bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Dental Caries among School Going Children in Dolakha, Nepal
Authors: Mahanta Swagat Kumar , Prajapati Dilip , Khadka Anisha , Ghosh Snehashish , Ghimire Usha , Shahi Shirshak , Khimbaja Alina
Published: October 2023

IntroductionThere is a significant prevalence and morbidity of dental caries due to a lack of health education and insufficient preventive measures and the health status of students is not satisfactory. A number oforal disorders are linked to chronic diseases, and poor oral health has a major negative impact on overall health. People's everyday lives and general well-being are significantly impacted by pain, issues with eating, chewing, smiling, and communication brought on by missing, discolored, and damaged teeth. The aim of the study was to assess dental caries status among age groups, 3-14 years based on government and private schools.MethodsA cross-sectional comparative study done among 377 school going students age 3-15 years. Children from both private and public schools were included in the study. Dental caries status was assessed using the WHO oral health assessment form for children 2013.ResultsThe overall caries prevalence among the study participants was 341 (90.2%). Dental caries varied among age groups. Males scored higher dental caries levels than females. The private school students (5.78 ± 4.69) showed significantly higher levels of dental caries than the government school students (5.01 ±4.61).ConclusionsThe caries prevalence is very high in the school children of Dolakha with the highest burden among middle childhood age group with high number of untreated caries which emphasizes the need for further intervention.
Prevalence of Iron Deficiency Anemia among Under Five Years Children in a Tertiary Health Care Center of Nepal
Authors: Khanal Babita , Pokhrel Sandip , Singh Sandip Kumar , Yadav Sunil Kumar , Kafle Prakash
Published: October 2023

BackgroundGlobally 39.8% children under five years old are anemic, with prevalence of childhood anemia in Nepal reported to be 52.7% by 2016. The aim of this study is to analyze the prevalence of anemia among pediatric age group between 2 months to 60 months to provide some insight for prevention of anemia among children.
MethodsThis is a prospective observational cross-sectional study conducted over the period of 15st March 2019 to 14th August 2019 at Nobel Medical College Teaching Hospital which included children presenting to pediatric department between ages 2 to 60 months. Children with known history of hemolytic disorders, malignancies and chronic diseases were excluded from the study. Hemoglobin level and Mean Corpuscular Volume (MCV) was obtained. Descriptive statistics such as mean, percentage and standard deviation were calculated.
ResultsTotal 500 children selected randomly for the study, 234 (46.8%) children were non-anemic while mild anemia was seen in 86 (17.2%), moderate anemia in 155 (31.0%) and severe anemia in 25(5.0%) children. Mean hemoglobin was 10.2 gm/dl with standard deviation of 1.847. Among male 45.6% were anemic whereas 42.7%female were anemic. Children of age group 2 to 12 months had higher percentage of anemia with 76.2% being anemic.  Among 266 anemic children 219 (82.3%) had MCV below the normal range.
ConclusionOur study shows the higher prevalence of anemia in children between 2 to 60 months of age. Microcytic anemia was more common which represents higher prevalence of iron deficiency anemia among anemic children.
Clinical Profile and Outcome of Acute Pancreatitis in a Tertiary Health Care Center of Nepal
Authors: Gautam Ajay Kumar , Dewan Khus Raj , Shrestha Rishab , K.C. Vijaya
Published: October 2023

IntroductionAcute pancreatitis is the inflammation of pancreatic parenchyma that can cause local and systemic manifestations. This study aimed to find the clinical profile and an outcome of acute pancreatitis among patients attending the Department of Gastroenterology in a tertiary care center.MethodsA cross-sectional hospital based study comprising of 75 patients of acute pancreatitis, enrolled between August 2022 to June 2023. Clinical profile, complications and outcomes including in hospital mortality were studied. Revised Atlanta classification and modified CT severity index were used for diagnosis and classification. Data entry and analysis were done SPSS-17.ResultsMost common age group was 40-60 years (50.7%). The most common etiology was alcohol (46.7%) and almost all presented with abdominal pain (97%) and abdominal tenderness was present in 80%. Majority were mild pancreatitis (54.7%), followed by moderately severe (32%) and severe pancreatitis (13.3%). Factors that are significantly associated with prolonged stay at hospital and mortality were pleural effusion, necrotizing pancreatitis, acute kidney injury, BISAP score ≥ 2, high total leucocyte count, shock, severe CT severity score, multi organ dysfunction syndrome (MODS), acute respiratory distress syndrome (ARDS)(p≤0.05).ConclusionsAcute pancreatitis is predominant in male gender and 40-60 years age group. It is associated with significant complications and mortality. Different parameters including high BISAP score, pleural effusions, acute kidney injury, leucocytosis and high CRP level on presentation were useful markers to predict outcome.
Outcome of Surgical Management of Ipsilateral Femur and Tibia Fracture: The Floating Knee Injury
Authors: Gupta Hemant Kumar , Lamichhane Suman
Published: October 2023

IntroductionFloating knee injuries are one of the rare injuries of the lower limb involving fracture of ipsilateral femur and tibia. These injuries are often associated with other systemic injuries and have higher incidence of morbidity and mortality. Often times these fractures can pose difficulty in achieving union and might have residual stiffness around the knee. This study was carried out to assess the functional and radiological outcome of surgical management of floating knee injuries and the associated complications.MethodsA hospital based prospective study including 34 cases of surgically managed floating knee injuries over a period between January, 2017 and December, 2019 with the mean follow-up duration of 15 months was performed. The final outcome was evaluated on the basis of Karlstorm and Orelud criteria.ResultsFinal analysis was done based on the Karlstorm and Orelud criteria after the bony union was achieved. Based on the Karlstorm and Orelud criteria, 44.11% cases had excellent outcome, 29.41% cases had good outcome, 14.7% cases had a fair outcome and 11.76% cases had a poor outcome.ConclusionsFloating knee injuries are severe injuries often associated with polytrauma. Operative management in these complex injuries can yield favorable functional outcome with fewer complications.
Factores clínicos asociados con mortalidad y multirresistencia en pacientes quirúrgicos de un hospital de alta complejidad
Authors: Lorduy Gómez Jaime Alberto , Díaz Beltran Giovanny Raúl , Carrillo González Stephanye de Jesús , Muñoz Calderón Marianella
Published: October 2023

Introducción: el aumento de la morbimortalidad causada por gérmenes multirresistentes debido a la dificultad cada vez mayor para encontrar opciones de tratamiento, hace que hoy sea importante la identificación de los principales factores clínicos que se asocian con multirresistencia en pacientes quirúrgicos. Objetivo: determinar los factores clínicos relacionados con mortalidad y multirresistencia en quienes se someten a procedimientos quirúrgicos en un hospital de alta complejidad en Cartagena, Colombia. Materiales y Métodos: estudio descriptivo de corte transversal retrospectivo, con muestra proyectada de 150 pacientes quirúrgicos que cumplieran con los criterios de elegibilidad, a quienes se realizaron análisis uni y bivariados para establecer asociación entre muerte e infección por bacterias multirresistentes. Resultados y discusión: los factores clínicos asociados estadísticamente con mortalidad, en su mayoría se relacionan con antecedentes como hipertensión (p=0,001), anemia (p=0,044) e inmunosupresión (p=0,012), y con la multirresistencia son anemia (p=0,009), insuficiencia cardiaca (p=0,017) y ser de procedencia urbana (p=0,013) Conclusiones: la mortalidad de pacientes quirúrgicos se asocia de manera importante con los antecedentes clínicos y la multirresistencia no está determinada por los procedimientos médicos, ni por el tipo de intervención quirúrgica.
Model of Hydraulic Conductivity, Infiltration Rate, and Permeability at Gold Mine Waste Dump in North Sulawesi, Indonesia
Authors: Agustin Friska , Pratono Landy , Andriansyah Rian , Retongga Nofrohu , Umar Emi Prasetyawati
Published: October 2023

The research area is a gold mine operating in North Sulawesi. The aim of the study was to analyze and calculate hydrological parameters, namely: hydraulic conductivity, infiltration rate, and permeability to find out how strong the soil cover is at one level of waste disposal. The method used is the Measurement of hydraulic conductivity, infiltration rate, and permeability in the field, analysis, and calculation of hydraulic conductivity, infiltration rate, and permeability based on field data. In the designated regions of the waste dump, specifically areas 1a, b, and c, we observed certain hydrological patterns that are worth noting. Firstly, the hydraulic conductivity in these areas, which is a crucial determinant of the rate at which water can move through the soil, consistently showcased low average values. This is further supported by the similarly slow infiltration rate identified in the same zones. The ability of the soil to transmit water, i.e., its permeability, also followed this trend, with values leaning towards the lower end of the scale, indicating very slow permeability. One major contributory factor to these patterns appears to be the soil's composition. Predominantly made up of sandy loam, the soil in these areas exhibits high water retention capabilities. Sandy loam, by its nature, binds and retains water effectively, which could potentially explain the observed hydrological behaviors in waste dump areas 1a, b, and c.
Analysis of Maximum Economic Length of Soil Nail for Slope Stability
Authors: Pathak Bhashkar
Published: October 2023

Slope stability is of utmost importance in geotechnical engineering, necessitating effective reinforcement methods to mitigate failures. This study examined the advantages, limitations, and overall suitability of soil nails and cable anchors in stabilizing slopes. Numerical modeling and analysis were performed using the Rocscience Slide2 program. The study analyzed soil nails and cable anchors for slopes of 10 m to 60 m height, slope angle from 35° to 90°, and friction angle from 27° to 36°. The findings reveal that the maximum economic length of soil nails decreases as slip surface depth, slope height, and slope angle increase. Additionally, the friction angle of the soil has a negligible effect on the maximum economic length of the soil nail.
Geotourism Assessment using the M-GAM method (Modified Geosite Assessment Model) Sawahlunto Region, West Sumatra
Authors: Dezilia Dieny , Harnani Harnani
Published: October 2023

The geological setting in the area is a strong attraction for natural tourism. The Sawahlunto Geopark area is one of the Geoparks located in West Sumatra Province which has a variety of geological sites. This area meets the criteria that make it a potential Geopark. The purpose of this analysis is to evaluate the potential of geotourism and use this assessment as a basis for developing geotourism in the Sawahlunto and surrounding geotourism areas. This analytical study was carried out using the M-GAM (Modified Geosite Assessment Model) method. In the study process, research methods were carried out using questionnaire data based on 27 indicators from the M-GAM method.M-GAM method has 27 indicators consisting of main and additional values that will be used as a questionnaire which will produce quantitative results. The 27 indicators contain several geotourism assessments, including scientific value, aesthetic value, protection value, functional value, and tourism value of a geosite. The maximum score that can be obtained by a geosite that has all the perfect criteria in 27 indicators will get a main score of 12 and an additional score of 15. 7 geosites will be assessed with results, namely Batu Runciang (8.17 and 7.62), Serpih Bakelok (6.35 and 7.72), Tabiang Tinggi (6.81 and 8.14) and Puncak Cemara (8.19 and 8.41), Stone Garden (6.37 and 7.96), Batu Gantuang Cave (3.91 and 6.07) and Kubang Waterfall (3.48 and 6.48). Referring to the results of the Sawahlunto geosite assessment, it was concluded that the Batu Runciang and Puncak Cemara Geosites had a high value in terms of main values compared to the other 5 geosites. Meanwhile, for additional value, Tabiang Tinggi and Puncak Cemara have sufficient value compared to the other 5 Geosites. This is because geosites with low value still lack various things such as facilities and promotions. Efforts that can be made are to build facilities at several geosites that still experience a lack of public facilities. Apart from that, promotion on social media is also very helpful in introducing geosites to the public.
Seroprevalence in patients presenting with a pre-diagnosis of Toxoplasma gondii, Turkey
Authors: ASLANER Burcu , NALBANTOĞLU Serpil , YÜCESAN Banuçiçek
Published: October 2023

Toxoplasma gondii is a unicellular protozoan parasite. With this study, the aim was to evaluate the T. gondii test results that came to the General Directorate of Public Health, National Parasitology Reference Laboratory between January 2019 and December 2020. The seroprevalence were studied with the Sabin-Feldman Dye Test which is gold standard, Anti-T. gondii IgG and IgM and T. gondii IgG avidity with ELISA were evaluated. The distribution of cases according to gender and age groups was also evaluated statistically. In this study, SFDT was performed on 589 patients from 1160 patients with suspected Toxoplasmosis samples and Anti-T. gondii IgG and IgM tests were studied by ELISA in 478 patients. IgG avidity test by ELISA was performed on 93 cases with positive Anti- T. gondii IgG. In addition to these, cases in which Anti-T. gondii IgM and IgG were studied together and were positive were also evaluated. The number of samples both positive together was 17 (3.6%). According to Anti-T. gondii IgG/IgM results, no significant relationship was found between toxoplasmosis and gender. Moreover, of 93 cases with positive Anti-T. gondii IgG values, 71% had high avidity, 16% had cutoff value and 13% had low avidity. Further studies and surveillance studies should be performed to determine the epidemiology and current prevalence of toxoplasmosis.
Habilidades directivas: diseño instrumental y modelo para educación primaria en Durango, México
Authors: Hernández Jacquez Luis Fernando , Ríos Zavala Aída del Carmen
Published: October 2023

Este artículo tiene el objetivo de determinar la estructura dimensional de un modelo y un instrumento para medir el nivel de habilidades directivas de los directores de educación primaria del estado de Durango en México. Se tomó como referente teórico el modelo de habilidades esenciales de Whetten y Cameron y los dominios, criterios e indicadores del perfil del director de la Nueva Escuela Mexicana. Con base en el paradigma pospositivista y en el enfoque cuantitativo, se llevó a cabo un estudio no experimental y transversal de tipo instrumental, que empleó como técnica la encuesta administrada a un total de 426 directores(as). Los resultados conforman un modelo estructural de siete dimensiones y un instrumento integrado por 32 ítems. Las dimensiones fueron denominadas: solución de conflictos, manejo de emociones, logro de objetivos, comportamiento personal, apoyo, desempeño y trabajo en equipo. Las medidas de bondad de ajuste del modelo propuesto permitieron precisar su aceptabilidad. La confiabilidad final del instrumento arrojó un alfa de Cronbach de .946. Esto y las demás propiedades psicométricas presentadas hacen del modelo y del instrumento herramientas valiosas para el estudio de la temática.
Participatory evaluation of tomato (Lycopersicon esculentum Mill.) varieties under irrigation conditions at Abergelle district, Eastern Amhara
Authors: Mihiretu A. , Asresu M.
Published: October 2023

Participatory on-farm evaluation of improved tomato varieties (‘Melka salsa’, 'Roma VF' and 'Kochero’) against the local tomato variety was carried out during the 2019/2020 growing season involving six farmers of Abergelle district, Eastern Amhara. The objective of the experiment was to assess the performance of different tomato varieties for the farmers, then to collect their feedback. Based on the actual and farmers’ preference data, the analysis underscores the better performance of improved tomato varieties over local varieties by most yield-related attributes. Average marketable fruit yields of ‘Melka salsa’, ‘Roma VF’, ‘Kochero’, and the local variety were 4.62, 3.88, 3.64, and 3.10 ton ha-1, respectively. The improved varieties thus had a yield advantage of 72.38%, 37.14%, and 25.72% over the local variety in that order. Among improved tomato varieties, ‘Melka salsa' provided the highest fruit yield on top of owing the highest score of overall preference attributes rank. Scale-wide diffusion of ‘Melka salsa’ tomato variety is therefore suggested for similar and potential agro-ecologies. Biological scientists also should take farmers’ preference attributes and feedback as a backup for future breeding and adaptation studies on tomato varieties.
Genotypic difference of garlic (Allium sativum L.) cultivars for growth, bulb yield and yield related attributes at Tigray Province, Northern Ethiopia
Authors: Biratu W. , Molla B. , Abebe H. , Gebremeskel H.
Published: October 2023

The experiment was conducted at Ofla district from June to October of 2017 and 2018 cropping season to select high yielding and adaptable garlic cultivar(s). Six garlic cultivars namely Chefe, Tsedey, Holeta local, Kuriftu and Bora-4 and one Ofla Local were evaluated. The experiment was arranged in completely randomized block design (RCBD) with three replications. Different growth, phenology, yield and yield related data were collected. Leaf length, leaf width, bulb diameter and length were significantly (p<0.05) influenced by garlic cultivars in both cropping seasons. Bulb weight and number of cloves per bulb were highly significantly (P<0.01) influenced by cultivars in both cropping seasons. Also, marketable yield, unmarketable yield and total yield ha-1 were highly significantly (P<0.01) influenced by cultivars in both seasons. During 2017 and 2018, the highest marketable bulb yield was observed from Ofla Local cultivar with an average value of (8.86 t/ha) and (9.06 t/ha) respectively. During the 2017 cropping year, the maximum and significantly higher total bulb yield of 10.21 t/ha was recorded on the Ofla Local cultivar. Moreover, in 2018, this cultivar provided the maximum total bulb yield of 9.80 t/ha. Therefore, the Ofla Local cultivar showed the greatest performance for growth, yield and yield related attributes. Thus, it is recommended for cultivation in areas having similar agro-ecology. To improve the productivity of garlic, it is important to study and identify the optimum fertilizer level and spacing in the study area.
THE STATE ANALYSIS OF THE ANTI-EROSION INSTALLATIONS CARRIED OUT FOR THE PROTECTION OF THE CITY OF HASSI EL GHALA (WILAYA OF AIN TEMOUCHENT, ALGERIA) AGAINST FLOODS
Authors: ZEKRI Nadia , SID Ahmed Soufiane
Published: October 2023

Water erosion is an inevitable natural phenomenon that sometimes causes very serious damage to infrastructure (towns, roads, hydraulic dams, etc.). Things’ which require anti erosion restorations, in the watersheds of these infrastructures, to protect them. The objective of this research is to perform an is analysis of the state and effectiveness of some anti-erosion restorations, in particular of the thresholds of torrential correction, carried out since 1986 to protect the city of Hassi El Ghalla (region of Ain Temouchent) against floods. The methodology adopted was based on direct observations in the field, taking photos and collecting data at the level of forest conservation in the wilaya of Ain Témouchent. The results obtained revealed a positive assessment of the state of the anti-erosion facilities. The torrential correction weirs and the stepped terraces are mostly in good condition. The vegetation cover is quite dense and the soils are more vulnerable to sheet erosion, qualified as less dangerous compared to linear erosion and mass erosion. The implementation of anti-erosion actions has highly protected the town of Hassi El Ghala against flood. But the forest administration must bring some rehabilitations to these actions and maintain their in sustainability for more efficiency.
TÜRKİYE'DE YETİŞTİRİLEN ANA ARILARIN FİZİKSEL KALİTE KRİTERLERİ VE TÜRKİYE ARICILIĞI İÇİN ÖNEMİ
Authors: Cengiz Mahir Murat , Arslan Servet
Published: October 2023

Derleme, ana arıların fiziksel kalitesini etkileyen hayati parametreleri incelemektedir. Beslenme, çevre koşulları ve yetiştirme teknikleri gibi faktörlere odaklanan çalışma, bu kriterlerin bal arısı kolonilerinin genel sağlığı ve üretkenliği üzerindeki doğrudan etkisinin altını çiziyor. Gelişmiş koloni performansı ve hastalıklara karşı direnç sağlamak için sağlam ve genetik olarak çeşitli ana arıların seçilmesinin önemini vurgulamaktadır. Ticari işletmelerde yüksek kaliteli ana arıların benimsenmesini teşvik ederek, Türkiye'deki bal arısı popülasyonlarının canlılığını ve sürdürülebilirliğini artırmayı amaçlamaktadır. Bu çalışma sayesinde, Türk arıcılık endüstrisindeki arıcılar ve paydaşlar, ana arı üretiminde fiziksel kalite standartlarına bağlı kalmanın önemine dair önemli bilgiler edinmektedir. Arıcılar önerilen kriterleri uygulayarak bal üretimini artırabilir, tozlaşma hizmetlerini iyileştirebilir ve ülke florasının korunmasına katkıda bulunabilir. Sonuç olarak, bu çabalar Türkiye'de sağlam ve sürdürülebilir bir arıcılık sektörünün büyümesini destekleyecektir.
Establishment and Validation of Prognostic Model of Lung Adenocarcinoma Based on Apoptosis-Related Genes
Authors: Liu Yu
Published: October 2023

Objective: Apoptosis is an autonomous cell death process controlled by genes that can keep the internal environment of cells relatively stable. Lately, many studies have shown that apoptosis plays an important role in the construction of tumor microenvironment, mainly through the release of a series of regulatory factors to control cell growth. Therefore, it is very valuable to find and explore the possible role of apoptosis in the pathogenesis of lung cancer and its impact on the prognosis of patients. Materials and Methods: We selected 10 apoptosis-related genes and used different statistical methods to construct a model to predict the survival and prognosis of patients with lung adenocarcinoma. Univariate and multivariate Cox analysis were used to evaluate the predictive power and value of prognostic models, as well as receiver operating characteristic (ROC) curve analysis. Results: We defined two subgroups (cluster1 and cluster2). Compared with cluster1, cluster2 was named "apoptosis inhibition subgroup". The survival prognosis of cluster1 was significantly better than that of cluster2, and the infiltration of immune cells in cluster2 suggested that its immune system was inhibited. Then, we established a new prognostic model of apoptosis-related genes to identify high-risk patients with lung adenocarcinoma. Two types of Cox proportional hazards analysis and ROC curve showed that our model can be used as a new independent factor for the prognosis of lung adenocarcinoma patients, and had strong predictive ability. Conclusion: Apoptosis is involved in the formation and development of lung adenocarcinoma and plays an important role. Our survival model can better predict the survival and prognosis of lung adenocarcinoma, and our study may be helpful for further research on new therapeutic targets and precise individualized treatment in the future.
Unruptured Ovarian ectopic pregnancy in adolescence
Authors: Fan Yang
Published: October 2023

Ovarian pregnancy is one of the rarest types of ectopic pregnancy. Its preoperative diagnosis remains a challenge because of it presents quite similarly to tubal pregnancy and complicated ovarian cysts. In most cases, histology is necessary to confirm the diagnosis, we present an unruptured ovarian pregnancy in a teenager diagnosed during laparoscopy operation.
Antibiotic-Free Helicobacter Pylori Eradication – Case Reports and Review of The Literature
Authors: Bahadori Babak
Published: October 2023

Background: Standard Helicobacter pylori eradication therapy is based on proton pump inhibitors and antibiotics. There are, however, important limitations: increasing antibiotic resistance of Helicobacter pylori, medical contraindications, and an increasing unwillingness among patients to use antibiotics. Case presentations: We present three exemplary case reports of successful antibiotic-free Helicobacter pylori eradication therapies, one for each of these limiting categories: a 61-year-old female Caucasian patient refractory to prior eradication therapy, an 80-year-old female Caucasian patient with contraindication to antibiotics, and a 41-year-old male Caucasian patient refusing antibiotics. A review of the literature attempts to provide a scientific rationale for proton pump inhibitor-based and probiotics-supported Helicobacter pylori eradication. Conclusion: Antibiotics-free Helicobacter pylori eradication may offer a therapeutic option for patients in whom classical eradication therapy cannot be conducted or who are refractory to antibiotics. Clinical trials are needed to scientifically evaluate the concept presented here.
A Brief Review on Aloe Vera & Aloe Vera Gel
Authors: Kamil Mohammad
Published: October 2023

Aloe vera has a storied history of use. Mesopotamian clay tablets dated 1750 BC indicate that Aloe vera was being used for medicinal purposes. Egyptian records from 550 BC also mentioned aloe for infections of the skin. The ancient Greeks were also aware of aloe’s medicinal effects as both Pliny (23-79 AD) and Dioscorides (1st century AD) wrote of aloe’s ability to treat wounds and heal infections of the skin. Aloe vera is still widely used in many traditional systems of medicine.
Formulation and Evaluation of Aspirin Nanosuspension Using Probe Sonication Method
Authors: Sailaja A. Krishna
Published: October 2023

Aspirin inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever. Aspirin having various function like anti-inflammatory, analgesic, antipyretic etc. Aspirin loaded nanosuspension was prepared to enhance the bioavailability of the drug. Nanosuspension is defined as a finely dispersed solid particle dissolved in aqueous and organic medium for oral, tropical, parenteral or pulmonary administration. The size ranges about 200nm to 600nm.Aspirin loaded nanosuspension was prepared by probe sonication method. The probe sonication method is used to reduce the particle size and to increase the solubility of the drug. Total 5 Nano formulations were prepared in which NS1 shows 100% of drug content. Invitro Drug release was performed using Franz diffusion cell in which NS5 formulation shows 94.7% drug release in a time period of two hours and 30 minutes. Entrapment efficiency was performed using Ultracentrifugation method kept for 40 minutes at 17,000 rpm speed. Among all NS5 shows 71.9% of entrapment efficiency.
Intracranial Hypotension and Bilateral Isolated Cortical Vein Thrombosis: A Case Report and Literature Review
Authors: Filippaios Andreas
Published: October 2023

Background: Intracranial hypotension (IH) is a clinical manifestation of low cerebrospinal fluid pressure with reports of isolated cortical venous thrombosis (ICVT) rarely described. Case Presentation: A 23-year-old man presented with postural headache followed by blurry vision and horizontal binocular diplopia with extreme gaze. Patient workup showed diffuse thickening and enhancement of the dura suggestive of intracranial hypotension and biparietal superficial cortical vein thrombosis was noted on imaging. The patient was started on folate and therapeutic anticoagulation and his condition improved. Conclusion: Patients with IH are at risk for CVT due to the dilation of the venous sinuses of the brain. Changes in the characteristics of the headache of the patient or the onset of new neurological symptoms should warrant further investigation. Prophylactic systemic anticoagulation might cautiously be indicated in high-risk patients with IH to prevent ICVT.
Gold-Induced Cytokine (Goldic®) – A Promising Treatment in Patients with Grade 4 Knee Osteoarthritis: A Case Study
Authors: Pithadia Pooja
Published: October 2023

Background: Knee osteoarthritis (KOA) is one of the most common degenerative diseases that can lead to disability and pain. The degenerative nature of this condition cannot be reversed or healed by any currently available treatments. Recently, there has been an upcoming interest in treating degenerative tissue disorders with minimally invasive autologous blood products. Autologous blood was preconditioned with gold particles to encourage the production of various proteins in patients’ blood. This current study investigated the safety and efficacy of pre-conditioning autologous blood with gold particles (GOLDIC®) in patients with severe knee osteoarthritis (KOA). Case presentation We report a case in which four intra-articular GOLDIC® injections were used to treat knee osteoarthritis. After a week, physiotherapy was recommended. Before and three weeks after the injections, she was assessed for her weight, the Visual Analog Scale (VAS), and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score. GOLDIC® treatment resulted in significant weight, VAS, and WOMAC score improvements without serious side effects. Conclusion Due to the one-time blood harvesting and only four injections, the initial results demonstrated that the treatment plan is safe, less expensive, patient-friendly, and more successful at achieving compliance. This GOLDIC® treatment can significantly decrease pain and improve knee capability with overall satisfaction over a significant period. To fully validate the real potential of GOLDIC® in heterogeneous patient populations and to compare these promising results to other blood-based platforms, future randomized-controlled trials with long-term follow-up are required, despite the promising early clinical results.
Archaeobotanical research results from cultural layer of the posad of Beryozov in the 17th-18th centuries
Authors:   Institute of Plant and Animal Ecology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Lapteva Elena G. ,   Scientific and Educational Centre of the Institute for Humanities Education and Sport, Surgut State University, Surgut, Korona Olga M. ,   Institute of Plant and Animal Ecology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Lobanova Tatyana V. ,   Institute of Plant and Animal Ecology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg,   Scientific and Educational Centre of the Institute for Humanities Education and Sport, Surgut State University, Surgut, Vizgalov Georgiy P. ,   Scientific and Educational Centre of the Institute for Humanities Education and Sport, Surgut State University, Surgut,   Institute of Archaeology and Ethnography of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk,   “Scientific Production Association “Northern Archaeology – 1” LLC, Nefteyugansk
Published: October 2023

В статье приведены результаты археоботанического изучения образцов из г. Берёзова. Были исследованы микро- и макроостатки местной флоры и растений, привезенных из южных земледельческих районов Западной Сибири, – овса и хмеля. Выяснилось, что вместе с зерновыми были завезены семена и плоды разнообразных сорных растений. Установлено, что все разнообразие растительных ресурсов окрестностей жители использовали как строительный материал, включали в свой пищевой рацион и в кормовую базу для домашних животных.
About the traditional architecture of the lower ob region of the 15th-19th centuries (based on the materials of archaeological and historical-architectural research)
Authors:   Center of Ugor Archaeology and Ethnography, Surgut State University, Surgut, Kardash Oleg V. ,   Institute of Archaeology and Ethnography of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk,   ANO “Institute of  Archeology of the North”, Nefteyugansk, Alekseeva Ekaterina A. ,   ANO “Institute of  Archeology of the North”, Nefteyugansk, Palyanova Maria N. ,   ANO “Institute of Archaeology of the North”, Nefteyugansk,   MBU TO “CDO “Search”, Nefteyugansk
Published: October 2023

В статье приведен анализ архитектурно-строительной традиции аборигенного населения Нижнего Приобья, позволивший заключить, что домостроительный прием строительства из досок «в охряпку со сжимами на обоймах», который применялся у аборигенного населения с XVI до первой трети XVIII в., не имеет аналогов в других регионах России. Он распространен только на территории Нижнего Приобья, на близлежащих территориях р. Таз и в верховьях р. Вишеры. А единственным обнаруженным аналогом в мире являются конструкции альпийских швейцарских дощатых построек.
Documentary sources of the 18th century on the composition of the population of the Nadym town: the experience of calculating the number of inhabitants
Authors:   Scientific and Educational Centre of the Institute for Humanities Education and Sport, Surgut State University, Surgut, Kardash Oleg V. ,   Institute of Archaeology and Ethnography of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk,   ANO “Institute of  Archeology of the North”, Nefteyugansk, Slesarenko Inna V. ,   ANO “Institute of Archaeology of the North”, Nefteyugansk., Ermakova Kseniya K. ,   ANO “Institute of Archaeology of the North”, Nefteyugansk
Published: October 2023

В статье дан опыт расчета численности населения древних поселений и попытка создания базовой модели для ее расчета. Алгоритм моделируется на примере комплексно изученного памятника – раннего Надымского городка. Для верификации письменных источников используются данные археологических исследований. Модель расчета апробирована на позднем Надымском городке с использованием не публиковавшихся ранее документов – ревизских сказок XVIII–XIX вв.
Прояви колабораціонізму на Поділлі в роки нацистської окупації краю
Authors: Гальчак Сергій
Published: October 2023

The article examines the reasons and signs of collaborationism in Podillya during the Second World War. It considers the cooperation of the Ukrainian subsidiary administration and police with the occupation regime after their transition under the full control of German civil administration as well as the signs of collaborationism on the part of Vlasov army departments and Russian Cossack formations.
Pengaruh Budaya Organisasi Dan Kepuasan Kerja Dalam Meningkatkan Kinerja Pegawai Yayasan Mutiara Titipan Illahi
Authors: Lukman Nulmunir  , Suryanto  , Dadang Dally
Published: October 2023

Sejalan dengan perkembangan dunia usaha yang semakin global, pengelolaan suatu organisasi harus dilakukan secara profesional dan produktif sehingga organisasi dapat mencapai tujuan. Kondisi ini akan hadir ketika terdapat kinerja yang baik dari karyawannya. Penelitian ini bertujuan untuk mengetahui bagaimana budaya organisasi dan kepuasan kerja dapat mempengaruhi terhadap kinerja karyawan yang ada pada Yayasan Mutiara Titipan Illahi. Penelitian ini dilakukan dengan menggunakan pendekatan kuantitatif, dengan populasi penelitian seluruh pegawai yang ada pada Yayasan Mutiara Titipan Illahi yang terdiri dari 13 cabang dengan jumlah sampel yaitu populasi itu sendiri sebanyak 62 pegawai. Pengumpulan data dilakukan dengan metode survei dengan menyebarkan kuesioner kepada responden. Data dianalisis lebih lanjut menggunakan pendekatan analisis regresi berganda dengan bantuan software SPSS 26 for Windows. Hasil penelitian ini menunjukkan jika budaya organisasi dan kepuasan kerja berpengaruh positif terhadap kinerja karyawan Yayasan Mutiara Titipan Illahi.
PROBLEMS OF INFORMATION AND ANALYTICAL PROVISION OF BUSINESS ACTIVITIES UNSHADOWING IN UKRAINE
Authors: DYMCHENKO Olena , SMACHYLO Valentyna , TARARUIEV Iurii ,   O. M. Beketov National University of Urban Economy
Published: October 2023

According to the results of the systematization and analysis of the problems of information and analytical support of the of business activity unshadowing in Ukraine, it was determined that these problems are interconnected, and ignoring them significantly complicates the unshadowing process. It was found out that the peculiarities of shadow activity require the state to create proper conditions for the voluntary exit of entrepreneurs from the shadow sector of the economy. At the same time, the legalization of activity should be beneficial for entrepreneurs. The article emphasizes that the change in the status of entrepreneurs should be properly recorded by state bodies, which will lead to the accumulation of primary information and allow determining the success criteria of unshadowing, the ratios for the calculation of which are given above. To simplify the analysis, the indicator of tax revenues per legalized business entity is presented in the form of a two-factor multiplicative model, which will allow provide factor analysis of unshadowing processes and improve the given model by adding factor indicators. The final result of the article is the formulation of the stages of information and analytical support for the unshadowing of entrepreneurial activity. Prospective areas of research into the problems of information and analytical support for the unshadowing of entrepreneurial activity include: substantiation of practical proposals for motivating entrepreneurs to exit the shadow sector of the economy through the use of tax discounts, debt restructuring, etc.; clarification of the list of indicators that can be considered criteria for the success of entrepreneurial activity unshadowing; application of mathematical methods to substantiate hypotheses regarding the size and changes of the shadow sector of the economy of Ukraine.
PENGARUH SALES PROMOTION APLIKASI TIKTOK, ONLINE COSTUMER REVIEW DAN HARGA TERHADAP KEPUTUSAN PEMBELIAN PADA PENGGUNA TOKOPEDIA
Authors: Maghfirotul Hasanah Fadila , Priantilianingtiasari Ruly
Published: October 2023

Current technological developments have made a shift in behavior in consuming a product from offline to online, this is marked by the development of e-commerce which has increased significantly Increasing online sales requires several things, one of which is sales promotion for the TikTok application, online customer reviews, and prices which have recently received attention from the business community and academics in relation to purchasing decisions. This study aims to determine the effect of the TikTok application sales promotion on purchasing decisions, the effect of online customer reviews on purchasing decisions, the effect of price on purchasing decisions and to determine the effect of TikTok application sales promotion, online customer reviews and prices simultaneously on purchasing decisions. The approach used is associative quantitative research, with Tokopedia and TikTok users as the population, with the number of Fakultas Ekonomi dan Bisnis Islam 2021 students at Universitas Islam Negri Sayyid Ali Rahmatullah Tulungagung of 3.537 students who are the population in this study, using the Slovin formula as the basis for taking the number of samples, namely 392 using the probability sampling technique and data collection using a questionnaire with a Likert measurement scale. The data were processed using SPSS version 22 through multiple linear regression. With the results of the TikTok application sales promotion research that has a significant effect on purchasing decisions, online customer reviews have a significant effect on purchasing decisions, prices have a significant effect on purchasing decisions and simultaneously TikTok application sales promotion, online customer reviews and prices have a significant effect on purchasing decisions.
ANALISIS RISIKO PROFIL DAN PENGARUHNYA TERHADAP PROFITABILITAS PADA BANK BUMN
Authors: Ambardi Ambardi , Alim Mulia , Aminah Aam , Helmi Helmi
Published: October 2023

The purpose of this study is to analyze the risk profile and its impact on profitability at state-owned banks. The sampling technique used in this study is Nonprobability Sampling, namely Purposive Sampling. The population and samples used in this study are state-owned banks, namely Bank BNI, Bank Mandiri, Bank BRI, and Bank BTN by taking data from annual financial reports published from 2017 to 2022. The data analysis technique used is descriptive statistical analysis and statistical analysis. statistics. Descriptive statistical analysis was used to describe the variables in this study, namely Non Performing Loans (NPL), Loan to Deposit Ratio (LDR) and Return on Assets (ROA). The statistical analysis used was multiple linear regression panel data tests which were first tested for model selection, then added the classic assumption test as a condition for using regression analysis. Furthermore, F statistical tests and t statistical tests (hypothesis testing) were carried out, the coefficient of determination. The results of this study are that NPL or non-performing loans have no significant negative effect on ROA at state-owned banks. From the NPL value, it can also be concluded that 3 state-owned banks, namely BNI, Mandiri and BRI, have relatively good NPL levels, meaning that the risk of bad credit is low, except for BTN banks. As for the LDR or Loan to Deposit Ratio, there is no significant effect on ROA at government banks.
ANALISIS TINGKAT DISIPLIN KERJA KARYAWAN PADA TOKO SENJA KOSMETIK
Authors: Suroso Suroso , Tsania Syita , Karnama Maman Mulya
Published: October 2023

The purpose of this study was to determine the Compliance Level of Employee Discipline at Senja Cosmetics Shop and the factors that cause violations of employee work discipline. The research method used in this work uses a qualitative descriptive method. With this approach, the researcher wants to conduct research in a natural setting or following the existing context. The researcher leads according to the facts related to the Analysis of Employee Discipline Compliance Level at the Senja Cosmetics Shop. The results of the study show that the enforcement of work discipline at the Senja Cosmetics Shop is still said to be not good because there is no supervision of employees at the Senja Cosmetics Shop so there are still some employees who are undisciplined and the factors that cause violations of employee work discipline because there is no application of applicable sanctions and no definite rules or enforcement of written rules that can be used as a guide by employees at the Senja Cosmetics Shop. Leaders should need to supervise and take strict disciplinary action against employees so that employees can further improve their discipline.
PENGAKUAN PENDAPATAN DAN BEBAN PADA PT. IMM SAAT MASA PANDEMI 2020-2021
Authors: Puteh Rio Nanda , Sahusilawane Wildoms
Published: October 2023

COVID-19 has a broad impact on the Indonesian economy. One is in the automotive sector, which suffers negative consequences such as inhibiting production processes due to social constraints that lead to a shortage of auto components and rising sales prices. Vulnerable market conditions make rising component prices a serious problem that must be addressed with good planning in order to avoid prolonged losses. In the mitodst of an unstable economy, recognition of income and burden becomes very important and crucial. The company’s policy plays a decisive role in recognising accrual profits and accrual burdens, affecting the financial statements, especially the company's profit and loss report. This study aims to explain and analyse the recognition of PT's income and burden. IMM during the early pandemic period in 2020 and compared it to 2021. The research uses a descriptive qualitative approach with data collection techniques through interviews, observations, and analysis of PT financial statements. by IMM. To improve the validity of the research, the triangulation technique of the source is used in the financial statements for 2020 and 2021 PT by IMM. The results of this study showed that PT. IMM records the recognition of revenue and expenses based on referring to PSAK rather than SAK ETAP, and is recognized using the accrual basis method where the financial statements in 2021 demonstrate an increase and better compared to the year 2020.
ANALISIS RASIO KEUANGAN DAN FINANCIAL DISTRESS SEBELUM DAN SESUDAH COVID-19 SUBSECTOR FOOD AND BEVERAGE
Authors: Putri Dinda Ramadhani , Azis Azolla Degita , Rizqi Muhammad Nur
Published: October 2023

after, and during the covid 19 pandemic. The sample taken was purposive sampling in food and beverage subsector manufacturing industry companies listed on the Indonesia Stock Exchange for the period 2018-2021. The data analysis method used is the difference test or the Anova analysis method. Where the results showed CR, ROA, DAR, and TATO there was a difference in financial distress every period of the year, except in 2021 CR there was no significant difference in FD. It is hoped that the results of this study can be a benchmark in determining policies to avoid financial distress.Keywords: financial distress, financial ratio, Altman z-score