bluuebunny/crossref_metadata_2025 huggingface dataset:
THE POPULATION AND DISTRIBUTION OF AGARWOOD PRODUCING TREE (AQUILARIA MALACCENSIS) IN RIAU PROVINCE
Authors: Yulizah Yulizah , Rahajoe Joeni Setijo , Fefirenta Agusdin Dharma , Nugroho Agung Adi
Published: June 2022

YULIZAH, RAHAJOE, J. S., FEFIRENTA, A. D. & NUGROHO, A. D. 2022. The population and distribution of agarwood producing tree (Aquilaria malaccensis) in Riau Province. Reinwardtia 21(1): 1–11. — Riau Province is one of the largest agarwood producers and supplier of Aquilaria malaccensis species in Indonesia, based on the data of trade quota that was issued by the Ministry of Environment and Forestry in 2018. The quota data will be used for monitoring the sustainability of the population agarwood producing trees in the wild. The aimed of the study were to determine the natural population distribution and habitat preference of wild agarwood-producing trees in Riau Province. The agarwood population census carried out by making random plots in the study sites, soil moisture, soil pH, temperature and the humidity recorded, and the macronutrients data also used to support the habitat preferences for the agarwood producing taxa tree. Seven locations of agarwood producing trees were selected for the study sites including Taman Hutan Raya (TAHURA: Forest Park Garden) Sultan Syarif Hasyim (SSH), three community forests in Siak Sri Indapura District (Gosib, Perincit and Dosan), and three community forests in Bengkalis District (Langkat, Pangkalan Jambi, and Duri Km 13). The density of agarwood producing trees in TAHURA SSH recorded for about 38 plants ha-1, with an average diameter distribution was 15 cm, and the tree height was 9.51 m. Perincit data showed the highest density, with 8.13 plants ha-1  with an average distribution of tree diameters was recorded for 20.8 cm and the tree height was 9.11 m. While the lowest tree density was recorded for 0.58 plant ha-1 in Gosib, the average diameter and tree height were recorded for 40.15 cm and 14.70 m, respectively. Environmental parameters and soil chemistry were the main factors to support the tree growth of agarwood. The result was necessary for the conservation program of A. Malaccensis, and support data for providing potential seeds source and seedling. The nutrient content preference from the finding of this research will also be used as the necessary information of the needs of nutrient content in the natural habitat of agarwood plantations.
Radiation Dose Reduction and Surgical Efficiency Improvement in Endoscopic Transforaminal Lumbar Interbody Fusion Assisted by Intraoperative O-arm Navigation: A Retrospective Observational Study
Authors: Gong Junfeng , Huang Xinle , Luo Liwen , Liu Huan , Wu Hao , Tan Ying , Li Changqing , Tang Yu , Zhou Yue
Published: June 2022

Objective: Endoscopic transforaminal lumbar interbody fusion (Endo-TLIF) has gained increasing popularity among spine surgeons. However, with the use of fluoroscopy, intraoperative radiation exposure remains a major concern. Here, we aim to introduce Endo-TLIF assisted by O-arm-based navigation and compare the results between O-arm navigation and fluoroscopy groups.Methods: Sixty-four patients were retrospectively analyzed from May 2019 to September 2020; the nonnavigation group comprised 34 patients, and the navigation group comprised 30 patients. Data on radiation dose, blood loss, postoperative drains, surgery time, complications, and length of hospital stay (LOS) were collected. Clinical outcomes were evaluated from postoperative data such as fusion rate, Oswestry Disability Index (ODI), and visual analogue scale (VAS). Radiation dose and surgery time were selected as primary outcomes; the others were second outcomes.Results: All patients were followed up for at least 12 months. No significant differences were detected in intraoperative hemorrhage, postoperative drains, hospital LOS, or complications between the 2 groups. The radiation dose was significantly lower in the navigation group compared with the nonnavigation group. The time of cannula placement and pedicle screw fixation was significantly reduced in the navigation group. No significant differences were detected between the clinical outcomes in the 2 groups (VAS and ODI scores).Conclusion: The present study demonstrates that O-arm-assisted Endo-TLIF is efficient and safe. Compared with fluoroscopy, O-arm navigation could reduce the radiation exposure and surgical time in Endo-TLIF surgery, with similar clinical outcomes. However, the higher doses exposed to patients remains a negative effect of this technology.
The Role of Alginate Hydrogels as a Potential Treatment Modality for Spinal Cord Injury: A Comprehensive Review of the Literature
Authors: Jarrah Ryan , Sammak Sally El , Onyedimma Chiduziem , Ghaith Abdul Karim , Moinuddin F.M. , Bhandarkar Archis R. , Siddiqui Ahad , Madigan Nicolas , Bydon Mohamad
Published: June 2022

Objective: To comprehensively characterize the utilization of alginate hydrogels as an alternative treatment modality for spinal cord injury (SCI).Methods: An extensive review of the published literature on studies using alginate hydrogels to treat SCI was performed. The review of the literature was performed using electronic databases such as PubMed, EMBASE, and OVID MEDLINE electronic databases. The keywords used were “alginate,” “spinal cord injury,” “biomaterial,” and “hydrogel.”Results: In the literature, we identified a total of 555 rat models that were treated with alginate scaffolds for regenerative biomarkers. Alginate hydrogels were found to be efficient and promising substrates for tissue engineering, drug delivery, neural regeneration, and cellbased therapies for SCI repair. With its ability to act as a pro-regenerative and antidegenerative agent, the alginate hydrogel has the potential to improve clinical outcomes.Conclusion: The emerging developments of alginate hydrogels as treatment modalities may support current and future tissue regenerative strategies for SCI.
Twitter Bot using { rvest } , { rtweet } and a GitHub Action
Authors: Nurussadad Abdul Aziz , Rizki Akbar
Published: June 2022

The National Strategic Food Price Information Center (PIHPS) was established by the Government of Indonesia and Bank Indonesia,with the aim of providing access to the latest food price information daily for the public and at the same time supporting the formulation of inflation control policies. Officially, this information can be accessed through the website (https://hargapangan.id/) and applications on Android and iOS. There has been a voluntary effort to further disseminate this information via twitter @hargapan***, but this was being done manually and was active only temporarily. panganBot retrieves data from http://hargapangan.id using {rvest}, processes it, and publishes it to the Twitter account @panganBot using {rtweet}. This is done automatically via GitHub Action.
Hand detection application based on QRD RLS lattice algorithm and its implementation on Xilinx Zynq Ultrascale+
Authors: Likhonina Raissa , Uglickich Evženie
Published: June 2022

The present paper describes hand detection application implemented on Xilinx Zynq Ultrascale+ device, comprising multi-core processor ARM Cortex A53 and FPGA programmable logic. It uses ultrasound data and is based on adaptive QRD RLS lattice algorithm extended with hypothesis testing. The algorithm chooses between two use-cases: (1) there is a hand in front of the device vs (2) there is no hand in front of the device. For these purposes a new structure of the identification models was designed. The model presenting use-case (1) is a regression model, which has the order sufficient to cover all incoming data. The model responsible for use-case (2) is a regression model, which has a smaller order than the model (1) and a certain time delay, covering the maximal distance where the hand can possibly appear. The offered concept was successfully verified using real ultrasound data in MATLAB optimized for parallel processing and implemented in parallel on four cores of ARM Cortex A53 processor. It was proved that computational time of the algorithm is sufficient for applications requiring real-time processing.
More than ponds amid skyscrapers: Urban fisheries as multiscalar human–natural systems
Authors: Carlson Andrew K. , Boonstra Wiebren J. , Joosse Sofie , Rubenstein Daniel I. , Levin Simon A.
Published: June 2022

Although social-ecological fisheries research is growing, comparatively little attention is paid to fisheries in urban environments. We aim to address this imbalance, because as cities expand worldwide, we expect urban fisheries to become more widespread and important in providing food/nutrition security, recreation, community well-being, and other benefits to fisheries stakeholders and urban dwellers across spatiotemporal scales. This paper contains a first analysis of the economic and sociocultural provisions, trade-offs, and dilemmas associated with urban fisheries to yield insights for sustainable management and planning of urban blue space. To address these objectives, we use the metacoupling framework, a method for assessing human–nature interactions within and across adjacent and distant fisheries systems. We use examples from multiple countries and data from the United States to illustrate how urban fisheries encompass flows of people, money, and information across multiple spatiotemporal scales and provide nutritional, recreational, social, and cultural benefits to fisheries stakeholders. Throughout the world, urban fisheries are influenced by wide-ranging human needs (e.g. food provisioning, recreation, aquatic resource education) that generate social-ecological effects within and beyond cities. Our analysis yields insights for developing holistic, metacoupling-informed management approaches that address the diverse social-ecological objectives and trade-offs involved in sustainable development of urban fisheries.
Evaluation of Physicians' Perception of Patient Safety Incidents Including Disclosure Utilizing Hypothetical Clinical Vignettes
Authors: Kim Juyoung , Pyo Jee-Hee , Choi Eun-Young , Lee Won , Jang Seung-Gyeong , Ock Min-Su , Lee Sang-Il
Published: June 2022

Purpose:We investigated physicians' responses to a series of clinical vignettes consisting of patient safety incidents, with and without disclosure of patient safety incidents (DPSI).Methods: An anonymous survey was conducted to investigate physicians’ responses to the DPSI via online communities of physicians, and additional participants were recruited using a snowballing sampling method. We evaluated physicians’ responses to the DPSI using eight hypothetical scenarios (HS) from the following perspectives: thoughts regarding medical errors, revisiting the physician, recommendation, lawsuit, criminal prosecution, trust score, and compensation amounts. We used the chi-square test to evaluate the overall differences in response rates among the scenarios. Statistical analyses were performed using the Student's t-test to compare the trust scores and compensation amounts.Results: A total of 910 physicians participated in this survey. An overall comparison of trust scores among HS showed that HS 1 (unclear medical errors, minor harm, and DPSI) had the highest trust score. In contrast, in the opposite scenario, HS 8 (clear medical errors, major harm, and DPSI not conducted) received the lowest scores. Cases with minor harm to patients (HS 1, 2, 5, and 6) showed lower compensation amounts than the others (HS 3, 4, 7, and 8). Physicians were more likely to think of situations with DPSI as not having medical errors (53.1% vs. 55.2%). In addition, the scenarios with DPSI were evaluated favorably in terms of intention to revisit, recommend, suit, and engage in criminal proceedings. Physicians showed higher trust scores (6.2 vs 5.4) and gave lower compensation amounts ($27.7 million vs $28.1 million), although there was no significant difference in terms of compensation amounts to the physician conducting DPSI.Conclusion: Our study showed overall positive perceptions regarding DPSI among Korean physicians.
Los Técnicos en el regreso de Perón: el caso del Consejo de Planificación (1970-1973)
Authors: Denaday Juan Pedro
Published: June 2022

La historiografía de los años sesenta y setenta en la Argentina ha recorrido ampliamente el fenómeno de la violencia política. Este artículo trata sobre un asunto colindante: el de la conformación de equipos técnicos peronistas a partir del año 1970. Se aborda específicamente el caso del Consejo de Planificación del Movimiento Nacional Justicialista (CPMNJ), el más temprano y oficial entre ellos. Se examina el vínculo mantenido entre el secretario general del CPMNJ, Leopoldo Frenkel, y el líder exiliado Juan Domingo Perón; se analizan los avatares de este grupo técnico en el marco del juego político local del justicialismo; y se reconstruye su membresía y sus áreas de intervención política y profesional. A través de la reconstrucción histórica de las redes de técnicos reunidos en torno a este think tank, el trabajo destaca la presencia de prácticas políticas moderadas e institucionalistas entre los actores del peronismo de los setenta.
Contactos, títulos y apariencias. Inserciones laborales y experiencia de la desigualdad en jóvenes
Authors: Gonzaléz Federico Martín , Bostal María Cecilia
Published: June 2022

El presente artículo propone analizar los procesos de inserción laboral y la configuración de experiencias desiguales en el mundo del trabajo en jóvenes egresados del nivel secundario en la ciudad de La Plata, durante el período 2013-2019. Desde una perspectiva    metodológica cualitativa analizamos setenta y ocho entrevistas en profundidad a varones y mujeres de 18 a 24 años de edad y registros de observaciones participantes. A partir de allí recuperamos y analizamos tres dimensiones que intervienen en las inserciones laborales (el lugar de las redes sociales, la finalización de la escuela secundaria y la configuración de clasificaciones morales e interaccionales), concluyendo en la importancia de un abordaje multidimensional de la desigualdad social en el análisis de las primeras experiencias laborales de los jóvenes.
Proyecto correccional femenino y descolonialidad. Nuevas lecturas al proyecto de dominación en Córdoba, 1892-1912
Authors: Maritano Ornella
Published: June 2022

El siguiente artículo presenta una revisión del proyecto correccional femenino llevado adelante por la Congregación del Buen Pastor, en Córdoba, a fines del siglo XIX y principios del XX a partir de los aportes del feminismo descolonial. Poniendo especial atención al universo social que habitó la Cárcel Correccional de Mujeres y Asilo de Menores del Buen Pastor y a las estrategias de corrección como la formación laboral impartida en la institución, se establecen relaciones que permiten identificar un arreglo colonial de género que pretende asegurar la dominación y garantizar la hegemonía. A partir de la figura de la colocación y el entramado de actores que ésta supone se identifica la operatividad de las ficciones de raza, género y clase en la sociedad cordobesa.
Entrevista con Juan Carlos Torre a propósito de su libro Diario de una temporada en el quinto piso
Authors: Quiroga Hugo , Comba Daniel
Published: June 2022

Juan Carlos Torre
Family Resilience of The Aspiring Middleclass Facing Covid-19: A Mixed Method Study
Authors: Murty Ade Iva , Rizkyanti Charyna Ayu , Ramadhania Andita Putri , Anjani Safira Binar , Airlia Dienia
Published: June 2022

The study aimed to develop an explanation of family resilience processes among the aspiring middle-class in Jakarta Greater Area or JABODETABEK during the Covid-19 pandemic. The aspiring middle-class refers to a social class that is not yet a middle-class but will eventually achieve the middle-class status. How do the aspiring middle-class families bounce back from the crisis and become strong and healthy families and it could contribute to comprehending the commonly described social unit that is labeled for its vulnerabilities to any major shocks. This is a mixed-method study with a quantitative approach and enriched with qualitative data. The results showed that most participants come from an aspiring middle-class with a high value on the Family Resilience Assessment Scale (Sixbey, 2005). Furthermore, themes found are family belief system, family organizational pattern, problem-solving communication, health protocol adherence, and family economic condition. The study concluded that multidimensional factors enable the development process of family resilience. Governmental programs for developing family well-being and resilience can take advantage of this research, especially about the multidimensional factors that will be a noteworthy entry point for the intervention of family program enhancement. Abstrak. Studi ini bertujuan untuk menjelaskan proses terbentuknya ketangguhan keluarga dari kelas menengah aspiratif (the aspiring middleclass) di Jabodetabek, pada masa berjangkitnya wabah Covid-19. Studi ini bermanfaat untuk menjelaskan bagaimana keluarga-keluarga yang sedang menuju kelas menengah ini menghadapi krisis dan kemudian bangkit kembali sebagai sebuah keluarga yang sehat fisik dan mental. Metode penelitian studi ini adalah metode campuran, dengan penekanan utama pada metode kuantitatif dan pengayaan data melalui pendekatan penelitian kualitatif. Alat ukur yang dipakai bersumber dari pemikiran Walsh (2003), yakni alat ukur Sixbey (2005) The Family Resilience Assessment Scale (Skala Ketangguhan Keluarga). Hasil penelitian dengan metode kuantitatif memperlihatkan sebagian besar responden berasal dari keluarga kelas menengah aspiratif (the aspiring middleclass) dengan level of resilience atau tingkat ketangguhan tinggi. Tema-tema yang muncul dari data kualitatif adalah sistem keyakinan keluarga, pola-pola pengorganisasian keluarga, komunikasi berorientasi pemecahan masalah, kepatuhan terhadap protokol kesehatan dan kondisi perekonomian keluarga. Dapat disimpulkan, studi ini memperlihatkan bagaimana proses ketangguhan keluarga terbentuk melalui pengaruh variabel-variabel mutidimensional. Program-program pemerintah untuk kesejahteraan dan ketangguhan keluarga dapat memanfaatkan hasil penelitian ini, khususnya dengan memanfaatkan temuan-temuan mengenai faktor-faktor yang mesti mendapatkan intervensi meningkatkan ketangguhan keluarga.
Dealing the Crisis Together: The Meaning of Family Support for Employees Infected by Covid-19
Authors: Kristina Destri Ayu , Indraswari Candra
Published: June 2022

During the COVID-19 pandemic, family support is needed especially for those who are infected by Covid-19. This study aimed to comprehend the meaning of family support for employees infected with COVID-19. The study used qualitative method with a phenomenological approach. Online and offline interviews were conducted to collect the data. This research had three main informants who work at Company X and each informant was followed by one significant other. The result showed that although the support of each family was different, the meanings that appeared in the three informants had similarities. The three informants interpreted family support as a motivation to come back home and to be healthy again. In addition, all informants interpreted family support as a stress reliever during isolation. In all informant’s views, their family had provided support for them, although in different ways for each informant. Therefore, the main factor influencing the recovery of the informants was family support and only family who always stay and accept their situation. In the end, family support is also interpreted as a spirit when informants face discrimination in their workplace. From the experience of all informants, it is known that family support makes a huge contribution to the recovery process when informants were infected by COVID-19.Abstrak. Saat pandemi seperti ini dukungan keluarga sangat dibutuhkan, terlebih bagi mereka yang sedang terinfeksi COVID-19. Penelitian ini bertujuan untuk memahami dan mengetahui makna dari dukungan keluarga bagi karyawan yang terinfeksi virus COVID-19. Informan dalam penelitian kali ini adalah tiga karyawan yang positif terpapar COVID-19. Penelitian menggunakan metode kualitatif dengan pendekatan fenomenologi dengan menggunakan teknik wawancara secara online dan offline. Penelitian ini memiliki tiga informan utama yang bekerja di Perusahaan X dan masing-masing informan diikuti oleh significant other. Hasil menunjukkan bahwa meskipun dalam bentuk perlakuan setiap keluarga berbeda, namun makna yang muncul pada ketiga informan memiliki kesamaan. Ketiga informan memaknai dukungan keluarga sebagai motivasi untuk kembali pulang dengan sehat kembali. Selain itu, informan memaknai dukungan keluarga sebagai penghilang stress saat isolasi. Bagi semua informan, keluarga akan selalu memberikan dukungan kepada mereka meskipun dengan cara yang berbeda-beda untuk setiap informan. Oleh karenanya, faktor utama yang mempengaruhi kesembuhan informan adalah dukungan keluarga. Hanya keluarga yang selalu bertahan dan menerima keadaannya. Pada akhirnya, dukungan keluarga juga dimaknai sebagai semangat menghadapi diskriminasi yang diterima informan di tempat kerja. Dari pengalaman seluruh informan diketahui bahwa dukungan keluarga memberikan kontribusi yang sangat besar dalam menjalani proses pemulihan ketika orang terinfeksi covid-19.
Causas del desempleo en Colombia en el siglo XXI. Evidencia a partir de un modelo VAR-X cointegrado
Authors: Espinosa Acuña Oscar Andrés , Vaca González Paola Andrea
Published: June 2022

Este artículo presenta los resultados de una investigación acerca de los posibles determinantes del desempleo en Colombia en el siglo XXI, mediante un modelo VAR-X cointegrado. El análisis de cointegración evidencia estadísticamente una relación de largo plazo entre las variables términos de intercambio, ventas reales, productividad laboral, empleo, salarios reales y desempleo. Al estimar el modelo y desarrollar el análisis de impulso respuesta, se concluye que las ventas reales son un factor importante para el desempleo en el corto plazo, como la productividad lo es en gran medida para el mediano y largo plazo. Este análisis se confirma con los resultados arrojados por la descomposición de varianza.
Ciclo intergeneracional de la violencia doméstica contra la mujer: análisis para las regiones de Colombia
Authors: Cárdenas Varón Gina , Polo Otero José Luis
Published: June 2022

El objetivo de esta investigación fue identificar y analizar la existencia del ciclo intergeneracional de la violencia doméstica contra la mujer, perpetrada por su pareja. Este artículo aporta a la literatura nuevas perspectivas de políticas orientadas a mitigar los efectos generados por este tipo de violencia. A partir de la Encuesta Nacional de Demografía y Salud (2010), se utilizaron modelos probit con errores estándar robustos, cuyos resultados indican que las conductas violentas se transmiten entre padres e hijos, así como también, que existen diferencias regionales en la probabilidad de sufrir violencia doméstica.
In Silico Study of Chemical Compounds in Plantago major L. as Anti-Androgen
Authors: Baihaqi Achmad Al , Isman Hasna Siti Munifah , Fauziyyah Ganis Fitria , Hutabarat Rismauli Ruth Natasari , Hartono Adi , Megantara Sandra
Published: June 2022

Prostate cancer is the most common type of cancer diagnosed in men worldwide and the second leading cause of death after lung cancer. Testosterone and dihydrotestosterone (DHT) have been known to play an essential role in prostate cancer. Androgen receptor (AR) binding to the ligand allows homodimerization and translocation to the nucleus, which acts as a transcription factor for androgen-responsive genes such as PSA (Prostate-specific antigen). Although many anti-androgens have been established, including Bicalutamide, Flutamide, and Abiraterone, the problem of non-specific cytotoxicity effects and cancer recurrence due to potential drug resistance remains a significant obstacle to establishing effective therapy. Plantago major L. is one of the plants that can choose anticancer therapy because, based on reports, it has anticancer activity through DNA damage in cancer cells. This study focused on the search for the potential phytochemical activity of Plantago major L. as an anti-androgen, non-cytotoxic, and had significant AR inhibitory activity. This study uses Lipinski prediction (RO5), ADMET prediction, and a structure-based approach with molecular docking techniques using the PDB ID 2AM9 receptor structure and 13 compounds from Plantago major L. as test ligands compared to known AR antagonists. From the research results, Hispidulin has the highest potential as an anti-androgen with binding energy (-9.43 kcal/mol) that is closest to natural ligands and is smaller than Flutamide as a comparison drug. This anti-androgen activity was hypothesized from the similarity of hydrogen bonds with amino acid residues 705-Asn and 711-Gln as key AR residues present in Hispidulin.Keywords: Prostate cancer, Androgen Receptor, Plantago major L., ADMET, In Silico.
Protein-protein Docking Studies of Estrogen Receptor Alpha and TRIM56 Interaction for Breast Cancer Drug Screening
Authors: Dhiani Binar Asrining , Nurulita Nunuk Aries , Fitriyani Fitriyani
Published: June 2022

Breast cancer is the highest mortality cause in women with cancer. Protein-protein docking for target-based screening is an effective approach in breast cancer drug discovery via estrogen receptor (ER) signaling. TRIM56, an E3 ubiquitin protein ligase, can bind to and stabilize ER alpha. Thus, drug screening that can inhibit or weaken the interaction between ER alpha and TRIM56 is promising to obtain novel yet specific breast cancer drugs. In this study, we performed protein-protein docking studies for ER alpha and TRIM56 interaction and virtual screening for FDA-approved drugs from the ZINC database against ER alpha and TRIM56 complex protein model structure. We utilized Cluspro 2.0, PyRx 0.8, and Pymol 2.4.1 to conduct protein-protein docking, virtual screening, and model structure visualization. PIP and PLIP software were also applied to analyze the amino acid residue between proteins or protein-ligands. Based on the protein-protein docking, ER alpha and TRIM56 established interaction. Utilizing this complex protein as a macromolecule in the virtual screen of 1071 molecules of FDA-approved drugs, we obtain the top five lowest binding energy molecules i.e., dutasteride, dihydroergotamine, nilotinib, ergotamine, and bromocriptine. In addition, the energy binding affinity between ER alpha-dutasteride complex with TRIM56 was weakened in the presence of dutasteride. In conclusion, protein-protein docking between ER alpha-TRIM56 was able to select FDA-approved drugs that could bind to the complex, and dutasteride binding to ER alpha-TRIM56 complex weakened the interaction.Keywords: protein-protein docking, estrogen receptor alpha, TRIM56, breast cancer, ubiquitin.
Dietary Curcuma, a Powerful Epigenome Modulator in Breast Cancer: an In Silico Study
Authors: Elbasyouni Amel , Saadi Leila , Baha AbdelKarim
Published: June 2022

The inhibition of DNA methyltransferase-1 enzyme can strongly decrease the capacity of cells to enhance the tumour-genesis process. Members of the Estrogen-Related Receptors family regulate several elements of cellular metabolism. These are orphan nuclear receptors that regulate a wide range of functional gene networks involved in breast carcinogenesis and the regulation of associated methionine and folate cycles, providing a proven direct relationship to DNA methylation as a result. Moreover, dietary phytochemicals, such as Curcumin, can involve epigenetic modification, which may decrease the development of many types of cancer, especially breast cancer in women. We conducted this study to investigate the effect of Curcuma (PubChem ID: 969516) on the epigenetic modification and inhibition of the DNA methyltransferase-1 (PDB ID: 3PTA) activity and Estrogen-Related Receptors (PDB ID: 1XB7) using Molecular docking approach and computational tools that may inform whether the Curcuma could provide this protective anticancer effect or not. Interestingly, the DNA methyltrasferase1-Curcumin and Estrogen-Related Receptors-Curcumin complexes display a docking score of -6.9 and -7.1 kcal/mol, respectively. Furthermore, Curcumin displays hydrogen, Pi-Cation, Pi-Anion and Van der Waals bonds with active site residues of the targeted molecules. By targeting DNA methylation via the combined inhibition of estrogen-related receptors and DNMT1, our research opens up a new therapeutic path for breast cancer treatment.Keywords: curcumin, breast cancer, epigenetic, molecular docking, treatment.
Elektronische Laborbücher in der Praxis: Folgen und Nutzen digitaler Forschungsdokumentation
Authors: Wetzel Christiane , Frenzel Ina , Schirmer Daniela , Pohlenz Philipp
Published: June 2022

Electronic laboratory notebooks (ELN) support transparent documentation of research processes, facilitate project-based team science and scientific exchange with cooperation partners. To foster transparency, cooperation, and knowledge transfer, academic research institutions increasingly support the use of ELN. Using the example of the institutional implementation of ELN at Charité – Universitätsmedizin Berlin, this article reflects on the social innovation potential of such a project. Based on the observation that researchers need to adapt routines in order to use ELN effectively and in line with institutional goals, this article emphasizes the social character of digital research documentation and the need to create awareness of this social character at all organizational levels. Furthermore, the development of social practices must be integrated early in higher education.
Fen Bilgisi Öğretmen Adaylarının Mesleki Performanslarına Yönelik Öz-Değerlendirmelerinin İncelenmesi
Authors: CENGİZ CANAN , ALKAN ŞENEM
Published: June 2022

Öz değerlendirme, öğrenenlerin öğretim sürecinde gerçekleştirdikleri çalışmaları ve sonucunda ulaştıkları öğrenme çıktılarını dikkate alarak kendilerini değerlendirmeleridir. Öğrenenlerin çalışmalarının veya performanslarının kalitesine yönelik düşüncelerini içeren öz-değerlendirme, biçimlendirici değerlendirmenin önemli bir bileşenidir. Bu çalışmada fen bilgisi öğretmen adaylarının öğretmenlik uygulaması süresince hazırladıkları yansıtıcı günlüklerin incelenmesi ve öğretmen adaylarının hangi konularda öz değerlendirme yaptıklarının belirlenmesi amaçlanmıştır. Bu çalışma, fenomenografik yöntem çerçevesinde yürütülmüştür. Çalışma Doğu Karadeniz’de yer alan bir eğitim fakültesinde öğrenim gören sekiz dördüncü sınıf fen bilgisi öğretmen adayı ile gerçekleştirilmiştir. Veri toplama aracını öğretmenlik uygulaması süresince öğretmen adaylarının hazırladıkları yansıtıcı günlükler oluşturmaktadır. Yansıtıcı günlüklerden elde edilen veriler içerik analizine tabi tutulmuştur. Öğretmen adaylarının büyük çoğunluğu konu ile ilgili temel ilke ve kavramlara hakim olduklarını ve uygulamalarında öğretim teknolojilerinden yeterli seviyede faydalanabildiklerini düşündüklerini belirtmişlerdir. Öğretmen adaylarının çoğu öğrenci sorularına yeterli ve uygun cevap verme konusunda ise yetersiz olduklarını, kesinti ve engellemelere karşı uygun önlem alma konusunda yetersiz olduklarını ve zamanı verimli kullanamadıklarını düşündüklerini belirtmişlerdir. Öğretmen adaylarının günlüklerinde dikkati çeken bir diğer husus ise günlüklerde konu ile alanın diğer konularını ilişkilendirebilme, öğrenme ortamının güvenliğini sağlayabilme, öğretimi bireysel farklılıklara göre sürdürebilme, demokratik bir öğrenme ortamı sağlayabilme, sözel dili ve beden dilini etkili biçimde kullanabilme konularına nadiren değinmiş olmalarıdır.
Anahtar Kelimeler: Öz değerlendirme, fen bilgisi öğretmen adayı, öğretmenlik uygulaması, yansıtıcı günlük
Kajian Kritis Komunikasi Krisis: Belajar dari Kerumitan Komunikasi Pemerintah Menghadapi Pandemi Covid-19
Authors: Wijayanto W , Martini Rina , Elsitra Gita N.
Published: June 2022

Dalam berbagai literatur komunikasi, telah banyak penulis yang membahas model komunikasi krisis yang ideal, namun belum banyak yang mengulas bagaimana ciri-ciri praktik komunikasi krisis yang buruk. Dengan menjadikan teori komunikasi Reynolds dan W. Seeger (2005) sebagai model, tulisan ini menganalisa praktik buruk komunikasi krisis yang dilakukan oleh pemerintah Indonesia menjelang kemunculan pandemi Covid-19 di Indonesia.  Dengan melakukan analisis isi media arus utama yang berisi pernyataan aparat pemerintah Indonesia, penulis menemukan ciri-ciri komunikasi krisis yang buruk itu, antara lain: Kurang responsif dalam mengantisipasi kemungkinan terjadinya wabah; Kurang transparansi dan akurasi data terbaru perkembangan pandemi; Inkonsistensi dan ketidakjelasan pesan di saat krisis memuncak; Kurang empati terhadap korban. Temuan tersebut menjadi esensial mengingat masa krisis bukan hanya terkait dengan Covid-19 saja, tetapi juga mengacu pada berbagai potensi krisis yang akan dihadapi Indonesia ke depannya.
Women’s News Coverage in Local Mass Media: A Case of Regional Head Election 2018
Authors: Sweinstani Mouliza K.D
Published: June 2022

The mass media can play a crucial role in election campaigns because it can influence people's points of view of a candidate, including how they responded to women candidates. This paper aims to analyze how the local media portrayed women candidates in the Local Executive Election (Pilkada) 2018 and the factors that drive it. Unlike most previous studies, which focused on women in legislative candidacy and analyzed the national mass media, this study focuses on women's candidacy in the local executive election by observing the local mass media. The author believes that the differences in the electoral system between the legislative election and the local executive one and the differences of the media scop will produce different findings. Using the explanatory sequential mixed method, the author combined the quantitative method followed up with the qualitative one to interpret this study's data. The author took a sample of 140 pieces of news from local mass media during March-23 June 2018, which was chosen by a non-probability sampling method with a quota technique. This study did not reveal any biased coverage toward women candidates due to four factors: the type of election that women participate in; the social-political capital of women candidates; the condition that women's active political participation is not a novelty; and the alignment of media to the more extensive political agenda. Therefore, it can be concluded that the neutrality of the media does not necessarily cause unbiased coverage, yet by the logic of the media, which makes the media are not passive conduits.
Uwarunkowania polskiej polityki gospodarczej po roku 2022
Authors: Banaszyk Piotr , Gorynia Marian
Published: June 2022

W artykule skupiono się na wskazaniu pożądanych kierunków polityki gospodarczej w Polsce na tle jej potencjału i aktualnych uwarunkowań. Założono, że stan polskiej gospodarki jest zdeterminowany współoddziaływaniem procesów transformacji, globalizacji i integracji europejskiej. Ostatnie chronologicznie determinanty tego stanu to kryzys wywołany pandemią COVOD-19 oraz agresja wojenna Rosji na Ukrainę. Wydarzenia te stworzyły zagrożenie stagflacją. Rosnące znaczenie Chin i wojna handlowa tego państwa z USA wraz z rosyjską agresją kruszą dotychczasowy międzynarodowy ład ekonomiczny. Procesy te zmieniają sytuację i perspektywy polskiej gospodarki, której sternicy powinni na nowo zdefiniować jej miejsce w nowym międzynarodowym ładzie gospodarczym, stopniowo wyłaniającym się pod wpływem tych wszystkich okoliczności. Niewiadomą jest finalny obraz następnej rzeczywistości gospodarczej. Jednak warto już teraz dążyć do włączenia polskich przedsiębiorstw w europejskie i światowe łańcuchy dostaw dzięki modernizacji technologicznej ich działalności. W obszarze polityki fiskalnej zamiast konkurować coraz niższymi stawkami i obciążeniami podatkowymi warto rozbudowywać infrastrukturę i instytucje publiczne. W odniesieniu do polityki monetarnej z powodu nieuchronnego wzrostu ryzyka ekonomicznego inwestycji zagranicznych w Polsce warto przyjąć euro i dzięki temu stworzyć bezpieczną perspektywę rozwoju gospodarczego.
Vladimir Tuchkov’s intertextual transgression: Folklore, parody, and social criticism
Authors: Dreyer Nicolas
Published: June 2022

This essay aims at analysing and illustrating a segment of the post-Soviet short fiction of the contemporary Russian writer Vladimir Tuchkov. It specifically discusses his collection of veryshort stories And he earned many dollars…: New Russian fairy-tales. These short stories exemplify many characteristics of Tuchkov’s oeuvre more generally. The discussion analyses the satirical contents of these miniature fictions, which the author places in the tradition of the Russian classics and of Russian folklore, within the theoretical context of parody, pastiche, intertextuality, and folklore. Tuchkov’s short narratives create a de-familiarised, quasi-mythological space where pre-modern, Soviet, and post-Soviet times converge. This results in the critical, satirical foregrounding of certain continuities in Russian culture, society, and mentality throughout the centuries despite the enormous political and social change, which it has experienced, as much as constituting, like Russia’s traditional fables, a critical and satirical engagement with contemporary social reality in Russia. The contribution examines the specific intertextuality with a satirical folkloristic genre as a literary expression, which reverberates with a post-Soviet readership, given its inherent concern with social structures. It is suggested that the employment of these concepts and literary forms in this combination serves to reinforce their overall effect of creating a hyperbolised, satirical representation of social reality.
„…читая в ногу души прекрасные порывы”: смех аутсайдера и русский ХХ век в Неизвестных письмах Олега Юрьева
Authors: Voloshchuk Ievgeniia
Published: June 2022

The paper deals with the specifics of outsiders’ laughter in the book Unknown letters (Неизвестные письма/Unbekannte Briefe, Russian 2014, German 2017) by a Russian-German writer Oleg Yuryev. In particular, it analyzes how Russian cultural and historical traumas of the 20th century were reinterpreted in the book from the perspective of an ironical outsider. In doing so, it focuses on a fictional letter by the writer Leonid Dobychin, which is contextualized with fictional letters of Jakob Michael Reinhold Lenz and Ivan Pryzhov, representing previous historical and cultural periods. Yuryev’s ironic reflections on the Russian historical reality and literary scene of the 20th century manifest themselves at different levels, from the positioning of outsiders’ laughter in relation to the official and marginal hierarchies of the literary canon to the postmodernist play with the traditions of literary classics. In addition, the paper addresses the inter- and/or transcultural aspect of outsiders’ laughter in Yuryev’s book.
Абсурдизация действительности в сатирической пьесе Увидеть Солсбери Виктора Шендеровича
Authors: Vorontsova Kristina
Published: June 2022

In 2018, the story of the unsuccessful poisoning of the Skripals by Russian special services shocked the world, and the further appearance of “Petrov” and “Boshirov” in an interview with Margarita Simonyan with completely implausible explanations led to the emergence of many memes and humorous works. The satirical play by Viktor Shenderovich To see Salisbury (2019) can be considered as one of the most significant reactions created by Russian-speaking society to the lies of the state. It is successfully performed abroad and, of course, has no chance of being staged in Russia. The author asks the question: what if everything that Petrov and Boshirov told in a scripted interview on the air of on Russia Today is true, and they are not unsuccessful spies, but a couple of gay lovers who are interested in Gothic cathedrals and the Charter of Liberties? Reflections on their own blurry unstable identity led the characters to an existential crisis in the spirit of the Theatre of the Absurd. This paper analyses how the absurdity of reality in the play serves to create a comic effect. Shenderovich grounds his satire based on direct citation of the precedent text of the interview, known a priori to every Russian-speaking recipient, on the intertexts of the Russian linguistic culture, fills the gaps of perception with paradoxes, and answers the questions asked by the audience after the RT broadcast (Why do the passport numbers differ by one digit? Why do the characters know Simonyan’s personal phone number? etc.).
A case report of partial bowel obstruction as the first symptom of a sizeable adnexal mucinous cystadenoma
Authors: Kirochristou Gerasimia , Stefanou Stefanos K. , Stefanou Christos K. , Flindris Stefanos , Tsiantis Thomas , Tsoumanis Periklis , Tepelenis Kostas
Published: June 2022

Objectives

Mucinous cystadenomas are among the most common benign adnexal masses. The peak incidence of mucinous cystadenoma appears between the third and fifth decades of life, but rare cases in younger and older women have also been reported. Ovarian cystic formations are usually asymptomatic at early stages, until they grow in size and various compression symptoms appear, such as abdominal discomfort, distention, nausea, vomiting, and increased urination.

Case presentation

This is a case of an 86-year-old woman with partial bowel obstruction due to a sizeable adnexal mass. The patient was submitted to exploratory laparotomy due to intestinal obstruction symptoms, the mass was removed and the final histopathological report indicated a benign mucinous cystadenoma (maximum diameter 25 cm). Physical examination was remarkable due to the large size of the mass. Computed tomography revealed the sizeable abdominal mass in contact with the uterus and the ovaries resulting in bowel compression. Exploratory laparotomy due to bowel obstruction symptoms confirmed the imaging results. The abdominal mass was removed without being ruptured, and total abdominal hysterectomy (TAH) with bilateral salpingo-oophorectomy were done.

Conclusions

Our case report highlights the clinical suspicion that is required for the diagnosis and appropriate treatment of this clinical entity. These tumors are uncommon in postmenopausal women, and when they do appear, they can be difficult to differentiate from cancer.
Highly efficient microencapsulation of phytonutrients by fractioned cellulose using biopolymer complexation technology
Authors: Balakrishnan Preetha , Gopi Sreerag
Published: June 2022

A poorly water soluble polar and non-polar bioactive complexes encapsulated in a nanocellulose-based polymeric network are the focus of this research. Ascorbic acid, resveratrol, holy basil extract, pomegranate extract, and niacin are all microencapsulated bioactive complexes that make up Zetalife®, a nutritional ingredient. It uses an interpenetrating polymeric network (IPN) with more dispersed nanocellulose and phospholipids to increase Zetalife® s bioavailability. Field Emission Scanning Electron Microscopic (FESEM) images were used in studying the morphology of encapsulated bioactive molecules. The average microbead size was determined to be 244.2 nm. After each month of storage, the sample’s microbial content was measured to assess stability. In vitro release followed a first-order kinetic model with high R2.
Performance of reinforced concrete non-prismatic beams having multiple openings configurations
Authors: Meyoof Tareq R. , Izzet Amer F. , Kharnoob Majid M.
Published: June 2022

This experimental study demonstrates the gable-reinforced concrete beams’ behavior with several number of openings (six and eight) and posts’ inclination, aimed to find the strength reduction in this type of beam. The major results found are: for the openings extending over similar beam length it is better to increase the number of posts (openings),i.e., increasing opening number led to decrease in opening area, which allows us to transmit stresses and act as lever arms between the upper and the lower chords. Also, findings revealed that the inclined posts have larger loading at the mid-point relative to vertical ones. For gables with vertical posts having six and eight openings, the ultimate strength reduction was 31.5 and 25.6%, whereas it was 29 and 17.3% for those with inclined posts, respectively.
Arterial hypertension is associated with an increased risk of metabolic complications in pediatric patient with obesity
Authors: Stępniewska Anna , Wójcik Małgorzata , Starzyk Jerzy B.
Published: June 2022

Objectives

Coexistence of arterial hypertension (AH) in children with obesity increases morbidity and shortens life. Its role as an indicator of coexisting metabolic complications is however less known. The objective of the study was to compare metabolic profiles of children with obesity and with or without AH.

Methods

We included patients aged 10–18 with the BMI Z-score ≥2. Diagnosis of AH was based on the European Society of Hypertension criteria (2016). Metabolic profiles were assessed by glucose and insulin levels taken before and after glucose load, fasting levels of triglycerides (TG), total (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, and HOMA-IR.

Results

Of 534 patients, 33.5% were diagnosed with AH. The AH patients, as compared to non-AH, had higher fasting insulin levels (22 vs. 19.7 mIU/L, p=0.04), HOMA-IR (4.5 vs. 4.0, p=0.029), and post-load glucose level (6.3 vs. 5.7, p=0.000041). No differences in the post-load insulin levels (113 vs. 100 mIU/L, p=0.056), fasting glucose (4.5 vs. 4.5 mmol/L, p=0.5), or lipids were found (TC: 4.4 vs. 4.4 mmol/L, p=0.9; LDL: 2.7 vs. 2.7, p=0.2; TG: 1.4 vs. 1.4 mmol/L, p=0.5; HDL: 1.1 vs. 1.2, p=0.3.

Conclusions

Concomitance of AH in children with obesity may be an indicator of coexisting metabolic complications.
Veridicality and the cause-effect relation in Russianesli-andraz-conditionals: experimenting with conditional perfection and logical entailment
Authors: Zevakhina Natalia
Published: June 2022

This paper experimentally investigates the role of veridicality and the cause-effect relation in the derivation of (a) conditional perfection and (b) logical entailment in Russianesli-conditionals andraz-conditionals. It provides further evidence that conditional perfection is a structurally defined phenomenon. Moreover, it presents a crosslinguistic and intra-linguistic variation in conditional connectives used in indicative and subjunctive counterfactual conditionals. Finally, confirming the causal network theory proposed in Schulz (2007,Minimal models in semantics and pragmatics: Free choice, exhaustivity, and conditionals. Amsterdam: ILLC Dissertation), the paper points out that effect-to-cause subjunctive counterfactuals are less acceptable than cause-to-effect ones.
Effect of plasma-activated water on microbial quality and physicochemical properties of fresh beef
Authors: Lotfy Khaled , Khalil Sayed
Published: June 2022

This work studies the influence of plasma-activated water (PAW) on the decontamination of beef and its influence on the color, pH, the thiobarbituric acid reactive substance values (TBARS), and total volatile basic nitrogen (TVBN) values of meat. PAW was generated using non-thermal atmospheric pressure plasma jet (NTAPPJ). He + 0.2% N2 and He + 0.2% O2 were used as worker gas to generate PAW. The PAW produced by the He + O2 plasma system exhibited a higher potential for decontamination of beef than that produced by the He + N2 plasma system. The lightness value (L*) of treated beef does not exhibit a noticeable difference with the control one. TBARS values of all treated beef were lower than the rancidity threshold but significantly greater than that of control samples. The TVBN value of control beef samples reached the decay threshold after 18 days of stockpiling, but treated beef remained good. This work reveals that PAW can potentially inhibit the growth of microorganisms in beef.