bluuebunny/crossref_metadata_2025 huggingface dataset:
Kandungan Senyawa Polifenol dan Aktivitas Antioksidan Daun Tumbuhan Apu-apu (Pistia stratiotes) dengan Metode Pengeringan yang Berbeda
Authors: Sudirman Sabri , Aprilia Erina , Janna Miftahul
Published: September 2022

Radikal bebas yang meningkat dapat menyebabkan kerusakan pada sel dan jaringan di dalam tubuh. Hal ini disebabkan oleh kurangnya kemampuan antioksidan dalam meredam paparan radikal bebas sehingga membutuhkan antioksidan di luar tubuh. Salah satu tumbuhan yang dapat digunakan sebagai sumber antioksidan yaitu tumbuhan apu-apu (Pistia stratiotes) karena memiliki golongan senyawa polifenol, namun senyawa polifenol bersifat termolabil sehingga proses pengeringan merupakan hal penting dalam proses preparasi dan ekstraksi. Penelitian ini bertujuan mengekstraksi senyawa polifenol dari daun tumbuhan apu-apu dengan metode pengeringan yang berbeda dan menguji aktivitas antioksidan senyawa tersebut. Pengeringan dilakukan dengan tiga metode yang berbeda, yaitu pengeringan matahari, oven pada suhu 40ºC, dan pengeringan beku (freeze drying) dengan tiga pengulangan. Data dianalisis menggunakan one-way analysis of variance (ANOVA) dengan uji lanjut Duncan dan disajikan dalam bentuk grafik. Ekstraksi menghasilkan nilai rendemen tertinggi pada pengeringan beku (15,64±1,19%) dan terendah pada pengeringan matahari (8,48±3,34%). Pengujian total polifenol dan flavonoid menghasilkan nilai tertinggi pada pengeringan beku, yaitu masing-masing sebesar 32,94±1,34 mg GAE/g sampel kering dan 146,80±5,29 mg QE/g sampel kering, sedangkan terendah pada pengeringan matahari. Adapun tingkat aktivitas antioksidan pada pengeringan beku dengan IC50 sebesar 266,33±5,77 mg/mL dan pengeringan oven sebesar 305,67±22,85 mg/mL yang memiliki aktivitas yang lebih efektif dalam menghambat radikal bebas jika dibandingkan dengan metode pengeringan matahari dengan IC50 sebesar 462,67±56,52 mg/mL). Pada peneilitian ini disimpulkan bahwa metode pengeringan beku dan oven dapat menjadi pilihan sebagai metode pengeringan yang tepat dalam mengekstrak senyawa polifenol dan flavonoid yang digunakan sebagai bahan antioksidan.
Extremely Large Off-Fault Deformation during the 2021 Mw 7.4 Maduo, Tibetan Plateau, Earthquake
Authors: Li Chenglong , Li Tao , Shan Xinjian , Zhang Guohong
Published: September 2022

The 21 May 2021 Mw 7.4 Maduo earthquake ruptured a 170 km long immature strike-slip fault within the eastern Tibetan plateau. Based on pixel correlation of pre- and postevent Sentinel-2 optical satellite images (band 8; pixel = 10 m), we determine the coseismic horizontal displacement and deformation-zone width at the surface. These results, compared with the on-fault slip from geological measurements, document that <20% of the fault displacement is localized on the fault plane, whereas as high as >80% of the fault displacement occurred as off-fault deformation (OFD), over a mean deformation-zone width of 835 m (ranging from 60 to 1670 m). The OFD% of the Maduo earthquake is significantly larger than the OFD% (28%–64%) of all other (eight in total) previously documented earthquakes occurring on immature strike-slip faults, amongst which five earthquake faults have a structural maturity (cumulative displacement) even lower than the Maduo earthquake fault. These observations may be explained by that (1) the fault maturity is not the only factor controlling the behavior of OFD or the degree of strain localization during an earthquake, or that (2) the calculated OFD includes some elastic deformation due to fault slip reduction in the shallow depth. Our results have an implication that the seismic hazard assessment of immature strike-slip faults is more challenging than previously thought.
Sinus histiocytosis with massive lymphadenopathy (Rosai Dorfman Disease) - A rare case of isolated axillary lympadenopathy diagnosed on FNAC
Authors: Banga Vineet
Published: September 2022

Rosai-Dorfman disease (Sinus Histiocytosis with Massive Lymphadenopathy) is a rare disorder characterized by overproduction (proliferation) and accumulation of histiocytes in the lymph nodes of the body causing lymphadenopathy, most often involving neck. In some cases, abnormal accumulation of histiocytes may occur in other areas of the body besides the lymph nodes (extra nodal). These areas include the skin, central nervous system, kidney, and digestive tract. The case is being reported as a rare case involving isolated axillary lymph node and was diagnosed on FNAC.
Serous papillary cystadenofibroma of ovary: A rare entity diagnosed on frozen section
Authors: Mohanty Shushruta , Behera Lipika , Patnaik Chaitali , Mishra Deepika , Acharya Shwetambari
Published: September 2022

Ovarian cystadenofibroma are rare slow growing benign epithelial ovarian neoplasms. It usually occurs as solid and cystic component. Most of the tumours are asymptomatic and detected incidentally during abdominal ultrasound for some other purpose. They may mimick malignant neoplasm with their gross appearance and imaging modalities. So a diagnosis of serous papillary cystadenofibroma of ovary on frozen section can save the patient from unwanted extensive surgery. We here in discuss a case of serous papillary cystadenofibroma of ovary in a 45 year old multipara that was diagnosed initially on frozen section and later confirmed on histopathology, thus highlighting the role of frozen section in diagnosis of intraoperative ovarian neoplasms.
Primitive neuroectodermal tumor of kidney in elderly -A case series with review of literature
Authors: Kavitha K.P , Kottangal Gittwa Vatsaraj , Kollathodi Shehla Basheer , Kuruvila Shalini , Madhavan Lilly , Radhakrishnan Surdas
Published: September 2022

Primitive neuroectodermal tumor of the kidney (PNET) is a very rare and highly aggressive tumor commonly seen in young adolescents. These tumors are rare in patients over 40 years. Reports of renal PNET in elderly patients over 60 years are even rarer.

We report three cases of renal PNET in adult patients diagnosed over a period of three years. Among the three patients, two were above 60 years of age and the third patient was a 39-year-old male. All the three patients had extensive venous thrombosis at the time of presentation. One of the patients succumbed to death in the immediate post-operative period and the other two received chemotherapy.

Renal PNET owing to its rare occurrence in middle-aged and elderly poses a diagnostic challenge to the pathologist. The clinical and radiological findings have limitations in the accurate diagnosis. Thorough morphological evaluation along with immunohistochemistry and cytogenetic analysis help in arriving at a correct diagnosis. An accurate diagnosis is crucial for the initiation of proper treatment.
Independent Country Program Review Guyana 2017-2021
Authors: Arévalo Josette , Vera Priscila , De Santis Stefania ,   IDB Invest
Published: September 2022

This Independent Country Program Review (ICPR) covers the Bank's Country Strategy (EBP) of the Inter-American Development Bank (IDB) Group and the program in Guyana during the period 2017-2021. The ICPRs assess the relevance of the country strategy, provide aggregate information on the alignment and execution of the corresponding country program and, if the data allows it, its contribution to strategic objectives (SO) established in the country strategy. The ICPRs are primarily directed at the IDB Group's Boards of Executive Directors. They seek to provide the Boards with relevant information, which would otherwise not be available to them, for the analysis of the EBPs submitted for their consideration.
Pharmacological drug screening to inhibit uveal melanoma metastatic cells either via EGF-R, MAPK, mTOR or PI3K
Authors:   Department of Ophthalmology, University Hospital, LMU Munich, Munich 80336, Germany, Kassumeh Stefan , Kafka André ,   Department of Ophthalmology, University Hospital, LMU Munich, Munich 80336, Germany, Luft Nikolaus ,   Department of Ophthalmology, University Hospital, LMU Munich, Munich 80336, Germany, Priglinger Siegfried G. ,   Department of Ophthalmology, University Hospital, LMU Munich, Munich 80336, Germany, Wolf Armin ,   Department of Ophthalmology, University Hospital, University Ulm, Ulm 89075, Germany, Eibl-Lindner Kirsten ,   Department of Ophthalmology, University Hospital, LMU Munich, Munich 80336, Germany, Wertheimer Christian M. ,   Department of Ophthalmology, University Hospital, University Ulm, Ulm 89075, Germany
Published: September 2022

AIM: To screen five potential pharmacological substances specifically targeting EGF-R, MAPK, mTOR, or PI3K for their antiproliferative effects, possible impact on cell viability, as well as cell death rates on three different uveal melanoma metastasis cell lines in vitro.
METHODS: Three different uveal melanoma metastasis cell lines (OMM2.5, OMM2.3, and OMM1), that originated from human hepatic and subcutaneous metastasis, were exposed to inhibitors of different targets: erlotinib (EGF-R), everolimus (mTOR), selumetinib (MAPK), trametinib (MAPK) or the alkylphosphocholine erufosine (PI3K). Cell viability was assessed with a 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) dye reduction assay after 24h of treatment. Antiproliferative effects were evaluated separately after a 72-hour incubation of the cells with the pharmacological substance. Subsequently, the IC50 was calculated. Tumor cell death was investigated using a double stain apoptosis detection assay.
RESULTS: Selumetinib, trametinib, and erufosine significantly decreased cell viability of all OMM cell lines (P<0.04). In addition, selumetinib and trametinib showed a significant inhibition of cell proliferation (P<0.05). Everolimus and erlotinib solely inhibited cell proliferation at the used concentrations (P<0.05). Besides an increase of necrotic cells after erufosine treatment (P<0.001), no changes in the number of dead cells for the other substances were observed.
CONCLUSION: The preliminary drug screening demonstrates five new candidates, successfully targeting the canonical MAPK/ERK and PI3K/AKT/mTOR pathways in uveal melanoma metastasis cells in vitro. Hence, these findings provide an experimental basis to explore future single or combined therapy strategies for metastatic uveal melanoma.
Prophylaxis with intraocular pressure lowering medication and glaucomatous progression in patients receiving intravitreal anti-VEGF therapy
Authors:   New York Eye and Ear Infirmary of Mount Sinai, 310 East 14th Street, New York, NY 10003, USA, Du Jeanette , Cai Xiao-Yu ,   Department of Ophthalmology, University of Virginia School of Medicine, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908, USA, Prum Bruce E ,   Department of Ophthalmology, University of Virginia School of Medicine, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908, USA, Shildkrot Yevgeniy ,   Department of Ophthalmology, University of Virginia School of Medicine, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908, USA
Published: September 2022

AIM: To investigate whether pretreatment with pressure-lowering medication prior to anti-vascular endothelial factor (VEGF) injections had an effect on glaucomatous progression in patients with preexisting glaucoma or ocular hypertension (OHT).
METHODS: A total of 66 eyes from 54 patients with a preexisting diagnosis of glaucoma or OHT, treated with six or more anti-VEGF injections were selected for chart review. Primary outcome measures were rate of visual field loss in dB/year, rate of change in retinal nerve fiber layer (RNFL) thickness in microns/year, and need for additional glaucoma intervention.
RESULTS: The number of eyes requiring additional glaucoma medication was 5 of 20 (25.0%) and 14 of 46 (30.4%) for the pretreated and non-pretreated groups, respectively. The number of eyes requiring glaucoma laser or surgery was 4 of 20 (20.0%) and 13 of 46 (28.3%) for the pretreated and non-pretreated groups, respectively. Estimated mean rate of pattern standard deviation decline was not significant in either group (P>0.073), with no difference between groups (P=0.332). Although both groups showed significant RNFL change from baseline (P<0.011), no difference was detected between groups (P=0.467).
CONCLUSION: Pretreatment has no detectable effect on structural or functional glaucomatous progression. Patients receiving repeated injections may be at risk for glaucomatous complications requiring invasive intervention.
Association of sleep quality with myopia based on different genetic risk levels
Authors:   School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, He Juan , Chen Jie ,   The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Sun Bing ,   School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Wang Yan-Hui ,   School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Jiang Dan-Dan ,   The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Liu Lin-Jie ,   The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Lin Shu-Dan ,   School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Chen Yan-Yan ,   The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China
Published: September 2022

AIM: To analyse the association of sleep quality with myopia under different genetic risk (GR) levels.
METHODS: A cross-sectional survey of students aged 9-14y in Wenzhou, China, was conducted. Refraction without cycloplegia and ocular parameters were measured. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). Seventeen single nucleotide polymorphisms (SNPs) were replicated by association analysis and used to compute the GR score (GRS). Possible confounders were assessed by a questionnaire that collected information about the children and their parents. Generalized linear models were used to analyse the sleep quality, the GR, and their interaction effects on the risk of myopia.
RESULTS: Out of 1354 children included in this study, 353 (26.07%) had sleep disturbances. The GRS ranged from 4.49 to 12.89 with a mean of 7.74±1.23, and the participants were divided into a low GR group, a moderate GR group and a high GR group according to the GRS quartile. In the generalized linear model, the children with sleep disturbances and high GR had a higher risk of myopia than those without sleep disturbances and with low GR (OR=1.59, 95%CI: 1.12-2.25; OR=1.88, 95%CI: 1.23-2.88, respectively). Compared to those with low GR and SDs, children with high GR with or without SDs had a higher risk of myopia (OR=4.88, 95%CI: 2.03-11.71; OR=1.70, 95%CI: 1.06-2.72, respectively).
CONCLUSION: The prevalence of sleep disturbances in elementary school students in Wenzhou was 26.07%. There is a significant interaction between sleep disturbances and a high GR of myopia, suggesting that a high GR of myopia may increase children's sensitivity to sleep disturbances. This study indicates that children with a high GR of myopia need to achieve adequate sleep duration and excellent sleep quality.
Percepción sobre uso de Fisiología en el Proceso Enfermero
Authors: Bianchi Maria Eugenia
Published: September 2022

Introducción: el ejercicio de la enfermería requiere conocimiento integral del funcionamiento del cuerpo humano, por lo cual es imprescindible el aprendizaje de fisiología humana dentro del proceso formativo de grado. El proceso enfermero, herramienta para la práctica profesional sistemática, dinámica y oportuna basado en el método científico, constituye el eje organizador del currículo de la Licenciatura en Enfermería en la Universidad Nacional del Nordeste (Corrientes, Argentina). Objetivo: Identificar la percepción que estudiantes y docentes de asignaturas troncales de Enfermería tenían sobre la aplicación o no de conocimientos fisiológicos desarrollados en los trabajos prácticos de la asignatura Fisiología en las distintas etapas del proceso enfermero. Metodología:  Se realizó un estudio descriptivo, observacional y transversal, cuestionario anónimo distribuido al azar a estudiantes y docentes, consistente en una tabla de doble entrada que describe los contenidos de cada trabajo práctico, por un lado, y las fases del proceso enfermero, por el otro. Resultados: respondieron 24 docentes (39 %) y 38 estudiantes (61 %). Las fases en que más reconocieron aplicar conocimientos de fisiología en el proceso enfermero fueron, en ambos grupos, valoración y diagnóstico; en cada trabajo práctico fue percibido diferente por docentes y estudiantes, siendo mayor el reconocimiento del uso de fisiología en el proceso enfermero por parte de docentes. Conclusiones: vertebrar la actividad práctica de fisiología alrededor del proceso enfermero parece constituir una estrategia didáctica válida, dado que docentes y estudiantes perciben, en mayor o menor medida, que aplican conocimientos trabajados en la asignatura en las distintas etapas del proceso enfermero, particularmente en la valoración y el diagnóstico. La percepción fue mayor en docentes, lo cual evidencia mejor manejo del proceso enfermero, por tener mayor nivel de conocimientos y práctica profesional.
Imaging Features of Dyke-Davidoff-Masson Syndrome
Authors: AlHatmi Asma , Almashaikhi Talal , Al Ajmi Eiman
Published: September 2022

NONE
Effect of Erector Spinae Block and PECS Block on Quality of Recovery and Analgesia After Modified Radical Mastectomy
Authors: Mohsin Md Hammad , . Hemlata , Verma Reetu , Singh Dinesh , Singh Sarita , Singh Kulranjan
Published: September 2022

Objectives: Postoperative pain after modified radical mastectomy ranges from moderate to severe. Pectoralis block in comparison to Erector Spinae block have been found better in reducing pain scores and reducing consumption of rescue analgesic in postoperative period. This study aimed to compare the effect of Erector Spinae block and Pectoralis block on quality of recovery after Modified Radical Mastectomy using QoR-40 score. Methods: After general anaesthesia, patients were given block according to computer generated randomization. Group-I-Pectoralis block including PEC I AND PEC II(PECS), Group-II-Erector spinae block(ESP) and Group III-Control Group (No intervention). Quality of recovery (QoR-40) score was observed on morning of surgery and at 24 hrs. Time to rescue analgesia and total consumption of rescue analgesia in first 24 hrs. were also observed. Results: In the postoperative period at 24 hrs. Global QoR-40 scores were 183.64±6.36 in PECS group, 179.68± 6.38 in ESP group and 171.37±6.88 in control group. (p<0.0001) But, there was no statistically significant difference between QoR score of PECS & ESP group patients(p=0.0551). The total requirement of rescue analgesic was significantly lesser in PECS group (137.28±31.46 mg) in comparison to ESP Group(189.46±42.98mg) and control group (229.57±46.80 mg). (p<0.0001). Time to first rescue analgesia was significantly higher in PECS group (6.53±2.78 hrs) in comparison to ESP (4.05±2.91 hrs) and control group (2.15±1.51 hrs). (p<0.0001) Conclusion: Both Erector Spinae block and Pectoralis block are effective for improving QoR score and reducing consumption of rescue analgesic after modified radical mastectomy.

Keywords: breast surgery, cancer, postoperative recovery, postoperative pain
Wspomnienia ze szpitala psychiatrycznego – między prawem a medycyną
Authors: Kmieciak Błażej
Published: September 2022

Psychiatric hospital is a special place. On the one hand, the hospital is interested and fascinated researchers who want to understand the nature of the human psyche. On the other prospects similar facilities still inspire social fear. Psychosis, treatment coercion or incapacitation are terms which are often presented in the context of scandals, violations or concerns. Following the global and national literature there are publications that show from inside the lives of patients psychiatric hospital. These are not only a scientific publications, such as the famous “Total institutions”, written by E. Goffman. On similar topics have spoken out also contemporaries: foreign writers, scientists and national experts dealing with assistance to the mentally ill. The present article aims to present-hospital perspective shown in the diaries and memoirs. In particular, the analysis will undergo a diary of Brazilian writer Paulo Coelho. It was written by him during his first psychiatric hospitalization. The work will be undertaken particularly attempt to draw attention to “legal-creative” character of similar publications.
Odwzorowując autobiografię w sąsiedztwie biofikcji. O literackich kontekstach „Kronosu” Witolda Gombrowicza jako zapisków intymnych
Authors: Czerwiński Marcin
Published: September 2022

Author in his article analyzes “Kronos”: intimate notes by writer Witold Gombrowicz. Author investigates its language, subject matter and very important literary context of these notes. This context is constituted by famous literary “Diary” by the same writer, in which fictional components play a vital role. In the article there is considered the system of these both written works and it is interpreted as the writer’s intentional antropological project. In this system both texts take up opositional, bipolar places – the first one makes his way towards fiction, the second one – towards autobiographical reality. Author of article points out too that some artificial conventions (less or more adequate) in the area of literature have been established many times in its history in objective to convey empirical reality in the best way possible. These coventions have of necessity literary character. This being the case we can notice literary techniques even in so radically mimetic text as “Kronos”. They are borrowed from literature or they are artistic, linguistic representation of empirical reality. In this meaning intimate notes, of this kind as Gombrowicz’s “Kronos”, they have fictional structure. Besides author of article expresses a view that even the most reference story, in its narrative aspect, must have signs of fiction. Therefore the article shows two sides of specific polarity of “Kronos”: its direction into “mimesis” and facts and its involving in a fiction and literature.
Internetowa porada językowa – próba socjolingwistycznej analizy gatunku
Authors: Ginter Joanna
Published: September 2022

The article presents the Internet language advice (published on the websites) as a linguistic genre. It is a new mutation of the language advice – a genre known for years. The analysis of the Internet language advice model includes: the theme, the composition (obligatory and optional components), the style (with the concept of secondary orality) and sender-receiver relations. In the summary there are listed the most important features of the Internet language advice: formality, dialogism, metalinguistic approach to the subject, popular science style, cognitive (referential) and impressive function.
Legenda literacka jako przedmiot badań socjologii na przykładzie legendy Stanisława Przybyszewskiego
Authors: Żurko Jerzy
Published: September 2022

This article addresses the question whether literary legend may be the subject of sociological research? The Revolution structuralist literary resigned from the study of literary legend. The study of literary legend is not the study of literary works. This involves the study of social, cultural, biographical writer living conditions. It follows from this that the legend literary may be the subject of sociological research (sociology of culture). It was presented the theoretical concept of the functioning of literary legend, written by Andrew Z. Makowiecki. He writes about the conditions of the uprising, the existence of a literary legend. It answers the question: What are the features of literary legend in relation to the reception work of the writer.
Taxonomy and Prevalence of Hard Tick Species on Small Ruminants (Goats and Sheep) in Pakistan
Authors:   Department of Clinical Medicine and Surgery, Faculty of Veterinary Sciences, University of Agriculture Faisalabad, Pakistan, Riaz Muhammad Nouman
Published: September 2022

Ticks are very dangerous ectoparasites of large and small domestic and wild animals throughout the globe. Tick infestation is the most serious threat to animal health, resulting in significant economic losses in many countries. The current research work was planned to collect, and identify the tick species found on goats and sheep. Four tick species i.e. Hyalomma anatolicum, Hyalomma dromedarii, Dermacentor marginatus and Haemaphysalis punctata were identified. Prevalence rate wise data showed Hyalomma anatolicum (60.50%) followed by Hy. dromedarii (15.50%), Dermacentor marginatus (13.00%) and Haemaphysalis punctata (11.00%). Sex wise data showed that female hosts were more loaded with ticks than male, and young carried more ticks than old. Highest infestation was recorded on goats than sheep. The current study concluded that Hyalomma spp. are widely distributed and need to control them in the whole country especially study area.
Developmental Outcomes of Anganwadi Children in Tribal Areas of Visakhapatnam District
Authors:   College of Community Science, Acharya N.G. Ranga Agricultural University, Lam, Guntur, Kumari Mosya Aruna
Published: September 2022

The study aimed to assess the developmental outcomes of Anganwadi children in tribal areas of Visakhapatnam district. The sample consists of 120 Anganwadi children were selected from thirty Anganwadi centres. From each Anganwadi centre, four boys and four girls in the age group of 3-6 years were randomly selected. The findings revealed that most of the Anganwadi children were in the age group of 4 - 6 years and maximum percentages (42%) of children were found in the class of UKG (Upper Kindergarten). The majority of the children (67%) belong to the nuclear type family. More than half (65.9%) of the children are able to complete the task on overall developmental outcomes of children based on child assessment cards (3-6 years). Boys and girls performed almost equally in all areas of development. Girls performed better than boys in the area of physical (40%), cognitive (12.5%), socio-emotional development (39.1%) and creativity (36.7 %). Boys performed better than girls in the area of language development (20 %) only. The present study's findings showed a gap in the implementation of the preschool curriculum by Anganwadi workers based on their knowledge levels of curriculum and children's developmental outcomes. Hence measures should be taken by the Integrated Child Development Service (ICDS) to improve the implementation status of preschool curriculum by Anganwadi workers. Majorly, more focus should be provided on preschool education (PSE) programmes along with other services such as nutrition, growth monitoring, referral services, parent education programme and health services provided at Anganwadi centres. As the Anganwadi workers have more additional workloads, it is difficult for them to focus on the implementation of the curriculum. So, one more helper can be recruited by the government to carry out additional duties of the Anganwadi worker. More preschool education training or Early Childhood Care & Education (ECCE) training should be conducted to enhance the growth & developmental need of children in an effective manner.
​Foods for Specific Health Use (FOSHU): A Review
Authors: Singla Priya , Dhillon Piverjeet Kaur , . Madhu
Published: September 2022

Adequate nutrient intake (avoidance of excess or deficiency) is essential to ensure an optimum health status hence, no induction of risks related to lifestyle diseases. Even nutrients and functional ingredients in foods are chemical substances but we need to draw a line of demarcation between such substances, based on long history of dietary habits and novel substances and/or xenobiotics. FOSHU contains highly purified or concentrated functional ingredients, present in ordinary foods,however, it is to take safety issues into consideration. FOSHU is the only type of food product, with functional ingredients, can carry health claims and affect the structure and physiological functions of the body. These consumed for health promotion or to control specified health conditions such as gastrointestinal conditions Therefore, FOSHU products target both healthy individuals and diseased people. When the products are manufactured or distributed, the government approval is required with prior hand rigorous evaluation of safety and effectiveness of proposed product. In a nutshell, comprehensive knowledge on structure and function of human body, pathogenesis of diseases, nutrients and their metabolism etc., as well as the mechanisms of efficacy vis-à-vis FOSHU, which ranges over pharmacology, medicine and food and nutrition, is required.
Transformasi Digital Dan Peningkatan Kesejahteraan Masyarakat Pedesaan Kawasan Pegunungan Ijen Banyuwangi
Authors:   Community Development Study Program, the Graduate School, IPB University Bogor, Indonesia, M.Mazya Thita , M. Kolopaking Lala ,   Department of Communication Science and Community Development, Faculty of Human Ecology, IPB University Bogor, Indonesia, Satria Arif ,   Department of Communication Science and Community Development, Faculty of Human Ecology, IPB University Bogor, Indonesia, R. Nurrochmat Dodik ,   Department of Forest Management, Faculty of Forestry and Environment, IPB University Bogor, Indonesia, Irwan Irwan ,   Universitas PGRI Sumatera Barat, Jl. Gn. Pangilun, Gn. Pangilun, Kec. Padang Utara, Kota Padang, Sumatera Barat 25111, Indonesia
Published: September 2022

The entry of digital technology into Banyuwangi's Ijen Crater Nature Park has resulted in numerous changes. Digital Technology or, information and communication technologies, have the potential to improve rural welfare. Rural ICTs, however, necessitates special efforts to develop suitable means for those who are unable to access the Internet or do not have the language capacity to understand the content. The aims of this study are to determine the extent to which digital technology penetration can promote transformation and improve the rural’s welfare. To assess the transformation and the level of welfare, a qualitative survey and analysis were conducted using 120 respondents household survey data . The findings show that villages have been able to reduce the digital divide and improve their quality of life, with a long-term positive impact on material well-being. This study demonstrates how digital technology can serve as a new source of social capital for rural sustainable developmen.
Produktivitas Usahatani Dan Sistem Pemasaran Umbi Taka (Tacca Leontopetaloides) Di Kabupaten Garut
Authors:   Research Center for Ecology and Ethnobiology, National Research and Innovation  Agency, Bogor, Indonesia, Suhartono Suhartono , Fauziyah Eva ,   Research Center for Population, National Research and Innovation Agency, Jakarta, Indonesia
Published: September 2022

Taka tuber is a coastal plant type that can be an alternative food source, but its use is still limited until now. This study aims to determine the productivity and marketing system of taka farming on farmer scale. Respondents were chosen deliberately, namely farmers who had or are currently cultivating taka of 16 respondents. Data were analyzed descriptively by calculating farm revenue, cost and income, farm, labour, and capital productivity. The results showed that taka farming in Cikelet District was not yet efficient. Taka farming, which is sold in the form of tuber is not less profitable then selling flour. Sales in the form of flour produce and cultivate without fertilizer has a ratio of income and costs (R/C) of 1.05 (feasible), work productivity (IDR65,217/HOK) is higher than the standard wages of farm labourers in that area (IDR60,000/HOK). It has capital productivity is 5.04% higher than interest on deposits in banks 0.25-4.45% per year. The taka marketing has been running locally with a fairly short marketing channel from farmers directly to flour makers (tubber) or consumers (flour).
Physical Activity During the COVID-19 Pandemic in the UK: A Qualitative Analysis of Free-Text Survey Data
Authors: Hailey Verity , Burton Alexandra , Hamer Mark , Fancourt Daisy , Fisher Abigail
Published: September 2022

Background Several quantitative studies have found a decline in physical activity in response to COVID-19 pandemic restrictions. The aim of the present study was to use large-scale free text survey data to qualitatively gain a more in-depth understanding of the impact of the COVID-19 pandemic on physical activity, then map barriers and facilitators to the Capability, Opportunity, Motivation, and Behaviour (COM-B) Model of Behaviour to aid future intervention development. Methods 17,082 participants provided a response to the free text module, and data from those who mentioned physical activity in any context were included. Data were analysed using thematic analysis and key themes identified. Results 5396 participants provided 7490 quotes related to physical activity. The sample were predominately female (84%), white (97%) and aged <60 years (57%). Seven key themes were identified: the importance of outdoor space, changes in daily routine, impact of COVID-19 restrictions, perceived risks or threats to participation, the importance of physical health, the importance of physical activity for mental health and the use of technology. Conclusion Future physical activity interventions could encourage people to walk outdoors, which is low cost, flexible, and accessible to many. Developing online resources to promote and support physical activity provides a flexible way to deliver quality content to a large audience.
Maternal Satisfaction towards Childhood vaccine Services and its Associated Factors among Children Caregivers, in a Public Health Facility at Gondar town, Northwest Ethiopia, 2022
Authors: Zeleke Agerie Mengistie , Beley Worku Chechol , Asres Getaw Wubie
Published: September 2022

Background: Immunization prevents over 4-6 million deaths each year worldwide. Ensuring mother satisfaction is an important means of preventing the death of children caused by communicable diseases. However, in Ethiopia, there is paucity of evidence on maternal satisfaction with immunization services. Thus, this study is aimed at assessing the level of maternal satisfaction with childhood immunization services and associated factors among children’s caregivers. Methods: A facility-based cross-sectional study was conducted among 556 systematically selected children’s caregivers in public health facilities at Gondar Town from May through June, 2022. Data were collected using a pretested structured questionnaire. P≤ 0.25 during the bivariate binary logistic regression analysis was included in the multivariate analysis. From the multivariable analysis, variables with p ≤ 0.05 were declared statistically significant. Results: The prevalence of maternal satisfaction towards childhood immunization services was 69.3%(95%CI: 65.5, 73.1%). Of mothers, 45.3% had adequate knowledge, while 43.9% had favorable attitude. Mothers 19-24 years old [AOR = 5.29; 95%CI:2.58,10.86], mothers who waited less than one hour [AOR = 3.03; 95%CI: 1.92,4.77], mothers less than thirty minutes waiting in health facility[AOR=1.98;95%CI:1.24,3.15], mother feel happy during service[ AOR=4.00; 95%CI: 2.53,6.34], mothers adequate knowledge [AOR=2.91; 95%CI: 1.79, 4.73] and had favorable attitude [AOR=3.64; 95%CI: 2.25, 5.91] were significantly associated with maternal satisfaction during childhood immunization services.Conclusions: The overall level of mothers’ satisfaction with childhood immunization services was considerably lower as compared with other studies. Thus, the town health office and concerned stakeholders need more efforts to improve mothers’ satisfaction with childhood immunization services.
Association of Multidrug Resistance Bacteria and Clinical Outcomes of Adult Patients with Sepsis in the Intensive Care Unit
Authors: Al-Sunaidar Khalid Ahmad , Aziz Noorizan Abd , Hassan Yahaya , Jamshed Shazia , Sekar Mahendran
Published: September 2022

Background: Multi-drug resistance organisms (MDRO) often cause increased morbidity, mortality, and length of stays (LOS). However, there is uncertainty whether the infection of MDRO increase the morbidity, mortality, and ICU-LOS. Objective: This study performed to determine the prevalence of MDRO in ICU, site of infection and the association of MDRO or site of infection with mortality. Secondary outcome was determined by ascertaining the association of MDRO or site of infection with (ICU-LOS). Methods: A retrospective cohort study was performed with adult sepsis patients in ICU. Univariate and multivariate (MVA) logistic regression with cox regression modeling were performed to compute the association of MDRO on ICU-mortality. MVA modelling was performed for ICU-LOS predictors. Results: Out of 228 patients, the isolated MDRO was 97 (42.5%) of which 78% were gram-negative bacteria. The mortality rate among those with MDRO was 85 (37.3%). The hospital acquired infection (HAI) was significantly predictor for ICU-LOS in univariate linear regression (R² = 0.034, P=0.005). In MVA linear regression, both Enterococcus faecalis infection and acinetobacter baumannii (AC) -MDRO were predictors for ICU-LOS with (R² = 0.478, P<0.05). In the univariate cox regression, only the infection with AC- MDRO was a risk factor for ICU-mortality with [ HR =1.802 (95% CI: 1.2 – 2.706; P = 0.005)]. Conclusions: Identifying risk factors for MDRO highlight the appropriate administration of empirical antibiotics and effectively control of source of infection which would reduce mortality and ICU-LOS. The usage of broad- spectrum antibiotics should be limited for those having substantial risk factors to acquire MDRO.
Coumarin-induced Hepatotoxicity: A Narrative Review
Authors: Pitaro Michele , Croce Nicoletta , Gallo Valentina , Arienzo Alyexandra , Salvatore Giulia , Antonini Giovanni
Published: September 2022

Coumarin is an effective treatment for primary lymphoedema, as well as lymphoedema related to breast cancer radiotherapy or surgery. However, its clinical use is limited in several countries due to the possible occurrence of hepatotoxicity, mainly in the form of mild to moderate transaminase elevation. Noteworthy, only few cases of severe hepatotoxicity have been described in literature, with no reported cases of liver failure. Data available on coumarin absorption, distribution, metabolism and excretion have been reviewed, focusing on hepatotoxicity studies carried out in vitro and in vivo. Finally, safety and tolerability data from clinical trials have been thoroughly discussed. On the basis of these data, coumarin-induced hepatotoxicity seems to be restricted to a small subset of patients, probably due to the expression of specific alleles of CYP450 isoform not yet well characterized. In summary, more research is needed in order to identify patients at risk of developing hepatotoxicity following coumarin treatment, in order to improve the risk/benefit ratio of the product and allow more patients to benefit from its therapeutic properties.
Probiotic Rosé Wine Made with Saccharomyces Cerevisiae var. Boulardii
Authors: Mulero-Cerezo Joaquín , Tuñón-Molina Alberto , Cano-Vicent Alba , Pérez-Colomer Lorena , Martí Miguel , Serrano-Aroca Ángel
Published: September 2022

This paper reports for the first time on the production of probiotic alcoholic and non-alcoholic rosé wines with enhanced health benefits made with Saccharomyces cerevisiae var. boulardii probiotic yeast. The alcohol, sugar, volatile acidity lactic and malic acid contents were assessed for S. cerevisiae var. boulardii before and after fermentation and distillation and compared with a conventional Saccharomyces cerevisiae (ex-bayanus) yeast. The free amino nitrogen and gluconic acid concentrations in the musts were determined. Yeast viability was evaluated after fermentation and distillation as a function of time (0, 15 days, 3 months and 6 months) both at room temperature (25±0.5ºC) and refrigerator temperature (4±0.5ºC). The results obtained showed that the probiotic rosé wine produced with S. cerevisiae var. boulardii possesses the typical values and sensory attributes of other commercial wines produced with S. cerevisiae (ex-bayanus). The probiotic S. cerevisiae var. boulardii yeast survives the high alcohol content produced during fermentation and vacuum distillation. The study also showed that this probiotic rosé wine stored either at room temperature or in a refrigerator keeps its probiotic viability for at least six months, which makes it a promising for large-scale production, in which long storage times are required by both producers and consumers.
Elemental Laser-Plasma Analysis of Pointed Gourd Leaves for Diabetes Management
Authors: Kumar Tejmani , Rai Prashant K , Rai Abhishek K , Rai Nilesh K , Rai Awadhesh K , Parigger Christian , Watal Geeta , Yadav Suman
Published: September 2022

This interdisciplinary work communicates identification and quantification of elements responsible for the bioactive potency of leaves from pointed gourd, trichosanthes dioica,using laser induced breakdown spectroscopy (LIBS). Calibration-free LIBS determines the presence of various trace and major elements, their concentrations, and ratios in which they are present in the leaves. The presence of specific elemental ratios of magnesium/sodium and magnesium/potassium could be promising for managing diabetes mellitus. Variable doses of 500, 750, 1000, and 1250 mg per kg body weight of aqueous extract from trichosanthes dioica leaves are administered. A dose of 1000 mg per kg body weight is found to be the most effective. Based on encouraging results, the extract could be harvested to serve as anti-diabetic medication for diabetes and associated symptoms.
Politik, Ekonomik ve Finansal Risklerin Doğrudan Yabancı Yatırımlar Üzerindeki Etkisi: Türkiye Örneği
Authors: YILDIZ Bülent , ŞANLI Orhan
Published: September 2022

Bu çalışmada, Türkiye için politik, ekonomik ve finansal risklerin doğrudan yabancı yatırımlar (DYY) üzerindeki etkisi ARDL sınır testi yaklaşımı kullanılarak analiz edilmiştir. Aylık verilerin kullanıldığı analiz 1992:M1-2016:M12 dönemini kapsamaktadır. Çalışmanın sonuçlarına göre, uzun dönemde düşük politik ve ekonomik riskin (politik ve ekonomik istikrarın) DYY üzerinde pozitif bir etkiye sahip olduğu tespit edilmiştir. Kısa dönem sonuçlarına göre ise finansal istikrar DYY’yi pozitif yönde etkilerken, politik ve ekonomik istikrar, beklentilerin aksine, DYY’yi negatif yönde etkilemektedir. Bu sonuçlar politik, ekonomik ve finansal istikrarın Türkiye örneğinde doğrudan yabancı yatırım girişlerini güçlü bir şekilde etkilediğini göstermektedir.
A Case Report of a Novel Atypical Mycobacterial Infection
Authors: McLaughlin C.M. , Schade M. , Cochran E. , Taylor K.F.
Published: September 2022

Case:

A 76-year-old fisherman with a history of diabetes mellitus, coronary artery bypass grafting, and a previous ipsilateral elbow wound presented with a 1-year history of hand pain and swelling. Anti-inflammatories and antibiotics were administered without improvement. Magnetic resonance imaging and ultrasound demonstrated flexor tenosynovitis. Intraoperative cultures revealed Mycobacterium chimaera. The treatment course included 2 tenosynovectomies and a 1-year course of triple antimycobacterial therapy.

Conclusion:

Nontuberculous mycobacteria infections should be considered in cases of indolent tenosynovitis. M. chimaera should be considered in patients with a history of cardiopulmonary bypass given its association with cardiopulmonary heater-cooler units.
Interprosthetic Femur Fractures
Authors: McMellen Christopher J. , Romeo Nicholas M.
Published: September 2022

» The prevalence of interprosthetic femur fractures (IFFs) is rising with the aging population and increased prevalence of total joint arthroplasty.

» IFFs have high rates of complications and high associated morbidity and mortality.

» The main treatment methods available for IFFs include plate fixation, intramedullary nailing, combined plate fixation and intramedullary nailing, and revision arthroplasty including partial and total femur replacement.

» There have been several proposed classification systems and at least 1 proposed treatment algorithm for IFFs; however, there is no consensus.

» Whichever treatment option is chosen, goals of surgery should include preservation of blood supply, restoration of length, alignment, rotation, and sufficient stabilization to allow for early mobilization.
Ship Simulator of the Future in virtual reality
Authors: Ervin Kelly , Smink Karl , Vu Bryan , Boone Jonathan
Published: September 2022

The Army’s modernization priorities include the development of augmented reality and virtual reality (AR/VR) simulations for enabling the regiment and increasing soldier readiness. The use of AR/VR technology at the U.S. Army Engineer Research and Development Center (ERDC) is also growing in the realm of military and civil works program missions. The ERDC Coastal and Hydraulics Laboratory (CHL) has developed a ship simulator to evaluate bay channels across the world; however, the current simulator has little to no physical realism in nearshore coastal regions (Figure 1). Thus, the ERDC team is researching opportunities to advance ship simulation to deliver the Ship Simulator of the Future (SSoF). The SSoF will be equipped with a VR mode and will more accurately resolve nearshore wave phenomena by ingesting precalculated output from a Boussinesq-type wave model. This initial prototype of the SSoF application is intended for research and development purposes; however, the technologies employed will be applicable to other disciplines and project scopes, including the Synthetic Training Environment (STE) and ship and coastal structure design in future versions.
Scale-Invariant Feature Transform Algorithm with Fast Approximate Nearest Neighbor
Authors: Gbash Ekhlas Khalaf , Saleh Suha Mohammed
Published: September 2022

There is a great deal of systems dealing with image processing that are being used and developed on a daily basis. Those systems need the deployment of some basic operations such as detecting the Regions of Interest and matching those regions, in addition to the description of their properties. Those operations play a significant role in decision making which is necessary for the next operations depending on the assigned task.
In order to accomplish those tasks, various algorithms have been introduced throughout years. One of the most popular algorithms is the Scale Invariant Feature Transform (SIFT). The efficiency of this algorithm is its performance in the process of detection and property description, and that is due to the fact that it operates on a big number of key-points, the only drawback it has is that it is rather time consuming.
In the suggested approach, the system deploys SIFT to perform its basic tasks of matching and description is focused on minimizing the number of key-points which is performed via applying Fast Approximate Nearest Neighbor algorithm, which will reduce the redundancy of matching leading to speeding up the process.
The proposed application has been evaluated in terms of two criteria which are time and accuracy, and has accomplished a percentage of accuracy of up to 100%, in addition to speeding up the processes of matching and description.