bluuebunny/crossref_metadata_2025 huggingface dataset:
Divergent effects of listening demands and evaluative threat on listening effort in online and laboratory settings
Authors: Carolan Peter J. , Heinrich Antje , Munro Kevin J. , Millman Rebecca E.
Published: January 2024

Objective

Listening effort (LE) varies as a function of listening demands, motivation and resource availability, among other things. Motivation is posited to have a greater influence on listening effort under high, compared to low, listening demands.

Methods

To test this prediction, we manipulated the listening demands of a speech recognition task using tone vocoders to create moderate and high listening demand conditions. We manipulated motivation using evaluative threat, i.e., informing participants that they must reach a particular “score” for their results to be usable. Resource availability was assessed by means of working memory span and included as a fixed effects predictor. Outcome measures were indices of LE, including reaction times (RTs), self-rated work and self-rated tiredness, in addition to task performance (correct response rates). Given the recent popularity of online studies, we also wanted to examine the effect of experimental context (online vs. laboratory) on the efficacy of manipulations of listening demands and motivation. We carried out two highly similar experiments with two groups of 37 young adults, a laboratory experiment and an online experiment. To make listening demands comparable between the two studies, vocoder settings had to differ. All results were analysed using linear mixed models.

Results

Results showed that under laboratory conditions, listening demands affected all outcomes, with significantly lower correct response rates, slower RTs and greater self-rated work with higher listening demands. In the online study, listening demands only affected RTs. In addition, motivation affected self-rated work. Resource availability was only a significant predictor for RTs in the online study.

Discussion

These results show that the influence of motivation and listening demands on LE depends on the type of outcome measures used and the experimental context. It may also depend on the exact vocoder settings. A controlled laboratory settings and/or particular vocoder settings may be necessary to observe all expected effects of listening demands and motivation.
Perceived competence in ice hockey and its associations with relative age, early sport specialization, and players’ position
Authors: Huard Pelletier Vincent , Lemoyne Jean
Published: January 2024

Introduction

Ice hockey is a sport that has gained much attention in recent times, particularly concerning the development of young players. In the domain of youth sport development, one significant factor that must be considered is the perceived competence of players. This variable is closely linked to positive psychological outcomes and sustained practice. However, there is a lack of understanding about how other important developmental factors such as age, early sport specialization, players’ position and relative age affect players’ perceived competence. Therefore, the objective of this study is to explore the relationships between these developmental factors, perceived ice hockey competence and a global measure of perceived sport competence.

Methods

Data was drawn from 971 players (14.78 ± 1.61 mean age), who completed on-line questionnaires, from which we conducted path analyses involving all variables.

Results

Younger players tend to display higher perceived competence scores than older players. Additionally, players who opted to specialize earlier also reported higher perceived competence. Furthermore, forwards and defensemen had differing perceptions of their competence, which was in line with their respective roles on the ice. The study also showed relative age effects, in which players who were born earlier relative to the selection period tend to perceive themselves more advantageously in three components of perceived competence.

Discussion

Based on these findings, several recommendations are proposed for coaches and decision-makers to encourage the positive development of ice hockey players. The study highlights that ice hockey-specific competencies are influenced by various factors, such as early sport specialization, relative age effect, player age, and position.
The relationship of social support to posttraumatic growth in COVID-19 among college students after experiencing campus lockdown: the effects of belief in a just world and meaning in life
Authors: Wu Aoyu
Published: January 2024

Background

Campus lockdown orders were issued for the purpose of preventing and controlling COVID-19, which resulted in psychological problems among college students. However, the experiences they have during the pandemic may also lead to positive personal changes, including posttraumatic growth (PTG). The current study examined the mediating role of belief in a just world and meaning in life in social support and PTG during the COVID-19 campus lockdown.

Method

An online survey was conducted on 1711 college students in Hebei Province, China. Based on the survey results, a structural equation model was established.

Results

Social support positively predicted PTG. Furthermore, belief in a just world and meaning in life played a mediating role between social support and PTG respectively. Besides, social support could also predict PTG through the multiple serial mediating effect of belief in a just world and meaning in life.

Conclusion

These results indicated mechanisms by which social support influenced PTG, and this provided insights into how to promote post-traumatic growth among university students in the post-pandemic period.
The moderating role of perceived health risks on the acceptance of genetically modified food
Authors: Cabelkova Inna , Sanova Petra , Hlavacek Martin , Broz David , Smutka Lubos , Prochazka Petr
Published: January 2024

The public perspective on genetically modified foods (GMFs) has been intensely debated and scrutinized. Often, discussions surrounding GMF tend to revolve solely around the potential health risks associated with their consumption. However, it is essential to acknowledge that public perceptions of genetically modified foods are multifaceted, encompassing environmental concerns, ethical considerations, and economic implications. This paper studies the factors predicting GMF acceptance employing the representative sample of the Czech population (N = 884, aged 18–90 years, M ± SD: 48.17 ± 17.72; 53.40% women, 18.04% with higher education). The research relies on the Behavioral Change Model and the Health Belief Model. We employ hierarchical ordinal regressions to study the effects of information, environmental concerns, perceived health risks, food habits, purchasing habits, and socio-demographics on GMF acceptance. The results suggest that the (un)willingness to purchase GMF is primarily driven by the health risks - the environmental concerns were largely unimportant. The impact of information provision on GMF acceptance proved positive, suggesting information and education to be the main channels of creating public acceptance. The intrinsic interest regarding information related to GMF had an adverse impact on the perception of GMF morality. The benefits of the GMF proved unrelated to the GMF acceptance, indicating the gap in the information campaign. The research provides valuable insights for policymakers, public health professionals, and market researchers to communicate the GMF agenda effectively to the general public.
Accelerometer-measured physical activity and sample-based frailty in older women: does pattern really matter?
Authors: Li Ting , Zong Guanyang , Peng Pan , Wang Shiqiang , Cheng Bin
Published: January 2024

Background

The relationship between the patterns of physical activity (PA) and frailty, including its various subdomains, remains poorly understood. Therefore, this study aims to investigate the correlations between the patterns of physical activity and frailty and its various subdomains in community-dwelling older women.

Methods

A cross-sectional study investigated the association between physical activity and frailty in 1,099 women aged between 60 to 70 years. Triaxial accelerometers were used to measure bouted PA (a minimum duration of 10 min) and sporadic PA (a duration of <10 min). Fried's frailty phenotype was utilized to evaluate the status of frailty. Data were analyzed using logistic regression and the receiver operating characteristic (ROC) curve.

Results

Bouted moderate-to-vigorous PA (MVPA) and sporadic MVPA were associated with decreased odds of being prefrail and frail, and the optimal cutoff values were 6 and 19.7 for the prefrail stage and 6.6 and 19.4 min/day for the frail stage, respectively. Bouted light PA (LPA) was associated with decreased odds of being prefrail, and the optimal cutoff value was 170.2 min/day. Additionally, bouted and sporadic MVPA were associated with decreased odds of being slow and their optimal cutoff values were 5 and 19.1 min/day, respectively. Sporadic MVPA was associated with decreased odds of exhaustion, and the cutoff was 19.7 min/day. Bouted MVPA and LPA were associated with decreased odds of having low PA, and the cutoff values were 4.4 and 163.2 min/day, respectively.

Conclusion

Any MVPA, regardless of bout duration, could be used as a suitable PA program to improve and prevent frailty in older women, such as bouted MVPA (4–5 times/week) or sporadic MVPA (20 min/day). The improvement effect of bouted and sporadic MVPA on the frailty of older people may not be affected by the subdomain. Additionally, bouted LPA was suitable for the management of prefrailty.
Risk factors for pediatric intoxications in the prehospital setting. A geospatial survey
Authors: Kienbacher Calvin Lukas , Wei Guixing , Rhodes Jason M. , Herkner Harald , Roth Dominik , Williams Kenneth A.
Published: January 2024

Background

Socioeconomic factors and the COVID-19 pandemic influence children’s physical and mental health. We aimed to investigate the association between a census tract’s median household income [MHI in United States Dollars ($)] and pediatric intoxications in Rhode Island, the smallest state in the United States of America. Geographical hotspots, as well as interactions with the COVID-19 pandemic, should be identified.

Methods

This study is a retrospective analysis of ambulance calls for pediatric (<18 years) intoxication in Rhode Island between March 1st, 2018, and February 28th, 2022. March 1st, 2020 was considered the beginning of the COVID-19 pandemic. Prehospital data were joined with information from the United States Census Bureau. The census tracts’ case counts and MHI were examined using Poisson regression. Geographical clusters were identified with the Global Moran’s I and local indicators of spatial association tests in ArcGIS Pro (Esri Corporation, Redlands, CA).

Results

Inclusion criteria were met by 208 incidents (48% female, median age 16 (IQR 15 to 17) years). The regression model showed a 0.6% increase (IRR 1.006, 95% CI [1.002, 1.01], p = 0.003) in pediatric intoxications for every $ 1,000 increase in MHI. Interaction analysis showed that the effect of MHI was less pronounced during the pandemic (IRR 0.98, 95% CI [0.964, 0.997], p = 0.02). Thirty-four (14%) of the 244 census tracts contributed to geographical clusters, which changed after the onset of the pandemic.

Conclusion

Higher median household income could be a risk factor for pediatric intoxications. Geographical hotspots changed with the pandemic.
Association between periodontal health status and quality of life: a cross-sectional study
Authors: Al-Bitar Kinan M. , Garcia Jeffrey M. , Han Shengtong , Guentsch Arndt
Published: January 2024

Introduction

Attachment loss due to periodontal diseases is associated with functional limitations as well as physical pain and psychological discomfort, which may lead to a reduced quality of life. The purpose of this study is to determine if the oral health status, specifically the periodontal status, influences oral health–related quality of life.

Materials and methods

Survey data were collected in a US dental school clinical setting in a cross-sectional study. Quality of life related to oral health was assessed with the Oral Health Impact Profile-49 (OHIP-49). In addition, DMFT index, periodontal status, and health literacy scores (dental and medical health literacy) were recorded, and the data of n = 97 subjects were statistically analyzed.

Results

The DMFT index of the study population was 14.98 ± 6.21 (D: 4.72 ± 4.77; M: 3.19 ± 3.46; F: 7.12 ± 4.62). Of the subjects, 44% were identified as periodontitis cases. These periodontitis cases demonstrated significantly higher OHIP-49 scores (66.93 ± 30.72) than subjects without signs of periodontal diseases (NP) (32.40 ± 19.27, p < 0.05). There was also a significant difference between NP patients and patients with gingivitis (66.24 ± 46.12, p < 0.05). It was found that there was a statistically significant difference between Stage 3 (severe) periodontitis and periodontal health (p = 0.003). Pearson correlations were completed, and positive relationships were found with OHIP-49 and DMFT (0.206, p < 0.05), and periodontal risk self-assessment (0.237, p < 0.05). Age [odds ratio (OR) 4.46], smoking (OR 2.67), and the presence of mobile teeth (OR 2.96) are associated with periodontitis.

Conclusions

Periodontal diseases may negatively impact the oral health–related quality of life. Patients suffering from periodontitis also showed more missing teeth, which might influence function. Age and smoking are associated with a higher prevalence of periodontitis. A good general health literacy was no guarantee for having an adequate oral literacy.
Climatology of atmospheric solar tidal mode effects on ionospheric F2 parameters over the American sector during solar minimum between cycles #23 and #24
Authors: Santos A. M. , Yang G. , Pimenta A. A. , Brum C. G. M. , Batista I. S. , Sobral J. H. A. , Andrioli V. F. , Batista P. P. , Abdu M. A. , Souza J. R. , Manoharan P. K. , Wang C. , Li H. , Liu Z.
Published: January 2024

This work presents the contribution of solar atmospheric tides (diurnal, semidiurnal, and terdiurnal modes) to the variability of the parameters critical frequency (foF2) and peak height of the F2-layer (hmF2) in the American sector during the transition of solar cycles #23 and #24, a period considered one of the lowest solar activities of the modern era. The Digisonde data available in the GIRO data center were analyzed (12 stations), and the solar tide modes were evaluated regarding their amplitude, latitude, and seasonal dependence. The results showed that the hmF2 and foF2 strongly depend on latitude and seasonality, being more intense in the stations located in the south hemisphere. The same behavior is seen for the tidal amplitude fitted in these parameters, except for hmF2 diurnal tide, which is more intense at latitudes farther from the equator. Moreover, the seasonal variability of the amplitude of hmF2 in most cases presented an annual and semiannual component. A terannual component was also observed in 8 h tide mode in the height and frequency parameters. Likewise, what was observed in foF2, the variability in the mean amplitude and different modes of tides of hmF2 are higher over the sectors located in the southern hemisphere.
nLCA in bakery food products: state of the art and urgent needs
Authors: Cassarino Martina , Giuberti Gianluca , Morelli Lorenzo , Trezzi Marco , Pelattieri Andrea , Manicardi Loris , Scaglia Pietro
Published: January 2024

This study analyzes the nutritional life cycle assessment (LCA) of bakery products and the current state of the art. The analysis focuses on (1) the importance of applying a methodology, such as LCA, in a general way and the division into different stages considering the UNI EN ISO; (2) the development of nutritional LCA; (3) the difference between functional units in LCA and nutritional LCA; and (4) the different nutritional LCA approaches. The study emphasizes the lack of nutritional LCA studies regarding the bakery category, underlining the urgent need for this type of investigation concerning this specific food sector.
Entropia polityczna w przestrzeni międzynarodowej a czynniki powstrzymujące zwiększanie politycznego nieładu i postępowanie dezintegracji. Zarys problemu
Authors: Obacz Piotr
Published: January 2024

The aim of the article is to define and catalog the factors preventing political entropy in an international realm – natural tendency of increasing of disorder and progressing of disintegration in global scale. In the first part of the paper, the author extensively referred on how the second law of thermodynamics – the law of entropy are used by social scientists for explanation of phenomena of their interest, and on the basis of available scientific literature, the metaphor of political entropy was formulated. Subsequently, in the second part of the article, this metaphor was used as a framework for identification, highlighting and classification of those factors, which – in the author’s opinion – significantly contribute to the slowdown or stopping entropy in an international realm. In the commentaries and conclusions, those factors were interpreted from the institutional perspective, stressing the importance of institutionalization for regulation and stabilization of international relations, and for creation of international order – the anti-thesis of political entropy.
Analiza działań na rzecz zwiększenia frekwencji przewidzianych w nowelizacji Kodeksu wyborczego z 26 stycznia 2023 r.
Authors: Buczkowski Łukasz
Published: January 2024

The extensive amendment to the Electoral Code made by the Act of January 26, 2023 – among other solutions – introduced instruments to facilitate voters’ access to polling stations, increasing the turnout level. The aim of the article is to present the adopted solutions and their assessment, made on the background of the legislative process accompanying the adoption of the act. The conducted analysis allows to assume that the discussed solutions do not take into account the interests of all entitled persons to an equal extent, ignore the consistently reported proposals of changes affecting the increase in attendance and imply organizational difficulties due to the moment of their introduction.
O zwoływaniu posiedzeń Sejmu i Senatu RP
Authors: Pastuszko Grzegorz
Published: January 2024

The subject of this article is the issue of legal mechanisms for convening meetings of the Sejm and Senate of the Republic of Poland. The author presents and dogmatically analyzes the provisions regulating the manner of meetings of both chambers, both by decision of their Speakers and by the President. At the same time, he strives to remove the interpretative doubts that appear here and at the same time puts forward de lege ferenda postulates that improve today’s solutions. His considerations are comprehensive and show all the problems that constitute the title topic. Against this background, the main thesis of the study emerges, which states that although the existing mechanism for convening chamber meetings is basically constructed correctly, it partially requires normative modifications.
Rola sądów administracyjnych w zapewnieniu ochrony praw dzieci par jednopłciowych (w kontekście prawa europejskiego)
Authors: Kalisz Anna , Chmielarz-Grochal Anna
Published: January 2024

The role of courts in the protection of individual and the so-called judicial lawmaking are theoretical issues of a major importance for legal practice (law application), as they concern the answer to the question of what a judge when the statutory provisions, in the opinion of the court, are outdated or insufficient in relation to the factual situation being resolved, due to ongoing alterations in social relations. The aim of the study is to point out the role of administrative courts in protecting the rights of children of same-sex couples. Contemporary phenomena operating on a European scale, such as open borders and migrations, pluralism of lifestyles, or the development in infotech and biotech (also medical technologies), are reflected in legal relationships regulated by various branches of law, including the norms regulating cases falling within the scope of cognition of administrative courts. They are also, inter alia, a source of problems in the title area related to the interpretation of such norms. Case-law can play an important role in both dynamically interpreting the law within social realities, unifying practice and rising the awareness of rights protection. The title subject is presented in the light of European law – primarily in the light of standards and principles of law, the sources of which are: traditions of European states and national law, inter- and supranational regulations and case-law of the European Court of Human Rights (ECHR) and the Court of Justice of the European Union (CJEU). It is worth noting that, as far as EU law is concerned, there has been no harmonisation or unification at the community (or Convention) level in this area due to lack of delegation the relevant competences to the European Union by the Member States. According to the principle of conferral, the Union can only act within the scope of its competence and has only as much competence as the Member States have conferred on it. Thus, all matters not explicitly indicated as EU competences remain under the autonomous regulation of the Member States. However, these title matters fall – indirectly – within the scope of the norms provided for by the Convention for the Protection of Human Rights and Fundamental Freedoms (European Convention on Human Rights – ECHR). The paper shows that administrative courts – which as a rule are to pass conservative and formalistic judgements – are able to refer to the value of flexibility in the law application, when it is necessary to grant protection to the rights of children of same-sex couples.
Jednoizbowość słowackiego parlamentu i propozycje zmiany jego struktury
Authors: Pytlik Bogusław
Published: January 2024

The article highlights the formation of Slovakia’s highest representative bodies from the mid-19th century to the second half of the 20th century. The article then goes on to describe the process of drafting the Constitution of the Slovak Republic of 1 September 1992 and the importance of the fundamental structure of the parliament and the reasons why the authors of the final draft of the constitution, as well as the MPs who adopted it, turned out to be supporters of unicameralism. The main focus of the deliberations is devoted to the proposals to establish a second chamber of the Slovak Parliament, which were put forward mainly between the years 2000 and 2008. The basic solutions contained in the drafts authored by Slovak political parties, individual politicians, non-governmental organisations or governmental documents indicate the fundamental reasons for putting forward such a concept, which, since the establishment of the Slovak Republic in 1993 until present day, has not enjoyed the interest of politicians from both the governing and opposing political parties.
Michał Masłowski Mity i symbole polityczne Europy Środkowo-Wschodniej
Authors: Skoczeń Filip
Published: January 2024

This text is a review article of Michał Masłowski’s monograph “Myths and political symbols of Central and Eastern Europe”. Masłowski’s publication presents the most widespread myths, political and national symbols of Central and Eastern Europe, along with an explanation of their origin and influence over the often turbulent centuries from the early Middle Ages to the present day. The author approaches this topic in an interdisciplinary way, trying to present what shaped nations and their culture in this part of Europe.
The Essence of Russian Imperialism in the Thought of Władysław Studnicki
Authors: Czernicki Przemysław
Published: January 2024

The subject of this article is the presentation of the essence of Russian imperialismin the thought of Władysław Studnicki. It seems that in today’s geopolitical situationtheissues related to the analysis of Russia’s expansion have become extremely importantThe author of this article assumed that the thoughts formulated on the subject by theabove-mentioned thinker remain valid today. The method used to verify the hypothesis wasa critical analysis of source texts and an aspect analysis of one of the Polish researchersof the history and political system of Russia
Drying Kinetics and Mass Transfer Characteristics of Walnut under Hot Air Drying
Authors: Man Xiaolan , Li Long , Fan Xiuwen , Zhang Hong , Lan Haipeng , Tang Yurong , Zhang Yongcheng
Published: January 2024

This study was conducted to investigate the drying kinetics and internal and external mass transfer characteristics of walnuts for an understanding of the drying mechanism. The drying characteristics, mass transfer characteristics, and color of walnut during hot air drying (HAD) were investigated under different initial moisture content (IMC) (0.35, 0.39, and 0.43 g water/g wet mass) and drying temperatures (50, 60, 70, and 80 °C). The results indicated that the IMC and drying temperature both have significant effects on the drying process of walnut, showing the higher the IMC, the longer the preheating time, the smaller the effective moisture diffusivity (Deff) and mass transfer coefficient (hm), and the longer the drying time, but reverse results for drying temperature. The values of Deff and hm for walnut ranged from 4.94 × 10−10 to 1.44 × 10−9 m2/s and 1.24 × 10−7 to 3.90 × 10−7 m/s, respectively. The values of activation energy for moisture diffusion and mass transfer ranged from 21.56 to 23.35 kJ/mol and 28.92 to 33.43 kJ/mol, respectively. Multivariate linear prediction models were also established for estimating the Deff and hm as a function of the HAD process parameters. The drying temperature has a greater effect on the walnut kernel lightness than the IMC. The Verma et al model could be used to describe the HAD process of the walnut. The findings contribute to the understanding of moisture transfer mechanisms in walnuts and have practical value for the evaluation and improvement of drying systems.
Analysis of the Interaction Mechanism between Preharvest Threshing Device and Rice at Harvesting Period Based on DEM Simulations and Bench Tests
Authors: Wang Jinwu , Guo Fangyu , Xu Yanan , Zhu Jianhua , Li Ruida , Tang Han , Zhou Wenqi , Wang Qi , Sun Xiaobo
Published: January 2024

Preharvest threshing is a harvesting method that focuses on collecting rice grains while leaving the rice straw unharvested. Investigating the interaction mechanism between the machine and rice during the operation process and its correlation with harvest losses is crucial for enhancing harvest quality. In this study, structural design and operational mechanism analysis of the combs was conducted through theoretical analysis. By extracting the relevant parameters of rice plants, a model of entire-plant rice during the harvesting period was established based on the discrete element method (DEM). Numerical simulation studies were conducted to clarify the interaction mechanism between the machinery and rice at different operating stages and under various operating parameters, as well as the impact of this interaction on operational quality. The simulation results revealed that various operating parameters had a significant impact on the sliding-cut effect between the combs and rice. A higher cylinder rotation speed enhanced the effect, whereas increased forward velocity hampered it. Additionally, the effect initially improved and then decreased with a higher threshing height. In the bench test, high-speed cameras were used to verify and further analyze the comb–rice interaction mechanism and explore the optimal working parameter combination. The results showed that at a rotation speed of 616 r/min, a forward velocity of 0.91 m/s, and a threshing height of 792 mm, the grain loss rate was 1.997%, and the impurity rate was 4.073%. The harvesting losses were effectively reduced, validating the effectiveness of the study on the interaction between the machinery and rice.
MultiWave-Net: An Optimized Spatiotemporal Network for Abnormal Action Recognition Using Wavelet-Based Channel Augmentation
Authors: Elmasry Ramez M. , Abd El Ghany Mohamed A. , Salem Mohammed A.-M. , Fahmy Omar M.
Published: January 2024

Human behavior is regarded as one of the most complex notions present nowadays, due to the large magnitude of possibilities. These behaviors and actions can be distinguished as normal and abnormal. However, abnormal behavior is a vast spectrum, so in this work, abnormal behavior is regarded as human aggression or in another context when car accidents occur on the road. As this behavior can negatively affect the surrounding traffic participants, such as vehicles and other pedestrians, it is crucial to monitor such behavior. Given the current prevalent spread of cameras everywhere with different types, they can be used to classify and monitor such behavior. Accordingly, this work proposes a new optimized model based on a novel integrated wavelet-based channel augmentation unit for classifying human behavior in various scenes, having a total number of trainable parameters of 5.3 m with an average inference time of 0.09 s. The model has been trained and evaluated on four public datasets: Real Live Violence Situations (RLVS), Highway Incident Detection (HWID), Movie Fights, and Hockey Fights. The proposed technique achieved accuracies in the range of 92% to 99.5% across the used benchmark datasets. Comprehensive analysis and comparisons between different versions of the model and the state-of-the-art have been performed to confirm the model’s performance in terms of accuracy and efficiency. The proposed model has higher accuracy with an average of 4.97%, and higher efficiency by reducing the number of parameters by around 139.1 m compared to other models trained and tested on the same benchmark datasets.
Oxidative Stress Plays an Important Role in Glutamatergic Excitotoxicity-Induced Cochlear Synaptopathy: Implication for Therapeutic Molecules Screening
Authors: Saidia Anissa Rym , François Florence , Casas François , Mechaly Ilana , Venteo Stéphanie , Veechi Joseph T. , Ruel Jérôme , Puel Jean-Luc , Wang Jing
Published: January 2024

The disruption of the synaptic connection between the sensory inner hair cells (IHCs) and the auditory nerve fiber terminals of the type I spiral ganglion neurons (SGN) has been observed early in several auditory pathologies (e.g., noise-induced or ototoxic drug-induced or age-related hearing loss). It has been suggested that glutamate excitotoxicity may be an inciting element in the degenerative cascade observed in these pathological cochlear conditions. Moreover, oxidative damage induced by free hydroxyl radicals and nitric oxide may dramatically enhance cochlear damage induced by glutamate excitotoxicity. To investigate the underlying molecular mechanisms involved in cochlear excitotoxicity, we examined the molecular basis responsible for kainic acid (KA, a full agonist of AMPA/KA-preferring glutamate receptors)-induced IHC synapse loss and degeneration of the terminals of the type I spiral ganglion afferent neurons using a cochlear explant culture from P3 mouse pups. Our results demonstrated that disruption of the synaptic connection between IHCs and SGNs induced increased levels of oxidative stress, as well as altered both mitochondrial function and neurotrophin signaling pathways. Additionally, the application of exogenous antioxidants and neurotrophins (NT3, BDNF, and small molecule TrkB agonists) clearly increases synaptogenesis. These results suggest that understanding the molecular pathways involved in cochlear excitotoxicity is of crucial importance for the future clinical trials of drug interventions for auditory synaptopathies.
Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice
Authors: Bo Tomoki , Nohara Hidekazu , Yamada Ken-ichi , Miyata Satoshi , Fujii Junichi
Published: January 2024

Bone marrow cells are the most sensitive to exposure to X-rays in the body and are selectively damaged even by doses that are generally considered permissive in other organs. Ascorbic acid (Asc) is a potent antioxidant that is reported to alleviate damages caused by X-ray exposure. However, rodents can synthesize Asc, which creates difficulties in rigorously assessing its effects in such laboratory animals. To address this issue, we employed mice with defects in their ability to synthesize Asc due to a genetic ablation of aldehyde reductase (Akr1a-KO). In this study, concentrations of white blood cells (WBCs) were decreased 3 days after exposure to X-rays at 2 Gy and then gradually recovered. At approximately one month, the recovery rate of WBCs was delayed in the Akr1a-KO mouse group, which was reversed via supplementation with Asc. Following exposure to X-rays, Asc levels decreased in plasma, bone marrow cells, and the liver during an early period, and then started to increase. X-ray exposure stimulated the pituitary gland to release adrenocorticotropic hormone (ACTH), which stimulated corticosterone secretion. Asc released from the liver, which was also stimulated by ACTH, appeared to be recruited to the bone marrow. Since corticosterone in high doses is injurious, these collective results imply that Asc protects bone marrow via its antioxidant capacity against ROS produced via exposure to X-rays and the cytotoxic action of transiently elevated corticosterone.
An Improved Cuckoo Search Algorithm under Bottleneck-Degree-Based Search Guidance for Large-Scale Inter-Cell Scheduling Optimization
Authors: Yang Peixuan , Liu Qiong , Xiong Shuping
Published: January 2024

In order to deal with problems of reduced searching efficiency and poor quality of algorithms for large-scale inter-cell scheduling problems, an improved cuckoo search algorithm under bottleneck-degree-based search guidance is proposed. A large-scale inter-cell scheduling optimization model aiming at minimizing makespan is established. A tabu search is adopted to replace the local search strategy of the cuckoo search algorithm. The bottleneck degree of a complex network model for an inter-cell scheduling problem is used to guide the design of the neighborhood structure of the tabu search. The proposed algorithm is validated by numerical examples. The results show that the convergent speed and qualities of solutions of the proposed algorithm are improved. It is verified that the proposed search guidance based on a complex network’s bottleneck degree could improve the searching ability and convergence speed of the algorithm for large-scale inter-cell scheduling optimization problems.
The Role of Emergent Technologies in the Dynamic and Kinematic Assessment of Human Movement in Sport and Clinical Applications
Authors: Edriss Saeid , Romagnoli Cristian , Caprioli Lucio , Zanela Andrea , Panichi Emilio , Campoli Francesca , Padua Elvira , Annino Giuseppe , Bonaiuto Vincenzo
Published: January 2024

Physical activity analysis assessment has been a concern throughout human history. The intersection of technological growth with sports has given rise to a burgeoning field known as sports engineering. In the 19th century, the advent of chrono-photography and pioneering marked the inception of sports performance analysis. In recent years, the noticeable developments achieved in wearable low-power electronics with wireless high interconnection capability, as a part of modern technologies, have aided us in studying sports parameters such as motor behavior, biomechanics, equipment design, and materials science, playing an essential role in the understanding of sports dynamics. This study aims to review over 250 published articles since 2018, focusing on utilizing and validating these emergent technologies in sports and clinical aspects. It is predicted that one of the next steps in sports technology and engineering development will be using algorithms based on artificial intelligence to analyze the measurements obtained by multi-sensor systems (sensor fusion) to monitor biometric and physiological parameters in performance analysis and health assessments.
The Role of Lung Density in the Voxel-Based Dosimetry of 90Y-TARE Evaluated with the Voxel S-Value (VSV) Method and Fast Monte Carlo Simulation
Authors: Capotosti Amedeo , Moretti Roberto , Vaccaro Maria , Ribeiro Cintia De Almeida , Placidi Lorenzo , Nardini Matteo , Meffe Guenda , Cusumano Davide , Zagaria Luca , De Risi Marina , Perotti Germano , Leccisotti Lucia , De Spirito Marco , Iezzi Roberto , Indovina Luca
Published: January 2024

(1) Background: In 90Y-TARE treatments, lung-absorbed doses should be calculated according to the manufacturer’s instructions, using the MIRD-scheme. This scheme is derived from the assumption that 90Y-microspheres deliver the dose in a water-equivalent medium. Since the density of the lungs is quite different from that of the liver, the absorbed dose to the lungs could vary considerably, especially at the liver/lungs interface. The aim of this work is to compare the dosimetric results obtained by two dedicated software packages implementing a water-equivalent dose calculation and a Monte Carlo (MC) simulation, respectively. (2) Methods: An anthropomorphic IEC phantom and a retrospective selection of 24 patients with a diagnosis of HCC were taken into account. In the phantom study, starting from a 90Y-PET/CT acquisition, the liver cavity was manually fixed with a uniform activity concentration on PET series, while the lung compartment was manually expanded on a CT series to simulate a realistic situation in which the liver and lungs are adjacent. These steps were performed by using MIM 90Y SurePlan. Then, a first simulation was carried out with only the liver cavity filled, while a second one was carried out, in which the lung compartment was also manually fixed with a uniform activity concentration corresponding to 10% lung shunt fraction. MIM 90Y SurePlan was used to obtain Voxel S-Value (VSV) approach dose values; instead, Torch was used to obtain MC approach dose values for both the phantom and the patients. (3) Results: In the phantom study, the percentage mean dose differences (∆D%) between VSV and MC in the first and second simulation, respectively were found to be 1.2 and 0.5% (absolute dose variation, ∆D, of 0.7 and 0.3 Gy) for the liver, −56 and 70% (∆D of −0.3 and −16.2 Gy) for the lungs, and −48 and −60% (∆D of −4.3 and −16.5 Gy) for the Liver/Lungs Edge region. The patient study reports similar results with ∆D% between VSV and MC of 7.0%, 4.1% and 6.7% for the whole liver, healthy liver, and tumor, respectively, while the result was −61.2% for the left lung and −61.1% for both the right lung and lungs. (4) Conclusion: Both VSV and MC allowed accurate radiation dose estimation with small differences (<7%) in regions of uniform water-equivalent density (i.e., within the liver). Larger differences between the two methods (>50%) were observed for air-equivalent regions in the phantom simulation and the patient study.
A System for Individual Environmental Risk Assessment and Management with IoT Based on the Worker’s Health History
Authors: Lemos Janaína , de Souza Vanessa Borba , Falcetta Frederico Soares , de Almeida Fernando Kude , Lima Tânia M. , Gaspar Pedro D.
Published: January 2024

This paper presents a monitoring system to measure dust, noise, ultraviolet radiation, illuminance, temperature, and humidity and to check the presence of flammable gases—liquefied petroleum gas (LPG), propane, hydrogen, butane, methane, and carbon monoxide. The system is composed of monitoring devices, a server to process data received from the devices and that runs a web application for employers, and a mobile application for workers to check their exposure data. During employee registration, the health history of the worker concerning common diseases and symptoms related to the monitored agents must be informed. This information is analyzed through a set of predefined rules to generate alerts that the company can consider for planning professional activities to minimize exposure to risk agents. The tests presented in this work are focused on verifying the functionalities of the web interface for employee registration, especially regarding the provision of health information, the updating of this information, and the generation of corresponding alerts. At this stage, fictitious employee information was used. The results showed that the system adequately performs the proposed functionalities, and it was concluded that the solution is viable for testing in a work environment in the future stages of development. The innovative features of this study concern the correlation between workers’ health history and harmful agents to build suggestions and alerts to guide long-term OSH-related decisions.
Co-Design of Mechanical and Vibration Properties of a Star Polygon-Coupled Honeycomb Metamaterial
Authors: Yong Jiawang , Li Wanting , Hu Xiaojun , Wan Zhishuai , Dong Yiyao , Feng Nenglian
Published: January 2024

Based on the concept of component assembly, a novel star polygon-coupled honeycomb metamaterial, which achieves a collaborative improvement in load-bearing capacity and vibration suppression performance, is proposed based on a common polygonal structure. The compression simulation and experiment results show that the load-bearing capacity of the proposed metamaterial is three times more than that of the initial metamaterial. Additionally, metal pins are attached and particle damping is applied to the metamaterial to regulate its bandgap properties; the influence of configuration parameters, including the size, number, position, and material of the metal pins, on bandgaps is also investigated. The results show that the bandgap of the proposed metamaterial can be conveniently and effectively regulated by adjusting the parameters and can effectively suppress vibrations in the corresponding frequency band. Particle damping can be used to continuously adjust the frequency of the bandgap and further enhance the vibration suppression capacity of the metamaterial in other frequency bands. This paper provides a reference for the design and optimization of metamaterials.
Four-Wheeled Vehicle Sideslip Angle Estimation: A Machine Learning-Based Technique for Real-Time Virtual Sensor Development
Authors: Napolitano Dell’Annunziata Guido , Ruffini Marco , Stefanelli Raffaele , Adiletta Giovanni , Fichera Gabriele , Timpone Francesco
Published: January 2024

In the last few decades, the role of vehicle dynamics control systems has become crucial. In this complex scenario, the correct real-time estimation of the vehicle’s sideslip angle is decisive. Indeed, this quantity is deeply linked to several aspects, such as traction and stability optimization, and its correct understanding leads to the possibility of reaching greater road safety, increased efficiency, and a better driving experience for both autonomous and human-controlled vehicles. This paper aims to estimate accurately the sideslip angle of the vehicle using different neural network configurations. Then, the proposed approach involves using two separate neural networks in a dual-network architecture. The first network is dedicated to estimating the longitudinal velocity, while the second network predicts the sideslip angle and takes the longitudinal velocity estimate from the first network as input. This enables the creation of a virtual sensor to replace the real one. To obtain a reliable training dataset, several test sessions were conducted on different tracks with various layouts and characteristics, using the same reference instrumented vehicle. Starting from the acquired channels, such as lateral and longitudinal acceleration, steering angle, yaw rate, and angular wheel speeds, it has been possible to estimate the sideslip angle through different neural network architectures and training strategies. The goodness of the approach was assessed by comparing the estimations with the measurements obtained from an optical sensor able to provide accurate values of the target variable. The obtained results show a robust alignment with the reference values in a great number of tested conditions. This confirms that the adoption of artificial neural networks represents a reliable strategy to develop real-time virtual sensors for onboard solutions, expanding the information available for controls.
The Medicinal Moroccan Plant Cladanthus arabicus as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin
Authors: Bouissane Latifa , Bailly Christian
Published: January 2024

The yellow-flowering plant Cladanthus arabicus (L.) Cass., commonly called Arabian Cladanthus or palm springs daisy, is typical of the West Mediterranean region and is particularly abundant in Morocco. The plant is used in traditional Moroccan medicine for the treatment of diabetes and other ailments. Over the past 20 years, this abundant wild plant has been neglected from a phytochemical viewpoint. For the first time, the present review provides a survey of the pharmacological properties reported from extracts of C. arabicus and from essential oils derived from the aerial parts, mainly antimicrobial, antioxidant, and anti-inflammatory properties. The main bioactive natural products are discussed, with a focus on two rare sesquiterpenes of major interest, which are abundant in the stems and leaves: the 6,12-guaianolide cladantholide and the germacranolide sintenin. These sesquiterpene lactones and their analogues are presented to highlight their properties, extraction or total synthesis, and their therapeutic benefits. They both represent convenient biosourced precursors for the synthesis of derivatives. Sintenin may be used as a starting material for the design of hemi-synthetic germacradienolide-type costunolide or parthenolide derivatives. The 6,12-guaianolide scaffold of cladantholide offers opportunities to design novel arglabin derivatives. The therapeutic potential of the neglected and under-utilized plant Cladanthus arabicus and its original phytochemicals shall be explored further.
Myogenic Differentiation and Immunomodulatory Properties of Rat Adipose-Derived Mesenchymal Stem/Stromal Cells
Authors: Koung Ngeun Sai , Shimizu Miki , Kaneda Masahiro
Published: January 2024

The myogenic differentiation potential of MSCs is a key factor in their potential use as a cell source for muscle tissue repair and regeneration. Additionally, evaluating the immunomodulatory properties of MSCs is important to highlight their potential for regulating inflammation and supporting tissue regeneration. Given the limited literature on muscle differentiation potential and immunomodulatory properties, this study aims to characterize rat ADP MSCs for treating muscle disease. We isolated MSCs from adipose tissues around the periscapular region of the rats. We used a monoculture method for the myogenic differentiation and modified the myogenic induction medium by supplementing it with the growth factors FGF, HGF, and IGF. In rat ADP MSCs, expression of the MSC-specific marker, CD90, was 87.7%, while CD44 was 42.8%. For genes involved in immunomodulation, IGF1 and TGFB1 were highly expressed, while IL6 was poorly expressed. In addition to their trilineage differentiation potential, ADP MSCs exhibited the capacity to differentiate into myogenic cell lines, as evidenced by changes in cell morphology, leading to elongated and aligned structures and the expression of the MyoD and MYOG antibodies. The study found that ADP MSCs show great clinical promise for muscle regeneration.