bluuebunny/crossref_metadata_2025 huggingface dataset:
БІОАКТИВНІ СПОЛУКИ ЕКСТРАГОВАНІ ІЗ ТРАВИ SPERANSKIA TUBERCULATA (BUNGE) BAILL
Authors: Сунь Цзеюань , Деркач Тетяна М.
Published: November 2024

Мета. Ідентифікація біоактивних сполук в препаратах, екстрагованих із трави Speranskia tuberculata із застосуванням двох різних розчинників, та порівняння впливу екстрактів на ракові клітини людини чотирьох різних ліній. Методи. Сирі екстракти готували шляхом екстрагування із застосуванням етилацетату або петролейного ефіру з наступною відгонкою, сушкою і приготуванням робочих розчинів на основі диметилсульфоксиду в діапазоні концентрацій 12.5–75 мкг/мл. MTT тести використані для визначення впливу коцентрації препаратів на життєздатність ракових клітин чотирьох комерційно доступних ліній: A549 (аденокарцинома легень), HEPG2 (гепатоцелюлярна карцинома печінки), A375 (злоякісна меланома), HELA (карцинома підшлункової залози). Використано тандемний метод рідинної хроматографії-мас-спектроскопії (LC/MS) для ідентифікації основних сполук та порівняння складу обох екстрактів. Результати. Обробка розробленими препаратами знижувала життєздатність всіх 4 типів ракових клітин. Етилацетатні екстракти завжди є більш ефективніими. IC50 етилацетатного екстракту для всіх клітинних ліній варіювався в межах 49–53 мкг/мл. У препаратах ідентифіковано приблизно 100–200 сполук, причому їх кількість в екстрактах петролейного ефіру була приблизно вдвічі вища. Концентрації 11 сполук суттєво зростають під час переходу від екстрагування петролейним ефіром до етилацетату. На ґрунті літературних даних проаналізовано потенціал біологічної активності ідентифікованих сполук. Висновки. Досліджувані препарати знижували життєздатність різних ракових клітин людини. Препарати, екстраговані етилацетатом, були ефективнішими відносно всіх типів клітин. Сотні сполук ідентифіковані в екстрактах; обговорена протиракова дія деяких.
ВИЛУЧЕННЯ КОЛЬОРОВИХ МЕТАЛІВ ІЗ ВОДНИХ АМОНІЙНИХ РОЗЧИНІВ
Authors: Кельбалієв Гудрат І. , Шекілієв Фікрет І. , Гасан Ірада Мелікова
Published: November 2024

Робота присвячена вилученню кадмію з аміачних водних розчинів. Досліджено взаємодію кадмію з 2-гідрокси-5-алкілбензилетилендіаміном у широкому інтервалі рН. Визначено склад екстрагованих сполук. Показано, що стан кадмію в аміачних розчинах залежить від значення рН середовища, а також від концентрації іонів амонійної солі. Встановлено, що кадмій в проведених реакціях знаходиться в амінних формах – [Cd(NH3)4]2+. У цьому випадку екстрагент координується з іоном кадмію через атоми кисню фенольної ОН-групи та амінної групи азоту. Підтвердженням взаємодії кадмію з реагентом в результаті обміну протоном фенольної групи OH та координації молекулами групи NH, можуть слугувати результати ІЧ-спектроскопічного дослідження реагенту та екстрагованого комплексу в CCl4, зняті в області 700–4000 см-1, характерні для появи ν-коливань гідроксильних та NH-зв’язків в молекулах екстрагованої сполуки. ІЧ-спектри реагенту та екстрагованої сполуки кадмію показують, що характерна смуга поглинання ОН-групи в молекулі фенолу за довжини хвилі 3590 см-1 різко зменшується, що свідчить про заміщення протона гідроксильної групи на іон екстрагованого металу та утворення зв’язку Cd-O. Крім того, смуга поглинання NH-зв’язку за 1640 см-1 в комплексі зміщується в короткохвильову область спектра, що також свідчить про участь NH-групи в утворенні комплексу. Ці аналізи допомогли встановити, що іон кадмію в комплексних сполуках дійсно зв’язаний водневим зв’язком з молекулами і утворює тетраедричну геометрію.
Az online hírek terjedésének szerepe a Covid–19-járvány elleni védekezésben
Authors: Igari András
Published: November 2024

Tanulmányomban arra kerestem a választ, hogy vajon miként segíthette a Covid–19-járvány első hulláma elleni védekezést az online hírek terjedése Európa országaiban. A járványterjedéshez és a Google-felületén való keresésekhez kapcsolódó adatok tér-időbeli elemzése során azt kaptam, hogy a Covid–19-ről szóló információk a járványnál gyorsabban terjedtek el az interneten. Ennek köszönhetően a két terjedési hullám közötti időeltolódás országonként eltérő volt: az információs hullámhoz képest a járványhullám viszonylag később érte el Kelet-Közép-Európát, mint a kontinens többi részét. Ez több időt adott a felkészülésre, a szükséges korlátozások meghozására, így elősegíthette a pandémia terjedésének lassítását és a halálozások számának mérséklését a térségben.
INSURGES DE L’EMPIRE: LIVRES QUI ENSEIGNENT PARAIBA (1817-1930)
Authors: Stamatto Maria Inês Sucupira , Engler Cury Cláudia
Published: November 2024

Dans cet article, nous cherchons à comprendre le processus d’émergence des livres scolaires régionaux au Brésil. Nous prenons Paraíba comme référence. Nous délimitons l'étude comme une section thématique du projet de recherche sur les livres scolaires publiés au Brésil au XIXe siècle et dans les premières décennies du XXe siècle, développé dans le cadre du Groupe de recherche sur l'histoire de l'éducation au nord-est du XIXe siècle. – GHENO/UFPB. La principale source était le Livre scolaire, notamment le Livre scolaire régional. Nous avons effectué des recherches bibliographiques et catalogué les manuels scolaires régionaux d'Histoire et de Géographie. Des recherches sur le terrain ont été menées dans les collections de la Bibliothèque des Archives publiques de l'État de Paraíba et de la Fundação Casa de José Américo. Les Histoires des Provinces ne trouvent pas d’espace pour se consolider dans l’historiographie brésilienne de l’Empire. Ce serait avec la République fédérative, lorsque les oligarchies régionales commenceraient à contrôler le gouvernement fédéral, que serait l'incitation à la production historiographique locale.
Barriers and Facilitators to Cycling to School for Children in the UK: A Systematic Review
Authors: Boland Paul , Nowland Rebecca , Tellis Kennedy Dominic , Adams Mags , Westwood Joanne , Crook Deborah , Larkins Cath , Ridley Julie
Published: November 2024

The benefits of cycling as a means of active transport are well known, and there is recent UK Government interest in promoting cycling. Few children in the UK cycle to school, and little research has explored the factors that affect this.This systematic review aimed to identify the barriers and facilitators for children cycling to school in the UK.
We searched seven electronic databases and grey literature for sources, from 2010 onwards. In total 16 papers/articles were included. The capabilities approach (CA) was used as a framework for analysis to identify personal, social, and environmental barriers and facilitators. Personal barriers and facilitators centred around gender and age, but also related to concerns about safety or confidence. Social barriers and facilitators related to parental attitudes and wider social norms. Environmental barriers included distance, infrastructure, and deprivation. Using the CA revealed the complex interweaving of factors that must be addressed by interventions seeking to promote children’s cycling to school. For example, parental fears about children’s safety when cycling are linked to prevailing social norms and to local cycling infrastructure. Local authorities can promote cycling by developing well-connected accessible and safe cycle routes, but this alone is likely to be insufficient. Schools can enhance personal, social, and environmental conver-sion  factors  by  developing  and  implementing  active  transport  plans,  increasing children’s personal competences, reassuring parental fears, and providing secure storage and changing facilities. Further research exploring how barriers can be addressed, together with local and national policies and targeted funding which focus on facilitation of cycling to school are warranted.
Simulation of the radio absorbing properties of pyrolyzed polyacrylonitrile in the frequency range from 3 to 50 GHz
Authors: Radchenko D. P. , Zaporotskova I. V. , Kozhitov L. V. , Zaporotskov P. A. , Popkova A. V. , Kosushkin V. G.
Published: November 2024

Currently, the electromagnetic characteristics of various materials, including polymers, are being widely studied with the aim of using them as radio-absorbing coatings in electronics products. One such material is pyrolyzed polyacrylonitrile (PPAN). A model of electromagnetic wave absorption by PPAN layers with electrical conductivity of 72 and 180 S/m and a layer width of 0.15 to 2 mm, including those containing a metal filler (the so-called PPAN-based metal composite), in the frequency range of 3–50 GHz is considered. The simulation was performed in the COMSOL Multiphysics software package.

A comparison of the experimental results with the data obtained during the simulation was carried out for such parameters as reflection, transmission and absorption. The conclusions obtained from the analysis of simulation data coincide with the results of practical experiments. Analysis of the model showed the convergence of modeling results with experimental data at a qualitative level.
On the relevance of the problem of synthesis of new materials in the conditions of innovative industrial development
Authors: Zatsarinnyy A. A. , Abgaryan K. K.
Published: November 2024

The article discusses current problems of the synthesis of new materials in modern conditions. It is noted that today this is the most important strategic task of innovative development of Russian industry. The factors determining the relevance of this task are formulated. A brief analysis of the state of Russian microelectronics is given. The importance of mathematical modeling methods and the need to develop innovative approaches in the field of synthesis of new materials are shown. The main directions of scientific research related to the development of new model concepts, methods and algorithms used in the field of mathematical modeling of the structures and properties of nanomaterials, as well as systems based on them, discussed at the IV International Conference “Mathematical Modeling in Materials Science of Electronic Components” (ICM3SEC-2022). The paper shows that for the further development of methods and means of mathematical modeling, a domestic high-performance environment for scientific research is required, with a comfortable user interface, flexibility in setting up resources, high performance and reliability.
Role of Vermicompost and algae Extract in Improving Growth and Fruit Quality of Mango (Keitt)
Authors: Mustafa NS , Ashwaq M Alnemari , Eman S El-Hady , Mohamad F El-Dahshouri , M A Hassoub , Yasser Thabet A Moustafa , IM El-Berry
Published: November 2024

This research, spanning the 2021 and 2022 seasons, aimed to explore the impact of vermicomposting on the growth and productivity of Mango trees (cv. Keitt) cultivated in sandy soil at Ahmed Orabi Agricultural region, El-Obour City, Cairo Governorate, Egypt. The selected trees underwent various treatments, including water (control), vermicomposting at 1 or 2 Kg/tree, Spirulina platensis algae extract at (5 or 10ml/l), and their combinations. Optimal results in terms of leaf fresh and dry weight, leaf area, and chlorophyll content were observed with the treatment of 2kg vermicompost + 10ml/l algae extract. Furthermore, the addition of vermicompost along with algae extract improved the leaf status of N, P, K, and Ca. Application of both vermicompost and algae extract, whether individually or in combination, demonstrated positive effects on the physicochemical quality of the fruit. The findings suggest that the simultaneous use of vermicompost and algae extract holds promise as a supplementary material for enhancing the growth, productivity, and fruit quality of Mango trees.
The significance of individual patient characteristics in a cohort of patients with inflammatory bowel disease treated with vedolizumab
Authors: Zubčević Nadža , Bašić-Denjagić Mirela , Babić Emil , Barač Tatjana , Saray Aida , Čustović Nerma
Published: November 2024

Aim Care for the inflammatory bowel disease (IBD) patients presents unique challenges as decisions regarding therapy must consider numerous distinct characteristics of each patient. The aim of the study was to recognize patients’ characteristics as predictors of success in vedolizumab treatment.
Methods In a retrospective observational study, data regarding age, gender, body mass index (BMI), length of disease, previous exposure to anti-tumour necrosis factor (TNF), drugs, and smoking status were extracted from the routine clinical practice. Patients were assessed for clinical remission and steroid-free remission after the 26-week treatment with vedolizumab.
Results The study included 76 patients with UC and 63 with CD. A total of 63 (out of 76; 
82.9%) (Cl: 72.5-90.6% ) of UC and 54 (out of 63; 85.7%) (Cl: 74.6-93.3%) CD patients achieved clinical remission in the 26-week vedolizumab treatment. Over five years, illness was noticed in 32 (53.1%) CD patients. Clinical remission was not achieved in six (out of 13; 46.1%) UC patients aged 40-49 years and six (out of nine; 66.6%) CD patients aged 30-49 years. Among CD patients, remission was achieved in 22 (85.7%) females and 23 (63.6%) males. Remission rates were generally higher in patients with a BMI of 18.6-25 and 25.1-30. Previous exposure to anti TNF drugs and smoking status did not influence treatment outcomes.
Conclusion The efficacy of vedolizumab is a viable treatment option for both ulcerative colitis and Crohn's disease. The exploration of individual patient characteristics holds promise in predicting a treatment outcome.
Heart and kidney crosstalk: risk factors, clinical features, and short-term outcomes associated with acute kidney injury in patients suffering acute non-ST elevation myocardial infarction
Authors: Becirovic Minela , Bećirović Emir , Hadžić Semir , Rakovac Tupković Lejla , Bećirović Amir , Avdić Jahić Nadina , Ribić Aida , Ferhatbegović Lamija , Jagodić Ejubović Amira , Begagić Emir , Lončar Daniela , Ljuca Kenana
Published: November 2024

Aim Acute kidney injury (AKI) presents a high mortality complication in patients with acute myocardial infarction (AMI). Yet, its correlation with non-ST elevation myocardial infarction (NSTEMI) remains neglected in the literature. This study aims to investigate the prevalence, risk factors, clinical features, and short-term outcomes associated with AKI development in patients with acute NSTEMI.
Methods A one-year prospective observational cohort study involved 170 consecutive patients hospitalized in the Intensive Care Department of the Internal Medicine Clinic at the University Clinical Centre Tuzla diagnosed with acute NSTEMI. Patients were subsequently categorized into AKI and non-AKI groups based on AKI development within 48 hours. Demographic characteristics, laboratory findings, and short-term clinical outcomes were compared between the groups.
Results Of 170 patients, 31 (18.2%) developed AKI within 48 hours of acute NSTEMI. Significant age differences, blood urea nitrogen (BUN), creatinine, estimated glomerular filtration rate (eGFR), blood glucose level (BGL), C-reactive protein (CRP), and high sensitivity (hs) troponin were observed, making patients with lower baseline kidney function, more extensive myocardial infarction, and a heavier systemic inflammatory response following acute NSTEMI more susceptible to AKI development. In the follow-up period, mortality rates were significantly higher in the AKI group, amounting to 35.5% compared to 10.1% in the non-AKI group. Additionally, mortality increased with the severity of AKI, reaching 100% in AKI stage 2.
Conclusion This study highlights demographic, clinical and laboratory findings in patients with acute NSTEMI, which contribute to AKI development. Early detection and tailored interventions are crucial in mitigating AKI-associated morbidity and mortality.
Predictive factors for biochemical relapse in non-metastatic prostate cancer following primary radiotherapy
Authors: Kovčić Amila , Umihanić Šefika , Osmić Hasan , Muhić Almedina , Trumić Enida , Hamzić Eldar , Becirovic Emir , Hadžić Semir , Bećirović Amir , Becirovic Minela , Begagic Emir
Published: November 2024

Aim To investigate the predictors of biochemical relapse (BCR) among patients with non-metastatic prostate cancer treated with radiotherapy as the first-line therapy. 
Methods The study included 91 patients diagnosed with prostate cancer at the University Clinical Centre in Tuzla, Bosnia and Herzegovina. After the radiation treatment as the first line of treatment, the patients were monitored for the next 36 months. If patients were classified in medium and high-risk groups, hormone therapy was administered. The occurrence of BCR was determined based on prostate-specific antigen (PSA) values. Potential prognostic parameters, including Gleason score (GS), PSA, tumour size (TNM), and standardised risk classification (RC), were monitored.
Results A total of 46 (50.5%) patients were aged 66-75, with a median PSA of 14.50 ng/mL. A Gleason score <6 was found in 72 (79.1%) of patients, and 31 (34.1%) had T2c tumours. The BCR occurred in 32 (35.2%) patients, with a median relapse time of 18 months. Significant predictors of BCR were Gleason score ≥6 (OR:4.46; p=0.006) and tumour stage >T2b (OR:3.59; p=0.021). The RC showed an Area Under Curve (AUC) of 0.634 (p=0.050), indicating its potential diagnostic accuracy.
Conclusion Gleason score ≥6 and TNM>T2b are significant predictors of biochemical relapse in prostate cancer patients treated with radiotherapy. These results emphasize the need for additional monitoring and timely treatment of clinical disease progression in patients with Gleason score ≥6 and tumour stage >T2b.
Can the APACHE II score be used to assess the risk of mortality in the elderly with hip fractures?
Authors: Bujakovic Tarik , Delibegovic Samir
Published: November 2024

Aim Various predictive models have been developed to help identify patients with hip fractures with greater or lower probability of survival. The aim of this study was to establish the capacity of the APACHE II score to predict the survival of patients with hip fracture, in people aged over 65 years, and compare it with the existing score used to predict the survival of these patients. 

Methods This was a prospective, cohort study conducted in a tertiary care teaching hospital including 410 consecutive patients with hip fracture aged ≥65 years. As part of the preoperative preparation, general health of the patients was classified according to the ASA score. The Charlson Comorbidity Index (CCI), the Nottingham Hip Fracture Score (NHFS), the POSSUM-P and the APACHE II scores were analysed. 

Results The sensitivity and specificity of the P-POSSUM score were 78.3 and 73.0, respectively, which was better than the APACHE II whose sensitivity and specificity were 56.6 and 89.7. The area beneath the ROC curve for P-POSSUM was 0.809, and for APACHE II, 0.803. However, there was no statistically significant difference between the APACHE II and P-POSSUM scores. The P-POSSUM and APACHE II scores were statistically significantly better than ASA, the Nottingham score and CCI. 

Conclusion This study showed that POSSUM-P and APACHE II can be used to predict mortality in elderly people with hip fractures. 
Approaches to rhythm control: Impact of electrical cardioversion versus pharmacological management on left atrial size and systolic performance in atrial fibrillation and flutter
Authors: Bećirović Emir , Bećirović Minela , Bećirović Amir , Tupković Rakovac Lejla , Jagodić Ejubović Amira , Čaušević Begajeta , Ejubović Malik , Ribić Aida , Ferhatbegović Lamija , Brkić Ammar , Hadžić Semir , Skokić Maida , Begagić Emir
Published: November 2024

Aim To compare the impact of electrical cardioversion (ECV) and pharmacological cardioversion (PCV) on left atrial size (LA) and left ventricular ejection fraction (LVEF), as well as to identify predictors of rhythm disorder recurrence in patients with atrial fibrillation (AF) or atrial flutter (AFL).
Methods A prospective observational cohort study was conducted on 105 patients with persistent AF or AFL at the University Clinical Centre Tuzla. The patients were divided into two groups: 53 underwent ECV and 52 received PCV. Demographic and clinical data, including ECG and transthoracic echocardiography, were collected. Follow-up assessments were conducted at 7 days, 1 month, and subsequently every 3 months for a year.
Results Baseline characteristics were similar between the groups. Recurrence of rhythm disorder within one year was observed in 52.4% of cases, with ECV showing a slightly lower, though not significantly different, primary failure rate at 7 days compared to PCV (13.2% vs. 23.1%). Significant predictors of recurrence included longer duration of disorder (p<0.001), hypertension (p=0.016), lack of pre-cardioversion amiodarone (p=0.027), and larger LA (p<0.001). Both ECV and PCV significantly reduced LA over time, with no significant differences in LVEF between groups.
Conclusion Both ECV and PCV are effective in restoring sinus rhythm, with a trend towards lower recurrence in the ECV group. Predictors such as disorder duration, hypertension, lack of pre-cardioversion amiodarone, and LA should be considered when planning cardioversion to optimize patient outcomes.
Risk Factor Analysis and Predictive Model Development for Problematic Internet Gaming Disorder Occurrence
Authors: Kusumadewi Andrian Fajar , Hananto Raihan , Amalia Arrum Putri , Hertanto Muhammad Dicky , Sihageng Hermanuaji , Diandraputra Muhammad Jordan
Published: November 2024

Aim To examine several aspects, such as sociodemographic, psychological, personality, and parenting characteristics, that may contribute to the occurrence of PIGD in Yogyakarta, Indonesia. Additionally, the study intends to create a model that can accurately predict people who are at high risk of developing PIGD. 

Methods. A cross-sectional study was conducted on 350 participants aged 15-25 years in Yogyakarta. The data was gathered through the use of a questionnaire that consisted of demographic measures: the Internet Gaming Disorder Scale—Short Form (IGDS9-SF), the Depression Anxiety Stress Scale (DASS-21), the Big Five Inventory (BFI), and the Parenting Style Questionnaire. Multiple logistic regression was utilized for data analysis in order to identify relevant risk factors and construct a risk prediction model.

Results. The study revealed that certain sociodemographic characteristics (male and student), psychological factors (depression, anxiety, and stress), personality traits (high neuroticism, low conscientiousness), and authoritarian parenting style were all significant predictors of the occurrence of PIGD. These characteristics led to the creation of the risk prediction model, which demonstrated strong performance with an area under the curve (AUC) of 0.85 (95% CI 0.80-0.90).

Conclusion. Multifaceted issue and variety of risk factors influence PIGD. This study's risk prediction model can effectively identify individuals at a heightened risk of developing PIGD. This allows for early and targeted preventative and treatment interventions to be implemented.
Effect of Arabic Gum on Gentamicin Nephrotoxicity in Mice: A Pathological Study
Authors: Alhyali Liqaa , Abed Firas , AL-Kenanny Entisar
Published: November 2024

Aim To investigate the effect of Arabic gum on gentamycin nephrotoxicity in mice kidney.
Methods Forty (40) mice were divided into five groups, eight mice in each. Group one (G1) stands for the negative control group. The second one (G2) was injected with gentamycin only, while the third one (G3) was given an Arabic gum orally 10g/kg. The 4th group (G4) was injected with gentamycin for 8 days, and then followed by Arabic gum orally for 8 days. The fifth group (G5) was injected with gentamycin plus oral administration of Arabic gum at the same time. A scoring system (+1-+4) was used to grade the histological features in the kidneys.
Results The results revealed a significant increase in body weight in G3 group only; this group presented a significant decrease in the level of both urea and creatinine. Group G2 showed a marked elevation in both serum urea and creatinine. Acute tubular necrosis (+4), in both G2 and G5. In G3, kidney sections presented mild cell swelling of the tubular epithelium in addition to the normal architectures (score +1), while G4 sections revealed tubular hyalin cast, expansion of glomerular tufts.
Conclusion The research indicates that gentamycin leads to kidney damage in mice. Arabic gum could be a treatment option although additional studies are required to determine the best dosing and timing, for optimal effectiveness.
Coexistence of aerobic vaginitis caused by Enterococcus faecalis and human papilloma virus (HPV) infection as a risk factor for the development of cervical intraepithelial lesions
Authors: Baraković Amna , Jahić Mahira , Cerovac Anis , Numanović Fatima
Published: November 2024

Aim To determine the prevalence of aerobic vaginitis (AV) caused by Enterococcus faecalis (E. faecalis) in human papilloma virus (HPV)-positive women with pathological Pap test and to determine the most prevalent HPV type associated with E. faecalis infection.
Methods This prospective study was conducted at the Gynaecology Centre "Dr. Mahira Jahić" Tuzla and Primary Health Care Centre Tešanj (Bosnia and Herzegovina) in the period between February 2023 and March 2024. The research included 200 women aged 25 to 50 years. The examined group consisted of 100 women with a pathological (examined group) and 100 with a normal (control group) Pap test result.
Results Pathological Pap smears were found in 60 (out of 100; 60 %) women in the examined group: cervical intraepithelial neoplasia (CIN) 1 and CIN 2  in two women, respectively, CIN 3 in seven, atypical squamous cells of undetermined significance (ASCUS) in 29 and atypical squamous cells-high-grade cannot be excluded (ASC-H) in two women. Overall (both groups) prevalence of E. faecalis was 25.5% (51women); in 45 (22.5%) women E. faecalis was the only bacterial isolate, of which 42 (21%) in the examined group and three (1.5%) in the control group. High-risk HPV types were found in 62 (out of  100; 62%) women with the pathological Pap smear test. The association of E. faecalis and high-risk HPV positive women was found in 35 (35%) cases (moderately positive correlation; r=0.198).
Conclusion E. faecalis is very common in HPV 16 and 18 positive women and may represent a risk factor in the development of cervical intraepithelial lesions.
Lower urinary tract symptoms (LUTS) as a clinical feature of lumbar spinal stenosis (LSS): a prospective study with lumbar spine morphometry analysis
Authors: Hodzic Harun , Bečulić Hakija , Begagic Emir , Huseinspahić Nejla , Sladojević Igor , Popov Andrej , Iriškić Rasim , Zulović Tarik , Becirovic Emir , Lakičević Goran , Nuhović Adem , Sefo Haso , Jusić Aldin , Radovanović Jovana
Published: November 2024

Aim To investigate clinical and morphometric characteristics of patients with lower urinary tract symptoms (LUTS) due to lumbar spinal stenosis (LSS).
Methods This study evaluated LSS patients using clinical assessments of motor, sensory, bladder, and bowel functions, and functional disability scores from the Oswestry Disability Index (ODI) and Swiss Spinal Stenosis Questionnaire (SSSQ). Morphometric analysis included MRI measurements of the anteroposterior diameter of the intervertebral disc and dural sac, and the modified Torg-Pavlov ratio (mTPR), with follow-up re-evaluations at 6 months.
Results Of 159 patients, 49 (30.8%) had LUTS and 110 (69.2%) were in the control group. LUTS patients had a significantly higher prevalence of neurogenic claudication (100% vs. 47.3%; p<0.001), lower back pain (93.9% vs. 77.3%; p=0.011), and lower extremity pain (57.1% vs. 34.5%; p=0.008). The LUTS group also had higher ODI (54.0 vs. 50.0; p=0.019) and SSSQ score (44.0 vs. 34.0; p<0.001). Morphometric analysis showed significantly lower mTPR in LUTS patients (median 0.31 vs. 0.45; p<0.001), with an AUC of 0.704 (95%CI 0.627-0.774). mTPR≤0.31 predicted surgical revision within 6 months (OR:3.4, CI: 1.2-9.8), motor deficiency (OR:2.1, 95%CI: 1.4-5.2), and persistent LUTS post-surgery (OR:4.5, 95%CI: 1.1-18.9). mTPR≤0.34 was associated with worse follow-up outcome, including increased ODI (β:3.2; 95%CI: 1.1-5.3; p=0.004) and SSSQ score (β:4.8; 95%CI:2.1-7.5).
Conclusion LUTS patients with LSS exhibit more severe symptoms and poorer outcome, with mTPR≤0.34 being a predictor of adverse clinical outcome and the need for surgical revision within 6 months.
Bariatric surgery in University Clinical Centre Tuzla and Bosnia and Herzegovina: where we are and where we want to be
Authors: Pašić Fuad , Salkić Nermin , Ahmetašević Emir , Alibegović Ervin , Smajić Jasmina , Jašarević Lejla , Softić Rusmir , Hamidović Jasmin , Krupalija Amina
Published: November 2024

Bariatric surgery has emerged as the most effective treatment for morbid obesity, offering substantial and sustained weight loss and improvement in comorbid conditions. This paper reviews the development, implementation, and outcomes of bariatric surgery at the University and Clinical Centre Tuzla based on a retrospective analysis of patients who underwent bariatric surgery over a three-year period. A significant weight loss was observed, postoperative complications were minimal, with no in-hospital mortality. The bariatric surgery program demonstrates a significant progress in treating morbid obesity in Bosnia and Herzegovina.
Which accessible clinical features and laboratory findings might predict methotrexate success in children with juvenile idiopathic arthritis in Bosnia and Herzegovina?
Authors: Čengić Adisa , Selmanović Velma , Hasanbegović Sniježana , Izeta Hamza , Zečević Lamija , Džananović Nejra
Published: November 2024

Aim To determine whether demographic data, clinical features, and laboratory variables at disease onset can predict the response to methotrexate in juvenile idiopathic arthritis (JIA) patients. 
Methods A cohort of 143 newly diagnosed JIA patients initially treated with methotrexate was enrolled in this study. Demographic, clinical, and laboratory parameters were analysed using univariate and multivariate logistic regression to identify predictors of response to methotrexate. The variables included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelets, IgA, IgG, the number of active joints and age at disease onset. Treatment response was assessed at six months, with patients classified as responders (those who achieved clinically inactive disease according to the American College of Rheumatology - ACR criteria) or non-responders. 
Results Poor response to methotrexate was associated with the number of active joints (p=0.0001; OR=2.7), baseline levels of CRP (p=0.044; OR=1.138), IgA (p =0.004; OR=2.159), and platelet count (p=0.01; OR=1.05). IgG level (P=0.236) did not correlate with the treatment response. 
Conclusion We identified widely available and clinically acceptable biomarkers that can be utilized as predictive indicators of response to methotrexate in JIA patients.
Features and complexity of treatment of BRCA-associated ovarian cancer, chronic disease: literature review
Authors: Gorodnova T. V. , Sokolenko A. P. , Kotiv Kh. B. , Berlev I. V. , Imyanitov E. N.
Published: November 2024

We analyzed literature data on the peculiarities of the clinical manifestation and therapeutic approaches ofB RCA-associated ovarian carcinomas. The ESMO-ESGO consensus emphasised the importance of determining BRCA1/2 status in ovarian cancer patients for planning the entire treatment strategy. BRCA-associated carcinomas differ significantly from sporadic forms in terms of clinical course, response to systemic therapy, spectrum of drugs which are used for treatment, mechanisms of chemoresistance development, and prognosis. This category of patients needs new therapeutic approaches, including the development of tactics to overcome chemoresistance and modification of the entire combined treatment programme.
The long-term clinical efficacy and safety of lenvatinib plus pembrolizumab in endometrial cancer: data from routine clinical practice in Russia
Authors: Protasova A. E. , Rumyantsev A. A. , Sheremet M. Yu. , Goryainova A. Yu. , Volkonsky M. V. , Kedrova A. G. , Kuzmicheva S. V. , Aymamedova O. N. , Musaeva Kh. S. , Soroka S. M. , Romanchuk O. V. , Orlova V. N. , Graft N. G. , Ibragimova M. R. , Merzlikina Yu. I. , Stepura L. V. , Tatulova L. B. , Abasova A. A. , Akopyan A. A. , Arsenyeva E. V. , Vasilyeva Yu. V. , Belonogov A. V. , Krivolapova L. V. , Bobryshev A. A. , Vovk D. Yu. , Luev I. A. , Abidova N. R. , Zhikhorev R. S. , Zhelezkova T. A. , Grigoryan T. T. , Makarkina T. A. , Ekimov V. A. , Zhizhina A. V. , Karabina E. V. , Kuchevskaya O. A. , Filippova V. M. , Linchenko T. A. , Lisaeva A. A. , Fedorova A. N. , Maystrenko K. S. , Markizova E. V. , Kogay E. V. , Krasnorutskaya E. P. , Popova M. E. , Pchelin Yu. Yu. , Ryanzhina R. A. , Sidorov D. B. , Shakhnovich E. B. , Alekseev S. M. , Zinkevich M. V. , Belogortsev I. O. , Chubenko V. A. , Moiseenko V. M. , Abduloeva N. Kh. , Lebedinets A. A. , Strakh L. V. , Semenov L. K. , Bolieva M. B. , Aydaeva F. Z.
Published: November 2024

Background. Endometrial cancer (EC) treatment outcomes need to be improved. Immunotargeted therapy lead to long-term and delayed effects compared to chemotherapy. Estimation of long-term efficacy and quality of life are crucial when we are talking about efficacy in whole.

Aim. To evaluate the long-term clinical efficacy of lenvatinib plus pembrolizumab therapy in patients with EC.

Materials and methods. The study included 43 patients with stages I-IV EC with mismatch repair-proficient tumors and treatment duration of more than 9 months. We evaluated median progression-free survival, objective response, duration of treatment depending on the line of therapy, prevalence and type of adverse events, and correction regimens. Results. Lenvatinib plus pembrolizumab treatment was safe and efficacious in recurrent EC. Median of progression-free survival (patients with response or stabilization more than 9 months) is 10.2 months (95 % confidence interval 9.1-13.0), median of follow up is 9.7 (1.4-33.8) months. There were no complete responses, partial response was in 12 (28 %) patients, disease stabilization was in 31 (72 %) patients. Regarding safety, the overall rate of any-grade adverse events was 56.3 %. The most common treatment-related adverse events were fatigue (32.6 %), hypertension (23.3 %), and hypothyroidism (18.6 %). Dose reduction was performed in 22 (51.2 %) patients.

Conclusion. The combination of lenvatinib plus pembrolizumab has long-term efficacy and manageable profile of safety. The presence of a significant pool of patients with durable response allows improving the survival rate of such patients in Russia.
LEGAL SEMANTICS OF THE CONCEPT OF "DIGITAL ENVIRONMENT"
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, BEZKLUBYI Igor
Published: November 2024

Background. The article conducts scientific exploration of the legal foundations of the world of the digital environment as a certain system of interconnections of its elements. Methods. Problems of a methodological nature are raised, in particular, issues of legal semantics of the digital environment. The questions of the legal nature of the digital environment and its components are touched upon. Results. The appeal to theoretical problems of the concept of the digital environment is caused by the desire to explore the direction in which modern jurisprudence is developing on the way of regulating modern relations in the IT sphere. The emphasis is on the methodology for defining the concept of the digital environment. Issues of human interaction with elements of the digital environment and legal aspects of regulation of private legal relations related to the circulation of digital things and the provision of digital services are disclosed. Сonclusions. The concept of "environment" is defined in its objective and subjective sense. The formation of the digital environment is proposed to be considered according to the three-level criterion: pre-convention, convention, post-convention. Analyzing the elements of the digital environment, it is indicated that not only digital things, but also certain technological systems are its components. It is proposed to consider the elements of the digital environment in their narrow and broad sense. The article provides the author's definition of the concept of "digital environment".
DECISIONS OF THE EUROPEAN COURT OF HUMAN RIGHTS IN THE CONTEXT OF COMPENSATION FOR DAMAGE CAUSED BY MILITARY AGGRESSION
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, IVANOVA Viktoriia
Published: November 2024

Background. The article addresses the study of the practice of the ECtHR in the context of compensation for damage caused by military aggression, which is important for determining the future strategy of Ukraine in the process of ensuring compensation for the damage caused. Methods. Formal-dogmatic, systematic and comparative-legal methods were used in the research, the basis of the research was the method of systemic analysis. Results. Some decisions of the ECHR based on the statements of victims in the Turkish-Cypriot, russian-Georgian confrontations were analyzed and the effectiveness of such method of protection as an appeal to the ECHR for compensation for damage caused by military aggression was determined. The possibility of Ukraine and other affected individuals and legal entities applying to the ECHR, taking into account the exclusion of the russian Federation from the Council of Europe on September 16, 2022, was assessed. A review and analysis of 40 decisions of the ECtHR related to military aggression was carried out, which is the basis for building the position of the injured party when applying for the protection of violated rights, since after the end of the war the most urgent issue will be the reconstruction of infrastructure, compensation for family members of the dead, wounded, prisoners of war, and other afflicted victims morally or physically together with financing the further development of Ukraine. The methods of influencing the Cabinet of Ministers of the Council of Europe on the respondent country in order to ensure the implementation of ECtHR decisions are analyzed. Possible options for the development of the events after the satisfaction of the complaints of victims of the russian-Ukrainian war are described. Conclusions. A logical summary of the analyzed topic about two possible ways of obtaining fair and real compensation for damage caused by the military aggression of the russian federation was formed and revealed: voluntary and forced.
INFLATION CONVERGENCE IN FRAGILE FIVE COUNTRIES: EVIDENCE FROM RALS-LM UNIT ROOT TESTS
Authors: Göktaş Özlem
Published: November 2024

Bu çalışmanın amacı, Kırılgan Beşli ülkeleri olan Brezilya, Endonezya, Güney Afrika, Hindistan ve Türkiye’de enflasyon yakınsaması olup olmadığının sınamaktır. Çalışmada 1995:1-2023:12 dönemi aylık TÜFE endeksi verileri dikkate alınmıştır. Her bir ülkeye ait enflasyon oranı grup ortalamasından çıkartılarak elde edilen enflasyon fark değişkenlerine yapısal kırılmayı dikkate alan geleneksel LM ve RALS-LM birim kök testleri uygulanmıştır. Geleneksel LM birim kök testlerinde kullanılan regresyonların kalıntılarının normal dağılıma uygunluk göstermediğinin belirlenmesinin ardından RALS-LM birim kök testlerinin sonuçları dikkate alınmıştır. Elde edilen sonuçlar değerlendirildiğinde sadece Hindistan ve Türkiye ülkelerinde enflasyon yakınsamasının olduğu belirlenmiştir. Bu sonuçlara göre Kırılgan Beşli ülkeleri arasında enflasyon yakınsamasının zayıf düzeyde olduğu ifade edilebilmektedir. Kırılgan Beşli ülkeleri arasında zayıf düzeyde enflasyon yakınsamasının varlığı, bu ülkeler açısından ortak bir para politikasının oluşturulamayacağını ve ortak bir parasal bir birliğin kurulamayacağının göstergesidir.
BİLGİ VE İLETİŞİM TEKNOLOJİLERİNİN YOLSUZLUK ÜZERİNDEKİ ETKİSİ: AB GEÇİŞ EKONOMİLERİ ÖRNEĞİ
Authors: KARAMIKLI ÇETİN Aysun , AYTEMİZ Levent
Published: November 2024

Toplumlarda yolsuzluğun yaygınlaşması, toplumlar açısından çok sayıda sosyal ve ekonomik maliyete yol açabilmektedir. Bu bağlamda yolsuzluk kamu kaynaklarının israf edilmesine, halkın hükümete olan güveninin azalmasına, verimsizlik ve adaletsizliğe yol açabilmektedir. Bu çalışmada JKS (2021) nedensellik testi kullanılarak 2002-2022 döneminde 11 AB geçiş ekonomisinde bilgi ve iletişim teknolojileri ile yolsuzluk arasındaki karşılıklı etkileşim incelenmiştir. Nedensellik analizi sonuçları bilgi ve iletişim teknolojileri ile yolsuzluk arasında karşılıklı etkileşim olduğunu göstermektedir.
2942 SAYILI KAMULAŞTIRMA KANUNUNA GÖRE ARAZİ VASFINDAKİ TAŞINMAZLARIN DEĞERİ İLE PİYASA DEĞERİ ARASINDAKİ FARKLILIKLARIN ORTAYA KONULMASI: GÖLBAŞI ÖRNEĞİ
Authors: Tanrıvermiş Yeşim , KILIÇ Bilal
Published: November 2024

Kamu ve özel sektör eli ile yapılan altyapı yatırımları (demiryolu, baraj, karayolu, enerji nakil hatları, doğalgaz ve petrol boru hatları) için arazi edinimi ve taşınmaz değerlerinin belirlenmesi büyük önem taşımaktadır. Türkiye’de kamu ve özel sektör tarafından yapılacak yatırım projeleri için taşınmazların temini kapsamında idarelerin tam ve kısmen kamulaştırma veya irtifak kamulaştırması işlemlerinde başlıca sorun, arazi değerlerinin tespitinde yaşanmaktadır. Yatırım projelerinin inşa edildiği alanda veya güzergahta bulunan taşınmazların değerleme işlemleri 2001 tarih ve 4650 Sayılı Kanun ile değişik 2942 sayılı Kamulaştırma Kanunu’nun ilgili maddelerine göre yapılmaktadır. Kamulaştırmaya konu olan taşınmazın vasfına göre üç farklı değerleme yöntemi kullanılmakta olup arsa vasfında ise emsal değer, arazi vasfında ise gelir değeri ve taşınmaz üzerinde yapı var ise maliyet-birikmiş amortisman üzerinden değer tespiti yapılmaktadır. Söz konusu yatırımların genellikle tarım arazilerinden geçmesi sebebiyle ilgili Kanuna göre taşınmazın değeri net gelir yöntemine göre belirlenmektedir. Ancak yapılan değer tespiti piyasa değerinin altında kalması ve gerçeği yansıtmaması sebebiyle çoğu zaman taşınmazın sahibi tarafından kabul görmemektedir.
Araştırmada amaçlanan; arazi ediniminde kullanılan net gelir yönteminin değer tespiti konusunda eksik yönlerini ortaya çıkarmaktır. Bu kapsamda Ankara İli Gölbaşı İlçesi Halaçlı Mahallesi’nde 34 adet, Tulumtaş Mahallesi’nde 24 adet, Topaklı Mahallesi’nde 12 adet ve Velihimmetli Mahallesi’nde 55 adet olmak üzere toplam 125 adet parsel tarım arazisi incelenmiştir. Taşınmazların kuru tarım arazisi ve sulu tarım arazisi ayrımı yapılarak Net Gelir Yöntemi ile Karşılaştırmalı Satış Analizine göre değer tespitleri yapılmış, değerler arasındaki farklılıklar tespit edilmiştir. Sonuç olarak net gelir yöntemine göre bulunan değerlerin taşınmazların piyasa değerini yansıtmaması ve yasal çerçevede yapılabilecek değişiklikler ile çözüm önerileri üzerinde durulmuştur.
TÜRKİYE’DE FOSİL YAKIT VE YENİLENEBİLİR ENERJİNİN YÜK KAPASİTESİ FAKTÖRÜNE ETKİSİ: SÜRDÜRÜLEBİLİR ÇEVRE İÇİN BOOTSTRAP FARDL YAKLAŞIMI
Authors: Çabaş Meral
Published: November 2024

Bu çalışma fosil yakıt kullanımı, yenilenebilir enerji kullanımı, ekonomik büyüme ve kentleşmenin yük kapasitesi faktörüyle etkileşimlerini Türkiye özelinde ekonometrik olarak incelemeyi amaçlamaktadır. Yük kapasitesi faktörü çevresel arzın yanında çevresel talebi de okuyabilen oldukça kapsamlı bir çevre göstergesidir. 1961-2022 ve 1990-2022 dönemi yıllık verilerin kullanıldığı çalışmada uzun dönem etkileşimler Bootstrap FARDL eşbütünleşme testiyle sınanmış bu etkileşimlere ait katsayılar FMOLS (Tamamen Değiştirilmiş En Küçük Kareler) ve DOLS (Dinamik Sıradan En Küçük Kareler) tahmincileriyle elde edilmiştir. Elde edilen sonuçlara göre Türkiye’de fosil yakıt kullanımı, yenilenebilir enerji kullanımı, ekonomik büyüme ve kentleşmenin yük kapasitesi faktörüyle uzun dönem etkileşimlerini doğrulamaktadır. Fosil yakıt kullanımı, ekonomik büyüme ve kentleşme yük kapasitesi faktörünü azaltarak çevresel sürdürülebilirliğe zarar verirken yenilenebilir enerji kullanımı yük kapasitesi faktörünü artırmaktadır. Bu durum bize Türkiye’de yenilenebilir enerji kaynaklarının artırılmasının ve kullanımının yaygın hale getirilmesinin gerekliliğini göstermektedir. Kentleşmenin ve ekonomik büyümenin çevresel tahribata neden olduğu göz önünde bulundurulduğunda çevre dostu yeşil teknolojiler ve yeşil finansmanın kentsel gelişim ve ekonomik büyümeye entegrasyonu yük kapasitesi faktörünü artırarak sürdürülebilir çevreyi destekleyebilecektir.
KANSER TEDAVİSİNDE HASTA MEMNUNİYETİ VE TRAKYA ÜNİVERSİTESİ BALKAN ONKOLOJİ HASTANESİ ÖRNEĞİ
Authors: ÇİÇİN Fatma Nur , Çiftçi Murat
Published: November 2024

Amaç: Bu çalışmada da kanserle mücadelede bir ihtisas hastanesi olan Trakya Üniversitesi Balkan Onkoloji Hastanesi’nde sunulan sağlık hizmetlerinden yatan ve ayakta tedavi gören hastaların memnuniyet düzeyleri test edilmiştir.
Veri Edinimi: Anket çalışması Nisan – Eylül 2017 tarih aralığında Trakya Üniversitesi Balkan Onkoloji Hastanesi’nde yatan ve ayakta tedavi gören hasta gruplarının her ikisini de kapsamıştır. Anketler yatarak tedavi gören hastaları temsilen 226 kişiye ve ayaktan tedavi gören hastaları temsilen de 439 kişiye olmak üzere toplam 665 deneğe uygulanmıştır.
Yöntem: Anket çalışması gerçekleştirildikten sonra veri analizinde ilk olarak betimleyici temel istatistiklerin tablolaması gerçekleştirilmiştir. Betimleyici istatistikler sonrasında güvenilirlik testi gerçekleştirilmiştir. Ardından da ölçek geçerliliği test edilmiştir. Güvenilirliğin ve geçerliliğin ön koşul olarak tespiti sonrasında bu defa ikili ve çoklu fark testleri yapılmıştır.
Bulgular: Çalışmada elde edile bulgular hem yatarak hem de ayakta tedavi edilen hastaların verilen hizmetten genel olarak yüksek memnuniyete sahip olduklarını desteklemektedir. Deneklerin memnuniyet düzeylerindeyse cinsiyete, medeni duruma ve gelir durumuna göre istatistiksel olarak anlamlı bir ayrışmanın görülmediği tespit edilmiştir. Buna karşılık sunulan bazı sağlık hizmetlerinde deneklerin mezuniyet düzeyine göre istatistiksel olarak anlamlı farkın varlığı tespit edilmiştir.
Sonuç: çalışmada elde edilen bulgular, hem ve yatan hem de ayakta tedavi gören hastaların, Trakya Üniversitesi Balkan Onkoloji Hastanesi’nde sunulan otelcilik hizmetlerinden hem de sağlık personelince sunulan tedavi edici sağlık hizmetinden yüksek düzeyde memnun olduklarını desteklemektedir.
GELİŞMEKTE OLAN ÜLKELERDE BANKA KRİZLERİ İLE MAKRO İHTİYATİ POLİTİKALARIN DİNAMİK ETKİLEŞİMLERİ
Authors: Tunay K. Batu , TUNAY Necla
Published: November 2024

Bu çalışmada, seçilmiş gelişmekte olan ekonomiler örneği üzerinden makro ihtiyati politikaların banka krizi olasılığını düşürüp düşürmediği ekonometrik olarak analiz edilmiştir. Analizlerde, orta üst gelir grubunda yer alan ve geçmiş kırk yıllık dönemde iki veya daha fazla banka krizi deneyimi olan yedi gelişmekte olan ülkeden derlenen veriler kullanılmıştır. Çalışma banka krizleri ile makro ihtiyati politikalar arasındaki dinamik etkileşimleri merkezine almasına karşın, büyüme hızı ve enflasyon oranları gibi bazı kilit makro ekonomik değişkenler ile banka krizlerinin öncü göstergelerinden birisi olarak kabul edilen kredi açığı da analizlere dahil edilmiştir. Tüm bu değişkenler, modellemede bağımlı değişkenler olarak dikkate alınmıştır. Diğer yandan, gelişmekte olan ekonomilerde finansal sarsıntılara ve krizlere neden olabilen dış şokların etkilerini temsilen petrol fiyatları ve ABD merkez bankasının politika oranı bağımsız değişkenler olarak modellerde yer almıştır. Bu değişkenler seti, panel yapısal kalitatif vektör otoregresyon yöntemi ile analiz edilmiş ve olası şokların etkilerini saptayabilmek için etki-tepki fonksiyonları hesaplanmıştır. Ulaşılan bulgular, makro ihtiyati politikaların banka krizi olasılığını düşürdüğünü göstermiştir. Bununla beraber, bu tür politikaların ekonomik faaliyette yavaşlamaya neden olduğu da görülmüştür. Yüksek büyüme potansiyeli olan gelişmekte olan ülkeler için bu yavaşlamanın kısa süreli olacağı söylenebilir. Diğer yandan, ekonomide toplam arz veya toplam talep şokları meydana gelmesi durumunda banka sisteminin krize girme olasılığının arttığı da saptanmıştır.