bluuebunny/crossref_metadata_2025 huggingface dataset:
A Climate Downscaling Deep Learning Model considering the Multiscale Spatial Correlations and Chaos of Meteorological Events
Authors: Mu Bin , Qin Bo , Yuan Shijin , Qin Xiaoyun
Published: November 2020

Climate downscaling is a way to provide finer resolution data at local scales, which has been widely used in meteorological research. The two main approaches for climate downscaling are dynamical and statistical. The traditional dynamical downscaling methods are quite time- and resource-consuming based on general circulation models (GCMs). Recently, more and more researchers construct a statistical deep learning model for climate downscaling motivated by the single-image superresolution (SISR) process in computer vision (CV). This is an approach that uses historical climate observations to learn a low-resolution to high-resolution mapping and produces great enhancements in terms of efficiency and effectiveness. Therefore, it has provided an appreciable new insight and successful downscaling solution to multiple climate phenomena. However, most existing models only make a simple analogy between climate downscaling and SISR and ignore the underlying dynamical mechanisms, which leads to the overaveraged downscaling results lacking crucial physical details. In this paper, we incorporate the a priori meteorological knowledge into a deep learning formalization for climate downscaling. More specifically, we consider the multiscale spatial correlations and the chaos in multiple climate events. Depending on two characteristics, we build up a two-stage deep learning model containing a stepwise reconstruction process and ensemble inference, which is named climate downscaling network (CDN). It can extract more local/remote spatial dependencies and provide more comprehensive captures of extreme conditions. We evaluate our model based on two datasets: climate science dataset (CSD) and benchmark image dataset (BID). The results demonstrate that our model shows the effectiveness and superiority in downscaling daily precipitation data from 2.5 degrees to 0.5 degrees over Asia and Europe. In addition, our model exhibits better performance than the other traditional approaches and state-of-the-art deep learning models.
Determination of Macro- and Microelements in the Inflorescences of Banana Tree Using ICP OES: Evaluation of the Daily Recommendations of Intake for Humans
Authors: Rosa Rafaela Henriques , Ribeiro Fernandes Melina , Silva de Pádua Melo Elaine , Granja Arakaki Daniela , Vieira de Lima Nayara , Santos Leite Luana Carolina , Espindola Paulo Renato , Domingos de Souza Igor , Aragão do Nascimento Valdir , Saldanha Tschinkel Paula Fabiana , La Flor Ziegler Sanches Fabiane , Aragão do Nascimento Valter
Published: November 2020

The inflorescence of Musa paradisiaca, known as “banana heart” is a structure that includes flowers and bracts of banana, commonly used as food source worldwide. The aims of this study were (1) to determine the mineral components of Musa paradisiaca and (2) to compare the obtained results with previously reported data of Recommendation Dietary Allowances (RDAs) and edible plant permissible limits set by FAO/WHO. The samples were digested using microwave-assisted equipment, while elemental contents were determined by inductively coupled plasma optical emission spectroscopy (ICP OES). Metal (Mg, Ca, Cr, Ni, Cu, Fe, and Zn) and nonmetal (S and P) contents were detected. According to RDA, the inflorescences could be excellent sources of Mg, P, Cr, Cu, Zn, and Fe for females, males, and pregnant women, all age 31–50 y, as well as children (4–8 y). Bracts are good source of Zn for male and pregnant women and good source of Fe for children. All the samples contained considerable amounts of Mg, Ca, P, Ni, Cu, Zn, and Fe, which were quite low to induce deleterious effects (UL). FAO/WHO limits for edible plants have not yet been established for S, P, Mg, and Ca, but Ni and Zn are below of those limit values. However, Cr and Cu concentrations are higher than the values established for edible plants and may pose a threat to human health. Farmers should be encouraged by government agencies, not only for sustainability of production but also to ensure the storage and trade of banana tree inflorescence.
Distributed Fiberoptic Sensor for Simultaneous Temperature and Strain Monitoring Based on Brillouin Scattering Effect in Polyimide-Coated Fibers
Authors: Sheng Liwen , Li Ligong , Hu Leijun , Yuan Ming , Lang Jinpeng , Wang Jianguo , Li Peng , Bi Zongyi , Yan Jisong , Liu Zhiming
Published: November 2020

A unique multiparameter sensor for distributed measurement of temperature and strain based on spontaneous Brillouin scattering in polyimide-coated optical fiber is proposed, which is an excellent candidate for the cross-sensitivity problem in conventional Brillouin sensing network. In the experimental section, the discrimination of strain and temperature is successfully demonstrated by analysing the unequal sensing coefficients of the Brillouin frequency shifts generated by different acoustic modes. The Brillouin frequency shifts of the main two peaks are successfully measured to discriminate the strain and temperature with an accuracy 19.68 με and 1.02°C in 2.5 km sensing range. The proposed distributed Brillouin optical fiber sensor allows simultaneous measurement of temperature and strain, thus opening a door for practical application such as oil explorations.
Preparation of Magnetic Molecularly Imprinted Polymers for Selective Recognition and Determination of Clenbuterol in Pork Samples
Authors: Zhao Yingjuan , Feng Zufei , Li Sijin , Lu Yan , Hu Yangfan , Fan Hua , Zhai Xinyue
Published: November 2020

Magnetic molecularly imprinted polymer (MMIP) was successfully synthesized with acrylamide as a functional monomer and clenbuterol (CLB) as a template molecule. The synthesized MMIPs were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectrometry (FT-IR). MMIPs were used to identify and bind CLB as a solid phase extraction material. The experiment data were fitted by the Freundlich isotherm adsorption model. The results show that MMIPs have excellent recognition performance for CLB. MMIPs were successfully applied as adsorbents to preconcentrated CLB in pork samples and detected by HPLC with UV. The limit of detection (LOD) and limit of quantification (LOQ) were 4.27 μg/L and 14.2 μg/L, respectively. The spiked recovery rates ranged from 94.44% to 102.29%. Therefore, the prepared MMIPs can be used for selective preconcentration of CLB content in complex animal-derived food samples.
Factors Affecting Compliance of Infection Control Measures among Dental Radiographers
Authors: Alakhras Maram , Al-Mousa Dana S. , Mahasneh Arwa , AlSa’di Amani G.
Published: November 2020

Objectives. To assess the level of dental radiographers’ compliance with infection control measures and to evaluate the factors affecting their compliance. Methods. The study included 175 dental radiographers. Compliance with infection control was evaluated with a self-administered questionnaire consisting of 33 questions related to vaccination, hand hygiene (HH), personal protective equipment (PPE), disinfection and sterilization, and use of surface barriers. Pearson’s chi-square test was used to compare compliance between subgroups of radiographers. Results. 64.6% of participants were females, and 62.9% was younger than 30 years. 13.0% of the sample population had >10 years of experience and 28.0% take radiographs for >20 patients/day. 66.9% of participants wash their hands before/after taking radiographs. 26.3% of participants had vaccination against hepatitis B, tetanus, and tuberculosis. 12.6% fully use PPE, 10.9% perform complete disinfection and sterilization, and 16.0% apply all kinds of surfaces barriers. Vaccination was significantly affected by age, gender, and practice type. HH was affected by years of experience and number of patients radiographed per day. PPE was influenced by number of hours worked per week and patients radiographed daily. Disinfection and sterilization was affected by practice type and years of experience. The use of surface barriers was affected by age, practice type, and number of patients radiographed/day. Conclusions. The current study indicated poor compliance with infection control practices among dental radiographers. We recommend continuing educational programs and training courses to increase dental radiographers’ awareness of local and international infection control guidelines and to enhance their implementation of these guidelines.
On Fuzzy Fixed Points and an Application to Ordinary Fuzzy Differential Equations
Authors: Ameer Eskandar , Aydi Hassen , Arshad Muhammad
Published: November 2020

The aim of this paper is to obtain the common fuzz fixed points ofα-fuzzy mappings satisfying generalized almostY,Λ-contraction in complete metric spaces. Our results are extensions and improvements of the several well-known recent and classical results in literature. We give an example for supporting these results. As an application, we apply our obtained results to study the existence of a solution for a second order nonlinear boundary value problem.
Cross-Organization Emergency Response Process Mining: An Approach Based on Petri Nets
Authors: Liu Cong , Li Huiling , Zeng Qingtian , Lu Ting , Li Caihong
Published: November 2020

To support effective emergency disposal, organizations need to collaborate with each other to complete the emergency mission that cannot be handled by a single organization. In general, emergency disposal that involves multiple organizations is typically organized as a group of interactive processes, known as cross-organization emergency response processes (CERPs). The construction of CERPs is a time-consuming and error-prone task that requires practitioners to have extensive experience and business background. Process mining aims to construct process models by analyzing event logs. However, existing process mining techniques cannot be applied directly to discover CERPs since we have to consider the complexity of various collaborations among different organizations, e.g., message exchange and resource sharing patterns. To tackle this challenge, a CERP model mining method is proposed in this paper. More specifically, we first extend classical Petri nets with resource and message attributes, known as resource and message aware Petri nets (RMPNs). Then, intra-organization emergency response process (IERP) models that are represented as RMPNs are discovered from emergency drilling event logs. Next, collaboration patterns among emergency organizations are formally defined and discovered. Finally, CERP models are obtained by merging IERP models and collaboration patterns. Through comparative experimental evaluation using the fire emergency drilling event log, we illustrate that the proposed approach facilitates the discovery of high-quality CERP models than existing state-of-the-art approaches.
An Experimental Study on the Basic Mechanical Properties and Compression Size Effect of Rubber Concrete with Different Substitution Rates
Authors: Hu Yanli , Sun Xuewei , Ma Aiqun , Gao Peiwei
Published: November 2020

An experimental study was carried out on the uniaxial compression, uniaxial splitting, pure shear, and compression size effect of rubber concrete with 5 different substitution rates by applying hydraulic servo and direct shear apparatus. Then, by comparing the failure modes and ultimate strength eigenvalues of rubber concrete under different loading conditions, the following conclusions were drawn: with the increase of rubber substitution rate, the concrete specimens maintain a relatively good integrity under uniaxial compressive failure; on the contrary, the failure sections under uniaxial slitting and pure shear gradually become uneven with an increasing amount of fallen rubber particles. With the increase of specimen size, the integrity of rubber concrete after failure is gradually improved. Affected by an increased rubber substitution rate, the uniaxial compressive strength, splitting tensile strength, and shear strength of the concrete gradually decrease, while the plastic deformation capacity gradually increases. Specifically, the compressive strength is reduced by a maximum of 60.67%; the shear strength is reduced by a maximum of 49.85%; and the uniaxial splitting strength is reduced by a maximum of 58.38%. Then, we analyzed the strength relationship and the underlying mechanism among the three types of loading modes. It is found that, at the same rubber substitution rate, the compressive strength of rubber concrete gradually increases as the specimen size decreases, and the size effect on the compressive strength gradually decreases as the rubber substitution rate increases. Meanwhile, we performed qualitative and quantitative analysis on the equation describing the coupling effect of specimen size and rubber substitution rate on the compressive strength; the results suggest that the proposed equation is of a high level of applicability. Our research has a reference value for the application and promotion of rubber concrete in actual engineering projects.
The ILHWLAD-MCDM Framework for the Evaluation of Concrete Materials under an Intuitionistic Linguistic Fuzzy Environment
Authors: Chen Junjie , Zhang Chonghui , Li Peipei , Xu Mingxiao
Published: November 2020

Concrete, one of the sources of energy consumption and carbon emissions, is widely used in the construction industry. The selection of concrete materials raises the question of energy sustainability and turns it into a complex multicriteria decision-making (MCDM) issue. To address this, we present an MCDM framework based on the intuitionistic linguistic hybrid weighted logarithmic averaging distance (ILHWLAD). To begin with, the intuitionistic linguistic numbers are used to deal with the uncertainty and fuzziness of the decision-making process. In addition, in view of the significance and the ordered position of the input arguments, an intuitionistic linguistic hybrid weighted logarithmic averaging distance (ILHWLAD) operator is defined. We, then, initiate the criteria system and present the MCDM framework based on the ILHWLAD to select the finest concrete. A case study involving four alternative materials, namely, autoclaved aerated concrete (AAC), hollow concrete blocks (HCB), expanded polystyrene (EPS), and lime hemp concrete (LHC), is presented to verify the scientificity of the framework.
Numerical Simulation Study on the Influence of Different Factors on the Uplift Bearing Capacity of Root Piles, Straight‐Shaft Piles, and Pedestal Piles
Authors: Zhou Junpeng , Yuan Jun , Huang Xuefeng , Wang Xueming
Published: November 2020

Root pile (hereafter called RP), which is a promising new type of noncircular cross‐section‐shaped pile and meets the requirements of the development of the uplift pile, was introduced for promotion. On the basis of validation of experimental and numerical results, finite element models were established to study the influence of the arrangement of roots and dimension parameters on the uplift bearing capacity and the economy of RP compared with that of the straight‐shaft pile and pedestal pile (hereafter called SP and PP, respectively). The results show that the uplift bearing capacity of RP is higher than that of SP and PP, and the longer the pile length is, the more the bearing capacity of RP would increase compared with that of SP and PP. In order to further improve the bearing capacity of RP, the bearing mechanism of the root was analysed, and the suggested values of root size and spacing of layers are given. In addition, the most economical way to increase pile bearing capacity is to increase pile length rather than increasing pile diameter.
A Prediction Approach for Video Hits in Mobile Edge Computing Environment
Authors: Liu Xiulei , Hou Shoulu , Tong Qiang , Liu Xuhong , Qin Zhihui , Yu Junyang
Published: November 2020

Smart device users spend most of the fragmentation time in the entertainment applications such as videos and films. The migration and reconstruction of video copies can improve the storage efficiency in distributed mobile edge computing, and the prediction of video hits is the premise for migrating video copies. This paper proposes a new prediction approach for video hits based on the combination of correlation analysis and wavelet neural network (WNN). This is achieved by establishing a video index quantification system and analyzing the correlation between the video to be predicted and already online videos. Then, the similar videos are selected as the influencing factors of video hits. Compared with the autoregressive integrated moving average (ARIMA) and gray prediction, the proposed approach has a higher prediction accuracy and a broader application scope.
A Vortex Identification Method Based on Extreme Learning Machine
Authors: Wang Jun , Guo Lei , Wang Yueqing , Deng Liang , Wang Fang , Li Tong
Published: November 2020

Vortex identification and visualization are important means to understand the underlying physical mechanism of the flow field. Local vortex identification methods need to combine with the manual selection of the appropriate threshold, which leads to poor robustness. Global vortex identification methods are of high computational complexity and time-consuming. Machine learning methods are related to the size and shape of the flow field, which are weak in versatility and scalability. It cannot be extended and is suitable for flow fields of different sizes. Recently, proposed deep learning methods have long network training time and high computational complexity. Aiming at the above problems, we present a novel vortex identification method based on the Convolutional Neural Networks-Extreme Learning Machine (CNN-ELM). This method transforms the vortex identification problem into a binary classification problem, and can quickly, objectively, and robustly identify vortices from the flow field. A large number of experiments prove the effectiveness of our method, which can improve or supplement the shortcomings of existing methods.
Decisions of E-Commerce Supply Chain under Consumer Returns and Different Power Structures
Authors: Shen Liang , Fan Runjie , Wang Yuyan
Published: November 2020

Considering the growing phenomenon of consumer returns and channel power struggles in e-commerce supply chains (ESCs), the ESC model is constructed and its equilibrium solutions are calculated and compared. Further, the consumer utility function is constructed to explore the impact of returns and dominant enterprises on consumer utility. Based on this, the “return cost-sharing and commission readjusting” contract is designed to maximize both ESC and consumer utility. Finally, the paper validates and further analyzes conclusions through numerical simulation. The main conclusions are as follows: higher return rates and return handling costs will reduce market demand and ESC profits, while higher salvage value of returned products will have a positive impact on ESC, but the above factors will not affect the online service level under decentralized decisions. The impact of consumer’s service quality preferences on manufacturer’s profits and e-commerce platform’s profit is determined by channel power structure. The impact of return rate on consumer utility depends on two factors: the decision-making model and the hidden cost of consumer returns.
Intelligent Video Surveillance Technology in Intelligent Transportation
Authors: He Fangcheng
Published: November 2020

Along with the strength of the country’s overall strength, the people’s pockets have become more and more popular, and there have been significant improvements in all aspects of life, especially in terms of travel methods. This reflects the increase in residents’ income, but it also brings huge traffic pressure. In the long run, traffic congestion is not only detrimental to urban development, but frequent traffic accidents threaten residents’ travel safety. Effective monitoring methods are essential to solving these problems, so it is necessary to carry out research on intelligent video monitoring technology in intelligent transportation. The purpose of this article is to solve the current situation of excessive traffic pressure in the city. Through the study of intelligent video surveillance technology in intelligent traffic, the use of constrained least squares algorithm to remove motion blur and apply Kalan filtering to the sharpening process is used to eliminate noise ambiguity and make a brief introduction to various classic moving target detection methods to realize real-time monitoring of intelligent traffic conditions and continuously adjust and verify the monitoring situation, and then establish intelligent video in intelligent traffic monitoring technology research system. The research results show that this kind of intelligent video surveillance technology research in intelligent transportation can effectively increase the awareness of intelligent video surveillance technology and improve the level of intelligent video surveillance technology. The data measurement time has been shortened by one hour, the aggregation time has been changed from three hours to two hours, and the analysis time has been shortened by half. Eased urban traffic road pressure and greatly reduced the incidence of traffic accidents, which is conducive to socialist harmony social construction.
A New Approach to Newton-Type Polynomial Interpolation with Parameters
Authors: Zou Le , Song Liangtu , Wang Xiaofeng , Weise Thomas , Chen Yanping , Zhang Chen
Published: November 2020

Newton’s interpolation is a classical polynomial interpolation approach and plays a significant role in numerical analysis and image processing. The interpolation function of most classical approaches is unique to the given data. In this paper, univariate and bivariate parameterized Newton-type polynomial interpolation methods are introduced. In order to express the divided differences tables neatly, the multiplicity of the points can be adjusted by introducing new parameters. Our new polynomial interpolation can be constructed only based on divided differences with one or multiple parameters which satisfy the interpolation conditions. We discuss the interpolation algorithm, theorem, dual interpolation, and information matrix algorithm. Since the proposed novel interpolation functions are parametric, they are not unique to the interpolation data. Therefore, its value in the interpolant region can be adjusted under unaltered interpolant data through the parameter values. Our parameterized Newton-type polynomial interpolating functions have a simple and explicit mathematical representation, and the proposed algorithms are simple and easy to calculate. Various numerical examples are given to demonstrate the efficiency of our method.
Psychometric properties of a Spanish version of the 10-item Berger's stigma scale in Colombia: a validation study
Authors: Montaño David , Martínez-Cajas Jorge , Balfour Louise , Mueses Héctor Fabio , Galindo Jaime , Alvarado Beatriz
Published: November 2020

Introduction: HIV-related stigma is detrimental to people living with HIV (PLH), and reducing it is essential for achieving an HIV/AIDS-free generation. Abbreviated stigma scales can improve the feasibility of surveys that broadly explore factors affecting PLH. This study tested the psychometric properties of a Spanish translation of the abbreviated 10-item Berger's HIV stigma scale. Methods: We recruited a sample of 105 PLH regularly attending a specialized clinic in Cali, Colombia. English-to-Spanish and Spanish-to-English back translation was performed of the Berger's 10-item HIV stigma scale. Exploratory and confirmatory factor analyses were carried out to assess its validity. Pre- and post-test reliability (15 days) was estimated with the intra-class correlation coefficient (ICC). Results: The Confirmatory Factor Analysis (CFA) was used to confirm a two-factor solution with three poor items removed, resulting in a 7-item HIV Stigma Scale. The resulting 7-item HIV stigma scale had a Cronbach's alpha of 0.73 with an ICC of 0.83 (CI 95%: 0.75–0.89). One factor loaded three items related to negative self-image (internalised stigma), and the other four items were related to personalized (enacted) HIV stigma. Both factors were related to depression and adherence to antiretroviral therapy. Conclusion: The Spanish translation of the 10-item HIV stigma scale did not perform well due to problems in items 4, 5, and 6. Rather, a modified 7-item version had a good fit with a two-factor loading in which both HIV stigma factors correlated significantly with depression and HIV medication adherence.
Implicaciones en el movimiento humano de las adaptaciones del esquema e imagen corporal secundarias a una amputación
Authors: Reséndiz  Vega Hugo Ricardo , Serrano Rosales Mónica Mariana
Published: November 2020

Introducción: el movimiento corporal humano es el resultado de la interacción entre elementos psicológicos, biológicos y sociales. Las amputaciones generan alteraciones en la estructura mental del individuo ocasionando restricciones en la participación social; por ello, es necesario comprender la influencia de la imagen y el esquema corporal de los sujetos con amputación según la teoría del movimiento continuo. Métodos: se realizó una revisión de la literatura en las bases de datos PubMed, Science Direct, Clinical Key, PEDro, SciELO en el mes de abril de 2020; la selección de artículos se dividió en 3 fases, utilizando los términos “body schema”, “body image”, “amputee” y “movement”. Resultados: se encontró un total de 142 artículos, de los cuales se incluyeron 13 que cumplían con los criterios de selección. Discusión: posterior a una amputación se producen alteraciones de la imagen y el esquema corporal, además de cambios plásticos en el sistema nervioso central; derivado de esto existirán modificaciones en el movimiento corporal de la persona. Se requiere favorecer el manejo integral del sujeto con amputación basado en la teoría del movimiento continuo abarcando esferas psicológicas, biológicas y sociales. Conclusión: la aceptación e integración de la imagen y esquema corporal son fundamentales para restablecer la capacidad máxima de movimiento de la persona con amputación.
Decitabine Induces Gene Derepression on Monosomic Chromosomes: In Vitro and In Vivo Effects in Adverse-Risk Cytogenetics AML
Authors: Greve Gabriele , Schüler Julia , Grüning Björn A. , Berberich Bettina , Stomper Julia , Zimmer Dennis , Gutenkunst Lea , Bönisch Ulrike , Meier Ruth , Blagitko-Dorfs Nadja , Grishina Olga , Pfeifer Dietmar , Weichenhan Dieter , Plass Christoph , Lübbert Michael
Published: November 2020

Hypomethylating agents (HMA) have become the backbone of nonintensive acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) treatment, also by virtue of their activity in patients with adverse genetics, for example, monosomal karyotypes, often with losses on chromosome 7, 5, or 17. No comparable activity is observed with cytarabine, a cytidine analogue without DNA-hypomethylating properties. As evidence exists for compounding hypermethylation and gene silencing of hemizygous tumor suppressor genes (TSG), we thus hypothesized that this effect may preferentially be reversed by the HMAs decitabine and azacitidine. An unbiased RNA-sequencing approach was developed to interrogate decitabine-induced transcriptome changes in AML cell lines with or without a deletion of chromosomes 7q, 5q or 17p. HMA treatment preferentially upregulated several hemizygous TSG in this genomic region, significantly derepressing endogenous retrovirus (ERV)3–1, with promoter demethylation, enhanced chromatin accessibility, and increased H3K4me3 levels. Decitabine globally reactivated multiple transposable elements, with activation of the dsRNA sensor RIG-I and interferon regulatory factor (IRF)7. Induction of ERV3–1 and RIG-I mRNA was also observed during decitabine treatment in vivo in serially sorted peripheral blood AML blasts. In patient-derived monosomal karyotype AML murine xenografts, decitabine treatment resulted in superior survival rates compared with cytarabine. Collectively, these data demonstrate preferential gene derepression and ERV reactivation in AML with chromosomal deletions, providing a mechanistic explanation that supports the clinical observation of superiority of HMA over cytarabine in this difficult-to-treat patient group.

Significance:

These findings unravel the molecular mechanism underlying the intriguing clinical activity of HMAs in AML/MDS patients with chromosome 7 deletions and other monosomal karyotypes.

See related commentary by O'Hagan et al., p. 813
Neratinib-Plus-Cetuximab in Quadruple-WT (KRAS, NRAS, BRAF, PIK3CA) Metastatic Colorectal Cancer Resistant to Cetuximab or Panitumumab: NSABP FC-7, A Phase Ib Study
Authors: Jacobs Samuel A. , Lee James J. , George Thomas J. , Wade James L. , Stella Philip J. , Wang Ding , Sama Ashwin R. , Piette Fanny , Pogue-Geile Katherine L. , Kim Rim S. , Gavin Patrick G. , Lipchik Corey , Feng Huichen , Wang Ying , Finnigan Melanie , Kiesel Brian F. , Beumer Jan H. , Wolmark Norman , Lucas Peter C. , Allegra Carmen J. , Srinivasan Ashok
Published: November 2020

Purpose:

In metastatic colorectal cancer (mCRC), HER2 (ERBB2) gene amplification is implicated in anti-EGFR therapy resistance. We sought to determine the recommended phase II dose (RP2D) and efficacy of neratinib, a pan-ERBB kinase inhibitor, combined with cetuximab, in patients with progressive disease (PD) on anti-EGFR treatment.

Patients and Methods:

Twenty-one patients with quadruple-wild-type, refractory mCRC enrolled in this 3+3 phase Ib study. Standard dosage cetuximab was administered with neratinib at 120 mg, 160 mg, 200 mg, and 240 mg/day orally in 28-day cycles. Samples were collected for molecular and pharmacokinetic studies.

Results:

Sixteen patients were evaluable for dose-limiting toxicity (DLT). 240 mg was determined to be the RP2D wherein a single DLT occurred (1/7 patients). Treatment-related DLTs were not seen at lower doses. Best response was stable disease (SD) in 7 of 16 (44%) patients. HER2 amplification (chromogenic in situ IHC) was detected in 2 of 21 (9.5%) treatment-naïve tumors and 4 of 16 (25%) biopsies upon trial enrollment (post-anti-EGFR treatment and progression). Compared with matched enrollment biopsies, 6 of 8 (75%) blood samples showed concordance for HER2 CNV in circulating cell-free DNA. Five SD patients had HER2 amplification in either treatment-naïve or enrollment biopsies. Examination of gene-expression, total protein, and protein phosphorylation levels showed relative upregulation of ≥2 members of the HER-family receptors or ligands upon enrollment versus matched treatment-naïve samples.

Conclusions:

The RP2D of neratinib in this combination was 240 mg/day, which was well tolerated with low incidence of G3 AEs. There were no objective responses; SD was seen at all neratinib doses. HER2 amplification, detectable in both tissue and blood, was more frequent post-anti-EGFR therapy.
Downregulation of Xeroderma Pigmentosum Complementation Group C Expression by 17-Allylamino-17-Demethoxygeldanamycin Enhances Bevacizumab-Induced Cytotoxicity in Human Lung Cancer Cells
Authors: Chen Jyh-Cheng , Ko Jen-Chung , Taso Yong-Cing , Cheng Hsiang-Hung , Chen Tzu-Ying , Yen Ting-Chuan , Lin Yun-Wei
Published: November 2020

Introduction: Xeroderma pigmentosum complementation group C (XPC) protein is an important DNA damage recognition factor involved in nucleotide excision repair and regulation of non-small-cell lung cancer (NSCLC) cell proliferation and viability. 17-Allylamino-17-demethoxygeldanamycin (17-AAG) blocks ATP binding to heat shock protein 90 (Hsp90), resulting in destabilization of Hsp90-client protein complexes. Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor expressed by many types of tumors. Bevacizumab (Avastin) is a humanized monoclonal antibody against human VEGF used as an antiangiogenesis agent in the therapy of many cancers, proving successful in increasing objective tumor response rate and prolonging overall survival in NSCLC patients. Methods: After the bevacizumab and/or 17-AAG treatment, the expressions of XPC mRNA were determined by quantitative real-time PCR analysis. Protein levels of XPC and phospho-AKT were determined by Western blot analysis. We used specific XPC small interfering RNA and PI3K inhibitor (LY294002) to examine the role of the AKT-XPC signal in regulating the chemosensitivity of bevacizumab and 17-AAG. Cell viability was assessed by the MTS assay and trypan blue exclusion assay. Results: In this study, bevacizumab decreased XPC expression in human lung squamous cell carcinoma H520 and H1703 cells via AKT inactivation. Enhancement of AKT activity by transfection with constitutively active AKT vectors increased XPC expression and cell survival after treatment with bevacizumab. In addition, 17-AAG synergistically enhanced bevacizumab-induced cytotoxicity and cell growth inhibition in H520 and H1703 cells, associated with downregulation of XPC expression and inactivation of AKT. Discussion/Conclusion: Together, these results may provide a rationale to combine bevacizumab with Hsp90 inhibitors in future to enhance therapeutic effects for lung cancer.
Role of NLRP3 Inflammasomes in Neuroinflammation Diseases
Authors: Lin Sen , Mei Xifan
Published: November 2020

Background: Inflammasomes are large intracellular multi-protein signaling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1 and pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a nod-like receptor, the adapter apoptosis-associated speck-like protein, and caspase-1. Dysregulation of NLRP3 inflammasome activation is involved in neuroinflammation disease pathogenesis, although its role in SCI development and progression remains controversial due to the inconsistent findings described. Summary: In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential neuroinflammation diseases therapy.
Serum Concentration and Skin Expression of S100A7 (Psoriasin) in Patients Suffering from Hidradenitis Suppurativa
Authors: Batycka-Baran Aleksandra , Baran Wojciech , Nowicka-Suszko Danuta , Koziol-Gałczyńska Maria , Bieniek Andrzej , Matusiak Łukasz , Łaczmański Łukasz , Szepietowski Jacek Cezary
Published: November 2020

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. An important role of innate immune dysregulation in the pathogenesis of HS has been highlighted. S100A7 (psoriasin) is an innate, antimicrobial protein that exerts proinflammatory and chemotactic action. Objectives: The objective of the study was to investigate serum concentrations of S100A7 in individuals with HS as compared to healthy controls. Further, we evaluated the expression of S100A7 in lesional HS skin as compared to perilesional (clinically uninvolved) HS skin and normal skin. Methods: Serum concentrations of S100A7 were evaluated with a commercially available ELISA kit. The expression of S100A7 in the skin was assessed using qRT-PCR and immunofluorescence staining. Results: We found increased expression of S100A7 in lesional HS skin as compared to perilesional HS skin (p = 0.0017). The expression of S100A7 in lesional HS skin was positively associated with serum C-reactive protein concentration and the severity of disease according to Hurley staging. The serum concentration of S100A7 in individuals with HS was decreased as compared to healthy controls and patients with psoriasis. Conclusions: Upregulated in lesional HS skin, S100A7 may enhance the inflammatory process and contribute to the HS pathogenesis.
Can Hydroxychloroquine Cause G6PD-Related Hemolysis? A Case Study
Authors: Obeidat Khaldun , Yassin Mohamed A.
Published: November 2020

During the pandemic of COVID-19, which started in December 2019, hydroxychloroquine, the drug which was first introduced as antimalarial medication, was widely used to treat this new viral infection, and it was reported in the literature as a safe drug for use in patients with G6PD deficiency; here, we report a 64-year-old male who was started on hydroxychloroquine as treatment for COVID-19 that led to hemolysis, and further investigation showed that the patient is deficient for glucose-6-phosphate dehydrogenase.
Avaliação do alinhamento articular dinâmico dos membros inferiores e a relação com lesões e performance em patinadores
Authors: Cabral Mariana Carolina Maciel , Schmit Emanuelle Francine Detogni , Candotti Cláudia Tarragô
Published: November 2020

O objetivo deste estudo foi analisar o alinhamento articular dinâmico dos membros inferiores de patinadores artísticos sobre rodas e verificar a relação com o histórico de lesões e performance. Foram avaliadas 31 patinadoras (15,7±4,8 anos; 8,2±4,4 anos de prática da modalidade), acerca do alinhamento articular dinâmico dos membros inferiores (instrumento MADAAMI-P), do histórico de lesões e da performance (questionário). As análises estatísticas descritivas (média, desvio padrão, frequências) e inferenciais (teste de Shapiro-Wilk, correlação de Pearson/Spearman, teste t dependente/Wilcoxon, alpha=0,05) foram realizadas no software SPSS v. 20.0. Os resultados indicam que o início da fase competitivase dá por volta dos nove anos (9,1±3,1 anos), na frequência de quatro treinos semanais (4,4±0,7 treinos/semana), com ampla quantidade de medalhas obtidas no último ano (n=231). Quanto às lesões em membros inferiores, estas totalizaram 28, e os principais acometimentos envolveram joelho (n=09) e tornozelo (n=08), comumente relacionados à distensão e/ou estiramento (n=07). O alinhamento articular dinâmico dos membros inferiores foi de bom a excelente (escore mínimo de 53 e máximo de 99%). As correlações entre o alinhamento articular dinâmico dos membros inferiores com o histórico de lesões e com a performance não foram estatisticamente significativas, tanto quando avaliado o movimentode flexão, como quando o de semiflexão de joelhos, seja em relação ao alinhamento do arco do pé, do joelho ou da pelve. Conclui-se que o alinhamento articular dinâmico dos membros inferiores não é determinante de lesões na patinação nem de baixo desempenho na modalidade.
Leituras da relação entre cultura e Educação Física
Authors: Lara Larissa Michelle , Starepravo Fernando Augusto , Souza Vânia de Fátima Matias de , Miranda Antonio Carlos Monteiro de
Published: November 2020

O presente artigo discute a relação entre cultura e Educação Física nos contextos argentino, chileno e colombiano por meio da colaboração de professores-pesquisadores a partir do envio de questionários. Adensam esta análise o diálogo com a literatura, o acesso a documentos educacionais governamentais e a informações disponíveis em sites institucionais das universidades. Os resultados apontam para relações incipientes e periféricas entre a cultura e a Educação Física na produção de conhecimento e no campo escolar dos países investigados, as quais tendem a ser potencializadas a partir de interesses emergentes de pesquisadores que têm intensificado o diálogo com as ciências humanas e sociais no intuito de contribuircom a área.
Escala de percepção de esforço para criança (EPEC)
Authors: Martins Renata , Gonçalves Renata Maba , Minsky Rafaela Coelho , Mayer Anamaria Fleig , Schivinski Camila Isabel Santos
Published: November 2020

O objetivo do presente estudo é traduzir e validar, para a língua portuguesa do Brasil, a escala de percepção de esforço para crianças (EPEC). Para isto, toda a etapa de tradução da PES-C, da língua inglesa para a portuguesa (do Brasil), foi realizada com base no protocolo proposto por Guillemin et al.19. Para validação da escala, esta foi aplicada durante a realização do teste de caminhada de seis minutos (TC6). A validade daEPEC foi avaliada com o uso do coeficiente de correlação de Pearson, para verificar o grau de associação com a escala de Borg. Para a estabilidade das respostas, calculou-se o erro padrão da média (EPM) e coeficiente de correlação intra-classe (ICC). Calculou-se o erro padrão da estimativa das medidas de percepção finais (EPE) de cada dia para analisar o grau de desvio dos dados obtidos. Para avaliação da fidelidade utilizouse o alpha de Cronbach, no sentido de se analisar a consistência interna deste instrumento. Neste estudo participaram do processo de validação da EPEC 36 crianças, com média de idade de 10±2,61 anos, sendo 50% de meninas. No cálculo do EPM, encontrou-se um valor de 0,05 para o primeiro dia e 0,03 no segundo dia, caracterizando uma variabilidade baixa. O EPE foi de 0,33 no primeiro dia e 0,41 no segundo dia, demonstrando um erro baixo. A consistência interna apresentou coefi ciente alfa de Cronbach de 0,865. A escala EPEC foi validada para a população de crianças brasileiras, demonstrando também ser reprodutível em testes submáximos.
HQs, Educação e Arquitetura: um diálogo possível
Authors: Alcântara Cláudia Sales , Mendonça Emiliana Pereira
Published: November 2020

O presente trabalho tem como objetivo inserir as histórias em quadrinhos - HQs como auxílio no processo criativo das disciplinas de História da Arte, Introdução à Arquitetura, de Projeto Arquitetônico e em Técnicas Retrospectivas. Compreende-se que as HQs são uma ferramenta educacional muito eficaz, possuindo a capacidade de transmitir uma forma de ser, sentir, viver e se comportar no mundo, podendo ser utilizadas de maneira interdisciplinar nos diversos conteúdos acadêmicos.
Possibilidades pedagógicas em seis histórias em quadrinhos: um ensaio
Authors: Dias Rafael Cobbe , Santos Rodrigo Otavio dos
Published: November 2020

Neste artigo buscamos empreender um ensaio direcionado à prática pedagógica com o uso das histórias em quadrinhos para professores em sala de aula. Para tanto, selecionamos histórias interessantes e de fácil acesso para que os professores pudessem desenvolver não apenas as ideias aqui relacionadas, mas que também conseguissem, a partir delas, criar novas e melhores abordagens para as histórias em quadrinhos em sala de aula.
“Hard against the soul”, de Dionne Brand
Authors: Santos Tatiana Nascimento dos , Pascoal Priscila Francisco
Published: November 2020

Dionne Brand, poeta, novelista, documentarista e professora universitária, nasceu em Trinidad, uma ilha caribenha perto da Venezuela, e migrou para o Canadá na adolescência. Ganhadora de prêmios internacionais, como o “Governor General’s Award for Poetry” e o “Toronto Book Award”, é considerada ora caribenha ora canadense, apesar de reivindicar ser apátrida, e geralmente aborda temas como mulher, negritude, sexualidade, imigração, colonialismo, diáspora e justiça social. Alguns de seus trabalhos mais bem conhecidos e aclamados são o romance “What we all claim for”, o livro de poemas “thirsty”, o ensaio “Bread out of stone” e “A map to the door of no return”, uma meditação sobre negritude na diáspora.
O impacto das línguas bantas na formação do português brasileiro
Authors: Bagno Marcos
Published: November 2020

O impacto das línguas africanas sobre o português brasileiro foi durante muito tempo minimizado ou mesmo negado, sem dúvida por razões ideológicas advindas do profundo racismo vigente na sociedade brasileira. Investigações recentes, no entanto, comprovam, em bases teóricas consistentes, que muitas características exclusivas da gramática do português brasileiro, que o diferenciam não só do português europeu como de todas as demais línguas do grupo românico, se devem aos intensos contatos linguísticos ocorridos no longo período colonial entre as línguas dos escravos, sobretudo as do grupo banto, e o português.
Um editor dublê de tradutor: Entrevista com Marcos Marcionilo
Authors: Silva-Reis Dennys , Amorim Lauro Maia
Published: November 2020

Marcos Marcionilo é formado em filosofia pela Pontifícia Universidade Católica de São Paulo, onde seguiu um mestrado em filosofia contemporânea com estudos sobre a filosofia de Michel Foucault. Conhece as línguas francesa, italiana, espanhola, inglesa. Exerce a profissão de tradutor desde 1987, tendo traduzido livros como Introdução ao existencialismo, de Nicola Abbagnano; Filosofia da linguagem, de Sylvain Auroux; A invenção da paisagem, de Anne Cauquelin. Desde 2001, é sócio-editor da Parábola Editorial.
Grãos sacralizados: notas sobre a difusão popular do milho a partir do seu uso simbólico em rituais religiosos
Authors: Melchior Myriam , Sulis Marcella
Published: November 2020

Observar os significados simbólicos da cultura do milho no Brasil indica a sua importância como alimento de resistência, associado a uma sacralidade pouco visível à historiografia oficial. Na perspectiva do colonizador, o milho tinha pouca relevância além da econômica e não rivalizava com o trigo, cujo valor simbólico esteve associado ao cristianismo. Investigando as menções feitas ao milho na coletânea História da Alimentação, organizada por Flandrin e Montanari (2015), encontramos a ideia de que na Europa o milho foi recomendado apenas em períodos de crise de abastecimento. Diferentemente, no Brasil, notamos que a difusão do milho na alimentação popular se deveu, sobretudo, aos povos afrodescendentes, que adaptaram o seu uso doméstico e ritualístico. Embora sejam raras as informações sobre a utilização de alimentos nas religiões originais dos povos nativos e cativos, foi possível, através de estudos antropológicos e artísticos, comparar algumas práticas ritualísticas atuais herdeiras das etnias indígenas e afrodescendentes do período colonial brasileiro. A comparação mostra semelhanças entre os rituais religiosos afro-indígenas que apontam para o seu traço de união, que se mostrou valioso à sobrevivência do milho na alimentação brasileira. O estudo sobre a sacralidade do milho sinaliza para modos de transmissão de uma cultura alimentar envolta em embates entre as suas representações socioeconômicas e as suas potencialidades simbólicas, tanto mágicas como poéticas.
Os efeitos do NAFTA na destruição do México para justificar políticas comerciais transnacionais e alterações na cultura alimentar
Authors: Coelho-Costa Ewerton Reubens
Published: November 2020

A obra Eating NAFTA: Trade, Food Policies and the Destruction of Mexico (2018), de Alyshia Gálvez, publicada em inglês pela editora da Universidade da Califórnia, e ainda sem tradução no Brasil, esclarece detalhadamente e de maneira oportuna a relação entre a perda da biodiversidade, a migração, as alterações na cultura alimentar mexicana, as doenças relacionadas à dieta e os acordos comerciais internacionais. Com foco no Acordo de Livre Comércio da América do Norte (Nafta), em vigor desde 1994, analisa as duas décadas seguintes ao acordo evidenciando seu impacto na vida dos mexicanos que vivem nos dois lados da fronteira. Para além da obra resenhada, este texto apresenta os últimos desdobramentos que levaram às implicações e alteração do NAFTA transformando-o em Acordo Estados Unidos-México-Canadá (USMCA, na sigla em inglês para United States-Mexico-Canada Agreement).