bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 1 from CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression
Authors: Wang Yunshan , Wen Mingxin , Kwon Yongwon , Xu Yangyang , Liu Yueyong , Zhang Pengju , He Xiuquan , Wang Qin , Huang Yurong , Jen Kuang-Yu , LaBarge Mark A. , You Liang , Kogan Scott C. , Gray Joe W. , Mao Jian-Hua , Wei Guangwei
Published: March 2023

PDF file - 198K, Supplemental Figure 1. CUL4A promotes proliferation of human mammary epithelial and BC cells.
Supplementary Tables 1 - 2 from Identification of Immune Factors Regulating Antitumor Immunity Using Polymeric Vaccines with Multiple Adjuvants
Authors: Ali Omar A. , Verbeke Catia , Johnson Chris , Sands R. Warren , Lewin Sarah A. , White Des , Doherty Edward , Dranoff Glenn , Mooney David J.
Published: March 2023

PDF file - 237KB, Vaccine induction of inflammatory cytokine production at the vaccine site (S1); The correlation between local cytokine concentration and survival outcome in vaccinated mice (S2).
Supplementary Figure 2 from MYC Synergizes with Activated BRAFV600E in Mouse Lung Tumor Development by Suppressing Senescence
Authors: Tabor Vedrana , Bocci Matteo , Alikhani Nyosha , Kuiper Raoul , Larsson Lars-Gunnar
Published: March 2023

PDF file - 152K, Analysis of senescence, apoptosis and p19Arf expression in lung tissues of BRAF/MYC mice.
Supplementary Figure 6 from Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway
Authors: Martín-Pérez Rosa , Palacios Carmen , Yerbes Rosario , Cano-González Ana , Iglesias-Serret Daniel , Gil Joan , Reginato Mauricio J. , López-Rivas Abelardo
Published: March 2023

PDF file - 23KB, TRAIL-independent induction of apoptosis upon ER stress.
Supplementary Figure 1 from Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway
Authors: Martín-Pérez Rosa , Palacios Carmen , Yerbes Rosario , Cano-González Ana , Iglesias-Serret Daniel , Gil Joan , Reginato Mauricio J. , López-Rivas Abelardo
Published: March 2023

PDF file - 154KB, Enhanced sensitivity of mutant ERBB2-expressing breast epithelial cells to ER stress.
Supplementary Methods from Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive Neuroblastoma
Authors: Barbieri Eveline , De Preter Katleen , Capasso Mario , Chen Zaowen , Hsu Danielle M. , Tonini Gian Paolo , Lefever Steve , Hicks John , Versteeg Rogier , Pession Andrea , Speleman Frank , Kim Eugene S. , Shohet Jason M.
Published: March 2023

PDF file - 36K
Supplementary Figure 3 from Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive Neuroblastoma
Authors: Barbieri Eveline , De Preter Katleen , Capasso Mario , Chen Zaowen , Hsu Danielle M. , Tonini Gian Paolo , Lefever Steve , Hicks John , Versteeg Rogier , Pession Andrea , Speleman Frank , Kim Eugene S. , Shohet Jason M.
Published: March 2023

PDF file - 57K, In vitro effects of CHAF1A silencing on proliferation.
Supplementary Figures 1 - 4 from p53-Induced miR-15a/16-1 and AP4 Form a Double-Negative Feedback Loop to Regulate Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Shi Lei , Jackstadt Rene , Siemens Helge , Li Huihui , Kirchner Thomas , Hermeking Heiko
Published: March 2023

PDF file - 519K, Supplementary Figure 1 Western blot analysis of AP4 protein expression in SW480 cells after transfection of the indicated siRNA for 48 hours. Supplementary Figure 2 In silico analysis of the 3�-UTR of EMT transcription factors. Supplementary Figure 3 Ectopic AP4 overcomes a G1-cell cycle arrest induced by miR-15a/16-1. Supplementary Figure 4 Cell proliferation of SW620-Luc2 cells
Supplementary Methods, Figures 1 - 6, Tables 1 - 5 from Identification of a Tumor-Suppressive Human-Specific MicroRNA within the FHIT Tumor-Suppressor Gene
Authors: Hu Baocheng , Ying Xiaomin , Wang Jian , Piriyapongsa Jittima , Jordan I. King , Sheng Jipo , Yu Fang , Zhao Po , Li Yazhuo , Wang Hongyan , Ng Wooi Loon , Hu Shuofeng , Wang Xiang , Wang Chenguang , Zheng Xiaofei , Li Wuju , Curran Walter J. , Wang Ya
Published: March 2023

PDF file - 858KB, Supplementary Methods, Supplementary References, Figure S1-6, Table S1-5. Figure S1. Identification of a new miR in FHIT intron. Figure S2. The SNP variant around the Pri-C2-miR region in FHIT did not affect the C2-miR expression. Figure S3. C2-miR and FHIT are under the same transcriptional control. Figure S4. C2-miR inhibiting human tumor cell growth was not through promoting apoptosis. Figure S5. C2-miR inhibits human tumor cell growth through targeting CCND1, ERBB2, DNMT3A or DNMT3B. Figure S6. Multiple members of the miR-548 family could target the same oncogenes. Table S1. The documented miR-548 family members. Table S2. Quantities of FHIT or C2-miR in total cell RNA (20 ng). Table S3. Expression comparison of pri-miRs or mature miRs in 293FT cells. Table S4. Primers used in this study. Table S5. NanoString probes for detecting 29 members of the miR-548 family.
Supplementary Figures 1 - 10 from LEF1 and B9L Shield β-Catenin from Inactivation by Axin, Desensitizing Colorectal Cancer Cells to Tankyrase Inhibitors
Authors: de la Roche Marc , Ibrahim Ashraf E.K. , Mieszczanek Juliusz , Bienz Mariann
Published: March 2023

PDF file - 4151K, Fig S1 Molecular targets of beta-catenin inhibitors. Fig S2 Efficacy and toxicity of beta-catenin inhibitors. Fig S3 Effects of TNKSi on Wnt signaling components. Fig S4 TNKSi-induced Axin degradasomes. Fig S5 TNKSi treatment of COLO320 cells. Fig S6 Prolonged TNKSi treatment and beta-catenin stability. Fig S7 TNKSi of chronically Wnt-stimulated HeLa cells. Fig S8 TNKSi responses of Wnt-stimulated cells. Fig S9 CA treatment of mice. Fig S10 Comparison of LEF1 antibodies.
Supplementary Figure 2 from Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging
Authors: Allen Michael D. , Luong Phuong , Hudson Chantelle , Leyton Julius , Delage Barbara , Ghazaly Essam , Cutts Rosalind , Yuan Ming , Syed Nelofer , Lo Nigro Cristiana , Lattanzio Laura , Chmielewska-Kassassir Malgorzata , Tomlinson Ian , Roylance Rebecca , Whitaker Hayley C. , Warren Anne Y. , Neal David , Frezza Christian , Beltran Luis , Jones Louise J. , Chelala Claude , Wu Bor-Wen , Bomalaski John S. , Jackson Robert C. , Lu Yong-Jie , Crook Tim , Lemoine Nicholas R. , Mather Stephen , Foster Julie , Sosabowski Jane , Avril Norbert , Li Chien-Feng , Szlosarek Peter W.
Published: March 2023

PDF file - 802K, Metabolomics of ADI-PEG20 in a corroborative cell line panel (mesothelioma).
Supplementary Figure 1 from Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging
Authors: Allen Michael D. , Luong Phuong , Hudson Chantelle , Leyton Julius , Delage Barbara , Ghazaly Essam , Cutts Rosalind , Yuan Ming , Syed Nelofer , Lo Nigro Cristiana , Lattanzio Laura , Chmielewska-Kassassir Malgorzata , Tomlinson Ian , Roylance Rebecca , Whitaker Hayley C. , Warren Anne Y. , Neal David , Frezza Christian , Beltran Luis , Jones Louise J. , Chelala Claude , Wu Bor-Wen , Bomalaski John S. , Jackson Robert C. , Lu Yong-Jie , Crook Tim , Lemoine Nicholas R. , Mather Stephen , Foster Julie , Sosabowski Jane , Avril Norbert , Li Chien-Feng , Szlosarek Peter W.
Published: March 2023

PDF file - 408K, Pyrosequencing data of bladder cancer cell lines and primary bladder cancer samples.
Supplementary Table 8 from LRH-1 Governs Vital Transcriptional Programs in Endocrine-Sensitive and -Resistant Breast Cancer Cells
Authors: Bianco Stéphanie , Brunelle Mylène , Jangal Maïka , Magnani Luca , Gévry Nicolas
Published: March 2023

PDF file - 33KB, Table S8. Overexpressed gene signature Oncomine.
Supplementary Figure 2 from p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis
Authors: Zhong Jian , Ding Liya , Bohrer Laura R. , Pan Yunqian , Liu Ping , Zhang Jun , Sebo Thomas J. , Karnes R. Jeffrey , Tindall Donald J. , van Deursen Jan , Huang Haojie
Published: March 2023

PDF file - 207KB, Histological (hematoxylin and eosin) analysis of anterior prostate (AP) and dorsolateral prostate (DLP) of 4-month-old Ptenpc-/- and Ptenpc-/-;p300pc-/- mice (n = 8/genotype).
Supplementary Figure Legends, Figures 1 - 8, Tables 1 - 7 from LRH-1 Governs Vital Transcriptional Programs in Endocrine-Sensitive and -Resistant Breast Cancer Cells
Authors: Bianco Stéphanie , Brunelle Mylène , Jangal Maïka , Magnani Luca , Gévry Nicolas
Published: March 2023

PDF file - 1103KB, Figure S1. ERalpha expression in HMEC, MCF7, LCC2 and LCC9 cells. Figure S2. LRH-1 depletion using shRNA in MCF7 and AE-resistant cell lines. Figure S3. LRH-1 ChIP-seq validation. Figure S4. Med12 signal associated with LRH-1 binding events presenting low FAIRE and H3K27ac signal. Figure S5. Integration of ChIP-seq and ChIA-PET profile of LRH-1 target genes. Figure S6. Integration of ChIP-seq and ChIA-PET profile of LRH-1 target genes. Figure S7. LRH-1 inhibition decreases cellular growth. Figure S8. CCND1 expression following anti-estrogen treatment. Table S1. List of shRNA against LRH-1. Table S2. List of primers used for mRNA analysis. Table S3. List of antibodies used in ChIP and WB. Table S4. List of primers used for ChIP analysis. Table S5. Transcriptional profile of LRH-1 depleted MCF7 cells. Table S6. Transcriptional profile of LRH-1 depleted LCC2 cells. Table S7. Transcriptional profile of LRH-1 depleted LCC9 cells.
Supplementary Table 1 from Small Molecule Agonists of PPAR-γ Exert Therapeutic Effects in Esophageal Cancer
Authors: Sawayama Hiroshi , Ishimoto Takatsugu , Watanabe Masayuki , Yoshida Naoya , Sugihara Hidetaka , Kurashige Junji , Hirashima Kotaro , Iwatsuki Masaaki , Baba Yoshifumi , Oki Eiji , Morita Masaru , Shiose Yoshinobu , Baba Hideo
Published: March 2023

PDF file - 120K, Clinical or pathological feature according to PPARγ expression.
Supplementary Figures 1 - 9 from Small Molecule Agonists of PPAR-γ Exert Therapeutic Effects in Esophageal Cancer
Authors: Sawayama Hiroshi , Ishimoto Takatsugu , Watanabe Masayuki , Yoshida Naoya , Sugihara Hidetaka , Kurashige Junji , Hirashima Kotaro , Iwatsuki Masaaki , Baba Yoshifumi , Oki Eiji , Morita Masaru , Shiose Yoshinobu , Baba Hideo
Published: March 2023

PDF file - 818K, The study design for selecting the ESCC patients (S1); TE-4 cells were transfected with PPARG siRNA (S2); In vitro anti-proliferative effects of efatutazone (S3); Anti-proliferative effects of efatutazone in ESCC cells occur via pAkt-p21Cip1 (S4); In vivo anti-proliferative effects of efatutazone (S5); Investigation using condition medium (S6); EGFR/MAPK signaling activation (S7); Anti-proliferative effects of molecule targeted therapy (S8); The primers and probes used for real time RT-PCR (S9).
Supplementary Figure 6 from Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Authors: Meeker Stacey , Seamons Audrey , Paik Jisun , Treuting Piper M. , Brabb Thea , Grady William M. , Maggio-Price Lillian
Published: March 2023

PDF file - 60K, Helicobacter colonization is not altered by increased dietary vitamin D.
Supplementary Figure 3 from Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Authors: Meeker Stacey , Seamons Audrey , Paik Jisun , Treuting Piper M. , Brabb Thea , Grady William M. , Maggio-Price Lillian
Published: March 2023

PDF file - 100K, Increased dietary vitamin D decreases inflammation in H. bilis-infected Smad3-/- mice.
Supplementary Figure 3 from Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling
Authors: Schroeder Anne , Herrmann Andreas , Cherryholmes Gregory , Kowolik Claudia , Buettner Ralf , Pal Sumanta , Yu Hua , Müller-Newen Gerhard , Jove Richard
Published: March 2023

PDF file - 2401K, Supplementary Fig. 3: Characterization of recombinant IL-6RFP.
Supplementary Table 1 from CD133+ Cancer Stem-like Cells in Small Cell Lung Cancer Are Highly Tumorigenic and Chemoresistant but Sensitive to a Novel Neuropeptide Antagonist
Authors: Sarvi Sana , Mackinnon Alison C. , Avlonitis Nicolaos , Bradley Mark , Rintoul Robert C. , Rassl Doris M. , Wang Wei , Forbes Stuart J. , Gregory Christopher D. , Sethi Tariq
Published: March 2023

PDF file - 82KB, IC50 values in uM of H345 and H69 cells treated with substance-P analogues.
Supplementary Figure 3 from VISTA Regulates the Development of Protective Antitumor Immunity
Authors: Le Mercier Isabelle , Chen Wenna , Lines Janet L. , Day Maria , Li Jiannan , Sergent Petra , Noelle Randolph J. , Wang Li
Published: March 2023

PDF file - 75K, The distinct population of myeloid-derived suppressor cells (MDSCs) infiltrating the B16 melanoma and MB49 bladder tumors.
Supplementary Figure 5 from Survival in Patients with High-Risk Prostate Cancer Is Predicted by miR-221, Which Regulates Proliferation, Apoptosis, and Invasion of Prostate Cancer Cells by Inhibiting IRF2 and SOCS3
Authors: Kneitz Burkhard , Krebs Markus , Kalogirou Charis , Schubert Maria , Joniau Steven , van Poppel Hein , Lerut Evelyne , Kneitz Susanne , Scholz Claus Jürgen , Ströbel Philipp , Gessler Manfred , Riedmiller Hubertus , Spahn Martin
Published: March 2023

PDF file - 61K, Interferon signaling pathway and Enriched pathways based on lists of down-regulated or up-regulated genes.
Supplementary Figure 4 from Survival in Patients with High-Risk Prostate Cancer Is Predicted by miR-221, Which Regulates Proliferation, Apoptosis, and Invasion of Prostate Cancer Cells by Inhibiting IRF2 and SOCS3
Authors: Kneitz Burkhard , Krebs Markus , Kalogirou Charis , Schubert Maria , Joniau Steven , van Poppel Hein , Lerut Evelyne , Kneitz Susanne , Scholz Claus Jürgen , Ströbel Philipp , Gessler Manfred , Riedmiller Hubertus , Spahn Martin
Published: March 2023

PDF file - 33K, Upregulation of miR-221 in pre miR-221 transfected cell lines.
Supplementary Figure 7 from Metastatic Consequences of Immune Escape from NK Cell Cytotoxicity by Human Breast Cancer Stem Cells
Authors: Wang Bin , Wang Qiang , Wang Zhe , Jiang Jun , Yu Shi-Cang , Ping Yi-Fang , Yang Jing , Xu Sen-Lin , Ye Xian-Zong , Xu Chuan , Yang Lang , Qian Cheng , Wang Ji Ming , Cui You-Hong , Zhang Xia , Bian Xiu-Wu
Published: March 2023

The effect of ATRA on the sensitivity to NK cell killing, survival, and lung metastasis of BCSCs
Supplementary Figure 6 from FANCJ Localization by Mismatch Repair Is Vital to Maintain Genomic Integrity after UV Irradiation
Authors: Guillemette Shawna , Branagan Amy , Peng Min , Dhruva Aashana , Schärer Orlando D. , Cantor Sharon B.
Published: March 2023

PDF file - 106K, Supplemental Figure 6. FANCJ deficient cells are sensitive to DNA interstrand crosslinking agents and FANCJ suppresses UV-induced mutations
Supplementary Figure 2 from Metastatic Consequences of Immune Escape from NK Cell Cytotoxicity by Human Breast Cancer Stem Cells
Authors: Wang Bin , Wang Qiang , Wang Zhe , Jiang Jun , Yu Shi-Cang , Ping Yi-Fang , Yang Jing , Xu Sen-Lin , Ye Xian-Zong , Xu Chuan , Yang Lang , Qian Cheng , Wang Ji Ming , Cui You-Hong , Zhang Xia , Bian Xiu-Wu
Published: March 2023

Activation and cytotoxicity of NK cells by interaction with BCSCs or non-BCSCs.
Supplementary Figure 1 from Metastatic Consequences of Immune Escape from NK Cell Cytotoxicity by Human Breast Cancer Stem Cells
Authors: Wang Bin , Wang Qiang , Wang Zhe , Jiang Jun , Yu Shi-Cang , Ping Yi-Fang , Yang Jing , Xu Sen-Lin , Ye Xian-Zong , Xu Chuan , Yang Lang , Qian Cheng , Wang Ji Ming , Cui You-Hong , Zhang Xia , Bian Xiu-Wu
Published: March 2023

Characterization of stem-like properties of ALDH+ cells isolated from primary breast cancer specimens.
Supplementary Figure 4 from GPR56 Inhibits Melanoma Growth by Internalizing and Degrading Its Ligand TG2
Authors: Yang Liquan , Friedland Scott , Corson Nancy , Xu Lei
Published: March 2023

PDF file - 16K, This figure shows the effects of TG2 on melanoma metastasis.
Supplementary Table 1 from Vemurafenib Cooperates with HPV to Promote Initiation of Cutaneous Tumors
Authors: Holderfield Matthew , Lorenzana Edward , Weisburd Ben , Lomovasky Lisa , Boussemart Lise , Lacroix Ludovic , Tomasic Gorana , Favre Michel , Vagner Stephan , Robert Caroline , Ghoddusi Majid , Daniel Dylan , Pryer Nancy , McCormick Frank , Stuart Darrin
Published: March 2023

PDF file - 50K, RAS mutation and HPV status of cutaneous lesions by histological type.
Supplementary Methods, Figures 1 - 3 from Sequential Application of a Cytotoxic Nanoparticle and a PI3K Inhibitor Enhances Antitumor Efficacy
Authors: Pandey Ambarish , Kulkarni Ashish , Roy Bhaskar , Goldman Aaron , Sarangi Sasmit , Sengupta Poulomi , Phipps Colin , Kopparam Jawahar , Oh Michael , Basu Sudipta , Kohandel Mohammad , Sengupta Shiladitya
Published: March 2023

PDF file - 251K, Fig. 1S: Depiction of drug model for nanoparticle release and delayed transmembrane transport of self-assembling cis-platinum nanoparticles (SACNs) and free cisplatin in an acidic environment. Fig. 2S: Flowchart showing the computational algorithm used to fit parameters in the mathematical model. Fig. 3S: (Data points) The release profile of cisplatin nanoparticles was evaluated at 37 degrees C in neutral and acidic (tumor like) pH in triplicates.
Supplementary Figure 1 from Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2
Authors: Lopez-Rivera Esther , Jayaraman Padmini , Parikh Falguni , Davies Michael A. , Ekmekcioglu Suhendan , Izadmehr Sudeh , Milton Denái R. , Chipuk Jerry E. , Grimm Elizabeth A. , Estrada Yeriel , Aguirre-Ghiso Julio , Sikora Andrew G.
Published: March 2023

PDF file - 132K, Mel 624 (A) and MeWo cells (B) were transfected with iNOS-specific or scrambled control siRNA and inoculated on the CAM for 5 days prior to photography of macroscopic tumors, histological processing, and trypan exclusion viability assay as described in Figure 1. Each graph represents data derived from 2 independent experiments, and error bars indicate standard error of the mean.
Supplementary Tables 1 - 3, Figures 1 - 7 from An Antibody–Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors
Authors: Breij Esther C.W. , de Goeij Bart E.C.G. , Verploegen Sandra , Schuurhuis Danita H. , Amirkhosravi Ali , Francis John , Miller Vibeke Breinholt , Houtkamp Mischa , Bleeker Wim K. , Satijn David , Parren Paul W.H.I.
Published: March 2023

PDF file - 166K, Supplementary Table S1: TF HuMab: target binding characteristics and inhibition of FXa generation. Supplementary Table S2: Cross-competition between TF HuMab. Supplementary Table S3: Thromboelastography: coagulation of LPS-stimulated whole blood in the presence of 20 microg/mL TF-011, TF-013 or TF-098. Supplementary Figure S1: TF HuMab inhibit TF:FVIIa-induced ERK1/2 phosphorylation. Supplementary Figure S2: TF:FVIIa-induced IL-8 production in MDA-MB-231 cells is reduced in the presence of TF HuMab. Supplementary Figure S3: Binding of TF HuMab is unaltered after conjugation with vcMMAE or mcMMAF. Supplementary Figure S4: Anti-tumor activity of TF-ADCs in the A431 and HCT-116 xenograft models. Supplementary Figure S5: Anti-tumor activity of unconjugated TF HuMab in vivo. Supplementary Figure S6: Post-paclitaxel treatment with TF-011-MMAE in PDX models. Supplementary Figure S7: Full-length blots for Figure 1C.
Supplementary Figures 1 - 7 from Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma
Authors: Yan Fengting , Alinari Lapo , Lustberg Mark E. , Katherine Martin Ludmila , Cordero-Nieves Hector M. , Banasavadi-Siddegowda Yeshavanth , Virk Selene , Barnholtz-Sloan Jill , Bell Erica Hlavin , Wojton Jeffrey , Jacob Naduparambil K. , Chakravarti Arnab , Nowicki Michal O. , Wu Xin , Lapalombella Rosa , Datta Jharna , Yu Bo , Gordon Kate , Haseley Amy , Patton John T. , Smith Porsha L. , Ryu John , Zhang Xiaoli , Mo Xiaokui , Marcucci Guido , Nuovo Gerard , Kwon Chang-Hyuk , Byrd John C. , Chiocca E. Antonio , Li Chenglong , Sif Said , Jacob Samson , Lawler Sean , Kaur Balveen , Baiocchi Robert A.
Published: March 2023

PDF file - 1690KB, Supplemental Figure S1. PRMT5 is over-expressed in human GBM cell lines. Supplemental Figure S2: High grade astrocytomas Supplemental Figure S3: efficacy and specificity of PRMT5 knock-down by lead siRNA. Supplemental Figure S4: PRMT5 Knockdown promotes cell death of human GBM cells Supplemental Figure S5: si-PRMT5 induced cell death is P53-independent Supplemental Figure S6: Decreased ST7 expression correlates with worse survival in all glioma patients (grade I-IV). Supplemental Figure S7: Over-expression of ST7 in three GBM cell lines was confirmed by real-time PCR and western blot (top panels).
Supplementary Figure 5 from Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation
Authors: Lallet-Daher Hélène , Wiel Clotilde , Gitenay Delphine , Navaratnam Naveenan , Augert Arnaud , Le Calvé Benjamin , Verbeke Stéphanie , Carling David , Aubert Sébastien , Vindrieux David , Bernard David
Published: March 2023

PDF - 5961KB, KCNA1 localization is regulated by PKA.
Supplementary Figure 4 from Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation
Authors: Lallet-Daher Hélène , Wiel Clotilde , Gitenay Delphine , Navaratnam Naveenan , Augert Arnaud , Le Calvé Benjamin , Verbeke Stéphanie , Carling David , Aubert Sébastien , Vindrieux David , Bernard David
Published: March 2023

PDF - 3282K, Membrane-associated KCNA1 favors OIS hallmarks.
Supplementary Figure 7 from NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells
Authors: Kottakis Filippos , Foltopoulou Parthena , Sanidas Ioannis , Keller Patricia , Wronski Ania , Dake Benjamin T. , Ezell Scott A. , Shen Zhu , Naber Stephen P. , Hinds Philip W. , McNiel Elizabeth , Kuperwasser Charlotte , Tsichlis Philip N.
Published: March 2023

PDF file - 3801KB, The knockdown of NDY1/KDM2B is not rescued by exogenous EZH2.
Supplementary Figure 4 from Activation of the NOTCH Pathway in Head and Neck Cancer
Authors: Sun Wenyue , Gaykalova Daria A. , Ochs Michael F. , Mambo Elizabeth , Arnaoutakis Demetri , Liu Yan , Loyo Myriam , Agrawal Nishant , Howard Jason , Li Ryan , Ahn Sun , Fertig Elana , Sidransky David , Houghton Jeffery , Buddavarapu Kalyan , Sanford Tiffany , Choudhary Ashish , Darden Will , Adai Alex , Latham Gary , Bishop Justin , Sharma Rajni , Westra William H. , Hennessey Patrick , Chung Christine H. , Califano Joseph A.
Published: March 2023

PDF file - 82K, Growth effects of NOTCH1 siRNA inhibition in HNSCC cells with wildtype NOTCH1 status. NOTCH1 was downregulated in UPCI-SCC090 (090, top, NOTCH1 wt) and SCC61 (bottom, NOTCH1 wt) by siRNA as described in methods. The effect of NOTCH1 downregulation on cell proliferation for these two cell lines is shown in the middle. The effect of siNOTCH1 on NOTCH1 expression (left) or expression of its targets (HES1 and HEY1, right) is also shown. The mRNA expression levels were calculated relative to GAPDH and were normalized to 1 in the control experiments with scrambled siRNA sequences. Experiments were performed in pentaplicates, mean plus-minus SEM were shown. *, p-value < 0.05.
Supplementary Figure 4 from HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2
Authors: Cheng Guangcun , Sun Xueqing , Wang Jinglong , Xiao Gang , Wang Xiumin , Fan Xuemei , Zu Lidong , Hao Mingang , Qu Qing , Mao Yan , Xue Yunjing , Wang Jianhua
Published: March 2023

PDF file - 77K, LCN2 does not affect MMP9 expression.
Supplementary Figure 3 from HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2
Authors: Cheng Guangcun , Sun Xueqing , Wang Jinglong , Xiao Gang , Wang Xiumin , Fan Xuemei , Zu Lidong , Hao Mingang , Qu Qing , Mao Yan , Xue Yunjing , Wang Jianhua
Published: March 2023

PDF file - 141K, HIC1 and LCN2 do not affect epithelial-mesenchymal transition (EMT).
Supplementary Figure 3 from Acquired Expression of NFATc1 Downregulates E-Cadherin and Promotes Cancer Cell Invasion
Authors: Oikawa Tsukasa , Nakamura Atsuko , Onishi Nobuyuki , Yamada Taketo , Matsuo Koichi , Saya Hideyuki
Published: March 2023

PDF file, 821K, NFATc1 directly activates SNAI1 transcription.
Dataset S2 from The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development
Authors: Venkateswaran Amudhan , Sekhar Konjeti R. , Levic Daniel S. , Melville David B. , Clark Travis A. , Rybski Witold M. , Walsh Alexandra J. , Skala Melissa C. , Crooks Peter A. , Knapik Ela W. , Freeman Michael L.
Published: March 2023

XLSX file 47K, Down-regulated genes assigned to GO:0008152 metabolic processing
Supplementary Figure 5 from RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma
Authors: Lam Adeline R. , Le Bert Nina , Ho Samantha S.W. , Shen Yu J. , Tang Melissa L.F. , Xiong Gordon M. , Croxford J. Ludovic , Koo Christine X. , Ishii Ken J. , Akira Shizuo , Raulet David H. , Gasser Stephan
Published: March 2023

PDF file - 555K, Stainings of cytosolic DNA in Ara-C-treated BC2 cells and Yac-1 cells.
Supplementary Table 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Authors: Kim Jae-Hwan , Sharma Amrish , Dhar Shilpa S. , Lee Sung-Hun , Gu Bingnan , Chan Chia-Hsin , Lin Hui-Kuan , Lee Min Gyu
Published: March 2023

PDF file - 61KB, Statistically significant Gene Ontology (GO) terms of genes co- downregulated by UTX and MLL4 knockdown.
Supplementary Figure Legend from CRR9/CLPTM1L Regulates Cell Survival Signaling and Is Required for Ras Transformation and Lung Tumorigenesis
Authors: James Michael A. , Vikis Haris G. , Tate Everett , Rymaszewski Amy L. , You Ming
Published: March 2023

PDF file - 47K
Supplementary Figure 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Authors: Kim Jae-Hwan , Sharma Amrish , Dhar Shilpa S. , Lee Sung-Hun , Gu Bingnan , Chan Chia-Hsin , Lin Hui-Kuan , Lee Min Gyu
Published: March 2023

PDF file - 33KB, UTX or MLL4 knockdown reduced expression levels of MMP-9, MMP-11, Six1, Cyclin A1, and CSPG4 genes in MDA-MB-468 cells.
Supplementary Figure 5 from CRR9/CLPTM1L Regulates Cell Survival Signaling and Is Required for Ras Transformation and Lung Tumorigenesis
Authors: James Michael A. , Vikis Haris G. , Tate Everett , Rymaszewski Amy L. , You Ming
Published: March 2023

PDF file - 92K, TERT Depletion in Mouse Cells.
Supplementary Methods, Figure Legend from Identification of a Cyclin D1 Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint
Authors: Ju Xiaoming , Casimiro Mathew C. , Gormley Michael , Meng Hui , Jiao Xuanmao , Katiyar Sanjay , Crosariol Marco , Chen Ke , Wang Min , Quong Andrew A. , Lisanti Michael P. , Ertel Adam , Pestell Richard G.
Published: March 2023

PDF file - 124K
Supplementary Figure 3 from Identification of a Cyclin D1 Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint
Authors: Ju Xiaoming , Casimiro Mathew C. , Gormley Michael , Meng Hui , Jiao Xuanmao , Katiyar Sanjay , Crosariol Marco , Chen Ke , Wang Min , Quong Andrew A. , Lisanti Michael P. , Ertel Adam , Pestell Richard G.
Published: March 2023

PDF file - 208K, DHT regulated gene pathways in cyclin D1+/+ and cyclin D1-/- mouse prostates.
Supplementary Methods and Figures Legends from Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells
Authors: Satelli Arun , Mitra Abhisek , Cutrera Jeffry J. , Devarie Marcos , Xia Xueqing , Ingram Davis R. , Dibra Denada , Somaiah Neeta , Torres Keila E. , Ravi Vinod , Ludwig Joseph A. , Kleinerman Eugenie S. , Li Shulin
Published: March 2023

PDF file - 120KB
Supplementary Table 3 from YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway
Authors: Zhao Yulei , Khanal Prem , Savage Paul , She Yi-Min , Cyr Terry D. , Yang Xiaolong
Published: March 2023

PDF file - 52KB, Antibodies used in present study.
Supplementary Movie Legends from Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer
Authors: Thadani-Mulero Maria , Portella Luigi , Sun Shihua , Sung Matthew , Matov Alexandre , Vessella Robert L. , Corey Eva , Nanus David M. , Plymate Stephen R. , Giannakakou Paraskevi
Published: March 2023

PDF file - 58KB
Supplementary Table 2 from YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway
Authors: Zhao Yulei , Khanal Prem , Savage Paul , She Yi-Min , Cyr Terry D. , Yang Xiaolong
Published: March 2023

PDF file - 30KB, siRNA and shRNA sequences.
Supplemental Figure S4 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: March 2023

A, Western blot analyses showing expression of AZIN1 protein in the indicated cell lines. beta-actin was the loading control. B, Quantification of cells from the indicated cells that migrated through the PET-membrane or invaded through the Matrigel-coated membrane.
Supplemental Figure S3 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: March 2023

The total mRNA levels of AZIN1 (left panel) and FLNB (right panel) in 69 matched pairs of ESCC and NT specimens in Cohort 1 (Paired Student's t test).
Supplementary Video 1 from miR-28-5p Promotes Chromosomal Instability in VHL-Associated Cancers by Inhibiting Mad2 Translation
Authors: Hell Michael P. , Thoma Claudio R. , Fankhauser Niklaus , Christinat Yann , Weber Thomas C. , Krek Wilhelm
Published: March 2023

MOV file - 701KB, Suppl. Movie 1: Analysis of nocodazole-induced mitotic arrest in HeLa cells. Time-lapse (5 min interval, total time: 14h) movies of nocodazole-arrested HeLa H2B-GFP cells transfected with siCtrl.
Supplementary FIgure legends from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: March 2023

Supplementary Figure legends
Supplementary FIgure S7 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: March 2023

Figure. S7. blocking AR signaling could inhibit AR positive cell migration, invasion and proliferation in a concentration-dependent in vivo and in vitro.
Supplementary Table 2 from CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells
Authors: Lau Wen Min , Teng Eileen , Chong Hui Shan , Lopez Kirsten Anne Pagaduan , Tay Amy Yuh Ling , Salto-Tellez Manuel , Shabbir Asim , So Jimmy Bok Yan , Chan Shing Leng
Published: March 2023

PDF file - 25KB, Supplementary Table S2 shows estimation of CSC frequency in unsorted, EpCAM+CD133+ and EpCAM+CD133- fractions from GC16 xenografts.
Supplementary Data 6 from Circadian Regulation of mTOR by the Ubiquitin Pathway in Renal Cell Carcinoma
Authors: Okazaki Hiroyuki , Matsunaga Naoya , Fujioka Takashi , Okazaki Fumiyasu , Akagawa Yui , Tsurudome Yuuya , Ono Mayumi , Kuwano Michihiko , Koyanagi Satoru , Ohdo Shigehiro
Published: March 2023

PDF file - 105K, Influence of everolimus dosing time on mTOR signal activity.
Supplementary Figure 2 from CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells
Authors: Lau Wen Min , Teng Eileen , Chong Hui Shan , Lopez Kirsten Anne Pagaduan , Tay Amy Yuh Ling , Salto-Tellez Manuel , Shabbir Asim , So Jimmy Bok Yan , Chan Shing Leng
Published: March 2023

PDF file - 126KB, Supplementary Figure S2 shows characterization of CD44v8-10 antibody by flow cytometry and gating strategy and isotype control for Figure 3.
Supplementary Data 2 from Circadian Regulation of mTOR by the Ubiquitin Pathway in Renal Cell Carcinoma
Authors: Okazaki Hiroyuki , Matsunaga Naoya , Fujioka Takashi , Okazaki Fumiyasu , Akagawa Yui , Tsurudome Yuuya , Ono Mayumi , Kuwano Michihiko , Koyanagi Satoru , Ohdo Shigehiro
Published: March 2023

PDF file - 49K, Sequences of primers used for RT-PCR analysis.
Supplementary Figure 1 from CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells
Authors: Lau Wen Min , Teng Eileen , Chong Hui Shan , Lopez Kirsten Anne Pagaduan , Tay Amy Yuh Ling , Salto-Tellez Manuel , Shabbir Asim , So Jimmy Bok Yan , Chan Shing Leng
Published: March 2023

PDF file - 118KB, Supplementary Figure S1 shows gating strategies for flow cytometry, quantitation for EpCAM expression level and EpCAM+ cells initiated tumors in mice.
Supplementary Table 1 from IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Authors: Ma Shoubao , Cheng Qiao , Cai Yifeng , Gong Huanle , Wu Yan , Yu Xiao , Shi Liyun , Wu Depei , Dong Chen , Liu Haiyan
Published: March 2023

PDF file - 45KB, Primers for RT-PCR and real-time PCR
Supplementary Figure 8 from IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Authors: Ma Shoubao , Cheng Qiao , Cai Yifeng , Gong Huanle , Wu Yan , Yu Xiao , Shi Liyun , Wu Depei , Dong Chen , Liu Haiyan
Published: March 2023

PDF file - 69KB, MDSCs promote the differentiation of IL-17 producing gammadelta T cells without selectivity on Vgamma4+ gammadelta T cells in vitro.
Supplementary Figure 1 from IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Authors: Ma Shoubao , Cheng Qiao , Cai Yifeng , Gong Huanle , Wu Yan , Yu Xiao , Shi Liyun , Wu Depei , Dong Chen , Liu Haiyan
Published: March 2023

PDF file - 348KB, IL-17A does not affect tumor cell viability and apoptosis in vitro, but affects CTL response in vivo.
Supplementary Figure 3 from A Sequence Polymorphism in miR-608 Predicts Recurrence after Radiotherapy for Nasopharyngeal Carcinoma
Authors: Zheng Jian , Deng Jieqiong , Xiao Mang , Yang Lei , Zhang Liyuan , You Yonghe , Hu Min , Li Na , Wu Hongchun , Li Wei , Lu Jiachun , Zhou Yifeng
Published: March 2023

PDF file - 1147K, The miR-608 expression levels in NPC cells after lentivirus infection. Data are mean plus-minus SEM, normalized to U6.
Supplementary Materials and Methods, Figures 1 - 5 from E3 Ubiquitin Ligase HOIP Attenuates Apoptotic Cell Death Induced by Cisplatin
Authors: MacKay Craig , Carroll Eilís , Ibrahim Adel F.M. , Garg Amit , Inman Gareth J. , Hay Ronald T. , Alpi Arno F.
Published: March 2023

PDF file - 1462KB, Fig. S1: HOIP depletion results in cisplatin hypersensitivity. Fig. S2: HOIP depletion sensitizes cells to genotoxin-induced apoptotic cell death. Fig. S3: HEK293 cells stably expressing HA-IκBα S32A;S36A. Fig. S4: Boxplot analysis of the mRNA expression levels of HOIP and SHARPIN in cisplatin sensitive and resistant cell lines. Fig. S5: Boxplot analysis of the mRNA expression levels of HOIP and SHARPIN in ovarian serous carcinoma tumour samples.
Supplementary Figure 5 from Overexpression of the Transcription Factor MEF2D in Hepatocellular Carcinoma Sustains Malignant Character by Suppressing G2–M Transition Genes
Authors: Ma Leina , Liu Jia , Liu Limei , Duan Guangjie , Wang Qingliang , Xu Yanmin , Xia Feng , Shan Juanjuan , Shen Junjie , Yang Zhi , Bie Ping , Cui Youhong , Bian Xiu-Wu , Prieto Jesus , Avila Matías A. , Qian Cheng
Published: March 2023

PDF file - 637K, Supplementary Figures S5: The representative flow plots for cell cycle analysis.
Supplementary Materials from Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
Authors: Nagathihalli Nagaraj S. , Beesetty Yugandhar , Lee Wooin , Washington M. Kay , Chen Xi , Lockhart A. Craig , Merchant Nipun B.
Published: March 2023

PDF file - 66KB
Supplementary Figure 2 from Overexpression of the Transcription Factor MEF2D in Hepatocellular Carcinoma Sustains Malignant Character by Suppressing G2–M Transition Genes
Authors: Ma Leina , Liu Jia , Liu Limei , Duan Guangjie , Wang Qingliang , Xu Yanmin , Xia Feng , Shan Juanjuan , Shen Junjie , Yang Zhi , Bie Ping , Cui Youhong , Bian Xiu-Wu , Prieto Jesus , Avila Matías A. , Qian Cheng
Published: March 2023

PDF file - 156K, Supplementary Figures S2: Expression and function of MEF2D in HCC cells.
Supplementary Figure 9 from Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
Authors: Nagathihalli Nagaraj S. , Beesetty Yugandhar , Lee Wooin , Washington M. Kay , Chen Xi , Lockhart A. Craig , Merchant Nipun B.
Published: March 2023

PDF file - 57KB, Schematic model showing the mechanism.
Supplementary Figure S5 from 5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell–like Cells in Acute Myeloid Leukemia
Authors: Roos Jessica , Oancea Claudia , Heinssmann Maria , Khan Dilawar , Held Hannelore , Kahnt Astrid S. , Capelo Ricardo , la Buscató Estel , Proschak Ewgenij , Puccetti Elena , Steinhilber Dieter , Fleming Ingrid , Maier Thorsten J. , Ruthardt Martin
Published: March 2023

Direct interaction of 5-LO with β-catenin.
Supplementary Figure 1 from Cyclin E1 Deregulation Occurs Early in Secretory Cell Transformation to Promote Formation of Fallopian Tube–Derived High-Grade Serous Ovarian Cancers
Authors: Karst Alison M. , Jones Paul M. , Vena Natalie , Ligon Azra H. , Liu Joyce F. , Hirsch Michelle S. , Etemadmoghadam Dariush , Bowtell David D.L. , Drapkin Ronny
Published: March 2023

PDF file - 198K, Full-length Western blots corresponding to Fig. 4A.
Supplementary Figure 3 from The CXCL7/CXCR1/2 Axis Is a Key Driver in the Growth of Clear Cell Renal Cell Carcinoma
Authors: Grépin Renaud , Guyot Mélanie , Giuliano Sandy , Boncompagni Marina , Ambrosetti Damien , Chamorey Emmanuel , Scoazec Jean-Yves , Negrier Sylvie , Simonnet Hélène , Pagès Gilles
Published: March 2023

PDF file - 431K, Anti-CXCL7 antibodies induce tumor necrosis.
Supplementary Table 3 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Authors: Gomez German G. , Volinia Stefano , Croce Carlo M. , Zanca Ciro , Li Ming , Emnett Ryan , Gutmann David H. , Brennan Cameron W. , Furnari Frank B. , Cavenee Webster K.
Published: March 2023

PDF file - 85KB, The intersection of CLIP-seq data with miR-9 target sites predicted by TargetScan and PicTar yielded a list of putative miR-9 targets.
Supplementary Table 1 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Authors: Gomez German G. , Volinia Stefano , Croce Carlo M. , Zanca Ciro , Li Ming , Emnett Ryan , Gutmann David H. , Brennan Cameron W. , Furnari Frank B. , Cavenee Webster K.
Published: March 2023

PDF file - 62KB, MiRs differentially expressed in 4 human glioma cell lines.
Supplementary Figure Legend from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Authors: Skrypnyk Nataliya , Chen Xiwu , Hu Wen , Su Yan , Mont Stacey , Yang Shilin , Gangadhariah Mahesha , Wei Shouzuo , Falck John R. , Jat Jawahar Lal , Zent Roy , Capdevila Jorge H. , Pozzi Ambra
Published: March 2023

PDF file - 68K
Supplementary Figure 6 from Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay
Authors: MacArthur Kelly M. , Kao Gary D. , Chandrasekaran Sanjay , Alonso-Basanta Michelle , Chapman Christina , Lustig Robert A. , Wileyto E. Paul , Hahn Stephen M. , Dorsey Jay F.
Published: March 2023

PDF file - 43KB, Supplementary Figure 6. Glioma CTCs show lack of EpCAM expression.
Supplementary Figure 3 from Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay
Authors: MacArthur Kelly M. , Kao Gary D. , Chandrasekaran Sanjay , Alonso-Basanta Michelle , Chapman Christina , Lustig Robert A. , Wileyto E. Paul , Hahn Stephen M. , Dorsey Jay F.
Published: March 2023

PDF file - 68KB, Supplementary Figure 3. Verification of the specificity of Anti-EGFR antibody.
Supplementary Figure 4 from miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 Pathway
Authors: Zhao Jian-Jun , Lin Jianhong , Zhu Di , Wang Xujun , Brooks Daniel , Chen Ming , Chu Zhang-Bo , Takada Kohichi , Ciccarelli Bryan , Admin Samir , Tao Jianguo , Tai Yu-Tzu , Treon Steven , Pinkus Geraldine , Kuo Winston Patrick , Hideshima Teru , Bouxsein Mary , Munshi Nikhil , Anderson Kenneth , Carrasco Ruben
Published: March 2023

PDF file - 2071KB, MiR-30s treatment does not have a negative impact on bone disease in MM1S-Luc-Neo bearing mice.
Data Supplement from High-Throughput Time-Resolved FRET Reveals Akt/PKB Activation as a Poor Prognostic Marker in Breast Cancer
Authors: Veeriah Selvaraju , Leboucher Pierre , de Naurois Julien , Jethwa Nirmal , Nye Emma , Bunting Tamara , Stone Richard , Stamp Gordon , Calleja Véronique , Jeffrey Stefanie S. , Parker Peter J. , Larijani Banafshé
Published: March 2023

Supplementary Figure Legends
Supplementary Figure Legend from The DREAM Complex Mediates GIST Cell Quiescence and Is a Novel Therapeutic Target to Enhance Imatinib-Induced Apoptosis
Authors: Boichuk Sergei , Parry Joshua A. , Makielski Kathleen R. , Litovchick Larisa , Baron Julianne L. , Zewe James P. , Wozniak Agnieszka , Mehalek Keith R. , Korzeniewski Nina , Seneviratne Danushka S. , Schöffski Patrick , Debiec-Rychter Maria , DeCaprio James A. , Duensing Anette
Published: March 2023

PDF file - 70K
Supplementary Figure 3 from The DREAM Complex Mediates GIST Cell Quiescence and Is a Novel Therapeutic Target to Enhance Imatinib-Induced Apoptosis
Authors: Boichuk Sergei , Parry Joshua A. , Makielski Kathleen R. , Litovchick Larisa , Baron Julianne L. , Zewe James P. , Wozniak Agnieszka , Mehalek Keith R. , Korzeniewski Nina , Seneviratne Danushka S. , Schöffski Patrick , Debiec-Rychter Maria , DeCaprio James A. , Duensing Anette
Published: March 2023

PDF file - 4178K, Supplemental Figure 3. Imatinib treatment does not induce a senescence phenotype.
Supplementary Table 6 from Genetic and Phenotypic Diversity in Breast Tumor Metastases
Authors: Almendro Vanessa , Kim Hee Jung , Cheng Yu-Kang , Gönen Mithat , Itzkovitz Shalev , Argani Pedram , van Oudenaarden Alexander , Sukumar Saraswati , Michor Franziska , Polyak Kornelia
Published: March 2023

XLSX file - 107K, Shannon and Simpson's index for each cell type based on BAC, CEP, BAC/CEP and unique counts.
Data Supplement from Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development
Authors: Giammanco Antonina , Blanc Valerie , Montenegro Grace , Klos Coen , Xie Yan , Kennedy Susan , Luo Jianyang , Chang Sung-Hee , Hla Timothy , Nalbantoglu ILKe , Dharmarajan Sekhar , Davidson Nicholas O.
Published: March 2023

Supplemental Figure S3. mRNA expression of apoptosis-related factors in AOM-DSS-treated Hur IKO and Hur f/f mice.
Supplementary Table 1 from Function-Blocking ERBB3 Antibody Inhibits the Adaptive Response to RAF Inhibitor
Authors: Kugel Curtis H. , Hartsough Edward J. , Davies Michael A. , Setiady Yulius Y. , Aplin Andrew E.
Published: March 2023

PDF file - 98K, 1205 and A375 RPPA heatmaps.
Supplemental Information from Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL Phosphatase
Authors: Bai Yunpeng , Yu Zhi-Hong , Liu Sijiu , Zhang Lujuan , Zhang Ruo-Yu , Zeng Li-Fan , Zhang Sheng , Zhang Zhong-Yin
Published: March 2023

Supplemental information
Supplementary Methods from Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma
Authors: Gopal Y.N. Vashisht , Rizos Helen , Chen Guo , Deng Wanleng , Frederick Dennie T. , Cooper Zachary A. , Scolyer Richard A. , Pupo Gulietta , Komurov Kakajan , Sehgal Vasudha , Zhang Jiexin , Patel Lalit , Pereira Cristiano G. , Broom Bradley M. , Mills Gordon B. , Ram Prahlad , Smith Paul D. , Wargo Jennifer A. , Long Georgina V. , Davies Michael A.
Published: March 2023

Supplementary Methods. This file contains detailed descriptions of some of the methods used for performing the experiments.
Supplementary Figures S1-S12 from Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma
Authors: Gopal Y.N. Vashisht , Rizos Helen , Chen Guo , Deng Wanleng , Frederick Dennie T. , Cooper Zachary A. , Scolyer Richard A. , Pupo Gulietta , Komurov Kakajan , Sehgal Vasudha , Zhang Jiexin , Patel Lalit , Pereira Cristiano G. , Broom Bradley M. , Mills Gordon B. , Ram Prahlad , Smith Paul D. , Wargo Jennifer A. , Long Georgina V. , Davies Michael A.
Published: March 2023

Supplementary Figures S1-S12. Figure S1. Ingenuity Pathway Analysis (IPA) and Netwalker analysis of the PLX4720-synthetic lethal genes. Figure S2. Effect of Selumetinib on the mitochondrial gene expression in high OxPhos MEL624 cell lines. Figure S3. Differential energy consumption and release in selumetinib-sensitive and resistant melanoma cell lines. Figure S4. Oxygen consumption in MEKi+mTORC1/2i combination-resistant and Ã¢??sensitive melanoma cell lines. Figure S5. Cellular effects of FDA approved single agent MEK and BRAF inhibitors Trametinib and Dabrafenib and their combinations with AZD8055. Figure S6. RPPA proteomic analysis of protein lysates from three combination-resistant (1) and three Ã¢??sensitive (2) BRAF mutant melanoma cell lines following MEK or mTORC1/2 inhibition. Figure S7. Correlation of MITF expression with selumetinib and AZD8055 combination synergy in 14 melanoma cell lines. Figure S8. Effect of selumetinib and AZD8055 on the cellular localization of MITF and consequence of MITF knockdown Figure S9. Comparative effects of AZD8055 and AZD2014. Figure S10. Drug concentration against percentage of cell growth inhibition. Figure S11. The proliferation of the A375, its resistant clones Ã¢??R1 and -R2, and WM35 and its resistant clones in presence of increasing concentrations of selumetinib, AZD8055 and their combination after 72 h treatment was determined as described in Figure S8. Figure S12. A) Ratio of PGC1ÃŽÂ± and MITF gene expression at the time of disease progression versus pre-treatment in the MGH cohort of patients treated with single-agent vemurafenib (MGH-25) or with dabrafenib + trametinib (all others). B) PGC1ÃŽÂ± expression in 917 cell lines of the Cancer Cell Line Encyclopedia (CCLE) representing 23 cancer types.
Supplementary Table 1 from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: March 2023

Supplementary Table 1. Differentially expressed genes were identified, as described in Material and Methods. Genes altered by BRG1 KD- Genes whose expression either increased or decreased in the H358 Brg1i.1 and H358 Brgi.2 cell lines; Upregulated and unregulated genes- We identified 316 genes that showed increased expression in both H358 Brg1i.1 and H358 Brg1i.2 cell lines. We also identified 300 genes that did not show altered expression in the Brg1i.2 cell line.
Supplementary Figure 4 from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: March 2023

Supplementary Figure 4. The figure shows kernal-smoothed data for nucleosome positioning about transcription start sites in the Brg1 KD human NSCLC cell line and in mouse SNF5 and Brg1 KO cells.