bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Behavioral FactorsTerhadap Pengambilan Keputusan Investasi Finansial Individu
Authors:   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Khalisa Anita , Kurnia Karismasari Charpri ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Hikmatul Ikhsan Hirzi ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Saraswati Niken ,   School of Business and Economics Universitas Prasetiya MulyaJL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia
Published: July 2021

Tujuan penelitian adalah untuk mengetahui pengaruh behavioral factorsinvestor yang terdiri dari sentiment, overconfidence, overreaction and underreaction and herd behaviorterhadap pengambilan keputusan investasi di pasar modal di Jakarta.Hasil penelitian menunjukkan bahwa behavioralfactorsinvestor sentiment, overreaction dan underreaction, danherd behaviormemiliki pengaruh terhadap keputusan investasi sedangkan behavioralfactor overconfidencetidak memiliki pengaruh terhadap keputusan investasi. Halini menunjukkan bahwa investor di Pasar Modal di Jakarta masih terpengaruh oleh faktor emosional, dan juga informasi dari luardalam mengambil keputusan investasi, seperti contohnyainformasipergerakan harga saham, pendapat orang yang dianggap lebih ahli, ataupunsumber internet. Oleh karena itu, dari hasil ini diharapkan para pembuat kebijakan atau manajer portfoliountuk dapat semakin memberikan transparansi mengenai informasi dan risiko investasi yang akan diperoleholeh investor.Selain itu, bagi investor individu diharapkan dapat mencari dan mempelajari data yang lebih baik dalam sebelum mengambil keputusan. Jurnal ini menggunakan referensi dari dua jurnal penelitian yang pernah dilakukan sebelumnya:(Metawa et al.2018)dan(Mahanthe& Sugathadasa2019)
Faktor Penentu Penggunaan Dompet Digital pada Konsumen di Daerah Jabodetabek
Authors:   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Daulay Denni Irawan , Alfiyanna Gita ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Anggraeni Indah ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Sitohang Reny Aurora ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Simatupang Teddy ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia.
Published: July 2021

Mereplikasi penelitian oleh Ahuja dan Joshi (2018) yang dilakukan di India, penelitian ini dilakukan di Jabodetabek untuk mencari faktor-faktor penentu dalam penggunaan dompet digital. Penelitian oleh Ahuja dan Joshi (2018), mendapatkan bahwa faktor-faktor tersebut, dari yang pengaruhnya paling tinggi sampai yang paling rendah adalah: ease of use, benefit, trust, dan self efficacy. Sedikit berbeda, penelitian ini mendapatkan bahwa 4 faktor penentu penggunaan dompet digital di Jabodetabek, dengan urutan pengaruh dari yang paling tinggi ke yang paling rendah yaitu ease of use, self efficacy, benefit, dan trust. Walaupun penelitian ini menggunakan jumlah responden yang lebih banyak dan dengan menggunakan tambahan kuesioner baik dari beberapa sumber jurnal maupun dari hasil wawancara, didapat hasil yang mirip dengan penelitian oleh Ahuja dan Joshi (2018). Ease of use atau kemudahan dalam menggunakan aplikasi menjadi satu keharusan agar baik penyedia jasa layanan yang sekarang maupun yang akan datang, agar mempunyai daya saing yang tinggi. Ketiga faktor lainnya juga penting untuk diperhatikan tanpa mengganggu kemudahan dalam menggunakan aplikasi.
Dampak Sistem Pengamanan Data di Layanan OVO terhadap Peningkatan Penggunanya
Authors:   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Subrata Alvin , Yutanto Andriany ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Sulastri Simangunsong Budi Altati ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Hanom Simatupang Ernest Eliot ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Widodo Henri ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia.
Published: July 2021

Sistem Pembayaran Elektronik (SPE) telah meningkatkan kualitas hidup individu dengan memberikan kemudahan bertransaksi online. Kami membahas sistem pembayaran OVO sebagai aplikasi selular yang paling banyak digunakan di Jakarta pada khususnya. Penelitian ini menguji dampak sistem pengamanan data pada layanan OVO terhadap peningkatan penggunanya. Dari 262 sampel responden yang dianalisa; hasilnya menunjukkan bahwa baik persepsi keamanan dan kepercayaan memiliki pengaruh signifikan terhadap penggunaan OVO. Perlindungan teknis dan pengalaman masa lalu menjadi penentu umum dari rasa aman dan kepercayaan yang dirasakan. Implikasi manajerial dari temuan dibahas secara ringan dalam keterbatasan penelitian dan saran untuk penelitian lebih lanjut.
A radical tumor resection and vascular plastic with xenopericardium as part of complex therapy in a patient with second relapse of nephroblastoma. Case report and literature review
Authors: Gurgenidze N. N. , Shvetsov A. N. , Zaytseva A. N. , Trushin A. A. , Kazantsev I. V. , Gevorgyan A. G. , Ananyev A. N. , Zakharenko A. A. , Punanov Yu. A. , Kulagin A. D. , Zubarovskaya L. S.
Published: July 2021

In spite of a relatively good prognosis of most patients with nephroblastoma, there are some subgroups characterized by different unfavorable prognostic factors, in which the overall prognosis is much worse. In particular, this can be applied to patients with very high risk relapse. As in these cases the tumor is often resistant to most chemotherapy modalities, the quality of surgical control is of utmost importance.

We present a case of a 9-year-old patient with second local nephroblastoma relapse involving a large portion of inferior vena cava. During the course of complex therapy a radical surgical resection with vascular plastic by xenopericardium implant was performed. The follow-up, albeit short, yields no signs of disease progression or graft malfunction.

This case demonstrates the possibility of successful vascular plastic in a child with relapsed tumor. This method may allow more radical tumor resection.
The clinical course of cutaneous mastocytosis in a prospective group of 163 children according to electronic parent survey
Authors: Potapenko V. G. , Baykov V. V. , Boychenko E. G. , Zaslavsky D. V. , Krasnogorskaya O. L. , Krivolapov Yu. A. , Lisukova E. V. , Seminiv S. Ya. , Skoryukova K. A. , Sydikov A. A. , Kulibaba T. G.
Published: July 2021

Introduction. Mastocytosis occurs due to clonal mast cells proliferation and may have different clinical course. As the disease only rarely occurs in pediatric population there are very few clinical observations describing its symptoms, prognosis and therapy response in pediatric cohorts.

Aim of the study — characterization of gender, sympthoms, prognosis and therapy in children with mastocytosis using data obtained by electronic parent survey.

Methods. The study data was collected from November 2014 till August 2020 from parents referring for consultation of hematologist via “Vkontakte” social network. All parents completed two surveys. The first one was performed right after the referral, the second one was performed from May 2020 to August 2020. The data on age at symptoms onset, family history, symptoms, rash distribution, serum tryptase concentrations, sunlight sensitivity and clinical course was obtained and analyzed.

Results. The data on 163 children was obtained, 86 (52.7 %) of them were boys and 77(47.3 %) were girls. The median age was 6 (0.5—22) years. At the end of survey the median observation time was 61.5 (2—276) months. The most common mastocytosis clinical variant was urticaria pigmentosa (n = 129; 79.1 %), mastocytoma in 18 (11 %) and in 15 (9.9 %) an unknown variant was observed. The diagnosis was based on skin biopsy in 19 patients (11.6 %). Characteristic symptoms were seen in 123 (75.4 %) children. The main complaints were skin reaction triggered by various factors (n = 89; 72.3 %) and itching (n = 78; 63.4 %). Most patients took antihistamines (n = 64; 61 %) and ketotifen (n = 22; 21 %). The second survey was conducted in 139 (85.2 %) pts. At the time of survey symptoms progression was seen in 4 (2.9 %) patients, while in 42 (30.2 %) cases stabilization, and in 93 (66.9 %) cases improvement were observed.

Conclusion. The symptoms onset mostly occurs in the first year of life. Most frequents symptoms are itching and rash in response to various triggers. Antihistamine drugs led to symptoms mitigation. The clinical course is benign in most children.
Resolution of the Expert council on current issues of prescribing clotting factor VIII with prolonged half-life (INN — Efmoroctocog alfa) in patients with hemophilia A
Authors: Editorial Article
Published: July 2021

В ходе Совета экспертов, который состоялся 11 мая 2021 г., обсуждались критерии назначения препарата фактора свертывания крови VIII (эфмороктоког альфа) с пролонгированным периодом полувыведения пациентам с гемофилией А.
Von Willebrand factor multimeric assay: novel diagnostics capabilities
Authors: Poletaev A. V. , Seregina E. A. , Pshonkin A. V. , Karamyan N. A. , Fedorova D. V. , Plyasunova S. A. , Zharkov P. A.
Published: July 2021

Introduction. Distinguishing between Von Willebrand disease (vWD) types often requires multimer gel analysis. The current techniques for vWF multimer structure are manual, complicated, non-standardized and time consuming. The aim of this study was to evaluate diagnostic capabilities of new automated vWF multimer screening assay.

Materials and methods. Children with vWD, acquired von Willebrand Syndrome (aVWS) and 8 healthy donors as a control group were enrolled in this study. Von Willebrand factor antigen (vWF Ag); ristocetin cofactor activity (VWF:Rco); vWF collagen binding (VWF:CB); ristocetin-induced platelet aggregation (RIPA); factor VIII clotting activity (FVIII:C) and vWF factor VIII binding activity (vWF:FVIIIb) were performed to evaluate vWD. Multimer analysis was carried out using the commercial HYDRAGEL 5 von Willebrand Multimers kit on semi-automatic gel electrophoresis instrument HYDRASYS (SEBIA).

Results. The samples from control group had 9—12 bands of vWF multimers with the same distribution as control plasma. Patients with type I vWD had the proportional decrease in the intensity of the bands with preservation of the normal distribution of the band. Patients with type III vWD reveal the complete absence of the multimer bands on the gel. Multimer analysis in type IIA shows the absence of high molecular weight multimer bands. In other patients the distribution of vWF multimers was normal against the changes in functional properties of vWF (types IIM, N). Most of the children with aVWS also revealed normal distribution of vWF multimers, however, in some patients, the slight decrease in large multimeric forms was observed visually on the gel.

Conclusion. Multimer analysis allows to visualize the multimer distribution in various types of von Willebrand disease. The method is easy to perform and can be useful for distinguishing between the subtypes of vWD. But only the full test panel including genetic tests would allow the differentiantion of vWD types with high precision.
Treatment of severe infectious complications caused by multidrug-resistant Klebsiella pneumoniae in children with malignant neoplasms of the hematopoietic system: experience of the Research Institute of Pediatric Oncology and Hematology at N.N. Blokhin Russian Cancer Research Center
Authors: Sidorova N. V. , Machneva E. B. , Valiev T. T. , Kostareva I. O. , Aliev T. Z. , Elfimova A. Yu. , Lozovan Yu. V. , Pavlova T. Yu. , Korkina Yu. S. , Gorbunova T. V. , Grigorievskaya Z. V. , Petukhova I. N. , Epifanova N. Yu. , Kirgizov K. I.
Published: July 2021

Introduction. So far there has been no clear protocol on the treatment of bacterial infections in hematopoietic cancer patients undergoing polychemotherapy (PCT) and hematopoietic stem cell transplantation (HSCT). Guidelines available from antibiotic therapy panels such as EMBT, NCCN, ECIL, Sepsis-3 often fail to cover the entire spectrum of clinical risk factors of severe complications caused specifically by multiresistant Klebsiella pneumoniae.

The aim of the study — is to showcase the clinical experience of demonstration of the experience of the Research Institute of Pediatric Oncology and Hematology at N.N. Blokhin Russian Cancer Research Center with respect to adjusting antibacterial therapy for the spectrum of microorganisms found in the patient before the onset of antitumor therapy, and for the multiresistant microorganism findings in patients with blood cancers and febrile neutropenia (FN) undergoing PCT and HSCT.

Materials and methods. The study involved five patients undergoing either PCT or HSCT for hematopoietic cancers at Research Institute of Pediatric Oncology and Hematology in October 2019 — October 2020, multiresistant Klebsiella pneumonia colonies found in each case. Results. Five patients with hematopoietic cancers and induced bone marrow aplasia were found to have multiresistant Klebsiella pneumoniae colonies on top of post-PCT/HSCT immunosuppression. Given high risk of death, these patients need early antibacterial therapy with reserve antibiotics outside standard empirical antibacterial treatment protocols should they develop FN. The Center's practices have shown that baseline protocols are often inadequate to the severity of these patients' conditions in a certain timeframe.

Conclusions. To sum up the Center's limited experience, the finding is that additional research is required into the factors of risk of severe multiresistant Klebsiella pneumoniae infections in patients undergoing PCT and HSCT; algorithms must be developed for the treatment of patients in such a critical condition.
Predictive biomarkers of inhibitors immune checkpoints therapy in malignant tumors
Authors: Kiselevsky M. V. , Samoylenko I. V. , Zharkova O. V. , Ziganshina N. V. , Petkevich A. A. , Sitdikova S. M. , Suleymanova A. M. , Sagoyan G. B. , Efimova M. M. , Kirgizov K. I. , Varfolomeeva S. R.
Published: July 2021

Immune checkpoint inhibitors (ICT) therapy is a successful immunotherapy (IT) strategy that is quite effective in a number of patients with non-small cell lung cancer, melanoma, bladder cancer, breast cancer and others. Nevertheless, there is a need in predictive markers for ICT therapy for personalized IT as far as there is a large group of patients, the proportion of which varies depending on the tumor, who do not have a clinical response to such therapy. The review summarizes the theoretical aspects and results of clinical trials dedicated to various clinical efficiency predictor using modern databases. As a result of the analysis it is established that the main candidates for the role of such markers are tumor infiltrating lymphocytes and their subpopulations, peripheral blood lymphocytes (PBL) and their subpopulations. PD1 (programmed death receptor 1) and PDL1 (programmed death receptor ligand 1) expression in tumor tissue can also be important for predicting IT efficiency. The most promising predictive biomarker meaning the most clinically relevant is a combination of the PBL subpopulations study and PD1 and PDL1 expression on the tumor cells.

PubMed, Scopus, Web of Science, eLibrary, Russian Science Citation Index databases were searched for the available appropriate literature reports. The authors included 82 in the given review.
The latest trends in improving CAR-T cell therapy: from leukemia to solid malignant tumors
Authors: Ershov A. V. , Demyanov G. V. , Nasrullaeva D. A. , Radkevich E. R. , Dolgikh V. T. , Sidorova N. V. , Valiev T. T. , Efimova M. M. , Machneva E. B. , Kirgizov K. I. , Kiselevsky M. V. , Manasova Z. Sh.
Published: July 2021

CAR-Т cell therapy with the use of cytotoxic lymphocytes with chimeric antigen receptors occupies an important place among modern approaches to the cancer treatment. This therapy has established itself as an effective method of the treatment of CD19+ acute lymphoblastic leukemia. Nevertheless, the recurrences of the illness are not uncommon; the treatment of solid tumors with genetically engineered lymphocytes shows modest results and it is accompanied by the high toxicity. One thing, however, is certain: CAR-Т cell therapy has great potential in the treatment of cancer and further improving of the structure and functions of genetically engineered lymphocytes with chimeric Т cell receptors help greatly increase the efficiency of antitumor treatment.

The review includes the current data on the structure of chimeric lymphocytes of different generations and the trends in improving CAR-Т cell therapy. It includes also the fundamental platform for formation of ideology of use CAR-Т cells for the treatment of solid malignant tumors.
2,5-Disubstituted-4-Thiazolidinones: Synthesis, Anti-Inflammatory, Free Radical Scavenging Potentials and Structural Insights through Molecular Docking
Authors: Singh Jagseer , Chawla Pooja A. , Bhatia Rohit , Singh Shamsher
Published: July 2021

The present work reports the synthesis and screening of fifteen 2,5-disubstituted-4-
thiazolidinones with different substitutions at imino and varied arylidene groups. The structures of the
compounds were confirmed by spectral characterization. The compounds were subjected to in vivo anti-
inflammatory and in vitro antioxidant activities. The derivatives possessed remarkable activities
quite close to standard drugs used. Unlike conventional non-selective NSAIDs, the synthesized compounds
did not contain any acidic group thereby ensuring possible freedom from ulcers. To further
substantiate the claim for safer derivatives, the active compounds were docked against cyclooxygenase
(COX)-2 enzyme. It was found that 4-fluorophenylimino substituent at 2- position and 3-nitro moiety
on 5-benzylidene nucleus of the 4-thiazolidinone derivative fitted in the COX-2 binding pocket. The
compounds exhibited remarkable activity in scavenging free radicals as depicted by DPPH assay method.
The structure-activity relationship was also established in the present work with respect to the nature
and position of the substituents. The active compounds were evaluated for drug-like nature under
Lipinski’s rule of five and the toxicity behavior of active compounds was predicted using ADMETlab
software. The compounds have the potential to target degenerative disorders associated with inflammation
and the generation of free radicals.
Severe Acute Respiratory Coronavirus-2: A Critical Review of Virus Biology, Genome and Pathophysiology
Authors: Agrawal Akhilesh , Kashikar Supriya , Deo kaivalya , Gaidhane Abhay , Bansod Anand , Jaiswal Priyanka , Khatib Mahalaqua Nazli
Published: July 2021

Severe Acute Respiratory Coronavirus-2 [SARS-CoV-2] emerged as a great threat to the world at the end of December 2019 in China. The SARS-CoV-2 evolved from a virus responsible for the SARS epidemic in 2002. The SARS-CoV-2 has a high rate of human-human transmission and originated from the bat. It has a close resemblance with bat-like-SARS-CoV compared to SARS-CoV; however, the Spike protein responsible for virus-host cell interaction possesses the least similarity with that of SARS-CoV. Cytokine Storm is associated with the severity of Covid-19 and leads to acute respiratory distress syndrome [ARDS] and/or multiple organ dysfunction syndromes [MODS]. In the current review article, the features of a novel coronavirus, including viral biology, genomic organisation, life cycle, pathophysiology and genetic diversity, have been discussed. The development of policies and plans which can prepare the world for future pandemics has also been proposed. In addition, the drug development pipelines, diagnostic facilities and management of such pandemics need an up-gradation to contain the current as well as future outbreaks.
Disinfection Measures during COVID-19 for Dental Operatories
Authors: Motwani Nidhi , Ikhar Anuja , Chandak Manoj , Gondivkar Shailesh
Published: July 2021

Background:

In the dental health-care setups, the environmental object and surfaces are expected to be infected by the COVID virus wherein definite procedures are performed. Consequently, these objects and surfaces, particularly where COVID-19 patients are being treated, must be appropriately cleaned and sanitized to stop further spread.

Objective:

The present article is intended for providing protocols about the cleaning and disinfection of objects and surfaces in the circumstances of COVID-19 for Dental operatories.

Methods:

Studies evaluating the surface characteristics of the virus as well as effective disinfection measures have been documented.

Results:

Various chemicals in different concentrations have a virocidal effect. The devices introduced include used UV radiation and ozone.

Conclusion:

These changes in dental clinical practice are needed to save humanity by preventing further transmission of disease.
Investigating the Knowledge of Sexually Transmitted Diseases in University Students of Iran
Authors: Vakilian Katayon
Published: July 2021

Background:

Unprotected sex, multi partnership, no or inconsistent use of the condom can be mentioned as risk behaviors putting youth at high risk to Sexually Transmitted Diseases (STDs). The present study aimed to investigate the knowledge of sexually transmitted diseases in the university students of Shahroud in Iran.

Methods:

This cross-sectional study was conducted in Shahroud city of Iran. 1500 female and male students in the age bracket of 18-24 were included in the study. Multistage sampling was employed. After stating the objective of the study, the questionnaire was distributed to students during the end of lecture time upon the agreement of the education officials and collected after 15 minutes. To ensure that the information provided will be kept confidential, the students were asked not to write down their names and fields of study. Data were described using descriptive statistics by SPSS software, version 20.

Results:

The answers showed that the female and male students have heard more about HIV (94.9% vs. 93.1%), gonorrhea (47.2% vs. 50.2%), genital herpes (45.6% vs. 33.1%), and genital warts (31.4% vs. 18.1%), in the order of frequency. 35.9% of females had no knowledge about the symptoms of diseases in women and 53% of males had no knowledge about the symptoms of the diseases in men. 26.6% of female students and 16% of male students knew regarding at least three symptoms of diseases.

Conclusion:

The present study showed that the university students' knowledge is far distant from the desired situation. This study succeeded in identifying the educational needs of the youth.
Post-Coronavirus Era: Should We Expect a Surge in Allergic Diseases and Asthma?
Authors: Nasab Entezar Mehrabi , Athari Seyyed Shamsadin
Published: July 2021

Some infectious agents by priming the immune system promote protection against allergy and asthma. During infections, Th1 immune responses are dominant, while in allergic conditions, Th2 responses are more pronounced. Th1 immune response protects the body against infections, and Th2 response leads to allergy and asthma. For maintaining health, the balance between Th1 and Th2 responses is necessary. The COVID-19 infection augments Th1 and also eosinophilic responses. On the other hand, the main protocols to control the COVID-19 pandemic require adherence to health standards, maintaining personal hygiene, frequent disinfecting of hands, using face masks, etc. In the post-COVID-19 era, this sterile condition may relinquish, and the Th1/Th2 immune imbalance may lead to an increase in the incidence of allergy and asthma. Therefore, focus on the COVID-19 infection should not deter us from foreseeing a surge in asthma and other post-coronavirus problems.
Routing and Treatment of Patients with Hematogenous Vertebral Osteomyelitis on the Tyumen Region Example
Authors: Bazarov A. Yu.
Published: July 2021

Background. Currently, various algorithms of tactical classifications and treatment regimens for hematogenous vertebral osteomyelitis (HVO) are proposed. However, all proposed approaches are designed for the treatment of patients in specialized multidisciplinary clinics departments, although the initial treatment often occurs in municipal polyclinics, private medical centers  and  district  hospitals.  The  question  is  what  the  appropriate  scope  of  diagnostic  and  therapeutic  measures  in institutions with different material and resource bases and how to ensure continuity according to the existing three-level system of medical care remains open. The aim of this studyis to determine the probable routing and treatment options for patients with HVO on the example of the Tyumen region, depending on the existing three-level system of providing medical care to the population.Object and Methods.The current Orders of the Ministry of Health of the Russian Federation and the Resolutions of the Government of the Tyumen Region were studied, on which basis a three-level system of providing medical care to the population was organized and organizations providing emergency and elective medical care to patients with HVO were identified. The volume of medical and diagnostic measures in patients with HVO in institutions of various levels, as well as their routing to the regional clinical hospital No. 2 in case of impossibility or inexpediency of providing specialized medical care at the place of primary treatment, is analyzed on the example of the Tyumen region. The clinical material is presented by 267 patients with HVO who were treated in the Tyumen regional clinical hospital No. 2 from 2006 to 2019, 78.7% of whom were treated in the profile of traumatology and orthopedics, 18.7% — neurosurgery and 2.6% — surgery. Results.The list of medical institutions that provide emergency and planned care in traumatology and orthopedics, neurosurgery in the Tyumen region is defined, depending on the level of the institution and the available material and resource base. A block diagram is proposed that determines the scope of medical and diagnostic measures in institutions of I-III levels and specialized departments of multidisciplinary clinical hospitals. The principle of determining the patient profile (surgical, orthopedic, neurosurgical) depending on the type and severity of the inflammatory lesion according to the classification E. Pola (2017) is proposed.Conclusion. The need for effective use of medical and diagnostic resources starting from level I is determined by clear routing of the patient to ensure the continuity of medical care. A full-fledged diagnosis is possible in institutions not lower than the third level with the mandatory determination of the lesion type and the severity of the inflammatory process. HVO treatment is advisable in level III institutions, specialized departments of regional clinical hospitals and federal institutions.
Minimally Invasive Approaches for Total Hip Arthroplasty: Systematic Review
Authors: Korytkin A. A. , Gerasimov S. A. , Kovaldov K. A. , Gerasimov E. A. , Pronskikh A. A. , Novikov A. V. , Morozova E. A.
Published: July 2021

Introduction. Main objective of total hip replacement (THR) is fast recovery of hip joint function and patient’s return to daily routines. Use of minimally invasive approaches (MIA) may help achieving set objective. The purpose of the study was to analyze and compare MIA in THR.Materials and methods. Databases of PubMed, Scopus, Cochrane Systematic Reviews, Google Scholar and E-library were searched for the period since 2000 to 2020. 55 scientific articles were selected for the analysis. Publications contain results of studies of MIA, such as Direct Anterior Approach (DAA), Micro-Hip (MH), Röttinger (R), Mini-posterior (MP), Direct Superior Approach (DSA), SuperCap (SC), PATH (P), SuperPATH (SP). The initial data were combined and underwent statistical processing.Results. A comparative analysis of MIA couldn’t identify superiority of any approach. Blood loss, length of hospital stay, functional outcomes (Harris Hip Score) at 3 and 12 months didn’t differ between the groups. Significant differences were found in the operation time between DSA and SP. Acetabular inclination was different between some approaches. Cup inclination in R and DSA, cup anteversion in DAA, MH and SP slightly exceeded Lewinnek's «safe zone». Recurrent dislocation, periprosthetic fractures, damage to the lateral cutaneous nerve are the most frequent postoperative complications.Conclusion: THR can be done using a variety of surgical approaches. The choice of approach relies on surgeon’s experience and personal preferences. Minimally invasive approaches have the advantage of short-term recovery due to the preservation of soft tissues.
Complications of Acute Acetabular Fractures Surgical Treatment: Systematic Review
Authors: Kolesnik A. I. , Zagorodniy N. V. , Ochkurenko A. A. , Lazarev A. F. , Solod E. I. , Donchenko S. V. , Solodilov I. M. , Ivanov D. A. , Ovcharenko A. V. , Surikov V. V.
Published: July 2021

Background.The combination of classical anterior and posterior approaches, as well as their modifications, is recognized as the most effective in acetabular fractures surgical treatment. The use of classical and modified approaches is accompanied by  serious  intra-  and  postoperative  complications  associated  primarily  with  the  duration  of  surgery,  significant  blood loss, tissue trauma, surgical site infection. The aim of review — to determine the main and most frequent complications associated with surgical approaches to the acetabulum. material and methods. Access to literature sources is carried out in the information systems and databases PubMed/Medline, Embase, Scopus, Сochran Library, eLibrary, Wiley Online Library. Keywords: acetabular fractures, surgical treatment, approach to the acetabulum, total hip replacement.Results. The most common intraoperative complications are incorrect fragments reduction, sciatic nerve injury, less often — intraarticular implant position, damage to the superior gluteal artery and other vessels, among the early postoperative complications - wound infection, both superficial and deep, less often — venous thrombosis. Late postoperative complications are mainly represented  by  the  development  of  heterotopic  ossification,  post-traumatic  coxarthrosis,  less  often  revealed  aseptic necrosis of the femoral head, residual protrusion and secondary femoral head lesion. Conclusion. The main approach to the acetabulum are the ileo-inguinal and the Kocher-Langenbeck approach, as well as their combination.Complications were more common using two approaches, especially in cases of simultaneous use. The main intraoperative complications are the sciatic nerve and the superior gluteal artery injury with posterior approaches, the femoral lateral cutaneous nerve with expanded ilio-femoral approach, and the obturator nerve with anterior approaches.
Efficiency of Surgical Debridement and Implant Retaining in Treatment of Early Postoperative and Acute Hematogenous Periprosthetic Infections of Hip
Authors: Tryapichnikov A. S. , Ermakov A. M. , Silantieva T. A. , Burtsev A. V.
Published: July 2021

Background. Periprosthetic infection is a devastating complication that influences the duration of treatment and patients life quality. Debridement, Antibiotics and Implant Retention (DAIR) is considered as least invasive surgery patients with stable  implant,  except  cases  of  chronical  periprosthetic  infection. The  aim  of  this  study was  to  evaluate  efficiency  of surgical debridement and implant retaining in control over infection in group patients with early postoperative and acute hematogenous periprosthetic infections. Materials and Methods.We performed retrospective monocentral cohort study of treatment early postoperative and acute hematogenous periprosthetic infections of hip in 26 patients. The group included cases with stable implants and period between manifestation of infection and DAIR no more than 4 weeks. We have classified infection as early postoperative in 22 patients (84,2%) and as acute hematogenous in 4 cases (15,8%). Results.At mean follow-up 42,8±2,3 mounts five patients underwent removal of implant due to reinfection. We performed successful twostage revision for four of them and had to perform resection arthroplasty in one case. Thus, DAIR protocol was successful in 80,8(%) cases. The mean Harris Hip Score significantly improved compared to preoperative values from 59,2±2,5 to 80,5±1,3 at the last follow-up (p = 0,0002, Z-3,7). Conclusions.The efficiency of DAIR according to our data was 80,8%. These results allow to consider DAIR as a method of treatment of patients with early postoperative and acute hematogenous periprosthetic infections. Exchange of modular components can decrease the reinfection rate.
Upper Limb Pathology in Children with Mucopolysaccharidoses
Authors: Kenis V. M. , Melchenko E. V. , Markova T. V. , Al Kaissi Ali , Sapogovskiy A. V. , Agranovich O. V. , Petrova E. V.
Published: July 2021

Background. Despite the success in the treatment of children with mucopolysaccharidoses (MPS) as a result of the widespread of  enzyme  replacement  therapy  and  hematopoietic  stem  cells  transplantation,  orthopedic  manifestations  continue  to  be a  significant  problem,  while  the  pathology  of  the  upper  limbs  in  children  with  MPS  is  not  sufficiently  represented  in  the literature. The aim of this studywas to analyze orthopedic and neurological manifestations in the upper extremities of children with  mucopolysaccharidosis  based  on  a  sequential  case  series. Materials  and  Methods. We  carried  out  a  comprehensive analysis of clinical and radiological involvement of the upper extremities in 49 patients with MPS. Results. The most common complaints reated to the upper extremities were difficulties in the daily activities (dressing, self-care, playing), impairment of the fine motor skills, and muscle weakness. The most frequent clinical manifestations related to the upper extremities were limited active shoulder abduction, impaired hand grip, flexion contractures of the elbow joint, ulnar deviation of the hand. All patients with MPS types I, II, and VI had limited active and passive extension and flexion of the metacarpophalangeal and interphalangeal joints. In patients with MPS IV, hypermobility of the hand joints prevailed. We noticed minimal presence of typical clinical manifestations related to compression of the median nerve secific for carpal tunnel syndrome. The majority of patients showed a decrease in tendon and periosteal reflexes. The most pronounced decrease in muscle strength was observed in to extensors (elbow, fingers) and shoulder abductors, which may contribute to the predominant formation of a flexion pattern of contractures. On radiographs of the hand, the “melting sugar” symptom and shortening of the metacarpal bones were observed in most patients. Conclusion.Clinical and radiological manifestations related to the upper extremities take  place  in  all  types  of  the  mPS,  and  lead  to  functional  disorders  that  complicate  daily  life  and  self-care.  Upper  limb pathology in children with MPS requires earlier detection and more active treatment after comprehensive risk assessment.
Minimally Invasive Arthroscopic Treatment of Patients with Medial Epicondylitis
Authors: Salikhov M. R. , Shulepov D. A. , Zlobin O. V. , Dmitrieva N. N. , Midaev A I.
Published: July 2021

Background. There  is  not  enough  research  on  the  topic  of  arthroscopic  treatment  of  medial  epicondylitis.  Topographic studies are needed to justify surgical approaches with minimal trauma to the medial collateral ligament and ulnar nerve. The aim of the study was to optimize the arthroscopic treatment of medial epicondylitis and evaluate its clinical effectiveness based on the results of the topographic and anatomical study. Materials and Methods. The material for the topographic and anatomical study was 12 «fresh» anatomical preparations of the human elbow joint, of which 6 were taken from female cadavers, and 6 — from men. The features of the structure and topography of the elbow medial collateral ligament were studied, and the safety and effectiveness of arthroscopic approaches to the elbow for the flexor carpi radialis release were determined. A prospective cohort comparative study was performed, which included 70 patients. Two comparative groups were formed. In the group I (35 patients) surgical treatment was carried out by the open method. The group II included 35 patients who underwent minimally invasive surgical treatment using arthroscopic technique. The results were evaluated by Mayo Elbow Perfomance Score (MEPS) and VAS before surgery and 1, 6, and 9 weeks after. Results. Functional results in 9 weeks: group I — 81.77 (95% CI 81.13; 82.41); group II — 92.66 (95% CI 91.61–93.70) points. The average score for VAS in the same period: group I — 34.30 (31.89–36.68) points; group II — 1.5 (0.46–2.45) points. Conclusion. The safe zone is located above the midline of the humeroulnaris joint by 2 (1.0–3.2) mm. The risk of the medial ulnar collateral ligament anterior bundle injury is minimal in this area. Treatment of patients with the medial epicondylitis according to the developed arthroscopic technique can significantly improve the patients functional state and quality of life.
The Effect of Three-Month Atorvastatin and α-Calcidol Administration on Some Bone Tissue Morphometric Parameters
Authors: Asachuk S. S. , Yakovleva O. S. , Martsinkevich A. F. , Karpenkа Е. A.
Published: July 2021

Background.Osteoporosis is the fourth most common disease after cardiovascular diseases, cancer, and diabetes. All these diseases  have  common  pathogenetic  mechanisms  associated  with  impaired  cholesterol  metabolism.  In  recent  decades, the  use  of  the  key  enzyme  of  cholesterol  synthesis  inhibitors —  statins,  which  can  stimulate  osteogenesis,  has  become widespread. However, statins affect the production of the vitamin D active form by reducing the production of testosterone and thus reducing the activity of 1α-hydroxylase. The combined use of statins and α-calcidol (α-C) for the osteoporosis prevention  seems  promising. The  aim  of  the  study was  to  evaluate  the  effect  of  long-term  atorvastatin  (ATV)  and α-C administration on morphometric growth parameters and bone vascularization in the experiment.Materials and Methods. The experiment was conducted for three months on 120 laboratory male rats, which were injected daily intragastrically with ATV and α-C. After 90 days of the experiment, the animals were decapitated under ether anesthesia. For the study, the right femur and jawbone were taken from the animals. The rat bone sections were impregnated with silver, decalcified, and the histosections were stained according to van Gieson. The distribution of the studied features was evaluated according to the Shapiro-Wilk test. The differences were considered statistically significant at p0.05.Results.It was found that ATV, both separately and together with α-C, increased the size of the newly formed bone in the endoostal and periosteal zones of the femur by 64.8; 40.4 and 15.8; 29.1%, respectively. The combined use of ATV and α-C had a positive effect on the growth of blood vessels in the femur (+23.4%). ATV increased the size of the newly formed bone from the periodontal and vestibular surfaces of the lower jaw by 18.3 and 29.5%, respectively. α-C potentiated the effect of ATV on the size of the newly formed bone tissue in the periodontal and vestibular growth zones of the mandibular bone by 10.1 and 15.0%, respectively. As for the number of vessels in the jawbone tissue, thanks to ATV, it increased by 17.2%, α-C had no effect.Conclusion. ATV increases the thickness of the newly formed bone layer in the growth areas of the femur and jawbone and increases the number of vessels in the jawbone. α-calcidol increases the number of vessels in the bone tissue of the femur and potentiates the effect of ATV on the jawbone growth zones. The combined use of ATV and α-C shows that they positively complement each other.
The Optimal Surgical Needle for Tendon Suture: Cutting Edge or Reverse Cutting Edge?
Authors: Zolotov A. S. , Isokov S. Kh. , Isokova A. Kh.
Published: July 2021

Background. Achieving  a  durable  connection  between  the  lacerated  tendon  ends  is  difficult.  The  outcome  of  treatment depends on many factors. Several authors consider the properties of the surgical needle used for suturing the tendon to be important. The aim of the study— to compare the strength of the tendon suture applied with the conventional cutting edge and reverse cutting edge surgical needles in the experiment.Materials and Methods.We used porcine tendons for the experiment. The tendon fragments were divided into 2 groups of 20 tendons each. On all 40 tendons, the same type of “injury” of the tendon was simulated — using a scalpel. In the first group, the interrupted suture of the tendon was applied with a cutting edge surgical needle, in the second group — reverse cutting edge. Laboratory tests of the tendon sutures strength were performed on the improvised stand.Results.In the first (suture made with a cutting needle edge), diastasis of 2 mm was determined at an average load of 1219.5 g (m = ±76.56, where «m» is the representativeness error). Complete suture failure occurred at an average load of 1770.8 g (m = ±100.02). In this group, the thread rupture was not recorded. In the second group (a suture made with a reverse cutting edge needle), diastasis occurs with an average load of 1754.75 g (m = ±77.32). Complete suture failure occurred at an average load of 2571.25 (at m= ± 103.78). In three cases, the thread ruptured. In the second group (reverse cutting edge needle), the tendon suture strength was statistically significantly higher than in the first group. Conclusion. The tendon suture strength depends on the surgical needle properties. In tendons  reconstruction  the  reverse  cutting  edge  needle  use  is  more  preferable  compared  to  the  conventional  cutting  edge needle use.
Morphometric Parameters of Lower Leg Tissues and Their Correlation with Laboratory Data in Patients with Post-Traumatic Osteomyelitis
Authors: Grigorovskiy V. V. , Gritsay N. P. , Tsokalo V. N. , Lyutko O. B. , Grigorovskaya A. V.
Published: July 2021

Background. Knowledge  about  the  pathological  processes  in  the  tissues  of  the  limb  is  necessary  for  the  targeted optimization of their course, the expectation of certain treatment results. The aim of the study was to determine the ratio of different severity cases and the correlation between individual clinical, laboratory and morphometric indicators of the tissues state in patients with trophic disorders in the extremity.Materials and Methods.The material was fragments of the lower leg tissues (bones, soft tissues, skin) of 38 patients with chronic post-traumatic osteomyelitis. Gradation morphometric  indicators  reflecting  the  tissues  state  in  the  lesion  focuses  were  used.  Frequency  analysis  of  semiquantitative indicators and correlation analysis of the relationships between clinical, laboratory and morphometric indicators with the evaluation of the association coefficient were carried out. Results.Trophic disorders in the limb tissues (bones, soft tissues, muscles, skin), observed in patients with lower leg bones post-traumatic osteomyelitis, do  not  represent  a  group  of  well-defined  pathological  processes.  They  form  a  complex  of  dyscirculatory,  ischemic, necrotic, dystrophic, atrophic, inflammatory, reparative and regenerative changes, which are combined in tissues in different proportions. This involves the use of a number of quantitative and semi-quantitative, gradation indicators: clinical, laboratory, and pathomorphological. Pathomorphological changes in the lesions in patients with chronic posttraumatic osteomyelitis of the lower leg bones with clinical signs of trophic disorders do not differ qualitatively from the changes usually detected in chronic post-traumatic osteomyelitis. In the bones, the most frequent are destructive focuses with a predominance of exudative and productive inflammation of high activity, sequestration and osteonecrosis. In paraossal soft tissues, more common are focuses, in which mature fibrous tissue and productive inflammation of low activity predominate. In the skin near the chronic post-traumatic osteomyelitis focuses, there is dermis fibrosis and productive inflammation of low activity.Conclusion. A number of correlations between clinical and laboratory parameters, on the one hand, and morphological parameters, on the other, have been established. The closest and most stable connections for different sites are the following indicators: blood leukocytes (negative dependence for affected bone, soft tissue and skin tissues), ESR (positive dependence for soft tissues), C-reactive protein (positive dependence for soft tissues and skin), agglutination with a polyvalent strain of Staphylococcus aureus (negative dependence for affected bones and skin).