bluuebunny/crossref_metadata_2025 huggingface dataset:
BACTERIAL VAGINOSIS ASSOCIATED WITH THE ABNORMAL BODY MASS INDEX
Authors: Oktaria Icha Nur , Juniastuti Juniastuti , Hardianto Gatut
Published: September 2021

AbstractBackground: Based on data in RSUD Dr. Soetomo Surabaya, showed that during the 2018 period, bacterial vaginosis was among the top 10 most diseases. One risk factor for bacterial vaginosis is still controversial is the body mass index. The purpose of this study was to determine the association between the incidence of bacterial vaginosis with body mass index in RSUD Dr. Soetomo. Method: The research data used secondary data. This research method was cross sectional with observational analytic research design. The total samples were 158 patients, according to inclusion and exclusion criteria. The sampling technique used purposive sampling. Data analysis used chi square test. Results: The results 158 patients, divided into 79 (50%) patients with BV and 79 (50%) patients without BV. Based on BMI, 88 (55.7%) patients with normal BMI and 70 (44.3%) people with abnormal BMI. Patients with normal BMI were mostly not BV, that was 56 (63.6%) people and 32 (36.4%) people were BV positive. Patients with abnormal BMI were mostly BV, that was 47 (67.1%) people and 23 (32.9%) people did not BV. Statistical analysis showed there was a significant association between the incidence of bacterial vaginosis with body mass index (p= 0.001) with contingency coefficient 0.292. Conclusion: There is associated between the incidence of bacterial vaginosis with body mass index in RSUD Dr. Soetomo in 2017-2018.
Application of Transference Focused Psychotherapy in Borderline Personality Disorders
Authors: Ardiyani Ina Dewi , Karimah Azimatul
Published: September 2021

Borderline Personality Disorder (BPD) is a condition that is currently commonly found in daily psychiatric practice, and causes serious psychiatric disorders because it has an impact on the emergence of various other comorbid psychiatric disorders. The management of BPD is a challenge, because it is quite difficult and complex. Psychotherapy is an effective first-line therapy for BPD. Transference Focused Psychotherapy (TFP) is psychodynamic based psychotherapy that is specifically designed for BPD and is considered effective based on the specific psychopathology of BPD, namely the lack of identity integration. TFP focuses on the relationship between patient and therapist in sessions which have the aim of facilitating better behavioral control and increasing reflection and influencing regulation so as to produce identity integration that leads to a more coherent identity, better regulatory abilities, less self-destructive behavior. forming a more balanced and constant relationship, and increasing overall functioning.Keywords : Borderline Personality Disorder, Psychodynamic Psychotherapy, Transference Focused Psychotherapy.
Implementing the Nagoya Protocol on Access and Benefit-Sharing in China: the Emerging Legal Issues
Authors: Xia Nan
Published: September 2021

This Article critically examines the implementation of the Nagoya Protocol on Access and Benefit Sharing under the Convention on Biological Diversity (CBD) by the Chinese Legal system. While referring to the major provisions of the Nagoya Protocol, the Article seeks to investigate how far the Draft Regulation (2017) in China is meeting the requirements of the Nagoya Protocol and what needs to be done in giving full effect to the obligations of the Protocol.
Incision and Prediction of Risk Factors Related to Surgical Site Infection Following Cesarean Section in Chinese Women
Authors: Huang Qiuxiang
Published: September 2021

Cesarean Section (CS) is one of the most frequently executed surgical procedures in gynecology and obstetrics. After a cesarean section, surgical site infection (SSI) increases hospital stay, lengthens maternal morbidity, and upsurges treatment costs. The current study determines the prevalence and risk factors for surgical site infection following cesarean section in China. A retrospective study was conducted on 23 cases of pregnant women who underwent cesarean section and incision severe infection and detection from March 2017 to January 2020 at Wuhan Maternal and Child Healthcare Hospital in China as the study group, and 20 cases of uninfected cesarean section during the same period were selected as the control group. Data were compared with the controls based on study variables and the presence of SSI. The mean age was 31±2.6. High fever and blood loss were observed in serous SSI-infected patients. The incidence rate of severe surgical site infection was 0.15 %. SSI was observed to be expected in pregnant women who had premature rupture of membrane before surgery (p < 0.001), who underwent postoperative antibiotic therapy (p < 0.001), and the patients who had gestational diabetes mellitus (p <0.001) and hematoma (p < 0.001) during surgery. Hence, following a cesarean section, surgical site infection is common. This research discovered several modifiable risk factors. SSI is associated with multifactorial rather than a single one. The development and strict implementation of a procedure by all health care practitioners can successfully reduce and prevent infection rates following cesarean section.
Sposàrsi a Franca: tendências da nupcialidade entre imigrantes italianos no interior paulista, 1885-1930
Authors: Maritan Gonçalves José Victor
Published: September 2021

Em consonância com os estudos em Demografia Histórica e História da Família, este artigo visa a resgatar aspectos relativos à nupcialidade vivenciada pelos italianos e seus descendentes no município de Franca, interior do estado de São Paulo. A reflexão é corroborada pela historiografia recente que aponta a expansão da economia cafeeira no interior paulista como responsável por alterações no panorama demográfico por meio da atração de uma imigração internacional em massa, cujos impactos foram sentidos em diferentes espaços de ação, na família, nas relações matrimoniais, na etnicidade e integração desses grupos na sociedade brasileira entre o final do século XIX e as primeiras décadas do século XX. Combinando metodologias seriais e de microanálise para explorar os dados disponíveis nos registros de matrícula da Hospedaria de Imigrantes de São Paulo e assentos de casamento do Registro Paroquial do Arquivo da Cúria Diocesana de Franca (1885-1930), abre-se caminho para enriquecer o universo de interpretações sobre a nupcialidade nos municípios atingidos pela imigração internacional de italianos. Esse artigo examina os impactos das variáveis imigratórias nos padrões de casamento dos italianos no município e resgata aspectos da endogamia desse grupo, favorecida pelos respectivos contextos e bagagens culturais que conduziram o processo imigratório por eles vivenciado.
The Effect of Work Discipline and Motivation to Work Productivity on Production Division Employee of PT X
Authors: Shinutama Betha Pramesthi , Agung Wahyu Handaru  , Christian Wiradendi Wolor
Published: September 2021

The purpose of this study is: To find out 1) To analyze the description of work discipline, motivation on employee productivity at PT X 2) To analyze the effect of work on employee productivity at PT X. 3) To analyze the influence of motivation on employee productivity at PT X. This research was conducted on 95 employees of the PT X on Jl. Manggul Jaya, Bantargebang. 4) To determine work discipline and motivation to predict employee productivity at PT X on Jl. Manggul Jaya, Bantargebang. Data collection techniques using survey methods by distributing questionnaires which are then processed with the SPSS 25 program. This research uses descriptive and explanatory analysis. The result obtained from the regression show that there is a positive and significant influence between Work Discipline and Motivation to Work Productivity. The research model of Work Discipline and Motivation can predict Work Productivity on production division employee of PT X which on Jl. Manggul Jaya, Bantagebang Bekasi, with a value of Fcount > Ftable (61,471> 3,10) and significance (0,000 < 0,05).
The Influence of Service Quality, and Price Toward Customer Satisfaction at PT. Juragan Wifi Indonesia
Authors: Rian Muhammad Rian Ardianto , Dra. Basrah Saidani, M.Si  , Ika Febrilia, S.E., M.M
Published: September 2021

The objectives of this study are: First, To determine the influence of Service Quality on Customer Satisfaction of PT Juragan Wifi Indonesia. Second, To determine the influence of Price on customer satisfaction of PT Juragan Wifi Indonesia. This research is conducted on 100 customers of PT. Juragan Wifi Indonesia that spread across Jakarta, Bogor, Depok, Tangerang, and Bekasi. Data is collected using a questionnaire with 5 point of likert scale, namely by reaching consumers by distributing the questionnaires which are then processed using the SPSS program. The results shows that service quality, and price provided by PT Juragan Wifi are valid and able to meet consumer expectations. Consumers of PT Juragan Wifi also have high level of satisfaction. Based on the results of hypothesis testing, it can be concluded that service quality has a positive effect on customer satisfaction, and price has a positive effect on customer satisfaction.
THE EFFECT OF CAREER DEVELOPMENT AND WORK DISCIPLINE TO JOB SATISFACTION OF PROGRAMMING DEPARTMENT EMPLOYEES AT PT. X
Authors: Anti Purnamasari  , Dr. Agung Wahyu Handaru, ST, M.M.  , Dr. Widya Parimita, S.E., M.P.A
Published: September 2021

The purpose of this study was to determine the effect of Career Development and Work Discipline on the work of Programming employees at PT. X. The subject of this research is PT. X, which is one of the private TV stations in Indonesia and located in Jakarta. The population of this study was 116 people, and the sampling method used was saturated sampling, so the number of samples in this study was also 116 people. This research used the multiple linear regression analysis method in analyzing research data. The results showed that Career Development and Work Discipline had a significant positive effect on work, either separately or simultaneously. This implies that if there is an increase of career development and/or employees’ work discipline, the job satisfaction felt by employees will also increases.
Maré de Dentro: Arte, Cultura e Política no Rio de Janeiro
Authors: Poets Desireé , Stephenson Jr. Max O.
Published: September 2021

O Complexo da Maré, localizado na Zona Norte do Rio de Janeiro e com cerca de 140 mil moradores, é o maior aglomerado de favelas do Brasil. Como este livro demonstra, as 16 comunidades que compõem a Maré são vibrantes e diversas, apesar de serem frequentemente representadas de maneira pejorativa. Maré de Dentro: Arte, Cultura e Política no Rio de Janeiro acompanha a exibição de mesmo nome, criada por um time internacional de acadêmicos, organizadores comunitários e artistas brasileiros e estadunidenses. Por meio de retratos de família, fotografias de rua, documentários e textos, a exibição documenta as vidas dos moradores da Maré. Este livro apresenta uma seleção das fotografias que fazem parte do acervo da exibição, tiradas pelo fotojornalista Antonello Veneri em colaboração com Henrique Gomes, produtor cultural, morador e organizador comunitário da Maré, entre 2013 e 2019, quando o Rio de Janeiro sediou a Copa do Mundo de 2014 e os Jogos Olímpicos de 2016. As fotografias, intimistas e profundamente humanas, evidenciam a diversidade e resiliência das comunidades da Maré e expõem os entraves que seus moradores confrontam no seu dia a dia, rompendo, deste modo, com as narrativas que os estigmatizam. Os ensaios incluídos neste volume, escritos pelos criadores, curadores e colaboradores deste projeto, contextualizam as fotografias. O texto de Andreza Jorge, moradora e pesquisadora da Maré, por exemplo, levanta uma pergunta fundamental: o que faz da Maré de Dentro uma exibição tão comovente para tantas pessoas de diferentes partes do mundo? Parte da resposta reside no poder da arte de nos fazer reconsiderar imaginários e estruturas dominantes e, com isso, abraçar estratégias políticas e culturais que promovam a construção de uma sociedade verdadeiramente igualitária e democrática.
Summary of Collaborative Wildlife Protection and Recovery Initiative (CWPRI) conservation workshop : Least Bell’s Vireo
Authors: Jung Jacob , Hertz Stephanie , Fischer Richard
Published: September 2021

This special report summarizes the regional workshop held 24–26 April 2018 at the US Fish and Wildlife Service (USFWS) Ecological Services Office in Carlsbad, California on the importance of collaboration among federal, state, and nongovernmental agencies to facilitate the recovery of threatened and endangered species (TES). This workshop focused primarily on one species, the least Bell’s vireo (LBVI), and how to achieve full recovery and eventual delisting through agency partnerships. A major theme of the workshop was applying the Endangered Species Act (ESA) Section 7(a)(1) conservation planning process as a building block towards recovery of LBVI—as well as other threatened, endangered, and at-risk riparian species within the Southwest. The main objective of this workshop was to assemble an interagency and interdisciplinary group of wildlife biologists and managers to detail how the Section 7(a)(1) conservation planning approach, in consultation with the USFWS, can assist in the recovery of LBVI primarily on federal lands but also other public and private lands. Goals of this workshop were to (1) review Section 7(a)(1); (2) outline LBVI ecosystem processes, life history, threats, and conservation solutions; and (3) develop and organize agency commitments to collaborative conservation practices.
Pull-through Procedure for Hirschsprung’s Disease with Simultaneous Stoma Closure: Insights for Limited-Resource Settings from Mbarara, Uganda
Authors: Oyania Felix , Kotagal Meera , Wesonga Anne Shikanda , Nimanya Stella Alice , Situma martin Samuel
Published: September 2021

Background: In many resource-limited settings, patients with Hirschsprung’s Disease (HD) undergo initial diverting colostomy, followed by pull-through, and lastly, colostomy closure. This approach allows for decompression of dilated and thickened bowel and improved patient nutritional status. However, this 3-stage approach prolongs treatment duration, with significant stoma morbidity, costs, and impact on quality of life (QOL).Aim: To determine whether pull-through for HD can safely be performed with simultaneous stoma closure, reducing treatment approach from three to two stages.Patients and Methods: Children with HD and diverting colostomy were prospectively followed as they underwent pull-through with simultaneous stoma closure. Their in-hospital course, and 3-month outpatient course, were assessed for postoperative complications. Patients with total colonic HD, redo pull-through, and residual dilated colon were excluded from the study. Results: Of the 20 children, seventeen were male (n = 17, 85%). All patients had rectosigmoid HD. The median weight, age at colostomy formation, and age at pull-through were 11.05 kg (interquartile range [IQR] 10-12.75), 0.9 years (IQR 0.25-2.8), and 2.08 years (IQR 1.28-2.75) respectively. Mean duration with colostomy before pull-through was 1.1 years (SD 1.51). Median hospital length of stay was 6 days (IQR 5-7). Early complications included anastomotic leak (n=1), perianal skin excoriation (n=2), surgical site skin infection (n=3_, and burst abdomen (n=1). Longer-term complications included stricture (n=1, 5%) and enterocolitis (n=2, 10%).Conclusion: In this small case series, we have demonstrated that pull-through with simultaneous stoma closure can be safely performed in resource-constrained settings. Further studies are needed to understand the QOL and economic impact of this change in management for HD patients.
Analysis of the Retina, Choroid, and Optic Nerve Structures using Optical Coherence Tomography in Patients Recovered from Coronavirus Disease 2019
Authors: Kose Alev Ozcelik , Yenerel Nursal Melda , Balcı Sevcan , Yıldız Merve Beyza , Imamoglu Serhat , Mangan Mehmet Serhat
Published: September 2021

Purpose: To evaluate retina, choroid and optic nerve in patients recovered from coronavirus disease 2019 (COVID-19).Methods: Fifty healthcare professionals who had COVID-19 infection- confirmed with polymerase chain reaction from nasopharyngeal swabs- and were at least one-month swab specimen negativeness after the treatment (CG) compared with 40 sex-matched healthy controls (HG). The dilated fundoscopy examination and optical coherence tomography (OCT) scanning were performed. The fundoscopy examination, subfoveal and peripapillary choroidal vascularity index (CVI), retinal nerve fiber layer (RNFL) and Bruch membrane opening (BMO)-minimum rim width (MRW) were evaluated.Results: The mean subfoveal and peripapillary CVI were found significantly higher in the CG than the HG (p < 0.001, p < 0.001). In the CG, two (4 %) patients had cotton-wool spot (CWS), one (2 %) patients had retinal hemorrhage. Discussion: COVID-19 might be associated with increased subfoveal and peripapillary CVI and retinal changes after the healing period.
Primary Gross Tumor Volume is Prognostic and Suggests Treatment in Upper Esophageal Cancer
Authors: Chen Yuanmei , Huang Qiuyuan , Chen Junqiang , Lin Yu , Huang Xinyi , Wang Qifeng , Yang Yong , Chen Bijuan , Ye Yuling , Zheng Binglin , Qi Rong , Chen Yushan , Xu Yuanji
Published: September 2021

Background: To aid clinicians strategizing treatment for upper esophageal squamous cell carcinoma (ESCC), this retrospective study investigated associations between primary gross tumor volume (GTVp) and prognosis in patients given surgical resection, radiotherapy, or both resection and radiotherapy. Methods: The population comprised 568 patients with upper ESCC given definitive treatment, including 238, 216, and 114 who underwent surgery, radiotherapy, or combined radiotherapy and surgery. GTVp as a continuous variable was entered into the multivariate Cox model using penalized splines (P-splines) to determine the optimal cutoff value. Propensity score matching (PSM) was used to adjust imbalanced characteristics among the treatment groups. Results: P-spline regression revealed a dependence of patient outcomes on GTVp, with 30 cm3 being an optimal cut-off for differences in overall and progression-free survival (OS, PFS). GTVp ≥ 30 cm3 was a negative independent prognostic factor for OS and PFS. PSM analyses confirmed the prognostic value of GTVp. For GTVp < 30 cm3, no significant survival differences were observed among the 3 treatments. For GTVp ≥ 30 cm3, the worst 5-year OS rate was experienced by those given surgery. The 5-year PFS rate of patients given combined radiotherapy and surgery was significantly better than that of patients given radiotherapy. The surgical complications of patients given the combined treatment were comparable to those who received surgery, but radiation side effects were significantly lower. Conclusion: GTVp is prognostic for OS and PFS in upper ESCC. For patients with GTVp ≥ 30 cm3, radiotherapy plus surgery was more effective than either treatment alone.
Intrinsic Value of Incentives Compared To Salaries: Can Organization Stop Paying Salaries?
Authors: Raju Valliappan
Published: September 2021

This research weighs significantly on challenging the present practice of compensation and rewards. Traditionally or conventionally, the organization reciprocates the gratitude to their employees in monetary terms. Non-monetary rewards being an exclusive section, it is not discussed in this research paper. Among the direct rewards, whether the companies should practice compensating their employees a fixed salary or pay only incentives for the tasks that are achieved? this question may not be welcomed by any employee as it touches the sensitive quotient. Nevertheless, organizations need to understand the right practice in the right era by implementing an intelligent framework. Equity Theory developed by Adams is laid as a foundation to encounter the present unfair reward system. Concurrent mixed-mode method research is done with 162 respondents (quantitative) and 15 respondents (qualitative). Multivariate analysis using SmartPLS 3.3.3 is executed to assess the measurement model and structural model to analyze the covariance between the constructs. The outcome of research claims that it is an ideal practice to implement task-based incentives in organizations rather than paying fixed salaries irrespective of the size or productivity of companies.
Design of Enterprise Human Resources Decision Support System based on Data Mining
Authors: Li Jian
Published: September 2021

The management and development of human resources have become one of the core contents of enterprise operation and management. At first, it can only be used as an auxiliary tool in human resources business management, then it can develop various personnel transaction processing subsystems with relatively independent modules and perfect functions, and then realize the integration of various subsystems, Form a relatively complete set of human resource information management system. In recent years, with the rapid development of data mining technology, more and more enterprises begin to pay attention to the completion of various decision-making activities in management through the assistance of computer information systems. This paper designs an enterprise human resources decision support system based on data mining, which can more effectively support human resources management business informatization, data standardization, intelligent decision analysis, optimize human resources business process, improve human resources management business efficiency, provide more effective decision support for enterprise management and promote enterprise development.
Glitter Interference On Photosynthetic Rates of A Submerged Macrophyte (Egeria Densa)
Authors: Yoshida Luana Lume , Bianchini Irineu , Cunha-Santino Marcela Bianchessi da
Published: September 2021

This study analyzed the photosynthetic rates (by the light and dark bottle method) of the submerged macrophyte Egeria densa in the presence of three concentrations of glitter: 0.0235 g (T1/T4), 0.0117 g (T2/T5) and 0.0058 g (T3/T6), as well in its absence (control treatment, CT1 and CT2). About 800 apical fragments of E. densa were distributed in 8 subtreatments (4 under light conditions and 4 in the dark to obtain respiration), with 100 specimens in each. The CT showed the highest net photosynthesis rate (PN = gross photosynthetic (PG) rate subtracted from respiration (RD)) of E. densa, with 59.3%, 32.8%, 13.0% higher compared to T1, T2 and T3, respectively. At T3 it was observed the highest mean respiration rate (RE) o E. densa and at T1, the lowest. Comparing PN with RD, we found that the photosynthetic process was, on average 3.5, 2.47, and 2.93 times higher in CT, T1, T2, and T3, respectively. The presence of glitter may have increased the reflectance of water, as it is a suspended particle and reflected light intensely, considering that it is a metal coated particle. Glitter reflects radiation, decreasing the light absorption process, compromising the use of underwater radiation by E. densa. The microplastic interferes with the absorption of light necessary for photosynthetic processes, reducing them, enabling an imbalance in the ecosystem.
Exploring the relationship between the urban built environment and elderly pedestrian mobility in South Asian cities
Authors: Parida Debadutta , Khan Rahaman Rubayet , K Neethilavanya
Published: September 2021

Cities in South Asia have traditionally been dominated by pedestrians for their daily trips. As the elderly population is increasing in the last two decades, the dynamics of designing appropriate walkways to serve elderly people are getting more attention from urban planning scholars and policymakers alike. However, few studies in planning in the context of southern cities have considered the significant issue of elderly mobility and walkability in cities in South Asia beyond the realm of large metropolitan cities. In this paper, we attempt to understand the challenges encountered by elderly pedestrians in existing street conditions and summarizes information that may be useful for enhancing elderly mobility. Using cases of Rourkela in India and Khulna city in Bangladesh, we have collected both primary and secondary information by conducting a structured questionnaire survey in both cities at a similar period. Further to this, we analyzed statistical models to understand relationships among built environment and mobility issues based on subjective evaluation (i.e., infrastructure, street design, lighting, overcrowding condition, and encroachment). Most of the elderly pedestrians surveyed in both cities demand improvement of micro-scale urban design features and planning guidelines that they assume are absent in the statutory planning documents. This study may be employed as a useful document for city-level planning taking into account elderly perception about the built environment and their mobility concerns in future policy and planning projects. Consequently, a more comprehensive study may be incorporated highlighting elderly pedestrian’s mobility within the formal/informal transportation planning system.
Electronic regulation of Ni single atom by confined Ni nanoparticles for fast and energy-efficient CO2 electroreduction
Authors: Ren Wenhao , Tan Xin , Jia Chen , Krammer Anna , Sun Qian , Qu Jiangtao , Smith Sean , Schueler Andreas , Hu Xile , Zhao Chuan
Published: September 2021

Electrocatalytic CO2 to CO conversion is approaching the industrial benchmark. Currently, Au electrodes show the best performance, whereas non-precious metal catalysts exhibit inferior activity. Here we show a densely populated Ni single-atom on nanoparticle catalyst (NiSA/NP) via direct solid-sate pyrolysis, where Ni nanoparticles donate electrons to Ni(i)-N-C sites via carbon nanotubes network, achieves a high CO current of 352 mA cm− 2 at -0.55 V vs RHE in an alkaline flow cell. When coupled with a NiFe-based oxygen evolution anode into a zero-gap membrane electrolyser, it delivers an industrial-relevant CO current of 310 mA cm− 2 at a low cell voltage of -2.3 V, corresponding to an overall energy efficiency of 57%. The superior CO2 electroreduction performance is attributed to the enhanced adsorption of key intermediate COOH* on electron-rich Ni single atom, together with the dense active sites.
The University of West Florida Campus Ecosystem Study: Age-Diameter and Growth Relationships of Longleaf Pine Using Hurricane-Induced Windthrows
Authors: Gilliam Frank S. , Patten Heather N. , Rabinowitz Sarah K.
Published: September 2021

The campus of the University of West Florida was constructed among second-growth longleaf pine (Pinus palustris) stands that survived extensive logging in the Florida Panhandle. Previous studies on longleaf pine on the main UWF campus have estimated that 65% of these pines are 75 to 125 years old, with estimates based on a model from old-growth longleaf in southern Georgia. To obtain more accurate age data, one can use an increment corer to collect samples from live trees on site; more accurately, disks can be collected from recently fallen trees. On 16 September 2020, Hurricane Sally impacted UWF as a Category 2 storm, with winds reaching 125 kph. Our study took advantage of longleaf pines blowdowns by Sally to obtain cross-sections for age determinations. Two on-campus natural areas were chosen for sampling: the Edward Ball Nature Trail and the Baars-Firestone Wildlife Sanctuary. For each sampled section, diameter at breast height (DBH) and number of annual rings were recorded. Based on a total of 50 sampled trees, linear regression revealed a highly significant (P<0.00001; r2 =0.84) relationship between DBH and age. Applying this to DBH measures of 2,165 stems on the main campus indicates that the oldest longleaf pines are ~130 years old (mean age = 63.9±0.4 yr), consistent with cessation of historically wide-spread harvesting in the region. Mean age for the Trails site (55.7±1.6 yr) was significantly lower than that of the Sanctuary (66.7±2.0 yr), suggesting that they represented sites of contrasting land-use history. Direction of stem windthrows did not vary between natural areas and was consistent with characteristics of the eyewall of Hurricane Sally with strongest wind gusts moving from a southeast to northwest direction.
Design and Experimental Study of Progressive Spring for Formula Student Race Car
Authors: Patil Anmol Shripad , Nandi Eshita , Punekar Prasad Nanasaheb , Wagh Suyash
Published: September 2021

The purpose of carrying out the present work is to design, manufacture & test the progressive springs on an FS vehicle. This is one type of helical spring with a variable spring rate. The main purpose of designing progressive springs is to avail all the advantages of the variable spring rate over the linear spring rate and better ride quality along with roll control, compared to linear rate springs. We took several factors of vehicle dynamics under consideration before settling on progressive springs. Before starting with the design procedure, we had set objectives and followed the standard methodology of spring design to get the required output. Along with that, we took design philosophy under consideration. We reviewed all the parameters before finalizing the spring material as it is one of the major factors. We carried out all the necessary design calculations to complete the dimensions and stiffness of the spring. The conclusion helped us to achieve better ride quality and roll control accompanying the optimized spring design satisfying all the necessities such as load, stiffness, and deflection of progressive springs.
Intrinsic ferroelectricity in Y-doped HfO2 thin films
Authors: Yu Yun , Buragohain Pratyush , Li Ming , Ahmadi Zahra , Zhang Yizhi , Li Xin , Wang Haohan , Tao Lingling , Wang Haiyan , Shield Jeffrey , Tsymbal Evgeny , Gruverman Alexei , Xu Xiaoshan
Published: September 2021

Ferroelectric HfO2-based materials hold great potential for widespread integration of ferroelectricity into modern electronics due to their robust ferroelectric properties at the nanoscale and compatibility with the existing Si technology. Earlier work indicated that the nanometer crystal grain size was crucial for stabilization of the ferroelectric phase of hafnia. This constraint caused high density of unavoidable structural defects of the HfO2-based ferroelectrics, obscuring the intrinsic ferroelectricity inherited from the crystal space group of bulk HfO2. Here, we demonstrate the intrinsic ferroelectricity in Y-doped HfO2 films of high crystallinity. Contrary to the common expectation, we show that in the 5% Y-doped HfO2 epitaxial thin films, high crystallinity enhances the spontaneous polarization up to a record-high 50 µC/cm2 value at room temperature. The high spontaneous polarization persists at reduced temperature, with polarization values consistent with our theoretical predictions, indicating the dominant contribution from the intrinsic ferroelectricity. The crystal structure of these films reveals the Pca21 orthorhombic phase with a small rhombohedral distortion, underlining the role of the anisotropic stress and strain. These results open a pathway to controlling the intrinsic ferroelectricity in the HfO2-based materials and optimizing their performance in applications.
Dynamic Analysis of Serum MMP-7 and Its Relationship with Disease Progression in Biliary Atresia: A Multicenter Prospective Study
Authors: Chi Shuiqing , Xu Peipei , Yu Pu , Cao Guoqing , Wang Haibin , Ye Yongqin , Li Shuai , Zhou Yun , Li Xiangyang , Zhou Ying , Zhang Xi , Niu Huizhong , Xu Lei , Cai Pengcheng , Tang Shaotao
Published: September 2021

PurposeWe aimed to assess the dynamic changing trend of serum matrix metalloproteinase-7 (MMP-7) in BA patients from diagnosis to LTx to further elucidate its clinical value in diagnosis and prognoses and its relationship with disease progression.MethodsIn this multicentre prospective study, a total of 440 cholestasis patients (direct bilirubin level of > 17 μmol/L) were enrolled. Serum and stool MMP-7 levels were measured using an enzyme-linked immunosorbent assay at different time points and analysed. The polymorphism of MMP-7 was assessed to explore the possible reasons for the low value in BA patients.Results:In neonate biliary atresia patients, using a cut-off value of > 26.73 ng/ml, serum MMP-7 had a AUC of 0.954. A genetic mutation (G137D) and rapid degradation of MMP-7 in serum samples could cause low MMP-7 levels in serum of BA patients. Four dynamic patterns of serum MMP-7 post-KPE were associated with prognosis. A high concentration of MMP-7 in the stool is linked to a decreased serum MMP-7 concentration. MMP-7 showed a mediation effect on the association between inflammation and liver fibrosis in BA patients. Serum MMP-7 was the only significant predictor at six weeks post-KPE and the most accurate predictor at three months post-KPE of survival with the native liver (SNL) in two years.Conclusion:As one of the critical factors associated with BA occurrence and progression, serum MMP-7 can be used for early diagnosis of BA and post-KPE MMP-7 level is the earliest prognostic biomarker so far.
Higher Nursing Care Level is Associated with Higher Incidence of Blood Culture Contamination in the Emergency Department: A Case-Control Study
Authors: Shigeno Ayami , Homma Yosuke , Matsumoto Taiga , Tanaka Shun , Onodera Ryuta , Oda Rentaro , Funakoshi Hiraku
Published: September 2021

Background

Blood culture is critical in treating infectious diseases, but contamination occurs in 0.6–12.5% of all samples. This leads to unnecessary intervention, inappropriate antibiotic use, and excess cost. Few studies have tackled patient factors, such as nursing care level, that could possibly affect contamination rates. Thus, this study aimed to explore the association between patients’ nursing care levels and blood culture contamination.
Methods

This is a single centered, retrospective, case-control study of adult patients whose blood culture specimens were taken in the emergency department between April 2018 and July 2019. The study was conducted in a 344-bed, urban, acute care community hospital in Chiba prefecture, Japan. We included patients aged 20 years and above, with two or more sets of blood cultures. The case group included patients with false positive blood culture results with contamination; the control group included patients with true positive or true negative blood culture results without contamination. We randomly selected two control patients per case. Patients’ age, sex, nursing care level, ambulance usage, housing status, Glasgow Coma Scale, and hospital arrival time were obtained from the patients’ medical charts.
Results

Of the 5,130 patients, 686 patients got positive blood culture results. Of the 686 patients, 35 patients were included in the case group, and 70 were randomly selected from the non-contaminated group and included in the control. In multivariate analysis, patients with contaminated blood cultures had a higher nursing care level (odds ratio: 5.24; 95% confidence interval: 1.47 to 18.70; P = 0.02).
Conclusions

A higher nursing care level is associated with a higher incidence of blood culture contamination in the emergency department. Careful and appropriate procedures are required for patients with a higher nursing care level.
The Association of the Consumption Time for Different Food with the Cardiovascular Disease and All-Cause Mortality Among Diabetes Patients
Authors: Jiang Wenbo , Song Qingrao , Zhang Jia , Chen Yunyan , Sun Changhao , Li Ying , Han Tianshu , Wei Wei
Published: September 2021

Background: This study aims to investigate whether food consumed time and distribution at three-meals is associated with long-term survival among the people with diabetes. Methods:This study included 4,699 diabetes patients participating in the National Health and Nutrition Examination Survey from 2003 to 2014. Food consumed across a day including the forenoon, afternoon, evening, were divided into quantiles based on their distribution. Cox proportional hazards regression models were used to analyze the survival relationship between food intakes time and distribution (with a constant quality and quantity) and mortality. Results:After adjustment for multiple covariates, in the forenoon, compared to the participants with diabetes in the lowest consumption quantile of potato and starchy-vegetable, participants with diabetes in the highest consumption quantile had lower mortality risk of CVD(HRpotato=0.52, 95%CI: 0.38-0.87; HRstarchy-vegetable= 0.51, 95%CI: 0.29-0.90). In the evening, the highest quantile of dark-vegetable intake is related to lower mortality risk of CVD(HR=0.64, 95%CI: 0.45-0.92) and all-cause(HR=0.81, 95%CI: 0.66-0.99), whereas participants in the highest quantile of intakes of refined grain and processed meat are more likely to die due to CVD(HRrefined-grain=1.54, 95%CI:1.10-2.15; HRprocessed-meat=1.83, 95%CI:1.20-2.77) and all-cause(HRrefined-grain=1.29, 95%CI:1.01-1.65; HRprocessed-meat=1.37, 95%CI:1.06-1.75). Iso-calorically switching 0.1 serving refined grain or processed meat consumed in the evening to the forenoon, and 0.1 serving dark vegetable consumed in the afternoon to the evening reduced the risk of CVD mortality.Conclusions:Higher intake of potato, starchy-vegetable in forenoon, dark-vegetable in the evening, and lower intake of refined-grain and processed-meat in the evening was associated with better long-term survival in people with diabetes.
Atypical Papillary Thyroid Carcinoma with Squamous Metaplasia and RET/NRAS/TERT/PIK3CA Mutations: A Case Report
Authors: Li Zhenyu , Huang Haiping , Guo Dongfang , Feng Yujie , Zhang Jing , Jiang Qingming
Published: September 2021

Background: Papillary thyroid carcinoma (PTC) with squamous metaplasia is a relatively rare and special subtype adenocarcinoma of thyroid which involves multiple genetic changes. We reported a rare case of atypical PTC with squamous metaplasia and RET/NRAS/TERT/PIK3CA mutations which was confirmed after surgical resection pathologically. Case summary: A 2.5×2.5×2 cm3, smooth, hard, clear boundaries and solid nodule on the left thyroid gland was found on relevant physical examination of the patient. And then, the unilateral radical resection of thyroid carcinoma was performed after diagnosing. The tumor cells were squamous metaplasia and arranged in structures with diffuse growth pattern microscopically. At high magnification, stretched nucleus, nuclear grooves and internuclear pseudoinclusions in tumor cells were detected, and the follicular epithelium cells were atypical. Immunohistochemical staining shown strong positiveness of CK19, TTF-1, P40 and Galectin-3, partial positiveness of TG of tumor cells and negativeness of Calcitonin, which could exclude medullary thyroid carcinoma (MTC). Furthermore, first generation sequencing of 18 PTC related genes techniques shown RET, NRAS, TERT and PIK3CA was mutated. Conclusion: Genetic detection is vital to the diagnosis of thyroid adenocarcinoma, especially for the PTC with atypical morphology or rare metaplasia
Real Life Experience of Patients With Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma Treated With Neoadjuvant Chemotherapy: a Turkish Oncology Group Study
Authors: Basoglu Tugba , erol cihan , sakin abdullah , özden ercan , çabuk devrim , çılbır ebru , özyükseler deniz tataroğlu , ayhan murat , şendur mehmet ali , doğan mutlu , öksüzoğlu berna , eryılmaz melek karakurt , er özlem , taşçı elif şenocak , doğan nelihan , dülgar özgecan , özen miraç , hacıbekiroğlu ilhan , öner irem , bekmez esma türkmen , yıldırım hasan çağrı , yalçın şuayib , paydaş semra , yekedüz emre , aksoy asude , özçelik melike , oyman abdilkerim , almuradova elvina , karabulut bülent , demir nazan , dinçer murat , erdem dilek , ak naziye , inal ali , salim derya kıvrak , deniz gülhan ipek , gülmez ahmet , kaçan turgut , özdemir özlem , alan özkan , ünal çağlar , turhal serdar , karakaş yusuf , yumuk perran fulden
Published: September 2021

PurposeNeoadjuvant chemotherapy(NACT) in gastroesophageal junction(GEJ) and gastric cancer(GC) was shown to improve survival in recent studies. We aimed to share our real-life experience of patients who received NACT in order to compare the efficacy and toxicity profile of different chemotherapy regimens in our country.Methods This retrospective multicenter study included locally advanced GC and GEJ cancer patients who received NACT, and had pathological response evaluation between 2007 and 2021. Relation between CT regimens and pathological evaluation were analyzed. Results A total of 728 patients from 45 oncology centers in Turkey were included. Median age at the time of diagnosis was 60 (range: 18-68). Most frequent NACT regimens used were FLOT (65%), DCF (18%) and ECF (8.1%), respectively. In the total study group pCR rate was 8.2%, R0 resection rate 88.5%, and D2 dissection rate was 66.8%. Rate of pCR and near-CR (26.4%), and R0 resection (92.6%) were higher in FLOT arm (p= 0.005 and <0.001). Patients who received FLOT had significantly higher chemotherapy-related toxicity rate compared to patients who received other regimens (p=0.02).Median follow-up time was 17 months (range: 3-106 months). Estimated median overall survival (OS) was 59.4 months (95% CI: 32.9-86.0) and disease-free survival (DFS) was 47.6 months (95% CI: 24.4-70.8). The highest 5-year estimated OS rate was also shown in FLOT arm (58%). ConclusionIn our real-life study, FLOT regimen has superior survival outcome despite worse toxicity profile. Clinicians should tailor treatment regimens according to patients’ multifactorial status and comorbidities for to obtain best outcomes.
The Decrease In The Anxiolytic Effect of Morphine After Repeated Use of The Drug In Rats is Associated With Inflammatory Cytokine Signaling Pathways In The Prefrontal Cortex
Authors: Ahmadi Shamseddin , Talvar Shiva Mohammadi , Masoudi Kayvan , Zobeiri Mohammad
Published: September 2021

We aim to examine anxiety-like behaviors and expression of specific genes complicated in neuroinflammation in the prefrontal cortex (PFC) after repeated use of morphine. A group of male Wistar rats received injections of morphine (10 mg/kg) twice a day for eight days while a control group received saline (1 ml/kg) instead of morphine. On days 1 and 8, anxiety-like behaviors were evaluated using a light/dark box test. On day 8, opioid dependence was confirmed by measuring the behavioral expression of morphine withdrawal precipitated with naloxone. Expression of neuroinflammation genes were also evaluated at mRNA levels in the PFC on day 8. The results revealed that morphine induced anxiolytic-like effects on day 1, which significantly decreased after the repeated injection of the drug on day 8. The results also revealed that repeated morphine injection significantly increased the mRNA level of Il1, Tnfα, and Il6 but decreased Il1r and Tnfr while increased Il6r in the PFC. The gene expression results also revealed a significant decrease in Tlr1 but not in Tlr4 in the PFC of morphine-dependent rats. Although Erk1 expression had no significant alteration but p38 increased and Jnk3 decreased significantly in the PFC in morphine-dependent rats. Creb and Nfkb significantly increased but Fos expression decreased. Let-7c, mir-133b, and mir-365 also significantly increased in the PFC in morphine-dependent rats. We conclude that the alteration in neuroinflammatory pathways at gene expression level in the PFC may party underlie neuroadaptive changes leading to the decrease in anxiolytic effect of morphine in dependent rats.
Dual-Block Elastic Stain Significantly Increasing Visceral Pleural Invasion(VPI) Positivity and Analysis of Potential Predictors of VPI in Peripheral Non-Small Cell Lung Cancer
Authors: Li Shaoling , Huang Yan , Zhang Liping , Dong Zhengwei , Wu Wei , Zhang Wei , Wu Chunyan , Hou Likun
Published: September 2021

Background: Visceral pleural invasion (VPI) is a critical component in the staging of peripheral non–small cell lung carcinoma (NSCLC). Single tumor tissue block for elastic stain is conducive to identifying pleural invasion in routine pathologic examination. We aim to investigate whether dual-block elastic stain increase VPI positivity compared with single-block elastic stain, further analyze the potential predictors of VPI status.Methods: Resected 8419 consecutive peripheral NSCLC cases including tumor size≤3cm 6008 patients were retrospectively reviewed. Total cases were divided into a cohort using one tumor tissue paraffin block (single-block group, n=5184) and a cohort using dual tumor tissue paraffin blocks (dual-block group, n=3235) for elastic stain. Each case was performed with Victoria-blue van Gieson staining to assess VPI status. The clinicopathologic features of patients were collected from the electronic medical record system.Results: The overall incidence of VPI was 12.4% (1047/8419) in peripheral NSCLC patients. The VPI positivity detected by dual-block elastic stain was significantly higher than that by single-block elastic stain (17.7% (573/3235) v.s. 9.1% (474/5184), P＜0.001). The presence of VPI in T1 ≤3cm patients detected by single and dual block elastic stain was 6.3% (235/3730) and 12.0% (273/2278), respectively (P＜0.001). Therefore, 5.7% T1 patients (stage IA) are additionally upstaged to T2a (stage IB) by dual block elastic stain. But the incidence of VPI in pT2a patients had no significant difference between single-block group and dual-block group (16.8% vs 17.1%, P=0.916). The lymphovascular invasion, lymph node metastasis, poor differentiated carcinomas and the presence of STAS status could be well significant predictors of VPI (P＜0.001). Area under the ROC curve of adenocarcinoma morphology was 0.263 for lepidic pattern, 0.544 for acinar and papillary pattern, and 0.720 for micropapillary and solid pattern in predicting invasion of pleura.Conclusion: Our results indicated that using dual-block elastic stain identify more VPI positive T1 NSCLC patients who are upstaged to T2a and could benefit from optimal management after post-operation. The application of dual-block elastic stain is an efficient and practical method to detect VPI, especially for patients with high-risk prognostic factors.
Sensitivity of The Stripe-Faced Dunnart, Sminthopsis Macroura (Gould 1845), To The Phenyl Pyrazole Insecticide, Fipronil, Toxicological Signs And Implications For Pesticide Risk Assessments In Australia
Authors: Story Paul , Hinds Lyn A , Henry Steve , Warden Andrew C. , Dojchinov Greg
Published: September 2021

A lack of toxicity data quantifying responses of Australian native mammals to agricultural pesticides prompted an investigation into the sensitivity of the stripe-faced dunnart, Sminthopsis macroura (Gould 1845) to the insecticide, fipronil (5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinyl pyrazole, CAS No. 120068-37-3). Using the Up-And-Down method for determining acute oral toxicity in mammals, derived by the Organisation for Economic Cooperation and Development (OECD), median lethal dose estimates of 990 mg kg− 1 (95% confidence interval (CI) = 580.7–4770.0 mg kg− 1) and 270.4 mg kg− 1 (95% CI = 0.0 - >20000.0 mg kg− 1) were resolved for male and female S. macroura respectively. The difference between median lethal dose estimates for males and females may have been influenced by the increased age of two female dunnarts. Further modelling of female responses to fipronil doses used the following assumptions: (a) death at 2000 mg kg− 1, (b) survival at 500 mg kg− 1 and (c) a differential response (both survival and death) at 990 mg kg− 1. This modelling revealed median lethal dose estimates for female S. macroura of 669.1 mg kg− 1 (95% CI = 550–990 mg kg− 1; assuming death at 990 mg kg− 1) and 990 mg kg− 1 (95% CI = 544.7–1470 mg kg− 1; assuming survival at 990 mg kg− 1). These median lethal dose estimates are 3–10-fold higher than the only available LD50 value for a similarly sized eutherian mammal, Mus musculus (L. 1758; 94 mg kg− 1) and that available for Rattus norvegicus (Birkenhout 1769; 97 mg kg− 1). Implications for pesticide risk assessments in Australia are discussed.