bluuebunny/crossref_metadata_2025 huggingface dataset:
Tingkat Pemahaman Variasi Latihan Fleksibility Pada Pelatih INKANAS DKI Jakarta
Authors: Mulia Lita , Ilham Muhamad , Herliana Kartika , Nugraha Bayu
Published: March 2024

ABSTRAK

Penelitian ini bertujuan untuk untuk mengetahui tingkat pemahaman variasi latihan kelentukan pada pelatih INKANAS DKI Jakarta, meningkatkan pemahaman variasi latihan fleksibility pada pelatih INKANAS DKI Jakarta sehingga dapat diterapkan dalam meningkatkan prestasi Karate INKANAS DKI Jakarta, membawa dampak perubahan kebijakan dalam pembuatan program latihan khususnya latihan fleksibility serta meningkatkan kualitas dan kuantitas menulis publikasi ilmiah bagi peneliti. Pengambilan data dilakukan pada 25 september 2022 di Jakarta dengan penyebaran kuisioner yang diisi oleh 77 responden. Responden dalam penelitian ini adalah para pelatih Karate INKANAS DKI Jakarta. Teknik analisis data dilakukan dengan menggunakan metode Guttman. tingkat pemahaman variasi latihan fleksibility pada pelatih Inkanas DKI Jakarta secara keseluruhan ialah tinggi. Diperoleh hasil tertinggi ialah pada Sub Bahasan Fleksibility sebesar 83.31%. Dan hasil terendah ialah pada Sub Bahasan Dynamic Streching yakni sebesar 19.48%. Dimana kondisi ini menunjukkan bahwa kemampuan yang ada sudah cukup baik untuk kemudian dijadikan landasan dalam pengembangan pembuatan dan pelaksanaan program latihan yang ditujukan untuk memaksimalkan potensi yang ada guna mencapai prestasi yang maksimal.

 

Kata kunci: Karate, Kelentukan, Guttman

 

ABSTRACT

This study aims to determine the level of understanding of flexibility training variations in INKANAS DKI Jakarta trainers, increase understanding of the variety of flexibility exercises in INKANAS DKI Jakarta trainers so that they can be applied in improving the achievements of INKANAS DKI Jakarta Karate, bringing the impact of policy changes in the creation of exercise programs, especially flexibility exercises and improving the quality and quantity of writing scientific publications for researchers. Data collection was carried out on September 25, 2022 in Jakarta with the distribution of questionnaires filled out by 77 respondents.The respondents in this study were INKANAS DKI Jakarta Karate trainers. The data analysis technique was carried out using the Guttman method.the level of understanding of the variation of flexibility training in the Inkanas DKI Jakarta trainer as a whole is high. The highest result was obtained in the Flexibility Sub-Discussion of 83.31%. And the lowest result was in the Dynamic Streching Sub-Discussion, which was 19.48%. Where this condition shows that the existing capabilities are good enough to then be used as a basis in the development of making and implementing exercise programs aimed at maximizing potential that exists in order to achieve maximum achievements.

 

Keywords: Karate, Fleksibility, Guttman
The Idea of Cross-Religious Dialogue in the Time of the Covid-19 Pandemic
Authors: Zainuri Ahmad , Amal M. Khusna
Published: March 2024

Interfaith dialogue is one of the keys to building harmony among religious believers. Religious intolerance and religious discrimination have spread throughout this country during the Covid-19 pandemic. Freedom of religion is still an issue that reaps violence in the end. Negative religious fanatics are not recommended in responding to diversity and existing realities. It is feared that it will have an impact on conflicts with religious nuances that have no completeness. The method used in this article is based on the theoretical concept of “interfaith dialogue”. So the result is that the idea of interfaith dialogue during the Covid-19 pandemic has become one of the important formulas in religious moderation. For example, interfaith dialogue in education, social, community and social media. It can be concluded that interfaith dialogue in these times of the Covid-19 pandemic is very necessary. Good for moral education, building religious and social diversity, and peaceful literacy with the aim of countering extremist narratives, discrimination, and intolerance on social media and in social life.
The Scripture and Javanese Tradition: the Meaning and Preserving of Gugur Gunung Tradition among Gunungpring’s People
Authors: Kholis Nor , Isnaini Subi Nur
Published: March 2024

This article examines the existence of a tradition and the content of the values of the Islamic scriptures (Al-Qur’an and Hadith) inherent and practiced in the Gugur Gunung tradition carried out by the community in Gunungpring Village, Magelang. Data were collected through in-depth interviews and analyzed qualitatively through Karl Mannheim’s sociological perspective of knowledge into three meanings: objective, expressive, and documentary. The results of the study are presented as follows. The objective meaning of the Gugur Gunung tradition is a tradition that has existed for a long time and is still being maintained today in various conditions. While expressive meaning can be captured two inherent meanings, namely the meaning of life in the later days and the meaning of the inheritance of past lives from ulama. The documentary meaning of this tradition is to foster harmonization (gotong royong, tolerance, please help) and as a medium of spirituality education for the community in maintaining a tradition. Through reading the Sociology of Knowledge using the three meanings above, it can be understood that the existence of a tradition that can survive in society will always continue to be preserved if two aspects are built that are bound together. First, internally there is a spiritual belief in  the values of the past and life in the later days. Secondly, externally, it deals with the order of socio-religious harmonization in society. The various values inherent in this tradition are in line with the teachings of the Islamic scriptures. Thus these values will continue to be produced and practiced in life in society.
Exploring Historical Traditions in Spatial Planning for Multi-Family Residential Buildings
Authors: Keldiyar Khudayberdiyev , Khosiyat Tashmatova
Published: March 2024

This study delves into the intricacies of spatial planning solutions for various types of residential and public buildings, highlighting a complex workflow in their design. Focusing on multi-family residential buildings, the research primarily considers economic factors during the design process. Specifically, it explores Uzbekistan's unique historical tradition in constructing residential buildings, offering insights into two distinct versions - national and European. Notably, these buildings predominantly feature separate courtyards. Through a comprehensive analysis of goals, methods, results, and implications, this study contributes valuable knowledge to the global discourse on architectural design and spatial planning.

Highlights:

The study explores the complexity of spatial planning solutions for residential and public buildings.

Economic considerations play a crucial role in the design of multi-family residential buildings.

Uzbekistan's historical tradition in residential construction reveals unique architectural features.

Keywords: Planning Solutions, Residential Buildings, Architectural Design
WITHDRAWN: Disparities in Somatic Comorbidities among Immigrants and Norwegians with and without Mental Disorders. A National Register Study
Authors: Hynek Kamila Angelika , Straiton Melanie , Abebe Dawit Shawel
Published: March 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Evaluation of a customized reactive nanoscale-zero-valent iron and zeolite thin capping blend for enhancing natural recovery of wetlands impacted by contaminated legacy gold mine tailings
Authors: Chapman Ellen Emily Vanessa , Campbell Linda M.
Published: March 2024

Legacy gold mine tailings from the 1800’s in Nova Scotia, Canada have elevated mercury (Hg) and arsenic (As) concentrations. Tailings, were slurried into wetlands without treatment. Over a century later, those impacted wetlands are still at risk and innovative in-situ treatment approaches to support natural biological and chemical recovery are needed. Here we report results of our proof-of-concept laboratory study with a customized reactive thin layer capping to limit mobility, bioaccumulation and toxicity of Hg and As in wetland sediment impacted by legacy tailings. The customized reactive amendment is a blend of NANOFER STAR nanoscale zero valent iron (nZVI) and fine-grained zeolite (clinoptilolite) inserted either below, or within a thin cap (silica sand, bentonite and zeolite) and placed over contaminated wetland sediments in beakers. Due to the high concentrations of Hg and As in sediments, invertebrates (Hyalella azteca, Daphnia magna and Caridina multidente) exposed to untreated wetland sediment exhibited high mortality and bioaccumulation of Hg. The reactive capping applications improved the survival of H. azteca and D. magna similar to the survival rates seen in our clean control sediment. Bioaccumulation of Hg was also reduced in C. multidente exposed to the treated sediment compared to the untreated sediment. Furthermore, total [Hg] and [As] in the overlaying water of treated contaminated sediments were reduced by 88% and 99% respectively. Our proof-of-concept testing of this reactive capping blend shows potential for managing and supporting natural recovery of wetlands impacted by historical gold-mine tailings.
A pilot clinical study to evaluate the accuracy of an autonomous dental implant robotic system in partially edentulism
Authors: Wang MiaoZhen , Liu Feng , Yu Tao , Zhan yalin , Ma Feifei , Rausch-Fan Xiaohui
Published: March 2024

Objectives
Robots have been increasingly being used for surgical procedures in different specialties. However, information about the accuracy of robot-assisted dental implant surgery is lacking. The purpose of this pilot clinical study was to investigate the accuracy of an autonomous dental implant robotic (ADIR) system in partially edentulous cases.
Material and methods
The ADIR system was used to place a total of 20 implants in 13 participants. Implant deviation from the planned positions was assessed to determine accuracy.The entry, apex, and angular deviations were described as means ± standard deviation. A 2-sample t test was used to compare implant deviation between the flap and flapless groups and between maxillary and mandibular implants (α = .05).
Results
The entry, apex, and angular deviations were 0.65 ± 0.32 mm, 0.66 ± 0.34 mm, and 1.52 ± 1.01 degrees, respectively, with no ststistically significant difference between the flap and flapless approaches (P > .05 ). No adverse events were encountered in any of the participants.
Conclusions
ADIR accuracy in this clinical series was comparable to that reported for static and dynamic computer-assisted implant surgery (CAIS). Robotic CAIS may be useful for dental implant placement, and may increase the quality and safety of the procedure.
Clinical relevance
The findings of this study shows that ADIR system might be a potential alternative for dental implant surgery.
Coal Sampe Preparation Strategy using the TENCAN GQM series Ball Milling device.
Authors: Gaesenngwe Gaesenngwe , RAGHUPATRUNI PRASAD , MAMVURA TIRIVAVIRI , Danha Gwiranai
Published: March 2024

The application of Semi Autogenous Grinding strategy in mineral beneficiation engineering is well defined and established unit operation that is qualified for liberation of valuable final products from various rock ores of various kinds. The TENCAN GQM series Ball Mill equipment was deployed throughout our investigation to learn on optimum setting factors that are crucial in achieving effective product quality outcome during coal beneficiation. Therefore, a Semi-autogenous grinding methodology was deployed for grinding five (5) different coal samples into a product stream ranging in particle size from below [−600μm, +38μm] through an optimized procedure that syndicate three(3) control parameters being the {A − powder filling (fc), B − ball loading (JB) and C − residence time or grinding duration (t)}. Moreover, to analyse the grinding kinetics during interaction to produce coal mass recovery at desirable particle size specification relevant for specific manufacturing industry. However, initially the coal sample material was acquired and characterized via three spectroscopy techniques {x – ray diffraction (XRD), x – ray fluorescence (XRF), scanning electron microscopy (SEM)}, to establish contrast of each sample material in composition, morphology, hardness, and the relative abundance of occurring species entrenched within the coal structure (inorganic matter). Hence using the Proximate testing, Ultimate testing, and petrography analysis the examination was possible for each sample type collected. The coal samples that were initially collected were assorted in particle sizes classification and were grouped as run-of-mine coals (−200mm), Cobbles (−75mm, +40mm), Nuts (−40mm, +25mm), Peas (−32mm, +14mm) and fines (−14mm) according to our laboratory sieve specifications. However, the acquired coal species were initially subjugated to a hardness testing using the Hardgrove grindability Index device that reported a variable coal grindability index value with material hardness increased from Nuts (60.37), Cobbles (64.58), ROM (66.84), Fines (66.99) to Peas (67.37) which are relatively soft compared to other coal samples. Process engineers, researchers and students in different organizations studying metallurgy and coal beneficiation etc., must be informed about factors affecting coal material preparation innovations and the health-safety risk encounter by the mineral engineer personal during handling and processing. Moreover, production efficacy is significantly improved through adopting optimized model functions that accurately increase the product recovery at lower power rating for the cumulative production path hence relevantly reducing the cost(s) of exacerbated by tedious and unnecessary methods.
Current indicators and metrics hinder effective urban climate adaptation
Authors: Olazabal Marta , Mansur Andressa V. , Sahay Samraj , Helmke-Long Laura , Bradaschia Massimiliano Granceri , Villaverde Ane , Garmendia Leire , Aboagye Prince Dacosta , Sharifi Ayyoob , Asamoah Obed , Mwangi Patricia , Lewis William , Izaola Borja , Feldman Ira
Published: March 2024

Assessing the effectiveness of climate adaptation action is the focus of intense debate across scientific and policy arenas. Measurement is essential for effective adaptation management and operation, and indicators and metrics (I&M) have a pivotal role. Surprisingly, there are very few systematic efforts to understand the advances in the provisioning of adaptation I&M. Here we analyse 137 publications and 901 I&M sourced in the scientific literature to measure adaptation to climate change, particularly, in urban areas where governments are increasingly placing efforts to prepare populations and infrastructures. A lack of common terminology, standardisation, and reference guidelines has resulted in a field that is complex to track and understand. Furthermore, such complexity has led to diverse, context-specific and sometimes competing approaches to developing I&M. We argue that current I&M proposals are highly technical, not sufficiently grounded on real needs, and have little potential to collectively support effective urban climate change adaptation.
Loss of function of MusaPUB genes in banana can provide enhanced resistance to bacterial wilt disease
Authors: Tripathi Leena , Ntui Valentine , Shah Trushar , Tripathi Jaindra
Published: March 2024

Plants deploy a sophisticated defense mechanism against pathogens through pattern recognition receptors (PRRs) and resistance (R) proteins, activating pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). E3 ubiquitin ligases, notably U-box types like PUB22 and PUB23, modulate PTI by suppressing immune responses. The role of MusaPUB22/23 in immunity against Xanthomonas campestris pv. musacearum (Xcm), the cause of banana Xanthomonas wilt (BXW) in East Africa, was investigated by knocking out these genes in the BXW-susceptible 'Sukali Ndiizi' cultivar. Confirmed edited events demonstrated enhanced resistance against Xcm without compromising growth. Suppressed MusaPUB22/23 expression upon Xcm infection in the pub22/23 events underscored their negative immune regulation role. The enhanced expression of defense-related genes in edited events indicates improved immunity. This study showcases MusaPUB22/23 knockout as a promising strategy against BXW, addressing a crucial agricultural issue in East Africa while unraveling plant immunity regulation and paving the way for disease-resistant crop engineering targeting PUB genes.
Exploring Broccoli's Secondary Metabolites as Promising Inhibitors against Monkeypox: In silico Approach
Authors: Gangwar Upanshu , . Pooja , Deep Shashank
Published: March 2024

Monkeypox (Mpox) is a complex health condition driven by the elusive monkeypox virus (MPXV). This double-stranded DNA virus thrives exclusively within the cytoplasm of infected cells. Presently, a specific remedy for Mpox remains elusive. However, there is a glimmer of hope in the form of Tecovirimat – an FDA-approved drug renowned for its effectiveness against smallpox. Intriguingly, Tecovirimat has gained approval based on studies involving nonhuman primates infected with the MPXV. This exploration focuses on Broccoli (Brassica oleracea var. Italica). Revered across generations for its potential to address skin ailments, enhance the immune system, and promote cardiovascular health, Broccoli takes center stage in our investigation. This article delves into a novel dimension as we computationally scrutinize the bioactive metabolites within broccoli, probing their potential inhibitory properties against MPVX. Utilizing virtual screening, molecular dynamics, and the MMPBSA approach, we assessed the inhibitory properties of 47 bioactive metabolites from broccoli against MPXV. Comparisons were drawn with Tecovirimat. SwissADME and AutoDock Vina tools facilitated virtual screening, while GROMACS 2018, employing amber99sb-ildn forcefield, conducted molecular dynamics simulations. Parameters such as RMSD, RMSF, SASA, Rg, and hydrogen bonding were analyzed to evaluate MPXV-ligand complex stability. Binding energies were determined through MMPBSA calculations.
Impact of Security assessment for more secure software – A Tactics and Multi-Dimensional Perspective
Authors: Ali Mohammad , Uddin Md Sala , Uddin Nayeem , Hasan MD Mahbub
Published: March 2024

Security assessments are one of the most impactful points for developing more secure software that provides identification of security vulnerabilities, finding risks, and threats effective and strongest defense against them. The quality of the security system can be possible maximized through the prioritization of every aspect of the software system and the execution of a thorough standard security assessment. In this paper, we proposed a secure flow of software security requirements, Security pattern framework, and Threat and Risk assessment. The framework provides a secure flow of software security systems to detect attack patterns, block, response, and recovery through a systematic analysis. We implement prioritization and specification of security aspects in consideration of security requirements. Tactics and multidimensional perspective to provide appropriate solutions by unifying all components of the security function and all related issues. Security goals aim to mitigate risks and protect from threats, which is done through an appropriate risk and threat assessment model. In addition, we show an integrated threat model which specifies security and mitigates threat and risk. The results of this study will help the software development cycle to develop more secure software and increase the effectiveness of the software security system.
Increase of secondary metabolites in sweet basil (Ocimum basilicum L.) leaves by exposure to N2O5 with plasma technology
Authors: TATEISHI Rie , OGAWA-KISHIDA Natsumi , FUJII Nobuharu , NAGATA Yuji , OHTSUBO Yoshiyuki , SASAKI Shota , TAKASHIMA Keisuke , KANEKO Toshiro , HIGASHITANI Atsushi
Published: March 2024

Exposure to N2O5 generated by plasma technology activates immunity in Arabidopsis through tryptophan metabolites. However, little is known about the effects of N2O5 exposure on other plant species. Sweet basil synthesizes many valuable secondary metabolites in its leaves. We therefore performed metabolomic analyses at three different levels exposure levels to assess the effects of N2O5 on basil leaves. The results showed that cinnamaldehyde increased in a dose-dependent manner, accompanied by transcriptional activation of the cinnamoyl-CoA reductase CCR2 gene. Phenolic acids also increased with increasing doses. Certain flavonoids, columbianetin, and caryophyllene oxide increased with lower Ex1 exposure, cineole and methyl eugenol increased with moderate Ex2 exposure and L-glutathione GSH also increased with higher Ex3 exposure. Furthermore, N2O5 altered jasmonic acid signaling in a dose-dependent manner. These results suggest that N2O5 exposure increases several valuable secondary metabolites in sweet basil leaves via plant defense responses in a controllable system.
Fundamental Insights and Recent Advances in Catalytic Oxidation Processes Using Ozone for the Control of Volatile Organic Compounds
Authors: Einaga Hisahiro , Zheng Xuerui
Published: March 2024

The development of technologies for highly efficient treatment of emissions containing low concentrations of volatile organic compounds (VOCs) remains an important challenge. Catalytic oxidation with ozone (catalytic ozonation) is useful for the oxidative decomposition of VOCs, particularly aromatic compounds, under ambient temperature conditions. Only inexpensive transition metal oxides are required as catalysts, and Mn-based catalysts are widely used for catalytic ozonation. This review describes the oxidation reaction mechanisms, reaction pathways of aromatic hydrocarbons, and dependence of the catalytic ozonation activity on the reaction conditions. The reasons why Mn oxides are effective in catalytic ozonation are also explained. The structure of the catalytic active sites and the types of supporting materials contributing to the reaction are also discussed in detail, with the aim of establishing a VOC control technology. In addition, recent progress in catalytic oxidation processes using ozone as an oxidant has been outlined, focusing on catalyst materials and reaction conditions.
Incorporating findings from a vaccine refusal study to develop a community play to improve knowledge on maternal vaccines in rural Kilifi, Kenya
Authors: Kiyuka Patience Kerubo , Onsomu Rodgers , Mutua Meshack Nzesei , Mumba Noni , Shauri Halimu
Published: March 2024

Background: Innovative approaches are urgently needed to address the growing concern of vaccine hesitancy. Used effectively, community theatre has the potential to promote health knowledge and behaviour change as it encourages community dialogues and information sharing.
Methods: This project was conducted between May 2020 and Feb 2021. We used research findings from a vaccine hesitancy study to develop a community play on maternal vaccines. The development of the script for the play was an iterative process between a local community theatre group and the research team.
Results: After taking into consideration feedback from the relevant stakeholders, we produced a community play that sought to address concerns around maternal vaccines. The resulting play was entertaining and culturally relevant and conveyed the message in a simple and clear manner using the local language.
Conclusions: Research-based theatre provides innovative ways to improve public understanding of maternal vaccines. Researchers in similar settings may find our drama relevant and adaptable.
Catalysis Properties of TiO2 Nanofibers in CO2 Conversion: A Comparative Analysis of Polymer Matrices
Authors: Gehlot Karan , Kothari Anil Chandra , Tiwari Sangeeta , Bal Rajaram , Tiwari Sandeep Kumar
Published: March 2024

The quest for efficient and sustainable methods to mitigate Carbon Dioxide (CO2) emissions is a pressing global challenge. This study delves into the crucial role of polymers in tailoring the performance of Titanium Dioxide (TiO2) nanofibers for CO2 conversion reactions. By systematically comparing the influence of different polymers, specifically Polyvinyl Pyrrolidone (PVP) and Polyvinylidene Fluoride (PVDF), on the CO2 conversion activity of TiO2-NFs, we shed light on the remarkable potential of polymeric selection to fine-tune catalyst properties. The paper uses advanced experimental techniques to analyze the structural and morphological properties of PVP-TiO2-NFs and PVDF- TiO2-NFs demonstrating their various morphologies. The investigation involves SEM, TEM, XRD, BET and UV-Vis spectroscopy to better understand the charge separation and recombination processes involved in both materials' CO2 conversion. The results show considerable differences, choice of polymer significantly impacts the CO2 conversion performance of TiO2-NFs. PVP based NFs exhibit enhanced surface area and porosity, resulting in superior catalytic activity, while PVDF based NFs demonstrate remarkable stability. These findings pave the way for innovative approaches to tackle climate change and develop a more environmentally friendly future by advancing energy-efficient and long-lasting photocatalytic technology.
Optimization of SBR Biological Treatment System and Advanced Oxidation for Non-Biodegradable Gray Water Treatment
Authors: Govahi Saeid , Derikvand Ehsan , Khoshnavaz Saeb , Babarsad Mohsen Solimani , Parseh Iman
Published: March 2024

This study investigates the treatment of gray water with high detergent content through a combination system of sequential batch reactor (SBR) and UV/H2O2 chemical oxidation. Preliminary analysis showed COD, BOD, TP and TKN levels of 600, 200, 4 and 15 mg/L respectively. As a result of SBR treatment, BOD5 decreased from 270 to 40 mg/L and COD from 600 to 162 mg/L. Activated carbon powder showed the least effect on pollutant removal efficiency. The optimal concentration of H2O2 was 12 mg/L and the duration of 3 hours for chemical oxidation was determined. The duration of aerobic and anaerobic SBR more than 4 and 2 hours, respectively, had negligible effects on pollutant removal. The combined SBR and chemical oxidation system achieved removal efficiencies of 90.6, 85, 82.5, and 65% for COD, BOD, TP, and TKN, respectively. Placing chemical oxidation before biological treatment increased organic compound removal by 6% because chemical oxidation increased biodegradable compounds. In addition, using an anaerobic unit to remove phosphorus before aeration was effective, more than two hours of anaerobic treatment had no effect on the removal of dissolved phosphorus.
Cervical cancer lymphovascular infiltration determination and tumor-associated macrophage enhancing immune escape microenvironment analysis
Authors: Guan Liming , Xu Xuexiang , Xu Junhao , Xu Gang , Zhang Yunzhu , Xia Haitao
Published: March 2024

Background:Lymphovascular infiltration(LVI) reduced cervical cancer patients overall survival(OS),while it was not easily discovered by routine HE staining,while the role of tumor-associated macrophages(TAMs) in this course need define.
Methods: Early stage cervical cancer patients were received carbon nanoparticles(CNP) for sentinel lymph nodes(SLNs) mapping,laparotomy pelvic lymph node dissection and radical hysterectomy.The samples were detected for ultra staging,cocktail double immunohistochemical(IHC) staining,Western blot anlysis.Single cell data from(GEO) for cervical cancer were obtained and analysis.
Results: The combine of CNP mapping,ultra staging and double IHC staining enhance determining ratio for tumor LVI than that of HE staining alone(41.8% (41/98) vs. 20.4% (20/98), P=0.046)).
When the number of vascular invasion foci>2.0,or the number of cancer emboli cells ≥5.0, there was negative correlation with the OS for patients (p < 0.05).
More M2 macrophage emerged surrounding the tumor vasculature than surroungding normal cervix(P<0.05).Western blot analysis,TAMs related genes MMP2,SPARC and GNLY expessed higher level in tumor, while the OS of the patients decreased accordingly.
Single cell data were screened, reduced dimensions, and constructed pseudo-trajectories. Differentially expressed genes (DEGs) analysis showed, M2 macrophage clusters related genes expession level MMP2,SPARC and GNLY were obviosely higher than that of M1 clusters in cervical cancer; M1/M2 ratio decreased significantly. MMP2,GNLY could destroy tumor vasculauture basement membrane; SPARC anti-adhesion, played a key role in EMT and tumor invasion.
M1 macrophages cluster anti-inflammatory, immune surveillance and anti-immune escape scores were obviously higher than that of M2 macrophages cluster.
Gene Ontology(GO) analysis showed innate immune response gene expression for M2 macrophage clusters decreased obviously than that of M1 macrophages.Kyoto Encyclopedia of Genes and Genomes(KEGG) showed that normal cervix and precancerous lesions higher enrichement of M1 macrophage clusters, presenting positive regulation of response stimulus signaling pathway,while cervical cancer and metastatic lymph nodes enriched M2 clusters presenting negative regulation to these signaling pathway.
Conclusions:CNP mapping could be as a SLN tracer in early cervical cancer LVI screening.Cocktail double IHC staining could enhance diagnostic efficiency than HE staining in determining LVI. M2 TAMs activity increased from precancerous lesions to cervical cancer forming a immunosuppressive envioment gradually, TAMs related genes could play a key role in this process.
Association between Sex Hormones and Erectile Dysfunction in Men without Hypogonadism
Authors: Fujita Naoki , Okamoto Teppei , Yamamoto Hayato , Yoneyama Takahiro , Hashimoto Yasuhiro , Mikami Tatsuya , Itoh Ken , Ohyama Chikara , Hatakeyama Shingo
Published: March 2024

In addition to testosterone, various endocrine hormones, such as dehydroepiandrosterone sulfate (DHEA-S) and estradiol, may be involved in erectile function. However, the role of these sex hormones in the erectile function of men without hypogonadism remains unclear. This cross-sectional study included 398 community-dwelling men without hypogonadism. The participants were categorized into the non-ED and ED groups. Multivariable logistic regression analyses were performed to investigate the relationship between ED and serum sex hormone levels, including total testosterone, DHEA-S, estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin. Among the 398 men, 66 (17%) and 332 (83%) were categorized into the non-ED and ED groups, respectively. In the multivariable analyses, serum DHEA-S and estradiol levels were significantly associated with ED (odds ratio [OR]: 0.996, P = 0.030; OR: 1.082, P = 0.002; respectively), whereas serum total testosterone, LH, FSH, and prolactin levels did not demonstrate significant association. After adjusting for age, none of neutrophil-to-lymphocyte ratio, serum plasminogen activator inhibitor-1 levels, and skin advanced glycation end-products levels demonstrated significant correlation with serum DHEA-S and estradiol levels. In conclusion, lower testosterone levels did not affect ED in men with normal testosterone levels, whereas serum DHEA-S and estradiol levels were significantly associated with ED.
Concentration and Geospatial Modelling of Health Development Offices' Accessibility for the Total and Elderly Populations in Hungary
Authors: Domjan Peter , Angyal Viola , Vingender Istvan
Published: March 2024

Background
This study examines the availability and national distribution of Health Development Offices (HDOs; N = 108) in Hungary, with an emphasis on their role in health prevention for the general and elderly population. HDOs play a crucial role in providing preventive services (nutrition, physical activity, mental hygiene), a significant factor in the health preservation of the elderly. The geographical location and accessibility of these Offices are essential parameters as they influence individual participation willingness.
Methods
Leveraging advanced geospatial modelling techniques with QGIS 3.34.0 and MS Excel software, we mapped the locations of HDOs relative to population centres, employing statistical tools such as the Lorenz curve and Gini index, LQ index, and Herfindahl-Hirschman Index. These methods allowed for a nuanced analysis of service concentration and the identification of geographic disparities in service provision. The stochastic relationship between the population and the number of HDOs was analysed through linear regression. This spatial and demographic study was based on 2022 data.
Results
The number of HDOs did not indicate significant spatial concentration relative to the population, although the Entropy Index measured substantial diversity among the counties. Based on the measured LQ Index values, it can be stated that the presence of HDOs is underrepresented in the capital and its surroundings, as well as in several counties. Additionally, our regression analysis indicated that an increase in population size does not necessarily equate to an increase in the number of HDOs.
Conclusion
The examination of geocoordinates through scatter plots, indicated a broad spectrum of dispersion, and the placement of HDOs on the map revealed a star topology. From the findings of our research, it can be concluded that the Hungarian network of Health Development Offices (N = 108) can meet the preventive health needs of both the general and the elderly population. Enhancing the geographical spread of HDOs is crucial for improving the accessibility and effectiveness of health prevention strategies, especially among Hungary's aging population, thereby contributing to a more equitable health service landscape.
A novel integrated interval prediction method based on small and non-normality distributed datasets for pavement performance from the uncertainty perspective
Authors: Zuo Wei
Published: March 2024

The uncertainty prediction of pavement performance can promote intelligent highway tunnel operation and maintenance, but it encounters the challenges of small and non-normality distributed datasets. This paper proposes a novel integrated interval prediction method to overcome these shortcomings so that we can decrease the uncertainty. This paper also validates the effectiveness of the proposed method using the empirical test of pavement performance data from the Dalian Road Tunnel in Shanghai, China. The evaluated results of PINAW and PICP achieve the values of 0.2262 and 89.24%, respectively, demonstrating excellent uncertainty prediction. Furthermore, this paper applied the proposed method to other datasets, which exhibit good generalization ability and thereby be beneficial for formulating scientific maintenance decisions and achieving the maximum service benefits of road surfaces. At last, our code will be open-sourced.
Antibacterial, Antioxidant and Anticancer Activities of the Streptomyces PML5 strain isolated from Carbonate rocksin the Amazon
Authors: Chaves Karine Rodrigues do Nascimento , França Maria Lucila Texeira de Andrade , Mendes Anna Ludmylla Oliveira , Cardoso Pablício Pereira , Vasconcelos Kamila Brielle Pantoja , de Santana Raphael Carlos Ferrer , Lotufo Letícia Veras Costa , Ramos Sara Freitas de Sousa , Costa Isabella Cristhina Gonçalves , Mendes Anderson Conceição , Ferreira Lindalva Maria de Meneses Costa , Ferreira Marcelo J. Pena Ferreira J. Pena , Padilla Gabriel , Silva Silvia Katrine Rabelo da
Published: March 2024

The aim of this study was to investigate the antimicrobial and cytotoxic potential of Streptomyces sp. isolated from carbonate rock in the Amazon. The antimicrobial activity was verified by the diffusion technique in agar against pathogens such as Micrococcus lutteus ATCC 7468, Streptococcus pneumoniae ATCC700699; Proteus vulgaris ATCC 13315, Escherichia coli ATCC 10536, Acinetobacter baumanii ATCC 19606.Cytotoxic activity was investigated ​​by the inhibition of cell growth (%) of samples tested in human colorectal carcinoma cell line (HCT116), at a concentration of 10 µg/mL (mean ± SEM; n = 2). The isolate showed a broad spectrum of antimicrobial activity against test microorganisms. This isolate showed maximum antibacterial activity against Escherichia coli ATCC 10536 (13 ± 0.0 mm) and Proteus vulgaris ATCC 13315 (12.8 ± 0.29 mm) and the most resistant microorganism against antibacterial activity of this isolate was Acinetobacter baumanii ATCC 19606 (11.5 ± 1.15 mm). This metabolites was extracted by solid:liquid method with ethyl acetate organic solvent. ​​The percentage of inhibition of cell growth of the crude extract tested in a human colorectal carcinoma line (HCT116) was 96,55%. The determination of antioxidant activity by capturing the free radical ABTS had an inhibition of 35.60 ± 2.01%, while the antioxidant potential by capturing the free radical DPPH had an inhibition of 10.65 ± 1.95%. The LC-MS analysis showed the presence of four peaks, where it was identified that the absorbance of substances 5,791 and 13,556 were similar to 9,921 and 17,077, respectively; this suggests the possibility of PML 5 having a metabolic pathway synthesizing substances of the same class. The CG-MS of the extract showed the presence of 10 volatile compounds. The main compound was Cyclododecane (83.75%) compared to other bioactive compounds. These results reinforce the potential of Amazonian biodiversity, revealing that actinobacteria produce antimicrobial and cytotoxic bioactive substances of interest to the pharmaceutical industry.
Multivariate Shape analysis using modified Otsu’s method for High-Resolution Remote-Sensing Image Segmentation
Authors: R Shijitha , A Stanly Paul
Published: March 2024

The image segmentation is mentioned to as a vital practices of image processing. It is the procedure of separating or apportioning an image into portions, named segments. It is typically suitable for applications alike image compression or object identification, since for them, it is incompetent to practice the entire image. Therefore, image segmentation is employed to divide the portions from an image for additional handling. Various image segmentation methods are availed, which divide the image into numerous portions according with definite image topographies such as pixel intensity, color, texture, etc. In this study, the protuberant approaches such as local homogeneity analysis, openings and closings with reconstruction criteria and modified Otsu’s method have been utilized for image segmentation. While comparing the obtained results of local homogeneity analysis and openings and closings with reconstruction criteria, the modified Otsu’s method offers adequate outcomes for the given images with pertinent histograms. The simulation studies reveal that the modified Otsu’s method has the benefits of real time and assured anti-noise skills, the contaminant can be found accurately and made the segmentation process ease and consistent.
Evaluation of the impact of COVID-19 on hepatitis B in Henan Province and its epidemic trend based on Bayesian structured time series model
Authors: Li Xinxiao , Li Yanyan , Xu Shushuo , Wang Penghao , Hu Meng , Li Haibin
Published: March 2024

Background
There may be evidence that COVID-19 affects illness patterns. This study aimed to estimate epidemiological trends in China and to assess the effects of COVID-19 epidemic on the declines in hepatitis B (HB) case notifications.
Methods
The Bayesian structured time series (BSTS) method was used to investigate the causal effect of COVID-19 on the decline in HB cases based on the monthly incidence of HB from January 2013 to September 2022. To assess how well the BSTS algorithm performs predictions, we split the observations into various training and testing ranges.
Results
The incidence of HB in Henan was generally declining with periodicity and seasonality. The seasonal index in September and February was the smallest (0.91 and 0.93), and that in March was the largest (1.19). Due to the COVID-19 pandemic, the monthly average number of notifications of HB cases decreased by 38% (95% credible intervals [CI]: -44% ~ -31%) from January to March 2020, by 24% (95% CI: -29% ~ -17%) from January to June 2020, by 15% (95% CI: -19% ~ -9.2%) from January to December 2020, by 11% (95% CI: -15% ~ -6.7%) from January 2020 to June 2021, and by 11% (95% CI: -15% ~ -7.3%) from January 2020 to December 2021. From January 2020 to September 2022, it decreased by 12% (95% CI: -16% ~ -8.1%). From 2021 to 2022, the impact of COVID-19 on HB was attenuated. In both training and test sets, the average absolute percentage error (10.03%) generated by the BSTS model was smaller than that generated by the ARIMA model (14.4%). It was also found that the average absolute error, root mean square error, and root mean square percentage error generated by the BSTS model were smaller than ones generated by the ARIMA model. The trend of HB cases in Henan from October 2022 to December 2023 predicted by the BSTS model remained stable, with a total number of 81,650 cases (95% CI: 47,372 ~ 115,391).
Conclusions
After COVID-19 intervention, the incidence of HB in Henan decreased and exhibited clear seasonal and cyclical trends. The BSTS model outperformed the ARIMA model in predicting the HB incidence trend in Henan. This information may serve as a reference and provide technical assistance for developing strategies and actions to prevent and control HB. Take additional measures to accelerate the progress of eliminating HB.
Extraction and characterization of cellulose nanocrystals from brown seaweed Dictyota bartayreisana, J.V.Lamouroux
Authors: Murugesan Sobiya , R Radhika Rajasree S , Rajan Roopa
Published: March 2024

For the first time, cellulose nanocrystal (CNC) was derived from the biomass of brown seaweed Dictyota bartayresiana, undergoing a comprehensive process of extraction and transformation. The structural analysis, conducted via Transmission Electron Microscopy (TEM), affirmed that the resulting CNCs displayed an average width of approximately 26 nm and a length extending to 520nm long. X-ray Diffraction (XRD) analysis indicated that these extracted CNCs constituted around 62%. Fourier Transform Infrared (FTIR) spectral analysis confirmed the successive removal of non-cellulosic components through chemical treatments. Elemental analysis (CHNS) validated the presence of sulphate groups, accounting for 0.59%. Thermogravimetric Analysis (TGA) results unveiled the superior thermal stability of the extracted CNCs.
Effective Removal of Ni(II)ions from Aqueous Solutions Using Low-Cost, Eco-Friendly Natural and Modified Potato Peels
Authors: BULUT Aycan , Altunkaynak Yalçın
Published: March 2024

The objective of this investigation is to look into the potential use of trash potato peels (PP) and processed potato peels (MPP) as a solution for effectively removing Ni(II) ions extracted from aqueous solutions. The optimal working circumstances for removing Ni(II) ions from aqueous solution in PP are an initial concentration of 500 mg/L, an adsorbent dose of 0.3 g, a contact time (CT) of 100 minutes, and a solution pH of 6.21. The optimal working conditions for MPP were established to be an initial concentration of 500 mg/L, an adsorbent dosage of 0.15 g, a CT of 100 minutes, and a solution pH of 6.21. Studies were conducted at various temperatures to better understand the removal capabilities of adsorbent compounds. The removal abilities of Ni(II) ions for PP were determined to be 25.125, 29.325, and 33.112 mg/g at varied temperatures (25, 35, and 45 oC), respectively. Under the same conditions, the removal capacity of MPP was determined to be 68.965, 78.125, and 85.470 mg/g. Further investigation of the adsorption kinetics revealed that the experimental results suited the pseudo-second-order model for both PP and MPP adsorbents. Thermodynamic analyses demonstrated that the endothermic process of Ni (II) metal ion adsorption onto the adsorbents occurred spontaneously. The study found that both PP and MPP were very efficient and ecologically friendly adsorbents for removing Ni (II) ions from aqueous solutions. Their demonstrated performance highlights their potential value in sustainable wastewater treatment applications, which accord with environmentally conscious behaviors. Their high removal capacity to effectively remove metal ions, together with their ease of use, low cost, and origin as agricultural trash, make them potential adsorbents for long-term uses in both water purification and environmental cleanup.
Directions and prospects for the development of health resort tourism in Poland
Authors: Soroka Andrzej , Godlewska Agnieszka
Published: March 2024

Background: The objective of the study was to evaluate the current level of the functioning of health resort tourism, and identify factors which exert the greatest influence on this type of tourism. The authors attempted to determine the tasks and directions of the development of health resort tourism, and define factors which may have the greatest positive impact on the standards they provide.
Materials and methods. Of the 258 health resorts, 154 establishments were selected for research purposes taking into account a proportional distribution of health resorts throughout Poland. An authorial questionnaire was developed and it included five questions with multiple answers, each answer being assessed on a 5-point Likert scale.
Results. Younger people expect a high standard of holiday resort infrastructure and better conditions for disabled people. The older the respondents are, the more likely they are to seek diverse forms of active relaxation which affect the physical and mental condition as well as regeneration of the body.
Conclusions. The awareness of the Polish society that healthy lifestyle is a necessity is increasing and is related to the age of treatment-seekers, their state of health and needs, which confirms the validity of the study reported here. The segmentation of customer profile obtained in the study reported here and individual monitoring ought to be systematic as this is the only way to evaluate the functioning, level and needs of visitors, and strengthen the potential of health resorts.