sem predileção por sexo ou etnia. Ademais, pode provocar alterações emocionais, comprometimento da autoestima e nas relações sociais do indivíduo. Assim, esse trabalho propõe uma revisão sistemática da literatura objetivando evidenciar a eficiência de protocolos de terapias disponíveis para o vitiligo e sua correlação. Metodologia: Trata-se de um estudo de revisão sistemática, de caráter descritivo, retrospectivo realizado a partir de pesquisas nas principais bases de dados acadêmicas. Ex. PubMed, Lilacs e Periódicos Capes, etc. Assim, fez-se buscas livres de palavras relacionadas ao tema proposto: tratamento do vitiligo e associações, excluindo os trabalhos que mostraram ineficiência (baixo percentual de repigmentação) quando comparada aos tratamentos convencionais. Nesse sentido, foram encontrados 35 artigos científicos e 27 terapias distintas para o tratamento de vitiligo. Resultados e Discussão: Tais terapias foram divididas em 4 categorias: corticosteroides, fotobiomodulação, imunossupressores e antioxidantes. O uso de corticosteroides mostrou-se eficaz na estabilização da doença. Das fototerapias, a kelina agiu em 70% dos casos de repigmentação. Já os imunossupressores JAK demonstram repigmentação total ou acima de 75%. E os antioxidantes mostraram eficácia de 67% de repigmentação, com destaque para a espécie Polypodium leucotomos e Brosimum gaudichaudii com alto índice de repigmentação completa, principalmente quando associado a radiação UVB. Já o tratamento com Ginko biloba teve 80% de estabilização da doença. Conclusão: Os protocolos mostraram que a associação das fototerapias com terapias convencionais e inovadoras são mais frequentemente eficazes no tratamento do vitiligo, potencializando os resultados.
Potential for the use of coconut shell (Cocus nucifera) as an alternative fuel in the production of cassava flour
Authors: Souza Carolina Oliveira , Ramos André Luis Dantas , Dias Júnior Ananias Francisco , Fernandes Milton Marques , Marques José Jailton
Published: August 2021

The production of cassava and tapioca flour are recognized as activities merged in family culture in the North and Northeast regions of Brazil, which demand the use of firewood to feed the furnaces in the flour mills. Due to the small number of studies on this theme, this work aims to evaluate the quality of woody species commonly used as solid fuels in the production of manioc flour in the state of Sergipe, namely: Poincianella pyramidalis (“catingueira”), Cronton sonderianus (“marmeleiro”) and Piptadenia stipulacea (white “jurema”), as well as coconut shells (Cocos nucifera), as an alternative to the use of woody species. Representative samples of the materials were analyzed for parameters: total extracts, lignin, holocellulose, volatile materials, fixed carbon, ashes, higher (HHV) and lower (LHV) heating values, in addition to thermogravimetric analysis. The data were analyzed in a completely randomized design, with four treatments and three replications. The species Piptadenia stipulacea and Cocos nucifera showed high contents of total extracts (18.14%; 29.81%), lignin (29.14%; 28.18%) and fixed carbon (28.22%; 29.62%), and lower contents of holocellulose (52.72%; 42.01%) and volatile materials (70.60%; 66.14%), respectively. The species with the lowest ash content were Croton sonderianus and Piptadenia stipulacea, and the species with the highest HHV and LHV were Piptadenia stipulacea and Croton sonderianus, respectively. Regarding to the thermogravimetric properties, Cocos nucifera behaved like the other biomasses, with ignition temperature slightly lower and peak temperature higher than those for the other species. Among the species analyzed, Piptadenia stipulacea and Cocos nucifera showed the best results as combustibles for cassava flour production. Hence, dried Cocos nucifera shells can properly replace the conventional firewood.
Efeito alelopático e análise química de extratos hidroalcóolicos de Baccharis dracunculifolia, Baccharis trimera e Baccharis gaudichaudiana sobre cultivar de Lactuca sativa L.
Authors: Flach Kauane Andressa , Rosa Genesio Mario da , Volpi Gabriel Baraldi , Wastowski Arci Dirceu , Soriani Hilda Hildebrand , Bones Ubiratan Alegransi , Costa Junior Jefferson Alves da
Published: August 2021

O presente trabalho visa o estudo do efeito de extratos hidroalcóolicos de três espécies de carqueja (Baccharis trimera, Baccharis dracunculifolia e Baccharis gaudichaudiana) em diferentes concentrações sobre a germinação e crescimento inicial de alface (Lactuca sativa) e a identificação de compostos voláteis presentes nessas espécies. As sementes de alface foram distribuídas em gerbox contento papel germitest. O delineamento experimental utilizado foi o inteiramente casualizado (DIC) em esquema bifatorial (3x5), representando três espécies de carquejas e cinco concentrações dos extratos: 0,00, 0,02, 0,03, 0,04 e 0,05%, com quatro repetições. O experimento foi mantido por um período de sete dias em B.O.D. com temperatura de 17,5 ºC. A análise química dos constituintes pertencentes às três espécies analisadas foi realizada por cromatografia em fase gasosa acoplada à espectrometria de massa (CG/EM - Shimadzu, modelo QP 5050A). A composição química das carquejas resultou em 29 compostos químicos diferentes, cada espécie de Baccharis possui um composto específico que representa entre 24 e 25% de sua composição química total, sendo eles (-)-Spathulenol (24%), Alloaromadendrene oxide (25%) e 3-Cyclohexen-1-one, 3,5,5-trimethyl- (24,63%) para B. dracunculifolia, B. gaudichaudiana e B. trimera, respectivamente. Os resultados indicam que B. trimera apresenta potencial alelopático de favorecer a germinação da alface. As espécies B. dracunculifolia e B. gaudichaudiana não influenciaram na germinação das sementes de alface nas concentrações analisadas. Os extratos das B. trimera, B. dracunculifolia e B. gaudichaudiana, influenciaram negativamente o comprimento de raiz e o índice de velocidade de germinação (IVG) com o aumento nas concentrações dos extratos.
Avaliação da expansão urbana na Cidade de Maceió, Alagoas – Nordeste do Brasil
Authors: Batista Bárbara Alves , Correia Filho Washington Luiz Félix , Oliveira-Júnior José Francisco de , Santiago Dimas de Barros , Santos Carla Taciane dos
Published: August 2021

O crescimento das cidades juntamente com a formação desordenada de grandes metrópoles ao redor do mundo resulta em grandes mudanças no uso e ocupação do solo. Porém, há poucos estudos que relacionem a expansão urbana e seus efeitos nas cidades do Nordeste do Brasil (NEB). Assim, o objetivo deste estudo foi avaliar a expansão urbana em Maceió-Alagoas entre 1985 e 2020 a partir de produtos orbitais Land Surface Temperature (LST) e Normalized Difference Vegetation Index (NDVI), com a finalidade de detectar as mudanças e os seus efeitos ambientais. Para isto foram utilizados produtos orbitais adquiridos dos sistemas-sensores Landsat 5/Thematic Mapper (TM) e 8/Operational Land Imager (OLI). No estudo utilizaram-se quatro imagens para a observação da variação espaço-temporal da urbanização, correspondente aos anos de 1987,1998, 2006 e 2020. Os mapas temáticos de NDVI e LST foram gerados a partir do software de ambiente R. Os resultados obtidos apontaram alterações substanciais no uso e ocupação do solo detectado pelo NDVI, e aumento na LST ao longo dos 35 anos. Tal variabilidade ocorreu nos bairros localizados na porção norte e noroeste da cidade, resultante dos programas de incentivo do Governo Federal na década de 2009, principalmente o Complexo do Benedito Bentes (CBB) com as maiores transformações no uso e ocupação do solo, principalmente o maior aumento na LST entre 7,5-10,0°C. Os efeitos produzidos pela expansão urbana foram atenuados devido as áreas de proteção ambiental.
Estudo piloto da prevalência de neuropatia periférica em adultos diagnosticados com Diabetes mellitus tipo 2 na Atenção Primária em saúde de Divinópolis – Brasil
Authors: Nunes Alan de Castro , Silveira André Luís de Oliveira , Lopes Denise Duarte , Castro Frederico Bregunci de , Salvador Marcella Faye de Souza , Santos Vanessa Teixeira dos , Pires Mauro Ézio Eustáquio
Published: August 2021

Introdução: O diabetes mellitus do tipo 2 (DM2) assume grande impacto na saúde coletiva pela sua importância epidemiológica. Quanto às suas complicações, estas podem ser de caráter macro e microvascular. A nível microvascular, a neuropatia periférica diabética (NPD) assume um papel de considerável relevância, sendo essa a mais comum e incapacitante. Sua prevalência tem relação estreita com a população estudada, que varia entre 13 a 47%. Objetivo: Realizar um projeto piloto que sirva de modelo à mensuração da prevalência de NPD em uma determinada população de pacientes diabéticos, tomando-se como exemplo a cidade de Divinópolis - Brasil. Métodos: Foram selecionadas de forma aleatória 5 unidades básicas de saúde em Divinópolis e dessas obteve-se também de maneira aleatória uma amostra de 75 usuários diagnosticados com DM2. Feita a seleção, foi aplicado o Instrumento de Classificação de Neuropatia de Michigan (MNSI-BRASIL). Tal instrumento forneceu pontuações que podem sugerir a presença de NPD por meio de um questionário auto aplicado e exame físico dos pés. Resultados: Aplicado o Instrumento de Classificação de Neuropatia de Michigan (MNSI-BRASIL), encontrou-se uma prevalência de NPD de 44%, sendo que a prevalência em cada unidade foi: Belvedere II 40 %, São José 56%, Serra Verde 38, 46%, Central 66,6% e Niterói 33,3%. Conclusão: Os achados demonstram pontos positivos e negativos quanto ao desenho de estudo empregado e o instrumento de avaliação utilizado. Dessa forma, o presente trabalho servirá de substrato para estudos futuros de prevalência de NPD em Adultos com DM2.
Perfil sociodemográfico e clínico de pacientes com câncer no contexto da pandemia da COVID-19 em um Hospital Universitário do Nordeste: estudo transversal
Authors: Fontes Júnior José , Silva Érika Ramos , Almeida Lucas Aragão da Hora , Santos Caroline Nunes dos , Souza Julia Lorena Santos de , Bezerra David Jacinto , Matos Carlos José Oliveira , Tofani Patrícia Silva
Published: August 2021

A pandemia do COVID-19 gerou sobrecarga dos serviços público de saúde tornando-se uma barreira para administração de terapias anticâncer. A reestruturação dos serviços de saúde e a vulnerabilidade dos pacientes oncológicos contribuíram para a interrupção do tratamento anticâncer. Assim, o objetivo foi descrever o perfil sociodemográfico, clínico e principais desfechos dos pacientes adultos e idosos com câncer internados em um hospital universitário (HU), submetidos à intervenção da Fisioterapia, considerando período prévio e atual à pandemia. Estudo exploratório e retrospectivo envolvendo 71 pacientes oncológicos internados no HU nos anos de 2019 e 2020. Os dados epidemiológicos foram coletados por meio de prontuários eletrônicos. Os critérios de elegibilidade foram registro do CID primário relacionado a neoplasia e faixa etária (≥ 30 e ≥ 60 anos). A análise estatística considerou as variáveis confundidoras: idade, sexo, local onde reside, tipo de neoplasia, desfecho clínico (alta ou óbito), condutas de fisioterapia (oxigenioterapia, ventilação mecânica invasiva e não invasiva) tempo de internação. Os resultados demonstram que o sexo não foi uma variável determinante para internação. Maior incidência de internação foram observados em idosos, afrodescendentes, pacientes com câncer de cólon e reto, pulmão e, em igual percentual, cânceres de mama, estômago e orofaringe. Os pacientes que necessitaram de acompanhamento fisioterapêutico e de oxigenoterapia evoluíram o desfecho óbito, independente do tipo de intervenção (suporte ventilatório mecânico invasivo ou não invasivo). Houve diferença entre a quantidade de admissões e desfechos alta e óbito no ano de 2020 quando comparado com 2019.
A spatial approach to rainfall in Sertão do Pajeú – Pernambuco
Authors: Nascimento Gabriela Isabel Limoeiro Alves , Moreira Guilherme Rocha , Piscoya Victor Casimiro , Medeiros Raimundo Mainar de , Araújo Filho Renisson Neponuceno de , Cunha Filho Moacyr
Published: August 2021

Changes in precipitation have implications for the hydrological cycle and water resources. Climate change is expected to alter average temperature and precipitation values, increasing the variability of these events, which could cause more intense and frequent floods and droughts. The objective of this study was to characterize the rainfall in the microregion of Pajeú, in Pernambuco, as well as to provide subsidies for public policies aimed at water scarcity. For this, rainfall data were used at stations belonging to the micro-region and its surroundings, for the period from January 1980 to December 2019. In addition, to mitigate the influences caused by temporal heterogeneity, stations with large discontinuity of information. The Inverse Weighted Distance was used to perform the interpolation of data and preparation of maps with isolines of rainfall. The results show the places with the highest annual rainfall during the study period were Serra Talhada and Triunfo, and the lowest rainfall occurred in the vicinity of Ingazeira and Tabira.
Educação para a saúde no contexto online: relato de experiência
Authors: Lopes Wemíria de Fátima Lima , Silva Isabella de Matos Mendes da , Vicentini Fernando , Nihei Jorge Sadao , Santos Gilyane Silva dos , Barreto Juliel Conceição , Amor Ana Lúcia Moreno
Published: August 2021

A suspensão do ensino presencial pela pandemia do novo coronavírus em 2020 fez com que se buscassem metodologias aplicáveis à educação online. O podcast, por exemplo, é um arquivo digital de áudio transmitido por redes sociais para divulgar informações, constituindo-se em recurso educativo no processo ensino-aprendizagem. Este relato tem como objetivo apresentar o uso de metodologias no contexto da educação remota para graduandos da área da saúde. Trata-se de um estudo descritivo do tipo relato de experiência, a partir do olhar de docentes, discentes e da monitora no componente curricular Métodos de Diagnósticos Laboratoriais (MDL), no período de 14/09 a 19/12/2020, utilizando-se de momentos síncronos e assíncronos. Grupos com três ou quatro discentes elaboraram, ao longo do semestre, oito podcasts, um exemplo de procedimento operacional padrão (POP), dialogaram com docentes e monitora em ambientes virtuais e responderam sobre suas percepções quanto ao uso destas ferramentas para o processo ensino aprendizagem em um calendário acadêmico remoto. Destacam-se como respostas: 52,6% avaliaram as estratégias adotadas como muito boa e 42,1% como boa; 47,4% utilizaram o programa Anchor para gravação e edição do podcast e 73,7% não sentiram dificuldades quanto à gravação dos roteiros. Para o POP confeccionado, ficou o compromisso de realizá-lo em uma atividade extensionista, posteriormente. A busca pela melhor metodologia foi desafiadora. O podcast se mostrou uma metodologia satisfatória para o ensino da saúde no contexto da educação online para o componente curricular (MDL). Vislumbra-se socializar em comunidades diversas os podcasts produzidos, para popularizar os conhecimentos obtidos e suas relações.
IMPLEMENTASI BADAN USAHA MILIK DESA (BUM DESA) DALAM PENGEMBANGAN EKONOMI MASYARAKAT
Authors: Arifah Umi
Published: August 2021

Sebagai upaya mensejahterakan masyarakat dan memperkuat ekonomi masyarakat, Desa dapat mendirikan Badan Usaha Milik Desa (BUM Desa) sesuai dengan kebutuhan dan potensi Desa. BUM Desa ini merupakan badan usaha yang seluruh atau sebagian besar modalnya dimiliki oleh Desa melalui penyertaan modal secara langsung yang berasal dari kekayaan Desa yang dipisahkan guna mengelola aset, jasa pelayanan, dan usaha lainnya untuk sebesar-besarnya kesejahteraan rakyat. Dengan adanya BUM Desa diharapkan dapat mampu memberikan kontribusi yang signifikan terhadap pendapatan Desa untuk pembangunan Desa yang tujuan utamanya kesejahteraan masyarakat. Hasil penelitian menunjukkan BUM Desa Petanahan belum terlalu memberikan kontribusi terhadap peningkatan ekonomi masyarakat desa. Hal ini terjadi karena bidang usaha yang dilaksanakan BUM Desa Petanahan belum menyentuh masyarakat khususnya warga miskin dan dalam pelaksanaanya belum dilaksanakan secara partisipatif, transparan dan akuntabel.
Learning interest of seventh grade students towards mathematics learning media assisted by Adobe Flash CS6
Authors: Zafrullah Zafrullah , Zetriuslita Zetriuslita
Published: August 2021

Media pembelajaran matematika merupakan tempat untuk menyalurkan berbagai informasi mengenai pembelajaran matematika dengan disusun dalam teknologi maupun dalam bentuk bacaan. Tujuan dari penelitian ini adalah untuk mendeskripsikan minat belajar siswa terhadap penggunaan media pembelajaran pada materi persamaan dan pertidaksamaan linear satu variabel dengan menggunakan Adobe Flash CS6. Penelitian ini merupakan penelitian kuantitatif deskriptif dengan sampel penelitian yang digunakan yaitu peserta didik kelas VII yang terdiri dari 18 orang peserta didik yang terdiri dari sekolah yang berbeda. Instrumen penelitian yang akan dipakai adalah instrumen non-test berupa angket minat belajar peserta didik, yang akan memuat 20 pernyataan dengan 4 kriteria penilaian. Teknik analisis data yang digunakan adalah analisis deskriptif kuantitatif. Hasil akhir dari penelitian bahwa media pembelajaran Adobe Flash CS6 memberikan respon positif terhadap minat belajar dari siswa dengan rata-rata persentase keempat kategori sebesar 80.47% dan tergolong sangat baik, dengan rincian persentase kategori perasaan senang sebesar 80.00%, kategori ketertarikan siswa sebesar 80.56%, kategori tanggapan siswa sebesar 81.11%, dan kategori keterlibatan siswa sebesar 80.21%. Sehingga media pembelajaran memberikan respon positif kepada siswa.
Sugar Rush: Sugar and Science in the British Caribbean
Authors: Jacoberger Nicole A.
Published: August 2021

This article examines the contrasting evolution in sugar refining in Jamaica and Barbados incentivized by Mercantilist policies, changes in labor systems, and competition from foreign sugar revealing the role of Caribbean plantations as a site for experimentation from the eighteenth through mid-nineteenth century. Britain's seventeenth- and eighteenth-century protectionist policies imposed high duties on refined cane-sugar from the colonies, discouraging colonies from exporting refined sugar as opposed to raw. This system allowed Britain to retain control over trade and commerce and provided exclusive sugar sales to Caribbean sugar plantations. Barbadian planters swiftly gained immense wealth and political power until Jamaica and other islands produced competitive sugar. The Jamaica Assembly invested heavily in technological innovations intended to improve efficiency, produce competitive sugar in a market that eventually opened to foreign competition such as sugar beet, and increase profits to undercut losses from duties. They valued local knowledge, incentivizing everyone from local planters to chemists, engineers, and science enthusiasts to experiment in Jamaica and publish their findings. These publications disseminated important findings throughout Britain and its colonies, revealing the significance of the Caribbean as a site for local experimentation and knowledge.
‘Not at all afraid’: Queer Temporality and the School Detective Story
Authors: Baker Timothy C.
Published: August 2021

Kate Haffey has recently argued that if queer time can be seen as a turning away from narrative coherence, it suggests new possibilities for considering narrative structures more generally. Combining the narratively rigid structures of the school story and the detective novel, the four novels discussed in this article – Gladys Mitchell’s Laurels are Poison (1942), Josephine Tey’s Miss Pym Disposes (1946), Shirley Jackson’s Hangsaman (1951), and Joan Lindsay’s Picnic at Hanging Rock (1967) – disrupt conventional understandings of linear time. Depicting not only queer, or potentially queer, characters, but a queer phenomenological perspective, they challenge reader expectations with a focus on aporias and gaps, whether in terms of trauma (Jackson), the blurring of fact and fiction (Lindsay), or the prolonged delay of both crime and resolution (Tey). These novels draw attention to the insufficiency of texts to capture experience, and the inadequacy of textual authority. As such, they reveal the extent to which mid-twentieth-century women’s fiction was able to challenge the genres and narrative structures with which it was most closely associated.
‘Of her tenacious trace’: Samuel Beckett and Contemporary Art
Authors: Weiss Katherine
Published: August 2021

This chapter explores how three contemporary artists, Claire-Lise Holy, Dorothy Cross and Arlene Shechet, have been inspired by Samuel Beckett's prose and drama, works that foreground the need and agony for being perceived and the desire to be still and silent. Holy, Cross and Shechet take up Beckett's themes of gaze and petrification, particularly as seen in Beckett's works for women. For these contemporary artists, distilling the female form on paper, canvas, stone, or video is an act of creating a trace, inviting the viewer to participate, looking upon their women with empathy. Holy, whose drawings of antiquated women resemble those of Beckett's late plays, shares with Beckett the need for us to see these women. Cross, too, draws on the importance of seeing and remaining, inviting us to act our part in recognising that we are only a moment in ancient history. Her female forms, inspired by Footfalls, recede, and as they do so, we are tempted to follow. Drawn to Happy Days, Shechet asks that we look forward beginning conversations about the here, now, and the future. She asks that in the process, creatures like Winnie who cry out, are not forgotten. For this to happen, our gaze must go beyond objectifying Winnie. These artists, like Beckett, challenge us to see differently – a empathic gaze that never forgets.
Bir Kamu Kurumunda Bulunan Asbest Uygulama Merkezi ve SEM Laboratuvarında L Tipi Matris Yöntemi ile Risk Değerlendirmesi
Authors: ÜNVERDİ Şehmus , ÇETİNYOKUŞ Saliha
Published: August 2021

İş sağlığı ve güvenliği büyüklük, tehlike sınıfı gözetilmeksizin tüm işyerleri için önemli bir kavramdır. Düşük risk seviyesine sahip bir risk çok ciddi can, mal ve çevre kayıplarına yol açabilmektedir. İşin sağlıklı ve güvenli bir ortamda yerine getirilmesi, ancak tüm risk seviyeleri için ilgili kontrol ve tedbirlerin alınması ve takibi ile gerçekleştirilebilir. Bu çalışmada, tehlikeli sınıfta yer almayan bir kamu kurumunun iki ayrı bölümünde risk analizi çalışması yürütülerek olası tüm risklerin belirlenmesi ve risk azaltıcı faaliyetlerin önerilmesi amaçlanmıştır. Risk analizi, kolay ve etkin sonuçlar üreten ve seçilen işyeri için uygun olan L-tipi risk matrisi yöntemi ile gerçekleştirilmiştir. Öncelikle, işyerinde risk analizi yapılacak bölümler ve faaliyetler incelenmiş ve tehlike kaynakları belirlenmiştir. Ardından her bir tehlike kaynağı ilgili tehlike mekanizması ile ilişkilendirilerek riskler listelenmiştir. Seçilen risk analizi yöntemi ile olasılık, şiddet değerleri üzerinden risk skorları ve risk seviyeleri elde edilmiştir. Çalışma sonucunda, işyerindeki iki bölüm için 4’ü kabul edilemez risk(kırmızı), 8’i dikkate değer risk (sarı) ve 1’i kabul edilebilir risk (yeşil) olmak üzere toplam 13 risk tespit edilmiştir. Belirlenen risk sayısı az olmasına rağmen sadece risklerin%7,6’ sının kabul edilir seviyede bulunması, ilgili bölümlerin riskli olduğunu göstermiştir. Özellikle, kabul edilemez (kırmızı) risklerin belirlendiği kimyasal tehlike kaynaklarına yönelik acil önlemler alınması gereği gösterilmiştir.
A Weak-Consistency–Oriented Collaborative Strategy for Large-Scale Distributed Demand Response
Authors: Liu Yu , Gao Tian , Sun Xiaolong , Yang Zexin , Zhang Yujia , Gao Shan , Huang Xueliang
Published: August 2021

Large-scale distributed demand response is a hotspot in the development of power systems, which is of much significance in accelerating the consumption of new energy power generation and the process of clean energy substitution. However, the rigorous distributed algorithms utilized in current research studies are mostly very complicated for the large-scale demand response, requiring high quality of information systems. Considering the electrical features of power systems, a weak-consistency–oriented collaborative strategy is proposed for the practical implementation of the large-scale distributed demand response in this study. First, the basic conditions and objectives of demand response are explored from the view of system operators, and the challenges of large-scale demand response are discussed and furthermore modelled with a simplification based on the power system characteristics, including uncertainties and fluctuations. Then, a weakly consistent distributed strategy for demand response is proposed based on the Paxos distributed algorithm, where the information transmission is redesigned based on the electrical features to achieve better error tolerance. Using case studies with different information transmission error rates and other conditions, the proposed strategy is demonstrated to be an effective solution for the large-scale distributed demand response implementation, with a robust response capability under even remarkable transmission errors. By integrating the proposed strategy, the requirement for the large-scale distributed systems, especially the information systems, is highly eased, leading to the acceleration of the practical demand response implementation.
A Review of Green Synthesis of Metal Nanoparticles Using Algae
Authors: Mukherjee Abhishek , Sarkar Dhruba , Sasmal Soumya
Published: August 2021

The ability of algae to accumulate metals and reduce metal ions make them a superior contender for the biosynthesis of nanoparticles and hence they are called bio-nano factories as both the live and dead dried biomass are used for the synthesis of metallic nanoparticles. Microalgae, forming a substantial part of the planet’s biodiversity, are usually single-celled colony-forming or filamentous photosynthetic microorganisms, including several legal divisions like Chlorophyta, Charophyta, and Bacillariophyta. Whole cells of Plectonema boryanum (filamentous cyanobacteria) proved efficient in promoting the production of Au, Ag, and Pt nanoparticles. The cyanobacterial strains of Anabaena flos-aquae and Calothrix pulvinate were used to implement the biosynthesis of Au, Ag, and Pt nanoparticles. Once synthesized within the cells, the nanoparticles were released into the culture media where they formed stable colloids easing their recovery. Lyngbya majuscule and Chlorella vulgaris have been reported to be used as a cost-effective method for Ag nanoparticle synthesis. Dried edible algae (Spirulina platensis) was reported to be used for the extracellular synthesis of Au, Ag, and Au/Ag bimetallic nanoparticles. Synthesis of extracellular metal bio-nanoparticles using Sargassum wightii and Kappaphycus alvarezi has also been reported. Bioreduction of Au (III)-Au (0) using the biomass of brown alga, Fucus vesiculosus, and biosynthesis of Au nanoparticles using red algal (Chondrus crispus) and green algal (Spyrogira insignis) biomass have also been reported. Algae are relatively convenient to handle, less toxic, and less harmful to the environment; synthesis can be carried out at ambient temperature and pressure and in simple aqueous media at a normal pH value. Therefore, the study of algae-mediated biosynthesis of metallic nanoparticles can be taken toward a new branch, termed phyco-nanotechnology.
Validation of the Prospective Memory Concerns Questionnaire (PMCQ)
Authors: Sugden Nicole , Thomas Matt , Kiernan Michael , Wilesmith Michele
Published: August 2021

Prospective memory (PM), the ability to remember to complete intended tasks, is essential for successfully completing activities of daily living. PM impairments are common in people with neuropathology such as acquired brain injury and dementia. These PM impairments affect individuals’ capabilities in key aspects of daily living including their health, safety, and independence. The Prospective Memory Concerns Questionnaire (PMCQ) was designed as a self-report measure to understand individuals’ concerns about their memory. This questionnaire may help identify issues with PM which in turn may assist clinicians in the targeted implementation of memory compensation strategies. The PMCQ was developed using Rasch and classical test methodologies, with subscales measuring frequency of forgetting behaviors, memory concerns, and retrieval failures. The current study aimed to confirm the factor structure of the PMCQ for use in adults in the general population. The study also aimed to examine relationships between the PMCQ and naturalistic performance-based measures of PM to determine how the self-report PMCQ could be used in conjunction with performance-based measures. A community dwelling sample of 558 adults completed the PMCQ, an event-based naturalistic PM task, and time-based naturalistic PM task. Confirmatory factor analyses (CFAs) indicated that a higher order model with three subscales containing 35 items produced acceptable fit [RMSEA = 0.056 (90% CI 0.054, 0.060), SRMR = 0.062, CFI = 0.915, TLI = 0.909] The PMCQ demonstrated good internal consistency (total α = 0.95, subscales: α = 0.88–0.89). The Forgetting Behaviors subscale significantly correlated with performance on the event-based naturalistic PM task (r = −0.14, p < 0.01). The Memory Concerns and Retrieval Failures subscales did not correlate significantly with performance-based PM tasks. These findings suggest that the PMCQ may be best suited for assessing individuals’ concerns about their forgetting behaviors and identifying appropriate compensation strategies or support services. It is recommended that the PMCQ be used alongside performance-based PM tasks and other cognitive measures to comprehensively assess PM. It was concluded that the PMCQ is a suitable measure for use in adults in the general population. Further validation research of the PMCQ in general population and clinical samples will determine the measures’ sensitivity and specificity in identifying PM impairments.
Prognostic Nomogram for Acute Myeloid Leukemia Patients With Biallelic CEBPA Mutations
Authors: Xu Xiaoyu , Cai Wenzhi , Cai Ping , Zhang Ling , Yao Hong , Zhang Tongtong , Shen Hongjie , Chen Suning
Published: August 2021

Adult acute myeloid leukemia (AML) patients with biallelic mutations of CEBPA (biCEBPA) displays a favorable clinical outcome, and is defined as a unique entity in the 2016 World Health Organization classification. However, due to the intrinsic characteristics of the mutation, existence of co-occurring mutations and diversified gene expression signature, the prognosis of these patients needs to be analyzed in a more systematic way. In this study we evaluated the genetic characteristics and clinical outcome in a cohort of 137 biCEBPA AML cases, and proposed a prognostic nomogram to predict the overall survival (OS) of based on the clinical variables selected by multivariate Cox regression model in training cohort, including age, white blood cell count, co-existence of DNMT3A and CSF3R mutation and whether patients could achieve complete remission after induction therapy. The area under the receiver operating characteristic (ROC) curves for 3 and 5-year OS were 0.833 and 0.863, respectively. RNA sequencing of 4 relapsed patients showed that over-expression of VMP1 was an indicator of poor prognosis of biCEBPA AML patients. In conclusion, this prognostic nomogram might provide a more accurate prediction of the clinical outcomes of biCEBPA AML patients.
Is Adjuvant Chemotherapy Beneficial to All Patients With pT3N0M0 Stage Gastric Cancer?
Authors: Huang Jiao-Bao , Lu Jun , Wu Dong , Xu Bin-bin , Xue Zhen , Lin Guo-Sheng , Zheng Hua-Long , Shen Li-li , Lin Jia , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Chen Qi-Yue , Cao Long-Long , Zheng Chao-Hui , Huang Chang-Ming , Li Ping
Published: August 2021

Background

The efficacy and benefits of adjuvant chemotherapy (AC) for patients with gastric cancer pT3N0M0 remain controversial.

Methods

We prospectively collected and retrospectively analyzed 235 patients with pT3N0M0 gastric cancer who underwent radical resection between February 2010 and January 2016. Patients were divided into two groups: the surgery-alone (SA) group (n = 82) and the AC group (n = 153). We analyzed the effects of AC on the overall survival (OS) and recurrence-free survival (RFS), and the relationship between the number of chemotherapy cycles (CC) and recurrence rate (RR).

Results

The 5-year OS and RFS of the participants were 80.9% and 87.7%, respectively, and those in the AC group were significantly higher than those in the SA group (86.9% vs. 69.5%, p = 0.003). The RFS of the AC and SA groups were 88.9% and 85.4%, respectively; the difference was not statistically significant (p = 0.35). The independent risk factors affecting the OS were perineural invasion-positive (PNI+) (HR = 2.64, 95%CI: 1.45–4.82, p = 0.003) and age ≥ 65 years (HR = 2.58, 95%CI: 1.39–4.8, p = 0.003). The independent risk factor affecting the RFS was also PNI+ (HR3.11; 95%CI: 1.48–6.54, p = 0.003). Stratified analysis revealed that postoperative AC can significantly improve the OS of PNI+ patients (AC group versus SA group: 84.1% vs. 45.5%, p = 0.001) and RFS (86.4% vs. 63.6%, p = 0.017). However, perineural invasion negative (PNI-) patients did not show the same results (p = 0.13 and p = 0.48, respectively). According to the number of CC, divided into CC < 3 groups and CC ≥ 3 groups, the cumulative RR in the CC ≥ 3 group of patients with PNI+ was significantly lower than that of the CC < 3 group (7.4% vs. 28.2%, p = 0.037).

Conclusion

For pT3N0M0 gastric cancer patients with PNI+, at least three cycles of postoperative AC can significantly reduce the overall RR. This finding should be verified by using large external sample data.
Integrated Methylome and Transcriptome Analyses Reveal the Molecular Mechanism by Which DNA Methylation Regulates Kenaf Flowering
Authors: Li Zengqiang , Tang Meiqiong , Luo Dengjie , Kashif Muhammad Haneef , Cao Shan , Zhang Wenxian , Hu Yali , Huang Zhen , Yue Jiao , Li Ru , Chen Peng
Published: August 2021

DNA methylation regulates key biological processes in plants. In this study, kenaf seedlings were pretreated with the DNA methylation inhibitor 5-azacytidine (5-azaC) (at concentrations of 0, 100, 200, 400, and 600 μM), and the results showed that pretreatment with 200 μM 5-azaC promoted flowering most effectively. To elucidate the underlying mechanism, phytohormone, adenosine triphosphate (ATP), and starch contents were determined, and genome-wide DNA methylation and transcriptome analyses were performed on anthers pretreated with 200 μM 5-azaC (5-azaC200) or with no 5-azaC (control conditions; 5-azaC0). Biochemical analysis revealed that 5-azaC pretreatment significantly reduced indoleacetic acid (IAA) and gibberellic acid (GA) contents and significantly increased abscisic acid (ABA) and ATP contents. The starch contents significantly increased in response to 200 and 600 μM 5-azaC. Further genome-wide DNA methylation analysis revealed 451 differentially methylated genes (DMGs) with 209 up- and 242 downregulated genes. Transcriptome analysis showed 3,986 differentially expressed genes (DEGs), with 2,171 up- and 1,815 downregulated genes. Integrated genome-wide DNA methylation and transcriptome analyses revealed 72 genes that were both differentially methylated and differentially expressed. These genes, which included ARFs, PP2C, starch synthase, FLC, PIF1, AGL80, and WRKY32, are involved mainly in plant hormone signal transduction, starch and sucrose metabolism, and flowering regulation and may be involved in early flowering. This study serves as a reference and theoretical basis for kenaf production and provides insights into the effects of DNA methylation on plant growth and development.
Carbon Smart Strategies for Enhanced Food System Resilience Under a Changing Climate
Authors: Yeboah Stephen , Owusu Danquah Eric , Oteng-Darko Patricia , Agyeman Kennedy , Tetteh Erasmus Narteh
Published: August 2021

There is an urgent need to match food production with increasing world population through identification of sustainable land management strategies. However, the struggle to achieve food security should be carried out keeping in mind the soil where the crops are grown and the environment in which the living things survive, especially under rainfed agricultural system. Rainfed agricultural ecosystem is extremely fragile, improving soil fertility and reducing greenhouse gas emission are key factors for developing sustainable agriculture. Moreover, society increasingly expects agriculture to be more sustainable, by decreasing irrigation and mineral fertilizer inputs. Increasing food production sustainably through efficient use of resources will strongly contribute to food security, sustainable agriculture development, and increased climate change resilience. This paper addresses the effects of carbon smart technologies on greenhouse gas emission, soil quality and crop productivity in rainfed agro ecological environment. This paper hypothesized that application of carbon smart technologies could improve soil physical and chemical properties to enhance GHG mitigation and crop production. Carbon smart technologies highlighted in this paper include minimum tillage, crop residue retention, agroforestry, biofuels, integrated nutrient management and land use management systems. This paper review and discusses the work done on carbon smart technologies in different agro-ecological regions so as to understand its impact from the perspectives of the soil, the crop and the environment. The impact of conservation agriculture on greenhouse gas emissions and the underlying mechanism in different agroecological environments have been discussed. A detailed case study and tremendous advancements on the strength of integration of trees and shrub as carbon smart technologies in improving soil and crop productivity is highlighted immensely. The paper concludes with recommendations for encouraging and improving adoption by smallholder farmers to ensure more efficient and sustainable food system. This systematic review will primarily contribute to the achievement of the following Sustainable Development Goals (SDGs), particularly SDG1 (No poverty), SDG2 (Zero hunger), SDG5 (Gender equality) and SDG13 (Climate action).
Effects of the Foliar Application of Potassium Fertilizer on the Grain Protein and Dough Quality of Wheat
Authors: Gu Xiaoyan , Liu Yang , Li Na , Liu Yihong , Zhao Deqiang , Wei Bin , Wen Xiaoxia
Published: August 2021

Potassium (K) has a significant effect on wheat yield and quality. Owing to the limitations of irrigation and production costs, soil-based applications of potassium fertilizer are not performed in wheat production on the Loess Plateau of China. In the late growth stage of wheat, potassium deficiency occurs even under sufficient nitrogen/phosphorus (N/P) levels, so it is necessary to supplement potassium through foliar spraying. However, there are few studies on the effect of the foliar application of potassium fertilizer (KFA) on wheat quality. Field experiments were conducted at two experimental sites for 2 years to study the effects of different potassium fertilizer application levels and periods on wheat yield and quality. The results showed that KFA had no significant effect on the yield of the wheat variety Xinong 20 (XN20) but increased the yield of the wheat variety Xiaoyan 22 (XY22). The improvement effect of KFA on the wet gluten content and stabilization time (ST) of XN20 was better than that on these parameters of XY22, while the sedimentation value (SV) and formation time (FT) showed the opposite trend. KFA significantly reduced the albumin content of the two varieties but had no significant effect on the globulin content. Compared with that at the other two stages, the potassium application in the form of potash fertilizer spray at a concentration of 60 mmol L−1 (K2) at the flowering stage (BBCH 65) significantly increased the protein content, wet gluten content, SV and gluten protein content in XN20 grains, whereas the application at 10 days after flowering (AA10, BBCH 71) at the K2 concentration was more beneficial to prolonging the dough FT. For XY22, the application of potassium fertilizer at the K2 concentration at the flowering stage increased the wet gluten and gluten protein levels and dough development time. There were significant genotypic differences in the composition and content of HMW-GS between the two varieties. KFA significantly increased the levels of the 1, 7 + 8, and 4 + 12 subunits in XN20 and the 1 subunit in XY22, but had no significant effect on the 2 + 12 subunit in XY22. Partial least squares path modelling (PLS-PM) analysis showed that the processing quality indexes (SV, FT, ST) and gluten protein and HMW-GS levels were regulated by the potassium fertilizer foliar spraying stage and concentration and revealed in part that KFA affected the processing quality by affecting the HMW-GS content.
Low Outcrossing from an Apple Field Trial Protected with Nets
Authors: Schlathölter Ina , Dalbosco Anna , Meissle Michael , Knauf Andrea , Dallemulle Alex , Keller Beat , Romeis Jörg , Broggini Giovanni A. L. , Patocchi Andrea
Published: August 2021

Regulatory compliance of experimental releases into the environment of not yet approved genetically modified plants often requires implementation of measures to reduce the dispersal of reproductive material. To study the impact of nets on pollen flow in an experimental field site in Switzerland, non-GM apple varieties ‘Ladina’ and ’Nicogreen’ were planted inside and outside a netted plot, respectively. Seeds harvested from mature fruits were germinated and the paternal variety of the seedlings was determined using simple sequence repeat (SSR) molecular markers. We demonstrate that pollination frequency from trees inside the netted plot to trees outside over a two-year (2018 and 2019) study of 4500 seedlings is 0.6% (26 seedlings). Moreover, these outcrossing events decreased with increasing distance from the pollen donor. Over the study period, we found on average 0.9%, 0.5%, 0.4% and 0.09% of the seedlings derived from apples of ‘Nicogreen’ trees at 8 m, 15 m, 72 m and 117 m being generated by fertilisations of ‘Ladina’ pollen, respectively. In comparison, 48.3% (2018 season) and 75.1% (2019 season) of examined ‘Ladina’ seedlings in the netted plot originated from ‘Nicogreen’ tree pollen outside the netted plot. The results suggest that insect netting is effective in minimizing egress of apple pollen from an experimental site and that the likelihood of outcrossing is reduced further (<0.1%) when there are no compatible apple trees within a radius of 100 m of the pollen donor. These data are important for biosafety research/regulation to aid understanding of pollen flow in experimental field sites.
Neural Precursor Cells Expanded Inside the 3D Micro-Scaffold Nichoid Present Different Non-Coding RNAs Profiles and Transcript Isoforms Expression: Possible Epigenetic Modulation by 3D Growth
Authors: Messa Letizia , Barzaghini Bianca , Rey Federica , Pandini Cecilia , Zuccotti Gian Vincenzo , Cereda Cristina , Carelli Stephana Carelli , Raimondi Manuela Teresa
Published: August 2021

Non-coding RNAs show relevant implications in various biological and pathological processes. Thus, understanding the biological implications of these molecules in stem cell biology still represents a major challenge. The aim of this work is to study the transcriptional dysregulation of 357 non-coding genes, found through RNA-Seq approach, in murine neural precursor cells expanded inside the 3D micro-scaffold Nichoid versus standard culture conditions. Through weighted co-expression network analysis and functional enrichment, we highlight the role of non-coding RNAs in altering the expression of coding genes involved in mechanotransduction, stemness, and neural differentiation. Moreover, as non-coding RNAs are poorly conserved between species, we focus on those with human homologue sequences, performing further computational characterization. Lastly, we looked for isoform switching as possible mechanism in altering coding and non-coding gene expression. Our results provide a comprehensive dissection of the 3D scaffold Nichoid’s influence on the biological and genetic response of neural precursor cells. These findings shed light on the possible role of non-coding RNAs in 3D cell growth, indicating that also non-coding RNAs are implicated in cellular response to mechanical stimuli.