bluuebunny/crossref_metadata_2025 huggingface dataset:
The white star apple (Chrysophyllum albidum G. Don), a revealed potential pan tropical forest food species in the context of climate and global changes
Authors: GANGLO Jean Cossi
Published: April 2022

Chrysophyllum albidum is a forest food tree species of the Sapotaceae family bearing large berries of nutrition, sanitary, and commercial values in many African countries. It naturally grows in lowland rain forest and is widely distributed in West, Central, and East Africa. Because of its socio-economic importance, C. albidum is threatened at least by human pressure. However, we do neither know at which extent climate change can impact its distribution, nor whether it is possible to introduce the species in other tropical regions. In order to resolve our concerns we decided to model the spatial distribution of the species. We then used the SDM package for data modelling in R to compare predictive performances of algorithms among the most common used: three machine learning algorithms (MaxEnt, Boosted Regression Trees, and Random Forests) and three regression algorithms (Generalized Linear Model, Generalized Additive Models, and Multivariate Adaptive Regression Spline). We performed model transfers in tropical Asia and Latin America. At the scale of Africa, predictions with respect to Maxent, under Africlim (scenarios rcp 4.5 and rcp 8.5, horizon 2055) and MIROCES2L (scenarios SSP245 and SSP585, horizon 2060) showed that the favorable areas of C. albidum will extend mostly in West, East, Central, and Southern Africa as well as in East Madagascar. As opposed to Maxent, in Africa, the predictions of BRT and RF were unrealistic with respect to the known ecology of C. albidum. All the algorithms were consistent in predicting a successful introduction of C. albidum in Latin America, both at present and in the future. Predictions of spatial distribution of C. albidum at present and in future under MIROCES2L, scenarios SSP245 and SSP585, horizon 2060 were coherent and even complementary between BRT and RF and showed that the species can be successfully introduced in tropical Asia.
Prognostic value of pericardial effusion in patients with STEMI treated with a pharmacoinvasive or a primary percutaneous intervention: From an experience of a tertiary center
Authors: Kiris Tuncay , Esin Fatma kayaltı , Avci Eyüp , Celik Aykan , Özkan Emel , Bayata Serdar , Karaca Mustafa
Published: April 2022

Background: The long-term prognostic relevance of pericardial effusion (PE) in ST-segment elevation myocardial infarction (STEMI) patients treated with a pharmacoinvasive or a primary percutaneous intervention (PCI ) strategy are not well established. The aim of this study was to investigate the prognostic impact of pericardial effusion in these patients.Methods: A total of 860 STEMI patients underwent a pharmacoinvasive or a primary PCI strategy were enrolled in this study. Echocardiographic, demographic, and laboratory data were collected. All-cause mortality was the primary end-point.Results: PE was present in 51 patients (5.9%). The patients with PE was higher long-term mortality rate compared with those did not (41% vs 27%, p = 0.0025). However, both multivarite analysis (HR:1.243, 95%CI: 0.765-2.022, p = 0.380) and propencity matching scores (40% vs 28%, p = 0.205) showed that there was no relationship between PE and long-term mortality.Conclusion: The presence of PE was not independent predictor of long-term mortality in STEMI patients treated with a pharmacoinvasive or a PCI.
PROTOKOL KURALLARININ KÖKENLERİ, DEVLET GELENEĞİNDEKİ YERİ VE HUKUKİ METİNLERE YANSIMALARI
Authors: BAYSAL Tahir
Published: April 2022

Devlet yönetiminin yasal hükümlere göre örgütlenmesi ve işleyişinin yasal kurallara dayalı olması, hukuk devleti olmanın en önemli kriteridir. Protokol kurallarının ilk olarak sarayda ve kilisede doğduğu düşünülmektedir. Saray içi ilişkileri ve davranış kurallarını belirleyen kurallar ile uluslararası ilişkilerde uyulması öngörülen kurallar, yönetim geleneğinin bir parçası olmuş ve protokol kurallarına dönüşmüştür. Protokol kuralları zaman içerisinde kamusal alanın geneline yayılmış, tüm kurum ve kuruluşlar ile bu kurum ve kuruluşlarda görev alan yönetici konumunda olsun ya da olmasın tüm memurlar için uyulması gereken temel kurallar halini almıştır. Protokol kuralları devletler, uluslararası kuruluşlar ve bürokratik kuruluşların saygınlığı açısından son derece önem arz etmektedir. Protokol kurallarına uygun olmayan davranışlar ya da işlemler hem kurumların hem de yöneticilerin saygınlığına gölge düşürme potansiyeli taşır. Bu derece önem arz eden protokol kurallarından bazıları zaman içerisinde hukuki metinler içerisinde de yer alarak yasal nitelik kazanmıştır. Mevzuatta yer alan protokol kuralları üç başlık altında toplanabilir: Etkinliklerde (tören, davet, resmi toplantı vb.) uyulması gereken usul ve esaslara ilişkin kurallar; gerçekleştirilen hizmetin saygınlığına uygun kıyafet seçimine ilişkin kurallar; resmi yazışma kuralları. Ulusal ve/veya kurumsal temsil ilkelerinin, saygınlık uyandırıcı dış görünüm standartlarının ve resmi yazışma kurallarının yasal metinlerle düzenlemiş olması, devlet geleneğinin de yönetim sürecinin asli unsurlarından biri olduğunu kanıtlamaktadır. Bu bakımdan geleneksel yönetim kuralları da kamu hukukunun temel kaynaklarından biri kabul edilebilir.
Mesenchymal Stem Cells Derived from Umbilical Cord Blood Having Excellent Stemness Properties with Therapeutic Benefits - a New Era in Cancer Treatment
Authors: Ray Suman Kumar , Mukherjee Sukhes
Published: April 2022

Mesenchymal stem cells (MSCs) are the most promising candidates for cellular therapies, and most therapeutic applications have focused on MSCs produced from adult bone marrow, despite mounting evidence that MSCs are present in a wide range of conditions. Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells, but its therapeutic potential extends beyond the hematopoietic component, which also suggests solid organ regenerative potential. With potential ranging from embryonic- like to lineage-committed progenitor cells, many different stems and progenitor cell populations have been postulated. MSC is currently inferred by numerous clinical applications for human UCB. As stem cell therapy kicks off some new research and these cells show such a boon to stem cell therapy, it is nevertheless characteristic that the prospect of UCB conservation is gaining momentum. Taken together, the experience described here shows that MSCs derived from UCB are seen as attractive therapeutic candidates for various human disorders including cancer. It is argued that a therapeutic stem cell transplant, using stem cells from UCB, provides a reliable repository of early precursor cells that can be useful in a large number of different conditions, considering issues of safety, availability, transplant methodology, rejection, and side effects. In particular, we focus on the concept of isolation and expansion, comparing the phenotype with MSC derived from the UCB, describing the ability to differentiate, and lastly, the therapeutic potential concerning stromal support, stemness characteristic, immune modulation, and cancer stem cell therapy. Thus it is an overview of the therapeutic application of UCB derived MSCs, with a special emphasis on cancer. Besides, the current evidence on the double-edged sword of MSCs in cancer treatment and the latest advances in UCB-derived MSC in cancer research will be discussed.
Synthesis and Antitumor Evaluation of Glutathione Responsive Self-Immolative
Disulphide Linked Camptothecin-Biotin Conjugate
Authors: Kaur Amardeep , Dhiman Shikha , Lee Hong Boon , Sharma Manu
Published: April 2022

Background:

Camptothecin is a naturally occurring alkaloid obtained from the stem wood of the Chinese
tree, Camptotheca acuminata. It exerts pharmacological effects due to its ability to selectively inhibit the type-I topoisomerase
DNA nuclear enzyme. Several semisynthetic analogs of camptothecin have been synthesized to date possessing
antitumor activity.

Objective:

Camptothecin (CPT) is one of the most promising anticancer drugs but it produces various side effects
because of its non-selectivity towards cancer cells. To overcome these adverse effects, we synthesized biotin conjugate
of camptothecin, which was linked via a self-immolative disulfide linker (CPT-SS-Biotin).

Method:

Biotin conjugated camptothecin linked through a disulfide bond was synthesized following schemes, and the
structural characterization was carried out. The stability and drug release studies were performed in the presence of
glutathione (GSH) while in vitro studies were performed on 4T1 tumor cell lines. In vivo pharmacological investigation
was done using an antitumor Wistar rat model.

Results:

The stability and drug release studies were performed in the presence of glutathione (GSH), and CPT-SSBiotin
was found to be physiologically stable moiety and can only be cleaved in the presence of GSH to release free
CPT. The CPT-SS-Biotin showed higher toxicity in the biotin-overexpressing 4T1 tumor cell line with a lower IC50
value (8.44 μM) compared to camptothecin alone (IC50 > 30 μM). CPT-SS-Biotin also showed 10.6% higher cellular
uptake by cells in comparison to free camptothecin. The CPT-SS-Biotin was delivered to cells by binding to the biotin
receptors on the cell surface, followed by energy-dependent endocytosis and internalization to cause cellular toxicity.

Conclusion:

In-vivo tumor suppression studies and in vitro cell line studies along with serological parameters and
histopathological studies showed that conjugate produced a high therapeutic effect and remarkably reduced toxic effects
in comparison to free CPT. The results suggested that biotinylation of camptothecin via disulfide linker can be a
safe and efficacious method in cancer therapeutics.
‘Convalescent Plasma’- An Effective Treatment Option to Prevent Emerging nCOVID-19- A Review
Authors: Ashique Sumel , Khatun Tahamina , Sahu Garima , Upadhyay Aakash , Adhana Archana , Kumar Shubneesh , Sandhu Navjot , Kumar Nitish
Published: April 2022

To date, no accepted therapy exists for treating the emerging infectious disease nCOVID-19 in a safe and effective way. Although various types of treatment options are under the developing phase around the world, among those, several studies concerning convalescent plasma (CP) from recovered patients reported promising effects against nCOVID-19 infected critically ill patients nowadays. The therapy showed very few adverse effects, and it helps to diminish the viral load when administered at an early stage of infection. Convalescent plasma appears to be safe for critically ill nCOVID-19 patients by decreasing serum viral loads, and most cases are virus negative after CP transfusion. The convalescent plasma can be good as it has already been utilized to treat previous pandemics like Ebola, influenza, and SARS-CoV infection. In this review article, we pointed out the background, rationality, mechanisms, and safety outcomes of CP to treat nCOVID-19 infected patients.
A study of physical fitness characteristics of junior wushu players depend on sex difference
Authors: Sukamti Endang Rini , Budiarti Ratna , Nugroho Wisnu , Miftachurochmah Yulvia , Azeem Kaukab
Published: April 2022

Physical fitness was an activity or exercise that can accelerate regeneration when performing several exercises or training. This study aimed to examine the physical fitness characteristics of male and female junior wushu players, followed by determining physical performance differences between both groups. The analytical observational study method was implemented to conduct this study using a cross-sectional approach Fifty junior wushu players (male: n= 25, height= 147.78 ± 12.96 cm; female: n= 25, height= 147.78 ± 12.60 cm) participated in this study by conducting some physical fitness tests. The results showed significant differences in the indicators of 20-meters running with a P-value of 0.049, backbend with a P-value of 0.000, and vertical jump P-value of 0.021. Meanwhile, there was no significant difference between male and female wushu players in the T-test, push up, sit up, dan sit reach (P0,05). From the results, it can be said that male players have higher scores in terms of weight, height, speed, and power, while female players have higher scores in terms of flexibility. This study concluded that it can be taken into consideration to optimize training and testing procedures for junior wushu players.
The Acceptability of Adherence Support via Mobile Phones for Antituberculosis Treatment in South India: Exploratory Study
Authors: Jose Nisha K , Vaz Clint , Chai Peter R , Rodrigues Rashmi
Published: April 2022

Background

India has the greatest burden of tuberculosis (TB). However, over 15% of the people on antitubercular therapy (ATT) in India are nonadherent. Several adherence monitoring techniques deployed in India to enhance ATT adherence have had modest effects. Increased adoption of mobile phones and other technologies pose potential solutions to measuring and intervening in ATT adherence. Several technology-based interventions around ATT adherence have been demonstrated in other countries.

Objective

The objective of our study was to understand the acceptance of mobile phone adherence supports for ATT using self-administered quantitative measures among patients with TB in South India.

Methods

This exploratory study was conducted at a TB treatment center (TTC) at a tertiary care center in Thrissur District, Kerala, India. We recruited 100 patients with TB on ATT using convenience sampling after obtaining written informed consent. Trained study staff administered the questionnaire in Malayalam, commonly spoken in Kerala, India. We used frequency, mean, median, and SD or IQR to describe the data.

Results

Of the 100 participants diagnosed with TB on ATT, 90% used mobile phones routinely, and 84% owned a mobile phone. Ninety-five percent of participants knew how to use the calling function, while 65% of them did not know how to use the SMS function on their mobile phone. Overall, 89% of the participants did not consider mobile phone–based ATT adherence interventions an intrusion in their privacy, and 93% did not fear stigma if the adherence reminder was received by someone else. Most (95%) of the study participants preferred mobile phone reminders instead of directly observed treatment, short-course. Voice calls (n=80, 80%) were the more preferred reminder modality than SMS reminders (n=5, 5%).

Conclusions

Mobile phones are likely an acceptable platform to deliver ATT adherence interventions among individuals with TB in South India. Preference of voice call reminders may inform the architecture of future adherence interventions surrounding ATT in South India.
PENGARUH NILAI TUKAR, PENANAMAN MODAL DALAM NEGERI (PMDN), DAN PENGELUARAN PEMERINTAH SEKTOR PENDIDIKAN TERHADAP PERTUMBUHAN EKONOMI DI INDONESIA
Authors: Wulandari Dessy Triaz , Soelistyo Aris , Kusuma Hendra
Published: April 2022

Economic growth is a matter of the economy in the long term and influenced by various factors in carrying out economic development. This study aimed to analyze the exchange rate, domestic investment, and government spending in the education sector on economic growth in Indonesia. The analytical method used in this research was the Multiple Linear Regression technique. For the purpose of analysis used secondary data from the 1999-2018 time series are used, namely Indonesian GDP data, exchange rate data, the value of domestic investment realization, and education sector government expenditure data. The data source of this research came from the official website of the Indonesian Statistics Agency, and sources from the research journal. The results showed the variables of exchange rates, domestic investment, and government spending in the education sector simultaneously and partially had a positive and significant impact on economic growth in Indonesia by the coefficient value of 0.0068, 0.0068 and 0.0000.
ANALISIS FAKTOR UPAH DAN MODAL TERHADAP PENYERAPAN TENAGA KERJA SEKTOR INDUSTRI KECIL MENENGAH KENDANG JIMBE KOTA BLITAR
Authors: Hanafi Muhammad Yusuf , Soelistyo Aris , Kusuma Hendra
Published: April 2022

Labor absorption is the large number of workers absorbed or working in a business or company. Increased employment will affect wages and capital. This writing has the aim to determine the effect of wages and capital on employment. The data analysis method used is multiple regression analysis on cross-section data to determine the effect of independent variables with the dependent variable. The first step in conducting regression is to test through the classical assumption test, including the normality test, the multicollinearity test, the heteroscedasticity, and autocorrelation test, and the statistical analysis of regression analysis. The results of the hypothesis proposed in this study, the two variables significantly influence the dependent variable. The wage variable has a significant and positive effect on labor absorption in Kendang Jimbe small and medium industries in Blitar City, capital variables have a significant and positive effect on labor absorption in Kendang Jimbe small and medium industries in Blitar City.
PENGARUH NILAI TUKAR KURS, PENANAMAN MODAL DALAM NEGERI (PMDN), DAN PENGELUARAN PEMERINTAH SEKTOR PENDIDIKAN TERHADAP PERTUMBUHAN EKONOMI DI INDONESIA TAHUN 1999-2018
Authors: Wulandari Dessy Triaz , Soelistyo Aris , Kusuma Hendra
Published: April 2022

Economic growth is a long-term economic problem that is influenced by various factors in implementing economic development. The purpose of this study was to analyze the effect of exchange rates, domestic investment, and government spending in the education sector on economic growth in Indonesia. The analysis technique used in this study is the Multiple Linear Regression technique. The research uses secondary data sources from the official Statistics Indonesia website and from previous research journals. The period used in this study was 20 years starting from 1999 - 2018. The results of the study showed that the variable exchange rate, domestic investment, and government spending in the education sector simultaneously and partially had a positive and significant effect on economic growth in Indonesia.
PENGARUH PMA, PMDN DAN PAD TERHADAP ANGGARAN BELANJA DI PROVINSI KEPULAUAN BANGKA BELITUNG TAHUN 2002-2017
Authors: Pane Adita Oktaria , Abdullah Mohammad Faisal , Boedirachminarni Arfida
Published: April 2022

Investments in an area can improve existing economies, both foreign investment and domestic capital investment. With the increasing economy there will increase revenue in an area anyway, so that with increasing income in an area can affect the budget. In addition, it can be seen from the level of investment in an area. The purpose of this research is to know the development of investment in Bangka Belitung Islands Province and how to influence the budget in Bangka Belitung Islands Province. Data used in the form of secondary data can be downloaded through the official website of BPS and DPMPTSP (Investment office and integrated one Door service) with a period of 16 years using multiple linear regression analysis techniques with Using Test T, Test f and coefficient of determination. The results gained that foreign investment was not significant and negatively affected the budget, domestic capital investment was not significant but positively influential towards the budget and significant local revenue Positive impact on the budget.
PENGARUH KEMISKINAN, PERTUMBUHAN EKONOMI, DAN PENGELUARAN PEMERINTAH TERHADAP KEMISKINAN DI KALIMANTAN TIMUR
Authors: Alviano Reynaldi , Nuraini Ida , Kusuma Hendra
Published: April 2022

In the province of East Kalimantan, poverty is a problem that still cannot be overcome. Poverty in the province of East Kalimantan from year to year is still high, which is not in line with economic growth which is also high in East Kalimantan compared to other Kalimantan Provinces. Poverty is high due to unemployment which is also high and government spending also affects poverty in East Kalimantan. The purpose of this research is to determine the effect of unemployment, economic growth, and government spending on poverty in East Kalimantan Province. The data used are secondary data derived from the statistical body (bps) of East Kalimantan and odjk of the finance ministry. The method of analysis uses panel data analysis and fixed-effect models. The results of this study indicate that simultaneous unemployment, economic growth, and government spending affect poverty in East Kalimantan Province. The unemployment variable has a positive and significant effect on poverty, the economic growth variable has a negative and significant effect on poverty, while the government expenditure variable has a negative and significant effect on poverty in East Kalimantan
ANALISIS PENGARUH MODAL, TENAGA KERJA DAN LAMA MELAUT TERHADAP PENDAPATAN NELAYAN PAYANG DI KELURAHAN BLIMBING KECAMATAN PACIRAN KABUPATEN LAMONGAN
Authors: Lestari Putri Indah , Arifin Zainal , Syaifullah Yunan
Published: April 2022

The purpose of this study was to determine how much the income of fishermen and the influence of capital, labor and sea time on the income of payang fishermen in Blimbing Village, Paciran District, Lamongan Regency. The data collection technique was by distributing questionnaires to 70 fishermen respondents, using simple random sampling method. The data processing technique used to test this research is to use the gross income formula TR=PXQ net income formula = TR-TC and analyze the data using multiple linear regression, hypothesis testing, and classical assumption. The results obtained by the average income received by payang fishermen is Rp. 250,282,857 in a month going to sea. While the results obtained from the results of the multiple linear regression equation are LogY=4.901+0.192Logx_1+0.910Logx_2+0.697Logx_3+e. The results showed that capital (X1), labor (X2) and sea time (X3) have a significant and positive effect on the income of payang fishermen in Blimbing Village, Paciran District, Lamongan Regency.
Analisis Perubahan Ekonomi Masyarakat Sesudah Dan Sebelum Adanya Obyek Wisata Kebun Teh Bah Butong, Sidamanik, Kabupaten Simalungun, Sumatera Utara
Authors: Aulia Nedra
Published: April 2022

The purpose of this study was to analyze changes in the community's economy after and before the opening of the Bah Butong Tea Garden tourism object to the public. The descriptive quantitative data analysis method includes descriptive variable tests and paired sample t-tests. The results of this study indicate that the paired t-test difference test on household expenditure variables type of work means there are significant differences after and before the opening of the Bah Butong Tea Garden tourism object to the public. Against residents who are tea farmers, traders, photographers, parking attendants, section heads, and public toilet guards at the Bah Butong Tea Garden tourism object after its opening to the public. There are economic changes that have a positive impact, namely increasing revenue from the tourism sector, increasing income from business activities carried out by the community at the Bah Butong Tea Garden tourism object, the production of food, beverages, parking tickets, entrance tickets, people already have permanent jobs and can increase their income. the standard of living of the people in the Bah Butong Tea Garden tourism object.
Pengaruh Pengeluaran Kesehatan, Dana Perimbangan, Dan Penduduk Miskin Terhadap Indeks Pembangunan Manusia Di Provinsi Papua Barat
Authors: Abdillah Fakhri , Wahyudi M.Sri
Published: April 2022

This study aims to determine the influence of goverment spending on education, balancing fund and the number of poor people on human development index (HDI). The data used in this study is secondary data for the period 2014-2019. human development index (HDI) as dependent variable, while goverment spending on education, balancing fund and the number of poor as Independent variables. The research method used is the analysis of the regression of panel data. The analysis tool uses Eviews9 which includes Chow test, Hausman test, normality test, multicollinearity test, heteroscedaticity. The results of this study are goverment spending on education has a positive and significant effect on human development index (HDI), balancing fund has a positive and significant effect on human development index (HDI), and the number of poor people has a negative and significant effect on human development index (HDI).
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI CADANGAN DEVISA DI INDONESIA
Authors: Fitria Norita , Soelistyo Aris , Susilowati Dwi
Published: April 2022

The purpose of this study is to analyze what factors affect foreign exchange reserves in Indonesia. The focus in this study is the variables that affect changes in foreign exchange reserves in the 1999-2019 period are non-oil and gas exports, the rupiah exchange rate, foreign debt and inflation as independent variables. Using an open economy model and Keynes's balance of payments, the analytical tools used in this study are the PAM regression model (Partial Adjustment Model) and the adaptive expectation model to see the long-term and short-term effects of the independent variable on the dependent variable. The results of this study show that simultaneously non-oil and gas exports, the rupiah exchange rate, foreign debt and inflation affect Indonesia's foreign exchange reserves, while partially non-oil exports and the rupiah exchange rate significantly and positively affect Indonesia's long-term and short-term foreign exchange reserves, while debt foreign exchange and inflation are not  significant and negatively affect long-term and short-term foreign exchange reserves. Non-oil exports, rupiah exchange rate, foreign debt and inflation can explain Indonesia's foreign exchange reserves of 97%, of which the remaining 3% is explained by other variables not included in this study.
Analisis Pengaruh Tingkat Pendidikan, Upah Minimum Provinsi dan Jumlah Industri Terhadap Kesempatan Kerja di Provinsi Jawa Timur tahun 1995-2020
Authors: Fara Eka Wahyuni Fara Eka Wahyuni , Riyanto Wahyu Hidayat , Sulistyono Setyo Wahyu
Published: April 2022

In national economic development, there is a gap between the growth of the workforce and the willingness of various economic sectors to absorb labor, making job opportunities still a major problem in the economy. Employment opportunities are influenced by several factors, namely the level of education, provincial minimum wage , and the number of industries. The purpose of this study was to determine the effect and analyze the variables of Education level, Provincial Minimum Wage , and Number of Industries on Employment Opportunities in East Java Province 1995-2020. This study uses the Multiple Regression analysis tool method with time series. The results of the study show that simultaneously the variables of Education Level, Provincial minimum wage, and Number of Industries have a significant effect on Employment Opportunities in East Java Province in 1995-2020. The coefficient of determination (R²) indicates that 95 percent of employment opportunities and the remaining 5 percent are explained by other variables not examined. Partially the level of education, Provincial Minimum Wage, and Number of Industries have a significant effect on Job Opportunities in East Java Province.
Artificial Intelligence and Machine Learning approach based in-silico ADME-Tox and Pharmacokinetic Profile of α-Linolenic acid from Catharanthus roseus (L.) G. Don.
Authors: Ramya S. , Soorya C. , Grace Lydial Pushpalatha G. , Aruna Devaraj , Loganathan T. , Balamurugan S. , Abraham GC. , Ponrathy T. , Kandeepan C , Jayakumararaj R.
Published: April 2022

Current craze and concomitant rise of Artificial Intelligence and Machine Learning (AI&ML) in the post-COVID-era holds significant contribution to Drug Design and Development. Along with IoT, AI&ML has reduced human interface and improved the Quality of Life though Quality-Health-Care products. AI&ML approaches driven Rational Drug Design along with customised molecular modelling techniques such as in-silico simulation, pharmacophore modelling, molecular dynamics, virtual screening, and molecular docking aims to elucidate unforeseen bioactivity of natural products confined to limited timeframe with at-most perfection. Besides, it also defines the molecular determinants that partake in the interface with in the drug and the target to design more proficient drug leads. α-Linolenic acid (ALA), a carboxylic acid with 18 carbons and three cis double bonds, is an essential fatty acid required for normal human health and can be acquired through regular dietary supplementation of food. During the metabolic process, ALA is bio-transformed into EPA and DHA. ALA decreases the risk of heart disease by maintaining normal heart rhythm and pumping. Studies suggest that ALA is associated with reduced risk of fatal ischemic heart disease further higher intake may reduce the risk of sudden death among prevalent myocardial infarction patients consistent with induced antiarrhythmic effect. It reduces blood clots, besides, cardiovascular-protective, anti-cancer, neuro-protective, anti-osteoporotic, anti-inflammatory, and anti-oxidative effects. However, data on pharmacological and toxicological aspects of ALA is limited; on the other hand, no serious adverse effects of ALA have been reported yet. In the present study AI&ML approach based in-silico ADME-Tox and pharmacokinetic profile of ALA from Catharanthus roseus is envisaged.

Keywords: IoT; AI&ML; ADME-Tox; α-Linolenic Acid (ALA); EPA; DHA Pharmacokinetics; Catharanthus roseus.
Variación espacio-temporal en la densidad y estructura de tallas de Megastraea undosa (Gastropoda: Turbinidae) en la costa occidental de Baja California Sur, México
Authors: Hernández-Padilla Juan Carlos , Navarro-González Jessica Adriana , Salcido-Guevara Luis A. , Sánchez-Cárdenas Rebeca , Gutiérrez-González José Luis , Yee-Duarte Josué Alonso
Published: April 2022

El caracol Megastraea undosa forma parte de las pesquerías de recursos bentónicos económicamente importantes de la costa occidental de Baja California Sur, México. Los estudios sobre su densidad y estructura de tallas son importantes debido a que forman parte de las evaluaciones de stock en apoyo al manejo de su pesquería. El objetivo de este trabajo fue determinar las variaciones espacio-temporales de la densidad y estructura de tallas del caracol M. undosa en la costa occidental de Baja California Sur, México. Se determinó la estructura de tallas por sitio de muestreo y se analizó con base en la talla mínima legal y por zona de pesca. En el análisis espacial, la densidad (ind. m-2) y talla promedio se analizaron por estrato de profundidad y zona de pesca. El análisis temporal, densidad y talla promedio fueron analizadas por estrato de profundidad, únicamente para la zona 3, en el periodo comprendido desde 1999-2014. Los resultados demostraron diferencias espaciales de la densidad y talla promedio del caracol M. undosa en la costa occidental de Baja California Sur, y en el sitio de pesca más sureño dominaron las tallas pequeñas. Se discuten las variaciones espacio-temporales de la densidad y estructura de tallas en función de la disponibilidad de macroalgas, así como de la temperatura superficial del mar y las surgencias estacionales. El conocimiento del comportamiento espacio-temporal de la talla y densidad de M. undosa servirá de base para su futuro manejo, con base en un enfoque biológico o bioeconómico para el establecimiento de puntos de referencia.
Annamalai’s Binomial Identity and Theorem
Authors: Annamalai Chinnaraji
Published: April 2022

This paper presents Annamalai’s binomial theorem, coefficient, identity,
and binomial expansion developed by Chinnaraji Annamalai of the Indian
Institute of Technology Kharagpur. Also, an extended geometric series is
introduced with innovative summation of single terms and more successive
terms of the series in this article.
MaxSpliZer: a Tool to Predict Effects of LDLR Splice Variants Based on the Maximum Entropy Model
Authors: Saadatagah Seyedmohammad , Shahnazar Reza , Sherafati Alborz , Alhalabi Lubna , Miller Alexandra A. , Hamed Marwan , Kullo Iftikhar
Published: April 2022

The Clinical Genome Resource Consortium (ClinGen) recommends MaxEntScan
(MES) model to predict effects of LDLR splice variants. We
developed “MaxSpliZer”, a software tool to automate implementation of
MES and validated it using ClinVar and UK-Biobank (UKBB) data. We tested
concordance of MaxSpliZer predictions with ClinVar classifications of
benign/likely benign (B/LB) and pathogenic/likely pathogenic (P/LP) for
LDLR variants with potential effect on splicing. We also
annotated LDLR splice variants in 200,618 UKBB participants,
categorizing them using MaxSpliZer as deleterious (n=90) and
non-deleterious (n=7,404). Low-density lipoprotein cholesterol (LDL-C)
levels were compared in these two groups after adjustment for lipid
lowering medication use. MaxSpliZer prediction was concordant with the
ClinVar classification in 128 of 138 P/LP variants (sensitivity 93%)
and 432 of 436 B/LB variants (specificity 99%). In the UKBB, splice
variants predicted as deleterious by MaxSpliZer had higher LDL-C than
non-deleterious splice variants (158.7±47.4 vs. 146.0±34.8mg/dL, p-value
= 0.014). Compared to manual curation time of 12±7 min per variant,
MaxSpliZer took 0.52±0.11 min for single entries and 1.5 s per variant
for biobank-scale data. MaxSpliZer, a software tool that implements MES
based on the ClinGen guideline, can accurately classify LDLR
splice variants in a rapid automated fashion.
Jesus and Prophetic Actions
Authors: MCKNIGHT SCOT
Published: April 2022

Historical Jesus studies today have focused on Jesus' role as prophet, but few have sought to define "what kind of prophet" Jesus might be. Since that same scholarship has usefully shaped its attention around the "actions" of Jesus, pursuing the "kind of prophet" Jesus is in light of actions narrows the evidence sufficiently. Accordingly, when one examines the so-called "prophetic actions" of Jesus, a coherent picture of Jesus as the eschatological prophet like Moses emerges. This study examines the prophetic actions of Jesus in light of the prophetic actions of the preclassical and classical prophets, as well as similar types of actions on the part of the Jewish popular movement prophets and Moses. While Jesus' actions show some similarities with the actions of the preclassical and classical prophets, his actions are more like the popular prophetic movements of the first century, especially as they evoke themes of Moses and Joshua, and his actions also show striking parallels with Moses' actions.
lncRNA-H19 in Fibroblasts Promotes Wound Healing in Diabetes
Authors: Yu Pijun , Guo Jian , Li Junjie , Shi Xiao , Xu Ning , Jiang Yongkang , Chen Wei , Hu Qin
Published: April 2022

Cutaneous wound healing in diabetes is impaired and would develop into nonhealing ulcerations. However, the molecular mechanism underlying the wound-healing process remains largely obscure. Here, we found that cutaneous PDGFRα+ fibroblast–expressing lncRNA-H19 (lncH19) accelerates the wound-healing process via promoting dermal fibroblast proliferation and macrophage infiltration in injured skin. PDGFRα+ cell–derived lncH19, which is lower in contents in the wound-healing cutaneous tissue of patients and mice with type 2 diabetes, is required for wound healing through promoting proliferative capacity of dermis fibroblasts as well as macrophage recruitments. Mechanistically, lncH19 relieves the cell cycle arrest of fibroblasts and increases macrophage infiltration in injured tissues via inhibiting p53 activity and GDF15 releasement. Furthermore, exosomes derived from adipocyte progenitor cells efficiently restore the impaired diabetic wound healing via delivering lncH19 to injured tissue. Therefore, our study reveals a new role for lncRNA in regulating cutaneous tissue repair and provides a novel promising insight for developing clinical treatment of diabetes.
Sacerización de estos tiempos, un artefacto para usurpar la democracia
Authors: Gallego Marín Carlos Arturo
Published: April 2022

Desde el Homo sacer: el poder soberano y la nuda vida y luego en Medios sin fin. Notas sobre la política, Agamben expone, apelando a la antigua Grecia, la dificultad original —si se quiere— del hecho de que esta civilización no disponía de un término único para expresar lo que nosotros queremos decir con la palabra vida. Y esta palabra está hondamente ligada a sacerización, dado que cuando esta se expresa, aquella se desvanece o, mejor, desaparece en su acepción más mínima. La sacerización (sacralización) es el fin de la vida, en la nuda vida. Dice nuestro autor (Agamben) que los términos que usaban los griegos eran semántica y morfológicamente distintos: zoé expresaba el simple hecho —continúa Agamben— de vivir que es común a todos los vivientes, mientras que bíos significaba la forma o manera de vivir propia de un individuo o de un grupo. Esta oposición desapareció gradualmente en las lenguas modernas sin dejar viva ninguna diferencia sustancial. Nos preguntamos por la expresión forma de vida entendiendo, sin desprendernos de Agamben, que esta se refiere al hecho de que una vida que no puede separarse nunca de su forma es una vida en la que nunca es posible aislar algo como una nuda vida. Entonces planteamos que, una vez reducida la vida a una nuda vida en la sacerización, la democracia queda en manos del latrocinio político y la corrupción, lo cual provoca paulatinamente su declive en tanto expresión popular originaria.
Factores educativos asociados al bajo rendimiento académico de estudiantes del Programa Flexible Aceleración del Aprendizaje
Authors: Mena Raga Yomelina
Published: April 2022

El presente artículo de investigación tiene como objetivo describir los factores educativos asociados al bajo rendimiento académico de los estudiantes del Programa Flexible Aceleración del Aprendizaje de la Institución Educativa Pedro Grau y Arola de la ciudad de Quibdó, departamento del Chocó. Para ello, se emplea una metodología cuantitativa con alcance descriptivo para dar a conocer los factores individuales, familiares y escolares que inciden en el bajo rendimiento académico. La técnica usada para este fin es la encuesta con un diferencial semántico de “sí” y “no” a un total de 26 estudiantes, 14 hombres y 12 mujeres, los cuales se encuentran en una edad promedio de 10 a 14 años. Para el análisis de la información, se emplea la estadística descriptiva e inferencial y se toman las respuestas de los 26 estudiantes a las 14 preguntas de la encuesta y, por medio de una codificación de 1 y 0, se valora cuál de las tres variables es la que más se acerca al bajo rendimiento.
Enfoque Estratégico Relacional en los debates marxistas sobre el estado
Authors: Romero Monroy Jorge Esteban
Published: April 2022

La siguiente reflexión apunta a introducir algunos aspectos relevantes de las teorías marxistas sobre el estado que se dieron a partir de la década de 1960, particularmente, aquellas que catalizaron y cimentaron lo que posteriormente conoceremos como enfoque estratégico relacional. Se afirma que este enfoque tiene su génesis en las discusiones que inició Nicos Poulantzas contra otras visiones marxistas del estado y que luego han sido desarrolladas y complementadas por el teórico Bob Jessop. Se resaltan algunos aspectos innovadores de este enfoque a fin de comprender la cada vez más compleja trama de relaciones que tienen curso en el estado contemporáneo.
Montaje, collage y ensamblaje en Un tigre de papel
Authors: Russo Eduardo A.
Published: April 2022

El artículo examina la presencia del montaje en sus distintas dimensiones en Un tigre de papel, (Luis Ospina, 2007). El montaje en los ámbitos cinematográfico y videográfico, el collage en diálogo con las artes visuales, y la práctica del ensamblaje, que redefine tanto la expansión del principio de montaje como la noción de dispositivo cinematográfico, son examinados en el film. Partiendo de la categoría del falso documental, Un tigre de papel se erige en un productivo ensayo sobre las relaciones entre documental y ficción, entre arte y revolución, entre historia y arte contemporáneo, que también reflexiona sobre los alcances del montaje
Innovations to Attribute Reduction of Covering Decision System Based on Conditional Information Entropy
Authors: Xia Xiuyun , Tian Hao , Wang Ye
Published: April 2022

Traditional rough set theory is mainly used to reduce attributes and extract rules in databases in which attributes are characterised by partitions, which the covering rough set theory, a generalisation of traditional rough set theory, covers. In this article, we posit a method to reduce the attributes of covering decision systems, which are databases incarnated in the form of covers. First, we define different covering decision systems and their attributes’ reductions. Further, we describe the necessity and sufficiency for reductions. Thereafter, we construct a discernible matrix to design algorithms that compute all the reductions of covering decision systems. Finally, the above methods are illustrated using a practical example and the obtained results are contrasted with other results.
Reliability of CSRS-PPP for Validating the Egyptian Geodetic Cors Networks
Authors: Abdallah Ashraf , Agag Tarek
Published: April 2022

The development, utilization, and maintenance of continuously operating reference stations (CORS) network are vital in many areas of surveying and geodesy, such as controlling geodetic networks, developing local ionospheric models, and estimating the tectonic plate movements. Accordingly, the Egyptian Surveying Authority (ESA) established a CORS network consisting of 40 stations covering the Nile valley and its delta in 2011. CORS collect global navigation satellite system (GNSS) data. Recently, Egypt has witnessed rapid growth in many infrastructure projects and the development of new cities on a national scale. Therefore, there is an urgent need to investigate the ESA-CORS accuracy; the quality of data from the ESA-CORS must be considered for monitoring continuous tectonic motion, coordinating changes, and for Egypt’s development plan. Contemporary research worldwide identified considerable benefits of the precise point positioning (PPP) solution of dual- or single-frequency GNSS data. This study investigates the reliability of using the CSRS-PPP service for three consecutive observation days of 32 ESA-CORS networks in Egypt and the surrounding six international GNSS services (IGS)-CORS. For ESA-CORS, the PPP solution showed a root mean square error (RMSE) value of 6 mm (standard deviation [SD] = 3–4 mm) in east and north; for the height direction, the solution indicated an RMSE value of 22 mm (SD was about 14 mm). At a confidence level of 95%, this study revealed that SD95% was 2 mm in east and north directions and 6–7 mm for the height direction. This study shows that the PPP solution shown from the ESA-CORS stations is associated with two times better for horizontal and four times for the height direction than the delivered form ESA-CORS stations.
Learning Context-based Embeddings for Knowledge Graph Completion
Authors: Pu Fei , Zhang Zhongwei , Feng Yan , Yang Bailin
Published: April 2022

Purpose

Due to the incompleteness nature of knowledge graphs (KGs), the task of predicting missing links between entities becomes important. Many previous approaches are static, this posed a notable problem that all meanings of a polysemous entity share one embedding vector. This study aims to propose a polysemous embedding approach, named KG embedding under relational contexts (ContE for short), for missing link prediction.

Design/methodology/approach

ContE models and infers different relationship patterns by considering the context of the relationship, which is implicit in the local neighborhood of the relationship. The forward and backward impacts of the relationship in ContE are mapped to two different embedding vectors, which represent the contextual information of the relationship. Then, according to the position of the entity, the entity's polysemous representation is obtained by adding its static embedding vector to the corresponding context vector of the relationship.

Findings

ContE is a fully expressive, that is, given any ground truth over the triples, there are embedding assignments to entities and relations that can precisely separate the true triples from false ones. ContE is capable of modeling four connectivity patterns such as symmetry, antisymmetry, inversion and composition.

Research limitations

ContE needs to do a grid search to find best parameters to get best performance in practice, which is a time-consuming task. Sometimes, it requires longer entity vectors to get better performance than some other models.

Practical implications

ContE is a bilinear model, which is a quite simple model that could be applied to large-scale KGs. By considering contexts of relations, ContE can distinguish the exact meaning of an entity in different triples so that when performing compositional reasoning, it is capable to infer the connectivity patterns of relations and achieves good performance on link prediction tasks.

Originality/value

ContE considers the contexts of entities in terms of their positions in triples and the relationships they link to. It decomposes a relation vector into two vectors, namely, forward impact vector and backward impact vector in order to capture the relational contexts. ContE has the same low computational complexity as TransE. Therefore, it provides a new approach for contextualized knowledge graph embedding.
Delayed setting time for alkali-activated slag composites using activator containing SiO2 and Na2O
Authors: Hung Chi-Che , Lin Wei-Ting , Yeih Wei-Chung , Chang Jiang-Jhy
Published: April 2022

This study examines the influence of SiO2 and Na2O mix proportions on the properties of alkali-activated slag (AAS) pastes. In order to solve the rapid setting problem associated with AAS, phosphoric or silicic acid is commonly added to the alkaline activator. The retarding effect of these additions suggests a close relationship between pH and setting time. In this study, AAS pastes with various SiO2 and Na2O dosages were analyzed. Regression analysis was carried out using pH value and setting time to identify the main parameters affecting the setting time. Results showed that the alkali modulus (i.e., the weight ratio of SiO2 over Na2O) is correlated with the pH value. Specifically, the initial and final setting times were significantly reduced under lower SiO2 and Na2O dosages. Therefore, a higher alkali modulus prolonged the setting time.
An Acoustic Sea Glider for Deep-Sea Noise Profiling Using an Acoustic Vector Sensor
Authors: Sun Qindong , Zhou Hongkun
Published: April 2022

An acoustic sea glider has been developed for ambient sea noise measurement and target detection through the deployment of an acoustic vector sensor (AVS). The glider was designed with three cabins connected in sequence and it can dive to depths exceeding 1200m. The AVS fixed on the glider measure acoustic pressure and particle velocities related to undersea noise, and the inner attitude sensors can effectively eliminate the estimation deviation of the direction of arrival. The inherent self-noises of the acoustic sea glider and AVS are presented respectively in respect to the Knudsen spectra of sea noise. Sea trial results indicate that the AVS could work well for undersea noise measurement when the glider is smooth sliding, and the target azimuth estimated by AVS after correction is remarkably consistent with the values measured by the GPS, and direction-finding errors are less than 10 degrees. The research in this paper shows that the acoustic sea glider is able to undertake tasks such as a wide range of underwater acoustic measurement and detection.