bluuebunny/crossref_metadata_2025 huggingface dataset:
YAP1::KMT2A fusion-positive sarcoma: An emerging soft tissue tumor entity with morphological features resembling a sclerosing epithelioid fibrosarcoma
Authors: Agarwal Ayush , Rekhi Bharat , Goel Vineeta , Bajpai Jyoti , Rastogi Sameer
Published: July 2024

Sclerosing epithelioid fibrosarcoma (SEF) and low-grade fibromyxoid sarcoma (LGFMS) constitute a morphological continuum with certain overlapping histopathological features and MUC 4 immunopositivity. SEF is characterized by EWSR1 gene rearrangement, is relatively more aggressive and shows a limited response to chemotherapy. Lately, a subset of tumors with morphological features of SEF, but lacking MUC4 immunostaining and EWSR1 gene rearrangement have been observed. We report the first case of YAP1::KMT2A-positive sarcoma from the Indian subcontinent along with a review of similar tumors reported previously. A case of 31-year-old male presented with a 3 cm painful lump in the right suboccipital region. Histopathological examination of the excised specimen revealed a cellular tumor composed of atypical spindle and epithelioid cells, exhibiting moderate nuclear pleomorphism, arranged in cords, embedded in a dense collagenous/hyalinized stroma. By immunohistochemistry, the tumor cells were diffusely positive for cyclin D1 and negative for MUC4, desmin, myogenin, β-catenin, STAT6, myoD1, SMA, and S100P. By fluorescence in-situ hybridization, EWSR1 gene rearrangement was negative. Next-generation sequencing (NGS) revealed YAP1exon5::KMT2Aexon4 fusion. Given a positive resection margin, he underwent a revision surgery involving wide local excision of the lesion including the outer table of the occipital bone followed by image-guided radiation therapy. Over 2 years of his follow-up, the patient is alive with no evidence of recurrence. Thus, YAP1::KMT2A positive sarcomas have distinct molecular and overlapping histopathological features with SEF, with relatively less aggressive disease course. Documentation of additional similar tumors with long-term follow-up is required.
Low-grade fibromyxoid sarcoma of the maxilla: A diagnosis not to be missed
Authors: Agrawal Shruti , Mishra Sonali , Raviraj Kavya Udyavar , Jha Nishi , Kumar Arvind , Madhupriya
Published: July 2024

Low-grade fibromyxoid sarcoma (LGFMS) is a rare malignant spindle cell neoplasm that characteristically involves the trunk and extremities. The bland morphological appearance of the tumor makes it notoriously difficult for the pathologist to identify in routine microscopic sections especially when the tumor is located at unconventional sites. This ensues significant therapeutic implications as the tumor is known for long-standing distant metastasis. This case involves a 48-year-old lady who was diagnosed with this tumor at an extremely uncommon site as maxilla. The case report highlights the importance of meticulous histological examination and careful selection of immuno-histochemical markers in diagnosing this entity which might otherwise be missed clinico-radiologically.
Triple Anterior Horn Insertion of the Medial Meniscus Combined with Posterior Horn Hypertrophy: A Rare Case and Brief Literature Review
Authors: Assiri Waad Mohammed , El Fouhil Ahmed Fathalla Ibrahim , Alyahya Khaleel I. , Atteya Muhammad
Published: July 2024

Anomalies of the medial meniscus (MM) are uncommon. The most frequently occurring anomaly is found in the anterior horn. This report describes for the first time a case of abnormal multiple insertions of the anterior horn of the MM (AHMM) combined with posterior horn hypertrophy, which was found incidentally during routine dissection of a separate left lower limb from an adult cadaver. The AHMM was found to have a standard attachment to the anterior surface of the tibia in addition to two additional bands. One of these bands was the anteromedial meniscofemoral ligament, which ran parallel and independent of the anterior cruciate ligament and ended at the intercondylar notch of the femur. The other band extended as the transverse ligament that connected the AHMM to the lateral meniscus. The posterior horn of MM was found to be hypertrophied. The clinical implications of these anomalies are discussed below along with a relevant literature review.
Effectiveness of KTP lasers in tooth bleaching, by comparing tooth color change after bleaching with KTP, Nd:YAG, Er:YAG, and diode laser system: A systematic review
Authors: Awati Aishwarya Sanjay , Paul Aishika , Dhaded Neha , Joshi Sonal B. , Lagali-Jirge Vasanti
Published: July 2024

This systematic review evaluated the role of Potassium-titanyl-phosphate (KTP) lasers in dental bleaching by comparing tooth color change and rise in intrapulpal temperature after bleaching with KTP, Neodymium-doped yttrium aluminum garnet (Nd:YAG), Er:YAG, and diode laser system. Following were the inclusion criteria: in vitro studies in English available in full text. Articles published between 2000 and 2021 were selected. The search for was conducted on PubMed, Cochrane library/CENTRAL, Wiley online library, ProQuest, Science Direct, and Hand searching/specialized registers. Keywords were used: “Lasers” [Mesh] and “Tooth bleaching” [Mesh] using Boolean operators. A total of four articles fulfilled the inclusion criteria. The quality assessment of studies included was undertaken independently as part of data extraction process. KTP lasers demonstrated more effectiveness in attaining color change in stained teeth and showed the lowest rise in intrapulpal temperature. Based on the data obtained in the present review, the choice of bleaching treatment is directly related to the type of discoloration, activation of the bleaching agent, and esthetic requirement. Although all bleaching procedures were effective in color change, the KTP laser showed better results when compared to other laser activation. The bleaching treatment protocol is directly related to the type of discoloration, activation of the bleaching agent, and esthetic requirement. It has been demonstrated that a faster change in color can be obtained when bleaching is performed in combination with a light source, i.e., power bleaching aiming for a more in-depth change of color.
Phytochemicals in vital tooth bleaching: Spectrophotometric evaluation of efficacy with papaya, pineapple, or kiwi extracts and 30% hydrogen peroxide
Authors: Solanki Manali N. , Attur Kailash Madivalayya , Vachhani Kiran A. , Patel Nikunj A. , Shah Moksha A. , Doshi Dhruvi M.
Published: July 2024

Context:

Dental bleaching, a common cosmetic treatment, typically uses hydrogen peroxide (H2O2). Yet, the search for natural options has prompted an investigation into fruit extract efficacies such as papain, bromelain, and actinidin for tooth whitening.

Aim:

The aim of this study was to evaluate the efficacy of 30% hydrogen peroxide and fruit extracts (papaya, pineapple, and kiwi) on human enamel using a spectrophotometer at different time intervals.

Study Design:

Eighty maxillary anterior teeth were stained with tea solution and evaluated for baseline color. They were then divided into four groups: hydrogen peroxide alone and hydrogen peroxide combined with papaya, pineapple, or kiwi extracts. Each group was further divided based on bleaching duration: 10 or 20 min.

Materials and Methods:

The color value of the bleached teeth was measured using a reflectance spectrophotometer. In order to analyze the data, one-way ANOVA, post hoc Tukey, and paired t-tests were used. The significance level was established at α =0.05.

Results:

Combining hydrogen peroxide with pineapple extract showed the highest efficacy, followed by papaya and kiwi extracts. Hydrogen peroxide alone also demonstrated significant bleaching efficacy, albeit lower than the combinations with fruit extracts.

Conclusion:

Combining hydrogen peroxide with pineapple and papaya extracts notably improves dental bleaching efficacy, as shown by reduced color difference (ΔE) values. This underscores the potential of natural enzymes in tooth whitening.
Multimodal Biometric Analysis: Exploring Lip Print, Fingerprint, and Blood Group Correlations in the Firozabad Populations
Authors: Singh Shailja , Minj Kimee Hiuna , Jamal Sana , Saharan Sameer , Mishra Priyakanksha , Singh Pushplata , Sinha Vaishali
Published: July 2024

Aim:

This study aimed to establish a relationship between blood groups, fingerprint types, and lip prints that can be utilized to distinguish between genders when identifying a person.

Materials and Methods:

The study was conducted among 200 female and male participants ages 28 of Firozabad-based populations. Along with the blood types, finger, and lip print patterns were also gathered. For statistical analysis, SPSS Normal H. Nie, standford, california, united states was employed. The qualitative factors’ frequency and percentages were determined.

Results:

In the present study, overall Type II lip print in males and Type III lip print in females, loop fingerprint pattern and blood group O(+)ve in both sexes were most prevalent, and our findings were matched with the study of Harsha and Jayaraj, in which Type II (39.9%), loops 27 (42.2%), and blood group O(+)ve were observed predominantly.

Conclusion:

Personal identification of an individual can be greatly aided by personal characteristics such as blood group type, fingerprints, and lip prints. The most frequent patterns in our study were the Type II lip pattern in the males and Type III lip pattern in females, blood group O+, and the loop fingerprint pattern.
Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future
Authors: Yin Zhiyuan , Kang Jiahui , Cheng Xuan , Gao Hui , Huo Shujia , Xu Haiwei
Published: July 2024

Müller glia, as prominent glial cells within the retina, plays a significant role in maintaining retinal homeostasis in both healthy and diseased states. In lower vertebrates like zebrafish, these cells assume responsibility for spontaneous retinal regeneration, wherein endogenous Müller glia undergo proliferation, transform into Müller glia-derived progenitor cells, and subsequently regenerate the entire retina with restored functionality. Conversely, Müller glia in the mouse and human retina exhibit limited neural reprogramming. Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders. Müller glia reprogramming in mice has been accomplished with remarkable success, through various technologies. Advancements in molecular, genetic, epigenetic, morphological, and physiological evaluations have made it easier to document and investigate the Müller glia programming process in mice. Nevertheless, there remain issues that hinder improving reprogramming efficiency and maturity. Thus, understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency, and for developing novel Müller glia reprogramming strategies. This review describes recent progress in relatively successful Müller glia reprogramming strategies. It also provides a basis for developing new Müller glia reprogramming strategies in mice, including epigenetic remodeling, metabolic modulation, immune regulation, chemical small-molecules regulation, extracellular matrix remodeling, and cell-cell fusion, to achieve Müller glia reprogramming in mice.
Using a machine learning algorithm and clinical data to predict the risk factors of disease recurrence after adjuvant treatment of advanced-stage oral cavity cancer
Authors: Huang Sheng-Yao , Hsu Ren-Jun , Liu Dai-Wei , Hsu Wen-Lin
Published: July 2024

ABSTRACT

Objectives:

Head-and-neck cancer is a major cancer in Taiwan. Most patients are in the advanced stage at initial diagnosis. In addition to primary surgery, adjuvant therapy, including chemotherapy and radiotherapy, is also necessary to treat these patients. We used a machine learning tool to determine the factors that may be associated with and predict treatment outcome.

Materials and Methods:

We retrospectively reviewed 187 patients diagnosed with advanced-stage head-and-neck cancer who received surgery and adjuvant radiotherapy with or without chemotherapy. We used eXtreme Gradient Boosting (XGBoost) – a gradient tree-based model – to analyze data. The features were extracted from the entries we recorded from the electronic health-care system and paper medical record. The patient data were categorized into training and testing datasets, with labeling according to their recurrence status within the 5-year follow-up. The primary endpoint was to predict whether the patients had recurrent disease. The risk factors were identified by analyzing the feature importance in the model. For comparison, we also used regression to perform the variate analysis to identify the risk factors.

Results:

The accuracy, sensitivity, and positive predictive value of the model were 57.89%, 57.14%, and 44.44%, respectively. Pathological lymph node status was the most important feature, followed by whether the patient was receiving chemotherapy. Fraction size, early termination, and interruption were the important factors related to radiotherapy and might affect treatment outcome. The area under the curve of the receiver operating characteristic curve was 0.58. The risk factors identified by XGBoost were consistent with those found by regression.

Conclusion:

We found that several factors were associated with treatment outcome in advanced-stage head-and-neck cancer. In future, we hope to collect the data according to the features introduced in this study and to construct a stronger model to explain and predict outcomes.
Exploration of the mechanism of tetramethoxyflavone in treating osteoarthritis based on network pharmacology and molecular docking
Authors: Chen Ping , Ye Baibai , Lin Cheng , Zhang Chenning , Chen Jia , Li Linfu
Published: July 2024

ABSTRACT

Objectives:

This study aimed to explore the potential mechanisms of TMF (5,7,3’,4’-tetramethoxyflavone) in treating osteoarthritis (OA) using network pharmacology and molecular docking.

Materials and Methods:

Databases including SwissTargetPrediction, BATMAN-TCM, PharmMapper, TargetNet, SuperPred, and SEA were utilized to screen the targets of TMF. “OA” was used as the disease keyword to predict OA-related genes through GeneCards, Therapeutic Target Database, PharmGKB, Online Mendelian Inheritance in Man, and Comparative Toxicogenomics Database. The Venn diagram was employed to identify the intersection of predicted targets between TMF and OA as potential targets for TMF in treating OA. The intersection targets were input into the STRING 12.0 online database to construct a protein–protein interaction (PPI) network and identify core targets. Subsequently, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the Metascape V3.5 online database platform. Finally, molecular docking between TMF and core targets was conducted using AutoDockTools 1.5.6.

Results:

A total of 228 intersection targets for TMF treating OA were obtained, and PPI network analysis identified 5 core targets: STAT3, SRC, CTNNB1, EGFR, and AKT1. GO enrichment analysis yielded 2736 results, while KEGG analysis identified 203 pathways. Most elated GO and KEGG items of TMF in treating OA may include hormonal responses, antiviral and anticancer effects, anti-inflammation, phosphorus metabolism, phosphate metabolism, nitrogen compound responses, cancer-related pathways, PI3K-Akt signaling pathway, and MAPK signaling pathway. Molecular docking revealed good binding affinities between TMF and all core targets except STAT3.

Conclusion:

TMF might act on multiple targets and activate diverse pathways to intervene in OA, revealing the molecular processes involved in TMF treatment of OA.
Use of Delphi methodology to select sustainability indicators on dairy farms: an exploration of environmental, economic, social and animal welfare dimensions
Authors: Sánchez-Hidalgo Melissa , Tadich Tamara
Published: July 2024

Sustainable livestock production is essential to ensure the availability of food and resources, and to address the social, economic, and environmental challenges that threaten conventional livestock production. While there is consensus among economic, social, and scientific groups on the need to assess sustainability to make decisions that protect resources for present and future generations, there are few sustainability assessment tools that address it holistically. The aim of this study was to develop an assessment tool applicable to farms by identifying the indicators currently applied in dairy farms, based on a systematic literature review and expert opinion. This study used the Delphi methodology to explore sustainability indicators at the farm level. A panel of seven expert researchers and academics in livestock sustainability and animal welfare participated in the study. A high level of consensus was found for 15 economic indicators, 14 social indicators, 20 environmental indicators, and 16 animal welfare indicators. Some indicators, such as financial autonomy, transmissibility, cow and labor productivity, husbandry system, labor intensity, community bonding, labor satisfaction, biodiversity, crop rotation, fertilization, manure management, and water management, showed a high level of consensus and were considered useful in assessing sustainability on dairy farms. In addition, livestock sustainability experts reached a high consensus on 16 animal welfare indicators that could be useful in assessing farm sustainability. These results provide a solid basis for sustainability indicators in the economic, social, environmental, and animal welfare dimensions, which could serve as a basis for developing a sustainability assessment tool for dairy farms.
Remission of type 2 diabetes mellitus
Authors: Nakhleh Afif , Halfin Elya , Shehadeh Naim
Published: July 2024

The surge in type 2 diabetes mellitus (T2DM) is tightly linked to obesity, leading to ectopic fat accumulation in internal organs. Weight management has become a cornerstone of T2DM treatment, with evidence suggesting that significant weight loss can induce remission. Remission, defined as sustained hemoglobin (HbA1c) below 6.5% for at least 3 months without medication, can be achieved through various approaches, including lifestyle, medical, and surgical interventions. Metabolic bariatric surgery offers significant remission rates, particularly for patients with severe obesity. Intensive lifestyle modifications, including low-calorie diets and exercise, have also demonstrated significant potential. Medications like incretin-based agents show robust results in improving beta-cell function, achieving glycemic control, and promoting weight loss. While complete remission without medication may not be attainable for everyone, especially those with severe insulin resistance or deficiency, early and aggressive glycemic control remains a crucial strategy. Maintaining HbA1c below 6.5% from the time of diagnosis reduces the risk of long-term complications and mortality. Moreover, considering a broader definition of remission, encompassing individuals with sustained control on medication, could offer a more comprehensive and inclusive approach to managing this chronic disease.
MicroRNA-630: A promising avenue for alleviating inflammation in diabetic kidney disease
Authors: Donate-Correa Javier , González-Luis Ainhoa , Díaz-Vera Jésica , Hernandez-Fernaud Juan Ramón
Published: July 2024

Diabetic kidney disease (DKD) is one of the complications of diabetes, affecting millions of people worldwide. The relentless progression of this condition can lead to kidney failure, requiring life-altering interventions such as dialysis or transplants. Accumulating evidence suggests that immunologic and inflammatory elements play an important role in initiating and perpetuating the damage inflicted on renal tissues, exacerbating the decline in organ function. Toll-like receptors (TLRs) are a family of receptors that play a role in the activation of the innate immune system by the recognition of pathogen-associated molecular patterns. Recent data from in vitro and in vivo studies have highlighted the critical role of TLRs, mainly TLR2 and TLR4, in the pathogenesis of DKD. In the diabetic milieu, these TLRs recognize diabetic-associated molecular signals, triggering a proinflammatory cascade that initiates and perpetuates inflammation and fibrogenesis in the diabetic kidney. Emerging non-traditional strategies targeting TLR signaling with potential therapeutic implications in DKD have been pro-posed. One of these approaches is the use of microRNAs, small non-coding RNAs that can regulate gene expression. This editorial comments on the results of this approach carried out in a rat model of diabetes by Wu et al, published in this issue of the World Journal of Diabetes . The results of the experimental study by Wu et al shows that microRNA-630 decreased levels compared to non-diabetic rats. Additionally, microRNA-630 exerted anti-inflammatory effects in the kidneys of diabetic rats through the modulation of TLR4. These findings indicate that the microRNA-630/TLR4 axis might represent a pathological mechanism of DKD and a potential therapeutic target capable of curbing the destructive inflammation characteristic of DKD.
Patient-centered care in diabetes care-concepts, relationships and practice
Authors: Chen Tsung-Tai , Su Wei-Chih , Liu Mei-I
Published: July 2024

We still do not have comprehensive knowledge of which framework of patient-centered care (PCC) is appropriate for diabetes care, which elements of PCC are evidence-based, and the mechanism by which PCC elements are associated with outcomes through mediators. In this review, we elaborate on these issues. We found that for diabetes care, PCC elements such as autonomy support (patient individuality), cooperation and collaboration (system-level approach), com-munication and education (behavior change techniques), emotional support (biopsychosocial approach), and family/other involvement and support are critically important. All of these factors are directly associated with different patient outcomes and indirectly associated with outcomes through patient activation. We present the practical implications of these PCC elements.
Insulin resistance as the molecular link between diabetes and Alzheimer's disease
Authors: Abdalla Mona Mohamed Ibrahim
Published: July 2024

Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that have seen a rising prevalence worldwide. Recent studies have indicated a possible link between DM and an increased risk of developing AD. Insulin, while primarily known for its role in regulating blood sugar, also plays a vital role in protecting brain functions. Insulin resistance (IR), especially prevalent in type 2 diabetes, is believed to play a significant role in AD's development. When insulin signalling becomes dysfunctional, it can negatively affect various brain functions, making individuals more susceptible to AD's defining features, such as the buildup of beta-amyloid plaques and tau protein tangles. Emerging research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to AD. This review aims to explore the rela-tionship between DM and AD, with a focus on the role of IR. It also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target IR. Understanding IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.
Clinical efficacy of endovascular revascularization combined with vacuum-assisted closure for the treatment of diabetic foot
Authors: Lei Feng-Rui , Shen Xiao-Fei , Zhang Chuang , Li Xin-Qing , Zhuang Hao , Sang Hong-Fei
Published: July 2024

BACKGROUND

The diabetic foot is a common cause of disability and death, and comorbid foot infections usually lead to prolonged hospitalization, high healthcare costs, and a significant increase in amputation rates. And most diabetic foot trauma is complicated by lower extremity arteriopathy, which becomes an independent risk factor for major amputation in diabetic foot patients.

AIM

To establish the efficacy and safety of endovascular revascularization (ER) combined with vacuum-assisted closure (VAC) for the treatment of diabetic foot.

METHODS

Clinical data were collected from 40 patients with diabetic foot admitted to the Second Affiliated Hospital of Soochow University from April 2018 to April 2022. Diabetic foot lesions were graded according to Wagner’s classification, and blood flow to the lower extremity was evaluated using the ankle-brachial index test and computerized tomography angiography of the lower extremity arteries. Continuous subcutaneous insulin infusion pumps were used to achieve glycemic control. Lower limb revascularization was facilitated by percutaneous tran-sluminal balloon angioplasty (BA) or stenting. Wounds were cleaned by nibbling debridement. Wound granulation tissue growth was induced by VAC, and wound repair was performed by skin grafting or skin flap transplantation.

RESULTS

Of the 35 cases treated with lower limb revascularization, 34 were successful with a revascularization success rate of 97%. Of these, 6 cases underwent stenting after BA of the superficial femoral artery, and 1 received popliteal artery stent implantation. In the 25 cases treated with infrapopliteal artery revascularization, 39 arteries were reconstructed, 7 of which were treated by drug-coated BA and the remaining 32 with plain old BA. VAC was performed in 32 wounds. Twenty-four cases of skin grafting and 2 cases of skin flap transplantation were performed. Two patients underwent major amputations, whereas 17 had minor amputations, accounting for a success limb salvage rate of 95%.

CONCLUSION

ER in combination with VAC is a safe and effective treatment for diabetic foot that can significantly improve limb salvage rates. The use of VAC after ER simplifies and facilitates wound repair.
Global trends in publications regarding macrophages-related diabetic foot ulcers in the last two decades
Authors: Wen Jian-Ping , Ou Shuan-Ji , Liu Jia-Bao , Zhang Wei , Qu Yu-Dun , Li Jia-Xuan , Xia Chang-Liang , Yang Yang , Qi Yong , Xu Chang-Peng
Published: July 2024

BACKGROUND

Diabetic foot ulcers (DFUs) are one of the most severe and popular complications of diabetes. The persistent non-healing of DFUs is the leading cause of ampu-tation, which causes significant mental and financial stress to patients and their families. Macrophages are critical cells in wound healing and perform essential roles in all phases of wound healing. However, no studies have been carried out to systematically illustrate this area from a scientometric point of view. Although there have been some bibliometric studies on diabetes, reports focusing on the investigation of macrophages in DFUs are lacking.

AIM

To perform a bibliometric analysis to systematically assess the current state of research on macrophage-related DFUs.

METHODS

The publications of macrophage-related DFUs from January 1, 2004, to December 31, 2023, were retrieved from the Web of Science Core Collection on January 9, 2024. Four different analytical tools: VOSviewer (v1.6.19), CiteSpace (v6.2.R4), HistCite (v12.03.07), and Excel 2021 were used for the scientometric research.

RESULTS

A total of 330 articles on macrophage-related DFUs were retrieved. The most published countries, institutions, journals, and authors in this field were China, Shanghai Jiao Tong University of China, Wound Repair and Regeneration, and Aristidis Veves. Through the analysis of keyword co-occurrence networks, historical direct citation networks, thematic maps, and trend topics maps, we synthesized the prevailing research hotspots and emerging trends in this field.

CONCLUSION

Our bibliometric analysis provides a comprehensive overview of macrophage-related DFUs research and insights into promising upcoming research.
Serum tumor markers: Can they clinically implicate in type 2 diabetes mellitus?
Authors: Reddy Kotha Sugunakar , Pandiaraj Ilakkiya Priya , Gaur Archana , Varatharajan Sakthivadivel
Published: July 2024

“Serum tumor markers expression (CA19-9, CA242, and CEA) and its clinical implications in type 2 diabetes mellitus” authored by Meng and Shi presents an observational case-control study investigating the correlation between tumor markers and type 2 diabetes mellitus (T2DM). The study explores the diagnostic accuracy of tumor markers, particularly cancer antigen 19-9 (CA19-9), CA242, and carcinoembryonic antigen, in poorly controlled T2DM patients with hemoglobin A1c levels exceeding 9%, employing receiver operating characteristic curve analysis. Though study offers valuable insights into the potential utility of tumor markers in clinical practice, caution is advised regarding routine tumor marker testing due to challenges such as limited availability and cost. Additionally, the study overlooks potential confounding factors like smoking and alcohol consumption. Variations in CA19-9 and CA242 expression underscore the complex interplay between tumor markers and systemic diseases, warranting further investigation into their diagnostic and prognostic implications. While Meng and Shi represent a significant contribution to the field, more extensive research is needed to fully elucidate the role of tumor markers in diabetes management and beyond.
Bidirectional link between periodontitis and systemic inflammation in diabetic retinopathy
Authors: Nishant Prateek , Sinha Sony , Sinha Ranjeet Kumar , Morya Arvind Kumar
Published: July 2024

Periodontitis is independently associated with numerous lifestyle diseases. Diabetic patients have approximately threefold increased odds of periodontitis, which in turn increases the risk of systemic inflammation. The study by Thazhe Poyil et al is an effort to establish the inflammatory link between diabetic re-tinopathy (DR) and periodontitis based on the periodontal inflamed surface area in diabetic patients with and without DR. To further advance the study, we suggest refining the eligibility criteria to explicitly state the clinical correlates of periodontitis and DR, larger sample size and improved sampling methodology, matching of baseline characteristics of the two groups, as well as improved statistical approach and interpretation of the study findings. Measurement of hemoglobin A1c (HbA1c) in studies comparing type 2 diabetes mellitus patients with DR of matched severity with and without periodontitis could provide a clearer picture of whether HbA1c level is indeed influenced by periodontitis.
Advancements in endoscopic hemostasis for non-variceal upper gastrointestinal bleeding
Authors: Li Xue Jing , Fung Brian M
Published: July 2024

Non-variceal upper gastrointestinal (GI) bleeding is a significant cause of morbidity and mortality. Traditionally, through-the-scope (TTS) clips, thermal therapy, and injection therapies are used to treat GI bleeding. In this review, we provide an overview of novel endoscopic treatments that can be used to achieve hemostasis. Specifically, we discuss the efficacy and applicability of over-the-scope clips, hemostatic agents, TTS doppler ultrasound, and endoscopic ultrasound, each of which offer an effective method of reducing rates of GI rebleeding.
Remimazolam for sedation in gastrointestinal endoscopy: A comprehensive review
Authors: Dahiya Dushyant Singh , Kumar Ganesh , Parsa Syeda , Gangwani Manesh Kumar , Ali Hassam , Sohail Amir Humza , Alsakarneh Saqr , Hayat Umar , Malik Sheza , Shah Yash R , Pinnam Bhanu Siva Mohan , Singh Sahib , Mohamed Islam , Rao Adishwar , Chandan Saurabh , Al-Haddad Mohammad
Published: July 2024

Worldwide, a majority of routine endoscopic procedures are performed under some form of sedation to maximize patient comfort. Propofol, benzodiazepines and opioids continue to be widely used. However, in recent years, Remimazolam is gaining immense popularity for procedural sedation in gastrointestinal (GI) endoscopy. It is an ultra-short-acting benzodiazepine sedative which was approved by the Food and Drug Administration in July 2020 for use in procedural sedation. Remimazolam has shown a favorable pharmacokinetic and pharmacodynamic profile in terms of its non-specific metabolism by tissue esterase, volume of distribution, total body clearance, and negligible drug-drug interactions. It also has satisfactory efficacy and has achieved high rates of successful sedation in GI endoscopy. Furthermore, studies have demonstrated that the efficacy of Remimazolam is non-inferior to Propofol, which is currently a gold standard for procedural sedation in most parts of the world. However, the use of Propofol is associated with hemodynamic instability and respiratory depression. In contrast, Remimazolam has lower incidence of these adverse effects intra-procedurally and hence, may provide a safer alternative to Propofol in procedural sedation. In this comprehensive narrative review, highlight the pharmacologic characteristics, efficacy, and safety of Remimazolam for procedural sedation. We also discuss the potential of Remimazolam as a suitable alternative and how it can shape the future of procedural sedation in gastroenterology.
Recognition and management of stent malposition in the portal vein during endoscopic retrograde cholangiopancreatography: A case report
Authors: Wu Rui , Zhang Feng , Zhu Hao , Liu Ming-Dong , Zhuge Yu-Zheng , Wang Lei , Zhang Bin
Published: July 2024

BACKGROUND

Portal vein injury is an uncommon complication of endoscopic retrograde cholangiopancreatography (ERCP), for which stent malpositioning in the portal vein is very rare and can lead to fatal events. We report a case of biliary stent migration to the portal vein and a novel method for its safe removal under the guidance of portal angiography. Moreover, we reviewed the literature and summarized reports on the identification and management of this condition.

CASE SUMMARY

A 59-year-old woman with pancreatic cancer presented with abdominal pain and a high fever 20 days after the placement of two plastic biliary stents under the guidance of ERCP. Blood cultures and laboratory tests revealed sepsis, which was treated with antibiotics. A contrast-enhanced computed tomography scan revealed that one of the biliary stents in the main portal vein was malpositioned. To safely remove the stent, portal angiography was performed to visualize the portal vein and to allow the management of any bleeding. The two stents were removed without obvious bleeding, and an uncovered self-expanding metal stent was placed in the common bile duct for drainage. The patient had an uneventful 6-month follow-up period, except for self-resolving portal vein thrombosis.

CONCLUSION

The combination of endoscopic and angiographic techniques allowed uneventful management of stent malposition in the portal vein.
Prevodi naslovov slovenske proze na Poljskem
Authors: Gawlak Monika
Published: July 2024

This article discusses the different approaches translators take to translating the titles of prose works. The matter seems important not only because the title must retain its main functions in the target language; a comprehensive analysis of the relationship between the original title and the work is also needed, as well as a consideration of the »representational« role of the title in a secondary cultural setting. Attention is devo­ted to the titles of selected novels and collections of short prose, titles that retain a characteristic element of foreignness, and those that deviate greatly from the titles of the originals.
Najnovejši prevodi slovenske književnosti v slovaščino
Authors: Kmecová Svetlana
Published: July 2024

This article focuses on the most recent book and magazine translations of Slovenian literature into Slovak that have been published since 2020. Texts translated as part of literary festivals are also taken into account. It can be noted that the issues and tendencies already apparent in the past are also evident in this period, in particular the limited number of active translators, their personal commitment, and the strong influence of economic factors. However, the presence of Slovenian literature in all the fields mentioned, the selection of quality works that have a positive impact on the reception of Slovenian literature in Slovakia, and the genre differentiation of the resulting translations are all encouraging.
Izidor ali Isidore? Agata ali Agatha? Osebna imena v prevodih
Authors: Pogačar Timothy
Published: July 2024

The article considers translators’ practice of leaving personal names in translations as they appear in the original. A name is the primary characteristic of a literary character that the reader encounters, and a literary character often represents an entire work in the reader’s memory, frequently appearing in the title (e.g., Anna Karenina or Oliver Twist). The article weighs the effects of using original names in translations, including their phonetic impression, with a focus on translations from Slovenian, and it concludes that translators into English have gradually come to preserve Slovenian spellings.
Problematika slovensko-slovaškega avdiovizualnega prevajanja (na primeru priprave sinhronizacije koprodukcijskega filma Kapa)
Authors: Vojtech Poklač Saša , Vojtech Miloslav
Published: July 2024

This article presents the preparation of Slovak dubbing for the Slovenian–Luxembourgish–Croatian–Slovak Christmas feature film Beanie by the director Slobodan Maksimović and screenwriter Saša Eržen from 2022. It focuses on the stages and special features of the translation of the Slovenian script into Slovak and also analyzes the translation of cultural details related to the Christmas season. Of interest are adaptations of film characters’ names for the needs of Slovak child viewers, translations of parody song lyrics, and so on. The article also discussed the adaptation of dialogue that needed to be translated to match the visual element of the film.
Podoba prekmurščine in odnos do knjižnosti v slovenskem prostoru danes
Authors: Tivadar Hotimir
Published: July 2024

The Slovenian linguistic environment is characterized by a great regional diversity of language in private use, a special role in which is played by dialects as a valuable part of Slovenian culture. Regional speech expressions and regional coloring are becoming increasingly visible in public use, in which the Prekmurje dialect, which served as an independent standardized language the longest, stands out as the most idio­syncratic dialect and the one with the most developed body of literature. Based on historical facts and a presentation of the former and current linguistic situation, alonga with concrete examples from Prekmurje, this article describes and analyzes the viability and independence of Slovenian dialects in Slovenian society in relation to standard Slovenian.
Podobe v kratki pripovedi Ivanke Hergold
Authors: Zupan Sosič Alojzija
Published: July 2024

Research on three images – an old woman, an old man, and a dog – in three collections of Ivanka Hergold’s short stories – Pasja radost ali karkoli (Dog’s Joy or Whatever), Vse imaš od mene (You’ve Got Everything from Me), and Pojoči oreh (The Singing Walnut) – has revealed many thematic and narrative innovations. Among the themes, the suggestive images of a grandmother, grandfather, mother, and dog near death are the most effec­tive, and at the narrative level it is fairytale or fantastic logic, scripting, and lyricism. Lyricization as a dominant digressive process in the six narratives discussed – »Pravljica o dečku in dedku« (The Tale of the Boy and the Grandfather), »Prazna hiša« (The Empty House), »Pes Alfonz« (Alphonse the Dog), »Ko pride ura« (When the Hour Comes), »Tretji sin« (The Third Son), and »Pojoči oreh« (The Singing Walnut)—is characterized by rhythmi­cization and condensation of descriptions into polysemous aesthetic images. Among the images of the old woman, the old man, and the dog, the story »Pojoči oreh« (The Singing Walnut) from the collection of the same name stands out for its innovative suggestiveness, in which the image of the grandfather merges into the (sound) image of the singing walnut. The empathy and sublimity of the images once again proves the quality of the author’s oeuvre, which calls out for appropriate canonization.
Sociolingvistični okvir in tolmači v italijanskih fašističnih koncentracijskih taboriščih za jugoslovanske civiliste (1941–1943)
Authors: Dorigo Marco
Published: July 2024

This article is based on a doctoral dissertation, and it discusses the linguistic situation in the Italian Fascist camps for Yugoslav civilians, especially the sociolinguistic framework and status of interpreters in them. These camps established by Fascist Italy operated from 1941 to 1943. The study presented is interdisciplinary in nature, combining a sociolinguistic perspective with translation studies, and taking into account the general historical context. The dissertation, which is briefly presented, is the first sociolinguistic study of Italian con­centration camps for Yugoslav civilians and of their interpreters. The work, currently only in Italian, promotes a greater awareness of the crimes committed by the Italian Fascist regime against Slovenian and Croatian civilians during Italy’s annexation of Slovenia and Croatia.
A study on the need for a commercial management corporation to revitalize the local economy from an urban regeneration perspective: Focusing on the case of the formation of a power plant in the traditional market in Seoul, Jung-gu
Authors: Jung Kyoung Won , Lee Jae Gyu , Jang Young Ho ,   Korea Institute of Design Research Society
Published: July 2024

Urban regeneration in Korea is bringing about changes in the implementation pattern over time, and has now shifted to improving private investment. Regarding the concept of ‘n-minute city’, by examining Paris’s 15-minute urban plan and Seoul’s 30-minute pedestrian living zone, it was confirmed that the living zone is concentrated around the alley economy. Through local commercial districts and the Regional Commercial District Act, it was found that the policy direction of Korea's commercial district support projects in the future will be organized into regional commercial districts through private-centered commercial district professional managers. Through case studies in the US, UK, and Japan, we were able to gain insight into the necessity and direction of a private-centered commercial management organization to solve regional problems and create a sustainable profit model. Lastly, by deriving current problems through analysis of the trends and policies of our country's commercial districts and the current status of traditional market commercial districts, we have a direction on the need for a private-centered commercial management company based on the concept of a local management company for existing traditional market commercial districts. was able to check.
Research on Interactive Media Design Methods in Intangible Cultural Heritage Exhibition Design
Authors: Di Guo Ning , Kim Sang Ho , Yoon Jae Eun ,   Korea Institute of Design Research Society
Published: July 2024

This study explores design methodologies for interactive media in intangible cultural heritage exhibitions and addresses various issues arising from the rapid development of digital media technologies. The research first analyzes the harmonious characteristics between intangible cultural heritage exhibition design and interactive media technologies, and evaluates the application status of interactive media in various types of intangible cultural heritage exhibitions. The study focuses on three main themes: exploring nonlinear layouts and participation, innovative interactions between digital media and physical mediums, and building comprehensive exhibition platforms. The findings reveal that first, there is a distinct harmony between intangible cultural heritage exhibition design and interactive media technologies; second, the rational use of interactive media technology significantly enhances visitor engagement and experience; and lastly, comprehensive exhibition platforms require continuous adjustment of structure, remediation of flaws, and sustenance of innovation in intangible cultural heritage exhibition design.
A study on user experience of media art exhibitions: Focusing on a survey targeting Koreans
Authors: Park Jung Ho , Nah Ken ,   Korea Institute of Design Research Society
Published: July 2024

This study was designed to determine how the general public understands and accepts media art, which has recently emerged. Accordingly, this study conducted a survey to determine the level of awareness of the general public regarding current media art. Although there are various technical methodologies for practically implementing media art, it was confirmed that only a small number of production methods are accepted by the general public. In addition, media art-related exhibitions to be promoted in Korea are likely to have many popular themes that can be viewed with companions such as family and acquaintances, and the government, companies, and local governments can attract large-scale response or interest in specific events. The possibility of it being implemented in a certain way is also high. In this process, it is also believed that there is a high possibility that directing techniques that are easy to implement in a large format will be selectively selected. In this situation, it is judged that policy supplementation is necessary to ensure continuous development and diversity in the media arts field.
Analyzing the Relevance between the Display of Ethnic Intangible Cultural Heritage and Ethnic Communities: A Case Study of the Suoga Longhorn Miao Community in Guizhou, China
Authors: Hu Ting , Min Kyeonghoon ,   Korea Institute of Design Research Society
Published: July 2024

This study explores the relationship between ethnic intangible cultural heritage exhibitions and the corresponding communities, based on the (UNESCO 2003) Convention for the Safeguarding of the Intangible Cultural Heritage. It emphasizes the dynamic nature of cultural heritage and the vital role of ethnic communities as participants. The study uses three dimensions - “cultural empowerment,” “cultural identity,” and “community participation” - to explore this relationship. It uses the Soga Changjiao Miao community in Guizhou, China as a case study, concluding that ethnic community groups play a significant role in constructing ethnic intangible cultural heritage exhibitions. It's offers a valuable perspective for researchers.
Healing Agriculture Development Plan from a Service Design Perspective
Authors: Lee Seung Hwan ,   Korea Institute of Design Research Society
Published: July 2024

Healing agriculture is attracting attention as a new industrial field that contributes to improving people's health and quality of life by utilizing the pluralistic functions of agriculture. This study suggests that the perspective and methodology of service design can be effectively applied in seeking the development direction of healing agriculture. Through a literature review and analysis of domestic and international best practices, it was confirmed that principles such as user-centeredness of service design, stakeholder participation, and use of ICT technology can contribute to the design and improvement of therapeutic agriculture programs. In addition, the development potential of healing agriculture as a 6th industry was highlighted in terms of revitalizing the local economy and creating social value. Based on the analysis results, policy and practical recommendations for revitalizing healing agriculture were derived. It was proposed that service design education be included as a mandatory part of the training process for healing agriculture professionals, that user experience indicators be reflected in the healing farm certification evaluation, and that a collaborative governance system between relevant ministries and the private sector be established. This study emphasizes that the introduction of service design is essential for the sustainable growth of healing agriculture, and suggests that in-depth research and policy support to support this are required.