bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydroxytyrosol affects antioxidant Nrf2 expression in the kidneys of diabetic rats
Authors: Soylu Hakan , Karaçor Kayıhan
Published: April 2024

Aim: Diabetic nephropathy is the result of oxidative stress caused by chronic hyperglycemia. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that responds to oxidative stress. Nrf2 relieves oxidative stress, inflammation, and fibrosis associated with diabetes in the kidneys. In this study, we investigated the effects of hydroxytyrosol, which is a polyphenolic compound with proven antioxidant activity, on Nrf2 expression in diabetic kidneys.
Methods: Forty male Wistar rats were used in our study and the rats were divided into four groups as control (sterile water only), hydroxytyrosol (HT) (10mg/kg hydroxytyrosol administered intraperitoneally (ip) for 30 days), streptozotocin (STZ) (diabetes was induced by administering a single dose of 55 mg/kg streptozotocin ip), and streptozotocin + hydroxytyrosol (STZ+HT) (single dose of 55 mg/kg streptozotocin and 10 mg/kg hydroxytyrosol administered ip for 30 days). At the end of the study, Nrf2 expression in kidney tissue was evaluated by immunohistochemistry and Western blot.
Results: Immunohistochemistry and Western blot findings of Nrf2 were similar. It was found that while Nrf2 expression increased significantly in the HT group compared to the control group, whereas it decreased significantly in the STZ group (p<0.001). In the STZ+HT group, Nrf2 expression was found to be significantly increased compared to the STZ group (p<0.001).
Conclusions: It was found that hydroxytyrosol with known antioxidant activity increased Nrf2 expression in diabetic rats. These results suggest that hydroxytyrosol may mitigate diabetic nephropathy by Nrf2-induced reduction in oxidative stress, inflammation, and fibrosis.
The relationship between infection parameters and urine volume in acute kidney injury
Authors: Oruç İdris , Sarı Hıdır , Eynel Eren , İnce Hasan , Yıldırım Yaşar , Aydın Emre , Yılmaz Aydın Fatma , Kadiroğlu Ali Kemal , Yılmaz Zülfükar
Published: April 2024

Aim: Acute kidney injury (AKI) is a clinical syndrome that can cause disturbances in fluid-electrolyte and acid-base balance, resulting in the accumulation of nitrogen and uremic toxins along with the loss of kidney functions within hours or days. In this study, it was aimed to retrospectively examine patients with acute kidney injury to determine whether there is a relationship between infection parameters and urine volume.
Materials and Methods: The study included a total of 144 patients with (n=74) and without infection (n=70) out of 294 patients with AKI who received treatment between 1 January 2020 and 31 December 2021 in the nephrology clinic of a tertiary university hospital.
Results: The mean age was 66.4±15.7 (range:19-95) in patients with infection and 63.8±15.2 (range:36- 93) in non-infected patients. 51.4% (n=38) of those with infection and 52.9% (n=37) of those without infection were women. There was no difference between the individuals with and without infection in terms of age and gender (p>0.05). Infection was present in 51.4% (n=74) of the patients included in the study. Urinary tract (31.3%) and respiratory tract infections (13.2%) were the most common in those with infection. A moderate negative correlation was observed between admission CRP and discharge creatinine level in patients with infection. There was no correlation between PCT and sedimentation rate, urine volume and admission/discharge creatinine level. Moderate positive correlations were found between admission/discharge PCT and admission/discharge urine volume in patients without infection. In addition, moderate negative correlations were found between admission/discharge sedimentation rate and admission urine volume.
Conclusions: No correlation was found between PCT and sediment (incoming/exit) and outflow urine volume in patients with infection.
Verificação prévia no processamento da recuperação judicial
Authors: Magalhães Rodrigo Almeida , Morais Walter Coelho de
Published: April 2024

O artigo pretende analisar a legislação das empresas em crises (Lei 11.101/2005) e as alterações propostas pela Lei 14.112/2020.  A metodologia a ser utilizada é a da finalidade de pesquisa aplicada, com objetivo exploratório, em abordagem quali-quantitativa, por método dedutivo, mediante pesquisa bibliográfica, jurisprudencial e levantamento de dados. Inicialmente é feita uma contextualização do tema, passa então para uma abordagem de índices contábeis para verificação de uma melhor sistemática de verificação da capacidade da empresa sanar sua crise econômica-financeira. Após, são apresentados dados empíricos referentes às recuperações judiciais existentes no Brasil nos últimos anos e propõe um aperfeiçoamento na legislação recuperacinal. Pretende-se, portanto, que com as ponderações apresentadas o Judiciário receba o requerimento do pedido de recuperação judicial, incluído um parecer pericial preliminar com modelos contábeis dos indicadores de insolvência, de liquidez, bem como a exposição do fluxo de caixa gerado, nos três últimos anos, pelo relatório contábil de demonstração de fluxo de caixa. Ainda, é necessário haver, no parecer pericial preliminar, a informação da riqueza gerada e distribuída por meio do balanço social, que seria o relatório contábil das demonstrações de valor adicionado.
Tributação sobre cloud computing e os tratados brasileiros contra a dupla tributação de renda
Authors: Bomfim Gilson Pacheco , da Silva Sant Anna Leonardo
Published: April 2024

O presente artigo objetiva analisar a compatibilidade da retenção de imposto de renda sobre remessas ao exterior para pagamento de atividades de cloud computing, nos casos de existência de tratado firmado pelo Brasil para evitar a bitributação de renda.  Para tanto, a investigação busca identificar a natureza jurídica das operações envolvendo computação na nuvem, bem como os objetivos, contexto e legitimidade da política fiscal internacional brasileira, especialmente no que tange à taxação em território brasileiro de valores remetidos ao exterior como royalties ou remuneração de serviços técnicos. A pesquisa utiliza a revisão da literatura especializada (revisão bibliográfica) e de documentos (Tratados, Convenções Modelos, etc.), servindo-se das metodologias dedutiva-hipotética e explicativa, com abordagem qualitativa dos dados examinados. Constatou-se que 1) a política fiscal internacional brasileira, que busca reter poderes tributários, taxando os recursos produzidos no território nacional, além de legítima, é adotada por diversos países em desenvolvimento; 2) os pagamentos envolvendo contratos de cloud computing referentes a provedores situados no estrangeiro poderão ser tributados no território nacional, quando puderem ser enquadrados nos conceitos de royalties ou de serviços técnicos/assistência técnica previstos nos compromissos firmados pelo país.
Aspectos jurídicos da Internet das Coisas (IoT) aplicada ao agronegócio no estado de Mato Grosso: em busca do desenvolvimento regional
Authors: Oliveira Bruno Bastos de , Vita Jonathan Barros , Pissolato Solange Carvalho
Published: April 2024

O presente artigo objetiva discutir juridicamente a Internet das Coisas (IoT) aplicada no agronegócio, colocando em evidência os avanços e os desafios no Estado de Mato Grosso, na perspectiva da possível implementação do desenvolvimento regional. A IoT como eixo integrador da Revolução 4.0 promete inovar o mercado brasileiro com a geração de negócios inovadores, sobretudo no campo do agronegócio. Metodologicamente foi adotada a pesquisa de cunho bibliográfico com levantamento de dados em fontes secundárias e o método descritivo para atender ao objetivo geral do estudo: descrever os avanços e os desafios da Internet das Coisas aplicada ao agronegócio no Estado de Mato Grosso. Os resultados apontaram que a IoT no agronegócio de Mato Grosso já é uma realidade, estando visível nas tecnologias das máquinas agrícolas e de produção, devendo haver a busca pela harmonização entre as exigências do crescimento econômico, agronegócio, novas tecnologias, inteligência artificial, direitos humanos e preservação do meio ambiente.
Task Analysis in Human-Computer Interaction: A Comparison between Four Task Analysis Techniques
Authors: Samia Abdalhamid  , Tahani Almabruk  , Laila Haduth  , Asma Abd Aljalil  , Rafig Almaghairbe
Published: April 2024

Task analysis is an integral part of human-computer interaction, as it permits the client to comprehend, complete, and benefit from the utilization of an interaction system. Task analysis methodologies differ based on the selected approach and the motivation behind its use. The present study aims to compare several task analysis methodologies (i.e. hierarchical task analysis, cognitive task analysis, GOMS task analysis, and emotion task analysis), initially outlining their commonalities and distinctions in structure and usability. After that, it will go into each technique's benefits and drawbacks and how well-suited it is for different jobs. The main results that have been obtained by this research are: the HTA technique is an appropriate selection when the analysis seeks to explore the connections and interdependencies among different components of the task, whereas CTA is appropriate for the analysis that necessitates a technique with an undefined structure comprising of interviews. If the analysis system seeks to identify a cognitive process with a clearly defined structure, the GOMs technique can be a superb option. Lastly, when the task analysis aims to comprehend the emotional aspects of task performance, the ETA serves as an effective instrument to employ. In terms of usability, HTA is widely utilized in the fields of task assistance design and error prediction. CTA proves to be beneficial for tasks that demand sophisticated cognitive functions, GOMS is typically employed in the creation of training tools, the design of assist frameworks, and the documentation for clients, and ETA examines how users' psychological or emotional states influence their responses to tasks as they complete them. It is advised that readers go over this comparison paper in order to obtain a better knowledge of how to select the precise strategy that can aid in finishing an assignment.
Pendekatan Geografi dalam Menangani Konflik Politik dan Ekonomi Antar Wilayah Negara
Authors: Yanuar Fachry , Sya Ahman , Zid Muhammad
Published: April 2024

Geopolitik Indonesia telah dibentuk sejak masa kerajaan Indonesia yang mulai Sriwijaya dan Majapahit. Ini membahas strategi untuk Indonesia dalam mempertahankan kepentingannya Indonesia dalam hal sosial, budaya, geografis, demografis, dan keamanan sesuai dengan tujuan negara atau cita-cita negara. Mulai dari masyarakat pribumi dalam pembentukan negara maritim geopolitik Srivijaya yang merupakan penyebaran agama dan dicantumkannya jalinan sutra di selat malaka menuju daratan utama Asia tenggara lebih ke indocina, juga Majapahit dengan sebuah negara pertanian yang berhasil menyatukan kepulauan tersebut. Aspek kewilayahan dalam ilmu geopolitik meliputi geografi wilayah suatu negara melibatkan sumber daya alam sebagai salah satu alat pemenuhan kebutuhan ekonomi. Hal itu menyebabkan masing-masing negara bersaing dalam memenangkan pasar dunia menggunakan geostrategi. Wilayah pasifik telah menciptakan kawasan ekonomi dan politik tersendiri dengan Jepang dan Amerika sebagai negara acuan perekonomian dunia. Indonesia memiliki keistimewaan diantara negara pasifik lainnya. Sebagai negara kepualauan yang terletak pada garis katulistiwa, Indonesia memiliki aset ekonomi yang melimpah berupa keanekaragaman sumber daya alam. Selain itu Indonesia menjadi jalur lalu lintas perdagangan antar negara yang sangat strategis. Fenomena tersebut membentuk konsep geoekonomi sebagai geostrategi yang dilakukan secara global. Dalam hal ini bidang kajian geoekonomi memiliki variabel-variabel perinci yang menjadi dasar analisis dalam menentukan strategi pembangunan ekonomi Indonesia agar mampu bersaing dalam pasar perdagangan internasional, variabel perinci tersebut antara lain: 1) Kepercayaan, 2) Posisi, 3) Sumber Daya, 4) Bobot Penekanan, 5) Kekuatan, 6) Struktur, 7) Basis, 8) Keamanan, 9) Komunikasi, 10) Ekspansi.
Prinsip Dasar Akuntansi Syariah: Landasan Integritas dan Transparansi dalam Keuangan Berbasis Nilai Islam
Authors: Wahyudi Amin , Rosyidah Eva
Published: April 2024

Prinsip Dasar Akuntansi Syariah merupakan kerangka kerja yang mengatur praktik keuangan dalam konteks nilai-nilai Islam. Dua prinsip utama yang menjadi pijakan dalam Akuntansi Syariah adalah integritas dan transparansi. Integritas mengacu pada kepatuhan terhadap prinsip-prinsip moral dan etika Islam, sementara transparansi menekankan keterbukaan dalam pelaporan keuangan dan komunikasi dengan pemangku kepentingan. Artikel ini menggunakan metode library research, yang juga dikenal sebagai penelitian pustaka dengn melibatkan pengumpulan data dan informasi dari berbagai sumber literatur yang relevan dan terpercaya yang terkait degan prinsip dasar akuntansi syariah: landasan integritas dan transparansi dalam keuangan berbasis nilai Islam. Dengan mengulas pentingnya integritas dan transparansi dalam konteks keuangan berbasis nilai Islam. Integritas nilai kepatuhan syariah mendorong entitas untuk menjalankan praktik keuangan yang sesuai dengan prinsip-prinsip Islam, sementara transparansi keterbukaan informasi memastikan bahwa semua pemangku kepentingan memiliki akses yang sama terhadap informasi yang relevan.
Analisis Learning Trajectory dalam Konsep Pengurangan pada Pembelajaran Matematika Kelas 2 Sekolah Dasar
Authors: Muliatin Dwi
Published: April 2024

Penelitian ini dilatarbelakangi oleh masih banyaknya peserta didik kelas 2 yang mengalami kesulitan dalam memahami konsep pengurangan dan melakukan operasi pengurangan. Hal ini menyebabkan peserta didik akan mengalami kesulitan di saat mengerjakan soal-soal yang lebih rumit di jenjang yang lebih tinggi. Hal ini mendorong peneliti untuk mencari tahu penyebab peserta didik mengalami hal tersebut, dengan menggunakan Learning Trajectory pada pengurangan. Peneliti menggunakan pendekatan kualitatif serta menggunakan design research pembelajaran untuk membuat Alternatif Desain Didaktis konsep pengurangan. Pengumpulan data dilakukan dengan menggunakan teknik dokumentasi, tes dan observasi. Analisis datanya dilakukan dengan melakukan tiga tahapan DDR yaitu pada saat sebelum pembelajaran dilakukan (Prospective Analysis), pada saat pembelajaran berlangsung (Metapedia Didactical Analysis), dan setelah pembelajaran (Retrospective Analysis). Hasil dari penelitian ini berupa: (1) hypothetical learning trajectory yang dirancang menjadi delapan situasi didaktis, (2) ditemukan 4 tahapan Learning Trajectory yang jarang diajarkan oleh guru yaitu: Subitizing, Number Sense, Composing dan Part-Part Whole (Kelompok-Anggota) dan Strategi berhitung (Double Number) (3) alternatif desain didaktis konsep pengurangan yang mempertimbangkan 3 faktor yaitu: kemampuan awal peserta didik yang menjadi prasyarat, perencanaan dan tindakan guru sebagai scaffolding, serta media pembelajaran sebagai penghubung kongkrit dan abstrak.
Pengaruh Penerapan E-Filing, E-Billing, Sanksi Perpajakan dan Pemadanan NIK terhadap Kepatuhan Wajib Pajak Orang Pribadi pada KPP Pratama Sidoarjo Selatan
Authors: Asnifah Siti , Fahriani Dian
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh penerapan E-Filing, E-Billing, Sanksi Perpajakan, dan Pemadanan NIK terhadap kepatuhan wajib pajak orang pribadi di KPP Pratama Sidoarjo Selatan. Penelitian ini dilaksanakan dengan menggunakan metode kuantitaif deskriptif. Populasi dalam penelitian ini adalah wajib pajak orang pribadi yang wajib lapor di wilayah KPP Pratama Sidoarjo Selatan yang berjumlah 61.813 Wajib pajak. Teknik pengambilan sampel pada penelitian ini menggunakan metode Nonprobability Sampling, sedangkan cara pengambilan sampel yang digunakan adalah teknik Purposive Sampling dengan menggunakan sampel sejumlah 57 wajib pajak orang pribadi. Penelitian ini menggunakan beberapa uji, yakni uji statistik deskriptif, uji validitas, uji reliabilitas, uji normalitas, uji heteroskedatisitas, uji multikolinieritas, uji regresi linier berganda, uji koefisien determinasi (r-square), dan uji f dan uji t dengan menggunakan software SPSS (Statistica Product and Service Solutions) versi 24. Hasil penelitian ini menunjukkan bahwa Penerapan E-Filing dan Pemadanan NIK berpengaruh positif dan signifikan terhadap Kepatuhan Wajib Pajak Orang Pribadi di KPP Pratama Sidoarjo Selatan. Penerapan E-Billing dan Sanksi Perpajakan tidak berpengaruh positif dan signifikan terhadap Kepatuhan Wajib Pajak Orang Pribadi di KPP Pratama Sidoarjo Selatan. Penerapan E-Filing, E-Billing, Sanksi Perpajakan dan Pemadanan NIK secara simultan terhadap Kepatuhan Wajib Pajak Orang Pribadi di KPP Pratama Sidoarjo Selatan.
Pengaruh Media Komik Digital terhadap Kemampuan Menulis Cerita di Sekolah Dasar
Authors: Fibiyanti Herlina , Nuroh Ermawati Zulikhatin
Published: April 2024

Penelitian ini bertujuan untuk mengetahui adanya pengaruh media komik digital terhadap kemampuan menulis cerita di sekolah dasar. Penelitian dilakukan di SDN Kenongo 1 tahun ajaran 2023/2024 dengan pembelajaran menulis cerita mata pelajaran Bahasa Indonesia semester 1 fase B. Jenis penelitian ini yaitu kuantitatif dengan menggunakan jenis eksperimen atau pre-experimental design dengan one group pre test and post test. Sample berjumlah 22 siswa. Teknik pengumpulan data menggunakan metode tes untuk mengetahui hasil menulis cerita yaitu berupa  pre-test dan post-test untuk mengetahui seberapa besar pengaruh media komik digital terhadap kemampuan menulis cerita di sekolah dasar. Berdasarkan descriptive statistic kemampuan menulis cerita nilai mean pre test 58,64 sedangkan post test 80,59 yang berarti mengalami peningkatan selanjutnya dilakukan analisis data menggunakan uji normalitas dengan hasil data bersifat normal dan uji paired sample t-test dari hasil nilai pre test dan post test dan menghasilan sig (2-tailed) 0,00 dimana lebih kecil dari 0,05 dan dapat disimpulkan bahwa terdapat pengaruh dari media komik digital terhadap kemapuan menulis cerita di sekolah dasar kelas IV-B SDN Kenongo 1.
Pengaruh Literasi Keuangan dan Pendapatan Orang Tua terhadap Perilaku Konsumtif dengan Gaya Hidup Sebagai Variabel Moderasi Siswa SMAN 1 Benai
Authors: Triana Chici Lady , Gusnardi Gusnardi , Trisnawati Fenny
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh literasi keuangan dan pendapatan orang tua terhadap perilaku konsumtif dengan gaya hidup sebagai variabel moderasi siswa SMAN 1 Benai. Hal yang melatar belakangi penelitian ini adalah   tingginya perilaku konsumtif remaja pada saat ini. Penelitian ini termasuk ke dalam penelitian deskriptif. Populasi penelitian ini adalah siswa kelas XI SMAN 1 Benai dengan jumlah 150 dan sampel 105. Teknik penentuan ukuran sampel dapat dilihat dari tabel Isaac & Michael. Teknik pengumpulan data yang digunakan adalah kuisioner. teknik analisis data dengan analisis deskriptif kuantitatif. Berdasarkan hasil penelitian, literasi keuangan berpengaruh positif terhadap perilaku konsumtif, pendapatan orang tua tidak berpengaruh positif terhadap perilaku konsumtif, gaya hidup sebagai pemoderasi dapat memperlemah hubungan antara literasi keuangan terhadap perilaku konsumtif dan gaya hidup sebagai pemoderasi dapat memperlemah hubungan antara pendapatan orang tua terhadap perilaku konsumtif.
TEKNOLOJİK DÖNÜŞÜMLER VE YENİ ÇAĞ DİNSELLİKLERİ
Authors: Arslan Kübra
Published: April 2024

Gelişen teknolojilerin toplumsal hayat üzerindeki etkileri geniş bir inceleme alanı imkânı sunmaktadır. Sanayi Devrimi’nden bu yana makinelerin hayatımızdaki yeri yadsınamaz ölçüde artmaktayken toplumun yapıtaşlarından birini oluşturan kurumlardan din de değişen ve dönüşen anlam dünyalarıyla sosyal değişme serüveninde bu etkiden nasibini almaktadır. Bu düşüncelerden hareketle teknolojik gelişmeler bağlamında, dinin insan yaşamı üzerindeki belirleyiciliğinin geri planda kaldığı söylenebilmektedir. Sekülerleşme hareketleri doğrultusunda cemaat bazlı toplu dinî ibadetlerin/dinî ritüellerin yerini bireysel inanç ve ritüellere bıraktığı; içinde bulunduğumuz dünyayı ve ölümden sonraki hayatı anlamaya ve açıklamaya yönelik çabaların ruhani/manevi birtakım açıklamalar yerine bilimsel ve teknolojik rasyonel kimi yanıtlar bulduğu günümüz dünyasında artık dinin bireyselleşmesinden ve yeni çağ inançlarının ortaya çıkmasından da söz etmek mümkündür. Dinî kimliklerin bu şekilde sanal düzlemde akışkan bir hâl kazanması dolayısıyla dinin geleceğine yönelik birtakım soru ve sorunlar gündeme getirilerek bu çalışma içerisinde tartışmaya açılmaktadır. Bu kapsamda çalışmanın amacı ise, modernleşmenin bir uzantısı olarak da değerlendirilen sekülerleşme ekseninde teknolojik dönüşümlerle uyumlu olarak dinin sanal düzlemde geçirdiği simgesel dönüşümleri ele almaktır. Bu incelemeler yapılırken klasik ve çağdaş kuramcıların din üzerine olan yorumlarından hareket edilmiş olup çalışmada söz konusu çerçevede oluşturulmuş olan yerli ve yabancı literatüre dayalı olarak mesele çok boyutlu bir şekilde irdelenmiştir. Değerlendirmeler sonucunda görülmektedir ki dinler ve dinî birtakım ritüeller teknolojik değişim ve dönüşümler sonrası farklı formlarda varlıklarını sürdürürken dünyayı anlama ve açıklama çabalarına kaynaklık etmeye devam etmektedir. Ancak bu süreçte simgesel bir inşa sürecinden geçmekte ve ortaya teknolojik bir dinsellik modeli çıkmaktadır.
THE INFLUENCE OF ELEMENTS OF CULTIVATION TECHNOLOGY ON THE SOWING QUALITIES AND YIELD OF SPRING RAPESEED GRAIN IN THE CONDITIONS OF NORTHERN KAZAKHSTAN
Authors: Priemyshev V. S. , Shayakhmetova A. S.
Published: April 2024

Rapeseed plays a key role in various fields, including the food and feed industry, technical applications, as well as in agrotechnical and environmental terms. The diversity of agricultural production highlights the economic benefits and relevance of introducing new promising varieties and hybrids of oilseeds, including spring rapeseed. In this process, the research and selection of suitable varieties and hybrids plays a key role.The article is aimed at conducting a comparative analysis of varieties and hybrids of spring rapeseed through competitive variety testing in order to identify their productivity potential in the conditions of our region. The research process was based on two-year work within the framework of the Esil grain feed State Variety testing site. To achieve this goal, a number of tasks have been considered: studying the percentage of germination and seed safety, assessing the yield structure and productivity of various varieties and hybrids. The object of the study was varieties and hybrids of spring rapeseed.The research findings will be key to determining the most promising and economically profitable varieties and hybrids of spring rapeseed adapted to the conditions of our region.The conclusions contain estimated information on the most promising varieties and hybrids for cultivation in our region.
INNOVATIONS IN FINANCE: HOW PROCESS ROBOTICS TECHNOLOGIES ARE CHANGING THE ROLE OF AN ACCOUNTANT
Authors: Bagramova M. K. , Dudina A. V. , Sizikova K. A. , Abdrakhmanova N. B.
Published: April 2024

This article examines the impact of innovative robotics technologies on the financial sector, focusing on changes in the role of an accountant. It explores how automation of accounting processes not only optimizes routine tasks, but also opens up new opportunities for accountants in the form of strategic analysis and decisionmaking. The article also highlights the importance of adapting and developing new skills in the context of digital transformation. It is necessary to understand that today robotization technologies are shaping the future of the accounting profession in the modern financial landscape.
WASTEWATER TREATMENT OF THE TEKELI PROCESSING PLANT BY SORPTION METHOD
Authors: Dzhetimov M. A.
Published: April 2024

The article discusses the current environmental problems arising from the pollution of water resources by the metallurgical enterprise "Tekeli Mining and Processing Plant LLP" in the industrial single-industry town of Tekeli, Zhetisu region. To reveal the content of the topic, the results of a study of the impact of industrial wastewater concentrated on the areas of an operating mining enterprise on pollution of the Karatal River basin are presented. This is due to the fact that harmful compounds released by the.Tekeli mining and Processing plant cause serious environmental problems due to contamination of groundwater and surface waters of the region with heavy metals. This is influenced by the imperfection of mining methods for polymetallic ores, as well as contamination of surface and groundwater is thawed by snow and rainwater from chemical elements and harmful compounds contained in the dumps of loose rocks, which are continuously collected directly at production sites.
BERPIKIR KRITIS DALAM PROSES KEPERAWATAN: SCOPING REVIEW
Authors: Nilaprapti Endhang , Haryanto Haryanto , Bhakti Wida Kuswida
Published: April 2024

Berpikir kritis sangat diperlukan di area keperawatan baik Pendidikan maupun area klinis karena perawat dapat menggunakannya saat mengambil keputusan untuk melakukan,menolak atau menunda tindakan.. Kemampuan berpikir perawat sangat mempengaruhi kualitas pelayanan keperawatan yang diberikan dan kepuasan pasien. Artikel ini bertujuan untuk mendapatkan gambaran berpikir kritis dalam proses keperawatan. Studi ini menggunakan model Arksey dan O'Malley dalam melakukan analisis. Literatur yang dilakukan analisis terdiri dari Science Direct, Google Scholar,dan Pubmed dari tahun 2018 - 2023. Identifikasi dan pemilihan literatur menggunakan Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Moher 2009. Hasilnya sebanyak 5 artikel yang dilakukan analisis. Artikel ini merangkum temuan tentang berpikir kritis dalam proses keperawatan. Dengan berpikir kritis, perawat dapat menggali informasi pasien secara mendalam, mengidentifikasi kebutuhan Kesehatan pasien dengan akurat, dan membuat keputusan yang tepat dalam pelaksanaan dan dokumentasi asuhan keperawatan. Berpikir kritis juga memainkan peran penting dalam analisis data klinis, evaluasi efektifitas perawatan, serta pengelolaan resiko dan keamanan pasien. Lebih dari itu berpikir kritis memungkinkan perawat untuk berkolaborasi secara efektif dengan tim perawatan, mengadaptasi perawatan sesuai perubahan kondisi pasien, dan secara terus-menerus belajar untuk menigkatkan kualitas asuhan keperawatan yang diberikan. Secara keseluruhan berpikir kritis merupakan keterampilan yang esensial yang memperkaya praktik keperawatan dengan memastikan pelayanan yang holistic, tepat, sesuai dengan standar etika serta kebutuhan unik pasien.
IDENTIFIKASI DIAGNOSIS KEPERAWATAN PADA PASIEN GAGAL JANTUNG KONGESTIF
Authors: Apriyani Heni , Taufiq Ihsan
Published: April 2024

Penyakit Tidak Menular (PTM) menjadi masalah penting di dunia termasuk di Indonesia. Salah satu penyakit jantung yang dialami masyarakat adalah Penyakit Gagal Jantung Kongestif. Pasien dengan penyakit ini mengalami ketidakmampuan mendistribusikan darah secara adekuat sehingga menimbulkan keluhan merasa letih, sesak napas, nadi cepat, mudah lelah saat aktivitas, dan retensi cairan. Selama ini diagnosis keperawatan yang ditegakkan oleh perawat di RS adalah pola napas tidak efektif dan intoleransi aktivitas. Perawat menegakkan diagnosis keperawatan berdasarkan kebiasaan dan belum ada penelitian terkait diagnosis keperawatan yang dialami pasien dengan gangguan pada jantung. Penegakan diagnosis keperawatan merupakan hal yang sangat penting dalam proses keperawatan. Tujuan penelitian adalah untuk mengidentifikasi diagnosis keperawatan apa saja yang muncul pada pasien CHF di sebuah RS Tipe C di daerah Lampung. Rancangan penelitian adalah deskriptif. Sampel pada penelitian ini adalah pasien Gagal Jantung Kongestif, dengan teknik pengambilan sampel consecutive sampling, pada 60 responden. Kriteria inklusi responden terpilih adalah dengan diagnosa medik gagal Jantung Kongestif. Instrumen yang digunakan adalah kuesioner berisi data subjektif dan objektif berupa keluhan pasien untuk penegakan diagnosa keperawatan. Data selanjutnya diolah dengan mengitung prosentase diagnosa keperawatan yang banyak dialami oleh responden. Hasil penelitian menunjukkan bahwa diagnosis keperawatan Penurunan curah jantung dialami oleh 100% responden, Keletihan dialami oleh 100% responden, Intoleransi aktivitas dialami oleh 100% responden, Pola napas tidak efektif dialami oleh 80% responden, Hipervolemia dialami oleh 50% responden dan Ansietas dialami oleh 80% responden.Diagnosis keperawatan yang ditegakkan merupakan dasar utuk perencanaan keperawatan selanjutnya.
HUBUNGAN SIKAP DENGAN KESIAPSIAGAAN KELUARGA MENGHADAPI BENCANA: A CROSS-SECTIONAL STUDY
Authors: Farilya Mita , Nurmansyah Nurmansyah
Published: April 2024

Bencana menimbulkan kematian, kerugian materil dan kesakitan. Kesiapsiagaan merupakan langkah awal untuk mengurangi dan menghilangkan keparahan bencana. Kesiapsiagaan keluarga diperlukan untuk menurunkan risiko dan dampak yang ditimbulkan dengan mempersiapkan masyarakat melalui pengembangan rencana tanggap darurat, dan meningkatkan kesadaran masyarakat yang berkelanjutan. Dukungan anggota keluarga dalam perencanaan kesiapan keluarga menghadapi bencana di masa depan mampu memberikan dorongan untuk dapat merespon secara efektif saat terjadi bencana. Mengintegrasikan nilai-nilai lokal, berbagi pengalaman dan kenangan lokal dalam strategi komunikasi dan pedoman perilaku, efektif mendorong kesiapsiagaan bencana masyarakat. Tujuan: penelitian ini untuk mengetahui hubungan sikap dengan kesiapsiagaan keluarga menghadapi bencana di Desa Labuan Mapin Kecamatan Alas Barat Kabupaten Sumbawa. Penelitian ini menggunakan pendekatan cross sectional dengan 150 Kepala Keluarga di Desa Labuan Mapin sebagai responden. Metode pengambilan sampel adalah purposive sampling. Uji Spearman rank menunjukkan p value 0,000 dengan α 0,05 yang berarti ada korelasi yang signifikan antara variabel sikap terhadap kesiapsiagaan keluarga. Hasil penelitian menunjukkan sikap terbukti berhubungan dengan kesiapsiagaan keluarga menghadapi bencana.
Constructing evaluation criteria for university lecturers' competencies: Measures to enhance the quality of faculty at Tan Trao University, Tuyen Quang Province, Vietnam
Authors: Tuyet Mai Hoang Thi
Published: April 2024

In the realm of higher education, the faculty plays an exceedingly vital role in shaping the quality of university education. Assessing the quality of higher education involves considerations across various standards such as program quality, infrastructure quality, teaching staff, student support personnel, and quality improvement measures. Among these, constructing a faculty team that ensures both quantity and quality to meet training needs and accomplish strategic objectives of each university is regarded as a paramount requirement. Evaluating faculty competencies is deemed a compulsory requirement for gauging the educational quality of contemporary universities. Faculty competency assessment is conducted based on multiple criteria, among which teaching proficiency, scientific research, and community service are recognized as three core competencies of each faculty member. This article underscores the necessity of constructing evaluation criteria for faculty competencies. Additionally, it analyzes several fundamental criteria in faculty competency assessment. Building upon this foundation, a number of solutions are proposed to implement and apply these criteria in the practical assessment of faculty competencies at Tan Trao University, Tuyen Quang Province, Vietnam.
A ESPIRITUALIDADE COMO ESTRATÉGIA DE CONTROLE DA DOR EM PACIENTES COM FIBROMIALGIA: UMA REVISÃO SISTEMÁTICA
Authors: Roque Elida Carolina Almeida , Costa Felippe Wanderley da , Silva Fernanda Gonçalves da , Martins Gabrielli César
Published: April 2024

Introdução: A fibromialgia é definida como uma síndrome dolorosa crônica que acomete cerca de 2,5% da população brasileira, de etiologia complexa, necessitando de tratamento multiprofissional. Diversos estudos propõem tratamentos alternativos, incluindo o uso da espiritualidade como alternativa para o manejo da dor. Objetivo:  Ampliar o olhar sobre as possibilidades de trabalho com pessoas nesta condição, evidenciando dificuldades, déficits e avanços encontrados e como a espiritualidade pode contribuir para o controle da dor. Materiais e métodos: Trata de uma revisão sistemática, utilizando como protocolo o modelo PICO para aprimorar as buscas nas bases de dados escolhidas, visando investigar o uso da espiritualidade como recurso no manejo da dor em pacientes com fibromialgia. Resultados: Dos 95 artigos encontrados, 13 foram selecionados após leitura na íntegra para compor o presente estudo, e apenas 23% enfatizam a fibromialgia enquanto variável. Além disso, 5 artigos abordam o conceito de coping e coping religioso. Conclusão: Há associações consistentemente positivas entre espiritualidade e qualidade de vida, mas são escassos os estudos que contemplam essa relação com a fibromialgia e é notável a falta de protocolos para guiar a atuação dos profissionais de saúde nos cuidados espirituais, sendo necessária a ampliação dos estudos neste campo.
PLATAFORMA DIGITAL DIÁLOGOS EM EDUCAÇÃO ESPECIAL: INCLUSÃO E HUMANIZAÇÃO
Authors: Lopes Bernarda Elane Madureira , Carvalho Carla Maria Nogueira de , Oliveira Cristiana Fonseca de Castro
Published: April 2024

O presente projeto de extensão vai ao encontro das demandas vividas pelas instituições educacionais que mediante conquistas na legislação vigente, pressupõe o acesso, permanência e sucesso escolar dos alunos da Educação Especial. Nosso objetivo é fomentar a formação para a Educação Especial na perspectiva da Educação Inclusiva, por meio de plataforma digital, potencializando discussões e ações que promovam a inclusão destes estudantes na escola regular. Como procedimentos metodológicos utiliza-se a oferta de minicursos, oficinas, palestras, rodas de conversa, compartilhamento de informações e materiais, podcast, além de apoio individual online, via plataforma digital. Infere-se, considerando a análise dos formulários de avaliação aplicados, estar atingindo os objetivos propostos. Pode-se afirmar que não se trata simplesmente  de um  projeto  institucionalizado  como  ação  de  extensão  de  natureza  pedagógica, mas, sim, e,  principalmente,  uma  ação  de  política  pública  que ultrapassa a  formação  e qualificação, pois resgata  a credibilidade no ser humano e a valorização da diferença, cujo lócus é a inclusão e a humanização. Representa, assim, um  caminho dereafirmação  em  torno de umauma educação democrática e na  garantia  dos  direitos.
DESAFIOS NO DIAGNÓSTICO DA DOENÇA DE ALZHEIMER, ENFOQUE NA POPULAÇÃO BRASILEIRA: UMA REVISÃO BIBLIOGRÁFICA
Authors: Silveira Neto Irineu Franco da , Santiago Lívia Barros , Montani Jean Anício , Araújo Anna Beatriz de Oliveira , Zon Luíza Fianco , Oliveira Renata de Abreu e Silva
Published: April 2024

A Doença de Alzheimer (DA) representa um desafio crescente na saúde global devido ao envelhecimento populacional acelerado. Sua prevalência aumenta conforme a idade, impactando a qualidade de vida dos pacientes e dos familiares. Esta revisão bibliográfica analisa os fatores que influenciam o diagnóstico da DA no Brasil, explorando não apenas os fatores de risco e a influência genética, mas também os progressos nos critérios diagnósticos. Além disso, enfatiza a importância da avaliação neuropsicológica na detecção precoce de sintomas cognitivos sutis, como memória e linguagem. Fatores genéticos são destacados como cruciais na determinação da DA, juntamente a outros elementos multifatoriais, como o transporte de colesterol. A combinação de critérios clínicos, neuropsicológicos e biomarcadores é essencial para um diagnóstico definitivo, especialmente considerando a proposta diagnóstica, que permite a identificação precoce da doença. Essas descobertas ressaltam a necessidade de uma abordagem abrangente e multidisciplinar para contornar o desafio crescente da DA no Brasil, especialmente dada a predominância na população idosa feminina no país.
MAKNA FRASA “JAGALAH HATI” DALAM AMSAL 4 :23 BAGI KAUM MUDA POSTMODERN
Authors: Cong Jhoni , Kati Dida Hae , Hasibuan Serepina Yoshika
Published: April 2024

Postmodern ialah era yang memunculkan sebuah pemahaman baru di kalangan kehidupan masyarakat yakni paham relativisme. Paham ini menyatakan bahwa kebenaran ialah bersifat relative, tergantung pada kondisi kehidupan. Berdasarkan pandangan paham relativisme, kebenaran Firman Allah adalah suatu hal yang tidak mutlak, sebab kebenaran menurut seseorang belum tentu kebenaran menurut orang lain. Hal ini akan membawa pengaruh negatif bagi pertumbuhan iman anak-anak muda Kristen dan dapat membuat mereka menjauh dari kebenaran yang hakiki berdasarkan pengajaran Alkitab. Oleh sebab itu, pada penelitian ini penulis meneliti bagaimana nasihat tentang menjaga hati di Amsal 4:23 dapat dimaknai dalam konteks kaum muda dalam mempertahankan imannya di era postmodern ini. Penelitian ini menggunakan metode deskriptif kualitatif dengan melakukan eksegesis ayat dan menemukan makna penting dari frasa menjaga hati. Hasil tafsiran yang ditemukan adalah menjaga hati diimplementasikan dengan berpegang teguh pada kebenaran Alkitab dan bersikap toleran tanpa mereduksi iman. Relativisme tidak bisa diterima sebelum adanya fondasi kebenaran yang kuat dalam hati kaum muda postmodern.
KAJIAN TEOLOGIS TENTANG PENGINJILAN DALAM METAVERSE SERTA APLIKASINYA DI DUNIA VIRTUAL
Authors: Susanto Owen
Published: April 2024

Mission and evangelism is a command given by the Lord Jesus. He sent His disciples to make disciples of all nations, baptizing them in the name of the Father, Son, and Holy Spirit, and teaching them to do everything the Lord Jesus had taught them. Mission and Evangelism need to be done by every believer in this modern age. Since Mark Zuckerberg announced about the metaverse, many people have planned to join and take advantage of the opportunity to do business, and seek profit for their personal life. The church should be able to see the metaverse as an opportunity for mission and evangelism, not reject it. The purpose of this study is to explain why the metaverse is an ideal platform for doing missions and evangelism, along with ways to do mission and evangelism in the metaverse. The method used is descriptive qualitative with content analysis techniques. This research is library research. The results of this study indicate that the metaverse can bring a large number of souls to God by creating an attractive virtual environment and according to the times described in the Bible and every believer can carry out missions and evangelism with the principles of experts. The conclusion of this study is that the metaverse can be used by every believer to carry out missions and evangelism, therefore, the church should not be anti-technology, but the church must use the technology, for the glory of God.
PERANAN ORANG TUA: PENGENALAN AKAN ALLAH SEJAK USIA DINI BERDASARKAN ULANGAN 6:4-7
Authors: Tan Yuliana Yuli , Sianipar Rikardo P.
Published: April 2024

The aim of this research is to determine the role of parents in introducing God from an early age based on Deuteronomy 6:4-7 and its implications for spiritual growth. Considering the important role of parents in educating, especially early childhood, which is a golden period for growth and character formation, it is necessary to introduce God to them so that they have a strong foundation for their spiritual growth in the future. The condition of teenagers is still unstable, they are easily influenced by their social environment and become involved in delinquency. It is the responsibility of parents to introduce God, teach them to love Him so that faith in Him grows and bears fruit. This research uses descriptive qualitative analytical methods with data collection procedures using observation and interviews. Data analysis techniques, namely reducing and presenting data and researchers interpreting it. The results of the research are that there are parents who educate their children using violence but also with love; Examples given in everyday life and providing guidance. The conclusion is that parents at GBI True Vine Jakarta carry out their role in educating, setting an example, and guiding their children. Showing faith in God, introducing His love. The spirituality of teenagers at GBI True Vine Jakarta grows as they get older, they have faith in Jesus and have a desire to do their best for Him.
Anesthetic Management of Mucormycosis Cases Requiring Surgical Debridement
Authors: Tuncer Bilge , Akcaalan Yasemin , Kocagil Sumeyye , Yildiz Asena Irem , Celik Fulya , Celik Burak , Erkilic Ezgi
Published: April 2024

Objective: Mucormycosis is a rare, progressive, and life-threatening fungal infection that occurs in immunocompromised patients. In the present study, we aimed to evaluate the perioperative challenges in the anesthetic management of mucormycosis patients. Methods: Patients over 18 years of age who underwent surgery for mucormycosis within a 3-year period between January 1, 2020 and December 31, 2022 were included in the study. Perioperative records were retrospectively evaluated. Results: During this period, 25 of 47 cases of mucormycosis were surgically treated. Data from these 25 cases were analyzed. Twelve (48%) patients had a diagnosis of rhinocerebral, 7 (28%) rhino-orbital, 5 (20%) rhino-orbito-cerebral and 1 (4%) rhino-pulmonary mucormycosis. All patients had comorbidities. The most common comorbidities were diabetes mellitus in 20 (80%), followed by hypertension in 12 (48%), acute kidney injury in 7 (28%) and coronary artery disease in 5 (20%) patients. Six (24%) patients had a history of COVID-19 infection and were treated with steroids. Intubation was difficult in 2 (8%) patients. Two (8%) patients had intraoperative hemodynamic instability requiring inotropes. There were 17 (68%) patients, 6 (24%) of whom were intubated, who were transferred to the intensive care unit (ICU). The median length of stay in the ICU was 22.7 days and the total length of stay was 42 days. Eleven (44%) patients required mechanical ventilation. Mortality occurred in 12 (48%) patients. Conclusion: Anesthetic management of surgical debridement for mucormycosis is challenging. Challenges include difficult intubation and renal dysfunction. Postoperative follow-up in the ICU is important due to rapid progression and comorbidities. Keywords: Mucormycosis, COVID-19, anesthesia
Comparison of the Role of Ultrasound Use in Detecting Lung Pathologies with Prognosis, Mortality and Scoring in Geriatric Critically Ill Patients in the Intensive Care Unit
Authors: Bayındır Serpil
Published: April 2024

Objective: It is crucial to correctly and promptly diagnose pulmonary diseases and to initiate treatment in elderly patients diagnosed with respiratory failure who are on mechanical ventilator support. The aim of this study is to investigate the effect of lung ultrasound (USG) on prognosis and mortality in geriatric patients we follow up in the intensive care unit, by scoring. Methods: Patients who were followed up in the intensive care unit were grouped as AUSG group (n=48), those who underwent lung USG and NAUSG group (n=74) who underwent chest radiography, computed tomography (CT), magnetic resonance imaging (MRI) or bronchoscopy. The hospital information management system was used to compare the two groups in terms of diagnosis time, number of additional consultations, treatment and discharge time, hospital stay, mortality, and scores. The arterial blood gas analysis, complete blood count, biochemistry, procalcitonin, C-reactive protein, and endotracheal aspirate culture results of the patients were recorded. The clinical pulmonary infection score, pneumonia severity index-65, pulmonary severity index, and acute physiology and chronic health evaluation 2 scores of the groups were compared. Results: The diagnosis time in Group AUSG was 1 ± 0.64 day, the treatment time was 10 ± 4.62 day, and the number of required consultations was 1 ± 0.68, which was significantly lower than in Group NAUSG (p<0.05). The mortality rate was 14 (29.2%) patients in Group AUSG and 25 (33.8%) patients in Group NAUSG (p>0.05). When comparing the scores of the patients, the clinical pulmonary infection score, pneumonia severity index-65 (4 ± 0.79), and pulmonary severity index (3 ± 0.87) were significantly lower in Group AUSG (p<0.05). There was no significant difference in acute physiology and chronic health evaluation 2 scores. Conclusion: Performing lung USG for the diagnosis and treatment of critically ill elderly patients can lead to earlier detection and treatment of lung pathologies, reducing mortality rates, unnecessary imaging and consultations. Its advantages include easy and rapid bedside application and simultaneous results. Keywords: Geriatrics, ultrasonography, lung, prognosis, mortality
Ex-Ovo Evaluation of Sevoflurane Exposure on Chick Embryo Development: Investigating Angiogenesis Effects
Authors: Ors Yildirim Nadide , Kirlangic Omer Faruk
Published: April 2024

Objective: Angiogenesis, defined as the formation of new blood vessels from pre-existing ones, plays a vital role in both physiological and pathological conditions. Understanding agents that can influence angiogenesis is crucial in managing diseases where angiogenesis is dysregulated. This study focuses on sevoflurane, a commonly used inhalation anesthetic, whose effects on angiogenesis and embryonic development are not well understood. Our objective was to assess the impact of sevoflurane exposure on angiogenesis using the ex-ovo chick chorioallantoic membrane model. Methods: In this model, fertilized chicken eggs were exposed to sevoflurane at concentrations of 2% and 4%, for varying durations of 1, 2, and 4 hours. The embryos were then divided into control and experimental groups for quantitative angiogenesis assessment using Image J software, followed by statistical analysis with one-way analysis of variance. Results: The results indicate that sevoflurane exposure has a dose-dependent positive effect on angiogenesis, with significant increases in vascular density observed in embryos exposed to both concentrations compared to the control group. Additionally, the length of exposure was found to further enhance these angiogenic effects. Conclusion: Despite the dose and duration-dependent impact of sevoflurane on angiogenesis, the existing literature presents mixed findings, highlighting the need for additional research to elucidate sevoflurane’s role in angiogenesis. This is particularly important for understanding its implications in various medical conditions, such as cancer, wound healing, and fetal development. Future investigations into sevoflurane’s effects on placental angiogenesis could also provide valuable insights into its potential consequences on intrauterine growth. Keywords: Angiogenesis, sevoflurane, chicken embryo, model organisms, ex-ovo
ЧЕТ ТИЛИН ҮЙРӨНҮҮДӨ ОЮН ТЕХНОЛОГИЯСЫ
Authors: Замалетдинова Г.С. , Эрназарова У.А. , Байжигитова А.А.
Published: April 2024

В данной статье речь идет о роли игры в процессе обучения иностранному языку в вузе. Детально продуманная и методически грамотно организованная игра облегчает прочное усвоение языкового материала, способствует его творческому использованию в речевом общении и практическом усвоении медицинской терминологии. Проанализированы основные функции игр, применяемых на занятиях по английскому языку.

Бул макалада биз жогорку окуу жайларында чет тилин окутуу учурунда оюндун ролу тууралуу сөз болуп жатат. Деталдуу ойлонулган жана методикалык жактан сабаттуу уюштурулган оюн тилдик материалды бекем өздөштүрүүнү жеңилдетет, сүйлөө байланышында жана медициналык терминологияны практикалык өздөштүрүүдө анын чыгармачыл колдонулушуна өбөлгө түзөт. Англис тили сабактарында колдонулган оюндардын негизги функциялары талданды.

The present article considers the role of the games in teaching a foreign language at the higher medical educational institution. A well-planned and methodically thought out game provides comprehensive acquisition of material being studied, mastering efficient speaking skill and promotes its creative use in speech communication and practical assimilation of medical terminology. The main functions of games implanted in classes in a foreign language for students are analyzed in this article.