bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacokinetic Principles and Their Application to Central Nervous System Tumors
Authors: Straehla Joelle P. , Warren Katherine E.
Published: October 2020

Despite increasing knowledge of the biologic drivers of central nervous system tumors, most targeted agents trialed to date have not shown activity against these tumors in clinical trials. To effectively treat central nervous system tumors, an active drug must achieve and maintain an effective exposure at the tumor site for a long enough period of time to exert its intended effect. However, this is difficult to assess and achieve due to the constraints of drug delivery to the central nervous system. To address this complex problem, an understanding of pharmacokinetic principles is necessary. Pharmacokinetics is classically described as the quantitative study of drug absorption, distribution, metabolism, and elimination. The innate chemical properties of a drug, its administration (dose, route and schedule), and host factors all influence these four key pharmacokinetic phases. The central nervous system adds a level of complexity to standard plasma pharmacokinetics as it is a coupled drug compartment. This review will discuss special considerations of pharmacokinetics in the context of therapeutic development for central nervous system tumors.
Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications
Authors: Alven Sibusiso , Nqoro Xhamla , Aderibigbe Blessing Atim
Published: October 2020

Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.
Mechanical Properties of Coal Ash Particle-Reinforced Recycled Plastic-Based Composites for Sustainable Railway Sleepers
Authors: Ju Suhawn , Yoon Jinyoung , Sung Deokyong , Pyo Sukhoon
Published: October 2020

This experimental research investigates the mechanical properties of municipal plastic waste-based particulate composites reinforced with coal ash (CA), the by-product of thermal power plants, for sustainable railway sleepers. Six series of sustainable composites filled with inorganic mineral fillers, including CA, were prepared by a twin-screw extruder and a compression molding machine. The effect of mix design variables—such as filler type, contents and the particle size of the filler—on mechanical properties—including tensile, compression and flexural properties—and morphology were characterized. The scanning electron microscopy (SEM) was employed to examine the morphology of the composites, which revealed the uniform dispersion of fillers in the polymer matrix. The study results conclude that the recycled plastic-based composite with the addition of CA up to 60% is suitable for railway sleeper applications. This experimental study may provide new insight into the railway applications of the developed composites under service loading conditions including traffic loading and earthquake.
Testing Side-Scan Sonar and Multibeam Echosounder to Study Black Coral Gardens: A Case Study from Macaronesia
Authors: Czechowska Karolina , Feldens Peter , Tuya Fernando , Cosme de Esteban Marcial , Espino Fernando , Haroun Ricardo , Schönke Mischa , Otero-Ferrer Francisco
Published: October 2020

Black corals (order Antipatharia) are important components of mesophotic and deep-water marine communities, but due to their inaccessibility, there is limited knowledge about the basic aspects of their distribution and ecology. The aim of this study was to test methodologies to map and study colonies of a branched antipatharian species, Antipathella wollastoni, in the Canary Islands (Spain). Acoustic tools, side-scan sonar (SSS), and a multibeam echosounder (MBES), coupled with ground-truthing video surveys, were used to determine the habitat characteristics of Antipathella wollastoni. Below 40 m depth, colonies of increasing height (up to 1.3 m) and abundance (up to 10 colonies/m2) were observed, particularly on steep and current-facing slopes on rocky substrates. However, coral presence was not directly imaged on backscatter mosaics and bathymetric data. To improve this situation, promising initial attempts of detecting Antipathella wollastoni by utilizing the MBES water column scatter in an interval for 0.75 m to 1 m above the seafloor are reported.
Motion Capture Technology in Industrial Applications: A Systematic Review
Authors: Menolotto Matteo , Komaris Dimitrios-Sokratis , Tedesco Salvatore , O’Flynn Brendan , Walsh Michael
Published: October 2020

The rapid technological advancements of Industry 4.0 have opened up new vectors for novel industrial processes that require advanced sensing solutions for their realization. Motion capture (MoCap) sensors, such as visual cameras and inertial measurement units (IMUs), are frequently adopted in industrial settings to support solutions in robotics, additive manufacturing, teleworking and human safety. This review synthesizes and evaluates studies investigating the use of MoCap technologies in industry-related research. A search was performed in the Embase, Scopus, Web of Science and Google Scholar. Only studies in English, from 2015 onwards, on primary and secondary industrial applications were considered. The quality of the articles was appraised with the AXIS tool. Studies were categorized based on type of used sensors, beneficiary industry sector, and type of application. Study characteristics, key methods and findings were also summarized. In total, 1682 records were identified, and 59 were included in this review. Twenty-one and 38 studies were assessed as being prone to medium and low risks of bias, respectively. Camera-based sensors and IMUs were used in 40% and 70% of the studies, respectively. Construction (30.5%), robotics (15.3%) and automotive (10.2%) were the most researched industry sectors, whilst health and safety (64.4%) and the improvement of industrial processes or products (17%) were the most targeted applications. Inertial sensors were the first choice for industrial MoCap applications. Camera-based MoCap systems performed better in robotic applications, but camera obstructions caused by workers and machinery was the most challenging issue. Advancements in machine learning algorithms have been shown to increase the capabilities of MoCap systems in applications such as activity and fatigue detection as well as tool condition monitoring and object recognition.
Sleep Stage Estimation from Bed Leg Ballistocardiogram Sensors
Authors: Mitsukura Yasue , Sumali Brian , Nagura Masaki , Fukunaga Koichi , Yasui Masato
Published: October 2020

Ballistocardiogram (BCG) is a graphical representation of the subtle oscillations in body movements caused by cardiovascular activity. Although BCGs cause less burden to the user, electrocardiograms (ECGs) are still commonly used in the clinical scene due to BCG sensors’ noise sensitivity. In this paper, a robust method for sleep time BCG measurement and a mathematical model for predicting sleep stages using BCG are described. The novel BCG measurement algorithm can be described in three steps: preprocessing, creation of heartbeat signal template, and template matching for heart rate variability detection. The effectiveness of this algorithm was validated with 99 datasets from 36 subjects, with photoplethysmography (PPG) to compute ground truth heart rate variability (HRV). On average, 86.9% of the inter-beat intervals were detected and the mean error was 8.5ms. This shows that our method successfully extracted beat-to-beat intervals from BCG during sleep, making its usability comparable to those of clinical ECGs. Consequently, compared to other conventional BCG systems, even more accurate sleep heart rate monitoring with a smaller burden to the patient is available. Moreover, the accuracy of the sleep stages mathematical model, validated with 100 datasets from 25 subjects, is 80%, which is higher than conventional five-stage sleep classification algorithms (max: 69%). Although, in this paper, we applied the mathematical model to heart rate interval features from BCG, theoretically, this sleep stage prediction algorithm can also be applied to ECG-extracted heart rate intervals.
Textile Based Electrochromic Cells Prepared with PEDOT: PSS and Gelled Electrolyte
Authors: Graßmann Carsten , Mann Maureen , Van Langenhove Lieva , Schwarz-Pfeiffer Anne
Published: October 2020

Electrochromic devices can act as passive displays. They change their color when a low voltage is applied. Flexible and bendable hybrid textile-film electrochromic devices with poly-3,4-ethylenedioxythiophene polystyrene sulfonate (PEDOT:PSS) were prepared on polyethylene polyethylene terephthalate (PEPES) membranes using a spray coating technique. The electrolyte consisted of a gelatin glycerol mixture as host matrix and calcium chloride. Titanium dioxide was used as an ion storage layer and a carbon containing dispersion was used for the counter electrode on a polyester rip-stop fabric. The sheet resistance of PEDOT:PSS on PEPES was 500 Ohm/sq. A 5 × 5 electrochromic matrix with individually addressable pixels was successfully designed and assembled. The switching time of the pixels was 2 s at a voltage of 2.0 V directly after assembling. The use of titanium dioxide as ion storage also increased the contrast of the dark-blue reduced electrochromic layer. Coloration was not self-sustaining. The PEDOT:PSS layer needed a constant low voltage of at least 0.5 V to sustain in the dark-blue reduced state. The switching time increased with time. After 12 months the switching time was ~4 s at a voltage of 2.8 V. The addition of glycerol into the electrolyte extended the lifetime of a non-encapsulated textile electrochromic cell, because moisture is retained in the electrolyte. Charge carriers can be transported into and out of the electrochromic layer.
Baseline-Free Adaptive Crack Localization for Operating Stepped Rotors Based on Multiscale Data Fusion
Authors: Lu Zhiwen , Cao Shancheng , Yuan Rui , Lv Yong
Published: October 2020

Crack localization in running rotors is very important and full of challenges for machinery operation and maintenance. Characteristic deflection shapes or their derivatives based methods seem to be promising for crack localization in rotors. Despite the substantial advantages, several critical issues still need to be addressed to enhance the efficiency of this kind of method for practical applications. Two problems are considered in this work: 1. How to localize single or multiple cracks accurately avoiding the interference of commonly existing steps without baseline information on pristine rotors; 2. How to improve the crack localization performance under a noisy environment. To circumvent the issues, a novel baseline-free adaptive crack localization method is proposed based on data fusion of multiscale super-harmonic characteristic deflection shapes (SCDSs). In this method, crack induced asymmetry and nonlinearity of crack breathing are utilized to simultaneously eliminate the interference from the steps without a reference model. To enhance the noise robustness, the multiscale representations of SCDSs are made in Gaussian multiscale space, and Teager energy operator is applied to the multiscale SCDSs to amplify the crack induced singularities and construct the multiscale Teager super-harmonic characteristic deflection shapes (TSCDSs). Moreover, fractal dimension is designed as an evaluator to select the proper multiscale TSCDSs for data fusion adaptively. Then, a new damage index is derived for crack localization by Dempster-Shafer’s (D-S) evidence fusion of the adaptively selected multiscale TSCDSs. Finally, the feasibility and the effectiveness are verified by both numerical and experimental investigations.
Contact-Free Multispectral Identity Verification System Using Palm Veins and Deep Neural Network
Authors: Stanuch Maciej , Wodzinski Marek , Skalski Andrzej
Published: October 2020

Devices and systems secured by biometric factors became a part of our lives because they are convenient, easy to use, reliable, and secure. They use information about unique features of our bodies in order to authenticate a user. It is possible to enhance the security of these devices by adding supplementary modality while keeping the user experience at the same level. Palm vein systems are based on infrared wavelengths used for capturing images of users’ veins. It is both convenient for the user, and it is one of the most secure biometric solutions. The proposed system uses IR and UV wavelengths; the images are then processed by a deep convolutional neural network for extraction of biometric features and authentication of users. We tested the system in a verification scenario that consisted of checking if the images collected from the user contained the same biometric features as those in the database. The True Positive Rate (TPR) achieved by the system when the information from the two modalities were combined was 99.5% by the threshold of acceptance set to the Equal Error Rate (EER).
Parents’ Learning Mechanisms for Family Firm Succession: An Empirical Analysis in Spain through the Lens of the Dynamic Capabilities Approach
Authors: Martin-Cruz Natalia , Barros Contreras Ismael , Hernangómez Barahona Juan , Pérez Fernández Héctor
Published: October 2020

Succession is a concern for most family firms. The literature has addressed succession in family firms from different perspectives. However, there are still unaddressed questions concerning the microfoundations of succession, and there is a need to secure a better understanding of the succession process and what role parents play therein. Using the dynamic capabilities approach, we shed light on the influence of parents’ behaviors on successors’ intentions. In particular, the paper pursues a twofold aim; first, to analyze the effect of learning mechanisms that parents deliberately use with their children in the family firm on the succession dynamic capability; and second, to explore the impact of this dynamic capability of successor intention to continue in the family firm. We test the model on a sample of potential successors of family firms in Spain. Using partial least squares (PLS) for a sample of 9146 individuals, we confirm the positive impact of the use of parents’ deliberate learning mechanisms on succession dynamic capability and, in turn, the positive effect of the created succession dynamic capability on the successor’s intention to continue the family firm. Furthermore, we find that perceived self-efficacy fails to have any effect on successor intention.
Full Recycling of Asphalt Concrete with Waste Cooking Oil as Rejuvenator and LDPE from Urban Waste as Binder Modifier
Authors: Rodrigues Carlos , Capitão Silvino , Picado-Santos Luís , Almeida Arminda
Published: October 2020

Some research projects have studied full recycling of reclaimed asphalt pavement (RAP). Several additives have been used to rejuvenate the RAP’s aged bitumen. The authors previously studied full recycling of RAP rejuvenated with waste cooking oil (WCO). The asphalt concrete (AC) manufactured revealed good mechanical behaviour except for rutting resistance. Therefore, they decided to also include in the asphalt mixtures low density polyethylene (LDPE) from urban waste as a low-cost polymer to improve that weak point and verify if this technique was feasible and with potential as a pavement material. A laboratory plan was conceived to evaluate the mechanical performance of two rejuvenated ACs with WCO and LDPE. Stiffness, water sensitivity, resistance to rutting and fatigue cracking were evaluated. The results showed that, despite some empirical parameters usually indicated in current specifications not being met, the performance of the studied asphalt mixtures was adequate and, thus, there are good expectations about the future use of these solutions in real pavements, particularly for low and intermediate traffic levels. Based on a global analysis of the performance observed, the main conclusion was that full recycling of AC with WCO and LDPE is feasible, and the score obtained was higher than that of a conventional AC used for comparison.
Spanish Archaeological Museums during COVID-19 (2020): An Edu-Communicative Analysis of Their Activity on Twitter through the Sustainable Development Goals
Authors: Rivero Pilar , Navarro-Neri Iñaki , García-Ceballos Silvia , Aso Borja
Published: October 2020

On 18 March 2020, Spanish museums saw their in-person activities come to a halt. This paradigm shift has raised questions concerning how these institutions reinvented themselves and modified their edu-communicative strategies to promote heritage through active citizen participation. The present study centers on analyzing how the main Spanish archaeological museums and sites (N = 254) have used Twitter as an edu-communicative tool and analyzes the content of their hashtags through a mixed methodology. The objective is to identify the educational strategies for both transmitting information as well as interacting with users. We did it by observing and analyzing if Spanish archaeological institutions are promoting a type of quality, accessible, and egalitarian education and promoting the creation of cyber communities that ensure the sustainability of heritage through citizen participation. This paper proposes an innovative assessment of communication on Twitter based on the purpose of messages from the viewpoint of heritage education, their r-elational factor, and predominant type of learning. The main findings reveal a significant increase in Twitter activity, both in quantitative and qualitative terms: educational content is gaining primacy over the simple sharing of basic information and promotional content. The networks forge new ways to teach–learn and interact with media and represent a strong channel to promote the sustainability of heritage, its preservation, and appreciation.
Uncertainty Relations: Curiosities and Inconsistencies
Authors: Urbanowski Krzysztof
Published: October 2020

Analyzing general uncertainty relations one can find that there can exist such pairs of non-commuting observables A and B and such vectors that the lower bound for the product of standard deviations ΔA and ΔB calculated for these vectors is zero: ΔA·ΔB≥0. Here we discuss examples of such cases and some other inconsistencies which can be found performing a rigorous analysis of the uncertainty relations in some special cases. As an illustration of such cases matrices (2×2) and (3×3) and the position–momentum uncertainty relation for a quantum particle in the box are considered. The status of the uncertainty relation in PT–symmetric quantum theory and the problems associated with it are also studied.
VASMA Weighting: Survey-Based Criteria Weighting Methodology that Combines ENTROPY and WASPAS-SVNS to Reflect the Psychometric Features of the VAS Scales
Authors: Lescauskiene Ingrida , Bausys Romualdas , Zavadskas Edmundas Kazimieras , Juodagalviene Birute
Published: October 2020

Data symmetry and asymmetry might cause difficulties in various areas including criteria weighting approaches. Preference elicitation is an integral part of the multicriteria decision-making process. Weighting approaches differ in terms of accuracy, ease of use, complexity, and theoretical foundations. When the opinions of the wider audience are needed, electronic surveys with the matrix questions consisting of the visual analogue scales (VAS) might be employed as the easily understandable data collection tool. The novel criteria weighting technique VASMA weighting (VAS Matrix for the criteria weighting) is presented in this paper. It respects the psychometric features of the VAS scales and analyzes the uncertainties caused by the survey-based preference elicitation. VASMA weighting integrates WASPAS-SVNS for the determination of the subjective weights and Shannon entropy for the calculation of the objective weights. Numerical example analyzing the importance of the criteria that affect parents’ decisions regarding the choice of the kindergarten institution was performed as the practical application. Comparison of the VASMA weighting and the direct rating (DR) methodologies was done. It revealed that VASMA weighting is able to overcome the main disadvantages of the DR technique—the high biases of the collected data and the low variation of the criteria weights.
Contrasting Immunomodulatory Effects of Probiotic and Pathogenic Bacteria on Eastern Oyster, Crassostrea Virginica, Larvae
Authors: Modak Tejashree H. , Gomez-Chiarri Marta
Published: October 2020

Several Vibrio spp. cause acute and severe mortality events in hatcheries where larvae of bivalve mollusks are reared, potentially leading to subsequent shortage of bivalve seed for the grow-out industry. In particular, strains of Vibrio coralliilyticus have been identified as a major cause of disease in Pacific, Crassostrea gigas, and eastern, C. virginica, oyster hatcheries in the USA of America. Probiotic bacteria are an inexpensive, practical, and natural method of disease control. Previous research shows that pretreatment of larval oysters with probiotic bacteria Bacillus pumilus RI06–95 (RI) and Phaeobacter inhibens S4 (S4) significantly decreases mortality caused by experimental challenge with the bacterial pathogen V. coralliilyticus RE22 (RE22). This study aims to characterize the immune response of 6–10-day-old eastern oyster larvae to experimental challenge with pathogen V. coralliilyticus RE22 and probionts RI and S4. Treatments included (a) pathogen and probiont exposure at a concentration of 5 × 104 CFU per mL (~2500 bacterial cells per larva) for a duration of 6 h, (b) probiont exposure at the same concentration for a duration of 24 h, and (c) probiont RI daily treatment of larvae in the hatchery for 4, 11, and 15 days. Differential gene expression analysis compared pathogen or probiotic-treated transcriptomes to unexposed controls. Probiotic and pathogen treatment led to upregulation of transcripts coding for several immune pattern recognition receptors (PRRs) involved in environmental sensing and detection of microbes in oyster larvae. Larval oyster responses to pathogen RE22 suggested suppression of expression of genes in immune signaling pathways (myd88, tak1, nkap), failure in upregulation of immune effector genes, high metabolic demand, and oxidative stress that potentially contributed to mortality. On the other hand, the transcriptomic response to probiotic bacteria RI and S4 suggested activation of immune signaling pathways and expression of immune effectors (e.g., Cv-spi2, mucins and perforin-2). These key features of the host immune response to probiotic bacteria were shared despite the length of probiotic exposure, probiotic species, and the type of environment in which exposures were conducted. This study suggests that pre-exposure of eastern oyster larvae to probiotics for 6–24 h prior to pathogenic challenge leads to a robust and effective immune response that may contribute to protecting larvae from subsequent challenge with V. coralliilyticus RE22. This research provides new insights into host-microbe interactions in larval oysters that could be applied in the management of vibriosis in bivalve hatcheries.
Assessment of Surface Hydrological Connectivity in an Ungauged Multi-Lake System with a Combined Approach Using Geostatistics and Spaceborne SAR Observations
Authors: Chen Yueqing , Wu Lili , Zhang Guangxin , Xu Y. Jun , Tan Zhiqiang , Qiao Sijia
Published: October 2020

Connectivity metrics for surface water are important for predicting floods and droughts, and improving water management for human use and ecological integrity at the landscape scale. The integrated use of synthetic aperture radar (SAR) observations and geostatistics approach can be useful for developing and quantifying these metrics and their changes, including geostatistical connectivity function (GCF), maximum distance of connection (MDC), surface water extent (SWE), and connection frequency. In this study, we conducted a geostatistical analysis based on 52 wet and dry binary state (i.e., water and non-water) rasters derived from Sentinel-1 A/B GRD products acquired from 2015 to 2019 for China’s Momoge National Nature Reserve to investigate applicability and dynamics of the hydrologic connectivity metrics in an ungauged (i.e., data such as flow and water level are scarce) multi-lake system. We found: (1) generally, the change of GCF in North–South and Northeast–Southwest directions was greater than that in the West–East and Northwest–Southeast directions; (2) MDC had a threshold effect, generally at most 25 km along the W–E, NW–SE and NE–SW directions, and at most 45 km along the N–S direction; (3) the flow paths between lakes are diverse, including channelized flow, diffusive overbank flow, over-road flow and “fill-and-merge”; (4) generally, the values of the three surface hydrological connectivity indicators (i.e., the MDC, the SWE, and the conneciton frequency) all increased from May to August, and decreased from August to October; (5) generally, the closer the distance between the lakes, the greater the connection frequency, but it is also affected by the dam and road barrier. The study demonstrates the usefulness of the geostatistical method combining Sentinel-1 SAR image analysis in quantifying surface hydrological connectivity in an ungagged area. This approach should be applicable for other geographical regions, in order help resource managers and policymakers identify changes in surface hydrological connectivity, as well as address potential impacts of these changes on water resources for human use and/or ecological integrity at the landscape level.
Pregnancy protection and pregnancies in women prescribed ACE inhibitors or ARBs: a cross-sectional study in primary care
Authors: Lovegrove Elizabeth , Robson John , McGettigan Patricia
Published: October 2020

Background

The teratogenic risks of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are well documented, but prescribing these in younger women in primary care is becoming increasingly frequent.

Aim

To record how frequently women of childbearing age, who are prescribed an ACE inhibitor or ARB, receive preconception advice and/or are prescribed contraception, and how many pregnancies, terminations, and miscarriages occur in this population. Additionally, to ascertain whether patterns in the above differ across age groups.

Design and setting

Cross-sectional study conducted among patients from 141 general practices in East London.

Method

Women aged 15–45 years who were issued a prescription for an ACE inhibitor or ARB between 1 October 2018 and 1 January 2019 inclusive were included. An electronic search strategy was designed to extract pseudonymised data concerning preconception and contraception advice, contraception, and pregnancies from the electronic clinical system; this was applied to the selected cohort on 1 January 2019. Data were analysed in 5-year age groups.

Results

Of 302 939 women aged 15–45 years, 2651 (0.9%) were prescribed an ACE inhibitor or an ARB in a 3-month period. Of these, 2159 (81.4%) had no advice and no contraception prescription recorded, 35 (1.3%) had preconception advice recorded, and 230 (8.7%) had contraception advice recorded. A total of 100 pregnancies and 21 terminations/miscarriages were recorded in the 12 months preceding the index date (1 January 2019).

Conclusion

This study found that the recording of pre-pregnancy advice and contraception in women of childbearing age who were prescribed an ACE inhibitor or an ARB was suboptimal; this may place women and their babies at risk of exposure to teratogens during pregnancy. The findings indicate that there is a need for improved safety strategies based in primary care.
Group medical consultation for osteoporosis: a prospective pilot study of patient experience in Canadian tertiary care
Authors: Billington Emma O , Feasel A Lynn , VanDyke Jessica L , Kline Gregory A
Published: October 2020

Background

Delivery of patient-centred care is limited by physician time. Group medical consultations may save physician time without compromising patient experience.

Aim

To assess patient experience and specialist physician time commitment in a group consultation for osteoporosis.

Design and setting

Prospective pilot study at a tertiary osteoporosis centre in Canada between May 2016 and June 2019.

Method

The authors evaluated women referred for osteoporosis who chose a 2-hour group consultation instead of a one-to-one consultation. Group consultations were led by an osteoporosis nurse and specialist physician, and consisted of individualised fracture risk assessment and education regarding osteoporosis therapies, followed by a decision-making exercise to choose a treatment plan. Patients then followed up with their GPs to implement this plan. Patient experience was assessed via a questionnaire immediately and 3 months post-consultation, at which time GP satisfaction and patient treatment status were also surveyed.

Results

Of 560 referrals received, 18 patients declined osteoporosis specialist assessment, 54 could not be contacted, 303 attended a one-to- one consultation, and 185 attended a group consultation. Mean participant age was 62.8 years (standard deviation [SD] 5.8) and the Fracture Risk Assessment Tool (FRAX) 10-year osteoporotic fracture risk was 13.0 (SD 7.0)%. Immediately post-consultation, 104 (97.2%) patients were satisfied and 102 (95.3%) felt included in decision making. Satisfaction was reported by 95/99 (96.0%) patients and 27/36 (75.0%) GPs. Treatment plans had been enacted by 90 (90.1%) patients. For a matched number of individual consultations, each group session conferred a specialist physician time savings of 5.5 hours.

Conclusion

Group consultations represent a satisfactory and time-efficient alternative to one-to-one consultations for select patients with osteoporosis.
Analisis Perancangan Aplikasi Penjualan Souvenir Nusantara Berbasis Android
Authors: . Kelvin , Sitanggang Delima , . Efendy , . David , Siahaan Edivan Wasington
Published: October 2020

Souvenir adalah barang-barang kerajinan tangan yang merupakan hasil kreativitas para pengrajin dan diminati banyak orang, terutama para wisatawan. Penjualan Souvenir ini biasanya hanya dapat diperoleh jika melakukan kunjungan wisata ke daerah masing-masing sehingga tidak semua orang yang membutuhkan dapat memilikinya. Oleh karena itu kita memilih Penjualan online yang telah berkembang pesat dengan munculnya telepon seluler yang berbasis android sehingga penjual bisa memasarkan produknya secara online. Sedangkan pelanggan juga bisa memesan produk sesuai dengan kebutuhannya hanya dengan memiliki koneksi ke jaringan internet via telepon seluler yang memiliki sistem operasi android. Penjualan online sudah bisa dilakukan mulai pemajangan (display) produk mulai dari foto dan spesifikasi produk, yang nantinya data disimpan di database MySQL server, sehingga pelanggan bisa memilih produk yang diinginkan, memesannya dan melakukan pembayaran serta monitoring pengiriman secara online dari telepon seluler miliknya sehingga menghemat waktu dan biaya
IMPLEMENTASI DATA MINING UNTUK PENGELOMPOKKAN DAN PREDIKSI KARYAWAN YANG BERPOTENSI PHK DENGAN ALGORITMA K-MEANS CLUSTERING
Authors: Purba Windania , Siawin Willy , . Hardi
Published: October 2020

Penelitian ini dilakukan untuk mempelajari Data Mining dengan menggunakan algoritma K-MeanClustering yang diimplementasikan dalam perusahaan PT. Berlian Transtar Abadi untuk mengelompokkan dan melakukan prediksi terhadap karyawan yang berpotensi PHK. Data dikumpulkan dengan cara wawancara dan observasi terhadap pihak yang bersangkutan, selanjutnya data dianalisa untuk menentukan karyawan yang berpotensi PHK. Dari eksperimen yang dilakukan dengan menggunakanalgoritma K-means serta menggunakan software Visual Basic V10 dapat memberikan hasil yang akurat.
PENERAPAN METODE MONTE CARLO UNTUK SIMULASI SISTEM ANTRIAN SERVICE SEPEDA MOTOR BERBASIS WEB
Authors: Matondang Enjelika , Gultom Yeni , Sembiring Diarnia Mega Selfia , Aminatunnisa Siti , Indra Evta
Published: October 2020

Antrian merupakan suatu kegiatan dimana beberapa orang berbaris atau menunggu pada suatu fasilitas pelayanan kemudian dilayani, dan akhirnya meninggalkan fasilitas tersebut setelah dilayani untuk memenuhi sesuatu yang mereka inginkan. Antrian terjadi apabila waktu proses lebih besar dari pada waktu antar kedatangan. Simulasi sistem antrian adalah sistem informasi berbasis komputer yang digunakan untuk merancang  model suatu sistem antrian secara nyata guna memahami tingkah laku sistem tersebut. Secara umum, sistem antrian servis pada bengkel-bengkel masih dilakukan secara konvensional, sehingga banyaknya konsumen serta jadwal perbaikan sepeda motor  mengalami keterlambatan perbaikan. Untuk mengatasi masalah tersebut dalam penelitian ini akan dibangun aplikasi simulasi sistem antrian servis menggunakan  metode Monte Carlo berbasis Web yang diharapkan dapat meningkatkan kinerja pelayanan, dan mengurangi waktu tunggu konsumen sehingga pelayanan yang diberikan petugas kepada konsumen akan memberikan kepuasan tersendiri. Berdasarkan hasil penelitian terdapat perbedaan yang signifikan sebelum dan sesudah menggunakan sistem
SISTEM EDUKASI PENGENALAN WAKTU PADA ANAK USIA DINI BERBASIS MULTIMEDIA DI TAMAN KANAK-KANAK BUSTANUL ATHFAL MEDAN
Authors: David David
Published: October 2020

Pengenalan waktu sangat penting untuk diketahui oleh manusia. Pada zaman dahulu manusia mengenali waktu berdasarkan tanda-tanda alami yang ditunjukan oleh alam. Saat ini manusia mengetahui waktu dengan mempergunakan jam. Pengenalan waktu ini diajarkan pada anak-anak sejak dini melalui berbagai cara, antara lain dengan alat peraga. Adapun cara yang penulis ajukan adalah dengan mempergunakan media interaktif berupa permainan dimana cara ini lebih atraktif dibandingkan dengan metode konvesional. Sebelumnya diharapkan dengan adanya aplikasi ini siswa/siswi TK Bustanul Athfal Medan dapat mengenali waktu dengan benar.
Penerapan Sistem Antrian Registrasi dengan Metode Multi Channel-Multi Phase
Authors: Purba Antonius , Taufik Insan
Published: October 2020

Dalam memberikan pelayanan sistem antrian pasien di rumah sakit masih banyak ditemukan kendala dalam proses antrian, diantaranya  penumpukan pasien saat mengambil nomor antrian, antrian yang terlalu banyak dalam sistem antrian dan lamanya waktu menunggu dalam sistem antrian sehingga proses antrian dianggap memperlambat proses pelayanan. Oleh sebab itu penulis mengembangkan sistem antrian yang dilengkapi dengan jalur masuk pelayanan yang banyak dan sistem pelayanan yang banyak yang disebut dengan sistem antrian multi channel – multi phase. Penerapan model antrian multi channel – multi phase  membuat aplikasi dapat melayani lebih dari satu jenis layanan di rumah sakit dan dengan jalur masuk yang banyak yang dapat di sesuaikan dengan jenis dan jumlah unit pelayanan. Aplikasi  antrian  ini  juga  dilengkapi  dengan  pemanggil suara seperti aplikasi antrian yang telah ada saat ini dan bisa dilakukan perubahan atau penambahan jumlah dan jenis layanan sewaktu-waktu sesuai kebutuhan rumah sakit.

Keywords – queue, hospital, multi-channel multi-phase.
Ecological Consciousness and Self-Realization-- an Identification: A Step towards Spiritualistic World
Authors: Barman Dr. Mayuri
Published: October 2020

The most dangerous tendency of the present human generation is to enjoy every aspect of life selfishly which leads to serious threat to an environment. From the very beginning man was never a solitary creature in the planet where the relationship between humans and nature is one of the most fundamental issues we face and must deal with today. A universal holistic approach is needed, which may develop ecological consciousness among us. Many religions, scriptures can help to build a model of ecological consciousness. The importance of ancient Indian religious practices shows that human beings are an integral part of nature, and should, therefore, naturally understand the framework of life. At present human society is misled by the false attraction of the materialistic life, so to realize his true ‘self ,‘ one has to get out of this false notion that human society is the only proprietor of the world. The ‘Bhagavad-Gita’ nicely describes detachment from materials activities to the transcendental activities with realizing our true ‘self.’ Warwick Fox and Arne Naess’s ‘Self Realization’ shows how a person who Is self-realized and well-identified with the non-human world, will behave in harmony with nature, acting from inclination rather than duty.
‘HUATABAMPO ORO C2009’, NUEVA VARIEDAD DE TRIGO CRISTALINO PARA EL NOROESTE DE MÉXICO
Authors: Fuentes-Dávila Guillermo , Figueroa-López Pedro , Valenzuela-Herrera Víctor , Chávez-Villalba Gabriela , Félix-Fuentes J. Luis , Mendoza-Lugo J. Alberto
Published: October 2020

La producción mundial de trigo (Triticum sp.) en el año 2009 fue de 686.6 millones de toneladas (FAOSTAT, 2011a). China fue el mayor productor (115.1 millones), seguido por la India (80.6 millones); México produjo 4.1 millones de toneladas, de las cuales exportó 1.1 de trigo cristalino (FAOSTAT, 2011b). De la superficie total sembrada con trigo en el ciclo otoño-invierno 2008-2009 (457 419 ha) en el país, en los Estados de Sonora, Baja California, Sinaloa y Baja California Sur se sembró 64 %, con un valor de la producción de 4356 millones de pesos (SIAP, 2009). En esta región, el trigo es de hábito de crecimiento de primavera y se cultiva en condiciones de riego.
VIABILIDAD Y GERMINACIÓN DE SEMILLAS DE SEIS ESPECIES DE Tillandsia (BROMELIACEAE) DE OAXACA, MÉXICO
Authors: Sosa-Luría Diana , Chávez-Servia José L. , Mondragón-Chaparro Demetria , Estrada-Gómez Julio A. , Ramírez-Vallejo Porfirio
Published: October 2020

Para diseñar estrategias de conservación ex situ e in situ de los acervos genéticos mexicanos de las especies nativas de Tillandsia, es fundamental un mejor entendimiento de la ecofisiología de la semilla. Por ello, en este trabajo se evaluó la viabilidad y capacidad germinativa de la semilla de seis especies del género Tillandsia (Bromeliaceae). La semilla se recolectó de febrero a julio de 2010 en bosques de Santa Catarina Ixtepeji, Oaxaca. La viabilidad se midió mediante la prueba de rayos X y la germinación en una incubadora a temperatura constante de 25 ºC y fotoperiodo neutro. En ambas pruebas los tratamientos se distribuyeron en un diseño completamente al azar con un mínimo de seis repeticiones de 50 semillas. Los resultados se analizaron con comparación múltiple de medias y una correlacion de Pearson. Hubo diferencias (P ≤ 0.05) entre especies para porcentaje de semillas completas (viables o completamente desarrolladas) y de semillas con desarrollo incompleto. T. violacea presentó los más bajos porcentajes de semillas completas (61.3 %) y altos porcentajes de semillas con desarrollo parcial (31.6 %), en comparación con T. prodigiosa, T. carlos-hankii, T. bourgaei, T. makoyana y T. fasciculata que presentaron entre 68.3 y 89.0 % de semillas completas y entre 4.5 y 15.0 % de semillas parcialmente desarrolladas. T. bourgaei presentó el mayor porcentaje en su capacidad germinativa (83.3 %), seguida de T. makoyana (79.8 %), T. carlos-hankii (79.5 %), T. prodigiosa (75.8 %), T. fasciculata (45.0 %) y T. violacea (15.2 %). Hubo correlación positiva y significativa (r = 0.69, P < 0.05) entre los porcentajes de semillas completas y semillas germinadas.
RENDIMIENTO, CALIDAD DE FRUTO Y EFICIENCIA EN EL USO DEL AGUA DEL CHILE ‘MIRASOL’ BAJO RIEGO DEFICITARIO
Authors: Serna Pérez Alfonso , Zegbe Jorge A.
Published: October 2020

La disponibilidad de agua es la principal limitante ambiental para la producción de chile (Capsicum annuum L.) seco en el Norte Centro de México. El objetivo de este estudio fue comparar cuatro formas de riego deficitario (RD) con el riego completo (RC), con base en rendimiento, calidad del chile seco y eficiencia del uso del agua de riego (EUAR) en chile ‘Mirasol’ cultivado en una zona semiárida. Los tratamientos de RD fueron: 85 % (RD 85), 70 % (RD 70), 55 % (RD 55), y 40 % (RD 40) del RC. El ahorro promedio de agua en RD 85, RD 70, RD 55 y RD 40 fue de 8, 16, 23 y 30 %, respectivamente. El tratamiento RD 40 produjo el más alto porcentaje de fruta comercial, con rendimientos similares al RC en dos de los tres años evaluados. El RD 40 incrementó la EUAR, y redujo el volumen de agua aplicada en 1520 m3 ha-1 comparado con RC. Por tanto, este tratamiento podría ser una alternativa para el ahorro de agua en esta región semiárida y otras que enfrentan sobre-explotación de acuíferos, sin detrimento en la calidad del chile seco. No obstante, más estudios con RD para este cultivo son necesarios en áreas de baja o nula precipitación pluvial.
CURVAS DE ABSORCIÓN DE MACRONUTRIENTES EN CALABACITA ITALIANA (Cucurbita pepo L.)
Authors: Rodas-Gaitán Heberto A. , Rodríguez -Fuentes Humberto , Ojeda-Zacarías Ma. del Carmen , Vidales-Contreras Juan A. , Luna-Maldonado Alejandro I.
Published: October 2020

Mediante análisis químicos se determinaron las curvas de crecimiento y de absorción de algunos nutrimentos esenciales durante el ciclo de producción de la calabacita italiana (Cucurbita pepo L.), en un lote de producción comercial. La producción de biomasa seca total fue de 243 g/planta. Los datos de absorción de nitrógeno (N), fósforo (P), potasio (K), calcio (Ca) y magnesio (Mg) a través del tiempo se ajustaron a modelos lineales de regresión, cuyos coeficientes de determinación (R2) fueron: de 0.89, 0.92, 0.94, 0.78 y 0.72 para N, P, K, Ca y Mg, respectivamente. De acuerdo con la densidad de siembra (26 600 plantas ha-1), la absorción total (g/planta) de cada mineral fue: 6.75 N, 0.67 P, 1.37 K, 7.47 Ca y 2.07 Mg.
PENGELOLAAN KEUANGAN NEGARA
Authors: Amtiran Paulina Y , Molidya Aldarine
Published: October 2020

According to Law Number 17 of 2003 concerning State Finance, the President as the Head of Government holds the power to manage state finances as part of government power and power over the management of state finances is used to achieve state goals. However, to assist the Head of Government's duties, this power is delegated to the Minister of Finance, the Minister / head of the institution as the Budget User / Property User of the state ministries / institutions he leads and to the governor / regent / mayor as the head of the regional government.Financial management stages consist of planning, implementation, administration, reporting, accountability and supervision. Everything has been regulated in Law No.17 of 2003 on State Finance. In Law Number 17 of 2003 concerning State Finance, particularly articles 1 and 2, it is explained that what is meant by State Finance is all the rights and obligations of the state that can be valued in money, as well as everything in the form of money or in the form of goods that can be made state property related to the implementation of these rights and obligations.

Keywords: Management Of State Finances, Rights And Obligations
EKONOMI RUMAH TANGGA DI ERA PANDEMI COVID-19
Authors: Sina Peter Garlans
Published: October 2020

Covid-19 Pandemic which occurred in early 2020 has resulted in economic decline in Indonesia and the government also urges the public for a health protocol. The after effect is that MSMEs go bankrupt and there is a work termination so that more and more household economies experience life difficulties. There have been some assistances provided by the Government, but they have not been maximally increased the household economy until the new normal era. However, this condition must still be carried out in a management of all household resources which one of them is household finance and also the improvement of new skills.

 

Keywords : Household Economic, Health Protocol, Covid-19
Examining the Reasons behind the Successes and Failures of New Products: A Study of New Product Performances in Training Division of XYZ Management
Authors: Kurnia Pepey Riawati
Published: October 2020

Objective – New product performance is very important for the survival of any company. This research uses the Grounded Theory Method (GTM) to determine the factors that are relevant to the success and failure of new products. The study focuses specifically on new products in the Training Division of XYZ management.
Methodology/Technique – The data for this study was collected using the interview method with the total of 5 respondents, researcher’s involvement per se and FGDs.
Findings – The coding process resulted in the creation of 4 groups comprised of the 3 main questions containing 20 factors relevant to new product failure. These factors were previously confirmed by a survey conducted among 26 NPD practitioners from various industries. This research identifies that the steps involved in the development of new products have not been optimally conducted in accordance with the new product development guidelines. The results of this study explain the role of telemarketers and sales managers which can change and affect the performance of a new product.
Novelty - The involvement of the researcher as a telemarketer highlights the importance of the role and need of a reliable technological system to support the performance of new products. The findings of this research provide a greater understanding of the factors that contribute to product failure, namely a lack of a specific strategy for new products, less aggressive sales techniques, and the shifting role of telemarketers and sales managers.
Type of Paper: Empirical.
JEL Classification: M1; M11.

Keywords: New Product Performance; New Product Development Process; Sales Manager; Telemarketer.
Reference to this paper should be made as follows: Kurnia, P.R. 2020. Examining the Reasons behind the Successes and Failures of New Products: A Study of New Product Performances in Training Division of XYZ Management, J. Mgt. Mkt. Review 5(3) 129 – 140. https://doi.org/10.35609/jmmr.2020.5.3(1)