bluuebunny/crossref_metadata_2025 huggingface dataset:
Combination therapy for mCRPC with immune checkpoint inhibitors, ADT and vaccine: A mathematical model
Authors: Siewe Nourridine , Friedman Avner
Published: January 2022

Metastatic castration resistant prostate cancer (mCRPC) is commonly treated by androgen deprivation therapy (ADT) in combination with chemotherapy. Immune therapy by checkpoint inhibitors, has become a powerful new tool in the treatment of melanoma and lung cancer, and it is currently being used in clinical trials in other cancers, including mCRPC. However, so far, clinical trials with PD-1 and CTLA-4 inhibitors have been disappointing. In the present paper we develop a mathematical model to assess the efficacy of any combination of ADT with cancer vaccine, PD-1 inhibitor, and CTLA-4 inhibitor. The model is represented by a system of partial differential equations (PDEs) for cells, cytokines and drugs whose density/concentration evolves in time within the tumor. Efficacy of treatment is determined by the reduction in tumor volume at the endpoint of treatment. In mice experiments with ADT and various combinations of PD-1 and CTLA-4 inhibitors, tumor volume at day 30 was always larger than the initial tumor. Our model, however, shows that we can decrease tumor volume with large enough dose; for example, with 10 fold increase in the dose of anti-PD-1, initial tumor volume will decrease by 60%. Although the treatment with ADT in combination with PD-1 inhibitor or CTLA-4 inhibitor has been disappointing in clinical trials, our simulations suggest that, disregarding negative effects, combinations of ADT with checkpoint inhibitors can be effective in reducing tumor volume if larger doses are used. This points to the need for determining the optimal combination and amounts of dose for individual patients.
Temas de história contemporânea
Authors: Amaro António Rafael , Garrido Álvaro , Nunes João Paulo Avelãs
Published: January 2022

O presente livro versa temáticas e regionalidades históricas muito diversas, na sua maioria referentes a temas portugueses, participando todos eles do conceito abrangente de História Contemporânea, inscrevendo-se nos séculos XIX e XX.
Na sua polissemia intrínseca, o conceito de História Contemporânea remete para o discurso histórico que os historiadores produzem e difundem sobre o tempo recente dentro e fora do espaço académico. Nos dias que correm, a História Contemporânea debate-se com outras formas de memória social e disputa as suas versões do passado com diversos dispositivos de mediação entre presente e passado. Se “toda a História é contemporânea”, aquela que versa sobre o passado que vivemos ou que nos é próximo debate-se ainda mais com a pluralidade das narrativas e com o desafio da recordação.
Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer
Authors: Jo Won Il , Lim Dae Ro , Kuk Jung Cheol , Shin Eung Jin
Published: January 2022

Purpose: The present study compares the peri/postoperative and oncological outcomes of abdominoperineal resections (APR) and sphincter saving resection (SSR) for low lying rectal cancer.Methods: Between January 2001 and December 2014, 176 patients who underwent SSR (n = 67) and APR (n = 109) for low rectal cancer, without stage IV, were retrieved from a retrospective database.Results: With a median follow-up of 66.5 months. The mean total number of harvested lymph nodes was 16.7 (SSR) versus 17.1 (APR) (P = 0.801). The advanced T stage was higher in the APR group (82.6%) versus the SSR group (55.2%) (P = 0.006). The positive rate of lymph nodes after surgery was significantly higher in the APR group (45.9%) versus SSR group (25.4%) (P < 0.05). The 5-year overall survival rates for SSR and APR were 87.3% and 67.6%, respectively (P < 0.005). The 5-year disease-free survival rate (DFS) was 83.6% (SSR) versus 65.5% (APR) (P = 0.002). The recurrence rate was higher in the APR group (34.9%) versus the SSR group (14.9%) (P = 0.004). Local recurrence rate was not different between the two groups. However, distant recurrence rate was significantly higher in the APR group (26.6% vs. 11.9%, P = 0.023). In multivariate analysis, node positive (N0 vs. N1-2) was an independent prognostic factor for DFS (P < 0.005).Conclusion: Based on the present data, SSR achieved better 5-year oncological outcome than APR. The positive lymph node ratio in the N stage after surgery was higher in the APR group and this seems to have an effect on the oncological outcomes of the APR group.
PERCEPTION OF INSTITUTIONALIZED ELDERLY ABOUT QUALITY OF LIFE: AN INTEGRATIVE REVIEW
Authors: Luna Cícera Alves de , Sousa Allex Alves Sobral de , Queiroz Iasmim Belém Silva , Sampaio Samyra Maria Lima , Gurgel Lucineide Coqueiro , Luna Thayná Bezerra de , Sousa Carmelita Maria Silva , Cordeiro Abigail de Almeida , Luz Dayse Christina Rodrigues Pereira , Santana Willma José de
Published: January 2022

Abstract: Aging is a physiological process that happens over time permeated by biological, psychosocial and cultural changes. Through the increase in life expectancy and, consequently, population aging worldwide, the Long Term Care Institutions for the Elderly (ILPI) stand out in caring for these elderly people, making it necessary to know what life is like for the elderly in this environment. Given the above, the study aimed to verify in the literature the perspective of institutionalized elderly about quality of life. Thus, the study is an integrative literature review with a qualitative approach, using Lilacs, Scielo and Medline databases as a means of research, taking advantage of the following Health Sciences Descriptors (DeCS): “Elderly”, “Quality of life” and “institutionalized”. The study sample consisted of 16 articles, which discussed the theme of the study, in which it was sought to verify the perception of institutionalized elderly about quality of life, it was decided to carry out two thematic categories: 01) Quality of Life for the Elderly Institutionalized, and 02) Perception of the Institutionalized Elderly. In view of the above, the study was able to show that the elderly who reside, live in a Long-Term Care Facility for the Elderly (ILPI), it is necessary to be active, dynamic, prepared to carry out their activities of daily living, in order to achieve their quality of life, harmonize health and promote healthy aging. Keywords: Elderly, Quality of Life, Institutionalized.
Perfil da população cadastrada em uma Unidade Básica de Saúde da Família: a importância da classificação de risco familiar
Authors: Borges Sandy , Santiago Fernanda de Jesus , Silva Luciana Saraiva da
Published: January 2022

A Atenção Básica (AB) é considerada o primeiro nível de atenção em saúde e tem na Saúde da Família sua estratégia prioritária para expansão e consolidação. O objetivo do estudo foi descrever o perfil e a classificação de risco familiar dos usuários de uma Unidade Básica de Saúde da Família em Uberlândia, Minas Gerais. Trata-se de um estudo transversal, com dados coletados dos Sistemas de Informações, nos anos 2017 e 2018. Foram analisadas variáveis sociodemográficas, classificação dos grupos populacionais e risco familiar. Para a classificação de risco familiar foram considerados fatores socioeconômicos (grau de alfabetização do chefe da família, renda e abastecimento de água) e fatores clínicos (grau de risco dos seguintes grupos/condições: gestante, criança, hipertensão, diabetes, doença renal crônica ou outras condições crônicas de alto risco). Foram avaliados 1553 usuários, sendo 70,6% do sexo feminino. A faixa etária predominante foi entre 40 e 59 anos (33,23%) e a menos atendida foi a de adolescentes entre 14 e 17 anos (1,55%). Em relação à classificação de risco, observou-se maiores prevalências de hipertensão com médio risco, diabetes de alto risco e tuberculose de baixo risco. O estudo evidencia a importância do fortalecimento de políticas públicas, que visem à promoção e monitoramento das condições de saúde na AB.
Palavras-chave: atenção básica, fator de risco, doença crônica.
 
Abstract
Primary Health Care (PHC) is considered the first level of health care and has in Family Health its priority strategy for expansion and consolidation. The objective of the study was to describe the profile and family risk classification of users of the Family Health Unit in Uberlândia, Minas Gerais. This is a cross-sectional study, with data collected from the municipality's Information Systems, during the years 2017 and 2018. Sociodemographic variables, classification of population groups and family risk were analyzed. For the classification of family risk, socioeconomic factors (degree of literacy of the head of the household, income and water supply) and clinical factors (degree of risk of the following groups/conditions: pregnant woman, child, hypertension, diabetes, chronic kidney disease or other high-risk conditions). A total of 1553 users were evaluated, 70.6% of whom were female. The predominant age group was that of adults between 40 and 59 years old (33.23%) and the least attended was that of adolescents between 14 and 17 years old (1.55%). Regarding the risk classification, there was a higher prevalence of medium-risk hypertension, high-risk diabetes and low-risk tuberculosis. The study highlights the importance of strengthening public policies, aimed at promoting and monitoring health conditions in PHC.
Keywords: primary health care, risk factors, chronic disease.
Caracterização e perfil do desenvolvimento de crianças em puericultura de uma Estratégia de Saúde da Família
Authors: Bombarda Müller Alessandra , Consi Bibiana Mafaldo
Published: January 2022

Resumo
Objetivo: identificar o perfil de desenvolvimento de crianças assistidas em consultas de puericultura de uma Estratégia de Saúde da Família e os fatores que influenciam esse desenvolvimento.
Método: pesquisa observacional, prospectiva, descritiva, do tipo transversal, com entrevistas semiestruturadas sobre questões socioeconômicas e ambientais. O instrumento de avaliação do desenvolvimento infantil foi o Survey of Well-being of Young Children (SWYC).
Resultados: 26 crianças entre dois e 19 meses participaram do estudo, com maior prevalência do sexo feminino (57,7%). A maioria das crianças da amostra não frequentava creche (88,5%). Na avaliação dos marcos do desenvolvimento infantil, foi observado comportamento motor adequado para a faixa etária avaliada, entretanto, resultados abaixo da média foram encontrados especificamente na área da linguagem.
Conclusão: estes resultados poderão contribuir para o planejamento de ações específicas para as demandas desta população na unidade de saúde, e, por consequência, melhorar as condições de saúde destas crianças e suas famílias.
Palavras-chave: Desenvolvimento Infantil, Perfil de Saúde, Atenção Primária à Saúde, Fisioterapia, Diagnóstico da Situação de Saúde.
Médicos de Família e Comunidade ou médicos da Estratégia Saúde da Família? / Family and Community doctors, or doctors from the Family Health strategy?
Authors: Fontenelle Leonardo Ferreira
Published: January 2022

Em resposta à revisão integrativa “Papel do Médico de Família e Comunidade no Manejo da Hipertensão Arterial na Atenção Primaria à Saúde”, cumpre destacar que os médicos de família e comunidade constituem uma especialidade médica, enquanto os médicos da estratégia Saúde da Família constituem uma ocupação. Discute-se a não sobreposição entre as duas categorias no mercado de trabalho, e a distinção no que diz respeito ao escopo da prática, com ênfase na saúde mental.---Abstract: In response to the integrative review “Role of the Family and Community Doctor in theManagement of Hypertension in Primary Health Care”, it should be noted that family and communitydoctors are a medical specialty, while doctors of the Family Health strategy constitute an occupation. Itdiscusses the non-overlapping between the two categories in the labor market, and the distinctionregarding the scope of practice, with an emphasis on mental health.
Bruxismo Infantil: Uma Revisão de Literatura / Children's Bruxism: A Literature Review
Authors: Neves Adrielle Barbosa , Freire Carla De Oliveira , Pinchemel Edite Novais Borges
Published: January 2022

Resumo: O objetivo do presente estudo foi discutir aspectos do bruxismo infantil através de uma revisão de literatura, abordando os fatores etiológicos bem como sinais, sintomas e características clínicas desta condição. É de grande importância o domínio dos sinais e sintomas para um diagnóstico mais preciso pelos profissionais da odontopediatria.  O  tratamento é multidisciplinar para esta condição parafuncional. Os resultados demonstraram ser o bruxismo um hábito não funcional da função mastigatória, que se caracteriza , pelo  ato de apertar ou ranger os dentes, ocorrendo tanto durante o dia como no momento do sono. A etiologia é multifatorial e a literatura apresenta diversos, tais como fatores associados: dentário, fisiológico,  psicológico e neurológico. O sinal mais comum é um certo desgaste nas  faces incisais, principalmente dos dentes anteriores e, oclusais nos dentes posteriores. Também tende a ocasionar hipersensibilidade dentária, fratura  de cúspides e restaurações e hipertonicidade dos músculos  mastigatórios.  Concluiu-se que conhecer os fatores etiológicos e as  características clínicas do bruxismo na infância é importante para um diagnóstico o mais  rápido possível, permitindo um tratamento precoce que favoreça o bem-estar da criança. Palavras-chave: bruxismo; crianças; odontopediatria.  Abstract: The aim of this study was to discuss aspects of childhood bruxism through a literature review, addressing the etiological factors as well as signs, symptoms and clinical characteristics of this condition. It is very important to master the signs and symptoms for a more accurate diagnosis by pediatric dentistry professionals. Treatment is multidisciplinary for this parafunctional condition. The results showed that bruxism is a non-functional habit of the masticatory function, which is characterized by the act of squeezing or grinding the teeth, occurring both during the day and during sleep. The etiology is multifactorial and the literature presents several, such as associated factors: dental, physiological, psychological and neurological. The most common sign is some wear on the incisal surfaces, especially on the anterior teeth, and occlusal on the posterior teeth. It also tends to cause tooth hypersensitivity, fracture of the cusps and restorations, and hypertonicity of masticatory muscles. It was concluded that knowing the etiological factors and clinical characteristics of bruxism in childhood is important for a diagnosis as quickly as possible, allowing an early treatment that favors the child's well-being.Keywords: bruxism; kids; pediatric dentistry.
A Ludicidade como Instrumento de Incentivo e Aprendizagem na Modalidade EJA - Ensino de Jovens e Adultos / Ludicity as an Incentive and Learning Instrument in the EJA Modality - Youth and Adults Education
Authors: Fagundes Paula Wanessa Alves , Menezes Aurelania Maria de Carvalho
Published: January 2022

Resumo: Este artigo tem como principal objetivo apresentar ao leitor uma nova perspectiva de ensino na modalidade EJA mediante as atribuições da ludicidade. O termo ludicidade remete muito ao ambiente infantil, que é mais proveniente de brincadeiras e jogos direcionados em seu contexto, mas na EJA vem abrindo espaço para o novo, com novas estratégias lúdicas para ampliação do conhecimento. O estudo dispõe como bases teóricas estudos bibliográficos de caráter qualitativo que foi o processo metodológico utilizado para a construção do artigo, assim como análise em obras e falas de autores renomados no tema abordado que tem opiniões formadas sobre o aspecto lúdico como mecanismo de aprendizagem. Foram apontadas algumas sugestões de procedimentos lúdicos a alunos de EJA, assim como uma perspectiva atendida na construção para educadores flexivos e inovadores.Abstract:This article has as main objective to present to the reader a new perspective of teaching in the EJA modality through the attributions of playfulness. The term playfulness refers a lot to the children's environment, which comes more from games and games directed in its context, but in EJA it has been opening space for the new, with new playful strategies to expand knowledge. The study has as theoretical bases bibliographic studies of a qualitative character, which was the methodological process used to build the article, as well as analysis in works and speeches by renowned authors on the topic discussed who have formed opinions on the playful aspect as a learning mechanism. Some suggestions of playful procedures for EJA students were pointed out, as well as a perspective considered in the construction for flexible and innovative educators. Keywords: Playfulness, EJA, Learning, Incentive.
Inclusão de Crianças com Paralisia Cerebral nos Anos Iniciais do Ensino Fundamental / Inclusion of Children with Cerebral Palsy in the Early Years of Elementary School
Authors: Nascimento Michele Vivia Da Silva , Teixeira Verônica
Published: January 2022

Resumo: Esse trabalho irá mencionar assuntos bastante relevante, e que faz parte do nosso dia a dia em quando profissional da educação, como também formadores de cidadãos, falar de inclusão não é fácil, e principalmente colocá-la em prática. Mas é de suma importância, pois a educação é um direito de todos, e dever do Estado assegurar esse direito as crianças, jovens e adolescentes. Incluir ou inserir crianças diagnosticadas com Paralisia Cerebral no ambiente educacional é uma tarefa, um pouco complicada, pois requer um olhar diferenciado. Com isso, a escola precisa da ajuda da família nesse processo, como também da contribuição da comunidade em geral, pra trazer essas crianças pra esse ambiente, e assim desperta o conhecimento e as habilidades delas em questão cognitivo, emocional e afetivo, como também, o social. A visão que esse trabalho trará em seus pontos fundamentais e essenciais, na construção do saber e do fazer, uma educação inclusiva e acessiva de todos para todos; cabe os órgãos garantir formações específicas aos profissionais de educação, como os de apoios de sala de aula, sendo que, essas formações têm que abordar temas ligados a realidade do aluno que foram diagnosticados com tal deficiência.Palavras-Chave: Inclusão, Habilidades, Família, Direitos Deficiência Paralisia Cerebral. Abstract: This work will mention very relevant issues, which are part of our daily lives as education professionals, as well as citizen educators, talking about inclusion is not easy, and especially putting it into practice. But it is of paramount importance, as education is a right for all, and the State’s duty to ensure this right for children, young people and adolescents. Including or inserting children diagnosed with Cerebral Palsy in the educational environment is a task, a little complicated, as it requires a different look. With this, the school needs the help of the family in this process, as well as the contribution of the community in general, to bring these children to this environment, and thus awaken their knowledge and skills in cognitive, emotional and affective matters, as well as, the social. The vision that this work will bring in its fundamental and essential points, in the construction of knowledge and action, na inclusive and accessible education from all to all; it is up to the bodies to guarantee specific training for education professionals, such as classroom support, and these trainings have to address issues related to the reality of the student who has been diagnosed with such a disability.Keywords: Inclusion, Skills, Family, Rights Disability Cerebral Palsy.
Horta Comunitária e Quintais Produtivos da Comunidade Coelho Atikum Jurema e os Desafios da Covid-19 / Community Garden and Productive Backyards of the Coelho Atikum Jurema Community and the Challenges of Covid-19
Authors: Beserra Elijalma Augusto , Santos Vivianni Marques Leite dos , Silva Eva Mônica Sarmento da , Oliveira Lucia Marisy Souza Ribeiro de , Caffé Filho Hesler Piedade
Published: January 2022

A pandemia de Covid-19 gerou grandes mudanças na forma de comercializar os produtos da agricultura familiar. Foram dois anos de perdas e incertezas, mas também de redefinição das formas de produção e comercialização dos produtos da agricultura familiar. Neste contexto encontra-se a Comunidade Coelho Atikum Jurema, que, após anos de luta, implantou um projeto de horta comunitária e quintais produtivos. Neste espaço os agricultores familiares passaram a cultivar, de forma orgânica, e baseado na agricultura Atikum, espécies de olerícolas, mediante uma gestão coletiva e parental. Com o objetivo de identificar como a horta comunitária foi afetada pela Covid-19, realizou-se uma pesquisa descritiva, qualiquantitativa, no período de setembro a dezembro de 2021, onde foi possível identificar uma série de adversidades enfrentadas pela comunidade em adaptar-se ao mercado que surgiu como consequência das regras de convívio social, impostas em decorrência da Covid-19, as quais impactaram diretamente nas técnicas mercadológicas empregadas pela comunidade.---The Covid-19 pandemic generated major changes in the way in which family farming products are sold. There were two years of losses and uncertainties, but also of redefining the ways of production and marketing of family farm products. In this context is the Coelho Atikum Jurema Community, which, after years of struggle, implemented a project for a community garden and productive backyards. In this space, family farmers started to cultivate, organically, and based on Atikum agriculture, vegetable species, through collective and parental management. In order to identify how the community garden was affected by Covid-19, a descriptive, qualitative and quantitative research was carried out from September to December 2021, where it was possible to identify a series of adversities faced by the community in adapting to the market that emerged as a result of the rules of social interaction, imposed as a result of Covid-19, which directly impacted the marketing techniques used by the community.
Função Sexual de Mulheres com Vaginismo: Uma Revisão Integrativa da Literatura / Sexual Function of Women with Vaginismus: An Integrative Literature Review
Authors: Pardini Juliana Malta Pardini Malta , Azevedo Yasmine Domingues Silveira de , Ferreira Juliana Barros
Published: January 2022

O objetivo do artigo consiste em analisar a função sexual e a qualidade de vida de mulheres com vaginismo através da elaboração de uma revisão integrativa de literatura. O processo de elaboração fundamentou-se através da busca por artigos mediante das principais plataformas de periódicos em ciências e saúde mundial: Lilac’s, Medline e Scielo Os filtros aplicados consistiram no ano de publicação, entre 2018 a 2021, com conteúdo integralmente disponível nas línguas português, inglês e espanhol os critérios de inclusão estabeleceu-se estudos transversais. A partir dos filtros aplicados e através do processo de seleção de estudo, foram identificados 7 artigos científicos. É possível concluir que o vaginismo exerce forte impacto sobre a vida das pacientes diagnosticadas, tendo em vista que em algumas vezes o vaginismo, está associado a infertilidade, assim como a dor durante a relação sexual é intensa, comprometendo a satisfação, a qualidade e a prática do mesmo.---The aim of this article is to analyze the sexual function and quality of life of women with vaginismus through the development of an integrative literature review. The elaboration process was based on the search for articles through the main platforms of journals in science and health worldwide: Lilac's, Medline and Scielo. The filters applied consisted of the year of publication, between 2018 and 2021, with content fully available in Portuguese. , English and Spanish the inclusion criteria were established cross-sectional studies. From the filters applied and through the study selection process, 7 scientific articles were identified. It is possible to conclude that vaginismus has a strong impact on the lives of diagnosed patients, considering that sometimes vaginismus is associated with infertility, just as pain during sexual intercourse is intense, compromising satisfaction, quality and practice of it.Keywords: Sexual function; Vaginismus; Integrative review.
A Importância do Lúdico no Processo de Ensino Aprendizagem e no Desenvolvimento Infantil / The Importance of Playfulness in the Teaching-Learning and in Child Development
Authors: Santos Thayná Da Silva , Menezes Aurelania Maria De Carvalho
Published: January 2022

Resumo: O presente trabalho tem como intuito investigar sobre a importância do lúdico no processo de ensino aprendizagem e no desenvolvimento da criança, esta análise se justifica por conjecturar que a ludicidade tem grande influência no processo de evolução infantil, pois é mediante o brincar que a criança amplifica seus sentidos, e propicia uma melhor forma de se expressar. Para a realização da pesquisa foi aprofundado como o brincar influência e contribui para o crescimento infantil, para tanto foi utilizado autores que enfatizaram a atuação do lúdico no crescimento de aquisição do aluno, a saber: Soares (2010), Vigotsky (2007), Silva (2012), Malaquias (2013), Barbosa (2010), Violada (2011), Lima Junior (2017), Souza (2015), Almeida (2014) dentre outros citados. Para a metodologia foi utilizada a pesquisa exploratória, o estudo de caso bibliográfico, sob uma abordagem qualitativa. Durante o estudo foi constatado que ensinar ludicamente torna a aprendizagem mais significativa para o aluno, tais atividades tem o papel importante de auxiliar no desenvolvimento em diversos aspectos. Sendo assim é muito importante a ludicidade na vida, não só da criança, mas para todo ser humano.  Palavras-Chave: Aprendizagem; Brincadeiras; Jogos; Lúdico.---Abstract: This study aims to investigate the importance of play in the teaching-learning process and in child development. This analysis is justified by the conjecture that playfulness has a great influence on the process of child evolution, as it is through play that child amplifies their senses, and provides a better way to express themselves. To carry out the research, it was deepened how playing influences and contributes to child growth, authors who emphasized the role of play in the growth of student acquisition were used, namely: Soares (2010), Vigotsky (2007), Silva (2012), Malaquias (2013), Barbosa (2010), Violada (2011), Lima Junior (2017), Souza (2015), Almeida (2014) among others cited. For the methodology, exploratory research was used, the bibliographic case study, under a qualitative approach. During the study it was found that teaching playfully makes learning more meaningful for the student, such activities have an important role to assist in development in several aspects. Therefore, playfulness in life is very important, not only for the child, but for every human being. Keywords: Learning. Playfullness. Games. Ludic.
Combination of osteogenesis imperfecta and type 1 diabetes mellitus
Authors: Marmalyuk D. A. , Runova G. E. , Moshenina S. E. , Shapka M. P. , Fadeyev V. V.
Published: January 2022

Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder accompanied by increased bone fragility. Five types of OI are distinguished on the basis of phenotypic manifestations. OI type 1 is characterized by a reduced amount of normal type 1 collagen and is the mildest form. In addition to the fractures, course of disease can be accompanied by short stature, skeletal deformity and joint hypermobility. Although fracture risk decreases with age, such patients needs regular follow-up with an assessment of bone mineral density (BMD) and, if necessary, correction of therapy to improve the quality of life. Type 1 diabetes mellitus (T1DM) is associated with a decreased BMD, which is mostly attributed to insulin deficiency and hyperglycemia, which also increase the risk of fractures. Achieving and stable maintenance of glycemic targets is often challenging, but it is necessary to exclude hyperglycemia as a factor that further worsens the quality of bone. This paper describes a clinical case of an extremely rare combination of type 1 OI and T1DM, two diseases with a pronounced negative effect on bone tissue. The combination of these pathologies requires special management tactics for such patients to reduce the risk of developing new fractures.
The role of advanced glycation end products in patogenesis of diabetic nephropathy
Authors: Gavrilova A. O. , Severina A. S. , Shamhalova M. S. , Shestakova M. V.
Published: January 2022

Diabetes mellitus (DM) and chronic kidney disease are the diseases that have exceeded epidemic thresholds in terms of prevalence all over the world. That made it possible to classify them as non-communicable epidemics of the XXI century. Diabetic nephropathy (DN) is implicated with high levels of disablement and mortality. Advanced glycation end products (AGE) play a key role in the progression of DN. Increased formation of AGE occurs due to hyperglycemia under the conditions of diabetes. Moreover, there are additional factors in DN that increase the elaboration of AGE, such as high levels of oxidative stress and decreased renal clearance which slows down the AGE excretion. Both immediate effects of AGE and interaction of AGE with its cell-bound receptor (RAGE) result in a сascade of events that lead to further progression of DN. Thus, the research of the new therapeutic approaches targeted on the AGE-RAGE system is of great interest to slow progression of DN and improve the prognosis.
Educação popular e os movimentos sociais do campo
Authors: Araújo Aline Praxedes de , Silva Severino Bezerra da
Published: January 2022

Este artigo apresenta uma reflexão acerca da educação popular presente no Movimento dos Trabalhadores Rurais Sem Terra (MST) e no Movimento da Mulher Trabalhadora Rural – Nordeste (MMTR-NE) enquanto uma Pedagogia Decolonial. A questão orientadora de nossa pesquisa é: como a educação popular pode contribuir no MST e no MMTR-NE para o desenvolvimento de uma Pedagogia Decolonial? O estudo, de caráter ainda exploratório, adota uma metodologia de abordagem qualitativa e de cunho bibliográfico. Concluímos que o processo educativo existente no MST e no MMTR-NE deságua na desconstrução do projeto tradicional do uso e propriedade da terra no Brasil e dialoga com a construção de um pensar e fazer vinculados a uma Pedagogia Decolonial, tendo como perspectiva a construção de um projeto alinhado a uma sociabilidade alternativa para o campo agrário brasileiro e ao fortalecimento da identidade camponesa.
trabalho pedagógico sobre resíduos sólidos no ensino fundamental em escola do campo
Authors: Friedrich João Luis , Poletto Rodrigo Souza
Published: January 2022

O aumento populacional promove o consumo, a exploração e a degradação ambiental. Logo, a escola tem um papel fundamental de conscientização. Este artigo se consagra como uma revisão sistemática de literatura sobre práticas pedagógicas sobre resíduos sólidos, na temática da Educação Ambiental, no ensino fundamental em escolas do campo. A metodologia foi uma investigação em três bases de dados, no período de dezembro de 2020 a janeiro de 2021, sendo elas: Biblioteca Digital Brasileira de Teses e Dissertações do Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT), Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e na Plataforma Sucupira, por meio da Qualis Periódicos, na área de Ensino, triênio 2010-2012 e quadriênio 2013-2016, nas classificações A1, A2, B1 e B2. Foram pesquisados 6.053 trabalhos. A pesquisa demonstrou que, apesar de inúmeras publicações, apenas dois trabalhos contemplaram a temática resíduos sólidos no ensino fundamental em escolas do campo. Indica-se, assim, um vasto campo para pesquisas, que resultam em metodologias, conteúdos e práticas para professores que atuam nesse contexto.
coordenador pedagógico em espaços de educação não formal
Authors: Mendonça Juliana Munhoz , Leite Vania Finholdt Angelo
Published: January 2022

A luta pela democratização do acesso ao ensino superior obteve resultados significativos, em termos de políticas públicas, nas últimas três décadas. No entanto, outras formas de engajamento social fazem parte desse cenário, como os Pré-Vestibulares Populares (PVP). O presente estudo buscou compreender como a gestão se organiza nesses espaços, especialmente a partir do papel dos coordenadores pedagógicos. Quanto à metodologia, realizou-se aplicação de questionário com oito coordenadores de quatro PVP, com o intuito de obter informações acerca dos PVP e de suas funções enquanto gestores, através do olhar desses próprios sujeitos. Ao final, evidenciou-se que a atuação dos coordenadores busca alcançar os objetivos do projeto dos pré-vestibulares para que os estudantes possam ingressar na universidade, mas, principalmente, com a formação humana e cidadã, para se tornarem pessoas atuantes na sociedade, críticas e autônomas.
Educação em saúde com adolescentes quilombolas como estratégia de construção da paz
Authors: Santos Vanessa Cedraz dos , Morais Aisiane Cedraz , Souza Sinara de Lima
Published: January 2022

O objetivo deste trabalho consiste em relatar a experiência extensionista em uma escola pública com adolescentes quilombolas tendo a educação em saúde como estratégia para construção da paz. A metodologia considerou a utilização do método participativo e o desenvolvimento de atividade lúdica entre adolescentes de 11 a 18 anos pertencentes à escola municipal da comunidade negra rural quilombola localizada na zona rural de Feira de Santana-Ba. Resultou-se no desenvolvimento das atividades que favoreceram a promoção da autoestima, autoafirmação racial e o resgate à identidade do adolescente negro, contribuindo com empoderamento para enfrentar o racismo/violência e o reforço às estratégias de construção da paz. A metodologia utilizada possibilitou a aproximação dos alunos à nova forma de atividade. Compreende-se os prováveis fatores que motivam a violência entre os adolescentes e constata-se a necessidade da continuidade de ações educativas.
Aspectos educativos das lutas contemporâneas em defesa da educação pública
Authors: Godoi Evandro de , Samborski Tarcísio
Published: January 2022

Este texto está inserido nas discussões acerca dos movimentos sociais populares e sua articulação em torno da luta pela educação. O artigo apresenta os resultados e reflexões de uma pesquisa qualitativa, desenvolvida com o objetivo de compreender alguns aspectos educativos presentes nas lutas contemporâneas em defesa da educação pública. Para tanto, foi desenvolvido um estudo documental sobre os materiais produzidos e divulgados pelos coletivos convocatórios do I Encontro Nacional de Educação (ENE), realizado em 2014 no Rio de Janeiro-RJ. Os materiais coletados foram submetidos aos procedimentos da Análise Textual Discursiva (ATD) e as categorias da pesquisa foram obtidas de forma indutiva e contextualizadas com referencial teórico crítico sobre as políticas educacionais. A investigação evidenciou como pressupostos implicados na luta pela educação pública: a necessidade de rearticulação dos sujeitos organizados e a reafirmação da educação pública como um direito social e a resistência à fragmentação e mercantilização crescentes no campo educacional a partir do cenário dado pelas políticas educacionais.
Phytochemical Screening, Antioxidant and Antibacterial Activities of the Root Extract of Cyphostemma adenocaule (Steud. ex A. Rich.) Wild & R.B.Drumm
Authors: Yakubu Abdulbasit Haliru , Mohammed Mohammed Mustapha , Bababe Abdulqadir Bukar , Braimah Hassan Yesufu
Published: January 2022

Plant secondary metabolites have provided important bioactive principles for developing new lead compounds. Within their confinement, they exhibit unique chemical diversity, which influences their diverse biological properties. The Vitaceae family is known for its potent antioxidant and antibacterial phytoconstituents, among other biological properties. Cyphostemma adenocaule is one of the family members explored for its ethnomedicinal properties. This study undertook the evaluation of the phytochemical, antioxidant, and antibacterial properties of the root extract of Cyphostemma adenocaule. Preliminary phytochemical screening revealed the presence of flavonoids, alkaloids, carbohydrates & glycoside, saponins, and tannins. The methanol root extract had the highest activity in the DPPH assay, providing IC50 (50% inhibition) of 10.87Âµg/ml, followed by n-Hexane (IC50 74.10Âµg/ml) and chloroform (IC50 74.31Âµg/ml) extract. In the antibacterial assay, the chloroform extract was active against E. coli (24.00Â±0.15) and had moderate activity against Staph. aureus (12.5Â±0.18). The n-Hexane extract was completely inactive against the test organisms while the methanol extract showed poor activity against the test organisms. The present study adds to the existing literature on Cyphostemma adenocaule with scientific evidence into its biological properties.
Acute Toxicity and Hypoglycemic Effect of a Polyherbal Formulation on Blood Glucose in Oral Glucose Tolerance Test (OGTT) and Alloxan-Induced Diabetic Rats
Authors: Warri Abednego Okeoghene , Moke Emuesiri Goodies , Balogun Aishat Oyinkansola , Nzeh Kennedy Chibogu , Umukoro Emuesiri Kohworho , Erhirhie Earnest Oghenesuvwe
Published: January 2022

Madam F. Kayes BittersÂ® is an herbal formulation commonly used in Nigeria and some African countries in the management of diabetes mellitus and other diseases conditions. This study evaluated the in-vivo hypoglycaemic activity, as well as acute toxicity of the polyherbal formulation to provide its efficacy and safety. Healthy albino mice (20-30 g) and Sprague Dawley female rats (90-130 g) were used for this study. Acute toxicity study (LD50) of the herbal formulation was determined by methods originally described by Miller and Tainter in 1994. Following oral dosing with glucose (2 g/kg) in normal fasted animals, herbal formulation (HF) at various doses was administered and blood glucose levels at 30 minutes, 60 minutes, 90 minutes, and 120 minutes were taken and recorded. Diabetes was induced using alloxan 150 mg/kg and diabetic rats were given the HF at doses of 50, 100, and 200 mg/kg with glibenclamide 2.5 mg/kg used as standard drug treatment. Blood glucose level was determined on 1st day, 7th day, 14th and 21st day. The LD50 was greater than 5g/kg with oral administration. The oral glucose tolerance test showed that the group that received 100 mg/kg HF showed a significant reduction (p<0.05) in glucose level after 120 minutes when compared to the basal level of glucose recorded. All treated diabetic groups showed a significant decrease in glucose level on the 21st day. The herbal formulation of Hydrastis canadesis Aloe capensis, Echinacea angustifolia and honey exhibited a significant glucose-lowering activity in alloxan-induced diabetic rats.
Moderating role of government Acts, laws and policies between team competency and skills and construction risk management among KSA contractors
Authors:   School of Civil Engineering, Universiti Sains Malaysia (USM), Malaysia, Rehman Muhammad Abdul , Ishak Md. Sayuti Bin ,   School of Civil Engineering, Universiti Sains Malaysia (USM), Malaysia
Published: January 2022

Contractors have given importance to risks in the construction process as it causes time and cost overrun, delays, and total desertion in activities and events present in the construction project. The uncertainty in the completion time, cost, and quality during construction relate to construction risks. Project goals are achieved by classifying, investigating, and replying to risks associated with construction projects. To achieve project objectives, team competency and skills are required, which are viewed as attitude, aptitude, versatility, and knowledge. Based on organisation control theory, current research (quantitative in nature) discusses the influence of team competency and skills on construction risk management with the moderation role of government Acts, laws, and policies among 303 large-size contractors working in the Kingdom of Saudi Arabia using PLS-SEM technique. PLS-SEM is a composite-based approach that provides high efficiency parameter estimation with increased statistical power for analyzing complex models. Results depict that government Acts, laws and policies and team competency and skills positively influence construction risk management. In addition, moderation of government Acts, laws, and policies has positive relation among team competency and skills and construction risk management. Organisational management can reduce risk occurrence within a project by building conditions for enhancing team competency and skills.
A model for measuring distruption risk in the prefabrication supply chain
Authors:   University of Oklahoma, USA, Ghosh Somik , Hamad Mustafa ,   McCarthy Building Companies, USA
Published: January 2022

Use of prefabrication in construction projects is increasing due to the benefits in cost, time, quality, and safety. However, utilizing prefabrication introduces uncertainties inherent with the supply chain of the process. These uncertainties, if not managed, can disrupt the prefabrication process and result in schedule delays and cost overruns. This study proposes a model to measure disruption risks in the prefabrication process. The model was used in measuring the disruption risks of prefabrication of headwalls in patients’ rooms for a healthcare project as a pilot study. The risk model could successfully identify the disruption risks originating anywhere in the supply chain based on input information such as required material quantity, batch sizes of material deliveries, production rates, and batch sizes of transporting the headwall units. Using the model, the project team identified two uncertainties that could lead to possible disruptions: the start of the prefabrication processes and the required production rate to meet the on-site schedule. This is a first step to developing a risk exposure model that can prove valuable to the risk managers to analyse and manage the impact of disruptions. This will help the risk managers in making informed decisions about where to focus their limited resources.
Practical Wisdom Reasoning through Deliberative Pedagogy
Authors: Lawrence Windy , Rountree John , Drury Sara
Published: January 2022

Deliberative pedagogy holds promise for improving democratic society by cultivating practical wisdom in students as a means to tackle the problems of democracy, such as polarization. This study embraced an opportunity to consider civic education in the 21st century through deliberative pedagogy by considering practical wisdom in a synchronous, virtual deliberation among university stakeholders and local political candidates concerning our role in 21st-century politics. This civic site enabled an analysis of practical wisdom across three student roles: facilitators enrolled in a deliberation course; students from the wider university; and student alumni of the university’s deliberation center, who had been exposed to deliberation in curricular and cocurricular practice. Using a constructive rhetorical analysis to understand practical wisdom within deliberative pedagogy discourse, we contend that students in these three different roles demonstrated three key aspects of practical wisdom through their discursive responses to rhetorical exigences that arose during deliberative engagement. This analysis offers insights beyond outcomes and informs deeper thinking about curricula and better pedagogical practices. Additionally, such studies, focused on the discourse itself, contribute to understandings concerning the connection between rhetoric and deliberative pedagogy.
THE INFLUENCE OF TRAINING SESSIONS OF NORTHERN (SCANDINAVIAN) WALKING ON THE PARAMETERS OF THE FUNCTIONAL STATE OF MEDICAL UNIVERSITY STUDENTS
Authors: Bocharin I. V. , Guryanov M. S. , Martusevich A. K.
Published: January 2022

In this article, the purpose of the study was a comparative analysis of the parameters of the functional state of the body of students under the systematic influence of moderate physical exertion of northern (Scandinavian) walking. The study included 85 second-year students of the Volga Research Medical University. To visualize the indicators of the state of the body, the system of sports testing “MedicalSoft” was used. The functional status of the students' organism was studied before the start of Nordic (Scandinavian) walking classes, and after the completion of a two-month course of exposure to metered physical exertion. The analysis of the data obtained was carried out in accordance with the age standards that were formed by the developers of the equipment. It is established that systematic health-improving and training loads favorably affect the state of the body of the subjects, increasing its adaptive capabilities, which is confirmed by dynamic changes in the values of integral indicators.
DETECTION OF POTENTIALLY UNRELIABLE VLSI BASED ON THE ANALYSIS OF TEMPERATURE-SENSITIVE PARAMETERS
Authors: Bulaev I. Yu. , Koulibaba A. Ya. , Silin A. S.
Published: January 2022

The paper discusses methods for non-destructive diagnostic testing of very large scale integration circuits (VLSI) based on the “junction-case” thermal resistance parameter. This parameter is important because VLSI’s failure rate depends on junction temperature, which in turn depends on thermal resistance “junction-case”. There are three known methods for detecting potentially unreliable VLSIs with increased thermal resistance value: 1) non-destructive measurement of thermal resistance; 2) scanning acoustic microscopy; 3) an approach based on the statistical analysis of temperature-sensitive electric parameters. The paper presents advantages and disadvantages of each method. Special attention is paid to statistical analysis of temperature-sensitive electric parameters because this method allows detecting of potentially unreliable VLSIs without using expensive equipment. This method does not require changes in existing measurement programs. Electric parameters, which depend on temperature, are temperature-sensitive parameters. These parameters are useful for detecting VLSIs with deviations from the main batch. This allows decreasing of risk of potentially unreliable VLSIs application in high reliable equipment. With the proposed approach the high reliable equipment lifetime can be increased.
ON THE APPLICATION OF DISPERSION ANALYSIS FOR QUALITY ASSESSMENT OF A QUARTZ UV IRRADIATOR
Authors: Balandin D. D. , Lyubimtseva O. L.
Published: January 2022

Ensuring and improving the quality of products is currently an urgent task implemented through product quality management. In connection with the spread of the COVID-19 virus, Rospotrebnadzor recommends the use of quartz lamps when disinfecting premises. The article discusses the issue of assessing the quality of a device for home use of a quartz ultraviolet irradiator OUFK-01. In accordance with the WHO recommendations, the irradiation indicator became the main one for the study. The study was carried out using an ANOVA model with several iterations. Purpose of the study: to study the variability of the irradiance index in different UV ranges depending on the source of UV radiation (UV lamp) of the ultraviolet irradiator OUFK-01. The main advantage of the analysis of variance was used – the ability to consider the interaction of various factors. The conclusions that were formulated based on the results of analysis of variance suggest that the quality of the OUFK-01 irradiator has changed. Data processing was carried out using the MS EXCEL software package. The article provides a rationale for what is meant by “quality improvement”, namely, in order not to violate the bactericidal effect, it is necessary to reduce the UV-A and UV-B ranges to acceptable values, since the effect of UV-C rays has not been fully studied, then the irradiance should be increased to the permissible wavelength range. A comparative analysis of successively modified products showed that the quality of the device increased with the replacement of the UV lamp.