bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the cost-effectiveness of early diagnosis and pharmacotherapy of pulmonary arterial hypertension
Authors: Даценко І. С.
Published: March 2023

Over the past decades, health policy makers have focused on early diagnosis to introduce targeted and innovative treatments. Early diagnosis of pulmonary arterial hypertension (PAH) is associated with improved long-term survival, so screening high-risk groups is a reasonable strategy to improve outcomes in PAH treatment.

Today, screening is an important part of preventive medicine, with the goal of detecting disease at an early and pre-symptomatic stage.

All healthcare systems have limited resources and face opportunity costs; this means that any investment in a screening tool will come at the expense of other healthcare services, to the detriment of those patients who would otherwise be treated.

By recognizing opportunity costs, health systems can require that health interventions be both clinically and cost-effective to be considered for implementation.

The objective of the paper –to conduct a cost-effectiveness analysis of early diagnosis and pharmacotherapy of pulmonary arterial hypertension.

Our analysis of the cost-effectiveness of early diagnosis and pharmacotherapy of pulmonary arterial hypertension is based on a cost‒utility model that estimates patient survival, which is significantly improved by reducing the delay in diagnosis of PAH and indicates the prevention of premature death of undiagnosed patients. The analysis of input data was conducted using systematic review, documentary, informational and graphical research methods.

The results of the study showed that the choice of the target population and the level of diagnostic coverage of this risk group is critical for the cost-effectiveness of the implementation of PAH diagnostic screening. A decrease in these indicators leads to a decrease in the maximum allowable cost of diagnostic screening, and thus to a decrease in its profitability in real medical practice. The introduction of new treatments and the corresponding increase in the utility of PAP detection have the most positive effect on the profitability of the PAP diagnostic screening program.

This cost-effectiveness analysis is the first attempt to evaluate the economic value of reducing the delay in PAH diagnosis compared to its benefits to the health care system and society as a whole.
Enhancing Cancer Treatment and Understanding Through Clustering of Gene Responses to Categorical Stressors
Authors: El Hadi Christopher , Hilal George , Aoun Rita
Published: March 2023

Cancer cells have unique metabolic activity in the glycolysis pathway compared to normal cells, which allows them to sustain their growth and proliferation. Therefore, inhibiting glycolytic pathways may provide a promising therapeutic approach to cancer treatment. In this first-of-its-kind study, we analyzed the genetic responses of cancer cells to stressors, particularly drugs that target the glycolysis pathway. Gene expression data for experiments on different types of cancer cells were retrieved from the Gene Expression Omnibus and expression fold-change was then clustered after dimensionality reduction. We identified four response clusters, the first and third are affected the most by anti-glycolytic drugs, consisting mainly of squamous and mesenchymal tissues, showing higher mitotic inhibition and apoptosis. Drugs acting on several glycolytic targets at once resulted in such responses. The second and fourth clusters were relatively unaffected by the treatments, succumbing the least to glycolysis inhibitors. These clusters are mainly gynecological and hormone-sensitive, with drugs acting on hexokinases mainly inducing this response. This study highlights the importance of analyzing the molecular states of cancer cells to identify potential targets for personalized cancer treatments and to improve our understanding of the disease.
Knowledge, Exposure and Practice of Health Care Workers Regarding Emergency Airway Management in a Tertiary Care Centre of West Bengal: Questionnaire-Based Analytical Study
Authors: Rahaman Md Abdur , Guha Anurup , Sagar K Geeth
Published: March 2023

Background: Endotracheal intubation is an essential resuscitative procedure in the emergency setting, to maintain a patent airway. In our day-to-day practice at a tertiary care centre calls for intubation remain in quite a demand. As we all know in the emergency setting we first advocate maintaining the so-called A (airway), B(breathing) and C(circulation) and this is where lies the importance of intubation.

Objective: The study was done to assess the knowledge, competency, and exposure regarding emergency airway management among healthcare workers in this region of West Bengal which caters to patients from the Mahananda Basin, in particular, Malda.

Methodology: A questionnaire-based cross-sectional study was conducted. The study tool was a standard questionnaire containing 14 questions, which was developed to assess the knowledge, exposure, and practice of the study group in a Tertiary Care Centre of West Bengal.

Results: the questionnaire based analytical study revealed gross lack of knowledge among caregivers regarding management of airway during emergency situations.

Inference: Basic knowledge in terms of theory seems to prevail among almost all the participants but they lack the congruity between knowledge and exposure, hence an interactive curriculum should be designed to train the target groups in order to avoid the catastrophe seen during emergency situations.
INNOVATIVE COMPONENT OF FINANCIAL SECURITY OF ENTERPRISES
Authors: Тітенко Зоя
Published: March 2023

Innovations play an important role in the development of both the economy as a whole and individual enterprises in particular. Therefore, the issue of ensuring innovative development and finding financial resources that will facilitate the implementation of innovations is becoming more and more urgent. In modern conditions, in order to ensure the proper level of financial security of business entities, it is necessary to implement the latest technologies that will contribute to increasing the competitiveness of enterprises, both on the domestic and foreign markets. The purpose of the article is to study the prerequisites for ensuring the appropriate level of innovative development of enterprises, as one of the factors for ensuring the appropriate level of their financial security in today's difficult conditions. The article defines the main factors of the innovative component of financial security: innovative development, innovative potential and innovative risks. The importance of their consideration to ensure the appropriate level of financial security has been proven. The author investigated the essence of the innovative development category and determined its direct impact on the level of financial security of enterprises. In the difficult conditions of conducting economic activity at present, the issue of increasing innovation potential is becoming more and more urgent. The author focuses attention on the factors of the external and internal environment that affect the innovative potential of the enterprise. The article offers the author's interpretation of the innovative potential of enterprises as a component of its financial security. It has been proven that to ensure effective innovative development, it is necessary to strictly follow the mechanism of its formation.It provides for the presence of certain constituent elements, in particular: a clear definition of the set goal, in accordance with which the tasks must be developed, throughout the study, an analysis of the implementation of the set tasks must take place, so that the main goal of the study is achieved. It was determined that threats and risks have a significant impact on innovative development, which necessitates their constant monitoring in order to help minimize them.
ЕВОЛЮЦІЯ КОНЦЕПЦІЇ ВІД CМАРТ-ОСВІТИ ДО СМАРТ-ЕКОНОМІКИ ТА СМАРТ-БІЗНЕСУ
Authors: Воронкова Валентина , Нікітенко Віталіна , Метеленко Наталя
Published: March 2023

Актуальність дослідження у тому, що поглиблений розвиток глобалізації сприяв трансформації та реформуванню економічної системи, що сприяло посиленню соціальної трансформації та глибоких змін у системі освіти, економіки, бізнесу. З розвитком і застосуванням цифрових технологій, таких як хмарні обчислення, штучний інтелект і блокчейн, цифрові зміни та хмарний розвиток стали світовою темою. Цифровізація як глобальна тенденція розвитку стала центром розвитку в усіх країнах. Метою дослідження є теоретичні і практичні виміри еволюції концепції від cмарт-освіти до смарт-економіки та смарт-бізнесу. Методологія дослідження – це застосування методів системного аналізу і синтезу, Agile-методології, системно-структурного та структурно-функціонального методів дозволили показати еволюцію концепції від cмарт-освіти до смарт-економіки та смарт-бізнесу, розкрити цифровізацію освіти, економіки і бізнесу, які перетворилася на нову вимогу адаптації до економічного та соціального розвитку, вирішення суперечності між соціальним розвитком і попитом і пропозицією талантів, а також підвищення соціальної продуктивності. У результаті дослідження здійснено конотацію «цифрової трансформації смарт-освіти»; з’ясовано економічні, соціальні та культурні чинники еволюції від смарт-освіти до смарт-економіки та смарт-бізнесу; сформовано модель цифрового бізнесу та умови його успішності; розроблено концепцію смарт-економіки та смарт-бізнесу у контексті нових викликів цифровізації і глобалізації Практичне значення дослідження у розробці концепції смарт-економіки зі штучним інтелектом, яка виступає чинник ефективності, сталості та гармонії, в яких домінують інновації, креативність, творчість.
ОГЛЯД МІЖНАРОДНИХ ТА ВІДЧИЗНЯНИХ СТАНДАРТІВ ОЦІНКИ ВАРТОСТІ БІЗНЕСУ В СИСТЕМІ ПРАВОВОГО РЕГУЛЮВАННЯ ОЦІНОЧНОЇ ДІЯЛЬНОСТІ
Authors: Корецька Ольга , Жихарєва Влада
Published: March 2023

Стаття присвячена актуальним питанням міжнародних та вітчизняних стандартів оцінки вартості бізнесу та системі правового регулювання оціночної діяльності цілісного майнового комплексу та бізнесу. У статті надається сутність поняття «бізнес», «підприємство», «цілісний майновий комплекс». Обґрунтовано доцільність використання саме поняття «бізнес» як в міжнародному законодавстві так і у вітчизняному. Розглянуто сутність основних методичних підходів до оцінки вартості цілісних майнових комплексів та бізнесу та порівняння їх основних елементів. Більш детально розглянуто метод дисконтування грошового потоку та розроблено алгоритм проведення оцінки вартості бізнесу. Доведено, що використання доходного та порівняльного підходів оцінки вартості в Україні ускладнює нерозвиненістю фінансових та фондових ринків.
ПОНЯТТЯ ТА ПОРЯДОК СКЛАДАННЯ ПОДАТКОВОЇ ЗВІТНОСТІ ПІДПРИЄМСТВ
Authors: Мачак Тетяна , Ткаченко Олександр , Дубина Олена
Published: March 2023

Стаття присвячена актуальним питанням формування та подання податкової звітності. Визначено значення та роль податкової звітності в системі бухгалтерської звітності підприємства. Проаналізовано основні класифікаційні ознаки податкової звітності. Встановлено порядок складання і строки подання різних форм податкової звітності до органів державної служби, визначено відповідальність за недотримання та порушення даного порядку. Визначено шляхи подання платниками податків податкової документації.
A COMPARATIVE STUDY ON LEGAL FRAMEWORKS ON RENEWABLE ENERGY IN MALAYSIA AND INDIA: TOWARDS THE COMMITMENTS UNDER THE PARIS AGREEMENT
Authors: Ghazali Farahdilah , Ansari Abdul Haseeb , Karim Ridoan
Published: March 2023

Climate change has always been an agenda for the international community, individually and collectively, due to global warming and unusual weather conditions. The International Renewable Energy Agency (IRENA) believes that the adequate deployment of clean energy can achieve the targets of the Paris Climate Change Agreement. Many countries have shown their commitment to decrease their carbon emission levels substantially, and they have done so by resorting to renewable energy sources. Renewable energy generation opens a viable door for climate change mitigation efforts. Both Malaysia and India are committed to fulfilling their obligation under the Paris Agreement. This comparative study evaluates the laws and policies related to renewable energy in Malaysia and India, as these countries progress towards their commitments under the Climate Change Convention (UNFCCC). This study operates under the comparative qualitative methodological framework and utilises secondary sources for analysis. Based on the comparative expositions, Malaysia can learn measures adopted by India to accelerate renewable energy development as well as to reduce greenhouse gas (GHG) emission, which will prove beneficial to the country as well as in order to comply with international conventions and agreements.
ASEAN-FTA Impact on Rubber and Crude Palm Oil Export: An Empirical Evidence from IMT Countries
Authors: Isnurhadi Isnurhadi , Bashir Abdul , Suhel Suhel
Published: March 2023

This study applies the gravity model to explore whether the establishment and the agreement of the ASEAN Free Trade Area (AFTA) have an impact on the export increase of rubber and crude palm oil commodity trade for the case ASEAN member countries namely, Indonesia-Malaysia-Thailand (IMT). The study uses time-series data, first for Indonesia using the period of 1996-2017 with trading partners as much as 21 countries for crude palm oil (CPO) commodity and 22 countries for rubber commodity. Secondly, the CPO export model for Malaysia using data during 1997-2017 with 23 trading partners countries. Thirdly, export rubber model for Thailand using a period of 1999-2017 with 16 trading partners countries. The estimate the Indonesian and Thailand export model for rubber commodity, and second, the same model also is estimated export CPO for the Indonesian and Malaysian. Generally, we found that the regression results it appears ASEAN member countries have not been fully benefited from the enactment of the AFTA, especially on the export of Indonesia's main commodities such as rubber and crude palm oil which destined for trading partners countries. As for the export of Thailand rubber and Malaysian crude palm oil, both countries are still relatively slightly better because the AFTA agreement has fully benefited. During the study period, the results of this study indicated that these three countries trade both commodities more intensely to the non-ASEAN countries
Vernadsky and Rubakin: Identity of bibliocultural interests and mentality
Authors: Stolyarov Y. N.
Published: March 2023

The prominent Russian scientists, Vladimir I. Vernadsky (1863–1945), whose 160-th anniversary we celebrate this year, and Nikolay A. (Nikolas) Rubakin (1862–1946), whose 160-th anniversary we celebrated last year, were both library workers and bibliographers. They both entered St. Petersburg Imperial University, the department for natural sciences of physics and mathemetics faculty, communicated closely when students, and maintained friends and scientific ties up to 1936. The cosmological and cosmographic ideas of Dmitry I. Mendeleev, their teacher, influenced them both. Like N. Rubakin, V. I. Vernadsky saw selfless service to the humankind as his supreme goal. In his studiesw of psychology, Rubakin came to the conclusion that human life passes at three levels, namely biological, social, and cosmical level. In his turn, Vladimir Vernadsky is among acknowledged adept of Russian cosmism and father of the teaching of noosphere. The humanitarian trend in Venradsky’s world outlook manifested as early in his life as did his interest in the natural sciences. He developed his strong humanist, social ethical ideals in his early years as the scientist and thinker. These two persons were both engaged in bibliographic work, synchronically for some period. Vladimir Vernadsky was among the founders of Moscow Commission for Home Reading of the Educational Department of the Society to Promote Technical Knowledge (1893); Nikolas Rubakin was a founder of the Department to Support Self-education at Petersburg Pedagogical Museum of Military Educational Institutions (1894). They both took the most active part in writing bibliographies of general and supplementary literature within the curricula of the two institutions. Vernadsky and Rubakin had their original attitude towards library work in the country. V. Vernadsky sent regularly scientific books and journals to Rubakin in Switzerland. Rubakin came into contact with Georgy, V. Vernadsky’s son, who was living in the U.S.Almost Vernadsky’s every scientific achievement and social merits were acknowledged officially, unlike N. Rubakin who had no academic honors at all. Nevertheless, their contribution to the Russian and world culture is of the same value
Digital services at the affiliate libraries of the Russian Academy of Sciences to provide information support of science (the case study of Pushchino Central Library)
Authors: Zakharova S. S.
Published: March 2023

The national strategy for Russian libraries up to the year 2030 was approved by the RF Government in 2021. The development vectors extend to every library in the country, including scientific and academic ones. The author reviews the library system of the Russian Academy of Sciences and evaluates the possibility to implement digital technologies. For this purpose, she analyzes the existing computerized information library systems in centralized library networks ( CLN). T he R AS l ibrary s ystem h as t he p otential t o i mprove i nformation support of research. The structure of the RAS library network replicates the regional and discipline-oriented organizational RAS structure. Based on the experience of Pushchino Central Library – department of the RAS Library for Natural Sciences, the author concludes that despite incongruous software, hardware and technology, the scientific libraries have the potential to improve library services to support research. Each library must support services demanded by its users and corresponding to their specific research goals
First Dominant Circulation of Influenza A/H3 among Patients with Acute Respiratory Tract Infections in a Tertiary Care Hospital in Dhaka 2022
Authors: Rahman Mizanur , Ayaz KFM , Islam Sadiqul , Hasan Nazmul , Rahim Rummana , Hasan Abu
Published: March 2023

The seasonal circulation of influenza viruses varies from year to year. We have retrospectively analyzed our hospital data of respiratory pathogens among patients of respiratory tract infections and extracted circulation of influenza viruses and characterized patients with influenza attended to a tertiary care hospital in Dhaka from July 2021 to September 2022. We have analyzed data of real-time reverse transcription polymerase chain reaction testing of respiratory panel done in QIAstatDx (Qiagen, Germany) using nasopharyngeal samples to identify the presence of influenza viruses and to determine the subtypes. A total of 547 patient’s data were analyzed in this study, with an influenza positivity rate of 15.62% in 2021 and 23.63% in 2022. We identified an exclusive circulation of influenza A/H3 viruses in 2022 while cocirculation of Influenza A (H1N1 pdm 09 – 10.15%, H3– 2.34%, A not subtyped – 2.34%) and influenza B (0.78%) was observed in 2021 in our cohort. Further, subtyping data showed that both Influenza A/H1N1 pdm09 and Influenza A/H3 was equally observed in influenza like illness (ILI) and severe acute respiratory infection (SARI) patients. This small study in our cohort warrants further elaborate investigation to know circulating influenza A subtyping in the country which may assist health care providers in making treatment decisions and hence, appropriate patient management.
J MEDICINE 2023; 24: 37-42
A Suspicious Skin Lesion: Sufferings of A Remittance Warrior
Authors: Reza Ishrat Binte , Ahasan HAM Nazmul , Prince SM Kawser Zafor
Published: March 2023

Tuberculosis verrucosa cutis (TVC) is a rare form of cutaneous tuberculosis. it is usually found as a solitary lesion but Extensive multifocal presentation is very rare. Here, we report this case of extensive, multifocal tuberculosis verrucosa cutis in a 36-year-old immunocompetent male patient in the absence of any primary tubercular focus.
J MEDICINE 2023; 24: 67-68
Identifying a more severe emergent COVID-19 variant using Emergency Departments’ routinely collected clinical measures
Authors: Nyinawingeri Adelaide , Staff Michael
Published: March 2023

Objective To determine whether a clinical scoring system (the mPRIEST score) could be used to identify an emerging coronavirus disease 2019 (COVID-19) variant with increased clinical severity. Design Cross sectional study comparing two time periods (Delta and Omicron waves). Setting Public Emergency Departments in Northern Sydney Local Health District. Participants Patients presenting during August 2021 (Delta wave) and January 2022 (Omicron wave) with confirmed COVID-19. Data on age, gender, temperature, heart rate, systolic blood pressure, respiratory rate, oxygen saturation and mental status were extracted from patients’ electronic medical records to assess clinical disease severity at presentation. Main outcome measures Modified Pandemic Respiratory Infection Emergency System Triage (mPRIEST) score calculated using routinely collected data. Results A sample of 262 records of COVID-19 positive patients presenting during the Delta and initial Omicron waves were reviewed with 205 having COVID-19 as their primary diagnosis. During the Delta wave 48.1% had scores above 4 compared to 35.1% for the Omicron wave (p = 0.03). The median score was also significantly higher for the Delta group (4 vs 3; p = 0.01). Hospitalisations, admissions to ICU and deaths during admission were higher among patients presenting during the Delta wave than among those presenting during the Omicron wave. Conclusion The mPRIEST score was significantly higher for patients for whom the predominant circulating variant was Delta than those for whom the predominant circulating variant was Omicron. This finding is consistent with international reporting of severity measured by hospital admission data and demonstrates the score’s possible ability to identify an emergent strain with higher morbidity and mortality.
Epidemiology of syphilis in the Nepean and Blue Mountains Local Health District between 1 October 2009 and 30 September 2019
Authors: Kakar Sheena R , Truman George , Thomas Jane , Jackson Eva YH
Published: March 2023

Background Syphilis is a nationally notifiable sexually transmitted infection (STI). Rates of syphilis notifications have been on the increase in Australia. Given these increases, we wanted to study the epidemiological trends of syphilis notifications in the Nepean Blue Mountain Local Health District (NBMLHD) over a ten-year period across different healthcare settings. Methods All syphilis notifications in residents in the NBMLHD in the ten-year period between 1 October 2009 and 30 September 2019 were included in the study. Separate analyses were performed for all syphilis notifications, as well as for infectious syphilis and for syphilis acquired > 2 years ago or of unknown duration. We described age distribution and demographic profile and risk factors of all syphilis notifications. Notification trends were studied and crude incidence rates were calculated. Notifications were stratified by stage of syphilis, sex, and geographical location. Results In the study duration, a total of 342 notifications of syphilis were received. Of these, 187 were infectious syphilis and 155 were related to infections acquired > 2 years ago and/or of unknown duration. The majority of notifications were in men: 281 (82%). Overall, syphilis notifications increased over the ten-year study period. The crude incidence rates for infectious syphilis were significantly higher in the second five-year period overall (7.78/100,000 population per year compared to 5.28/100,000 population per year; incidence rate ratio (IRR): 1.47; 95% confidence interval (95% CI): 1.10–1.97; p < 0.01), as well as for males (14.44/100,000 population per year compared to 9.7/100,000 population per year; IRR: 1.49; 95% CI: 1.09–2.03; p < 0.01). There were significant increases in syphilis notifications in males < 35 years of age, from 39 such notifications in the first five-year period (27.5% of all syphilis notifications in this period) to 83 notifications in the second five-year period (42.1% of all notifications in this period), p < 0.05. Conclusion In keeping with national trends, notifications in our study increased. Significant increases were noted in notifications among males under 35 years of age. This supports the continued investment in sexual health promotion activities aimed at young sexually active men. Expansion of screening activities to include women and older people would help detect any increase in cases in these groups. Increase in engagement with general practitioners will support them to provide opportunistic STI screens to sexually-active attendees. National screening recommendations remain applicable to this population.
Kohti reflektiivistä katsomuskasvatusta
Authors: Keränen-Pantsu Raili , Huttunen Rauno , Heikkinen Hannu L. T.
Published: March 2023

Tässä artikkelissa käsitellään reflektiivisyyttä katsomuskasvatuksen kontekstissa filosofisista ja teoreettisista näkökulmista. Katsomuskasvatus tulkitaan tässä laajasti: se kattaa elämänkatsomustiedon ja uskontojen opetuksen lisäksi kaiken kasvatuksen, joka tukee katsomuksen muodostumista ja identiteettityötä. Reflektiivinen katsomuskasvatus asettuu vastakohdaksi indoktrinatiiviselle kasvatukselle, jossa pyritään iskostamaan tietynlaiseen oppiin tai uskomusjärjestelmään perustuva ajattelutapa oppilaiden mieliin. Reflektiivisen katsomuskasvatuksen tarkoitus on antaa lapselle ja nuorelle välineitä määritellä identiteettiään ja maailmankuvaansa. Artikkelissa esitetään uusi reflektiivisen katsomuskasvatuksen malli, jossa sovelletaan indoktrinaation kriittistä teoriaa sekä identiteetin ja kriittisen reflektion käsitteitä. Mallin pohjalta ehdotetaan, että katsomusreflektiivinen kasvatus edellyttää sekä kasvattajan minäpositioon kohdistuvaa identiteettireflektiivisyyttä että yhteisöön ja siinä vallitseviin kasvatuskäytäntöihin kohdistuvaa käytäntöreflektiivisyyttä.
PENGARUH PEMBELAJARAN MENGGUNAKAN E-LEARNING TERHADAP PRESTASI AKADEMIK MAHASISWA PROGRAM STUDI PENDIDIKAN LUAR SEKOLAH FAKULTAS ILMU PENDIDIKAN DAN PSIKOLOGI UNDIKMA TAHUN AKADEMIK 2020/2021
Authors: Duiga Dea , Herlina Herlina
Published: March 2023

Abstract (English)            To what extent is the Effect of Learning Using E-Lerning on Student Academic Achievement of the Out-of-School Education Study Program, Faculty of Education and Psychology, Mandalika University of Education. The subjects of this study were students of the out-of-school education study program, the Faculty of Education and Psychology, Mandalika University of Education, then the method of determining the subjects in this study was a population study because the number of subjects was less than 100 people but only 12 people. The data collection method used in this research is questionnaire as the main method, observation and documentation. The data analysis technique used is the t-test statistical formula. The results of the study show that there is an influence on the development of pretest and posttest skills seen in students. This is reinforced by the results of the pretest calculations which produce a score of 7.10 and a posttest of 7.44. This means that the null hypothesis (H0) is rejected while (H1) is accepted. Based on the results of these calculations, it can be said that the Effect of Learning Using E-Lerning on Student Academic Achievement of the Out-of-School Education Study Program, Faculty of Education and Psychology, Mandalika University of Educationkey Words : the effect of E-learning, the difference between Pretest and Posttest.Sejauh mana pengaruh pembelajaran menggunakan e-lerning terhadap prestasi akedemoik Mahasiswa Program Studi Pendidikan Luar Sekolah. Subjek penelitian ini adalah mahasiswa program studi pendidikan luar sekolah fakultah ilmu pendidikan dan psikologi universitas pendidikan mandalika, kemudian metode penentuan subjek pada penelitian ini adalah studi populasi karna jumlah subjek kurang dari 100 orang melainkan hanya 12 orang. Metode pengumpulan data yang digunakan dalam penelitian ini yaitu Angket sebagai metode utama, observsasi dan dokumentasi. Teknik analisis data yang digunakan yaitu rumus statistic t-test. Dari hasil penelitian menunjukkan bahwa ada  pengaruh  pengembangan keterampilan  pretest dan  posttest  yang  terlihat pada mahasiswa.Hal ini diperkuat dari hasil perhitungan pretest yang menghasilkan nilai 7,10 dan posttest 7,44. Hal ini berarti bahwa hipotesis nol (H0) ditolak sedangkan (H1) diterima. Berdasarkan dari hasil perhitungan tersebut bisa dikatakan bahwa Pengaruh Pembelajaran Menggunakan E-Lerning Terhadap Prestasi Akademik Mahasiswa Program Studi Pendidikan Luar Sekolah Fakultas Ilmu Pendidikan dan Psikologi Universitas Pendidikan Mandalika ada peningkatan.Kata Kunci: pengaruh E-lerning, perbedaan Pretest dan Posttest..
PENINGKATAN MINAT BELAJAR DENGAN MENGGUNAKAN MEDIA GAMBAR PADA MATA PELAJARAN IPS SISWA KELAS IV SD HADI SAKTI TAHUN PELAJARAN 2022/2023
Authors: Kartiani Baiq Sarlita , Maulana Lalu Paozan , Hadi M Samsul , Jaswandi Lalu
Published: March 2023

Penelitian ini dilakukan berdasarkan kondisi yang terjadi di SD HADI SAKTI, dimana minat belajar siswa masih sangat rendah pada mata pelajaran IPS dikarenakan metode pembelajaran yang kurang tepat. Penelitian ini bertujuan untuk mengetahui peningkatan minat belajar pada siswa kelas IV SD Hadi Sakti melalui media gambar pada mata pelajaran IPS. Jenis penelitian ini adalah penelitian tindakan kelas (PTK). Pengumpulan data dilakukan menggunakan metode observasi. Hasil penelitian menunjukkan bahwa terdapat peningkatan minat belajar siswa pada siklus I sebesar 70% menjadi 95% pada siklus II. Sehingga, dapat dikatakan bahwa penggunaan media gambar dalam proses pembelajaran dapat meningkatkan minat belajar siswa kelas 4 SD Hadi Sakti.Kata kunci: Minat Belajar, Media Gambar, IPSThis research was conducted based on the conditions that occurred at SD HADI SAKTI, where students' interest in learning was still very low in social studies subjects due to inappropriate learning methods. The purpose of this study was to determine the increase in learning interest of fourth grade students at SD Hadi Sakti through media images on social studies subjects. This type of research is classroom action research (CAR). Data collection was carried out using the observation method. The results showed that there was an increase in students' learning interest in cycle I by 70% and cycle II by 95%. So, it can be said that the use of media images can increase the learning interest of grade 4 SD Hadi Sakti students.Keywords: Interest in Learning, Image Media, IPS
8.Yüzyıl Avrupasında Hristiyan Din Adamlarına Talimatlar (Karolı Magnı Capıtulare Prımum Örneği)
Authors: GENÇ Özlem
Published: March 2023

Orta Çağ Avrupası Hristiyanlığın en yoğun yaşandığı yerlerden biridir. Batı Roma`nın yıkılışından yaklaşık 10. yüzyıla kadar süren erken dönemde, geç döneme benzer bir dini cemaat yapılanması yoktur. Bunun yerine dindar halkı yönlendiren yerel din adamları vardır. Onların kontrolünü sağlayanlar ise bağlı bulundukları piskoposlardır. Bu piskoposlar ya da sivil yöneticilerin kendi bölgelerindeki din adamlarına talimat iletme yollarından biri capitularia denen kararnamelerdir. Bunlar aynı zamanda her iki tarafın katılımıyla gerçekleştirilen meclislerde alınan kararlardır. Çalışmamıza konu ettiğimiz kararname ise son derece dindar bir Frank lider olan Şarlman`ın tahta çıktığında yayımladığı ilk kararnamedir ve din adamlarına talimatlar içermektedir. Bu talimatlar incelendiğinde din adamlarının özel hayatları, halen süren pagan gelenekler, piskopos onayı, din adamlarının yargılanmaları, verilen cezalar, denetlenmeleri, uzak durmaları gereken dünyevi aktiviteler gibi pek çok konuda değerli bilgiler edinilmektedir. Ayrıca din adamlarının çok çeşitli görev ve sorumlulukları olduğu, bahsi geçen dönemin hem dini hem sivil hayatında çok etkili oldukları anlaşılmaktadır.
Assessing the performance of ChatGPT in answering questions regarding cirrhosis and hepatocellular carcinoma
Authors: Yeo Yee Hui , Samaan Jamil S. , Ng Wee Han , Ting Peng-Sheng , Trivedi Hirsh , Vipani Aarshi , Ayoub Walid , Yang Ju Dong , Liran Omer , Spiegel Brennan , Kuo Alexander
Published: March 2023

Background/Aims: Patients with cirrhosis and hepatocellular carcinoma (HCC) require extensive and personalized care to improve outcomes. ChatGPT (Generative Pre-trained Transformer), a large language model, holds the potential to provide professional yet patient-friendly support. We aimed to examine the accuracy and reproducibility of ChatGPT in answering questions regarding knowledge, management, and emotional support for cirrhosis and HCC.Methods: ChatGPT’s responses to 164 questions were independently graded by two transplant hepatologists and resolved by a third reviewer. The performance of ChatGPT was also assessed using two published questionnaires and 26 questions formulated from the quality measures of cirrhosis management. Finally, its emotional support capacity was tested.Results: We showed that ChatGPT regurgitated extensive knowledge of cirrhosis (79.1% correct) and HCC (74.0% correct), but only small proportions (47.3% in cirrhosis, 41.1% in HCC) were labeled as comprehensive. The performance was better in basic knowledge, lifestyle, and treatment than in the domains of diagnosis and preventive medicine. For the quality measures, the model answered 76.9% of questions correctly but failed to specify decision-making cut-offs and treatment durations. ChatGPT lacked knowledge of regional guidelines variations, such as HCC screening criteria. However, it provided practical and multifaceted advice to patients and caregivers regarding the next steps and adjusting to a new diagnosis.Conclusions: We analyzed the areas of robustness and limitations of ChatGPT’s responses on the management of cirrhosis and HCC and relevant emotional support. ChatGPT may have a role as an adjunct informational tool for patients and physicians to improve outcomes.
Toxicity of Bisphenol A and its Replacements in the Mice Leydig Cells In Vitro
Authors: JAMBOR T , KNIZATOVA N , GREIFOVA H , KOVACIK A , LUKAC N
Published: March 2023

The aim of the study was to examine the potential impacts of bisphenol A (BPA) and its analogues BPB, BPF, and BPS on mice TM3 Leydig cells, with respect to basal cell viability parameters such as metabolic activity, cell membrane integrity, and lysosomal activity after 48-h exposure. In addition, monitoring of potential bisphenol´s actions included evaluation of ROS production and gap junctional intercellular communication (GJIC) complemented by determination of testosterone secretion. Obtained results revealed significant inhibition in mitochondrial activity started at 10 µg/ml of bisphenols after 48-h exposure. Cell membrane integrity was significantly decreased at 5 µg/ml of BPA and BPF and 10, 25, and 50 µg/ml of BPA and BPS. The lysosomal activity was significantly affected at 10, 25, and 50 µg/ml of applied bisphenols. A significant overproduction of ROS was recorded mainly at 5 and 10 µg/ml of tested compounds. In addition, significant inhibition of GJIC was observed at 5 µg/ml of BPB followed by a progressive decline at higher applied doses. In the case of testosterone production, a significant decline was confirmed at 10, 25 and 50 µg/ml.
Treating Inadequately Controlled Asthma: Exploring the Potential of Phenotype-Targeted Therapy
Authors: Mughal Tabasum
Published: March 2023

Asthma is inadequately treated with the current standard of care. This session aimed to explore the potential of a phenotype-targeted approach to asthma management, which would allow a more tailored approach to treatment and result in better clinical outcomes for difficult-to-treat patients. Evidence was presented indicating that eosinophils play an important role in the pathogenesis of asthma. The importance of anti-interleukin (IL)-5 therapies, with the focus on therapies currently in development and their potential clinical benefit for the eosinophilic asthma phenotype, was also explored.
Reciprocity as an Argument for Prioritizing Health Care Workers for the COVID-19 Vaccine
Authors: Jølstad Borgar , Solberg Carl Tollef
Published: March 2023

During the recent debates on whether to prioritize health care workers for COVID-19 vaccines, two main lines of arguments emerged: one centered on maximizing health and one centered on reciprocity. In this article, we scrutinize the argument from reciprocity. The notions of fittingness and proportionality are fundamental for the act of reciprocating. We consider the importance of these notions for various arguments from reciprocity, showing that the arguments are problematic. If there is a plausible argument for reciprocity during the pandemic, this is most likely one that centers on the risk that health care workers take on while working. We argue that the scope of this argument is not plausibly extended only to health care workers. Other essential workers at risk are in the position to make the same arguments. We also argue that there is no compelling argument from reciprocity that makes reciprocating with vaccines, rather than by other means, necessary. Furthermore, allocating vaccines based on reciprocity will conflict with utility-maximizing. Given the weak state of the arguments, overriding concerns for utility seem unreasonable.
Joint visualization of seasonal influenza serology and phylogeny to inform vaccine composition
Authors: Lee Jover , Hadfield James , Black Allison , Sibley Thomas R. , Neher Richard A. , Bedford Trevor , Huddleston John
Published: March 2023

Seasonal influenza vaccines must be updated regularly to account for mutations that allow influenza viruses to escape our existing immunity. A successful vaccine should represent the genetic diversity of recently circulating viruses and induce antibodies that effectively prevent infection by those recent viruses. Thus, linking the genetic composition of circulating viruses and the serological experimental results measuring antibody efficacy is crucial to the vaccine design decision. Historically, genetic and serological data have been presented separately in the form of static visualizations of phylogenetic trees and tabular serological results to identify vaccine candidates. To simplify this decision-making process, we have created an interactive tool for visualizing serological data that has been integrated into Nextstrain’s real-time phylogenetic visualization framework, Auspice. We show how the combined interactive visualizations may be used by decision makers to explore the relationships between complex data sets for both prospective vaccine virus selection and retrospectively exploring the performance of vaccine viruses.
CDK4/6 inhibitor resistance in estrogen receptor positive breast cancer, a 2023 perspective
Authors: Zhou Fiona H. , Downton Teesha , Freelander Allegra , Hurwitz Joshua , Caldon C. Elizabeth , Lim Elgene
Published: March 2023

CDK4/6 inhibitors have become game-changers in the treatment of estrogen receptor-positive (ER+) breast cancer, and in combination with endocrine therapy are the standard of care first-line treatment for ER+/HER2-negative advanced breast cancer. Although CDK4/6 inhibitors prolong survival for these patients, resistance is inevitable and there is currently no clear standard next-line treatment. There is an urgent unmet need to dissect the mechanisms which drive intrinsic and acquired resistance to CDK4/6 inhibitors and endocrine therapy to guide the subsequent therapeutic decisions. We will review the insights gained from preclinical studies and clinical cohorts into the diverse mechanisms of CDK4/6 inhibitor action and resistance, and highlight potential therapeutic strategies in the context of CDK4/6 inhibitor resistance.
Transforming growth factor-β signalling regulates protoscolex formation in the Echinococcus multilocularis metacestode
Authors: Kaethner Marc , Epping Kerstin , Bernthaler Peter , Rudolf Kilian , Thomann Irena , Leitschuh Nadine , Bergmann Monika , Spiliotis Markus , Koziol Uriel , Brehm Klaus
Published: March 2023

The lethal zoonosis alveolar echinococcosis (AE) is caused by tumor-like, infiltrative growth of the metacestode larval stage of the tapeworm Echinococcus multilocularis. We previously showed that the metacestode is composed of posteriorized tissue and that the production of the subsequent larval stage, the protoscolex, depends on re-establishment of anterior identities within the metacestode germinative layer. It is, however, unclear so far how protoscolex differentiation in Echinococcus is regulated. We herein characterized the full complement of E. multilocularis TGFβ/BMP receptors, which is composed of one type II and three type I receptor serine/threonine kinases. Functional analyzes showed that all Echinococcus TGFβ/BMP receptors are enzymatically active and respond to host derived TGFβ/BMP ligands for activating downstream Smad transcription factors. In situ hybridization experiments demonstrated that the Echinococcus TGFβ/BMP receptors are mainly expressed by nerve and muscle cells within the germinative layer and in developing brood capsules. Interestingly, the production of brood capsules, which later give rise to protoscoleces, was strongly suppressed in the presence of inhibitors directed against TGFβ/BMP receptors, whereas protoscolex differentiation was accelerated in response to host BMP2 and TGFβ. Apart from being responsive to host TGFβ/BMP ligands, protoscolex production also correlated with the expression of a parasite-derived TGFβ-like ligand, EmACT, which is expressed in early brood capsules and which is strongly expressed in anterior domains during protoscolex development. Taken together, these data indicate an important role of TGFβ/BMP signalling in Echinococcus anterior pole formation and protoscolex development. Since TGFβ is accumulating around metacestode lesions at later stages of the infection, the host immune response could thus serve as a signal by which the parasite senses the time point at which protoscoleces must be produced. Overall, our data shed new light on molecular mechanisms of host-parasite interaction during AE and are relevant for the development of novel treatment strategies.
Treatment of severe tricuspid regurgitation induced by permanent pacemaker lead: Transcatheter tricuspid valve replacement with the guidance of 3-dimensional printing
Authors: Mao Yu , Liu Yang , Meng Xin , Ma Yanyan , Li Lanlan , Zhai Mengen , Jin Ping , Lu Fanglin , Yang Jian
Published: March 2023

Background

Lead-induced tricuspid regurgitation is one of the complications after permanent pacemaker implantation (PPI) and refers to tricuspid regurgitation (TR) caused by the lead in the right ventricle (RV).

Objectives

To study the clinical characteristics of severe TR after PPI and the effect of transcatheter tricuspid valve replacement (TTVR) with the guidance of 3-dimensional (3D) printing.

Methods

This study was a single-center, descriptive study. Six patients with severe TR after PPI were enrolled in Xijing Hospital from January 2020 to May 2020. Before TTVR, the 3D printed tricuspid valve (TV) model was used for evaluation in the bench test. LuX-Valve was implanted under the guidance of TEE and x-ray fluoroscopy, and all patients underwent transatrial access. Six patients’ data were collected at baseline, before discharge, and 6 months, 1 year and 2 years after TTVR.

Results

The LuX-Valve was successfully implanted in 6 patients, TR was significantly reduced to ≤2+, and no deaths or cardiopulmonary bypass occurred during procedures. Three cases were caused by TV expansion: Patient #4 had TR caused by lead adhesion to TV, Patient #2 had TR caused by lead winding, and Patient #6 had TR caused by lead impingement on TV. During the 2-year follow-up, TTE revealed that 5 patients had no/trace regurgitation, and one patient (Patient #5) had mild regurgitation. All 6 patients (100.0%) reached primary endpoints.

Conclusion

TTVR guided by 3D printing is safe and effective in the treatment of severe TR associated with permanent pacemaker lead, providing prospects and possibilities for the precise treatment of TV-related diseases.

Clinical Trial Registration: ClinicalTrials.gov Protocol Registration System (NCT02917980).
Critical area identification and dynamic process simulation for landslide hazard chain formation in the upstream Jinsha River
Authors: Song Yixian , Deng Hongyan , Tang Chenxiao , Li Bokai
Published: March 2023

The upper reaches of the Jinsha River, with their complex terrain and active tectonic movements, are vulnerable to landslide-induced hazard chain events, which endanger the safety of residents and infrastructure construction. Based on the analysis of the development background of the hazard chain in the upstream area of the Jinsha River, five factors, including the lithology, distance to faults, distance to rivers, peak ground acceleration, and slope degree, were selected to identify the critical landslide-prone areas. Principal component and grey correlation analyses were then conducted to determine the contributions of these different factors. Based on ArcGIS, the study zone was categorized into five classes of landslide susceptibility: very high, high, moderate, low, and very low. The identification of the critical target areas for landslide hazard chain formation showed satisfactory accuracy. The very high- and high-susceptibility areas are concentrated along the Jinsha River. The dynamic process of a typical landslide in a very high-susceptibility area was numerically simulated using OpenLISEM. The high-precision Baige landslide data of the study area were used to calibrate the practicality of the input mass parameters, including cohesion, internal friction angle, D50, and D90. The movement and accumulation processes of a typical landslide were then numerically simulated with the verified data. The entire landslide accumulation covers an area of 0.45 km2, with a length of 1,600 m and a width of 270 m. Thus, the OpenLISEM model, which combines mass, topography, and landcover parameters, is feasible for the numerical simulation of landslide dynamic processes. The prediction of the dynamic processes and accumulation morphology of landslides can provide a reference for the formation processes and mechanisms of the landslide-induced hazard chain in the upper Jinsha River.
Altered ureido protein modification profiles in seminal plasma extracellular vesicles of non-normozoospermic men
Authors: Roy Rosa , Lorca Cristina , Mulet María , Sánchez Milán José Antonio , Baratas Alejandro , de la Casa Moisés , Espinet Carme , Serra Aida , Gallart-Palau Xavier
Published: March 2023

Introduction

Extracellular vesicles (EVs) have been recognized as key players in numerous physiological functions. These vesicles alter their compositions attuned to the health and disease states of the organism. In men, significant changes in the proteomic composition(s) of seminal plasma EVs (sEVs) have already been found to be related to infertility.

Methods

Methods: In this study, we analyze the posttranslational configuration of sEV proteomes from normozoospermic (NZ) men and non-normozoospermic (non-NZ) men diagnosed with teratozoospermia and/or asthenozoospermia by unbiased, discovery-driven proteomics and advanced bioinformatics, specifically focusing on citrulline (Cit) and homocitrulline (hCit) posttranscriptional residues, both considered product of ureido protein modifications.

Results and discussion

Significant increase in the proteome-wide cumulative presence of hCit together with downregulation of Cit in specific proteins related to decisive molecular functions have been encountered in sEVs of non-NZ subjects. These findings identify novel culprits with a higher chance of affecting fundamental aspects of sperm functional quality and define potential specific diagnostic and prognostic non-invasive markers for male infertility.