bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges as a Driving Force for the Modernization of Social Statehood in Europe
Authors: Fedorova Alla , Holovashchenko Olha
Published: July 2023

One of the most significant social achievements of the twentieth century was the development and implementation of the welfare state concept within the framework of the theory of a democratic, rule-of-law state which ensures the best option for social and economic development, as well as political stability in society. It is proved that although, since the 1970s, some economists, political scientists and lawyers have periodically sharply criticized the concept of the welfare State, predicting its decline, the positive results of its transformation in European countries, as well as the development of the European Social Community within the European Union, show that the welfare State has a chance not only to survive, but also to remain one of the fundamental principles of statehood in democratic countries, and an element of the supranational organization of power embodied in the European Union.The purpose of the article is to analyze the traditional and new challenges to the welfare state which determine the change of approaches to its functioning and priorities at the current stage of development of state-legal and interstate (integration) relations.The key idea that structures the study is the thesis that European states that form a united Europe or aspire to join it, such as Ukraine, despite belonging to the same civilizational community, retain the right to choose how to respond to the economic, social, demographic, migration, environmental and climate challenges of our time. This choice determines the future of national welfare state models. In accordance with the stated goal, the article identifies two groups of major challenges: established (demographic changes, in particular, population aging; changes in the position of women in society and in the labor market; changes in the labor market; poverty and social exclusion) and new (rapid growth of emigration of Ukrainian doctors and nurses; introduction of artificial intelligence technologies; uncontrolled mass immigration; rapid growth of disability in society) faced by the welfare state and, mainly, the social security system, which is its foundation. While the established challenges require adjustments to the priorities and tasks of the welfare state, the newest ones require a significant modernization of the welfare state, adapting it to the new political, economic and social conditions of society.Further research on the selected issues should be conducted taking into account the existence of certain models of the welfare state that unite European states either by geographical (Scandinavian, continental, Anglo-Saxon, Southern European) or ideological (liberal, conservative, social democratic, corporate, solidarity) criteria.The problem of the welfare state's response to the challenges of environmental and climate crises deserves separate development, and in the context of this consideration, the correlation between the social and environmental (“green”) state.
Theological Issues of Pandemic Covid 19 in Malaysia: The Views of The Muslims Theologians
Authors: Ramly Roslizawati Mohd
Published: July 2023

The outbreak of the pandemic COVID-19 in Malaysia started in March 2020. has not only affected  Muslims well-being in terms of socio-economic, emotional, and mental health, but it has also challenged their theological understandings, specifically relating to the issue of Qada' and Qadar and Human Freedom of Will. Consequently, some Muslims refused to observe the government order to contain the spread of COVID-19 and accused the observant of the order of committing polytheism. To clarify the issue, this study aims to identify the theological perspectives of the Muslim theologians on COVID-19 and the methods to prevent it.   This study employed a qualitative descriptive method. Data was collected through Youtube videos that contain views and responses of the well-known Muslim theologians from the school of Ahl Sunnah wal Jamaah on the theological issues related to the pandemic. The study found that the view of the Muslim theologians on COVID-19 shows that they uphold the Asha'rites understanding and teachings of the concept of Qada' and Qadar and human freedom of will. Therefore,  they regarded the observant of the SOP or Islamic guidelines in preventing the spread of pandemic Covid 19 as a form of ikhtiyar and not as a form of polytheism.
Integrity and Transparency: Public Perceptions of Religious Values Education in a Plural Society
Authors: Siswantara Yusuf , Suryadi Ace , Hidayat Mupid , Ganeswara Ganjar Muhammad
Published: July 2023

In various countries, diversity impacts social conflicts in various forms, not ethnicity, ideology, but also religion. Although many conflicts are based on diversity in Indonesia, religion is the most accessible and most conflict-prone social identity. To address the issue, tolerance or moderation education has widely campaigned. However, the rise of intolerance indicates an unformed factor, namely the perception or attitude toward religious life. Therefore, it is essential to research religious life attitudes. This study aims to analyze the perception of religious life on claims of truth, uniqueness, relations of other religions, and global ethics. For this reason, the combined method with embedded design is a choice of approach from this study. Data collection is carried out simultaneously, both qualitatively and quantitatively. The analyses of the two were combined to get a complete picture of the respondents' religious perceptions or attitudes. The renewal of this study, in addition to empirical studies on the religious attitudes of millennials, is the relationship between perceptions/attitudes of religious life to the relationship between religions through global ethical issues as a common problem. The conclusions of this study are, (1) respondents see a global problem, but at the same time, there is a universal value in religion, (2) With this universal value belief, respondents tend to be open to dialogue because they believe there is goodness in religions, (3) For the problem of dogma teachings, respondents tend to be exclusive without closing the truth of other religions. The suggestions given, among others, are (1) religious education raises the dimension of global ethics, both humanitarian and ecological; (2) religious education builds a dialogical religious attitude with three conditions: understanding one's religion (the uniqueness and peculiarities of faith), being open to other religions, and offering the value of faith to overcome the global problem
Bediuzzaman Said Nursi View on Ibn Arabi’s Concept of Wahdatul Wujud (Unity of Existence)
Authors: Nasution Alhafidh
Published: July 2023

Abstract: This article explores Bediuzzaman Said Nursi sight on Ibn ‘Arabī's Unity of Existence (Wahdatul Wujūd) concept. In several books, Said Nursi has written about the idea of Unity of Existence. All of this suggests that Nursi expressed his thoughts on the subject when responding to questions from his students about Ibn ‘Arabī and his idea of Wahdatul Wujūd. Nursi determined that Wahdatul Wujūd is of an acceptable degree and great value for the guardians (auliya'), and that the subjects of Wahdatul Wujūd cannot be taught to common people. A study uses epistemological analysis to recognize the basic concept of Wahdatul Wujūd according to Ibn ‘Arabī. As a result, Wahdatul Wujūd doctrine is divided into Sufism ideology, materialism, and naturalism.
Authority and Ulama In Aceh: The Role of Dayah Ulama In Contemporary Aceh Religious Practices
Authors: Syafieh Syafieh , Muhaini Muhaini , Syufyan Suhaili
Published: July 2023

Recently, the traditionalist ulama dayah has been questioned in Aceh. With the arrival of religious groups with a Wahhabi-Salafi pattern, Acehnese dayah ulama have lost their authority as agents or religious figures in Acehnese society. This study focuses on the authority of the dayah ulama and its role in contemporary Acehnese spiritual practice. This study aims to see the authority of the dayah ulama amid the development of Wahhabi-Salafi understanding in contemporary Aceh. By conducting interviews with the dayah ulama group, Wahhabi-Salafi groups, and related government institutions in the province of Aceh and using qualitative data analysis, the researcher found that the role of the dayah ulama was still strong in influencing the religious practice of contemporary Acehnese society as evidenced by the community's rejection of Salafist religious understanding. Fundamentalism developed in Aceh because it was not by understanding the dayah ulama, namely the doctrine of Ahlusunnah Waljamaah. In addition, there is support from the Aceh government for the religion of the dayah ulama, with evidence by the issuance of a circular regarding the obligation to worship according to the teachings and understanding of syafi'iyah in the province of Aceh.
APLICANDO UMA FERRAMENTA AVALIATIVA NO CONTEXTO DA EDUCAÇÃO CTSA
Authors: Matias Miranda Elisangela , Conrado Dalia Melissa , Nunes Neto Nei de Freitas Nunes Neto
Published: July 2023

Livros didáticos são ferramentas importantes para apoio na educação formal, e muito utilizados por docentes e discentes. Portanto, pesquisas sobre avaliação de livros didáticos são relevantes para melhor orientar a comunidade escolar na escolha e no uso deste material curricular. Neste trabalho de pesquisa qualitativa, documental e exploratória, analisamos um livro didático aprovado para os três anos do Ensino Médio, na área de Ciências da Natureza e suas Tecnologias. Utilizamos uma ferramenta avaliativa sobre a perspectiva CTS e concluímos que o livro ainda precisa ser complementado por outros materiais e temas para discussão, a fim de melhor fornecer subsídios para o alcance dos objetivos da educação CTSA. Também recomendamos outras ferramentas para avaliação das relações CTSA presentes em materiais curriculares.
REFLEXÕES SOBRE A ATUAÇÃO DO ESTAGIÁRIO NA EDUCAÇÃO INFANTIL COM CRIANÇAS QUE APRESENTAM NECESSIDADES EDUCACIONAIS ESPECÍFICAS
Authors: Brito Pessoa Da Silva Katiene Symone
Published: July 2023

O ambiente escolar teve necessidade de remodelação para que se tornasse apto a incluir crianças com necessidades educacionais específicas. A partir disso surgiram novas demandas para este espaço escolar, dentre elas, a necessidade de sujeitos para facilitar a inclusão dessas crianças, momento em que entram em ação o estágio não obrigatório. Deste modo, este artigo busca refletir como ocorre a atuação de estudantes do curso de pedagogia, de uma instituição pública do estado do RN, como estagiários, bem como os desafios enfrentados, na Educação Infantil acompanhando crianças com necessidades educacionais específicas (NEE), em unidades públicas de ensino de Natal/RN. A pesquisa foi desenvolvida através de uma abordagem metodológica qualitativa, aplicados questionários com sete (7) estudantes em estágio não obrigatório, a fim de analisar como ocorre a prática do estágio junto às crianças com NEE, na Educação Infantil. A partir dos resultados, foi possível refletir sobre a prática do estágio não obrigatório, as dificuldades enfrentadas, bem como acerca do aporte oferecido por esses estagiários, que mesmo ainda em processo de formação inicial, e não possuindo uma formação especializada na área da Educação Especial, colaboram com a inclusão e desenvolvimento das crianças com NEE.
Sunitinib Induced Disseminated Intravascular Coagulation after COVID-19
Infection in a Patient with Neuroendocrine Tumor: A Case Report
Authors: Tareen Mona , Zuluaga Julieta O , El khoury Maroun , Salem Sameh , Khan Faraz
Published: July 2023

Background:

Disseminated intravascular coagulation (DIC) is a known complication of malignancy. Drug-induced DIC is also reported. Sunitinib is a tyrosine kinase inhibitor approved as an oral targeted therapy in the treatment of different cancers. Here we present a case study of disseminated intravascular coagulation following the administration of Sunitinib after COVID-19 infection in a patient diagnosed with metastatic neuroendocrine tumor of the lung.

Case Report:

A 35-year-old male patient with a known metastatic lung neuroendocrine tumor (NET) who was treated with Sunitinib for many years with partial response and tolerating the treatment well-developed recurrent DIC on Sunitinib after COVID-19 infection.

Discussion:

COVID-19 infection is reported to be associated with endothelial injury and inflammation. Vascular endothelial growth factor (VEGF) receptors have a role in the protection and modulation of endothelium. Sunitinib is a multikinase inhibitor with anti- VEGF effect. It is possible that endothelial injury after COVID-19 may have triggered recurrent DIC in this patient who had previously tolerated the same drug without problems.

Conclusion:

DIC may be underreported especially with antineoplastics having anti-VEGF effects. Potential risk, interaction, and association with COVID-19 infection in the Era of the pandemic are unclear but warrants further research, and drug-induced DIC should be considered in the differential diagnosis of such cases.
Autophagy Behavior in Endothelial Cell Dysfunction
Authors: Marzoog Basheer Abdullah
Published: July 2023

Autophagy regulates endothelial cell homeostasis. Autophagy is a catabolic process involving degradation of intracellular components.
Dysregulation of autophagy induces endothelial cell dysfunction. Endothelial cell dysfunction is a multifactorial pathophysiological change that
occurs at the cellular and subcellular levels. Lipophagy and mitophagy are hallmarks of the pathogenesis of endothelial cell dysfunction. The
regulation of the autophagy mechanism involved amino acids, growth factors, hormones, myo-inositol-1,4,5-triphosphate, calpain, calcium, bcl-2,
reactive oxygen species, BNIP3, DRAM, p19ARF, FADD and TRAIL. Down-regulation of autophagy reduces endothelial cell resistance to
stressful conditions such as shear stress, deprivation of oxidative stress, nutrients deprivation, and hypoxemia. Autophagy optimizes endothelial
cell function, increases longevity, slows senescence, and prevents endothelial cell transdifferentiation. Pathophysiologically, autophagy is inhibited
in endothelial cells due to mTORC1 repression release. Also, AMPK expression repression downregulates autophagy and subsequently endothelial
dysfunction. The paper provides state of art on the current advances in the autophagy role in endothelial cell dysfunction.
Cognitive Versus Hemorrhagic Onset in Cerebral Amyloid Angiopathy:
Neuroimaging Features
Authors: Perini Giulia , Ramusino Matteo Cotta , Farina Lisa Maria , Fabbro Beatrice Dal , Canavero Isabella , Picascia Marta , Muzic Shaun , Ballante Elena , Cavallini Anna , Pichiecchio Anna , Costa Alfredo
Published: July 2023

Background:

Intracerebral hemorrhage and cognitive decline are typical clinical presentations
of cerebral amyloid angiopathy (CAA).

Objective:

To determine whether magnetic resonance imaging (MRI) features differ between CAA
with hemorrhagic versus cognitive onset.

Methods:

In this retrospective study, sixty-one patients with CAA were classified by onset presentation
of the disease: hemorrhage (n = 31) or cognitive decline (n = 30). The two groups were compared
for MRI markers of small vessel disease, namely cerebral microbleeds (CMBs), cortical superficial
siderosis, white matter hyperintensities (WMHs), enlarged perivascular spaces, cortical microinfarcts,
and visual rating scales for cortical atrophy. In the patients with cognitive onset, further exploratory
analyses investigated MRI markers according to cerebrospinal fluid (CSF) and neuropsychological
profiles.

Results:

Patients with cognitive onset showed a higher prevalence of CMBs (p < 0.001), particularly
in temporal (p = 0.015) and insular (p = 0.002) lobes, and a higher prevalence of WMHs (p = 0.012).
Within the cognitive onset group, 12 out of 16 (75%) patients had an Alzheimer’s disease (AD) CSF
profile but did not differ in MRI markers from those without AD pathology. Patients with cognitive
onset displayed a multidomain profile in 16 out of 23 (70%) cases; patients with this profile showed
increased WMHs and CMBs in parietal lobes compared with the amnestic group (p = 0.002) and
dysexecutive group (p = 0.032), respectively.

Conclusion:

Higher burdens of WMHs and CMBs, especially in temporal and insular lobes, are associated
with the cognitive onset of CAA. MRI markers could help to shed light on the clinical heterogeneity
of the CAA spectrum and its underlying mechanisms.
Relevance of Infertility, Epigenetics, Nutrient, and Bioactive Components:
A Review of the Literature
Authors: Erdogan Kadriye , Sanlier Nazli Tunca , Sanlier Nevin
Published: July 2023

Background:

This review discusses epigenetic mechanisms and the relationship of infertility in men and women in relation to parameters pertaining to nutrition.

Methods:

A review of the line of the literature was conducted prior to June 2021 through the selected websites, including MEDLINE, Embase, Web of Science, www.ClinicalTrials.gov, Cochrane Central, PubMed, Google Scholar, Science Direct, and the WHO.

Results:

The prevalence of infertility worldwide is 8-12%, and one out of every 8 couples receives medical treatment. Epigenetic mechanisms, aging, environmental factors, dietary energy and nutrients and non-nutrient compounds; more or less energy intake, and methionine play a role in the onset of infertility. Furthermore, more factors that contribute to infertility include the vitamins B12, D, and B6, biotin, choline, selenium, zinc, folic acid, resveratrol, quercetin, and others..

Discussion:

To understand the molecular mechanisms regulating the expression of genes that affect infertility, the environment, the role of genotype, age, health, nutrition, and changes in the individual's epigenotype must first be considered. This will pave the way for the identification of the unknown causes of infertility. Insufficient or excessive intake of energy and certain macro and micronutrients may contribute to the occurrence of infertility as well. In addition, it is reported that 5-10% of body weight loss, moderate physical activity and nutritional interventions for improvement in insulin sensitivity contribute to the development of fertility.

Conclusion:

Epigenetic processes involve inherited changes but not encoded by the DNA sequence itself. Nutrition is thought to affect the epigenetic mechanisms that play a role in the pathogenesis of many diseases, including infertility. Epigenetic mechanisms of individuals with infertility are different from healthy individuals. Infertility is associated with epigenetic mechanisms, nutrients, bioactive components and numerous other factors.
Phytochemical, Pharmacological, and Toxicological Prospection of Morus
nigra L.: A Systematic Review
Authors: Alves Larissa Pereira , dos Santos Widson Michael , de Souza Myla Lôbo , Rolim Larissa Araújo , Rolim-Neto Pedro José
Published: July 2023

Introduction:

Morus nigra L. has industrial relevance due to the presence of specialized metabolites,
which possess pharmaceutical potential in various parts and preparations. This review presents
updated information on traditional, phytochemical, and pharmacological applications, as well as toxicity
data, pertaining to different parts of Morus nigra L.

Method:

Phytochemical research and ethnobotanical studies were conducted using reviewed databases.
Mulberry leaves have demonstrated several biological activities, attributed to the presence of phenolic
acids, flavonoids, and fatty acids. Stems and roots contain additional compounds such as stilbenes and
benzofurans. Morus nigra L. exhibits various biological activities, including hepatoprotective, hypolipidemic,
anti-inflammatory, antioxidant, antimicrobial, neuroprotective, hypoglycemic, skin whitening,
cytotoxic, antiatherosclerotic, and antiobesity effects. The choice of extraction technique and plant part is
crucial to obtain a diverse range of compounds necessary for specific indications.

Result:

Accelerated solvent extraction (ASE) has proven to be the most advantageous method compared
to supercritical fluid maceration and extraction (SFE), yielding a wide variety of compounds.

Conclusion:

Overall, this review aims to provide scientists and companies interested in Morus nigra L.
with opportunities and challenges for innovation in this field.
WITHDRAWN: A Review on the Role of Nanotechnology for Sustainable Agriculture to Increase Crop Productivity
Authors: Singh Rajani , Mishra Sunita
Published: July 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has
been withdrawn from the website of the journal Nanoscience & Nanotechnology-Asia.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorialpolicies-main.php.

ENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
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elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden,
and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate
action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors
agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Uma anedota de Vinicius de Moraes e João Cabral de Melo Neto: do coração e do cérebro
Authors: Pucheu Alberto
Published: July 2023

Based on an event between Vinicius de Moraes and João Cabral de Melo Neto, the essay addresses an anecdote that, concerning a double caricature between the heart and the brain, intrinsically concerns the history of Brazilian poetry and its developments in the last decades of the 20th century, dealing with a certain paradigm of thought of Western modernity that crosses avant-garde positions: reason X heart (or: antimusical X musical; non-lyrical X lyrical; construction X spontaneity; intellectualism X sentimentality etc. etc. etc.). In addition to thematizing the meaning of what an anecdote is, the text seeks to go through oral and written narratives from which the respective anecdote was and continues to be told and constructed. It is not the intention of this essay to think or rethink the poetry of Cabral or Vinicius in a new key, much less to think of it as against the reading that the former carries out of himself and his friend, but dealing only with the anecdote in question and, consequently, with a caricature.
Usos do coração
Authors: Braz Paulo
Published: July 2023

António Franco Alexandre presents, in his work, a deep articulation between body and language, which we can denominate a poetics of the senses. Through a critical investigation that crosses the discussions around the “return to real”, proposed by Joaquim Manuel Magalhães, we try to understand the contemporaneity of the author of Aracne in a view of the passion inscribed in his poetry, which implies a particular configuration of alterity in the inscription of a you as a way of constructing senses.
A comprehensive analysis of research trends on andropause among middle-aged South Korean men
Authors: Lee Young Hwa , Park Sun Jung , Kim Hyun Ji , Park Bock Soon , Jang Hyo Yeol , Cho Ha Na , Lim Young Sook
Published: July 2023

The objective of this study is to establish foundational data for comprehending the dynamics of research on andropause among middle-aged men. Additionally, it aims to identify potential applications for the development of counseling and education programs tailored specifically to this demographic, as well as to outline future directions and implications for further studies on middle-aged men. This study employs a descriptive research approach, analyzing the literature published in Korea over the past decade that pertains to andropause among middle-aged men. Over the course of the decade spanning from 2012 to 2022, a total of 22 papers addressing andropause-related studies among middle-aged men were identified in Korea. By examining the outcomes of these studies, the following four categories were delineated: understanding the nature of andropause in middle-aged men, comparing andropause experiences among middle-aged men, exploring correlations between andropause and other variables, and investigating causality between andropause and other variables. The findings of this study hold promise in raising awareness among the general population regarding the potential occurrence of andropause in men. Currently, societal policies and perceptions predominantly focus on menopausal care for women. By highlighting the physical, social, and mental changes experienced by men, this research can contribute to enhancing overall awareness and understanding of andropause, thus maximizing its impact.
Синтез методом молекулярно-пучковой эпитаксии и свойства InAs-квантовых точек в теле AlGaAs нитевидных нанокристаллов
Authors: Резник Р.Р. , Гридчин В.О. , Котляр К.П. , Хребтов А.И. , Убыйвовк Е.В. , Драгунова А.С. , Крыжановская Н.В. , Цырлин Г.Э.
Published: July 2023

We present the results of experimental studies on the synthesis by molecular-beam epitaxy of AlGaAs nanowires with InAs quantum dots. The morphological, structural, and optical properties of the grown nanostructures have been studied. It is important to note that the emission from quantum dots is observed in the wavelength range from 750 to 970 nm. Assumptions about the nature of short-wavelength emission from quantum dots are formulated. In particular, one of the reasons may be a significant desorption of indium atoms and the presence of gallium atoms in catalyst drops during the growth at a substrate temperature of 510◦C. The proposed technology opens up new possibilities for integration direct-gap III−V materials with a silicon platform for various applications in photonics and quantum communications.
Исследование динамики включения низковольтных InP-гомотиристоров
Authors: Слипченко С.О. , Соболева О.С. , Подоскин А.А. , Кириченко Ю.К. , Багаев Т.А. , Яроцкая И.В. , Пихтин Н.А.
Published: July 2023

A series of heterostructure designs of low-voltage InP homothyristors have been investigated using numerical simulation methods. The design with a space charge layer formed in the p-base region of the n-p-n transistor part was considered as the base one. The dynamic characteristics and processes that determine the rate of transition to the on state are investigated. It is shown that as the p-base thickness increases from 1 to 2.6 μm, the maximum on-state currents increase from 70 to 90 A, while the minimum turn-on transition time is 11 ns at a maximum blocking voltage of 55 V. It is shown that the operation efficiency in the on state is determined by the residual voltage. Residual voltage decreases with a decrease in the thickness of the p-base.
Robotics in Nursing: Protocol for a Scoping Review (Preprint)
Authors: Darko Elizabeth Mirekuwaa , Kleib Manal , Lemermeyer Gillian , Tavakoli Mahdi
Published: July 2023

BACKGROUND

Globally, health care systems are challenged with the shortage of health care professionals, particularly nurses. The decline in the nursing workforce is primarily attributed to an aging population, increased demand for health care services, and a shortage of qualified nurses. Stressful working conditions have also increased the physical and emotional demands and perceptions of burnout, leading to attrition among nurses. Robotics has the potential to alleviate some of the workforce challenges by augmenting and supporting nurses in their roles; however, the impact of robotics on nurses is an understudied topic, and limited literature exists.

OBJECTIVE

We aim to understand the extent and type of evidence in relation to robotics integration in nursing practice.

METHODS

The Joanna Briggs Institute methodology and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist will guide the scoping review. The MEDLINE (Ovid), Embase (Ovid), CINAHL Plus with Full Text (EBSCOhost), Scopus, Cochrane Library, and IEEE Xplore electronic bibliographic databases will be searched to retrieve papers. In addition, gray literature sources, including Google Scholar, dissertations, theses, registries, blogs, and relevant organizational websites will be searched. Furthermore, the reference lists of included studies retrieved from the databases and the gray literature will be hand-searched to ensure relevant papers are not missed. In total, 2 reviewers will independently screen retrieve papers at each stage of the screening process and independently extract data from the included studies. A third reviewer will be consulted to help decision-making if conflicts arise. Data analysis will be completed using both descriptive statistics and content analysis. The results will be presented using tabular and narrative formats.

RESULTS

The review is expected to describe the current evidence on the integration and impact of robots and robotics into nursing clinical practice, provide insights into the current state and knowledge gaps, identify a direction for future research, and inform policy and practice. The authors expect to begin the data searches in late January 2024.

CONCLUSIONS

The robotics industry is evolving rapidly, providing different solutions that promise to revamp health care delivery with possible improvements to nursing practice. This review protocol outlines the steps proposed to systematically investigate this topic and provides an opportunity for more insights from scholars and researchers working in the field.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/50626
Development and Testing of an Electronic Diabetes Diary Integrated With a Hospital Information System for Individuals With Type 2 Diabetes Mellitus: Protocol for a Mixed Methods Study (Preprint)
Authors: Skaria Geena , Reshmi Bhageerathy , K M Sabu , Shetty Sahana , Lakshmi R Vani
Published: July 2023

BACKGROUND

Type 2 diabetes mellitus (T2DM) is one of the leading noncommunicable diseases that require diabetes self-management (DSM) practices. This study proposes to develop a customized mobile health (mHealth) app integrated with a hospital information system (HIS) to enable real-time, two-way transfer of information between the patient and physician. The captured information in the electronic health record will facilitate physicians to have a chronological account of the patient’s diabetes history and enable tweaking of the treatment.

OBJECTIVE

The objectives of the study are (1) to develop the HIS-integrated Electronic Diabetes Diary (EDDy) per the end-user expectations at a tertiary care hospital in a south Indian state with a high prevalence of T2DM and (2) to evaluate and test adherence to EDDy in the management of T2DM.

METHODS

The study will be carried out in 3 phases. Phase 1 involved in-depth interviews with primary end users to gather information regarding their expectations from the hospital-based EDDy. Phase 2 will use this information to develop a customized mHealth app using an iterative model of software development. Phase 3 will involve a pre- and posttest design; the developed app will be tested among consenting patients, where physicians will receive the patients’ data through the HIS-integrated mHealth app. The pre- and posttest values will be analyzed for adherence leading to improvement in patients’ self-management of blood glucose, user experience, glycemic control, and clinical utility.

RESULTS

Phase 1 was completed on November 28, 2023. Phase 2 commenced in December 2023 and will end in May 2025. Phase 3 will follow afterward.

CONCLUSIONS

The proposed app will include a convenient and simple alert system that enables the patient to test glucose values at self-selected intervals, provide grading options to enter diabetic-related complications, enhance patients’ knowledge of tracking and managing the complications of diabetes, and help in maintaining the visual representation of glucose values and complications. The simplicity and usability of the modules are its novelty, which may motivate the patients to keep track of their glucose values and help them attain better health outcomes.

CLINICALTRIAL

Clinical Trial Registry India CTRI/2023/03/051077; http://tinyurl.com/4tau4ndb

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/50732
Virtual Clinic Telehealth Abortion Services in the United States One Year After Dobbs: Landscape Review (Preprint)
Authors: Koenig Leah R , Ko Jennifer , Upadhyay Ushma D
Published: July 2023

BACKGROUND

Telehealth abortion has taken on a vital role in maintaining abortion access since the Dobbs v. Jackson Women’s Health Organization Supreme Court decision. However, little remains known about the landscape of new telehealth-only virtual clinic abortion providers that have expanded since telehealth abortion first became widely available in the United States in 2021.

OBJECTIVE

This study aimed to (1) document the landscape of telehealth-only virtual clinic abortion care in the United States, (2) describe changes in the presence of virtual clinic abortion services between September 2022, following the Dobbs decision, and June 2023, and (3) identify structural factors that may perpetuate inequities in access to virtual clinic abortion care.

METHODS

We conducted a repeated cross-sectional study by reviewing web search results and abortion directories to identify virtual abortion clinics in September 2022 and June 2023 and described changes in the presence of virtual clinics between these 2 periods. In June 2023, we also described each virtual clinic’s policies, including states served, costs, patient age limits, insurance acceptance, financial assistance available, and gestational limits.

RESULTS

We documented 11 virtual clinics providing telehealth abortion care in 26 states and Washington DC in September 2022. By June 2023, 20 virtual clinics were providing services in 27 states and Washington DC. Most (n=16) offered care to minors, 8 provided care until 10 weeks of pregnancy, and median costs were US $259. In addition, 2 accepted private insurance and 1 accepted Medicaid, within a limited number of states. Most (n=16) had some form of financial assistance available.

CONCLUSIONS

Virtual clinic abortion providers have proliferated since the Dobbs decision. We documented inequities in the availability of telehealth abortion care from virtual clinics, including age restrictions that exclude minors, gestational limits for care, and limited insurance and Medicaid acceptance. Notably, virtual clinic abortion care was not permitted in 11 states where in-person abortion is available.
The effect of educational intervention based on social media on mental health literacy of high school students in Ramhormoz city: Study Protocol of a Randomized Controlled Trial (Preprint)
Authors: Garmaroudi Gholamreza
Published: July 2023

BACKGROUND

Adolescence is a critical period for developing and maintaining good habits for mental health and well-being. This is important for future mental health; as most mental health problems emerge during adolescence. Mental health literacy is the basis for preventing mental health, reducing stigma and increasing the effectiveness of help-seeking, especially among adolescents.

OBJECTIVE

This study will be conducted with the aim of measuring the effect of educational intervention based on social media on mental health. Literacy of high school students in Ramhormoz city.

METHODS

This Randomized Controlled Trial (RCT) will evaluate the effectiveness of a researcher-developed intervention based on social media, which will be designed according to the core components of The Guide educational package. The study will include all high schools in Ramhormoz (Iran). A stratified random sampling method will be used. The measures of mental health literacy and attitude towards seeking professional psychological help will be assessed at the beginning (before the intervention), 3 months, and 6 months after the intervention.

RESULTS

We expect that the intervention group will have a significant improvement in their mental health literacy score compared to the control group at post-intervention and at both follow-ups. We also expect that the intervention group will have a significant improvement in their attitude towards seeking professional psychological help score compared to the control group at post-intervention and at 3-month follow-up, but not at 6-month follow-up.

CONCLUSIONS

Our study will aim to show that a social media-based educational intervention can effectively improve the mental health literacy and attitude towards seeking professional psychological help of high school students in Ramhormoz city. Our study will demonstrate the potential of using social media as a platform for delivering mental health education to adolescents in a low-resource setting. Our study will also provide evidence-based and culturally appropriate content and strategies for improving mental health literacy among adolescents in Iran and other similar contexts. Our study will have important implications for policy makers, educators, health professionals, and researchers who are interested in using social media for mental health promotion and prevention among adolescents.

CLINICALTRIAL

This study protocol has been registered with the Iranian Registry of Clinical Trials (IRCT) under the registration number IRCT20230603058372N1. The registration date is June 5, 2023. The study protocol adheres to the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines. The SPIRIT checklist is provided as Additional file 1.
Development of a Management App for Postviral Fibromyalgia-Like Symptoms: Patient Preference-Guided Approach (Preprint)
Authors: Blanchard Marc , Koller Cinja Nadana , Azevedo Pedro Ming , Prétat Tiffany , Hügle Thomas
Published: July 2023

BACKGROUND

Persistent fibromyalgia-like symptoms have been increasingly reported following viral infections, including SARS-CoV-2. About 30% of patients with post–COVID-19 syndrome fulfill the fibromyalgia criteria. This complex condition presents significant challenges in terms of self-management. Digital health interventions offer a viable means to assist patients in managing their health conditions. However, the challenge of ensuring their widespread adoption and adherence persists. This study responds to this need by developing a patient-centered digital health management app, incorporating patient preferences to enhance usability and effectiveness, ultimately aiming to improve patient outcomes and quality of life.

OBJECTIVE

This research aims to develop a digital health self-management app specifically for patients experiencing postviral fibromyalgia-like symptoms. By prioritizing patient preferences and engagement through the app’s design and functionality, the study intends to facilitate better self-management practices and improve adherence.

METHODS

Using an exploratory study design, the research used patient preference surveys and usability testing as primary tools to inform the development process of the digital health solution. We gathered and analyzed patients’ expectations regarding design features, content, and usability to steer the iterative app development.

RESULTS

The study uncovered crucial insights from patient surveys and usability testing, which influenced the app’s design and functionality. Key findings included a preference for a symptom list over an automated chatbot, a desire to report on a moderate range of symptoms and activities, and the importance of an intuitive onboarding process. While usability testing identified some challenges in the onboarding process, it also confirmed the importance of aligning the app with patient needs to enhance engagement and satisfaction.

CONCLUSIONS

Incorporating patient feedback has been a significant factor in the development of the digital health app. Challenges encountered with user onboarding during usability testing have highlighted the importance of this process for user adoption. The study acknowledges the role of patient input in developing digital health technologies and suggests further research to improve onboarding procedures, aiming to enhance patient engagement and their ability to manage digital health resources effectively.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/32193
Association between upper extremity muscle function and perfusion in children for predicting the effectiveness of rehabilitation in the post-traumatic period
Authors: Vakulenko L. , Obolonska O. , Nekhanevych O. , Golyk V. , Obolonska T.
Published: July 2023

Background. The adverse social situation in Ukraine and an increase in the number of injured children lead to a burden on trauma departments and rehabilitation centers. Looking for simple methods to help detect violations of compensatory mechanisms, one of which is the centralization of blood circulation, and impaired perfusion at the microcirculatory periphery level is of great current relevance. Materials and methods. A comprehensive clinical and functional examinations were applied to 44 children aged 10–15 years, 21 of them had home-related upper extremity fractures (main group), 23 otherwise healthy children served as the control group. All the children underwent the Box and Block Test (BBT), and the perfusion index (PI) from the extremities was recorded. Results. The BBT performance was characterized by a 1.6-fold decrease (p < 0.05) in the affected extremity of children aged 10–15 years under the rehabilitation treatment compared to that of the non-dominant extremity in healthy children and a 1.3-fold decrease (p < 0.05) in the healthy extremity compared to the dominant one. PI decreased to 2.52 ± 0.58 at rest in the main group children who underwent upper extremity rehabilitation treatment for injuries compared to 3.49 ± 0.34 (p < 0.05) in healthy children. PI reduced to 1.57 ± 0.56 in injured children at exercise loads versus 2.93 ± 0.91 (p < 0.05) in healthy children. The dynamics of recovery also differed and amounted to 2.82 ± 0.45 in the main group versus 4.00 ± 0.64 in the control group. Children with PI up to 1.5 ± 0.4 had significantly lower BBT scores at the beginning of exercise training. PI reduction to less than 1.5 allowed predicting a decrease in muscle functions, delayed wound healing, and the need for analgesia. With an increase in PI to 2.40 ± 0.54 during exercise training, children performed BBT better, while those who had a decrease in perfusion up to 0.98 ± 0.20 performed it twice as slowly (p < 0.05). As a study result, an association between the physical exercise load, changes in PI and BBT has been revealed. Conclusions. BBT scores were characterized by a 1.6-, 2.0- and 1.8-fold (p < 0.05) reduction during the first, second and third measurements, respectively, compared to those of healthy children. Characteristic feature of perfusion index was a statistically significant decrease before and during exercise training as well as slow dynamics of recovery. The correlations between perfusion index and BBT have proven the association of the rehabilitation processes and blood flow restoration.
Peculiarities of autonomic regulation and anxiety level in schoolchildren with primary hypertension
Authors: Nechytailo D.Yu. , Nechytailo T.A. , Mikhieieva T.M.
Published: July 2023

Background. An imbalance of the autonomic nervous system, or a syndrome of autonomic dysfunction, is a pathological condition characterized by a violation of the autonomic regulation of the functions of internal organs, blood vessels, and metabolic processes. This is a polymorphic pathology in which various organs and systems in children suffer, but the dominant role in the clinical picture is given to the cardiovascular disorders that is manifested by an increase of blood pressure. The purpose of the study: to assess the state of the autonomic nervous system and the level of anxiety in children with primary hypertension. Materials and methods. Forty-three children of high school age were examined. The main group included 21 children with a confirmed diagnosis of primary hypertension, and the control group — 22 children with a normal blood pressure level. The state of the autonomic nervous system was assessed using the Wayne A.M. questionnaire. The level of anxiety was evaluated according to the State-Trait Anxiety Inventory (STAI). Results. Evaluation of the level of anxiety revealed that the average level of reactive anxiety in children of the main group on the STAI was 37.3 points, which indicated a moderate level, while in the children of the control group it was low (26.6 points). The average level of personal anxiety in children of the main group was 42.6 points, which actually indicated an increase in the general level of anxiety, in the control group this indicator was low and amounted to 28.7 points (p < 0.005). Conclusions. In children with hypertension, autonomic dysfunction with a predominance of sympathicotonia is more likely to be observed, which indicates a deep pathogenetic connection between an increase in blood pressure and disorders of the autonomic nervous system. Children with hypertension probably have a higher level of personal anxiety compared to those with normal blood pressure, which must be taken into account in the treatment and prevention of this disease.
Acute hepatitis of unknown origin in children: analysis of probable etiologies
Authors: Boyarchuk O.R. , Pavlyshak V.V.
Published: July 2023

Background. An outbreak of hepatitis of unknown origin in children aged 1 month — 16 years was first reported by the WHO in April 2022. It was accompanied by a high frequency of acute liver failure, and up to 5 % of children required liver transplantation. The purpose of the review was to determine probable etiological factors and mechanisms of acute hepatitis of unknown origin based on a systematic analysis of literary sources. Materials and methods. We conducted a search for studies on cases or case series of acute hepatitis of unknown origin in the PubMed between January 2022 and February 2023. A combination of the following terms was used for the search: “unknown hepatitis”, “hepatitis of unknown origin”, “non-A-E hepatitis”, “hepatitis of unknown etiology” and “children”. Results. According to the search results, 312 publications were found. After the selection, 14 publications were included in the review. A systematic analysis of 1,188 cases of acute hepatitis of unknown origin, which corresponded to the identified case, showed a high variability of causative agents. However, most children were tested positive for adenovirus (almost 57 %), and 14 % of children had a positive PCR for SARS-CoV-2. Among other viruses detected in children, viruses of the herpes family should be noted, especially human herpesvirus 7 (34.2 %), human herpesvirus 6 (20 %), Epstein-Barr virus (18.2 %), cytomegalovirus (9.2 %). Rhinovirus (40.7 %), enterovirus/rhinovirus (28.7 %), parainfluenza virus (15.4 %), streptococcal infection, and other pathogens were also found. Conclusions. Viruses, genetic predisposition and other factors that change the body’s immune response play an important role in the development of an outbreak of severe hepatitis. Systematic analysis has shown that human adenovirus most often acts as a helper for adeno-associated virus 2, which plays a major role in initiating an immune response in genetically predisposed individuals, causing acute hepatitis and acute liver failure. SARS-CoV-2 infection probably also plays a certain role in immune activation and in the development of hyperinflammation, as do other viruses that act as helpers for adeno-associated virus 2. Continued collection of detailed clinical, microbiological, and epidemiological data on probable cases, as well as well-planned and coordinated follow-up studies are necessary to identify risk factors and other etiological factors associated with this disease.