bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Total Hip Arthroplasty Outcomes after Failed Femoral Wedge or Curved Varus Osteotomy
Authors: Sonohata Motoki , Kitajima Masaru , Kawano Shunsuke , Mawatari Masaaki
Published: June 2018

Background:

Differences in clinical and radiographic results following total hip arthroplasty between failed wedge and curved varus osteotomy are unclear.

Objective:

To investigate differences in clinical and radiographic results following total hip arthroplasty in patients who exhibited failed wedge or curved varus osteotomy.

Method:

We performed 18 total hip arthroplasties after failed femoral varus osteotomy. Hips were divided into two groups: 14 had failed wedge varus osteotomy and four had failed curved varus osteotomy. Average ages at osteotomy and total hip arthroplasty were 27 years old (range, 10-46 years old) and 56 years old (range, 25-74 years old), respectively. The average duration of follow-up monitoring was 72.2 months (range, 54-91 months). Clinical and radiographic evaluations were completed for each group.

Results:

The Japanese Orthopaedic Association hip score of total hip arthroplasty after failed varus osteotomy significantly improved at the last follow-up in both groups. However, hip score at the last follow-up was significantly higher after failed curved varus osteotomy than after failed wedge varus osteotomy (p<0.01). Four hips that failed wedge varus osteotomy underwent subtrochanteric corrective osteotomy with total hip arthroplasty. Radiographic evaluation showed that three stems for total hip arthroplasty after failed wedge varus osteotomy were inserted in malposition, and all stems in total hip arthroplasty after failed curved varus osteotomy were inserted in the normal position.

Conclusion:

Surgeons performing femoral varus osteotomy should consider possible future conversion to total hip arthroplasty. Curved varus osteotomy is more suitable than wedge varus osteotomy for future conversion to total hip arthroplasty.
Evaluation of the Percolation Sensitivity of Loose Sandstone Using Digital Core Technology
Authors: Pang Jin , Li Junnan , Liang Jie , Wang XiaoLu , Kui Mingqing
Published: June 2018

Background:

The integrity of the extracted core in loose sandstone gas reservoirs is poor, and because hydration and collapse easily occur, it is difficult to evaluate the sensitivity characteristics accurately by the traditional core flooding experiments.

Objectives:

We instead investigate the stress sensitivity and water sensitivity of the formation water soaking time using digital core technology.

Methods:

We take the core of a loose sandstone gas reservoir as a research object and begin by scanning the core samples with a CT scanner. A three-dimensional image of the core can be obtained, the digital information extracted, the pore structure of the porous media mapped directly to the network, and a digital core established using the principles of fractal geometry. The three-dimensional pore network model can also be extracted. Next, we can compare and correct the results calculated by the model based on the real core experimental results, and an objective and effective digital core model can be obtained.

Results and Conclusion:

Finally, we can calculate the different effective stress, pore throat parameters (pore throat radius, shape factor, coordination number, pore-throat ratio) and relative permeability of different formation water injury times. The research results demonstrate that in sandstone gas reservoir development, as the effective stress continuously increases, the rock pore-throat parameters continue to decrease, and the permeability of the reservoir rock ultimately declines by more than 43.2%. Clay minerals will expand after the edge and bottom water intrude into the reservoir and soak it for a long time: the pore throat is significantly narrowed within 30 days, while after 30 days more, the pore throat undergoes any only slight further changes, and the final permeability decline of the reservoir rock is up to 5.7%. The research results provide important basic petrophysical data for the development of loose sandstone gas reservoirs which, in turn, provide a scientific basis for formulating a reasonable gas production rate in a gas reservoir.
Some Heathenish and Superstitious Rites: A Letter from Lewis, 1700
Authors: Stiùbhart Dòmhnall Uilleam
Published: June 2018

No abstract
Brìgh ’Chiùil: Vernacular Ear-Learned Piping in Cape Breton and South Uist Explored through Seanchas-Based Narratives
Authors: Falzett Tiber
Published: June 2018

No abstract
‘Hildina’ - A Norn Ballad in Shetland
Authors: Fischer Frances J.
Published: June 2018

No abstract
Piping Sung: Women, Canntaireachd and the Role of the Tradition-Bearer
Authors: Dickson Joshua
Published: June 2018

Canntaireachd (pronounced ‘counter-achk’), Gaelic for ‘chanting’, is a complex oral notation used by Scottish pipers for centuries to teach repertoire and performance style in the courtly, ceremonial ceòl mór idiom. Its popular historiography since the 19th century suggests it was fixed and highly formulaic in structure and therefore formal (as befitting its connection to ceòl mór), its use the preserve of the studied elite. However, field recordings of pipers and other tradition-bearers collected and archived since the 1950s in the School of Scottish Studies present a vast trove of evidence suggesting that canntaireachd as a living, vocal medium was (and remains) a dynamic and flexible tool, adapted and refined to personal tastes by each musician; and that it was (is) widely used as well in the transmission of the vernacular ceòl beag idiom - pipe music for dancing and marching. In this paper, I offer some remarks on the nature of canntaireachd, followed by a review of the role of women in the transmission and performance of Highland, and specifically Hebridean, bagpipe music, including the use of canntaireachd as a surrogate performance practice. There follows a case study of Mary Morrison, a woman of twentieth century Barra upbringing, who specialised in performing canntaireachd; concluding with a discussion on what her singing of pipe music has to say about her knowledge of piping and the nature of her role as, arguably, a piping tradition-bearer.
Las decisiones extranjeras de divorcio frente a la exigencia de conformidad con el derecho del foro: el ejemplo chileno y peruano
Authors: Moreno Cordero Gisela
Published: June 2018

Las instituciones de familia se encuentran especialmente expuestas al impacto negativo del orden público en su vertiente sustantiva. En los procesos de reconocimiento de decisiones extranjeras de divorcio esta excepcional cláusula suele identificarte con situaciones en las que no se han visto afectados principios y valores esenciales del foro. Esto es precisamente lo que sucede en Chile y en Perú, sedes en las que el éxito de las decisiones extranjeras de divorcio se hace depender de una identificación entre la causal aplicada al divorcio decretado en el extranjero y las causales previstas en sus respectivos derechos internos. Para evitar las nocivas consecuencias que este comportamiento genera para el tráfico externo de estas decisiones y llegar a conclusiones certeras sobre su origen, el presente estudio será abordado a partir de la información que aportan las distintas fuentes que vinculan a dichos Estados en este ámbito material, el tratamiento dado por la doctrina y su proyección en la jurisprudencia local.
Usos e costumes: seria possível voltarmos ao velho coração do direito comercial?
Authors: Pereira de Araújo Alan
Published: June 2018

O presente artigo visa examinar, em linhas gerais, a disciplina jurídica dos usos e costumes no direito privado, especialmente no direito comercial/empresarial, partindo de sua análise no ordenamento pátrio, sem prejuízo de alguma contribuição oferecida pelo ordenamento estrangeiro. Investiga-se a possível compatibilidade ou aptidão dos usos e costumes para estimular o desenvolvimento do comércio nos dias atuais.
El sistema de enseñanza del derecho y acceso a las profesiones jurídicas en Alemania: lecciones para el debate en México
Authors: Pérez Hurtado Luis Fernando
Published: June 2018

El sistema de justicia en Alemania es de los más sólidos en el mundo. Dos de las principales razones son su proceso de formación de los futuros profesionales del derecho y los mecanismos de acceso a las profesiones jurídicas. Este artículo analiza distintos aspectos de la enseñanza del derecho y del acceso a las profesiones jurídicas en Alemania. Surge a partir de una estancia de investigación que el autor realizó en Alemania en 2016 con el apoyo de la Fundación Konrad Adenauer, donde visitó escuelas de derecho, asociaciones de abogados y oficinas de gobierno y entrevistó profesores, estudiantes, funcionarios públicos, legisladores, jueces, abogados y otros actores relevantes en estos temas. El objetivo final es aportar elementos y experiencias de otros países para enriquecer el debate actual en México para mejorar la calidad de la educación jurídica y el ejercicio profesional del derecho.
Bullying: Case Studies on Comprehensive Reparation of Damage
Authors: Cantoral Domínguez Karla , Pérez Fuentes Gisela María
Published: June 2018

Bullying is a type of behavior that has been studied more from psychological and sociological perspectives, but little has been done about the legal consequences that generate this type of illegal act. In Mexico, there are special laws in some states, but there is no genuine public policy that provides a mechanism of redress for the victim. Therefore, this investigation conducted a study of comparative law on the treatment given to bullying in the United States. This article also presents a study of the legal system that punishes the administrative form of bullying in Mexico, highlighting the most advanced states such as Coahuila, Jalisco, Nuevo León, Oaxaca, Quintana Roo, Veracruz, Yucatán and Zacatecas. This article also makes an assessment of bullying and its treatment to identify gaps in legislation and the failure of public policies to protect the best interests of the children. In these cases, the Federal Supreme Court of Justice (SCJN) rulings on these cases are analyzed and compared to the damage suffered by those affected and the need for comprehensive reparation.
Simulación y subterfugio laboral: a propósito del alcance del actual artículo 507 del Código del Trabajo chileno
Authors: Ruay Sáez Francisco Alberto
Published: June 2018

En la presente exposición se pretende explorar cuáles son los alcances de las figuras de “simulación” y “subterfugio laboral”, contenidos y tipificados en el artículo 507 del Código del Trabajo actualmente vigente en Chile, introducidos a través de la reforma legal denominada “Ley Multirut”. Se realiza una exposición sobre las discusiones doctrinarias desarrolladas a propósito del antiguo artículo 478 del Código del Trabajo chileno, su relación con instituciones conexas como lo son el fraude a la ley o el levantamiento del velo corporativo, para luego afrontar críticamente la lectura del actual texto legal vigente en el artículo 507 y su vinculación con la declaración de único empleador.
Self-Assessment and Strategic Planning in the Retail Co-op Food Sector: Using the Sustainability and Planning Scorecard Kit (SPSK) in a Crisis Context
Authors: Brown Leslie , Hicks Elizabeth , Leclerc André , Petersen Bonnie
Published: June 2018

After the 2015 collapse of Co-op Atlantic, the second-tier co-operative providing services and support to retail co-operatives in Canada’s Atlantic Provinces, many co-operatives contracted with Sobeys to provide services under the Foodland banner. The co-operatives’ ongoing challenge is to reaffirm their place in the community and their co-operative identity, contributing to ongoing innovation around a co-operative model appropriate to these new circumstances. This article analyzes the strategic planning process undertaken by a small PEI Foodland co-operative as it defined new directions during this crisis. It also examines the co-operative’s use of a collaboratively developed Sustainability and Planning Scorecard Toolkit. The toolkit was designed to help co-operatives through their self-evaluation process, while also facilitating the further steps of planning and taking action.RÉSUMÉSuite au démantèlement de Coop Atlantique en 2015, la coopérative de second niveau qui offrait des services et du soutien aux coopératives de consommation dans les provinces atlantiques, plusieurs coopératives ont négocié une entente d’approvisionnement avec Sobeys, sous la bannière Foodland. Ces coopératives doivent réaffirmer leur place dans la communauté et leur distinction coopérative, et contribuer au développement d’un modèle coopératif innovant et adapté à cette nouvelle réalité. Cette recherche analyse le processus de planification stratégique ayant permis à une petite coopérative de l’Î.-P.-É. de relever ce défi dans un contexte de crise. Nous étudions aussi l’utilisation par la coopérative de l’Outil d’évaluation et de planification du développement coopératif durable, outil développé de façon collaborative. Cet outil a été conçu pour appuyer les coopératives dans une démarche d’auto-évaluation, tout en leur permettant de poursuivre les différentes étapes de conception et de mise en oeuvre d’un plan stratégique.
ELAZIĞ KENTİ İÇİN ARKEOPARK ÖNERİSİ
Authors: ASLAN Fürüzan , ATEŞ Oğuz
Published: June 2018

Öz: Amaç: Bu çalışmada arkeolojik sit alanlarının odak noktası

haline getirilebilmesi için peyzaj tasarımı aracılığıyla tanıtımının yapılması,

arkeolojik alanlarda peyzaj kavramının oluşturulması amaçlanmıştır. Yöntem: Yöntem aşaması; verilerin

toplanması, analiz, verilerin çözüm ve yorumlanması başlıkları altında

incelenmiştir. Veri toplama aşamasında; çalışma alanında yapılan gözlemler,

yetkililerle yapılan görüşmeler, çalışma alanı fotoğraf çekimleri ve kurum

kuruluşlardan elde edilen veriler elde edilmiştir. Analiz aşamasında; Veri

analizleri ve gztf analizleri yapılmıştır. Verilerin çözümü ve yorumlanması

aşamasında ise;  Elazığ Şahinkaya Köyü

Arkeopark alanına dair yapılan analiz, oluşturulan veriler ve anketler neticesinde

yorumlanıp öneriler getirilmiştir. Bulgular:

Elazığ’da bugün İslam ve Hıristiyan dinlerine mensup, Türk, Kürt ve Ermeni gibi

etnik kökene sahip yurttaşlar bir arada yaşamaktadır. Çalışmada yapılan 25

soruluk anket verileri doğrultusunda, Elazığ’da ki halkın kültürel ve tarihi

mirasını korumak istediği fakat çocuklarını müzelere ve tarihi mekânlara

götürme durumunun çok düşük olduğu saptanmıştır. Sonuç:  Kültür turizmi

açısından arkeolojik sit alanlarının önemi günden güne artmakta ve bu

doğrultuda peyzaj mimarlığı meslek disiplini tarafından oluşturulacak peyzaj

planlama ve tasarımlarına ihtiyaç duyulmaktadır. Bu çerçevede; Elazığ ili

Şahinkaya köyüne bir arkeopark tasarımı önerisi getirilmiştir.
Barricadas, traficantes e favelas: uma análise sobre as representações e percepções sobre a categoria “risco” dentro dos espaços urbanos no Jardim Catarina
Authors: Ribeiro Fernanda De Souza , Platero Klarissa Almeida Silva
Published: June 2018

Este artigo busca compreender as diferentes percepções sobre a categoria “risco” entre os moradores do bairro Jardim Catarina, que possui diversas localidades consideradas “áreas de risco”. Para uma melhor compreensão desta categoria e quais fatores podem ser considerados como importantes para a construção dela, as entrevistas com moradores, observações de campo e construção de mapas (croquis) foram os métodos utilizados para conseguir chegar aos principais fatores que contribuem para a demarcação destas áreas de risco. A análise socioeconômica e territorial do lugar e a complexa relação entre os moradores e o tráfico de drogas e sua atuação foram elementos importantes para nortear a pesquisa para conseguir chegar o mais próximo possível de se compreender quais os processos sociais que levam à construção da categoria “risco” no contexto do Jardim Catarina.
A CONSTRUÇÃO E O CONTROLE IDEOLÓGICO DO “CRIMINOSO” NO BRASIL PÓS-ESCRAVIDÃO
Authors: Rodrigues Igor De Souza , Delgado Letícia Paiva
Published: June 2018

O presente trabalho é fruto de quase uma década de pesquisa sobre as assimetrias entre variáveis sociais, tal como raça, inclusive em termos de poder, a identidade e o controle social. Busca investigar a construção do rótulo “criminoso” no Brasil Pós-escravidão – cuja transformação na economia das punições é o princípio fundador deste controle simbólico. Discute-se a escolha, influência e readaptação do evolucionismo lombrosiano no debate racialista nacional, “a originalidade da cópia”, centrado especialmente nas figuras de Silvio Romero e Nina Rodrigues. O respectivo debate, que se colocava entre o fim do Século XIX e o começo do Século XX, é o expressivo aguilhão de como a criminologia se confundia e, mais do que isso, se encarregava da justificação e remanejamento ideológico do controle social sem o açoite.
A narrativa das reformas estruturais no Brasil
Authors: Antunes Ludmila Rodrigues , Vianna Maria Lúcia Teixeira Werneck
Published: June 2018

Esse texto pretende abordar a relação entre modernização do aparato estatal, particularmente no que tange às suas interações com a sociedade, e a construção dos sistemas de seguridade social que nucleiam os Estados de bem-estar contemporâneos. O objetivo específico, porém, é tratar essa questão sob o prisma da crítica a uma ótica que passou a dominar assustadoramente as análises no campo da política e a reflexão, em geral, no campo das ciências sociais. Uma ótica que se expressa no idioma da narrativa, da pós-verdade, da política posfáctica, como mencionado por Wolgang Streeck. O discurso oficial em torno das reformas ditas estruturais e indispensáveis no Brasil, hoje, é puro culto à TINA(There Is No Alternative). E totalmente formulado na linguagem tipo “palavra do ano”, a retórica da narrativa, um termo que migrou da teoria literária para a política, onde encontrou calorosa acolhida, justamente por exprimir uma história com significado, uma história para a qual se transferem emoções, que proporciona uma orientação e que transmite confiança.Palavras-chave: reformas da previdência, seguridade social, retórica da narrativa
A judicialização e seus intérpretes: uma análise comparativa de referenciais teóricos
Authors: Da Silva Rodrigues Paulo Joaquim
Published: June 2018

A judicialização da política tornou-se um conceito incontornável para as pesquisas que investigam as relações entre instituições judiciárias e Política no Brasil. A despeito de sua ampla utilização, a judicialização não apresenta definição e sentido unívoco. Este artigo dedica-se a uma análise comparativa entre os principais referenciais teóricos do conceito de judicialização da política. Com o auxílio da metodologia da história dos conceitos, busca-se sistematizar as principais definições e sentidos da judicialização presentes nas pesquisas realizadas no Brasil. Assevera-se a baixa capacidade analítica do conceito, destaca-se o influxo que o mesmo sofre do contexto no qual é utilizado, e, ressaltam-se os prognósticos contidos nas definições teóricas.
O processo histórico de evolução do direito na Sociologia de Niklas Luhmann
Authors: Luz Vladimir De Carvalho
Published: June 2018

O presente artigo analisa os elementos centrais da proposta teórica de Niklas Luhmann sobre o processo histórico de diferenciação estrutural do direito moderno no ocidente. Nesse sentido, num primeiro momento, realiza-se um breve inventário das influências da Sociologia funcionalista e seus desdobramentos no pensamento de Luhmann. Em um segundo momento, basicamente a partir de sua obra o Direito da Sociedade, tem-se como ponto de chegada do presente artigo a análise da ideia de evolução como categoria central para a Teoria dos Sistemas de Luhmann, a partir da qual, para este autor, a diferenciação estrutural do direito positivo poderia ser melhor entendida em seu processo histórico de variação.
Fabricando vocação, mérito e moralidade: candidatos à juiz na França e seus dossiês
Authors: Fontainha Fernando De Castro
Published: June 2018

O objetivo desta pesquisa é trazer uma reflexão ao discurso presente sobre o ofício da magistratura, tendo por base as referências cognitivas em jogo no momento da reprodução do corpo profissional por concurso público. Este trabalho visa abordar uma etapa preparatória do concurso nacional da magistratura francesa como um processo interativo: a formação de ferramentas cognitivas antes da realização do concurso. Ou, ainda: como os candidatos ao concurso “fabricam” seus dossiês de candidatura. Para tanto, utilizamos uma análise qualitativa documental realizada em 750 dossiês de candidatura ao concurso 2007, examinados durante estágio de pesquisas na Escola nacional da Magistratura Francesa em maio e junho de 2008. Do ponto de vista teórico, utilizamos o interacionismo estratégico de Goffman e a etnometodologia de Garfinkel para tentar compor o sentido da construção contextual de categorias centrais como mérito, moralidade, vocação e motivação dos candidatos ao concurso.
JURISTAS DO COMISSIONISMO: USOS E MOBILIZAÇÕES DO DIREITO NA COMISSÃO DA VERDADE DA UNB
Authors: Lima Amanda Evelyn
Published: June 2018

A Comissão Anísio Teixeira de Memória e Verdade (CATMV) da Universidade de Brasília foi a primeira comissão da verdade instalada em uma universidade em todo o mundo. A CATMV foi responsável por investigar as graves violações de Direitos Humanos ocorridas na UnB durante o período autoritário de 1964 a 1988. Este trabalho é parte de uma pesquisa de fôlego sobre o fenômeno do comissionismo no Brasil, que coletou informações das mais de cem comissões da verdade instaladas no país. Seu objetivo é evidenciar a presença, o uso e mobilizações do Direito na comissão da verdade da UnB através das narrativas apresentadas por seus comissionados e demonstrar que o fenômeno do comissionismo pode também ser interpretado como uma etapa de um processo de expansão de mercado para os profissionais dos direitos humanos.
Uma ambiguidade com pretensões duradouras: a formulação liberal da representação profissional e sua distinção em face do corporativismo
Authors: Velloso Paula Campos Pimenta
Published: June 2018

No presente artigo, opera-se a distinção entre as concepções de representação das associações profissionais e de corporativismo. Para fazê-lo, recupera-se o contexto das primeiras décadas do século XX, quando o liberalismo precisou mudar de significado. Enquanto o século XIX experimentou a organização das nações segundo as premissas da filosofia liberal, as primeiras décadas do século XX testemunharam seu fracasso prático, tanto político quanto econômico. Dentre os conteúdos do liberalismo que sofreram alterações, a ideia de representação foi uma das que mais radicalmente se transformou. Não foi outra a razão que, no Brasil, a Constituição de 1934 fixou o convívio entre duas formas de representação na Câmara dos Deputados: a tradicional, dos representantes eleitos pelo povo, e a profissional, dos eleitos pelas “organizações profissionais”. O tema foi objeto de acalorado debate desde 1932, principalmente, sobre a potencialidade antiliberal desse tipo de representação num ambiente em que floresciam formas fascistas de corporativismo. Através da recuperação do debate sobre liberalismo no contexto constituinte que precede a promulgação da referida Constituição, pretende-se contribuir identificar as diferenças entre representação das associações profissionais e corporativismo.
Direitos dos civis e direito dos militares: Sensibilidades em conflito na administração pública do Estado do Rio de Janeiro
Authors: Arêas Jorge Alexandre Mancuso , Geraldo Pedro Heitor Barros
Published: June 2018

No presente artigo, analisamos as diferentes sensibilidades jurídicas em conflito nas formas de aplicação das normas no Sistema Jurídico do Estado do Rio de Janeiro. Demonstramos como são administrados os conflitos entre as tais sensibilidades no âmbito da administração civil e militar. Apontamos entendimentos como imposições particularizadas pelo órgão central do sistema jurídico do Estado, a Procuradoria Geral do Estado, no interior da estrutura da hierarquia burocrática. Constrastamos a concepção weberiana de burocracia com o direito, o qual funciona como uma instância social de legitimação da imposição da vontade dos membros da PGE apenas quando não é ausente a subordinação hierárquica, casos em que prevalece o saber local da administração militar.
Inércia inflacionária: uma análise de raiz unitária nos índices de inflação no Brasil para o período recente
Authors: Faião Thais Fernanda , Perdigão Claudia , Caldarelli Carlos Eduardo , Camara Marcia Regina Gabardo da
Published: June 2018

O objetivo desse artigo é analisar a trajetória de índices de inflação brasileiros selecionados, a fim de identificar se esses possuem comportamento inercial no período de 2000 a 2015. A presença de inércia inflacionária envolve uma questão fundamental acerca da dinâmica dos preços da economia, pois depois de estabelecidos os mecanismos de indexação, tanto a inflação passada e a sua expectativa futura, conseguem determinar os preços e salários correntes.  A análise é realizada nos índices IGP-M, IPCA, e IPCA desagregado em Alimentos e Bebidas, Produtos Industriais, Serviços e Monitorados, através da aplicação de testes de raiz unitária, nas séries em nível e nas séries dessazonalizadas por alisamento exponencial do tipo Holt-Winters. O período analisado refere-se ao pós-Plano Real, entre janeiro de 2000 e setembro de 2015. Os resultados mostraram que, de forma geral, para o período completo, apenas os índices dessazonalizados dos Produtos Industriais, dos Serviços e dos Monitorados apresentaram um comportamento inercial, enquanto que para o período recente, todos os índices, tanto em nível como dessazonalizados, apresentaram esse mesmo comportamento.
Crise no Estado do Rio de Janeiro: diagnóstico e perspectivas
Authors: Sobral Bruno Leonardo Barth
Published: June 2018

O presente artigo pretende discutir um diagnóstico alternativo e perspectivas mais razoáveis para o enfrentamento do problema econômico do Estado do Rio de Janeiro. A raiz da questão e os principais determinantes serão analisados. Além disso, critica-se a retórica das contrapartidas impostas na proposta federal e se aponta outras opções políticas. Em especial, três aspectos centrais na visão oficial e dominante serão questionados. Primeiro, atribuiu-se a crise como um problema exclusivo estadual quando a escala do problema é nacional. Segundo, o governo federal assumiu o papel simplesmente de credor sem a redistribuição de competências e recursos no âmbito do pacto federativo. Terceiro, a não articulação do problema das finanças públicas aos efeitos imprevisíveis de uma grave crise econômica.
POR UMA HISTÓRIA DA EDUCAÇÃO POLITÉCNICA : CONCEPÇÕES, EXPERIÊNCIAS E PERSPECTIVAS
Authors: Bemvindo Vitor
Published: June 2018

É comum notar, nos trabalhos do campo Trabalho-Educação, o conceito de educação politécnica ou politecnia associado à concepção marxista de educação. De fato, Marx elaborou esparsas ideias de uma pedagogia na qual a politecnia teria um papel central. No entanto, esse mesmo conceito já havia sido apropriado por distintos grupos, com diferentes sentidos políticos-pedagógicos, associados aos projetos de sociedade defendidos por cada um desses grupos. A tese “Por uma História da Educação Politécnica: Concepções, Experiências e Perspectivas” consiste em um esforço de pesquisa e análise histórica do processo de (re)construção do conceito de educação politécnica.
APRESENTAÇÃO
Authors: Rodrigues Maria Cristina
Published: June 2018

Neste número da revista TN selecionamos para a seção Memória e Documentos um material que, parafraseando sua autora, Profª Eunice Trein, nos “toca o coração”, ainda que também nos “bata no fígado”. Isso porque, como o conjunto dos artigos que compõem a revista podem atestar, não há como pensar e atuar no espaço da educação e da escola – mormente a pública – sem que uma vasta gama de sentimentos seja acionada.
UM TRIBUTO À ESCOLA PÚBLICA: MEMORIAL
Authors: Trein Eunice
Published: June 2018

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A FORMAÇÃO DO LICENCIANDO NOS INSTITUTOS FEDERAIS DO NORDESTE E O ENSINO MÉDIO INTEGRADO À EDUCAÇÃO PROFISSIONAL
Authors: Neta Olivia , Pereira Ulisséia , Silva Nina Maria
Published: June 2018

Este trabalho objetiva analisar, nos cursos de licenciatura em Letras, Matemática, Química e Geografia dos Institutos Federais de Educação, Ciência e Tecnologia da região Nordeste (IFs), as concepções de formação docente voltadas à formação para a Educação Básica, especialmente o Ensino Médio Integrado (EMI). Foram analisados questionários aplicados junto a professores e estudantes concluintes dos cursos citados acima. Concluiu-se que as concepções de formação docente e EMI presentes nos documentos dos IFs associam-se com os princípios orientadores do currículo das licenciaturas e que possuem aproximação com a concepção de formação de futuros docentes.
NGM282 Significantly Reduces Hepatic Steatosis Independent of Type 2 Diabetes (T2D) Status or Statin Usage—Results from a Phase 2 Trial in Patients with Nonalcoholic Steatohepatitis (NASH)
Authors: DEPAOLI ALEX , ROSSI STEPHEN J. , LING LEI , HARRISON STEPHEN A. , ABDELMALEK MANAL F. , JAROS MARK R. , SOMARATNE RANSI
Published: June 2018

Background: NGM282 is an engineered variant of human FGF-19 that retains bile acid and metabolic regulatory activities while eliminating the tumorigenic effects of FGF-19. Multiple preclinical models showed improvements in NASH liver histology similar to those observed post-bariatric surgery. Data from a Phase 2 trial in NASH patients showed significant reductions in hepatic steatosis, liver transaminases and markers of fibrosis that were translated to histologic benefits in NASH. Both T2D status and statin therapy have been variably associated with treatment response in NASH trials. This analysis assessed NGM282 impact on liver fat content by T2D status and statin usage.

Methods: Patients with biopsy-confirmed NASH (n=82) were randomized to NGM282 3 or 6mg or placebo for 12 weeks. The primary endpoint was ≥5% reduction in absolute liver fat content (LFC) by MRI-PDFF. Patients were stratified by T2D status at baseline and categorized as statin/no statin use (3 months prior to screening). Statin therapy was stable during the study. Treatment responses were analyzed using an ANCOVA model; NGM282 treatment arms were pooled (n=53).

Results: T2D and statin use was present in 62% and 45% of the NGM282 treated patients, respectively. There was no significant difference in LFC reduction in patients with T2D vs. no T2D (-10.4% vs.-11.2%, p=0.59) or statin use vs. no statin use (-10.7% vs. -10.7%, p=0.99) at baseline. Absolute LFC was decreased by -9.7% and -11.9% for NGM 282 3 and 6mg (p<0.001 for both), respectively. Reductions in LFC correlated with improvements in C4, HbA1c and triglycerides.

Conclusions: NGM282 is highly effective in reducing LFC, independent of T2D status or statin use. These data support the activity of NGM282 in NASH across a broad patient population. Ongoing studies will evaluate the translation of these effects into improvements in fibrosis and resolution of NASH.

Disclosure

A. DePaoli: Research Support; Self; Eli Lilly and Company, Merck Sharp & Dohme Corp. S.J. Rossi: Employee; Self; NGM Bio. Stock/Shareholder; Self; NGM Bio. L. Ling: Employee; Self; NGM Biopharmaceuticals. Stock/Shareholder; Self; NGM Biopharmaceuticals. S.A. Harrison: Research Support; Self; Novo Nordisk A/S. Consultant; Self; Novo Nordisk A/S. Research Support; Self; NGM Bio. Advisory Panel; Self; NGM Bio. Consultant; Self; NGM Bio. M.F. Abdelmalek: Advisory Panel; Self; NGM Bio. Consultant; Self; NGM Bio. Research Support; Self; NGM Bio. M.R. Jaros: Consultant; Self; NGM Bio. R. Somaratne: Employee; Self; NGM Biopharmaceuticals. Stock/Shareholder; Self; NGM Biopharmaceuticals.
Comparison of Ultra-Rapid-Acting Insulin’s Effect—Randomised, Triple Crossover Study
Authors: TAKEISHI SOICHI , TSUBOI HIROKI , TAKEKOSHI SHODO
Published: June 2018

We investigated which ultra-rapid acting insulin (URI) is the most effective in improving glycemic variability (GV)- insulin glulisine (G), insulin lispro (L) or insulin aspart (A). We calculated a required sample size of 12. Thirty type 2 diabetic patients were randomly allocated to 3 groups. On admission, preprandial and bedtime glucose levels (PB)(GL) were stabilized at 80 mg/dL level with URI (before wearing continuous glucose monitoring (FreeStyle Libre Pro) device (FLP); G) and insulin glargine 300 U/ml (G300) during the study period. Group 1: PBGL were stabilized; next, the same dose G was taken, patients wore a FLP and GV was evaluated on days 3 and 4; G was then switched to the same dose L, and GV was evaluated on days 8 and 9; finally, L was switched to the same dose A and GV was evaluated on days 13 and 14. Group 2: URI was taken in the order of L, A, G, following the same regimen. Group 3, URI was taken in the order of A, G, and L, following the same regimen. URI was administered at 08:00, 12:00, 18:00. G300 was administered at 08:00. Data collected on the second evaluation day were analysed. Test meals were given. Increased postprandial (Po) GL, Po glucose gradients, area over the glucose curve (<70 mg/dL) were significantly lower in patients on G, L, A, in that order. Start time of hypoglycemia occurrences (HO) was significantly earlier and finish time of HO was significantly later in patients on A than L. G is the best URI to improve GV.

Disclosure

S. Takeishi: None. H. Tsuboi: None. S. Takekoshi: None.
Ultra-rapid Lispro (URLi) Reduces Postprandial Glucose Excursions vs. Humalog® in Patients with T2D at Multiple Meal-to-Dose Timing Intervals
Authors: KAPITZA CHRISTOPH , LEOHR JENNIFER , LIU RONG , REDDY SHOBHA , DELLVA MARY A. , MATZOPOULOS MARK , KNADLER MARY P. , MEI TENG LOH , HARDY THOMAS , KAZDA CHRISTOF M.
Published: June 2018

URLi (LY900014), a novel ultra-rapid mealtime insulin in Phase 3 development, is shown to reduce postprandial glucose after subcutaneous injection. This 2-part, randomized, double-blind, Phase 1b study evaluated differences in PK and PD between URLi and insulin lispro (Humalog®; HL) in 30 patients with T2D. Part A used a 6-period crossover design to assess safety and compare PK and postprandial glucose response to solid mixed meal tolerance tests (MMTT) with URLi or HL at different injection to mealtime intervals (-15, 0 and +15 min). Part B evaluated safety, PK and PD during 2 weeks of multiple daily dosing (immediately before a meal) in a parallel design.In Part A, URLi reduced glucose excursions (assessed as change in area under the concentration curve vs. time [∆AUC]) during the first 2 hours (∆AUC0-2h) and entire 5 hours (∆AUC0´5h) of the MMTT regardless of dose timing (Fig). URLi reduced ∆AUC0-2h by 37% (p=0.014), 47% (p<0.0001), and 4% (p=NS) and ∆AUC0-5h by 49% (p=0.049), 105% (p<0.0001), and 29% (p=0.076) vs. HL at ´15, 0 and +15 min (significance level =0.1). The PK and PD profiles for URLi and HL were sustained after 2 weeks of outpatient dosing (Part B). More hypoglycemic events occurred with URLi during MMTTs but these were mild and mostly asymptomatic. Only a few events occurred in either group during 2 weeks of outpatient dosing. Local tolerability was similar between treatments.

Disclosure

C. Kapitza: Research Support; Self; ADOCIA, Boehringer Ingelheim GmbH, Dance Biopharm, Eli Lilly and Company, Johnson & Johnson Services, Inc., MedImmune, MSD K.K., Mylan, Nordic Bioscience, Novo Nordisk Inc., Poxel SA, Roche Diagnostics Corporation, Saniona, Sanofi-Aventis, Senseonics, Zealand Pharma A/S. J. Leohr: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company. Employee; Spouse/Partner; Accenture. Stock/Shareholder; Spouse/Partner; Accenture. R. Liu: Employee; Self; Eli Lilly and Company. Employee; Spouse/Partner; Eli Lilly and Company. S. Reddy: None. M.A. Dellva: Employee; Self; Eli Lilly and Company. M. Matzopoulos: None. M.P. Knadler: Other Relationship; Self; Eli Lilly and Company. M. Loh: Employee; Self; Eli Lilly and Company. T. Hardy: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company. C.M. Kazda: Employee; Self; Eli Lilly and Company.
Continuous Glucose Monitoring Guided Assessment of Concentrated U200 r-DNA Human Premix 30/70 Insulin
Authors: THACKER HEMANT , KESAVADEV JOTHYDEV , SINGH GURSIMRAN , SHUKLA KIRTI , PUPPALWAR GAURAV , SHRIMANKER RUPAL
Published: June 2018

Objective: With increasing longevity, obesity and late insulin initiation being common in type 2 diabetes mellitus (T2DM), concentrated insulin formulations could evolve as a choice in a subgroup of these subjects. Globally, 30% of T2DM use more than 60 units of insulin daily. U200 (r-DNA Human Insulin Premix 30/70 200IU/mL) insulin has been developed to provide sustained glucose-lowering effect and enhanced compliance without increasing the risk of hypoglycaemia. This study was conducted to assess the efficacy and safety of U200 insulin in terms of 24-hour glucose profiling using Continuous Glucose Monitoring (CGM) in T2DM.

Methods: Prospective, single-arm, open-label, multi-centre study evaluating glycaemic profile in 60 adults with T2DM administered with U200 was undertaken using CGM (iPro2, Medtronic USA) for 7 days. The endpoints assessed were time spent within acceptable glycaemic range, mean amplitude of glucose excursions (MAGE), and the duration and frequency of hypo/hyper-glycaemic periods.

Results: Mean age of subjects was 55.47 ± 9.68 (26-70) years. Mean blood glucose level was 151±23.93 (105.73-231.69) mg/dl. Blood glucose levels were within the normal limits (70-150 mg/dL) for 62.35% of time. Average numbers of hyperglycaemic and hypoglycaemic episodes observed were 2.64 and 0.22 with mean duration of 165.16 and 27.35 minutes respectively. MAGE was 77.24±22.50 (37.47-153.00) mg/dl. Medication adherence rate was 100% with no adverse event other than minor hypoglycemia reported.

Discussion and Conclusion: CGM provides 24-hour profiling of glycometabolic control and identifies fluctuations. U-200 premixed insulin demonstrated low intraday variability as measured by MAGE of 77.24 mg/dl and patients spending 62.35% of time within normal glucose limits, allowing for a more constant action with less frequent hypoglycaemic or hyperglycaemic excursions. U200 human premix insulin is effective, safe and well tolerated in T2DM patients.

Disclosure

H. Thacker: Research Support; Self; Wockhardt LTD. J. Kesavadev: Advisory Panel; Self; Novo Nordisk India Private Limited. Speaker's Bureau; Self; Novo Nordisk India Private Limited. Advisory Panel; Self; Medtronic. Speaker's Bureau; Self; Medtronic. Advisory Panel; Self; Sanofi. Speaker's Bureau; Self; Sanofi. Research Support; Self; MSD. Speaker's Bureau; Self; MSD. Advisory Panel; Self; AstraZeneca. Speaker's Bureau; Self; AstraZeneca. G. Singh: Employee; Self; Wockhardt LTD. K. Shukla: Employee; Self; Wockhardt Ltd. G. Puppalwar: Employee; Self; Wockhardt Limited, India. R. Shrimanker: Research Support; Self; Wockhardt LTD.
Treatment Patterns in Patients with Type 2 Diabetes Treated with Human Regular U-500 Insulin—A Retrospective Claims Database Analysis
Authors: CHEN JIELING , HE XUANYAO , KAO CHRISTI Y. , JACKSON JEFFREY A.
Published: June 2018

Human regular U-500 insulin (U-500R) is highly concentrated with both basal and prandial activity. It can be used as insulin monotherapy. This study sought to provide a better understanding of treatment patterns in a real-world environment for patients treated with U-500R.

Patients with type 2 diabetes initiating U-500R between 2010 and 2013 (N=1582) were selected from Truven Health MarketScan® database. The study had 3 periods: pre-index (12 month before initiation), post-index (12 month after initiation or until U-500R discontinuation), and follow-up (12 month after post-index). U-500R treatment patterns, medication possession ratio (MPR), and persistence with its contributing baseline factors were examined. The resumption of U-500R was studied during follow-up (i.e., after a gap ≥ 60 days between ends of supply from one fill to the next).

During post-index, 74.1% of patients had U-500R claims that did not overlap with other insulins. Only 7.6% had continuous U-500R claims overlapping ≥ 60 days with continuous claims of other insulins. The median U-500R average daily dose was 333 units. Among 12patients with more than one U-500R fill, 54.39% had MPR ≥80% and 26.08% patients between 60% and 80%. Within one year, 849 patients discontinued U-500R. Median time to discontinuation was 264 days. Patients 45 to 75 years old, treated with more types of insulins, or with rapid acting insulin use during pre-index were less likely to have a U-500R treatment gap (P <0.05). During follow-up, 602 (70.9%) of patients resumed U-500R. The median time from end of post-index to U-500R restart was 135 days. Out of the 733 patients with U-500R use beyond one year, 286 patients discontinued U-500R in the second year and 447 continued U-500R beyond two years.

The study suggests that U-500R is commonly used as insulin monotherapy. The observed adherence/persistence could be the result of the simplicity of U-500R regimen, which might benefit high-dose insulin-treated patients.

Disclosure

J. Chen: None. X. He: None. C.Y. Kao: None. J.A. Jackson: Other Relationship; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company.
Once-Weekly Dulaglutide (DU) and Canagliflozin (CAN) Combination Therapy in Obese T2 Diabetes (T2D) Patients—One Year Real-World Evidence from India
Authors: NIGAM ANANT
Published: June 2018

Objective: To assess the effects of addition of a combination of GLP-1 receptor agonist (GLP-1RA), injection DU 1.5 mg weekly and SGLT2 inhibitor (SGLT2i), CAN 100mg/day in T2 D obese Asian Indian patients sub-optimally controlled on metformin and other agents [sulfonylurea (SU) 71%, insulin 29%].

Methods: Impact of DU and CAN on HbA1c (A1c), weight (wt.), systolic blood pressure (SBP), lipids and dose of previous antidiabetic agents at week 16, 32 and 52 was analyzed retrospectively.

Results: Fifty-five patients (31M/24F, age 51±5.8 y, wt. 92.6±3.4 kg, BMI 31.1±2.1kg/m2, SBP 142.4±3.9mmHg, eGFR 62± 5mL/minutes/1.73m2, with 8.4±3.3 years duration of diabetes) met the inclusion criteria. In 71% subjects, A1c decreased by 1.6% [8.5±0.4 to 7.1±0.2, P<0.0001] at week 16 and dropped to 6.8±0.3 (P=0.0002) in 18% (week 32) but rose by 0.26% (P=0.0056) in 11% (week 40-52). At week 16, wt. was - 4.1 kg (92.6±3.4 to 88.5±3.6, P<0.0001). By week 32, 68% lost another 3.3±0.7 kg (P<0.0001) while 10% regained 1.1±0.6 kg (P=0.077). A drop in SBP of 4.1±0.8 mmHg (P<0.0001) was seen in 74.5% patients and 53% of these needed reduction in doses. A decrease in triglyceride (189.6±8.1 to 168.4±6.9 mg/dL, P<0.0001) and LDL-cholesterol (107.5±4.7 to 104.2±4.9 mg/dl, P=0.0004) occurred. At week 16, 50% required reduction in insulin dose and 15% stoppage. Increase in basal insulin dose/addition of prandial insulin was needed in 5% (week 39-52). By week 16, SU dose had to be halved in 56% and discontinued in others because of minor episodes of hypoglycemia. With CAN, genital and urinary tract infections were seen in 5.9% (2 F/1M) and 3.6% respectively. None had to stop therapy. With DU, nausea (18.1%), vomiting (14.5%) and diarrhea (7.2%) occurred but none had to stop therapy.

Conclusion: Combination Therapy of GLP-1 RA and SGLT2i in obese T2D patients provides statistically significant and durable glycemic control, with favorable effects on weight, BP and lipids and is also well tolerated.

Disclosure

A. Nigam: None.
Glycemic Management as the Primary Determinant of One-Year Mortality after CABG
Authors: HELLER LUCAS , ZUPA MARGARET , PERREIAH PETER L. , HARSHA RAO R.
Published: June 2018

Factors linked to mortality after coronary artery bypass graft (CABG) include post-operative hypoglycemia and graft source. However, it is unknown if there is an interaction between these two factors, namely whether arterial grafts withstand hypoglycemia better than veins after CABG. In a cohort of 1323 patients undergoing CABG with intensive insulin therapy (IIT) in the ICU, we identified graft sources, ICU glucometrics, diabetes (DM) status and one-year mortality. Glucometrics included mean BG in ICU, and hypoglycemic excursions (Incidence, Severity [nadir <40, 40-69mg/dl], Repetitive Frequency [number of excursions/patient]). The impact of different factors, individually and in combination, was analyzed by Chi-squared Automatic Interaction Detection (CHAID). One year mortality was highest in those with BG<40mg/dl in the ICU (12/26, 46%) vs. those without (67/1283, 5%, p<0.001). No other factor was significant in those with BG<40. Of those without BG<40, repetitive (≥2) excursions with BG<70mg/dL had the highest mortality (17/96, 17%, p<0.001), vs. those with one (13/190, 7%) or no excursions (37/997, 4%). Graft source was dominated by other factors in one year mortality, except for the left internal thoracic artery which was protective only in patients who had no hypoglycemia. Hyperglycemia was a contributor to mortality in patients who had a single hypoglycemic excursion <70 (ICU Mean BG>152mg/dl 4/17, 24% vs. ≤152 9/173, 5%, p=0.039) Preexisting DM was protective in patients with repetitive hypoglycemia (DM 2/43, 5% vs. 15/53 28%, p=0.003). Hypoglycemia in the ICU has a durable impact on one-year mortality post-CABG, superseding graft source, which is only significant without hypoglycemia. Severe hypoglycemia poses the greatest risk, but even mild repetitive BG<70 is a threat to one year survival.

In conclusion, hypoglycemia erases the survival benefit from arterial grafts, suggesting that it may be equally damaging, regardless of graft source, and far more durable than hitherto envisioned.

Disclosure

L. Heller: None. M. Zupa: None. P.L. Perreiah: None. R. Rao: None.
Comparison of Different Self-Adjustment Regimens of Basal Insulin in Outpatients with T2DM
Authors: HU XILING , YANG XUBIN , XU WEN , DENG HONG R. , GUO XIAODI , YAO BIN , ZENG LONGYI , WENG JIANPING
Published: June 2018

Self-adjustment of basal insulin dose were proved to be effective and widely used in clinical practice. However, no study compares the efficacy and safety of different self-adjustment regimens of basal insulin in T2DM.

T2DM with inadequate glucose control on OADs who were to start basal insulin from our outpatient clinics were enrolled and randomized to two groups. Patients in Group A were guided to adjust insulin dose 2-6U weekly; those in Group B adjusted insulin dose 2-3U every 3 days. Dose titration was based on self-monitored blood glucose (SMBG) to achieve a target FBG of 6.1mmol/L. The titration regimen is shown in Table.

A total of 648 patients aged 53.9 years old finished the 12-week visits. The baseline characteristics were even between groups. The FBG achieving rates were similar between Group A (75.7%) and Group B (74.4%). Compared with baseline, FBG and HbA1c decreased in both groups (FBG:10.7mmol/L vs. 6.6mmol/L in Group A, 10.8mmol/L vs. 6.5mmol/L in Group B; HbA1c:9.3% vs. 6.9% in group A, 9.5% vs. 6.8% in Group B, respectively, All P<0.001). The reduction of FBG (-4.1mmol/L vs. -4.2mmol/L) and HbA1c (-2.4% vs. -2.7%) were similar between groups, so as the hypoglycemic incidences (17.9% vs. 20.1%). The frequency of SMBG was higher in Group B (5.21 times/week vs. 4.69 times/week, p=0.02).

In conclusion, both self-adjustment regimens in this study are effective and safe in T2DM.Table. Insulin Titration Protocol.Fasting blood glucose(mmol/L)Dose adjustment (U)Group AGroup B<4.4-2U-2∼3U4.4-6.1No changeNo change6.2-7.8+2U+2∼3U7.9-9.9+4U+2∼3U>10.0+6U+2∼3U

Disclosure

X. Hu: None. X. Yang: None. W. Xu: None. H.R. Deng: None. X. Guo: None. B. Yao: None. L. Zeng: None. J. Weng: None.