bluuebunny/crossref_metadata_2025 huggingface dataset:
Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cells
Authors: Wang M‐H , Lee W , Luo Y‐L , Weis MT , Yao H‐P
Published: October 2007

Aberrant expression of the RON receptor tyrosine kinase has been implicated in the pathogenesis of epithelial tumours. The aim of this study was to determine RON expression in various normal epithelial cells and their corresponding tumours by immunohistochemistry. The role of RON in regulating tumourigenic phenotypes was also studied using thyroid cancer cells as a model. RON was almost exclusively expressed at variable levels in normal epithelial cells from the digestive track, lung, kidney, pancreas, liver, breast, bladder, skin, and others. Among 15 types of cancer studied, RON was overexpressed in significant numbers in cancers derived from breast (56%), colon (51%), lung (48), thyroid (42%), skin (37%), bladder (36%), and pancreas (33%). In contrast, limited RON overexpression was observed in cancers from stomach, kidney, brain, liver, ovary, and prostate. Detailed analysis of thyroid tissues showed that RON was hardly detected in normal thyroid cells, moderately expressed in adenoma samples, but overexpressed in about half of papillary and follicular cancer specimens. Overexpression correlated with advanced clinical stage and was associated with lymph node metastasis. In cultured thyroid cancer cells, RON was highly expressed, with constitutive phosphorylation. Activation of RON increased cell growth and migration via the MAP kinase and AKT pathways. Silencing RON expression significantly prevented cell growth and increased cell apoptotic death. These findings show that RON overexpression occurs in a particular group of epithelial cancers. The requirement for RON in sustaining tumourigenic phenotypes suggests that it is a potential target for therapeutic intervention. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Early detection of adverse drug events within population‐based health networks: application of sequential testing methods
Authors: Brown Jeffrey S. , Kulldorff Martin , Chan K. Arnold , Davis Robert L. , Graham David , Pettus Parker T. , Andrade Susan E. , Raebel Marsha A. , Herrinton Lisa , Roblin Douglas , Boudreau Denise , Smith David , Gurwitz Jerry H. , Gunter Margaret J. , Platt Richard
Published: October 2007

Purpose

Active surveillance of population‐based health networks may improve the timeliness of detection of adverse drug events (ADEs). Active monitoring requires sequential analysis methods. Our objectives were to (1) evaluate the utility of automated healthcare claims data for near real‐time drug adverse event surveillance and (2) identify key methodological issues related to the use of healthcare claims data for real‐time drug safety surveillance.

Methods

We assessed the ability to detect ADEs using historical data from nine health plans involved in the HMO Research Network's Center for Education and Research on Therapeutics (CERT). Analyses were performed using a maximized sequential probability ratio test (maxSPRT). Five drug‐event pairs representing known associations with an ADE and two pairs representing ‘negative controls’ were analyzed.

Results

Statistically significant (p < 0.05) signals of excess risk were found in four of the five drug‐event pairs representing known associations; no signals were found for the negative controls. Signals were detected between 13 and 39 months after the start of surveillance. There was substantial variation in the number of exposed and expected events at signal detection.

Conclusions

Prospective, periodic evaluation of routinely collected data can provide population‐based estimates of medication‐related adverse event rates to support routine, timely post‐marketing surveillance for selected ADEs. Copyright © 2007 John Wiley & Sons, Ltd.
Study of the use of a spironolactone and angiotensin‐converting enzyme inhibitor combination: a population‐based analysis
Authors: Besançon Jean‐François , Lagarce Laurence , Diquet Bertrand , Lainé‐Cessac Pascale
Published: October 2007

Purpose

To analyse the conditions of use of the drug combination in outpatients.

Methodology

The first section consisted of a population‐based analysis using computerized records from the French national health insurance system. The study population consisted of adult patients, receiving long‐term treatment with spironolactone (SPIR) and angiotensin‐converting enzyme inhibitor (ACEI). For each patient, the reimbursement of serum potassium and creatinine determinations was searched for in the database during the 6‐month period preceding the date of the last dispensation. The second section comprised a written questionnaire on use practises, sent to practitioners who prescribed the drug combination to randomly selected patients. Analysis of the answers to the questionnaire made it necessary to develop a reference system. In the third section, procedure one was repeated at a later stage, following an information campaign, in order to measure its impact.

Results

The exhaustive population under procedure 1 consisted of 3620 patients (71 ± 11 years). During the 6 months prior to the index date, 51% of patients underwent at least one determination of both serum potassium and serum creatinine. The randomised population under procedure two consisted of 441 patients (70 ± 13 years) and their 375 practitioners. When compared with the reference system, SPIR–ACEI was used for the recommended indications, at the appropriate SPIR–ACEI dosages, and under minimal monitoring of biological parameters in only 65 patients (15%). After the information campaign, results were disappointing because only 55% of patients underwent the minimal laboratory monitoring.

Conclusion

The use of the drug combination in general practice was mainly inappropriate. Copyright © 2007 John Wiley & Sons, Ltd.
Synthesis of well‐defined dendritic hyperbranched polymers by iterative methodologies using living/controlled polymerizations
Authors: Hirao Akira , Sugiyama Kenji , Matsuo Akira , Tsunoda Yuji , Watanabe Takumi
Published: October 2007

This review presents firstly the synthesis of various dendritic hyperbranched polymers with well‐defined structures by generation‐based growth methodologies using living/controlled polymerization. Secondly, the synthesis of dendritic hyperbranched poly(methyl methacrylate)s (PMMAs) and their functionalized block copolymers using a novel iterative methodology is described. The methodology involves a two‐reaction sequence in each iterative process: (a) a linking reaction of α‐functionalized living anionic PMMA with tert‐butyldimethylsilyloxymethylphenyl (SMP) groups with benzyl bromide (BnBr)‐chain‐end‐functionalized polymer and (b) a transformation reaction of the SMP groups into BnBr functions. This reaction sequence is repeated several times to construct high‐generation (maximum seventh generation) dendritic hyperbranched polymers. Similar branched architectural block copolymers have also been synthesized by the same iterative methodology using other α‐functionalized living anionic polymers. Surface structures of the resulting dendritic hyperbranched block copolymers composed of PMMA and poly(2‐(perfluorobutyl)ethyl methacrylate) segments have been characterized using X‐ray photoelectron spectroscopy and contact angle measurements. Solution behaviors of dendritic hyperbranched PMMAs with different generations and branch densities are discussed based on their intrinsic viscosities, g′ values and Rh values. Copyright © 2007 Society of Chemical Industry
Synthesis and characterization of novel poly(amide urea)s, materials with outstanding mechanical properties
Authors: San‐José Noelia , Gómez‐Valdemoro Ana , García Félix Clemente , de la Peña José Luis , Serna Felipe , García José Miguel
Published: October 2007

Four novel A‐B condensation monomers containing an amine and a carboxylic acid function are described, along with their polymerization to give main chain aromatic poly(amide urea)s. The monomers, and the polymer structural unit, are N,N′‐diphenylurea derivatives. When comparing wholly aromatic polyamides, or aramids, with the poly(amide urea)s described herein, we find that the chemical resistance to hydrolysis of the later polymers increases and their thermal resistance is diminished due to the main chain urea groups, whereas their water uptake is not greatly modified. The most striking result of the new poly(amide urea)s is their outstanding mechanical resistance: their Young's modulus rises as high as 5.5 GPa and their tensile strengths as high as 170 MPa for unoriented films prepared at laboratory scale by casting. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5398–5407, 2007
Novel thermosets obtained by UV‐induced cationic copolymerization of DGEBA with an spirobislactone
Authors: Fernández‐Francos Xavier , Salla Josep M. , Cadenato Ana , Morancho Josep M. , Mantecón Ana , Serra Angels , Ramis Xavier
Published: October 2007

The photocuring process of the diglycidyl ether of bisphenol A (DGEBA) with the bislactone 1,6‐dioxaspiro[4,4]nonane‐2,7‐dione (s(γ‐BL)) was studied. Triarylsulfonium hexafluoroantimonate was employed as photoinitiator. FTIR/ATR was used to study the evolution of epoxy, lactone, and intermediate spiroorthoester groups to identify the different reactions that take place during the photocuring process. Photo‐DSC and DSC were used to study the thermal evolution of the photocuring process and to assess the Tg of the fully cured material. Thermogravimetric analysis (TGA) was used to determine the thermal stability of the fully cured material. The thermomechanical properties of the materials were investigated using dynamic mechanical‐thermal analysis. Shrinkage undergone during photocuring and gelation was studied with TMA. A strong influence of the photocuring temperature on the photocuring process of the DGEBA‐ s(γ‐BL) system was observed. Differences in the reactivity of the different species were observed with respect to the thermally cured system using ytterbium triflate as cationic thermal initiator. As a consequence, photocured materials exhibited a superior thermal stability and lower flexibility. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5446–5458, 2007
Dual effects of fullerene doped to holographic polymer dispersed liquid crystals
Authors: Woo Ju Yeon , Kim Eun Hee , Kim Byung Kyu
Published: October 2007

Doping of conductive fullerene particles to the formulation of conventional holographic polymer dispersed liquid crystal‐induced dual effects of reducing both droplet coalescence and operating voltage. Fullerene induced an induction period which otherwise does not exist, followed by a gradual increase of diffraction efficiency to a saturation value being increased with increasing fullerene content. The increased diffraction efficiency was caused by the decreased droplet coalescence which was due to the hindered migration of LC by the fullerene particles. On the other hand, doped fullerene particles augmented the conductivity of polymer phase and hence the local electrical field imposed on LC droplet, which overcome the threshold for driving and reduced operating voltage and response times. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5590–5596, 2007
Synthesis of highly reactive polyisobutylenes using solvent‐ligated manganese(II) complexes as catalysts
Authors: Radhakrishnan Narayanan , Hijazi Ahmed K. , Komber Hartmut , Voit Brigitte , Zschoche Stefan , Kühn Fritz E. , Nuyken Oskar , Walter Michael , Hanefeld Phillip
Published: October 2007

Manganese complexes with benzonitrile ligands were synthesized, characterized, and applied for the preparation of the isobutylene polymerization. Low and medium molecular weight polyisobutylenes containing high amount of exo‐type double bond end groups (70–80%) were successfully prepared using these manganese(II) complexes as catalysts at room temperature. The influence of monomer and catalyst concentration was intensively analyzed for achieving high monomer conversion and high exo double bond content of the products. Details on end group distribution in the products and development of the exo‐type end group content with reaction time were evaluated by 1H NMR. The catalysts are also active for the homopolymerization of styrene and the copolymerization of isobutylene and styrene. The highly reactive polyisobutylene products obtained by these manganese complexes show features similar to products obtained by conventional cationic polymerization, but the polymerization characteristics clearly deviate. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5636–5648, 2007
One‐shot synthesis of high molar mass polyurethane in supercritical carbon dioxide
Authors: Renault Benjamin , Tassaing Thierry , Cloutet Eric , Cramail Henri
Published: October 2007

Well‐defined polyurethane–polydimethylsiloxane particles of tunable diameter in the range of 0.5–20 μm were synthesized in “one‐shot” by step‐growth polymerization using supercritical carbon dioxide (scCO2) as a dispersant medium. Polymerizations were carried out at 60 °C and above 25 MPa, after the solubility of each reactant in scCO2 has been determined in its typical reaction concentration. The synthesis of such copolymers was achieved by polyaddition between short aliphatic diols, that is, ethylene glycol, 1,4‐butanediol (BD) or polyethylene oxide (Mn = 200 g mol−1), and tolylene‐1,4‐di‐isocyanate (TDI) in the presence of mono or di‐isocyanate‐terminated polydimethylsiloxane (PDMS) as reactive stabilizers and dibutyltin dilaurate as a catalyst. The nature of the diol used as well as the functionality of the reactive stabilizer incorporated was found to have a dramatic effect on the molar mass and the morphology of the resulting product. Thus, copolymers obtained from the polyaddition of BD and TDI in the presence of di‐isocyanate‐terminated PDMS exhibit molar mass up to 90,000 g mol−1. Thermal behaviors of copolymers were also examined by differential scanning calorimetry. All samples exhibited only one glass transition temperature (Tg) and were found to be totally amorphous. A logical decrease of the Tg was observed as the length of the diol incorporated increased, that is, as the density of urethane linkages within the polymer decreased. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5649–5661, 2007
Yttrium bis(alkyl) and bis(amido) complexes bearing N,O multidentate ligands. Synthesis and catalytic activity towards ring‐opening polymerization of L‐lactide
Authors: Shang Xiaomin , Liu Xinli , Cui Dongmei
Published: October 2007

Methoxy‐modified β‐diimines HL1 and HL2 reacted with Y(CH2SiMe3)3(THF)2 to afford the corresponding bis(alkyl)s [L1Y(CH2SiMe3)2] (1) and [L2Y(CH2SiMe3)2] (2), respectively. Amination of 1 with 2,6‐diisopropyl aniline gave the bis(amido) counterpart [L1Y{N(H)(2,6‐iPr2C6H3)}2] (3), selectively. Treatment of Y(CH2SiMe3)3(THF)2 with methoxy‐modified anilido imine HL3 yielded bis(alkyl) complex [L3Y(CH2SiMe3)2(THF)] (4) that sequentially reacted with 2,6‐diisopropyl aniline to give the bis(amido) analogue [L3Y{N(H)(2,6‐iPr2C6H3)}2] (5). Complex 2 was “base‐free” monomer, in which the tetradentate β‐diiminato ligand was meridional with the two alkyl species locating above and below it, generating tetragonal bipyramidal core about the metal center. Complex 3 was asymmetric monomer containing trigonal bipyramidal core with trans‐arrangement of the amido ligands. In contrast, the two cis‐located alkyl species in complex 4 were endo and exo towards the O,N,N tridentate anilido‐imido moiety. The bis(amido) complex 5 was confirmed to be structural analogue to 4 albeit without THF coordination. All these yttrium complexes are highly active initiators for the ring‐opening polymerization of L‐LA at room temperature. The catalytic activity of the complexes and their “single‐site” or “double‐site” behavior depend on the ligand framework and the geometry of the alkyl (amido) species in the corresponding complexes. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5662–5672, 2007
Polymer‐supported pyridinium catalysts for synthesis of cyclic carbonate by reaction of carbon dioxide and oxirane
Authors: Ochiai Bungo , Endo Takeshi
Published: October 2007

Polymer‐supported pyridinium salts, prepared by quaternarization of crosslinked poly(4‐vinylpyridine) with alkyl halides, effectively catalyze the reaction of carbon dioxide (1 atm) and glycidyl phenyl ether (GPE) to afford the corresponding five‐membered cyclic carbonate (4‐phenoxymethyl‐1,3‐dioxolan‐2‐one). Poly(4‐vinylpyridine) quarternarized with alkyl bromides show high catalytic activities, and the reaction of carbon dioxide (1 atm) and GPE at 100 °C affords 4‐phenoxymethyl‐1,3‐dioxolan‐2‐one quantitatively in 6 h. The rate constant in the reaction of GPE and carbon dioxide in N‐methyl pyrrolidinone using poly(4‐vinylpyridine) quarternarized with n‐butyl bromide (kobs = 102 min−1) is almost comparable with those for homogeneous catalysts with good activities (e.g., LiI), and the rate of the reaction obeys the first‐order kinetics. A used catalyst may be recovered by centrifugation, and the recycled catalyst also promotes the reaction of GPE and carbon dioxide. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5673–5678, 2007
Bioorthogonal Click Chemistry: Covalent Labeling in Living Systems
Authors: Baskin Jeremy M. , Bertozzi Carolyn R.
Published: October 2007

The term “click chemistry” defines a powerful set of chemical reactions that are rapid, selective, and high‐yielding. These reactions, some of which are less than 10 years old, have been applied in diverse areas, including drug discovery, materials science, and chemical biology. In chemical biology, click chemistry has been used in the selective labeling of biomolecules within living systems, allowing proteins, glycans, and other important biomolecules to be monitored in a physiologically relevant environment rather than in an in vitro setting. This demanding application requires not only the aforementioned characteristics of click chemistry but, additionally, that the reactions are bioorthogonal – that is, non‐interacting with biological functionality while proceeding under physiological conditions – and that the reagents are non‐toxic. Of the many extant click reactions, only a select few possess this unique combination of attributes, notably the Staudinger ligation of azides and triarylphosphines and [3+2] dipolar cycloadditions of azides with strained alkynes. This minireview describes the characteristics of bioorthogonal click reactions as well as recent applications toward labeling biomolecules in cells and living organisms.
Synthesis of Ring‐Expanded Aza‐Analogues of Bisbenzocyclooctadiene Lignan Lactones
Authors: Donets Pavel A. , Van der Eycken Erik V.
Published: October 2007

We report a novel microwave‐assisted protocol for the synthesis of hitherto unknown 11‐membered ring lignan lactone aza‐analogues. The two key steps involve the formation of the biaryl fragment using a microwave‐assisted Suzuki‐Miyaura cross‐coupling reaction and a thermal 1,3‐dipolar Huisgen cycloaddition reaction for the introduction of the 1,2,3‐triazole ring rendering the cyclized compound.
Robotic surgery for gastrointestinal malignancies
Authors: Anderson C. , Hellan M. , Kernstine K. , Ellenhorn J. , Lai L. , Trisal V. , Pigazzi A
Published: October 2007

Background

This report describes our initial experience with the use of robotic‐assisted surgery for the treatment of gastrointestinal (GI) malignancies.

Methods

Between November 2004 and July 2007, 73 robotic procedures (26 female, 47 male) for GI cancer were performed and retrospectively reviewed. Procedures included 25 oesophagectomies, 11 gastrectomies and 37 rectal resections. The median body mass index (BMI) for this patient population was 26.

Results

The median operative times for rectal, oesophageal and gastric resections were 285, 482 and 430 min, respectively. There were three conversions. Major postoperative morbidity was 16% for rectal, 32% for oesophageal and 9% for gastric procedures. The leak rate was 11% for rectal, 16% for oesophageal and 9% for gastric anastomoses. Median length of stay was 4, 11 and 5 days, respectively. The median number of lymph nodes harvested was 13, 22, and 26 for rectal, oesophageal and gastric lymphadenectomies, respectively. At a median follow‐up of 9 months, one patient developed a port site recurrence; 30 day mortality was zero.

Conclusion

This initial experience suggests that the robotic approach is safe and feasible for a variety of radical oncological surgical procedures. Copyright © 2007 John Wiley & Sons, Ltd.
Improving robot arm control for safe and robust haptic cooperation in orthopaedic procedures
Authors: Cruces R. A. Castillo , Wahrburg J.
Published: October 2007

Background

This paper presents the ongoing results of an effort to achieve the integration of a navigated cooperative robotic arm into computer‐assisted orthopaedic surgery. A seamless integration requires the system acting in direct cooperation with the surgeon instead of replacing him.

Methods

Two technical issues are discussed to improve the haptic operating modes for interactive robot guidance. The concept of virtual fixtures is used to restrict the range of motion of the robot according to pre‐operatively defined constraints, and methodologies to assure a robust and accurate motion through singular arm configurations are investigated.

Results

A new method for handling singularities is proposed, which is superior to the commonly used damped‐least‐squares method. It produces no deviations of the end‐effector in relation to the virtually constrained path.

Conclusions

A solution to assure a good performance of a hands‐on robotic arm at singularity configurations is proposed. Copyright © 2007 John Wiley & Sons, Ltd.
A mechanistic latent variable model for estimating drug concentrations in the male genital tract: A case study in drug kinetics
Authors: Choi Leena , Caffo Brian , Rohde Charles , Ndovi Themba T. , Hendrix Craig W.
Published: October 2007

The purpose of this study is to develop statistical methodology to facilitate indirect estimation of the concentration of antiretroviral drugs and viral loads in the prostate gland and the seminal vesicle. The differences in antiretroviral drug concentrations in these organs may lead to suboptimal concentrations in one gland. Suboptimal levels of the antiretroviral drugs may not be able to fully suppress the virus in that gland, leading to a source of sexually transmissible virus and increasing the chance of selecting for a drug‐resistant virus. This information may be useful for selecting an antiretroviral drug regimen that will achieve optimal concentrations in the genital tract glands. Using fractionally collected semen ejaculates, Lundquist (Acta Physiol. Scand. 1949; 19:1–95) measured levels of surrogate markers in each fraction that are uniquely produced by specific male accessory glands. To determine the original glandular concentrations of the surrogate markers, Lundquist solved a simultaneous series of linear equations. This method has several limitations. In particular, it does not yield a unique solution, it does not address measurement error, and it does not provide population‐averaged estimates after taking into account inter‐subject variability in the parameters. To cope with these limitations, we developed a mechanistic latent variable model based on the physiology of the male genital tract and surrogate markers. We employ a Bayesian approach and perform a sensitivity analysis on the distributional assumptions on the random effects and priors. The model and Bayesian approach are validated on experimental data where the concentration of a drug should be (biologically) differentially distributed between the two glands. In this example, the Bayesian model‐based conclusions are found to be robust to model specification and this hierarchical approach leads to more scientifically valid conclusions than the original methodology. In particular, unlike existing methods, the proposed model‐based approach was not affected by a common form of outliers. Copyright © 2007 John Wiley & Sons, Ltd.
Managing international strategic alliance relationships
Authors: Wahyuni Sari , Ghauri Pervez , Karsten Luchien
Published: October 2007

The objective of this study is to investigate the development of international strategic alliances (ISAs) and to identify the important factors for each phase of an alliance relationship. We have developed a framework about the process development of alliances that is based on an extensive literature study. The framework is used to study and analyze three cases of ISAs. The findings and conclusions are presented in a manner that can help managers to recognize the stages they have to go through and, more important, to be aware of the determinant variables in each stage of an alliance life cycle. This study found that the continuity of an alliance relationship is highly dependent on how partners manage their operational phase. © 2007 Wiley Periodicals, Inc.
Hypertension after renal transplantation
Authors: Seeman Tomáš
Published: October 2007

Hypertension is a common and serious complication after renal transplantation. It is an important risk factor for graft loss and morbidity and mortality of transplanted children. The etiology of posttransplant hypertension is multifactorial: native kidneys, immunosuppressive therapy, renal-graft artery stenosis, and chronic allograft nephropathy are the most common causes. Blood pressure (BP) in transplanted children should be measured not only by casual BP (CBP) measurement but also regularly by ambulatory BP monitoring (ABPM). The prevalence of posttransplant hypertension ranges between 60% and 90% depending on the method of BP measurement and definition. Left ventricular hypertrophy is a frequent type of end-organ damage in hypertensive children after transplantation (50–80%). All classes of antihypertensive drugs can be used in the treatment of posttransplant hypertension. Hypertension control in transplanted children is poor; only 20–50% of treated children reach normal BP. The reason for this poor control seems to be inadequate antihypertensive therapy, which can be improved by increasing the number of antihypertensive drugs. Improved hypertension control leads to improved long-term graft and patient survival in adults. In children, there is a great potential for antihypertensive treatment that could also result in improved graft and patient survival.
Dentinogenesis imperfecta
Authors: Schulte J.M. , van Waes H.
Published: October 2007

Unter Dentinogenesis imperfecta versteht man eine kongenitale Dysplasie des Dentins, die isoliert oder im Zusammenhang mit einer hereditären Allgemeinerkrankung wie der Osteogenesis imperfecta auftreten kann. Sie wird meist autosomal dominant vererbt und manifestiert sich klinisch in einer opaleszierenden Goldbraun- oder Graublauverfärbung der Zähne beider Dentitionen in variabler Ausprägung. Die verschiedenen Varianten der Dentinogenesis imperfecta werden nach Shields et al. (1973) in 3 Gruppen eingeteilt: Typ I, assoziiert mit Osteogenesis imperfecta; Typ II, hereditär opaleszierendes Dentin; Typ III, Brandywine-Typ. Die Phänotypen der Dentinogenesis imperfecta werden in dem vorliegenden Beitrag hinsichtlich Gendefekt, klinischer Symptomatik, Radiologie und Histopathologie beschrieben, die zahnärztliche Behandlungsstrategie wird dargestellt.
Zahnanomalien in der Neuropädiatrie
Authors: Wolf N.
Published: October 2007

Zahnanomalien in der Neuropädatrie sind einfach zu diagnostizieren und helfen bei der Diagnose verschiedener Erkrankungen. Sie finden sich bei gut bekannten Krankheitsbildern wie der Incontinentia pigmenti, aber auch bei seltenen wie dem Kohlschütter-Tönz-Syndrom oder dem kürzlich beschriebenen Krankheitsbild der Ataxie, verzögerten Dentition und Hypomyelinisierung. Anomalien von Zahnform, Zahnschmelz und damit Zahnfarbe, Zahnanzahl und Eruption sind möglich. Die Kenntnis dieser Auffälligkeiten ist wichtig für den Genetiker und den Kinderneurologen.
Effects of a comprehensive fruit- and vegetable-promoting school-based intervention in three European countries: the Pro Children Study
Authors: te Velde S. J. , Brug J. , Wind M. , Hildonen C. , Bjelland M. , Pérez-Rodrigo C. , Klepp K.-I.
Published: October 2007

The objective of the present study was to evaluate the effects of the Pro Children intervention on schoolchildren's fruit and vegetable (FV) intake after 1 and 2 years of follow-up. The intervention combined a FV curriculum with efforts to improve FV availability at schools and at home. Effects were examined in a group-randomised trial among 1472 10–11-year-old children from sixty-two schools in Norway, the Netherlands and Spain. FV intake was assessed by means of validated self-administered questionnaires completed before the intervention (September 2003), immediately after the first year of the intervention (May 2004) and 1 year later (May 2005). Data were analysed using multilevel linear regression analyses with age and sex as covariates. Significant intervention effects for FV intake were found at first follow-up in the total sample. The adjusted FV intake reported by the children from intervention schools was 20 % higher than FV intake reported by children from control schools. At 1 year later, a significant impact was only observed in Norway. Positive intervention effects on FV intake occurred both at school and outside school. We conclude that the Pro Children intervention is a promising means to promote European schoolchildren's FV intakes, but mainly fruit intake, in the short term. As shown in Norway, where the intervention was best implemented, the intervention might also result in longer-term effects. Further strategies need to be developed that can improve implementation, have an impact on vegetable intake and can secure sustained effects.
Effects of retro-nasal aroma release on satiation
Authors: Ruijschop Rianne M. A. J. , Boelrijk Alexandra E. M. , A. de Ru Jacob , de Graaf Cees , Westerterp-Plantenga Margriet S.
Published: October 2007

It is suggested that the brain response of a food odour sensed retro-nasally is related to satiation. The extent of retro-nasal aroma release during consumption depends on the physical structure of a food, i.e. solid foods generate a longer, more pronounced retro-nasal aroma release than liquid foods. The aim of this study was to investigate if a beverage becomes more satiating when the retro-nasal aroma release profile coincides with the profile of a (soft) solid food. In a double-blind placebo-controlled randomised cross-over full factorial design, twenty-seven healthy subjects (fourteen males and thirteen females; aged 16–65 years; BMI 19–37 kg/m(2) were administered aroma profiles by a computer-controlled stimulator based on air dilution olfactometry. Profile A consisted of a profile that is obtained during consumption of normal beverages. Profile B is normally observed during consumption of (soft) solids. The two profiles were produced with strawberry aroma and administered in a retro-nasal fashion, while the subjects consumed a sweetened milk drink. Before, during and after the sensory stimulation, appetite profile measurements were performed. Subjects felt significantly more satiated if they were aroma stimulated with profile B (P = 0·04). After stimulation with sweet strawberry aroma, there was a significant decrease in desire to eat sweet products (P = 0·0001). In conclusion, perceived satiation was increased by altering the extent of retro-nasal aroma release.
Identification and reproducibility of dietary patterns in a Danish cohort: the Inter99 study
Authors: Lau Cathrine , Glümer Charlotte , Toft Ulla , Tetens Inge , Carstensen Bendix , Jørgensen Torben , Borch-Johnsen Knut
Published: October 2007

We aimed to identify dietary patterns in a Danish adult population and assess the reproducibility of the dietary patterns identified. Baseline data of 3372 women and 3191 men (30–60 years old) from the population-based survey Inter99 was used. Food intake, assessed by a FFQ, was aggregated into thirty-four separate food groups. Dietary patterns were identified by principal component analysis. Confirmatory factor analysis and Bland Altman plots were used to assess the reproducibility of the dietary patterns identified. The Bland Altman plots were used as an alternative and new method. Two factors were retained for both women and men, which accounted for 15·1–17·4 % of the total variation. The ‘Traditional’ pattern was characterised by high loadings ( ≥ 0·40) on paté or high-fat meat for sandwiches, mayonnaise salads, red meat, potatoes, butter and lard, low-fat fish, low-fat meat for sandwiches, and sauces. The ‘Modern’ pattern was characterised by high loadings on vegetables, fruit, mixed vegetable dishes, vegetable oil and vinegar dressing, poultry, and pasta, rice and wheat kernels. Small differences were observed between patterns identified for women and men. The root mean square error approximation from the confirmatory factor analysis was 0·08. The variation observed from the Bland Altman plots of factors from explorativev. confirmative analyses and explorative analyses from two sub-samples was between 18·8 and 47·7 %. Pearson's correlation was >0·89 (P < 0·0001). The reproducibility was better for women than for men. We conclude that the ‘Traditional’ and ‘Modern’ dietary patterns identified were reproducible.
INEQUALITY IN THE AMERICAN SOUTH: EVIDENCE FROM THE NINETEENTH CENTURY MISSOURI STATE PRISON
Authors: CARSON SCOTT ALAN
Published: October 2007

The use of height data to measure living standards is now a well-established method in economic history. Moreover, a number of core findings in the literature are widely agreed upon. There are still some populations, places and times, however, for which anthropometric evidence remains thin. One example is 19th century African-Americans in US border-states. This paper introduces a new data set from the Missouri state prison to track the heights of comparable black and white men born between 1820 and 1904. Modern blacks and whites come to comparable terminal statures when brought to maturity under optimal conditions; however, whites were persistently taller than blacks in the Missouri prison sample by two centimetres. Throughout the 19th century, black and white adult statures remained approximately constant, while black youth stature increased during the antebellum period.
Fusion of functions: The syntax ofonce,twiceandthrice
Authors: PAYNE JOHN , HUDDLESTON RODNEY , PULLUM GEOFFREY K.
Published: October 2007

In this paper we present a detailed new analysis of the English expressionsonce,twiceandthrice. These, we claim, are primarily compound determinatives, analogous in many respects to expressions likesomeoneandsomewhere. The new analysis exploits the framework of theCambridge grammar of the English language(2002) in which the morphological nature of the compound determinative category reflects a fusion of functions, typically determiner (or modifier) and head of NP. We refine the notion of fusion of functions, and show that constructions which employ fusion of functions have properties which clearly distinguish them from superficially similar constructions which employ incorporation or hybridization. The paper therefore provides further evidence for the existence of fusion of functions as a distinct syntactic configuration, and indirectly supports theoretical frameworks which treat functions and categories as distinct primitives.
A (phrasal) affix analysis of the Persian Ezafe
Authors: SAMVELIAN POLLET
Published: October 2007

This paper discusses the status of the Ezafe particle -(y)ein Persian and provides an affixal analysis of the Ezafe, formalized within Head-driven Phrase Structure Grammar (HPSG). The Ezafe, a feature of certain Western Iranian languages, is realized as an enclitic and links the head noun to its modifiers and to the possessor NP. The latter follow the head and are linked to one another by the Ezafe. On the basis of crucial empirical facts that have never been discussed in previous studies, I argue that the Ezafe is best regarded as an affix attaching to nominal heads (nouns, adjectives and some prepositions), as well as to nominal intermediate projections, and marking them as expecting a modifier or a direct nominal complement. Viewed as such, the Ezafe construction is an instance of the head-marked pattern of morphological marking of grammatical relations. This analysis differs from all previous accounts of the Ezafe (i.e. as case-marker, syntactic or phonological linker) and entails that the Ezafe, which originated in the Old Iranian relative particle -hya, has undergone a process of reanalysis-grammaticalization, to end up as a part of nominal morphology.
Inherent variability and Minimalism: Comments on Adger's ‘Combinatorial variability’
Authors: HUDSON RICHARD
Published: October 2007

Adger (2006) claims that the Minimalist Program provides a suitable theoretical framework for analysing at least one example of inherent variability: the variation betweenwasandwereafteryouandwein the Scottish town of Buckie. Drawing on the feature analysis of pronouns and the assumption that lexical items normally have equal probabilities, his analysis provides two ‘routes’ towe/you was, but only one towe/you were, thereby explaining why the former is on average twice as common as the latter. This comment points out four serious flaws in his argument: it ignores important interactions among sex, age and subject pronoun; hardly any social groups actually show the predicted average 2:1 ratio; there is no general tendency for lexical items to have equal probability of being used; the effects of the subject may be better stated in terms of the lexemesyouandwerather than as semantic features. The conclusion is that inherent variability supports a usage-based theory rather than Minimalism.
Anaesthetization and fixation effects on the morphology of sabellid polychaetes (Annelida: Polychaeta: Sabellidae)
Authors: Costa-Paiva Elisa Maria , Paiva Paulo Cesar , Klautau Michelle
Published: October 2007

One hundred and four specimens of Branchiomma luctuosum (Grube, 1870), a sabellid polychaete, were submitted to different anaesthetization and fixation procedures: a control group with living animals, immediate fixation with formaldehyde 4% (FO), ethanol 100% (AE) or ethanol 70% (ET), and anaesthetization with magnesium chloride (MC), refrigeration (RE), menthol crystals (ME) or freshwater (FW). Twenty-three morphometric variables of the body were measured and analysed with size-free multivariate statistics. The first three canonical variables explained 80% of the variation, being significantly correlated with 19 measured variables, mainly those related to the shape of the body setigers. Besides morphometric variables, some morphological characters commonly used in polychaete taxonomy also presented variation among fixation procedures, such as the release of parapodial elements and the integument. Among the procedures tested, AE, ET and FW were the best in approximating the shape of living specimens. Specimens submitted to FO and RE had shorter, wider, and thicker bodies, whereas those submitted to MC and ME were more elongated, narrower, flatter, and had wider pygidia than living specimens. Lengths of branchial crown, setiger 1 and pygidium seem to be the most informative morphometric characters for taxonomic purposes since they did not present deformation due to fixation procedures.
Effects of short-term rain events on mobile macrofauna living on seawalls
Authors: Blockley David J. , Cole Victoria J. , People Julie , Palomo M. Gabriela
Published: October 2007

The distribution and abundance of intertidal organisms can be affected by short-term events, such as rain. We compared the effects of rain on intertidal mobile invertebrates in four common microhabitats with differing amounts of shelter (namely beds of oysters, coralline turf, bare patches and crevices) on sea walls in Sydney Harbour. There was an effect of rain on some, but not all taxa, although this was not consistent between locations or times. Effects of rain were observed for some species of gastropods and crustaceans, but not for polychaetes. Manipulative experiments using artificial rain indicated that rain, without the presence of run-off and independent of potential temporal confounding from differences in weather conditions, has a negative effect on abundances of amphipods in coralline turf. Pulse responses by mobile organisms to short-term rain events should be considered when designing experiments looking at temporal variability and processes responsible for observed patterns of distribution of marine organisms.
A new species of Synelmis (Annelida: Polychaeta: Pilargidae) from the continental slope off Galicia (north-western Iberian peninsula)
Authors: Moreira Juan , Parapar Julio
Published: October 2007

A new species of Synelmis (Annelida: Polychaeta: Pilargidae), Synelmis urgorrii sp. nov., is described from the continental slope off north-western Spain. The new species is characterized by having antennae, peristomial cirri and parapodial cirri cirriform, lateral antennae located in the proximal third of the prostomium, notospines starting on chaetigers 7–11, well-developed neuropodial lobe and asymmetrical furcate chaetae, those of anterior chaetigers distinctly spinulated.
No effect of group size on sex allocation in a protandric-simultaneous hermaphroditic shrimp
Authors: Baeza J. Antonio
Published: October 2007

Lysmata wurdemanni is a protandric-simultaneous hermaphroditic shrimp. Individuals reproduce as males first and late in life as simultaneous hermaphrodites. I examined whether sex allocation (resources devoted to ova vs sperm) varies with group size in shrimps that have just matured as hermaphrodites. Focal males were reared with different numbers of hermaphrodites (1, 2, 5 or 10). Sperm stored in the ejaculatory ducts and eggs brooded underneath the abdomen were retrieved and weighted immediately after focal shrimps matured as hermaphrodites. Hermaphrodites should invest more into sperm with increasing group size to cope with more intense sperm competition. The proportion of focal shrimps that lost their first clutch of eggs after maturing as hermaphrodites increased with group size. This suggests male gender preferences by hermaphrodites experiencing large group sizes. No differences in sex allocation among group sizes were recorded for shrimps that did not lose their first clutch of eggs. Thus, group size does not affect sex allocation in terms of ova and sperm mass. This lack of phenotypic plasticity might be explained if sperm competition is not important in L. wurdemanni. It should not pay in terms of fitness for shrimps to produce and inseminate female-role hermaphrodites with large amounts of sperm when full paternity is assured in the absence of multi-male mating. In agreement with this idea, a second experiment demonstrated that female-role hermaphrodites invariably mated only once with a single other shrimp.
“AN VNDER BLACK DUBBLETT SIGNIFYING A SPANISH HART”: COSTUMES AND POLITICS IN MIDDLETON'sA GAME AT CHESS
Authors: Lublin Robert I.
Published: October 2007

Thomas Middleton'sA Game at Chesshas long held a place of particular importance in studies of early modern English theatre history. Performed for a record nine straight performances (a feat not accomplished again until the Restoration), Middleton's production has attracted scholarly interest by virtue of both its unparalleled contemporary success and its overt religious and political messages of anti-Catholic and anti-Spanish propaganda. Performed by the King's Men at the Globe playhouse between 5 and 14 August (except for Sunday) 1624,A Game at Chessprovides the most conspicuous instance from the period in which the stage addressed issues of immediate political significance. Certainly history plays, such as Shakespeare's series of works chronicling the Wars of the Roses, dealt with English politics, but no play dealt so directly with the politics of the moment. Even more important, the politics of the moment responded. John Woolley, the secretary of the English agent in Brussels, wrote “all the nues I have heard since my comming to towne is of a nue Play. It is called a game at Chess, but it may be a vox populy for by reporte it is 6 tymes worse against the Spanyard.” The play's politics struck such a chord and the performance was deemed so scandalous that it was ultimately shut down by King James himself after he received an official complaint from the Spanish Ambassador Extraordinary, Don Carlos Coloma.
TASTELESS AS HELL: COMMUNITY PERFORMANCE, DISTINCTION, AND COUNTERTASTE IN HELL HOUSE
Authors: Fletcher John
Published: October 2007

It's 10∶30 at night, the day after Halloween 2003. I'm standing in line outside of the Freedom Assembly of God Church in Tallahassee, Florida, to watch their first annual Hell House. Every October, hundreds of congregations across America mount religious dramas conceived as Christian Halloween alternatives. Such productions typically invoke and alter haunted-house conventions, replacing ghosts and monsters with demons and sin—all designed to confront unsaved audience members with the reality of spiritual warfare and the necessity of being born again. Whereas the Tallahassee version promised to be relatively modest, many other Hell House events boast huge production budgets and attract thousands of visitors annually. In recent years, these shows have garnered considerable media attention for their shocking, graphically staged scenes of “sin” and its consequences. Infamous images include gay people dying of AIDS and burning in hell, black-clad, Columbine-style gunmen mowing down Christians in schools, and blood-soaked abortions featuring vacuum-cleaner noises and bowls of raw meat meant to resemble fetuses. Criticism pours in from both left-wing advocacy groups and other evangelical Christians. It's “pornography for the soul,” it's “simplistic theology,” it's “spiritual violence.”
STOCHASTIC COMPARISONS OF PARALLEL SYSTEMS WHEN COMPONENTS HAVE PROPORTIONAL HAZARD RATES
Authors: Kochar Subhash , Xu Maochao
Published: October 2007

Let X1, … , Xn be independent random variables with Xi having survival function Fλi, i = 1, … , n, and let Y1, … ,Yn be a random sample with common population survival distribution F, where c = ∑i=1nλi/n. Let Xn:n and Yn:n denote the lifetimes of the parallel systems consisting of these components, respectively. It is shown that Xn:n is greater than Yn:n in terms of likelihood ratio order. It is also proved that the sample range Xn:n − X1:n is larger than Yn:n − Y1:n according to reverse hazard rate ordering. These two results strengthen and generalize the results in Dykstra, Kochar, and Rojo [6] and Kochar and Rojo [11], respectively.
FRACTAL AND RESISTANCE DIMENSIONS OF RANDOM TREES
Authors: Konsowa Mokhtar H. , Al-Jarallah Reem A.
Published: October 2007

In this article we determine a formula for fractal and resistance dimensions of two models of uniformly bounded random trees. The type (transient or recurrent) of the random walk on such trees is ascribed, to some extent, to these dimensions. The results presented in this article generalize some of the results of [6] and [7].