bluuebunny/crossref_metadata_2025 huggingface dataset:
Language tools with an intensifying function in V. M. Shukshin’s novella “Snowball Berry Red”
Authors: Loginova Elena Yurievna
Published: July 2024

The purpose of the study is to determine the features and role of linguistic means with an intensifying function, identified in V. M. Shukshin’s novella “Snowball Berry Red”. The detected units are part of the representative base of the intensity category, which, following the majority of researchers, we recognize as a qualitative and quantitative semantic category. The semantic category of intensity is for V. M. Shukshin is a means of stylistic reinforcement, focusing attention on one or another side of the depicted reality, a way of characterizing the hero, expressing his feelings, a means of clarifying assessments, as well as a way of compositional division of the text. The scientific originality is determined by the fact that for the first time the peculiarity of the language of V. M. Shukshin’s novella was investigated from the point of view of the existence of means with amplifying semantics in it, their role in the text of this literary work was established. The results showed that V. M. Shukshin makes extensive use of multilevel linguistic means of expressing classifiers and intensifiers: lexico-phraseological, morphological, syntactic. Along with other means involved in the formation of the author’s idiostyle, they contribute to the transmission of various semantic and emotional shades of the described speech situations. At the same time, the writer conveys his attitude to the depicted, organizing the text in a special way and selecting linguistic means that materialize the artistic image.
The sound-symbolic potential of vocabulary in the work of E. D. Luchezarnova
Authors: Naumova Elena Vladimirovna , Shkarin Dmitry Leonidovich
Published: July 2024

The purpose of the study is to identify the specifics of the author's word formation in the work of E. D. Luchezarnova. The article proves that most of the author's neologisms within the rhythmological concept are based on the sound-symbolic phonetic significance, which gives the character of ornamentation to the texts as a structural principle of text formation. The methodology of the conducted research is presented and the data of psychosemantic experiments based on the semantic differential are presented. The scientific novelty of the study lies in the fact that a comparative analysis of the results of automated and audit studies shows the phonetic motivation of the occasionalisms that form the conceptual basis of E. D. Luchezarnova’s rhythmological concept. The results of qualitative and quantitative psycholinguistic analysis allow us to identify the complex internal structure of perception of rhythmological vocabulary. Based on the data obtained, it becomes possible to model the process of assimilation of the rhythmological concept, and prospects for the interpretation of E. D. Luchezarnova’s texts are outlined, taking into account the principles of ornamentalism.
Factors of non-linearity in the collection of stories “Severance” by R. O. Butler
Authors: Simonova Elena Petrovna
Published: July 2024

The aim of the research is to identify the factors of non-linear reading of an English ergodic text, describing the linguistic mechanism of stimulating non-linear perception of information. The paper is devoted to the study of an English ergodic literary text, the structure of which is characterized by openness and dynamism. The key principle of the organization of this type of text is the possibility of its non-linear reading. The paper considers the concept of non-linearity of the text, the relationship of non-linearity with hypertext, describes the structure of the ergodic text, the features of its speech organization, and identifies the factors that determine the non-linear reading of texts of the ergodic genre. The research is original in that it is the first to consider the English-language collection of stories “Severance” by R. O. Butler as an ergodic literary text, its linguistic and stylistic features are described taking into account its non-linearity. As a result, the researcher found that such paratext elements as intermediate titles belong to the factors of non-linearity at the level of text architectonics. The openness of the text was proved by its intertextual connections, implemented through precedent names. It was substantiated that at the level of speech organization, the stream of consciousness can also be considered as a factor of non-linear reading.
Feelings and sensitivity in medieval Italian visions (based on the poetry of the turn of the 13th-14th centuries)
Authors: Kedrova Mariia Alexandrovna
Published: July 2024

The purpose of the study is to analyze three poems of the turn of the 13th-14th centuries to identify the feelings and emotions of the heroes, inhabitants of the afterlife, followed by an explanation of the functions of representation of the selected phenomena in the texts. The material for the article was the poems written in the folk language by the Italian didactic poets Bonvezin da la Riva (“The Book of Three Scriptures”) and Giacomino da Verona (“Infernal Babylon” and “Heavenly Jerusalem”). The scientific novelty of the work consists in identifying the tropes and motifs by which the authors of the selected poems represent a particular feeling. As a result, it is determined that the feelings described and called by the selected authors are staged in accordance with the role-playing nature of the genre of vision. Bonvezin da la Riva’s “Black Scripture” and Giacomino da Verona’s “Infernal Babylon” are more original and rich in tropes (epithets, metaphors, etc.) than the images of paradise. The description of sins in Bonvezin’s work is more moderate, while Giacomino da Verona refers to the folk laughing culture. It was found that Bonvezin’s target audience were monks, and the comic component of “Infernal Babylon” was aimed at the general public.
Validation of an Analytical Procedure for Evaluating the Biological Activity of a Medicinal Product Based on Tocilizumab and Determination of Acceptance Criteria for Test Results
Authors: Nikonova Yu. A. , Abbasova S. G. , Kargopolova P. E. , Strizhakova O. M. , Lyagoskin I. V. , Vasilev A. P. , Pershin A. S.
Published: July 2024

INTRODUCTION. Bioanalytical techniques are characterised by greater variability and lower stability than physicochemical methods because live test systems are inherently labile. Since regulatory standards do not establish a unified approach, the selection of system suitability criteria and acceptance criteria for test results is based on validation studies.

AIM. This study aimed to validate an analytical procedure for evaluating the biological activity of a medicinal product based on the investigational tocilizumab biosimilar GNR-087 and determine the quantitative limits for system suitability criteria and acceptance criteria for test results.

MATERIALS AND METHODS. The biological activity of the investigational tocilizumab biosimilar was assessed by the inhibition of IL-6-induced secreted embryonic alkaline phosphatase (SEAP) expression by HEK-Blue™ IL-6 cells. Statistical processing of the obtained results was performed using Prism 6.0 software.

RESULTS. The specificity of the analytical procedure was confirmed by the dose-dependent inhibition of IL-6-induced SEAP expression by cells observed with tocilizumab. The analytical procedure was linear, with a coefficient of determination R2≥ 0.99. The precision of the analytical procedure was satisfactory; its repeat ability varied from 2 to 9%, and its intermediate precision was 14%. The recovery coefficients (Rc) for spiked samples simulating activity levels of 60–140%, including blinded samples, ranged from 80 to 120%. The theoretical values of relative potency (RP) were within the confidence intervals of the mean relative potency estimates, which confirmed the accuracy of the analytical procedure. The validation confirmed the robustness of the analytical procedure to controlled variations, including the use of reporter cells at different passages (with a coefficient of variation for relative potency estimates (CVRP) of 10%), different IL-6 lots (with a CVRP of 1%), and different SEAP detection reagent lots (with a CVRP of 3%); the Rc remained in the range of 80–120% of the nominal RP value.

CONCLUSIONS. The analytical procedure for evaluating the biological activity of the investigational tocilizumab biosimilar meets the validation criteria, including accuracy, linearity, precision, specificity, and robustness. The study established system suitability criteria and acceptable limits for biological assay results. This analytical procedure can be used both for routine biological activity control and for demonstrating the biosimilarity of new medicinal products to the original (reference) tocilizumab-based medicinal product.
Determination of Biological Activity of Gonadotrophins in Randombred and Sprague Dawley Rats. Part 2. Determination of Biological Activity of Luteinising Hormone
Authors: Batuashvili T. A. , Chechetova E. O. , Shadrin P. V. , Neugodova N. P.
Published: July 2024

INTRODUCTION. The tendency towards reducing the use of laboratory animals in pharmaceutical quality assessment, along with the development of new technologies for gonadotrophin production, necessitate the development of novel assays to determine the biological activity of natural and recombinant anterior pituitary preparations.

AIM. This study aimed to select the optimum conditions for the determination of the biological activity of luteinising hormone (LH) in urinary and genetically engineered LH preparations by tests in randombred and Sprague Dawley rats.

MATERIALS AND METHODS. The biological activity of urinary and recombinant LH preparations was determined in vivo in a three-dose randomised Steelman–Pohley bioassay, which compared the biological activity of the test samples to a reference standard (RS). The analysis used two years’ worth of test results. The RS used was the WHO international standard containing 183 IU of follicle stimulating hormone bioactivity and 177 IU of LH bioactivity per ampoule. The bioassay was performed in immature male randombred and Sprague Dawley rats; the bioassay conditions were selected according to the rat type.

RESULTS. The results of the in vivo determination of LH biological activity in male rats were compared by the standard deviation to slope ratio (s/b), which helps estimate response variation and dose dependence at the same time. The study demonstrated the possibility of using Sprague Dawley rats (s/b=0.82±0.44) for the determination of LH biological activity along with randombred animals (s/b=0.68±0.58). The s/b ratios were close, although Sprague Dawley rats and randombred rats were used in the assay at a 1:2 ratio.

CONCLUSIONS. It is possible to determine the biological activity of LH from menopausal gonadotrophin preparations in both randombred and Sprague Dawley male rats. The use of Sprague Dawley rats for testing can confirm the reliability of test results using fewer animals than needed for standard tests; this is not only humane but also cost effective.
Basic Principles for Calculating the Required Number of Participants in Clinical Trials. Part 1. Common Approaches (Review)
Authors: Shreder O. V. , Goryachev D. V. , Merkulov V. A.
Published: July 2024

INTRODUCTION. A well-planned design of a clinical trial (CT) ensures valid results in assessing the efficacy and safety of medicines for human use. However, at present, there are no clear criteria for selecting the basic elements underlying the development of a CT design. This lack of selection criteria primarily concerns planning research hypotheses, calculating the expected therapeutic effect, statistical significance level, and study power, and selecting statistical models for sample size calculation.

AIM. The authors aimed to systematise and harmonise the technical requirements for sample size determination in designing CTs.

DISCUSSION. First, this article describes the basic requirements for and methodological approaches to designing CTs to assess the efficacy of medicines and to confirm their safety. Next, the article presents the basic principles for calculating the sample size to ensure the required CT power. Finally, the article covers the mathematical models describing the null and alternative hypotheses used in the development of basic statistical designs for efficacy and safety studies. A general requirement for the quality of a study sample is to ensure its representativeness, that is, its compliance with the target CT population. The selection of a mathematical (probabilistic) model to formulate research hypotheses and calculate study samples representative of the target population is based on general data from systematic reviews of previous studies on the therapeutic effects of the study product and the specific characteristics of the target population. In addition, model selection relies on the classification of the study product. Sample size calculation requires defining and justifying certain criteria at the stage of CT design and statistical model development, in line with the general requirements for representativeness. Software for calculating the statistical power and required sample size facilitates routine CT planning.

CONCLUSIONS. The sample size determination requires more than the application of basic statistical models. Given the multitude of CT designs and methodological approaches to CT planning, treatment regimens, and data collection and analysis, it is necessary to consider the statistical design of each CT on a case-by-case basis. This consideration should include assessments of individual cases, survival analysis methods, relative risks, diagnostic tests, and adaptive and other infrequent CT designs. The above highlights the need to develop additional guidelines and information resources that would explain and demonstrate the use of probabilistic statistics. The resulting national standards should be harmonised with international standards.
Recommendations for the Content of a Product Specification File: Water (Karl Fischer Method)
Authors: Vaganova O. A. , Natykan A. A.
Published: July 2024

This article provides recommendations for documenting an analytical procedure for water determination by Karl Fischer titration in a product specification file (PSF). The article contains a description of specific aspects associated with the test and a template for the typical content and layout of the corresponding PSF section. A unified approach to the PSF content and layout will ensure error-free testing, reliable results, and streamlined regulatory assessments.
The effectiveness of the use of phytobiotics in feeding laying hens
Authors: Latypova Yekaterina N. ,   JSC “Borovskaya Poultry Factory name A.A. Sozonov”, Тyumen region, Russia, Shatskih Yelena V. ,   FSBEI HE “Ural State Agrarian University” (FSBEI HE Ural SAU), Sverdlovsk region, Russia
Published: July 2024

The article presents an analysis of egg productivity, feed consumption per head and unit of production, the safety of replacement young animals and laying hens, and the economic effect of introducing phytobiotic feed preparations into compound feed.
Freshgraduate Motivation of Stikes Yarsi Mataram as Careworkers To Japan Through The Kaigho Fukushi-Shi Peer Support System
Authors: Putri Rusiana Harlina , Istianah  , Lalu Amri Yasir  , Dewi Nur Sukma Purqoti
Published: July 2024

The increasing number of nursing graduates with limited employment opportunities is a problem in almost all regions in Indonesia. Many work as voluntary nurses with salaries far below the regional minimum wage. Meanwhile, in Japan, the need for nurses as Kaigo Fukushi-shi (Caregiver) is very high. Through the Indonesia-Japan Economic Partnership Agreement (IJ-EPA) an agreement is made to send 1,000 careworkers every year. However, it only succeeded in sending 826 people in a span of 3 years through the G to G program. This study aims to measure the level of differences in the motivation of new graduates of STIKES YARSI Mataram before and after receiving assistance through the Kaigho Fukushi-shi Peer Support System from Alumni. The method used in this research is the Quasy Experiment without a control group with a total sample of 25 people. Obtained a p-value of 0.000 with a motivation value at the positive mean rank of all participants. It can be concluded that there is an influence from the Kaigho Fukushi-shi Peer Support System of the Alumni on the motivation of new graduates to work in Japan. Through this research, it contributes to the institution to be ready to use its graduates to gain experience working in Japan.
The Most Influential Factors of Hypertension Grade Among Patients Aged 45-75 In the Community Health Center of North Kediri City
Authors: Radono Panca , Samuel Kaka  , Dhita Kurnia Sari
Published: July 2024

Hypertension, often referred to as the silent killer, is a deadly disease that often shows no symptoms until it is too late. Understanding the factors that contribute to its incidence is crucial. In this observational cross-sectional study, 263 hypertensive patients aged 45-75 years were examined to determine the influential factors. Using purposive sampling, a sample of 42 respondents was chosen. The independent variables studied were diet and activity patterns, while the dependent variable was the occurrence of hypertension. The statistical analysis was conducted using ordinal regression. The findings revealed that 64.3% of hypertensive patients aged 45-75 years had an improper diet, while 45.2% had poor activity patterns. Grade I hypertension was observed in 40.5% of the respondents. The data analysis indicated a significant influence of diet, activity, and hypertension (p = 0.00 < α = 0.05). Furthermore, the wald value of 17,286 suggested that diet had a greater impact. The study concluded that diet was the most influential factor, emphasizing the importance of avoiding high-cholesterol foods (e.g., fried and coconut milk-based dishes), fatty meats, and high-salt foods (e.g., pickles). These findings highlight the need for individuals to be mindful of their dietary choices to prevent and manage hypertension effectively.
Description of Parent's Knowledge About Bias Immunization for Grade 1 and 2 Students at MI Al Irsyad Kediri City
Authors: Erna Rahmawati  , Angraini Dyah Setyarini
Published: July 2024

Immunization is one of the government's efforts to strengthen children's immunity and prevent millions of deaths and disabilities. Vaccination is carried out in primary schools, especially grades I and II, as a program of community health centers under the BIAS format. (Student Immunization Month) takes place in the form of measles vaccination in August and tetanus DT (Diphtheria) vaccination in November. Parental knowledge plays a very important role in implementing the program  BIAS vaccination, so that children do not get diseases that can be prevented by vaccination. The purpose of this study was to descriptively analyze parents' knowledge of BIAS vaccination in grade 1 and 2 students at MI Al Irsyad, Kediri city. This type of research used a quantitative descriptive method with a total of 64 respondents using a simple random sampling technique. Data collection in this study used questionnaires. The analysis used was a univariate analysis. Result of the univariate analysis showed that the highest level of parental education was high school with 39 respondents (60.9%), the type of work most respondents did was housewife with 21 respondents (32.8%), and a good level of knowledge for 28 respondents (44). %).Conclusion was that parental knowledge about BIAS immunization was quite good, in this case it can be seen from the results that 28 respondents (44%) had parental knowledge.
Ergonomic Exercise Effects on Cholesterol in Elderly in LKS (Social Welfare Agency) Love House Jambon
Authors: Yalestyarini Eva Agustina , Hana Nurjannah , Ririn Nasriati  , Muftiana Elmie
Published: July 2024

Elderly (elderly) is a part of the process of human development. As we get older, physiological functions decrease which causes various health problems. One of the health problems in old age is an increase in blood cholesterol levels. Total cholesterol in the blood increases with the aging process. One way to reduce cholesterol levels is to do ergonomic exercises to restore or correct the position and flexibility of the nervous system and blood flow. The purpose of this study was to analyze the effect of ergonomic exercises on cholesterol levels in the elderly at LKS Rumah Kasih Jambon. The research design is a quantitative quasy experiment with a one group pretest posttest design approach. The sample in this study were 15 respondents who were given routine ergonomics exercise 4 times a week for 2 weeks. Sampling in this study was carried out in a non-probability way using a purposive sampling technique. The results of the Paired Sample t-test statistic showed that there was an effect of ergonomic exercise on cholesterol levels in the elderly at the Jambon Love Care Center with p value = 0.000 (p <0.05). The results showed that the average blood cholesterol levels before and after the ergonomic exercises were 240.73 mg/dl and 230.40 mg/dl. The difference in cholesterol levels before and after ergonomics exercise was 10.33 mg/dl.
Implementation Of Occupational Health And Safety Culture In Maintaining Zero Accident Stability For Workers In Sugar Factories
Authors: Ema Mayasari  , Erina Esa Aisyarah
Published: July 2024

The application of occupational safety and health provides several benefits in every aspect of human life and provides benefits in every business activity and supports the progress of quality and sustainable development in the human resources, economic, social and environmental aspects. This research aims to find out and explore the application of occupational safety and health culture in maintaining zero accident stability. The informants in this research consisted of 4 main informants, namely installation workers, and 2 triangulation informants, namely occupational safety and health. The data analysis techniques used in this research are reduction, display and verification. Based on the research results, it was found that the implementation of occupational safety and health culture among production workers at the Sugar Factory where the research took place was classified as good and at an independent level, workers realized that work safety was a shared responsibility. Efforts to maintain zero accident stability include implementing good internal occupational safety and health communication, implementing discipline, monitoring and high work standards, and also in terms of investigating incidents the Company carries out quickly and responsively. However, during field observations, it was still found that workers were using incomplete PPE. The obstacle felt by workers and occupational safety and health parties is the return of PPE stock which sometimes takes a long time.
Effect of Covid-19 Pandemic on Availability and Delivery of Sexually Transmitted Infections Health Services and Products to Individuals 15 - 49 Years in Lusaka: A Case Study of Chelstone
Authors: Mwale Ganizani , Makasa Mpundu
Published: July 2024

In Zambia, approximately 5% women and 8% men aged 15-49 reported having a Sexually Transmitted Infection (STI) 12 months prior to the Zambia Demographic Health Survey of 2018. Notably 62% women and 73% men who had an STI sought treatment at the clinic, signifying importance attached to health services by STIs treatment seekers. Regrettably during the COVID-19 pandemic entry points to STIs health services were closed. An explanatory sequential mixed-methods approach was used to investigate access, availability, and delivery of STIs health services. In-depth interviews with ten clinicians selected using criterion purposive sampling were held. The availability and delivery of STIs health services encountered challenges including truncated service points, hours, and interactions, affecting diagnoses of STIs. Stay-at-home orders, fear, lockdowns, and logistical challenges impeded access to STI health services. Flexible service delivery model uses to control pandemic-induced barriers in individual’s access to STIs health services must guide future pandemic responses.
Would you be willing to pay more if AI robot waiters were introduced? The pivotal role of the need for uniqueness and perceived uniqueness
Authors: Ramadhan Tri Sugiarti , Krisnanto Aditya Budi , Name No
Published: July 2024

Service robots have the potential to enhance customer experiences with their innovative technology, but many people still feel uncomfortable around them. While some customers are open to being served by robots, most still prefer interacting with humans.  This inconsistency highlights the need to explore why consumers choose robotic service restaurants over conventional ones.  This study aims to extend the existing literature by examining the need for uniqueness and perceived uniqueness as critical determinants of attitudes and willingness to pay more. To the best of the author's knowledge, there are few studies that explore these factors in the context of service robots, particularly in Indonesia. We surveyed 308 customers who dined at restaurants with robot waiters. Our analysis, using regression and Sobel, revealed that the need for uniqueness doesn't significantly affect how consumers feel about these restaurants or their willingness to pay more. However, perceived uniqueness positively affects both consumer attitudes and willingness to pay more, both directly and indirectly.  This means that while the need for uniqueness can motivate consumers to explore novel experiences like dining at a restaurant with robot waiters, restaurants must ensure that the overall experience meets or exceeds customer expectations to enhance positive attitudes and willingness to pay more.
Optimizing traffic management in Danang: a comparative study of multi-object tracking techniques for real-time vehicle flow monitoring
Authors: Ton Hai T. , Nguyen Hung V. , Tran Hanh T. M. , Thai Tien V. , Le Phong-Phu , Huynh Tung T. , Dao Duy-Tuan
Published: July 2024

This study evaluates the effectiveness of various detection-based object-tracking algorithms to optimize accuracy and efficiency in traffic flow monitoring. Due to its high accuracy in detecting objects, YOLOv8 was chosen as the vehicle detector for this research, where precise and rapid vehicle detection was critical. Regarding object tracking, our focus centered on the evaluation of five prominent Multiple Object Tracking (MOT) algorithms, including BoTSORT, ByteTrack, DeepOCSORT, OCSORT, and StrongSORT. We introduce a comprehensive traffic urban dataset collected from intricate street networks in Danang City. Our experimental results show that the system has practical applicability in urban traffic monitoring. Notably, the best model achieves a detection accuracy of 0.721 on mAP@0.5-0.95, and the High Overlap Tracking Accuracy (HOTA) surpasses 72% for tracking performance across diverse traffic scenarios. This shows the applicability of MOT algorithms and provides a detailed view of traffic flow monitoring, especially in Danang City, Vietnam.
Factors influencing Vietnamese students' decision to study in South Korea
Authors: Tin Pham Quang , Loan Le Thi Phuong , Giang Vo Thi
Published: July 2024

Vietnamese students have been encouraged to choose South Korea as their study abroad destination as a result of the rising popularity of Korean culture, technology, and science in Vietnam over the years. This study uses primary survey data from 161 Vietnamese studying in South Korea, according to the 5-level Lirket scale, along with quantitative analysis techniques such as scale testing, exploratory factor analysis, and regression analysis. The analysis’ findings indicate that there are seven aspects, including the training program, personal growth, language, career prospects, support, immigration prospects and cultural factor that influence Vietnamese students’ decisions to study abroad in South Korea. In order to develop reasonable policies to entice Vietnamese students to study in South Korea, Korean training institutes and organizations that promote Korean education abroad can use the research results as a credible quantitative basis.
A DFT study on substituent effects on iron corrosion inhibition capability of indole derivatives
Authors: Huong Dinh Quy
Published: July 2024

The corrosion inhibition activity of indole derivatives has been systematically examined by calculating quantum chemical parameters including energy of the highest occupied molecular orbital, energy of the lowest unoccupied molecular orbital, energy difference, molecular hardness, molecular softness, and the number of electrons exchanged between the metal and the corrosion inhibitor at the B3LYP/6-311++G (d,p) level of theory. The results demonstrate that derivatives containing the electron-donating groups exhibit superior efficiency in inhibiting iron corrosion compared to indole. Additionally, an investigation into the corrosion inhibition ability of derivatives containing the NH2 group reveals that 6-NH2-indole emerges as the most effective inhibitor, boasting an efficiency value of 97.11%. These calculated outcomes align with previously studied experimental results, underscoring the remarkable corrosion resistance of derivatives containing electron-donating groups.
Unveiling the Power of Blockchain in Pharmaceutical Supply Chains: Strengthening Security and Improving Drug Traceability
Authors: Verma Vandani
Published: July 2024

Pharmaceutical supply chains involve multiple stakeholders at various stages, beginning with the API source, moving on to the medication manufacturer, packaging and distribution firms, administrative regulators, hospitals, pharmacies, and finally the patient. Because of the difficulty in tracking and ensuring authenticity, counterfeit drugs are more likely to penetrate the distribution system. Increasing counterfeit medicinal products in the markets are putting a potential threat to pharmaceutical supply chain and to life of innocent people. There is a need of technology that could provide privacy, trust, transparency, security, authorization, and authentication to the clients and show proof of origin of products. Due to significant qualities such as decentralisation, transparency, a trust-free environment, anonymity, and immutability, blockchain-based drug traceability provides a viable answer to this problem. Blockchain technology provides an efficient and cost-effective option for improving various drug traceability functions and procedures to assure appropriate identification. There are many other ways that blockchain is being used in the pharmaceutical industry, including the packaging and supply chain functions. This paper describes the challenges in pharmaceutical supply chain and how the blockchain combined with pharmaceutical supply chain can be a problem solver. We also provide a blockchain architectures for product traceability in the pharmaceutical supply chain system.
Neutronic Analysis on Molten Salt Reactor (MSR) Using OpenMC Code With Variations of Geometry Core Fueled By LiF-BeF2-UF4
Authors: Syarifah Ratna Dewi , Putri Briyanti Adelia , Aji Indarta Kuncoro
Published: July 2024

Nuclear Power Plant can produce electricity more efficiently and have low carbon emissions. The nuclear reactor used in this study is the MSR (Molten Salt Reactor) FUJI-12. This study aims to conduct an analysis neutronics on MSR FUJI-12 by varying the geometry shape of the reactor core and finding the most effective geometry core to use in MSR. The material used in this study is a mixture of LiF-BeF2-UF4 molten salts. This study uses OpenMC code with nuclear data library ENDF/B VIII.1. The shapes of the geometry core that will be compared are, pancake, balance, and tall. The three geometry core shapes will then be varied into seven kinds. The results show that the geometry of the core is very influential on the reactivity of a nuclear reactor. The k_eff value for all geometry core variants at the beginning of the operating reactor is in a supercritical condition and it will be a critical or subcritical condition at the end of the reactor’s operating life. Balance and tall 1 variants have a high on distribution neutron flux and fission rate. The Balance variant also produces the smallest mass of plutonium nuclides. The neutronic analysis that has been carried out show that the balance variant is the optimal geometry core design that can be used on the MSR FUJI-12.
Effect of Annealing Parameters on Surface Roughness and Tensile Stress of 3D-Printed ABS Parts
Authors: Sudin Mohd Nizam
Published: July 2024

The primary objective of this research is to examine the effects of annealing temperature and duration on the surface quality and tensile strength of ABS-printed materials. ASTM 638 Type IV specimens were created in SolidWorks, sliced using Ultimaker Cura 4.4, and printed with a Creality Ender 3 3D printer using 1.75 mm ABS filament. The samples were subjected to thermal annealing at temperatures ranging from 120°C to 180°C. The annealing durations were set at 20, 40, and 60 minutes, after which the samples were cooled down to room temperature. The TR200 roughness tester and Instron 5585 tensile testing machine were utilized to measure surface roughness and tensile stress, respectively. The smoothest surface (0.622μm) was obtained when the temperature was set at 120°C for a duration of 20 minutes. On the other hand, the roughest surface (3.246μm) was observed when the temperature was increased to 180°C and maintained for a longer period of 60 minutes. The highest tensile stress of 75.681 MPa was observed at a temperature of 180°C for a duration of 60 minutes, indicating an optimal condition for maximizing the strength of ABS. However, there may be a limit, as suggested by previous research conducted at temperatures of 160°C and 180°C. In conclusion, it can be observed that the relationship between annealing temperature, duration, and surface roughness is not solely linear. The variations observed indicate the presence of interactions between these factors.
Optimization of Electro-Blown PVDF Nanofibrous Mats for Air Filter Applications
Authors: Toptaş Ali , Çalışır Mehmet , Kılıç Ali
Published: July 2024

Particles with diameters smaller than 2.5 µm (PM2.5) have the capability to penetrate respiratory system, thereby exerting adverse effects on human health. High-efficiency nanofiber mats present a viable and efficient solution for the purification of ambient air contaminated with such particulate matter. In this study, PVDF based electret nanofiber mats were optimized via electro-blowing technique. The experimental parameters were systematically devised utilizing a Taguchi three-level L9 orthogonal design, and the results were subsequently analyzed using ANOVA. In this context, among the examined parameters (concentration, air pressure, and electrical field), the most significant factors influencing fiber diameters were identified as concentration and electric field strength. While an increase in air pressure exhibited a negligible influence on fiber diameters, it was observed to mitigate undesired droplet density. The optimal parameters yielding the thinnest fiber (124 ± 71 nm) were determined as 9 wt.% concentration, 2 bar air pressure, and 30 kV electrical voltage. Furthermore, the application of corona discharge treatment to the specimens resulted in a remarkable enhancement of quality factors by over 70%.
Manufacturing Lead Time Using the Value Stream Mapping (VSM) Approach in the Oyster Mushroom Baglog Production Process
Authors: Islahudin Nur , Yusianto Rindra , Theo Jodanta Tegar
Published: July 2024

“Omah Mushroom Ungaran” is one of the oyster mushroom baglog producers in Indonesia. The problem is delays in fulfilling demand due to manufacturing lead time (MLT), which exceeds the time limit for the product to reach the customer. The MLT that appears to produce the average monthly demand is 6462 pcs baglog, which is 39575.73 minutes (28 days). We should fulfill the order for one month within 26 days. Therefore, the researchers created a design to improve the oyster mushroom baglog mixing process at the mixing workstation to reduce MLT. The approach taken is value stream mapping. The sieving process, which occurs after blending raw materials using a mixing machine, is causing delays in fulfilling demand and serves as the root cause. The mixing machine design used by the company has not been able to produce the desired mixing output. The solution the researchers designed was developing a mixing machine with a stirrer propeller. The researchers also created an infill tank on the device to unify the mixed packaging process. After implementing the improvements, results were obtained in the form of a reduction in sieving workstations, a reduction in non-added value (NVA) time, an increase in PCE by 3.68%, a decrease in MLT by 3213,718 minutes (2 days).
Synthesis and Characterization of Zinc Phthalocyanines Containing 2-Hydroxy-6-methoxyisonicotinic Acid Moieties
Authors: Akdemir Nesuhi , Yıldırım Aslı
Published: July 2024

Novel zinc phthalocyanines were synthesized by the reaction of phthalonitriles containing methyl 2-hydroxy-6-methoxyisonicotinate. These compounds were obtained via aromatic nucleophilic substitution reactions. All compounds have been determined by elemental analysis, FT-IR, NMR, MS and electronic absorption. The solubility of phthalocyanines is very low in DMSO and DMF but high in alkaline aqueous solution. The UV-Vis spectra of the Zn(II) phthalocyanines were recorded in different concentration in DMF, DMSO and also in different solvents as DMF, DMSO, water. Peripheral substitute zincphthalocyanines (5 and 7) showed aggregation in water. Nonperipheral substitute zincphthalocyanine (7) showed monomeric behavior in DMSO, DMF and water. Beer’s law was obeyed for zinc phthalocyanines.
Enhancing Transparency and Reproducibility in Finite Element Analysis through Comprehensive Reporting Parameters A Review
Authors: Haider Aun
Published: July 2024

Finite Element Analysis (FEA) serves as a valuable tool, offering an approximate resolution to partial differential equations, finding extensive utility in structural analysis and design. Intrinsic nature of approximation in FEA underscores the indispensability of meticulous documentation to inspire confidence in the derived outcomes. While comprehensive guidelines for model development abound, there exists a conspicuous absence of a standardized framework explicitly addressing reporting and communication facets of FE studies. Dearth of consistent documentation standards imparts a veneer of opacity to reported FE studies, hindering the requisite transparency essential for objective evaluation. In case, FE analyst remains oblivious to limitations inherent in FE model and simulation platform, reviewers and end-users consequently remain uninformed.
Evaluation and refinement of FE models can only be realized when a complete and coherent documentation of simulation studies is at hand. This paper endeavours to present pertinent reporting parameters crucial for a comprehensive understanding and reproducibility of FE studies. Encompassing aspects such as analysis description, model identification, structural modeling, discretization schemes, solver settings, and post-processing details, these reporting parameters aim to furnish a holistic view of simulation process. Furthermore, the manuscript explores realms of sensitivity analysis, verification, and validation (V & V) as indispensable components to fully establish predictive performance of FE models.
This paper concludes by advocating for the widespread dissemination of finite element models, affording prospective users the chance to scrutinize and improve upon these models. Illustrated through a case study involving an FE model of a wing rib, the presented reporting parameters establish a foundation for assessing overall quality and scientific rigour of simulation studies. They contribute to the establishment of accountability, reproducibility, and usability in the realm of FEA. Acknowledging dynamic nature of modeling and simulation techniques, these parameters are recognized as subject to evolution. Additionally, it is suggested that any supplementary parameters influencing accuracy of FE models should be duly incorporated for a more nuanced and exhaustive evaluation.
Exploring the Influence of Various Solvents on the Structural, Optical, and Spectroscopic Properties of MgO
Authors: Obaıd Kareem Rebaz , Ahmad Bast , Bulut Niyazi , Demirci Tuna , Ercan Ismail , Ercan Filiz , Ateş Tankut , Kaygılı Omer
Published: July 2024

Magnesium oxide (MgO) samples were manufactured at different temperatures using various solvents of water and ethanol. MgO structure was also modeled and its vibration modes were calculated. The kind of solvent as-used in the synthesis and calcination temperature caused changes in the lattice parameter, crystallinity, and crystallite size. The crystallite size increased with increasing production temperature for both series of the MgO. The morphology and bandgap energy were also affected significantly by the solvent and calcination temperature.
The Omniscient Divine Energy-Consciousness Paradigm: A Synthesis of Theology, Philosophy, and Modern Physics
Authors: Grasso Otangelo
Published: July 2024

This paper presents the Omniscient Divine Energy-Consciousness Paradigm (ODECP), an expanded framework that builds upon the Theocentric Energy-Consciousness Model. The ODECP attempts to synthesize concepts from theology, philosophy, and modern physics to provide a comprehensive view of reality.Key points of the ODECP include:1. Energy and consciousness are proposed as fundamental attributes of the divine, existing in a state of pure potential beyond spacetime.2. The physical universe is seen as an actualization or expression of this divine energy-consciousness.3. It posits a hierarchy of physical laws, with some being more fundamental than others.4. The paradigm suggests the possibility of multiple realms with different sets of physical laws.5. It proposes that divine energy-consciousness transcends time and entropy.The paper reviews fundamental laws of physics, particularly focusing on thermodynamics, and discusses how the ODECP relates to or challenges these established principles. It also explores the ontological necessity of energy laws and the relationship between energy and spacetime.The ODECP is presented as a potential solution to the theological problem of creation ex nihilo, suggesting that creation is more akin to an actualization of pre-existing divine potential rather than creation from nothing.The paper also includes a linguistic analysis of the Hebrew word "bereshit," drawing connections between its possible interpretations and the concepts proposed in the ODECP.Furthermore, the paper discusses the implications of this paradigm for scientific understanding, particularly in areas such as quantum mechanics, cosmology, and the nature of time. It also explores the philosophical implications, addressing topics like the mind-body problem, free will, and epistemology.The theological implications of the ODECP are examined, including its potential impact on understanding divine nature, creation, theodicy, and eschatology.Finally, the paper acknowledges potential challenges and criticisms of the ODECP, including issues of empirical verification and compatibility with established theories and theological doctrines.Overall, the paper presents the ODECP as a bold attempt to integrate theological, philosophical, and scientific understanding into a comprehensive framework, aiming to stimulate interdisciplinary dialogue and open new avenues for research and inquiry.
User Engagement and Wellbeing: The Role of Digital Self-Monitoring in Mental Health Support
Authors: Wang Yiyi , Kortschot Sean , Farb Norman A. S.
Published: July 2024

Growing global concerns around mental health require innovative and adaptive solutions. Technological support tools such as web applications provide an opportunity for such innovation, but even the most efficacious platform is limited by its ability to promote user engagement. This study explored the impact of user engagement in technology-supported self-monitoring for wellbeing in a cohort (N=196) of university undergraduate students. We aimed to identify an efficient measurement model for daily wellbeing, examining the impact of optimizing user-centered design to promote engagement and enhance user experience. To this end, participants were randomly assigned to either a passive control condition or to one of two daily self-reflection conditions. Self-reflection prompts were delivered using either an online questionnaire platform (Qualtrics), or an app designed specifically to engage users in wellbeing reflection (UpBeing). Results indicated that including general appraisal items alongside momentary affect assessment improved model fit compared to affect measurement alone. Furthermore, wellbeing-centered design (UpBeing) significantly enhanced self-reported wellbeing compared to both Qualtrics and the control conditions, accompanied by decreased negative mood and improved decentering skills. These findings suggest that app-based self-reflection tools like UpBeing can effectively support individuals’ wellbeing and coping abilities in daily life. Analysis of user experience reports suggested that the design of the UpBeing app likely contributed to its superior performance. Given that many apps only measure affect/mood without general appraisals of wellbeing, the study highlights the importance of validating measurements models in wellbeing support tools. While research into longitudinal and clinical outcomes is needed, implementing user-centered design in mental health support tools may be a promising method for enhancing health benefits through increased user engagement.
When Does the American Public Care About the...Economy? Re-Examining the Relationship Between Public Opinion on the Economy and the Environment
Authors: Fitz Erin B.
Published: July 2024

Extant literature suggests that a public more concerned with the economy will express less concern for the environment. Yet, this work largely fails to account for the potential endogeneity between environmental, economic, and other political factors; further, the economy-environment tradeoff hypothesis hinges on the assumption that the causal arrow between economic and environmental attitudes runs in a specific direction. I use vector autoregression (VAR) with Granger-causality tests to examine the potential relationships between macro level opinions on the environment, economy, and the president in the United States between 1960 and 2020. Contrary to the conventional economy-environment tradeoff hypothesis, I find that increases in public concern for the environment are associated with decreases in public confidence in the economy. These results add to evidence challenging previous assumptions surrounding economic attitudes by demonstrating that public opinion on the environment leads, rather than follows, public opinion on the economy.