bluuebunny/crossref_metadata_2025 huggingface dataset:
Theorie-Praxis-Integration im Journalismusstudium
Authors: Franze Marcel , Ollrog Marc-Christian
Published: June 2024

Wie das Erlernen von theoretischem Wissen und praktischen Fähigkeiten verbunden und verschränkt werden soll, ist eine Kernfrage in Journalismus- und Journalistikstudiengängen. Die Integration der beiden Elemente wird als entscheidendes Bildungs- und Ausbildungsversprechen gesehen (Bergmann und Pörksen 2007, 18). Diese Studie untersucht, inwiefern die Studiengänge in Deutschland bei der Ausbildung der Studierenden einem gemeinsamen Muster der Theorie-Praxis-Integration folgen. Hierfür wurden durch eine qualitative Inhaltsanalyse zehn Modulhandbücher von Journalismus- und Journalistikstudiengängen mit dem von Wolfgang Streitbörger (2014) entwickelten Analyseraster untersucht. Die Anwendung des Analyserasters auf die Modulhandbücher stellt gleichzeitig einen erfolgreichen Machbarkeitstest dar, da es eigentlich dafür ausgelegt ist, die ganze Struktur eines Modulhandbuchs zu untersuchen. Hier wurde es dazu verwendet, einzelne besonders integrative Lehrveranstaltungen und Module in den Curricula zu identifizieren und zu gruppieren. Insgesamt wurden 34 Module und Lehrveranstaltungen identifiziert, die als besonders integrativ eingeordnet werden konnten und in vier Gruppen gegliedert wurden. Die erste Gruppe bilden Module und Lehrveranstaltungen, in denen Medienpraxis simuliert wird, bspw. die Lehrredaktion. Die zweite Gruppe bilden Module und Lehrveranstaltungen, in denen kreativ mit Computerprogrammen im Rahmen von Projekten gearbeitet wird. In der dritten Gruppe wird interdisziplinär bzw. gemeinsam mit externen Disziplinen gearbeitet. Die vierte Gruppe beinhaltet kommunikationswissenschaftliche Module und Lehrveranstaltungen, in denen empirische Projekte umgesetzt werden. Abschliessend wurden die Ergebnisse der Inhaltsanalyse durch einen Literaturabgleich mit den Idealvorstellungen deutscher Journalismusforscher:innen zur Theorie-Praxis-Integration abgeglichen, um Gemeinsamkeiten und Divergenzen festzustellen.
Study on numerical simulation and mitigation of parametric rolling in a container ship under head waves
Authors:   College of Ocean Science and Engineering, Shanghai Maritime University, Shanghai, 201306, China, Liang Liu , Baoji Zhang , Hao Zhang , Jiaye Gong , Zheng Tian , Shuhui Guo , Yuanbiao Bao , Xu Zheng ,   Merchant Marine College, Shanghai Maritime University, Shanghai, 201306, China
Published: June 2024

To investigate the parametric rolling motion of container ships navigating in head seas, this study utilizes the unsteady RANS approach combined with dynamic overlapping grid technology to simulate parametric roll in a container ship under the coupled motions of roll, pitch, and heave. Initially, the model was validated against experimental results, demonstrating good agreement and thus confirming the reliability of the computational method. Furthermore, the paper investigates the impacts of the initial roll angle, encounter frequency, and the addition of bilge keels on parametric rolling. The research findings indicate that the initial angles of rolling impact the duration needed to attain a steady roll condition, yet they have minimal effect on the amplitude post-stabilization. The likelihood of parametric rolling arises when the frequency of encounters doubles that of the ship's inherent roll frequency. Furthermore, the likelihood of parametric rolling escalates when the wavelengths approach the length of the ship. Installing bilge keels markedly reduces the parametric rolling movement in vessels, and the occurrence of parametric rolling is also delayed.
Managing Emotional Intelligence of Construction Players During COVID-19 in Malaysia
Authors:   School of Construction and Quantity Surveying, College of Built Environment, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, MALAYSIA, Mohd Fateh Mohd Ashraf , Supian Ainun Najwa ,   School of Construction and Quantity Surveying, College of Built Environment, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, MALAYSIA, Goh Cheng Siew ,   Faculty of Architecture and Built Environment, Northumbria University, Newcastle upon Tyne, NE1 8ST, UNITED KINGDOM
Published: June 2024

Construction players are expected to be high in emotional intelligence to provide the best quality services. However, there are still gaps that exist between emotional intelligence and construction players, especially with the current issue that they have experienced during the pandemic phase. The objectives of this study are: (1) to investigate the issues that affect the project’s success during the pandemic coronavirus disease 2019 (COVID-19), (2) to evaluate the current emotional intelligence of construction players during the pandemic and (3) to analyse the emotional intelligence factors of construction players during the pandemic. This study utilised a quantitative approach with Trait Emotional Intelligence Questionnaire (TEIQue) statements in gathering the data from the relevant construction players. A total of 108 respondents participated in this study. The collected data was analysed using mean, standard deviation and percentage analysis. The findings reveal that construction delays were the main project performance problem in Malaysia during the pandemic. Anxiety was the main emotion that affected the construction players during the pandemic, hitting heavily on the male respondents. Self-control was highlighted as the main emotional intelligence factor and the most important trait of construction players. The benefit of this study is that it can be used as a way of handling projects in the context of emotional intelligence for the construction players, which is in line with Sustainable Development Goal 8 (SDG 8) which is about decent work and economic growth.
Participación ciudadana en la política pública de deporte en Medellín
Authors: Zapata Cortés Olga Lucía
Published: June 2024

¿Cuál es la incidencia de la participación ciudadana en la formulación de políticas públicas locales? Este artículo de reflexión responde, exploratoriamente, esta pregunta desde el caso de la política pública del deporte, la recreación y la actividad física en Medellín. Teniendo en cuenta el mismo método, instrumentos e información recolectada durante el proceso original de reformulación, se contrasta esta información con la incorporada en los documentos oficiales que recogen la actualización de la política pública. Aunque se invoca la metodología de co-creación, se mantienen los mismos canales y limitaciones a la participación ciudadana; entonces, se participa, pero no se co-crea.
Una reflexión multimodal sobre los contenidos educativos construidos en imagen y video en el marco de una propuesta educativa para la salud
Authors: Vásquez Velásquez Ana Maria , Bolívar Buriticá Wilson , Castaño Pineda Yeferson
Published: June 2024

Cuando los procesos de construcción de contenidos digitales se producen con escaza participación de la comunidad, las decisiones sobre el significado pasan por la interpretación de técnicos y profesionales expertos que tienen otra lectura del mundo y en algunos casos se termina en procesos de exclusión desde el mismo significado que se presenta. Debido a la toma de decisiones que surge entre una temática y el modo que se elige, se presenta como reto una participación amplia de las comunidades para crear contenidos formativos en el marco de la Educativos para la Salud (EpS).
Competencias sociales, emocionales e interculturales como parte fundamental del perfil integral de estudiantes de pregrado
Authors: Alvarez Johny Antonio , Yepes-Zuluaga Sara María , Montes-Granada Willer Ferney
Published: June 2024

En el perfil profesional de los programas educativos de todas las disciplinas se señala que las competencias de los estudiantes universitarios tendrán que reflejar sus conocimientos, capacidades y habilidades para operar en un mundo más interconectado globalmente. Las competencias Sociales y Emocionales, como parte fundamental del ser y de la memoria social dan a los estudiantes de pregrado un punto de partida para su formación y al mismo tiempo influye en la constitución de la inteligencia Intercultural que le permitirá al futuro profesional desempeñarse en un contexto global, como parte fundamental del perfil integral.
Aproximación a los factores predisponentes a la deprivación sociocultural en los ámbitos familia, escuela, comunidad
Authors: Narvaez Jonnathan , Obando Guerrero Lina Maria , Montero Acosta Diana Carolina
Published: June 2024

El presente artículo presenta los factores predisponentes a la deprivación sociocultural en escuelas públicas en los ámbitos familia, escuela y comunidad. Los resultados evidencian que la dimensión apoyo social comunitario presenta los niveles más altos y la dinámica familiar los más bajos. Asimismo, se presenta un marco expositivo que relaciona la escuela, familia y comunidad como factores predisponentes a la deprivación sociocultural. El abordaje metodológico fue de un estudio mixto de prevalencia cualitativa. En la primera fase se empleó el método cuantitativo, de tipo descriptivo y transversal y en la fase cualitativa se utiliza un enfoque biográfico narrativo.
Violencia intrafamiliar en Colombia en los últimos doce años
Authors: Restrepo Betancur Luis Fernando
Published: June 2024

La presente investigación consiste en evaluar y comparar estadísticamente el número de casos de violencia intrafamiliar en Colombia entre los años 2010- 2021, con base en los reportes de la Policía Nacional. La base de datos está compuesta por 896.017 casos de violencia denunciados. Se empleó distribución de frecuencias, análisis comparativo por el método GLM y proyección Biplot. Cundinamarca diverge estadísticamente respecto a las demás regiones evaluadas, donde las mujeres presentan el mayor porcentaje de violencia intrafamiliar. Factores como las restricciones de movilidad, la incertidumbre, el estrés entre otros componentes, son la raíz de situaciones complejas familiares.
Ideal Pedagógico, Religioso, Social y Ecológico de San Francisco de Asís
Authors: Echeverri H Fray Joaquín Arturo
Published: June 2024

En torno al ideal Pedagógico, religioso, social y ecológico de San Francisco de Asís se congregaron, para compenetrarse de él, no solo sus discípulos, sino el mundo de su época hasta nuestros días. Es lo que podría llamarse el triunfo del amor y del ideal. Su propuesta de vida, despertaron no solo la admiración, sino que se constituye en una propuesta para hacer frente a una aguda crisis civilizatoria hoy.
Tensiones y posibilidades del investigador educativo colombiano: de la disolución mercantil a la defensa del deseo de saber
Authors: Cuesta Moreno Óscar Julián , Cabra-Torres Fabiola
Published: June 2024

El artículo expone elementos históricos que han incidido en la configuración de la investigación educativa en Colombia en las últimas décadas para mostrar de qué forma tal contexto ha influenciado en el investigador educativo. En primer lugar, describe vacíos presentes en los trabajos de investigación en educación. Desde allí, el análisis se centra en la universidad contemporánea y los efectos que ha tenido el capitalismo cognitivo y la mercantilización en estas instituciones que son uno de los escenarios donde se efectúa investigación educativa. En un tercer momento, muestra la incidencia de la lógica mercantil en la formación de investigadores educativos. Finalmente, el artículo propone elementos para tensionar el campo e incidir en la formación de los futuros investigadores y en las prácticas de los investigadores vigentes, de tal manera que se logre una reorientación de los parámetros que determinan al campo educativo.
Factores que intervienen en el desempeño de los estudiantes en las Pruebas de Estado Saber Pro
Authors: Demarchi Sanchez Geydi Dahiana
Published: June 2024

Las pruebas Saber Pro son evaluaciones estandarizadas que miden al estudiante con relación a su proceso formativo, pero en ocasiones se cree que los resultados solo se deben a asuntos académicos. Esta investigación busca identificar los factores que afectan el desempeño de las personas en las pruebas de Estado Saber Pro. La metodología empleada es cualitativa, la técnica para recoger información fue la entrevista y la encuesta. Como conclusión se dice que, el estudiante se encuentra influenciado por múltiples escenarios como la familia, lo laboral,la situación económica y el barrio como escenarios próximos donde habita que interfieren en sus resultados de las pruebas.
La memoria como práctica mediática discursiva frente a la reparación simbólica y la ley de víctimas
Authors: Arrubla Sánchez Ricardo , Saavedra Espitia Camilo
Published: June 2024

El artículo aborda las diferentes perspectivas de opinión que se difunden en la Web entorno a la memoria, la reparación simbólica de las víctimas y frente a la Ley 1448. Tiene por objetivo analizar los núcleos conceptuales y de significado presentes en los diferentes documentos seleccionados.
El Cuidado de Sí desde una Perspectiva Relacional
Authors: Roll López Samuel
Published: June 2024

El cuidado de sí no es una capacidad que el individuo adquiere de manera aislada o con el simple paso de una edad a otra, sino que se origina en un contexto relacional temprano y, como tarea del desarrollo, constituye un hito importante de cara al establecimiento de relaciones maduras en la adultez.
Saber pedagógico e investigación narrativa
Authors: Barrera Quiroga Diego Mauricio
Published: June 2024

La formación docente, la investigación educativa, las relaciones pedagógicas y el saber articulan una compleja discusión que, en particular, pueden estar mediada por la “narrativa pedagógica”; es decir, un método que nos ayuda en la indagación por la acción docente y la experiencia pedagógica. Esto con el fin de descubrir interrogantes que nos conduzca a potenciales producciones “colaborativa[s] de saber pedagógico, la reconstrucción de la memoria pedagógica de la escuela y la transformación de las prácticas educativas” (Suárez, 2011, p. 17). Este dispositivo de transformación centra su atención en los relatos de experiencia docente que pregunta, relacionan, participan, focalizan y construyen estrategias para la indagación y reflexión a través de las narrativas.
Acceptance of Sexual and Gender Minorities through Romance TV Drama Series with LGBT Characters: The Voices of College Students in Thailand
Authors:   Faculty of Literature, Taisho University, Tokyo, Japan, Amaki Yuki
Published: June 2024

This study focused on the views of 77 current college students in Thailand on gay-related romantic TV dramas and their social impact. The survey aims to determine how gay-related romantic dramas affect the understanding of and discrimination against LGBTQ+ people in Thai society and to propose solutions based on the results. The survey results suggest that gay-related romantic dramas may have an impact on social perceptions and tolerance toward LGBTQ+ people. Positive opinions emphasized that the dramas promote understanding between different generations and cultures and provide opportunities to accept LGBTQ+ identities. On the other hand, negative opinions expressed concern that the dramas are removed from reality and do not adequately reflect the real situations and issues of LGBTQ+ people. Based on these findings, this study provides valuable suggestions for improving LGBTQ+ public awareness and understanding. These recommendations aim to enhance public awareness and comprehension of LGBTQ+ matters, with the understanding that the students’ voices are crucial in this process.
Dominant Language, Urbanization and Lexical Depletion of Native Language: A Corpus Linguistics Study
Authors:   Associate Professor, Shiv Nadar Institution of Eminence, Sharma Gatha
Published: June 2024

India is home to hundreds of languages. Each Indian language is unique and an identity marker for individuals, communities, and their culture. The English language, though not native to India, has a significant presence in this vast country. One hundred and ninety years of British colonial rule over India had established English as the ‘dominant language’ in the country long ago. Rapid urbanization; and the consequent proliferation of telecommunication networks have further increased its dominance over Indian languages in the last few decades. The heavy code-mixing of English words in the Indian languages is reducing the richness of the vocabulary of the Indian languages by replacing their words with English words, thereby initiating ‘lexical depletion’ based language change in the native languages. This paper is an empirical study to map the code-mixing of English words in the Hindi language and its impact on the Hindi language, as observed in Greater Noida, a town that has seen rapid urbanization since 1991. This paper attempts to explain the implications of code-mixing on the Hindi lexicon by analysing a corpus of spoken language data using corpus-linguistics and computational linguistics methodologies.
Data management and quality control
Authors: Auger S. , Besnier J.-B. , van Bijnen M. , Cherqui F. , Chuzeville G. , Clemens-Meyer F. , Jaatun M. G. , Langeveld J. , Le Gat Y. , Moin S. , Oosterom G. E. , van Riel W. , Roghani B. , Rokstad M. M. , Røstum J. , Tscheikner-Gratl F. , Ugarelli R.
Published: June 2024

It is often said that data gathering is much more expensive than data-management software (such as geographic information system). Indeed, data are perhaps the most important element of any asset management approach. In this comprehensive chapter, we embark on a journey through digital era, highlighting the pivotal role of data in our contemporary world, emphasizing the importance of data in today's landscape. We delve into the critical question of which data to collect, providing insights into the strategic selection of data based on a cost–benefit approach and the significance of anticipation in data collection. A three-layer approach, encompassing object, system, and urban fabric levels, is proposed as a structure to organize data, elucidating the diverse information requirements at each layer, from descriptive data to performance assessments and requirements. A substantial portion of this chapter is devoted to data models and bias, elucidating the complexities of modeling sewer pipe deterioration and addressing issues such as selective survival and recruitment bias. Quality control emerges as a pivotal concern, clarifying the requirements for data quality, methods to assess completeness, and handling issues such as incompleteness, timeliness, uncertainty, and imprecision. Questions related to data quantity are explored, discussing the data-loop problem, reconstruction methods, and the implications of big data. Practical considerations related to data access and storage are also addressed. The chapter concludes by three enlightening case studies illustrating real-world applications of data models.
Groundwater evolutions in the semi-arid aquifers of Dodoma City, Tanzania using stable isotopes of water and hydrogeological facies
Authors: Shemsanga Ceven
Published: June 2024

The recent influx of people into Dodoma City, Tanzania has greatly increased pressure on freshwater sources. To manage such stressed water resources, an assessment of evolutions of various groundwater masses using stable isotopes (SI) and hydrogeochemical facies was performed. The major groundwater types were found to be NaHCO3 and NaCl. The groundwater in some areas was polluted with up to 223.7 ppm of nitrate-NO3-. The majority of water masses were found to be of meteoric origin and deep aquifers were mostly replenished by heavy rains, which are more depleted in SI (δ2H and δ18O). Further, δ2H and δ18O from Hombolo Dam (HD) and Matumbulu Dam (MD) were highly enriched by evaporation, with average δ2H and δ18O values, of 5.76 & 39.69 and 2.37 & 16.34 ‰ compared to average rain values of −5.52 and −32.99‰, respectively. The contributions of highly enriched HD and MD waters to respective shallow groundwater systems were 57.52 and 22.2%. Yet, it was found that 75.4% of groundwater in the Hombolo suburb originates from the Makutupora aquifer, and this is the first time the contribution is quantified. Generally, this study offers a robust tool for adapting a local groundwater management strategy impacted by climate change, pollution, and overabstraction.
Water, sanitation, and hygiene (WASH) practices of mothers and the health status of under-five children: a study from Rural Nayagarh, Odisha
Authors: Jena Madhusmita , Panda Bhuputra , Behera Deepanjali , Mohanty Smrutirekha , Behera Manas Ranjan
Published: June 2024

The objective of this study was to assess water, sanitation, and hygiene (WASH) practices of mothers with under-five children in rural pockets of the Nayagarh district, Odisha and examine how those practices are associated with the health status of children. A cross-sectional household survey was carried out with 370 participants having under-five children in rural pockets of the Nayagarh district, Odisha. A multistage sampling strategy was adopted. Participants were interviewed using a pre-tested structured schedule. Household information was analysed using descriptive statistics; logistic regression models were used to determine the association between mothers’ handwashing practices and the health status of their under-five children. Nearly 74.9% of the households in the sample earned less than 40,000 Indian rupees ($481) annually. Nearly 73% of mothers threw the childrens' faecal waste into drains and open garbage. Diarrhoea was strongly associated with mothers who did not encourage their children to wash their hands (p = 0.007). The frequency of mothers' handwashing before feeding was associated with childrens' episodes of fever, common cold, and cough (p = 0.045). A set of targeted interventions, such as health education and socio-behavioural changes, is needed to address significant WASH factors associated with the health of under-five children in rural areas.
Integrated modeling of urban mobility, flood inundation, and sewer hydrodynamics processes to support resilience assessment of urban drainage systems
Authors: Wang Luyao , Li Ruyi , Dong Xin
Published: June 2024

With the increasing frequency of extreme weather events and a deepening understanding of disasters, resilience has received widespread attention in urban drainage systems. The studies on the resilience assessment of urban drainage systems are mostly indirect assessments that did not simulate human behavior affected by rainfall or semi-quantitative assessments that did not build simulation models, but few research characterizes the processes between people and infrastructure to assess resilience directly. Our study developed a dynamic model that integrates urban mobility, flood inundation, and sewer hydrodynamics processes. The model can simulate the impact of rainfall on people's mobility behavior and the full process including runoff generation, runoff entering pipes, node overflow, flood migration, urban mobility, and residential water usage. Then, we assessed the resilience of the urban drainage system under rainfall events from the perspectives of property loss and urban mobility. The study found that the average percentage increase in commuting time under different return periods of rainfall ranged from 6.4 to 203.9%. Calculating the annual expectation of property loss and traffic obstruction, the study found that the annual expectation loss in urban mobility is 9.1% of the annual expectation of property loss if the rainfall is near the morning commuting peak.
A novel approach for identification of environmentally and economically suitable locations for establishment of wastewater treatment plants
Authors: Singh Vivek , Samadder Sukha Ranjan
Published: June 2024

Despite having several economic and environmental benefits of locating suitable sites for wastewater treatment plants, only a few studies have been reported in the literature. The present study implemented a fuzzy-analytic hierarchy process (fuzzy-AHP) method followed by the multi-criteria decision analysis for identification of suitable locations for wastewater treatment plants. Also, the study incorporated additional parameters such as slope and relative elevation to reduce environmental hazards and to increase economic benefits of locating wastewater treatment plants. The findings of the study revealed that 2.05% (42.68 km2) of the total study area is suitable for the establishment of environmentally and economically suitable wastewater treatment plants in each zone of the study area. It was assumed that half of wastewater will be treated in the East zone and the other half will be treated in the West zone. A minimum area of 30 ha was considered to treat half of the wastewater generated and based on this, 10 suitable sites were identified with five sites located in each zone. The approach of this study will help public health engineers and other stakeholders to identify environmentally and economically suitable locations for wastewater treatment plants in the study area and other similar areas globally.
Wojciech Góralski, ‘Simulatae nuptiae nullius momenti sunt’ (D. 23, 2, 30). Symulacja zgody małżeńskiej w najnowszym orzecznictwie Roty Rzymskiej na przykładzie wybranych wyroków (2014-2021), Wydawnictwo „Bernardinum”, Pelplin 2023, ss. 208
Authors: Pietras Dawid
Published: June 2024

Recenzja publikacji
El Impacto de la Inteligencia Artificial en el Derecho del Trabajo: Evolución y Retos Futuros
Authors: Santander Gidi José Antonio
Published: June 2024

La tecnología forma parte del derecho del trabajo, precisamente, se justifica su nacimiento en un momento histórico en que comienza la industrialización de los procesos productivos y se ha ido adaptando conforme a los avances tecnológicos, pero la persona del trabajador como elemento de la relación laboral se ha mantenido desde sus orígenes. Sin embargo, llegará el momento en que el trabajo será efectuado por robots con inteligencia artificial, autónomos y capaces de decidir. Llegado ese momento, debemos resolver si estos autómatas serán considerandos como trabajadores con derechos y obligaciones.
The Magic and Mystery of TRIM65 in Diseases
Authors: Zhou Qinyi , Li Yuan , Zhou Zhixiang , Zhou Yiren , Liu Yizhou , Liu Wang , Ma Xiaofeng
Published: June 2024

Tripartite-motif protein family member 65 (TRIM65) belongs to the tripartite
motif (TRIM) protein family. Its typical structure consists of the RING, B-Box motif,
and coiled-coil domains, which are highly conserved at the N-terminus and the variable
SPRY domain at the C-terminus. TRIM65 is an E3 ubiquitin ligase that participates in
physiological and pathological processes through the ubiquitination pathway, including
intracellular signal transduction, protein degradation, cell proliferation, apoptosis, carcinogenesis,
autophagy, and phenotypic transformation. Evidence shows that TRIM65
plays a remarkable and obscure role in diseases, including multisystem tumours, neurodegenerative
diseases, immune system diseases, and inflammatory diseases. This review
is devoted to elaborating on the relationship between TRIM65 and diseases and its
pathogenic mechanism, providing a theoretical basis for TRIM65 as a possible pathogenic
target of diseases and exploring the possible future research direction of TRIM65
and the challenges it may face.
Lysyl Oxidase-like 2 Dysregulation Increases the Risk of Post-Operative Fibrotic Scars Formation in the Female Reproductive Tract: A Novel Therapeutic Target to Reduce Fibrogenesis
Authors: Khodashahi Rozita , Dehkordi Shirin , Ahmadzade Amir Mahmoud , Ferns Gordon A , Aliakbarian Mohsen , Arjmand Mohammad-Hassan
Published: June 2024

The formation of fibrotic bands in the female reproductive system, including
the uterus, after abdominal and pelvic surgeries, is an important medical challenge associated
with many complications, including infertility and pain. Investigating the role of
different molecules involved in fibrosis and adhesion formation may help in the development
of new drugs to prevent this disorder. Lysyl oxidase-like 2 (LoxL2) is a copper-dependent
enzyme that catalyzes the cross-linking of collagen and elastin fibers in the extracellular
matrix (ECM) to stabilize ECM. Dysregulation of LoxL2 activity resulting
from tissue hypoxia and inflammation after gynecological surgeries in the female reproductive
tract increases collagen fibers cross-linking and promotes fibrosis. It has been
shown that targeting LoxL2 by Lox inhibitors may reduce fibrosis. Considering the expression
of LoxL2 in female reproductive organs and its dysregulation in hypoxia and inflammation,
LoxL2 may have therapeutic potential as a drug target in the prevention of
adhesions. In this review, we discuss the role of LoxL2 in the promotion of fibrotic processes,
focusing on its link with inflammatory and hypoxic conditions. We also justify
the use of anti-LoxL2 agents as a potential therapeutic strategy for the prevention of
post-surgical scar formation.
Insights into the Biomedical and Pharmaceutical Potential of Deleserriaceae: A Comprehensive Review
Authors: Malhotra Rohit , Cojandaraj Louis
Published: June 2024

The family Delesseriaceae possesses enormous bioactive medicinal and pharmacological
constituents that have calculable positive effects on various diseases in humans. The Delesseriaceae
family contains approximately 25 different marine species that are found throughout coastal areas.
This review aims to integrate global scientific literature, including seaweed studies in Mandapam, to
provide a comprehensive understanding of Deleserriaceae species, encompassing taxonomy, ecology,
and potential applications. Nitophyllum species contain bioactive components, especially polysaccharides
and proteins. Deleseriaceae, a seaweed recognized for its nutritional richness, presents a
potential resource for various therapeutic applications. However, it's important to note that the specific
activities mentioned, such as insulin sensitization, lipid peroxidation inhibition, antimicrobial
effects, and antioxidant properties, might not be well-documented or established in Deleserriaceae
species such as Nitophyllum marginale, Nitophyllum punctatum, Nitophyllum hommersandii venvorstia
spectabilis, Martensia indica, Taenioma perpusilium, and Martensia fragilis. Further research
is required to ascertain the exact bioactive compounds and potential health benefits associated with
this seaweed species.
Comprehensive Review on Alzheimer’s Disease: Natural Therapeutics, Gaps and Challenges
Authors: Mishra Prem Shankar , Mishra Rakhi , Kumar Anuj
Published: June 2024

More than 20 million people worldwide have Alzheimer's disease (AD), making it the
most prevalent disease. Patients with AD may live for at least a decade after diagnosis, making it
the most common cause of disability in the elderly. Each year, 1% to 4% of the population is affected
by AD, with prevalence peaking between ages 65 and 70 and declining to 6% among those
over 85. Researchers have accumulated evidence on medicinal herbs that may reverse the pathogenesis
of Alzheimer's disease. Alzheimer's disease (AD) is associated with severe memory loss,
which can negatively impact social and professional life. The first neurotransmitter linked to Alzheimer's
was acetylcholine (ACh). There is no known cure, and the available treatments are ineffective.
Multiple studies indicate that Ayurvedic restorative herbs and their constituents may be effective
in treating Alzheimer's disease. This technique emphasizes the fact that delaying or preventing
Alzheimer's disease with the help of natural bio-actives could reduce the number of cases over
the next half-century. To provide detailed information, the pathology and pathophysiology of Alzheimer's
Disease are discussed in the text of this review, along with an overview of the neurotransmitters
involved in the progression of the disease. The importance of different natural bioactives
for the treatment of Alzheimer's disease is also outlined in the paper. The information contained
in this paper can serve as a template for future research expressing the more beneficial role
of other bioactive in acting as an adjuvant in the prevention and treatment of this disease, facing
certain challenges and gaps with conventional drugs used to treat Alzheimer's disease.
Enhancing Medical Image Security through a Novel Framework: Crypto-aware Elliptic Curve Diffie-hellman with Key Derivation Function
Authors: Senthilkumar M. , Suthendran K. , Ravi Vinayakumar
Published: June 2024

Aim

To develop and apply advanced methods to enhance medical image security, ensuring patient data integrity, confidentiality, and authenticity throughout the stages of image collection, transmission, and storage.

Background

Retaining patient privacy and data accuracy in the context of accessible healthcare require the secure broadcast and storage space of medical imaging. Because of the increasing dependence on digital medical imaging technology, it is essential to protect these private images from illegal access and possible cyber attacks.

Objective

Work addresses the drawbacks of conventional encryption techniques in the healthcare sector and offers a novel Crypto-Aware Elliptic Curve Diffie Hellman with Key Derivation Function (CAECDH-KDF) encryption technique to improve the security of medical images.

Methods

The suggested encryption architecture combine domain-specific methods designed for medical imaging data with sophisticated cryptographic algorithms. The framework, in difference to conservative encryption methods, employs an effective tactic that strikes a compromise between processing speed and security. To achieve this, better encryption methods for medical image characteristics are incorporated.

Results

Comparisons are made between the suggested method's security, computation time (0.003001), encryption time (0.001998s), decryption time (0.001001s), entropy (7.997633), and throughput (4.0887) of conventionally encrypted approaches.

Conclusion

A large amount of test images have been utilized to evaluate the effectiveness of the suggested technique. According to numerous tests, the suggested strategy outperforms conventional methods.
Plasma Protein Adsorption on Melphalan Prodrug Bearing Liposomes - Bare, Stealth, and Targeted
Authors: Kobanenko Maria , Samofalov Pavel , Kapitonova Irina , Alekseeva Anna , Kapkaeva Marina , Scheglovitova Olga , Tuzikov Alexander , Tretiakova Daria , Vodovozova Elena
Published: June 2024

Background:

Plasma protein binding is inevitable for nanomaterials injected into blood circulation. For liposomes, this process is affected by the lipid composition of the bilayer. Membrane constituents and their ratio define liposome characteristics, namely, surface charge and hydrophobicity, which drive protein adsorption. Roughly 30 years ago, the correlation between the amount of bound proteins and the resulting circulation time of liposomes was established by S. Semple, A. Chonn, and P. Cullis. Here, we have estimated ex vivo plasma protein binding, primarily to determine the impact of melphalan prodrug inclusion into bilayer on bare, PEGylated (stealth), and Sialyl Lewis X (SiaLeX)-decorated liposomes.

Experimental:

Liposomes were allowed to bind plasma proteins for 15 minutes, then liposome-protein complexes were isolated, and protein and lipid quantities were assessed in the complexes. In addition, the uptake by activated HUVEC cells was evaluated for SiaLeX-decorated liposomes.

Results::

Melphalan moieties on the bilayer surface enrich protein adsorption compared to pure phosphatidylcholine sample. Although PEG-lipid had facilitated a significant decrease in protein adsorption in the control sample, when prodrug was added to the composition, the degree of pro-tein binding was restored to the level of melphalan liposomes without a stealth barrier. A similar effect was observed for SiaLeX-decorated liposomes.

Conclusion:

None of the compositions reported here should suffer from quick elimination from circulation, according to the cut-off values introduced by Cullis and colleagues. Nevertheless, the amount of bound proteins is sufficient to affect biodistribution, namely, to impair receptor recog-nition of SiaLeX and reduce liposome uptake by endothelial cells.
Neuroinflammatory Mechanism of Neuropathic Pain in Breast Cancer and Diabetes
Authors: Sensharma Sreemoyee , Thakuria Nilakshi , Pramanik Subrata
Published: June 2024

The understanding of the complex relationship between the immune and
nervous systems has significantly evolved in recent years. It is now recognized that the
inflammatory response and interactions between these two systems play crucial roles in
the development and progression of neurodegenerative diseases and injuries. The
immune and nervous systems are intricately connected, with bidirectional
communication pathways that allow them to influence each other's functions. This
cross-talk is mediated by various signaling molecules including cytokines, chemokines,
and neurotransmitters. Neuropathic pain is a debilitating condition that arises as a result
of damage or dysfunction in the central nervous system (CNS) or peripheral nervous
system (PNS). Neuropathic pain is a common pathological symptom of cancer and
diabetes. Neuropathic pain can be generated by resulting injury to peripheral or central
neurons through various neural pathways, ion channels, receptors, and
neurotransmitters. In this article, we elaborate on the recent progress in the
understanding of mechanism of the neuroinflammation. First, we provide current
knowledge of neuroinflammatory molecules and their association with
neuroinflammation. Subsequently, we describe recent advances in the understanding of
the pathophysiology of neuropathic pain in PNS and CNS, emphasizing breast cancer
and diabetes. Finally, we highlighted the current challenges of molecular understanding
and diagnosis regarding targeted therapies for the treatment of neuropathic pain.
Insulin and Hypoxia in Breast Cancer Cell Invasion and Migration
Authors: Chakraborty Ratul , Das Debanjana , Goswami Ayan , Rajabalaya Rajan , David Sheba R. , Balaraman Ashok Kumar , Hemalatha S. , Bala Asis
Published: June 2024

Uncontrolled cell division resulting in cancer is a significant contributor to
mortality rates, with breast cancer being the most common form affecting women.
When the disease progresses, the uncontrolled cell division can spread through the
bloodstream to other parts of the body, making treatment through chemotherapy and
radiation therapy challenging. As such, there is an urgent need for the discovery of new
drugs and targets to combat this disease. This chapter delves into the physiological role
of insulin and hypoxia in breast cancer cell invasion and metastasis, which can
potentially increase the druggability of the pathway. It is a valuable resource for those
researching new druggable targets in these pathways.
Diabetes, Obesity, and the Risk of Breast Cancer: An Attempt to Decipher the Interconnections
Authors: Barbhuiya Pervej Alom , Warjri Ireenia , Das Priyam Jyoti , Ahmed Shiny , Pathak Kalyani , Laskar Abdul Mannaf , Pathak Manash Pratim
Published: June 2024

Diabetes and obesity are linked to a higher risk of breast and other cancers.
In addition to the direct effects of hyperglycaemia and insulin resistance on breast
cancer cells, the complications of diabetes, obesity, and metabolic syndrome are
characterised by a dysfunctional endothelium and increased inflammation in tissue
phenomena that are intimately related and occur concurrently in breast cancer
progression. However, the complexity of the underlying mechanisms, together with the
interplay of diet and physical activity contributing to energy balance and the role of
adipose tissue, hyperglycaemia, insulin resistance, and glucose intolerance, pose
challenges to our understanding of the basis of this increased risk. In addition to being
an established risk factor for postmenopausal breast cancer, abdominal obesity, also
known as central obesity, may also raise the chance of triple-negative breast cancer,
which is more common in premenopausal women. This chapter explains how various
parameters like oestrogen, mammography, density, adipokines, insulin-signalling
pathway activation, and inflammatory conditions, may play a part in this seemingly
contradictory association. A key focus of this chapter is to better understand the impact
of obesity and diabetes in the pathogenesis of breast cancer and, hence, provide some
clarity into the interrelationships involved in between.
A familia sometida a un exercicio de enxeñería conceptual
Authors: Permuy Aixa , Latorre Ruíz Enrique
Published: June 2024

Contra-relatar a idea de familia, ou incluso falar de abolila, semella un imperativo a recuperar fronte a todas esas violencias que acompañan as loitas polas liberdades das disidencias sexuais e de xénero. Ademais de polas demandas, pasadas e presentes, de outras formas de estar no mundo e relacionarse, á marxe dos itinerarios vitais cisheterosexuais monógamos; aínda que nada haxa máis importante que a familia.
Sábese que hai algo que asusta cando se fala de abolición, tal  como reflexiona Lewis (2023); porque isto obriga a un desafío senti-mental bastante aterrador: “pero, se eu quero á miña familia!”.
O presente traballo pretende, a través dun exercicio de enxeñería conceptual, analizar a familia, recordando que os significantes non son esenciais, senón simples obxectos de acción, ferramentas que producimos para afrontar a realidade e, por tanto, elementos susceptibles de avaliación e, segundo o caso, de reparación.
Nun momento no que o concepto de familia parece non funcionar, propoñemos unha reflexión favorable á postura abolicionista, sobre os seus límites e naufraxios, acompañada dunha proposta de intervención socioeducativa, enmarcada nunha pedagoxía queer dos afectos, resultado de repensar ese lugar ao que pertencer, onde sentirse a salvo e fabricar mundo.
Effect of gamma radiation on the content of free proline and malonic aldehyde in barley seedlings
Authors:   Obninsk Institute for Nuclear Power Engineering, Afonina S.O. , Komarova L.N. ,   Obninsk Institute for Nuclear Power Engineering, Rasskazova M.M. ,   Obninsk Institute for Nuclear Power Engineering, Atamanovskaya G.A. ,   Obninsk Institute for Nuclear Power Engineering, Pavlov A.N. ,   Russian Institute of Radiology and Agroecology of National Research Centre «Kurchatov Institute»
Published: June 2024

It is well known that the formation of reactive oxygen species in the organism due to the impact of negative factors of various nature is one of the main mechanisms of stress state formation at the level of cells and tissues. In plants reactive oxygen species play a key role in the response to abiotic stress through signalling and activation of the defence system. The purpose of the work is to study the effect of gamma radiation on the content of malondialdehyde (MDA) and free proline in seedlings of common barley (Hordeum vulgare L.) of three varieties. The effect of radiation was assessed by changes in the concentrations of the substances under study, which was determined by the photometric method. It was shown that a statistically significant increase in the MDA content in germinated seeds of the Vityaz and Ladny varieties was observed when irradiated at doses of 2, 5, 10, 25 and 50 Gy, and in the Badjoriy variety when irradiated at doses of 2, 20, 25 and 50 Gy. An increase in the concentration of free proline was observed at all studied doses of gamma irradiation, with the exception of irradiation at a dose of 15 Gy for the Vityaz and Ladny varieties. A relationship was noted between the content of free proline and MDA in plant material (correlation coefficient for the Vityaz variety – 0.871+/-0.121; for the Ladny variety – 0.892+/-0.103; for the Badjoriy variety – 0.886+/-0.112). Regardless of the variety, the observed changes in the studied parameters demonstrate similar dynamics, which is of practical value for assessing the degree of technogenic pollution of agricultural biogeocenoses. The obtained quantitative data will make it possible to determine the optimal radiation doses for each zoned variety, which will help optimize the use of radiation technologies in agriculture.
Negocios verdes y prácticas sostenibles en zonas de amortiguamiento: guía para agricultores y ganaderos
Authors: Ramos Zambrano Housseman Steven , Luna Mancilla Lizeth Tatiana , Rodríguez Puertas David , Meneses Buitrago Diego Hernán , Ortega Cepeda María Camila , López Rendón Juan Fernando
Published: June 2024

Las zonas de amortiguamiento en ecosistemas de páramo juegan un papel crucial como corredores biológicos y reguladores ambientales. Estas áreas brindan oportunidades para establecer negocios verdes y actividades productivas sostenibles que generen ingresos sin comprometer la biodiversidad. Ejemplos de estos emprendimientos incluyen cultivos agroecológicos, sistemas de ganadería silvopastoriles, apicultura, turismo rural y arqueológico, y elaboración de artesanías. Al adoptar técnicas como la rotación de cultivos, el compostaje y el manejo integrado de plagas, se reduce el uso de agroquímicos y se conserva la fertilidad del suelo. Estos negocios verdes ofrecen múltiples beneficios: generan empleo local, preservan servicios ecosistémicos como la regulación hídrica, contribuyen en la captura de carbono y fomentan la soberanía alimentaria. Sin embargo, enfrentan retos como la falta de incentivos, el acceso limitado a mercados y la necesidad de capacitación técnica. Con planificación adecuada y el compromiso de comunidades, autoridades y empresas, las zonas de amortiguamiento pueden convertirse en modelos de desarrollo sostenible, combinando conservación ambiental con oportunidades económicas responsables para las poblaciones locales.
eHealth use and psychological health improvement among older adults: The sequential mediating roles of social support and self-esteem (Preprint)
Authors: Ao Song Harris , Zhu YIngxia , Wu Yifang , Zhao Xinshu
Published: June 2024

BACKGROUND

As the trend of population aging increases in many countries around the world, the mental health of the elderly has become an increasing concern. Psychological health is widely recognized as a crucial factor in enhancing older adults' quality of life. Concurrently, Internet use among older adults has risen in recent years, and the impact of these technologies may have a significant influence on the psychological health of older adults.

OBJECTIVE

China is one of the countries with a typical aging trend. The current study aims to reveal the mechanism of how eHealth use influences older adults’ psychological health in China. Furthermore, this study aims to examine the roles of social support and self-esteem in the relationship between eHealth use and psychological health based on the Stimulus-Organism-Response (SOR) framework and Social Cognitive Theory (SCT).

METHODS

The empirical data for this study were drawn from all 31 provinces of China. The study targeted adults aged 18 and above who resided in China. Mediation and moderation analyses were conducted to test the hypotheses proposed in this study. From the total sample of 7,019 participants, 898 older adults aged 60 and above were selected for the analysis.

RESULTS

The findings reveal that eHealth use is positively associated with psychological health through the serial mediation of social support and self-esteem. Additionally, the study also identified eHealth can increase both perceived family and friends support among older adults, and both family and friends support can increase older adults’ self-esteem.

CONCLUSIONS

To promote better psychological health among older adults, it is essential for them to access eHealth tools. eHealth use can improve older adults’ psychological health by increasing their perceived family and friends’ support, which can then facilitate their self-esteem and eventually enhance their psychological health.