bluuebunny/crossref_metadata_2025 huggingface dataset:
MAKİNE İMALAT TEKNOLOJİLERİNİN EVRİMİ VE GELECEĞİ EKLEMELİ İMALAT: CITESPACE BİBLİYOMETRİK HARİTALAMA UYGULAMASI
Authors: KILIÇ Sabiha
Published: March 2023

Çalışmanın amacı, makine imalat teknolojileri alanında gerçekleştirilen bilimsel eserlerin akademik gelişim süreçlerini incelemektir. Çalışma, makine imalat teknolojileri alanındaki bilimsel gelişmelerin akademik literatüre yansımasının bir projeksiyonunu sunmayı amaçlamaktadır. Çalışma kapsamında makine imalat teknolojileri alanındaki başlıca araştırma konularının neler olduğu, güncel çalışma konuları, birbiriyle bağlantılı alanlar, en aktif alanlar, alanın gelişim tarihindeki kritik geçişler ve dönüm noktaları ile atıf patlaması olan yazar, kavram ve ülke modelleri ayrıntılı olarak incelenmiştir. Çalışmanın iki veri seti bulunmaktadır. Birinci veri seti 13.551 bilimsel eserden oluşmaktadır. Birinci veri seti, WoS bibliyografik veri tabanında “TS=Machine Manufacturing Technologies” anahtar kelimesi taranılarak elde edilmiştir. İkinci veri seti WoS bibliyografik veri tabanında “TS=Machine AND TS=Manufacturing AND TS=Technologies AND TS=Additive” anahtar kelimeleri taranılarak elde edilmiştir. İkinci veri seti 1.976 bilimsel eserden oluşmaktadır. Veri setlerinde yer alan bilimsel eserlerin görselleştirilmesi ve alana ilişkin eğilimlerin incelenmesi amacıyla CiteSpace bibliyometrik haritalama programlarından yararlanılmıştır
Differentiation of Rheumatoid Arthritis From HCV Infection: Rheumatoid Factor, Anti-Cyclic Citrullinated Peptide or Anti-Mutated Citrullinated Vimentin?
Authors: Kaptanoğlu Ece , Nadir Işılay , Bakıcı Zahir , Hayta Emrullah , Türkmen Mehmet , Sezer Hafize , Hizmetli Sami , Elden Hasan
Published: March 2023

Objective: Differentiation of rheumatoid arthritis (RA) from other diseases with joint involvement such as hepatitis-C virus (HCV) infection represents a diagnostic problem. In addition to the rheumatoid factor (RF), more specific and sensitive auto-antibodies are under evaluation in recent years with conflicting results. In this study, we tested the diagnostic value of rheumatoid factor, anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) in distinguishing RA from hepatitis C patients.

Materials and Methods: Sera of 34 RA patients and 30 hepatitis C patients were tested for RF, anti-CCP anti-MCV. Disease activity was determined by disease activity score (DAS-28) 28 in RA and by modified Knodell score in hepatitis C patients. Extra-articular involvement in RA and rheumatologic involvement in hepatitis C patients were documented.

Results: In roc analysis, area under curve (AUC) was the highest in anti-CCP. Sensitivity and specificity was 82% and 53%, 79%, and 96% and 70%, and 73% for RF, anti-CCP and anti-MCV respectively. DAS-28 has a weak correlation with RF (r=0.406), anti-CCP (r=0.433), and anti-MCV (r=0.453). There was no difference between the patients in autoantibody levels regarding extra-articular involvement and DAS-28 in RA, and joint involvement in hepatitis C patients.

Conclusion: Anti-MCV antibodies may be useful in distinguishing RA however it seems to have no additional value over anti-CCP or RF in hepatitis C patients. Anti-CCP antibodies are more reliable in diagnosis of RA due to their high specificity. (Turk J Rheumatol 2010; 25: 19-23)
Overcoming Challenges in Implementing Automation and AI in Small Businesses
Authors:   Lead Management Consultant, SKS Consulting & Advisors, India, Sharma Satish
Published: March 2023

Small businesses are increasingly implementing automation and artificial intelligence (AI) technologies in order to achieve growth and competitiveness in the modern business landscape. These technologies have many benefits, such as increased efficiency, reduced costs, better decision-making, and a better customer experience. Even though automation and AI technologies have many benefits, many small businesses still have trouble with them. These challenges can include resistance to change within the organization, as well as technical difficulties such as integration and interoperability issues. In this chapter, we will explore four major challenges that small businesses face when implementing automation and AI technologies: resistance to change, integration and interoperability, data management and privacy concerns, and skills and training requirements. If these challenges are not addressed effectively, they can lead to delays, increased costs, and even complete failure of automation and AI projects.
OVERVIEW OF A SOFTWARE PRODUCT “ANYLOGIC” USED IN TRAINING OF STUDENTS IN GENERAL ENGINEERING
Authors:   Konstantin Preslavsky University of Shumen, Faculty of Technical Sciences, Bulgaria, Antonov Anton
Published: March 2023

The design of a complex logistics system requires many people and resources to support the design of the various elements and stages, that can be used for specialized software products. One of the software that can be used for designing logistic systems such as warehouses, storage equipment, industrial buildings, transport schemes for road, rail, sea, air and combined transport is “AnyLogic” . Therefore the aim of this work is to present “AnyLogic” software product and its application in education of students in general engineering.
FREQUENCY OF BLOOD TYPES FROM SYSTEMS АВ0 AND RHESUS FACTOR IN PATIENTS WITH CARCINOMA OF THE VAGINAE
Authors:   KONSTANTIN PRESLAVSKY UNIVERSITY OF SHUMEN, FACULTY OF NATURAL SCIENCE, DEPARTMENT OF BIOLOGY,115 UNIVERSITETSKA STR., Boycheva Maria
Published: March 2023

The research included 115 female patients with carcinoma of the vagina (Ca vaginae). Their blood types belonging to the systems AB0 and Rhesus factor were studied. Comparing the control group of Bulgarian population statistically significant differences in the distribution of all types of AB0 system were detected. The increase in blood type A (with 23, 26% - to 66, 96%) and the decrease in blood type 0 (with 18, 54% - to 19, 13%) are especially obvious. There is no difference in Rh system. It can be assumed that having blood type A appears to be one of the risk factors for the emergence and development of the disease in the female patients.
MAGNETO-OPTIC STUDY OF CHROMIUM DOPED BI12SIO20
Authors:   KONSTANTIN PRESLAVSKY UNIVERSITY OF SHUMEN, 9700, SHUMEN, BULGARIA, Petkova Petya
Published: March 2023

Faraday rotation in Bi12SiO20:Cr (BSO:Cr) has been investigated on (100) direction at room temperature using refractive index data in the spectral region 700 – 850 nm. Verdet constant (V) spectrum is determined in the same spectral region for this crystal. The Verdet constant spectrum of pure BSO can be described by the linear dependence V-1 (λ 2) (λ is the wavelength of the light). The Cr-ions in the sillenite crystal lattice cause a deviation of Verdet constant from the mentioned linear dependence in the spectral region of the absorption impurity structure. The magneto-optic anomaly factor γ is also investigated.
A RESEARCH STUDY ON KONSTANTIN PRESLAVSKY UNIVERSITY OF SHUMEN STUDENTS` REALIZATION
Authors:   KONSTANTIN PRESLAVSKY UNIVERSITY OF SHUMEN, SHUMEN 9712, 115, UNIVERSITETSKA STR., Nikolova Snezhana
Published: March 2023

The paper presents the opinions of users, specialists and students who study at Konstantin Preslavsky University of Shumen. The period involved is 2009-2013. The paper analyzes the collected, processed and systematized data from two of the four questionnaires used by Shumen University – Questionnaire А3 for quality of education that is intended for employers and Questionnaire А4 that is intended for students who graduate Shumen University. http://uninet.shu-bg.net/upravlenienakachestvoto/anketi/.
Determinants of Integrity of Financial Statements in Indonesian Manufacturing Companies
Authors:   Faculty of Economics and Business, Universitas Mercu Buana, Oktavianthie Nuraenie , Utami Wiwik ,   Faculty of Economics and Business, Universitas Mercu Buana
Published: March 2023

This study aims to analyze the effect of Institutional Ownership, Leverage, and Company Size on the Integrity of Financial Statements either partially or simultaneously. The population used in this study are all manufacturing companies listed on the Indonesia Stock Exchange (IDX) research for three years, from 2019 to 2021. The sampling method in this study was carried out by using the simple random sampling method and obtaining 65 companies; with a 3-year observation, the total sample size is 195 sample data. The research method used is a causal model research. The type of data used in this research is secondary data. The data analysis method used in this study is multiple linear regression analysis. The results of this study indicate that Institutional Ownership, Leverage, and Company Size positively affect the Integrity of Financial Statements.
Mix Root Beet And Red Guava's Yogurt Impact On Eligible Women's Haemoglobin Level
Authors: Sari Dewi Nurlaela , Mulyani Yanyan , Rofiasari Linda , Ariani Antri , Yuliani Meda , Lubis Tika
Published: March 2023

Nutritional problems in children are closely related to the health and nutrition preparation of a woman to become a mother-to-be, in this case, eligle woman (15-49 year) who do not yet have a legal partner. The results of the Nutrition International survey in 2018 found cases of anemia in eligible wowenâ€™s in West Java of 41.93%, this is in line with the target of giving blood supplement tablets to eligible womenâ€™s, especially the adolescent group, which is still low (25.2%) and still below the target of West Java (52%). There is a need for intervention efforts to prevent anemia by optimizing the provision of iron-containing foods in addition to giving iron tablets. The purpose of this research was to determine the effect of a mix of beetroot and red guava yogurt on hemoglobin levels in eligible woman. The method used is a quasi-experiment with a one-group pre-post design approach. The sample in this study was 30 respondents using a purposive sampling technique with the inclusion criteria of mild and moderate anemia, not having allergies to yogurt ingredients, and not being on medication disease that can cause anemia. Determination of anemia by measuring hemoglobin levels with the POCT (Point of Care Testing) method. The analysis technique uses frequency distribution, normality test, and bivariate test using Wilcoxon test through SPSS version 20.0 computer software. The results showed that all respondents (100%) experienced mild anemia before being given the yogurt mix of beets and red guava. There is a significant change with a pvalue of 0.000 < alpha value (0.05). It can be concluded that giving beetroot and red guava yogurt if consumed regularly and appropriately can reduce the incidence of anemia, so it is hoped that this can be used as a policy for intervention in eligible womenâ€™s with anemia.
Hidratação enteral intracecal em equinos utilizando diferentes taxas de infusão
Authors:   , Carvalho Brenda Ventura Lopes
Published: March 2023

O papel do cavalo e sua inter-relação com o homem tem mudado ao longo do tempo. Com altas exigências impostas pelas diversas atividades desempenhadas, os cavalos estão mais predispostos aos fatores causadores de doenças. Diversas doenças dos equídeos podem cursar com desidratação, especialmente aquelas que acometam em qualquer nível o sistema digestório, como a síndrome cólica, enterites e diarreias. Apesar da ampla utilização das vias tradicionais de hidratação, existem situações nas quais elas não são indicadas. Nestes casos, a hidratação pela via intracecal surge como uma solução que permitiria a utilização das soluções eletrolíticas enterais até mesmo em cavalos onde as porções iniciais do trato gastrointestinal estejam comprometidas. Dessa forma, este estudo objetivou avaliar os efeitos de duas diferentes taxas de infusão de uma solução eletrolítica enteral neutra hipotônica, pela via intracecal, sobre os parâmetros físicos e laboratoriais de equinos hígidos, submetidos à desidratação leve. Sete cavalos foram submetidos à cirurgia e, destes, seis receberam hidratação intracecal em um delineamento Cross Over 6x2. A videolaparotomia foi realizada adaptando a técnica de Hasson. Dois portais foram confeccionados no flanco direito para acesso à cavidade abdominal. No primeiro portal foi inserido um trocarte de 10mm para passagem do endoscópio rígido. No segundo portal foi inserida uma pinça Foerster. Após localizado, o ceco foi tracionado através do portal cranial e seguro nas posições 6 e 12 horas por duas pinças Allis. Suturas de ancoragem foram confeccionas. Procedeu-se a punço incisão do ceco para colocação da sonda de Foley. Uma sutura em bolsa de fumo foi confeccionada ao redor da sonda. Os portais de acesso à cavidade abdominal foram fechados. Os tratamentos consistiram de uma solução eletrolítica enteral neutra hipotônica. A solução foi administrada pela via intracecal em duas diferentes taxas de infusão, 10 mL kg-1 h-1 e 15 mL kg-1 h-1, em fluxo contínuo durante 12 horas. Todos os animais foram submetidos ao jejum hídrico e alimentar de 24 horas antes do início da hidratação. A avaliação clínica, exame físico e exames laboratoriais, foi realizada nos tempos: T-24h, T0h, T4h, T8h, T12h e T24h, com base no início da hidratação. A técnica cirúrgica descrita foi adequada e segura para manipulação e canulação do ceco. Esta técnica pode ser realizada mais rapidamente do que uma laparotomia tradicional e é relativamente mais segura.Além disso, permite utilização imediata da cânula para hidratação intracecal, além da manutenção da sonda por longos períodos. A administração da solução eletrolítica enteral não provocou alterações prejudiciais à saúde dos cavalos. Ambas taxas de infusão foram seguras e bem toleradas. A modalidade de hidratação foi eficiente em restabelecer o grau de hidratação e volemia, sem causar desequilíbrios hidroeletrolíticos. Palavras-chave: Fluidoterapia. Fluxo Contínuo. Canulação Cecal. Videocirurgia
TO THE 90th ANNIVERSARY OF THE INSTITUTE OF NATURE MANAGEMENT OF THE NATIONAL ACADEMY OF SCIENCES OF BELARUS
Authors: Lysenko S. A. , Kamyshenka H. A.
Published: March 2023

The article is devoted to the 90th anniversary of the founding of the state scientific institution "Institute for Nature Management of the National Academy of Sciences of Belarus". The main directions of scientific, scientifictechnical and innovative activities of the Institute are given, as well as the most important scientific results obtained in the last decade, the practical implementation of the created developments is reflected. Information is provided on participation in the implementation of state programs of various types, including programs (subprograms), for which the Institute is

currently the lead executing organization, ensuring control over the efficiency and effectiveness of their implementation.

Information about the scientific schools formed and developed by the leading scientists of the Institute is given, scientific

specialties are presented, in which highly qualified personnel are trained in postgraduate and doctoral studies at the Institute.

The immediate prospects for the development of the organization are outlined.
THE MAIN RESULTS OF THE SCIENTIFIC STUDIES OF THE INSTITUTE OF NATURE MANAGEMENT OF THE NATIONAL ACADEMY OF SCIENCES OF BELARUS IN THE AREA OF MODERN GEODYNAMICS AND PALEOGEOGRAPHY OF THE CENOZOIC
Authors: Kukharik E. A. , Matveyev A. V. , Rylova T. B. , Zernitskaya V. P.
Published: March 2023

The main results of scientific studies in the area of modern geodynamics and paleogeography of the Cenozoic obtained for the recent fifteen years are given in the article. The schemes of their area distribution are created on the base of the indicates study of modern endogenic and technogenic processes, the

influence of geological factors on population dwelling comfort is characterized, the geochemical background of the quaternary sediments and radon field on the territory of Belarus are characterized. The palynological data for the sediments of the Muravinsky Interglacial and the Late Glacial-Holocene are obtained in the frameworks of the study of the dynamics of the adjoined regions of Lithuania, Poland, Ukraine and Russia, the paleorelief and paleolandscape of the optimal phases of the named time intervals of the quarter are reconstructed, corresponding chronostratigraphic schemes are developed and approved, the interregional chronostratigraphic and paleoclimatic correlation of paleogeografic events of the Pleistocene and the Late Glacial-Holocene to the adjacent regions to Belarus is done.
Chinese Investments in Nigeria and the Political Economy of Trade, 1999 - 2019: A Leadership Perspective
Authors: Nyiayaana Kialee , Jack Jackson T.C.B
Published: March 2023

This article explores the nature and patterns of Chinese-Nigeria trade relations between 1999 and 2019 through the theoretical prism of leadership. The period 1999-2019 captures the rising trends in investments and trade relations between China and Nigeria and the latter’s efforts at liberal democratization. It raises questions about how the nature of the leadership process conditions economic developments and as well shapes the nature of trade and investments between both countries. Although the article is not necessarily comparative, it demonstrates how the contrasting character of the internal leadership process throws up inclusivity, accountability, productivity and development in China, and exclusion, opportunistic behaviour and underdevelopment in Nigeria. The article thus argues that leadership is dialectically connected to the political economy of development and trade in both China and Nigeria. Drawing on historical and statistical data relating to Chinese Foreign Direct Investments, aid/loans to Nigeria and Chinese-Nigeria trade patterns, it explains that economic relations between both countries are characterized by unequal exchanges in favour of the Chinese state. The major contention of the article is that while Nigeria does benefit from Chinese trade, loans and investments in terms of job opportunities and infrastructural developments, such benefits further deepen Nigeria’s underdevelopment and dependence on China as a result of the extractive behaviour of Nigeria’s political leaders. Nevertheless, a better developmental outcome is possible in Nigeria through transformational leadership that leads to profound changes in policies, institutions and values of accountability.
UM PANORAMA SOBRE OS MECANISMOS DE RESISTÊNCIA DA CÂNDIDA ALBICANS E O TRATAMENTO DA CANDIDÍASE RECORRENTE
Authors: Dutra Nicolodi Maria Antônia , Danielli Germano
Published: March 2023

A candidíase recorrente, ou candidíase vulvovaginal recorrente (CVR), é uma patologia que afeta milhares de mulheres em todo o mundo, todos os anos. Sabe-se que os sintomas mais característicos são prurido, dor vulvar, disúria e leucorreia, e que a recorrência é determinada quando ocorrem pelo menos quatro episódios diferentes de candidíase vulvovaginal num período de 12 meses. Vários fatores podem influenciar a sua recorrência, incluindo causas genéticas, biológicas ou comportamentais. Embora a CVR seja uma doença muito comum na população, também é conhecida pelas suas complicações deletérias se não for tratada adequadamente, incluindo infertilidade, parto prematuro, aborto espontâneo e outras doenças infecciosas. O tratamento clássico recomendado para a CVR é o uso de antifúngicos, no entanto, nos últimos anos tem-se observado aumento na resistência a estes medicamentos. Em resposta, novas abordagens terapêuticas têm sido testadas, com vacinas contra a Cândida ssp., medicamentos baseados na erradicação do biofilme, nanotecnologia e peptídeos, lactobacilos e imunoterapia, como alternativas possíveis à dependência exclusiva de antifúngicos. Este estudo tem como objetivo analisar os métodos terapêuticos disponíveis para a CVR, através de uma revisão de literaturas existentes, com a finalidade de elaborar um panorama do manejo atual e das novidades a respeito do tratamento da candidíase vulvovaginal recorrente, para elucidação da prática médica diante desta queixa frequente dos consultórios médicos, tanto clínicos quanto ginecológicos.
APRENDER UMA LÍNGUA ESTRANGEIRA NA ESCOLA PÚBLICA DA REGIÃO SUL DO BRASIL: COMO ACONTECE A APRENDIZAGEM ?
Authors: Milanez Suzigan Adriana , Fernandes Daniella
Published: March 2023

A aprendizagem de uma nova língua estrangeira, agora sendo uma segunda linguagem estrangeira, oferecida no Novo Ensino Médio no Brasil, vem desde os primeiros métodos, da teoria behaviorista e o método de Skinner de condicionamento clássico, até o conceito de Chomsky. Atualmente, a proposta de aprendizagem CLIL é somar linguagens, que além de usar a mesma área do cérebro, é valorosa como conhecimento e se apoia na língua materna para aprender uma nova língua, pois inicia a partir do que o aluno sabe, do seu conhecimento empírico, para então somar conhecimentos linguísticos e, ao oportunizar ao aluno conhecer contextos culturais de uma segunda língua adicional, torna-se altamente enriquecedor. Neste contexto, nenhum espaço educacional deve se omitir de sua responsabilidade como promovedor da linguagem, tanto no âmbito educacional, quanto no âmbito social, e assim acontece nas cidades que possuem grandes comunidades de origem étnico alemã do Norte Catarinense, buscando elevar juntamente com todo o contexto escolar a aprendizagem dos alunos e preparando-os para uma vida social fora da escola, oferecendo uma educação que atenda às necessidades individuais e suas particularidades.
EFEITO DA FERTILIZAÇÃO FOSFATADA SOBRE A PRODUTIVIDADE DE FORRAGEM E MORFOGÊNESE DE PASTAGENS DE AXONOPUS PURPUSII NOS CERRADOS DE RORAIMA
Authors: Costa Newton de Lucena , Magalhães João Avelar , Bendahan Amaury Burlamaqui , Rodrigues Braz Henrique Nunes , Santos Francisco José de Seixas
Published: March 2023

O objetivo deste trabalho foi avaliar o efeito da fertilização fosfatada (0, 30, 60 e 120 kg de P2O5 ha-1) sobre a produção de forragem e características morfogênicas e estruturais de Axonopus purpusii foi avaliado em condições naturais de campo nos cerrados de Roraima. A adubação fosfatada afetou positiva e significativamente (P<0,05) a produção de matéria seca verde (MSV), taxa absoluta de crescimento, número de perfilhos planta-1, número de folhas perfilho-1(NFP), tamanho médio de folhas (TMF), área foliar perfilho-1 (AFP), taxas de aparecimento (TAF), expansão (TEF) e senescência das folhas. Os máximos rendimentos de MSV, TAC, TAF, TEF, NFP, AFP e TMF foram obtidos com a aplicação de 89,17; 112,7; 47,7; 51,9; 102,9; 101,8 e 94,8 kg de P2O5 ha-1, respectivamente. A eficiência de utilização de P foi inversamente proporcional às doses de P aplicadas.
Gender equality in Swedish academia: Unpacking the toolbox
Authors: Silander Charlotte
Published: March 2023

Gender inequalities persist among Swedish academic staff, and gender balance is especially skewed toward men in the most prestigious academic career positions, such as professorships. In this article, the measures used in Swedish universities to promote gender equality among academic staff are investigated and related to theories of gender. The study is based on interview survey data on gender and diversity policies from 14 Swedish universities with an actor–structure categorization of gender equality (GE) measures used in Sweden universities since 1990. This first comprehensive study of GE policy among Swedish universities provides unique data on what policies universities have in place and rejects the notion that individual measures are predominantly used to fight gender inequality. Universities mostly use structural measures to ‘fix’ the organization, but from this approach follows that those measures are often gender neutral and soft, indicating a strong belief in gender-neutral principles, and they might limit the effect of action.
The Dilemma of Social Media Benefits to College Programming Students
Authors: Mvurya Mgala , Mwakondo Fullgence
Published: March 2023

Social media has become part and parcel of students’ life in colleges as it occupies most of their free times. Over time, results of programming units have shown a downward trend among college students at Technical University of Mombasa in Kenya. Programming, like Mathematics, requires a lot of practice that is now consumed by social media. This study investigated the impact of Social Media on Grades in terms of hours spent and the time of day Social Media is used. Descriptive statistical research was used to gain understanding of the predictive power Social Media has on the Programming Grades. A total of 142 students pursuing Degree and Diploma courses in Information Technology participated in the study. The students were drawn from Technical University of Mombasa and Kenya Coast National Polytechnic. Over 90% of the students were active Social Media users. The research was conducted in 2018-2019 academic year. Results show that social media use could predict students who scored high grades in both Degree and Diploma courses. Such students controlled their usage of Social Media. They did not use Social Media in the early morning hours up to afternoons when they were engaged in serious studies. These students used Social Media anytime of the day - which means, in between serious study sessions. On the other hand, more average students used Social Media even in the early morning and up to afternoon sessions. Notably, more average Diploma students use Social Media at bedtime than anytime. Further research is recommended with more data using Machine Learning techniques to develop a model that will predict success or failure in Programming units depending on how one uses social media.
The Behavior of Nanovesicles of Physicochemical Profiles: Compose of β-Cyclodextrin and Cisplatin for Anti-Tumor Activity and Decrease Toxicity Affected Normal Surrounding Tumor Tissues
Authors: Panyosak Atchara
Published: March 2023

CP (cisplatin) was entrapped in lipid bilayer and β-CD-CP (β-cyclodextrin-CP) was entrapped in hydrophilic bilayer both were prepared by chloroform film method with sonication. The entrapment efficiency of CP-LPS (CP-Liposome) and β-CD-CP-LPS were 83.44 and 82.20 %, respectively, two-tailed t-test and no significant difference at the confidence interval, p < 0.05. Size distribution of CP-LPS and β-CD-CP-LPS were investigated by DLS were in range 322 and 1033 nm, respectively. CP release from CP-LPS or β-CD-CP-LPS exposed to physiological conditions as PBS at 37 °C. CP from both LPS formulations have showed an initial burst release around < 17 and < 10 %, respectively. CP-LPS and β-CD-CP-LPS maintained as plateau phase of both for four days and seven days, respectively. CP-LPS showed % cumulative controlled release CP of CP-LPS and β-CD-CP-LPS were about 15 - 16 and 10 - 11 %, respectively. CP-LPS and β-CD-CP-LPS released until 83.6 % for six days and 82 % for eight days, respectively. CP released from CP-LPS and β-CD-CP-LPS were in a controlled deportment for 10 days. β-CD-CP-LPS, CP molecules bound β-CD was exhibited in dynamic equilibrium with free drug molecules which ascribes the controlled release behavior of β-CD-CP-LPS to quietly release and prolong action, diminish dose of toxicity of cancer drug that effected to normal tissues that surrounding tumor tissue. β-CD was oligosaccharides,an attracted tumor, tumor snatch themselves as nutrient consume more than the normal tissues. Thus, β-CD-CP-LPS and low dose of normal dose of CP can damage cancer cells. This synergistic effect was saved for normal cells which surrounding tumor tissue.
HIGHLIGHTS

Nanovesicles (NVs) are a particularly attractive delivery system because of their NVs’ size, which permits carrying across biological membranes and exact target sites by a probable surface adjustment, sustained release delivers, and diminished drug dose to treat. The experiment found that β-CD-CP-LPS transported to HeLa cells in a sustained release to prolonged action. β-CD-CP-LPS, CP molecules bound within the β-CD are in dynamic equilibrium with free drug molecules, which ascribes the controlled release behavior of β-CD-CP-LPS to quietly released and long term which diminished toxicity that effected to normal tissues which surrounding tumor tissue. Moreover, β-CD was an oligosaccharide, an attracted tumor. Tumors snatch themselves as nutrient consume more than the normal Thus, β-CD-CP-LPS and a low dose of normal dose of CP can damage cancer cells. This cooperative effect was saved for normal cells which surround tumor tissue.

GRAPHICAL ABSTRACT
A Versatile Molecular Probe of Napthalimide-Derivative for Zn(II) Sensor: A Mini-Review
Authors: Das Pragyan Parimita , Mohanty Patitapaban , Barick Aruna Kumar , Mohapatra Priyaranjan , Jali Bigyan Ranjan
Published: March 2023

In recent years, many more chemists have been focused on fluorescent probe research, and significant progresses, which has been made in terms of design and use. This review begins with a brief overview of the most prevalent chemosensor design concepts, followed by a discussion of the photophysical characteristics of the 1,8-naphthalimide structure, such as great photostability, high fluorescence quantum yield and ease of modification which has been used in Zn2+ cation sensing to date. The contributions of the fluorescent probes built on the 1,8-naphthalimide based platform in the field of chemical sensing, biological sensing, pharmaceutical chemistry, environment and food safety in the last 10 years are then systematically introduced by discussing the probe’s fluorescence behavior in the corresponding recognition process. Simultaneously, we intend to build an overall review on fluorescent chemical sensor that will be able to play larger and more interesting role in the future.
HIGHLIGHTS

Napthalimide-based fluorescence molecular probes for zinc(II) detections are described
Various napthalimide derivatives are described based on their potent applications
Fluorescence chemosensors are described

GRAPHICAL ABSTRACT
ESTIGMA EN OBESIDAD: VALIDACIÓN AL ESPAÑOL DE LA ESCALA DE CREENCIAS SOBRE LAS PERSONAS CON OBESIDAD (BELIEFS ABOUT OBESE PERSONS SCALE - BAOP)
Authors:   Centro Katz. Ciudad Autónoma de Buenos Aires, Argentina, Lewitan Dalia , Katz Mónica , Formoso Jesica , Anger Vanesa ,   Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Argentina
Published: March 2023

Introduction: Stigma towards people with obesity perpetuates the pathology. If discrimination is carried out by health professionals, it distances people from the health care system. Objective: to evaluate the validity and reliability of the Scale of Beliefs about Obese People (BAOP) adapted to Spanish in a sample of health professionals in Argentina. Materials and methods: 186 participants (71.5% women, mean age 38 ± 46 years, mean BMI: 23.4 ± 27 kg/m2; mean time since graduation 12.2 ± 19.7 years) completed an online questionnaire with demographic data, the Scale of Beliefs about Obese People (BAOP) adapted to Spanish and the Scale of Antifat Attitudes (AFA). Results: Confirmatory factor analysis showed a 3-factor solution that accounts for the 42% of the variance of the scores (KMO =.69; x72= 6.28, p = .51). Cronbach's Alpha coefficient indicated an acceptable reliability of 0.60. Pearson's correlation coefficients showed a significant negative association with older age and graduation time (Years of graduation: r = -.21, p < .01; Age: r = -.20, p < .01) suggesting that the older is the time of graduation and the age of the professional, the higher the level of stigma recorded. The stigmatizing beliefs that reached the highest level of agreement were poor eating habits (mean = -2.11) and sedentary lifestyle (mean =-1.41). Conclusion: The adaptation to Spanish of the BAOP scale show acceptable levels of validity and reliability to assess stigma towards people with obesity. In the sample of health professionals, a higher level of stigma is observed at older ages and longer professional registration. Sedentary lifestyle and poor eating habits were the stigmatizing beliefs with the highest level of agreement. Keywords: Stigma; obesity; discrimination; barriers in obesity.
AGROECOLOGIA E A TRILOGIA DE VALORES E ATIVIDADE CIENTÍFICA DE HUGH LACEY
Authors: Albrecht Leandro P. , Albrecht Alfredo Jr. P.
Published: March 2023

A agroecologia, seja para a agronomia, para a filosofia, ou para a sociedade como um todo, é tema significativo, e autores como Hugh Lacey souberam explorar bem o assunto. A agroecologia aparece em destaque na produção acadêmica de Lacey, e com o objetivo de identificar a presença, o papel e a progressão do tema agroecologia na trilogia “Valores e Atividade Científica”, o presente trabalho se defronta com os seguintes problemas: qual a relação da jornada e filosofia de Lacey com a agroecologia? Quais as implicações e uso do modelo de ciência e valor de Lacey sobre a agroecologia? Onde e como está a agroecologia na trilogia de valores e atividade científica? E por fim, como sintetizar o progresso do pensamento agroecológico de Lacey em sua trilogia? Considerando que para Lacey a agroecologia é um exemplar científico ou estudo de caso relevante a ser adotado, na promoção de uma ciência contextualizada, mais engajada, plural, justa e sustentável.
The scale of Facebook’s problem
depends upon how “fake news” is
classified
Authors: Rogers Richard
Published: March 2023

Ushering in the contemporary “fake news” crisis, Craig Silverman of
Buzzfeed News reported that it outperformed mainstream news on
Facebook prior to the 2016 U.S. presidential election. Here the report’s
methods are revisited for 2020. Examining Facebook user engagement
of election-related stories, and applying Silverman’s classification of fake
news, it was found that the problem has worsened. If, however, one were
to classify “fake news” in a stricter fashion, as Facebook and others do
with the notion of “false news,” the scale of the problem shrinks. A smaller
scale problem could imply a greater role for fact-checkers, while a larger
one could lead to the further politicization of source adjudication, where
labeling certain sources as “fake” results in backlash.
When misinformation migrates
Authors: Burton Anthony Glyn
Published: March 2023

This chapter investigates the political information ecologies of the
“deep vernacular web” by studying the cross-posting of links on 4chan’s
“politically incorrect” board and a host of political subreddits. It finds
that Reddit’s banning of political subreddits in June 2020 proved effective
in culling the spread of misinformation. 4chan users turned from
sharing propagandistic content towards conspiratorial links as the
2020 U.S. election approached. This turn towards conspiracy parallels
the decline in popularity of alt-right punditry on both platforms,
reflected in the shift in presence over time of these types of videos.
The chapter offers an example of how URLs and YouTube links can
be used as a cross-platform digital method in studying the spread of
misinformation.
The earnest platform
Authors: Niederer Sabine , Colombo Gabriele
Published: March 2023

Increasingly, Instagram is discussed as a site for misinformation, inauthentic
activities, and polarization, particularly in recent studies about
elections, the COVID-19 pandemic and vaccines. In this study, we have
found a different platform. By looking at the content that receives the
most interactions over two time periods (in 2020) related to three U.S.
presidential candidates and the issues of COVID-19, healthcare, 5G and
gun control, we characterize Instagram as a site of earnest (as opposed
to ambivalent) political campaigning and moral support, with a relative
absence of polarizing content (particularly from influencers) and
little to no misinformation and artificial amplification practices. Most
importantly, while misinformation and polarization might be spreading
on the platform, they do not receive much user interaction.
PERANCANGAN RUMAH SAKIT INFECTIOUS DESEASES
Authors: Munandar Aris , Darwin Muhammad
Published: March 2023

Rumah Sakit infectious Deseases Kabupaten Bireuen Provinsi Aceh merupakan suatu tempat dimana menampung pasien khusus penyakit menular, salah satunya yaitu penyakit Covid 19 yang saat ini sedang marak penyebaranya di dunia, dan ada juga beberapa penyakit menulaar lainnya yang pernah terjadi di belahan dunia ini antaralain yaitu Kolera (1817-1823) Pandemi kolera pertama dimulai di Jessore, India, HIV/ AIDS (1976 hingga sekarang), Hong Kong Flu atau H3N2 (1968-1970), SARS (2002-2003) dan Ebola (2014-2016). Sehingga sedikit tidaknya masyarakat yang terkena penyakit menular ini dapat dirawat secara instensif dan juga terhindar dari penyebaran penyakit tersebut. Dalam hal ini penulis mendesain bangunan tersebut guna untuk meningkatkan fasilitas serta ruang isolasi yang memadai juga sebagai antisipasi akan terjadinya penyakit menular lainnya, dilihat dari jenis-jenis penyakit menular yang terus berganti dan muncul tiap tahunnya. Lokasi desain terletak di kawasan juli, Kecamatan Juli yang merupakan kawasan lingkup perkebunan sawit. Perancangan rumah sakit infectious deseases ini di awali dengan pendekatan studi literatur dan studi banding yang diperoleh melalui perpustakaan dan internet, kemudian dilanjutkan dengan tahap identifikasi masalah yang muncul dalam proses perancangan dan melakukan analisis-analisis untuk memberikan tanggapan desain yang sesuai dengan kondisi lingkungan dan fisik bangunan. Hasil pembahasan analisis dituangkan dalam bentuk konsep perancangan gedung dengan tema Arsitektur Ramah Lingkungan atau Green Architecture dan perpaduan konsep kedaerahan yang menjadi acuan dalam perancangan bangunan.
KARAKTERISTIK CAMPURANASPAL BETON DENGAN SUBSTITUSI LIMBAH ETHYLENE VINYL ACETATE MENGGUNAKAN GRADASI TERBUKA
Authors: Iqbal Deni , Ramadhani Fajria
Published: March 2023

Jalan yang tidak memiliki fasilitas drainase yang baik di beberapa daerah khususnya di Aceh yang sering tergenang banjir pada saat musim hujan dapat membuat kekuatan bahan dari campuran aspal semakin lama semakin berkurang, serta dapat menimbulkan kerusakan pada bagian perkerasan jalan seperti terkikisnya lapisan permukaan jalan, hal tersebut membuat permukaan aspal menjadi kasar ditambah dengan kemampuan menerima beban pada kendaraan yang melintas dapat membuat aspal rusak dalam waktu yang relatif singkat, Untuk itu perlu adanya inovasi dengan menggunakan alternatif bahan pengganti seperti limbah Ethylene Vinyl Acetate (EVA), Modifikasi aspal penetrasi 60/70 bertujuan untuk mengetahui karakteristik campuran aspal beton AC-WC yang disubstitusi limbah EVA. Serta bertujuan untuk mengetahui persentse substitusi EVA yang menghasilkan karakteristik optimum pada gradasiterbuka. Pada penelitian ini parutan limbah EVA disubstitusikan sebanyak 1,5%, 2,5%, dan 3,5% terhadap berat aspal. Hasil yang didapat dari penelitian ini yaitu karakteristik campuran aspal dengan substitusi EVA menggunakan gradasi terbuka belum memenuhi persyaratan Bina Marga 2010 revisi 3 (2014) pada nilai VIM yaitu pada substitusi 3,5%EVA, Sedangkan untuk nilai stabilitas, flow, MQ, density, VFA dan VMA sudah memenuhi persyaratan Bina Marga 2010 revisi 3 (2014).. Persentase variasi EVA optimum pada gradasi terbuka diperoleh pada substitusi 1,5%.
PENGARUH PENGGUNAAN PIPA PADA KOLOM TERHADAP KUAT TEKAN BETON MUTU K-250, K-225 DAN K-200
Authors: Suhaimi Suhaimi , Mahsul Hasan
Published: March 2023

Abstrak : Penggunaan pipa PVC pada kolom karena tuntutan estetika dapat mengakibatkan terjadinya rongga pada sebuah struktur yang berdampak pada berkurangnya luas penampang dan volume beton, sehingga akan mempengaruhi kekuatan tekan beton. Penggunaan pipa di dalam kolom diperbolehkan dalam SNI-03-2847-2002 dengan syarat tidak boleh melebihi dari 4% dari luas penampang. Saat ini banyak terdapat penggunaan pipa PVC dengan luas penampang 5%-8% melebihi dari yang persyaratan yang telah di tetapkan dalam SNI-03-2847-2002. Tujuan penelitian ini untuk mengetahui persentase kehilangan kuat tekan beton pada variasi yang berbeda dan manakah variasi mutu beton yang memiliki pengaruh paling besar terhadap kehilangan kuat tekan. Uji eksperimen dilakukan terhadap beberapa variasi mutu beton yaitu K-250, K-225 dan K-200 dengan model berupa selinder ukuran 15cm x 30 cm yang diberi Pipa PVC diameter 1,5 Inch dan tanpa Pipa PVC (benda uji normal), pengujian dilakukan pada umur 28 hari. Hasil penelitian memberikan kesimpulan bahwa terjadi penurunan nilai kuat tekan beton yang besar akibat berkurangnya luas penampang pada berbagai variasi mutu beton yang direncanakan, pengunaan Pipa PVC 1,5 Inch (11,395 Cm2 ) pada mutu beton K-250 mengalami penurunan kuat tekan beton sebesar 15,458%, mutu beton K-225 mengalami penurunan kuat tekan beton sebesar 44,201% dan mutu beton K-200 mengalami penurunan kuat tekan beton sebesar 49,538%. Berdasarkan hal tersebut juga mengapa SNI-03-2847-2002 membatasi penggunaan/penempatan pipa tidak boleh melebihi sebesar 4% dari luas penampang.
PENGARUH SUBSTITUSI PASIR TERHADAP KUAT TEKAN MORTAR PLASTIK, STUDI KASUS CAMPURAN PLASTIK BAKAR LDPE, HDPE DAN PET
Authors: Kurnia R. Dedi Iman , Nur Sofyan
Published: March 2023

Pencemaran lingkungan yang diakibatkan oleh limbah plastik sangat dominan dan menjadi isu yang mendunia dalam bidang lingkungan hidup. Upaya memanfaatkan limbah plastik untuk dijadikan bahan material bangunan merupakan salah satu alternatif yang diharapkan dapat mengurangi efek pencemaran yang terjadi. Penelitian ini bertujuan untuk menganalisis potensi dari limbah plastik bakar (LPB) untuk digunakan sebagai bahan ikat pembuatan mortar plastik. Bahan plastik yang digunakan berjenis high density polyethylene (HDPE), low density polyethylene (LDPE) dan polyethylene etilen terephalate (PET). Dilakukan variasi substitusi pasir terhadap bahan plastik, dengan asumsi dapat memperbaiki nilai kuat tekan yang dihasilkan. Variasi substitusi pasirterhadap plastik adalah sebesar 10, 20, 30, 40 dan 50 persen dari volume plastik.Benda uji mortar plastik dibuat berbentuk kubus dengan ukuran 5 x 5 x 5 cm. Pengujian kuat tekan dilakukan setelah benda uji mencapai umur 14 hari. Hasil pengukuran berat jenis benda uji mortar plastik berkisar antara 941,3 Kg/M3 sampai dengan 1972 Kg/M3. Hasil pengujian kuat tekan benda uji mortar plastik yang diperoleh berkisar antara 8,201 MPa sampai dengan 13,679 Mpa. Hasil pengujian kuat tekan mortar plastik berbanding lurus dengan variasi persentase substitusi pasir yang digunakan. Semakin besar persentase substitusi pasir yang digunakan semakin besar pula nilai kuat tekan yang diperoleh. Substitusi pasir yang dilakukan terbukti dapat meningkatkan kuat tekan mortar plastik. Hal ini terjadi karena material pasir memiliki kakuatan yang lebih baik dari plastik.
EVALUASI PELAKSANAANK3 PADA PROYEK KONSTRUKSI DI KABUPATEN BIREUEN
Authors: Munardy Munardy , Iq Deni
Published: March 2023

Pekerjaan konstruksi merupakan kegiatan industri yang mempunyai tingkat resiko kecelakaan kerja yang tinggi dibanding dengan industri lainnya.Adapun salah satu tindakan yang dapat dilakukan untuk pencegahan terjadinya kecelakaan kerja dengan menerapkan  program keselamatan dan kesehatan kerja.Keselamatan dan kesehatan kerja adalah upaya perlindungan yang ditujukan agar tenaga kerja dan orang lain ditempat kerja atau perusahaan selalu dalam keadaan selamat dan sehat, serta agar setiap produksi digunakan secara aman dan efisien. Penelitian ini bertujuan untuk mengetahui sampai sejauh mana programkeselamatan dan kesehatan kerjayang diterapkan pada proyek konstruksi di Kabupaten Bireuen.Pengumpulan data dilakukan melalui penyebaran kuisioner.Analisis data menggunakan analisis validitas, analisis reliabilitas dan analisis frekuensi dengan menggunakan perangkat lunak SPSS versi 20 dan Microsoft Excel 2007.Hasil analisis diperoleh sebanyak 47,84%responden menyatakan bahwa penerapan program keselamatan dan kesehatan kerja pada proyek konstruksi di Kabupaten Bireuen berada pada kualifikasi kurang baik.
ANALISA TINGKAT KERUSAKAN JALAN DENGAN PERKERASAN LENTUR MENGGUNAKAN METODE PAVEMENT CONDITION INDEX (Studi Kasus: Jalan Line Pipa Kecamatan Nibong Kabupaten Aceh Utara)
Authors: Iskandar Iskandar , Munandar Aris , Suhaimi Suhaimi
Published: March 2023

Prasarana yang terbebani oleh volume lalu lintas yang tinggi dan berulang-ulang akan menyebabkan terjadinya penurunan kualitas jalan sebagaimana indikatornya dapat diketahui dari kondisi permukaan jalan, baik kondisi structural maupun fungsionalnya yang mengalami kerusakan. Penelitian ini bertujuan untuk mengetahui jenis dan tingkat kerusakan pada permukaan jalan dan mengetahui nilai kondisi kerusakan perkerasan jalan. Metode yang digunakan dalam penelitian ini yaitu metode PCI (Pavement Condition Index).PCI (Pavement Condition Index) adalah sistem penilaian kondisi perkerasan jalan berdasarkan jenis, tingkat dan luas kerusakan yang terjadi. Tingkat PCI dituliskan dalam tingkat 0 sampai 100.Nilai 0 menunjukkan perkerasan dalam kondisi sangat rusak dan nilai 100 menunjukkan perkerasan masih sempurna. Berdasarkan hasil penelitian didapatkan jenis kerusakan yang dapat ditemukan pada ruas Jalan Line Pipa Kecamatan Nibong Kabupaten Aceh Utarayaitu  kondisi Sangant Baik (Very good) terdapat pada sta 0+100, sta 1200 + 1300, sta 1600 + 1700 kondisi Baik (Good) terdapat pada sta 100 + 200, sta 200 + 300, sta 300 + 400, sta 400 + 500, sta 700 + 800, sta 800 + 900, sta 900 + 1000, sta 1100 + 1200, sta 1300 + 1400, sta 1500 + 1600, sta 1800 + 1900, sta 1900 + 2000 kondisi Cukup (Fair) terdapat pada sta 500 + 600, sta 600 + 700, sta 1000 + 1100, sta 1700 + 1800.Berdasarkan rekomendasi darimetode PCI (Pavement Condition Index) diperoleh kondisi kerusakan rata-rata ruas Jalan Line Pipa Kec. Nibong Kab. Aceh Utara adalah sebesar 62,45%. Prioritas penanganan yang tepat dilakukan setelah mengetahui nilai PCI sebesar 62,45%  yaitu perbaikan dengan pemeliharaan berkala.
„Die Gastronomie ist raus aus der Krise“
Authors: Biehl Bernd
Published: March 2023

Die Systemgastronomie in Deutschland hat sich mit Macht zurückgekämpft und liegt weit über den Umsätzen von 2019.
Rewe Group und Hellweg planen Joint-Venture
Authors: Tewes Werner , Hofmann Janine
Published: March 2023

Die Rewe Group rückt mit ihrer Baumarktsparte an Hellweg heran. Der Kölner Konzern prüft für seine Tochter Toom den Aufbau eines Gemeinschaftsunternehmens mit dem Mittelständler. Zudem wollen die beiden Händler ihre Einkaufskooperation vertiefen.
Schlechte Zeiten für VLOG-Milch
Authors: Lenders Dirk , Murmann Christoph
Published: March 2023

Lactalis bezahlt den Rohstofflieferanten für die Leerdamerproduktion demnächst für Milch ohne Gentechnik keinen Zuschlag mehr. Auch andere Käsereien denken unter dem Druck sinkender Erlöse darüber nach, die Kosten für diesen Mehrwert einzusparen.
„Fäden laufen hier zusammen“
Authors: Falker Gerrit-Milena
Published: March 2023

Niedersachsens Ernährungsministerin Miriam Staudte erläutert, inwiefern das niedersächsische „Krisennetzwerk für die Land- und Ernährungswirtschaft“ helfen kann, im Fall von Versorgungsstörungen schnell einzugreifen.
Girocard-Gebühren waren rechtswidrig und überhöht
Authors: Bender Hanno
Published: March 2023

Nur vier von elf Schadenersatzklagen gegen die deutschen Banken wegen zu hoher Girocard-Gebühren waren erfolgreich. Die Urteile werden voraussichtlich jedoch keinen Bestand haben.
Farmer wollen nachhaltiger werden
Authors: Bender Ralf
Published: March 2023

Trockenheit, Erosion und Wetterextreme setzen die Landwirtschaft in den USA zunehmend unter Druck. Die Bereitschaft, nachhaltiger zu wirtschaften, steigt.
US-Spirituosen wachsen dank Premium und Gastronomie
Authors: Bender Ralf
Published: March 2023

Der US-amerikanische Spirituosenmarkt ist im vergangenen Jahr weiter gewachsen. Ausschlaggebend war das anhaltende Interesse an Premium-Spirituosen sowie die Erholung der Gastronomie.
Aldi und Lidl treiben Flächenerweiterung im Ausland voran
Authors: Rennack Sebastian
Published: March 2023

Deutsche Discounter investieren stark im Ausland. Aldi Süd verstärkt die Präsenz besonders in den USA und in England. Lidl setzt auf Mittel- und Osteuropa. Aldi Nord zielt auf Polen und Spanien.
Hornbach baut Vorsprung aus
Authors: Hofmann Janine
Published: March 2023

Der Baumarktkonzern Hornbach hat 2022 die Ertragskraft seiner Bestandsmärkte verbessert und baut in puncto Produktivität den Abstand zur Konkurrenz aus. Derweil hat Bauhaus mit Marktführer Obi gleichgezogen.