bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable Tourism Empowered by Social Network Analysis to Gain a Competitive Edge at a Historic Site
Authors: Linnes Cathrine , Itoga Holly , Agrusa Jerome , Lema Joseph
Published: October 2021

Social media has had a strong presence in many people’s lives over the last decade. In addition, social media platforms have allowed people to share opinions, provide advice on numerous factors, including where to visit, as well as to stay connected and maintain friendships. The hospitality and tourism industry, however, can make effective use of these powerful tools for marketing purposes, collaboration and information sharing, and service offerings. Reviewing social media followers’ behaviors and interests offers a wealth of information and valuable data for a variety of tourism organizations. This case study focuses on an analysis of the social networks applied to the fortified town of Fredrikstad in Norway. The data used in this research study were collected from the Facebook site of the tourist authority. The results of this research project demonstrate the strengths of applying a social network analysis to a dataset, which can aid in the strategic direction of a tourism destination. The conversations of the greatest interest can successfully be identified as well as the growth of the online network. This paper adds knowledge to the literature through the application of a social network analysis regarding the success of a tourism destination and its future potential.
The Stochastic Gravitational Wave Background from Magnetars
Authors: Chowdhury Sourav Roy , Khlopov Maxim
Published: October 2021

Magnetars have already been a potential candidate as gravitational wave sources that could be detected by current and future terrestrial as well as ground-based gravitational wave detectors. In this article, we focus on the gravitational wave emission from the distorted rotating neutron stars. The deformation is assumed to be symmetric around an axis that is perpendicular to the rotation axis. The form is applied in the context of a neutron star whose magnetic field has been deformed on its own. By introducing the effects from all magnetars in the Universe, based on various proposed magnetic field configurations, such as poloidal and toroidal, the stochastic gravitational wave background can be generated. We choose to figure out exactly how the observations of the stochastic gravitational wave background should be used to understand much more about physics correlated with the magnetar behavior, based on the restriction on the ellipticity of the magnetar.
High-Throughput Next-Generation Sequencing Respiratory Viral Panel: A Diagnostic and Epidemiologic Tool for SARS-CoV-2 and Other Viruses
Authors: Sahajpal Nikhil S. , Mondal Ashis K. , Njau Allan , Petty Zachary , Chen Jiani , Ananth Sudha , Ahluwalia Pankaj , Williams Colin , Ross Ted M. , Chaubey Alka , DeSantis Grace , Schroth Gary P. , Bahl Justin , Kolhe Ravindra
Published: October 2021

Two serious public health challenges have emerged in the current COVID-19 pandemic namely, deficits in SARS-CoV-2 variant monitoring and neglect of other co-circulating respiratory viruses. Additionally, accurate assessment of the evolution, extent, and dynamics of the outbreak is required to understand the transmission of the virus. To address these challenges, we evaluated 533 samples using a high-throughput next-generation sequencing (NGS) respiratory viral panel (RVP) that includes 40 viral pathogens. The performance metrics revealed a PPA, NPA, and accuracy of 95.98%, 85.96%, and 94.4%, respectively. The clade for pangolin lineage B that contains certain distant variants, including P4715L in ORF1ab, Q57H in ORF3a, and S84L in ORF8 covarying with the D614G spike protein mutation, were the most prevalent early in the pandemic in Georgia, USA. The isolates from the same county formed paraphyletic groups, indicating virus transmission between counties. The study demonstrates the clinical and public health utility of the NGS-RVP to identify novel variants that can provide actionable information to prevent or mitigate emerging viral threats and models that provide insights into viral transmission patterns and predict transmission/resurgence of regional outbreaks as well as providing critical information on co-circulating respiratory viruses that might be independent factors contributing to the global disease burden.
Spillover of West Caucasian Bat Lyssavirus (WCBV) in a Domestic Cat and Westward Expansion in the Palearctic Region
Authors: Leopardi Stefania , Barneschi Ettore , Manna Giuseppe , Zecchin Barbara , Priori Pamela , Drzewnioková Petra , Festa Francesca , Lombardo Andrea , Parca Fabio , Scaravelli Dino , Maroni Ponti Andrea , De Benedictis Paola
Published: October 2021

In June 2020, a cat from Arezzo (Italy) that died from a neurological disease was diagnosed with West Caucasian Bat Lyssavirus (WCBV). The virus retained high identity across the whole-genome with the reference isolate found in 2002 from a Russian bent-winged bat. We applied control measures recommended by national regulations, investigated a possible interface between cats and bats using visual inspections, bioacoustics analyses and camera trapping and performed active and passive surveillance in bats to trace the source of infection. People that were exposed to the cat received full post-exposure prophylaxis while animals underwent six months of quarantine. One year later, they are all healthy. In a tunnel located near the cat’s house, we identified a group of bent-winged bats that showed virus-neutralizing antibodies to WCBV across four sampling occasions, but no virus in salivary swabs. Carcasses from other bat species were all negative. This description of WCBV in a non-flying mammal confirms that this virus can cause clinical rabies in the absence of preventive and therapeutic measures, and highlights the lack of international guidelines against divergent lyssaviruses. We detected bent-winged bats as the most probable source of infection, testifying the encroachment between these bats and pets/human in urban areas and confirming free-ranging cats as potential hazard for public health and conservation.
Toll-like Receptors in Viral Encephalitis
Authors: Gern Olivia Luise , Mulenge Felix , Pavlou Andreas , Ghita Luca , Steffen Imke , Stangel Martin , Kalinke Ulrich
Published: October 2021

Viral encephalitis is a rare but serious syndrome. In addition to DNA-encoded herpes viruses, such as herpes simplex virus and varicella zoster virus, RNA-encoded viruses from the families of Flaviviridae, Rhabdoviridae and Paramyxoviridae are important neurotropic viruses. Whereas in the periphery, the role of Toll-like receptors (TLR) during immune stimulation is well understood, TLR functions within the CNS are less clear. On one hand, TLRs can affect the physiology of neurons during neuronal progenitor cell differentiation and neurite outgrowth, whereas under conditions of infection, the complex interplay between TLR stimulated neurons, astrocytes and microglia is just on the verge of being understood. In this review, we summarize the current knowledge about which TLRs are expressed by cell subsets of the CNS. Furthermore, we specifically highlight functional implications of TLR stimulation in neurons, astrocytes and microglia. After briefly illuminating some examples of viral evasion strategies from TLR signaling, we report on the current knowledge of primary immunodeficiencies in TLR signaling and their consequences for viral encephalitis. Finally, we provide an outlook with examples of TLR agonist mediated intervention strategies and potentiation of vaccine responses against neurotropic virus infections.
Longitudinal Assessment of Lipoprotein(a) Levels in Perinatally HIV-Infected Children and Adolescents
Authors: van Genderen Jason G. , Van den Hof Malon , de Boer Claudia G. , Jansen Hans P. G. , van Deventer Sander J. H. , Tsimikas Sotirios , Witztum Joseph L. , Kastelein John J. P. , Pajkrt Dasja
Published: October 2021

HIV is an independent risk factor of cardiovascular disease (CVD); therefore, perinatally HIV-infected (PHIV) children potentially have a greater CVD risk at older age. Lipoprotein(a) (Lp(a)) is an established risk factor for CVD in the general population. To evaluate a potential increased CVD risk for PHIV children, we determined their lipid profiles including Lp(a). In the first substudy, we assessed the lipid profiles of 36 PHIV children visiting the outpatient clinic in Amsterdam between 2012 and 2020. In the second substudy, we enrolled 21 PHIV adolescents and 23 controls matched for age, sex and ethnic background on two occasions with a mean follow-up time of 4.6 years. We assessed trends of lipid profiles and their determinants, including patient and disease characteristics, using mixed models. In the first substudy, the majority of PHIV children were Black (92%) with a median age of 8.0y (5.7–10.8) at first assessment. Persistent elevated Lp(a) levels were present in 21/36 (58%) children (median: 374 mg/L (209–747); cut off = 300). In the second substudy, the median age of PHIV adolescents was 17.5y (15.5–20.7) and of matched controls 16.4y (15.8–19.5) at the second assessment. We found comparable lipid profiles between groups. In both studies, increases in LDL-cholesterol and total cholesterol were associated with higher Lp(a) levels. A majority of PHIV children and adolescents exhibited elevated Lp(a) levels, probably associated with ethnic background. Nonetheless, these elevated Lp(a) levels may additionally contribute to an increased CVD risk.
Screening of Porcine Innate Immune Adaptor Signaling Revealed Several Anti-PRRSV Signaling Pathways
Authors: Xu Yulin , Ye Mengxue , Zhang Youwen , Sun Shaohua , Luo Jia , Jiang Sen , Zhang Jiajia , Liu Xueliang , Shao Qi , Cao Qi , Zheng Wanglong , Meurens François , Chen Nanhua , Zhu Jianzhong
Published: October 2021

Porcine reproductive and respiratory syndrome virus (PRRSV) causes PRRS and is known to effectively suppress host innate immunity. The current strategies for controlling PRRSV are limited and complete understanding of anti-PRRSV innate immunity is needed. Here, we utilized nine porcine innate immune signaling adaptors which represent all currently known innate immune receptor signaling pathways for screening of anti-PRRSV activity. The analysis of PRRSV N gene transcription and protein expression both suggested that the multiple ectopic adaptors exhibited varying degrees of anti-PRRSV activities, with TRIF and MAVS most effective. To better quantify the PRRSV replication, the GFP signal of PRRSV from reverse genetics were measured by flow cytometry and similarly varying anti-PRRSV activities by different signaling adaptors were observed. Based on the screening data, and considering the importance of viral nucleic acid in innate immune response, endogenous TRIF, MAVS and STING were selected for further examination of anti-PRRSV activity. Agonist stimulation assay showed that MAVS and STING signaling possessed significant anti-PRRSV activities, whereas siRNA knockdown assay showed that TRIF, MAVS and STING are all involved in anti-PRRSV activity, with TLR3-TRIF displaying discrepancy in anti-PRRSV infection. Nevertheless, our work suggests that multiple pattern recognition receptor (PRR) signaling pathways are involved in anti-PRRSV innate immunity, which may have implications for the development of future antiviral strategies.
Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems
Authors: Trincado Valeria , Gala Rikhav P. , Morales Javier O.
Published: October 2021

Currently, most vaccines available on the market are for parental use; however, this may not be the best option on several occasions. Mucosal routes of administration such as intranasal, sublingual, and buccal generate great interest due to the benefits they offer. These range from increasing patient compliance to inducing a more effective immune response than that achieved through conventional routes. Due to the activation of the common mucosal immune system, it is possible to generate an effective systemic and local immune response, which is not achieved through parenteral administration. Protection against pathogens that use mucosal entry routes is provided by an effective induction of mucosal immunity. Mucosal delivery systems are being developed, such as films and microneedles, which have proven to be effective, safe, and easy to administer. These systems have multiple advantages over commonly used injections, which are simple to manufacture, stable at room temperature, painless for the patient since they do not require puncture. Therefore, these delivery systems do not require to be administered by medical personnel; in fact, they could be self-administered.
Metabolic Rewiring in the Tumor Microenvironment to Support Immunotherapy: A Focus on Neutrophils, Polymorphonuclear Myeloid-Derived Suppressor Cells and Natural Killer Cells
Authors: De Lerma Barbaro Andrea , Palano Maria Teresa , Cucchiara Martina , Gallazzi Matteo , Mortara Lorenzo , Bruno Antonino
Published: October 2021

Leukocytes often undergo rapid changes in cell phenotype, for example, from a resting to an activated state, which places significant metabolic demands on the cell. These rapid changes in metabolic demand need to be tightly regulated to support immune cell effector functions during the initiation and downregulation of an immune response. Prospects for implementing cancer immunotherapy also rest on the idea of optimizing the metabolic profile of immune cell effectors. Here, we examine this issue by focusing on neutrophils and NK cells as cells of increasing interest in cancer immunology and tumor immunometabolism, because they can be targeted or, in the case of NK, used as effectors in immunotherapy. In addition, neutrophils and NK cells have been shown to functionally interact. In the case of neutrophils, we also extended our interest to polymorphonuclear MDSC (PMN-MDSCs), since the granulocytic subset of MDSCs share many phenotypes and are functionally similar to pro-tumor neutrophils. Finally, we reviewed relevant strategies to target tumor metabolism, focusing on neutrophils and NK cells.
Laboratory and Semi-Pilot Scale Study on the Electrochemical Treatment of Perfluoroalkyl Acids from Ion Exchange Still Bottoms
Authors: Maldonado Vanessa Y. , Becker Michael F. , Nickelsen Michael G. , Witt Suzanne E.
Published: October 2021

The ubiquitous presence of perfluoroalkyl acids (PFAAs) in the environment remains a serious environmental concern. In this study, the electrochemical oxidation (EO) of PFAAs from the waste of ion exchange (IX) still bottoms was assessed at the laboratory and semi-pilot scales, using full boron-doped diamond (BDD) electrochemical cells. Multiple current densities were evaluated at the laboratory scale and the optimum current density was used at the semi-pilot scale. The results at the laboratory scale showed >99% removal of total PFAAs with 50 mA/cm2 after 8 h of treatment. PFAAs treatment at the semi-pilot scale showed 0.8-fold slower pseudo-first-order degradation kinetics for total PFAAs removal compared to at the laboratory scale, and allowed for >94% PFAAs removal. Defluorination values, perchlorate (ClO4−) generation, coulombic efficiency (CE), and energy consumption were also assessed for both scales. Overall, the results of this study highlight the benefits of a tandem concentration/destruction (IX/EO) treatment approach and implications for the scalability of EO to treat high concentrations of PFAAs.
Hyper-Nutrient Enrichment Status in the Sabalan Lake, Iran
Authors: Noori Roohollah , Ansari Elmira , Jeong Yong-Wook , Aradpour Saber , Maghrebi Mohsen , Hosseinzadeh Majid , Bateni Sayed M.
Published: October 2021

Lakes/reservoirs are rapidly deteriorating from cultural eutrophication due to anthropogenic factors. In this study, we aimed to (1) explore nutrient levels in the Sabalan dam reservoir (SDR) of northwest Iran, (2) determine the reservoir water fertility using the total phosphorus (TP) based and total nitrogen (TN) based Carlson trophic state indices, and (3) specify primary limiting factors for the reservoir eutrophication. Our field observations showed a state of hyper-nutrient enrichment in the SDR. The highest variation of TN in the reservoir water column happened when the reservoir was severely stratified (in August) while the highest variation of TP took place when the thermocline was attenuated with the deepening of the epilimnion (in October). Both TP and TN based trophic indicators classified the SDR as a hypereutrophic lake. TN:TP molar ratio averaged at the epilimnion indicated a P–deficiency in the reservoir during warm months whilst it suggested a co–deficiency of P and N in cold months. Given the hyper-nutrient enrichment state in the reservoir, other drivers such as water residence time (WRT) can also act as the main contributor of eutrophication in the SDR. We found that WRT in the SDR varied from hundreds to thousands of days, which was much longer than that of other reservoirs/lakes with the same and even much greater storage capacity. Therefore, both hyper-nutrient enrichment and WRT mainly controlled eutrophication in the reservoir. Given time consuming and expensive management practices for reducing nutrients in the watershed, changes in the SDR operation are suggested to somewhat recover its hypereutrophic state in the short-term. However, strategic long-term recovery plans are required to reduce the transition of nutrients from the watershed to the SDR.
Evaluation of the RF-Based Downscaled SMAP and SMOS Products Using Multi-Source Data over an Alpine Mountains Basin, Northwest China
Authors: Wen Yuanyuan , Zhao Jun , Zhu Guofeng , Xu Ri , Yang Jianxia
Published: October 2021

Passive microwave surface soil moisture (SSM) products tend to have very low resolution, which massively limits their application and validation in regional or local-scale areas. Many climate and hydrological studies are urgently needed to evaluate the suitability of satellite SSM products, especially in alpine mountain areas where soil moisture plays a key role in terrestrial atmospheric exchanges. Aiming to overcome this limitation, a downscaling method based on random forest (RF) was proposed to disaggregate satellite SSM products. We compared the ability of the downscaled soil moisture active passive (SMAP) SSM and soil moisture and ocean salinity satellite (SMOS) SSM products to capture soil moisture information in upstream of the Heihe River Basin by using in situ measurements, the triple collocation (TC) method and temperature vegetation dryness index (TVDI). The results showed that the RF downscaling method has strong applicability in the study area, and the downscaled results of the two products after residual correction have more details, which can better represent the spatial distribution of soil moisture. The validation with the in situ SSM measurements indicates that the correlation between downscaled SMAP and in situ SSM is better than downscaled SMOS at both point and watershed scales in the Babaohe River Basin. From the TC method, the root mean square error (RMSE) of the CLDAS (CMA land data assimilation system), downscaled SMAP and downscaled SMOS were 0.0265, 0.0255 and 0.0317, respectively, indicating that the downscaled SMAP has smaller errors in the study area than others. However, the soil moisture distribution in the study area shown by the SMOS downscaled results is closer than the downscaled SMAP to the degree of drought reflected by TVDI. Overall, this study suggests that the proposed RF-based downscaling method can capture the variation of SSM well, and the downscaled SMAP products perform significantly better than the downscaled SMOS products after the accuracy verification and error analysis of the downscaled results, and it should be helpful to facilitate applications for satellite SSM products at small scales.
Bioaugmentation-Enhanced Remediation of Crude Oil Polluted Water in Pilot-Scale Floating Treatment Wetlands
Authors: Rehman Khadeeja , Arslan Muhammad , Müller Jochen A. , Saeed Muhammad , Imran Asma , Amin Imran , Mustafa Tanveer , Iqbal Samina , Afzal Muhammad
Published: October 2021

Floating treatment wetlands (FTWs) are cost-effective systems for the remediation of polluted water. In FTWs, the metabolic activity of microorganisms associated with plants is fundamental to treatment efficiency. Bioaugmentation, the addition of microorganisms with pollutant-degrading capabilities, appears to be a promising means to enhance the treatment efficiency of FTWs. Here, we quantified the effect of bioaugmentation with a four-membered bacterial consortium on the remediation of water contaminated with crude oil in pilot-scale FTWs planted with Phragmites australis or Typha domingensis. The bacteria had been isolated from the endosphere and rhizosphere of various plants and carry the alkane hydroxylase gene, alkB, involved in aerobic hydrocarbon degradation. During a treatment period of 36 days, FTWs planted with P. australis achieved a reduction in hydrocarbon concentration from 300 mg/L to 16 mg/L with and 56 mg/L without bioaugmentation. In the FTWs planted with T. domingensis, respective hydrocarbon concentrations were 46 mg/L and 84 mg/L. The inoculated bacteria proliferated in the rhizoplane and in the plant interior. Copy numbers of the alkB gene and its mRNA increased over time in plant-associated samples, suggesting increased bacterial hydrocarbon degradation. The results show that bioaugmentation improved the treatment of oil-contaminated water in FTWs by at least a factor of two, indicating that the performance of full-scale systems can be improved at only small costs.
Measurement and theoretical analysis of sound absorption of simple cubic and hexagonal lattice granules
Authors: Sakamoto Shuichi , Il Kohei , Katayama Ibuki , Suzuki Kyosuke
Published: October 2021

A structure that possesses a continuous pore space packed with a granular material exhibits acoustic characteristics based on the principle similar to that of a porous material. Such a structure is used in low-noise pavement and ballast track. Therefore, predicting the sound absorption
characteristics of a clearance generated in a granular material from the particle diameter and the physical property of gas is useful for engineering. This article deals with two packing models, namely, the simple cubic lattice model and the hexagonal lattice model, to measure the sound absorption
coefficient of the structure packed with a granular material whose particle diameter is a few mm. Furthermore, a simple and accurate theoretical analysis that uses a one-dimensional transfer matrix method, which does not require numerous parameters, was performed. Comparing experimental values,
when the particle diameter of the granular material was 4 mm, the percentage of the boundary layer in the clearance was moderately larger than when the diameter was 8 mm; therefore, the effect of viscosity on it was larger, and its sound absorption coefficient peak was higher. Moreover, compared
with the simple cubic lattice, the hexagonal lattice had a higher percentage of boundary layer in the clearance because of its smaller volume of pore space. Then, the influence of friction due to the viscosity on it was higher, and its sound absorption coefficient peak was higher. In addition,
the theoretical values obtained by the proposed analysis method typically matched the experiment values.
Clear Evidence of LAMA5 Gene Biallelic Truncating Variants Causing Infantile Nephrotic Syndrome
Authors: Taniguchi Yukimasa , Nagano China , Sekiguchi Kiyotoshi , Tashiro Atsushi , Sugawara Noriko , Sakaguchi Haruhide , Umeda Chisato , Aoto Yuya , Ishiko Shinya , Rossanti Rini , Sakakibara Nana , Horinouchi Tomoko , Yamamura Tomohiko , Kondo Atsushi , Nagai Sadayuki , Nagase Hiroaki , Iijima Kazumoto , Miner Jeffrey H. , Nozu Kandai
Published: October 2021

Key Points

LAMA5 gene biallelic variants have been identified in only seven patients so far, and no functional analysis had been conducted for all but one.

We report three patients with LAMA5 biallelic truncating variants manifesting infantile nephrotic syndrome and in vitro heterotrimer assays.

We report one patient with SRNS with biallelic LAMA5 missense variants.

Background

Pathogenic variants in single genes encoding podocyte-associated proteins have been implicated in about 30% of steroid-resistant nephrotic syndrome (SRNS) patients in children. However, LAMA5 gene biallelic variants have been identified in only seven patients so far, and most are missense variants of unknown significance. Furthermore, no functional analysis had been conducted for all but one of these variants. Here, we report three patients with LAMA5 gene biallelic truncating variants manifesting infantile nephrotic syndrome, and one patient with SRNS with biallelic LAMA5 missense variants.

Methods

We conducted comprehensive gene screening of Japanese patients with severe proteinuria. With the use of targeted next-generation sequencing, 62 podocyte-related genes were screened in 407 unrelated patients with proteinuria. For the newly discovered LAMA5 variants, we conducted in vitro heterotrimer formation assays.

Results

Biallelic truncating variants in the LAMA5 gene (NM_005560) were detected in three patients from two families. All patients presented with proteinuria within 6 months of age. Patients 1 and 2 were siblings possessing a nonsense variant (c.9232C>T, p.[Arg3078*]) and a splice site variant (c.1282 + 1G>A) that led to exon 9 skipping and a frameshift. Patient 3 had a remarkable irregular contour of the glomerular basement membrane. She was subsequently found to have a nonsense variant (c.8185C>T, p.[Arg2720*]) and the same splice site variant in patients 1 and 2. By in vitro heterotrimer formation assays, both truncating variants produced smaller laminin α5 proteins that nevertheless formed trimers with laminin β1 and γ1 chains. Patient 4 showed SRNS at the age of 8 years, and carried compound heterozygous missense variants (c.1493C>T, p.[Ala498Val] and c.8399G>A, p.[Arg2800His]).

Conclusions

Our patients showed clear evidence of biallelic LAMA5 truncating variants causing infantile nephrotic syndrome. We also discerned the clinical and pathologic characteristics observed in LAMA5-related nephropathy. LAMA5 variant screening should be performed in patients with congenital/infantile nephrotic syndrome.
Astragalus dinawarii (section Incani), a New Species from the Talesh Mountains, Northwestern Iran
Authors: Bidarlord Mahmoud , Ghahremaninejad Farrokh
Published: October 2021

Astragalus dinawarii Bidarlord & F. Ghahrem. (Fabaceae) is described as a new species based on material collected on the Talesh Mountains, northwestern Iran. This species belongs to a large bifurcating section, Astragalus L. sect. Incani DC. Morphologically, it is close to A. bukanensis Maassoumi & Podlech, A. diversus Podlech & Maassoumi, and A. dilutuloides Maassoumi, F. Ghahrem. & Bagheri, sharing several densely hairy leaflets and stipitate legumes. This species is easily distinguished from similar species by a set of both vegetative and reproductive characters such as size, shape, number of leaflets, shorter calyx, and longer legume stipe. A detailed description and comparisons with similar taxa, color images, distribution and habitat, and conservation status of the new species are provided.
Vientos de cambios. El caso de la Mutual Federada Salud
Authors: Kobila María Teresa , Parolin Marisa Andrea , Chiaramoni Natalia Soledad , D’Avanzo María Laura , Gagliardini Graciela Ana
Published: October 2021

Las organizaciones post-Covid 2019 plantean problemáticas y desafíos abriendo un abanico de oportunidades para el apasionante mundo de la investigación. La Asociación Mutual Federada Salud se seleccionó como “caso de estudio único”. Se empleó metodología cualitativa y la entrevista virtual fueron el principal instrumento de relevamiento, proyectándose el abordaje de los siguientes objetivos: describir los cambios que se han implementado a partir del contexto de pandemia, reseñar las políticas y/o estrategias aplicadas, básicamente sobre el talento humano, inferir el estilo de gestión prevalente en la mutual y reflexionar sobre el proceso de cambio operado en la organización. Se reflexiona que los cambios fueron resultantes de decisiones políticas, sin las cuales su implementación hubiera sido imposible. Se procuró acrecentar las fortalezas y estrechar las debilidades para hacer operativos los cambios pretendidos que se dispuso mediante el empleo de tecnologías propias y el reforzamiento sistemático en la gestión del talento humano. El proceso de cambio no fue impulsado por la pandemia si bien se aceleró a consecuencia de la misma. La redefinición de valores fue ineludible para orientar el rumbo organizacional. La claridad en los compromisos de trabajo, la orientación a resultados específicos, la adaptación a los ambientes personales e institucionales, demuestra que el cambio es posible. Se infiere que el Gerente General-líder posee un “estilo mixto” que combina capacidades de gerenciar y liderar. Este proceso se interpreta como un auténtico cambio cultural, que se inició con un diagnóstico de la situación existente y llevó a redefinir los valores compartidos y consensuados por todos de los miembros en pos de la construcción conjunta de una floreciente y apropiada cultura organizacional.
Modelo para la gestión de riesgos de compliance
Authors: Páez Guillermo Néstor , Domínguez Fernández Raquel , Rabinowicz Sebastián , Tribolo Joaquín
Published: October 2021

La incertidumbre se presenta como la variable constante en todas las organizaciones del Siglo XXI y los desafíos a enfrentar son cada vez mayores y vertiginosos. La pandemia por Covid-19 ha demostrado la rapidez con la que pueden escalar las crisis y por qué las organizaciones deben estar preparadas para reaccionar y adaptarse velozmente. Las variables políticas, económicas, financieras, sociales, tecnológicas, ambientales, sanitarias, legales y regulatorias en las que las organizaciones desarrollan sus actividades tienden a ser cada vez más complejas y copiosas. El riesgo, siendo el efecto de la incertidumbre sobre el logro de los objetivos organizacionales, se manifiesta con más fuerza y relevancia, y su gestión adecuada se constituye como la base sólida, robusta y fundada para lograr una planificación efectiva y prevenir consecuencias no deseadas como el daño reputacional, financiero, la imposición de multas y sanciones, las pérdidas de negocio por contratos no ejecutables o la exclusión de licitaciones o subvenciones públicas, continuidad de la actividad organizacional, entre otros. El objetivo del artículo es orientar a las organizaciones Pymes para que puedan gestionar adecuadamente todos aquellos riesgos de incumplimientos que podrían acarrear actos de corrupción.
Nota editorial
Authors: Amigo Adriana Célide
Published: October 2021

"Con gran satisfacción, me encuentro escribiendo la nota editorial de nuestros Informes de Investigación, nuestro Número 6, Año 6. El año pasado, reflexionaba sobre que aquella no era una editorial común, pues se gestaba en un tiempo no común, en los escenarios de pandemia mundial, decretada por la OMS. Hoy, habiendo ya transcurrido 18 meses desde esa declaratoria, nos encontramos transitando la “nueva normalidad”, sin que todavía se haya declarado el fin de esa pandemia..."
Checking for ‘Checkpoints’: Using course design to redefine engagement in Early-warning system learner analytics
Authors: Henri Dominic C , Nattrass Stuart , Hubbard Katharine E , Morrell Lesley J , Scott Graham
Published: October 2021

In order to maintain pace with rising expectations to provide an ‘excellent learning environment’, higher education institutions across the world are turning to learner analytics to help allocate resources efficiently. However, the exponential increase of digital learning technologies has resulted in learner analytics sharing the same practical and ethical concerns as ‘big data’ in the wider context. This study provides an important ‘proof-of-concept’ that learner analytics is better served by data from theory driven course design, and not more data. We explore the potential of learner analytics combined with course design that incorporates regular, automated, low-stakes assignments to provide ‘checkpoints’ of student engagement. We show for a cohort of 424 foundation year students that attainment is best predicted by ‘checkpoint’ submission and not by a host of demographic and behavioural variables that have previously been identified as ‘early-warning indicators’. To conclude, we identify how the practice of integrating learner analytics and course design can help us better align our practice with ethical use of data guidelines for learner analytics and the recommendations from the literature.
Pencapaian Kemampuan Pemahaman Matematis Siswa Menggunakan Model Lesson Study pada Pembelajaran Matematika Ekonomi
Authors: Roesdiana Lessa , Hidayati Nita
Published: October 2021

Tujuan penelitian ini adalah menelaah peningkatan kemampuan pemahaman matematis siswa dengan menggunakan metode lesson study dibandingkan dengan pembelajaran langsung. Penelitian ini merupakan penelitian eksperimen dengan desain penelitian posttes only dengan populasi penelitian yaitu mahasiswa salah satu Perguruan Tinggi di Karawang. Instrumen tes mencakup tes kemampuan pemahaman matematis dengan indikator dan variabel yang diukur adalah tingkat kemampuan pemahaman matematis. Data diolah menggunkan Software SPSS versi 22 for Windows, hasil penelitian ini menunjukkan bahwa peningkatan kemampuan pemahaman matematis mahasiswa yang memperoleh pembelajaran dengan model lesson study lebih baik dibandingkan dengan pembelajaran langsung. Jadi dapat disimpulkan model lesson study dapat meningkatkan hasil belajar matematika khususnya mata kuliah matematika ekonomi.
Implementasi Model Pembelajaran Missouri Mathematics Project Berbantuan GeoGebra Untuk Meningkatkan Kemampuan Komunikasi Matematis Siswa SMP
Authors: Rosyid Abdul , Umbara Uba
Published: October 2021

Tujuan penelitian ini adalah untuk mengkaji secara mendalam peningkatan kemampuan komunikasi matematis siswa SMP yang memperoleh model pembelajaran Missouri Mathematics Project (MMP) berbantuan GeoGebra dibandingkan dengan peningkatan kemampuan komunikasi matematis siswa SMP yang memperoleh pembelajaran konvensional. Populasi dalam penelitian ini adalah siswa kelas VIII SMP Negeri 4 Kuningan Tahun Pelajaran 2017/2018. Pengambilan sampel dilakukan berdasarkan pertimbangan (sampling purposive). Kelas VIII F sebagai kelas eksperimen dan kelas VIII E sebagai kelas kontrol. Kelas eksperimen adalah kelas yang memperoleh model pembelajaran Missouri Mathematics Project (MMP) berbantuan GeoGebra sedangkan kelas kontrol adalah kelas yang memperoleh pembelajaran konvensional. Instrumen yang digunakan adalah instrumen tes yang selanjutnya dianalisis dengan uji perbedaan rata-rata. Hasil penelitian menunjukkan bahwa peningkatan kemampuan komunikasi matematis siswa yang memperoleh model pembelajaran Missouri Mathematics Project (MMP) berbantuan GeoGebra lebih baik dibandingkan dengan peningkatan kemampuan komunikasi matematis siswa yang mendapatkan pembelajaran konvensional.
Pengembangan Bahan Ajar Materi Pythagoras yang Berorientasi pada Kompetensi Abad 21 untuk Guru SMP
Authors: Maryamah Ida , Anriani Nurul , Fathurrohman Maman
Published: October 2021

Tujuan penelitian ini adalah untuk menghasilkan produk berupa buku ajar matematika yang berorientasi pada kompetensi abad 21 pada materi Pythagoras kelas VIII semester genap yang valid. Jenis penelitian ini merupakan penelitian pengembangan yang melipiuti tujuh langkah pokok, yaitu: analisis kebutuhan, kemampuan peneliti sebagai pengembang, produk yang dikembangkan, konsep produk, pengembangan produk, uji ahli, dan uji coba lapangan. Hasil penelitian berupa buku ajar matematika yang berorientasi pada kompetensi abad 21 pada materi Pythagoras kelas VIII yang valid. Kevalidan buku ajar diperoleh berdasarkan data dari angket penilaian para ahli, yaitu ahli materi, ahli bahasa, dan ahli media. Penilaian ahli materi mencapai kategori baik, ahli bahasa mencapai kategori sangat baik, dan ahli media mencapai kategori sangat baik. Sedangkan keterbacaan dan kepraktisan buku ajar diperoleh dari data angket penilaian guru matematika yang hasilnya mencapai kategori sangat baik.  Jadi dapat disimpulkan bahwa buku ajar matematika yang berorientasi pada kompetensi abad 21 pada materi Pythagoras layak digunakan dalam kegiatan pembelajaran matematika. DOI: https://doi.org/10.31235/osf.io/9z27d
Pandemi COVID-19 Memberdayakan Ibu-Ibu yang kehilangan Pekerjaan untuk Mengelolah Sedekah Jum’at ke Mesjid dan Panti asuhan di Kota Makassar
Authors: Daga Rosnaini , Salam Karta Negara
Published: October 2021

Pandemi COVID-19 di Indonesia pertama kali dideteksi pada tanggal 2 Maret 2020, ketika dua orang terkonfirmasi tertular dari seorang warga negara Jepang. Pada tanggal 9 April, pandemi sudah menyebar ke 34 provinsi dengan DKI Jakarta, Jawa Barat dan Jawa Tengah. Hingga 30 Juli 2021, Indonesia telah melaporkan 3.372.374 kasus positif menempati peringkat pertama terbanyak di Asia Tenggara. Dalam hal angka kematian, Indonesia menempati peringkat ketiga terbanyak di Asia dengan 92.311 kematian.  Di tengah situasi pandemi seperti ini tentunya telah menimbulkan dampak yang sangat besar terhadap seluruh aspek, utamanya dalam aspek perekonomian. Komunitas Gebug Jum’at di Kota Makassar memiliki salah satu program yang bernama Jumat Berkah dimana kegiatan dilaksanakan setiap hari jumat berupa pembagian makanan baik itu makanan berat maupun makanan ringan kepada warga di Kota Makassar dengan tujuan sedekah dan menyambung silaturahmi antar warga setempat yang notabenenya warga menengah ke bawah karena kegiatan dilakukan secara bersama-sama.
Upaya Peningkatan Pengetahuan Ibu Hamil Melalui Pendidikan Kesehatan Mengenai Anemia Kehamilan
Authors: Retnaningtyas Erma , Yonni Siwi Retno Palupi , Wulandari Anggrawati , Fauzianty Reski , Muflikah Lilik , Putri Adela , Suharti Eti , Wahyuni Sri
Published: October 2021

Anemia dalam kehamilan adalah kondisi ibu dengan kadar haemoglobin <11 gr% pada trimester I dan II, sedangkan pada trimester II kadar haemoglobin ibu hamil <10.5 gr%.  Ibu hamil yang mengalami anemia beresiko menjalani persalinan yang abnormal dan kecenderungan pendarahan yang berdampak pada morbiditas dan mortalitas pada ibu dan bayi. Tujuan pengabdian masyarakat ini adalah untuk Meningkatkan pengetahuan ibu hamil  tentang Anemia kehamilan. Kegiatan ini dilakukan dengan memberikan penyuluhan dengan leaflet kepada ibu hamil tentang anemia kehamilan dengan memberikan pre tes sebelum penyuluhan dan post tes sesudah penyuluhan. Penyuluhan ini dilaksanakan di Aula Desa Kota besi Hilir Kalimantan Tengah yang diikuti oleh 15 ibu hamil dengan menjalankan Protokol Kesehatan Covid 19. Hasil penyuluhan didapatkan Sebelum diberikan penyuluhan sebanyak 4 peserta (27%) dengan pengetahuan Baik dan setelah kegiatan terdapat peningkatan menjadi 12 peserta (80%) dengan penegtahuan Baik. Diharapkan untuk penyuluhan selanjutnya di fokuskan tentang Macam-macam anemia pada Ibu Hamil.
Обоснование параметров малогабаритной молотилки для обмолота початков кукурузы
Authors: Хажметова Залина Лиуановна , Шекихачев Юрий Ахметханович , Хажметов Лиуан Мухажевич , Шекихачева Людмила Зачиевна
Published: October 2021

Одно из ведущих мест среди зерновых и кормовых культур занимает кукуруза. Из  нее производят около 3500 видов продукции. Эта культура имеет большое значение как высоко энергетический корм для всех видов животных и птиц. В процессе производства зерна кукурузы наиболее трудоемким является сбор урожая – 60...80% от общих трудозатрат. В последнее наиболее трудоемким этапом сбора кукурузы является обмолот початков, качество которого характеризуется двумя основными показателями – травмированием зерна и недомолотом початков. На данный момент разработано большое количество молотилок различных по принципам и технологическими схемами обмолота. Существующие молотилки имеют большую производительность и предназначены для обмолота значительных объемов початков кукурузы. Однако в структуре выращивания кукурузы значительное место занимают небольшие посевы в частном секторе. После  сбора початков кукурузы их обмолачивают вручную или изготавливают разнообразные ручные и механические молотилки. Кроме того, в настоящее время, когда еще недостаточно изучена физическая природа процесса обмолота молотилками кукурузы и недостаточно разработана их теория, распределение молотилок по принципу обмолота ударом или перетиранием является не полным. В связи с этим в статье обоснована конструктивно-технологическая схема малогабаритной молотилки, обеспечивающей обмолот початков кукурузы в обертке при минимальном травмировании зерен. В результате теоретических исследований установлены рациональные значения конструктивно-технологических параметров разработанного молотильного устройства: влажность початков 12…22%; частота вращения молотильного барабана 300…400 мин-1; высота зубьев 12…18 мм; шаг зубьев 3…8 мм..
Сдобное печенье повышенной пищевой ценности
Authors: Алексеенко Елена Викторовна , Белявская Ирина Георгиевна , Зайцева Лариса Валентиновна , Уварова Анна Георгиевна
Published: October 2021

Приоритетным  направлением в разработке новых видов сдобного печенья является модификация традиционных рецептур и использование инновационных ингредиентов, обеспечивающих повышение пищевой ценности готовых изделий и формирующих их функциональную направленность. Проведен комплекс исследований по экспериментальному обоснованию, разработке рецептуры и технологических решений с целью получения сдобного печенья повышенной пищевой ценности на основе муки пшеничной из цельносмолотого зерна и жирового продукта энзимной переэтерификации с омега-3 жирными кислотами с добавлением микроводоросли спирулины. Изучено влияние выбранных ингредиентов на органолептические, физико-химические показатели и пищевую ценность готовых изделий. Показано, что разработанный вид сдобного печенья имеет достойные потребительские свойства, по физико-химическим показателям - соответствует требованиям ГОСТ 24901-2014 при некотором снижении показателя намокаемости. Доказано, что разработанное изделие характеризуется улучшенным липидным профилем: в составе жирных кислот содержится значительное количество ненасыщенных жирных кислот (55%) по сравнению со сдобным печеньем, полученным по традиционной рецептуре, выявлено наличие γ-линоленовой кислоты, отмечается десятикратное увеличение содержания эссенциальной линолевой кислоты; печенье может быть позиционировано как изделие, являющееся  источником незаменимых омега-3 жирных кислот (альфа-линоленовой более 0,2 г/100 г). Установлено, что  сдобное печенье, полученное по усовершенствованной рецептуре, является источником пищевых волокон (5,87 г/100 г продукта), магния (20% средней суточной потребности на 100 г) и железа (23% средней суточной потребности на 100 г) при низком содержании натрия (соли)  (42,3 мг/100г). Разработан комплект ТД  (ТУ, ТИ) (проект) на новое обогащенное сдобное печенье.
Влияние сортовых особенностей на количественные потери семенного и продовольственного картофеля при хранении
Authors: Шайдулина Татьяна Борисовна , Кондратенко Екатерина Петровна , Соболева Ольга Михайловна , Сартакова Оксана Алексеевна , Филипович Лариса Анатольевна , Мирошина Татьяна Александровна
Published: October 2021

Послеуборочное управление качеством клубней картофеля направлено на продление периода покоя и уменьшение потерь. Объектами исследований являлись клубни картофеля сортов Зекура, Гала, Ред Скарлет, Розара и Невский. Закладка опытов и количественные потери при хранении были определены по методике К.А. Пшеченкова с соавторами (2002) путем учета убыли массы (естественная убыль) и абсолютного отхода. Убыль массы определяли путем взвешивания фиксированных сеток. При хранении партии семенного картофеля в количестве 1500 тонн естественная убыль массы в среднем по сортам составляла 7,4 %, а абсолютный отход – 3,7 %. Убыль массы не превышала утвержденные нормативные нормы – 7,3 %. Абсолютный отход за счет гнили также был незначительным. Хорошую сохранность клубней мы связываем с тем, что в хозяйстве перед посадкой клубни семенного и продовольственного картофеля обрабатывают инсекто-фунгицидным протравителем Престиж с нормой расхода 10 л/т. Немаловажным является и соблюдение режима хранения (оптимум в основной период хранения (октябрь, ноябрь) лежит в пределах + 3 0С, декабрь, январь, февраль, март от +1,5 0С до +2 0С, ОВВ – 90 %...93 %; апрель +4 0С...+5 0С (семенной), ОВВ составляет 93 %…95 %). При хранении продовольственного картофеля потери за счет естественной убыли и абсолютного отхода были выше на 5,12 % и 1,47 % по сравнению с потерями семенного картофеля.Максимальные общие потери продовольственного картофеля при одном режиме хранения составляли у сорта Невский – 21,02 %, минимальные у сорта Гала – 14,7 %. Хорошо сохраняется сорт Зекура, потери за 9 месяцев хранения составляли 15,1 %.
Исследование физико-химического состава и технологических свойств овечьего и козьего молока в летний период лактации
Authors: Оспанов Асан Бекешович
Published: October 2021

В статье представлены результаты исследования физико-химического состава и технологических свойств овечьего и козьего молока в летний период лактации (с июня по август 2021 года) по 4 породам овец (Казахский тонкорунный, Южноказахский меринос, Едильбай и Иль Де Франц) и 4 породам коз (Зааненская, Нубийская, Альпийская и Бурская) из различных регионов Казахстана. В связи с тем, что количество и качество молока в значительной мeрe зависят от корма и соответственно сезона года, было изучено изменение содержания жира и белка. Разница в содержании белка в летний период  не превышает от  0,1 до 0,5 %, высокое содержание жира отмечалось в августе месяце (5,4% для овец и 3,6% для коз), а самое низкое в июле месяце (4,9 % для овец и 3,2 % для коз), это связано с климатическими условиями, в июле стоит жаркая погода и животные пьют больше воды и испытывают стрессы погодных аномалий а также летом основа рациона – пастбищный травостой, животные потребляют зеленый корм, содержащий много влаги. В августе значения показателей повышаются, так как многие кормовые культуры к этому времени созревают и питательная ценность соответственно возрастает.
The Effect of Artificial Amalgamates on Identifying Pathogenesis
Authors: Naveen Philip
Published: October 2021

The purpose of this research was to define acceleration in diagnostic procedures for airborne diseases. Airborne pathogenicity can be troublesome to diagnose due to intrinsic variation and overlapping symptoms. Coronavirus testing was an instance of a flawed diagnostic biomarker. The levels of independent variables (IV) were vanilla, sparse, and dense amalgamates formed from multilayer perceptrons and image processing algorithms. The dependent variable (DV) was the classification accuracy. It was hypothesized that if a dense amalgamate is trained to identify Coronavirus, the accuracy would be the highest. The amalgamates were trained to analyze the morphological patches within radiologist-verified medical imaging retrieved from online databanks. Using generative cross-validations, the DV was consulted for each amalgamate. Self-calculated t-tests supported the research hypothesis, with the dense amalgamate achieving 85.37% correct classification rate. The null hypothesis was rejected. Flaws within the databanks were possible sources of error. A new algorithm developed here identified Coronavirus, Mycobacterium, Carcinoma, and Pneumonia from 96-99% accuracy. Future enhancements involve tracking osteopenia/osteoporosis with the algorithm.