bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Two Different Accesses Single Orifice Percutaneous Endoscopic Surgery in Diagnosis of Ascites of Unknown Origin: A Retrospective Study
Authors: Guo Li-liangzi , Wu Ben-hua , Yu Zhi-Chao , Luo Ming-han , Li Feng , Xiong Feng , Wei Cheng , Shi Rui-yue , Liu Ting-ting , Zhang Ding-guo , Li De-feng , Xu Zheng-lei , Zhu Hui-ming , Wang Li-sheng , Yao Jun
Published: April 2022

Background. Ascites is a common clinical finding caused by many different diseases, so we developed a technique termed single orifice percutaneous endoscopic surgery (SOPES) which can access peritoneal cavity through the contralateral McBurney’s point or umbilicus to seek the underlying causes. In this study, we describe the initial clinical experience of SOPES and compare the application of two accesses. Methods. This is a retrospective study performed between 2007 and 2018. Patients with ascites of unknown origin who underwent these two kinds of SOPES were included. Main outcomes were measured by diagnostic accuracy, complication rate, procedure time, time till stitches removal, length of hospital stay, and hospital cost. Results. 148 patients successfully undergone SOPES via the contralateral McBurney’s point (IM group,

n
=
70

) or the umbilicus (UM group,

n
=
78

). 63 patients in the IM group and 71 patients in the UM group reached clear diagnosis (90.0% vs. 91.0%,

p
=
0.831

). The overall complication rate was 5.4%, while the UM group was higher than the IM group (10.3% vs. 0%,

p
=
0.017

). All complications were resolved after medical treatment, and no mortality resulted from this procedure. The procedure time and the time until stitches removal in the UM group were longer than that in the IM group. There were no significant differences in length of hospital stay and hospital cost between the two groups. Conclusions. SOPES, which combines the strength of minimally invasive single orifice incision and flexible angles of examination and instrumentation, is a newly developed flexible endoscopic surgical modality that provides new important clinical valuable in evaluation of ascites of unknown origin. Moreover, SOPES via the contralateral McBurney’s point was safer than the umbilicus approach.
Iopromide and Iodixanol in the Development of Postoperative Contrast Nephropathy in Patients with Renal Insufficiency: A Meta-Analysis
Authors: Feng Yiyu , Qiu Guoping , Xu Chengyun , Duan Zhibing , Wang Manting , Wang Lamei , Hu Wenjie , Li Peifang , Zhou Hui
Published: April 2022

In order to compare the effects of iopromide and isoxazole on postoperative contrast-induced nephropathy in patients with renal insufficiency, the paper searches for randomized controlled trials and retrospective cohort studies comparing the effects of iopromide and iodixanol on renal function in patients with renal insufficiency after surgery. The data are extracted from eligible studies. We tried to assess the incidence of contrast-agent nephropathy, preoperative and postoperative serum creatinine indicators, and mortality. This paper includes 8 studies with a total of 1243 patients. The incidence of contrast-induced nephropathy in the iopromide group is higher than that in the iodixanol group, and there is no significant difference between the two groups in postoperative mortality and preoperative serum creatinine expression. Sensitivity analysis and funnel chart show that our research is robust and has low publication bias. Our research shows that in patients with renal insufficiency, the incidence of contrast-medium nephropathy in the iopromide group is higher than that in the iodixanol group. Iodixanol is safer and has less effect on patients’ serum creatinine levels.
Impact of Placement of Aminopropyl Triethoxy Silane and Tetraethoxy Silicate on SSBR Chains: Analysis of Rolling Resistance, Wet Grip, and Abrasion Resistance
Authors: Hassanabadi Majid , Najafi Mohammad , Nikazar Sohrab , Garakani Sadaf Saeedi , Motlagh Ghodratollah Hashemi
Published: April 2022

Solution styrene-butadiene rubber (SBR) and silica filler have attracted a significant attention because of their superior properties in cured rubber mixtures used in automobile tire industry. One of the challenges ahead of using these materials is the hard dispersion of silica with its polar surface in SBR nonpolar rubber. In the present study, the synthesis of styrene-butadiene rubber by solution polymerization method with polymer chain modification using copolymer functionalization was performed. For this purpose, two materials, namely, aminopropyl triethoxy silane (APTES) and tetraethoxy silicate (TEOS), were employed to improve the silica dispersion in the mixture. The results of postsynthesis structural tests show the successful placement of functional groups on the polymer chain. The results of mechanical, dynamic, and imaging analyses of the cured mixtures showed an improvement in the APTES-containing samples rolling resistance, wet surface grip, and abrasion resistance by 39%, 18%, and 17%, respectively, due to having stronger physical and chemical bonds with silica and also the usage of end agents in the polymer chain. The samples containing TEOS had also better results than the conventional SBR rubber. In addition, a sample containing emulsion styrene-butadiene rubber was prepared to compare its properties with those of the solution SBR. Another SBR sample containing silane coupling agent was also prepared to investigate its performance compared to that of the agents placed on the polymer chain. The abrasion resistance, rolling resistance, and wet grip of the coupling agent containing sample showed 2%, 10%, and 30% improvement, respectively, which were very close to those of the sample containing the TEOS agent. In this work, various techniques including, rheometry, wear, rolling, hardness, bound rubber content, dynamic mechanical thermal analysis (DMTA), and field emission scanning electron microscopy (FE-SEM) were employed to analyze the synthesized rubber.
Identification of Key CircRNAs Related to Pulmonary Tuberculosis Based on Bioinformatics Analysis
Authors: Yuan Qin , Wen Zilu , Yang Ke , Zhang Shulin , Zhang Ning , Song Yanzheng , Chen Fuxue
Published: April 2022

Pulmonary tuberculosis (TB) is a chronic infectious disease that is caused by respiratory infections, principally Mycobacterium tuberculosis. Increasingly, studies have shown that circular (circ)RNAs play regulatory roles in different diseases through different mechanisms. However, their roles and potential regulatory mechanisms in pulmonary TB remain unclear. In this study, we analyzed circRNA sequencing data from adjacent normal and diseased tissues from pulmonary TB patients and analyzed the differentially expressed genes. We then constructed machine learning models and used single‐factor analysis to identify hub circRNAs. We downloaded the pulmonary TB micro (mi)RNA (GSE29190) and mRNA (GSE83456) gene expression datasets from the Gene Expression Omnibus database and performed differential expression analysis to determine the differentially expressed miRNAs and mRNAs. We also constructed a circRNA–miRNA–mRNA interaction network using Cytoscape. Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were used to predict the biological functions of the identified RNAs and determine hub genes. Then, the STRING database and cytoHubba were used to construct protein‐protein interaction networks. The results showed 125 differentially expressed circRNAs in the adjacent normal and diseased tissues of pulmonary TB patients. Among them, we identified three hub genes associated with the development of pulmonary TB: hsa_circ_0007919 (upregulated), hsa_circ_0002419 (downregulated), and hsa_circ_0005521 (downregulated). Through further screening, we determined 16 mRNAs of potential downstream genes for hsa‐miR‐409‐5p and hsa_circ_0005521 and established an interaction network. This network may have important roles in the occurrence and development of pulmonary TB. We constructed a model with 100% prediction accuracy by machine learning and single‐factor analysis. We constructed a protein‐protein interaction network among the top 50 hub mRNAs, with FBXW7 scoring the highest and SOCS3 the second highest. These results may provide a new reference for the identification of candidate markers for the early diagnosis and treatment of pulmonary TB.
Multiconstraint-Oriented Tactical Communication Network Planning Problem
Authors: Liu Dian , Liu XiangWei , Ma CunLai
Published: April 2022

Based on the complex network theory, this paper comprehensively studies the equipment and its interrelationship in the tactical communication system and constructs a system networking model. Based on the analysis of the structure and organizational application of the tactical communication system, this paper provides an appropriate mathematical description of its net-electric attack strategy and evaluation. A network simulation test model of tactical communication system was established, and then, by changing the network structure of the tactical communication system, such as the number of nodes, the nature of links, and the conditions of the net-electric attack, changes in combat capabilities were observed, and the impact of equipment deployment and communication organization methods on the system was analyzed, and finally, reliability evaluation and optimization analysis were conducted.
Autophagy Ameliorates Reactive Oxygen Species-Induced Platelet Storage Lesions
Authors: Zhao Xi , Zhao Yangchao , Ding Yanzhong , Ruan Yongjuan , Li Xiaowei , Zhou Qi , Zhou Yangfan , Zhang Chunyang , Hu Liang , Zhao Xiaoyan , Liu Yangyang
Published: April 2022

Platelet transfusion is a life-saving therapy to prevent bleeding; however, the availability of platelets for transfusion is limited by the markedly short shelf life owing to the development of platelet storage lesions (PSLs). The mechanism of PSLs remains obscure. Dissection of the intracellular biological changes in stored platelets may help to reduce PSLs and improve platelet transfusion efficiency. In the present study, we explore the changes of stored platelets at room temperature under constant agitation. We found that platelets during storage showed an increased reactive oxygen species (ROS) generation accompanied with receptor shedding, apoptosis, and diminished platelet aggregation. ROS scavenger reduced platelet shedding but also impaired platelet aggregation. Autophagy is a conserved catabolic process that sequesters protein aggregates and damaged organelles into lysosomes for degradation and platelets’ own intact autophagic system. We revealed that there exist a stable autophagic flux in platelets at the early stage of storage, and the autophagic flux in platelets perished after long-term storage. Treatment stored platelets with rapamycin, which stimulates autophagy in eukaryotic cells, markedly ameliorated PSLs, and improved platelet aggregation in response to extracellular stimuli.
Effects of Cisplatin Combined with Metformin on Proliferation and Apoptosis of Nasopharyngeal Carcinoma Cells
Authors: Shi Ling , Mei Yaoguo , Duan Xunhuang , Wang Bo
Published: April 2022

Background. Nasopharyngeal carcinoma (NPC) is an invasive squamous cell carcinoma located in the nasopharynx. NPC has a high recurrence risk after initial treatment due to its high metastatic and immune escape potential. One study has found that metformin can improve cancer outcomes and reduce cancer incidence. Objective. With antitumor activity, metformin can have low toxicity when used in combination with some common chemotherapy drugs. This study was designed to explore the effects of cisplatin combined with metformin on the proliferation and apoptosis of nasopharyngeal carcinoma (NPC) cells. Methods. An appropriate cisplatin concentration was selected for NPC cells, and the cells were treated with metformin at a gradient concentration, and then, some of them were treated with cisplatin. Subsequently, the biological effects (activity, migration, invasion, and apoptosis) of metformin alone and metformin combined with cisplatin on NPC cells were evaluated. Results. Metformin alone inhibited cell activity, migration, and invasion and promoted cell apoptosis in a concentration-dependent and time-dependent manner, while compared with cisplatin alone, cisplatin combined with metformin had stronger inhibition on cell activity, migration, and invasion and stronger induction to cell apoptosis, and a higher concentration of them demonstrated stronger effects. Conclusion. Cisplatin combined with metformin can strongly inhibit the activity of NPC cells and promote their apoptosis.
An Investigation of Flipping an English Reading Course: Focus on Reading Gains and Anxiety
Authors: Mohammaddokht Farnoosh , Fathi Jalil
Published: April 2022

The aim of this research was to explore the effect of flipped classroom on English as a Foreign Language (EFL) learners’ reading skill and reading anxiety. For this purpose, a sample of 44 Iranian EFL learners was recruited and randomly assigned to a flipped group (N =23) and a non-flipped group (N =21). Using a quasi-experimental design, the researchers employed an experimental group that received flipped instruction and a control group that were instructed based on the regular method for a period of four months. The reading component of the Cambridge Preliminary English Test (CPET) and a scale of reading anxiety were given to assess the reading comprehension and reading anxiety of the participants as pre-test and post-test of the study. The outcomes of the research indicated that the learners in the flipped class substantially performed better than those of the non-flipped class regarding EFL reading gains. Also, flipping the course significantly reduced reading anxiety of the participants. According to these results, it may be concluded that EFL teachers can utilize flipped instruction for their reading courses.
The Boundedness of Doob’s Maximal and Fractional Integral Operators for Generalized Grand Morrey-Martingale Spaces
Authors: Li Libo , Hao Zhiwei , Ding Xinru
Published: April 2022

In this paper, we introduce the generalized grand Morrey spaces in the framework of probability space setting in the spirit of the martingale theory and grand Morrey spaces. The Doob maximal inequalities on the generalized grand Morrey spaces are provided. Moreover, we present the boundedness of fractional integral operators for regular martingales in this new framework.
Study on the Safety of the New Radial Artery Hemostasis Device
Authors: Wu Baofeng , Zhang Ruixin , Liang Chendi , Zhang Chengjie , Qin Gang
Published: April 2022

Objective. At present, the use of particular radial hemostatic devices after coronary angiography (CAG) or percutaneous coronary intervention (PCI) has become the primary method of hemostasis. Most control studies are based on the products already on the market, while only a few studies are on the new hemostatic devices. The aim of this study is to compare a new radial artery hemostasis device which is transformed based on the invention patent (Application number: CN201510275446) with TR Band (Terumo Medical) to evaluate its clinical effects. Methods. In a prospective randomized clinical trial, 60 patients after CAG or PCI were randomly divided into two groups, patients in the trial group (CD group) using a new radial artery hemostasis device to stop bleeding and the control group (TR group) using the TR Band. The method is to collect relevant data of the two groups and compare the differences in hemostasis, local complications, and patient discomfort between the two groups. Results. The hemostatic devices in both groups achieved adequate hemostasis, and there was no failure to stop bleeding. The new radial artery hemostasis device was better than the TR band in pain and swelling (

P
<
0.05

). There were no significant differences in bleeding, hematoma, ecchymosis, skin damage, and local infection between the two groups (

P
>
0.05

). Conclusions. The sample of the new radial artery hemostasis device can stop bleeding effectively at the puncture site after CAG or PCI and is not inferior to the TR Band balloon hemostatic device in safety and is better in comfort.
Psychotherapy Combined with Western Medicine in the Treatment of Children with Tic Disorder: Systematic Review and Meta-Analysis
Authors: Kong Yamin , Zhang Xueyuan , Ma Bingxiang
Published: April 2022

Objective. To evaluate the efficacy of psychotherapy in children with tic disorder and to provide basis for the application of psychotherapy in the treatment of children with tic disorder. Methods. A detailed search was conducted based on PubMed, Cochrane library database, CNKI, Wanfang Data, and VIP database to determine the randomized controlled trial (RCT) of psychotherapy combined with drugs and oral drugs in the treatment of tic disorder. The search time was from the establishment of the database to August 20, 2021. All kinds of extracted data are meta analyzed, and the statistical software used is Review Manager 5.3 software. Results. According to the inclusion and exclusion criteria, 14 clinical trials were finally included, including 513 TD children, including 267 in the psychological intervention group and 246 in the control group. All trials were conducted in China and published from 2013 to 2021. In terms of clinical efficacy, compared with the control group, the psychotherapy combined with drugs group had more advantages in improving the effective rate (

RR
=
3.25

, 95% CI: 2.17~4.85,

Z
=
5.74

,

P
<
0.00001

) and improving the clinical symptoms of children with TD (

WM
=
−
5.36

, 95% CI: -6.41 ~ -4.30,

Z
=
9.97

,

P
<
0.00000
 
1

). Conclusion. Psychotherapy as an adjuvant therapy for clinical treatment of TD can improve the clinical efficacy, but due to the low methodological quality of the existing trials, the research may have potential bias. In the future, large sample, multicenter, and double-blind randomized controlled trials need to be carried out to provide further support.
Mechanical Mechanism Analysis of Roof Fracture Evolution in Stope with Variable Length Based on Elastic-Plastic Structure Theory
Authors: Wang Xinfeng , Lu Mingyuan , Wei Rui , Wang Zhaofeng , Li Shan
Published: April 2022

Stope with variable length is formed by length change of mining face due to the irregular distribution of geological rock pillars, which is a typical representative of complex coal seam mining. According to the geometric characteristics and mechanical boundaries of each mining stage of stope with variable length, the roof structure models with four boundary conditions were established and solved successively by using the small deflection thin plate bending theory. Combined with the simulated images of MATLAB and FLAC3D, the fracture laws and corresponding engineering phenomena were analyzed. According to the characteristics of roof rock pressure zoning, the overburden structure pressure model of “three stopes, three areas, and three structures” is constructed. The research shows that the traditional “O-X” fracture occurs in the roof of small mining stope. For the cracks generated by prolonged “O-X” fracture and drift “O-X” fracture in mutative mining stope are similar to the crack development characteristics of large mining stope, so they are integrated into full-scale mining stope. The full-scale mining stope roof is broken in “X-O” shape, and the crack continues to develop to produce extended fracture, forming the roof fracture theory of “two stopes and two laws.” The research conclusion strongly reveals the failure law of roof from tension instability to plastic fracture and abnormal ground pressure during mining in stope with variable length. It provides a basis for exploring the essence of overburden migration in stope with variable length and strengthening the roof prevention and control theory under the occurrence conditions of deep complex coal seams.
EFS-DNN: An Ensemble Feature Selection-Based Deep Learning Approach to Network Intrusion Detection System
Authors: Wang Zehong , Liu Jianhua , Sun Leyao
Published: April 2022

In recent years, the scale of networks has substantially evolved due to the rapid development of infrastructures in real networks. Under the circumstances, intrusion detection systems (IDSs) have become the crucial tool to detect cyberattacks, malicious actions, and anomaly behaviors that threaten the credibility and integrity of information services in networks. The feature selection technologies are commonly applied in various intrusion detection algorithms owing to the potential of improving performance and speeding up decision-making. However, existing feature selection-based intrusion detection methods still suffer from high computational complexity or the lack of robustness. To mitigate these challenges, we propose a novel ensemble feature selection-based deep neural network (EFS-DNN) to detect attacks in networks with high-volume traffic data. In particular, we leverage light gradient boosting machine (LightGBM) as the base selector in the ensemble feature selection module to enhance the robustness of the selected optimal subset. Besides, we utilize a deep neural network with batch normalization and embedding technique as the classifier to improve the expressiveness. We conduct extensive experiments on three public datasets to demonstrate the superiority of the EFS-DNN compared with baselines.
Feasibility of Transcatheter Closure of Large Secundum Atrial Septal Defect with Absent Superior or Inferior Rim
Authors: Abdulwahab Hussein , Husain Mohammed Rassul , Khalid Khalid A.
Published: April 2022

Introduction. Surgical closure of a large secundum atrial septal defect (ASD) with an absent superior or inferior rim is the standard method of management, but transcatheter closure of such a defect is possible and feasible. Objectives. To evaluate the feasibility, effectiveness, and safety of transcatheter closure of large secundum ASD with an absent superior or inferior rim through implantation of a cheatham platinum (CP) stent at the entrance of the superior vena cava (SVC) or inferior vena cava (IVC) into the right atrium (RA) to create a suitable rim for subsequent complete closure of the defect using a septal occluder. Patients and Methods. This case series was carried out at Ibn Al-Bitar Center for Cardiac Surgery, Baghdad, Iraq from 2014 to 2019, five patients underwent such transcatheter approach for closure of large secundum ASD with the absent superior or inferior rim by implantation of CP stent at the entrance of vena cave into the RA. Result. The ages and weights of patients who were enrolled in this study ranged from 9–31 years (15.2 ± 9 years) and 31.5–62 kg (42.6 ± 12 kg). Three patients had absent superior rims, and the other two had absent inferior rims. The Qp/Qs was ranged from 1.9–3.2 (2.78 ± 0.29), and the mean pulmonary arterial pressure ranged from 22–29 mmHg (25.4 ± 3 mmHg). The defects with an absent superior rim were closed successfully by implantation of CP stents of 45, 45, and 39 mm to create a rim which supported the left atrial disc of 30, 38, and 32 mm atrial septal occluder (ASO), respectively, while large secundum ASD with an absent inferior rim could be effectively closed by implantation of two overlapping bare CP stents of 45 mm to create an IVC rim that supported 34 mm and 30 mm atrial septal occluder. Conclusion and recommendation. Transcatheter closure of large secundum ASD with absent superior or inferior rim is possible and effective by implantation of covered and bare CP stents at the entrance of SVC and IVC, respectively. Although these procedures are relatively difficult and challenging, especially in the closure of large defects associated with absent inferior rim, they carry a high risk of stent migration (8 zig, 45 mm), so we recommend using a CP-stent (10 zig, 60 mm).
Investigation of Artery Wall Elasticity Effect on the Prediction of Atherosclerosis by Hemodynamic Factors
Authors: Kalbasi Rasool , Sharifzadeh Bahador , Jahangiri Mehdi
Published: April 2022

Atherosclerosis is a vascular disease in which some parts of the artery undergo stenosis due to the aggregation of fat. The causes and location of stenosis can be determined using fluid mechanics and parameters such as pressure, effective wall shear stress, and oscillatory shear index (OSI). The present study, for the first time, numerically investigates the pulsatile blood flow inside arteries with elastic and rigid walls in simple and double stenosis (80% stenosis) by using

k

-ω model and physiological pulse. The reason for applying the

k

-ω model in the present study was to provide more consistent results with clinical results to improve the accuracy in estimating atherosclerosis disease. The investigation of the time-mean wall shear stress indicated that for double stenosis, the difference between the results of the rigid and elastic artery assumptions is greater than the case of simple stenosis, so that this difference percent can be up to 2.5 times. In addition, the results showed that the pressure drop for the first stenosis is greater than the second stenosis, by 810 Pa (for solid artery) and 540 Pa (for elastic artery). The results also revealed that for simple stenosis, the length of the diseases prone zone in the elastic artery is 21% longer than the rigid one which this figure for double stenosis is calculated to be about 40%. Comparing the results of the simple stenosis with double, one affirmed that the artery wall thickness growth for case of double stenosis is greater than that of the single one.
Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells
Authors: Luo Haiyun , Zhou Yachuan , Liu Wenjing
Published: April 2022

Epigenetic regulation can dynamically adjust the gene expression program of cell fate decision according to the cellular microenvironment. Emerging studies have shown that metabolic activities provide fundamental components for epigenetic modifications and these metabolic-sensitive epigenetic events dramatically impact the cellular function of stem cells. Dental mesenchymal stem cells are promising adult stem cell resource for in situ injury repair and tissue engineering. In this review, we discuss the impact of metabolic fluctuations on epigenetic modifications in the oral and maxillofacial regions. The principles of the metabolic link to epigenetic modifications and the interaction between metabolite substrates and canonical epigenetic events in dental mesenchymal stem cells are summarized. The coordination between metabolic pathways and epigenetic events plays an important role in cellular progresses including differentiation, inflammatory responses, and aging. The metabolic-epigenetic network is critical for expanding our current understanding of tissue homeostasis and cell fate decision and for guiding potential therapeutic approaches in dental regeneration and infectious diseases.
Neurogenerative Disease Diagnosis in Cepstral Domain Using MFCC with Deep Learning
Authors: Alghamdi Norah Saleh , Zakariah Mohammed , Hoang Vinh Truong , Elahi Mohammad Mamun
Published: April 2022

Because underlying cognitive and neuromuscular activities regulate speech signals, biomarkers in the human voice can provide insight into neurological illnesses. Multiple motor and nonmotor aspects of neurologic voice disorders arise from an underlying neurologic condition such as Parkinson’s disease, multiple sclerosis, myasthenia gravis, or ALS. Voice problems can be caused by disorders that affect the corticospinal system, cerebellum, basal ganglia, and upper or lower motoneurons. According to a new study, voice pathology detection technologies can successfully aid in the assessment of voice irregularities and enable the early diagnosis of voice pathology. In this paper, we offer two deep-learning-based computational models, 1-dimensional convolutional neural network (1D CNN) and 2-dimensional convolutional neural network (2D CNN), that simultaneously detect voice pathologies caused by neurological illnesses or other causes. From the German corpus Saarbruecken Voice Database (SVD), we used voice recordings of sustained vowel /a/ generated at normal pitch. The collected voice signals are padded and segmented to maintain homogeneity and increase the number of samples. Convolutional layers are applied to raw data, and MFCC features are extracted in this project. Although the 1D CNN had the maximum accuracy of 93.11% on test data, model training produced overfitting and 2D CNN, which generalized the data better and had lower train and validation loss despite having an accuracy of 84.17% on test data. Also, 2D CNN outperforms state-of-the-art studies in the field, implying that a model trained on handcrafted features is better for speech processing than a model that extracts features directly.
Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway
Authors: Guo Fuding , Wang Yueyi , Wang Jun , Liu Zhihao , Lai Yanqiu , Zhou Zhen , Liu Zihan , Zhou Yuyang , Xu Xiao , Li Zeyan , Wang Meng , Yu Fu , Hu Ruijie , Zhou Liping , Jiang Hong
Published: April 2022

Choline is a precursor of the major neurotransmitter acetylcholine and has been demonstrated beneficial in diverse models of cardiovascular disease. Here, we sought to verify that choline protects the heart from DOX-induced cardiotoxicity and the underlying mechanisms. The results showed that DOX treatment decreased left ventricular ejection fraction and fractional shortening and increased serum cardiac markers and myocardial fibrosis, which were alleviated by cotreatment with choline. DOX-induced cardiotoxicity was accompanied by increases in oxidative stress, inflammation, and apoptosis, which were rectified by choline cotreatment. Levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme-oxygenase-1 (HO-1), which are antioxidant markers, were lowered by DOX and upregulated by choline. Moreover, DOX significantly decreased serum acetylcholine levels and the high-frequency component of heart rate variability and increased serum norepinephrine levels and the low-frequency component; these effects were rescued by choline administration. Interestingly, the protective effects of choline could be partially reversed by administration of the muscarinic receptor antagonist atropine. This suggests that choline might be a promising adjunct therapeutic agent to alleviate DOX-induced cardiotoxicity.
Using Kernel Method to Include Firm Correlation for Stock Price Prediction
Authors: Xu Hang
Published: April 2022

In this work, we propose AGKN (attention-based graph learning kernel network), a novel framework to incorporate information of correlated firms of a target stock for its price prediction in an end-to-end way. We first construct a stock-axis attention module to extract dynamic and asymmetric spatial correlations through the kernel method and a graph learning module into which more accurate information can be integrated. An ensemble time-axis attention module is then applied to learn temporal correlations within each stock and market index. Finally, we utilize a transformer encoder to jointly attend to obtain information from different levels for correlations’ aggregation and prediction. Experiments with data collected from the Chinese stock market show that AGKN outperforms state-of-the-art baseline methods, making up to 4.3% lower error than the best competitors. The ablation study shows that AGKN pays more attention to hidden correlation between stocks, which improves model’s performance greatly.
Long Noncoding RNA Hotair Promotes the Progression and Immune Escape in Laryngeal Squamous Cell Carcinoma through MicroRNA-30a/GRP78/PD-L1 Axis
Authors: Yuan Xiaowei , Shen Qinhua , Ma Wenxue
Published: April 2022

Homeobox (HOX) transcript antisense RNA (Hotair) is elevated in many cancers significantly. However, the oncogenic role of Hotair in human laryngeal squamous cell carcinoma (LSCC) is still unknown. Thus, we explored the expression profile of Hotair and its function in LSCC. We observed high expression levels of Hotair in six LSCC cell lines compared to the human nasopharyngeal epithelial cell line. Knockdown of Hotair inhibited proliferation and enhanced apoptosis of Tu212 and Hep-2 cell lines in vitro. Moreover, the overexpression of hsa-miR-30a-5p inhibited the expression of GRP78 and PD-L1, but Hotair overexpression in LSCC cells rescues both proteins. Furthermore, the impacts of hsa-miR-30a-5p upregulation on the apoptosis and proliferation of LSCC cells were rescued by overexpression of Hotair. Finally, we combined si-Hotair and a VEGF inhibitor to treat LSCC cells in vitro or in vivo and surprisingly observed a significant inhibition of LSCC growth. In summary, these results indicate that Hotair displays an oncogenic role in both malignancy and immune escape in LSCC related to hsa-miR-30a-5p/GRP78/PD-L1 signaling. Therefore, Hotair may be a potential target for treating LSCC.
[Retracted] A Retrospective Analysis of 1,595 Cases: Comparing the Characteristics of Total Knee Arthroplasty between Tibetans Living in the Plateau and Han of the Sichuan Basin
Authors: Guo Jing , Xu Qiang , Gao Menghui , Zhang Qingyan
Published: April 2022

Background. Total knee arthroplasty is an effective treatment for end‐stage knee arthritis. Studies’ date have shown that the demand for knee replacements continues to increase worldwide. Although racial disparities have been previously reported in the utilization of total knee arthroplasty in western countries, however, there are few similar studies in China. Objectives. Retrospective analysis of medical records identified the characteristics of Tibetan patients who had undergone total knee arthroplasty living in plateau and their differences with Hans living in Sichuan Basin. Methods. The patients with unilateral primary total knee arthroplasty in Sichuan Orthopedic Hospital from 2015 to 2020 were enrolled. Analyze and compare the demographic characteristics (age, body mass index, and occupation) and pathogenesis characteristics (disease duration, exacerbation period, treatment methods, etc.) of the plateau Tibetans and the Hans of the Sichuan Basin. Results. 1595 eligible patients were reviewed, including 541 Tibetan patients and 1054 Han patients, The average age of Tibetan patients was lower than that of Han patients (P < 0.001); the average BMI index of Tibetan patients was higher than that of Han patients (P < 0.001). And obese people account for more; the occupational distribution of Tibetan patients is more concentrated, mainly farmers. Tibetan patients have a longer course of disease than Han patients (P < 0.001). Conclusions. The social background and geographical environment of the Tibetan population are different from those of the Han. Tibetans living on plateaus have an earlier illness, a longer course of illness, a more obvious trend of younger, age and fewer opportunities for regular treatment during the illness.
The Effect of Freezing Twice during Assisted Reproductive Technology on Perinatal and Neonatal Outcomes
Authors: Pan Ye , Wu Richao , Wang Ze , Li Xiufang , Gao Shanshan , Shi Yuhua
Published: April 2022

Objective. The aim of this paper was to investigate whether two freeze‐thaw cycles before embryo transfer may affect perinatal and neonatal outcomes. Materials and Methods. A total of 8,028 frozen‐thawed embryo transfer patients who became pregnant between March 2013 and September 2019 were included. The patients were divided into two groups: the oocyte cryopreservation (OC) group (N = 96) and the control group (N = 7932). Propensity score matching (PSM) was used to adjust the baseline characteristics of the two groups at a proportion of 1 : 4. There were 96 patients in the OC group and 369 patients in the control group after PSM. The pregnancy‐related complications and neonatal conditions after delivery of the two groups were compared. Results. The OC group had a higher stillbirth rate (3.1% vs. 0.3%, P = 0.029) than the control group after PSM. Moreover, a slightly higher pregnancy defect rate was found in the OC group. There was no significant difference in the rates of diabetes mellitus, hypertension during pregnancy, cesarean section, multiple births, low birth weight (LBW), or premature birth defects between the two groups. Conclusions. Our findings demonstrate that performing frozen‐thawed embryo transfer (FET) with cryopreserved oocytes was associated with a higher rate of stillbirth than FET with fresh oocytes. The incidences of diabetes, gestational hypertension, cesarean section, multiple births, LBW, premature birth, and birth defects of the two groups were not significantly different.
Therapeutic Effects and Repair Mechanism of HGF Gene-Transfected Mesenchymal Stem Cells on Injured Endometrium
Authors: Xu Xuan , Xing Qiong , Liu Ruijun , Dong Liu , Yu Zhen , Wang Ying , Zhou Ping , Zhang Ying V. , Wang Jianye , Cao Yunxia , Wei Zhaolian
Published: April 2022

There are many studies on the advantages of using mesenchymal stem cells (MSCs) that secrete various paracrine factors for repairing endometrial injury. However, the stability and effectiveness of MSCs require improvement to become a viable therapy. Hepatocyte growth factor (HGF), one of the cytokines secreted by MSCs, promotes vascular repair and mesenchymal to epithelial transformation (MET). Therefore, HGF likely promotes the repair process of the endometrium. We prepared MSCs transfected with the HGF gene to explore its repair effects and mechanism using a damaged endometrium mouse model. HGF gene-transfected MSCs were prepared by electroporation. The transfected MSCs retained their cellular characteristics and significantly increased the expression of HGF (

P
<
0.01

). HGF gene-transfected MSCs helped damaged endometrium to recover its morphological characteristics, improved proliferation and decreased apoptosis of endometrial cells, increased the expression of endometrial vascular growth-related factors, and activated phosphorylated c-Met and AKT in the mouse endometrial damage model (

P
<
0.05

). Compared with normal MSCs, HGF gene-transfected MSCs produced a more significant effect on damaged endometrial epithelium repair by activating the HGF/c-Met and downstream signaling pathways. Our results indicate that HGF gene-transfected MSCs provide an effective and promising tool for injured endometrium therapy.
Intelligent Optimization Control Strategy for Secondary Pollution of Flue Gas in Municipal Solid Waste Incineration
Authors: Ju Yongsheng
Published: April 2022

Aiming at the problem of serious secondary pollution caused by improper control strategy in the waste incineration process, this paper proposes an intelligent optimization control strategy for secondary pollution of flue gas in municipal solid waste incineration. Firstly, the control difficulties of waste incineration and cybernetic characteristics of combustion process in incinerators are analyzed, and the basic algorithm based on human simulated intelligent control is proposed accordingly. Then, genetic algorithm is used to improve particle swarm algorithm and search ability in wide space, which can avoid the premature phenomenon of local optimum. Finally, improved particle swarm algorithm is utilized to optimize the parameters in human simulated intelligent control algorithm to realize intelligent optimization control in the waste incineration process. Based on MATLAB simulation platform, experimental results show that when delay parameters and time constant change significantly, there are large disturbances, and the process response of proposed strategy is fast and stable, which is superior to other comparison strategies.
MiR-300 Alleviates Cell Proliferation and Migration and Facilitates Cell Apoptosis by Targeting c-Met in Gastric Cancer
Authors: Wang Xiaoyan , He Lian , Wang Yan , Liu Yunyun , Wang Yuxin , Chen Dandan , Gong Dandan , Fan Yu
Published: April 2022

c-Met is a potent oncogene, whose aberrant activation has not been fully clarified. In this study, we discover the biological function of miR-300 in gastric cancer (GC) carcinogenesis and the underlying mechanism. The overexpression, oncogenic functions, and survival analysis of c-Met in GC tissues and cells were firstly determined. miRNAs that potentially targets c-Met were then predicted by bioinformatics. The expression levels of candidate miR-300 in GC tissue pairs were investigated. Pearson analysis revealed a negative relation between miR-300 and c-Met expressions. miR-300 and c-Met expression levels were determined in three GC cell lines (MKN-45, SGC-7901, and AGS) as well. Reduced miR-300 led to increase c-Met levels. Luciferase report assay demonstrated a direct binding site of miR-300 in the 3’ untranslated region (3

′

UTR) of c-Met. Finally, the regulatory role of miR-300 on MKN-45 cells was studied by cell proliferation, migration, and apoptosis assays. Overexpression of miR-300 attenuated viability and migration and accelerated apoptosis in MKN-45. We also induced a rescue experiment with c-Met overexpression plasmid and finally proved that miR-300 exerted a suppressing role on MKN-45 proliferation and migration but promoted MKN-45 apoptosis by directly inhibiting c-Met. This study provides a novel insight into the targeted drug development for GC therapies.
Two-Stage CNN Model for Joint Demosaicing and Denoising of Burst Bayer Images
Authors: Tan Hanlin , Xiao Huaxin , Liu Yu , Zhang Maojun
Published: April 2022

In the classical image processing pipeline, demosaicing and denoising are separated steps that may interfere with each other. Joint demosaicing and denoising utilizes the shared image prior information to guide the image recovery process. It is expected to have better performance by the joint optimization of the two problems. Besides, learning recovered images from burst (continuous exposure images) can further improve image details. This article proposes a two-stage convolutional neural network model for joint demosaicing and denoising of burst Bayer images. The proposed CNN model consists of a single-frame joint demosaicing and denoising module, a multiframe denoising module, and an optional noise estimation module. It requires a two-stage training scheme to ensure that the model converges to a good solution. Experiments on multiframe Bayer images with simulated Gaussian noise show that the proposed method has obvious performance advantages and speed advantages compared with similar approaches. Experiments on actual multiframe Bayer images verify the denoising effect and detail retention ability of the proposed method.
Intelligent Manufacturing of New Energy Vehicles and Financial Market Hedging Based on Soft Computing
Authors: Zhao Peizhi
Published: April 2022

Globally, the energy supply in the market is tight and the oil price fluctuates sharply. With the increasing degree of environmental pollution, both developed and developing countries pay special attention to the development of new energy, and energy conservation and emission reduction have been put on the agenda. As new energy vehicles have the advantages of energy conservation and environmental protection, they are strongly supported by governments. Many countries regard new energy vehicles as substitutes for traditional vehicles, and their development has ushered in a good opportunity. Under the background that the government and enterprises pay more attention to the development of new energy vehicles, it is of positive significance to study the intelligent manufacturing enterprises of new energy vehicles in a province. This paper studies the manufacturing of new energy vehicles through soft computing. Next, this paper also analyzes the financial market. Enterprise risk is closely related to investor income and social healthy development, which is a hot issue concerned by the public and the government. However, in recent years, there have been a series of cases in which enterprises have suffered huge losses using “hedging” to avoid operational risks, which has aroused public concern about the motivation of enterprises to use derivative financial products. Based on the leverage characteristics of derivative financial instruments, scholars believe that the high leverage profit in the capital market is the main incentive for enterprises to use hedging for hedging speculation. Existing studies pay more attention to the consequences of enterprise hedging, and they analyze the impact of enterprise hedging, focus on the result level after enterprise hedging, and seek the significance of enterprise hedging. Through the research on soft computing, this paper will apply it to the intelligent manufacturing of new energy vehicles and promote the development of hedging in China’s financial market
The Role of the P1 Latency in Auditory and Speech Performance Evaluation in Cochlear Implanted Children
Authors: Xiong Shan , Jiang Liwei , Wang Yu , Pan Tao , Ma Furong
Published: April 2022

Auditory deprivation affects normal age-related changes in the central auditory maturation. Cochlear implants (CIs) have already become the best treatment strategy for severe to profound hearing impairment. However, it is still hard to evaluate the speech-language outcomes of the pediatric CI recipients because of hearing-impaired children with limited speech-language abilities. The cortical auditory evoked potential (CAEP) provides a window into the development of the auditory cortical pathways. This preliminary study is aimed at assessing electrophysical characteristics of P1-N1 of electrically CAEP in children with CIs and at exploring whether these changes could be accounted for in auditory and speech outcomes of these patients. CAEP responses were recorded in 48 children with CIs in response to electrical stimulus to determine the presence of the P1-N1 response. Speech perception and speech intelligibility of the implanted children were further evaluated with the categories of auditory performance (CAP) test and speech intelligibility rating (SIR) test, respectively, to explore the relationship between the latency of P1-N1 and auditory and speech performance. This study found that P1 and N1 of the intracochlear CAEP were reliably evoked in children fitted with CIs and that the latency of the P1 as opposed to that of N1 was negative in relation to the wearing time of the cochlear implant. Moreover, the latency of the P1 produced significantly negative scores in both CAP and SIR tests, which indicates that P1 latency may be reflective of the auditory performance and speech intelligibility of pediatric CI recipients. These results suggest that the latency of P1 could be used for the objective assessment of auditory and speech function evaluation in cochlear-implanted children, which would be helpful in clinical decision-making regarding intervention for young hearing-impaired children.
A Novel Link-Network Assignment to Improve the Performance of Mobility Management Protocols in Future Mobile Networks
Authors: Calle-Cancho Jesús , Carmona-Murillo Javier , González-Sánchez José-Luis , Cortés-Polo David
Published: April 2022

5G is expected to support new services and applications that will change the user experience and will drive to a new business landscape. Moreover, most of the services will require optimum connectivity and seamless mobility in heterogeneous networks. To cope with these challenges, network mobility management and network densification are envisioned to be key factors in the emerging 5G architectures. By deploying a large number of cells, 5G architectures can provide users with high throughput and flexible access services, an improvement of the network scalability and optimized network coverage. However, with this densification, seamless mobility support can lead to significant increasing in signaling overhead due to frequent handovers. In this context, network operators need to efficiently plan the deployment of the base stations taking into account the mobility management of the users, and the service degradation that this mobility process could cause. This article aims to optimize the assignment of the base stations to the access routers in the mobile network to improve the network performance. The results obtained show that our proposed Link-Network Assignment algorithm based on clustering techniques achieve significant gains in terms of signaling and data forwarding costs. These simulation results demonstrate that the proposed algorithm can successfully reduce signaling cost and packet delivery cost by up to 56% and 5%, respectively, on average, compared with baseline algorithms.