bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: The Liver Cancer Pooling Project
Authors: Petrick Jessica L. , Freedman Neal D. , Graubard Barry I. , Sahasrabuddhe Vikrant V. , Lai Gabriel Y. , Alavanja Michael C. , Beane-Freeman Laura E. , Boggs Deborah A. , Buring Julie E. , Chan Andrew T. , Chong Dawn Q. , Fuchs Charles S. , Gapstur Susan M. , Gaziano John Michael , Giovannucci Edward L. , Hollenbeck Albert R. , King Lindsay Y. , Koshiol Jill , Lee I-Min , Linet Martha S. , Palmer Julie R. , Poynter Jenny N. , Purdue Mark P. , Robien Kim , Schairer Catherine , Sesso Howard D. , Sigurdson Alice J. , Zeleniuch-Jacquotte Anne , Wactawski-Wende Jean , Campbell Peter T. , McGlynn Katherine A.
Published: April 2023

Abstract
Background: Coffee consumption has been reported to be inversely associated with hepatocellular carcinoma (HCC), the most common type of liver cancer. Caffeine has chemopreventive properties, but whether caffeine is responsible for the coffee–HCC association is not well studied. In addition, few studies have examined the relationship by sex, and no studies have examined whether there is an association between coffee and intrahepatic cholangiocarcinoma (ICC), the second most common type of liver cancer.

Methods: In the Liver Cancer Pooling Project, a consortium of U.S.-based cohort studies, data from 1,212,893 individuals (HCC, n = 860; ICC, n = 260) in nine cohorts were pooled. Multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) were estimated using proportional hazards regression.

Results: Higher coffee consumption was associated with lower risk of HCC (HR>3 cups/day vs. non-drinker, 0.73; 95% CI, 0.53–0.99; Ptrend cups/day = <0.0001). More notable reduced risk was seen among women than men (Pinteraction = 0.07). Women who consumed more than three cups of coffee per day were at a 54% lower risk of HCC (HR, 0.46; 95% CI, 0.26–0.81), whereas men had more modest reduced risk of HCC (HR, 0.93; 95% CI, 0.63–1.37). The associations were stronger for caffeinated coffee (HR>3 cups/day vs. non-drinker, 0.71; 95% CI, 0.50–1.01) than decaffeinated coffee (HR, 0.92; 95% CI, 0.55–1.54). There was no association between coffee consumption and ICC.

Conclusions: These findings suggest that, in a U.S. population, coffee consumption is associated with reduced risk of HCC.

Impact: Further research into specific coffee compounds and mechanisms that may account for these associations is needed. Cancer Epidemiol Biomarkers Prev; 24(9); 1398–406. ©2015 AACR.
Data from Do Environmental Factors Modify the Genetic Risk of Prostate Cancer?
Authors: Loeb Stacy , Peskoe Sarah B. , Joshu Corinne E. , Huang Wen-Yi , Hayes Richard B. , Carter H. Ballentine , Isaacs William B. , Platz Elizabeth A.
Published: April 2023

Abstract
Background: Many SNPs influence prostate cancer risk. To what extent genetic risk can be reduced by environmental factors is unknown.

Methods: We evaluated effect modification by environmental factors of the association between susceptibility SNPs and prostate cancer in 1,230 incident prostate cancer cases and 1,361 controls, all white and similar ages, nested in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Trial. Genetic risk scores were calculated as number of risk alleles for 20 validated SNPs. We estimated the association between higher genetic risk (≥12 SNPs) and prostate cancer within environmental factor strata and tested for interaction.

Results: Men with ≥12 risk alleles had 1.98, 2.04, and 1.91 times the odds of total, advanced, and nonadvanced prostate cancer, respectively. These associations were attenuated with the use of selenium supplements, aspirin, ibuprofen, and higher vegetable intake. For selenium, the attenuation was most striking for advanced prostate cancer: compared with <12 alleles and no selenium, the OR for ≥12 alleles was 2.06 [95% confidence interval (CI), 1.67–2.55] in nonusers and 0.99 (0.38–2.58) in users (Pinteraction = 0.031). Aspirin had the most marked attenuation for nonadvanced prostate cancer: compared with <12 alleles and nonusers, the OR for ≥12 alleles was 2.25 (1.69–3.00) in nonusers and 1.70 (1.25–2.32) in users (Pinteraction = 0.009). This pattern was similar for ibuprofen (Pinteraction = 0.023) and vegetables (Pinteraction = 0.010).

Conclusions: This study suggests that selenium supplements may reduce genetic risk of advanced prostate cancer, whereas aspirin, ibuprofen, and vegetables may reduce genetic risk of nonadvanced prostate cancer.

Impact: The effect of genetic factors on prostate cancer risk may vary by lifestyle interventions. Cancer Epidemiol Biomarkers Prev; 24(1); 213–20. ©2014 AACR.
Data from Integrated Genomic Analysis Suggests MLL3 Is a Novel Candidate Susceptibility Gene for Familial Nasopharyngeal Carcinoma
Authors: Sasaki Mark M. , Skol Andrew D. , Bao Riyue , Rhodes Lindsay V. , Chambers Rachelle , Vokes Everett E. , Cohen Ezra E.W. , Onel Kenan
Published: April 2023

Abstract
Background: Little is known about genetic factors associated with nasopharyngeal carcinoma (NPC). To gain insight into NPC etiology, we performed whole exome sequencing on germline and tumor DNA from three closely related family members with NPC.

Methods: The family was ascertained through the Pediatric Familial Cancer Clinic at The University of Chicago (Chicago, IL). The diagnosis of NPC was confirmed pathologically for each individual. For each sample sequenced, 97.3% of the exome was covered at 5×, with an average depth of 44×. Candidate germline and somatic variants associated with NPC were identified and prioritized using a custom pipeline.

Results: We discovered 72 rare deleterious germline variants in 56 genes shared by all three individuals. Of these, only three are in previously identified NPC-associated genes, all of which are located within MLL3, a gene known to be somatically altered in NPC. One variant introduces an early stop codon in MLL3, which predicts complete loss-of-function. Tumor DNA analysis revealed somatic mutations and Epstein–Barr virus (EBV) integration events; none, however, were shared among all three individuals.

Conclusions: These data suggest that inherited mutations in MLL3 may have predisposed these three individuals from a single family to develop NPC, and may cooperate with individually acquired somatic mutations or EBV integration events in NPC etiology.

Impact: Our finding is the first instance of a plausible candidate high penetrance inherited mutation predisposing to NPC. Cancer Epidemiol Biomarkers Prev; 24(8); 1222–8. ©2015 AACR.
Data from Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States
Authors: Rivera Andrew , Nan Hongmei , Li Tricia , Qureshi Abrar , Cho Eunyoung
Published: April 2023

Abstract
Background: Alcohol consumption is associated with increased risk of numerous cancers, but existing evidence for an association with melanoma is equivocal. No study has evaluated the association with different anatomic locations of melanoma.

Methods: We used data from three large prospective cohort studies to investigate whether alcohol intake was associated with risk of melanoma. Alcohol intake was assessed repeatedly by food-frequency questionnaires. A Cox proportional hazards model was used to calculate multivariate-adjusted hazard ratios (HRs).

Results: A total of 1,374 cases of invasive melanoma were documented during 3,855,706 person-years of follow-up. There was an association between higher alcohol intake and incidence of invasive melanoma (pooled multivariate HR 1.14 [95% confidence interval (CI), 1.00–1.29] per drink/day; Ptrend = 0.04). Among alcoholic beverages, white wine consumption was associated with an increased risk of melanoma (pooled multivariate HR 1.13 [95% CI, 1.04–1.24] per drink/day; Ptrend <0.01) after adjusting for other alcoholic beverages. The association between alcohol consumption and melanoma risk was stronger for melanoma in relatively UV-spared sites (trunk) versus more UV-exposed sites (head, neck, or extremities). Compared with nondrinkers, the pooled multivariate-adjusted HRs for ≥20 g/day of alcohol were 1.02 (95% CI, 0.64–1.62; Ptrend = 0.25) for melanomas of the head, neck, and extremities and 1.73 (95% CI, 1.25–2.38; Ptrend = 0.02) for melanomas of the trunk.

Conclusions: Alcohol intake was associated with a modest increase in the risk of melanoma, particularly in UV-protected sites.

Impact: These findings further support American Cancer Society Guidelines for Cancer Prevention to limit alcohol intake. Cancer Epidemiol Biomarkers Prev; 25(12); 1550–8. ©2016 AACR.
Data from EGFR Mutation Status and First-Line Treatment in Patients with Stage III/IV Non–Small Cell Lung Cancer in Germany: An Observational Study
Authors: Schuette Wolfgang , Schirmacher Peter , Eberhardt Wilfried Ernst Erich , Fischer Juergen R. , von der Schulenburg J.-Matthias Graf , Mezger Joerg , Schumann Christian , Serke Monika , Zaun Silke , Dietel Manfred , Thomas Michael
Published: April 2023

Abstract
Introduction: EGFR mutations confer sensitivity to EGFR tyrosine kinase inhibitors (TKI) in advanced non–small cell lung cancer (NSCLC). We investigated the clinicopathologic characteristics associated with EGFR mutations and their impact on real-world treatment decisions and outcomes in Caucasian patients with advanced NSCLC.

Methods: REASON (NCT00997230) was a noninterventional multicenter study in patients (≥18 years) with stage IIIb/IV NSCLC, who were candidates for EGFR mutation testing and first-line systemic treatment, but not eligible for surgery or radiotherapy. Patients were followed up according to normal clinical practice and assessed for primary (correlation of mutation status with baseline characteristics) and secondary endpoints (first-line treatment decision).

Results: Baseline data were obtained for 4,200 patients; 4,196 fulfilled the inclusion criteria; EGFR mutations were detected in 431 patients; no EGFR mutations were detected in 3,590 patients; mutation status was not evaluable in 175 patients. In multivariate analysis, the odds of EGFR mutations were significantly higher (P < 0.0001) in females versus males (odds ratio: 1.85; 95% confidence interval, 1.48–2.32), never-smokers versus smokers (3.64; 2.91–4.56), and patients with adenocarcinoma versus other histologic subtypes (2.94; 2.17–4.08). The most commonly prescribed first-line systemic treatments were: EGFR-TKIs in EGFR mutation–positive NSCLC (56.6%) and combination chemotherapy in EGFR mutation–negative NSCLC (78.5%).

Conclusions: This represents the largest dataset for EGFR mutations in Caucasian patients and shows EGFR mutations to be most prevalent in females with adenocarcinoma who had never smoked.

Impact: These findings add to our understanding of the prognostic and predictive factors of NSCLC, supporting future improved treatment selection. Cancer Epidemiol Biomarkers Prev; 24(8); 1254–61. ©2015 AACR.
Data from Racial/Ethnic Differences in the Impact of Neighborhood Social and Built Environment on Breast Cancer Risk: The Neighborhoods and Breast Cancer Study
Authors: Conroy Shannon M. , Shariff-Marco Salma , Koo Jocelyn , Yang Juan , Keegan Theresa H.M. , Sangaramoorthy Meera , Hertz Andrew , Nelson David O. , Cockburn Myles , Satariano William A. , Yen Irene H. , Ponce Ninez A. , John Esther M. , Gomez Scarlett Lin
Published: April 2023

Abstract
Background: Neighborhood socioeconomic status (nSES) has been found to be associated with breast cancer risk. It remains unclear whether this association applies across racial/ethnic groups independent of individual-level factors and is attributable to other neighborhood characteristics.

Methods: We examined the independent and joint associations of education and nSES with odds of breast cancer. Residential addresses were geocoded for 2,838 cases and 3,117 controls and linked to nSES and social and built environment characteristics. We estimated ORs and 95% confidence intervals (CI) using multilevel logistic regression controlling for individual-level breast cancer risk factors and assessed the extent to which nSES associations were due to neighborhood characteristics.

Results: Women living in the highest versus lowest nSES quintile had a nearly 2-fold greater odds of breast cancer, with elevated odds (adjusted ORs, 95% CI) for non-Hispanic whites (NHWs; 2.27; 1.45–3.56), African Americans (1.74; 1.07–2.83), U.S.-born Hispanics (1.82; 1.19–2.79), and foreign-born Hispanics (1.83; 1.06–3.17). Considering education and nSES jointly, ORs were increased for low education/high nSES NHWs (1.83; 1.14–2.95), high education/high nSES NHWs (1.64; 1.06–2.54), and high education/high nSES foreign-born Hispanics (2.17; 1.52–3.09) relative to their race/ethnicity/nativity-specific low education/low nSES counterparts. Adjustment for urban and mixed-land use characteristics attenuated the nSES associations for most racial/ethnic/nativity groups except NHWs.

Conclusions: Our study provides empirical evidence for a role of neighborhood environments in breast cancer risk, specifically social and built environment attributes.

Impact: Considering the role of neighborhood characteristics among diverse populations may offer insights to understand racial/ethnic disparities in breast cancer risk. Cancer Epidemiol Biomarkers Prev; 26(4); 541–52. ©2017 AACR.
Data from Longitudinal Changes in Volumetric Breast Density with Tamoxifen and Aromatase Inhibitors
Authors: Engmann Natalie J. , Scott Christopher G. , Jensen Matthew R. , Ma Lin , Brandt Kathleen R. , Mahmoudzadeh Amir Pasha , Malkov Serghei , Whaley Dana H. , Hruska Carrie B. , Wu Fang Fang , Winham Stacey J. , Miglioretti Diana L. , Norman Aaron D. , Heine John J. , Shepherd John , Pankratz V. Shane , Vachon Celine M. , Kerlikowske Karla
Published: April 2023

Abstract
Background: Reductions in breast density with tamoxifen and aromatase inhibitors may be an intermediate marker of treatment response. We compare changes in volumetric breast density among breast cancer cases using tamoxifen or aromatase inhibitors (AI) to untreated women without breast cancer.

Methods: Breast cancer cases with a digital mammogram prior to diagnosis and after initiation of tamoxifen (n = 366) or AI (n = 403) and a sample of controls (n = 2170) were identified from the Mayo Clinic Mammography Practice and San Francisco Mammography Registry. Volumetric percent density (VPD) and dense breast volume (DV) were measured using Volpara (Matakina Technology) and Quantra (Hologic) software. Linear regression estimated the effect of treatment on annualized changes in density.

Results: Premenopausal women using tamoxifen experienced annualized declines in VPD of 1.17% to 1.70% compared with 0.30% to 0.56% for controls and declines in DV of 7.43 to 15.13 cm3 compared with 0.28 to 0.63 cm3 in controls, for Volpara and Quantra, respectively. The greatest reductions were observed among women with ≥10% baseline density. Postmenopausal AI users had greater declines in VPD than controls (Volpara P = 0.02; Quantra P = 0.03), and reductions were greatest among women with ≥10% baseline density. Declines in VPD among postmenopausal women using tamoxifen were only statistically greater than controls when measured with Quantra.

Conclusions: Automated software can detect volumetric breast density changes among women on tamoxifen and AI.

Impact: If declines in volumetric density predict breast cancer outcomes, these measures may be used as interim prognostic indicators. Cancer Epidemiol Biomarkers Prev; 26(6); 930–7. ©2017 AACR.
Data from Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity
Authors: Jansen Rick J. , Argos Maria , Tong Lin , Li Jiabei , Rakibuz-Zaman Muhammad , Islam Md. Tariqul , Slavkovich Vesna , Ahmed Alauddin , Navas-Acien Ana , Parvez Faruque , Chen Yu , Gamble Mary V. , Graziano Joseph H. , Pierce Brandon L. , Ahsan Habibul
Published: April 2023

Abstract
Background: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine relative to their sum (iAs%, MMA%, and DMA%) varies across individuals, reflecting differences in arsenic metabolism capacity.

Methods: The association of arsenic metabolism phenotypes with participant characteristics and arsenical skin lesions was characterized among 4,794 participants in the Health Effects of Arsenic Longitudinal Study (Araihazar, Bangladesh). Metabolism phenotypes include those obtained from principal component (PC) analysis of arsenic species.

Results: Two independent PCs were identified: PC1 appears to represent capacity to produce DMA (second methylation step), and PC2 appears to represent capacity to convert iAs to MMA (first methylation step). PC1 was positively associated (P <0.05) with age, female sex, and BMI, while negatively associated with smoking, arsenic exposure, education, and land ownership. PC2 was positively associated with age and education but negatively associated with female sex and BMI. PC2 was positively associated with skin lesion status, while PC1 was not. 10q24.32/AS3MT region polymorphisms were strongly associated with PC1, but not PC2. Patterns of association for most variables were similar for PC1 and DMA%, and for PC2 and MMA% with the exception of arsenic exposure and SNP associations.

Conclusions: Two distinct arsenic metabolism phenotypes show unique associations with age, sex, BMI, 10q24.32 polymorphisms, and skin lesions.

Impact: This work enhances our understanding of arsenic metabolism kinetics and toxicity risk profiles. Cancer Epidemiol Biomarkers Prev; 25(2); 381–90. ©2015 AACR.
Data from Folate Pathway Gene Polymorphisms, Maternal Folic Acid Use, and Risk of Childhood Acute Lymphoblastic Leukemia
Authors: Milne Elizabeth , Greenop Kathryn R. , Scott Rodney J. , Haber Michelle , Norris Murray D. , Attia John , Jamieson Sarra E. , Miller Margaret , Bower Carol , Bailey Helen D. , Dawson Somer , McCowage Geoffrey B. , de Klerk Nicholas H. , van Bockxmeer Frank M. , Armstrong Bruce K.
Published: April 2023

Abstract
Background: Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukemia (ALL). We investigated associations between ALL risk and folate pathway gene polymorphisms, and their modification by maternal folic acid supplements, in a population-based case–control study (2003–2007).

Methods: All Australian pediatric oncology centers provided cases; controls were recruited by national random digit dialing. Data from 392 cases and 535 controls were included. Seven folate pathway gene polymorphisms (MTHFR 677C>T, MTHFR 1298A>C, MTRR 66A>G, MTR 2756 A>G, MTR 5049 C>A, CBS 844 Ins68, and CBS 2199 T>C) were genotyped in children and their parents. Information on prepregnancy maternal folic acid supplement use was collected. ORs were estimated with unconditional logistic regression adjusted for frequency-matched variables and potential confounders. Case–parent trios were also analyzed.

Results: There was some evidence of a reduced risk of ALL among children who had, or whose father had, the MTRR 66GG genotype: ORs 0.60 [95% confidence interval (CI) 0.39–0.91] and 0.64 (95% CI, 0.40–1.03), respectively. The ORs for paternal MTHFR 677CT and TT genotypes were 1.41 (95% CI, 1.02–1.93) and 1.81 (95% CI, 1.06–3.07). ORs varied little by maternal folic acid supplementation.

Conclusions: Some folate pathway gene polymorphisms in the child or a parent may influence ALL risk. While biologically plausible, underlying mechanisms for these associations need further elucidation.

Impact: Folate pathway polymorphisms may be related to risk of childhood ALL, but larger studies are needed for conclusive results. Cancer Epidemiol Biomarkers Prev; 24(1); 48–56. ©2014 AACR.
Data from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
Authors: Marks Morgan A. , Chaturvedi Anil K. , Kelsey Karl , Straif Kurt , Berthiller Julien , Schwartz Stephen M. , Smith Elaine , Wyss Annah , Brennan Paul , Olshan Andrew F. , Wei Qingyi , Sturgis Erich M. , Zhang Zuo-Feng , Morgenstern Hal , Muscat Joshua , Lazarus Philip , McClean Michael , Chen Chu , Vaughan Thomas L. , Wunsch-Filho Victor , Curado Maria Paula , Koifman Sergio , Matos Elena , Menezes Ana , Daudt Alexander W. , Fernandez Leticia , Posner Marshall , Boffetta Paolo , Lee Yuan-Chin Amy , Hashibe Mia , D'Souza Gypsyamber
Published: April 2023

Abstract
Background: The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950.

Methods: A pooled analysis was conducted comprising individual-level data from nine case–control studies from the United States and Latin America in the INHANCE consortium. Self-reported information on marijuana smoking, demographic, and behavioral factors was obtained from 1,921 oropharyngeal cases, 356 oral tongue cases, and 7,639 controls.

Results: Compared with never marijuana smokers, ever marijuana smokers had an elevated risk of oropharyngeal [adjusted OR (aOR), 1.24; 95% confidence interval (CI): 1.06–1.47] and a reduced risk of oral tongue cancer (aOR, 0.47; 95% CI, 0.29, 0.75). The risk of oropharyngeal cancer remained elevated among never tobacco and alcohol users. The risk of oral tongue cancer was reduced among never users of tobacco and alcohol. Sensitivity analysis adjusting for potential confounding by HPV exposure attenuated the association of marijuana use with oropharyngeal cancer (aOR, 0.99; 95% CI, 0.71–1.25), but had no effect on the oral tongue cancer association.

Conclusions: These results suggest that the association of marijuana use with head and neck carcinoma may differ by tumor site.

Impact: The associations of marijuana use with oropharyngeal and oral tongue cancer are consistent with both possible pro- and anticarcinogenic effects of cannabinoids. Additional work is needed to rule out various sources of bias, including residual confounding by HPV infection and misclassification of marijuana exposure. Cancer Epidemiol Biomarkers Prev; 23(1); 160–71. ©2013 AACR.
Data from Prevalence, Long-term Development, and Predictors of Psychosocial Consequences of False-Positive Mammography among Women Attending Population-Based Screening
Authors: Bolejko Anetta , Hagell Peter , Wann-Hansson Christine , Zackrisson Sophia
Published: April 2023

Abstract
Background: Cancer screening aims to detect cancer at an asymptomatic stage, although side effects from screening also occur. We investigated the prevalence, longitudinal development, and predictors of psychosocial consequences of false-positive breast cancer screening.

Methods: Three hundred ninety-nine women with false-positive screening mammography responded to the Consequences of Screening–Breast Cancer (COS-BC) questionnaire immediately after a negative diagnosis (free from breast cancer) following recall examination(s) (baseline), and 6 and 12 months later. Age-matched controls (n = 499) with a negative mammogram responded to the COS-BC at the same occasions. Five COS-BC scales (Sense of dejection, Anxiety, Behavioral, Sleep, and Existential values) were used as outcome measures.

Results: Women with false-positive mammography had consistently higher prevalence of all five consequences compared with controls (P < 0.001). The prevalences decreased between baseline and 6 months (P < 0.001) but were stable between 6 and 12 months (P ≥ 0.136). Early recall profoundly predicted long-term consequences for all five outcomes (OR, 3.05–10.31), along with dissatisfaction with information at recall (OR, 2.28–2.56), being foreign-born (OR, 2.35–3.71), and lack of social support (OR, 1.13–1.25).

Conclusion: This 1-year longitudinal study shows that women experience psychosocial consequences of false-positive screening mammography. Early recall should be performed cautiously, and provision of information as well as social support may reduce psychosocial consequences.

Impact: Although delivery of population-based screening reduces breast cancer mortality, it also raises the issue of its impact on the psychosocial well-being of healthy women. Our findings identify predictors that can be targeted in future efforts to reduce the side effects of mammographic screening. Cancer Epidemiol Biomarkers Prev; 24(9); 1388–97. ©2015 AACR.
Data from Association of Parity and Time since Last Birth with Breast Cancer Prognosis by Intrinsic Subtype
Authors: Sun Xuezheng , Nichols Hazel B. , Tse Chiu-Kit , Bell Mary B. , Robinson Whitney R. , Sherman Mark E. , Olshan Andrew F. , Troester Melissa A.
Published: April 2023

Abstract
Background: Parity and time since last birth influence breast cancer risk and vary by intrinsic tumor subtype, but the independent effects of these factors on prognosis have received limited attention.

Methods: Study participants were 1,140 invasive breast cancer patients from phases I and II of the population-based Carolina Breast Cancer Study, with tissue blocks available for subtyping using immunohistochemical markers. Breast cancer risk factors, including pregnancy history, were collected via in-person interviews administered shortly after diagnosis. Vital status was determined using the National Death Index. The association of parity and birth recency with breast cancer–specific and overall survival was assessed using Cox proportional hazards models.

Results: During follow-up (median = 13.5 years), 450 patients died, 61% due to breast cancer (n = 276). High parity (3+ births) and recent birth (<5 years before diagnosis) were positively associated with breast cancer–specific mortality, independent of age, race, and selected socioeconomic factors [parity, reference = nulliparous, adjusted HR = 1.76; 95% confidence interval (CI) = 1.13–2.73; birth recency, reference = 10+ years, adjusted HR = 1.29; 95% CI, 0.79–2.11]. The associations were stronger among patients with luminal tumors and those surviving longer than 5 years.

Conclusions: Parity and recent birth are associated with worse survival among breast cancer patients, particularly among luminal breast cancers and long-term survivors.

Impact: The biologic effects of parity and birth recency may extend from etiology to tumor promotion and progression. Cancer Epidemiol Biomarkers Prev; 25(1); 60–67. ©2015 AACR.
Data from A Genome-Wide Association Study of Renal Cell Carcinoma among African Americans
Authors: Purdue Mark P. , Ye Yuanqing , Wang Zhaoming , Colt Joanne S. , Schwartz Kendra L. , Davis Faith G. , Rothman Nathaniel , Chow Wong-Ho , Wu Xifeng , Chanock Stephen J.
Published: April 2023

Abstract
Genome-wide association studies (GWAS) of renal cell carcinoma (RCC) in populations of European ancestry have identified four susceptibility loci. No GWAS has been conducted among African Americans (AA), who experience a higher incidence of RCC. We conducted a GWAS in which we analyzed 1,136,723 common single-nucleotide polymorphisms (SNP) among 255 cases and 375 controls of African ancestry, and further investigated 16 SNPs in a replication set (140 cases and 543 controls). The 12p11.23 variant rs10771279, located 77 kb from the European-ancestry RCC marker rs718314, was associated with RCC risk in the GWAS (P = 1.2 × 10−7) but did not replicate (P = 0.99). Consistent with European-ancestry findings, the A allele of rs7105934 on 11q13.3 was associated with decreased risk [OR, 0.76, 95% confidence interval (CI), 0.64–0.91; P = 0.0022]. The frequency of this allele was higher than that observed in the European-ancestry GWAS (0.56 and 0.07, respectively, among controls). The rs7105934 association was stronger for clear cell RCC (ccRCC: OR, 0.56; P = 7.4 × 10−7) and absent for cases of other or unknown histology (OR, 1.02; P = 0.86). Analyses of rs7105934 by subtype among European-ancestry participants from these studies yielded similar findings (ORs 0.69 and 0.92, respectively). This study provides, to our knowledge, the first evidence that rs7105934 is an RCC susceptibility locus among AAs. Our finding that the association with this SNP may be specific to clear-cell RCC is novel and requires additional investigation. Additional investigation of rs10771279 and other suggestive GWAS findings is also needed. Cancer Epidemiol Biomarkers Prev; 23(1); 209–14. ©2013 AACR.
Data from A Pooled Analysis of 15 Prospective Cohort Studies on the Association between Fruit, Vegetable, and Mature Bean Consumption and Risk of Prostate Cancer
Authors: Petimar Joshua , Wilson Kathryn M. , Wu Kana , Wang Molin , Albanes Demetrius , van den Brandt Piet A. , Cook Michael B. , Giles Graham G. , Giovannucci Edward L. , Goodman Gary E. , Goodman Phyllis J. , Håkansson Niclas , Helzlsouer Kathy , Key Timothy J. , Kolonel Laurence N. , Liao Linda M. , Männistö Satu , McCullough Marjorie L. , Milne Roger L. , Neuhouser Marian L. , Park Yikyung , Platz Elizabeth A. , Riboli Elio , Sawada Norie , Schenk Jeannette M. , Tsugane Shoichiro , Verhage Bas , Wang Ying , Wilkens Lynne R. , Wolk Alicja , Ziegler Regina G. , Smith-Warner Stephanie A.
Published: April 2023

Abstract
Background: Relationships between fruit, vegetable, and mature bean consumption and prostate cancer risk are unclear.

Methods: We examined associations between fruit and vegetable groups, specific fruits and vegetables, and mature bean consumption and prostate cancer risk overall, by stage and grade, and for prostate cancer mortality in a pooled analysis of 15 prospective cohorts, including 52,680 total cases and 3,205 prostate cancer–related deaths among 842,149 men. Diet was measured by a food frequency questionnaire or similar instrument at baseline. We calculated study-specific relative risks using Cox proportional hazards regression, and then pooled these estimates using a random effects model.

Results: We did not observe any statistically significant associations for advanced prostate cancer or prostate cancer mortality with any food group (including total fruits and vegetables, total fruits, total vegetables, fruit and vegetable juice, cruciferous vegetables, and tomato products), nor specific fruit and vegetables. In addition, we observed few statistically significant results for other prostate cancer outcomes. Pooled multivariable relative risks comparing the highest versus lowest quantiles across all fruit and vegetable exposures and prostate cancer outcomes ranged from 0.89 to 1.09. There was no evidence of effect modification for any association by age or body mass index.

Conclusions: Results from this large, international, pooled analysis do not support a strong role of collective groupings of fruits, vegetables, or mature beans in prostate cancer.

Impact: Further investigation of other dietary exposures, especially indicators of bioavailable nutrient intake or specific phytochemicals, should be considered for prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 26(8); 1276–87. ©2017 AACR.
Data from Interactions between Ultraviolet Light and MC1R and OCA2 Variants Are Determinants of Childhood Nevus and Freckle Phenotypes
Authors: Barón Anna E. , Asdigian Nancy L. , Gonzalez Victoria , Aalborg Jenny , Terzian Tamara , Stiegmann Regan A. , Torchia Enrique C. , Berwick Marianne , Dellavalle Robert P. , Morelli Joseph G. , Mokrohisky Stefan T. , Crane Lori A. , Box Neil F.
Published: April 2023

Abstract
Background: Melanocytic nevi (moles) and freckles are well known biomarkers of melanoma risk, and they are influenced by similar UV light exposures and genetic susceptibilities to those that increase melanoma risk. Nevertheless, the selective interactions between UV exposures and nevus and freckling genes remain largely undescribed.

Methods: We conducted a longitudinal study from ages 6 through 10 years in 477 Colorado children who had annual information collected for sun exposure, sun protection behaviors, and full body skin exams. MC1R and HERC2/OCA2 rs12913832 were genotyped and linear mixed models were used to identify main and interaction effects.

Results: All measures of sun exposure (chronic, sunburns, and waterside vacations) contributed to total nevus counts, and cumulative chronic exposure acted as the major driver of nevus development. Waterside vacations strongly increased total nevus counts in children with rs12913832 blue eye color alleles and facial freckling scores in those with MC1R red hair color variants. Sunburns increased the numbers of larger nevi (≥2 mm) in subjects with certain MC1R and rs12913832 genotypes.

Conclusions: Complex interactions between different UV exposure profiles and genotype combinations determine nevus numbers and size, and the degree of facial freckling.

Impact: Our findings emphasize the importance of implementing sun-protective behavior in childhood regardless of genetic make-up, although children with particular genetic variants may benefit from specifically targeted preventive measures to counteract their inherent risk of melanoma. Moreover, we demonstrate, for the first time, that longitudinal studies are a highly powered tool to uncover new gene–environment interactions that increase cancer risk. Cancer Epidemiol Biomarkers Prev; 23(12); 2829–39. ©2014 AACR.
Data from The Impact of DNA Input Amount and DNA Source on the Performance of Whole-Exome Sequencing in Cancer Epidemiology
Authors: Zhu Qianqian , Hu Qiang , Shepherd Lori , Wang Jianmin , Wei Lei , Morrison Carl D. , Conroy Jeffrey M. , Glenn Sean T. , Davis Warren , Kwan Marilyn L. , Ergas Isaac J. , Roh Janise M. , Kushi Lawrence H. , Ambrosone Christine B. , Liu Song , Yao Song
Published: April 2023

Abstract
Background: Whole-exome sequencing (WES) has recently emerged as an appealing approach to systematically study coding variants. However, the requirement for a large amount of high-quality DNA poses a barrier that may limit its application in large cancer epidemiologic studies. We evaluated the performance of WES with low input amount and saliva DNA as an alternative source material.

Methods: Five breast cancer patients were randomly selected from the Pathways Study. From each patient, four samples, including 3 μg, 1 μg, and 0.2 μg blood DNA and 1 μg saliva DNA, were aliquoted for library preparation using the Agilent SureSelect Kit and sequencing using Illumina HiSeq2500. Quality metrics of sequencing and variant calling, as well as concordance of variant calls from the whole exome and 21 known breast cancer genes, were assessed by input amount and DNA source.

Results: There was little difference by input amount or DNA source on the quality of sequencing and variant calling. The concordance rate was about 98% for single-nucleotide variant calls and 83% to 86% for short insertion/deletion calls. For the 21 known breast cancer genes, WES based on low input amount and saliva DNA identified the same set variants in samples from a same patient.

Conclusions: Low DNA input amount, as well as saliva DNA, can be used to generate WES data of satisfactory quality.

Impact: Our findings support the expansion of WES applications in cancer epidemiologic studies where only low DNA amount or saliva samples are available. Cancer Epidemiol Biomarkers Prev; 24(8); 1207–13. ©2015 AACR.
Supplementary Movie S8 from Development and Characterization of a Novel In vivo Model of Carcinoid Syndrome
Authors: Jackson Lindsey N. , Chen L. Andy , Larson Shawn D. , Silva Scott R. , Rychahou Piotr G. , Boor Paul J. , Li Jing , DeFreitas Gilberto , Stafford W. Lane , Townsend Courtney M. , Evers B. Mark
Published: April 2023

Supplementary Movie S8 from Development and Characterization of a Novel In vivo Model of Carcinoid Syndrome
Supplementary Data from A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors
Authors: Cohen Roger B. , Jones Suzanne F. , Aggarwal Charu , von Mehren Margaret , Cheng Jonathan , Spigel David R. , Greco F. Anthony , Mariani Mariangela , Rocchetti Maurizio , Ceruti Roberta , Comis Silvia , Laffranchi Bernard , Moll Jurgen , Burris Howard A.
Published: April 2023

Supplementary Data from A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors
Supplementary Table S1 from Endometrial Profile of Tamoxifen and Low-Dose Estradiol Combination Therapy
Authors: Wood Charles E. , Kaplan Jay R. , Fontenot M. Babette , Williams J. Koudy , Cline J. Mark
Published: April 2023

Supplementary Table S1 from Endometrial Profile of Tamoxifen and Low-Dose Estradiol Combination Therapy
Supplementary Table S1 from Targeting Akt3 Signaling in Malignant Melanoma Using Isoselenocyanates
Authors: Sharma Arati , Sharma Arun K. , Madhunapantula SubbaRao V. , Desai Dhimant , Huh Sung Jin , Mosca Paul , Amin Shantu , Robertson Gavin P.
Published: April 2023

Supplementary Table S1 from Targeting Akt3 Signaling in Malignant Melanoma Using Isoselenocyanates
Supplementary Figure 5 from Omental Adipose Tissue–Derived Stromal Cells Promote Vascularization and Growth of Endometrial Tumors
Authors: Klopp Ann H. , Zhang Yan , Solley Travis , Amaya-Manzanares Felipe , Marini Frank , Andreeff Michael , Debeb Bisrat , Woodward Wendy , Schmandt Rosemarie , Broaddus Russell , Lu Karen , Kolonin Mikhail G.
Published: April 2023

PDF file - 813K, Secretion of angiogenic cytokines by O-ASC, BM-MSC, SC-ASC and WI38.
Supplementary Table 1 from Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803
Authors: Ogino Shuji , Shima Kaori , Meyerhardt Jeffrey A. , McCleary Nadine J. , Ng Kimmie , Hollis Donna , Saltz Leonard B. , Mayer Robert J. , Schaefer Paul , Whittom Renaud , Hantel Alexander , Benson Al B. , Spiegelman Donna , Goldberg Richard M. , Bertagnolli Monica M. , Fuchs Charles S.
Published: April 2023

PDF file - 40K
Supplementary Tables 1-3, Figures 1-2 and Methods from BCR–ABL Transcript Dynamics Support the Hypothesis That Leukemic Stem Cells Are Reduced during Imatinib Treatment
Authors: Stein Andrew M. , Bottino Dean , Modur Vijay , Branford Susan , Kaeda Jaspal , Goldman John M. , Hughes Timothy P. , Radich Jerald P. , Hochhaus Andreas
Published: April 2023

PDF file - 325K
CCR Translation for This Article from BCR–ABL Transcript Dynamics Support the Hypothesis That Leukemic Stem Cells Are Reduced during Imatinib Treatment
Authors: Stein Andrew M. , Bottino Dean , Modur Vijay , Branford Susan , Kaeda Jaspal , Goldman John M. , Hughes Timothy P. , Radich Jerald P. , Hochhaus Andreas
Published: April 2023

CCR Translation for This Article from BCR–ABL Transcript Dynamics Support the Hypothesis That Leukemic Stem Cells Are Reduced during Imatinib Treatment
Supplementary Table Legend 1 from The HDAC Inhibitor LBH589 Enhances the Antimyeloma Effects of the IGF-1RTK Inhibitor Picropodophyllin
Authors: Lemaire Miguel , Fristedt Charlotte , Agarwal Prasoon , Menu Eline , Van Valckenborgh Els , De Bruyne Elke , Österborg Anders , Atadja Peter , Larsson Olle , Axelson Magnus , Van Camp Ben , Jernberg-Wiklund Helena , Vanderkerken Karin
Published: April 2023

PDF file - 60K
Supplementary Figure 1 from Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients
Authors: Ciarimboli Giuliano , Lancaster Cynthia S. , Schlatter Eberhard , Franke Ryan M. , Sprowl Jason A. , Pavenstädt Hermann , Massmann Vivian , Guckel Denise , Mathijssen Ron H. J. , Yang Wenjian , Pui Ching-Hon , Relling Mary V. , Herrmann Edwin , Sparreboom Alex
Published: April 2023

PDF file - 52K
Supplementary Table 4 from High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma
Authors: Schulte Johannes H. , Bachmann Hagen S. , Brockmeyer Bent , DePreter Katleen , Oberthür André , Ackermann Sandra , Kahlert Yvonne , Pajtler Kristian , Theissen Jessica , Westermann Frank , Vandesompele Jo , Speleman Frank , Berthold Frank , Eggert Angelika , Brors Benedikt , Hero Barbara , Schramm Alexander , Fischer Matthias
Published: April 2023

Supplementary Table 4 from High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma
Supplementary Table 3 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
Authors: Herzog Amanda , Bian Yansong , Vander Broek Robert , Hall Bradford , Coupar Jamie , Cheng Hui , Sowers Anastasia L. , Cook John D. , Mitchell James B. , Chen Zhong , Kulkarni Ashok B. , Van Waes Carter
Published: April 2023

PDF file - 184K, TGFBR mutations.
Supplementary Figure 4 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
Authors: Herzog Amanda , Bian Yansong , Vander Broek Robert , Hall Bradford , Coupar Jamie , Cheng Hui , Sowers Anastasia L. , Cook John D. , Mitchell James B. , Chen Zhong , Kulkarni Ashok B. , Van Waes Carter
Published: April 2023

PDF file - 1792K, DNA flow cytometry in 5 lines.
Supplementary Figure S7 from The IL-18 Antagonist IL-18–Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment
Authors: Carbotti Grazia , Barisione Gaia , Orengo Anna Maria , Brizzolara Antonella , Airoldi Irma , Bagnoli Marina , Pinciroli Patrizia , Mezzanzanica Delia , Centurioni Maria Grazia , Fabbi Marina , Ferrini Silvano
Published: April 2023

Supplementary Figure S7 - PDF file 603K, Immunochemical analysis of EBI3 expression in EOC. Immunochemistry with an anti-EBI3 Ab shows EBI3 expression predominantly by reactive cells in both ascites (A) and tumor tissues (B). Arrows indicate examples of tumor cell nests. The sections were observed with a Nikon Eclipse 80i light microscope equipped with a color camera imaging head, using a 40x objective. Bar=100�m
Supplementary Figure S6 from The IL-18 Antagonist IL-18–Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment
Authors: Carbotti Grazia , Barisione Gaia , Orengo Anna Maria , Brizzolara Antonella , Airoldi Irma , Bagnoli Marina , Pinciroli Patrizia , Mezzanzanica Delia , Centurioni Maria Grazia , Fabbi Marina , Ferrini Silvano
Published: April 2023

Supplementary Figure S6 - PDF file 185K, A: Analysis of the correlation between IL18BP and EBI3 mRNA levels in high grade (Type II) tumors in two microarray datasets of EOC. A significant correlation was found between EBI3 and IL18BP in both datasets, suggesting a relationship between the expression of EBI3 and IL18BP mRNA in EOC cell primary tumors. Pearson's correlation coefficients are shown (r). Lines represent the best fit linear regression analysis with the 95% Confidence Interval. B: Association between different EBI3 mRNA expression levels and Progression Free Survival (PFS) in Type II EOC of the Tothill microarray dataset. High EBI3 mRNA levels are associated to a shorter PFS time. Median PFS was 13 months for EBI3 levels higher than third quartile versus 21 months for EBI3 levels lower than first quartile (P=0.016). Solid line: cases with EBI3 levels lower than first quartile (n.52). Dashed line: cases with EBI3 levels higher than third quartile (n.49). P values were determined using log-rank test.
Supplementary Figure S2 from The IL-18 Antagonist IL-18–Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment
Authors: Carbotti Grazia , Barisione Gaia , Orengo Anna Maria , Brizzolara Antonella , Airoldi Irma , Bagnoli Marina , Pinciroli Patrizia , Mezzanzanica Delia , Centurioni Maria Grazia , Fabbi Marina , Ferrini Silvano
Published: April 2023

Supplementary Figure S2 - PDF file 2513K, A and B: Analysis of the correlation between IL-18 and IL-18BP protein levels in EOC sera (n. 47) (A) and ascites (n. 17) (B). No significant correlation (P=ns) was found by Pearson's test. C: Analysis of the correlation between IL18 and IL-18BP protein levels and IFN-? in the ascites of 15 EOC patients. IFN-? levels are low to undetectable and show no correlation with IL-18 or IL-18BP levels (P=ns). Pearson's correlation coefficients are shown (r). Lines represent the best-fit linear regression analysis with the 95% Confidence Interval
Supplementary Figure S1 from The IL-18 Antagonist IL-18–Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment
Authors: Carbotti Grazia , Barisione Gaia , Orengo Anna Maria , Brizzolara Antonella , Airoldi Irma , Bagnoli Marina , Pinciroli Patrizia , Mezzanzanica Delia , Centurioni Maria Grazia , Fabbi Marina , Ferrini Silvano
Published: April 2023

Supplementary Figure S1 - PDF file 744K, Receiver Operating Characteristic (ROC) curve for IL-18BP serum levels at diagnosis in patients with all types and stages of ovarian tumors (malignant n. 48 versus normal controls n. 13): the area under the curve (AUC) value is significant with the 95% confidence interval indicated in parentheses. SE=standard error
Supplementary Figure 2 from Sequence Dependence of MEK Inhibitor AZD6244 Combined with Gemcitabine for the Treatment of Biliary Cancer
Authors: Xu Junyao , Knox Jennifer J. , Ibrahimov Emin , Chen Eric , Serra Stefano , Tsao Ming , Cao Pinjiang , Vines Douglass , Green David E. , Metran-Nascente Cristiane , McNamara Mairead G. , Hedley David W.
Published: April 2023

PDF file - 66K, Effect of AZD6244 on cell cycle phase distribution and DNA synthesis of human biliary cancer cells
Related Article from Aflibercept in Pediatric Solid Tumors: Moving Beyond the Trap
Authors: Chau Cindy H. , Figg William D.
Published: April 2023

Related Article from Aflibercept in Pediatric Solid Tumors: Moving Beyond the Trap
Supplementary Figure 4 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows In Vivo Antitumor Activity
Authors: Yun Seong-Hoon , Park Eun-Seon , Shin Sung-Won , Na Yong-Woo , Han Jin-Yeong , Jeong Jin-Sook , Shastina Valeria V. , Stonik Valentin A. , Park Joo-In , Kwak Jong-Young
Published: April 2023

PDF file - 1MB, Depletion of GSH and production of ROS may contribute to STC-induced apoptosis in human leukemic and colorectal cancer cells. (A) HL-60, K562, HT-29, and SNU-C4 cells were treated with STC (0.3, 0.5 muM) or STC (1.0, 1.5 muM) for 2 h, 2h, 24 h, and 24 h, respectively, in the presence or absence of GSH, NAC, catalase, or BSO and measured intracellular GSH content using glutathione assay kit. **, P < 0.01; ***, P < 0.001. (B) HL-60, K562, HT-29, and SNU-C4 cells (1 �~ 105 cells/ well) were incubated with STC in the presence or absence of GSH, NAC, catalase, or BSO for 6 h, 6 h, 48 h, and 48 h, respectively. After treatment for the indicated times, the percentage of apoptotic cells was determined by annexin V-FITC/PI staining as described in the Materials and Methods section. Data show the mean �} SD of 3 independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001. (C) HL-60, K562, HT-29, and SNU-C4 cells (1 �~ 105 cells/ well) were incubated with STC in the presence or absence of GSH, NAC, catalase, or BSO for 2 h, 2 h, 24 h, and 24 h, respectively, after which they were labeled with an oxidant-sensitive dye (DCF-DA) and analyzed by flow cytometry. **, P < 0.01; ***, P < 0.001, yielding significantly lower values than those obtained for cells treated with STC in the absence of GSH, NAC, or catalase.