bluuebunny/crossref_metadata_2025 huggingface dataset:
Is The transition to digital era here? --- A cross sectional study amongst Dental Practitioners vis-à-vis the usage of digital imaging in Bhopal
Authors: Sathe Dr.Rashmi
Published: September 2024

Background: Scientific evidence supports the idea that transitioning from conventional to digital radiography is now essential since it reduces exposure to ionizing radiation.  The primary aim of this study was to assess the attitude, awareness and knowledge of dental practitioners of Bhopal, to the use of digital radiography. The objectives were identifying reasons for   incorporating digital imaging, and the attitude towards wanting to make a transition from conventional method. Methods: A cross-sectional survey was conducted amongst the private dental practitioners in Bhopal, Madhya Pradesh. A structured questionnaire was shared using Google platform. Results: Out of the 350 respondents, 279 (79.71%) reported using digital radiography, with 32.85% believing that the benefits of digital radiography were the decreased patient exposure, improved image, long-term cost savings, and improved image quality in particular to see the root canals and measure bone loss. Conclusion: A majority of respondents were positively influenced by the usage of digital imaging in their routine practice. 
Keywords: Digital imaging, dental practitioner, dosage, radiography.
Background: Scientific evidence supports the idea that transitioning from conventional to digital radiography is now essential since it reduces exposure to ionizing radiation.  The primary aim of this study was to assess the attitude, awareness and knowledge of dental practitioners of Bhopal, to the use of digital radiography. The objectives were identifying reasons for   incorporating digital imaging, and the attitude towards wanting to make a transition from conventional method. Methods: A cross-sectional survey was conducted amongst the private dental practitioners in Bhopal, Madhya Pradesh. A structured questionnaire was shared using Google platform. Results: Out of the 350 respondents, 279 (79.71%) reported using digital radiography, with 32.85% believing that the benefits of digital radiography were the decreased patient exposure, improved image, long-term cost savings, and improved image quality in particular to see the root canals and measure bone loss. Conclusion: A majority of respondents were positively influenced by the usage of digital imaging in their routine practice. 
Keywords: Digital imaging, dental practitioner, dosage, radiography.
Quantitative evaluation of the evolution of the ecohydrological regime and its drivers in the Han River Basin
Authors: Wang Hongxiang , Ye Handong , Yuan Weiqi , Cheng Siyuan , Bai Xiangyu , Lan Jiaqi , Ma Yajuan , Wang Gaozhen , Guo Wenxian
Published: September 2024

The hydrological regime of the Han River Basin has changed significantly under the double pressure of climate change and human activities, and the ecosystem's health is facing severe challenges. In this study, the ecohydrological regime of the basin was comprehensively assessed through various statistical methods and ecohydrological indicators. The results showed that the runoff volume of the Han River Basin decreased significantly, with an abrupt change in 1990, and the overall hydrological variability of the basin reached 42%. The ecological surplus decreased, the ecological deficit increased, and the ecological flow was strained for a long time. The optimal ecological flow thresholds for annual, spring, summer, autumn, and winter were 89, 97, 85, 83, and 98%, respectively. Quantitative separation of the effects of climate change and human activities on runoff reduction based on Budyko's hypothesis revealed that human activities were the main factor with a contribution of 59.73%, while precipitation and potential evapotranspiration contributed 31.08 and 9.19%, respectively. The study results can provide a scientific basis for water resource management and ecosystem restoration in the Han River Basin.
Motywy akwatyczne w poezji Wincentego Korab-Brzozowskiego
Authors: Borek Bartłomiej
Published: September 2024

Artykuł stanowi próbę przedstawienia obecności motywów akwatycznych w lirycznej twórczości Wincentego Korab-Brzozowskiego. Mówiąc o żywiole wody obecnej w liryce tego poety, wyeksplikowano i omówiono funkcjonowanie wodnych reprezentantów, takich jak choćby morza, oceanu, strumienia, fontann, łez czy płatków śniegu. Przeprowadzona analiza prowadzić miała do zaakcentowania refleksyjnego charakteru wodnego żywiołu i obecnych tu motywów mare tenebrarum, myśli hinduskiej, narracji o Narcyzie czy Maeterlinckowskich powinowactwach.
Mediatyzacja diabła Wiktoryna Grąbczewskiego czyli Łęczyckie bajanie o Borucie panie. Przyczynek do rozważań nad instrumentalizacją kultury ludowej służącą wzmocnieniu władzy politycznej
Authors: Grzegorzewska Anita
Published: September 2024

Podstawą artykułu jest prozodyczna analiza etiudy filmowej Łęczyckie bajanie o Borucie panie z 1983 r. Film ten stanowi ciekawy przykład mediatyzacji kultury ludowej w PRL, tu będącej remediacją legend o diable Borucie do postaci gatunku filmowego (artystycznego filmu dokumentalnego). Autorka, odwołując się do metodologii komunikatywistycznej, bada ścieżkę lektorską filmu i odpowiada na pytanie, w jaki sposób zjawiska brzmieniowe języka (intonacja, akcent i pauza) oraz natężenie emocji wpływają na komponowanie sensu w filmie. Prozodia jako składnik sensu okazuje się istotną składową w procesie mediatyzacji, rozumianej jako zapośredniczenie przez gatunki audialne i audiowizualne.
Magazyn kryminalny „997” jako przyczynek do mediatyzacji tematyki kryminalnej
Authors: Grzegorzewski Krzysztof
Published: September 2024

Celem opracowania jest analiza i prezentacja procesu remediacji (przetworzenia) tematyki kryminalnej ujętej w dokumentacji policyjnej do postaci telewizyjnego magazynu publicystycznego. Zadania tego po raz pierwszy podjął się w 1986 r. Michał Fajbusiewicz, inicjując produkcję magazynu kryminalnego „997”. Autor opracowania bada i opisuje proces powstawania programu, począwszy od analizy dokumentacji policyjnej jako materiału wyjściowego, przez wszystkie etapy produkcji telewizyjnej, takie jak: tworzenie materiałów filmowych w postaci rekonstrukcji zdarzeń, szeroko rozumiany wywiad dziennikarski, przygotowanie scenariusza programu po rejestrację studyjną. W dalszej części autor odpowiada na pytania, w jaki sposób „997” przyczynił się do mediatyzacji (ściślej: „telewizualizacji” tematyki kryminalnej w dyskursie medialnym, a także jakie były jej cele i skutki.
Rany – otwarcie. Wprowadzenie do monografii twórczości Gregory’ego Whiteheada
Authors: Kowalska-Elkader Natalia
Published: September 2024

Artykuł skupia się wokół twórczości amerykańskiego artysty radiowego Gregory’ego Whiteheada, ze szczególnym uwzględnieniem wczesnego etapu jego twórczości. Wybraną metodą badawczą jest analiza strukturalno-semiotyczna oraz, jako metoda pomocnicza, analiza specyficzna dla medium. Celem artykułu jest przedstawienie i analiza wybranych dzieł artysty oraz wskazanie ich idiosynkratycznych cech. Kluczowymi pojęciami wykorzystywanymi w analizie są interferencja i entropia traktowane jako elementy strukturalne audycji oraz zabiegi mise en abyme.
Plakat jako medium walki o prawa kobiet w Szwajcarii
Authors: Krauze-Pierz Justyna
Published: September 2024

W pierwszej połowie XX wieku, kiedy kobiety w większości krajów europejskich zostały zrównane w prawach obywatelskich z mężczyznami, posiadały prawa wyborcze, a tym samym mogły uczestniczyć w wyborach do organów państwowych i uczestniczyć w życiu politycznym, w Szwajcarii – kolebce nowożytnej demokracji europejskiej – obowiązywała całkiem inna koncepcja roli kobiety, która opierała się głównie na macierzyństwie oraz obowiązkach związanych z wychowaniem i opieką nad dziećmi. W latach 20. i 30. XX wieku, kiedy ich koleżanki w Niemczech i Austrii w pełni korzystały z przysługujących im praw wyborczych, Szwajcarki prowadziły daremną walkę o prawa kobiet i przeciwko ich patriarchalnie zdominowanej pozycji społecznej. Celem niniejszego artykułu jest znalezienie odpowiedzi na pytanie, dlaczego postulaty kobiet w Szwajcarii zostały spełnione tak późno, poszukiwania odpowiedzi na postawione pytanie badawcze skupiają się na medium, za pośrednictwem którego zarówno przeciwnicy, jak i zwolennicy praw wyborczych kobiet wyrażali swoje poglądy na temat aktywnego udziału kobiet w polityce oraz jego konsekwencje dla rodziny i szerzej - społeczeństwa, a tym medium był plakat.
Poczucie wspólnoty w Frankenburger Würfelspiel Eberharda Wolfganga Möllersa
Authors: Moskała Paweł
Published: September 2024

Artykuł opisuje kształtowanie poczucia wspólnoty w Thingspiel Eberharda Wolfganga Möllersa Frankenburger Würfelspiel, który w zamyśle Goebellsa miał być formą teatru masowego o charakterze propagandowo-agitacyjnym. Analizowana sztuka jest ostatnim spektakularnym wydarzeniem scenicznym, które miało miejsce podczas Olimpiady w Berlinie w 1936 r. Referat analizuje tekst przedstawienia i opisuje elementy umożliwiające stworzenie poczucia wspólnoty wśród licznie zgromadzonej publiczności. Opisane zostały m. in. takie części składowe masowej inscenizacji, jak: krajobraz, scenografia, oprawa muzyczna, perspektywa, czy wreszcie ruch sceniczny i bliski kontakt fizyczny pomiędzy widzami, od których naziści oczekiwali aktywnego współuczestnictwa w inscenizacji.
Literatura science fiction Stanisława Lema a cenzura literacka w NRD w latach 50. i 60. XX wieku
Authors: Rajch Marek
Published: September 2024

Stanisław Lem, jako jeden z najbardziej rozpoznawanych polskich pisarzy powojennych, cieszył się dużą popularnością i uznaniem wśród czytelników w obu państwach niemieckich. Wynikało to z niewątpliwie z wysokiej wartości artystycznej i atrakcyjności jego utworów, ale jednocześnie z faktów, że ich opublikowanie gwarantowało wydawnictwom sukces ekonomiczny. Z punktu widzenia funkcjonowania cenzury w warunkach państw totalitarnych szczególnie interesujący jest stosunek cenzury literackiej w NRD do twórczości Lema. W niniejszym opracowaniu przedstawiono procedurę udzielania zezwolenia na druk w przypadku czterech utworów: „Astronauci”, „Dzienniki gwiazdowe”, „Obłok Magellana” i „Niezwyciężony”. Analiza obejmuje lata pięćdziesiąte i sześćdziesiąte XX wieku, w których system instytucjonalnej cenzury w NRD ulegał kolejnym przeobrażeniom aż do ostatecznego ukształtowania się w 1963 roku.
Co to znaczy szukać? [Małgorzata Krakowiak, O obowiązku szukania. Wybory światopoglądowe polskich pisarzy z XX stulecia, Łomianki: Wydawnictwo LTW 2018, ss. 326]
Authors: Dębska-Kossakowska Aleksandra
Published: September 2024

Autorka podjęła próbę przedstawiania swoich bohaterów w chwilach poszukiwań, bo dla niej, „szukać” znaczy tyle co „starać się zrozumieć”. Wyjaśnia to w Słowie wstępnym: „Zrozumieć, na ile to możliwe, świat, innych ludzi oraz motywacje ich działań, zrozumieć siebie, czyli uzmysłowić sobie własny stosunek do określonej skali wartości, wyznaczyć swoje zadania. Starają się zrozumieć, jak i po co mają pisać, malować, rozmawiać….”. Chodzi więc o poszukiwanie sensu, które wymaga wysiłku myślenia, myślenia na poziomie aksjologicznym. Refleksje Krakowiak oscylują wokół skal wartości dostrzeżonych w twórczości literackiej, krytycznej, malarskiej Bolesława Leśmiana, Kazimierza Wyki, Jana Błońskiego, Marii Czapskiej, Józefa Czapskiego, Jerzego Stempowskiego, Jana Józefa Szczepańskiego, Andrzeja Stasiuka. Zaproponowana przez badaczkę konstelacja twórców znajduje doskonałe uzasadnienie w dwóch, wzajemnie przenikających się perspektywach - ideowej i kompozycyjnej. Lektura całości przypomina, że myślenie jest etycznym obowiązkiem człowieka, a nawet więcej, dowodził tego Michał Heller: „myślenie jest też ludzkim przeznaczeniem”, bo przecież „to właśnie myślenie stworzyło człowieka, a także całą jego kulturę i cywilizację”. Autorkę interesuje i człowiek, który podejmuje próbę zrozumienia, i artystyczny kształt jego poszukiwań.
Remigiusz Szauer, Between the Need for Sensations and the Persistence of Attitudes. Religiousness and Morality of High School and University Students in the Koszalin-Kołobrzeg Diocese. A Sociological Study, Publishing House: WWS, Warsaw 2019, pp. 481
Authors: Choczyński Marcin
Published: September 2024

The work of fr. Remigiusz Szauer represents another theoretical and empirical publication in the rather rich reserve of Polish studies of religion and religiosity of selected social categories. One can recall here works that have relatively recently been published (Mariański 2018; Štefanák 2018 – work on Slovak youth; Zaręba, Zarzecki 2018) and at the same time constitute a continuation of the research tradition undertaken by distinguished authors in the field of sociology of religion, e.g. Władysław Piwowarski and Janusz Mariański. Suffice to say that the entire sphere of the Polish sociology of religion in relation to this specific dimension, i.e. the study of juvenile religiosity, is characterized by a large number of both conducted studies and publications presenting the results of analyses. These are mostly studies that refer to a statistical, quantitative picture of the character of young people’s beliefs, change trends and the essence of expressed participation in a worship (Zaręba 2003; Mariański 2008; Zaręba 2008; Zaręba 2012). Comprehensive studies on the religiosity of young people also allow us to capture specific historical and generational dimensions of social life, their basic configurations.
Inżynierska koncepcja podstaw chrześcijańskich nauk społecznych
Authors: Turkiewicz Kazimierz
Published: September 2024

Powszechnie uważa się, że religie zajmują się głównie życiem duchowym, dlatego nie zwraca się uwagi na ogromną racjonalną wiedzę dotyczącą codziennego życia człowieka i społeczeństwa zawartą w ich Pismach Świętych. Praca pokazuje, że przekonanie to jest całkowicie błędne w stosunku do religii chrześcijańskiej. Analiza jej Pism Świętych przy użyciu metodologii inżynierskiej wykazała, że zawierają one kompleksowy racjonalny system humanistycznej idei społecznej. Jej podstawowym elementem, który przedstawia historia Adama i Ewy, jest stabilne funkcjonowanie społeczeństwa, gdyż każda jego dezorganizacja destabilizuje życie odpowiedniej liczby osób; im większa i silniejsza, tym bardziej niebezpieczna i tragiczna.Stabilne funkcjonowanie społeczeństwa osiąga się poprzez utrzymywanie stale istniejących sprzeczności w optymalnym zakresie, aby ułatwić ludziom niemal bezkonfliktowe życie i umożliwić rozwój społeczeństwa. Życie Jezusa Chrystusa i jego przypowieści przedstawiają ideę skutecznego sposobu kształtowania optymalnego poziomu sprzeczności, a tym samym stabilnego funkcjonowania społeczeństwa. Ta idea polega na samoograniczeniu wzrostu i wykorzystaniu dużej siły społecznej dowolnego rodzaju do rozwiązywania sprzeczności, tak aby nie dochodziło do konfliktów. To samoograniczenie powinno być realizowane poprzez odpowiednie tworzenie mechanizmów społecznych. Przykładem takiego rozwiązania jest demokracja parlamentarna, która ogranicza wzrost władzy politycznej tak, aby nie tworzyły się dyktatury.
Telewizyjne poranki w Japonii: socjologiczne aspekty asadora
Authors: Mandrewicz-Kanasugi Amelia
Published: September 2024

Za jeden z najważniejszych gatunków telewizyjnych uchodzi serial, który ze względu na dostarczanie informacji o otaczającej rzeczywistości może być uznawany za „fakt społeczny”, a jego konsumpcja staje się elementem codziennych praktyk. Odzwierciedleniem tego podejścia jest również metafora „medialnego lustra rzeczywistości”, którą opisywane są seriale telewizyjne. Podobnie myśli się o konkretnym gatunku serialu telewizyjnego w Japonii, czyli o porannych serialach znanych pod nazwą asadora. Celem artykułu jest przybliżenie historii japońskich seriali porannych, ich specyfiki, pełnionych funkcji, a także próba scharakteryzowania tego gatunku, odmiennego od opery mydlanej, sitcomu czy rodzimej telesagi. Punktem odniesienia są prace polskich badaczy seriali telewizyjnych oraz wykorzystana przez nich metodologia. Zwieńczeniem pracy jest przedstawienie serialu porannego Chiritotechin, który można uznać za wzorcowy przykład omawianego gatunku.
Focusing on Enzyme Suppression in Neurodegenerative Disorders: Promising Approaches for Therapeutic Measures
Authors: Kumar Shivendra , Saha Sunam , Singh Talever , Tripathi Ram Babu , Singh Kuldeep , Dwivedi Vivek , Singh Shubham , Chandra Deep
Published: September 2024

:

Neurodegenerative diseases, characterized by the progressive degeneration of neurons, represent a significant and growing global health concern.
Despite extensive research, the underlying molecular mechanisms driving these conditions remain elusive. Enzyme dysregulation has emerged as a
pivotal player in the pathogenesis of various neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases.
Understanding and targeting these enzymes hold immense therapeutic potential for mitigating disease progression. This abstract summarizes the
current state of knowledge regarding the involvement of enzymes in neurodegenerative diseases and explores the potential therapeutic
interventions aimed at enzyme inhibition. First, we provide an overview of the key enzymes implicated in each disorder and highlight their specific
roles in neurodegenerative processes. Next, we delve into the intricate interplay between enzyme dysregulation and disease progression,
elucidating the cascade of events leading to neuronal death and cognitive decline. Additionally, we explore promising preclinical and clinical
studies that have shown encouraging results in inhibiting specific enzymes, validating the therapeutic potential of targeting these pathways. In
conclusion, targeting enzyme inhibition in neurodegenerative diseases holds immense promise as a therapeutic avenue to slow disease progression
and improve patients' quality of life. Nevertheless, considerable challenges lie ahead, necessitating collaborative efforts among researchers,
clinicians, and pharmaceutical companies to develop safe, effective, and precise interventions for combating these devastating disorders. With
continued advancements in molecular biology and drug discovery, we remain optimistic that the targeted modulation of enzymes will pave the way
for innovative and transformative treatments in the realm of neurodegenerative diseases.
Identification of Peptidoglycan Glycosyltransferase FtsI as a Potential Drug Target against Salmonella Enteritidis and Salmonella Typhimurium Serovars Through Subtractive Genomics, Molecular Docking and Molecular Dynamics Simulation Approaches
Authors: Gulzar Imran , Khalil Asma , Ashfaq Usman Ali , Liaquat Sadia , Haque Asma
Published: September 2024

Introduction:

Salmonella enterica serovar Enteritidis and Salmonella enterica serovar Typhimurium
are among the main causative agents of nontyphoidal Salmonella infections, imposing a significant global
health burden. The emergence of antibiotic resistance in these pathogens underscores the need for innovative
therapeutic strategies.

Objective:

To identify proteins as potential drug targets against Salmonella enteritidis and Salmonella typhimurium
serovars using in silico approaches.

Methods:

In this study, a subtractive genomics approach was employed to identify potential drug targets. The
whole proteome of Salmonella enteritidis PT4 and Salmonella typhimurium (D23580), containing 393 and 478
proteins, respectively, was analyzed through subtractive genomics to identify human homologous proteins of
the pathogen and also the proteins linked to shared metabolic pathways of pathogen and its host.

Results:

Subsequent analysis revealed 19 common essential proteins shared by both strains. To ensure hostspecificity,
we identified 10 non-homologous proteins absent in humans. Among these proteins, peptidoglycan
glycosyltransferase FtsI was pivotal, participating in pathogen-specific pathways and making it a promising
drug target. Molecular docking highlighted two potential compounds, Balsamenonon A and 3,3',4',7-Tetrahydroxyflavylium,
with strong binding affinities with FtsI. A 100 ns molecular dynamics simulation having
10,000 frames substantiated the strong binding affinity and demonstrated the enduring stability of the predicted
compounds at the docked site.

Conclusion:

The findings in this study provide the foundation for drug development strategies against Salmonella
infections, which can contribute to the prospective development of natural and cost-effective drugs targeting
Salmonella Enteritidis and Salmonella Typhimurium.
The Effect of Hydroxysafflor Yellow A on Inflammatory Injury in LPS-induced Endothelial Cell Injury Model through TLR4/NF-κB Pathway Based on Network Pharmacology and Experimental Verification
Authors: Guo Qinghua , Zhu Xiaoyan , Zhang Xiaoyang , Wang Xu , Fu Feida , She Wandong
Published: September 2024

Objective:

The objective of this study is to search for hydroxysafflor yellow A
(HSYA) and Idiopathic sudden sensorineural hearing loss (ISSNHL)-related target genes and to
study the treatment effects of HSYA on lipopolysaccharide (LPS)-induced endothelial cell injury

Methods:

We used network pharmacology to screen molecules related to HSYA and ISSNHL,
then analyzed these molecules and their enriched biological processes and signaling pathways
via Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). We selected
inflammation-related hub genes for molecular docking determination by protein-protein interaction
(PPI) analysis, and further verified them with in vitro experiments.

Results:

Thirty-four HSYA-ISSNHL-related differential genes were obtained using drug-disease
differential gene screening using online tools. Three key proteins, NF-κB, CASP3, and
MAPK1, were selected according to Degree > 20. Among them, NF-κB is closely related to
inflammation and ISSNHL. In in vitro experiments, HSYA reduced inflammatory (IL-6, TNF-
α) and oxidative stress (ROS, SOD and MDA) indicators after LPS intervention, and the expression
of NF-κB-related signaling pathway genes.

Conclusion:

HSYA may reduce inflammation and oxidative stress by inhibiting the expression
of the TLR4 / NF-κB-related signaling pathway, therefore protecting endothelial cells, which
might be a potential mechanism of HSYA in ISSNHL treatment.
Effects of Long-Term Inhaled Corticosteroid Therapy on Metabolic And Anthropometric Parameters in Pediatric Patients with Asthma
Authors: Heidari Solmaz , Fathi Mohammadreza , Aminzadeh Majid , Torabizadeh Mehdi , Nasehi Najimeh , Valavi Ehsan , Mohammadi Shooka
Published: September 2024

Background:

Long-term impacts of inhaled corticosteroids (ICSs) on metabolic parameters
of asthmatic children are still uncertain.

Objective:

This study aimed to evaluate the effects of long-term use of ICSs on metabolic and anthropometric
measures among children with asthma in Iran.

Methods:

This case-control study was conducted among 200 pediatric asthmatic patients who
were referred to Abuzar Hospital (Ahvaz, Iran) during nine months. Demographic and clinical data
of the patients were recorded. The participants were categorized into two groups: Group 1 (n =
100) comprising children with moderate to severe asthma, and Group 2 (n = 100) consisting of
those with mild asthma.

Results:

The average age of 200 patients was 8.1 ± 2.9 years. The majority of them were male.
The prevalence of wasting, stunting, obesity, and overweight was higher among Group 1 compared
to Group 2 (p < 0.05). Patients in Group 1 had significantly higher levels of calcium, vitamin
D, lipids, and glycemic parameters than those in Group 2 (p < 0.05). In addition, the duration
of ICS use was notably longer in Group 1 (p < 0.05).

Conclusion:

Children with moderate and severe asthma had significantly elevated lipid and
glycemic parameters, as well as a higher prevalence of wasting, stunting, obesity, and overweight
compared to patients with mild asthma. Further studies involving larger sample sizes and longer
durations are necessary to confirm these findings.
Effect of Ginger Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis
Authors: Shoaibinobarian Nargeskhatoon , Riahi Roya , Heidari-Beni Motahar , Kelishadi Roya
Published: September 2024

Background:

Ginger (Zingiber officinale), as one of the herbal medicines, has high antioxidant
activity. It may have protective effects against hepatotoxicity. This study seeks to perform
a systematic review and meta-analysis on the impact of ginger on liver enzymes.

Methods:

The present systematic review and meta-analysis study adhered to the guidelines outlined
in the PRISMA 2020 statement. A comprehensive literature search was carried out in the
Medline database (PubMed), Google Scholar, Embase, Scopus, Web of Science, and Cochrane Library
until the conclusion of February 2021. All interventional animal studies were included. The
selected studies were the ones that examined the impact of ginger on serum liver enzymes.

Results:

Out of 741 articles, 39 studies were incorporated into the systematic review and meta-analysis.
The pooled results suggested that ginger significantly reduced alanine aminotransferase
(ALT) (standardized mean difference (SMD): 2.52, 95% confidence interval (CI): 2.12 to 2.93),
aspartate aminotransferase (AST) (SMD: 3.03, 95% CI: 2.48 to 3.58), and alkaline phosphatase
(ALP) (SMD: 2.10, 95% CI: 1.60 to 2.60).

Conclusion:

Ginger has favorable effects on liver enzymes. It shows potential as a beneficial complementary
therapy for higher levels of ALT, AST, and ALP because of its useful effects and negligible
side effects.
Validation of Renal Function using Multiphasic Ratios between Renal Cortex and Medulla in Kidney Recipients
Authors: Wang Chao , Song Yancheng , Pan Zhibin , Li Guoce , Zhang Lei , Bian Hao , Liu Fenghai , Yuan Xiaodong
Published: September 2024

Objective:

To verify the multiphase ratio of Computer Tomography-value between the renal cortex and renal medulla, which can be used to concisely
evaluate renal function in kidney recipients.

Methods:

Fifty-eight kidney recipients were retrospectively enrolled and divided into the Normal group(eGFR≥90 mL/min/1.73m2) and Abnormal
group(eGFR<90 mL/min/1.73m2) according to Chronicle Kidney Disease Epidemiology Collaboration (eGFR(CKD-EPI)) and the Modular of Diet
in Renal Disease (eGFR(MDRD)) formulas respectively. The multiphasic ratios between the renal cortex and medulla in the arterial phase and
venous phase were noted as A(RatioC/M) and V(RatioC/M), and the difference between those two was recorded as D(RatioC/M). Correlation/regression
analysis, student t-test, and ROC curves analysis were used to test the ability of multiphasic ratios to assess renal function.

Results:

Both A(RatioC/M) and V(RatioC/M) were moderately correlated with eGFR(CKD-EPI) (Y =20.41*X + 28.20, r=0.40 (95%Cl, 0.13-0.58), P<0.01; Y
=-16.57*X + 109.8, r=-0.29 (95%Cl, -0.51--0.04), P=0.03) and eGFR(MDRD) (Y =23.72*X + 23.52, r=0.38 (95%Cl, 0.13-0.58), P<0.01; Y
=-19.88*X + 119.5, r=-0.30 (95%Cl, -0.52--0.05), P=0.02). However, D(RatioC/M) was strongly positive correlated with eGFR(CKD-EPI) (Y =
30.95*X + 60.71, r=0.61 (95%Cl,0.42-0.75), P<0.001) and eGFR(MDRD) (Y = 36.47*X + 61.01, r=0.62 (95%Cl, 0.44-0.76), P<0.001),
respectively, and both regression lines were not significant different (slope: P=0.496, intercept: P=0.378). The differences in D(RatioC/M) between
the two groups were significant (all P<0.05). The ROC curve analysis provided the cutoff values of D(RatioC/M) for assessing eGFR (AUC:0.863
and AUC:0.822, all P<0.001).

Conclusion:

The D(RatioC/M) can be used to assess renal function for kidney recipients.
Unveiling the Anti-cancer Potential of Oxadiazole Derivatives: A Comprehensive Exploration of Structure-Activity Relationships and Chemico-Biological Insights
Authors: Mishra Sai Satyaprakash , Samanta Ajeya , Paul Abhik , Maji Avik , Maity Tapan Kumar
Published: September 2024

Background:

Oxadiazole derivatives have shown significant potential as anti-cancer
agents with low μM potencies. Some examples of drugs in this class include Raltegravir, Zibotentan,
Setileuton (MK-0633), Nesapidil, Furamizole, and Tidazosin. The presence of the oxadiazole
nucleus in Raltegravir exemplifies its importance in drug development, showcasing how specific
structural motifs like oxadiazole can be strategically incorporated into molecules to achieve
desired therapeutic effects. A large number of researchers across the globe have already developed
and reported many oxadiazoles as potential anti-cancer medicines.

Objective:

Therefore, we tried to discuss the anti-cancer potentials of oxadiazole derivatives reported
between 2019 and 2023. The design strategies, structure-activity relationship (SAR), and protein-
inhibitor interactions of potential compounds on different targets have to be identified to help
the medicinal chemists design new drug-likeness oxadiazole molecules for anti-cancer therapy.
Similarly, the ADMET profiles of potential oxadiazoles using the in silico SWISSADME tool have
to be studied.

Results:

We have highlighted the recently reported most potent oxadiazole derivatives as well as
their hybrid compounds. The SAR study revealed that oxadiazole-linked pyridine, indazole, thiadiazine,
quinoxaline, thiazolidine, indeno-pyrazole, thiophene, piperidine, benzimidazole, triazole,
and sulphonamide showcased promising anti-cancer action. The chemico-biological interactions of
potential oxadiazole compounds suggest good interactions with different amino acid residues that
make them possible candidates for developing novel and effective anti-cancer therapies. Similarly,
the in silico ADMET report suggested favourable physicochemical, pharmacokinetic, and druglikeness
properties of potential oxadiazole compounds.

Conclusion:

Overall, these results will prove to be a helpful and vital tool for medicinal chemists
investigating and working with oxadiazoles for anti-cancer action.
Exploring the Bioactive Constituents and Pharmacological Activity of Scutellaria baicalensis Georgi, or Chinese Skullcap
Authors: Singh Sonia , Tiwari Suryansh , Agrawal Ronak
Published: September 2024

Introduction:

Scutellaria baicalensis Georgi, a plant with therapeutic properties, has
been extensively utilized in China for centuries. The extract derived from its roots is commonly
referred to as Huang-Qin.

Materials and Methods:

The informative data were gathered from many electronic databases,
including Scopus, Science Direct, PubMed, and Web of Science. The study criteria for selection
included analyzing scientific manuscripts that specifically investigated phytoconstituents and
their pharmacological effects. The keywords used were Scutellaria baicalensis, bioactive components,
and pharmacological profile.

Discussion:

The main concern of this study is to enhance the accessibility of extensive research
discoveries about the pharmacological potential of S. baicalensis.

Results:

S. baicalensis root has been utilized to manage dysentery, diarrhea, hypertension, insomnia,
inflammation, respiratory infections, and hemorrhaging. Wogonoside and baicalin are the
primary bioactive constituents obtained from S. baicalensis root. The flavones have been documented
to possess many pharmacological properties, such as hepatoprotective, anti-cancer, antibacterial,
antioxidant, antiviral, neuroprotective, and anticonvulsant activities.

Conclusion:

This manuscript's main concern is to enhance the accessibility of extensive research
discoveries about the pharmacological potential of S. baicalensis.
A Comprehensive Review on Co-Crystals: Transforming Drug Delivery with Enhanced Solubility and Bioavailability
Authors: Sharma Sharad , Kaur Malkiet , Nagpal Manju
Published: September 2024

Poor solubility and bioavailability of various drug compounds are the biggest challenges
faced by researchers and industrialists, hindering their therapeutic efficacy. Researchers
have developed a versatile approach to enhance the solubility and bioavailability of the drug i.e.,
co-crystallization. Pharmaceutical co-crystals are solid, crystalline materials consisting of API
and co-formers that have supramolecular chemistry with one another. Co-crystallization helps in
enhancing a drug’s physico-chemical properties, such as bioavailability, solubility and dissolution,
preserving its therapeutic effect. The API and co-former in co-crystals are bound to each
other via hydrogen bonding, π-stacking, and Van der Waals forces.

Several methods to prepare co-crystals, such as solvent evaporation method, grinding method,
cooling crystallization method, etc, and various research reports, including all the methods of
preparation are discussed in this review article. Conventional marketed products and patents on
co-crystals are also included. Data has been gathered, and relevant literature reports have been
examined utilizing a variety of search engines, including Google Scholar, ScienceDirect, Pubmed,
and Google patents. After reviewing the literature, the researchers found that the cocrystallization
method is one the simplest method to enhance drug bioavailability and solubility.
Moreover, it enhances the pharmacokinetics parameters, pharmacodynamics properties, and
melting point of the drug. In this review article, the researchers have compiled the recent literature
reports on enhanced drug solubility via co-crystallization method.

The researchers concluded that this review article can help other researchers by providing them
with recent literature on this article and can compare the various methods of enhancing drug
solubility and bioavailability. It also consists of compiled data of patents and marketed formulations
prepared by the co-crystallization technique. Thus, co-crystallization could be established
as a versatile approach for enhancing drug solubility and bioavailability.
Fabrication of Ti/Zr-SnO2/PbO2-Nd Electrode for Efficient Electrocatalytic Degradation of Alizarine Yellow R
Authors: Zhang Jing , Yang Bi , Gao Guan-Jin , Miao Qing-Dong , Hu Wei-Guo , Yu Jin-Gang
Published: September 2024

Introduction:

A novel attempt to degrade alizarine yellow R (AYR) by lead dioxide
(PbO2)/ neodymium (Nd) coated Ti anode was investigated.

Method:

Ti/Zr-SnO2/PbO2-Nd electrode showed high oxygen evolution potential, high current
density, and neutral conditions, which favored the degradation of AYR. The PbO2-Nd layer on
Ti/Zr-SnO2 was further characterized by scanning electron microscopy, and X-ray diffraction
analysis, and X-ray photoelectron spectroscopy. The electrochemical properties of Ti/Zr-
SnO2/PbO2-Nd electrode were evaluated by cyclic voltammetry, AC impedance spectroscopy,
and accelerated life test.

Result:

The relatively higher oxygen evolution overpotential (~1.80 V) of the developed electrode
can effectively suppress the occurrence of surface side reactions and oxygen evolution. A
relatively lower charge transfer resistance (Rct, 18.0 Ω) of Ti/Zr-SnO2/PbO2-Nd electrode could
be found. The Ti/Zr-SnO2/PbO2-Nd electrode exhibited an accelerated lifetime of 110 min under
a very high current density of 10,000 A/m2. The doping of Nd could produce loosely-stacked
sheet-like structures, thus, the number of active sites on the electrode surface increases.

Conclusion:

Moreover, an outstanding conductivity of Ti/Zr-SnO2/PbO2-Nd electrode was obtained,
which favored the electron transfer and catalytic activity of the modified electrode. The
Ti/Zr-SnO2/PbO2-Nd electrode exhibited improved electrochemical performances and higher
oxygen evolution potential, and the highest oxygen evolution potential is 1.80 V. Under the current
density of 30 mA/cm2, the electrocatalytic degradation of 92.3% could be achieved in 180
min. The electrochemical oxidation of AYR at the Ti/Zr-SnO2/PbO2-Nd electrode proved to be
feasible and effective, indicating that it might be used for the elimination of AYR from
wastewater.

conclusion:

The electrochemical oxidation of AYR at the Ti/Zr-SnO2/PbO2-Nd electrode proved to be feasible and effective, indicating that it might be used for the elimination of AYR from wastewater.
Empowering Natural Medicine: Nanocarrier-based Oral Delivery of Vigna radiata Extract for Effective Diabetes Management
Authors: Sharma Bhawna , Kumar Gaurav , Chauhan Iti , Tiwari Raj Kumar
Published: September 2024

Background:

Poor solubility and low oral bioavailability are major challenges associated
with the oral delivery of the antidiabetic drug Vigna radiata (VR). Nanostructured lipid carriers
(NLCs) have emerged as a promising strategy to overcome these limitations and improve the therapeutic
efficacy of VR. This study investigated the potential of NLCs for VR delivery and explored
the influence of formulation parameters on NLC properties and drug release behavior.

Methods:

NLCs loaded with VR were prepared using the melt emulsion ultrafiltration technique. The
effect of two key formulation variables – the ratio of liquid lipid to solid lipid and the concentration
of the surfactant – were investigated in terms of particle size, zeta potential, and drug encapsulation
efficiency. The in vitro release profiles of the VR-NLC formulations were evaluated, and the optimal
formulation was subjected to further analysis to investigate its release kinetics.

Results:

The NLCs exhibited particle sizes ranging from 108.9 to 192.3 nm and all formulations possessed
a negative zeta potential (-3.68 to -10.9 mV), indicating good stability and potential for resisting
aggregation. Interestingly, the lowest solid lipid to liquid lipid ratio and the lowest surfactant
concentration yielded the highest drug encapsulation efficiency, highlighting the complex interplay
between these factors. All VR-NLC formulations exhibited a biphasic, time-dependent in vitro release
pattern, suggesting an initial burst release followed by a sustained release phase. This biphasic
profile is promising for achieving both rapid onset of action and long-lasting glycemic control, which
are crucial aspects of effective diabetes management.
The optimized NLC formulation showed an in vitro release pattern that adhered to the Higuchi diffusion
model, suggesting a controlled release mechanism where the drug diffuses steadily out of the
NLC matrix. This finding indicates potentially predictable and consistent drug delivery in vivo.

Conclusion:

This study demonstrates the potential of NLCs as a promising platform for the controlled
oral delivery of VR. NLCs can overcome the inherent limitations of VR and provide a convenient
and effective oral antidiabetic option for patients. Further research is needed to confirm the
efficacy and safety of NLC-encapsulated VR in vivo using relevant animal models. This will pave
the way for the development of a novel and potentially transformative treatment option for diabetes.
PENGARUH CORPORATE SOCIAL RESPONSIBILITY DISCLOSURE TERHADAP PROFITABILITAS PERUSAHAAN SEKTOR ENERGI INDONESIA SHARIA STOCK INDEX 2021-2022
Authors: Rofiq Achmad Rozaan  , - Dwi Retno Widiyanti
Published: September 2024

This article aims to determine the effect of corporate social responsibility on the profitability of energy sector companies registered with ISSI for the 2021-2022 period. This research uses a descriptive quantitative approach to find the effect of CSRD on profitability as measured using Return on Equity (ROE) with leverage and liquidity control variables by conducting a Least Square based panel data linear regression test. The results of the analysis show that CSRD has a significant positive effect on ROE, while Leverage (Debt to Equity Ratio) has no effect on ROE and liquidity (Current Ratio) has a negative effect on ROE. Keywords: Corporate Social Responsibility Disclosure, Corporate Social Responsibility, Profitability, Leverage, Liquidity.
ANALISIS PERAN DANA DESA DAN ISLAMIC HUMAN DEVELOPMENT INDEX (I-HDI) TERHADAP TINGKAT KEMISKINAN (STUDI KASUS PADA PROVINSI JAWA TIMUR PERIODE 2018 - 2022)
Authors: Hayatuzzahrah Taqiyyah  , Sri Muljaningsih
Published: September 2024

Poverty is still a major problem today in the economy. This problem is increasing with the COVID-19 pandemic. The solution to poverty alleviation is carried out by the government, namely the allocation of village funds. In addition, poverty alleviation can be seen from human resources which is a factor in poverty, namely the Islamic Human Development Index by applying aspects of Maqashid Syariah. The purpose of this study is to see how the influence of village funds and the Islamic Human Development Index on poverty alleviation in East Java Province. This research is quantitative using panel data analysis with variables of village funds, Islamic Human Development Index (X variable) and poverty rate (Y variable). The research was conducted in 29 districts in East Java in the period 2018-2022. The result of this study is the selection of fixed effect model. Furthermore, the village fund variable has a negative and significant influence on the poverty rate in East Java. The Islamic Human Development Index variable has a negative and insignificant effect on the poverty rate. This result is expected to be an effective solution for poverty alleviation through village funds in order to maximize allocation and the Islamic Human Development Index has a further impact on poverty alleviation.
Keywords: Village funds; I-HDI; Poverty; Allocation
PENGARUH PENGETAHUAN INVESTASI, PENDAPATAN DAN KEMAJUAN TEKNOLOGI TERHADAP MINAT INVESTASI MASYARAKAT USIA PRODUKTIF DI REKSA DANA SYARIAH MELALUI APLIKASI BIBIT
Authors: Al Farizi Muhammad Hafidz , Ajeng Kartika Galuh
Published: September 2024

Investment is one of the crucial matters in people’s personal financial management. Therefore, younger generations have started to make investments in capital markets. Indonesia has the largest potential of becoming the largest capital market globally. Unfortunately, Islamic capital market in the country, especially Islamic mutual funds, is still far behind the conventional ones. Therefore, in order to ensure that the huge potential is not wasted, effective measures to increase people’s intention for investment in Islamic capital market, especially in Islamic mutual funds, are required. The objective of this research is to investigate the effects of investment knowledge, income, and technological advancement on the intention of productive-age people to invest in Islamic capital market, particularly Islamic mutual funds, through Bibit. Using random sampling, 100 people were selected as the respondents. The results of the data analysis using multiple linear regression indicate that investment knowledge, income, and technological advancement influence the intention of productive-age people to invest in Islamic mutual funds through Bibit.
ANALISIS FAKTOR PENGARUH KEPUTUSAN ASN DALAM MENGELUARKAN ZAKAT PROFESI MELALUI BAZNAS
Authors: Al Jihad Hizbullah , Ekawaty Marlina
Published: September 2024

According to the BAZNAS Strategic Studies Center, the potential for zakat in Indonesia in 2020 reaches Rp. 327.6 trillion, but the amount of zakat collected in the same year was only around Rp. 12.429 trillion. In this study, Maros Regency was chosen as the research focus because BAZNAS Maros Regency received a total income of Rp. 6,184,383,403 in 2022, with the largest contribution coming from zakat fitrah of Rp. 1,646,818,000, followed by zakat maal (from entities/organizations) of 315,092,717, which came from professional zakat paid by ASN Maros Regency. The purpose of this research is to identify the factors that influence the decisions of ASNs in Maros Regency in issuing professional zakat through BAZNAS in Maros Regency. This study uses a quantitative approach with binary logistic analysis method. The population consists of ASNs in Maros Regency groups 3 and 4 who are Muslim with a sample of 100 respondents. The results showed that the variable knowledge of zakat and service quality had a significant influence on the decisions of ASNs in Maros Regency in issuing professional zakat through BAZNAS in Maros Regency. Meanwhile, the variables of income and trust have no significant effect on the decisions of ASNs in Maros Regency in issuing professional zakat through BAZNAS in Maros Regency. This research is expected to be the basis for BAZNAS in Maros Regency in optimizing the potential for professional zakat among ASNs in Maros.
ANALISIS PENGARUH VARIABEL MAKROEKONOMI TERHADAP PENERBITAN SUKUK KORPORASI DI INDONESIA
Authors: Monica Siti Nurlaila  , Atu Bagus Wiguna
Published: September 2024

Islamic finance in Indonesia in recent years has continued to increase, and the issuance of Sukuk dominates the growth of Islamic finance. However, when viewed from the distribution of corporate Sukuk, growth is lower than state Sukuk. One of the causes of the joint development of corporate Sukuk is the changing macroeconomic factors in Indonesia. Therefore, this study aims to analyze the effect of macroeconomic variables, namely inflation (consumer price index); GDP (gross domestic product); JUB (money supply); and exchange rate (exchange rate) on corporate Sukuk in Indonesia from 2015.7-2020.12. This study uses the Error Correction Model analysis method using Eviews-10 software. This study processes data monthly in the order of July 2015 to October 2020. The results of this study indicate that inflation has a negative and significant effect on the issuance of corporate Sukuk. Gross Domestic Product (GDP) and Total Money Supply (JUB), in a broad sense (M2), have a positive and significant effect. Meanwhile, the exchange rate in this study does not affect the issuance of corporate Sukuk in Indonesia.
PENGARUH KESADARAN HALAL, GAYA HIDUP, DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN SHOPEE FOOD
Authors: Fuadah Aulia Tsamrotul , Ghozali Maski
Published: September 2024

The dominating Muslim population in Indonesia and the increase in the number of products that have been halal certified have not been able to describe the consumption behavior of Muslims to be more selective in ensuring the halalness of a product. The purpose of this study is to research and analyze the influence of halal awareness, lifestyle, and product quality on Muslim consumers' decisions on the food delivery service application Shopee Food. The samples obtained were 120 respondents. The analytical tests used are data instrument quality tests, coefficient of determination (R2), classic assumption test, principal component regression analysis with a confirmatory factor analysis approach, t test, and F test. The results of the analysis state partially and simultaneously the variables of halal awareness, lifestyle , and product quality has a significant positive effect on purchasing decisions in the Shopee Food application.
PENGARUH PEMBIAYAAN SYARIAH, PEMASARAN, DAN LITERASI KEUANGAN TERHADAP OMZET USAHA MIKRO KECIL DAN MENENGAH (UMKM) PADA SAAT PANDEMI COVID-19
Authors: Afif Abdurrasyid Ahmad  , Bahtiar Fitanto
Published: September 2024

This study examines the impact of Sharia Financing, Marketing, and Financial Literacy on the revenue of Micro, Small, and Medium Enterprises (MSMEs) in Kota Malang. The findings indicate that these three variables have a positive simultaneous influence on MSME revenue. Sharia Financing were identified as the variable with the most significant effect, suggesting that improved access to capital can enhance MSME income. Furthermore, marketing expenses contribute to revenue growth by attracting attention and building consumer loyalty. Lastly, a high level of financial literacy plays a role in effective financial management and mature business planning. This research provides insights that sharia financing, marketing, and financial literacy are key factors that can support the growth and competitiveness of MSMEs in Malang City.