bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of a New Integrated and Multidisciplinary Cognitive Rehabilitation Program Based on Mindfulness and Reminiscence Therapy in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Pilot Study
Authors: Reitano Maria Rita , Guidetti Matteo , Maiorana Natale Vincenzo , De Sandi Angelica , Carusi Fabrizio , Rosci Chiara , Ruggiero Fabiana , Poletti Barbara , Ticozzi Nicola , Mameli Francesca , Barbieri Sergio , Silani Vincenzo , Priori Alberto , Ferrucci Roberta
Published: January 2023

Background: Mindfulness trainings have shown promising results as treatment for behavioural symptoms in several pathologies. In addition, mindfulness protocols induced an improvement in memory and attention. Therefore, mindfulness could be an effective intervention for patients affected by Parkinson’s disease (PD) and mild cognitive impairment (MCI), who are characterized by both behavioural and cognitive dysfunctions. Methods: We assessed differences in Montreal Cognitive Assessment (MoCA) scores and in Beck Depression Inventory II (BDI-II) scores in patients affected by PD and MCI enrolled in two different rehabilitation programs (an experimental vs. an usual structured program for cognitive rehabilitation). Participants in the experimental group (MILC-tr) underwent innovative rehabilitation program involving mindfulness and reminiscence activities. Assessments were performed before (T0) and at the end of the rehabilitation program (T1). Results: Friedman test showed a significant improvement between timepoints in MoCA global score (x2 = 4.000, p = 0.046), MoCA memory sub-scale score (x2 = 4.571, p = 0.033), and BDI-II cognitive and affective factors (x2 = 4.000, p = 0.046) only for patients in MILC-tr group. Mann–Whitney test showed a significant difference between group comparing differences in Δ scores between T0 and T1 in the MoCA memory sub-scale score (U = 190.50, p = 0.035). Conclusions: Mindfulness-based rehabilitation programs could be effective in patients affected by PD and MCI.
Liver Resection and Transplantation Following Yttrium-90 Radioembolization for Primary Malignant Liver Tumors: A 15-Year Single-Center Experience
Authors: Aliseda Daniel , Martí-Cruchaga Pablo , Zozaya Gabriel , Rodríguez-Fraile Macarena , Bilbao José I. , Benito-Boillos Alberto , Martínez De La Cuesta Antonio , Lopez-Olaondo Luis , Hidalgo Francisco , Ponz-Sarvisé Mariano , Chopitea Ana , Rodríguez Javier , Iñarrairaegui Mercedes , Herrero José Ignacio , Pardo Fernando , Sangro Bruno , Rotellar Fernando
Published: January 2023

Radioembolization (RE) may help local control and achieve tumor reduction while hypertrophies healthy liver and provides a test of time. For liver transplant (LT) candidates, it may attain downstaging for initially non-candidates and bridging during the waitlist. Methods: Patients diagnosed with HCC and ICC treated by RE with further liver resection (LR) or LT between 2005–2020 were included. All patients selected were discarded for the upfront surgical approach for not accomplishing oncological or surgical safety criteria after a multidisciplinary team assessment. Data for clinicopathological details, postoperative, and survival outcomes were retrospectively reviewed from a prospectively maintained database. Results: A total of 34 patients underwent surgery following RE (21 LR and 13 LT). Clavien–Dindo grade III-IV complications and mortality rates were 19.0% and 9.5% for LR and 7.7% and 0% for LT, respectively. After RE, for HCC and ICC patients in the LR group, 10-year OS rates were 57% and 60%, and 10-year DFS rates were 43.1% and 60%, respectively. For HCC patients in the LT group, 10-year OS and DFS rates from RE were 51.3% and 43.3%, respectively. Conclusion: Liver resection after RE is safe and feasible with optimal short-term outcomes. Patients diagnosed with unresectable or high biological risk HCC or ICC, treated with RE, and rescued by LR may achieve optimal global and DFS rates. On the other hand, bridging or downstaging strategies to LT with RE in HCC patients show adequate recurrence rates as well as long-term survival.
Probiotic Bacteria Cannot Mitigate the Adverse Effects of Radioactive Iodine-131 Treatment
Authors: Mortazavi Seyed Mohammad Javad , Nowroozi Saba , Haghani Masoud , Zarrini-Monfared Zinat , Gheisari Farshid , Sihver Lembit
Published: January 2023

Thyroid carcinoma is the most common cancer of the endocrine system, accounting for 12% of all cancer cases in adolescents in the United States. Radioiodine therapy plays a key role in differentiated thyroid cancer (DTC) treatment. This double-blind, randomized, placebo-controlled clinical trial was aimed at evaluating the effect of probiotics supplementation in reducing the acute side-effects of radioiodine therapy in PTC patients. Fifty-six patients were randomly divided into four groups: one placebo and three intervention groups. The probiotics product used in this study was LactoCare (ZistTakhmir Co., Tehran, Iran), a multi-strain commercially available symbiotic containing 12 strains of probiotic species including Lactobacillus strains, Bifidobacteria strains, and Streptococcus thermophilus, plus Fructo-oligosaccharides as the prebiotic. Group 0 was our placebo group (no probiotics), while the other three groups received probiotics capsules for 2/4 days, starting only 2 days prior to radioiodine therapy, only 4 days after radioiodine therapy or 2 days prior and 4 days after radioiodine therapy. Six patients were withdrawn during the study because of poor compliance or at their own request. The symptoms reported by patients including data about the incidence and duration of each complication were recorded. The probiotics’ effectiveness was confirmed for dry mouth and taste loss or change when it was administered prior to the radioiodine treatment. The benefit was not confirmed for other radiation-induced complications such as pain and swelling in the neck, nausea and vomiting, salivary gland swelling, and diarrhea. Further large-scale clinical trials are warranted to improve our knowledge in this quickly evolving field.
Mycosis Fungoides and Sézary Syndrome: Microenvironment and Cancer Progression
Authors: Dobos Gabor , Lazaridou Ingrid , de Masson Adèle
Published: January 2023

Mycosis fungoides and Sézary syndrome are epidermotropic cutaneous lymphomas, and both of them are rare diseases. Mycosis fungoides is the most frequent primary cutaneous lymphoma. In about 25% of patients with mycosis fungoides, the disease may progress to higher stages. The pathogenesis and risk factors of progression in mycosis fungoides and Sézary syndrome are not yet fully understood. Previous works have investigated inter- and intrapatient tumor cell heterogeneity. Here, we overview the role of the tumor microenvironment of mycosis fungoides and Sézary syndrome by describing its key components and functions. Emphasis is put on the role of the microenvironment in promoting tumor growth or antitumor immune response, as well as possible therapeutic targets. We focus on recent advances in the field and point out treatment-related alterations of the microenvironment. Deciphering the tumor microenvironment may help to develop strategies that lead to long-term disease control and cure.
Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress
Authors: Melis Nicolas , Rubera Isabelle , Giraud Sebastien , Cougnon Marc , Duranton Christophe , Poet Mallorie , Jarretou Gisèle , Thuillier Raphaël , Counillon Laurent , Hauet Thierry , Pellerin Luc , Tauc Michel , Pisani Didier F.
Published: January 2023

Through kidney transplantation, ischemia/reperfusion is known to induce tissular injury due to cell energy shortage, oxidative stress, and endoplasmic reticulum (ER) stress. ER stress stems from an accumulation of unfolded or misfolded proteins in the lumen of ER, resulting in the unfolded protein response (UPR). Adaptive UPR pathways can either restore protein homeostasis or can turn into a stress pathway leading to apoptosis. We have demonstrated that N1-guanyl-1,7-diamineoheptane (GC7), a specific inhibitor of eukaryotic Initiation Factor 5A (eIF5A) hypusination, confers an ischemic protection of kidney cells by tuning their metabolism and decreasing oxidative stress, but its role on ER stress was unknown. To explore this, we used kidney cells pretreated with GC7 and submitted to either warm or cold anoxia. GC7 pretreatment promoted cell survival in an anoxic environment concomitantly to an increase in xbp1 splicing and BiP level while eiF2α phosphorylation and ATF6 nuclear level decreased. These demonstrated a specific modulation of UPR pathways. Interestingly, the pharmacological inhibition of xbp1 splicing reversed the protective effect of GC7 against anoxia. Our results demonstrated that eIF5A hypusination inhibition modulates distinctive UPR pathways, a crucial mechanism for the protection against anoxia/reoxygenation.
Study on Effect of High-Entropy Alloy Binder on Microstructure and Properties of WC Cemented Carbide Doped with Rare Earth Oxide
Authors: Qin Yongqiang , Yuan Jian , Zhuang Yi , Ma Bing , Luo Laima , Wu Yucheng
Published: January 2023

The AlCoCrFeNi powder was added to WC powder as a binder and Y2O3/ZrO2 was doped by the wet chemical method as grain-growth inhibitors. The WC-Y2O3-ZrO2-10AlCoCrFeNi composite powders were sintered by spark plasma sintering to obtain an alloy. The microstructure and properties of the cemented carbide were studied. The result showed that the rare-earth-oxide (Y2O3/ZrO2)-refined grain size of the alloy and the high-entropy alloy binder provided the alloy with better hardness and toughness. The AlCoCrFeNi diffused slowly between the WC grains because of a delayed diffusion effect and Cr having a low affinity for the WC matrix. During the dynamic process of the WC particles’ dissolution and precipitation growth, the Fe, Co, and Ni that had a better affinity for the WC matrix diffused and distributed more smoothly, which increased the strength and toughness of the alloy. When the temperature of the SPS sintering was 1250 °C, the WC-Y2O3-ZrO2-10AlCoCrFeNi cemented carbide had the best properties, which was a Vickers hardness of 1888.14 HV and a fracture toughness of 14.76 MPa·m1/2.
Azaphilones Pigments from the Fungus Penicillium hirayamae
Authors: Pavesi Coralie , Flon Victor , Genta-Jouve Grégory , Pramil Elodie , Escargueil Alexandre , Nasir Adeel , Montier Tristan , Franck Xavier , Prado Soizic
Published: January 2023

The use of fungal pigments as dyes is attractive for various industries. Fungal pigments arise a strong interest because they are suitable for large-scale industrial production and have none of the drawbacks of synthetic pigments. Their advantages over synthetic or vegetal dyes mark them as a prime target. Azaphilones are fungal polyketides pigments bearing a highly oxygenated pyranoquinone bicyclic core produced by numerous species of ascomyceteous and basidiomyceteous fungi. In order to find new azaphilones dyes, the fungal strain Penicillium hirayamae U., a known producer of azaphilone but, chemically, barely studied so far, was investigated by molecular networking and led to the isolation of three new azaphilones, penazaphilone J-L, along with the known penazaphilone D, isochromophilone VI, and sclerketide E. Their structures were determined based on extensive NMR and the absolute configurations by ECD. All compounds were evaluated for their cytotoxic activity against human cell lines and human pathogenic-resistant strains.
Ultraviolet Nanosecond Laser-Ablated Groove Analysis of 2.5D Cf/SiC Composites
Authors: Zhang Tangyong , Liu Fei , Liu Yao , Wu Chongjun , Liang Steven Y.
Published: January 2023

The 2.5D Cf/SiC composite is a typical heterogeneous material with the characteristics of anisotropy, which makes it difficult to predict the size and damage removed by the traditional contact removal process. This paper adopted the ultraviolet nanosecond laser to ablate the Cf/SiC composites by considering the heterogeneous structure’s effect. The ablated groove topography and size prediction are effective in revealing the machined quality with predictable groove sizes. The effects of laser processing parameters on the groove morphology and surface thermally affected zone are investigated with the thermal removal mechanism. A regression model is established by considering the scanning times, scanning speed, laser power and pulse width as the main variables. In the regression models, the relative error values are all below 10%. It is revealed that the groove width diminishes with the scanning speed and increases as the laser power increases. However, the influence of the scanning times and pulse width is small, and the overall variation range is within ±10 μm. The results show that the arrangement direction of carbon fibers has an impact on laser processing, especially when the pulse width is 0.25 μs, upon which the opposite change occurs. Carbon fiber grooves are not obvious and are barely observed in the laser processing of the parallel carbon fiber direction, and the grooves are slightly uneven. This study could be helpful in analyzing the grooves of Cf/SiC affected by the laser processing process, which could support the hybrid machining of the Cf/SiC composites.
Multisite Quality Improvement Initiative to Identify and Address Racial Disparities and Deficiencies in Delivering Equitable, Patient-Centered Care for Multiple Myeloma—Exploring the Differences between Academic and Community Oncology Centers
Authors: Mikhael Joseph R. , Sullivan Shelby L. , Carter Jeffrey D. , Heggen Cherilyn L. , Gurska Lindsay M.
Published: January 2023

Treatment of multiple myeloma (MM) is complex; however, with equal access to care, clinical outcomes for Black patients match those in other patient groups. To reveal and begin to address clinical practice barriers to equitable, patient-centered MM care, this quality improvement (QI) initiative assessed patient electronic medical records (EMRs) and surveyed patients and providers at two large hospital systems and four community-based practices. For the educational intervention, providers participated in feedback-focused grand rounds sessions to reflect on system barriers and develop action plans to improve MM care. EMR reviews revealed infrequent documentation of cytogenetics and disease staging at community-based practices compared to large hospital systems. In surveys, providers from each care setting reported different challenges in MM care. Notably, the goals of treatment for patients and providers aligned at community clinics while providers and patients from large hospital systems had discordant perspectives. However, providers in community settings underreported race-associated barriers to care and identified different factors impacting treatment decision-making than Black patients. Relative to pre-session responses, providers were more likely to report high confidence after the educational sessions in aligning treatment decisions with guidelines and clinical evidence and shared decision-making (SDM). This QI study identified discordant perceptions among providers at large hospital systems and community-based practices in providing quality MM care. Provider education yielded increased confidence in and commitment to patient-centered care.
Wild Felid Diversity, Space Use and Activity Patterns in the Eastern Himalaya, India
Authors: Bashir Tawqir , Bhattacharya Tapajit , Poudyal Kamal , Sathyakumar Sambandam
Published: January 2023

Species with similar resource requirements cannot coexist for long. To facilitate co-existence, carnivores adapt different strategies to partition the available resources in space and time. In high-altitude ecosystems with limited resources the operation becomes complex. We assessed species diversity and spatio-temporal resource partitioning among felid species inhabiting the intricate habitats of Khangchendzonga Biosphere Reserve (KBR), Eastern Himalaya. We used systematic camera trap surveys along with abundance and overlap indices to generate information on their space use and activity patterns. We recorded six species of felids belonging to five genera, including four species of global conservation importance. The differential use of space by felids was observed with respect to the habitat types determined by sharp altitudinal gradients with varied levels of spatial and altitudinal overlap. Maximum overlap was observed among Asiatic golden cat Catopuma temminckii, jungle cat Felis chaus and clouded leopard Neofelis nebulosa. The felids had distinct activity profiles from one other, particularly between golden cat and leopard cat Prionailurus bengalensis. Pianka’s index also provided weak evidence for temporal overlap among species. The overall results indicate that habitat heterogeneity facilitates primary separation at the spatial scale, although species are also segregated temporally. Golden cat was the most adaptive felid in the area, depicting a peculiar pattern of spatio-temporal segregation with other species. We suspect either intense competition or dietary segregation among some species, and propose a further investigation of their diet and the activity patterns of their prey. The study presents an early template of carnivore community organization in resource-scarce high-altitude environments, thus, offering huge ecological and conservation significance.
Analysis of the Electric Vehicle Charging Stations Effects on the Electricity Network with Artificial Neural Network
Authors: Olcay Kadir , Çetinkaya Nurettin
Published: January 2023

In this study, the effects of electric vehicles, whose usage rate is increasing day by day in the world, on the existing electricity grid have been studied. EV charging stations and similar non-linear loads cause various harmful effects on power systems such as phase imbalances, the effect of harmonic formation, energy quality, voltage, and current imbalance. The study focuses on the harmonic effects of EV charging stations at the point where they are connected to the grid and at lower voltage levels by using IEEE 6-, 14-bus, and 30-bus test power systems. In addition to the existing loads in these grid systems, the effects on the grid as a result of drawing electrical energy from the grid for charging electric vehicles are investigated. These effects have shown how these charging stations on the grid have changed, considering the fact that the number of electric vehicles and the number of charging stations increased over the years when a single electric vehicle provided energy from the grid, and the grid was not renewed. The response of the network to the increase in the load that will occur in addition to the current loads, its harmonic effects, and the effects of the current grid on the increase in the electric vehicle growth rate over the years have been predicted and examined by using artificial neural networks. Solution suggestions are presented for power networks in similar situations.
Innovative Method of Extraction of Humic Substances from Digested Sludge and Assessment of the Impact of Their on the Growth of Selected Plants
Authors: Anielak Anna M. , Kłeczek Aneta , Łuszczek Bartosz
Published: January 2023

The paper describes a new, proprietary method of HS extraction from digested sewage sludge. HS was extracted using the processes of dissolving organic substances and precipitating mineral micropollutants. The obtained substances were tested by determining their IR spectrum, elemental composition, and content of micropollutants and comparing them with HS obtained using the classical method. Using Phytotestkit, it was shown that HSs isolated from digested sewage sludge contain relatively large amounts of the nutrients necessary for plants (including N and P) and are a good component of a biostimulating substance. The obtained HS contains more ammonium and phosphorus ions. During extraction, inorganic impurities (including heavy metals) are reduced, and the humic product does not contain pathogens, parasites, and their spores. The method is simple, economically justified, and can be used on an industrial scale.
An Enhancement Method Based on Long Short-Term Memory Neural Network for Short-Term Natural Gas Consumption Forecasting
Authors: Liu Jinyuan , Wang Shouxi , Wei Nan , Yang Yi , Lv Yihao , Wang Xu , Zeng Fanhua
Published: January 2023

Artificial intelligence models have been widely applied for natural gas consumption forecasting over the past decades, especially for short-term consumption forecasting. This paper proposes a three-layer neural network forecasting model that can extract key information from input factors and improve the weight optimization mechanism of long short-term memory (LSTM) neural network to effectively forecast short-term consumption. In the proposed model, a convolutional neural network (CNN) layer is adopted to extract the features among various factors affecting natural gas consumption and improve computing efficiency. The LSTM layer is able to learn and save the long-distance state through the gating mechanism and overcomes the defects of gradient disappearance and explosion in the recurrent neural network. To solve the problem of encoding input sequences as fixed-length vectors, the layer of attention (ATT) is used to optimize the assignment of weights and highlight the key sequences. Apart from the comparisons with other popular forecasting models, the performance and robustness of the proposed model are validated on datasets with different fluctuations and complexities. Compared with traditional two-layer models (CNN-LSTM and LSTM-ATT), the mean absolute range normalized errors (MARNE) of the proposed model in Athens and Spata are improved by more than 16% and 11%, respectively. In comparison with single LSTM, back propagation neural network, support vector regression, and multiple linear regression methods, the improvement in MARNE exceeds 42% in Athens. The coefficient of determination is improved by more than 25%, even in the high-complexity dataset, Spata.
Impact on Voltage Regulation in Medium Voltage Distribution Networks Due to the Insertion of Photovoltaic Generators
Authors: de Negreiros Gustavo Fernandes , Lobo Fábio Xavier , Torres Igor Cavalcante , Tiba Chigueru
Published: January 2023

The objective of this paper was to analyze the impacts caused by the operation of voltage regulators in electrical distribution networks and to evidence the number of operations in the face of short-duration voltage variation caused by the high intermittency of the connected PV generators. A real LV and MV feeder was used, modeled in OpenDSS software, based on normative standards, adjustments, and technical maneuvers strategically used by the local utility. The analyses considered the temporal variations for the photovoltaic generators and different load demand profiles connected to the feeder. The feeder was submitted to the demand curves varying the load percentage, framing it in high and conventional (nominal) load according to the profiles of consumers and prosumers connected. The simulations made it possible to observe the exacerbated elevation in the number of maneuvers performed by the voltage regulators of the network. The single-phase voltage regulators stood out by the elevation of control operations, causing premature wear of the PV generation equipment connected to the most loaded phase. It was observed that discrepancies in the power flow in the lines and the voltage levels at the busbars. The creation of strategies and decisions to correct these impacts caused to transformers and regulators is possible.
Effects on Frequency Stability of Power System for Photovoltaic High-Penetration Ratio Grid-Connected Power Generation
Authors: Guo Hui , Zheng Shuai , Zhang Donghai , Gao Pengfei , Miao Wenzhe , Zuo Zongliang
Published: January 2023

In this paper, the effects of three typical operation modes, namely short-circuit fault, load change, and chemical energy storage on the frequency of a regional power grid after photovoltaic asynchronous interconnection were studied with different penetration ratios, taking the power grid in Northern Henan Province as the research object. It was found that with an increase in the photovoltaic penetration ratio, the maximum value of the system frequency and the fluctuation amplitude gradually increased, and the power grid system in Northern Henan became less and less stable. With an increase in the penetration ratio, the peak value of the system frequency at the corresponding node gradually increased, and the valley value gradually decreased. With an increase in load, the peak value of the frequency curve gradually increased, and the valley value gradually decreased. When photoelectricity was connected to the grid through chemical energy storage, the system stability during a short-circuit fault and load change operation was significantly improved. Compared with that before energy storage, the frequency amplitude of the system after energy storage was reduced to approximately one tenth of the original. Compared with the case before energy storage, when the load changed, the frequency amplitude of the system decreased to approximately a quarter of the original.
Multi-Feature Data Fusion-Based Load Forecasting of Electric Vehicle Charging Stations Using a Deep Learning Model
Authors: Aduama Prince , Zhang Zhibo , Al-Sumaiti Ameena S.
Published: January 2023

We propose a forecasting technique based on multi-feature data fusion to enhance the accuracy of an electric vehicle (EV) charging station load forecasting deep-learning model. The proposed method uses multi-feature inputs based on observations of historical weather (wind speed, temperature, and humidity) data as multiple inputs to a Long Short-Term Memory (LSTM) model to achieve a robust prediction of charging loads. Weather conditions are significant influencers of the behavior of EV drivers and their driving patterns. These behavioral and driving patterns affect the charging patterns of the drivers. Rather than one prediction (step, model, or variables) made by conventional LSTM models, three charging load (energy demand) predictions of EVs were made depending on different multi-feature inputs. Data fusion was used to combine and optimize the different charging load prediction results. The performance of the final implemented model was evaluated by the mean absolute prediction error of the forecast. The implemented model had a prediction error of 3.29%. This prediction error was lower than initial prediction results by the LSTM model. The numerical results indicate an improvement in the performance of the EV load forecast, indicating that the proposed model could be used to optimize and improve EV load forecasts for electric vehicle charging stations to meet the energy requirements of EVs.
The Effect of the Welding Technology on the Thermal Performance of Welded Finned Tubes Used in Heat Exchangers
Authors: Adamiec Janusz , Urbańczyk Michał
Published: January 2023

Due to the use of welded finned tubes in heat exchangers, gas blocks are characterized by very good electric energy production performance, and their reliability can reach 98%. Finned tubes used in heat exchangers are usually welded. Such tubes should be characterised by the following properties: high thermal performance, good resistance to high-temperature corrosion in a flue gas atmosphere, and appropriate joint strength and hardness. The most popular technology for welding finned tubes is MAG. MAG-welded joints are characterised by considerable spattering, weld discontinuities (up to 60%), and non-axial fin alignment. Such irregularities result in a considerably reduced heat flux due to the heat transfer resistance occurring in the welded joint. It has been shown that with weld discontinuities of 20%, the thermal performance of welded finned tubes reduces considerably. This paper proposes the possibility of welding finned tubes with a laser. The thermal properties of laser-welded finned tubes were compared with those of MAG-welded tubes. It was found that the thermal performance of welded finned tubes was three times higher than that of plain tubes. However, the thermal performance was not found to be affected by the welding technology. The correct heat flow at the level of 95% occurs in the tube/fin joint even with joint penetration of 0.01 mm, however, the absence of metallic continuity in a joint results in a drastically reduced thermal performance (by 50%) and the overheating of fins, which affects their durability.
NIPAT as Non-Invasive Prenatal Paternity Testing Using a Panel of 861 SNVs
Authors: Giannico Riccardo , Forlani Luca , Andrioletti Valentina , Cotroneo Ettore , Termine Andrea , Fabrizio Carlo , Cascella Raffaella , Salvaderi Luca , Linarello Pasquale , Varrone Debora , Gigante Laura , Giardina Emiliano
Published: January 2023

In 1997, it was discovered that maternal plasma contains Cell-Free Fetal DNA (cffDNA). cffDNA has been investigated as a source of DNA for non-invasive prenatal testing for fetal pathologies, as well as for non-invasive paternity testing. While the advent of Next Generation Sequencing (NGS) led to the routine use of Non-Invasive Prenatal Screening (NIPT or NIPS), few data are available regarding the reliability and reproducibility of Non-Invasive Prenatal Paternity Testing (NIPPT or NIPAT). Here, we present a non-invasive prenatal paternity test (NIPAT) analyzing 861 Single Nucleotide Variants (SNV) from cffDNA through NGS technology. The test, validated on more than 900 meiosis samples, generated log(CPI)(Combined Paternity Index) values for designated fathers ranging from +34 to +85, whereas log(CPI) values calculated for unrelated individuals were below −150. This study suggests that NIPAT can be used with high accuracy in real cases.
Global Research Trends for Unmanned Aerial Vehicle Remote Sensing Application in Wheat Crop Monitoring
Authors: Nduku Lwandile , Munghemezulu Cilence , Mashaba-Munghemezulu Zinhle , Kalumba Ahmed Mukalazi , Chirima George Johannes , Masiza Wonga , De Villiers Colette
Published: January 2023

Wheat is an important staple crop in the global food chain. The production of wheat in many regions is constrained by the lack of use of advanced technologies for wheat monitoring. Unmanned Aerial Vehicles (UAVs) is an important platform in remote sensing for providing near real-time farm-scale information. This information aids in making recommendations for monitoring and improving crop management to ensure food security. This study appraised global scientific research trends on wheat and UAV studies between 2005 and 2021, using a bibliometric method. The 398 published documents were mined from Web of Science, Scopus, and Dimensions. Results showed that an annual growth rate of 23.94% indicates an increase of global research based on wheat and UAVs for the surveyed period. The results revealed that China and USA were ranked as the top most productive countries, and thus their dominance in UAVs extensive usage and research developments for wheat monitoring during the study period. Additionally, results showed a low countries research collaboration prevalent trend, with only China and Australia managing multiple country publications. Thus, most of the wheat- and UAV-related studies were based on intra-country publications. Moreover, the results showed top publishing journals, top cited documents, Zipf’s law authors keywords co-occurrence network, thematic evolution, and spatial distribution map with the lack of research outputs from Southern Hemisphere. The findings also show that “UAV” is fundamental in all keywords with the largest significant appearance in the field. This connotes that UAV efficiency was important for most studies that were monitoring wheat and provided vital information on spatiotemporal changes and variability for crop management. Findings from this study may be useful in policy-making decisions related to the adoption and subsidizing of UAV operations for different crop management strategies designed to enhance crop yield and the direction of future studies.
Yield and Quality of Winter Jujube under Different Fertilizer Applications: A Field Investigation in the Yellow River Delta
Authors: Zhang Yanpeng , Yu Hui , Yao Haiyan , Deng Tingting , Yin Kuilin , Liu Jingtao , Wang Zhenhua , Xu Jikun , Xie Wenjun , Zhang Zaiwang
Published: January 2023

Winter jujube (Ziziphus jujuba Mill. cv. Dongzao) is highly popular due to its attractive taste and flavor of fruits. However, its cultivation is facing a serious obstacle for the substantial decrease in fruit soluble solids contents. In this study, four commonly-used fertilization types, including organic manure application (OM), combined application of manure and NPK fertilizer (OC), NPK fertilizer application at high rate (HC) and NPK fertilizer application at low rate (LC) were selected to investigate their effects on soil and fruit properties. Results showed that fertilization influenced soil organic matter (SOM) and NPK contents. Fruit yield decreased as HC (3.37tha−1) > OC (2.81tha−1) > OM (2.14tha−1) > LC (1.92tha−1).Total soluble solids (TSS), protein contents, and the ratio of TSS to titratable acid (TA) were highest in OM, followed by OC, LC and HC. TSS and TSS/TA ratio in OM were 23.0% and 27.0% higher than those in HC. Fruit yield was significantly positively correlated with soil available N, vegetative shoot leaf N, and total topsoil P contents. TSS and TSS/TA ratio both significantly positively correlated with SOM of topsoil and leaf P contents. Combined application of organic and inorganic fertilizers should be the optimal mode for winter jujube production.
Standardization of an In Vitro Seed Germination Protocol Compared to Acid Scarification and Cold Stratification Methods for Different Raspberry Genotypes
Authors: Pergolotti Valeria , Marcellini Micol , Contreras Elida , Mezzetti Bruno , Gambardella Marina , Capocasa Franco , Sabbadini Silvia
Published: January 2023

In raspberry (Rubus idaeus L.) breeding programs, seed double dormancy causes delayed and low germination rates. In this study, an in vitro germination protocol was developed to increase raspberry seed germination rate and decrease germination time. This protocol was optimized on the cultivars “Polka” and “Tulamagic”, specifically, their open-pollinated seeds, by applying two different cutting types (transverse, or longitudinal), followed by two different treatments (direct in vitro culture at 24 °C, or 2 weeks at 4 °C followed by in vitro culture at 24 °C). The best results for both cultivars were obtained when seeds were cut transversally and directly cultured in vitro at 24 °C (germination rate 73–78%, starting germination time 4 days after treatment). The optimized in vitro protocol was applied to 14 different combination crosses, observing a germination frequency around 87%, and speed in line with “Polka” and “Tulamagic”. These results were compared to those from the 14 cross combinations having undergone acid scarification (95% H2SO4 for 30 min) and cold stratification (3 months), which, in comparison, only yielded a 25% average germination rate. The optimized in vitro protocol favors high germination efficiency for all raspberry genotypes tested, and presents advantages for the standardization of germination time and reduction in the parental genotypes’ impact on germination rate.
Predicting the Stability of Organic Matter Originating from Different Waste Treatment Procedures
Authors: Wang Yan , Tan Lekun , Garnier Patricia , Houot Sabine , Jimenez Julie , Patureau Dominique , Zeng Yang
Published: January 2023

Recycling organic wastes into farmland faces a double challenge: increasing the carbon storage of soil while mitigating CO2 emission from soil. Predicting the stability of organic matter (OM) in wastes and treatment products can be helpful in dealing with this contradiction. This work proposed a modeling approach integrating an OM characterization protocol into partial least squares (PLS) regression. A total of 31 organic wastes, and their products issued from anaerobic digestion, composting, and digestion-composting treatment were characterized using sequential extraction and three-dimension (3D) fluorescence spectroscopy. The apportionment of carbon in different fractions and fluorescence spectra revealed that the OM became less accessible and biodegradable after treatments, especially the composting. This was proven by the decrease in CO2 emission from soil incubation. The PLS model successfully predicted the stability of solid digestate, compost, and compost of solid digestate in the soil by using only the characterized variables of non-treated wastes. The results suggested that it would be possible to predict the stability of OM from organic wastes after different treatment procedures. It is helpful to choose the most suitable and economic treatment procedure to stabilize labile organic carbon in wastes and hence minimize CO2 emission after the application of treatment products to the soil.
Urban Public Spaces as Restorative Environments: The Case of Ljubljana
Authors: Polajnar Horvat Katarina , Ribeiro Daniela
Published: January 2023

In this study, we used a survey to examine how urban residents in Ljubljana, Slovenia, value and use distinct urban public spaces. Specifically, we were interested to assess if urban public spaces in the city are used/perceived as restorative environments. To do this, we addressed the question: To what extent do restorative dimensions differ in nine selected urban public spaces, varying in size, design, amenities, number of visitors, and, most importantly, degree of naturalness? Results from survey allowed to determine to what extent the selected urban public spaces in Ljubljana differ in terms of their perceived degree of restoration. We hypothesized that urban public spaces with a higher degree of naturalness in the city have a higher restoration value than urban public spaces with a lower degree of naturalness. Surprisingly, the urban public space that was above average on most restorative dimensions was the Old Town. These results are somewhat at odds with the attentional restoration theory, which states that the combination of dimensions is most typical of natural environments. However, this could be an indicator of the effectiveness of the city’s current policies to improve the quality of life for its citizens.
Regional Transport of PM2.5 from Coal-Fired Power Plants in the Fenwei Plain, China
Authors: Lu Pan , Deng Shunxi , Li Guanghua , Tuheti Abula , Liu Jiayao
Published: January 2023

The Fenwei Plain (FWP) remains one of the worst PM2.5-polluted regions in China, although its air quality has improved in recent years. To evaluate the regional transport characteristics of PM2.5 emitted by coal-fired power plants in the FWP in wintertime, the primary PM2.5, SO2, and NOx emissions from coal-fired power plants with large units (≥300 MW) in 11 cities of the area in January 2019 were collected based on the Continuous Emission Monitoring System (CEMS). The spatial distribution and source contribution of primary and secondary PM2.5 concentrations were investigated using the Weather Research and Forecast (WRF) model and the California Puff (CALPUFF) model. The results showed that secondary PM2.5 was transported over a larger range than primary PM2.5 and that secondary nitrate was the main component of the total PM2.5 concentration, accounting for more than 70%. High concentrations of primary, secondary, and total PM2.5 mainly occurred in the Shaanxi region of the FWP, especially in Xianyang, where the PM2.5 concentrations were the highest among the 11 cities, even though its pollutant emissions were at moderate levels. The PM2.5 concentrations in Sanmenxia and Yuncheng primarily came from regional transport, accounting for 64% and 68%, respectively, while those in other cities were dominated by local emissions, accounting for more than 63%. The results may help to understand the regional transport characteristics of pollutants emitted from elevated point sources over a complex terrain.
Impacts of Climate Change and Land Use/Cover Change on the Net Primary Productivity of Vegetation in the Qinghai Lake Basin
Authors: Zhang Jinlong , Qi Yuan , Yang Rui , Ma Xiaofang , Zhang Juan , Qi Wanqiang , Guo Qianhong , Wang Hongwei
Published: January 2023

The Qinghai Lake Basin acts as a natural barrier, preventing the western desert from spreading eastward. This is an important link in preserving the ecological stability of the northeastern region of the Qinghai–Tibet Plateau (QTP). Therefore, quantitative research into the net primary productivity (NPP) of vegetation and its driving force in the Qinghai Lake Basin is required. The effects of land use/cover change (LUCC) and climate change on NPP in the Qinghai Lake Basin were studied using R-contribution ratio and partial correlation analysis methods using MOD17A3H products, Land Use/Land Cover (LULC) data, and meteorological data. (1) The LULC of the Qinghai Lake Basin showed a trend that “the area of grassland, cultivated land, and unused land continued to decrease, while the area of other LULC types increased” from 2000 to 2020, according to the study’s findings. Grassland, water bodies, construction land, and unused land dominated the mutual transformation of LULC types. (2) The NPP of the basin showed a growing trend, with a growth rate of 3.93 gC·m–2·a–1 before 2010 and 0.88 gC·m–2·a–1 after 2010. Significant regional heterogeneity was found in NPP, with gradients decreasing from southeast to northwest. (3) The impact of LUCC on overall NPP changes had gradually increased. Climate change has been the primary driver of NPP changes in the Qinghai Lake Basin over the last 20 years.
Chronic Effects of Asymmetric and Symmetric Sport Load in Varsity Athletes across a Six Month Sport Season
Authors: Bonavolontà Valerio , Gallotta Maria , Zimatore Giovanna , Curzi Davide , Ferrari Dafne , Vinciguerra Maria , Guidetti Laura , Baldari Carlo
Published: January 2023

The relation between specific sport practice and possible spine modifications is unclear. The aim of this study was to investigate the effects of different sports on the spine in adult varsity athletes across a six month sports season. Forty-four athletes (24.5 ± 3 years) were divided into two groups according to the typology of the sport practiced: the symmetric sports group (S, 22 athletes: track and field running, n = 14; cycling, n = 8), and the asymmetric sports group (A, 22 athletes: tennis, n = 22). The participants’ spines were evaluated with Formetric® 4D rasterstereographic analysis at the beginning (BL), in the middle (INT), and at the end (FIN) of the season. Twenty-five parameters were measured in an average 4D modality. The results showed that the intervention factor (BL vs. FIN) had a significant effect on dimple distance (p < 0.05) and on left lateral deviation (BL vs. FIN and INT vs. FIN, p < 0.01 and p < 0.01, respectively). Statistical differences were found for the sport typology factor for pelvic antero-retroversion and right lateral deviation. For left lateral deviation, no modulation was found for the sport typology. Asymmetric versus symmetric sport loads showed small statistical differences in a non-professional sample of adult athletes. The practice of asymmetric sports should also be encouraged without exceeding the total number of hours per week.
Evaluating the Effects of Capacity Building Initiatives and Primary Care Networks in Singapore: Outcome Harvesting of System Changes to Chronic Disease Care Delivery
Authors: Chen Andrew Teik Hong , Koh Gerald Choon-Huat , Fong Ngan Phoon , Lim Jeremy Fung Yen , Hildon Zoe Jane-Lara
Published: January 2023

The high tertiary healthcare utilisation in Singapore due to an ageing population and increasing chronic disease load has resulted in the establishment of primary care networks (PCNs) for private general practitioners (GPs) to provide team-based, community care for chronic diseases. A total of 22 PCN leaders and programme managers from 10 PCNs participated in online group discussions and a survey. Outcome harvesting was used to retrospectively link the intended and unintended outcomes to the programme initiatives and intermediate results (IRs). The outcomes were generated, refined and verified before shortlisting for analysis. About 134 positive and 22 negative PCN outcomes were observed since inception in 2018. By establishing PCN headquarters and entrusting PCN leaders with the autonomy to run these, as well as focusing policy direction on GP onboarding, GP engagements and clinical governance, the programme successfully harnessed the collective capabilities of GPs. Developments in the organisation (IR1) and monitoring and evaluation (IR4) were the top two contributors for positive and negative outcomes. Sustainable practice and policy changes represented 46% and 20% of the positive outcomes respectively. Sustainable positive outcomes were predominantly contributed by funding, clear programme policy direction and oversight. Conversely, most negative outcomes were due to the limited programme oversight especially in areas not covered by the programme policy.
Twelve Weeks of Web-Based Low to Moderate Physical Activity Breaks with Coordinative Exercises at the Workplace Increase Motor Skills but Not Motor Abilities in Office Workers—A Randomised Controlled Pilot Study
Authors: Scharf Carina , Tilp Markus
Published: January 2023

Integrating physical activity interventions at the workplace can have positive effects on the employees’ health. This study aimed to evaluate a physical activity break with coordinative exercises (PAB) including juggling and balance tasks and to assess its effects on motor abilities. Thirty-two university employees were randomly allocated to an intervention (IG:20) or a control (CG:12) group. The IG participated two times per week for 12 weeks in a PAB with a duration of 15 to 20 min. We measured the unimanual, bimanual finger, and hand dexterity with the Purdue Pegboard Test, the reaction time with the Fall Stick Test, and the dynamic balance with the Y Balance Test. Juggling performance was assessed by measuring the time(s) of performing a three-ball-cascade. Furthermore, an evaluation of the PAB was executed. Participants in the IG improved their juggling performance after six and twelve weeks. These increases were significantly different compared to the CG. However, no other parameters changed significantly. The evaluation showed that the PAB was enjoyable and led to subjective improvements in the participants health and working routine. To conclude, PAB can lead to improvements in juggling performance, subjective health, and the working routine.
Attitudes toward Homosexuality and Same-Sex Marriage: The Roles of Parental Attitudes, Traditional Gender Role Values, and Filial Piety
Authors: Ng Ting Kin , Lee Ting Hin , Yuen Hazyle , Chan Wai
Published: January 2023

Past studies have suggested that people’s attitudes toward homosexuality and same-sex marriages are influenced by their parents’ attitudes toward homosexuality. The current study intends to contribute to a more nuanced understanding of these associations by proposing a moderated mediation model incorporating traditional gender role values as a mediator and filial piety as a moderator. One hundred and fifteen adults (33.9% male and 66.1% female) aged from 18 to 36 years (M = 21.47, SD = 3.78) from Hong Kong completed an online questionnaire. The results of the latent moderated structural equations model showed that filial piety significantly moderated the indirect effects of negative parental attitudes toward homosexuality on attitudes toward homosexuality and attitudes toward same-sex marriage via traditional gender role values. The indirect effects were only significant when filial piety was high or medium but not when filial piety was low. These findings unpack the mechanisms underlying the effects of negative parental attitudes toward homosexuality on attitudes toward homosexuality and same-sex marriage and provide the boundary condition for the indirect effects of negative parental attitudes toward homosexuality on attitudes toward homosexuality and same-sex marriage through traditional gender role values.