bluuebunny/crossref_metadata_2025 huggingface dataset:
The sensitivity of magnetic particle imaging and fluorine-19 magnetic resonance imaging for cell tracking
Authors: Sehl Olivia C. , Foster Paula J.
Published: November 2021

Magnetic particle imaging (MPI) and fluorine-19 (19F) MRI produce images which allow for quantification of labeled cells. MPI is an emerging instrument for cell tracking, which is expected to have superior sensitivity compared to 19F MRI. Our objective is to assess the cellular sensitivity of MPI and 19F MRI for detection of mesenchymal stem cells (MSC) and breast cancer cells. Cells were labeled with ferucarbotran or perfluoropolyether, for imaging on a preclinical MPI system or 3 Tesla clinical MRI, respectively. Using the same imaging time, as few as 4000 MSC (76 ng iron) and 8000 breast cancer cells (74 ng iron) were reliably detected with MPI, and 256,000 MSC (9.01 × 1016 19F atoms) were detected with 19F MRI, with SNR > 5. MPI has the potential to be more sensitive than 19F MRI for cell tracking. In vivo sensitivity with MPI and 19F MRI was evaluated by imaging MSC that were administered by different routes. In vivo imaging revealed reduced sensitivity compared to ex vivo cell pellets of the same cell number. We attribute reduced MPI and 19F MRI cell detection in vivo to the effect of cell dispersion among other factors, which are described.
High species richness of tachinid parasitoids (Diptera: Calyptratae) sampled with a Malaise trap in Baihua Mountain Reserve, Beijing, China
Authors: Pei Wenya , Yan Liping , Pape Thomas , Wang Qike , Zhang Chuntian , Yang Nan , Du Fuxin , Zhang Dong
Published: November 2021

Tachinidae are one of the most speciose families of Diptera and the largest group of non-hymenopteran parasitoids. Little is known about their diversity, distribution patterns, and seasonal variation in most ecosystems. This study reports on tachinid flies collected by a Malaise trap over 73 weeks in Baihua Mountain Reserve, northern China, and investigates the patterns of local species richness and its temporal distribution. The most species-rich season was summer, but the majority of specimens were recovered in spring. A total of 755 tachinid specimens were collected, consisting of 144 species in 85 genera, comprising 26.5% of the species and 49.7% of the genera recorded from northern China. A total species richness of 243 was estimated, indicating that only a portion of the community of tachinid flies was collected at this location and suggesting that the diversity of tachinids might be underestimated across Beijing and northern China. This work is a first step in assessing patterns of tachinid diversity in China using quantitative sampling and establishes a baseline for comprehending the temporal and spatial diversity of these ecologically significant parasitoids.
Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells
Authors: Caohuy Hung , Eidelman Ofer , Chen Tinghua , Liu Shufeng , Yang Qingfeng , Bera Alakesh , Walton Nathan I. , Wang Tony T. , Pollard Harvey B.
Published: November 2021

To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike protein must first bind to the host receptor ACE2 protein on pulmonary and other ACE2-expressing cells. We hypothesized that cardiac glycoside drugs might block the binding reaction between ACE2 and the Spike (S) protein, and thus block viral penetration into target cells. To test this hypothesis we developed a biochemical assay for ACE2:Spike binding, and tested cardiac glycosides as inhibitors of binding. Here we report that ouabain, digitoxin, and digoxin, as well as sugar-free derivatives digitoxigenin and digoxigenin, are high-affinity competitive inhibitors of ACE2 binding to the Original [D614] S1 and the α/β/γ [D614G] S1 proteins. These drugs also inhibit ACE2 binding to the Original RBD, as well as to RBD proteins containing the β [E484K], Mink [Y453F] and α/β/γ [N501Y] mutations. As hypothesized, we also found that ouabain, digitoxin and digoxin blocked penetration by SARS-CoV-2 Spike-pseudotyped virus into human lung cells, and infectivity by native SARS-CoV-2. These data indicate that cardiac glycosides may block viral penetration into the target cell by first inhibiting ACE2:RBD binding. Clinical concentrations of ouabain and digitoxin are relatively safe for short term use for subjects with normal hearts. It has therefore not escaped our attention that these common cardiac medications could be deployed worldwide as inexpensive repurposed drugs for anti-COVID-19 therapy.
Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis
Authors: Køster Ditte , Egedal Johanne Hovgaard , Lomholt Søren , Hvid Malene , Jakobsen Martin R. , Müller-Ladner Ulf , Eibel Hermann , Deleuran Bent , Kragstrup Tue Wenzel , Neumann Elena , Nielsen Morten Aagaard
Published: November 2021

Fibroblast-like synoviocytes (FLS) play an important pathological role in persistent inflammatory joint diseases such as rheumatoid arthritis (RA). These cells have primarily been characterized in the RA synovial membrane. Here we aim to phenotypically and functionally characterize cultured synovial fluid-derived FLS (sfRA-FLS). Paired peripheral blood mononuclear cells (PBMC) and sfRA-FLS from patients with RA were obtained and monocultures of sfRA-FLS and autologous co-cultures of sfRA-FLS and PBMC were established. The in situ activated sfRA-FLS were CD34-, CD45-, Podoplanin+, Thymocyte differentiation antigen-1+. SfRA-FLS expressed uniform levels of NFкB-related pathway proteins and secreted several pro-inflammatory cytokines dominated by IL-6 and MCP-1. In a co-culture model with autologous PBMC, the ICAM-1 and HLA-DR expression on sfRA-FLS and secretion of IL-1β, IL-6, and MCP-1 increased. In vivo, human sfRA-FLS were cartilage invasive both at ipsilateral and contralateral implantation site. We conclude that, sfRA-FLS closely resemble the pathological sublining layer FLS subset in terms of surface protein expression, cytokine production and leukocyte cross-talk potential. Further, sfRA-FLS are comparable to tissue-derived FLS in their capabilities to invade cartilage at implantation sites but also spread tissue destruction to a distant site. Collectively, sfRA-FLS can serve as a an easy-to-obtain source of pathological sublining FLS in RA.
The epicardial delivery of cardiosphere derived cells or their extracellular vesicles is safe but of limited value in experimental infarction
Authors: Crisóstomo Verónica , Baéz-Diaz Claudia , Blanco-Blázquez Virginia , Álvarez Verónica , López-Nieto Esther , Maestre Juan , Bayes-Genis Antoni , Gálvez-Montón Carolina , Casado Javier G. , Sánchez-Margallo Francisco M.
Published: November 2021

The epicardial administration of therapeutics via the pericardial sac offers an attractive route, since it is minimally invasive and carries no risks of coronary embolization. The aim of this study was to assess viability, safety and effectiveness of cardiosphere-derived cells (CDCs), their extracellular vesicles (EVs) or placebo administered via a mini-thoracotomy 72 h after experimental infarction in swine. The epicardial administration was completed successfully in all cases in a surgery time (knife-to-skin) below 30 min. No significant differences between groups were found in cardiac function parameters evaluated using magnetic resonance imaging before therapy and at the end of the study, despite a trend towards improved function in CDC-treated animals. Moreover, infarct size at 10 weeks was smaller in treated animals, albeit not significantly. Arrhythmia inducibility did not differ between groups. Pathological examination showed no differences, nor were there any pericardial adhesions evidenced in any case 10 weeks after surgery. These results show that the epicardial delivery of CDCs or their EVs is safe and technically easy 3 days after experimental myocardial infarction in swine, but it does not appear to have any beneficial effect on cardiac function. Our results do not support clinical translation of these therapies as implemented in this work.
11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma
Authors: Chen Miao , Zhu Wenjia , Du Jianhua , Yang Chen , Han Bing , Zhou Daobin , Huo Li , Zhuang Junling
Published: November 2021

The optimal method of tumor burden evaluation in newly diagnosed multiple myeloma (NDMM) is yet to be determined. This study aimed to compare the value of11C-acetate positron-emission tomography (PET)/computed tomography (CT) (AC-PET and18F-fluorodeoxyglucose PET/CT (FDG-PET) in the assessment of tumor burden in NDMM. This study evaluated 64 NDMM patients between February 2015 and July 2018. AC-PET and FDG-PET were used to assess myeloma lesions. The clinical data, imaging results, and their correlations were analyzed. Diffuse bone marrow uptake in AC-PET was significantly correlated with biomarkers for tumor burden, including serum hemoglobin (P = 0.020), M protein (P = 0.054), the percentage of bone marrow plasma cells (P < 0.001), and the Durie–Salmon stage of the disease (P = 0.007). The maximum standard uptake value (SUVmax) of focal lesions and high diffuse bone marrow uptake in AC-PET showed stronger correlations with high-risk disease (P = 0.017,P = 0.013) than those in FDG-PET. Moreover, the presence of diffuse bone marrow uptake, more than ten focal lesions, and an SUVmaxof focal lesions of > 6.0 in AC-PET, but not in FDG-PET, predicted a higher probability of disease progression and shorter progression-free survival (P < 0.05). AC-PET outperformed FDG-PET in tumor burden evaluation and disease progression prediction in NDMM.
Electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation
Authors: Klaus Jana , Schutter Dennis J. L. G.
Published: November 2021

Transcranial direct current stimulation (tDCS) is an increasingly popular tool to investigate the involvement of the cerebellum in a variety of brain functions and pathologies. However, heterogeneity and small effect sizes remain a common issue. One potential cause may be interindividual variability of the electric fields induced by tDCS. Here, we compared electric field distributions and directions between two conventionally used electrode montages (i.e., one placing the return electrode over the ipsilateral buccinator muscle and one placing the return electrode [25 and 35 cm2 surface area, respectively] over the contralateral supraorbital area; Experiment 1) and six alternative montages (electrode size: 9 cm2; Experiment 2) targeting the right posterior cerebellar hemisphere at 2 mA. Interindividual and montage differences in the achieved maximum field strength, focality, and direction of current flow were evaluated in 20 head models and the effects of individual differences in scalp–cortex distance were examined. Results showed that while maximum field strength was comparable for all montages, focality was substantially improved for the alternative montages over inferior occipital positions. Our findings suggest that compared to several conventional montages extracerebellar electric fields are significantly reduced by placing smaller electrodes in closer vicinity of the targeted area.
Interferon mediated prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine lacking non-structural protein 1
Authors: Rathnasinghe Raveen , Salvatore Mirella , Zheng Hongyong , Jangra Sonia , Kehrer Thomas , Mena Ignacio , Schotsaert Michael , Muster Thomas , Palese Peter , García-Sastre Adolfo
Published: November 2021

The influenza A non-structural protein 1 (NS1) is known for its ability to hinder the synthesis of type I interferon (IFN) during viral infection. Influenza viruses lacking NS1 (ΔNS1) are under clinical development as live attenuated human influenza virus vaccines and induce potent influenza virus-specific humoral and cellular adaptive immune responses. Attenuation of ΔNS1 influenza viruses is due to their high IFN inducing properties, that limit their replication in vivo. This study demonstrates that pre-treatment with a ΔNS1 virus results in an antiviral state which prevents subsequent replication of homologous and heterologous viruses, preventing disease from virus respiratory pathogens, including SARS-CoV-2. Our studies suggest that ΔNS1 influenza viruses could be used for the prophylaxis of influenza, SARS-CoV-2 and other human respiratory viral infections, and that an influenza virus vaccine based on ΔNS1 live attenuated viruses would confer broad protection against influenza virus infection from the moment of administration, first by non-specific innate immune induction, followed by specific adaptive immunity.
Mobile devices and wearable technology for measuring patient outcomes after surgery: a systematic review
Authors: Knight Stephen R. , Ng Nathan , Tsanas Athanasios , Mclean Kenneth , Pagliari Claudia , Harrison Ewen M.
Published: November 2021

Complications following surgery are common and frequently occur the following discharge. Mobile and wearable digital health interventions (DHI) provide an opportunity to monitor and support patients during their postoperative recovery. Lack of high-quality evidence is often cited as a barrier to DHI implementation. This review captures and appraises the current use, evidence base and reporting quality of mobile and wearable DHI following surgery. Keyword searches were performed within Embase, Cochrane Library, Web of Science and WHO Global Index Medicus databases, together with clinical trial registries and Google scholar. Studies involving patients undergoing any surgery requiring skin incision where postoperative outcomes were measured using a DHI following hospital discharge were included, with DHI defined as mobile and wireless technologies for health to improve health system efficiency and health outcomes. Methodological reporting quality was determined using the validated mobile health evidence reporting and assessment (mERA) guidelines. Bias was assessed using the Cochrane Collaboration tool for randomised studies or MINORS depending on study type. Overall, 6969 articles were screened, with 44 articles included. The majority (n = 34) described small prospective study designs, with a high risk of bias demonstrated. Reporting standards were suboptimal across all domains, particularly in relation to data security, prior patient engagement and cost analysis. Despite the potential of DHI to improve postoperative patient care, current progress is severely restricted by limitations in methodological reporting. There is an urgent need to improve reporting for DHI following surgery to identify patient benefit, promote reproducibility and encourage sustainability.
Image-based high-throughput mapping of TGF-β-induced phosphocomplexes at a single-cell level
Authors: Lönn Peter , Al-Amin Rasel A. , Doulabi Ehsan Manouchehri , Heldin Johan , Gallini Radiosa , Björkesten Johan , Oelrich Johan , Kamali-Moghaddam Masood , Landegren Ulf
Published: November 2021

Protein interactions and posttranslational modifications orchestrate cellular responses to e.g. cytokines and drugs, but it has been difficult to monitor these dynamic events in high-throughput. Here, we describe a semi-automated system for large-scale in situ proximity ligation assays (isPLA), combining isPLA in microtiter wells with automated microscopy and computer-based image analysis. Phosphorylations and interactions are digitally recorded along with subcellular morphological features. We investigated TGF-β-responsive Smad2 linker phosphorylations and complex formations over time and across millions of individual cells, and we relate these events to cell cycle progression and local cell crowding via measurements of DNA content and nuclear size of individual cells, and of their relative positions. We illustrate the suitability of this protocol to screen for drug effects using phosphatase inhibitors. Our approach expands the scope for image-based single cell analyses by combining observations of protein interactions and modifications with morphological details of individual cells at high throughput.
Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration
Authors: McKellar David W. , Walter Lauren D. , Song Leo T. , Mantri Madhav , Wang Michael F. Z. , De Vlaminck Iwijn , Cosgrove Benjamin D.
Published: November 2021

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been hampered by the poor sampling of rare and transient cell states that are critical for muscle repair, and do not inform the spatial context that is important for myogenic differentiation. Here, we demonstrate how large-scale integration of single-cell and spatial transcriptomic data can overcome these limitations. We created a single-cell transcriptomic dataset of mouse skeletal muscle by integration, consensus annotation, and analysis of 23 newly collected scRNAseq datasets and 88 publicly available single-cell (scRNAseq) and single-nucleus (snRNAseq) RNA-sequencing datasets. The resulting dataset includes more than 365,000 cells and spans a wide range of ages, injury, and repair conditions. Together, these data enabled identification of the predominant cell types in skeletal muscle, and resolved cell subtypes, including endothelial subtypes distinguished by vessel-type of origin, fibro-adipogenic progenitors defined by functional roles, and many distinct immune populations. The representation of different experimental conditions and the depth of transcriptome coverage enabled robust profiling of sparsely expressed genes. We built a densely sampled transcriptomic model of myogenesis, from stem cell quiescence to myofiber maturation, and identified rare, transitional states of progenitor commitment and fusion that are poorly represented in individual datasets. We performed spatial RNA sequencing of mouse muscle at three time points after injury and used the integrated dataset as a reference to achieve a high-resolution, local deconvolution of cell subtypes. We also used the integrated dataset to explore ligand-receptor co-expression patterns and identify dynamic cell-cell interactions in muscle injury response. We provide a public web tool to enable interactive exploration and visualization of the data. Our work supports the utility of large-scale integration of single-cell transcriptomic data as a tool for biological discovery.
G protein-coupled estrogen receptor stimulates human trophoblast cell invasion via YAP-mediated ANGPTL4 expression
Authors: Cheng Jung-Chien , Fang Lanlan , Li Yuxi , Thakur Avinash , Hoodless Pamela A. , Guo Yanjie , Wang Zhen , Wu Ze , Yan Yang , Jia Qiongqiong , Gao Yibo , Han Xiaoyu , Yu Yiping , Sun Ying-Pu
Published: November 2021

Insufficient invasion of trophoblast cells into the uterine decidua is associated with preeclampsia (PE). G protein-coupled estrogen receptor (GPER) is a membrane estrogen receptor involved in non-genomic estrogen signaling. GPER is expressed in human trophoblast cells and downregulated GPER levels are noted in PE. However, to date, the role of GPER in trophoblast cells remains largely unknown. Here, we applied RNA sequencing (RNA-seq) to HTR-8/SVneo human trophoblast cells in response to G1, an agonist of GPER, and identified angiopoietin-like 4 (ANGPTL4) as a target gene of GPER. Treatment of trophoblast cells with G1 or 17β-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner. Using pharmacological inhibitors as well as loss- and gain-of-function approaches, our results revealed that YAP activation was required for GPER-stimulated ANGPTL4 expression. Transwell invasion assays demonstrated that activation of GPER-induced ANGPTL4 promoted cell invasion. In addition, the expression levels of GPER, YAP, and ANGPTL4 were downregulated in the placenta of patients with PE. Our findings reveal a mechanism by which GPER exerts its stimulatory effect on human trophoblast cell invasion by upregulating YAP-mediated ANGPTL4 expression.
IR-808 loaded nanoethosomes for aggregation-enhanced synergistic transdermal photodynamic/photothermal treatment of hypertrophic scars
Authors: Yu Zhixi , Meng Xinxian , Zhang Shunuo , Wang Xiaodian , Chen Yunsheng , Min Peiru , Zhang Zheng , Zhang Yixin
Published: November 2021

Nanophotosensitizer IR-808-ES is prepared for the PDT/PTT of HSs with the structure of IR-808 aggregating in the ES membrane. IR-808-ES integrates transdermal delivery and the aggregation-enhanced PDT/PTT effect, which enhances the PDT/PTT efficiency for HSs.
2D Salphen-based heteropore covalent organic frameworks for highly efficient electrocatalytic water oxidation
Authors: Wang Lin-Lin , Zhang Wen-Da , Li Tao , Yan Xiaodong , Gao Jie , Chen Yu-Xuan , Shi Ya-Xiang , Gu Zhi-Guo
Published: November 2021

A series of 2D covalent organic frameworks with hexagonal and quadrilateral pores were constructed via in situ salphen or metal salphen formation.
Asymmetric synthesis of dihydrocarbazoles through a Friedel–Crafts alkylation/annulation sequential reaction of indoles
Authors: Hu Linfeng , Cao Weidi , Wang Kaixuan , Liu Xiaohua , Feng Xiaoming
Published: November 2021

An enantioselective Friedel–Crafts alkylation/annulation sequential reaction of indoles or pyrroles with diazoacetoacetate enones was realized, affording a range of optically active dihydrocarbazoles and dihydroindoles.
2D amorphous bi-metallic NiFe nitrides for a high-efficiency oxygen evolution reaction
Authors: Xu Yifan , Cheng Zhenfeng , Jiang Jingyun , Du Jiang , Xu Qun
Published: November 2021

2D amorphous NiFe–N are synthesized in the designed ternary deep eutectic solvents and achieve superior oxygen evolution performance in alkaline media.
A facile design of thio-perylenediimides with controllable fluorescent, photodynamic and photothermal effects towards cancer theranostics
Authors: Liu Chang , Ji Chendong , Fan Zongyang , Ma Ruihao , Yin Meizhen
Published: November 2021

A series of thionated perylenediimides with controllable fluorescent, photodynamic and photothermal effects have been synthesized by a one-pot method for multiple cancer phototheranostics.
Emergence of practical fluorescence in a confined space of nanoporous silica: significantly enhanced quantum yields of a conjugated molecule
Authors: Hayashi Kosei , Fujimaki Yasuto , Mishiba Kentaro , Watanabe Hiroto , Imai Hiroaki
Published: November 2021

The fluorescence of benzanthrone, which is a conjugated molecule bearing a carbonyl group, is activated by confinement in a pore with a diameter close to the molecular size.
VO2(B)@carbon fiber sheet as a binder-free flexible cathode for aqueous Zn-ion batteries
Authors: Li Xiaofan , Yang Linyu , Mi Hongyu , Li Huizhong , Zhang Min , Abliz Ablat , Zhao Fengjun , Wang Shuying , Li Haibing
Published: November 2021

A flexible VO2(B)@CFS electrode exhibits a high capacity and a long cycle life for zinc-ion batteries.
Pair of chiral molecular ladders and successive hydration in single-crystal-to-single-crystal mode
Authors: Park Junmyeong , Kim Dongwon , Kim Dongwook , Jung Ok-Sang
Published: November 2021

Self-assembly of Zn(NO3)2 with a pair of new tridentate chiral Ls produced a pair of chiral ladder-type 1D coordination polymers, where crystals were transformed into different hydrated products of zigzag 1Ds depending on chirality in the SCSC mode.
Potential energy profile for the Cl + (H2O)3 → HCl + (H2O)2OH reaction. A CCSD(T) study
Authors: Li Guoliang , Yao Ying , Lü Shengyao , Xie Yaoming , Douberly Gary E. , Schaefer Henry F.
Published: November 2021

The Cl + (H2O)3 → HCl + (H2O)2OH reaction has been investigated using the CCSD(T) method with correlation consistent basis sets up to cc-pVQZ. The Cl + (H2O)3 reaction is also compared with related Cl + H2O, Cl + (H2O)2 and F + (H2O)3 reactions.
Mechanistic insight into construction of axially chiral biaryls via palladium/chiral norbornene cooperative catalysis: a DFT-based computational study
Authors: Ma Xuexiang , Feng Aili , Liu Chengbu , Zhang Dongju
Published: November 2021

DFT calculations rationalize the enantioselectivity and clarify the reaction sequence of two aryl halides as well as the substantial role of the ortho-ester group in the aryl bromide.
Constructing Cu2O/Bi2MoO6 p–n heterojunction towards boosted photo-assisted-electro-Fenton-like synergy degradation of ciprofloxacin
Authors: Wang Jiaojiao , Jia Xiaoqing , Shang Denghui , Xie Liangbo , Li Yi , Zhang He , Zhan Sihui , Hu Wenping
Published: November 2021

Herein, a photo-assisted-electro-Fenton-like (PAEF-like) system using p–n type Cu2O/Bi2MoO6 (CBM) as photoelectric catalyst was designed for efficient ciprofloxacin removal.
A stand-alone cobalt bis(dicarbollide) photoredox catalyst epoxidates alkenes in water at extremely low catalyst load
Authors: Guerrero Isabel , Viñas Clara , Romero Isabel , Teixidor Francesc
Published: November 2021

Cobaltabis(dicarbollide), Na[3,3′-Co(η5-1,2-C2B9H11)2] Na[1]), is an efficient photoredox catalyst for the epoxidation of alkenes in water, at low catalyst loading and requiring short reaction times (15–30 min).
Water solubilization of paclitaxel using polypeptides for cancer therapy
Authors: Kawasaki Riku , Kawamura Shogo , Hino Shodai , Yamana Keita , Ikeda Atsushi
Published: November 2021

A water solubilization technique using biocompatible polypeptides via a mechanochemical approach was developed for the issues in the pharmaceutical industry.
High CO2 separation performance on a metal–organic framework composed of nano-cages lined with an ultra-high density of dual-side open metal sites
Authors: Li Liangjun , He Jiangxiu , Xu Wenli , Zhang Kuitong , Xing Tao , Li Zhi , Zhen Dewen , Xiong Bo , Ge Zhixing , Zhang Xi , Wang Shanyu , Zhang Fuzhao , Gu Xin , Dai Pengcheng , Liu Dandan , Yang Lingzhi , Zhao Xuebo
Published: November 2021

High CO2 separation performance on a microporous MOF incorporting nano-cages and an ultra-high density of dual-side open metal sites is reported.
Recent advances of metal telluride anodes for high-performance lithium/sodium–ion batteries
Authors: Fan Huilin , Mao Pengcheng , Sun Hongyu , Wang Yuan , Mofarah Sajjad S. , Koshy Pramod , Arandiyan Hamidreza , Wang Zhiyuan , Liu Yanguo , Shao Zongping
Published: November 2021

Recent advances of metal telluride anodes for high-performance lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs), which is important electrochemical energy storage technologies with high energy density and environmental benignity.
Self-assembly and boosted photodegradation properties of perylene diimide via different solvents
Authors: Yang Ruizhe , Liu Jinyuan , Wang Bin , Wang Rong , Song Yanhua , Hua Yingjie , Wang Chongtai , She Yuanbin , Yuan Junjie , Xu Hui , Li Huaming
Published: November 2021

Through different solvents, the self-assembly process of monomer PDI was studied. The rapid separation and transfer of the photogenerated carriers and π–π interaction between self-assembled PDI together boost the photocatalytic degradation reaction.
Cysteine residue-bridged dinuclear Ni–Fe complexes related to [NiFe]-H2ases
Authors: Song Li-Cheng , Zhang Zhen-Qing , Gu Zhen-Chao , Jiang Kai-Yu
Published: November 2021

Cysteine residue-containing [NiFe]-H2ase models 1–6 have been prepared for the first time and some of them were found to be catalysts for H2production from HOAc under CV conditions.
Morphological transitions in chemically fueled self-assembly
Authors: Dai Kun , Tena-Solsona Marta , Rodon Fores Jennifer , Bergmann Alexander M. , Boekhoven Job
Published: November 2021

This work demonstrates the importance of considering the disassembly pathway when designing new chemically fueled self-assembling systems.
Durable and recyclable conjugated microporous polymer mediated controlled radical polymerization under white LED light irradiation
Authors: Xiao Longqiang , Li Qiuyu , Liu Yabin , Fu Xiaoling , Zhao Yulai , Cai Jingyu , Yin Xiangyu , Hou Linxi
Published: November 2021

In this work, we report the first example of the use of a conjugated microporous polymer material (EI-CMP) as a heterogeneous catalyst in reversible complexation-mediated radical polymerization under white LED light irradiation.
The modification effect of Fe2O3 nanoparticles on ZnO nanorods improves the adsorption and detection capabilities of TEA
Authors: Liang Xiao , Zhang Jing , Zhang Kewei , Yang Xiaodong , Zhang Mingzhe
Published: November 2021

The depletion layer and more active sites are the key factors for improving the gas sensitivity of an Fe2O3/ZnO sensor.
Gold-catalysed synthesis of phosphonate-substituted oxetan-3-ones – an easy access to highly strained HWE reagents
Authors: Tahir Shaista , Wunsch Jonas F. , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K.
Published: November 2021

Gold-catalysed reaction of alkynyl phosphonates to attain alkenyl substituted oxetan-3-ones via subsequent HWE reaction.
Additive manufacturing technology of polymeric materials for customized products: recent developments and future prospective
Authors: Pal Akhilesh Kumar , Mohanty Amar K. , Misra Manjusri
Published: November 2021

The worldwide demand for additive manufacturing (AM) is increasing due to its ability to produce more challenging customized objects based on the process parameters for engineering applications.
Effects of inorganic particles on the crystallization, mechanical properties and cellular structure of foamed PP composites in the IMD/MIM process
Authors: Fan Tao , Zhao Qianqian , Guo Wei , Mao Huajie , He Bo , Ruan Wei
Published: November 2021

As the particle size decreased, the relative amount of β-crystal and mechanical properties increased, while the thickness of the core layer gradually decreased.
Synthesis of Cu3P/SnO2 composites for degradation of tetracycline hydrochloride in wastewater
Authors: Shi Huancong , Zheng Tao , Zuo Yuanhui , Wu Qiming , Zhang Yun , Fan Yi , Tontiwachwuthikul Paitoon
Published: November 2021

Cu3P@SnO2 was synthesized with Cu3P nanoparticles loaded on the surface of hollow SnO2 microspheres via a simple annealing process.
Rapid structural discrimination of IgG antibodies by multicharge-state collision-induced unfolding
Authors: Yin Zhibin , Du Mingyi , Chen Dong , Zhang Wenyang , Huang Wenjie , Wu Xinzhou , Yan Shijuan
Published: November 2021

A simplified multicharge-state collision-induced unfolding (CIU) method was proposed for rapid differentiation of IgG isotypes that differ in terms of the numbers and patterns of disulfide bonds.
Measuring integrated understanding of undergraduate chemistry research experiences: assessing oral and written research artifacts
Authors: Helix Max R. , Coté Laleh E. , Stachl Christiane N. , Linn Marcia C. , Stone Elisa M. , Baranger Anne M.
Published: November 2021

Understanding the impact of undergraduate research experiences (UREs) and course-based undergraduate research experiences (CUREs) is crucial as universities debate the value of allocating scarce resources to these activities. We report on the Berkeley Undergraduate Research Evaluation Tools (BURET), designed to assess the learning outcomes of UREs and CUREs in chemistry and other sciences. To validate the tools, we administered BURET to 70 undergraduate students in the College of Chemistry and 19 students from other STEM fields, comparing the performance of students who had less than one year of undergraduate research to those with more than one year of research experience. Students wrote reflections and responded to interviews during poster presentations of their research project. BURET asks students to communicate the significance of their project, analyze their experimental design, interpret their data, and propose future research. Scoring rubrics reward students for integrating disciplinary evidence into their narratives. We found that the instruments yielded reliable scores, and the results clarified the impacts of undergraduate research, specifically characterizing the strengths and weaknesses of undergraduate researchers in chemistry at our institution. Students with at least a year of research experience were able to use disciplinary evidence more effectively than those with less than one year of experience. First-year students excelled at explaining the societal relevance of their work, but they incorporated only minimal discussion of prior research into their reflections and presentations. Students at all levels struggled to critique their own experimental design. These results have important implications for undergraduate learning, suggesting areas for faculty members, graduate student research mentors, and CURE or URE programs to improve undergraduate research experiences.
Facile engineering of ECM-mimetic injectable dual crosslinking hydrogels with excellent mechanical resilience, tissue adhesion, and biocompatibility
Authors: Fu Han , Yu Chenggong , Li Xiaodi , Bao Hongying , Zhang Bo , Chen Zhongjin , Zhang Zhijun
Published: November 2021

A simple method for developing natural biopolymer-based injectable hydrogels through primary dynamic bonding and secondary covalent crosslinking.
ICG@ZIF-8/PDA/Ag composites as chemo-photothermal antibacterial agents for efficient sterilization and enhanced wound disinfection
Authors: Hui Shuhan , Liu Qiqi , Han Yandong , Zhang Lijuan , Yang Jun , Jiang Shan , Qian Haisheng , Yang Wensheng
Published: November 2021

This work reports a novel ZIF-8 based composite that integrates photothermal agents (ICG and PDA) and metal ions (Ag and Zn) into one single system to achieve effective chemo-photothermal combinational wound disinfection.
Recent advances on metal oxide-based luminescence thermometry
Authors: Jahanbazi Forough , Mao Yuanbing
Published: November 2021

Luminescence thermometry alleviates the difficulties associated with conventional methods for thermal sensing and provides outstanding opportunities for non-contact thermometry with high sensitivity and resolution.
Controllable sign reversal of Seebeck coefficient and the large tunability of ZT value of plumbene: a first-principles study
Authors: Zhang Binyuan , Guo Fei , Zhang Lei , Zhu Mingfeng , Zheng Yisong
Published: November 2021

When the Fermi level is shifted to the nearby van Hove singularity by electron doping from its intrinsic position, the ZT value (figure of merit) of the high-buckled plumbene at 100 K is increased by about 250 times.
Aluminum-ion-intercalation nickel oxide thin films for high-performance electrochromic energy storage devices
Authors: Zhang Hongliang , Liu Sheng , Xu Tao , Xie Weiping , Chen Guoxin , Liang Lingyan , Gao Junhua , Cao Hongtao
Published: November 2021

Unleashing the true merits of aluminum-ion-intercalation nickel oxide thin films for EESDs by taking a closer look at the optical modulation, energy storage, and diffusion and reaction kinetics of the NiO/Al3+ system.
Blue/red ratiometric pH sensors without background signals based on 808 nm-excited core–triple shell up-conversion nanoparticles
Authors: Wang Tao , Sun Fenglei , Jiang Zike , Wang Jing , Ma Yanyan , Lin Haitao , Lv Hongmin , Xu Shanshan , Li Jinhua , Zhou Guangjun
Published: November 2021

A pH sensor based on CTS UCNPs exhibits ratiometric responses from pH 4 to 7 according to blue/red luminescence intensity ratios under 808 nm excitation.
On the crystal structure thermal evolution of formamidinium lead tribromide, CH(NH2)2PbBr3
Authors: Abia Carmen , López Carlos Alberto , Álvarez-Galván María Consuelo , Canadillas-Delgado Laura , Fernández-Díaz María Teresa , Alonso José Antonio
Published: November 2021

A structural study from synchrotron X-ray and neutron diffraction of an undeuterated FAPbBr3 specimen allows identification of two phase transitions (Pm3̄m→P4/mbm→Pnma). Further rearrangements in the H bonds to Br imply thermal events observed by calorimetric measurements.
Using Nominal Group Technique to Identify Key Ethical Concerns Regarding Hearing Aids With Machine Learning
Authors: Naudé Alida , Bornman Juan
Published: November 2021

Purpose:

Machine learning (ML) in new-generation hearing aid technology presents a beneficial opportunity for development in audiology. It is, however, important to balance new applications against the audiologist's professional ethics to protect the client from any harm. This study aimed to identify the key ethical concerns related to the latest digital hearing aid technology that incorporates ML that could potentially impact the client and/or the audiologist.

Method:

A nominal group technique was conducted with the audiologist to generate and prioritize a list of key ethical concerns related to human data interaction, with specific focus on hearing aids.

Results:

Five categories were identified in relation to the potential impact on the client: (a) privacy and confidentiality, (b) relationship and trust, (c) nonmaleficence, (d) informed decision making, and (e) financial gain. An additional five categories were identified in relation to the potential impact on the audiologist: (a) privacy and confidentiality, (b) professional responsibility, (c) relationship and trust, (d) financial gain, and (e) trust technology. Privacy and confidentiality were ranked as the highest priority that should be considered when supplying clients with the latest hearing aid technology.

Conclusions:

Hearing aid technology has evolved considerably, and audiologists need to keep abreast of and master the general technological developments and the associated ethical challenges that may arise. Discussions on the ethics related to ML and hearing aid fittings will help identify the key ethical concerns involved and, thereby, enhance the ethical sensitivity of the profession.
Beyond Services in the United States of America: Fulbright U.S. Scholar Experience in Vietnam
Authors: Lee Sue Ann S.
Published: November 2021

Purpose:

This article addresses my experience as a speech-language pathologist in a cultural exchange and global outreach program in Vietnam. The importance and various types of cultural exchange and global outreach programs available through the U.S. Department of State, the current status of educational speech-language pathology programs in Vietnam, and a brief introduction of the country as well as its unique cultural characteristics are also discussed.

Conclusions:

As a Fulbright U.S. scholar, I resided 6 months in Hue, Vietnam, to provide education and consultation services to children who needed speech-language pathology services and their families. The speech pathology profession in Vietnam is significantly underdeveloped. However, several international nongovernmental organizations and foreign universities have assisted Vietnam in developing speech pathology and audiology professions. Among many opportunities to serve the needs of speech pathology and audiology preprofessional education and service delivery in Vietnam, one of the most prestigious opportunities is the Fulbright U.S. Scholar Program. It is my hope that my personal and professional experiences can encourage fellow speech-language pathology and audiology professors and practitioners to apply for a Fulbright scholarship to pursue a rich volunteer experience in a foreign country as well as to improve their cultural competency upon return to their own academic institutions.
Fast‐Tracker 2.0: Improving autonomy of aerial tracking with active vision and human location regression
Authors: Pan Neng , Zhang Ruibin , Yang Tiankai , Cui Can , Xu Chao , Gao Fei
Published: November 2021

In recent years, several progressive studies promote the development of aerial tracking. One of the representative studies is our previous work Fast‐Tracker which is applicable to various challenging tracking scenarios. However, it suffers from two main drawbacks: (1) the oversimplification in target detection by using artificial markers and (2) the contradiction between simultaneous target and environment perception with limited onboard vision. In this study, we upgrade the target detection in Fast‐Tracker to detect and localise a human target based on deep learning and non‐linear regression to solve the former problem. For the latter one, we equip the quadrotor system with 360° active vision on a customised gimbal camera. Furthermore, we improve the tracking trajectory planning in Fast‐Tracker by incorporating an occlusion‐aware mechanism that generates observable tracking trajectories. Comprehensive real‐world tests confirm the proposed system's robustness and real‐time capability. Benchmark comparisons with Fast‐Tracker validate that the proposed system presents better tracking performance even when performing more difficult tracking tasks. The cover image is based on the Original Article Fast‐Tracker 2.0: Improving autonomy of aerial tracking with active vision and human location regression by Can Cui et al., https://doi.org/10.1049/csy2.12033.
Impedance modelling and grid integration stability evaluation of three‐phase virtual synchronous generator
Authors: Chen Jie , Zhang Xinying , Yang Yiqian , Chen Jiawei , Chen Xin
Published: November 2021

Virtual synchronous generator (VSG), which can behave with analogous characteristics as the conventional synchronous generator (SG) and provide voltage and inertia/damping support, is universally regarded as a grid‐friendly interface. Here, the comprehensive sequence‐impedance model of the VSG is developed by using the harmonic linearization method. To improve the accuracy of impedance model, the influences of the reactive power loop (RPL) and mirror frequency effect (MFE) are discussed and evaluated for the first time. Three different impedance models of the VSG (conventional, considering RPL, and considering both MFE and RPL) are derived and compared in detail. Besides, the synchronous frequency resonance (SFR) issue and grid‐interactive oscillation risk of the VSG are also investigated. The results indicate that the VSG may suffer from power oscillation when the integral coefficient of RPL is too large, but has excellent robustness and stability when connected to weak grid. This feature makes it more appealing in weak grid integration. Finally, the validity of the theoretical analysis is verified by simulations and experiments.
Analysis of collaborative wireless vehicular technologies under realistic conditions
Authors: Tahir Muhammad Naeem , Katz Marcos , Rashid Urooj
Published: November 2021

Reliable communications are essential to provide intelligent services to connected cars. For operational services, connected vehicles in VANET (Vehicle Ad hoc Networks) regularly transfer large amounts of data related to vehicular safety. Similarly, V2X (Vehicle‐to‐Everything) communications include vehicles exchanging information with each other and with infrastructure that is, Vehicle‐to‐Infrastructure (V2I) and Vehicle‐to‐Vehicle (V2V). This paper has analyzed the performance of IEEE 802.11p and 5G test network in a collaborative manner under realistic conditions. For performance analysis the exchange of safety‐critical road weather and traffic information has been performed to enhance the traffic safety and traffic efficiency in the domain of intelligent transportation system (ITS). The vehicular connectivity is provided in V2V and V2I scenarios by utilizing short‐range IEEE 802.11 standard or cellular approaches, such as the 5G network. Here, we consider combining these technologies in a cooperative manner to exploit jointly their advantages. In this cooperative heterogeneous network, the IEEE 802.11p supports safety‐related pilot use cases while the provision of non‐safety‐related pilot use cases are supported by the 5G test network. The performance analysis revealed that the IEEE 802.11p performs quite reasonably well with restricted mobility in contrast of 5G test network in a collaborative manner to avoid road accidents.
Rheumatologie 2021
Authors: Aringer Martin , Rehart Stefan
Published: November 2021

Die Fortschritte der Rheumatologie haben aus fast regelhaft zu Invalidität und frühem Tod führenden chronischen entzündlich-rheumatischen Erkrankungen gut behandelbare Krankheitsbilder gemacht. Dieser Fortschritt bringt aber auch ein paar Herausforderungen mit sich. Diese CME-Arbeit fasst den aktuellen Stand der Rheumatologie prägnant und anhand der wesentlichen Erkrankungsbilder zusammen und beleuchtet ihre Schnittstellen.
Transpancreatic precut papillotomy versus double-guidewire technique in difficult biliary cannulation: a systematic review and meta-analysis
Authors: Guzmán-Calderón Edson , Martinez-Moreno Belen , Casellas Juan A. , Aparicio José Ramón
Published: November 2021

Background and study aims Approximately 11 % of biliary cannulations are considered difficult. The double guidewire (DGW-T) and transpancreatic sphincterotomy (TPS) are two useful techniques when difficult cannulation exists and the main pancreatic duct is unintentionally accessed. We carried out a systematic review and meta-analysis to evaluate the effectiveness and security of both DGW-T and TPS techniques in difficult biliary cannulation.

Methods We conducted a systematic review in different databases, such as PubMed, OVID, Medline, and Cochrane Databases. Were included all RCT which showed a comparison between TPS and DGW in difficult biliary cannulation. Endpoints computed were successful cannulation rate, median cannulation time, and adverse events rate.

Results Four studies were selected (4 RCTs). These studies included 260 patients. The mean age was 64.79 ± 12.99 years. Of the patients, 53.6 % were men and 46.4 % were women. The rate of successful cannulation was 93.3 % in the TPS group and 79.4 % in the DGW-T group (P = 0.420). The rate of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) was lower in patients who had undergone TPS than DGW-T (TPS: 8.9 % vs DGW-T: 22.2 %, P = 0.02). The mean cannulation time was 14.7 ± 9.4 min in the TPS group and 15.1 ± 7.4 min with DGW-T (P = 0.349).

Conclusions TPS and DGW are two useful techniques in patients with difficult cannulation. They both have a high rate of successful cannulation; however, the PEP was higher with DGW-T than with TPS.
EndoConf: real-time video consultation during endoscopy; telemedicine in endoscopy at its best
Authors: Deding Ulrik , Høgh Anders , Buch Niels , Koulaouzidis Anastasios , Baatrup Gunnar , Bjørsum-Meyer Thomas
Published: November 2021

Background and study aims The aim of this study was to introduce EndoConf, a reliable and easy-to-use tool capable of optimizing clinical care in endoscopy by reducing the number of repeat endoscopy procedures, providing continuous on-the-job clinical education, and allowing a smooth transition to the next level of artificial intelligence-supported systems.

Patients and methods We prospectively developed and improved a real-time conference system (EndoConf). EndoConf enables endoscopists to contact on-demand and in real time experienced endoscopists across other sites. After the initial introduction period, we registered all EndoConf-assisted procedures from our unit (Surgical Department of Odense University Hospital) over a 3-month period (Autumn of 2019).

Results Of 84 EndoConf-supported procedures, 58 were eligible for further analysis. Eventually, 38 calls were made, of which only four were technically of low quality (10.5 %) while three were not answered (7.9 %). Of the 35 (92.1 %) completed EndoConf calls; 24 were referred for endoscopic mucosal resection, six were referred for transanal microsurgery preceded by transrectal ultrasonography and three were referred for multidisciplinary conference, whereas in two cases, the lesion was resected during EndoConf.

Conclusions We found the EndoConf system to provide support that could reduce the number of unnecessary repeat endoscopic procedures while at the same time ensuring avoidance of any hazardous attempt at polypectomy.