bluuebunny/crossref_metadata_2025 huggingface dataset:
Eruptive Oral Mucoceles in a Neonate
Authors: Niaz Ghassan , De Moll Ellen H , Zinns Lauren , Tassavor Bryan , Phelps Robert G
Published: September 2020

Mucoceles are one of the most common benign mucosal growth in the oral cavity. They may be under-recognized in children. Mucoceles infrequently present in groups. We present an unusual case of eruptive superficial mucoceles in a 6-day old male that served as a diagnostic dilemma.
Blistering Rash over Broken Ribs
Authors: Graham Kathleen R , Rohr Bethany R , Marks Victor J
Published: September 2020

Fracture blisters are painless fluid-filled bullae most commonly located over fractures of the distal tibia and humerus. They are diagnosed clinically. Invasive procedures and treatments increase the risk of wound infection and should be avoided. While there is no consensus on management, evidence supports leaving the blisters intact and treating erosions with topical barrier ointments or topical antibiotics. We present a rare case of a 55-year-old man with fracture blisters located superficial to trauma-induced rib fractures that were successfully treated with topical mupirocin.
A Postherpetic Isotopic Response Presenting as a Granuloma Annulare-Like Inflammatory Reaction
Authors: Heibel Haley D , Cockerell Clay J
Published: September 2020

Isotopic response refers to the occurrence of a new, unrelated cutaneous disease occurring at the same location of a previous healed disease.  The etiology of isotopic responses is still not completely understood.  Theories have included that viral particles may lead to the development of the second disease, the destruction of nerve fibers by herpes zoster may lead to an indirect influence on the immune system, an alteration of microcirculation from inflammation that causes future insults to localize to the same site, and an exaggerated and atypical hypersensitivity reaction to tissue antigens, viral antigens, or immune complex deposition.  A wide variety of disease processes have been reported as the second disease in an isotopic response.Here, we discuss a case of an isotopic response following herpes zoster in which the second disease involved a granuloma annulare (GA)-like inflammatory reaction that resolved and recurred.  These findings support the theory that the skin affected by herpes zoster is affected in a way that makes it a focus for the manifestation of further skin diseases.
Falling in Hair Love Comes Naturally
Authors: Oduguwa Emmanuella , Tahseen Danyal
Published: September 2020

Abstract not available.
Management and Referral Patterns in Pediatric Atopic Dermatitis: A Survey of Pediatric Healthcare Professionals
Authors: Bernett Courtney Nicole , Hignett Emma , Kwong Pearl
Published: September 2020

Background: The incidence of pediatric atopic dermatitis (AD) has continued to increase worldwide and pediatric healthcare providers (PHPs) are typically the initial healthcare provider tasked with management of this disease. The consequences of inadequately managed AD and misdiagnosed food allergies are devastating for patients and their families, and the financial burden associated with these scenarios can be overwhelming.
Objective: To assess the management and referral patterns of pediatric AD patients by PHPs in the Jacksonville, Florida (FL) area.
Methods: An online electronic survey was distributed to 70 PHPs using Survey Monkey©.  Data was collected over a 6-week period. The survey yielded a sample size of 28.
Results: Most participants were physicians (92.8%), with an average of 21.75 years in practice. Just over half (53%) of PHPs were aware of the American Academy of Dermatology (AAD) Guidelines of care for the management of AD. Dermatologists were the initial referral choice for AD management in 2/3, while 1/3 indicated preference for an allergist. Diet alteration was used by 14.3% as an initial AD management step and 35.7% tried elimination diets prior to referral to an allergist. Referral to specialists were low with 75% PHPs referring <25 % of their AD patients to dermatology.
Conclusion: With the number of outpatient AD visits increasing amongst PHPs, knowledge of management guidelines, in-depth understanding of appropriate use and limitations of elimination diets and food allergen testing, and referral to specialists suitable for management of this cutaneous disorder are imperative, but found to be highly variable.
The Impact of Skin Disease on Quality of Life in Rural Communities of Ghana
Authors: Laggis Caroline W , Secrest Aaron M , Agyei Martin , Simister Sam , Davis Andrea N , Dickerson Ty , Rhoads Jamie LW
Published: September 2020

Background: Skin disease is the fourth-leading cause of non-fatal disability worldwide. Granular data are limited on the skin disease burden in underserved populations.
Objectives: To describe the skin disease burden among adults in rural Ghana.
Methods: In this observational study, 230 adults in rural Ghana were surveyed using the Dermatology Life Quality Index (DLQI). For those reporting a skin problem in the previous week (n=117) and who had skin examination performed by a dermatology resident and/or local dermatologist (n=98), prevalences and univariate comparisons were calculated.
Results: 51% (117/230) of participants reported a skin problem in the previous week with 36% (42/117) reporting at least a moderate impact on quality of life (QoL). Factors associated with a higher QoL impact included female gender (p=0.01) and living further from the city center (p=0.02). The most common dermatologic diagnoses for those with skin examination performed included acne, bacterial infection, and pruritus. QoL was most impacted (highest average DLQI scores) for those with scabies. Diagnoses were categorized by the level of treatment or medical expertise that would be required had the participant presented to a clinic. 80% (78/98) of diagnoses rendered were potentially manageable with counseling or topical medication.
Limitations: The studied cohort was obtained via convenience sampling. The DLQI has not yet been validated in this population.
Conclusions: Much of the QoL impact from skin disease among adults in rural Ghana resulted from diagnoses that are manageable with counseling and topical medication. Better access to basic health care and more dermatologic education among community health providers would address much of the skin disease burden in these communities. Future studies should examine best practices for addressing unmet dermatologic needs of this and other comparable populations in underserved communities.
Maskne: Exacerbation or Eruption of Acne During the COVID-19 Pandemic
Authors: Gomolin Tamar A , Cline Abigail , Russo Marian
Published: September 2020

Although the COVID-19 outbreak has decreased dermatology outpatient clinic visits, acne remains the most common condition among patients requesting an appointment. The widespread use of face masks may be a contributing factor to acne mechanica and folliculitis mechanica, where stopping the mechanical insult is essential to treatment. However, COVID-19 poses a unique challenge as mask wearing is crucial to limiting viral exposure. Although reported cases of mask-associated facial dermatoses are largely documented in healthcare workers, the general population is being affected by “maskne”. Pathogenesis and treatment options are discussed and the importance of counseling patients on proper skin hygiene is highlighted. As mask use increases, dermatologists should anticipate this trend in acne flare-ups.
An Oral, Selective Tyrosine Kinase 2 Inhibitor, BMS-986165, Reduced Absolute Psoriasis Area and Severity Index in a Phase 2 Trial in Psoriasis
Authors: Strober Bruce , Gottlieb Alice , Thaçi Diamant , Puig Luis , Colombo Matthew J , Kundu Sundeep , Kisa Renata , Banerjee Subhashis
Published: September 2020

Abstract not available.
BMS-986165, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor: Evaluation of Changes in Laboratory Parameters in Response to Treatment in a Phase 2 Trial in Psoriasis Patients
Authors: Gordon Kenneth , Papp Kim , Gooderham Melinda , Morita Akimichi , Foley Peter , Thaçi Diamant , Kundu Sundeep , Kisa Renata , Wei Lan , Banergee Subhashis
Published: September 2020

Abstract not available.
Tapinarof Cream for the Treatment of Plaque Psoriasis: Efficacy and Safety by Baseline Disease Characteristics and Skin Type in a Phase 2b Randomized Study
Authors: Lebwohl Mark , Del Rosso James Q , Hong Chih-Ho , Tailman Anna M , Kircik Leon
Published: September 2020

Abstract not available.
Long-Term Proactive Management of Psoriasis Vulgaris with Fixed-Dose Combination of Calcipotriene 0.005% and Betamethasone Dipropionate 0.064% Foam: Results from a Phase III Randomized Controlled Trial
Authors: Lebwohl Mark , Lacour Jean-Philippe , Liljedahl Monika , Lynde Charles , Mørch Marie H , Thaçi Diamant , Warren Richard B
Published: September 2020

Abstract not available.
Real World Patient Perceptions of the use of Calcipotriene Foam 0.005% in the Treatment of Plaque Psoriasis
Authors: Kerdel Francisco , Don Christina , Block Renata , Lewis Caitlin , Schreiber Rhonda
Published: September 2020

Abstract not available.
A Multicenter, Open Label, Phase 1 Study of the Safety, Tolerability, Systemic Exposure, Pharmacodynamics, and Treatment Effect of Calcipotriene Foam, 0.005% in Pediatric Subjects (Ages 2 to 11 Years) with Plaque Psoriasis
Authors: Herbert Adelaide A , Glaab Debbie , Schreiber Rhonda
Published: September 2020

Abstract not available.
Phase 3 Trial Demonstrates that MC2-01 Cream has Improved Treatment Efficacy Compared to Calcipotriene Plus Betamethasone Dipropionate Topical Suspension in Patients with Mild to Moderate Psoriasis Vulgaris
Authors: Selmer Johan , Vestbjerg Birgitte , Præstegaard Morten , Gold Linda Stein
Published: September 2020

Abstract not available.
Long-Term Management of Moderate-to-Severe Plaque Psoriasis: Maintenance of Treatment Success Following Cessation of Fixed Combination Halobetasol Propionate 0.01% and Tazarotene 0.045% (HP/TAZ) Lotion in Patients with Baseline Body Surface Area of 6 -12%
Authors: Gold Linda Stein , Weiss Jonathan S , Green Lawrence , Kircik Leon , Miller Lauren , Jacobson Abby , Harris Susan
Published: September 2020

Abstract not available.
Safety and Tolerability of Fixed Combination Halobetasol Propionate 0.01% and Tazarotene 0.045% (HP/TAZ) Lotion in Patients With Moderate-to-Severe Plaque Psoriasis: Results From a 1-Year, Open-Label Study
Authors: Lebwohl Mark G , Sugarman Jeffrey , Pariser David M , Bagel Jerry , Trickett Cynthia , Jacobson Abby , Israel Robert
Published: September 2020

Abstract not available.
Early and Maintained Response Levels in Psoriasis Patients Treated with Tildrakizumab
Authors: Papp Kim A , Yeung Jensen , Shear Neil , Albrecht Lorne , Lynde Charles , Zhang Jingchuan , Zhao Yang , Parno Jeff , Mendelsohn Alan M , Gooderham Melinda
Published: September 2020

Abstract not available.
Tildrakizumab Efficacy by Metabolic Syndrome Status in Psoriasis: Post Hoc Analysis of 3-Year Data from the Phase 3 Resurface 1 And Resurface 2 Studies
Authors: Lebwohl Mark G , Mehta Nehal N , Gottlieb Alice B , Mendelsohn Alan M
Published: September 2020

Abstract not available.
Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Phase 2b Study to Demonstrate the Safety and Efficacy of Tildrakizumab, a High-Affinity Anti–Interleukin-23P19 Monoclonal Antibody, in Patients with Active Psoriatic Arthritis
Authors: Mease Philip J , Chohan Saima , Garcia Fructuoso Ferran J , Gottlieb Alice B , Chou Richard C , Mendelsohn Alan M , Luggen Michael E
Published: September 2020

Abstract not available.
Dupilumab Decreases Blood Biomarkers in Adolescents With Moderate-to-Severe Atopic Dermatitis: Data From a Phase 3 Trial (LIBERTY AD ADOL)
Authors: Simpson Eric L , Fujita Hiroyuki , Arima Kazuhiko , Hamilton Jennifer , Lu Yufang , Rossi Ana B , Bansal Ashish
Published: September 2020

Abstract not available.
Dupilumab in Adolescents With Moderate-to-Severe Atopic Dermatitis and a History of Allergic Rhinitis: Subgroup Analysis From a Phase 3 Trial (LIBERTY AD ADOL)
Authors: Sher Lawrence , Soong Weily , Prescilla Randy , Chen Zhen , Bansal Ashish
Published: September 2020

Abstract not available.
Integrated Safety and Efficacy Analysis of FMX103 1.5% Topical Minocycline Foam for the Treatment of Moderate-to-Severe Papulopustular Rosacea: Results From Two Phase 3 Studies
Authors: Del Rosso James Q , Gold Linda Stein , Kircik Leon , Bhatia Neal D , Sadick Neil , Zirwas Matthew , Lain Edward , Stuart Iain
Published: September 2020

Abstract not available.
Real World Patient Perceptions of the use of Tazarotene 0.1% Foam in the Treatment of Acne Vulgaris
Authors: Del Rosso James Q , Hartman Corey L , Lewis Caitlin , Schreiber Rhonda
Published: September 2020

Abstract not available.
Efficacy and Safety of a Novel Tazarotene 0.045% Lotion in Females and Males With Moderate-to-Severe Acne
Authors: Baldwin Hilary E , Green Lawrence , Kircik Leon , Caronia Ashlie M , Guenin Eric
Published: September 2020

Abstract not available.
Phase 3 Trial Demonstrates Superior Patient Treatment Convenience of MC2-01 Calcipotriene Plus Betamethasone Dipropionate Cream Compared to Current Topical Suspension
Authors: Præstegaard Morten , Vestbjerg Birgitte , Selmer Johan , Holm-Larsen Tove
Published: September 2020

Abstract not available.
Efficacy of ALA–PDT in the Treatment of Actinic Keratoses on the Upper Extremities: A Post Hoc Analysis of a Phase 3, Randomized, Vehicle-Controlled Trial
Authors: Berman Brian , Bhatia Neal , Piacquadio Daniel , Houlihan Anna , Siegel Daniel
Published: September 2020

Abstract not available.
Efficacy of Tapinarof Cream by Body Region in Subjects With Plaque Psoriasis in a Phase 2b Randomized Controlled Study
Authors: Bissonnette Robert , Gold Linda Stein , Kircik Leon , Tyring Stephen , Tailman Anna , Armstrong April
Published: September 2020

Abstract not available.
Efficacy of translamina terminalis ventriculostomy tube in prevention of chronic hydrocephalus after aneurysmal subarachnoid hemorrhage
Authors: Elsharkawy Ahmed Abdelaziz , Abdelhameed Essam Ahmed
Published: September 2020

Background:

Chronic shunt-dependent hydrocephalus is still a common complication after aneurysmal SAH (aSAH) and is associated with increased morbidity. Pathology of chronic shunt-dependent hydrocephalus after aSAH is complex and multifactorial which makes its prevention challenging. We thought to evaluate whether external ventricular drainage (EVD) through fenestrated lamina terminalis would decrease the rate of chronic shunt-dependent hydrocephalus after aSAH.

Methods:

A retrospective analysis of 68 consecutive patients with aSAH who underwent microsurgical clipping of the ruptured aneurysm. Patients were divided into two groups: Group A included patients with lamina terminalis fenestration without insertion of ventriculostomy tube and Group B included patients with EVD through fenestrated lamina terminalis. Demographic, clinical, radiological, and outcome variables were compared between groups.

Results:

Group A comprised 29 patients with mean age of 47.8 years and Group B comprised 39 patients with mean age of 46.6 years. Group B patients had statistically significant (P < 0.05) lower incidence of chronic shunt- dependent hydrocephalus than Group A patients (30.8% vs. 55.2%, respectively).

Conclusion:

EVD through fenestrated lamina terminalis is safe and may be effective in decreasing the incidence of chronic shunt-dependent hydrocephalus after aSAH.
Rapid high-fidelity contour shaping of titanium mesh implants for cranioplasty defects using patient-specific molds created with low-cost 3D printing: A case series
Authors: Kinsman Michael , Aljuboori Zaid , Ball Tyler , Nauta Haring , Boakye Maxwell
Published: September 2020

Background:

Cranioplasty is a neurosurgical procedure to repair skull defects. Sometimes, the patients’ bone flap cannot be used for various reasons. Alternatives include a custom polyether ether ketone (PEEK) implant or titanium mesh; both incur an additional cost. We present a technique that uses a 3D printer to create a patient- specific 3D model used to mold a titanium mesh preoperatively.

Case Description:

We included three patients whose bone flap could not be used. We collected the patients’ demographics, cost, and time data for implants and the 3D printer. The patients’ computed tomography DICOM images were used for 3D reconstruction of the cranial defect. A 3D printer (Flashforge, CA) was used to print a custom mold of the defect, which was used to shape the titanium mesh. All patients had excellent cosmetic results with no complications. The time required to print a 3D model was ~ 6 h and 45 min for preoperative shaping of the titanium implant. The intraoperative molding (IOM) of a titanium mesh needed an average of 60 min additional operative room time which incurred $4000. The average cost for PEEK and flat titanium mesh is $12,600 and $6750. Our method resulted in $4000 and $5500 cost reduction in comparison to flat mesh with IOM and PEEK implant.

Conclusion:

3D printing technology can create a custom model to shape a titanium mesh preoperatively for cranioplasty. It can result in excellent cosmetic results and significant cost reduction in comparison to other cranioplasty options.
Determinants of discharge against medical advice from a rural neurosurgical service in a developing country: A prospective observational study
Authors: Oyemolade Toyin Ayofe , Adeleye Amos Olufemi , Ogunyileka Oluwakemi C. , Arogundade Folawemimo M. , Olusola Ayodele J. , Aribisala Oluwadamilola O.
Published: September 2020

Background:

In low-resource regions of the world, discharge against medical advice (DAMA) is one empiric contributory factor to poor in-hospital outcome that is not often mentioned. This study aims to investigate the determinants of DAMA from a rural neurosurgical service in a developing country.

Methods:

This was a prospective observational study of all patients who discharged against medical advice in our service between November 2018 and October 2019.

Results:

There were 88 patients, 67 (76.1%) males, in the study, (M:F = 3.2:1), representing 17.4% of our patient population in the study period. The peak incidence was in the 20–29 years age group which accounted for 37.5% of the cases. About 55% of the patients presented directly to our center; 31.8% were referred from other hospitals, while 3.4% came from traditional caregivers and 1.1% from religious homes. Head injury was the most common indication for presentation (76.1% of the cases). The duration of hospital stay ranged from 2 h to 14 days. Majority of the patients (87.5%) left the hospital within 8 h of presentation. The reason for DAMA was financial constraints in 50% of cases, inadequate health literacy in 20.5%, financial constraints and poor health literacy together in 12.5%, religious misgivings in 4.5%, and traditional belief in 2.3%. Neurotrauma was predictive of early DAMA (P= 0.001).

Conclusion:

The rate of DAMA was high in our study. Financial constraints with other socioeconomic limitations were the most common causes of DAMA in our environment.
Peran Dimensi-Dimensi Entrepreneurial Marketing dalam Mendorong Kesuksesan Bisnis UMKM di Industri Ekonomi Kreatif
Authors: Setiyaningrum Ari , Ramawati Yussi
Published: September 2020

This study aims to analyze the influence of entrepreneurial marketing dimensions, including proactiveness, opportunity-focused, risk-taking orientation, innovation-oriented, customer intensity, resource leveraging, and value creation of Small and Medium Enterprises (SMEs) business success in the creative economy industry. The study also examined the moderating role of company age on the entrepreneurial marketing dimension's influence on SME's business success. The study used survey methods by distributing questionnaires to 265 SME business owners in North Kalimantan. The sampling method uses nonprobability sampling with a convenience sampling technique. Data were analyzed using multiple linear regression analyses and moderated tests using the macro process of SPSS Hayes. The results of this study indicated that in the context of SMEs in the creative industry, customer intensity and value creation play a critical role in business success. Meanwhile, proactiveness, opportunity-focused, risk-taking orientation, innovation-oriented, and resource leveraging found no impact on SMEs' business success. The research also proves that the company's age moderated the impact of customer intensity on SME's success but does not moderate the influence of value creation to SME's business success.
Konsep Kesatuan Usaha : Pendekatan Socioemotional Wealth dan Family Embeddedness
Authors: Kristianti Ika , Charita Nindya Permata , Prastyo Bagus Dwi
Published: September 2020

The purpose of this study is to analyze and make conclusions about the concept of business unity that will be associated with socioemotional wealth and family embeddedness. This study will portray SMEs from the concept of business entity. This study uses Social-Emotional Wealth (SEW) and Family Embeddedness (FE). There are five dimensions in SEW and three dimensions in FE. This research uses qualitative research with the object of research of several food and beverage and batik UKM in Salatiga and Surakarta. The selection of research objects is based on the length of the business and the family's business management. The technique used in this study was an interview with six people as key informants. The results showed that the majority of SMEs in this study had applied the concept of a business entity. The social-emotional wealth approach has a bigger role than the kinship family approach because external factors trigger the development of SMEs in maintaining their business continuity more and internal factors of family members actually reduce company performance because they are prone to conflict and thus costs. that happened was bigger.
Telegram como herramienta para periodistas: Percepción y uso
Authors: Sánchez Gonzales Hada M. , Martos Moreno Javier
Published: September 2020

La búsqueda de modelos de negocio alternativos y el auge de las nuevas tecnologías han propiciado una transformación en las rutinas de los periodistas y en el rol de las audiencias. Este debate se ha acrecentado a raíz del protagonismo de plataformas como las redes sociales o las aplicaciones de mensajería instantánea. El presente estudio analiza la instrumentalización de Telegram en las rutinas periodísticas debido a la utilidad, seguridad y privacidad que ofrece la plataforma. Gracias a estas cualidades técnicas que presenta, Telegram ha irrumpido en las prácticas rutinarias de los periodistas, especialmente, como fuente de información personalizada y como canal de distribución de noticias. La percepción de los profesionales y estudiantes de comunicación es positiva, en relación al consumo de información a través de las breaking news y titulares relevantes por la sencillez y originalidad de uso de la aplicación. Sin embargo, pese a su incursión en la actividad periodística, su escasa implantación social todavía representa un importante escollo para su desarrollo a nivel de la población.
Los derechos digitales durante la pandemia COVID-19 en Argentina, Brasil y México
Authors: Bizberge Ana , Segura María Soledad
Published: September 2020

Este artículo estudia estrategias, actores, condiciones y debates sobre los derechos digitales durante la pandemia de COVID-19 en México, Argentina y Brasil. El abordaje teórico es el de la comunicación como un derecho humano fundamental y las políticas de la comunicación. El enfoque metodológico es un análisis comparativo teórico-normativo y socio-político. Los ejes de debate giraron en torno a los derechos digitales de acceso, privacidad y libertad de expresión. Las políticas estatales variaron en función de la orientación política de sus gobernantes, el enfoque de políticas públicas pre-existentes y las adoptadas frente a la COVID-19, y las relaciones de fuerza existentes entre los actores involucrados en cada país. Las empresas desarrollaron estrategias regresivas de las que, en ciertos casos, tuvieron que dar marcha atrás, y algunas progresivas pero excepcionales; la sociedad civil y los organismos internacionales impulsaron soluciones progresivas y de largo plazo.
Handling with online comments: a longitudinal approach in most accessed news sites in Portugal, Spain and Brazil
Authors: Fonseca Ribeiro Fábio
Published: September 2020

Online comments have been a widespread feature in news media. Although audiences recognize it widely, doubts remain about the purpose of these interactive spaces. Arguably, understanding how media value online comments defines a way which public debates are socially perceived. Based on The Reuters Institute Digital News Report 2019, this article analysed current media policies towards online commenting in most accessed news websites in Portugal, Spain and Brazil. Following both a quantitative-qualitative methodology, a direct observation and a textual/visual analysis, this article highlights levels of similarity in these policies: comment sections are still predominantly available (31 from 45); comments are typically placed at the bottom of the page; the interactive options identical (share, like, dislike, report). As the overall cases exclude comment moderation, few media (in Portugal, but mostly in Spain) propose alternative models based on the community: voting, comment ranking and autonomous discussion forums.
La caída de los ingresos y la audiencia de los medios públicos europeos (2010-2018)
Authors: Gesto-Louro Alejandro , Campos-Freire Francisco
Published: September 2020

Este artículo analiza la evolución negativa de los ingresos de los medios públicos europeos y de la audiencia de sus canales de televisión entre los años 2010 y 2018. Los datos financieros y de share –obtenidos, principalmente, del OAE– se han contrastado, a nivel cuantitativo, con indicadores económicos homogeneizadores como la PPA; y se han agrupado en torno a los modelos propuestos por Hallin y Mancini (2004, 2008, 2013). A nivel cualitativo, se han realizado entrevistas a dos académicos –Tiziano Bonini (Universidad de Siena) y Marko Ala-Fossi (Universidad de Tampere)– y a Mika Ojamies, director de relaciones internacionales de la YLE. A pesar de confirmarse esa tendencia negativa, no se establece una correlación entre el descenso de los ingresos y el de la audiencia. En cualquier caso, la Academia evidencia la necesidad de desarrollar nuevos sistemas de financiación que garanticen la estabilidad presupuestaria de los medios públicos.
Editorial
Authors: Zeta de Pozo Rosa
Published: September 2020

Este segundo número del año de la Revista de Comunicación, se publica en un contexto social en el que globalmente estamos conviviendo con una pandemia, que está afectando no sólo el ámbito sanitario y social, sino también el político, económico, educativo, y por supuesto el de la comunicación.
La comunicación ha seguido su curso en un inusual entorno de confinamiento y vive una aceleración del proceso de transformación digital que ya se venía desarrollando. La data, aunque parcial, nos muestra un primer semestre con resultados diversos. Observamos que la crisis del coronavirus ha aumentado sustancialmente el consumo de las noticias en los medios digitales y en las redes sociales, sin embargo, la confianza en los medios es dos veces mayor que para las redes sociales; se reconoce el valor de los medios de comunicación, pero la recesión cíclica en la economía está perjudicando a todos los editores (Reuters, 2020). Otros sectores, en cambio, como OTT, servicios de streaming, video games, e-sport, data consumption, se han fortalecido en tiempos de pandemia y han logrado resultados beneficiosos, al tener a su audiencia cautiva. El entretenimiento tiene la casa como escenario permanente.
Alzola Cerero, P. (2020). El cine de Terrence Malick. La esperanza de llegar a casa
Authors: Noguera Tajadura María
Published: September 2020

Terrence Malick puede ser considerado como uno de los directores de cine más relevantes del panorama fílmico actual. Se trata de un cineasta singular, con un fuerte sello autoral, guionista de sus propias películas, curtido en la mayoría de los géneros, premiado en los grandes festivales y, cosa rara en los tiempos que corren, profundamente reservado en cuanto su vida privada se refiere. Las apariciones públicas de Malick durante los estrenos y la promoción de sus filmes son prácticamente nulas: ni concede entrevistas ni acude a los pases de prensa, por lo que tiene fama de director huidizo.
Parvovirus B19 infection in HIV-infected patients
Authors: Petrenko A. A. , Dudina G. A. , Kremneva N. V. , Pivnik A. V.
Published: September 2020

Here we provide a review of the literature and a description of our own clinical case. The patient was a 32-year-old woman who had been infected with HIV for 6 years without antiretroviral therapy. The test results showed CD4 87 cells/l, viral load 3750 copies/ml. Normochromic normocytic anemia and reticulocytopenia developed soon. In the myelogram, all erythroblasts were 0.5%. The viral load of parvovirus B19 DNA according to PCR was more than 9 million IU/ml. Pure red cell aplasia associated with parvovirus B19 was diagnosed. We started antiretroviral therapy with efavirenz, lamevudine and tenofovir. In addition to blood transfusions, we administered intravenous donor immunoglobulin with a dose increase from 5000 mg to 20 000 mg per day. After discontinuing of intravenous immunoglobulins, the laboratory test results were stable over the next 5 months: hemoglobin was more than 115 g/L, reticulocytes more than 3%, in the myelogram all erythroblasts were 21%. However, the elimination of parvovirus B19 wasnt achieved. The maximum decrease in viral load for parvovirus B19 was down to 720 IU/ml. A typical feature of the case was the lack of pure red cell aplasia of the bone marrow with the existing viral load of parvovirus B19. HIV infection progressed: 44 cells/l, viral load not determined. The case ended lethally.
Immunosupressive therapy of aplastic anemia patients: successes and failures (single center experiment 2007–2016)
Authors: Mikhaylova E. A. , Fidarova Z. T. , Abramova A. V. , Luchkin A. V. , Troitskaya V. V. , Dvirnyk V. N. , Galtseva I. V. , Kliasova G. A. , Kovrigina A. M. , Kulikov S. M. , Chabaeva Yu. А. , Parovichnikova E. N. , Savchenko V. G. , Obukhova T. N.
Published: September 2020

Treatment programs for patients with acquired aplastic anemia include two main therapeutic options: allogeneic bone marrow transplantation and combined immunosuppressive therapy (IST). However, combined IST remains the method of choice for most adult AA patients. This study included 120 AA patients who received IST at the National Research Center for Hematology in 20072016. The analysis was applied to 120 patients. Median age was 25 (1765) years, M/F: 66/54, SAA/NSAA: 66%/34%. Effectiveness of IST was carried out in 120 patients with AA. This group did not include 8 SAA patients who died during the first 3 months from the start of treatment from severe infectious complications (early deaths 6.2%) and 2 AA patients who dropped out of surveillance. The observation time was 55 (6120) months. Paroxysmal nocturnal hemoglobinuria (PNH clone) was detected in 67% of AA patients. The median PNH clone size (granulocytes) was 2.5 (0.0199.5)%. The treatment was according to the classical protocol of combined IST: horse antithymocytic globulin and cyclosporin A. Most of patients (87%) responded to combined immunosuppressive therapy. To achieve a positive response, it was sufficient to conduct one course of ATG to 64% of patients, two courses of ATG 24% of patients and 2% of patients responded only after the third course of ATG. A positive response after the first course was obtained in 64% of patients included in the analysis. Most of the responding patients (93%) achieve a positive response after 36 months from the start of treatment. Therefore, the 3rd6th months after the first course of ATG in the absence of an answer to the first line of therapy can be considered the optimal time for the second course of ATG. This tactic allows to get an answer in another 58% of patients who did not respond to the first course of ATG. The probability of an overall 10-year survival rate was 90% (95% confidence interval 83.696.2).
Multipotent mesenchymal stromal cells application for acute graft versus host disease treatment
Authors: Kuzmina L. A. , Petinati N. A. , Vasilieva V. A. , Dovydenko M. V. , Drokov M. Yu. , Davydova Yu. O. , Kapranov N. M. , Sats N. V. , Chabaeva Yu. A. , Kulikov S. M. , Gaponova T. V. , Drize N. I. , Parovichnikova E. N. , Savchenko V. G.
Published: September 2020

Aim.Analysis of the effectiveness of the MSCs aministration as the second- or third-line therapy of acute GVHD (aGVHD) resistant to glucocorticosteroid treatment.
Materials and methods.The study included 35 patients who received MSCs obtained from the bone marrow of healthy donors as a treatment of steroid-resistant aGVHD. The clinical parameters of patients, MSCs cultural characteristics, the MSC expression profile for various genes including those involved in immunomodulation, expression of cells surface markers, the source of MSCs, as well as the frequency and number of MSC administrations were analyzed.
Results.Response to therapy was achieved in 74% of cases, a complete response was reached in 13 (37%) patients, partial response/clinical improvement was demonstrated in 13 (37%). This treatment was ineffective in 9 patients. The prediction of a group of patients with good response to MSC therapy turned to be impossible. The differences between the effective and ineffective for the GVHD treatment MSCs samples were found. The effective ones were characterized with a decreased total MSCs production and an increase in the main histocompatibility complex and PDL-1 antigens expression.
Conclusion.These data allow to select optimal samples for aGVHD treatment that can improve clinical results. aGVHD treatment with MSCs has shown efficacy comparable to other treatment approaches. Given the low percentage of complications and the absence of significant adverse effects, MSC therapy seems to be one of the optimal approaches to the treatment of resistant forms of GVHD.
Fecal microbiota transplantation for graft-versus-host disease in children and adults: methods, clinical effects, safety
Authors: Goloshchapov O. V. , Chukhlovin A. B. , Bakin E. A. , Stanevich O. V. , Klementeva R. V. , Shcherbakov A. A. , Shvetsov A. N. , Suvorova M. A. , Bondarenko S. N. , Kucher M. A. , Kulagin A. D. , Zubarovskaya L. S. , Moiseev I. S.
Published: September 2020

Aim.Was to evaluate clinical efficacy, adverse events and changes in the gut microbiome after fecal microbiota transplantation (FMT) in patients with gastrointestinal (GI) form of graft-versus-host disease (GVHD).
Materials and methods.The prospective single-center study in R.M. Gorbacheva institute included 27 patients with GI GVHD after allogeneic stem cell transplantation. 19 patients received FMT, 8 patients received placebo. Clinical scales for GI autoimmune diseases were used to evaluate response. Microbiome alterations were assessed with multiplex PCR.
Results.After FMT higher overall bacterial mass (р=0.00088), higher bacterial numbers ofBifidobacteriumspp. (р=0.021),Escherichia coli(р=0.049) andBacteroides fragilisgr. (р=0.000043) compared to placebo group. Also higher bacterial mass was observed in patients with clinical response (р=0.0057). The bacterial mass after procedure in non-responders was compared to the placebo group (р=0.31). Partial response of GVHD was achieved faster in the FMT group compared to placebo (median 4 days vs 48 days,p=0.014). Complete response was observed in 8 (42%), 14 (74%) and 16 (84%) at 30, 60 and 90 days respectively, while in the placebo group only 0%, 1 (13%) and 4 (50%) achieved complete response at the same time points. The incidence and severity of adverse events was comparable between FMT and the placebo group.
Conclusion.FMT in patients with refractory GI GVHD was associated with favorable clinical outcomes and recovery in certain marker bacterial populations. Multiplex PCR can be used to assess an engraftment of a donor microbiota. FMT in GI GVHD was not associated with life-threatening adverse events, but further studies are required to validate clinical efficacy.
Morphological and immunohistochemical predictors of renal response to therapy patients with myeloma cast nephropathy and dialysis-dependent acute kidney injury
Authors: Rekhtina I. G. , Kazarina E. V. , Stolyarevich E. S. , Kovrigina A. M. , Dvirnyk V. N. , Kulikov S. M. , Mendeleeva L. P.
Published: September 2020

Aim.Reveal morphological and immunohistochemical predictors of reversibility of dialysis-dependent acute kidney injury (AKI) in patients with myeloma cast nephropathy (MCN) based on the study of kidney biopsy.
Materials and methods.Renal pathological findings were studied in 36 patients with MCN and dialysis-dependent stage 3 AKI (AKIN, 2012). The study of biopsy samples was performed by a semi-quantitative and quantitative analysis using computer morphometry. The expression of E-cadherin, vimentin and-smooth muscle actin was determined immunohistochemically in the tubular cells and interstitium. Induction therapy for 26 patients was carried out to bortezomib-based programs; in 10 patients other schemes were used. A comparative analysis of morphological changes in nephrobiopathy depending on the renal response was performed in patients with achieved hematologic remission.
Results.Improved renal function was observed only in patients with hematologic response to therapy. There were no differences in the number of sclerotic glomeruli, protein casts, the area of inflammatory interstitial infiltration, and the degree of acute tubular damage in patients with and without renal response. In patients with renal response compared with patients without improving renal function, the area of interstitial fibrosis was less (24.9% and 45.9%, respectively;p=0.001), and the area of E-cadherin expression was larger (15.9% and 7.1%, respectively;p=0.006). Interstitial fibrosis of 40% or more and/or the area of expression of E-cadherin less than 10% of the area of tubulo-interstitium have an unfavorable prognostic value in achieving a renal response in MCN.
Conclusion.If the interstitial fibrosis area is 40% or more and the expression area of E-cadherin is less than 10%, the probability of the absence of a renal response is 93.3% (OR=24.5) even when a hematological response to induction therapy is achieved. The number of protein casts, the prevalence of acute tubular damage and inflammatory interstitial infiltration have not prognostic value.
Autologous haematopoietic stem cell transplantation in patients with multiple myeloma complicated by dialysis-dependent renal failure
Authors: Firsova M. V. , Mendeleeva L. P. , Solovev M. V. , Rekhtina I. G. , Pokrovskaya O. S. , Urnova E. S. , Soboleva N. P. , Dvirnyk V. N. , Klyasova G. A. , Kuzmina L. A. , Savchenko V. G.
Published: September 2020

Aim.To assess the safety and efficacy of autologous haematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma (MM) patients with dialysis-dependent renal failure.
Materials and methods.During a period from May 2010 to December 2016 fourteen MM patients with dialysis-dependent renal failure aged 48 to 65 years underwent auto-HSCT. After the induction therapy complete response, very good partial response, partial response were documented in 64, 29, 7% of patients, respectively. In no case was a renal response achieved. Haematopoietic stem cell mobilization in most patients (13/14) was performed according to the scheme: G-CSF 10 g/kg. Melphalan in 3 dosages was used as pre-transplant conditioning: 100, 140 and 200 mg/m2; 13 patients underwent a single and in one case underwent a tandem auto-HSCT against the background of hemodialysis. Evaluation of the antitumor and renal response was assessed on the 100th day after auto-HSCT. Subsequently, against the background of programmed hemodialysis and in the setting of high-dosed melphalan (100200 mg/m2), 13 patients underwent a single and one patient underwent a tandem auto-HSCT. At +100 days after auto-HSCT, an antitumor response and renal response were assessed.
Results.The period of agranulocytosis after auto-HSCT was from 5 to 12 days (median 8,5) and was accompanied by infectious complications, cardiac and neurological dysfunctions. At +100 days after auto-HSCT, the complete response was confirmed in 71% patients and very good partial response was confirmed in 29% patients. The minimal renal response was registered in 2 patients (14%), hemodialysis was stopped. The transplant-related mortality was absent. After a median follow-up of 53 months 5-year progression-free survival was 59%, and overall survival was 93%.
Conclusion.Carrying out auto-HSCT in patients with dialysis-dependent renal failure contributed to the achievement of a minimal renal response in 14% of cases, which allowed these patients to stop hemodialysis. Patients whose conditioning regimen was performed using melphalan at a dose of 200 mg/m2showed more frequent complications in the early post-transplant period compared to patients who received a lower dose of melphalan (100140 mg/m2). Auto-HSCT in MM patients with dialysis-dependent renal failure is a feasible and effective treatment method, which in some cases contributes to independence from hemodialysis.
The prognostic value of ASXL1 mutation in primary myelofibrosis. Literature review and clinical case description
Authors: Melikyan A. L. , Subortseva I. N. , Gilyazitdinova E. A. , Koloshejnova T. I. , Egorova E. K. , Pustovaya E. I. , Sudarikov A. B. , Abdullaev A. O. , Gorgidze L. A. , Chebotarev D. I.
Published: September 2020

Primary myelofibrosis is a myeloproliferative neoplasm that occurs de novo, characterized by clonal proliferation of stem cells, abnormal expression of cytokines, bone marrow fibrosis, hepatosplenomegaly as a result of extramedullary hematopoiesis, symptoms of tumor intoxication, cachexemia, peripheral blood leukoerythroblastosis, leukemic progression and low survival. Primary myelofibrosis is a chronic incurable disease. The aims of therapy: preventing progression, increasing overall survival, improving quality of life. The choice of therapeutic tactics is limited. Allogenic hematopoietic stem cell transplantation is the only method that gives a chance for a cure. The role of mutations in a number of genes in the early identification of candidates for allogeneic hematopoietic stem cell transplantation is being actively studied. The article describes the clinical case of the detection ofASXL1gene mutations in a patient with prefibrous primary myelofibrosis. The diagnosis was established on the basis of WHO criteria 2016. The examination revealed a mutation ofASXL1. Interferon alfa therapy is carried out, against the background of which clinico-hematological remission has been achieved. Despite the identified mutation, the patient is not a candidate for allogeneic hematopoietic stem cell transplantation. Given the unfavorable prognostic value of theASXL1mutation, the patient is subject to active dynamic observation and aggressive therapeutic tactics when signs of disease progression appear.
Successful use of long-term follow-up in patients with chronic myeloid leukemia with a deep molecular response at reduced doses of 2nd generation tyrosine kinase inhibitors: clinical cases and literature review
Authors: Gurianova M. A. , Chelysheva E. Yu. , Shukhov O. A. , Turkina A. G.
Published: September 2020

Therapy with tyrosine kinase inhibitors (TKI) allows to achieve a deep molecular response in 6070% of patients with chronic myeloid leukemia (CML). According to the current guidelines CML patients receive a long-term treatment with TKI in standard dose. The frequently observed adverse effects (AE) of TKI therapy are mostly dose-dependent. A new treatment approach with TKI use in reduced dose is desirable for the CML patients with existing AE or with a high risk of AE occurrence. We report the two cases of successful long-term treatment of CML patients with reduced doses of second generation TKIs. The aim of the TKI dose reduction was to reduce the clinical manifestations of drug toxicities and to prevent the AE.
Diet therapy for irritable bowel syndrome
Authors: Bakulin I. G. , Avalueva E. B. , Оrеshkо L. S. , Sitkin S. I. , Shevyakov M. A. , Serkova M. U. , Semenova E. A.
Published: September 2020

The review provides present information on the pathogenesis of irritable bowel syndrome (IBS), the relationship of endogenous and exogenous factors with the development of IBS-symptoms, questions of diet therapy are discussed, diets traditionally prescribed in IBS treatment and diets, such as FODMAP and gluten-free diet, which are the most promising and have a positive effect on the symptoms of IBS.
Antibiotic resistance of Helicobacter pylori in the European part of the Russian Federation: first results
Authors: Maev I. V. , Andreev D. N. , Govorun V. M. , Ilina E. N. , Kucheryavyy Yu. A. , Oganesian T. S. , Melnikova E. V. , Zayratyants O. V. , Parfenova T. V. , Dzhedzheia L. V. , Kirillova N. V. , Maevskaya E. A. , Fomenko A. K. , Lobanova E. G. , Zaborovskii A. V. , Kriukov K. A.
Published: September 2020

Aim. Determine the primary antibiotic resistance of Helicobacter pylori (H. pylori) strains isolated from patients living in the European part of the Russian Federation.
Materials and methods. As part of a clinical laboratory study, from 2015 to 2018, 27 gastrobiopsy samples obtained from H. pylori-infected patients were analyzed. H. pylori infection was verified using a rapid urease test or a 13C-urea breath test. The values of the minimum inhibitory concentration (MIC) of antibiotics were determined by the diffusion method using E-test strips (BioMerieux, France) according to the recommendations of the manufacturer. The sensitivity of the isolates was determined for 6 antibacterial drugs (amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, rifampicin).
Results. According to the data obtained, resistance to amoxicillin was 0%, clarithromycin 11.1%, metronidazole 59.3%, levofloxacin 3.7%, tetracycline 0%, and rifampicin 14.8%. Dual resistance to clarithromycin and metronidazole was recorded in two isolates (7.4%).
Conclusion. Thus, the first results of the evaluation of H. pylori antibiotic resistance in the European part of the Russian Federation indicate a low resistance of the microorganism to clarithromycin and quite high to metronidazole.
The eosinophilic esophagitis and IgG4-related disease involving the esophagus
Authors: Bakulina N. V. , Simanenkov V. I. , Vorobyev S. L. , Tikhonov S. V. , Lishchuk N. B. , Bakulin I. G.
Published: September 2020

The study of eosinophilic esophagitis has become a dynamic field with an evolving understanding of the pathogenesis, diagnosis, and treatment. Immunoglobulin G4 (IgG4)-related disease exhibits systemic involvement but very rarely involves the esophagus. The article presents a clinical case: the history of ulcer and stricture of the esophagus in a young man of 17 years. The patient was finally diagnosed with IgG4-related and eosinophilic esophagitis and showed a good response to corticosteroid therapy. We herein report a rare case of dysphagia associated with IgG4-related disease and eosinophilic. We presented a review of modern data on the relationship of eosinophilic esophagitis and pathological IgG4-response.