bluuebunny/crossref_metadata_2025 huggingface dataset:
Crystallographic interacting topological phases and equivariant cohomology: to assume or not to assume
Authors: Sheinbaum Daniel , Camarena Omar Antolín
Published: July 2021

Abstract

For symmorphic crystalline interacting gapped systems we derive a classification under adiabatic evolution. This classification is complete for non-degenerate ground states. For the degenerate case we discuss some invariants given by equivariant characteristic classes. We do not assume an emergent relativistic field theory nor that phases form a topological spectrum. We also do not restrict to systems with short-range entanglement, stability against stacking with trivial systems nor assume the existence of quasi-particles as is done in SPT and SET classifications respectively. Using a slightly generalized Bloch decomposition and Grassmanians made out of ground state spaces, we show that the P-equivariant cohomology of a d-dimensional torus gives rise to different interacting phases, where P denotes the point group of the crystalline structure. We compare our results to bosonic symmorphic crystallographic SPT phases and to non-interacting fermionic crystallographic phases in class A. Finally we discuss the relation of our assumptions to those made for crystallographic SPT and SET phases.
Magnetic resonance imaging incidents are severely underreported: a finding in a multicentre interview survey
Authors: Kihlberg Johan , Hansson Boel , Hall Annika , Tisell Anders , Lundberg Peter
Published: July 2021

Objectives

The purpose of this study was to develop a procedure to investigate the occurrence, character and causes of magnetic resonance (MR) imaging incidents.

Methods

A semi-structured questionnaire was developed containing details such as safety zones, examination complexity, staff MR knowledge, staff categories, and implementation of EU directive 2013/35. We focused on formally reported incidents that had occurred during 2014–2019, and unreported incidents during one year. Thirteen clinical MR units were visited, and the managing radiographer was interviewed. Open questions were analysed using conventionally adopted content analysis.

Results

Thirty-seven written reports for 5 years and an additional 12 oral reports for 1 year were analysed. Only 38% of the incidents were reported formally. Some of these incidents were catastrophic. Negative correlations were observed between the number of annual incidents (per scanner) and staff MR knowledge (Spearman’s rho − 0.41, p < 0.05) as well as the number of MR physicists per scanner (− 0.48, p < 0.05). It was notable that only half of the sites had implemented the EU directive. Quotes like ‘Burns are to be expected in MR’ and not even knowing the name of the incident reporting system suggested an inadequate safety culture. Finally, there was a desire among staff for MR safety education.

Conclusions

MR-related incidents were greatly underreported, and some incidents could have had catastrophic outcomes. There is a great desire among radiographers to enhance the safety culture, but to achieve this, much more accessible education is required, as well as focused involvement of the management of the operations.

Key Points

• Only one in three magnetic resonance–related incidents were reported.

• Several magnetic resonance incidents could have led to catastrophic consequences.

• Much increased knowledge about magnetic resonance safety is needed by radiologists and radiographers.
In vivo corneal confocal microscopy and optical coherence tomography on eyes of participants with type 2 diabetes mellitus and obese participants without diabetes
Authors: Tóth Noémi , Silver David M. , Balla Szabolcs , Káplár Miklós , Csutak Adrienne
Published: July 2021

Purposes

To examine corneal nerve and retinal nerve characteristics of participants with type 2 diabetes mellitus (T2DM) compared with obese participants without diabetes to discover potential nerve vulnerabilities.

Methods

All participants underwent a complete medical examination including a physical examination and blood sample tests. The ophthalmologic examination included best-corrected visual acuity, intraocular pressure, Schirmer test, tear film breakup time, slit-lamp examination, dilated fundus photography, in vivo corneal confocal microscopy (IVCCM), and optical coherence tomography (OCT).

Results

The study cohort consisted of 83 eyes of 83 individuals: a group of 44 participants with T2DM, and a control group of 39 obese participants with no history of diabetes. Comparing measurements on the two groups, participants with T2DM had lower values with statistical significance for retinal nerve fiber layer (RNFL) nasal superior thickness (p = 0.010) and three corneal nerve (CN) parameters: fiber length (p = 0.025), total branch density (p = 0.013), and fiber area (p = 0.009). There was a borderline significant difference in CN fiber width (p = 0.051) and RNFL nasal inferior thickness (p = 0.056). No other significant differences were observed in the IVCCM and OCT parameters. No statistically significant correlation was found between CN and RNFL parameters.

Conclusions

Progression from a pre-diabetic obese state to a T2DM condition might entail a loss or diminishment of certain corneal nerve fibers or retinal nerve fibers, but not necessarily a loss of both corneal and retinal nerve fibers simultaneously. Using IVCCM and OCT together enables monitoring of both corneal and retinal health of the eye.
The role of the calibrated automated thrombogram in neonates: describing mechanisms of neonatal haemostasis and evaluating haemostatic drugs
Authors: Murphy Claire A. , Neary Elaine , O’Reilly Daniel P. , Cullivan Sarah , EL-Khuffash Afif , NíAinle Fionnuala , Maguire Patricia B. , McCallion Naomi , Kevane Barry
Published: July 2021

Premature infants are at high risk of haemorrhage and thrombosis. Our understanding of the differences between the neonatal and adult haemostatic system is evolving. There are several limitations to the standard coagulation tests used in clinical practice, and there is currently a lack of evidence to support many of the transfusion practices in neonatal medicine. The evaluation of haemostasis is particularly challenging in neonates due to their limited blood volume. The calibrated automated thrombogram (CAT) is a global coagulation assay, first described in 2002, which evaluates both pro- and anti-coagulant pathways in platelet-rich or platelet-poor plasma. In this review, the current applications and limitations of CAT in the neonatal population are discussed.

Conclusion: CAT has successfully elucidated several differences between haemostatic mechanisms in premature and term neonates compared with adults. Moreover, it has been used to evaluate the effect of a number of haemostatic drugs in a pre-clinical model. However, the lack of evidence of CAT as an accurate predictor of neonatal bleeding, blood volume required and the absence of an evidence-based treatment algorithm for abnormal CAT results limit its current application as a bedside clinical tool for the evaluation of sick neonates.

What is Known:• The Calibrated automated thrombogram (CAT) is a global coagulation assay which evaluates pro- and anti-coagulant pathways.• CAT provides greater information than standard clotting tests and has been used in adults to evaluate bleeding risk.

What is New:• This review summarises the physiological differences in haemostasis between neonates and adults described using CAT.• The haemostatic effect of several drugs has been evaluated in neonatal plasma using CAT.
Negative relationship between dry matter intake and the temperature-humidity index with increasing heat stress in cattle: a global meta-analysis
Authors: Chang-Fung-Martel J. , Harrison M. T. , Brown J. N. , Rawnsley R. , Smith A. P. , Meinke H.
Published: July 2021

Changes in frequency and severity of heat waves due to climate change pose a considerable challenge to livestock production systems. Although it is well known that heat stress reduces feed intake in cattle, effects of heat stress vary between animal genotypes and climatic conditions and are context specific. To derive a generic global prediction that accounts for the effects of heat stress across genotypes, management and environments, we conducted a systematic literature review and a meta-analysis to assess the relationship between dry matter intake (DMI) and the temperature-humidity index (THI), two reliable variables for the measurement of feed intake and heat stress in cattle, respectively. We analysed this relationship accounting for covariation in countries, breeds, lactation stage and parity, as well as the efficacy of various physical cooling interventions. Our findings show a significant negative correlation (r =  − 0.82) between THI and DMI, with DMI reduced by 0.45 kg/day for every unit increase in THI. Although differences in the DMI-THI relationship between lactating and non-lactating cows were not significant, effects of THI on DMI varied between lactation stages. Physical cooling interventions (e.g. provision of animal shade or shelter) significantly alleviated heat stress and became increasingly important after THI 68, suggesting that this THI value could be viewed as a threshold for which cooling should be provided. Passive cooling (shading) was more effective at alleviating heat stress compared with active cooling interventions (sprinklers). Our results provide a high-level global equation for THI-DMI across studies, allowing next-users to predict effects of heat stress across environments and animal genotypes.
Mechanische Feldschwächung einer Multi-Rotor-Permanentmagnet- Synchronmaschine
Authors: Brunner Andreas , Spießberger Richard , Schrödl Manfred
Published: July 2021

In dieser Arbeit wird ein Konzept einer neuartigen mechanischen Feldschwächmethode am sogenannten elektrischen Planetenmotor präsentiert. Der elektrische Planetenmotor ist eine Kombination aus einer elektrischen Maschine mit mehreren Rotoren in einem gemeinsamen Stator und einem Getriebeteil, wobei die spezielle Anordnung des Getriebes zur mechanischen Feldschwächung genützt werden kann. Es wird die theoretische Grundlage dafür erarbeitet sowie die Funktionsweise anhand von Messungen an einem Prototyp demonstriert.
Frailty as a novel predictor of achieving comprehensive disease control (CDC) in rheumatoid arthritis
Authors: Salaffi Fausto , De Angelis Rossella , Farah Sonia , Carotti Marina , Di Carlo Marco
Published: July 2021

Background

Frailty is a construct recently introduced in the context of inflammatory joint diseases. To date, it is not clear if frailty can act as a negative factor in the achievement of comprehensive disease control (CDC) in patients suffering from rheumatoid arthritis (RA).

Aim

To verify whether frailty is a factor hindering the achievement of CDC in patients with RA starting a biologic drug.

Methods

RA patients requiring a treatment with a biologic drug were included. Patients were classified as achieving or not achieving CDC after 12 months of treatment. Patients were classified as non-frail, mildly frail, moderately frail and severely frail according to the Comprehensive Rheumatologic Assessment of Frailty (CRAF). Frailty was tested using the Mann–Whitney or Kruskal-Wallis test for continuous variables and chi-square test or Fisher’s exact test for comparison with categorical variables. A multivariable logistic regression was performed to identify factors associated with prediction of CDC achievers.

Results

A total of 214 RA patients were followed for 12 months, 14.5% achieved CDC. Eighty-four (39.3%) patients were non-frail, 57 (26.6%) were mildly frail, 14 (6.5%) were moderately frail and 59 (27.6%) were severely frail. The multivariable logistic regression analysis identified the CRAF score at baseline as an independent variable for CDC achievement at 12 months (p = 0.0040).

Discussion

Frailty is a frequent condition in RA patients and reduces the chances of achieving CDC.

Conclusions

Frailty, measured by CRAF, reduced the likelihood of CDC achievement in RA patients treated with a biologic agent.

Key Points• Frailty is an under-researched condition in rheumatoid arthritis affecting more than 60% of patients.• Frailty is a condition that hinders the achievement of comprehensive disease control after 1 year of treatment with biological drugs in patients with rheumatoid arthritis.
The Moral Duty to Love One’s Stakeholders
Authors: Kaptein Muel
Published: July 2021

Much has been written about the general moral duty to love one’s neighbors. In this article, I explore the specific application of this moral duty in the work setting. I argue from a secular perspective that individuals have the moral duty to love their stakeholders. Loving one’s stakeholders is an affective valuing of the stake-related values these stakeholders pursue and as such is the real recognition of one’s stakeholders as stakeholders and of oneself as a stakeholder of one’s stakeholders. This moral concept of stakeholder love offers promising contributions to stakeholder theory, leadership theories, and ethical theories in general and business ethics theories in particular.
Comparison between myocardial function assessed by echocardiography during hospitalization for COVID-19 and at 4 months follow-up
Authors: van den Heuvel F. M. A. , Vos J. L. , van Bakel B. , Duijnhouwer A. L. , van Dijk A. P. J. , Dimitriu-Leen A. C. , Koopmans P. C. , de Mast Q. , van de Veerdonk F. L. , Bosch F. H. , van den Borst B. , Eijsvogels T. M. H. , van Kimmenade R. R. J. , Nijveldt R.
Published: July 2021

In patients hospitalized for corona virus infectious disease 19 (COVID-19) it is currently unknown whether myocardial function changes after recovery and whether this is related to elevated cardiac biomarkers. In this single center, prospective cohort study we consecutively enrolled hospitalized COVID-19 patients between 1 April and 12 May 2020. All patients underwent transthoracic echocardiography (TTE) evaluation during hospitalization and at a median of 131 days (IQR; 116–136) follow-up. Of the 51 patients included at baseline, 40 (age: 62 years (IQR; 54–68), 78% male) were available for follow-up TTE. At baseline, 68% of the patients had a normal TTE, regarding left ventricular (LV) and right ventricular (RV) volumes and function, compared to 83% at follow-up (p = 0.07). Median LV ejection fraction (60% vs. 58%, p = 0.54) and tricuspid annular plane systolic excursion (23 vs 22 mm, p = 0.18) were comparable between hospitalization and follow-up, but a significantly lower RV diameter (39 vs. 34 mm, p = 0.002) and trend towards better global longitudinal strain (GLS) (− 18.5% vs − 19.1%, p = 0.07) was found at follow-up. Subgroup analysis showed no relation between patients with and without elevated TroponinT and/or NT-proBNP during hospitalization and myocardial function at follow-up. Although there were no significant differences in individual myocardial function parameters at 4 months follow-up compared to hospitalisation for COVID-19, there was an overall trend towards normalization in myocardial function, predominantly due to a higher rate of normal GLS at follow-up.
A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS
Authors: Kotsias Maximilianos , Madunić Katarina , Nicolardi Simone , Kozak Radoslaw P. , Gardner Richard A. , Jansen Bas C. , Spencer Daniel I. R. , Wuhrer Manfred
Published: July 2021

The study of protein O-glycosylation is important in biological research as O-glycans have been reported to regulate a multitude of molecular and cell biology processes occurring in cancer. It is known that alterations in O-glycosylation are involved in the development and progression of cancer. Their easy accessibility makes in vitro established cell lines suitable and useful models for studying biological mechanisms in disease. However, the O-glycosylation analysis of large numbers of samples, as required in systems biology and biomarker discovery studies, is often challenging. In the present study, O-glycans from three human colorectal cancer cell lines and two human pancreatic cancer cell lines were released by semi-automated, high throughput reductive β-elimination and analysed using ultrahigh resolution MALDI-FT-ICR MS. Automated data integration and processing was performed using MassyTools, where the analyte was automatically included for relative quantitation based on a range of selection criteria including signal-to-noise ratio, mass error and isotopic pattern quality scores. A total of 126 O-glycan compositions, ranging from a single monosaccharide to large oligosaccharides exhibiting complex glycan motifs, were detected. The use of ultrahigh resolution MALDI-FTICR MS enabled glycan identification and quantitation in the matrix region of the spectrum. This approach has the potential to be used for O-glycosylation analysis of large numbers of samples, such as patient sample cohorts.
Health Information Source Characteristics Matter: Adapting the Dissemination of an HPV Vaccine Intervention to Reach Latina and Vietnamese Women
Authors: Hopfer Suellen , Duong Huong T. , Garcia Samantha , Tanjasiri Sora P.
Published: July 2021

Latina and Vietnamese women are disproportionately burdened by human papillomavirus (HPV)-associated cervical cancer and underutilize the HPV vaccine, which is an effective cancer prevention measure. To inform the adaptation of a National Cancer Institute’s evidence-based cancer control program, HPV Vaccine Decision Narratives, and because of the rapidly changing information concerning consumption patterns of young adults, we elicited preferences and characteristics associated with women’s interest in various health information sources, specifically for HPV vaccination. We conducted 50 interviews with young Latina and Vietnamese women at two Planned Parenthood health centers in Southern California. Interview questions were guided by the Channel Complementarity Theory and focused on understanding the multiple communication channels women turn to for health, and the characteristics that motivate their use. Our results showed that Latina and Vietnamese women turn to many sources, from online and social media to school health classes, mothers, and doctors. Specific characteristics that motivate women’s online use of health information included immediacy and access, convenience and credibility. When receiving HPV vaccine information, privacy, avoiding information overload, interpersonal engagement, and receiving health information from trusted sources was important. Our study advances the prevention literature by elevating the role of platform delivery considerations and emphasizing preferences to effectively reach Latina and Vietnamese women, who are disproportionately burdened by HPV cancers and are less aware of HPV vaccine prevention. These results can be used to further inform the dissemination of this cancer control program. Adaptation of the program should include changes to its delivery, such that trusted sources are used, and dissemination is coordinated to send a consistent message across multiple communication methods.
Solar Cycle Dependence of ICME Composition
Authors: Song Hongqiang , Li Leping , Sun Yanyan , Lv Qi , Zheng Ruisheng , Chen Yao
Published: July 2021

Coronal mass ejections (CMEs) belong to the most energetic explosions in the solar atmosphere, and their occurrence rates exhibit obvious solar cycle dependence with more events taking place around solar maximum. Composition of interplanetary CMEs (ICMEs), referring to the charge states and elemental abundances of ions, opens an important avenue to investigate CMEs. In this paper, we conduct a statistical study on the charge states of five elements (Mg, Fe, Si, C, and O) and the relative abundances of six elements (Mg/O, Fe/O, Si/O, C/O, Ne/O, and He/O) within ICMEs from 1998 to 2011, and find that all the ICME compositions possess a solar cycle dependence. All of the ionic charge states and most of the relative elemental abundances are positively correlated with sunspot numbers (SSNs), and only the C/O ratios are inversely correlated with the SSNs. The compositions (except the C/O) increase with the SSNs during the ascending phase (1998–2000 and 2009–2011) and remain elevated during solar maximum and descending phase (2000–2005) compared to solar minimum (2007–2009). The charge states of low-FIP (first ionization potential) elements (Mg, Fe, and Si) and their relative abundances are correlated well, while no clear correlation is observed between the C6+/C5+ or C6+/C4+ and C/O. Most interestingly, we find that the Ne/O ratios of ICMEs and slow solar wind have the opposite solar cycle dependence.
Performance and programmability comparison of the thick control flow architecture and current multicore processors
Authors: Forsell Martti , Nikula Sara , Roivainen Jussi , Leppänen Ville , Träff Jesper Larsson
Published: July 2021

Commercial multicore central processing units (CPU) integrate a number of processor cores on a single chip to support parallel execution of computational tasks. Multicore CPUs can possibly improve performance over single cores for independent parallel tasks nearly linearly as long as sufficient bandwidth is available. Ideal speedup is, however, difficult to achieve when dense intercommunication between the cores or complex memory access patterns is required. This is caused by expensive synchronization and thread switching, and insufficient latency toleration. These facts guide programmers away from straight-forward parallel processing patterns toward complex and error-prone programming techniques. To address these problems, we have introduced the Thick control flow (TCF) Processor Architecture. TCF is an abstraction of parallel computation that combines self-similar threads into computational entities. In this paper, we compare the performance and programmability of an entry-level TCF processor and two Intel Skylake multicore CPUs on commonly used parallel kernels to find out how well our architecture solves these issues that greatly reduce the productivity of parallel software development. Code examples are given and programming experiences recorded.
Morpho-anatomical and biochemical changes associated with rooting of micropropagated ninebark cuttings
Authors: Jagiełło-Kubiec Katarzyna , Nowakowska Karolina , Łukaszewska Aleksandra Józefina , Pacholczak Andrzej
Published: July 2021

Ninebark (Physocarpus opulifolius) is an attractive ornamental shrub with poor rooting characteristics in some cultivars, which is a limiting factor in commercial production This study was designed to optimize rooting conditions of ninebark cuttings and to observe the effect of exogenous auxin IBA on some morpho-anatomical and biochemical changes associated with rhizogenesis in the in vitro conditions. Both auxins under study: the indole-3-butyric acid (IBA) and 1-naphthalene acetic acid (NAA) gave comparable effects but the combination of ½ MS + 1 mg·L−1 IBA was the most cost effective for all rooting parameters. Anatomical changes at the cuttings’ bases during root formation were typical for woody plants and they were accelerated by auxin in the culture medium. High levels of the endogenous indole acid and hydrogen peroxide were temporarily associated with intensive cell divisions in cuttings, and the polyphenolic acid contents kept increasing during rooting above the initial levels and those in controls.
Advances in the Whipple Shield Design and Development:
Authors: Pai A. , Divakaran R. , Anand S. , Shenoy S. B.
Published: July 2021

Safety of satellites as well as spacecrafts during space missions is a primary objective to preserve the physical and virtual assets onboard. Whipple shields belong to the class of protective equipment provided on the surface of the spacecrafts and satellites, to sustain impacts from the ultra-high speed debris, which can otherwise cause considerable damage to the corresponding structures. Recent works on whipple shields are focussed on determining the response of different geometrical arrangements and material properties under hyper-velocity impact at projectile speeds of 3-18 km/s. Advances in the whipple shield design include integrated and mechanised models employing high performance materials like fiber-metal laminates ensuring better operational capability. The forward bumper of the whipple shield is the first line of defence as it regulates the state of projectile after the primary impact. Use of aluminium alloys for front bumpers is popular, owing to their lightweight and strength characteristics. The advances for the front bumper have seen usage of ceramic, metallic foams, and super composite mixtures, which resulted in enhanced performance, durability and safety of the whipple shields. This work is a comprehensive coverage of the latest materials used for whipple shields, their performance characterization—both experimental and theoretical, and applications.
Adolescents with different life problems seeking help before and after the introduction of a low-threshold service model: a Finnish qualitative study
Authors: Leppäkoski Tuija , Paavilainen Eija
Published: July 2021

There are several concerns related to adolescents living in families with severe and persistent problems. Childhood conditions may contribute to later social exclusion, for example. The aim of this study was to describe study participants’ service experiences before and after the introduction of a low-threshold service model. This model—based on the reformed Youth Act—was developed and implemented during a 2-year project. Data were collected through interviews of seven adolescents during phase one. In phase two, four adolescents responded to essay questions. The views of a youth worker working for this project were also collected, as she played a key role in helping the adolescents. The adolescents participating in this study were girls aged between 12 and 17. Thematic deductive analysis was performed. Two main themes were evident in the participants’ responses regarding their service experiences: the accessibility and acceptability of services. The model highlights the importance of listening to adolescents related to their various problems. The focus is on preventive services and early support. Coordination of preventive services requires special expertise and joint development in inter-professional practices. Moreover, adolescents’ experiences should be taken into consideration in the development of services.
The Implications of Global Change for the Co‐Evolution of Argentina's Integrated Energy‐Water‐Land Systems
Authors: Wild Thomas B. , Khan Zarrar , Zhao Mengqi , Suriano Micaela , Bereslawski Julia L. , Roberts Paula , Casado Jose , Gaviño‐Novillo Marcelo , Clarke Leon , Hejazi Mohamad , Miralles‐Wilhelm Fernando , Muñoz‐Castillo Raul , Vernon Chris , Snyder Abigail , Yarlagadda Brinda , Birnbaum Abigail , Lamontagne Jonathan , White Dave , Ojeda‐Matos Glorynel
Published: July 2021

This study seeks to understand how Argentina's energy, water, and land (EWL) systems will co‐evolve under a representative array of human and earth system influences, including socioeconomic change, climate change, and climate policy. To capture Argentina's sub‐national EWL dynamics in the context of global change, we couple the Global Change Analysis Model with a suite of consistent, gridded sectoral downscaling models to explore multiple stakeholder‐engaged scenarios. Across scenarios, Argentina has the economic opportunity to use its vast land resources to satisfy growing domestic and international demand for crops, such as oil (e.g., soy) and biomass. The human (rather than earth) system produces the most dominant changes in mid‐century EWL resource use. A Reference scenario characterized by modest socioeconomic growth projects a 40% increase in Argentina's agricultural production by 2050 (relative to 2020) by using 50,000 km2 of additional cropland and 40% more water. A Climate Policy scenario designed to achieve net‐zero carbon emissions globally shortly after mid‐century projects that Argentina could use 100,000 km2 of additional land (and 65% more water) to grow biomass and other crops. The burden of navigating these national opportunities and challenges could fall disproportionately on a subset of Argentina's river basins. The Colorado and Negro basins could experience moderate‐to‐severe water scarcity as they simultaneously navigate substantial irrigated crop demand growth and climate‐induced declines in natural water availability. Argentina serves as a generalizable testbed to demonstrate that multi‐scale EWL planning challenges can be identified and managed more effectively via integrated analysis of coupled human‐earth systems.
Is Westward Travelling Surge Driven by the Polar Cap Flow Channels?
Authors: Ma Yu‐Zhang , Zhang Qing‐He , Lyons Larry R. , Liu Jiang , Xing Zan‐Yang , Reimer Ashton , Nishimura Yukitoshi , Hampton Don
Published: July 2021

Following substorm auroral onset, the active aurora region usually expands poleward toward the poleward auroral boundary. Such poleward expansion is often associated with a bulge region that expands westward and forms the westward travelling surge. In this study, we show all‐sky imager and Poker Flat Advanced Modular Incoherent Scatter Radar observations of two surge events to investigate the relationship between the surge and ionospheric flows that likely have polar cap origin. For both events, we observe auroral streamers, with an adjacent flow channel consisting of decreased density and low electron temperature plasma flowing equatorward. This flow channel appears to impinge and lead/feed surge formation, and to stay connected to the surge as it moves westward. Also, for both events, streamer observations indicate that, following initial surge development, similar flows led to explosive surge enhancements. The observation that the streamers are connected to the auroral polar boundary and that the flow channels consisted of low density, low electron temperature plasma suggests the possibility that the impinging plasma came from the polar cap. For both events, the altitude variations of F region plasma within the surges are related with aurora emission and the poleward/equatorward flow, and the surges develop strong auroral streamers that initiate along the poleward auroral boundary when contacted with the flow. These results suggest that the flow of polar cap origin, which maps to underlying processes in the magnetotail, may play a crucial role in auroral surges by feeding low entropy plasma into surge initiation and development, and also playing an important role in the dynamics within a surge.
Linking Intraplate Volcanism to Lithospheric Structure and Asthenospheric Flow
Authors: Duvernay Thomas , Davies D. Rhodri , Mathews Christopher R. , Gibson Angus H. , Kramer Stephan C.
Published: July 2021

Several of Earth's intraplate volcanic provinces are hard to reconcile with the mantle plume hypothesis. Instead, they exhibit characteristics that are more compatible with shallower processes that involve the interplay between uppermost mantle flow and the base of Earth's heterogeneous lithosphere. The mechanisms most commonly invoked are edge‐driven convection (EDC) and shear‐driven upwelling (SDU), both of which act to focus upwelling flow and the associated decompression melting adjacent to steps in lithospheric thickness. In this study, we undertake a systematic numerical investigation, in both 2‐D and 3‐D, to quantify the sensitivity of EDC, SDU, and the associated melting to key controlling parameters. Our simulations demonstrate that the spatio‐temporal characteristics of EDC are sensitive to the geometry and material properties of the lithospheric step, in addition to the magnitude and depth‐dependence of upper‐mantle viscosity. These simulations also indicate that asthenospheric shear can either enhance or reduce upwelling velocities and the associated melting, depending upon the magnitude and orientation of flow relative to the lithospheric step. When combined, such sensitivities explain why step changes in lithospheric thickness, which are common along cratonic edges and passive margins, only produce volcanism at isolated points in space and time. Our predicted trends of melt production suggest that, in the absence of potential interactions with mantle plumes, EDC and SDU are viable mechanisms only for Earth's shorter‐lived, lower‐volume intraplate volcanic provinces.
Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue
Authors: Park Sujeong , Song Jinsoo , Baek In-Jeoung , Jang Kyu Yun , Han Chang Yeob , Jun Dae Won , Kim Peter K. , Raught Brian , Jin Eun-Jung
Published: July 2021

In this study, we hypothesized that deregulation in the maintenance of the pool of coenzyme A (CoA) may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Specific deletion of Acot12 (Acot12−/−), the major acyl-CoA thioesterase, induced the accumulation of acetyl-CoA and resulted in the stimulation of de novo lipogenesis (DNL) and cholesterol biosynthesis in the liver. KEGG pathway analysis suggested PPARα signaling as the most significantly enriched pathway in Acot12−/− livers. Surprisingly, the exposure of Acot12−/− hepatocytes to fenofibrate significantly increased the accumulation of acetyl-CoA and resulted in the stimulation of cholesterol biosynthesis and DNL. Interaction analysis, including proximity-dependent biotin identification (BioID) analysis, suggested that ACOT12 may directly interact with vacuolar protein sorting-associated protein 33A (VPS33A) and play a role in vesicle-mediated cholesterol trafficking and the process of lysosomal degradation of cholesterol in hepatocytes. In summary, in this study, we found that ACOT12 deficiency is responsible for the pathogenesis of NAFLD through the accumulation of acetyl-CoA and the stimulation of DNL and cholesterol via activation of PPARα and inhibition of cholesterol trafficking.
Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth
Authors: Rozovsky Renata , Versace Amelia , Bonar Lisa K. , Bertocci Michele , Ladouceur Cecile D. , Fournier Jay , Monk Kelly , Abdul-waalee Halimah , Bebko Genna , Hafeman Danella , Sakolsky Dara , Goldstein Tina , Birmaher Boris , Phillips Mary L.
Published: July 2021

Bipolar disorder (BD) is highly heritable. Identifying objective biomarkers reflecting pathophysiological processes predisposing to, versus protecting against BD, can help identify BD risk in offspring of BD parents. We recruited 21 BD participants with a first-degree relative with BD, 25 offspring of BD parents, 27 offspring of comparison parents with non-BD psychiatric disorders, and 32 healthy offspring of healthy parents. In at-risk groups, 23 had non-BD diagnoses and 29, no Axis-I diagnoses(healthy). Five at-risk offspring who developed BD post scan(Converters) were included. Diffusion imaging(dMRI) analysis with tract segmentation identified between-group differences in the microstructure of prefrontal tracts supporting emotional regulation relevant to BD: forceps minor, anterior thalamic radiation(ATR), cingulum bundle(CB), and uncinate fasciculus(UF). BD participants showed lower fractional anisotropy (FA) in the right CB (anterior portion) than other groups (q < 0.05); and in bilateral ATR (posterior portion) versus at-risk groups (q < 0.001). Healthy, but not non-BD, at-risk participants showed significantly higher FA in bilateral ATR clusters than healthy controls (qs < 0.05). At-risk groups showed higher FA in these clusters than BD participants (qs < 0.05). Non-BD versus healthy at-risk participants, and Converters versus offspring of BD parents, showed lower FA in the right ATR cluster (qs < 0.05). Low anterior right CB FA in BD participants versus other groups might result from having BD. High bilateral ATR FA in at-risk groups, and in healthy at-risk participants, versus healthy controls might protect against BD/other psychiatric disorders. Absence of elevated right ATR FA in non-BD versus healthy at-risk participants, and in Converters versus non-converter offspring of BD parents, might lower protection against BD in at-risk groups.
Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection
Authors: Liu Yaobin , Mukherjee Rukmini , Bonn Florian , Colby Thomas , Matic Ivan , Glogger Marius , Heilemann Mike , Dikic Ivan
Published: July 2021

SidE family of Legionella effectors catalyze non-canonical phosphoribosyl-linked ubiquitination (PR-ubiquitination) of host proteins during bacterial infection. SdeA localizes predominantly to ER and partially to the Golgi apparatus, and mediates serine ubiquitination of multiple ER and Golgi proteins. Here we show that SdeA causes disruption of Golgi integrity due to its ubiquitin ligase activity. The Golgi linking proteins GRASP55 and GRASP65 are PR-ubiquitinated on multiple serine residues, thus preventing their ability to cluster and form oligomeric structures. In addition, we found that the functional consequence of Golgi disruption is not linked to the recruitment of Golgi membranes to the growing Legionella-containing vacuoles. Instead, it affects the host secretory pathway. Taken together, our study sheds light on the Golgi manipulation strategy by which Legionella hijacks the secretory pathway and promotes bacterial infection.
Laparoscopic intraarterial catheterization with selective ICG fluorescence imaging in colorectal surgery
Authors: Heiliger Christian , Piecuch Jerzy , Frank Alexander , Andrade Dorian , von Ehrlich-Treuenstätt Viktor , Evtimova Dobromira , Kühn Florian , Werner Jens , Karcz Konrad
Published: July 2021

The quality of mesorectal resection is crucial for resection in rectal cancer, which should be performed by laparoscopy for better outcome. The use of indocyanine green (ICG) fluorescence is now routinely used in some centers to evaluate bowel perfusion. Previous studies have demonstrated in animal models that selective intra-arterial ICG staining can be used to define and visualize resection margins in rectal cancer. In this animal study, we investigate if laparoscopic intra-arterial catheterization is feasible and the staining of resection margins when performing total mesorectal excision with a laparoscopic medial to lateral approach is possible. In 4 pigs, laparoscopic catheterization of the inferior mesenteric artery (IMA) is performed using a seldinger technique. After a bolus injection of 10 ml ICG with a concentration of 0.25 mg/ml, a continuous intra-arterial perfusion was established at a rate of 2 ml/min. The quality of the staining was evaluated qualitatively. Laparoscopic catheterization was possible in all cases, and the average time for this was 30.25 ± 3.54 min. We observed a significant fluorescent signal in all areas of the IMA supplied, but not in other parts of the abdominal cavity or organs. In addition, the mesorectum showed a sharp border between stained and unstained tissue. Intraoperative isolated fluorescence augmentation of the rectum, including the mesorectum by laparoscopic catheterization, is feasible. Inferior mesenteric artery catheterization and ICG perfusion can provide a fluorescence-guided roadmap to identify the correct plane in total mesorectal excision, which should be investigated in further studies.
From the first touch to biofilm establishment by the human pathogen Candida glabrata: a genome-wide to nanoscale view
Authors: Cavalheiro Mafalda , Pereira Diana , Formosa-Dague Cécile , Leitão Carolina , Pais Pedro , Ndlovu Easter , Viana Romeu , Pimenta Andreia I. , Santos Rui , Takahashi-Nakaguchi Azusa , Okamoto Michiyo , Ola Mihaela , Chibana Hiroji , Fialho Arsénio M. , Butler Geraldine , Dague Etienne , Teixeira Miguel C.
Published: July 2021

Candida glabrata is an opportunistic pathogen that adheres to human epithelial mucosa and forms biofilm to cause persistent infections. In this work, Single-cell Force Spectroscopy (SCFS) was used to glimpse at the adhesive properties of C. glabrata as it interacts with clinically relevant surfaces, the first step towards biofilm formation. Following a genetic screening, RNA-sequencing revealed that half of the entire transcriptome of C. glabrata is remodeled upon biofilm formation, around 40% of which under the control of the transcription factors CgEfg1 and CgTec1. Using SCFS, it was possible to observe that CgEfg1, but not CgTec1, is necessary for the initial interaction of C. glabrata cells with both abiotic surfaces and epithelial cells, while both transcription factors orchestrate biofilm maturation. Overall, this study characterizes the network of transcription factors controlling massive transcriptional remodelling occurring from the initial cell-surface interaction to mature biofilm formation.
Open-air printing of Cu2O thin films with high hole mobility for semitransparent solar harvesters
Authors: Sekkat Abderrahime , Nguyen Viet Huong , Masse de La Huerta César Arturo , Rapenne Laetitia , Bellet Daniel , Kaminski-Cachopo Anne , Chichignoud Guy , Muñoz-Rojas David
Published: July 2021

Cu2O is a promising p-type semiconductor for low-cost photovoltaics and transparent optoelectronics. However, low-cost and low-temperature fabrication of Cu2O films with good transport properties remains challenging, thus limiting their widespread adoption in devices. Here, we report Cu2O thin films of 20–80 nm thickness with hole mobility up to 92 cm2V−1s−1 using atmospheric-pressure spatial atomic layer deposition at temperatures below 260 °C, from a copper (I) hexafluoro-2,4-pentanedionate cyclooctadiene precursor. Raman spectroscopy indicates the presence of copper split vacancies and shows that the high hole mobility can be correlated to a low concentration of shallow acceptor defects. The optical bandgap of deposited films can be tuned between 2.08 eV and 2.5 eV, depending on the deposition temperature. All-oxide semitransparent Cu2O/ZnO solar harvesters are fabricated, showing efficiency values comparable to devices that incorporate much thicker Cu2O layers. Our work provides a promising approach towards cost-efficient, all-oxide solar harvesters, and for other (opto)electronic devices.
P3-Type K0.45Co1/12Mg1/12Mn5/6O2 as a superior cathode material for potassium-ion batteries with high structural reversibility ensured by Co–Mg Co-substitution
Authors: Liang Jinji , Lin Chenhan , Meng Xiangcong , Liang Min , Lai Jie , Zheng Xuhong , Huang Quanzhuang , Liu Liying , Shi Zhicong
Published: July 2021

P3-K0.45Co1/12Mg1/12Mn5/6O2 exhibits highly reversible single-phase structural evolution during the K+ deintercalation/intercalation. On the contrast, the pristine K0.45MnO2 electrode experiences incompletely reversible structural variation from a P′3 to P3 phase.
The anti-tumor effects of the combination of microwave hyperthermia and lobaplatin against breast cancer cells in vitro and in vivo
Authors: Li Xiaohu , Zhang Xin , Khan Inam Ullah , Guo Nina N. , Wang Bing , Guo Yifeng , Xiao Bufan , Zhang Yueshan , Chu Yimin , Chen Junsong , Guo Fang
Published: July 2021

Background: Breast cancer is the main lethal disease among females. The combination of lobaplatin and microwave hyperthermia plays a crucial role in several kinds of cancer in the clinic, but its possible mechanism in breast cancer has remained indistinct.

Methods: Mouse models were used to detect breast cancer progression. Cell growth was explored with MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphonyl)-2H-tetrazolium) and colony formation assays. Cell migration and invasion were investigated with a transwell assay. Cell apoptosis was probed with flow cytometry. The expression of apoptosis-associated proteins was examined with Western blots.

Result: Combination treatment decreased breast cancer cell viability, colony formation, cell invasion and metastasis. In addition, the treatment-induced breast cancer cell apoptosis and autophagy, activated the c-Jun N-terminal kinase (JNK) signaling pathway, suppressed the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway, and down-regulated IAP and Bcl-2 family protein expression.

Conclusion: These results indicate that lobaplatin is an effective breast cancer anti-tumor agent. Microwave hyperthermia was a useful adjunctive treatment. Combination treatment was more efficient than any single therapy. The possible mechanism for this effect was mainly associated with activation of the JNK signaling pathway, inactivation of the AKT/mTOR signaling pathway and down-regulation of the Bcl-2 and IAP families.
Full-length transcriptome assembly of andrias davidianus (amphibia: caudata) skin via hybrid sequencing
Authors: Bai Yu , Meng Yonglu , Luo Jianlin , Wang Hui , Li Guoyong , Li Can
Published: July 2021

The Chinese giant salamander, Andrias davidianus, is the largest amphibian species in the world; it is thus an economically and ecologically important species. The skin of A. davidianus exhibits complex adaptive structural and functional adaptations to facilitate survival in aquatic and terrestrial ecosystems. Here, we report the first full-length amphibian transcriptome from the dorsal skin of A. davidianus, which was assembled using hybrid sequencing and the PacBio and Illumina platforms. A total of 153,038 transcripts were hybrid assembled (mean length of 2039 bp and N50 of 2172 bp), and 133,794 were annotated in at least one database (nr, Swiss-Prot, KEGG, KOGs, GO, and nt). A total of 58,732, 68,742, and 115,876 transcripts were classified into 24 KOG categories, 1903 GO term categories, and 46 KEGG pathways (level 2), respectively. A total of 207,627 protein-coding regions, 785 transcription factors, 27,237 potential long non-coding RNAs, and 8299 simple sequence repeats were also identified. The hybrid-assembled transcriptome recovered more full-length transcripts, had a higher N50 contig length, and a higher annotation rate of unique genes compared with that assembled in previous studies using next-generation sequencing. The high-quality full-length reference gene set generated in this study will help elucidate the genetic characteristics of A. davidianus skin and aid the identification of functional skin proteins.
The view of microbes as energy converters illustrates the trade-off between growth rate and yield
Authors: Wilken St. Elmo , Frazão Victor Vera , Saadat Nima P. , Ebenhöh Oliver
Published: July 2021

The application of thermodynamics to microbial growth has a long tradition that originated in the middle of the 20th century. This approach reflects the view that self-replication is a thermodynamic process that is not fundamentally different from mechanical thermodynamics. The key distinction is that a free energy gradient is not converted into mechanical (or any other form of) energy but rather into new biomass. As such, microbes can be viewed as energy converters that convert a part of the energy contained in environmental nutrients into chemical energy that drives self-replication. Before the advent of high-throughput sequencing technologies, only the most central metabolic pathways were known. However, precise measurement techniques allowed for the quantification of exchanged extracellular nutrients and heat of growing microbes with their environment. These data, together with the absence of knowledge of metabolic details, drove the development of so-called black-box models, which only consider the observable interactions of a cell with its environment and neglect all details of how exactly inputs are converted into outputs. Now, genome sequencing and genome-scale metabolic models (GEMs) provide us with unprecedented detail about metabolic processes inside the cell. However, mostly due to computational complexity issues, the derived modelling approaches make surprisingly little use of thermodynamic concepts. Here, we review classical black-box models and modern approaches that integrate thermodynamics into GEMs. We also illustrate how the description of microbial growth as an energy converter can help to understand and quantify the trade-off between microbial growth rate and yield.