STUDY OF THE PROTECTIVE EFFECT OF THE FEED ADDITIVE «PHYTODOC NEURO» WITH THE COMBINED INTAKE OF LEAD AND CADMIUM INTO THE BODY OF WHITE RATS
Authors:   All-Russian Research Institute for Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow 123022, Russian Federation, Pavlova Natalia S. , Pavlenko Galina I. ,   All-Russian Research Institute for Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow 123022, Russian Federation, Drozdov Dmitry A. ,   All-Russian Research Institute for Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow 123022, Russian Federation, Brichko Natalya A. ,   All-Russian Research Institute for Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow 123022, Russian Federation, Dorozhkin Vasily I. ,   All-Russian Research Institute for Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow 123022, Russian Federation, Zakharova Lyubov L. ,   All-Russian Research Institute for Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow 123022, Russian Federation
Published: April 2024

Feed additives containing biologically active substances are used more to neutralize the negative effects of various toxicants, stress, age-related changes in the brain, and also to increase the cognitive abilities of animals. Substances involved in metabolism and activating defense mechanisms are of great interest. As a means to reduce the negative effects of chronic intake of cadmium and lead, the functional feed additive «Phytodoc neuro» was taken, which contains glycine, vitamin E, lecithin and carnitine base as active ingredients. The effectiveness of the feed additive «Phytodoc neuro» at a dose of 4 g/kg of feed as a means to reduce cadmium and lead intoxication when they were simultaneously supplied in doses of 5 and 50 mg/kg of feed, respectively, in terms of metal was studied. With alimentary intake of cadmium and lead in animals, the content of hemoglobin and erythrocytes in peripheral blood significantly decreased, the neutralizing function of the liver was disrupted, there was a clear trend towards a decrease in horizontal and vertical working capacity, body weight, immunoglobulin levels and the number of SH groups in blood serum. The use of the FA «Phytodoc neuro» led to the normalization of all the changed indicators.