bluuebunny/crossref_metadata_2025 huggingface dataset:
Endotracheal Tobramycin in Gram-Negative Pneumonitis
Authors: Stillwell Paul C. , Kearns Gregory L. , Jacobs Richard F.
Published: May 2016

This report describes the treatment of resistant gram-negative pneumonitis in a compromised host by the combined use of intravenous and endotracheal tobramycin. The endotracheal administration appeared to have an effect on the serum concentration and elimination rate, necessitating a reduction in the amount of drug given intravenously. The only apparent clinical complication of endotracheal drug administration was transient coughing. The addition of endotracheal aminoglycosides to intravenous antibiotics may be useful in pediatric patients with unresponsive (or other difficult-to-treat) pneumonitis caused by resistant microorganisms. The potential contribution of endotracheal aminoglycosides to the serum level and/or disposition profile must be recognized, and therapeutic drug monitoring guided accordingly when this route of administration is used.
Stability and Compatibility of Cimetidine Hydrochloride and Aminophylline in Dextrose 5% in Water Injection
Authors: Baptista Richard J. , Mitrano Francis P.
Published: May 2016

A controlled study was conducted to assess the physical compatibility of cimetidine hydrochloride (HCl) and aminophylline and the chemical stability of an admixture of the two medications in dextrose 5% in water (D5W) injection, over 48 hours at room temperature. Three one-liter admixtures were prepared, each containing cimetidine HCl 1200 mg and aminophylline 500 mg in D5W. One liter of only cimetidine HCl 1200 mg in D5W and one liter of only aminophylline 500 mg in D5W served as controls. Samples drawn from the five admixtures and immediately frozen were analyzed for cimetidine and theophylline content at times 0, 1, 6, 24, and 48 hours using high-performance liquid chromatography. Chemical stability of each drug was assessed relative to its time-zero concentration. Samples were also drawn from each test and control solution at every time interval to assess the pH. Admixtures were stored at room temperature out of direct sunlight for the duration of the study, and were visually inspected for color change, turbidity, cloudiness, and precipitation. Recovery of cimetidine and theophylline at all test intervals, pH assessments, and visual inspections of the admixtures showed that cimetidine HCl and aminophylline are both chemically stable and physically compatible for 48 hours at room temperature in one liter of D5W.
Evaluation of Therapeutic Drug Monitoring in a Long-Term Care Facility: A Pilot Project
Authors: Pucino Frank , Baumgart Peggy J. , Strommen Gordon L. , Silbergleit Inger-Lise , Forbes Dave , Hoag Stephen G. , Beck Carol L. , Tedros Nancy M.
Published: May 2016

The need for a therapeutic drug monitoring service was evaluated in a 150-bed long-term care facility. Thirty blood samples from 28 residents (mean age 87.9 years) were assayed to determine trough drug concentrations. All subjects were examined to determine pharmacodynamic effect. Pharmacokinetic consultations were written for serum drug concentrations outside accepted ranges. Fifty percent (15 of 30) of serum drug levels measured were subtherapeutic; the remaining levels were in the normal therapeutic range. Based on this sample data, it could be concluded that a minimum of 32 percent and as many as 68 percent of serum drug levels would be subtherapeutic following drug analysis in similar nursing home populations. Of 12 consultations, recommendations for seven (58 percent) were accepted by the subject's primary care physicians. Four of the consultations (33 percent) resulted in dosage modifications. These results support the need for further study.
A Study of Patients' Perceived Importance of Medication Information Provided by Physicians in a Health Maintenance Organization
Authors: Gardner Marie E. , Rulien Neil , McGhan William F. , Mead Robert A.
Published: May 2016

A study was done to determine perceived importance of medication information and the kind of information provided to patients in an outpatient setting. A scale describing 14 points of medication information was used prior to the physician's visit in one study phase and afterwards in the second phase. Results showed that patients perceived all 14 items to be important but rated precautions to observe, drug interactions, and adverse effects most highly. Also, less than half the time was information considered highly important by patients provided by their physicians.
Monoamine Oxidase Inhibitors and Weight Gain
Authors: Cantú Thomas G. , Korek Joan S.
Published: May 2016

Weight gain associated with antidepressant therapy is a common problem that often results in noncompliance. Some authors suggest that monoamine oxidase inhibitors (MAOI) are less likely to produce weight gain than tricyclic antidepressants. This paper addresses the relative potential for weight gain with the MAOI. Assessing the potential for antidepressant-induced weight gain necessitates separating the weight changes associated with alterations in mood disorders from those due to drug-induced alterations in appetite control. The mechanisms of appetite control are reviewed briefly followed by proposed mechanisms by which the MAOI may alter this control. A literature review suggests that phenelzine is the MAOI most likely to induce weight gain; reports of isocarboxazid-induced weight gain are less common. There are no cases of tranylcypromine-induced weight gain in the literature that are clearly associated with the drug. The MAOI probably have different effects on the mechanisms of appetite control.
Comparison of Administration of Two Standard Intravenous Amino Acid Formulas to Severely Brain-Injured Patients
Authors: Ott Linda G. , Schmidt Jack J. , Young A. Byron , Twyman Diana L. , Rapp Robert P. , Tibbs Phillip A. , Dempsey Robert J. , McClain Craig J.
Published: May 2016

Twenty severely brain-injured patients with Glasgow Coma Scale scores of 4–9 were prospectively randomized to receive one of two standard amino acid formulas, starting with the first day of hospital admission up to day 14 postinjury. Formula 2 (patient group 2) had 54 percent more leucine, 53 percent more isoleucine, 74 percent more valine, 28 percent less phenylalanine, 31 percent less methionine, 111 percent more proline, 38 percent less alanine, and 38 percent less glycine than formula 1 (patient group 1). Groups 1 and 2 received statistically equal overall mean parenteral nutrition calories and protein (2173 ± 147 vs. 2059 ± 143 kcal, and 77 ± 12 vs. 83.1 ± 6 g, respectively). There was a significant difference in overall mean urinary urea nitrogen excretion (group 1 = 24.6 ± 1.3 vs. group 2= 18.3 ± 1.1, p = 0.02) and nitrogen balance (group 1 = −8.0 ± 2.1 vs. group 2 = + 1.8 ± 1.2, p = 0.01). Mean overall isoleucine values were significantly higher in group 2 (overall mean 77 μmol/L vs. 62 μmol/L, p = 0.04). Phenylalanine levels were significantly higher in group 1 (107 μmol/L) versus group 2 (82 μmol/L) patients (p = 0.01). Arginine levels were significantly higher in group 1 (78 μmol/L) versus group 2 (49 μmol/L) patients (p = 0.0002). This observation suggests that some standard intravenous amino acid formulas may be more apt to promote positive nitrogen balance than others.
Effect of Infusion Rate on Amphotericin B-Associated Febrile Reactions
Authors: Cleary John D. , Weisdorf Daniel , Fletcher Courtney V.
Published: May 2016

Our objective was to prospectively study febrile and chill reactions associated with two amphotericin B (AB) infusion rates, slow (2-hour) versus rapid (45 minute). Seventeen consenting bone marrow transplant recipients in whom AB was to be initiated for documented or suspected fungal infections were recruited. After standardized premedication, patients received eight daily AB infusions (0.5 mg/kg/d, concentration 0.25 mg/ml). Rate was assigned using a randomized, crossover pair design. Axillary temperature, chills, and meperidine dose required to resolve chills were monitored for each infusion. For the first pair of infusions, fever (defined as a rise of 1 °C) occurred frequently, in 12 of 17 (70.5 percent) and 13 of 17 patients (76.4 percent), with a mean rise of 1.7 °C (range 1.1–3.7) and 1.7 °C (1.1–3.5) degrees for the 45-minute and 2-hour infusions, respectively (p > 0.10). Chills were observed in 15 of 17 (88.2 percent) and 14 of 17 (82.3 percent) recipients of the 45-minute and 2-hour infusions, respectively. The time of onset (p > 0.10) and the duration of chills (p = 0.08) were similar for both infusion rates. Meperidine requirements for rapid and slow infusions were similar as well (p = 0.12). These data suggest that for patients free of preexisting renal and cardiac disease, rapid AB infusions are well tolerated and produce adverse reactions (fever and chills) similar in nature and severity to slower infusions.
Development of Pseudomonas Aeruginosa Resistance to Norfloxacin during Therapy
Authors: Rowen Randall C. , Mullenix Timothy A. , Arroyo Julio C. , Voris John C.
Published: May 2016

Two elderly patients diagnosed with Pseudomonas aeruginosa urinary tract infections were treated with oral norfloxacin in the recommended dose of 400 mg q12h. Initially, antimicrobial susceptibility data indicated the organisms were sensitive to norfloxacin. Six to eight days into therapy urine cultures became positive for P. aeruginosa once again; this time, however, susceptibility reports indicated the organisms were now resistant to norfloxacin. Since cross-resistance among norfloxacin, other quinolones, and cephalosporins can occur, we recommend repeated urine cultures during and after norfloxacin therapy in elderly patients with complicated P. aeruginosa urinary tract infections.
Relationship between Drug Use and Urinary Incontinence in Elderly Women
Authors: Shimp Leslie A. , Wells Thelma J. , Brink Carol A. , Diokno Ananias C. , Gillis Grace L.
Published: May 2016

Two hundred older women with urinary incontinence were studied to observe the influence of their prescription and nonprescription drug use on symptoms of incontinence. Ninety percent of women reported using medication, with an average use of four drugs. Medications statistically associated with urinary incontinence symptomatology were prostaglandin inhibitors, diuretics, and estrogen therapy. Further studies are needed to clarify the relationship between medication usage and the presence and severity of urinary incontinence.
A Method for Meta-Analysis of Epidemiological Studies
Authors: Einarson Thomas R. , Leeder J. Steven , Koren Gideon
Published: May 2016

This article presents a stepwise approach for conducting a meta-analysis of epidemiological studies based on proposed guidelines. This systematic method is recommended for practitioners evaluating epidemiological studies in the literature to arrive at an overall quantitative estimate of the impact of a treatment. Bendectin is used as an illustrative example. Meta-analysts should establish a priori the purpose of the analysis and a complete protocol. This protocol should be adhered to, and all steps performed should be recorded in detail. To aid in developing such a protocol, we present methods the researcher can use to perform each of 22 steps in six major areas. The illustrative meta-analysis confirmed previous traditional narrative literature reviews that Bendectin is not related to teratogenic outcomes in humans. The overall summary odds ratio was 1.01 (χ2 = 0.05, p = 0.815) with a 95 percent confidence interval of 0.66–1.55. When the studies were separated according to study type, the summary odds ratio for cohort studies was 0.95 with a 95 percent confidence interval of 0.62–1.45. For case-control studies, the summary odds ratio was 1.27 with a 95 percent confidence interval of 0.83–1.94. The corresponding chi-square values were not statistically significant at the p = 0.05 level.
Carboplatin: A New Cisplatin Analog
Authors: Woloschuk Donna M.M. , Pruemer Jane M. , Cluxton Robert J.
Published: May 2016

Carboplatin, a new antineoplastic agent with a spectrum of antitumor activity similar to cisplatin, has shown appreciable activity in patients with ovarian carcinoma, head and neck cancer, and small-cell lung cancer. This platinum complex is less nephrotoxic, ototoxic, and neurotoxic than cisplatin. Myelosuppression may be severe and dose-limiting. Carboplatin distributes into a volume approximating total body water, and is slowly bound to plasma proteins; its elimination is a biphasic process. Renal clearance of free platinum from carboplatin correlates highly with creatinine clearance in patients with normal or impaired renal function. The recommended iv dose of carboplatin as a single agent in previously untreated patients is 400–500 mg/m2; dosage must be reduced in patients with decreased renal function, low initial platelet count, or extensive prior chemotherapy or radiation therapy. Carboplatin will be most useful in patients with decreased renal function and those who cannot tolerate high-volume hydration regimens. Patients at higher risk for development of cisplatin-related ototoxicity or neurotoxicity (e.g., patients expected to receive cumulative cisplatin doses exceeding 600–800 mg/m2) may be ideal candidates for carboplatin as initial therapy. Large-scale comparative trials are needed before carboplatin can be recommended as a replacement for cisplatin.
Ineffectiveness of Continuous Quinidine Gluconate Infusion in the Treatment of Severe Chloroquine-Resistant Plasmodium Falciparum Malaria
Authors: Matsuura Gary K. , Chan Lucinda A.
Published: May 2016

The drug of choice in the treatment of chloroquine-resistant Plasmodium falciparum malaria is parenteral quinine dihydrochloride. Due to limited use, the drug is not commercially available in the U.S. and must be obtained through the Centers for Disease Control (CDC) in Atlanta, Georgia. As an alternative, the CDC has developed a protocol to treat P. falciparum malaria with parenteral quinidine gluconate. Following this protocol, a 10 mg/kg loading dose of quinidine gluconate followed by a 0.02 mg/kg/min continuous infusion was administered to a 53-year-old man with severe life-threatening chloroquine-resistant P. falciparum malaria. Although the patient described did not survive, the use of parenteral quinidine gluconate still appears to be a viable alternative to parenteral quinine dihydrochloride in the treatment of severe chloroquine-resistant P. falciparum malaria.
High-Dose Lorazepam Therapy for Status Epilepticus in a Pediatric Patient
Authors: Reincke Hanna M. , Gilmore Robin L. , Kuhn Robert J.
Published: May 2016

This report details the management of status epilepticus with high-dose lorazepam in a 14-year-old patient who was receiving oral clonazepam, ethosuximide, and phenobarbital for an intractable seizure disorder. Although respiratory depression is a frequently cited potential complication of therapy, it did not occur in this patient despite an extraordinarily high total dose of lorazepam, possibly because of tolerance associated with benzodiazepine-receptor down-regulation in this patient's chronic clonazepam therapy. Aggressive dosing of a benzodiazepine may be required for patients receiving chronic benzodiazepine therapy.
Fibrin Glue: A Review of its Preparation, Efficacy, and Adverse Effects as a Topical Hemostat
Authors: Thompson Dennis F. , Letassy Nancy A. , Thompson G. Dail
Published: May 2016

Fibrin glue is composed of two separate solutions of fibrinogen and thrombin. When mixed together, these agents mimic the last stages of the clotting cascade to form a fibrin clot. Fibrin glue is available in Europe but is not commercially available in the U.S.; therefore, investigators have extemporaneously compounded their own fibrin glue. Fibrinogen can be obtained from pooled, single-donor, and autologous blood donors and is usually isolated by the process of cryoprecipitation. The thrombin component is generally derived from commercial bovine sources. Some investigators have added calcium chloride and/or antifibrinolytics (i.e., aminocaproic acid, aprotinin) to their preparations. Fibrin glue can be applied using a double-barrel syringe or by spray application. Although fibrin glue has been used in a variety of surgical procedures, it has been especially useful in heparinized patients undergoing cardiovascular procedures requiring extracorporeal circulation, as it does not require an intact hemostatic system to be effective. Fibrin glue also has been evaluated in presealing woven or knitted Dacron vascular grafts. The major drawback to its use is the risk of transmitted serological disease from pooled and single-donor blood donors. The safest preparations use the patient's own blood to prepare fibrin glue. Overall, fibrin glue is a useful adjunct to other methods to control bleeding in selected surgical patients.
Clinically Significant Diuretic-Induced Glucose Intolerance
Authors: Lowder N. Kathryn , Bussey Henry I. , Sugarek Nancy J.
Published: May 2016

Diuretic-induced glucose intolerance is cited frequently as a problem of only limited clinical significance. In certain populations, such as Mexican-Americans, this effect may be much more dramatic. A 50-year-old obese Mexican-American woman presented with a three-month history of increased thirst and frequent urination. A fasting blood glucose concentration of 365 mg/dL prompted initiation of chlorpropamide therapy. A review of her medical history revealed that a thiazide diuretic was started six months previously. A reduction in thiazide dose and potassium supplementation together with chlorpropamide therapy controlled the patient's blood glucose. Subsequently, all three medications were discontinued, and the patient remained normoglycemic during a full year of follow-up. The temporal relationship between symptomatic diabetes and hydrochlorothiazide therapy incriminates the diuretic as the most probable cause.
Possible Interaction of Ranitidine with Phenytoin
Authors: Bramhall Diane , Levine Marc
Published: May 2016

Clinical and animal studies have shown that cimetidine and ranitidine can inhibit hepatic cytochrome P-450-mediated metabolism of a variety of other drugs. This occurs to a lesser extent with ranitidine than with cimetidine at doses commonly used to treat gastric acid-related disorders. We recently observed a 66-year-old man whose steady-state serum phenytoin concentration increased 40 percent during one month after the addition to his regimen of ranitidine 150 mg bid. Because the ranitidine had been prescribed postsurgically for prophylaxis, it was discontinued and the patient's serum phenytoin concentration declined to the previous steady-state level with no change in dose or other drug therapy. This case indicates that the serum phenytoin concentration should be monitored for the first month after the addition of ranitidine to the regimens of patients on chronic phenytoin therapy. As well, further clinical investigation of factors affecting the interindividual inhibitory action of ranitidine is warranted.
Physicians' Review of Significant Interventions by Clinical Pharmacists in Inpatient Care
Authors: Hatoum Hind T. , Hutchinson Richard A. , Elliott Lawana R. , Kendzierski Donald L.
Published: May 2016

Clinical pharmacists in this study hospital reported 1027 interventions in patient drug therapy over two time periods of three and two weeks each. When peer-reviewed for clinical significance, 36 of these interventions were deemed significant in terms of saving patients' lives or preserving major organ functions; 983 were judged to improve drug therapy to an acceptable level based on standards of the professional literature (8 recommendations were informational i.e., not clinically significant).

These 36 interventions were subjected to an independent, blind review by three practicing physicians who were given the same ranking system for clinical relevance as the one used by the peer reviewers. The physicians independently concurred with the peer reviewers on the two interventions initially ranked as 6 (lifesaving in nature). Of the interventions ranked 5 (preserving major organ functions) by the peer-review group, 53 percent were given a rank of 5 by the physicians. However, the remaining 47 percent were given a rank of 4 (upgrading patient drug therapy to the most appropriate level based on professionally accepted standards). In this era of program evaluation and justification, the process of encouraging other health professionals to review pharmacists' contribution to patient care should not be overlooked.
Pharmacoeconomic Impact of Critically Ill Surgical Patients
Authors: Dasta Joseph F. , Armstrong Deborah K.
Published: May 2016

Financial information on 131 patients and drug-related information on 176 patients admitted to a surgical intensive care unit (ICU) were prospectively collected. The average stay was nearly five days and patients received 8.6 drugs per day for a total average exposure of 12.2 different drugs. Antibiotics and analgesics were used in over 90 percent of patients. The patients' diagnoses fit into 53 different diagnosis-related groups (DRG). Hospital costs were significantly greater than DRG payment for an average revenue loss of $17 803 per patient. Patients with a primary diagnosis of sepsis had the largest revenue loss, averaging $54 738. One hundred patients were revenue losers. Total hospital stay was statistically longer than DRG-projected length of stay. Pharmacy charges averaged 13.6 percent of total hospital charges. Patients receiving systemic antifungals, triple antibiotics, catecholamines, and total parenteral nutrition had high hospital and pharmacy costs. This study suggests that ICU patients are costly to hospitals and that drug use is expensive. We suggest that increased pharmacy involvement in the care of ICU patients may help curtail escalating drug costs in these patients.
Development and Evaluation of the Adult Daughter–Mother Relationship Questionnaire (ADMRQ)
Authors: Cwikel Julie
Published: May 2016

The mother–daughter relationship is embedded in a rich cultural and social context and is critical for maintaining identity and mental health over women’s adult lives. This article describes the development and preliminary psychometric evaluation of the Adult Daughter–Mother Relationship Questionnaire (ADMRQ). Research was conducted in three phases: (1) summary statements about mother–daughter relationships were extracted from 48 mother–daughter in-depth interviews from a variety of ethnic groups. These formed a draft questionnaire; (2) this initial questionnaire was circulated to 10 psychotherapists to assess face and content validity; and (3) the questionnaire was completed by a sample of 147 students and community-dwelling women including a subsample of 34 women who were currently in psychotherapy. Exploratory factor analysis revealed three major factors in the ADMRQ accounting for 49.4% of the variance: both positive and negative affect, ambivalent feelings in the relationship, and interdependency relationships. Cronbach’s αs of additive scales ranged from .625 to .927. Test–retest reliability was established.
Bridging the Nomothetic and Idiographic Approaches to the Analysis of Clinical Data
Authors: Beltz Adriene M. , Wright Aidan G. C. , Sprague Briana N. , Molenaar Peter C. M.
Published: May 2016

The nomothetic approach (i.e., the study of interindividual variation) dominates analyses of clinical data, even though its assumption of homogeneity across people and time is often violated. The idiographic approach (i.e., the study of intraindividual variation) is best suited for analyses of heterogeneous clinical data, but its person-specific methods and results have been criticized as unwieldy. Group iterative multiple model estimation (GIMME) combines the assets of the nomothetic and idiographic approaches by creating person-specific maps that contain a group-level structure. The maps show how intensively measured variables predict and are predicted by each other at different time scales. In this article, GIMME is introduced conceptually and mathematically, and then applied to an empirical data set containing the negative affect, detachment, disinhibition, and hostility composite ratings from the daily diaries of 25 individuals with personality pathology. Results are discussed with the aim of elucidating GIMME’s potential for clinical research and practice.
Magnetic resonance venography to assess thrombus resolution with edoxaban monotherapy versus parenteral anticoagulation/warfarin for symptomatic deep vein thrombosis: A multicenter feasibility study
Authors: Piazza Gregory , Mani Venkatesh , Goldhaber Samuel Z , Grosso Michael A , Mercuri Michele , Lanz Hans J , Schussler Steven , Hsu Ching , Chinigo Amy , Ritchie Bruce , Nadar Venkatesh , Cannon Kevin , Pullman John , Concha Mauricio , Schul Marlin , Fayad Zahi A ,   for the edoxaban Thrombus Reduction Imaging Study (eTRIS) Investigators
Published: May 2016

The feasibility of magnetic resonance venography (MRV) for measuring change in thrombus volume with a novel anticoagulation regimen versus standard anticoagulation in patients with symptomatic deep vein thrombosis (DVT) has not been assessed. Our aim was to study the feasibility of MRV to measure change in thrombus volume in patients with acute symptomatic objectively confirmed proximal DVT in an open-label multicenter trial (edoxaban Thrombus Reduction Imaging Study, eTRIS). We randomized patients in a 2:1 allocation ratio to edoxaban 90 mg/day for 10 days followed by 60 mg/day versus parenteral anticoagulation bridging to warfarin for 3 months. The primary efficacy outcome was a surrogate end point of the relative change in MRV-quantified thrombus volume from baseline to Day 14–21. A total of 85 eligible patients from 26 study sites were randomized to edoxaban monotherapy ( n=56) versus parenteral anticoagulation as a ‘bridge’ to warfarin ( n=29). The mean relative change in MRV-quantified thrombus volume from baseline to Day 14–21 was similar in patients treated with edoxaban and parenteral anticoagulation as a ‘bridge’ to warfarin (−50.1% vs −58.9%; 95% confidence interval of treatment difference, −12.7%, 30.2%). However, thrombus extension was observed in eight patients in the edoxaban monotherapy group and in none in the warfarin group. Rates of recurrent venous thromboembolism (3.6% vs 3.6%, p=0.45) and clinically relevant non-major bleeding (5.4% vs 7.1%, p=0.34) were also similar. No major bleeds occurred in either on-treatment group during the study period. In conclusion, MRV can assess change in thrombus volume in patients with acute DVT randomized to two different anticoagulant regimens.

ClinicalTrials.gov Identifier: NCT01662908

Investigational New Drug (IND) Application: Edoxaban IND # 63266
Seismic performance of a controlled rocking reinforced concrete frame
Authors: Lu Liang , Liu Xia , Chen Junjie , Lu Xilin
Published: May 2016

A controlled rocking reinforced concrete frame is a new type of vibration control structure system that uses resilient rocking columns and joints. The effects of earthquakes on this type of structure are reduced by weakening the overall stiffness, whereas the lateral displacement is controlled by the energy-dissipation dampers introduced into the structure. Two tests were performed for research: the reversed cyclic loading test and shaking table test. Two single-span single-story controlled rocking reinforced concrete frames were designed for reversed cyclic loading tests. These tests (i.e. a column-base joint stiffness test, beam-column joint stiffness test, and frame stiffness test) were performed under different conditions. The mechanical analysis model of the rocking joints was derived from the test results. With the parameters obtained from the cyclic tests, a numerical simulation method that established the analytical model of the controlled rocking reinforced concrete frame using the program ABAQUS is proposed, and the dynamic time-history analysis results of the controlled rocking reinforced concrete frame and of the conventional approach are compared to investigate the vibration control effect and seismic performance of the controlled rocking reinforced concrete frame. In addition, the inter-story drift could be effectively controlled by adding metallic dampers, and the shaking table test models of the controlled rocking reinforced concrete frame with metallic dampers were designed and constructed. The comparison of the results of the numerical analysis and the shaking table test demonstrates that the model building of the controlled rocking reinforced concrete frame structure is efficient and that the controlled rocking reinforced concrete frame exhibits an excellent seismic performance.
Seismic behaviour of a steel frame partially infilled with precast reinforced concrete wall
Authors: Jiang Liqiang , Zheng Hong , Hu Yi
Published: May 2016

A steel frame partially infilled with precast reinforced concrete wall (RPWF) is proposed as a new lateral resisting system for building structures. In this system, to achieve partially infilled construction, the precast reinforced concrete wall (RPW) is connected with the steel frame beam only through high-strength bolts. To investigate the seismic behaviour of steel frames strengthened by RPW, three test specimens (one-bay, one-storey and one-third scale) were constructed and tested under constant axial loading and reversed cyclic loading. The length-to-height ratio of the infilled wall was the parameter of the test study. The test results showed that partially infilled steel frames exhibited higher initial stiffness and higher loading capacity than the bare steel frame. The ductility and energy dissipation capacity of the RPWF were increased, whereas the length-to-height ratio of the RPW was decreased. Finally, theoretical and pushover analyses were developed to predict the ultimate loading capacity of the tested specimens, and the accuracy was validated by the test results.
Bilateral medial epicondyle fractures with elbow dislocations in an adolescent female athlete
Authors: Sybert Michael W , Hennrikus William L
Published: May 2016

To date, only two cases of bilateral elbow dislocations with medial epicondyle fractures have been reported. The current case is an 11-year-old girl who sustained bilateral elbow dislocations with medial epicondyle fractures by landing on extended elbows while performing a back handspring on a trampoline. Closed reduction and splinting were performed in the emergency room. Open reduction with screw fixation of the medial epicondyle fractures was performed in the operating room. Post-operatively, the patient was splinted for eight days followed by range of motion exercises. She returned to full sports participation at 15 weeks. On final follow-up 24 months later, the patient had full range of motion, normal strength, and normal neurovascular examination. Compared to the two previous case reports in the literature, this is the only case report demonstrating full range of motion, full strength, and full return to sports after bilateral elbow dislocation with medial epicondyle fractures. Keys to complete recovery included internal fixation with a screw and washer followed by early range of motion.
Mass probation: Toward a more robust theory of state variation in punishment
Authors: Phelps Michelle S
Published: May 2016

Scholarship on the expansion of the U.S. carceral state has primarily focused on imprisonment rates. Yet the majority of adults under formal criminal justice control are on probation, an “alternative” form of supervision. This article develops the concept of mass probation and builds a typology of state control regimes that theorizes both the scale and type of punishment states employ. Drawing on Bureau of Justice Statistics data from 1980 and 2010, I analyze whether mass probation developed in the same places, affecting the same demographic groups and driven by the same criminal justice trends, as mass imprisonment. The results show that mass probation was a unique state development, expanding in unusual places like Minnesota and Washington. The conclusions argue for a reimagining of the causes and consequences of the carceral state to incorporate the expansion of probation.
The effect of coupled lateral and torsional vibrations of an unbalanced Jeffcott rotor supported by roller bearings
Authors: Yu Yupeng , Liu Heng , Ni Yuquan , Jing Minqing
Published: May 2016

In this paper, an unbalanced Jeffcott rotor supported by the roller bearings is modelled, and the dynamic differential equations are obtained by the Lagrange’s equations. The fourth order Runge–Kutta method is employed to simulate this system in two cases. Simulation results show the combined effect of the coupled lateral and torsional vibrations and the variable compliance vibration of the rotor. In the case of that only a large and constant radial force is applied, the sum and difference between variable compliance and rotational frequency components of the torsional vibrations of the disk are induced because of the roller bearings’ rotation. And when they are near to the natural frequency of the torsional vibration, the resonance peaks appear. In the case of that a large and constant radial force and a harmonic torque are simultaneously applied, the two components, the sum and difference between rotational frequency and the frequency of the external torque, of the lateral vibrations of the disk are induced. When the frequency of the external harmonic torque approximatively equal to a special value, the two frequency band lines, variable compliance and the sum of rotational frequency and the frequency of external torque, intersect near the natural frequency of the lateral vibration, and the vibration may aggravate.
To protect and to support: How citizenship and self-determination are legally constructed and managed in practice for people living with dementia in Sweden
Authors: Nedlund Ann-Charlotte , Taghizadeh Larsson Annika
Published: May 2016

Since living with dementia implies increasing difficulties in taking charge of rights due to cognitive as well as communicative impairments, many people with dementia are vulnerable and in need of support in order to realize full citizenship. In Sweden, all adults right to self-determination is strongly emphasized in law, regulations, and policies. Further, and in contrast to the situation in many other countries, people living with dementia cannot be declared as incompetent of making decisions concerning social care and their right to self-determination cannot legally be taken away. The article shows that in the Swedish welfare system, the focus is more on protecting the self-determination of citizens than on supporting people in making decisions and exercising citizenship. Subsequently, this causes legally constructed zones of inclusion and exclusion. This article examines and problematizes how different institutional contexts, legal constructions, norms, and practices in Sweden affect the management of issues concerning guardianship, supported decision-making and self-determination, and outline the implications for people living with dementia.
‘Gonna make yer gorgeous’: Everyday transformation, resistance and belonging in the care-based hair salon
Authors: Ward Richard , Campbell Sarah , Keady John
Published: May 2016

This paper makes a contribution to an emerging debate on dementia and citizenship through a focus on the everyday experiences of women living with dementia and in receipt of care. In particular, a link is drawn between hairdressing and citizenship in the context of dementia care. Informed by a wider debate over the importance of an emplaced, embodied and performative approach to citizenship, the authors highlight the way that intersecting forms of resistance unfold in the salon. The Hair and Care project, as the name implies, focused upon hair care and styling in the context of a wider consideration of appearance and how it is managed and what it means for people living with dementia. With a focus upon the routine, mundane and thereby often unproblematised aspects of everyday life in/with care, the discussion draws together two key ideas concerned with the interplay of power and resistance: Essed’s (1991) theory of ‘everyday discrimination’ and Scott’s (1985) notion of ‘everyday resistance’. The findings illuminate the creative and collective forms of agency exercised by older women living with dementia, in the context of their relationships with one another and with the hairdressers whose services and support inspire their loyalty and patronage. Findings from the study point to the link between (inter-)personal practices of appearance management and a wider set of social conditions that are manifest in the on-going struggle over time, space and bodies in dementia care.
Narrative citizenship, resilience and inclusion with dementia: On the inside or on the outside of physical and social places
Authors: Clarke Charlotte L , Bailey Cathy
Published: May 2016

There has been little research that addresses the importance of place in enabling resilience and citizenship – most to date focussing on these as a characteristic of the individual. This paper reports on findings from a qualitative study that aimed to explore the everyday experiences of living with dementia within rural and semi-urban communities. Data collection included a sequence of four research diaries and interviews with 13 families living at home with dementia and interviews with service providers and commissioners (a total of 57 diaries, 69 interviews with people living with dementia and 6 interviews with service providers and commissioners). Key themes identified included: Others Knowing and Responding; Socially Withdrawing and Feeling Excluded; Sustaining and Changing Activities; Belonging and Estrangement from Place; Engaging Services and Supports. The study found that familiarity with people and place can be supportive, and these factors support a narrative citizenship in which people can tell a story of inclusion and feeling on the inside. However, this familiarity with place may also create a social barrier and a sense of estrangement, or being on the outside. Narrative citizenship allows us to explore how people with dementia position themselves in relation to others and in so doing, negotiate their own and other’s understandings of dementia. It also allows for people to tell stories about themselves in relation to their sense of belonging in a social and physical place, which augment the personal and political approaches to citizenship and thus offers an approach that enhances individualised yet collective understandings of living with dementia.
Lockouts and Player Productivity
Authors: Ge Qi , Lopez Michael J.
Published: May 2016

We implement a propensity score matching technique to present the first evidence on the impact of professional sports lockouts on player productivity. In particular, we utilize a unique natural experiment from the 2012-2013 National Hockey League lockout, during which approximately 200 players decided to play overseas, while the rest stayed in North America. We separate players based on their nationality and investigate the effect of playing abroad on postlockout player performance. We find limited evidence of enhanced productivity among European players and no evidence of a benefit or drawback for North American players. Our study contributes to the understanding of lockouts in professional sports and the general discussion of labor disputes and worker productivity.
Reference Points, Prospect Theory, and Momentum on the PGA Tour
Authors: Stone Daniel F. , Arkes Jeremy
Published: May 2016

Pope and Schweitzer (2011) study predictions of prospect theory for the reference point of par on the current hole in professional golf. We study prospect-theory predictions of three other plausible reference points: par for recent holes, for the round, and for the tournament. A potentially competing force is momentum in quality of play, that is, the hot or cold hand. While prospect theory predicts negative serial correlation in better (worse)-than-average performance across holes, the hot (cold) hand implies the opposite. We find evidence that, for each of the reference points we study, when scores are better than par, hot-hand effects are dominated by prospect-theory effects. These effects can occur via two mechanisms: greater conservatism or less effort. We find evidence that the former (latter) dominates for scores closer to (further from) the reference point. We also find evidence of prospect theory effects (greater risk seeking) when scores are worse than par for the round in Round 1 and of cold-hand effects for scores worse than par for the tournament in Round 3. The magnitudes of some of the joint effects are comparable to those found by Pope and Schweitzer and other related papers. We conclude by discussing how, rather than compete, prospect-theory and cold-hand forces might also cause one another.
Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease
Authors: Manukhina Eugenia B , Downey H Fred , Shi Xiangrong , Mallet Robert T
Published: May 2016

Alzheimer's disease (AD) is a leading cause of death and disability among older adults. Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes mellitus, sleep apnea, and metabolic syndrome. Here, interactions between cerebrovascular function and development of AD are reviewed, as are interventions to improve cerebral blood flow and reduce VRF. Atherosclerosis and small vessel cerebral disease impair metabolic regulation of cerebral blood flow and, along with microvascular rarefaction and altered trans-capillary exchange, create conditions favoring AD development. Although currently there are no definitive therapies for treatment or prevention of AD, reduction of VRFs lowers the risk for cognitive decline. There is increasing evidence that brief repeated exposures to moderate hypoxia, i.e. intermittent hypoxic training (IHT), improve cerebral vascular function and reduce VRFs including systemic hypertension, cardiac arrhythmias, and mental stress. In experimental AD, IHT nearly prevented endothelial dysfunction of both cerebral and extra-cerebral blood vessels, rarefaction of the brain vascular network, and the loss of neurons in the brain cortex. Associated with these vasoprotective effects, IHT improved memory and lessened AD pathology. IHT increases endothelial production of nitric oxide (NO), thereby increasing regional cerebral blood flow and augmenting the vaso- and neuroprotective effects of endothelial NO. On the other hand, in AD excessive production of NO in microglia, astrocytes, and cortical neurons generates neurotoxic peroxynitrite. IHT enhances storage of excessive NO in the form of S-nitrosothiols and dinitrosyl iron complexes. Oxidative stress plays a pivotal role in the pathogenesis of AD, and IHT reduces oxidative stress in a number of experimental pathologies. Beneficial effects of IHT in experimental neuropathologies other than AD, including dyscirculatory encephalopathy, ischemic stroke injury, audiogenic epilepsy, spinal cord injury, and alcohol withdrawal stress have also been reported. Further research on the potential benefits of IHT in AD and other brain pathologies is warranted.
Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2
Authors: Farías Jorge G , Carrasco-Pozo Catalina , Carrasco Loza Rodrigo , Sepúlveda Néstor , Álvarez Pedro , Quezada Mauricio , Quiñones John , Molina Víctor , Castillo Rodrigo L
Published: May 2016

The mechanistic evidence to support the cardioprotective effects of polyunsaturated fatty acids (PUFA) are controversial. The aim was to test cardioprotective mechanisms induced by PUFA supplementation against cardiac ischemia-reperfusion (IR) injury. Ten-week-old male Wistar rats (225 ± 14 g, n = 14) were divided in two groups: rats without supplementation ( n = 7) and a PUFA group, supplemented by PUFA (0.6 g/kg/day; DHA:EPA = 3:1) for eight weeks ( n = 7). Hearts were perfused with Krebs–Henseleit buffer for 20 min (control conditions); others were subjected to control conditions, 30 min of global ischemia and 120 min of reperfusion (IR group). Infarct size (IS) and left ventricular developed pressure (LVDP) were measured at 120 min of reperfusion. Oxidative stress biomarkers (TBARS, total carbonyls), antioxidant status (CAT, catalase; SOD, superoxide dismutase; GSH-Px, glutathione peroxidase activity and GSH/GSSG ratio), myeloperoxidase activity, ATP levels and nuclear transcription factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappaB (NF-κB) were determined in both experimental conditions. At the end of reperfusion, hearts supplemented with PUFA showed lower IS and a higher LVDP compared with the nonsupplemented rats. Hearts in the group supplemented with PUFA showed lower levels of oxidative stress markers and higher antioxidant activity, decreased MPO activity and NF-κB and Nrf2 activation compared with the nonsupplemented group. Cardioprotective effects of PUFA are exerted through induction of anti-inflammatory and antioxidant mechanism at tissue level.
Efforts to Curtail the Spread of Adult Entertainment in Portland, Oregon, through the Use of Public Policy and Urban Planning, 1970–1987
Authors: Morehead Elizabeth Mylott
Published: May 2016

Like many American cities, Portland attempted to use urban planning and policy to control the geographic spread of adult entertainment during the 1970s. Portland’s efforts, however, were complicated by Oregon’s famously liberal state constitution. City Hall, the City Attorney, and the Planning Bureau spent nearly two decades trying to find a solution that would please angry city residents without violating the state constitution. As city officials worked to find a unique solution for their city, the technology used to disseminate adult entertainment was changing. Technological change was more rapid than policy change. The regulations ultimately adopted by the city did not fit the new landscape of adult businesses.
Closed gastroschisis, vanishing midgut and extreme short bowel syndrome: Case report and review of the literature
Authors: Dennison FA
Published: May 2016

Gastroschisis alone has excellent survival rates. Occasionally reported is closed gastroschisis, leading to vanishing small bowel and extreme short bowel syndrome. It is believed that the abdominal wall defect can contract or close in utero, which leads to strangulation of the eviscerated bowel and the rare “vanishing gut syndrome.” This has a very poor prognosis with mortality as high as 70%. An 18-year-old primigravid patient’s 13 week scan diagnosed a large gastroschisis affecting the fetus. After counselling, she decided to continue with the pregnancy. Between 20 and 22 weeks, the gastroschisis disappeared, and the bowel within the abdomen became markedly dilated. Spontaneous labour occurred at 33 + 3 weeks gestation. There was no abdominal wall defect seen at delivery. Imaging and an exploratory laparotomy demonstrated absence of most of the midgut. Because available options for treatment would be very aggressive and risky, palliative care was thought to be the most feasible and practical option. He died at home on day 29 after birth. Extreme short gut syndrome (less than 25 cm of remaining small bowel) is rare. There are 13 reported cases in the literature from year 2000 to 2013. Treatment is aggressive and involves a bowel lengthening procedure or small bowel transplant. All require total parenteral nutrition and liver failure, and liver transplant is a common complication. Of these cases, 12 were born alive and 7 had aggressive treatment. Only two cases were confirmed to still be alive in infancy. If gastroschisis is seen to be reducing and “disappearing” antenatally, parents should be made aware of this rare complication so that they might be prepared if a poor outcome is anticipated.