bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Cashew Nutshell Extract, Saponins and Tannins Addition on Methane Emissions, Nutrient Digestibility and Feeding Behavior of Beef Steers Receiving a Backgrounding Diet
Authors: Cuervo Wilmer , Gómez Camila , Tarnonsky Federico , Fernandez-Marenchino Ignacio , Maderal Araceli , Podversich Federico , Vargas Juan de J. , DiLorenzo Nicolas
Published: October 2024

The beef industry contributes to greenhouse gas emissions through enteric methane emissions, exacerbating climate change. Anacardic acid in cashew nutshell extract (CNSE), saponins and tannins (ST) are plant secondary metabolites that show promise in methane mitigation via antimicrobial effects, potentially exerting changes in ruminal fermentation patterns. This study examined the impact of CNSE, ST, and their combination on methane emissions, digestibility, intake, and performance of sixteen Angus crossbred steers (347 ± 30 kg) receiving a backgrounding diet (70:30 corn silage: cottonseed burrs). The study used a 4 × 4 Latin square design (4 steers, 4 treatments, 4 periods) with a 2 × 2 factorial arrangement, including the main effects of additive (CNSE or ST) fed individually or combined. Thus, steers received the following treatments: (1) no additive, (2) CNSE only, (3) ST only, or (4) both (CNSEST). Non-supplemented steers registered eight more feedbunk visits/d than ST-steers and spent an extra 10 min/d on the feedbunk. The addition of ST tended to increase dry matter, organic matter, and neutral detergent fiber intake. Additives fed individually reduced CP digestibility. Intake of the carrier containing CNSE only was lesser and coincided with a greater methane yield in that treatment. Digestibility and methane mitigation were improved after CNSEST compared with individual inclusion, suggesting synergistic reactions enhanced methane mitigation effects in fibrous diets without affecting the digestibility of nutrients nor animal growth performance.
Effect of Blood Sampling Time After Colostrum Intake on the Concentration of Metabolites Indicative of the Passive Immunity Transfer in Newborn Dairy Calves
Authors: Mortazavi Mohammad Hassan , Rocha Nathalia Brito , de Paula Marília Ribeiro , Miqueo Evangelina , Salles Marcia Saladini Vieira , Rodrigues Paulo Henrique Mazza , Bittar Carla Maris Machado
Published: October 2024

Due to the synepitheliochorial placental structure, bovines show no maternal antibody flow from mother to fetus during pregnancy, resulting in an agammaglobulemic newborn [...]
Changes in Erythrocytes in 88 Hyperthyroid Cats
Authors: Gójska-Zygner Olga , Kotomski Grzegorz , Gajger Joanna , Norbury Luke J. , Zygner Wojciech
Published: October 2024

Background: There is only a limited number of studies that show alterations in erythrocytes in feline hyperthyroidism. Discrepancies between the findings of these studies may be caused by the presence of concurrent diseases and the use of various haematological analysers. Methods: This study analysed changes in red blood cells (RBCs) in 88 hyperthyroid cats without concurrent diseases, to identify associations between observed changes and to assess the influence of serum thyroxine (T4) concentration, cat age, and sex, on RBC changes. Results: Among the eighty-eight hyperthyroid cats, erythrocytosis was observed in twelve, anaemia in four, macrocytosis in two, and microcytosis in three. Three of the four cases of anaemia probably resulted from concurrent unrecognised disease. Interestingly, all cases of microcytosis were recognized in cats that had erythrocytosis. This study identified a moderate negative correlation between RBC count and mean corpuscular volume (MCV; r = −0.57, p < 0.001). Concluding, it appears that erythrocytosis may be a response to the development of microcytosis. The correlation between RBC count and MCV in hyperthyroid cats may result from the increased action of hepcidin and erythropoietin coupled with the decreased action of thyroid-stimulating hormone (TSH).
Cannabinoids as Antibacterial Agents: A Systematic and Critical Review of In Vitro Efficacy Against Streptococcus and Staphylococcus
Authors: Niyangoda Dhakshila , Aung Myat Lin , Qader Mallique , Tesfaye Wubshet , Bushell Mary , Chiong Fabian , Tsai Danny , Ahmad Danish , Samarawickrema Indira , Sinnollareddy Mahipal , Thomas Jackson
Published: October 2024

Background: Two major bacterial pathogens, Staphylococcus aureus and Streptococcus pyogenes, are becoming increasingly antibiotic-resistant. Despite the urgency, only a few new antibiotics have been approved to address these infections. Although cannabinoids have been noted for their antibacterial properties, a comprehensive review of their effects on these bacteria has been lacking. Objective: This systematic review examines the antibacterial activity of cannabinoids against S. aureus, including methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) strains, and S. pyogenes. Methods: Databases, including CINAHL, Cochrane, Medline, Scopus, Web of Science, and LILACS, were searched. Of 3510 records, 24 studies met the inclusion criteria, reporting on the minimum inhibitory concentration (MIC) and minimum bactericidal concentration of cannabinoids. Results: Cannabidiol (CBD) emerged as the most effective cannabinoid, with MICs ranging from 0.65 to 32 mg/L against S. aureus, 0.5 to 4 mg/L for MRSA, and 1 to 2 mg/L for VRSA. Other cannabinoids, such as cannabichromene, cannabigerol (CBG), and delta-9-tetrahydrocannabinol (Δ9-THC), also exhibited significant antistaphylococcal activity. CBD, CBG, and Δ9-THC also showed efficacy against S. pyogenes, with MICs between 0.6 and 50 mg/L. Synergistic effects were observed when CBD and essential oils from Cannabis sativa when combined with other antibacterial agents. Conclusion: Cannabinoids’ antibacterial potency is closely linked to their structure–activity relationships, with features like the monoterpene region, aromatic alkyl side chain, and aromatic carboxylic groups enhancing efficacy, particularly in CBD and its cyclic forms. These results highlight the potential of cannabinoids in developing therapies for resistant strains, though further research is needed to confirm their clinical effectiveness.
Anti-Staphylococcus aureus Activity of Volatile Phytochemicals and Their Combinations with Conventional Antibiotics Against Methicillin-Susceptible S. aureus (MSSA) and Methicillin-Resistant S. aureus (MRSA) Strains
Authors: Nikolic Isidora , Aleksic Sabo Verica , Gavric Damir , Knezevic Petar
Published: October 2024

Background: MSSA and MRSA strains are challenging human pathogens that can develop resistance to antibiotics, highlighting the need for alternative antimicrobial agents. Plant metabolites, particularly volatile phytochemicals, may offer promising antimicrobial properties. The aim was to evaluate the antimicrobial and antibiofilm efficacy of various commercial volatile phytochemicals from the terpene and terpenoid groups against reference MSSA and MRSA strains, focusing on synergistic effects in both binary combinations and combinations with antibiotics. Methods: The microdilution method was used to determine the minimum inhibitory concentrations (MICs) for antibiotics and phytochemicals. The checkerboard method assessed synergistic interactions between phytochemicals and between phytochemicals and antibiotics, while the time-kill method was used to confirm these results. Biofilm quantification was performed using the microtiter plate method to evaluate the effects of phytochemicals, antibiotics, and their binary combinations on the eradication of 48-h-old biofilms. Results: Carvacrol and thymol demonstrated the strongest anti-staphylococcal activity, while other terpene compounds showed weaker effects. In binary combinations, carvacrol and thymol exhibited synergy against one MSSA strain (FICI = 0.50) and with tetracycline and chloramphenicol (FICI = 0.28–0.50). Synergy was also noted with streptomycin sulfate against one MRSA strain (FICI = 0.31–0.50) and with other antibiotics, including gentamicin (FICI = 0.25–0.50) and oxacillin (FICI = 0.44). Additionally, effective combinations achieved over 50% biofilm removal at both minimum inhibitory and sub-inhibitory concentrations. Conclusions: Results showed that synergy varies based on strain sensitivity to chemical agents, highlighting their potential for personalized therapy. Despite the difficulty in removing preformed biofilms, the findings highlight the importance of combined treatments to enhance antibiotic effectiveness.
Prescription Practices and Usage of Antimicrobials in a Tertiary Teaching Hospital in Rwanda: A Call for Antimicrobial Stewardship
Authors: Igizeneza Acsa , Bitunguhari Leopold , Masaisa Florence , Hahirwa Innocent , Uwamahoro Lorette D. , Sebatunzi Osee , Umugwaneza Nathalie , Pauwels Ines , Versporten Ann , Vlieghe Erika , Ahmed Ayman , Ngabonziza Jean Claude S. , Theunissen Caroline
Published: October 2024

Background: Antimicrobial resistance (AMR) is a global problem that results in high morbidity and mortality, particularly in low- and middle-income countries. Inappropriate use of antimicrobials is a major driver of AMR. This study aimed to evaluate the rate and quality of antimicrobial prescription and use at the University Teaching Hospital of Kigali (CHUK), a tertiary-referral teaching hospital. Methodology: A point prevalence survey (PPS) of antimicrobial prescription was conducted using the Global PPS tool, including a healthcare-acquired infection (HAI) module. Results: On the day of the PPS, 39.3% (145/369) of inpatients were prescribed at least one antimicrobial. Out of the 259 prescribed antimicrobials, 232 (89.6%) were antibacterials, of which 151 (65.1%) belonged to the watch group of the WHO AWaRe classification. The top three antibiotics prescribed were cefotaxime (87; 37.5%), parenteral metronidazole (31; 13.4%), and meropenem (23; 9.9%). Stop or review dates for the prescribed antimicrobials were documented in 27/259 prescriptions (10.4%). Surgical prophylaxis (SP) was prescribed for longer than one day in 83.3% of 61 patients. Samples for culture were sent for 27.1% (63/232) of all the patients prescribed antibiotics. Conclusion: This PPS demonstrates multiple indicators of the poor use of antimicrobials, including the high prevalence usage of watch antibiotics and prolonged surgical prophylaxis and other poor-quality indicators. Thus, there is an urgent need for intervention to improve antimicrobial stewardship.
miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma
Authors: Escobar Moreno José Daniel , Fajardo Castiblanco José Luis , Riaño Rodriguez Laura Camila , Barrios Ospina Paula Marcela , Zabala Bello Carlos Andrés , Muñoz Roa Esther Natalia , Rivera Escobar Hernán Mauricio
Published: October 2024

Reactive oxygen species (ROS) are intermediates in oxidation–reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidative factors and the antioxidant response of the organism, a phenomenon known as oxidative stress. Evidence suggests that the differential modulation of ROS-mediated oxidative stress occurs in the pathogenesis and progression of melanoma, and that this imbalance in redox homeostasis appears to be functionally linked to microRNA (miRNA o miRs)-mediated non-mutational epigenetic reprogramming involving genes and transcription factors. The relationship between ROS-mediated stress control, tumour microenvironment, and miRNA expression in melanoma is not fully understood. The aim of this review is to analyse the involvement of miRNAs in the modulation of the signalling pathways involved in ROS-mediated oxidative stress in melanoma. It is hoped that these considerations will contribute to the understanding of the mechanisms associated with a potential epigenetic network regulation, where the modulation of oxidative stress is consolidated as a common factor in melanoma, and therefore, a potential footprint poorly documented.
Chemical Constituents from the Fruit of Melia azedarach and Their Anti-Inflammatory Activity
Authors: Cao Fan , Chen Jing , Lin Zheng-Tao , Lin Han-Ying , Liu Bin , Chen Zhen-Wei , Ma Xin-Hua , Zhang Yong-Hong
Published: October 2024

Phytochemical investigations of Melia azedarach fruits have led to the isolation of a novel tirucallane triterpenoid (1), four new limonoids (2–5), and four known limonoids (6–9). Their structures were clarified by comprehensive spectroscopic and spectrometric analyses. The anti-inflammatory activities of isolated compounds were assessed in vitro. Compound 2 exhibited the most potent anti-inflammatory effect, with an IC50 value of 22.04 μM. Additionally, compound 2 attenuated LPS-induced reactive oxygen species (ROS) production and reduced the levels of inflammatory mediators IL-6 and TNF-α. A mechanistic study revealed that limonoid 2 suppresses the expression of iNOS and JAK2 and is implicated in the modulation of the NF-κB signaling cascade, which reveals its anti-inflammatory actions.
Research on the Influence of Rectifying Orifice Plate on the Airflow Uniformity of Exhaust Hood
Authors: Liu Lindong , Du Cuifeng , Wang Yuan , Yang Bin
Published: October 2024

Designing and improving collection systems for dust and toxic pollutants is crucial for improving the safety and indoor air quality of laboratory buildings. Push–pull ventilation systems with uniformly distributed parallel airflow have been proven to be of great help in this task. Designing exhaust hoods with parallel airflow distribution can effectively enhance the airflow uniformity of push–pull ventilation systems, especially when combining it with the implementation of rectifying orifice plates on the exhaust hoods. Therefore, this study combines a computational fluid dynamics (CFD) method and experimental approach to analyze the influence of key factors that lead to improvements in the airflow uniformity through the use of rectifying orifice plates, namely the aperture and porosity, as well as the number of rectifying orifice plates on the airflow uniformity of exhaust hoods. The study shows the following: (1) The aperture of the rectifying orifice plate considerably affects the airflow uniformity of the exhaust hood. Specifically, near the exhaust hood outlet, the airflow uniformity is negatively correlated with the aperture; conversely, near the exhaust hood inlet, the airflow uniformity is positively correlated with the aperture. (2) A rectifying orifice plate with a porosity of 35.43% can effectively improve the airflow uniformity of the exhaust hood. (3) Exhaust hoods with a double-layer rectifying orifice plate structure can improve airflow uniformity by approximately 40% compared to those with a single-layer structure. The above research results can guide the optimization of exhaust hood design to improve airflow uniformity, thereby effectively enhancing the capture efficiency of the push–pull ventilation system for dust and toxic pollutants and providing a safer environment for experimenters in laboratory buildings.
Printing the Future Layer by Layer: A Comprehensive Exploration of Additive Manufacturing in the Era of Industry 4.0
Authors: Bănică Cristina-Florena , Sover Alexandru , Anghel Daniel-Constantin
Published: October 2024

In the era of Industry 4.0, 3D printing, or additive manufacturing (AM), has revolutionized product design and manufacturing across various sectors. This review explores the evolution of 3D printing technology and its impact on industrial innovation, highlighting advancements in aeronautics, the automotive industry, and biomedicine. Various AM processes, such as binder jetting, direct energy deposition, and powder bed fusion, and materials like metals, polymers, ceramics, and composites, are discussed. Innovations like high-speed sintering, continuous liquid interface production, and bioprinting demonstrate ongoing advancements. The potential of 3D printing in personalized medical applications is emphasized due to its flexibility in geometry and materials. Despite progress, challenges like standardization, material quality, recycling, sustainability, and economic feasibility hinder widespread adoption. Overcoming these challenges is crucial for optimizing 3D printing technologies, ensuring high-quality, efficient, and affordable production. The review also addresses the future prospects of 4D and 5D printing technologies and their potential applications in various industries. This overview underscores 3D printing’s role in shaping the future of manufacturing within the context of Industry 5.0, emphasizing human–machine collaboration and sustainability.
A Novel Spring-Actuated Low-Velocity Impact Testing Setup
Authors: Kucuk Mesut , Hejazi Moheldeen , Sari Ali
Published: October 2024

Evaluating the behavior of materials and their response under low-velocity dynamic impact (less than 30 m/s) is a challenging task in various industries. It requires customized test methods to replicate real-world impact scenarios and capture important material responses accurately. This study introduces a novel spring-actuated testing setup for low-velocity impact (LVI) scenarios, addressing the limitations of existing methods. The setup provides tunable parameters, including adjustable impactor mass (1 to 250 kg), velocity (0.1 to 32 m/s), and spring stiffness (100 N/m to 100 kN/m), allowing for flexible simulation of dynamic impact conditions. Validation experiments on steel plates with a support span of 800 mm and thickness of 5 mm demonstrated the system’s satisfactory accuracy in measuring impact forces (up to 714.2 N), displacements (up to 40.5 mm), and velocities. A calibration procedure is also explored to estimate energy loss using numerical modeling, further enhancing the test setup’s precision and utility. The results underline the effectiveness of the proposed experimental setup in capturing material responses during low-velocity impact events.
Long-Term Teleconnections Between Global Circulation Patterns and Interannual Variability of Surface Air Temperature over Kingdom of Saudi Arabia
Authors: Almaashi Abdullkarim K. , Hasanean Hosny M. , Labban Abdulhaleem H.
Published: October 2024

Surface air temperature (SAT) variability is investigated for advancing our understanding of the climate patterns over the Kingdom of Saudi Arabia (KSA). SAT variability reveals significant warming trends, particularly from 1994 onward, as demonstrated by nonlinear and linear trend analysis. This warming is linked to global climate patterns, which serve as significant indicators for studying the effects of climate change on surface air temperature patterns across the KSA. The empirical orthogonal function (EOF) method is employed for analyzing SAT due to its effectiveness in extracting dominant patterns of variability during the winter (DJF) and summer (JJA) seasons. The first mode (EOF1) for both seasons shows positive variability across the KSA, explaining more than 45% of the variance. The second mode (EOF2) indicates negative variability in central and northern regions. The third mode (EOF3) describes positive variability but with lower variance over time. PC1 is used to describe the physical mechanism of SAT variability and correlations with global sea surface temperature (SST). The physical mechanism shows that the variability in Mediterranean troughs during the winter season and high pressure over the Indian Ocean and central Asia controls SAT variability over the KSA. The correlation coefficients (CCs) were calculated during the winter and summer season between the SAT of the KSA and six teleconnection indices, El Niño Southern Oscillation (ENSO), Indian Ocean Dipole (IOD), Atlantic Meridional Mode (AMM), Pacific Warm Pool (PWP), North Atlantic Oscillation (NAO), and Tropical North Atlantic (TNA) SST for the period from 1994 to 2022. ENSO shifts from positive to negative correlations with SAT from winter to summer. IOD shows a diminished correlation with SAT due to the absence of upper air dynamics. PWP consistently enhances surface warming in both seasons through upper air convergence during both seasons. AMM and NAO have a non-significant impact on SAT; however, TNA contributes warming over central and northern parts during winter and summer seasons. The seasonal SAT variations emphasize the significant role of ENSO, PWP, and TNA across the seasons. The findings of this study can be helpful for seasonal predictability in the KSA.
Assessment of Mortality Attributable to Air Pollution in the Urban Area of Pisa (Central Italy) Characterized by Multi-Source Exposures
Authors: Bustaffa Elisa , Redini Marco , Minichilli Fabrizio
Published: October 2024

Air pollution is one of the main risk factors for human health. The aim of this study was to provide an Integrated Environmental and Health Impact Assessment (IEHIA) tool to estimate the impacts on both environment and human health in Pisa municipality (central Italy). For each pollutant considered (PM2.5, PM10, and NO2), both Population-Weighted Exposure (PWE) and Attributable Deaths (ADs) were calculated considering the difference between the PWE and the latest air quality guidelines suggested by the World Health Organization. The PWEs were 16.1 µg/m3, 24.9 µg/m3, and 25.9 µg/m3 for PM2.5, PM10, and NO2, respectively. The ADs from natural causes due to exposure to PM2.5, PM10, and NO2 were 63, 29, and 51, respectively. The AD distribution was mainly concentrated in urban areas for particulate matter and in urban and suburban areas for NO2. The results highlighted significantly higher levels of air pollution than the reference levels, with a percentage of ADs from natural causes of approximately 6% of the total mortality in Pisa. IEHIA offers support for environmental and health policies and territorial planning. The authors recommend the adoption of prevention measures aimed at mitigating air pollution in critical areas, with a consequent reduction in avoidable mortality.
Addressing Low-Cost Methane Sensor Calibration Shortcomings with Machine Learning
Authors: Kiplimo Elijah , Riddick Stuart N. , Mbua Mercy , Upreti Aashish , Anand Abhinav , Zimmerle Daniel J.
Published: October 2024

Quantifying methane emissions is essential for meeting near-term climate goals and is typically carried out using methane concentrations measured downwind of the source. One major source of methane that is important to observe and promptly remediate is fugitive emissions from oil and gas production sites but installing methane sensors at the thousands of sites within a production basin is expensive. In recent years, relatively inexpensive metal oxide sensors have been used to measure methane concentrations at production sites. Current methods used to calibrate metal oxide sensors have been shown to have significant shortcomings, resulting in limited confidence in methane concentrations generated by these sensors. To address this, we investigate using machine learning (ML) to generate a model that converts metal oxide sensor output to methane mixing ratios. To generate test data, two metal oxide sensors, TGS2600 and TGS2611, were collocated with a trace methane analyzer downwind of controlled methane releases. Over the duration of the measurements, the trace gas analyzer’s average methane mixing ratio was 2.40 ppm with a maximum of 147.6 ppm. The average calculated methane mixing ratios for the TGS2600 and TGS2611 using the ML algorithm were 2.42 ppm and 2.40 ppm, with maximum values of 117.5 ppm and 106.3 ppm, respectively. A comparison of histograms generated using the analyzer and metal oxide sensors mixing ratios shows overlap coefficients of 0.95 and 0.94 for the TGS2600 and TGS2611, respectively. Overall, our results showed there was a good agreement between the ML-derived metal oxide sensors’ mixing ratios and those generated using the more accurate trace gas analyzer. This suggests that the response of lower-cost sensors calibrated using ML could be used to generate mixing ratios with precision and accuracy comparable to higher priced trace methane analyzers. This would improve confidence in low-cost sensors’ response, reduce the cost of sensor deployment, and allow for timely and accurate tracking of methane emissions.
Coefficient-Shuffled Variable Block Compressed Sensing for Medical Image Compression in Telemedicine Systems
Authors: Monika R , Dhanalakshmi Samiappan , Rajamanickam Narayanamoorthi , Yousef Amr , Alroobaea Roobaea
Published: October 2024

Medical professionals primarily utilize medical images to detect anomalies within the interior structures and essential organs concealed by the skeletal and dermal layers. The primary purpose of medical imaging is to extract image features for the diagnosis of medical conditions. The processing of these images is indispensable for evaluating a patient’s health. However, when monitoring patients over extended periods using specific medical imaging technologies, a substantial volume of data accumulates daily. Consequently, there arises a necessity to compress these data in order to remove duplicates and speed up the process of acquiring data, making it appropriate for effective analysis and transmission. Compressed Sensing (CS) has recently gained widespread acceptance for rapidly compressing images with a reduced number of samples. Ensuring high-quality image reconstruction using conventional CS and block-based CS (BCS) poses a significant challenge since they rely on randomly selected samples. This challenge can be surmounted by adopting a variable BCS approach that selectively samples from diverse regions within an image. In this context, this paper introduces a novel CS method that uses an energy matrix, namely coefficient shuffling variable BCS (CSEM-VBCS), tailored for compressing a variety of medical images with balanced sparsity, thereby achieving a substantial compression ratio and good reconstruction quality. The results of experimental evaluations underscore a remarkable enhancement in the performance metrics of the proposed method when compared to contemporary state-of-the-art techniques. Unlike other approaches, CSEM-VBCS uses coefficient shuffling to prioritize regions of interest, allowing for more effective compression without compromising image quality. This strategy is especially useful in telemedicine, where bandwidth constraints often limit the transmission of high-resolution medical images. By ensuring faster data acquisition and reduced redundancy, CSEM-VBCS significantly enhances the efficiency of remote patient monitoring and diagnosis.
A Gait Analysis in Professional Dancers: A Cross-Sectional Study
Authors: Obi Manghe Fidelis , Gina Walther , Goswami Tarun
Published: October 2024

A gait analysis serves as a critical tool for examining the biomechanical differences in movement patterns between trained and untrained individuals. This study investigates the nuanced differences in gait patterns between professional ballet dancers and non-dancers, with a focus on angular velocities and accelerations across key body joints. By analyzing the positions and movements of the head, neck, shoulder, spine, hip, knee, and ankle in both the sagittal (SP) and frontal (FP) planes, the study aims to identify key distinctions in joint dynamics that arise from differing levels of physical training. The study involved ten participants in total, comprising four professional female ballet dancers and six non-dancer students (three males and three females). In the first experiment, participants performed walking trials at five different speeds, while in the second experiment, the ballet dancers performed six distinct dance routines. Data were captured using a Kinetics motion capture camera system, which recorded the maximum and minimum angular velocities and accelerations during both walking and dancing. Key findings reveal significant differences in joint dynamics. For example, non-dancers’ right shoulder exhibited a maximum angular velocity of −0.47 rad/s and a minimum of 0.71 rad/s, while dancers showed a maximum of −0.09 rad/s and a minimum of 0.07 rad/s. The right knee also displayed notable differences, with angular velocities ranging from −3.88 rad/s to 2.61 rad/s for non-dancers, compared to −0.35 rad/s to 0.54 rad/s for dancers. In terms of acceleration, dancers’ left shoulder reached a maximum of 3.952 mm/s2, while their right shoulder had a minimum of −0.1 mm/s2. For non-dancers, the left elbow showed a maximum acceleration of 2.997 mm/s2, while the right elbow had a minimum of 0.05 mm/s2. These variations in angular velocity and acceleration underscore the distinct roles and movements of various joints, highlighting differences in muscle coordination and joint control. Understanding these patterns is crucial for assessing joint function, optimizing training, and developing intervention strategies for injury prevention and rehabilitation. The findings hold significant implications for the dance community and other physically active populations, offering valuable insights into performance enhancement and movement health.
Telomere Length and Biological Aging: The Role of Strength Training in 4814 US Men and Women
Authors: Tucker Larry A. , Bates Carson J.
Published: October 2024

Telomere length is an index of cellular aging. Healthy lifestyles are associated with reduced oxidative stress and longer telomeres, whereas unhealthy behaviors are related to shorter telomeres and greater biological aging. This investigation was designed to determine if strength training accounted for differences in telomere length in a random sample of 4814 US adults. Data from the National Health and Nutrition Examination Survey (NHANES) were employed to answer the research questions using a cross-sectional design. Time spent strength training was calculated by multiplying days of strength training per week by minutes per session. Participation in other forms of physical activity was also calculated based on reported involvement in 47 other activities. Weighted multiple regression and partial correlation were used to calculate the mean differences in telomere length across levels of strength training, adjusting for differences in potential confounders. With the demographic covariates controlled, strength training and telomere length were linearly related (F = 14.7, p = 0.0006). Likewise, after adjusting for all the covariates, the linear association remained strong and significant (F = 14.7, p = 0.0006). In this national sample, 90 min per week of strength training was associated with 3.9 years less biological aging, on average. Regular strength training was strongly related to longer telomeres and less biological aging in 4814 US adults.
Neuroprotective Effects of Ascorbic Acid, Vanillic Acid, and Ferulic Acid in Dopaminergic Neurons of Zebrafish
Authors: Hedayatikatouli Fatemeh , Kalyn Michael , Elsaid Dana , Mbesha Herman Aishi , Ekker Marc
Published: October 2024

Background/Objectives: Parkinson’s disease (PD) is a debilitating neurodegenerative disease that targets the nigrostriatal dopaminergic (DAnergic) system residing in the human midbrain and is currently incurable. The aim of this study is to investigate the neuroprotective effects of ascorbic acid, vanillic acid, and ferulic acid in a zebrafish model of PD induced by MPTP by assessing the impact of these compounds on DAnergic neurons, focusing on gene expression, mitochondrial dynamics, and cellular stress responses. Methods/Results: Following exposure and qPCR and immunohistochemical analyses, ascorbic acid enhanced DAnergic function, indicated by an upregulation of the dopamine transporter (dat) gene and increased eGFP+ DAnergic cells, suggesting improved dopamine reuptake and neuroprotection. Ascorbic acid also positively affected mitochondrial dynamics and stress response pathways, countering MPTP-induced dysregulation. Vanillic acid only had modest, if any, neuroprotective effects on DAnergic neurons following MPTP administration. Ferulic acid exhibited the largest neuroprotective effects through the modulation of gene expression related to DAnergic neurons and mitochondrial dynamics. Conclusions: These findings suggest that ascorbic acid and ferulic acid can act as potential protective interventions for DAnergic neuron health, demonstrating various beneficial effects at the molecular and cellular levels. However, further investigation is needed to translate these results into clinical applications. This study enhances the understanding of neuroprotective strategies in neurodegenerative diseases, emphasizing the importance of considering interactions between physiological systems.
Amplifying Cognitive Functions in Amateur Esports Athletes: The Impact of Short-Term Virtual Reality Training on Reaction Time, Motor Time, and Eye–Hand Coordination
Authors: Lachowicz Maciej , Serweta-Pawlik Anna , Konopka-Lachowicz Alicja , Jamro Dariusz , Żurek Grzegorz
Published: October 2024

Objectives: Electronic sports (esports) have grown into a major competitive field in today’s digital landscape, attracting the interest of established companies and evolving into a fast-growing industry. Cognitive function, including reaction time, motor time, and eye–hand coordination, plays a crucial role in e-athlete performance. This study aims to examine the impact of VR training on these cognitive functions in amateur e-athletes. Methods: The study involved 66 amateur e-athletes (45 men and 21 women, aged 19–41, with a mean age of 23.96 ± 3.90 years) who reported active, non-professional involvement in esports. Participants were randomly assigned to an experimental group (E) (n = 32) and a control group (C) (n = 34), with initial comparisons confirming no significant differences in daily gaming habits, esports experience, or age between groups. The E group completed 15-minute daily training sessions using the VR game Beat Saber over eight consecutive days. Results: The results demonstrated that VR training significantly improved eye–hand coordination in the experimental group, although there were no notable effects on reaction time or motor time. Conclusions: These findings suggest that VR training may be an effective method to enhance certain cognitive functions, specifically eye–hand coordination, among amateur e-athletes. This could offer a valuable approach for performance improvement in this rapidly growing field.
Trauma-Based Sexually Dimorphic Changes in the Connectome and Its Association with Central Sensitization Syndromes—A Systematic Review
Authors: Quodling Nicole , Groves Shad , Hoffman Norman , Carrick Frederick R. , Jemni Monèm
Published: October 2024

Background/Objectives: Chronic pain syndromes pose a significant global health challenge to patients and physicians with a complex relationship of biological and psychosocial factors that are only partly understood. Emerging research suggests an association between prenatal and childhood adversity and the development of somatic syndromes, particularly in females. This study aims to explore the relationship between sexual dimorphic epigenetic changes in the connectome and prenatal and early life adversity (ELA). Methods: A review of the existing literature was conducted, examining studies utilizing MRI to identify critical periods of environmental influence on neural phenotypes. Results: The findings indicate a significant association between prenatal and childhood adversity and the emergence of central sensitization syndromes, particularly among females. Notably, alterations in grey matter volume and neural connectivity patterns were observed, suggesting that early adverse experiences can influence pain signaling mechanisms. Conclusions: Understanding the role of sex differences in brain circuitry is crucial for developing personalized pain management strategies. This study highlights the importance of considering both biological and psychosocial factors in addressing chronic pain, as interventions based predominantly on male subjects may be less effective for females. Further research is warranted to explore these differences and refine therapeutic approaches.
Stress-Induced Ultrasonic Vocalization in Laboratory Rats and Mice: A Scoping Review
Authors: Venkatraman Anumitha , Bretl Michelle , Kim Se-in , Christensen Leslie , Kelm-Nelson Cynthia A. , Ciucci Michelle R. , Thibeault Susan L.
Published: October 2024

Introduction: Ultrasonic vocalization (USV) can indicate affective states—including psychosocial stress—in mice and rats. However, stress-induced USV changes could be confounded by laboratory experimental variables such as the type of behavioral stress paradigm, the elicitation method, rodent strain, etc. We sought to provide a review of the current literature to delineate how psychosocial stress-altered rodent USVs may be affected by factors of age, sex, strain, species, elicitation paradigm, and stressor. Methods: We used PubMed, Scopus (Elsevier), PsycINFO (EBSCO), and the following Web of Science (Clarivate) databases: Biological Abstracts, CAB Abstracts, Science Citation Index-Expanded, and Emerging Sources Citation Index. The studies identified by our search strategy were independently screened by two authors with the following inclusion criteria: peer-reviewed, in English, reported original data, and described USV in response to stress in rats or mice. The data extracted included USV acoustic parameters (mean peak frequency and mean amplitude (loudness)), details of the stress and USV elicitation paradigms, rodent species, age, and sex variables. Results: The following screening of 5309 titles/abstracts and 687 full-text articles revealed 148 articles. Footshock (20%), cold exposure (14%), and maternal separation (23.5%) were the most commonly used stress paradigms (duration and type of stressor varied across studies), with the total number of USV calls being the most commonly reported acoustic outcome. In rats, 121 articles described stress-altered USVs, while 25 studies reported the same in mice, and two reported multiple rodent species (rats and mice, alongside other rodent species such as gerbils). With respect to stress-altered USV changes with age, mice and rats increase USV rates after birth, with a peak around 6 to 10 days, and decrease USVs until weanling age. Of the five studies that reported sex-related differences in stress-induced USVs, females had an increased number of calls and lower average peak frequency in response to stress when compared to males. Only two to four studies reported strain-related differences in stress-induced vocalizations in rats and mice, respectively. Conclusions: The data from this review lay the groundwork for better understanding rodent USVs in response to psychosocial stress with effects of elicitation paradigm, stressor, age, and sex.
Structural Design and Technology of Pocket Foundations for Long Precast Concrete Columns in Seismic Areas
Authors: Constantinescu Horia , Toader Traian-Nicu
Published: October 2024

The connection between a prefabricated reinforced concrete column and a pocket foundation is a case treated from a general perspective in the European Standard named EN 1992-1-1 (EC2), and when the structural engineer deals with the dimensioning or verification of the connection, he must tackle several unknowns. The present work aims to fill in the missing information by presenting detailed calculation models based on the strut-and-tie method for four widely used pocket foundations: a pedestal pocket foundation with smooth, rough or keyed internal walls and a pad foundation with a pocket possessing keyed internal walls. In establishing the strut-and-tie models and writing the equation for the internal forces, we consider several standards (EC2, NBR 9062 and DIN 1045-1), good practices (from Austria, England, Germany and Romania) and numerous experimental and numerical investigations. Additionally, detailed design prescriptions applicable to seismic areas are given. This manuscript covers a wide range of design and technology aspects necessary for designing and building columns connected with pocket foundations, information for which is shown only in fragmented form or partially in other publications. Afterward, as a case study, a pocket foundation is designed in all four variations, with the structural design particularities, similitudes and differences being pointed out. Finally, to conclude, we mention the advantages and disadvantages of pocket foundations with respect to the type of internal wall surface used. Quantifiable data based on the case study undertaken are available.
Study of Flow Characteristics and Anti-Scour Protection Around Tandem Piers Under Ice Cover
Authors: Gao Pengcheng , Chang Lei , Mou Xianyou , Gao Feng , Su Haitao , Zhang Bo , Shang Zhiqiang , Gao Lina , Qin Haode , Ma Hui
Published: October 2024

The impact of an ice-covered environment on the local flow characteristics of a bridge pier was studied through a series of flume tests, and the dominant factors affecting the scour pattern were found to grasp the change laws of the local hydrodynamic characteristics of the bridge pier under the ice cover. At the same time, because the scour problem of the pier foundation is a technical problem throughout the life-cycle of the bridge, to determine the optimal anti-scour protection effect on the foundation of the bridge pier, active protection scour plate was used to carry out scour protection tests, and its structural shape was optimized to obtain better anti-scour performance. The test results show that the jumping movements of sediment particles in the scour hole around the pier are mainly caused by events Q2 and Q4, which are accompanied by events Q1 and Q3 and cause the particle rolling phenomenon, where Q1 and Q3 events are outward and inward interacting flow regimes, and Q2 and Q4 events are jet and sweeping flow regimes, respectively. The power spectral attenuation rate in front of the upstream pier is high without masking effects, while strong circulation at the remaining locations results in strong vorticity and high spectral density, in particular, when the sampling time series is 60 s (i.e., f = 1/60), the variance loss rates under ice-covered conditions at the front of the upstream pier, between the two piers, and at the tail end of the downstream pier are 0.5%, 4.6%, and 9.8%, respectively, suggesting a smaller contribution of ice cover to the variance loss.
Influence of the Internal Friction Resistance on the Vertical Compressive Bearing Capacity of Large-Diameter Steel Pipe Piles
Authors: Shu Jiaqing , Gu Xiaoqing , Wang Tengfei , Li Xiaojuan , Zhu Mingxing
Published: October 2024

Current calculation methods for the vertical bearing capacity of steel pipe piles are predominantly designed for smaller diameters and do not account for the soil inside the pile. This necessitates an evaluation of their applicability to piles with diameters exceeding 2.0 m. This study aims to refine the existing formula for calculating vertical bearing capacity, as outlined in the Port Engineering Foundation Code of China, by investigating the vertical bearing capacity of large-diameter steel pipe piles through numerical simulations. By analyzing the relationship between the internal friction resistance of the soil core within the pipe and the bearing capacity for diameters ranging from 2 m to 10 m, this paper proposes a revised formula specifically tailored for steel pipe piles with diameters greater than 2 m, incorporating the effect of the soil core. The validity of the proposed formula is then confirmed through comparison with field data from four large-diameter steel pipe piles. The results demonstrate that the modified method proposed in this study performs better than the original formula when compared with the measured data.
Advances in Cold-Climate-Responsive Building Envelope Design: A Comprehensive Review
Authors: Al-Shatnawi Zahra , Hachem-Vermette Caroline , Lacasse Michael , Ziaeemehr Bahador
Published: October 2024

Extreme low temperatures, heavy snowfall, ice accumulation, limited daylight, and increased energy consumption in cold climates present significant challenges but also offer opportunities for improving building efficiency. Advanced materials and technologies in climate-responsive envelopes can enhance sustainability, reduce carbon footprints and operational costs, and improve thermal comfort under these environmental conditions. This literature review combines theoretical aspects of building performance in cold climates with a summary of current and critical applications in building envelope design, identifying research gaps and proposing future research directions. It has been shown that various BIPV systems require further climate-based studies to optimize solar energy yield. For example, integrating PV layers and PCM within DSFs can reduce cooling loads, but more research is needed on PCM transition temperatures and ventilation strategies in cold climates. A notable research gap exists in building-integrated vegetative systems, particularly regarding soil thickness, irrigation, hygrothermal performance, and snow accumulation. Despite excellent winter performance in buildings incorporating CLT components, they face increased cooling energy consumption and potential overheating in summer. Additionally, the high initial moisture content in CLT raises the risk of mold growth, especially when covered with vapor-tight layers. The design examples in this paper emphasize the need for further investigation to achieve sustainable, low-carbon, energy-efficient envelope designs for cold climates.
Seismic Vulnerability Assessment of the Cliff-Attached Buildings Equipped with Energy Dissipation Devices Under Obliquely Incident Seismic Waves
Authors: Yang Zhuoxin , Liu Dewen , Zhou Jiayu , Zhang Li , Liao Wenyuan
Published: October 2024

Cliff-attached structures are structures attached to slopes and connected tightly, which is particularly complex to analyze due to the foundations’ unequal grounding and the lateral stiffness’ irregularity. In rare earthquakes, seismic waves are usually obliquely incident on the foundation at a certain angle. Therefore, it is not appropriate to consider only seismic waves’ vertical incidence, and it is necessary to consider multi-angle oblique incidence. In this paper, based on the theory of viscous-spring artificial boundary and the principle of equivalent nodes at the interface of oblique incidence of ground shaking P-waves, and combined with the dynamic properties related to Buckling-Restrained Brace, the numerical models of slopes and two kinds of cliff-attached structures considering the slope amplification effect and soil-structure interaction are established. The dynamic response of the obliquely incident seismic waves under the action of the cliff-attached vibration reduction structure is studied in depth, and the additional effective damping ratios of the nonlinear energy-dissipated units based on the deformation energy are compared and analyzed. It is shown that under the four oblique incidence angles of incidence (compression waves in the vertical plane) studied in this paper, the seismic dynamic response and damage degree peaked at an angle of incidence of 60°, with a tendency to increase and then decrease with increasing angles of incidence. The ability of an energy-dissipating vibration reduction device to change structural vibration characteristics decreases with an increase in incidence angle. The difference between the total strain energy of the structure in the X-direction (Transverse slope direction) and Y-direction (Down-slope direction) and the total energy dissipation of the dissipative components is obvious, with the X-direction being about 10 times that of the Y-direction.