bluuebunny/crossref_metadata_2025 huggingface dataset:
The estimation of long and short term survival time and associated factors of HIV patients using mixture cure rate models
Authors: Ghobadi Khadijeh Najafi , Roshanaei Ghodratollah , Poorolajal Jalal , Shakiba Ebrahim , KHassi Kaivan , Mahjub Hossein
Published: May 2023

Background

HIV is one of the deadliest epidemics and one of the most critical global public health issues. Some are susceptible to die among people living with HIV and some survive longer. The aim of the present study is to use mixture cure models to estimate factors affecting short- and long-term survival of HIV patients.

Methods

The total sample size was 2170 HIV-infected people referred to the disease counseling centers in Kermanshah Province, in the west of Iran, from 1998 to 2019. A Semiparametric PH mixture cure model and a mixture cure frailty model were fitted to the data. Also, a comparison between these two models was performed.

Results

Based on the results of the mixture cure frailty model, antiretroviral therapy, tuberculosis infection, history of imprisonment, and mode of HIV transmission influenced short-term survival time (p-value < 0.05). On the other hand, prison history, antiretroviral therapy, mode of HIV transmission, age, marital status, gender, and education were significantly associated with long-term survival (p-value < 0.05). The concordance criteria (K-index) value for the mixture cure frailty model was 0.65 whereas for the semiparametric PH mixture cure model was 0.62.

Conclusion

This study showed that the frailty mixture cure models is more suitable in the situation where the studied population consisted of two groups, susceptible and non-susceptible to the event of death. The people with a prison history, who received ART treatment, and contracted HIV through injection drug users survive longer. Health professionals should pay more attention to these findings in HIV prevention and treatment.
Value of transrectal ultrasound-guided biopsy in endoscopy negative biopsy patients with rectal lesions
Authors: Li Tingting , Lu Man , Li Yuan , Yang Wei
Published: May 2023

Objective

To evaluate the value of transrectal ultrasound (TRUS) guided biopsy in endoscopy negative biopsy patients with rectal lesions.

Methods

150 endoscopy negative biopsy result rectal lesions adopted the transrectal ultrasound-guided biopsy. Based on whether the patients received contrast-enhanced ultrasound examination or not before the biopsies, all enrolled cases were divided into TRUS guided group and contrast-enhanced TRUS (CE-TRUS) guided group, and the safety and diagnostic performances were analyzed retrospectively.

Results

We obtained adequate specimens in the majority of cases (98.7%,148/150); There were no complications identified in our study. 126 patients received contrast-enhanced TRUS examination before biopsy to evaluate vascular perfusion and necrosis. The sensitivity, specificity, PPV, NPV, and overall accuracy of all biopsies were 89.1%, 100%,100%, 70.4%, and 91.3% respectively; The sensitivity, specificity, PPV, NPV, and accuracy for TRUS-guided biopsy and CE-TRUS guided biopsy were 73.7%, 100%,100%, 50%,79.2% and 92.1%,100%,100%,75%,93.6% separately; The increase in correct diagnoses was significant (p < 0.05) between TRUS guided biopsy and CE-TRUS guided biopsy.

Conclusion

TRUS-guided biopsy is a reliable procedure that can be augmented by endoscopic biopsy techniques if the biopsy yields negative results. CE-TRUS might assist in the location of the biopsy and decrease sampling errors.
Walking aids and complicated orthopedic diseases are risk factors for falls in hemodialysis patients: an observational study
Authors: Ishii Takeo , Matsumoto Wataru , Hoshino Yui , Kagawa Yasuhiro , Iwasaki Emi , Takada Hiromi , Honma Takashi , Oyama Kunio
Published: May 2023

Background

Aging and an increased fall risk have been demonstrated in hemodialysis patients at home and in a facility. However, studies investigating the cause of falls to prevent fractures in dialysis rooms are scarce. This study aimed to explore the related factors for accidental falls statistically in dialysis facilities for future fall prevention.

Methods

This study included 629 hemodialysis patients with end-stage renal disease. The patients were divided into two groups: the fall and non-fall groups. The main outcome was the presence or absence of falls in the dialysis room. Univariate and multivariate logistic analyses were performed; multivariate analysis was conducted using covariates significantly correlated in the univariate analysis.

Results

A total of 133 patients experienced falling accidents during the study period. The multivariate analysis indicated that the use of walking aid (p < 0.001), orthopedic diseases (p < 0.05), cerebrovascular disease, and age were significantly correlated with falls.

Conclusions

In the dialysis clinic, patients who use walking aids and have complicated orthopedic or cerebrovascular conditions are at a high risk of falling in the dialysis room. Therefore, establishing a safe environment may help prevent falls, not only for these patients but also among other patients with similar conditions.
Implementation fidelity of infection prevention practices at Debre Tabor comprehensive specialized hospital, Northwest Ethiopia
Authors: Gebeyehu Endalkachew Mesfin , Debie Ayal , Yazachew Lake , Fetene Samrawit Mihret , Azanaw Kefyalew Amogne
Published: May 2023

Background

Healthcare-Acquired Infections are a major problem in the world and within the healthcare delivery system. An estimated 5–10% and around 25% of hospitalized patients have healthcare-acquired infections in developed and developing countries, respectively. Infection prevention and control programs have proven to be successful in lowering the incidence and spread of infections. Thus, this evaluation aims to evaluate the implementation fidelity of infection prevention practices at Debre Tabor comprehensive specialized hospital in Northwest Ethiopia.

Methods

A facility-based cross-sectional design with a concurrent mixed method was used to evaluate the implementation fidelity of infection prevention practices. A total of 36 indicators were used to measure adherence, participant responsiveness, and facilitation strategy dimensions. A total of 423 clients were administered for an interview, an inventory checklist, a document review, 35 non-participatory observations, and 11 key informant interviews were conducted. A multivariable logistic regression analysis was used to identify factors significantly associated with the satisfaction of clients. The findings were presented using descriptions, tables, and graphs.

Result

The overall implementation fidelity of the infection prevention practices was 61.8%. The dimensions of adherence to infection prevention and control guidelines were 71.4%, participant responsiveness was 60.6%, and facilitation strategy was 48%. In multivariable analysis, ward admission and educational level had a p-value of below 0.05 and were significantly associated with the satisfaction of clients with infection prevention practices at the hospital. The major themes that emerged in qualitative data analysis were healthcare worker-related factors, management-related factors, and patient- and visitor-related factors.

Conclusion

The evaluation result of this study concluded that the overall implementation fidelity of infection prevention practice was judged to be medium and needed improvement. It included dimensions of adherence and participant responsiveness that were rated as medium, as well as a facilitation strategy that was rated as low. Enablers and barriers were thematized into factors related to healthcare providers, management, institutions, and patient and visitor relations.
Diabetic nephropathy with marked extra-capillary cell proliferation: a case report
Authors: Morimoto Madoka , Namba-Hamano Tomoko , Notsu Shoki , Iwata Yukimasa , Yasuhara Yumiko , Yamato Masafumi , Isaka Yoshitaka
Published: May 2023

Background

Extra-capillary hypercellularity is a common finding in crescentic glomerulonephritis (GN) and focal segmental glomerulosclerosis (FSGS). In diabetic nephropathy (DN), extra-capillary hypercellularity is often observed as a finding of complications such as IgA nephropathy or microscopic polyangiitis superimposed on DN. However, in rare cases, epithelial cell proliferation may accompany DN. We experienced a case of nodular diabetic glomerulosclerosis with marked extra-capillary hypercellularity and revealed the origin of this atypical lesion using immunostainings.

Case presentation

A man in his 50 s was admitted to the hospital with nephrotic syndrome, and a renal biopsy was performed. Diffuse nodular lesions and extra-capillary hypercellularity were observed, but the results of serological examination or immunofluorescent assays did not implicate any other crescentic GN. Immunostaining for claudin-1 and nephrin was performed to identify the origin of the extra-capillary lesions. Given the clinical course and pathological findings, a diagnosis of DN-associated extra-capillary cell proliferation was made.

Conclusions

Extra-capillary hypercellularity, which resembles FSGS or crescentic GN, is a rare finding in DN and should therefore be treated with caution. In such cases, co-staining for claudin-1 and nephrin may facilitate the diagnosis of DN.
Birth-related posttraumatic stress disorder and negative childbirth experience related to maternal functioning among adolescent mothers: a cross-sectional study
Authors: Vahidi Fereshteh , Mirghafourvand Mojgan , Naseri Elaheh , Ghanbari-Homaie Solmaz
Published: May 2023

Background

Adolescent pregnancy is an important issue in terms of reproductive health. Adolescent mothers have to overcome two crises at the same time: motherhood and maturity. Childbirth experience and posttraumatic stress disorder may influence the mother’s perception of her infant and postpartum care behaviors.

Methods

This cross-sectional study was conducted on 202 adolescent mothers referring to health centers in Tabriz and its suburbs between May and December, 2022. Data were collected by PTSD Symptom Scale, Childbirth Experience Questionnaire 2.0, and Barkin Index of Maternal Functioning. The association between childbirth experience, posttraumatic stress disorder and maternal functioning was assessed by multivariate analysis.

Results

After adjusting the effect of socio-demographic and obstetric characteristics, the score of maternal functioning among mothers without posttraumatic stress disorder was statistically significantly higher than mothers with posttraumatic stress disorder diagnosis [β (95% CI) = 2.30 (0.39 to 4.20); p = 0.031]. The score of maternal functioning increased with the increase in the childbirth experience score [β (95% CI) = 7.34 (3.87 to 10.81); p < 0.001]. The score of maternal functioning among mothers with wanted sex of baby was statistically significantly higher than unwanted sex of baby [β (95% CI) = 2.70 (0.37 to 5.02); p = 0.023].

Conclusion

Healthcare professionals should pay special attention to improving maternal functioning among adolescent mothers. One of the important actions can be to create a positive experience of childbirth for avoiding of posttraumatic stress disorder following birth and counseling with mothers who stated sex of fetus is undesired.
Cornea opacity, uveitis with iris atrophy and lens damage following cosmetic high-intensity ultrasound of the eyelid: a case report
Authors: Marafon Samara Barbara , Marinho Diane Ruschel , Kwitko Sérgio
Published: May 2023

Background

High-intensity focused ultrasound (HIFU) is a cosmetic procedure that aims to tone the skin through thermal collagen coagulation. The energy is delivered in the deep layers of the skin, and because of these characteristics, the risks of severe damage to adjacent tissue and the ocular surface may be underestimated. Previous reports have demonstrated superficial corneal opacities, cataracts, increased intraocular pressure, or ocular refractive changes in different patients following HIFU. In this case, we report deep stromal opacities associated with anterior uveitis, iris atrophy and lens opacity formation following a single HIFU superior eyelid application.

Case presentation

A 47-year-old female presented to the ophthalmic emergency department complaining of pain, hyperemia and photophobia in the right eye following a HIFU application to the superior right eyelid. A slit lamp examination showed three temporal-inferior corneal infiltrates with edema and severe anterior uveitis. The patient was treated with topical corticosteroids, and six months later, there was residual corneal opacity, iris atrophy and peripherical cataract formation. No surgical procedure was needed, and the final vision was Snellen 20/20 (1.0).

Conclusion

The risk of severe impairment to the ocular surface and ocular tissues may be underestimated. Cosmetic surgeons and ophthalmologists must be aware of the complications, and the long-term follow-up of these changes needs further investigation and discussion. Safety protocols of the HIFU intensity threshold for thermal lesions in the eye and the use of protective eye devices should be better evaluated.
Unilateral hypertensive choroidopathy as a sole manifestation in malignant hypertension: optical coherence tomography angiography findings-case report
Authors: Karagiannis Dimitrios , Bouratzis Nikolaos , Kontomichos Loukas , Pantazis Panagiotis , Kandarakis Stylianos , Paroikakis Efstratios
Published: May 2023

Background

We present a case of hypertensive choroidopathy due to malignant hypertension with exudative retinal detachment as a sole finding. We use OCT- angiography for initial diagnosis and report findings from extensive follow up.

Case presentation

A 51-year-old female with no past medical history, presented to our clinic with painless loss of vision in her left eye. Fundus examination revealed only exudative retinal detachment in her left eye that was confirmed with Optical Coherence Tomography. Fluorescein angiography showed hyperfluorescent spots with leakage in late phases. OCTA manifested a focal dark area in the choriocapillaris slab corresponding to flow signal voids, signifying regions of non-perfusion. Her blood pressure was 220/120 mmHG. Complete blood work -up failed to reveal any other possible etiology. During follow-up period of 9 months blood pressure normalized, patient regained visual function and choriocapillaris perfusion was completely restored.

Discussions and conclusions

Hypertensive choroidopathy with exudative retinal detachment can be the only sign of malignant hypertension and no pre-existing history of a systemic disease is required in order to become apparent. OCTA reveals areas of non-perfusion at choriocapillaris level, proving that it is an essential tool in the diagnosis and follow up of patients with hypertensive choroidopathy. Finally, we propose that early diagnosis prevents permanent damage of the RPE and leads to complete choroidal remodeling and better visual outcomes.
Spatial heterogeneity of socio-economic determinants of typhoid/paratyphoid fever in one province in central China from 2015 to 2019
Authors: Ren Xiang , Zhang Siyu , Luo Piaoyi , Zhao Jin , Kuang Wentao , Ni Han , Zhou Nan , Dai Haoyun , Hong Xiuqin , Yang Xuewen , Zha Wenting , Lv Yuan
Published: May 2023

Background

Typhoid fever and paratyphoid fever are one of the most criticial public health issues worldwide, especially in developing countries. The incidence of this disease may be closely related to socio-economic factors, but there is a lack of research on the spatial level of relevant determinants of typhoid fever and paratyphoid fever.

Methods

In this study, we took Hunan Province in central China as an example and collected the data on typhoid and paratyphoid incidence and socio-economic factors in 2015–2019. Firstly spatial mapping was made on the disease prevalence, and again using geographical probe model to explore the critical influencing factors of typhoid and paratyphoid, finally employing MGWR model to analysis the spatial heterogeneity of these factors.

Results

The results showed that the incidence of typhoid and paratyphoid fever was seasonal and periodic and frequently occurred in summer. In the case of total typhoid and paratyphoid fever, Yongzhou was the most popular, followed by Xiangxi Tujia and Miao Autonomous Prefecture, Huaihua and Chenzhou generally focused on the south and west. And Yueyang, Changde and Loudi had a slight increase trend year by year from 2015 to 2019. Moreover, the significant effects on the incidence of typhoid and paratyphoid fever from strong to weak were as follows: gender ratio(q = 0.4589), students in ordinary institutions of higher learning(q = 0.2040), per capita disposable income of all residents(q = 0.1777), number of foreign tourists received(q = 0.1697), per capita GDP(q = 0.1589), and the P values for these factors were less than 0.001. According to the MGWR model, gender ratio, per capita disposable income of all residents and Number of foreign tourists received had a positive effect on the incidence of typhoid and paratyphoid fever. In contrast, students in ordinary institutions of higher learning had a negative impact, and per capita GDP shows a bipolar change.

Conclusions

The incidence of typhoid and paratyphoid fever in Hunan Province from 2015 to 2019 was a marked seasonality, concentrated in the south and west of Hunan Province. Attention should be paid to the prevention and control of critical periods and concentrated areas. Different socio-economic factors may show other directions and degrees of action in other prefecture-level cities. To summarize, health education, entry-exit epidemic prevention and control can be strengthened. This study may be beneficial to carry out targeted, hierarchical and focused prevention and control of typhoid fever and paratyphoid fever, and provide scientific reference for related theoretical research.
Periodontal and peri-implant status and whole salivary interleukin 1-beta levels among individuals using selective serotonin reuptake inhibitors: an observational study
Authors: ALHarthi Shatha Subhi , BinShabaib Munerah S. , Alwahibi Abdulrahman , Gamal Shahinaz , Elashiry Eldin , Almershed Sarah E. , Alkhamis Haifa Abdulrahman , Anweigi Lamyia
Published: May 2023

Objective

Selective serotonin reuptake inhibitors (SSRI) are commonly used for managing psychological diseases such as depression. These disorders are also directly associated with periodontal and peri-implant diseases, namely periodontitis and peri-implantitis, respectively. It is hypothesized that there is no difference in periodontal and peri-implant clinicoradiographic status and unstimulated whole salivary interleukin (IL)-1β levels in participants using selective serotonin reuptake inhibitors (SSRI) and controls (individuals not using SSRI). The aim of the present observational case-control study was to compare periodontal and peri-implant clinicoradiographic statuses and whole salivary IL-1β in participants using SSRI and controls.

Methods

Users of SSRI and controls were included. In all participants, periodontal (plaque index [PI], gingival index [GI], probing depth [PD], clinical attachment loss [AL] and marginal bone loss [MBL]) and peri-implant (modified PI [mPI], modified GI [mGI], PD and crestal bone loss [CBL]) were assessed. Unstimulated whole saliva was collected and IL-1β levels were determined. Information related to duration of implants in function, duration of depressive symptoms and treatment of depression was retrieved from healthcare records. Sample-size was estimated using 5% error and group comparisons were performed. P < 0.05 was considered statistically significant.

Results

Thirty-seven SSRI users and 35 controls were assessed. Individuals using SSRI had a history of depression of 4.2 ± 2.5 years. The mean age of SSRI-users and controls were 48.7 ± 5.7 and 45.3 ± 5.1 years, respectively. Tooth brushing twice daily was reported by 75.7% and 62.9% SSRI-users and controls, respectively. There was no statistically significant difference in PI, mPI, GI, mGI, PD, clinical AL, numbers of MT and mesial and distal MBL and CBL among individuals using SSRI compared with controls (Tables 3 and 4). The unstimulated whole salivary flow rate in individuals using SSRI and controls was 0.11 ± 0.003 and 0.12 ± 0.001 ml/min, respectively. Whole salivary IL-1β levels in individuals using SSRI and controls were 57.6 ± 11.6 pg/ml and 34.6 ± 5.2 pg/ml, respectively.

Conclusion

Users of SSRI and controls demonstrate healthy periodontal and peri-implant tissue statuses with no marked differences in whole salivary IL-1β levels provided oral hygiene is stringently maintained.
Digital encounter decision aids linked to clinical practice guidelines: results from user testing SHARE-IT decision aids in primary care
Authors: Van Bostraeten Pieter , Aertgeerts Bert , Bekkering Geertruida , Delvaux Nicolas , Haers Anna , Vanheeswyck Matisse , Vandekendelaere Alexander , Van der Auwera Niels , Dijckmans Charlotte , Ostyn Elise , Soontjens Willem , Matthysen Wout , Schenk Noémie , Mertens Lien , Jaeken Jasmien , Agoritsas Thomas , Vermandere Mieke
Published: May 2023

Background

Encounter decision aids (EDAs) are tools that can support shared decision making (SDM), up to the clinical encounter. However, adoption of these tools has been limited, as they are hard to produce, to keep up-to-date, and are not available for many decisions. The MAGIC Evidence Ecosystem Foundation has created a new generation of decision aids that are generically produced along digitally structured guidelines and evidence summaries, in an electronic authoring and publication platform (MAGICapp). We explored general practitioners’ (GPs) and patients' experiences with five selected decision aids linked to BMJ Rapid Recommendations in primary care.

Methods

We applied a qualitative user testing design to evaluate user experiences for both GPs and patients. We translated five EDAs relevant to primary care, and observed the clinical encounters of 11 GPs when they used the EDA with their patients. We conducted a semi-structured interview with each patient after the consultation and a think-aloud interview with each GPs after multiple consultations. We used the Qualitative Analysis Guide (QUAGOL) for data analysis.

Results

Direct observations and user testing analysis of 31 clinical encounters showed an overall positive experience. The EDAs created better involvement in decision making and resulted in meaningful insights for patients and clinicians. The design and its interactive, multilayered structure made the tool enjoyable and well-organized. Difficult terminology, scales and numbers hindered understanding of certain information, which was sometimes perceived as too specialized or even intimidating. GPs thought the EDA was not suitable for every patient. They perceived a learning curve was required and the need for time investment was a concern. The EDAs were considered trustworthy as they were provided by a credible source.

Conclusions

This study showed that EDAs can be useful tools in primary care by supporting actual shared decision making and enhancing patient involvement. The graphical approach and clear representation help patients better understand their options. To overcome barriers such as health literacy and GPs attitudes, effort is still needed to make the EDAs as accessible, intuitive and inclusive as possible through use of plain language, uniform design, rapid access and training.

Trial registration

The study protocol was approved by the The Research Ethics Committee UZ/KU Leuven (Belgium) on 31–10-2019 with reference number MP011977.
S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy
Authors: Qi Mengxin , Yi Xianglan , Yue Baohui , Huang Mingxiang , Zhou Sheng , Xiong Jing
Published: May 2023

Background

S100A6 and murine double minute 2 (MDM2) are important cancer-related molecules. A previous study identified an interaction between S100A6 and MDM2 by size exclusion chromatography and surface plasmon resonance experiments. The present study investigated whether S100A6 could bind to MDM2 in vivo and further explored its functional implication.

Methods

Co-immunoprecipitation, glutathione-S-transferase pull-down assay, and immunofluorescence were performed to determine the in vivo interaction between S100A6 and MDM2. Cycloheximide pulse-chase assay and ubiquitination assay were performed to clarify the mechanism by which S100A6 downregulated MDM2. In addition, clonogenic assay, WST-1 assay, and flow cytometry of apoptosis and the cell cycle were performed and a xenograft model was established to evaluate the effects of the S100A6/MDM2 interaction on growth and paclitaxel-induced chemosensitivity of breast cancer. The expressions of S100A6 and MDM2 in patients with invasive breast cancer were analyzed by immunohistochemistry. In addition, the correlation between the expression of S100A6 and the response to neoadjuvant chemotherapy was statistically analyzed.

Results

S100A6 promoted the MDM2 translocation from nucleus to cytoplasm, in which the S100A6 bound to the binding site of the herpesvirus-associated ubiquitin-specific protease (HAUSP) in MDM2, disrupted the MDM2–HAUSP–DAXX interactions, and induced the MDM2 self-ubiquitination and degradation. Furthermore, the S100A6-mediated MDM2 degradation suppressed the growth of breast cancer and enhanced its sensitivity to paclitaxel both in vitro and in vivo. For patients with invasive breast cancer who received epirubicin and cyclophosphamide followed by docetaxel (EC-T), expressions of S100A6 and MDM2 were negatively correlated, and high expression of S100A6 suggested a higher rate of pathologic complete response (pCR). Univariate and multivariate analyses showed that the high expression of S100A6 was an independent predictor of pCR.

Conclusion

These results reveal a novel function for S100A6 in downregulating MDM2, which directly enhances sensitivity to chemotherapy.
Management of dyspepsia and Helicobacter pylori infection: the 2022 Indonesian Consensus Report
Authors: Syam Ari Fahrial , Miftahussurur Muhammad , Makmun Dadang , Abdullah Murdani , Rani Abdul Aziz , Siregar Gontar Alamsyah , Simadibrata Marcellus , Zubir Nasrul , Dewa Nyoman Wibawa I. , Purnomo Hery Djagat , Manan Chudahman , Djojoningrat Dharmika , Fauzi Achmad , Renaldi Kaka , Maulahela Hasan , Utari Amanda Pitarini , Pribadi Rabbinu Rangga , Muzellina Virly Nanda , Nursyirwan Saskia Aziza , Idrus Muhammad Firhat , Ruswhandi Ruswhandi , Sugihartono Titong , Bestari Muhammad Begawan , Bayupurnama Putut , Pramana Triyanta Yuli , Wibowo Bogi Pratomo , Bakry Achmad Fuad , Akil Fardah , Parewangi Andi Muhammad Luthfi , Widita Haris , Mariadi I Ketut , Murti Ignatia Sinta , Yusuf Ali Imron , Arles Arles , Yusuf Fauzi , Waleleng Bradley Jimmy , Abimanyu Abimanyu , Mulyadi Yustar , Lucida Maria Inge , Rezkhita Yudith Annisa Ayu , Alfaray Ricky Indra , Yamaoka Yoshio
Published: May 2023

Dyspepsia still becomes a major challenge in upper gastrointestinal disease in Indonesia. This disease often correlated with Helicobacter pylori infection. However, the prevalence of this bacterium is generally low in Indonesia. Therefore, several considerations should be taken into consideration during the management of dyspepsia and H. pylori infection. “Management of dyspepsia and H. pylori infection in Indonesia: The Indonesian consensus report” comprises information gathered from 22 gastroenterology centers across Indonesia. The experts gathered to evolve a consensus, that consists of the statements, grades of recommendations, evidence levels, and rationales for the dyspepsia and H. pylori infection management for daily clinical practice. The report explains several aspects from the updated epidemiology information to comprehensive management therapy. After the experts worked together on all statements in the recommendations, the results are presented with the final agreement as a consensus to help clinicians in understanding, diagnosing, and treating dyspepsia and H. pylori infection patients in daily clinical practice in Indonesia.
TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype–phenotype correlation
Authors: Guan Yuqing , Liang Xiongda , Li Wei , Lin Wanying , Liang Guanxia , Xie Hongting , Hou Yu , Hu Yafang , Shang Xuan
Published: May 2023

Background

Limb-girdle muscular dystrophy R8 (LGMD R8) is a rare autosomal recessive muscle disease caused by TRIM32 gene biallelic defects. The genotype–phenotype correlation of this disease has been reported poorly. Here, we report a Chinese family with two female LGMD R8 patients.

Methods

We performed whole-genome sequencing (WGS) and Sanger sequencing on the proband. Meanwhile, the function of mutant TRIM32 protein was analyzed by bioinformatics and experimental analysis. In addition, a summary of the reported TRIM32 deletions and point mutations and an investigation of genotype–phenotype correlation were performed through a combined analysis of the two patients and other cases reported in previous literature.

Results

The two patients displayed typical symptoms of LGMD R8, which worsened during pregnancy. Genetic analysis by whole-genome sequencing (WGS) and Sanger sequencing showed that the patients were compound heterozygotes of a novel deletion (chr9.hg19:g.119431290_119474250del) and a novel missense mutation (TRIM32:c.1700A > G, p.H567R). The deletion encompassed 43 kb and resulted in the removal of the entire TRIM32 gene. The missense mutation altered the structure and further affected function by interfering with the self-association of the TRIM32 protein. Females with LGMD R8 showed less severe symptoms than males, and patients carrying two mutations in NHL repeats of the TRIM32 protein had earlier disease onset and more severe symptoms than other patients.

Conclusions

This research extended the spectrum of TRIM32 mutations and firstly provided useful data on the genotype–phenotype correlation, which is valuable for the accurate diagnosis and genetic counseling of LGMD R8.
Progress and application of the synthesis of trans-oceanic tsunamis
Authors: Watada Shingo
Published: May 2023

Abundant high-quality distant tsunami records from the 2010 Maule (Chile) and 2011 Tohoku-Oki earthquakes have revealed two distinctive features compared to long-wave tsunami simulations. The records show that the traveltime delay of the tsunami increases with distance from the earthquakes, and the initial phase reversal of tsunamis appears and grows systematically. The conventional tsunami theory cannot explain the observed waveforms and traveltimes of distant tsunamis, leading to the need for a new theory to explain and synthesize distant tsunamis. The propagating elevated sea surface of a tsunami compresses seawater and deforms the seafloor and the solid Earth. A propagating tsunami changes the mass distribution of the Earth and results in a spatiotemporal change in gravity, thereby altering the propagating tsunami itself. Incorporating these physics, we developed a new tsunami propagation theory in which a tsunami is naturally treated as a wave in a gravitationally and elastically coupled Earth system composed of solid Earth layers and an ocean layer. Two distinct tsunami simulation techniques based on the new tsunami propagation theory were introduced and confirmed to produce nearly identical tsunami waveforms. One technique treats tsunamis as free waves within a deformable Earth system, while the other treats tsunamis as external pressure and gravitational forces acting on the surface of a deformable Earth system. With the new techniques, the waveform and traveltime differences between the observed and simulated distant tsunamis disappear. Past distant tsunamis recorded by coastal tide gauges, which were not previously studied due to the traveltime and waveform mismatch problems, have become the focus of quantitative tsunami studies analyzing waveforms. New tsunami propagation techniques have been applied to the analysis of distant tsunami waveforms from the past 19 events and have helped to unveil the slip distributions of the past large earthquakes and to determine the earthquake origin time of the trans-Pacific tsunami events recorded by tide gauges since 1854.
Gender in mathematics: how gender role perception influences mathematical capability in junior high school
Authors: Xie Guihua , Liu Xinyu
Published: May 2023

Based on the China Education Panel Survey, this study discusses how gender role perception influences the mathematical capability of female students from the multilevel perspectives of individual, family, school, and region. This study finds that the stereotypical view of gender roles held by students and parents has a significant impact on the mathematical capability of both sexes, with a positive effect on male students and a negative effect on female students. However, the threat of gender stereotypes does not have a negative impact on female students. In addition, the number and sex of children in the family and the local sex ratio have no significant impact on the mathematical capability of either male or female students. Therefore, the major factors affecting ‘females’ mathematics learning are the stereotypical views of the relationship between gender and mathematics held by female students and families rather than the tradition of favoring men over women.
A landscape assessment of the activities and capacities of evidence-to-policy intermediaries (EPI) in behavioral health
Authors: Almquist Lars , Walker Sarah Cusworth , Purtle Jonathan
Published: May 2023

Background

A significant gap exists between the production of research evidence and its use in behavioral health policymaking. Organizations providing consulting and support activities for improving policy represent a promising source for strengthening the infrastructure to address this gap. Understanding the characteristics and activities of these evidence-to-policy intermediary (EPI) organizations can inform the development of capacity-building activities, leading to strengthened evidence-to-policy infrastructure and more widespread evidence-based policymaking.

Methods

Online surveys were sent to 51 organizations from English-speaking countries involved in evidence-to-policy activities in behavioral health. The survey was grounded in a rapid evidence review of the academic literature regarding strategies used to influence research use in policymaking. The review identified 17 strategies, which were classified into four activity categories. We administered the surveys via Qualtrics and calculated the descriptive statistics, scales, and internal consistency statistics using R.

Results

A total of 31 individuals completed the surveys from 27 organizations (53% response rate) in four English-speaking countries. EPIs were evenly split between university (49%) and non-university (51%) settings. Nearly all EPIs conducted direct program support (mean = 4.19/5 [sd = 1.25]) and knowledge-building (4.03 [1.17]) activities. However, engagement with traditionally marginalized and non-traditional partners (2.84 [1.39]) and development of evidence reviews using formal critical appraisal methods (2.81 [1.70]) were uncommon. EPIs tend to be specialized, focusing on a group of highly related strategies rather than incorporating multiple evidence-to-policy strategies in their portfolios. Inter-item consistency was moderate to high, with scaleα’s ranging from 0.67 to 0.85. Ratings of respondents’ willingness to pay for training in one of three evidence dissemination strategies revealed high interest in program and policy design.

Conclusions

Our results suggest that evidence-to-policy strategies are frequently used by existing EPIs; however, organizations tend to specialize rather than engage in a breadth of strategies. Furthermore, few organizations reported consistently engaging with non-traditional or community partners. Focusing on building capacity for a network of new and existing EPIs could be a promising strategy for growing the infrastructure needed for evidence-informed behavioral health policymaking.
Nonlocal interaction enhanced biexciton emission in large CsPbBr3 nanocrystals
Authors: Huang Peng , Sun Shipei , Lei Hairui , Zhang Yongyou , Qin Haiyan , Zhong Haizheng
Published: May 2023

Biexciton emission in quantum dots is an efficient way to generate entangled photon pairs, which are key resources in quantum informatics. Compared with epitaxial grown quantum dots, chemically synthesized colloidal quantum dots show advantages of tunable wavelength and easy integration to realize quantum light sources. However, biexciton efficiency of colloidal quantum dots has been limited by Auger recombination. In this paper, we reported nonlocal interaction enhanced biexciton emission with efficiency up to 80% in large perovskite nanocrystals (> 20 nm). The nonlocal interaction between carriers and excitons leads to the abnormal exponential decrease of Auger recombination with volume in large nanocrystals, which distinguishes with the linear scaling in small counterparts. Such an exponential decrease of Auger recombination results in long lifetime of biexcitons, responsible for the required high biexciton efficiency. The discovery of nonlocal effects in large semiconductor nanocrystals provides new strategies to achieve high efficiency multiple excitons for quantum optics and energy conversation applications.
Gaussian-weighted crosscorrelation imaging condition for microseismic source localization
Authors: Yang Peng , Gajewski Dirk , Xie Yujiang
Published: May 2023

Time-reversal imaging is a powerful method for the localization of microseismic events. Conventional time-reversal imaging methods such as autocorrelation imaging or grouped crosscorrelation imaging may suffer from imaging artifacts, e.g., caused by less refined velocity models, noise-contaminated data, and data acquired from sparse receiver networks. These artifacts typically reduce imaging quality and may cause subsequent misinterpretations leading to false positives. To address these issues, we develop a new imaging condition that comprises three steps for each time step. First, we divide the back-propagated wavefield into parts according to their maximum absolute amplitudes. Second, the amplitudes of the back-propagated wavefield are weighted by a Gaussian function with the spatial extent of the prevailing wavelength of the event, centered at the absolute maximum of that part of the wavefield. Finally, we zero-lag crosscorrelate these weighted wavefields at each space point to obtain an image for this time step. The final image is gained by summing the images for each time step. This process collects all energy concentrations along the back projection process, and the energy on the wavefront overlaps and collapses at the hypocenter leading to high-resolution images displaying little to no imaging artifacts. Numerical examples using the Marmousi-II and the 3D SEG overthrust models and a 3D field data example indicate the performance of our method. High-resolution low-noise source images allow unique identification of sources even for source clusters, noisy data, and sparse acquisitions. The source localization errors are smaller than the dominant wavelength of the signal, where a smooth model with a mean velocity error of approximately 5% was considered in the synthetic examples, and a homogeneous model was used in the field data example.
Clinical Outcomes and Prognostic Factors of Patients With Early Malignant Melanoma in One Latin American Country: Results of the Epidemiological Registry of Malignant Melanoma in Colombia Study
Authors: Ospina Serrano Aylen Vanessa , Contreras Fernando , Triana Iván , Sánchez-Vanegas Guillermo , Ortíz Juan David , Ramos Pedro , Vargas Claudia , Arango Natalia , Idrobo Henry , Munévar Isabel , Yepes Andrés , Mantilla William , Jiménez Paola , Rivas Giovanna , Lema Mauricio , Alcalá Carmen , Gómez Diego , Chinchia Matilde , Barrero Angela
Published: May 2023

To describe the population with early malignant melanoma, we performed a cohort study on the basis of the Epidemiological Registry of Malignant Melanoma in Colombia-Asociacion Colombiana de Hematologia y Oncologia. From January 2011 until December 2021, 759 patients were included; the average age was 66 years, 57% were women, acral lentiginous histology was found in 27.8% of patients, and the median follow-up was 36.5 months. The prognostic factors for overall survival in our population are Eastern Cooperative Oncology Group 3-4 (hazard ratio [HR], 13.8), stage III (HR, 5.07), received radiotherapy (HR, 3.38), ulceration on histology (HR, 2.68), chronic sun exposure (HR, 2.3), low income (HR, 2.04), previous local surgery (HR, 0.27), and have received adjuvant treatment (HR, 0.41).
Cervical Cancer Progression in Patients Waiting for Radiotherapy Treatment at a Referral Center in Ethiopia: A Longitudinal Study
Authors: Feyisa Jilcha D. , Woldegeorgis Mathewos A. , Zingeta Girum T. , Abegaz Kedir H. , Berhane Yemane
Published: May 2023

PURPOSE

Nonmetastatic cervical cancer is curable and can be treated with radiotherapy (RT). A delay in receiving treatment because of long waiting times results in upstaging of the disease stage and negatively affects the treatment outcomes. However, real-world evidence that progression occurs while waiting for treatment is scarce in low-income countries. We evaluated the impact of long waiting times for RT in patients with cervical cancer at a referral center in Ethiopia.

METHODS

A longitudinal study was conducted from January 5, 2019, to May 30, 2020, to address the objectives of this study. Patients with pathologically diagnosed cervical cancer with stage IIB to stage IVA were included in the study. We used Kaplan-Meier analysis to assess overall survival with time. Multivariate Cox regression analysis, using the backward likelihood ratio selection method, was used to fit the final model.

RESULTS

The median waiting time for radical RT after diagnosis was 477 days. Waiting for more than 51 days for RT results in disease progression. Of the 115 patients included in this study, 59 (51.3%) died during the study period. A delay in waiting (adjusted hazard ratio, 3; 95% CI, 1.7 to 4.9) was significantly associated with disease progression and decreased survival.

CONCLUSION

Waiting time to receive RT is very long. Urgent action is required to significantly reduce waiting times and improve the survival of patients with cervical cancer.
Accumulation of Chronic Disease Among Survivors of Childhood Cancer Predicts Early Mortality
Authors: Esbenshade Adam J. , Lu Lu , Friedman Debra L. , Oeffinger Kevin C. , Armstrong Gregory T. , Krull Kevin R. , Neglia Joseph P. , Leisenring Wendy M. , Howell Rebecca , Partin Robyn , Sketch Amy , Robison Leslie L. , Ness Kirsten K.
Published: May 2023

PURPOSE

Cancer survivors develop cancer and treatment-related morbidities at younger than normal ages and are at risk for early mortality, suggestive of an aging phenotype. The Cumulative Illness Rating Scale for Geriatrics (CIRS-G) is specifically designed to describe the accumulation of comorbidities over time with estimates of severity such as total score (TS) which is a sum of possible conditions weighted by severity. These severity scores can then be used to predict future mortality.

METHODS

CIRS-G scores were calculated in cancer survivors and their siblings from Childhood Cancer Survivor Study cohort members from two time points 19 years apart and members of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004. CIRS-G metrics were analyzed using Cox proportional hazards regression to determine subsequent mortality risk.

RESULTS

In total, 14,355 survivors with a median age of 24 (IQR, 18-30) years and 4,022 siblings with a median age of 26 (IQR, 19-33) years provided baseline data; 6,138 survivors and 1,801 siblings provided follow-up data. Cancer survivors had higher median baseline TS than siblings at baseline (5.75 v 3.44) and follow-up (7.76 v 4.79), all P < .01. The mean increase in TS from baseline to follow-up was significantly steeper in cancer survivors (2.89 males and 3.18 females) vs. siblings (1.79 males and 1.69 females) and NHANES population (2.0 males and 1.94 females), all P < .01. Every point increase in baseline TS increased hazard for death by 9% (95% CI, 8 to 10) among survivors.

CONCLUSION

Application of a geriatric rating scale to characterize disease supports the hypothesis that morbidity accumulation is accelerated in young adult survivors of childhood cancer when compared with siblings and the general population.
Musica Practica: The Sound of the Beijing New Worker Band
Authors: Zhong Yurou
Published: May 2023

Since its inception in 2002, the Beijing New Worker Band has become a representative art group formed by and dedicated to migrant workers. Changing its name three times in twenty years, the band has demonstrated a strong capacity to adapt to uncertain political tides, subsisting in the exploration and expression of art and culture with a new working-class consciousness in postsocialist China. The status of the group has been bolstered by an array of artistic output, such as theater productions, literary writings, and Spring Festival galas. Although overshadowed by some of the better publicized, more successful creative activities, music has been the group's steadiest form of self-expression. Appropriating Roland Barthes's concept of musica practica, this article interrogates the unique status that music has enjoyed in this group and explores three interrelated aspects—album writing, live performances, and community and relationship building—with an emphasis on “practice.” It investigates how musica practica constitutes a pivotal mechanism that enables the group to form and transform as main stakeholders in the making of the new working class, and to imagine and experiment with what cultures of labor in the twenty-first century could sound like.
Revolutionary Feminists
Authors: Winslow Barbara
Published: May 2023

Revolutionary Feminists tells the story of the radical women’s liberation movement in Seattle in the 1960s and 1970s from the perspective of a founding member, Barbara Winslow. Drawing on her collection of letters, pamphlets, and photographs as well as newspaper accounts, autobiographies, and interviews, Winslow emphasizes the vital role that Black women played in the women’s liberation movement to create meaningful intersectional coalitions in an overwhelmingly White city. Winslow brings the voices and visions of those she calls the movement’s “ecstatic utopians” to life. She charts their short-term successes and lasting achievements, from organizing women at work and campaigning for subsidized childcare to creating women-centered rape crisis centers, health clinics, and self-defense programs. The Seattle movement was essential to winning the first popular vote in the United States to liberalize abortion laws. Despite these achievements, Winslow critiques the failure of the movement's White members to listen to Black, Latina, Indigenous, and Asian American and Pacific Islander feminist activists. Reflecting on the Seattle movement’s accomplishments and shortcomings, Winslow offers a model for contemporary feminist activism.
Genomics with Care
Authors: Fortun Mike
Published: May 2023

In Genomics with Care Mike Fortun presents an experimental ethnography of contemporary genomics, analyzing science as a complex amalgam of cognition and affect, formal logics and tacit knowledge, statistics, and ethics. Fortun examines genomics in terms of care—a dense composite of affective and cognitive forces that drive scientists and the relations they form with their objects of research, data, knowledge, and community. Reading genomics with care shows how each resists definition yet is so entangled as to become indistinguishable. Fortun analyzes four patterns of genomic care—curation, scrupulousness, solicitude, and friendship—seen in the conceptual, technological, social, and methodological changes that transpired as the genetics of the 1980s became the genomics of the 1990s, and then the “post-genomics” of the 2000s. By tracing the dense patterns made where care binds to science, Fortun shows how these patterns mark where scientists are driven to encounter structural double binds that are impossible to resolve, and yet are where scientific change and creativity occur.