bluuebunny/crossref_metadata_2025 huggingface dataset:
Biodegradation of Residues from the Palo Santo (Bursera graveolens) Essential Oil Extraction and Their Potential for Enzyme Production Using Native Xylaria Fungi from Southern Ecuador
Authors: Carrión-Paladines Vinicio , Fries Andreas , Caballero Rosa Elena , Pérez Daniëls Pablo , García-Ruiz Roberto
Published: August 2019

The degradation dynamics of lignin and cellulose were analyzed by means of a solid state biodegradation experiment, using residues from the essential oil extraction of the Palo Santo tree (Bursera graveolens). As such, two native Xylaria spp. and an exotic mushroom Trametes versicolor were incubated on the spent substrate (Residues of B. Graveolens, BGR’s). The relatively high lignin and cellulose contents of the BGRs (9.1% and 19%, respectively) indicated the potential of this resource for the production of methane (biogas) and ethanol. However, the degradation of the lignin and cellulose content could be traced back to the relatively high activity of the enzymes laccase, cellulase, and xylanase, produced by the fungi. The results showed that laccase (30.0 U/L and 26.6 U/L), cellulase (27.3 U/L and 35.8 U/L) and xylanase (189.7U/L and 128.3 U/L) activities of Xylaria feejeensis and Xylaria cf. microceras were generally higher than T. versicolor (9.0 U/L, 29.5 U/L, 99.5 U/L respectively). Furthermore, the total carbon (TC: 47.3%), total nitrogen (TN: 1.5%), total phosphorus (TP: 0.2%) and total potassium (TK: 1.2%) dynamics were analyzed during the experiment and their importance for the degradation process highlighted. The results of this work might serve as guidance for future studies in dry forest areas, while furthering the understanding of the potential use of native fungi as ecologic lignocellulosic decomposers and for industrial proposes.
Mobility-Enabled Edge Server Selection for Multi-User Composite Services
Authors: Zhang Wenming , Zhang Yiwen , Wu Qilin , Peng Kai
Published: August 2019

In mobile edge computing, a set of edge servers is geographically deployed near the mobile users such that accessible computing capacities and services can be provided to users with low latency. Due to user’s mobility, one fundamental and critical problem in mobile edge computing is how to select edge servers for many mobile users so that the total waiting time is minimized. In this paper, we propose a multi-user waiting time computation model about composite services and show the resource contention of the edge server among mobile users. Then, we introduce a novel and optimal Multi-user Edge server Selection method based on Particle swarm optimization (MESP) in mobile edge computing, which selects edge servers for mobile uses in advance within polynomial time. Extensive simulations on a real-world data-trace show that the MESP algorithm can effectively reduce the total waiting time compared with traditional approaches.
Parameters and Branching Auto-Pulses in a Fluid Channel with Active Walls
Authors: Strunin Dmitry , Ahmed Fatima
Published: August 2019

We present numerical solutions of the semi-phenomenological model of self-propagating fluid pulses (auto-pulses) in the channel branching into two thinner channels, which simulates branching of a hypothetical artificial artery. The model is based on the lubrication theory coupled with elasticity and has the form of a single nonlinear partial differential equation with respect to the displacement of the elastic wall as a function of the distance along the channel and time. The equation is solved numerically using the 1D integrated radial basis function network method. Using homogeneous boundary conditions on the edges of space domain and continuity condition at the branching point, we obtained and analyzed solutions in the form of auto-pulses penetrating through the branching point from the thick channel into the thin channels. We evaluated magnitudes of the phenomenological coefficients responsible for the active motion of the walls in the model.
Phytochemical Characteristics and Antimicrobial Activity of Australian Grown Garlic (Allium Sativum L.) Cultivars
Authors: Phan Anh , Netzel Gabriele , Chhim Panhchapor , Netzel Michael , Sultanbawa Yasmina
Published: August 2019

This study systematically evaluated the main bioactive compounds and associated biological properties of two Australian grown garlic cultivars and commercial non-Australian grown garlic (for comparison purposes only). Additionally, the distribution of bioactive compounds in garlic skin and clove samples was determined to obtain a better understanding of the potential biological functionality of the different garlic parts. The identification and quantification of bioactive compounds was performed by ultra-high performance liquid chromatography with mass spectrometry and photodiode array detection (UHPLC-PDA-MS). A principal component analysis was applied to assess the correlation between the determined bioactive compounds and antioxidant capacity as well as antimicrobial activity. The content of phenolic compounds (free and bound forms) in the garlic skin samples was significantly (p < 0.05) higher than that of the garlic cloves, and was also higher (p < 0.05) in the Australian grown cultivars compared to the commercial non-Australian grown garlic. Anthocyanins were found in the skin samples of the Australian grown garlic cultivars. The organosulfur compounds were higher (p < 0.05) in the cloves compared to the skin samples and higher (p < 0.05) in the Australian grown cultivars compared to the studied commercial sample. As the richer source of bioactive compounds, the Australian grown garlic cultivars exhibited a significantly (p < 0.05) higher antioxidant capacity and stronger (p < 0.05) antimicrobial activity than the commercial non-Australian grown garlic. The potential of garlic cultivars rich in bioactive compounds for domestic and industrial applications, e.g., condiment and natural food preservative, should be explored further.
Lipid Oxidation in Emulsions Fortified with Iron-Loaded Alginate Beads
Authors: Cengiz Alime , Schroën Karin , Berton-Carabin Claire
Published: August 2019

The potential use of iron-loaded alginate beads to fortify oil-in-water (O/W) emulsions was studied. Iron-loaded alginate beads with different sizes (0.65, 0.84, 1.5 and 2 mm) were produced by ionic gelation with calcium chloride, leading to 81% encapsulation efficiency (EE) of ferrous sulfate. These beads were added to O/W emulsions to investigate their effect on lipid oxidation. The use of iron-loaded alginate beads inhibited lipid oxidation in emulsions, compared to a control emulsion with the same concentration of free ferrous sulfate in the continuous phase, but did not totally prevent it. Results obtained with scanning electron microscopy and energy dispersive X-ray spectroscopy (EDX) analysis showed that some reactive iron was present at the surface of the beads. Oxidation of the lipid droplets was slightly higher for smaller alginate beads, suggesting that the reaction could be linked to the total bead surface. When covering iron-loaded beads with an extra layer of alginate, lipid oxidation was inhibited, which confirmed the role of reactive surface-bound iron. This study shows that the location of iron within the encapsulates plays a crucial role in the chemical stability of fortified foods and should be taken as a starting point in the design of iron-fortified food products.
How Fermentation Affects the Antioxidant Properties of Cereals and Legumes
Authors: Verni Michela , Verardo Vito , Rizzello Carlo
Published: August 2019

The major role of antioxidant compounds in preserving food shelf life, as well as providing health promoting benefits, combined with the increasing concern towards synthetic antioxidants, has led the scientific community to focus on natural antioxidants present in food matrices or resulting from microbial metabolism during fermentation. This review aims at providing a comprehensive overview of the effect of fermentation on the antioxidant compounds of vegetables, with emphasis on cereals- and legumes- derived foods. Polyphenols are the main natural antioxidants in food. However, they are often bound to cell wall, glycosylated, or in polymeric forms, which affect their bioaccessibility, yet several metabolic activities are involved in their release or conversion in more active forms. In some cases, the antioxidant properties in vitro, were also confirmed during in vivo studies. Similarly, bioactive peptides resulted from bacterial and fungal proteolysis, were also found to have ex vivo protective effect against oxidation. Fermentation also influenced the bioaccessibility of other compounds, such as vitamins and exopolysaccharides, enabling a further improvement of antioxidant activity in vitro and in vivo. The ability of fermentation to improve food antioxidant properties strictly relies on the metabolic activities of the starter used, and to further demonstrate its potential, more in vivo studies should be carried out.
Promising Tropical Fruits High in Folates
Authors: Striegel Lisa , Weber Nadine , Dumler Caroline , Chebib Soraya , Netzel Michael E. , Sultanbawa Yasmina , Rychlik Michael
Published: August 2019

As the popularity of tropical fruits has been increasing consistently during the last few decades, nutritional and health-related data about these fruits have been gaining more and more interest. Therefore, we analyzed 35 samples of tropical fruits and vegetables with respect to folate content and vitamer distribution in this study. The fruits and vegetables were selected by their availability in German supermarkets and were grouped according to their plant family. All fruits and vegetables were lyophilized and analyzed by stable isotope dilution assay (SIDA) and liquid chromatography mass spectrometry (LC-MS/MS). The results vary from 7.82 ± 0.17 µg/100 g in the horned melon to 271 ± 3.64 µg/100 g in the yellow passion fruit. The yellow passion fruit is a good source for meeting the recommended requirements, as just 110 g are needed to cover the recommended daily intake of 300 µg folate for adults; however, longan fruits, okras, pete beans, papayas, mangos, jack fruits, and feijoas are also good sources of folates. In conclusion, the study gives a good overview of the total folate content in a broad range of tropical fruits and vegetables and shows that some of these fruits definitely have the potential to improve the supply of this critical vitamin.
Analysis of the Acid Detergent Fibre Content in Turnip Greens and Turnip Tops (Brassica rapa L. Subsp. rapa) by Means of Near-Infrared Reflectance
Authors: Obregón-Cano Sara , Moreno-Rojas Rafael , Jurado-Millán Ana , Cartea-González María , De Haro-Bailón Antonio
Published: August 2019

Standard wet chemistry analytical techniques currently used to determine plant fibre constituents are costly, time-consuming and destructive. In this paper the potential of near-infrared reflectance spectroscopy (NIRS) to analyse the contents of acid detergent fibre (ADF) in turnip greens and turnip tops has been assessed. Three calibration equations were developed: in the equation without mathematical treatment the coefficient of determination (R2) was 0.91, in the first-derivative treatment equation R2 = 0.95 and in the second-derivative treatment R2 = 0.96. The estimation accuracy was based on RPD (the ratio between the standard deviation and the standard error of validation) and RER (the ratio between the range of ADF of the validation as a whole and the standard error of prediction) of the external validation. RPD and RER values were of 2.75 and 9.00 for the treatment without derivative, 3.41 and 11.79 with first-derivative, and 3.10 and 11.03 with second-derivative. With the acid detergent residue spectrum the wavelengths were identified and associated with the ADF contained in the sample. The results showed a great potential of NIRS for predicting ADF content in turnip greens and turnip tops.
Structurally Different Pectic Oligosaccharides Produced from Apple Pomace and Their Biological Activity In Vitro
Authors: Wilkowska Agnieszka , Nowak Adriana , Antczak-Chrobot Aneta , Motyl Ilona , Czyżowska Agata , Paliwoda Anna
Published: August 2019

This study set out to identify the composition and the biological activity of pectin-derived oligosaccharides (POS) generated from mild acid or enzymatic hydrolysis of apple pomace (AP). The effect of the polymerization of the structural units of POS contained in the AP hydrolysate on the growth and metabolism of microbiota from the human gastrointestinal tract and the adhesion of lactic acid bacteria (LAB) or pathogens to human gut epithelial cells was investigated in vitro. Mild acid hydrolysis followed by pectinolysis with Rohapect MaPlusT yielded the highest concentration of POS. In contrast, pure enzymatic processing of the AP performed with a mixed preparation of cellulase and Rohapect MaPlusT resulted in 1.8-fold lower overall POS. The concentration of higher-order oligosaccharides (degree of polymerization (DP) 7–10), however, was 1.7-fold higher. The increased ratio of higher-order oligosaccharides caused an increase in the bifidogenic effect, as well as affecting the amount and nature of short-chain fatty acid produced. Inhibition of Enterobacteriaceae was also observed. The strongest stimulation of LAB adhesion to the human epithelial cells occurred in the presence of the preparation containing the highest concentration of higher-order oligosaccharides. The fecal bacteria and pathogens showed much weaker adhesion to intestinal cells in the presence of all the tested AP hydrolysates. Both of the tested POS preparations, containing structurally different oligosaccharides (DPs 2–10 with different ratios of higher-order oligosaccharides), have the potential to be used as prebiotics for humans and animals. They stimulate bowel colonization with lactic acid bacteria and inhibit the development of infections caused by pathogens.
Strategy towards Replacing Pork Backfat with a Linseed Oleogel in Frankfurter Sausages and Its Evaluation on Physicochemical, Nutritional, and Sensory Characteristics
Authors: Franco Daniel , Martins Artur , López-Pedrouso María , Purriños Laura , Cerqueira Miguel , Vicente António , Pastrana Lorenzo , Zapata Carlos , Lorenzo José
Published: August 2019

Different health institutions from western countries ha–ve recommended a diet higher in polyunsaturated fats, especially of the n-3 family. However, this is not a trivial task, especially for meat-processing sectors. The objective of this work was to assess the influence of replacing pork backfat with linseed oleogel on the main quality parameters of frankfurters. The frankfurters were formulated by the pork backfat replacement of 0% (control), 25% (SF-25), and 50% (SF-50), using a linseed oleogel gelled with beeswax. The determination of quality parameters (pH, colour, chemical composition, and texture parameters), the fatty acid profile, and the sensory evaluation was carried out for each batch. The fatty acid profile was substantially improved, and the saturated fatty acid (SFA) content was reduced from 35.15g/100g in control sausages to 33.95 and 32.34g/100 g in SF-25 and SF-50, respectively, and more balanced ratios n-6/n-3 were achieved. In addition, the sausages with linseed oleogel also decreased the cholesterol content from 25.08 mg/100 g in control sausages to 20.12 and 17.23 mg/100 g in SF-25 and SF-50, respectively. It may therefore be concluded that these innovative meat products are a healthier alternative. However, sensory parameters should be improved in order to increase consumer acceptability, and further research is needed.
Gene‒Prostate-Specific-Antigen-Guided Personalized Screening for Prostate Cancer
Authors: Yang Teng-Kai , Chuang Pi-Chun , Yen Amy Ming-Fang , Chen Hsiu-Hsi , Chen Sam Li-Sheng
Published: August 2019

(1) Background: A simulation approach for prostate cancer (PrCa) with a prostate-specific antigen (PSA) test incorporating genetic information provides a new avenue for the development of personalized screening for PrCa. Going by the evidence-based principle, we use the simulation method to evaluate the effectiveness of mortality reduction resulting from PSA screening and its utilization using a personalized screening regime as opposed to a universal screening program. (2) Methods: A six-state (normal, over-detected, low-grade, and high-grade PrCa in pre-clinical phase, and low-grade and high-grade PrCa in clinical phase) Markov model with genetic and PSA information was developed after a systematic review of genetic variant studies and dose-dependent PSA studies. This gene‒PSA-guided model was used for personalized risk assessment and risk stratification. A computer-based simulated randomized controlled trial was designed to estimate the reduction of mortality achieved by three different screening methods, personalized screening, universal screening, and a non-screening group. (3) Results: The effectiveness of PrCa mortality reduction for a personalized screening program compared to a non-screening group (22% (9%‒33%)) was similar to that noted in the universal screening group (20% (7%‒21%). However, a personalized screening program could dispense with 26% of unnecessary PSA testing, and avoid over-detection by 2%. (4) Conclusions: Gene‒PSA-guided personalized screening for PrCa leads to fewer unnecessary PSA tests without compromising the benefits of mortality reduction (as happens with the universal screening program).
Opportunities and Challenges in Interpreting and Sharing Personal Genomes
Authors: Rubin Irit R. , Glusman Gustavo
Published: August 2019

The 2019 “Personal Genomes: Accessing, Sharing and Interpretation” conference (Hinxton, UK, 11–12 April 2019) brought together geneticists, bioinformaticians, clinicians and ethicists to promote openness and ethical sharing of personal genome data while protecting the privacy of individuals. The talks at the conference focused on two main topic areas: (1) Technologies and Applications, with emphasis on personal genomics in the context of healthcare. The issues discussed ranged from new technologies impacting and enabling the field, to the interpretation of personal genomes and their integration with other data types. There was particular emphasis and wide discussion on the use of polygenic risk scores to inform precision medicine. (2) Ethical, Legal, and Social Implications, with emphasis on genetic privacy: How to maintain it, how much privacy is possible, and how much privacy do people want? Talks covered the full range of genomic data visibility, from open access to tight control, and diverse aspects of balancing benefits and risks, data ownership, working with individuals and with populations, and promoting citizen science. Both topic areas were illustrated and informed by reports from a wide variety of ongoing projects, which highlighted the need to diversify global databases by increasing representation of understudied populations.
Mountain Landslides: Monitoring, Modeling, and Mitigation
Authors: Corsini Alessandro , Borgatti Lisa
Published: August 2019

This editorial paper summarizes the contents of the papers included in the Special Issue “Mountain Landslides: Monitoring, Modeling, and Mitigation”. The Special Issue provides an overview of methodological papers, as well as some innovative research carried out in the field and in the lab. Even if most papers adopted an integrated approach, sections representing the three research issues outlined in the title can be drawn: the first deals with monitoring, the second focuses on modeling, and the third is related to mitigation. Regardless of the section, the papers included in this special issue put forward methodological and practical implications that, more than likely, can stimulate further research efforts and support the stakeholders to gain better knowledge of landslide hazards in mountain environments, with an aim to tackle the urgent issue of sustainable development in times of global change that can affect landslide occurrences in mountain chains of the world.
Utilization of Traditional Chinese Medicine Practitioners in Later Life in Mainland China
Authors: Aw Jessica Yi Han , Sbirakos Yiengprugsawan Vasoontara , Gong Cathy Honge
Published: August 2019

Mainland China is one of the world’s most rapidly aging countries, and yet there is very limited literature on traditional Chinese medicine (TCM) use in older individuals. This study aimed to determine the national and provincial prevalence of TCM practitioner utilization in later life and associated factors. We used World Health Organization China Study on Global Aging and Adult Health Wave 1 data to determine descriptive statistics of the study population of participants aged 50 years and over. Multivariate logistic regression was conducted controlling for sociodemographic and health factors. A total of 14% of participants utilized a TCM practitioner, and the prevalence of utilization varied significantly by locality. Utilization was more likely in participants living in rural areas [adjusted odds ratio (OR) = 12.96; p < 0.001], Hubei (OR = 7.17; p < 0.001), or Shandong provinces (OR = 4.21; p < 0.001) and being diagnosed with chronic lung disease (OR = 1.97; p = 0.005). Hence, rurality, provincial influence, and chronic lung diseases are significant factors associated with TCM practitioner utilization among older individuals in China. These findings may inform policy for preservation and development of TCM nationally as well as its sustainability in an increasingly aging society.
Drug-Induced Sleep Endoscopy: Clinical Application and Surgical Outcomes
Authors: De Vito Andrea , Cammaroto Giovanni , Chong Khai Beng , Carrasco-Llatas Marina , Vicini Claudio
Published: August 2019

The visualization of the level and pattern of apnea and hypopnea events is of pivotal importance in the diagnosis and therapeutic decision-making for sleep-disordered breathing (SDB). There are numerous techniques available to assess upper airway obstruction, which include imaging, acoustic analysis, pressure transducer recording, and endoscopic evaluation. Drug-induced sleep endoscopy (DISE) is a diagnostic tool that allows the dynamic, three-dimensional evaluation of the patterns of vibration and collapse of the upper airway of SDB patients. DISE may change the initial surgical planning in a high percentage of cases. A universally accepted and methodologically standardized DISE could provide significant insight into its role to improve surgical outcomes. However, up to now the ideal DISE protocol remains an open question.
Using 3D Spatial Visualisation to Interpret the Coverage of Anti-Aircraft Batteries on a World War II Battlefield
Authors: Spennemann Dirk , Poynter Craig
Published: August 2019

Heritage Building Information Modeling (HBIM) focuses on the documentation and visualization of heritage properties which are confined in their permanent terrestrial space. This paper extended the concept of Heritage Building Information Modeling to the airspace above the sites. It presented a methodology for the 3D spatial visualisation of the aerial space controlled by anti-aircraft (AA) guns, taking into account the masking effects of the underlying terrain and the technological capabilities of the guns (rate of fire, projectile weight, etc.). The tool permits a nuanced analysis of the interplay between attacking aircraft and the siting of anti-aircraft guns and thus, allows for the analysis of the cultural landscape of World War II-era battle fields, which has to take into account the influence of aerial warfare. The applicability was illustrated by the case example of the Japanese WWII base on Kiska (Aleutian Islands).
Assessing Agreement in Exposure Classification between Proximity-Based Metrics and Air Monitoring Data in Epidemiology Studies of Unconventional Resource Development
Authors: Wendt Hess Judy , Bachler Gerald , Momin Fayaz , Sexton Krystal
Published: August 2019

Recent studies of unconventional resource development (URD) and adverse health effects have been limited by distance-based exposure surrogates. Our study compared exposure classifications between air pollutant concentrations and “well activity” (WA) metrics, which are distance-based exposure proxies used in Marcellus-area studies to reflect variation in time and space of residential URD activity. We compiled Pennsylvania air monitoring data for benzene, carbon monoxide, nitrogen dioxide, ozone, fine particulates and sulfur dioxide, and combined this with data on nearly 9000 Pennsylvania wells. We replicated WA calculations using geo-coordinates of monitors to represent residences and compared exposure categories from air measurements and WA at the site of each monitor. There was little agreement between the two methods for the pollutants included in the analysis, with most weighted kappa coefficients between −0.1 and 0.1. The exposure categories agreed for about 25% of the observations and assigned inverse categories 16%–29% of the time, depending on the pollutant. Our results indicate that WA measures did not adequately distinguish categories of air pollutant exposures and employing them in epidemiology studies can result in misclassification of exposure. This underscores the need for more robust exposure assessment in future analyses and cautious interpretation of these existing studies.
Where Do People Vape? Insights from Twitter Data
Authors: Majmundar Anuja , Allem Jon-Patrick , Cruz Tess Boley , Unger Jennifer B.
Published: August 2019

Background: Emerging evidence suggests that exposure to secondhand and thirdhand aerosol from electronic cigarettes may have serious health risks including respiratory and cardiovascular diseases. Social media data can help identify common locations referenced in vaping-related discussions and offer clues about where individuals vape. These insights can strengthen current tobacco regulations and prioritize new policies to improve public health. This study identified commonly referenced locations in vaping-related discussions on Twitter in 2018. Methods: Vaping-related posts to Twitter were obtained from 1 January 2018 to 31 December 2018. Rule-based classifiers categorized each Twitter post into 11 location-related categories (social venues, living spaces, stores, modes of transportation, schools, workplaces, healthcare offices, eateries, correctional facilities, religious institutions, and miscellaneous) using a data dictionary of location-related keywords (n = 290,816). Results: The most prevalent category was social venues (17.9%), followed by living spaces (16.7%), stores (15.9%), modes of transportation (15.5%), schools (14.9%), and workplaces (11.9%). Other categories pertained to: healthcare offices (2.0%), eateries (1.2%), correctional facilities (0.7%), and religious institutions (0.4%). Conclusion: This study suggests that locations related to socialization venues may be priority areas for future surveillance and enforcement of smoke-free air policies. Similarly, development and enforcement of similar policies at workplaces, schools and multi-unit housing may curb exposure to secondhand and thirdhand aerosol among the public.
Measurement of Key Constructs in a Holistic Framework for Assessing Self-Management Effectiveness of Pediatric Asthma
Authors: Rangachari Pavani , May Kathleen R. , Stepleman Lara M. , Tingen Martha S. , Looney Stephen , Liang Yan , Rockich-Winston Nicole , Rethemeyer R. Karl
Published: August 2019

The 2007 U.S. National Institutes of Health EPR-3 guidelines emphasize the importance creating a provider-patient partnership to enable patients/families to monitor and take control of their asthma, so that treatment can be adjusted as needed. However, major shortfalls continue to be reported in provider adherence to EPR-3 guidelines. For providers to be more engaged in asthma management, they need a comprehensive set of resources for measuring self-management effectiveness of asthma, which currently do not exist. In a previously published article in the Journal of Asthma and Allergy, the authors conducted a literature review, to develop a holistic framework for understanding self-management effectiveness of pediatric asthma. The essence of this framework, is that broad socioecological factors can influence self-agency (patient/family activation), to impact self-management effectiveness, in children with asthma. A component of socio-ecological factors of special relevance to providers, would be the quality of provider-patient/family communication on asthma management. Therefore, the framework encompasses three key constructs: (1) Provider-patient/family communication; (2) Patient/family activation; and (3) Self-management effectiveness. This paper conducts an integrative review of the literature, to identify existing, validated measures of the three key constructs, with a view to operationalizing the framework, and discussing its implications for asthma research and practice.
Assessing Physical Activity and Sedentary Behavior under Free-Living Conditions: Comparison of Active Style Pro HJA-350IT and ActiGraphTM GT3X+
Authors: Yano Shohei , Koohsari Mohammad Javad , Shibata Ai , Ishii Kaori , Mavoa Suzanne , Oka Koichiro
Published: August 2019

Various accelerometers have been used in research measuring physical activity (PA) and sedentary behavior (SB). This study compared two triaxial accelerometers—Active style Pro (ASP) and ActiGraph (AG)—in measuring PA and SB during work and nonwork days in free-living conditions. A total of 50 working participants simultaneously wore these two accelerometers on one work day and one nonwork day. The difference and agreement between the ASP and AG were analyzed using paired t-tests, Bland–Altman plots, and intraclass coefficients, respectively. Correction factors were provided by linear regression analysis. The agreement in intraclass coefficients was high among all PA intensities between ASP and AG. SB in the AG vertical axis was approximately 103 min greater than ASP. Regarding moderate-to-vigorous-intensity PA (MVPA), ASP had the greatest amount, followed by AG. There were significant differences in all variables among these devices across all day classifications, except for SB between ASP and AG vector magnitude. The correction factors decreased the differences of SB and MVPA. PA time differed significantly between ASP and AG. However, SB and MVPA differences between these two devices can be decreased using correction factors, which are useful methods for public health researchers.
The Importance of Community Engagement and Research Translation within the NIEHS Superfund Research Program
Authors: Trottier Brittany A. , Carlin Danielle J. , Heacock Michelle L. , Henry Heather F. , Suk William A.
Published: August 2019

The National Institute of Environmental Health Sciences Superfund Research Program (SRP) funds university-based, solution-oriented research to understand how hazardous substances contribute to disease and how to prevent exposures to these hazardous substances. A unique aspect of the SRP is that, beyond the biomedical, environmental sciences, and engineering research projects, SRP-funded centers are required to include community engagement to build partnerships with affected communities and research translation to communicate and facilitate the use of research findings. The SRP views both as effective ways to inform and advance science for protection of public health. The purpose of community engagement within the centers is to ensure bidirectional communication between the researchers and the community, identify best practices and activities in community engagement for prevention and intervention activities, enhance knowledge, and support the needs of the communities impacted by hazardous waste sites. The SRP views research translation as communicating and facilitating the use of research findings emanating from the center in a manner most appropriate for their application and for the advancement of a center’s research objectives. The SRP has a strong history of seeking opportunities to work with communities and stakeholders, by translating and sharing research findings in an impactful and informative manner with long-lasting benefits to improve public health.
Incidence of the Acute Symptom of Chronic Periodontal Disease in Patients Undergoing Supportive Periodontal Therapy: A 5-Year Study Evaluating Climate Variables
Authors: Saho Hikari , Takeuchi Noriko , Ekuni Daisuke , Morita Manabu
Published: August 2019

Although patients under supportive periodontal therapy (SPT) have a stable periodontal condition, the acute symptom of chronic periodontal disease occasionally occurs without a clear reason. Therefore, in the present study, to obtain a better understanding of this relationship in patients undergoing SPT, we hypothesized that the acute symptom of chronic periodontal disease might be affected by climate factors. We conducted a questionnaire study and carried out oral examinations on patients undergoing SPT who had been diagnosed as having the acute symptom of chronic periodontal disease. We collected climate data from the local climate office in Okayama city, Japan. We predicted parameters that affect the acute symptom of chronic periodontal disease with unidentified cause and divided patients into high and low groups in terms of climate predictors. Then we defined the cut-off values of parameters showing significant differences in the incidence of the acute symptom of chronic periodontal disease. The incidence of the acute symptom of chronic periodontal disease with unidentified cause was significantly different when the cases were classified according to the maximum hourly decrease in barometric pressure (1.5 and 1.9 hPa) (p = 0.04 and p = 0.03, respectively). This suggests that climate variables could be predictors of the acute symptom of chronic periodontal disease. Therefore, gaining a better understanding of these factors could help periodontal patients undergoing SPT prepare to avoid the acute symptom of chronic periodontal disease.
African American Exposure to Prescribed Fire Smoke in Georgia, USA
Authors: Johnson Gaither Cassandra , Afrin Sadia , Garcia-Menendez Fernando , Odman M. Talat , Huang Ran , Goodrick Scott , Ricardo da Silva Alan
Published: August 2019

Our project examines the association between percent African American and smoke pollution in the form of prescribed burn-sourced, fine particulate matter (PM2.5) in the U.S. state of Georgia for 2018. (1) Background: African Americans constitute 32.4% of Georgia’s population, making it the largest racial/ethnic minority group in the state followed by Hispanic Americans at 9.8%. African Americans, Hispanic Americans, and lower wealth groups are more likely than most middle and upper income White Americans to be exposed to environmental pollutants. This is true because racial and ethnic minorities are more likely to live in urban areas where pollution is more concentrated. As a point of departure, we examine PM2.5 concentrations specific to prescribed fire smoke, which typically emanates from fires occurring in rural or peri-urban areas. Two objectives are specified: a) examine the association between percent African American and PM2.5 concentrations at the census tract level for Georgia, and b) identify emitters of PM2.5 concentrations that exceed National Ambient Air Quality Standards (NAAQS) for the 24-h average, i. e., >35 µg/m3. (2) Methods: For the first objective, we estimate a spatial Durbin error model (SDEM) where pollution concentration (PM2.5) estimates for 1683 census tracts are regressed on percent of the human population that is African American or Hispanic; lives in mobile homes; and is employed in agriculture and related occupations. Also included as controls are percent evergreen forest, percent mixed evergreen/deciduous forest, and variables denoting lagged explanatory and error variables, respectively. For the second objective, we merge parcel and prescribed burn permit data to identify landowners who conduct prescribed fires that produce smoke exceeding the NAAQS. (3) Results: Percent African American and mobile home dweller are positively related to PM2.5 concentrations; and government and non-industrial private landowners are the greatest contributors to exceedance levels (4) Conclusions: Reasons for higher PM2.5 concentrations in areas with higher African American and mobile home percent are not clear, although we suspect that neither group is a primary contributor to prescribed burn smoke but rather tend to live proximate to entities, both public and private, that are. Also, non-industrial private landowners who generated prescribed burn smoke exceeding NAAQS are wealthier than others, which suggests that African American and other environmental justice populations are less likely to contribute to exceedance levels in the state.
Morehouse Choice Accountable Care Organization and Education System (MCACO-ES): Integrated Model Delivering Equitable Quality Care
Authors: Brown Michelle , Ofili Elizabeth O. , Okirie Debbie , Pemu Priscilla , Franklin Cheryl , Suk Yoon , Quarshie Alexander , Mubasher Mohamed , Sow Charles , Montgomery Rice Valerie , Williams David , Brooks Michael , Alema-Mensah Ernest , Mack Dominic , Dawes Daniel
Published: August 2019

Accountable Care Organizations (ACOs) seek sustainable innovation through the testing of new care delivery methods that promote shared goals among value-based health care collaborators. The Morehouse Choice Accountable Care Organization and Education System (MCACO-ES), or (M-ACO) is a physician led integrated delivery model participating in the Medicare Shared Savings Program (MSSP) offered through the Centers for Medicare and Medicaid Services (CMS) Innovation Center. The MSSP establishes incentivized, performance-based payment models for qualifying health care organizations serving traditional Medicare beneficiaries that promote collaborative efficiency models designed to mitigate fragmented and insufficient access to health care, reduce unnecessary cost, and improve clinical outcomes. The M-ACO integration model is administered through participant organizations that include a multi-site community based academic practice, independent physician practices, and federally qualified health center systems (FQHCs). This manuscript aims to present a descriptive and exploratory assessment of health care programs and related innovation methods that validate M-ACO as a reliable simulator to implement, evaluate, and refine M-ACO’s integration model to render value-based performance outcomes over time. A part of the research approach also includes early outcomes and lessons learned advancing the framework for ongoing testing of M-ACO’s integration model across independently owned, rural, and urban health care locations that predominantly serve low-income, traditional Medicare beneficiaries, (including those who also qualify for Medicaid benefits (also referred to as “dual eligibles”). M-ACO seeks to determine how integration potentially impacts targeted performance results. As a simulator to test value-based innovation and related clinical and business practices, M-ACO uses enterprise-level data and advanced analytics to measure certain areas, including: 1) health program insight and effectiveness; 2) optimal implementation process and workflows that align primary care with specialists to expand access to care; 3) chronic care management/coordination deployment as an effective extender service to physicians and patients risk stratified based on defined clinical and social determinant criteria; 4) adoption of technology tools for patient outreach and engagement, including a mobile application for remote biometric monitoring and telemedicine; and 5) use of structured communication platforms that enable practitioner engagement and ongoing training regarding the shift from volume to value-based care delivery.
Coping with a Disruptive Life Caused by Obstetric Fistula: Perspectives from Malawian Women
Authors: Changole Josephine , Thorsen Viva , Trovik Jone , Kafulafula Ursula , Sundby Johanne
Published: August 2019

Background: The main symptom of obstetric fistula is urinary and or fecal incontinence. Incontinence, regardless of the type is debilitating, socially isolating, and psychologically depressing. The objective of this study was to explore the strategies that women with obstetric fistula in Malawi use to manage it and its complications. Methods: A subset of data from a study on experiences of living with obstetric fistula in Malawi was used to thematically analyze the strategies used by women to cope with their fistula and its complications. The data were collected using semi-structured interviews. Nvivo 10 was used to manage data. Results: Participants used two forms of coping strategies: (1) problem-based coping strategies: restricting fluid intake, avoiding sexual intercourse, using homemade pads, sand, corn flour, a cloth wreathe and herbs, and (2) emotional-based coping strategies: support from their families, children, and through their faith in God. Conclusion: Women living with incontinence due to obstetric fistula employ different strategies of coping, some of which conflict with the advice of good bladder management. Therefore, these women need more information on how best they can self-manage their condition to ensure physical and emotional comfort.
What Can We Obtain from Mental Health Care? The Dynamics of Physical and Mental Health
Authors: Yoon Sung-Joo
Published: August 2019

This study analyzes the dynamic interaction of an individual’s physical and mental health using the German Socio-Economic Panel and the Cross-National Equivalent File of Germany. Its main objective is to find a way to reduce people’s health expenditure by examining the magnitude of the interdependence between physical and mental health. For the analysis, this study develops a dynamic correlated random effects model. We create two aggregate health measures (aggregate physical health and aggregate mental health) with four submeasures each, which provides a better understanding of changes in an individual’s health status by capturing additional information that cannot be analyzed at the aggregate level. There is clear evidence that the persistence of a mental health condition is less than that of a physical health condition. Moreover, the impact of previous mental health on current physical health is greater than that of previous physical health on current mental health. This suggests that individuals can reduce their expenditures on physical health problems by focusing on the treatment of mental problems when they first arise. Finally, the Government’s attention and support toward mental health care would lead to a reduction in health expenditures and eventually improve the sustainability of the nation’s health system.
Performance of Fish Farms in Vietnam–Does Financial Access Help Improve Their Cost Efficiency?
Authors: Ngo Thanh , Vu Hung V. , Ho Huong , Dao Thuy T. T. , Nguyen Hai T. H.
Published: August 2019

For a common small- to medium-sized fish farm in an agricultural-based economy, monitoring costs is very important, since financial constraints are always a problem for these farmers. This will be thus easier if the farmers can get access to external funds. This paper used data envelopment analysis (DEA) to examine the technical efficiency, cost efficiency and allocative efficiency of 639 fish farms in the Red River Delta (RRD) in Vietnam in 2018 to see how fish farmers control their costs and if financial access can really help in this matter. We found that these fish farms were very inefficient, meaning that they did not succeed in monitoring and allocating their costs and resources. Among the factors that could improve their efficiency, we found that developing the rural banking system to provide more financial access for RRD fish farms is an important solution.
TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation
Authors: Hasan Amal , Akhter Nadeem , Al-Roub Areej , Thomas Reeby , Kochumon Shihab , Wilson Ajit , Koshy Merin , Al-Ozairi Ebaa , Al-Mulla Fahd , Ahmad Rasheed
Published: August 2019

Elevated levels of IL-8 (CXCL8) in obesity have been linked with insulin resistance and type 2 diabetes (T2D). The mechanisms that lead to the profound production of IL-8 in obesity remains to be understood. TNF-α and saturated free fatty acids (FFAs) are increased in obese humans and correlate with insulin resistance. Hence, we sought to investigate whether the cooccurrence of TNF-α and FFAs led to increase the production of IL-8 by human monocytes. We found that co-stimulation of human monocytes with palmitate and TNF-α led to increased IL-8 production as compared to those stimulated with palmitate or TNF-α alone. The synergistic production of IL-8 by TNF-α/palmitate was suppressed by neutralizing anti- Toll like receptor 4 (TLR4) antibody and by genetic silencing of TLR4. Both MyD88-deficient and MyD88-competent cells responded comparably to TNF-α/Palmitate. However, TIR-domain-containing adapter-inducing interferon (TRIF) inhibition or interferon regulatory transcription factor 3 (IRF3) knockdown partly blocked the synergistic production of IL-8. Our human data show that increased adipose tissue TNF-α expression correlated positively with IL-8 expression (r = 0.49, P = 0.001). IL-8 and TNF-α correlated positively with macrophage markers including CD68, CD163 and CD86 in adipose tissue. These findings suggest that the signaling cross-talk between saturated fatty acid palmitate and TNF-α may be a key driver in obesity-associated chronic inflammation via an excessive production of IL-8.
Emerging Role of Genetic Alterations Affecting Exosome Biology in Neurodegenerative Diseases
Authors: Riva Paola , Battaglia Cristina , Venturin Marco
Published: August 2019

The abnormal deposition of proteins in brain tissue is a common feature of neurodegenerative diseases (NDs) often accompanied by the spread of mutated proteins, causing neuronal toxicity. Exosomes play a fundamental role on their releasing in extracellular space after endosomal pathway activation, allowing to remove protein aggregates by lysosomal degradation or their inclusion into multivesicular bodies (MVBs), besides promoting cellular cross-talk. The emerging evidence of pathogenic mutations associated to ND susceptibility, leading to impairment of exosome production and secretion, opens a new perspective on the mechanisms involved in neurodegeneration. Recent findings suggest to investigate the genetic mechanisms regulating the different exosome functions in central nervous system (CNS), to understand their role in the pathogenesis of NDs, addressing the identification of diagnostic and pharmacological targets. This review aims to summarize the mechanisms underlying exosome biogenesis, their molecular composition and functions in CNS, with a specific focus on the recent findings invoking a defective exosome biogenesis as a common biological feature of the major NDs, caused by genetic alterations. Further definition of the consequences of specific genetic mutations on exosome biogenesis and release will improve diagnostic and pharmacological studies in NDs.