bluuebunny/crossref_metadata_2025 huggingface dataset:
Formulation and evaluation of chitosan microspheres of aceclofenac for colon‐targeted drug delivery
Authors: Umadevi S. K. , Thiruganesh R. , Suresh S. , Reddy K. Bhaskar
Published: September 2010

The objective of this investigation was to develop novel colon specific drug delivery. Aceclofenac, a NSAID, was successfully encapsulated into chitosan microspheres. Various formulations were prepared by varying the ratio of chitosan, span‐85 and stirring speed and the amount of glutaraldehyde. The SEM study showed that microspheres have smooth surfaces. Microspheres were characterised by Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) to confirm the absence of chemical interactions between drug and polymer and to know the formation of microspheres structure. The microspheres were evaluated for particle size, encapsulation efficiency, drug loading capacity, mucoadhesion studies, stability studies,in vitroandin vivodrug release studies. Particle sizes, as measured by the laser light scattering technique, were of an average size in the range 41–80 µm. The swelling index was in the range 0.37–0.82 and the entrapment efficiency range was 51–75% for all the formulations. The optimised batch ACM13released 83.6% at 8 h and 104% at 24 h in SCF containing rat caecal content. Eudragit coated chitosan microspheres prevented the release of the aceclofenac in the physiological environment of the stomach and small intestine and released 95.9±0.34% in the colon. With regard to release kinetics, the data were best fitted with the Higuchi model and showed zero order release with non‐Fickian diffusion mechanism. Thein vivofindings suggest that aceclofenac microspheres exhibit a prolonged effect of aceclofenac in rats and produce a significant anti‐inflammatory effect. The findings of the present study conclusively state that chitosan microspheres are promising for colon targeting of aceclofenac to synchronise with chronobiological symptoms of rheumatoid arthritis. Copyright © 2010 John Wiley & Sons, Ltd.
Altered electrolyte handling of the choroid plexus in rats with glycerol‐induced acute renal failure
Authors: Ishikawa Atsuko , Kono Kentaro , Sakae Rie , Aiba Tetsuya , Kawasaki Hiromu , Kurosaki Yuji
Published: September 2010

The altered electrolyte handling of the choroid plexus was investigated in rats with acute renal failure (ARF) using lithium and rubidium as surrogate markers for sodium and potassium, respectively. Firstly, the transport of these two markers from the plasma to cerebrospinal fluid (CSF) was evaluated after they were concurrently injected into the femoral vein. As a result, their disposition from the plasma to CSF was shown to decrease in ARF rats, but the relationship profile between those two markers was not different from that observed in normal rats, indicating that the decreased disposition of lithium and rubidium occurs without affecting the stoichiometric balance. To clarify the mechanisms accounting for the decreased disposition, an inhibition study was then performed. When bumetanide, an inhibitor of the Na+/K+/2Cl−co‐transporter, was directly introduced into the cerebroventricle prior to lithium and rubidium being intravenously administered, a marked increase in the markers' disposition was observed. However, such an increased disposition did not occur when bumetanide was injected into the femoral vein. Other inhibitors, such as amiloride for the Na+/H+exchanger and ouabain for Na+/K+‐ATPase, did not show any effects on marker disposition regardless of the inhibitor being administered into either the cerebroventricle or femoral vein. These findings suggest that the decreased marker disposition in ARF rats is due to an increased efflux process of the choroid plexus mediated by the Na+/K+/2Cl−co‐transporter. That is, electrolyte efflux from the CSF to plasma increases, and thereby the electrolyte influx from the plasma to CSF is counteracted. Copyright © 2010 John Wiley & Sons, Ltd.
Zebrafish: A tool for chemical screens
Authors: Tsang Michael
Published: September 2010

The zebrafish has proven to be an invaluable vertebrate animal model for developmental biology. Recent technological advances have added an arsenal of tools to expand its use into the realm of drug discovery. This includes methodology to generate transgenic reporter lines that allow for the direct visualization of fluorescent markers in live embryos. With the addition of automated imaging and analysis of embryos treated with small molecules, these innovations have expanded its utility into high throughput chemical screens. This review will highlight some of these advances that have propelled zebrafish as a tool for drug discovery. Birth Defects Research (Part C) 90:185–192, 2010. © 2010 Wiley‐Liss, Inc.
Mechanobiology of embryonic skeletal development: Insights from animal models
Authors: Nowlan Niamh C. , Sharpe James , Roddy Karen A. , Prendergast Patrick J. , Murphy Paula
Published: September 2010

A range of clinical conditions in which fetal movement is reduced or prevented can have a severe effect on skeletal development. Animal models have been instrumental to our understanding of the interplay between mechanical forces and skeletal development, particularly the mouse and the chick model systems. In the chick, the most commonly used means of altering the mechanical environment is by pharmaceutical agents which induce paralysis, whereas genetically modified mice with nonfunctional or absent skeletal muscle offer a valuable tool for examining the interplay between muscle forces and skeletogenesis in mammals. This article reviews the body of research on animal models of bone or joint formation in vivo in the presence of an altered or abnormal mechanical environment. In both immobilized chicks and “muscleless limb” mice, a range of effects are seen, such as shorter rudiments with less bone formation, changes in rudiment and joint shape, and abnormal joint cavitation. However, although all bones and synovial joints are affected in immobilized chicks, some rudiments and joints are unaffected in muscleless mice. We propose that extrinsic mechanical forces from movements of the mother or littermates impact on skeletogenesis in mammals, whereas the chick embryo is reliant on intrinsic movement for mechanical stimulation. The insights gained from animal models into the mechanobiology of embryonic skeletal development could provide valuable cues to prospective tissue engineers of cartilage and bone and contribute to new or improved treatments to minimize the impact on skeletal development of reduced movement in utero. Birth Defects Research (Part C) 90:203–213, 2010. © 2010 Wiley‐Liss, Inc.
Therapeutic potential of activators and inhibitors of sirtuins
Authors: Balcerczyk Aneta , Pirola Luciano
Published: September 2010

Sirtuins are evolutionary conserved NAD+‐dependent acetyl‐lysine deacetylases and ADP ribosyltransferases dual‐function enzymes involved in the regulation of metabolism and lifespan. Sirtuins are also implicated in determining the balance between apoptosis, cell survival, and cell proliferation. In humans, seven sirtuins isoforms (SIRT1–7) have been identified that localize either in the nucleus, cytoplasm, or mitochondria. The genetic demonstration that increasing gene dosage of sirtuin orthologs in eukaryotes, including yeast and multicellular Caenorhabditis elegans and Drosophila melanogaster, leads to prolonged lifespan induced considerable interest toward the discovery of sirtuin‐activating molecules, on the ground that the phenomenon of sirtuin‐induced lifespan prolongation—which is consequential to improved metabolic control—can be exploited therapeutically to counteract insulin resistance and diabetes. Conversely, ample evidence that either pharmacological inhibition or activation of sirtuin isoforms is potentially beneficial in study models of cancer and neurodegenerative diseases have been obtained. Here, we (i) survey the key roles of sirtuin isoforms and discuss the evidence in favor of activatory versus inhibitory targeting of sirtuins, (ii) discuss some of the inhibitors and activators of the sirtuin family members that have been described in the literature, (iii) review model systems in which these molecules have proved to exert therapeutic effects, and (iv) discuss the outcome of pharmacokinetic studies and phase I and II clinical trials employing sirtuin modulators. © 2010 International Union of Biochemistry and Molecular Biology, Inc.
Neuroprotective properties of resveratrol in different neurodegenerative disorders
Authors: Albani Diego , Polito Letizia , Signorini Alessandra , Forloni Gianluigi
Published: September 2010

The natural phytocompound resveratrol has been considered for many years a potential anticancer drug, but recently it has come to the attention of neuroscientist too, as it displays neuroprotective actions and activates the sirtuins' family member SIRT1. Sirtuins are enzymes with preferential deacetylase activity. Human sirtuins are coded by seven genes (SIRT1‐7). The most investigated sirtuin is SIRT1, which is involved in several physiologic and pathologic processes including apoptosis, autophagy, diabetes, cancer, cardiovascular disorders, and neurodegeneration. Resveratrol has neuroprotective features both in vitro and in vivo in models of Alzheimer's disease (AD), but it has proved to be beneficial also in ischemic stroke, Parkinson's disease, Huntington's disease, and epilepsy. Here, we summarize the in vitro and in vivo experimental results highlighting the possible role of resveratrol as neuroprotective biofactor with a particular focus on AD.
Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells
Authors: Bhui Kulpreet , Tyagi Shilpa , Prakash Bharti , Shukla Yogeshwer
Published: September 2010

Bromelain, from pineapple, possesses potent anticancer effects. We investigated autophagic phenomenon in mammary carcinoma cells (estrogen receptor positive and negative) under bromelain treatment and also illustrated the relationship between autophagy and apoptosis in MCF‐7 cells. MCF‐7 cells exposed to bromelain showed delayed growth inhibitory response and induction of autophagy, identified by monodansylcadaverine localization. It was succeeded by apoptotic cell death, evident by sub‐G1 cell fraction and apoptotic features like chromatin condensation and nuclear cleavage. 3‐Methyladenine (MA, autophagy inhibitor) pretreatment reduced the bromelain‐induced autophagic level, also leading to decline in apoptotic population, indicating that here autophagy facilitates apoptosis. However, addition of caspase‐9 inhibitor Z‐LEHD‐FMK augmented the autophagy levels, inhibited morphological apoptosis but did not prevent cell death. Next, we found that bromelain downregulated the phosphorylation of extracellular signal‐regulated kinase ½ (ERK½), whereas that of c‐jun N‐terminal kinase (JNK) and p38 kinase were upregulated. Also, MA had no influence on bromelain‐suppressed ERK½ activation, yet, it downregulated JNK and p38 activation. Also, addition of mitogen‐activated protein kinase (MAPK) inhibitors enhanced the autophagic ratios, which suggested the role of MAP kinases in bromelain‐induced autophagy. All three MAPKs were seen to be constantly activated over the time. Bromelain was seen to induce the expressions of autophagy‐related proteins, light chain 3 protein B II (LC3BII), and beclin‐1. Using ERK½ inhibitor, expressions of LC3BII and beclin‐1 increased, whereas p38 and JNK inhibitors decreased this protein expression, indicating that bromelain‐induced autophagy was positively regulated by p38 and JNK but negatively regulated by ERK½. Autophagy‐inducing property of bromelain can be further exploited in breast cancer therapy.
Bioactive Triterpenoids from Kadsura heteroclita
Authors: Xu Li‐Jia , Peng Zong‐Gen , Chen Hong‐Shan , Wang Jie , Xiao Pei‐Gen
Published: September 2010

A phytochemical study of Kadsura heteroclita led to the isolation of eight triterpenoids, including two new compounds, named kadheterilactone A (1) and kadheterilactone B (2), as well as six known compounds, longipedlactone H (3), longipedlactone A (4), longipedlactone F (5), kadsuranic acid A (6), nigranoic acid (7), and schisandronic acid (8). Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. The cytotoxic activities of 1–8 were tested against several tumor cell lines by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium hydrobromide (MTT) assay in vitro. As a result, 4 and 5 turned out to be significantly cytotoxic against Hep‐G2 and Bel‐7402 tumor cell lines. All compounds were also tested for inhibition on HIV‐1 protease (PR) and reverse transcriptase (RT). Compounds 6 and 7 showed strong inhibition on HIV‐1 PR, while 8 exhibited moderate activity, others were only weakly active. No compounds were active against HIV‐1 RT.
Regulation of the 5‐HT3A Receptor‐Mediated Current by Alkyl 4‐Hydroxybenzoates Isolated from the Seeds ofNelumbo nucifera
Authors: Joung Youn Ui , Lee Jun‐Ho , Lee Yoo Jin , Nam Joo Won , Bae Hyunsu , Seo Eun‐Kyoung
Published: September 2010

Four known alkyl 4‐hydroxybenzoates,i.e., methyl 4‐hydroxybenzoate (1), ethyl 4‐hydroxybenzoate (2), propyl 4‐hydroxybenzoate (3), and butyl 4‐hydroxybenzoate (4), were isolated from the seeds ofNelumbo nuciferaGaertner(Nymphaeaceae) for the first time. The structures of the isolates were identified by 1D‐ and 2D‐NMR spectroscopy and comparison with published values. The compounds were evaluated for their effects on the 5‐HT‐stimulated inward current (I5‐HT) mediated by the human 5‐HT3A receptors expressed inXenopusoocytes. Compounds1and2enhanced theI5‐HT, but4reduced it. These results indicate that4is an inhibitor of the 5‐HT3A receptors expressed inXenopusoocytes.
An Alternative Standard forTrolox‐Equivalent Antioxidant‐Capacity Estimation Based on Thiol Antioxidants. Comparative 2,2′‐Azinobis[3‐ethylbenzothiazoline‐6‐sulfonic Acid] Decolorization and Rotational Viscometry Study Regarding Hyaluronan Degradation
Authors: Hrabárová Eva , Valachová Katarína , Rapta Peter , Šoltés Ladislav
Published: September 2010

Comparison of the effectiveness of antioxidant activity of three thiol compounds,D‐penicillamine, reducedL‐glutathione, and 1,4‐dithioerythritol, expressed as a radical‐scavenging capacity based on the two independent methods, namely a decolorization 2,2′‐azinobis[3‐ethylbenzothiazoline‐6‐sulfonic acid] assay and a rotational viscometry, is reported. Particular concern was focused on the testing of potential free‐radical scavenging effects of thiols against hyaluronan degradation, induced by hydroxyl radicals. A promising, solvent‐independent, antioxidative function of 1,4‐dithioerythritol, comparable to that of a standard compound,Trolox®, was confirmed by the 2,2′‐azinobis[3‐ethylbenzothiazoline‐6‐sulfonic acid] assay. The new potential antioxidant 1,4‐dithioerythritol exhibited very good solubility in a variety of solvents (e.g., H2O, EtOH, and DMSO) and could be widely accepted and used as an effective antioxidant standard instead of a routinely usedTrolox®on 2,2′‐azinobis[3‐ethylbenzothiazoline‐6‐sulfonic acid] assay.
Volatile Composition Screening of Salix spp. Nectar Honey: Benzenecarboxylic Acids, Norisoprenoids, Terpenes, and Others
Authors: Jerković Igor , Marijanović Zvonimir
Published: September 2010

Salix spp. nectar honey volatiles of Croatian origin were analyzed by headspace solid‐phase microextraction (HS‐SPME) and ultrasonic solvent extraction (USE), followed by gas chromatography and mass spectrometry (GC, GC/MS). Isolated volatiles were found in the honey headspace and extracts with almost exclusive distribution of several abundant compounds (e.g., phenylacetic acid, pinocembrin, 8‐hydroxy‐4,7‐dimethylcoumarin, and 3‐hydroxy‐trans‐β‐damascone in the extracts, or safranal and lilac alcohols in the headspace). Comparison with Croatian Salix spp. honeydew honey revealed similarities regarding distribution of important shikimate pathway derivatives (e.g., high percentage of phenylacetic acid) and several norisoprenoids (α‐isophorone and 4‐oxoisophorone). On the other hand, distinct features of this honey were occurrence of compounds such as pinocembrin, 8‐hydroxy‐4,7‐dimethylcoumarin, phenylacetonitrile, norisoprenoids (major ones: 3‐hydroxy‐trans‐β‐damascenone and trans‐β‐damascone), more pronounced variability of linalool‐derived compounds, as well as the abundance of 3‐methylpropanoic acid, 3‐methylbutanoic acid, 2‐methylpentanoic acid, and 3‐methylpentan‐1‐ol.
A Survey of Phytotoxic Microbial and Plant Metabolites as Potential Natural Products for Pest Management
Authors: Schrader Kevin K. , Andolfi Anna , Cantrell Charles L. , Cimmino Alessio , Duke Stephen O. , Osbrink Weste , Wedge David E. , Evidente Antonio
Published: September 2010

Phytotoxic microbial metabolites produced by certain phytopathogenic fungi and bacteria, and a group of phytotoxic plant metabolites including Amaryllidacea alkaloids and some derivatives of these compounds were evaluated for algicide, bactericide, insecticide, fungicide, and herbicide activities in order to discover natural compounds for potential use in the management and control of several important agricultural and household structural pests. Among the various compounds evaluated: i) ophiobolin A was found to be the most promising for potential use as a selective algicide; ii) ungeremine was discovered to be bactericidal against certain species of fish pathogenic bacteria; iii) cycasin caused significant mortality in termites; iv) cavoxin, ophiobolin A, and sphaeropsidin A were most active towards species of plant pathogenic fungi; and v) lycorine and some of its analogues (1‐O‐acetyllycorine and lycorine chlorohydrate) were highly phytotoxic in the herbicide bioassay. Our results further demonstrated that plants and microbes can provide a diverse and natural source of compounds with potential use as pesticides.
Anti‐Tumor‐Initiating Effects of Spiro‐biflavonoids from Abies sachalinensis
Authors: Wada Shun‐ichi , Hitomi Teppei , Tokuda Harukuni , Tanaka Reiko
Published: September 2010

Cancer chemoprevention, the prevention of cancer by ingestion of chemical agents that reduce the risk of carcinogenesis, is one of the potent ways to reduce morbidity and mortality. We have been searching for cancer chemopreventive agents from the leaves and barks of coniferous trees that have been treated as waste in the forestry industry. We have previously reported the isolation of spiro‐biflavonoids, named as abiesinols, and a neolignan from the MeOH extract of the bark of Abies sachalinensis. These compounds were tested for their inhibitory effects on the activation of (±)‐(E)‐methyl‐2‐[(E)‐hydroxyimino]‐5‐nitro‐6‐methoxyhex‐3‐enamide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for anti‐tumor initiators. All compounds tested exhibited potent inhibitory effects on NOR 1 activation. Furthermore, abiesinol A, bearing a spiro‐biflavonoid skeleton, showed remarkable anti‐tumor‐initiating activity in the in vivo two‐stage mouse skin carcinogenesis test using peroxynitrite (ONOO−; PN) as the initiator and 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) as the promoter.
The Biosynthesis of Branched Dialkylpyrazines in Myxobacteria
Authors: Nawrath Thorben , Dickschat Jeroen S. , Kunze Brigitte , Schulz Stefan
Published: September 2010

The biosynthesis of the volatiles 2,5‐ and 2,6‐diisopropylpyrazine (2 and 3, resp.) released by the myxobacteria Nannocystis exedens subsp. cinnabarina (Na c29) and Chondromyces crocatus (strains Cm c2 and Cm c5) was studied. Isotopically labeled precursors and proposed pathway intermediates were fed to agar plate cultures of the myxobacteria. Subsequently, the volatiles were collected by use of a closed loop stripping apparatus (CLSA), and incorporation into the pyrazines was followed by GC/MS analysis. [2H8]Valine was smoothly incorporated into both pyrazines clearly establishing their origin from the amino acid pool. The cyclic dipeptide valine anhydride (16) – a potential intermediate on the biosynthetic pathway to branched dialkylpyrazines – was synthesized containing 2H1 labels in specific positions. Feeding of [2H16]‐16 and [2H12]‐16 in both valine subunits mainly resulted in the formation of pyrazines derived from only one labeled amino acid, whereas only traces of the expected pyrazines with two labeled subunits were found. To investigate the origin of nitrogen in the pyrazines, a feeding experiment with [15N]valine was performed, resulting in the incorporation of the 15N label. The results contradict a biosynthetic pathway via cyclic dipeptides, but rather point to a pathway on which valine is reduced to valine aldehyde. Its dimerization to 2,5‐diisopropyldihydropyrazine 36 and subsequent oxidation results in 2. The proposed biosynthetic pathway neatly fits the results of earlier labeling studies and also explains the formation of the regioisomer 2,6‐diisopropylpyrazine 3 by isomerization during the first condensation step of two molecules valine aldehyde. A general biosynthetic pathway to different classes of pyrazines is presented.
2‐Azapurine Nucleosides: Synthesis, Properties, and Base Pairing of Oligonucleotides
Authors: Budow Simone , Seela Frank
Published: September 2010

This review deals with 2‐azapurine (imidazo[4,5‐d] [1,2,3]triazine) nucleosides and closely related analogs. Different routes are described to yield the desired target compounds, including a sequence of ring‐opening and ring‐closure reactions performed on purine nucleosides or direct glycosylation of a 2‐azapurine nucleobase with a sugar halide. Further, physical and spectroscopic properties of 2‐azapurine nucleosides are discussed, including fluorescence, 13C‐NMR data, single‐crystal X‐ray analyses, and conformation studies on selected compounds; new biological data are presented. The second part of this review is dedicated to oligonucleotides containing 2‐azapurines, including building‐block (phosphoramidite) preparation and their use in solid‐phase oligonucleotide synthesis. Base‐pairing properties of 2‐azapurine nucleosides as surrogates of canonical constituents of DNA were evaluated.
Volatile Methyl Esters of Medium Chain Length from the Bacterium Chitinophaga Fx7914
Authors: Nawrath Thorben , Gerth Klaus , Müller Rolf , Schulz Stefan
Published: September 2010

The analysis of the volatiles released by the novel bacterial isolate Chitinophaga Fx7914 revealed the presence of ca. 200 compounds including different methyl esters. These esters comprise monomethyl‐ and dimethyl‐branched, saturated, and unsaturated fatty acid methyl esters that have not been described as bacterial volatiles before. More than 30 esters of medium C‐chain length were identified, which belong to five main classes, methyl (S)‐2‐methylalkanoates (class A), methyl (S)‐2,(ω−1)‐dimethylalkanoates (class B), methyl 2,(ω−2)‐dimethylalkanoates (class C), methyl (E)‐2‐methylalk‐2‐enoates (class D), and methyl (E)‐2,(ω−1)‐dimethylalk‐2‐enoates (class E). The structures of the compounds were verified by GC/MS analysis and synthesis of the target compounds as methyl (S)‐2‐methyloctanoate (28), methyl (S)‐2,7‐dimethyloctanoate ((S)‐43), methyl 2,6‐dimethyloctanoate (49), methyl (E)‐2‐methylnon‐2‐enoate (20a), and methyl (E)‐2,7‐dimethyloct‐2‐enoate (41a). Furthermore, the natural saturated 2‐methyl‐branched methyl esters showed (S)‐configuration as confirmed by GC/MS experiments using chiral phases. Additionally, the biosynthetic pathway leading to the methyl esters was investigated by feeding experiments with labeled precursors. The Me group at C(2) is introduced by propanoate incorporation, while the methyl ester is formed from the respective carboxylic acid by a methyltransferase using S‐adenosylmethionine (SAM).
The case for a contemplative philosophy of education
Authors: Repetti Rick
Published: September 2010

This chapter introduces contemplative practices, studies, and pedagogy and argues in support of a contemplative pedagogy.
The classroom is aSangha: Contemplative education in the community college
Authors: Haight Robert
Published: September 2010

Contemplative education, including meditation, mindfulness,lectio divina, and freewriting, regularly practiced in a classroom where a climate ofahimsaand nonjudgment are defining attitudes, can restore wholeness and foster engagement, imagination, and compassion in both instructors and students.
Being allowing and yet directive: Mindfulness meditation in the teaching of developmental reading and writing
Authors: Garretson Kate
Published: September 2010

Because learning to meditate shares important qualities with learning to be a better reader and writer—for example, dispassionate noticing, becoming more aware of inner processes, a faith in inner wisdom, effort made with a light touch, the cultivation of a practice through simple, regular doing—practice in mindfulness meditation was used to help incoming community college ESL students become more reflective in their writing and more deliberate in their reading practices.
The sound of starting where you are: Contemplative practice and music pedagogy
Authors: Shippee Matthew Ruby
Published: September 2010

This chapter describes the use of contemplative practice and curriculum design in teaching and learning music.
Offering reflection to an organization
Authors: Faulkner Ann , Gooding Guy
Published: September 2010

This chapter offers a faculty development model based on contemplative practice within a multiple‐campus community college system.
Vocatio: The importance of exploring an ancient concept for community college students
Authors: Scott Clifford “Kip”
Published: September 2010

This chapter describes the role of vocation in career exploration and first‐year orientation courses.
Contemplative practice in the classroom
Authors: Kroll Keith
Published: September 2010

This chapter offers a brief overview of the contemplative practices discussed in the volume.
A Selective Ru‐Catalyzed Semireduction of Alkynes to Z Olefins under Transfer‐Hydrogenation Conditions
Authors: Belger Christian , Neisius N. Matthias , Plietker Bernd
Published: September 2010

By using a readily available, air‐ and moisture‐stable dihydrido–Ru complex, a variety of Z olefins are accessible under transfer‐hydrogenation conditions with formic acid as the hydrogen source in excellent yields and Z/E selectivities.
An Adamantyl Amino Acid Containing Gramicidin S Analogue with Broad Spectrum Antibacterial Activity and Reduced Hemolytic Activity
Authors: Kapoerchan Varsha V. , Knijnenburg Annemiek D. , Niamat Miquel , Spalburg Emile , de Neeling Albert J. , Nibbering Peter H. , Mars‐Groenendijk Roos H. , Noort Daan , Otero José M. , Llamas‐Saiz Antonio L. , van Raaij Mark J. , van der Marel Gijs A. , Overkleeft Herman S. , Overhand Mark
Published: September 2010

The cyclic cationic antimicrobial peptide gramicidin S (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis). Herein, we present a series of amphiphilic derivatives of GS with either two or four positive charges and characteristics ranging between very polar and very hydrophobic. Screening of this series of peptide derivatives identified a compound that combines effective antibacterial activity with virtually no toxicity within the same concentration range. This peptide acts against both Gram‐negative and Gram‐positive bacteria, including several MRSA strains, and represents an interesting lead for the development of a broadly applicable antibiotic.
ChemInform Abstract: B‐19: An Aromatic Wankel Motor
Authors: Jimenez‐Halla J. Oscar C. Jimenez‐Halla J. Oscar C. , Islas Rafael , Heine Thomas , Merino Gabriel
Published: September 2010

Born—Oppenheimer molecular dynamics simulation
ChemInform Abstract: Crystal Structure and Physical Properties of Yb‐Based Intermetallics Yb(Cu, Ag)2(Si, Ge)2, Yb(Cu1‐xZnx)2Si2 (x = 0.65, 0.77) and Yb(Ag0.18Si0.82)2.
Authors: Grytsiv A. , Kaczorowski D. , Tran V.‐H. , Leithe‐Jasper A. , Rogl P.
Published: September 2010

The title compounds are characterized by powder XRD, electrical resistivity, and magnetic susceptibility measurements.
ChemInform Abstract: K2ScSn(AsO4)3: An Arsenate‐Containing Langbeinite.
Authors: Harrison William T. A.
Published: September 2010

Single crystals of the title compound are obtained from a mixture of Sc2O3, SnO2, NH4AsO4, and K2CO3 (1:1:3:1, 1173 K).
ChemInform Abstract: Oxide Ion Conductivity, Phase Transitions, and Phase Separation in Fluorite‐Based Bi38‐xMo7+xO78+1.5x.
Authors: Kuang Xiaojun , Li Yuandi , Ling Chris D. , Withers Ray L. , Evans Ivana Radosavljevic
Published: September 2010

Bi38Mo7O78 (I) and Bi37.5Mo7.5O78.75 (II) are characterized by variable‐temperature synchrotron, neutron, and laboratory powder XRD, impedance spectroscopy, TEM, and second harmonic generation measurements.
ChemInform Abstract: Crystal Structure of a New Polymorph of Li2FeSiO4.
Authors: Sirisopanaporn Chutchamon , Boulineau Adrien , Hazel Darko , Dominko Robert , Budic Bojan , Armstrong A. Robert , Bruce Peter G. , Masquelier Christian
Published: September 2010

A new polymorph of the title compound is synthesized by solid state reaction of Li2SiO3, Fe1‐xO, and Fe (900 °C, 7 d followed by quenching to 25 °C).
ChemInform Abstract: Synthesis, Crystal and Electronic Structures of New Narrow‐Band‐Gap Semiconducting Antimonide Oxides Ln3SbO3 and Ln8Sb3‐δO8 with Ln: La, Sm, Gd, and Ho.
Authors: Wang Peng , Forbes Scott , Kolodiazhnyi Taras , Kosuda Kosuke , Mozharivskyj Yurij
Published: September 2010

The title compounds are prepared from mixtures of LnSb (Ln: La, Sm, Gd, Ho) and Ln2O3 in a 1:1 molar ratio for Ln3SbO3, and LnSb, Ln2O3, and Sb in a 8:8:1 ratio for Ln8Sb3O8 (Ta tubes, 1300—1600 °C, 2—6 h).
ChemInform Abstract: Synthesis, Structure and Magnetic Properties of V4O9 — A Missing Link in Binary Vanadium Oxides.
Authors: Yamazaki Satoshi , Li Chang , Ohoyama Kenji , Nishi Masakazu , Ichihara Masaki , Ueda Hiroaki , Ueda Yutaka
Published: September 2010

Single phase V4O9 is prepared by reduction of V2O5 with sulfur using 92—94% of the stoichiometrically required sulfur amount (≈0.23 equiv.
ChemInform Abstract: Asymmetric Intermolecular N—H Insertion Reaction of Phenyldiazoacetates with Anilines Catalyzed by Achiral Dirhodium(II) Carboxylates and Cinchona Alkaloids.
Authors: Saito Hiroaki , Uchiyama Taketo , Miyake Muneharu , Anada Masahiro , Hashimoto Shunichi , Takabatake Tohru , Miyairi Shinichi
Published: September 2010

A novel catalytic system consisting of a rhodium salt and dihydrocinchonine is used for the synthesis of phenylglycine derivatives (III) by asymmetric N‐H insertion reaction of phenyldiazoacetate (I) with anilines (II).
ChemInform Abstract: Intramolecular Diels—Alder Cyclization of Biodihydroxylated Benzoic Acid Derivatives Towards Novel Heterocyclic Scaffolds.
Authors: Fischer Thomas C. M. , Leisch Hannes G. , Mihovilovic Marko D.
Published: September 2010

The potential of bio‐dihydroxylated benzoic acid (II) as a versatile precursor for the construction of novel polycyclic scaffolds utilizing intramolecular Diels—Alder cyclization reaction is demonstrated.
ChemInform Abstract: Benzylic and Allylic Oxidations with Bis(trifluoroacetoxyiodo)benzene and tert‐Butyl Hydroperoxide.
Authors: Catir Mustafa , Kilic Hamdullah
Published: September 2010

The combination of the oxidants produces the active species tert.‐butyloxidanyl which allows a direct conversion of the substrates to carbonyl derivatives.
ChemInform Abstract: Activation of C—F Bonds in Preference to C—I Bonds: Difluoromethylation of Lithium Enolates with Trifluoromethyl Iodide.
Authors: Mikami Koichi , Tomita Yuichi , Itoh Yoshimitsu
Published: September 2010

The reaction represents an unprecedented construction of the all‐carbon quarternary centers using lithium enolates and gaseous CF3I without any metal catalysts.
ChemInform Abstract: Retro‐Claisen Condensation with FeIII as Catalyst under Solvent‐Free Conditions.
Authors: Rao Chitturi Bhujanga , Rao Dasireddi Chandra , Babu Dokuburra Chanti , Venkateswarlu Yenamandra
Published: September 2010

A solvent‐free, inexpensive, and commercially available ferric chloride catalyzed synthesis of esters is reported.
ChemInform Abstract: Convenient and Efficient Method for the Synthesis of N‐Heteroaryl Aminonaphthols under Solvent‐Free Conditions.
Authors: Olyaei Abolfazi , Raoufmoghaddam Saeed Raoufmoghaddam Saeed , Sadeghpour Mahdieh , Ebadzadeh Behruz
Published: September 2010

A quick, convenient and efficient one‐pot, three‐component approach to racemic Betti bases (IV) is reported.
ChemInform Abstract: Preparation and Reactions of (β‐Trifluoromethyl)vinyl Sulfonium Salt.
Authors: Maeda Ryoko , Ooyama Kyoko , Anno Ryoko , Shiosaki Masahiro , Azema Takayuki , Hanamoto Takeshi
Published: September 2010

A facile preparation of title salts (III) is developed.
ChemInform Abstract: Convenient Synthesis of Allylic Thioethers from Phosphorothioate Esters and Alcohols.
Authors: Robertson Forest , Wu Jimmy
Published: September 2010

The preparation of the important substructures is complete in one step and includes an enantioenriched derivative (XI).
ChemInform Abstract: Asymmetric Synthesis of Cyclic cis‐β‐Amino Acid Derivatives Using Sulfinimines and Prochiral Weinreb Amide Enolates.
Authors: Davis Franklin A. , Theddu Naresh
Published: September 2010

A new and highly stereoselective method to prepare 5‐, 6‐, and 7‐membered cyclic cis‐β‐amino acid derivatives is reported.
ChemInform Abstract: A P,N‐Ligand for Palladium‐Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions.
Authors: Lundgren Rylan J. , Peters Brendan D. , Alsabeh Pamela G. , Stradiotto Mark
Published: September 2010

A new air‐stable P,N‐ligand is used in the palladium‐catalyzed cross‐coupling of ammonia to a variety of aryl chlorides with high chemoselectivity.
ChemInform Abstract: Pd(II)‐Catalyzed o‐C—H Acetoxylation of Phenylalanine and Ephedrine Derivatives with MeCOOOtBu/Ac2O.
Authors: Vickers Chris J. , Mei Tian‐Sheng , Yu Jin‐Quan
Published: September 2010

A new protocol is applied to various triflamide substrates tolerating a broad spectrum of functional groups.
ChemInform Abstract: Highly Efficient and Regioselective Allylation with Allylic Alcohols Catalyzed by [Mo3S4Pd(η3‐Allyl)] Clusters.
Authors: Tao Yinsong , Wang Bo , Wang Baomin , Qu Lihong , Qu Jingping
Published: September 2010

Allylation reaction of primary and secondary amines as well as linear and cyclic active methylene compounds with allyl alcohol (II) is catalyzed by a novel catalyst‐cluster.
ChemInform Abstract: Pyrrolidinyl—Camphor Derivatives as a New Class of Organocatalyst for Direct Asymmetric Michael Addition of Aldehydes and Ketones to β‐Nitroalkenes.
Authors: Ting Ying‐Fang , Chang Chihliang , Reddy Raju Jannapu , Magar Dhananjay R. , Chen Kwunmin
Published: September 2010

The synthetical utility is demonstrated by the synthesis of a tetrasubstituted (XIX) starting from (S)‐citronellal (XVII) with high selectivity.
ChemInform Abstract: Copper Catalyzed Arylation/C—C Bond Activation: An Approach Toward α‐Aryl Ketones.
Authors: He Chuan , Guo Sheng , Huang Li , Lei Aiwen
Published: September 2010

A wide range of α‐aryl ketones is prepared from the aryl iodides or bromides with β‐diketones.
ChemInform Abstract: Palladium Nanoparticle Catalyzed Hiyama Coupling Reaction of Benzyl Halides.
Authors: Srimani Dipankar , Bej Ansuman , Sarkar Amitabha
Published: September 2010

Treatment of benzylic halides and tosylates with aryltrialkoxysilanes in the presence of Pd nanoparticles, generated in situ, provides a new and efficient approach to diarylmethanes.
ChemInform Abstract: A Convenient Synthetic Route to Furan Esters and Lactones by Palladium‐Catalyzed Carboalkoxylation or Cyclocarbonylation of Hydroxyl‐Substituted 3‐Iodofurans.
Authors: Cho Chul‐Hee , Larock Richard C.
Published: September 2010

Optimized conditions are evaluated for the synthesis of 3‐iodofurans of type (III).
ChemInform Abstract: New Chiral N‐Heterocyclic Carbene Ligands in Palladium‐Catalyzed α‐Arylations of Amides: Conformational Locking Through Allylic Strain as a Device for Stereocontrol.
Authors: Jia Yi‐Xia , Katayev Dmitry , Bernardinelli Gerald , Seidel Thomas M. , Kuendig E. Peter
Published: September 2010

to be continued
ChemInform Abstract: Facile Synthesis of 2,2‐Bis(1H‐indol‐3‐yl)acenaphthen‐1(2H)‐one Derivatives Catalyzed by Ceric Ammonium Nitrate.
Authors: Feng Guo‐Liang
Published: September 2010

Unsymmetrically 2,2‐bis(indolyl) substituted products can be obtained in the same way using previously described 2‐hydroxy‐2‐indolyl substituted acenaphthene‐1‐(2H)‐ones as precursor.
ChemInform Abstract: Synthesis of Some 5‐Phenylisoxazole‐3‐carboxylic Acid Derivatives as Potent Xanthine Oxidase Inhibitors.
Authors: Wang Shaojie , Yan Jufang , Wang Jian , Chen Jiarun , Zhang Tingjian , Zhao Yong , Xue Mingxing
Published: September 2010

A molecular modeling study is performed on the most promising compound (Va) to gain an insight into its binding mode with xanthine oxidase (XO) and to provide the basis for further structure‐guided design of new XO inhibitors.
ChemInform Abstract: Ru(III)‐Catalyzed Oxidative Reaction in Ionic Liquid: An Efficient and Practical Route to 2‐Substituted Benzothiazoles and Their Hybrids with Pyrimidine Nucleoside.
Authors: Fan Xuesan , Wang Yangyang , He Yan , Zhang Xinying , Wang Jianji
Published: September 2010

The condensation of 2‐aminothiophenols with aldehydes under conditions A) provides a series of products with antimicrobial activity.
ChemInform Abstract: Rapid and Facile Synthesis of Spiro[indole‐3,3′‐[1,2,4]triazol]‐2(1H)‐ones.
Authors: Mohamed Ashraf M. , Alsharari Musaed A. , Aly Ashraf A.
Published: September 2010

With a view to obtaining pharmacologically active compounds the title triazoles are prepared.
ChemInform Abstract: Synthesis and Antimicrobial Study of 1,2,4‐Triazole, Quinazoline and Benzothiazole Derivatives from 1‐Naphthoylisothiocyanate.
Authors: Hemdan Magdy M. , Fahmy Amin F. , El‐Sayed Amira A.
Published: September 2010

Novel naphthyl‐substituted derivatives are tested for their antimicrobial activity against Gram‐positive (Bacillus subtilis) and Gram‐negative (E.
ChemInform Abstract: A Convenient Strategy for the Synthesis of 3,5‐Diaryl‐1,2,4‐thiadiazoles: Oxidative Dimerization of Arylthioamides Using CC‐DMSO in PEG‐400.
Authors: Khosropour Ahmad Reza , Noei Jalil
Published: September 2010

The title compounds (II) are obtained in a green media using cyanuric chloride (CC) DMSO as inexpensive and highly efficient promoter system.
ChemInform Abstract: A Rapid and Efficient Method for the Synthesis of 14H‐Dibenzo[α.j]xanthenes, Aryl‐5H‐dibenzo[b.i]xanthene‐5,7,12,14‐(13H)‐tetraone and 1,8‐Dioxo‐octahydroxanthenes by Acidic Ionic Liquid.
Authors: Rahmati Abbas
Published: September 2010

The clean synthesis is achieved using TFA as the catalyst in tetramethylguanidinium trifluoracetate ionic liquid.
ChemInform Abstract: Asymmetric 1,4‐Addition of Arylboronic Acids to 2,3‐Dihydro‐4‐pyridones Catalyzed by Axially Chiral NHC—Pd(II) Complexes.
Authors: Xu Qin , Zhang Rui , Zhang Tao , Shi Min
Published: September 2010

The Pd compounds PHC and PNC promote efficiently the addition of arylboronic acids (II) to dihydropyridones and other cyclic enones.
ChemInform Abstract: Asymmetric Three‐Component Inverse Electron‐Demand Aza‐Diels—Alder Reaction: Efficient Synthesis of Ring‐Fused Tetrahydroquinolines.
Authors: Xie Mingsheng , Chen Xiaohong , Zhu Yin , Gao Bo , Lin Lili , Liu Xiaohua , Feng Xiaoming
Published: September 2010

The reaction of aromatic and aliphatic aldehydes, 2‐aminophenols and cyclopentadiene (III) is catalyzed by Sc(OTf)3 and a chiral N,N′‐dioxide catalysts to afford the target tricyclic products with high yields and selectivities.
ChemInform Abstract: Synthesis and Spectral Properties of 4‐Amino‐ and 4‐Acetylamino‐N‐arylnaphthalimides Containing Electron‐Donating Groups in the N‐Aryl Substituent.
Authors: Panchenko P. A. , Fedorov Yu. V. , Fedorova O. A. , Perevalov V. P. , Jonusauskas G.
Published: September 2010

It is shown that introduction of electron‐donating alkoxy groups into the benzene ring of the N‐aryl fragment leads to fluorescence quenching of the naphthalimide chromophore.
ChemInform Abstract: Bicyclic Compounds Obtained by the Biginelli Reaction.
Authors: Kurbanova M. M.
Published: September 2010

Three‐component reaction of 5‐bromosalicylaldehyde (I) with 1,3‐dicarbonyl compounds (II) and urea derivatives (III) gives the expected pyrimidine derivatives (IV) or bicyclic compounds (V) depending on the reaction conditions.
ChemInform Abstract: Fluorine‐Containing Quinazolines Annulated at the Pyrimidine Ring.
Authors: Nosova E. V. , Laeva A. A. , Trashakhova T. V. , Lipunova G. N. , Slepukhin P. A. , Charushin V. N.
Published: September 2010

The title compounds are synthesized by the reaction of 2‐ and 4‐hydrazino‐substituted quinazolines with aldehydes and subsequent oxidative cyclization or by alkylation of 2‐alkylthio‐4(3H)‐quinazolinones with bromoethanol and ipso‐substitution of the alkylthio group.
ChemInform Abstract: The Asymmetric Synthesis of Sitagliptin, a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes.
Authors: Liu Feng , Yu Wansheng , Ou Wenhua , Wang Xiaoke , Ruan Libo , Li Yiming , Peng Xijiang , Tao Xiaohu , Pan Xianhua
Published: September 2010

Key step in the improved synthetic pathway to sitagliptin (VII), a new DPP‐IV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).
ChemInform Abstract: Synthesis and Antiproliferative Activity of Oxazinocarbazole and N,N‐Bis(carbazolylmethyl)amine Derivatives.
Authors: Issa Samar , Walchshofer Nadia , Kassab Issam , Termoss Hussein , Chamat Soulaima , Geahchan Aziz , Bouaziz Zouhair
Published: September 2010

Twentyfour oxazinocarbazoles (IV) are prepared by a Mannich type condensation of N‐substituted hydroxycarbazoles (I) with formaldehyde (II) and primary amines (III).
ChemInform Abstract: Silver‐Catalyzed Tandem Ammonolysis—Cyclization of 2‐Alkynylbenzenamines with Tetraalkylthiuram Disulfides to 4‐Methylene‐4H‐benzo[d][1,3]thiazin‐2‐amines.
Authors: Tang Ri‐Yuan , Luo Pei‐Song , Zhang Xing‐Guo , Zhong Ping , Li Jin‐Heng
Published: September 2010

Disulfides (IIa) and (IIb) afford exclusively the (Z)‐products on reaction with substrate (Ia/Ib).
ChemInform Abstract: Synthesis and Biological Evaluation of New [1,2,4]Triazino[5,6‐b]indol‐3‐ylthio‐1,3,5‐triazines and [1,2,4]Triazino[5,6‐b]indol‐3‐ylthio‐pyrimidines Against Leishmania donovani.
Authors: Gupta Leena , Sunduru Naresh , Verma Aditya , Srivastava Saumya , Gupta Suman , Goyal Neena , Chauhan Prem M. S.
Published: September 2010

Triazinoindoletriazine derivatives (VII) and triazinopyrimidine derivatives (X) are synthesized via cyclization of protected isatin (I) with thiosemicarbazide (II) and nucleophilic substitution of intermediates (V) and (IX) with amines, e.g. (VI).
ChemInform Abstract: Ester‐Directed Regioselective Borylation of Heteroarenes Catalyzed by a Silica‐Supported Iridium Complex.
Authors: Kawamorita Soichiro , Ohmiya Hirohisa , Sawamura Masaya
Published: September 2010

Heteroarenes bearing an ester substituent undergo regioselective borylation at the position adjacent to the ester group.
ChemInform Abstract: Ambient‐Temperature Cobalt‐Catalyzed Cycloaddition Strategies to Aromatic Boronic Esters.
Authors: Auvinet Anne‐Laure , Harrity Joseph P. A. , Hilt Gerhard
Published: September 2010

Two convenient methods are reported.
ChemInform Abstract: Polyfused Nitrogen‐Containing Heterocycles. Part 23. Methyl 4‐Hydroxy‐3‐phenyl‐5‐phenyl (alkyl)‐2‐phenyliminoselenazolidine‐4‐carboxylates and Selenazolo[3,4‐a]quinoxalin‐4(5H)‐one Derivatives on Their Basis.
Authors: Mamedov V. A. , Zhukova N. A. , Gubaidullin A. T. , Beschastnova T. N. , Rizvanov I. Kh. , Levin Ya. A. , Litvinov I. A.
Published: September 2010

The condensation of halopyrotartrates (I) with N,N′‐diphenylselenourea (II) leads to carboxylates (III) which undergo reaction with various 1,2‐phenylenediamines giving selenazolo[3,4‐a]quinoxalin‐4(5H)‐one derivatives.
ChemInform Abstract: Synthesis of Diorganyl Selenides Mediated by Zinc in Ionic Liquid.
Authors: Narayanaperumal Senthil , Alberto Eduardo E. , Gul Kashif , Rodrigues Oscar E. D. , Braga Antonio L.
Published: September 2010

A new, simple, mild, and efficient method to prepare diorganyl selenides is reported.
ChemInform Abstract: Synthesis and Evaluation of 9‐Benzylideneamino Derivatives of Homocamptothecin as Potent Inhibitors of DNA Topoisomerase I.
Authors: Miao Zhenyuan , et al. et al.
Published: September 2010

Friedlaender cyclization of the previously described key intermediate (II) with acetamide (I) and reaction of (IV) with substituted benzaldehydes (V) afford thirteen novel benzylideneamino derivatives of homocamptothecin.
ChemInform Abstract: Concise Formal Synthesis of (‐)‐Salinosporamide A (Marizomib) (IV) Using a Regio‐ and Stereoselective Epoxidation and Reductive Oxirane Ring‐Opening Strategy.
Authors: Ling Taotao , Potts Barbara C. , Macherla Venkat R.
Published: September 2010

The key steps are stereoselective epoxidation of the alkene (I) and subsequent regio‐ and stereoselective oxirane ring‐opening.
ChemInform Abstract: Efficient Total Synthesis of (S)‐14‐Azacamptothecin.
Authors: Liu Guan‐Sai , Yao Yuan‐Shan , Xu Peng , Wang Shaozhong , Yao Zhu‐Jun
Published: September 2010

A mild Hendrickson reagent triggered intramolecular cascade cyclization, a highly enantioselective dihydroxylation, and an efficient palladium‐catalyzed migration of O‐allyl to N‐allyl are employed as the key steps in this work.
ChemInform Abstract: (—)‐Carbodine: Enantiomeric Synthesis and in vitro Antiviral Activity Against Various Strains of Influenza Virus Including H5N1 (Avian Influenza) and Novel 2009 H1N1 (Swine Flu).
Authors: Rao Jagadeeshwar R. , Jha Ashok K. , Rawal Ravindra K. , Sharon Ashoke , Day Craig W. , Barnard Dale L. , Smee Donald F. , Chu Chung K.
Published: September 2010

The enantiomerically pure cyclopentyl cytosine, (‐)‐carbodine (VI), is synthesized and evaluated for its in vitro antiinfluenza activity in comparison to its racemate and (+)‐enantiomer.
ChemInform Abstract: Synthesis of 1H‐Indole‐2,3‐dione‐3‐thiosemicarbazone Ribonucleosides as Antibacterial Agents.
Authors: Kassab Shaymaa E. , Hegazy Gehan H. , Eid Nahed M. , Amin Kamelia M. , El‐Gendy Adel A.
Published: September 2010

All synthesized compounds exhibit slight inhibitory activity against some bacterial strains.
ChemInform Abstract: Efficient Synthesis of Clofarabine and Gemcitabine from 2‐Deoxyribonolactone.
Authors: Cen Yana , Sauve Anthony A.
Published: September 2010

New syntheses of clofarabine (VI) and gemcitabine (X) based on a previously described electrophilic fluorination method for the synthesis of 2‐fluoro furanose derivatives are described.
ChemInform Abstract: Pyrimidine‐Purine and Pyrimidine Heterodinucleosides Synthesis Containing a Triazole Linkage.
Authors: Lucas R. , Elchinger P. H. , Faugeras P. A. , Zerrouki R.
Published: September 2010

The triazole heterodimers (V) and (VIII) are synthesized involving a click chemistry reaction and microwave irradiation.
ChemInform Abstract: Synthesis and Molecular Docking Studies of 1‐Phenyl‐4‐glycosyl‐dihydropyridines as Potent Antileishmanial Agents.
Authors: Pandey Vivek Parashar , Bisht Surendra Singh , Mishra Mridul , Kumar Ashutosh , Siddiqi Mohammad Imran , Verma Aditya , Mittal Monika , Sane Shraddha A. , Gupta Suman , Tripathi Rama P.
Published: September 2010

The one‐pot multicomponent reaction of xylofuranosyl dialdoses (I) with β‐keto compounds (II) and anilines (III) affords the pentofuranosyldihydropyridines (IV) in good yields.
ChemInform Abstract: Enantioselective Synthesis of (1E,3S)‐1‐Iodoundec‐1‐en‐5‐yn‐3‐ol (III), the Eicosanoid Synthon
Authors: Lapitskaya M. A. , Vasiljeva L. L. , Pivnitsky K. K.
Published: September 2010

based on the S‐enantiodirected dihydroxylation of enyne (I)
ChemInform Abstract: Formal Total Syntheses of (+)‐Prelaureatin (IV) and (+)‐Laurallene (V) by Diastereoselective Brook Rearrangement Mediated [3 + 4] Annulation.
Authors: Sasaki Michiko , Oyamada Kazuhisa , Takeda Kei
Published: September 2010

The synthesis of the title compounds is achieved via highly stereoselective cycloaddition of the silane (II) to the cyclic enone (I).