bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of RERA, 2016 on The Growth of Real Estate in India
Authors: Ohri Sakshm
Published: September 2024

Investing in real estate in India is complex, involving substantial savings, extensive research, and numerous legalities. The Real Estate (Regulation and Development) Act of 2016 (RERA) has significantly improved the sector by promoting transparency, accountability, and protecting homebuyers. Historically, India's real estate evolved from traditional systems to a regulated market under British rule, with RERA further transforming the landscape, especially in regions like Gurugram. RERA mandates project registration, accurate advertising, standardized carpet area definitions, timely project completion, and efficient dispute resolution. These measures ensure buyers have reliable information and protections, making the market more trustworthy. The COVID-19 pandemic heavily impacted the sector, causing project delays and financial difficulties. Despite these challenges, the residential sector rebounded post-pandemic due to increased demand and supportive government policies. Real estate is vital to India's economy, contributing significantly to GDP and employment. It is the second-largest employment generator after agriculture, providing around 5.5 crore jobs. The sector drives urbanization and infrastructure development, supports related industries, and offers significant investment opportunities, enhancing economic stability and growth. Overall, the survey paints a positive picture of RERA’s impact on the real estate sector, particularly in terms of increasing investor confidence and enhancing transparency and accountability. However, it also underscores the need for continuous improvements in awareness, enforcement, and procedural efficiency to fully realize the potential of RERA. By addressing these challenges and implementing the suggested improvements, RERA can further strengthen its role in transforming the Indian real estate landscape and ensuring a more secure and transparent environment for both residential and commercial real estate investments.
Innovación en el diseño de viviendas sociales. Sostenibilidad de la construcción en la Comuna Sancán
Authors: Parrales Cantos Glider Nunilo , Rodríguez Segura Cinthia Piedad , Guillem Freddy Humberto , Cobos Lucio Denny Augusto , Zavala Vásquez Carlos José , Torres Parrales José Fabian
Published: September 2024

El libro presentado aborda el diseño de viviendas de interés social en la comuna de Sancán, utilizando materiales alternativos para abordar el déficit habitacional. Se emplearon materiales ecológicos y económicos en el proyecto, con el objetivo de garantizar calidad y una vida digna. Se crearon espacios funcionales y seguros, cumpliendo con normas técnicas para asegurar resistencia y calidad estética. La construcción se basó en métodos estandarizados para edificaciones, incluyendo el uso de caña guadua y varillas de hierro como alternativas económicas. La cimentación se realizó con hormigón para garantizar la seguridad de las viviendas y mejorar la calidad de vida de los residentes de bajos recursos en la zona.
Normas Tributárias, Eficácia Indutora e Recuperação Empresarial
Authors: Garzon Ribas Pedro Henrique , Codorniz Leite Pereira Roberto
Published: September 2024

O presente estudo se dedica à análise da função indutora desempenhada pelas normas tributárias que se fazem presentes na Lei de Falência e Recuperação Empresarial (Lei n. 11.101/2005), antes e especialmente após a reforma promovida pela Lei n. 14.112/2020. Considerando que as normas tributárias são um instrumento fundamental à disposição do Estado para a intervenção no domínio econômico, os efeitos indutores das normas tributárias devem se revelar em estrita adequação com os princípios norteadores da Ordem Econômica Constitucional, sob pena de inconstitucionalidade. Quando se analisa a Lei n. 14.112/2020, observa-se o emprego muito mais intensivo de normas tributárias com eficácia indutora do que no regime jurídico anterior. Na visão dos autores, apesar de algumas preocupações pontuais em relação às normas tributárias presentes na Lei n. 14.112/2020, as referidas normas se mostram em conformidade com a Ordem Econômica Constitucional, porquanto são medidas proporcionais para fomentar a recuperação e viabilização empresarial.
Prescrição Tributária como Causa de Extinção da Punibilidade nos Crimes contra a Ordem Tributária
Authors: Mayer da Costa Ude Braz Jacqueline , Gomes de Medeiros Alana
Published: September 2024

O artigo analisa os argumentos em defesa da consideração da prescrição tributária como causa extintiva da punibilidade nos crimes contra a ordem tributária frente ao sistema jurídico brasileiro. O trabalho parte do exame dos crimes contra a ordem tributária, identificando os tipos penais e suas previsões legais, bem como a possibilidade de extinção da punibilidade pelo pagamento. Posteriormente, discute-se a obrigação tributária, seus elementos e causas extintivas. Adiante, discorre-se sobre a prescrição tributária, seu prazo e efeito enquanto causa extintiva da obrigação. Após, aborda-se criticamente os fundamentos utilizados para afastar a prescrição como causa extintiva da punibilidade dos crimes contra a ordem tributária. O objetivo do trabalho é avaliar se a extinção do crédito tributário pelo fenômeno prescricional extingue também a punibilidade do crime contra a ordem tributária, considerando nessa análise se é hipótese de interpretação extensiva e/ou aplicação analógica da norma que determina a extinção da punibilidade pelo pagamento.
IOF sobre mútuo de recursos financeiros abrange contratos de conta corrente?
Authors: Schoueri Luís Eduardo , Galdino Guilherme
Published: September 2024

Este artigo tem como objetivo, sob a perspectiva jurídico-dogmática, examinar analiticamente se o legislador ordinário buscou, no art. 13 da Lei nº 9.779/1999, vincular a hipótese tributária do IOF a uma “situação jurídica” ou uma “situação de fato”, nos termos do art. 116 do Código Tributário Nacional, a fim de que se possa verificar se tal exação abrange os contratos de conta corrente. Para tanto, será examinado o art. 13 da Lei nº 9.779/1999, de modo a interpretá-lo à luz dos métodos gramatical, histórico, sistemático e teleológico. Em seguida, será cotejada a natureza do contrato de mútuo com a dos contratos de conta corrente. Uma vez constatado, de um lado, que o art. 13 da Lei nº 9.779/1999 vincula-se a uma “situação jurídica” (contratos de mútuo), nos termos do Direito Privado, e de outro, que estes não se confundem com os de conta corrente, concluir-se-á que os últimos não estão sujeitos à incidência do IOF-crédito. Daí a tese de que o art. 13 da Lei nº 9.779/1999 não pode ser estendido aos contratos de conta corrente.
Fraude à Lei no Direito Tributário
Authors: Borges Coelho de Miranda Freire André
Published: September 2024

O presente artigo analisa o instituto da fraude à lei no âmbito do planejamento tributário. Primeiramente, debruça-se sobre o conceito e a estrutura da fraude à lei, para analisar seu âmbito de aplicação. Conclui ser bastante limitada a possibilidade de emprego da figura no Direito Tributário, em razão do caráter não imperativo da prática do fato gerador e da legalidade tributária, mas admite-o fora do âmbito das normas tributárias impositivas, desde que se respeite o limite da interpretação extensiva.
Pataka: Media Informasi dalam Kegiatan Mahasiswa
Authors: Hasmawati Hasmawati
Published: September 2024

In the current era where everything is instantaneous, things can be done using the internet or online media so that something to be done can be done more effectively, such as disseminating information online is easier than disseminating information offline. Social media has become the dominant communication medium used by society and as a medium for obtaining information, including among students. In the midst of the onslaught of online media, offline media, named Pataka, still exists today. This article deals with this.
This research using a qualitative approach was carried out in Makassar City between September and December at Hasanuddin University. Those who participated in this research were 10 college students, consisting of three women and seven men, aged between 19 and 21 years, who were recruited using purposive sampling.
The findings of this research show that pataka is interpreted in relation to three aspects, namely: pataka as a visual communication tool, sacred media, representation/symbol of student body, and marker for the location of the implementation of students’ body activities. Pataka have various shapes and functions: small square pataka, large square pataka, and rectangular pataka. The small square pataka functions as a marker for activities carried out outside the campus. The large square pataka serves to place the institution's logo. Although large square pataka can be used outside or inside campus, generally large square pataka is used for stage backgrounds. Meanwhile, the rectangular pataka functions as a welcome banner. Even though in this current era the onslaught of technology is so powerful, pataka as an offline medium is still used among college students. The fundamental aspects that underlies why pataka still exists today because pataka has become part of the tradition of a student body in their institutional activities. Apart from that, the existence of pataka is also a symbol of unity and solidarity of student body members.
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Authors: Editorial Equipe
Published: September 2024

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Screening of sex-special genes in common long-arm octopus Octopus minor based on gonadal transcriptome sequencing
Authors: He Jiabei , Wang He , Liu Chao , Chen Siqing , Zhao Qiang , Ge Jianlong , Liu Yongsheng
Published: September 2024

The common long-arm octopus (Octopus minor) is a commercially important aquaculture species in East Asia, and the male octopus grows faster than the female ones, while the information about sex-regulating mechanisms in octopuses is limited. Therefore, gonadal transcriptome sequencing was performed in O. minor to reveal the molecular mechanisms of sex regulation in cephalopods. Based on the sexuality and gonad development stage, 4 groups of 12 gonad tissues were sampled, and 11 libraries were retained for bioinformatics analysis. A total of 263,749,727 clean reads were obtained. The percentage of clean reads mapped to the O. minor reference genome ranged from 77.20% to 90.59%. A total of 3936 differentially expressed genes (DEGs) were obtained between ovarian and testicular libraries by Venn diagram analysis, including 855 ovarian up-regulated and 3081 testicular up-regulated genes. Four unigenes (transcription factor Sox-8, fermentation-1, forkhead box protein L2, and ribosomal protein large 24) and one pathway (ECM-receptor interaction) were screened to be candidate molecular markers for sex determination. The reliability and accuracy of our analysis were validated via quantitative real-time PCR in 10 randomly selected DEGs. The results of our study enhanced our understanding of the molecular mechanism underlying sex determination and potentially helped to screen the bio-markers for O. minor in different sexes.
Anathema in Velsk in 1909: Perception of the Decree “On Strengthening the Principles of Religious Tolerance” of April 17, 1905
Authors: Зейферт А.А.
Published: September 2024

В статье ставится задача показать отношение к императорскому указу «Об укреплении начал веротерпимости» от 17.04.1905 г. в консервативных церковных кругах русского общества рубежа XIX–XX вв., продемонстрировать эвристические возможности делопроизводственных документов для изучения менталитета духовенства. В качестве основного источника используются неопубликованные материалы из Государственного архива Вологодской области. Автор приходит к выводу, что Вологодским архиепископом Никоном (Рождественским) указ был воспринят крайне негативно, вплоть до того, что его положения были проигнорированы архиереем при принятии им решения об анафеме. Статья написана на основе доклада, сделанного автором на VII Барсовских чтениях (Санкт-Петербургская духовная академия, 08.12.2023 г.).

The article is aimed to show the attitude to the imperial decree “On strengthening the principles of religious tolerance” of April 17, 1905 in the conservative church circles of the Russian society at the turn of the 19th–20th centuries. Another task is to demonstrate some heuristic possibilities of clerical documents for studying the mentality of the clergy. Unpublished materials from the Vologda Oblast State Archive are used as the main source. The conclusion is made that the decree was perceived extremely negatively by archbishop Nikon of Vologda (Rozhdestvensky), up to the point that he ignored its provisions, when making a decision on anathema. The article was written on the basis of the report delivered at the VIIth Barsov Readings (St. Petersburg Theological Academy, 12.08.2023).
Life of the Chernigov Diocese of the Late 19th – Early 20th Centuries on the Pages of Governor’s Reports
Authors: Борисов Н.Ю.
Published: September 2024

В любую эпоху Церковь вовлечена в общественно-политическую жизнь государства, а государство, в свою очередь, в лице представителей центральной и местной административной власти также оценивает действия членов Церкви, как духовенства, так и мирян, а также некоторые события ее жизни. Зачастую все эти аспекты находят отражение в официальной документации. Подобное происходило и в позднеимперской России. В данной статье путем сравнительного анализа выявляется информация о религиозной жизни Черниговщины в отчетах представителей местной губернской администрации в период с 1881 по 1913 гг., а также выделяются центральные темы, которые губернаторы считали достойными внимания центральной власти. Они находили отражение в отчетной документации вне зависимости от занимающего пост начальника губернии. На основании данного перечня и оценочных суждений, содержащихся в отчетах о состоянии губерний, произведена попытка определить характер взаимоотношений между церковной и светской властью, а также отношение того или иного начальника губернии к вопросам религиозной жизни населения Черниговщины.

The Church is involved in the socio-political life of the state in any era, and the state, in its turn, through representatives of the central and local administrative authorities assesses actions of church members, both clergy and laity, as well as some events in church life. All these aspects are often reflected in official documents. The same thing happened in late imperial Russia. Using comparative analysis, information about religious life of the Chernigov region has been found out in the reports of representatives of the local provincial administration in the period from 1881 to 1913. Also highlighted are the central topics the governors considered to be worthy of the attention of the central government. The topics were reflected in the reports, regardless of the person who was the head of the province. Based on this list and the evaluative judgments of the reports on the state of the provinces, an attempt is made to determine the nature of the relationship between the church and secular authorities, as well as the attitude of this or that head of the province to the issues of religious life of the population of Chernigov region.
Episcopal Ministry in the Context of the Decisions of the 1917–1918 Local Council and Anti-religious Policy of the Soviet Government
Authors: Майорова Н.С.
Published: September 2024

В статье осуществлена попытка анализа опубликованных материалов заседаний Поместного Собора 1917–1918 гг., соборных определений и результатов его работы в новых политических реалиях и условиях антирелигиозной политики. Деяния Собора отражают многодневные дискуссии, сопровождавшее их порой бурное обсуждение в процессе выработки и принятия соборных решений, а также противостояние идейных позиций и борьбу группировок при обсуждении вопросов о высшем церковном и епархиальном управлении, правовом положении Русской Православной Церкви, направлениях и перспективах государственно-церковных отношений. Ответственность за соответствие соборных определений канонам, догматам и церковному преданию, а в дальнейшем за претворение решений Поместного Собора в жизнь ложилась на епископат. Из епископата было сформировано соборное Совещание епископов. Иерархи должны были войти и в состав Высшего Церковного Совета. Многочисленные исторические источники дают убедительные доказательства того, что в 1920–1930‑е гг. епископское служение стало подвигом во имя Бога для охранения церковных законов, обеспечения единства и самого факта существования Церкви.

The article analyzes the published proceedings of the 1917–1918 Local Council, conciliar definitions and results of its work in the new political realities and conditions of anti-religious policy. The acts of the Council reflect the multi-day discussions accompanied sometimes by heated discussions in the process of drafting and adopting the conciliar decisions, as well as the confrontation of ideological stances and the struggle of groups when discussing issues of higher ecclesiastical and diocesan administration, the legal status of the Russian Orthodox Church, the directions and prospects of State — Church relations. The responsibility for the conformity of the conciliar definitions to the canons, dogmas and church tradition and then for implementation of the decisions of the Local Council in life fell on the episcopate. The Conference of Bishops was formed of the episcopate. The hierarchs were also supposed to be the members of the Supreme Church Council. Numerous historical sources provide convincing evidence that in the 1920s–1930s episcopal ministry became a feat in the name of God for the protection of the Church Laws and ensuring the unity and the very fact of the existence of the Church.
Modelo de Gestión Académica con Enfoque Sistémico para una Educación de Calidad Acorde a los Objetivos de Desarrollo Sostenible (ODS); Propuesta Metodológica y Caso De Aplicación
Authors: Parra Giovanny Javier Alarcón , Ávalos Diego Alexander Haro , Pérez Miguel Ángel Avalos , Pérez Martha Cecilia Avalos
Published: September 2024

Objetivo: el presente estudio estableció como objetivos el desarrollo de un modelo de gestión académico con aplicación de la teoría y principios del enfoque sistémico a partir de la generación de un método a aplicar; y su utilización en las áreas de la gestión académica de la Escuela Superior Politécnica de Chimborazo alineado a los Objetivos de Desarrollo Sostenible (ODS).
 
Metodología: la metodología empleada en la investigación, de enfoque descriptivo siguió dos fases, la revisión exhaustiva de la bibliografía y documentación para la compresión y elaboración de la propuesta; y la formulación de los pasos a seguir para aplicar el enfoque sistémico en la organización objeto de estudio.
 
Resultados: el desarrollo de la primera fase de la metodología de la investigación permitió aplicar la teoría del enfoque sistémico, desarrollando un método de aplicación con actividades a seguir para cumplir el propósito. También se obtuvo como resultado el Modelo de Gestión Académico para las áreas académicas de la Escuela Superior Politécnica de Chimborazo, con todos sus elementos como declaraciones, normativas aplicables, políticas y los subsistemas internos de Gestión con entradas, actividades y productos.
 
Conclusiones: el estudio permitió demostrar que el enfoque sistémico es más que un principio teórico o abstracto y su empleo en una organización es posible, llegando a proponer un método de aplicación. De la misma forma se comprobó la pertinencia del método propuesto al desarrollar el Modelo de Gestión Académico para las áreas académicas de la Escuela Superior Politécnica de Chimborazo.
ГЕОМЕТРИЯЛЫҚ ЕСЕПТЕРДІ ШЕШУДІҢ ОҢТАЙЛЫТӘСІЛДЕРІН ІЗДЕУ
Authors: Алпамыс
Published: September 2024

Currently, we are observing a lot of new phenomena occurring in the environment around us. These phenomena require any person to have new qualities. First of all, society needs people who think outside the box, make decisions based on their own thinking and offer new initiatives. Such qualities can be formed in math lessons or in extracurricular time, solvingproblems. In a geometry textbook, the solution of geometric problems is often based on a standard algorithm. This algorithm can be difficult for students.Therefore, it is necessary to find the optimal method in search of other different ways to solve geometric problems. In this article, we will find the optimalmethod by describing several methods for solving a single geometric problem. Solving a geometric problem by various methods deepens students' mathematical knowledge and develops creative abilities.
ОҚУШЫЛАРДЫҢ ЖАЗУ САУАТТЫЛЫҒЫН ЖЕТІЛДІРУДЕОРФОГРАФИЯЛЫҚ ДАҒДЫНЫ ДАМЫТУДЫҢ ЖОЛДАРЫ
Authors: Шаймкулова Аида
Published: September 2024

One of the linguistic skills taught in writing is spelling skills. Spelling skills are a very complex process. This skill involves the ability to recognize a spelling based on the phonetic structure of the word, grammatical knowledge and apply the appropriate rules. The article provides an overview of the work of scholars who have conducted research related to writing literacy, spelling skills and its development. Talking about the role and importance ofspelling skills in the educational process, a set of tasks based on the traditional system for the development of spelling skills and created through digital learningprograms is presented.
THEORETICAL AND METHODOLOGICAL REGULATORS OF THE PROBLEM OF DUAL EDUCATION FACILITATION IN THE SYSTEM OF HIGHER PROFESSIONAL EDUCATION
Authors: Baimukhambetova Botagoz , Radchenko Natalya
Published: September 2024

The article is devoted to the study of the possibilities of using facilitation technology to improve the quality of dual education, the implementation of which in the system of higher professional education is experiencing serious difficulties. On the basis of the research it is concluded that the organisation and implementation of dual education requires strategies that help to meet the interests and needs of all subjects of the educational process. At the same time, the potential of facilitation technology in improvingthe quality of dual education in pedagogical science is not disclosed. In this regard, the aim of the study is: to determine the theoretical and methodological regulators of the problem of dual education facilitation in the system of higher professional education. To achieve this goal, the methods of theoretical analysis of scientificliterature on the problem of dual education and expert assessment of international practical experience of using facilitation technology in the educational segmentwere used. As a result, the concept of "dual education facilitation" is clarified, theoretical and methodological approaches to dual education facilitation are defined, the main stages and methods of dual education facilitation are identified. The scientific significance of the research is related to the expediency of revising the existing approaches to the implementation of dual education in universities and filling it with new content on the basis of facilitation technology, taking into account the new requirements of the labour market. Determination of theoretical and methodological regulators of the problem of dual education facilitation in the system of higher professional education will allow avoiding errors in the organisation and practical implementation of this process.
Pharmacotherapy of giant cell arteritis and polymyalgia rheumatica: Prospects for the use of monoclonal antibodies to interleukin 6
Authors: Nasonov Evgeny L. , Satybaldyev Azamat M. , Otteva Elvira N. , Beketova Tatiana V. , Baranov Andrey A.
Published: September 2024

Giant cell arteritis (GCA) and polymyalgia rheumatica (RPM) are immune-mediated rheumatic disease (IMRDs), which typically develop in people over 50 years of age. Currently, GCA and PMR are considered within a single complex autoimmune-autoinflammatory pathology, defined as “GCA-PMR spectrum disease”. This was reflected in the development of general recommendations for pharmacotherapy within the framework of the “treat-to-tar get” strategy, although specific approaches to the treatment of patients with GCA and RPM differ depending on the clinical and pathogenetic characteristics of each nosological form. Glucocorticoids (GCs) are central to the treatment of GCA and RPM. Attention is drawn to the paradoxical discrepancy between the high effectiveness of GCs in the short term and the increasing severity of pathology associated with persistent inflammatory activity and the accumulation of organ damage induced by GCs in the long term, which indicates the need to improve therapy, primarily in the direction of optimizing the use of GCs. New opportunities for pharmacotherapy of GCA and RPM (as well as other IMRDs) are associated with the use of biologic agents that block the activity of cytokines involved in the immunopathogenesis of diseases, and in recent years, JAK (Janus kinase) inhibitors. Among pharmacological “targets,” special attention is drawn to interleukin (IL) 6, a pleiotropic cytokine involved in the development of inflammation, immune response, immunometabolism, cancerogenesis, vascular wall remodeling, etc. Currently, several biologic agents have been developed that are specific to both IL-6 receptor and IL-6: humanized monoclonal antibodies (mAbs) to the IL-6 receptor (tocilizumab), and human mAbs to IL-6 receptor (sarilumab and levilimab (BIOCAD)), humanized mAbs to IL-6 olokizumab (R-PHARM), etc. The article summarizes data regarding the effectiveness and safety of tocilizumab in GCA and RPM, recommendations for the use of IL-6 inhibitors in these diseases and discusses the prospects for further research.
Current concept of osteoporosis diagnosis and treatment in children
Authors: Toroptsova Natalia V. , Nikishina Irina P. , Nasonov Evgeny L.
Published: September 2024

Osteoporosis (OP) is a disease characterized by a decrease in bone strength, leading to an increased risk of fractures. Bone fragility in children may be due to genetic disorders, chronic underlying conditions or taking medications that negatively affect bone metabolism. The article considers the modern classification of OP in children, approaches to its diagnosis, the role of dual-energy X-ray absorptiometry for diagnosis.

The main goal of OP prevention and treatment is to achieve a higher peak of bone mass, improve bone microarchitectonics, and, as in adults, reduce the risk of fractures, prevent skeletal deformities, improve mobility, independence and quality of life. Recommendations for lifestyle changes are presented, including adequate calcium intake and vitamin D, taking antiresorptive drugs, as well as prospective management of children with OP.
Comparison of foci of active inflammation and fatty degeneration according to MRI and CT data of syndesmophytes in patients with ankylosing spondylitis
Authors: Kurbanmagomedov Magomed K. , Sakharova Ksenia V. , Agafonova Ekaterina M. , Urumova Margarita M. , Krasnenko Svetlana O. , Dimitreva Anastasia E. , Dubinina Tatiana V. , Erdes Shandor F.
Published: September 2024

Introduction. Syndesmophyte, which is the hallmark of ankylosing spondylitis (AS), is a vertically oriented ossification located outside the fibrous ring of the intervertebral disc. In recent decades, the most widespread theory is that after inflammation in the area of attachment of the fibrous ring to the vertebral body, fatty degeneration occurs with reparative processes, as a result of which the growth of new bone – syndesmophyte – begins. It is believed that the likelihood of developing syndesmophyte is two to three times higher in the angles of those vertebrae in which active inflammation or fatty changes were detected on magnetic resonance tomography (MRI) in the previous 2 years, the latter having a stronger association with subsequent pathological bone formation. However, this relationship is ambiguous according to different studies.

The aim – comparison of the exact localization of magnetic resonance tomography and computed tomography (CT) signs of lesions on the vertebral endplates, characteristic of axial spondyloarthritis, in patients with ankylosing spondylitis.

Material and methods. The cross-sectional study included 10 patients with AS who met the inclusion criteria.

All patients underwent a standard examination for AS, as well as MRI and CT examination of the lumbar spine.

A special technique for joint assessment of changes detected during MRI and CT examination has been developed.

For the primary analysis, changes found on the upper endplates of 5 lumbar vertebrae were taken.

Results. On the upper endplates of 5 lumbar vertebrae, a CT examination revealed 35 syndesmophytes (from 1 to 7 syndesmophytes in 1 patient), and MRI revealed 9 foci of acute inflammation and 24 of chronic inflammation (fatty degeneration). When jointly analyzing the MRI foci of detectable inflammation and syndesmophytes transferred to the vertebral diagram, it turned out that in the majority of cases (68%), the latter were not associated with sites of active and/or chronic inflammation. Correlation analysis showed a certain direct relationship only between the number of syndesmophytes and foci of chronic inflammation (r=0.68).

Discussion. Preliminary data show that the proposed method for comparing MRI and CT lesions in AS allows us to jointly study the localization of MRI and CT spinal injuries in patients with AS using multidirectional sections. The first results of our one-time study showed that in most cases the localization of developing syndesmophytes does not coincide with the foci of inflammation detected by MRI (both acute and chronic).
Experience with olokizumab in the treatment of polymyalgia rheumatica and giant cell arteritis: A series of cases
Authors: Meshkov Alexey D. , Maslyansky Alexey L. , Bulanov Nikolay M. , Filatova Ekaterina E. , Novikov Pavel I. , Naumov Anton V. , Tkacheva Olga N.
Published: September 2024

Glucocorticoids are the basis for the treatment of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR), however, their long-term use is associated with a number of well-known side effects. Despite the fact that a significant number of patients with these diseases require long-term treatment, approaches to long-term therapy remain insufficiently developed. The role of traditional anti-inflammatory drugs remains uncertain due to insufficient efficacy and inconclusive evidence base. A possible solution of this problem is the use of biological agents, in particular, affecting the interleukin (IL-6) axis. This series of clinical observations presents the experience of using the IL-6 inhibitor olokizumab in the treatment of GCA and PMR. The data obtained are consistent with the positive international experience of using drugs of this group and demonstrate both efficiency of disease activity control and a pronounced steroid-sparring effect. Olokizumab is a promising drug for the treatment of GCA and PMR.
Integrating AI with Salesforce for Predictive Customer Insights
Authors:   USA, Guduru Venkat Sumanth
Published: September 2024

This paper discusses the benefits, architecture, and real-world applications of integration between Salesforce and Artificial Intelligence in generating predictive customer insights. AI boosts CRM through insights, functioning process automation, and the ability to perform predictive analytics. The essay has explored the architectural requirements to make integration seamless, put a condition for a case example of a retail company using an AI-driven churn prediction system, and shows some challenges that might be encountered: with data quality, model selection, scalability, and some ethical concerns. Tackling these problems will enable businesses to apply AI as a tool to get better at decision-making and improve customer satisfaction.
Enhancing Customer Experience with Personalized Data Strategies in Salesforce Data Cloud
Authors:   USA, Guduru Venkat Sumanth
Published: September 2024

Today’s companies rely on data to deal with customers and hence, personalization has become a major strategy for winning over customers. This paper aims to investigate improvement of customer experience with personalized data strategies in Salesforce data cloud. It focuses on analyzing the architecture of Salesforce Data Cloud, real-time analytics, activation features as well as its unification of data. The framework provides a clear view on how the organization should collect data, create a single customer view and progress to intelligent segmentation. The paper also aims at the management of customer interactions across the multichannel environment, using predictive insight and the sentiment of analysis to guide a real-time engagement. The dark side of hyper personalization including ethical implications and data privacy concerns is discussed in detail, as a call for responsible use of methods in data collection. Salesforce Data Cloud helps organizations to build and maintain meaningful customer relationships that create value and bring about increased and sustained organizational an organizational growth.
Nuevo registro de Myrmecophaga tridactyla (Pilosa: Myrmecophagidae) para La Guajira: ampliando el conocimiento sobre su distribución en Colombia
Authors: Cáceres-Martínez Carlos Herney , Aya-Cuero Carlos A. , Zamora-Abrego Joan Gastón , Acevedo-Quintero Juan Fernando
Published: September 2024

El oso hormiguero gigante, Myrmecophaga tridactyla (Mammalia: Pilosa: Myrmecophagidae), es el único miembro vivo del género y se encuentra restringido a Centroamérica y Suramérica. Actualmente se encuentra catalogado como una especie Vulnerable (VU); sin embargo, en varios países ya ha sido declarado como una especie extinta. Para Colombia su patrón de distribución es fragmentado y cada vez más reducido a lo largo del país. Debido a su importancia y estado de vulnerabilidad es importante generar información confiable sobre sus poblaciones, así como de sus patrones cambiantes de distribución. En este trabajo se reporta a partir de muestreo con fototrampeo, la presencia de M. tridactyla para el departamento de La Guajira, siendo el registro reciente más septentrional de la especie para Colombia. Adicionalmente, se presenta una actualización sobre la distribución de la especie a nivel nacional, y se resalta la necesidad de implementar acciones de monitoreo y conservación de esta especie en el Caribe colombiano.
Student Mistakes In Solving SPLDV Story Problems: An Analysis Based On Newman's Procedure
Authors: Jeklin Nadia Legi  , Jorry F. Monoarfa  , Vivian E. Regar
Published: September 2024

This study seeks to characterize the categories of errors students make when solving SPLDV word problems using Newman's method. Descriptive qualitative research methods are employed. This study was conducted in class VIII A at SMP Negeri 4 Touluaan during the even semester of the academic year 2021-2022. The research participants were fifteen students. Then, a test comprised of SPLDV story questions was administered to collect data. The test results were then used to select 5 students at random for interviews, based on their distinct errors. The obtained data was analyzed using the following steps: data reduction, data presentation, and conclusion. Most of the class VIIIA students at SMP N 4 Touluaan made reading errors (4.44%), understanding errors (13.33%), transformation errors (26.66%), process skills errors (48.88%), and mnemonic skills errors (68.88%).
Manajemen Komunikasi Orang Tua dalam Meningkatkan Prestasi Anak Usia Dini (AUD)
Authors: Marisa Aulia Gea  , Difly Praise Malelak
Published: September 2024

Early childhood achievement can be said to have declined, this is due to the lack of communication management of parents towards children. Achievement is something that needs to be developed, especially in the age range of 0-6 years (early childhood). Based on research conducted by the author, the main way that parents can develop or improve children's achievement is through parental communication management. The application of communication management can be done without cornering the interlocutor.
Global sustainable development programs: Challenges to the achievement of the goals
Authors: Vasiliev V. P.
Published: September 2024

In this interview the Head of the Chair of Sociology of Public Administration of the School of Sociology, Lomonosov Moscow State University, Vladimir P. Vasiliev, shares his assessments of the results and significance of the UN climate Conference held in November-December 2023 in the UAE (Dubai). He examines the current dynamics of the implementation of the Paris Climate Agreement, the key provisions of the reports of the World Health Organization and the International Energy Agency, and focuses on the discussions that unfolded at the conference on the use of fossil fuels and the transition to renewable energy sources. It is noted that the process of implementing the Sustainable Development Goals (SDGs) is currently facing a number of serious obstacles, both economic and socio-political in nature. Meanwhile, failure to implement the SDGs is fraught with a sharp aggravation of the problems of global inequality, food security and climate migration, especially dangerous for the most vulnerable groups of the population. It is noted that under these conditions, the Russian Federation is pursuing a long-term climate policy aimed at achieving a balance between anthropogenic greenhouse gas emissions and their absorption, in a way that is consistent with national interests and priorities of socio-economic development. Hopefully, scientists from Lomonosov Moscow State University will be able to contribute both to improving the environmental policy of the Russian Federation and to defining the global climate agenda. And for this, in turn, it is important to develop and strengthen the dialogue between the leading scientific schools of Moscow State University.
Claves para el tratamiento del consumo de drogas en jóvenes delincuentes: un análisis en población española
Authors: Fernández Moreno Álvaro , Redondo Rodríguez Natalia , Graña Gómez José Luis
Published: September 2024

El objetivo del presente estudio es identificar las variables implicadas en el éxito terapéutico en el tratamiento de los problemas asociados al consumo de drogas en menores infractores. Se realizó un estudio longitudinal con 79 adolescentes internos en un Centro de Ejecución de Medidas Judiciales español con problemas graves derivados del consumo de drogas y que realizaron una intervención terapéutica para paliarlos. Para el análisis de los datos se realizó una regresión logística binaria. El porcentaje de éxito terapéutico tras 3 meses de la finalización del internamiento fue del 53,2%. El modelo de regresión clasificó correctamente el 86,1% de los casos, pronosticando de manera adecuada el 85,7% del éxito y el 86,5% del fracaso terapéutico, identificándose cuatro variables predictoras: número de expedientes judiciales que justifican el ingreso, número de sanciones leves durante el internamiento, consumo problemático previo de éxtasis y riesgo en personalidad y conducta. Los resultados sugieren que es preciso orientar tanto las medidas judiciales como las intervenciones terapéuticas en función de la cronificación de la conducta delictiva y diversos factores de personalidad.
Evaluation of patients with positive anti-mitochondiral antibody and normal alkaline phosphatase levels for primary biliary cholangitis
Authors: Ellez H.I. , Danis N , Akarca U.S.
Published: September 2024

Primary Biliary Cholangitis (PBC) is a chronic cholestatic liver disease typically diagnosed by elevated cholestatic liver enzymes and a positive anti-mitochondrial antibody (AMA) test. The clinical importance of AMA positivity in patients with normal cholestatic liver enzymes is unclear. The aim of this study was to determine the relationship between PBC and AMA positivity detected in individuals with normal cholestatic enzyme levels. The files of patients with AMA and/or AMA-M2 positivity between 2009 and 2018 and whose alkaline phosphatase (ALP) levels were below upper limit of normal (ULN) at initial admission were retrospectively analyzed. The ALP levels were normal in all patients. All patients had AMA positivity demonstrated by indirect immunofluorescence (IIF) or AMA-M2 positivity demonstrated by ELISA. A total of 16 patients underwent liver biopsy and seven (43.75%) showed changes consistent with those with PBC. A total of 12 patients were diagnosed with PBC and were treated and followed up with this diagnosis. People with AMA positivity and normal cholestasis enzyme levels are closely associated with PBC. Some of these patients were diagnosed with PBC as a result of biopsy and some were diagnosed by clinical and laboratory findings during follow-up.. The patients with an AMA titration of 1/20 were not associated with PBC. In our study, results similar to the studies confirmed by biopsies were obtained. In this regard, there is a need for prospective and retrospective studies with longer follow-up periods.
PARADIGMAS ATUAIS, VENTOS INOVADORES: EXPLORANDO NOVAS ABORDAGENS NA FORMAÇÃO DOCENTE POR MEIO DOS PROGRAMAS INSTITUCIONAIS PIBID E PRP, COM ENFOQUE NA INCLUSÃO DE QUESTÕES DE GÊNERO E SEXUALIDADE
Authors: Costa Cleber Nonato Macedo , Silva Wanessa Christina Coelho da , Carmo Valmir Castro do , Vale Valdicley Vieira
Published: September 2024

O artigo destaca a importância crucial dos programas Pibid e PRP na transformação da formação docente. Esses programas proporcionam uma fusão prática entre teoria e prática, fortalecendo não apenas o conhecimento acadêmico, mas também a construção de uma identidade docente sólida e comprometida. Além disso, o texto aborda a implementação de ações afirmativas nos programas, destacando-as como estratégias eficazes para mitigar desigualdades historicamente enraizadas no sistema educacional. O enfoque na inclusão de questões de gênero e sexualidade amplia a compreensão da diversidade, promovendo um ambiente educacional mais enriquecedor e inclusivo. Na metodologia, a abordagem mista, que combina elementos qualitativos e quantitativos, assegura uma compreensão holística das práticas educacionais. Os resultados indicam impactos positivos das ações afirmativas, mas também apontam desafios persistentes na implementação efetiva, ressaltando a necessidade contínua de sensibilização e capacitação. O papel fundamental do professor na promoção da inclusão destaca a importância de abordagens personalizadas e flexíveis, incentivando estratégias inovadoras para criar ambientes educacionais verdadeiramente inclusivos. No âmbito das contribuições para a formação docente, o artigo destaca a importância da sensibilização contínua, capacitação e adoção de práticas inclusivas. Sugere também futuras pesquisas centradas na superação de resistências e lacunas na implementação de ações afirmativas, bem como na avaliação a longo prazo do impacto dessas iniciativas na formação docente e na promoção da inclusão educacional.
SORAS, A ground-based 110 GHz microwave radiometer for measuring the stratospheric ozone vertical profile in Seoul
Authors: Ka Soohyun , Oh Jung Jin
Published: September 2024

Abstract. A ground-based 110 GHz radiometer was designed to measure the stratospheric ozone vertical profile by observing the 110.836 GHz ozone emission spectrum and the instrument has been operational at Sookmyung Women’s University (37.54° N, 126.97° E) in Seoul, Korea. In this paper, we detail the instrumental design, calibration procedures, correction methods, and the retrieved ozone vertical profile. The instrument is a heterodyne total power radiometer. It down-converts the observed 110.836 GHz ozone frequency to 0.609 GHz, with a frequency resolution of 61 kHz and a bandwidth of 800 MHz. The spectral intensity is digitized using a fast Fourier transform spectrometer. For hot-cold calibration, we use microwave absorbers at room temperature and liquid nitrogen as calibration targets. Tropospheric opacity is corrected using the continuous tipping curve calibration. The measured opacities were compared with simulated values from the Korea Local Analysis and Prediction System (KLAPS) data. Additionally, since 2016, the stratospheric ozone profiles over Seoul have been demonstrated for the vertical range of 100 hPa – 0.3 hPa (16 km–70 km) with validation performed by comparing them to the ozone profiles from the MLS on AURA satellite.
T&C-CROP: Representing mechanistic crop growth with a terrestrial biosphere model (T&C, v1.5): Model formulation and validation
Authors: Buckley Paules Jordi , Fatichi Simone , Warring Bonnie , Paschalis Athanasios
Published: September 2024

Abstract. Cropland cultivation is fundamental to food security and plays a crucial role in the global water, energy, and carbon cycles. However, our understanding of how climate change will impact cropland functions is still limited. This knowledge gap is partly due to the simplifications made in Terrestrial Biosphere Models (TBMs), which often overlook essential agricultural management practices such as irrigation and fertilizer application, and simplify critical physiological crop processes. Here we demonstrate how with minor, parsimonious enhancements to the TBM T&C it is possible to accurately represent a complex cropland system. Our modified model, T&C-CROP, incorporates realistic agricultural management practices, including complex crop rotations, irrigation and fertilization regimes, along with their effects on soil biogeochemical cycling. We successfully validate T&C-CROP across four distinct agricultural sites, encompassing diverse cropping systems such as multi-crop rotations, monoculture, and managed grassland. A comprehensive validation of T&C-CROP was conducted, encompassing water, energy, and carbon fluxes, Leaf Area Index (LAI), and organ-specific yields. Our model effectively captured the heterogeneity in daily land surface energy balances across crop sites, achieving coefficients of determination of 0.77, 0.48, and 0.87 for observed versus simulated net radiation (Rn), sensible heat flux (H), and latent heat flux (LE), respectively. Seasonal, crop-specific gross primary production (GPP) was simulated with an average absolute bias of less than 10 %. Peak season LAI was accurately represented, with an r2 of 0.67. Harvested yields (above-ground biomass, grain, and straw) were generally simulated within 10–20 % accuracy of observed values, although inter-annual variations in crop-specific growth were difficult to capture.
Simultaneous measurement of greenhouse gases (CH4, CO2 and N2O) at atmospheric levels using a gas chromatography system
Authors: Bucha Michal , Lewicka-Szczebak Dominika , Wójtowicz Piotr
Published: September 2024

Abstract. This article presents a simple method for determining greenhouse gases (CH4, CO2, N2O) at ambient atmospheric levels using a chromatographic system. The novelty of the presented method is the application of a Carboxen 1010 PLOT capillary column for separation of trace gases – CH4, CO2 and N2O – from air samples and their detection using a barrier discharge ionisation detector (BID). Simultaneously, a parallel molecular sieve column connected to a thermal conductivity detector (TCD) allowed the determination of CH4, N2 and O2 concentrations from 0.1 to 100 %. The system was equipped with an autosampler transferring the samples without air contamination thanks to a vacuum pump-inert gas flushing option. Method validation was performed using commercial gas standards and undertaking a comparison measurement with a reference method: optical methods applying Picarro isotope and concentration instruments with cavity ring-down spectroscopy for CO2, CH4 and N2O. A three-day continuous measurement series of the lowest GHG concentrations in ambient air and tests of typical vial sample measurements with increased GHG concentrations were performed. The advantage of this method is that the system is easy to set up and allows for simultaneous detection and analysis of the main GHGs in their ambient concentrations using one GC column and one detector, thereby omitting the need for an electron capture detector (ECD) containing radiogenic components for N2O analysis and a flame ionisation detector (FID) with a methaniser for low-concentration CO2 samples. The simplification of the system reduces analytical costs, facilitates instrument maintenance and improves measurement robustness.