bluuebunny/crossref_metadata_2025 huggingface dataset:
A customer perspective on infrastructure & legislative effects to use mobile banking app in Nigeria
Authors: Hassan Abba , Yakubu Mohammed Bala , Bulama Mohammed , Shitu Aliyu Abdullahi
Published: March 2019

In today’s age of new opportunities and emerging technologies, various studies have affirmed that the adoption of information and communication technology required an enabling environment like that of mobile device. Mobile banking is an ICT application considered to be of vital use among people in different countries of the world, who are likely to have different infrastructural development or resource facilitating conditions. Despite all the benefits of mobile banking application, yet its adoption is beyond the industry expectations in Nigeria and most African countries. This can be attributed to some factors. This study examines the resistance factors that influence the adoption of mobile banking application in Nigeria in relation to enabling environment, based on customers perspective and concluded that customer’s resistance to use mobile banking services in Nigeria was significantly influenced by inadequate bank branches, absence of legislative framework, high cost of monthly Internet subscription and poor quality of Internet/telecommunication services.
 
Keywords: Mobile banking usage, customer’s, technology, resistance, resources.
Cálculo de la línea base de las emisiones de gases de efecto invernadero y proyecciones a futuro para el sector transporte en el estado de Veracruz, México
Authors: Martínez-Rodríguez María Concepción , Campos- Villegas Lorena Elizabeth , Castillo-Monroy José Jesús
Published: March 2019

El transporte en el Estado de Veracruz-México, representa el tercer sector en el consumo de energía y el de mayor crecimiento en emisiones de Gases Efecto Invernadero (GEI), el cálculo de la línea base o escenario tendencial mediante el modelo Long-range Energy Alternatives Planning system (LEAP) en el periodo 2010-2026 reporta un rango de 10.3 millones de TonCO2e a 15.3 millones de TonCO2e respectivamente, derivado de los consumos de gasolina y diésel principalmente. Los escenarios planteados se relacionan con la penetración de vehículos a diésel, así como de vehículos híbridos, uso de etanol como combustible y disminución del uso de automóvil particular como los camiones para pasajeros y camiones para carga. El impulso de estos escenarios tiene el potencial de reducir las emisiones de combustibles para el año 2026 en una cantidad equivalente a más del 15% del total de emisiones durante el periodo 2010-2026.
BISNIS JASA PENYALUR TENAGA KERJA PERSPEKTIF HUKUM EKONOMI SYARIAH
Authors: Abdurohman Dede
Published: March 2019

Working is an attached part of life series. In Indonesia, some people try to be employed through labor distributor services, known as outsourcing. Indonesian law confirms that Outsourcing activities are protected by the act No. 13 of 2003 concerning Manpower, Decree of the Minister of Manpower and Transmigration of the Republic of Indonesia Number: KEP.101/MEN/VI/2004 concerning Procedures for Licensing of Workers/Labor Service Providers. However, workers joining Outsourcing agent considered themselves unprosperous. They then choose demonstration as a way to express their aspiration. The phenomenon of demonstration of labor in Indonesia usually can be seen every year in May. The issue is usually about the minimum wage which is according to them under the welfare standard and another is about outsourcing abolishment. In this article, the author will focus on Outsourcing agent, its system in Indonesia according to Islamic Economic Law’s perspective? The author thinks it is important to discuss since the labors do the demonstration every year for the same demands. Based descriptif kwalitatif analysis in Islamic business law, the outsourcing company is halal. Goverment can up the minimum wage consider the maslahah.

Bekerja merupakan bagian tak terpisah dari rangkaian kehidupan. Di Indonesia, beberapa orang memilih mencari pekerjaan melalui agen penyalur tenaga kerja atau yang disebut outsourcing. Hukum di Indonesia menegaskan bahwa kegiatan outsourcing dilindungi oleh Undang-Undang No. 13 Tahun 2003 tentang Ketenagakerjaan, Keputusan Menteri Tenaga Kerja dan Transmigrasi Republik Indonesia No.: KEP.101/MEN/VI/2004 tentang Tata Cara Perijinan Perusahaan Penyedia Jasa Pekerja/Buruh. Namun, buruh yang terjaring dalam lembaga outsourcing menganggap diri mereka belum sejahtera. Karenanya, mereka memilih demonstrasi untuk mengungkapkan aspirasinya. Fenomena demonstrasi para pekerja di Indonesia dapat disaksikan setiap tahunnya pada bulan Mei. Tuntutan mereka biasanya seputar upah minimum yang menurut mereka di bawah standar kesejahteraan dan penghapusan sistem outsourcing. Dalam artikel ini, penulis fokus pada lembaga outsourcing dan sistemnya di Indonesia menurut perspektif Hukum Ekonomi Syariah. Berdasarkan analisis deskriptif kwalitatif, maka perusahaan outsourcing sah secara hukum dan halal menurut hukum ekonomi syariah. Pemerintah dapat menaikkan upah minimum dengan memperhatikan kemaslahatan.
THE PROBLEMATICS OF EXECUTION LAW AGAINST NON-EXECUTABLE JUDGMENTS AND COMPARISONS WITH MALAYSIAN LAW
Authors: Ariadi Subagyono Bambang Sugeng , Anand Ghansham
Published: March 2019

In public courts, the litigation of civil case is under civil law procedure. This is a legal regulation to maintain material civil laws. The procedural law is also a way to file a particular civil case to civil court and to organize judges’ ways in making judgment toward legal subject. Civil law procedure prevents any vigilante actions that creates public legal order. Judiciaries provide protection for legal subject in preserving their rights and prevent any arbitrary actions. After case investigation process set under procedural law, a court judgment is made to judge and solve case. Legal actions are subsequently conducted to reach fixed legal judgment (inkracht van gewijsde). Some executions for civil cases in Indonesia is suspended since the object is different from reality or non-executable. Furthermore, civil case judgment is sometimes contradictory to criminal cases, although the objects are similar. Either litigant and/or defendant files request to the Supreme Court to have a legal protection or the chairman of district court requests for an instruction from the Supreme Court, may suspend court judgment. Therefore, the implementation of court judgments with legal power is still undeniably problematic. If the execution is suspended or not allowed, it may disadvantage “the justice seekers”; public society. The suspended or non-executable judgment should be immediately addressed on its implementation, instead of its law.

Di pengadilan umum, proses kasus perdata berada dalam prosedur hukum perdata. Ini adalah peraturan hukum untuk mempertahankan hukum sipil material. Undang-Undang prosedural ialah cara mengajukan kasus perdata ke pengadilan sipil dan mengatur cara hakim memutuskan subjek hukum. Prosedur hukum perdata bertujuan mencegah tindakan hakim-sendiri sehingga tercipta tatanan hukum publik. Peradilan memberikan perlindungan bagi subjek hukum dalam melestarikan haknya dan mencegah kesewenang-wenangan. Setelah proses penyelidikan kasus sebagaimana diatur dalam hukum prosedural, putusan pengadilan dibuat untuk menilai dan memecahkan kasus. Tindakan hukum selanjutnya dilakukan hingga mendapat keputusan hukum tetap (inkracht van gewijsde). Beberapa putusan kasus perdata Indonesia ditangguhkan karena objek berbeda dari kenyataan atau tidak dapat dieksekusi. Selanjutnya, putusan kasus perdata terkadang bertentangan dengan kasus pidana, meskipun objeknya sama. Baik penggugat dan/atau terdakwa mengajukan permintaan ke Mahkamah Agung untuk memiliki perlindungan hukum atau ketua dari pengadilan distrik meminta instruksi dari Mahkamah Agung, bisa menangguhkan keputusan pengadilan. Karenanya, pelaksanaan putusan pengadilan dengan kekuatan hukum masih bermasalah. Jika eksekusi ditangguhkan atau tidak diizinkan, tentu dapat merugikan “para pencari keadilan”; masyarakat umum. Putusan yang ditangguhkan atau tidak dapat dieksekusi harus segera ditangani pada pelaksanaannya, bukan hukumnya.
KEMASLAHATAN DALAM PERLINDUNGAN HUKUM TERHADAP KONSUMEN DAN PELAKU USAHA MELALUI MEKANISME PENETAPAN HARGA OLEH NEGARA
Authors: Munthe Mhd Erwin
Published: March 2019

In business competition there are often monopolistic activities which result in high prices for the game of business actors. This makes consumers uneasy because they do not get varied prices and fair prices, while for small business actors they do not have competitive ability. The existence of monopolistic practices and unfair competition is not in line with the constitution. Because the 1945 Constitution mandates that the national economy must be carried out by promoting people’s welfare. Therefore, the presence of the government is very necessary to realize the ideals mandated by the constitution and legislation. This study aims to analyze the mechanism and criteria for pricing by the state. The result is providing legal protection to consumers and other business actors, the government sets the highest retail price and the lowest retail price and provides subsidies to imported products that control the livelihoods of many people. This effort is carried out to realize mutual benefit between producers and consumers.

Dalam persaingan usaha sering terdapat kegiatan-kegiatan monopoli yang mengakibatkan tingginya harga atas permainan pelaku usaha. Hal ini membuat kegelisahan konsumen karena tidak mendapatkan harga yang variatif dan wajar, sedangkan bagi pelaku usaha kecil tidak memiliki kemampuan bersaing. Adanya praktik monopoli dan persaingan tidak sehat ini tidaklah sejalan dengan konstitusi. Karena UUD 1945 mengamanatkan bahwa perekonomian nasional harus dijalankan dengan mengedepankan kesejahteraan rakyat. Oleh karenanya, kehadiran pemerintah sangat diperlukan untuk mewujudkan cita-cita yang diamanatkan konstitusi dan peraturan perUndang-Undangan. Penelitian ini bertujuan untuk menganalisis mekanisme dan kriteria penetapan harga oleh negara. Sementara metodenya penelitian doktrinal dalam bentuk penelitian evaluatif. Pendekatan yang digunakan adalah pendekatan perUndang-Undangan. Hasil penelitian ini adalah bahwa dalam memberikan perlindungan hukum kepada konsumen dan pelaku usaha lainnya, pemerintah menetapkan harga eceran tertinggi dan harga eceran terendah serta memberikan subsidi pada produk-produk impor yang menguasai hajat hidup orang banyak. Upaya ini dilakukan untuk mewujudkan kemaslahatan bersama antara produsen dan konsumen.
Breastfeeding Intention Versus Outcomes at Two to Three Weeks Postpartum
Authors: Rouse Miranda , Ferrarello Debi Page
Published: March 2019

Breastfeeding is the optimal nutrition for infants, offering protection from many illnesses for both infant and mother. While breastfeeding initiation rates approach or exceed Healthy People 2020 goals, increasing duration remains a national public health priority. Hospital practices play an important role. An urban, academic hospital in the northeast United States with Baby-Friendly designation initiated a quality improvement (QI) project to learn how infant feeding outcomes at 2–3 weeks postpartum compare to initial breastfeeding intention. A lactation student made telephone calls to a convenience sample of breastfeeding mothers, questioning them about their current infant feeding practices and the breastfeeding support they received. The women participating in this QI project were those deemed most likely to meet their infant feeding goals. All the women gave birth in a Baby-Friendly facility, thus all their nurses had at least 20 hours of breastfeeding education, all medical providers had had at least 3 hours of breastfeeding education, and IBCLCs were available to inpatients 7 days a week. All were encouraged to call the hospital's Breastfeeding Warmline and were provided with a list of outpatient resources. However, just2–3 weeks postpartum, one-third were not exclusively breastfeeding despite their initial intention.
Impact of enological tannins on laccase activity
Authors: Vignault Adeline , Pascual Olga , Jourdes Michael , Moine Virginie , Fermaud Marc , Roudet Jean , Canals Joan Miquel , Teissedre Pierre-Louis , Zamora Fernando
Published: March 2019

Aims: The aim of this research was to determine and quantify the ability of enological tannins to reduce laccase activity and, consequently, to protect wine color against enzymatic browning and/or oxidasic haze.Methods and results: Botrytized grape juice with laccase activity was obtained by inoculating Botrytis cinerea in healthy mature grapes. Laccase activity was determined in grape juice before and after supplementation with enological tannins using the syringaldazine method. White micro-fermentations were performed in the presence or not of laccase activity and supplemented or not with enological tannins in order to determine how the color was affected. Similarly, red micro-fermentations were performed using white grape juice supplemented with malvidin-3-O-glucoside. All enological tannins inhibited laccase activity and protected the wine color.Conclusion: Supplementation with enological tannins is an interesting tool to inhibit laccase activity and protect the color of white wines from browning and the color of red wines from oxidasic haze.Significance and impact of the study: This is the first scientific study evidencing the inhibitory effect of enological tannins on laccase activity in winemaking conditions.
PATENT RIGHT TRANSFER THROUGH WAQF: WHAT ARE THE REQUIREMENTS?
Authors: Praja Chrisna Bagus Edhita , Mulyadi Mulyadi , Riswandi Budi Agus , Arifah Kuni Nasihatun
Published: March 2019

This study aims to examine and identify criteria for patents that can be used as waqf assets. Patents are very potential as waqf asset because of a large number of patent holders in Indonesia with the requirements of productive waqf. Patents are a type of Intellectual Property with the provision of a specified period and are still a debate related to the period of waqf which is always a pro and contradiction, some scholars consider waqf property to be forever but in the waqf law is allowed a waqf property with a specified period. This research method uses a normative legal research method with a Law approach and concept approach as well as secondary data review. The Act used is the Patent Law and the Waqf Act. The results show that the patent that can be used as an waqf asset refers to the provision of waqf property which includes (1) legal ownership of the patent owner and evidenced by a patent certificate (2) is not controversial which means not in a legal dispute until in Kracht van gewijsde or not in internal conflicts for patents owned by several inventors (3) have economic value and use value so that it can benefit the community. Patents can be used as an waqf asset because in the Waqf Law it is explained that the waqf property may be for a specified period. The period in the patent waqf in the deed of the waqf pledge must be adjusted to the period of patent protection.
THE INSURANCE OF LIABILITY AS AN ATTEMPT OF RISK TRANSFERING OVER THE LOSS CAUSED BY NOTARY PULIC AND LAND DEED OFFICIALS
Authors: Anand Ghansham , Hernoko Agus Yudha , Huda Mokhamad Khoirul
Published: March 2019

This study primarily aimed to identify the type of insurance of liabilities as an attempt of risk transferring over the loss caused by the notary public and land deed officials. The method of this study was juridical-normative. The result showed that the notary public and land deed officials (PPAT) were both public officials authorized to establish an authentic deed due to clients’ requests. Any violation or negligence by Notary public and land deed officials that was out of the track of legal law might lead the clients into a disadvantageous situation. Such violation or negligence made the established deed null and void, void-able, or even turned into an private deed. This brought an effect to the client as the injured party, and thus, they might file a lawsuit in case of suing for compensation, indemnification, and interest through court proceeding.  Therefore, it needed an agency of risk-transfering in the form of insurance. The insurance of professional liability is a product of public insurance taking-over a risk that is supposed to be charged by the Notary Public and Land Deed Officials. The object of this insurance refers to the insurer’s obligation to pay compensation over particular loss the client has suffered and other expenses due to the risk.
Implementasi Proses Alih Media Pada Koleksi Langka/Kuno Balai Layanan Perpustakaan Ghratama Pustaka Yogyakarta
Authors: Nurillita Fella Rizka
Published: March 2019

Tulisan ini bertujuan untuk mengkaji implementasi proses alih media pada koleksi langka/ kuno Balai Layanan Perpustakaan Ghratama Pustaka Yogyakarta. Seiring berkembangnya kemajuan teknologi yang pesat akan membawa kemudahan pada kehidupan masyarakat dalam memenuhi kebutuhan informasi. Salah satunya tentu pemanfaatan produk digital sehingga mendorong dan memberikan inovasi pada koleksi langka/ kuno Balai Layanan Perpustakaan Ghratama Pustaka Yogyakarta untuk di alih mediakan. Dengan pemahaman bahwa proses alih media merupakan proses teknologi guna melestarikan khasanah bangsa dan melestarikan nilai informasi yang terkandung dalam bahan pustaka. Koleksi kuno/ langka merupakan koleksi yang berupa naskah asli tulisan tangan tentang kebudayaan maupun cerita yang bertuliskan huruf Indonesia, huruf Jawa kuno, maupun tulisan bahasa asing seperti bahasa Belanda. Koleksi kuno/ langka bertemakan kesehatan, arsip pemerintah, catatan perjuangan sebelum maupun sesudah kemerdekaan. Salah satu indikator proses alih media adalah dokumen bentuk fisik (kertas) menjadi bentuk elektronik untuk kemudian dapat dikelola menggunakan teknologi untuk kemudian dapat dikelola menggunakan teknologi informasi.
Oil price and Indonesian economic growth
Authors: Sultan  , Jhonny Sarungu Julius , Maqnus Soesilo Albertus , Aisyah Tri Rahayu Siti
Published: March 2019

Oil prices and economic growth are important indicators to see the success of Indonesia’s development performance. The use of oil as the world’s main energy source in general and Indonesia in particular is driven by industrialization. The more industries, the greater the energy resources needed. In the same context, economic growth will also increase oil demand. The purpose of this study is to examine and create empirical evidence of the relationship between world oil prices and economic growth towards domestic oil prices. Furthermore, to test and create empirical evidence on the relationship of domestic oil prices, agriculture, trade, investment, inflation, interest rates, industry, labor, exchange rates and balance of payments to economic growth. The expected output of this research will be to provide information on the policy of the transmission mechanism of oil prices and economic growth in Indonesia. The method used is descriptive and econometric approach to the analysis of simultaneous equation models with two stages of the least squares method. The results of the study indicate that there is a simultaneous relationship between oil prices and economic growth. Economic growth, world oil prices and domestic oil prices a year ago had a positive effect on domestic oil prices. The second result shows that domestic oil, agriculture, investment, interest rates, industry, exchange rates, balance of payments and economic growth in the previous year have a positive effect on economic growth, while trade, inflation and labor have a negative influence on economic growth.
Features of prenatal diagnostics of trisomy 9 in the first trimester
of pregnancy
Authors: E.I. Golovataya, I.V. Novikova
Published: March 2019

We report about 4 cases of prenatal diagnostics of mosaic trisomy 9 in the first trimester of pregnancy.
The data of ultrasound, cytogenetic and pathoanatomical studies are presented. Prenatal diagnosis of trisomy
9 is difficult due to the non-specificity of the anomalies characteristic of it. Trisomy 9 in complete or mosaic
form in chorionic villus cells may not be confirmed in the fetal tissues. Interpreting the results of cytogenetic
analysis of chorionic villus cells and deciding on the prognosis of pregnancy with trisomy 9, the whole complex of clinical data should be taken into account: the results of the ultrasound examination and additional
cytogenetic studies, anamnesis
A retrospective analysis of prenatal diagnosis of transposition
of the great arteries in the Republic of Сrimea
Authors: O.N. Kostritsova, G.E. Sukhareva, I.N. Imnadze
Published: March 2019

A retrospective analysis of 24 cases prenatal diagnosed of the transposition of great arteries and examined its postnatal outcomes. The analysis of diagnostic errors is carried out and the effectiveness of prenatal
diagnosis of the transposition of great arteries in the Republic of Crimea for 2011–2016 is presented.
Real possibilities of prenatal diagnosis of translocation form
Down’s syndrome
Authors: O.L. Galkina, E.V. Vlasenko, N.B. Shmakova, O.V. Sahar
Published: March 2019

Objective: analyses of real possibilities of prenatal diagnosis of translocation form Down’s syndrome.
Materials: 243 cases of Down's syndrome were diagnosed within 15 years, translocation variant of trisomy
21 was found in 5 cases (2 %). The article provides the analyses of the results of prenatal examination of the
fetuses with the translocation form of Down's syndrome.
Results: in all 5 cases abnormal biochemical screening and ultrasound markers of chromosomal abnormalities were recorded. Prenatal karyotyping was carried out in one observation. In 4 cases cytogenetic
diagnosis was performed postnatally. The perinatal outcome is known in all the observations.
Conclusion: Prenatal diagnosis of the translocation form of Down's syndrome is possible in most cases,
provided that the screening time of the examination of pregnant women is met and the indications for an
expert ultrasound evaluation of the fetus using the latest technology are broadened
Adsorptive treatment via simultaneous removal of copper, lead and zinc from soil washing wastewater using spent coffee grounds
Authors: Futalan Cybelle M. , Kim Jongsik , Yee Jurng-Jae
Published: March 2019

In the present work, the performance of spent coffee grounds (SCG) as an adsorbent in the treatment of real soil washing wastewater (SWW) was evaluated. Scanning electron microscopy, Fourier transform infrared spectroscopy, zeta potential measurement and Brunauer–Emmett–Teller analysis were utilized to determine the physicochemical characteristics of SCG. Maximum removal efficiency of 68.73% for Cu(II), 57.23% for Pb(II) and 84.55% for Zn(II) was attained at 2.5 g SCG, 300 min and 328 K. Error analysis was performed using root mean square error (RMSE) and sum of square error (SSE). Equilibrium data correlated well with the Langmuir isotherm for Pb(II) adsorption and Freundlich model for the removal of Cu(II) and Zn(II). The kinetic study shows that adsorption of the heavy metals using SCG can be satisfactorily described using the pseudo-second order equation (R2 ≥ 0.9901; RMSE ≤ 15.0539; SSE ≤ 145.1461). Activation parameters including activation energy, change in free energy of activation, activation entropy change (ΔS*) and activation enthalpy change (ΔH*) were determined using Arrhenius and Eyring equations. Thermodynamic studies show that adsorption of the heavy metals using SCG is spontaneous, endothermic (ΔH° ≥ 9.80 kJ/mol·K) and results in increased randomness at the solid/solution interface (ΔS° ≥ 2.28 J/mol).
Outflow dynamics in a French system of vertical wetlands operating with an extended feeding cycle
Authors: de Andrade Moraes Mirene Augusta , García Zumalacarregui Jorge A. , Trein Camila Maria , Ferreira Vinícius Verna M. , von Sperling Marcos
Published: March 2019

The possibility of using the first stage of the French System (FS) of vertical wetlands composed of only two units in parallel requires hydraulic investigations to allow a better understanding of its operation under tropical climatic environments. This study evaluated the pattern of the outflow hydrograph along an extended cycle of operation (seven days of feeding) and the influence of the sludge deposit, rainfall occurrence and duration of pulse application on the outflow hydrograph in a modified full-scale FS in Brazil. The results indicated that, as the feeding cycle days increased, there was an increase in the time of filtration and the internal storage of the liquid volume, probably due to a reduction in the filter permeability. Greater hydraulic gradient favoured the infiltration velocity, decreased the amount of liquid stored within the system, and delayed the loss of permeability. The sludge layer contributed to a momentary liquid retention, and also allowed greater evapotranspiration, reducing the liquid volume to be treated. The sludge deposit seemed to hinder the liquid percolation, especially at the end of the cycle, modifying the hydraulic conductivity of the filter as a whole. Intense rainfall events demonstrated that precipitation could modify the flow dynamics within the system.
In Vitro, In Silico and Ex Vivo Studies of Dihydroartemisinin Derivatives as Antitubercular Agents
Authors: Kalani Komal , Alam Sarfaraz , Chaturvedi Vinita , Singh Shyam , Khan Feroz , Srivastava Santosh Kumar
Published: March 2019

Introduction:

As a part of our drug discovery program for anti-tubercular agents, dihydroartemisinin
(DHA-1) was screened against Mtb H37Rv, which showed moderate anti-tubercular activity
(>25.0 µg/mL). These results prompted us to carry out the chemical transformation of DHA-1 into
various derivatives and study their antitubercular potential.

Materials and Methods:

DHA-1 was semi-synthetically converted into four new acyl derivatives
(DHA-1A – DHA-1D) and in-vitro evaluated for their anti-tubercular potential against Mycobacterium
tuberculosis H37Rv virulent strain. The derivatives, DHA-1C (12-O-(4-nitro) benzoyl; MIC 12.5
µg/mL) and DHA-1D (12-O-chloro acetyl; MIC 3.12µg/mL) showed significant activity against the
pathogen.

Results:

In silico studies of the most active derivative (DHA-1D) showed interaction with ARG448 inhibiting
the mycobacterium enzymes. Additionally, it showed no cytotoxicity towards the Vero C1008
cells and Mouse bone marrow derived macrophages.

Conclusion:

DHA-1D killed 62% intracellular M. tuberculosis in Mouse bone marrow macrophage infection
model. To the best of our knowledge, this is the first-ever report on the antitubercular potential
of dihydroartemisinin and its derivatives. Since dihydroartemisinin is widely used as an antimalarial
drug; these results may be of great help in anti-tubercular drug development from a very common, inexpensive,
and non-toxic natural product.
LC-MS/MS Method Development and Validation for the Determination of Ilexsaponin A1 and Its Application in Intestinal Bacterial Metabolic Study
Authors: Wu Liang , Kang An , Lin Yujie , Shan Chenxiao , Zhou Zhu , Shi Xuqin , Yu Bin
Published: March 2019

Background:

Ilexsaponin A1, one of the most representative triterpene saponin components
in the roots of I. pubescens, showed its effects in anticoagulation and antithrombosis, attenuating
ischemia-reperfusion-induced myocardial, angiogenesis and inhibiting phosphodiesterase.

Objective:

Reveal the key intestinal bacterial strains responsible for ilexsaponin A1 metabolism, and
clarify their metabolic behavior.

Methods:

An accurate and sensitive LC-MS/MS method for the determination of “ilexsaponin A1 in
General Anaerobic Medium (GAM) broth” was established and systematically validated. Then it was
applied to screen and study the metabolic potential of the intestinal bacterial strains in an anaerobic
incubation system.

Results:

Quantitation of ilexsaponin A1 could be performed within an analytical run time of 14.5 min,
in the linear range of 2 - 2000 ng/ml. Enterobacter sakazakii, Bifidobacterium breve, Bifidobacterium
adolescentis, Bifidobacterium catenulatum, and Bifidobacterium angulatum were identified to have a
potential effect to metabolize ilexsaponin A1 to different extents; and further bacterial metabolic studies
were performed to clarify their metabolic capacity and behavior.

Conclusion:

This paper contributes to a better understanding of the intestinal bacterial metabolism of
ilexsaponin A1 and provides scientific evidence for its clinical application. Additionally, the importance
of intestinal bacterial strains in the disposition of natural products was also highlighted.
Development And Validation of a LC-MS Compatible Method for Quantification of Degradation Impurities of Clofazimine Using UHPLC
Authors: Surya Narayana Murty Nagulakonda Naga Veera Venkata Sri , Bhattacharjee Akash , Krishnamurthy Tatikonda , Rao Muguda Ravi Prasada , Rao Gollapalli Nageswara
Published: March 2019

Background:

Clofazimine has antibacterial and leprostatic properties, which has its use in Multidrug Therapy (MDT) of leprosy. As per the FDA guidance for industry, each NDA and ANDA must include the analytical procedures necessary to ensure the identity, strength, quality, purity, and potency of the drug substance and drug product. However, it was noticed that no stability indicating method is available in the literature for the estimation of degradation impurities of Clofazimine.

Objective:

Objective of the proposed work is to develop and validate a rapid, specific, linear, robust, accurate and sensitive Ultra High-Performance Liquid Chromatography (UHPLC) method with LC-MS compatible mobile phase for the quantification of degradation impurities of Clofazimine in a pharmaceutical dosage form (topical gel 0.5% w/w).

Methods:

Ultra High-Performance Liquid Chromatography equipped with PDA and Tunable UV (TUV) detector at a wavelength of 284 nm, stationary phase with a fused core particle technology, LC-MS compatible mobile phase was employed in this study. Gradient elution was employed for ensuring the selectivity of degradation impurities and clofazimine. This method was validated in accordance with ICH Q2 guidelines. This is the first reported Ultra High-Performance Liquid Chromatography method for estimation of degradation impurities of clofazimine.

Results:

The method showed good linearity over the range of 0.25 -1.5μg/ml of clofazimine. All the validation parameters were within the acceptance criteria. The product is found to degrade in the acid and peroxide degradation condition. The major degradant impurities are eluted at relative retention times of 0.35, 0.89 and 0.95. The developed method successfully separated the degradation products of clofazimine and able to quantitate accurately in its formulation.

Conclusion:

To date, there is no UHPLC method for determination of degradation impurities of clofazimine. in pharmaceutical dosage forms. Being a specific, linear, accurate and robust method, this would help in determining the chemical stability of drug product during the product development as well as in the shelf life of the drug product.
Satisfaction with Orthodontic Care Provided in a University Orthodontic Clinic
Authors: Lyros Ioannis , Elpida Pavi , Tsolakis Apostolos I. , Margarita Makou , John Kyriopoulos
Published: March 2019

Objective:

To evaluate patients’ satisfaction with their orthodontic care at the Department of Orthodontics of University of Athens.

Materials and Methods:

The study sample comprised of 100 individuals whose orthodontic treatment had been completed during the period May to October 2010. A questionnaire was designed and piloted before the telephone interviews were carried out. Questions concerned socio-demographic characteristics, reason for seeking care at the Dental School, level of satisfaction with treatment outcome, fees paid for treatment, and various aspects of organisation of care provision, assessed on 1-very dissatisfied to 5-very satisfied Likert type items.

Results:

Satisfaction score was particularly high as far as treatment outcome (53% were “very satisfied” and 31% were “satisfied”), dentist’s response to an emergency (81% were “very satisfied”), and personnel’s behavior at initial examination (81% were “very satisfied”) were concerned. Factors appearing to require improvement were the waiting time from initial examination to the beginning of treatment, the waiting room and the duration of treatment. Overall satisfaction was found to be significantly associated with total duration of treatment, fees paid by patients, treatment outcome, the behaviour of personnel who conducted first clinical examination, and dentist’s response to an emergency. Overall satisfaction was confirmed as the vast majority of patients (97%) would recommend the Orthodontic Clinic.

Conclusion:

While the Orthodontics Clinic enjoys overall highly satisfied patients, there is scope for improvement of organizational aspects of care provision like the waiting time between the initial examination and the beginning of treatment, the waiting room and the duration of treatment.
Effects of sowing time and spacing on growth and yield of chick pea for green pod
Authors: MACHHAR RG , HAJARI RV , DAMOR CB , HADIYA GD , MAHIDA AK
Published: March 2019

To study the “Effects of sowing time and spacing on growth and yield of chick pea for green pod in Middle Gujarat Agro-Climatic Condition” was conducted at Agricultural Research Station, Anand Agricultural University, Derol during 2015-16 to 2017-18. The experiment was laid out in a Split Plot Design (SPD) with three replications, comprising date of sowing (6) as a main plot and Spacing (2) sub plot of chick pea total thirty six treatment combinations. The results showed that the 1st Oct. (40th Std. week) sowing recorded significantlyhighergreen pod yield (1554, 1713, 1861 and 1709 kg/ha) was found in GG-2 variety during the all the year and pooled analysis.However, in case of spacing S2 (45x10 cm) recorded higher green pod in yield (1144, 1486, 1568 and 1399 kg/ha) was found non-significant during first two year, while significant in third year and pooled analysis.
Evaluation of Productivity and Profitability of Chick pea var. JG-14 through FLD in Irrigated conditions of KaymorePlatue and Satpura Hills
Authors: SINGH DHANANJAI , SINGH ALKA , SINGH RICHA , BAGHEL MS
Published: March 2019

Front line demonstrations (FLD) for improving chick pea production was conducted with high yielding chick pea variety JG-14 along coupled with scientificmanagement practices during three seasons i.e. 2013-14 to 2015-16.Average yield of chick pea was recorded (9.80 q/ha) and (7.06 q/ha)under demonstrated plots and farmers practice respectively. However highest yield was recorded in the FLDs was (10.20 q/ha)and in case of farmers practice (7.80 q/ha). The cultivation of chick pea under improved technologies gave higher net return Rs. 20290, 21745 and 22580 per ha respectively as compared to farmers practices.
Preparation and properties of herbal extract blended pineapple ready to serve
Authors: MANEESHA SR , DEEPIKA S , PREETY L
Published: March 2019

Aqueous extracts of ginger, cumin, lemongrass, mint and holy basil were blended to Pineapple Ready to Serve (RTS) beverages at 5%, 10%, 15% and 20% concentrations and quality parameters and sensory attributes of the products were analyzed. RTS blended with 5% extracts had the highest TSS, titratable acidity and preferable pH. T5 (5 % Cumin extract) recorded the highest TSS (13.2 º Brix) and acidity (0.20 %). The colour indices showed that, the normal light yellow colour of the pineapple RTS had changed to various grades of greenish yellow to brownish yellow by the addition of the herbal extracts at different concentration. In the sensory evaluation, T10 (10 % Lemon grass extract) recorded the highest overall acceptance followed by T9 (5 % Lemon grass extract) and T5 (5 % Cumin extract). Addition of cumin and lemon grass extracts at lower concentration to Pineapple RTS can form a novel beverage with improved physico-chemical properties and consumer acceptance.
Ecological Momentary Assessment of Depressive Symptoms Using the mind.me Application: A Validation Study (Preprint)
Authors: McIntyre Roger S , Rong Carola , Rosenblat Joshua D , Brietzke Elisa , Pan Zihang , Park Caroline , Subramaniapillai Mehala , Ragguett Renee-Marie , Mansur Rodrigo B , Lee Yena , Berriah Said
Published: March 2019

BACKGROUND

Ecological momentary assessment (EMA) for mental disorders has been insufficiently evaluated and validated with rigorous, adequately-powered, high-quality studies.

OBJECTIVE

Herein, we sought to validate the mind.me application (app) for the assessment of depressive symptoms in adults.

METHODS

Adults (ages 18-65) who self-identified as having clinically significant depressive symptoms [i.e. Patient Health Questionnaire 9 (PHQ-9) ≥ 5] utilized the mind.me app—a mobile phone technology that collects data passively and continuously, and is capable of integrating broad multimodal data [e.g., location variance (e.g. GPS), behavioural (e.g. social network activity), and communication data (e.g. SMS texting, phone calls)]. The primary outcome was predictive accuracy (i.e. convergent validity with depressive symptom measurement, as captured by the PHQ-9).

RESULTS

200 subjects were enrolled in the study (mean age 46 ±12.71). The average PHQ-9 score was 12.8 ±6.9. The predictive accuracy of the mind.me app was 0.91 ±0.06. The sensitivity was 0.98 and the specificity was 0.93. The mind.me app was rated by 200 users as highly usable and informative to their illness.

CONCLUSIONS

The mind.me app exhibits robust predictive accuracy in detecting depressive symptoms in adults with clinically relevant depressive symptoms. The mind.me app is one of the first rigorously validated EMA tools for adults capable of detecting depressive symptoms. Future vistas aim to evaluate mind.me’s capability of impacting healthcare and cost outcomes in individuals with mood disorders. The mind.me app provides a unique opportunity for enhanced assay sensitivity in mood disorder research.
Editorial
Authors: Widyandana Doni
Published: March 2019

Editorial
Prevalencia de la cirugía de control de daños en pacientes diagnosticados con trauma abdominal y toracoabdominal en el Hospital Traumatológico Dr. Ney Arias Lora; Período enero 2014-diciembre 2015, Santo Domingo, República Dominicana
Authors: Soto Alejandro , González Violeta , Ramírez Elizabeth , De Jesús Manuel , Mejía Sang Miguel , Guzmán Pérez Laura
Published: March 2019

Objetivo: determinar la prevalencia de la cirugía de con­trol de daños y el impacto sobre la recuperación de los pacientes con trauma abdominal y toracoabdominal.

Materiales y métodos: Se realizó una investigación de tipo observacional, descriptiva y transversal, con informa­ción retrospectiva, donde se revisaron los expedientes de 32 pacientes diagnosticados con trauma abdominal o to­racoabdominal, a los que se les haya realizado la cirugía de control de daños en el Hospital Traumatológico Dr. Ney Arias Lora, en el período enero 2014-diciembre 2015.

Resultados y discusión: El 59% (n=19) de los pacien­tes tenían entre 15-30 años. El 81% (n=26) eran del sexo masculino. El 53% (n=17) presentó trauma cerrado de abdomen, mientras que 44% (n=14) presentó el accidente de vehículo de motor como causa de traumatismo. En los hallazgos quirúrgicos un 31% (n=10) presentó la lesión hepática AAST Grado IV. El 66% (n=21) de los casos no presentó complicaciones, y un 16% (n=5) presentó alte­raciones hemodinámicas. La tasa de mortalidad durante o después de la realización de dicho procedimiento fue de 0.0317 x 1000, lo cual también puede ser expresado como proporción de mortalidad de 32%.

Conclusiones: los jóvenes y adultos del sexo masculino son los más propensos a sufrir accidentes de cualquier tipo, convirtiéndolos en candidatos para la realización de cirugía de control de daños. Se infiere que la mayoría de la población estuvo expuesta a accidentes de vehículo de motor, transformándose éste, en un factor de riesgo para desarrollar trauma cerrado de abdomen.
Síndrome de Turner y embarazo espontáneo: presentación de dos casos
Authors: Carvajal Martínez Francisco , Borges Carcases Danexy , Ávila Baltazar Yisel , Burgos Cabrera Alicia , Piz Ramos Yuraimi
Published: March 2019

Introducción: El Síndrome de Turner constituye la única monosomía completa compatible con la vida. Se produce por la no disyunción meiótica o mitótica de los cromosomas, con expresión variable, que se presenta en el sexo femenino y en el que es extraordinariamente infrecuente el embarazo espontáneo.

Objetivo: Describir dos casos clínicos con diagnóstico de Síndrome de Turner que lograron embarazo espontáneo.

Presentación de los casos clínicos:

Caso 1: Paciente femenina que a los 9 años de edad cronológica es remitida al Departamento de Endocrinología Pediátrica del Instituto Nacional de Endocrinología, por presentar retraso del crecimiento y desarrollo, donde a través de las manifestaciones clínicas y de los exámenes complementarios realizados, se le diagnosticó un Síndrome de Turner 45X/46XX. Recibió tratamiento con hormona de crecimiento biosintética y hormonas sexuales; logrando embarazo espontáneo a los 23 años de edad, y actualmente, tiene una hija de un año y medio.

Caso 2: Paciente femenina que a los de 9.4 años de edad cronológica es remitida al Departamento de Endocrinología Pediátrica del Instituto Nacional de Endocrinología por presentar retraso del crecimiento y desarrollo, donde a través de las manifestaciones clínicas y de los exámenes complementarios realizados, se le diagnosticó un Síndrome de Turner 45X. Recibió tratamiento con hormona de crecimiento biosintética, presentó menarquía espontánea a los 13 años con ciclos menstruales regulares; logró gestación espontánea a los 20 años, interrumpiendo el mismo por decisión personal.

Conclusiones: El embarazo en el Síndrome de Turner es infrecuente. Existe solo una publicación nacional, y muy pocas internacionales, de pacientes con esta afección que logren gestación espontánea. Se plantea que puede existir una línea celular a nivel de ovarios y útero que permite el desarrollo folicular y así lograr la fecundación. En la actualidad las expectativas de fertilidad con este síndrome han cambiado en los últimos años, gracias a los tratamientos de reproducción asistida.
Germinoma pineal como causa de panhipopituitarismo: reporte de un caso
Authors: Lantigua Güichardo Elianny Aimeé , H. Ang Kathleen
Published: March 2019

Introducción: Los tumores de células germinales intracraneales constituyen un grupo infrecuente de neoplasias que afectan principalmente a la población pediátrica. Su presentación clínica varía en función de la localización y el tamaño del tumor. Las lesiones localizadas en la región pineal a menudo causan hidrocefalia obstructiva, mientras que las lesiones de localización supraselar, usualmente se asocian a disfunción del eje hipotálamo-hipofisario. Un tumor germinal de localización pineal que curse con endocrinopatías es una entidad extremadamente rara. Por tanto, reportamos el caso de un paciente masculino de 16 años de edad, con panhipopituitarismo secundario a un germinoma pineal. 

Material y métodos: Este paciente fue referido al Departamento de Emergencias tras presentar hipernatremia en un análisis sanguíneo de rutina. Se presentó con polidipsia, poliuria y fatiga de un año de evolución. Las evaluaciones clínicas y pruebas de laboratorio reportaron diabetes insípida, panhipopituitarismo y hemianopsia bitemporal. El paciente recibió terapia de sustitución hormonal y tres meses después, la resonancia magnética de seguimiento reveló una masa en el área pineal que, a través de una posterior evaluación, fue diagnosticada como germinoma.

Conclusión: Luego de tratamiento con quimioterapia y radiación, hubo una resolución completa de la lesión. Sin embargo, no hubo mejoría clínica significativa y el paciente continúo necesitando terapia de reemplazo hormonal.
Tumor Neuroectodérmico Primitivo Supratentorial (TNEP): a propósito de un caso
Authors: Peña A. Chabela , Roa Batista Adriel , Fernández Josefina , Máquez Johanny , Martial Valentina
Published: March 2019

Introducción: Los tumores neuroectodérmicos primitivos supratentoriales (TNEP) suponen el 2-3% de los tumores cerebrales infantiles. Se suelen presentar en la primera década de la vida, y están constituido por células neuroepiteliales indiferenciadas o poco diferenciadas, teniendo un comportamiento agresivo y rápida evolución.

Material y métodos: Se describe el caso de un lactante de 3 meses de edad, con diagnóstico inicial de meningitis bacteriana, manejado con antibioticoterapia. Al no evidenciarse evolución del cuadro, se realizan imágenes y pruebas imnunohistoquímicas que arrojan el diagnóstico de un TNEP localizado en región fronto-temporal derecha, de rápida progresión clínica hacia la muerte.

Conclusion: La acelerada evolución y la agresividad con la que se comportan estos tumores representa un alto nivel de mortalidad, su diagnóstico y tratamiento oportuno son vital para una evolución favorable del cuadro.
Casos de parálisis flácida aguda reportados para descartar polio en la República Dominicana entre 2001 y 2017: revisión de sus factores etiopatológicos
Authors: Santoni Juan , Garib Zacarias , Mancebo Pablo , Santoni Carlos , Grullón Patricia , Rodríguez Antolina
Published: March 2019

Introducción: Tras 18 casos de poliomielitis descubiertos al final del 2000, en Constanza, el Ministerio de Salud Pública (MSP) y la Organización Panamericana de la Salud (OPS), comparten la responsabilidad de revisar, a los 60 días, todos los casos de Parálisis Flácidas Agudas (PFA). Para examinarlos se nombra un comité de pro­fesores (Tolentino, Mendoza, Santoni). Las entidades comprometidas habían publicado las características clí­nico-epidemiológicas del brote, mientras que J.Santoni y C.Santoni Williams publican su electromiografía. Para este artículo se revisa la literatura de etiopatogenias en la PFA y polio.

Métodos: Se citan 336 casos acompañados por encargados comunitarios, 188 varones, 148 hembras, edad promedio: 6.2 años. Se revisa: evolución, imágenes, analítica, cultivo viral en heces. Así mismo, diagnóstico y clasificación tras examen neurológico.

Resultados: Casos de poliomielitis (18), de 1 a 13 años: todos vacunados irregularmente. Citamos patología de membrana CD155 y del cañón neuronal. Describimos los casos de PFA en orden descendente; síndromes de Guillain-Barré (84), 10 de ellos Miller-Fisher; evolución moderada, 2 fallecidos. Se atribuye a mímica proteica de oligosacáridos. Casos de FPA que involucran a las cito­kinas; mielitis y encefalomielitis diseminada agudas (58); encefalitis, meningitis, cerebelitis (49); polineuritis/mono­neuritis (23); miopatías relacionadas a Estreptococias (25) con sus 6 Coreas por mímica proteica anti-lysogangliosi­do GM1; procesos entero virales (16), vasculitis con ACV escasos (11), tumores (10). Finalmente, encontramos 15 con exámenes asimétricos sospechosos de motoneurona lesionada, pero todos con cultivos fecales de poliovirus negativos; y 24 exámenes neurológicos normales, pero sin causa. Aceptamos 3 inasistencias.

Conclusión: Demostramos la ausencia de nuevos casos de polio y actualizamos la clasificación de las PFA. Revisando sus etiopatogenias las entendemos mejor.