bluuebunny/crossref_metadata_2025 huggingface dataset:
LDH-GO composites as catalysts for the oxidative removal of indigo carmine
dye from wastewater
Authors: Stamate Alexandra Elisabeta , Zavoianu Rodica , Pavel Octavian Dumitru , Cruceanu Anca , Corobea Mihai Cosmin , Osiac Mariana , Cioatera Nicoleta
Published: October 2020

Herein, we present the results of our researches focused on obtaining composites with enhanced affinity for indigo carmine (IC) by combining two different 2D materials e.g. graphene oxide (GO) and a Cerium modified layered double hydroxide (LDH), which could act as catalysts for the oxidative removal of IC, both under ultrasonic irradiation and under conventional stirring, using H2O2 as oxidation agent. Three Mg3Al0.75Ce0.25 LDH-GO composites bearing different concentrations of GO in the range of 5-15 wt.% abbreviated as HT3Ce-xGO where x stands for the concentration of GO (x=5,10,15% wt. GO) have been prepared and characterized by XRD, SEM, Raman and DRIFT spectroscopy. The XRD patterns of HT3Ce-xGO solids have revealed the formation of nanocomposites with fine particles of CeO2 (Scherrer dimensions around 3 nm) embedded in the 2D layered structure of LDH-GO. CeO2 phase was favored by the increase in GO content for all investigated composites. The size decrease of the solid particles with the increase of GO content was proved both by SEM and DRIFT analyses. Raman spectra proved the incorporation of GO in all composites. The results of the catalytic tests showed, without any doubt the activation effect of the ultrasonic irradiation which allowed doubling the dye removal percentage (DR%) in the first 30 minutes of reaction time. For the most active catalyst, HT3Ce-15GO, the COD after 30 minutes reaction time under ultrasonic irradiation was 221 mgO2/L, while TOC was 93 mgC/L marking a decay of 61.6% for COD and 46.2% for TOC.
Application of ultrasonic disintegration to waste activated sludge for increasing
of biogas production by anaerobic digestion
Authors: Patroescu Ion Viorel , Dinu Razvan Laurentiu , Stefanescu Mihai , Badescu Valeriu Robert , Cristea Nicolae Ionut , Martin Coline
Published: October 2020

The municipal wastewater treatment is the source of significant amounts of primary and secondary sludge which is under the present legislation referring to quality and management aspects. It is estimated that a half of wastewater treatment plant costs are due to the sludge management. Anaerobically sludge stabilization, capitalization as energy source, in order to diminish the costs and sludge volume decreasing, are the aims of the main operational steps of sludge treatment, as a part of wastewater treatment plant. The improvement of sludge anaerobically stabilization process must be possible by acting in the rate limiting step - hydrolysis in order to rise the organic carbon solubilization. The increase of soluble carbon can be possible by adding a pretreatment step of waste biological sludge, ultrasonic disintegration being one option. This paper emphasized the experimental results regarding anaerobically stabilization of the thickened waste biological sludge by ultrasonication taking into account the results of blank test, without ultrasonication. Experimental tests show that ultrasonic disintegration of the sludge having initial dried substances content (d.w) 2.72% and soluble organic load COD of 598 mg O2/L led to soluble COD concentration of 4950-6710 mg O2/L after sonication with specific energy in the range of 3.06 - 14.24 kWh/kg d.w. Anaerobically stabilization during 25 test days at 36 0C of the mixture 40% disintegrated biological sludge and 60% digested sludge (inoculum) mixture led to 30-38.6% increase of biogas production comparing with parallel test with non-sonicated sludge.
DNA Methylation Markers in Lung Cancer
Authors: Hong Yoonki , Kim Woo Jin
Published: October 2020

Lung cancer is the most common cancer and the leading cause of cancer-related morbidity
and mortality worldwide. As early symptoms of lung cancer are minimal and non-specific, many patients
are diagnosed at an advanced stage. Despite a concerted effort to diagnose lung cancer early, no
biomarkers that can be used for lung cancer screening and prognosis prediction have been established
so far. As global DNA demethylation and gene-specific promoter DNA methylation are present in lung
cancer, DNA methylation biomarkers have become a major area of research as potential alternative diagnostic
methods to detect lung cancer at an early stage. This review summarizes the emerging DNA
methylation changes in lung cancer tumorigenesis, focusing on biomarkers for early detection and
their potential clinical applications in lung cancer.
Progress on the Mechanism for Aspirin’s Anti-tumor Effects
Authors: Zheng Lin , Lv Weibiao , Zhou Yuanqing , Lin Xu , Yao Jie
Published: October 2020

Since its discovery more than 100 years ago, aspirin has been widely used for its antipyretic, analgesic, anti-inflammatory, and anti-rheumatic activities. In addition to these applications, it is increasingly becoming clear that the drug also has great potential in the field of cancer. Here, we briefly review current insights of aspirin’s anti-tumor effects. These are multiple and vary from inhibiting the major cellular mTOR pathways, acting as a calorie-restricted mimetic by inhibition of energy production, suppressing platelet aggregation and granule release, inhibiting immune escape of tumor cells, to decreasing inflammatory responses. We consider these five mechanisms of action the most significant of aspirin’s anti-tumor effects, whereby the anti-tumor effect may ultimately stem from its inhibition of energy metabolism, platelet function, and inflammatory response. As such, aspirin can play an important role to reduce the occurrence, proliferation, and metastasis of various types of tumors. However, most of the collected data are still based on epidemiological investi-gations. More direct and effective evidence is needed, and the side effects of aspirin intake need to be solved before this drug can be widely applied in cancer treatment.
Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease
Authors: Singla Rajeev K. , Agarwal Tanya , He Xuefei , Shen Bairong
Published: October 2020

Parkinson’s disease is one of the most common adult-onset, a chronic disorder involving
neurodegeneration, which progressively leads to deprivation of dopaminergic neurons in substantia
nigra, causing a subsequent reduction of dopamine levels in the striatum resulting in tremor, myotonia,
and dyskinesia. Genetics and environmental factors are believed to be responsible for the onset
of Parkinson’s disease. The exact pathogenesis of Parkinson's disease is quite complicated and the
present anti-Parkinson's disease treatments appear to be clinically insufficient. Comprehensive researches
have demonstrated the use of natural products such as ginseng, curcumin, ashwagandha,
baicalein, etc. for the symptomatic treatment of this disease. The neuroprotective effects exhibited
by these natural products are mainly due to their ability to increase dopamine levels in the striatum,
manage oxidative stress, mitochondrial dysfunction, glutathione levels, clear the aggregation of α-
synuclein, induce autophagy and decrease the pro-inflammatory cytokines and lipid peroxidation.
This paper reviews various natural product studies conducted by scientists to establish the role of
natural products (both metabolite extracts as well as pure metabolites) as adjunctive neuroprotective
agents.
Risk Factors Associated with Acute Appendicitis in Pregnancy
Authors: Ahmadinejad Mojtaba , Hashemi Seyed Mozaffar , Jamee Mahnaz
Published: October 2020

Backgrounds::

Acute appendicitis has been considered as the most common non-obstetric
indication that requires surgical intervention in pregnant women.

Objective:

The aim of this study is to compare clinical manifestations and para-clinical indices
between pregnant and non-pregnant patients who have undergone appendectomy.

Methods::

In this prospective cohort study, 57 pregnant and non-pregnant women presenting appendicitis
were compared in terms of diagnostic indicators, histopathological characteristics and laboratory
findings.

Results::

Periumbilical region was the point of initiation of the pain; however, it was more prominent
in non-pregnant women. Similarly, tenderness in RLQ (right lower quadrant) of the abdomen
was more detectable in the non-pregnant group, and some of the cases showed no rebound tenderness.
Pregnant women with appendicitis presented an abnormal increase in the WBC count.

Conclusion::

Pregnancy and appendicitis-related signs and symptoms have similarity among them.
Due to pregnancy, the physical examination might not present an exact diagnosis; therefore, pregnant
women susceptible to have appendicitis must undergo a complete and careful on-time examination
that includes ultrasound and labs.
Discovery and Design of Peptides as MMP9 Inhibitors through Structure-Based Molecular Docking for Targeted Mantle Cell Lymphoma Therapy
Authors: Yan Wei , Yang Ying , Yang Wei , Wei Minjie
Published: October 2020

Background:

Enhanced expression and activation of metalloproteinase-9 (MMP9) are associated with
Mantle Cell Lymphoma (MCL) progression, invasion and metastasis.

Objective:

To find a potential peptide inhibitor against MMP9, which, in turn, could inhibit MCL progression.

Methods:

We performed CCK8 assay, western blot, and transwell assays for RNAi activity. Molecular Operating
Environment (MOE) software was applied for structural optimization as MMP9 and peptides were docked. We
used gelatin zymography and confocal microscopy to confirm that the peptides can inhibit MMP9 activity. We
applied CCK8 and transwell assay to evaluate cell proliferation and metastasis, and flow cytometry to evaluate
cell cycle progression and apoptosis.

Results:

High MMP9 expression was observed in 49 of 88 samples (55.7%). Patients with high MMP9
expression were more likely to present with high stage (Stage 3-4, P=0.01), bone marrow invasion (P=0.033),
and high-level LDH (P=0.000). High MMP9 expression was associated with significantly shorter overall survival
(OS, HR=2.378, P=0.012) and progression-free survival (PFS, HR=2.068, P=0.03). Multivariate analysis
identified high MMP9 expression (P= 0.027), high-risk mantle cell lymphoma international prognostic index
(MIPI, HR=2.327, P=0.023), and no radiation therapy (P=0.035) as adverse prognostic factors. The silencing of
MMP9 in Jeko-1 cells by RNAi suppressed cells migration and invasion in vitro (P<0.05). According to the
docking results, peptide M3 bound deeply in the binding pocket of MMP9 and had interaction with the active-site
Zn2+ ion in the catalytic domain. M3 was not only compatible with MMP9, but also inhibited its activity. M3
inhibited Jeko-1 cells proliferation, metastasis, and cell cycle progression, and promoted cell apoptosis rate
(P<0.05).

Conclusion:

We designed M3 through structure-based molecular docking, which can specifically bind to MMP9
and inhibit the activity of MMP9. M3 could be a potential antagonist in the treatment of MCL with MMP9
overexpression.
Mental and Emotional Wellbeing During the COVID-19 Pandemic: The Unprecedented Malaysian Experience
Authors: Mahmud Zamalia , Rahim Rosli Abdul , Abidin Aida Wati Zainan , Abdullah Nik Nairan Nik
Published: October 2020

Background:

The Movement Control Order (MCO) due to COVID-19 has brought people’s
life to almost a standstill. How people across different ages and income groups are mentally and
physically adjusting to the unprecedented situation in Malaysia is yet to be documented. Hence, an
empirical study was conducted to capture this real-time situation during COVID-19 MCO.

Objective:

To describe the mental and emotional wellbeing of Malaysians and how they care for themselves
and their family during the COVID-19 pandemic and during MCO.

Methods:

A survey on 3,288 respondents was conducted towards the end of the first phase of MCO.
The questionnaire was administered through various online social media platforms using snowball and
convenience sampling.

Results:

About 90% of the respondents gave their priority to health needs and in providing food, shelter
and clothing for their family, while education is at the bottom of their priority list. The overall index
of mental wellbeing and emotional stability went beyond 57% up to 95%, indicating that people
are mentally and emotionally disturbed with COVID-19. The index ranges between 49% up until 90%
in the ability to care for themselves and family.

Conclusion:

Health needs were at the top of the priority list of the high income group and least in the
low income group. While for the low income group, the top most priority concerns their financial stability.
Education was given the least priority by all income groups. Their greatest fear is the infection
of COVID-19 that would harm their family’s health. They were also stressed with the COVID-19 pandemic
that could affect the Malaysian economy and thus worried about losing their sources of income
if this pandemic prolongs over an indefinite period.
Perfil de los cruceristas que visitan la habana a través de las agencias de viajes Cubanacán y Cubatur
Authors: Rodríguez González Maite , Chávez Tamayo Olivia , Hernández Ruíz Alma Delia
Published: October 2020

El Caribe se ha posicionado como la principal región turística en la actividad de cruceros. La Habana, en el destino Cuba, también se ha destacado en esta actividad, aunque, en los últimos años se ha apreciado una disminución en el número de cruceristas atendidos por las agencias Cubatur y Viajes Cubanacán, pues se carece de un perfil del crucerista, de ahí que el diseño de sus excursiones se basa principalmente en las experiencias anteriores, las disposiciones del Ministerio de Turismo y las oportunidades del destino. Se definió como objetivo elaborar el perfil de los cruceristas que visitan La Habana a través de la Agencia de viajes Cubatur y Cubanacán. Se aplicaron métodos teóricos como el histórico o tendencial y lógico; y métodos empíricos como la encuesta. Además, la metodología utilizada fue la propuesta por Perelló (2005) sobre investigación de mercados. Los resultados muestran las características fundamentales de los cruceristas, apreciándose que sus perfiles son bastantes similares, resaltando los recorridos de ciudad y atractivos como Tropicana y los autos clásicos; solamente difieren con respecto a la nacionalidad de los clientes.
Valoración económica de dos prácticas de desalinización: caso de estudio Villamar-Michoacán, México
Authors: Lastiri Hernández Marcos Alfonso , Ochoa Estrada Salvador , Álvarez Bernal Dioselina
Published: October 2020

El objetivo de este estudio fue evaluar el costo que presenta la fitodesalinización respecto a la aplicación del yeso agrícola para rehabilitar una parcela con problemas severos de salinidad, a partir de las prácticas agrícolas, los precios de mercado y la infraestructura que disponen los productores del municipio de Villamar-Michoacán, México, para llevar a cabo su labor agrícola. Se hicieron recorridos de campo a los diferentes ejidos que conforman el municipio y se aplicaron 317 cuestionarios semiestructurados para conocer los elementos que se encuentran vinculados con su labor productiva. Para determinar el costo de la fitodesalinización, se consideró la producción de la biomasa, el manejo agronómico y el valor de la biomasa generada. En el caso del yeso agrícola, se consideraron cuatro aspectos: la preparación previa del suelo, la nivelación del terreno, el manejo agronómico y los costos relacionados con la adquisición de la enmienda. Los resultados mostraron que el costo de la fitodesalinización fue 8.1% menor, en comparación con la aplicación del yeso agrícola, al presentar un valor de $ 4,730.29 dólares por hectárea. Lo que demuestra que es una práctica agrícola sostenible, orientada a mejorar la economía de los productores, principalmente, cuando se busca implementar a gran escala.
The value placed on roles and attributes of clinical educators: An international comparison of Indian, South African and Australian undergraduate physiotherapy students.
Authors: Milanese Steve , Gordon Susan , Swaminathan Narasimman
Published: October 2020

Aim and Background: Clinical Education opportunities for undergraduate Physiotherapy students are now increasingly occurring internationally. The clinical educator (CE) plays a significant role in the clinical education process particularly when a student undertakes a clinical placement in a different country as the CE often takes on a surrogate caretaker role. This study explores the self-reported perceptions of Physiotherapy students from three countries representing different global society clusters – South Africa (Sub-Saharan Africa), India (Southern Asia) and Australia (Anglo), regarding the roles and attributes of a CE that they value in the clinical education process.

Method: Data was collected from undergraduate Physiotherapy students in a university in India (n=23) and Australia (n=154) and compared with data from a similar student cohort in South Africa (n=70). Students were asked roles and attributes of a clinical educator were of most value in the clinical education setting.

Results: The relative values placed on CE roles/attributes across the three cohorts was similar, however specific differences between cohorts suggest that clinical educators should be aware of differences when supervising international students.
Machine Learning Prediction of Foodborne Disease Pathogens: Algorithm Development and Validation Study (Preprint)
Authors: Wang Hanxue , Cui Wenjuan , Guo Yunchang , Du Yi , Zhou Yuanchun
Published: October 2020

BACKGROUND

Foodborne diseases, as a type of disease with a high global incidence, place a heavy burden on public health and social economy. Foodborne pathogens, as the main factor of foodborne diseases, play an important role in the treatment and prevention of foodborne diseases; however, foodborne diseases caused by different pathogens lack specificity in clinical features, and there is a low proportion of clinically actual pathogen detection in real life.

OBJECTIVE

We aimed to analyze foodborne disease case data, select appropriate features based on analysis results, and use machine learning methods to classify foodborne disease pathogens to predict foodborne disease pathogens that have not been tested.

METHODS

We extracted features such as space, time, and exposed food from foodborne disease case data and analyzed the relationship between these features and the foodborne disease pathogens using a variety of machine learning methods to classify foodborne disease pathogens. We compared the results of 4 models to obtain the pathogen prediction model with the highest accuracy.

RESULTS

The gradient boost decision tree model obtained the highest accuracy, with accuracy approaching 69% in identifying 4 pathogens including Salmonella, Norovirus, Escherichia coli, and Vibrio parahaemolyticus. By evaluating the importance of features such as time of illness, geographical longitude and latitude, and diarrhea frequency, we found that they play important roles in classifying the foodborne disease pathogens.

CONCLUSIONS

Data analysis can reflect the distribution of some features of foodborne diseases and the relationship among the features. The classification of pathogens based on the analysis results and machine learning methods can provide beneficial support for clinical auxiliary diagnosis and treatment of foodborne diseases.
Using an mHealth App (iGAM) to Reduce Gingivitis Remotely (Part 2): Prospective Observational Study (Preprint)
Authors: Tobias Guy , Spanier Assaf B
Published: October 2020

BACKGROUND

Gingivitis is a nonpainful, inflammatory condition that can be managed at home. Left untreated, gingivitis can lead to tooth loss. Periodic dental examinations are important for early diagnosis and treatment of gum diseases. To contain the spread of the coronavirus, governments, including in Israel, have restricted movements of their citizens which might have caused routine dental checkups to be postponed.

OBJECTIVE

This study aimed to examine the ability of a mobile health app, iGAM, to reduce gingivitis, and to determine the most effective interval between photograph submissions.

METHODS

A prospective observational cohort study with 160 unpaid participants divided into 2 equal groups using the iGAM app was performed. The intervention group photographed their gums weekly for 8 weeks. The wait-list control group photographed their gums at the time of recruitment and 8 weeks later. After photo submission, the participants received the same message “we recommended that you read the information in the app regarding oral hygiene habits.” A single-blinded researcher examined all the images and scored them according to the Modified Gingival Index (MGI).

RESULTS

The average age of the intervention group was 26.77 (SD 7.43) and 28.53 (SD 10.44) for the wait-list control group. Most participants were male (intervention group: 56/75,74.7%; wait-list control group: 34/51, 66.7%) and described themselves as “secular”; most were “single” non-smokers (intervention group: 56/75, 74.7%; wait-list control group: 40/51, 78.4%), and did not take medications (intervention group: 64/75, 85.3%; wait-list control group: 40/51, 78.4%). A total of 126 subjects completed the study. A statistically significant difference (P<.001) was found in the dependent variable (MGI). Improvements in gingival health were noted over time, and the average gingivitis scores were significantly lower in the intervention group (mean 1.16, SD 1.18) than in the wait-list control group (mean 2.16, SD 1.49) after 8 weeks. Those with more recent dental visits had a lower MGI (P=.04). No association was found between knowledge and behavior. Most participants were familiar with the recommendations for maintaining oral health, yet they only performed some of them.

CONCLUSIONS

A dental selfie taken once a week using an mobile health app (iGAM) reduced the signs of gingivitis and promoted oral health. Selfies taken less frequently yielded poorer results. During the current pandemic, where social distancing recommendations may be causing people to avoid dental clinics, this app can remotely promote gum health.
Records of lichen species new for Ukraine from steppe habitats of the country
Authors: Khodosovtsev Alexander , Darmostuk Valery
Published: October 2020

The lichens Arthonia cretacea, Bacidia viridescens, Candelariella
blastidiata, C. xanthostigmoides, Enchylium bachmanianum, Haematomma
nemetzii, Lecania triseptata, Lecidea sarcogynoides, Ramalina europaea,
Sarcogyne praetermissa and Xanthocarpia diffusa are reported for the first
time from Ukraine. Xanthocarpia interfulgens is confirmed from an arid
Ukrainian landscape. Locations, herbarium deposits and substrates are given,
together with notes on worldwide distribution of the reported taxa and
morphological differences from similar species.
ALETHIC PLURALISM AND TRUTH-ATTRIBUTIONS
Authors: Wrenn Chase
Published: October 2020

The core of alethic pluralism is the idea that truth is a different property in some discourses from others. Orthodox pluralists such as Crispin Wright and Michael Lynch share three commitments that motivate their view. One is Ecumenicalism, the view that scientific and moral claims are both truth-apt. The second is Occasional Realism, the view that truth in science is a matter of justificationindependent, accurate representation, while truth in ethics is a matter of ideal epistemic justifiability. The third is Normativism, the view that truth-attributions are normative in a way deflationary theories cannot accommodate. This paper articulates the “aletheiological dilemma” for orthodox pluralists. The dilemma arises when we ask whether the truth-property relevant to truth-attributions is epistemic. Occasional Realism requires it not be, but Normativism and the pluralists’ other commitments require truth for truth-attributions to be a matter of ideal justifiability. The paper also considers some ways around the dilemma, none of which looks very promising for pluralists.
THE FORCE OF ALETHIC PLURALISM
Authors: Strollo Andrea
Published: October 2020

Belief, according to many philosophers, aims at truth. In this paper I discuss in what measure a pluralist conception of truth is compatible with this claim. In particular, I argue that if the idea is understood according to a teleological account, alethic pluralism can be adopted also in a strong form. I contend that while the teleological account of belief requires a generic concept of truth, it poses a few constraints on the property (or the properties) of truth. By contrast, at least a moderate version of alethic pluralism is commanded by a normativist interpretation of the aim.
Political Patronage, Audit Quality, and the Properties of Analysts' Earnings Forecasts in Malaysia
Authors: Gist Willie E. , Abdul Wahab Effiezal Aswadi
Published: October 2020

Based on a sample of 2,034 Malaysian listed firm-year observations for the period 2007–2014, this study shows a negative relationship between dimensions of political patronage (i.e., politically connected firms and the percentage of Bumiputera directors) and analysts' earnings forecast accuracy. Furthermore, the study documents a positive relationship between Bumiputera directors and earnings forecast dispersion. These results suggest that the political patronage of firms is associated with low-quality earnings. We also find that measures of high audit quality are associated with high financial reporting quality and that this is evident in firms with high audit quality showing a weaker negative (positive) relationship between forecast accuracy (dispersion) and political connections and high levels of Bumiputera directors. Overall, the findings suggest that high audit quality plays an important role in mitigating agency costs of information asymmetry by improving the financial information environment.

JEL Classifications: G24; G34; G38.
Immune Checkpoint Inhibitor–Associated Diabetes: A Single-Institution Experience
Authors: Byun David J. , Braunstein Rebecca , Flynn Jessica , Zheng Junting , Lefkowitz Robert A. , Kanbour Sarah , Girotra Monica
Published: October 2020

OBJECTIVE

To characterize immune checkpoint inhibitor–associated diabetes mellitus (ICI-DM) in a single-institution case series.

RESEARCH DESIGN AND METHODS

Retrospective chart review of 18 patients with new-onset ICI-DM following anti–programmed cell death protein 1 (PD-1)/anti–programmed cell death protein ligand 1 (PD-L1) therapy for advanced carcinomas.

RESULTS

Of 18 patients, 9 had diabetic ketoacidosis (median glucose 27.92 mmol/L; median glucose before presentation 6.35 mmol/L). Median C-peptide at ICI-DM diagnosis was low, and it declined during follow-up. Median anti-PD-1/anti-PD-L1 duration before ICI-DM was 3.65 months (range 0.56–12.23 months). Time to ICI-DM onset was a median 1.4 months/3 ICI cycles and 6 months/10 cycles in those patients who were positive and negative for GAD65 autoantibodies, respectively. Time to ICI-DM onset was a median 2.5 months/3 ICI cycles and 4.8 months/8 cycles after anti-PD-L1 or anti-PD-1 therapy, respectively. Significant pancreatic atrophy was seen radiographically.

CONCLUSIONS

ICI-DM presents abruptly, appears irreversible, is characterized by pancreatic atrophy, and may occur both earlier following PD-L1 blockade compared with PD-1 inhibition and in those who have positive GAD65 autoantibodies.
Implementación de un sistema de monitoreo IoT aplicado a una piscicultura de trucha
Authors: Piamba-Mamian Tito Manuel , Zambrano Leidy Estefanía , Montaño Rúales Luis Alexander , Rojas Gonzales Francisco Arturo
Published: October 2020

La creciente producción de trucha arcoíris en Colombia requiere el aumento de sus procesos productivos. Por ello, se debe incrementar la obtención de ovas y alevinos en las pisciculturas para satisfacer así la demanda del producto final. El mercado actual se divide en la producción de carne y la venta de alevinos, de ahí, la necesidad de implementar un sistema de monitoreo en la etapa inicial de la producción (alevinos), debido a que esta involucra un alto grado de mortalidad ocasionada por su delicadeza y a factores que son desconocidos por el piscicultor, como el valor de pH, temperatura y oxígeno disuelto, entre otros, originando pérdidas económicas y hasta el cierre de sus negocios. Cuando se identifican procesos relacionados con tecnologías e Industria 4.0 “cuarta revolución industrial”, poniendo en marcha componentes de hardware y software, con el fin de fortalecer procesos productivos enfocados a mejorar las necesidades de usuarios, al hablar de tecnologías se generan ideas innovadoras concernientes a grandes fábricas y, por ende, elevados costosos en proyectos. Sin embargo, a partir de la transformación digital se han plasmado escenarios en donde se da lugar a modestos propósitos, que aportan un alto retorno de la inversión en vía de optimización de la producción. Por lo anterior, la presente investigación tiene como objetivo principal establecer un modelo de sistema constructivo orientado en la utilización de técnicas Internet of Things (IoT), identificando variables en tiempo real como temperatura, oxígeno disuelto, pH que permitan disminuir la mortalidad de la trucha arcoíris en etapas tempranas (ovas, larvas y alevinos), beneficiando así a pequeños productores y satisfaciendo la demanda nacional e internacional.
LOGÍSTICA EM EVENTO: ESTUDO DE CASO DE UMA COMISSÃO DE FORMATURA LOCALIZADA NO INTERIOR DO SUL DE MINAS GERAIS
Authors: Ferreira Leticia Silva , Andrade Daniela Meirelles , Vieira Luciana Dos Santos , Gonçalves Vinicius Batista
Published: October 2020

Esta pesquisa tem como objetivo identificar e descrever as atividades logísticas necessárias para a realização do mesmo. Além disso, pretende detectar as possíveis falhas e propor melhorias para que o nível de serviço prestado não seja comprometido. A organização do baile envolve quatro fases, quais sejam: concepção – levantamento de informações; pré-evento – planejamento e organização; transevento – execução; pós-evento – desmontagem e avaliação. Em termos metodológicos, trata-se de um estudo de caso de abordagem quantitativo e qualitativo. Para a coleta dos dados, foram realizadas entrevistas semiestruturadas, observação participante e aplicação de questionário de avaliação pós-evento com a finalidade de obter a percepção e satisfação do cliente.  Na fase do pré-evento, existe um envolvimento maior dos organizadores em todo o planejamento do evento. Na execução do evento, é feita a conferência das atividades por meio do instrumento de controle checklist. Já no pós-evento, além da descrição das atividades de desmontagem, foi feita a avaliação por meio do questionário de satisfação do cliente. Conclui-se que o nível de serviço foi alcançado, mas existem algumas falhas a serem sanadas para os futuros eventos.
CONSTRUCTING A COURSE ON INDONESIAN SHADOW PUPPETS FOR INTERNATIONAL STUDENTS
Authors: Slamet Yosep Bambang Margono
Published: October 2020

Abstract: This paper is a course design on Indonesian shadow puppet to promote Indonesian culture to international students as a way of building a cultural bridge to create global citizens. In todays world, it is of paramount importance for every individual from diverse cultural, linguistic, and ethnic backgrounds to understand each other and work together. Creating this course is to introduce and promote an aspect Indonesian culture so that international students are more interested in and knowledgeable of Indonesian people and culture in general. Even though students only learn an aspect of Indonesian culture it is expected that they will be able to explore Indonesian culture in a broad sense.
TEACHER QUESTIONING IN CLASSROOM INTERACTION
Authors: Matra Sarlita Dewi
Published: October 2020

Questions play an important role in every classroomboth

students questions and teachers questions. The types of

question used by teacher can help students to lift their own

levels of understanding toward the concept given or even to

build up new ideas. The study explored (1) how eventually

teachers provide some ease to the students in creating an

interactive classroom interaction through questions and

answers exchanges; (2) how the questioning technique used by

the teachers might encourage the students to be active in

classroom interaction. By using Browns Interaction Analysis

System (BIAS) the data were analyzed in order to find out what

types of question were mostly used by the teachers during

teaching learning process in encouraging the students

activeness. The data were collected through observations in two

English classes in SMP N 2 Pekalongan with two different

English teachers. The data showed that the cognitive level of

teachers questions which mostly occurred was lower order

cognitive questions. The questions were aimed to invite the

learners to speak and deliver their ideas. Based on the observed

data, in details, the result showed that teachers used recall

questions for 52%, comprehension for 42% and application

occupied the remaining that was 6%. The target language was

usually used on several occasions such as praising, encouraging,

explaining and giving directions during the classroom

interaction. Therefore, the suggestions are given to the teacher

to understand practical uses of questioning techniques in

minimizingstudents barriers to speak up in English.
MEMORIZADORÍCONOSMAPAVERDE;juego de memoria para dispositivos móviles con Android sobre la metodología de Mapa Verde
Authors: Medina Carbó Yosvany , Rodríguez García Reina María , González Saily Leo
Published: October 2020

Para muchas personas cuando se habla de tecnologías y medio ambiente, se imaginan gran cantidad de equipos, técnicas, tecnologías, herramientas y aparatos contaminando mediante su desintegración y su mala gestión el entorno natural. Los juegos tecnológicos, aplicaciones, etc., utilizados de forma responsable, son un buen recurso educativo tanto para los niños, como para jóvenes y adultos. Se pueden encontrar diversos videojuegos como juegos tradicionales que tienen como objetivo divertir a la vez que sensibilizar por algún aspecto ambiental. Para ello en el presente trabajo se pretende desarrollar una app para dispositivos móviles que consiste en un juego de memoria con los íconos de la metodología definiéndose como problema a resolver: ¿cómo contribuir en la construcción de una aplicación informática consistente en un juego de memoria con los íconos de la metodología Mapa Verde para la implementación de la metodología de Mapa Verde en la gestión ambiental en comunidades consolareñas? Para dar solución al problema planteado se trazó como objetivo general: desarrollar un juego de memoria para la implementación de la metodología de Mapa Verde en la gestión de la educación ambiental en comunidades consolareñas que permita el conocimiento de los íconos de la metodología para el desarrollo de los mapas verdes.
Features of relapses and refractory forms of T-lymphoblastic lymphoma in children
Authors: Abashidze Z. A. , Dyakonova U. U. , Myakova N. V.
Published: October 2020

Lymphoblastic lymphoma (LBL) is a rapidly progressive, malignant disease from T and B progenitor cells. Lymphomas from T cell precursors (T-LBL) account for up to 80% of all LBLs. Despite the rather rare occurrence of T-LBL, the relapsing and refractory course of this disease is an actual problem. Programs for the treatment of relapses and refractory forms of T-LBL are currently being actively developing. The role and place of targeted drugs in the multimodal T-LBL relapse strategy is determined. Further fundamental research is aimed at overcoming drug resistance, studying the molecular genetic mechanisms, tumor cell signaling pathways, which will improve treatment outcomes and survival. Based on clinical case the authors will be considered clinical features of relapses and refractory form of T-LBL and possible methods of treatment. Parents gave their consent to use information about the child, including fotos, in the article.
Phenotypic and genetic properties of susceptible and multidrug-resistant Pseudomonas aeruginosa isolates in Southern Serbia
Authors: Milojković Marko , Nenadović Željka , Stanković Slaviša , Božić Dragana D. , Nedeljković Nataša Stanković , Ćirković Ivana , Petrović Marija , Dimkić Ivica
Published: October 2020

Drug resistance of Pseudomonas aeruginosa is a leading problem in hospital infections. The aim of this study was to determine the best molecular genetic discrimination method for Pseudomonas spp. isolates among 94 outpatients and inpatients and see their grouping by phenotype characteristics (biofilm formation, frequency of serotypes, pigmentation, production of different class of beta-lactamases, and susceptibility to different antibiotic classes) and genotype. The most common serotypes were P1, P6, and P11, while co-productions of pyoverdine and pyocyanin were observed in 70 % of isolates. A total of 77.66 % isolates were mostly weak and moderate biofilm producers. Isolates were susceptible to colistin (100 %), aztreonam (97.87 %), imipenem (91.49 %), doripenem (90.43 %), and meropenem (84.04 %). MICs values confirmed susceptibility to ceftazidime and cefepime and singled out meripenem as the most effective inhibitor. Most isolates were resistant to aminoglycosides and fluoroquinolones. Only two isolates produced ESBL, eight were carbapenemase producers, and five isolates produced MBLs. Twenty-nine isolates were multidrug-resistant; 82.8 % of which produced both pigments, 58.3 % were non-typeable, while the P6 and P11 serotypes were equally distributed (16.7 %). Thirteen MDR isolates were strong enzyme producers. RAPD PCR analysis using primer 272 proved the best at discriminatory fingerprinting for Pseudomonas isolates, as it allocated 12 clusters. A correlation between DNA patterns and antibiotic resistance, production of pigments, serotypes distribution, and biofilm formation was not observed, and only confirmed higher genetic heterogeneity among P. aeruginosa isolates, which suggests that other molecular methods are needed to reveal potential relations between genotypic patterns and phenotypic characteristics.
Oxidative stress under general intravenous and inhalation anaesthesia
Authors: Kundović Sandra Alavuk , Rašić Dubravka , Popović Ljiljana , Peraica Maja , Črnjar Ksenija
Published: October 2020

Oxidative stress occurs when reactive oxygen species (ROS) production overwhelms cell protection by antioxidants. This review is focused on general anaesthesia-induced oxidative stress because it increases the rate of complications and delays recovery after surgery. It is important to know what effects of anaesthetics to expect in terms of oxidative stress, particularly in surgical procedures with high ROS production, because their either additive or antagonistic effect may be pivotal for the outcome of surgery. In vitro and animal studies on this topic are numerous but show large variability. There are not many human studies and what we know has been learned from different surgical procedures measuring different endpoints in blood samples taken mostly before and after surgery. In these studies most intravenous anaesthetics have antioxidative properties, while volatile anaesthetics temporarily increase oxidative stress in longer surgical procedures.
Comparison of beautician and hairdressing apprentices with regard to skin health and skin barrier function
Authors: Babić Željka , Samardžić Tea , Macan Jelena
Published: October 2020

Hairdressing and beautician apprentices are at high risk of occupational skin diseases. Our objective was to compare the prevalence of skin symptoms and the condition of skin barrier between them at the end of vocational training. We recruited 101 hairdressing and 76 beautician apprentices (overall median age 17 years), who reported their history of skin symptoms through the Croatian translation of the Nordic Occupational Skin Questionnaire (NOSQ-2002) and had their hand skin clinically examined and evaluated with the Osnabrück Hand Eczema Severity Index (OHSI). Transepidermal water loss (TEWL) was measured following the standard procedure. Hairdressing apprentices reported significantly higher prevalence of hand/wrist eczema or urticaria than beautician apprentices (35 % vs 25 %, respectively; P=0.041) and higher severity of current hand eczema [median (range) 1.5 (0–8) vs 0.5 (0–4), respectively; P<0.001] and had higher hand TEWL values in those who washed their hands >20 times a day [median (interquartile range): 24.4 (19.7–33.7) vs 18.8 (15.4–23.2) g/ m2/h, respectively; P<0.001). Hairdressing apprentices had more severe clinical symptoms on the hands, and 83 % of those who reported eczema also reported that exacerbation occurred during practical training in comparison to 38 % of beautician apprentices. Our study is the first to report occupational hand and forearm skin issues in the beautician apprentices and also suggests that more effort is needed to improve training about safety at work, which should be specifically tailored for these two trades.
Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna
Authors: Över Sevgi Başalan , Güven Celal , Taskin Eylem , Sevgiler Yusuf
Published: October 2020

The aim of this study was to investigate the oxidative and apoptotic potential of fluoxetine, a widely used antidepressant in Turkey and the world, and of its metabolite norfluoxetine on a model non-target organism, Daphnia magna to see how exposure to this group of antidepressants (specific serotonin reuptake inhibitors) could affect the aquatic environment in which they end up. Juvenile D. magna specimens were chronically exposed to fluoxetine and norfluoxetine alone and in combination at concentrations found in the aquatic environment (0.091 and 0.011 μg/L, respectively) and to their 10-fold environmental concentrations for 21 days. Another group of 17-day-old animals were subacutely exposed to 100-fold environmental concentrations for four days. After exposure, we measured their glutathione peroxidase (GPx) and cholinesterase (ChE) activities, thiobarbituric acid-reactive substances (TBARS), and total protein content spectrophotometrically, while mitochondrial membrane potential (MMP) was analysed by fluorescence staining, and cytochrome c and ERK1/2 protein content by Western blotting. This is the first-time cytochrome c and ERK1/2 were determined at the protein level in D. magna. We also measured their carapace length, width, and caudal spine length microscopically. At environmental concentrations fluoxetine and norfluoxetine caused an increase in ChE activity and brood production. They also caused a decrease in juvenile carapace length, width, and caudal spine length and depolarised the mitochondrial membrane. At 10-fold environmental concentrations, GPx activity, lipid peroxidation levels, cytochrome c, and ERK1/2 protein levels rose. The most pronounced effect was observed in D. magna exposed to norfluoxetine. Norfluoxetine also decreased brood production. Similar effects were observed with subacute exposure to 100-fold environmental concentrations. However, total protein content decreased. All this confirms that fluoxetine and norfluoxetine have oxidative and apoptotic potential in D. magna. Daphnia spp. have a great potential to give us precious insight into the mechanisms of environmental toxicants, but there is still a long way to go before they are clarified in these organisms.
New Travelling Wave Solution-Based New Riccati Equation for Solving KdV and Modified KdV Equations
Authors: Rezazadeh Hadi , Korkmaz Alper , EL Achab Abdelfattah , Adel Waleed , Bekir Ahmet
Published: October 2020

A large family of explicit exact solutions to both Korteweg- de Vries and modified Korteweg- de Vries equations are determined by the implementation of the new extended direct algebraic method. The procedure starts by reducing both equations to related ODEs by compatible travelling wave transforms. The balance between the highest degree nonlinear and highest order derivative terms gives the degree of the finite series. Substitution of the assumed solution and some algebra results in a system of equations are found. The relation between the parameters is determined by solving this system. The solutions of travelling wave forms determined by the application of the approach are represented in explicit functions of some generalized trigonometric and hyperbolic functions and exponential function. Some more solutions with different characteristics are also found.
A Method of Directly Defining the inverse Mapping for a HIV infection of CD4+ T-cells model
Authors: Dewasurendra Mangalagama , Zhang Ying , Boyette Noah , Islam Ifte , Vajravelu Kuppalapalle
Published: October 2020

In 2015, Shijun Liao introduced a new method of directly defining the inverse mapping (MDDiM) to approximate analytically a nonlinear differential equation. This method, based on the Homotopy Analysis Method (HAM) was proposed to reduce the time it takes in solving a nonlinear equation. Very recently, Dewasurendra, Baxter and Vajravelu (Applied Mathematics and Computation 339 (2018) 758–767) extended the method to a system of two nonlinear differential equations. In this paper, we extend it further to obtain the solution to a system of three nonlinear differential equations describing the HIV infection of CD4+ T-cells. In addition, we analyzed the advantages of MDDiM over HAM, in obtaining the numerical results. From these results, we noticed that the infected CD4+ T-cell density increases with the number of virions N; but decreases with the blanket death rate μI
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MHD 3-dimensional nanofluid flow induced by a power-law stretching sheet with thermal radiation, heat and mass fluxes
Authors: Ghosh Sudipta , Mukhopadhyay Swati , Vajravelu Kuppalapalle
Published: October 2020

In this article, the three-dimensional Magnetohydrodynamics flow of a nanofluid over a horizontal non-linearly stretching sheet in bilateral directions under boundary layer approximation is addressed. A two-phase model has been used for the nanofluid. The influences of thermophoresis, Brownian motion and thermal radiation on heat and mass transfers are considered. Two different cases for the heat and mass transfers are studied. In the first case, uniform wall temperature and zero nanoparticles flux due to thermophoresis are considered. In the second case, prescribed heat and mass fluxes at the boundary are considered. By using the appropriate transformations, a system of non-linear partial differential equations along with the boundary conditions is transformed into coupled non-linear ordinary differential equations. Numerical solutions of the self-similar equations are obtained using a Runge–Kutta method with a shooting technique. Our results for special cases are compared with the available results in the literature, and the results are found to be in good agreement. It is observed that the pertaining parameters have significant effects on the characteristics of flow, heat and mass transfer. The results are presented and discussed in detail through illustrations.
Generalized Tetranacci Hybrid Numbers
Authors: Soykan Yüksel , Taşdemir Erkan
Published: October 2020

In this paper, we introduce the generalized Tetranacci hybrid numbers and, as special cases, Tetranacci and Tetranacci-Lucas hybrid numbers. Moreover, we present Binet’s formulas, generating functions, and the summation formulas for those hybrid numbers.