bluuebunny/crossref_metadata_2025 huggingface dataset:
Micromolar Valproic Acid Doses Preserve Survival and Induce Molecular Alterations in Neurodevelopmental Genes in Two Strains of Zebrafish Larvae
Authors: Messina Andrea , Boiti Alessandra , Sovrano Valeria Anna , Sgadò Paola
Published: September 2020

Autism spectrum disorders (ASDs) comprise a genetically heterogeneous group of conditions characterized by a multifaceted range of impairments and multifactorial etiology. Epidemiological studies have identified valproic acid (VPA), an anticonvulsant used to treat epilepsy, as an environmental factor for ASDs. Based on these observations, studies using embryonic exposure to VPA have been conducted in many vertebrate species to model ASD. The zebrafish is emerging as a popular model in biomedical research to study the molecular pathways involved in nervous system disorders. VPA exposure in zebrafish larvae has been shown to produce a plethora of effects on social, motor and anxiety behavior, and several genetic pathways altered by VPA have been described. However, the doses and regimen of administration reported in the literature are very heterogenous, creating contradictory results and posing serious limits to the interpretation of VPA action on neurodevelopment. To shed light on the toxic effect of VPA, we tested micromolar concentrations of VPA, using exposure for 24 and 48 h in two different zebrafish strains. Our results show that micromolar doses of VPA mildly affect embryo survival but are sufficient to induce molecular alterations in neurodevelopmental genes previously shown to be influenced by VPA, with substantial differences between strains.
Nanofluidic Immobilization and Growth Detection of Escherichia coli in a Chip for Antibiotic Susceptibility Testing
Authors: Busche Jan , Möller Svenja , Klein Ann-Kathrin , Stehr Matthias , Purr Foelke , Bassu Margherita , Burg Thomas , Dietzel Andreas
Published: September 2020

Infections with antimicrobial resistant bacteria are a rising threat for global healthcare as more and more antibiotics lose their effectiveness against bacterial pathogens. To guarantee the long-term effectiveness of broad-spectrum antibiotics, they may only be prescribed when inevitably required. In order to make a reliable assessment of which antibiotics are effective, rapid point-of-care tests are needed. This can be achieved with fast phenotypic microfluidic tests, which can cope with low bacterial concentrations and work label-free. Here, we present a novel optofluidic chip with a cross-flow immobilization principle using a regular array of nanogaps to concentrate bacteria and detect their growth label-free under the influence of antibiotics. The interferometric measuring principle enabled the detection of the growth of Escherichia coli in under 4 h with a sample volume of 187.2 µL and a doubling time of 79 min. In proof-of-concept experiments, we could show that the method can distinguish between bacterial growth and its inhibition by antibiotics. The results indicate that the nanofluidic chip approach provides a very promising concept for future rapid and label-free antimicrobial susceptibility tests.
Performance Evaluation of Satellite-Based Rainfall Products over Nigeria
Authors: Ogbu Kingsley N. , Hounguè Nina Rholan , Gbode Imoleayo E. , Tischbein Bernhard
Published: September 2020

Understanding the variability of rainfall is important for sustaining rain-dependent agriculture and driving the local economy of Nigeria. Paucity and inadequate rain gauge network across Nigeria has made satellite-based rainfall products (SRPs), which offer a complete spatial and consistent temporal coverage, a better alternative. However, the accuracy of these products must be ascertained before use in water resource developments and planning. In this study, the performances of Climate Hazards Group Infrared Precipitation with Station data (CHIRPS), Precipitation estimation from Remotely Sensed Information using Artificial Neural Networks–Climate Data Record (PERSIANN-CDR), and Tropical Applications of Meteorology using SATellite data and ground-based observations (TAMSAT), were evaluated to investigate their ability to reproduce long term (1983–2013) observed rainfall characteristics derived from twenty-four (24) gauges in Nigeria. Results show that all products performed well in terms of capturing the observed annual cycle and spatial trends in all selected stations. Statistical evaluation of the SRPs performance show that CHIRPS agree more with observations in all climatic zones by reproducing the local rainfall characteristics. The performance of PERSIANN and TAMSAT, however, varies with season and across the climatic zones. Findings from this study highlight the benefits of using SRPs to augment or fill gaps in the distribution of local rainfall data, which is critical for water resources planning, agricultural development, and policy making.
Modeling and Analysis of Barriers to Climate Change Adaptation in Tehran
Authors: Ghasemzadeh Behnam , Sharifi Ayyoob
Published: September 2020

Since the impacts of climate change will last for many years, adaptation to this phenomenon should be prioritized in urban management plans. Although Tehran, the capital of Iran, has been subject to a variety of climate change impacts in recent years, appropriate adaptation measures to address them are yet to be taken. This study primarily aims to categorize the barriers to climate change adaptation in Tehran and analyze the way they interact with each other. The study was done in three steps: first, the focus group discussion (FGD) method was used to identify the barriers; next, the survey and the structural equation modeling (SEM) were used to validate the barriers, identify their importance, and examine their possible inter-relationships; and finally, the interpretive structural modeling (ISM) was applied to categorize and visualize the relationships between the barriers. Results show that barriers related to the ‘structure and culture of research’, ‘laws and regulations’, and ‘planning’ belong to the cluster of independent barriers and are of greater significance. The ‘social’ barrier and barriers related to ‘resources and resource management’ are identified as dependent barriers and are of lesser importance. Barriers related to ‘governance’, ‘awareness’, ‘education and knowledge’, ‘communication and interaction’, and ‘economy’ are identified at the intermediate cluster. The findings of this study can provide planners and decision makers with invaluable insights as to how to develop strategies for climate change adaptation in Tehran. Despite the scope of the study being confined to Tehran, its implications go far beyond this metropolis.
A Rapid SARS-CoV-2 RT-PCR Assay for Low Resource Settings
Authors: Arumugam Arunkumar , Faron Matthew L. , Yu Peter , Markham Cole , Wu Michelle , Wong Season
Published: September 2020

Quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay is the gold standard recommended to test for acute SARS-CoV-2 infection. However, it generally requires expensive equipment such as RNA isolation instruments and real-time PCR thermal cyclers. As a pandemic, COVID-19 has spread indiscriminately, and many low resource settings and developing countries do not have the means for fast and accurate COVID-19 detection to control the outbreak. Additionally, long assay times, in part caused by slow sample preparation steps, have created a large backlog when testing patient samples suspected of COVID-19. With many PCR-based molecular assays including an extraction step, this can take a significant amount of time and labor, especially if the extraction is performed manually. Using COVID-19 clinical specimens, we have collected evidence that the RT-qPCR assay can feasibly be performed directly on patient sample material in virus transport medium (VTM) without an RNA extraction step, while still producing sensitive test results. If RNA extraction steps can be omitted without significantly affecting clinical sensitivity, the turn-around time of COVID-19 tests, and the backlog we currently experience can be reduced drastically. Furthermore, our data suggest that rapid RT-PCR can be implemented for sensitive and specific molecular diagnosis of COVID-19 in locations where sophisticated laboratory instruments are not available. Our USD 300 set up achieved rapid RT-PCR using thin-walled PCR tubes and a water bath setup using sous vide immersion heaters, a Raspberry Pi computer, and a single servo motor that can process up to 96 samples at a time. Using COVID-19 positive clinical specimens, we demonstrated that RT-PCR assays can be performed in as little as 12 min using untreated samples, heat-inactivated samples, or extracted RNA templates with our low-cost water bath setup. These findings can help rapid COVID-19 testing to become more accessible and attainable across the globe.
Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic Practice
Authors: Parente Paola , Covelli Claudia , Zanelli Magda , Trombetta Domenico , Carosi Illuminato , Carbonelli Cristiano , Sperandeo Marco , Mastracci Luca , Biancofiore Giovanni , Zizzo Maurizio , Taurchini Marco , Ascani Stefano , Graziano Paolo
Published: September 2020

Background: The diagnosis of lymphoma requires surgical specimens to perform morphological evaluation, immunohistochemical and molecular analyses. Ultrasound-guided fine needle aspiration may represent an appropriate first approach to obtain cytological samples in impalpable lesions and/or in patients unsuitable for surgical procedures. Although cytology has intrinsic limitations, the cell block method may increase the possibility of achieving an accurate diagnosis. Methods: We retrospectively selected a total of 47 ultrasound-guided fine needle aspiration and drainage samples taken from patients with effusion and deep-seated lesions which are clinically suspicious in terms of malignancy. Results: In 27 cases, both cell block and conventional cytology were performed: 21/27 cell blocks were adequate for the diagnosis of lymphoma and suitable for immunocytochemistry and molecular analyses vs. 12/20 samples to which only conventional cytology was applied. Moreover, in five patients we were able to make a diagnosis of Hodgkin lymphoma with the cell block (CB) technique. Conclusions: Contrary to conventional cytology, the cell block method may allow immunocytochemistry and molecular studies providing useful information for the diagnosis and subtypization of lymphoma in patients unsuitable for surgical procedure or with deep-seated lesions or extra-nodal diseases; additionally, it is a daily, simple and helpful approach. Moreover, we describe the usefulness of cell blocks in the diagnosis of Hodgkin lymphoma.
Competitive Conditions in Global Value Chain Networks: An Assessment Using Entropy and Network Analysis
Authors: Angelidis Georgios , Ioannidis Evangelos , Makris Georgios , Antoniou Ioannis , Varsakelis Nikos
Published: September 2020

We investigated competitive conditions in global value chains (GVCs) for a period of fifteen years (2000–2014), focusing on sector structure, countries’ dominance and diversification. For this purpose, we used data from the World Input–Output Database (WIOD) and examined GVCs as weighted directed networks, where countries are the nodes and value added flows are the edges. We compared the in-and out-weighted degree centralization of the sectoral GVC networks in order to detect the most centralized, on the import or export side, respectively (oligopsonies and oligopolies). Moreover, we examined the in- and out-weighted degree centrality and the in- and out-weight entropy in order to determine whether dominant countries are also diversified. The empirical results reveal that diversification (entropy) and dominance (degree) are not correlated. Dominant countries (rich) become more dominant (richer). Diversification is not conditioned by competitiveness.
Statistical Surveillance of Structural Breaks in Credit Rating Dynamics
Authors: Xing Haipeng , Wang Ke , Li Zhi , Chen Ying
Published: September 2020

The 2007–2008 financial crisis had severe consequences on the global economy and an intriguing question related to the crisis is whether structural breaks in the credit market can be detected. To address this issue, we chose firms’ credit rating transition dynamics as a proxy of the credit market and discuss how statistical process control tools can be used to surveil structural breaks in firms’ rating transition dynamics. After reviewing some commonly used Markovian models for firms’ rating transition dynamics, we present several surveillance rules for detecting changes in generators of firms’ rating migration matrices, including the likelihood ratio rule, the generalized likelihood ratio rule, the extended Shiryaev’s detection rule, and a Bayesian detection rule for piecewise homogeneous Markovian models. The effectiveness of these rules was analyzed on the basis of Monte Carlo simulations. We also provide a real example that used the surveillance rules to analyze and detect structural breaks in the monthly credit rating migration of U.S. firms from January 1986 to February 2017.
Design of Streaming Data Transmission Using Rolling Shutter Camera-Based Optical Camera Communications
Authors: Kim Byung Wook , Yoo Jong-Ho , Jung Sung-Yoon
Published: September 2020

This paper addresses a method to transmit streaming data via rolling shutter camera-based optical camera communications (OCC). Since the amount of data that can be contained within one frame is limited, and the continuity of received data cannot be guaranteed due to OCC environmental variations, we introduce the concept of dividing the streaming data into several fragmented sets that are transmitted sequentially. We propose a superframe to contain sequential packets of fragmented data and corresponding indices, so that sequential packets for streaming data can be continuously collected. When redundant frame transmission is considered, any packet lost due to OCC environmental conditions can be recovered. Experimental results show that the proposed method can be successfully used to transmit streaming data, with the number of redundant frames required to acquire all data packets based on image resolution. In addition, we describe how to identify missing packets from a network point of view to reduce the number of redundant frames needed to acquire all the data. This paper presents baseline results of communication performance when sending streaming data via a rolling shutter-based OCC.
A New Data-Driven Approach for Power IGBT Remaining Useful Life Estimation Based On Feature Reduction Technique and Neural Network
Authors: Ismail Adla , Saidi Lotfi , Sayadi Mounir , Benbouzid Mohamed
Published: September 2020

The insulated gate bipolar transistor (IGBT) is a crucial component of power converters (PCVs) and is commonly used in several PCVs topologies. On the other hand, the investigation and the study of the IGBT component show several changes within its behavior and lifetime, while this component is highly influenced by the operating conditions. Indeed, the monitoring of this component is necessary to minimize unexpected downtime of the wind energy system (WES). However, an accurate prediction of IGBTs remaining useful life (RUL) is the key enabler for life-time-optimized operation. Consequently, this work proposes a new prognostic approach for online IGBTs monitoring that adopts the time-domain analysis to extract useful information that is used as an input in the generation of the health indicator. Moreover, this approach is based on combining both of principal component analysis (PCA) technique and the feedforward neural network (FFNN) technique. PCA is used to reduce features extracted from IGBTs and the FFNN is implemented to achieve online regression of the trend parameter obtained from the PCA technique. To investigate and evaluate the performance of our idea we used the NASA Ames Laboratory Prognostics Center of Excellence IGBTs accelerated aging database. Finally, the achieved results clearly show the strength of the new trend parameter for IGBTs RUL prediction. The most notable strong correlation within the proposed approach is in relation to accuracy value, with an acceptable average accuracy rate of 60.4%.
Low Enthalpy Geothermal Resources for Local Sustainable Development: A Case Study in Poland
Authors: Szulc-Wrońska Aleksandra , Tomaszewska Barbara
Published: September 2020

Many regions in Poland face the problem of air pollution. These regions include, though are not exclusive, to health resorts, an important element of the healthcare industry. Poor air quality is mainly associated with the domestic sector, which is dominated by individual solid fuel and coal boilers. One option for reducing emissions is to use alternative energy sources for heating purposes. Therefore, the paper presents an analysis into the possibility of using low enthalpy (low temperature) geothermal energy in health resort areas. The main purpose of the article is to estimate the potential of soil and water as the lower source for a heat pump. The article presents analyses of geological and hydrogeological conditions based on which the thermal parameters of the rock mass were determined, which were thermal conductivity and unit heat output for 1800 operating hours per year. The calculated values were used to perform a spatial analysis of the data and create maps of the average thermal conductivity for horizontal ground heat exchangers (HGHE) to a depth of 2 and 10 m and vertical ground heat exchangers (VGHE) in depth ranges up to 30, 60, and 90 m. The heating power of the intakes, located in the research area, were estimated using empirical formulas. In addition, a detailed analysis of the physicochemical parameters of groundwater in terms of the requirements indicated by four heat pump manufacturers is presented. The results of the presented research makes it possible to assess the potential of low-temperature geothermal energy and to characterize the suitability of the selected location for the use of HGHE, VGHE, and wells. As a result, the discussed area was found to have a high potential for the use of ground source heat pumps and a moderate potential for the use of low-temperature systems based on groundwater.
Experimental Investigation on Influence of Shed Parameters on Surface Rainwater Characteristics of Large-Diameter Composite Post Insulators under Rain Conditions
Authors: Hao Yanpeng , Liao Yifan , Kuang Zhiqiang , Sun Yijie , Shang Gaofeng , Zhang Weixun , Mao Guiyun , Yang Lin , Zhang Fuzeng , Li Licheng
Published: September 2020

The discharges of water columns and droplets between the sheds make the leakage distance not effectively used, which is one of the main reasons for flashover of composite post insulators under heavy rainfall. To study the influence of shed parameters on surface rainwater characteristics, artificial rain tests were carried out on the large-diameter composite post insulators under the rainfall intensity of 2–15 mm/min. Lwc (the length of water columns at the edge of large sheds), Nwc (the number of water columns at the edge of large sheds), Nwde (the number of water droplets at the edge of large sheds) and Nwds (the number of water droplets in the space between two adjacent large sheds) were proposed as the parameters of surface rainwater characteristics. The influences of large shed spacing, large shed overhang and rod diameter on the parameters of surface rainwater characteristics under different rainfall intensities were analyzed. The experimental results show that, under the same rainfall intensity, with the rise in large shed spacing, large shed overhang or rod diameter, Lwc, Nwc, Nwde and Nwds all increase. Under different rainfall intensities, the trends of the parameters with the change in shed parameters are basically invariant; however, the change ranges of the parameters are different. The increases in the parameters with the rises in shed parameters and rainfall intensity are mainly attributed to the change in the rainfall on the insulator surface. The experimental results can provide references for the quantitative description of surface rainwater characteristics and the design of large-diameter composite post insulators for DC transmission systems.
Speed Fluctuation Suppression Based on an Adaptive Periodic Disturbance Observer for an Inverter Compressor
Authors: Meng Fankun , Li Zhengguo , Sun Xiaoli , Wen Xiaoqin , Negnevitsky Michael , You Linru
Published: September 2020

Repetitive operations have been extensively used in the inverter compressor refrigeration industry. The approximately periodic disturbance caused by repetitive operations must be compensated to realize stable and high-efficiency operation. In this paper, a periodic disturbance observer (PDOB) is proposed to tackle the speed fluctuation of an inverter compressor in the low-frequency range. Periodic disturbance, consisting of a fundamental wave and corresponding harmonics, can thus be estimated and compensated; in addition, sensitivity and complementary sensitivity can reach a compromise through the use of a certain parameter. Aiming at a different operation environment, an adaptive notch filter based on the Steiglitz–McBride method is employed to estimate the fundamental frequency of periodic disturbance. Finally, the feasibility of our approach is verified by MATLAB simulation, and experiments are implemented to illustrate that speed fluctuation can be more effectively attenuated by the proposed method in comparison with general DOB.
“In Situ” Evaluation of Mechanical Wear of Mobile Contacts of Electricity Voltage Regulator
Authors: Steiner Max Gabriel , Spacek Anderson Diogo , Neto João Mota , Moura Pedro Rodrigo Silva , Junior Oswaldo Hideo Ando , Izidoro Cleber Lourenço , Bilessimo Luciano Dagostin , Spacek Jefferson Diogo
Published: September 2020

This in situ study presents an analysis of the wear of mobile contacts of switching in an automatic line voltage regulator, regarding the surface wear of the contacts. It is interesting to analyze the contacts of this equipment due to the friction and wear generated during the contact change, in order to predict and contain mechanical operation failures. The contacts were evaluated for mass loss, profilometry, and analysis in a scanning electron microscope, after remaining in operation in the regulator for about one year and switching the contacts almost 2500 times. This study aims to evaluate the performance of the contacts, in terms of surface wear, correlating the number of switching and the effects generated on the contacts in terms of loss of mass and surface damage. With the results obtained, it is possible to conclude that with each switching maneuver the mobile contact loses about 0.002895% of its initial mass. In addition, there was a change in the topography of the sample, associated with its wear, suggesting that the wear is different along the surface of the regulator contacts studied.
Multiobjective Optimisation of a Marine Dual Fuel Engine Equipped with Exhaust Gas Recirculation and Air Bypass Systems
Authors: Stoumpos Sokratis , Theotokatos Gerasimos
Published: September 2020

Dual fuel engines constitute a viable solution for enhancing the environmental sustainability of the shipping operations. Although these engines comply with the Tier III NOx emissions regulations when operating at the gas mode, additional measures are required to ensure such compliance at the diesel mode. Hence, this study aimed to optimise the settings of a marine four-stroke dual fuel (DF) engine equipped with exhaust gas recirculation (EGR) and air bypass (ABP) systems by employing simulation and optimisation techniques, so that the engine when operating at the diesel mode complies with the ‘Tier III’ requirements. A previous version of the engine thermodynamic model was extended to accommodate the EGR and ABP systems modelling. Subsequently, a combination of optimisation techniques including multiobjective genetic algorithms (MOGA) and design of experiments (DoE) parametric runs was employed to identify both the engine and the EGR/ABP systems settings with the objective to minimise the engine brake specific fuel consumption and reduce the NOx emissions below the Tier III limit. The derived simulation results were employed to analyse the EGR system involved interactions and their effects on the engine performance and emissions trade-offs. A sensitivity analysis was performed to reveal the interactions between considered engine settings and quantify their impact on the engine performance parameters. The derived results indicate that EGR rates up to 35% are required, so that the investigated engine with EGR and ABP systems, when operating at the diesel mode, achieves compliance with the ‘Tier III’ NOx emissions, whereas the associated engine brake specific fuel consumption penalty is up to 8.7%. This study demonstrates that the combination of EGR and ABP systems can constitute a functional solution for achieving compliance with the stringent regulatory requirements and provides a better understating of the underlined phenomena and interactions of the engine subsystems parameters variations for the investigated engine equipped with EGR and ABP systems.
Membrane-Assisted Removal of Hydrogen and Nitrogen from Synthetic Natural Gas for Energy-Efficient Liquefaction
Authors: Qyyum Muhammad Abdul , Chaniago Yus Donald , Ali Wahid , Saulat Hammad , Lee Moonyong
Published: September 2020

Synthetic natural gas (SNG) production from coal is one of the well-matured options to make clean utilization of coal a reality. For the ease of transportation and supply, liquefaction of SNG is highly desirable. In the liquefaction of SNG, efficient removal of low boiling point impurities such as hydrogen (H2) and nitrogen (N2) is highly desirable to lower the power of the liquefaction process. Among several separation processes, membrane-based separation exhibits the potential for the separation of low boiling point impurities at low power consumption as compared to the existing separation processes. In this study, the membrane unit was used to simulate the membrane module by using Aspen HYSYS V10 (Version 10, AspenTech, Bedford, MA, United States). The two-stage and two-step system designs of the N2-selective membrane are utilized for SNG separation. The two-stage membrane process feasibly recovers methane (CH4) at more than 95% (by mol) recovery with a H2 composition of ≤0.05% by mol, but requires a larger membrane area than a two-stage system. While maintaining the minimum internal temperature approach value of 3 °C inside a cryogenic heat exchanger, the optimization of the SNG liquefaction process shows a large reduction in power consumption. Membrane-assisted removal of H2 and N2 for the liquefaction process exhibits the beneficial removal of H2 before liquefaction by achieving low net specific power at 0.4010 kW·h/kg·CH4.
Assessing the Energy Performance of Prefabricated Buildings Considering Different Wall Configurations and the Use of PCMs in Greece
Authors: Tsoka Stella , Theodosiou Theodoros , Papadopoulou Konstantia , Tsikaloudaki Katerina
Published: September 2020

Despite the multiple advantages of prefabricated compared to conventional buildings, such as significant reductions in cost and time, improved quality and accuracy in manufacture, easy dismantling and reuse of components, reduction in environmental degradation, increase of productivity gains, etc., they still share a small part of the European building stock, mainly in the Mediterranean. This paper attempts to highlight the potential of prefabricated buildings to achieve advanced levels of performance, particularly as regards their thermal and energy behavior. More specifically, in this paper the energy needs of a single-family building constructed with prefabricated elements is analyzed, considering different climate contexts. The prefabricated elements comprising the building envelope were developed in order to address specific requirements with respect to their structural, hygrothermal, energy, fire, acoustical, and environmental performance, within the research project SUPRIM (sustainable preconstructed innovative module). The new multifunctional building element, also incorporating phase change materials for increased latent thermal heat storage, has been proven to be beneficial in all the examined climate zones. The results of the relevant studies will highlight the contribution of the new prefabricated element to the sustainability of the overall construction, as well as its advantages when compared with conventional constructions.
Agent-Based Energy Sharing Mechanism Using Deep Deterministic Policy Gradient Algorithm
Authors: Kuang Yi , Wang Xiuli , Zhao Hongyang , Huang Yijun , Chen Xianlong , Wang Xifan
Published: September 2020

Balancing energy generation and consumption is essential for smoothing the power grids. The mismatch between energy supply and demand would not only increase the cost on both sides, but also has a great impact on the stability of the system. This paper proposes a novel energy sharing mechanism (ESM) to facilitate the consumption of local energy. With the help of the ESM, multiple prosumers have an opportunity to share surplus energy with neighboring prosumers. The problem is formulated as a leader–follower framework based on the Stackelberg game theory. To address the aforementioned problems, a deep deterministic policy gradient (DDPG) is applied to solve the Nash equilibrium (NE). The numerical results demonstrate that the proposed method is more stable than the conventional reinforcement learning (RL) algorithm. Moreover, the proposed method can converge to NE and find a relatively good energy sharing (ES) pricing strategy without knowing the specific system information. In short, it is notable that the proposed ESM can be seen as a win–win strategy for both prosumers and the power system.
Real-Time Flow Control of Blade Section Using a Hydraulic Transmission System Based on an H-Inf Controller with LMI Design
Authors: Liu Tingrui , Zhao Kang , Sun Changle , Jia Jiahao , Liu Guifang
Published: September 2020

Vibration and real-time flow control of the 2D blade section of wind turbines with three degrees of freedom (3-DOF), excited by external pitch motion, are investigated based on an H-inf (H∞) controller using linear-matrix-inequality (HIC/LMI) design. The real-time flow control for the purpose of aeroelastic flutter suppression includes not only the driving process of real-time physical equipment, but also the realization of real-time control algorithm in the physical controller. The aeroelastic system combined with pitch motion is controlled by a kind of HIC/LMI algorithm. The real-time external pitch motion is driven by rack-piston cylinder (RPC) using a hydraulic transmission system (HTS). The unsteady aerodynamic loads model is simplified by the HTS system. The HTS is actuated by a proportional-flow valve (PFV) which is controlled by another HIC/LMI algorithm, a novel algorithm for waveform tracking. According to the result of waveform tracking, the input current signal of PFV is realized by the configuration of the controller hardware system and its external circuits. In two types of HIC/LMI algorithms, controller stabilities are affirmed using Lyapunov analyses, and controller values are derived and obtained by using LMI designs. Flutter suppression for divergent and instable displacements is shown, with obvious controlled effects illustrated. An online monitoring experimental platform using hardware-in-the-loop simulation, based on Siemens S7-200 programmable logic controller (PLC) hardware and Kingview detection system, is built to implement pitch motion based on HTS and configure the signal input of PFV in pitch control.
An Approach to Detecting Cyber Attacks against Smart Power Grids Based on the Analysis of Network Traffic Self-Similarity
Authors: Kotenko Igor , Saenko Igor , Lauta Oleg , Kribel Aleksander
Published: September 2020

The paper discusses an approach for detecting cyber attacks against smart power supply networks, based on identifying anomalies in network traffic by assessing its self-similarity property. Methods for identifying long-term dependence in fractal Brownian motion and real network traffic of smart grid systems are considered. It is shown that the traffic of a telecommunication network is a self-similar structure, and its behavior is close to fractal Brownian motion. Fractal analysis and mathematical statistics are used as tools in the development of this approach. The issues of a software implementation of the proposed approach and the formation of a dataset containing network packets of smart grid systems are considered. The experimental results obtained using the generated dataset have demonstrated the existence of self-similarity in the network traffic of smart grid systems and confirmed the fair efficiency of the proposed approach. The proposed approach can be used to quickly detect the presence of anomalies in the traffic with the aim of further using other methods of cyber attack detection.
Development of Interlocking Concrete Blocks with Added Sugarcane Residues
Authors: Ribeiro Bruno , Uchiyama Tadaaki , Tomiyama Jun , Yamamoto Takashi , Yamashiki Yosuke
Published: September 2020

The use of sugarcane residues in mortar and concrete is believed to contribute to a reduction of costs and environmental problems, such as the reduction of mining of natural aggregates and incorrect disposal of the sugarcane residues. Bagasse fiber has a high water retention rate and thus may be considered as a countermeasure for urban heat islands. Because of these properties, bagasse fiber and bagasse sand were added into the preparation of the interlocking concrete blocks. An investigation of the flexural strength and the contribution of the sugarcane residues against an urban heat island was made. The results showed that, by adding 2.0% of bagasse fiber and 5.0% of bagasse sand in concrete, the flexural strength and the water retention content increased in comparison to the control composite. Moreover, the surface temperature and the water evaporation rate of the blocks were smaller in comparison to the control composite.
High Power Ultrasound Treatments of Red Young Wines: Effect on Anthocyanins and Phenolic Stability Indices
Authors: Celotti Emilio , Stante Stefano , Ferraretto Paola , Román Tomás , Nicolini Giorgio , Natolino Andrea
Published: September 2020

Polyphenols, especially anthocyanins, play an important role on red wine sensory qualities and their evolution during storage. High Power Ultrasound (HPU) has been recognized as one of the most promising technologies which can be applied in winemaking processes for several purposes, and it is recently officially approved for crushed grapes treatments. The effect of ultrasound amplitude (41 and 81%) and treatment time (1, 3, and 5 min) has been studied on anthocyanins, flavan-3-ols, tannins, polymerized pigments, HCl index, and the color intensity of two finished red young wines. Anthocyanins and phenols compounds were not degraded with an increase in amplitude and sonication time, and the chromatic properties of the selected wines were preserved. Amplitude and ultrasound time were also evaluated considering their effect on evolution of anthocyanin content and phenolic stability indices during the first thirty days of storage. The higher level of amplitude (81%) induced a higher percentage decrease in tannins, 15% and 40% after 15 and 30 days of storage, respectively, compared to untreated wine which did not show a significant change during storage. HPU shows a possible chemical effect on the evolution of some analytical indices during bottling maturation, but their effectiveness could be strictly linked with the initial phenolic profile and ratios between polyphenol classes.
Antique Traditional Practice: Phenolic Profile of Virgin Olive Oil Obtained from Fruits Stored in Seawater
Authors: Torić Jelena , Barbarić Monika , Uršić Stanko , Jakobušić Brala Cvijeta , Karković Marković Ana , Zebić Avdičević Maja , Benčić Đani
Published: September 2020

Virgin olive oil (VOO) is a functional food specific to the Mediterranean diet and related to human health, especially as a protector of cardiovascular health, in the prevention of several types of cancers, and in modification of immune and inflammatory response. Phenolic compounds have central importance for these extraordinary health benefits. In the production of high-quality olive oils, it is very important to process freshly picked olives and avoid any storage of fruits. However, in Croatia there is a very traditional and environmentally friendly method of olive oil production, where olive fruits are stored in seawater for some time prior to processing. This practice is also notable nowadays since there are people who prefer the characteristic flavor of the “seawater olive oil”, although some people argue against its quality and biomedical relevance. In this study, the phenolic contents of VOO prepared from the immediately processed fresh olives and olives processed after storage in seawater were compared with the use of high-performance liquid chromatography-mass spectrometry (HPLC-MS) and spectrophotometric analysis. The results suggest that “seawater olive oil” should be considered as a safe food of biomedical relevance, as it still contains a significant proportion of important phenolics like hydroxytyrosol, tyrosol and oleacein (e.g., 63.2% of total phenols in comparison to VOO).
Exploring New and Modified Rejection-Type Thresholds Using Cricket Snack Crackers
Authors: Ardoin Ryan , Romero Ross , Marx Brian , Prinyawiwatkul Witoon
Published: September 2020

Recently, sensory threshold concepts have been expanded to include affective perceptions of foods and beverages, especially measures of product rejection; however, each threshold interpretation depends largely on the methodology employed. By substituting cricket powder for whole-wheat flour in snack crackers (0%, 5%, 10%, 15%, and 20%), we proposed modifications to two existing threshold methodologies: a modified consumer rejection threshold (M-CRT) using a 2-alternative choice (2-AC) preference test with “no preference” option; and a modified hedonic rejection threshold (M-HRT) based on less-than-neutral hedonic scores according to a one-sample t-test. We also proposed two new concepts: a rejection tolerance threshold (RTT) and an associated rejection range (RR), based on a binomial acceptability question and a probit regression model. These new methods provide more realistic interpretations of rejection-type thresholds based on user-defined allowable rejection levels, or “rejection tolerance” (for RTT), and a model-derived stimulus range (RR) to capture the rejection level of interest while providing flexibility for product formulation. All thresholds were investigated separately for color, flavor, texture and overall perception, elucidating differential sensorial effects of our novel ingredient on the food matrix. We suggest that conducting all demonstrated techniques in a single testing session gives a more expansive view of rejection thresholds while requiring minimal additional resources.
Application of 1H Nuclear Magnetic Resonance Spectroscopy as Spirit Drinks Screener for Quality and Authenticity Control
Authors: Teipel Jan C. , Hausler Thomas , Sommerfeld Katharina , Scharinger Andreas , Walch Stephan G. , Lachenmeier Dirk W. , Kuballa Thomas
Published: September 2020

Due to legal regulations, the rise of globalised (online) commerce and the need for public health protection, the analysis of spirit drinks (alcoholic beverages >15% vol) is a task with growing importance for governmental and commercial laboratories. In this article a newly developed method using nuclear magnetic resonance (NMR) spectroscopy for the simultaneous determination of 15 substances relevant to assessing the quality and authenticity of spirit drinks is described. The new method starts with a simple and rapid sample preparation and does not need an internal standard. For each sample, a group of 1H-NMR spectra is recorded, among them a two-dimensional spectrum for analyte identification and one-dimensional spectra with suppression of solvent signals for quantification. Using the Pulse Length Based Concentration Determination (PULCON) method, concentrations are calculated from curve fits of the characteristic signals for each analyte. The optimisation of the spectra, their evaluation and the transfer of the results are done fully automatically. Glucose, fructose, sucrose, acetic acid, citric acid, formic acid, ethyl acetate, ethyl lactate, acetaldehyde, methanol, n-propanol, isobutanol, isopentanol, 2-phenylethanol and 5-(hydroxymethyl)furfural (HMF) can be quantified with an overall accuracy better than 8%. This new NMR-based targeted quantification method enables the simultaneous and efficient quantification of relevant spirit drinks ingredients in their typical concentration ranges in one process with good accuracy. It has proven to be a reliable method for all kinds of spirit drinks in routine food control.
Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry
Authors: Martin Maria E , Grao-Cruces Elena , Millan-Linares Maria C , Montserrat-de la Paz Sergio
Published: September 2020

Wine production is an ancient human activity that generates several by-products, which include some constituents known for their potential in health care and for their role in the food or cosmetic industries. Any variety of grape (Vitis vinifera L.) contains nutrients and bioactive compounds available from their juice or solid parts. Grape seed extract has demonstrated many activities in disease prevention, such as antioxidant effects, which make it a potential source of nutraceuticals. Grape seed is a remarkable winery industry by-product due to the bioactivity of its constituents. Methods for recovery of oil from grape seeds have evolved to improve both the quantity and quality of the yield. Both the lipophilic and hydrophilic chemicals present in the oil of V. vinifera L. make this wine by-product a source of natural nutraceuticals. Food and non-food industries are becoming novel targets of oil obtained from grape seeds given its various properties. This review focuses on the advantages of grape seed oil intake in our diet regarding its chemical composition in industries not related to wine production and the economic and environmental impact of oil production.
Evolution of Cooperation in Social Dilemmas with Assortative Interactions
Authors: Iyer Swami , Killingback Timothy
Published: September 2020

Cooperation in social dilemmas plays a pivotal role in the formation of systems at all levels of complexity, from replicating molecules to multi-cellular organisms to human and animal societies. In spite of its ubiquity, the origin and stability of cooperation pose an evolutionary conundrum, since cooperation, though beneficial to others, is costly to the individual cooperator. Thus natural selection would be expected to favor selfish behavior in which individuals reap the benefits of cooperation without bearing the costs of cooperating themselves. Many proximate mechanisms have been proposed to account for the origin and maintenance of cooperation, including kin selection, direct reciprocity, indirect reciprocity, and evolution in structured populations. Despite the apparent diversity of these approaches they all share a unified underlying logic: namely, each mechanism results in assortative interactions in which individuals using the same strategy interact with a higher probability than they would at random. Here we study the evolution of cooperation in both discrete strategy and continuous strategy social dilemmas with assortative interactions. For the sake of tractability, assortativity is modeled by an individual interacting with another of the same type with probability r and interacting with a random individual in the population with probability 1−r, where r is a parameter that characterizes the degree of assortativity in the system. For discrete strategy social dilemmas we use both a generalization of replicator dynamics and individual-based simulations to elucidate the donation, snowdrift, and sculling games with assortative interactions, and determine the analogs of Hamilton’s rule, which govern the evolution of cooperation in these games. For continuous strategy social dilemmas we employ both a generalization of deterministic adaptive dynamics and individual-based simulations to study the donation, snowdrift, and tragedy of the commons games, and determine the effect of assortativity on the emergence and stability of cooperation.
Telemedicine in Times of the Pandemic Produced by COVID-19: Implementation of a Teleconsultation Protocol in a Hospital Emergency Department
Authors: Lopez-Villegas Antonio , Maroto-Martin Salvador , Baena-Lopez Miguel Angel , Garzon-Miralles Antonio , Bautista-Mesa Rafael Jesús , Peiro Salvador , Leal-Costa Cesar
Published: September 2020

Since the first case of COVID-19 was reported in Spain, almost 22% of healthcare professionals have been infected. Among the main causes are exposure during the care of suspected patients and asymptomatic patients, which caused a greater lack of protection in some cases, and to the global shortage of personal protective equipment due to the strong demand for it. The main objective of this study was to evaluate the effectiveness of a teleconsultation protocol with patients who had respiratory symptoms in the reduction of the consumption of personal protective equipment (PPE) in a hospital emergency service (HES) during the COVID-19 pandemic. This is a descriptive and retrospective study that analyzes the implementation of a teleconsultation protocol with patients with respiratory problems treated in the HES at the Hospital de Poniente (Almeria), between 18 March and 30 April 2020. In the selected study period, 5353 patients were treated in the HES of the Hospital de Poniente; of these, 15.43% showed respiratory symptoms and were referred to the Respiratory Circuit, of which 42.2% did so via teleconsultation. Sixty-six cases of COVID-19 were diagnosed, 57.6% were male, and the median age was 71 years old. The main disease related was pneumonia (89.4%), symptoms more frequent were cough (77.3%), fever (77.3%), and dyspnea (60.6%). Lastly, 56.1% of the patients that attended had one or more comorbidities, high blood pressure (53%), and diabetes (36.4%), which became the main risk factors. The results showed that the implementation of teleconsultation in the HES reduced the possibility of infection and allowed for a more efficient consumption of personal protective equipment.