bluuebunny/crossref_metadata_2025 huggingface dataset:
No Causal Links Between Lifetime Estradiol Exposure and Female’s Brain and Mental Health – A Mendelian Randomization Study
Authors: Oppenheimer Hannah , van der Meer Dennis , Schindler Louise , Crestol Arielle , Westlye Lars T. , de Lange Ann-Marie G , Barth Claudia
Published: July 2024

Estradiol, the predominant sex steroid in females, has been implicated in the development of depression and Alzheimer’s disease – two disorders that disproportionately affect females. Yet, while some studies suggest protective effects of estradiol on brain health and mental health, results are inconsistent partly due to methodological challenges of observational studies such as confounding and reverse causation. In this preregistered study, we examined whether estradiol levels and factors related to lifetime estradiol exposure are causally linked to brain age gap (predicted brain age relative to chronological age), AD risk, and depression risk in females. The factors related to estradiol exposure included reproductive span, age at menarche, age at menopause, number of childbirths, oral contraceptive use, HRT use, history of hysterectomy, and history of oophorectomy. To overcome some challenges of observational studies, we tested for causal associations by conducting two-sample Mendelian randomization analyses using female-specific summary statistics from previously conducted and newly run genome-wide association studies (GWAS). This included running the first female-specific GWAS on brain age gap and a GWAS on estradiol levels. No significant causal associations were found between estradiol levels, or any factors related to lifetime estradiol exposure and brain age gap, AD, or depression. Therefore, the results do not support causal links of estradiol with mental and brain health in females. Future studies should assess other influencing factors, as well as implement sex-specific, causal frameworks to examine potential effects of hormonal fluctuations and periods of increased susceptibility to sex steroids such as the perimenopausal period.
Theory of Machine 2.0: Artificial Versus Artificial Intelligence
Authors: Rebholz Tobias R.
Published: July 2024

Most research on augmented judgment and decision-making is human-centered. Specifically, Theory of Machine is a conceptual framework for describing and analyzing people’s lay theories about how human and algorithmic judgment differ. Reminiscent of the Theory of Mind, it conceptualizes the idea of ascribing thought processes or mental states to algorithms. However, based on their own perceptions, past personal experiences, and shaped by public media, people may conceive of humans and algorithms as functionally distinct ontological entities. Therefore, research on augmented judgment and decision-making should also focus on the differences between various algorithms in terms of (cognitive) abilities and behavior. In this article, several agendas for future research are proposed that explicitly consider people’s diverse interactions with various decision-support and artificial intelligence systems in their daily lives. Such primarily algorithm-centric research will help to gain insights into a more fine-grained Theory of Machine that also distinguishes between different levels of algorithmic fairness, transparency, and explainability. Ideally, a better understanding of how people mentalize about algorithmic behavior can also be used to improve algorithmic augmentations of human judgment and decision-making.
News on Social Media Boosts Knowledge, Belief Accuracy, and Trust: A Field Experiment on Instagram and WhatsApp
Authors: Altay Sacha , Hoes Emma , Wojcieszak Magdalena
Published: July 2024

Many worry that social media leaves people uninformed or even misinformed. Can people actually learn from following the news on social media? We conducted a preregistered two-wave online field experiment in France and Germany (N = 3,395) to estimate the effect of following the news on Instagram and WhatsApp. Participants were asked to follow two accounts for two weeks and activate the notifications. In the treatment condition the accounts were news-related whereas in the control they were not. Our results show that news consumption on social media has positive consequences: it enhances news knowledge, participants’ ability to discern true from false news stories, awareness of true news stories, as well as trust in the news. The treatment had no significant effects on feeling of being informed, political efficacy, affective polarization, and interest in news or politics. These results suggest that, contrary to popular belief, people actually learn from news on social media and that this form of news consumption should not be dismissed or disdained. While some forms of social media use are harmful, others are positive and can be leveraged to foster a well-informed society.
Increased threat learning after social isolation in human adolescents
Authors: Towner Emily , Thomas Kirsten , Tomova Livia , Blakemore Sarah-Jayne
Published: July 2024

In animal models, social isolation impacts threat responding and threat learning, especially during development. This study examined the effects of acute social isolation on threat learning in human adolescents using an experimental, within-participant design. Participants aged 16-19 years underwent a session of complete isolation and a separate session of isolation with virtual social interactions, counterbalanced between participants, as well as a baseline session. At baseline and following each isolation session, participants reported their psychological state and completed a threat learning task in which self-report ratings and physiological responses to learned threat and safety cues were measured. Threat learning increased after both isolation sessions in two ways. First, participants found the learned threat cue more anxiety-inducing and unpleasant after isolation compared to baseline. Second, during threat extinction, electrodermal activity was partially elevated after isolation compared to baseline. Further, the results suggested that isolation influenced threat learning through state loneliness. Threat learning is central to threat-related disorders including anxiety, phobias, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD), and our findings suggest that isolation and loneliness in adolescence might increase vulnerability to the emergence of these disorders through increased threat learning.
Individuals with Lower Numeracy show more Extreme and Mid-point Responding: An IRTree Based Approach
Authors: Block Jared , Bjälkebring Pär , Loran Zachary , Smith Stephanie Marie , Ťápal Adam , Montoya Amanda Kay
Published: July 2024

Participants are asked to respond on Likert-type scales to measure their opinions, emotions, or experience. Likert-type scales can be affected by response styles, the tendency to respond consistently regardless of question content. Common response styles include extreme and midpoint responding (overuse of end and middle options, respectively). Limited research aims to understand response style's psychological underpinnings. This study evaluates whether numeracy, an individual’s ability to understand and work with numbers, can predict extreme and midpoint responding. Data from the Understanding America Study (N = 7,057) is used to model numeracy and response style, derived from the Big-5 Personality Questionnaire, using IRTrees. IRTrees combine item response theory (IRT) and decision trees, to allow for multidimensional models of single item responses. Results showed that lower numeracy corresponds with higher rates of mid-point and extreme response styles. The relationship between numeracy and extreme responding persists after controlling for education, but the same is not true for midpoint responding. We discuss implications for the use of Likert-type items, the study of numeracy and numeracy-related factors, and the psychology of survey responding.
Profiling Societal Disengagement in the New Zealand Population
Authors: Wigg Kaitlyn , Cone Deborah Hill , Lilly Kieren James , Zubielevitch Elena , Satherley Nicole , Osborne Danny , Sibley Chris G
Published: July 2024

Despite growing concerns about declining social cohesion, no systematic analyses have assessed how societal disengagement manifests in New Zealand. The present study addresses this oversight by examining societal disengagement in a large, nationwide random sample of New Zealand adults collected in 2021/2022 (N = 34,131). Using latent profile analysis, we identified seven profiles in the population that differed on seven indicators of disengagement: feeling wronged, powerless, meaningless, disconnected from community, financially deprived and pessimistic, and wary of authority. Two enfranchised profiles captured most of the sample (68.9%), suggesting most people are generally connected to society. However, we identified a small Anomic profile (6.4%) in which members experienced alienation and disengagement across indicators. We also identified four additional profiles reflecting combinations of enfranchisement and disengagement. The seven profiles differed across demographic characteristics and reflect qualitative distinctions between the socially enfranchised and disengaged in New Zealand.
Forest Encroachment and Agriculture Land Abandonment in the Context of Land Cover Change in Kailali
Authors: Balayar Suresh , Ghimire Motilal , Paudel Basanta
Published: July 2024

Land use land cover (LULC) area has been changing for many decades in the Kailali district but has little been researched. The study aims to examine the spatial and temporal changes of LULC from 1978 to 2021, carrying out major driving factors of forest cover change regarding forest encroachment and abandonment. The researcher employed a mixed-method approach to accomplish this study. Field observation, household survey with 45 participants, Key Informant Interviews (KII) with three participants, and five Focus Group Discussions (FGD) were used as research tools to collect the data. Moreover, the researcher used books, journal articles, official reports, and related previous empirical studies as secondary data [Land Resource Mapping Project (LRMP) data were used to screen LULC status of 1978 and 1990, and digitization on Google Earth Pro to prepare LULC data for 2000 and 2021]. The findings of the study revealed that the forest cover area of the Kailali district was in a decreasing trend [ for instance in 1978 the area of forest cover was 75.38%, in 1990 it was 66.51% in 2000, and was 65% in 2021]. In contrast to forest cover, the agricultural [settlements and infrastructures] land area was on an increasing trend which was followed by 21.77%, 30.28%, 31.75%, and 32.25% in each period. The study also found that the changing rate of forest cover and the agricultural land have been decreasing. Further, the research found the major drivers of forest cover change were encroachment and agricultural land abandonment. In addition, population growth, migration, poverty, development activities, natural hazards, resettlement, public utilities, weak implications of policy, and illegal activities were also the major causes of forest cover change. The research implies that both forest encroachment and land abandonment should be controlled, and are to be considered by the stakeholders.
Postoperative Complications of Radical Cystectomy and Urinary Diversion using Clavein-Dindo Classification in Tertiary Care Hospital
Authors: Pokharel Bharatmani , Lamichhane Nirmal , Nepal Umesh , Pokharel Gyan Prasad , Gharti Binod Babu , Jalan Aditya
Published: July 2024

Background: The gold standard treatment for muscle-invasive transitional cell carcinoma of the bladder is radical cystectomy (RC) with urine diversion. The mortality and morbidity rates ranged from 0 to 9.0% and 30 to 70%, respectively in various reports. Among various classifications of complications, the Clavien–Dindo classification (CDC) is applicable to most procedures for comprehensive surgical outcome assessment. The study will be helpful to identify the potential early postoperative complications and possibly minimize the morbidity and mortality of this surgery in the future.
Materials and Methods: Prospective study of 60 patients with Bladder Cancer fulfilling the inclusion criteria who underwent radical cystectomy with urinary diversion was collected from January 2023 to June 2024 at B.P. Koirala Memorial Cancer Hospital. The various demographic data and perioperative parameters were recorded. The early complications defined as the complications during hospitalization or within 30 days of surgery were enlisted and then classified according to Clavein-Dindo Classification. Data were analyzed using SPSS 25 software.
Results: Many patients, 56 (93.33%) patients had some form of postoperative complications of radical cystectomy with urinary diversion. Of these, GI complications were (41.7%), infections related (21.7%), Wound related (11.7%) and others. 23 (38.33%) patients had high grade (≥ Grade III) complications. The mortality rate was 6.7%.
Conclusion: Radical cystectomy is complicated surgery involving at least 2 systems in the body ie genitourinary and Gastrointestinal systems. So it is associated with higher rate of morbidity.
Bauxite Resource Estimation Analysis Using Ordinary Kriging and Inverse Distance Weighting in West Kalimantan
Authors: Wahid Muhammad Abdul , Winarno Eddy
Published: July 2024

PT X is a mining company engaged in bauxite mining which is located in Nanga Tayap District, Ketapang Regency, West Kalimantan Province. Currently the company is carrying out further exploration activities to find potential bauxite resources which will later be upgraded into reserves for mining. In resource estimation, there are several methods that can be used, such as the Nearest Neighbor Point method, Inverse Distance Weighting, and Ordinary Kriging. This research aims to analyze two resource estimation methods, namely Inverse Distance Weighting and Ordinary Kriging for resource estimation and choose the best method based on geological conditions and RMSE value parameters. Based on the results of this research, the estimated value of bauxite resources using the IDW method obtained a tonnage of 1,046,874.99 tons with an average Al₂O₃ content of 47.28%. Meanwhile, the estimated bauxite resource value using the OK method obtained a tonnage of 1,046,875.01 tonnes with an average Al₂O₃ content of 48.15%. Based on the calculation of the Root Mean Squared Error (RMSE) value from the two methods, the respective RMSE values were obtained, namely IDW = 0.0001263 and OK = 0.0084145. From these results it can be concluded that the best method for estimating bauxite resources in the Enggang block is the Inverse Distance Weighting (IDW) method.
Geological History Reconstruction using Stratigraphic Analysis: A Case Study of Kampung Baru, West Sumatra
Authors: Putri Helen Dwi , Setiawan Budhi , Rochmana Yogie Zulkurnia
Published: July 2024

The reconstruction of geological history includes the development of rocks and volcanic deposits on a depositional pattern consisting of various types of sedimentary materials accumulated over a long time, which involves depositional changes. Depositional changes require geological comprehension in analyzing and understanding the geological processes involved in their evolution. For this reason, stratigraphic analysis is a very relevant approach to discussing rock layers, including significant environmental changes during their geologic history. The purpose of this research is to find out the geological processes that have contributed to the formation of the earth in the past. The method in this research is a stratigraphic analysis carried out from field observation data carried out directly at the outcrop. Deposition began with the re-deposition of the Pre-Tertiary (Triassic)-aged Porphyry Quartz Dasite Formation. In the Late Oligocene Epoch, the Sawahtambang Formation was deposited, which formed in the braided river characterized by the presence of sedimentary structures in the form of lamination and cross lamination. In the Early Miocene to Middle Miocene, the transgression process occurred, where the change in deposition was caused by the supply of larger land sediments that caused the deposition of the Ombilin Formation to be deposited in the marine environment of the Transition-Nerritic Edge based on the bathymetry results. The research results are expected to enable geological information to gain in-depth knowledge and experience about the history of deposition and assist in geological modeling.
Errors in the Introduction of Isometric Coordinates and Violation of the Property of Conformality of the Triaxial Ellipsoid Projections
Authors: Fleis Maria E. , Nyrtsov Maxim V. , Sokolov Anton I. , Stooke Philip J.
Published: July 2024

The purpose of this study is to show that some coordinate systems previously described as isometric are in fact not isometric, and as a consequence, map projections derived from them do not show the expected characteristics, especially conformality. Definitions and methods of the mathematical theory of surfaces are used. The article discusses two methods of specifying coordinate systems on the surface of the triaxial ellipsoid, erroneously called isometric. A consistent mathematical study of each of them based on the initial definition of isometric coordinates showed that in the first method, the corresponding coordinate system is not orthogonal, much less isometric. In the second method, the coordinates are determined using integration, and the result of the integration depends on the path of this integration. This ambiguity shows that this method is also incorrect. The considered coordinate systems allow the creation of new projections, but these projections are not conformal. As a result of the study, errors in determining isometric coordinates were shown and proven, which in earlier studies led to a violation of the properties of projections. This analysis should lead to the development of truly conformal projections of triaxial ellipsoids. For clarity maps and cartographic grids are presented.
Indiana
Authors: Sweetland Scott Rodger , Milligan C. Drew
Published: July 2024

This report about Indiana school funding relates to budgetary changes in the state’s school funding priorities and technical changes to its state aid to schools formula. Pressing issues that affect school funding as well as public policy dimensions of alternatives to traditional public schools are considered. The most pressing need for the schooling system that is mediated by the school funding program remains increasing the labor market supply of highly credentialed teachers. The most evident public policy trend is the continuing expansion of free market-based school choice options.
Sistem Deteksi Stunting Sebagai Program Intervensi Gizi di Kelurahan Teluk Pucung
Authors: Khalida Rakhmi , Sulistio Irvan , Soko Ajie , Ali Isnan , Ramadhan Reyno Imzaki , Ramadhan Raka , Mubarok Faros , Pangabean Yobel Hardongan , Khusaini Helmi Nur , Nugroho Danang Adityo , Anasyah Bayu Adji
Published: July 2024

The prevalence of stunting in Indonesia is currently at 21.6%, which is down from the initial value of 24.4% in 2022. There is a failure in the process of improving nutritional status that causes babies and toddlers to indicate stunting. Stunting is a condition where children experience growth disorders, so that their height is not in accordance with their age as a result of chronic nutritional problems, namely lack of nutritional intake for a long time. Data shows that stunting in children can have a long-term impact on their health and development, creating serious challenges in achieving the full potential of future generations. Insufficient intake of adequate nutrition, unequal access to quality health services, and supported by healthy eating practices and lack of a supportive environment are the main factors that trigger high stunting rates, demanding integrated interventions to address the root of the problem. Bhayangkara University of Greater Jakarta as a private sector that should collaborate in efforts to improve the nutritional status of the Indonesian people carried out real lecture work (KKN) in one of the villages in Bekasi City, namely Teluk Pucung village. A holistic approach that considers social, economic, and educational factors in efforts to improve nutritional status is essential. Intervention programs should not only focus on providing nutritious food, but also on family economic empowerment, increasing mothers' knowledge about nutrition and child health and improving access to quality health services.
Implementasi Game Tebak Gambar Binatang Berbasis Android Sebagai Media Pembelajaran Anak Usia Dini
Authors: Prasetya Renaldi Primaswara , Wahyuni Febriana Santi , Rudhistiar Deddy
Published: July 2024

The increasingly rapid development of technology, especially mobile phone devices has targeted all groups, including young children aged 3 to 5 years, so like it or not,parents have to supervise their children. But in reality, technology cannot be avoided. As a parent, the most important thing right now is how to ensure that the mobile devices playing with children can be handled well and have a positive impact on their children, although supervision is still needed. Supervision of children who are already at school cannot be carried out continuously. At school, parents can only expect for the teachers as their second parents. Teachers as educators must be able to provide understanding to Kindergarten children, thus the use of cellphones can be used for positive things, one of which is by providing mobile game-based learning media. The problem is that there are only a few mobile applications in the form of games that provide simple learning media for Kindergarten children. Through this service, an Android-based educational game of animal picture guessing will be designed and developed as a learning medium for children aged 3-5 years. To determine the impact of implementing the application, implementation and testing were carried out, where the average System Usability Scale (SUS) score from 15 respondents was 88.33, and when referring to the usability scale value range it can be concluded that the animal picture guessing game that has been developed falls into the category acceptable or well accepted with a fairly significant impact category. Meanwhile the functionality also meets the needs of its users.
Peningkatkan Kemampuan Seni AUD Melalui Teknik Kolase Berbasis Kearifan Lokal Kota Palembang
Authors: Firabeliya Nanda Audry , Dezyemita Tarsya Rahma , Pasha Aulia Shafira , Arista Sindy Agustina , Kania Refi , Jannah Adinda Mutiara , Pagarwati Lia Dwi Ayu , Zulaiha Dara
Published: July 2024

Art development is one aspect that needs to be paid attention to from an early age. Because art can be used as a forum for children to express their imagination and self-expression. The aim of this research is to obtain information on the use of collage techniques to improve children's artistic abilities at Kartika II-I Kindergarten. The research uses classroom action with the implementation stages adopting the Kemmis & Tagart model including 1) planning, 2) implementation, 3) observation and 4) reflection. The implementation of this model was carried out in 2 cycles, with 2 meetings in each cycle. The research subjects were 16 children aged 4-5 years at Kartika II-I Kindergarten. Researchers in collecting data used interview and observation techniques. After the data is obtained, it will be analyzed using qualitative and quantitative data analysis techniques. The research results obtained a score in pre-action of 56.5 and after action in cycle 1 of 68.1 and cycle 2 of 78.3. Thus, the researchers concluded that using collage techniques can improve children's artistic abilities.
Regulation of retrotransposons in Drosophila melanogaster somatic tissues
Authors: Milyaeva P. A. , Kukushkina I. V. , Lavrenov A. R. , Kuzmin I. V. , Kim A. I. , Nefedova L. N.
Published: July 2024

Regulation of retrotransposon activity in somatic tissues is a complex mechanism that is still not studied in details. It is strongly believed that siRNA interference is main mechanism of retrotransposon activity regulation outside the gonads, but recently was demonstrated that piRNA interference participates in retrotransposon repression during somatic tissue development. In this work, using RT-PCR, we demonstrated that during ontogenesis piRNA interference determinates retrotransposon expression level on imago stage and retrotransposons demonstrate tissue-specific expression. The major factor of retrotransposon tissue-specific expression is presence of transcription factor binding sites in their regulatory regions.
Stochastic packaging of Cas proteins into exosomes
Authors: Ponomareva N. I. , Brezgin S. A. , Kostyusheva A. P. , Slatinskaya O. V. , Bayurova E. O. , Gordeychuk I. V. , Maksimov G. V. , Sokolova D. V. , Babaeva G. , Khan I. I. , Pokrovsky V. S. , Lukashev A. S. , Chulanov V. P. , Kostyushev D. S.
Published: July 2024

CRISPR/Cas systems are perspective molecular tools for targeted manipulation with genetic materials, including gene editing, regulation of gene transcription, modification of epigenome etc. While CRISPR/Cas systems proved to be highly effective for correcting genetic disorders and treating infectious diseases and cancers in experimental settings, the clinical translation of these results is hampered by the lack of efficient CRISPR/Cas delivery vehicles. Modern synthetic nanovehicles based on organic and inorganic polymers have many disadvantages, including toxicity issues, the lack of targeted delivery, complex and expensive production pipelines. In turn, exosomes are secreted biological nanoparticles exhibiting high biocompatibility, physico-chemical stability, and ability to cross biological barriers. Early clinical trials found no toxicity associated with exosome injections. In recent years, exosomes have been considered as perspective delivery vehicles for CRISPR/Cas systems in vivo. The aim of this study was to analyze the efficacy of CRISPR/Cas stochastic packaging into exosomes at several human cell lines. Here, we show that Cas9 protein is effectively localized into the compartment of intracellular exosome biogenesis, but stochastic packaging of Cas9 into exosomes turns to be very low (~1%). As such, stochastic packaging of Cas9 protein is very ineffective, and cannot be used for gene editing purposes. Developing novel tools and technologies for loading CRISPR/Cas systems into exosomes is required.
МЕДИЙНО-ИНФОРМАЦИОННАЯ ГРАМОТНОСТЬ
Authors: ГУДИЛИНА С.И.
Published: July 2024

В учебном пособии рассмотрены вопросы формирования медийно-информационной грамотности бакалавров как общекультурный подход для развития универсальных и общепрофессиональных компетенций, направленных на осмысленное взаимодействие с медийными и информационными ресурсами, использование их в педагогической практике, а также создание медиаресурсов для учебных целей. Развитие медиаинформационных компетенций рассматривается в условиях формального обучения. Учебное пособие рассчитано на студентов бакалавриата педагогического вуза художественно-графического факультета. Представляет интерес для аспирантов, педагогов высшей школы, средних общеобразовательных и профессиональных учебных заведений.
FAKTOR-FAKTOR YANG MEMPENGARUHI POST USE TRUST DAN CONTINUOUS USE INTENTION APLIKASI SATU SEHAT
Authors: Wahyuningtyastuti Indrajati , Candiwan Candiwan
Published: July 2024

Satu sehat yang merupakan layanan Kesehatan publik yang disediakan pemerintah Indonesia untuk memberikan pelayanan yang lebih efektif dan efisien. Satu sehat yang awalnya digunakan pada masa pandemi Covid-19 dengan nama Peduli Lindungi sempat memiliki jumlah pengguna mencapai 105 juta pengguna akan tetapi pada Maret 2023 turun drastis menjadi 1 juta pengguna saja. Pada penelitian ini akan menyelidiki dan menganalisis dampak dari perceived service quality, perceived risk, trust in government, dan trust in internet terhadap post use trust Aplikasi Satu Sehat/Peduli Lindungi dan dampak dari post use trust, perceived usefulness, dan satisfaction terhadap niat penggunaan berkelanjutan. Data yang dikumpulkan pada penelitian ini melalui kuesioner online dan mencapai jumlah sampel sejumlah 256 orang untuk pengguna Satu Sehat/Peduli Lindungi. Hasil penelitian menunjukkan bahwa indikator yang mempengaruhi  post use trust meliputi perceived risk, trust in government, dan trust in internet serta yang mempengaruhi niat penggunaan berkelanjutan meliputi post use trust, satisfaction, dan perceived usefullness. Sehingga pada penelitian ini menyimpulkan bahwa niat pengggunaan berkelanjutan belum terlalu tinggi. Sehingga pada penelitian ini menyarankan penyebaran atau sosialisasi terkait aplikasi layanan kesehatan publik satu sehat ini dilakukan lebih meluas dengan diberikan sosialisasi serta bantuan teknis penggunaan.
THE INFLUENCE OF TRAINING AND CAREER DEVELOPMENT ON EMPLOYEE PERFORMANCE WITH EMPLOYEE ENGAGEMENT AS AN INTERVENING VARIABLE
Authors: Putri Aulia , Harini Sri , Ismartaya Ismartaya
Published: July 2024

A company can be said to be successful when the performance of the company's employees is good. Factors that influence employee performance are training, career development and employee engagement. This research aims to determine the influence and response to training, career development, employee engagement and employee performance. This research method is quantitative research with a simple random sampling technique. Data were collected through distributing questionnaires which were tested through validity, reliability, multicollinearity, heteroscedasticity, coefficient of determination, t test, and Sobel tests. The results of this research are that employee performance and employee involvement are in the quite high category, training and career development are in the quite good category. In addition, training and career development have a direct effect on employee engagement and have an indirect effect on employee performance through employee engagement.
EVALUASI PENDIDIKAN KEWIRAUSAHAAN DI UNIVERSITAS
Authors: Raudhatul Zannah Ghevira Nazla , Ghina Astri
Published: July 2024

Universitas Telkom telah mengintegrasikan kewirausahaan sebagai unsur yang tak terpisahkan dalam proses pendidikannya, terutama dalam konteks memenuhi rencana Visi Misi Universitas. Penilaian ini bertujuan untuk mengevaluasi Pendidikan kewirausahaan dari kelompok mahasiswa MBTI angkatan 2020 yang telah menyelesaikan perjalanan pembelajaran kewirausahaan. Secara khusus, penelitian ini berfokus pada Fakultas Ekonomi dan Bisnis dalam program Manajemen Bisnis Telekomunikasi Informatika (MBTI). Tujuan penelitian ini adalah untuk mengetahui efektivitas pelaksanaan pendidikan kewirausahaan di program studi MBTI. Selain itu penilaian ini juga bertujuan untuk dan mengetahui faktor-faktor yang mempengaruhi menurunnya minat berwirausaha dari mahasiswa MBTI angkatan 2020 yang telah menyelesaikan proses pembelajaran kewirausahaan dengan menggunakan metode EEP (Entrepreneurship Education Programs dimana dalam pelakasanaanya peneliti mewawancarai 6 narasumber yaitu 3 Dosen pengajar dan 3 mahasiswMBTI angkatan 2020. Hasil dari penelian menjelaskan bahwa terdapat 5 variabel yang menjadi hasil dan temuan bagi Evaluasi Pendidikan Kewirausahaan di Universitas
PENGARUH TINGKAT PENDIDIKAN DAN PEMAHAMAN AKUNTANSI TERHADAP KUALITAS LAPORAN KEUANGAN UMKM KELURAHAN SUKA MAKMUR
Authors: Nabila Syifa , Hayati Nur
Published: July 2024

Analisis dilakukan demi memastikan impresi parsial serta simultan antar tingkat pendidikan, pemahaman akuntansi, dan kualitas laporan keuangan. Total sampel mencapai 60 responden, serta populasinya yakni UMKM bidang kuliner di Kelurahan Suka Makmur periode bulan Ramadhan. Data primer serta sekunder, dikumpulkan dari berkas pelengkap Kantor Kelurahan Suka Makmur dan seluruh pernyataan responden. Penelitian ini bersifat kuantitatif. Pengujian instrumen, asumsi klasik, regresi linier berganda, serta hipotesis selaku prosedur analisis informasi riset ini. SPSS v29 berperan mengolah semua data. Temuan penelitian ini membuktikan model parsial tingkat pendidikan tidak mempengaruhi kualitas laporan keuangan, namun pemahaman akuntansi memberi pengaruh atas kualitas laporan keuangan, dan impresi simultan tingkat pendidikan dan pemahaman akuntansi mempengaruhi kualitas laporan keuangan. Sebagaimana hasil koefisien determinasi sebesar 0,177 atau variabel dependen terpengaruh 17,7% atas variabel independen, namun sisanya 82,3% dijabarkan oleh aspek lain.
Vibration Stimulation to Increase Milk Production in Puerperal Mothers
Authors: Raraswati Rhela Panji , Wijayanti Krisdiana , Hendriyani Heni
Published: July 2024

Breast milk is the best food for babies, but insufficient production can hinder breastfeeding. Many mothers face challenges with milk production, preventing optimal breastfeeding. This study aims to innovate and develop a vibration-based electric massage device to enhance breast milk production and analyze its effectiveness based on baby weight indicators. The research employs a quantitative method with a Quasi-Experimental design, divided into an intervention group and a control group. A random sampling technique selected 46 respondents, split evenly between the two groups. The intervention group received breast care using the vibration-based device, while the control group received standard breast care for 14 days. Breast care was administered twice daily for 2-3 minutes. Baby weight was measured at 14, 21, and 28 days. Tools to measure energy intake, protein intake, and fluid intake utilized food recall, and breastfeeding frequency was measured by a scale. Psychological status was assessed using the DASS questionnaire. Data analysis included Repeated Measure ANOVA and Independent Simple T-Test. Results indicated a significant difference in breast milk production based on baby weight between the intervention and control groups (p=0.000). The mean weight difference between the groups was 200.21 grams, favoring the intervention group. Increased breast milk production was not influenced by confounding variables such as energy intake, protein intake, fluid intake, breastfeeding frequency, and psychological status. In conclusion, the developed vibration-based electric massage device effectively increased breast milk production, evidenced by significant weight gain in babies within the intervention group compared to the control group (p=0.000).
Nurses Experience of Prone Position in The Absence of Positioning Tool, and Suggestion of Prone Position Tool: A Phenomenology Study
Authors: Sriyono Sriyono , Zulkarnain Hakim , Wahyuni Erna Dwi , Sudarmaji Wikan Purwihantoro , Proboningsih Jujuk , Mosteiro-Diaz María Pilar
Published: July 2024

During the COVID-19 pandemic which is a non-natural disaster, the ARDS cases (Acute Respiratory Disease Syndrome) rocketed. Despite the advantages of prone positioning for ARDS care, ICU staff seldom use it due to the unavailability of positioning tools, making it a challenging task for nurses. This study aims to investigate nurses' experiences with manual prone positioning and propose ICU-friendly prone position tools. This research method used a qualitative phenomenology theory study to 15 ICU nurses who were experienced in prone positioning at least 10 times to intubated patients and had complaints about the intervention. The experience was gathered using structured questions and recorded. The data was analyzed following Colaizzi’s thematic method, and all the emerged themes were collected and reported. The research results show that fifteen interviewed nurses noted that prone positioning is physically demanding and requires a coordinated team with a minimum of three staffs, 2 handles patient positioning, 1 leader securing the intubation tube. Before starting, the team assesses the difficulty level. Recommended tools include a slide sheet with handles, a modified Vollman prone positioner, and a crane-like prone harness. The conclusion is nurses find tools highly beneficial for prone positioning but will improvise with available resources like underpads as a ring-shaped pillow if tools are unavailable.
A Preliminary Report on the Role of Lipoxin A4 in Reinstating the Blood-Brain Barrier Integrity in a Rodent Model of Acute Inflammation with Impaired Cerebrovasculature
Authors: Patel Minjal ,   Rowan University, Varshney Shruti , Nethikunta Ananya , Godsey George G. , Kosciuk Mary C. , Rodriguez Ana , Spur Bernd , Yin Kingsley , Swanson Randel L. , Venkataraman Venkat , Nagele Robert G. , Acharya Nimish
Published: July 2024

Background: The blood-brain barrier (BBB) is responsible for maintaining brain homeostasis and ultimately proper neuronal function. Disruption of the BBB, leading to increased BBB permeability, has been reported in several neurodegenerative diseases, including Alzheimer’s disease (AD) and traumatic brain injury (TBI). Lipoxins (LXs) are a class of arachidonate-derived eicosanoids, which are a class of specialized pro-resolving lipid mediators (SPMs). SPMs are known to inhibit immune response through inhibition of cellular infiltration, downregulation of pro-inflammatory mediators and upregulation of anti-inflammatory mediators. Hence, LXs are recognized as “breaking signals” in the inflammatory process. One form of LXs, Lipoxin A4 (LXA4), has been found to decreased production of proinflammatory mediators, inhibit neutrophils chemotaxis and infiltration to the site of injury, and promote the phagocytic clearance of debris by macrophages. Therefore, LXA4 serves a critical role in resolution of inflammatory process by regulating the activation of monocytes and modulating the generation of reactive oxygen species (ROS). Hypothesis: LXA4 treatment reinstates the BBB integrity in a rodent model of acute BBB breakdown and inflammation. Methods: Nine-month-old female Sprague Dawley rats were given an intravenous (IV) injection of 15 mg/kg lipopolysaccharide (LPS) through the tail for inducing acute inflammation and BBB breach. After three hours, the rats were injected with 9 µg/kg LXA4 or Saline (Vehicle control). Four treatment groups were thus developed: LPS only, LPS/LXA4, LXA4 only, and Saline only. Animals were euthanized at 24 hours of LPS treatment and brain samples were processed for paraffin-embedded sections and immunohistochemistry. Sections comprising of hippocampus and cortical regions were selected for detection of impaired BBB as demonstrated by the extravasation of immunoglobulin G (IgG) and IBA1 (microgliosis marker). The area of the cerebral cortex and number of cortical blood vessels presenting with IgG extravasation were estimated and compared between treatment groups. Similarly, IBA1 immunoreactivity was quantified using Color Deconvolution V9 tool of Aperio ImageScope (Leica BIOSYSTEMS). Results: LXA4 treatment following LPS injection demonstrated decrease in the extent of IgG leak compared to LPS only group. Likewise, we observed significant decrease in microgliosis in LPS-LXA4 group compared to LPS only. Conclusion: These preliminary results demonstrate potential beneficial effects of LXA4 in reinstating BBB integrity and reducing neuroinflammation in rat model of acute BBB breach and inflammation.
A Case of HHV-6 Viral Meningitis
Authors: Rattu Mohammad A. , Tamaska Wayne
Published: July 2024

Meningitis is the inflammation of the meninges and associated with abnormal cell count in the cerebrospinal fluid (CSF). The lack of bacterial growth in cultures, most commonly referred to as aseptic meningitis, is frequently caused by viruses [2]. Viruses have become more common as the prevalence of bacterial meningitis has decreased secondary to vaccination use, with viral meningitis being the most common form among countries. Viral meningitis will present with fever, headache, photophobia, neck stiffness and nausea and vomiting. Younger children however may not show any signs of meningeal irritation. Viral meningitis is usually self-limiting and with good prognosis; however, appropriate evaluation is critical. Enteroviruses such as Coxsackie or Echovirus are the most common cause of viral meningitis across all age groups and parechoviruses are common among children. Herpesviruses leading to meningitis include herpes simplex virus (HSV) 1 and 2, varicella-zoster virus (VZV), cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6. Additional causes include adenovirus, lymphocytic choriomeningitis virus (LCMV), influenza, parainfluenza, and mumps. Arboviruses that can cause viral meningitis include West Nile virus (WNV), Zika, chikungunya, dengue, LaCross, Saint Louis encephalitis, Powassan, and eastern equine encephalitis virus.
Evaluation of psychosocial risks affecting academician using the sine trigonometric pythagorean fuzzy (ST-PFN) DEMATEL method
Authors: Tepe Serap , Çabuk Ahmet , Eti Serkan , Mertoğlu Bülent
Published: July 2024

BACKGROUND: In the realm of academia, psychosocial risk factors play a pivotal role, exerting considerable influence on the well-being and performance of scholars. Factors such as excessive workloads, unrelenting performance expectations, time constraints, and competitive atmospheres can detrimentally affect their health and overall quality of life. Moreover, issues like social isolation, work-life imbalance, and academic anxiety further compound these challenges, impeding academic progress and success. OBJECTIVE: Thus, it is imperative to identify, mitigate, and manage psychosocial risk factors effectively to foster a conducive academic environment conducive to productivity and achievement. METHODS: This study employs a novel approach, integrating expert opinions and utilizing sine trigonometry Pythagorean fuzzy numbers to ascertain the degrees of importance and rank psychosocial risk factors through the DEMATEL method. This methodology presents a unique contribution to existing literature, offering fresh insights into this critical area of study. RESULTS: Evaluation of 25 factors reveals burnout, job dissatisfaction, precarious working conditions, lack of trust, unfair treatment, job insecurity, and limited developmental opportunities as primary concerns, underscoring the multifaceted nature of these challenges. CONCLUSIONS: In the occupational sphere, active participation from all stakeholders in addressing psychosocial risks is paramount for effective problem resolution. It is incumbent upon parties involved to discharge their duties, foster collaboration, enhance working conditions, ensure equity, and facilitate avenues for professional growth. Each identified risk factor addressed and preempted translates into a tangible reduction in workplace accidents and occupational ailments, underscoring the tangible benefits of proactive risk management.
Ethical considerations in telehealth and artificial intelligence for work related musculoskeletal disorders: A scoping review
Authors: Karaibrahimoglu Adnan , İnce Fuat , Hassanzadeh Gholamreza , Alizadeh Ali , Bagheri Kian , Yucel Irem , Shariat Ardalan
Published: July 2024

BACKGROUND: Artificial Intelligence (AI) refers to the simulation of human intelligence in machines that are programmed to perform tasks that typically require human intelligence. The integration of AI and telehealth applications in healthcare raises ethical concerns such as bias, transparency, data privacy, and accountability for errors. Several studies have assessed this topic, particularly with regard to musculoskeletal disorders, which will be the focus of this manuscript. OBJECTIVE: We will examine key ethical concepts including informed consent, data protection, confidentiality, physician malpractice, liability, and telemedicine regulations. METHODS: Ethical issues pertaining to the topic were explored through a review paper. The primary objective of this scoping review was to map and synthesize the existing literature concerning ethical considerations in telehealth and AI for work-related musculoskeletal disorders. RESULTS: Research demonstrates that medication effectiveness, patient and physician satisfaction, and accessibility costs are higher with telemedicine and AI methods compared to in-person approaches, particularly for work-related musculoskeletal disorders. Therefore, addressing ethical issues, including patient data privacy and security, is crucial in this field. By considering these factors, the adoption of emerging AI and telemedicine applications, especially for work-related musculoskeletal disorders, is likely to increase. CONCLUSION: AI and telemedicine offer significant advantages, particularly in addressing work-related musculoskeletal disorders. However, ethical and legal issues surrounding their practice require standardized rules to ensure equitable access, quality care, sustainable costs, professional liability, patient privacy, data protection, and confidentiality. Further practical research studies are needed to address these considerations more effectively.
Energy-efficient solar heat supply system based on hybrid photovoltaic collector
Authors: Mysak Stepan , Shapoval Stepan , Matiko Halyna
Published: July 2024

Following the commitments made under the Paris Climate Agreement, the scientific community has initiated a strategic increase in the share of renewable energy sources while gradually reducing dependence on traditional carbon fuels. Priority is given to the acceleration of the development of the photovoltaic industry, which has shown a constant increase in capacity over the past decades. According to the energy and climate strategies of the European Union, a significant increase in the amount of energy generation due to solar sources is planned. Therefore, the article is devoted to the development of a solar heat supply system based on a hybrid thermal photovoltaic solar collector with an improved design and analysis of the main characteristics of its operation using computer modeling. The authors have developed a 3D computer model of the proposed hybrid system with a solar collector by using SolidWorks software. The change in the temperature of the heat carrier in the hybrid thermal photovoltaic solar collector under constant solar radiation was analyzed. The temperature change of the coolant in the thermal accumulator of the system was also investigated. The results of the simulation of thermal processes revealed the key regularities of the temperature increase during the computer experiment, both in the hybrid thermal photovoltaic solar collector and in the thermal accumulator. The change in the instantaneous specific heat capacity of the developed solar collector was analyzed, and its average efficiency was estimated. The trends of changes in the thermal efficiency of the developed heat supply system during the computer experiment were determined. The novelty of the study is that the design of the hybrid thermophotoelectric solar collector has been improved, its 3D computer model has been developed, and the main thermal characteristics of the developed heat supply system with constant solar radiation have been obtained, which will contribute to the development of calculation methods for such heat supply systems with hybrid solar collectors in the future.
Implementasi Algoritma Advanced Encryption Standart - 128 Berbasis Dekstop pada Teks dan Dokumen
Authors: Malik Syafril , Saifudin Aries
Published: July 2024

Mengingat pentingnya peranan informasi dalam setiap kegiatan dan proses komunikasi mengakibatkan adanya gangguan serta ancaman terhadap keamanan informasi yang bersifat rahasia dapat dimanipulasi oleh orang lain yang tidak berhak. Dalam penelitian ini akan menerapkan teknik kriptografi menggunakan metode AES (advance encryption standart) dalam sistem keamanan dokumen, untuk meminimalisir ancaman dan gangguan pada keamanan pesan dan informasi serta agar tidak dapat dilihat dan dicuri oleh pihak lain yang tidak berkepentingan. Berdasarkan implementasi dan pengujian yang dicapai di penelitan ini, penerapan kriptografi dan dalam sistem keamanan file terbukti dapat digunakan untuk meningkatkan keamanan dan terbukti dapat menjaga kerahasiannya agar tidak dapat dilihat maupun dibaca oleh orang lain yang tidak berkepentingan.