bluuebunny/crossref_metadata_2025 huggingface dataset:
Using Continuous Passive Assessment Technology to Describe Health and Behavior Patterns Preceding and Following a Cancer Diagnosis in Older Adults: Proof-of-Concept Case Series Study
Authors: Wu Chao-Yi , Tibbitts Deanne , Beattie Zachary , Dodge Hiroko , Shannon Jackilen , Kaye Jeffrey , Winters-Stone Kerri
Published: May 2023

Background

Describing changes in health and behavior that precede and follow a sentinel health event, such as a cancer diagnosis, is challenging because of the lack of longitudinal, objective measurements that are collected frequently enough to capture varying trajectories of change leading up to and following the event. A continuous passive assessment system that continuously monitors older adults’ physical activity, weight, medication-taking behavior, pain, health events, and mood could enable the identification of more specific health and behavior patterns leading up to a cancer diagnosis and whether and how patterns change thereafter.

Objective

In this study, we conducted a proof-of-concept retrospective analysis, in which we identified new cancer diagnoses in older adults and compared trajectories of change in health and behaviors before and after cancer diagnosis.

Methods

Participants were 10 older adults (mean age 71.8, SD 4.9 years; 3/10, 30% female) with various self-reported cancer types from a larger prospective cohort study of older adults. A technology-agnostic assessment platform using multiple devices provided continuous data on daily physical activity via wearable sensors (actigraphy); weight via a Wi-Fi–enabled digital scale; daily medication-taking behavior using electronic Bluetooth-enabled pillboxes; and weekly pain, health events, and mood with online, self-report surveys.

Results

Longitudinal linear mixed-effects models revealed significant differences in the pre- and postcancer trajectories of step counts (P<.001), step count variability (P=.004), weight (P<.001), pain severity (P<.001), hospitalization or emergency room visits (P=.03), days away from home overnight (P=.01), and the number of pillbox door openings (P<.001). Over the year preceding a cancer diagnosis, there were gradual reductions in step counts and weight and gradual increases in pain severity, step count variability, hospitalization or emergency room visits, and days away from home overnight compared with 1 year after the cancer diagnosis. Across the year after the cancer diagnosis, there was a gradual increase in the number of pillbox door openings compared with 1 year before the cancer diagnosis. There was no significant trajectory change from the pre– to post–cancer diagnosis period in terms of low mood (P=.60) and loneliness (P=.22).

Conclusions

A home-based, technology-agnostic, and multidomain assessment platform could provide a unique approach to monitoring different types of behavior and health markers in parallel before and after a life-changing health event. Continuous passive monitoring that is ecologically valid, less prone to bias, and limits participant burden could greatly enhance research that aims to improve early detection efforts, clinical care, and outcomes for people with cancer.
Investigating the Role of Nutrition in Enhancing Immunity During the COVID-19 Pandemic: Twitter Text-Mining Analysis
Authors: Shankar Kavitha , Chandrasekaran Ranganathan , Jeripity Venkata Pruthvinath , Miketinas Derek
Published: May 2023

Background

The COVID-19 pandemic has brought to the spotlight the critical role played by a balanced and healthy diet in bolstering the human immune system. There is burgeoning interest in nutrition-related information on social media platforms like Twitter. There is a critical need to assess and understand public opinion, attitudes, and sentiments toward nutrition-related information shared on Twitter.

Objective

This study uses text mining to analyze nutrition-related messages on Twitter to identify and analyze how the general public perceives various food groups and diets for improving immunity to the SARS-CoV-2 virus.

Methods

We gathered 71,178 nutrition-related tweets that were posted between January 01, 2020, and September 30, 2020. The Correlated Explanation text mining algorithm was used to identify frequently discussed topics that users mentioned as contributing to immunity building against SARS-CoV-2. We assessed the relative importance of these topics and performed a sentiment analysis. We also qualitatively examined the tweets to gain a closer understanding of nutrition-related topics and food groups.

Results

Text-mining yielded 10 topics that users discussed frequently on Twitter, viz proteins, whole grains, fruits, vegetables, dairy-related, spices and herbs, fluids, supplements, avoidable foods, and specialty diets. Supplements were the most frequently discussed topic (23,913/71,178, 33.6%) with a higher proportion (20,935/23,913, 87.75%) exhibiting a positive sentiment with a score of 0.41. Consuming fluids (17,685/71,178, 24.85%) and fruits (14,807/71,178, 20.80%) were the second and third most frequent topics with favorable, positive sentiments. Spices and herbs (8719/71,178, 12.25%) and avoidable foods (8619/71,178, 12.11%) were also frequently discussed. Negative sentiments were observed for a higher proportion of avoidable foods (7627/8619, 84.31%) with a sentiment score of –0.39.

Conclusions

This study identified 10 important food groups and associated sentiments that users discussed as a means to improve immunity. Our findings can help dieticians and nutritionists to frame appropriate interventions and diet programs.
A Web-Based Dyadic Intervention to Manage Psychoneurological Symptoms for Patients With Colorectal Cancer and Their Caregivers: Protocol for a Mixed Methods Study (Preprint)
Authors: Lin Yufen , Porter Laura S , Chee Wonshik , Alese Olatunji B , Curseen Kimberly A , Higgins Melinda K , Northouse Laurel , Xiao Canhua
Published: May 2023

BACKGROUND

Patients with colorectal cancer (CRC) receiving chemotherapy often experience psychoneurological symptoms (PNS; ie, fatigue, depression, anxiety, sleep disturbance, pain, and cognitive dysfunction) that negatively impact both patients’ and their caregivers’ health outcomes. Limited information is available on PNS management for CRC patient and caregiver dyads.

OBJECTIVE

The purposes of this study are to (1) develop a web-based dyadic intervention for patients with CRC receiving chemotherapy and their caregivers (CRCweb) and (2) evaluate the feasibility, acceptability, and preliminary effects of CRCweb among patient-caregiver dyads in a cancer clinic.

METHODS

A mixed methods approach will be used. Semistructured interviews among 8 dyads will be conducted to develop CRCweb. A single-group pre- and posttest clinical trial will be used to examine the feasibility, acceptability, and preliminary effects of the intervention (CRCweb) among 20 dyads. Study assessments will be conducted before (T1) and after intervention (T2). Content analysis will be performed for semistructured interviews. Descriptive statistics will be calculated separately for patients and caregivers, and pre-post paired t tests will be used to evaluate treatment effects.

RESULTS

This study was funded in November 2022. As of April 2023, we have obtained institutional review board approval and completed clinical trial registration and are currently recruiting patient-caregiver dyads in a cancer clinic. The study is expected to be completed in October 2024.

CONCLUSIONS

Developing a web-based dyadic intervention holds great promise to reduce the PNS burden in patients with CRC receiving chemotherapy and their caregivers. The findings from this study will advance intervention development and implementation of symptom management and palliative care for patients with cancer and their caregivers.

CLINICALTRIAL

ClinicalTrials.gov NCT05663203; https://clinicaltrials.gov/ct2/show/NCT05663203

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/48499
User Perception of Smart Home Surveillance Among Adults Aged 50 Years and Older: Scoping Review (Preprint)
Authors: Percy Campbell Jessica , Buchan Jacob , Chu Charlene H , Bianchi Andria , Hoey Jesse , Khan Shehroz S
Published: May 2023

BACKGROUND

Smart home technology (SHT) can be useful for aging in place or health-related purposes. However, surveillance studies have highlighted ethical issues with SHTs, including user privacy, security, and autonomy.

OBJECTIVE

As digital technology is most often designed for younger adults, this review summarizes perceptions of SHTs among users aged 50 years and older to explore their understanding of privacy, the purpose of data collection, risks and benefits, and safety.

METHODS

Through an integrative review, we explored community-dwelling adults’ (aged 50 years and older) perceptions of SHTs based on research questions under 4 nonmutually exclusive themes: privacy, the purpose of data collection, risk and benefits, and safety. We searched 1860 titles and abstracts from Ovid MEDLINE, Ovid Embase, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials, Scopus, Web of Science Core Collection, and IEEE Xplore or IET Electronic Library, resulting in 15 included studies.

RESULTS

The 15 studies explored user perception of smart speakers, motion sensors, or home monitoring systems. A total of 13 (87%) studies discussed user privacy concerns regarding data collection and access. A total of 4 (27%) studies explored user knowledge of data collection purposes, 7 (47%) studies featured risk-related concerns such as data breaches and third-party misuse alongside benefits such as convenience, and 9 (60%) studies reported user enthusiasm about the potential for home safety.

CONCLUSIONS

Due to the growing size of aging populations and advances in technological capabilities, regulators and designers should focus on user concerns by supporting higher levels of agency regarding data collection, use, and disclosure and by bolstering organizational accountability. This way, relevant privacy regulation and SHT design can better support user safety while diminishing potential risks to privacy, security, autonomy, or discriminatory outcomes.
Evaluation of Incremental Validity of Casper in Predicting Program and National Licensure Performance of Undergraduate Nursing Students: Protocol for a Mixed Methods Study (Preprint)
Authors: Stevens Kathleen , Moralejo Donna , Crossman Renee
Published: May 2023

BACKGROUND

Academic success has been the primary criterion for admission to many nursing programs. However, academic success as an admission criterion may have limited predictive value for success in noncognitive skills. Adding situational judgment tests, such as Casper, to admissions procedures may be one strategy to strengthen decisions and address the limited predictive value of academic admission criteria. In 2021, admissions processes were modified to include Casper based on concerns identified with noncognitive skills.

OBJECTIVE

This study aims to (1) assess the incremental validity of Casper scores in predicting nursing student performance at years 1, 2, 3, and 4 and on the National Council Licensing Examination (NCLEX) performance; and (2) examine faculty members’ perceptions of student performance and influences related to communication, professionalism, empathy, and problem-solving.

METHODS

We will use a multistage evaluation mixed methods design with 5 phases. At the end of each year, students will complete questionnaires related to empathy and professionalism and have their performance assessed for communication and problem-solving in psychomotor laboratory sessions. The final phase will assess graduate performance on the NCLEX. Each phase also includes qualitative data collection (ie, focus groups with faculty members). The goal of the focus groups is to help explain the quantitative findings (explanatory phase) as well as inform data collection (eg, focus group questions) in the subsequent phase (exploratory sequence). All students enrolled in the first year of the nursing program in 2021 were asked to participate (n=290). Faculty will be asked to participate in the focus groups at the end of each year of the program. Hierarchical multiple regression will be conducted for each outcome of interest (eg, communication, professionalism, empathy, and problem-solving) to determine the extent to which scores on Casper with admission grades, compared to admission grades alone, predict nursing student performance at years 1-4 of the program and success on the national exam. Thematic analysis of focus group transcripts will be conducted using interpretive description. The quantitative and qualitative data will be integrated after each phase is complete and at the end of the study.

RESULTS

This study was funded in September 2021, and data collection began in March 2022. Year 1 data collection and analysis are complete. Year 2 data collection is complete, and data analysis is in progress.

CONCLUSIONS

At the end of the study, we will provide the results of a comprehensive analysis to determine the extent to which the addition of scores on Casper compared to admission grades alone predicts nursing student performance at years 1-4 of the program and on the NCLEX exam.

INTERNATIONAL REGISTERED REPORT

RR1-10.2196/48672
Migración internacional calificada por razones de estudio: Colombianas en México
Authors: Bedoya Rangel Yuliet
Published: May 2023

La mujer siempre ha estado presente en los movimientos migratorios históricos de la humanidad y, aunque por mucho tiempo las migraciones femeninas se han invisibilizado o neutralizado en discursos migratorios androcéntricos, estudios recientes han enfocado su análisis en la importancia que tienen las mujeres en los ámbitos social, cultural y económico de las sociedades de origen y destino, en contextos migratorios nacionales e internacionales. Este es el caso del libro Migración internacional calificada por razones de estudio: Colombianas en México, publicado en 2019, que presenta una aportación muy importante al estudio de las migraciones; específicamente, a la movilidad internacional de mujeres calificadas y a la movilidad de las mujeres entre países latinoamericanos.
Unidades de producción agrícola y rentabilidad: Tecajec, Yecapixtla, Morelos / Units of agricultural production and profitability: Tecajec, Yecapixtla, Morelos
Authors: Mercado Yebra Joaquín , Yañez Carrillo Lucero
Published: May 2023

El objetivo de este artículo es dimensionar y analizar la rentabilidad de la producción agrícola familiar de temporal en tres unidades económicas, con el fin de determinar en qué medida el excedente económico, efectivo e imputado, cubre los requerimientos de consumo y reproducción del capital del ciclo agrícola. El trabajo de campo se realizó en la localidad de Tecajec, Yecapixtla, Morelos, en el periodo de junio de 2016 a mayo de 2017 y se utilizó el método de investigación en granjas complementado con técnicas de estudios de caso. El resultado fue que el excedente resultó insuficiente para cubrir los costos efectivos e imputados de la mano de obra y el beneficio promedio por actividades de organización, es decir, no existe equilibrio entre el trabajo familiar con las necesidades de consumo y de reposición del capital; los subsidios fueron indispensables para el nuevo ciclo de producción.Abstract: The objective of the article is to measure and analyze the profitability of seasonal family agricultural production in three economic units, in order to determine to what extent the economic surplus, effective and imputed, covers the consumption and reproduction requirements of the capital of the agricultural cycle. The fieldwork was carried out in the town of Tecajec, Yecapixtla, Morelos, in the period June 2016- May 2017, using the farm research method complemented with case study techniques. It was found that the surplus was insufficient to cover the effective and imputed costs of labor and the average benefit from organizational activities, that is, there is no balance between family work and the needs of consumption and replacement of capital; the subsidies were indispensable for the new production cycle.Keywords: agricultural unit; profitability; surplus; subsidies; peasant family.Résumé : L’objectif de l’article est de mesurer et d’analyser la rentabilité de la production agricole familiale saisonnière dans trois unités économiques, afin de déterminer dans quelle mesure le surplus économique, effectif et imputé, couvre les besoins de consom­mation et de reproduction du capital du cycle agricole. Le travail de terrain a été réalisé dans la ville de Tecajec, Yecapixtla, Morelos, entre juin 2016 et mai 2017, en utilisant la méthode de recherche agricole complétée par des techniques d’étude de cas. Il a été constaté que l’excédent était insuffisant pour couvrir les coûts effectifs et imputés du travail et le bénéfice moyen des activités organisationnelles, c’est-à-dire qu’il n’y a pas d’équilibre entre le travail familial et les besoins de consommation et de remplacement du capital; les subventions étaient indispensables pour le nouveau cycle de production.Mots clés : unité agricole ; rentabilité ; surplus ; subventions ; famille paysanne.
La imitación entre los mexicas / Imitation among the Mexica
Authors: Dehouve Danièle
Published: May 2023

Las ciencias sociales abordan la imitación desde un doble punto de vista: como gesto y como disfraz de la personalidad (mimicry). Una distinción similar se encuentra en el vocabulario de la imitación en la lengua náhuatl (la lengua de los mexicas del centro de México en el siglo XVI): imitar mediante gestos repetidos y concomitantes (expresados por verbos reduplicativos) y asumir una personalidad distinta de la propia («complejo ixiptla»).Abstract: The social sciences approach imitation from a double point of view: as gesture and as disguise of the personality (mimicry). A comparable distinction can be found in the vocabulary of imitation in the Nahuatl language (the language of the Aztecs of central Mexico in the 16th century): imitating by means of repeated and concomitant gestures (expressed by reduplicative verbs) and taking on a personality other than one’s own («ixiptla complex»).Keywords: Nahuatl; imitation; mimicry; gestures; ixiptla.Resumé : Les sciences sociales abordent l’imitation d’un double point de vue : comme gestuelle et comme déguisement de la personnalité (mimicry). On trouve une distinction comparable dans le vocabulaire de l’imitation en langue nahuatl (langue des Aztèques du Mexique central au XVIe siècle) : imiter au moyen de gestes répétés et concomitants (exprimé par des verbes à réduplication) et endosser une personnalité autre que la sienne (« complexe ixiptla »).Mots-clés : Nahuatl ; imitation ; mimicry ; gestuelle ; ixiptla.
El cuerpo y lo virtual: Danzas y combates en Mesoamérica / Le corps et le virtuel : danses et combats en Mésoamérique
Authors: Dehouve Danièle
Published: May 2023

En Hispanoamérica, las representaciones festivas son manifestaciones colectivas que se distinguen de la vida cotidiana y se pueden analizar con la ayuda de varias categorías, entre ellas, las danzas, las luchas, los espectáculos, los ritos y los juegos. En la actualidad, en el México indígena y rural, se utiliza comúnmente el término genérico de danza, que se refiere a una variedad de prácticas de origen diverso, derivadas tanto de los rituales teatrales prehispánicos como del teatro evangelizador colonial. La danza es una representación con motivo de una fiesta patronal con más o menos espectadores; combina música, danza o diálogos recitados. Hay todo tipo de danzas, pero lo que tienen en común es que se conciben como físicamente duras y se viven como un sacrificio personal. Así, algunas peleas se llaman bailes y algunos de estos incluyen enfrentamientos violentos.Les représentations festives de l’Amérique espagnole sont des manifestations collectives qui se distinguent de la vie quotidienne et relèvent de plusieurs catégories d’analyse en sciences humaines –entre autres, les danses, les combats, les spectacles, les rites et les jeux. De nos jours, le Mexique indien et rural utilise couramment le terme générique espagnol danza (danse) qui se réfère à des pratiques hétéroclites, et d’origine diverse, puisqu’elles dérivent tout à la fois des rituels théâtralisés précolombiens et du théâtre d’évangélisation colonial. La danza est une représentation exécutée à l’occasion d’une fête patronale avec plus ou moins de spectateurs ; elle conjugue musique, danse et/ou dialogues récités. Il en existe de toutes sortes mais leur point commun est qu’elles sont conçues comme physiquement dures et vécues comme un sacrifice personnel. En ce sens, certains combats reçoivent l’appellation de danses, tandis que certaines danses incluent des confrontations violentes.
A propósito de "Combinar para convivir": Aportes y replanteamientos
Authors: Mora Martínez Libertad
Published: May 2023

Después de algún tiempo, volvemos a tener otra obra de la etnóloga francesa Anath Ariel de Vidas, quien, como suele hacerlo, con un adecuado ojo etnográfico e interesante reflexión e interpretación del dato empírico, da como resultado Combinar para convivir: Etnografía de un pueblo nahua de la Huasteca veracruzana en tiempos de modernización.
Системна хiмiотерапiя при нерезектабельнiй формi внутрiшньопечiнкової саркоматоїдної холангiокарциноми: клiнiчний випадок та огляд лiтератури
Authors: Hrуnenko O.V. , Zaivelieva Iu.I. , Kropelnytskyi V.O. , Ostapyshen O.M. , Fedorov D.O.
Published: May 2023

Рак бiлiарного тракту (РБТ) є гетерогенною групою злоякiсних новоутворень, якi походять з епiтелiю жовчних проток i можуть локалiзуватися в рiзних вiддiлах жовчовивiдних шляхiв. Саркоматоїдна внутрiшньопечiнкова холангiокарцинома (сВХК) є надзвичайно рідкісним пiдтипом РБТ, що складається зi злоякiсних клiтин, які поєднують епiтелiальнi та мезенхiмальнi властивостi. На сьогоднi основною терапевтичною опцiєю сВХК є хiрургiчне лiкування. У цiй публiкацiї ми презентуємо результати обстеження та лiкування пацiєнтки з нерезектабельною формою сВХК та огляд сучасної лiтератури щодо наявних пiдходiв до лiкування цього захворювання.
A Study on the Efficiency of Disaster Information Communication Based on the Gate Keeper Theory
Authors: Shaojie Cai , Wanru Wang
Published: May 2023

In recent years, major disasters have occurred frequently, with sudden floods, rampant epidemics, and typhoons... Faced with sudden disasters, the affected population is often caught unprepared. Under the background of “Internet +”, the speed of information circulation has improved, but the news that the material needs of the disaster victims are not effectively met still often appears in the public’s view. In order to improve the efficiency of disaster information dissemination and enable the efficient distribution of related materials, this paper discusses this issue based on the gatekeeper theory of communication science. With a view to tracing the source and clarifying the reasons for the low efficiency and poor effect of disaster mutual aid information dissemination under the background of “Internet +”, this paper proposes solutions to the problems in combination with the gatekeeper theory of communication, to promote the rational distribution and utilization of resources, meet the material needs of disaster victims, and ensure the basic life of the people.
FORMULATION OF NANOEMULGEL CONTAINING EXTRACT OF IMPATIENTS BALSAMINA L. AND ITS ANTIBACTERIAL ACTIVITY
Authors: WIKANTYASNING ERINDYAH RETNO , SETIYADI GUNAWAN , PRAMUNINGTYAS RATIH , KURNIAWATI MEGA DWI , YEE HO CHAI
Published: May 2023

Objective: This study aimed to optimize the nanoemulgel formulation for balsam leaves (Impatients balsamina L.) extract and determine its antibacterial activity.
Methods: Balsam leaves were extracted using the maceration method using ethanol. The nanoemulsion of balsam leaves ethanol extract was prepared with various oil, surfactants, and co-surfactant concentrations. Characterization was conducted on the nanoemulsion formed, including transmittance, droplet size, polydispersity index, and zeta potential. The chosen nanoemulsion formula was then transformed into a gel preparation using various gelling agent concentrations, i.e., Carbopol 940 and chitosan, and optimized using the Design-Expert v13 software with the simplex lattice design method.
Results: The study discovered the optimum nanoemulgel formula with a desirability value of 0.859. The ratio of Carbopol 940 with chitosan was 1.38% and 0.12%w/w, respectively, with an antibacterial activity inhibition zone against S. epidermidis of 22±2 mm in diameter.
Conclusion: The observed responses closely matched the predicted values provided by the optimization method. The optimized nanoemulgel formulation has the potential to develop as an antibacterial dosage form.
FORMULATION AND DEVELOPMENT OF GALLEN GUM LOADED SELF-ASSEMBLED MIXED MICELLES SYSTEM BASED ON FLAVONOID PHOSPHOLIPID COMPLEX
Authors: BHANGE MANJUSHA A. , PETHE ANIL M. , JADHAV AMRAPALI , KANADJE HARSHADA
Published: May 2023

Objective: Research on the development of pharmaceutical self-assembled mixed micells systems is in that they have the advantage of keeping the drug's encapsulating qualities while also enhancing its physicochemical characteristics. The goal of this study was to make the class II biopharmaceutical quercetin more soluble in water and more bioavailable when taken orally (QCT). The enhancement of encapsulation and flavonoids loading within mixed micelles using solvent evapouration technique.
Methods: In the present study, pharmaceutical mixed micells of a BCS class II drug, QCT were prepared using solvent evapouration technique method. Prepared mixed micells were characterized using Critical micelle concentration (CMC), Fourier Transform Infrared (FT-IR), Particle size and zeta potential, Powder X-Ray Diffract meter (PXRD), In vitro dissolution, Transmission electron microscopy (TEM). In addition In vitro drug release studies were also performed.
Results: The results of the characterization studies indicated the designing of gallen gum loaded self-assembled mixed micelles system based on flavonoid phospholipid complex. The CMC of LS-75 and LS-100 binary mixture had shows good results to be 0.0013%. The FTIR spectra of complex showed characteristic peak of QCT shows abundant effect on O-H (aromatic), C-O (aromatic), C-C, and aromatic C-O is observed at 3282.2, 1620.1, 1058.7, and 1162.2 respectively. The average particle size of design-optimized quercetin mixed micells (QCT-MMs) was demonstrated to be ~116.1 nm, as evaluated by Malvern. From the obtained particle size, it indicated that the particle size of QCT in QCT-MMs was widely distributed. The polydispersity index (PDI) for QCT-MMs was found in the range of ~ 1.000, zeta potential value for QCT-MMs as evaluated by Malvern was observed to be ~-99.2 mV. The P-XRD, SEM, showed good powder diffraction results with having good flow property. Also formulation were evaluated for the In vitro drug dissolution study for rate of extent of drug release and dissolution rate release of QCT from QCT-MMs was sustained up to 72 h. TEM images of QCT-MMs, where the micelles exhibited relatively regular dark stained shapes appearing more or less spherical or spheroid.
Conclusion: It can be concluded that the QCT-MMs enhance the aqueous solubility of the QCT and increased the bioavailability and retention time.
DEVELOPMENT AND CHARACTERIZATION OF PH-RESPONSIVE POLYMERIC MICROBEADS INTERCALATED WITH MONTMORILLONITE FOR CONTROLLED RELEASE OF DOXORUBICIN
Authors: RATHNAM S. RANGA , REDDY O. SREEKANTH , PATWARI S. B.
Published: May 2023

Objective: The aim of the present study is to develop pH-responsive polymeric microbeads for controlled release of doxorubicin. Methods: Doxorubicin-encapsulated polymeric microbeads were developed by a simple ionotropic gelation method using sodium alginate, gum ghatti, and montmorillonite (MMT). In this work, we investigate the positive benefits of MMT mineral as a drug carrier for the controlled release of DOX. X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) were used to characterize the generated microbeads. The influence of hetero-ionic concentration on drug encapsulation efficiency and drug release from microbeads was examined. In vitro release and swelling studies were performed at pH 2.0 and 7.4 at 37 °C. The cytotoxicity of the developed microbeads was studied using in vitro cultures of the human breast cancer cell line (MCF-7). Results: FTIR confirms the generation of microbeads and also the interaction between the polymer matrix, DOX and MMT clay. XRD analysis reveals the molecular dispersion of DOX and the presence of MMT in the polymeric matrix. SEM studies reveal the developed microbeads are spherical in shape with rough surfaces. Swelling and in vitro release studies are dependent on the pH of the test medium, which may be favorable for intestinal drug delivery. MTT results reveal that the developed microbeads showed good in vitro toxicity against MCF-7 cells. The drug release kinetics of the generated microbeads are followed by both the higuchi and korsmeyer-peppas models. Conclusion: The findings suggest that the DOX-encapsulated microbeads are promising carriers for drug delivery applications. The fabricated microbeads further needs warrant for drug delivery applications.
NANOSPONGES: AS A DYNAMIC DRUG DELIVERY APPROACH FOR TARGETED DELIVERY
Authors: SHARMA PANKAJ , SHARMA ABHISHEK , GUPTA AVNEET
Published: May 2023

Recent advancements in nanotechnology have resulted in improved medicine delivery to the target site. Nanosponges are three-dimensional drug delivery systems that are nanoscale in size and created by cross-linking polymers. The introduction of Nanosponges has been a significant step toward overcoming issues such as drug toxicity, low bioavailability, and predictable medication release. Using a new way of nanotechnology, nanosponges, which are porous with small sponges (below one µm) flowing throughout the body, have demonstrated excellent results in delivering drugs. As a result, they reach the target place, attach to the skin's surface, and slowly release the medicine. Nanosponges can be used to encapsulate a wide range of medicines, including both hydrophilic and lipophilic pharmaceuticals. The medication delivery method using nanosponges is one of the most promising fields in pharmacy. It can be used as a biocatalyst carrier for vaccines, antibodies, enzymes, and proteins to be released. The existing study enlightens on the preparation method, evaluation, and prospective application in a medication delivery system and also focuses on patents filed in the field of nanosponges.
OPTIMIZATION, CHARACTERIZATION AND IN VIVO STUDY OF RIVASTIGMINE TARTRATE NANOPARTICLES BY USING 22 FULL FACTORIAL DESIGN FOR ORAL DELIVERY
Authors: DUBEY NEHA , AGRAWAL OM PRAKASH , GIDWANI BINA
Published: May 2023

Objective: This research aims to optimize the solid lipid nanoparticles by using full factorial design to improve the delivery of rivastigmine tartrate (RT), which is used for the treatment of Alzheimer’s disease (AD). Solid lipid nanoparticles (SLNs) are attracting importance for drug developers due to their performance. The outcome of this research will lead to improvements in drug release and solubility of RT for better therapeutic effect.
Methods: Four different methods were used to prepare solid lipid nanoparticles of rivastigmine tartrate, namely the modified solvent emulsification technique, the microemulsion cooling technique, the solvent injection technique, and the homogenization/ultrasonication technique. Glyceryl monostearate (GMS) was used as a lipid; Compritol 888, tween 80, and span 40 were used as surfactants, co-surfactants, and stabilizers, respectively.
Results: SLNs were evaluated for zeta potential, particle size, polydispersity index, surface morphology, Fourier Transform Infrared Spectroscopy (FTIR), and differential scanning calorimetry (DSC). Entrapment efficiency and drug loading were also estimated. Solubility study of rivastigmine tartrate in different solid lipids as well as the in vitro drug release, was studied. The particle size of SLNs was found to range between 138.22+0.01 nm and 172.79+0.23 nm. The zeta potential of the optimized formulation was found to be in the the-24+0.01mV range, indicating a stable formulation. A scanning electron microscope indicates a clear spherical structure without any aggregation. Entrapment efficiency was determined to be 69.27+0.22%. The RT-SLNs showed significant retention in memory when compared with RT solution (standard formulation), which may be attributed to the lipid nature and nanostructure of the delivery system that may probably result in more accumulation of the drug in the brain to show better effect.
Conclusion: The current study concludes that the microemulsion cooling technique is the best method for patient compliance and stability with all desired characteristics parameters.
A REVIEW ON THE SOLID ORAL DOSAGE FORM FOR PEDIATRICS, REGULATORY ASPECTS, CHALLENGES INVOLVED DURING THE FORMULATION, AND TOXICITY OF THE EXCIPIENTS USED IN PEDIATRIC FORMULATION
Authors: SANKESHWARI SUSHMITA , H. V. GANGADHARAPPA , K. M. ASHA SPANDANA , ELIYAS ANU , THIRUMALESHWAR SHAILESH , HARSHA VARDHAN PYDA VENKATA
Published: May 2023

Designing an appropriate dosage form in medical treatment for the pediatric population is very challenging. The major challenges faced during designing the oral solid dosage form for pediatrics are also the prerequisites for the development of the dosage form, and they are, administering the drug according to the body weight and taste masking, which is followed by other factors like the safety of excipients, size of dosage form and so on. Oral solid dosage forms like mini-tablets, soluble films, and orally disintegrating tablets are a few promising dosage forms for use in the pediatric population. The obstacles, such as physiological differences between the various age groups, excipient safety, technology requirements, low profitability, clinical trial limitations, and regulatory ambiguity all have an impact on pediatric dosage form development. Recent advancement in the development of pediatrics formulations has been made due to new regulations, more financial opportunities, and novel collaborative research programs. A shift of pattern towards solid oral dosage form and an emphasis on innovative preparations, such as dispersible, flexible, as well as multi-particulate oral solid dose forms, are some of the advanceme nts. Such advancements have allowed for more flexibility of dose, easy administration, and improved medication formulation acceptance in pediatrics. In consideration of dosage forms for pediatrics, issues such as pediatric suitability, excipient selection, prospects for modified drug release formulations or fixed-dose combinations, palatability, and acceptability, as well as challenges were reviewed in the current manuscript.
A SENSITIVE AND ECONOMICAL DIFFERENT SPECTROSCOPIC METHODS DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF CAPECITABINE AND STRESS DEGRADATION STUDIES
Authors: SAI KALLAM JEEVAN , MONDAL SUMANTA , CHAKRABORTY SUBHADIP , REVU BABY NALANDA
Published: May 2023

Objective: The present investigation aims to develop an efficient, rapid, sensitive, selective, linear, and accurate method for analyzing capecitabine in bulk and tablet dosage form by UV-spectroscopy approaches.
Methods: Capecitabine is an estimation by three different developed methods with different UV detection, method A (zero-order spectrophotometric method) at 239 nm, method B (first-order spectrophotometric method) at 231 nm, and method C (area under the curve spectrophotometric method) at 230 to 248 nm. The method's validation and stress degradation studies were done following the International Conference on Harmonization (ICH) guidelines.
Results: The methods were validated using the prescribed parameters like system suitability, LOD, LOQ, accuracy, precision, robustness, specificity, etc. The relative standard deviation (% RSD) of the peak area observed in each case was found within the accepted range (<2%). The linearity study's coefficient of correlation (R2) value was<0.99. The methods were quantified accurately in the presence of degraded products.
Conclusion: The developed simple and economical method is a suitable option for the qualitative and quantitative study of capecitabine in bulk and tablets, even in its degraded products, which may arise because of oxidation, hydrolysis, thermal, and photolytic decomposition.
DESIGN, DEVELOPMENT AND FABRICATION OF MOUTH-DISSOLVING TABLETS CONTAINING EXTRACT OF TRIBULUS TERRESTRIS FOR THE TREATMENT OF HYPERTENSION
Authors: BARDE LOKESH , SURUSE PRAVIN , AGRAWAL SHWETA , KALKOTWAR RAMESH , SABLE VIJAYSINH , TARE HARSHAL
Published: May 2023

Objective: The present work is aim to design, development and fabrication of mouth dissolving tablets containing extract of Tribulus terrestris for the treatment of hypertension.
Methods: The extract of fruits of Tribulus terrestris was formulated as mouth dissolving tablets (MDTs) by full factorial design at 32 levels and prepared by direct compression method using super integrants like sodium starch glycolate and cross povidone. Furthermore, the tablet was evaluated for thickness, hardness, weight variation, wetting time, disintegration time, and in vitro drug release study.
Results: The tablets were analyzed for a variety of characteristics, such as hardness (2.4-2.9 kg/cm2), friability (0.33-1.7%), disintegration time (20-34 s), drug content (95.32-99.09%), water uptake ratio (26-48%), wetting time (29-69 s), and in vitro drug release illustrated in 5 min (99.04-68.21%). There was no interaction between both the drug and the polymer, according to FTIR and DSC studies.
Conclusion: The research revealed that Tribulus terrestris fruits extract can be designed, developed and fabricated into mouth dissolving tablet for the treatment of hypertension with improved bioavailability and expected patient compliance.
THE DEVELOPMENT AND VALIDATION OF A FAST STABILITY INDICATING RP-HPLC METHOD FOR QUANTIFICATION OF LUMEFANTRINE AND ITS ORGANIC IMPURITIES USING CENTRAL COMPOSITE EXPERIMENTAL DESIGN
Authors: RAMESH G. TARAKA , PRASAD Y. RAJENDRA
Published: May 2023

Objective: The objective of the present study was to develop and validate a stability indicating RP-HPLC method for Lumefantrine (LF) and its organic impurities using a central composite design (CCD).
Methods: A specific, simple quality control friendly isocratic elution method using reverse phase HPLC was developed for quantification of Lumefantrine (LF) and its organic impurities at a wavelength of 265 nm. The chromatographic separation was achieved on the column of Thermo Hypersil ODS C18 (150x4.6 mm, 3µ) with a buffer containing 0.1percent formic acid and acetonitrile 10:90 v/v as a mobile phase with a flow rate of 1.6 ml/min at 35 °C with a run time of 10 min. Based on the preliminary trials, CCD was employed to check the effect of independent variables such as Acetonitrile ratio (A), Flow rate (B), and Column oven temperature (C). While resolution between Lumefantrine (LF) and Impurity-A (X1), Impurity-A and Impurity-B (X2), and Plate count of Lumefantrine (LF) (X3) were considered as dependent variables and statistical evaluation performed by using design expert software. The optimized conditions were validated as per ICH guidelines.
Results: The retention time of LF and its organic impurities were 1.9 min, 3.0, 4.5, and 6.4 min, respectively. Design space was established and desirability was found. LOD and LOQ for the Lumefantrine (LF) and its impurities were established with respect to test concentration. The plotted calibration curves were linear with a regression coefficient of R2>0.99, indicating that the linearity was within the limit. As a part of method validation, the parameters like Specificity with forced degradation, Linearity, Precision, Accuracy, Ruggedness, and Robustness were determined and the results were found to be within the allowable limits.
Conclusion: The method developed and validated was found to be suitable for routine analysis and to be used for the measurement of Lumefantrine and its impurities. Since there is no stability indicating the RP-HPLC method with design space was reported in the literature, there is a need to develop quantitative methods under different conditions to achieve improvement in specificity and selectivity.
Used Car Price Prediction Using Machine Learning
Authors: S Raghav , R Bharath T , T Bharath G , Hegde Ravi Prakash , Ramesh Sohan
Published: May 2023

Abstract: Due to the unprecedented number of cars being purchased and sold, used car price prediction is a topic of high interest. Because of the affordability of used cars in developing countries, people tend more purchase used cars. A primary objective of this project is to estimate used car prices by using attributes that are highly correlated with a label (Price). The aim of this project is to develop a model for predicting the prices ofused cars. The study uses two popular regression algorithms, Random Forest and Linear Regression. Thedata used in the project is obtained from various sources and includes information about the make and model of the car, its mileage, age, and other factors that affect its price. The study evaluates the performance of the models using metrics such as Mean Absolute Error, Mean Squared Error, and R-Squared. Theresults show that both Random Forest and Linear Regression models can accurately predict used car prices, with Random Forest performing slightly better. The study provides valuable insights into the factors that influence the prices of used cars and can assist car dealerships, buyers, and sellers in making informed decisions then the model will be integrated into a webpage for general public to use.
Autoevaluación y Mejoramiento continuo en el programa Administración en Salud con fines de acreditación, Colombia 2021
Authors: Petro Falón Luz Neyla , Espitia Cabralez Enalbis Ester , Montoya Vega Martha Elena
Published: May 2023

Introducción: La autoevaluación de la calidad de la educación superior es una estrategia para la mejora continua en todos los niveles. El direccionamiento del Ministerio de Educación permite seguir una ruta adecuada y comparar estándares alcanzados con los deseados. Objetivo: describir la mejora continua producto de los procesos de autoevaluación en el programa Administración en Salud de la Universidad de Córdoba, 2011 a 2020. Metodología: estudio descriptivo, retrospectivo mixto aplicando una lista de chequeo mediante observación y recolección de documentos como evidencia de cumplimiento de características. Encuesta electrónica para obtener información de percepción de procesos y procedimientos. Resultados: Los factores: Misión y Proyecto educativo institucional tiene un cumplimiento superior al 90%; Estudiantes 100%, Docentes pasó del 81 al 93,7%; Procesos Académicos de 76 a 88%; Bienestar Universitario, Internacionalización e Investigación de 92 a 94%. Además, se han logrado avances en el número y cualificación docente, aumento en la investigación formativa y prácticas desarrolladas, avances en la productividad académica reflejada en el número de trabajos de investigación, artículos, capítulos de libro, grupo de investigación reconocido por Minciencias, aumento en número de ponencias, realización de encuentro de egresados y de eventos académicos organizados por y para estudiantes y egresados del programa Mejora en resultados Saber Pro. Conclusiones: Entre los beneficios de los procesos de acreditación institucional se fortalece la cultura de la autoevaluación y mejoramiento continuo. Trámites de obtención y/o renovación del registro calificado de oficio o vía administrativa por parte del Ministerio de Educación Nacional. Puntos adicionales en los criterios de evaluación de convocatorias públicas para proyectos de investigación. Puntos adicionales para convocatorias laborales y concursos para nuestros graduados. Participación de la Universidad en convocatorias públicas de instituciones públicas o privadas para la aplicación de pruebas de conocimiento para la elección de secretario general de concejo municipal, distrital y asambleas, personero municipal, contralor municipal, distrital y departamental.
Oil-exchange rate volatilities and returns nexus
Authors: Umoru David , Effiong Solomon Edem , Okpara Enyinna , Eke Robert Ike , Iyayi Davidson , Nwonu Cletus Ukon , Obomeghie Muhammed Adamu , Tizhe Anna Nuhu , Eshemogie Kasimu
Published: May 2023

The study evaluates the channel of volatilities and returns between global oil prices and exchange rates of 21 developing countries. The structural vector autoregression (SVAR) findings are that oil-producing and exporting countries would have their exchange rates fluctuate slightly due to changing oil prices. For Markov-regime switching estimations, whereas, exchange rate volatility does not significantly influence volatility in oil prices at both regimes of flexible and fixed exchange rates, there is the presence of significant volatility spill-over from oil prices to exchange rates. Oil price movements do significantly induce appreciation or depreciation of exchange rates. In effect, volatilities in exchange rates do not trigger volatilities in oil prices but positively and considerably influenced crude oil returns in the fixed regime by 0.59%. Notwithstanding the 0.092 low transition probability, all other probabilities that the influence of volatility in the exchange rate on oil market volatility would persist are high for both flexible and fixed regimes of exchange rates. The significant positive coefficients of exchange rates together with high transition probabilities reported are indicative of rising exchange rates, implying devaluation and hence, a negative influence on oil returns and prices. Market agents can therefore diversify risks by investing in oil markets and forex markets independently.
Tittle Page POCUS versus chest X-ray in high frequency oscillatory ventilation
Authors: Sahin Ozlem , Colak Derya , Kalin Sevinc , Atay Funda Yavanoglu , Guran Omer , Akin Ilke Mungan
Published: May 2023

Introduction: The most prevalent method for evaluating lung
expansion in high-frequency oscillatory ventilation (HFOV) is chest
X-ray (CXR). The purpose of this study was to compare the accuracy of
chest radiography with point-of-care ultrasound (POCUS) in determining
lung expansion. Methods: This prospective study included
newborns who required HFOV and were being monitored in the Neonatal
Intensive Care Unit. A single neonatologist assessed lung expansion with
a chest x-ray and POCUS, to measure the costal level of the right
hemidiaphragm and compare the results. Results: A neonatologist
took 55 measurements on 28 newborns with a gestational age of 32
(23.2-39.4) weeks who were followed on HFOV. The rib counts obtained
from anterior chest ultrasonography and posterior CXR showed a
statistically high concordance (p<0.05). Conclusions:
Lung ultrasonography is a reliable method in the evaluation of lung
expansion in patients followed on HFOV.