bluuebunny/crossref_metadata_2025 huggingface dataset:
A multifunctional T-cell engager containing CD80 enhances prostate cancer treatment
Authors: Nie Disen , Jiang Yao , Li Hui , Zhang Keying , Li Zhengxuan , Lu Tong , Li Yu , Han Donghui , Shi Changhong , Xing Nianzeng , Yang Fa , Wen Weihong , Qin Weijun
Published: November 2024

Background: T-cell engagers (TCEs) are the most examined bispecific antibodies that recognize and target effector T cells to generate immune synapses against tumor cells, thereby resulting in T-cell activation and tumor killing. However, the inhibitory influence of the tumor microenvironment on TCEs' functionality has impeded their utilization in solid tumor therapies. To circumvent this limitation, we enhanced bispecific prostate-specific membrane antigen (PSMA)/CD3 TCEs by incorporating the extracellular segment of CD80 to overcome T-cell inhibition in prostate cancer by delivering a second activation signal to T cells, designating this trifunctional antibody as TriTE-N13.
Methods：Using gene editing and eukaryotic expression techniques, we developed the fully humanized fusion antibody TriTE-N13. In vitro, we assessed its effects on T-cell activation, proliferation, and cytotoxicity, and tested the T-cell targeting cytotoxicity function of TriTE-N13 against PSMA+ tumor cells in both cell co-culture models and tumor cell spheroid models. Furthermore, in humanized immune-reconstituted mouse models, we evaluated the in vivo efficacy and safety of TriTE-N13 against prostate cancer xenografts.
Results: In vitro, TriTE-N13 can notably activate human T cells and exhibits excellent binding activity to human PSMA and CD3 antigens. Meanwhile, TriTE-N13 can mediate T-cell-induced cytotoxicity against PSMA-positive prostate cancer cells. In vivo, we demonstrated that TriTE-N13 significantly reduced tumor volume compared to bispecific TCEs when treating initially large-sized tumors.
Conclusions: Our data suggest that the incorporation of CD80 as a second pathway activator significantly enhances the solid tumor-killing effect of TCEs, thereby positioning TriTE-N13 as a promising immunotherapy candidate for the treatment of advanced prostate cancer.
Industrial Mobile Robot Navigation Based on the LiDAR-IMU-Visual Measurements
Authors: Song Min , Zhang Yinlong
Published: November 2024

Simultaneous localization and mapping (SLAM) has emerged as a pivotal technology for enabling precise navigation and autonomy in industrial robotics. Despite its significance, SLAM systems often contend with cumulative errors over time and the lack of a fixed reference for absolute positioning, which can limit their effectiveness in complex industrial environments. This research addresses these challenges by leveraging the complementary strengths of Lidar-Inertial Measurement Unit (IMU) systems and downward-facing visual sensors for the purpose of guiding industrial robots. The data from these sensors are fused within a factor graph framework, which is a robust mathematical structure for modeling and solving SLAM problems. A novel aspect of our approach is the integration of downward visual data, specifically through the use of QR codes as factors within the graph, to achieve accurate robot positioning.Moreover, we have developed an enhanced Iterative Closest Point (ICP) algorithm tailored for refining the orientation of the robot. This refined ICP algorithm improves the alignment of Lidar scans, thereby reducing errors in the estimation of the robot’s pose. To augment the precision of the mapping process, an extended Kalman filter is implemented to mitigate Lidar measurement noise and to refine the accuracy of the maps generated by the Lidar system. This filter serves as a cornerstone for robust state estimation, ensuring that the robot maintains a high degree of localization accuracy even in the presence of environmental disturbances.The proposed SLAM system has been thoroughly evaluated on a custom-designed industrial robot platform, demonstrating its efficacy in real-world scenarios. The integration of Lidar, IMU, and visual data within the factor graph framework, along with the enhanced ICP and extended Kalman filter, has resulted in a more reliable and accurate SLAM solution for industrial robotics. Our findings suggest that this multi-sensor approach can significantly improve the performance of industrial robots in terms of navigation, mapping, and overall operational efficiency, making it a promising advancement for the automation industry.
Synthesis and diagnosis of chemical dye capable of staining some fish histological sections
Authors: Al-Waeli jassim , Abdull-majed Hasanain A. , Ibrahim Munera A. , Ismael Sadiq M-H.
Published: November 2024

The synthesis of dyes is crucial for the study of animal and plant tissue. We developed a method based on the creation of a new pigment and compared it with other commonly used pigments to stain histological sections of bone. The dye has been synthesized by reacting the amino part with the phenolic part of the chemical compound (2-aminophenol) at a ratio of 1:1 and by diazotization and coupling. The diagnosis was made using techniques 1HNMR, FT-IR, mass spectrum, melting point, and other analytical techniques that confirmed the formation of the dye. The dye solution was perfected in bone histological sections for some types of fish. The dye was assessed by analyzing a picture of three types of bone histological sections of the fish and comparing them with alizarin red. Alizarin red smudging techniques have been compared to determine the reliability of these methods. We found that the staining of the dye gave great differences between bone tissue and other tissue components. The performance of the created dye can be more useful than that of other pigmentation methods for several reasons. The synthesis is easy, the pigment is stable, and the pigment solution does not collapse after preparation and remains for a long time. In addition, the accuracy, clarity and contrast of the contents of the bone histological section were assessed.
The Impact of [Meta] Talk about Writing on Metalinguistic Understanding and Written Outcomes: A Review
Authors: Newman Ruth
Published: November 2024

Classroom talk about language use may support young writers’ capacity to enact choice and control over their written production and is thus a key pedagogical tool in writing instruction (Myhill & Newman, 2016, 2019). However, relatively little is known about the nature of learning transfer in writing instruction, particularly how what is spoken in the classroom influences learners’ written outcomes. This paper, therefore, examines the L1 (first language) and L2 (second and additional language) literature for evidence of how talk about writing influences learners’ metalinguistic understandings (knowledge about language use) and writing choices. It also draws out from the literature approaches that promote the kinds of talk conceived of as impactful in the development of these understandings about and for writing. The findings might usefully inform pedagogical and methodological approaches to instructional interventions that seek to both establish and advance the impact of talk about writing.
Transformation of information hygiene tools
In the context of the Russian-Ukrainian war
Authors: Melnykova-Kurhanova Olena , Kozharina Valeriia
Published: November 2024

Introduction. Information hygiene has become critically important in the context of the Russian-Ukrainian war. The rapid development of information technology and methods of information warfare has necessitated the adaptation of strategies to protect against disinformation and manipulative content.
Relevance and purpose. The relevance of the study lies in the need to understand and improve methods of protection against information threats in the context of the ongoing war. Given the intensity of cyberattacks and the use of the latest technologies to create and spread disinformation, the study of the transformation of information hygiene is important. The protection of personal data, continuous improvement of media literacy, and the ability to choose quality media are important issues for the Ukrainian audience. The purpose of the study is to identify changes in the information hygiene tools in Ukraine since the beginning of the full-scale invasion, as well as the specifics of a set of measures to counter disinformation and destructive narratives in the context of the Russian-Ukrainian war. Particular attention is paid to the study of adaptive mechanisms for countering disinformation and destructive narratives in the context of the Russian-Ukrainian war. This study aims to identify new strategies and tools that can effectively protect the country’s information space in the face of intense confrontation.
Research methods. The research was based on the analysis of scientific literature, comparison of media literacy data, case studies of media education initiatives, and expert evaluation.
Results. The article analyses the evolution of online media literacy courses that have adapted to the new challenges of the information war. New methods of fact-checking and countering disinformation created by AI are considered. The concept of infodetection as a method of adapting information hygiene is explored.
Conclusions. Information hygiene in Ukraine has undergone a significant transformation, adapting to the challenges of war. Raising the level of media literacy, developing specialised educational programmes and improving fact-checking methods contribute to building the society’s resilience to information threats. An important aspect is the constant change in information hygiene methods to meet new technological challenges, including the use of AI in creating disinformation.
Forensic veterinary evaluation of injuries caused by a shot with a smoothbore weapon in domestic dogs
Authors: PANASIUK-FLAK KINGA , LISTOS PIOTR , BUSZEWICZ GRZEGORZ , CHAGOWSKI WOJCIECH , TERESIŃSKI GRZEGORZ
Published: November 2024

Gunshot injuries in animals are an important subject of forensic veterinary expert opinions. The common occurrence of shootings with hunting weapons in veterinary and forensic practice and the need to determine their cause and effects and to identify the ammunition used, make it necessary to investigate characteristic features of injuries caused by various types of ammunition. This experiment involved shooting research material, i.e. nine carcasses of domestic dogs, with various calibres from distances of 0 m (contact shot), 1.2 m and 10 m. Pellets with diameters of 2.4 mm or 8.45 mm and slugs were used to obtain the full spectrum of injuries that may result from a shot with a smoothbore weapon. Next, colour tests were performed to identify gunshot residues in the area of the wound, as well as imaging tests, i.e. X-ray and CT, necropsy and a histopathological examination of tissues around the entry wound. The results reveal the possibility of extensive injuries to the tissues and bones of victims of gunshot wounds. A thorough analysis of the results of the experiment with projectiles of various calibres indicates that the extent and location of the damage are correlated with the calibre, diameter and bodymass of the pellets, their initial velocity and the distance between the end of the barrel and the object shot.
Pig welfare in the agenda of the 27th IPVS World Congress and the 15th. ESPHM symposium in Leipzig
Authors: KOŁACZ ROMAN , NOWAK MACIEJ
Published: November 2024

This study aimed to assess the occurrence of M. bovis antibodies and their risk factors in cattle in Poland. Serum samples were collected from 154 cattle from 13 Voivodeships during routine veterinary procedures from February to March 2024. The animals’ ages ranged from 6 months to 13 years. M. bovis antibodies were detected in serum samples by Monoscreen Ab ELISA Mycoplasma bovis kits (Bio-X Diagnostics S.A., Belgium). The obtained results were subjected to statistical analysis using Sterne’s exact method and logistic regression model. Antibodies against M. bovis were detected in sera from 40/154 animals. None of the analysed factors influenced seroprevalence. Our study revealed 26% M. bovis seroprevalence in cattle from different regions of Poland. Based on previous research performed in Europe, the results of this study can be classified as medium seroprevalence. Due to the lack of effective vaccines against M. bovis, increasing antimicrobial resistance of field isolates, M. bovis infections and seroprevalence in Polish cattle should continue to be monitored.
Morphometric parameters of canine spermatozoa: Comparison between conventional microscopy and CASA system
Authors: BELALA RÉDHA , KEBBAL SEDDIK , BOUGUETOF CHAOUKI , MEDJKOUNE MYRA , MECHEROUK CHOAYB , MIMOUNE NORA
Published: November 2024

The present study aimed to evaluate the effect of two cell detection parameters (Head Brightness Minimum „HBM” and head surface „AREA”) on the automatic morphometric analysis of canine spermatozoa (spz) by using Hamilton-Thorne (HT)-IVOS II CASA system. Twenty ejaculates were collected from 6 identified dogs and the spz morphology was analyzed by conventional technique (microscopy) and by the HT-IVOS II system in two different situations (mobile and static spz). The 20 videos recorded from the preliminary analysis of the ejaculates were reassessed by modifying the two parameters of the setup studied according to an optimization protocol which made it possible to obtain 1120 IVOS II analyses. Statistical analysis was performed using IBM-SPSS software. Data showed a very significant effect of HBM on normozoospermia and teratozoospermia rates. On the contrary, the AREA factor did not affect spz quality except for the extreme values (14-16 μm²). Indeed, the HBM of 140 and the AREA between 4-10 μm² seemed to be the most suitable cell detection setting for automatic morphometry by the HT-IVOS II system and it can constitute an alternative to microscopy. In addition, Improper parameterization of the HBM could induce contrast artifacts leading to an overestimation of the major anomaly “Proximal Droplet”. SPZ immobilizing before analysis by the HT-IVOS II system did not improve the results. To conclude, the authors suggest that manufacturers of CASA systems should ensure complete validation of the settings loaded on their systems in order to prevent random adjustments by users leading to great intra- and inter-laboratory variability in the results of automatic morphometry.
Necessidades e comportamentos informacionais de profissionais de enfermagem no tratamento de feridas
Authors: Silva Bruno Santana da
Published: November 2024

Profissionais de Enfermagem usam sistemas de informação durante suas atividades. Para avaliar se esses sistemas de informação são adequados e bons, antes é preciso conhecer as necessidades e comportamentos informacionais dos seus usuários. Trabalhos anteriores investigaram as necessidades e comportamentos informacionais de profissionais de Enfermagem, mas poucos deles foram com profissionais que atuam no Brasil e geralmente focam o conhecimento técnico-científico destes profissionais. Este trabalho teve por objetivo investigar necessidades e comportamentos informacionais de profissionais de Enfermagem durante o tratamento de feridas na pele. Realizou-se uma pesquisa quantitativa descritiva através de um questionário online respondido por 566 participantes de quase todos os estados brasileiros. Os participantes manifestaram a necessidade de analisar informações específicas da ferida e também sobre a saúde do paciente como um todo. As principais fontes de informação são o próprio paciente, o prontuário em papel, outros colegas e softwares. As informações produzidas durante os atendimentos aos pacientes são registradas em fotos, em papel, no computador, no smartphone e em gravações de áudio. Essa compreensão sobre as necessidades e comportamentos informacionais devem ser consideradas no desenvolvimento e melhoria de sistemas de informação que apoiam o trabalho de profissionais de Enfermagem durante o tratamento de feridas.
Pesquisa participativa na avaliação de armadilhas e contole populacional de cosmopolites sordidus
Authors:   , Santos Saint Clair Lira
Published: November 2024

A banana (Musa spp) é uma das frutas mais consumidas no mundo. Constituise num importante alimento, em razão de sua composição química e conteúdo em vitaminas e minerais, principalmente potássio. Destaca-se por ser versátil, pelo seu sabor, baixo preço e facilidade de consumo in natura, favorecendo a população de menor poder aquisitivo economicamente. São vários os desafios que se colocam à produção de banana no mundo, dentre eles o aspecto da segurança alimentar, no que concerne não só à quantidade produzida, mas também à qualidade dos frutos, principalmente sob o aspecto da exigência de produtos livres de agrotóxicos. Focado sob a ótica da temática agroecológica, este estudo considerou a participação dos agricultores locais, como agricultores experimentadores oportunizando em sua área de trabalho, não só um ambiente de pesquisa, mas também uma unidade de demonstração para estudantes e produtores(as) de banana da região. Esta pesquisa teve como principal objetivo, estudar a dinâmica populacional de C. sordidus e avaliar armadilhas ao seu controle nas condições do Vale do Açu-RN. Objetivou-se também, colaborar com o suporte técnico aos produtores locais, já que a pesquisa proporcionou o envolvimento desses, durante e pós os experimentos, como forma de se lograr uma apropriação participativa dos resultados. Verificou-se dinâmica populacional dos adultos de C. sordidus, de modo que o pico populacional foi no mês de junho de 2010. Quanto às larvas, verificou-se que ocorreram dois picos populacionais, no mês de dezembro de 2009 e no mês de julho de 2010. As variáveis climáticas não influenciaram na dinâmica populacional de adultos e produziram efeitos negativos na população jovem desses insetos, sobretudo a precipitação pluvial e umidade relativa do ar. Houve diferença entre as armadilhas estudadas quanto à eficiência de captura do C. sordidus. Considerando-se 4 coletas, economicamente, o melhor tratamento foi o T4 , Isca tipo telha (80 iscas/ha), que apresentou a menor relação entre custo total e média de insetos capturados. Considerando-se 8 coletas, economicamente o melhor tratamento foi o T1 , Cosmolure® Tambor, que apresentou a menor relação entre Custo Total e Média de insetos capturados. O tratamento com isca tipo telha (T4) representa maior sustentabilidade para a agricultura familiar, por não criar a dependência externa de insumos e por outro lado, propiciar ocupação da mão-de-obra, contribuindo para a geração de renda e preservação ambiental
Antiterrorismo y contraterrorismo en América Latina: Argentina, Brasil y México ante el terrorismo islámico global (2001-2019)
Authors: Hodge-Dupré Eduardo
Published: November 2024

Este libro analiza el antiterrorismo y contraterrorismo en Argentina, Brasil y México frente a la amenaza del terrorismo islámico global desde el 11 de septiembre de 2001 hasta 2019. Partiendo del impacto del ataque a Estados Unidos se explora cómo este tipo de terrorismo, sin fronteras y con fundamentos religiosos y antioccidentales, ha influido en la seguridad global. América Latina, aunque menos afectada directamente, presenta condiciones que podrían atraer ataques futuros, como su proximidad geográfica a Estados Unidos, ser una población predominantemente cristiana y la presencia de comunidades judías significativas en Argentina y Brasil. El análisis profundiza en las leyes y políticas de cada país y examina sus capacidades en inteligencia, ciberseguridad y control de armas, reflejando deficiencias frente a amenazas internacionales. Además, se estudian las fuerzas de seguridad y contraterrorismo, sus entrenamientos y la articulación entre estos países para enfrentar posibles ataques. La investigación concluye que, aunque no se han manifestado grandes atentados islámicos en la región, Argentina, Brasil y México deben ajustar sus políticas y leyes para responder a estos desafíos en el marco de la seguridad internacional y el contexto global de violencia islámica.
Enhancing artistic expression through installation art: A training program based on the experimental dialectical approach
Authors:   Faculty of Education, King Faisal University, Al-Ahsa, Saudi Arabia, Shahat Hussein Ahmed , Al-Naim Noura Samir Hamad ,   Faculty of Education, King Faisal University, Al-Ahsa, Saudi Arabia
Published: November 2024

This study aims to assess the effectiveness of an experimental dialectical approach in improving artistic expression skills and to examine the relationship between using synthetic art and the development of these skills with materials and media. To do this, a quasi-experimental method was used. The study involved 80 female second-year middle school students from Al-Ahsa Governorate, divided into two groups: an experimental group and a control group, each with 40 students. A scale measuring artistic expression skills was used to evaluate their performance. Researchers were trained through a specific program. The results showed significant differences between the experimental group and the control group in the use of materials and media, with the experimental group performing better in the post-test. Additionally, there was a positive correlation between the use of installation art and the development of artistic expression skills related to materials and media in the experimental group after the intervention. Based on these findings, further studies on fine arts and their impact on developing artistic expression skills in students at different educational levels are recommended.
Effectiveness of the Support From Community Health Workers and Health Care Professionals on the Sustained Use of Wearable Monitoring Devices Among Community-Dwelling Older Adults: Feasibility Randomized Controlled Trial
Authors: Wong Arkers Kwan Ching , Bayuo Jonathan , Su Jing Jing , Wong Frances Kam Yuet , Chow Karen Kit Sum , Wong Bonnie Po , Wong Siu Man , Hui Vivian
Published: November 2024

Background

The wearable monitoring device (WMD) is emerging as a promising tool for community-dwelling older adults to monitor personal health, enhance awareness of their activities, and promote healthy behaviors. However, the sustained use of WMDs among this population remains a significant challenge.

Objective

This study aims to implement an interventional program that promotes and motivates the continued use of WMDs among older adults through a peer and professional support approach. This program will facilitate the integration of WMDs into their daily lives.

Methods

This feasibility trial examined the following: (1) the usability of the WMD from the users’ perspectives; (2) the feasibility of the Live With Wearable Monitoring Device program; and (3) the effectiveness of the Live With Wearable Monitoring Device program among community-dwelling older adults. The intervention, based on Self-Determination Theory, involved using the Live With Wearable Monitoring Device program over a 3-month period, with ongoing professional and peer support provided by community health workers, aided by a nurse and social workers. This support included 1 home visit and biweekly communication via WhatsApp. Data were collected at baseline and at 1, 3, and 6 months.

Results

A total of 39 participants were enrolled in the intervention group, while 37 participants were in the control group. The recruitment rate was high (76/89, 85%), and the attrition rate was low (8/76, 11%), indicating that the program is feasible for older adults. Participants in the intervention group exhibited higher self-efficacy, lower anxiety levels, and used the smartwatch more frequently, in terms of both days and hours, compared with the control group. A between-group difference was observed in self-efficacy between the intervention and control groups (β=3.31, 95% CI 0.36-6.25, P=.03), with statistically significant higher mean values recorded at all 4 time points.

Conclusions

It is clear that merely providing a WMD to older adults does not guarantee its usage, particularly for those unfamiliar with how to utilize its health-related functions in their daily routines. This study implemented a theory-based program aimed at enhancing the ongoing use of WMDs among older adults, suggesting that continuous professional and peer support may significantly influence WMD usage.

Trial Registration

ClinicalTrials.gov NCT05269303; https://clinicaltrials.gov/ct2/show/NCT05269303
Investigating the Classification of Living Kidney Donation Experiences on Reddit and Understanding the Sensitivity of ChatGPT to Prompt Engineering: Content Analysis
Authors: Nielsen Joshua , Chen Xiaoyu , Davis LaShara , Waterman Amy , Gentili Monica
Published: November 2024

Background

Living kidney donation (LKD), where individuals donate one kidney while alive, plays a critical role in increasing the number of kidneys available for those experiencing kidney failure. Previous studies show that many generous people are interested in becoming living donors; however, a huge gap exists between the number of patients on the waiting list and the number of living donors yearly.

Objective

To bridge this gap, we aimed to investigate how to identify potential living donors from discussions on public social media forums so that educational interventions could later be directed to them.

Methods

Using Reddit forums as an example, this study described the classification of Reddit content shared about LKD into three classes: (1) present (presently dealing with LKD personally), (2) past (dealt with LKD personally in the past), and (3) other (LKD general comments). An evaluation was conducted comparing a fine-tuned distilled version of the Bidirectional Encoder Representations from Transformers (BERT) model with inference using GPT-3.5 (ChatGPT). To systematically evaluate ChatGPT’s sensitivity to distinguishing between the 3 prompt categories, we used a comprehensive prompt engineering strategy encompassing a full factorial analysis in 48 runs. A novel prompt engineering approach, dialogue until classification consensus, was introduced to simulate a deliberation between 2 domain experts until a consensus on classification was achieved.

Results

BERT and GPT-3.5 exhibited classification accuracies of approximately 75% and 78%, respectively. Recognizing the inherent ambiguity between classes, a post hoc analysis of incorrect predictions revealed sensible reasoning and acceptable errors in the predictive models. Considering these acceptable mismatched predictions, the accuracy improved to 89.3% for BERT and 90.7% for GPT-3.5.

Conclusions

Large language models, such as GPT-3.5, are highly capable of detecting and categorizing LKD-targeted content on social media forums. They are sensitive to instructions, and the introduced dialogue until classification consensus method exhibited superior performance over stand-alone reasoning, highlighting the merit in advancing prompt engineering methodologies. The models can produce appropriate contextual reasoning, even when final conclusions differ from their human counterparts.
Accuracy of Machine Learning in Discriminating Kawasaki Disease and Other Febrile Illnesses: Systematic Review and Meta-Analysis
Authors: Zhu Jinpu , Yang Fushuang , Wang Yang , Wang Zhongtian , Xiao Yao , Wang Lie , Sun Liping
Published: November 2024

Background

Kawasaki disease (KD) is an acute pediatric vasculitis that can lead to coronary artery aneurysms and severe cardiovascular complications, often presenting with obvious fever in the early stages. In current clinical practice, distinguishing KD from other febrile illnesses remains a significant challenge. In recent years, some researchers have explored the potential of machine learning (ML) methods for the differential diagnosis of KD versus other febrile illnesses, as well as for predicting coronary artery lesions (CALs) in people with KD. However, there is still a lack of systematic evidence to validate their effectiveness. Therefore, we have conducted the first systematic review and meta-analysis to evaluate the accuracy of ML in differentiating KD from other febrile illnesses and in predicting CALs in people with KD, so as to provide evidence-based support for the application of ML in the diagnosis and treatment of KD.

Objective

This study aimed to summarize the accuracy of ML in differentiating KD from other febrile illnesses and predicting CALs in people with KD.

Methods

PubMed, Cochrane Library, Embase, and Web of Science were systematically searched until September 26, 2023. The risk of bias in the included original studies was appraised using the Prediction Model Risk of Bias Assessment Tool (PROBAST). Stata (version 15.0; StataCorp) was used for the statistical analysis.

Results

A total of 29 studies were incorporated. Of them, 20 used ML to differentiate KD from other febrile illnesses. These studies involved a total of 103,882 participants, including 12,541 people with KD. In the validation set, the pooled concordance index, sensitivity, and specificity were 0.898 (95% CI 0.874-0.922), 0.91 (95% CI 0.83-0.95), and 0.86 (95% CI 0.80-0.90), respectively. Meanwhile, 9 studies used ML for early prediction of the risk of CALs in children with KD. These studies involved a total of 6503 people with KD, of whom 986 had CALs. The pooled concordance index in the validation set was 0.787 (95% CI 0.738-0.835).

Conclusions

The diagnostic and predictive factors used in the studies we included were primarily derived from common clinical data. The ML models constructed based on these clinical data demonstrated promising effectiveness in differentiating KD from other febrile illnesses and in predicting coronary artery lesions. Therefore, in future research, we can explore the use of ML methods to identify more efficient predictors and develop tools that can be applied on a broader scale for the differentiation of KD and the prediction of CALs.
The performance of large language models in Helicobacter pylori related medical counseling within a Chinese-language context: A comparative analysis (Preprint)
Authors: Zhang Mingjun , Jiang Xuan
Published: November 2024

BACKGROUND

Helicobacter pylori (H. pylori) infection is a global health issue, leading to a growing demand for medical counseling. Large Language Models (LLMs) have the potential to serve as valuable auxiliary tools for medical counseling. However, their performance in terms of accuracy, relevance, completeness, clarity, and reliability in providing H. pylori related medical counseling within a Chinese-language context remains unclear.

OBJECTIVE

This study aimed to evaluate the effectiveness of three LLMs: ChatGPT 3.5 turbo（OpenAI）, Kimi（Moonshot AI）, and Ernie Bot 3.5(Baidu, Inc), in providing H. pylori related medical counseling in a Chinese context.

METHODS

A total of 20 H. pylori related questions were included covering the following domains: definition and symptoms, diagnosis, treatment and prevention. Each question was being asked three times in Chinese to each LLM. An evaluation team of 3 physicians assessed the responses using a Likert scale across 5 dimensions: accuracy, relevance, completeness, clarity, and reliability, and came up with an overall assessment.

RESULTS

A total of 20 H. pylori related questions were included covering the following domains: definition and symptoms, diagnosis, treatment and prevention. Each question was being asked three times in Chinese to each LLM. An evaluation team of 3 physicians assessed the responses using a Likert scale across 5 dimensions: accuracy, relevance, completeness, clarity, and reliability, and came up with an overall assessment.

CONCLUSIONS

This study is the first to evaluate the effectiveness of various LLMs in H. pylori related medical counseling in a real-world setting. All the interactions were conducted in Chinese, not English, demanding a higher level of linguistic comprehension. The study showed that while the LLMs generally performed acceptably in accuracy, relevance and completeness, their clarity and reliability were less satisfactory. Kimi and Ernie Bot, both developed by Chinese companies, outperformed ChatGPT in some aspects of medical counseling in Chinese language. With the guidance of professionals, LLMs can serve as potential aids for medical counseling.
Jungle Treasure Hunt Board Game: Permainan Edukatif untuk Meningkatkan Durasi Atensi Anak Usia PAUD
Authors: Nurani Mahatma , Salsabila Maula , Natalie Helen , Wijaya Rio , Yulianto Jony
Published: November 2024

School readiness has emerged as one of pressing issues within the context of educational-focused community outreach. Preschool students often have short attention spans and this aﬀects their learning readiness at the elementary level. This issue warrants further intervention and by involving preschool students at TK Tunas Sawo, Sambikerep District, Surabaya, this community outreach program aimed to enhance preschool students’ attention spans. This study developed the Jungle Treasure Hunt Board Game as an intervention tool by combining play-based methods, storytelling, and token economy techniques to 4 preschool students in two consecutive sessions. The processes of community outreach followed the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). In the initial phase, a series of interviews and observations is conducted to assess students and to obtain basic information for the board game development. In the following phase, we worked with students to play board games. What follows is the post-intervention phase, where we conducted evaluation and determined the further action plans. The results showed that the preschool students demonstrated their ability to maintain their attention spans. At the end of the program, the stakeholders and psychologists validated and recommended this board game as an alternative educational tool for maintaining preschool students’ attention spans.
Pelatihan Penulisan Esai Destinasi Wisata di Kabupaten Gunungkidul bersama Komunitas Pelita
Authors: Cahyaningrum Dewojati  , Wulandari Ine
Published: November 2024

Abstrak
Kabupaten Gunungkidul merupakan salah satu daerah yang kaya akan objek wisata. Objek wisata yang terdapat di Gunungkidul berupa wisata alam, religi, kuliner, edukasi, sejarah, belanja, dan lain-lain berpotensi untuk memakmurkan masyarakat dari segi ekonomi dan budaya. Namun, banyak di antara objek wisata tersebut belum dikenal dan dikembangkan dengan maksimal. Dengan demikian, perlu langkah strategis berupa penggalian potensi wisata melalui tulisan yang ditulis oleh penulis lokal dan dipublikasikan ke masyarakat umum untuk memajukan potensi tersebut. Hal ini tidak saja berguna untuk pengembangan diri penulis, tetapi juga bermanfaat untuk pengembangan sektor pariwisata dan ekonomi masyarakat Gunungkidul. Oleh karena itu, kegiatan Pengabdian kepada Masyarakat (PkM) Fakultas Ilmu Budaya berupa penulisan esai ini sangat dibutuhkan oleh masyarakat setempat guna mengasah keterampilan kreatif. Berdasarkan latar belakang tersebut, tim PkM bekerja sama dengan Komunitas Pelita (Penggiat Literasi Aktif) Gunungkidul telah mengadakan Pelatihan Esai Destinasi Wisata di Kabupaten Gunungkidul. Anggota Komunitas Pelita terdiri atas guru SD, SMP, SMA, pegawai perpustakaan, pensiunan guru, dan masyarakat umum. Melalui pendampingan pada pelatihan ini, mereka telah menghasilkan buku antologi esai yang terdiri atas 37 tulisan tentang berbagai objek wisata Gunungkidul.
 
Kata Kunci: Pengabdian, pelatihan, esai, wisata, Gunungkidul
Analysis of the Performance and Influencing Factors of China's Carbon Market in 2022
Authors: Zhang Xuanmeng
Published: November 2024

China's carbon market is pivotal in the global battle against climate change, especially as the world's largest emitter of greenhouse gases. The establishment and effective management of this market are critical for advancing global environmental sustainability. Central to this effort is the carbon trade price (CTP), widely recognized as a key indicator of market fluctuations. In 2022, China's carbon market experienced significant turmoil, contrasting sharply with the resilience of the European carbon market, which demonstrated steady demand and price growth. This article reviews existing literature on the factors influencing CTP, identifying crucial elements such as environmental conditions, policy frameworks, market dynamics, and economic indicators that shape China's Emissions Trading System (ETS). A detailed analysis of these factors for the years 2021 and 2022 is provided. Additionally, I propose further factors that may impact the CTP and offer a series of policy recommendations aimed at enhancing the effectiveness and stability of China's carbon market.
Unveiling the Layers: Exploring Identity and Maternity in Suniti Namjoshi’s The Mothers of Maya Diip
Authors: Laspal Vasundhara , Rautela Barkha
Published: November 2024

This paper investigates the intricate layers of Identity and Maternity in Suniti Namjoshi's poignant novel, 'The Mothers of Maya Diip.' A critical exploration of the text unravels the complex web of relationships, cultural norms, and personal narratives that shape the protagonist's journey. By examining the intersections of feminism, queer identity, and motherhood, this analysis reveals how Suniti Namjoshi's work challenges traditional notions of love, family, and belonging. Ultimately, this study demonstrates the novel's powerful portrayal of the self as a multifaceted and dynamic entity and its enduring resonance in contemporary discussions of Identity and Maternity.
A Review On The He-Ne Laser System
Authors: Jalil Muhammad Arif Bin
Published: November 2024

Abstract: The first continuous-wave (CW) laser to be created was the He-Ne laser. Ali Javan and his colleagues W. R. Bennet and D. R. Herriott revealed the production of a cw He-Ne laser a few months after Maiman declared his invention of the pulsed ruby laser. Neon atoms are excited by helium atoms in this four-level gas laser. The laser light is produced by the neon's atomic changes. Red light with a wavelength of 632.8 nm is produced by these lasers' most popular neon transition. In addition to producing various UV and IR wavelengths, these lasers may also produce green and yellow light in the visible spectrum (Javan's first He-Ne operated in the IR at 1152.3 nm). It is feasible to make a given He-Ne's output work at a single wavelength by utilizing highly reflecting mirrors that are intended for one of these numerous possible lasing transitions.He-Ne lasers normally produce a few to tens of mW (milli-Watt, or 10−3 W) of power; they are not generators of high-power laser light. These lasers' extreme stability, both in terms of output light intensity (minimal jitter in power level) and wavelength (mode stability), is likely one of its most notable characteristics. He-Ne lasers are frequently used to steady other lasers for these reasons. They are also utilized in applications, like as holography, where mode stability is vital. He-Ne lasers dominated the market until the mid-1990s when they were manufactured for low-power uses, such as range finding, scanning, optical transmission, laser pointers, etc. However, due to lower costs, other types of lasers most notably semiconductor lasers seem to have emerged victorious in the recent rivalry. [30]
Um Relações entre competências socioemocionais, adaptabilidade e autoeficácia na transição escola-trabalho
Authors: Molina Costa Fabíola Aparecida , Melo-Silva Lucy Leal , Oliveira José Egídio , Lessa João Paulo A.
Published: November 2024

O objetivo deste estudo foi investigar possíveis correlações entre competências socioemocionais, adaptabilidade de carreira e autoeficácia na transição escola-trabalho. A amostra foi composta por 505 jovens aprendizes com idades entre 14 e 24 anos, sendo 39,4 % do sexo masculino (n = 199), 60,6 % do sexo feminino (n = 306), participantes de um programa de aprendizagem. Foram utilizados quatro instrumentos aplicados online: Instrumento para Avaliação de Competências Socioemocionais (SENNA 2.0), Escala de Adaptabilidade de Carreira (EAC), Escala de Autoeficácia na Transição Escola-Trabalho (AETBR), Questionário de Identificação e Critério de Classificação Econômica Brasil. Foram realizadas análises fatoriais confirmatórias, de confiabilidade, descritivas e correlações r de Pearson. Os resultados indicam correlações importantes entre todas as variáveis, exceto entre as competências socioemocionais, amabilidade e engajamento com os outros. Os resultados da AETT-BR e da EAC mostram relação entre confiança e adaptação. Os achados mostram implicações para as práticas e pistas para novas investigações.
Reprodução social de heróis: aspectos da instrumentalização da maternidade nos animês do tipo shounen My Hero Academia e Demon Slayer
Authors: Costa Leonardo , Ribeiro Regiane Regina
Published: November 2024

A presente pesquisa visa apontar características recorrentes na representação da maternidade e sua relação com o trabalho em personagens mães de dois animês do tipo shounen. Tem-se como fundamento teórico perspectivas sobre a maternidade nos animês, o contexto japonês sobre a divisão sexual do trabalho e aspectos como precariedade e vulnerabilidade no trabalho feminino. Aciona-se aqui, por meio da Análise Crítica de Narrativa, uma investigação sobre mães presentes nos animês My Hero Academia e Demon Slayer. Entre os resultados, percebeu-se que esse gênero narrativo, o shounen, cria situações que destituir as mães do poder de proteção e cuidado dos filhos em detrimento de forças do Estado;, demonizam ou antagonizam a figura materna; e, por fim, instrumentalizam a maternidade para enaltecer ou interromper o desenvolvimento narrativo dos filhos, personagens centrais.
O porvir imaginado pelo cinema brasileiro contemporâneo: a ficção científica no país do futuro
Authors: Barbosa Arthur Silva
Published: November 2024

Neste artigo em caráter ensaístico, propõe-se a análise da emergência de uma tendência contemporânea no cenário cinematográfico brasileiro, caracterizada pela representação de tempos e espaços especulativos – um elogio ao artifício e um apelo à imaginação enquanto potência criativa. Nesse contexto, gêneros previamente menos explorados no âmbito dessa cinematografia, como a ficção científica, ganham visibilidade. O objetivo central é compreender de que maneira esse gênero possibilita a expressão artística e crítica, além de assimilar tais narrativas em relação ao contexto contemporâneo em que estão inseridas. A abordagem adotada neste estudo busca uma compreensão abrangente do gênero narrativo, considerando tanto sua evolução histórica quanto uma análise contemporânea. Destaca-se a importância de examinar a especificidade da ficção científica, identificando suas características distintivas e suas convenções.
Expressionismo Alemão e estilo no especial de TV Lobisomem na Noite (2022)
Authors: Soares Anna Claudia
Published: November 2024

O expressionismo alemão é um movimento artístico e cinematográfico que emergiu na Alemanha durante o período entreguerras e impactou a linguagem cinematográfica, influenciando diretores e produções audiovisuais ao redor do mundo. Neste contexto, o especial de TV Lobisomem na Noite (2022) se destaca como um exemplo contemporâneo que busca resgatar e reinterpretar elementos característicos do expressionismo alemão. O episódio teve seu lançamento na plataforma de streaming Disney Plus e pertence ao universo de histórias em quadrinhos da Marvel Comics, sendo dirigido por Michael Giacchino. É perceptível a presença do estilo expressionista alemão no episódio, como por exemplo o uso intenso da luz e sombra de modo a definir os ambientes e o uso do rosto como expressividade. Portanto, utilizando a análise fílmica, esta pesquisa busca identificar as características do expressionismo alemão presentes no especial de TV Lobisomem na Noite (2022).
Especulando gênero(s): por uma abordagem queer dos estudos de gêneros cinematográficos
Authors: Rodrigues Marques Henrique
Published: November 2024

Partindo de reflexões interdisciplinares entre as teorias queer e os estudos culturais, este artigo se propõe a discutir novas possibilidades de definição do que é gênero cinematográfico.  Historicamente, os estudos de sexualidade e gênero (gender) no cinema sempre demonstraram grande afinidade pelos gêneros (genres). São abundantes os trabalhos que investigam a representação da mulher no melodrama, a sensibilidade queer no musical ou os discursos de masculinidades no western. Nesta pesquisa, concentramos a análise nos gêneros da ficção especulativa (horror, ficção científica e fantasia) e sua relação com debates da Teoria Queer. Malgrado esse vínculo profícuo entre os campos, que já nos rendeu importantes discussões sobre representações e discursos sobre gênero e sexualidade no audiovisual, pouco se refletiu sobre o modo como a perspectiva dissidente da teoria queer pode contribuir para a conceitualização de gênero em si. Frequentemente, esses trabalhos encaram o gênero cinematográfico de maneira hermética, enquanto uma estrutura bem definida e consolidada. Sendo assim, propomos uma queerização do gênero cinematográfico a partir da fricção das teorias de gênero cinematográfico de pesquisadores como Rick Altman, Steve Neale e Mark Jancovich, com conceitos da teoria queer. Acredita-se que tal concepção pode ser frutífera não apenas para os estudos queer no cinema, mas também para pesquisas de gênero cinematográfico na contemporaneidade de maneira geral.
A Revista
Authors: A Barca Equipe editorial
Published: November 2024

Apresentação do número 1 do volume 2 da revista A Barca.
Cavalo sem nome e paradeiro
Authors: Ferreira Benedito
Published: November 2024

Ensaio visual de Benedito Ferreira
A catalogação no sistema Pergamum segundo as orientações do RDA e LRM
Authors: Freitas Pamela Travassos de , Shintaku Milton , Cezar Josilaine Oliveira
Published: November 2024

Atualmente, as bibliotecas já se encontram automatizadas, com softwares cada vez mais avançados e repletos de recursos para seus clientes e com mais recursos para seus clientes, seguindo normas e códigos internacionais para tornar os dados intercambiáveis. Em 2010, foi introduzido o novo código de catalogação Resource Description and Access (RDA) que passou por diversas atualizações ao longo dos anos, necessitando que os softwares se adequassem ao novo padrão. Assim, o presente trabalho tem o objetivo de verificar se o software de gestão de bibliotecas Pergamum está em conformidade com os padrões internacionais, bem como avaliar se ele permite a catalogação de acordo com o RDA e os princípios da Library Reference Model (LRM). Para isso, foi realizada uma pesquisa experimental, buscando entender melhor o contexto. Como resultado, verificou-se que o Pergamum está preparado para catalogar obras seguindo as premissas do RDA e LRM, de modo satisfatório. Dessa forma, este estudo contribui para o avanço das pesquisas aplicadas à catalogação com RDA e LRM, além de explorar o uso do software Pergamum nesses processos.