bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase Ⅰ/Ⅱa study of cetuximab combined with fruquintinib in the previously treated RAS/BRAF wild-type metastatic colorectal cancer: Results of the CEFRU study.
Authors: Li Yong , Zhang Haibo , Huang Ling , Liu Yi-hong , Chen Xian , Qu Xin , Liu Li-rong , Hou Fangfang , Ye Yongsong
Published: June 2023

e15558

Background: The standard third-line treatment for mCRC is regorafenib, fruquintinib or TAS-102. However, the efficacy was not satisfied. Since VEGF and EGFR share the downstream signaling pathway, targeting these two pathways may have synergistic efficacy. The phase Ib trial with regorafenib combined with cetuximab have shown preliminary benefit. Fruquintinib is a small molecule highly selective VEGFR1/2/3 molecule inhibitor. Here, we evaluate the safety and efficacy of fruquintinib plus cetuximab in previously treated RAS/BRAF wild-type mCRC. Methods: This is an open-label phase I/IIa study. The primary objective was to determine the recommended phase 2 dose (RP2D) in a 3+3 dose escalation strategy in phase I and safety, grade 3/4 adverse events in phase IIa. Secondary objectives include ORR, mPFS, and mOS. Eligible patients were diagnosed as advanced RAS/BRAF wild-type CRC and had received at least two prior regimens of standard therapies. Exclude patients who have previously used other small molecule anti-vascular inhibitors. The planned number of cases is 20(including phaseⅠandⅡa). ChiCTR2000038227. Results: Between Sep, 2020 to Sep, 2022, 21 pts were enrolled including 7 patients of phase Ⅰ. The RP2D is fruquintinib 4 mg QD (3 weeks on/1 week off) plus cetuximab 500mg/m2 every two weeks, received by 17 pts. Two patient dropped out，one because of refusing treatment and another due to severe allergic reaction. 15 pts were included in the efficacy analysis and 16 pts in the safety analysis. The left side mCRC accounted for 87.5%. 68.8% have received cetuximab and 75% have received bevacizumab. The overall TRAE was 75.0%, with 25.0% grade 3 or above. The most common treatment-related AEs were acneiform rash, hypoproteinemia and dry skin (Table1). One patient had dose reduction of fruquintinib due to acneiform rash. Evaluation in 15 treated patients showed 2 cases were PR, 10 were SD and 3 were PD. DCR was 80%. mPFS was 128 days(95%CI:49.7-206.3). mOS was 229 days(95%CI: 104.0-354.0). Conclusions: Cetuximab combined with fruquintinib showed promising anti-tumor activity in CRC with resistance to at least two prior regimens. The toxicity was tolerable and no unexpected toxicities were observed (Table 1). Clinical trial information: Clinical trial information: ChiCTR2000038227 . [Table: see text]
Pembrolizumab Plus Olaparib for Patients With Previously Treated and Biomarker-Unselected Metastatic Castration-Resistant Prostate Cancer: The Randomized, Open-Label, Phase III KEYLYNK-010 Trial
Authors: Antonarakis Emmanuel S. , Park Se Hoon , Goh Jeffrey C. , Shin Sang Joon , Lee Jae Lyun , Mehra Niven , McDermott Ray , Sala-Gonzalez Núria , Fong Peter C. , Greil Richard , Retz Margitta , Sade Juan Pablo , Yanez Patricio , Huang Yi-Hsiu , Begbie Stephen D. , Gafanov Rustem Airatovich , De Santis Maria , Rosenbaum Eli , Kolinsky Michael P. , Rey Felipe , Chiu Kun-Yuan , Roubaud Guilhem , Kramer Gero , Sumitomo Makoto , Massari Francesco , Suzuki Hiroyoshi , Qiu Ping , Zhang Jinchun , Kim Jeri , Poehlein Christian H. , Yu Evan Y.
Published: June 2023

PURPOSE

There is an unmet need for therapeutic options that prolong survival for patients with heavily pretreated, metastatic castration-resistant prostate cancer (mCRPC). The phase III, open-label KEYLYNK-010 study evaluated pembrolizumab plus olaparib versus a next-generation hormonal agent (NHA) for biomarker-unselected, previously treated mCRPC.

METHODS

Eligible participants had mCRPC that progressed on or after abiraterone or enzalutamide (but not both) and docetaxel. Participants were randomly assigned (2:1) to pembrolizumab plus olaparib or NHA (abiraterone or enzalutamide). The dual primary end points were radiographic progression-free survival (rPFS) by blinded independent central review per Prostate Cancer Working Group–modified RECIST 1.1 and overall survival (OS). Time to first subsequent therapy (TFST) was a key secondary end point. Safety and objective response rate (ORR) were secondary end points.

RESULTS

Between May 30, 2019, and July 16, 2021, 529 participants were randomly assigned to pembrolizumab plus olaparib and 264 to NHA. At final rPFS analysis, median rPFS was 4.4 months (95% CI, 4.2 to 6.0) with pembrolizumab plus olaparib and 4.2 months (95% CI, 4.0 to 6.1) with NHA (hazard ratio [HR], 1.02 [95% CI, 0.82 to 1.25]; P = .55). At final OS analysis, median OS was 15.8 months (95% CI, 14.6 to 17.0) and 14.6 months (95% CI, 12.6 to 17.3), respectively (HR, 0.94 [95% CI, 0.77 to 1.14]; P = .26). At final TFST analysis, median TFST was 7.2 months (95% CI, 6.7 to 8.1) versus 5.7 months (95% CI, 5.0 to 7.1), respectively (HR, 0.86 [95% CI, 0.71 to 1.03]). ORR was higher with pembrolizumab plus olaparib versus NHA (16.8% v 5.9%). Grade ≥3 treatment-related adverse events occurred in 34.6% and 9.0% of participants, respectively.

CONCLUSION

Pembrolizumab plus olaparib did not significantly improve rPFS or OS versus NHA in participants with biomarker-unselected, heavily pretreated mCRPC. The study was stopped for futility. No new safety signals occurred.
Knowledge, Attitudes, and Resources of Frontline Oncology Support Personnel Regarding Financial Burden in Patients With Cancer
Authors: Reeder-Hayes Katherine E. , Biddell Caitlin B. , Manning Michelle L. , Rosenstein Donald L. , Samuel-Ryals Cleo A. , Spencer Jennifer C. , Smith Sophia , Deal Allison , Gellin Mindy , Wheeler Stephanie B.
Published: June 2023

PURPOSE

Financial navigation services support patients with cancer and address the direct and indirect financial burden of cancer diagnosis and treatment. These services are commonly delivered through a variety of frontline oncology support personnel (FOSP) including navigators, social workers, supportive care providers, and other clinic staff, but the perspective of FOSPs is largely absent from current literature on financial burden in oncology. We surveyed a national sample of FOSPs to understand their perspectives on patient financial burden, resource availability, and barriers and facilitators to assisting patients with cancer-related financial burden.

METHODS

We used Qualtrics online survey software and recruited participants using multiple professional society and interest group mailing lists. Categorical responses were described using frequencies, distributions of numeric survey responses were described using the median and IQR, and two open-ended survey questions were categorized thematically using a priori themes, allowing additional emergent themes.

RESULTS

Two hundred fourteen FOSPs completed this national survey. Respondents reported a high awareness of patient financial burden and felt comfortable speaking to patients about financial concerns. Patient assistance resources were commonly available, but only 15% described resources as sufficient for the observed needs. A substantial portion of respondents reported moral distress related to this lack of resources.

CONCLUSION

FOSPs, who already have requisite knowledge and comfort in discussing patient financial needs, are a critical resource for mitigating cancer-related financial burden. Interventions should leverage this resource but prioritize transparency and efficiency to reduce the administrative and emotional toll on the FOSP workforce and reduce the risk of burnout.
Dementia, Language, and Performative Force: The Case of Laughter
Authors: Barry Elizabeth
Published: June 2023

This article considers the form of dementia conversation as it features in literary memoirs, in sociological and drama research papers, and in theatrical works, exploring the intersubjective nature of such conversation, and in particular the way that laughter serves to structure it and connect those who engage in it. In losing our ability to remember, we also lose our ability to expect: to anticipate and organize future time. Those with dementia continue to be able to initiate, conduct, and organize conversations in time, however, and to regulate shared affect, via the “melody” of speech. We examine the ways in which certain forms of language and extralinguistic gestures remain in place when propositional speech is lost. These are forms of conversation that wield some illocutionary force, perform some action, in making ongoing relationships possible, functional, and even fulfilling. The discussion builds on the work of theater scholar Elinor Fuchs—her memoir about her mother's dementia, but also her writing about theater and the insights its formal modes have given her into dementia and ageing in general—to formulate an account of dementia language and the way it operates, as theater does, in the mode of Now.
Chapter One: Confucianism and Nature
Authors: Wang Ban
Published: June 2023

Environmental writers have sought to retrieve ecological wisdom from traditional Chinese thought to critique anthropocentrism, but the rediscoveries remain a disembodied discourse and ignore the relationships among humans: the political, social, and economic structures and power relations rooted in repressive hierarchy and class and gender oppression. This chapter targets political, social, and productive relations as the crucial areas for diagnosing the ills of ecological degradation. Rather than a question of how humanity as a whole stands against nature, the chapter contends that the all-too-human power relations in economy, hierarchy, and oppression are the real culprits for environmental disasters. Humanity's domination of nature is necessarily linked to the domination of other humans and of inner human nature. This perspective illuminates Kang Youwei's ecological visions in his writings about the great world community. Kang regarded nature as the foundation for culture and civilization, valorized the public principles of common goods and equality over private property, and linked women to a vital, regenerative nature. Kang heralded the eco-socialist notions of public economy, fair distribution of wealth, and wise uses of natural resources.
Chapter Nine: Artificial Intelligence, Affective Labor, and Death in Life
Authors: Wang Ban
Published: June 2023

Artificial intelligence and genetic engineering call into question the notion of the human in the humanist tradition, causing deep and subtle rifts in human-human and human-nature relations. Examining stories by Chinese sci-fi writer Hao Jingfang, this chapter argues that digital and genetic reconstruction of humanoids undermines the human self-image and blurs the boundaries between human and machine. The creation of AI humanoids cancels out as well as foregrounds the essential needs of human emotional reciprocity and the ritual of working through the trauma of sickness and death. Under capitalism, artificial intelligence creates a neoliberal performative subject, and the all-encompassing digital networks polarize society, manufacture consumer desire, and exert total control of the human mind and body. By denying death and humanly disturbing emotional qualities, artificial intelligence creates death in life.
Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system
Authors: Jubber Ibrahim , Morhardt Duncan R. , Griffin Jonathan , Cumberbatch Marcus G. , Glover Maggie , Zheng Yang , Rehman Ishtiaq , Loynes Catherine A. , Hussain Syed A. , Renshaw Stephen A. , Leach Steven D. , Cunliffe Vincent T. , Catto James W. F.
Published: June 2023

Little is known about the distal excretory component of the urinary tract in Danio rerio (zebrafish). This component is affected by many human diseases and disorders of development. Here, we have undertaken multi-level analyses to determine the structure and composition of the distal urinary tract in the zebrafish. In silico searches identified uroplakin 1a (ukp1a), uroplakin 2 (upk2) and uroplakin 3b (upk3b) genes in the zebrafish genome (orthologues to genes that encode urothelium-specific proteins in humans). In situ hybridization demonstrated ukp1a expression in the zebrafish pronephros and cloaca from 96 h post-fertilization. Haematoxylin and Eosin staining of adult zebrafish demonstrated two mesonephric ducts uniting into a urinary bladder that leads to a distinct urethral opening. Immunohistochemistry identified Uroplakin 1a, Uroplakin 2 and GATA3 expression in zebrafish urinary bladder cell layers that match human urothelial expression. Fluorescent dye injections demonstrated zebrafish urinary bladder function, including urine storage and intermittent micturition, and a urethral orifice separate from the larger anal canal and rectum. Our findings reveal homology between the urinary tracts of zebrafish and humans, and offer the former as a model system to study disease.
Return to Sports Following Shoulder Injury: Clinical Evaluation, Isokinetic, and Functional Testing
Authors: Fontánez Richard , De Jesus Kevin , Frontera Walter R. , Micheo William
Published: June 2023

The shoulder is commonly injured in overhead sports. This is associated with a high degree of mobility at the expense of stability, sports specific demands, high volume or intensity of practice and competition, biomechanical deficits, and poor technique. Following injury, the return to competition process includes nonsurgical or surgical treatment, comprehensive rehabilitation, and a structured return to sports program. The return to sports continuum is divided into phases which include return to practice of the sport, return to competition at a lower level or with reduced performance, and return to expected performance. Components of the return to sports decision include clinical evaluation of physical and psychological readiness, measurement of muscle strength using isokinetic tests, evaluation of overhead functional tasks, and progression in a supervised interval throwing program. The evidence for the effectiveness of return to sports programs following shoulder injury is limited but evolving and is an area that will merit continued investigation.
Σχεδιασμός ενός εργαλείου διερεύνησης των αντιλήψεων των σχεδιαστών δραστηριοτήτων ενός Φεστιβάλ Επιστήμης
Authors: Παππά Ελπινίκη , Κολιόπουλος Δημήτρης
Published: June 2023

Το παρόν άρθρο έχει ως στόχο να θέσει τα θεωρητικά και μεθοδολογικά θεμέλια για τη μελέτη των αντιλήψεων των σχεδιαστών σχετικά με τη διαδικασία σχεδιασμού δραστηριοτήτων που αποτελούν μέρος της δράσης εκείνης η οποία είναι γνωστή ως διαδραστική έκθεση ενός φεστιβάλ επιστήμης. Πιο συγκεκριμένα, κατ' αρχάς πρόκειται να παρουσιάσουμε ένα γενικό θεωρητικό πλαίσιο προερχόμενο από τρία ερευνητικά πεδία κοινό χαρακτηριστικό των οποίων είναι ο μετασχηματισμός της επιστημονικής γνώσης όταν αυτή αποτελεί αντικείμενο εκπαίδευσης ή/και δημόσιας κατανόησής της. Στη συνέχεια, θα επιχειρήσουμε να συγκροτήσουμε μια εκδοχή θεωρητικού πλαισίου το οποίο όμως να έχει λειτουργικό χαρακτήρα, δηλαδή, να είναι δυνατή η προσαρμογή του στις ειδικές συνθήκες της διάδοσης της επιστημονικής γνώσης σε περιβάλλον διαδραστικής έκθεσης ενός φεστιβάλ επιστήμης και, συγχρόνως, να μπορεί να οδηγεί σε μια μεθοδολογική προοπτική της αντιμετώπισης του βασικού ερευνητικού ερωτήματος. Τέλος, θα παρουσιαστεί λεπτομερώς η στρατηγική και η τεχνική διερεύνησης των αντιλήψεων των σχεδιαστών μιας τέτοιας διαδραστικής έκθεσης, ενώ θα αναδυθούν και επί μέρους ερευνητικές υποθέσεις ως προϊόντα αυτής ακριβώς της διαδικασίας τεκμηρίωσης της μεθοδολογικής στρατηγικής που θα περιγράψουμε.
The Importance of “Loss and Damage” in Supporting Climate Policy Debate
Authors: Tsipouridis Ioannis , E. Kiprotich Ngetich , Chebii Anita Jerotich , Matsagkos Nektarios , Trachanas Georgios P.
Published: June 2023

Climate change is having profound impacts on human and natural systems. In recent years, there has been growing recognition of the need to address Loss and Damage (L&D) associated with the adverse effects of climate change, particularly in developing countries that are more vulnerable to its impacts. There is a range of studies, examining the concepts, resilience, adaptation and policy options for dealing with climate change losses and damages. This article discusses the actions, research and finance needs in Loss & Damage as well as the approaches to it on some topics such as adaptation, stakeholder engagement, governance and risk transfer.
First dose COVID-19 vaccine coverage amongst adolescents and children in England: an analysis of 3.21 million patients' primary care records in situ using OpenSAFELY
Authors: Hopcroft Lisa E. , Curtis Helen J. , Brown Andrew D. , Hulme William J. , Andrews Colm D. , Morton Caroline E. , Inglesby Peter , Morley Jessica , Mehrkar Amir , Bacon Sebastian C. , Eggo Rosalind M. , Mahalingasivam Viyaasan , Parker Edward P. K. , Tomlinson Laurie A. , Bates Christopher , Cockburn Jonathan , Parry John , Hester Frank , Harper Sam , Goldacre Ben , Walker Alex J. , MacKenna Brian
Published: June 2023

Background: The coronavirus disease 2019 (COVID-19) vaccination programme in England was extended to include all adolescents and children by April 2022. The aim of this paper is to describe trends and variation in vaccine coverage in different clinical and demographic groups amongst adolescents and children in England by August 2022.

Methods: With the approval of NHS England, a cohort study was conducted of 3.21 million children and adolescents’ records in general practice in England, in situ and within the infrastructure of the electronic health record software vendor TPP using OpenSAFELY. Vaccine coverage across various demographic (sex, deprivation index and ethnicity) and clinical (risk status) populations is described.

Results: Coverage is higher amongst adolescents than it is amongst children, with 53.5% adolescents and 10.8% children having received their first dose of the COVID-19 vaccine. Within those groups, coverage varies by ethnicity, deprivation index and risk status; there is no evidence of variation by sex.

Conclusion: First dose COVID-19 vaccine coverage is shown to vary amongst various demographic and clinical groups of children and adolescents.
ANALYTICAL MODEL OF ORGANIZATION OF FREIGHT TRANSPORTATION IN COMPLEX TRANSPORT SYSTEM OF MEGALOPOLIS
Authors: Terentyev Alexey V. , Evtyukov Stanislav S. , Pirogov Yaroslav E.
Published: June 2023

The article presents an analytical model that allows designing information and analytical platforms for managing freight transportation in complex transport systems. The developed model is based on the principles of synthesis of methods for controlling the structural dynamics of complex systems and solves the problems of finding the optimal balance between the information situation of the object and the subject of design. The principles of mathematical modeling of processes on an information and analytical platform were formed, namely: the implementation of an object-oriented approach when forming an information space of possible solutions and dismemberment into subsystems and levels based on the principle of homogeneity of technology and heterogeneity of information states. On the basis of the formed approach, an information and analytical platform has been developed in the freight transportation management system, which allows you to objectively reflect the change in system variables over time for a particular process from the standpoint of multivariable forecasting, while the tools for simulating the production of solutions can be transformed in relation to a particular process, depending on the information situation corresponding to the conditions of the freight transportation process.

Purpose. Development of an analytical model for building an information and analytical platform for managing the system of road freight transportation in a large agglomeration or metropolis.

Methodology. Mathematical methods of decision theory under conditions of stochastic uncertainty, which makes it possible to develop optimal control strategies in a complex system.

Results. Mathematical model and algorithms for the organization of road freight transportation in the context of the flow of unstructured information of the external environment.

Practical implications. The transport system of a metropolis or large agglomeration, in which the indicators of its effectiveness are influenced by a large number of external and internal factors and at the same time there is a significant dynamic of the studied indicators.
THE USE OF VIRTUAL REALITY TECHNOLOGIES IN EDUCATION
Authors: Lyapunov Vladislav E. , Gilvanov Rinat G. , Vorobyov Alexander A. , Romanova Irina Yu.
Published: June 2023

Background. This article presents the results of a study of the impact of virtual reality on modern education. The comparison of traditional education and education using virtual reality is carried out.

Materials and methods. Methods of system analysis, data analysis, comparison, systems theory were used.

Results. The importance of virtual reality in education is revealed, which allows expanding the possibilities of remote interaction between people. The possibility of using virtual reality in an educational environment in order to improve the quality of assimilation of educational material, visualization of educational material is shown.

Conclusion. The article examines the role of virtual reality in modern education. It has been established that the material learned through the VR simulator is much more effective in contrast to classical teaching methods.
Uczenie się samotności na przedprożu dorosłości. Przyczynek do zrównoważonego rozumienia samotności
Authors: Dubas Elżbieta
Published: June 2023

Uczenie się samotności to kategoria poznawcza monoseologii pedagogicznej, której przestrzeń badawcza dotyczy dwóch kluczowych terminów: samotności i uczenia się. Oba rozumiane są tu szeroko. Badania empiryczne, przeprowadzone w 2021 roku na grupie 19 osób na przedprożu dorosłości (w wieku 18–25), ukazały bardzo rozległy zakres uczenia się samotności, które nie tylko przejawia się jako radzenie sobie z osamotnieniem, ale jest także poznawaniem siebie, poszukiwaniem przestrzeni dla samorealizacji w sytuacji wybieranego odosobnienia. Na uwagę zasługuje refleksyjność młodych dorosłych w okresie moratorium rozwojowego. Badania ujawniają związki ich uczenia się samotności z andragogicznymi teoriami uczenia się dorosłych, a w szczególności z teorią egzystencjalnego uczenia się. Napawa optymizmem fakt, że młodzi ludzie na przedprożu dorosłości, dodatkowo obarczeni doświadczeniem koronawirusa (2020–2021), potrafili odnaleźć się w swym osamotnieniu oraz, co szczególnie ważne, odzyskać pozytywny wymiar samotności. Wyniki badań przyczyniają się do odmitologizowania samotności rozumianej jako osamotnienie. Są też przyczynkiem do zrównoważonego rozumienia i doświadczania samotności.
Analysis of errors and prevention of complications after perosseous osteosynthesis
Authors: Bodnya A. , Butenko L. , Vadatursky M.
Published: June 2023

Distal fractures rank a special place among all fractures of the long tubular bones of the extremities. Complications are an inevitable companion of any surgical intervention, as well as an integral part of the work of every surgeon. Objective: To analyze the outcomes of treatment of distal fractures of the long bones of the extremities, to identify the causes of errors and the frequency of complications after perosseous osteosynthesis, and to outline ways for their  prevention. Patients and methods: 1723 patients with distal fractures of the long bones of the extremities and further  perosseous osteosynthesis have been under  study. Distal fractures of the humerus were registered in 647 patients, those of the femur – in 392, and the bones of the lower leg were damaged in 684. Results: The most common complication of perosseous osteosynthesis is inflammation of the soft tissues near the pins - 21.8%. Non-infectious complications (secondary displacement of fragments, contractures, impaired innervation and trophism) were observed in 18.2% of cases. Residual effects of neuritis of the radial and peroneal nerves amounted to 0.1%. In the long-term period there were 2.1% of the knee and elbow joints contractures. Conclusions: Complications observed in the process of treatment of distal fractures of long bones of the extremities with the use of perosseous osteosynthesis are not inherent this method of treatment, since they are the result of medical errors in the choice of indications for its use, violations of osteosynthesis’ technique  and postoperative management of patients, mainly in the period of minimally invasive technology of surgical intervention development.
Utilization of Seismic Data as a Tsunami Vulnerability Review
Authors: Khusnani Azmi , Jufriansah Adi , Afriyanto Mulya
Published: June 2023

This study aimed to analyze seismic data, which is then made into an infographic to map the level of tsunami hazard in the Sikka District. The research was carried out in Sikka District, East Nusa Tenggara, located between 121°55'40''-122°41'30'' east longitude and 08°22'-08°50' south latitude. The data source comes from the IRIS Earthquake Browser, and the analysis stage was carried out in two phases. The first analysis used seismic data analysis, and EQ Energy used IRIS (Incorporated Research Institutions for Seismology) data. Meanwhile, the second analysis maps the tsunami risk by determining the tsunami hazard in areas with the potential for a tsunami. Based on the analysis of seismicity data showed that Sikka District has the potential for an earthquake accompanied by a tsunami. In contrast, the results of the EQ Energy analysis caused by the December 14, 2021 earthquake were known as the value of Ehf = 6.46 × 1014 J  and EBB = 5.48 × 1015 J. The analysis of the level of tsunami susceptibility based on the tsunami run-up height in Sikka District showed that the northern coastal area of ​​Flores had various potentials, where the highest vulnerability level was in the Alok subdistrict and parts of Talibura. Meanwhile, the area with the lowest potential was the Kewapante subdistrict.
UNUTULMAYA YÜZ TUTMUŞ ÇİNİ SOBALAR VE BİR ONARIM USTASI
Authors: ELVER Hatice
Published: June 2023

Sobanın geçmişimizde çok önemli bir yeri vardır. Soba sadece ısınmak için kullanılmaz. Üzerinde çay demlenir, yemek pişirilir, ekmek kızartılır, kestane patlatılır. Bütün aile akşamları çevresinde toplanır, keyifli sohbetler yapılır. Hele ki bu bir çini sobaysa o zaman alınan zevk bir kat daha artar. Sıcaklığıyla bulunulan mekânı ısıtan çini sobalar görünümüyle de gözleri şenlendirir.

Günümüzde nadir olarak bulunan çini sobalar Bursa’nın Yeşil semtinde antika onarımı yapan Sedat Bircan ile hayat bulmaktadır. Araştırma kapsamını; Sedat Bircan’ın atölyesinde onarılan 15 adet çini soba oluşturmaktadır. Tarama yöntemiyle tespit edilen sobalar ele alınarak betimleme yapılmaya çalışılmıştır. Çininin tanımı, çini soba hakkında genel bilgi, eski ve kırık çini soba onarım aşamaları ve 100-150 yıllık Fransız ve Alman çini soba örneklerine yer verilmiştir. Ayrıca fotoğrafları çekilen çini sobaların motif, renk ve kompozisyon özellikleri açıklanmıştır. Literatür taraması sonucu elde edilen destekleyici bilgiler araştırmayı güçlendirmektedir. Çalışmada; nostaljik maksatlı kullanılmaya devam edilen, önemli bir değere sahip olan, az sayıda örneği bulunan, kaybolmaya yüz tutmuş çini sobaları yaşatmak korumak ve gelecek nesillere taşımak amaçlanmıştır.
Positive and negative square energies of graphs
Authors: Abiad Aida , De Lima Leonardo , Desai Dheer Noal , Guo Krystal , Hogben Leslie , Madrid José
Published: June 2023

The energy of a graph $G$ is the sum of the absolute values of the eigenvalues of the adjacency matrix of $G$. Let $s^+(G), s^-(G)$ denote the sum of the squares of the positive and negative eigenvalues of $G$, respectively. It was conjectured by [Elphick, Farber, Goldberg, Wocjan, Discrete Math. (2016)] that if $G$ is a connected graph of order $n$, then $s^+(G)\geq n-1$ and $s^-(G) \geq n-1$. In this paper, we show partial results towards this conjecture. In particular, numerous structural results that may help in proving the conjecture are derived, including the effect of various graph operations. These are then used to establish the conjecture for several graph classes, including graphs with certain fraction of positive eigenvalues and unicyclic graphs.
Green hydrogen as an environmentally-friendly power source
Authors: NICOLIN Bogdan Adrian , NICOLIN Ilie
Published: June 2023

Hydrogen is the most plentiful chemical element in the visible universe. The mass composition of the visible universe is approximately 74% hydrogen, 24% helium, 1% oxygen, and the rest of all other chemical elements is about 1%. Hydrogen has the symbol H and the atomic number 1. It is placed in the first position in Mendeleev's periodic table of elements, in the upper left corner. It is an easily flammable, colorless, tasteless, odorless gas, and in nature, it is found mainly in the form of the diatomic molecule, H 2. With an atomic mass unit of 1.00794, hydrogen is the lightest chemical element.
Etymologically, the word hydrogen is a combination of two Greek words hydor and gennan meaning: water producer. Hydrogen (H 2) has a very good calorific value per mass unit 143 MJ/kg which is 3.33 times more than the calorific value of kerosene or diesel fuel. Green hydrogen (clean hydrogen or renewable hydrogen) is produced by electrolysis of water (splitting of water into hydrogen and oxygen) using electricity from renewable sources such as solar energy, wind energy, seawater waves energy, or tidal power. Green hydrogen is an environmentally-friendly power source (no harmful gases). This paper presents recent documentary research by the authors on green hydrogen as an environmentally-friendly power source: for space rocket launches and for hydrogen fuel cells used in the space shuttle as electrical power generators and drinking water generators from launch to return from the space mission; as fuel for a modified turboprop engine (Rolls-Royce and easyJet); as fuel for the European Destinus aircraft using the Jungfrau technology system for a planned hypersonic aircraft using a
modified commercial afterburning engine; as fuel for modified gas turbine engines and hydrogen fuel cells to supply electrical power to supplement the gas turbine for the Airbus ZEROe aircraft, etc.
Verification of a High-Order FEM-based CFD Code using the Method of Manufactured Solutions
Authors: OLATOYINBO Seyi Festus
Published: June 2023

A high-order computational fluid dynamics (CFD) code capable of solving compressible turbulent flow problems was developed. The CFD code employs the Flowfield Dependent Variation (FDV) scheme implemented in a Finite Element Method (FEM) framework. The FDV scheme is basically derived from the Lax-Wendroff Scheme (LWS) involving the replacement of LWS’s explicit time derivatives with a weighted combination of explicit and implicit time derivatives. The code utilizes linear, quadratic and cubic isoparametric quadrilateral and hexahedral Lagrange finite elements with
corresponding piecewise shape functions that have formal spatial accuracy of second-order, third-order and fourth-order, respectively. In this paper, the results of observed order-of-accuracy of the implemented FDV FEM-based CFD code involving grid and polynomial order refinements on uniform Cartesian grids are reported. The Method of Manufactured Solutions (MMS) is applied to governing 2-D Euler and Navier-Stokes equations for flow cases spanning both subsonic and supersonic flow regimes. Global discretization error analyses using discrete 𝐿2 norm show that the spatial order-of-accuracy of the FDV FEM-based CFD code converges to the shape function polynomial order plus one, in excellent agreement with theory. Uniquely, this procedure establishes the wider applicability of MMS in verifying the spatial accuracy of a high-order CFD code.
An Empirical Case of Education Policy Implementation in Serbian VET
Authors: Caves Katherine Marie , Oswald-Egg Maria Esther
Published: June 2023

Purpose: Education policy implementation is as important as policy design. This study applies a literature-based, multi-dimensional framework for success factors and barriers to vocational education and training (VET) reform implementation in the case of a new dual VET law in Serbia. We use the framework to assess factors related to implementation, then relate these factors to actual implementation progress to determine how factors relate to progress. In this application of the framework, we examine whether implementation success requires high scores in every dimension. Methods: This is a mixed methods study. We conduct document analysis of key resources related to the structure and intention of the reform. We also statistically analyze a dataset of two rounds of interviews conducted during the pre- and early-implementation phases. These interviews include key stakeholders from the public and private sectors, and from national, regional, and local-level actors. We examine how the framework's dimensions and determinants relate to implementation progress. Results: The implementation of the law is moving forward in Serbia, making this a successful case of progress in policy implementation. Despite this progress, the factors for implementation are not all strong. We find that the content dimension of the framework is a barrier, capacity is unclear, and context, commitment, and clients—actors' engagement— drive implementation progress. Thus, although the implementation process is imperfect in its determinants, it is successfully progressing and already forming the new system. Conclusions: Based on our results we argue that—even if the framework describes factors that affect VET reform implementation—not all elements are necessary for VET reform implementation to progress. Policymakers can start without perfect implementation conditions and may benefit from striving for "good enough" across dimensions rather than perfect in any one dimension. We discuss potential mechanisms and identify pathways for future research, including moving in the direction of causal research.
Reseña de 'Maderos, chusma y orden social: Una teoría crítica del poder policial'
Authors: Rivera Beiras Iñaki
Published: June 2023

Reseña del libro 'Maderos, chusma y orden social: Una teoría crítica del poder policial', Mark Neocleous, Ed. Katakrak 2022, 266 pp.
La galeria de migdia i el brollador del claustre de la catedral de Barcelona: l’activitat del taller d’Antoni Claperós
Authors: Jardí Anguera Montserrat , Jardí Anguera Montserrat
Published: June 2023

Tenint en compte els estudis que ens precedeixen sobre el procés de construcció de les diferents galeries del claustre de la catedral de Barcelona i sobre els escultors que van intervenir en l’escultura decorativa, hem revisat la documentació que fa referència concretament al bastiment de l’ala sud i del brollador. Les fonts del nostre estudi són bàsicament els Llibres d’Obra de la catedral de Barcelona custodiats a l’Arxiu de la catedral i la mateixa escultura decorativa, conservada in situ. Aquesta revisió ens ha permès constatar la continuïtat del taller de Pere Oller, però va ser Antoni Claperós i el seu cercle de col·laboradors, amb la destacada presència per primer cop del seu fill Joan, els responsables de la finalització del claustre el 1449.
Aprendizaje-servicio: abriendo caminos de sentido desde el aprendizaje basado en retos
Authors: Hernández-Silvera Dides Iliana , Ghilardelli Mariela Alejandra , Damonte Mariana
Published: June 2023

Durante la postpandemia derivada de la COVID-19 y con la paulatina incorporación social después del aislamiento preventivo obligatorio se llevó a cabo un proyecto educativo de aprendizaje-servicio, mediante talleres virtuales de estimulación cognitiva a adultos mayores con fines a potenciar el ejercicio cerebral en beneficio del aprendizaje cotidiano. Este trabajo tiene por objetivo describir y analizar el ofrecimiento didáctico y las acciones correspondientes a la Clínica Psicopedagógica en adultos mayores, por parte del alumnado del último año de la carrera de Licenciatura en Psicopedagogía, en la Universidad Católica Argentina. La experiencia reúne la metodología de aprendizaje-servicio y el enfoque de aprendizaje basado en retos con la doble intención de desarrollar competencias en el marco de las prácticas preprofesionales y brindar un servicio según demanda. El estudio transversal descriptivo realizado estimó el impacto de la propuesta en ambos grupos. Los datos fueron recogidos mediante un muestreo por conveniencia. Participaron en la propuesta 88 adultos de grupos pastorales de Argentina y otros países de Sudamérica (Ecuador, Perú, Venezuela, Guyana, Honduras) y una participante de España (87% mujeres y 13 % hombres), entre 30 y 91 años (M= 3.22; DE= 1.4).
Single-shot quantitative phase contrast imaging based on deep learning
Authors: Lin Yu-Chun , Luo Yuan , Chen Ying-Ju , Chen Huei-Wen , Young Tai-Horng , Huang Hsuan-Ming
Published: June 2023

Quantitative differential phase-contrast (DPC) imaging is one of the commonly used methods for phase retrieval. However, quantitative DPC imaging requires several pairwise intensity measurements, which makes it difficult to monitor living cells in real-time. In this study, we present a single-shot quantitative DPC imaging method based on the combination of deep learning (DL) and color-encoded illumination. Our goal is to train a model that can generate an isotropic quantitative phase image (i.e., target) directly from a single-shot intensity measurement (i.e., input). The target phase image was reconstructed using a linear-gradient pupil with two-axis measurements, and the model input was the measured color intensities obtained from a radially asymmetric color-encoded illumination pattern. The DL-based model was trained, validated, and tested using thirteen different cell lines. The total number of training, validation, and testing images was 264 (10 cells), 10 (1 cell), and 40 (2 cells), respectively. Our results show that the DL-based phase images are visually similar to the ground-truth phase images and have a high structural similarity index (>0.98). Moreover, the phase difference between the ground-truth and DL-based phase images was smaller than 13%. Our study shows the feasibility of using DL to generate quantitative phase imaging from a single-shot intensity measurement.
Complete head cerebral sensitivity mapping for diffuse correlation spectroscopy using subject-specific magnetic resonance imaging models: errata
Authors: Wu Melissa M. , Perdue Katherine , Chan Suk-Tak , Stephens Kimberly A. , Deng Bin , Franceschini Maria Angela , Carp Stefan A.
Published: June 2023

Errata for the associated article [Biomed. Opt. Express 13, 1131 (2022)10.1364/BOE.449046] is attached.
coiaf: Directly estimating complexity of infection with allele frequencies
Authors: Paschalidis Aris , Watson Oliver J. , Aydemir Ozkan , Verity Robert , Bailey Jeffrey A.
Published: June 2023

In malaria, individuals are often infected with different parasite strains. The complexity of infection (COI) is defined as the number of genetically distinct parasite strains in an individual. Changes in the mean COI in a population have been shown to be informative of changes in transmission intensity with a number of probabilistic likelihood and Bayesian models now developed to estimate the COI. However, rapid, direct measures based on heterozygosity orFwSdo not properly represent the COI. In this work, we present two new methods that use easily calculated measures to directly estimate the COI from allele frequency data. Using a simulation framework, we show that our methods are computationally efficient and comparably accurate to current approaches in the literature. Through a sensitivity analysis, we characterize how the distribution of parasite densities, the assumed sequencing depth, and the number of sampled loci impact the bias and accuracy of our two methods. Using our developed methods, we further estimate the COI globally fromPlasmodium falciparumsequencing data and compare the results against the literature. We show significant differences in the estimated COI globally between continents and a weak relationship between malaria prevalence and COI.
Teaching students to R3eason, not merely to solve problem sets: The role of philosophy and visual data communication in accessible data science education
Authors: Ciubotariu Ilinca I. , Bosch Gundula
Published: June 2023

Much guidance on statistical training in STEM fields has been focused largely on the undergraduate cohort, with graduate education often being absent from the equation. Training in quantitative methods and reasoning is critical for graduate students in biomedical and science programs to foster reproducible and responsible research practices. We argue that graduate student education should more center around fundamental reasoning and integration skills rather than mainly on listing 1 statistical test method after the other without conveying the bigger context picture or critical argumentation skills that will enable student to improve research integrity through rigorous practice. Herein, we describe the approach we take in a quantitative reasoning course in the R3 program at the Johns Hopkins Bloomberg School of Public Health, with an error-focused lens, based on visualization and communication competencies. Specifically, we take this perspective stemming from the discussed causes of irreproducibility and apply it specifically to the many aspects of good statistical practice in science, ranging from experimental design to data collection and analysis, and conclusions drawn from the data. We also provide tips and guidelines for the implementation and adaptation of our course material to various graduate biomedical and STEM science programs.
Mechanisms of human dynamic object recognition revealed by sequential deep neural networks
Authors: Sörensen Lynn K. A. , Bohté Sander M. , de Jong Dorina , Slagter Heleen A. , Scholte H. Steven
Published: June 2023

Humans can quickly recognize objects in a dynamically changing world. This ability is showcased by the fact that observers succeed at recognizing objects in rapidly changing image sequences, at up to 13 ms/image. To date, the mechanisms that govern dynamic object recognition remain poorly understood. Here, we developed deep learning models for dynamic recognition and compared different computational mechanisms, contrasting feedforward and recurrent, single-image and sequential processing as well as different forms of adaptation. We found that only models that integrate images sequentially via lateral recurrence mirrored human performance (N = 36) and were predictive of trial-by-trial responses across image durations (13-80 ms/image). Importantly, models with sequential lateral-recurrent integration also captured how human performance changes as a function of image presentation durations, with models processing images for a few time steps capturing human object recognition at shorter presentation durations and models processing images for more time steps capturing human object recognition at longer presentation durations. Furthermore, augmenting such a recurrent model with adaptation markedly improved dynamic recognition performance and accelerated its representational dynamics, thereby predicting human trial-by-trial responses using fewer processing resources. Together, these findings provide new insights into the mechanisms rendering object recognition so fast and effective in a dynamic visual world.
Development of a dynamic prediction model for unplanned ICU admission and mortality in hospitalized patients
Authors: Placido Davide , Thorsen-Meyer Hans-Christian , Kaas-Hansen Benjamin Skov , Reguant Roc , Brunak Søren
Published: June 2023

Frequent assessment of the severity of illness for hospitalized patients is essential in clinical settings to prevent outcomes such as in-hospital mortality and unplanned admission to the intensive care unit (ICU). Classical severity scores have been developed typically using relatively few patient features. Recently, deep learning-based models demonstrated better individualized risk assessments compared to classic risk scores, thanks to the use of aggregated and more heterogeneous data sources for dynamic risk prediction. We investigated to what extent deep learning methods can capture patterns of longitudinal change in health status using time-stamped data from electronic health records. We developed a deep learning model based on embedded text from multiple data sources and recurrent neural networks to predict the risk of the composite outcome of unplanned ICU transfer and in-hospital death. The risk was assessed at regular intervals during the admission for different prediction windows. Input data included medical history, biochemical measurements, and clinical notes from a total of 852,620 patients admitted to non-intensive care units in 12 hospitals in Denmark’s Capital Region and Region Zealand during 2011–2016 (with a total of 2,241,849 admissions). We subsequently explained the model using the Shapley algorithm, which provides the contribution of each feature to the model outcome. The best model used all data modalities with an assessment rate of 6 hours, a prediction window of 14 days and an area under the receiver operating characteristic curve of 0.898. The discrimination and calibration obtained with this model make it a viable clinical support tool to detect patients at higher risk of clinical deterioration, providing clinicians insights into both actionable and non-actionable patient features.
Public interest trends for Covid-19 and alignment with the disease trajectory: A time-series analysis of national-level data
Authors: Ziakas Panayiotis D. , Mylonakis Eleftherios
Published: June 2023

Data from web search engines have become a valuable adjunct in epidemiology and public health, specifically during epidemics. We aimed to explore the concordance of web search popularity for Covid-19 across 6 Western nations (United Kingdom, United States, France, Italy, Spain and Germany) and how timeline changes align with the pandemic waves, Covid-19 mortality, and incident case trajectories. We used the Google Trends tool for web-search popularity, and “Our World in Data” on Covid-19 reported cases, deaths, and administrative responses (measured by stringency index) to analyze country-level data. The Google Trends tool provides spatiotemporal data, scaled to a range of <1 (lowest relative popularity) to 100 (highest relative popularity), for the selected search terms, timeframe, and region. We used “coronavirus” and “covid” as search terms and set the timeframe up to November 12, 2022. We obtained multiple consecutive samples using the same terms to validate against sampling bias. We consolidated national-level incident cases and deaths weekly and transformed them to a range between 0 to 100 through the min-max normalization algorithm. We calculated the concordance of relative popularity rankings between regions, using the non-parametric Kendall’s W, which maps concordance between 0 (lack of agreement) to 1 (perfect match). We used a dynamic time-warping algorithm to explore the similarity between Covid-19 relative popularity, mortality, and incident case trajectories. This methodology can recognize the similarity of shapes between time-series through a distance optimization process. The peak popularity was recorded on March 2020, to be followed by a decline below 20% in the subsequent three months and a long-standing period of variation around that level. At the end of 2021, public interest spiked shortly to fade away to a low level of around 10%. This pattern was highly concordant across the six regions (Kendal’s W 0.88, p< .001). In dynamic time warping analysis, national-level public interest yielded a high similarity with the Covid-19 mortality trajectory (Similarity indices range 0.60–0.79). Instead, public interest was less similar with incident cases (0.50–0.76) and stringency index trajectories (0.33–0.64). We demonstrated that public interest is better intertwined with population mortality, rather than incident case trajectory and administrative responses. As the public interest in Covid-19 gradually subsides, these observations could help predict future public interest in pandemic events.