bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Technique to Assess Rotational Deformities in Lower Extremities
Authors: Bakhshayesh Peyman , Ihediwa Ugwunna , Sandher Sukha , Vris Alexandros , Heidari Nima , Enocson Anders
Published: December 2020

Introduction: Rotational deformities following IM nailing of tibia has a reported incidence of as high as 20%. Common techniques to measure deformities following IM nailing of tibia are either based on clinical assessment, plain X-rays or CT-scan comparing the treated leg with the uninjured contralateral side. All these techniques are based on examiners manual calculation inherently subject to bias. Following our previous rigorous motion analysis and symmetry studies on hemi pelvises, femurs and orthopaedic implants, we aimed to introduce a novel fully digital technique to measure rotational deformities in the lower legs.Material and Methods: Following formal institutional approval from the Imperial College, CT images of 10 pairs of human lower legs were retrieved. Images were anonymized and uploaded to a research server. Three dimensional CT images of the lower legs were bilaterally reconstructed. The mirrored images of the left side were merged with the right side proximally as stationary and distally as moving objects. Discrepancies in translation and rotation were automatically calculated.Results: Our study population had a mean age of 54 ± 20 years. There were six males and four females. We observed a greater variation in translation (mm) of Centre of Mass (COM) in sagittal plane (CI: -2.959--.292) which was also presented as rotational difference alongside the antero-posterior direction or Y axis (CI: .370-1.035). In other word the right lower legs in our study were more likely to be in varus compared to the left side. However, there were no statistically significant differences in coronal or axial planes.Conclusion: Using our proposed fully digital technique we found that lower legs of the human adults were symmetrical in axial and coronal plane. We found sagittal plane differences which need further addressing in future using bigger sample size. Our novel recommended technique is fully digital and commercially available. This new technique can be useful in clinical practice addressing rotational deformities following orthopaedic surgical intervention. This new technique can substitute the previously introduced techniques.
An Internet-Based Emotion Regulation Intervention Versus no Intervention for Nonsuicidal Self-Injury in Adolescents: Study Protocol for a Feasibility Trial
Authors: Morthorst Britt Reuter , Rubæk Lotte , Lindschou Jane , Jakobsen Janus Christian , Gluud Christian Gluud Christian , Bjurebjerg Johan , Hellner Clara , Møhl Bo , Pagsberg Anne Katrine
Published: December 2020

Background: Non-suicidal self-injury (NSSI) has gained increased attention in recent years due to increased prevalence, especially among adolescents. Evidence-based interventions for NSSI are sparse. Emotion regulation individual therapy for adolescents (ERITA) is an online intervention that needs investigation. Non-randomised studies suggest ERITA improves emotion regulations skills and reduces NSSI frequency. Before conducting a large pragmatic randomised clinical trial, we aim to investigate the feasibility of ERITA in Denmark. Methods: A randomised, parallel group feasibility trial comparing ERITA as add on to treatment as usual versus treatment as usual in 30 adolescents age 13-17 years with recurrent NSSI referred to outpatient clinics in The Child and Adolescent Mental Health Services in the Capital Region of Denmark. Feasibility outcomes are 1) completion of follow-up, 2) the fraction of eligible participants who consent to inclusion and randomisation, and 3) compliance with the intervention. Exploratory clinical outcomes such as self-injury frequency and the ability to regulate emotions will be investigated exploratorily. Discussion: Internet-based interventions are assumed to be appealing to adolescents by being easily accessible and easy to navigate by tech natives. Disclosure of self-injury behaviour may be facilitated by an online intervention. The evidence for self-injury specific treatment needs to be extended but prior to a large clinical trial, the feasibility of methods and procedures must be assessed. Trial registration: ClinicalTrials.Gov Identifier: NCT04243603
Case Report 1: NAD+ Oscillation Therapy (NOT) to treat Covid-19 aggravated by poorly controlled Diabetes Melitus Type 2
Authors: Wyk Adriaan Francois van , Verwey Theo
Published: December 2020

We report on a case of a 50 year old diabetic, obese and hypertensive male patient that developed severe disease, was admitted and treated with NAD+ Oscillation Therapy (NOT) and then discharged in a stable condition within 5 days (not requiring home oxygen therapy). In addition to the favourable outcome in regards to severe COVID-19 disease, the patient’s blood glucose levels were better controlled after resolution of COVID-19 and the patient has no apparent post-COVID-19 morbidity, which has been reported in countries across the world.NAD+ Oscillation Therapy is a novel medical treatment developed in South Africa. NAD+ Oscillation Therapy envelops the real time measurement of the NAD+/NADH ratio and modulation of the ratio with the goal of restoration of homeostasis. This supports the primary role of the immune system which is protection and restoration.This case shows a favourable treatment outcome in a high risk patient that developed severe disease. Treatment was initiated early and hospitalization was done before laboratory markers reached critical levels. This case highlights the importance of early treatment initiation, effective patient counselling re home care (recognition of sepsis and respiratory distress), NOT as a realtime treatment method of sepsis and the advantage of NOT as a treatment modality in COVID-19 patient care.
Changes in potential cancer indicator reporting in primary-care during the COVID-19 pandemic
Authors: Scott Lauren J , Murphy Mairead , Price Sarah , Lewis Rhys , Denholm Rachel , Horwood Jeremy , Salisbury Chris
Published: December 2020

Background In March 2020, the World Health Organisation declared COVID-19 a pandemic.Aim To investigate how the pandemic affected presentation to primary-care with features potentially indicating cancer, and explore how reporting differed by patient characteristics and in face-to-face vs. remote consultations.Design and setting Retrospective cohort study in 21 practices in South-West England.Methods Potential cancer indicators were identified using pre-defined code lists for symptoms, signs, test results and diagnoses. Negative binomial regression models compared reporting of potential cancer indicators in April-July 2020 to April-July 2019. Incidence rate ratios (IRRs), 95% confidence intervals (CIs) and p-values are reported.Results During April-July 2019 and 2020, respectively, 152,447/344,184 (44%) and 123,775/350,966 (35%) patients consulted, with 44,662/344,184 (13%) and 29,150/350,966 (8%) reporting a potential cancer indicator (IRR=0.65, 95%CI 0.62-0.68, p<0.001). Reduced indicator reporting was stable across ethnicity, deprivation and shielding status, was greater in children (0-4 years IRR=0.50, 95%CI 0.46-0.55, p<0.001; 5-17 years IRR=0.45, 95%CI 0.41-0.49, p<0.001) and males (IRR=0.61, 95%CI 0.58-0.64), and less marked in patients with mental health conditions (IRR=0.75, 95%CI 0.72-0.79, p<0.001). Indicator reporting dropped for GP face-to-face consultations (IRR=0.88, 95%CI 0.80-0.97, p=0.011) and increased for remote consultations (IRR=1.22, 95%CI 1.11-1.34, p<0.001), but despite this, remained lower in remote consulting than face-to-face in April-July 2020.Conclusion Patient consulting in general, and for potential cancer indicators specifically, reduced during the first-wave of the COVID-19 pandemic. Remote consulting may be part of the reason for the reduction in reporting of potential cancer indicators, along with the reduced spreading of viral (non-cancer) infections.
Intraindividual coexistence of anthropometric undernutrition and “metabolic obesity” in Indian Children: A paradox that needs action
Authors: Sachdev Harshpal Singh , Porwal Akash , Sarna Avina , Acharya Rajib , Ramesh Sowmya , Kapil Umesh , Kurpad Anura V.
Published: December 2020

BackgroundIntraindividual coexistence of anthropometrically defined undernutrition and “metabolic obesity”, characterised by presence of at least one abnormal cardiometabolic risk factor, is rarely investigated in young children and adolescents, particularly in Low-and-Middle-Income-Countries undergoing rapid nutrition transition. MethodsPrevalence of biomarkers of metabolic obesity was related to anthropometric and socio-demographic characteristics in 5-19 years old participants from the population-based Comprehensive National Nutrition Survey in India (2016-2018). The biomarkers, serum lipid-profile (total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides), fasting glucose, and glycosylated hemoglobin (HbA1C), and all jointly were analysed in 22567, 23192, 25962 and 19143 participants, respectively.ResultsOverall (entire dataset), the prevalence of abnormalities was low (4.3-4.5%) for LDL and TC, intermediate for dysglycemia (10.9-16.1%), and high for HDL and triglycerides (21.7-25.8%). Proportions with ≥1 abnormal metabolic obesity biomarker(s) were 56.2% overall, 54.2% in thin (BMI-for-age <-2SD) and 59.3% in stunted (height-for-age <-2SD) participants. Comparable prevalence was evident in mild undernutrition (-1 to -2 SD). Clustering of two borderline abnormalities occurred in one-third, warranting active life-style interventions. Metabolic obesity prevalence increased with BMI-for-age. Among those with metabolic obesity, only 9% were overweight/obese (>1SD BMI-for-age). Among poor participants, triglyceride, glucose and HDL abnormalities were higher. ConclusionsA paradoxical, counter-intuitive prevalence of metabolic obesity biomarker(s) exists in over half of anthropometrically undernourished and normal-weight Indian children and adolescents. There is a crucial need for commensurate investments to address overnutrition along with undernutrition. Nutritional status should be characterized through additional reliable biomarkers, instead of anthropometry alone.
Large Number Hexagonal Cavities Microfluidic Digital Chip for Gene Mutation Ultrasensitive Analysis in Lung Cancer
Authors: Liu Fei , Feng Pan , Guo Mingjing , Li Gang , Xie Tengbao , Zhang Liqun , Pu Xiaoyun
Published: December 2020

Lung cancer is the highest incidence of malignant tumors in the world. Targeted therapy based on gene mutation detection including epidermal growth factor receptor (EGFR) gene mutation is one of the first-line treatments. In this work, took EGFR gene G719S mutation as a representative object, a large number hexagonal cavities microfluidic chip (LHMC) platform based on digital PCR (dPCR) for the absolute quantification of gene mutation in lung cancer was established. In this chip, 113,137 cavities chip was designed to increase the number of absolute quantitative, which was 2~5 times higher than the traditional one. The hexagonal shape of cavities elevates the filling rate and filling speed. A set of primers and probes for G719S with high sensitivity, high specificity and high reliability were designed and screened. Then the PCR parameters were optimized. The results demonstrated that the chip platform shows good performance. The minimum detection concentration of the gene mutant was 3.01 copies/μL, and a good correlation (Y= 0.725X- 0.581, R2= 0.984) was noted between the measured value and the expected value. This chip possesses sensitively detect positive mutations in G719S and completely negative when detecting other substances. The developed LHMC-dPCR chip is a rapid and accurate gene mutation analysis platform, which has faster speed and lower price than classic detection methods, for instance, droplet dPCR, DNA sequencing method. Moreover, LHMC-dPCR is not limited by the number of nucleic acids and droplets and there is no need to estimate the nucleic acid concentration of the sample. This chip platform could also detect other gene mutations, for example, L858R, exon 19 deletions, in other tumors including lung cancer.
Spatial-time Visualization of Cutaneous Leishmaniasis in an Urban Area: Informing Health Policy and Practice
Authors: Firouraghi Neda , Mostafavi Sayyed Mostafa , Raouf-Rahmati Amene , Mohammadi Alireza , Saemi Reza , Fakher Mahmoud , Hamer Davidson H , Moghaddas Elham , Kiani Behzad
Published: December 2020

Background:Cutaneous leishmaniasis (CL) is an important public health concern worldwide. Iran is among the most CL-affected countries, being listed as one of the first six endemic countries in the world. In order to develop targeted interventions, we performed a spatial-time visualization of CL cases in an urban area to identify high-risk and low-risk areas during 2016-2019.Methods:This cross-sectional study was conducted in the city of Mashhad. Patient data were gathered from Mashhad health centers. All cases (n=2425) were diagnosed in two stages; the initial diagnosis was based on clinical findings. Subsequently, clinical manifestation was confirmed by parasitological tests. The data were aggregated at the neighborhood and district levels and smoothed CL incidence rates per 100,000 individuals were calculated using the spatial empirical Bayesian approach. Furthermore, we used the Anselin Local Moran’s I statistic to identify clusters and outliers of CL distribution during 2016-2019 in Mashhad. Results:The overall incidence rates decreased from 34.6 per 100,000 in 2016 to 19.9 per 100,000 individuals in 2019. Both cluster analyses by crude incidence rate and smoothed incidence rate identified high-risk areas in southwestern Mashhad over the study period. Furthermore, the analyses revealed low-risk areas in northeastern Mashhad over the same 3-year period.Conclusions:The southwestern area of Mashhad had the highest CL incidence rates. This piece of information might be of value to design tailored interventions such as running effective resource allocation models, informed control plans and implementation of efficient surveillance systems. Furthermore, this study generates new hypotheses to test potential relationships between socio-economic and environmental risk factors and incidence of CL in areas with higher associated risks.
TPX2 Derived Vaccine to Inhibit Tumorigenesis and Metastasis in Triple Negative Breast Cancer 
Authors: Jiang Yueqiang , Liu Yan , Cheng Ling , Tan Xiaolong , Luo Jian , Yu Shiyin
Published: December 2020

Background: triple negative breast cancer (TNBC) lacks of treatment approaches rather than other subtypes of breast cancer. However, it characterizes the highest the level of tumor infiltrating lymphocyte (TIL) than other subtypes, indicating the possibility of immunotherapy. Method: female BALB/c background mice are immunized with a TPX2 derived vaccine 4 consecutive times (once a week) from 6 weeks old, and then 4T1 cells are transplanted to the #4 mammary fatpad. Surface tumor volume and No. of lung metastasis were recorded. TIL and splenocyte was collected for T cell subgroup analysis by methods of flow cytometry and IFN-γ ELISPOT. Result: as a result, TPX2 derived vaccine shows moderate effect, shrinking the tumor volume from 804.4 to 504.5 mm3, and decreasing the number of lung metastasis from 16.6 to 6.0 in control group compared to vaccine group. CD8+ T cell ratio are obviously increased in TIL between vaccine group and control group (5.87% vs 3.37%, P=0.0012). And vaccine could induce strong immune response both in tumor site (87.6 vs 7.0, p=0.0004) and system (28.2 vs 3.8, p＜0.0001) through IFN-γ ELISPOT. Conclusion: our result indicated that TPX2 derived vaccine may be an effective approach to inhibit TNBC tumorigenesis and metastasis.
Atmospheric pressure and population density as super-factors influencing the transmission of coronavirus disease 2019 (COVID-19)
Authors: Yan Wei , Nawaz Muhammad Zohaib , Xu Wenqian , Jiang Zheng , Sun Weixiang , Lai Jiayue , Shao Yinghui , Zhang Wei , Zhang Rui
Published: December 2020

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease (COVID-19), recently emerged and led to a global pandemic with enormous consequent losses to global health and economies. To date, more than 30 million cases have been reported globally and have affected almost every with varying degrees. Meteorological and non-meteorological factors such as temperature, relative humidity, atmospheric pressure, population density, and latitude, are considered critical in virus transmission. To explore the correlation of environmental factors with the transmission of SARS-CoV-2 based on parameters including infection rate, effective reproduction number, and compound growth rate, we analyzed data of confirmed cases from 487 counties in the United States. We found a small impact of temperature and humidity on virus transmission, but observed a considerable positive influence of atmospheric pressure and population density on virus transmission. Geographic areas and seasons (autumn and winter), with exposure to higher atmospheric pressure, are more likely at higher risk of an outbreak. Social distancing and other measures could be effective strategies to combat COVID-19 outbreaks in densely populated areas. Additional studies are needed to explore the mechanisms underlying the relationship between meteorological parameters and transmission of SARS-CoV-2.
The Utility of Routine Histopathological Examination of the Appendectomy Specimens
Authors: Hasan Abdulkarim , Nafie Khalid Mohamed , Abbadi Osama Sharafeldin , Ibrahim Adel Abdelwahid
Published: December 2020

Background: Appendectomy is the most commonly performed surgical procedure worldwide to manage appendicitis. The practice of sending all appendices specimens for routine histopathology examination depends on the concerned clinician. This study was performed to reveal the importance of routine histopathology examination of the appendectomy specimens with recording of the occurrence and distribution of unusual pathologic findings

Methods: This was a retrospective record based comparative study performed in a single Hospital in Saudi Arabia, where the medical files of 766 patients were recruited. The appendectomy specimens were obtained either from our hospital or referred from any other hospital for histopathology examination. All the unusual diagnoses were reviewed by the histopathology author and blindly re-evaluated by other pathology consultant. Statistic analysis was performed manually.

Result: 700 cases were within the usual histopathology scope. Unusual histopathological findings were observed in 66 cases (8.6%): four cases of mucinous neoplasms, 20 cases of fibrous obliteration or appendiceal neuroma, 18 cases showed parasitic infestation, and 24 cases were periappendicitis without appendicular acute inflammation.

Conclusion: Routine histopathology examination of the appendix not only confirms the clinical diagnosis of acute appendicitis, but also leads to the incidental diagnosis of much unusual pathologies which could have been missed by the surgeon, and these pathologies include parasitic infestation, peri-appendicitis, neuromas and appendiceal mucinous neoplasms.
Cytological Grading of Chronic Lymphocytic Thyroiditis and Correlation with Thyroid Profile
Authors: Sajjan Netra M , Vani B R , V Srinivasamurthy , Vijayakumari V
Published: December 2020

Background: Chronic lymphocytic thyroiditis is a thyroid specific autoimmune disease often seen in middle aged women, although rarely do occur in men, children1. This disease is characterized by antibody directed against thyroid peroxidase, called antimicrosomal antibody. The present study was undertaken to evaluate the various cytological features occurring in HT and to correlate with clinical and serological findings.

Methods: The study was conducted in department of Pathology from May 2017 to August 2017. The cases diagnosed as HT by FNAC were taken up for the study. Cytomorphologic features were reviewed microscopically and graded as per Bhatia et al.

Result: Fifty cases were diagnosed as lymphocytic thyroiditis. Age of the patient ranged from 7-56 years. Clinically 41 of 50 cases (82%) presented with diffuse thyroid enlargement. In our study we had 31 cases (62 %) of grade 2 thyroiditis, 15 and 4 cases each of grade 1 and grade 3 respectively. We observed increased TSH values in 100% of G3 thyroiditis and 64.5% of G2 thyroiditis. None of the Grade 1 thyroiditis had increased TSH levels. The statistical correlation between grades of thyroiditis with T3, T4 and TSH levels was found to be significant with p values < 0.05.

Conclusion: FNAC is simple cost effective and quick method for diagnosing HT. Also combined evaluation of HT with clinical findings and thyroid profile promotes more accurate diagnosis and early institution of therapy and follow up. FNAC is also necessary to rule out malignant lesions like lymphoma and papillary carcinoma at preliminary cytological level.
Challenges and considerations of applying nature-based solutions in low- and middle-income countries in Southeast and East Asia
Authors: Lechner Alex M. , Gomes Rachel L. , Rodrigues Lucelia , Ashfold Matthew J. , Selvam Sivathass Bannir , Wong Ee Phin , Raymond Christopher M. , Zieritz Alexandra , Sing Kong Wah , Moug Peter , Billa Lawal , Sagala Saut , Cheshmehzangi Ali , Lourdes Karen , Azhar Badrul , Sanusi Ruzana , Ives Christopher D. , Tang Yu-Ting , Tan David T. , Chan Faith Ka Shun , Nath Tapan Kumar , Sabarudin Nur Aliya Binti , Metcalfe Sarah E. , Gulsrud Natalie M. , Schuerch Mark , Campos-Arceiz Ahimsa , Macklin Mark G. , Gibbins Chris
Published: December 2020

Low- and middle-income countries in Southeast and East Asia face a range of challenges related to the rapid pace of urbanisation in the region, the scale of pollution, climate change, loss of ecosystem services and associated difficulties for ecological restoration. Possible pathways towards a more sustainable future lie in the applications of nature-based solutions (NBS). However, there is relatively little literature on the application of NBS in the region, particularly Southeast Asia. In this paper we address this gap by assessing the socio-ecological challenges to the application of NBS in the region – one of the most globally biodiverse. We first provide an overview and background on NBS and its underpinnings in biodiversity and ecosystem services. We then present a typology describing five unique challenges for the application of NBS in the region: (1) Characteristics of urbanisation; (2) Biophysical environmental and climatic context; (3) Environmental risks and challenges for restoration; (4) Human nature relationships and conflicts; and (5) Policy and governance context. Exploiting the opportunities through South-South and North-South collaboration to address the challenges of NBS in Southeast and East Asia needs to be a priority for government, planners and academics.
Natural organic matter and sulphate elimination from rainwater with nanofiltration technology and process optimisation using response surface methodology
Authors: Köse-Mutlu Börte
Published: December 2020

In the current study, the effect of operating conditions including membrane characteristics and applied pressure on natural organic matter and sulphate removal of nanofiltration (NF) membranes for drinking water production was investigated. Water stress has been increasing all over the world due to population growth, climate change, and pollution; rainwater management stands out as one of the key solutions to this problem. Nanofiltration to treat rainwater stored in a cistern was studied. The objectives were sufficient treatment performance to overcome the taste problem and lower energy consumption. In this regard, three commercial nanofiltration membranes (NP010, NP030, and NF90) were used for the experiments carried out at 6–12 bar operating pressure regarding the response surface methodology. The correlation among the results of experiments and the model parameters were also calculated for all steps. According to the results, the effect of membrane characteristics was more abundant than the effect of the operating pressure. Finally, over 99% of natural organic matter and sulphate were eliminated in the optimum conditions. The results showed that it is possible to obtain treated rainwater with desired qualities, in a non-continuous NF plant operated at the pressure of 6 bar to reuse the rainwater and achieve water sustainability.
O ILÊ OBÁ OGUNTÉ: PATRIMÔNIO E IDENTIDADE AFRO-BRASILEIRA
Authors: Campos Zuleica Dantas Pereira
Published: December 2020

O objetivo deste trabalho é refletir sobre o processo de patrimonialização ocorrido nas religiões afro-brasileiras e a importância atribuída à musealização da sua cultura, tanto material quanto imaterial. Para tanto, tomamos como estudo o Ilê Obá Ogunté, localizado no Recife, Pernambuco. O terreiro conta com o reconhecimento não só dos adeptos, mas de estudiosos especializados uma vez que se constitui no espaço de culto mais antigo em funcionamento na cidade. A partir de nossas investigações, buscamos explicitar que os processos de patrimonialização lidam com a religião e com a identidade afro-brasileira no sentido de inserir seus praticantes na história das lutas por legitimidade.
PATRIMÔNIO FESTIVO, ÉTNICO E TERAPÊUTICO: RELIGIÕES AFRO-BRASILEIRAS E CULTURA QUILOMBOLA
Authors: Tavares Fátima , Bassi Francesca , Caroso Carlos
Published: December 2020

Nos territórios quilombolas do município de Cachoeira, Bahia, observa-se um processo de florescimento cultural com algumas iniciativas de patrimonialização mobilizadas pelas comunidades. Nesse processo tem especial destaque a cultura afro-religiosa para uma parcela dessas comunidades, afinando-se a tendências mais amplas de inclusão gradual dos bens culturais das populações minoritárias, ampliando, assim, o escopo dos “bens culturais”. Neste artigo apresentamos algumas dessas iniciativas, a exemplo da Festa de São Roque e os peditórios da Esmola Cantada; de implantação do turismo étnico de base comunitária da Rota da Liberdade; de revalorização das terapêuticas tradicionais; e de mobilização político-cultural afro-religiosa da Festa da Ostra, locus de visibilização e inventividade de símbolos e experiências dessas comunidades. Nessas iniciativas, referentes materiais, sensoriais e estéticos afro-religiosos comparecem na fundamentação das “políticas de autenticidade” para a patrimonialização da cultura quilombola.
OS PRESENTES DE OXUM: SENTIDOS DA MUSEALIZAÇÃO NO TERREIRO DO GANTOIS
Authors: Adinolfi Maria Paula , Van de Port Mattijs
Published: December 2020

Este artigo discute como os aposentos de uma famosa sacerdotisa do candomblé foram transformados em um local patrimonializado. O Memorial de Mãe Menininha do Gantois mostra que o museu pode ser entendido como uma “linguagem” específica de status e prestígio. Esse lugar, portanto, permite refletir sobre o que acontece quando novos atores na esfera pública se apropriam e transformam essa linguagem. Embora as dimensões profanas da musealização sejam evidentes, argumentamos que, no caso deste memorial, esse processo não diminui a natureza sagrada desse sítio, mas a articula de uma nova maneira.
SABERES ESCRITOS, GUARDADOS: O ACERVO DOCUMENTAL DO CENTRO HUMILDE DE CARIDADE SÃO LÁZARO, NATAL – RN
Authors: Assunção Luiz
Published: December 2020

A proposta do artigo é refletir sobre os resultados do trabalho de pesquisa no qual se procura inventariar e proceder ao estudo do acervo cultural de bens do patrimônio material e imaterial religioso de comunidades tradicionais de terreiro de Natal (RN). Na primeira fase da pesquisa, foco da análise apresentada neste artigo, procedeu-se ao estudo do acervo do Centro Humilde de Caridade São Lázaro, localizado no bairro das Quintas (Natal, RN), fundado no início dos anos de 1960, pelo babalorixá José Barroso dos Santos, mais conhecido por Tenente Barroso. Iniciado no candomblé de nação ketu baiano, no entanto, serão a umbanda e sua prática curativa que o projetam no universo religioso afro-brasileiro da cidade. O acervo é composto por diferentes documentos, entre os quais: fotografias, livros (atividades, acompanhamento das obrigações), caderno dos pontos cantados, ofícios, imagens religiosas e objetos ritualísticos. No conjunto patrimonial, inclui-se, ainda, uma edificação construída no ano de 1966, especificamente para as atividades religiosas, atualmente objeto de uma disputa judicial por membros da família.
A DESTERRITORIALIZAÇÃO CAUSADA PELA VIOLÊNCIA BIOÉTNICA E OS PESCADORES ARTESANAIS DA BAÍA DE GUANABARA
Authors: Ferreira Cesar Bernardo , Puggian Cleonice
Published: December 2020

Este artigo apresenta os resultados de uma pesquisa sobre violência envolvendo os pescadores artesanais da baía de Guanabara, Rio de Janeiro. Examina como essa violência interfere no cotidiano desses trabalhadores, pois o cenário em que acontecem as violências é particularizado pela ocupação do espaço por grandes empreendimentos industriais, como a indústria do petróleo. Quanto aos aspectos metodológicos da pesquisa, optou-se pela metodologia etnográfica de cunho qualitativo através de trabalhos de campo (período de 2017 a 2019). Os instrumentos de coleta de dados foram a observação participante e a entrevista etnográfica, que foram gravadas em áudio e transcritas posteriormente por meio da tematização dos registros de campo e da narrativa dos participantes. Foram entrevistados ao todo 20 pescadores artesanais que atuam na baía de Guanabara. Para garantir a integridade e anonimato dos pescadores artesanais entrevistados, dei-lhes pseudônimos, para que que seus nomes verdadeiros não fossem revelados. Os resultados da presente pesquisa apontam para diversos casos de pescadores artesanais vitimados por armas de fogo oriundos dos agentes de segurança das plataformas e demais edificações da indústria petroquímica, com ênfase a Petrobras. Há ainda, vários relatos de pescadores vítimas de insultos verbais, cárcere privado, ameaças de morte, tortura, mutilações, omissão do Estado e prejuízos financeiros.
Hospitalidade no Buraco da Catita: Música e Comensalidade como opção de lazer em Natal/RN, Brasil
Authors: De Andrade Oliveira Cristiane Kateline , Melo da Cunha Silvânia , Almeida Gomes Dantas Amanda , Cavalcante Maria Bernadete , Moreira Sueli Aparecida
Published: December 2020

O presente estudo tem como objetivo caracterizar a hospitalidade do Bar e Espaço Cultural Buraco da Catita enquanto local de lazer e entretenimento através da comensalidade e musicalidade oferecidos, tendo em vista o crescente interesse dos turistas de vivenciar boas experiências conhecendo a cultura local através da gastronomia, música e do ambiente em que se encontram. Foram obtidos depoimentos dos proprietários e dos usuários em relação ao Bar Buraco da Catita; perfil dos usuários do bar, atratividade comensal e hospitalidade. As informações foram obtidas através de depoimentos e enquete, com auxílio de formulário semiestruturado contendo 09 perguntas, aplicado com 32 usuários do Buraco da Catita. Os resultados obtidos evidenciaram que o local pesquisado possui grande potencial turístico, pois alia 03 importantes aspectos, a gastronomia, a música e a edificação histórica. A gastronomia é o principal atrativo do lugar, em seguida encontra-se a música. O complexo música e comensalidade retratam a boa hospitalidade. Melhorias na qualidade em promover o lugar, sem que este perca sua essência, podem fomentar ainda mais o turismo e disseminar a cultura local.

Palavras-chave: Turismo Cultural. Comensalidade. Hospitalidade. Buraco da Catita. Ribeira.
Creative Economy, Cinema and Tourism: a study about the movie "Os Xeretas” in the city of Castro/ Paraná – Brazil
Authors: Gonçalves Alencar Débora , Lima dos Santos Marina , Guissoni Rodrigo
Published: December 2020

Os setores que correspondem às indústrias criativas, como o audiovisual, contribuem para as atividades turísticas. Este artigo apresenta uma relação direta entre esses setores por meio da imagem, da comunicação com o mercado, para estabelecer através da criatividade as relações entre o cinema (como a produção cinematográfica) e o cenário (como o destino turístico), além de fornecer novos recursos para a localidade, servir como exemplo ou modelo a ser seguido por outros destinos-cenário. Este artigo tem uma abordagem qualitativa e descritiva. Para entender o desempenho entre turismo e cinema, cujos elementos atribuem novos aspectos econômicos, sociais e culturais a um local após a produção do filme, esta pesquisa apresenta um estudo de caso do filme "Os Xeretas" (2001) gravado na cidade de Castro, estado de São Paulo. do Paraná - Brasil. Como resultado, houve a identificação de oportunidades para a cidade, como o incentivo ao desenvolvimento local, por meio do envolvimento entre pessoas, produtos e ambientes criativos entendidos como aspectos favoráveis à promoção do turismo.

Palavras-chave: Turismo. Cinema. Indústria Criativa. Desenvolvimento Local. Paraná - Brasil.
Silybin B and Cianidanol Inhibit Mpro and Spike Protein of SARS-CoV-2: Evidence from in silico Molecular Docking Studies
Authors: Srivastava Rashi , Tripathi Shubham , Unni Sreepoorna , Hussain Arif , Haque Shafiul , Dasgupta Nandita , Singh Vineeta , Mishra Bhartendu N.
Published: December 2020

Background:

The main proteases (Mpro) and Spike Proteins (SP) of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) play a major role in viral infection development by producing several
non-structural proteins (nsPs) and penetrating the host cells, respectively. In this study, the potential of in silico
molecular docking-based drug repositioning approach was exploited for identifying the inhibitors of Mpro and
SP of SARS-CoV-2.

Methods:

A total of 196 compounds, including various US-FDA-approved drugs, vitamins, and their analogs,
were docked with Mpro (PDB IDs: 6YB7 and 6Y84), and the top six ligands were further tested for ADME
properties, followed by docking with SP (PDB IDs: 6LXT and 6W41).

Results:

Out of 196 compounds, binding energy (DE) of Silybin B (6YB7: DE: -11.20 kcal/mol; 6Y84: DE: -
10.18 kcal/mol; 6LXT: DE: -10.47 kcal/mol; 6W41: DE: -10.96 kcal/mol) and Cianidanol (6YB7: DE: -8.85
kcal/mol; 6LXT: DE: -9.36 kcal/mol; 6Y84: DE: -10.02 kcal/mol; 6W41: DE: -9.52 kcal/mol) demonstrated
better binding and ADME properties compared with the currently endeavored drugs like Hydroxychloroquine
and Lopinavir. Additionally, Elliptinone, Diospyirin, SCHEMBL94263, and Fiboflavin have shown encouraging
results. Fiboflavin, an immunity booster, was found to inhibit both the Mpro and spike protein of SARSCoV-
2. It was observed that amino acid residues MET6, ALA7, PHE8, PRO9, ASP295, GLY302, VAL303,
and THR304 play significant roles in protein-ligand interactions through hydrogen bonds and Vander Waals
forces.

Conclusion:

Silybin B and Cianidanol showed excellent binding and ADME properties compared with the currently
endeavored drugs and can be exploited as therapeutic options against SARS-CoV-2 infection after experimental
validation and clinical trials.
The Therapeutic Potential of Purinergic Receptors in Alzheimer’s Disease and Promising Therapeutic Modulators
Authors: Pan Lili , Ma Yu , Li Yunchun , Wu Haoxing , Huang Rui , Cai Zhengxin , Wu Xiaoai
Published: December 2020

Recent studies have proven that the purinergic signaling pathway plays a key role in neurotransmission
and neuromodulation, and is involved in various neurodegenerative diseases and psychiatric
disorders. With the characterization of the subtypes of receptors in purinergic signaling, i.e. the
P1 (adenosine), P2X (ion channel) and P2Y (G protein-coupled), more attention has been paid to the
pathophysiology and therapeutic potential of purinergic signaling in the central nervous system disorders.
Alzheimer’s disease (AD) is a progressive and deadly neurodegenerative disease that is characterized
by memory loss, cognitive impairment and dementia. However, as drug development aimed to
prevent or control AD has series of failures in recent years, more researchers have focused on the
neuroprotection-related mechanisms such as purinergic signaling in AD patients to find a potential
cure. This article reviews the recent discoveries of purinergic signaling in AD, and summarizes the
potential agents as modulators for the receptors of purinergic signaling in AD-related research and
treatments. Thus, our paper provides an insight into purinergic signaling in the development of anti-
AD therapies.
MicroRNA: A Potential Diagnosis for Male Infertility
Authors: Forouhari Sedighe , Mahmoudi Elahe , Safdarian Esmat , Beygi Zahra , Gheibihayat Seyed Mohammad
Published: December 2020

Male infertility is one of the major global health problems, in particular, in more than half
of the affected men. Genetic factors are important for identifying men with idiopathic infertility along
with semen analysis. Valid and useful information can be obtained through non-invasive molecular
research. Among these, small single-stranded non-coding RNA molecules of microRNAs (abbreviated
miRNAs) are non-invasive biomarkers with a diagnostic value by regulating the post-transcriptional
gene silence through repression and prevention of the translation process. The association between
various types of male infertility and miRNA regulation changes has been evaluated to understand the
biological function of miRNA and gene targets. Accordingly, further study of the function of miRNAs
associated with reproductive disorders could lead researchers to further understand the molecular
mechanisms of male infertility in order to find effective biomarkers and therapeutic strategies. Therefore,
the present review article aimed at scrutinizing those researches investigating the altered miRNA
expression in testicles, epididymis, and spermatozoa.
Subastas en Plantas de Energía Solar Fotovoltaica y la Paridad de Red en el Perú
Authors: Arredondo James , Ramos Marco
Published: December 2020

En el presente trabajo se hace un análisis de la situación de paridad de red entre las fuentes de energía eléctrica convencionales para el caso del Perú, que vendría hacer la energía hidroeléctrica y termoeléctrica, con las recursos de energía renovables o simplemente energías renovables en este caso se analiza las energía solar fotovoltaica instalado entre Moquegua, Tacna y Arequipa. Se ve como se calculan las tarifas que pagan el usuario final de tipo residencial, así como las tarifas actuales proporcionadas por los organismos correspondientes. Posteriormente se ve la evolución de la energía solar fotovoltaica y las cuatro subastas que se dieron en el Perú, y como estos costos han ido descendiendo de manera significativa. Finalmente se ve que al final se logra el objetivo de conseguir la paridad de red.
Updating the Occurrence of the Soil Liquefaction Phenomenon in Peru
Authors: Alva Hurtado Jorge Elias Domingo , Ortiz Salas Carmen Eleana
Published: December 2020

We present the information available on the phenomenon of soil liquefaction in Peru due to the seismic action and its representation in a map of soil liquefaction areas. The map of soil liquefaction areas is drawn to the scale 1: 5'000,000 and presents distinctions between liquefaction and probable liquefaction cases, according to the interpretation of the information available in the literature. All the documentation that presents evidence of the phenomenon of liquefaction, such as the formation of small volcanoes of mud and sand, the violent expulsion of water from the soil, the presence of intense cracking and the differential settlements due to the seismic action, has been detailed in this article.
Estudio del Fenómeno de Excitación Sincrónica Lateral caso: Puente Peatonal "Rayitos de Sol"
Authors: León Deza Julio Alfredo , Melchor Placencia Carlos Javier , Sánchez Moya Victor
Published: December 2020

En las últimas décadas, numerosos puentes peatonales experimentaron vibraciones excesivas en la dirección lateral, casos como el Millenniun, Solferino y Toda entre los más conocidos, causando en los peatones dificultades para cruzarlos y muy frecuentemente requiriendo caras reparaciones. Esta investigación estudia el problema de las vibraciones laterales producidas por el cruce de peatones en puentes peatonales conocido como Fenómeno de excitación sincrónica lateral a través del análisis de vibración lateral de la pasarela adyacente al puente peatonal “Rayitos de Sol”, que cruza el rio Rímac, cerca al centro de Lima. Este puente en particular presentaba excesivas vibraciones laterales desde su construcción en 2006 hasta el momento que fue desarrollada este estudio en 2016. Esta situación particular constituyó un estado ideal para el desarrollo del trabajo experimental. Durante esta investigación fueron encontrados detalles particulares del fenómeno de excitación sincrónica lateral, el primero que la densidad peatonal es directamente proporcional a la probabilidad de ocurrencia del fenómeno, el segundo que el fenómeno es de naturaleza cíclica y la ocurrencia de una aceleración máxima a partir de la cual el peatón rompe su paso y el fenómeno decae.
Simulación numérica de flujo de aire en una brida de admisión de un vehículo de competición
Authors: Tolentino Masgo San Luis Baudilio , Campos Omar González , Ponce Clifford Orlando Torres , Figueroa Simón Antonio Caraballo , Hernández Juan Toledo
Published: December 2020

La brida de admisión es un dispositivo mecánico que restringe la cantidad de flujo másico de aire a ser inyectado al cilindro del motor, y es empleado en vehículos de competición. En el presente trabajo, el flujo de aire se simula en un dominio computacional 2D con simetría axial para la geometría de una brida de admisión convergente-divergente, con el fin de determinar las variaciones de los parámetros termodinámicos del campo de flujo. Para la simulación del flujo, se utilizó el código ANSYS-Fluent que aplica el método de volumen finito. Se emplearon las ecuaciones gobernantes para flujo compresible: ecuación de la masa, cantidad de movimiento, energía y estado; además, se empleó el modelo de turbulencia SST  de Menter. Los resultados del campo de flujo de densidad, velocidad, presión y temperatura, así como del número de Mach, para seis relaciones de presión, muestran variaciones de las magnitudes termodinámicas en diferentes regiones del dominio, antes y después de la onda de choque; así como las regiones donde se produce la separación y recirculación del flujo en las adyacencias de la pared divergente. Se concluye que, cuando se presenta el choque, la curvatura de la pared de la sección divergente contribuye con el desprendimiento de la capa límite, causando transición en el desarrollo del flujo. Además, para la presión de salida de , el flujo alcanza un valor máximo de Mach 1.8, y temperatura mínima de  180 K (-93 ºC); y en la salida de la brida el flujo alcanza un valor menor de Mach 1.
Pengembangan keterampilan pemodelan matematis bagi calon guru IPA
Authors: Widodo Wahono , Sari Dhita Ayu Permata , Suyanto Totok , Martini Martini , Inzanah Inzanah
Published: December 2020

Tingkat keterampilan pemodelan matematis di kalangan mahasiswa calon guru IPA, masih berada dalam kategori cukup dan rendah sehingga perlu ditingkatkan. Pada penelitian ini pengembangan keterampilan pemodelan matematis dilakukan dengan mengaplikasikan model pembelajaran ALLR (activity based, lesson learned, reflection) dalam kegiatan perkuliahan. Penelitian ini dilakukan dengan dua tahap, yaitu tahap persiapan (penyusunan buku model pembelajaran ALLR dan perangkat pembelajaran yang kemudian divalidasi dengan kategori valid) dan tahap penerapan pada Mata Kuliah Dasar-dasar IPA, khususnya materi pegas dan getaran dengan menggunakan desain one shot case study. Subjek penelitian ini adalah mahasiswa calon guru IPA PTN di Jawa Timur Indonesia yang berjumlah 28 mahasiswa. Teknik pengumpulan data dengan menggunakan tes dan rubrik. Data yang diperoleh kemudian dianalisis secara deskriptif kuantitatif dengan representasi yang berupa tabel yang memuat nilai rata-rata, SD, persentase ketuntasan terhadap KKM, dan deskripsi dalam bentuk histogram. Hasil penelitian menunjukkan bahwa Model pembelajaran ALLR dapat digunakan untuk mengembangkan keterampilan matematis bagi calon guru IPA. Adapun saran yang disampaikan adalah keterampilan pemodelan matematis ini masih perlu terus dilatihkan pada berbagai MK yang relevan dengan model pembelajaran ALLR. Developing of mathematical modelling skills for science pre-service teachers AbstractMathematical modelling skills level of pre service teachers is still on average and low category, so it needs to be improved. This study aimed to develop pre service teachers’ mathematical modelling skills by applying the ALLR (activity based, lesson learn, and reflection) learning model. This study was conducted in two stages, namely preparation stage and application stage. The first stage was the stage to prepare the ALLR learning model book, lesson plan, and student worksheet which have a valid category. Second stage was applied the lesson plan and the students worksheet using ALLR learning model to enhance mathematical modelling skills in the Basic Science Course. The topic discussed in this course was spring and vibration. The design of this study was one shot case study design. The subjects were 28 pre-service teachers of East Java, Indonesia. Data were collected by giving a test and rubrics. Then, the data were analysed descriptively and quantitatively in the form of table consist of the students’ achievement. The results showed that the lesson plan and student worksheet applied using ALLR learning model improved pre-service teachers’ mathematical modelling skills. It is suggested that mathematical modelling skills need to be trained in many other courses by applying ALLR learning model.