bluuebunny/crossref_metadata_2025 huggingface dataset:
#011 Diagnóstico diferencial de lesão óssea mandibular
Authors:   Faculdade de Medicina Dentária da Universidade de Lisboa, Lourenço Fábio , Olazábal Cayetana ,   Faculdade de Medicina Dentária da Universidade de Lisboa, Freitas Filipe ,   Faculdade de Medicina Dentária da Universidade de Lisboa, Moreira André ,   Faculdade de Medicina Dentária da Universidade de Lisboa, Francisco Helena ,   Faculdade de Medicina Dentária da Universidade de Lisboa, Caramês João ,   Faculdade de Medicina Dentária da Universidade de Lisboa
Published: January 2025

Introdução: A Organização Mundial de Saúde publicou
a mais recente classificação dos tumores da cabeça e pescoço (5ª edição, 2024). Os ossos maxilares apresentam, frequentemente, patologia de natureza quística ou tumoral,
traduzindo-se como lesões osteolíticas, osteocondensantes
ou mistas, que se associam a diferentes etiologias - inflamatórias, infeciosas ou neoplásicas. O diagnóstico definitivo pode ser desafiante, exigindo a integração de caraterísticas clínicas, imagiológicas e histológicas. O diagnóstico
diferencial de pequenas lesões radiopacas não odontogénicas deve incluir o osteoma e a osteosclerose idiopática. O
osteoma consiste numa neoplasia benigna composta por
osso maduro, compacto ou esponjoso, de crescimento lento.
A osteoesclerose idiopática trata-se de uma lesão reativa,
de origem desconhecida, muitas vezes, um achado radiológico em exames de rotina. Descrição do Caso Clínico: Doente do sexo feminino, 71 anos, referenciada a consulta de
Cirurgia e Medicina oral da FMDUL para avaliação de lesão
óssea mandibular identificada em ortopantomografia de
rotina, mantida sob vigilância nos últimos 8 anos. Diagnosticada com hipotiroidismo e hipertensão arterial, medicada
diariamente com Levotiroxina (50 mg) e associação de Lisinopril/Amlodipina (20mg 5mg). Afirma intolerância ao glúten e nega alergias medicamentosas, hábitos tabágicos ou
alcoólicos. O exame objetivo não revela alteração patológica da mucosa oral, não havendo sintomatologia dolorosa
espontânea ou à palpação. Na última ortopantomografia
documenta-se aumento da dimensão e radiopacidade da
lesão intraóssea. Foi prescrita tomografia computorizada de
feixes cónicos que confirmou a presença de lesão hiperdensa, grosseiramente circular, de limites bem definidos e,
aproximadamente, 1 cm de diâmetro, junto à região apical
do dente 45. Realizou-se uma biópsia incisional, cujo exame
anatomopatológico excluiu a presença de osteoma, corroborando o diagnóstico inicial de osteosclerose idiopática.
Ausência de indicação para excisão completa da lesão assintomática. Discussão e Conclusões: A interpretação de
lesões ósseas craniofaciais é complexa devido à semelhança clínica e imagiológica de muitas entidades. A avaliação
histopatológica pode ser fundamental para a distinção entre lesões de natureza reativa e neoplásica. O médico dentista desempenha um papel crucial no correto diagnóstico
das alterações patológicas dos maxilares, devendo estar
familiarizado com as entidades mais comuns.
Accuracy of PECARN head CT guidelines in predicting positive findings on CT of the head of patients after mild head injury in a large trauma center in Saudi Arabia
Authors: Meriky Lama , Basehi Ahmed , Almohiy Nadiyah , Alghamdi Abdulaziz , Altayim Hani , Alshehri Zainah , Alenezy Njoud , Alenezi Khaled
Published: January 2025

Objective: This study aimed to evaluate the diagnostic performance of the pediatric emergency care applied research network (PECARN) head computed tomography (CT) rule in a pediatric emergency department in a large trauma center in Riyadh, Saudi Arabia.
Methodology: This retrospective qualitative cross-sectional study reviewed the records of pediatric patients with minor head injuries (MHIs) who presented to the emergency department at King Abdullah Specialized Children's Hospital. Patients who underwent head CT scans were included, with minor head injury defined by a Glasgow coma scale score of 14-15. The study population was divided into two age groups: below 2 years and 2 years and above. The PECARN criteria were retrospectively applied to determine the justification for head CTs. Data on demographic, clinical, and radiological profiles were collected.
Results: A total of 1,132 pediatric patients were included, with 372 under 2 years of age and 760 aged 2 years and above. Overall, 38.8% of the patients had positive CT findings, while 60.2% had negative findings. According to the PECARN criteria, 4.9% of the cases met the criteria for head CT. The PECARN rule demonstrated a sensitivity of 9.2%, a specificity of 97.9%, a positive predictive value (PPV) of 74.5%, and a negative predictive value of 62.2%.
Conclusion: The PECARN head CT rule showed high specificity and PPV, supporting its effectiveness in identifying pediatric patients with MHIs who do not require CT scans, thus minimizing unnecessary radiation exposure. However, the significant proportion of unjustified CTs highlighted the need for better adherence to the PECARN criteria in clinical practice. Enhancing physician education and improving clinical documentation might optimize the use of the PECARN rule and improve patient care in pediatric emergency settings.
Effects of Endogenous Bioregulators from Mammalian Blood Serum and Bone Tissue on Amphibian Limb Regeneration
Authors:   Nesmeyanov Institute Of Organoelement Compounds, Russian Academy Of Sciences, Moscow, Russian Federation
Published: January 2025

The effects of bioregulators purified from mammalian blood serum and bone tissue on amphibian limb regeneration have been studied. The bioregulators from blood serum at a high concentration (10-1 mg/mL) has a strong morphogenetic effect on Xenopus laevis limb regeneration following amputation through the proximal part
A Brief Introduction to Adventitious Shoot Regeneration in Plants
Authors:   Beijing Academy Of Forestry And Pomology Sciences, Beijing Academy Of Agriculture And Forestry Sciences, Beijing, China
Published: January 2025

The establishment of plant adventitious shoot regeneration systems mainly has two intentions. On the one hand, an adventitious shoot regeneration system provides technology of the rapid reproduction of plants. On the other hand, they are basis of gene function research in plants. Adventitious shoots regeneration of plants is affected by internal signals and external conditions.
A New Adapted Machine to Simulate Narghile Smoke
Authors:   University Of Itajaí Valley, Santa Catarina, Brazil
Published: January 2025

As only few studies, to date, have reported new methodologies to simulate the flow of human puff topography during the use of water-pipes, we present - based on an existing machine produced with a high financial investment - a new low-cost simplified device to submit mice to water-pipe smoke, supporting the accomplishment of new scientific research with affordable costs.
Implementing a Walking Program for Sedentary Patients in a Weight Management Clinic: Review of Literature
Authors:   South Dakota State University, United States
Published: January 2025

A sedentary life is defined as consistent physical inactivity. To encourage sedentary patients to adopt active lifestyles, structured exercise programs activate healthier living.
Implementing a Walking Program for Sedentary Patients in a Weight Management Clinic: Methodology
Authors:   1 South Dakota State University, United states
Published: January 2025

Promoting physical activity in weight management patients promotes better patient outcomes.
Pengaruh Ukuran Perusahaan, Kepemilikan Institusional dan Leverage terhadap Pengungkapan Emisi Karbon
Authors: Rosita Vivi Mella , Purnamawati Indah , Mulyono Resha Dwi Ayu Pangesti
Published: January 2025

Unpredictable global warming is still an environmental issue that is often discussed in most countries including Indonesia. Companies must voluntarily disclose carbon emissions in order to gain the trust of investors and potential investors and increase company profits. This study aims to test and analyze the effect of company size, institutional ownership, and leverage on carbon emission disclosure in energy sector and industrial sector companies listed on the Indonesia Stock Exchange in 2020-2022. The sample consisted of 42 companies using a purposive sampling method, while the data analysis method used multiple linear regression analysis. The results showed that company size has a significant positive effect on carbon emission disclosure, while institutional ownership and leverage have no effect on carbon emission disclosure.
Determinan Perubahan Struktur Modal pada Usaha Mikro Kecil dan Menengah
Authors: Permana Gusi Putu Lestara , Endita Ni Kadek Citra , Dewi Putu Purnama , P Kadek Wulandari Laksmi
Published: January 2025

This study emphasizes the importance of broader access to financial services, the use of evolving financial technology, and financial literacy in capital structure decision-making for MSMEs. The study examined 75,620 SME units using the pecking order theory and resource-based view theory, selecting 75 responders using the Hair formula. The data analysis used SPSS software for classical assumption tests, multiple linear regression analysis, coefficient of determination tests, and partial t-tests. Results show that financial inclusion, technology, and literacy positively and significantly affect capital structure decisions. These three independent factors explain 53.8% of capital structure decisions. Thus, the pecking order theory and resource-based view theory help Gianyar Regency SMEs make capital structure decisions. The study emphasizes the importance of broader access to financial services, the use of emerging financial technology, and financial literacy in making capital structure decisions for MSMEs
Evaluasi Kewajiban Perpajakan Bendahara Universitas Papua Atas Pemotongan/Pemungutan PPh Atas Belanja Modal Tahun 2023
Authors: Nurrohman Pungkas , Rahmawati Ulfa
Published: January 2025

The state treasurer plays an important role in implementing tax obligations related to the use of the APBN/APBD. This study explains the suitability of the implementation of tax obligations by the Treasurer of the University of Papua for PPh capital expenditure in 2023 when compared to applicable provisions. The researcher used a descriptive qualitative method. The results of the study indicate that the implementation of capital expenditure tax obligations is not fully in accordance with the provisions. Based on the results of the study, it is expected that the Manokwari Pratama Tax Office will provide counseling regarding the renewal of tax provisions to treasurers. In addition, the Pratama Tax Office needs to provide counseling for treasurers who do not understand the new tax provisions. Meanwhile, the University of Papua needs to create a forum with the Manokwari Pratama Tax Office in implementing SOPs for financial transactions with other parties.
Analisis Pengaruh Firm Size, Profitabilitas dan Kebijakan Dividen terhadap Market Capitalization dengan Good Corporate Governance sebagai Variabel Moderasi
Authors: Toliang Ermina , Maulana Arief Rio , Saputra Edi
Published: January 2025

This study was conducted to determine the extent of the influence arising from firm size, profitability and dividend policy on market capitalization and whether good corporate governance can moderate the influence to be studied. The companies to be studied are companies listed on the Indonesia Stock Exchange with market capitalization that is always in the top 50 at the end of the year for 3 consecutive years. SPSS version 26 is used in this study as a tool in conducting the analysis. This study uses descriptive statistical tests, Multiple Linear Regression Analysis and moderate regression analysis. The results obtained in this study are that Firm Size and Dividend Policy have an effect on Market Capitalization, while profitability does not have an effect on Market Capitalization.
Islamic Perspective of Educational Communication at Al Qodiri in Forming the Characteristics of Santri
Authors: Nafilah Zulfa Kamilatun , Mujib Ihwan Huda Al
Published: January 2025

One of important aspects of education is related to how this contributes to positive changes on individuals. To do so, communication is always an important part of education especially in shaping students’ characters. This also applies at Islamic boarding schools, widely known as pondok pesantren, in Indonesia. Regarding this matter, kitab kuning which literally translates into the yellow books have been the basis of how to educate santri, students of Islamic boarding schools, to become future individuals with great characters. One of the yellow books learnt at Islamic boarding schools is Ta'lim Mutaallim. This book is one of the obligatory books learnt at Al Qadiri Islamic boarding schools in Jember. This research is a descriptive qualitative research conducted at the Al Qodiri Islamic boarding school in Jember. The results of the study show that there are 7 characters of Islamic perspective of educational communication according to Al Jarnuzi which are conveyed and taught at the Al Qodiri Islamic boarding school in shaping the characteristics of students. Those characters include: 1) the intention to learn, 2) choosing teachers, knowledge, and friends, 3) glorifying knowledge and experts in knowledge, 4) sincerity in seeking knowledge, istiqomah, and noble ideals, 5) trust, 6) wara’, and 7) learning methods
The Messages on the Use of YouTube Channel as a Self-Disclosure Media for Persons with Disabilities on the Anggi Wahyuda Channel
Authors: Nasir Fuad
Published: January 2025

Social media is a means of communication that various people use. Some of them are individuals with disabilities who have been misrepresented in the media and society. The subject of this research is Anggi Wahyuda's YouTube channel, a medium for self-disclosure of its owner. The purpose of this study is to find out messages related to self-disclosure delivered on Anggi Wahyuda's YouTube channel. The method used is a case study. The research then conducted in-depth observations of all aspects of the channel, supported by interviews with the YouTube channel owner and several other relevant informants, including experts from the field of clinical psychology. This study found that the main message to be conveyed was to straighten the general mindset of person with disabilities who were considered miserable.
Pengaruh Pemberian Ekstrak Daun Pandan Wangi (Pandanus Amarillyfolius Roxb) terhadap Berat Testis dan Diamater Tubulus Mencit (Mus Musculus)
Authors: Fajria Lili
Published: January 2025

Pandan Wangi (Pandanus amaryllifolius Roxb) is commonly used by Indonesian people. The chemical contents of pandan wangi are: tannin, saponin, alkaloid, flavonoid, and color essence (DepKes RI, 1997). According to some research on other vegetation such as star fruit (Rezano.A, 2008), which found that the active ingredients have an anti-fertility effect on mice. High-rate population problems in Indonesia nowadays that increased 1.3 percent per year (BPS, 2007) creating a demand for safe, effective, high-reversibility contraception methods which are not influenced by libido and sexual activity. So, herbal medicine is one of the alternatives to provide family planning methods that meet the requirements. The objective of this research was to find out the influence of prescribing pandan wangi leaves extracts in the depreciation of testicle mass weight and diameter of tubulus. The nature of this research was experimental research using a Posttest Only Control Group Design. Research conducted in the laboratory of the Medical Faculty of Andalas University, starting from July 25, 2008, to August 30, 2008. The population was 24 Japanese's strain mice originated from the Mathematics and Sciences Faculty of was used in analyzing with one control group. ANOVA test was used in analyzing with a degree of significance was 95%, and if the results are significant, then it will be extended with a Bonferroni type Multiple Comparisons test (Post Hoc Test). General results of this research initiate that prescribing the extracts of pandan wangi leaves have influences in the depreciation of testicle mass weight p=0.000, tubulus diameter p=0.001. The null hypothesis is rejected (p < 0.05). Meanwhile, at the Bonferroni Multiple Comparisons test found that statistically, there was no significant influence between groups of treatment. As a conclusion of this research, it was that active ingredients containing in pandan wangi leaves could distract the spermatogenesis process on mice in the depreciation of testicle mass weight and diameter of tubulus. Extension research suggested using different and increased prescribing dosages.
Asuhan Keperawatan pada Anak dengan Gangguan Nutrisi Akibat Kanker melalui Pendekatan Model Adaptasi Roy
Authors: Muhsinin  , Deswita
Published: January 2025

Cancer in children has increased over the years, including in Indonesia. This literature review provides an overview of the application of the Roy Adaptation Model nursing care to children with cancer with nutrition problems. The role of nurses needed in the application of the Roy Adaptation Model provides nursing care to children and families in order to behave adaptively during treatment of cancer. Roy Adaptation Model is based on the consideration that children with cancer require special handling and complicated chemotherapy that affects the digestive system disorders that cause malnutrition. The family needs adaptation to care and treat their children continuously. The nursing diagnosis is the main nutritional needs less interference than the body needs. Nursing interventions are given in the form of providing motivation and support to clients and families, health education, monitoring and anthropometric examination, and dental and oral care. Other activities to achieve optimal nursing care include family education regarding the care and treatment of cancer.
Nota editorial
Authors: Bautista-Cabrera Álvaro
Published: January 2025

Nota editorial
Canto de las mujeres de Chalco: asedio erótico, sexualidad femenina y política imperial en un poema en náhuatl del siglo XV
Authors: Ortíz Rodríguez María de las Mercedes
Published: January 2025

En este artículo se analiza en su dimensión erótica y política el poema en náhuatl del siglo XV, “Canto de las mujeres de Chalco”, en el cual se figura la voz de una mujer chalca, entregada como concubina al tlatoani mexica Axayácatl. La concubina expresa una activa sexualidad, reta al tlatoani a un combate erótico y cuestiona su virilidad, asimismo expresa el dolor y la incertidumbre que experimenta en su nueva vida. A la vez, resalta su noble linaje y habla de la política imperial mexica, que ha determinado su vida precaria y su vulnerabilidad.
العقوبات الاقتصادية وتأثيراتها على الاقتصاد الرقمي: دراسة مقارنة (العراق وايران انموذجا)
Authors: د زينة عبد الكريم النجار
Published: January 2025

إن تأثير العقوبات الاقتصادية على الاقتصاد الرقمي في كل من العراق وإيران يُعد أمرًا بالغ الأهمية في الوقت الحالي. فبالرغم من أن كلا البلدين يواجهان تحديات مماثلة، إلا أن طبيعة وآثار تلك العقوبات تختلف بينهما بشكل ملحوظ. تستهدف هذه الدراسة المقارنة بين تأثير العقوبات الاقتصادية على الاقتصاد الرقمي في كل من العراق وإيران، وتحليل هذه الآثار على القطاع الرقمي وعلى مؤشرات الاقتصاد الكلي في البلدين، واعتمد البحث على المنهج الاستنباطي من خلال الأسلوب الوصفي التحليلي. ففي حالة العراق، فإن العقوبات المفروضة على القطاع الرقمي تأتي بشكل رئيسي من قبل الولايات المتحدة الأمريكية, وفي المقابل، فإن إيران تواجه عقوبات أكثر شمولية من قبل مجموعة متنوعة من الجهات الدولية، والتي تمتد لتشمل القطاع المصرفي والتجاري والتكنولوجي على حد سواء، وهذا ما أدى إلى تحديات أكبر في النمو والتطور للاقتصاد الرقمي الإيراني. أظهرت نتائج الدراسة أن العقوبات الاقتصادية المفروضة على العراق وإيران قد أثرت بشكل كبير على قطاع الاقتصاد الرقمي في البلدين, حيث شهد قطاع الاقتصاد الرقمي انخفاضًا في معدلات النمو والاستثمار، مع تراجع مؤشرات التجارة الإلكترونية والخدمات المالية الرقمية, كما أدت العقوبات إلى ارتفاع معدلات البطالة في هذا القطاع. وعلى الرغم من هذه التحديات، فإن كلا البلدين قد بذلا جهودًا كبيرة في محاولة التكيف مع تلك العقوبات والحفاظ على استدامة الاقتصاد الرقمي، إلا أن نجاح تلك الجهود يظل محل نظر في ظل استمرار تأثير العقوبات على هذا القطاع الحيوي.
Features of the Formation of Negatonyms (Based on M. Shruba's "Dictionary of Pseudonyms of Russian Emigrants in Europe (1917–1945)")
Authors: Savel'ev Viktor Sergeevich , Ding Pei
Published: January 2025

The object of this study is negatonyms (negative pseudonyms) of authors from the first wave of Russian emigration in the 20th century. Negatonyms represent a type of pseudonym whose meaning essentially amounts to the negation of what is named by their base. The material for the study consists of negatonyms included in M. Shruba's "Dictionary of Pseudonyms of Russian Emigrants in Europe (1917–1945)." This source includes approximately 9,800 pseudonyms, from which 71 negatonyms were identified. The subject of the research is the peculiarities of the formation of negative pseudonyms, which include the methods and means of their formation (including the producing bases and derivators), types of motivation (determined by the typical lexical meanings of the producing bases of negatonyms), as well as word-formation models (productive and unproductive) used in the formation of negative pseudonyms. The analysis employs a descriptive research method (units of description are distinguished, their properties and characteristics are defined, facts are generalized, and their interpretation is provided). The study identifies the methods and means of formation, spelling peculiarities, and types of motivation for both one-word and multi-word negatonyms. A comparative analysis allows for determining the most productive models. Two peculiarities of negatonyms used by authors of the first wave of emigration between 1917 and 1940 are noted: 1) the meanings of many negative pseudonyms are linked to the realization of the concept of "own" vs. "their" with most pseudonyms reflecting the author's sense of foreignness to the "new world," positioning themselves as someone who does not consider themselves part of it; 2) the political views of the author are regularly indicated—either affiliation with a particular party or, conversely, apoliticality. The study also finds that negatonyms allow authors to demonstrate their creativity in coinage, utilizing various language-play mechanisms.
Rhetorical means of communicative success using question-answer procedures as an example.
Authors: Katunin Aleksandr Viktorovich
Published: January 2025

The article is devoted to the study of the role of question-answer procedures in modern communication conditions. The subject of the study is question-answer procedures. The article explains one of the main distinctions for the topic of the study - the concepts of "ignorance" and “lack of knowledge”. Particular attention is focused on identifying and clarifying the role of the question in modern communication: the characteristics / attributes of the question in modern communication are identified; logical and rhetorical aspects of questions are analyzed; the key concept of "interrogative" for the formal description of questions in logic is clarified; the specificity of the logical basis of the question is shown; the difference between logical and grammatical subjects and predicates is shown; cognitive and manipulative functions of questions are formulated. The article clarifies the meaning of the concept of "communicative goal", and also proposes a variant of dividing questions into correct and incorrect depending on the communicative goal. The article proposes a classification of incorrect questions and a method for answering questions of different types in both personal and professional communicative interaction; general recommendations for response procedures are provided, and types of correct and incorrect answers are demonstrated and analyzed. The article uses methods of comparative and contextual analysis, generalization, classification, and the logical method. The text is accompanied by visual, expressive examples, which allows the reader to better understand the main ideas of the study. The article will be useful for both students, postgraduates studying rhetoric, argumentation theory, communication techniques, and a wide range of readers.
A review of 3D design knowledge and its impact on creativity in fashion design education
Authors: Papahristou Evridiki , Zolota Tatsi Nefeli
Published: January 2025

The rapid technological advancements of Industry 4.0 are reshaping the fashion industry, emphasizing the need for innovative tools and digitally skilled professionals. This study explores the integration of 3D virtual prototyping into fashion design education and its impact on fostering creativity, enhancing technical skills, and preparing students for contemporary industry demands. Drawing upon a detailed literature review and an in-depth case study from the Department of Creative Design & Clothing at the International Hellenic University, this research examines the pedagogical and creative outcomes of incorporating 3D design tools. The implementation of a structured course in 3D virtual prototyping provided students with theoretical knowledge and hands-on experience using advanced software. Findings indicate that 3D design knowledge enhances spatial visualization, critical thinking, and problem-solving skills, while fostering sustainability awareness. The open-themed project assignments encouraged individual and collaborative exploration, empowering students to push creative boundaries while honing technical expertise in virtual garment design, fabric simulation, and rendering techniques. However, some challenges were observed, including the steep learning curve associated with mastering 3D design tools and difficulties managing time during iterative design processes. Despite these hurdles, the experience fostered a deeper sense of confidence and adaptability among students, equipping them to navigate the demands of the evolving apparel industry. This research contributes to the evolving discourse on digital skill development in fashion education, emphasizing the critical role of experiential learning in preparing students for the demands of the modern apparel industry.
Real-World Efficacy of Faricimab in Treatment Resistant Neovascular Age-Related Macular Degeneration: A 12 Month Cohort Study
Authors: W Evans ,   Department of Ophthalmology, Salisbury District Hospital, UK, C Mathew ,   Department of Ophthalmology, Salisbury District Hospital, UK, M Eissa ,   Department of Ophthalmology, Salisbury District Hospital, UK, M Evans ,   Chester Medical School, University of Chester, UK, R Arora ,   Department of Ophthalmology, Salisbury District Hospital, UK
Published: January 2025

Background: Faricimab, the first bispecific anti-VEGF agent, has shown efficacy in treating neovascular Age-Related Macular Degeneration (AMD). However, existing studies often exclude anti-VEGF resistant patients, involve small sample sizes, or focus on short-term outcomes. This study aims to evaluate the real-world outcomes of faricimab in treatment-resistant neovascular AMD patients over a 12-month period.

Methods: This is a single-centre, retrospective cohort study conducted using clinical and imaging data from Salisbury district hospital, UK, between October 2022 to November 2023.

Results: A total of 191 eyes from 156 patients, with a mean age of 81.4 years and a history of 19.9 previous anti-VEGF injections per eye, were analysed. The baseline mean Best-Corrected Visual Acuity (BCVA) was 0.40 ± 0.26, and the mean Central Subfield Thickness (CST) was 283.5 μm ± 67.3 μm. After a mean follow-up of 8 months, patients received a mean of 6.49 ± 1.99 faricimab injections. A significant reduction in CST was observed, with a decrease of 283.5 ± 67.3 μm at baseline to 268.86 ± 75.06 μm at the 12-month interval, indicating anatomical improvement. Notably, the majority of patients were successfully extended to an 8-week injection interval, with a mean interval of 7.8 weeks.

Conclusions: Switching to faricimab in treatment-resistant neovascular AMD patients resulted in anatomical improvement in CST and maintenance of BCVA. These findings suggest that faricimab is a safe and effective treatment, with the potential for prolonged injection intervals. Longer-term follow-up is needed to assess the durability of these results.

Keywords: Faricimab; Neovascular age-related macular degeneration; anti-VEGF
Quercetin Phospholipids Supplementation as a Natural Relief in Osteomuscular Health
Authors:   Azienda Unità Sanitaria Locale (USL) Toscana Centro, 50122 Florence, Italy, Miniati Irene , Davolio Pier Luigi ,   Farmad Laboratori Firenze Srl, Florence, Italy, Busi Simona ,   Farmad Laboratori Firenze Srl, Florence, Italy, Petrangolini Giovanna ,   Medical Department, Indena SpA, 20139 Milan, Italy, Galluccio Felice ,   Fisiotech Lab Studio, Rheumatology and Pain Management, 50136 Florence, Italy
Published: January 2025

Quercetin, a polyphenol substance, was found in several foods, including apples, grapes, onions, berries, broccoli, citrus fruits, green tea, coffee and red wine. The properties of quercetin are well known, including antioxidant/antiinflammatory, vasodilator, anti-allergic, anti-fatigue and senolytic. In the present case reports in joint health, one month quercetin phospholipid supplementation significantly reduced both NRS and FIHOA scores in erosive hand osteoarthritis subjects. No side effects related to the supplementation was detected, thus quercetin phospholipid supplementation would represent a valid safe support in joint health and pain management as add-on natural support.
Upconverting Green Light to Blue via Solid-State Triplet-Triplet Annihilation in Hydrogen-Bonded Organic Frameworks
Authors: Li Alice , Goswami Subhadip , Gostzola David , Schaller Richard , Hupp Joseph
Published: January 2025

The conversion of low energy photons into higher energy photons via triplet-triplet annihilation upconversion (TTA-UC) has important implications for wavelength-shifting technology and is a target for increasing the efficiency of solar energy harvesting. Given that the efficiencies of solid-state TTA-UC are drastically lower than that of solution-phase TTA-UC, strategies are needed to augment the process. Herein, hydrogen-bonded organic frameworks (HOFs) comprised of zinc tetrakis(4-carboxyphenyl)porphyrin (Zn-TCPP) acting as the sensitizer and dipyridyl thiazolothiazole (TzBIPY) acting as the annihilator were synthesized and evaluated for TTA-UC. Modifying the coordination angle of the TzBIPY to the porphyrin, two structures were obtained and characterized via single crystal x-ray diffraction. Using both femtosecond laser excitation of the HOFs as colloidal dispersions in solvent and continuous wave laser excitation on single crystal samples, evidence of superlinear power-dependent emission at 460 nm from TzBIPY upon resonant excitation of Zn-TCPP suggests the occurrence of TTA-UC. This investigation illustrates the potential of HOFs for light harvesting applications and could lead to further development in photocatalysis where the HOF is used as the photosensitizer for encapsulated guests.
Preparation of Sequence-controlled Aliphatic Polysulfones by Group Transfer Radical Polymerization
Authors: Gao Kexiong , Wang Xianjin , Wang Tongkun , Song Silin , Zhu Chen
Published: January 2025

The integration of sulfur atoms into polymer backbones to synthesize S-containing polymers, such as aliphatic polysulfones, renders many unique properties of the materials. Conventional methods are facing great challenges to achieve sequence-controlled aliphatic polysulfones with high molecular weight (MW), significantly restricting the use of these polymers. We devise a novel approach for the preparation of aliphatic polysulfones via sulfonyl radical-mediated group transfer radical polymerization (GTRP). The polymerization proceeds through a practical SO2-free pathway, producing a series of ABC sequence-defined high-MW polymers (up to 199 kg/mol). DFT calculations are conducted, which support the radical Smiles rearrangement pathway involved in the GTRP process.
Performance of survey solutions under single-blind controlled testing protocol.
Authors: Ilonze Chiemezie , Day Rachel , Emerson Ethan , Duggan Aidan , Brouwer Ryan , Zimmerle Dan
Published: January 2025

Standardized controlled testing of advanced methane detection technologies (solutions) has been identified as a step in demonstrating the emissions mitigation equivalence between these solutions and existing regulatory-approved leak detection and repair methods (e.g., ground-based optical gas imaging [OGI] camera survey) in the US and Canada. In this study, 12 solutions consisting of 4 handheld OGI cameras, 4 advanced handheld systems, and 4 mobile (automobile- and drone-based) solutions were tested under a single-blind controlled testing protocol at different periods between 2021 and 2023 at an outdoor test facility that simulates emissions from a simple, onshore North American production oil and gas (O&G) facility. Three solutions were tested again 3–12 months after the first test, using the same test protocol and facility to assess how performance changed over time. Results showed that handheld OGI cameras had comparable or better performance in terms of lower 90% probability of detection (DL90), false positive and negative fractions, and higher equipment unit-level localization performance compared to other categories of solutions tested. Advanced handheld solutions had comparable performance with the OGI cameras across all metrics except false positive fraction (much higher), while mobile solutions generally had shorter survey durations compared to other solutions. For solutions that tested twice, the performance of 2 of 3 solutions generally improved, illustrating the benefit of regular, comprehensive testing in the development of solutions. The different value propositions inferred from the various categories of solutions tested suggest that mobile solutions can rapidly survey larger areas to inform more targeted, follow-up inspections with handheld solutions. While advanced handheld solutions can be as effective as OGI cameras, mobile solutions have some difficulties to overcome to make them directly comparable or need to have a different use case.
Investigating The Biochemical Methane Potential of Kumasi's Municipal Solid Wastes
Authors: Darmey J. , Narra S. , Achaw O-W. , Amoatey N. K. , Tabbicca K. E. , Ahiekpor J. C.
Published: January 2025

Purpose: This paper aims to ascertain the biochemical methane potential of organic waste generated in Kumasi for renewable energy production.
Design/Methodology/Approach: A quantitative experimental approach was employed on Batch anaerobic digestion experiments, and methane yields were analysed with kinetic models.
Findings: The modified Gompertz model had the best fit, with a R² = 0.9962, which gave a methane production rate of 19.47 ml CH₄ g⁻¹ VS Day and a BMP of 219.35 ml CH₄ g⁻¹ VS.
Research Limitation: It has also been pointed out that further optimisation of AD processes for methane yield and efficiency is required. Key limitations pertain to scalability and unoptimised parameters.
Practical Implication: The study confirms that organic waste-to-biogas conversion in Kumasi is viable and represents a partial solution to problems of organic waste management and renewable energy generation.  That will reduce disposal costs from waste, low dependence on fossil fuel, and open opportunities in resource recovery for operational efficiencies that work toward environmental sustainability.
Social Implication: Better waste management will help reduce environmental pollution. In addition, appropriate development in terms of sustainability and enhancement of energy security will occur.
Originality/Value: This research provides information on wastes around Kumasi that can be used to produce biogas and advance sustainable waste-to-energy practices. This study introduces a novel application of kinetic models to assess Kumasi’s organic waste for biogas production, offering localised data and tailored optimisation strategies. It contributes to advancing waste-to-energy practices and supports sustainable waste management in Ghana.
Smart Sustainable Cities Implementation in Zambia: The Influence of Local Culture
Authors: Chipulu C. , Kaliba C. , Mwiya B.
Published: January 2025

Purpose: This study examines the relationship between culture and the barriers to implementing smart sustainable cities (SSCs) in Zambia.
Methods: This article utilised a quantitative research approach, conducting a questionnaire survey of ninety-two (92) purposively selected respondents from architecture, engineering, construction, security, healthcare, and governance sectors in both public and private organisations. The study employed correlation analysis using the Kendall tau-b to examine the relationship between culture and the challenges of implementing SSC.
Findings: The findings showed a positive correlation of varying significance between culture and the barriers to SSC implementation in Zambia. A significant correlation was observed between culture and insufficient use of ICT for environmental sustainability and energy efficiency as well as centralised decision-making. Other barriers strongly associated with culture included a lack of ICT knowledge and information sharing, standardised assessment frameworks for SSC, and proper implementation of local area plans.
Research Limitation: The disproportionate regional representation in the sample may limit the generalizability of the findings across Zambia.
Practical implications: Recognizing the link between barriers to SSC implementation in Zambia and local culture highlights the importance of investing in understanding local culture before any SSC development, as this could be crucial for project success in culturally diverse contexts.
Social Implication: Considering local culture in SSC development can enhance the inclusion of citizens from diverse cultural backgrounds.
Originality/ Value: The research highlights the correlation between cultural factors and the challenges in establishing SSCs, emphasising the need to integrate cultural considerations to enhance inclusivity in their development.
Analysis of moral decadent behaviour and student manners in Pesantren
Authors: Deriansyah Ryan , Baharuddin Mochammad Achwan , Nasaruddin Razie Bin
Published: January 2025

Islamic boarding schools are known as educational institutions that teach morals and manners. However, currently the morals and manners of students are experiencing decadence or decline. This is allegedly due to changes in the internal and external community of the Pesantren. The purpose of this study is to analyse the behaviour of deterioration of morals and manners in students in Islamic boarding schools. The research used a qualitative approach by taking data through interviews, observations, and documentation. The validity of the data was analysed by triangulation techniques, then data analysis was carried out by data reduction, data appearance, and conclusions. The results of the study show that the decadence of morals and manners that occur in Pesantren is shown by the behaviour of manners, the attitude of ta'dzim santri to teachers, guests, and parents that decreases. In addition, there are cases of bullying,  violence against fellow students, and acts of theft of goods. There are internal and external factors that are the cause of moral decadent behaviour, internal factors that are related to the personality background of students who are formed in the family and environment before becoming santri in boarding school. External factors, namely the families of students and the environment of students in the boarding schools.
Occlusive splints for the treatment of patients with musculotendinous dysfunction. Basics of construction
Authors: Boian A.M. , Nikonov A.Yu. , Breslavets N.M. , Herman S.I.
Published: January 2025

Relevance. Complex treatment of patients with musculotendinous dysfunction of the temporomandibular joint (TMJ MTD) in most clinical cases includes the use of therapeutic occlusal splints. The multifactorial etiology of this disease causes multisymptomatic clinical manifestations, so treatment with occlusal splints aims at primary relief or elimination of myofascial pain, as the most prominent symptom, by improving the functional position of the muscles and stabilizing balanced occlusion and central ratio. However, the percentage of prolonged treatment efficacy, according to the literature, ranges from 30% to 95%. Therefore, studying the effectiveness of treatment of patients with musculotendinous dysfunction of the temporomandibular joint with the use of occlusal splints is an urgent issue.

The aim of the work is to study the design features, principle of action and recommendations for the use of occlusal splints, which are offered for the treatment of musculotendinous dysfunction of the temporomandibular joint.

Materials and Methods. A systematized literature review was conducted, the main types of occlusal splints for the treatment of musculotendinous dysfunction of the temporomandibular joint with recommendations for their use were considered. The design features, materials used and technologies of splints manufacturing were analyzed.

Results and discussion. The analysis of literature sources suggests a pronounced therapeutic effect of occlusal splints, especially in the treatment of patients with functionally determined diseases of the dento-mandibular system, such as myoarthropathies, which include TMJ MTD, as well as bruxism. However, the question of choosing the exact type of occlusal splints, determining the duration of treatment, the frequency of correction, the sequence of application of different types of splints if necessary, etc. remains debatable. All these positions are correlated and interrelated with the degree of severity of the disease and severity of symptoms, so it is important to maximize the time to eliminate the symptoms of TMJ MTD, restore the physiological state of masticatory muscles and central jaw relationship.

Conclusions. Treatment of patients with TMJ MTD with the help of occlusal splints should be aimed at maximum complete elimination of the disease symptoms with minimum treatment time.
Kebijakan Hukum Pidana Sebagai Upaya Penanggulangan Tindak Pidana Penipuan Online
Authors: Maaliki Naavi’u Emal
Published: January 2025

The aim of this research is to identify the rules regarding criminal acts of online fraud as seen in Article 28 of the ITE Law, Article 53 of the ITE Law, Article 378 of the Criminal Code, Article 372 of the Criminal Code, because the a quo articles require strong evidence and a deep understanding of information technology. and communication. The urgency of this research is that many law enforcers are unable to identify articles related to technology and communications. The research method uses the Normative legal method, because this research is only aimed at written regulations so this research is very close to the provisions in the library because it will require secondary data in the library. The results of this research are that law enforcement agencies need to have the ability to carry out digital investigations, forensic analysis, and cross-border cooperation to handle complex and cross-border online fraud cases. Reform of national law as part of a series of national development is carried out in a comprehensive and integrated manner, including criminal law, civil law and administrative law, and also includes formal law and material law.

Tujuan dari penelitian ini untuk mengidentifikasi aturan mengenai tindak pidana penipuan online yang dilihat dalam Pasal 28 UU ITE, Pasal 53 UU ITE, Pasal 378 KUHP, Pasal 372 KUHP, sebab pasal-pasal a quo memerlukan bukti yang kuat dan pemahaman yang mendalam tentang teknologi informasi dan komunikasi. Urgensi penelitian ini adalah banyaknya penegak hukum tidak mampu mengindetifikasikan pasal-pasal yang berakitan dengan teknologi dan komunikasi. Metode penelitian menggunakan metode hukum normatif, karena penelitian ini hanya ditujukan pada peraturan-peraturan tertulis sehingga penelitian ini sangat erat hubungannya pada pada perpustakaan karena akan membutuhkan data-data yang bersifat sekunder pada perpustakaan. Adapun hasil penelitian ini adalah lembaga penegak hukum perlu memiliki kemampua untuk melakukan investigasi digital, analisis forensik, dan kerja sama lintas negara untuk menangani kasus-kasus penipuan online yang kompleks dan lintas batas. Pembaharuan hukum nasional sebagai bagian dari rangkaian pembangunan nasional ini dilakukan secara menyeluruh dan terpadu baik hukum pidana, hukum perdata maupun hukum administrasi, dan meliputi juga hukum formil maupun hukum materiilnya.
Urgensi Kepatuhan Hukum dalam Pemenuhan Klaim Asuransi di Indonesia: Perspektif Kontraktual dan Implikasinya
Authors: Siregar Raquel Nabila Azka , Satino Satino
Published: January 2025

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The Urgency Regulation Prohibition of Social Commerce in Indonesia From The Perspective Maslahah Mursalah
Authors: Oktavia Dian Novyta , Batubara Chuzaimah
Published: January 2025

This research aims to determine the importance of social commerce regulations, explore the development and implementation of these regulations in Indonesia, and understand Maslahah Mursalah's views on these regulations. The current rapid growth of digital technology has driven great progress in various scientific disciplines, particularly in the economic sector, where business actors, especially MSMEs, are starting to participate in the e-commerce space. With the emergence of online trading trends that use social media as the main platform (social commerce), government awareness of the growth potential of e-commerce has encouraged the government to adopt strict and enforceable regulations. This scientific study uses normative juridical research methodology, specifically focussing on secondary data sources. These sources include primary legal materials, such as statutory regulations (legislative approach), and secondary legal sources accessed through library sources. The study revealed that the Minister of Trade, Zulkifli Hasan, has issued new regulations, namely Minister of Home Affairs Regulation (Permendagri) Number 31 of 2023 concerning Licensing, Advertising, Development, and Supervision of Trading Business Entities via Electronic Systems. This law aims to help Micro, Small, and Medium Enterprises (MSMEs), clarify social commerce operations, and foster a strong e-commerce ecosystem. However, some view the government's issuance of this regulation as lacking substance and haste. Mursalah's problem is that government regulations, specifically Minister of Trade Regulation Number 31 of 2023, only address a few aspects of enhancing human welfare, particularly for commercial actors.