bluuebunny/crossref_metadata_2025 huggingface dataset:
Pediatric Oncologists’ Experiences Returning and Incorporating Genomic Sequencing Results into Cancer Care
Authors: Hsu Rebecca L. , Gutierrez Amanda M. , Schellhammer Sophie K. , Robinson Jill O. , Scollon Sarah , Street Richard L. , Salisbury Alyssa N. , Pereira Stacey , Plon Sharon E. , Malek Janet , Parsons D. Williams , McGuire Amy L.
Published: June 2021

Pediatric oncologists’ perspectives around returning and incorporating tumor and germline genomic sequencing (GS) results into cancer care are not well-described. To inform optimization of cancer genomics communication, we assessed oncologists’ experiences with return of genomic results (ROR), including their preparation/readiness for ROR, collaboration with genetic counselors (GCs) during ROR, and perceived challenges. The BASIC3 study paired pediatric oncologists with GCs to return results to patients’ families. We thematically analyzed 24 interviews with 12 oncologists at two post-ROR time points. Oncologists found pre-ROR meetings with GCs and geneticists essential to interpreting patients’ reports and communicating results to families. Most oncologists took a collaborative ROR approach where they discussed tumor findings and GCs discussed germline findings. Oncologists perceived many roles for GCs during ROR, including answering families’ questions and describing information in lay language. Challenges identified included conveying uncertain information in accessible language, limits of oncologists’ genetics expertise, and navigating families’ emotional responses. Oncologists emphasized how GCs’ and geneticists’ support was essential to ROR, especially for germline findings. GS can be successfully integrated into cancer care, but to account for the GC shortage, alternative ROR models and access to genetics resources will be needed to better support families and avoid burdening oncologists.
Individual Revision Knee Arthroplasty Is a Safe Limb Salvage Procedure
Authors: Savov Peter , Tuecking Lars-Rene , Windhagen Henning , Ettinger Max
Published: June 2021

Introduction: Revision total knee arthroplasty after multiple pre-surgeries is challenging. Due to severe bone defects, standard implants for metaphyseal and diaphyseal anchoring may no longer be suitable. The primary aim of this case series is to evaluate the early complication rate for individual knee implants with custom-made cones and stems after two-stage revision with severe bone defects. Methods: Ten patients who were treated with custom-made 3D-printed knee revision implants were included. Inclusion criteria were a two-stage revision due to late-onset or chronic periprosthetic joint infection as well as aseptic loosening. All severe bone defects were AORI type III. All procedure-related complications were evaluated. Postoperative range of motion after one year was measured. The time between the two surgeries was evaluated. Results: The mean follow-up was 21 months (range: 12–40). The mean time between the two-stage surgeries was 71.6 days. No fractures were observed intra- and postoperatively. Two patients were revised without changing metal components due to persistent hematoma (three weeks post-surgery) and persistent PJI (three months post-surgery). The mean passive postoperative range of motion was 92° (range: 80–110°). Conclusions: Individual custom-made implants for rTKA provide a safe procedure for patients with huge bone defects after several pre-surgeries. If standard knee systems with standard cones or sleeves are not suitable anymore, custom-made treatment offers the patient the last option for limb preservation. However, this is associated with increased costs.
Time-Varying Nexus between Investor Sentiment and Cryptocurrency Market: New Insights from a Wavelet Coherence Framework
Authors: AlNemer Hashem A. , Hkiri Besma , Khan Muhammed Asif
Published: June 2021

This study attempts to investigate the nexus between investor sentiment and cryptocurrencies prices. Our empirical investigation merges bivariate and multivariate wavelet tools to examine the investor sentiment nexus to inter-cryptocurrencies prices. The study outcomes show that the Sentix Investor Confidence index provides significant information in explaining long-term changes in Bitcoin and Litecoin prices. Moreover, the findings generated from the multiple wavelet coherence illustrate the simultaneous contribution of cryptocurrencies and the Sentix Investor Confidence index in explaining the Bitcoin index movement across frequencies and over horizons, especially during bubble burst periods. The study also suggests a time-dependent relationship of Bitcoin prices with alternative cryptocurrencies and the Sentix Investor Confidence index, mostly pronounced during the Bitcoin bubble. We discuss our results using GSV-based investor sentiment. Our findings remain robust and confirm the strong predictive power of investor sentiment in cryptocurrencies price movements over time and across scales.
Prioritization of Sub-Watersheds to Sediment Yield and Evaluation of Best Management Practices in Highland Ethiopia, Finchaa Catchment
Authors: Dibaba Wakjira Takala , Demissie Tamene Adugna , Miegel Konrad
Published: June 2021

Excessive soil loss and sediment yield in the highlands of Ethiopia are the primary factors that accelerate the decline of land productivity, water resources, operation and function of existing water infrastructure, as well as soil and water management practices. This study was conducted at Finchaa catchment in the Upper Blue Nile basin of Ethiopia to estimate the rate of soil erosion and sediment loss and prioritize the most sensitive sub-watersheds using the Soil and Water Assessment Tool (SWAT) model. The SWAT model was calibrated and validated using the observed streamflow and sediment data. The average annual sediment yield (SY) in Finchaa catchment for the period 1990–2015 was 36.47 ton ha−1 yr−1 with the annual yield varying from negligible to about 107.2 ton ha−1 yr−1. Five sub-basins which account for about 24.83% of the area were predicted to suffer severely from soil erosion risks, with SY in excess of 50 ton ha−1 yr−1. Only 15.05% of the area within the tolerable rate of loss (below 11 ton ha−1yr−1) was considered as the least prioritized areas for maintenance of crop production. Despite the reasonable reduction of sediment yields by the management scenarios, the reduction by contour farming, slope terracing, zero free grazing and reforestation were still above the tolerable soil loss. Vegetative contour strips and soil bund were significant in reducing SY below the tolerable soil loss, which is equivalent to 63.9% and 64.8% reduction, respectively. In general, effective and sustainable soil erosion management requires not only prioritizations of the erosion hotspots but also prioritizations of the most effective management practices. We believe that the results provided new and updated insights that enable a proactive approach to preserve the soil and reduce land degradation risks that could allow resource regeneration.
Nature-Based Urbanization: Scan Opportunities, Determine Directions and Create Inspiring Ecologies
Authors: Roggema Rob , Tillie Nico , Keeffe Greg
Published: June 2021

To base urbanization on nature, inspiring ecologies are necessary. The concept of nature-based solutions (NBS) could be helpful in achieving this goal. State of the art urban planning starts from the aim to realize a (part of) a city, not to improve natural quality or increase biodiversity. The aim of this article is to introduce a planning approach that puts the ecological landscape first, before embedding urban development. This ambition is explored using three NBS frameworks as the input for a series of design workshops, which conceived a regional plan for the Western Sydney Parklands in Australia. From these frameworks, elements were derived at three abstraction levels as the input for the design process: envisioning a long-term future (scanning the opportunities), evaluating the benefits and disadvantages, and identifying a common direction for the design (determining directions), and implementing concrete spatial cross-cutting solutions (creating inspiring ecologies), ultimately resulting in a regional landscape-based plan. The findings of this research demonstrate that, at every abstraction, a specific outcome is found: a mapped ecological landscape showing the options for urbanization, formulating a food-forest strategy as the commonly found direction for the design, and a regional plan that builds from the landscape ecologies adding layers of productive ecologies and urban synergies. By using NBS-frameworks, the potentials of putting the ecological landscape first in the planning process is illuminated, and urbanization can become resilient and nature-inclusive. Future research should emphasize the balance that should be established between the NBS-frameworks and the design approach, as an overly technocratic and all-encompassing framework prevents the freedom of thought that is needed to come to fruitful design propositions.
Tracking Deformation Processes at the Legnica Glogow Copper District (Poland) by Satellite InSAR—II: Żelazny Most Tailings Dam
Authors: Mazzanti Paolo , Antonielli Benedetta , Sciortino Alessandra , Scancella Stefano , Bozzano Francesca
Published: June 2021

The failures of tailings dams have a major negative impact on the economy, surrounding properties, and people’s lives, and therefore the monitoring of these facilities is crucial to mitigate the risk of failure, but this can be challenging due to their size and inaccessibility. In this work, the deformation processes at Żelazny Most tailings dam (Poland) were analyzed using satellite Ad-vanced Differential SAR Interferometry (A-DInSAR) from October 2014 to April 2019, showing that the dam is affected by both settlements (with a maximum rate of 30 mm/yr), and horizontal sliding in radial direction with respect to the ponds. The load of the tailings is pushing the dam forward along the glacio-tectonic shear planes located at depth, in the Pliocene clays, causing horizontal displacements at a rate up to 30 mm/yr, which could lead to a passive failure of the dam. The measured displacements have been compared with the ones observed by in situ data from the 90s to 2013, available in the literature. The outcomes indicate that intense localized deformations occur in the eastern and northern sectors of the dam, while the western sector is deforming evenly. Moreover, although the horizontal deformation had a slowdown from 2010 until 2013, it continued in 2014 to 2019 with recovered intensity. The upper and the recent embankments are affected by major settlements, possibly due to a lower consolidation degree of the most recent tailings and a larger thickness of compressible materials.
Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review
Authors: de Matos Brenda Thaynne Lima , Buchaim Daniela Vieira , Pomini Karina Torres , Barbalho Sandra Maria , Guiguer Elen Landgraf , Reis Carlos Henrique Bertoni , Bueno Cleuber Rodrigo de Souza , Cunha Marcelo Rodrigues da , Pereira Eliana de Souza Bastos Mazuqueli , Buchaim Rogerio Leone
Published: June 2021

COVID-19 is a viral disease characterized as a pandemic by the World Health Organization in March 2020. Since then, researchers from all over the world have been looking for ways to fight this disease. Many cases of complications arise from insufficient immune responses due to low immunity, with intense release of pro-inflammatory cytokines that can damage the structure of organs such as the lung. Thus, the hypothesis arises that photobiomodulation therapy (PBMT) with the use of a low-level laser (LLLT) may be an ally approach to patients with COVID-19 since it is effective for increasing immunity, helping tissue repair, and reducing pro-inflammatory cytokines. This systematic review was performed with the use of PubMed/MEDLINE, Web of Science, Scopus and Google Scholar databases with the following keywords: “low-level laser therapy OR photobiomodulation therapy AND COVID-19”. The inclusion criteria were complete articles published from January 2020 to January 2021 in English. The exclusion criteria were other languages, editorials, reviews, brief communications, letters to the editor, comments, conference abstracts, and articles that did not provide the full text. The bibliographic search found 18 articles in the Pubmed/MEDLINE database, 118 articles on the Web of Science, 23 articles on Scopus, and 853 articles on Google Scholar. Ten articles were included for qualitative synthesis, of which four commentary articles discussed the pathogenesis and the effect of PBMT in COVID-19. Two in vitro and lab experiments showed the effect of PBMT on prevention of thrombosis and positive results in wound healing during viral infection, using the intravascular irradiation (ILIB) associated with Phthalomethyl D. Two case reports showed PBMT improved the respiratory indexes, radiological findings, and inflammatory markers in severe COVID-19 patients. One case series reported the clinical improvement after PBMT on 14 acute COVID-19 patients, rehabilitation on 24 patients, and as a preventive treatment on 70 people. One clinical trial of 30 patients with severe COVID-19 who require invasive mechanical ventilation, showed PBMT-static magnetic field was not statistically different from placebo for the length of stay in the Intensive Care Unit, but improved diaphragm muscle function and ventilation and decreased the inflammatory markers. This review suggests that PBMT may have a positive role in treatment of COVID-19. Still, the necessity for more clinical trials remains in this field and there is not sufficient research evidence regarding the effects of PBMT and COVID-19 disease, and there is a large gap.
Double Blind Peer-Review in Logistics
Authors: Handfield Robert
Published: June 2021

Pre-publication peer-review forms the basis for how scholarly journals assess whether an article is suitable for publication [...]
Evaluation of the Anticancer Activity of Phytomolecules Conjugated Gold Nanoparticles Synthesized by Aqueous Extracts of Zingiber officinale (Ginger) and Nigella sativa L. Seeds (Black Cumin)
Authors: Alkhathlan Alaa H. , Al-Abdulkarim Hessah A. , Khan Merajuddin , Khan Mujeeb , Alkholief Musaed , Alshamsan Aws , Almomen Aliyah , Albekairi Norah , Alkhathlan Hamad Z. , Siddiqui M. Rafiq H.
Published: June 2021

The conventional physical and chemical synthetic methods for the preparation of metal nanoparticles have disadvantages as they use expensive equipment and hazardous chemicals which limit their applications for biomedical purposes, and are not environment friendly. However, for the synthesis of biocompatible nanomaterials, plant-based techniques are eco-friendly and easy to handle. Herein a simple, single-step biosynthesis of gold nanoparticles using aqueous extracts of Nigella sativa (NSE) and Zingiber officinale (GE) as a reducing and capping agent has been demonstrated. The formation of gold nanoparticles (Au NPs) was confirmed by X-ray diffraction, UV-Vis, and EDS spectroscopies. Spectroscopic and chromatographic analysis of GE and NSE revealed the presence of bioactive phytochemical constituents, such as gingerol, thymoquinone, etc., which successfully conjugated the surface of resulting Au NPs. TEM analysis indicated the formation of smaller-sized, less-aggregated, spherical-shaped Au NPs both in the case of GE (~9 nm) and NSE (~11 nm). To study the effect of the concentration of the extracts on the quality of resulting NPs and their anticancer properties, three different samples of Au NPs were prepared from each extract by varying the concentration of extracts while keeping the amount of precursor constant. In both cases, high-quality, spherical-shaped NPs were obtained, only at a high concentration of the extract, whereas at lower concentrations, larger-sized, irregular-shaped NPs were formed. Furthermore, the as-prepared Au NPs were evaluated for the anticancer properties against two different cell lines including MDA-MB-231 (breast cancer) and HCT 116 (colorectal cancer) cell lines. GE-conjugated Au NPs obtained by using a high concentration of the extract demonstrated superior anticancer properties when compared to NSE-conjugated counterparts.
Laboratory Study on Improvement of Expansive Soil by Chemically Induced Calcium Carbonate Precipitation
Authors: Han Shaoyang , Wang Baotian , Gutierrez Marte , Shan Yibo , Zhang Yijiang
Published: June 2021

This paper proposes the use of calcium carbonate (CaCO3) precipitation induced by the addition of calcium chloride (CaCl2) and sodium carbonate (Na2CO3) solutions as a procedure to stabilize and improve expansive soil. A set of laboratory tests, including the free swell test, unloaded swelling ratio test, unconfined compression test, direct shear test, scanning electron microscopy (SEM) test, cyclic wetting–drying test and laboratory-scale precipitation model test, were performed under various curing periods to evaluate the performance of the CaCO3 stabilization. It is concluded from the free swell tests and unloaded swelling ratio tests that the addition of CaCl2 and Na2CO3 can profoundly decrease soil expansion potential. The reduction in expansion parameters is primarily attributed to the strong short-term reactions between clay and stabilizers. In addition, the formed cementation precipitation can decrease the water adsorption capacity of the clay surface and then consequently reduce the expansion potential. The results of unconfined compression tests and direct shear strength tests indicated that the addition of CaCl2 and Na2CO3 has a major effect on geotechnical behavior of expansive soils. Based on the SEM analyses, new cementing crystalline phases formatted by sequentially mixing CaCl2 and Na2CO3 solutions into expansive soil were found to appear in the pore space, which results in a much denser microstructure. A laboratory-scale model test was conducted, and results demonstrate the effectiveness of the CaCO3 precipitation technique in stabilizing the expansive soil procedure. The test results indicated that the concentration of CaCl2 higher than 22.0% and Na2CO3 higher than 21.2% are needed to satisfactorily stabilize expansive soil. It is proposed to implement the precipitation technique in the field by the sequential permeation of CaCl2 and Na2CO3 solutions into soils in situ.
Photothermal Killing of A549 Cells and Autophagy Induction by Bismuth Selenide Particles
Authors: You Yue , Li Jinxia , Chen Linlin , Wang Mei , Dong Xinghua , Yan Liang , Zhang Aiping , Zhao Feng
Published: June 2021

With a highly efficient optical absorption capability, bismuth selenide (Bi2Se3) can be used as an outstanding photothermal agent for anti-tumor treatment and shows promise in the field of nanotechnology-based biomedicine. However, little research has been completed on the relevant mechanism underlying the photothermal killing effect of Bi2Se3. Herein, the photothermal effects of Bi2Se3 particles on A549 cells were explored with emphasis put on autophagy. First, we characterized the structure and physicochemical property of the synthesized Bi2Se3 and confirmed their excellent photothermal conversion efficiency (35.72%), photostability, biocompatibility and ability of photothermal killing on A549 cells. Enhanced autophagy was detected in Bi2Se3-exposed cells under an 808 nm laser. Consistently, an elevated expression ratio of microtubule-associated protein 1 light chain 3-II (LC3-II) to LC3-I, a marker of autophagy occurrence, was induced in Bi2Se3-exposed cells upon near infrared (NIR) irradiation. Meanwhile, the expression of cleaved-PARP was increased in the irradiated cells dependently on the exposure concentrations of Bi2Se3 particles. Pharmacological inhibition of autophagy by 3-methyladenine (3-MA) further strengthened the photothermal killing effect of Bi2Se3. Meanwhile, stress-related signaling pathways, including p38 and stress activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), were activated, coupled with the attenuated PI3K/Akt signaling. Our study finds that autophagy and the activation of stress-related signaling pathways are involved in the photothermal killing of cancerous cells by Bi2Se3, which provides a more understanding of photothermal materials.
Influence of the Printing Angle and Load Direction on Flexure Strength in 3D Printed Materials for Provisional Dental Restorations
Authors: Derban Paula , Negrea Romeo , Rominu Mihai , Marsavina Liviu
Published: June 2021

The CAD/CAM techniques, especially additive manufacturing such as 3D printing, constitute an ever-growing part of obtaining different dental appliances and restorations. Of these, provisional restorations are of frequent use in daily dental practice and are the object of this study. Masticatory and parafunctional forces determine flexure on these prostheses. This study investigates the influence of the printing angle and loading direction of the applied force on the flexure strength of two commercially available printable resins—Detax Freeprint Temp and Nextdent MFH Vertex dental. Ten rectangular beam specimens printed at the angle of 0, 45 and 90 degrees were fabricated of each of these materials, with an addition of 10 at 0 degrees for the investigation of the load direction. Three-point bending tests were performed in a universal testing machine. Flexure strength, strain at break and Young’s modulus were determined and a statistical analysis was performed on the obtained data. According to the statistical analysis, the flexural strength has a significance dependence with respect to degrees of orientation, for both investigated materials.
Deformation Behavior and Tensile Properties of the Semi-Equiaxed Microstructure in Near Alpha Titanium Alloy
Authors: Luo Minglang , Lin Tingyi , Zhou Lei , Li Wei , Liang Yilong , Han Moliu , Liang Yu
Published: June 2021

The tensile deformation and fracture behavior of a particular semi-equiaxed microstructure (S-EM) in a near alpha titanium alloy TA19 are investigated by an in situ method. In the S-EM, the thin β lamellae grow through the equiaxed αp phase (αp), and the original αp/βtrans interface in the bimodal microstructure largely disappears, forming a blurry interface between the semi-equiaxed αp phase (equiaxed αp phase that is grew through by the thin β lamellae) and the transformed β microstructure (βtrans). The formation of dense slip bands inside the semi-equiaxed αp phase in the S-EM is inhibited by the thin β lamellae during the tensile deformation. The special characteristics of the S-EM reduce the stress concentration at the interface, and the crack initiation probability in the blurry semi-αp/βtrans interface decreased compared to the distinct αp/βtrans interface in a conventional equiaxed microstructure (EM). Moreover, the ultimate tensile strength of the S-EM is higher than that of the EM with a slight loss of plasticity.
New Benzo[h]quinolin-10-ol Derivatives as Co-sensitizers for DSSCs
Authors: Slodek Aneta , Gnida Paweł , Małecki Jan Grzegorz , Szafraniec-Gorol Grażyna , Chulkin Pavel , Vasylieva Marharyta , Nycz Jacek , Libera Marcin , Schab-Balcerzak Ewa
Published: June 2021

New benzo[h]quinolin-10-ol derivatives with one or two 2-cyanoacrylic acid units were synthesized with a good yield in a one-step condensation reaction. Chemical structure and purity were confirmed using NMR spectroscopy and elemental analysis, respectively. The investigation of their thermal, electrochemical and optical properties was carried out based on differential scanning calorimetry, cyclic voltammetry, electronic absorption and photoluminescence measurements. The analysis of the optical, electrochemical and properties was supported by density functional theory studies. The synthesized molecules were applied in dye-sensitized solar cells as sensitizers and co-sensitizers with commercial N719. The thickness and surface morphology of prepared photoanodes was studied using optical, scanning electron and atomic force microscopes. Due to the utilization of benzo[h]quinolin-10-ol derivatives as co-sensitizers, the better photovoltaic performance of fabricated devices compared to a reference cell based on a neat N719 was demonstrated. Additionally, the effect of co-adsorbent chemical structure (cholic acid, deoxycholic acid and chenodeoxycholic acid) on DSSC efficiency was explained based on the density functional theory.
Effect of VN and TiB2-TiCx Reinforcement on Wear Behavior of Al 7075-Based Composites
Authors: Bai Yaping , Wei Jiale , Lei Naqing , Li Jianping , Guo Yongchun , Liu Mengmeng
Published: June 2021

Al 7075 alloy, 15 wt.% VN/7075 composites, and 20 wt.% TiB2-TiCx/7075 composites were prepared by ball milling with subsequent hot-pressing sintering. The microstructure, hardness, and wear properties at room temperature to 200 °C of Al 7075-based composites with different reinforcement phases were discussed. The grain uniformity degree values of 15 wt.% VN/7075 composites and 20 wt.% TiB2-TiCx/7075 composites were 0.25 and 0.13, respectively. The reinforcement phase was uniformly distributed in 15 wt.% VN/7075 composites and 20 wt.% TiB2-TiCx/7075 composites, almost no agglomeration occurred. The order of hardness was 20 wt.% TiB2-TiCx/7075 composites (270.2 HV) > 15 wt.% VN/7075 composites (119.5 HV) > Al 7075 (81.8 HV). At the same temperature, the friction coefficient of 15 wt.% VN/7075 composites was the lowest, while the volume wear rate of 20 wt.% TiB2-TiCx/7075 composites was the lowest. With the increase of temperature, the wear mechanism of Al 7075 changed from spalling wear to oxidation wear and adhesion wear. However, the wear mechanisms of 15 wt.% VN/7075 and 20 wt.% TiB2-TiCx/7075 composites changed from abrasive wear at room temperature to wear mechanism (oxidation wear, abrasive wear, and adhesive wear) at medium and low temperature. Comprehensive wear test results indicated that 20 wt.% TiB2-TiCx/7075 composites had excellent tribological properties at medium and low temperature.
Frequency Measurement Method of Signals with Low Signal-to-Noise-Ratio Using Cross-Correlation
Authors: Liu Yang , Liu Jigou , Kennel Ralph
Published: June 2021

Precise frequency measurement plays an essential role in many industrial and robotic systems. However, different effects in the application’s environment cause signal noises, which make frequency measurement more difficult. In small signals or rough environments, even negative Signal-to-Noise Ratios (SNRs) are possible. Thus, frequency measuring methods, which are suited for low SNR signals, are in great demand. While denoising methods such as autocorrelation do not suffice for small signal with low SNR, frequency measurement methods such as Fast-Fourier Transformation or Continuous Wavelet Transformation suffer from Heisenberg’s uncertainty principle, which makes simultaneous high frequency and time resolutions impossible. In this paper, the cross-correlation spectrum is presented as a new frequency measuring method. It can be used in any frequency domain, and provides greater denoising than autocorrelation. Furthermore, frequency and time resolutions are independent from one another, and can be set separately by the user. In simulations, it achieves an average deviation of less than 0.1% on sinusoidal signals with a SNR of −10 dB and a signal length of 1000 data points. When applied to “self-mixing”-interferometry signals, the method can reach a normalized root-mean square error of 0.2% with the aid of an estimation method and an averaging algorithm. Therefore, further research of the method is recommended.
Dynamics under Uncertainty: Modeling Simulation and Complexity
Authors: Pamučar Dragan , Marinković Dragan , Kar Samarjit
Published: June 2021

This issue contains the successful invited submissions [...]
A Knowledge-Based Hybrid Approach on Particle Swarm Optimization Using Hidden Markov Models
Authors: Castillo Mauricio , Soto Ricardo , Crawford Broderick , Castro Carlos , Olivares Rodrigo
Published: June 2021

Bio-inspired computing is an engaging area of artificial intelligence which studies how natural phenomena provide a rich source of inspiration in the design of smart procedures able to become powerful algorithms. Many of these procedures have been successfully used in classification, prediction, and optimization problems. Swarm intelligence methods are a kind of bio-inspired algorithm that have been shown to be impressive optimization solvers for a long time. However, for these algorithms to reach their maximum performance, the proper setting of the initial parameters by an expert user is required. This task is extremely comprehensive and it must be done in a previous phase of the search process. Different online methods have been developed to support swarm intelligence techniques, however, this issue remains an open challenge. In this paper, we propose a hybrid approach that allows adjusting the parameters based on a state deducted by the swarm intelligence algorithm. The state deduction is determined by the classification of a chain of observations using the hidden Markov model. The results show that our proposal exhibits good performance compared to the original version.
Volatility Spillover Effect of Pan-Asia’s Property Portfolio Markets
Authors: Mata Mário Nuno , Najib Razali Muhammad , Bentes Sónia R. , Vieira Isabel
Published: June 2021

This study assesses the spillover effect of the listed property companies that cover pan-Asian countries, namely Malaysia, Thailand, Indonesia, Singapore, Vietnam, South Korea, Japan, China, the Philippines, and Hong Kong. The impact of market integration will create a spillover effect to the countries’ economic performances, in particular the property market. As macroeconomic factors have high correlation with the performance of property security markets, it is therefore important to study the spillover effect by integrating the macroeconomic factors. This study has employed the exponential generalised autoregressive conditional heteroscedasticity (EGARCH) technique to develop the volatility spillover effect among pan-Asian countries. The results reveal high volatility of listed property companies recorded in Hong Kong and China, while Singapore, The Philippines and Japan have shown low volatility spillovers. In terms of macroeconomic factors, gross domestic product (GDP) and money supply (MS) are the most significant factors in influencing the volatility spillover effect among pan-Asian countries. From the standpoint of regional investors, the volatility spillover characteristics of pan-Asian countries will aid property stakeholders in the region in developing their own methods for making investment decisions in the property security market. Furthermore, in uncertain conditions of the financial market, this study will elevate the transparency of the pan-Asian property portfolio market by providing information on the property market volatility spillovers.
A Refined Theory for Bending Vibratory Analysis of Thick Functionally Graded Beams
Authors: Boutahar Youssef , Lebaal Nadhir , Bassir David
Published: June 2021

A refined beam theory that takes the thickness-stretching into account is presented in this study for the bending vibratory behavior analysis of thick functionally graded (FG) beams. In this theory, the number of unknowns is reduced to four instead of five in the other approaches. Transverse displacement is expressed through a hyperbolic function and subdivided into bending, shear, and thickness-stretching components. The number of unknowns is reduced, which involves a decrease in the number of the governing equation. The boundary conditions at the top and bottom FG beam faces are satisfied without any shear correction factor. According to a distribution law, effective characteristics of FG beam material change continuously in the thickness direction depending on the constituent’s volume proportion. Equations of motion are obtained from Hamilton’s principle and are solved by assuming the Navier’s solution type, for the case of a supported FG beam that is transversely loaded. The numerical results obtained are exposed and analyzed in detail to verify the validity of the current theory and prove the influence of the material composition, geometry, and shear deformation on the vibratory responses of FG beams, showing the impact of normal deformation on these responses which is neglected in most of the beam theories. The obtained results are compared with those predicted by other beam theories. It can be concluded that the present theory is not only accurate but also simple in predicting the bending and free vibration responses of FG beams.
Pressure Oxidation of Arsenic (III) Ions in the H3AsO3-Fe2+-Cu2+-H2SO4 System
Authors: Karimov Kirill , Rogozhnikov Denis , Dizer Oleg , Tretiak Maksim , Mamyachenkov Sergey , Naboichenko Stanislav
Published: June 2021

The processing of low-grade polymetallic materials, such as copper–zinc, copper–lead–zinc, and poor arsenic-containing copper concentrates using hydrometallurgical methods is becoming increasingly important due to the depletion of rich and easily extracted mineral resources, as well as due to the need to reduce harmful emissions from metallurgy, especially given the high content of arsenic in ores. Ferric arsenates obtained through hydrothermal precipitation are the least soluble and most stable form of arsenic, which is essential for its disposal. This paper describes the investigation of the oxidation kinetics of As (III) ions to As (V) which is required for efficient purification of the resulting solutions and precipitation of low-solubility ferric arsenates. The effect of temperature (160–200 °C), the initial concentration of Fe (II) (3.6–89.5 mmol/dm3), Cu (II) (6.3–62.9 of mmol/dm3) and the oxygen pressure (0.2–0.5 MPa) on the oxidation efficiency of As (III) to As (V) was studied. As (III) oxidation in H3AsO-Fe2+-Cu2+-H2SO4 and H3AsO-Fe2+-H2SO4 systems was controlled by a chemical reaction with the apparent activation energy (Ea (≈84.3–86.3 kJ/mol)). The increase in the concentration of Fe (II) ions and addition of an external catalyst (Cu (II) ions) both have a positive effect on the process. When Cu (II) ions are introduced into the solution, their catalytic effect is confirmed by a decrease in the partial orders, Fe (II) ions concentration from 0.43 to 0.20, and the oxygen pressure from 0.95 to 0.69. The revealed catalytic effect is associated with a positive effect of Cu (II) ions on the oxidation of Fe (II) to Fe (III) ions, which further participate in As (III) oxidation. The semi-empirical equations describing the reaction rate under the studied conditions are written.
Characterisation of the Antibiotic Profile of Lysobacter capsici AZ78, an Effective Biological Control Agent of Plant Pathogenic Microorganisms
Authors: Brescia Francesca , Vlassi Anthi , Bejarano Ana , Seidl Bernard , Marchetti-Deschmann Martina , Schuhmacher Rainer , Puopolo Gerardo
Published: June 2021

Determining the mode of action of microbial biocontrol agents plays a key role in their development and registration as commercial biopesticides. The biocontrol rhizobacterium Lysobacter capsici AZ78 (AZ78) is able to inhibit a vast array of plant pathogenic oomycetes and Gram-positive bacteria due to the release of antimicrobial secondary metabolites. A combination of MALDI-qTOF-MSI and UHPLC-HRMS/M was applied to finely dissect the AZ78 metabolome and identify the main secondary metabolites involved in the inhibition of plant pathogenic microorganisms. Under nutritionally limited conditions, MALDI-qTOF-MSI revealed that AZ78 is able to release a relevant number of antimicrobial secondary metabolites belonging to the families of 2,5-diketopiperazines, cyclic lipodepsipeptides, macrolactones and macrolides. In vitro tests confirmed the presence of secondary metabolites toxic against Pythium ultimum and Rhodococcus fascians in AZ78 cell-free extracts. Subsequently, UHPLC-HRMS/MS was used to confirm the results achieved with MALDI-qTOF-MSI and investigate for further putative antimicrobial secondary metabolites known to be produced by Lysobacter spp. This technique confirmed the presence of several 2,5-diketopiperazines in AZ78 cell-free extracts and provided the first evidence of the production of the cyclic depsipeptide WAP-8294A2 in a member of L. capsici species. Moreover, UHPLC-HRMS/MS confirmed the presence of dihydromaltophilin/Heat Stable Antifungal Factor (HSAF) in AZ78 cell-free extracts. Due to the production of HSAF by AZ78, cell-free supernatants were effective in controlling Plasmopara viticola on grapevine leaf disks after exposure to high temperatures. Overall, our work determined the main secondary metabolites involved in the biocontrol activity of AZ78 against plant pathogenic oomycetes and Gram-positive bacteria. These results might be useful for the future development of this bacterial strain as the active ingredient of a microbial biopesticide that might contribute to a reduction in the chemical input in agriculture.
Hybrid Structures of Sisal Fiber Derived Interconnected Carbon Nanosheets/MoS2/Polyaniline as Advanced Electrode Materials in Lithium-Ion Batteries
Authors: Li Wei , Liu Yuanzhou , Zheng Shuang , Hu Guobin , Zhang Kaiyou , Luo Yuan , Qin Aimiao
Published: June 2021

In this work, we designed and successfully synthesized an interconnected carbon nanosheet/MoS2/polyaniline hybrid (ICN/MoS2/PANI) by combining the hydrothermal method and in situ chemical oxidative polymerization. The as-synthesized ICNs/MoS2/PANI hybrid showed a “caramel treat-like” architecture in which the sisal fiber derived ICNs were used as hosts to grow “follower-like” MoS2 nanostructures, and the PANI film was controllably grown on the surface of ICNs and MoS2. As a LIBs anode material, the ICN/MoS2/PANI electrode possesses excellent cycling performance, superior rate capability, and high reversible capacity. The reversible capacity retains 583 mA h/g after 400 cycles at a high current density of 2 A/g. The standout electrochemical performance of the ICN/MoS2/PANI electrode can be attributed to the synergistic effects of ICNs, MoS2 nanostructures, and PANI. The ICN framework can buffer the volume change of MoS2, facilitate electron transfer, and supply more lithium inset sites. The MoS2 nanostructures provide superior rate capability and reversible capacity, and the PANI coating can further buffer the volume change and facilitate electron transfer.
Effect of 1-Carbaldehyde-3,4-dimethoxyxanthone on Prostate and HPV-18 Positive Cervical Cancer Cell Lines and on Human THP-1 Macrophages
Authors: Medeiros Rui , Horta Bruno , Freitas-Silva Joana , Silva Jani , Dias Francisca , Sousa Emília , Pinto Madalena , Cerqueira Fátima
Published: June 2021

Xanthone derivatives have shown promising antitumor properties, and 1-carbaldehyde-3,4-dimethoxyxanthone (1) has recently emerged as a potent tumor cell growth inhibitor. In this study, its effect was evaluated (MTT viability assay) against a new panel of cancer cells, namely cervical cancer (HeLa), androgen-sensitive (LNCaP) and androgen-independent (PC-3) prostate cancer, and nonsolid tumor derived cancer (Jurkat) cell lines. The effect of xanthone 1 on macrophage functions was also evaluated. The effect of xanthone 1-conditioned THP-1 human macrophage supernatants on the metabolic viability of cervical and prostate cancer cell lines was determined along with its interference with cytokine expression characteristic of M1 profile (IL-1 ≤ β; TNF-α) or M2 profile (IL-10; TGF-β) (PCR and ELISA). Nitric oxide (NO) production by murine RAW264.7 macrophages was quantified by Griess reaction. Xanthone 1 (20 μM) strongly inhibited the metabolic activity of the cell lines and was significantly more active against prostate cell lines compared to HeLa (p < 0.05). Jurkat was the cell most sensitive to the effect of xanthone 1. Compound 1-conditioned IL-4-stimulated THP-1 macrophage supernatants significantly (p < 0.05) inhibited the metabolic activity of HeLa, LNCaP, and PC-3. Xanthone 1 did not significantly affect the expression of cytokines by THP-1 macrophages. The inhibiting effect of compound 1 observed on the production of NO by RAW 264.7 macrophages was moderate. In conclusion, 1-carbaldehyde-3,4-dimethoxyxanthone (1) decreases the metabolic activity of cancer cells and seems to be able to modulate macrophage functions.
Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors
Authors: Behl Tapan , Kaur Dapinder , Sehgal Aayush , Singh Sukhbir , Sharma Neelam , Zengin Gokhan , Andronie-Cioara Felicia Liana , Toma Mirela Marioara , Bungau Simona , Bumbu Adrian Gheorghe
Published: June 2021

Despite not being utilized as considerably as other antidepressants in the therapy of depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in neurodegeneration and to have a somewhat broad spectrum in respect of the treatment of neurological and psychiatric conditions. Preclinical and clinical studies on MAOIs have been developing in recent times, especially on account of rousing discoveries manifesting that these drugs possess neuroprotective activities. The altered brain levels of monoamine neurotransmitters due to monoamine oxidase (MAO) are directly associated with various neuropsychiatric conditions like Alzheimer’s disease (AD). Activated MAO induces the amyloid-beta (Aβ) deposition via abnormal cleavage of the amyloid precursor protein (APP). Additionally, activated MAO contributes to the generation of neurofibrillary tangles and cognitive impairment due to neuronal loss. No matter the attention of researchers on the participation of MAOIs in neuroprotection has been on monoamine oxidase-B (MAO-B) inhibitors, there is a developing frame of proof indicating that monoamine oxidase-A (MAO-A) inhibitors may also play a role in neuroprotection. The therapeutic potential of MAOIs alongside the complete understanding of the enzyme’s physiology may lead to the future advancement of these drugs.
Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in Hawaii
Authors: Yamanaka Hunter R. , Cheung Cynthia , Mendoza Jireh S. , Oliva Danson J. , Elzey-Aberilla Kealina , Perrault Katelynn A.
Published: June 2021

Fast diagnostic results using breath analysis are an anticipated possibility for disease diagnosis or general health screenings. Tests that do not require sending specimens to medical laboratories possess capabilities to speed patient diagnosis and protect both patient and healthcare staff from unnecessary prolonged exposure. The objective of this work was to develop testing procedures on an initial healthy subject cohort in Hawaii to act as a range-finding pilot study for characterizing the baseline of exhaled breath prior to further research. Using comprehensive two-dimensional gas chromatography (GC×GC), this study analyzed exhaled breath from a healthy adult population in Hawaii to profile the range of different volatile organic compounds (VOCs) and survey Hawaii-specific differences. The most consistently reported compounds in the breath profile of individuals were acetic acid, dimethoxymethane, benzoic acid methyl ester, and n-hexane. In comparison to other breathprinting studies, the list of compounds discovered was representative of control cohorts. This must be considered when implementing proposed breath diagnostics in new locations with increased interpersonal variation due to diversity. Further studies on larger numbers of subjects over longer periods of time will provide additional foundational data on baseline breath VOC profiles of control populations for comparison to disease-positive cohorts.
Artificial Neural Networks for Pyrolysis, Thermal Analysis, and Thermokinetic Studies: The Status Quo
Authors: Muravyev Nikita V. , Luciano Giorgio , Ornaghi Heitor Luiz , Svoboda Roman , Vyazovkin Sergey
Published: June 2021

Artificial neural networks (ANNs) are a method of machine learning (ML) that is now widely used in physics, chemistry, and material science. ANN can learn from data to identify nonlinear trends and give accurate predictions. ML methods, and ANNs in particular, have already demonstrated their worth in solving various chemical engineering problems, but applications in pyrolysis, thermal analysis, and, especially, thermokinetic studies are still in an initiatory stage. The present article gives a critical overview and summary of the available literature on applying ANNs in the field of pyrolysis, thermal analysis, and thermokinetic studies. More than 100 papers from these research areas are surveyed. Some approaches from the broad field of chemical engineering are discussed as the venues for possible transfer to the field of pyrolysis and thermal analysis studies in general. It is stressed that the current thermokinetic applications of ANNs are yet to evolve significantly to reach the capabilities of the existing isoconversional and model-fitting methods.
The Concept of Folic Acid in Health and Disease
Authors: Shulpekova Yulia , Nechaev Vladimir , Kardasheva Svetlana , Sedova Alla , Kurbatova Anastasia , Bueverova Elena , Kopylov Arthur , Malsagova Kristina , Dlamini Jabulani Clement , Ivashkin Vladimir
Published: June 2021

Folates have a pterine core structure and high metabolic activity due to their ability to accept electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential one-carbon pathways donating methyl-groups to choline phospholipids, creatine, epinephrine, DNA. Compounds similar to folates are ubiquitous and have been found in different animals, plants, and microorganisms. Folates enter the body from the diet and are also synthesized by intestinal bacteria with consequent adsorption from the colon. Three types of folate and antifolate cellular transporters have been found, differing in tissue localization, substrate affinity, type of transferring, and optimal pH for function. Laboratory criteria of folate deficiency are accepted by WHO. Severe folate deficiencies, manifesting in early life, are seen in hereditary folate malabsorption and cerebral folate deficiency. Acquired folate deficiency is quite common and is associated with poor diet and malabsorption, alcohol consumption, obesity, and kidney failure. Given the observational data that folates have a protective effect against neural tube defects, ischemic events, and cancer, food folic acid fortification was introduced in many countries. However, high physiological folate concentrations and folate overload may increase the risk of impaired brain development in embryogenesis and possess a growth advantage for precancerous altered cells.
Use of Silicon Nanowire Sensors for Early Cancer Diagnosis
Authors: Ivanov Yuri D. , Romanova Tatyana S. , Malsagova Kristina A. , Pleshakova Tatyana O. , Archakov Alexander I.
Published: June 2021

The review covers some research conducted in the field of medical and biomedical application of devices based on silicon sensor elements (Si-NW-sensors). The use of Si-NW-sensors is one of the key methods used in a whole range of healthcare fields. Their biomedical use is among the most important ones as they offer opportunities for early diagnosis of oncological pathologies, for monitoring the prescribed therapy and for improving the people’s quality of life.