bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Tables S1-S7 from Modeling Lung Cancer Evolution and Preclinical Response by Orthotopic Mouse Allografts
Authors: Ambrogio Chiara , Carmona Francisco J. , Vidal August , Falcone Mattia , Nieto Patricia , Romero Octavio A. , Puertas Sara , Vizoso Miguel , Nadal Ernest , Poggio Teresa , Sánchez-Céspedes Montserrat , Esteller Manel , Mulero Francisca , Voena Claudia , Chiarle Roberto , Barbacid Mariano , Santamaría David , Villanueva Alberto
Published: March 2023

Supplementary Tables S1-S7. K-RasG12V tumors serially transplanted in Crl:NU-Foxn1nu mice and paired derived cell lines (S1); Semiquantitative assessment of the percentages of histologic components in passage #1 engrafted tumors (S2); EML4-ALK tumors orthotopically implanted in Crl:NU-Foxn1nu mice (S3); Histologic progression of orthoallografts upon sequential mice-to-mice passages (S4); Presence of distal metastasis in animals implanted with the indicated orthoallografts (S5); Summary of primary cell lines obtained from the indicated orthoallograft implants (S6); Histopathological characterization of EML4-ALK implants after crizotinib treatment (S7).
Supplementary Figure S4 from β-Catenin Contributes to Lung Tumor Development Induced by EGFR Mutations
Authors: Nakayama Sohei , Sng Natasha , Carretero Julian , Welner Robert , Hayashi Yuichiro , Yamamoto Mihoko , Tan Alistair J. , Yamaguchi Norihiro , Yasuda Hiroyuki , Li Danan , Soejima Kenzo , Soo Ross A. , Costa Daniel B. , Wong Kwok-Kin , Kobayashi Susumu S.
Published: March 2023

Tyrosine-phosphorylation of β-catenin Y-F mutants.
Supplementary Figure S1 from β-Catenin Contributes to Lung Tumor Development Induced by EGFR Mutations
Authors: Nakayama Sohei , Sng Natasha , Carretero Julian , Welner Robert , Hayashi Yuichiro , Yamamoto Mihoko , Tan Alistair J. , Yamaguchi Norihiro , Yasuda Hiroyuki , Li Danan , Soejima Kenzo , Soo Ross A. , Costa Daniel B. , Wong Kwok-Kin , Kobayashi Susumu S.
Published: March 2023

Higher expression of nuclear β-catenin in cells with EGFR activating mutations.
Supplementary Table 3 from Activated d16HER2 Homodimers and SRC Kinase Mediate Optimal Efficacy for Trastuzumab
Authors: Castagnoli Lorenzo , Iezzi Manuela , Ghedini Gaia C. , Ciravolo Valentina , Marzano Giulia , Lamolinara Alessia , Zappasodi Roberta , Gasparini Patrizia , Campiglio Manuela , Amici Augusto , Chiodoni Claudia , Palladini Arianna , Lollini Pier Luigi , Triulzi Tiziana , Menard Sylvie , Nanni Patrizia , Tagliabue Elda , Pupa Serenella M.
Published: March 2023

73 genes composing the "activated-d16HER2 signature".
Supplementary Figure S2 from Activated d16HER2 Homodimers and SRC Kinase Mediate Optimal Efficacy for Trastuzumab
Authors: Castagnoli Lorenzo , Iezzi Manuela , Ghedini Gaia C. , Ciravolo Valentina , Marzano Giulia , Lamolinara Alessia , Zappasodi Roberta , Gasparini Patrizia , Campiglio Manuela , Amici Augusto , Chiodoni Claudia , Palladini Arianna , Lollini Pier Luigi , Triulzi Tiziana , Menard Sylvie , Nanni Patrizia , Tagliabue Elda , Pupa Serenella M.
Published: March 2023

Enrichment plots of significantly enriched gene sets for the comparison between active d16HER2 tumors and inactive or negative d16HER2 tumors.
Supplementary Figure S1 from Activated d16HER2 Homodimers and SRC Kinase Mediate Optimal Efficacy for Trastuzumab
Authors: Castagnoli Lorenzo , Iezzi Manuela , Ghedini Gaia C. , Ciravolo Valentina , Marzano Giulia , Lamolinara Alessia , Zappasodi Roberta , Gasparini Patrizia , Campiglio Manuela , Amici Augusto , Chiodoni Claudia , Palladini Arianna , Lollini Pier Luigi , Triulzi Tiziana , Menard Sylvie , Nanni Patrizia , Tagliabue Elda , Pupa Serenella M.
Published: March 2023

Flow cytometry analysis of live transgenically expressed MI6 and WTHER2 tumor cell lines.
Supplementary Figure Legends from Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis
Authors: Gopinathan Lakshmi , Tan Shawn Lu Wen , Padmakumar V. C. , Coppola Vincenzo , Tessarollo Lino , Kaldis Philipp
Published: March 2023

PDF file - 100KB
Supplementary Figure 6 from Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis
Authors: Gopinathan Lakshmi , Tan Shawn Lu Wen , Padmakumar V. C. , Coppola Vincenzo , Tessarollo Lino , Kaldis Philipp
Published: March 2023

PDF file - 93KB, Defective and error-prone recovery from quiescence in late passage Cdk2nullcyclin A2null cells.
Supplementary Methods from Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition
Authors: Mimura Naoya , Hideshima Teru , Shimomura Toshiyasu , Suzuki Rikio , Ohguchi Hiroto , Rizq Ola , Kikuchi Shohei , Yoshida Yasuhiro , Cottini Francesca , Jakubikova Jana , Cirstea Diana , Gorgun Gullu , Minami Jiro , Tai Yu-Tzu , Richardson Paul G. , Utsugi Teruhiro , Iwama Atsushi , Anderson Kenneth C.
Published: March 2023

PDF file - 300K
Supplementary Figure 3 from Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis
Authors: Gopinathan Lakshmi , Tan Shawn Lu Wen , Padmakumar V. C. , Coppola Vincenzo , Tessarollo Lino , Kaldis Philipp
Published: March 2023

PDF file - 171KB, Deletion of cyclin A2 in growing tumors and confirmation of cyclin A2 deletion during 3T3 assays.
Supplementary Figures Legend from BRCA1 Suppresses Epithelial-to-Mesenchymal Transition and Stem Cell Dedifferentiation during Mammary and Tumor Development
Authors: Bai Feng , Chan Ho Lam , Scott Alexandria , Smith Matthew D. , Fan Cheng , Herschkowitz Jason I. , Perou Charles M. , Livingstone Alan S. , Robbins David J. , Capobianco Anthony J. , Pei Xin-Hai
Published: March 2023

Legends for Supplementary Figures 1-9.
Supplementary Figure 2 from EWS–WT1 Oncoprotein Activates Neuronal Reprogramming Factor ASCL1 and Promotes Neural Differentiation
Authors: Kang Hong-Jun , Park Jun Hong , Chen WeiPing , Kang Soo Im , Moroz Krzysztof , Ladanyi Marc , Lee Sean Bong
Published: March 2023

PDF file - 176K, Expression of E-KTS activates ASCL1 expression.
Supplementary Figure 1 from EWS–WT1 Oncoprotein Activates Neuronal Reprogramming Factor ASCL1 and Promotes Neural Differentiation
Authors: Kang Hong-Jun , Park Jun Hong , Chen WeiPing , Kang Soo Im , Moroz Krzysztof , Ladanyi Marc , Lee Sean Bong
Published: March 2023

PDF file - 54K, Generation of conditional EWS-WT1 knock-in mice.
Data Supplement from TRIM29 Suppresses TWIST1 and Invasive Breast Cancer Behavior
Authors: Ai Lingbao , Kim Wan-Ju , Alpay Merve , Tang Ming , Pardo Carolina E. , Hatakeyama Shigetsugu , May W. Stratford , Kladde Michael P. , Heldermon Coy D. , Siegel Erin M. , Brown Kevin D.
Published: March 2023

Table S1: Oligonucleotide primer sequences. Table S2: Data obtained from the Cox model. Figure S1: Detailed structure of the human TRIM29 gene locus. Figure S2: Additional TRIM29 gene methylation and transcript abundance analysis. Figure S3: Analysis of gene expression in breast cancer cells with TRIM29 knockdown. Figure S4: qRT-PCR analysis of TWIST1 and N-cadherin mRNA abundance in TRIM29 knockdown and control SK-BR-3 cells. Figure S5: Results of multivariate survival analysis examining TRIM29 expression vs patient age (A), lymph node status (B), size (C), Grade (D), and ER status (E).
Supplementary figures legends from Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy
Authors: Le Kieu-Suong , Thibult Marie-Laure , Just-Landi Sylvain , Pastor Sonia , Gondois-Rey Françoise , Granjeaud Samuel , Broussais Florence , Bouabdallah Reda , Colisson Renaud , Caux Christophe , Ménétrier-Caux Christine , Leroux Dominique , Xerri Luc , Olive Daniel
Published: March 2023

This file contains legends of 3 Supplementary Figures Supplementary Figure S1:ICOSL expression on immune cells in lymphoma and on cell line by flow cytometry Supplementary Figure S2: Antagonist anti-ICOS Abs favor upregulation of ICOSL on FL B cells and on murine B cells Supplementary Figure S3: Inhibition of FL B cells proliferation by Tregs
Supplementary figures and tables from Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy
Authors: Le Kieu-Suong , Thibult Marie-Laure , Just-Landi Sylvain , Pastor Sonia , Gondois-Rey Françoise , Granjeaud Samuel , Broussais Florence , Bouabdallah Reda , Colisson Renaud , Caux Christophe , Ménétrier-Caux Christine , Leroux Dominique , Xerri Luc , Olive Daniel
Published: March 2023

This file contains 3 Supplementary Figures and 1 supplementary table Supplementary Figure S1:ICOSL expression on immune cells in lymphoma and on cell line by flow cytometry Supplementary Figure S2: Antagonist anti-ICOS Abs favor upregulation of ICOSL on FL B cells and on murine B cells Supplementary Figure S3: Inhibition of FL B cells proliferation by Tregs Supplemntary Table S1: Monoclonal antibodies used for flow cytometry
Data Supplement from Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Authors: Yori Jennifer L. , Lozada Kristen L. , Seachrist Darcie D. , Mosley Jonathan D. , Abdul-Karim Fadi W. , Booth Christine N. , Flask Chris A. , Keri Ruth A.
Published: March 2023

Supplementary Figure S1. Activation levels of Src (p-Src) are not correlated with mTOR pathway activation (p-S6) across multiple breast cancer subtypes.
Data Supplement from Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Authors: Yori Jennifer L. , Lozada Kristen L. , Seachrist Darcie D. , Mosley Jonathan D. , Abdul-Karim Fadi W. , Booth Christine N. , Flask Chris A. , Keri Ruth A.
Published: March 2023

Supplementary Figure S3. Analysis of mTOR and AKT signaling in breast cancer cell lines treated with dasatinib and rapamycin.
Data Supplement from Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Authors: Yori Jennifer L. , Lozada Kristen L. , Seachrist Darcie D. , Mosley Jonathan D. , Abdul-Karim Fadi W. , Booth Christine N. , Flask Chris A. , Keri Ruth A.
Published: March 2023

Supplementary Figure S8. Dasatinib inhibits pulmonary metastases in MMTV-PYMT tumor bearing mice.
Data Supplement from Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Authors: Yori Jennifer L. , Lozada Kristen L. , Seachrist Darcie D. , Mosley Jonathan D. , Abdul-Karim Fadi W. , Booth Christine N. , Flask Chris A. , Keri Ruth A.
Published: March 2023

Legends for Supplementary Figures S1-S8.
Supplementary Figure S5 from TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors
Authors: Condelli Valentina , Piscazzi Annamaria , Sisinni Lorenza , Matassa Danilo Swann , Maddalena Francesca , Lettini Giacomo , Simeon Vittorio , Palladino Giuseppe , Amoroso Maria Rosaria , Trino Stefania , Esposito Franca , Landriscina Matteo
Published: March 2023

Schematic representation of the transcriptional interactions among 6 cell cycle-related genes down-regulated in shTRAP1 cells according to the whole genome gene expression analysis and confirmed by subsequent Real Time validation analysis (query genes, visualized in green) and MAPK pathway (visualized in red). Transcriptional interactions from IPA software.
Supplementary Figure S1 from TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors
Authors: Condelli Valentina , Piscazzi Annamaria , Sisinni Lorenza , Matassa Danilo Swann , Maddalena Francesca , Lettini Giacomo , Simeon Vittorio , Palladino Giuseppe , Amoroso Maria Rosaria , Trino Stefania , Esposito Franca , Landriscina Matteo
Published: March 2023

TRAP1 silencing results in reduced BRAF-wt or V600E protein levels, attenuation of ERK phosphorylation and cell cycle progression. A-B. Total cell lysates from serum-starved COLO320 cells transfected with negative or TRAP1 siRNA and further serum stimulated for 1 and 3h (A) or from scramble and shTRAP1 MCF7 cells transfected with BRAF-wt or BRAF-V600E constructs were separated by SDS-PAGE and immunoblotted with indicated antibodies. C-D. Cell cycle distribution in MCF7 (C) and COLO320 (D) cells transfected with negative or TRAP1 siRNA. Inserts: Total cell lysates from MCF7 (C) and COLO320 (D) cells transfected with negative or TRAP1 siRNA were separated by SDS-PAGE and immunoblotted with indicated antibodies.
Supplementary Tables from Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer
Authors: Tripathi Manish K. , Deane Natasha G. , Zhu Jing , An Hanbing , Mima Shinji , Wang Xiaojing , Padmanabhan Sekhar , Shi Zhiao , Prodduturi Naresh , Ciombor Kristen K. , Chen Xi , Washington M. Kay , Zhang Bing , Beauchamp R. Daniel
Published: March 2023

Supplementary Tables. All tables containing supplementary data for publication as referenced in the manuscript
Supplementary File 3 from Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer
Authors: Tripathi Manish K. , Deane Natasha G. , Zhu Jing , An Hanbing , Mima Shinji , Wang Xiaojing , Padmanabhan Sekhar , Shi Zhiao , Prodduturi Naresh , Ciombor Kristen K. , Chen Xi , Washington M. Kay , Zhang Bing , Beauchamp R. Daniel
Published: March 2023

Supplementary File 3. Sixty-three core genes from the mouse metastatic model that are enriched in the developmental co-expression module
Supplementary Information from In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
Authors: Santos Mirentxu , Martínez-Fernández Mónica , Dueñas Marta , García-Escudero Ramón , Alfaya Begoña , Villacampa Felipe , Saiz-Ladera Cristina , Costa Clotilde , Oteo Marta , Duarte José , Martínez Victor , Gómez-Rodriguez Ma José , Martín Ma Luisa , Fernández Manoli , Viatour Patrick , Morcillo Miguel A. , Sage Julien , Castellano Daniel , Rodriguez-Peralto Jose L. , de la Rosa Federico , Paramio Jesús M
Published: March 2023

Supplementary Information. Supplementary Methods Supplementary Figures 1-6. Supp Fig. 1: Identification of bladder tumors by Computerized tomography (CT). Supp Fig 2: Determination of effective elimination of pRb and p130 in bladder tumors. Supp Fig 3: Expression of E2F1, E2F2 and E2F3a genes in mouse bladder tumors. Supp Fig 4: Polycomb-bound genes associate with early recurrence in external datasets of bladder cancer. Supp Fig. 5: Expression of SUZ12 and EED genes in human NMIBC. Supp Fig 6: Expression of E2F1, 2 and 3b genes in human NMIBC. Supplementary Tables 1, 7, 8, 9, 13 and 14. Supp Table 1: Sequence of the Oligonucleotides used in PCR analysis. Supp Table 7: Gene Set Enrichment Analysis of the deregulated genes in mouse bladder tumors. Supp Table 8: Overlap between the downregulated genes in mouse bladder tumors and human bladder cancer datasets from Oncomine database. Supp Table 9: Overlap between the upregulated genes in mouse bladder tumors and human bladder dataset from Oncomine database. Supp Table 13: Gene Set Enrichment Analysis of the deregulated genes in human recurrent bladder tumors. Supp Table 14: Overlap between the upregulated genes in our series of human recurrent bladder tumors and human bladder cancer datasets from Oncomine database. Supplementary References
Supp Table S6 from In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
Authors: Santos Mirentxu , Martínez-Fernández Mónica , Dueñas Marta , García-Escudero Ramón , Alfaya Begoña , Villacampa Felipe , Saiz-Ladera Cristina , Costa Clotilde , Oteo Marta , Duarte José , Martínez Victor , Gómez-Rodriguez Ma José , Martín Ma Luisa , Fernández Manoli , Viatour Patrick , Morcillo Miguel A. , Sage Julien , Castellano Daniel , Rodriguez-Peralto Jose L. , de la Rosa Federico , Paramio Jesús M
Published: March 2023

Supp Table S6. Transcription factor analyzed by Chip Enrichment analysis of the upregulated genes in mouse bladder tumors.
Data Supplement from Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer
Authors: Tripathi Manish K. , Deane Natasha G. , Zhu Jing , An Hanbing , Mima Shinji , Wang Xiaojing , Padmanabhan Sekhar , Shi Zhiao , Prodduturi Naresh , Ciombor Kristen K. , Chen Xi , Washington M. Kay , Zhang Bing , Beauchamp R. Daniel
Published: March 2023

Data Supplement from Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer
Data Supplement from Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors
Authors: Nishio Nobuhiro , Diaconu Iulia , Liu Hao , Cerullo Vincenzo , Caruana Ignazio , Hoyos Valentina , Bouchier-Hayes Lisa , Savoldo Barbara , Dotti Gianpietro
Published: March 2023

Supplementary Figure S4. Growth of CHLA-255 cells in mice inoculated in both flanks
Data Supplement from Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors
Authors: Nishio Nobuhiro , Diaconu Iulia , Liu Hao , Cerullo Vincenzo , Caruana Ignazio , Hoyos Valentina , Bouchier-Hayes Lisa , Savoldo Barbara , Dotti Gianpietro
Published: March 2023

Supplementary Legends. Legends for Supplementary Figures, Tables and Movies.
Data Supplement from Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors
Authors: Nishio Nobuhiro , Diaconu Iulia , Liu Hao , Cerullo Vincenzo , Caruana Ignazio , Hoyos Valentina , Bouchier-Hayes Lisa , Savoldo Barbara , Dotti Gianpietro
Published: March 2023

Supplementary Movie 1D. Ad5ÃŽ?24 and GD2.CAR-T cell
Supplementary Figures 1 - 5 from Discrepancies in Cancer Genomic Sequencing Highlight Opportunities for Driver Mutation Discovery
Authors: Hudson Andrew M. , Yates Tim , Li Yaoyong , Trotter Eleanor W. , Fawdar Shameem , Chapman Phil , Lorigan Paul , Biankin Andrew , Miller Crispin J. , Brognard John
Published: March 2023

Supplementary Figure 1. Original comparison of 18 cell lines sequenced by COSMIC and CCLE to display that the conformity of missense mutation detection ranges from 56.75% in HCC2218 cell line to 12.90% in HCC1954. Supplementary Figure 2. Bamfile images of the CRUK MI sequencing shows good read coverage with the PAK4 p.E119Q mutation in 51% of reads compared to CCLE hybrid capture bamfiles of the same area with only 2 reads and neither read showing a mutation. Supplementary Figure 3. Western Blot showing empty vector, PAK4 wildtype, and p.E119Q mutant overexpression in 293T cells with the mutant showing enhanced ERK phosphorylation but no effect on JNK phosphorylation. Supplementary Figure 4. Chart demonstrating an increase in conformity of reported mutations when the CCLE data that has not been filtered for germ line SNPs is used. Supplementary Figure 5. Comparison of mutation detection in four cell lines between COSMIC, CCLE and our own institute (CRUK MI) reveals 29.41% of mutations are missed by CRUK MI but the discrepancy decreases to 17.65% when the comparison is repeated with CRUK MI data that has not been filtered for germ line SNPs.
Supplemental Figures S1-S8 from Homeoprotein Six2 Promotes Breast Cancer Metastasis via Transcriptional and Epigenetic Control of E-Cadherin Expression
Authors: Wang Chu-An , Drasin David , Pham Catherine , Jedlicka Paul , Zaberezhnyy Vadym , Guney Michelle , Li Howard , Nemenoff Raphael , Costello James C. , Tan Aik-Choon , Ford Heide L.
Published: March 2023

Supplemental Figures S1-S8. SIX2 is overexpressed in breast cancer and correlates with poor prognosis (S1); Six2 KD does not affect proliferation or levels of VEGF-C (S2); Six2 overexpression in 4TO7 cells alters cell morphology but does not increase cell proliferation (S3); Six2 expression in 4TO7 cells increases lung metastasis (S4); Six2 overexpression leads to Zeb2 upregulation in 4TO7 and HMLE cells (S5); SIX2 downregulates miR-8 family members, which when restored to SIX2 overexpressing cells, can reverse the SIX2-induced upregulation of Zeb2 (S6); High levels of SIX2 are found in breast cancer cell lines exhibiting E-cadherin hypermethylation and silencing (S7); SIX2 expression inversely correlates with CDH1 expression in triple negative and non-triple negative breast cancers (S8).
Supplementary Table S8 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

Intersecting top 5% of mutated genes based on the proportion of affected samples between CRC cell lines and TCGA-analyzed primary cancers for non-hypermutated and hypermutated MSI-H samples.
Supplementary Table S5 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

Significantly altered focal regions of chromosomal deletion or gain/amplification for 63 unique CRC cell lines and 213 TCGA-analyzed primary cancers stratified into non-hypermutated and hypermutated MSI-H cases. Minimal focal regions were deduced using OncoSNP v2.18 suite and GISTIC2.0.
Data Supplement from Ubiquitin-like Protein FAT10 Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Modifying β-Catenin Degradation
Authors: Yuan Rongfa , Wang Kai , Hu Junwen , Yan Chen , Li Ming , Yu Xin , Liu Xiuxia , Lei Jun , Guo Wuhua , Wu Linquan , Hong Kui , Shao Jianghua
Published: March 2023

Supplementary Material,Methods and Figures Legends
Supplementary Figure 1 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

PDF file - 137KB, Correlation between RNA-Seq and gene expression microarray data (Affymetrix U133 Plus2.0 Arrays) for six CRC cell lines analyzed in independent experiments. Genes with detectable expression on both platforms were considered, defined as RNA-Seq RPKM value >1 and microarray intensity > log2(100). r-values, Spearman's rank correlation coefficient.
Supplementary Data and Methods from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

Supplementary Data and Methods
Data Supplement from Ubiquitin-like Protein FAT10 Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Modifying β-Catenin Degradation
Authors: Yuan Rongfa , Wang Kai , Hu Junwen , Yan Chen , Li Ming , Yu Xin , Liu Xiuxia , Lei Jun , Guo Wuhua , Wu Linquan , Hong Kui , Shao Jianghua
Published: March 2023

Supplementary Figure S1. The FAT10, HOXB9, and β-catenin expression decreased after the transfection of the corresponding shRNA plasmids.
Supplementary Table 1 from The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors
Authors: Izumchenko Evgeny , Chang Xiaofei , Michailidi Christina , Kagohara Luciane , Ravi Rajani , Paz Keren , Brait Mariana , Hoque Mohammad O. , Ling Shizhang , Bedi Atul , Sidransky David
Published: March 2023

PDF file - 2202KB, Summary of EGFR, KRAS, NRAS and P53 mutation status in 18 human NSCLCs and 27 pancreatic directly xenografted low passage tumors.
Supplementary Figure Legends from The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors
Authors: Izumchenko Evgeny , Chang Xiaofei , Michailidi Christina , Kagohara Luciane , Ravi Rajani , Paz Keren , Brait Mariana , Hoque Mohammad O. , Ling Shizhang , Bedi Atul , Sidransky David
Published: March 2023

PDF file - 197KB
Data Supplement from Ubiquitin-like Protein FAT10 Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Modifying β-Catenin Degradation
Authors: Yuan Rongfa , Wang Kai , Hu Junwen , Yan Chen , Li Ming , Yu Xin , Liu Xiuxia , Lei Jun , Guo Wuhua , Wu Linquan , Hong Kui , Shao Jianghua
Published: March 2023

Supplementary Figure S3. Downregulation of FAT10 inhibited HCC cell migration and invasion by suppressing HOXB9 expression in Huh-7 cells.
Supplementary Figure 2 from The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors
Authors: Izumchenko Evgeny , Chang Xiaofei , Michailidi Christina , Kagohara Luciane , Ravi Rajani , Paz Keren , Brait Mariana , Hoque Mohammad O. , Ling Shizhang , Bedi Atul , Sidransky David
Published: March 2023

PDF file - 108KB, TGFbeta induces EMT-associated kinase switch promotes erlotinib-resistance of tumor cells. A. Erlotinib sensitive cell lines H292 and SCC-S were treated with TGFβ1 (4 ng/ml) for 21 days and immunoblot analysis was performed with indicated antibodies. B. Parental and TGFbeta-induced H358 and SCC-S cells were treated with erlotinib for 72 hours and cell viability was assayed. Values were set at 100% for untreated controls. C. Protein lysates were extracted from H358 and SCC-S cells treated or untreated with TGFbeta for 21 days and immunoblot analysis was performed with antibodies against indicated phospho RTKs. Beta-actin was used as a loading control.
Supplementary Figure S4 from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
Authors: Kharma Budiman , Baba Tsukasa , Matsumura Noriomi , Kang Hyun Sook , Hamanishi Junzo , Murakami Ryusuke , McConechy Melissa M. , Leung Samuel , Yamaguchi Ken , Hosoe Yuko , Yoshioka Yumiko , Murphy Susan K. , Mandai Masaki , Hunstman David G. , Konishi Ikuo
Published: March 2023

Supplementary Figure S4. Stable knockdown of STAT1 expression.
Supplemental Figure Legends from Long-Chain Fatty Acid Analogues Suppress Breast Tumorigenesis and Progression
Authors: Gluschnaider Udi , Hertz Rachel , Ohayon Sarit , Smeir Elia , Smets Martha , Pikarsky Eli , Bar-Tana Jacob
Published: March 2023

Supplemental Figure Legends. Legends for Supplemental Figures S1-S3.
Supplementary Figure S2 from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
Authors: Kharma Budiman , Baba Tsukasa , Matsumura Noriomi , Kang Hyun Sook , Hamanishi Junzo , Murakami Ryusuke , McConechy Melissa M. , Leung Samuel , Yamaguchi Ken , Hosoe Yuko , Yoshioka Yumiko , Murphy Susan K. , Mandai Masaki , Hunstman David G. , Konishi Ikuo
Published: March 2023

Supplementary Figure S2. Comparison of STAT1 mRNA expression among histological subtypes of endometrial cancers.
Supplementary Figure 2 from Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer
Authors: Gardner Eric E. , Connis Nick , Poirier John T. , Cope Leslie , Dobromilskaya Irina , Gallia Gary L. , Rudin Charles M. , Hann Christine L.
Published: March 2023

PDF file - 527KB, Supplemental Figure 2. Rapamycin responses in a panel of SCLC cell lines and synergy matrix plots of ABT-737 plus inhibitors of PI3K and mTOR in SCLC cell lines.
Supplementary Figure 7 from GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
Authors: De Francesco Ernestina Marianna , Pellegrino Michele , Santolla Maria Francesca , Lappano Rosamaria , Ricchio Emilia , Abonante Sergio , Maggiolini Marcello
Published: March 2023

PDF file - 134KB, Supplementary Figure S7: Histological analysis of SkBr3 tumor xenografts.
Supplementary Figure 3 from GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
Authors: De Francesco Ernestina Marianna , Pellegrino Michele , Santolla Maria Francesca , Lappano Rosamaria , Ricchio Emilia , Abonante Sergio , Maggiolini Marcello
Published: March 2023

PDF file - 60KB, Supplementary Figure S3: Efficacy of GPER and HIF-1alpha silencing.
Supplementary Figure 1 from GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
Authors: De Francesco Ernestina Marianna , Pellegrino Michele , Santolla Maria Francesca , Lappano Rosamaria , Ricchio Emilia , Abonante Sergio , Maggiolini Marcello
Published: March 2023

PDF file - 46KB, Supplementary Figure S1: estrogen receptor (ER)alpha and ERbeta expression and E2 production.
Supplemental Figure 2 from Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
Authors: Cekic Caglar , Linden Joel
Published: March 2023

Supplementary Figure 2. Effects of T cell selective A2AR-deletion on B16F10 growth.
Supplementary Tables 1 - 3 from NQO1 Suppresses NF-κB–p300 Interaction to Regulate Inflammatory Mediators Associated with Prostate Tumorigenesis
Authors: Thapa Dinesh , Meng Peng , Bedolla Roble G. , Reddick Robert L. , Kumar Addanki P. , Ghosh Rita
Published: March 2023

(S1) List of primer pairs used in qPCR, (S2) list of upregulated genes following NQO1 KD, (S3) list of down-regulated genes following NQO1 KD.
Supplementary Table 1 from No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer
Authors: Anantharaman Devasena , Gheit Tarik , Waterboer Tim , Halec Gordana , Carreira Christine , Abedi-Ardekani Behnoush , McKay-Chopin Sandrine , Zaridze David , Mukeria Anush , Szeszenia-Dabrowska Neonila , Lissowska Jolanta , Mates Dana , Janout Vladimir , Foretova Lenka , Bencko Vladimir , Rudnai Peter , Fabianova Eleonora , Tjønneland Anne , Travis Ruth C. , Boeing Heiner , Quirós J. Ramón , Johansson Mikael , Krogh Vittorio , Bueno-de-Mesquita H. Bas , Kotanidou Anastasia , Clavel-Chapelon Françoise , Weiderpass Elisabete , Johansson Mattias , Pawlita Michael , Scelo Ghislaine , Tommasino Massimo , Brennan Paul
Published: March 2023

PDF file - 55KB, Association between type-specific HPV antibodies and risk of lung cancer by seropositivity threshold.
Supplementary Figure Legends from Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence
Authors: Payne Ania W. , Pant Dhruv K. , Pan Tien-Chi , Chodosh Lewis A.
Published: March 2023

Figure legends corresponding to Supplementary Figures 1-5.
Supplemental Figures S1-S5, Tables S1-S2 from Preclinical Activity of Nanoliposomal Irinotecan Is Governed by Tumor Deposition and Intratumor Prodrug Conversion
Authors: Kalra Ashish V. , Kim Jaeyeon , Klinz Stephan G. , Paz Nancy , Cain Jason , Drummond Daryl C. , Nielsen Ulrik B. , Fitzgerald Jonathan B.
Published: March 2023

Supplemental Figures S1-S5, Tables S1-S2. This document includes supplemental figures and corresponding legends. Table S1. Differential equations for plasma PK and tumor deposition models. Figure S1. Pharmacokinetic profile of nal-IRI across various tissues. Figure S2. Precision of parameter estimates. Figure S3. Comparing the concentrations of free CPT-11 and total CPT-11 in plasma and tumors. Figure S4. Surrogates for tumor depostion and local activation of nal-IRI. Table S2. Concentrations of CPT-11, SN-38 and CES activity in the panel of xenograft models. Figure S5. In vitro activation of nal-IRI in U937 cell lines.
Supplementary Figure 2 from Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia
Authors: Schubbert Suzanne , Cardenas Anjelica , Chen Harrison , Garcia Consuelo , Guo Wei , Bradner James , Wu Hong
Published: March 2023

Cellular effects of rapamycin in T-ALL.
Table S1 from Synergy between the NAMPT Inhibitor GMX1777(8) and Pemetrexed in Non–Small Cell Lung Cancer Cells Is Mediated by PARP Activation and Enhanced NAD Consumption
Authors: Chan Manuel , Gravel Michel , Bramoullé Alexandre , Bridon Gaëlle , Avizonis Daina , Shore Gordon C. , Roulston Anne
Published: March 2023

Table S1. Potency of the combination of GMX and PTX in various cell lines.
Supplementary Figure 6 from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Authors: Ghosh Susmita , Varela Lidenys , Sood Akshay , Park Ben Ho , Lotan Tamara L.
Published: March 2023

PDF - 1821 KB, Inducible expression of v-SRC induces invasive behavior in MCF10A cells. (A) Constitutive SRC activity induces epithelial invasion in MCF10A acinar cultures.
Supplementary Figure 1 from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Authors: Ghosh Susmita , Varela Lidenys , Sood Akshay , Park Ben Ho , Lotan Tamara L.
Published: March 2023

PDF - 4796K, In vitro Cre induction is efficient and does not inhibit morphogenesis using the R26CreER system in mammary organoid cultures.
Supplementary Figures 1 - 6 from IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism
Authors: Grassian Alexandra R. , Parker Seth J. , Davidson Shawn M. , Divakaruni Ajit S. , Green Courtney R. , Zhang Xiamei , Slocum Kelly L. , Pu Minying , Lin Fallon , Vickers Chad , Joud-Caldwell Carol , Chung Franklin , Yin Hong , Handly Erika D. , Straub Christopher , Growney Joseph D. , Vander Heiden Matthew G. , Murphy Anne N. , Pagliarini Raymond , Metallo Christian M.
Published: March 2023

PDF file - 348KB, Figure S1: Isogenic IDH1 mutation compromises metabolic reprogramming under hypoxia. Figure S2: Simulated and measured uncorrected MIDs. Figure S3: Compromised Reductive TCA Metabolism is specific to cells with mutant IDH1. Figure S4: Cells with endogenous IDH1 and IDH2 mutations respond differently to mitochondrial stress. Figure S5: Inhibition of mutant IDH1 does not rescue reprogramming of TCA metabolism. Figure S6: Cells expressing mutant IDH1 are sensitive to pharmacological inhibition of mitochondrial oxidative metabolism.
Supplementary Table 1 from JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells
Authors: Kroon Paula , Berry Paul A. , Stower Michael J. , Rodrigues Greta , Mann Vincent M. , Simms Matthew , Bhasin Deepak , Chettiar Somsundaram , Li Chenglong , Li Pui-Kai , Maitland Norman J. , Collins Anne T.
Published: March 2023

PDF file, 8K, 3.mRNA expression of IL-6 (fold change) in prostatic primary cultures.
Data Supplement from miR-21 Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors
Authors: Gong Chang , Nie Yan , Qu Shaohua , Liao Jian-You , Cui Xiuying , Yao Herui , Zeng Yunjie , Su Fengxi , Song Erwei , Liu Qiang
Published: March 2023

Supplementary Table S1. Incidence and liver metastasis rate of Tumors from PTs cells in Nude Mice.
Supplementary Table 2 from MicroRNA100 Inhibits Self-Renewal of Breast Cancer Stem–like Cells and Breast Tumor Development
Authors: Deng Lu , Shang Li , Bai Shoumin , Chen Ji , He Xueyan , Martin-Trevino Rachel , Chen Shanshan , Li Xiao-yan , Meng Xiaojie , Yu Bin , Wang Xiaolin , Liu Yajing , McDermott Sean P. , Ariazi Alexa E. , Ginestier Christophe , Ibarra Ingrid , Ke Jia , Luther Tahra , Clouthier Shawn G. , Xu Liang , Shan Ge , Song Erwei , Yao Herui , Hannon Gregory J. , Weiss Stephen J. , Wicha Max S. , Liu Suling
Published: March 2023

Clinical stages and the percentage of ALDH1+ cells and mir-100+ cells of the 94 patients.
Supplementary Figure S2 from Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein
Authors: Koshikawa Naohiko , Hoshino Daisuke , Taniguchi Hiroaki , Minegishi Tomoko , Tomari Taizo , Nam Sung-Ouk , Aoki Mikiko , Sueta Takayuki , Nakagawa Takashi , Miyamoto Shingo , Nabeshima Kazuki , Weaver Alissa M. , Seiki Motoharu
Published: March 2023

Supplementary Figure S2. Schematic illustration of EphA2-mediated signals.
Supplementary Movie 2 from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: March 2023

Supplementary Movie 2. Final images where the computed aggregate outline and center were drawn in red. Time is indicated at the top left. Time origin was set at the end of the centrifugation step.
Supplementary Material from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: March 2023

Supplementary Material. Spherotrack.docx is a step-by-step procedure to use the MATLAB code used in this study. bwfinal.m, bwmcherry.m, bwtrans.m and spherotrack.m are four MATLAB code to be used as described.
Supplementary Figure S3 from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: March 2023

Supplementary Figure S3. Inhibition of myosin IIa activity increases the kinetics of cell aggregation. Down-regulation of myosin IIa by transfection of MYH9 siRNA increased the kinetics of cell aggregation in HCT116 cells (see Fig. 5). A, western blotting (left) and immunofluorescent staining with anti-myosin IIA antibodies (right) demonstrates that MYH9 siRNA transfection inhibits myosin IIA (Myo IIA) expression in HCT116 cells after 72 hours. B, the selective myosin II inhibitor blebbistatin had a similar effect on aggregation as had MYH9 siRNA, as shown in time-lapse images (left) and measurements of area variation (right).
Supplementary Figure S2 from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: March 2023

Supplementary Figure S2. E-cadherin expression in HCT116, MCF-7 and MDA-MB-231 cell lines. Bottom, E-cadherin fluorescence (E-Cadh). Top, merged images of E-cadherin fluorescence (green) and DAPI fluorescence (blue) staining of the nuclei. HCT116 cells were seeded on glass slides 3 days before immunofluorescent staining (Bar, 50 µm). MCF7 and MDA-MB-231 spheroids were fixed after 7 days in culture and immunofluorescent staining was performed on frozen sections (Bar, 100 µm).
Supplementary Table S6 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Table S6. Primers used in this study are listed.
Supplementary Table and Figure Legend from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: March 2023

Legend for Supplementary Figure S1 and Supplementary Tables S1-S5.
Supplementary Table S3 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: March 2023

The biomarker candidates previously reported in pancreatic cyst fluids.
Supplementary Table S2 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: March 2023

Sixty-two differentially expressed proteins (DEPs) selected for the further MRM-MS.
Supplementary Table S1 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: March 2023

Total identified cyst proteins using shotgun proteomics.
Supplementary Figure S2 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Figure S2. Copy number variations.
Supplementary Methods and References from Definition of Prostaglandin E2–EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth
Authors: Ma Xiaojun , Aoki Tomohiro , Tsuruyama Tatsuaki , Narumiya Shuh
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Figure S3 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Supplemental Figure S3. Syntheses and characterization of lead HDAC inhibitors.
Supplemental Figure S2 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Supplemental Figure S2. 17-DMAG enhanced the effect of Tubacin on inhibition of Hsp90(α/β)/p23 interactions.
Supplementary Table 1 from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

List of imputation results at the 6p22.3 region.
Supplementary Figure 8 from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

Cell viability assays for neuroblastoma cell lines stably depleted of CASC15-S.
Supplementary Table S5 from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: March 2023

Supplementary Table S5. Bliss analysis summary of drug combinations with dasatinib in DDR2-mutant squamous cell carcinoma cells.
Supplementary Figure 2 from PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia
Authors: McElwee John L. , Mohanan Sunish , Horibata Sachi , Sams Kelly L. , Anguish Lynne J. , McLean Dalton , Cvitaš Iva , Wakshlag Joseph J. , Coonrod Scott A.
Published: March 2023

Supplementary Figure 2: Control immunohistochemical analysis (Rabbit IgG) of epidermis in transgenic mice (MMTV-FP2+)
Supplementary Fig 4 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: March 2023

CCT251455-resistant HCT116 clones.
Supplementary Figure Legend and Reference from NKX3.1 Suppresses TMPRSS2–ERG Gene Rearrangement and Mediates Repair of Androgen Receptor–Induced DNA Damage
Authors: Bowen Cai , Zheng Tian , Gelmann Edward P.
Published: March 2023

Supplementary Figure Legend and Reference. Legend for Supplementary Figures S1-S7. Also includes Supplementary Reference.
Supplementary Methods from Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay–Independent Manner
Authors: Kratochvill Franz , Gratz Nina , Qualls Joseph E. , Van De Velde Lee-Ann , Chi Hongbo , Kovarik Pavel , Murray Peter J.
Published: March 2023

Description of additional methods and procedures used in the study.
Supplementary Figure S5 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: March 2023

Supplementary Figure S5. PDGFRÃƒ? pathway inhibition in foretinib treated Daoy and D425 medulloblastoma cells
Supplementary Figure S3 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: March 2023

Supplementary Figure S3. Clinicopathological correlations of SHH medulloblastomas according to p-cMET status
Supplemental Figures from Effective Cancer Vaccine Platform Based on Attenuated Salmonella and a Type III Secretion System
Authors: Xu Xin , Hegazy Wael A.H. , Guo Linjie , Gao Xiuhua , Courtney Amy N. , Kurbanov Suhrab , Liu Daofeng , Tian Gengwen , Manuel Edwin R. , Diamond Don J. , Hensel Michael , Metelitsa Leonid S.
Published: March 2023

Supplemental Figures. S1: Chemokine/Cytokine Quantification in Serum and in Tumor Microenvironment. S2: Blocking of CXCR3 suppresses the infiltration of CD8 T cell. S3: Administration of 7DW8-5 results in activation of NKT cells, NK cells, and DC in mouse spleen.
Supplemental Methods, Figures 1 - 8, Tables 1 - 2 from RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway–Dependent Tumors
Authors: Zhao Xuesong , Ponomaryov Tatyana , Ornell Kimberly J. , Zhou Pengcheng , Dabral Sukriti K. , Pak Ekaterina , Li Wei , Atwood Scott X. , Whitson Ramon J. , Chang Anne Lynn S. , Li Jiang , Oro Anthony E. , Chan Jennifer A. , Kelleher Joseph F. , Segal Rosalind A.
Published: March 2023

Figure S1. Growth and survival of SMB cells depends on Shh signaling. Figure S2. SMB cell lines are a faithful model to study resistance to Smo inhibitors. Table S1. List of candidate genes with mutations used in the study. Figure S3. RAS signaling confers resistance to Smo inhibitor LDE225. Figure S4. FGF/RAS signaling abrogates dependence on Shh signaling. Figure S5. FGF/RAS-driven resistance to Smo inhibition is reversible and can be treated with MEK inhibitors. Figure S6. MEK inhibitors have therapeutic potential for HRAS SMB cells. Figure S7. Morphology of SMB(HRAS) cells differs from SMB parental cells. Figure S8. Immunohistochemistry of SFRP1, pERK and FGF in primary and metastatic samples from human Shh-subtype medulloblastoma patients. Table S2. Clinical diagnosis for human patient samples shown in Figure 5.