bluuebunny/crossref_metadata_2025 huggingface dataset:
RECENSIÓN. ARMENTA DEU, TERESA (2021) Derivas de la justicia. Tutela de los derechos y solución de controversias en tiempos de cambios, Madrid, Marcial Pons, 347 pp.
Authors:   Pontificia Universidad Católica de Valparaíso, Romero Rodríguez Sophía
Published: March 2022

El Derecho procesal es una disciplina cuya base científica es relativamente nueva.1 Durante el siglo XIX, la principal ocupación de la doctrina fue la diferenciación entre derecho procesal y derecho sustantivo, además del desarrollo de las instituciones teóricas que han permitido construir sus núcleos dogmáticos: jurisdicción, acción y proceso.Sin embargo, durante el siglo XX, especialmente en su segunda mitad, la atención de algunos sectores de la doctrina se situó en los problemas de acceso a la justicia, y los instrumentos adecuados para entregar una respuesta estatal rápida a los justiciables frente a sus necesidades de protección jurídica. Digo estatal, porque en varias de estas concepciones, la desjudicialización y el uso de los métodos adecuados de solución de controversias, constituyen respuestas igualmente válidas en comparación a la decisión jurisdiccional, bajo el reconocimiento de la limitación propia de los recursos económicos destinados a la satisfacción de los derechos, tanto en el proceso civil como en el proceso penal.
Speculations on Difference between Tricyclic and Selective Serotonin Reuptake Inhibitor Antidepressants on Their Cardiac Effects. Is There Any?
Authors: Pacher Pal , Ungvari Zoltan , Nanasi Peter  P. , Furst Susanna , Kecskemeti Valeria
Published: March 2022

The cardiovascular effects and toxicity of tricyclic antidepressants (TCAs) have been well documented in medical literature. The most common manifestation of such effects is slowing of intraventricular conduction, manifested by prolonged PR, QRS and QT intervals on the standard electrocardiogram (EGG) and postural hypotension. In contrast to TCAs, selective serotonin reuptake inhibitors (SSRis), including fluoxetine and citalopram, are considered to cause less effect on cardiac impulse conduction. In addition, these compounds induced significantly less anticholinergic, antihistaminergic and cardiotoxic side-effects than TCAs. However, there is an increasing number of case reports on dysrhythmias, like atrial fibrillation or bradycardia and syncope associated with fluoxetine and another SSRI treatment and overdose. Although such reports have not been common, they do raise concerns. In cardiac tissues isolated from canine, rabbit, rat and guinea pig hearts we have found that fluoxetine and
citalopram inhibited cardiac Na+ and Ca2+ channels. These direct cardiac electrophysiological
effects were similar to those of observed for tricyclic antidepressants clomipramine and imipramine. The inhibition of cardiac Ca2+ and Na+ channels by fluoxetine may explain most cardiac side-effects observed occasionally with the drug and mild but significant bradycardia reported during chronic treatment. Our results suggest that fluoxetine and citalopram may have antiarrhythmic (class I + IV type), as well as proarrhythmic properties (due to impairment of atrioventricular or intraventricular conduction and shortening of repolarization). Taking all these into consideration, in depressed patients having also severe cardiac disorders, EGG control may be suggested during fluoxetine and probable another SSRI therapy. The primary goal of this review is to compare these direct cardiac effects of fluoxetine and citalopram to those of previously reported for TCAs. This paper also summarizes the recently observed effects of fluoxetine apparently not related to the blockage of 5-HT transporter based on literature.
Melatonin
Authors: Marco Mor , Pier  Vincenzo Plazzi , Gilberto Spadoni , Giorgio Tarzia
Published: March 2022

Melatonin is the principal hormone secreted by the pineal gland, produced in humans with a circadian rhythm characterized by elevated blood
levels during the night. It is involved in the regulation of several rhythmic functions in various vertebrates, and participates in the processing of photoperiodic information. Although its role in human physiologic and pathologic processes is not yet completely understood, MLT exerts a number of actions, in physiological or pharmacological concentrations, which could be of interest for future therapeutic uses. The mechanisms involved in MLT actions include interaction with membrane receptors, recently classified as mt1/MT2/MT3, and with nuclear sites corresponding to orphan members of the nuclear receptor superfamily, RZR/ROR; MLT also acts as a radical scavenger, exerting a protective action against various oxidative injuries. The present review is mainly addressed to the medicinal chemistry of ligands at the MLT membrane receptors, focusing on the models of binding interaction published in the literature. Several different pharmacophore and 30-QSAR models have been reported so far, and a re­ consideration of known active compounds, in the light of the recently developed biological tests on cloned receptors, could help to resolve the incongruities among these models; to this end, additional information is becoming available from new, conformationally constrained ligands, and from antagonist compounds with a selective affinity for receptor subtypes.
Influence of the COVID-19 Pandemic on Clinical Trial Discontinuation in Anesthesiology: Cross-sectional Analysis
Authors: Traxler Brett D , Rucker Brayden M , Greenough Mary C , Sajjadi Nicholas B , Hartwell Micah
Published: March 2022

Background

The COVID-19 pandemic drastically altered perioperative medical practice owing to safety concerns, postponing elective or nonemergent procedures, supply chain shortages, and reallocating perioperative staff to care for patients with COVID-19. However, the impact of the pandemic on the conduct on anesthesiology clinical research is unknown.

Objective

The primary objective was to quantify the magnitude of the COVID-19 pandemic’s impact on anesthesiology clinical research.

Methods

We performed a systematic search using ClinicalTrials.gov to identify clinical trials related to the practice of anesthesiology. We screened trials with status updates from January 1, 2020, through October 1, 2021, to capture trials potentially affected by the COVID-19 pandemic by the time of our search. Investigators screened for relevant studies and extracted trial characteristics along with the reason for discontinuation reported on the clinical trial registry.

Results

A total of 823 clinical trials met inclusion criteria, and 146 clinical trials were discontinued within the designated date range. In total, 24 (16.4%) of the 146 clinical trials were halted explicitly owing to the COVID-19 pandemic. A significant association existed between trial enrollment numbers and the likelihood of discontinuation due to the COVID-19 pandemic, as larger trials were more likely to be disrupted (z=–2.914, P=.004).

Conclusions

The COVID-19 pandemic is reportedly associated with the discontinuation of anesthesiology-related clinical trials. With the uncertain course of the COVID-19 pandemic, developing anesthesia trial protocols to help minimize social interaction and prevent premature trial disruption are imperative.
Bioinformatics Analysis Uncovers the Importance of RTK-RAS-PI3K/Akt Regulation by Borneol in Overcoming Breast Cancer Resistance to Tamoxifen
Authors: Ali Zulfikar , Hermawan Adam
Published: March 2022

Currently, tamoxifen-based hormonal treatment remains the first line for luminal A (estrogen receptor [ER]-positive) subtype breast cancer, with a response of more than 30%. Chemoresistance was induced by the long-term use of tamoxifen therapy. Therefore, to prevent resistance and improve the effectiveness of tamoxifen, combined therapy is required. This study used bioinformatics to identify possible borneol target genes and their mechanism for overcoming tamoxifen resistance in breast cancer cells. We used data from the gene expression omnibus (GEO) collection to find differentially expressed genes (DEGs). The Database for Annotation, Visualization, and Integrated Discovery (DAVID) site, version 6.8, was also used to undertake gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis of the DEGs. The STRING-DB site, version 11.0, was used to predict protein-protein interaction (PPI) study. The PPI analysis findings were visualized using the Cytoscape software, version 3.8.2. The hub gene was further calculated using the CytoHubba plugin. The genomic alterations from the hub gene were evaluated using cBioPortal, version 1.18.1. The potential target genes (PTGs) of borneol compounds are ESR1, FGFR2, STAT3, ERBB4, PRKCA, and RTK-RAS PI3K-Akt signaling as its prospective mechanism to overcome tamoxifen resistance in breast cancer cells. More studies are needed to confirm the potential of borneol to overcome tamoxifen resistance in breast cancer.
Identification of Problems or Barriers in Medicine Procurement Process in Low- and Lower-Middle-Income Countries: A Narrative Review
Authors: Satibi Satibi , Faradiba Faradiba , Aditama Hardika , Dwi Prasetyo Septimawanto
Published: March 2022

Medicine procurement at LLMIC still becomes a challenge regarding to low medicine availability. There is no study yet that identifies the problems of medicine procurement at LLMIC countries so that it becomes the objective of this narrative review. PUBMED, Science Direct, Google Schoolar, PLOS from May 14th, 2021 to May 22nd, 2021 were used. The problems of procurement were found since the processes of selection, planning, and procurement. Factors of human resources, organization, management information system, and parties excluding health facilites (government, distributor, and pharmacy industry) also contribute to hinder the medicine procurement. The effort to solve this problem should include multisectors with the aim to strengthen the medicine management and the supply chain.

Keywords: supply chain, developing countries, medicine management
HPLC tracing of sennosides and quality control study of laxative herbal medicine “Al-Halol”
Authors: Aljameeli Ahmed , Ashour Mohamed
Published: March 2022

Al-Halol is a famous herbal recipe, formed of senna and supportive herbal remedies. It is distributed widely in the herbal markets of Saudi Arabia (KSA) and other Gulf countries. Al-Halol is prescribed for intestinal evacuation and treatment of different forms of constipation. The aim of the present study was to deal with the quality control (QC) status of three different formulations of “Al-Halol” (Lax-1, Lax-2 and Lax-3). A simple method was designed for isolation of crude sennosides fraction from standard senna leaves and utilized for HPLC tracing of sennosides in the tested herbal medicines along with several qualitative and quantitative QC tests. The present study revealed tentatively the presence of 3.6 % senna pods, 29.1% senna leaves and 22.6 % senna leaves as principle material in Lax-1, Lax-2 and Lax-3 respectively, percentage of intestinal motility in mice was also determined as 28.4%, 65.19% and 60.73% for Lax-1, Lax-2 and Lax-3 respectively compared with negative control (54.78%), and positive controls (i.e. senna leave extract = 81.2 %, and bisacodyl =76.7 %). There was a statistically significant difference between all groups (p value < 0.001), except between standard senna leaves extract and bisacodyl and between Lax-2 and Lax-3 extracts. However, great variations have been recorded between the different samples. The present work provides a simple method for isolation and HPLC tracing of sennosides in senna drugs. It is the first time for evaluation and QC study of these laxative herbal formulations.
Development of Warfarin Safety Monitoring System at Primary Health Care grounded on Chronic Care Model
Authors: Ploylearmsang Chanuttha , Poobal Peerapong , Kittiboonyakun Pattarin
Published: March 2022

Warfarin, an anticoagulant with high risk on the fatal adverse effects, the safety monitoring system in primary health care is needed for patients in the community.  This study aimed to investigate problems of warfarin use, to discover factors related to the blood clotting, and to develop a safety monitoring system for warfarin. A mixed method was conducted in two phases. Phase one consisted of home visit for 104 patients with warfarin which aimed to investigate use problems. Phase two; the focus groups included all stakeholders were done which aimed to develop a community-based system grounded on the Chronic Care Model (CCM). The warfarin monitoring system was implemented for a month and briefly evaluated the stakeholders’ satisfaction on it.  The results revealed that: Phase one, 38.5% patients with warfarin at home had missed their treatment appointments. Their warfarin compliance was 91.1+21.3%. 53.5% had unused warfarin at home; 37.4% had inappropriate warfarin storage; 13.1% suffered the side effect of minor bleeding; 17.3% potentially had warfarin-herb interactions; 61.3% experienced drug-warfarin interaction. Two factors significantly affecting on the International Normalized Ratio (INR) and %Time in Therapeutic Range (%TTR) were inappropriate warfarin dosages and taking other medications. %TTR was influenced by warfarin compliance. Stage two, the safety monitoring system and protocol were created using CCM. The developed system composed of six elements that were joint operation of primary health care personnel and inter-professional team of the hospital. This promoted the continuity of services from hospital to community.  After one-month implementation by an inter-professional team, all three groups of stakeholders were satisfied with its results. We concluded that the main problem afflicting warfarin patients was missed treatment appointments. Receiving extra medicines from other services, inappropriate dosage, and non-compliance. The developed warfarin monitoring system covered patients in primary health care, and all stakeholders were satisfied on its outcomes.
Da’wah in Household Product Advertisements: A Reception Study of Islamic Values in Nawaitu Sahaja TV Advertisements
Authors: Santoso Rahmania , Prianti Desi Dwi
Published: March 2022

In Indonesian contemporary society, spirituality and religion can be used to create Islamic brand identities. In order to promote the intended identity, marketers use advertisements to reach their target audience. Sahaja, an Indonesian brand of home care products, uses Islamic identity as part of their strategic communication. Using their Nawaitu Sahaja advertisements, they promote the da’wah (promotion of Islam) message. This research aimed to examine how a Muslim audience receives the Islamic da’wah used by Nawaitu Sahaja. To understand how audiences, receive the Islamic values portrayed in the Nawaitu Sahaja advertisements, seven women who are part of Nasyiatul Aisyiyah – an Islamic women’s organis ation – were interviewed in 2021. In order to promote their products, Nawaitu Sahaja advocates the importance of making a clean and hygienic home as part of one’s Islamic values. Baiti Jannati ("my home is my heaven") is the main message in these advertisements. Using Stuart Hall’s reception analysis, this research found different reading positions. Such reading positions were influenced by the audience's views on the message of Islamic values. Participants’ interpretations of the da’wah message in the Nawaitu Sahaja advertisements was found to be dominant. Using Islamic messages in advertisements is thus one way of engaging with consumers and encouraging them to purchase the products therein.
Post-War British Women Writers and their Cultural Impact: A Quantitative Approach
Authors: Berensmeyer Ingo , Trurnit Sonja
Published: March 2022

This article uses a quantitative approach to study the reception of women writers in post-war Britain. Using data from two influential journals in the period (1946–1960), the TLS and the Listener, we first establish a list of those contemporary British women writers who were most frequently mentioned in these magazines. We then compare their representation in the magazines to that of three comparison groups: a selection of British male contemporary writers, well-known earlier British women writers, and canonical male authors. We explore how the differential categories of gender and canonicity intersect in the (under ) representation of contemporary women writers, and how this underrepresentation not only holds true for the mid-twentieth century but, at least as it is reflected in the attention paid to writers by TLS reviewers, continues in the later 20th and early 21st century.
TEORIJA PRAVDE DŽONA ROLSA I (NE)POSTOJANJE ELEMENATA OVOG PRISTUPA U OBLIKOVANJU SISTEMA SOCIJALNE ZAŠTITE U DELU MATERIJALNE PODRŠKE GRAĐANIMA I GRAĐANKAMA REPUBLIKE SRBIJE
Authors: Jovanović Vladimir , Ivanović Angelina
Published: March 2022

Autori u tekstu polaze od analize jednog od najznačajnijih dela Džona Rolsa „Teorije pravde“, kao osnove za identifikaciju elemenata od značaja za sistem socijalne zaštite Republike Srbije, odnosno onog njegovog dela koji se odnosi na materijalne prestacije korisnicima. „Teorija pravde“ je imala duboke implikacije na oblikovanje mnogih sistema i njegovih delova, a naročito političkih teorija i političkih nauka. Ipak, implicitne i/ili eksplicitne efekte i uticaje ostvarila je i u oblikovanju onih delova javnih politika koje do sada nisu analizirane sa tog polaznog stanovišta, uključujući i sistem socijalne zaštite, odnosno pojedine delove ovog sistema. Stoga, predmet rada predstavlja analiza pristupa i efekata teorije pravde, koju uobličava Džon Rols u kontekstu socijalne zaštite Republike Srbije, odnosno onog dela sistema koji se odnosi na materijalnu podršku. Imajući u vidu predmet ovog rada, izveden je i cilj. A on se može odrediti kao analiza i identifikacija (ne)postojanja elemenata teorije pravde, onakve kakve je percipira pristup Džona Rolsa, u delu materijalne podrške građanima, kroz sistem socijalne zaštite.
Blockchain Based E-voting System Using Smart Contracts
Authors: Gajra Gautam , Ghadge Omkar , Gandhi Yash , Durge Prof. Devita
Published: March 2022

Abstract: Developing a protected electronic voting system that gives the decency and security of a current voting system, while providing the accuracy and flexibility offered by electronic systems, has been a test for quite a while. Use of blockchain as an assist to actualize disseminated digital balloting structures is accessed. At the present, neither civilians nor elected leaders have favoured conventional ballots. Elections are surrounded via way of means of vote falsification, bribery and different vote casting problems paper and polling shape balloting a ballot system, the checking of vote's takes hours and the number of the time days and hardly ever any activities reduce to rubble the effects through distinctive feature of human or machine. There needs to be an awesome function of current technology to improve the prevailing system. Blunder, which brings about the process taking much more. Blockchain innovation offers a fact in which that character flaw is eliminated from the situation and votes are checked proper away. Blockchain generation is the only one that handles the real vote. We use the stable hash set of rules for resolving this trouble and attempted to convey an answer via using this booming generation. The system based on blockchain will be safe, trustworthy, and private. It will help to realize the general remember of the applicants who participated and its capabilities inside the equal manner as people's religion of their governments does. The citizens and political selection executives can get sizable benefits from the voting poll programming application. And yet, e-vote casting a poll gives large risks to political race safety and honesty and modifications the concept of political selection straightforwardness and investigation. E-Voting has a Relatively bit of freedom; at the cease of the day, Relative Advantage is degree while an improvement is regarded as advanced to the past one; Since, e-Voting is advanced to the guide vote casting system. Keywords: Blockchain, E-voting, Security, Smart Contracts, Immutable
Study of Achievement Motivation of Sportsperson in Relation to their Pessimistic Attitudes
Authors: Malik Dr. Ishwar Singh , Meenu Dr.
Published: March 2022

Abstract:The study's goal was to look at sportspeople's achievement motivation in relation to their pessimistic attitudes. A total of 100 male athletes from various team sports were purposefully chosen to be the study's subjects. The individuals' ages ranged fro m 17 to 30, with the average age being 21 (+SD) years. Handball (20), Wushu (20), Cricket (20), Baseball (20), and Hockey (20) athletes with at least All India InterUniversity level participation in their respective sports disciplines were the subjects. To assess the attitude of Inter Varsity Sports person from different sports Pessimistic Attitude Scale (Parashar, 1998) was used. The collected data was analysed by computing Descriptive statistics, Independent t-test followed by Pearson’s Product moment correlation. The level of significance was set at 0.05 levels. Descriptive statistics, Independent ttest, and Pearson's Product Moment Correlation were used to analyse the collected data. The significance threshold was set at 0.05. Keywords: Achievement motivation, sports, participation.
Endophytes Associated with Macrophyte Ceratophyllum Demersum
Authors: S Nisy , N Vishnu , M Megha , C Amitha
Published: March 2022

Abstract: Endophytes are microorganisms living inside plants which have various types of symbiotic relations and non-symbiotic relations with host plant. The endophytes reside inside a plant without any signs or symptoms in living tissues of their host. Plants without any endophytes are rare, bacteria and fungi have been seen residing inside plants. Endophytes inside fossilized tissues and stems of plants indicates this relationship started during the evolution or formation of higher plants. The Bacterial and fungal endophytes reach the plant tissues from the rhizosphere, phyllosphere or seed of the plant. Endophytes of Ceratophyllum demersum, were isolated by two methods. Endophytic bacteria and fungi were found to reside in the leaves of macrophyte Ceratophyllum demersum. Four fungal isolates and three bacterial isolates were obtained. Results indicates that fungal endophytes were predominant than bacterial endophytes in Ceratophyllum demersum. Keywords: Ceratophyllum demersum, Macrophytes, Endophytic Bacteria, Endophytic Fungi.
ANALYSIS, PRACTICAL APPLICATION AND POSSIBLE INTERCONNECTION OF INDUSTRIAL ENGINEERING METHODS AND KEY PERFORMANCE INDICATORS
Authors: Marecek-Kolibisky Martin , Brlej Tomas , Kucerova Marta
Published: March 2022

In connection with applying the principles of Industry 4.0, the industrial practice also requires the consistent application of industrial engineering methods to improve process performance. The transformation of society into digital affects almost all areas of industry, public administration, healthcare and all walks of life. The implementation of Industry 4.0 is very important in the automotive, engineering and electrical engineering industries. It is the move towards Industry 4.0, the collection of large amounts of data and the decision-making based on the data obtained that provide the ideal basis for using more complex industrial engineering methods and better process evaluation. The paper's main goal is to analyse and identify the use of industrial engineering methods and key performance indicators of companies in industrial practice in Slovakia, where practice shows a lower acquaintance with these methods, especially among medium-sized companies. The paper deals with the issue of industrial engineering methods aimed at improving process performance in the context of key performance indicators. The paper contains some results of a questionnaire survey aimed at gathering information on improvement methods and identifying the use of key performance indicators in industrial practice. Which results will bring us closer to which types of methods are most used in Slovak practice and why?
Comparing science communication theory with participatory practice: case study of the Australian Climate Champion Program
Authors: Metcalfe Jennifer
Published: March 2022

While short-term participatory science communication activities have been well researched, long-term programs have received scant attention. Analysing survey data and participant discussions, I investigated interactions between Australian farmers and scientists engaged in the Climate Champion Program (2009–2016). I compared their interactions to three theorised science communication models: deficit, dialogue and participatory. I found their interactions illustrated a mix of the characteristics of all three models. While farmers and scientists appeared to be motivated to interact by deficit and dialogue objectives, respectful and trusting relationships emerged from long-term participation, which was key to making deficit- and dialogue-style communication more effective.
The Group Provisory Conclusion, a powerful tool for science debut
Authors: Hvass-Faivre d'Arcier Marima
Published: March 2022

This article will take you through the evolution of our approach in presenting and communicating science. For twenty years ‘1, 2, 3, sciences’ has run participatory live workshops for adults. A special tool, the Group Provisory Conclusion or GPC, involving each participant, contributes to the success. Our expectation was to rekindle the public’s interest through participatory methods, supported by the emergence of collective intelligence. It describes our actions to help people reduce their apprehension towards science.
Participatory science communication for transformation
Authors: Metcalfe Jennifer , Gascoigne Toss , Medvecky Fabien , Nepote Ana Claudia
Published: March 2022

Participatory science communication featured in several sessions and individual papers at the 2021 online conference of the Public Communication of Science and Technology (PCST) Network. This coverage recognises the drive away from linear communication to more participatory forms of science communication. In this special edition we present practice insights, papers and essays that explore participatory science communication. These contributions explore definitions, processes and describe case-studies of participatory science communication which involve a variety of publics, from young school students to Indigenous groups to farmers. In this introductory editorial we reflect on the papers, describe the growth of a participatory approach as part of the continuing evolution of science communication; explore a definition for participatory science communication; and consider some of the key concepts and issues that emerged.
For real-world outcomes you need real-world training: participatory capacity building in science communication
Authors: Walker Graham
Published: March 2022

Concepts underpinning participatory science communication have much to offer science communication training and capacity building. This paper investigates a capacity building program with 15 science communicators from nine African countries involved in a six-week program in Australia. Data was collected via surveys, observations, informal interactions and ongoing relationships tracking program outcomes. Key features with a participatory nature included: holistic programs giving participants diverse skills and entry points; ensuring participant's freedom, agency, autonomy and self-efficacy; real-world networking as a self-directed participatory process; participant-led design processes to build skills for creating programs; and, embedding training in real-world contexts with deliberately selected publics.
Hemi-Slant Submanifold of (LCS)n-Manifold
Authors: Karmakar Payel , Bhattacharyya Arindam
Published: March 2022

In this paper we analyse briefly some properties of hemi-slant sub-manifold of (LCS)n-manifold. Here we discuss about some necessary and sufficient conditions for distributions to be integrable and obtain some results in this direction. We also study the geometry of leaves of hemi-slant submanifold of (LCS)n-manifold. At last we give an example of a hemi-slant submanifold of an (LCS)n-manifold.
Analisis sektor unggulan perekonomian Provinsi Jambi
Authors: Novriansyah Bambang , Tan Syamsurijal , Rosmeli Rosmeli
Published: March 2022

This study identifies the leading sectors in the regional economy of Jambi Province and the share and growth of these top sectors. This study uses secondary data in monographs from the Central Statistics Agency of Jambi Province. The analytical method used is Location Quotient (LQ) and Klassen Typology analysis and use quantitative analysis. Based on the results of the research shows that the leading sectors in Jambi Province are the Agriculture, Forestry and Fisheries sectors, Government Administration, Defense, and Social Security sectors, Construction sector, Real Estate sector, Educational Services sector, Wholesale and Retail Trade sector, Car and Motorcycle Repair, Sector Information and Communication, Health and Insurance Services sector, and Other Services sector. Meanwhile, the fast growth and significant contribution share is the Agriculture, Forestry and Fisheries sector and the Food and Drink Accommodation Provision sector.
Responses of CO 2 emission to external organic carbon input in the drying-rewetting cycles: a meta-analysis
Authors: Lin Junjie , Dong Hongxin , Liu Dan , Wang Kehong , Yu Zhiguo , kumar Amit
Published: March 2022

In recent decades, global warming under rising CO
significantly influences external organic carbon (EOC) input and
drying-rewetting processes in terrestrial ecosystems. However, little is
known about how soil CO emissions respond to these
perturbations, which provides us with a chance to explore potential
factors and variability. In this study, a meta-analysis on the responses
of CO emissions with or without EOC input in the soil
drying-rewetting cycles (DWC) based on 291 observations (included 33
study sites and 11 variables) has been conducted. The results indicated
that i) CO emission with the increase of EOC by 284%
relative to without EOC under DWC; ii) The effect size of CO
emission was the smallest in the forest (+15%) and
the largest in the grassland (+1468%); iii) The CO
emission effect sizes were substantially greater in complex substrates
(+288%) than in simple substrates (+132%), and iv) longer drought
period in a DWC can induce more CO emission. The study
suggests that terrestrial CO emission may be multi
folds in the long drought-rapid rewetting processes under large input of
EOC.
COVID-19 vaccine-associated myositis -- a case report.
Authors: Bose Ponnu , Goenka Usha , Moitra Saibal , Majumdar Sanjib , Goenka Mahesh , Sen Srijita
Published: March 2022

Myositis is one of the uncommon adverse events following COVID–19
vaccination, and its mechanism is still unclear. In the hope of aiding
in its better understanding, we present a case of myositis following the
first dose of the ChAdOx1 nCoV-19 Corona Virus Vaccine, evidenced by
serology and MRI.
Self-reported beta-lactam allergy: inpatients in government funded and privately funded hospitals Cape Town, South Africa
Authors: Day Cascia , Deetlefs M. , O’Brien A. , Smith J. , Boyd M. , Embling N. , Patel S. , Moody K. , Ramabele T. , Budge A. , Tarwa Tapiwa Tavarwisa , Jim O. , Maharaj T. , Pandy S. , Abrahams JM. , Panieri A. , Verhage S. , Merwe M. van der , Geragotellis A. , Amanjee W. , Joseph C. , Zhao Z. , Moosa S. , Bunting M. , Pulani Yanelisa , Mukhari P. , Paiva M. de , Deyi G. , Wonkam R. Peigou , Mancotywa N. , Dunge A. , Msimanga T. , Singh A. , Monnaruri O. , Molale B. , Butler T. , Browde K. , Muller C. , Walt J. Van Der , Whitelaw R. , Cronwright D. , Parker N. , Sinha S. , Binase U. , Francis I. , Boakye D. , Dlamini S. , Mendelson M. , PETER Jonny
Published: March 2022

Background Up to a quarter of inpatients in high-income
countries self-report beta-lactam allergy (BLA), which if incorrect, can
increase use of alternative antibiotics that impact on bacterial
resistance.. The epidemiology of BLA in low- and middle-income African
countries is unknown. Methods Point-prevalence surveys were
conducted at seven hospitals (adult, pediatric, government and
private-funded, district- and tertiary-level) in Cape Town, South Africa
between April 2019 and June 2021. Ward prescription records and
interviews were conducted to identify BLA patients. De-labeling was
attempted at the tertiary allergy clinic at Groote Schuur hospital.
Findings A total of 1486 hospital inpatients were surveyed
(1166 adults; 308 children). Only 48 (3.2%) patients self-reported a
BLA with a higher rate amongst private- versus government-funded
hospitals [6.3% vs 2.8%, p=0.014]. Using the PEN-FAST tool, only
10.4% (5/48) of self reported BLA patients were classified as high risk
for true penicillin hypersensitivity. Antibiotics were prescribed to
70.8% (34/48) of self reported BLA patients, with 64.7% (22/34)
receiving a beta-lactam. Despite three attempts to contact patients for
de-labelling at the allergy clinic, only 3/36 underwent in vivo testing,
with no positive results and one patient proceeded toa negative oral
challenge. Interpretation Unlike high-income countries,
self-reported BLA is low amongst inpatients in South Africa. The
majority of self-reported BLA were low risk for type 1 hypersensitivity,
but out-patient de-labeling efforts were largely unsuccessful.
Funding None
Stability Analysis on Daphnia Population Model with Size-Structured and Delayed Birth Process
Authors: Hu Dandan , Huang Gang
Published: March 2022

In this paper, we investigate a size-structured population dynamics
model of Daphnia coupled with an unstructured algal food source, where
there is a maturation delay in the birth process. Our research focuses
on the stability properties of stationary solutions, especially the
impact of maturation delay on the asymptotic behavior of system. The
existence of the stationary solutions are discussed, and the linear
stability results under some biologically conditions are investigated by
means of the semigroup theory and the characteristic equation technique.
Numerical simulations are performed to verify the theoretical results
and display the different impacts of delay in several examples.
A Pediatric Case of Severe Vitamin B12 Deficiency Presenting as Transaminitis
Authors: Sanchez Josue , Zheng Yingying , Lee Brittany , Whitfield Andrea , Feerick John
Published: March 2022

The classic findings of vitamin B12 deficiency include anemia and
neurologic symptoms. Elevation of liver enzymes is an atypical finding
of this deficiency. In this case report, we present a ten-year-old male
with pancytopenia due to vitamin B12 deficiency which was associated
with elevated transaminases. Extensive work-up was completed to find a
cause for this transaminitis with unremarkable results. Liver enzyme
levels normalized with aggressive intramuscular vitamin B12
supplementation, suggesting a direct correlation.
Numerical scheme of fractional differential-integral equations in three-dimensional spaces via block-pulse functions
Authors: Shi Wei , Huang Qingxue , Xie Jiaquan , Wang Tao
Published: March 2022

In the current study, an effective numerical technique is presented for
solving a class of three-dimensional fractional differential-integral
equations via the three-dimensional block-pulse functions. The Caputo
fractional derivative is applied to deal with the fractional derivative
terms, and the differential operational matrices of 3D-BPFs are utilized
to transform the original system. In the end of the paper, two numerical
examples are presented to verify the proposed method.
Qualitative Analysis of Stochastically Perturbed HIV Model
Authors: Senthilkumaran M. , Ponmari K.
Published: March 2022

The dynamical behavior of a perturbed Human Immunodeficiency Virus (HIV)
model is investigated in this paper. We first determine a positively
invariant set in which the perturbed system admits a unique, positive,
global solution. Following that, we discuss the stability of
infection-free equilibrium of the deterministic model. We also obtain
the conditions required for the p th -moment
exponential stability, for the perturbed system. Later we show that if
R >1 for smaller intensity of noise, the
solution of stochastic system oscillates around E.
Our results demonstrate that a large value of noise suppresses the
disease from persistence exponentially. We also derive the condition for
the persistence of the disease. Finally, comparison of our analytical
results with simulations is to be done.
Liquid-Vapor Two-Phase Flow in Centrifugal Pump: Cavitation, Mass Transfer, and Impeller Structure Optimization
Authors: Li Gaoyang , Ding Xuhui , Wu Yubin , Wang Sirui , Li Dong , Yu Wenjin , Wang Xuezheng , Zhu Yonghong , Guo Yuting
Published: March 2022

Computational fluid dynamics (CFD) has been widely used to model the
internal flow field of centrifugal pumps to analyze cavitation
phenomena. However, accurate determination of cavitation in pumps
remains a challenge. In this study, liquid-vapor two-phase flow in
centrifugal pump at different conditions and impeller structural
parameters were studied numerically and experimentally. Cavitation
multiphase unsteady model was proposed to simulate the flow field in the
centrifugal pump by CFD method, and an experimental platform was set up
to obtain cavitation performance results. The simulation data were
validated with experiment and good consistency was achieved. This study
investigated the mass transfer and cavitation behavior of centrifugal
pumps under various conditions and customizes a simulation process to
obtain the optimal combination of impeller blade number, blade wrap
angle, and blade installation angle, which was expected to provide
helpful insights into the structural optimization design of centrifugal
pumps with good cavitation resistance.
Stable isotope analysis of plant water and soil water across two vegetation types in the northern Qinghai-Tibet Plateau
Authors: Li Jing , Zhang Fawei , Du Yangong , WANG Yunying , Lan Yuting , Fan Bo , Zhou H , wang Bin , Cao Guangmin , Guo Xiaowei
Published: March 2022

Studying the interrelation of soil water and plant water is essential
for an in-depth understanding of eco-hydrological processes. However,
water use relationships and comparative studies between shrubs and
alpine grassland of the northern Qinghai-Tibet Plateau remain poorly
understood. In this study, we compared δ18O and δ2H values of water from
soil, plant, precipitation, and groundwater between P. fruticosa shrub
and alpine grassland locations at two neighboring sites in order to
better understand the interface between plant and surrounding soils of
shrubs and grasslands in the northern Qinghai-Tibet Plateau. Our results
showed that δ18O and δ2H of soil water, precipitation, and plant water
varied significantly over time and water sources in P. fruticosa shrub
and alpine grassland sites. Both soil evaporation and plant
transpiration at the P. fruticosa shrub site were relatively lower than
they were at the alpine grassland site. Alpine grassland plant water had
a stronger dynamic fractionation effect in the process of transportation
and was more sensitive to environmental conditions. However, plants at
the P. fruticosa shrub site displayed more flexible water use patterns,
shifted their water sources between shallow soil water and deep soil
water. Shrubs from alpine grassland leaded to changes in grassland water
use, thereby changing soil water storage. The results of this study will
provide theoretical basis for improving the availability and
sustainability of soil water, provide guidance for meadow management
from ecohydrological processes on the northern Qinghai-Tibet Plateau.
Exotic dynamics of freak waves governed by the focusing Kundu-Eckhaus equation
Authors: Wang Xiu-Bin , Tian Shoufu
Published: March 2022

In this work, general higher-order freak wave solutions of the focusing
Kundu-Eckhaus equation can be calculated theoretically through a Darboux
transformation by a separation of variable method. Moreover, the
dynamics of first-order and second-order freak wave solutions are
discussed with some graphics. In particular, we observe that one
four-petaled freak wave and three eye-shaped ones can coexist, in
contrast to the four eye-shaped ones reported before. They demonstrate
that the structure of freak waves in this paper is richer than that in
the well-known NLS equation.
New solitary wave solutions for the perturbed Gerdjikov-Ivanov equation.
Authors: Li Hang
Published: March 2022

In this research, through the calculation of nonlinear algebraic systems
by Maple software, the powerful direct truncation method is applied to
construct the solutions to a significant nonlinear mathematical physical
model in nonlinear optics, namely, the perturbed Gerdjikov-Ivanov
equation. We successfully obtain some new solitary wave solutions,
including bright, dark, kink soliton and periodic solutions.
Furthermore, we discuss the relationships between the types of solutions
and the coefficients of the perturbed and non-perturbed terms. To
present the physical features of our interesing results, the 2D and 3D
shapes of representative solutions are plotted under the appropriate
selection of parameter values. The acquired results are of significance
to the dynamics of soliton propagation through optical fibers.
Cough and Protracted Bacterial Bronchitis (PBB) in Children Analytic View
Authors: CORTES PABLO
Published: March 2022

The evolution of the concept of PBB is analyzed over time since it
appeared as protracted bronchitis1, later protracted bacterial
bronchitis (PBB)2, and finally its “clinical” version3, which avoids
the need to perform fiberoptic bronchoscopy in children. However, this
deviates in a significant manner from the principle on which the concept
is based, giving rise to the idea of a disease that only affects
children with the main characteristic of bacteriological isolation from
lower airways. On the other hand, the clinical diagnosis of PBB is made
by excluding other diseases through so-called “pointers to specific
cough (primarily for chronic cough)”1 with a posterior reference of
signs and symptoms called specific cough pointers2 and finally, in 2020,
“Pointers to presence of specific cough”.4 Comments are then made on
how asthma (and early wheezing) and posterior nasal drip syndrome are
ruled out as important causes of chronic and recurrent cough in
children. In conclusion, the causes of acute and chronic cough in
children, with a few exceptions, are quite comparable to the causes of
cough in adults. Therefore, an easy and more accurate way of diagnosing
cough in children could be to reconsider our concepts of so-called cough
pointers, upper airway cough syndrome, and asthma (and early wheezing)
in children.
Optic Pathway tumor in a novel KIAA1109 variant
Authors: Shah Krunal , Sanghavi Niyati , Viswanathan Aarthi , Kumar Arun , Kumar Nuthan , Kaushik Prakruthi , Kumari BS Aruna , L Appaji
Published: March 2022

Alkuraya-Kucinskas syndrome is a neurodevelopmental disorder due to
mutation in KIAA1109 gene. We report a case of optic pathway tumor in a
child with novel variant of KIAA1109. A plausible mechanism of
gliomagenesis is considered based on influence of KIAA1109 on regulation
of phosphatidyl inositol phosphorylation.
Rapid detection of porcine encephalomyocarditis virus (EMCV) by isothermal reverse transcription recombinase polymerase amplification assays
Authors: Jianchang Wang , Wang Jinfeng , Chen Sinan , Han Qingan , Wang Kairui , Liu Libing , Xu Xiangdong , Yuan Wanzhe
Published: March 2022

Reverse transcription recombinase polymerase amplification assays
combined with the fluorescence detection platform (qRT-RPA) and lateral
flow biosensor (LFB RT-RPA) were developed and validated for rapid
detection of porcine EMCV. The primers and probes were designed based on
the highly conserved region of 3D gene of porcine EMCV. The optimal
reaction condition of qRT-RPA and LFB RT-RPA assay was at 42 °C for 20
min. The assays were highly specific to EMCV and no cross-reactions were
observed with other 7 porcine viruses. With the 10-fold sieral diluted
EMCV genomic RNA as template, the limit of detection of the qRT-RPA
assay was 1.0×10 copies and the limit of detection
of LFB RT-RPA was 1.0×10 copies. A total of 92
samples collected from EMCV inoculated mice (24), control mice (8) and
pigs showing reproductive failures (60) were examined using developed
RT-RPA and a described qRT-PCR, and the diagnostic agreement between
qRT-RPA (23/92), LFB RT-RPA (25/92) and qRT-PCR (23/92) was 100% and
97.83, respectively. The performances of the developed RT-RPA assays
were comparable to a qRT-PCR, while the RPA assays needed less time and
easy to perform to obtain the positive results and LFB RT-RPA was higher
sensitive than the qRT-PCR. The developed EMCV RT-RPA assays are rapid,
reliable and easy to perform, which provide an attractive and promising
tool for effective detection of EMCV in low-resource settings.
Nutraceuticals in India: Past, present and likely future
Authors: Malve Harshad
Published: March 2022

Nutraceuticals are gaining importance owing to the increasing focus on
overall health due to recent pandemic. Nutraceuticals include products
which help in maintaining immunity and prevent diseases. It also
includes products which support the optimal functioning of the human
body. Poor nutrition plays an important role in non-communicable
diseases and lifestyle-related disorders as well. Hence it has
significant impact on overall public health. Various nutraceuticals have
exhibited therapeutic potential and hence gained popularity.
Nutraceuticals are mainly categorized into dietary supplements and
functional foods. With multiple factors contributing to the growth of
nutraceuticals industry in India, we are marching towards global
leadership in nutraceuticals. Food Safety and Standards Authority of
India is solely responsible for regulating the approval, promotions, and
labeling standards for health supplements and nutraceuticals. As the
understanding of these nutritional products is improving, the
regulations are becoming more specific. There is a need to monitor the
usage of such nutritional products regularly and stringently.
Nutrivigilance and phytovigilance are relatively new concepts in our
country; however, regulatory authorities need to proactively observe for
the undesirable, unintended effects and issues related to substandard
and counterfeit nutraceutical products. Healthcare professionals
including pharmaceutical physicians and public health professionals can
play an important role in safeguarding the population by advocating
rational use of nutraceuticals, food supplements, and consumer health
products.