bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical value of the Takata-Ara fuchsin-sublimate reaction in the study of cerebrospinal fluid
Authors: Zimin A. N.
Published: March 2022

It is known how important, sometimes decisive, data from studies of cerebrospinal fluid are in the recognition of neuro-mental diseases. Hence the interest in all kinds of research in the field of biochemical and other studies of cerebrospinal fluid is understandable. During the most recent time, a number of new reactions have been proposed and some of them have proved to be very valuable and have acquired the full right of citizenship.
Experience of tuberculous skin lesions treated with the metal antagen Negreu Boquef
Authors: Olesov I. N.
Published: March 2022

In dermatology, the group of tuberculous skin diseases is extensive and clinically extremely diverse. It is now well known that lupus vulgaris, erythema indur. Bazin, lichen scrophulosorum, tuberculosis verrucosa cutis, scrophuloderma, lupus miliaris disseminatus are only morphological varieties of the same tuberculous process in the skin. Koch's work showed that not only bacteria can be the cause of the disease, but also their waste products toxins.
New devices for blood transfusion, local anesthesia and other medical and technical purposes
Authors: Tsimkhes I. L. , Palkin-Miloslavsky I. T.
Published: March 2022

Every year there is a growing interest in the issue of blood transfusion and local anesthesia. Thanks to the colossal advances achieved by medicine in these areas, we are able to use these methods in surgical practice. However, a big hindrance to the widespread use of these methods is still the complexity of techniques that require special knowledge. The equipment currently used for blood transfusion and local anesthesia does not fully meet the required tasks, complicates the technique of producing blood transfusion and local anesthesia, and also lengthens the production time.
Echinococcus horseshoe kidney
Authors: Bazhenov P. S.
Published: March 2022

Echinococcus kidney is a rare disease. Keropian, in his monograph on echinococcus of the kidney, could only give 86 cases of echinococcus of the kidney and perirenal tissue, which he found in Russian literature 46 years before the end of 1928.
About rhinoscleroma
Authors: Borshchev K. G.
Published: March 2022

Since the Viennese dermatologist Gebra (in 1870) first described rhinoscleroma, the issue of this disease has been highlighted many times in the literature. However, until now, rhinoscleroma has not lost interest, since this disease is relatively rare, very insufficiently studied and, at the same time, characterized by severe and sometimes sad consequences for the patient. The very important issue of finding focal sites of scleroma has not yet been studied.
Symptoms of dullness and retraction of the eye in pulmonary tuberculosis
Authors: Tamarin I. L.
Published: March 2022

Old authors (Yanovskiy, Kornet) noted vivid, phosphoric, shiny eyes as a symptom of pulmonary tuberculosis. Often these lively, glowing and even sometimes sparkling eyes are replaced by a special shade, as if a slight veil, with dullness of the sclera and cornea, with a simultaneous retraction of the eyeball (enophthalmus).
On the issue of extensive resections of the small intestine
Authors: Ostrovsky M. I.
Published: March 2022

Having two cases of extensive resection of the small intestine, we consider it necessary to highlight these cases on the pages of the press.
Cases of pericardial pericardial injury without heart damage
Authors: Bagrov Yu. B.
Published: March 2022

June 14, 1933 at the surgeon. the department was delivered to the b-th Yak-va, 32 y., who received a stab wound on the left side of the chest of Finnish knives an hour ago (source number 7489).
Puerperal inflammation of the urachus'a cyst
Authors: Lieberberg R. M.
Published: March 2022

2. IX, 1931, a 25-year-old villager-collective farmer M. Ch., 25 years old, was brought to the isolation ward of the hospital from a distant area with a doctor's press that a patient with parametritis and an umbilical fistula was being sent. The patient gave birth 2 times, the last time a year ago. Since then he has not menstruated. A very short time after giving birth (does not remember exactly), pus began to come out through her navel. There were no abortions or bleeding. On the part of the stool and urination, there are no deviations from the norm, at times there is only frequent urination.
Gilyarovsky, speaking of "the form, content and flow in psychosis" ("Council, not vropat., Psychiatr. And psychogig." T. I. issue 8, 1932)
Authors: Galant Yves.
Published: March 2022

Gilyarovsky, speaking about the "form, content and course in psychosis" ("Council, not vropat., Psychiatr. And psychogyny." in psychosis and to a certain extent determines the form and content of psychosis.
On the hysterical development of personality. Molokhov. Council, neuropath., Psychiatrist, and psychogig. T. I, issue 12.1932
Authors: Galant Yves.
Published: March 2022

Molokhov (On the hysterical development of personality. Council, neuropath., Psychiatrist, and psychogig. Vol. I, issue 12.1932) speaks of psychopathic developments, emphasizing, in contrast to the old views on psypathy, the primacy of external, exogenous moments in the development of psychopathy ... There is no disposition that fatally leads to hysteria.
Steblov gives a "Criticism of the classifications of epileptic forms" (Council, neuropath., Psychiatrist, and psychogig. Vol. II, issue 1)
Authors: Galant Yves.
Published: March 2022

Steblov gives "Criticism of the classifications of epileptic forms" (Council, neuropath., Psychiatrist, and psychogig. Vol. II, issue 1). Modern classifications cannot satisfy us, but with the present state of our knowledge there is no way to give a new scientific classification of epileptic forms.
Franke (Franke, Ueber Pellagra in Irrenanstalten. Psycbiatrisch-Neurol Woehenschrift, no. 38, 1933)
Authors: Galant Yves.
Published: March 2022

Franke (Franke, Ueber Pellagra in Irrenanstalten. Psycbiatrisch-Neurol Woehenschrift, no. 38, 1933) defines pellagra as a predominantly psychiatric-neurological disease occurring in Germany chap. arr. in psychiatric hospitals.
Magenau (Magellan. Eigenblutbehandlung der Schizophrenia. Psych.-Nourol. W. No. 38, 1933)
Authors: Galant Yves.
Published: March 2022

Magenau (Magellan. Eigenblutbehandlung der Schizophrenia. Psych.-Nourol. W. No. 38, 1933) indicates the unsafe use of autohemotherapy, which is now in great fashion. There are cases with formidable anaphylactic phenomena.
About operations for inguinal hernia. Prof. Dguneg (Zotralblatt f. Chir. 1933, no. 36)
Authors: Tsimkhes I.
Published: March 2022

About operations for inguinal hernia. Prof. Duner (Zotralblatt f. Chir. 1933, No. 36) will join the opinion that it is not necessary to suture the muscles with the pupar ligament when restoring the inguinal canal, as this leads to muscle atrophy and scarring.
Paravertebral injections for pacreatitis. D-r Hans L. Popper (Zntrlbl f. Chir. 1933, no. 35)
Authors: Tsimkhes I.
Published: March 2022

Paravertebral injections for pacreatitis. D-r Hans L. Popper (Zntrlbl f. Chir. 1933, No. 35) suggests for diagnostic and sometimes therapeutic purposes to produce paravertebral injections of novocaine (D 8-10 left).
"Quinine-pituitary course" in the therapy of febrile abortions. Habbe Zbl. F. Gyn., 1933, No. 2)
Authors: Manenkov P.
Published: March 2022

"Quinine-pituitary course" in the therapy of febrile abortions. Habbe Zbl. F. Gyn., 1933, No. 2) has successfully applied in cases of febrile abortion a medical expectant method of treatment, published in 1932.
Impressions of the V All-Ukrainian Congress of Surgeons
Authors: Ayber S. M.
Published: March 2022

From the very first moments of the work of the congress, clear organization, a well-thought-out program of meetings and the filled time of the day of its members spent with great satisfaction were visible. The opening of the congress, as well as its further work, took place in front of the D-me of the Red Army, who amazed with his boat with its awe-inspiring simplicity, strict style and vastness of light rooms. Prof. Shamov (Kharkov), from the curve the congress is the result of the collective creativity of surgeons, celebrated it as a holiday of scientific research thought in our Union, while abroad the terrible depression "Hammer and Sickle" is self-sufficient - the Kharkov plant sent its working delegates to the congress , demonstrating the close link between science and labor.
Comparing corporate governance practices of state-owned enterprises (SOEs) in South Africa and Singapore
Authors: Adebayo Adeyemi , Ackers Barry
Published: March 2022

Research aims: This paper undertakes a cross-country comparative analysis of corporate governance of state-owned enterprises (SOEs) in South Africa and Singapore, two countries using two different models for organising SOEs, with specific reference to agreement with the themes identified in the World Bank’s Framework for good Corporate Governance practices for SOEs. The aim of this paper is to identify differences and similarities in practice and to document how the states have fared using different models.Design/Methodology/Approach: The paper deploys a pragmatic mixed methods approach conducted in two phases, to understand the practices utilised by South African and Singaporean SOEs. The data emerging from these two phases, were compared to the Framework for good Corporate Governance practices for SOEs issued by the World Bank.Research findings:  Findings suggest although South African SOEs have good corporate governance practices in place, Singaporean SOEs are better organised and governed compared with South African SOEsTheoretical contribution/Originality: This paper contributes to the scholarly discourse on SOEs in by expanding the discourse on public sector entrepreneurship and opening up new debates and research areas corporate governance of SOEs.
Effect of hormonal supplementation on pain tolerance in women– A comparative study
Authors: Reddy V Bhavya , Sahithi M , Padmini O
Published: March 2022

Gonadal hormones (oestrogen and progesterone) influences pain sensitivity, the former strongly influences nociceptive actions, whereas the latter prevents neuropathic pain. However, there is only little evidence on direct effect of hormonal based drugs on experimental pain response. Therefore the aim of the present study is to the difference in response to pain stimulus in terms of - pain threshold, pain tolerance, pain intensity, pain unpleasantness between women on OCP pills, normal menstruating women and age matched men using cold pressor test.

Total of 50 females (20-35 years age group) on COCP pills, 50 controls (normal menstruating women of 20-35 years age group) and 50 healthy males (20-35 years age group) were enrolled in the study as per the eligibility criteria. Cold pressor test was used as a stimulus source. The participants were instructed to hold their least dominant hand in the water bath (maintained between between 0°C and 2°C) as long as possible and were requested to inform the first sensation of pain which denoted the participants’ pain threshold. Time from pain threshold to the point where participants could no longer cope with pain and indicate stop, was recorded as pain tolerance. At this point participants were directed to note pain intensity and unpleasantness on the visual analogue scale.Statistical analysis of data was done using standard SPSS software. Data was represented as mean standard deviation. Chi-square test was done and p values <0.05 were considered significant.

Average pain tolerance was significantly (p<0.00) higher in women on COCP (combined oral contraceptive pill) therapy compared to naturally menstruating women. But men and women on COCP pill therapy do not differ significantly in average pain tolerance. The average pain threshold did not differ significantly between any age groups. The average pain unpleasantness was less in females taking hormonal pills compared to men and naturally menstruating women establishing the role of increased levels of sex hormones in reducing the discomfort and unpleasantness. There was no significant difference in average pain intensity between men and normal women but it differed significantly between normal women and women on COCP therapy.

The use of COCP affects the pain reporting of subjects.
Reference intervals and gender variation in establishing blood parameters in dental institution: A retrospective study
Authors: Adhane Yogita Bhaginath , Sardar Manisha Ahire , Chettiankandy Tabita Joy , Sachdev Sanpreet Singh , Tupkari Jagdish Vishnu
Published: March 2022

Complete blood count (CBC) has been extensively used by general physicians to assess the status of sick and healthy people. The aim of the present study was to appraise the hematological changes in different blood parameters amongst males and females and also to set a reference range for general population.

The study was conducted on 361 patients of age 18-50 years comprising of 163 males (45.2%) and 198 females (54.8%).20 µl sample of capillary blood was obtained through finger prick and subjected to complete blood count, including a white blood cell (WBC) differential and a reticulocyte count, by means of a fully automatic blood cell counter. The findings were tabulated and subjected to statistical analysis.

The mean values of the RBC, Hb, HCT, MCV, MCH between males and females showed statistically highly significant reduction with p < 0.001, while MCHC was significantly reduced with p < 0.05 in females compared to males (). Haematological parameters such as PLT, PCT were slightly higher in females compared to males showing statistically significant results with p < 0.05.

Blood parameters aid in diagnosis of various disorders and also serve to guide decision making for clinicians. Therefore, periodically establishing reference intervals is crucial for better correlation with health and disease conditions. Our findings would serve to update present available data pertaining to blood parameters, their reference range and gender variation on a regional level.
The morphometric analysis of calcaneus and its articular facets
Authors: Mamidi Anuradha , Jyotsna G
Published: March 2022

Calcaneus being the key bone of the longitudinal arch forms the posterior pillar. It is responsible for receiving the body weight and transmitting it to the plantar arch below.

The aim of the present study is to see the variations in articular facets and dimensions of calcaneus. Ninety-eight dry calcaneus were procured from department of Anatomy, Mediciti Institute of Medical Sciences, Hyderabad. All the bones were of unknown gender that are housed in the collection at department of Anatomy grossly normal without any physical damage.

Among the ninety-eight dry calcaneus, type-B articular facets were seen mostly. Morphometric measurements of calcaneus were similar to that of other studies. Mild variations that were observed might be due to racial or different points taken as reference for measurements.

Analysis of morphometric parameters plays key role in reconstruction surgeries and foot rehabilitation procedures.
Comparison of autonomic functions in moderate and heavy smokers using heart rate variability
Authors: Anitha K S  , Sanjaya G  , Reddy Jaya Simha , Kumar T Kiran , Taklikar Raju H , Gitte Rashmi Narayanrao
Published: March 2022

Previous studies using heart rate variability (HRV) have confirmed decreased HRV in cigarette smokers compared with non smokers. However only few studies have been done considering the effect of smoking on HRV in moderate and severe smokers assessed by pack years. Objective: The main objective of this study was to compare the autonomic functions in male moderate and heavy cigarette smokers.

The present was conducted in our department of Physiology. Permission to conduct the study was obtained from Institutional research ethical committee. This study was conducted among male cigarette smokers with age between 20 to 50 years who were apparently healthy. The study group subjects were divided into moderate and heavy smokers considering both the amount and duration of smoking calculated by pack years. HRV data was recorded, statistical analysis was done by independent sample t test to compare between the groups. A p value of <0.05 was considered as statistically significant whereas a p value <0.001 was considered as highly significant.

The HRV parameters namely Low frequency (LF) component, LF power expressed in normalized unit (LFnu) and LF-HF ratio were significantly higher in heavy smokers compared to moderate smokers. Total power, high frequency (HF) component and HF power expressed in normalized unit (HFnu) were found significantly less in heavy smokers compared to moderate smokers.

Autonomic imbalance characterized by increased sympathetic function with associated decrease in the cardiac vagal modulation was seen in heavy smokers compared to moderate smokers.
Variations in nutrient foramen in the long bones of lower limb
Authors: Roy Rajarshi , Aggarwal Prerana , Medda Shyamalendu
Published: March 2022

Morphology and morphometry of nutrient foramen of bones vary from country to country and from place to place.

Objective was to study the number, position, location, directions, distance of nutrient foramen from the proximal end of femur, tibia and fibula in eastern Indian region.

In a descriptive study, 393 bilateral lower limb long bones (138 femur, 132 tibia & 123 fibulae) were studied.

Total nutrient foramen calculated; 178 in femur, 137 in tibia, 121 in fibula. Most had single foramen; femur (66%), tibia (96%) and fibula (94%). Number of foramina ranged from 0-3 in femur, 1-2 in tibia and 0-2 in fibula. Foramina were present mainly on the posterior surface of the bones [linea aspera in femur (96), below soleal line and lateral to the vertical line in tibia (90) and peroneal crest in fibula (74)]. The mean length, mean distance of nutrient foramen from the proximal end of the bones measured. Most foramina found on the middle third, with foraminal index ranging from 33% to 66%; though on tibia it’s not a common finding. The 't' test value of foraminal index was significant for tibia. Mean foraminal index was measured for femur 42.28%, tibia 35.91%, fibula 41.54%.

The knowledge of anatomical variations of nutrient foramen is very important as preservation of vascularization of long bones is essential in fracture repair, tumor resection, bone grafting.
Morphometric analysis of infraorbital foramen in human dry skull of south Indian population and its clinical implications
Authors: Akshaya S  , KR Dakshayani
Published: March 2022

Infraorbital foramen,an important anatomical landmark in anaesthetic and surgical interventions of the maxillary region, transmits the infra orbital vessels and nerve. Infraorbital nerve block is commonly used in regional anaesthesia for the midface and paranasal surgeries. The purpose of our study to obtain detailed knowledge of the anatomical location and variations of IOF which is imminent for successful regional anaesthesia and endoscopic surgeries of the maxillary region.

The study was conducted on 50 Human skull bones of unknown gender from the Department of Anatomy, Mysore Medical College and Research Institute, Mysore. Both side of skulls were visually observed for shape, direction of the infraorbital foramen and presence of accessory infraorbital foramina. 1. Sagittal Distance between the infraorbital margin to upper margin of infraorbital foramen were measured. 2. Transverse diameter from lateral margin of pyriform aperture to medial margin of IOF were measured. 3. Oblique distance from anterior nasal spine to inferior margin of IOF, were measured. 4. Vertical and transverse diameter of the IOF were measured.

50 skulls (100 sides – both right and left) were studied.

Most commonly observed shape of IOF is semilunar 36% on right side, 40% on left side, transversely oval 20% on right side, 28% on left side, vertically oval 18% on right side, 12% on left side, circular 18% on right side, 8% on left side, triangular 8% on right side 12% on left side. Direction of IOF is 88% medially downwards, 12% downwards.

The mean distance between IOM and IOF is 6.58±0.28 mm on the right side, 6.78 +0.233 mm on the left side. The mean distance between pyriform aperture to of IOF 16.88+3.7mm on the right side 16.46 +2.7 on the left side. The mean distance between ANS to inferior margin IOF on the 34.77+0.55 mm on right side 34.22+0.3 mm on the left side.

Mean vertical diameter of IOF 3.76 mm on right side & 3.94 mm on left side. Mean transverse diameter of IOF 4.18 mm on right side & 4.32+15 mm on left side.

Accessory IOF were present in 6% of skulls bilaterally.

Our study results will be of immense help to the surgeons and anaesthetists, handling this region for operative procedures.
Saliva: A potential specimen for COVID-19 testing
Authors: Choudhari Omkar , Devi Anita , Lal Sandhya , Gangopadhyay Sukanya , Kaushik Nalini , Kaur Charanjeet
Published: March 2022

COVID-19 presence worldwide has brought substantial changes in our thinking process. The conventional biological specimen in disease due to viral aetiology ranges from blood to cerebrospinal fluid, Broncho-alveolar lavage. Through, established means of specimen have high sensitivity, other options like using Saliva specimen for testing in a developing country like India may be cost effective. The COVID-19 pandemic is still an evolving condition and best way to mitigate the infection is to increase in testing per day with isolation of the diseased individuals. Hence, Saliva could serve as a potential specimen for COVID-19 testing moreover available literature from other countries is offering promising results.
Effect of soft drinks on bone
Authors: Dhonde Sushama , Hurria Naman , Jagtap P E , Belwalkar G J , Nagane N S , Bhandare V S , Surayawanshi Kiran , Mane Vinayak , Nunes Neil
Published: March 2022

Adolescence age group has significant impact of advertizing industry for use of soft drink and junk food. Present study is aimed to find out the alteration in the bone markers in medical and dental students, who regularly consume soft drinks.

Students from our institute were divided (n = 200) in two groups. Group A – Students who consume 200 ml or less than 200 ml of soft drink in a week. Group B -Students consuming more than 200 ml of either ‘regular’ soft drink (B1) or ‘diet’ soft drink (B2) per day

There is a significant decrease in the levels of bone density, calcium, phosphorous, vitamin D and increase in the activity of alkaline phosphatase in Group B2 than group A as well as B1.

Diet soft drinks are consumed instead of regular soft drinks, the decrease in the pH due to phosphoric acid and aspartame; may lead to bone demineralization resulting into decreased bone density. Inhibition of 1alpha hydroxylase may get inhibited due to acid pH caused by phosphoric acid from soft drinks. These changes may lead to develop tendency of bone fractures in the future life.
A study of religious beliefs affecting organ donation & influence of educational intervention in western Maharashtra
Authors: Sayyed Anjum A K , Pratinidhi Shilpa A , D'Souza Derek S J , Dhanmane Siddheshwar T
Published: March 2022

In India, many lives that could easily be saved are lost due to a paucity of donated organs. This trend could easily be reversed by educating the general public. Religious beliefs and religious leaders play an important role in the society. With a concept to educate the religious leaders, to strengthen the message of increased organ donation, a study was conceptualized to test the efficacy of such an intervention.

To study religious beliefs and organ donation among the heterogenous population of Maval Taluka.

A cross-sectional study carried out in the Department of Biochemistry, MIMER Medical College, Talegaon Dabhade, Pune.

An educational interventional study was carried out on four basic major religious groups namely Hindu, Muslim, Sikh and Christian. Data was collected from 328 participants by visiting respective religious places. A ten-item self-structured validated questionnaire was designed to assess the knowledge and beliefs regarding organ donation. Pre-test was carried out to assess the basic knowledge on organ donation. Educational intervention regarding the benefits of organ-donation was done, followed by a post-test.

The data was statistically analysed by ANOVA in SPSS software.

The overall awareness on organ donation was increased by 22% after the planned educational intervention.

: These results of the study showed a high degree of acceptance amongst all the groups & willingness for organ donation. Hence, such awareness programmes should be conducted at regular intervals on a large scale so that the problem of shortage of donated organs can be minimized.
Sustainable development through non-conventional energy resources possibility in India
Authors: Ravichandran S , Himanshi  , Madhumitha Sri R M
Published: March 2022

Energy is the major mover of sustainable and economic development. Energy is the key input to drive and improve the life cycle. Primarily it is the gift of the nature to the mankind in various forms. The consumption of energy is directly proportional to the progress of mankind. There is a very high demand for energy, which is currently satisfied mainly by coal, oil and petroleum which are from being a non – renewable and therefore non– permanent solution to the energy crisis. Thus, it is essential to tackle the energy crisis through efficient utilization of abundant renewable energy resources. Renewable energy sources have the potential to provide solutions to the long-standing energy problems being faced by human society. The renewable energy sources like wind energy, solar energy, biomass energy and tidal energy can be used to overcome energy shortage in India. To meet the energy requirement for such a fast growing economy, India will require more supply of energy than the total energy consumed today. The renewable energy is one of the options to meet this requirement. Today, renewable energy account for 33% of India’s primary energy consumptions. India is increasingly adopting responsible renewable energy techniques and taking positive steps towards ensuring a more sustainable future. This paper describes in brief the potentials of renewable energy options in India.
Status of vitamin D in polycystic ovary syndrome: A case control study
Authors: Purohit Ankur , Soni Yogita
Published: March 2022

Vitamin D deficiency has been observed in many cases of Polycystic Ovary Syndrome (PCOS) and many possible links have been discovered regarding its role in the progression of pathophysiology. The aim of this study was to access and compare the level of vitamin D in PCOS patients and healthy women.

This was a case control study. 150 patients of PCOS and 150 age matched healthy controls were enrolled in this study. Serum level of Vitamin D was estimated by immunoassay method by using ELISA technique. The data were compared using independent t-test and chi square test wherever applicable.

The total serum vitamin D level was found significantly (p<0.0001) low in PCOS patients (21.91 ± 8.49 ng/ml) compared to healthy controls (34.12 ± 7.41 ng/ml).

Hypovitaminosis D observed in PCOS cases indicated the possible involvement of vitamin D in the pathophysiological changes of the disease.
D – Dimer, ferritin, lactate dehydrogenase, C – reactive protein, prothrombin time and activated partial thromboplastin time are the significant indicators of suspected Covid – 19 patients
Authors: Shaikh Mahmood , Jafri Syed Ateeq Ahmed , Nasreen Zaheda , Chandan Dussa Hema
Published: March 2022

Covid ‘19 is a pandemic disease, spread all over the world. Covid ‘19 was first detected in Wuhan, China and it was first reported to the WHO country office on 31st December 2019. Covid ‘19 was spread through Corona Virus, this virus initially infected the respiratory tract than to lungs. In the beginning, Covid ‘19 was suspected to spread only with community transformation, later it was assumed that it is an airborne, waterborne, and community transformation disease. Recent clinical research reveals that Corona virus causing mutations and point mutations, still cause is unknown. Covid ‘19 is unstable in the living body, once coronavirus is found positive to a person involving in multiple complications in the body such as cardiovascular dysfunction, renal dysfunction, and other complications in the body. Different Hospitals have shown that when a person was infected with Covid ‘19 that person was severe for breathing problem and collapsing with unknown cause. The affected person's life span was only 48 to 72 hours. The researcher scientists, clinicians are day-night trying to take any suitable solution to control and cure Covid ‘19. Covid ‘19 patients are found changes in their routine life. There is a change in their metabolic functions. There is a change in their physics and also in their Biochemical and Molecular parameters. Mostly their Protein synthesis and coagulation profiles are involved in Covid ’19. The present study is aimed to investigate the value of D- Dimer, ferritin, lactate dehydrogenase, C – Reactive Protein, Prothrombin Time, activate partial prothrombin time are the significant indicators of suspected COVID ’19 - Patients.
A brief review on efficacy and safety of brivaracetam in the management of partial onset epilepsy
Authors: Vithoba Panchal Gajanan , Nath Mishra Vijay
Published: March 2022

Brivaracetam, a propyl analog of levetiracetam is a new Antiepileptic Drug (AED), and the first selective ligand that binds to synaptic vesicle protein 2A (SV2A). Brivaracetam has 15–30 times greater affinity for SV2A and faster Blood-Brain Barrier permeability. This review examines the use of brivaracetam as add-on (50–200 mg/day) therapy for partial onset epilepsy with particular emphasis on its early onset of action, long-term efficacy, and safety profile. When initiating treatment with brivaracetam, gradual dose escalation is not required, and right therapeutic dose can be administered on first day itself. In pooled analysis of three phase-3 studies, early ≥50% responder rate (on day 1) was found across all brivaracetam treatment groups i.e. 15.5%, 18.1%, 19.4%, for 50, 100, 200 mg/day, respectively. In 11-year, follow-up trial, brivaracetam showed 50% responder rate as 55.6% which increased by exposure through 3 years and remained consistent through 9 years. Seizure freedom rates were 30.3% at 6 months and 20.3% at 12 months. Another long-term follow-up study involving 2,051 patients also reported increased ≥50% seizure reduction with brivaracetam in partial onset seizure from baseline over 5 years, 71.0% (at 58–60 months). In addition, brivaracetam demonstrated a favorable safety profile with minimal drug-drug interactions, lesser incidence of behavioral and psychiatric adverse effects. Brivaracetam also demonstrates improvement in cognitive profile and executive functions with reduced anxiety and improvement in quality of life in patient with epilepsy.
Thrombolysis with novel tenecteplase in acute ischemic stroke: A prospective observational study from a rural tertiary care center in South India
Authors: N.C Krishnadas , Fazal Ghafoor P.A. , Rafeeque Mohammed , V Rajmohan , Subir Ahamed
Published: March 2022

Tenecteplase is an approved engineered recombinant tissue plasminogen activator for treatment of acute ischemic stroke with molecular and practical advantages. It could be quintessential in this era of endovascular care provided that more studies come out, especially from resource poor settings.

To observe the clinico-epidemiological profile and to assess the outcome of acute ischemic stroke patients treated with tenecteplase.

A prospective observational study of stroke patients treated with tenecteplase. On admission clinical characteristics, temporal, epidemiological, imaging parameters, outcome measures including baseline NIHSS, NIHSS at 1 hour, 24 hours, at discharge, and modified Rankin Scores (mRS) at 0, 1 and 3 months were recorded in a structured proforma.

Out of the 19 patients thrombolysed with tenecteplase 68.4% were males. Mean age of the study population was 61.3 years. Hypertension (57.9%), diabetes mellitus (36.8%) and smoking(26.3%) were the most common risk factors.Time parameters like mean onset to door time, door to image and door to needle time were 126 minutes, 29minutes and 66 minutes respectively, which were confirming with the international standards. Mean NIHSS was 11.1 and serial improvement was noted in the post treatment mean NIHSS scores at 1 hours, 24 hours and 7days with values of 8.6,8.0 and 7.7 respectively ( F=5.619,p=0.018). The mean mRS score was 3.5 and the follow up mRS at 1 month (2.4) and 3 months (1.7) (F=19.32, p<0.001) revealed significant functional improvement. The spearman test showed a positive correlation of age with all the serial post treatment NIHSS and mRS scores even when it did not affect the baseline NIHSS and mRS scores suggesting a poor response to tenecteplase with increasing age. Major improvement in mRS scores described as either a score of 0 or 1 or else a three-point improvement from baseline was seen in 47% (9) of thrombolysed patients and a major improvement in NIHSS scores was seen in 26% (5) patients. Symptomatic intracranial hemorrhage (sICH) was seen in only 5% of the study population.

Thrombolysis with tenecteplase is faster, safer and effective but the treatment response decreases with increasing age.
To assess and analyze the clinical outcome of conservative and operative management of head injury in acute subdural haematoma
Authors: Chaurasia I.D , Rathor Deepak
Published: March 2022

Traumatic acute subdural haematoma (SDH) continue to have high mortality & morbidity despite the advent of rapid transportation, CT Scan and Intensive care management. The general surgical procedures for Acute SDH is Craniotomy with removal of haematoma & decompressive craniectomy if necessary. This is a study based in department of surgery. After taking complete history and detailed examination and investigation (CT Scan) was be done. Decision of surgery was be taken by the consultant neurosurgeon of the acute Subdural Haematoma, involvement of aloquent areas and associated other injury of brain.200 patients with head injury who reported at casualty of Gandhi Medical College, and Hamidia Hospital, Bhopal.

In our study, Mode of Injury found to be Assault were 20%, Fall were 27% & RTA 53% in Conservative whereas Assault were 06%, Fall were 14% & RTA 80%.The chi-square statistic is 96.3397. The p-value is < 0.00001. The result is significant at p < 0.05. These findings indicate that the thickness/size of acute SDH significantly correlates with the type of management to be done for the patient.

Acute subdural haematoma is the major cause of significant morbidity and mortality due to traumatic head injury. Acute subdual haematoma is commonly associated with countercoup injuries and diffuse axonal injury (DAI). The clinical presentation in patients with acute SDH is related to raised ICP and the severity of DAI. C.T. Scan is the investigation of choice in patients with head injury.
Guillain-barré syndrome after purified vero cell rabies vaccination: An unusual case report
Authors: Shubhakaran Khichar , Bhargava Amita , Khoont Sanjay
Published: March 2022

Guillain-Barré syndrome (GBS) can be described as a collection of clinical syndromes that manifests as an acute inflammatory polyradiculoneuropathy with resultant weakness and diminished reflexes. Regarding pathophysiology of GBS, it is believed that autoimmunity- molecular mimicry plays a role in its pathogenesis. As the vaccines have an effect on the immune system it is reasonable that immunizations may be associated with subsequent GBS. Although rabies vaccines containing neural elements are very well known cause for GBS, no such positive correlation has been proven after newer formulations of rabies vaccine, derived from chick embryo cells. Here we report a case of GBS which developed after 5 weeks of anti-rabies vaccination (Purified Vero cell rabies vaccine) which was given after dog bite.
La fruticultura en el Alto Valle de Río Negro: origen, auge y deterioro, 1930-1965
Authors: Vera Andrés
Published: March 2022

La producción frutícola ubicada en la región del Alto Valle de la provincia de Río Negro, Argentina, se presenta –actualmente– como un modelo productivo en crisis a partir del deterioro socioeconómico y la desaparición de los pequeños productores característicos de la región. Sin embargo, es preciso mencionar que dicha producción, cuyos inicios se remontan a la década de 1930, pudo experimentar etapas de bonanza y crecimiento, perfilándose en sus primeras décadas como la principal actividad agropecuaria de la economía de la región. El presente artículo pretende explicar los diferentes hechos económicos y políticos que acontecieron durante el trayecto histórico de la producción frutícola, que posibilitaron la configuración de un contexto vulnerable para los pequeños y medianos productores, el cual se evidencia definitivamente en la década posterior a 1955. De esta forma, se sostiene que la construcción histórica de una relación asimétrica entre empresas comercializadoras y productores representó la principal causa de vulnerabilidad.
The Performance of Thai Sign Language Recognition with 2D Convolutional Neural Network Based on NVIDIA Jetson Nano Developer Kit
Authors: Gedkhaw Eakbodin
Published: March 2022

Thai Sign Language Recognition is a Thai Sign Language learning computer recognition. The system constructs an architecture of T-SLR by TSR- 2DCNN based on NVIDIA Jetson Nano Developer Kit. It is a novelty of automatic translation TSL innovation and reveals the performance of feature extraction and classification to reduce crashed system, overloaded or automatic reboot while complicated processing occurs. The dataset contains 7 gestures in TSL, training images are 7,000 images and validation images are 700 images. The result compares with many techniques as shown that TSR-2DCNN can increase the performance of TSLR in real-time, effectiveness with an accuracy of 0.9914 and loss of 0.03537.
Engineering Education and Learning outside the Classroom through MOOCs: Student Assessment
Authors: Tarasova Olga , Bykov Aleksei , Likhouzova Tetiana , Petunina Irina
Published: March 2022

The development of engineering students is more often associated with classroom learning, but there is an increasing need for online learning. This study tests students' impressions of a specialized massive open online course. Engineering students from the Russian Federation and Ukraine (n = 295) were involved to the empirical part. According to the results, 84% of the participants had difficulty in using the knowledge gained during the course. In this paper, the authors suggest ways of improving online courses for students so that what they learn can be put into practice. On average, it will take universities 4.5 - 8 years to completely switch from face-to-face classes to the use of MOOCs.
Hard Discount Formats Service Quality Assessment Model in Colombia
Authors: M. Andrade Juan , Velez Fredy , Ramírez Elías
Published: March 2022

In this article, the construction of an evaluation model of the quality of the service of hard discount stores in Colombia was carried out. Thus, a quantitative study was carried out, under the deductive and descriptive method, with its own instrument designed and supported by the globally accepted Servqual and Servperf models, with Likert-type questions, to measure customer perception. In this regard, around five thousand surveys were applied in the main cities of the country, for the validation of the instrument as the information processing, the quantitative software SPSS-26 and its complement the AMOS were used. The designed model was made up of seven dimensions, namely: tangible elements, reliability, empathy, security, responsiveness, image and loyalty. Finally, it concludes by highlighting the aspects that were considered most relevant for the customers of the discounter’s stores.
The effect of additional staple in the tibial fixation of anterior cruciate ligament reconstruction: a biomechanical study in sheep tibia
Authors: OTO Onur , BOMBACI Hasan , BOZDAĞ Ergun , ERTAN BİRSEL Sema , BAYIR Dilara , ORAL Rıdvan Mete
Published: March 2022

Objectives: The aim of this study was to evaluate the necessity of staple use and the importance of screw diameter in the anterior cruciate ligament (ACL) reconstruction.
Methods: Twenty-eight sheep hind legs were divided into four groups in terms of tibial side fixation type as 7 mm bioabsorbable screw (Group 1), 7 mm bioabsorbable screw and staple (Group 2), 8 mm screw (Group 3), and 8 mm screw and staple (Group 4). The maximum force causing insufficiency in the graft, and the fixation strength between the groups were recorded. The results were compared among the groups.
Results: As a result of the statistical analysis regarding the necessity of using staple, group 2, with 7 mm screws and staple, was found to be significantly more resistant than group 1 (p = 0.018). In consequence of the biostatistics study, staple use was found not to create a statistically significant difference between group 3 in which an 8 mm bioabsorbable screw was used and group 4 (p = 0.805). In the statistical study to understand the significance of screw diameter, the samples of group 1 and group 3, in which no staple was used, were compared. It was found that group 3 samples with 8 mm screws had higher strength than those with 7 mm screws (p = 0.011). Between group 2 and group 4 in which a staple was used, despite the increase in screw diameter, the value of maximum strength had no remarkable difference statistically (p = 1.00).
Conclusions: Fixation strength is higher when fixation was done with a screw 1 mm larger than tibial tunnel diameter. However, using either a screw with 1 mm wider than tibial tunnel diameter and the screw in the same diameter with the tibial tunnel and additional staple have similar fixation strength on the tibial side. Therefore, we conclude that screw width is more important in maintaining stability of the graft fixation.
Tendencias y perspectivas del marketing en las pymes
Authors: Suárez Pérez Juan Carlos , Pérez Barral Osmany
Published: March 2022

La investigación comprende y analiza la situación actual de las estrategias de marketing en las pequeñas y medianas empresas (pymes), pues se ha evidenciado que están diseñadas de manera empírica, es decir, sin un sustento técnico que garantice el éxito de la planificación para su desarrollo y sostenibilidad. Asimismo, el estudio profundiza en la realidad de estas organizaciones, y en las tendencias y perspectivas del marketing que se ajusten a sus necesidades para hacerlas más competitivas y se posicionen en el mercado. En este sentido, el objetivo de este artículo es analizar las tendencias y perspectivas del marketing en las pymes de la ciudad de Ambato. Para ello, se aplicó una metodología cualitativa, que permitió contextualizar e indagar información natural, holística y flexible. Los resultados se enmarcan en la determinación de la planificación estratégica de las pymes en la ciudad que fue el objeto de estudio. Se tuvo la finalidad de mejorar el funcionamiento, consolidar su marca y lograr digitalizar en el futuro los negocios más allá del tamaño que tengan. Todo esto contribuye a su propio posicionamiento mediante la optimización de los recursos, la mejora de la tecnología, y la posibilidad de aplicar estrategias más eficientes que las hagan crecer y expandirse.
De l’impact des représentations sociales sur l’apprentissage du français dans le contexte tunisien
Authors: Hmissi Wafa
Published: March 2022

Dans le contexte tunisien, l’apprentissage du français langue étrangère rencontre plusieurs difficultés. Pour pouvoir déterminer ces obstacles, nous avons mené une enquête qualitative (l’entretien semi-directif) pour délimiter, catégoriser et examiner les représentations sociales qui constituent non seulement un frein à l’apprentissage du français mais aussi un obstacle à l’ouverture sur autrui. Les entretiens semi-directifs sont au nombre de 9, dirigé l’un séparément de l’autre sur des élèves dont l’âge moyen va de 16 à 18 ans. La durée de chaque entretien varie entre 25 et 35 minutes. Cette enquête exploratoire permet de mettre le point sur le dysfonctionnement linguistique permettant, par la suite, d’ajuster le dispositif didactique selon les besoins et les attentes des apprenants. Nos résultats révèlent que parmi les freins à l’apprentissage du français : le rapport conflictuel historique entre le Français, ancien colonisateur et le Tunisien et le facteur identitaire. En contestant la langue de l’autre, l’élève présume, par là-même, mettre en valeur sa langue maternelle, sa culture et soi-même.

 

In the Tunisian context, learning French as a foreign language encounters several difficulties. To be able to determine these obstacles, we carried out a qualitative survey (the semi-directive interview) to delimit, categorize and examine the social representations which not only constitute an obstacle to learning French but also an obstacle to opening up to others. The semi-structured interviews are 9 in number, directed one separately from the other on pupils whose average age ranges from 16 to 18 years. The duration of each interview varies between 25 and 35 minutes. This exploratory survey makes it possible to focus on the linguistic dysfunction allowing, subsequently, to adjust the didactic device according to the needs and expectations of the learners. Our results reveal that among the obstacles to learning French: the historical conflicting relationship between the French, former colonizer and the Tunisian and the identity factor. By contesting the language of the other, the student, presumes, thereby, to highlight his mother tongue, his culture and himself.
Aprendizaje Sincrónico y Asincrónico del Año 2020: el Caso del Instituto Tecnológico de Saltillo, Coahuila
Authors: Urbina Valdes Leticia , Mellado Siller Jesús Francisco , Reyes Ruiz Edith
Published: March 2022

Esta investigación tiene como objetivo, encontrar las principales diferencias entre la educación sincrónica y la asincrónica, el estudio se llevó a cabo con las carreras de ingeniería del Instituto Tecnológico Nacional de México, Campus Saltillo, ubicado en el estado de Coahuila; se realizaron trabajos de investigación acerca de lo que son los antecedentes que se tienen registrados en las bases de datos, de ellas se obtuvieron las variables que se consideraron se deberían de medir en cada una de las formas de enseñanza; se realizó un análisis factorial para establecer el sustento de cuáles son las diferencias y si estas son significativas. Los resultados arrojaron en las saturaciones significativas de los factores y quedó de manifiesto, que si bien hay concordancias también existen diferencias en las maneras de enseñanza y éstas son los resultados importantes del estudio; ya que pueden ser consideradas en las planeaciones de estructuras de enseñanza tanto de forma presencial como de forma a distancia.

 

This paper focuses on identifying the main differences between synchronous and asynchronous education. The study was carried out at the National Technological Institute of Mexico, Campus Saltillo, which is located in the state of Coahuila. The research work was conducted based on the records that were registered in the databases, and the measured variables that were considered in the forms of education were obtained. A factorial analysis was utilized to establish what the differences are and if they are significant. The results showed the significant saturations of the factors and it became clear that although there are concordances, there are also differences in the ways of teaching. The results of the study should be considered in the planning of teaching structures both in person and remotely.