bluuebunny/crossref_metadata_2025 huggingface dataset:
Mobile Mindfulness Meditation for Cancer-Related Anxiety and Neuropathy: Protocol for a Randomized Controlled Trial
Authors: Orasud Ariel Siritorn , Uchiyama Mai , Pagano Ian , Bantum Erin
Published: February 2024

Background

Anxiety- and cancer-related neuropathy are two persistent effects related to treatment for cancer. Mindfulness meditation has been used with substantial impact as a nonpharmacologic intervention to mitigate side and late effects of treatment. Mobile apps are ubiquitous for most of the general population, yet have a particular relevance for cancer survivors, given that physical and geographic limitations can be present.

Objective

This study aims to describe an ongoing trial of the Mindfulness Coach mobile app for cancer survivors.

Methods

In this randomized waitlist controlled trial, cancer survivors experiencing anxiety- or cancer-related neuropathy (200 for neuropathy and 200 for anxiety) and who had finished primary cancer treatment were invited to participate. Data were collected at 3 time points regardless of randomization condition: baseline, 8 weeks, and 16 weeks. Both face-to-face and web-based recruitment strategies were used. The trial was opened for 2 separate primary outcomes (anxiety- or cancer-related neuropathy). The goal was not to compare these groups but to compare treatment and waitlist groups for each condition. In addition to evaluating the impact of mobile mindfulness on reported anxiety- or cancer-related neuropathy, other pain, fatigue, trauma, sleep, and satisfaction with the Mindfulness Coach app will also be assessed.

Results

Outcomes of the study are expected in early 2024.

Conclusions

Mindfulness meditation has become widely practiced, and the use of mobile technology has become ubiquitous. Finding ways to deliver mindfulness meditation to people who have been treated for cancer allows for the intervention to be accessible to a larger number of survivors. The results of this intervention could have implications for further understanding the impact of mindfulness meditation on 2 persistent side and late effects of treatment of cancer, namely anxiety- and cancer-related neuropathy.

Trial Registration

ClinicalTrials.gov NCT03581357; https://ClinicalTrials.gov/study/NCT03581357

International Registered Report Identifier (IRRID)

DERR1-10.2196/47745
Exploration of Art Curriculum Teaching in Universities from the Perspective of Bashu Culture
Authors: Lina Guo
Published: February 2024

It is necessary to integrate regional cultural characteristics into school art courses. This article explores the university art curriculum system under the visual perspective of Bashu culture. Elaborate on the three-dimensional objectives, course content, design principles, and evaluation models of the course, and inherit regional culture through new educational methods to enhance the confidence of college students in ethnic culture. Explore the design of art courses with regional culture, stimulate students’ creative thinking, and enable them to flexibly use various expressions in the process of deepening their understanding of art to permanently inherit China’s unique regional culture and art.
РАЗВИТИЕ ОТЕЧЕСТВЕННЫХ САПР ПРОЕКТИРОВАНИЯ МИКРОЭЛЕКТРОНИКИ НА ПЛАТФОРМЕ DELTA DESIGN
Authors: Малышев Н.
Published: February 2024

Уход с российского рынка крупных международных игроков в области
проектирования радиоэлектроники стал большим толчком к развитию
и узнаваемости отечественных систем. САПР Delta Design российской
компании «ЭРЕМЕКС» уже больше 10 лет присутствовала на рынке и давала
возможность «бесшовного» перехода с продуктов компаний Altium и Mentor
Graphics при разработке печатных плат без потери функциональности.
Кроме того, в пакете предусмотрены собственные уникальные
конкурентные решения для моделирования и трассировки. На платформе
Delta Design разрабатывались также инструменты, на основе которых
появились продукты DeltaCAM [1], SimOne [2], Delta Design Simtera [3],
Delta Design Simtera IC. В статье рассмотрено развитие последнего продукта
из этого списка – программного пакета Delta Design Simtera IC.
СКАНИРУЮЩАЯ ЗОНДОВАЯ МИКРОСКОПИЯ SUBSTANTIA NIGRA
Authors: Ахметова А.И. , Советников Т.О. , Зорикова Е.О. , Яминский И.В.
Published: February 2024

Реакция клеток на механические сигналы играет ключевую роль в жизненно важных биологических процессах, таких как развитие органов, регенерация тканей, старение и развитие рака. Механические свойства, такие как упругость, мягкость, шероховатость, вязкость, показывают, как клетки и ткани реагируют на воздействие и как от этого зависят их биологические функции. Сканирующая зондовая микроскопия (СЗМ) является универсальным инструментом для количественной характеристики механических свойств тканей и клеток в естественных условиях. Данные о механических свойствах биологических объектов, полученные с помощью атомно-силовой и капиллярной микроскопии, могут быть связаны с биологическими процессами и патологиями в тканях.
ВЗАИМОСВЯЗЬ СВОЙСТВ И СТЕПЕНИ ДИСПЕРСИИ НАНОНАПОЛНИТЕЛЯ ДЛЯ НАНОКОМПОЗИТОВ ПОЛИМЕР/УГЛЕРОДНЫЕ НАНОТРУБКИ
Authors: Алтуханова Л.Б. , Долбин И.В.
Published: February 2024

В настоящей работе введен параметр степени дисперсии нанонаполнителя, количественно характеризующий уровень дисперсии последнего в нанокомпозитах полимер/углеродные нанотрубки. Этот параметр является функцией размера агрегатов нанонаполнителя и его содержания. Показана взаимосвязь уровня дисперсии нанонаполнителя и степени усиления, что дает возможность прогнозирования свойств рассматриваемых нанокомпозитов.
Recintos y ajuar eclesiástico entre Chiapas y Guatemala
Authors: Vences Vidal María Magdalena
Published: February 2024

El libro que el lector tiene en sus manos guarda su origen en la Semana Santa del año 2011. Durante unas dos décadas me dediqué a recorrer —por lo general acompañado de mi mujer, Graciela Alcalá, y en ocasiones del arqueólogo Thomas Lee— el territorio de la antigua provincia de Chiapas para conocer de cerca los pueblos de indios del periodo colonial como una parte fundamental de mis investigaciones sobre geografía histórica de aquella jurisdicción. En estos viajes descubrí muchas de las bellezas que esconde el estado de Chiapas, entre otras los pueblos que quedaron deshabitados como resultado de las epidemias que asolaron aquella región (particularmente en sus tierras calientes), y en los que permanecen restos más o menos completos de sus magníficas iglesias y conventos.
Revistas, blogs y portales latinoamericanos (1960-2020) Rupturas y transformaciones en el tránsito de lo impreso a lo digital
Authors: Crespo Franzoni Regina , Guerra González Jenny Teresita , Petra Adriana Carmen , Maiz Claudio , Quaresma Valentina , Fonseca Claudia Lorena , Ferreira da Silva Júnior José Antonio , Ayo Schmiedecke Natália , Janz Woitowicz Karina , Juárez Vázquez Gerardo , Rubio Escobar Ana Gabriela , Vigna Diego
Published: February 2024

En América Latina, las revistas han sido un espacio clave para la acción político-cultural de grupos de intelectuales, artistas y escritores, especialmente en momentos de inestabilidad y crisis política. Así ocurrió en las décadas de 1960 y 1970, en los países del Cono Sur, cuando las revistas político-culturales cumplieron un papel fundamental de baluartes de resistencia, explícitos o camuflados, a los regímenes dictatoriales. En los años 1960, 70 y 80, en Centroamérica, algunas publicaciones tuvieron un rol importante en los conflictos políticos, como vehículos de difusión y propaganda de los movimientos en contienda. A partir de 1980, con los procesos de redemocratización en Sudamérica, muchas publicaciones llevaron a cabo una agenda de discusión de la política continental y del nuevo papel de los movimientos de izquierda.
OPTIMIZING THE USE OF AUTHENTIC MATERIALS IN THE WORD FORMATION PROCESS TO IMPROVE STUDENTS’ UNDERSTANDING IN THE ENGLISH MORPHOLOGY SUBJECT
Authors: Adha Annisha Dyuli , Gusta Wienda , Afersa Mona
Published: February 2024

The purposes of this research are to (1) determine students' abilities in using word formation by using authentic materials provided. The instrument used to determine the student's abilities is MAT (Morphological Awareness Test); and (2) to determine the type and process of word formation contained in the authentic materials. This study used descriptive qualitative method. The results of this research, based on the MAT used, showed that the students’ understanding towards word formation process increased with the mean score was 83,26.  Meanwhile, the types of word formation found in the authentic materials were compounding, derivation, inflection, conversion, abbreviation, back formation, and initialism.
Fire Resilience in Buildings - A Qualitative Overview
Authors: Pathan Mr. Sadam , Payghan Prof. V. R. , Bhirud Dr. A. N.
Published: February 2024

Abstract: Fire resilience in buildings is a necessity of the current decade. The fire safety for the buildings in India has to be assessed in qualitative as well as quantitative approaches. The on-site inspection may not be fruitful as the inspection might not be able to depict the exact picture of the Fire Safety Situation of the building. The integration of the Multi Criteria Decision Making system in compliance with Technical, Organizational, Social, and Economic as well as with the correlation of Redundancy, Robustness, and Resourcefulness the accuracy of assessment and prevention of causality at the time of incident gets reduced
Selection of Diabetic Retinopathy and Applying Optimal Classifiers
Authors: Kumari Sarita , Upadhaya Dr. Amrita
Published: February 2024

Abstract: Diabetic retinopathy (DR), often known as DR, is a common consequence of diabetes that frequently results in permanent vision loss if it is not recognized and treated in its early stages. By concentrating on this election of suitable classifiers for the analysis of retinal pictures, the purpose of this research study is to make a contribution to the enhancement of DR detection. The major goal is to improve the accuracy, efficiency, and scalability of the procedures involved in DR screening. Collecting and preprocessing a broad dataset of retinal pictures, each of which is tagged with the severity of diabetic retinopathy, is the first step in the study process. Following this, a number of different machine learning and deep learning classifiers are assessed in order to determine which model is the most effective at recognizing minor indicators of DR. The classification methods that are being taken into consideration are as follows: logistic regression, support vector machines, random forests, decision trees, and convolution neural networks. The process of assessment includes intensive testing on the training dataset and the validation dataset, as well as the extraction of features and the tuning of hyper parameters. A later deployment of the optimum classifier that was chosen for use in real-world applications is carried out, with an emphasis placed on its incorporation into healthcare systems for the purpose of streamlining DR tests. The study addresses the need for early detection, scalability, and resource optimization in healthcare settings. The goal of their search is to develop a solution that is both accessible and cost-effective for diabetes patients. Additionally, the study investigates the possibility of customized healthcare by teaching classifiers to detect unique patterns in retinal pictures, which ultimately results in an improvement in diagnostic accuracy. The research also investigates the influence that optimal classifiers have on public health, taking into consideration the possibility of a decrease in theprevalenceofvisualimpairmentthatisconnectedwithdiabeticretinopathy
Smart Voting Web Based Application Using Aadhar
Authors: . Lokesh
Published: February 2024

Abstract: Elections are a crucial part of any democratic system, and it is essential to ensure that the voting process is conducted in a fair and transparent manner. In traditional paper-based elections, the process is time-consuming, resource-intensive, and prone to errors. In this context, the use of technology can significantly improve the efficiency, security, and accuracy of the voting process. In this project, we propose an online voting system that uses face recognition technology to identify and authenticate voters. The proposed system allows voters to cast their votes remotely, eliminating the need for physical ballot boxes and reducing the cost and time involved in the voting process. The system works by capturing the facial image of the voter and passing it to the server unit for verification. The server compares the facial image with the information stored in the database and verifies the identity of the voter. If the identity is verified, the voter is allowed to cast the vote; otherwise, an error message is displayed on the screen, and the person is not allowed to poll the vote. The system is designed to be secure and tamper-proof. The use of face recognition technology makes it difficult for anyone to impersonate another person and cast a fraudulent vote. The system also ensures that each voter can cast only one vote, and the voting process is conducted in a transparent and fair manner. Overall, the proposed online voting system offers numerous advantages over traditional paper-based voting systems, including increased efficiency, reduced cost, improved security, and transparency.
Incompatibility of quantum instruments
Authors: Leppäjärvi Leevi , Sedlák Michal
Published: February 2024

Quantum instruments describe outcome probability as well as state change induced by measurement of a quantum system. Incompatibility of two instruments, i. e. the impossibility to realize them simultaneously on a given quantum system, generalizes incompatibility of channels and incompatibility of positive operator-valued measures (POVMs). We derive implications of instrument compatibility for the induced POVMs and channels. We also study relation of instrument compatibility to the concept of non-disturbance. Finally, we prove equivalence between instrument compatibility and postprocessing of certain instruments, which we term complementary instruments. We illustrate our findings on examples of various classes of instruments.
Gravitational quantum switch on a superposition of spherical shells
Authors: S. Móller Natália , Sahdo Bruna , Yokomizo Nelson
Published: February 2024

In the absence of a complete theory of quantum gravity, phenomenological models built upon minimal assumptions have been explored for the analysis of possible quantum effects in gravitational systems. Implications of a superposition of geometries have been considered in such models, including the occurrence of processes with indefinite order. In a gravitational quantum switch, in particular, the order of operations applied by two agents on a target system is entangled with the state of the geometry. We consider a model describing the superposition of geometries produced by distinct arrangements of spherical mass shells, and show that a protocol for the implementation of a gravitational quantum switch can be formulated in such a system. The geometries in superposition are identical in an exterior region outside a given radius, and differ within such a radius. The exterior region provides a classical frame from which the superposition of geometries in the interior region can be probed. One of the agents crosses the interior region and becomes entangled with the geometry, which is explored as a resource for the implementation of the quantum switch. Novel features of the protocol include the superposition of nonisometric geometries, the existence of a region with a definite geometry, and the fact that the agent that experiences the superposition of geometries is in free fall, preventing information on the global geometry to be obtained from within its laboratory.
Stabilizer Codes with Exotic Local-dimensions
Authors: Gunderman Lane G.
Published: February 2024

Traditional stabilizer codes operate over prime power local-dimensions. In this work we extend the stabilizer formalism using the local-dimension-invariant setting to import stabilizer codes from these standard local-dimensions to other cases. In particular, we show that any traditional stabilizer code can be used for analog continuous-variable codes, and consider restrictions in phase space and discretized phase space. This puts this framework on an equivalent footing as traditional stabilizer codes. Following this, using extensions of prior ideas, we show that a stabilizer code originally designed with a finite field local-dimension can be transformed into a code with the same n, k, and d parameters for any integral domain. This is of theoretical interest and can be of use for systems whose local-dimension is better described by mathematical rings, which permits the use of traditional stabilizer codes for protecting their information as well.
Perlawanan Bangsa Palestina Dalam Lagu Zalzil Amna Israel Karya Grup Nashid Fariq Wa’d ( Kajian Semiotika Charles Sander Pierce )
Authors: Siregar Saputra Husein , Fahriany
Published: February 2024

This research is titled Resistance in the song Zalzil Amna Israel by Nashid Wa'd group, in the song Zalzil there are symbols of resistance that are called to the Palestinian people to the Israeli Zionist Occupiers, so, in this case, the author seeks to explain where the symbols of the signs that exist in the lyrics of the song Zalzil which shows the aesthetic resistance to Israel, by using Charles Sander Pierce's analytical knife as a means of dissecting the Zalzil song to find the meaning or sign of resistance in the lyrics of the Zalzil song, with the Triadic Concept or Charles Sander Pierce's triangle sign, namely: Representamen, Object, Intepretan. In simplifying the author uses descriptive analysis to identify the meaning of resistance in the lyrics.

 

Penelitian ini berjudul Perlawanan dalam lagu Zalzil Amna Israel karya grup Nashid Wa’d, dalam lagu zalzil tersebut terdapat simbol tentang perlawanan yang di serukan kepada rakyat Palestina kepada para Penjajah Zionis Israel, maka dalam hal ini penulis berupaya menjelaskan dimana simbol-simbol tanda yang ada dalam lirik lagu Zalzil yang menunjukkan pada estetis perlawanan Kepada Israel, dengan menggunakan pisau analisanya Charles Sander Pierce sebagai sarana dalam membedah Lagu zalzil mencari makna atau tanda Perlawanan pada lirik Lagu Zalzil tersebut, dengan Konsep Triadic atau segitiga tandanya Charles sander Pierce yakni : Representamen, Objek, Intepretan. Dalam mempermudah penulis menggunakan analisis deskriptif untuk mengidentifikasi makna Perlawan dalam Lirik Tersebut
El Régimen de Zonas Francas y la defamilización de los cuidados en Costa Rica
Authors: Jiménez Montero Daniela , Sánchez Arias Claribel
Published: February 2024

Frente a la urgencia de políticas para la defamilización del cuidado y su financiamiento, este trabajo pretende aglutinar elementos teóricos que demuestren la pertinencia de revisar las exenciones fiscales del Régimen de Zona Franca (RZF) en Costa Rica, en dirección hacia la responsabilidad de las empresas adscritas a este régimen en materia de cuidados, mediante una metodología cualitativa con estrategia de revisión documental y enfoque teórico-exploratorio. Se demuestra la necesidad de revisar los regímenes de exención fiscal del RZF con el objetivo de fortalecer los procesos de defamilización de los cuidados en la sociedad costarricense y contribuir con el mejoramiento de las condiciones y oportunidades laborales de las mujeres.
Hilos del pasado: herramientas metodológicas para reconstruir la memoria colectiva de organizaciones campesinas. Casos UPANACIONAL y UPIAV
Authors: García Fonseca Tanya
Published: February 2024

El propósito de este artículo es brindar recomendaciones metodológicas para la reconstrucción de la memoria colectiva en organizaciones sociales, esto permite comprender la historia y la identidad de estas organizaciones, preservando su legado y fortaleciendo su representatividad. La investigación en la que se basa este artículo se llevó a cabo en colaboración con sindicatos campesinos en Costa Rica, utilizando un enfoque mixto. Entre las recomendaciones clave están cultivar confianza y empatía con las personas participantes, mantener registros reflexivos para enriquecer la comprensión del fenómeno social y facilitar la replicación de la metodología. Además, es crucial mantener un equilibrio entre flexibilidad y rigurosidad para garantizar la adaptabilidad a diferentes contextos y permitir la extrapolación de la metodología a grupos similares, facilitando así la generación de información comparable.
Aportes del Colegio Técnico Profesional de Calle Zamora a los Objetivos de Desarrollo Sostenible en una comunidad
Authors: Montero Salas Marianela , Guido Granados Ismael
Published: February 2024

Se describen los aportes que brindan los centros educativos en zonas rurales a la sostenibilidad. La investigación, se realizó en la comunidad de Calle Zamora, San Ramón, Costa Rica, mediante entrevistas a 120 vecinos del lugar y encuestas a dueños de comercios, para determinar aspectos socioeconómicos y ambientales que han mejorado desde la creación del Colegio Técnico Profesional de Calle Zamora (CTPCZ) en esta comunidad rural. Se analizaron los resultados tomando en cuenta las metas de los objetivos del Desarrollo Sostenible de la agenda 2030.
Aportes del Programa de Posgrado en Desarrollo Sostenible de la Universidad de Costa Rica (2007–2023)
Authors: Guido Granados Ismael , Alvarez Rivera Katherine , Cordón Ramírez Víctor Mauricio , Javier Montoya Rojas Francisco , Moya Calderón Michael
Published: February 2024

Este estudio indaga la relación y contribución de las investigaciones del Programa de Posgrado en Desarrollo Sostenible de la Universidad de Costa Rica al desarrollo sostenible. Se examinaron 46 tesis desarrolladas en el período entre 2007 y 2023. Mediante un análisis documental minucioso, se investigaron aspectos como la autoría, género, nacionalidad, énfasis, así como las ubicaciones y objetos de estudio de cada investigación. Este análisis permitió la identificación de tres categorías de enfoque: 1) comunidades locales, 2) organizaciones y 3) áreas protegidas. Por último, se analizó el enfoque de las investigaciones en temas como la pobreza, hambre, salud, educación, trabajo digno, producción y consumo responsables, alianzas y preservación de ecosistemas terrestres. Este análisis posibilitó el establecimiento de conexiones directas con los Objetivos de Desarrollo Sostenible.
A semiotic perspective of mathematical activity: The case of integer
Authors: Purwasih Ratni , Turmudi Turmudi , Afgani Dahlan Jarnawi , Irawan Edi , Minasyan Sona
Published: February 2024

Semiotics is defined as using signs to represent mathematical concepts in problem-solving. The mathematical semiotic process involves creating meaning from the triadic relationship between the representamen (R), object (O), and interpretant (I). Mathematical semiotics play an essential role in the cognitive processes of individuals as they formulate and communicate mathematical ideas. Therefore, this study aims to describe the stages of the semiotic process of junior high school students solving integers-related mathematical problems. In this qualitative analysis, the participant is a seventh-grade student categorized as pseudo-semiotic. The research instrument is a test on integers and interviews. The results demonstrate that the semiosis related to integers involves the representamen, object, and interpretant stages. For a subject with a pseudo-semiotic type, this meaning-making process requires the construction of a comprehensive understanding of the concept. Furthermore, the understanding is developed using various instruments, resulting in connection conflicts between different components of the semiotic system. Connection conflict occurs because of the mismatched relationship between the elements of semiosis: representamen, object, and interpretant. A pseudo-semiotic subject only has a superficial understanding of mathematical concepts, making it challenging to establish accurate connections between symbols and their underlying meanings. Consequently, this hinders the ability to understand mathematics profoundly and apply the concepts in real-life situations.
Reservoir drawdown highlights the emergent effects of water level change on reservoir physics, chemistry, and biology
Authors: Lewis Abigail S. L. , Breef-Pilz Adrienne , Howard Dexter , Lofton Mary E , Olsson Freya , Wander Heather L. , Wood Cecelia E. , Schreiber Madeline , Carey Cayelan
Published: February 2024

Water level drawdowns are increasingly common in lakes and reservoirs
worldwide as a result of both climate change and water management.
Drawdowns can have direct effects on physical properties of a waterbody
(e.g., by altering stratification and light dynamics), which can
interact to modify the waterbody’s biology and chemistry. However, the
ecosystem-level effects of drawdown remain poorly characterized in
small, thermally-stratified reservoirs, which are common in many regions
of the world. Here, we intensively monitored a small eutrophic reservoir
for two years, including before, during, and after a month-long drawdown
that reduced total reservoir volume by 36%. During drawdown,
stratification strength (maximum buoyancy frequency) and surface
phosphate concentrations both increased, contributing to a substantial
surface phytoplankton bloom. The peak in phytoplankton biomass was
followed by cascading changes in surface water chemistry associated with
bloom degradation, with sequential peaks in dissolved organic carbon,
dissolved carbon dioxide, and ammonium concentrations that were up to an
order of magnitude higher than the previous year. Dissolved oxygen
concentrations substantially decreased in the surface waters during
drawdown (to 41% saturation), which was associated with increased total
iron and manganese concentrations. Combined, our results illustrate how
changes in water level can have cascading effects on coupled physical,
chemical, and biological processes. As climate change and water
management continue to increase the frequency of drawdowns in lakes
worldwide, our results highlight the importance of characterizing how
water level variability can alter complex in-lake ecosystem processes,
thereby affecting water quality.
Economic, geographical, institutional, and political determinants of bilateral manufacturing exports: A structural gravity model approach for Türkiye
Authors: Akça Emrah
Published: February 2024

The study investigates the economic, geographical, institutional, and
political determinants of T?rkiye?s bilateral manufacturing exports for
2003-2018, applying the structural gravity model and considering 30 main
export partners of T?rkiye. The Poisson pseudo maximum likelihood method
results reveal that T?rkiye?s manufacturing exports are mostly directed by
its own and partners? economic sizes. While common borders and cultural
similarity positively impact manufacturing exports, distance and landlocked
position affect it negatively. The degrees of institutional quality, trade
freedom in T?rkiye, and membership of the partner countries in the World
Trade Organization are resistance factors against manufacturing exports,
whereas trade agreements encourage it. As the bilateral or multilateral
trade agreements turned out to be the driving forces of manufacturing
exports, T?rkiye should sign additional trade agreements and/or amplify
trade agreements that have already been signed rather than standard trade
policy implementations.
Relationship of Fat Mass Ratio, a Biomarker for Lipodystrophy, With Cardiometabolic Traits
Authors: Agrawal Saaket , Luan Jian’an , Cummings Beryl B. , Weiss Ethan J. , Wareham Nick J. , Khera Amit V.
Published: February 2024

Familial partial lipodystrophy (FPLD) is a heterogenous group of syndromes associated with a high prevalence of cardiometabolic diseases. Prior work has proposed DEXA-derived fat mass ratio (FMR), defined as trunk fat percentage divided by leg fat percentage, as a biomarker of FPLD, but this metric has not previously been characterized in large cohort studies. We set out to 1) understand the cardiometabolic burden of individuals with high FMR in up to 40,796 participants in the UK Biobank and 9,408 participants in the Fenland study, 2) characterize the common variant genetic underpinnings of FMR, and 3) build and test a polygenic predictor for FMR. Participants with high FMR were at higher risk for type 2 diabetes (odds ratio [OR] 2.30, P = 3.5 × 10−41) and metabolic dysfunction–associated liver disease or steatohepatitis (OR 2.55, P = 4.9 × 10−7) in UK Biobank and had higher fasting insulin (difference 19.8 pmol/L, P = 5.7 × 10−36) and fasting triglycerides (difference 36.1 mg/dL, P = 2.5 × 10−28) in the Fenland study. Across FMR and its component traits, 61 conditionally independent variant-trait pairs were discovered, including 13 newly identified pairs. A polygenic score for FMR was associated with an increased risk of cardiometabolic diseases. This work establishes the cardiometabolic significance of high FMR, a biomarker for FPLD, in two large cohort studies and may prove useful in increasing diagnosis rates of patients with metabolically unhealthy fat distribution to enable treatment or a preventive therapy.

Article Highlights
Early medieval burial from the culmination of the Old Town Hill in Sandomierz
Authors: Florek Marek , Szczepanek Anita
Published: February 2024

The subject of this article is a grave dated to the end of the 10th c. AD discovered in 2016 at the culmination of the so-called Old Town Hill in Sandomierz. The grave, just like a burial found in 2006 – located a dozen or so metres from the discussed feature – was unusually oriented – approximately along the N-S axis. Specialist analyses and examination of the burial goods found in the grave – a knife, a firesteel, a flint strike-a-light and a vessel fragment – indicate that the buried man probably lived in Sandomierz or its surroundings. The graves discovered in 2006 and 2016 are not part of a vast cemetery that occupied the middle and upper part of the Old Town Hill in the 11th c., but they are separate burials. It is possible that they attest to an abandoned attempt to establish a cemetery by an unspecified group inhabiting Sandomierz at the end of the 11th c., desiring to stress their distinctiveness from the rest of the population not only by having their own necropolis, but also by digging graves that were oriented in a different direction.
In the middle of nowhere. Unique sword scabbard chape from Niepołomice Forest
Authors: Janowski Andrzej , Sojka Krzysztof , Włodarczak Ewa
Published: February 2024

Detector recognition carried out in Lesser Poland in last few years deliver a wealth of movable historical artefacts. One of them is a sword scabbard chape made of a copper alloy discovered in the middle of Niepołomice Forest. The paper subjected this artefact to typological classifications, comparative analysis, dating and ethnocultural characterization. Sword scabbard chapes in this type are very rare finds and most of them were discovered in southern and eastern Europe in Bulgaria, Ungarn and Ukraine, and are dated to the second half of the 10th and the 11th century. Specimen from Niepołomice Forest was presumably created in one of these areas and ended up here via one of the trade routes that intersected in Cracow.
Early Neolithic red-painted pottery from the Prandocin site, southern Poland. Indirect transfer in a technological context
Authors: Rauba-Bukowska Anna , Nowak Maciej , Jużwińska Gabriela , Moskal-del Hoyo Magdalena
Published: February 2024

The paper presents the results of specialized research on a small collection of artefacts of the Linear Pottery Culture in southern Poland. Among the 27 pottery fragments discovered at the Prandocin Site 1, a few painted fragments were identified. Such kind of painting style directly relates to the Želiezovce group of this culture in western Slovakia. Painted vessels are rarely found in the context of the Linear Pottery Culture in Lesser Poland (Małopolska), which is why special attention was given to raw material and technological studies of the ceramics. The study aimed to answer the question of whether the painted vessel was produced locally or if it representsevidence of direct migration of people, objects, or ideas from the areas of present-day western Slovakia at the turn of the 6th and 5th millennium BC.
Innovative Treatment Strategy for Cancer with Nanotechnology: A Review
Authors: Bachhav Rushikesh
Published: February 2024

By reducing collateral toxicity to nonmalignant cells, nanotechnology has the potential to improve the efficacy and selectivity of chemical, physical, and biological methods for inducing cancer cell death. More and more materials at the nanoscale are being actively and passively targeted to specifically target cancer cells. This review focuses on how different tactics with distinct identifying qualities set nanoparticles apart from earlier anticancer medicines in terms of their capacity to recognize cells. Additionally, it talks about how precise medication delivery via nanoparticles inside the cells has been the subject of numerous successful studies, as well as how nanoparticles can be used to treat cancer specifically while removing the side effects of conventional medicines.
Nanophytomedicine: Bridging the Gap between Nanotechnology and Herbal Therapeutics
Authors: Vinayak kadam Vrushali
Published: February 2024

In the dynamic landscape of medical research, a groundbreaking convergence has emerged, promising to reshape the future of healthcare—Nanophytomedicine. This innovative field represents the fusion of two seemingly distinct domains: nanotechnology, with its microscopic precision, and herbal therapeutics, rooted in traditional healing practices. The title, “Nanophytomedicine: Bridging the Gap between Nanotechnology and Herbal Therapeutics,” encapsulates the essence of this transformative intersection
Pengaruh Pelatihan Dan Pengawasan Terhadap Kinerja Mitra Statistik Pada Badan Pusat Statistik Kabupaten Buleleng
Authors: Kadek Sri Asih  , Mayasari Ni Made Dwi Ariani
Published: February 2024

The performance of statistical partners has not met the desired standard. The performance of these partners can be assessed by evaluating their ability to meet work targets. This study aims to explore the impact of coaching and supervision both independently and jointly on the performance of statistical partners at BPS Buleleng Regency. The research design used for this research is quantitative with a causal approach. The research population is all statistical partners who work in Buleleng Regency, a total of 260 people. The sampleqfor thisqstudy was selected using purposive sampling, and consisted of 50 participants. Research data were collected through the use of questionnaires andqanalyzed using multiple linear regression analysis. The results showed that (1) training and supervision had a significant effect on the performance of BPS statistical partners in Buleleng Regency, (2) training had a positiveqand significant effect on the performanceqofqstatistical partners in BPS Buleleng Regency, and (3) supervision had aqpositive and significant effect on the performance of statistical partners in BPS Buleleng Regency. Significant effect onqthe performanceqof statistical partners at BPS Buleleng Regency
Pengaruh Brand Image dan Influencer Marketing terhadap Keputusan Pembelian Produk Scarlett Whithening di Toko Kosmetik Beauty Shop Seririt
Authors: Ayu Ade Wahyu Krisna Yani Ayu Ade , Yulianthini Ni Nyoman
Published: February 2024

The objective of this research is to investigate the influence of (1) brand image and influencer marketing on purchasing decisions, (2) brand image on purchasing decisions, and (3) influencer marketing on purchasing decisions for Scarlett whitening products at the Beauty Shop Seririt cosmetics store. The employed methodology is characterized by a quantitative approach with a causal research design. The focus of the study pertains to the examination of the relationship between brand image and influencer marketing as independent variables and their impact on purchasing decisions as the dependent variable. The study's participants consisted of 100 individuals who were consumers of Scarlett whitening products. The information was collected by administering a questionnaire and then analyzed using various methods of multiple linear regression. The findings of the research indicate that: (1) The impact of brand image and influencer marketing on consumer purchasing decisions is noteworthy. (2) The impact of brand image on consumer purchasing behavior is both substantial and favorable. (3) The utilization of influencer marketing has been found to have a noteworthy and favorable impact on consumer purchasing behavior
Pengaruh Motivasi Kerja Dan Etos Kerja Terhadap Kinerja Karyawan Non Asn Di Lingkungan Kantor Dinas Pendidikan Pemuda Dan Olahraga Kabupaten Buleleng
Authors: I Made Sura Ananda  , Suci Ni Made
Published: February 2024

This study aims to examine the effect of work motivation and work ethic simultaneously or partially on the performance of non-ASN employees in the Buleleng Regency youth and sports education office. The research design used in this study is causal quantitative. This study used saturated sample with 50 respondents. The instrument used in data collection was a questionnaire and the analysis technique used was multiple linear regression analysis. The results of this study are (1) work motivation has a positive and significant effect on the performance of non ASN employees in the Disdikpora Buleleng, (2) work ethic has a positive and insignificant effect on the performance of non ASN employees in the Disdikpora Buleleng office environment, and (3) ) work motivation and work ethic have a significant effect on the performance of non-ASN employees in the Disdikpora Buleleng
Pengaruh Kompetensi Sosial Dan Motivasi Kerja Terhadap Kinerja Pegawai Di Dinas Perumahan, Kawasan Permukiman Dan Pertanahan Kabupaten Buleleng
Authors: Pradhana I Made Aswin , Trianasari  , Suarmanayasa I Nengah
Published: February 2024

The purpose of this study was to determine (1) the impact of social competence on employee performance at the Department of Housing, Settlement, and Land Affairs of Buleleng Regency, (2) the impact of social competence on employee performance through employee motivation at the Department of Housing, Settlement, and Land Affairs of Buleleng Regency, and (3) the impact of employee motivation on employee performance at the Department of Housing, Settlement, and Land Affairs of Buleleng Regency. This study utilized a quantitative causal design. The subjects of this study were all contract employees at the Department of Housing, Settlement, and Land Affairs of Buleleng Regency. The results of this study indicate that: (1) social competence has a positive and significant impact on employee performance at the Department of Housing, Settlement, and Land Affairs of Buleleng Regency, (2) social competence has a positive and significant impact on employee performance through employee motivation at the Department of Housing, Settlement, and Land Affairs of Buleleng Regency, and (3) employee motivation has a positive and significant impact on employee performance at the Department of Housing, Settlement, and Land Affairs of Buleleng Regency.
Peran Citra Destinasi Berkearifan Lokal Memediasi Atribut Destinasi dan Kualitas Layanan Terhadap Niat Berkunjung Kembali
Authors: Suandari Ni Putu Khrisnia , Yasa Ni Nyoman Kerti , Sukaatmadja I Putu Gde
Published: February 2024

The aim of this research is to explain the role of destination image with local wisdom in mediating the influence of destination attributes and service quality on intention to return to tourist villages in Buleleng Regency. The population of this research is domestic tourists who have visited tourist villages in Buleleng Regency. The sample size used was 115 domestic tourists using a purposive sampling method. The analysis technique used is Path Analysis using SEM-PLS. The research results show that destination attributes have a positive and significant effect on the image of a destination with local wisdom and intention to visit again. Service quality has a positive and significant effect on the image of a destination with local wisdom and intention to visit again. Likewise, the image of a destination with local wisdom has a positive and significant effect on intention to visit again. Furthermore, destination image with local wisdom is able to partially mediate the influence of destination attributes and service quality on intention to revisit.
Inovasi Pembelajaran Oleh Guru Di Jember Pada Masa Pandemi Covid 19
Authors: Tiara Tiara , Herlindawati Dwi , Kantun Sri
Published: February 2024

This study aims to analyze teacher innovation in learning in the era of the co-19 pandemic. The research method uses qualitative research with a phenomenological approach. The research was conducted in Jember district with an economics teacher at the high school level as the subject. The data presented in this study is in the form of an overview of learning innovations carried out by teachers during the Covid-19 pandemic seen from six dimensions: (1) learning objectives, (2) teacher’s role (s) (3) students' role(s), (4) ICT used, (5) connectedness, and (6) multiplicity of learning outcomes exhibited. The results of the research show that the learning objectives dimension is in the some new elements level category, the teacher's role dimension in the learning process is in the emergent level category, the student's role dimension in the learning process is in the some new elements level category, the ICT dimension used in learning effectiveness and learning was found to be in the emergent level category, the connectedness dimension of the learning process was found to be in the some new elements level category, the diversity dimension of evaluation of learning results used by teachers was in the some new elements level category.
Pengaruh Leader-Member Exchange dan Motivasi pada Organizational Citizenship Behavior dengan Kepuasan Kerja sebagai Pemediasi
Authors: Nur Tifa Rachmawati  , Ignatius Soni Kurniawan  , Nala Tri Kusuma
Published: February 2024

The study aims to determine the effect of leader-member exchange (LMX) and work motivation on organizational citizenship behavior (OCB) with mediation of job satisfaction at PT Adi Satria Abadi Yogyakarta. By using a population of PT Adi Satria Abadi employees with a sample size of 80 respondents. The sampling technique used accidental sampling. Data obtained through questionnaires and processed by classical assumption tests and multiple linear regression analysis, as well as the sobel test. So the conclusion is that LMX and work motivation have a significant positive effect on job satisfaction. LMX variables and job satisfaction are not significant on OCB. Work motivation variables have a significant positive effect on OCB. Job satisfaction does not mediate the LMX and work motivation on OCB. The object in this study only covers one branch of PT Adi Satria Abadi Yogyakarta.
Early Exposure of Over-the-Counter Medicine Basic Knowledge among Elementary School Students
Authors: Hanindita Fizkha , Kencana Nyoman Bayu Wisnu , Flavia Domitilla  , Setyajati Flavia Domitila Erika , Setiawati Agustina
Published: February 2024

Recently, self-medication using over-the-counter medicine (OTC) or non-prescription medicine became rapidly popular. Enhancing society's awareness of OTC knowledge and its rational use is greatly significant to promote public health both in adults and children. In the US, a high number of young children are brought to the emergency room due to accidental unsupervised medication each year. Therefore, learning how to self-medicate using OTC at an early age is very critical to improve medication safety in society. This study aims to trained elementary school grades V and IV at the age of 10 to 12 to perceive the basic knowledge of OTC and how to take them safely. This study conducted outreach to students in grades V and VI starting with a pre-test, education dan training, followed by a question-and-answer session, and closed with a post-test. After education and training, the knowledge of the OTC among the students increased, especially significantly in Grade V indicated by post-test score elevating. Thus, this attempt may contribute to increasing the awareness of self-medication using OTC among children.
Optimalisasi Pembukuan dan Pemasaran Berbasis Digital Kelompok Industri Kecil Menengah Pengrajin Perak di Desa Batubulan
Authors: Pramartha I Made Aditya , I Putu Gde Chandra Artha Aryasa  , Anak Agung Istri Krisna Gangga Dewi
Published: February 2024

Pasca pandemi Covid-19, perkembangan industri kerajinan perak yang ada di Desa Batubulan mulai mengalami pertumbuhan. Namun masih terdapat beberapa kendala yang dihadapi oleh para pengrajin perak khususnya  pada bidang operasional dan pemasaran. Berdasarkan hasil wawancara salah satu kelompok pengrajin perak, mekanisme penerimaan pesanan dan pencatatan transaksi masih dilakukan secara konvensional serta proses pemasaran produk terbatas pada pemiliki artshop di Kecamatan Sukawati. Tujuan kegiatan program kemitraan masyarakat ini adalah melakukan transfer pengetahuan terkait proses pembukuan dan pemasaran berbasis digital. Metode yang digunakan adalah pelatihan dan pendampingan. Kegiatan terdiri dari tiga tahapan yakni implemetasi dukungan teknologi dasar, optimalisasi pembukuan berbasis digital, dan optimalisasi pemasaran berbasis digital. Evaluasi kegiatan dilakukan dengan pre-test dan post-test serta monitoring mingguan. Hasil menunjukkan bahwa kegiatan dapat memberikan dampak berupa meningkatnya persepsi pemahaman mitra terhadap peranan teknologi digital, pembukuan berbasis digital, dan pemasaran berbasis digital. Proses transfer pengetahuan kepada mitra dalam kegiatan ini dilakukan dengan efektif melalui rangkaian tahap sistematis yakni sosialisasi, pelatian, dan pendampingan. Kegiatan pendampingan perlu konsisten dilakukan untuk memastikan implementasi teknologi telah berjalan dengan baik.
Community Education on Coffee Pulp Utilization for the Benefits of Green Economy Improvement
Authors: Soetanto Hendrawan , Aprilia Rizka Muizzu , Huda Asri Nurul , Ritonga Azra Salsabila , Hendrawan Viski Fitri
Published: February 2024

The rapid development of Bondowoso regency as coffee production has created serious problems on environmental pollution due to improper and unacceptable coffee pulp (CoP) dumping along the roadside and plantation areas. This study aimed at community education to process CoP into valuable feeed ingredients for ruminant animals and concomitantly reduce the environmental pollution. The methodological approach used a survey, focus group discussion and direct demoplot at the center of coffee farmer’s region at Sukorejo village, Sumberwringin sub-district.  The results showed that almost exclusively the coffee farmers had no prior knowledge on the utilization of CoP as feed ingredients for ruminant animals and the practice of CoP dumping along the roadside and plantation area was associated with the lack of manpower to handle it particularly during the peak harvesting time.The introduction of technology utilizing alkaline ammonia in the form of NaOH to treat CoP during  the demo plot activity revealed that the quality of CoP as represented by the crude protein content and the dry matter digestibility increased by 32.5 % and 63.4 %, respectively indicating that this new product can play a pivotal role as feed ingredients for formulation of ruminant animal’s ration. Additionally, this can be sold at higher price than CoP without treatment which is normally sold at 1,200 IDR/kg and hence it becomes an additional source of income.