bluuebunny/crossref_metadata_2025 huggingface dataset:
Regeneration of Electrocatalyst through Li-Ion Insertion
Authors: Sum Jérémy , Durupthy Olivier , Krins Natacha , Laberty-Robert Christel
Published: March 2022

Anatase TiO2 structure has been widely studied as an electrode for Li-ion battery and as electrocatalyst for water splitting. Inserting guest species into TiO2 has been demonstrated as an effective approach to tune the electronic structure and consequently improves the hydrogen evolution reaction (HER) catalytic activity. In this work, by using mesoporous TiO2 electrodes, we have demonstrated the interplays between HER and Li-ion insertion in Water-in-Salt Electrolyte (WISE). Low C-rates favor the electro-catalytic reaction (HER), but the latter does also depend on the amount of Li in the electrode. Finally, this study guides the experimental conditions for an optimum functioning either in battery environment or in electro-catalysis.
Measuring Irreversible Heat Generation in Lithium-Ion Batteries: An Experimental Methodology
Authors: Diaz Laura Bravo , Hales Alastair , Marzook Mohamed Waseem , Patel Yatish , Offer Gregory
Published: March 2022

Lithium-ion battery research has historically been driven by power and energy density targets. However, the performance of a lithium-ion cell is strongly influenced by its heat generation and rejection capabilities which have received less attention. The development of adequate thermal metrics able to capture the anisotropic thermal conductivity and uneven internal heat generation rates characteristic of lithium-ion cells is therefore paramount. The Cell Cooling Coefficient (CCC), in W.K−1, has been introduced as a suitable metric to quantify the rate of heat rejection of a given cell and thermal management method. However, there is no standardised methodology defining how to measure the heat generation capabilities of a cell. In this study, we applied the CCC empirical methodology to evaluate the rates of irreversible heat generation at various operation conditions, providing maps which give a complete insight into cell thermal performance. The maps derived show how the most important operational variables (frequency, C-rate, SOC and temperature) influence the cell thermal performance. These maps can be used along with the CCC by pack engineers to optimise the design of thermal management systems and to down select cells according to their thermal performance.
Novel ITGB2 Mutation Is Responsible for a Severe Form of Leucocyte Adhesion Deficiency Type 1
Authors: Bouhouche Ahmed , Tabache Yasmin , Askander Omar , Charoute Hicham , Mesnaoui Nada , Belayachi Lamiae , El Hafidi Naima , Hardizi Houyam , El Fahime Elmostafa , Erreimi Naima , Barakat Abdelhamid , Khattab Mohammed , Seghrouchni Fouad , El Hassani Amine
Published: March 2022

Leukocyte adhesion deficiency type 1 (LAD1) is a rare autosomal recessive hereditary disorder characterized by recurrent infections, impaired pus formation, delayed wound healing, omphalitis, and delayed separation of the umbilical cord as hallmark features of the disease. It results from mutations in the integrin β2 subunit gene ITGB2, which encodes the integrin beta chain‐2 protein CD18. In this study, we aimed to investigate the case of a five‐month‐old boy who presented with a clinical phenotype and flow cytometry results suggesting LAD1 disease. Sanger sequencing of all exons and intron boundaries of ITGB2 identified a novel in‐frame deletion in exon 7 (ITGB2 c.844_846delAAC, p.Asn282del) in the patient. The p.Asn282del mutation was heterozygous in the child’s parents, whereas it was absent in the 96 control individuals from North Africa. This variant was evaluated by two in silico mutation analysis tools, PROVEAN and MutationTaster, which predicted that the mutation was likely to be pathogenic. In addition, molecular modeling with the YASARA View software suggested that this novel mutation may affect the structure of integrin beta‐2 and, subsequently, its interaction with integrin alpha‐X. In summary, we report a novel pathogenic mutation p.Asn282del associated with LAD1 that expands the mutation diversity of ITGB2 and suggest the combination of flow cytometry and ITGB2 sequencing as a first‐line diagnostic approach for LAD disease.
Haematological Indices and Antioxidant Enzyme Activity in Ghanaian Stroke Patients
Authors: Asmah Richard Harry , Sackey Pomah , Adjei Patrick , Archampong Timothy N. , Attoh Seth , Doku Derek , Quarchie Marjorie , Botchway Felix , Adedia David , Donkor Eric Sampene
Published: March 2022

Background. Stroke is a cardiovascular disorder causing mortality globally and long‐lasting harm worldwide. The disease occurs when the blood flow to the brain is either interrupted or blocked. This disruption leads to the increase in reactive oxygen species (ROS), especially superoxide free radicals, resulting in oxidative stress. The superoxide radicals are removed by superoxide dismutase (SOD), a key antioxidant enzyme. In this work, we investigated haematological indices and superoxide dismutase enzyme activity in Ghanaian patients with stroke and healthy control participants. Materials and Methods. Thirty stroke patients attending a stroke clinic and thirty apparently healthy control participants were recruited into the study. Blood samples were collected to determine haematological indices and SOD enzyme activity in red blood cells. Results. The stroke patients had significantly high blood parameters such as white blood cell (p < 0.001), neutrophil (p < 0.001), lymphocyte (p = 0.003), and eosinophil (p < 0.001) comparing with study participants without stroke, who were the control group in the study. Other blood parameters such as red blood cell, (p < 0.001), haemoglobin (p < 0.001), and haematocrit (p < 0.001) levels and mean cell haemoglobin concentration (p = 0.030), platelet (p = 0.010), and plateletcrit (p = 0.027) were high in stroke patients comparing with study control participants and statistically significant. Blood lymphocyte levels observed in stroke patients correlated negatively and significantly with SOD activity levels. SOD activity levels were significantly lower in stroke patients compared with the control group (p < 0.001). Low values of the antioxidant enzyme SOD activity levels, lymphocytes, and high values of plateletcrit were significant predictors of stroke. Conclusion. Haematological parameters such as WBC, lymphocyte, platelet levels, and red cell indices were significantly different in the stroke patients being studied. There was negative correlation between lymphocyte significantly with SOD activity and high oxidative stress in stroke patients compared with the control group. Lymphocytes and plateletcrit levels were also good predictors of the occurrence of stroke.
5,8-Dihydroxy-4

′

, 7-dimethoxyflavone Attenuates TNF-α-Induced Expression of Vascular Cell Adhesion Molecule-1 through EGFR/PKCα/PI3K/Akt/Sp1-Dependent Induction of Heme Oxygenase-1 in Human Cardiac Fibroblasts
Authors: Yang Chien-Chung , Hsiao Li-Der , Shih Ya-Fang , Lin Hsin-Hui , Yang Chuen-Mao
Published: March 2022

Recently, we found that 5,8-dihydroxy-4

’

,7-dimethoxyflavone (DDF) upregulated the expression of heme oxygenase (HO)-1 via p38 mitogen-activated protein kinase/nuclear factor-erythroid factor 2-related factor 2 (MAPK/Nrf2) pathway in human cardiac fibroblasts (HCFs). However, the alternative processes by which DDF induces the upregulation of HO-1 expression are unknown. Activation of epidermal growth factor receptor (EGFR), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and protein kinase C (PKC)α may initiate specificity protein (Sp)1 activity, which has been reported to induce expression of antioxidant molecules. Thus, we explored whether these components are engaged in DDF-induced HO-1 upregulation in HCFs. Western blotting, promoter-reporter analyses, and real-time polymerase chain reactions were adopted to measure HO-1 and vascular cell adhesion molecule (VCAM)-1 expressions in HCFs. Respective small interfering (si)RNAs and pharmacological inhibitors were employed to investigate the signaling components engaged in DDF-induced HO-1 upregulation. The chromatin immunoprecipitation assay was conducted to detect the binding interaction of Sp1 and antioxidant response elements (ARE) on the promoter of HO-1. An adhesion assay of THP-1 monocyte was undertaken to examine the functional effect of HO-1 on tumor necrosis factor (TNF)-α-induced VCAM-1 expression. DDF stimulated the EGFR/PKCα/PI3K/Akt pathway leading to activation of Sp1 in HCFs. The roles of these protein kinases in HO-1 induction were ensured by transfection with their respective siRNAs. Chromatin immunoprecipitation assays revealed the interaction between Sp1 and the binding site of proximal ARE on the HO-1 promoter, which was abolished by glutathione, AG1478, Gö6976, LY294002, or mithramycin A. HO-1 expression enhanced by DDF abolished the monocyte adherence to HCFs and VCAM-1 expression induced by TNF-α. Pretreatment with an inhibitor of HO-1: zinc protoporphyrin IX reversed these inhibitory effects of HO-1. We concluded that DDF-induced HO-1 expression was mediated via an EGFR/PKCα/PI3K/Akt-dependent Sp1 pathway and attenuated the responses of inflammation in HCFs.
SNHG1/miR-145-5p/KLF5 Axis Participates in Regulating the Proliferation and Migration of Oral Squamous Cell Cancer
Authors: Xin Haiyan , Feng Ziyan , Yao Chao
Published: March 2022

We aimed to clarify the molecular mechanism of lncRNA SNHG1 in regulating the OSCC process. Clinical samples of OSCC were collected for detecting the differential level of SNHG1 by qRT-PCR. Pathological indexes of OSCC patients were analyzed for uncovering the prognostic value of SNHG1. The interaction between SNHG1 and miR-145-5p was assessed through the bioinformatics method and dual-luciferase reporter assay. Their coregulation on proliferative and migratory functions of Tca8113 and CAL-27 cells was explored by the CCK-8, EdU, and Transwell assay. Finally, the regulatory effect of miR-145-5p on its downstream gene KLF5 was evaluated. SNHG1 was abnormally upregulated in OSCC samples and linked to a poor prognosis of OSCC patients. Serving as an oncogene, SNHG1 strengthened proliferative and migratory functions of Tca8113 and CAL-27 cells. miR-145-5p was a key downstream target inducing the oncogenic role of SNHG1 in the OSCC process with KLF5 as its downstream gene. SNHG1/miR-145-5p/KLF1 axis is responsible for driving the malignant process of OSCC.
A Controllable Secure Blockchain-Based Electronic Healthcare Records Sharing Scheme
Authors: Li Honglei , Yang Xiao , Wang Hongxin , Wei Wujia , Xue Weilian
Published: March 2022

The sharing of electronic healthcare records (EHRs) is important to healthcare and medical research. However, institutions are faced with difficulties in privacy protection and efficiently secure data exchange. The main objective of this study is to propose a controllable secure blockchain-based EHRs sharing scheme. For this purpose, blockchain technologies are combined with interplanetary file systems (IPFS) to provide efficient secure EHRs sharing. Firstly, the IPFS-based EHR file system (IEFS) is designed to save and share large-size EHR files among medical institutions. With the high-throughput content-addressed block storage model and appropriate redundant backup of IPFS, IEFS is tamper-resistant and free of a single point of failure. Secondly, the blockchain is used to implement the blockchain-based EHR abstract system (BEAS) to manipulate EHR abstracts access. In BEAS, the EHR file addresses generated by IEFS are encrypted and saved in EHR abstracts for privacy protection. Since EHR abstracts are encrypted by patients’ public keys, the sharing of EHR files is under the control of patients. In our experiment, a prototype system is developed to validate the proposed scheme. The experimental results showed that (1) EHRs are securely shared under the control of patients and (2) EHR files are retrieved at an acceptable speed supported by IPFS technology. In this paper, solutions to some important practical issues such as incapacitated patients, encryption key forgetting/missing, and efficient interaction of doctors with EHRs sharing scheme are also seriously discussed.
Research on Motion Behavior and Quality-of-Life Health Promotion Strategy Based on Bee Colony Optimization
Authors: Chen Ruibi
Published: March 2022

Quality of life is a kind of sensory experience of people's physical health, social ability, and personal overall situation. Correct understanding and evaluation of the quality of life is conducive to human rational planning and control of life resources, promote physical and mental health, and improve the quality of life. In order to further explain the positive impact of physical exercise behavior on promoting physical and mental health, based on the bee colony optimization algorithm this paper analyzes the relationship between physical exercise behavior and quality of life and discusses the role of physical exercise behavior in promoting physical and mental health. The essential attributes and sociological significance of sports determine that sports play a unique role in providing people with social support. The quality of life score increases as the duration of the exercise increases. The theory and methods of defense and treatment advocated by sports thoughts will also have a positive effect on individuals avoiding and getting rid of mental illness. Teachers who have lower exercise time and frequency of exercise should also develop a step-by-step exercise program to strive to join them in the sports population.
Inhibition of microRNA-665 Alleviates Septic Acute Kidney Injury by Targeting Bcl-2
Authors: Qi Yongjie , Han Yue , Chen Chen , Xue Yingchang , Jiao Nianhui , Li Xuejun
Published: March 2022

Sepsis can easily cause acute kidney injury (AKI) and seriously endanger human health. This article aims to investigate and study the role of microRNA-665 (miR-665) in septic AKI and the underlying molecular mechanism. Lipopolysaccharide (LPS) was used to construct cell and animal models of septic AKI. The expression of miR-665 in cells and kidney tissues was detected by quantitative reverse-transcription polymerase chain reaction (RT-PCR). The contents of inflammatory factors (TNF-α, IL-1β, and IL-6) in the cell supernatant were detected using commercial kits. Renal tissue damage was observed by hematoxylin-eosin (HE) staining. Kidney function was assessed by serum Cr, serum BUN, and urine NAG levels. The apoptosis of HK-2 cells was analyzed by flow cytometry and TUNEL staining. Luciferase activity assay was performed for the verification of the target of miR-665. The expression of miR-665 was increased in the cell model and animal model of septic AKI constructed by LPS. By transfecting miR-665 inhibitor in HK-2 cells and injecting miR-665 antagomir (antagomiR-665) through the tail vein of rats, the expression of miR-665 in HK-2 cells and rat kidneys was remarkably reduced. Silencing miR-665 dramatically inhibited the expression of inflammatory factors (TNF-α, IL-1β, and IL-6) in LPS-induced HK-2 cells and reduced LPS-induced apoptosis in HK-2 cells. At the same time, the levels of serum Cr, serum BUN, and urine NAG decreased markedly, and the damage of the kidney was also alleviated. Finally, luciferase reporter experiments demonstrated that miR-665 directly targets Bcl-2. We revealed that miR-665 expression was increased in septic AKI, and silencing miR-665 could inhibit LPS-induced inflammation and apoptosis of the kidney by targeting Bcl-2, thereby improving renal function.
Topological Coindices and Quantitative Structure-Property Analysis of Antiviral Drugs Investigated in the Treatment of COVID-19
Authors: Kirmani Syed Ajaz K. , Ali Parvez , Ahmad Jawed
Published: March 2022

SARS-CoV-2 is a new strain of coronavirus family that has never been previously detected in humans. This has grown into a huge public health issue that has affected people all around the world. Presently, there is no specific antiviral treatment for COVID-19. To tackle the outbreak, a number of drugs are being explored or have been utilized based on past experience. A molecular descriptor (or topological index) is a numerical value that describes a compound’s molecular structure and has been successfully employed in many QSPR/QSAR investigations to represent several physicochemical attributes. In order to determine topological characteristics of graphs, coindices (topological) take nonadjacent pair of vertices into account. In this study, we introduced CoM-polynomial and numerous degree-based topological coindices for several antiviral medicines such as lopinavir, ritonavir remdesivir, hydroxychloroquine, chloroquine, theaflavin, thalidomide, and arbidol which were studied using the CoM-polynomial approach. In the QSPR model, the linear regression approach is used to analyze the relationships between physicochemical properties and topological coindices. The findings show that the topological coindices under investigation have a substantial relationship with the physicochemical properties of possible antiviral medicines in question. As a result, topological coindices may be effective tools for studying antiviral drugs in the future for QSPR analyses.
Study on the Spatial Structure and Evolution Stage of Industrial R&D Ecosystem Based on Evolutionary Biology
Authors: Yan Ningning
Published: March 2022

The insufficient innovation ability is the biggest bottleneck for the upgrading of creative industry in China. Thus, it is an important way to structure the good R&D innovative ecosystem around perfecting the innovative chain for improving the innovation ability of creative industry. This paper discusses the theoretical connotation of the R&D innovation ecosystem of creative industry, studies the spatial structure of the R&D innovation ecosystem, and proposes the fact that the innovative population of R&D innovation ecosystem in creative industry can be divided into original innovative population, technological innovation population, innovation service population, innovation input population, and system innovation population. The research on the demand, financing, and business model of R&D breakthrough innovation in China’s industry cannot be separated from the analysis of the evolution stages of various industries, because different strategies need to be formulated at different stages of development, and it is very important to accurately grasp the stage of industrial development. By introducing logistic curve equation, the breakthrough innovation of industrial R&D is divided into four stages: incubation stage, growth stage, evolution stage, and maturity stage, and the different characteristics of different stages of industry development are analyzed. Taking the breakthrough innovation of R&D in industry as an example, this paper uses the logistic empirical model based on factor analysis to study it. The results show that the breakthrough innovation of R&D in industry has entered a maturity stage.
Mycotic Aneurysm with Iliac Artery-Colonic Fistula
Authors: Viet Dung Le , Mai Hien Ma , Bich Nguyet Dang-Thi , Tra My Thieu-Thi , Minh Duc Nguyen
Published: March 2022

Although mycotic (infected) aneurysms are uncommon, they can affect any artery. The most frequently involved vessel is the aorta as well as femoral and cerebral arteries. A vascular-colonic fistula from infected aneurysms is even rarer, which remains a challenge for diagnosis and treatment. In this case report, we aimed to illustrate an 89-year-old man presenting initially with an aneurysm of the right common iliac artery. Forty days later, this lesion was infected and produced fresh blood in the rectum and sigmoid colon observed by colonoscopy. The final diagnosis of this case was a right common iliac artery aneurysm-colonic fistula due to infection. The patient was successfully diagnosed and treated with surgery at our hospital.
Pricing Problem in the E-Commerce Low-Carbon Supply Chain under Asymmetric Fairness Preferences
Authors: Song Lei , Xin Qi , Wu Cheng-Min
Published: March 2022

Given the different fairness preferences of online retailers and their investment in emission reduction and revenue sharing with manufacturers, an e-commerce low-carbon supply chain decision model was established using Stackelberg game theory under three circumstances: no fairness preference, symmetric fairness preferences, and asymmetric fairness preferences. Results reveal that the asymmetric fairness preference behaviors of online retailers weaken the manufacturers’ profits, where the online retailer’s utility is negatively correlated with its asymmetric fairness preference coefficient. The real fairness preference coefficient of the online retailer estimated by the manufacturer is negatively correlated with the manufacturer’s wholesale price and carbon emission reduction. The revenue sharing proportion of the manufacturer presents a positive correlation with its wholesale price but shows no correlation with the retail price, the green degree, or the supply chain profit. Within a feasible region, the proportion of the online retailer’s investment in emission reduction is positively correlated with the manufacturer’s profit, the online retailer’s utility, the total utility of the supply chain, the carbon emission reduction, the product’s retail price, and the product’s wholesale price.
Attention-Enhanced One-Stage Algorithm for Traffic Sign Detection and Recognition
Authors: Huang He , Liang Qice , Luo Dean , Lee Dong Ha
Published: March 2022

Detection and recognition of traffic signs are the keys to creating advanced driving assistance systems. Making highly precise maps also requires the identification and extraction of such road elements as traffic signs. Traditional detection and recognition methods no longer meet today’s needs, and object recognition algorithms based on deep learning have become the mainstream solution. However, current algorithms have limitations. The recognition speed of one-stage strategy algorithms is fast, but recognition accuracy is not satisfactory especially for small objects. The accuracy of two-stage algorithms is higher, but the recognition speed is extremely slow. This paper solves these problems with a proposed parallel attention convolution module, a channel attention pyramid network, and a loss function diagonal and center point IoU based on the YOLOv3 algorithm. The improved models in this paper are compared with SSD, YOLOv3, and Faster RCNN. Experimental results show that the proposed models have some improvement over the above models: the mAP of the models with PACM, CAFPN, and DCPIoU was 76.02%, compared with SSD300, SSD500, Faster RCNN, and YOLOv3, which had improvements of 9.27%, 6.93%, 2.94, and 5.3%, respectively. And the FPS of the improved model is basically the same as the original YOLOv3, without reducing the real-time performance.
Standardized Human Platelet Lysates as Adequate Substitute to Fetal Calf Serum in Endothelial Cell Culture for Tissue Engineering
Authors: Peters Katharina , Helmert Tania , Gebhard Susanne , Mailänder Volker , Unger Ronald E. , Nezi-Cahn Sandra , Hasenburg Annette , Heller Martin , Schwab Roxana , Brenner Walburgis
Published: March 2022

Fetal calf serum (FCS) is used for in vitro cell culture, as it provides the cells with various growth‐promoting compounds. For applications in humans, FCS does not meet the required safety standards and should be replaced by an appropriate substitute. This study analyzed the suitability of using human platelet lysate (hPL) as a substitute for FCS in endothelial cell cultures for in vitro and in vivo tissue engineering applications. The focus was placed on standardized, commercially available hPLs (MultiPL’30, MultiPL’100), which are approved for applications in humans, and compared to laboratory‐prepared hPLs (lp‐hLP). Human umbilical vein endothelial cells (HUVEC) were cultured with FCS or with different hPLs. Cell morphology, proliferation, viability, apoptosis, and necrosis, as well as the organization of vascular structures, were assessed. No morphological changes were noticed when FCS was replaced by standardized hPLs in concentrations of 1‐10%. In contrast, the use of lp‐hLPs led to irregular cell shape and increased vacuolization of the cytoplasm. HUVEC proliferation and viability were not compromised by using media supplemented with standardized hPLs or pl‐hPLs in concentrations of 1‐10%, compared to cells grown in media supplemented with 20% FCS. The apoptosis rate using lp‐hPLs was higher compared to the use of standardized hPLs. The necrosis rate tended to be lower when FCS was replaced by hPLs. HUVEC formed more pronounced capillary‐like structures when the media were supplemented with hPLs instead of supplementation with FCS. Thus, compared to the use of FCS, the use of hPLs was beneficial for the growth and optimal expression of functional endothelial cell characteristics during in vitro experiments. Commercially available hPLs proved to be particularly suitable, as they led to reproducible results during in vitro experiments, while meeting the safety requirements for in vivo use.
Multisource DOA Estimation in Impulsive Noise Environments Using Convolutional Neural Networks
Authors: Chen Dong , Joo Young Hoon
Published: March 2022

This work proposes an effective high-resolution multisource direction-of-arrival (DOA) estimation method in impulsive noise scenarios based on convolutional neural networks (CNNs). First of all, the array observation matrix is preprocessed and fed into a denoising network to suppress outliers and filter out impulsive noise. Secondly, the denoising network output is fed into a model order selection network to estimate the model order. Next, according to the estimation, the denoising network output is fed into a DOA subnetwork corresponding to the model order in a DOA network to estimate the DOA of each signal. Comprehensive simulations demonstrate that, in the presence of impulsive noise, the proposed method is effective and superior in accuracy and computation speed for multisource DOA estimation. Therefore, it is concluded that CNN can be well generalized for DOA estimation.
Prevalence of Giardiasis and Entamoeba Species in Two of the Six Governorates of Kuwait
Authors: AlAyyar Rania M. , AlAqeel Abdullah A. , AlAwadhi Muna Sh.
Published: March 2022

Intestinal parasitic infections are a global concern owing to elevated rates of morbidity and mortality in many parts of the world. Increased rates of intestinal parasitic infections are observed in developing and low-income countries. In Kuwait, many expatriates and foreigners hail from endemic countries, thus increasing the rate and risk factor of infection. This retrospective study is aimed at assessing the prevalence of Giardia lamblia and Entamoeba sp. in stool samples handled by two of Kuwait’s general hospitals during the period from January 2018 to July 2019: Mubarak Al Kabeer (serving Hawalli governorate population) and Aladan hospitals (serving Mubarak Al Kabeer governorate population) serving 27% of total Kuwait population with Kuwaitis making up only 32%. A total of 9,653 samples were tested for consistency and the availability of any parasitic particles using visual, direct wet mount, and concentration method. Statistical analysis was implemented using SPSS statistical program, at

p
<
0.05

. Of all the 9,653 tested stool samples, 74 were positive for G. lamblia or Entamoeba sp. This represented a mere 1% rate of infection and showed no significant correlation to the prevalence of intestinal parasite infections in Kuwait. On the other hand, comparing the rate of infection in different seasons revealed an increased rate of infection during spring compared to other seasons (

p
=
0.03

). Findings revealed low rates of intestinal parasitic infection within the two governorates of Kuwait representing no statistical significance to the distribution of the investigated parasites in Kuwait. This may be attributed to improved living conditions and healthcare. Elevated infection rates in spring in relation to other seasons raised the importance of increasing public awareness during camping season for maintaining proper personal hygiene and waste management to contain and decrease the rate on infection.
Animation Image Art Design Mode Using 3D Modeling Technology
Authors: Tan Shuqing
Published: March 2022

This paper starts with the external visual performance of animation characters, discusses the design style of three-dimensional animation characters, and integrates with traditional art, and makes a new research and attempt from the combination of art and technology, so that nonprofessionals can easily design three-dimensional animation characters. Aiming at the problem of low recognition level of behavior control data points in traditional 3D virtual animation model method, a method of role modeling and behavior control in 3D virtual animation design is designed. Based on the physical engine, a dynamic model of the character skeleton is established, and the joint motion trajectory is simulated to complete the real-time rendering of the effect. Combined with the case analysis, it is discussed from the aspects of animation character modeling, user experience, and so on. Experimental results show that, compared with traditional methods, the data points collected by the proposed method in the process of character behavior control are more dense, the animation effect is more realistic, and it is highly effective and superior.
Multisource Thermal Model Describing Transverse Momentum Spectra of Final-State Particles in High-Energy Collisions
Authors: Liu Fu-Hu , Chen Jia-Yu , Zhang Qiang
Published: March 2022

In this minireview article, the transverse momentum spectra of final-state particles produced in high-energy hadron-hadron, hadron-nucleus, and nucleus-nucleus collisions described by the multisource thermal model at the quark or parton level are summarized. In the model, the participant or contributor quarks or partons are considered to contribute together to the transverse momentum distribution of final-state particles with different modes of contributions. The concrete mode of contribution is generally determined by the difference of azimuthal angles of contributor partons in their emissions.
Analyzing the Performance of Machine Learning Techniques in Disease Prediction
Authors: Phasinam Khongdet , Mondal Tamal , Novaliendry Dony , Yang Cheng-Hong , Dutta Chiranjit , Shabaz Mohammad
Published: March 2022

The history of data stored can be used to forecast potential patterns and help companies make competitive decisions to increase their success and benefits. Many analysts look at healthcare sector data to identify and forecast illnesses in order to benefit patients and physicians in a variety of ways. This study is concerned with the diagnosis and estimation of heart disease. Heart disease is one of the most dangerous illnesses for humans, leading to death all over the world. Many different groups of researchers have used knowledge exploration methods in diverse fields to forecast heart disease and have shown acceptable degrees of precision. There were no real-time methods for analyzing and forecasting heart disease in its early stages. For the prediction of heart disease, decision trees are used to analyze various training and evaluation datasets. Classification algorithms such as Naive Bayes, ID3, C4.5, and SVM are being investigated. The UCI machinery heart disease data set is used in experimental studies.
Subclass of Analytic Functions Related with Pascal Distribution Series
Authors: Shammaky Amnah E. , Frasin Basem Aref , Seoudy Tamer M.
Published: March 2022

The prime purpose of this article is to derive a necessary and sufficient condition for a linear operator associated with the Pascal distribution series to be in the class of analytic functions. Moreover, inclusion relation and an integral operator linked to the Pascal distribution series is considered. We have also provided some results as corollaries of our theorems.
[Retracted] Detection of Breast Cancer Using Histopathological Image Classification Dataset with Deep Learning Techniques
Authors: Reshma V. K. , Arya Nancy , Ahmad Sayed Sayeed , Wattar Ihab , Mekala Sreenivas , Joshi Shubham , Krah Daniel
Published: March 2022

Cancer is one of the top causes of mortality, and it arises when cells in the body grow abnormally, like in the case of breast cancer. For people all around the world, it has now become a huge issue and a threat to their safety and wellbeing. Breast cancer is one of the major causes of death among females all over the globe, and it is particularly prevalent in the United States. It is possible to diagnose breast cancer using a variety of imaging modalities including mammography, computerized tomography (CT), magnetic resonance imaging (MRI), ultrasound, and biopsies, among others. To analyze the picture, a histopathology study (biopsy) is often performed, which assists in the diagnosis of breast cancer. The goal of this study is to develop improved strategies for various CAD phases that will play a critical role in minimizing the variability gap between and among observers. It created an automatic segmentation approach that is then followed by self‐driven post‐processing activities to successfully identify the Fourier Transform based Segmentation in the CAD system to improve its performance. When compared to existing techniques, the proposed segmentation technique has several advantages: spatial information is incorporated, there is no need to set any initial parameters beforehand, it is independent of magnification, it automatically determines the inputs for morphological operations to enhance segmented images so that pathologists can analyze the image with greater clarity, and it is fast. Extensive tests were conducted to determine the most effective feature extraction techniques and to investigate how textural, morphological, and graph characteristics impact the accuracy of categorization classification. In addition, a classification strategy for breast cancer detection has been developed that is based on weighted feature selection and uses an upgraded version of the Genetic Algorithm in conjunction with a Convolutional Neural Network Classifier. The practical application of the suggested improved segmentation and classification algorithms for the CAD framework may reduce the number of incorrect diagnoses and increase the accuracy of classification. So, it may serve as a second opinion tool for pathologists and aid in the early detection of diseases.
Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children
Authors: Cheng Yanli , Hao Guoping , Wang Xiaohuan , Lu Haiyan , Wang Jing , Suo Taoli , Hou Zhaohui , Guo Huimin , Zhang Shixun
Published: March 2022

Objective. To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). Methods. The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete remission was detected by RT-PCR to explore its possible involvement in the pathogenesis of ALL. The proliferation and apoptosis of Jurkat cells transfected with lncRNA-pvt1 were observed by MTT and flow cytometry. Results. lncRNA-pvt1 expression was upregulated in bone marrow of ALL patients. Knockdown of lncRNA-pvt1 inhibited Jurkat cell proliferation and increased its apoptosis rate. Conclusion. Silencing lncRNA-pvt1 expression can inhibit the development of ALL.
Experimental Investigation Monitoring the Saturated Line of Slope Based on Distributed Optical Fiber Temperature System
Authors: Li Feng , Qin Weixing , Hu Huiren
Published: March 2022

The position of the saturated line is an important basis for evaluating the stability of the slope, and the traditional sensors cannot be monitored for a long time because of poor durability and anti-interference. A method for measuring the saturated line with distributed optical fiber temperature measurement technology was proposed, and the one-dimensional and two-dimensional model experiments of measuring the saturated line at three kinds of electron flow (5 A, 10 A, and 15 A) were conducted, and their measuring data were carefully analyzed. The results showed the three stages of the optical fiber temperature difference with time: sudden-rising, fast-rising, and slow-rising. The temperature rising rate and stable temperature difference at the position of the saturated line are between saturated soil and unsaturated soil. The fiber optic temperature increases with the increment of heating electron flow, which also demonstrates stability and repeatability.
Multiple Coronary Fistulas as a Rare Cause of Stable Angina Pectoris
Authors: Habek Jasna Čerkez , Friščić Tea , Šikić Jozica , Perčić Marko , Strinić Dean , Perčić Daria Ljubas
Published: March 2022

Congenital coronary artery-left ventricular multiple microfistulas (CA-LVMMFs) are rare anomalies in adults. They are more often found in female patients, and they usually originate from the distal segments of the coronary arteries, but they can originate from a proximal segments of a coronary arteries, and these patients are likely to be identified and treated in the pediatric age group. They are mostly asymptomatic. When symptoms and complications occur, they include angina, myocardial infarction, atrial heart failure, arrhythmias, and endocarditis. The management of CA-LVMMFs is controversial, but it is generally agreed that conservative medical management is the primary treatment of choice. Our case describes a rare form of CA-LVMMFs draining into the left ventricle in a female patient presenting with fatigue, atypical anginal symptoms, atrial fibrillation, and premature ventricular complexes, without concomitant obstructive coronary artery disease.
Football Teaching Quality Evaluation and Promotion Strategy Based on Intelligent Algorithms in Higher Vocational Colleges
Authors: Jiao Xiance , Li Zefeng
Published: March 2022

With the continuous deepening of the education reform, the number of students in higher vocational college (HVC) has increased, which puts forward higher requirements for the overall development of talents. Football is a relatively common sport in HVC with a certain degree of regularity and difficulty. Therefore, how to improve the level and the quality of teaching through scientific and reasonable teaching methods has become one of the problems that need to be solved in HVC. This article mainly focuses on the analysis and research of the traditional teaching mode and students’ learning situation based on the intelligent algorithm and puts forward effective improvement suggestions and strategies for reference. This article uses questionnaire surveys and data analysis methods to understand the evaluation results of the school’s teachers and students on the teaching quality (TQ) of the football course and the necessity of implementing improvement strategies through questionnaire surveys. According to the survey results, most of the interviewees had a high evaluation of the TQ of the school’s football course. 46 of the teachers and students who participated in the evaluation rated the school’s football course teaching methods as excellent, and only 2 rated it as passing. In addition, 49 of the teachers and students interviewed believe that it is necessary to optimize the strength of teachers, followed by perfecting the equipment configuration of the venue.
Technical Evaluation of Commercial Sperm DFI Quality Control Products in SCSA Testing
Authors: Pang Tao , Zhang Xinzong
Published: March 2022

With the increase in population and the advancement of medicine, people even more hope that their offspring will be healthier. DNA fragmentation rate is currently one of the more common indicators for evaluating sperm fertility and predicting the outcome of pregnancy. In order to evaluate the technical performance and application value of commercial sperm DFI (DNA fragmentation index) quality control products in the flow cytometry sperm chromatin structure analysis (SCSA), this paper uses flow cytometry to test commercial sperm DFI quality control products (Celula) and laboratory routine self-made DFI quality control products. In this paper, the quality control of new commercial sperm DFI and laboratory-made quality control were compared and tested for 30 consecutive days. And this paper monitors the response of commercial quality control products to the interference of key reagent parameters. This paper compares the stability of the test results of two quality control products and their sensitivity to the interference of key performance parameters of the detection reagent. Experimental results show that commercial sperm DFI quality control products can simulate sperm DNA damage to achieve accurate detection of DNA integrity. The stability of commercial sperm DFI quality control (CV = 2.47%) is better than that of laboratory-made quality control (CV = 11.22%). The new commercial sperm DFI quality control product can sensitively detect changes in the concentration of acidified solution and staining solution at the same time. It can effectively control the quality of detection reagents and experimental procedures. The new commercial sperm DFI quality control product can effectively control sperm DNA integrity testing. It can be used as an external quality control product for quality control of test results to ensure that more accurate test results are provided to the clinic.
Primary Ovarian Failure in Addition to Classical Clinical Features of Coats Plus Syndrome in a Female Carrying 2 Truncating Variants of CTC1
Authors: Riquelme Joel , Takada Sanami , van Dijk Tessa , Peña Fernanda , Boogaard Merel W. , van Duyvenvoorde Hermine A. , Pico-Knijnenburg Ingrid , Wit Jan M. , van der Burg Mirjam , Mericq Veronica , Losekoot Monique
Published: March 2022

Coats plus syndrome is an autosomal recessive multisystemic and pleiotropic disorder affecting the eyes, brain, bone, and gastrointestinal tract, usually caused by compound heterozygous variants of the conserved telomere maintenance component 1 gene (CTC1), involved in telomere homeostasis and replication. So far, most reported patients are compound heterozygous for a truncating mutation and a missense variant. The phenotype is believed to result from telomere dysfunction, with accumulation of DNA damage, cellular senescence, and stem cell depletion. Here, we report a 23-year-old female with prenatal and postnatal growth retardation, microcephaly, osteopenia, recurrent fractures, intracranial calcification, leukodystrophy, parenchymal brain cysts, bicuspid aortic valve, and primary ovarian failure. She carries a previously reported maternally inherited pathogenic variant in exon 5 (c.724_727del, p.(Lys242Leufs*41)) and a novel, paternally inherited splice site variant (c.1617+5G>T; p.(Lys480Asnfs*17)) in intron 9. CTC1 transcript analysis showed that the latter resulted in skipping of exon 9. A trace of transcripts was normally spliced resulting in the presence of a low level of wild-type CTC1 transcripts. We speculate that ovarian failure is caused by telomere shortening or chromosome cohesion failure in oocytes and granulosa cells, with early decrease in follicular reserve. This is the first patient carrying 2 truncating CTC1 variants and the first presenting primary ovarian failure.
Comparing Mentalizing Abilities in Older Adults with and without Common Mental Disorders
Authors: Peters Meinolf , Schulz Holger
Published: March 2022

Introduction: The concept of mentalization is of central importance not only in modern psychotherapy but also in geriatric psychotherapy. In relation to older people, deficits in some aspects of the ability to mentalize, such as the theory of mind (ToM), affect perception, and metacognitive skills, are known. However, little is known about the mentalization ability of older people with mental disorders. The aim of the present study was to investigate the mentalizing abilities of older patients with depressive and anxious symptoms. Methods: In this study, the ability to mentalize using the Mentalization Questionnaire (MZQ), the HEALTH-49 questionnaire, Trail-Making Test (executive functions), and Reading-the-Mind-in-the-eyes-test (ToM) was studied in a clinical (n = 150) and a nonclinical comparison sample of people (n = 150) in different age groups (40–54, 55–69, ≥70). The evaluation of the data was conducted with different statistical methods, especially variance and regression analyses. Results: The clinical sample of all age groups showed significantly poorer mentalizing skills than the nonclinical samples. There were large correlations to health-related aspects. Additionally, in the regression analysis, only the setting variable (clinical vs. nonclinical) had an influence on the MZQ score and neither gender, education, executive functions nor ToM had a significant influence. Age also had no effect and did not correlate with MZQ scores but did correlate negatively with ToM. Conclusions: The results show the importance of mentalization concepts for mental disorders in patients in the second half of life. There are indications of an imbalance of different aspects of mentalizing ability, especially between self- and other-related mentalizing abilities. Improving this balance could be a goal of therapeutic interventions.
Out-Of-Pocket Expenditure Associated with Physical Inactivity, Excessive Weight, and Obesity in China: Quantile Regression Approach
Authors: Zhao Yang , He Li , Marthias Tiara , Ishida Marie , Anindya Kanya , Desloge Allissa , D’Souza Monique , Cao Gaofang , Lee John Tayu
Published: March 2022

Introduction: Previous studies exploring associations of physical inactivity, obesity, and out-of-pocket expenditure (OOPE) mainly used traditional linear regression, and little is known about the effect of both physical inactivity and obesity on OOPE across the percentile distribution. This study aims to assess the effects of physical inactivity and obesity on OOPE in China using a quantile regression approach. Methods: Study participants included 10,687 respondents aged 45 years and older from the recent wave of the China Health and Retirement Longitudinal Study in 2015. Linear regression and quantile regression models were used to examine the association of physical activity, body weight with annual OOPE. Results: Overall, the proportion of overweight and obesity was 33.2% and 5.8%, respectively. The proportion of individuals performing high-level, moderate-level, and low-level physical activity was 55.2%, 12.7%, and 32.1%, respectively. The effects of low-level physical activity on annual OOPE were small at the bottom quantiles but more pronounced at higher quantiles. Respondents with low-level activity had an increased annual OOPE of 26.9 USD, 150.3 USD, and 1,534.4 USD, at the 10th, 50th, and 90th percentiles, respectively, compared with those with high-level activity. The effects of overweight and obesity on OOPE were also small at the bottom quantiles but more pronounced at higher quantiles. Conclusion: Interventions that improve the lifestyles and unhealthy behaviors among people with obesity and physical inactivity are likely to yield substantial financial gains for the individual and health systems in China.