bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut
Authors: Nimmo Jacqui T. , Smith Harry , Wang Chang Yi , Teeling Jessica L. , Nicoll James A. R. , Verma Ajay , Dodart Jean-Cosme , Liu Zhi , Lin Feng , Carare Roxana O.
Published: November 2021

Alpha synuclein has a key role in the pathogenesis of Parkinson’s disease (PD), Dementia with Lewy Bodies (LBD) and Multiple System Atrophy (MSA). Immunotherapies aiming at neutralising toxic αSyn species are being investigated in the clinic as potential disease modifying therapies for PD and other synucleinopathies. In this study, the effects of active immunisation against αSyn with the UB-312 vaccine were investigated in the Thy1SNCA/15 mouse model of PD. Young transgenic and wild-type mice received an immunisation regimen over a period of 6 weeks, then observed for an additional 9 weeks. Behavioural assessment was conducted before immunisation and at 15 weeks after the first dose. UB-312 immunisation prevented the development of motor impairment in the wire test and challenging beam test, which was associated with reduced levels of αSyn oligomers in the cerebral cortex, hippocampus and striatum of Thy1SNCA/15 mice. UB-312 immunotherapy resulted in a significant reduction of theαSyn load in the colon, accompanied by a reduction in enteric glial cell reactivity in the colonic ganglia. Our results demonstrate that immunisation with UB-312 prevents functional deficits and both central and peripheral pathology in Thy1SNCA/15 mice.
Impact of chronic stress exposure on cognitive performance incorporating the active and healthy aging (AHA) concept within the cross-sectional Bern Cohort Study 2014 (BeCS-14)
Authors: Arifi Deborah , Bitterlich Norman , von Wolff Michael , Poethig Dagmar , Stute Petra
Published: November 2021

Purpose

This study aims to verify that the mental-cognitive domain of the validated generic bio-functional status (BFS)/bio-functional age (BFA) assessment tool, incorporating the concept of Active and Healthy Ageing (AHA), reflects cognitive performance. In addition, the effects of chronic stress exposure on the mental-cognitive BFS/BFA should be investigated.

Methods

The study was carried out as a monocenter, cross-sectional, observational, non-interventional trial (Bern Cohort Study 2014, BeCS-14) with the participation of 147 non-pediatric, non-geriatric subjects. All participants followed a standardized battery of biopsychosocial assessments consisting of BFS/BFA, a validated cognitive performance test battery (Inventar zur Gedächtnisdiagnostik; IGD) and a validated questionnaire for the assessment of chronic stress (Trier Inventory for the assessment of Chronic Stress; TICS), respectively.

Results

Mean cognitive performance was average and higher in younger or better educated individuals. The BFA of the participants was 7.8 ± 7.8 year-equivalents below their chronological age. The mental-cognitive BFS/BFA assessment correlated well with the validated questionnaire for cognition assessment, the IGD. Further, three TICS subdomains (work overload (r =  − 0.246, p = 0.003), work discontent (r =  − 0.299, p = 0.006) and pressure to succeed (r =  − 0.274, p < 0.001)), reflecting mainly work-related stress, showed a significant negative correlation with the mental-cognitive BFS/BFA.

Conclusions

Our study shows that the BFS/BFA assessment tool follows European Innovation Partnership on Active and Healthy Ageing (EIP-AHA) requirements. Further, we could demonstrate that higher levels of chronic work-related stress may be associated with poorer mental-cognitive performance and a pro-aging state indicating that cognitive impairments can be reduced by stress management interventions.
Prevalence and patterns of traumatic dental injuries in primary teeth: a 3-year retrospective overview study in Vienna
Authors: Lembacher Sophie , Schneider Steffen , Lettner Steffen , Bekes Katrin
Published: November 2021

Objectives

The aim of this study was to retrospectively identify the prevalence, patterns, and accident types of traumatic dental injuries (TDIs) in children with primary teeth in Vienna, Austria.

Material and methods

The investigation was conducted as a retrospective overview study including all children with TDIs in primary teeth at the University Dental Clinic of Vienna (Austria) between 2014 and 2016. Dental records including age, gender, location of trauma, type of trauma, cause of TDI, and location of traumatic incident were obtained. Furthermore, the time of presentation and the time span between TDI and initial treatment were evaluated.

Results

The sample comprised TDIs in 243 patients with 403 primary teeth. In a ratio of 1:1.45, boys were significantly more involved than girls. Upper central and lateral incisors were most frequently affected (n = 371, 92.1%). Dislocations were the most common type of injury (n = 298, 74%) with subluxations being the most prevalent form (n = 85, 28.5%). In 23% (n = 92), fractures were observed. The majority of traumatic incidents occurred at home (88.5%).

Conclusion

The injury characteristics are comparable to what has previously been reported in other studies in pediatric populations.

Clinical relevance

TDIs are a prevalent event in children worldwide and incisors are the most affected teeth in the primary dentition. Thus, dental practitioners should be able to handle these injuries.
Clinical and histological evaluation of a dual sequential application of fractional 10,600 nm and 1570 nm lasers, compared to single applications in a porcine model
Authors: Snast Igor , Lapidoth Moshe , Levi Assi
Published: November 2021

The sequential application of fractional ablative/10,600 nm/CO2 followed by 1570 nm non-ablative laser treatment might produce better results than applying either laser treatment alone. However, histological data regarding the safety of this combination is lacking. This study aimed to assess and compare clinical effects, histological tissue damage, and wound healing after monochromatic and sequential fractional laser treatments. In this prospective porcine model study, three adult female pigs were each irradiated using three different wavelengths: (a) monochromatic fractional ablative CO2 laser; (b) monochromatic fractional non-ablative 1570 nm laser; (c) sequential fractional 10,600 nm/CO2 followed by 1570 nm laser treatment. There were six power levels in the monochromatic 1570 nm laser, five in the 10,600 nm/CO2, and five in the sequential treatment. The immediate skin reaction (ISR), crusting and adverse effects, was evaluated across different time points throughout the healing process. Wound biopsies were taken at immediately after (0) and at 3, 7, and 14 days after irradiation. Depth and width of craters, and width of coagulation zone were measured and compared. Similar ISR and crusting score values were obtained following the monochromatic and sequential irradiation in a similar dose–response manner. During 14 days of follow-up, the skin looked intact and non-infected with no signs of necrosis. The mean depth and width of craters were comparable only at the maximal energy level (240 mJ) of CO2 laser, with the coagulation size greater after the sequential treatment. In histology, a similar wound healing was evident. On day 3, crusts were observed above all lesions as was epithelial regeneration. The sequential irradiation with 10,600 nm/CO2 and 1570 nm lasers did not pose any additional risk compared to the risk of each laser alone.
Interdisciplinary insights into the link between gut microbiome and gastric carcinogenesis—what is currently known?
Authors: Kaźmierczak-Siedlecka Karolina , Daca Agnieszka , Roviello Giandomenico , Catalano Martina , Połom Karol
Published: November 2021

Currently, gastric cancer is one of the leading death-related cancer globally. The etiopathogenesis of gastric cancer is multifactorial and includes among others dysbiotic alterations of gastric microbiota. Molecular techniques revealed that stomach is not a sterile organ and it is resides with ecosystem of microbes. Due to the fact that the role ofHelicobacter pyloriinfection in development of gastric cancer is established and well-studied, this paper is mainly focused on the role of other bacterial as well as viral and fungal gut microbiota imbalance in gastric carcinogenesis. Notably, not only the composition of gastric microbiota may play an important role in development of gastric cancer, but also its activity. Microbial metabolites, such as short-chain fatty acids, polyamines, N-nitroso compounds, and lactate, may significantly affect gastric carcinogenesis. Therefore, this paper discussed aforementioned aspects with the interdisciplinary insights (regarding also immunological point of view) into the association between gut microbiome and gastric carcinogenesis based on up-to-date studies.
Two-phase SPH modelling of a real debris avalanche and analysis of its impact on bottom drainage screens
Authors: Tayyebi Saeid M. , Pastor Manuel , Stickle Miguel M. , Yagüe Ángel , Manzanal Diego , Molinos Miguel , Navas Pedro
Published: November 2021

Rapid flow-like landslides, particularly debris flows and debris avalanches, cause significant economic damage and many victims worldwide every year. They are usually extremely fast with the capability of travelling long distances in short times, sweeping away everything in their path. The principal objective of this paper is to test the ability of the ‘GeoFlow-SPH’ two-phase model developed by the authors, to reproduce the complex behaviour of natural debris avalanches where pore-water pressure evolution plays a key role. To reach this goal, the model is applied to reproduce the complex dynamic behaviour observed in Johnsons Landing debris avalanche including the observed bifurcation caused by the flowing out of part of the moving mass from the mid-channel. Initial thickness deposit trim-line, distribution of deposit volume, and the average velocities were provided for this real case, making it an appropriate case to validate the developed model. The paper also contributes to evaluate the SPH-FD model’s potentialities to simulate the structural countermeasure, like bottom drainage screens, used to reduce the impact of debris flows. The analysis of the results shows the adequacy of the proposed model to solve this complicated geophysical problem.
Key predictors of soil organic matter vulnerability to mineralization differ with depth at a continental scale
Authors: Weiglein Tyler L. , Strahm Brian D. , Bowman Maggie M. , Gallo Adrian C. , Hatten Jeff A. , Heckman Katherine A. , Matosziuk Lauren M. , Nave Lucas E. , Possinger Angela R. , SanClements Michael D. , Swanston Christopher W.
Published: November 2021

Soil organic matter (SOM) is the largest terrestrial pool of organic carbon, and potential carbon-climate feedbacks involving SOM decomposition could exacerbate anthropogenic climate change. However, our understanding of the controls on SOM mineralization is still incomplete, and as such, our ability to predict carbon-climate feedbacks is limited. To improve our understanding of controls on SOM decomposition, A and upper B horizon soil samples from 26 National Ecological Observatory Network (NEON) sites spanning the conterminous U.S. were incubated for 52 weeks under conditions representing site-specific mean summer temperature and sample-specific field capacity (−33 kPa) water potential. Cumulative carbon dioxide respired was periodically measured and normalized by soil organic C content to calculate cumulative specific respiration (CSR), a metric of SOM vulnerability to mineralization. The Boruta algorithm, a feature selection algorithm, was used to select important predictors of CSR from 159 variables. A diverse suite of predictors was selected (12 for A horizons, 7 for B horizons) with predictors falling into three categories corresponding to SOM chemistry, reactive Fe and Al phases, and site moisture availability. The relationship between SOM chemistry predictors and CSR was complex, while sites that had greater concentrations of reactive Fe and Al phases or were wetter had lower CSR. Only three predictors were selected for both horizon types, suggesting dominant controls on SOM decomposition differ by horizon. Our findings contribute to the emerging consensus that a broad array of controls regulates SOM decomposition at large scales and highlight the need to consider changing controls with depth.
Involuntary Youth Transport (IYT) to Treatment Programs: Best Practices, Research, Ethics, and Future Directions
Authors: Gass Michael , Hardy Clinton , Norton Christine , Priest Simon
Published: November 2021

Involuntary youth transport (IYT) is a controversial practice used to admit adolescents into residential care. Critics point out that IYT is in need of regulation and is best used as a last resort. This article examines the risks and benefits of IYT, especially the longterm effects on the client, in order to ensure that all facets of a client’s treatment are trauma-informed and guided by research-based practices and ethical principles. Practices that re-traumatize youth need to be replaced with informed practices that facilitate positive outcomes. This article utilizes an ethical decision-making framework developed for behavioral health professionals to assess and improve the ethical use of IYT. Based on this ethical framework, a more effective and collaborative model is presented that results in less restrictive approaches, greater levels of willingness by the adolescent to enter treatment, and trauma-informed management of difficult emotional or physical behaviors. This model also guides professionals and caregivers on how to proceed when IYT services are deemed necessary. The article presents past research and addresses ethical guidelines and best practices for IYT. Steps for practitioners and future directions are discussed.
Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks
Authors: Gospodinova Katerina O. , Olsen Ditte , Kaas Mathias , Anderson Susan M. , Phillips Jonathan , Walker Rosie M. , Bermingham Mairead L. , Payne Abigail L. , Giannopoulos Panagiotis , Pandya Divya , Spires-Jones Tara L. , Abbott Catherine M. , Porteous David J. , Glerup Simon , Evans Kathryn L.
Published: November 2021

SORCS2 is one of five proteins that constitute the Vps10p-domain receptor family. Members of this family play important roles in cellular processes linked to neuronal survival, differentiation and function. Genetic and functional studies implicate SORCS2 in cognitive function, as well as in neurodegenerative and psychiatric disorders. DNA damage and DNA repair deficits are linked to ageing and neurodegeneration, and transient neuronal DNA double-strand breaks (DSBs) also occur as a result of neuronal activity. Here, we report a novel role for SORCS2 in DSB formation. We show that SorCS2 loss is associated with elevated DSB levels in the mouse dentate gyrus and that knocking out SORCS2 in a human neuronal cell line increased Topoisomerase IIβ-dependent DSB formation and reduced neuronal viability. Neuronal stimulation had no impact on levels of DNA breaks in vitro, suggesting that the observed differences may not be the result of aberrant neuronal activity in these cells. Our findings are consistent with studies linking the VPS10 receptors and DNA damage to neurodegenerative conditions.
An Agent that Facilitates Crowd Discussion
Authors: Ito Takayuki , Hadfi Rafik , Suzuki Shota
Published: November 2021

Online discussion platforms are perceived as the next-generation method of citizen involvement. Such platforms can collect, integrate, and synthesize opinions to achieve social good. Crowd-scale platforms are being developed and deployed in social experiments that involve citizens and local governments. In such platforms, human facilitation is often used to preserve the quality of the discussions. Human facilitators often face difficulties when the discussions grow in size. In this paper, we present “D-agree,” a crowd-scale discussion support system based on an automated facilitation agent. The agent extracts discussion structures from online discussions, analyzes them, and posts facilitation messages. We conducted small- and large-scale social experiments in Japan to assess the social impact of the platform. The results showcase the success of our automated facilitation agents in gathering valuable opinions from citizens. In addition, our experiments highlight the effect of an automated facilitation agent on online discussions. In particular, we find that combining the agent facilitator with human facilitators leads to higher user satisfaction.
Can Substitutes Reduce Future Demand for Wildlife Products: A Case Study of China’s Millennial Generation
Authors: Rock Katherine I. , MacMillan Douglas C.
Published: November 2021

China is one of the world’s leading consumer markets for wildlife products, yet there is little understanding of how demand will change in the future. In this study, we investigate the consumptive habits and attitudes of the millennial ‘Juilinghou’ demographic – a subset of society in China with the potential to substantially influence future demand for wildlife products. We surveyed 350 Chinese university students across Harbin and Beijing, China, and found that the intended future consumption of wildlife products was relatively low in this population but with a strong orientation towards wildlife products with medicinal properties. Seventy percent of those respondents who had used and/or intended to use wildlife products were willing to try substitutes, but this was heavily dependent on their price (cheaper) and quality. The insights gained through this survey are intended to meaningfully inform future initiatives to introduce sustainable substitutability into wildlife markets to alert future wildlife product consumers to alternative choices.
Do Sports Programs Prevent Crime and Reduce Reoffending? A Systematic Review and Meta-Analysis on the Effectiveness of Sports Programs
Authors: Jugl Irina , Bender Doris , Lösel Friedrich
Published: November 2021

Objectives

Sports programs are widely implemented as measures of crime prevention. In contrast to their popularity, there is little systematic knowledge about their effectiveness. This systematic review and meta-analysis have been carried out to fill this gap. In a systematic review, we gathered data on evaluated prevention programs specifically designed to prevent crime and delinquency. We then conducted a meta-analytic integration with studies using at least roughly equivalent control groups for the program evaluation.

Method

To retrieve relevant literature, we conducted a comprehensive international literature search until June 2021 drawing on scientific databases. We also applied snow-balling searches and contacted practitioners in the field. Studies were eligible if they evaluated sports programs designed to prevent delinquency on primary, secondary, and/or tertiary level. We focused on crime-related outcomes and potentially underlying psycho-social factors. We made no restrictions regarding characteristics of the participants or other aspects such as duration of the program.

Results

24 studies were eligible for our systematic review, from which only thirteen were included into our meta-analytic integration. We found a moderate effect of participation in sports programs on crime-related outcomes (d = 0.36,p < .001). Participants showed a significant decrease in outcomes such as aggressiveness or anti-social behavior. We also analyzed psychological outcomes such as self-esteem or mental well-being, which also significantly improved when participating in sports programs (d = 0.87,p < ..05).

Conclusions

Sports programs seem to be an effective measure of crime prevention. However, future research needs more sound evaluation designs and moderator analyses to better understand the functioning and improve the implementation of sports programs.
The Combined Contribution of Fear and Perceived Danger of COVID-19 and Metacognitions to Anxiety Levels during the COVID-19 Pandemic
Authors: Aydın Orkun , Balıkçı Kuzeymen , Arslan Yasin , Ünal-Aydın Pınar , Müezzin Ece , Spada Marcantonio M.
Published: November 2021

Despite a wide base of research suggesting a major role for dysfunctional metacognitions in contributing to anxiety, their role in explaining psychological distress in the context of the COVID-19 pandemic remains unclear. In this study we investigated whether metacognitions would predict anxiety, while controlling for fear and perceived danger of COVID-19. A total of 862 individuals were included in this study. Participants completed sociodemographic questions, emotional state questions relating to COVID-19, the Metacognitions Questionnaire‐30, and the Generalized Anxiety Disorder-7. Results showed that both negative beliefs about thoughts concerning uncontrollability and danger, and cognitive self-consciousness were significant predictors of anxiety beyond the fear and perceived danger of COVID-19. Future studies involving clinical populations are needed to investigate the longer-term impact of metacognitions in the maintenance and exacerbation of anxiety associated with the fear and perceived danger of COVID-19.
Detection of agglomerate fog based on a shallow convolutional neural network
Authors: Li Linlin , Yang Bo , Chen Shaohui
Published: November 2021

As a kind of frequent bad weather, Agglomerate fog is a serious danger to people's safe driving, especially on the highway. Therefore, the research on the detection of fog is of great practical significance to ensure the safety of pedestrians. This paper proposes a shallow convolutional neural network for agglomerate fog detection in images, including the framework of the network and the detailed design of each component. Firstly, the image is divided into several sub-images; and then a shallow convolutional neural network is constructed and employed to identify the existence of fog for each of the sub-area images; lastly, the decision results of each sub-area images were integrated to determine whether the whole image contained agglomerate fog. A large quantity of simulation data and real data were used to test the performance of the proposed method, the experimental results show that the presented method can achieve more than 90% detection accuracy, which demonstrated that the advantage of the proposed method comparing with several existed methods.
ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity
Authors: Brownstein Alexandra J. , Veliova Michaela , Acin-Perez Rebeca , Liesa Marc , Shirihai Orian S.
Published: November 2021

Obesity results from an imbalance in energy homeostasis, whereby excessive energy intake exceeds caloric expenditure. Energy can be dissipated out of an organism by producing heat (thermogenesis), explaining the long-standing interest in exploiting thermogenic processes to counteract obesity. Mitochondrial uncoupling is a process that expends energy by oxidizing nutrients to produce heat, instead of ATP synthesis. Energy can also be dissipated through mechanisms that do not involve mitochondrial uncoupling. Such mechanisms include futile cycles described as metabolic reactions that consume ATP to produce a product from a substrate but then converting the product back into the original substrate, releasing the energy as heat. Energy dissipation driven by cellular ATP demand can be regulated by adjusting the speed and number of futile cycles. Energy consuming futile cycles that are reviewed here are lipolysis/fatty acid re-esterification cycle, creatine/phosphocreatine cycle, and the SERCA-mediated calcium import and export cycle. Their reliance on ATP emphasizes that mitochondrial oxidative function coupled to ATP synthesis, and not just uncoupling, can play a role in thermogenic energy dissipation. Here, we review ATP consuming futile cycles, the evidence for their function in humans, and their potential employment as a strategy to dissipate energy and counteract obesity.
Diet and dog characteristics affect major and trace elements in hair and blood of healthy dogs
Authors: Rosendahl Sarah , Anturaniemi Johanna , Vuori Kristiina A. , Moore Robin , Hemida Manal , Hielm-Björkman Anna
Published: November 2021

Obtaining correct amounts of essential elements, and avoiding toxic metals are key factors in dog health. Through analyzing major and trace elements in hair and blood of 50 healthy companion dogs using ICP-MS, we study their associations with dog characteristics and diet, hypothesizing that eating the same diet long-term results in strong correlations between hair and blood element concentrations, and that dog characteristics and diet affect element status. The correlation between hair and blood was significant for Hg (R = 0.601, p = 0.000) and Pb (R = 0.384, p = 0.010). The following associations were significant (p < 0.05): Dark hair had higher Ca and Mg compared to light hair. Females had higher hair Zn, blood Mn, and blood As compared to males. Blood Mn and Se increased, while blood Pb decreased with age. Raw diet fed dogs had higher hair Zn and Se compared to dry or mixed diet fed dogs, and lower blood Mn compared to dry diet fed dogs. Dry and mixed diet fed dogs had higher blood Cd compared to raw diet fed dogs. Mixed diet fed dogs had higher hair Ca and Mg compared to raw or dry diet fed dogs, and higher hair Pb compared to dry diet fed dogs. Wild game consumption was associated with higher blood Pb, and rice consumption with higher blood As. In conclusion, hair provides an alternative for assessing Hg and Pb exposure, and major and trace elements status is affected by hair color, sex, age, and diet.
Multiscale Modelling of De Novo Anaerobic Granulation
Authors: Tenore A. , Russo F. , Mattei M. R. , D’Acunto B. , Collins G. , Frunzo L.
Published: November 2021

A multiscale mathematical model is presented to describe de novo granulation, and the evolution of multispecies granular biofilms, in a continuously fed bioreactor. The granule is modelled as a spherical free boundary domain with radial symmetry. The equation governing the free boundary is derived from global mass balance considerations and takes into account the growth of sessile biomass as well as exchange fluxes with the bulk liquid. Starting from a vanishing initial value, the expansion of the free boundary is initiated by the attachment process, which depends on the microbial species concentrations within the bulk liquid and their specific attachment velocity. Nonlinear hyperbolic PDEs model the growth of the sessile microbial species, while quasi-linear parabolic PDEs govern the dynamics of substrates and invading species within the granular biofilm. Nonlinear ODEs govern the evolution of soluble substrates and planktonic biomass within the bulk liquid. The model is applied to an anaerobic, granular-based bioreactor system, and solved numerically to test its qualitative behaviour and explore the main aspects of de novo anaerobic granulation: ecology, biomass distribution, relative abundance, dimensional evolution of the granules and soluble substrates, and planktonic biomass dynamics within the bioreactor. The numerical results confirm that the model accurately describes the ecology and the concentrically layered structure of anaerobic granules observed experimentally, and that it can predict the effects on the process of significant factors, such as influent wastewater composition; granulation properties of planktonic biomass; biomass density; detachment intensity; and number of granules.
Structured reporting of computed tomography in the staging of colon cancer: a Delphi consensus proposal
Authors: Granata Vincenza , Faggioni Lorenzo , Grassi Roberta , Fusco Roberta , Reginelli Alfonso , Rega Daniela , Maggialetti Nicola , Buccicardi Duccio , Frittoli Barbara , Rengo Marco , Bortolotto Chandra , Prost Roberto , Lacasella Giorgia Viola , Montella Marco , Ciaghi Eleonora , Bellifemine Francesco , De Muzio Federica , Grazzini Giulia , De Filippo Massimo , Cappabianca Salvatore , Laghi Andrea , Grassi Roberto , Brunese Luca , Neri Emanuele , Miele Vittorio , Coppola Francesca
Published: November 2021

Background

Structured reporting (SR) in radiology is becoming increasingly necessary and has been recognized recently by major scientific societies. This study aims to build structured CT-based reports in colon cancer during the staging phase in order to improve communication between the radiologist, members of multidisciplinary teams and patients.

Materials and methods

A panel of expert radiologists, members of the Italian Society of Medical and Interventional Radiology, was established. A modified Delphi process was used to develop the SR and to assess a level of agreement for all report sections. Cronbach’s alpha (Cα) correlation coefficient was used to assess internal consistency for each section and to measure quality analysis according to the average inter-item correlation.

Results

The final SR version was built by including n = 18 items in the “Patient Clinical Data” section, n = 7 items in the “Clinical Evaluation” section, n = 9 items in the “Imaging Protocol” section and n = 29 items in the “Report” section. Overall, 63 items were included in the final version of the SR. Both in the first and second round, all sections received a higher than good rating: a mean value of 4.6 and range 3.6–4.9 in the first round; a mean value of 5.0 and range 4.9–5 in the second round. In the first round, Cronbach’s alpha (Cα) correlation coefficient was a questionable 0.61. In the first round, the overall mean score of the experts and the sum of scores for the structured report were 4.6 (range 1–5) and 1111 (mean value 74.07, STD 4.85), respectively. In the second round, Cronbach’s alpha (Cα) correlation coefficient was an acceptable 0.70. In the second round, the overall mean score of the experts and the sum of score for structured report were 4.9 (range 4–5) and 1108 (mean value 79.14, STD 1.83), respectively. The overall mean score obtained by the experts in the second round was higher than the overall mean score of the first round, with a lower standard deviation value to underline greater agreement among the experts for the structured report reached in this round.

Conclusions

A wide implementation of SR is of critical importance in order to offer referring physicians and patients optimum quality of service and to provide researchers with the best quality data in the context of big data exploitation of available clinical data. Implementation is a complex procedure, requiring mature technology to successfully address the multiple challenges of user-friendliness, organization and interoperability.
Motor Reaction Times as an Embedded Measure of Performance Validity: a Study with a Sample of Austrian Early Retirement Claimants
Authors: Czornik Manuel , Seidl Doris , Tavakoli Sophie , Merten Thomas , Lehrner Johann
Published: November 2021

Among embedded measures of performance validity, reaction time parameters appear to be less common. However, their potential may be underestimated. In the German-speaking countries, reaction time is often examined using the Alertness subtest of the Test of Attention Performance (TAP). Several previous studies have examined its suitability for validity assessment. The current study was conceived to examine a variety of reaction time parameters of the TAP Alertness subtest with a sample of 266 Austrian civil forensic patients. Classification results from the Word Memory Test (WMT) were used as an external indicator to distinguish between valid and invalid symptom presentations. Results demonstrated that the WMT fail group performed worse in reaction time as well as its intraindividual variation across trials when compared to the WMT pass group. Receiver operating characteristic analyses revealed areas under the curve of .775–.804. Logistic regression models indicated the parameter intraindividual variation of motor reaction time with warning sound as being the best predictor for invalid test performance. Suggested cut scores yielded a sensitivity of .62 and a specificity of .90, or .45 and .95, respectively, when the accepted false-positive rate was set lower. The results encourage the use of the Alertness subtest as an embedded measure of performance validity.
Hereditary cancer panel testing challenges and solutions for the latinx community: costs, access, and variants
Authors: Douglas Michael P. , Lin Grace A. , Trosman Julia R. , Phillips Kathryn A.
Published: November 2021

Hereditary breast and ovarian cancers (HBOCs) are common among the Latinx population, and risk testing is recommended using multi-gene hereditary cancer panels (HCPs). However, little is known about how payer reimbursement and out-of-pocket expenses impact provider ordering of HCP in the Latinx population. Our objective is to describe key challenges and possible solutions for HCP testing in the Latinx population. As part of a larger study, we conducted semi-structured interviews with key provider informants (genetic counselors, oncologist, nurse practitioner) from safety-net institutions in the San Francisco Bay Area. We used a deductive thematic analysis approach to summarize themes around challenges and possible solutions to facilitating HCP testing in Latinx patients. We found few financial barriers for HCP testing for the Latinx population due to laboratory patient assistance programs that cover testing at low or no cost to patients. However, we found potential challenges related to the sustainability of low-cost testing and out-of-pocket expenses for patients, access to cascade testing for family members, and pathogenic variants specific to Latinx. Providers questioned whether current laboratory payment programs that decrease barriers to testing are sustainable and suggested solutions for accessing cascade testing and ensuring variants specific to the Latinx population were included in testing. The use of laboratories with payment assistance programs reduces barriers to HCP testing among the US population; however, other barriers are present that may impact testing use in the Latinx population and must be addressed to ensure equitable access to HCP testing for this population.
Does the Intuition of Distinctness Result from Valid Reasoning? – Reply to Kammerer
Authors: Polcyn Karol
Published: November 2021

According to an influential physicalist view, the intuition of distinctness is a cognitive illusion in the sense that it results from fallacious reasoning: we erroneously infer that the referents of phenomenal and physical concepts are different, from the fact that there is a certain difference between our uses of those concepts. (Kammerer, Review of Philosophy and Psychology 10:649–667, 2019) has recently argued, however, that it is psychologically implausible that the intuition of distinctness results from a fallacy: the reasoning process leading to this intuition is, in several psychological respects, similar to valid reasoning and dissimilar to typical fallacies, which gives us a reason to think that this process is a case of valid reasoning. I argue that there are no psychological reasons to think that the process underlying the intuition of distinctness (or at least the crucial part of this process) is a case of valid reasoning. There is, in fact, only one crucial psychological respect in which this process resembles valid reasoning, and although the two processes are similar in one crucial respect, this does not rule out that the intuition of distinctness results from a fallacy, namely, the sort of fallacious reasoning that physicalists have in mind. Furthermore, since the process underlying the intuition of distinctness resembles typical fallacies in one crucial respect, there is a reason to think that the intuition of distinctness does result from a fallacy.
Bacteriological quality of household drinking water in North Gondar Zone, Ethiopia; a community-based cross-sectional study
Authors: Getachew Atalay , Tadie Alebachew , Chercos Daniel Haile , Guadu Tadesse , Alemayehu Marta , Gizaw Zemichael , G/Hiwot Mulat , G/Cherkos Teklay
Published: November 2021

Ethiopia is one of the developing countries where only 52% of its population have access to safe drinking water. To determine the level of faecal contamination in drinking water, the E. coli has been found to be the most specific indicator. The purpose of this study was to determine household bacteriological drinking water quality and its associated factors in rural North Gondar Zone Ethiopia. A community-based cross-sectional study was conducted in rural parts of North Gondar Zone from April to June, 2016. Water samples from water storage at household level were taken using standardized water sampling techniques to determine the level of faecal contamination. Face-to-face interview using structured questionnaires and checklist were used to identify the associated factors. A total of 736 households participated in this study. The prevalence of positive faecal coliform in the households is found to be 72.6% (95%C.I; 69.4–75.8). In multivariate analysis; occupational status [AOR; 0.35, 95%; CI (0.16,0.77)], income [(AOR);0.45, 95%; CI (0.3, 0.68)], type of solid waste disposal habit [AOR; 0.16, 95%; CI (0.36, 0.66)], source of water [AOR; 0.42, 95%; CI (0.28, 0.65)], shortage of water [AOR; 2.8, 95%; CI (1.88, 4)] were variables identified as predictors for faecal coliform contamination of water in the household. There is high level of faecal contamination of household drinking water in North Gondar Zone. Occupational status, income, solid waste disposal habit, sources of drinking water, and shortage of water were predictor for presence of faecal coliform contamination in household drinking water.
Assessment of the quality of the Densu river using multicriterial analysis and water quality index
Authors: Ofosu Samuel Anim , Adjei Kwaku A. , Odai Samuel Nii
Published: November 2021

The natural resources, especially water in the Densu river basin, play significant roles in the socio-economic development of Ghana. The purpose of this study was to analyse the water quality of the Densu river using water quality index (WQI) and multivariate techniques. In this study, physico-chemical and bacteriological parameters were measured from surface water samples taken from eight (8) sampling stations in the study area. water quality index and multivariate techniques such as hierarchical cluster analysis and principal component analysis were utilized in the analysis of surface water quality data. The results indicated that the average WQI of the Densu river for the two sampling periods was sixty-one (61) which is classified as Medium, based on the Solway WQI index. The pH levels of all the samples were within allowable limits of World Health Organization (WHO) guidelines. All the sampling stations for the two seasonal periods had bacteriological parameters higher than WHO guidelines, making the samples unsuitable for most domestic uses. The study revealed that six (6) principal components accounted for about 97% of the total variance of dataset and three (3) spatial clusters were classified. This research has provided the basis for applying both WQI and multivariate techniques in analysing and classifying water quality in a river basin.
Exploration of groundwater potential zones using analytical hierarchical process (AHP) approach in the Godavari river basin of Maharashtra in India
Authors: Rajesh J. , Pande Chaitanya B. , Kadam Sunil A. , Gorantiwar Sunil D. , Shinde Mukund G.
Published: November 2021

Total natural and groundwater resources play the most crucial role in developing ecological, biological and socioeconomic doings. Various parameters like land use, geology, elevation, slope, lineament, lineament density, drainage density and geomorphology affect the groundwater development of recharge and its accessibility. In this research, geographical information system (GIS), remote sensing, weighted overlay analysis and analytical hierarchy process (AHP) methods have been used for groundwater prospects mapping,  and identifying suitable solutions site for soil and water conservation structures. To calculate the weights were assigned to every layers component in the determination of affecting factors. The weighted overlay analysis (WOA) tool is applied to give the sub-parameter ratings based on the scientific literature. The final map of potential groundwater zone map has prepared using Arc GIS 10.1 software and AHP methods. About 49.71% of the areas fall under the 'good potential zone, 41.05% falls under the 'moderate potential zone', and 9.22% falls under the 'poor zone by using AHP technique. Groundwater potential zone map is depend on the weighted overlay analysis and analytical hierarchy process (AHP) methods. The highest GWP is located in the lower part of the basin due to the best surface runoff gathering, infiltration situations and subsurface storage volume. The present study procedure, methods and outcomes can be valuable to estimate the suitable groundwater zones parallel to improve the dry land area in the semi-arid and arid regions of India.
Endocrine disruptors in boiled drinking water carried in plastic containers: a pilot study in Thrissur, Kerala, India
Authors: Geetha T.
Published: November 2021

Boiled drinking water is carried by students to schools and colleges in plastic containers. However, the risk associated with drinking water stored in plastic containers is very real especially the question of leachates finding their way into the water stored in these containers. In this pilot study, we identified the most common plastic container used by students to carry water and the factors that govern their choice. Polyethylene terephthalate (PET) was identified as the most favored plastic used to carry water. PET bottles were then subject to treatments that mimic conditions representative of normal consumer usage. The water sample collected was tested for the presence of phthalates, antimony & titanium, and their content estimated by gas chromatography and atomic absorption spectra. Although phthalates and antimony leach into water from PET bottles their concentration was not high enough to pose a threat to human life. However, the trend of increasing antimony concentration with temperature and time is a cause of concern because of its role as endocrine disruptors. Prolonged and repeated use of PET bottles to carry water, especially warm water may lead to health problems in the community.
Development and optimization of sewage wastewater treatment program
Authors: Obidike Lawrence , Madigoe Ezekiel
Published: November 2021

In this study, a wastewater treatment program was developed and optimized for the treatment of sewage wastewater. Central composite face design (CCFD) and response surface methodology (RSM) were utilized to develop the experimental design and to establish the relationship between the independent variables (coagulant and flocculant dosage) and responses (turbidity and total dissolved solids removal). Statistical analysis showed that the developed response models were accurate. Optimal removal efficiencies of 93.3% and 23.2% for turbidity and TDS, respectively, were obtained under the optimal conditions for coagulant (120.9 ppm of U6750) and flocculant (125 ppm of Floc887) dosage. This showed that the developed treatment using the coagulant, U6750 and flocculant, Floc887 improved the physical characteristics of the wastewater.
Performance of machine learning methods in predicting water quality index based on irregular data set: application on Illizi region (Algerian southeast)
Authors: Kouadri Saber , Elbeltagi Ahmed , Islam Abu Reza Md. Towfiqul , Kateb Samir
Published: November 2021

Groundwater quality appraisal is one of the most crucial tasks to ensure safe drinking water sources. Concurrently, a water quality index (WQI) requires some water quality parameters. Conventionally, WQI computation consumes time and is often found with various errors during subindex calculation. To this end, 8 artificial intelligence algorithms, e.g., multilinear regression (MLR), random forest (RF), M5P tree (M5P), random subspace (RSS), additive regression (AR), artificial neural network (ANN), support vector regression (SVR), and locally weighted linear regression (LWLR), were employed to generate WQI prediction in Illizi region, southeast Algeria. Using the best subset regression, 12 different input combinations were developed and the strategy of work was based on two scenarios. The first scenario aims to reduce the time consumption in WQI computation, where all parameters were used as inputs. The second scenario intends to show the water quality variation in the critical cases when the necessary analyses are unavailable, whereas all inputs were reduced based on sensitivity analysis. The models were appraised using several statistical metrics including correlation coefficient (R), mean absolute error (MAE), root mean square error (RMSE), relative absolute error (RAE), and root relative square error (RRSE). The results reveal that TDS and TH are the key drivers influencing WQI in the study area. The comparison of performance evaluation metric shows that the MLR model has the higher accuracy compared to other models in the first scenario in terms of 1, 1.4572*10–08, 2.1418*10–08, 1.2573*10–10%, and 3.1708*10–08% for R, MAE, RMSE, RAE, and RRSE, respectively. The second scenario was executed with less error rate by using the RF model with 0.9984, 1.9942, 3.2488, 4.693, and 5.9642 for R, MAE, RMSE, RAE, and RRSE, respectively. The outcomes of this paper would be of interest to water planners in terms of WQI for improving sustainable management plans of groundwater resources.
Validation of analytical model and identification of salt effect on wellbore temperature in underbalanced drilling
Authors: Olayiwola Olatunji , Nguyen Vu , Bello Opeyemi , Osunwoke Ebuka , Guo Boyun , Teodoriu Catalin
Published: November 2021

Understanding the behavior of the borehole temperature recovery process, which influences drilling operations, requires an adequate estimation of fluid temperature. The presence of salt in a saline formation changes the composition of the annular fluid and has a significant impact on the fluid temperature distribution during drilling operations. As a result, while drilling a saline formation, it is vital to examine the key parameter that determines an accurate estimate of fluid temperature. Using python software and statistical quantitative methods, this study proposes a simplified user-friendly computational system that analyzes the drilling fluid systems performance evaluation and selection optimization.

The fluid temperature distribution of X Field in China was analyzed using Shan mathematical model as a base model. When compared to MWD data from the field, the model predicted the temperature distribution of the field with less than 10% error. An adjustment factor was introduced to the base model to accommodate for changes in annular fluid composition while drilling a saline formation. The findings show that salt concentration has an impact on fluid temperature distribution during drilling. The fluid temperature at the wellbore condition changes by at least 7% with both high and low adjustment factors. Because the salt in the formation inflow dissolves in the drilling fluid near the annulus, the rheology of the fluid combination changes.