bluuebunny/crossref_metadata_2025 huggingface dataset:
Rapid facial mimicry as a regulator of play in a despotic macaque species
Authors: Facondini Giulia , Pedruzzi Luca , Aere Simone , Böye Martin , Lemasson Alban , Palagi Elisabetta
Published: May 2024

During risky interactions like social play, motor resonance phenomena such as facial mimicry can be highly adaptive. Here, we studied Rapid Facial Mimicry (RFM, the automatic mimicking of a playmate’s facial expression, play faces) during play fighting between young rhesus macaques (Macaca mulatta) living in a large zoo-housed group. For the first time and in contrast to previous data on highly despotic-intolerant macaques, we found RFM to be present at high frequency in young rhesus macaques, especially when the trigger was dominant over the responder and when both players were subadults. The hierarchical modulation of RFM may be associated with the increased uncertainty and riskiness of play involving a higher-ranking playmate. This highlights the importance of mimicry in improving communication and coordination during such interactions. Interestingly, RFM prolonged playful sessions, possibly indicating a more effective fine-tuning of motor patterns. Moreover, the occurrence of RFM had an effect on shortening the latency to restart playing after a break, possibly acting as an engine to potentially maintain playmates’ arousal. When investigating if bystanders could replicate play faces emitted by the playing subjects, we failed to find RFM, thus highlighting that being directly involved in the interaction might be crucial for RFM activation in monkeys. Even though further comparative studies should investigate the role of RFM across tolerant and despotic-intolerant species, our findings offer valuable insights into the communicative and adaptive value of motor resonance phenomena in regulating social play in despotic societies.

Significance statement

In risky interactions involving competition and vigorous physical contact, such as play fighting, replicating partners’ facial expressions can serve as a strategy to convey positive mood and intentions. Here we investigated the presence and possible roles of Rapid Facial Mimicry (RFM) in rhesus macaques (Macaca mulatta). For the first time, our study demonstrates that communicative strategies, including Rapid Facial Mimicry (RFM), can be both present and frequent in despotic-intolerant macaque species. We demonstrate that the role of mimicry not only prolongs playful interactions but can also be linked to the reinforcement and/or transmission of playful arousal. Our study shows how the adaptive value of motor resonance phenomena may have driven their evolution to cope with challenges during social interactions also for despotic-intolerant species.
Exploring the Personality Characteristics of Rhinoplasty Patients: Perfectionism, Rumination, and Self-Compassion
Authors: Mete Utku , Demir Uygar Levent , Güllülü Rümeysa Ayşe , Eker Salih Saygin , Duman Fatih , Altun Nadir
Published: May 2024

Objective

This study investigates differences in personality characteristics, including perfectionism, ruminative thinking style, and self-compassion, between individuals who have undergone rhinoplasty and a control group without any history of cosmetic surgery.

Methods

The study included 33 adult patients who underwent rhinoplasty between 2021 and 2023 at Bursa Uludağ University Faculty of Medicine Hospital and 33 adult patients who visited our centre for other complaints as a control group. The rhinoplasty group consisted of primary surgical patients with functional and cosmetic concerns, excluding those who sought revision surgery or had only functional problems. The control group consisted of individuals with no prior cosmetic surgery history and no expectations of aesthetic interventions. Psychiatric analysis was performed using Frost multidimensional perfectionism scale, ruminative thinking style questionnaire, and self-compassion scale.

Results

This research revealed that individuals who had rhinoplasty scored higher in perfectionism 109.3 (±23.3) and ruminative thinking 87.9 (±22) compared to those who did not undergo surgery 94.15 (±22.2) and 77.7 (±23), respectively. Additionally, the rhinoplasty group had lower self-compassion scores, 80.4 (±17.3), than the control group, 86.1 (±11.2). Statistically significant differences were observed in perfectionism between the groups (p = 0.009). In rhinoplasty patients, a notably positive correlation was found between perfectionism and ruminative thinking scores (r = 0.482; p = 0.005), while a moderately significant negative correlation was observed between self-compassion and ruminative thinking scores (r = − 0.465; p = 0.006).

Conclusion

Individuals who undergo rhinoplasty generally show increased levels of perfectionism and are more prone to ruminative thinking. They also demonstrate reduced self-compassion compared to non-surgical control groups. Cosmetic surgeons should be aware of these psychological trends and consider using appropriate scales during pre-surgery consultations and follow-up visits. Adopting this informed approach can improve the surgeon–patient relationship and help overcome communication challenges.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Periocular Asymmetry Index in Caucasian Populations Using Three-dimensional Photogrammetry Assessment
Authors: Ju Xiaojun , Rokohl Alexander C. , Fan Wanlin , Simon Michael , Li Xueting , Hou Xincen , Ukehajdaraj Nexhat , Wawer Matos Philomena A. , Guo Yongwei , Heindl Ludwig M.
Published: May 2024

Objective

To quantitatively assess the periocular asymmetry and investigate its sex and age-related differences in a Caucasian population using three-dimensional (3D) stereophotogrammetry.

Method

Standardized 3D photos of the periocular region of 301 Caucasians were taken using the VECTRA M3 3D Imaging System. Standardized landmarks were positioned, and data measurements in the periocular region were obtained from these images using VAM software and assessed using intraclass correlation coefficients (ICC) for reliability. Absolute differences and asymmetry index between the right and the left periocular region were calculated with a focus on gender and age-related differences.

Result

Fissure height asymmetry was positively correlated with age (p < 0.01). Furthermore, reflex distance asymmetry was positively correlated with age in the elderly group (p < 0.05). Absolute differences of upper eyelid crease were 0.65 ± 0.79 mm for females and 0.90 ± 0.94 mm for males (p < 0.05). In the elderly group, the absolute differences of reflex distance were 0.664 ± 0.471 mm for males and 0.470 ± 0.408 mm for females (p < 0.05), while the absolute differences of fissure height were 0.619 ± 0.469 mm and 0.436 ± 0.372 mm, respectively (p < 0.05). All measurements had an inter-rater ICC and intra-rater ICC between 0.761 and 0.957.

Conclusion

Periocular asymmetry is more prominent in older and male people. 3D photogrammetry is a reliable tool to detect periocular asymmetry and might provide an accurate and effective reference for periocular cosmetic, plastic, and reconstructive surgery in the clinical routine.

Level of Evidence I

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors. www.springer.com/00266.
Investigating the effect of plant growth regulators in the endodormancy release in apricot by a metabolomic approach
Authors: Guillamón Guillamón Jesús , Andreu-Ardil Laura , Dicenta Federico , Ruiz David , López-Marqués Rosa Laura , Sánchez-Pérez Raquel
Published: May 2024

Endodormancy is one of the most studied physiological processes in perennial plants like apricot. This period is vital both for the tree survival against the adverse climatic conditions of winter and for obtaining a proper flowering and fruit set. Many studies have remarked the importance of chill accumulation as the limiting factor for endodormancy release. The increase of mean temperatures caused by climate change has been seriously endangering this process during the last decades. Because of this, plant growth regulators for promoting endodormancy release have spread worldwide. However, due to the toxicity and the irregular efficiency, there is a great necessity of developing new environment-friendly regulators for promoting endodormancy release. In this 3-year study, we applied four different commercial plant growth regulators to the Flopría apricot cultivar. Two of them, Broston® and Erger® were the most effective ones to advance endodormancy release. The physiology and biochemistry behind these treatments were studied by a non-target metabolomic and expression analysis in flower buds. Metabolic groups, like phospholipids, only varied in treated samples, whereas others like by-products of L-Phe metabolism, or ABA significantly varied in both types of samples throughout endodormancy release. Finally, to validate these results, solutions of phospholipids, phenylpropanoids, or ABA, among others, were applied for the first time to apricot trees, showing, i.e., that phospholipids treated-trees released from endodormancy two weeks earlier than control. This study aims to be an initial stage for the elaboration of environmentally safe regulators in apricot, with a potential in other Prunus and temperate fruit tree species.
Reduced contrast sensitivity, pattern electroretinogram ratio, and diminished a-wave amplitude in patients with major depressive disorder
Authors: Friedel Evelyn B. N. , Tebartz van Elst Ludger , Beringer Malina , Endres Dominique , Runge Kimon , Maier Simon , Kornmeier Jürgen , Bach Michael , Domschke Katharina , Heinrich Sven P. , Nickel Kathrin
Published: May 2024

The electroretinogram (ERG), a non-invasive electrophysiological tool used in ophthalmology, is increasingly applied to investigate neural correlates of depression. The present study aimed to reconsider previous findings in major depressive disorder (MDD) reporting (1) a diminished contrast sensitivity and (2) a reduced patten ERG (PERG) amplitude ratio, and additionally, to assess (3) the photopic negative response (PhNR) from the flash ERG (fERG), with the RETeval® device, a more practical option for clinical routine use. We examined 30 patients with a MDD and 42 healthy controls (HC), assessing individual contrast sensitivity thresholds with an optotype-based contrast test. Moreover, we compared the PERG ratio, an established method for early glaucoma detection, between both groups. The handheld ERG device was used to measure amplitudes and peak times of the fERG components including a-wave, b-wave and PhNR in both MDD patients and HCs. MDD patients exhibited diminished contrast sensitivity together with a reduced PERG ratio, compared to HC. With the handheld ERG device, we found reduced a-wave amplitudes in MDD, whereas no significant differences were observed in the fERG b-wave or PhNR between patients and controls. The reduced contrast sensitivity and PERG ratio in MDD patients supports the hypothesis that depression is associated with altered visual processing. The findings underscore the PERG’s potential as a possible objective marker for depression. The reduced a-wave amplitude recorded with the RETeval® system in MDD patients might open new avenues for using handheld ERG devices as simplified approaches for advancing depression research compared to the PERG.
Progression independent of relapse activity in relapsing multiple sclerosis: impact and relationship with secondary progression
Authors: Portaccio Emilio , Betti Matteo , De Meo Ermelinda , Addazio Ilaria , Pastò Luisa , Razzolini Lorenzo , Totaro Rocco , Spitaleri Daniele , Lugaresi Alessandra , Cocco Eleonora , Onofrj Marco , Di Palma Franco , Patti Francesco , Maimone Davide , Valentino Paola , Torri Clerici Valentina , Protti Alessandra , Ferraro Diana , Lus Giacomo , Maniscalco Giorgia Teresa , Brescia Morra Vincenzo , Salemi Giuseppe , Granella Franco , Pesci Ilaria , Bergamaschi Roberto , Aguglia Umberto , Vianello Marika , Simone Marta , Lepore Vito , Iaffaldano Pietro , Comi Giancarlo , Filippi Massimo , Trojano Maria , Amato Maria Pia ,   the Italian Multiple Sclerosis Register
Published: May 2024

Objectives

We investigated the occurrence and relative contribution of relapse-associated worsening (RAW) and progression independent of relapse activity (PIRA) to confirmed disability accrual (CDA) and transition to secondary progression (SP) in relapsing multiple sclerosis (MS).

Methods

Relapsing-onset MS patients with follow-up > / = 5 years (16,130) were extracted from the Italian MS Registry. CDA was a 6-month confirmed increase in Expanded Disability Status Scale (EDSS) score. Sustained disability accumulation (SDA) was a CDA with no EDSS improvement in all subsequent visits. Predictors of PIRA and RAW and the association between final EDSS score and type of CDA were assessed using logistic multivariable regression and multivariable ordinal regression models, respectively.

Results

Over 11.8 ± 5.4 years, 16,731 CDA events occurred in 8998 (55.8%) patients. PIRA (12,175) accounted for 72.3% of CDA. SDA occurred in 8912 (73.2%) PIRA and 2583 (56.7%) RAW (p < 0.001). 4453 (27.6%) patients transitioned to SPMS, 4010 (73.2%) out of 5476 patients with sustained PIRA and 443 (24.8%) out of 1790 patients with non-sustained PIRA. In the multivariable ordinal regression analysis, higher final EDSS score was associated with PIRA (estimated coefficient 0.349, 95% CI 0.120–0.577, p = 0.003).

Discussion

In this real-world relapsing-onset MS cohort, PIRA was the main driver of disability accumulation and was associated with higher disability in the long term. Sustained PIRA was linked to transition to SP and could represent a more accurate PIRA definition and a criterion to mark the putative onset of the progressive phase.
Exploratory study to evaluate the acceptability of a wearable accelerometer to assess motor progression in motor neuron disease
Authors: Beswick Emily , Christides Alexander , Symonds Alexander , Johnson Micheaela , Fawcett Thomas , Newton Judith , Lyle Dawn , Weaver Christine , Chandran Siddharthan , Pal Suvankar
Published: May 2024

Motor neuron disease (MND) is a rapidly progressive condition traditionally assessed using a questionnaire to evaluate physical function, the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R). Its use can be associated with poor sensitivity in detecting subtle changes over time and there is an urgent need for more sensitive and specific outcome measures. The ActiGraph GT9X is a wearable device containing multiple sensors that can be used to provide metrics that represent physical activity. The primary aim of this study was to investigate the initial suitability and acceptability of limb-worn wearable devices to group of people with MND in Scotland. A secondary aim was to explore the preliminary associations between the accelerometer sensor data within the ActiGraph GT9X and established measures of physical function. 10 participants with MND completed a 12-week schedule of assessments including fortnightly study visits, both in-person and over videoconferencing software. Participants wore the device on their right wrist and right ankle for a series of movements, during a 6-min walking test and for a period of 24-h wear, including overnight. Participants also completed an ALSFRS-R and questionnaires on their experience with the devices. 80% of the participants found wearing these devices to be a positive experience and no one reported interference with daily living or added burden. However, 30% of the participants experienced technical issues with their devices. Data from the wearable devices correlated with established measures of physical function.
Temporal dynamics of RAS mutations in circulating tumor DNA in metastatic colorectal cancer: clinical significance of mutation loss during treatment
Authors: Iguchi Kenta , Shiozawa Manabu , Uchiyama Mamoru , Asari Masahiro , Numata Koji , Rino Yasushi , Saito Aya
Published: May 2024

Purpose

In metastatic colorectal cancer (mCRC), RAS mutation loss may occur during the standard-of-care regimen. In this study, we aimed to investigate the temporal dynamics of the RAS gene and its clinical significance.

Methods

This was a retrospective, single-center study that included 82 patients with tissue RAS-mutant (RAS-MT) mCRC who underwent circulating tumor DNA (ctDNA) RAS monitoring between January, 2013–April, 2023. Patients were analyzed for the rate of change over time to acquired RAS mutation loss (aRAS-ML) and clinicopathological factors. The prognostic relevance of mutation loss was assessed.

Results

aRAS-ML was detected in 33 (40.2%) patients, 32 of whom had a mutation loss in the first ctDNA RAS assay. Patients with a RAS mutation detected in the first assay had a median time of 8 months until the second ctDNA RAS assay, with 4.5% cases newly converted to aRAS-ML; no new conversions were detected at the third assay. The aRAS-ML group exhibited more single-organ metastases in the target organ during ctDNA measurement (aRAS-ML: 84.8% vs. RAS-MT: 59.2%, p = 0.02). Of the 33 patients with aRAS-ML, seven (21.2%) received anti-epidermal growth factor receptor (EGFR) therapy, with a median progression-free survival of 8 months. Multivariate analysis revealed that persistent ctDNA RAS mutation was an independent prognostic factor for overall survival (hazard ratio: 2.7, 95% confidence interval: 1.1–6.3, p = 0.02).

Conclusion

The rate of ctDNA mutation loss in patients with RAS-MT mCRC decreases over time. Therefore, using a ctDNA RAS assay early in treatment will assist in challenging the use of EGFR regimens.
Review of the creep constitutive models for rocks and the application of creep analysis in geomechanics
Authors: Tarifard Abolfazl , Török Ákos , Görög Péter
Published: May 2024

The creep behavior of rocks has been broadly researched because of its extensive application in geomechanics. Since the time-dependent stability of underground constructions is a critical aspect of geotechnical engineering, a comprehensive understanding of the creep behavior of rocks plays a pivotal role in ensuring the safety of such structures. Various factors, including stress level, temperature, rock damage, water content, rock anisotropy, etc., can influence rocks’ creep characteristics. One of the main topics in the creep analysis of rocks is the constitutive models, which can be categorized into empirical, component, and mechanism-based models. In this research, the previously proposed creep models were reviewed, and their main characteristics were discussed. The effectiveness of the models in simulating the accelerated phase of rock creep was evaluated by comparing their performance with the creep test results of different types of rocks. The application of rock’s creep analysis in different engineering projects and adopting appropriate creep properties for rock mass were also examined. The primary limitation associated with empirical and classical component models lies in their challenges when it comes to modeling the tertiary phase of rock creep. The mechanism-based models have demonstrated success in effectively simulating the complete creep phases; nevertheless, additional validation is crucial to establish their broader applicability. However, further investigation is still required to develop creep models specific to rock mass. In this paper, we attempted to review and discuss the most recent studies in creep analysis of rocks that can be used by researchers conducting creep analysis in geomechanics.
Histological assessment of a novel de-epithelialization method for connective tissue grafts harvested from the palate. An experimental study in cadavers
Authors: Bara-Gaseni Natalia , Jorba-Garcia Adria , Alberdi-Navarro Javier , Figueiredo Rui , Bara-Casaus Jose-Javier
Published: May 2024

Objectives

This study aims to compare the histological outcomes of three distinct de-epithelialization methods used in (connective tissue grafts) CTG harvested from the palate.

Materials and methods

An experimental study using nine cadaver head specimens was carried out to compare 3 different de-epithelialization techniques for CTG. Eighteen samples were randomly allocated to three study groups: bone scraper, diamond bur and extraoral removal with a scalpel. The main outcome variable was the graft surface percentage without epithelium remains. Additionally, the time employed, and the graft thickness were also measured.

Results

Sixteen CTGs were analyzed. The extraoral scalpel group presented a total surface area with no epithelium of 58.84% (22.68) and a mean de-epithelialization time of 3.7 min; the intraoral diamond bur group had 88.24% (41.3) of the surface with no epithelium and took 1.455 min, and the intraoral bone scraper showed 97.98% (5.99) of surface without epithelium and a mean time of 0.815 min (P < 0.05). Histological analysis showed significant differences between the bone scraper and the extraoral group (P = 0.009).

Conclusion

The de-epithelialization technique with a bone scraper seems to be the most effective and fastest de-epithelialization technique for CTG. These findings need to be confirmed in future clinical studies with larger samples.

Clinical relevance

The use of bone scrapers, could be a simple, effective and fast technique to de-epithelialize connective tissue grafts harvested from the palatal area for both novice and experienced surgeons.
Neural Circuit Policies for Virtual Character Control
Authors: Razzaq Waleed , Raza Kashif
Published: May 2024

The development of high-stakes decision-making neural agents that interact with complex environments, such as video games, is an important aspect of AI research with numerous potential applications. Reinforcement learning combined with deep learning architectures (DRL) has shown remarkable success in various genres of games. The performance of DRL is heavily dependent upon the neural networks resides within them. Although these algorithms perform well in offline testing but the performance deteriorates in noisy and sub-optimal conditions, creating safety and security issues. To address these, we propose a hybrid deep learning architecture that combines a traditional convolutional neural network with worm brain-inspired neural circuit policies. This allows the agent to learn key coherent features from the environment and interpret its dynamics. The obtained DRL agent was not only able to achieve an optimal policy quickly, but it was also the most noise-resilient with the highest success rate. Our research indicates that only 20 control neurons (12 inter-neurons and 8 command neurons) are sufficient to achieve competitive results. We implemented and analyzed the agent in the popular video game Doom, demonstrating its effectiveness in practical applications.
Factors determining changes in the network of marked hiking trails in the Sudetes
Authors: Kołodziejczyk Krzysztof
Published: May 2024

Hiking trails are a basic type of tourist infrastructure, which, on the one hand, make areas available for tourist traffic, and on the other hand, can contribute to the protection of the natural environment (if they are well designed and maintained). Owing to the variety of performed functions, their designation is determined by several factors: natural, technical, economic, social. Networks of trails change constantly. The aim of this article is to determine exactly what factors influence transformations within the hiking trail networks and what is their significance. To this end, three study areas in the Sudetes were analysed: one on the Polish side of the Sudetes–the Table (Stołowe) Mountains, and two on the Czech side–the rock town near the village of Sloup v Čechách and the central part of Zlatohorská vrchovina. An analysis of changes in the shape of the networks over time was carried out, as well as surveys of institutions that were responsible for or influenced these transformations. These areas are characterised by a significant level of changes in the trail network. Among the factors influencing these changes, the tourist attractiveness of the area, the resilience of the environment, the intensity of tourism traffic, the environmental transformations associated with it, the history of tourism development and land ownership changes should be considered the most important. At each stage of forming networks, the key factor should be tourists’ needs, including the desire to escape the urbanised environment. For this reason, trails should avoid roads with artificial (hard) surfaces and heavy automobile traffic.
Coherent beam combining of two all-PM thulium-doped fiber chirped pulse amplifiers
Authors: Ren Bo , Chang Hongxiang , Li Can , Wang Tao , Jin Kaikai , Zhang Jiayi , Guo Kun , Su Rongtao , Leng Jinyong , Zhou Pu
Published: May 2024

In this paper, we report a coherent beam combining (CBC) system that involves two thulium-doped all-polarization maintaining (PM) fiber chirped pulse amplifiers. Through phase-locking the two channels via a fiber stretcher by using the stochastic parallel gradient descent (SPGD) algorithm, a maximum average power of 265 W is obtained, with a CBC efficiency of 81% and a residual phase error of λ/17. After de-chirping by a pair of diffraction gratings, the duration of the combined laser pulse is compressed to 690 fs. Taking into account the compression efficiency of 90% and the main peak energy proportion of 91%, the corresponding peak power is calculated to be 4 MW. The laser noise characteristics before and after CBC are examined, and the results indicate that the CBC would degrade the low frequency relative intensity noise (RIN), of which the integration is 1.74% in [100 Hz, 2 MHz] at the maximum combined output power. In addition, the effects of the nonlinear spectrum broadening during chirped pulse amplification on the CBC efficiency are also investigated, showing that a higher extent of pulse stretching is effective in alleviating the spectrum broadening and realizing a higher output power with decent combining efficiency.

Graphical Abstract
Protosappanin B enhances the chemosensitivity of 5-fluorouracil in colon adenocarcinoma by regulating the LINC00612/microRNA-590-3p/Golgi phosphoprotein 3 axis
Authors: Hong Zhongshi , Li Yachen , Chen Mingliang , Chen Xiaojing , Deng Xian , Wu Yuze , Wang Chunxiao , Qiu Chengzhi
Published: May 2024

Background

5-fluorouracil (5-FU) is conventionally used in chemotherapy for colon adenocarcinomas. Acquired resistance of 5-FU remains a clinical challenge in colon cancer, and efforts to develop targeted agents to reduce resistance have not yielded success. Protosappanin B (PSB), the main component of Lignum Sappan extract, is known to exhibit anti-tumor effects. However, whether and how PSB could improve 5-FU resistance in colon cancer have not yet been established. In this study, we aimed to explore the effects and underlying mechanisms of PSB in 5-FU-induced chemoresistance in colon adenocarcinoma.

Methods

Forty-seven paired colon cancer tissue samples from patients who received 5-FU chemotherapy were collected as clinical samples. Two 5-FU resistant colon cancer cell lines were established for in vitro experiments. Reverse transcription-quantitative PCR (RT-qPCR) was performed to determine the mRNA and microRNA (miRNA) expression levels in colon adenocarcinoma tissues and cell lines. Cell Counting Kit-8 (CCK-8) and flow cytometry assays were performed to evaluate cell proliferation and apoptosis, respectively.

Results

LINC00612 was highly expressed in colon adenocarcinoma samples and 5-FU resistant colon cancer cells. LINC00612 knockdown enhances 5-FU chemosensitivity in 5-FU resistant cells. Notably, PSB treatment attenuated LINC00612 expression in 5-FU resistant colon adenocarcinoma cells. Moreover, PSB treatment reversed the increase in LINC00612-induced 5-FU resistance. Mechanistically, LINC00612 specifically bound to miR-590-3p, which promoted 5-FU resistance in colon adenocarcinoma cells and attenuated the inhibitory effect of LINC00612 on GOLPH3 expression.

Conclusion

PSB attenuates 5-FU chemoresistance in colon adenocarcinoma by regulating the LINC00612/miRNA-590-3p/GOLPH3 axis.

Graphical Abstract
Challenges in assessing the immunization status of adults in Germany—lessons from a population-based VACCELERATE survey on polio vaccination
Authors: Nacov Julia A. , Stemler Jannik , Salmanton-García Jon , Cremer Louise M. , Zeitlinger Markus , Mallon Patrick W. G. , Pana Zoi Dorothea , Schmitt Heinz-Josef , Cornely Oliver A. ,   On behalf of the VACCELERATE Consortium
Published: May 2024

Purpose

Considering the re-emergence of poliomyelitis (PM) in non-endemic regions, it becomes apparent that vaccine preventable diseases can rapidly develop epi- or even pandemic potential. Evaluation of the current vaccination status is required to inform patients, health care providers and policy makers about vaccination gaps.

Methods

Between October 28 2022 and November 23 2022, 5,989 adults from the VACCELEREATE Volunteer Registry completed an electronic case report form on their previous PM vaccine doses including number, types/-valencies and the time of administration based on their vaccination records. A uni-/multivariable regression analysis was performed to assess associations in participant characteristics and immunization status.

Results

Among German volunteers (n = 5,449), complete PM immunization schedule was found in 1,981 (36%) participants. Uncertain immunization, due to unknown previous PM vaccination (n = 313, 6%), number of doses (n = 497, 9%), types/-valencies (n = 1,233, 23%) or incoherent immunization schedule (n = 149, 3%) was found in 40% (n = 2,192). Out of 1,276 (23%) participants who reported an incomplete immunization schedule, 62 (1%) never received any PM vaccine. A total of 5,074 (93%) volunteers reported having been vaccinated at least once and 2,087 (38%) indicated that they received vaccination within the last ten years. Female sex, younger age, as well as availability of first vaccination record were characteristics significantly associated with complete immunization (p < 0.001).

Conclusion

Full PM immunization schedule was low and status frequently classified as uncertain due to lack of details on administered doses. There is an obviousneed for improved recording to enable long-term access to detailed vaccination history in the absence of a centralized immunization register.
Smoking habits and osteoporosis in community-dwelling men subjected to dual-X-ray absorptiometry: a cross-sectional study
Authors: Vergatti A. , Abate V. , D’Elia L. , De Filippo G. , Piccinocchi G. , Gennari L. , Merlotti D. , Galletti F. , Strazzullo P. , Rendina D.
Published: May 2024

Background

Active and Environmental Tobacco Smoke (ETS) are a global cause of death. Osteoporosis (Op) is the most common metabolic bone disorder worldwide, impacting on mortality and disability, with high health and welfare costs. Active smoking is a known risk factor for Op, but there is few information regarding Op and ETS in men.

Purpose

The study aim is to evaluate the association between smoking habits and Op in community-dwelling men that have been subjected to Dual-X-ray Absorptiometry and completed a questionnaire about their own and cohabiter’s smoking habits.

Methods

We performed a cross-sectional study based on administrative data. This study is part of the SIMON protocol. The binary logistic regression analysis was used to estimate the role of ETS on the risk of Op, adjusting for age, body mass index (BMI), type 2 diabetes mellitus (T2DM) and eGFR.

Results

Four hundred sixteen men were selected and, based on questionnaire replies, 167 were classified as current smokers (CS), 93 as passive smokers (PS) and 156 as never smokers (NS). NS showed a lower prevalence of past fragility fracture, radiological features of osteoporosis and hypovitaminosis D compared to PS and CS (p < 0.05). NS showed a lower prevalence of Op compared to PS and CS, also after correction for age, BMI, T2DM and eGFR (p < 0.05).

Conclusion

The study results demonstrate that PS and CS have a higher risk of Op, fragility fractures and vitamin D deficiency compared to NS.
A Strategic NH3-Dosing Approach for the Minimization of N2O Production During NH3-SCR Reactions over Cu-SSZ-13 Catalysts
Authors: Nasello Nicole Daniela , Usberti Nicola , Nova Isabella , Tronconi Enrico , Hofmann Frank , Dieterich Simone , Crocoll Marcus , Weibel Michel
Published: May 2024

The undesired production of N2O during NH3-SCR reactions is investigated over a reference commercial Cu-CHA catalyst. Steady-state experiments performed in the 150–500 °C temperature range exhibit a bimodal trend in the N2O formation profile, confirming the existence of two different reaction mechanisms occurring at low and high temperatures. Focusing on a low-to-medium T-range, N2O production, usually ascribed to NH4NO3 formation and decomposition, increases with the NO2/NOx ratio. However, an excess of NO2 leads to a decrease in the N2O release due to ammonium nitrate deposition and catalyst clogging phenomena. Steady-state and dynamics experiments show the promoting effect of both NH3 feed concentration and NH3 storage on N2O production at T > 200 °C. Surprisingly, N2O decreases with increasing NH3/NOx ratio at lower temperature. A novel approach based on the strategic injection of NH3 is also applied to mitigate the N2O formation while maintaining high deNOx activity. Remarkably, complete NOx conversion and ~ 11% N2O saving are achieved (with inlet NO2/NOx = 0–0.5) at temperatures exceeding 200 °C; in addition, a peculiar behavior is observed in the N2O profile, which increases and decreases when adding and removing NH3 from the feed, respectively. Notably, the opposite trend is observed in the N2O profile at 200 °C. When under Standard SCR conditions, this so far unreported observation challenges the NH4NO3 formation route for N2O and suggests the existence of different controlling phenomena at different temperature regimes: i) the Cu/redox chemistry at T ≤ 200 °C and ii) the NH3 storage at higher temperature, ideally up to 300 °C.
Logistik des Schönen
Authors: Stöckmann Ingo
Published: May 2024

Zusammenfassung-

Der Aufsatz rekonstruiert zunächst Bernard Bolzanos Ästhetik als paradigmatisches Exempel für die in Deutschland marginalisierte logisch-semantische Ästhetik-Tradition in der Leibniz-Nachfolge und schließt mit Perspektiven für eine künftige Rekonstruktion der nachhegelschen Ästhetik im Zeichen des Bedeutungsproblems, wie es zu Beginn des 20. Jahrhunderts im Kontext von Semantik, sprachanalytischer Philosophie und Linguistik virulent wird. Damit rückt das vermeintlich idealistisch geprägte 19. Jahrhundert in eine Kontinuität mit Theorieentwicklungen, die im Gefolge des linguistic turn die unhintergehbare Sprachlichkeit und zeichenhafte Strukturiertheit aller Bedeutung betonen.
Smart home energy management systems in India: a socio-economic commitment towards a green future
Authors: George Thomas , Selvakumar A. Immanuel
Published: May 2024

A smart home energy management system plays an important role in improving the efficiency of an energy distribution system and also helps to reduce the carbon footprint of the power utility company. For a developing country like India, one of the main challenges faced while integrating an energy management system and renewable energy technology is the migration cost faced by the user from the existing system. The existing energy policy of the nation or the community should be reformed in such a way that the user who is willing to adapt to an energy management system should be properly rewarded. Smart appliances and IoT-enabled devices reduce wiring complexity in any conventional home and the smart metering facility aids in the bidirectional communication between consumers and utility companies. But how does it take care of user privacy? What are the reasons behind the user’s negligence on-demand response schemes in India? Through a case study, it was observed that the power consumption of domestic consumers in India increased over the years. It was also observed through an energy survey of 200 low-tension domestic consumers that a simple reengineering of lighting loads can save up to 4.68 Megawatt-hour of energy in a year. The paper also identified the negative impact of the inclining block rate billing scheme by comparing the bimonthly energy consumption pattern of consumers and also proposed a new billing scheme. The paper also reviews the types of optimization methods available for load scheduling. This paper is an attempt to enlighten readers on the importance of adopting a sustainable home energy management system, as a socio-economic commitment towards a green future.
A novel membrane-less microbial fuel cell reactor using wood as container and separator to prevent air–cathode deterioration and biofouling
Authors: Tahir Chenar A. , Agarwal Charu , Pásztory Zoltán , Csóka Levente
Published: May 2024

In this study, we introduce a novel application of wood as the construction material for Microbial Fuel Cell (MFC) containers, developing what we term the Wooden Membrane-less Microbial Fuel Cell (WML-MFC). This innovative approach leverages the natural properties of wood to enhance the sustainability and cost-effectiveness of MFCs. Employing three different types of wood—pine, oak, and black locust—the WML-MFC design incorporates a carbon felt anode inside the wooden container and a carbon cloth cathode wrapped externally. This configuration not only protects the cathode from biofouling but also utilizes the inherent moisture management capabilities of wood to maintain operational stability. The performance of these wooden MFCs was assessed in terms of electricity generation and water treatment efficacy. Pine and oak containers achieved maximum power densities (MPD) of 35 mW/m^2 and 4 mW/m^2, respectively, with corresponding maximum open-circuit voltages of 551 mV and 269 mV. Black locust showed the least effective bioelectricity generation. COD removal efficiency was observed between 18 and 48% for pine and 3% to 39% for oak over hydraulic retention times of 24–48 h. Notable water loss due to moisture diffusion was recorded at 20%/day in pine and 6%/day in oak. Durability assessments through DMA and SEM analyses confirmed the suitability of wood as a container material, emphasizing the dual environmental and economic benefits of this WML-MFC design.
Understanding the evolution of China’s approach to digital trade: interests, ideas, and institutions
Authors: Zhang Danni
Published: May 2024

Amid economic globalisation and the rapid development of advanced technologies in recent years, the world economy has shown an increasing trend of digitalisation, whilst digital trade has become the primary pattern of international trade. Based on differences rooted in socio-political systems, as well as the current precarious geopolitical realities, governments adopt different ideas in accordance with their respective interests in the institutionalisation of digital trade. As the world’s second-largest economy and a major digital power, China’s behaviours and ideological stances attract scholarly attention and states’ concern. Whilst Western countries and scholars have criticised China’s ideas of “government intervention in data regulation” and “cyber sovereignty” applied in its existing approach to digital trade, warning that China’s approach poses a threat to Western powers’ adherence to liberalism in the international digital trade system and the idea of “free data flow” in their approaches to digital trade, there has been insufficient research into how China’s approach to digital trade has evolved over time and which ideas and interests have influenced it. To bridge this gap in the literature, this paper divides the evolution of China’s approach to digital trade over the past three decades (1993–2023) into three phases using a longitudinal approach. This research conducts qualitative content analysis using official documents, white papers, and declarations from official Chinese websites, then adopts the 3I analytical framework to analyse which ideas and interests have influenced China’s approach in each phase and how its approach to digital trade has evolved over time.
Thin-film flow between a rotating sphere and a nearly vertical moving plate
Authors: Ockendon H. , Ockendon J.R. , Mullin T.
Published: May 2024

When a sphere rotates near a rigid boundary coated with a thin layer of viscous liquid, ‘tracks’ are generated both behind and over the sphere. This paper describes a theory for the simplest one-track configuration which can occur under particular experimental conditions. The theoretical predictions are in good agreement with experimental observations.
Distribution in homology classes and discrete fractal dimension
Authors: Everitt James , Sharp Richard
Published: May 2024

In this note, we examine the proportion of periodic orbits of Anosov flows that lie in an infinite zero density subset of the first homology group. We show that on a logarithmic scale we get convergence to a discrete fractal dimension.
Accuracy of elastography versus biopsy in assessing severity of liver fibrosis in young Fontan patients
Authors: Bulut Ozlem P. , Bailey Smita S. , Bhat Deepti P.
Published: May 2024

Objectives:

We performed a single-centre retrospective study comparing the accuracy of non-invasive elastography with liver biopsy in accurate assessment of Fontan-associated liver disease.

Methods:

Fontan patients who underwent combined assessment with a percutaneous liver biopsy and non-invasive elastography between January 2015 and December 2023 at our Children’s hospital were included. Liver biopsies were classified using the Congestive Hepatic Fibrosis Score as early Fontan-associated liver disease (scores 1, 2) and advanced Fontan-associated liver disease (score 3/bridging fibrosis and score 4/cirrhosis). Elastography values were categorised as advanced Fontan-associated liver disease for liver elasticity >2.1 m/s by ultrasound and liver stiffness >5 KPa on magnetic resonance elastography.

Results:

We included 130 patients (116 children, 89%, mean age at biopsy: 14.6 years ± 3.6) who underwent liver biopsy at a mean duration of 11.1 years (±0.3) following Fontan surgery. Advanced Fontan-associated liver disease was noted in 41 (31.5%) patients with 13 (10%) showing frank cirrhosis. Pre-biopsy ultrasound showed advanced liver fibrosis in 18/125 (14%), with low sensitivity (23%), high specificity (90%), and low accuracy (68%, k = 0.1) in diagnosing advanced Fontan-associated liver disease. Similarly, pre-biopsy magnetic resonance elastography showed advanced fibrosis in 23/86 (27%) of patients, with low sensitivity (30%), fair specificity (75%), and low accuracy (63%, k = 0.1). Interestingly, advanced Fontan-associated liver disease was missed by ultrasound in 29% and by magnetic resonance elastography in 25% of patients. Advanced Fontan-associated liver disease was associated with lower platelet count (p = 0.02) and higher Gamma-glutamyl Transferase levels (p = 0.02).

Conclusion:

Advanced hepatic fibrosis is common among paediatric Fontan patients. Non-invasive elastography may overestimate and underestimate the degree of liver fibrosis, and therefore, liver biopsy may be required for confirming disease severity.
A Superposed Epoch Analysis of Auroral Oval Coverage During Substorms Using Deep Learning‐Based Segmentation Models
Authors: Jiang Jia‐Nan , Zou Zi‐Ming , Lu Yang , Zhong Jia , Wang Yong , Ma Yu‐Zhang , Zhao Bian‐Long
Published: May 2024

As an effect of solar‐terrestrial activity, the aurora has always been a focus of substorm research. The expansion of the aurora is one of the important characteristics during substorms, which could be directly reflected by the change of auroral oval coverage. However, the related studies were limited because of the absence of a reliable automated method to obtain auroral ovals from a large number of images. In this paper, we propose a new strategy to achieve this. Based on the Segment Anything Model, we design a process for annotating the auroral oval region that requires little manual work. A new aurora segmentation model, HrSeg, is then developed to obtain auroral ovals more efficiently and accurately. Through 5‐fold cross‐validation, it is determined that the average intersection over union, Dice coefficient, and pixel accuracy are all greater than 0.97. Furthermore, images of 590 substorms observed by the Polar satellite Ultraviolet Imager are segmented. We present superposed epoch analyses of the auroral oval coverage calculated from the segmentation results. Generally, the coverage decreases slightly before onset, then rapidly increases for tens of minutes after onset, and finally decreases gradually. Moreover, the auroras in different magnetic local time (MLT) sectors exhibit different evolutions in coverage. It is also revealed that the evolution pattern of auroral coverage depends on interplanetary magnetic field orientations and seasonal conditions. The results quantify the variation of auroral morphology in terms of coverage, which complete the evolution pattern of aurora during substorms and provide a more comprehensive understanding of substorms.
Parental conflict driven regulation of endosperm cellularization by a family of Auxin Response Factors
Authors: Butel N. , Qiu Y. , Xu W. , Santos-González J. , Köhler C.
Published: May 2024

The endosperm is a reproductive tissue supporting embryo development. In most flowering plants, the initial divisions of endosperm nuclei are not succeeded by cellularization; this process occurs only after a specific number of mitotic cycles have taken place. The timing of cellularization significantly influences seed viability and size. Previous research implicated auxin as a key factor in initiating nuclear divisions and determining the timing of cellularization. Here we uncover the involvement of a family of clustered auxin response factors (cARFs) as dosage-sensitive regulators of endosperm cellularization. cARFs, maternally expressed and paternally silenced, are shown to induce cellularization, thereby restricting seed growth. Our findings align with the predictions of the parental conflict theory, suggesting that cARFs represent major molecular targets in this conflict. We further demonstrate a recurring amplification of cARFs in the Brassicaceae, suggesting an evolutionary response to parental conflict by reinforcing maternal control over endosperm cellularization. Our study highlights that antagonistic parental control on endosperm cellularization converges on auxin biosynthesis and signalling.
Overexpression of COL11A1 confers tamoxifen resistance in breast cancer
Authors: Fu Chengxiao , Duan Shan , Zhou Xiaoming , Meng Yingcai , Chen Xisha
Published: May 2024

Breast cancer is the most commonly diagnosed malignancy and benefits from endocrine agents such as tamoxifen. However, the development of drug resistance in cancerous cells often leads to recurrence, thus limiting the therapeutic benefit. Identification of potential biomarkers that can predict response to tamoxifen and recognize patients who will clinically benefit from this therapy is urgently needed. In this study, we report that high collagen type XI alpha 1 (COL11A1) expression was associated with poor therapeutic response and prognosis in breast cancer patients treated with tamoxifen. To confirm the role of COL11A1 in the development of tamoxifen resistance, we established MCF-7/COL11A1 and T47D/COL11A1 cell lines, which stably expressed COL11A1. Compared with parental MCF-7 and T47D, MCF-7/COL11A1 and T47D/COL11A1 cells were more resistant to 4-OHT-induced growth inhibition. Moreover, the level of COL11A1 expression was upregulated in tamoxifen-resistant MCF-7/TamR and T47D/TamR cell lines, and depletion of COL11A1 markedly sensitized the cells to 4-OHT in vitro and in vivo. Interestingly, the level of estrogen receptor α (ERα) expression was elevated, probably due to the increased COL11A1 in TamR cells. In addition, knockdown of COL11A1 decreased the expression of ERα and its downstream target genes. Overall, our findings suggest that overexpressed COL11A1 contributes to tamoxifen resistance, and targeting COL11A1 holds great promise for reversing endocrine resistance.