bluuebunny/crossref_metadata_2025 huggingface dataset:
An Energy-Efficient Optimization Method for High-Speed Rail Communication Systems Assisted by Intelligent Reflecting Surfaces (IRS)
Authors: Li Cuiran , Lu Yongjie , Xie Jianli , Zhang Zepeng
Published: August 2023

This paper proposes an intelligent reflecting surface (IRS)-assisted energy efficiency optimization algorithm to address the problem of energy efficiency (EE) degradation in high-speed rail communication systems caused by line-of-sight link blockages between base stations and trains. The joint optimization of base station beamforming and IRS phase shifts is formulated as a variable-coupled energy efficiency maximization problem, subject to the base station’s transmission power and the IRS unit’s modulus constraints. This is known to be an NP-hard problem, making it challenging to obtain the global optimal solution. To tackle the issue of optimization variable coupling, an alternating optimization is employed to decompose the original problem into two sub-problems: base station beamforming and IRS phase-shift optimization. The Dinkelbach method is utilized to convert the fractional objective function into a difference form; then, the successive convex approximation (SCA) algorithm is applied to transform non-convex constraints into convex ones, which are solved using CVX. The Riemann conjugate gradient (RCG) algorithm can effectively solve the difficult unit module constraint. Finally, an alternating iterative strategy is employed to converge to a suboptimal solution. Our simulation results demonstrate that the proposed algorithm significantly enhances system efficiency with low computational complexity. Specifically, when the number of IRS reflecting elements is 64, the system’s EE is improved by approximately 12.41%, 35.26%, and 37.96% compared to the semi-definite relaxation algorithm, the random phase shift approach, and no IRS scheme, respectively.
Tunability of Half Cycle Cutoff Harmonics with Inhomogeneously Enhanced Laser Pulse
Authors: Mandal Ankur
Published: August 2023

For homogeneous driving, half cycle harmonics and its corresponding half cycle cutoff (HCO) show prominent spectral features, allowing one to produce an isolated attosecond pulse with suitable filtering, or vice versa the retrieval of the driving pulse itself. The temporal profile and spatial dependence of the inhomogeneously enhanced field are two important factors that determine the high harmonic generation (HHG) near a plasmonic nanostructure. This leads us to the question of how the HHG spectra and, in particular, the corresponding half cycle harmonics modify with different types of inhomogeneously enhanced fields. To elucidate this, we have made a comparative study of the HHG in three different types of inhomogeneously enhanced laser pulses by employing the time-dependent Schrödinger equation in one dimension. Within our chosen parameter range, the HCO in cutoff and mid-plateau regimes shift towards higher order with the increase of strength of the inhomogeneity in isotropic case. In anisotropic inhomogeneity, the cutoff HCO shifts towards the higher order but the mid-plateau HCO shifts towards lower order with the increase of strength of inhomogeneity. With increasing carrier envelope phase (CEP), the enhanced HCO in the lower-order harmonic region shifts towards higher orders. This shift is nearly linear from near the above threshold to mid-plateau region and becomes saturated in the near cutoff region. The harmonic spectra is modulo-π periodic for the isotropic inhomogeneity and it is modulo-2π periodic for the anisotropic inhomogeneity. This extension of periodicity increases the tunability of the enhanced HCO harmonics with CEP in the anisotropic inhomogeneity than the CEP tuning of the HCO harmonics in the isotropic inhomogeneity or vice versa the retrieval of CEP.
Countably Generated Algebras of Analytic Functions on Banach Spaces
Authors: Novosad Zoriana , Vasylyshyn Svitlana , Zagorodnyuk Andriy
Published: August 2023

In the paper, we study various countably generated algebras of entire analytic functions on complex Banach spaces and their homomorphisms. Countably generated algebras often appear as algebras of symmetric analytic functions on Banach spaces with respect to a group of symmetries, and are interesting for their possible applications. Some conditions of the existence of topological isomorphisms between such algebras are obtained. We construct a class of countably generated algebras, where all normalized algebraic bases are equivalent. On the other hand, we find non-isomorphic classes of such algebras. In addition, we establish the conditions of the hypercyclicity of derivations in countably generated algebras of entire analytic functions of the bounded type. We use methods from the theory of analytic functions of several variables, the theory of commutative Fréchet algebras, and the theory of linear dynamical systems.
The Translation of Mobile-Exoneuromusculoskeleton-Assisted Wrist–Hand Poststroke Telerehabilitation from Laboratory to Clinical Service
Authors: Qing Wanyi , Nam Ching-Yi , Shum Harvey Man-Hok , Chan Marko Ka-Leung , Yu King-Pong , Ng Serena Sin-Wah , Yang Bibo , Hu Xiaoling
Published: August 2023

Rehabilitation robots are helpful in poststroke telerehabilitation; however, their feasibility and rehabilitation effectiveness in clinical settings have not been sufficiently investigated. A non-randomized controlled trial was conducted to investigate the feasibility of translating a telerehabilitation program assisted by a mobile wrist/hand exoneuromusculoskeleton (WH-ENMS) into routine clinical services and to compare the rehabilitative effects achieved in the hospital-service-based group (n = 12, clinic group) with the laboratory-research-based group (n = 12, lab group). Both groups showed significant improvements (p ≤ 0.05) in clinical assessments of behavioral motor functions and in muscular coordination and kinematic evaluations after the training and at the 3-month follow-up, with the lab group demonstrating better motor gains than the clinic group (p ≤ 0.05). The results indicated that the WH-ENMS-assisted tele-program was feasible and effective for upper limb rehabilitation when integrated into routine practice, and the quality of patient–operator interactions physically and remotely affected the rehabilitative outcomes.
Trehalose Production Using Three Extracellular Enzymes Produced via One-Step Fermentation of an Engineered Bacillus subtilis Strain
Authors: Sun Xi , Yang Jun , Fu Xiaoping , Zhao Xingya , Zhen Jie , Song Hui , Xu Jianyong , Zheng Hongchen , Bai Wenqin
Published: August 2023

At present, the double-enzyme catalyzed method using maltooligosyltrehalose synthase (MTSase) and maltooligosyltrehalose trehalohydrolase (MTHase) is the mainstream technology for industrial trehalose production. However, MTSase and MTHase are prepared mainly using the heterologous expression in the engineered Escherichia coli strains so far. In this study, we first proved that the addition of 3 U/g neutral pullulanase PulA could enhance the trehalose conversion rate by 2.46 times in the double-enzyme catalyzed system. Then, a CBM68 domain was used to successfully assist the secretory expression of MTSase and MTHase from Arthrobacter ramosus S34 in Bacillus subtilis SCK6. At the basis, an engineered strain B. subtilis PSH02 (amyE::pulA/pHT43-C68-ARS/pMC68-ARH), which co-expressed MTSase, MTHase, and PulA, was constructed. After the 24 h fermentation of B. subtilis PSH02, the optimum ratio of the extracellular multi-enzymes was obtained to make the highest trehalose conversion rate of 80% from 100 g/L maltodextrin. The high passage stability and multi-enzyme preservation stability made B. subtilis PSH02 an excellent industrial production strain. Moreover, trehalose production using these extracellular enzymes produced via the one-step fermentation of B. subtilis PSH02 would greatly simplify the procedure for multi-enzyme preparation and be expected to reduce production costs.
Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions
Authors: Jiménez-Jiménez Félix Javier , Alonso-Navarro Hortensia , García-Martín Elena , Santos-García Diego , Martínez-Valbuena Iván , Agúndez José A. G.
Published: August 2023

The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues (blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological fluids, except for cerebrospinal fluid (serum, plasma, saliva, feces, urine), as a marker of several diseases, has been the subject of numerous publications. This narrative review summarizes data from studies trying to determine the role of total, oligomeric, and phosphorylated aSyn determinations as a marker of various diseases, especially PD and other alpha-synucleinopathies. In summary, the results of studies addressing the determinations of aSyn in its different forms in peripheral tissues (especially in platelets, skin, and digestive tract, but also salivary glands and olfactory mucosa), in combination with other potential biomarkers, could be a useful tool to discriminate PD from controls and from other causes of parkinsonisms, including synucleinopathies.
The Impact of GLP-1 RAs and DPP-4is on Hospitalisation and Mortality in the COVID-19 Era: A Two-Year Observational Study
Authors: Greco Salvatore , Monda Vincenzo M. , Valpiani Giorgia , Napoli Nicola , Crespini Carlo , Pieraccini Fabio , Marra Anna , Passaro Angelina
Published: August 2023

Novel antidiabetic drugs have the ability to produce anti-inflammatory effects regardless of their glucose-lowering action. For this reason, these molecules (including GLP-1 RAs and DPP-4is) were hypothesized to be effective against COVID-19, which is characterized by cytokines hyperactivity and multiorgan inflammation. The aim of our work is to explore the potential protective role of GLP-1 RAs and DPP-4is in COVID-19 (with the disease intended to be a model of an acute stressor) and non-COVID-19 patients over a two-year observation period. Retrospective and one-versus-one analyses were conducted to assess the impact of antidiabetic drugs on the need for hospitalization (in both COVID-19- and non-COVID-19-related cases), in-hospital mortality, and two-year mortality. Logistic regression analyses were conducted to identify the variables associated with these outcomes. Additionally, log-rank tests were used to plot survival curves for each group of subjects, based on their antidiabetic treatment. The performed analyses revealed that despite similar hospitalization rates, subjects undergoing home therapy with GLP-1 RAs exhibited significantly lower mortality rates, even over a two-year period. These individuals demonstrated improved survival estimates both within hospital and non-hospital settings, even during a longer observation period.
Circulating and Exosomal microRNA-33 in Childhood Obesity
Authors: Cabiati Manuela , Guiducci Letizia , Randazzo Emioli , Casieri Valentina , Federico Giovanni , Del Ry Silvia
Published: August 2023

Background: MicroRNA-33 may control a wide range of different metabolic functions. Methods: This study aims to assess the miR-33a circulating profile in normal-weight (N = 20) and obese (O = 30) adolescents and to correlate its expression levels to their metabolic parameters. In a subset of subjects, we compared circulating miR-33a with exosomal miR-33a. Results: Metabolic parameters were altered in O, with initial hyperinsulinemia. Circulating miR-33a was significantly higher in O than in N (p = 0.0002). Significant correlations between miR-33a and auxological and metabolic indices (Insulin p = 0.01; Cholesterol p = 0.01; LDL p = 0.01; HbA1c p = 0.01) were found. Splitting our population (O + N) into two groups, according to the median value of mRNA expression miR-33a levels (0.701), irrespective of the presence or absence of obesity, we observed that those having a higher expression of miR-33a were more frequently obese (87.5% vs. 12.5%; p < 0.0001) and had significantly increased values of auxological and metabolic parameters. Exosomes extracted from plasma of N and O carried miR-33a, and its expression was lower in O (p = 0.026). No correlations with metabolic parameters were observed. Conclusion: While exosome miR-33a does not provide any advantage, circulating miR-33a can provide important indications in an initial phase of metabolic dysfunction, stratifying obese adolescents at higher cardiometabolic risk.
Sleep Traits Causally Affect the Brain Cortical Structure: A Mendelian Randomization Study
Authors: Chen Yanjing , Lyu Shiyi , Xiao Wang , Yi Sijie , Liu Ping , Liu Jun
Published: August 2023

Background: Brain imaging results in sleep deprived patients showed structural changes in the cerebral cortex; however, the reasons for this phenomenon need to be further explored. Methods: This MR study evaluated causal associations between morningness, ease of getting up, insomnia, long sleep, short sleep, and the cortex structure. Results: At the functional level, morningness increased the surface area (SA) of cuneus with global weighted (beta(b) (95% CI): 32.63 (10.35, 54.90), p = 0.004). Short sleep increased SA of the lateral occipital with global weighted (b (95% CI): 394.37(107.89, 680.85), p = 0.007. Short sleep reduced cortical thickness (TH) of paracentral with global weighted (OR (95% CI): −0.11 (−0.19, −0.03), p = 0.006). Short sleep reduced TH of parahippocampal with global weighted (b (95% CI): −0.25 (−0.42, −0.07), p = 0.006). No pleiotropy was detected. However, none of the Bonferroni-corrected p values of the causal relationship between cortical structure and the five types of sleep traits met the threshold. Conclusions: Our results potentially show evidence of a higher risk association between neuropsychiatric disorders and not only paracentral and parahippocampal brain areas atrophy, but also an increase in the middle temporal zone. Our findings shed light on the associations of cortical structure with the occurrence of five types of sleep traits.
Brugada Syndrome: More than a Monogenic Channelopathy
Authors: Liantonio Antonella , Bertini Matteo , Mele Antonietta , Balla Cristina , Dinoi Giorgia , Selvatici Rita , Mele Marco , De Luca Annamaria , Gualandi Francesca , Imbrici Paola
Published: August 2023

Brugada syndrome (BrS) is an inherited cardiac channelopathy first diagnosed in 1992 but still considered a challenging disease in terms of diagnosis, arrhythmia risk prediction, pathophysiology and management. Despite about 20% of individuals carrying pathogenic variants in the SCN5A gene, the identification of a polygenic origin for BrS and the potential role of common genetic variants provide the basis for applying polygenic risk scores for individual risk prediction. The pathophysiological mechanisms are still unclear, and the initial thinking of this syndrome as a primary electrical disease is evolving towards a partly structural disease. This review focuses on the main scientific advancements in the identification of biomarkers for diagnosis, risk stratification, pathophysiology and therapy of BrS. A comprehensive model that integrates clinical and genetic factors, comorbidities, age and gender, and perhaps environmental influences may provide the opportunity to enhance patients’ quality of life and improve the therapeutic approach.
Thrombosis and Hyperinflammation in COVID-19 Acute Phase Are Related to Anti-Phosphatidylserine and Anti-Phosphatidylinositol Antibody Positivity
Authors: Alijotas-Reig Jaume , Anunciación-Llunell Ariadna , Morales-Pérez Stephanie , Trapé Jaume , Esteve-Valverde Enrique , Miro-Mur Francesc
Published: August 2023

Antiphospholipid antibodies (APLA) are strongly associated with thrombosis seen in patients with antiphospholipid syndrome. In COVID-19, thrombosis has been observed as one of the main comorbidities. In patients hospitalised for COVID-19, we want to check whether APLA positivity is associated with COVID-19-related thrombosis, inflammation, severity of disease, or long COVID-19. We enrolled 92 hospitalised patients with COVID-19 between March and April 2020 who were tested for 18 different APLAs (IgG and IgM) with a single line-immunoassay test. A total of 30 healthy blood donors were used to set the cut-off for each APLA positivity. Of the 92 COVID-19 inpatients, 30 (32.61%; 95% CI [23.41–43.29]) tested positive for APLA, of whom 10 (33.3%; 95% CI [17.94–52.86]) had more than one APLA positivity. Anti-phosphatidylserine IgM positivity was described in 5.4% of inpatients (n = 5) and was associated with the occurrence of COVID-19-related thrombosis (p = 0.046). Anti-cardiolipin IgM positivity was the most prevalent among the inpatients (n = 12, 13.0%) and was associated with a recorded thrombosis in their clinical history (p = 0.044); however, its positivity was not associated with the occurrence of thrombosis during their hospitalisation for COVID-19. Anti-phosphatidylinositol IgM positivity, with a prevalence of 5.4% (n = 5), was associated with higher levels of interleukin (IL)-6 (p = 0.007) and ferritin (p = 0.034). Neither of these APLA positivities was a risk factor for COVID-19 severity or a predictive marker for long COVID-19. In conclusion, almost a third of COVID-19 inpatients tested positive for at least one APLA. Anti-phosphatidylserine positivity in IgM class was associated with thrombosis, and anti-phosphatidylinositol positivity in IgM class was associated with inflammation, as noticed by elevated levels of IL-6. Thus, testing for non-criteria APLA to assess the risk of clinical complications in hospitalised COVID-19 patients might be beneficial. However, they were not related to disease severity or long COVID-19.
PSO-Incorporated Hybrid Artificial Hummingbird Algorithm with Elite Opposition-Based Learning and Cauchy Mutation: A Case Study of Shape Optimization for CSGC–Ball Curves
Authors: Chen Kang , Chen Liuxin , Hu Gang
Published: August 2023

With the rapid development of the geometric modeling industry and computer technology, the design and shape optimization of complex curve shapes have now become a very important research topic in CAGD. In this paper, the Hybrid Artificial Hummingbird Algorithm (HAHA) is used to optimize complex composite shape-adjustable generalized cubic Ball (CSGC–Ball, for short) curves. Firstly, the Artificial Hummingbird algorithm (AHA), as a newly proposed meta-heuristic algorithm, has the advantages of simple structure and easy implementation and can quickly find the global optimal solution. However, there are still limitations, such as low convergence accuracy and the tendency to fall into local optimization. Therefore, this paper proposes the HAHA based on the original AHA, combined with the elite opposition-based learning strategy, PSO, and Cauchy mutation, to increase the population diversity of the original algorithm, avoid falling into local optimization, and thus improve the accuracy and rate of convergence of the original AHA. Twenty-five benchmark test functions and the CEC 2022 test suite are used to evaluate the overall performance of HAHA, and the experimental results are statistically analyzed using Friedman and Wilkerson rank sum tests. The experimental results show that, compared with other advanced algorithms, HAHA has good competitiveness and practicality. Secondly, in order to better realize the modeling of complex curves in engineering, the CSGC–Ball curves with global and local shape parameters are constructed based on SGC–Ball basis functions. By changing the shape parameters, the whole or local shape of the curves can be adjusted more flexibly. Finally, in order to make the constructed curve have a more ideal shape, the CSGC–Ball curve-shape optimization model is established based on the minimum curve energy value, and the proposed HAHA is used to solve the established shape optimization model. Two representative numerical examples comprehensively verify the effectiveness and superiority of HAHA in solving CSGC–Ball curve-shape optimization problems.
Potential for Net-Zero Energy Communities in Kuwait: An Empirical Techno-Economic Modeling and Optimization Approach
Authors: Alaifan Bader , Azar Elie
Published: August 2023

A net-zero energy community (NZEC) is a promising paradigm that can directly contribute to a sustainable building sector and infrastructure. This research presents a unique empirical techno-economic optimization and evaluation approach for NZEC potential and enablers through its application to the understudied context of Kuwait. The proposed approach is unique, as it integrates data-driven and physics-based modelling capabilities, captures the impact of urban form on NZEC techno-economic performance, and quantifies through sensitivity analyses the impact of potential enablers in overcoming financial barriers to adoption. Results indicate that NZECs are far from being competitive in Kuwait compared to the business-as-usual scenario of electricity grid purchase at highly subsidized tariffs. Increasing electricity rates to a minimum of 0.03 $/kWh is recommended, coupled with investing in energy efficiency and enabling grid sell-back capabilities. Finally, results indicate that the energy demand profiles of office and multi-family buildings are more advantageous for efficient NZEC design and performance than villas, the most predominant building type in Kuwait. Limiting the share of NZEC energy demand from villas to 25% helps avoid excessive energy generation and storage capacities and costs.
Stress Evaluation in Axially Loaded Members of Masonry Buildings and Space Structures: From Traditional Methods to Combinations with Artificial Intelligence Approaches
Authors: Bonopera Marco
Published: August 2023

Stress state evaluation in axially loaded structural members is significant for sustaining and preserving the service life of buildings. While successful monitoring furnishes staunch information on the health, integrity, safety and serviceability of structures, maintaining the structural performance of a building with time significantly depends on assessing the occurrence. Variations in the stress in axially loaded members may occur in masonry buildings or space structures caused by different conditions and human-induced factors. In the last decades, numerous nondestructive methods have been generated to furnish practical means for identifying axial load in the tie-rods of masonry buildings and in the structural members of space structures. Significant effort has been put into dynamic-based approaches, which make use of the vibrational response of the monitored member to investigate its condition and evaluate the axial load. In particular, wide laboratory and field tests have been executed worldwide, resulting in several findings. Meanwhile, with flourishing sensing technology and computing power, Artificial Intelligence (AI) applications, such as hybrid methods, optimization techniques and deep learning algorithms, have become more practicable and widely used in vibration-based axial stress prediction, with efficiency and, frequently, with strict precision. While there have been various manuscripts published on dynamic-based axial stress evaluation, there are no works in which the passage from traditional methods to combinations with AI approaches have been illustrated. This article aims to address this gap by introducing the highlights of the traditional methods, and furnish a review of the applications of AI techniques used for nondestructive-based axial stress prediction in tie-rods and structural members. Conclusions, including further studies and field developments, have also been mentioned at the end of the article.
Opposing Roles of Blood-Borne Monocytes and Tissue-Resident Macrophages in Limbal Stem Cell Damage after Ocular Injury
Authors: Zhou Chengxin , Lei Fengyang , Mittermaier Mirja , Ksander Bruce , Dana Reza , Dohlman Claes H. , Vavvas Demetrios G. , Chodosh James , Paschalis Eleftherios I.
Published: August 2023

Limbal stem cell (LSC) deficiency is a frequent and severe complication after chemical injury to the eye. Previous studies have assumed this is mediated directly by the caustic agent. Here we show that LSC damage occurs through immune cell mediators, even without direct injury to LSCs. In particular, pH elevation in the anterior chamber (AC) causes acute uveal stress, the release of inflammatory cytokines at the basal limbal tissue, and subsequent LSC damage and death. Peripheral C-C chemokine receptor type 2 positive/CX3C motif chemokine receptor 1 negative (CCR2+ CX3CR1−) monocytes are the key mediators of LSC damage through the upregulation of tumor necrosis factor-alpha (TNF-α) at the limbus. In contrast to peripherally derived monocytes, CX3CR1+ CCR2− tissue-resident macrophages have a protective role, and their depletion prior to injury exacerbates LSC loss and increases LSC vulnerability to TNF-α-mediated apoptosis independently of CCR2+ cell infiltration into the tissue. Consistently, repopulation of the tissue by new resident macrophages not only restores the protective M2-like phenotype of macrophages but also suppresses LSC loss after exposure to inflammatory signals. These findings may have clinical implications in patients with LSC loss after chemical burns or due to other inflammatory conditions.
Butterflies and Ribbons: Supporting Families Experiencing Perinatal Loss in Multiple Gestation
Authors: Boutillier Béatrice , Embleton Nicholas D. , Bélanger Sophie , Bigras-Mercier Alexie , Larone Juneau Audrey , Barrington Keith J. , Janvier Annie
Published: August 2023

Introduction: In neonatology, multiple pregnancies are common. Unfortunately, it is not rare for one baby to die. Communication with parents in these circumstances has been demonstrated to be sub-optimal. Methods: Two educational programs were evaluated with pre- and post-course surveys, questionnaires administered to participants, and audits. Results: In the online Butterfly project (UK; n = 734 participants), all participants reported that the training exceeded or met their expectations, 97% reported they learned new skills, and 48% had already applied them. Participants expressed gratitude in their open-ended answers: “I feel a lot more confident in supporting parents in this situation”. In the Ribbon project (workshop for neonatal clinicians, Quebec; n = 242), 97% were satisfied with the training and reported feeling more comfortable caring for bereaved parents. Knowledge improved pre–post training. Audits revealed that 100% of cases were identified on the incubator and the baby’s/babies’ admission card, all changed rooms after the death of their co-twin/triplet, and all had the name of their co-twin/triplet on the discharge summary. All clinicians (55) knew what the ribbon symbol meant when asked during surprise audits at the bedside. Conclusion: Different educational strategies to optimize communication with families after the perinatal loss of a co-twin are appreciated and have a positive impact.
Analysis of Genes Related to Invadopodia Formation and CTTN in Oral Squamous Cell Carcinoma—A Systematic Gene Expression Analysis
Authors: Desel Immanuel , Jung Susanne , Purcz Nikolai , Açil Yahya , Sproll Christoph , Kleinheinz Johannes , Sielker Sonja
Published: August 2023

Successful treatment for any type of carcinoma largely depends on understanding the patterns of invasion and migration. For oral squamous cell carcinoma (OSCC), these processes are not entirely understood as of now. Invadopodia and podosomes, called invadosomes, play an important role in cancer cell invasion and migration. Previous research has established that cortactin (CTTN) is a major inducer of invadosome formation. However, less is known about the expression patterns of CTTN and other genes related to it or invadopodia formation in OSCC during tumor progression in particular. In this study, gene expression patterns of CTTN and various genes (n = 36) associated with invadopodia formation were analyzed to reveal relevant expression patterns and give a comprehensive overview of them. The genes were analyzed from a whole genome dataset of 83 OSCC samples relating to tumor size, grading, lymph node status, and UICC (Union for Internatioanl Cancer Control). The data revealed significant overexpression of 18 genes, most notably CTTN, SRC (SRC proto-onocogene, non-receptor tyrosine kinase), EGFR (epidermal growth factor receptor), SYK (spleen associated tyrosine kinase), WASL (WASP like actin nucleation promotion factor), and ARPC2 (arrestin beta 1) due to their significant correlation with further tumor parameters. This study is one of the first to summarize the expression patterns of CTTN and related genes in a complex group of OSCC samples.
Influence of Dimple Diameter and Depth on Heat Transfer of Impingement-Cooled Turbine Leading Edge with Cross-Flow and Dimple
Authors: Qu Bin , Chen Zilong , He Dengke , Zeng Fei , Song Youfu , Ouyang Yuqing , Luo Lei
Published: August 2023

Today, impingement cooling structures with dimples can effectively ease the burden of turbine blades. This paper investigates the effect of dimple diameter and depth on the heat transfer of the target surface on a laminar-cooled turbine blade with a cross-flow and dimple numerically to find the mechanism behind it so that the dimple can be better used in turbine cooling. The commercial software ANSYS 19.2 and a baseline (BSL) turbulence model is used during the numerical computation. In this paper, the cross-flow Reynolds number varies from 15,000 to 60,000, while the jet Reynolds number remains at 30,000. When the cross-flow Reynolds number changes, due to the location change in vortexes generated inside or around the dimple, the two dimple parameters affect heat transfer differently. When the cross-flow Reynolds number is lower than the jet Reynolds number, dimples with smaller diameters and depths lead to better heat transfer performance. When the cross-flow Reynolds number exceeds the jet Reynolds number, dimples with bigger diameters and depths result in better heat exchange performance. The results also indicate that, while the dimple diameters remain constant, the rise of the cross-flow Reynolds number enhances the heat transfer of the dimple structure.
The Impact of the Test Dissociation on the Binocular Balance of Children
Authors: Ibrahimi Danjela , Aviles Marcos , Rodríguez-Reséndiz Juvenal
Published: August 2023

Purpose: this research compared the dissociated phoria at near and distance fixation in free space using the Howell test, alternate Cover test, and Thorington test. Methods: 220 healthy Mexican children (mean age 8.3±2.5 years) participated in this study. Phorias were quantified at both distances using each test, from the least to the most disruptive. The stereopsis degree and near point of convergence (break/recovery) were analyzed to understand their role in the visual system’s sensorimotor balance. Results: statistically significant differences were found among techniques, with a higher congruence for the EF. However, only the Howell and Thorington tests can be interchanged. The break value and near exophoria relate to each other and affect the stereopsis degree, whereas age is associated with the stereopsis degree and break value. Conclusions: the three techniques cannot be interchanged except for the Howell and Thorington test for the EF at far. The differences in the mode of dissociation could relate to the results.
Influence of Substrate on the Tribological Behavior of Inconel 625 GMAW Overlays
Authors: Ferreira Filho Demostenes , Souza Daniel , Gonçalves Júnior José Lúcio , Reis Ruham Pablo , Da Silva Junior Washington Martins , Tavares Amanda Figueira
Published: August 2023

This study investigates the microstructure and tribological behavior of Inconel 625 overlays applied via GMAW (Gas Metal Arc Welding) with and without a 316LSi stainless-steel intermediate layer on top of A36 steel. The microstructural characterization was conducted via FESEM with EDS. The tribological behavior was evaluated using a tribometer in a reciprocating configuration. The results showed that the wear rate of the Inconel 625 weld overlay with the 316LSi intermediate layer was higher than without it. However, no variations were observed in terms of hardness and the friction coefficient of the Inconel 625 weld overlays. The difference in the behavior of the two coatings was justified due to the microstructure morphology found in each case and chemical composition. When applied without the intermediate layer, Inconel 625 coating’s structure was dendritic, whereas it was cellular otherwise. An increase in the amount of Nb was observed in the layer deposited over 316LSi. This rise likely led to an increase in the number of precipitates and/or Laves phase formation. Thus, the results indicated that the difference in thermal conductivity and dilution between the stainless and carbon steels modifies the morphology of the microstructure of the Inconel 625 weld overlay, decreasing wear resistance when deposited on top of the stainless steel.
Long-Term Performance Analysis of Epoxy Resin Ultra-Thin Wearing Course Overlay on Cement Concrete Pavement
Authors: Zheng Xiaoguang , Chen Yajie , Xu Wanwan , Zhang Zhen , Sun Guoqiang , Wang Tao
Published: August 2023

The overall rigidity of the cement concrete pavement is high, but there are defects such as easy cracking and insufficient anti-slip performance. The epoxy resin ultra-thin wearing course overlay can effectively solve these issues. However, there is still a lack of knowledge about the long-term performance of epoxy resin ultra-thin wearing course overlay on cement concrete pavement. Therefore, this article analyzed the interlayer adhesion and durability of epoxy resin ultra-thin wearing course overlay through the Hamburg rutting test and a series of shear tests under damp heat, thermal oxygen aging, and ultraviolet (UV) aging conditions. Shear test results indicated that the shear performance of epoxy resin overlay grew with the increase in epoxy resin content and was severely affected by high temperature, and the optimal content was set as 3.4 kg/m2. The Hamburg rutting test results showed that the epoxy resin overlay exhibited satisfactory high-temperature performance and water resistance. For the damp heat effect, it was revealed that damp heat led to more significant shear strength loss compared with the overlay specimens without damp heat. The water immersion caused the shear strength decline due to the water damage to the overlay interface. As for the thermal oxygen aging effect, it was reflected that the short-term thermal oxygen aging had a minor impact on the shear performance of the epoxy resin overlay. However, with the increase in thermal oxygen aging duration, the shear strength of the epoxy resin overlay significantly decreased due to the aging of epoxy resin binders. Regarding the UV aging impact, it was also found that the shear performance of the epoxy resin overlay rapidly decreased as the UV aging duration grew whether at 20 °C or 60 °C. Moreover, UV aging led to a more significant impact on the shear performance of the epoxy resin overlay than thermal oxygen aging.
Recent Advances in Metal–Organic Frameworks for the Surface Modification of the Zinc Metal Anode: A Review
Authors: Xing Yibo , Feng Kaijia , Kong Chunyang , Wang Guangbin , Pei Yifei , Huang Qixiang , Liu Yong
Published: August 2023

Aqueous zinc ion batteries (AZIBs) are considered as one of the most promising energy storage technologies due to their advantages of being low in cost, high in safety, and their environmental friendliness. However, dendrite growth and parasitic side reactions on the zinc metal anode during cycling lead to a low coulombic efficiency and an unsatisfactory lifespan, which seriously hinders the further development of AZIBs. In this regard, metal–organic frameworks (MOFs) are deemed as suitable surface modification materials for the Zn anode to deal with the abovementioned problems because of their characteristics of a large specific surface area, high porosity, and excellent tunability. Considering the rapidly growing research enthusiasm for this topic in recent years, herein, we summarize the recent advances in the design, fabrication, and application of MOFs and their derivatives in the surface modification of the zinc metal anode. The relationships between nano/microstructures, synthetic methods of MOF-based materials, and the enhanced electrochemical performance of the zinc metal anode via MOF surface modification are systematically summarized and discussed. Finally, the existing problems and future development of this area are proposed.
Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Porphyromonas gingivalis
Authors: Hwang Jisub , Do Hackwon , Shim Youn-Soo , Lee Jun Hyuck
Published: August 2023

Aspartate semialdehyde dehydrogenase (ASADH) catalyzes the biosynthesis of several essential amino acids, including lysine, methionine, and threonine, and bacterial cell components. Thus, ASADH is a crucial target for developing new antimicrobial agents that can potentially disrupt the biosynthesis of essential amino acids, thereby inhibiting the growth of pathogens. Herein, the crystal structures of ASADH obtained from Porphyromonas gingivalis (PgASADH, UniProtKB code A0A1R4DY25) were determined in apo- and adenosine-2′-5′-diphosphate (2′,5′-ADP)-bound complex forms at a resolution of 1.73 Å. The apo- and 2′,5′-ADP-complexed crystals of PgASADH belonged to the space groups of I212121 and C2221, respectively. Analytical size-exclusion chromatography showed a stable PgASADH dimer in a solution. Clustering analysis and structural comparison studies performed on PgASADH and previously known ASADHs revealed that ASADHs, including PgASADH, can be classified into three types depending on sequential and structural differences at the α-helical subdomain region. These findings provide valuable insights into developing structure-based species-specific new antibacterial drugs against the oral pathogen P. gingivalis.
Age-Specific Trends of Invasive Cervical Cancer Incidence in British Columbia, Canada, 1971–2017
Authors: Raveinthiranathan Nivedha , Simkin Jonathan , Donken Robine , Ogilvie Gina , Smith Laurie , Van Niekerk Dirk , Lee Marette , Woods Ryan R.
Published: August 2023

This study examined invasive cervical cancer (ICC) incidence trends in British Columbia (BC) by age and stage-at-diagnosis relative to World Health Organization ICC elimination targets (4 per 100,000 persons). Incident ICC cases (1971–2017) were obtained from the BC Cancer Registry. Annual age-standardized incidence rates (ASIRs) per 100,000 persons were generated using the direct method. ASIRs were examined among all ages 15+ years and eight age groups using Joinpoint Regression with the Canadian 2011 standard population. Standardized rate ratios (SRRs) compared stage II–IV (late) versus stage I (early) ASIRs by age (2010–2017). ICC ASIRs did not reach the elimination target. ASIRs declined from 18.88 to 7.08 per 100,000 persons (1971–2017). Stronger declines were observed among ages 45+ years, with the largest decline among ages 70–79 years (AAPC = −3.2%, 95% CI = −3.9% to −2.6%). Among ages 25–69 years, varying levels of attenuation in declining trends and stabilization were observed since the 1980s. SRRs indicated higher rates of late-stage ICC among ages 55+ years (SRR−55–69 years = 1.34, 95% CI = 1.08–1.71). Overall, ICC incidence declined in BC since 1971 but did not reach the elimination target. The pace of decline varied across age groups and increased with age. Continued efforts are needed to progress cervical cancer elimination among all age groups.
Study on the Mechanism of the Pink Tooth Phenomenon Using Bovine Teeth: A Pilot Study
Authors: Sumi Nozomi , Minegishi Saki , Ohta Jun , Utsuno Hajime , Sakurada Koichi
Published: August 2023

The pink teeth phenomenon has occasionally been observed in forensic autopsies. This study aimed to establish an experimental pink tooth model and an objective color tone evaluation method in order to clarify changes in the color tone of teeth and the relationship with hemoglobin monoxide and its decomposition products and with red pigment-producing bacteria, under various external environmental factors. It was confirmed that the color tone evaluation with ΔE and the L*C*h color space was useful. The results of various examinations using this model showed that color development was suppressed under aerobic conditions, faded early under light, became bright red under a low temperature and showed a tendency to be reddish at 3 days under high humidity and in the presence of soft tissue. The biochemical analysis revealed a significant increase in carboxyhemoglobin at 7 days and a tendency toward increasing the total heme pigment and bilirubin levels over time. The bacteriological analysis revealed that red pigment-producing bacteria increased over time but that the color faded after 7 days. These results suggest that putrefaction greatly affects the pink teeth phenomenon, whereas red pigment-producing bacteria have little effect on the occurrence of pink teeth. However, further studies are needed to clarify bacteriological involvement.
Dental Therapy of Patients Prior to Endoprostheses: A Retrospective, Telephone-Based Cohort Study
Authors: Schmalz Gerhard , Wirtz Julian , Haak Rainer , Fenske Fabian , Roth Andreas , Ziebolz Dirk
Published: August 2023

The aim of this study was to assess, whether patients prior to endoprosthesis (EP) visit their dentist for need-oriented therapy and whether this would be associated with the occurrence of complications. Based on a cohort of patients, which was orally investigated prior to EP surgery between 04/2020 and 12/2021, a telephone interview was performed at least six months after EP implantation. Patients were classified into either low-risk (LR), moderate-risk (MR), or high-risk (HR) groups. Participants were interviewed based on a structured questionnaire regarding dental visits, dental therapy, and potential complications during the observational period. Out of the 311 patients from the baseline cohort, 96 patients after EP implantation could be included (participation rate of 31%). Nineteen patients were in LR (20%), 41 in MR (43%), and 36 in the HR group (37%). Overall, 79% (n = 76) of the patients followed the recommendation to visit their dentist; 94% of patients within the HR group visited the dentist (p = 0.02). Dental treatment procedures included tooth cleaning (57%), periodontal treatment (31%), restorative therapy/filling (28%), and tooth extraction (28%). In 64% of the HR patients (n = 23), the potential oral foci with a risk of EP infection were eliminated by their general dentist. Fourteen different complications occurred within the observation period, without any group effect (p > 0.05). In conclusion, most patients prior to EP visit their general dentist following referral, especially if they have a potential oral focus. The effect of dental clearance on infectious complications of EP remains unclear, whereby further clinical studies are needed.
Multi-User PIR with Cyclic Wraparound Multi-Access Caches
Authors: Vaidya Kanishak , Rajan Balaji Sundar
Published: August 2023

We consider the problem of multi-access cache-aided multi-user Private Information Retrieval (MACAMuPIR) with cyclic wraparound cache access. In MACAMuPIR, several files are replicated across multiple servers. There are multiple users and multiple cache nodes. When the network is not congested, servers fill these cache nodes with the content of the files. During peak network traffic, each user accesses several cache nodes. Every user wants to retrieve one file from the servers but does not want the servers to know their demands. This paper proposes a private retrieval scheme for MACAMuPIR and characterizes the transmission cost for multi-access systems with cyclic wraparound cache access. We formalize privacy and correctness constraints and analyze transmission costs. The scheme outperforms the previously known dedicated cache setup, offering efficient and private retrieval. Results demonstrate the effectiveness of the multi-access approach. Our research contributes an efficient, privacy-preserving solution for multi-user PIR, advancing secure data retrieval from distributed servers.
Nonequilibrium Thermodynamics of the Majority Vote Model
Authors: Hawthorne Felipe , Harunari Pedro E. , de Oliveira Mário J. , Fiore Carlos E.
Published: August 2023

The majority vote model is one of the simplest opinion systems yielding distinct phase transitions and has garnered significant interest in recent years. This model, as well as many other stochastic lattice models, are formulated in terms of stochastic rules with no connection to thermodynamics, precluding the achievement of quantities such as power and heat, as well as their behaviors at phase transition regimes. Here, we circumvent this limitation by introducing the idea of a distinct and well-defined thermal reservoir associated to each local configuration. Thermodynamic properties are derived for a generic majority vote model, irrespective of its neighborhood and lattice topology. The behavior of energy/heat fluxes at phase transitions, whether continuous or discontinuous, in regular and complex topologies, is investigated in detail. Unraveling the contribution of each local configuration explains the nature of the phase diagram and reveals how dissipation arises from the dynamics.
First Detection and Tunneling Time of a Quantum Walk
Authors: Ni Zhenbo , Zheng Yujun
Published: August 2023

We consider the first detection problem for a one-dimensional quantum walk with repeated local measurements. Employing the stroboscopic projective measurement protocol and the renewal equation, we study the effect of tunneling on the detection time. Specifically, we study the continuous-time quantum walk on an infinite tight-binding lattice for two typical situations with physical reality. The first is the case of a quantum walk in the absence of tunneling with a Gaussian initial state. The second is the case where a barrier is added to the system. It is shown that the transition of the decay behavior of the first detection probability can be observed by modifying the initial condition, and in the presence of a tunneling barrier, the particle can be detected earlier than the impurity-free lattice. This suggests that the evolution of the walker is expedited when it tunnels through the barrier under repeated measurement. The first detection tunneling time is introduced to investigate the tunneling time of the quantum walk. In addition, we analyze the critical transitive point by deriving an asymptotic formula.
Buy Now Pay Later—A Fad or a Reality? A Perspective on Electronic Commerce
Authors: Lupșa-Tătaru Dana Adriana , Nichifor Eliza , Dovleac Lavinia , Chițu Ioana Bianca , Todor Raluca Dania , Brătucu Gabriel
Published: August 2023

The Millennials and Generation Z use online shopping for a holistic experience and buy more expensive or better-quality products with buy now pay later payment methods for their highly demanding needs. The authors aimed to deepen understanding of this phenomenon by finding related knowledge fields and discovering the type of economy that will represent an increasing market share for the method of domestic e-commerce payments. The methodology used combined computer-assisted review, descriptive statistics, and linear regression to explain the market share of 23 economies worldwide. Student credit card use, myopic consumer law, buying tendencies. and dark financial triangles were identified as related topics. Logistics performance, ease of doing business, and postal development were found to be significant factors. Finally, economies with medium ranks are inclined to adopt this kind of payment easily. Hence, major implications, both managerial and academic, must be addressed. High responsibility should be borne by industry associations, which should run information campaigns by collaborating with public institutions. From the point of view of theoretical implications, studying the buy now and pay later concept and its outcomes might deepen understanding of consumer behaviour, decision-making processes, risk perception mitigation, debt behaviours, and credit adoption.