bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the efficacy and safety of robot-assisted and video assisted thoracic surgery for early non-small cell lung cancer: A meta-analysis
Authors: Wang Pu , Fu Yan-Hua , Qi Hong-Feng , He Peng , Wang Hai-Feng , Li Chao , Liu Xue-Cong
Published: July 2023

BACKGROUND: Radical resection of lung cancer and chemotherapy are the main methods for the treatment of early lung cancer, but surgical treatment is still the key and preferred method. OBJECTIVE: To evaluate the efficacy and safety of robotic-assisted thoracic surgery (RATS) and video assisted thoracic surgery (VATS) for non-small cell lung cancer (NSCLC). METHODS: The clinical cohort studies on the comparison of the effects of RATS and VATS in the treatment of NSCLC published in Web of Science, PubMed, The National Library of Medicine (NLM), China National Knowledge Infrastructure (CNKI) and Wanfang database from January 1, 2015 to December 31, 2022 were searched. Two researchers independently screened the literature, extracted the data, such as operation time, intraoperative conversion rate, intraoperative blood loss, number of lymph nodes dissected, and evaluated the quality of the included literature based on the Newcastle-Ottawa Scale (NOS). RevMan 5.3 software was used for Meat analysis. RESULTS: A total of 18 articles and 21,802 subjects were included. The results of the meta-analysis showed that the intraoperative blood loss of RATS was significantly less than that of VAS, and the difference was statistically significant [MD =-38.43 (95% CI: -57.71, -19.15, P< 0.001)]. Compared with VATS, the number of lymph nodes dissected in RATS was significantly higher [MD = 2.61 (95% CI: 0.47, 4.76, P= 0.02)]. The rate of conversion to thoracotomy in RATS was lower, and the difference was statistically significant [OR = 0.59 (95% CI: 0.50, 0.70, P< 0.001)]. There was no significant difference between RATS and VATS in operation time [MD =-9.34 (95% CI: -28.72, 10.04, P= 0.34)], postoperative thoracic drainage time [MD =-0.08 (95% CI: -0.42, 0.26, P= 0.64)], postoperative hospital stay [MD =-0.05 (95% CI: -0.19, 0.08, P= 0.42)], postoperative mortality [OR = 0.88 (95% CI: 0.56, 1.36, P= 0.56)] and postoperative complications [OR = 1.03 (95% CI: 0.93, 1.13, P= 0.57)]. CONCLUSION: Compared with VATS, the number of lymph nodes dissected in RATS was significantly more, and the removal of lesions and lymph nodes was more thorough and accurate. More flexible and precise operation avoids the injury of important blood vessels during operation, effectively reduces the amount of blood loss during operation, shortens the indwelling time of thoracic drainage tube, and is conducive to postoperative rehabilitation of patients.
Microleakage effect of in-office bleaching on two types of nanohybrid composites with or without surface sealer
Authors: Elrashid Afra Hassan , Alsarh Sarah Ahmad , Alotaibi Dalia Saleh , Albaqami Majed Adi , Algadhi Saleh Khalid , Alfaraj Reham Ahmad , Cicciù Marco , Minervini Giuseppe
Published: July 2023

BACKGROUND: Bleaching is a highly common method used nowadays to treat tooth discolouration because it is a significant cosmetic issue, particularly with anterior teeth, however bleaching itself results in microleakage. OBJECTIVE: This study aims to evaluate the impact of in-office bleaching on class V restoration microleakage with type 1 and type 2 composite restorations. METHODS: Three hundred and twenty healthy, caries-free removed human anterior teeth were used in this in-vitro study. All extracted teeth had their buccal and lingual surfaces uniformly prepped for class V cavities. The 120 removed teeth were divided into two groups, with Group 1 receiving Tetric N-Ceram nanohybrid composite restorations and Group 2 receiving 3 M Filtek Z350 XT nanohybrid composite restorations. Groups 1 and 2 were further broken into four more subgroups of four each. The restorations were sealed with a G-Coat Plus resin. The p-value was kept at 0.005 for the data analysis using the Chi-square and Fisher exact tests. RESULTS: Allocating microleakage among 320 study models revealed that 141 (44.1%) study samples had no microleakage, whereas 20 (6.3%), 54 (16.9%), and 105 (32.8%) study samples had microleakage up to, between, and greater than two-thirds of cavity depth. With a statistically significant p-value of 0.001, no microleakage was discovered in 85 (53.1%) lingual surfaces with Tetric N-Ceram nanohybrid composite restoration and 56 (35%) buccal surfaces with 3M Filtek Z350 XT nanohybrid composite restoration. 19.1% of samples of N-Ceram that were sealed and not bleached had no microleakage, according to analysis of microleakage across several groups. With a p-value of 0.001, the distribution of microleakage among various clusters was statistically notable. CONCLUSION: According to the findings of the study, hydrogen peroxide bleaching has an enhanced impact on micro escape during dye dispersion. Both with and without bleaching, resin coating can be utilised to minimise marginal microleakage.
Identification of potential biomarkers for progression and prognosis of renal clear cell carcinoma by comprehensive bioinformatics analysis
Authors: Dong Haonan , He Zexi , Wang Haifeng , Ding Mingxia , Huang Yinglong , Li Haihao , Shi Hongjin , Mao Lan , Hu Chongzhi , Wang Jiansong
Published: July 2023

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most common pathological type of renal cell carcinoma (RCC), and effective biomarkers will improve diagnosis and treatment. OBJECTIVE: This study investigated NPEPL1 expression in ccRCC through public databases and clinical samples and assessed its correlation with clinicopathological features and patient prognosis. METHOD: Data from The Cancer Genome Atlas and clinical specimens were gathered, NPEPL1 expression levels were analyzed; a receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of NPEPL1; and clinicopathological data was used to study the correlations between expression and clinical parameters. NPEPL1’s prognostic value was appraised using a Kaplan–Meier (K–M) survival curve, Cox regression analysis, and a nomogram model; Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of differently expressed genes between tissues with high and low NPEPL1 expression were used to estimate the underlying mechanisms involved. RESULTS: NPEPL1 was significantly higher-expressed in ccRCC tissue. ROC analysis showed that NPEPL1 had noteworthy diagnostic efficacy. NPEPL1 expression was closely related to clinicopathological parameters, such as T and M stage. K–M analysis showed that overall survival was significantly shortened with high NPEPL1 expression. Cox regression analysis showed that NPEPL1 expression was an independent risk factor predicting overall survival. The nomogram showed a significantly high clinical value in predicting the 1-, 3-, and 5-year survival probabilities in ccRCC. GO and KEGG enrichment analysis suggested that NPEPL1 may promote the occurrence and development of ccRCC via the Ras signaling and other pathways. CONCLUSION: NPEPL1 expression in ccRCC was higher than that in normal kidney tissues and was significantly associated with advanced clinical stage and poor prognosis. Therefore, NPEPL1 is a promising prognostic biomarker.
Exploring the aspirations, expectations and impediments of ‘dental anaesthesiology’ as a medical and dental speciality: A scoping review
Authors: Prabhu Namdeo , Issrani Rakhi , Bader Alzarea K. , Albulayhid Amjad Abdulrahman S. , Alfayyadh Afrah Yousef , Alruwaili Khluod Khalifah , Alruwaili Khalid Hussain Ali , Albalawi Ahmed Saleh
Published: July 2023

BACKGROUND: Local anaesthesia is the anaesthetic technique most frequently used in dentistry. Advanced anaesthetic treatments like conscious sedation and/or general anaesthesia are required for major dental surgical procedures. Although general dentists are capable of administering local anaesthesia, additional training is needed for advanced anaesthetic procedures. It is generally disputed whether advanced anaesthetic techniques should be related to one or two dental specialties or whether they should receive a separate degree. OBJECTIVE: This paper aims at introducing the field of ‘dental anaesthesiology’ in routine dental practice as applicable within laws laid down for dental and medical specialities. METHODS: Publications, articles and mouthpieces relevant to the topic of dental anaesthesiology were identified using various search engines like MEDLINE (via PubMed), EMBASE, and Web of Science. The terms used for the search were ‘Dental anaesthesiology’, ‘General anaesthesia’, and ‘Dental care’. Articles about dental treatment done under anaesthesia were only considered describing various anaesthesia techniques. Additionally, the authors being regular caregivers of dentistry including oral and maxillofacial surgeon have shared their personal experiences and information on the said theme. RESULTS: In total, 127 articles were found of which 33 were available as full texts. Unrelated articles from the available full text were excluded. Finally, 17 studies were incorporated into the review. Majority of dental anaesthesiologist has a positive and favourable attitude towards the profession. Pediatric dentistry, oral and maxillofacial surgery, and special needs dentistry are the fields with the highest service demand. Also, the field is lucrative if the practitioner is refined and provides sophisticated services. It is easier and time saving to train the dentists, especially the ones with oral and maxillofacial surgery background. CONCLUSION: A degree of dental anaesthesiologist will open new doors to the budding dentist seeking for jobs or wanting to provide the best outcome.
Psychometric properties of the Persian version of the Fleishman Job Analysis Survey (FJAS)
Authors: Ghanbari Zahra , Abouee-Mehrizi Amirreza , Rasoulzadeh Yahya , Hokmabadi Rajabali
Published: July 2023

BACKGROUND: Job analysis is one of the most important and widely used processes to determine job duties, identify and reduce potential risks, and specify the skills and facilities required for each job at the highest level of occupational safety and health. OBJECTIVE: This study aimed to perform psychometric analyses of the Persian version of the Fleishman Job Analysis Survey (FJAS). METHODS: A cross-sectional study was conducted among 31 drivers. Participants were selected by random sampling. Ten occupational health and ergonomics experts confirmed the validity of the survey. First, we calculated the survey’s CVR and CVI. Then, we used ICC and Cronbach’s alpha coefficients to evaluate the survey’s reliability. Data analysis utilized SPSS 21. RESULTS: 78% of the participants were male and 22% were female. The mean age±SD of the participants was 39.1±11.82 years. The reliability and validity of the short version survey showed that the value of ICC and Cronbach’s alpha coefficient was 0.96, and CVR was 0.75. Moreover, the values of CVI for simplicity, clarity, and relevance were 0.87, 1, and 0.73, respectively. The long version’s ICC and CVR were 0.96 and 0.97, respectively. Simplicity, clarity, and relevance CVI scores were 0.9, 0.94, and 0.95. CONCLUSION: The results of this study showed that the Persian version of the Fleischman Job Analysis Survey has the necessary validity and reliability for job analysis, so it can be used for driving professional or research purposes. Moreover, this survey is an effective tool for obtaining accurate and complete knowledge of job tasks and requirements.
Do worksite health promotion programs (WHPP) influence presenteeism among employees? A systematic review1
Authors: Støren Pernille G. , Grønningsæter Hilde
Published: July 2023

BACKGROUND: Worksite health promotion programs (WHPP) aiming to reduce presenteeism are rapidly increasing. However, program-efficacy seems impaired by lack of conceptual understanding and theoretical frameworks related to presenteeism. OBJECTIVES: To study (1) the concept of presenteeism, (2) the causes of the phenomenon and (3) which WHPP affect presenteeism. METHODS: We followed the PRISMA 2020 guidelines for mapping relevant literature in seven databases. The main search-terms were “worksite”, “WHPP”, “presenteeism”, “employee productivity” and “interventions”. Reviews and review of reviews were included and analysed according to research questions and ecological theory. RESULTS: Of 2196 studies identified, 14 reviews were included, comprising 1390 single studies. Conceptually, presenteeism was poorly defined, mostly related to productivity/performance limitations due to ill health. Factors causing presenteeism addressed individual health or lifestyle (78%), and, to a lesser extent work and organisational factors (management/job stress) (22%). Forty-five highly diverse WHPP were identified, about 90% focusing health outcomes. 22/45 WHPP affected presenteeism/productivity positively. Multi-component WHPP implemented at multi levels accounted for 55%. Single-component programs, implemented at individual level, were mostly targeting health-risk subgroups. No specific WHPP seems preferable. Methodological quality seems highly associated with worksite intervention-efficacy. CONCLUSION: Increased telework opportunities due to COVID-19 experiences has affected working conditions worldwide, for better and worse, requiring adaptions at employee, management, organisational and socio-cultural levels. Our results showed high program diversity, several adaptable to future needs (e.g., digital solutions), however hampered by narrow focus on individual health. Future research should focus on theory-based high quality multilevel WHPP comprising contextual, work, and organisational factors.
Insights on just culture from seafarers and shipping companies in Indonesia: An exploratory study
Authors: Putra Ade Mardani , Arce Maria Carrera , Baumler Raphael
Published: July 2023

BACKGROUND: Just culture aspires to prompt organizational learning from enhanced feedback by frontline operators. Just culture requires mechanisms to eliminate fear and sanction but not accountability when reporting safety-related issues. Adopted in sectors such as aviation, just culture remains an underdeveloped field in the maritime sector. OBJECTIVE: This study explores how some pre-requisites for a just culture (i.e., ease of reporting, motivation to report, and trust) are perceived and potentially implemented by seafarers’ and shipping company safety representatives in Indonesia. METHODS: Semi-structured interviews were used to collect qualitative data in an exploratory study involving eleven active seafarers and four safety managers from shipping companies in Indonesia. RESULTS: The conditions for ease of reporting seem present, at least on paper. Shipping companies receive one to two near-miss reports per month. However, incidents seem to be underreported. It appears that companies are unsuccessful in establishing the motivation and trust necessary to enhance safety event reporting. CONCLUSION: The study suggests that the concept of a just culture is not well understood among certain Indonesian shipping companies. The main barriers to implementing a just culture relate to hierarchical structures in the industry, frequent crew changes, blame culture, and lack of anonymous reporting for safety concerns.
Promoting the Development of Conservation Engineering Technology for Scarce Medicinal Plants to Support Yunnan in Winning the "Battle for Biodiversity"
Authors: Zhang Pei
Published: July 2023

The construction of ecological civilization is a fundamental plan for the sustainable development of the Chinese nation. The Chinese nation has always respected and loved nature, and the Chinese civilization that has lasted for more than 5,000 years has bred a rich ecological culture. Many concepts emphasize the unity of heaven, earth and man, and link natural ecology with human civilization, act according to the laws of nature, use resources in a timely manner and in moderation, expressing our ancestors' important understanding of dealing with the relationship between man and nature. This paper analyzes the conservation engineering technology of scarce medicinal plants from the perspective of ecological civilization construction and proposes a series of actions to protect Yunnan's biodiversity.
Prediksi Jarak Luncur Longsoran Berdasarkan Parameter Geometri Lereng dan Tipe Batuan
Authors: Apriani Dyah Wahyu , Salsabila Aulia Putri , Khala Christianto Credidi , Silfiani Mega
Published: July 2023

landslide disaster. Based on this fact, a method is needed to predict the range of landslides to minimize the impact of disaster losses. The empirical statistical method is one of the methods that can be used to predict landslides by taking input data from the history of previous landslide events. This research aims to find the best modeling form for sliding distance prediction and which parameters influence a landslide's sliding distance prediction. This study used multiple linear regression methods. The data used in this study are geometric slope parameters in the form of slope height (H), original slope (θ), landslide area (A), and rock type (RT). The data was taken from the 2015-2021 PVMBG landslide investigation report and used the Google Earth and Global Mapper program. Based on the analysis of the best empirical model that can predict the sliding distance of a landslide log Lmax = 0,387 – 0,097 RT + 0,230 log H + 0,458 log A – 0,220 tan θ with an R2 value of 0,94 and an average estimated error of 31,56%. The parameter that has the most influence on the prediction of sliding distance is the area affected by the landslide (A).
Pengaruh Set Back Terhadap Kinerja Batas Layan Struktur Dengan Soft Storey Akibat Beban Gempa
Authors: Fajar Muhammad Nur , Purnama Mizwan , Purwantoro Albertus Didik Setyo , Arifin Herlina , Maysyurah Alfina
Published: July 2023

Seiring perkembangan zaman pembangunan mengalami perkembangan yang sangat pesat, yang mana dalam perencanaannya menambahkan unsur arsitektural seperti ketidakberaturan geometri dan bangunan soft storey. Di Sorong terdapat sesar aktif, sehingga tantangan untuk membangun gedung dengan resiko gempa. Tujuan penelitian adalah untuk mengetahui pengaruh displacement dan drift ratio serta kinerja struktur pada gedung bertingkat dengan efek soft storey pada bangunan set back dan tanpa set back. Pada penelitian bangunan dimodelkan dengan maksimal 7 lantai dengan tinggi total bangunan 37 m menggunakan software analisis struktur, yang juga digunakan untuk menganalisis gaya seismik dengan cara spektroskopi refleksi beragam respon. Ada dua model yang diteliti yaitu bangunan dengan efek soft storey tanpa set back dan bangunan dengan efek soft storey dengan set back. Berdasarkan penelitian yang telah dilakukan maka diperolehlah hasil displacement dan drift ratio terbesar terjadi pada bangunan soft storey dengan set back dibanding dengan bangunan gedung soft storey tanpa set back. Namun tetap dalam batas aman berdsasarkan kinerja batas layan akibat beban gempa.
Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease
Authors: Pereira Maria João , Ayana Rajagopal , Holt Matthew G. , Arckens Lutgarde
Published: July 2023

Astrocytes are the major glial cell type in the central nervous system (CNS). Initially regarded as supportive cells, it is now recognized that this highly heterogeneous cell population is an indispensable modulator of brain development and function. Astrocytes secrete neuroactive molecules that regulate synapse formation and maturation. They also express hundreds of G protein-coupled receptors (GPCRs) that, once activated by neurotransmitters, trigger intracellular signalling pathways that can trigger the release of gliotransmitters which, in turn, modulate synaptic transmission and neuroplasticity. Considering this, it is not surprising that astrocytic dysfunction, leading to synaptic impairment, is consistently described as a factor in brain diseases, whether they emerge early or late in life due to genetic or environmental factors. Here, we provide an overview of the literature showing that activation of genetically engineered GPCRs, known as Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), to specifically modulate astrocyte activity partially mimics endogenous signalling pathways in astrocytes and improves neuronal function and behavior in normal animals and disease models. Therefore, we propose that expressing these genetically engineered GPCRs in astrocytes could be a promising strategy to explore (new) signalling pathways which can be used to manage brain disorders. The precise molecular, functional and behavioral effects of this type of manipulation, however, differ depending on the DREADD receptor used, targeted brain region and timing of the intervention, between healthy and disease conditions. This is likely a reflection of regional and disease/disease progression-associated astrocyte heterogeneity. Therefore, a thorough investigation of the effects of such astrocyte manipulation(s) must be conducted considering the specific cellular and molecular environment characteristic of each disease and disease stage before this has therapeutic applicability.
Meta-analysis of the effects of denosumab and romosozumab on bone mineral density and turnover markers in patients with osteoporosis
Authors: Hu Mingwei , Zhang Yifan , Guo Jianjun , Guo Cuicui , Yang Xue , Ma Xue , Xu Hao , Xiang Shuai
Published: July 2023

Purpose

To assess the alterations in bone mineral density and bone turnover marker concentrations following the administration of denosumab and romosozumab therapies in patients with osteoporosis.

Methods

PubMed was searched for studies published until January 28, 2023, that investigated the clinical efficacy and bone turnover marker changes of denosumab and romosozumab in the treatment of osteoporosis, with a minimum follow-up of 3 months in each study. Studies were screened, and data on changes in bone mineral density (BMD), P1NP, and TRACP-5b levels after treatment were extracted and included in the analysis.

Results

Six studies were analyzed. At 3 months after treatment, the romosozumab group showed greater changes in lumbar BMD and bone turnover markers. BMD of total hip and femoral neck was relatively delayed. Beginning at 6 to 12 months, romosozumab showed greater changes in bone mineral density and markers of bone turnover.

Conclusion

Both romosozumab and denosumab have antiosteoporotic effects, with greater effects on BMD and bone turnover markers observed within 12 months of romosozumab treatment.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero, identifier CRD42023395034.
Critical evaluation of biochar effects on methane production and process stability in anaerobic digestion
Authors: Hu Jiahui , Stenchly Kathrin , Gwenzi Willis , Wachendorf Michael , Kaetzl Korbinian
Published: July 2023

Biochar is an emerging biomaterial for managing residual biomass while simultaneously sequestering carbon. To extend the biochar value chain, applying biochar to enhance anaerobic digestion (AD) processes is gaining attention in the context of a circular economy and cascading use of biomass. However, the comparative effects of various biochar dosages under normal and severe AD conditions are still unclear. To further our understanding of its potential application, this work investigated the impact of adding various biochar dosages on AD processes under normal and high substrate loadings. Three inoculum-to-substrate ratios (ISRs): one representing normal substrate loading (ISR 2) and two representing substrate overloading (ISR 1 and 0.5) were investigated. Each substrate loading rate was tested with a biochar dosage of 0% (control), 10%, and 25% based on substrate volatile solids. The results revealed that under the severe condition of high substrate overload (ISR 0.5), a high biochar dosage of 25% significantly increased cumulative methane production by 5.6% (p = 0.06) when compared to the control. Under the same condition (ISR 0.5, 25%), the time required to achieve a particular extent of ultimate methane potential was significantly reduced (p = 0.04), indicating that the methane production rate was increased. At ISR 0.5, the increase of process stability was also significant with 25% biochar addition, while the control (0%) and 10% biochar addition exhibited high variance among replicates. However, biochar did not affect AD processes under normal substrate loading (ISR 2) and mild substrate overload (ISR 1). Thus, a positive effect of biochar on the AD process was only observed under severe conditions with the highest biochar dosage. Future works should consider optimising substrate loadings and biochar dosages under real conditions when testing the practical application of biochar addition in AD processes.
Characterization and source of fluorescent dissolved organic matter in the Western Arctic Ocean: new insights from the 2019 summer study
Authors: Jeon Mi Hae , Jung Jinyoung , Park Mi Ok , Cho Kyoung-Ho , Lee Youngju , Yang Eun Jin , Kang Sung-Ho
Published: July 2023

Increase in river discharge and seasonal primary production and decline in sea ice coverage in the Arctic Ocean in summer can significantly affect the distribution and composition of dissolved organic matter (DOM). This study aimed to enhance the current available knowledge about the impacts of environmental changes on the characteristics of DOM in the rapidly changing Arctic Ocean. Seawater samples were collected from the western Arctic Ocean during the summer of 2019 and analyzed for fluorescent DOM (FDOM), dissolved organic carbon (DOC), and stable oxygen isotope (δ18O) content in conjunction with biophysical properties. We identified two humic-like (C1 and C2) and one protein-like (C3) components using fluorescence excitation-emission matrix coupled with parallel factor (EEM–PARAFAC) analysis. Remarkably high intensities of humic-like FDOM were found in the upper halocline layer (32 < salinity < 33.5 psu, at depths between 50–200 m) with high inorganic nutrient concentrations and low N* values, indicating that the humic-like FDOM was supplied from the shelf sediment. Furthermore, shoaling of the upper halocline layer brought high levels of humic-like FDOM to the euphotic zone, resulting in an increased probability of photodegradation of humic-like FDOM due to exposure to solar radiation in the surface layer. Tryptophan-like FDOM was positively correlated with river water fraction (friver) and riverine DOC but not with chlorophyll-a (Chl-a) and heterotrophic bacterial abundance, indicating river discharge as a potential additional source of tryptophan-like FDOM. The correlation coefficients between tryptophan-like FDOM and river water parameters (friver and riverine DOC) differed across the Chukchi Sea, Chukchi Borderland, and East Siberian Sea, implying that the influence of river discharge on tryptophan-like FDOM is region-dependent. An increase in river discharge in future might lead to a greater supply of tryptophan-like FDOM, impacting the dynamics of DOM cycling in the western Arctic Ocean.
Detecting turbid plumes from satellite remote sensing: State-of-art thresholds and the novel PLUMES algorithm
Authors: Tavora Juliana , Gonçalves Glauber Acunha , Fernandes Elisa Helena , Salama Mhd. Suhyb , van der Wal Daphne
Published: July 2023

Turbid coastal plumes carry sediments, nutrients, and pollutants. Satellite remote sensing is an effective tool for studying water quality parameters in these turbid plumes while covering a wide range of hydrological and meteorological conditions. However, determining boundaries of turbid coastal plumes poses a challenge. Traditionally, thresholds are the approach of choice for plume detection as they are simple to implement and offer fast processing (especially important for large datasets). However, thresholds are site-specific and need to be re-adjusted for different datasets or when meteorological and hydrodynamical conditions differ. This study compares state-of-the-art threshold approaches with a novel algorithm (PLUMES) for detecting turbid coastal plumes from satellite remote sensing, tested for Patos Lagoon, Brazil. PLUMES is a semi-supervised, and spatially explicit algorithm, and does not assume a unique plume boundary. Results show that the thresholds and PLUMES approach each provide advantages and limitations. Compared with thresholds, the PLUMES algorithm can differentiate both low or high turbidity plumes from the ambient background waters and limits detection of coastal resuspension while automatically retrieving metrics of detected plumes (e.g., area, mean intensity, core location). The study highlights the potential of the PLUMES algorithm for detecting turbid coastal plumes from satellite remote sensing products, which can have significantly positive implications for coastal management. However, PLUMES, despite its demonstrated effectiveness in this study, has not yet been applied to other study sites.
Multi-session transcutaneous auricular vagus nerve stimulation for Parkinson's disease: evaluating feasibility, safety, and preliminary efficacy
Authors: Lench Daniel H. , Turner Travis H. , McLeod Colin , Boger Heather A. , Lovera Lilia , Heidelberg Lisa , Elm Jordan , Phan Anh , Badran Bashar W. , Hinson Vanessa K.
Published: July 2023

Background

In pre-clinical animal models of Parkinson's disease (PD), vagus nerve stimulation (VNS) can rescue motor deficits and protect susceptible neuronal populations. Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a non-invasive alternative to traditional invasive cervical VNS. This is the first report summarizing the safety, feasibility, and preliminary efficacy of repeated sessions of taVNS in participants with PD.

Objectives

To evaluate the feasibility, safety, and possible efficacy of taVNS for motor and non-motor symptoms in mild to moderate PD.

Methods

This is a double-blind, sham controlled RCT (NCT04157621) of taVNS in 30 subjects with mild to moderate PD without cognitive impairment. Participants received 10, 1-h taVNS sessions (25 Hz, 200% of sensory threshold, 500 μs pulse width, 60 s on and 30 s off) over a 2-week period. Primary outcome measures were feasibility and safety of the intervention; secondary outcomes included the MDS-UPDRS, cognitive function and self-reported symptom improvement.

Results

taVNS treatment was feasible, however, daily in-office visits were reported as being burdensome for participants. While five participants in the taVNS group and three in the sham group self-reported one or more minor adverse events, no major adverse events occurred. There were no group differences on blood pressure and heart rate throughout the intervention. There were no group differences in MDS-UPDRS scores or self-reported measures. Although global cognitive scores remained stable across groups, there was a reduction in verbal fluency within the taVNS group.

Conclusions

taVNS was safe, and well-tolerated in PD participants. Future studies of taVNS for PD should explore at-home stimulation devices and optimize stimulation parameters to reduce variability and maximize engagement of neural targets.
The use of alteplase, although safe, does not offer clear clinical advantages when mild stroke is non-disabling
Authors: Merlino Giovanni , Nesi Lorenzo , Vergobbi Pietro , Scanni Marco Domenico , Pez Sara , Marziali Alessandro , Tereshko Yan , Sportelli Giuseppe , Lorenzut Simone , Janes Francesco , Gigli Gian Luigi , Valente Mariarosaria
Published: July 2023

Introduction

It is unknown whether alteplase is effective and safe in patients with mild acute ischemic stroke (AIS). Determining whether symptoms are “disabling” or not is a crucial factor in the management of these patients. This study aimed to investigate the efficacy and safety of alteplase in patients with mild, non-disabling AIS.

Methods

We included all consecutive patients admitted for AIS at our institution from January 2015 to May 2022 who presented a baseline NIHSS score of 0–5 and fit the criteria to receive intravenous thrombolysis. In order to select only subjects with non-disabling AIS, we excluded patients who scored more than 1 point in the following NIHSS single items: vision, language, neglect, and single limb. Patients who scored at least 1 point in the NIHSS consciousness item were excluded as well. This study is a retrospective analysis of a prospectively collected database.

Results

After the application of the exclusion criteria, we included 319 patients, stratified into patients receiving and not receiving alteplase based on non-disabling symptoms. The two groups were comparable regarding demographic and clinical data. Rates of a 3-month favorable outcome, defined as a 3-month mRS score of 0–1, were similar, being 82.3% and 86.1% in the treated and untreated patients, respectively. Hemorrhagic complications and mortality occurred infrequently and were not affected by alteplase treatment.

Discussion

This observational study suggests that the use of alteplase, although safe, is not associated with a better outcome in highly selected patients with non-disabling AIS.
Chromatic pupillometry isolation and evaluation of intrinsically photosensitive retinal ganglion cell-driven pupillary light response in patients with retinitis pigmentosa
Authors: Zhao He , Wang Hao , Zhang Minfang , Weng Chuanhuang , Liu Yong , Yin Zhengqin
Published: July 2023

Purpose

The pupil light response (PLR) is driven by rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs). We aimed to isolate ipRGC-driven pupil responses using chromatic pupillometry and to determine the effect of advanced retinitis pigmentosa (RP) on ipRGC function.

Methods

A total of 100 eyes from 67 patients with advanced RP and 18 healthy controls (HCs) were included. Patients were divided into groups according to severity of visual impairment: no light perception (NLP, 9 eyes), light perception (LP, 19 eyes), faint form perception (FFP, 34 eyes), or form perception (FP, 38 eyes). Pupil responses to rod-weighted (487 nm, −1 log cd/m2, 1 s), cone-weighted (630 nm, 2 log cd/m2, 1 s), and ipRGC-weighted (487 nm, 2 log cd/m2, 1 s) stimuli were recorded. ipRGC function was evaluated by the postillumination pupil response (PIPR) and three metrics of pupil kinetics: maximal contraction velocity (MCV), contraction duration, and maximum dilation velocity (MDV).

Results

We found a slow, sustained PLR response to the ipRGC-weighted stimulus in most patients with NLP (8/9), but these patients had no detectable rod- or cone-driven PLR. The ipRGC-driven PLR had an MCV of 0.269 ± 0.150%/s and contraction duration of 2.562 ± 0.902 s, both of which were significantly lower than those of the rod and cone responses. The PIPRs of the RP groups did not decrease compared with those of the HCs group and were even enhanced in the LP group. At advanced stages, ipRGC responses gradually became the main component of the PLR.

Conclusion

Chromatic pupillometry successfully isolated an ipRGC-driven PLR in patients with advanced RP. This PLR remained stable and gradually became the main driver of pupil contraction in more advanced cases of RP. Here, we present baseline data on ipRGC function; we expect these findings to contribute to evaluating and screening candidates for novel therapies.
NIDM-Terms: community-based terminology management for improved neuroimaging dataset descriptions and query
Authors: Queder Nazek , Tien Vivian B. , Abraham Sanu Ann , Urchs Sebastian Georg Wenzel , Helmer Karl G. , Chaplin Derek , van Erp Theo G. M. , Kennedy David N. , Poline Jean-Baptiste , Grethe Jeffrey S. , Ghosh Satrajit S. , Keator David B.
Published: July 2023

The biomedical research community is motivated to share and reuse data from studies and projects by funding agencies and publishers. Effectively combining and reusing neuroimaging data from publicly available datasets, requires the capability to query across datasets in order to identify cohorts that match both neuroimaging and clinical/behavioral data criteria. Critical barriers to operationalizing such queries include, in part, the broad use of undefined study variables with limited or no annotations that make it difficult to understand the data available without significant interaction with the original authors. Using the Brain Imaging Data Structure (BIDS) to organize neuroimaging data has made querying across studies for specific image types possible at scale. However, in BIDS, beyond file naming and tightly controlled imaging directory structures, there are very few constraints on ancillary variable naming/meaning or experiment-specific metadata. In this work, we present NIDM-Terms, a set of user-friendly terminology management tools and associated software to better manage individual lab terminologies and help with annotating BIDS datasets. Using these tools to annotate BIDS data with a Neuroimaging Data Model (NIDM) semantic web representation, enables queries across datasets to identify cohorts with specific neuroimaging and clinical/behavioral measurements. This manuscript describes the overall informatics structures and demonstrates the use of tools to annotate BIDS datasets to perform integrated cross-cohort queries.
Recent advances in the development of CB1R selective probes
Authors: Amenta Arianna , Caprioglio Diego , Minassi Alberto , Panza Luigi , Passarella Daniele , Fasano Valerio , Imperio Daniela
Published: July 2023

Cannabinoid subtype 1 receptors (CB1Rs) are an important class of G protein-coupled receptors (GPCRs) belonging to the endocannabinoid system. CB1Rs play a crucial modulatory role in the functioning of other neurotransmitter systems and are involved in a wide range of physiological functions and dysfunctions; thus, they are considered one of the most important targets for drug development, as well as diagnostic purposes. Despite this, only a few molecules targeting this receptor are available on the pharmaceutical market, thus emphasizing the need to gain a deeper understanding of the complex activation pathways of CB1Rs and how they regulate diseases. As part of this review, we provide an overview of pharmacological and imaging tools useful for detecting CB1Rs. Herein, we summarize the derivations of cannabinoids and terpenoids with fluorescent compounds, radiotracers, or photochromic motifs. CB1Rs’ molecular probes may be used in vitro and, in some cases, in vivo for investigating and exploring the roles of CB1Rs together with the starting point for the development of CB1R-targeted drugs.
Post-activation performance enhancement of flywheel training on lower limb explosive power performance
Authors: Fu Keqi , Chen Lingying , Poon Eric Tsz-Chun , Wang Rou , Li Qian , Liu Haochong , Ho Indy Man Kit
Published: July 2023

The study aimed to investigate the post-activation performance enhancement (PAPE) of flywheel training (FT) on lower limb explosive power performance. Using a randomized crossover design, 20 trained men (age = 21.5 ± 1.4 years; training experience 5.5 ± 1.2 years) completed seven main conditions after three familiarization sessions. The first three conditions tested the PAPE of the FT on the counter movement jump (CMJ) under three different inertial loads (0.041 kg·m2 as L; 0.057 kg·m2 as ML; and 0.122 kg·m2 as P), whereas the following four conditions tested the PAPE of FT on the 30 m sprint, which consisted of three inertial loads (L, ML, and P) and a control condition. Participants were required to perform the CMJ or 30 m sprint at baseline (Tb) and immediately (T0), 4 min (T4), 8 min (T8), 12 min (T12), and 16 min (T16) after exercise, respectively. The results of the CMJ conditions showed that PAPE peaked at T4 (p < 0.01) and almost subsided at T12 (p > 0.05) in ML and P conditions. Meanwhile, PAPE appeared earlier in the P condition, and the effect was more significant (P:ES = 1.09; ML:ES = 0.79). 30 m sprint results showed significant improvement only in the ML condition. The PAPE peaked at T4 (p < 0.05, ES = −0.47) and almost subsided at T8 (p > 0.05). It was mainly due to the significant enhancement of the 10–30 m segmental timing performance at T4 (p < 0.05, ES = −0.49). This study indicates that the size of the inertial load could influence the magnitude of the PAPE produced by the explosive force of the lower limb. The PAPE of the vertical explosive force increased with increasing inertial load, but the PAPE of the horizontal explosive force did not appear at the maximum inertial load. The most effective elicitation of the PAPE was at 4–8 min after the FT.
In vitro assessment of Bacillus subtilis FJ3 affirms its biocontrol and plant growth promoting potential
Authors: Jan Faisal , Arshad Hamza , Ahad Mehreen , Jamal Asif , Smith Donald L.
Published: July 2023

Bacillus species and their metabolites have potential alternative uses as chemical pesticides that can limit the growth of potential plant pathogens and enhance crop productivity. The aim of this study was to investigate the potential of Bacillus subtilis FJ3 for promoting plant growth and controlling fungal plant pathogens. The study evaluated the ability of the strain to promote plant growth in vitro by characterizing its growth-promoting traits, which included the production of hydrolytic enzymes, indole acetic acid, siderophores, biofilm formation, and phosphate solubilization. Polymerase Chain Reaction (PCR) testing revealed that strain FJ3 has the potential to produce lipopeptides such as fengycin, surfactin, mycosubtilin, and pilpastatin. Through in vitro antagonism testing it was demonstrated that strain FJ3 is able to inhibit Fusarium oxysporum by 52% compared to the untreated control and was antagonistic against Aspergillus flavus, Aspergillus niger, and Rhizopus oryzae using a dual method. The minimum inhibitory concentration of Bacillus crude extract resulted in a 92%, 90%, 81.5%, and 56% growth inhibition of Fusarium oxysporum, A. niger, A. flavus, and Rhizopus oryzae, respectively. In FT-IR and GC-MS analysis of crude LPs extract, the transmission and mass spectrum confirmed the existence of aforesaid lipopeptides containing β-fatty acids with chain lengths ranging from C14 to C21 in which the majority were saturated fatty acids. Greenhouse experimentation revealed that Bacillus strain FJ3 and its metabolites significantly diminished the disease incidence with an average reduction of 31.56%. In sterilized soil, FJ3 and its metabolites caused 24.01% and 10.46% growth promotion, respectively, in chickpea. The results demonstrated that Bacillus strain FJ3 has broad-spectrum antifungal and plant growth-promoting applications and could be a promising candidate for development into a commercialized biobased product for use in sustainable agriculture practice.
Real-time dense small object detection algorithm based on multi-modal tea shoots
Authors: Shuai Luyu , Chen Ziao , Li Zhiyong , Li Hongdan , Zhang Boda , Wang Yuchao , Mu Jiong
Published: July 2023

Introduction

The difficulties in tea shoot recognition are that the recognition is affected by lighting conditions, it is challenging to segment images with similar backgrounds to the shoot color, and the occlusion and overlap between leaves.

Methods

To solve the problem of low accuracy of dense small object detection of tea shoots, this paper proposes a real-time dense small object detection algorithm based on multimodal optimization. First, RGB, depth, and infrared images are collected form a multimodal image set, and a complete shoot object labeling is performed. Then, the YOLOv5 model is improved and applied to dense and tiny tea shoot detection. Secondly, based on the improved YOLOv5 model, this paper designs two data layer-based multimodal image fusion methods and a feature layerbased multimodal image fusion method; meanwhile, a cross-modal fusion module (FFA) based on frequency domain and attention mechanisms is designed for the feature layer fusion method to adaptively align and focus critical regions in intra- and inter-modal channel and frequency domain dimensions. Finally, an objective-based scale matching method is developed to further improve the detection performance of small dense objects in natural environments with the assistance of transfer learning techniques.

Results and discussion

The experimental results indicate that the improved YOLOv5 model increases the mAP50 value by 1.7% compared to the benchmark model with fewer parameters and less computational effort. Compared with the single modality, the multimodal image fusion method increases the mAP50 value in all cases, with the method introducing the FFA module obtaining the highest mAP50 value of 0.827. After the pre-training strategy is used after scale matching, the mAP values can be improved by 1% and 1.4% on the two datasets. The research idea of multimodal optimization in this paper can provide a basis and technical support for dense small object detection.
Metacognitive effects of attitudinal (in)congruence on social media: relating processing fluency, subjective knowledge, and political participation
Authors: Frauhammer Luna T. , Neubaum German
Published: July 2023

Introduction

Encountering political disagreements in our daily lives can discourage us from participating in democratic processes. To date, research has mainly focused on social motives or attitudinal mechanisms to explain this phenomenon. In the present study, we adopt a different approach and highlight metacognitive effects of attitudinal (in)congruence on processing fluency (i.e., perceived ease of processing) and subjective knowledge as well as their relationship with behavioral outcomes such as the intention to politically participate.

Methods

In a pre-registered online experiment (N = 1,258), participants saw a political social media post with six opinionated user-generated comments. These comments either all matched (congruent condition) or contradicted (incongruent condition) participants’ personal opinions. Processing fluency, issue specific subjective knowledge, and intention to politically participate were then measured using established self-report scales.

Results

In line with our hypotheses, the congruent stimuli evoked a higher feeling of processing fluency than the incongruent ones (d = 0.21). Furthermore, participants in the congruent condition indicated a higher intention to politically participate (d = 0.23) and rated their own knowledge on the topic as higher (d = 0.22) than participants in the incongruent condition—even though the factual knowledge gain should be equal in both conditions. Finally, we observed positive relationships between processing fluency and subjective issue knowledge (β = 0.11) as well as between subjective issue knowledge and issue-specific political participation (β = 0.43).

Discussion

Our findings highlight the importance of considering metacognitive constructs such as subjective knowledge to explain political behaviors and suggest that attitudinal congruence influences the way we perceive our own knowledge and information processing.