bluuebunny/crossref_metadata_2025 huggingface dataset:
KOMBINASI PETA PUSHIDROSAL DAN ETOPO-1 DALAM MENINGKATKAN KUALITAS BATIMETRI DI LAUT NATUNA
Authors: Oktavianty Novi Dwi , Kushadiwijayanto Arie Antasari , Nurrahman Yusuf Arief
Published: November 2022

Perairan Laut Natuna yang sebagian besar wilayahnya digunakan untuk aktivitas pelayaran membutuhkan informasi batimetri yang lebih akurat. Penelitian ini bertujuan untuk menghasilkan peta kombinasi yang lebih baik dari pada batimetri PUSHIDROSAL dan ETOPO-1 di Laut Natuna. Data yang digunakan pada penelitian ini yaitu data hasil satellite altimetry observation yaitu ETOPO-1 dan data hasil survei lapangan yang didapatkan dari PUSHIDROSAL. Analisis regresi digunakan untuk mendapatkan model keterkaitan antara peta PUSHIDROSAL dan ETOPO-1. Berdasarkan hasil analisis, diketahui bahwa model regresi yang tepat yaitu y = -4.4465+0.9680x dengan nilai koefisien korelasi (R) sebesar 0.9669 dan nilai koefisien determinasi (R2) sebesar 0.9348. Berdasarkan hasil penerapan model diketahui bahwa perbedaan kedalaman antara peta ETOPO-1 dengan peta kombinasi terdapat di area pesisir dengan rentang nilai sebesar 4 – 8 meter dan rata – rata perbedaan kedalaman sebesar 5.85 meter.
MAPPING CORAL REEF AREA OF KABUNG ISLAND USING SATELLITE IMAGERY
Authors: Sari Sherin Sastia , Nurrahman Yusuf Arief , Helena Shifa
Published: November 2022

Kabung Island is located in Bengkayang Regency, West Kalimantan. Kabung Island has a small area but has wealth and beauty that can attract tourists to come for a tour, one of which is the beauty of coral reefs. Monitoring the condition of coral reefs can be done in various ways. The utilization of remote sensing with different satellite images can monitor coral reefs in a wide area. This study aimed to create a map of the location of coral reefs on Kabung Island using medium resolution and high-resolution images. This study uses primary data, which specific methods will then process. The data are Sentinel-2 MSI Level 2A Satellite Imagery for mediumresolution image data and Birds Eye Satellite Imagery for high resolution imagery. The results of the classification of Bird Eye images obtained that the area of each class is the area of live coral on Kabung Island of 1.969 ha, dead coral of 1.1521 ha and sand or substrate of 1.7451 ha. It can be seen that the live coral class dominates in the shallow marine bottom habitat on Kabung Island, while the dead coral has the lowest area. The accuracy of test results obtained in this study was 93.4%.
Pemetaan Sebaran dan Tutupan Lamun Menggunakan Citra Satelit Sentinel-2 di Pulau Dua Kecamatan Enggano Provinsi Bengkulu
Authors: Siregar Albet Owen
Published: November 2022

Ekosistem lamun adalah tumbuhan berbunga yang hidup di perairan laut dangkal memiliki peran untuk mengurangi gelombang, menstabilkan substrat sehingga mengurangi kekeruhan, menjebak zat hara dan menjadi tempat bertelur, memijah, serta tempat bermain biota laut. Penelitian tentang sebaran dan tutupan lamun secara spasial telah dilakukan di Pulau Dua Kecamatan Enggano Provinsi Bengkulu. Tujuan dari penelitian ini adalah mengetahui luas sebaran, persentase tutupan lamun secara spasial serta mengukur akurasi peta sebaran dan tutupan lamun menggunakan citra satelit Sentinel-2. Citra yang digunakan telah dilakukan koreksi atmosferik dan koreksi kolom air. Titik pengamatan lapangan diambil sebanyak 124 titik yang disetiap titiknya diletakkan 1 transek kuadrat 10 x 10 m yang di dalamnya terdapat 9 transek kuadrat berukuran 1 x 1 m diletakkan lurus di tengah-tengah transek 10 x 10. Setiap titik pengamatan diambil titik koordinatnya diamati persen tutupan lamun. Hasil analisis data lapangan didapatkan 5 jenis lamun yaitu jenis Enhalus acoroides, Thalassia hemprichii, Syringodium isoetifolium, Cymodocea serrulata, Cymodocea rotundata. Terdapat empat kategori kepadatan lamun dari hasil klasifikasi citra, yaitu lamun jarang, lamun sedang, lamun padat dan lamun sangat padat. Analisis Citra Sentinel-2 di perairan Pulau Dua, Kecamatan Enggano, Provinsi Bengkulu menunjukan total luasan lamun sebesar 113,83 ha yang tersebar secara acak di seluruh perairan Pulau Dua dengan tutupan sangat padat 10,23ha (8,98%), lamun padat 31,23 ha (27,44%), lamun sedang 34,17 (30,03%), lamun jarang 38,20 ha (33,55%). Uji akurasi dari perbandingan hasil klasifikasi dan data lapangan (ground truth) mendapat hasil akurasi total sebesar 90%.
Identifikasi dan Keanekaragaman Mangrove di Desa Bakau Besar dan Bakau Kecil Kabupaten Mempawah Kalimantan Barat
Authors: Nuraya Tia , Zuswiryati Zuswiryati , Sari Dahlia Wulan
Published: November 2022

Penelitian ini dilaksanakan di Desa Bakau Besar dan Bakau Kecil Kabupaten Mempawah pada bulan Maret sampai April 2021. Tujuan penelitian ini adalah untuk mengetahui perubahan jenis mangrove, kerapatan dan keanekaragaman mangrove. Jumlah stasiun penelitian sebanyak 4 stasiun terdiri dari 2 stasiun di Desa Bakau Besar dan 2 stasiun di Desa Bakau Kecil, dilakukan menggunakan metode purposive sampling.  Pengamatan dilakukan dengan jarak 100 m dari bibir pantai dan jarak antar plot 100 m. Setiap stasiun dibagi menjadi 2 plot menggunakan plot persegi dengan kriteria pohon, pancang dan semai. Berdasarkan hasil penelitian didapatkan jenis mangrove yang berbeda dari penelitian sebelumnya yaitu Ceriops tagal, Bruguiera gymnorrhiza, dan Sonneratia alba yang didapat di Desa Bakau Besar sedangkan di Desa Bakau Kecil didapatkan 1 jenis mangrove yang berbeda dari penelitian sebelumnya, yaitu: Rhizophora lamarckii. Kerapatan jenis mangrove tingkatan pohon tergolong rendah sebesar 450 ind/ha di Desa Bakau Besar dan 300 ind/ha di Desa Bakau Kecil, sedangkan untuk tingkat pancang di kedua desa tergolong sedang dengan nilai 1300 ind/ha di Desa Bakau Besar dan 1400 ind/ha di Desa Bakau Kecil hanya tingkat semai yang tergolong tinggi yaitu 10.625 ind/ha di Desa Bakau Besar dan 5625 ind/ha di Desa Bakau Kecil. Sementara keanekaragaman jenis mangrove di Desa Bakau Besar tergolong sedang kecuali tingkat pancang yang tergolong rendah, sedangkan di Desa Bakau Kecil keanekaragaman jenis tergolong rendah hanya tingkat pancang tergolong sedang.
Sulfonium-Pincer Ligands Flexibility in Pt(II) Complexes
Authors: Li Ruiping , Barel Nitsan , Subramaniyan Vasudevan , Tibika Francoise , Hoffman Roy , Tulchinsky Yuri
Published: November 2022

The coordination chemistry of sulfonium cations, dormant since the early eighties, was recently revived when we reported the synthesis and characterization of the first Rh(I) and Pt(II) pincer sulfonium complexes. With the Pt(II) complexes, we had noticed the hemilability of our sulfonium pincer ligands, further explored here. This hemilability led to mononuclear bidentate complexes with both the aromatic and aliphatic sulfonium ligands. With the latter, due to its flexibility, dimeric structures of two different kinds were also allowed. The more rigid aromatic backbone adopted only a mononuclear bidentate mode, leading to a dynamic equilibrium between two asymmetric geometries. Computational study of this process predicted a local energy minimum for a pincer sulfonium-PtCl complex. However, the activation energy of its formation, as a possible intermediate, was found to be too high and indeed was not observed experimentally. Nevertheless, such PtCl complex was prepared and characterized by XRD. Although its S-Pt bond was significantly shorter than in its PtMe analog, the former was easily dissociated in coordinating solvents. It seems that lowering the dz2 orbital in this complex by strong π-back donation, renders the Pt(II) nucleus more susceptible to nucleophilic attacks. This comprehensive study should lay the ground for future applications of pincer sulfonium-Pt(II) complexes in π-acid catalysis.
Quantitative image analysis of microplastics in bottled water following Nile Red staining and fluorescence microscopy
Authors: Vitali Clementina , Peters Ruud J. B. , Janssen Hans-Gerd , Undas Anna K. , Munniks Sandra , Ruggeri Francesco Simone , Nielen Michel W. F.
Published: November 2022

The ubiquitous occurrence of microplastics (MPs) in the environment and the use of plastics in packaging materials result in the presence of MPs in the food chain and the exposure of consumers. Yet, no fully validated analytical method is available for MP quantification, which prevents the reliable estimation of the level of exposure and, ultimately, the assessment of the food safety risk associated with MP contamination. In this study, an integrated method for the analysis of MPs in bottled water based on Nile Red staining, fluorescent microscopy, and automated image analysis was developed and validated, featuring a partial interrogation of the filter, thereby boosting the analysis time. The image analysis provided the number of particles in the region of interest of the analyzed filter and the size of their major and minor axis. From these data, a rough estimation of the mass of the individual MPs, and consequently of the mass concentration in the sample, could be obtained as well. The applicability of the method for accurate MP size measurements and mass quantification was critically evaluated: the method showed to be highly sensitive in sizing MPs down to 10 µm with a limit of detection and quantification of 1.1 ppb and 3.4 ppb, respectively. Linearity and linearity range were studied between 10 ppb and 1.5 ppm resulting in a regression coefficient of (R2) of 0.99. Method precision was demonstrated by a repeatability of 11% - 12% RSD (n=7) and within-laboratory reproducibility of 16 - 29% RSD (n=21). Accuracy based on recovery was 92.6 ± 23.3 % - 97.3 ± 14.5 %. Finally, the method was successfully applied to the analysis of 15 commercial samples of bottled water with and without gas and additives.
A Quantum Information Processing Machine for Computing by Observables
Authors: Remacle Francoise , Levine Raphael D.
Published: November 2022

A quantum machine that accepts an input and processes it in parallel is described. The logic variables of the machine are not wavefunctions (qubits) but observables (i.e., operators) and its operation is described in the Heisenberg picture. The active core is a solid-state assembly of small nanosized colloidal quantum dots (QDs) or dimers of dots. The size dispersion of the QDs that causes fluctuations in their discrete electronic energies is a limiting factor. The input to the machine is provided by a train of very brief laser pulses, at least four in number. The coherent band width of each ultrashort pulse needs to span at least several and preferably all the single electron excited states of the dots. The spectrum of the QD assembly is measured as a function of the time delays between the input laser pulses. The dependence of the spectrum on the time delays can be Fourier transformed to a frequency spectrum. This spectrum of a finite range in time is made up of discrete pixels. These are the visible, raw, basic logic variables. The spectrum is analyzed to determine a possibly smaller number of principal components. A Lie-algebraic point of view is used to explore the use of the machine to emulate the dynamics of other quantum systems. An explicit example demonstrates the considerable quantum advantage of our scheme.
Weighted multivariate curve resolution – alternating least squares based on sample relevance
Authors: Ahmad Mohamad , Vitale Raffaele , Cocchi Marina , Ruckebusch Cyril
Published: November 2022

Alternating least squares, within the multivariate curve resolution framework has seen a lot of practical applications and shows its distinction with its relatively simple and flexible implementation. However, the limitations of least squares should be considered carefully when deviating from the standard assumed data structure. Within this work we highlight the effects of noise in the presence of minor components, and we propose a novel weighting scheme within the weighted multivariate curve-resolution-alternating least squares framework, to resolve it. Two simulated and one Raman imaging case is investigated, by comparing the novel methodology against standard multivariate curve resolution-alternating least squares and essential spectral pixel selection. A trade-off is observed between current methods, while the novel weighting scheme demonstrates a balance, where the benefits of the previous two methods are retained.
A catalyst acceleration platform towards realizing the energy transition
Authors: Ng Marcus Tze-Kiat , Ismail Ahmed S. M. , Hammer Alexander J. S.
Published: November 2022

The climate emergency has made it necessary to rethink our economy which relies heavily on fossil fuels. Currently, sustainable processes are too costly, but catalysis as a key enabling technology has the potential to reduce process costs to a level that makes them economically viable. In spite of that, the existing catalyst discovery paradigm depends heavily on serendipity and trial and error methods. What is urgently needed to transform the energy transition is a catalyst acceleration platform (CAP) that expedites the development of next-generation sustainable processes. To advance the field, we need to use state-of-the-art robotic and algorithmic tools to look beyond the well-established systems that dominate the current research landscape. Herein, we discuss the requirements for a successful catalyst acceleration concept and the societal impact of breakthrough catalytic materials.
Triple-negative breast cancer: new options for systemic targeted therapy. A review
Authors: Andreev Dmitry A. , Zavyalov Aleksander A.
Published: November 2022

Background. In 15-20% of patients, breast cancer is characterized by the absence or negligible expression in malignant cells of molecular therapeutic receptor targets of three key types: estrogen receptors, progesterone receptors, human epidermal growth factor receptor-2 (triple negative breast cancer TNBC). At the 2021 conferences of the American and European Societies of Clinical Oncology (ASCO and ESMO) and the San Antonio Breast Cancer Symposium (SABCS), held from December 7 to 10, important advances in new approaches to the treatment of heterogeneous TNBC cohort were announced.
Aim. To find and summarize the most striking results of clinical studies on new treatment options for TNBC patients based on the SABCS 2021.
Materials and methods. We searched the databases of the digital medical education platform MEDtalks (Hilversum, The Netherlands) and the PubMed/Medline database and analyzed the results published in 2021-2022.
Results. We systematized some results of clinical studies on drug therapy in patients with TNBC, discussed at SABCS 2021 (December 7-10, San Antonio, USA). There are now promising results from innovative clinical studies worldwide to identify the optimal approach to the selection of differentiated targeted and immunotherapies for the treatment of TNBC patients: OlympiA, KEYNOTE-522, cTRAK TN Phase II, KEYNOTE-355, NIMBUS, TROPION Phase I study.
Conclusion. Considering the molecular and histological heterogeneity of TNBC, it is reasonable to identify subgroups of patients with some quantitative and qualitative clinical characteristics for further identification of effective personalized treatment regimens. Additional clinical studies and multivariate analysis of data in the subgroups of patients with TNBC, as well as individualized treatment cases, using current methodological tools will contribute to solving the issues in the management of this category of patients.
Analysis of the complications of endocrine therapy with tamoxifen in breast cancer: clinical and pharmacogenetic aspects. Prospective pharmacogenetic cohort study
Authors: Savelyeva Marina I. , Golubenko Ekaterina O. , Sozaeva Zhannet A. , Poddubnaya Irina V. , Korennaya Vera V.
Published: November 2022

Background. Tamoxifen is the drug of choice in ER-positive breast cancer (BC) therapy for perimenopausal women and one of the endocrine therapy options for menopausal patients. The pharmacological effect of tamoxifen can be influenced by the activity of cytochrome P450 (CYP) enzymes and P-glycoprotein transporters (Pg), and the genes encoding them have broad polymorphism, affecting serum concentrations of active metabolites. This article presents the overall results of a prospective population-based study of the clinical significance of genetic polymorphism of tamoxifen metabolic enzymes and transporters in breast cancer patients after radical treatment receiving adjuvant endocrine therapy with tamoxifen in outpatient settings during 2018-2019. The study was approved by the Research Ethics Committee of the Russian Medical Academy of Continuing Professional Education.
Aim. To analyze the clinical presentation of endocrine therapy with tamoxifen in the adjuvant regimen and to assess the association of polymorphisms of genes encoding cytochrome P450 enzymes and drug transporter proteins with adverse events in BC patients.
Materials and methods. One hundred and four women with stage I-III luminal breast cancer receiving adjuvant tamoxifen were examined for the presence of CYP2D6, CYP2C, and the following CYP3A gene polymorphisms: CYP2D6*4, CYP3A5*3, CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, as well as the ABCB1 gene polymorphic marker (C3435T) encoding the P-glycoprotein. The allelic variants were identified using the real-time polymerase chain reaction; the test was performed in the Research Center of the Russian Medical Academy of Continuing Professional Education. The study material was buccal epithelium (double sampling) taken after informed consent signing.
Results. Association analysis showed the association of different genetic polymorphisms of CYP2D6, CYP3A5, CYP2C9, and ABCB1 with tamoxifen adverse drug reactions, indicating the clinical significance of these polymorphisms.
Conclusion. With the implementation of genetic testing of the studied polymorphisms into the routine clinical practice of oncologists prescribing tamoxifen and gynecologists involved in the follow-up of breast cancer patients receiving endocrine therapy in the adjuvant mode, there will be an opportunity for more effective and safer pharmacotherapy.
The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesis
Authors: Nasretdinov Ainur F. , Menshikov Konstantin V. , Sultanbaev Alexander V. , Musin Shamil I. , Sultanbaeva Nadezda I. , Men'shikova Irina A.
Published: November 2022

Knowledge of the molecular characteristics of the progression of non-small cell lung tumors currently provides the patient with the best treatment options. One of the most well-known and studied genetic abnormalities is a mutation in the EGFR gene, which makes the tumor sensitive to therapy with tyrosine kinase inhibitors. In the conditions of the existence of several therapeutic options at once, it is required to know not only the results of clinical trials, but also the fundamental features of the mechanisms of action of a particular drug. The article contains a literature review, presenting the features of the functioning of EGFR (epidermal growth factor receptor), the mechanisms of action of EGFR inhibitors of different generations (erlotinib, gefitinib, afatinib, osimertinib), generalization and analysis of the main differences between them.
Modern approaches in relapsed and refractory Hodgkin lymphoma treatment: literature review and own experience
Authors: Tsaplina Natalia S. , Valiev Timur T. , Petrova Galina D. , Kirgizov Kirill I. , Varfolomeeva Svetlana R.
Published: November 2022

An advance of Hodgkin lymphoma (HL) diagnostic and treatment protocols promoted between fatal and high-curative disease. Modern treatment programs can reach many-year survival rate in 8097% even in patients with advanced (IIIIV) HL stages and unfavorable prognostic factors pre- sence. Nevertheless, relapses and refractory (r/r) HL appears in 830% patients and depend on treatment scheme, prognostic factors and comorbi- dity. Second-line therapy (ViGePP and ICE) is a common platform for r/r HL treatment in pediatric patients, but results of 3-year relapse-free survival (RFS) not to exceed 7075%. For increase RFS rate in patients with r/r HL as combinatorial partners to schemes ViGePP and ICE add monoclonal antibodies (brentuximab vedotine) and immune chekpoint inhibitors (nivolumab), cell (auto-/allogenic stem cell transplantation) and genetically engineered (CAR-T) products. In the current issue literature and own experience in r/r HL treatment presented. It is showed, that inclusion a brentuximab vedotine in ViGePP scheme increased 3-year RFS up to 8311.2%.
Antitumor response and quality of life: is there a need to sacrifice? Clinical observation: long-term and safe control of the disease using a combination of ribociclib with letrozole. Case report
Authors: Grechukhina Katerina S. , Vorontsova Karina A. , Filonenko Daria A. , Tyutyunnik Pavel S. , Shchadrova Victoria V. , Zhukova Liudmila G.
Published: November 2022

Metastatic luminal B HER2-negative breast cancer (HR+/HER2- mBC) occupies a leading place in the global structure of morbidity and mortality among women. The current gold standard of first-line treatment is the combination of CDK4/6 inhibitors with aromatase inhibitors, among which ribociclib with letrozole is distinguished. According to the MONALEESA-2 study, the addition of ribociclib to letrozole significantly increased the median overall survival to 63.9 months, reducing the risk of death by 24%. The safety profile of the combination is manageable, and the development of adverse events led to the interruption of therapy only in 7.5% of cases. A study of the actual clinical practice of CompLEEment-1 also confirmed the safety and effectiveness of the combination. Maintaining and improving the quality of life is one of the main tasks in the treatment of patients with HR+/HER2- mBC. According to the MONALEESA-2 study, the addition of ribociclib significantly affects the maintenance of quality of life and leads to a decrease in the intensity of pain syndrome. The published data allowed us to assign a combination of ribociclib and letrozole 4 points on the ESMO-MCBS scale. The safety of long-term use of the combination in the first line of treatment illustrated by clinical observation. The patient's progression-free survival during therapy was 40 months, which significantly exceeds the data of the MONALEESA-2 and CompLEEment-1 studies. The maximum effect (partial response according to RECIST 1.1 -40%) achieved after 24 weeks and persisted for 24 months. Clinically, the patient noted a decrease in the severity of the pain syndrome after 8 weeks of therapy. Against the background of therapy, it was possible to maintain the quality of life without sacrificing antitumor efficacy.
A clinical case of the use of a new selective μ1-opioid analgesic Tafalgin in the treatment of chronic cancer pain
Authors: Abuzarova Gusal R. , Sarmanayeva Regina R. , Alekseeva Galina S. , Brazhnicova Yulia V.
Published: November 2022

In the Russian Federation, tetrapeptide tyrosyl-D-arginyl-phenylalanyl-glycine amide (Tafalgin), a novel analgesic, selective agonist of 1-opioid receptors, was developed and approved in 2022. The article presents the first experience of the successful use of Tafalgin in treating chronic pain in a cancer patient with poor tolerance to traditional opioids (tramadol, tapentadol, morphine). At baseline, pain severity, according to the Neurological Rating Scale (NRS), was 57 points at rest and up to 9 points in motion out of the maximum 10. The combination of 400 mg/day of tramadol with gabapentin and a non-steroidal anti-inflammatory drug was ineffective; 400 mg/day of tapentadol in combination with gabapentin and a non-steroidal anti-inflammatory drug also was ineffective. Morphine tablets 60 mg/day were effective (NRS score of 23), but unrelenting nausea and vomiting were unmanageable and significantly reduced quality of life. Reducing the dose of oral morphine to 20 mg/day mitigated adverse events but reduced the effectiveness of pain relief (resting NRS score of 4 points). Tafalgin 4 mg subcutaneously BID, then TID reduced the pain severity to an average daily NRS score of 1.22 over the first 3 days of treatment with no adverse events. Sleep, appetite, and physical activity improved. The patient received Tafalgin for 84 days, and she gained 5 kg due to improved nutrition during that time. The drug is comparable in efficacy to morphine and is associated with fewer adverse events. A limitation to widespread use is the availability of a formulation for subcutaneous injection only.
Approach to Ischemic Stroke
Authors: Wunder Meaghan
Published: November 2022

An approach to managing acute ischemic stroke includes recognition, investigations, treatment, and secondary prevention.  Firstly, facial drooping, limb weakness and slurred speech are some common signs that should raise the suspicion for stroke.  Upon presentation, investigations, including the national institute of health stroke scale and a CT head, should be done to rule out intracranial hemorrhage and diagnose an ischemic stroke. The treatment principles for an acute ischemic stroke focus on removing or dissolving the occlusion to maintain or reinstate perfusion of the brain.  Finally, patients suffering ischemic stroke should be admitted to the acute stroke unit and monitored for complications. Basic medical management of comorbidities should also be considered to prevent subsequent ischemic episodes. This article will explain each of these processes in more detail to help develop a basic approach to the management of an acute ischemic stroke.
Knowledge-sharing to enhance global health equity
Authors: Cheng Breagh , Chaudhry Salma , Cheng Brianna
Published: November 2022

Knowledge produced by specialized professionals can be shared to promote public understanding and decision-making. During the COVID-19 pandemic, the application, translation, and dissemination of specialized knowledge has informed global policy responses and contributed to new vaccine technologies that protect against disease. However, the pandemic has also highlighted the potential impacts that ineffective knowledge dissemination and misinformation can have on health outcomes, which can further deepen health inequities between groups. Preliminary considerations are suggested for ways to foster a culture of knowledge sharing aimed at promoting global health equity.
Prevention of Hamstring Injuries in Male Soccer Athletes
Authors: Teymourlouei Arya
Published: November 2022

Abstract 
Background: One of the most frequently injured muscle groups in soccer is the hamstring group. Soccer players have high rates of hamstring injury (HSI) due to frequent sprinting, changes in direction and similar high-risk activities. Such movements put immense stress on the hamstrings which can lead to injury. Over the last decade, at least four different HSI prevention programs and techniques have been explored in research. The purpose of this review is to assess the effectiveness of these methods. 
Methods: Studies in this review were collected using multiple database searches of PubMed. A total of six studies were selected, all either randomized controlled trials (RCTs) or cluster-RCTs. The selected trials were from various soccer leagues in Denmark, Japan, the Netherlands, and the United States.
Results: The most prevalently studied method is the Nordic hamstring exercise (NHE). Studies that utilized the NHE, either as a stand-alone or within a program, reduced the risk of HSI by 15-71%. In addition, effective programs were characterized by progressively increasing the difficulty of exercises and high compliance rates. 
Conclusion: Studies that utilized the NHE showed effectiveness in the prevention of hamstring injuries in male soccer athletes. Based on the limited research available, it is unclear whether adding other exercises to prevention programs further reduces injury risk. More research is needed to explore new and existing prevention methods in a variety of populations and regions.
HIỆU QUẢ SỬ DỤNG ĐẤT SẢN XUẤT NÔNG NGHIỆP CỦA CỘNG ĐỒNG DÂN TỘC THIỂU SỐ TẠI HUYỆN A LƯỚI, TỈNH THỪA THIÊN HUẾ
Authors: Tuyết Trần Thị Ánh , Hoàng Hồ Việt , Linh Hồ Nhật , Bình Nguyễn Văn , Phương Nguyễn Thùy
Published: November 2022

Nghiên cứu này đánh giá hiệu quả kinh tế, xã hội và môi trường trong việc sử dụng đất sản xuất nông nghiệp của đồng bào dân tộc thiểu số tại huyện A Lưới, tỉnh Thừa Thiên Huế. Số liệu được thu thập từ việc khảo sát 95 hộ gia gia đình đồng bào dân tộc thiểu số tại ba xã Quảng Nhâm, A Ngo và Hồng Thủy và phân tích thông qua các chỉ tiêu đánh giá hiệu quả sử dụng đất sản xuất nông nghiệp. Kết quả cho thấy loại hình trồng chuối đem lại hiệu quả kinh tế cao nhất. Điều này được phản ánh qua giá trị của các chỉ tiêu đánh giá hiệu quả kinh tế (tổng giá trị sản xuất GO đạt trên 87 triệu đồng/ha). Hiệu quả kinh tế từ chuối cao hơn gấp ba lần so với lúa Đông Xuân - Hè Thu và ngô cao gấp 10 lần so với sắn. Từ đó, nghiên cứu đã đề xuất ba nhóm giải pháp nhằm nâng cao hiệu quả kinh tế, xã hội và môi trường cho loại hình sử dụng đất sản xuất nông nghiệp cho huyện A Lưới trong thời gian tới.
TÌNH HÌNH SẢN XUẤT VÀ CHẾ BIẾN CÁC LOẠI TRÀ SEN (Nelumbo nucifera Gaertn.) Ở THỪA THIÊN HUẾ
Authors: Trang Nguyễn Quỳnh , Mai Nguyễn Thị
Published: November 2022

Ở Thừa Thiên Huế, trà sen ngày càng trở thành một loại thức uống được nhiều người biết đến do có nhiều giá trị về mặt sức khỏe, văn hóa và tinh thần. Nghiên cứu này điều tra tình hình sản xuất và chế biến các loại trà sen tại địa bàn. Kết quả cho thấy chín loại trà sen được sản xuất gồm trà hoa sen sấy, trà lá sen khô, trà lá sen tươi, trà lá sen túi lọc, trà hoa sen túi lọc, trà củ sen khô, trà tim sen, trà ướp hoa sen tươi và trà ướp gạo sen. Tỉnh Thừa Thiên Huế có 14 cơ sở sản xuất và kinh doanh trà sen với năm cơ sở và chín hộ gia đình, tập trung tại thành phố Huế. Đa số các hộ gia đình kinh doanh trà sen ở quy mô nhỏ và sản xuất trà theo quy trình truyền thống như ở phường Phú Hòa và huyện Phong Điền. Các cơ sở sản xuất và kinh doanh trà sen theo quy mô lớn, áp dụng khoa học công nghệ kết hợp phương pháp truyền thống tập trung tại các phường Hương Sơ, Kim Long, Thuận Thành và Phường Đúc của thành phố Huế. Kết quả cũng chỉ ra những thuận lợi, khó khăn và đề xuất một số giải pháp trong việc sản xuất và tiêu thụ trà sen ở Thừa Thiên Huế.
ẢNH HƯỞNG CỦA GIÁ THỂ VÀ PHÂN BÓN DAP ĐẾN KHẢ NĂNG SINH TRƯỞNG CỦA CÂY GIỐNG MĂNG TÂY XANH (ASPARAGUS OFFICINALIS .L) Ở GIAI ĐOẠN VƯỜN ƯƠM
Authors: Hằng Lã Thị Thu , Hà Trần Thị Triêu , Thủy Dương Thanh , Long Nguyễn Tiến
Published: November 2022

Nghiên cứu thực hiện trên hai thí nghiệm: Thí nghiệm 1 gồm bốn công thức và Thí nghiệm 2 gồm năm công thức, được bố trí độc lập theo thể thức khối hoàn toàn ngẫu nhiên với ba lần nhắc lại. Kết quả cho thấy giá thể phù hợp nhất để gieo hạt giống măng tây xanh là đất phù sa + vỏ lạc xay nhỏ + phân chuồng hoai mục (2:1:1). Tỷ lệ hạt nảy mầm 95,07 %; hạt nảy nầm sau 5 ngày gieo và sau 25 ngày cây bắt đầu ra chồi măng mới. Chiều cao cây là 57,46 cm; số cây trên bụi là 5,10; số cành lá cấp 1/cây là 16,01; số rễ/bụi là 11,70. Lượng phân DAP phù hợp nhất để bón cho cây măng tây ở giai đoạn vườn ươm là 60 kg DAP/ha (10,8 N + 27,6 P2O5/ha) và được chia làm ba lần bón. Lần đầu bón sau khi gieo hạt 20 ngày và định kỳ 20 ngày bón một lần trong thời gian 70 ngày. Cây sinh trưởng tốt; lá có màu xanh đậm; cao 56,07 cm; số cây trên bụi là 6,60; số cành lá cấp 1 trên cây là 22,63; số rễ trên bụi 16,32 và chiều dài rễ là 16,64 cm.
NUÔI VỖ CÁ LEO – Wallago attu (BLOCH & SCHNEIDER, 1801) BẰNG CÁC LOẠI THỨC ĂN KHÁC NHAU
Authors: Nghĩa Võ Đức , Tuấn Nguyễn Anh , Thành Nguyễn Đức , An Lê Thị Thu , Huy Nguyễn Văn
Published: November 2022

Nghiên cứu được thực hiện nhằm đánh giá ảnh hưởng của các loại thức ăn đến sự thành thục sinh dục của cá Leo. Thí nghiệm được thiết kế ngẫu nhiên hoàn toàn, gồm ba nghiệm thức, lặp lại ba lần: NT1 – 100% thức ăn công nghiệp; NT2 – 50% thức ăn công nghiệp + 50% cá Nục; NT3 – 100% cá Nục. Kết quả cho thấy các yếu tố môi trường nước như nhiệt độ, pH, DO và NH3 trong ao nuôi vỗ biến động không lớn và nằm trong giới hạn thích hợp cho sự phát triển và thành thục sinh dục của cá Leo. Tỷ lệ thành thục của cá Leo cao nhất ở NT3 là 75,6 ± 6,94% và thấp nhất ở NT1 là 45,6 ± 5,2% vào tháng 7. Hệ số thành thục của cá Leo cái ở NT3 (11,2 ± 1,39%) khác biệt có ý nghĩa (p < 0,05) so với NT1 (8,3 ± 1,17%) vào tháng 7. Sức sinh sản tuyệt đối và tương đối lần lượt là 74.030–131.670 trứng/cá cái và 40.744–72.725 trứng/kg cá cái. Kết quả cho thấy nuôi vỗ thành thục sinh dục cá Leo trong ao bằng thức ăn cá Nục là tốt nhất.
XÁC ĐỊNH CÁC NHÂN TỐ ẢNH HƯỞNG ĐẾN CHUYỂN ĐỔI SỬ DỤNG ĐẤT LÂM NGHIỆP TẠI HUYỆN NAM ĐÔNG, TỈNH THỪA THIÊN HUẾ
Authors: Thảo Phạm Phương , Thắng Trần Nam , Mai Nguyễn Thị Hồng , Lợi Nguyễn Văn , Trang Vũ Thị Thùy , Hằng Trần Thị Thúy
Published: November 2022

Huyện Nam Đông có diện tích đất lâm nghiệp và độ che phủ rừng lớn, nhưng tài nguyên rừng đã và đang bị suy thoái. Nghiên cứu đã tổng hợp số liệu thay đổi mục đích sử dụng rừng và theo dõi diễn biến rừng của Nam Đông trong giai đoạn 2006–2020, chồng xếp bản đồ hiện trạng rừng năm 2005, 2020 và bản đồ quy hoạch ba loại rừng ở các giai đoạn, kết hợp phỏng vấn sâu cán bộ cơ quan chức năng để thấy rõ bản chất của sự chuyển đổi đất lâm nghiệp và những vấn đề tồn tại trong quản lý bảo vệ rừng. Kết quả cho thấy, trong giai đoạn 2005–2020, diện tích rừng tự nhiên của huyện Nam Đông tăng phần lớn do sự sai khác hiện trạng; độ che phủ rừng tăng phụ thuộc vào diện tích rừng trồng và cao su; nhiều diện tích rừng tự nhiên bị chuyển đổi qua rừng trồng và diện tích rừng phòng hộ giảm. Các nhân tố ảnh hưởng đến việc chuyển đổi gồm: quy hoạch ba loại rừng; sự thay đổi cách tính, công cụ thống kê rừng; sự hỗ trợ của các chương trình trồng rừng và chuyển đổi mục đích sử dụng rừng. Nghiên cứu đề xuất sử dụng ảnh vệ tinh và phúc tra hiện trường để cập nhật và quản lý bảo vệ rừng hiệu quả hơn, thực hiện giải pháp giảm áp lực vào rừng tự nhiên và nâng cao hiệu quả rừng trồng.
Developing a Process - Oriented Feedback System for Assessing Customer Satisfaction at a Multi-Specialty Hospital in Pune City
Authors: Phalke Vivek , Shukla Kasturi
Published: November 2022

Background Customer satisfaction is a measure of how the organizationrsquos product or service performs with regard to a set of customer expectations and requirements.Objectives The primary objective of the study was to develop a system and collect the process - oriented feedback from the Out-patient Department OPD patients to analyze the areas of developmentimprovement. The secondary objective was to shift from the people-oriented feedback to process-oriented feedback.Methods The study was conducted during June-September 2021 at the Out-Patient Department of a 750- bed multi-speciality hospital in Pune city. The old feedback form used by the hospital was designed based on the designation of employee and was more person specific. We developed a new feedback system that was designed with a higher emphasis on the processes which are important for customer satisfaction which included - booking an appointment waiting time interaction with doctors nurses and technicians and quality of laboratory services.Results Using the process-oriented feedback positive feedback was mostly about the knowledge of doctors the facility the behavior of staff and nurses and the overall management. The negative feedback was related to the arrival time of doctors appointment scheduling various departments internal and external transportation. The focus was to identify the areas of improvement which may be the reason behind the customer dissatisfaction in the hospital. Conclusion Process-oriented feedback form is recommended for feedback analysis regarding customer satisfaction. This is more useful for strategic planning and decision making and establishing better quality compliance in the hospital.
Design of Vehicle Routes for Rice Distribution System in Bandung Using Simulated Annealing Algorithm
Authors: Saragih Nova Indah , Turnip Peri
Published: November 2022

VRP (vehicle routing problem) belongs to the problem of NP-hard. It makes the computation time becoming longer as the number of data increases. This statement is in accordance with previous research which solved the VRP for the rice distribution system in Bandung which consisted of 40 demand points in the form of traditional markets using the optimal method. The computational time required is 167 hours 52 minutes 38 seconds. Therefore, a heuristic method is needed to solve VRP with a more efficient computation time and an acceptable solution. The purpose of this paper is to complete the VRP by using an annealing simulation to design a rice distribution system in Bandung. Simulated annealing (SA) is a local search algorithm (meta-heuristic) that is able to get out of the local optimum. Its ease of implementation, the use of hill-climbing motions to avoid local optimal, and the convergent nature, have made SA a popular technique over the past two decades. After comparing the results to the ILP model, the computational experiments show what the SA algorithm developed in this paper is able to produce a relatively small gap in terms of total transportation cost, which is 1.26%. This paper has also succeeded in improving the previous paper by reducing the computation time to 19 seconds using the developed SA algorithm.
Redefining Gangsterism: Social Change Agents in the Black Power
Authors:   , Davis Mara
Published: November 2022

The war on gangs in Aotearoa New Zealand seems to be a never-ending battle. Sensationalist rhetoric in the media and anti-gang political discourse fosters a range of negative stereotypes about gangs and those within them, presenting them as fundamentally criminal organisations. This thesis challenges the dominant narrative on gangs by instead exploring their evolving social movement potential. Drawing on participatory action research and collaborative partnerships established within the Black Power rōpū – one of the most well-known ‘gangs’ in the country – it shows members taking up important roles as agents of social change. The research found members reinterpreting in a localised context the anti-racist symbolism of the global Black Power movement, along with adopting practices and techniques more commonly associated with social movements. Through the kōrero of members themselves, this research shows how the rōpū are actively redefining the very meaning of the terms ‘gang’ and ‘gangster’. The research not only challenges prevailing public stereotypes within Aotearoa New Zealand, but contributes to the wider field of gang research by developing a collaborative methodology that works with not on the community that is ‘the gang’ and by demonstrating the roles these collectives play in grassroots projects of social transformation.
Konsepsi Siswa pada Materi Himpunan dengan Metode CRI (Certainty of Response Index)
Authors: Sholikhah Riadhotus , Masriyah Masriyah
Published: November 2022

Penelitian ini bertujuan untuk mendeskripsikan konsepsi siswa pada materi himpunan, mendeskripsikan penyebab siswa kurang pengetahuan, dan mendeskripsikan penyebab miskonsepsi terjadi. Penelitian ini termasuk penelitian deskriptif evaluatif dengan instrumen utama peneliti sedangkan instrumen pendukung yaitu soal tes konsepsi dilengkapi dengan CRI dan pedoman wawancara. Sumber data penelitian yaitu 31 siswa kelas VII salah satu SMP negeri di Tuban. Data tes konsepsi dianalisis dengan cara mengoreksi jawaban siswa dan mengecek skala CRI yang diberikan siswa pada setiap soal. Data hasil wawancara dianalisis merujuk model Miles dan Huberman [1]. Dalam penelitian ini didapatkan hasil, siswa mempunyai konsepsi bahwa syarat tertentu dan jelas pada pengertian himpunan berarti syarat yang diberikan harus mengacu pada satu kumpulan objek saja, irisan beberapa himpunan adalah himpunan yang beranggotakan semua anggota himpunan yang diketahui, himpunan selalu mempunyai anggota, anggota yang sama dari beberapa himpunan yang diketahui bukan termasuk anggota gabungan,  komplemen dari suatu himpunan merupakan himpunan itu sendiri, himpunan bagian bukan berupa himpunan akan tetapi himpunan bagian merupakan anggota himpunan tersebut, semua anggota himpunan semesta termuat dalam himpunan yang dibahas. Hasil dari penelitian ini diharapkan dapat dijadikan guru pertimbangan untuk menentukan metode yang tepat dalam pembelajaran materi himpunan.
Kata Kunci: Konsepsi, Miskonsepsi, Kurang Pengetahuan, Himpunan
Desain Lembar Kerja Peserta Didik Materi Himpunan Berbasis Realistic Mathematics Education untuk Mendukung Pembelajaran Daring di Era Pandemi COVID-19
Authors: Ulfah Meladia Salsabila , Rejeki Sri
Published: November 2022

Kurangnya penggunaan bahan ajar dalam proses belajar mengajar di era pandemi COVID-19 mengakibatkan rendahnya motivasi belajar peserta didik dan menurunkan prestasi belajar peserta didik. Penelitian ini bertujuan  untuk mengembangkan Lembar Kerja Peserta Didik materi himpunan dengan menggunakan pendekatan Realistic Mathematics Education untuk mendukung pembelajaran daring di era pandemi COVID-19. Penelitian ini menggunakan model Borg and Gall dengan modifikasi yang terdiri dari tujuh  tahapan, yaitu penelitian dan pengumpulan data, perencanaan produk, pengembangan produk awal, validasi produk awal, merevisi produk II, uji coba lapangan, merevisi produk II. Penelitian ini melibatkan seorang ahli media, seorang ahli materi, dan sepuluh siswa di sebuah SMP negeri di Sragen, Jawa Tengah, Indonesia. Data dikumpulkan melalui kuesioner. LKPD divalidasi oleh seorang ahli materi dan seorang ahli media. Selanjutnya, respon peserta didik dievaluasi untuk menentukan kelayakan dari LKPD. Dari hasil penelitian diperoleh bahwa LKPD berbasis Realistic Mathematics Education pada materi himpunan kelas VII untuk mendukung pembelajaran daring di era pandemi COVID-19 telah valid isi, tujuan, kesesuaian pembelajaran, teknis, desain dan sangat valid dengan total rata-rata skor yang diperoleh dari validator ahli media 3,11 dan dari ahli materi memperoleh skor rata-rata 3,50 dengan kategori sangat layak. Serta pada tahap uji coba lapangan memperoleh skor rata-rata penilaian siswa 3,49 dan dikategorikan sangat layak.
Theoretical Aspects of Hedge Accounting in Non-Financial Institutions: Problematic Field and Potential Effects
Authors: Pan’kov P. I.
Published: November 2022

The paper contains the results of a study of problematic aspects and potential effects associated with the use of hedge accounting by non- financial institutions. The relevance of the study is because hedge accounting allows to ensure that income and expenses for the object and hedging instrument match but its use is the choice of the organization. Therefore, the works’s aim is to conduct a comprehensive study of the effects and problems associated with the use of hedge accounting and develop recommendations for assessing the need for usage in non-financial organizations. The author identified the following tasks for this goal achievement: studying the practice of applying hedge accounting by Russian companies; analysis of potential effects from the use of this toolkit; consideration of problematic aspects related to the application of hedge accounting; method development for determining the need for its use in non-fi institutions. The theoretical and methodological basis of the study are the provisions of IFRS and US GAAP in terms of accounting for derivatives and hedging, fair value assessment and disclosure, literature on their practical application, as well as reporting by Russian companies compiled in conformity with IFRS. In the work’s course, the author revealed that only half of the hedger companies from the considered sample apply hedge accounting. For understanding motives of organizations to use this toolkit or abandon it, the author identified the potential positive effects associated with it and problematic aspects. Also, they proposed a methodology for determining the need for its use, which would be useful for consulting companies when they provide services in risk hedging.
System Formation for Assessing the Achievement of Balanced Industrial Development in the Arctic Zone
Authors: Bogachev Yu. S. , Abdikeev N. M. , Trifonov P. V.
Published: November 2022

The purpose of the study is to consider the directions of state policy in ensuring a balanced industrial growth of the Arctic zone, and to analyze the system of criteria designed to assess the level of the region development. The latter is a set of indicators — tools for managing and coordinating economic activities. They are used to comparing the results of implementing programs to build the potential of the Arctic and planned values, and should quantitatively and qualitatively reflect the results of solving the primary tasks. The authors compared the tasks in the documents defining the strategic development of the region and the existing criteria for their implementation. They proved these criteria are imperfect and do not cover the entire spectrum of economic development categories. Since it is assumed that the Arctic zone will become a driver for the development of several manufacturing industries, the authors proposed to introduce additional indicators characterizing the contribution of industry to the development of the region’s economy. The research methodology is based on the ways of empirical research, synthesis of theoretical and practical material.
PENGARUH BAURAN PEMASARAN TERHADAP KEPUTUSAN MASYARAKAT MENGGUNAKAN PRODUK PT. UNILEVER INDONESIA DI YOGYAKARTA
Authors: Mursyid Mursyid
Published: November 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh bauran pemasaran yang terdiri dari produk, harga, jalur distribusi dan promosi, baik secara parsial maupun simultan terhadap keputusan masyarakat menggunakan Produk PT. Unilever Indonesia di Yogyakarta. Jenis penelitian yang digunakan kuantitatif. Mengingat jumlah populasi yang sulit diukur, maka sampel penelitian yang digunakan sebanyak 272 responden. Sampel diambil secara acak di beberapa lokasi. Hasil penelitian diperoleh informasi bahwa 1) Produk memiliki pengaruh yang signifikan terhadap Keputusan Masyarakat menggunakan produk PT. Unilever Indonesia; 2) Harga memiliki pengaruh yang signifikan terhadap Keputusan Masyarakat menggunakan produk PT. Unilever Indonesia; 3) Jalur distribusi memiliki pengaruh yang signifikan terhadap Keputusan Masyarakat menggunakan produk PT. Unilever Indonesia; 4) Promosi memiliki pengaruh yang signifikan terhadap Keputusan Masyarakat menggunakan produk PT. Unilever Indonesia; dan 5) Produk, harga, jalur distribusi dan promosi secara simultan memiliki pengaruh yang signifikan terhadap Keputusan Masyarakat menggunakan produk PT. Unilever Indonesia.Kata kunci: bauran pemasaran, produk, harga, jalur distribusi, promosi, keputusan masyarakat