bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in traffic accident risk degree according to driving workload rate and moderate effect of ego-resilience
Authors: Song HunHwa , Lee SoonChul
Published: January 2020

This research was conducted to verify changes in traffic accident risk level according to driving workload rate and the moderate effect of ego-resilience. Several hypotheses were made by considering previous studies, in which the traffic accident risk level measured according to Traffic Accident Risk Index (TARI) and Driving Behavior Determinants (DBD) differed from the driving workload rate. Furthermore, Ego-resilience was also considered as a human factor, which has the moderate effect between workload and TARI, DBD. A total of 260 drivers participated in the survey. The result of the factor analysis revealed that the DBD questionnaire could be divided into five factors (i.e., Impatient Driving, Situational Inadaptability, Distracted Driving, Drunken Driving, and Speed Driving). In order to verify changes in those behaviors according to driving workload rate, variation analysis was conducted. The results revealed that Impatient Driving, Situational Inadaptability, and Distracted Driving had significant relationships with driving workload rate. Moreover, the moderate effect of Ego-resilience related to Situational Inadaptability was verified by hierarchical regression analysis. We expect that the result of this study could be used to develop countermeasures to excessive driving workload.
The effect of organizational commitment on safety behaviors
Authors: Moon Kwangsu , Lee Jaehee , Oah Shezeen
Published: January 2020

The purpose of this study was to examine the effects of organizational commitment on safety behavior and to explore moderating effect of safety climate between organizational commitment and safety behaviors. 215 workers were asked to respond to the questionnaires that measured various demographic variables, organizational commitment, safety climate and safety behaviors. A hierarchical regression was conducted to identify variables that had significant relationships with safety behaviors and to examine moderating effect of safety climate between organizational commitment and safety behaviors. Results indicated that the emotional commitment significantly predicted both safety compliance and participation behavior and the normative commitment significantly predicted safety compliance behavior. It was found that the safety climate was also a significant predictor for both safety compliance and participation behavior. In addition, safety climate had a moderating effect on the relation between emotional commitment and safety compliance behavior and normative commitment and safety compliance and participation behavior. Based on these results, the implications of this study and suggestions for future research were discussed.
A study on the relationship between intragroup conflict and turnover intentions, and the mediating effect of job satisfaction
Authors: Lee Junho , Park Jihwan
Published: January 2020

The study delved into the impact of intragroup conflict on turnover intentions and cultural commonalities and differences in job satisfaction that mediates the relationship. To identify correlations among intragroup conflict, job satisfaction and turnover intentions for each Korean and Chinese employee, the study analyzed questionnaires used to survey Korean employees working at Korean companies and Chinese workers in Korean companies based in China. The study divided intragroup conflict into two types - relation conflict and task conflict - and looked into the impact of each conflict on turnover intentions, and found that both types of conflict heightened turnover intentions of both Korean and Chinese workers. The study also attempted to prove the mediating effects of job satisfaction on the relationship between relation conflict and task conflict, and turnover intentions. As a result, mediating effects were found only in the relationship between relation conflict and turnover intentions among Chinese employees, while Korean workers saw the same effects only in the relationship between task conflict and turnover intentions. The above-mentioned results indicate the following implications. Firstly, there were common effects of intragroup conflict on turnover intentions for both Korean and Chinese employees. Such effect can be understood from culture universal perspective. Secondly, differences emerged in the mediating effects of job satisfaction in the relationship between turnover intentions and intra-group conflicts. That is understandable from culture specific perspective. Thirdly, the result that can be inferred from the aforementioned findings is that when it comes to cross-cultural research on methods of management, it is important to consider two types of approaches - culture universal and culture specific approaches. Lastly, the study also indicated that companies operating overseas should seek both localized and global management.
PENANAMAN NILAI-NILAI MULTIKULTURALISME DALAM KURIKULUM PENDIDIKAN ISLAM:
Authors: Hannase Mulawarman , Arifah Fatwa
Published: January 2020

This article examines how to implement the values of multiculturalism in the Islamic education curriculum as an attempt to counter narrative of radicalism in various educational institutions. This study is regardly important due to currently in the development of educational curriculum, the issue of intolerance and split religious understanding has come to the attention of the government as well as society of Indonesia. This study is a qualitative by using multicuralism theory of James A. Bank's. The study confirm that multiculturalism-based learning which contains of values of togetherness, humanity, tolerance, culture and local wisdom should be adopted as an alternative to counter radical narrative in the different educational institutions.
MELAWAN TEORI OTENTISITAS HADITS
Authors: Wathani Syamsul
Published: January 2020

In the scientific tradition, the study of Islam in the orientalisme is not stagnant, but has experienced development. This article focuses on the arguments of Nabia Abbot's argument and theory in refuting Goldziher's theory of the study of hadith. The author calls it a counter discourse. At least this article found three outlines of Nabia Abbot's rebuttal to Goldziher: (a) the theory of authenticity, Goldziher said the hadith was not an authentic report but a form of doctrinal reflection during the first two centuries after the prophet Muhammad. Abbot denies he views this view as wrong because it ignores historical evidence. For Abbot the hadith had appeared early in the century, as evidenced by the oral hadith of Muawwiyah (d. 60/680), Marwan (d. 65/684) and Abd Malik bin Marwan (d. 86/705). (b) Isnad's theory. Goldziher mentioned that the growth of the hadith in the third century Hijriyah was due to the history of history and the fabrication of the hadith. Nabia Abbott has argued with the argument that the number of hadiths is due to the growth of the hadith path in the geometric progression, not forgery. (c) Hadith Writing Theory, Goldziher said that the early hadith did not have a written reference, only oral, so the hadith in the form of thoughts could not be verified. Abbot denied, he said, that the beginning had been carried out in the narration and the modification of the hadith. Besides there are a number of books of hadith as in the text of Hammâm b. Munabbih (40-131 / 132 H).
LEGISLASI ANAK BIOLOGIS
Authors: Syahriyati Laili ‘Izza
Published: January 2020

Natural child only have a nasab from his mother. Constitutional Court No.46/PUU- VIII/2010 add a child outside of marriage also connected to the biological father in civil. This provision aims to provide fair legal protection and certainty about child born. But, Indonesian Religious Leader (MUI) provide fatwa No 11/2012 about the position of the natural child and the treatment of it. This research will discuss about Hadith study is related to biological child legislation and legal content in it. The type of research is yuridis-normative. This research analizes law phenomena with nash, hadits and opinion of fiqh scholars about that. The Research result is HR.Abu Daud- 2266, HR.Bukhari ke-6319, HR.Bukhari- 4903 talk about natural child has nasab to the mother only. Next, HR.Bukhari ke-1271 about a child is always born with fitrah and can’t accept guilt of his parents. Jumhur scholars besides Hanafiyyah agreed about natural child has nasab with mother’s. But, Hanafiyyah is explain natural child have conecting nasab with biological father because his father and profeble.
TREN SOSIO-SUFISTIK DALAM TAFSIR JAWA
Authors: Wahab Abdul
Published: January 2020

Tafsir Faidl al-Rahma>n is a work of tafsir written by one of the archipelago scholars of the namely Kiai Saleh Darat, this tafsir is written using the Java language and Arabic pegon script, the goal, in addition as a mean of communication between writers and readers who are Javanese, Java language and the writing of this pegon is also a symbol of resistance against the invaders. The method used in Tafsir Faidl-al-Rahma>n is the analytical method (tah}li>li>) with the Sufistic genre or isya>ri, the Sufistic genre promoted by Kiai Saleh is very unique, because Kiai Saleh is very firm in holding principle, ie incompatibility with the Sufistic genre which is symbolic, even the genre of Sufistik that is carried by Kiai Saleh can be said as "socio-sufistik" genre, which means the nuances of sufistik contained in his tafsir always associated with the dynamics of social life that is pervasive and always applicable in the midst of social life in order to form moral religious society towards the realization of the whole human being (insa>n ka>mil). Interpreted verses are presented with a comprehensive meaning and then are explained by using the meaning of isya>ri contained in certain verses. Tradition history and also interteks also colored nuances in the interpretation of one of the scholars of this very inspiring archipelago. By using the hermeneutic approach, this research was conducted to reveal deeper thoughts and genres of Kiai Saleh's commentary in the book Faidl al-Rahma>n. A very proud and extraordinary academic work.
MENGENAL SISI KEMANUSIAAN DAN KERASULAN MUHAMMAD BIN ABDULLAH
Authors: Rahim Muhammad Rafi’iy
Published: January 2020

Analisying the personality and journey of the prophet Muhammad is an inexhaustible study. The figure of the prophet Muhammad kept a number of secrets and lessons, especially specifically aspects of humanity and prophethood. While the writings of experts related to the issue have not received much attention from Islamic scholars. This paper elaborates the life history of the prophet Muhammad, with an emphasis on aspects of his humanity and prophethood. Through searching historical data through information from hadiths that were carried out by contextualization, this paper found that the figure of the prophet Muhammad was inseparable from the figure of a highly respected prophet. In addition, it was also found that the prophet Muhammad in his daily life remained inseparable from ordinary people who could make mistakes in world affairs. While as a Prophet, he was awake from mistakes in conveying God's message. The implication in religion is to require a wise attitude in copying the behavior of the prophet.
REVIVING ECONOMIC THOUGHT BY MANNAN PERSPECTIVE
Authors: Amiruddin Muhammad Majdy , Ismail Muhammad , Hasim Hasanuddin
Published: January 2020

The reviving of modern economic theory is usually stated starting from the publication of Adam Smith's The Wealth of Natoins, in 1776, although other thinkers who first also gave no small contribution. The main idea put forward by Adam Smith is that competition between various suppliers of goods and buyers will produce the best possibilities in the distribution of goods and services because it will encourage everyoe to do the specialization and increase in capital so that it will produce more value with a permanent workforce. From the Islamic perspective, there are several names that commonly known such, Baqir, Umar Chapra, and Mannan. The purpose of this research is to explore the revival economic though by Abdul Mannan. This research adapts content analysis method, which is a researcher conducts a discussion of the contents of written or edition information in the mass media. The data analysis techniques of this scientific work use literature study techniques, comparative, induction, and deduction. The study began by collecting literature data from Muhammad Abdul Mannan's Concept of Thinking about the Development of Modern Era Islamic economics and Modern Era Islamic Economic concepts in general, (researchers only participated in the discussion). Then proceed with the interpretation that researchers try to understand Muhammad Abdul Mannan's thoughts about the Development of Islamic Economics in the Modern Era. The result of this reseacrh indicates that the revival of Islamic thought by determining basic economic functions that simply cover three functions, namely consumption, production and distribution. Those basics are rooted by Five basic principles rooted in Shariah for basic economic functions in the form of consumption functions are the principles of righteousness, cleanliness, moderation, benefit and morality
UNIVERSALITAS KETAUHIDAN TUHAN
Authors: Jannah Roudhotul
Published: January 2020

This article is about Angelika Neuwirth’s thought, dialectical of Qur’anic interpretation. She offer new view to understanding of Qur’an’s meaning. Neuwirth encourage to reunderstanding Qur’an post-canonization (a written text) with pre-canonization method (oral communication), as in Surat Al-Ikhlas. Accourding Neuwirth, Surat Al-Ikhlas responded from tradition and civilization of Arabic region earlier. An example أَحَدٌ (Q.112:1) is similiar meaning with “ehad” in Ibrani language. That’s mean usage أَحَدٌ had purpose to negotiation strategy and universality of faith. therefore Islamic religion has mission to combine all ideology of faith become unity universality. Neuwirth encourages to refer to the other holy scripture for adding comprehensive information and objective data.
KELUAR DARI TEKANAN: KONSTRUKSI GERAKAN SYI’AH DI YOGYAKARTA
Authors: Taufik Muhammad
Published: January 2020

The Sunni and Shia’s conflict was occurred during contestation between the majority and minority people. In Indonesia, Sunnis are majority which naturally had a position that would always suppress the minority, however there is a subordination of those who have power to the ruled. For this reason, for those people who have been controlled will always be controlled and oppressed, so that all activities will be limited. This issues were happened in Yogyakarta, where the Shi’a group named Rausyan Fikr was oppressed and harassed by a pressure community consisting of the Islamic Community Forum (FUI) and the Islamic Jihad Front (FJI). The pressure communities consider the Shi’a group Rausyan Fikr have spread heresy or heterodoxy which is contrary to the creed of the Sunni majority. The oppressed communities are raising theological and aqidah issues that the Shi’a of Rausyan Fikr are Shi'a rafidhah who are heretic and unbeliever. But on the other hand, the Shi’a group (Rausyan Fikr) operates in the realm of thought and philosophy, not in the theological and religious areas which are considered to be the private domain. In responding to this problem, the Shi’a group (Rausyan Fikr) could be goodin their strategy so they can get out of pressure. As a result, the Shi’a group took strategy through the spiral of silence movement by utilizing the mass media as a purpose to spread discourse that would supported their action. In addition, Rausyan Fikr develops activities that can support their mobility such as building an intellectual movement of the Islamic Philosophy Activist Network (JAKFI) which focuses on areas of science and philosophy.
NITROUS OXIDE (N2O) EMISSION AND AGRONOMIC CHARACTER ON DIFFERENT GREEN BEAN VARIETIES (Vigna radiata L.) IN UPLAND
Authors: Yulianingsih Eni , Kartikawati Rina , Wahyuni Sri
Published: January 2020

Cultivation activities on mug bean lands have the potential to cause N2O emissions. Efforts to reduce N2O emissions through the selection of low-emission mug bean varieties. The study was conducted at the Experimental Garden of the Agricultural Environment Research Institute, Jaken, Pati, Central Java, in July 2018 until October 2018. The experimental design used was a randomized block design with six replications and four mug bean varieties: (1), Gronong (2), Menthik (3), PB and (4), Vima 3. Parameters measured were flux and N2O emissions, plant height, number of leaves, number of branches, leaf greenery, weight of 100 seeds, yield of dry beans per tile, and yields. The results of the analysis showes that PB varieties produced N2O emission values for the lowest 1 (one) growing season of 0.17 kg ha-1season-1. Meanwhile, from the results of productivity, the Menthik variety has the highest average yield of dried seeds, which is 1.38 tons ha-1. PB varieties have a higher average weight of 100 seeds (6.28 grams 100 seeds-1). So, in mung bean varieties that produce low emissions, not necessarily have high productivity as well. Greenhouse gas mitigation strategies, especially to reduce N2O emissions can be done by selecting varieties, balanced by good soil treatment, and effective and efficient fertilization.
Effect of Azotobacter Application Method on Yield of Soybean (Glycine max (L.) Merill) on Dry Land
Authors: Hindersah Reginawanti , Risanti Rara Rahmantika , Haikal Ibnu , Mahfud Yuliati , Nurlaeny Nenny , Rachmadi Meddy
Published: January 2020

Biofertilizer which contain rhizobacteria Azotobacter increase soil fertility and improve plant growth through nitrogen fixation and phytohormone production. The objective of this study was to compare the responses of soybean (Glycine max (L.) Merill) plants in dry land after the application of several Azotobacter inoculation methods. Field experiments were carried out with a randomized block design consisting of five treatments with five replicates each. The treatments were seed inoculation, soil treatment before planting, soil treatment after planting and plant dressing. Plant inoculation with Azotobacter treated with half of recommended dosage urea  while the control plant received recommended dose urea. The experimental results showed that all application methods did not affect soybean production, number of nodules, Azotobacter populations in the rhizosphere and N total soil; but Azotobacter inoculation through leaves increased N uptake and weight of 100 soybean seeds.
FARMER PREFERENCES FOR SHALLOT VARIETIES: EVIDENCE FROM PASIR VILLAGE, MIJEN DISTRIC DEMAK REGENCY
Authors: Awami Shofia Nur , Wahyuningsih Sri , Rina Rina
Published: January 2020

Mijen district is the highest shallot producing area in Demak Regency. The purpose of this research are to know; 1) the attributes characteristics that influenced farmers in choosing shallots planted, 2) The shallot variety that has highest planting frequency, and 3) Comparison of attribute of some shallot varieties that are often planted by farmers in Pasir Village. This research used descriptive method while location sampling has done purposively. The research location are Pasir Village, Mijen District. Sampling of farmers was carried out by purposive sampling, with respondents involved as many as 42 farmers, taken from 2 selected farmer groups, namely Tani Jaya farmer groups as many as 21 and Tani Makmur 21 people. Data analysis uses tabulation and perceived quality methods. The results showed that the shallot characteristics were considered by the farmers namely the age of harvest (0.18) and production yield (0.17). Farmers prefer to cultivated shallot of Bima Brebes varieties (the first planting season). Farmers planted Bima Sawo variety in the second planting season. The total preference level value obtained showed that the TPT of the Bima Curut variety is the most preferred compared to other varieties, with a value of 1.02.
IMPROVING THE VOCABULARY MASTERY THROUGH WORD-CONNECTION GAME
Authors: Tanasy Novalia
Published: January 2020

Many students face difficulties to express their mind, ideas and feelings because lack of vocabulary. This fact makes them loose the point of information and lead them to the thought that English is a difficult subject, till even frustration. This is why every student must master vocabulary, because when they do, it will be easy for them to master the four language skills. This reasearch aimed to find (1) whether the use of Word-Connection game significantly improved the students vocabulary mastery of the first grade students of English Education in Universitas Muslim Maros on academic year 2018/2019, and (2) their attitudes toward the use of this game. Method of this research was experiment with 2 classes as the subjects. It employed 30 numbers of vocabulary test then analyzed by using inferential statistic SPSS program 25.0 and 20 numbers of close-ended questions questionnaire to find out their attitude towards the use of Word-Connection game. Result of the calculation data said that the mean score improved significantly at the experiment group from 3.476 to 8.356, but at the control group only from 3.950 to 4.550. Standard deviation at experiment group decreased from 1.2444 to 0.9238 and at control group from 1.5472 to 1.7604. Range on normalized gain score at the experiment group was 0.37, smaller than control group which was 0.43. Standard deviation on normalized gain score at experiment group was 0.115511 whereas at control group was 0.11075. Furthermore, data which were collected from questionnaire indicated that the students had positive attitude toward the use of Word-Connection game with mean score 82.68. Findings above concludes that the use of Word-Connection game can improve the students vocabulary mastery at the experiment group.
AN INVESTIGATION OF RELATIONSHIP BETWEEN THE TEACHERS’ CREATIVITY AND THE STUDENTS’ MOTIVATION IN LEARNING ENGLISH
Authors: Huriyah Shofiyatul
Published: January 2020

This study was the investigation of relationship between teachers’ creativity and students’ motivation in learning English. The subjects were 112 students of the Eleventh grade of vocational school, OKU. The instrument used for data collection was questionnaire. The data were statistically analyzed by using  SPSS program for percentage, frequency, mean score, standard deviation, t-test and correlation coefficient. The finding from this study indicated that the teachers’ creativity was categorized good level while the result of the students’ motivation in learning  English showed that 73 students got high motivation level with percentage 66.71% and 38 students gained average motivation level with percentage 33.92%. It meant that most of the students had high motivation in learning English. The correlation coefficient was 0.786 and the correlation level of significance was 0.000<0.05. Therefore, there was positive relationship between the teachers’ creativity and the students’ motivation in learning English.
Metaanálisis sobre la efectividad de la realización de ejercicio físico en pacientes con Espondilitis Anquilosante
Authors: Torres Pérez Alba
Published: January 2020

La Espondilitis Anquilosante es una patología inflamatoria, crónica y degenerativa de las articulaciones. Afecta mayormente a la columna vertebral y a la articulación sacroilíaca. El objetivo de este estudio fue analizar la efectividad de la realización de ejercicios aeróbicos en pacientes diagnosticados de Espondilitis Anquilosante. Para ello, se realizó un metaanálisis utilizando 5 estudios que midiesen el efecto de la realización de ejercicio aeróbico en pacientes con esta enfermedad, sumando un total de 257 participantes. Este metaanálisis se llevó a cabo con el programa estadístico Review Manager 5.3 y comparando los índices BASDAI, BASFI y BASMI (escalas de valoración específicas de esta patología). El resultado obtenido fue la mejora de los signos de la enfermedad gracias a la realización de ejercicios resultando significativa en el índice BASDAI, no siendo significativa en los índices BASFI y BASMI. Como conclusión, se aconseja la realización de ejercicios aeróbicos en pacientes diagnosticados de Espondilitis Anquilosante porque mejora el índice BASDAI.
Opinión pública hacia el castigo de los delincuentes: la importancia del delito cometido
Authors: Aizpurúa González Eva , Fernández Molina Esther
Published: January 2020

El estudio de las actitudes punitivas se ha convertido en una de las principales líneas de investigación de la Criminología actual. En este trabajo se analizan las demandas punitivas según los tipos delictivos. Sus principales aportaciones son la utilización de casos concretos y el empleo de una muestra representativa de la población española (n=1000). Los resultados obtenidos muestran cierto descontento con las penas vigentes que genera tensiones entre las sanciones exigidas socialmente y las previstas legalmente. A pesar de ello, los datos evidencian que las demandas rigoristas no son universales, sino que varían considerablemente en función de los delitos.
The effect of foliar fertilization on darkening of tuber flesh of selected potato cultivars
Authors: BIENIA BERNADETTA , SAWICKA BARBARA , KROCHMAL-MARCZAK BARBARA
Published: January 2020

The aim of the study was to determine the effect of foliar fertilizers with the content of macro- and microelements used in the form of chelates on darkening of the tuber flesh of selected potato cultivars. The research was based on a 3-year (2013‒2015) field experiment carried out in Haczów (49°40'N, 21°54'E) on brown, slightly acidic soil. The experiment was based on the method of randomized sub-blocks, where the first order factor was foliar fertilization: Fortis Zn Mn + Fortis Aminotop (A), Fortis B Mo + Ferti Agro (B), Fortis Zn Mn + Fortis B Mo (C) and a standard object without foliar fertilization (0). Second-order factor included four edible potato cultivars of all earliness classes (‘Viviana’, ‘Vineta’, ‘Agnes’, ‘Jelly’). Significant differences in tuber darkening due to foliar application were observed only for tubers 24 h after cooking. The application of Fortis B Mo + Ferti Agro and Fortis Duotop Zn Mn + Fortis Aminotop fertilizers reduced the darkening of the apical part tuber to the greatest extent. Genetic factor differentiated the most the value of all examined traits. The cultivars tested showed varied response to foliar fertilizers.
The Spatial Regulation of Pupils’ Bodies to Train Turkish Nationals in Primary Schools: A Foucauldian Analysis
Authors: Dokuzoglu Ottewell Alca
Published: January 2020

The aim of this research was to explore the use of space and place in natural classroom and the
school environment in a Turkish context. Drawing upon the theoretical framework of Foucault’s
modern power control strategies, a major factor influencing teachers’ classroom practices both in the
State and the Private Primary Schools emerged. A highly centralised Turkish educational system has
a major influence on teachers’ classroom practices. Teachers’ classroom behaviour may be explained
through the spatiality of the schools. Spatiality can also be considered to be a mode of modern power
control. Therefore the structure of space in both the State and the Private Primary Schools is a form
of surveillance apparatus. In particular, Ataturk portraits and Turkish flags were prominently
displayed in every corner of the Primary Schools, which seemed to act as a reminder of the state
control and ‘Turkishness’. Systematic surveillance techniques were employed at the schools.
Comparative Histological Evaluation of the Fruit of Ribes nigrum and Ribes rubrum
Authors: Laczkó-Zöld Eszter , Komlósi Andrea , Varga Erzsébet , Papp Nóra
Published: January 2020

To complete the wide range of studies on chemical composition and pharmacological potential of the fruit of Ribes nigrum and Ribes rubrum, this work aimed to perform a comparative morpho-anatomical characterization of the fruits of both species and complete previously records of black currant as frequently studied species. Microslides of fruits were made with rotation microtome, and then cross sections were stained with toluidine blue. Documentation and evaluation were carried out in microphotos. In R. rubrum, the epidermis cells are ovoid to round, while those of R. nigrum are rectangular to almost round. Under the epidermis, in both fruits, there are two layers of oval hypodermal cells. Underneath the hypodermal layers, parenchyma cells of different size with thin walls and scattered collateral closed bundles were detected. The seeds are embedded in a gelatinous sheath having large thin-walled cells. Endocarp separates the arillar tissue from parenchyma cells, in addition, a gap can be found among these layers, endocarp, arillar tissue, and seeds. The seed coat consists of sclerenchyma cells in both species. In conclusion, histological differences and similarities were described in the fruits of the selected Ribes species, highlighted the first morpho-anatomical description of the berry of Ribes rubrum.
Evaluation of Morphometric Parameters in Case of Leucojum vernum L. from the Peres Forest in Velyka Dobron Wildlife Reserve, Western Ukraine
Authors: Kohut Erzsébet , Kopor Zoltán , Nagy Béla , Csoma Zsuzsanna , Hadnagy István
Published: January 2020

Leucojum vernum L. (Amaryllidaceae) is a bulbous geophyte from Central Europe known as medicinal and ornamental plant. Native population of this species can be found in the Peres Forest (parcels number 23-24) from Velyka Dobron Wildlife Reserve (Western Ukraine), monitored continuously since 2014. The aim of this study was the morphometric evaluation of the species and the chemistry analysis of the soil in which the species grow. According to our results the length of leaf sheath was the most variable parameter from the evaluated morphometric indicators (number of leaves, maximum leaf length and width, bract length, leaf sheath length, scape length, and bulb diameter). Correlations were found between maximum leaf length and scape length, but also between maximum leaf length and bract length. Soil chemistry analysis showed that the chemical properties of the soil are favorable for the studied plants. The soil pH was slightly acidic, the humus content and the supply of alkaline hydrolyzed nitrogen were high, and the amount of soluble P2O5 was moderate. Differences between the territories were found with respect to the soil agrochemical parameters.
Plant Aquaporins
Authors: Curticăpean Manuela-Claudia
Published: January 2020

This mini-review briefly presents the main types of plant aquaporins, highlighting their importance for different plant species and for plant cellular functions. Aquaporins (AQPs), families of water channel proteins (WCPs) are transmembrane proteins that are present in prokaryotes, animals, plants, and humans. The plant aquaporins are part of the Major Intrinsic Proteins (MIPs) family which resides in the following plant organs: roots, stems, leaves, flowers, fruits, and seeds. According to the sub-cellular localization, to their sequence homologies and to their phylogenetic distribution, plant aquaporins have been divided in five subgroups: (a) plasma membrane intrinsic proteins (PIPs); (b) tonoplast intrinsic proteins (TIPs); (c) Nodulin26-like intrinsic membrane proteins (NIPs); (d) small basic intrinsic proteins (SIPs) and (e) uncharacterized intrinsic proteins (XIPs). Different subclasses of the plant aquaporins allow several types of transport using: water, glycerol, urea, hydrogen peroxide, organic acids, ethanol, methanol, arsenite, lactic acid, and gaseous compounds. Plant aquaporins have a significant role in cell response to cold stress, photosynthesis, plant growth, cell elongation, reproduction, and seed germination.
Synthesis of bioactive quinazolin-4(3H)-one derivatives via microwave activation tailored by phase-transfer catalysis
Authors: El-Badry Yaser A. , El-Hashash Mahr A. , Al-Ali Khalil
Published: January 2020

A series of nine new 2,3-disubstituted 4(3H)-quinazolin-4-one derivatives was furnished starting from the 2-propyl-4(3H)-quinazo-line-4-one (2). The reinvestigation of the key starting quinazolinone 2 was performed under microwave irradiation (MW) and solvent-free conditions. Combination of MW and phase-transfer catalysis using tetrabutylammonium benzoate (TBAB) as a novel neutral ionic catalyst was used for carrying out N-alkylation and condensation reactions of compound 2 as a simple, efficient and eco-friendly technique. The structure of the synthesized compounds was elucidated using different spectral and chemical analyses. In vitro antimicrobial activity of the compounds was investigated against four bacterial and two fungal strains; very modest activity was achieved. Some of the synthesized compounds were screened for their antitumor activity against different human tumor cell lines. The screened compounds exhibited a significant antitumor activity on some of the cancer cell lines, melanoma (SK-MEL-2), ovarian cancer (IGROV1), renal cancer (TK-10), prostate cancer (PC-3), breast cancer (MCF7) and colon cancer (HT29). The most active, even more active than the reference 5-fluorouracil, were found to be ethyl 4-[(4-oxo-2-propylquinazolin-3(4H)-yl)methyl]benzoate (3c), 3-{2-[6-(pyrrolidin-1-yl-sulfonyl)-1,2,3,4-tetrahydroquinoline]-2-oxoethyl}-2-propylquinazolin--4(3H)-one (3e), N’-[(E)-(2H-1,3-benzodioxo-5-yl)methylidene]-2-(4-oxo-2-propylquinazolin-3(4H)-yl)acetohydrazide (10a), N’-[(E)-(4-hydroxyphenyl)methylidene]-2-(4-oxo-2-propylquinazo-lin-3(4H) -yl)acetohydrazide (10b) and N’-[(E)-(4-nitrophenyl)methyl idene]-2-(4-oxo-2-propylquinazolin-3(4H)-yl)acetohydrazide (10c).
Biopharmaceutical classification of desloratadine – not all drugs are classified the easy way
Authors: Berginc Katja , Sibinovska Nadica , Žakelj Simon , Trontelj Jurij , Legen Igor
Published: January 2020

The biopharmaceutical classification of drugs was designed as a basis for bio-waivers – a mechanism with the double ethical benefit of delivering new drug formulations to the market with less human testing and lower cost. However, many drugs defy simple classification because in vitro permeability and stability assessment can be challenging as shown in this study for desloratadine. Literature shows that desloratadine is highly soluble, while data on luminal stability and permeability are circumstantial. Combined with borderline bioavailability and not really known fraction of absorbed dose, desloratadine was found to be a good example for showing the innovative in vitro approaches necessary to unambiguously classify desloratadine according to Biopharmaceutical Classification System (BCS) guideline. Presented study undoubtedly confirmed that desloratadine solubility is high and dissolution is very rapid for immediate release reference tablets. We have demonstrated deslorata-dine stability under legally required conditions and also in more physiologically relevant media. High in vitro desloratadine permeability was confirmed using Caco-2 and Parallel Artificial Membrane Permeability Assay (PAMPA). Well-established in vitro model with rat intestinal tissue could not be used due to reasons elaborated in this paper.
SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1
Authors: Zheng Bin , Wang Gang , Gao Wenbo , Wu Qiquan , Zhu Weizhi , Weng Guobin
Published: January 2020

The incidence of mortality of prostate cancer (PCa) has been an uptrend in recent years. Our previous study showed that the sex-determining region Y-box 7 (SOX7) was low-expressed and served as a tumor suppressor in PCa cells. Here, we describe the effects of polyphyllin D (PD) on proliferation and cell cycle modifications of PCa cells, and whether SOX7 participates in this process. PC-3 cells were cultured in complete medium containing PD for 12, 24, and 48 h. MTT assay was used to investigate the cytotoxic effects of PD. Cell cycle progression was analyzed using propidium iodide (PI) staining, and protein levels were assayed by Western blot analysis. Our results showed low expression of SOX7 in PCa tissues/cells compared to their non-tumorous counterparts/RWPE-1 cells. Moreover, PD inhibited the proliferation of PC-3 cells in a dose- and time-dependent manner. PD induced G0/G1 cell cycle arrest, while co-treatment with short interfering RNA targeting SOX7 (siSOX7) had reversed this effect. PD downregulated SOX7, cyclin D1, cyclin-dependent kinase 4 (CDK4), and cyclin-dependent kinase 6 (CDK6) expressions in a dose-dependent manner, whereas co-treatment of siSOX7 and PD rescued the PD-inhibited cyclin D1 expression. However, no obvious changes were observed in CDK4 or CDK6 expression. These results indicate that SOX7 is involved in PD-induced PC-3 cell cycle arrest through down-regulation of cyclin D1.
Maternal education, health profession and cigarette smoking are decisive factors for self-medication in children by parents
Authors: Duborija-Kovacevic Natasa , Martinovic Milica , Belojevic Goran , Lausevic Dragan , Asanin Bogdan
Published: January 2020

Self-medication of children by their parents (SMCP) is an important public health issue as the effects and potential risks may be unpredictable. The objective of this first national Montenegrin study was to assess the prevalence of and factors influencing SMCP among schoolchildren. Data were obtained from a national representative sample of 4496 schoolchildren aged 7–13 years (50.4 % boys). Parents/caregivers completed a questionnaire concerning their demographic characteristics, socio-economic and cultural status, as well as the self-medication (SM) of their children. The association between SMCP and parents’ socio-economic, demographic or cultural status was assessed by logistic regression analyses. The prevalence rate of SMCP was 24.6 %. Univariate logistic regression showed that maternal socio-demographic characteristics (educational level, employment status, health care profession and smoking habits) were relevant for SMCP. In a multiple logistic regression the independent effect /adjusted odds ratio (AOR) (95 % CI)/of maternal factors on SMCP remained for: education /2.23 (1.18–4.24)/, university-level vs. no education; profession /1.50 (1.07–3.00)/, health profession vs. non-health profession; and smoking habit /1.22 (1.04–1.42)/smokers vs. non-smokers. SMCP may be expected for every fourth child in Montenegro. Specific maternal factors that independently raise the probability of SMCP are higher education, health profession and smoking.
Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves
Authors: Onoja Samuel O. , Nnadi Charles O. , Udem Samuel C. , Anaga Aruh O.
Published: January 2020

Heliangolide is a naturally occurring sesquiterpene lactone and its derivatives are biologically active compounds present in most medicinal plants. This study evaluated the antioxidant and antidiabetic properties of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves. The heliangolide sesquiterpene lactone was isolated through a combination of solvent-solvent partitioning, column chromatography, thin layer chromatography and high-performance liquid chromatography techniques. The antioxidant activity of the compound was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide radical scavenging assays while the antidiabetic effects were investigated in alloxan-induced diabetic rats. The heliangolide derivative at the concentration of 954.2 µmol L−1 showed 23.7 % DPPH and 26 % nitric oxide radical inhibitions compared with 96.6 and 50.9 %, resp., displayed by the controls (2,271.2 µmol L−1). It also reduced the fasting blood glucose (FBG) levels in a time-dependent manner. The highest activity was recorded within 6 h post-treatment at 0.2 mmol kg−1 bm. The heliangolide derivative exhibited significant (p < 0.05) antioxidant and antidiabetic properties and provides a basis for further development of constituents of Helianthus annuus leaves for the management of such diseases.
Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells
Authors: Ihraiz Worood G. , Ahram Mamoun , Bardaweel Sanaa K.
Published: January 2020

Breast cancer is the most common cancer and is the leading cause of cancer deaths among women worldwide. Despite the availability of numerous therapeutics for breast cancer management, cytotoxicity and emergence of drug resistance are major challenges that limit their benefits. The acidic microenvironment surrounding tumor cells is a common feature inducing cancer cell invasiveness and chemoresistance. Proton pump inhibitors (PPIs) are one of the most commonly prescribed drugs for the treatment of acid-related conditions. PPIs have been reported to exhibit antitumorigenic effects in many cancer types. In this study, the anti-proliferative and anti-migratory effects of PPIs in three breast cancer cell lines; MCF-7, T47D, and MDA-MB-231 cells, have been investigated. In addition, the combined effects of PPIs with anticancer drugs, as well as the mechanism of PPI-mediated anti-proliferative activity were evaluated. The anti-proliferative and combined effects of PPIs were evaluated by MTT assay. Cell migration was assessed using the wound-healing assay. The mechanism of cell death was assessed using annexin V-FITC/propidium iodide staining flow cytometry method. Our results indicated that PPIs treatment significantly inhibited the growth of breast cancer cells in a dose-dependent manner. The antiproliferative activity of PPIs was significantly induced by apoptosis in all tested cell lines. The combined treatment of PPIs with doxorubicin resulted in a synergistic effect in all cell lines, whereas the combined treatment with raloxifene exhibited synergistic effect in T47D cells only and additive effects in MDA-MB-231 and MCF-7 cells. In addition, PPIs treatment significantly reduced cell migration in MDA-MB-231 cells. In conclusion, the addition of PPIs to the treatment regimen of breast cancer appears to be a promising strategy to potentiate the efficacy of chemotherapy and may suppress cancer metastasis.
Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors
Authors: Zaher Nashwa Hafez , Mostafa Mohammed Ismail , Altaher Abdullah Yousef
Published: January 2020

Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries. Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay. All new compounds underwent justification for their target structures via microanalytical and spectral data. SAR studies were performed. Biological results revealed that the most potent compounds were 4-(cyclopent-1-en-3-ylamino)-5-(2-(4-iodophenyl)hydrazinyl)-4H-1,2,4-triazole-3-thiol (16) and 4-(cyclopent-1-en-3-ylamino)-5-[2-(4-chlorophenyl)hydrazinyl]-4H-1,2,4-triazole-3-thiol (12). In silico molecular docking of the most potent compounds was performed to the active binding site of MERS-CoV helicase nsp13. Molecular docking results are in agreement with experimental findings.
Atmospheric Plasma Spraying of Al2O3 + 13% TiO2 Coatings Using External and Internal Injection System
Authors: Łatka L. , Michalak M. , Jonda E.
Published: January 2020

The ceramic coatings based on mixture of Al2O3 and TiO2 have better properties in comparison to the pure alumina ones. Among many techniques, plasma spraying is very useful method of ceramic coatings manufacturing. In this paper, the results of microscopic, mechanical and tribological properties investigations of Al2O3 + 13 wt% TiO2 coatings manufactured by atmospheric plasma spraying are presented. The cylinder substrates made from stainless steel (X5CrNi18-10) had a diameter equal to 25 mm and thickness equal to 2 mm. The plasma spray experimental parameters included three variables: (i) type of injection system (external or internal), (ii) size of corundum particles for sandblasting and (iii) torch linear speed. The results confirm, that type of injection system is a dominant parameter. Internal injection results in better degree of particles melting, what influences on wear resistance performance, as well as higher values of bond strength.
Effect of Slide Burnishing on the Surface Layer and Fatigue Life of Titanium Alloy Parts
Authors: Zaleski K. , Skoczylas A.
Published: January 2020

The paper presents the results of a study investigating the effect of slide burnishing on the surface roughness, surface layer microhardness and fatigue life of Ti6Al2Mo2Cr titanium alloy parts. The burnishing process was performed with the use of a diamond tip tool. Different machining fluids were used as machining media. Prior to burnishing, the samples were subjected to turning. The burnishing process led to reduced surface roughness (average roughness Ra decreased by 3.5 times and roughness Rz decreased by 2.5 times) as well as increased surface layer microhardness (microhardness maximum increase by 12%) and fatigue life of the tested parts. A relationship between the machining medium and the burnishing effects was also observed. The addition of a surface-active polymethyl methacrylate solution to the machining medium led to an increase in the surface layer microhardness and fatigue life of the workpiece.
Effect of Storage Conditions of Rutile Flux Cored Welding Wires on Properties of Welds
Authors: Świerczyńska A.
Published: January 2020

The influence of storage locations of two grades of rutile flux cored welding wires on their surface condition and the strength of the welds made with them were studied. Wires were stored in real urban conditions (Gdańsk and Katowice) for 1 month, simultaneously recording changes in conditions: temperature and relative humidity of the environment. Visual tests of wires in the delivered and stored condition as well as visual and tensile strength tests of welds made with them were carried out. It was found that the surface of the wires underwent more intense degradation (atmospheric corrosion) during storage in Katowice than in Gdańsk. Significant difference in tensile strength was observed only for padding welds made using Gdańsk stored wires. The lowest recorded tensile strength value was not lower than the standard requirements for the wires.
Application of the 3D Digital Image Correlation to the Analysis of Deformation of Joints Welded With the FSW Method After Shot Peening
Authors: Kubit A. , Bucior M. , Kluz R. , Święch Ł. , Ochał K.
Published: January 2020

The three dimensional Digital Image Correlation (3D DIC) method is used for measurements of deformations and displacement in plane elements exposed to loading. The paper presents the experimental tests of an application of the ARAMIS system to the analysis of deformation of joints welded with the FSW method after shot peening treatment. The butt joints were made of 2024-T3 aluminum alloy sheets with the thickness of 1 mm, which next were peened with glass beads about granulation in range 500 ÷ 900 µm. Tests of residual stresses by X-ray diffraction were also carried out. The aim of the study was to analyze the impact of shot peening on the value of stresses and the location of deformations in butt joints.