bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARATIVE ANALYSIS OF HAEMATOLOGICAL, IMMUNOHAEMATOLOGICAL PARAMETERS AND CLINICAL CHEMISTRY PROFILE AMONG LUPUS ANTICOAGULANT POSITIVE AND LUPUS ANTICOAGULANT NEGATIVE COVID-19 CASES
Authors: S H Talib , S R Bhattu , M S Chate
Published: May 2023

Introduction: Coronavirus disease 2019 (COVID-19) is characterised by a pro-coagulant state that can lead to
thromboembolic events. A high prevalence of Lupus Anti-coagulant has been shown in several studies, that may atleast
partially explain the procoagulant prole of COVID-19. Few people infected by Coronavirus have become seriously ill while others showed
little or no signs or symptoms related to COVID-19. This study was undertaken to analyze Haematological, Immunohaematological parameters
and clinical Chemistry prole among LA positive and LA negative COVID -19 cases.
Objectives:
1. To assess clinical, hematological and coagulation prole in COVID-19 lupus anticoagulant positive cases and lupus anticoagulant negative
cases ..
2. To correlate ndings amongst lupus anticoagulant positive and negative cases.
3. To assess inammatory status amongst Covid-19 lupus anticoagulant positive and negative cases with markers like Crp-q, LDH, D-Dimer and
Ferritin.
Materials and Methods: The study was conducted as a prospective observational study with search data forms from the case records of patients
hospitalized as ICU/ non- ICU COVID-19 cases in MGM Hospital and Medical College, Aurangabad during the pandemic for a total duration of
2 years from December 2020 to December 2022. A total of 90 patients with conrmed diagnosis of COVID-19 by RTPCR/RAT were studied. To
assess Lupus Anti-Coagulant positivity- Dilute Russel Viper venom time (DRVVT) technique is used for established COVID-19 cases
Conclusion: In conclusion, the current study conrmed no statistical correlation for parameters such as age, gender, comorbidities
(hypertension, diabetes mellitus, COPD, IHD) in LA positive and LA negative cases. There was no statistical correlation found for ANA, RA
factor, Inammatory markers and Coagulation prole among LA positive and LA negative cases. Neutrophil : Lymphocyte ratio and
Lymphocyte : CRP ratio did not statistically differ in LA positive and LA negative cases. Complications (stroke, IC bleed, DVT, PTE) were
observed in 16.27% LA negative patients while none of the above complications were seen in LA positive patients. Further large scale studies are
required to comment on differences in Haematological, Immunohaematological and Clinical Chemistry prole between LA positive and LA
negative cases.
AN INTERESTING CASE OF VARIANT COMMUNICATION IN THE NECK VEINS
Authors: K Shobha , R Shubha
Published: May 2023

The internal jugular vein is a signicant landmark encountered during central venous catheter insertion, and in various
surgical and radiological procedures in the neck. A good knowledge of the variations becomes essential to check any
inadvertent injury. The variant observed here includes the formation of a communication between the linguofacial trunk and anterior jugular vein.
A knowledge of all possible variants becomes clinically signicant at times when venous access is imperative and to the surgeon operating at this level.
THE PERSPECTIVE OF NURSING STAFF- FACTORS AFFECTING MEDICATION ERROR
Authors: Kaliyaperumal Raji , Raman Vinoth
Published: May 2023

One of the most frequent mistakes is medication administration error, which happens when the medication given to the
patient differs from the medication that was prescribed and administered by the staff nurses. The goal of this study was to
evaluate the variables that affect medication error. In this study, the factors associated with medication error were described using a crosssectional descriptive study methodology. The study was carried out in a chosen hospital in Coimbatore. The 150 staff nurses working in private
hospitals in Coimbatore were the study's target population. The participants were chosen using a practical sampling technique. 123 nurses who
work in the chosen hospitals made up the sample. The questionnaire used for the study had two sections. Section B includes nurse-related factors,
ward environments, management-related factors, and patient-related factors using a scale of Strongly Disagree=1 to Strongly Agree=5. Section A
contains demographic data (Age, Gender, Income, Working experience, Educational level, and Working area). Data was gathered using a Google
form and provided to the staff nurse by the nursing in-charge individual. According to the results, the management and patient-related component
had the greatest Grand Mean Value (3.87), followed by the ward-related factor (3.81), and the nurse-related factor (3.57). These drug mistakes
endangered the patient's health and put them at risk. To prevent medication errors, management should take action to address the issue and
maintain an appropriate nurse-to-patient ratio. This guarantees the patient's safety when seeking medical attention.
PROSPECTIVE STUDY TO EVALUATE FUNCTIONAL OUTCOME OF PAEDIATRIC RADIAL NECK FRACTURES TREATED BY METAIZEAU TECHNIQUE
Authors: Rochek Buragohain Chao , Mishra Kartikey , Dutta Nayanmoni , N.G Harikrishnan
Published: May 2023

Background: Radial neck fractures in children are a rare injury, and the timing of surgery as well as the surgical
technique will determine how well they respond to treatment. When the tilt surpasses 60 degrees, radial neck fractures in
children are signicant injuries with frequent after effects. In these situations, conservative treatment is frequently insufcient, and open
reduction may result in iatrogenic consequences. Retrograde intramedullary nailing of the radius is one method of treating dislocated radial neck
fractures in children (the Metaizeau technique). Aim: The purpose of this study was to evaluate the functional outcome of Metaizeau technique.
Methodology: After taking proper consent and ethical clearance a prospective study was conducted in 16 cases of closed radial neck fractures in
children aged 6-12 years without any neurovascular decit. Patients were treated by Metaizeau technique at Jorhat medical college and Hospital
from 2021-2022 and were followed up at 2 weeks, 4 weeks, 6 weeks, 10weeks and 12 weeks. Result: In this study, it is found that this technique is
safe and effective in treating radial neck fracture in children. The fracture should be reduced within 7 days of injury. Later on, fracture reduction
will be difcult because of brosis and fracture healing. In our study, average age was 9 years. Males were affected more than females and the
common mode of injury was fall on outstretched hand. All cases achieved radiological and clinical union by 6 weeks. All cases achieved
comparable exion-extension of elbow, supination-pronation of the forearm (as compared to healthy side). Average MEPS was 82.19 which was
quite remarkable. Only one patient developed entry site pressure necrosis by cut end of TENS nail. The other disadvantage of this technique was
need of second surgery for tens removal. Metaizeau technique is a minimally Conclusion: invasive technique with easy learning curve, minimal
tissue damage, and reduced chance of elbow stiffness and osteonecrosis of radial head. Our results are within the acceptable range of satisfactory
outcomes, if not more towards the better end of the outcomes quoted in literature.
HISTOMORPHOLOGICAL SPECTRUM OF OCULAR SURFACE SQUAMOUS NEOPLASIA: A 5 YEAR STUDY.
Authors: Kakumanu Richards , Fathima Neha , Swarajya Kumari K , Modini Modini
Published: May 2023

Ocular surface squamous neoplasia encompasses the entire spectrum of epithelial dysplasias and neoplasia
including squamous cell carcinoma. It may arise from ocular surface of conjunctiva, cornea and limbus.
Purpose: The aim of this study is to demonstrate varying degrees of histomorphological spectrum in Squamous neoplasias of ocular
surface. This is a Retrospective study conducted at Department Materials and Methods: of Pathology for a period of 5 years in
Sarojini devi eye Hospital, Hyderabad, Telangana, India. The data collected was subjected to statistical tabulations and analysis was
done. Results: The mean age of presentation was 46.39 years (6 to 82 years) with male preponderance (64.9%). The most common
age group of presentation was 31-40 years (n =31, 22.62%) .The most common type of OSSN was invasive Squamous cell carcinoma
seen in 37.22% (n =51) followed by Carcinoma in situ 20.43% (n =28). Out of 51 patients diagnosed with Squamous cell carcinoma,
male patients were 34 (66.6%) and female patients were 17 (33.3%), among females diagnosed with SCC 13 cases(76.7%) were well
differentiated type and remaining 4 cases(23.52) were moderately differentiated type. Only 1 male patient had Poorly differentiated
type of Squamous cell carcinoma, 3 patients (5.8%) had inltrating tumor into surrounding tissues. 7 Patients (5.10%) diagnosed with
OSSN were HIV positive. OSSN occurred in a relatively young Conclusion: age group with male preponderance possibly due to
outdoor exposure . Based on Histopathology, Squamous cell carcinoma is the most common form of OSSN in the Asian Indian
population.
DYGGVE-MELCHIOR-CLAUSEN SYNDROME-A CASE REPORT
Authors: G Maneesh , Neushree Neushree , Sarathi Vijay
Published: May 2023

We report a case of short stature and bony deformities. The child wasevaluated and differential diagnosis of
Pseudoachondroplasia, Morquio and Dyggve- Melchior- Clausen syndrome were considered. Conrmation of
thediagnosis was done by molecular genetic testing and required conrmation in the index case for planning further conception.This casereport
highlights the utility of molecular genetic testing in denitive diagnosis ofthe proband.
CLINICO-PATHOLOGICAL PROFILE OF BLADDER CANCER PATIENTS IN A TERTIARY CARE CENTRE.
Authors: Vaidya Kaustubh , Vijayanand Potdar Ojas , Charuchandra Bhide Prajakta , Vikram Patkar Amrita
Published: May 2023

Introduction: Bladder cancer (BC) is one of the most common urological malignancies.With Industrialisation, increasing exposure to
occupational hazards and ever increasing use of tobacco in various forms, more and more of these BCs are being diagnosed nowadays. Objectives
of the study: To study the clinical and histo-pathological prole of bladder cancer patients attending a tertiary care centre in Kerala in southern part
of india. Materials and methods: A prospective observational study of 90 patients with bladder cancer was conducted in department of Urology at
a tertiary care centre over a period of 1 year from Feb 2020 to Feb 2021. Patients presenting to department of urology, undergoing surgery for BC
were studied by demographic parameters (age,gender) detailed history, clinical examination, cystoscopy ndings and cytopathology results and
results analyzed. Results: A total of 90 patients were evaluated in the study. Highest number was found in patients of 60-80 years age group, with
males > females. Most patients presented with haematuria (88.89%), some with pain (18.89%) and irritative voiding complaints (12.22%) and
5.56% were incidental detection. Of all patients, 70% had history of smoking. Transitional Cell Carcinoma (TCC) was most common histology
found in 92.22% of study population followed by Adenocarcinoma (4.44%), Squamous cell carcinoma (2.22) and leiomyosarcoma(1.11%).
Among TCC, 54.22% had low grade, 33.73% were high grade and rest of them were PUNLUMP. Most of the lesions were unifocal polypoidal
growths. High grade cancers were found predominantly in patients with age>60 and history of tobacco smoking. Conclusion: Bladder cancer is
predominantly a disease of older men. High index of clinical suspicion, as well as thorough exploration of all possible epidemiological factors will
help clinician diagnose bladder malignancies. Awareness among the public should also be emphasized to make them understand the deleterious
consequences of exposure to risk factors like smoking.
SYSTEMATIC REVIEW ON MATERNAL POSITION AND MOBILITY DURING FIRST STAGE OF LABOR
Authors: Rathina N. , Srivastava Sunita , Dhiraj Sarita
Published: May 2023

This systematic review is the product of 10 top published journals. The search engines adopted in this study were PubMed, Medline, Cochrane Library, Google Scholar, and Research gate. The inclusion criteria were:1. Papers published between 2004-2020, 2. Top tier journal articles (High quality), 3. Term Mobility and rst stage of labor, duration of labor, Maternal and neonatal outcome. The present highlight is that the active phase of labor enhances the effect of gravity that helps the fetus to descend comfortably as there is adequate space to move downwards as the diameter of the pelvis expands to its maximum. The pressure on the nerve in the spine during labor is reduced and thus reducing and relieving pain. If the membranes are intact, the woman is allowed to walk about. This attitude prevents vena cava compression and encourages descent of the head. Ambulation can reduce the duration of labor, need for analgesia and improve maternal comfort. Mobilization improves frequency, strength and length of contractions, decreases the use of oxytocin to augment labor and improves oxygen supply to the fetus. It improves alignment of pelvic bones and the shape and capacity of pelvis, and optimizes the good t between fetus and pelvis. This paper shows the research gaps from different studies in the review of the literature. In this present study of systematic review, 10 recent multiple interventions based on RCTs and Non RCTs studies between 2004 to 2020 were systematically reviewed using the keywords search method. The ndings are discussed and research gaps are listed accordingly Systematic review on Mobility/Ambulation during the First Stage of Labor:
SERUM ELECTROLYTES AS A PROGNOSTIC MARKER IN ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Bhanu Rekha B. , Mounika A. , Kommanaboyina Puja
Published: May 2023

Background. COPD is the third leading cause of death. Activation of the renin-angiotensin-aldosterone system and inappropriately elevated plasma arginine vasopressin in COPD may cause hyponatremia. Hyponatremia in COPD may be a predictor of poor outcomes and patients may have high mortality. Hypokalemia in COPD may be attributed to respiratory acidosis, metabolic alkalosis, and long-standing steroid therapy. The use of beta 2 agonists may also contribute. Moreover, acute respiratory failure associated with hypokalemia may have poor outcomes Aim To compare the differences in respiratory parameters (ABG, Saturation at presentation, oxygen dependency), duration of stay, and mortality in AECOPD patients with and without dyselectrolytemia. Materials And Methods A retrospective observational study and case records of 100 patients who visited the hospital with AE of COPD from January 2019 to June 2022 were reviewed. Patients with dyselectrolytemia were considered as group I and patients without it were considered group II. Data regarding ABG, SPO2, oxygen dependency, duration of stay, mortality were collected and compared between the two groups Results And Conclusions Out of 100 patients, 60 were with dyselectrolytemia and 40 have normal electrolytes. In group, I patients 56.6% had acidotic pH (<7.35) (p=<0.007) and 83.3% had low saturation (p=0.05), 41.6% were having type II respiratory failure (p=0.01), had longer hospital stays (p=<0.0001) when compared to group II which were statistically signicant. So electrolytes should be routinely tested to prevent worse outcomes.
MRI EVALUATION OF WRIST JOINT PATHOLOGIES IN PATIENTS PRESENTING WITH CHRONIC PAINFUL WRIST.
Authors: Shingne Akash , Pawar Anjali , Rote Varsha
Published: May 2023

Background: MRI is an efcient approach for assisting in the diagnosis of chronic wrist pain. Due to its high resolution, multiplanar imaging
capabilities & no use of ionizing radiation, MRI is useful for evaluating different ligaments, tendons, carpal tunnel, articular cartilage, and bone
marrow in wrist joint. MRI is useful in the identication, characterization, and staging of osseous damage and illness. This is Material & methods:
cross sectional descriptive study performed in tertiary care hospital during year 2021-22. In this study, 50 patients presenting with chronic wrist
pain without trauma underwent MRI wrist. Wrist joint & its pathologies in these patients were evaluated on 3T MRI scanner. In this study Results:
20% cases were diagnosed with tendinitis followed by 18% cases were diagnosed with Tenosynovitis, 16% cases with Ganglion cyst, 10% cases
with carpal tunnel syndrome, 8% cases with degenerative TFCC tear, 6% cases with RA, 4% each cases with GCT, Gout, Osteoid osteoma and TB
arthritis respectively and 2% each cases were diagnosed with infective arthritis, Kienbock's disease and simple osseous cyst respectively.
Conclusion: 1) MRI wrist joint with 3D imaging is a radiation free imaging technique which is very useful in diagnosing different pathologies of
wrist joint. 2) MRI is important modality to diagnose precisely the various non traumatic pathologies of wrist joint causing chronic pain. 3) It is a
radiation free technique which is very helpful for the conclusive diagnosis & further treatment of the patient.
COMPARISON OF GRACE (GLOBAL REGISTRY OF ACUTE CORONARY EVENTS) SCORE AND SERUM NT- pro BNP LEVEL IN PREDICTING 30 DAY MORTALITY IN PATIENTS WITH NON- ST- SEGMENT ELEVATION ACUTE CORONARY SYNDROME (NSTE-ACS) ATTENDING EMERGENCY DEPARTMENT.
Authors: U Deka , R.P Das , D. K Sarma
Published: May 2023

Coronary Artery Disease (CAD) is the single most frequent cause of death worldwide. More than seven million people die from CAD every year,
accounting for 12.8% of all deaths. Acute coronary syndrome (ACS) is a potentially life-threatening manifestation of CAD where time is crucial in
initial management. Patients with ACS are divided into two groups to facilitate evaluation and management namely acute myocardial infarction
(MI) with ST segment elevation (STEMI) on their presenting electrocardiogram(ECG) and those with non ST segment elevation acute coronary
syndrome (NSTE-ACS) or non ST segment elevation myocardial infarct ion (NSTEMI).The incidence of NSTEMI is rising due to the increasing
burden of obesity , chronic kidney disease and increasing detection of myocardial necrosis by raised hsTrop I (high sensitive Troponin I). We
aimed to explore the utility of biomarker like serum NT-pro BNP level with the Global Registry of Acute Coronary Events (GRACE) risk
calculationin patients presenting with non-ST-elevation acute coronary syndromes (NSTE-ACS) .A total no 33 patients were included in this
study. From the comparison of GRACE SCORE and serum NT-proBNP, the difference in 30 day mortality in patients with NSTE-ACS it had been
observed that based on optimal cut off from ROC curve ,the area under the curve(AUC) for GRACE score and serum NT-proBNPwere 99 vs 89.7
with a sensitivity and specicity of 98% vs 92.86%, 94.74% vs 73.68% respectively.
STUDY OF HISTOMORPHOLOGICAL SPECTRUM OF RENAL TUMORS- A RETROSPECTIVE STUDY
Authors: Khataniar Limpy , Sonowal Sima , Dutta Aparna
Published: May 2023

Background: The kidneys remove waste product from the body, maintain blood pressure and regulate electrolyte balance. Renal tumors show a wide spectrum which is distinct in adults and children. To study the histom Aim: Materials and Methods: orphological spectrum of renal tumors. It was a retrospective study of renal tumors in a tertiary care centre of Department of Pathology, AMCH from the from January 2018 to January 2022. A total 10 cases of renal tumors were seen. Out of total of 10 cases (M Result: : F-four: six, age range: 1 to 70 yrs.) clear cell renal cell carcinoma was seen in 6/10 cases (60%), 1 (10%) papillary renal cell carcinoma, 1 case of chromophobe (10%) and 2 nephroblastoma (20%). Thus, this study showed that renal tumors occurs both in children and adults. There was preponderance of female cases.
SURVIVALANALYSIS OF CARCINOMA CERVIX IN REGIONAL CANCER CENTRE: BANGALORE
Authors: C R Vijay , K Shobha , D Ashalatha , Sridhar P , Lokesh V
Published: May 2023

IntroductionAtotal of 19.3 million cancer incidences were estimated globally for the year 2020. The Cancer Cervix showed the predominant site
and 2nd leading site in Population-Based Cancer Registries after Carcinoma of Breast. This retrospective study is conducted at Kidwai Memorial
Institute of Oncology and the data were collected from 2006-2007 and followed up for a 5-year period. The loss for follow-up is the main obstacle to
carrying out Survival analysis. Material and Methodology The le abstraction method was followed to collect the retrospective data. This Study
comprised of histopathologically proven cases, treated only at the Research Institute residing in Bengaluru, who were diagnosed between 2006 and
2007. 2471 cases of cervical cancer were diagnosed, out of which 287 were considered for the study. The registered cases were followed up for 10
years. Kaplan-Meier survival analysis and Loss-adjusted survival analysis are used to evaluate. Results Stage I: 9.1% of follow-up cases were
compared to 3.4% of dropouts. 31.4% of follow-up cases were compared to 20.7 dropouts in stage II 59.6% and 75.9%, respectively, in stage III.
The percentage of survival using Loss-adjusted survival methods was found to be 82.8%, 80.8%, and 71.7% for the age groups 1, 2, and 3
respectively. There is no signicant difference in the survival proportion between Kaplan Meier and loss-adjusted methods observed with respect
to age group. The ve-year survival rate of Stage-I, Stage-II and Stage-III was found to be 85.9, 82.6, and 74.2 respectively, and the difference
between survival in each stage group was signicant (p 0.032) in the Kaplan-Meier method. The Loss-adjusted survival analysis method also
estimated a nearly identical percentage of survival except in stage III. The percentage of difference was found to be 0.50 to 2.77 for stages I and III
respectively, the difference was not signicant at the 5% level of signicance. Conclusion: Late diagnosis of cervical cancer appears to be mainly
associated with a higher risk of dying from cervical cancer. Loss adjusted survival analysis has more impact when censored data (lost for follow up)
is greater than 20–30%. In the above case, the Kaplan-Meier method overestimated the survival rates compared to Loss loss-adjusted survival
method. When there are more variations in the distributions of the censored data, in that case, there is a statistical difference between the Lossadjusted and the Kaplan-Meier method. In this situation, Kaplan-Meier method is underestimating the survival of the patients. Kaplan- Meier
survival analysis does not yield a consistent result while increasing dropouts; hence, the Loss-adjusted survival method gives better estimates
A NOVEL OSSEOUS DENSIFICATION APPROACH IN IMPLANT OSTEOTOMY PREPARATION TO INCREASE BIOMECHANICAL PRIMARY STABILITY
Authors: Ramya R Shree , Kumari Poovani Shwetha , Sreeji Shajith
Published: May 2023

Prosthetic rehabilitation of missing teeth (partial/complete) using dental implant has been an established procedure for a long time. Conventionally
it involves the use of twisted drills to prepare the implant site. However, the use of modied drills such as Densah burs is relatively new. It works in
densifying mode by compacting the bone into a prepared osteotomy site which leads to an increase in primary stability due to an increase in boneimplant contact. This method is based on the principle of bone conservation and it can be used as an essential treatment alternative. The case report
presented here describes the utilization of the novel technique for the implant site preparation when there is alveolar ridge deciency and the
successful osseointegration of dental implant without the need for any additional surgical procedure to carry out any bone augmentation. The
results of this study concluded that, adequate implant stability with preservation of alveolar ridge integrity was achieved, resulting in a shorter
duration of restoration for the patient.
ROLE OF MRI IN EVALUATION OF PRIMARY BONE TUMORS
Authors: Chandra Adurti Ramesh , Goud G Ramesh
Published: May 2023

Magnetic Resonance Imaging (MRI) is maximally sensitive to the presence of musculoskeletal soft-tissue lesions and also provides exquisite denition of their features. The purpose of this study is to evaluate the role of MRI in cases of bone tumors, to determine the MRI characteristics of different primary bone tumors and to evaluate the role of magnetic resonance imaging in prediction of malignancy and delineation of anatomic extent of primary bone tumors.
The prevalence of IGM antibodies to Zika virus in pregnant women in Northern Nigeria
Authors: Adekola Hafeez Aderinsayo , Ojo David Ajiboye , Balogun Saka Adebayo , Dipeolu Morenike Aderonke , Mohammed Musa , Adejo Daniel Stephen , Aliyu Rabi'at Muhammad , Abdullahi Mohammed Asara , Madugu Nana Hawwa
Published: May 2023

Introduction. Zika virus (ZIKV) infection during pregnancy can result in severe outcomes for both the pregnant woman and the developing fetus.
The objective of this study was to investigate the prevalence of Zika virus infection among pregnant women who sought healthcare services at Ahmadu Bello University Teaching Hospital.
Materials and methods. Serum samples were collected and analyzed using Enzyme Linked Immunoassay and RT-qPCR methods, while a structured questionnaire was used to gather relevant information about the participants.
Results. The results showed that 53 out of the 180 pregnant women tested positive for Anti-Zika IgM antibodies, which represents a 29.4% prevalence rate. Subsequent RT-qPCR analysis found that only 6 out of the 53 positive samples contained Zika virus RNA. Fever and headache were the most commonly reported symptoms related to the infection.
Conclusion. These findings indicate a potential outbreak of Zika fever in Northern Nigeria emphasizing the importance for pregnant women to take precautions to avoid getting infected.
Circulation of bovine herpesvirus (Herpesviridae: Varicellovirus) and bovine viral diarrhea virus (Flaviviridae: Pestivirus) among wild artiodactyls of the Moscow region
Authors: Pchelnikov Alexander V. , Yatsenyuk Svetlana P. , Krasnikova Maria S.
Published: May 2023

Introduction. Pestiviruses and viruses of the Herpesviridae family are widely distributed among different species of ungulates, but the main information about these pathogens is related to their effect on farm animals. Data on detection of bovine viral diarrhea virus (BVDV) and bovine herpes virus (BoHV) in wild ungulates reported from different countries in recent years raises the question of the role of wild animals in the epidemiology of cattle diseases. Aim of work. To study the prevalence of herpesviruses and pestiviruses in the population of wild artiodactyls of the Moscow region. Materials and methods. Samples of parenchymal organs and mucosal swabs from 124 wild deer (moose and roe deer) shot during hunting seasons 20192022 in Moscow Region were examined by PCR, virological and serological methods for the presence of genetic material and antibodies to bovine infectious rhinotracheitis and viral diarrhea. Results. BVDV RNA was found in a sample from one moose, BoHV DNA was detected in samples from three roe deer and two moose shot in the Moscow region. Seropositive animals were of different sex and age, the total BoHVs and BVDV seroprevalence rates in wild artiodactyls were 46 and 29%, respectively. Conclusion. Wild ruminant artiodactyls of the Moscow Region can be a natural reservoir of BoHV-1, and this must be taken into account when planning and organizing measures to control the infectious bovine rhinotracheitis. Cases of BVDV infection in wild artiodactyls are less common, so more research is needed to definitively establish their role in the epidemiology of this disease in cattle.
Virus-like particles based on rotavarus A recombinant VP2/VP6 proteins for assessment the antibody immune response by ELISA
Authors: Filatov Ilya E. , Tsibezov Valery V. , Balandina Marina V. , Norkina Svetlana N. , Latyshev Oleg E. , Eliseeva Olesia V. , Cherepushkin Stanislav A. , Verkhovsky Oleg A. , Grebennikova Tatyana V.
Published: May 2023

Introduction. Rotavirus infection is one of the main concerns in infectious pathology in humans, mammals and birds. Newborn piglets or rodents are usually being used as a laboratory model for the evaluation of immunogenicity and efficacy for all types of vaccines against rotavirus A (RVA), and the use of ELISA for the detection of virus-specific antibodies of specific isotype is an essential step of this evaluation.
Objective. Development of indirect solid-phase ELISA with VP2/VP6 rotavirus VLP as an antigen to detect and assess the distribution of RVA-specific IgG, IgM and IgA in the immune response to rotavirus A.
Materials and methods. VP2/VP6 rotavirus VLP production and purification, electron microscopy, PAGE, immunoblotting, ELISA, virus neutralization assay.
Results. The study presents the results of development of a recombinant baculovirus with RVA genes VP2-eGFP/VP6, assessment of its infectious activity and using it for VLP production. The morphology of the VP2/VP6 rotavirus VLPs was assessed, the structural composition was determined, and the high antigenic activity of the VLP was established. VLP-based ELISA assay was developed and here we report results for RVA-specific antibody detection in sera of different animals.
Conclusion. The developed ELISA based on VP2/VP6 rotavirus VLP as a universal antigen makes it possible to detect separately IgG, IgM and IgA antibodies to rotavirus A, outlining its scientific and practical importance for the evaluation of immunogenicity and efficacy of traditional vaccines against rotavirus A and those under development.
La preservación de la tesis de la localidad para los casos de doble prevención en la crítica de Ned Hall al análisis contrafactual
Authors: Melogno Pablo
Published: May 2023

Este trabajo discute una de las objeciones de N. Hall al análisis contrafactual de D. Lewis. Según Hall, los intentos de fortalecer el análisis contrafactual se apoyan en la aceptación de la transitividad, la localidad y el carácter intrínseco de las relaciones causales. Esto es problemático en cuanto el concepto de doble prevención evidencia tensiones entre estas tres tesis y el concepto de dependencia, central en el análisis de Lewis.
Revisando uno de los ejemplos de Hall, se defiende que su crítica al análisis contrafactual cumple parcialmente su objetivo en referencia a la localidad, ya que sólo una de las estructuras causales que Hall presenta acepta la dependencia y no la localidad, no tratándose de un típico caso de doble prevención. Finalmente se propone la denominación early doble prevention para los casos que aceptan la dependencia y no la localidad, y late doble prevention para los que aceptan ambas tesis.
Anti-staphylococcal activity and cytocompatibility of lysostaphin
Authors: Gordina E.M. , Bozhkova S.A. , Labutin D.V. , Goncharuk D.A. , Tkach E.N.
Published: May 2023

Objective.
To study the antibacterial activity of lysostaphin against staphylococci various species, as well as its effect on the viability of Vero cells.

Materials and Methods.
Lysostaphin was obtained by genetic engineering. Purification of the protein was carried out on SP-sepharose, the purity was determined by electrophoresis in PAGE by Lamley. The susceptibility to lysostaphin of 9 species 175 strains of staphylococci was studied. Identification was performed by MALDI-TOF MS, antibiotic susceptibility by EUCAST (v. 11.0). The MIC of lysostaphin was studied by the method of serial dilutions with concentrations between 0.015 and 512 mg/l. For 72 hours, the viability of Vero cells with lysostaphin at concentrations of 0.5-32.0 mg/l was determined by the MTT method with counting of living cells according to their growth curve. The results were analyzed by ANOVA followed by Dunnett’s test.

Results.
A kinetic study of S. aureus growth in the presence of revealed an inhibitory effect of endopeptidase (MIC 0.06 mg/l). Lysostaphin was characterized by pronounced activity against clinical methicillinsensitive S. aureus. The MIC ranged between 0.03 and 0.5 mg/l and the MIC50/90 was 0.125⁄0.5 mg/l. For methicillin-resistant S. aureus MIC50/90 0.25⁄0.5 mg/l. The MIC50 for MRSE was 2 times higher than for MSSE – 1 mg/l. The maximum MIC value was determined against isolates of S. warneri and S. hominis – 64 mg/l, the lowest for S. saprophyticus – 0.5 mg/l. MIC50 of lysostaphin against MRSA was 4 times lower than that of vancomycin, MIC90 was 3 times lower. Differences in viable cells depending on the concentration of lysostaphin were not found.

Conclusions.
Significant activity of lysostaphin against staphylococci was revealed, which is several times higher than vancomycin against MRSA. Lysostaphin was also effective against methicillin-resistant S. aureus. The high anti-staphylococcal activity and cytocompatibility of lysostaphin are promising for its further study in the prevention and treatment of staphylococcal orthopedic infections.
Iron Intake and Iron Inhibitor and Enhancer Intake with the Incidence of Anemia Among Adolescent Girls
Authors: Fauziyah A'immatul , Putri Haniyyah Prastia
Published: May 2023

Anemia, especially iron deficiency anemia was marked with low hemoglobin (Hb) concentration than normal standard.Adolescents, especially girls when reached the age of menstruation were prone to this type of anemia because of blood loss from their monthly cycle. This research objective was to analyze the participant’s intake of iron, iron enhancers, and inhibitors intake and analyze its relationship to anemia incidence of MTs. Fadlurrahman, Bekasi 2022. This cross-sectional research used stratified random sampling based on their level of class. The participant’s number were 49 adolescent girls who met the inclusion and exclusion criteria. 36,70% of all subjects had anemia. Most subjects (75,51%) had low iron consumption, rare iron enhancers consumption (75,51%), and frequent inhibitors consumption (51,02%). All the independent variables (iron intake, iron enhancers consumption, and iron inhibitor consumption) had a significant relationship (p<0,05) to the dependent variable (anemia incidence). This finding implicated adolescent girls in MTs. Fadlurrahman needs to consume more iron-rich foods and their enhancers while lower its inhibitor intake.
Developmental Integration and Industrialisation in Southern Africa
Authors: Duma Siphumelele
Published: May 2023

Since the beginning of decolonisation in Africa, regional integration has become one of the most potent defining characteristics of the continent’s quest for industrialisation and sustainable development. It was understood that the individual continental economies could not achieve the requisite level of industrial development to meet their respective development objectives due to the colonial policy of balkanisation, which divided the continent into small, economically unviable units. In 1992, the Southern African Development Community (SADC) adopted developmental integration, an approach to regional integration to engender industrialisation and address the region’s development challenges. This book offers a critical assessment and examination of this approach as to how it has influenced the industrialisation process in Southern Africa. If so, why has it failed to accelerate the region’s industrialisation and structural transformation process? It contributes significantly to cross-cutting development debates on the African continent, particularly in southern Africa. More importantly, in understanding the nexus between developmental integration and industrialisation.
Identification of the states of the synchronization system based on its entropy analysis
Authors:   Emperor Alexander I St. Petersburg State Transport University, Kanaev Andrej K. , Oparin Evgenij V. ,   CJSC "Institute of telecommunications", Oparina Ekaterina V. ,   Emperor Alexander I St. Petersburg State Transport University
Published: May 2023

To provide reasonable identification of the states of the process of functioning of the synchronization system in communication networks for making rational and operational decisions on its management and technical operation. It is proposed to achieve this goal by forming an entropy model of the dynamics of the synchronization system based on the analysis of the values of its diagnostic parameters. To identify the state of the process of functioning of the synchronization system, it is proposed to use differential entropy as a system-wide parameter for evaluating systems. The calculation of the differential entropy of the synchronization system is based on the values of the differential entropy of its elements, which are estimated based on the assessment of diagnostic parameters. Further identification of states is carried out by using pattern recognition algorithms. Methods: research methods are used in the work, which are based on the principles of the theory of networks and systems, system and mathematical analysis, entropy and mathematical modeling. Results: as a result of the research, an entropy model of the dynamics of the synchronization system was obtained, an approach was proposed for assessing the state of the synchronization system by analyzing its differential entropy as a system-wide parameter. The theoretical significance of the work lies in the expansion of the methodological base for the construction of control systems for the synchronization of communication networks. The practical significance of the work lies in the use of the obtained results for the design and modernization of synchronization control systems in the field of forming reasonable management decisions.
Statistical characteristics of the signal at the output of the optimal radar system for identifying mobile air objects
Authors:   Moscow technical university university of communications and informatics, Ukhanov Evgenii V.
Published: May 2023

This work can be considered as a continuation of the article, or as separate materials devoted to the recognition of moving air objects based on the theory of testing statistical hypotheses. In the future, when presenting the materials of this article, the terminology proposed in [1] will be used. The relevance of this article is due to the events taking place on the European continent, indicating the need for further development of radar systems for various purposes and the transition from radar to radio vision, which will significantly improve the effectiveness of air defense and airspace control in general. The construction of a radar portrait and further automatic recognition of moving air objects, as an element of artificial intelligence, will eliminate human error, as well as significantly reduce the time it takes to make a decision on the necessary measures to influence the detected aircraft. Studying the freely available scientific works of various scientists devoted to such a direction of research and development of artificial intelligence as the statistical theory of pattern recognition, one can note the absence of such an important element as the function of the dependence of the probability of correct recognition on the quality and noise of the image. Within the framework of this article, a variant of solving this problem in the form of a mathematical model will be proposed. Since in [1] a recognition method is considered that uses the correlation coefficient between the current image and the reference one, and the probability of correct recognition is estimated using the Neumann-Pearson criterion, it is proposed to plot the dependence of the probability of correct recognition on the ratio of the image energy EI to the spectral noise density (R = 2EI/N0R), for a given false recognition probability . In the future, in the presented work, this dependence will be called recognition characteristics. Graphs will also be considered, in this paper referred to as the distribution density of the recognition probability.
Models and methods for calculating delays in the provision of services by the user on the service platforms of session infocommunication services
Authors:   The Bonch-Bruevich Saint-Petersburg State University of Telecommunications, Redrugina Natalia M.
Published: May 2023

The purpose of this article is to develop methods for calculating the qualitative characteristics of infocommunication services whose workloads consist of user sessions. The scope of application of these methods affects the development and maintenance of infocommunication multi-user services, in terms of ensuring a high quality of user service. The quality of service (QoS) parameters under consideration determine the characteristics of both the system as a whole and individual elements of its architecture, and for this type of service, the qualitative characteristics are the waiting time for the start of user session maintenance, the load factor of server equipment, the number of user sessions simultaneously supported by the system during its error-free operation. Multi-user services are considered from the point of view of queuing theory as a network of queuing systems, with the duration of the user session and the time of receipt of requests for services by gaming services distributed exponentially. To evaluate the parameters of the models of infocommunication multi-user services, Jackson networks were chosen as a mathematical apparatus, which allow us to consider the necessary systems of the type M/M/v. As an approbation of the results, a mathematical analysis of multi-user gaming services was proposed, since their popularity, and hence the flow of users to game servers, is increasing at a tremendous rate. As an additional tool for assessing the qualitative characteristics of the session models under consideration, simulation modeling was proposed, which allows us to evaluate the accuracy of the proposed analytical method and analyze the characteristics of complex systems with time distribution laws other than exponential, for example, long-tailed distributions (Weibull, Pareto, etc.)
Practice and consideration of master protocol in clinical trials
Authors: Song Jiali , Rong Zhiwei , Zhong Xinwen , Lu Yuhong , Huang Jike , Yu Yipei , Liu Zhilin , Quan Xuyuan , Chen Nana , Li Kang , Sun Fengyu , Hou Yan
Published: May 2023

There is considerable interest in expediting late-stage therapy development by efficiently conducting trial designs that encompass multiple therapies or multiple subpopulations simultaneously within a unified protocol. Such trial designs are referred to as master protocols, with specific designs characterized by the terms umbrella, basket, or platform. These designs, in contrast to the traditional trial designs, are full of complexity. What factors should be considered in designing a trial ensuring the safety of human subjects and demonstrating the efficacy of new therapy? This paper overviews the master protocol framework, comprehensively unifies the definitions, and illustrates essential design elements of representative example trials conducted in drugs and medical devices. Besides, to understand the master protocols deeply, it is also a need to summarize the commonly-used types of master protocols in various disease and treatment fields, along with the reasons for these phenomena by analyzing the characteristics of the diseases, the mechanism of therapeutic products, and the principles of various types of master protocols. Finally, we also propose practical considerations, including the design, ethical, statistics, and funding considerations that arise from implementing complex master protocols. This information serves to guide practitioners in designing more effective trials and identifying potentially valuable therapies.
Effect of E-content in Enhancing the Learning of Tamil at Higher Secondary Level
Authors: - S.P.Paramasivam , - K.Nachimuthu
Published: May 2023

This paper entitled 'Effect of E-Content in Enhancing the Learning of Tamil at Higher Secondary Level' is tried to test the effect of the e-content package in studying Tamil Prose at the XI standard position by picking a sample of 60 students containing 30 each with control and experimental group by espousing pre-test and post-test control group design. It attains that, there is a significant difference between the experimental group and the control group students. Hence, it's approved to modernize the studying strategy at the XI standard in learning Tamil Prose and it concluded to support the experimental group results on the effect of e-content in Tamil Prose is a positive one.
‘‘Two Tiers or Three Tier’ a Never-ending Saga of Dispute Settlement– A Delaying Mechanism Arbitration
Authors: - S. Bhavya Shree , - Ramanya Gayathri M
Published: May 2023

Two Tier Arbitration or Appellate Arbitration is recognised by Court through its various judicial pronouncements. Even though Party Autonomy and fair mechanism are the stand points by which court gives importance or validity to Two Tier mechanism, it has unnecessarily opened the gates for delayed mechanism. The famous Centro trade Minerals and Metal Inc. v. Hindustan Copper Ltd. decision has further strengthened the principle that there is less chance of court intervention. All these shows the positive impact the particular mechanism will bring but the main question here is: Whether Arbitration mechanism is going far beyond speedy redressal of disputes? Or Whether the processes right now the Court’s rely on party autonomy is relatable to unnecessary court proceedings which we are tired off.
In this Article the author’s try to analyse the repercussions that will create if Court starts supporting various appellate, revisions or review mechanisms in Arbitration proceedings. The Author’s surmises the Article by providing suggestions on appropriate implementation of Arbitration regime in India by comparing with other countries.
The Impact of Module Enhancement in the Remote Area Amidst the Pandemic Covid 19: A Community Extension Program
Authors: - Aurizia Duhah Siraji
Published: May 2023

The use of suitable and relevant pedagogy for online education may depend on the expertise and exposure to information and communications technology (ICT) for both educators and the learners. Some of the online platforms used so far include unified communication and collaboration platforms such as Microsoft Teams, Google Classroom, Canvas and Blackboard, which allow the teachers to create educational courses, training and skill development programmes (Petrie, 2020). This study is an assessment of the aforesaid program. Module Enhancement in the remote area was aimed to educate and capacitate the beneficiaries with practical skills, techniques, or ideas which they can then use in their blended learning. The study determined the effect of the program on the beneficiaries’ personal and professional development acquired from the training. Mixed- method was used in the study. Surveys and focus group discussion (FGD) was used to gather data. The study found that the beneficiaries acquired the different teaching modalities learned from the training. Ninety percent 90% beneficiaries used the skills they learned from the program. 85% beneficiaries respond that the program has helped them in introducing Modular learning. Generally, the learning acquired by the beneficiaries of Sulu State College extension program was found to be useful at Maimbung National High School, one of the remote areas in the province of Sulu.