bluuebunny/crossref_metadata_2025 huggingface dataset:
Decursin inhibits the oxidation of low-density lipoprotein and protects human aortic endothelial cells against oxidative damage
Authors: Wang Xueting , Yu Jing , Ji Binlong , Yang Yuling
Published: June 2020

Atherosclerosis is the pathological basis of cardiovascular diseases (CVDs) which are the leading cause of death worldwide. The pathogenesis of atherosclerosis itself is complex. Low-density lipoprotein (LDL) oxidation has been shown to increase lipid peroxide levels in arterial wall of atherosclerosis lesion site. Decursin is a coumarin with a range of pharmacological effects. The present study investigated the inhibitory effect of decursin on LDL oxidation, and its protective effect against oxidative damage in human aortic endothelial cells (HAECs). Two models of oxidative damage were used in this study: Cu2+-induced LDL oxidative damage and 2,2'-azobis-2-methyl-propanimidyl, dihydrochloride (AAPH)-induced oxidative damage of HAECs. The inhibitory effect of decursin on LDL oxidation, and its protective effect on oxidative damage of HAECs were determined. The results showed that the level of thiobarbituric acid reactive substances (TBARS) was significantly increased by Cu2+, but was significantly and concentration-dependently reduced after treatment with decursin (p < 0.05). There were only a few viable cells in AAPH-treated group, but treatment with decursin led to significant, time- and concentration-dependent increases in their viability (p < 0.05). The AAPH-induced oxidative damage significantly increased the activity of lactate dehydrogenase (LDH) and level of reactive oxygen species (ROS), but significantly reduced the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) (p < 0.05). However, treatment of HAECs with decursin significantly and concentration-dependently reduced the LDH activity and level of ROS, but significantly increased the activities of SOD and GPx, concentration-dependently (p < 0.05). It also significantly and concentration-dependently reduced apoptosis induced by AAPH (p < 0.05). These results show that decursin effectively inhibits LDL oxidation induced by Cu2+, and protects HAECs from oxidative damage caused by AAPH in vitro via a mechanism involving activation of SOD and GPx.
TRAIL mediated signaling as a double-edged sword in pancreatic cancer: Analysis of brighter and darker sides of the pathway
Authors: Farooqi Ammad Ahmad , Zahid Rabbia , Maryam Areesha , Naureen Humaira , Attar Rukset , Sabitaliyevich Uteuliyev Yerzhan , Konysbayevna Konysbayeva Kenzhekul
Published: June 2020

Genetic, genomic and proteomic studies have refined our concepts related to underlying mechanisms of pancreatic cancer. Increasingly sophisticated knowledge has started to shed light on the fact that pancreatic cancer harbored multiple epigenetic and genetic alterations and revealed complicated and dense tumor microenvironments. Our rapidly evolving knowledge about pancreatic cancer has helped us in identification of myriad of underlying mechanisms which play instrumental role in disease onset, drug resistance and epithelial to mesenchymal transition (EMT). Additionally, loss of apoptosis is the cornerstone of cancer biology and researchers have devoted considerable attention to the versatile regulators involved in loss and restoration of apoptosis. Discovery of TNF/TNFR, FasL/Fas and TRAIL/TRAIL-R opened new horizons for detailed analysis of intracellular mechanisms regulated by these pro-apoptotic molecules. Decades of cutting-edge research helped in translation of TRAIL-based therapeutics into clinically effective therapeutics. In this review, we will focus specifically on groundbreaking achievements which have leveraged our concepts related to TRAIL-mediated signaling to yet another level. We will also discuss how basic and clinical scientists are making efforts to overcome the stumbling blocks associated with efficacy of TRAIL-based therapeutics against TRAIL-resistant pancreatic cancers. We partition this multi-component review into overview of the conceptual breakthroughs in regulation of TRAIL-mediated signaling in pancreatic cancers, push and pull between pro- and anti-apoptotic proteins to regulate TRAIL-mediated apoptosis and how researchers have identified different natural and synthetic molecules to restore apoptosis in TRAIL-resistant pancreatic cancer. We have also summarized how long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) regulated TRAIL-mediated apoptosis in pancreatic cancer. More importantly we will also set spotlight on the darker side of TRAIL/TRAIL-R pathway in pancreatic cancer. Circumstantial evidence highlighted cancer promoting role of TRAIL/TRAIL-R in pancreatic cancer. These diametrically opposed context-dependent roles of TRAIL-pathway are intriguing and need comprehensive research to address outstanding questions.
Uninfluenced alpha-fetoprotein and treatment of liver primary carcinoma by lobaplatin in combination with 5-fluorouracil and doxorubicin via chemoembolization and transarterial chemoembolization
Authors: Chen Yongpin , Li Weibin , Yang Qing , Chen Liang , Zeng Changjiang
Published: June 2020

Alpha-fetoprotein (AFP) is a protein encoded by the AFP gene and normally produced by the fetus. The purpose of this study is to investigate the efficacy of lobaplatin in combination with 5-fluorouracil (5-FU) and doxorubicin on AFP and treatment of primary carcinoma of the liver by transhepatic arterial chemotherapy and embolization (TACE). Patients with primary carcinoma of the liver who took the TACE for treatment were enrolled in this study and divided randomly into the research group and the control group. Patients in the research group adopted the TACE in combination with lobaplatin, while those in the control group took cisplatin instead in combination with TACE. We compared the baseline data, hepatic indicators before treatment and after 1 month of treatment, efficacy and the incidence rates of adverse events after TACE between two groups. Differences in the baseline data, including Child-pugh grade, type of liver cirrhosis, KPS scores and AFP showed no statistical significance (P >0.05). Before the treatment, we identified no significant differences in the comparison of ALT, AST, TBiL and ALB between two groups (P >0.05), while significant differences emerged after treatment (P <0.05). Also, efficacy comparison revealed the significant difference between the two groups (P <0.05). After TACE, patients in the research group reported 1 case of nausea, 1 of vomiting and 1 of necrotic absorption fever, and those in the control group reported 3 cases of nausea, 5 of vomiting and 4 of necrotic absorption fever, with a significant difference in comparison of the incidence rates (P <0.05). TACE is a promising strategy for the treatment of primary carcinoma of the liver, while lobaplatin, as the 3rd generation of anti-tumor platinum-based drugs, is less toxic than cisplatin, but excels in efficacy.
Influence of inoculation with Lactobacillus on fermentation, production of 1,2-propanediol and 1-propanol as well as Maize silage aerobic stability
Authors: Selwet Marek
Published: June 2020

The aim of this study is to determine the influence of a commercial bacterial inoculant (L1) and a preparation (L2) containing threeLactobacillusstrains capable of producing 1,2-propanediol and short-chain fatty acids on maize silage aerobic stability improvement. The research showed that during 90-day ensilage, the applied preparations significantly reduced the content of DM, water-soluble carbohydrates (WSCs), pH and DM recovery (P< 0.05). The concentration of lactic acid (LA), acetic acid (AA) and propionic acid (PA) in the inoculated samples increased significantly (P< 0.05). 1,2-Propandiol and 1-propanol were not found in control silages (without additives). The addition of L1 and L2 significantly (P< 0.05) increased the concentration of these substances. The L1 and L2 mixtures significantly extended (P< 0.05) the silage aerobic stability.
Auf der Suche nach dem verlorenen Sinn? Unternehmer zwischen Gottesfurcht und Marktglaube im modernen Kapitalismus
Authors: Lutz Martin , Gehlen Boris
Published: June 2020

This issue takes a critical look at the secularity of the modern businessman as frequently postulated in research. For this purpose, the contributions examine the contingency management and interpretation of meaning on the part of both genuinely religious and non-religious businesspeople. How, and with which references, symbolisms and semantics, did businesspeople justify their actions and give them meaning? While some legitimised their actions by grounding these in religious belief, for others a belief in the market’s productive forces offered a preferable interpretation. In both cases, the actors constructed their respective "promises of salvation" in a similar way, attempting to give their actions meaning and eliminate self-doubt through ostentatious, ritualized and symbolic communication. This special issue ties in with current discussions in social science and history about the relationship between religion and the economy. By drawing on cultural historical approaches, it offers new insights into the legitimation of entrepreneurial action in modern capitalism.
Gott, Natur, Markt
Authors: Catherine Davies H.
Published: June 2020

The article compares the semantics of economic crises in the second half of the 19th century, focussing on the German-speaking world during the crises of 1857 and 1873. It examines, firstly, religious interpretations of the crises, arguing that these were on the wane. Even during the earlier crisis of 1857 they only played a role in a few instances. Secondly, the article examines the semantics employed by entrepreneurs, as found in annual reports by chambers of commerce. During both crises, the authors of these reports criticized the misdeeds of individual entrepreneurs. In 1857/58, this co-existed with the use of metaphors of physiology and meteorology. In the 1870s, by contrast, such metaphors were less frequent.
Quasi-subfield Polynomials and the Elliptic Curve Discrete Logarithm Problem
Authors: Huang Ming-Deh , Kosters Michiel , Petit Christophe , Yeo Sze Ling , Yun Yang
Published: June 2020

We initiate the study of a new class of polynomials which we call quasi-subfield polynomials. First, we show that this class of polynomials could lead to more efficient attacks for the elliptic curve discrete logarithm problem via the index calculus approach. Specifically, we use these polynomials to construct factor bases for the index calculus approach and we provide explicit complexity bounds. Next, we investigate the existence of quasi-subfield polynomials.
A signature scheme from the finite field isomorphism problem
Authors: Hoffstein Jeffrey , Silverman Joseph H. , Whyte William , Zhang Zhenfei
Published: June 2020

In a recent paper the authors and their collaborators proposed a new hard problem, called the finite field isomorphism problem, and they used it to construct a fully homomorphic encryption scheme. In this paper, we investigate how one might build a digital signature scheme from this new problem. Intuitively, the hidden field isomorphism allows us to convert short vectors in the underlying lattice of one field into generic looking vectors in an isomorphic field.
Flattening NTRU for Evaluation Key Free Homomorphic Encryption
Authors: Doröz Yarkın , Sunar Berk
Published: June 2020

We propose a new FHE scheme F-NTRU that adopts the flattening technique proposed in GSW to derive an NTRU based scheme that (similar to GSW) does not require evaluation keys or key switching. Our scheme eliminates the decision small polynomial ratio assumption but relies only on the standard R-LWE assumption. It uses wide key distributions, and hence is immune to Subfield Lattice Attack. In practice, our scheme achieves competitive timings compared to the existing schemes. We are able to compute a homomorphic multiplication in 24.4 msec and 76.0 msec for 5 and 30 levels, respectively, without amortization. Furthermore, our scheme features small ciphertexts, e.g. 2376 KB for 30 levels. The assurance gained by using wide key distributions along with the message space flexibility of the scheme, i.e. bits, binary polynomials, and integers with a large message space, allows the use of the proposed scheme in a wide array of applications.
Efficacy of pembrolizumab for advanced/metastatic melanoma: a meta-analysis
Authors: Zhang Qi , Huo Geng-wei , Zhang Hong-zhen , Song Ying
Published: June 2020

This study evaluates the efficacy of pembrolizumab for the treatment of advanced/metastatic melanoma. The literature search was conducted in electronic databases for studies that evaluated the efficacy and safety of pembrolizumab either alone or in combination with other treatments advanced/metastatic melanoma patients. Random-effects meta-analyses were performed to achieve pooled effect sizes of response and survival rates. The overall objective response rate (ORR) was 34.2% [95% confidence interval (CI): 30.4, 38.0]. However, ORR differed with respect to the history of prior systemic therapy. ORR was lower in studies with over 50% patients with prior therapy (25.5% [22.4, 28.5]) than in studies with under 50% patients with prior therapy (40.1% [34.1, 46.1]). ORR was higher in pembrolizumab monotherapy (32.9% [28.1, 37.7]) than in pembrolizumab–ipilimumab combination (27.6% [24.0, 31.2]). Overall ORR was inversely associated with visceral metastasis and prior systemic therapy. With pembrolizumab treatment, either alone or in combination, the progression-free survival (PFS) was 5.73 months; 12-, 24-, and 60-month PFS rate were 44%, 27%, and 25%, respectively; and 12-, 24-, and 60-month overall survival rates were 65%, 50%, and 41%, respectively. The percentage of AEs that led to treatment discontinuation was 13%. Pembrolizumab monotherapy is a valuable option for the treatment of advanced/metastatic melanoma patients.
The crystal structure of 3,5-difluoroisonicotinic acid, C6H3F2NO2
Authors: Zeng Yan , Du Chao-Jun
Published: June 2020

C6H3F2NO2, monoclinic, P21/n (no. 14), a = 6.8050(10) Å, b = 6.8443(9) Å, c = 12.7196(14) Å, β = 94.562(4)°, V = 590.54(13) Å3, Z = 4, R
gt(F) = 0.0395, wR
ref(F
2) = 0.1038, T = 150(2) K.
Co-constructed oppositional stance and facework in an office hour interaction
Authors: Çiftçi Hatime , Vásquez Camilla
Published: June 2020

Stance plays a salient role in communicating interpersonal meaning through language use. Understanding stance as co-constructed within dialogic interaction uncovers subtleties of how interlocutors use language to express their subjectivities and thus, negotiate their interpersonal relationship. The notion of face and facework, or relational work (Locher 2004), is therefore relevant to the understanding of stance in interaction. Drawing on Du Bois’ (2007) stance triangle, our study analyzes oppositional stance in a single, extended interaction and shows how two interlocutors in an academic setting jointly construct oppositional stance, each by drawing on their own interpretations. Our analysis indicates that this co-constructed oppositional stance is enacted throughout three broader stages, which we call initiation, negotiation, and resolution. We also demonstrate that expressing oppositional stance is a complex process where interlocutors employ various discourse strategies to express pessimistic evaluation, shifting positionings, and (dis)alignment. Meanwhile, instances of oppositional stance become face-maintaining and face-challenging at different stages in which directness and indirectness are variably employed.
Balancing power and solidarity through indirectness: A case study of Russian and Kazakh meeting chairs
Authors: Kulbayeva Aisulu
Published: June 2020

The study combines Brown and Levinson’s (1987) work on politeness techniques and Tannen’s (1981, 1993) work on indirectness and power-solidarity dynamics to extend research on workplace discourse. I examine how two female Russian-speaking chairs (one of Russian and another of Kazakh origin) differently perform face-threatening acts (FTAs) of criticisms and directives during teacher meetings at a community college in Kazakhstan. Specifically, the Russian chair employs fewer politeness techniques (e. g., hedging with “please”), issuing criticisms and orders with no mitigation, thereby foregrounding the power asymmetry within the group. The lack of mitigation surfaces through explicit usage of pronouns (“I” vs. “you”); action verbs inflected for the 2nd person plural and imperative mood; words with a negative and moral connotation; and phonological modifications for emphasis. Differently, the Kazakh chair utilizes a larger number of politeness techniques, including hedging (e. g., “please”, “unfortunately”), impersonalizing negative actions (through indefinite pronouns and agentless verbs), and manipulating of tense and space. Thus, she performs indirect FTAs that highlight the solidarity aspect of group relations. I relate these findings to studies of management leadership in post-Soviet states that have revealed the tendency of Kazakh managers to use a nurturing leadership style.
Distance Matrix of a Class of Completely Positive Graphs: Determinant and Inverse
Authors: Das Joyentanuj , Jayaraman Sachindranath , Mohanty Sumit
Published: June 2020

A real symmetric matrix A is said to be completely positive if it can be written as BBt for some (not necessarily square) nonnegative matrix B. A simple graph G is called a completely positive graph if every matrix realization of G that is both nonnegative and positive semidefinite is a completely positive matrix. Our aim in this manuscript is to compute the determinant and inverse (when it exists) of the distance matrix of a class of completely positive graphs. We compute a matrix 𝒭 such that the inverse of the distance matrix of a class of completely positive graphs is expressed a linear combination of the Laplacian matrix, a rank one matrix of all ones and 𝒭. This expression is similar to the existing result for trees. We also bring out interesting spectral properties of some of the principal submatrices of 𝒭.
The Role of Consumers’ Behaviour in Applying Green Marketing: An Economic Analysis of the Non-alcoholic Beverages Industry in Kosova
Authors: Podvorica Ganimete , Ukaj Fatos
Published: June 2020

Green marketing in Kosova evolved as a means for enterprises to adjust to increased market competitiveness. The objective of the study was to identify how consumers’ environmentally friendly behaviour drove the demand for new eco-value market offerings. Concurrently, the study aimed to prove how domestic producers of non-alcoholic beverages used their capabilities to deliver new eco-value market offerings. The research is based on a survey conducted in Kosova. Analysis focused on statistical correlation testing of consumers’ green marketing awareness, behaviour toward the environment, information search, trust in advertising and labels displaying health benefits of beverages and attitudes towards a willingness to pay more for organic non-alcoholic beverages compared with non-organic ones. Significant findings were the positive influence of family and media in shaping consumers’ environmentally friendly behaviour and, in contrast, consumers’ mistrust in the marketing activities of producers as a consequence of misleading advertising.
Community Members' Pre-exposure Prophylaxis Awareness, Attitudes, and Trusted Sources for PrEP Information and Provision, Context Matters Survey, 2015–2016
Authors: Jones Jamal T. , Smith Dawn K. , Thorne Stacy L. , Wiener Jeffrey , Michaels Stuart , Gasparac Julie
Published: June 2020

Men and women of color have had low pre-exposure prophylaxis (PrEP) uptake. How one's preferred source of health information shapes attitudes toward PrEP is unclear. We conducted cross-sectional surveys to assess changes in PrEP awareness, knowledge, and attitudes, trusted sources for PrEP information, and associations between trusted source of information and PrEP knowledge and attitudes. Participants were recruited from six areas served by community health centers in Chicago, IL (two health centers); Jackson, MS; Newark, NJ; Philadelphia, PA; and Washington, D.C. during June–September 2015 (n = 160) and June–September 2016 (n = 200). Participants were Black (74%), heterosexual (81%), and largely unaware of PrEP (72%). Participants who trusted health experts and community organizations for PrEP information had lower percentages of agreeing with statements indicative of negative PrEP attitudes. Interventions that increase PrEP awareness as well as knowledge and favorable attitudes might help increase PrEP use in communities with high HIV prevalence.
Application of a Multisite Empowerment Evaluation Approach to Increase Evaluation Capacity Among HIV Services Providers: Results From Project Pride in Chicago
Authors: Beach Lauren B. , Reidy Emma , Marro Rachel , Johnson Amy K. , Lindeman Peter , Phillips Gregory , Stonehouse Patrick , Greene George J.
Published: June 2020

In 2015, the Centers for Disease Control and Prevention (CDC) funded Project PrIDE, a national initiative to implement and evaluate demonstration projects to increase PrEP uptake among HIV-negative individuals and to re-engage HIV-positive individuals in HIV care. Our team served as the Evaluation Center for Project PrIDE organizations in Chicago and used an empowerment evaluation (EE) approach to enhance evaluation capacity at these organizations. To evaluate our approach, we assessed organizations' evaluation capacity and engagement in technical assistance and capacity building activities in 2016 and 2018. Respondents who self-reported higher engagement with the Evaluation Center and who spent a greater number of hours engaged with our evaluators experienced greater increases in evaluation capacity tied to implementation of evaluation activities and technical assistance utilization. These findings demonstrate that multisite EE can be successfully applied to increase the evaluation capacity of organizations providing both HIV prevention and care services.
HIV- and Drug Use–Related Stigma and Service Provision Among Community Health Workers in Vietnam
Authors: Li Li , Lin Chunqing , Liang Li-Jung , Chen Jun , Feng Nan , Nguyen Anh Tuan
Published: June 2020

This study compared community health workers' (CHW) stigma towards people living with HIV (PLH) and people who use drugs (PWUD) and explored the relationship between stigma and CHWs' confidence level in providing HIV/drug-related services. Using two sets of identically worded questions, levels of stigma towards PWUD and PLH were measured among 120 CHW from 60 communes in Vietnam. The associations between CHWs' confidence in service provision and stigma towards PWUD and PLH were examined using a linear mixed-effects regression model. The majority of the CHW reported higher levels of stigma towards PWUD than towards PLH. Compared to the CHW reporting higher stigma towards PWUD, those with higher stigma towards PLH were significantly less confident in service provision. Social opprobrium attached to drug-using behaviors can be a major driver behind the overall HIV stigma. CHWs' fear of HIV infection should be tackled to boost their confidence in HIV/drug-related care provision.
Nomination de l'enseignant-ressource
Authors: Chatigny Éric
Published: June 2020

En 2006, l'école secondaire Curé-Mercure de Mont-Tremblant a observé un niveau de lecture et d'écriture préoccupant chez les élèves considérés comme à risques. Le coenseignement s'est imposé comme la solution pour prendre en compte les besoins d'apprentissage particuliers de ces élèves et des enseignants-ressources ont été nommés.

L’expérience a montré les bienfaits du coenseignement, tant pour les enseignants que pour les élèves. Elle a aussi révélé le niveau de compétences élevé que l'enseignant-ressource doit posséder. Enfin, elle a montré que le processus de leur nomination doit favoriser l'engagement des enseignants et être axé sur les besoins de l'élève.
Notre expérience en coenseignement
Authors: Jeannotte Julie , Gray Nadia
Published: June 2020

Nous présentons, dans cet article, notre expérience de coenseignement du français à des groupes d'élèves à risque de l'école Louis-Philippe-Paré (Châteauguay). Nous décrivons les outils, les mesures et les méthodes de travail que nous avons jugées efficaces pour soutenir les élèves. Nous évoquons également les conditions à réunir pour une saine collaboration entre coenseignants, et formulons quelques souhaits et recommandations afin d'optimiser cette méthode d'enseignement.
Características de la canal y de la carne de corderos de un sistema intensivo
Authors: Desdémona Martínez Esmeralda
Published: June 2020

El objetivo de este trabajo es determinar las características de la canal y de la carne de corderos de diferentes fenotipos. Blackbelly (BB; n=22), Pelibuey Blanco (PB; n=16), Pelibuey Canelo (PC; n=22), Dorper (DO; n=37), Katahdin (KA; n=29), Pelibuey x Katahdin (PK; n=8) y Media Lana (ML; n=11), con un rango de edad entre 6 a 8 meses y criados en un sistema de finalización intensivo por 90 d. Las variables evaluadas en la canal son: rendimiento (REND), conformación (CONF), cobertura de grasa en la canal (CG), medidas morfométricas, color de la grasa de cobertura (CGC) y color de la carne (CC). Los datos se analizan bajo un modelo de comparación de medias. Los DO, ML y KA tuvieron mejor relación en la estructura esquelética y crecimiento de los músculos y CG (P<0,05), que los PB, PC y BB, con menor peso al sacrificio y CG. Las medidas morfométricas de la canal muestran que, los DO y ML son compactas y gruesas, resultado de la madurez temprana en la estructura esquelética, en comparación a los BB, PB y PK, que son más largas y tuvieron menor compacidad de la canal. Los DO presentaron un color de grasa blanca a cremosa y los BB y ML de blanca a amarilla. Los PB y DO tuvieron un color de la carne rojizo rosado y los PK rojo intenso. En conclusión, la madurez fisiológica de los diferentes fenotipos de corderos se reflejó en el REND, CONF, medidas morfométricas y CG. Por otra parte, las características propias del sistema de alimentación reflejaron variación en el CGC.
Reporte de caso clínico Primer diagnóstico de Rhodococcus equi confirmado, laboratorialmente, en un potrillo de Costa Rica
Authors: Estrada Roberto , Murillo Carla , Razquin Patricio , Barquero-Calvo Elías , Chacón-Díaz Carlos , Estrada Manuel
Published: June 2020

Neumonía por Rhodococcus equi es importante causa de morbilidad y mortalidad en potrillos de todo el mundo. La prevalencia y/o virulencia de la bacteria es, aparentemente, baja en Costa Rica, pues nunca han sido reportados brotes. Los casos sospechosos muestran solamente signos clínicos de leves a moderados. Sin embargo, un diagnóstico definitivo de la enfermedad nunca ha sido hecho anteriormente en caballos costarricenses. R. equi es una bacteria G (+) facultativa intracelular que causa neumonía en potrillos jóvenes (hasta 4-5 meses de edad). Este caso corresponde a un potrillo Frisón de cuatro semanas de edad que fue referido para cirugía al Hospital Equino, Universidad Nacional de Costa Rica, con una fractura de húmero y onfaloflebitis. En el período postoperatorio, el paciente presentó: signos de secreción nasal bilateral moderada, tos, fiebre, linfocitosis y neutrofilia. La evaluación radiológica del tórax mostró un patrón bronquialveolar en el aspecto ventrocraneal de los pulmones. La citología del aspirado transtraqueal confirmó un cuadro de bronconeumonía supurativa. Las muestras fueron cultivadas aeróbicamente en agar Columbia + 5% sangre a 37°C por 24h. Las características macroscópicas, microscópicas, bioquímicas y la identificación, por medio de la secuenciación parcial del gen “16SrRNA”, de la bacteria aislada fueron compatibles con R. equi. El potrillo fue eutanasiado debido a re-fractura del húmero antes de que el diagnóstico de R. equi fuera confirmado. R. equi tiene el potencial de causar un severo impacto monetario a la industria de cría equina, por lo cual, es importante hacer el diagnóstico y tratamiento precisos para evitar el surgimiento de cepas resistentes. Son necesarios más estudios para determinar la prevalencia local del patógeno y evaluar su impacto.
Perspectiva de la historia de las relaciones internacionales de la escuela española:
Authors: Sánchez Soto Roger Alfonso
Published: June 2020

Las Relaciones Internacionales son una disciplina científica que, como otras de las ciencias sociales, también encuentran apoyo en lo multidisciplinario; la obra liderada por el profesor en historia contemporánea de la Universidad Autónoma de Madrid, José Luis Neila, es un ejemplo de ello. La publicación se concibe como un producto de la escuela española de la “historia de las relaciones internacionales”, en la cual conceptos como sociedad, sistema y orden internacional estructuran el pensamiento.
Abipusė laparoskopinė retroperitoninė ureterokutaneostomija: nauja vezikorektalinių fistulių gydymo galimybė
Authors: Ulys Albertas , Šukys Deimantas , Skulčius Giedrius
Published: June 2020

Šis klinikinis atvejis iliustruoja vezikorektalinės fistulės sėkmingą gydymą ir baigtį, pirmą kartą atlikus abipusę laparoskopinę retroperitoninę ureterokutaneostomiją. Vezikorektalinės fistulės yra vienos iš retų, tačiau bene labiausiai pacientų gyvenimo kokybę veikiančių ligų, kurios neretai išsivysto po mažojo dubens organų vėžio kompleksinio gydymo ar lokaliai progresuojant navikiniam procesui. Tai vienos labiausiai žmogų luošinančių komplikacijų, kurių gydymas turi būti individualizuotas, reikalauja didelės skirtingų specialistų komandos patirties, tačiau neretai būna pavėluotas ir lydimas dažno ligos atsinaujinimo. Dėl progresuojančio onkologinio proceso ar anksčiau taikytų gydymo metodų (spindulinio, chirurginio gydymo) dažnai yra negalimos sudėtingos operacijos. Tokiu atveju gydymo sėkmę lemia pasirinkta nauja, mažiau invazyvi gydymo metodika. Šis klinikinis atvejis iliustruoja sėkmingą vezikorektalinės fistulės gydymą ir baigtį, pirmą kartą atlikus abipusę laparoskopinę retroperitoninę ureterokutaneostomiją.
9th Congress of Baltic Association of Surgeons: Abstracts (Klaipėda (Lithuania), 2018, May 10–12)
Authors: Chirurgija Lietuvos
Published: June 2020

[text in English]
Rectal Polyp Caused by Schistosoma Haematobium
Authors: Janssen Nick , Heemskerk Jeroen , Willig Arjan P. , Toebosch Susan M.
Published: June 2020

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Nonsteroidal Anti-Inammatory Drug (NSAID) – Induced Colopathy with Diaphragm-like Strictures
Authors: Magalhães Ricardo Küttner , Ferreira José Manuel , Pedroto Isabel
Published: June 2020

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Metabolic Syndrome, Insulin Resistance, Circadian Disruption, Antioxidants and Pancreatic Carcinoma: an Overview
Authors: Giudice Aldo , Crispo Anna , Massimiliano Galdiero , D’Arena Giovanni , Tecce Mario Felice , Grimaldi Maria , Amore Alfonso , Esposito Emanuela , Montella Maurizio
Published: June 2020

The incidence and number of deaths caused by pancreatic tumours have been gradually rising, while the incidence and mortality of other common cancers have been declining. Risk factors for this malignant disease include cigarette smoking, family history of chronic pancreatitis, advancing age, male sex, diabetes mellitus, obesity, non-0 blood group, a high-fat diet, alcohol consumption and possibly Helicobacter pylori and hepatitis B virus infections. Metabolic diseases have become the leading cause of death in many countries. Our paper serves as a focused and updated discussion about the development of novel preventive strategies for this deadly disease.

Abbreviations. ARE: antioxidant response element; COX-2: cyclooxygenase-2; IGFs: insulin-like growthfactors; IGF1R: IGF-1 receptor; MetS: metabolic syndrome; NAFLD: non-alcoholic fatty liver disease;NAFPD: non-alcoholic fatty pancreas disease; NASH: non-alcoholic steatohepatitis; NASP: non-alcoholic steatopancreatitis; PPARγ : peroxisome proliferator-activated receptor γ; PPARs: peroxisome proliferatoractivated receptors.
Simultaneous Occurrence of Two Rare Diseases: Actinomycosis and Melanoma of the Rectum
Authors: Dumitru Eugen , Dumitru Irina Magdalena , Popescu Razvan , Resul Ghiulendan , Bulbuc Ionut , Rugina Sorin
Published: June 2020

The simultaneous occurrence of two rare conditions in a single patient is uncommon. We report the case of a patient with rectal actinomycosis covering an anorectal melanoma (both infrequent conditions), the last one being later recognized, only after surgical excision. We underline here the role of thinking "outside the box" when an unusual situation is experienced.
Increased levels of serum amyloid A during the early phase of hepatitis C treatment with interferon are associated with sustained virologic response – a pilot study
Authors: Gschwantler Michael , Dulic Melisa , Dulic-Lakovic Emina , Schwarzer Remy , Rieder Franz , Graninger Wolfgang , Steininger Christoph
Published: June 2020

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Abnormal Liver Function Tests of Patients with Coronavirus Disease 2019 in Mainland China: A Systematic Review and Meta- Analysis
Authors: Xin Shengliang , Xu Jinghang , Yu Yanyan
Published: June 2020

Aims: Comparing the risk of abnormal liver function tests between severe and non-severe patients with coronavirus disease 2019 (COVID-19) by meta-analysis.

Methods: A literature search was conducted using the databases PubMed, Embase, and Cochrane Library. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using fixed- or random-effects models. Publication bias was detected by the Harbord test.

Results: We included 8 articles comprising 7,467 COVID-19 patients. When compared between severe and non-severe COVID-19 patients, the pooled ORs of elevated alanine aminotransferase, aspartate aminotransferase, total bilirubin, and lactate dehydrogenase levels were 2.35 (95% CI 1.38-3.98), 3.21 (95% CI 2.59-3.98), 1.87 (95% CI 1.32-2.65), and 4.83 (95% CI 2.90-8.05), respectively.

Conclusions: The severity of COVID-19 is associated with liver damage, and can be a risk factor for abnormal liver function tests.
Parental Hesitancy About Routine Childhood and Influenza Vaccinations: A National Survey
Authors: Kempe Allison , Saville Alison W. , Albertin Christina , Zimet Gregory , Breck Abigail , Helmkamp Laura , Vangala Sitaram , Dickinson L. Miriam , Rand Cindy , Humiston Sharon , Szilagyi Peter G.
Published: June 2020

BACKGROUND AND OBJECTIVES:

The World Health Organization has designated vaccine hesitancy as 1 of the 10 leading threats to global health, yet there is limited current national data on prevalence of hesitancy among US parents. Among a nationally representative sample of US parents, we aimed to (1) assess and compare prevalence of hesitancy and factors driving hesitancy for routine childhood and influenza vaccination and (2) examine associations between sociodemographic characteristics and hesitancy for routine childhood or influenza vaccination.

METHODS:

In February 2019, we surveyed families with children using the largest online panel generating representative US samples. After weighting, we assessed hesitancy using a modified 5-point Vaccine Hesitancy Scale and labeled parents as hesitant if they scored >3.

RESULTS:

A total of 2176 of 4445 parents sampled completed the survey (response rate 49%). Hesitancy prevalence was 6.1% for routine childhood and 25.8% for influenza vaccines; 12% strongly and 27% somewhat agreed they had concerns about serious side effects of both routine childhood and influenza vaccines. A total of 70% strongly agreed that routine childhood vaccines are effective versus 26% for influenza vaccine (P < .001). In multivariable models, an educational level lower than a bachelor’s degree and household income <400% of the federal poverty level predicted hesitancy about both routine childhood and influenza vaccines.

CONCLUSIONS:

Almost 1 in 15 US parents are hesitant about routine childhood vaccines, whereas >1 in 4 are hesitant about influenza vaccine. Furthermore, 1 in 8 parents are concerned about vaccine safety for both routine childhood and influenza vaccines, and only 1 in 4 believe influenza vaccine is effective. Vaccine hesitancy, particularly for influenza vaccine, is prevalent in the United States.
Contemporary Cardiac MRI in Chronic Coronary Artery Disease
Authors: Kolentinis Michalis , Le Melanie , Nagel Eike , Puntmann Valentina O
Published: June 2020

Chronic coronary artery disease remains an unconquered clinical problem, affecting an increasing number of people worldwide. Despite the improved understanding of the disease development, the implementation of the many advances in diagnosis and therapy is lacking. Many clinicians continue to rely on patient’s symptoms and diagnostic methods, which do not enable optimal clinical decisions. For example, echocardiography and invasive coronary catheterisation remain the mainstay investigations for stable angina patients in many places, despite the evidence on their limitations and availability of better diagnostic options. Cardiac MRI is a powerful diagnostic method, supporting robust measurements of crucial markers of cardiac structure and function, myocardial perfusion and scar, as well as providing detailed insight into myocardial tissue. Accurate and informative diagnostic readouts can help with guiding therapy, monitoring disease progress and tailoring the response to treatment. In this article, the authors outline the evidence supporting the state-of-art applications based on cardiovascular magnetic resonance, allowing the clinician optimal use of this insightful diagnostic method in everyday clinical practice.
Ichthyofauna of the ribeirão Sucuri, tributary of rio Tietê, upper rio Paraná basin, southeastern Brazil
Authors: Reia Lais , S. da Costa e Silva Gabriel , Garcia-Ayala James R. , P. F. Vicensotto Ana Maria , Benine Ricardo C.
Published: June 2020

The ribeirão Sucuri, a tributary of the rio Tietê, and part of the upper rio Paraná basin, is located in the municipality of Pongaí, São Paulo state. The ichthyofauna of ribeirão Sucuri was sampled at nine collection sites in May 2018. Our study captured 408 specimens representing five orders, 11 families, and 35 species. Among the species collected, two have not been previously reported from the rio Tietê basin: Eigenmannia guairaca Peixoto, Dutra & Wosiacki, 2015 and Hoplias misionera Rosso, Mabragaña, González-Castro, Delpiani, Avigliano, Schenone & Días de Astarloa, 2016. Additionally, four species were found that are non-native: Hoplias misionera, Poecilia reticulata Peters, 1859, Roeboides descalvadensis Fowler, 1932, and Satanoperca sp. This study represents the first fish inventory of a tributary on the left margin of the Tietê-Batalha sub-basin and only the second for this portion of the rio Tietê. Our results increase to 55 the number of species recorded from this sub-basin and add data on the putative morphological variation in several species.
Karakteristik Massa Air di Perairan Barat Daya Pulau Sumba, Provinsi Nusa Tenggara Timur
Authors: Tanto Try Al
Published: June 2020

Karakteristik massa air dan percampurannya dapat dipengaruhi oleh angin dan aliran air laut ke lokasi tersebut. Massa air laut terbentuk dari komposisi suhu, salinitas, dan densitas pada kedalaman tertentu. Kajian massa air pada perairan barat daya P. Sumba dilakukan menggunakan data hasil reanalysis (karakteristik massa air) seluruh lautan dunia (World Ocean Atlas 2013). Pengolahan data dilakukan berupa sebaran menegak dan melintang suhu dan salinitas, serta menentukan karakteristik massa air. Kisaran suhu perairan P. Sumba musim timur tergolong rendah, SPL berkisar 26.4 - 26.49 oC dan secara umum dari permukaan hingga dasar dengan rentang suhu 26.49 - 3.4 oC. Lapisan termoklin terjadi pada kedalaman 59.67 - 259.38 m dengan kisaran suhu 25.13 - 12.2 oC. Kisaran salinitas permukaan laut dari pantai menuju laut lepas sebesar 34.0498 - 34.1117 psu, dan nilai salinitas secara menegak adalah 34.0498 - 34.7 psu, salinitas maksimum terjadi pada perairan laut lepas, terjadi pada kedalaman dekat termoklin. Pergerakan massa air permukaan pada musim timur diperkirakan akibat angin muson tenggara. Karakteristik massa air yang terdapat ada perairan P. Sumba diperkirakan adalah North Pacific Subtropical Water yang terjadi dekat lapisan termoklin, dengan salinitas 34.55 - 34.7 psu, suhu 12 - 15°C, dan densitas 25.5 - 26. Pada lapisan dalam juga diduga terdapat massa air Indonesian Intermediate Water (IIW), dengan salinitas 34.6 - 34.7 psu, suhu 3 - 7 oC, dan densitas 27 - 27.7.
Apresentação DOSSIÊ “EDUCAÇÃO, CULTURA E RELIGIÃO
Authors: Pinheiro dos Santos Naira , Feitosa Coelho Fernanda Marina
Published: June 2020

O dossiê “Educação, cultura e religião” contempla artigos que analisam, em perspectiva de gênero, imbricamentos entre educação, cultura e religião, seus desdobramentos, consequências e resistências no ambiente educacional, quer no Brasil como em outros países.
A teocratização, privatização e militarização no Governo Bolsonaro: perspectivas anti democráticas e contrárias à educação
Authors: Franco Clarissa De , Maranhão Filho Eduardo Meinberg de Albuquerque
Published: June 2020

neste âmbito de militarização do governo, nunca é tarde para lembrar que o governo tem suas armas ideológicas: as notícias falsas (ou fake news), utilizadas desde a campanha de Bolsonaro à Presidência da República (Eduardo MARANHÃO F°., Fernanda COELHO e Tainah Biela DIAS, 2018). Dentre elas, se destaca o combate à ideologia de gênero, que se ampara na ideologia de gênesis e dispositivo da cis-heteronorma que, como sinalizado acima, relacionam-se especialmente ao contexto de teocratização do atual governo.
Santas, condenadas ou demoníacas? Mulheres no imaginário do Além-Mundo no Cristianismo Primitivo
Authors: Mattos Carlos Eduardo De Araújo de , Nogueira Paulo Augusto de Souza
Published: June 2020

Este artigo surge a partir de debates sobre a religião de mulheres no Cristianismo Primitivo. Enquanto se discute o papel de lideranças, apóstolas e mulheres mártires, optamos por enfatizar a presença feminina no Além-Mundo. Após apresentar a fonte e alguns comentários explicativos da mesma, destaco nela (Apocalipse de Paulo) como as mulheres consideradas pecadoras condenadas ao Inferno são retratadas e por quais pecados são punidas. Posteriormente, a partir de uma hermenêutica feminista de Tina Pippin, discuto o tema do tratamento geral que é dado às mulheres na literatura apocalíptica.
Tindak Pidana Penganiayaan dalam Fiqh Jinayah dan Hukum Pidana Indonesia
Authors: Wahyudi Eko
Published: June 2020

Often the violence perpetrated by a group of people against suspected perpetrators of certain acts of crime, sometimes even people doing things that are beyond the boundaries of humanity, called "citizen vigilantism". This paper is a description of the persecution in fiqh jinayah and positive criminal law. The conclusion of this paper is that in fiqh jinayah persecution consists of (1) due to deliberate and (2) due to negligence, whose object consists of: (1) regarding parts of the human body, (2) removes the meaning of limbs, wounds on the head, (4) injuries to other limbs, and (5) other injuries, while the punishment is qisas, if forgiven then replaced diyah, and if forgiven then replaced ta'zir. Whereas in the Indonesian Penal Code, persecution consists of due to "deliberate" or "negligence", which is divided into (1) ordinary abuse, (2) minor persecution, (3) plain old-planned persecution, (4) severe persecution and (5) persecution weight with a planned first.
Analisis Strategi Pemasaran Simpanan dan Pembiayaan di KJKS Manfaat Surabaya
Authors: Achmad Zainul Muhaimin
Published: June 2020

Become a new paradigm for achieving marketing success that is by establishing and maintaining relationships with consumers on an ongoing basis, which is called the marketing strategy. Likewise with KJKS Benefits of Surabaya. Finally the conclusion of this paper is, that: first the role of marketing KJKS Benefits of Surabaya in an effort to introduce savings and financing products to consumers is very important and also become one of the success of a company to earn profits, for the development of its products, for the continuity of its business, and for business continuity, KJKS Benefits of conducting marketing activities in the form of Advertising, Marketing, Publicity, Individual Sales, and Direct Sales. Second, the marketing strategy carried out by KJKS Benefit Surabaya in an effort to introduce and market savings and financing products is to establish cooperation with members who work with KJKS Benefit Surabaya, through print media, advertisements, exhibitions and through general trends that are currently considered to be very easy and practical in conveying information about a product by marketers both Cooperatives and other business companies, namely through the Social Media network.
Pornografi Ditinjau dari Hukum Positif dan Hukum Pidana Islam
Authors: Ummah Siti Risdatul
Published: June 2020

Pada masa sekarang perkembangan media social begitu pesatnya, yang tentunya mempengaruhi pola hidup masyarakat. Namun perkembangan ini sering disalah gunakan, salah satunya adalah cyberpor. Tulisan ini ingin mengkaji dan menganalisis pornografi dalam prespektif Hukum Pidana Indonesia dan Hukum Pidana Islam. Di akhir tulisan disimpulkan bahwa, pertama, pronografi dalam hokum pidana Indonesia didefinisikan sebagai gambar, sketsa, ilustrasi, foto, tulisan, suara, bunyi, gambar bergerak, animasi, kartun, percakapan, gerak tubuh, atau bentuk pesan lainnya melalui berbagai bentuk media komunikasi dan/atau pertunjukan di muka umum, yang memuat kecabulan atau eksploitasi seksual yang melanggar norma kesusilaan dalam masyarakat. Pengaturannya terdapat dalam KUHP (Pasal 282), dalam Undang-undang Nomor 44 Tahun 2008 tentang Pornografi, dan dalam Undang-undang Nomor 11 Tahun 2008 Tentang Informasi dan Transaksi Elektronik. Kedua, bahwa pornografi dalam Hukum Islam termasuk zina yang tidak sampai terkena hukuman (hadd), namun tetap membuat pelakunya berdosa. Sanksi bagi pelaku pornografi adalah taâ€™zir, yang penetapan kadar sanksi merupakan hak bagi pemimpin negara sesuai dengan tingkat kejahatan yang dilakukan.
Filsafat Kewarisan dalam Hukum Islam
Authors: Musyafa'ah NurLailatul
Published: June 2020

Salah satu peristiwa penting yang dialami oleh manusia adalah kematian, yaitu proses akhir dari kehidupan manusia. Karena merupakan peristiwa hokum, kematian tersebut malahirkan akibat hokum, yaitu hukum waris, yaitu beralihnya harta yang ditinggalkan orang yang mati kepada ahli waris. Dalam hokum Islam, hukum kewarisan adalah hukum yang mengatur segala sesuatu yang berkenaan dengan peralihan hak dan atau kewajiban atas harta kekayaan seseorang setelah ia meninggal dunia kepada ahli warisnya. Dalam hokum waris Islam terdapat enam asas, yaitu (1) asas ijbary, (2) asas waratha, (3) asas thuluthay al-mal, (4) asas bilateral, (5) asas keadilan atau keseimbangan, dan (6) asas individual. Sedangkan dalam pewarisan Islam di Indonesia terdapat tiga asas yang dianut, sebagaimana dalam Kompilasi Hukum Islam, yaitu: (1) asas ijbary, (2) asas waratsa, dan (3) asas bilateral.
Etika Distribusi Dalam Ekonomi Islam
Authors: Syihabuddin Atok
Published: June 2020

Manusia berinteraksi dengan manusia lainnya untuk saling bertukar potensi, yang tujuannya agar tercipta interaksi yang lebih beragam. Dalam interaksi ini terkadang manusia menjadi pemangsa bagi manusia yang lain. Dalam kondisi seperti ini Islam hadir untuk memberikan batasan-batasannya, berupa kabar, perintah, dan larangan. Salah satu larangan dalam al-Qurâ€™an adalah berputar dan beredarnya kekayaan hanya pada orang-orang yang kaya saja, sehingga perlu adalam distribusi kekayaan yang adil. Pembahasan dalam tulisan ini diawali dengan pembahasan tentang distribusi dan etikanya, sehingga memunculkan berbagai konsep aksioma etika dari beberapa pendapat Ekonom Muslim. Sistem ekonomi Islam berangkat dari kesadaran tentang etika, yang berbeda dengan sistem ekonomi yang lain. Selanjutnya diuraikan filantropi Islam sebagai wujud dari aksiologi etika distribusi, baik filantropis wajib maupun sunnah. Melalui ajaran filantropi ini, Islam ingin mereduksi sifat negatif manusia, bahkan menjadikannya sebagai penyangga keislaman (rukun Islam). Artinya, tanpa melaksanakannya berarti keislaman seseorang akan runtuh. Ini merupakan aksilogi nyata atas etika distribusi yang digagas oleh Islam. Pelaksanaan filantropi Islam dan dibarengi dengan pengetahuan syariah merupakan langkah awal dari wujudnya kesejahtraan masyarakat.