bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Investigation of Compression Ignition Engine Combustion, Performance, and Emission Characteristics of Ternary Blends with Higher Alcohols (1-Heptanol and n-Octanol)
Authors: Thippeshnaik Ganesha , Prakash Sajjal Basanna , Suresh Ajith Bintravalli , Chandrashekarappa Manjunath Patel Gowdru , Samuel Olusegun David , Der Oguzhan , Ercetin Ali
Published: September 2023

Concerns about the depletion of petroleum reserves and rising pollution led researchers to search for alternate and environmentally compatible fuels for compression ignition engines. As an excellent alternative fuel additive to biodiesel–diesel blends, higher alcohol exhibits outstanding fuel properties (such as high energy content and cetane number) and can operate in diesel engines without requiring engine changes. This study focuses on investigating the ternary blends comprising higher alcohols, namely 1-heptanol and n-octanol, in hybrid biodiesel (animal fat oil–rice bran oil–cottonseed oil) and diesel on compression ignition engine characteristics. The performance, combustion, and emissions of a diesel engine fuelled with mono (D100), binary (B20), and ternary fuel blends (B20H10, B20H20, B20O10, and B20O20) were analysed at a constant engine speed of 1500 rpm. The test fuels met the American Society for Testing and Materials standards for fuel properties and exhibited stable behaviour during testing. Experimental results showed that at 100% load, the least brake-specific fuel consumptions for diesel fuel, B20, B20H10, B20H20, B20O10, and B20O20 were 254.1 g/kWh, 302.14 g/kWh, 281.25 g/kWh, 310.94 g/kWh, 292.8 g/kWh, and 313.80 g/kWh, respectively. Meanwhile, the maximum brake thermal efficiency values were obtained as 38.65%, 37.01%, 37.76%, 36.84%, 37.12%, and 36.38%, respectively. At 100% load, the peak heat release rates for diesel, B20, B20H10, B20H20, B20O10, and B20O20 were found to be 64.65 J/deg, 59.07 J/deg, 62.34 J/deg, 56.12 J/deg, 57.95 J/deg, and 51.9 J/deg, respectively. The addition of 1-heptanol and n-octanol as oxygenated additives into the ternary blend resulted in decreased carbon monoxide and unburned hydrocarbon emissions while increasing carbon dioxide and nitrous oxide emissions compared to diesel fuel. Overall, the study concludes that ternary blends with 1-heptanol and n-octanol as additives improve performance and combustion behaviour and reduce exhaust emissions compared to binary blends.
Assessment of Bark Properties from Various Tree Species in Terms of Its Hydrophobicity and Energy Suitability
Authors: Sobol Łukasz , Sabat Dominika , Dyjakon Arkadiusz
Published: September 2023

Wood bark is a by-product of the forestry industry with significant quantitative potential. Due to the higher heating value and hydrophobic character (dictated by the content of hydrophobic extracts in the chemical composition of the bark) facilitating long-term storage and transport, bark is considered a valuable material to be integrated into the energy industry as a substrate for combustion and co-combustion. However, the heterogeneous structure of the biomass causes significant differences in these parameters between different types of bark. For this reason, this study aimed to analyze the energy usefulness and hydrophobicity of 14 species of bark occurring in large amounts across Europe. Bark’s higher heating value has been shown to range from 17.239 MJ·kg−1 ± 0.318 MJ·kg−1 to 21.618 MJ·kg−1 ± 0.375 MJ·kg−1, and most species are extremely hydrophobic in the WDPT (water drop penetration time; 70–10,495 s) and MED (molarity ethanol droplet; 8.5–24%) tests. Nevertheless, the statistically significant differences between the species in the hydrophobicity tests indicate that the storage of individual types of bark should be adapted to the species and preceded by an analysis of its hydrophobicity. It was also shown that the WDPT test seems to be more suitable for the analysis of highly hydrophobic biomasses, due to the possibility of better differentiation of the level of hydrophobicity between species showing the same degree of hydrophobicity. In addition, the best type of bark that could be implemented in the power industry from the point of view of hydrophobicity and combustion characteristics was Silver Birch bark.
Diabetic Kidney Disease: Goals for Management, Prevention, and Awareness
Authors: Greco Callie W. , Hall Julianne M.
Published: September 2023

Diabetic kidney disease (DKD), which is diagnosed on the basis of reduced glomerular filtration rate (GFR), increased albuminuria, or both, is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide. Future projections anticipate a significant increase in diabetes cases, with close to 700 million diabetes patients internationally by the year 2045. Amidst ongoing research into novel biomarkers and therapeutic agents for DKD, the current clinical preventative strategy for DKD involves (1) intensive glycemic control, (2) treatment of associated co-morbidities (hypertension and hyperlipidemia), and (3) instruction on lifestyle modifications, including smoking cessation, exercise, and dietary habits. In addition to these three categories, patient education on renal injury, a fourth category, is equally important and necessary in the collaborative effort to reduce global rates of DKD. In this entry, authors highlight and discuss these four core categories for DKD prevention.
Setup Time Reduction of an Automotive Parts Assembly Line Using Lean Tools and Quality Tools
Authors: Oliveira Cátia , Lima Tânia M.
Published: September 2023

The business world is becoming more competitive. Therefore, it is crucial to increase the flexibility of production by decreasing the time used in the processes of preparing the production lines for new items’ production, reducing changeover and setup times. This paper presents a case study where the main goal is to reduce the setup time of welding robots. Single Minute Exchange of Die (SMED) was implemented, using other tools such as the Spaghetti Diagram, ERCS Analysis (Eliminate, Rearrange, Combine, Simplify), Gemba Walk, Standardized Work, Flowcharts, and Pareto Diagram. The setup time decreased by 36% in the welding robots studied, decreasing the motions by 43% during the changeover process and reducing the time from the categories: “transportation”, “main”, “other”, and “waiting”. In addition to SMED implementation, this study offers an integrated study of several Lean tools and Quality tools to achieve the maximum reduction of changeover and setup times.
The Relationship between Stand Structure and Tree Growth Form—Investigating the Effects of Selection Cuttings in Mountainous Mixed Beech Forests
Authors: Karamzadeh Sarkhosh , Nikooy Mehrdad , Abkenari Kambiz Taheri , Tavankar Farzam , Lo Monaco Angela , Picchio Rodolfo
Published: September 2023

Among forest management methods, selection cutting puts into practice applications that follow the processes that naturally occur in the ecosystem. The purpose of this research was to investigate the effects of selection cutting on the stand structural characteristics and growth form of trees. The effect of selection cutting was evaluated in terms of the frequency and standing volume of trees and deadwood, diversity of tree species indices, stand structural complexity index (SCI), height-to-diameter ratio (HDR) or slenderness index, and live crown ratio of trees (LCR). These were measured and estimated through a systematic random plot sampling in two adjacent parcels with different management histories (parcel A, managed using the selection cutting method, and parcel B, managed using the protected method and without cutting trees) in mixed beech forests in Northern Iran. The results showed that the standing volume, Shannon index, deadwood volume, and SCI index in parcel A were lower than in parcel B. The selection cuttings had no effect on the HDR value of the upper-storey trees, while it decreased the HDR value of the middle-storey and light-demanding trees (maple and alder) and increased the HDR value of the lower-storey and beech trees. Also, the results showed that as a result of the implementation of selection cuttings, the total LCR of the lower-storey trees increased, but the total LCR of the upper-storey trees decreased compared to the protected forest. Furthermore, the results showed that tree growth form (HDR and LCR) are related to the SCI of the stands. These results showed that the implementation of the single-selection method had simplified the structure of the stands; also, with the changes made in the growth form of trees, the possibility of snow and wind damage was increased, especially in young trees. It is necessary to prioritize the ecological values of forest deadwood, thick trees, biological diversity, and the resistance of these stands against snow and wind damage in the next cutting operations.
Linking Vegetation Diversity and Soils on Highway Slopes: A Case Study of the Zhengzhou–Xinxiang Section of the Beijing–Hong Kong–Macau Highway
Authors: Cao Wei , Zhu Niuniu , Meng Zhenyu , Lv Chenxi , Chen Yue , Wang Guojie
Published: September 2023

The rapid development of highways has caused a series of ecological problems, the restoration of which is an important part of highway construction. However, most related studies have focused only on the early stages of slope restoration. The present study investigated the Zhengzhou–Xinxiang section of the Beijing–Hong Kong–Macau Highway, which has been restored over more than 20 years, examining nine representative vegetation communities within this section and investigating their species diversity and soil physicochemical properties. Redundancy analysis and the grey correlation degree model were used to determine the relationship and coupling mechanism between vegetation diversity and soil physiochemical properties. The results showed some differences in the diversity of different vegetation communities and soil physicochemical properties; vegetation diversity was mainly influenced by organic material, total and available nitrogen, total and available phosphorus, slope, available potassium, and soil bulk density. Overall, environmental factors had a strong correlation with the Simpson dominance index and a weak correlation with the species richness index. The degree of coordination between vegetation community diversity and the soil coupling of the road slope remained on low and medium levels. Artificial vegetation restoration can regulate water and fertilizer resources and promote the restoration of highway slope vegetation.
Eucalyptus Plantation Area Extraction Based on SLPSO-RFE Feature Selection and Multi-Temporal Sentinel-1/2 Data
Authors: Lin Xiaoqi , Ren Chao , Li Yi , Yue Weiting , Liang Jieyu , Yin Anchao
Published: September 2023

An accurate and efficient estimation of eucalyptus plantation areas is of paramount significance for forestry resource management and ecological environment monitoring. Currently, combining multidimensional optical and SAR images with machine learning has become an important method for eucalyptus plantation classification, but there are still some challenges in feature selection. This study proposes a feature selection method that combines multi-temporal Sentinel-1 and Sentinel-2 data with SLPSO (social learning particle swarm optimization) and RFE (Recursive Feature Elimination), which reduces the impact of information redundancy and improves classification accuracy. Specifically, this paper first fuses multi-temporal Sentinel-1 and Sentinel-2 data, and then carries out feature selection by combining SLPSO and RFE to mitigate the effects of information redundancy. Next, based on features such as the spectrum, red-edge indices, texture characteristics, vegetation indices, and backscatter coefficients, the study employs the Simple Non-Iterative Clustering (SNIC) object-oriented method and three different types of machine-learning models: Random Forest (RF), Classification and Regression Trees (CART), and Support Vector Machines (SVM) for the extraction of eucalyptus plantation areas. Each model uses a supervised-learning method, with labeled training data guiding the classification of eucalyptus plantation regions. Lastly, to validate the efficacy of selecting multi-temporal data and the performance of the SLPSO–RFE model in classification, a comparative analysis is undertaken against the classification results derived from single-temporal data and the ReliefF–RFE feature selection scheme. The findings reveal that employing SLPSO–RFE for feature selection significantly elevates the classification precision of eucalyptus plantations across all three classifiers. The overall accuracy rates were noted at 95.48% for SVM, 96% for CART, and 97.97% for RF. When contrasted with classification outcomes from multi-temporal data and ReliefF–RFE, the overall accuracy for the trio of models saw an increase of 10%, 8%, and 8.54%, respectively. The accuracy enhancement was even more pronounced when juxtaposed with results from single-temporal data and ReliefF-RFE, at increments of 15.25%, 13.58%, and 14.54% respectively. The insights from this research carry profound theoretical implications and practical applications, particularly in identifying and extracting eucalyptus plantations leveraging multi-temporal data and feature selection.
Enhancing Methane Production through Anaerobic Co-Digestion of Sewage Sludge: A Modified ADM1 Model Approach
Authors: Mudzanani Khuthadzo E. , Phadi Terence T. , Iyuke Sunny E. , Daramola Michael O.
Published: September 2023

The International Water Association’s (IWA) established Anaerobic Digestion Model No. 1 (ADM1) was created to serve as a backup for experimental findings regarding the actual anaerobic digestion process. The previous model idea was adjusted and used to simulate an anaerobic digestion process in this study. Testing procedures, such as benchmark tests and balance checks, were performed in order to verify the accuracy of the implementation. These measures worked in tandem to ensure that the model was implemented flawlessly and without inconsistencies. The primary objective of this article is to construct a method that is based on the ADM1 for evaluating co-digestion and predicting the performance of the digestion process or methane yield based on the analyzed substrates’ physicochemical properties. Additional equations and simulations have been added to the standard model to create tools for evaluating the feasibility of anaerobic co-digestion. The study’s two most intriguing aspects are the optimal mixture and parameter dependence. The adjusted ADM1 is accurate in predicting the measured values of effluent COD, pH, methane, and produced biogas flows with a reasonable degree of accuracy, according to the validation results. This research shows how to use ADM1 in a wastewater treatment plant and other settings where anaerobic digestion is of interest.
Prediction Model of Borehole Spontaneous Combustion Based on Machine Learning and Its Application
Authors: Qi Yun , Xue Kailong , Wang Wei , Cui Xinchao , Liang Ran
Published: September 2023

In order to quickly and accurately predict borehole spontaneous combustion danger and avoid borehole spontaneous combustion fires, a borehole spontaneous combustion prediction model combining the Hunger Games search optimization algorithm (HGS) and Random Forest (RF) algorithm was introduced. The number of trees and the minimum number of leaf nodes in RF were optimized by HGS. Based on the data obtained from the temperature rise experiment of spontaneous combustion characteristics in a Shandong mine laboratory, O2, CO, C2H4, CO/∆O2 and C2H4/C2H6 were selected as the input indexes for the prediction of borehole spontaneous combustion, and the spontaneous combustion temperature was selected as the output indexes to train the built model. The prediction performance and accuracy of the model were evaluated using four indexes: the mean absolute error (MAE), mean absolute percentage error (MAPE), root mean square error (RMSE) and coefficient of determination (R2). At the same time, the prediction results of the HGS-RF model were compared with those of the RF model, Sparrow search algorithm (SSA) optimization RF model, particle swarm optimization RF model (PSO) optimization RF model and quantum particle swarm optimization RF model (QPSO) optimization. The results showed that the MAE of the RF, SSA-RF, PSO-RF, QPSO-RF and HGS-RF model samples were 17.541, 15.7752, 12.5903, 6.8594 and 6.6921, respectively. MAPE was 13.81%, 10.9766%, 9.6802%, 4.5731% and 5.1536%, respectively. RMSE values were 21.5646, 15.2017, 17.0091, 11.9879 and 12.1691, respectively. The R2 values were 0.9043, 0.9315, 0.9266, 0.9668, and 0.9717, respectively. At the same time, the reliability of the HGS-RF model was supplemented by taking the test data of the Zhengjia1204 coal mining face as an example. Finally, the model was applied to the prediction of borehole spontaneous combustion in the Jinniu Coal Mine, Shanxi Province. The prediction results show that the HGS-RF model can predict the spontaneous combustion temperature of different boreholes quickly and accurately. The results show that the HGS-RF model is more universal and stable than other models, indicating that the HGS-RF model is more suitable for the prediction of borehole spontaneous combustion.
An Automated Fire Code Compliance Checking Jointly Using Building Information Models and Natural Language Processing
Authors: Wang Yukang , Liu Yue , Cai Haozhe , Wang Jia , Zhou Xiaoping
Published: September 2023

Fire checking is indispensable for guaranteeing the fire safety of buildings as it reviews the compliance of the building with fire codes and regulations. Automated Compliance Checking (ACC) systems that check building data utilizing Building Information Modeling (BIM) against fire codes have emerged as an active field of research. Substantial efforts have focused on analyzing the properties of the building components. However, the analysis of the spatial geometric relationships of building components has received inadequate attention. The present study proposes a novel ACC system leveraging Natural Language Processing (NLP) techniques to review the spatial geometric relationships of building components in BIM models. First, a framework for a BIM-based ACC system is delineated and decomposes ACC into three constituent subtasks: building model parsing, code knowledge translation, and compliance check result reporting. Second, an approach for structured processing of spatial geometric stipulations in fire codes using NLP is presented to review the geometric relationships between components in building models. Finally, the system’s performance is assessed by testing fire code compliance across various building types utilizing BIM models. The empirical findings demonstrate that the system achieves superior recall compared with the manually formulated gold standard, with the ACC system enabling quick, accurate, and comprehensive automated compliance checking.
Characterization of Molecular Chaperone GroEL as a Potential Virulence Factor in Cronobacter sakazakii
Authors: Zhu Dongdong , Fan Yufei , Wang Xiaoyi , Li Ping , Huang Yaping , Jiao Jingbo , Zhao Chumin , Li Yue , Wang Shuo , Du Xinjun
Published: September 2023

The molecular chaperone GroEL of C. sakazakii, a highly conserved protein encoded by the gene grol, has the basic function of responding to heat shock, thus enhancing the bacterium’s adaptation to dry and high-temperature environments, which poses a threat to food safety and human health. Our previous study demonstrated that GroEL was found in the bacterial membrane fraction and caused a strong immune response in C. sakazakii. In this study, we tried to elucidate the subcellular location and virulent effects of GroEL. In live C. sakazakii cells, GroEL existed in both the soluble and insoluble fractions. To study the secretory mechanism of GroEL protein, a non-reduced Western immunoblot was used to analyze the form of the protein, and the result showed that the exported GroEL protein was mainly in monomeric form. The exported GroEL could also be located on bacterial surface. To further research the virulent effect of C. sakazakii GroEL, an indirect immunofluorescence assay was used to detect the adhesion of recombinant GroEL protein to HCT-8 cells. The results indicated that the recombinant GroEL protein could adhere to HCT-8 cells in a short period of time. The recombinant GroEL protein could activate the NF-κB signaling pathway to release more pro-inflammatory cytokines (TNF-α, IL-6 and IL-8), downregulating the expression of tight-junction proteins (claudin-1, occluding, ZO-1 and ZO-2), which collectively resulted in dose-dependent virulent effects on host cells. Inhibition of the grol gene expression resulted in a significant decrease in bacterial adhesion to and invasion of HCT-8 cells. Moreover, the deficient GroEL also caused slow growth, decreased biofilm formation, defective motility and abnormal filamentation of the bacteria. In brief, C. sakazakii GroEL was an important virulence factor. This protein was not only crucial for the physiological activity of C. sakazakii but could also be secreted to enhance the bacterium’s adhesion and invasion capabilities.
Determination of Oxygen Heterocyclic Compounds in Foods Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry
Authors: Cafeo Giovanna , Satira Antonella , Russo Marina , Mondello Monica , Dugo Paola
Published: September 2023

The aim of this research was to determine oxygen heterocyclic compounds in twenty-six Citrus- and cinnamon-flavoured foods using supercritical fluid chromatography in combination with triple-quadrupole mass spectrometry (SFC-QqQ-MS). According to the authors’ knowledge, this is the first report on the determination of these molecules in foods by means of the SFC-QqQ-MS technique. The analytical technique normally used for their determination in foods is liquid chromatography coupled with a photodiode array detector. However, supercritical fluid chromatography is proving to be a valid alternative approach to investigating coumarins, furocoumarins and polymethoxyflavones. According to the results presented herein, each sample analysed showed the presence of molecules of interest. Coumarin was found in all the cinnamon-flavoured samples analysed in a low concentration. The presence of oxygen heterocyclic compounds in all the Citrus-flavoured samples, according to the label, comfirmed that the foods selected for this research article were prepared with Citrus fruits. Among the samples analysed, mandarin juice was the richest in bioactive compounds, representing a good source of polymethoxyflavones in a diet.
Four-Dimensional (4D) Printing of Dynamic Foods—Definitions, Considerations, and Current Scientific Status
Authors: Fahmy Ahmed Raouf , Derossi Antonio , Jekle Mario
Published: September 2023

Since its conception, the application of 3D printing in the structuring of food materials has been focused on the processing of novel material formulations and customized textures for innovative food applications, such as personalized nutrition and full sensory design. The continuous evolution of the used methods, approaches, and materials has created a solid foundation for technology to process dynamic food structures. Four-dimensional food printing is an extension of 3D printing where food structures are designed and printed to perform time-dependent changes activated by internal or external stimuli. In 4D food printing, structures are engineered through material tailoring and custom designs to achieve a transformation from one configuration to another. Different engineered 4D behaviors include stimulated color change, shape morphing, and biological growth. As 4D food printing is considered an emerging application, imperatively, this article proposes new considerations and definitions in 4D food printing. Moreover, this article presents an overview of 4D food printing within the current scientific progress, status, and approaches.
Nanogel-Based Delivery System for Lemongrass Essential Oil: A Promising Approach to Overcome Antibiotic Resistance in Pseudomonas aeruginosa Infections
Authors: Aldawsari Mohammed F. , Foudah Ahmed I. , Rawat Pinki , Alam Aftab , Salkini Mohamad Ayman
Published: September 2023

The emergence of antibiotic-resistant strains of Pseudomonas aeruginosa (P. aeruginosa) presents a substantial obstacle in medical environments. To effectively tackle this problem, we suggest an innovative approach: employing a delivery system based on nanogels to administer lemongrass essential oil (LGO). Developed PVA and PLGA nanoparticle formulation efficiently encapsulates LGO with 56.23% encapsulation efficiency by solvent extraction technique, preserving stability and bioactivity. Nanogel: 116 nm size, low polydispersity (0.229), −9 mV zeta potential. The nanogel’s controlled release facilitated targeted LGO delivery via pH-controlled dissolution. Pure LGO had the highest release rate, while LGO-NP and LGO-NP-CG exhibited slower rates. In 15 h, LGO-NP released 50.65%, and LGO-NP-CG released 63.58%, releasing 61.31% and 63.58% within 24 h. LGO-NP-CG demonstrated superior antioxidant activity, a lower MIC against P. aeruginosa, and the most potent bactericidal effect compared to other formulations. This underscores the versatile efficacy of LGO, suggesting its potential to combat antibiotic resistance and enhance treatment effectiveness. Moreover, employing a nanogel-based delivery approach for LGO offers an efficient solution to combat drug resistance in P. aeruginosa infections. By employing strategies such as nanogel encapsulation and controlled release, we can enhance the effectiveness of LGO against antibiotic-resistant strains. This study establishes a robust foundation for exploring innovative approaches to treating P. aeruginosa infections using nanomedicine and paves the way for investigating novel methods of delivering antimicrobial drugs. These efforts contribute to the ongoing battle against antibiotic resistance.
Investigation of lncRNA in Bos taurus Mammary Tissue during Dry and Lactation Periods
Authors: Marceau Alexis , Wang Junjian , Iqbal Victoria , Jiang Jicai , Liu George E. , Ma Li
Published: September 2023

This study aims to collect RNA-Seq data from Bos taurus samples representing dry and lactating mammary tissue, identify lncRNA transcripts, and analyze findings for their features and functional annotation. This allows for connections to be drawn between lncRNA and the lactation process. RNA-Seq data from 103 samples of Bos taurus mammary tissue were gathered from publicly available databases (60 dry, 43 lactating). The samples were filtered to reveal 214 dry mammary lncRNA transcripts and 517 lactating mammary lncRNA transcripts. The lncRNAs met common lncRNA characteristics such as shorter length, fewer exons, lower expression levels, and less sequence conservation when compared to the genome. Interestingly, several lncRNAs showed sequence similarity to genes associated with strong hair keratin intermediate filaments. Human breast cancer research has associated strong hair keratin filaments with mammary tissue cellular resilience. The lncRNAs were also associated with several genes/proteins that linked to pregnancy using expression correlation and gene ontology. Such findings indicate that there are crucial relationships between the lncRNAs found in mammary tissue and the development of the tissue, to meet both the animal’s needs and our own production needs; these relationships should be further investigated to ensure that we continue to breed the most resilient, efficient dairy cattle.
Mapping Quantitative Trait Loci (QTLs) for Hundred-Pod and Hundred-Seed Weight under Seven Environments in a Recombinant Inbred Line Population of Cultivated Peanut (Arachis hypogaea L.)
Authors: Miao Penghui , Meng Xinhao , Li Zeren , Sun Sainan , Chen Charles Y. , Yang Xinlei
Published: September 2023

The cultivated peanut (Arachis hypogaea L.) is a significant oil and cash crop globally. Hundred-pod and -seed weight are important components for peanut yield. To unravel the genetic basis of hundred-pod weight (HPW) and hundred-seed weight (HSW), in the current study, a recombinant inbred line (RIL) population with 188 individuals was developed from a cross between JH5 (JH5, large pod and seed weight) and M130 (small pod and seed weight), and was utilized to identify QTLs for HPW and HSW. An integrated genetic linkage map was constructed by using SSR, AhTE, SRAP, TRAP and SNP markers. This map consisted of 3130 genetic markers, which were assigned to 20 chromosomes, and covered 1998.95 cM with an average distance 0.64 cM. On this basis, 31 QTLs for HPW and HSW were located on seven chromosomes, with each QTL accounting for 3.7–10.8% of phenotypic variance explained (PVE). Among these, seven QTLs were detected under multiple environments, and two major QTLs were found on B04 and B08. Notably, a QTL hotspot on chromosome A08 contained seven QTLs over a 2.74 cM genetic interval with an 0.36 Mb physical map, including 18 candidate genes. Of these, Arahy.D52S1Z, Arahy.IBM9RL, Arahy.W18Y25, Arahy.CPLC2W and Arahy.14EF4H might play a role in modulating peanut pod and seed weight. These findings could facilitate further research into the genetic mechanisms influencing pod and seed weight in cultivated peanut.
Modulation of Skin Cancer by the Stimulator of Interferon Genes
Authors: Oscherwitz Max , Jiminez Victoria , Terhaar Hanna , Yusuf Nabiha
Published: September 2023

Morbidity and mortality from skin cancer continue to rise domestically and globally, and melanoma and non-melanoma skin cancers are a topic of interest in the dermatology and oncology communities. In this review, we summarize the stimulator of interferon genes (STING) pathway, its specific role in the pathogenesis of DNA damage and skin cancer, and STING-specific therapies that may fight both melanoma and non-melanoma skin (NMSC) cancers. Furthermore, we discuss specific portions of the STING pathway that may be used in addition to previously used therapies to provide a synergistic effect in future oncology treatments and discuss the limitations of current STING-based therapies.
In Situ Alteration of the Hydro-Mechanical Behaviour of a Compacted Stabilised Expansive Soil
Authors: Chabrat Nicolas , Cuisinier Olivier , Masrouri Farimah
Published: September 2023

This paper assesses the performance of an embankment constructed in 2010 with a stabilised expansive soil. Two types of treatment were employed at construction time: 4% lime and a mix of 2% lime and 3% cement. A sampling campaign was carried out in 2021 to evaluate the long-term performance of the stabilised soil properties. To assess the compressibility of the soil, oedometer tests were carried out on samples from different parts of the embankment. The results were compared to the compression curve of the untreated soil, also sampled in the same embankment. Complementary shrinkage tests were performed to investigate the effect of the treatment on swelling and shrinkage. The obtained results show that the yield stress of the material from the outer part was inferior to 100 kPa, similarly to the yield stress of the untreated soil, demonstrating a strong alteration in the effect of both treatments over time. This alteration was noticeable to a distance of approximately 2 m from the external surface. Beyond this distance, the performance of the soil was comparable to the behaviour of recently treated soil, with yield stresses close to 1000 kPa. These observations, similar for each treatment dosage, raise questions as to the durability of the treatment on the outer part of the backfill.
Primary Care Disease Management for Venous Leg Ulceration in German Healthcare: Results of the Ulcus Cruris Care Pilot Study
Authors: Senft Jonas D. , Fleischhauer Thomas , Poß-Doering Regina , Frasch Jona , Feißt Manuel , Awounvo Sinclair , Müller-Bühl Uwe , Altiner Attila , Szecsenyi Joachim , Laux Gunter
Published: September 2023

Despite proven effectiveness, compression therapy is applied in only 20–40% of patients with venous leg ulceration, leading to avoidable chronification and morbidity. The Ulcus Cruris Care project was established to develop a new disease-management concept comparable to existing programs for chronic diseases to support evidence-based treatment of venous leg ulceration. This prospective controlled study assessed its first implementation. Interventional elements comprised online training for general practitioner practices, software support for case management, and educational materials for patients. A total of 20 practices and 40 patients were enrolled in a 1:1 ratio to the intervention and control group. Guideline-conform compression therapy was applied more frequently in the intervention group (19/20 [95%] vs. 11/19 [58%]; p = 0.006). For patients with ulcers existing ≤ 6 months, the healing rate at 12 weeks was 8/11 [73%] (intervention) compared to 4/11 [36%] (control; p = 0.087). Patients after intervention had higher scores for self-help and education in the PACIC-5A questionnaire (42.9 ± 41.6 vs. 11.4 ± 28.8; p = 0.044). Treatment costs were EUR 1.380 ± 1.347 (intervention) and EUR 2.049 ± 2.748 (control; p = 0.342). The results of this study indicate that the Ulcus Cruris Care intervention may lead to a significant improvement in care. Consequently, a broader rollout in German healthcare seems warranted.
Examining Factors Associated with E-Cigarette Use among Current Smokers
Authors: Park MinHee , Song HyeYoung
Published: September 2023

We present a secondary data analysis of the raw data from the eighth Korea National Health and Nutrition Examination Survey (KNHANES). A total of 827 current smokers who responded that they had smoked >5 packs (100 cigarettes) of cigarettes in their lifetime and were currently smoking traditional cigarettes were selected. This study was conducted to identify sociodemographic, smoking-related, and health-related characteristics that influence the use of e-cigarettes in adult smokers. To examine these factors, general characteristics such as age, marital status, education level, and occupation were included in Model 1, while health-related characteristics such as the level of smoking and depression were included in Model 2. In Model 1, age, a high level of education, and working in an office were found to be significantly correlated with e-cigarette use among smokers, while age and working in the office were found to be significantly correlated with e-cigarette use in Model 2. Therefore, e-cigarette use was high among adult smokers of young ages who were office workers. Although evidence is lacking regarding its safety and use as smoking cessation aids, many smokers have been reported to use e-cigarettes as smoking cessation aids, making it necessary to provide accurate information on e-cigarettes.
Gambling Disorder among Porto’s University Students
Authors: Azevedo Nádia Pais , Santos Paulo , Sá Luísa
Published: September 2023

Background: Gambling disorder is an emerging problem among young adults and must be researched to provide the necessary support. This study aims to characterise gambling disorders in Porto’s university students. Methods: A cross-sectional study distributed an online questionnaire to Porto’s university students. The authors developed a self-administered questionnaire that included the South Oaks Gambling Screen questionnaire—Portuguese Version (SOGS-PV). Results: A total of 1123 responses were included. The participants’ average age was 22.4 years (SD = 6.2), and 60.9% were women. Gambling activities were performed by 66.4% of the students, most commonly online or video games, “scratch card” games, skill games, lotteries, and sports bets. The final scores of the SOGS-PV suggested 19.7% (95% CI: 17.4–22.0) of students may have a gambling disorder, with 16.6% (95% CI: 14.4–18.8) being “probable pathological gamblers” and 3.1% (95% CI: 2.1–4.1) being “problem gamblers”. Gambling in the stocks/commodities market/virtual coins, sports bets, playing cards for money, and the numbers or betting on lotteries presents a higher risk of gambling disorder. The age (OR: 0.953; 95% CI: 0.922–0.986), being male (OR: 2.756; 95% CI: 1.899–4.000), the highest daily gambling amount (OR: 3.938; 95% CI: 2.580–6.012), the effects of the COVID-19 pandemic (OR: 0.129; 95% CI: 0.087–0.191), a mother with gambling disorder (OR: 5.284; 95% CI: 1.038–26.902), the personal services education area (OR: 2.858; 95% CI: 1.179–6.929), and the linguistics education area (OR: 2.984; 95% CI: 1.538–5.788) stand out as contributing factors to the development of this disorder. Conclusions: This study reveals a high level of possible gambling disorder among university students and emphasises the importance of this problem in the academic community. Physician awareness and prevention programmes are needed in this population.
Cariprazine in an Adolescent with Tourette Syndrome with Comorbid Attention Deficit Hyperactive Disorder and Depression: A Case Report
Authors: Gill Jesjeet Singh
Published: September 2023

Tourette syndrome is a complex neuropsychiatric condition that manifests in childhood and is often associated with other psychiatric comorbidities. This case report describes a young male with Tourette syndrome with major depressive disorder and attention deficit hyperactivity disorder (ADHD) who experienced troublesome side effects due to his existing medications (escitalopram, risperidone, and methylphenidate). In order to control his tics, ameliorate depressive symptoms, and eliminate side effects of stiffness and sedation, risperidone was switched to cariprazine, a third-generation antipsychotic medication with D3-D2 partial agonism. In addition, the antidepressant dose was also increased. With the new combination, the patient reported good control of his tics, together with significant improvement in depressive symptoms and no side effects. Based on this case and the reviewed literature, cariprazine might be a viable option for patients with Tourette syndrome with other comorbid illnesses who are prone to side effects of medication.
Early Growth Assessment of Lolium perenne L. as a Cover Crop for Management of Copper Accumulation in Galician Vineyard Soils
Authors: Vázquez-Blanco Raquel , Arias-Estévez Manuel , Fernández-Calviño David , Arenas-Lago Daniel
Published: September 2023

This study investigates the potential use of Lolium perenne L. as a cover crop to improve vineyard soils with varying levels of copper (Cu). Cu-based fungicides are commonly used to control fungal diseases in vineyards, but their accumulation in soils poses environmental risks. This study aims to address this issue by evaluating the influence of soil properties on Cu availability and L. perenne growth. A total of 42 vineyard soils from different Designations of Origin (D.O.s) in Galicia were sampled and their physicochemical properties were analyzed. The results showed most soils exceeded recommended Cu limits due to fungicide applications. Pot experiments were conducted to assess L. perenne growth and Cu accumulation. L. perenne biomass did not vary significantly with total soil Cu content, indicating that other factors such as organic matter and cation exchange capacity were more important for plant growth. While L. perenne showed Cu tolerance, its aerial Cu accumulation was inversely correlated with available Cu. This study provides insight into the potential of L. perenne as a cover crop for sustainable vineyard management and soil improvement and emphasizes the importance of considering Cu accumulation from fungicide applications.
Impact of Titanium Oxide Nanoparticles on Growth, Pigment Content, Membrane Stability, DNA Damage, and Stress-Related Gene Expression in Vicia faba under Saline Conditions
Authors: Omar Samar A. , Elsheery Nabil I. , Pashkovskiy Pavel , Kuznetsov Vladimir , Allakhverdiev Suleyman I. , Zedan Amina M.
Published: September 2023

This study investigates the effects of titanium dioxide nanoparticles (nTiO2) on Vicia faba under salinity stress. Plants were treated with either 10 or 20 ppm nTiO2 and subjected to two different concentrations of salinity (100 and 200 mM NaCl) as well as the combined effect of nanoparticles and salinity. Salinity induced a reduction in dry weight, increased electron leakage and MDA content, increased chromosomal aberrations and DNA damage, and reduced transcript levels of some stress- and growth-related genes. nTiO2 treatment increased dry weight in unstressed plants and mitigated the salinity-damaging effect in stressed plants. nTiO2 application improved cell division, decreased chromosomal aberrations, and reduced DNA damage in plants under saline conditions. The upregulation of antioxidant genes further supports the protective role of nTiO2 against oxidative stress. Particularly significant was the ability of nTiO2 to enhance the upregulation of heat shock protein (HSP) genes. These findings underscore the potential of nTiO2 to reduce the osmotic and toxic effects of salinity-induced stress in plants.
Muscular Adaptations to Concurrent Resistance Training and High-Intensity Interval Training in Adults with Type 2 Diabetes: A Pilot Study
Authors: Orlando Giorgio , Pugh Jamie , Faulkner Steve , Balducci Stefano , Sacchetti Massimo , Pugliese Giuseppe , Bazzucchi Ilenia , Haxhi Jonida , Martinez-Valdes Eduardo , Falla Deborah , Manolopoulos Konstantinos , Nimmo Myra A.
Published: September 2023

This pilot study aimed to compare the effects of eight weeks of concurrent resistance training (RT) and high-intensity interval training (HIIT) vs. RT alone on muscle performance, mass and quality in adults with type 2 diabetes (T2DM). Twelve T2DM adults were randomly allocated to the RT + HIIT (n = 5) or RT (n = 7) group. Before and after training, maximal oxygen uptake (VO2max), muscle strength and power were evaluated by calorimetry, dynamometry and one-repetition maximum (1RM) test. Quadriceps muscle volume was determined by MRI, and muscle quality was estimated. After RT, VO2max (+12%), knee muscle power (+20%), quadriceps muscle volume (+5.9%) and quality (leg extension, +65.4%; leg step-up, +223%) and 1RM at leg extension (+66.4%), leg step-up (+267%), lat pulldown (+60.9%) and chest press (+61.2%) significantly increased. The RT + HIIT group improved on VO2max (+27%), muscle volume (+6%), muscle power (+9%) and 1RM at lat pulldown (+47%). No other differences were detected. Among groups, changes in muscle quality at leg step-up and leg extension and VO2max were significantly different. The combination of RT and HIIT effectively improves muscle function and size and increases cardiorespiratory fitness in adults with T2DM. However, HIIT combined with RT may interfere with the development of muscle quality.
Identifying Environmental Impact Factors for Sustainable Healthcare: A Scoping Review
Authors: Sijm-Eeken Marieke , Jaspers Monique , Peute Linda
Published: September 2023

The healthcare industry has a substantial impact on the environment through its use of resources, waste generation and pollution. To manage and reduce its impact, it is essential to measure the pressures of healthcare activities on the environment. However, research on factors that can support these measurement activities is unbalanced and scattered. In order to address this issue, a scoping review was conducted with the aims of (i) identifying and organizing factors that have been used to measure environmental impact in healthcare practice and (ii) analyzing the overview of impact factors in order to identify research gaps. The review identified 46 eligible articles publishing 360 impact factors from original research in PubMed and EBSCO databases. These factors related to a variety of healthcare settings, including mental healthcare, renal service, primary healthcare, hospitals and national healthcare. Environmental impacts of healthcare were characterized by a variety of factors based on three key dimensions: the healthcare setting involved, the measurement component or scope, and the type of environmental pressure. The Healthcare Environmental Impact Factor (HEIF) scheme resulting from this study can be used as a tool for selecting measurable indicators to be applied in quality management and as a starting point for further research. Future studies could focus on standardizing impact factors to allow for cross-organization comparisons and on expanding the HEIF scheme by addressing gaps.
Unveiling Market Connectedness: Dynamic Returns Spillovers in Asian Emerging Stock Markets
Authors: Khan Maaz , Khan Mrestyal , Kayani Umar Nawaz , Mughal Khurrum Shahzad , Mumtaz Roohi
Published: September 2023

This study investigates the returns spillovers across the equity markets of Asian emerging economies (China, India, Indonesia, Malaysia, Pakistan, Philippines, South Korea, Taiwan, and Thailand). To achieve this objective, we used two different spillover methodologies (DY 2012 and BK 2018). Moreover, this study used the daily closing prices of equity indices ranging from 5 January 2005 to 13 November 2021. The empirical findings revealed that the total spillover index using DY 2012, and the short-term frequency index using BK 2018, are close to each other, with values of 46.92% and 43.04%, respectively. However, the spillover index value is high, with a value of 56.25% in the long run. Furthermore, the results showed that the stock markets of South Korea and Taiwan are the major spillover transmitters in the Asian emerging markets. Also, the financial association among all emerging Asian equities is at its peak, subject to the mobility of cash flows across the global economies. The results of this study provide meaningful insight for policymakers and investors to implement an effective strategy to overcome the possible influence of any financial crisis in the future. Our paper provides a potential contribution to the financial literature by examining the transmission of spillovers across the Asian emerging stock markets. Furthermore, it provides in-depth information regarding stock market interdependence.
Recent Advances in the Aggregation Behavior of Nanoplastics in Aquatic Systems
Authors: Cid-Samamed Antonio , Diniz M. S.
Published: September 2023

This short review aims to critically discuss the recent advances in supramolecular chemistry to achieve the aggregation of nanoplastics in aquatic systems. Polymer modification provides a vital tool for designing novel and ad hoc synthesized surfactants with properties tuned for some specific applications (e.g., stimuli-responsive nanomaterial, conducting polymers), mainly to aggregate other polymers from the environment. Far from the typical use of surfactants, which ease the dispersion of insoluble molecules in water media or aid solubilization of insoluble molecules on local media, in this case, nanoarchitectonics serve researchers to design surfactants with a focus on the capture of nanoplastics from the environment. Additionally, monovalent and divalent salt additions aided NPs in coagulating in the aquatic systems. Finally, the latest research on NPs’ removal efficiency on wastewater treatment plant is reviewed to summarize the advances.