bluuebunny/crossref_metadata_2025 huggingface dataset:
Subclinical Ocular Motility Dysfunction and Extraocular Muscle Changes in Inactive Graves’ Orbitopathy
Authors: Lixi Filippo , Cuccu Alberto , Giannaccare Giuseppe , Onnis Matteo , Timofte Zorila Mihaela Madalina , Mariotti Stefano , Vacca Rosanna , Meloni Paola Elisa , Pisu Michela , Mura Chiara , Boi Francesco
Published: August 2024

This study aimed to investigate the presence of structural and functional changes in extraocular muscles (EMs) among patients with inactive Graves’ orbitopathy (GO) classified according to the Clinical Activity Score (CAS). Sixty-seven patients with Graves’ disease (GD) and inactive GO were included. The data collected included clinical parameters, thyroid function, autoantibody levels, EOM morphology via orbital ultrasound (US), and ocular motility. Patients were stratified into Red Filter Test (RFT)-positive or RFT-negative groups based on the presence or absence of latent diplopia during the RFT examination. Thirty-three patients (49.25%) exhibited latent diplopia on the RFT, despite not reporting double vision during standard ocular motility tests. Significant differences were observed between the two groups in terms of age, disease duration, intraocular pressure (IOP) elevation in up-gaze, and medial rectus muscle thickness (p < 0.05). No significant differences were found in thyroid status, TRAb and ATA levels, CASs, exophthalmos, or lateral rectus thickness between the two groups. This study revealed that in inactive GO, subclinical EM dysfunction and morphological changes may be present, which might not be apparent through routine ocular examinations. The RFT is effective in detecting latent diplopia, highlighting its utility in identifying subtle ocular motility issues and subclinical muscle involvement. Comprehensive evaluations combining functional tests like the RFT and imaging are essential for early detection of GO-related abnormalities, enabling tailored and prompt management and improving patient outcomes.
Cranio-Maxillo-Facial Reconstruction with Polyetheretherketone Patient-Specific Implants: Aesthetic and Functional Outcomes
Authors: Gugliotta Ylenia , Zavattero Emanuele , Ramieri Guglielmo , Borbon Claudia , Gerbino Giovanni
Published: August 2024

Background: Reconstructing cranio-maxillo-facial defects presents significant challenges. This study evaluates the results of polyetheretherketone patient-specific implants (PEEK PSIs) in primary and secondary cranio-maxillo-facial reconstructions, with a focus on aesthetic and functional outcomes and long-term complications. Methods: From October 2009 to February 2023, 45 patients underwent cranio-maxillo-facial reconstructions with PSIs. Patients aged 18 years or older, with a minimum follow-up period of 12 months, were included. The morpho-functional outcome was evaluated through a modified Katsuragy Scale, the Visual Analogue Scale (VAS) for pain, and four FACE-Q|Aesthetics© scales. Results: In total, 44 PSIs were placed in 37 patients (51.3% males; mean age 45.1 years). The main cause of the defect was the resection of a tumor (55.4%). Mean follow-up was 78.6 months. Clinical evaluations showed an improvement in the postoperative period both in patient’s and surgeon’s scores (p: 0.01 and p: 0.002, respectively). Subgroup analysis confirmed a significant improvement in patients undergoing cranioplasty (p = 0.02) and mandible reconstruction (p = 0.03). No cases of prosthesis dislocation, rupture, or long-term infection were recorded. Conclusions: PEEK PSIs offer significant advantages in craniofacial reconstructions. Despite challenges in predicting soft tissue adaptation, overall patient satisfaction was high with no long-term complications. Future improvements should focus on predicting and enhancing soft tissue adaptations.
Enhancing Adult Asthma Management: A Review on the Utility of Remote Home Spirometry and Mobile Applications
Authors: Wellmann Norbert , Marc Monica Steluta , Stoicescu Emil Robert , Pescaru Camelia Corina , Trusculescu Ana Adriana , Martis Flavia Gabriela , Ciortea Ioana , Crisan Alexandru Florian , Balica Madalina Alexandra , Velescu Diana Raluca , Fira-Mladinescu Ovidiu
Published: August 2024

Asthma is a prevalent chronic disease, contributing significantly to the global burden of disease and economic costs. Despite advances in treatment, inadequate disease management and reliance on reliever medications lead to preventable deaths. Telemedicine, defined as the use of information and communication technology to improve healthcare access, has gained global attention, especially during the COVID-19 pandemic. This systematic review examines the effectiveness of home monitoring systems in managing severe asthma. A systematic literature search was conducted in PubMed, Web of Science, Scopus, and Cochrane Library, focusing on studies from 2014 to 2024. Fourteen studies involving 9093 patients were analyzed. The results indicate that telemedicine, through tools such as mobile applications and portable spirometers, positively impacts asthma control, self-management, and quality of life. Home spirometry, in particular, shows strong agreement with clinic spirometry, offering a feasible alternative for continuous monitoring. Digital coaching and machine learning-based telemedicine applications also demonstrate significant potential in improving asthma outcomes. However, challenges such as technology accessibility, data privacy, and the need for standardized protocols remain. This review highlights the promise of telemedicine in asthma management and calls for further research to optimize its implementation and address existing barriers.
Superficial Anaplastic Lymphoma Kinase-Rearranged Myxoid Spindle Cell Neoplasm in the Buttock: A Case Report
Authors: Kim Jong-Hyup , Koh In-Chang , Kim Hoon , Lim Soo-Yeon , Choi Joon-Hyuk , Kwon Kun-Young
Published: August 2024

Anaplastic lymphoma kinase (ALK) is detected in both normal and oncological developmental tissues. Among ALK-related tumors, superficial ALK-rearranged myxoid spindle cell neoplasm (SAMS) is a rare, soft tissue tumor characterized by the immunophenotypical co-expression of CD34 and S100. Here, we describe a patient with this rare tumor and outline its clinical and radiological characteristics. A 28-year-old woman with diabetes, hypertension, and panic disorder presented with discomfort caused by a rubbery mass on the left buttock that had persisted for 10 years. Computed tomography revealed a multilobulated hypodense mass with small internal enhancing foci, posing challenges for the exact diagnosis of the lesion. The entire lesion was excised with clear resection margins. An 8.0 × 6.0 cm, well-circumscribed tumor with a lobular growth pattern was observed in the deep subcutaneous tissue. Light microscopy revealed epithelioid, ovoid, and spindle-shaped cells with a reticular cordlike pattern. Immunohistochemistry results were positive for S100, CD34, and vimentin. Break-apart fluorescence in situ hybridization assay results for ALK were also positive. These findings were consistent with those of SAMS. This case suggests that SAMS should be considered when identifying large nonspecific masses during clinical and imaging evaluation.
Insurance Types and All-Cause Mortality in Korean Cancer Patients: A Nationwide Population-Based Cohort Study
Authors: Shin Jinyoung , Bae Yoon-Jong , Kang Hee-Taik
Published: August 2024

Background: Economic deprivation is expected to influence cancer mortality due to its impact on screening and treatment options, as well as healthy lifestyle. However, the relationship between insurance type, premiums, and mortality rates remains unclear. This study investigated the relationship between insurance type and mortality in patients with newly diagnosed cancer using data from the Korean National Health Insurance Database. Methods: this retrospective cohort study included 111,941 cancer patients diagnosed between 1 January 2007 and 31 December 2008, with a median follow-up period of 13.41 years. The insurance types were categorized as regional and workplace subscribers and income-based insurance premiums were divided into tertiles (T1, T2, and T3). Results: Cox proportional hazards regression analysis adjusted for age, lifestyle factors, health metrics, and comorbidities showed workplace subscribers (n = 76,944) had a lower all-cause mortality hazard ratio (HR) (95% confidence interval [CI]: 0.940 [0.919–0.961]) compared to regional subscribers (n = 34,997). Higher income tertiles (T2, T3) were associated with lower mortality compared to the T1 group, notably in male regional and workplace subscribers, and female regional subscribers. Conclusion: The study identified that insurance types and premiums significantly influence mortality in cancer patients, highlighting the necessity for individualized insurance policies for cancer patients.
Association between Cardiovascular Risk Assessment by SCORE2 and Diverticulosis: A Cross-Sectional Analysis
Authors: Völkerer Andreas , Wernly Sarah , Semmler Georg , Flamm Maria , Radzikowski Konrad , Datz Leonora , Götz Nikolaus , Hofer Hannah , Aigner Elmar , Datz Christian , Wernly Bernhard
Published: August 2024

Background: The aim of this retrospective observational study was to examine the relationship between SCORE2 and the occurrence of colonic diverticula in a screening population without cardiovascular or gastrointestinal symptoms. SCORE2, recognized and supported by the European Society of Cardiology for cardiovascular risk assessment, served as the primary metric for the analysis in this investigation. Methods: We studied 3935 asymptomatic individuals undergoing screening colonoscopy. SCORE2 was calculated for each participant and categorized into three groups based on the following projected 10-year cardiovascular disease risk: SCORE2 0–4.9%, SCORE2 5–9.9%, and SCORE2 ≥ 10%. Logistic regression was used to assess the relationship between SCORE2 and diverticulosis. Results: SCORE2 was associated with the presence of diverticulosis (OR 1.09, 95%CI 1.07–1.10; p < 0.001) in univariable logistic regression, translating into an RR of 1.07 per unit increase. The association persisted after multivariable adjusting for metabolic syndrome (aOR 1.08; 95%CI 1.06–1.10; p < 0.001). Patients with high cardiovascular risk had higher rates of diverticulosis compared to those with lower risk: high risk (OR 2.00, 95%CI 1.71–2.33; p < 0.001); very high risk (OR 2.53, 95%CI 2.10–3.05; p < 0.001). This association remained after adjusting for metabolic syndrome: high risk (aOR 1.86, 95%CI 1.59–2.18; p < 0.001); very high risk (aOR 2.27, 95%CI 1.88–2.75; p < 0.001). Conclusions: A higher SCORE2 was found to be a suitable screening parameter for diverticular disease. This suggests a potential link between cardiovascular risk factors and colon diverticula development, warranting further research on whether optimizing cardiovascular risk factors could positively influence diverticular disease.
Ecological and Environmental Risk Warning Framework of Land Use/Cover Change for the Belt and Road Initiative
Authors: He Yinjie , Wu Dafang , Li Shuangcheng , Zhou Ping
Published: August 2024

Land use/cover change(LUCC) has a significant impact on the ecological environment. Within the Belt and Road Initiative (BRI), as the largest cross-spatial cooperation initiative in human history, one of the core issues is how to scientifically and effectively use and manage the land in the region to prevent the destruction of important ecological and environmental resources. In order to reduce impact on the latter, in this study, we used the bivariate choropleth–multiple-criteria decision analysis (BC-MCDA) method based on the connotation of the sustainable development goals to construct an ecological and environmental risk warning framework. We found that in the study area, 10.51% of the land has high ecological and environmental risk and importance, corresponding to conflict zones, which require special attention. Conflict areas are mainly distributed in the Gangetic Plain in India, the plains in central and southern Cambodia, the Indonesian archipelago, and the southern coastal areas of China. Due to the uneven spatial distributions of population and important ecological and environmental resources, the pressure on this type of land use is very high. A share of 8.06% of the land has high risk–low importance, corresponding to economic development zones. Following years of human development, the ecological and environmental value of this type of land is low. A share of 58.75% of the land has low risk and importance, corresponding to wilderness areas. The natural climatic conditions of this type of land are relatively poor, often characterized by a cold climate or water scarcity, and the human interference index is low. A share of 22.68% of the land has low risk–high importance, corresponding to ecological conservation areas, which are the most important areas for ecological function services for humans at present. Finally, we proposed development suggestions for each type of land.
Balkan Romance and Southern Italo-Romance: Differential Object Marking and Its Variation
Authors: Irimia Monica Alexandrina , Guardiano Cristina
Published: August 2024

The main goal of this article is to examine in detail an area of the grammar where standard Romanian, a Balkan Sprachbund language of the Romance phylum, and the Romance dialects of Southern Italy (here we used the dialect of Ragusa, in South-East Sicily) appear to converge, namely differential object marking (DOM). When needed, additional observations from non-Romance Balkan languages were also taken into account. Romanian and Ragusa use a prepositional strategy for differential marking, in a conjunctive system of semantic specifications, of which one is normally humanness/animacy. However, despite these unifying traits, this paper also focuses on important loci of divergence, some of which have generally been ignored in the previous literature. For example, Ragusa does not easily permit clitic doubling and shows differences in terms of binding possibilities and positions of direct objects, two traits that set it aside from both Romanian and non-Romance Balkan languages; additionally, as opposed to Romanian, its prepositional DOM strategy cannot override humanness/animacy. The comparative perspective we adopt allow us to obtain an in-depth picture of differential marking in the Balkan and Romance languages.
The Influence of the COVID-19 Pandemic on the Addressability to Treatment of Children with Hyperhidrosis—A Retrospective Study and a Short Review
Authors: Nastase Florentina , Nicolescu Alin Codrut , Busila Camelia , Marin Cristina Mihaela , Bogdan Goroftei Elena Roxana , Bogdan Mircea Pompiliu , Verenca Madalina Codruta , Barbu Raisa Eloise , Tatu Alin Laurentiu
Published: August 2024

Introduction: This study was carried out to demonstrate the negative influence that the COVID-19 pandemic had on the ability of patients to treat hyperhidrosis with iontophoresis. The purpose of this study is to identify the annual distribution of patients with hyperhidrosis as well as elaborate a curve of cases within the time interval studied. Methods: It is a retrospective study initiated in the Department of Neuropsychomotor Rehabilitation of the “Sf. Ioan” Emergency Clinical Hospital for Children, Galati, Romania, in which we analyzed the electronic database, the treatment, and the consultation files of all the children who presented between January 2013 and December 2023. We found 111 patients who met the inclusion criteria. Results: During the 3 years of the pandemic, the number of patients who came to our clinic suddenly dropped to 0. Limitations: This study was conducted on a relatively small number of patients in a Neuropsychomotor Recovery clinic. This study includes only patients with palmar and/or plantar hyperhidrosis who presented to the clinic for iontophoresis. Conclusion: Although it is a disease that significantly influences the quality of life, patients and their families do not consider hyperhidrosis to be an urgent problem that can be improved by treatment.
Xenobiology for the Biocontainment of Synthetic Organisms: Opportunities and Challenges
Authors: Gómez-Tatay Lucía , Hernández-Andreu José Miguel
Published: August 2024

Since the development of recombinant DNA technologies, the need to establish biosafety and biosecurity measures to control genetically modified organisms has been clear. Auxotrophies, or conditional suicide switches, have been used as firewalls to avoid horizontal or vertical gene transfer, but their efficacy has important limitations. The use of xenobiological systems has been proposed as the ultimate biosafety tool to circumvent biosafety problems in genetically modified organisms. Xenobiology is a subfield of Synthetic Biology that aims to construct orthogonal biological systems based on alternative biochemistries. Establishing true orthogonality in cell-based or cell-free systems promises to improve and assure that we can progress in synthetic biology safely. Although a wide array of strategies for orthogonal genetic systems have been tested, the construction of a host harboring fully orthogonal genetic system, with all parts operating in an orchestrated, integrated, and controlled manner, still poses an extraordinary challenge for researchers. In this study, we have performed a thorough review of the current literature to present the main advances in the use of xenobiology as a strategy for biocontainment, expanding on the opportunities and challenges of this field of research.
Outcomes of Kidney Transplantation in Highly HLA-Sensitized Patients Treated with Intravenous Immuno-Globulin, Plasmapheresis and Rituximab: A Meta-Analysis
Authors: Chandramohan Deepak , Adisa Oluwadamilola , Patel Devansh , Ware Erin , Eleti Navya , Agarwal Gaurav
Published: August 2024

(1) Background: We aimed to investigate the outcomes of human leukocyte antigen (HLA)-incompatible transplantation for patients who received desensitization with intravenous immunoglobulins (IVIg), plasmapheresis, and rituximab. (2) Methods: A comprehensive search of multiple electronic databases to identify studies that utilized desensitization was conducted. The random-effects model was used to calculate the pooled rates and the 95% confidence interval (CI). (3) Results: A total of 1517 studies were initially identified. From these, 16 studies met the inclusion criteria, encompassing 459 patients, with a mean age of 45 years, of whom 40.8% were male. CDC crossmatch was positive in 68.3% (95% CI: 43.5–85.8; I2 87%), and 89.4% (95% CI: 53.4–98.4%; I2 89.8%) underwent living-donor transplantation. The 1-year graft survival pooled rate was 88.9% (95% CI: 84.8–92; I2 0%) and the 5-year graft survival rate was 86.1% (95% CI: 81.2–89.9; I2 0%). The 1-year patient survival rate was 94.2% (95% CI: 91–96.3; I2 0%), and the 5-year patient survival rate was 88.9% (95% CI: 83.5–92.7%; I2 7.7%). The rate of antibody-mediated rejection was 37.7% (95% CI: 25–52.3; I2 80.3%), and the rate of acute cell-mediated rejection was 15.1% (95% CI: 9.1–24; I2 55%). (4) Conclusions: Graft and patient survival are favorable in highly sensitized patients who undergo desensitization using IVIg, plasmapheresis, and rituximab for HLA-incompatible transplantation.
Closing the Gaps: An Integrative Review of Yoga’s Benefits for Lymphedema in Breast Cancer Survivors
Authors: Freguia Sara , Platano Daniela , Donati Danilo , Giorgi Federica , Tedeschi Roberto
Published: August 2024

Background: Dissection of the axillary lymph nodes during surgery for breast cancer with lymph node involvement is burdened by a complication: lymphedema. Approximately half of women undergoing axillary dissection suffer from it, with a notable impact in terms of perceived discomfort, presented quality of life, and alteration of body image. There is also no shortage of problems in the patient’s social and professional life. Methods: The present review aims to select Randomized Controlled Trials (RCTs) present in the literature regarding the effects of yoga as an alternative therapy in patients with breast cancer-related lymphedema. A search of four databases was undertaken: Cochrane, Pubmed, Scopus, and Web of Science. The searches were conducted on 19 May 2024, and updated to 30 June 2024 without date limits. RCTs without language limitations, in any context, and with any yoga variant were considered. Results: The postulated search strings highlighted a total of 69 potentially eligible studies. The study selection system consisted of two levels of screening, (1) abstract selection and (2) full-text selection, for a total of three studies included in the review. The three RCTs included involved mixed treatment sessions in an outpatient setting with a yoga teacher and at home using a DVD. In the various studies, the outcome measures concerned quality of life, ROM, spinal mobility, limb volume, and tissue induration. Conclusions: According to the analysis of the data obtained, yoga as an alternative therapy could be useful if combined with the usual care routine in women with lymphedema related to sensory cancer, in terms of improving physical, professional, and emotional quality of life and reducing symptoms such as fatigue, pain, and insomnia. Furthermore, yoga could bring about a reduction in tissue induration of the limb, greater spinal mobility evaluated in terms of improvement of the pelvic and kyphotic angle, and greater strength in shoulder abduction.
Targeting Autophagy for Acetaminophen-Induced Liver Injury: An Update
Authors: Hinz Kaitlyn , Niu Mengwei , Ni Hong-Min , Ding Wen-Xing
Published: August 2024

Acetaminophen (APAP) overdose can induce hepatocyte necrosis and acute liver failure in experimental rodents and humans. APAP is mainly metabolized via hepatic cytochrome P450 enzymes to generate the highly reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI), which forms acetaminophen protein adducts (APAP-adducts) and damages mitochondria, triggering necrosis. APAP-adducts and damaged mitochondria can be selectively removed by autophagy. Increasing evidence implies that the activation of autophagy may be beneficial for APAP-induced liver injury (AILI). In this minireview, we briefly summarize recent progress on autophagy, in particular, the pharmacological targeting of SQSTM1/p62 and TFEB in AILI.
Active Learning for Rapid Targeted Synthesis of Compositionally Complex Alloys
Authors: Johnson Nathan S. , Mishra Aashwin Ananda , Kirsch Dylan J. , Mehta Apurva
Published: August 2024

The next generation of advanced materials is tending toward increasingly complex compositions. Synthesizing precise composition is time-consuming and becomes exponentially demanding with increasing compositional complexity. An experienced human operator does significantly better than a novice but still struggles to consistently achieve precision when synthesis parameters are coupled. The time to optimize synthesis becomes a barrier to exploring scientifically and technologically exciting compositionally complex materials. This investigation demonstrates an active learning (AL) approach for optimizing physical vapor deposition synthesis of thin-film alloys with up to five principal elements. We compared AL-based on Gaussian process (GP) and random forest (RF) models. The best performing models were able to discover synthesis parameters for a target quinary alloy in 14 iterations. We also demonstrate the capability of these models to be used in transfer learning tasks. RF and GP models trained on lower dimensional systems (i.e., ternary, quarternary) show an immediate improvement in prediction accuracy compared to models trained only on quinary samples. Furthermore, samples that only share a few elements in common with the target composition can be used for model pre-training. We believe that such AL approaches can be widely adapted to significantly accelerate the exploration of compositionally complex materials.
SBA-15 Type Mesoporous Silica Modified with Vanadium as a Catalyst for Oxidative and Extractive Oxidative Desulfurization Processes
Authors: Nurwita Ardian , Stawicka Katarzyna , Trejda Maciej
Published: August 2024

One of the current challenges is the reduction of sulfur emitted into the atmosphere, usually in the form of sulfur oxides generated by fossil fuel combustion. To achieve this goal, the sulfur content should be reduced in fuel. In this context, vanadium-containing materials based on SBA-15 mesoporous silica supports and two different sources of vanadium were prepared, characterized, and applied as catalysts for oxidative desulfurization (CODS) and extractive oxidative desulfurization processes (ECODSs). The novelty of this work was the comparative study of vanadium-containing materials in two desulfurization systems. The properties of the catalysts, the concentration and state of vanadium species, and their role in the catalytic process were examined by low-temperature nitrogen physisorption, XRD, UV-Vis, XPS, and chemisorption of pyridine combined with FTIR spectroscopy. The catalytic performance of the material prepared using ammonium metavanadate was superior to that of the catalyst obtained using vanadium(IV) oxide sulfate, which was explained by a higher concentration of vanadium species on the surface of the support and their lower oxidation state in the former. Both types of catalysts showed high activity and stability in the ECODS process.
Single CsPbBr3 Perovskite Microcrystals: From Microcubes to Microrods with Improved Crystallinity and Green Emission
Authors: Abiedh Khouloud , Salerno Marco , Hassen Fredj , Zaaboub Zouhour
Published: August 2024

All-inorganic perovskite materials are promising in optoelectronics, but their morphology is a key parameter for achieving high device efficiency. We prepared CsPbBr3 perovskite microcrystals with different shapes grown directly on planar substrate by conventional drop casting. We observed the formation of CsPbBr3 microcubes on bare indium tin oxide (ITO)-coated glass. Interestingly, with the same technique, CsPbBr3 microrods were obtained on (3-Aminopropyl) triethoxysilane (APTES)-modified ITO-glass, which we ascribe to the modification of formation kinetics. The obtained microcrystals exhibit an orthorhombic structure. A green photoluminescence (PL) emission is revealed from the CsPbBr3 microrods. Contact angle measurements, Fourier-transform infrared and PL spectroscopies confirmed that APTES linked successfully to the ITO-glass substrate. We propose a qualitative mechanism to explain the anisotropic growth. The microrods exhibited improved PL and a slower PL lifetime compared to the microcubes, likely due to the diminished occurrence of defects. This work demonstrates the importance of the substrate surface to control the growth of perovskite single crystals and to boost the radiative recombination in view of high-performance optoelectronic devices.
Real-Time Spectroscopic Ellipsometry for Flux Calibrations in Multi-Source Co-Evaporation of Thin Films: Application to Rate Variations in CuInSe2 Deposition
Authors: Sapkota Dhurba R. , Ramanujam Balaji , Pradhan Puja , Alaani Mohammed A. Razooqi , Shan Ambalanath , Heben Michael J. , Marsillac Sylvain , Podraza Nikolas J. , Collins Robert W.
Published: August 2024

Flux calibrations in multi-source thermal co-evaporation of thin films have been developed based on real-time spectroscopic ellipsometry (RTSE) measurements. This methodology has been applied to fabricate CuInSe2 (CIS) thin film photovoltaic (PV) absorbers, as an illustrative example, and their properties as functions of deposition rate have been studied. In this example, multiple Cu layers are deposited step-wise onto the same Si wafer substrate at different Cu evaporation source temperatures (TCu). Multiple In2Se3 layers are deposited similarly at different In source temperatures (TIn). Using RTSE, the Cu and In2Se3 deposition rates are determined as functions of TCu and TIn. These rates, denoted Reff, are measured in terms of effective thickness which is the volume per planar substrate area and accounts for surface roughness variations with deposition time. By assuming that all incident metal atoms are incorporated into the films and that the atomic concentrations in the deposited material components are the same as in single crystals, initial estimates of the Cu and In atom fluxes can be made versus TCu and TIn. Applying these estimates to the co-evaporation of a set of CIS films from individual Cu, In, and Se sources, atomic concentration corrections can be assigned to the Cu and In2Se3 calibration films. The corrections enable generation of a novel calibration diagram predicting the atomic ratio y = [Cu]/[In] and rate Reff within the TCu-TIn plane. Using this diagram, optimization of the CIS properties as a PV absorber can be achieved versus both y and Reff.
Digital Performance Management: An Evaluation of Manufacturing Performance Management and Measurement Strategies in an Industry 4.0 Context
Authors: Smith Nathaniel David , Hovanski Yuri , Tenny Joe , Bergner Sebastian
Published: August 2024

Manufacturing management and operations place heavy emphasis on monitoring and improving production performance. This supervision is accomplished through strategies of manufacturing performance management, a set of measurements and methods used to monitor production conditions. Over the last 30 years, the most prevalent measurement of traditional performance management has been overall equipment effectiveness, a percentile summary metric of a machine’s utilization. The technologies encapsulated by Industry 4.0 have expanded the ability to gather, process, and store vast quantities of data, creating the opportunity to innovate on how performance is measured. A new method of managing manufacturing performance utilizing Industry 4.0 technologies has been proposed by McKinsey & Company (New York City, NY, USA), and software tools have been developed by PTC Inc. (Boston, MA, USA) to aid in performing what they both call digital performance management. To evaluate this new approach, the digital performance management tool was deployed on a Festo (Esslingen, Germany) Cyber-Physical Lab (FCPL), an educational mock production environment, and compared to a digitally enabled traditional performance management solution. Results from a multi-day production period displayed an increased level of detail in both the data presented to the user and the insights gained from the digital performance management solution as compared to the traditional approach. The time unit measurements presented by digital performance management paint a clear picture of what and where losses are occurring during production and the impact of those losses. This is contrasted by the single summary metric of a traditional performance management approach, which easily obfuscates the constituent data and requires further investigation to determine what and where production losses are occurring.
A Mathematical Programming Model for Minimizing Energy Consumption on a Selective Laser Melting Machine
Authors: Yu Chunlong , Lin Junjie
Published: August 2024

The scheduling problem in additive manufacturing is receiving increasing attention; however, few have considered the effect of scheduling decisions on machine energy consumption. This research focuses on the nesting and scheduling problem of a single selective laser melting (SLM) machine to reduce total energy consumption. Based on an energy consumption model, a nesting and scheduling problem is formulated, and a mixed integer linear programming model is proposed. This model simultaneously determines part-to-batch assignments, part placement in the batch, and the choice of build orientation to reduce the total energy consumption of the SLM machine. The energy-saving potential of the model is validated through numerical experiments. Additionally, the effect of the number of alternative build orientations on energy consumption is explored.
Robust Invariance Conditions of Uncertain Linear Discrete Time Systems Based on Semidefinite Programming Duality
Authors: Yang Hongli , Wang Chengdan , Bi Xiao , Ivanov Ivan Ganchev
Published: August 2024

This article proposes a novel robust invariance condition for uncertain linear discrete-time systems with state and control constraints, utilizing a method of semidefinite programming duality. The approach involves approximating the robust invariant set for these systems by tackling the dual problem associated with semidefinite programming. Central to this method is the formulation of a dual programming through the application of adjoint mapping. From the standpoint of semidefinite programming dual optimization, the paper presents a novel linear matrix inequality (LMI) conditions pertinent to robust positive invariance. Illustrative examples are incorporated to elucidate the findings.
Efficacy of Botulinum Type A Injection for the Treatment of Postherpetic Neuralgia and Pruritus Persisting for More Than Four Years—A Case Report
Authors: Song Jihyun , Choi Sang Sik , Choi Seok Jun , Lee Chung Hun
Published: August 2024

Background: Postherpetic neuralgia (PHN) and postherpetic pruritus (PHP) are common complications of shingles that affect patients’ quality of life. PHN and PHP can be managed using various medications and interventional procedures; however, complications persisting for at least six months may hamper recovery. Subcutaneous injections of botulinum toxin type A (BTX-A) can control persistent PHN and PHP. Case presentation: A 71-year-old man presented at our hospital with itching and pain. He had been diagnosed with shingles in the ophthalmic branch of the trigeminal nerve one year previously. As the pain and itching persisted despite medication, a supraorbital nerve block, Gasserian ganglion block, epidural nerve block, and radiofrequency thermocoagulation were performed. A subcutaneous injection of BTX-A was administered into the ophthalmic area of the trigeminal nerve three years after the initial presentation. A decrease of >80% in pain and itching was reported after the injection; however, the left eyelid drooped and the eyeball shifted downward and outward immediately after the injection. No deterioration in vision or pupil dilation was observed, and almost complete resolution of these symptoms occurred spontaneously three months after the injection. Pain and itching continued to improve without further side-effects until six months after the injection. Conclusions: The subcutaneous injection of BTX-A may be an alternative treatment option for chronic and refractory neurological diseases such as PHN and PHP, which persist for four years and are resistant to conventional treatments. Nevertheless, care must be taken to minimize the risk of ptosis.
Influence of Inclusion Parameter and Depth on the Rotating Bending Fatigue Behavior of Bearing Steel
Authors: Xu Lijun , Zhan Zhonghua , Zhang Shulan
Published: August 2024

Inclusions are an important parameter affecting the fatigue life of materials. In this paper, the type, size, and quantity of inclusions in bearing steel were quantitatively analyzed using scanning electron microscopy and automatic scanning electron microscopy with an X-ray energy dispersive spectroscopy function. The effects of the inclusion parameters and positions on the rotating bending fatigue properties were analyzed using the rotating bending fatigue test. The results proved that for samples 1 and 2, the inclusions were mainly sulfides, Ti-containing inclusions, and their composite inclusions. For samples 3 and 4, the inclusions were mainly oxides or sulfide–oxide complexes. The number and maximum size of inclusions in sample 2 were relatively small. This was mainly due to the difference in the content of Al, S, and Ca elements in the different samples. The inclusion distance to the surface and the maximum inclusion size had a larger influence on the rotating bending fatigue life in comparison to the inclusion type. Moreover, nitride–oxides had a more detrimental effect on the rotating bending fatigue life as compared to the sulfide–oxide complex inclusions. A model was established on the basis of the inclusion size, depth, and stress by using the Python software. The simulation demonstrated that using five parameters fit well with the experiment results.
Analysis of Longitudinal Cracking and Mold Flux Optimization in High-Speed Continuous Casting of Hyper-Peritectic Steel Thin Slabs
Authors: Yuan Zhipeng , Zhu Liguang , Wang Xingjuan , Zhang Kaixuan
Published: August 2024

Longitudinal crack defects are a frequent occurrence on the surface of thin slabs during the high-speed continuous casting process. Therefore, this study undertakes a detailed analysis of the solidification characteristics of hyper-peritectic steel thin slabs. By establishing a three-dimensional heat transfer numerical model of the thin slab, the formation mechanism of longitudinal cracks caused by uneven growth of the initial shell is determined. Based on the mechanism of longitudinal crack formation, by adjusting the performance parameters of the mold flux, the contradiction between the heat transfer control and lubrication improvement of the mold flux is fully coordinated, further reducing the incidence of longitudinal cracks on the surface of the casting thin slab. The results show that, using the optimized mold flux, the basicity increases from 1.60 to 1.68, the F- mass fraction increases from 10.67% to 11.22%, the Na2O mass fraction increases from 4.35% to 5.28%, the Li2O mass fraction increases from 0.68% to 0.75%, and the carbon mass fraction reduces from 10.86% to 10.47%. The crystallization performance and rheological properties of the mold flux significantly improve, reducing the heat transfer performance while ensuring the lubrication ability of the molten slag. After optimizing the mold flux, a surface detection system was used to statistically analyze the longitudinal cracks on the surface of the casting thin slab. The proportion of longitudinal cracks (crack length/steel coil length, where each coil produced is about 32 m long) on the surface of the thin slab decreases from 0.056% to 0.031%, and the surface quality of the thin slab significantly improves.
Parametric Study of Vanadium Extraction Process from Refining Tailings of Crude Titanium Tetrachloride
Authors: Du Weitong , Yao Tingfeng , Cheng Haiming , Ju Dianchun , Chen Zhuo
Published: August 2024

The recovery of vanadium from titanium tetrachloride tail residue is a resource-efficient and environment-friendly method for treating hazardous vanadium-containing solid waste. In this study, to maximize the recovery rate of vanadium in the vanadium extraction process, the independent calcination and leaching factors were optimized using response surface methodology, in terms of calcination temperature (750–950 °C), calcination time (60–180 min), leaching liquid–solid ratio (5–25 mL/g), and leaching time (30–150 min). The results revealed that the calcination temperature was the most effective parameter for vanadium recovery, while the liquid–solid ratio was the least effective factor. Additionally, the optimal conditions were identified as a calcination temperature of 937 °C, a calcination time of 150 min, a leaching solid-to-liquid ratio of 17.4 mL/g, and a leaching time of 150 min. The maximum predicted recovery rate of vanadium by the model regression equation reached 93.1% and showed high credibility consistent with the experimental recovery rate of 93%.
Molecular Dynamics Study on the Mechanical Behaviors of Nanotwinned Titanium
Authors: Wu Bingxin , Jin Kaikai , Yao Yin
Published: August 2024

Titanium and titanium alloys have been widely applied in the manufacture of aircraft engines and aircraft skins, the mechanical properties of which have a crucial influence on the safety and lifespan of aircrafts. Based on nanotwinned titanium models with different twin boundary spacings, the impacts of different loadings and twin boundary spacings on the plastic deformation of titanium were studied in this paper. It was found that due to the different contained twin boundaries, the different types of nanotwinned titanium possessed different dislocation nucleation abilities on the twin boundaries, different types of dislocation–twin interactions occurred, and significant differences were observed in the mechanical properties and plastic deformation mechanisms. For the {101-2} twin, basal plane dislocations were likely to nucleate on the twin boundary. The plastic deformation mechanism of the material under tensile loading was dominated by partial dislocation slip on the basal plane and face-centered cubic phase transitions, and the yield strength of the titanium increased with decreasing twin boundary spacing. However, under compression loading, the plastic deformation mechanism of the material was dominated by a combination of partial dislocation slip on the basal plane and twin boundary migration. For the {101-1} twin under tensile loading, the plastic deformation mechanism of the material was dominated by partial dislocation slip on the basal plane and crack nucleation and propagation, while under compression loading, the plastic deformation mechanism of the material was dominated by partial dislocation slip on the basal plane and twin boundary migration. For the {1124} twin, the interaction of its twin boundary and dislocation could produce secondary twins. Under tensile loading, the plastic deformation mechanism of the material was dominated by dislocation–twin and twin–twin interactions, while under compression loading, the plastic deformation mechanism of the material was dominated by partial dislocation slip on the basal plane, and the product of the dislocation–twin interactions was basal dislocation. All these results are of guiding value for the optimal design of microstructures in titanium, which should be helpful for achieving strong and tough metallic materials for aircraft manufacturing.
Extreme Convective Gusts in the Contiguous USA
Authors: Cook Nicholas John
Published: August 2024

Most damage to buildings across the contiguous United States of America (USA) is caused by gusts in convective events associated with thunderstorms. Design rules for structures to resist these events rely on the integrity of meteorological observations and the methods of assessment. These issues were addressed for the US Automated Surface Observation System (ASOS) in six preliminary studies published in 2022 and 2023, allowing this present study to focus on the analysis and reporting of gust events observed between 2000 and 2023 at 642 well-exposed ASOS stations distributed across the contiguous USA. It has been recently recognized that the response of buildings to convective gusts, which are non-stationary transient events, differs in character from the response to the locally stationary atmospheric boundary gusts, requiring gust events to be classified and assessed by type. This study sorts the mixture of all observed gust events exceeding 20 kn, but excluding contributions from hurricanes and tropical storms, into five classes of valid meteorological types and two classes of invalid artefacts. The valid classes are individually fitted to optimal sub-asymptotic models through extreme value analysis. Classes are recombined into a joint mixture model and compared with current design rules.
Fabrication of Porous Collagen Scaffolds Containing Embedded Channels with Collagen Membrane Linings
Authors: Fakhri Neda , Khalili Arezoo , Sachlos Terry , Rezai Pouya
Published: August 2024

Tissues and organs contain an extracellular matrix (ECM). In the case of blood vessels, endothelium cells are anchored to a specialized basement membrane (BM) embedded inside the interstitial matrix (IM). We introduce a multi-structural collagen-based scaffold with embedded microchannels that mimics in vivo structures within vessels. Our scaffold consists of two parts, each containing two collagen layers, i.e., a 3D porous collagen layer analogous to IM lined with a thin 2D collagen film resembling the BM. Enclosed microchannels were fabricated using contact microprinting. Microchannel test structures with different sizes ranging from 300 to 800 µm were examined for their fabrication reproducibility. The heights and perimeters of the fabricated microchannels were ~20% less than their corresponding values in the replication PDMS mold; however, microchannel widths were significantly closer to their replica dimensions. The stiffness, permeability, and pore size properties of the 2D and 3D collagen layers were measured. The permeability of the 2D collagen film was negligible, making it suitable for mimicking the BM of large blood vessels. A leakage test at various volumetric flow rates applied to the microchannels showed no discharge, thereby verifying the reliability of the proposed integrated 2D/3D collagen parts and the contact printing method used for bonding them in the scaffold. In the future, multi-cell culturing will be performed within the 3D porous collagen and against the 2D membrane inside the microchannel, hence preparing this scaffold for studying a variety of blood vessel–tissue interfaces. Also, thicker collagen scaffold tissues will be fabricated by stacking several layers of the proposed scaffold.
Salmonirosea aquatica gen. nov., sp. nov., a Novel Genus within the Family Spirosomaceae, Was Isolated from Brackish Water in the Republic of Korea
Authors: Baek Kiwoon , Jang Sumin , Goh Jaeduk , Choi Ahyoung
Published: August 2024

A Gram-stain-negative, obligately aerobic, non-motile, rod-shaped bacterial strain designated SJW1-29T was isolated from brackish water samples collected from the Seomjin River, Republic of Korea. The purpose of this study was to characterize strain SJW1-29T and determine its taxonomic position as a potential new genus within the family Spirosomaceae. The strain grew within the range of 10–30 °C (optimum, 25 °C), pH 5.0–10.0 (optimum, 7.0), and 1–4% NaCl (optimum, 3%). Phylogenetic analysis based on the 16S rRNA gene revealed that strain SJW1-29T belongs to the family Spirosomaceae and is closely related to Persicitalea jodogahamensis Shu-9-SY12-35CT (91.3% similarity), Rhabdobacter roseus R491T (90.6%), and Arundinibacter roseus DMA-K-7aT (90.0%), while the similarities to strains within the order Cytophagales were lower than 90.0%. The genome is 7.1 Mbp with a G+C content of 50.7 mol%. The use of genome-relatedness indices confirmed that this strain belongs to a new genus. The major polar lipid profile consisted of phosphatidylethanolamine, and MK-7 was the predominant menaquinone. The predominant fatty acids were summed feature 3 (C16:1 ω7c and/or C16:1 ω6c), iso-C15:0, iso-C17:0 3-OH, and C16:0, representing more than 80% of the total fatty acids. The phenotypic, chemotaxonomic, genetic, and phylogenetic properties suggest that strain SJW1-29T represents a novel species within a new genus in the family Spirosomaceae, for which the name Salmonirosea aquatica gen. nov., sp. nov., is proposed. The type strain of Salmonirosea aquatica is SJW1-29T (=KCTC 72493T = NBRC 114061T = FBCC-B16924T).