bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Drug-Drug Interactions by Means of a Graph Look Network Novel Algorithm
Authors: Baskaran Dr. T. S. , Arunkumar M.
Published: August 2023

Abstract: With the growing need for public health and drug development, combination therapy has become widely used in clinical settings. However, the risk of unexpected adverse effects and unknown toxicity caused by drug-drug interactions (DDIs) is a severe public health issue for polypharmacy safety. Traditional investigational methods for detecting DDIs are expensive and time- consuming. Therefore, many computational methods have been developed in recent years to predict DDIs with the growing availability of data and advancements in artificial intelligence. In silico methods have proven to be effective in predicting DDIs, but detecting potential interactions, especially for newly exposed drugs without an existing DDI network, remains a challenge. In this study, we proposea predicting method of DDIs named HAG-DDI based on graph look networks. We consider the differences in mechanisms between DDIs and add learning of semantic-level attention, which can focus on superior representations of DDIs. By treating interactions as nodes and the presence of the same drug as edges, and constructing small subnetworks during training, we effectively mitigate potential bias issues arising from limited data availability. Our experimental results show that our method achieves an F1-score of 0.952, proving that our model is a viable alternative for DDIs prediction. The codes are available at: https://github.com/xtnenu/DDIFramework.
Buckling Analysis of Laminated Composite Plate Using FE Method
Authors: Raje Kapil , Vimal Jyoti , Chaturvedi Vedansh
Published: August 2023

Abstract: This study investigates the use of finite element analysis to composite plate structures. The major purpose of this research is to use FEA techniques to evaluate the buckling behavior of composite plates. FEA simulation and CAD modeling are both possible with the help of ANSYS APDL. It has been determined that carbon composite is a material and that the individual plates may take on either a hexahedral or a quadrilateral geometry. The buckling load of the plate is determined by applying the structural loads on it. The FEA is performed for all permutations, which include changing the h/b ratio from 0.08 to 0.16 and then from 0.16 to 0.24. The buckling load is determined by the eigenvalues and is different for each h/b ratio. According to FEA predictions, increasing the h/b ratio increases the buckling load. The findings of this study suggest that finite element analysis (FEA) may be utilized to enhance the design of composite structures subjected to a wide range of loading scenarios.
PSICOLOGIA HOSPITALAR E CUIDADOS PALIATIVOS: ATUAÇÃO COM PACIENTES ONCOLÓGICOS
Authors: Santos Clara Cecília Ribeiro dos , Figueiredo Letícia Almeida Teixeira da Silva de , Reis José de Arimatéia Rodrigues
Published: August 2023

Oncology is the science dedicated to studying cancer, its etiology and possible treatments. In this regard, psycho-oncology emerges, which acts in prevention, in receiving the diagnosis, in the treatment and in the follow-up of people who are beyond therapeutic possibilities. Therefore, palliative care, in psycho-oncology, is a comprehensive and holistic approach, which aims to improve the quality of life of cancer patients and their families, in intra- and extra-hospital settings. This study aims to identify and analyze the performance of hospital psychologists with cancer patients in palliative care, based on the method of integrative bibliographical review of the scientific literature. Searches were carried out for scientific articles in the databases of Google Scholar, Scielo, Virtual Health Library (BVS), Virtual Health Library Psychology Brazil (BVS PSI) and Pepsic, using the following combinations of descriptors: "psychologist" & "care “hospital psychology” & “cancer patients” and “hospital psychology” & “palliative care”. Ten indexed articles, published between 2018 and 2023, were selected. The results show that the role of the hospital psychologist is extremely important in the palliative care clinic, highlighting the relevance of this role within the multidisciplinary team, in which the psychologist plays an essential role, by offer assistance and therapeutic listening to the demands generated by cancer. It was considered that the psychologist's performance has a great impact on the mental health of cancer patients and palliative care, reducing anxieties related to the complex disease that affects the body and emotions.
A EXPERIÊNCIA DE MATERNAGEM EM MÃES DE BEBÊS PRÉ-TERMO INTERNADOS EM UNIDADE NEONATAL
Authors: Nunes Isadora Elaine Sales , Diniz Dalciney Maximo
Published: August 2023

A baby is considered preterm when it is born before 37 completed weeks of gestation, and it is necessary to admit it to a Neonatal Unit (NU) after birth. In addition to breaking with the fantasy of the imaginary baby, prematurity involves an anticipation of the process of recognizing oneself as a mother. This context of crisis provides a space of difficult elaboration around the experience of having a baby who was born prematurely and who is admitted to a hospital, bringing repercussions for the mother-infant relationship and for his psychic constitution. This work aims to investigate the experience of mothers of preterm babies admitted to the UN, based on Psychoanalysis. This is an integrative review study based on publications found in the Scielo, PePsic, LILACS and Redalyc databases in the last 10 years. The descriptors Prematurity, Psychoanalysis, Maternity and Neonatal ICU were used. 14 articles were selected for review of 67 identified general publications. It was found that the experience of mothers of preterm babies admitted to the NU is permeated by feelings of guilt, fear, frustration and ambivalence. The premature baby birth it is considered a risk factor for bonding, but it does not prevent mothers from finding strategies to exercise their role and bond. It is important to support the multidisciplinary team in the mothers' coping process and the psychologist's work in providing a listening space, allowing parents to talk about the experience and elaborate a place of subject for this baby.
Stability analysis of fat and polyphenol content of five cocoa clones grown in different environment in Indonesia.
Authors: Al-Afandi Muhammad , Anita Sari Indah , Wahyu Susilo Agung , Widura Ritonga Arya , Setyawan Bayu , Malik Abdul
Published: August 2023

Fat and polyphenols are functional compounds in cocoa beans that determine product quality and are highly influenced by environmental factors. Informationregarding the stability of the character of the polyphenol and fat content of the cocoa plant is still limited, therefore it needs further study. This study aimed todetermine the stability of fat and polyphenol content in several cocoa clones at three different growing locations. The study used a nested design with a randomized block design with field design consisting of five cocoa clones, three different growing locations and each combnation treatment was repeated three times. The cocoa clones used were ICCRI 09, MCC 02, Sulawesi 1, KW 516, and KW 562, planted in three different growing locations namely, Kaliwining Experimental Station, Jember, East Java; Sekampung Udik, East Lampung, Lampung; and Harapan Jaya, Pesawaran, Lampung. The combined analysis of variance indicated that there was a genetic interaction with the environment for the character of fat and polyphenol content. Based on the stability analysis, it is known that all cocoa clones fall into the stable category according to the concept of static stability. Furthermore, based on addtive main effect and multiplicative interaction (AMMI) analysis, the clones that can be recommended for Jember, East Lampung and Pesawaran locations for the character of fat content are clone KW 516, while for the characters of high and stable polyphenol levels at the three locations are clones MCC 02, KW 516, and KW 562. In addition, the most recommended clone based on fat content at Jember was the MCC 02 clone, KW 562 at East Lampung, and KW 516 clone at Pesawaran. The existence of the phenomenon of genetic interaction and the growing environment for the characters of fat and polyphenols in cocoa plants provides important information, especially in considering the development of cocoa for specific purposes, namely parameters of fat and polyphenols.
Refined finite-size analysis of binary-modulation continuous-variable quantum key distribution
Authors: Matsuura Takaya , Yamano Shinichiro , Kuramochi Yui , Sasaki Toshihiko , Koashi Masato
Published: August 2023

Recent studies showed the finite-size security of binary-modulation CV-QKD protocols against general attacks. However, they gave poor key-rate scaling against transmission distance. Here, we extend the security proof based on complementarity, which is used in the discrete-variable QKD, to the previously developed binary-modulation CV-QKD protocols with the reverse reconciliation under the finite-size regime and obtain large improvements in the key rates. Notably, the key rate in the asymptotic limit scales linearly against the attenuation rate, which is known to be optimal scaling but is not achieved in previous finite-size analyses. This refined security approach may offer full-fledged security proofs for other discrete-modulation CV-QKD protocols.
Response Surface Methodology-Based High-Throughput BioLector Fermentation Screening of Rosetta™-2 for Enhanced Production of Insulin Variant: Towards Improved Production Efficiency
Authors: Ayan Esra , Aytekin Ali Özhan , Katı Ahmet , DeMirci Hasan
Published: August 2023

Background: To obtain high yields of recombinant insulin and advancing
therapeutic avenues for diabetes patients, the development of innovative
designer insulin analogs have critical importance. The modified insulin
analog presents a cost-effective remedy by being produced as inclusion
bodies (IBs) within Escherichia coli BL21 (DE3) Rosetta-2 strain. This
approach to production not only offers reduced production time but also
yields high recovery rates. The prime aim of this investigation was to
optimize the composition of the cultivation media, thereby accomplishing
higher cell density fermentation of the proinsulin. Result: Various
factors, including carbon and nitrogen sources, salts, metal ions, and
pH, were systematically investigated through experimental screening
using the BioLector multiwell bright plate. Additionally, computational
analysis employing the Plackett-Burman Design within the Design Expert
software was utilized to assess their effectiveness in terms of insulin
concentration as a surrogate measure of insulin yield. Among the tested
variables, glucose, glycerol, MgSO4, and lower Luria-Bertani mix
concentration have a significant influence on insulin production, as
determined by the screening experiment. Subsequently, the Central
Composite Design approach was operated to further evaluate and optimize
the precise levels of these influential variables. This systematic
methodology achieved an optimized cultivation media formulation,
resulting in a remarkable enhancement of insulin production, with levels
reaching up to 13 mg/ml when applied in BioLector fermentation.
Conclusion: The formulated cultivation media exhibited suitability for
promoting high cell density fermentation of the modified insulin,
thereby facilitating the attainment of optimal yields for the proinsulin
expression.
Anastrozole as a therapeutic option for gynecomastia in a person receiving antiretroviral treatment: case report
Authors: Senkoro Elizabeth , Varadarajan Maithili , Candela Caterina , Antoniad Christina , Boffito Marta
Published: August 2023

A middle-aged Caucasian man presented with a six-month history of
bilateral enlargement of the breasts associated with pain. His hormonal
profile was normal and no other underlying cause was identified, we
diagnosed him with idiopathic gynecomastia. He is living with HIV,
clinically stable (viral load <20copies/mL) and on injectable
antiretrovirals cabotegravir/rilpivirine. Tamoxifen is an anti-estrogen
recommended for gynecomastia and has been described in persons living
with HIV. In this case, tamoxifen could potentially induce the activity
of cytochrome P450 3A4 (CYP3A4), reducing rilpivirine concentrations,
which consequently may cause virological failure. According to the
National Health Service (NHS) guidelines in the UK, an aromatase
inhibitor can be used in place of tamoxifen. To date, there have been no
reported cases of using anastrozole as a treatment for gynecomastia in
people living with HIV, or of its co-administration with
antiretrovirals.
Sweat gland necrosis and bullous skin changes in acute drug intoxication.
Authors: Brehmer-Andersson E , Pedersen NB.
Published: August 2023

No abstract available
False-positive serological test for syphilis in pregnancy.
Authors: Salo OP , Aho K , Nieminen E , Hormila P
Published: August 2023

No abstract available
Studies on the origin of the mucin in mucinosis follicularis.
Authors: Langner A , Jablonska S , Darzynkiewicz Z.
Published: August 2023

No abstract available
Ultrastructure of Cryptococcus neoformans
Authors: Hino H. , Takizawa K. , Asboe-Hansen G.
Published: August 2023

The ultrastructure of C. neoformans was studied in two cases of cutaneous cryptococcosis. Extracellular and intracellular fungi were observed. Their capsules and clear zones were thick and distinct, but their cytoplasmic organelles were not obvious. In macrophages, a few stages of fungal degeneration could be observed. It could not be ascertained whether the changes were caused by anti-fungal drugs or by an influence by host macrophages. The ultrastructure of the yeast cells in vitro appeared to be that of degenerated cells because of a long culture period.
The validity of the pathergy test (non-specific skin hyperreactivity) in Behçet´s disease: a double-blind study by independent observers
Authors: Altaç M. , Tüzün Y. , Yurdakul S. , Binyildiz P. , Yazici H.
Published: August 2023

No abstract available.
Food iron absorption in patients with dermatitis herpetiformis
Authors: Braide I. , Kastrup W. , Magnusson B. , Mobacken H. , Rossander L.
Published: August 2023

No abstract available.
In vitro studies on blastogenic lymphokine activity in nickel allergy
Authors: MacLeod TM. , Hutchinson F. , Raffle EJ.
Published: August 2023

No abstract available.
Suppression of erythema nodosum by indomethacin
Authors: Ubogy Z. , Persellin RH.
Published: August 2023

Erythema nodosum (EN) can be a debilitating illness. Many treatment modalities have been suggested but none is universally effective. We describe three patients with severe EN secondary to streptococcal pharyngitis who were unresponsive to large doses of aspirin. Following the administration of indomethacin in doses of 100 to 150 mg per day, all three showed a dramatic response, with prompt resolution both of systemic symptoms and of local signs of inflammation. The lesions of EN involve the lower cutis, with inflammation of septae and fat lobules. It is likely, therefore, that the local liberation of fatty acids leads to increased prostaglandin synthesis which, in turn, is responsible for the intense inflammation. The impressive suppression of EN by indomethacin could be related to the inhibition of prostaglandin synthetase in the subcutaneous fatty tissues.
Transepidermal water loss and sweat gland response in lamellar ichthyosis before and during treatment with etretinate: report of three cases
Authors: Kiistala R. , Lauharanta J. , Kanerva L.
Published: August 2023

No abstract available.
Acantholysis induced by proteolytic enzymes. I. Porcine pancreatic elastase
Authors: Hino H. , Kobayasi T. , Asboe-Hansen G.
Published: August 2023

In an attempt to induce acantholysis in cultivated normal human epidermis, porcine pancreatic elastase was used. After 30 minutes, the intercellular contact layers of desmosomes appeared discontinuous. Following the disappearance of the intercellular filamentous structures, desmosomes ruptured into two, and in 3 hours, typical acantholysis was observed. After 15 minutes, prior to the desmosomal changes, dermo-epidermal separation started at the subepidermal space. After 2 hours of elastase influence, anchoring filaments and the basal lamina were degraded. Five hours from the start of culture, the anchoring fibrils remained undigested by elastase. The mechanism of elastase influence on epidermis is assumed to depend rather on its proteolytic activity than on its elastolytic activity.
5-OH-dopa, product of and substrate for tyrosinase
Authors: Agrup G. , Rorsman H. , Rosengren E.
Published: August 2023

The formation of 5-OH-dopa on incubation of tyrosine or dopa with mushroom tyrosinase was studied. Dopa oxidase activity was defined by measuring the formation of 5-S- and 2-S-cysteinyldopa from dopa in the presence of excess amounts of cysteine. This procedure quantitating the immediate nucleophilic reaction products of dopaquinone constitutes a new method for assessing tyrosinase activity. The rate of 5-OH-dopa formation from dopa was similar to that of the formation of dopa from tyrosine. The rate of dopaquinone formation was one order of magnitude higher. When tyrosine was oxidized in the presence of ascorbic acid, 5-OH-dopa formation represented 14% of the original amount of tyrosine. At low concentration of dopa, formation of 5-OH-dopa was proportional to the dopa concentration. At high concentrations the relative quantity of 5-OH-dopa formed decreased. Tyrosine in high concentrations inhibited the formation of 5-OH-dopa from dopa. 5-OH-dopa proved to be a substrate for tyrosinase. The rate of oxidation of 5-OH-dopa was similar to that of dopa. The oxidation products of 5-OH-dopa were transformed into relatively stable fluorophores.
The chloroacetate esterase reaction for mast cells in dermatopathology: a comparison with metachromatic staining methods
Authors: Wong E. , Morgan EW. , MacDonald DM.
Published: August 2023

This paper compares standard metachromatic methods with Leder´s chloroacetate esterase reaction on mast cells in paraffin wax-embedded tissue of urticaria pigmentosa and a variety of inflammatory and benign neoplastic cutaneous conditions. Our conclusions are that Leder´s method allows easier identification of mast cells and can be a useful adjunct to conventional metachromatic methods. The technique could be conveniently adopted in routine dermatopathology for mast cell identification.
A retrospective study of cataract formation in 96 patients treated with PUVA
Authors: Hammershøy O. , Jessen F.
Published: August 2023

Studies in guinea pigs have shown formation of cataract when they are treated with 8-methoxypsoralen (8-MOP) and UVA irradiation. 96 patients treated with PUVA between 1975 and 1980 were examined to observe if cataract formation had occurred more frequently in these patients. No patient developed cataract during the PUVA treatment period and these findings were found to correspond to those in a "standard population".
Lichen aureus: a case report
Authors: Weismann K. , Kobayasi T.
Published: August 2023

Lichen aureus (LA) is a distinctive, rare disease occurring predominantly in males, characterized by solitary rust- or copper-coloured patches of lichenoid micropapules, often present on fingers and calves. A case of LA in a 41-year-old male is presented. Biopsy revealed the characteristic pattern of LA, including a dense dermal infiltrate of lymphocytes and histiocytes containing haemosiderin. No epidermal changes were present.
Ophthalmological study of patients undergoing long-term PUVA therapy
Authors: Rönnerfält L. , Lydahl E. , Wennersten G. , Jahnberg P. , Thyresson-Hök M.
Published: August 2023

In the present study 46 patients with severe psoriasis maintained on long-term PUVA therapy have been followed up to 6 1/2 years after the initiation of treatment. Repeated ophthalmological examinations were performed in order to detect any early sign of lens changes. No ocular side effects attributed to the photochemotherapy were revealed during this period. Continued use of appropriate eye shielding is recommended and also routines to remind patients to actually wear their protective glasses.
Multiple comedones confined to xanthelasma
Authors: Tsuji T. , Furukawa M. , Soejima R. , Hamada T.
Published: August 2023

No abstract available.
Demonstration of 5,6-dihydroxyindole-2-carboxylic acid, a melanin precursor, in normal urine
Authors: Hansson C.
Published: August 2023

No abstract available.
Methaemoglobin-catalysed formation of dopa and 6-OH-dopa from tyrosine
Authors: Agrup G. , Hansson C. , Rorsman H. , Rosengren E. , Tegner E.
Published: August 2023

An extract of bovine retina and choroid with tyrosine hydroxylating and dopa-oxidizing capacity also showed marked formation of 6-OH-dopa on incubation with tyrosine and ascorbic acid. The extract contained appreciable amounts of methaemoglobin as determined spectrophotometrically, and boiled extracts also showed catalytic activity. The effect of methaemoglobin on the oxidation of tyrosine and dopa was therefore investigated. Methaemoglobin catalysed the formation of dopa and 6-OH-dopa in the presence of tyrosine and ascorbic acid. Hydrogen peroxide plays an important role in this reaction: the rates of formation of both dopa and 6-OH-dopa were increased by addition of hydrogen peroxide but diminished by addition of catalase. Methaemoglobin also catalysed the formation of cysteinyldopa from dopa and cysteine.
Bacteria and fungi in severe foot infection
Authors: Noble WC. , Clayton YM. , Davies H. , Blatchford NR.
Published: August 2023

In a study of severe foot infection in 21 miners, an attempt was made to match nine clinical parameters with both bacteriological and mycological findings. Erythema was significantly more pronounced in the presence of dermatophytes but less pronounced in the presence of Gram-negative bacilli. No other clinical parameter differed in relation to the presence of particular microorganisms.
Methotrexate in psoriatic arthritis: a retrospective study
Authors: Kragballe K. , Zachariae E. , Zachariae H.
Published: August 2023

The response of psoriatic arthritis to methotrexate was evaluated retrospectively in 59 consecutive patients. Initially almost all received 15 mg weekly. When clinical improvement occurred, the dose was gradually reduced. In 7 patients methotrexate had to be discontinued within a year due to adverse reactions. The remaining 52 patients were treated from 1 to 11 years, median 3 years. Among these a modest improvement was seen in 21, while in 22 the signs of inflammatory joint disease almost disappeared. The favourable response was related to the short duration of arthritis, but unrelated to the severity of the disease.
Multicentric reticulohistiocytosis: a case report
Authors: Hansen E. , Nilsen R. , Milde EJ.
Published: August 2023

With the present case report we call attention to the clinical entity of multicentric reticulohistiocytosis (MR). Referring to earlier case reports on this rare condition we present the history, clinical and histopathological findings. We stress the importance of revealing possible underlying internal diseases, including malignancies, and also the importance of histological examination of synovium when synovectomies are carried out in patients with arthritis of unknown cause, as arthritis commonly precedes the mucocutaneous lesions by years.
5-S-cysteinyldopa and pigment response to UVA light
Authors: Tegner E. , Rorsman H. , Rosengren E.
Published: August 2023

5-S-Cysteinyldopa concentrations in serum were studied in healthy individuals exposed to daily high-intensity UVA radiation. A marked increase in 5-S-cysteinyldopa was found after 3 days, and in some individuals concentrations were still higher after 7 to 10 days. The immediate pigment darkening (IPD) and delayed tanning (DT) were weak or absent at pressure sites, i.e. in skin with a low concentration of oxygen.
Psoriasis and vitiligo
Authors: Powell FC. , Dicken CH.
Published: August 2023

Twenty-nine patients with vitiligo and psoriasis observed over a 5-year period were reviewed. The incidence of concurrence of both diseases was not increased, and the onset and course of the psoriasis and vitiligo were separate. Psoriatic lesions occurred on vitiliginous areas and normal skin with equal frequency. These patients had a larger number of associated diseases than normally seen in psoriatics.
HLA studies in chronic dermatophytosis caused by Trichophyton rubrum
Authors: Svejgaard E. , Jakobsen B. , Svejgaard A.
Published: August 2023

The HLA-ABC antigens were investigated in 34 and DR antigens in 28 patients with chronic dermatophytosis caused by Trichophyton rubrum. The distribution of the antigens did not differ from that of the controls. Abnormal immune response may be of importance in the susceptibility to chronic dermatophytosis, but HLA-controlled immune mechanisms seem unlikely.
Contact urticaria to commercial fish in atopic persons
Authors: Beck HI. , Nissen BK.
Published: August 2023

The frequency of contact urticaria provoked by certain fish prepared in the Danish fish industry was examined in 14 persons with atopia. In 71.4% of the test persons we found positive confirmation in a 20-minute scratch patch test to one or more fish species. All occluded patch tests were negative, while 33.9% of the scratch patch tests were positive. It was impossible to make a correlation between positive scratch patch tests and atopic allergen/total IgE. The investigation emphasizes that atopics have a higher frequency of contact urticaria to fish than have non-atopics.
Factitious lymphoedema, Secretan´s syndrome
Authors: Jørgensen J. , Gammeltoft M. , Schmidt H.
Published: August 2023

No abstract available.
Induction of leukocyte adherence at the basement membrane zone with subsequent activation of their metabolic pathway by pemphigoid antibodies and complement
Authors: Iwatsuki K. , Tagami H. , Yamada M.
Published: August 2023

We observed in our in vitro studies that human leukocytes were attached by their complement receptors to the basement membrane zone (BMZ) of the skin specimens pretreated with pemphigoid antibodies and complement. The resultant histologic feature was very similar to that of an early stage of the inflammatory reactions observable in the lesions of bullous pemphigoid. Eosinophils were also attracted to the BMZ in proportion to their number in cell suspensions, but the adhesion of eosinophils occurred neither selectively nor excessively. The nitroblue tetrazolium (NBT) test, which was carried out after the leukocyte attachment test, demonstrated that only those leukocytes bound specifically to the BMZ incorporated NBT dye complexes vigorously to form formazan crystals in their cytoplasms. The present studies showed that complement-fixing anti-BMZ antibodies induce enhancement of leukocyte activities as well as immune adherence to the BMZ, indicating that the enhanced leukocyte function plays a role in the separation between epidermis and dermis in bullous pemphigoid.
Pruritic urticarial papules and plaques of pregnancy (PUPPP)
Authors: Noguera J. , Moreno A. , Moragas JM.
Published: August 2023

Pruritic urticarial papules and plaques of preg­nancy (PUPPP) has been defined as an intensely pru­ritic cutaneous eruption occuring in the third trimester of pregnancy. 11 resolves spontaneously or at parturition. We present our experience with 15 cases of this new entity.
Familial streblodactyly
Authors: Donofrio P. , Ayala F.
Published: August 2023

A family is described in which female members of two generations were affected from birth from a flexion deformity of the fingers. The pedigree analysis suggests the possibility of a sex-limited autosomal dominant pattern of inheritance. This rare condition, which has been reported only once in the literature, is known by the term streblodactyly (streblos = Gr. twisted, crooked).
Mutilating palmo-plantar keratoderma
Authors: Gamborg Nielsen P.
Published: August 2023

A 36-year-old male, with no history of hereditary palmo-plantar keratoderma, showed at the age of 2-3 years a typical keratoderma of the Unna Thost variety on palms and soles. At the age of 16 years he developed mutilating symptoms localized to the fingers. Radiologic examination showed abnormally pointed end phalanges.
Concomitant immunohistochemical characteristics of pemphigoid and dermatitis herpetiformis in a patient with atypical bullous dermatosis
Authors: De Jong MC. , Van der Meer JB. , De Nijs JA. , Van der Putte SC.
Published: August 2023

We report a patient who developed a vesiculobullous eruption which clinically and histologically showed features of pemphigoid and dermatitis herpetiformis, responded to prednisone but doubtfully to dapsone, and demonstrated ´classical´ immunopathologic characteristics of phemphigoid and dermatitis herpetiformis. Peribullous and unaffected skin featured deposition of IgG and C3c in a homogeneous-linear pattern at the epidermal basement membrane, while the unaffected skin demonstrated concomitantly granular IgA deposits in the dermal papillae. Circulating IgG class anti-basement membrane antibody was found in a titre of 1:80 when using guinea-pig oesophagus, and of 1:320 when using human oral mucosa as antigenic substrate. Our findings add another piece to the puzzle that continues to stimulate discussion among dermatologists as how to classify patients with overlapping features of pemphigoid and dermatitis herpetiformis. (Received February 18, 1983.)
Treatment of cutaneous T-cell lymphomas with TP-5. Evaluation of the clinical effect in 8 patients
Authors: Przybilla B. , Burg G. , Schmoeckel C. , Braun-Falco O.
Published: August 2023

Eight patients with cutaneous T-cell lymphomas (6 patients with mycosis fungoides, 1 patient with S√©zary´s syndrome, 1 patient with low-grade malignant lymphoma, unclassified) were treated with TP-5, a synthetic pentapeptide having the same biologic activity as the thymic hormone thymopoietin. TP-5 was administered three times weekly at a dosage of 50 mg subcutaneously in 6 patients, 50 mg intravenously in 1 patient, and 100 mg subcutaneously in 1 patient. Clinical evaluation at the end of the trial disclosed improvement in 4 patients (2 patients with mycosis fungoides, 1 patient with S√©zary´s syndrome, 1 patient with low-grade malignant lymphoma, unclassified), deterioration in 3 patients with mycosis fungoides and no change in 1 patient with mycosis fungoides. As TP-5 evidently exerts some effect on cutaneous T-cell lymphomas, further investigations of its therapeutic potential in this group of diseases seem worthwhile.
Fibrin microclot formation in patients with acne
Authors: Juhlin L. , Michaëlsson G.
Published: August 2023

After the addition of E. coli polysaccharide to blood from patients with deep inflammatory acne, microclots formed in all patients, whereas this was rarely seen in mild acne and never in controls. Furthermore, spontaneous microclot formation without addition of endotoxin was seen in 5 of the 10 patients with the most severe acne.
Photosensitivity induced by piroxicam
Authors: Fjellner B.
Published: August 2023

A woman with rheumatoid arthritis developed an erythematous-bullous eruption on light-irradiated areas following sun exposure. Treatment with piroxicam, had been initiated 14 days earlier. The clinical picture, the relationship in time to the drug administration and a positive photopatch test gave reason to suspect piroxicam-induced photosensibility. Piroxicam (Felden) is a new non-steroid anti-inflammatory agent which was registered in Sweden in 1981. Various adverse skin reactions have been described. Thus, there has been one case of Lyell´s syndrome with a fatal outcome (7), two case reports of erythema multiforme-like reactions (1, 3) and two reports of patients with erythemato-papulous and also bullous eruptions restricted to light-exposed skin areas (3).
Chondrodermatitis nodularis chronica helicis treated with curettage and electrocauterization: follow-up of a 15-year material
Authors: Kromann N. , Höyer H. , Reymann F.
Published: August 2023

During the 15-year period from 1965 to 1979 a total of 142 cases of chondrodermatitis nodularis chronica helicis were diagnosed. 32% were women, a higher proportion than in earlier materials. The treatment was principally curettage followed by electrocauterization. 78 patients were re-examined after an average lag of 7.1 years. The relapse rate was 31%. This simple surgical technique seems equal to the more elaborate procedures in respect of recurrence rate and more satisfactory from a cosmetic point of view.
Ultrastructure of oral mucous membrane lesions in psoriasis
Authors: Kanerva L , Hietanen J.
Published: August 2023

The ultrahistopathology of six patients with psoriatic oral mucosal membrane lesions is described. Four of the patients had tongue lesions (geographic or fissured tongue) and two had lesions of the buccal mucosa. The same features were found in both types of lesions. The most prominent feature was the large number of neutrophils. Neutrophil pustules caused flattening of the keratinocytes, resulting in a sponge-like network of epithelial cells. Other features were the dilated fenestrated capillaries surrounded by neutrophils and oedema of the upper lamina propria, basal lamina gaps, basal spongiosis and keratinocyte activation. Psoriasis lesions of the oral mucosa belong to the group of diseases characterized by epithelial non-bacterial pustules.
On the role of the C1-esterase inhibitor in cold urticaria
Authors: Nilsson T , Bäck O.
Published: August 2023

Plasma samples from 20 patients with acquired cold urticaria were studied. The C1-esterase inhibitor activity was found to be low, but the total C1-esterase inhibitor concentration was normal. Prekallikrein, plasmin-alpha 2-antiplasmin complex, and kallikrein-like activity were also found to be within normal limits. Cold-promoted activation of coagulation factor VII occurred in 45% of the patient plasmas and resulted in a considerable drop in C1-esterase inhibitor activity.
Drug eruptions: causative agents and clinical types. A series of in-patients during a 10-year period
Authors: Kauppinen K , Stubb S.
Published: August 2023

A series of 446 inpatients with drug eruption was studied to determine the causative agent and the clinical type. In over a half of the cases a provocation test confirmed the drug responsible for the reaction. Sulphonamides/trimethoprim and ampicillin/penicillin followed by phenazones were the most frequent agents causing eruptions. Sulphonamides were also the most common drugs inducing Lyell´s and Stevens-Johnson syndromes. Phenazones and barbiturates were the main causes of fixed eruptions. The frequency of inpatients having drug eruption was decreased in the 1971-80 series compared with the earlier one from 1961-70. Also the frequency of Lyell´s and Stevens-Johnson syndromes was lower in the latter decade than in the earlier one.
Mondor´s phlebitis of the penis: a study with factor VIII related antigen
Authors: Tanii T , Hamada T , Asai Y , Yorifuji T.
Published: August 2023

Four patients with so-called non-venereal sclerosing lymphangitis of the penis are reported. It was suggested that the affected vessels were veins by positively stained factor VIII related antigen with the unlabeled peroxidase-antiperoxidase method. If cord-like linear subcutaneous swelling observed in the coronary sulcus or dorsal region of the penile shaft originate from the vein, it seems correct to call this disease as Mondor´s phlebitis of the penis.
Trichoepithelioma, cystic acne and 13-cis-retinoic acid
Authors: Van Voorst Vader PC , Van Oostveen F , Hasper MF.
Published: August 2023

Treatment with 13-cis-retinoic acid during 12 weeks of a patient with multiple trichoepitheliomas and acne cystica et comedonica did not affect the number of trichoepitheliomas. The cystic lesions, most of them trichoepitheliomas with only a few non-inflammatory cystic acne lesions, were not affected by this treatment.
Phagocytosis by mast cells in urticaria pigmentosa
Authors: Krüger PG , Nyfors A.
Published: August 2023

Mast cells with endocytic and autophagic vacuoles were observed in a biopsy from a lesion of urticaria pigmentosa. In several areas of the specimen the mast cells revealed the typical morphology of mast cells which have released low molecular weight mediators, but this phenomenon did not seem to be correlated morphologically to the phagocytic activity of the mast cells. Some mast cells contained giant granules with a normal as well as an abnormal substructure.
Dapsone and human polymorphonuclear leucocyte chemotaxis in dermatitis herpetiformis
Authors: Millar BW , Macdonald KJ , Macleod TM , Raffle EJ.
Published: August 2023

Polymorphonuclear leucocyte chemotaxis was investigated in 6 patients with active dermatitis herpetiformis in the untreated state and when under control with Dapsone. Control studies were undertaken in 7 healthy volunteers. No significant difference in chemotaxis was demonstrated between the active, treated and control groups. Furthermore, when Dapsone in physiological concentrations was added separately in all three groups there was no additional effect on chemotaxis. These results clearly show that polymorphonuclear leucocytes from active untreated dermatitis herpetiformis have normal chemotactic activity compared with those from the same patients in the treated state and controls. Additional Dapsone did not alter these findings.
Scabietic leucocytoclastic vasculitis with focal glomerulonephritis
Authors: Menné T , Christophersen J , Gram N , Bjerrehus T.
Published: August 2023

No abstract available.
Panniculitis in Pseudomonas aeruginosa septicemia
Authors: Llistosella E , Ravella A , Moreno A , De Moragas JM.
Published: August 2023

A 71-year-old man developed multiple subcutaneous nodules during Pseudomonas aeruginosa septicemia. The acute and simultaneous flare of inflammatory nodules in a septic patient appears to be rather specific in Pseudomonas infections. Histological vascular lesions are prominent in the subcutaneous nodules.
Serum total and unbound testosterone and sex hormone binding globulin (SHBG) in female acne patients treated with two different oral contraceptives
Authors: Palatsi R , Hirvensalo E , Liukko P , Malmiharju T , Mattila L , Riihiluoma P , Ylöstalo P.
Published: August 2023

Serum total an unbound testosterone (T) and sex hormone binding globulin (SHBG) levels were studied in fifty-four female acne patients before treatment and during the treatment by two different oral contraceptives, the other containing 0.150 mg desogestrel plus 0.03 mg EE and the other 0.150 mg levonorgestrel plus 0.03 mg EE. Pretreatment values were abnormal in 57% of the patients. A borderline significant correlation between the severity of acne and SHBG was found. Ater six months´ treatment a 250% increase in SHBG was seen in desogestrel/EE group and no significant change in SHBG in levonorgestrel/EE group. However, at the same time serum free testosterone fell 60% in both treatment groups. SHBG cannot be the only regulator of serum free testosterone. Acne improved significantly in both treatment groups. It is likely that the improvement was in connection with the free testosterone decrease and the improvement was better in the desogestrel/EE group where also SHBG elevation was seen.
Measurement of transepidermal water loss using an evaporimeter to follow the restitution of the barrier layer of human epidermis after stripping the stratum corneum
Authors: Frödin T , Skogh M.
Published: August 2023

The rate of evaporation after stripping a test area with adhesive tape was followed in 10 women over a period of 15 days. The much increased transepidermal water loss after stripping diminished rapidly on the first 3 days. It then decreased more slowly, approaching but not fully reaching the normal rate by the end of test period. This can be taken to reflect the repair process of the damaged barrier layer. The instrument used makes possible instantaneous reading of the rate of evaporation, and is highly suited for assessing the function of the barrier layer.
Eosinophilic granuloma associated with a 16q22 chromosomal defect of cutaneous T lymphocytes
Authors: Bisballe S , Thestrup-Pedersen K , Bjerring P , Jensen JJ , Ottosen PD , Kaltoft K.
Published: August 2023

A 61-year-old woman presented with circumscribed eczematous eruptions with maceration, erosions and patchy infiltration in the perineum and inframammary regions. A diagnosis of eosinophilic granuloma (cutaneous histiocytosis X) was established. T lymphocytes from a skin biopsy were grown in vitro for three weeks after which chromosomal studies revealed a break or gap at chromosome 16q22 in 15% of the lymphocytes. The addition of alpha-interferon increased the percentage of affected cells to 28%. T lymphocytes from the patient´s blood did not show the defect. The biological significance of the chromosomal defect is uncertain. It has been described before in healthy persons, malignant lymphoma, cold urticaria and IgA deficiency, and mental retardation. It has not been seen in patients with eosinophilic granuloma.
Ultrasonic B-scanning of the human skin. An introduction of a new ultrasonic skin-scanner
Authors: Tikjøb G , Kassis V , Søndergaard J.
Published: August 2023

A high frequency, high resolution dynamic ultrasonic skin-scanner is described. The skin-scanner is shown to give a cross-sectional image of the skin and provides an accurate, simple and non-invasive method for measuring full-thickness human skin. In addition to the skin thickness it is demonstrated that the underlying subcutaneous fat and muscles can also be non-invasively explored with the possibility of identifying a variety of skin and underlying tissue lesions.
Vascular changes in morphea
Authors: Kobayasi T , Serup J.
Published: August 2023

Vascular changes in morphea were studied in skin biopsies from 14 patients. Small vessels with pericytes present the changes in three different patterns. The first was the endothelial cells in a stimulated condition and thickened vascular wall with infiltrating macrophages and mast cells. The second was characterized by thick basal lamina of pericytes and the third by activated pericytes with infiltrating lymphocytes and plasma cells. Otherwise, all patterns showed altered endothelial cells and infiltrating macrophages and mast cells similar to the first pattern. The first pattern was mostly found in uninvolved skin. The second and the third were found in the inflammatory and sclerotic areas. It seems, therefore, that activated pericytes are the most essential changes in vessels of morphea. Probably, muscular vessels are simply involved in the fibrotic process.
Increased platelet aggregation in psoriasis
Authors: Hayashi S , Shimizu I , Miyauchi H , Watanabe S.
Published: August 2023

Platelet aggregation was measured in fasting platelet-rich plasma in 25 psoriatics, 6 of whom were diabetic, 50 normal controls, and 24 diabetics. The aggregating agents employed to induce platelet aggregation included ADP, epinephrine and collagen. Platelet aggregation was significantly increased in psoriatics compared with normal controls. An additive effect was observed when diabetes was associated with psoriasis, with platelet aggregation being further increased by ADP. Platelet aggregability was re-evaluated in 7 psoriatics after they presented with clearing of the rash. The increased platelet aggregation with ADP and epinephrine was significantly reduced when the skin lesions had cleared.
Langerhans´ cells in seborrheic keratosis. A clinical and ultrastructural study
Authors: Nyfors A , Krüger PG.
Published: August 2023

Skin biopsies from 10 patients with seborrheic keratoses were examined by electron microscopy for the presence of Langerhans´ cells. Comparing seborrheic keratoses with normal skin of the same patient and with normal skin from controls, neither an increased number of Langerhans´ cells nor an increased number of specific granules, Birbeck granules, nor abnormal Langerhans´ cells, was found. Melanosomes in a Langerhans´ cell were observed in 2 seborrheic keratoses, suggesting phagocytic activity of the Langerhans´ cell.
Quantitation of contact allergy in guinea pigs by measuring changes in skin blood flow and skin fold thickness
Authors: Andersen KE , Staberg B.
Published: August 2023

Skin blood flow determined by laser Doppler flowmetry (LDF) and skin fold thickness (SFT) have been used to quantitate allergic contact dermatitis in the guinea pig maximization test (GPMT) using chlorocresol as the allergen. The closed patch test procedure itself influenced both LDF and SFT measurements when determined in 12 sham-treated guinea pigs. The LDF was maximal at 24 hours and the SFT at 48 hours. Before correlating the quantitative measurements with the conventional visual scoring in test and control animals the value from a nearby control site was subtracted from the test site values. The correlations were highly significant (p less than 0.001-0.05) indicating that the quantitative methods were useful supplements to the visual scoring as a measure of interobserver and interlaboratory differences.
Relative efficiency of human Langerhans´ cells and blood derived dendritic cells as antigen-presenting cells
Authors: Bjercke S , Braathen L , Gaudernack G , Thorsby E.
Published: August 2023

T4 cells recognize antigens together with HLA class II molecules in the membrane of antigen-presenting cells (APC). The magnitude of the induced T cell response is in part dependent upon the APC´s amount of MHC-class II molecules. Langerhans´ dendritic cells (LC) express 50-100 times more HLA-DR molecules than monocytes (Mo) and blood derived dendritic cells (DC). We report here that LC are more efficient APC than DC from the same donor, indicating that the APC capacity of dendritic cells isolated from different organs is correlated to their expression of HLA class II gene products.
Candida albicans infections in leg ulcers and surrounding skin after the use of ointment impregnated stockings
Authors: Hansson C , Jekler J , Swanbeck G.
Published: August 2023

Six elderly women treated with double elastic bandages for chronic venous leg ulcers presented a clinical picture beneath these bandages as seen in intertriginous candidiasis. Painful, bright red, glistening skin lesions with pustules, denuded skin and scales were seen. Cultures on Sabouraud´s agar from skin erosions and toe webs confirmed the suspicion of Candida albicans infection. Treatment with topically applied clotrimazole cream resulted in relief of pain and healing of skin lesions. There is a possibility of the Candida albicans having been transmitted from the toe webs by the bandages, and that the bandages creates a microenvironment suitable for growth of the yeast.
Lupus erythematosus-like eruption from captopril
Authors: Patri P , Nigro A , Rebora A.
Published: August 2023

A patient on Captopril treatment is reported. This patient developed a dermatitis that clinically recalled a gyrate subacute lupus erythematosus and showed lichenoid features on light microscopy.
Recurrent cutaneous jellyfish eruptions without envenomation
Authors: Månsson T , Randle HW , Mandojana RM , Calton GJ , Burnett JW.
Published: August 2023

Three patients exhibiting recurrent cutaneous eruptions induced by contact with jellyfish tentacles are presented. The recurrent eruptions appeared several days after the primary exposure without contact with any offending coelenterate. The principal species involved include Pelagia noctiluca, Physalia physalis and probably Lychnorhiza lucerna. These three cases, combined with an earlier similar report of recurrent lesions induced by Physalia physalis suggest that this phenomenon may be widespread. In two of the three cases, the secondary eruption was more severe than that occurring after the primary envenomation.