bluuebunny/crossref_metadata_2025 huggingface dataset:
Risks to Energy Security. Visualization of Scientific Research
Authors: Hubarieva Iryna O. ,   Research Centre for Industrial Problems of Development of NAS of Ukraine, Khaustov Mykyta M. ,   Research Centre for Industrial Problems of Development of NAS of Ukraine
Published: July 2024

The aim of the article is to identify trends and key areas of research on energy security risks by conducting a structural-trend and bibliometric analysis of scientific publications. Analytical tools of scientometric databases Scopus, Web of Science, Google Trends and VOSviewer version 1.6.20 were used to conduct the study. The conducted trend analysis, using the Google Trends tools, showed a certain divergence of trends in scientific and user interest in energy security issues. In order to identify trends in the study of energy security risks using the analysis tools provided by the Scopus and Web of Science databases, the dynamics of the number of indexed publications on the subject under study, country affiliation, sectoral structure of publications were analyzed, the contribution of individual researchers in the field of energy security risks by the number of citations was allocated. The most cited articles on energy security risks, indexed in the Scopus and Web of Science databases, are devoted to: solving the problems of climate change, environmental pollution and energy instability; energy infrastructure; linking energy research with the social sciences; geography of energy transition; production of ethanol from biomass; development of hydrogen energy; identifying the causal relationship between CO2 emissions, nuclear energy consumption, renewable energy consumption and economic growth. The results of the study made it possible to identify the main scientific clusters in the field of energy security risks. Visualization of the network map of keywords made it possible to identify 8 clusters that characterize the key areas of research in the field of energy security risks: security, risk, energy, human health, climate change, renewable energy, environment. The results of the analysis contribute to the identification of new areas of research in the field of energy security risks.
International Imperatives of Financial Support for the Sustainable Development of Rural Communities
Authors: Hrytsyshen Dymytrii O. ,   Zhytomyr Polytechnic State University, Abramova Iryna V. ,   Zhytomyr Polytechnic State University
Published: July 2024

The aim of the article is the theoretical and methodological substantiation of the international imperatives of sustainable development of rural communities. The study was carried out on the basis of a systematic approach to the cognition of economic phenomena and processes. To solve certain problems, the following methods were used: system analysis – for contentualization of the evolution of international imperatives of sustainable development; comparative analysis – for the study and adaptation of foreign experience; induction and deduction – to formulate conclusions and recommendations on the issues under study. The synthesis of the works of foreign and domestic scholars made it possible to determine that the definition of «international imperative» is a multifaceted concept that combines political, economic, social and institutional aspects of society, aimed at achieving high European standards and ensuring sustainable development, at the same time it should promote the national idea and identity. It is determined that the international imperatives of sustainable development of rural territorial communities are formed on the basis of global initiatives and agreements aimed at achieving the Sustainable Development Goals (SDGs), taking into account the economic, social and environmental needs of society. A contentualization of the key imperatives of the formation of global views on the Sustainable Development Goals is performed. Emphasis is placed on the EU’s priorities for the implementation of the SDGs, the following such priorities are recognized as key ones: climate change and carbon neutrality, biodiversity conservation initiatives, measures to combat social inequality, to ensure gender equality, improving working conditions, involving all segments of the population in decision-making processes. The importance of intensifying international cooperation to solve global problems, strengthen the institutional foundations and financial mechanisms for responding to pandemics, natural disasters and other global crises is emphasized.
Johansen’s Cointegration Analysis of Some Factors of Economic Growth and Exports of Products from the Republic of Azerbaijan to Ukraine
Authors: Alizade Arzu Rafik ,   Baku State University
Published: July 2024

In the present paper, a Johansen’s cointegration analysis is carried out considering the volume of exports from Azerbaijan to Ukraine, GDP per capita of Ukraine, the openness of the economy of Ukraine and the economically active population of Azerbaijan for the period 1996-2022, also a comparative analysis of the above indicators is carried out, the characteristics of joint short-term and long-term movements are determined. In the course of research the author used the methodology of modified gravitational modeling, the econometric methodology of time series analysis, including tests for checking stationarity, the extended Dickey-Fuller test, the Granger test for the detection of causality, determining the cointegration dependence using the Johansen’s test, a Vector Error Correction Model (VECM) has been built. First, a basic modified model of gravity has been built, and the statistical adequacy of this model has been checked. A comparative analysis of two regression models was carried out after the inclusion of the trend component in one of them. The dynamic structure of regression residuals was studied and the test for heteroscedasticity and autocorrelation was carried out. It is shown that the most suitable specification for cointegration is the quadratic trend in the initial levels with a linear trend in cointegration relationships, which has led to the emergence of two cointegration vectors. As a result of the completed analysis, two cointegration relationships are obtained. The results of the impulse response functions, decomposition of dispersions and the VECM model in the form of combinations of two cointegrating vectors with the expected signs of the adjustment integers showed that the economic indicators used in the analysis for the specified period maintain cointegration in the long term with the not stable equilibrium joint movements of the factors under study.
Features of the Development of Export-Import Activity of Economic Entities of the Public Sector of the Economy
Authors: Malуarets Lyudmyla M. ,   Simon Kuznets Kharkiv National University of Economics, Norik Larisa O. , Budarin Oleksii S. , Skliar Tetiana P. ,   Simon Kuznets Kharkiv National University of Economics,   Simon Kuznets Kharkiv National University of Economics,   Simon Kuznets Kharkiv National University of Economics
Published: July 2024

Economic entities in the public sector, among other enterprises, play a key role in the resumption of export-import activities, as they have significant resources and can ensure the coordination and implementation of strategic measures in crucial sectors of the economy, thus contributing to the rapid recovery and stabilization of the country’s economic development. The aim of the article is to systematize the attributes of features of the development of export-import activities of economic entities in the public sector of the economy. The study examines the key aspects that characterize the export-import activities of economic entities in the public sector of the economy, in particular, the political context, State financial support, legal regulation and regulatory control. Special attention is paid to the strategic nature of the activities of economic entities in the public sector of the economy and their role in the implementation of the State-controlled programs and ensuring national security. The main benefits and financial mechanisms of the State support, which contribute to the effective implementation of export-import operations, have been defined. Further direction of development of this study is envisaged in carrying out an analysis of the efficiency of the State-controlled programs to support export-import activities, assessing the efficiency of foreign economic activity of economic entities in the public sector of the economy and determining the impact of international economic agreements on the development of export-import activities.
“To Make this Leap”: Understanding Relationships that Support Community College Students’ Transfer Journeys
Authors: W. Nahlik Beth E. , Hudson Tara D. , Nelson Lindsay
Published: July 2024

For too many community college students, transferring to a four-year institution for a bachelor’s degree (i.e., vertical transfer) remains an unrealized aspiration. Prior research suggests that forms of capital can assist students in realizing their goals. Therefore, we sought to explore how relationships both within and outside of their institutions serve as sources of capital to support students’ vertical transfer journeys. Utilizing a qualitative research design, we applied Putnam’s (2000) two forms of social capital (bridging and bonding) and eight social support-related constructs from Moser’s (2013) expanded transfer student capital framework to data from focus groups and interviews with 33 pre- and post-transfer students. We found that participants actively constructed a patchwork of supportive relationships with both institutional agents and individuals external to the institution, which they utilized to search for, gather, and employ transfer capital. Our findings highlight that relationships outside of institutions are as crucial as relationships within the institution as sources of capital for vertical transfer students, suggesting a need to incorporate extra-institutional relationships into transfer capital frameworks and institutional initiatives to support transfer students. We also recommend institutions invest in programs designed to build students’ social and transfer capital.
International Migrants in Counseling Literature
Authors: Xiong Yiying , Gao Boshi , Yang Zhiyuan
Published: July 2024

With the increasing number of international migrants worldwide and the emphasis on multicultural counseling competence and social justice, counseling professionals must learn more about how to work with this population. To address this need, we conducted a 36-year (1988-2023) content analysis of counseling literature focused on international migrants (i.e., immigrants and refugees) in 21 American Counseling Association-Affiliated Journals. Our analysis of 80 related journal articles aimed to explore publication trends, researched topics, and research methods related to this population, offering implications for counselors, researchers, and the counseling profession. The study underscored the significance of culturally sensitive counseling for international migrants, highlighting the necessity for advocacy efforts in the counseling profession to support the mental health needs of international migrants. We recommended that counselors remain informed about research and utilize digital and interdisciplinary approaches to enhance their support of international migrants.
A multiple criteria decision analysis to establish the use cases and candidate point of care tests to enter into a platform trial of multiple in vitro diagnostic point of care tests in the prehospital environment
Authors: Kirby Kim , Coggins Jessica , Gibson Andy , Liddiard Cathy , Moore Theresa H.M. , Savović Jelena , Mitchell Kimberley , Thompson Alexander , Benger Jonathan , Body Richard
Published: July 2024

Background There are increasing demands on Emergency Medical Services. More efficient treatment pathways are required to support conveyance decision making and patient referral in prehospital care. Point of Care testing is increasingly available and utilised across the NHS to support optimal ways of working. We aimed to design and conduct a Multiple Criteria Decision Analysis to prioritise in vitro point of care tests and use cases for inclusion in a platform trial of in vitro point of care testing in UK Emergency Medical Services. Methods We designed a Multiple Criteria Decision Analysis that included systematic scoping reviews stakeholder recruitment, two stakeholder surveys and two stakeholder workshops to scope the use cases, explore criteria and map use cases, evaluate the criteria and measure the use cases against the criteria. Results We recruited 32 stakeholders. We developed a scoring matrix with 4 criteria for scoring the use cases and 8 criteria for scoring the point of care tests and applied weighting determined from survey results. Use cases were scored by the stakeholders against 4 criteria. The 3 highest scoring use cases were point of care troponin testing in: possible Acute Myocardial Infarction, lactate testing in suspected sepsis and in trauma. We developed the process for scoring the point of care tests to be completed close to a proposed trial to allow for a changes in technology. Conclusions We successfully designed a Multiple Criteria Decision Analysis to identify use cases and candidate tests for inclusion in a future platform trial of in vitro point of care testing in UK Emergency Medical Services. We identified 3 use cases for evaluation in a platform trial of in vitro point of care testing: troponin testing in possible acute myocardial infarction, lactate testing in suspected sepsis and lactate testing to identify occult haemorrhage in trauma.
Implementasi Metode Multi Objective Optimization by Ratio Analysis dalam Menentukan Lahan dengan Jumlah Pupuk Terbanyak
Authors: Ikhwan Ali , Yuanda Ary Santri , Shiddiq Siregar Fahreza , Lesmana Reza Kurnia
Published: July 2024

PTPN III (Persero) merupakan perusahaan perkebunan yang memiliki peran strategis dalam pengelolaan sumber daya pertanian di Indonesia. Dengan fokus utama pada sektor perkebunan, PTPN III mengelola berbagai jenis tanaman seperti kelapa sawit, karet, dan teh, yang menjadi komoditas ekspor utama negara. Namun untuk mendapatkan kualitas yang terbaik maka harus di perhitungkan akumulasi agar dapat meningkatkan hasil pertanian. Penelitian ini bertujuan untuk mengoptimalkan manajemen pertanian di PTPN III melalui implementasi Sistem Pendukung Keputusan (SPK) yang memanfaatkan Metode Multi-Objective Optimization by Ratio Analysis (MOORA). Sistem Pendukung Keputusan (SPK) sangat membantu dalam menentukan dan mengambil keputusan yang tidak bisa dipilih secara acak. Sistem ini dirancang untuk memberikan rekomendasi berdasarkan evaluasi kriteria. Tujuan dari sistem ini adalah untuk menentukan blok atau bagian yang membutuhkan pupuk paling banyak tanpa usaha dan efisiensi apa pun. Hasil dari sistem ini diharapkan dapat memberikan bantuan kepada pihak PTPN III. Hasil eksperimen menunjukkan bahwa implementasi SPK dengan metode MOORA dapat membantu PTPN III dalam mengidentifikasi lahan yang paling sesuai dan menentukan jumlah pupuk terbanyak untuk meningkatkan hasil pertanian dan sebagai data acuan. Sistem ini tidak hanya meningkatkan efisiensi penggunaan pupuk tetapi juga mendukung keberlanjutan lingkungan. Keakuratan dan keandalan SPK diharapkan dapat menjadi landasan untuk pengambilan keputusan yang lebih cerdas dan adaptif dalam manajemen pertanian modern. Hasil akhir yang ditujukan adalah mendapatkan lahan yang menggunakan pupuk terbanyak berdasarkan hasil akhir yaitu Blok LL32 AFD IX (A4) dengan perolehan nilai 0,3334 dan berada di posisi pertama.
Аналітичний огляд та аналіз трендів вразливості RowHummer для різних виробників DRAM
Authors: Mazurok Valentyn , Lutsenko Vladimir
Published: July 2024

Мета роботи: провести аналітичний огляд вразливості жорстких дисків типу SSD та проаналізувати трендів вразливості RowHummer для різних виробників DRAM. Сформувати прогнози розвитку.
Результати дослідження: показано тренд до збільшення кількості вразливих до RowHummer чіпів DRAM через зменшення технічного процесу вироблення блоків пам’яті.
Практична цінність дослідження: Знайдені паттерни вразливості та основні причини RowHummer можуть сприяти кращому розумінню та покращенню методів захисту пам’яті SSD в цілому.
Цінність дослідження: Представлено дані тестування нових чіпів пам’яті кількох виробників DRAM. Також використано комбінований метод аналізу на основі минулих напрацювань в галузі захисту від RowHummer атак.
Майбутні дослідження: Це дослідження відкриває шляхи для майбутніх досліджень динаміки розвитку захисту від атак типу RowHummer та суміжних атак на пам’ять сторонніми каналами.
Тип статті: аналітична.
Розбудова національної системи оборонного планування України за Євроатлантичними принципами: воєнно-історичний аналіз
Authors: Krykun Petro , Pavlenko Victor , Korendovych Victor , Yasenko Serhii , Tkach Mykola
Published: July 2024

Мета роботи: усвідомлення ключових аспектів системи національного оборонного планування України у контексті її стратегічного курсу євроатлантичної інтеграції.
Метод: історичний та порівняльний методи оцінювання стану забезпечення сектору безпеки та оборони.
Результати дослідження: система оборонного планування в Україні вже набула загальних рис, які характерні для відповідних систем країн-членів НАТО. Водночас оборонне планування ще не досягло рівня “усталеної практики”, продовжується складний процес його реформ в умовах війни.
Теоретична цінність дослідження: узагальнення набутого досвіду оборонного планування, що базується на принципах НАТО.
Тип статті: описовий, методичний.
Метод обґрунтування вартості життєвого циклу спеціального програмного забезпечення інформаційних систем воєнного призначення
Authors: Boiko Ruslan , Rudenska Halyna
Published: July 2024

Мета роботи: розробка підходів до оцінки вартості життєвого циклу спеціального програмного забезпечення інформаційних систем воєнного призначення.
Метод дослідження: основними методами дослідження є методи аналізу, порівняння, синтезу та узагальнення.
Результати дослідження: розроблено метод обґрунтування вартості життєвого циклу спеціального програмного забезпечення інформаційних систем воєнного призначення.
Теоретична цінність дослідження: доповнено теоретичну базу для подальшого удосконалення механізмів обґрунтування вартості життєвого циклу спеціального програмного забезпечення інформаційних систем воєнного призначення.
Тип статті: описовий та аналітичний.
Vibration-controlled transient elastography for significant fibrosis in treatment-naïve chronic hepatitis B patients: A systematic review and meta-analysis
Authors: Kim Mi Na , An Jihyun , Kim Eun Hwa , Kim Hee Yeon , Lee Han Ah , Yu Jung Hwan , Jin Young-Joo , Chon Young Eun , Kim Seung Up , Jun Dae Won , Han Ji Won , Choi Miyoung
Published: July 2024

Backgrounds/Aims: Accurate diagnosis of significant liver fibrosis in patients with chronic hepatitis B (CHB) is crucial when determining whether to initiate antiviral treatment (AVT). We conduct a meta-analysis to assess the diagnostic performance of vibration-controlled transient elastography (VCTE) for significant liver fibrosis in AVT-naïve CHB patients with serum alanine transaminase (ALT) levels within 5-fold the upper limit of normal (ULN).Methods: The Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases were searched to identify studies that compared the performance of VCTE and liver biopsy (reference standard) when diagnosing significant liver fibrosis (≥F2) in AVT-naïve CHB patients with ALT within 5-fold the ULN. A hierarchical summary receiver operating characteristic curve (HSROC) and bivariate model were performed to evaluate the diagnostic performance of VCTE in the meta-analysis.Results: Eight studies (2,003 patients) were included. The summary sensitivity and specificity for diagnosis of significant liver fibrosis were 0.78 (95% confidence interval [CI], 0.66–0.86) and 0.72 (95% CI, 0.60–0.82), respectively. The HSROC for the diagnosis of significant liver fibrosis was 0.81 (95% CI, 0.72–0.86). The optimal cutoff value of VCTE for diagnosis of significant liver fibrosis was 7.7 kPa with a sensitivity of 0.64 (95% CI, 0.50–0.76) and specificity of 0.83 (95% CI, 0.72–0.90).Conclusions: Our study demonstrated that VCTE has an acceptable diagnostic performance for significant liver fibrosis in AVT-naïve CHB patients with ALT within 5-fold the ULN.
Pengembangan UI/UX Sistem Pengelolaan Inventori Menggunakan Metode Design Thinking
Authors: Widjaja Stephanus , Wicaksono Adityo Putro , Widayati Yohana Tri , Nugroho Mohamad Fajarianditya , Sandeas Dhegih
Published: July 2024

System development requires an interface design that suits the user, this is so that the system can be used fully without reducing or ignoring its main functions. Dwi Jaya Store which operates in the wholesale and retail product sales sector faces challenges such as managing suppliers which may be more than one supplier, managing product orders to suppliers based on inventory levels, managing product returns to suppliers if there are defects or damage, managing the traffic of goods from main warehouse to shops and report management. Dwi Jaya Store requires an inventory system that is easy to use but does not reduce the performance and function of the system. This research aims to produce a prototype inventory system that users use easily. This research uses the design thinking method, usability testing method, and Figma as a design tool. This research produced a prototype with a usability testing value of 78.4% which was included in the Good Application category.
Multimodal nature of pain syndrome in patients with rheumatoid arthritis in relation to the course of the disease and clinical characteristics
Authors: Zagretdinova K. R. , Gabdullina Z. N. , Sukhorukova E. V. , Zamanova E. S. , Abdrakipov R. Z. , Lapshina S. A.
Published: July 2024

Purpose of the study. To evaluate the character of pain syndrome in patients with rheumatoid arthritis in correlation with the course of the disease and comorbid pathology.

Material and methods. Sixty-six patients with a verified diagnosis of RA were examined. Of them 84.9% were women (n=56) and 15.1% men (n=10). The median age was 59 [52; 63] years. Disease activity was assessed by DAS28-CRP, with a median of 5.2 [4.54; 6.0]. Patients with moderate (31.8%) and high activity (57.5%) predominated. Disease duration averaged Me 156 [93; 246] months. Seropositive RA was suffered by 89.3% of patients. The distribution by radiological stage was as follows: 2 radiological stage – 36.3% (n=24), 3 radiological stage – 30.3% (n=20), 4 radiological stage – 33.4% (n=22). Baseline anti-inflammatory therapy was taken by 84.8% of patients (n=56), genetically engineered biological drugs were received by 28.7% (n=16). To assess the multicomponent nature of pain syndrome, the following were used: Pain Detect questionnaire — to verify neuropathic pain (NP), CSI questionnaire — to verify central sensitisation (CS). The EQ-5D-3L questionnaire was used to assess quality of life, and the Charlson index was used to assess comorbid pathology. Structural changes were assessed by modified Sharpe method on hand and foot radiographs, synovium vascularisation was assessed by joint ultrasound.

Results. 84.8% of patients had pain syndrome of mixed nature. NP correlated with pain intensity by VAS (rSp=0.458, p<0.001), DAS28-CRP (rSp=0.509, p<0.001), number of peripheral arthritis (rSp=0, 414, p<0.001), number of comorbidities (rSp=0.337, p=0.006), Charlson index (rSp=0.323, p=0.009), EQ-5D-3L (rSp= –0.268, p=0.031). CS–with VAS pain intensity (rSp=0.250, p=0.045), DAS28-CRP (rSp=0.251, p=0.044), number of painful joints (rSp=0.353, p=0.004), number of comorbidities (rSp=0.368, p=0.003), BMI (rSp=0.266, p=0.032), systolic blood pressure level (rSp=0.403, p<0.001), number of erosions on hand and foot radiographs (rSp= –0.299, p=0.016), EQ-5D-3L (rCp= –0.408, p<0.001). Patients with the presence of synovial vascularization by ultrasound had three-component pain in more than half of cases, and the combination of inflammatory pain and CS did not occur in them.

Conclusions. 84.8% of patients had multicomponent pain, with pain associated only with clinical parameters of disease activity. Associated pathology and local chronic inflammation in the joint potentiate the development of other types of pain and have a mutual negative influence.
Современные маркеры диагностики сочетания анкилозирующего спондилита и воспалительных заболеваний кишечника
Authors: Tarasova D. D. , Shilova L. N.
Published: July 2024

The problem of the combination of ankylosing spondylitis (AS) and inflammatory bowel diseases (IBD) is interdisciplinary. Modern approaches to studying this issue among rheumatologists and gastroenterologists are somewhat different. The combination of these two pathologies is a potential factor for a more severe course of these diseases. The article provides an overview of some markers that have shown high specificity in the diagnosis of AS and IBD
Peculiarities of laboratory parameters dynamics during helicobacter pylori eradication in patients with rheumatoid arthritis
Authors: Aleksandrov V. A. , Zagorodneva E. A. , Aleksandrova N. V. , Cherkesova E. G. , Shilova L. N. , Aleksandrov A. V.
Published: July 2024

Helicobacter pylori (H. pylori) is able to participate in the pathogenesis of a number of autoimmune diseases, actively maintains chronic inflammation and stimulates the systemic immune response. The virulence factor of H. pylori is cytotoxin-associated gene A (CagA) is associated with more severe inflammatory reactions, increased risk of poor clinical outcomes and is able to influence the efficacy of infection eradication in patients with rheumatoid arthritis (RA).

Purpose of the study. To evaluate laboratory parameters of H. pylori eradication efficacy in RA patients with chronic infection with the strain encoding cytotoxin-associated gene A.

Materials and methods. Forty women with RA and confirmed chronic H. pylori infection were included in the study (mean age 55.5±8.7 years; mean disease duration 13.9±9.1 years; DAS-28–3.96±0.56). CagA-IgG associated H. pylori infection was diagnosed in 22 (group I, CagA+) and not diagnosed in 18 (group II, CagA-) patients. All RA patients underwent a course of H. pylori eradication therapy.

Results. The process of H. pylori eradication had the most significant effect on laboratory parameters of CagA-negative RA patients (group II). In this group the levels of rheumatoid factor (p=0,028), C-reactive protein (CRP, p=0.001), interleukin-6 (IL-6, p=0.002), tumor necrosis factor alpha (p=0,023), angiopoietinlike protein type 3 (p=0.026) and antibodies to cyclic citrullinated peptide (ACCP, p=0,016) decreased significantly. In patients from group I (CagA+) most parameters remained practically unchanged (p>0.05), except for CRP (p=0.01) and IL-6 (p=0.011). In the short term, the success of eradication in CagA+ patients was significantly lower than in CagA- patients (p=0.033). Moreover, confirmation of successful eradication of H. pylori within the established period of time was extremely rare (p=0.009) in the combination of CagA+ and high titers of ACCP and antibodies to modified citrullinated vimentin.

Conclusions. The effectiveness of H. pylori eradication in RA patients depends on the presence of chronic infection with the strain encoding the cytotoxin-associated gene A and the level of antibodies to citrullinated proteins, which should be taken into account when choosing the therapeutic effect on H. pylori in this group.
Evaluation of Rapid Antibody Test Compatibility in COVID-19 Cases Confirmed by RT-PCR Assay
Authors: Akkaya Fırat Asuman , Kılıç Haluk , Elarslan Serkan , Bilgili Ümit , Aydın Yazıcılar Hanife , Tarıkçı Kılıç Ebru , Ayan Uğur
Published: July 2024

Aim: This study aimed to determine the reliability of rapid antibody detection test (RADT; Weimi Bio-Tech COVID-19 Antibody test) results and their compatibility with RT-PCR test in screening and control of COVID-19 infection.
Material and Methods: Our study was conducted with the permission of the Ministry of Health and the local ethics committee of our hospital. Laboratory results of 624 healthcare personnel were recorded between May 2020 and November 2020. Two nasopharyngeal specimens were collected from each case to perform RT-PCR. Simultaneously serum/plasma samples were collected for RADT testing. Our hospital's data processing system (HIS) and laboratory information system (LIS) records were used for data collection. The level of agreement between the tests was calculated using Cohen's κ index. Statistical analyses were performed using SPSS software.
Results: The mean age of the patients included in the study was 28.46 ± 2.35 years. Of all cases, 54% were female (n=337) and 46% (n=287) were male, and none of the cases had any comorbidity. Both RT-PCR and RADT were negative in 86% of the cases (n=540). RT-PCR results were positive in 13.6% (n=102) of the included cases. Of the 102 RT-PCR positive cases, 84 were positive by RADT and there were no false positive results with RADT. Sensitivity and specificity for all cases were 84.7% and 100%, respectively. In symptomatic cases, sensitivity was >95%. Conclusion: We consider that antibody tests may be useful in screening for COVID-19 in circumstances where access to RT_PCR testing may be limited, particularly in cases in the first or second week of symptomatic infection.
İntrauterin Resüsitasyon Manevraları ve Yönetimi
Authors: Gerey Seray , Türkmen Hülya , Palas Karaca Pelin
Published: July 2024

ÖZ
Amaç: Bu derleme maternal pozisyon değişikliği, maternal oksijen uygulaması, intravenöz sıvı uygulaması, uterotonik ajanların kesilmesi, vazopresör kullanımı, amniyoinfüzyon ve tokoliz uygulaması gibi intrauterin resüsitasyon tekniklerinin etki durumlarını, her birinin uygulanma şekillerini ve bu tekniklerle ilgili yapılan çalışmalardaki önerileri açıklamak amacıyla yazılmıştır.
Gereç ve Yöntemler: Bu çalışma genel bir derleme olup literatür özetlemesi yapılarak yazılmıştır.
Bulgular: İntrapartum dönem normal bir süreç olmasına rağmen, bu süreçte hem anne hem fetüs açısından riskli durumlar gelişebilmektedir. Bu riskli durumların saptanmasında, doğumun güvenli bir şekilde sürdürülmesinde ve fetal iyilik halinin bilinmesinde Elektronik Fetal Monitörizasyon (EFM) gibi çeşitli uygulamalar önemlidir. Ebelerin doğum esnasında fetal kalp atımlarını sürekli takip etmeleri doğumun sonuçları açısından gereklidir. Doğum eyleminde fetal kalp atımında normalden sapma söz konusu olduğunda fetüsün oksijenlenmesinde azalma yaşanabilmektedir. Fetal oksijenlenmenin artırılması açısından intrauterin resisütasyon manevraları uygulanmakta olup, fetüsün oksijen yetersizliğinden kaynaklanan hipoksik iskemik ensefalopati, serebral palsi ve ölüm gibi sonuçları önleyebilmektedir. Sağlık profesyonelleri tarafından fetal sağlığın tehdit altında olduğu durumlarda intrauterin resisütasyon manevralarına derhal başlanmalıdır.
Sonuç: İntrapartum dönemde uygulanan intrauterin resüsitasyon manevraları intrapartum ve postpartum dönemdeki mortalite ve morbiditeyi büyük oranda önleyebilmektedir. Bu sebeple ebelerin de fetal distresi tanıma, yönetme ve intrauterin resüsitasyon manevraları hakkında bilgi sahibi olması gereklidir.
SOME COLORING RESULTS ON SPECIAL SEMIGROUPS OBTAINED FROM PARTICULAR KNOTS
Authors: Esen Umut , Çevik Ahmet Sinan , Çitil Mehmet
Published: July 2024

Abstract. For a coloring set B ⊆ Zn, by considering the Fox n-coloring of any knot K and using the knot semigroup KS, we show that the set B is actually the same with the set C in the alternating sum semigroup AS(Zn, C). Then, by adapting some results on Fox n-colorings to AS(Zn, B), we obtain some new results over this semigroup. In addition, we present the existence of different homomorphisms (or different isomorphisms in some cases) between the semigroups KS and AS(Zn, B), and then obtained the number of homomorphisms is in fact a knot invariant. Moreover, for different knots K1 and K2
, we establish one can obtain a homomorphism or an isomorphism from the different knot semigroups K1S and K2S
to the same alternating sum semigroup AS(Zn, B)
Effect of Erythritol and Stevia Sweetener Types on The Sensory Characteristics of Siam Orange Peel – Mango Fruit Leather
Authors: Junaidi Fahmi , Hermavita Cindi Dwi , Rismaya Rina
Published: July 2024

The high prevalence of degenerative diseases has a positive correlation with excess sugar intake. Fruit leather is a processed product from fruit puree with the addition of sucrose sugar, so the sugar content is high. This study aims to determine the effect of the types of sweeteners erythritol and stevia on the sensory characteristics of the fruit leather of Siam Orange Peels-Mango. This study used a factorial complete randomized design (CRD) with two factors, the ratio of siam orange peel and mango fruit with 4 levels ((0%: 100%), (10%: 90%), (20%: 80%), (30%:70%)) and type of sweetener with 2 levels (erythritol and stevia). The sensory parameters tested included color, smell, taste, texture and overall. The results showed that the two factors and their interactions had a significant effect on all sensory attributes tested. Based on sensory analysis, fruit leather products 10% orange peel and 90% mango with erythritol sweetener type were the most preferred products on all sensory attributes.
Potential of Moringa Leaves (Moringa Oleifera L.) as a Functional Food Ingredient for Fortification of Iron Mineral Muffins
Authors: Rina Rismaya  , Eko Yuliastuti Endah Sulistyawati  , Winda Nurtiana  , Rahmawan Alfi , Fauziyyah Athiefah , Hakiki Dini Nur , Radiansyah Mohamad Rajih
Published: July 2024

This study aimed to determine the effect of adding Moringa leaf flour on the iron mineral content of muffins. This study used a factorial randomized design with a comparison factor of Moringa leaf powder concentration (0%, 3%, 6%, 9%, 12% and factors of temperature conditions and baking time ((180 ºC, 30 minutes), (200 ºC, 25 minutes)). This study was repeated with 2 experimental repetitions and 2 measurement repetitions. The results showed that the addition of Moringa leaf flour and the interaction of moringa leaf flour and baking process conditions had a significant effect on the muffin iron content. The addition of Moringa leaf powder increased the muffin mineral content. The results of this study indicated that the highest average iron content found in muffins with 12% Moringa leaves was 2.02 mg/100 g. Based on the need for iron intake for pregnant women of 9 mg/100 g, consuming 100 g of moringa muffins has fulfilled 20% of the nutritional iron needs of pregnant women. In conclusion, moringa has potential as a functional food ingredient that can increase the iron content of muffins. By conducting this research, there are new knowledge without repeating what has already been done by others.
Development of a synthetic library of humanized nanobodies for targeted IL-6 inhibition
Authors: Wang Lei , Dong Jiayi , Wu Chenlu , Yan Chenyue , Bi Chong , Xu Chengnan , Wu Yiling , Zheng Wenyun , Ma Xingyuan
Published: July 2024

Interleukin-6 (IL-6) is a cytokine that can bind to IL-6 receptor and induce pleiotropic effects. It serves as a critical biomarker, involved in inflammation amplification, tumor progression, and many other disease developments. Nanobodies, featuring small structure and high affinity, are a powerful and versatile tool in medical diagnostics and therapeutics. Here, based on a scaffold optimized for humanization and stability, we developed a synthetic phage display library that rapidly generated high-affinity and humanized nanobodies, negating the need for animal immunization. Using enhanced green fluorescent protein (eGFP) as a benchmark, we demonstrated that the library produced humanized nanobodies with high function and great intracellular stability. The library was then subjected to screening against IL-6. We identified a standout nanobody, NbL3, which exhibited high affinity (22.16 nM) and stability and significantly inhibited IL-6-enhanced migration on the human breast cancer cell MCF-7 at a relatively low concentration. NbL3’s strong blocking activity provides a promising therapeutic alternative for the IL-6-targeted intervention strategy, underscoring the broader potential of our synthetic library as a versatile platform for the development of humanized nanobodies against multiple antigens.
Modeling and analysis of crypto-backed over-collateralized stable derivatives in DeFi
Authors: Feng Zhenbang , Mohanty Hardhik , Krishnamachari Bhaskar
Published: July 2024

In decentralized finance (DeFi), stablecoins like DAI are designed to offer a stable value amidst the fluctuating nature of cryptocurrencies. We examine the class of crypto-backed stable derivatives, focusing on mechanisms for price stabilization and exemplified by the well-known stablecoin DAI from MakerDAO. For simplicity, we consider a single-collateral setting. We introduce a belief parameter to the simulation model of DAI in a previous work (DAISIM), reflecting market sentiments about the value and stability of DAI, and show that it better matches the expected behavior when this parameter is set within a particular range of values. Our methods include comparing simulated data with real-world data, focusing on monthly correlations between ETH and DAI prices and scatter plots illustrating the relationship of their price trends over time. We also propose a simple mathematical model of DAI price to explain its stability and dependency on ETH price. Finally, we analyze possible risk factors associated with these stable derivatives to provide valuable insights for stakeholders in the DeFi ecosystem.
Epigenetics in rare neurological diseases
Authors: Roberts Chris-Tiann , Arezoumand Khatereh Saei , Kadar Shahib Ashraf , Davie James R. , Rastegar Mojgan
Published: July 2024

Rare neurological diseases include a vast group of heterogenous syndromes with primary impairment(s) in the peripheral and/or central nervous systems. Such rare disorders may have overlapping phenotypes, despite their distinct genetic etiology. One unique aspect of rare neurological diseases is their potential common association with altered epigenetic mechanisms. Epigenetic mechanisms include regulatory processes that control gene expression and cellular phenotype without changing the composition of the corresponding DNA sequences. Epigenetic factors include three types of proteins, the “readers, writers, and erasers” of DNA and DNA-bound proteins. Thus, epigenetic impairments of many neurological diseases may contribute to their pathology and manifested phenotypes. Here, we aim to provide a comprehensive review on the general etiology of selected rare neurological diseases, that include Rett Syndrome, Prader-Willi Syndrome, Rubinstein-Taybi Syndrome, Huntington’s disease, and Angelman syndrome, with respect to their associated aberrant epigenetic mechanisms.
MicroRNA-21 in urologic cancers: from molecular mechanisms to clinical implications
Authors: Gan Lifeng , Zheng Liying , Zou Junrong , Luo Peiyue , Chen Tao , Zou Jun , Li Wei , Chen Qi , Cheng Le , Zhang Fangtao , Qian Biao
Published: July 2024

The three most common kinds of urologic malignancies are prostate, bladder, and kidney cancer, which typically cause substantial morbidity and mortality. Early detection and effective treatment are essential due to their high fatality rates. As a result, there is an urgent need for innovative research to improve the clinical management of patients with urologic cancers. A type of small noncoding RNAs of 22 nucleotides, microRNAs (miRNAs) are well-known for their important roles in a variety of developmental processes. Among these, microRNA-21 (miR-21) stands out as a commonly studied miRNA with implications in tumorigenesis and cancer development, particularly in urological tumors. Recent research has shed light on the dysregulation of miR-21 in urological tumors, offering insights into its potential as a prognostic, diagnostic, and therapeutic tool. This review delves into the pathogenesis of miR-21 in prostate, bladder, and renal cancers, its utility as a cancer biomarker, and the therapeutic possibilities of targeting miR-21.
Characteristics and pathogenicity of Vibrio alginolyticus SWS causing high mortality in mud crab (Scylla serrata) aquaculture in Hong Kong
Authors: Kwok Carsten Tsun-Ka , Yu Ray Chun-Wai , Hau Pak-Ting , Cheung Karry Yuen-Ching , Ng Iain Chi-Fung , Fung Joshua , Wong Ivan Tak-Fai , Yau Miranda Chong-Yee , Liu Wai-Man , Kong Hang-Kin , Siu Gilman Kit-Hang , Chow Franklin Wang-Ngai , Seto Sai-Wang
Published: July 2024

Introduction

Vibrio alginolyticus is a Gram-negative, rod-shaped bacterium belonging to the family of Vibrionaceae, a common pathogen in aquaculture animals, However, studies on its impact on Scylla serrata (mud crabs) are limited. In this study, we isolated V. alginolyticus SWS from dead mud crab during a disease outbreak in a Hong Kong aquaculture farm, which caused up to 70% mortality during summer.

Methods

Experimental infection and histopathology were used to investigate the pathogenicity of V. alginolyticus SWS in S. serrata and validate Koch’s postulates. Comprehensive whole-genome analysis and phylogenetic analysis antimicrobial susceptibility testing, and biochemical characterization were also performed.

Results

Our findings showed that V. alginolyticus SWS caused high mortality (75%) in S. serrata with infected individuals exhibiting inactivity, loss of appetite, decolored and darkened hepatopancreas, gills, and opaque muscle in the claw. Histopathological analysis revealed tissue damage and degeneration in the hepatopancreas, gills, and claw muscle suggesting direct and indirect impacts of V. alginolyticus SWS infection.

Conclusions

This study provides a comprehensive characterization of V. alginolyticus SWS as an emerging pathogen in S. serrata aquaculture. Our findings underscore the importance of ongoing surveillance, early detection, and the development of targeted disease management strategies to mitigate the economic impact of vibriosis outbreaks in mud crab aquaculture.
Improving image quality and in-stent restenosis diagnosis with high-resolution “double-low” coronary CT angiography in patients after percutaneous coronary intervention
Authors: Wu Wenjie , Zhan Hefeng , Wang Yiran , Ma Xueyan , Hou Jiameng , Ren Lichen , Liu Jie , Wang Luotong , Zhang Yonggao
Published: July 2024

Objective

This study aims to investigate the image quality of a high-resolution, low-dose coronary CT angiography (CCTA) with deep learning image reconstruction (DLIR) and second-generation motion correction algorithms, namely, SnapShot Freeze 2 (SSF2) algorithm, and its diagnostic accuracy for in-stent restenosis (ISR) in patients after percutaneous coronary intervention (PCI), in comparison with standard-dose CCTA with high-definition mode reconstructed by adaptive statistical iterative reconstruction Veo algorithm (ASIR-V) and the first-generation motion correction algorithm, namely, SnapShot Freeze 1 (SSF1).

Methods

Patients after PCI and suspected of having ISR scheduled for high-resolution CCTA (randomly for 100 kVp low-dose CCTA or 120 kVp standard-dose) and invasive coronary angiography (ICA) were prospectively enrolled in this study. After the basic information pairing, a total of 105 patients were divided into the LD group (60 patients underwent 100 kVp low-dose CCTA reconstructed with DLIR and SSF2) and the SD group (45 patients underwent 120 kVp standard-dose CCTA reconstructed with ASIR-V and SSF1). Radiation and contrast medium doses, objective image quality including CT value, image noise (standard deviation), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) for the aorta, left main artery (LMA), left ascending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA) of the two groups were compared. A five-point scoring system was used for the overall image quality and stent appearance evaluation. Binary ISR was defined as an in-stent neointimal proliferation with diameter stenosis ≥50% to assess the diagnostic performance between the LD group and SD group with ICA as the standard reference.

Results

The LD group achieved better objective and subjective image quality than that of the SD group even with 39.1% radiation dose reduction and 28.0% contrast media reduction. The LD group improved the diagnostic accuracy for coronary ISR to 94.2% from the 83.8% of the SD group on the stent level and decreased the ratio of false-positive cases by 19.2%.

Conclusion

Compared with standard-dose CCTA with ASIR-V and SSF1, the high-resolution, low-dose CCTA with DLIR and SSF2 reconstruction algorithms further improves the image quality and diagnostic performance for coronary ISR at 39.1% radiation dose reduction and 28.0% contrast dose reduction.
Adherence to optimal medical therapy and control of cardiovascular risk factors in patients after ST elevation myocardial infarction in Mexico
Authors: Villalobos-Pedroza Montserrat , Hernandez-Pastrana Sarai , Arias-Mendoza Alexandra , Latapi-Ruiz Esparza Ximena , Robles-Ledesma Mariana , Guerrero-Ochoa Alejandra , Milanes-Gonzalez Nelson Antonio , Solis-Jimenez Fabio , Sierra Gonzalez-De Cossio Alejandro , Flores-Batres Alejandro Pablo , Brindis-Aranda Arielle Astrid , Rivera-Pedrote Edgar , Jara-Nevarez Alejandra , Gonzalez-Macedo Eder , Gopar-Nieto Rodrigo , Gonzalez-Pacheco Héctor , Briseño-De la Cruz Jose Luis , Araiza-Garaygordobil Diego
Published: July 2024

Introduction

In developing countries, there is a notable scarcity of real-world data on adherence to optimal medical therapy (OMT) and its correlation with major cardiovascular adverse events (MACEs) after ST-elevation myocardial infarction (STEMI). Our study focuses on addressing this gap by evaluating adherence to OMT, examining its influence on the risk of MACEs after STEMI, and assessing subsequent cardiovascular risk factor control in Mexico.

Methods

We conducted a prospective observational study of post-STEMI patients after hospital discharge. Adherence to treatment was assessed over a median of 683 days (interquartile range: 478–833) using the Simplified Medication Adherence Questionnaire (SMAQ). Patients were followed up for 4.5 years to monitor MACEs (cardiovascular death, cardiogenic shock, recurrent myocardial infarction, and heart failure).

Results

We included 349 patients with a mean age of 58.08 years (±10.9), predominantly male (89.9%). Hypertension (42.4%), smoking (34.3%), type 2 diabetes mellitus (31.2%), obesity (22.92%), and dyslipidemia (21.4%) were highly prevalent. Adherence to OMT per SMAQ was 44.7%. The baseline clinical characteristics of adherent and non-adherent patients did not significantly differ. OMT prescription rates were as follows: acetylsalicylic acid, 91.1%; P2Y12 inhibitors, 76.5%; and high-intensity statins, 86.6%. While non-adherent patients had a numerically higher rate of MACEs (73 vs. 49 first events), there was no statistically significant difference (hazard ratio 1.30, 95% confidence interval 0.90–1.88).

Discussion

In this real-world study of patients after STEMI, we observed low adherence to OMT, a low proportion of global cardiovascular risk factor control, and a numerically higher incidence of recurrent major adverse cardiovascular events in non-adherent patients. Strategies to improve adherence to OMT and risk factor control are needed.