bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on Real-Time Monitoring and Performance Optimization of Suspension System in Maglev Train
Authors: Zhou Xu , Wen Tao , Long Zhiqiang
Published: December 2021

With the success of the commercial operation of the maglev train, the demand for real-time monitoring and high-performance control of the maglev train suspension system is also increasing. Therefore, a framework for performance monitoring and performance optimization of the maglev train suspension system is proposed in this article. This framework consists of four parts: plant, feedback controller, residual generator, and dynamic compensator. Firstly, after the system model is established, the nominal controller is designed to ensure the stability of the system. Secondly, the observer-based residual generator is identified offline based on the input and output data without knowing the accurate model of the system, which avoids the interference of the unmodeled part. Thirdly, the control performance is monitored and evaluated in real time by analyzing the residual and executing the judgment logic. Fourthly, when the control performance of the system is degraded or not satisfactory, the dynamic compensator based on the residual is updated online iteratively to optimize the control performance. Finally, the proposed framework and theory are verified on the single suspension experimental platform and the results show the effectiveness.
Silesian Painters and Sculptors at the Vienna Academy of Fine Arts in the Years 1726–1780. A Contribution to the History of Academism in the Early Modern Period
Authors: Kolbiarz Artur
Published: December 2021

The Vienna Academy was the most important art academy for German-speaking artists in the Baroque period. It shaped the development of art in the capital of the Habsburg monarchy as well as on its periphery, including in Silesia, yet the relationships between Silesian sculptors and painters and the Vienna Academy have been overlooked by scholars. Research in the Academy archives sheds light on a number of important issues related to the social, economic, and artistic aspects of the education and the subsequent activities of Vienna Academy alumni. Surviving student registers record the names of Silesian painters and sculptors studying in Vienna and offer insights into other aspects of education at the Academy.
The Interventricular Septum Is Biomechanically Distinct from the Ventricular Free Walls
Authors: Nguyen-Truong Michael , Liu Wenqiang , Doherty Courtney , LeBar Kristen , Labus Kevin , Puttlitz Christian , Easley Jeremiah , Monnet Eric , Chicco Adam , Wang Zhijie
Published: December 2021

The interventricular septum contributes to the pumping function of both ventricles. However, unlike the ventricular wall, its mechanical behavior remains largely unknown. To fill the knowledge gap, this study aims to characterize the biaxial and transmural variation of the mechanical properties of the septum and compare it to the free walls of the left and right ventricles (LV/RV). Fresh hearts were obtained from healthy, adult sheep. The septal wall was sliced along the mid-line into two septal sides and compared to the epicardial layers of the LV- and RV-free walls. Biaxial tensile mechanical tests and constitutive modeling were performed to obtain the passive mechanical properties of the LV- and RV-side of the septum and ventricular walls. We found that both sides of the septum were significantly softer than the respective ventricular walls, and that the septum presented significantly less collagen than the ventricular walls. At low strains, we observed the symmetric distribution of the fiber orientations and a similar anisotropic behavior between the LV-side and RV-side of the septum, with a stiffer material property in the longitudinal direction, rather than the circumferential direction. At high strains, both sides showed isotropic behavior. Both septal sides had similar intrinsic elasticity, as evidenced by experimental data and constitutive modeling. These new findings offer important knowledge of the biomechanics of the septum wall, which may deepen the understanding of heart physiology.
Improving the Substrate Affinity and Catalytic Efficiency of β-Glucosidase Bgl3A from Talaromyces leycettanus JCM12802 by Rational Design
Authors: Xia Wei , Bai Yingguo , Shi Pengjun
Published: December 2021

Improving the substrate affinity and catalytic efficiency of β-glucosidase is necessary for better performance in the enzymatic saccharification of cellulosic biomass because of its ability to prevent cellobiose inhibition on cellulases. Bgl3A from Talaromyces leycettanus JCM12802, identified in our previous work, was considered a suitable candidate enzyme for efficient cellulose saccharification with higher catalytic efficiency on the natural substrate cellobiose compared with other β-glucosidase but showed insufficient substrate affinity. In this work, hydrophobic stacking interaction and hydrogen-bonding networks in the active center of Bgl3A were analyzed and rationally designed to strengthen substrate binding. Three vital residues, Met36, Phe66, and Glu168, which were supposed to influence substrate binding by stabilizing adjacent binding site, were chosen for mutagenesis. The results indicated that strengthening the hydrophobic interaction between stacking aromatic residue and the substrate, and stabilizing the hydrogen-bonding networks in the binding pocket could contribute to the stabilized substrate combination. Four dominant mutants, M36E, M36N, F66Y, and E168Q with significantly lower Km values and 1.4–2.3-fold catalytic efficiencies, were obtained. These findings may provide a valuable reference for the design of other β-glucosidases and even glycoside hydrolases.
Amyloid Fragmentation and Disaggregation in Yeast and Animals
Authors: Kushnirov Vitaly V. , Dergalev Alexander A. , Alexandrov Alexander I.
Published: December 2021

Amyloids are filamentous protein aggregates that are associated with a number of incurable diseases, termed amyloidoses. Amyloids can also manifest as infectious or heritable particles, known as prions. While just one prion is known in humans and animals, more than ten prion amyloids have been discovered in fungi. The propagation of fungal prion amyloids requires the chaperone Hsp104, though in excess it can eliminate some prions. Even though Hsp104 acts to disassemble prion fibrils, at normal levels it fragments them into multiple smaller pieces, which ensures prion propagation and accelerates prion conversion. Animals lack Hsp104, but disaggregation is performed by the same complement of chaperones that assist Hsp104 in yeast—Hsp40, Hsp70, and Hsp110. Exogenous Hsp104 can efficiently cooperate with these chaperones in animals and promotes disaggregation, especially of large amyloid aggregates, which indicates its potential as a treatment for amyloid diseases. However, despite the significant effects, Hsp104 and its potentiated variants may be insufficient to fully dissolve amyloid. In this review, we consider chaperone mechanisms acting to disassemble heritable protein aggregates in yeast and animals, and their potential use in the therapy of human amyloid diseases.
Four Seasons for Schwann Cell Biology, Revisiting Key Periods: Development, Homeostasis, Repair, and Aging
Authors: Sardella-Silva Gabriela , Mietto Bruno Siqueira , Ribeiro-Resende Victor Túlio
Published: December 2021

Like the seasons of the year, all natural things happen in stages, going through adaptations when challenged, and Schwann cells are a great example of that. During maturation, these cells regulate several steps in peripheral nervous system development. The Spring of the cell means the rise and bloom through organized stages defined by time-dependent regulation of factors and microenvironmental influences. Once matured, the Summer of the cell begins: a high energy stage focused on maintaining adult homeostasis. The Schwann cell provides many neuron-glia communications resulting in the maintenance of synapses. In the peripheral nervous system, Schwann cells are pivotal after injuries, balancing degeneration and regeneration, similarly to when Autumn comes. Their ability to acquire a repair phenotype brings the potential to reconnect axons to targets and regain function. Finally, Schwann cells age, not only by growing old, but also by imposed environmental cues, like loss of function induced by pathologies. The Winter of the cell presents as reduced activity, especially regarding their role in repair; this reflects on the regenerative potential of older/less healthy individuals. This review gathers essential information about Schwann cells in different stages, summarizing important participation of this intriguing cell in many functions throughout its lifetime.
Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications
Authors: Zai Wenjing , Chen Wei , Liu Hongrui , Ju Dianwen
Published: December 2021

Nonalcoholic fatty liver disease (NAFLD) represents one of the most common liver disorders and can progress into a series of liver diseases, including nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even liver cancer. Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is predominantly produced by lymphocytes but acts exclusively on epithelial cells. IL-22 was proven to favor tissue protection and regeneration in multiple diseases. Emerging evidence suggests that IL-22 plays important protective functions against NAFLD by improving insulin sensitivity, modulating lipid metabolism, relieving oxidative and endoplasmic reticulum (ER) stress, and inhibiting apoptosis. By directly interacting with the heterodimeric IL-10R2 and IL-22R1 receptor complex on hepatocytes, IL-22 activates the Janus kinase 1 (JAK1)/ signal transducer and activator of transcription 3 (STAT3), c-Jun N-terminal kinase (JNK) and extracellular-signal regulated kinase (ERK) pathways to regulate the subsequent expression of genes involved in inflammation, metabolism, tissue repair, and regeneration, thus alleviating hepatitis and steatosis. However, due to the wide biodistribution of the IL-22 receptor and its proinflammatory effects, modifications such as targeted delivery of IL-22 expression and recombinant IL-22 fusion proteins to improve its efficacy while reducing systemic side effects should be taken for further clinical application. In this review, we summarized recent progress in understanding the physiological and pathological importance of the IL-22-IL-22R axis in NAFLD and the mechanisms of IL-22 in the protection of NAFLD and discussed the potential strategies to maneuver this specific cytokine for therapeutic applications for NAFLD.
Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
Authors: Sanjay Sanjay , Sharma Anshul , Lee Hae-Jeung
Published: December 2021

Peroxisome proliferator-activated receptors (PPAR-γ, PPAR-α, and PPAR-β/δ) are ligand-dependent nuclear receptors that play a critical role in the regulation of hundreds of genes through their activation. Their expression and targeted activation play an important role in the treatment of a variety of diseases, including neurodegenerative, cardiovascular, diabetes, and cancer. In recent years, several reviews have been published describing the therapeutic potential of PPAR agonists (natural or synthetic) in the disorders listed above; however, no comprehensive report defining the role of naturally derived phytoconstituents as PPAR agonists targeting neurodegenerative diseases has been published. This review will focus on the role of phytoconstituents as PPAR agonists and the relevant preclinical studies and mechanistic insights into their neuroprotective effects. Exemplary research includes flavonoids, fatty acids, cannabinoids, curcumin, genistein, capsaicin, and piperine, all of which have been shown to be PPAR agonists either directly or indirectly. Additionally, a few studies have demonstrated the use of clinical samples in in vitro investigations. The role of the fruit fly Drosophila melanogaster as a potential model for studying neurodegenerative diseases has also been highlighted.
Metabolic Fatty Liver Disease in Children: A Growing Public Health Problem
Authors: Le Garf Sébastien , Nègre Véronique , Anty Rodolphe , Gual Philippe
Published: December 2021

Metabolic-associated fatty liver disease (MAFLD), previously called nonalcoholic fatty liver diseases (NAFLD), is one of the most important causes of chronic liver disease worldwide and will likely become the leading cause of end-stage liver disease in the decades ahead. MAFLD covers a continuum of liver diseases from fatty liver to nonalcoholic steatohepatitis (NASH), liver fibrosis/cirrhosis and hepatocellular cancer. Importantly, the growing incidence of overweight and obesity in childhood, 4% in 1975 to 18% in 2016, with persisting obesity complications into adulthood, is likely to be harmful by increasing the incidence of severe MAFLD at an earlier age. Currently, MAFLD is the leading form of chronic liver disease in children and adolescents, with a global prevalence of 3 to 10%, pointing out that early diagnosis is therefore crucial. In this review, we highlight the current knowledge concerning the epidemiology, risk factors and potential pathogenic mechanisms, as well as diagnostic and therapeutic approaches, of pediatric MAFLD.
A Study on Electron Acceptor of Carbonaceous Materials for Highly Efficient Hydrogen Uptakes
Authors: Lee Seul-Yi , Park Ji-Hye , Heo Young-Jung , Lee Eun-Sang , Park Soo-Jin
Published: December 2021

Significant efforts have been directed toward the identification of carbonaceous materials that can be utilized for hydrogen uptake in order to develop on-board automotive systems with a gravimetric capacity of 5.5 wt.%, thus meeting the U.S. Department of Energy technical targets. However, the capacity of hydrogen storage is limited by the weak interaction between hydrogen molecules and the carbon surface. Cigarette butts, which are the most abundant form of primary plastic waste, remain an intractable environmental pollution problem. To transform this source of waste into a valuable adsorbent for hydrogen uptake, we prepared several forms of oxygen-rich cigarette butt-derived porous carbon (CGB-AC, with the activation temperature range of 600 and 900 °C). Our experimental investigation revealed that the specific surface area increased from 600 to 700 °C and then decreased as the temperature rose to 900 °C. In contrast, the oxygen contents gradually decreased with increasing activation temperature. CGB-AC700 had the highest H2 excess uptake (QExcess) of 8.54 wt.% at 77 K and 20 bar, which was much higher than that of porous carbon reported in the previous studies. We found that the dynamic interaction between the porosity and the oxygen content determined the hydrogen storage capacity. The underlying mechanisms proposed in the present study would be useful in the design of efficient hydrogen storage because they explain the interaction between positive carbonaceous materials and negative hydrogen molecules in quadrupole orbitals.
Double-Stranded RNA Structural Elements Holding the Key to Translational Regulation in Cancer: The Case of Editing in RNA-Binding Motif Protein 8A
Authors: Abukar Asra , Wipplinger Martin , Hariharan Ananya , Sun Suna , Ronner Manuel , Sculco Marika , Okonska Agata , Kresoja-Rakic Jelena , Rehrauer Hubert , Qi Weihong , Beusechem Victor W. , Felley-Bosco Emanuela
Published: December 2021

Mesothelioma is an aggressive cancer associated with asbestos exposure. RNA-binding motif protein 8a (RBM8A) mRNA editing increases in mouse tissues upon asbestos exposure. The aim of this study was to further characterize the role of RBM8A in mesothelioma and the consequences of its mRNA editing. RBM8A protein expression was higher in mesothelioma compared to mesothelial cells. Silencing RBM8A changed splicing patterns in mesothelial and mesothelioma cells but drastically reduced viability only in mesothelioma cells. In the tissues of asbestos-exposed mice, editing of Rbm8a mRNA was associated with increased protein immunoreactivity, with no change in mRNA levels. Increased adenosine deaminase acting on dsRNA (ADAR)-dependent editing of Alu elements in the RBM8A 3′UTR was observed in mesothelioma cells compared to mesothelial cells. Editing stabilized protein expression. The unedited RBM8A 3′UTR had a stronger interaction with Musashi (MSI) compared to the edited form. The silencing of MSI2 in mesothelioma or overexpression of Adar2 in mesothelial cells resulted in increased RBM8A protein levels. Therefore, ADAR-dependent editing contributes to maintaining elevated RBM8A protein levels in mesothelioma by counteracting MSI2-driven downregulation. A wider implication of this mechanism for the translational control of protein expression is suggested by the editing of similarly structured Alu elements in several other transcripts.
The EU Strategy on the Rights of the Child and the European Child Guarantee—Evidence-Based Recommendations for Alternative Care
Authors: Sacur Bárbara Mourão , Diogo Elisete
Published: December 2021

Protection and promotion of child rights are referred to as a central purpose of the European Union (EU). Therefore in 2021, the EU Strategy on the Rights of the Child and the European Child Guarantee were published to enable children to have the best possible life in the EU and worldwide. Member states were invited to implement the directions of both documents into practice. The present study analyses and showcases the evidence on how to progress implementation of the Strategy and the Guarantee regarding alternative care in Portugal. A literature review was conducted based on international literature. Evidence-based recommendations for the Portuguese transition process towards quality, family and community-based care are stated. De-institutionalisation and strengthening specific services—kinship care, special guardianship, and foster care—are advocated, namely specialising the workforce, and promoting training for kinship carers and prospective special guardians. To conclude, the revision and monitoring of the measures for children in need of alternative care are suggested as well as integrating and publishing data from the diverse services of the alternative care system.
Ultra-Low-Reflective, Self-Cleaning Surface by Fabrication Dual-Scale Hierarchical Optical Structures on Silicon
Authors: Duan Miaomiao , Wu Jingjun , Zhang Yubin , Zhang Ning , Chen Jun , Lei Zhenhua , Yi Zao , Ye Xin
Published: December 2021

An integrated functional anti-reflective surface is of great significance for optical and optoelectronic devices. Hence, its preparation has attracted great attention from many researchers. This study combined wet alkaline etching approaches and reactive ion etching (RIE) techniques to create a dual-scale hierarchical anti-reflective surface on silicon substrates. The effect of RIE time on surface morphology and optical performance was investigated using multiple characterization forms. The optimal parameters for the fabrication of dual-scale structures by the composite etching process were explored. The silicon surface with a dual-scale structure indicated excellent anti-reflective properties (minimum reflectivity of 0.9%) in the 300 to 1100 nm wavelength range. In addition, the ultra-low reflection characteristic of the surface remained prominent at incident light angles up to 60°. The simulated spectra using the finite difference time domain (FDTD) method agreed with the experimental results. Superhydrophobicity and self-cleaning were also attractive properties of the surface. The functionally integrated surface enables silicon devices to have broad application prospects in solar cells, light emitting diodes (LEDs), photoelectric detectors, and outdoor equipment.
Observation of a New Polyhalide Phase in Ag-Cl2 System at High Pressure
Authors: Grzelak Adam , Gawraczyński Jakub , Derzsi Mariana , Struzhkin Viktor , Somayazulu Maddury , Grochala Wojciech
Published: December 2021

In this short contribution, we examine Raman spectroscopic data from high-pressure and high-temperature experiments with an Ag-Cl2 system, and find that they are in good agreement with previously observed and calculated spectra of polychloride species. Our results imply the formation of a hitherto unknown AgClx compound, which warrants further study.
Taxonomic Revision of Eastern Part of Western Palaearctic Cordulegaster Using Molecular Phylogeny and Morphology, with the Description of Two New Species (Odonata: Anisoptera: Cordulegastridae)
Authors: Schneider Thomas , Vierstraete Andy , Müller Ole , van Pelt Gert Jan , Caspers Max , Ikemeyer Dietmar , Snegovaya Nataly , Dumont Henri J.
Published: December 2021

Taxonomy of the genus Cordulegaster Leach in Brewster, 1815 in the Eastern part of the Western Palaearctic is poorly resolved. A two-step approach was applied: sequences of mitochondrial and nuclear DNA fragments were used to sort specimens; poorly known or new taxa with their phenotypic variation were described. The existence of two traditional groups (boltonii- and bidentata-group) was confirmed. Cordulegaster coronata Morton, 1916, however, belongs to a different group. Molecular-analysis supported three known and one new species (C. heros Theischinger, 1979, C. picta Selys, 1854, C. vanbrinkae Lohmann, 1993, and C. kalkmani sp. nov.) in the boltonii-group. In the bidentata-group, all specimens from West-Turkey belonged to C. insignis Schneider, 1845, all specimens further east to a complex of four closely related species, which we name charpentieri-complex (C. amasina Morton, 1916, stat. rev., C. mzymtae Bartenev, 1929 C. charpentieri (Kolenati, 1846), stat. rev. and C. cilicia sp. nov.). The following taxa: C. insignis nobilis Morton, 1916, syn. nov., C. nachitschevanica Skvortsov and Snegovaya, 2015, syn. nov. C. plagionyx Skvortsov and Snegovaya, 2015, syn. nov. and the Caucasian subspecies C. insignis lagodechica Bartenev, 1930, syn. nov., were synonymized with C. charpentieri. Finally, we provide a key for all Western Palaearctic Cordulegaster.
SCORE2 Assessment in the Calculation of Cardiovascular Risk in Patients with Rheumatoid Arthritis
Authors: Ferraz-Amaro Iván , Corrales Alfonso , Atienza-Mateo Belén , Vegas-Revenga Nuria , Prieto-Peña Diana , Sánchez-Martín Julio , Almeida Cristina , Quevedo-Abeledo Juan Carlos , Blanco Ricardo , González-Gay Miguel Á.
Published: December 2021

Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease (CVD). Risk chart algorithms, such as the Systematic Coronary Risk Assessment (SCORE), often underestimate the risk of CVD in patients with RA. In this sense, the use of noninvasive tools, such as the carotid ultrasound, has made it possible to identify RA patients at high risk of CVD who had subclinical atherosclerosis disease and who had been included in the low or moderate CVD risk categories when the SCORE risk tables were applied. The 2003 SCORE calculator was recently updated to a new prediction model: SCORE2. This new algorithm improves the identification of individuals from the general population at high risk of developing CVD in Europe. Our objective was to compare the predictive capacity between the original SCORE and the new SCORE2 to identify RA patients with subclinical atherosclerosis and, consequently, high risk of CVD. 1168 non-diabetic patients with RA and age > 40 years were recruited. Subclinical atherosclerosis was searched for by carotid ultrasound. The presence of carotid plaque and the carotid intima media wall thickness (cIMT) were evaluated. SCORE and SCORE2 were also calculated. The relationships of SCORE and SCORE2 to each other and to the presence of subclinical carotid atherosclerosis were studied. The correlation between SCORE and SCORE2 was found to be high in patients with RA (Spearman’s Rho = 0.961, p < 0.001). Both SCORE (Spearman’s Rho = 0.524) and SCORE2 (Spearman’s Rho = 0.521) were similarly correlated with cIMT (p = 0.92). Likewise, both calculators showed significant and comparable discriminations for the presence of carotid plaque: SCORE AUC 0.781 (95%CI 0.755–0.807) and SCORE2 AUC 0.774 (95%CI 0.748–0.801). Using SCORE, 80% and 20% of the patients were in the low or moderate and high or very high CVD risk categories, respectively. However, when the same categories were evaluated using SCORE2, the percentages were different (58% and 42%, respectively). Consequently, the number of RA patients included in the high or very high CVD risk categories was significantly higher with SCORE2 compared to the original SCORE. (p < 0.001). In conclusion, although predictive capacity for the presence of carotid plaque is equivalent between SCORE and SCORE2, SCORE2 identifies a significantly higher proportion of patients with RA who are at high or very high risk of CVD.
Development of a Machine Learning Model to Distinguish between Ulcerative Colitis and Crohn’s Disease Using RNA Sequencing Data
Authors: Park Soo-Kyung , Kim Sangsoo , Lee Gi-Young , Kim Sung-Yoon , Kim Wan , Lee Chil-Woo , Park Jong-Lyul , Choi Chang-Hwan , Kang Sang-Bum , Kim Tae-Oh , Bang Ki-Bae , Chun Jaeyoung , Cha Jae-Myung , Im Jong-Pil , Ahn Kwang-Sung , Kim Seon-Young , Park Dong-Il
Published: December 2021

Crohn’s disease (CD) and ulcerative colitis (UC) can be difficult to differentiate. As differential diagnosis is important in establishing a long-term treatment plan for patients, we aimed to develop a machine learning model for the differential diagnosis of the two diseases using RNA sequencing (RNA-seq) data from endoscopic biopsy tissue from patients with inflammatory bowel disease (n = 127; CD, 94; UC, 33). Biopsy samples were taken from inflammatory lesions or normal tissues. The RNA-seq dataset was processed via mapping to the human reference genome (GRCh38) and quantifying the corresponding gene models that comprised 19,596 protein-coding genes. An unsupervised learning model showed distinct clusters of four classes: CD inflammatory, CD normal, UC inflammatory, and UC normal. A supervised learning model based on partial least squares discriminant analysis was able to distinguish inflammatory CD from inflammatory UC after pruning the strong classifiers of normal CD vs. normal UC. The error rate was minimal and affected only two components: 20 and 50 genes for the first and second components, respectively. The corresponding overall error rate was 0.147. RNA-seq analysis of tissue and the two components revealed in this study may be helpful for distinguishing CD from UC.
Minimum Query Set for Decision Tree Construction
Authors: Wieczorek Wojciech , Kozak Jan , Strąk Łukasz , Nowakowski Arkadiusz
Published: December 2021

A new two-stage method for the construction of a decision tree is developed. The first stage is based on the definition of a minimum query set, which is the smallest set of attribute-value pairs for which any two objects can be distinguished. To obtain this set, an appropriate linear programming model is proposed. The queries from this set are building blocks of the second stage in which we try to find an optimal decision tree using a genetic algorithm. In a series of experiments, we show that for some databases, our approach should be considered as an alternative method to classical ones (CART, C4.5) and other heuristic approaches in terms of classification quality.
Measuring the Post-Impact of Programming MOOCs: Development and Validation of an Instrument
Authors: Säde Merilin , Suviste Reelika , Luik Piret
Published: December 2021

Massive open online courses (MOOCs) can potentially affect the lives of millions of people, but there is little research on how a programming MOOC could affect participants’ lives after participation. In Estonia, we have organised several programming MOOCs over the years, attended by over 14,000 people. This inspired us to develop and validate a scale for measuring the impact of programming MOOC on participants’ lives. We analysed data from 1261 MOOC participants who had completed at least one of our programming MOOCs. Confirmatory factor analysis (CFA) was used to validate the developed scale. The final model fitted quite well to the data. We found that the factors that influence learners’ lives after a MOOC include acquired learning skills, interest in continuing computer science related studies, learning experience gained from the MOOC, the MOOC’s impact on work and personal life, and new contacts that are established with other participants and organisers. We also compared the means of the factors. The highest-rated factor was related to the learning experience from the MOOC and the lowest-rated was related to finding new contacts through the MOOC.
Perezhivanie and Its Application within Early Childhood Science Education Research
Authors: Christodoulakis Nikolaos , Vidal Carulla Clara , Adbo Karina
Published: December 2021

Perezhivanie is a concept that was originally defined by Vygotsky, but it did not become a part of educational theory until recently. Today the concept has been revived, and it is now used as a way to include emotional aspects into education and educational research. The concept also provides a rationale for describing and forming personalised learning. The present study provides a literature review with the aim of covering the variety in definitions of the concept, as well as the different perspectives that the concept lends to research in general, and to research with focus on early years education in particular. Results show that the concept has been applied within the most common theoretical perspectives in use today (such as social, cultural and subjective perspectives) with an interesting array of outcomes, such as design of educational methods, analysis of different modes of experiencing and development of self-awareness. The use of this concept becomes a shift toward more emotional perspectives of learning and development that may not be altogether positive, as perezhivanie holds the risk of blurring the border between psychotherapy and education, which is something that would provide new challenges for education in general and especially for teacher education.
Characteristics and Genetic Mechanism of Pore Throat Structure of Shale Oil Reservoir in Saline Lake—A Case Study of Shale Oil of the Lucaogou Formation in Jimsar Sag, Junggar Basin
Authors: Zha Xiaojun , Lai Fuqiang , Gao Xuanbo , Gao Yang , Jiang Nan , Luo Long , Li Yingyan , Wang Jia , Peng Shouchang , Luo Xun , Tan Xianfeng
Published: December 2021

The shale oil reservoir of the Lucaogou Formation in the Jimsar Sag has undergone tectonic movement, regional deposition and complex diagenesis processes. Therefore, various reservoir space types and complex combination patterns of pores have developed, resulting in an intricate pore throat structure. The complex pore throat structure brings great challenges to the classification and evaluation of reservoirs and the efficient development of shale oil. The methods of scanning electron microscopy, high-pressure mercury injection, low-temperature adsorption experiments and thin-slice analysis were used in this study. Mineral, petrology, pore throat structure and evolution process characteristics of the shale oil reservoir were analyzed and discussed qualitatively and quantitatively. Based on these studies, the evolution characteristics and formation mechanisms of different pore throat structures were revealed, and four progressions were made. The reservoir space of the Lucaogou Formation is mainly composed of residual intergranular pores, dissolved pores, intercrystalline pores and fractures. Four types of pore throat structures in the shale oil reservoir of the Lucaogou Formation were quantitatively characterized. Furthermore, the primary pore throat structure was controlled by a sedimentary environment. The pores and throats were reduced and blocked by compaction and cementation, which deteriorates the physical properties of the reservoirs. However, the dissolution of early carbonate, feldspar and tuffaceous minerals and a small amount of carbonate cements by organic acids are the key factors to improve the pore throat structure of the reservoirs. The genetic evolution model of pore throat structures in the shale oil reservoir of the Lucaogou Formation are divided into two types. The large-pore medium-fine throat and medium-pore medium-throat reservoirs are mainly located in the delta front-shallow lake facies and are characterized by the diagenetic assemblage types of weak compaction–weak carbonate cementation–strong dissolution, early medium compaction–medium calcite and dolomite cementation–weak dissolution. The medium-pore fine throats and fine-pore fine throats are mainly developed in shallow lakes and semi-deep lakes. They are characterized by the diagenetic assemblage type of strong compaction–strong calcite cementation–weak dissolution diagenesis. This study provides a comprehensive understanding of the pore throat structure and the genetic mechanism of a complex shale oil reservoir and benefits the exploration and development of shale oil.
A Review on Optimal Control for the Smart Grid Electrical Substation Enhancing Transition Stability
Authors: Pavon Wilson , Inga Esteban , Simani Silvio , Nonato Maddalena
Published: December 2021

This paper is a research article for finding the optimal control of smart power substations for improving the network parameters and reliability. The included papers are the most essential and main studies in the field, which propose a different approach to reach the best performance in electrical power systems. The parameters for improvement are the ability for tracking of the reference signal, stabilizing the system, reducing the error in steady state and controlling the behavior in transient state. The research focuses with the reaching a better transient stability considering voltage and frequency dynamic parameters. The optimal model for the control is focused on minimizing energy consumption but maintaining the controllable parameters, exploring some optimization techniques to find the optimal control, with of aim of minimizing the response time, the energy consumption, and maximizing the reliability by means of improving the controller to be more robust.
Surrogate Models Applied to Optimized Organic Rankine Cycles
Authors: Vilasboas Icaro Figueiredo , dos Santos Victor Gabriel Sousa Fagundes , Ribeiro Armando Sá , da Silva Julio Augusto Mendes
Published: December 2021

Global optimization of industrial plant configurations using organic Rankine cycles (ORC) to recover heat is becoming attractive nowadays. This kind of optimization requires structural and parametric decisions to be made; the number of variables is usually high, and some of them generate disruptive responses. Surrogate models can be developed to replace the main components of the complex models reducing the computational requirements. This paper aims to create, evaluate, and compare surrogates built to replace a complex thermodynamic-economic code used to indicate the specific cost (US$/kWe) and efficiency of optimized ORCs. The ORCs are optimized under different heat sources conditions in respect to their operational state, configuration, working fluid and thermal fluid, aiming at a minimal specific cost. The costs of 1449.05, 1045.24, and 638.80 US$/kWe and energy efficiencies of 11.1%, 10.9%, and 10.4% were found for 100, 1000, and 50,000 kWt of heat transfer rate at average temperature of 345 °C. The R-square varied from 0.96 to 0.99 while the number of results with error lower than 5% varied from 88% to 75% depending on the surrogate model (random forest or polynomial regression) and output (specific cost or efficiency). The computational time was reduced in more than 99.9% for all surrogates indicated.
Biological Consequences of Marine Energy Development on Marine Animals
Authors: Hemery Lenaïg G. , Copping Andrea E. , Overhus Dorian M.
Published: December 2021

Marine energy devices harness power from attributes of ocean water to form a sustainable energy source. Knowledge gaps remain about whether marine energy systems can affect the environment, adding another threat to animal populations and habitats already under pressure from climate change and anthropogenic activities. To date, potential environmental effects have been studied under the scope of stressor–receptor interactions, where moving parts of, or emissions from, a system could harm the animals, habitats, and natural processes. While crucial for understanding effects and identifying knowledge gaps, this approach misses a holistic view of what animals may experience in the presence of marine energy systems. We look at six biological consequences and forces that drive the health of an animal population and the effects expected from marine energy development: success of early life stages; changes in competitive capabilities; growth and survival based on food availability; susceptibility to predators; injury or death; and reproductive success. We use case studies to develop this approach, focusing on a variety of marine animals. An approximate level of risk is assigned for each interaction based on the biological consequences. This work highlights the need to examine the effects of marine energy development on animal populations within their natural habitats.
The Feasibility of Using Zero-Emission Electric Boats to Enhance the Techno-Economic Performance of an Ocean-Energy-Supported Coastal Hotel Building
Authors: Guo Xinman , Cao Sunliang , Xu Yang , Zhu Xiaolin
Published: December 2021

The topics of zero-emission/energy buildings and electric mobility are increasingly being discussed as solutions to alleviate the environmental burden caused by energy consumption and CO2 emissions in both sectors. This study investigates a zero-energy hotel building supported by a hybrid ocean renewable energy system, which interacts with several zero-emission electric boats. Nine different combinations of floating photovoltaics (FPV) and wave energy converters (WEC) are investigated to compensate for their different fluctuations and the stochasticity of energy generation. Using TRNSYS 18 to perform modeling and simulation, a comprehensive techno-economic-environmental analysis of the hybrid system was conducted. The results indicate that when the total annual generation ratios of WEC and FPV are 76% and 24%, respectively, this combination can achieve the best energy weighted matching index (WMI). The WMI reached its maximum (0.703) when 16 boats were sailing at 15 km/h for a distance of 7.5 km. However, increasing the number of boats to 16 does not help improve economic returns or reduce the annual operational equivalent CO2 emission factor of the hybrid system. Depending on the maximum number of electric boats designed for this study, the non-dominated WMI would be limited to 0.654.
Evolution of Hydropower Support Schemes in Poland and Their Assessment Using the LCOE Method
Authors: Godyń Izabela , Dubel Anna
Published: December 2021

Hydropower as stable power installations play an important role among renewable energy sources. Yet, their share in renewable energy is small. Currently, it is only 10% of energy from renewable energy sources (RES), compared to 27% in 2010. Therefore, the aim of this paper is to assess the RES support schemes in Poland related to hydropower, such as green certificates, auctions and FIT, with the use of the Levelized Cost of Electricity (LCOE) analysis in order to determine which support scheme is best incentivizing hydropower development. The evolution of the hydropower support scheme in Poland is presented. The total LCOE and possible revenues from support systems for various segments of hydropower installations are graphically analyzed for two analysis periods (15 and 50 years) and for two discount rates (7% and 11.4%). The analysis shows the great importance of the support schemes in the profitability of the hydropower plants investments. The LCOE graphical analysis proves to be suitable for showing sensitivity analysis of capital and operating costs of various sizes of hydropower plants. The analysis shows that the LCOE in micro-power plants is usually higher than the support and revenues available in the green certificates or auctions or FIT schemes in Poland.
Highlighting Complex Long-Term Succession Pathways in Mixed Forests of the Pacific Northwest: A Markov Chain Modelling Approach
Authors: Blanco Juan A. , Lo Yueh-Hsin , Kimmins James P. , Weber Adrian
Published: December 2021

Forest succession is an ecological phenomenon that can span centuries. Although the concept of succession was originally formulated as a deterministic sequence of different plant communities by F. Clements more than a century ago, nowadays it is recognized that stochastic events and disturbances play a pivotal role in forest succession. In spite of that, forest maps and management plans around the world are developed and focused on a unique “climax” community, likely due to the difficulty of quantifying alternative succession pathways. In this research, we explored the possibility of developing a Markov Chain model to study multiple pathway succession scenarios in mixed forests of western red cedar, hemlock and Pacific silver fir on northern Vancouver Island (western Canada). We created a transition matrix using the probabilities of change between alternative ecological stages as well as red cedar regeneration. Each ecological state was defined by the dominant tree species and ages. Our results indicate that, compared to the traditional Clementsian, deterministic one-pathway succession model, which is unable to replicate current stand distribution of these forests in the region, a three-pathway stochastic succession model, calibrated by a panel of experts, can mimic the observed landscape distribution among different stand types before commercial logging started in the region. We conclude that, while knowing the difficulty of parameterizing this type of models, their use is needed to recognize that for a given site, there may be multiple “climax” communities and hence forest management should account for them.
Effect of GNPs on the Piezoresistive, Electrical and Mechanical Properties of PHA and PLA Films
Authors: Mármol Gonzalo , Sanivada Usha Kiran , Fangueiro Raul
Published: December 2021

Sustainability has become the primary focus for researchers lately. Biopolymers such as polyhydroxyalkanoate (PHA) and polylactic acid (PLA) are biocompatible and biodegradable. Introducing piezoresistive response in the films produced by PLA and PHA by adding nanoparticles can be interesting. Hence, a study was performed to evaluate the mechanical, electrical and piezoresistive response of films made from PHA and PLA. The films were produced by solvent casting, and they were reinforced with graphene nanoplatelets (GNPs) at different nanoparticle concentrations (from 0.15 to 15 wt.%). Moreover, cellulose nanocrystals (CNC) as reinforcing elements and polyethylene glycol (PEG) as plasticizers were added. After the assessment of the nanoparticle distribution, the films were subjected to tests such as tensile, electrical conductivity and piezoresistive response. The dispersion was found to be good in PLA films and there exist some agglomerations in PHA films. The results suggested that the incorporation of GNPs enhanced the mechanical properties until 0.75 wt.% and they reduced thereon. The addition of 1% CNCs and 20% PEG in 15 wt.% GNPs’ tensile values deteriorated further. The PHA films showed better electrical conductivity compared to the PLA films for the same GNPs wt.%. Gauge factor (GF) values of 6.30 and 4.31 were obtained for PHA and PLA, respectively.
Development Environments and Factors of Subsidence Dolines
Authors: Veress Márton
Published: December 2021

This study describes the development environments of subsidence dolines based on literary data (development environments create favorable conditions for the local denudation of superficial deposit and thus, for the development of depressions). Development environments are the inclination of the bearing surface, the secondary porosity of the bedrock, the characteristics of the cover, water influx into the cover, karstwater and groundwater, melting permafrost, and anthropogenic activity. These may become optimal when controlled by various geological, geomorphological, and climatic factors. Development environments may be qualitative (there is doline development in case of its presence) and quantitative (doline development occurs in case of suitable quantitative values). The development environment groups of subsidence dolines are environment groups independent of water level, environment groups dependent on water level, and anthropogenic environment groups. In the case of an environment group independent of water level, surface morphology, cover characteristics, geomorphic evolution, and water supply are determining, while in case of an environment group dependent of water level, subsurface water level and its fluctuations and the characteristics of rainfalls interrupting dry seasons are crucial. Anthropogenic impacts mainly affect doline development through water balance.
Pathways Linking Health Literacy to Self-Management in People with Type 2 Diabetes
Authors: Lee Eun-Hyun , Lee Young Whee , Chae Duckhee , Lee Kwan-Woo , Hong Seongbin , Kim So Hun , Chung Jin Ook
Published: December 2021

Health literacy is considered to be an emerging determinant of health behaviors and outcomes. The underlying mechanisms linking health literacy to diabetes self-management are currently unclear. This study assessed a mediation model consisting of a direct pathway between health literacy and self-management, and indirect pathways via social isolation only, self-efficacy only, and social isolation and self-efficacy serially in people with type 2 diabetes. A cross-sectional design was employed, and a total of 524 participants were recruited from outpatient clinics of multi-institutions from June 2020 to February 2021. The mediation model was analyzed using the PROCESS macro on SPSS with bootstrap bias-corrected 95% confidence intervals (CIs) with 10,000 bootstrapping iterations. Health literacy positively affected self-management. The estimated indirect effect of health literacy on self-management via social isolation was significant, at 0.018 (95% CI = 0.004–0.036). The indirect effect via self-efficacy was estimated at 0.214 (95% CI = 0.165–0.266). The indirect effect via social isolation and self-efficacy serially was 0.013 (95% CI = 0.006–0.023). The findings of this study suggest that clinical practice can be improved through more comprehensive diabetes self-management interventions that promote all of the components of health literacy, social contacts/networks, and self-efficacy in particular.