bluuebunny/crossref_metadata_2025 huggingface dataset:
NGHIÊN CỨU ĐỘC TÍNH CẤP VÀ BÁN TRƯỜNG DIỄN CỦA CAO KHÔ HÀNH ĐEN
Authors: Phạm Văn Hiển , Nguyễn Hồng Sơn , Nguyễn Trọng Điệp , Lê Đức Hùng , Nguyễn Thị Thuỷ , Vũ Bình Dương
Published: November 2023

Mục tiêu: Đánh giá độc tính cấp và bán trường diễn của cao khô hành đen trên mô hình động vật thực nghiệm. Phương pháp nghiên cứu: Độc tính cấp của cao khô hành đen được đánh giá trên chuột nhắt trắng Swiss theo phương pháp Litchfield - Wilcoxon. Độc tính bán trường diễn của cao khô hành đen được đánh giá trên thỏ New Zealand White với liều lượng 375 mg/kg/ngày và 750 mg/kg/ngày trong 28 ngày và dựa vào các chỉ tiêu thường quy về xét nghiệm huyết học, sinh hoá máu và hình ảnh mô bệnh học. Kết quả: Chưa xác định được LD50 của cao khô hành đen tới mức liều cao nhất có thể cho chuột uống. Cao khô hành đen không gây độc với liều tối đa 3000 mg/kg ở chuột nhắt trắng. Cao khô hành đen cho thỏ uống ở các mức liều 375 mg/kg/ngày và 750 mg/kg/ngày trong 28 ngày không quan sát thấy sự thay đổi về tình trạng chung, không gây ra sự thay đổi về sự phát triển trọng lượng cơ thể thỏ; không quan sát thấy sự thay đổi có ý nghĩa về chỉ số hồng cầu, bạch cầu huyết sắc tố, nồng độ AST, ALT, creatinine và ure. Trên mô bệnh học, không thấy sự khác biệt giữa các lô thử và lô chứng về màu sắc, hình thái của gan, thận và lách. Kết luận: Cao khô hành đen không gây độc cấp tính với liều tối đa 3000 mg/kg trên chuột nhắt trắng và không gây độc bán trường diễn tới 28 ngày trên thỏ khi uống các mức liều 375 mg/kg/ngày và 750 mg/kg/ngày.
PHÂN TÍCH ĐẶC ĐIỂM PHÁC ĐỒ SỬ DỤNG THUỐC ĐIỀU TRỊ UNG THƯ TẠI BỆNH VIỆN TRUNG ƯƠNG QUÂN ĐỘI 108 NĂM 2022
Authors: Nguyễn Cẩm Vân , Nguyễn Trung Hà , Nguyễn Tuấn Quang , Nguyễn Khánh Huyền
Published: November 2023

Mục tiêu: Phân tích một số đặc điểm về phác đồ sử dụng thuốc điều trị ung thư tại Bệnh viện Trung ương Quân đội (BVTWQĐ) 108 năm 2022. Phương pháp nghiên cứu: Nghiên cứu hồi cứu, mô tả cắt ngang trên 65 bệnh nhân (BN) thông qua các hồ sơ bệnh án (HSBA) điều trị ung thư bằng thuốc tại BVTWQĐ 108 năm 2022 thỏa mãn tiêu chuẩn lựa chọn và loại trừ. Kết quả: Độ tuổi trung bình 52,37 ± 13,98 tuổi, tỷ lệ BN nam gấp gần 3 lần BN nữ. Ung thư phổi gặp nhiều nhất (18,46%). Hầu hết BN được chẩn đoán ban đầu ở giai đoạn nặng. Tăng huyết áp (THA) là bệnh mắc kèm xuất hiện nhiều nhất (23,33%). AC-T là phác đồ được sử dụng nhiều nhất (6,15%), chủ yếu là phác đồ kết hợp (75,96%) và không chuyển đổi phác đồ trong quá trình điều trị. Các biến cố bất lợi (ADE-Adverse Drug Event) phần lớn là độ 1 (71,04%), gặp nhiều nhất: Thiếu máu (50,58%). Thuốc hỗ trợ trong điều trị ung thư được sử dụng nhiều nhất: Thuốc chống dị ứng và dùng trong các trường hợp quá mẫn, hormone tuyến thượng thận, thuốc chống nôn. Kết luận: Phân tích được đặc điểm của 65 BN ung thư, đặc điểm về phác đồ sử dụng thuốc điều trị ung thư và các thuốc hỗ trợ trong điều trị ung thư tại bệnh viện năm 2022.
ĐÁNH GIÁ TÁC DỤNG AN THẦN, CẢI THIỆN GIẤC NGỦ CỦA BÀI THUỐC “AN THẦN ĐỊNH TRÍ QY” TRÊN MÔ HÌNH CHUỘT THỰC NGHIỆM
Authors: Nguyễn Thanh Hà Tuấn
Published: November 2023

Mục tiêu: Đánh giá tác dụng an thần, cải thiện giấc ngủ của bài thuốc “An thần định trí QY” (ATĐTQY) trên chuột nhắt trắng chủng Swiss. Phương pháp nghiên cứu: Sử dụng mô hình đo hoạt động ký để đánh giá tác dụng an thần và mô hình gây mất ngủ ở chuột bằng caffeine để đánh giá tác dụng cải thiện giấc ngủ pentobarbital. Chuột được cho uống ATĐTQY liều 36 g/kg/ngày và 108 g/kg/ngày (tính theo dược liệu khô). Kết quả: Trên mô hình đo hoạt động ký, tại các thời điểm sau 1 giờ và 3 giờ uống ATĐTQY ở cả 2 mức liều, số lần chuột di chuyển theo chiều ngang cũng như theo chiều dọc đều giảm rõ so với nhóm chứng (p < 0,05 và p < 0,01). Trên mô hình gây mất ngủ bằng caffeine, uống ATĐTQY ở cả 2 mức liều đều có độ trễ giấc ngủ giảm, thời gian ngủ tăng so với lô chứng bệnh (p < 0,01). Các tác dụng của ATĐTQY tương đương với Diazepam liều 2,4 mg/kg. Kết luận: Bài thuốc ATĐTQY liều 36 g/kg/ngày và 108 g/kg/ngày có tác dụng an thần, cải thiện giấc ngủ trên chuột thực nghiệm, tương đương với Diazepam liều 2,4 mg/kg.
SÀNG LỌC VÀ ĐÁNH GIÁ TÁC DỤNG HẠ ĐƯỜNG HUYẾT CỦA MỘT SỐ DƯỢC LIỆU Ở VIỆT NAM
Authors: Vũ Đức Lợi , Nguyễn Xuân Tùng , Lê Hồng Dương
Published: November 2023

Mục tiêu: Sàng lọc hoạt tính ức chế enzyme protein tyrosin phosphatase 1B (PTP1B) của sáu loại cây thuốc tại Việt Nam và đánh giá tác dụng hạ đường huyết in vivo của cao chiết dược liệu có khả năng ức chế enzyme tốt nhất. Phương pháp nghiên cứu: Dược liệu được chiết bằng ethanol 70%. Cao chiết được đánh giá tác dụng ức chế enzyme PTP1B in vitro. Tác dụng hạ đường huyết in vivo được tiến hành trên mô hình chuột đái tháo đường gây ra bởi streptozocin. Kết quả: Cao chiết phần trên mặt đất cây thài lài trắng thể hiện khả năng ức chế enzyme PTP1B mạnh nhất với giá trị IC50 là 8,34 ± 2,36 µg/mL khi so sánh với chất đối chứng dương acid ursolic (IC50 = 0,52 ± 0,04 µg/mL). Việc sử dụng cao chiết với liều 500 mg/kg và 1000 mg/kg làm giảm đáng kể nồng độ glucose máu và không ảnh hưởng đến trọng lượng, các chỉ số lipid của chuột thực nghiệm. Kết luận: Kết quả nghiên cứu cho thấy tiềm năng phát triển các sản phẩm hỗ trợ điều trị bệnh đái tháo đường từ cao chiết cây thài lài trắng.
PAIS NA ESCOLA E SUA IMPORTÂNCIA PARA A EFETIVAÇÃO DE UMA GESTÃO DEMOCRÁTICA: um estudo de caso no Colégio Estadual Analicia Cecília Barbosa da Silva /2022
Authors: IVANILDES ROCHA CLEONICE
Published: November 2023

Este trabalho aborda questões relacionadas com o envolvimento dos pais no processo de ensino/aprendizagem, investigando qual o impacto e importância desse envolvimento no desempenho escolar. Também, destaca o importante papel dos gestores escolares como base para a integração entre todos os envolvidos no processo de escolarização. Ressalta-se que um bom gestor escolar é aquele que une a comunidade escolar, que busca abrir as portas para uma educação de qualidade por meio do diálogo e que se compromete com o bem-estar de todos os membros dessa comunidade. O objetivo foi analisar as ações da gestão escolar no que diz respeito à efetividade da gestão democrática e das atividades cotidianas para garantir a participação dos pais nas atividades do Colégio Estadual Analícia Cecília Barbosa da Silva no Município de Amorinópolis-Goiás/2022. A metodologia adotada neste estudo insere-se no estudo de caso de abordagem qualitativa. A pesquisa qualitativa é ideal para abordar esse tema, pois permite uma compreensão subjetiva e específica desse fenômeno, permitindo considerar as complexidades das relações das crianças com seus cuidadores e demais participantes da educação. Foi utilizado como instrumento de pesquisa um questionário contendo seis questões sobre gestão escolar e envolvimento da família no ambiente escolar. Como resultado, das respostas obtidas, concluímos que o insucesso escolar está diretamente relacionado com o insucesso familiar e, quando os pais não cumprem os seus compromissos, encontramos casos de indisciplina escolar e dificuldades de aprendizagem. Por outro lado, vimos escolas empenhadas em criar um ambiente onde pais, alunos e gestores formem uma comunidade disposta a quebrar barreiras para alcançar uma educação de qualidade baseada no respeito e no diálogo.
Residual Effect of Biochar and Legumes on Soil Fertility, Yield and Yield Components of Wheat
Authors: Bangash Saqib Hussain , Ullah Farman , Azam Sajjad , Hussain Sharafat , Hussain Tasawar , Fatima Iza , Sherbano Bibi
Published: November 2023

Biochar and the use of legumes in cropping systems are considered sustainable approaches to boost crop yield and preserve soil fertility. In the current study, the effects of leftover biochar and previously planted legumes on wheat yield and soil N status were examined at various nitrogen (N) levels. The experiment included testing two levels of previously applied biochar (0 and 50 tons ha-1), three legumes under four levels of N (0, 60, 90, and 120 kg ha-1), cowpea (Vigna unguiculata) for fodder, Sesbenia (Sesbenia grandaflora) for green manuring, and mung bean (Vigna radiata) for grain. Results showed that biochar application enhanced wheat tiller m-2, spikes m-2, grains per spike, thousand grain weight, grain yield, biological yield, and soil total N status by 3%, 6.5%, 3.7%, 1.8%, 7.8%, 9.5%, and 11%, respectively. Moreover, applying nitrogen at a rate of 90 kg ha-1 increased the amount of wheat spike m-2 by 20%, grain spike-1 by 10%, grain yield by 70%, biological yield by 48%, harvest index by 27%, and the N content of the grain, straw, and soil by 13%, 14%, and 36% respectively. Meanwhile, 1000 grain weight resulted higher by 6.17%. Legumes that had been previously seeded outperformed fallow and increased spikes m-2, grain yield, biological yield, grain N content, and soil total N content by 8.2%, 11%, 6.78%, 25%, and 42%, respectively. It is determined that applying biochar to the summer gap left by legumes can increase soil fertility and wheat output.
RELAÇÃO ENTRE ATRIBUTOS FÍSICOS E AMBIÊNCIA, NA PERSPECTIVA DE ACOMPANHANTES, EM UM HOSPITAL INFANTIL
Authors: Hodecker Maísa , Menezes Marina , Moré Carmen Leontina Ojeda Ocampo , Felippe Maíra Longhinotti , Kuhnen Ariane
Published: November 2023

Trata-se de uma pesquisa etnográfica cujo objetivo foi identificar os atributos físicos de quartos de um hospital infantil que podem proporcionar desconforto e conforto ambientais, segundo a perspectiva dos acompanhantes. Participaram 50 acompanhantes, 47 do sexo feminino e 3 do sexo masculino. Utilizou-se, como ferramenta de coleta de dados, o diário de campo. Para analisar os dados, adotou-se o método de análise de conteúdo temática categorial, de Bardin. Os resultados indicaram quatro dimensões de análises: dimensão ambiental, bem-estar psicológico, afetiva e profissional. Entre os atributos físicos de valência negativa, o móvel de repouso foi mais frequente. Sobre os atributos físicos de valência positiva, a vista da janela e jardins internos no hospital foram destacados por favorecer o bem-estar. A televisão e o uso de aparelhos celulares foram percebidos como distrações positivas. Verificou-se que a estrutura hospitalar deveria conter espaços de diálogos entre acompanhantes, assim como áreas verdes com acesso livre.
O A POSTERIORI DA PESQUISA EM PSICANÁLISE:
Authors: Kegler Paula , Macedo Mônica Medeiros Kother
Published: November 2023

O artigo explorou a existência de dois tempos na produção de uma investigação: a narrativa do participante e a hospitalidade na escuta do pesquisador. Por meio de um delineamento qualitativo via pesquisa narrativa, que estimulou os relatos dos participantes sobre suas experiências na situação de entrevista (e a partir dela), foram identificados dois tempos que viabilizaram, a posteriori, a produção de novos sentidos para aquele que se narra e para aquele que o acolhe, via escuta sensível. Assim, o enlace entre esses dois tempos proporcionou uma nova leitura do sujeito sobre si e permitiu ao pesquisador compor um singular saber sobre a produção de conhecimento em pesquisa. Constatou-se, como fator potencializador desse processo, a sensibilidade ao outro, uma vez que, ao favorecer condições efetivas à hospitalidade da escuta, o pesquisador lançou luz sobre novos elementos que se constroem a partir do encontro proporcionado nessa modalidade de investigação.
Art, Music, and Humour in Theodor Mintrop’s Album for Minna
Authors: Rose Margaret A.
Published: November 2023

This is the first book in English alone on the 19th Century German artist and friend of Robert and Clara Schumann, Theodor Mintrop (1814-1870). Although he began studying at an academy of art only at the age of 30, Mintrop was inspired at a young age by the art of Raphael (1483-1520) and was one of the favourite students of the Nazarene artist and Director of the Düsseldorf Academy of Art, Wilhelm von Schadow (1788-1862), who depicts him in the novella Der moderne Vasari of 1854 as the ideal artist “Theodor”. Because both the real and the fictional Theodor were discovered by another of Schadow’s students while he was working on his family’s farm, he was also dubbed the “rural Raphael”. While many of his paintings and sketches reflect the style and beauty of Raphael’s works, Theodor Mintrop also drew numerous sketches, in which the works of Raphael and other artists are interwoven with contemporary scenes, poetry, and musical references in humorous ways. It is above all in his sketches for his friends and relatives that Mintrop’s comic artistic in-jokes are to be found, and this is certainly the case with this rediscovered album of 72 pages of sketches for the amateur pianist Minna Bozi of 1855-1857. Theodor Mintrop’s album of sketches for Minna is reproduced here in full and in colour with thanks to the Landesarchiv Nordrhein-Westfalen Abteilung Ostwestfalen-Lippe, Detmold and with notes on both the art and music referred to in them. Explanations of its sketches (based on those published in the German-language editions of the album of 2003 and 2020) show Mintrop to be both a rural and a comic Raphael, for whom the imitation and reinvention of another work could be a homage as well as a humorous modernisation.
La admiración poética en Ernestina de Champourcin : "Mi admirado, querido y constante amigo Juan Ramón"
Authors: Lozano Marín Laura
Published: November 2023

Este artículo se propone analizar la admiración poética que profesó Ernestina de Champourcin a Juan Ramón Jiménez. Para ello se analizan diferentes aspectos de poemarios escritos en el primer tercio de siglo XX como son En silencio (1926), Ahora (1928) y La voz en el viento (1931), así como de las dos poéticas que la autora redactó y de la autobiografía dedicada al poeta moguereño, La Ardilla y la Rosa. (Juan Ramón en mi memoria) (1981).
The I, the Eye, the Voice
Authors: Agamben G.
Published: November 2023

This publication marks the first Russian translation of an essay by Giorgio Agamben, originally published in 1980 as a preface to the Italian edition of Paul Valéry’s cycle of works on Monsieur Teste. Agamben’s essay delves into the philosophical genealogy of Valéry’s character, Monsieur Teste, presenting him as an extension and radicalization of the Cartesian gesture of self-justification through the experience of cogito. Through Valéry’s texts, Agamben uncovers a constitutive link between Descartes’ legacy and the ultimate experience of language as revealed in Valéry’s poetry. This exploration identifies the aporia of Cartesian subjectivity, characterized by an inherent split between the experinces of seeing (eye) and hearing (voice). The significance of this essay lies in its connection to Agamben’s broader project on the human voice, which he contemplated throughout the 1980s. While some ideas from the never-completed book The Human Voice surfaced in other works, such as “Childhood and History: The Destruction of Experience” (1978) and “Language and Death: The Place f Negativity” (1982), “The I, the Eye, the Voice” holds a special place in this series. It not only offers an interpretation of Valéry’s experiences within a philosophical context but also lays the groundwork for several key ideas about voice in Agamben’s recent writings. Particularly, these concepts are elaborated upon in the chapter on voice from What is Philosophy? (2016). Therefore, this commentary on Valéry’s writings not only stands as an independent work but also serves as a pivotal element of Agamben’s overarching philosophical project.
Stress and Coping Strategies of Madrasah’s Teachers on Applying Distance Learning During COVID-19 Pandemic in Indonesia
Authors: Muawanah Siti , Muzayanah Umi , G. R. Pandin Moses , D. S. Alam Mochamad , P. N. Trisnaningtyas Januari
Published: November 2023

The COVID-19 pandemic has changed many aspects of life, including face-to-face learning processes in madrasah to distance learning. These changes have caused psychological problems or stress among teachers. The study aims to describe the mental health issue during COVID-19 and how to overcome it. The study applied quantitative and qualitative approaches, with 1,520 teachers, consisting of 615 teachers from Islamic Schools (madrasah) in Bali and 905 in NTT. Findings indicate that the stress level experienced by madrasah teachers in the two provinces was in a low category at a score of 1.54, though both regions were at very different levels in terms of internet affordability, the highest cause of teacher stress was the concern for students’ ability to absorb the learning material; and 92.68% of teachers selected problem-focused coping mechanisms, particularly efforts to improve their skills in conducting distance learning. The findings from the study provide important input for teachers’s coping strategies for mental health issues of distance learning.
Suivis acoustiques de biodiversité : perspectives et défis en milieu continental terrestre
Authors: LE BORGNE Hélène , BOUGET Christophe
Published: November 2023

Les animaux produisent des sons pendant leurs activités ou pour assurer diverses fonctions biologiques comme la défense de territoires, l’attraction de partenaires, la dissuasion des prédateurs. En enregistrant ces données acoustiques, les scientifiques obtiennent des informations essentielles sur la présence des espèces. Les nouvelles technologies d’identification des espèces sont plus abordables, efficaces et polyvalentes que les méthodes classiques et peuvent ainsi répondre au besoin urgent de documenter la biodiversité dans le contexte actuel de crise. Les enregistreurs acoustiques automatisés sont de plus en plus utilisés dans les suivis de biodiversité pour faire face aux limites des méthodes plus traditionnelles et à l’émergence de considérations déontologiques préconisant le développement de pièges non destructifs (i.e. non létaux). Nous présentons ici les outils d’acquisition des données en milieu continental terrestre, les méthodes de gestion et d’analyse des données pour la classification automatique des espèces et l’étude des paysages sonores, et les avantages et les limites de l’utilisation de ces outils dans un objectif de suivi de la biodiversité en milieu terrestre.
Strategi Inovatif untuk Meningkatkan Budaya Literasi dengan Model Pembelajaran Kooperatif Tipe TGT dan Media Ular Tangga pada Materi Perubahan Masyarakat Masa Islam di SMP Muhammadiyah 2 Taman Sidoarjo
Authors: Maryati Nofi , Saputra Bachtiar Adi
Published: November 2023

This article explores the use of innovative strategies in improving literacy culture among class 8B students at SMP Muhammadiyah 2 Taman Sidoarjo. The main focus of this research is to apply the TGT (Teams-Games-Tournaments) type cooperative learning model combined with the snakes and ladders game media in learning material about changes in Islamic society. Involving aspects of geography, economics, social and culture, this approach aims to stimulate interest in reading, increase understanding and build students' literacy skills. The research method applied in this research carries a combinative approach between the TGT (Teams-Games-Tournaments) type cooperative learning model and the snakes and ladders game media. The results of observations carried out showed a significant increase in students' active participation during the learning process. Students are more actively involved in group discussions, questions, and given assignments. They are not only recipients of information, but also main actors in their own learning. This increase in participation indicates that TGT's cooperative approach and the snakes and ladders game media are able to create a learning environment that stimulates more intensive student involvement. Evaluation of the impact of this innovative strategy in more detail is measured through assessment tests. Positive results on the test show that the TGT cooperative approach and the snakes and ladders game media have a real impact on students' academic achievement. The conclusion we can draw is that this innovative strategy proves that the use of the TGT cooperative learning model with the snakes and ladders game media can be an effective step in improving literacy culture among students.
Retrospective Assessment of an Adalimumab Model–Informed Precision Dosing Support Tool for Use in Pediatric Inflammatory Bowel Disease
Authors: Avalos Yesenia , Gothard M. David , Moses Jonathan , Finkler Michael
Published: November 2023

OBJECTIVES

Therapeutic drug monitoring in pediatric inflammatory bowel disease (IBD) has been used to achieve and maintain remission. Few guidelines exist to aid clinicians in the adjustment of anti–tumor necrosis factor therapies. The objective was to assess the agreement between real-world postinduction and posteriori analysis of retrospective data, using 2 novel pharmacokinetic (PK) models for adalimumab.

METHODS

A retrospective chart review was conducted in pediatric IBD patients treated with adalimumab. A Bayesian clinical decision support tool (InsightRX) was used. Postinduction serum concentration measurements of adalimumab were performed by drug-tolerant, homogenous shift mobility assay. Predicted serum adalimumab concentrations from both models were compared to the actual serum concentrations through a Bland-Altman analysis. Paired sample t test was used for equivalence.

RESULTS

A total of 47 patients were included. Forty-one patients (87%) had Crohn disease, and 30 (64%) were male. Most were induced with 160 mg of adalimumab and maintained on 40 mg biweekly. No significant difference resulted between the de Klaver average prediction and mean population concentration (p = 0.294). Significant difference was observed between Ternant and mean population serum adalimumab concentration (p < 0.001). The Bland-Altman plot for the de Klaver method showed no proportional bias. Additionally, 49% of patients required a dose adjustment during maintenance therapy.

CONCLUSIONS

The de Klaver model was able to provide less bias than the Ternant model and may aid in predicting serum adalimumab concentrations. Approximately half of the patients required dose adjustment during maintenance therapy to obtain a therapeutic drug concentration or achieve clinical remission.
The Use of Dexmedetomidine in Preterm Infants: A Single Academic Center Experience
Authors: Guillen-Hernandez Juan , Kyllonen Kay C. , Tumin Dmitry , Rodriguez Ricardo J.
Published: November 2023

OBJECTIVE

Preterm newborns (PTNBs) often require sedation and analgesia. Dexmedetomidine (DEX) is used to provide sedation in extremely PTNBs, even though information on such use is limited. The objective of this research is to describe the use of DEX in these patients in a single academic center.

METHODS

This is a retrospective study of PTNBs receiving DEX from January 1, 2010, through December 31, 2018, at the Cleveland Clinic Children’s Hospital, a tertiary academic center operating 2 Level III and 1 Level IV neonatal intensive care units (NICUs). Inclusion criteria were gestational age (GA) <36 weeks and receipt of DEX for >2 days. Adequacy of clinical response was based on achieving Neonatal Pain, Agitation and Sedation Scale (N-PASS) scores <3. Hypotension, bradycardia, and respiratory depression were recorded as the incidence as adverse events.

RESULTS

A total of 105 patients were included. The birth weight median was 870 g (IQR, 615–1507); the GA median was 26 weeks (IQR, 24–31). The duration of DEX infusion averaged 7 days. The DEX dose averaged 0.4 mcg/kg (IQR, 0.3–0.45). Bradycardia was observed in 35 patients (57%) weighting <1 kg and in 7 patients (18%) >1 kg (p < 0.01). There was no difference in the incidence of other adverse events between these groups. However, infants <1 kg required more pharmacologic interventions to maintain N-PASS score <3.

CONCLUSIONS

DEX was well tolerated overall and provided adequate sedation to PTNBs in this cohort. From this study, we recommend a starting dose of 0.2 to 0.4 mcg/kg/hr and titrating up hourly until adequate sedation is achieved.
Kırgızca Deyimlerde Geçen Güzellik ve Güzel Görünüm İle İlgili Kültürel Algılar
Authors: GÜMÜŞ Muhittin , ESHKENOV Doolotbek
Published: November 2023

İnsan; tıp alanında fizyolojik bir yapı, sosyolojide toplumun bir üyesi, psikolojide farklı bir benlik sistemi ve yaratıcılığın unsuru, ekonomide sistem içinde bir birim, teolojide Tanrı’nın yarattığı en mükemmel canlı, antropolojide kültürün işlediği bir varlık sayılmaktadır. Dilbilimde insanın kendisi değil onun dili ve dille ilişkisi bütün boyutlarıyla ele alınır. İnsanoğlu yaratıldığından beri değişik arayışlar içindedir. Sürekli olarak daha iyiyi, daha güzeli, daha estetik olanı ve mükemmeli aramaya devam ederken yaşadığı kültürel çevrede kişisel hazlarını, içgüdüsel davranışlarını daha seçici ve etkili kullanma arzusunu da devam ettirdiği görülür. Yaratılmışların üstünü olarak tanımlanan insan; güzellik ve güzelliğin unsurlarından, ölçütlerinden güzellik duygusundan geri kalamayacağını bu kavramları bilim ve felsefe alanına kadar ileri götürmesinden anlamak mümkündür. Dünyada bütün kültürlerde olduğu gibi Türk uygarlığının içinde köklü bir geçmişe sahip olan Kırgız kültüründe de dile yansıyan güzel görünüm ve güzellik kavramını ifade eden sözler vardır. O sözler leksikolojik unsurlar içinde kısa ve öz olarak deyimler aracılığıyla yansıtılmıştır. Bu çalışmamızda Kırgızca deyimlerde geçen güzellik ve güzel görünüm ile ilgili kültürel algılara yer verilmiştir.Dünyada bütün kültürlerde olduğu gibi Türk uygarlığının içinde köklü bir geçmişe sahip olan Kırgız kültüründe de dile yansıyan güzel görünüm ve güzellik kavramını ifade eden sözler vardır. O sözler leksikolojik unsurlar içinde kısa ve öz olarak deyimler aracılığıyla yansıtılmıştır. Bu çalışmamızda Kırgızca deyimlerde geçen güzellik ve güzel görünüm ile ilgili kültürel algılara yer verilmiştir.
LOCALIZATION OF CORPORATE SOCIAL RESPONSIBILITY STRATEGY OF KOREAN MULTINATIONAL CORPORATIONS IN SOUTHEAST ASIA: A COMPARATIVE STUDY OF THAILAND AND VIETNAM
Authors:   , Bang Ji
Published: November 2023

This study aims to explore how the local environment influences Corporate Social Responsibility (CSR) of Korean Multinational Corporations (Korean MNCs) operating in Southeast Asia. In-depth interviews were conducted with executives of five Korean MNCs operating in Thailand and Vietnam. All interviewed companies had the character of weak CSR structure and unsystematic CSR approach in common. Within these organizational limitations, different domestic environment between the two countries affected their CSR development. The interviewed companies in Vietnam performed strategic CSR, which responded to the social issues and the requirement of host country, under the greater pressure on CSR from the Vietnamese society. There were various external forces in CSR decision-making channel, and they recognized the local government as the object of solidarity and cooperation in CSR. In Thailand, the interviewed companies accepted CSR as a part of the culture, which is on voluntary basis and donation-centered, or did not receive any influence from the domestic environment. As a result, their CSR performance have been mostly ‘responsive CSR’, which means one-off event or short-term philanthropy. Consequently, the result revealed that the different domestic factors, such as the government’s policy, social pressure and culture regarding CSR, largely affect CSR strategy and activities of Korean MNCs in Thailand and Vietnam.
INTERNATIONAL MARRIAGE: THAI WOMEN AND SINGAPOREAN MEN IN SINGAPOREAN PATRIARCHAL SOCIETY
Authors:   , Trivivit Kavee
Published: November 2023

The study of international marriages between Thai women and Singaporean men in Singapore aims to investigate the phenomenon of such marriages. The paper examines gender relations, influence of stereotypes, cultural and structural forces that guide Singaporean society, individual choices and expectations in a marriage in the present and the future. The study relies on qualitative research methods in particular in-depth interview with twenty couples in total. The main theories include, Takashi Inoue’s theory of international marriage, Abraham Maslow’s hierarchy of needs, and Anthony Giddens’ structuration theory. Based on the findings, there is a conflict in choices of mate selections and expectations in a marriage of such couples. These conflicting ideas have caused a point of contention and created an unhappy marriage for couples involved in international marriage. The lingering of such negative sentiments can prove to be catastrophic for these couples. However, these couples are simply not victims of their circumstance. Instead, they are active agents who continuously endeavour to make progress in their lives and social status as a couple.
Effect of exercise-induced fatigue in hot environment compared with thermoneutral environment on postural stability after single-hop jump
Authors:   , Keerasomboon Taspol
Published: November 2023

It’s well-known that muscle fatigue is a key factor to deteriorate postural stability. In addition to, hyperthermia is enhancing the effect of muscle fatigue when exercise performed in hot environment compared with thermoneutral environment. Objective: To study the effect of exercise-induced fatigue on the dynamic postural stability in hot environment compared with thermoneutral environment and estimate the relative contributions of central and peripheral factors development of muscle fatigue. Method: twenty three-active male performed exercise-induced fatigue by 20-minute cycling exercise both in hot environment (31-33 ͦ C 60% relative humidity) and thermoneutral environment (23-25 ͦ C 50% relative humidity). Postural stability was measured by Dynamic postural stability index (DPSI) Integrated electromyography/compound muscle action potential (IEMG/CMAP) method was used to estimate the relative contributions of central and peripheral factors development of muscle fatigue. Results: DPSI after exercise-induced fatigue in hot environment (0.99 ± 0.15) was significantly (P < 0.05) higher than in thermoneutral environment (0.48 ± 0.10 ) For the IEMG/CMAP values, the (iEMG) signal after exercise-induced fatigue significantly decrease compared with before exercise, while the CMAP amplitude was unchanged. Conclusion: Effect of exercise-induced fatigue in hot environment had worse postural stability than in thermoneutral environment and the contribution factors relate to changes in central nervous system (CNS) which involve to central fatigue.
EFFECTS OF ENGLISH SPEAKING INSTRUCTION USING STORIES ON SPEAKING ABILITY AND PARTICIPATION OF THAI EFL SECOND GRADE STUDENTS IN INTERNATIONAL SCHOOLS IN THAILAND
Authors:   , Sanglir Stephen
Published: November 2023

This research project aimed to study 1) the effects of English Speaking Instruction Using Stories on the Speaking Ability of Second Grade Thai EFL Learners in an International School 2) the students' participation in the English Speaking Instruction Using Stories. The samples for this study were Thai EFL learner participants from the second grade level in an international school in Thailand. The instruments used in this research were a speaking pre-test and post-test, and student talk diaries and classroom observations form. The data was analysed using descriptive statistics: mean scores, S.D., and dependent t-test, and content analysis. The findings of the study indicated that 1) the speaking post-test mean scores were higher than that of the pre-test at a significant level, 2) the students showed positive participation in the English Speaking Instruction Using Stories.
EFFECTS OF COMBINATION OF DIRECT AND INDIRECT WRITTEN CORRECTIVE FEEDBACK ON GRAMMATICAL ACCURACY IN NEW PIECES OF WRITING OF UPPER SECONDARY SCHOOL STUDENTS IN THAILAND
Authors:   , Somwong Warunya
Published: November 2023

The purposes of this study were to investigate the transfer effects of the combination of written corrective feedback including direct and indirect corrective feedback on students’ grammatical accuracy in new pieces of writing and to compare the difference between providing the combination of written corrective feedback in different orders. The participants in this study were forty eleventh grade students in Sainampeung School. The participants were divided into two groups and provided with the combination of written corrective feedback which are direct and indirect corrective feedback in the different orders in each experimental phase. The study was conducted in the second semester of the academic year 2016 in Reading and Writing course. The comparison table of errors, six writing tasks and students’ interview were used as the research instruments. The data were analyzed by using means, standard deviation, and t-test. The findings revealed that the combination of written corrective feedback had transfer effects on students’ grammatical accuracy in their subsequent writing at .01 significance level. When analyzed the effects of providing the combination of written corrective feedback in different orders, the finding showed no significant difference in the grammatical accuracy improvement between providing with the written corrective feedback in different order. Lastly, students were found to have positive attitudes towards direct written corrective feedback more than indirect written corrective feedback.
Innovation of new product and service development model harnessing cultural heritage
Authors:   , Tanyavutti Anawat
Published: November 2023

The purpose of this dissertation is to propose Front-end of Innovation (FEI) process for the concept development of cultural products by harnessing cultural heritage as source of inspiration. The process is divided into 2 phases, idea generation and idea screening. The ideation technique combines Morphological Analysis (MA) with Cultural Design Model theory. The morphological matrix is built based on in-depth interview with 10 designers with rich experience in cultural product design from key cultural industries of Thailand. The matrix is further developed into web-based ideation tool for conducting case study research with 10 designers. The results from case studies, the concepts generated, were evaluated in terms of quantity of ideas and quality of ideas for validation of the idea generation method. Regarding idea screening phase, Means-end chain theory and the Schwartz’s universal human values were applied to discover attributes-consequences-values linkages of consumers purchasing cultural products, and 8 types of chain were identified. Data from 2 phases of the research were incorporated to develop the idea generation support system assisting designers and entrepreneurs seeking to develop concepts of products and services harnessing Thai cultural heritage as central value. The final idea generation support system was evaluated in terms of usability and thereby the diffusion of innovation employing Technology Acceptance Model. The study yields multiple implications. Regarding academic contribution, this study contributes to the domain of Front-end of Innovation process of culture-driven products, which have not been widely discussed despite their great potential. The proposed techniques and the idea generation support system would be used as foundation for future research regarding new product development of cultural products. As for managerial implication, the idea generation support system would assist designers and entrepreneurs to develop concepts of culture-driven products, essentially those in countries with rich cultural asset and in industries which rational benefits or technological advancement are deemphasized.
Literature in gold : Ramakien as depicted on Thai lacquerware cabinets from the early Rattankosin period
Authors:   , B. Goss,
Published: November 2023

The purpose of this research was to examine the use of the Thai rendition of the Rama story, know as Ramakien, as depicted on gold on black lacquerware cabinets from the early Rattanakosin period by combining various elements of Thai Studies, including Thai literature, Thai art, Thai history and Thai Buddhism. The objective of the study was to see how such depictions have been used and then address the question of why the ostensibly secular Rama narrative was used on cabinets designed to hold the sacred Buddhist scripture. This study examined the 376 lacquerware cabinets held by the National Library of Thailand assigned to the Rattanakosin period and found that of those that have some form of narrative depiction, approximately half can be associated with the Rama story, more than for any other group of narrative, including traditional Buddhist narratives, such as the Life of the Buddha and the jātaka tales. It was found that the Rama related depictions tend to focus on scenes of fighting and combat, traditionally scenes that have been popular for performance in khon masked dance drama and nang yai shadow puppetry. However, interestingly, the scene that is depicted the most is that of the ‘Death of Intharachit’, a scene not typically part of the performance repertoire. It can be concluded from this study that the Rama story, as depicted on the lacquerware cabinets, was used in a symbolic manner to create the presence of Phra Ram and convey the message of Phra Ram acting, either in association or conjunction with the king, as the protector and guardian of Buddhism. Along with this symbolic meaning, one could also read a didactic message through the depictions of the Rama story, that being to convey a lesson of the triumph of good/truth over evil/ignorance.
PREVENTIVE EFFECTS OF CLITORIA TERNATEA EXTRACT ON METHYLGLYOXAL-INDUCED PROTEIN GLYCATION, OXIDATIVE DNA DAMAGE AND ADIPOGENESIS
Authors:   , Chayaratanasin Poramin
Published: November 2023

This study was aimed to determine the inhibitory effects of Clitoria ternatea extract (CTE) on glycation of BSA, oxidative DNA damage, and adipogenesis mediated by methylglyoxal (MG). The results showed that polyphenols in CTE identified by LC-MS/MS were ternatins, delphinidin derivatives, quercetin-3-rutinoside, apigenin-7-O-neohesperidoside , Kaemferol-3-O-rutinoside, (+)-catechin-7-O-b-glucoside, and syringetin-3-O-glucoside. CTE (250-1,000 µg/mL) significantly inhibited fructose- and MG-induced formation of fluorescent, non-fluorescent AGEs, fructosamine, amyloid cross β structure, protein carbonyl content and preventing free thiol depletion in BSA system. CTE (250-1,000 µg/mL) suppressed oxidative DNA strand breakage through inhibition of superoxide anion and hydroxyl radical production in 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) and MG/lysine system. The mechanisms of anti-glycation of CTE are a direct carbonyl trapping ability and free radical scavenging activity. In early phase, CTE (500-1,000 µg/mL) inhibited MG-mediated adipogenesis through suppression of cell proliferation related to Akt and ERK1/2 signaling pathway in 3T3-L1 preadipocytes. In late stage of adipogenesis, CTE inhibited MG-induced expression of adipogenic transcription factors including PPARγ and C/EBPα and subsequently down-regulation of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), causing the reduction of TG accumulation in mature adipocytes. When the cells were incubated without MG, CTE (500-1,000 µg/mL) treatment markedly decreased cell differentiation through Akt and ERK1/2 signaling pathway in the early stage of adipogenesis together with suppression of mRNA expression of adipogenic genes (PPARγ and C/EBPα) in late stage of adipogenesis. Furthermore, CTE could enhance lipolysis in mature adipocytes. The inhibition of MG-induced adipogenesis by CTE was due to its effects on the regulation of Akt and ERK1/2 signaling pathway and adipogenic transcription factors and the direct MG trapping ability. This study indicates that CTE can be a potential candidate for the prevention of protein glycation and adipogenesis.
Prevalence, perception and risk factors of canine obesity in Thailand
Authors:   , Thaotumpitak Varangkana
Published: November 2023

The proportion of obese dogs is increasing worldwide. It has become a topic of interest as it can impair quality of dog’s life and reduce longevity. The objectives of this study were to determine prevalence and risk factors of canine obesity in Thailand, misperception of owner on body shape of dogs and relationship between canine obesity and laboratory parameters. A cross-sectional study was performed with dogs aged over 1 year regardless of breed, sex and health status from 6 regions of Thailand (n=2,401). Results showed that prevalence of canine obesity was 42.94%. Risk factors by multivariable analyses were age 3-8 years old (OR=1.98), neutering (OR=1.63), snacking once daily (OR=1.47), and having obese dogs in the same household (OR=2.37). A comparison of body shape evaluation by owners and veterinarian showed discrepancy of these two assessments (p<0.0001) with 18.5% of dog owners underestimated their dogs’ body shape. Risk factors of underestimation were age >8 years old (OR= 1.90) and neutering (OR= 1.26). Blood collection was done for hematology and blood chemistry profile evaluation in two groups of dogs; clinically healthy non-obese dogs (n=50) and obese dogs (n=50). Total cholesterol and triglyceride were higher in obese dogs compared with non-obese dogs (p<0.05).

In conclusion, this is the first report about prevalence of canine obesity in Thailand. The high prevalence of obesity was found in this study (42.94%). In addition, misperception of owner on evaluation of body conformation may lead to lack of concern and being an obstacle for weight control regimen. Some laboratory parameters may be used as a diagnostic tool to promote awareness of the owners.  Canine obesity should be considered as a part of basic health program and client education is needed in order to have successful control of canine obesity.
EFFECTS OF DNA-MLV PRIME BOOST IMMUNIZATION ON MODULATION OF PRRSV-SPECIFIC IMMUNE RESPONSES IN HP-PRRSV CHALLENGED PIGS
Authors:   , Sirisereewan Chaitawat
Published: November 2023

Porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized as the important swine pathogen that threaten swine industry globally. The quasispesies character of PRRSV causes genetic variation, leading to the emergence of the new variant type 2 PRRSV, known as highly pathogenic PRRSV (HP-PRRSV). HP-PRRSV first emerged in China in 2006 and then spread to circulate in the Southeast Asia region. Currently, commercially available modified live PRRS vaccines (MLV) are not able to provide complete protection against the HP-PRRSV, and have been reported to induce negative immunomodulatory effects in vaccinated pigs. Interestingly, a novel DNA vaccine was developed and successfully used to improve PRRSV-specific immune responses following MLV vaccination. To investigate the efficacy of a heterologous DNA-MLV prime-boost immunization against the HP-PRRSV infection, an experimental vaccinated-challenged study was conducted. Two-week-old, PRRSV-seronegative, crossbred pigs (5-8 pigs/group) were allocated into 5 groups. At day-14 (D-14), the treatment group (DNA-MLV) was immunized with a DNA vaccine encoding PRRSV-truncated nucleocapsid protein (pORF7t), followed by a commercial modified live, type 2 PRRS vaccine (MLV) at D0. The other groups included the group that received PBS at D-14 followed by MLV at D0 (MLV), pORF7t at D-14 (DNA), PBS at D0 (PBS) and the negative control group. At D42, all groups, except the negative control group, were challenged with HP-PRRSV (strain 10PL1). The results demonstrated that pigs that received MLV, regardless of the DNA priming, exhibited less clinical signs and faster viral clearance. Following HP-PRRSV challenge, the DNA-MLV group exhibited improved PRRSV-specific immunity, as observed by increased neutralizing antibody titers and PRRSV-specific IFN-g production, and reduced IL-10 and PRRSV-specific Treg productions. However, neither the prime-boost immunization nor the MLV was able to induce complete clinical protection against HP-PRRSV infection. In conclusion, improved immunological responses, but not complete clinical protection, were achieved by DNA-MLV prime-boost immunization. This study highlights the potential use of heterologous prime-boost vaccination regimen, where DNA can be incorporated with other vaccine candidates, for improving anti-PRRSV immunity that may eventually lead induction of complete PRRSV protection.
Tick diversity and pathogen infection in Khao Chi-On non hunting area and banglamung wildlife breeding center, Chonburi province, Thailand
Authors:   , Wattanamethanont Juntra
Published: November 2023

Ixodid ticks are important vectors in the transmission cycle of various tick-borne diseases in both humans and animals. Wildlife are considered important reservoirs of these diseases. This study aims to examine tick diversity, and tick-borne protozoal and bacterial infection in questing ticks in wildlife habitats by using PCR and DNA sequencing techniques. In 2015, questing ixodid ticks were collected from Khao Chi-On Non Hunting Area and Banglamung Wildlife Breeding Center, Chonburi province. All 12,184 ticks were identified using morphological characteristics and representative ticks were confirmed species by PCR that targeted tick mitochondrial 16S rRNA gene. Three tick species were identified including Haemaphysalis lagrangei (92.82%), H. wellingtoni (0.13%), and Rhipicephalus (Boophilus) microplus (7.05%). Totally, 419 tick samples (Individual adult and nymph, and pooled larvae) were examined by using PCR which amplified a fragment of 18S rRNA gene of Babesia and Theileria, and 16S rRNA gene of bacteria in family Anaplasmataceae. Out of 419 analyzed tick samples, four pathogens and one bacterial symbiont were detected, with the highest infection rate of Anaplasma spp. at 55.61% (233/419) with three genotype groups including Anaplasma closely related to A. bovis, A. platys, and unidentified Anaplasma. While Theileria spp. had lower infection rate at 4.30% (18/419) with three genotypes consisted of Theileria closely related to T. cervi, T. capreoli, and unidentified Theileria, and only one sequence (1/419; 0.24%) of Babesia spp., Ehrlichia spp. and Wolbachia spp. were detected. These findings provided the information of tick diversity in wildlife habitats, and the association with detected tick-borne protozoa and bacteria. It suggested the evidences that these tick species are possible vectors to transmit tick-borne diseases in forest of Thailand. Furthermore, these data would be useful for designing treatment, prevention, and control strategies of tick-borne diseases.