bluuebunny/crossref_metadata_2025 huggingface dataset:
THE MORPHOFUNCTIONAL STATE OF THE ORGANS OF IMMUNE SYSTEM AND LYMPHOCYTE SUBSETS IN THE PERIPHERAL BLOOD OF FEMALE WISTAR RATS IN DIFFERENT PHASES OF THE ESTROUS CYCLE
Authors: Simonova E Yu , Kosyreva A M
Published: October 2016

Differences in the morphofunctional state of the immune system of female Wistar rats in different phases of the estrous cycle are revealed. In the phase of diestrus the indices of cortex volume fraction of thymus and volume fraction of white pulp and marginal zone of lymphoid follicles of spleen are higher; the indices of subcapsular layer width of thymus and index of stimulation of granulocytes in the peripheral blood are lower as compared with the phase of proestrus. Differences in the absolute count and the percentage of T and B lymphocytes, T helpers, cytotoxic, activated and regulatory T cells in the peripheral blood of female rats in the phases of proestrus and diestrus aren’t revealed.
PREVENTION OF POSTOPERATIVE ANEMIA IN PATIENTS WITH TUBERCULOSIS
Authors: Nikolaev A N , Demikhov V G , Dobin V L , Inyakova N V , Oskin D N , Morshchakova E F
Published: October 2016

The study included 28 patients with pulmonary tuberculosis and a possible postoperative hemoglobin level of less than 120 g/l. For the prevention of postoperative anemia it is used recombinant human erythropoietin alpha and iron (III) hydroxide sucrose complex. Hemoglobin levels were monitored for 4 weeks after surgery and it is estimated the need for blood transfusions. Use of recombinant human erythropoietin and iron sucrose in patients with pulmonary tuberculosis increases basic hematological parameters as compared with the control group, and reduces the risk of postoperative anemia.
FUNCTIONAL ACTIVITY OF P-GLYCOPROTEIN DURING EXPERIMENTAL MANIPULATIONS
Authors: Yakusheva E N , Shulkin A V , Chernykh I V , Titov D S
Published: October 2016

In a study on rabbits the effect of experimental manipulations (false surgery and distilled water administration) on functional P-glycoprotein activity was studied. P-glycoprotein activity was assessed by pharmacokinetic analysis of its marker substrate - fexofenadine. Found that manipulations applied do not lead to modulation of Pgp activity at all stages of the research period.
AIR POLLUTION OF THE CENTRAL CITY OF THE REGION BY CARCINOGENS
Authors: Dementiev A A
Published: October 2016

In the article based on the result of simulation modeling there are maximum one time concentrations of carcinogens, released to the air with emission of stationary sources. We did comparative analysis of the air pollution levels in the service districts of children's city polyclinics according to annual mean concentrations of individual carcinogens in the air and percentage of the receptor points where their calculated concentrations did not comply with the hygienic norms.
THE ACADEMICIAN N.P. KRAVKOV IN THE YEARS OF WORLD WAR I (A FEW TOUCHES TO A PORTRAIT OF THE SCIENTIST)
Authors: Uzbekova D G
Published: October 2016

The material is given in article about activity of the founder of the domestic school of pharmacologists of the academician N. P. Kravkov in the years of World War I devoted to the first centenary of its beginning. On the instructions of the military department N.P. Kravkov actively participated in the work on studying of war poisoning gases in connection with the beginning of their application by armies of the opponent. Within the same years N.P. Kravkov performed scientific works on toxicology of the Caucasian gasolines.
THE EFFECT OF THE COMPLEX TREATMENT INVOLVING AFOBAZOL ON THE CONDITION OF THE IMMUNE SYSTEM OF PSORIASIS PATIENTS
Authors: Razumnaya F G , Zarudy F S , Kapuler O M
Published: October 2016

The prescription of pscychopharmacological medications belonging to the group of benzimidazole derivatives has a positive effect during a complex treatment for psoriasis patients. It decreases the secretion of TNFa, IL-2, INFy cytokines changing the structure and the subpopulations of T-lymphocytes which leads to a more intensive decrease in immunoregulatory coefficient ОД4+/СД8+.
THE COMBINED OPERATIONS AT PATIENTS WITH MORBID OBESITY
Authors: Yudin V A , Sazhin V P , Melnikov A A , Osipov V V , Usachev I A , Ivanov V V , Melnikova I A
Published: October 2016

The material of this work presents the problem of surgical treatment of patients with severe obesity. The assessment of the methods applied by authors in combined bariatric operations is given on the oun material.
WAYS OF EXPERIMENTAL MODELING OF VENOUS ENDOTHELIAL DYSFUNCTION: THE PRESENT STATE OF PROBLEM
Authors: Kalinin R E , Suchkov I A , Pshennikov A S , Novikov A N
Published: October 2016

Based on the literature data concerning modeling of venous diseases in experiments on animals the authors discuss various models of venous endothelial dysfunction. The models of venous thrombosis and L-NAME-induced endothelial dysfunction are considered to be the simplest and most readily reproducible.
ACUTE INTESTINAL INFECTIONS IN CHILDREN. A NEW LOOK AT AN OLD PROBLEM
Authors: Lobzin Yu V , Anokhin V A , Khaliullina S V
Published: October 2016

The article presents an overview of modem ideas about the etiological structure, principles of diagnosis and therapy of acute intestinal infections in children. The authors comment on the features of the diagnosis and treatment of these patients, existing today in the domestic and foreign practice. As part of evidence-based medicine shows the efficacy of various drugs for the treatment of children with infectious diarrhea. The authors used the results of their research to substantiate their position in discussions on several issues of improving diagnostic and therapeutic approaches in working with patients with acute intestinal infections.
PSYCHOLOGICAL DISORDERS IN PATIENTS WITH VIRAL HEPATITIS
Authors: Raduto O I
Published: October 2016

It reviewed the literature data on changes in the psycho-emotional status of patients with chronic viral hepatitis. Shown that chronic hepatitis have a significant effect on the mental state of patients, with the severity of psychological disorders depends on the clinical laboratory and morphological characteristics of the disease. The information about the observable signs of socio-psychological maladjustment, raising the level of anxiety, symptoms of depression in patients with chronic hepatitis. Shows a higher risk of contracting hepatitis B virus to patients in a psychiatric hospital. It confirmed the importance of timely diagnosis and correction of mental disorders in patients with chronic hepatitis, as well as the need to examine individual characteristics and mental abnormalities that may act as factors causing risk behavior in these patients.
ULTRASTRUCTURAL CHARACTERISTICS OF THE REMODELING VENTRICULAR ELECTRIC PATHWAYS BETWEEN CARDIOMYOCYTES AFTER THE INFLUENCE OF CHRONIC PRENATAL HYPOXIA IN EXPERIENCE
Authors: Petruk N S , Tverdokhleb I V
Published: October 2016

The aim of this work was to determine the influence of chronic prenatal hypoxia on remodeling of gap junctions in cardiomyocytes in rat ventricular myocardium at different stages of postnatal ontogeny. Chronic prenatal hypoxia to decline total and mean individual profile length of the gap junction per 100 μm intercalated disk in comparison with the norm, at 30 th day was decrease the amount of gap junctions per 100 μm intercalated disc in comparison of control level and caused predominantly violation build large gap junctions.
EPSTEIN-BARR VIRUS ROLE IN ONCOGENESIS
Authors: Shestakova I V , Yushyuk N D
Published: October 2016

We now recognize that the Epstein-Barr virus (EBV) plays a pivotal role in the development of some lymphomas and lymphoproliferative disorders that include B-cell, T-cell and NK-cell processes, and epithelial and mesenchymal tumors. While over recent years, EBV associated lymphomas are becoming increasingly recognized in patients without overt immunodeficiency. Improved understanding of the biology of these lymphomas and the role that EBV plays in their pathogenesis has paved the way for improved therapies targeted at critical signaling pathways as well as the development of novel cellular therapies. This review discusses the unique cytomorphology, clinical and immunophenotype signs and ancillary studies required to diagnose EBV-related neoplasms.
THE COURSE OF PREGNANCY AND CHILDBIRTH TAKING INTO ACCOUNT MEDICAL ACTIVITY AND DISPENSARY SUPERVISION OF WOMEN
Authors: Kabochkin A A
Published: October 2016

Results of sociological poll of 672 residents of Ryazan who had childbirth in the anamnesis are given in the article. Distribution of specific weight normal and pathological childbirth depending on the frequency of visit by respondents of female consultation with the preventive purpose to and during pregnancy is given. The results of an expert assessment of quality medical care for puerperants in such blocks as diagnostics, consultations of specialists, treatment and expertise of temporary disability are presented.
Changes in the hemostasis in patients with acute intestinal obstruction
Authors: Muraviev S Y , Fedoseev A V , Budarev V N , Amahanov A K , Allniazi A E
Published: October 2016

Acute intestinal obstruction is accompanied by changes in the hemostatic system. These changes are the deeper, the higher the degree of enteral insufficiency syndrome, concomitant obstruction. Orientation of the hemostasis shifts also depends on the severity of the syndrome. At the same time, the attempt to confirm statistically the correlation between hemostasis shifts and the severity of the enteral insufficiency syndrome failed. Consequently, the link between hemostasis shifts and processes in the intestine in patients with acute intestinal obstruction is indirect.
Organization of dental care residents of remote district of Ryazan area through outreach work in GBU PO "Dental polyclinic № 1»
Authors: Peshkov M V , Peshkov V A , Gurevich K G
Published: October 2016

One of the main tasks of the dental service is the maximum coverage of sanitation and preventive inspections of the population. National Population Census (2010) and the national epidemiological survey of dental population (2007-2008) showed 100% prevalence of dental caries in persons over 65 years, and nearly a third of the population (26,3%) live in the Russian countryside. To solve the problem of providing dental care to residents of remote areas where it is absent, organized a mobile dental office.
Computer users syndrome: psychometric methods in it complex investigation
Authors: Akhmadeev R R , Timerbulatov I F , Yuldashev V L , Bakirov L R
Published: October 2016

The article contains a survery of tests and questionnaries dealing with the following: psychometric investigation of the main aspects of computer user syndrome (CUS), visual fatigue; the nature and intensity of computer addiction, the basic parameters of computer users' mental health. The methods of the flexible battery is of special attention concerning its use within CUS research.
Operational research methodology material in ampullary carcinoma
Authors: Paklina O V , Setdikova G R , Shabunin A V , Bedin V V , Tavobilov M M
Published: October 2016

Indispensable key to successful diagnosis and treatment of cancer, including ampullary carcinoma is operating properly cut material for further histological examination. In this paper we present a modern algorithm for morphological study remote organocomplexes, which is designed to achieve the maximum objective morphological data at ampullary carcinomas.
Histological interpretation severity of dysplasia of connective tissue in clinical practice
Authors: Uhov U I , Sobennikov I S , Kotans S Ya , Cherenkov A A
Published: October 2016

In the article we make histological examination of the severity of dysplasia of connective tissue on the example of a microscopic examination of the aponeurosis of the external oblique abdominal muscles in patients with inguinal hernia and definition changes depending on the severity of the identified connective tissue dysplasia, defined clinically.
Modeling of severe hyperhomocysteinemia in rats
Authors: Medvedev D V , Zvyagina V I , Fomina M A
Published: October 2016

To date it’s proved that the elevated homocysteine levels in the blood is an independent risk factor for a number of diseases. The animal model of rare severe form of hyperhomocysteinemia may be necessary to study aspects of homocysteine participation in damage of organs and tissues in various diseases because the effects of this pathogenetic factor will be most pronounced in such conditions. This article describes a technique for modeling in male Wistar rats a severe form of hyperhomocysteinemia by a three-week intragastric administration of methionine suspension with the addition of this amino acid in the drinking water.
Patient evaluation of general practitioners as a tool to improve the quality of primary health care
Authors: Odrinskiy V A
Published: October 2016

In the experiment, on a model of acute carrageenin-induced inflammation of rat’s paw, changes in size of the affected limbs (paw edema), parameters of leukogram and activity of free radical oxidation were registered. The anti-inflammatory effect of antihypoxants (amtizol, hesperidin, hypoxen, metaprot) was investigated. It has been shown that hypoxen and metaprot 50 mg/kg have weak anti-inflammatory activity, but potentiate the effect of nonsteroidal anti-inflammatory drugs. At simultaneous enteral administration of hypoxen and metaprot with acetylsalicylic acid or diclofenac, evident anti-inflammatory effect was marked, that was manifested by significant reduction in registered inflammation symptoms.
Dynamics of tissue and ultrastructural changes in the embryonic heart of the chick embryo
Authors: Goodlett T A , Tverdokhleb I V
Published: October 2016

The analysis and comparison of histostructural and ultrastructural features of systole and diastole of the chick embryo heart at 29-46th stages on Hamburger, Hamilton were carried out. The main differences between the chambers of the embryonic heart by the nature of developmental dynamics of systolic and diastolic gradients, shows geometrical transformation of the walls of the chambers to reduce, described the features of the ultrastructure of sarcomeres, depending on the location of cardiomyocytes.
Medical and social aspects of reproductive image formation and behavior of adolescent girls of Kyrgyz Republik
Authors: Poltava N V
Published: October 2016

The analysis of the survey of 1016 adolescent girls living in Bishkek, Kara-Kol, Jalalabad, we found that in Bishkek 79,1% of adolescent girls living with one of the parents, that leads to earlier adulthood. In Jalalabad girls up to 18 years more likely lives in a civil marriage. In 95,4% teenagers take money from their parents. In Bishkek, girls were significantly more likely to buy cigarettes. There is no trust relations between teens and teachers. And modern teenage girls do not want to make judgment on their parents' secrets about reproductive behavior.
Obstetric and gynecological care in the Ryazan province in the late 18th -early 19th centuries
Authors: Kotova T A
Published: October 2016

The conditions of obstetric care to the population of Ryazan province in the late 18th - early 19th century was analyzed.
Social and demographic characteristics of female adolescents with alcohol addictive behavior
Authors: Muzhichenko V A , Kirpichenko A A , Kopytov A V
Published: October 2016

The authors have reviewed and identified most typical social and demographic characteristics of 14-18 year-old female adolescents from the Republic of Belarus who have had alcohol addicted behavior issues. Major social patterns associated with alcohol-addictive behavior have been identified and a social model of risk prediction has been developed for this group of patients. The findings may be useful for development of efficient targeted preventive arrangements.
Long-term results of balloon angioplasty for femoropopliteal artery disease
Authors: Zatevakhin I I , Shipovsky V N , Tursunov S B , Dzhurakulov Sh R
Published: October 2016

The article analyses the results of balloon angioplasty in patients with occlusive-stenotic lesions of the femoropopliteal arterial segment in the observation period up to 30 months. 95 patients underwent balloon angioplasty. Long-term results of primary patency was 43,1%.
Features of immune system at elderly patients after splenectomy in the next postoperative period
Authors: Maslyakov V V , Uryadov S E , Tabunkov A P
Published: October 2016

In order to investigate changes in the immune status of elderly patients after a splenectomy concerning an injury of a spleen researches of the immune status of 21 elderly patients which age from 60 to 80 years (the main group 1) after the injured spleen operations in the next postoperative period on the third - the fifth postoperative days was created. The group of comparison was made by 19 healthy elderly patients (group of comparison 2) and 19 patients of young and middle age (group of comparison 3). All patients had the isolated injuries of a spleen, easy volume of blood loss (to 500 ml). As a result of research it is established that at patients of advanced and senile age after a spleneetomy the following changes in the immune status of an organism in the next postoperative period are noted. In a cellular link - decrease in all analyzed indicators. In a humoral link - considerable decrease in indicators of IgG and M, FNOa, IL1ß, IL-6, INFγ and significant increase in the circulating immune complexes.
Long-term results of radical retropubic prostatectomy
Authors: Kaprin A D , Kostin A A , Filimonov V B , Vasin R V , Ivanova A Y
Published: October 2016

The results of a survey of the patients with a prostatic carcinoma, who have undergone a retropubic prostatectomy and a medical supervision within a maximum period of 9 years, are presented. The data about 94 patients with a prostatic carcinoma, who have undergone a retropubic prostatectomy and a pelvic lymphadenectomy in the time period since 2005 till 2013 in the Urology Department of SBO RR “RCH”, are retrospectively estimated. An average age of the patients was 63,5+7,8 years, a median of prostatic specific antigen is 11,6 ng/ml. Possessing the median of supervision as 44 months a biochemical recurrence is revealed in a total of 18 patients (19,1%) with the avarage time before its development 13 months. 5-years cancrispecific survival rate in D’Amico risk group terms in the postoperative period estimated as: 1) low - 100%, 2) intermediate - 94,4%, 3) high - 81,8% The most frequent delayed postoperative sequela were enuresis - 24,4% of the patients - within the period of 12 months after a retropubic prostatectomy performance, erectile dysfunction - 69,1% of the patients, stenoses of vesicourethral inosculation - 10,6% of the patients. Considering our data an erectile dysfunction after a retropubic prostatectomy performance occurred in 1,2 times more frequent after a retropubic prostatectomy performance without nerve tracts preservation. In the group of patients who have undergone a retropubic prostatectomy with a neck of urinary bladder, proximal and distal ends of urethra preservation, 16 (94,1%) patients are able to keep urine completely, in the group of patients who have undergone a retropubic prostatectomy without a neck of urinary bladder, proximal and distal ends of urethra preservation 46 patients (71,9%) haven’t got urinary incontinence. A retropubic radical prostatectomy revealed good results of oncological effectiveness among the patients with a prostatic carcinoma in a low risk group as well as in intermediate and high risk groups. Thorough selection of the patients who can undergo a retropubic prostatectomy with nerve tracts preservation, with a neck of urinary bladder, proximal and distal parts of urethra preservation makes it possible to improve the functional results of sergical operations without a loss of oncological effectiveness.
Reproductive behavior and reproductive health of adolescent girls of the Kyrgyz republic
Authors: Poltava N V
Published: October 2016

From results of voluntary anonymous survey conducted found that sexual debut among adolescent girls Kyrgyzstan held for 14 years in 42,3%, while 43,5% had pregnancy, 98,0% from them have interrupted data pregnancy. The mostly terminating pregnancies in Bishkek, using medical abortion. Endocrine pathology in adolescent girls is an average 48,0%.
The course and methods for predicting postpartum endometritis
Authors: Tuzlukov I I , Kovalenko M S , Naumova N V
Published: October 2016

Despite the advances of modem medicine, the problem of postpartum purulent-inflammatory diseases remains one of the most urgent in modern obstetrics. Currently, in the widespread use of antibiotics, due to changes in the nature and properties of the main pathogens in the clinical picture of chronic inflammatory diseases in the postpartum period is dominated erased, sluggish current form, which is characterized by impaired development of the pathological process. In this connection, the main focus is the prediction and prevention, as well as their early diagnosis. The criteria for predicting the development of inflammatory disease is frequently used data history, peculiarities of pregnancy and delivery. Definition of the functional state of neutrophils and their reserve capabilities can be used to predict the course of postnatal period and control of wound healing process.
Methodical approaches to research of problems of departmental healthcare
Authors: Fomin E P
Published: October 2016

Methodical approaches to the study of the modern state and problems of departmental healthcare are presented in this paper for central medical and sanitary part of closed administrative-territorial entity -Ozyorsk city. The characteristic of each stage of the research, indicating the sources of information used by the primary materials as well as expert evaluations of specialists are given.
Morphological changes of the liver parenchyma after embolization of the right branch of the portal vein
Authors: Shabunin A V , Grecov D N , Rakcha A P , Drozdov P A
Published: October 2016

To determine the morphological changes of the parenchyma of the right and the left lobe of the liver after embolization of the right branch of the portal vein. Material and Methods: Embolization of the right branch of the portal vein was performed in 15 patients. All patients by CT of the abdomen future liver remnant (FLR) sizes were less than 30% (from 17 to 27%) in average - 19,78%. Before and after the procedure was performed a biopsy of the right and the left lobe of the liver, followed by assessment of morphological changes of the parenchyma. Results: The volume of the liver after portoembolizatsii on average increased by 12,5%, the volume of the left lobe of the liver increased by an average of 41,7%. Expected hypertrophy of the left lobe of the liver is not obtained in one patient (6,66%). In the remaining 14 patients (93,3%) the size of the left lobe of the liver, and increased by more than 30%. Radical surgical treatment performed 9 (60%) patients. Study of histological changes after hepatic parenchyma portoembolization showed that hypertrophy of the contralateral lobe of the liver, occurs due to hypertrophy of the existing and the emergence of new, functionally active hepatocytes. The use of embolization of the right branch of the portal vein in most cases allows for vicarious hypertrophy of the left lobe of the liver due to hypertrophy of the existing and the emergence of new, functionally active hepatocytes.
Morphological and functional aspects of neurosecretory process in hypothalamic nuclei in heart failure
Authors: Papkov V G
Published: October 2016

V.G. Papkov Hypothalamus studied in 18 men who died from injuries, acute coronary insufficiency and congestive heart failure. In the supraoptic (SOY) and paraventricular (PVN) nuclei determined percentage neurocyte that are in various phases of neurosecretory cycle. Calculated the index of the functional activity of the nuclei. Revealed an uneven change in the ratio neurocyte that are in various phases of neurosecretion and index decreased functional activity of SOY in various forms of heart failure. The index of the functional activity of the PVN in acute coronary insufficiency remains on the "control" value. The observed changes are regarded as a morphological indicator of the regulatory function of the hypothalamus.
Oxidative carbonylation of proteins in muscle tissues with pronounced hyperhomocysteinemia
Authors: Ilicheva A S , Fomina M A
Published: October 2016

Oxidative modification of proteins (OMP) in myocardium, skeletal muscle and aortic wall in rats with pronounced hyperhomocysteinemia accompanied by increased formation of free radicals, which follows to developing of oxidative stress, was found. 8ignificant increasing content of dynitrophenylhydrasons principal at the expense of primary markers of oxidative stress (ADNPH) in experimental group was detected. It enable us to speak about persistence fragments of oxidativly damaged proteins in muscle tissue. Content of secondary markers (KDNPH) also increased. Development of intensive oxidative damage accompanied by additional formation of aggregated molecules and also weakness of reserve -adaptative potential all investigated muscle tissues were shown.
Comparative characteristics cultural properties of adherent cells derived from bone marrow of multiorgan donors and tissues donors
Authors: Hubutija M Sh , Ponomarev I N , Konjushko O I , Makarov M S , Borovkova N V
Published: October 2016

Purpose of work - compare cultural properties of adherent cells derived from bone marrow of multiorgan donors and tissues donors, to assess the possibility of using these cells in clinical practice. Materials and methods. Adherent culture cells from cadavers bone marrow were obtained using standart methods of isolation, scaling, and passaging cells. In culture, counted the number of CFU-F, proliferating activity of cell , their complies with the minimal criteria for defining multipotent mesenchymal stromal cells (hMSC) and compatibility with allogeneic tissue grafts. The Results. In cultures of cells derived from multiorgan donors and tissues donors the number of CFU-F was 0,0004% and 0,00024%, while the duration of the phase "rest proliferative" was 3-4 and 10-12 days respectively. All examined cell culture after the second passage have gained a high degree of homogeneity, and the cells were complies the minimum criteria hMSC. Conclusion: bone marrow of multiorgan donors and tissues donors can be used for obtain hMSC, suitable for creating a combined cellular-tissue grafts for clinical use.
Glycaemia monitoring and clinicoinstrumental studies in diabetic neuropathy diagnostics
Authors: Dubinina I I , Zhadnov V A , Berstneva S V , Baranov V V , Azimkova L V
Published: October 2016

The article presents the results of the study of glycaemia variability, neurological symptoms and electroneuromyography indicators in 33 patients with diabetes mellitus type 2 and diabetic neuropathy, who, at the moment of the study, received various kinds of antihyperglycemic therapy. Significant increase of the glycaemia coefficient after combined perioral therapy was found. Correlation dependency of positive neurological semiology, neurological deficiency and electroneuromyography data (M-response amplitude, propagation rate of activation and residual latency) upon the level of glycated hemoglobin (HbA1c), standard deviation and glycaemia variability coefficient was found.
THE WAYS OF OPTIMIZATION OF LARYNX CANCER PREVENTION AMONG THE POPULATION OF THE REGION
Authors: Luzhetsky V A , Soloviev V I , Dubovoy I I , Pugach L I
Published: October 2016

The comprehensive study on the prevalence of risk factors for malignant neoplasms of the larynx among the population was done. The screening test was proposed and a mathematical-statistical model to determine the probability of individual risk of larynx cancer was created. "The methodology of forming high-risk groups in the incidence of malignant neoplasms of the larynx and organization of the dispensary supervision" was done, which allows to improve the quality of the preventive and clinical work with the population.
COMPREHENSIVE ULTRASOUND ASSESSMENT OF THE FETAL CEREBELLUM IN THE SECOND TRIMESTER OF PREGNANCY
Authors: Kozlova O I
Published: October 2016

Fetal brain was retrospectively evaluated in normal fetuses at 16-27 weeks of gestation, obtained by multiplanar echography. In axial cerebral plane was measured transverse cerebellar diameter. All measurements were done from as the widest diameter across both hemispheres in an outer-to outer fashion. In mid-sagittal plane was measured craniocaudal diameter and anteroposterior diameter of the cerebellar vermis. Craniocaudal diameter was defined as maximum distance between cranial and caudal surfaces of the vermis, anteroposterior diameter was defined as the maximum distance between anterior and posterior surfaces of the vermis. Normal range plotted on the reference range of the transverse cerebellar diameter, craniocaudal diameter and anteroposterior diameter of the cerebellar vermis. Measuring of its size may be useful for comprehensive ultrasound assessment of the fetal cerebellum in the second trimester of pregnancy.
COMPARATIVE CHARACTERISTIC OF THE PREGNANCY AND DELIVERY AT THE PATIENTS AFTER PREVIOUS SURGERIES ON A UTERUS
Authors: Devyatova I N , Malakhova O M , Kharkevich O N
Published: October 2016

The complex analysis of indications to cesarean delivery in the Ryazan Regional Clinical Perinatal Center during 2011-2013 is carried out. Frequency of cesarean delivery was 32.8%. Earlier undergone surgeries on a uterus made 26,4% in structure of all indications to cesarean delivery. Results of research showed that conservative conducting childbirth at pregnant women after the undergone surgeries on a uterus is an essential reserve of decrease in number of cesarean delivery. The main conditions of conservative conducting childbirth: anatomic and functional quality of a uterus; clinical compliance of the sizes of a fetus and woman's pelvis; absence of absolute contraindications to childbirth from mother and fetus.
NEW ASPECTS IN STUDYING OF PARATHYROID MORPHOLOGY AS A CONDITION FOR PARATHYROIDECTOMY TECHNOLOGY OPTIMIZATION UNDER INTEGRATED APPROACH
Authors: Krayushkin A I , Zagrebin V L , Perepelkin A I , Barkanov V B , Zubkov A V
Published: October 2016

The article provides information about the topography and morphology of the parathyroid gland depending on sex, age and ethno-territorial somatotypological features. Establishing of relations between shapes, sizes with topography and morphological parameters of parathyroid gland allow to predict the location of the parathyroid gland before operation, and therefore to optimize the performance of operations on the thyroid and parathyroid glands.
ANALYSIS OF NATIONAL LEGISLATION RELATIONS IN PARTS OF THE PROCESSING OF PERSONAL DATA IN THE HEALTH SERVICE
Authors: Korneeva O I
Published: October 2016

The paper presents an analysis of the existing national legislation regulating relations in the part of the processing of personal data in the activities of medical institutions - the Federal Law «On personal data» of 27.07.2006 № 152-FZ, Federal Law «On Compulsory Health Insurance in the Russion Federation» dated 29.11.2010 № 326-FZ and the Federal Law of the Russion Federation» «On the basis of health protection in the Russion Federation» dated 21.11.2011 № 323-FZ.
CHANGES IN THE CONTRACTILE CARDIOMYOCYTES AND HEMOMICROCIRCULATORY BED IN PREGNANT RATS AND THEIR PUPS EXPOSED TO HEMIC HYPOXIA
Authors: Zadnipryany I V , Tret'yakova O S , Sataieva T P
Published: October 2016

The performed analysis of the morphology of cardiomyocytes and myocardial vascular bed in 12 pregnant rats and 16 newborn pups exposed to the hemic hypoxia induced by NaNO 2 revealed some similar degenerative and destructive changes which were more pronounced in pups. The main morphological characteristics of hypoxic myocardial damage in pregnant and newborn rats were presented in the form of phenomena of mixed dystrophy, swelling and destruction of endothelial cells and contractile cardiomyocytes along with the lysis of myofibrils, perivascular edema, capillary hyperemia, emptiness and spasm of the arterioles and contracture changes. Revealed pathological changes in the myocardium reflect the development of the myocardiodystrophy processes in pregnant rats and newborn pups.
ROLE OF VASCULAR FACTOR IN THE PATHOGENESIS OF REMOTE CONSEQUENCES OF DEFORMING ARTHROSIS OF THE ANKLE JOINT
Authors: Mombekov A O , Dergunov A V , Davydov V V , Toriya V G , Umantsev E I , Zuhrabov Z K
Published: October 2016

A comprehensive assessment of hemodynamics of blood vessels, lower leg in patients at different times, the late period of deformative arthrosis of the ankle joint (DAGS) according to the gravity, which allows to predict its course, outcomes and identify the occurrence of complications were carried out. Dynamic monitoring of patients contributed to the high efficiency of the differentiated approach to the management of each category of patients in the long term DAGS was made. The authors have obtained information that the outcome depends on the violation of vascular autoregulation leg hemodynamics in different periods of deforming arthrosis of the ankle joint of any severity. Identified data provide an opportunity to optimize a differentiated approach in the treatment of patients with distant periods of follow-up monitoring.
INFLUENCE OF PHYSICAL ACTIVITIES ON MORPHOMETRIC PARAMETERS OF THE MESENTERIC AND SUBCUTANEOUS TISSUE OF RATS WITH OBESITY, HIGH-FAT DIET INDUCED
Authors: Yakimovich I Yu , Borodin D A , Podrezov I K , Ivanov V V , Vasilyev V N , Kotlovsky M Yu , Borisova L V
Published: October 2016

White adipose tissue (WAT) distribution (visceral fat predomination) and amount (adipose cell hypertrophy) may be a crucial risk factor of metabolic disorders. Present study shows effects of aerobic and anaerobic exercises on morphometric characteristics of mesenteric and subcutaneous WAT in hi-fat diet induced obese rats. The study found that animals, received hi-fat diet, demonstrate prevalence of small-size adipocytes. Probably it protects ectopic tissues from lipotoxic effects. Anaerobic physical exercises reduce amount of mesenteric WAT in normal rats received standard chow. Applied with hi-fat diet, anaerobic physical exercises reduce amount and size of fat cells in mesenteric WAT, but aerobic physical exercises reduce the same characteristics in subcutaneous WAT.
SCREENING EVALUATION OF HARMONIOUS DEVELOPMENT OF GIRLS’ SKELETON
Authors: Lopatina L A , Sokolov D A
Published: October 2016

The study of anthropometric parameters and indexes in groups, formed according to the canon of proportionality, was carried out. Three groups were formed, which differed significantly from each other. In most of 68,5% of the examined students the ontogenetic maturation was completed. In 31,5% of girls, whose arm span exceeded growth, the proportions are able to be changed under the influence of external and internal factors. A simple and affordable approach, proposed by us, allows to carry out the screening of body harmony and to estimate the completion of the growth processes.
EFFECT OF THE POLYSACCHARIDE COMPLEX OF AMELANCHIER VULGARIS ON MORPHOPHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS OF LABORATORY RATS
Authors: Laksaeva E A , Sychov I A
Published: October 2016

Experimental facts of this article show, that the soluble polysaccharide complex of Amelanchier Medic (Amelanchier vulgaris) induces erythropoesis by increasing the level of erythrocytes and hemoglobin in blood of experimental rats and changes the level of lymphocytes, leucocytes and monocytes. The following changes occur in blood of the experimental animals: increase in the level of iron and iron-binding properties of serum as well as a change in the level of protein fractions. Polysaccharide of Amelanchier Medic (Amelanchier vulgaris) causes increase in the mass of spleen and decrease in the mass of thymus increases of physical activity of experimental animals.
TENDENCIES OF MENTAL HEALTH IN POPULATION OF RYAZAN REGION UNDER REFORMS IN PSYCHIATRIC SERVICE
Authors: Landyshev M A , Petrov D S
Published: October 2016

In the article the complex analysis of indices of mental health in population of Ryazan region for 2003-2013 years has been presented. The tendencies of changes of statistic data in the region as compared to the information around Russia has been estimated. Negative tendencies of population’s mental health indices, decrease of primary detection of mental disorders have been found.
WORK EXPERIENCE REDUCED MORTALITY OF CHILDREN AND ADOLESCENTS IN SAMARA REGION
Authors: Shmelev I A , Konovalov O E
Published: October 2016

Lower infant mortality rates, which is an important component of mortality of children under 14 years were noted in the Samara region 2004 to 2011 compared to the Volga Federal District and the Russian Federation. It was stated that the reduction in mortality of children in the age group of 1 to 4 years due to the decrease in its rates from malignancies, congenital malformations and external causes. Measures to improve the health of children and adolescents implemented within the framework of regional target programs and projects are also considered in the article.
REGIONAL FEATURES OF DERMATOGLYPHICS IN PHYSICAL HEALTH MEN WITH CARIES OF LOW INTENSITY LEVEL
Authors: Borisenko A V , Shinkaruk-Dykovytska M M
Published: October 2016

Discovered some, mostly solitary, differences in administrative-territorial distribution of dermatoglyphic signs for somatically healthy men first mature age with low intensity of caries that it is not possible to distinguish dermatoglyphic complexes typical, for a given level of intensity of caries, for a specific region of Ukraine. Dermatoglyphics differences at low intensity of caries in the direction of the west↔south are regarded by us as a manifestation of populational-regional characteristics of the gene pool of Ukrainians male that fulfill the criteria of complete physical health
EFFECT OF AN INHIBITOR OF DPP-4-VTLDAGLIPTIN FOR THE FUNCTIONAL ACTIVITY OF P-GLYCOPROTEIN IN VIVO
Authors: Titov D S , Nikiforova L V
Published: October 2016

In the in vivo study in rabbits the effect of vildagliptin at 5 mg / kg body weight of the functional activity of the protein transporter P-glycoprotein (P-gp, ABCB1 protein) was studied. P-gp activity was evaluated by its pharmacokinetics marker substrate - fexofenadine after a single intragastric administration. Applying vildagliptin for 14 days led to an increase in the maximum concentration of fexofenadine, its half-life, area under the concentration-time curve from zero to the last point of drawing blood, area under the concentration-time curve from zero to infinity, and the retention time of marker substrate and reduce the overall clearance rate of absorption and distribution volume, indicating that the inhibition of the functional activity of the protein transporter at the level of the whole organism.
RESULTS OF 5-YEAR OBSERVATION FOR PATIENTS WITH HEART DISEASE
Authors: Petrov V S
Published: October 2016

The article presents the five-year dynamics of patients with rheumatic heart disease, changes in echocardiographic indicators, quality of life and the course of chronic heart failure. It was found that the negative dynamics of the echocardiography indicators does not lead to progression of heart failure and a significant deterioration in the quality of life of patients. Cases of a combination of type II diabetes, atrial fibrillation, severe mitral stenosis, left atrial dilation lead to an increased risk of death in patients with rheumatic heart disease.
MORPHOMETRIC PARAMETERS OF MAXILLARY PARODONT VESSELS IN PATIENTS WITH INTACT DENTAL ARCH AND TOTAL ADENTIA
Authors: Andreeva І V , Volikov V V
Published: October 2016

Histology of the bone preparations of maxillary alveolary process of 20 human beings. The age of corpses corresponded to mature, elderly and senile age periods. 20 corpses were 12 (60%) men and 8 (40%) women. The expressed changes pronounced changes of morphometric parameters of the maxillary parodont vessels were revealed in patients with full adentia of the maxilla. A quantity of vessels in 1 mm 2 was less in 60%, diameter of vessels was less in 70%, thickness of vessel wall was more in 4 times in patients with total adentia in comparison with the patients’ group with intact dental arch.
A new method of making drug on the wound surface with direct tooth-jaw prosthesis. Clinical and experimental research
Authors: Kharitonov D Yu , Mitin N E , Grishin M I
Published: October 2016

This article analyzes the ways of making medicines on the wound surface in the tooth-jaw prosthesis. Creating original retention points on the basis of dentoalveolar prosthesis optimizes leaching and absorption medicinal components that lead to the preservation of their therapeutic concentrations. The research will help to solve the important problem of efficiency and speed postoperative rehabilitation.
About the necessity of forming a motivation to a healthy way of life and going in for sports at students of medical institutes of higher education
Authors: Proshlyakov V D , Nikitin A S
Published: October 2016

This article is devoted to the investigation of a degree of training of junior students of Medical University, discovering the reasons of their lower motivation and forming their interest to a regular physical activity. It is found that a lower degree of training of junior students is a result of school educational process of low quality. It may be raised to the proper level by drawing students into participation in mass sport competitions. It will lead to the formation of their positive motivation to going in for sports.
Genetic aspects of ischemic heart disease
Authors: Pakhomia N S , Uryasev O M , Panfilov Y A
Published: October 2016

The article contains a review of the contemporary status of the problem of genetic aspects in ischemic heart disease. Provided are results of studies of candidate genes role in the development of ischemic heart disease - the gene for lipoprotein lipase, the gene for nitric oxide synthase - 3 and the gene for angiotensinogen. Attention of the polymorphism of these genes is due to their prognostic importance and close relationship to several risk factors of development and progress of cardiovascular diseases.
Suicidal behavior: the role of "foreign key", as an element of the suicidal dynamics and object of psychotherapy
Authors: Zotov P B
Published: October 2016

The commission of a suicide attempt is usually not random in nature. The program start is only possible if the actualization of some external characteristic / event that the suicide of the highlights in the subjectively meaningful factor is «foreign key». It is noted that before the trip a «foreign key» suicidal action unlikely, and if it needs updating - is almost inevitable. It is noted that the list of these entities is usually specific to certain risk groups. Examples of foreign key in adolescents and patients with malignant tumors. Identification of «foreign key» requires consideration by the doctor as an object of psychotherapy to prevent suicide.
3-(2,2,2-trimethylhydrazinium) propionate: the role of ATP-dependent potassium channels in cardioprotection effect
Authors: Pokrovsky M V , Danilenko L M , Tatarenkova I A
Published: October 2016

The work evaluated the influence of 3-(2,2,2-trimethylhydrazinium) propionate per square necrotic myocardium of the left ventricle and the level Troponin I serum during acute coronary occlusion (60 minutes) followed by reperfusion (90 min) in anesthetized rabbits. It is shown that distant and pharmacological preconditioning 3 (2,2,2-trimethylhydrazinium) propionate reduce necrosis zone 3 and 1,5 times, respectively. Found participation ATP dependent potassium channels (K-ATР channels) of endothelial and inducible NO-synthase in the implementation of the cytoprotective effect of distant preconditioning and 3-(2,2,2-trimethylhydrazinium) propionate, indicating that the implementation of the mechanism of pharmacological preconditioning in his cardioprotection action.
Effect of gliquidone on the ABCB1 protein functional activity in vivo
Authors: Titov D S , Nikiforov A A , Pravkin S K
Published: October 2016

In the in vivo study in rabbits the effect of gliquidone at 10 mg / kg body weight of the functional activity of the protein transporter P-glycoprotein (P-gp, ABCB1 protein) was studied. P-gp activity was evaluated by pharmacokinetics of its marker substrate - fexofenadine after a single intragastric administration. Applying gliquidone for 14 days led to an increase in the maximum concentration of fexofenadine, its halflife, area under the concentration-time curve from zero to the last point of drawing blood, area under the concentration-time curve from zero to infinity, and the retention time of marker substrate and reduce the overall clearance and rate of absorption, indicating that the inhibition of the functional activity of the protein transporter at the level of the whole organism.
P-glycoprotein expression in brain during ischemia-reperfusion
Authors: Yakusheva E N , Chernykh I V , Shchulkin A V , Vinogradov I Yu
Published: October 2016

On wistar rats expression of P-glycoprotein in the brain after unilateral occlusion-reperfusion of the common carotid artery was studied. Correlation between the expression of the transporter and redox status of the brain cerebral cortex was assessed. Occlusion was simulated under ether anesthesia by common carotid artery clamping using vascular clamp for 180 minutes followed by recanalization. Samples of cerebral cortex were taken after 60 min, 4 h, 24 h, 5 days and 14 days after reperfusion and subjected to standard immunohistochemical processing, as well as evaluating the redox status. It was revealed that the 180-minute occlusion of unilateral common carotid artery followed by reperfusion causes a decrease in the expression of P-glycoprotein after 60 min and 4 hours after reperfusion by 52,5% и 63,1% (p0,05) respectively. P-glycoprotein expression is conversely related with the level of TBA-reactive species.
Psychological research genesis vital metacompetence of personality
Authors: Yakovleva N V
Published: October 2016

The article discussed the formation of health-research activities in line with the personality of the author's concept of vital metacompetence. The relationship formation vital competencies with age laws of formation of the person has been demonstrated. Based on empirical data were identified sensitive periods for the formation of vital skills.
ULTRASOUND ASSESSMENT MIDLINE STRUCTURES OF THE FETAL BRAIN IN THE SECOND TRIMESTER OF PREGNANCY: CORPUS CALLOSUM
Authors: Kozlova O I
Published: October 2016

Fetal brain was retrospectively evaluated in normal fetuses at 18-27 weeks of gestation, obtained by multiplanar echography. Most useful for assessment normal development of the corpus callosum measurement length of the corpus callosum. The multiplanar mode to obtain the mid-sagittal plane and measured length of the fetal corpus callosum from the most anterior aspect of the genu to the most posterior aspect of the splenium. Normal range plotted on the reference range (mean, 5 th and 95 th percentiles) of length of the corpus callosum, may be useful for assessment development of the corpus callosum in cases of suspicion on cerebral anomalies like hypoplasia, partial agenesis of the corpus callosum.
Autoaggressive characteristics of women who are married to men who suffer from alcoholism
Authors: Merinov A V , Shitov E A , Lukashuk A V , Somkina O Y
Published: October 2016

Research is devoted to the study of auto-aggressive activity of the wives of men suffering from alcoholism, as well as the influence of the phenomenon under study in the clinical and a suicide, experimental psychological and co-dependent indicators of the respondents. Studied phenomenology parasuicide studied groups of women. These data substantially expand the existing theoretical concepts of auto-aggressive orientation inherent in the studied group of respondents, as well as significantly enrich the implementation of practical ways to reduce «a suicide tension» this, widespread in the world, a group of women.