bluuebunny/crossref_metadata_2025 huggingface dataset:
Current status of the congenital hypothyroidism neonatal screening program in Adana Province, Turkey
Authors: Kor Yılmaz , Kor Deniz
Published: May 2018

Background:

Congenital hypothyroidism (CH) is a common cause of mental retardation; it has a worldwide incidence ranging from 1:3000 to 1:4500 live births. Predictably, an increase in the reported incidence of primary CH occurs when the cut-off levels of thyroid-stimulating hormone are lowered. We aimed to evaluate the results of a congenital hypothyroidism screening program and current status in this study.

Methods:

Analysis results of 1300 infants who were referred to the endocrinology polyclinic because of suspected CH within the scope of the Ministry of Health National Neonatal Screening Program were retrospectively evaluated.

Results:

The diagnosis of CH and initiation of treatment were both done in 223 (18.5%) and 10 (0.8%) infants as a result of the initial evaluation and follow-up, respectively. The mean capillary and venous thyroid-stimulating hormone (TSH) levels of 223 patients were 40.78 (5.5–100) μIU/mL and 67.26 (10.7–100) μIU/mL, respectively. These patients’ mean heel prick time was 8.65 (0–30, median: 7) days. The mean age of the 223 infants whose treatment was initiated as a result of the initial evaluation was 19.87 (4–51, median: 20) days, and the mean age of the infants whose treatment was started at follow-up was 43.71 (29–65) days. The duration between heel prick time and venous TSH time was 11.10 (2–28, median: 11) days and was longer than planned (3–5 days).

Conclusions:

Although the duration for the diagnosis and initiation of CH treatment were markedly reduced with the implementation of the screening program in Turkey compared to those before the implementation of the screening program, we have not yet achieved the ideal time (≤14 days).
Cardiac examination in children with Laron syndrome undergoing mecasermin therapy
Authors: Erol Nurdan , Yıldız Metin , Güven Ayla , Yıldırım Ayse
Published: May 2018

Background:

Laron syndrome (LS), which can be defined as primary growth hormone resistance or insensitivity, is a rare genetic disease inherited by an autosomal recessive trait. Although it is undistinguishable from growth hormone deficiency, LS has high levels of growth hormone, but insulin-like growth factor (IGF-1) cannot be synthesized. Mecasermin treatment is the only option for the patients who suffer from LS. This study aims to research cardiac findings of children with LS, who receive treatment with mecasermin.

Methods:

The study enrolled five children four males and one female, 4 M/1 F with LS, two of whom were siblings with a mean age of 6.3±2.1 years, a body weight of 13.36±4.74 kg, a height of 88±8.7 cm, and a body mass index (BMI) of 16.47±3.35. Their demographic data were obtained from their family and files. The children received mecasermin via subcutaneous injection at 0.04–0.12 μg/kg doses twice per day. The duration of mecasermin treatment was 8–53 months. All of them were examined clinically by electrocardiogram and echocardiogram.

Results:

Their cardiac examinations were normal, except for one case, who had systolic murmur at cardiac auscultation. Arrhythmia was not observed on their electrocardiograms. The echocardiograms did not show a significant congenital cardiac anomaly. Their cardiac measure and functions were within normal ranges. The echocardiogram of the child with the murmur showed mitral and tricuspid insufficiency. The Doppler images showed pulmonary hypertension findings. These findings were proven by angiography. The vasoreactivity test results of that patient were negative. No reason could be found for the observed pulmonary hypertension. We diagnosed this finding as a primary pulmonary hypertension and Bosentan therapy was started.

Conclusions:

In this study, we showed that cardiac findings were consistent with previous studies. To the best of our knowledge, the observed pulmonary hypertension in children with LS, who received treatment with or without mecasermin, is reported for first time in the literature.
Predictors of bone maturation, growth rate and adult height in children with central precocious puberty treated with depot leuprolide acetate
Authors: Klein Karen O. , Dragnic Sanja , Soliman Ahmed M. , Bacher Peter
Published: May 2018

Background:

Children with central precocious puberty (CPP) are treated with gonadotropin-releasing hormone agonists (GnRHa) to suppress puberty. Optimizing treatment outcomes continues to be studied. The relationships between growth, rate of bone maturation (bone age/chronological age [ΔBA/ΔCA]), luteinizing hormone (LH), predicted adult stature (PAS), as well as variables influencing these outcomes, were studied in children treated with depot leuprolide (LA Depot)

Methods:

Subjects (64 girls, seven boys) with CPP received LA Depot every 3 months for up to 42 months. Multivariate regression analyses were conducted to examine the predictors affecting ΔBA/ΔCA, PAS and growth rate.

Results:

Ninety percent of subjects (18 of 20) were suppressed (LH levels <4 IU/L) at 42 months. Over 42 months, the mean growth rate declined 2 cm/year, the mean BA/CA ratio decreased 0.21 and PAS increased 8.90 cm for girls (n=64). PAS improved to mid-parental height (MPH) in 46.2% of children by 30 months of treatment. Regression analysis showed that only the Body Mass Index Standardized Score (BMI SDS) was significantly associated (β+0.378 and +0.367, p≤0.05) with growth rate. For PAS, significant correlations were with MPH (β+0.808 and +0.791, p<0.001) and ΔBA/ΔCA (β+0.808 and +0.791, p<0.001). For ΔBA/ΔCA, a significant association was found only with BA at onset of treatment (β−0.098 and −0.103, p≤0.05). Peak-stimulated or basal LH showed no significant influence on growth rate, ΔBA/ΔCA or PAS.

Conclusions:

Growth rate and bone maturation rate normalized on treatment with LA Depot. LH levels were not significantly correlated with growth rate, ΔBA/ΔCA or PAS, suggesting that suppression was adequate and variations in gonadotropin levels were below the threshold affecting outcomes.
Metabolic risk factors in adolescent girls with type 1 diabetes
Authors: Castro-Correia Cíntia , Santos-Silva Rita , Pinheiro Marta , Costa Carla , Fontoura Manuel
Published: May 2018

Background:

The incidence of pediatric metabolic syndrome (MS) has progressively increased. The incidence of type 1 diabetes mellitus (T1DM) has also increased. Thus, some children and adolescents with T1DM exhibit MS parameters. The aim of the study was to evaluate the presence of MS parameters in female adolescents with T1DM based on their nutritional status.

Methods:

We evaluated 44 adolescents with T1DM (consecutive non-randomized sample) aged between 14 and 18 years, who were on intensive therapy with insulin. Patients were subdivided according to their body mass index (BMI). Variables evaluated include: age, age at diagnosis, weight, height, BMI, abdominal circumference, blood pressure, glycated hemoglobin (HbA1c), abdominal and pelvic ultrasound and lipoprotein profile. Gynecological history data were also collected.

Results:

Lipid profile changes were identified in 32% of overweight or obese girls and in 23% of those with an adequate weight. Hypertension (HT) was observed in 19% of overweight or obese girls and in 14% of those with a BMI≥85th percentile (Pc). The only statistically significant difference between the groups was the presence of abdominal adiposity. All other features, including the presence of dyslipidemia, HT, abdominal adiposity, non-alcoholic steatohepatitis (NASH) and polycystic ovarian syndrome (PCOS), were present in both groups.

Conclusions:

Although being overweight and/or obese aggravates the risk of cardiovascular disease, MS is already present in many young adolescents with T1DM of normal weight. It is necessary that MS risk factors are routinely evaluated in all diabetic adolescents, including those with an adequate BMI.
Oscillation and non-oscillation of half-linear differential equations with coeffcients determined by functions having mean values
Authors: Hasil Petr , Veselý Michal
Published: May 2018

The paper belongs to the qualitative theory of half-linear equations which are located between linear and non-linear equations and, at the same time, between ordinary and partial differential equations. We analyse the oscillation and non-oscillation of second-order half-linear differential equations whose coefficients are given by the products of functions having mean values and power functions. We prove that the studied very general equations are conditionally oscillatory. In addition, we find the critical oscillation constant.
MAPK pathway involved in epidermal terminal differentiation of normal human epidermal keratinocytes
Authors: Meng Xianguang , Qiu Liyun , Song Haiyan , Dang Ningning
Published: May 2018

Objective

To investigate the effect of mitogen-activated protein kinase (MAPK) signaling pathway in epidermal terminal differentiation.

Methods

The MAPK pathways (p38, ERK1/2, JNK) were inhibited by SB203580, PD98059, and SP600125 in normal human epidermal keratinocytes (NHEKs), respectively. Western blotting assays were performed to detect expression of filaggrin and differentiation-related proteins. The mRNA expressions of differentiation-related proteins were detected by real-time quantitative PCR (qRT-PCR).

Results

Inhibition of MAPK pathway by SB203580, PD98059, and SP600125 resulted in significant reduction of filaggrin expression in NHEKs. Inhibition of the p38 MAPK pathway decreased the expression of differentiation-related proteins (cytokeratin 5, cytokeratin 14, ST14, and SPRR3), Akt, and NF-κB. Inhibition of JNK also suppressed expression of cytokeratin 14, SPRR3, Akt, and NF-κB. However, inhibition of ERK1/2 merely decreased expression of SPRR3 and Akt.

Conclusion

MAPK pathways regulates epidermal terminal differentiation in NHEKs. The p38 signaling pathway plays an especially important role.
Association of central obesity with sex hormonebinding globulin: a cross-sectional study of 1166 Chinese men
Authors: Liu Fangwei , Shen Xubo , Wang Ruifeng , Yu Na , Shi Yongjun , Xiong Shimin , Xiong Chengliang , Zhou Yuanzhong
Published: May 2018

Background Both sex hormone-binding globulin and central obesity have been found to be associated with metabolic and cardiovascular diseases. However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated.

Methodology We performed a cross-sectional study of 1166 male participants from Zunyi, Guizhou, western China, in 2013. Each participant completed a questionnaire and had a brief clinical exam with a fasting blood sample taken. All blood samples underwent standard laboratory testing for sex hormone-binding globulin. Level of serum sex hormone-binding globulin was compared by demographic characteristics, and multiple linear regression was used to evaluate the independent association of variables and sex hormone-binding globulin level.

Results The mean serum level of sex hormone-binding globulin was increased in old-aged men (older than 40 years; mean 44.68±20.58 nmol/L), low diastolic blood pressure (<90mmHg; 43.76±20.50 nmol/L), waist-to-height ratio <0.5 (48.73±20.59 nmol/L), no education (52.36±22.91 nmol/L), farm occupation (43.58±20.60nmol/L), non-alcohol or former user (44.78±20.94 nmol/L) and long-term medication history (44.79±21.50 nmol/L). Factors independently associated with sex hormone binding globulin level on multiple regression were waist-to-height ratio (β=- 11.84 [95% confidence interval -13.96,-9.72]), age(β=12.40 [9.63,15.17]) and diastolic blood pressure (β=-5.07 [-7.44,-2.71]).

Conclusions Central obesity has an independent inverse relation with serum level of sex hormone binding globulin among western Chinese men
Transition metal-catalyzed dehydrogenation of amines
Authors: Broere Daniël L. J.
Published: May 2018

This review focuses on the use of homogeneous transition metal complexes for the catalytic dehydrogenation of amines for synthetic purposes, and for hydrogen storage applications. The catalytic dehydrogenation of primary, secondary and cyclic amines is reviewed looking at reaction conditions, different catalysts and common side reactions. Recent developments in this active field of research showcase how cooperative ligands and photocatalysts can overcome the need for noble metals or harsh reaction conditions.
Prevention-intervention strategies to reduce exposure to e-waste
Authors: Heacock Michelle , Trottier Brittany , Adhikary Sharad , Asante Kwadwo Ansong , Basu Nil , Brune Marie-Noel , Caravanos Jack , Carpenter David , Cazabon Danielle , Chakraborty Paromita , Chen Aimin , Barriga Fernando Diaz , Ericson Bret , Fobil Julius , Haryanto Budi , Huo Xia , Joshi T.K. , Landrigan Philip , Lopez Adeline , Magalini Frederico , Navasumrit Panida , Pascale Antonio , Sambandam Sankar , Aslia Kamil Upik Sitti , Sly Leith , Sly Peter , Suk Ann , Suraweera Inoka , Tamin Ridwan , Vicario Elena , Suk William
Published: May 2018

As one of the largest waste streams, electronic waste (e-waste) production continues to grow in response to global demand for consumer electronics. This waste is often shipped to developing countries where it is disassembled and recycled. In many cases, e-waste recycling activities are conducted in informal settings with very few controls or protections in place for workers. These activities involve exposure to hazardous substances such as cadmium, lead, and brominated flame retardants and are frequently performed by women and children. Although recycling practices and exposures vary by scale and geographic region, we present case studies of e-waste recycling scenarios and intervention approaches to reduce or prevent exposures to the hazardous substances in e-waste that may be broadly applicable to diverse situations. Drawing on parallels identified in these cases, we discuss the future prevention and intervention strategies that recognize the difficult economic realities of informal e-waste recycling.
The endocrinology of male breast cancer
Authors: Fentiman Ian S
Published: May 2018

Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E2) levels from hepatic conversion of androgen. Klinefelter’s syndrome (XXY) is associated with a 50-fold increase in incidence of MBC compared with XY males, and this is the most pronounced evidence for testicular malfunction amplifying risk. Delay in presentation means that up to 40% of cases have stage III or stage IV disease at diagnosis. No randomised controlled trials have been reported on endocrine treatment of advanced disease or adjuvant/neoadjuvant therapy following or preceding surgery. Tamoxifen is the most effective endocrine therapy, but side effects can lead to non-compliance in a substantial number of men. Aromatase inhibitors are less effective because they do not inhibit testicular oestrogen production. There is an urgent need for collaborative trials to provide an evidence base for the most effective endocrine and least toxic therapies for men with breast cancer.
Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression
Authors: Yang Qingling , Dai Shanjun , Luo Xiaoyan , Zhu Jing , Li Fangyuan , Liu Jinhao , Yao Guidong , Sun Yingpu
Published: May 2018

The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration as a result of the aging process. Melatonin is considered to be an anti-aging agent. However, the underlying mechanisms of how melatonin improves the quality of postovulatory aged oocytes remain largely unclear. In this study, by using mouse model, we found that there were elevated reactive oxygen species levels and impaired mitochondrial function demonstrated by reduced mitochondrial membrane potential and increased mitochondrial aggregation in oocytes aged 24 h, accompanied by an increased number of meiotic errors, unregulated autophagy-related proteins and early apoptosis, which led to decreased oocyte quality and disrupted developmental competence. However, all of these events can be largely prevented by supplementing the oocyte culture medium with 10−3 M melatonin. Additionally, we found that the expression of sirtuin family members (SIRT1, 2 and 3) was dramatically reduced in aged oocytes. In addition,in vitrosupplementation with melatonin significantly upregulated the expression of SIRT1 and antioxidant enzyme MnSOD, but this action was not observed for SIRT2 and SIRT3. Furthermore, the protective effect of melatonin on the delay of oocyte aging vanished when the SIRT1 inhibitor EX527 was used to simultaneously treat the oocytes with melatonin. Consistent with this finding, we found that the postovulatory oocyte aging process was markedly attenuated when the oocytes were treated with the SIRT1 activator SRT1720. In conclusion, our data strongly indicate that melatonin delays postovulatory mouse oocyte aging via a SIRT1–MnSOD-dependent pathway, which may provide a molecular mechanism support for the further application of melatonin in the assisted reproductive technology field.
An Association Mapping Framework To Account for Potential Sex Difference in Genetic Architectures
Authors: Kang Eun Yong , Lee Cue Hyunkyu , Furlotte Nicholas A , Joo Jong Wha J , Kostem Emrah , Zaitlen Noah , Eskin Eleazar , Han Buhm
Published: May 2018

Recent genome-wide association studies suggest that the human genetic architecture of complex traits may vary between males and females; however, traditional approaches for association mapping cannot fully account for these between-sex differences...

Over the past few years, genome-wide association studies have identified many trait-associated loci that have different effects on females and males, which increased attention to the genetic architecture differences between the sexes. The between-sex differences in genetic architectures can cause a variety of phenomena such as differences in the effect sizes at trait-associated loci, differences in the magnitudes of polygenic background effects, and differences in the phenotypic variances. However, current association testing approaches for dealing with sex, such as including sex as a covariate, cannot fully account for these phenomena and can be suboptimal in statistical power. We present a novel association mapping framework, MetaSex, that can comprehensively account for the genetic architecture differences between the sexes. Through simulations and applications to real data, we show that our framework has superior performance than previous approaches in association mapping.
Recent occurrence of Tinamus solitarius (Vieillot, 1819) (Tinamiformes, Tinamidae) in central Rio Grande do Sul state, southern Brazil
Authors: Brondani Ivan Luiz , Behr Everton Rodolfo , Damasceno Veronica Pereira , Krügel Marilise Mendonça
Published: May 2018

Tinamus solitarius (Vieillot, 1819), the Solitary Tinamou, was observed in the central region of Rio Grande do Sul state, on the western portion of the Serra Geral escarpment, in the municipality of Itaara. This population is the most austral of the species and is isolated from the 2 other populations that inhabit Rio Grande do Sul: 1 in Turvo State Park and the other in the eastern portion of the Serra Geral escarpment.
ENDOVASCULAR TREATMENT OF THE RESIDUAL THROMBOEMBOLIC PULMONARY HYPERTENSION AFTER PULMONARY THROMBENDARTERECTOMY WITH THE DENERVATION SYSTEM SYMPLICITY
Authors: Rudenko B. A. , Feshchenko D. A. , Shanoian A. S. , Drapkina О. М. , Gavrilova N. Е. , Beregovskaya S. A. , Akhadova А. Sh. , Shukurov F. B. , Vlasov V. Yu. , Zhavoronkova E. A. , Boytsov S. A. , Dzemeshkevich S. L. , Koltunov A. N. , Edemsky A. G.
Published: May 2018

Aim. To assess the safety and efficacy of radiofrequency denervation of pulmonary artery (PA) with the Simplicity system in patients with residual pulmonary hypertension (PH) after the thromberarterectomy surgery.

Material and methods. To the study, 12 patients included, with the signs of residual PH (by echocardiography data, mean PH pressure ≥25 mmHg), who had undergone surgery (thrombendarcterectomy) for chronic thromboembolic PH. Mean time interval between the diagnosis of PH and pulmonary denervation was 8,5 years. After catheterization of the right chambers of the heart and tensiometry in small circle circulation, the spot circular radiofrequency denervation performed of the right and left PH at the area of ostia, with ablation catheter Simplicity. The success was defined by decrease of mean PA pressure >10 mmHg, absence of complications, exercise tolerance increase after the procedure immediately and in 12 months.

Results. At long term period after the intervention there was significant decrease of mean PA pressure from 58±6 to 33±4 mmHg (p<0,01), of pulmonary vascular pressure from 8,6±2,1 to 3,2±1,4 mmHg (p<0,01) and increase of exercise tolerance from 321±19 m to 487±29 m (p<0,01). During the follow up period, 1 patient died in 8 months after inclusion due to severe gastrointestinal bleeding. The rest did not present with adverse events or non­planned hospitalizations. Nine patients noted significant improvement of general health, decrease of dyspnea and fatigue, 3 patients had discontinued sildenafil. There were no complications at PA radiofrequency ablation procedure (death, arrhythmias, PA perforation, acute PA thrombosis in the place of access, bleeding).

Conclusion. Utilization of the Simplicity system in PA denervation is safe and effective. Further randomized studies in need to confirm clinical benefits from the procedures in PH patients.
Structural and Physical Properties of the PbS Films Obtained by Chemical Bath Deposition at Different Deposition Temperature
Authors: KIYAK YILDIRIM Ayça , ALTIOKKA Barış
Published: May 2018

In the present study, structural and physical
properties of the PbS thin films produced using chemical bath deposition method
were investigated.
Deposition temperature was varied between 25 °C and 50 °C throughout the deposition
period. The pH value of electrolyte solution and the deposition time of the
films were 10.5 and 25 min, respectively. Characterizations of the PbS thin films
were performed using scanning electron microscopy (SEM) and X-ray
diffraction (XRD) methods. XRD results showed
that all PbS thin films had a cubic structure irrespective of deposition
temperature. Morphological
characterizations of the films indicated that not only the number but also the
size of pinholes, formed on the film surfaces, were significantly affected by
the deposition temperature. Consequently,
the film obtained at 25 ̊C exhibited a surface morphology with less and smaller
pinholes, compared to others deposited at higher deposition temperatures.
Responding to Change and Looking to the Future in Temporal Turn
Authors: Jones Ryan
Published: May 2018

This review covers the five themes of Temporal Turn: Art and Speculation in Contemporary Asia, and suggests the greatest achievement of the exhibition, while also offering suggestions to improve its impact. The paper also delves into the rapid changes in Asia over the past 50 years, including political, cultural, and population transformation, tying them to specific works in the exhibition. The article selects artworks in Temporal Turn emphasizing these large, rapid changes made by contemporary Asian artists. Research into the economic, political, and cultural facets of East Asian culture is used to back claims made in the paper. Furthermore, the paper proposes how the viewer should respond to the exhibition with thematic context, suggesting it disorients its audience in time and reality.
Co-Production of Disability and Race
Authors: Bunton Zoe
Published: May 2018

Disability studies scholars have called for a critical refocusing of disability as not only an identity that intersects with race but also as an identity rooted in racialization. By reading the prison writings of Mumia Abu-Jamal across the grain as a disability text, the co-constitution of Blackness, disability, and criminalization is evident in not just disability studies scholarship, but also the lived experiences of Black, criminalized authors. By applying critical theoretical lenses of race and disability to works like Live from Death Row, one can better identify how the disenfranchisement of Black people is purported to be natural in American culture.
Shakespearanity
Authors: Fox Megan
Published: May 2018

Shakespeare’s immense cultural value can be seen by the numerous book, movie, and internet references to his work which populate modern society. However, this was not always the case: for hundreds of years Shakespeare remained the almost exclusive property of the aristocracy and academia. Scholars have noted how this perception of Shakespeare shifted during the Victorian era, but have not yet explored how this influences contemporary interactions with Shakespeare. This paper, through a case study on the third murderer of Macbeth, argues that the Victorian Era changed the way modern people conceptualize and interact with the playwright by beginning the legacy of engaging with Shakespeare as a pop culture icon.
(Ef)facing the Other
Authors: Burdge Alex
Published: May 2018

abstract
“Why Can’t I Find It?”
Authors: Fortmeyer Sophia
Published: May 2018

This research focuses on foreign intervention in the mining sectors of Zambia and the Democratic Republic of Congo (DRC), concentrating on the transparency of agreements and regulation, or lack thereof, contributing to the longevity of mining practices and the livelihoods of local citizens. The current state of public information regarding natural resource extraction in both countries creates questions about state motives and investors’ economic incentive, with consequences of inequality, human rights offenses, and underdevelopment. Applying Immanuel Wallerstein’s world-systems theory, I describe the economic rationale behind global involvement in the region’s mining operations and identify potential power imbalances. I use commodity statistics, state documentation, and nongovernmental reports to analyze reporting trends on mining operations. Intergovernmental databases with development statistics also contribute to the research. In this study, I argue foreign intervention in underdeveloped, mineral rich countries does not have to be a purely exploitative relationship as emphasized by Wallerstein’s theory, demonstrated through the implementation of international transparency initiatives. These programs, implemented for the benefit of the resource abundant countries like Zambia and the DRC, can increase the accountability of governments and investing companies related to mining activities. Complete reporting on natural resource extraction increases investment values and the development and productivity of the mining industry.
Doença Pulmonar Obstrutiva Crônica: atividade de vida diária e qualidade de vida
Authors: Silva Cássio Magalhães , Pinto Neto Abilio Costa , Nepomuceno Júnior Balbino Rival Ventura , Teixeira Helena Pereira , Saquetto Micheli Bernadone , Souza-Machado Adelmir
Published: May 2018

INTRODUÇÃO: A qualidade de vida (QV) é um instrumento relevante para o contexto funcional na doença pulmonar obstrutiva crônica (DPOC), a escala London Chest Activity of Daily Living (LCADL) avalia a atividade de vida diária (AVD) em pacientes com DPOC. OBJETIVO: avaliar a capacidade em realizar AVD e a QV dos pacientes com DPOC que buscam serviço público de reabilitação pulmonar (RP). MÉTODOS: Pesquisa transversal, realizada de 2014 até 2017, 27 pacientes diagnósticados DPOC leve a grave de acordo os critérios GOLD, de ambos os sexos, estáveis, sem exacerbações recentes. Foi utilizado ANOVA para analisar diferença entre as médias de LCADL e Saint George's Respiratory Questionnaire (SGRQ) em seguida o teste pos- HOC de Turkey para delimitar o impacto de cada preditor separadamente. Utilizou-se o teste de Spearmann para correlacionar LCADL e SGRQ. RESULTADOS: Encontrada limitação leve para todos os domínios da escala LCADL 22,7 ± 8,4 pontos com 30,2% de limitação. A QV é impactada em todos os domínios (31,2 ± 11,6 pontos) de forma moderada a grave com 41,6% de redução. A dispnéia e a fadiga interferem de forma correlata na AVD, r = 0,78 (p < 0,05). O escore LCADL correlaciona-se diretamente com a QV, r =0,59 (p < 0,05). CONCLUSÃO: Os pacientes apresentam limitação na atividade de vidade diária e impacto na qualidade de vida, além de forte correlação entre o índice de dispneia da escala LCADL e seus domínios.
Costs comparison in different supply processes of respiratory physiotherapy materials in an extra public hospital
Authors: Stipanich Cássio , Goulardins Juliana Barbosa , Medeiros Marion , Maria Francisca , Tanaka Clarice
Published: May 2018

INTRODUCTION: Every year millions of dollars are expended to equip and maintain the hospital sterilization centers in the world. Respiratory therapy materials are essential to life support, and have a major impact on clinical complications. To provide respiratory therapy materials with appropriate hygiene in a hospital is a challenge for manager due to clinical and costs impact. OBJECTIVE: To compare costs of different methods of providing respiratory therapy materials in a general, extra, tertiary and public hospital. METHODS: It consisted of an observational study, based on document review and critical analysis of hospital management indicators, and analyzed materials used in respiratory therapy, classified as semi-critical products, including manual resuscitator, nebulizer, kit for Continuous Positive Airway Pressure (CPAP), ventilatory circuit for non-invasive and invasive mechanical ventilation. RESULTS: Compared to the supply process of disposable materials acquisition, the supply process in the Institutional Central Sterilization Supply Department generates an annual savings with values calculated at US$ 289,679.26; while compared to the Outsourced Central Sterilization Supply Department the supply process in the Institutional Central Sterilization Supply Department saves an amount of US$ 257,041.11 annually. CONCLUSION: This was the first Brazilian study to conduct a cost analysis in this context. The supply process with the cleaning of respiratory physiotherapy materials in the Institutional Central Sterilization Supply Department was more advantageous with lower costs when compared to the Outsourced Central Sterilization Supply Department or cost of acquisition of disposable materials. The annual savings estimated considering the average monthly consumption in this study exceeded US $ 250,000.00. Detailed cost analysis provides crucial information and can enable better financial management.
COMO CANDIDATOS AO CURSO DE PSICOLOGIA PERCEBEM A PROFISSÃO ESCOLHIDA?
Authors: Daltro Mônica Ramos , Pondé Milena Pereira
Published: May 2018

Esse artigo é parte de uma tese de doutoramento que investiga a dimensão subjetiva presente na formação em psicologia, esta etapa da pesquisa investigou a percepções candidato aos cursos sobre a profissão escolhida. Estudo descritivo, aprovado pelo CEP, parecer nº 108.985 Analisa o conteúdo de 54 fichas contendo a percepção sobre a psicologia, durante vestibular, de uma instituição privada, em Salvador-Bahia. Os resultados confirmam a literatura sobre a percepção da psicologia como profissão de ajuda. O sentido desta ajuda foi analisado e decorreram núcleos de sentido para a ação de ajudar: curativo, orientadora e mediadora. Constata-se que psicologia é percebida como plural, mas a partir de valores próprios da modernidade, fundamentados em um modelo de subjetividade de natureza binária que tende a responder às demandas do discurso biomédico e neoliberal hegemônicos na contemporaneidade
CUIDADO MULTIPROFISSIONAL PARA O PACIENTE TERMINAL NA UTI: UMA REVISÃO SISTEMÁTICA
Authors: Gouveia Thyara Batalha de Matos , Aleluia Ieda Maria Barbosa
Published: May 2018

INTRODUÇÃO: A morte faz parte do ciclo vital e é um equívoco achar que o limite do cuidado é compatível com o limite terapêutico. No ambiente de unidade de terapia intensiva onde dispomos de diversas tecnologias para melhorar o estado funcional e até salvar a vida do paciente é necessário estabelecer os limites entre qualidade de vida e extensão da vida. A medicina paliativa surge neste ambiente com o objetivo de atender as demandas de todas as dimensões do cuidado ao paciente e a família, sendo este o papel da equipe multiprofissional. OBJETIVO: Avaliar o papel da equipe multiprofissional no cuidado do paciente terminal. METODOLOGIA: Trata-se de uma revisão sistemática. As buscas dos artigos foram realizados no PubMed, na Biblioteca Virtual em Saúde (BVS) e na Scientific Eletronic Library Online Brazil (Scielo). Inicialmente foram lidos os títulos os artigos, depois os resumos e posteriormente a seleção foi a leitura na íntegra. Os artigos que foram selecionados foram aplicados de acordo com o critério PRISMA e o somatório da pontuação deveria ser maior que 70% dos itens para fazer parte do estudo. RESULTADOS: Foram encontrados 864 artigos, que após a leitura do título foram lidos 64 resumos, lidos na íntegra 29 artigos, foram para análise do prisma 12 e foram incluídos no artigo 9. Destes 2 eram revisões de literatura, 2 estudos multicêntricos, 1 pesquisa exploratório-descritiva, 1 estudo quanti-qualitativo, 1 estudo descritivo, 1 estudo de corte-transversal e 1 estudo randomizado CONCLUSÃO: A unidade de terapia intensiva é o ambiente onde a equipe multiprofissional é mais alinhada, porém quando o tema é cuidados paliativos a literatura demonstra que não ocorre de forma tão sincrônica. Os cuidados paliativos merecem maior atenção para que a morte seja conduzida de forma tranquila e digna.Palavras-chave: Cuidado multiprofissional; Unidade de terapia intensiva; Cuidados paliativos; Paciente terminal; UTI.
INFLUENCE OF TRAINING POLICIES IN THE COLLECTIVE HEALTH STAGE: THE EXPERIENCE IN A UNIVERSITY
Authors: Vieira Danmires de Mendonça , Balbino Elisa Maria Santos , De Carvalho Dayane Silva , Farias Jéssika Bertoldo Costa , Lima Bárbara Patrícia da Silva
Published: May 2018

Introduction: The Unified Health System (SUS, in portuguese) presents, among its functions, the ordering of the training of human resources in the health area in the country. In order to systematize this, the National Curricular Guidelines (DCN) of the undergraduate health courses were instituted. Soon, the Institutions of Higher Education (IES) were instructed to train professionals to work in the SUS. Thus, it was advised that these courses developed activities focused on the field of collective health, focused mainly on Primary Health Care (APS). Objectives: To report on the experience of an interprofessional work experience in the Integrated Stage in Collective Health in a public IES in the state of Alagoas; To reflect on how training policies are being put into practice. Methods: 33 field diaries were analyzed by trainees. The internship had a workload of 4 hours per week, in which activities were planned, supervised and developed in an integrated way. Results: The internship took place in a Family Health Unit and Social Assistance Reference Center, with students from Speech Therapy and Occupational Therapy. This period was initially marked by difficulties of interaction among the trainees, both in communication and in the elaboration of resources, but it was noticed that this is inherent in teamwork. The trainees acknowledged that the IES attends the DCN, contributing positively to its formation. Conclusion: It is important to maintain policies for training in APS, not only the Speech-Language Pathologist, because the interprofessional practice based on the DCN and the Organic Law of SUS provides a formation that pervades the individual sphere.
SILENCE IS GOLDEN: PUTTING YOURSELF IN THE PATIENTS’ SHOES
Authors: Soares Queiroz Alessandra , De Abreu Porciúncula Bruna , Ramos Baeta Neves Marina , Carneiro de Freitas Natália , Vieiralves João Izzo Pinto Rafaela , Zaidhaft Sergio
Published: May 2018

In order to develop empathy for patients and to have a better understanding of theirlimitations and difficulties of compliance to prescriptions and proscriptions, theDoctor-Patient Relationship discipline of a Brazilian medical school asks itsstudents to feel, for a certain time, the restrictions imposed by some disease orcondition.Five female students, self-defined as extremely talkative, remained silent for two days. An individual report was made, and the experience of all was checked in regards to: the motivation and the expectations for the work; the reaction of relatives, teachers and colleagues; the feelings and reflections provided by the experience.
O paradigma científico no discurso da mídia brasileira sobre Zika e microcefalia
Authors: Santos Juliane Lopes Ferreira dos , Matias Denise Silva , Novais Nauana Nascimento
Published: May 2018

Introdução: Em 2015 o Brasil foi surpreendido por um aumento da incidência de microcefalia, relacionada pelo Ministério da Saúde à infecção pelo vírus Zika durante a gestação. Este tema, de grande notoriedade para a saúde pública, alcançou ampla repercussão popular através da mídia. Objetivos: Descrever a presença do paradigma científico no discurso de profissionais de saúde, pesquisadores ou jornalistas que informam ao público leigo a respeito de causalidade biológica. Metodologia: Foi realizado o levantamento de todas as notícias disponibilizadas na plataforma digital do jornal Folha de São Paulo, contendo o termo chave "Zika e microcefalia" e publicadas entre 11 de novembro de 2015 a 04 de março de 2016, período em que havia pouca elucidação científica sobre o assunto. As notícias foram classificadas quanto à presença da certeza ou incerteza sobre a relação entre Zika e microcefalia em seu conteúdo e quanto à ideia central nos títulos das matérias. Resultados: Das 387 notícias analisadas, 51,4% relacionaram o Zika como fator causal da microcefalia, enquanto 32,8% consideraram a presença da incerteza na relação. Constatou-se que o jornal privilegiou temas relacionados às repercussões decorrentes das doenças, predominando o relato de medidas de controle. Considerando-se a origem das notícias, foi significativo o uso de fontes oficiais, apresentadas em 82% das notícias. Conclusão: O paradigma científico foi desconsiderado, ignorando-se o princípio da incerteza e o debate científico. Também foram evidenciadas limitações dos jornalistas e gestores de saúde na elaboração de uma comunicação eficaz com a população em situação de emergência de saúde pública.
Endotoxication indicators in the blood of patients with ischemic stroke complicated by type two diabetes mellitus
Authors: Tsarenko T. , Gayda L. , Kravchenko O.
Published: May 2018

Diabetes is one of the generally accepted factors of acute cerebral blood flow disorders. Numerous studies have shown involvement of many factors in the pathogenesis of diabetic cerebral disorders, the most important of which are the metabolic changes, including endotoxication. The aim of this study was to measure the endotoxication parameters and total protein and albumin contents in the blood of patients with ischemic stroke and patients with stroke complicated by type 2 diabetes. Also the average sex, age of the patients, body mass index (BMI) and blood glucose and lipoproteins levels, different disease complication presents and NIH Stroke Scale with Barthel index were determined. The investigation had shown that patients with ischemic stroke, including complicated by insulin independent diabetes, were characterized by hypoproteinemia with the absence of marked changes of albumin content. The middle mass molecule (MSM) and oligopeptide contents revealed the presence of endogenous intoxication. These parameters, exceeding the control by 1.5 times, were high independently of hyperglycemia presence.
The results also allowed to establish differences in BMI, hyperlipoproteinemia and increasing of NIHSS in patients with ischemic stroke and diabetes mellitus type 2 comparing with stroke alone. Thus, the development of ischemic stroke separately and under conditions of type II diabetes was characterized by increasing rates of endotoxication (middle mass molecule and oligopeptides contents) in the blood of patients, that with hypoproteinemia and hyperlipidemia may cause the secondary pathobiochemical changes in the head brain cells and mediate the negative effects of acute disorders of cerebral blood circulation.
Amino acids level in rats upon long-term administration of progesterone
Authors: Aleksandrov A. , Ishchuk T. , Skopenko O. , Konopelniuk V.
Published: May 2018

Amino acids levels in blood serum of rats under progesterone long-term administration have been determined. The studies show that levels of most amino acids content decrease in rats under progesterone long-term administration compared with control group of rats. Obtained data give evidence that progesterone long-term administration significantly influence on amino acids metabolism.
Specificity and Problems of Development of Gifted Children in Primary School Age
Authors: Shumakova N.B.
Published: May 2018

The article considers the features of intellectual and personal development of gifted children, problems that arise in the younger school age. The most common difficulties of the intellectually gifted first-graders, connected with the instruction in the school and the interrelations with their peers are pointed. The origins of these problems are clarified - the specifics of development in preschool childhood, and not quite adequate conditions of family upbringing and education. The value of creative or research instruction for the gifted children is revealed. The experience of realization the special interdisciplinary curriculum “Gifted Child” for gifted children based on the principles of systematic, activity, value of creation, novelty, problem finding, multimodality, personal interest, dialogical and independence are analyzed. These basic principles of formation of education allow the child to maintain the research position and develop the creative potential.
Physical Parameters and Comfort of the School Environment in Assessments of Schoolchildren and Teachers
Authors: Ivanova E.V. , Nesterova O.V. , Vinogradova I.A.
Published: May 2018

The problem of interrelation of physical parameters of school space with the state of comfort of students and teachers in conditions of different types of educational environment is considered: "enriched", "standard" and "depleted". The hypothesis was that the assessment of comfort is interrelated with the physical parameters of the environment (temperature, air quality, illumination, acoustics, furniture) and has significant differences in the assessments of schoolchildren and teachers of schools with different types of educational environment. 416 schoolchildren and 73 teachers of three Moscow educational complexes took part in the study. Specially developed questionnaires were used. In the group of schoolchildren, significant differences in assessments of the comfort of the school space and its individual physical parameters were revealed depending on the type of educational environment and significant relationships were established between these indicators. The state of comfort of schoolchildren is determined by the type of educational environment and its physical parameters. For teachers, comfort, which is higher in comparison with the assessments of children, is determined by a favorable psychological climate and benevolent relationships.
Experience of «USPU» in Organization of School and University Partnerships in Training Teachers (Basic Professional Educational Program «Teacher of Primary General Education»)
Authors: Voronina L.V. , Byvsheva M.V.
Published: May 2018

The article presents the experience of participation of the Ural State Pedagogical University in the project «Implementation of the Competence Approach in the Development and Approbation of the Main Professional Educational Programs of Higher Education in the EGSD «Education and Pedagogical Sciences (Bachelor's, Master's and Postgraduate Education, «Primary General Education Teacher» profile)». The organization of students' practice at the faculty of pedagogy and methods of primary education is disclosed, the theoretical positions and features of the pilot project «Modernization of the practice of future teachers in conditions of continuing education in higher education» are described. The requirements for the selection of general education organizations as network partners have been singled out. The forms of interaction of all participants of the practice, positively evaluated by students, teachers-instructors, and methodologists of the university are revealed. The authors note that one of the important moments in the organization of the school-university partnership is the purposeful preparation and development of the professional skills of mentor teachers to accompany students in the practice. The main tasks of the School of Mentors are listed in the article.
I Am A Pediatric Dentist: Why is Major Depression Among Adolescents my Concern?
Authors: Waldman H. Barry , Perlman Steven P , Wong Allen
Published: May 2018

The question, “why a pediatric dentist should be concerned about major depression among teenagers” is considered in light of reports from the National Institute of Mental Health. The results of these studies indicate that there is a progressive increase in the proportion of adolescents with a history of major depressive episodes; ranging from 6.4% among 12 year olds to 15% and 16% for 15–17 year olds. There are great variations by gender, race and ethnicity in the proportion of teenagers experiencing major depressive episodes and receiving needed care. In addition, there is an increased proportion of teenagers with disabilities who experience major depressive episodes. This combined impact is a reality for youngsters with disabilities as they pass through the teenage years into adulthood. Listing of symptoms of depression are provided to facilitate dental treatment planning, as well as well as assisting parents/guardians in seeking the overall needed care for their youngsters.
Relief of Upper Airway Obstruction Using a Cervical Splint for Young Patients with Cerebral Palsy
Authors: Son Hyoju , Kim Soohyeon , Lee Jaeho , Kang Chungmin , Kim Seunghye
Published: May 2018

13-year old boy with spastic quadriplegia cerebral palsy visited dental clinic with chief complaints of mouth breathing and malocclusion. His mouth was constantly open at the resting position, with his mandible and tongue displaced downward. He breathed through his mouth, making a constant gurgling sound, a sign of upper airway obstruction. To enhance his mandible position, vertical chin cap was first considered, but it was not sufficient to reduce the gurgling sound or ease breathing. Then, cervical splint was considered, which effectively decreased the gurgling sound by repositioning his mandible to the anterior-superior position. Oxygen saturation was increased when the cervical splint was used. Cervical splint can effectively assist breathing in patients with cerebral palsy, but it should be carefully applied as long-term use can result in unexpected complications. Under instruction by a physician regarding proper usage, a cervical splint can be applied to assist breathing in patients with cerebral palsy.