bluuebunny/crossref_metadata_2025 huggingface dataset:
FROM THE OLD ONE TOWARDS THE NEW WITH VLADAN DJORDJEVIC, M. D.
Authors: Čukić G.
Published: November 2024

Every time, even ours, has its own «driving forces, starters and breakers». Dr Vladan Djordjevic resided during the very noisy time during the second half of the nineteenth century, known for intensive changes in biology and medicine. Contemporaries noticed peculiar nature of Dr Vladan Djordjevic: clairvoyant, cleverness - «gave more, than many other simple professionals together». If even nowadays the way of how a man thinks is not known, that is logical structuralism and logical functionality of thinking, scholastic is wrong that such a «natural thinking», certainly, enters into cliché. The author applied nine-valence logic and systematic approach. The measures in eradication of diseases which, used to be applied nowadays would be called "general hygienic measures". They didn't have to be sufficiently effective, so the possibility of appearance for some sick stayed, because it would appear in natural system of appendage, few «causative connection», but noticeable less that earlier. The helth ones exposed can be used for prooving cause, which contemporary statistic doesn't use for this purpose. By this, even when we have not existing of statistic importance it points out at the cause; that is, the existence of this one can direct someone to wrong road. The difference in the value of the result of the same event points out at the researches not being orientated and by that cosmopolitan community. Palliative measures made the doctors confused, as it was perfectly noticed by V. Djordjevic - "...he wouldn't make a mistake to prove, how people get sick and die because they are better dressed, better feed, because all their life is better organised than it used to be", although the group progressed by its better working. Multy valence »logic of allowance” as a natural and objective one, used to exist before its observation by logic and science. The result is «clairvoyant and restless spirit» of the future academic Vladan Djordjevic D. M. what is even nowadays desirable. The author concludes that there is one road to discover something (anticipate) by adding importance to «statistic importance»; and the other one, chosen by Dr Vladan Djordjevic by your own ratio (intuition). Although the disease appeared even when the progress is made - he didn't allow: «not to see the whole forest because of one wood», and to underestimate the applied measures. He didn't allow to be deceived by appearing of disease, because the palliative of measurements covers the system: а. When you are not successful, but and b. Even when you are successful - and those have to be separated by contemplation and by no means unifies!
THE INFLUENCE OF ENVIROMENT AND EDUCATION ON INFORMATION ABOUT HORMONAL SUPSTITUTIONAL THERAPY (HST) IN MENOPAUSE
Authors: Stajić D. , Bujas M. , Stević S.
Published: November 2024

Menopause is a physiological condition arising from the end of a woman's reproductive life and is defined by the gradual decline of menstrual bleeding over a period of 12 months. Hormone Replacement Therapy (HRT) is the first choise therapy in treating this condition, and prevention of early and late problems associated with hormone deficient in menopause. This study was organized on Clinics for Gynecology and obstretics in Novi sad. We were examined women knowledge about HRT, as the number of active users of HRT. Two hundred testing women were divided into two groups, arrived from city or willage regions, and they had different education level. Our results showed that number of examined persons, who were infomed about HRT, was significantly higher in city region, but number of HRT users was nearly the same for both groups. Education degree is the significant factor associated with information about HRT. High education women were better informed according to women with lower education. Irrecpective of origin and educational degree, there was statisticaly little number of women, who use HRT, despite of their aknowlegment about this way of therapy. According to our results, we conclude that, it is very important to conduct a proffesional aproach, including continual preventive action, for resolving hesitation to HRT
CORRELATION BETWEEN SOFT PALATE LENGTH AND CHRONIC MIDDLE EAR INFLAMMATION
Authors: Erdevički Lj. , Stojanović J. , Belić B.
Published: November 2024

The role of Eustachian tube dysfunction in chronic middle ear inflammation etiopathogenesis is obvious and almost always present. Shorter length of m. tensor velli palatini, the only active opener of the Eustachian tube, is related to tube dysfunction. The aim of the study is to investigate correlation between soft palate length, angle formed between soft and hard palate and chronic middle ear inflammation occurrence. Examinations have been performed on 60 adults. Group A consisted of patients suffering from chronic middle ear inflammation, whereas group B consisted of healthy individuals with respect to their gender and age. Examinations included medical check-up, auditory findings, radiological examinations and craniometrical X- ray measurements performed using lateral head X-ray. Soft palate length and angle formed between soft and hard palate angle were measured. It has been determined that soft palate length (distance from spine nasalis to the top of the uvula) is shorter in patients suffering from chronic middle ear inflammation ( average value for group A= 3,09, SD=0,422, whereas for group B =3,747, SD=0,448). Student test results indicate highly significant difference between examined groups ( value of variable t=6,025). Angle formed between hard and soft palate is higher in group A examinees (average value 138.4, SD=9.379, than in control group (average value 132,17, SD=8.765). Value of the variable t=2,658 indicate the significant differences in values between examined groups. Soft palate in patients suffering from chronic middle ear inflammation is positioned more horizontally and its length is shorter than in control group B. Depth and volume of the nasopharynx is lesser in group A patients. These soft palate dimensions impact soft palate muscular disbalance, mostly m. tensor velli palatini. In dysfunctional tube, medial lamina cartilage rotation is insufficient and muscular movement is minimal. Defining soft palate dimensions and nasopharyngeal morphology Eustachian tube dysfunction can be explained and chronic middle ear inflammation development predicted
POSSIBILITY TREATMENT FRACTURES TROCHANTERIC AREA, INTERNAL FIXATOR WITH DOUBLE DYNAMISATION BY MITKOVIC
Authors: Petrović D. , Vasić A. , Dimić S. , Božović A.
Published: November 2024

Transtrochanteric fractures represente ekstracapsular fracture proksimal heel of femur, but sometimes is possible to stretch fracture line in intracapsular area. All this fracture represente large disability for patient, large life threatening and if is don`t have adequate treatment substantially is change quality of life. Most of patient with transtrochanteric fractures is older than 65. years with prevalence women gender in attitude 3:1. Number of patient with fracture proksimal heel of femur and with fracture trochanteric area growing up from year to year. In west country this fracture get epidemic shape. For make work it is used material from department of Orthopaedics and traumatology in Medical centre in Kosovska Mitrovica in interval at 2003. to 2006. years. In process of work we follow frequency patient with transtrochanteric fractures in attitude at gender, age, way of injury. We following time elapsed from fractures to surgery treatment, kind of anesthesia, number of day after operation. In postoperative course following is time verticalization patient, presence early and late complication. The ultimatefunctional results which we receive, were shown according to the modificated scale by Merle d'Aubigneu
HEALTH STATE EVALUATION OF POPULATIONHISTORICAL LOOKING BACK AND MODERN APPROACH
Authors: Mirković M. , Parlić M. , Trajković G. , Ćorac A. , Vukotić M. , Đurić S.
Published: November 2024

Search for objective indicators of health state of the population is essential public health issue. First serious attempt of health evaluation of the population were observed in the end of 18. and beginning of the 19. century. In this period of time, description of health population was mostly based on indicators which were based on data of numbers of death. Later, because of significant decrease of infectious disease and improvement of life and work conditions comes to an extension of average life span. Also, comes to a change of conceptualization of health. As a result of all this changes it has been noticed need for consideration of other aspects of health. As a outcome, indicators of disease, disability and non-biological indicators of health (as a approach to health service, quality of health protection, condition of living, life style factors and environment factors) are more and more necessary for documentation of human capacity for physical, mental and social functioning as a objective analysis of health state. To get all the information of all aspects of health which can not be get from health statistics routine data, was started with examination of population health trough interview, respectively polling out representative population sample. Aim of this studies is to get basic information about population health, in manner to supplement the picture of population states, identify health problems and health needs, to get the picture of representations of risk factors among population; to get the picture of health service utility; to find out health disparity among different countries and inside the country, among different population groups; to follow the change of health states during the time; to follow achievement in health strategy; to insure data for people which are creating health politics, in manner to coordinate theirs politics, strategy and programs. This kind of study is taking place every year in many countries and in others periodically. In our country this kind of studies were done during the year of 2000. and 2006
МОRPHOLOGICAL AND MORPHOMETRIC ANALYSIS OF ACCUMULATION THE LIPOFUSCIN PIGMENTIN GANGLIACELLS IN THE CERVICAL PARTOFSYMPATHETIC TRUNK IN THE PROCESS OFOLD AGE
Authors: Filipović T. , Stefanović N. , Vitošević Z. , Milisavljević M. , Đukić N. , Mandić P. , Matejić S. , Šaranović M.
Published: November 2024

Old age can be defined as a variety of changes in structure and function which begin at the stage of reproductive maturity, and that changes are manifested as a lesser ability of adaptation and lesser way of defending from the influence of outside and inside factors. Neurons of sympathetic trunk, as well as the other neuron cells, are changeable during the life. Neurobiological, old age begins at the time of birth, because the number of neurons is not increasing, it's only getting lower, which means that neurons are post mitotic cells. The process of old age is increased with some degenerative changes at some diseases and its hard to know what belongs to, so called, physiologic way of getting old and what is pathologic. Concentration of lipofuscin in cells (pigment of old age), is the parameter for physiologic old age of a person. Concentration is changeable, and it depends from the tissue or the organ, concentration is controlled by the internal regulatory factors and the factors of environment as the way of nutrition, physical activity, stress and hygienic factors.
FACTORS MORBIDITY AND MORTALITY OF MOTHERS MULTYPAROUS IN PERINATOLOGY
Authors: Andrejević A. , Cvetkoviċ S. , Dunjić M. , Relić G. , Čanković P.
Published: November 2024

The aim of work was to find out whether multiparity led to increased morbidity and mortality of mothers multyparous. Special attention was paid to appearance of diseases among mothers, both those developed during pregnancy and immediately after delivery. Multiparity is especially characteristic of women of Albanian nationality. Thus it is obvious that there is a reverse proportion between multiparous women and level of education the higher level of education is the smaller is the number of previous deliveries. There is a significant difference in apsolute number of deliveries according to the place of living in favor of rural residence. Number of both EPH gestoses (Eclampsia, pre-eclampsia) and indications for Caesarian section is increasing with multiparity. Abruption of normaly inserted placenta is significantly more frequent among multiparous women. It is obvious that multiparous women more frequently have bleedings during third and forth delivery period. There were also a large number of hysterectomies during delivery (75). Death rate of women is significantly increasing with multiparity. Eclampsia is the cause of death among more than half of all women. Resuming all data the autor is pointing out that grand multiparity, giving birth to more than six children, is, mfom medical point of view, an increased risk both for a newborn and a pregnant woman. Perinatal motality and morbidity is increased and high risk during pregnancy, delivery and puerperium is simultaneously rising until the pregnant woman's life is seriously endangered
COMORBIDITY COMORBIDITY AND RHEUMA AND RHEUMATOID ARTHRITIS THRITIS
Authors: Tomašević-Todorović S. , Branković S.
Published: November 2024

Rheumatoid arthritis is a complex disease, which produces articular symptoms and damage, leading to disability. The aim of the study was the estimate frequency comorbidity, functional ability of patients with rheumatoid arthritis.This study included 60 patients (48 female and 12 male) with rheumatoid arthritis, mean age 53,92±7,06. Anatomical stage and functional class were analyzed according to Steinbrocker`s criteria. Functional disability was perfo-rmed using health assessment questionnaire (HAQ) score. Comorbidity was observed in 36 (60%) of patients (33 female and 3 male). Hypertension were found in 19 (31,67%) of patients, whereas 8 (13,33%) of patients had diabetes. It was established that 7(11,67%) of patients suffered osteoarthritis. The median HAQ score was 1,25±0,70. Poorer functional status was observed in 40% of the patients with comorbidity (HAQ score ≥2), than in the group of patients without comorbidity (21,67 %). The results of the study are showing large frequency coexisting disease in patients with rheumatoid arthritis. The frequency of hypertension and diabetes was greater comparing to general population. The patients with rheumatoid arthritis show harder anatomical stage and comorbidity and greater functional disability, as compared to the patients without coexisting disease.
L-CARNITINE IN CLINICAL APPLICATION
Authors: Vučinić B. , Mitić R. , Milanović Z. , Sovtić S.
Published: November 2024

L-carnitine is assorted with non-vitamin nutritives (metavitamines) on the grounds of importance to the living process, while itb similar to aminoacids in terms of structure. It has multistructural role in functioning of an organism while one of the most important and best investigated roles is the sphere of energizing metabolism because it is needed for the transport of the longchain fatty acids into the mitochondria where they are subject to a β oxidation. It has widespread clinical application in prevention and therapy of: genetic and secondarycarnithine deficiency, cardiovascular disease, lipid metabolism disorder, carbohydrate metabolism disorder, aciduria of organic acids, renal and liver insuficiency, neuropathy, miopathy, as well as the means for improvent of fitness capacites of sportsmen. L-carnitine is crucial part of organism of mamals, therefore it can be applied in relatively big doses whereby it requires no detoxication in liver, on the contrary, it significaty increases its detoxication capacites. Key words: L-carnitine, Physiology, Prevention , Therapy. L-carnitine is assorted with non-vitamin nutritives (metavitamines) on the grounds of importance to the living process, while itb similar to aminoacids in terms of structure. It has multistructural role in functioning of an organism while one of the most important and best investigated rol condarycarnithine deficiency, cardiovascular disease, lipid metabolism disorder, carbohydrate metabolism disorder, aciduria of organic acids, renal and liver insuficiency, neuropathy, miopathy, as well as the means for improvent of fitness capacites of sportsmen. L-carnitine is crucial part of organism of mamals, therefore it can be applied in relatively big doses whereby it requires no detoxication in liver, on the contrary, it significaty increases its detoxication capacites.
INTRAHOSPITAL MORTALITY OF PATIENTS SUFFERING AN ACUTE MYOCARDIAL INFARCTION AND THE IMPORTANCE OF MYOCARDIAL REINFARCTION IN THE INTRAHOSPITAL PERIOD
Authors: Marčetić Z. , Sovtić S. , Stašević Z. , Novaković T. , Đikić D. , Vasić S. , Antić G. , Rašić D. , Lazić S. , Šipić M. , Perić V.
Published: November 2024

Conclusion about efficacious of some medication can be given based on reducing morbidity and mortality in patients treated with that medication.. Aim of this work was to estimate intrahospital mortality in patients with acute myocardial infarction (AMI), role of myocardial reinfarction in that and side effects of medications in patients who were different treated in initial phase of AMI, based on what they were separated in three different therapeutic groups: group treated with thrombolytic therapy, group treated with beta-blockers and group treated with nitrates. It was shown that intrahospital mortality is highest in patients treated with nitrates but there was not significant difference between thera-peutic groups in frequency of myocardial reinfarction while frequency of complications and side effects were in range as in others similar studies.
THE IMPACT OF THE FACTORS AT RISK IN DEVELOPMENT OF THE ACUTE CEREBRAL STROKE, ATHEROSCLEROTIC INDEX FOLLOW UPAND IIGM
Authors: Čolić S. , Nenadović M. , Smilić Lj. , Marjanović J.
Published: November 2024

In the most prosperous countries, cerebrovascular diseases takes the high third leading position in mortality rate of the population, therefore justifying the name of a ,,mass killer,, speaking of which, its incidence represents un important not only medical but and socially economic problem (only 2-20% sick ones are able to continue with its previous work) Cerebral stroke incidence is 150-200 cases on 100000 persons per year (1). Taking in consideration all the mentioned, we took as the goal of the study, to investigate the impact of the factors at risk, in ethiopatogenesis of the cerebral stroke. Our study was carried out on 40 patients with acute cerebral stroke hospitalized on the Neurology Clinic, KBC Prishtina. Follow up of the factors at risk in atherosclerosis development included: cholesterol, HDLi LDLtriglycerides level in sera, blood and liquor glucoses, glucoses consuming index-IIGM. Descriptive values of the atherosclerosis index also, and the rate of the premorbid illness as the very important factors in development of the cerebral infarct.
PROGNOSTIC FACTORS IN THE BREAST CANCER
Authors: Dimić S. , Dimić I. , Petrović D. , Vučinić B. , Janković R. , Jakšiċ D. , Kovačević R. , Radosavljević Z. , Dančetović M. , Turković B. , Elek Z. , Milošević Lj. , Janićijević D. , Mitrović B.
Published: November 2024

Breast cancer is mostfreqency malignant tumor in womans, cardinal causer of death in malignant tumots with continous ascendig of incidence and mortality. Actual therapy of breast cancer is multidisclipinary to consist in surgical, irradiant, cytostatic, hormonal and imunological therapy with specific directive based in disease stage. Surgical therapy is now more effectiveness metod of therapy and base of multidisclipinary therapy. In aim of prognosis desease conclusion and risk ratio of local relapse in currency is prognostic factors. With combination a few factors derive prognostic indexes with whose can acquire more information aggainst biologic behaviour of each neoplasm.
TREATMENT LAESIO CORDIS LAESIO CORDIS WITH EMERGENCY WITH EMERGENCY CARDIORAPH CARDIORAPHY
Authors: Aranđelović S. , Sekulić S. , Mladenović J. , Pavlović A. , Odalović B. , Tabaković D. , Filipović M. , Ivanović D.
Published: November 2024

Autors reports 20 ten old boy received penetrating vulns thorasic with naif at midle linea.subksifoid area. Patient with angina pectoris, hypovolemic shock end cardiac arrest received at department intensive care Clinic hospital centre Prishtine in Gracanica. In cardiogenic arrest under reanimation is introduction in general endotracheal anestesy and intervention surgery. Maden midle sternotomy and verification laesio pericardii under right cordis longth of 20 mm,hematopericard and vulnus at parietis diaphragmalis right ventricular in area septoapicalis.Past evacuation sangui from pericard heart mobilisation and made compresion phingin.Placement closure laesion with cardiorraphia prolen 0000 sec.Cooley.Lesion right pleurae mediastinalis and placement drain in right torasic cavum and drain mediastine in restrosternal area i aspiration undervother sec. Bilay. Fixation sternum with fillum metalicum sec. Kurschner. Reanimation intensive care all time and past realisation complete haemostasis along linae sutturae heart folow up substitution adecquat failure volumen total sangui plasm and cristolid. Realisation total stability hemodinamic and patient move at department intensive care. Control EKG, echocardiography and cardiac ensims 5 and 10 dely psotoperative show fingins corectly. Not signs ischemic laesaoin and disfunction conducti and arrhythmi. Haert pariets is all corectly viability and cinesy.
SOME ASPECTS OF FAMILY PLANNING - FROM MISCARRIAGE TO HEALTH EDUCATION
Authors: Radojević J. , Stanišić S. , Stanojević D. , Jurišić A , Rakić S. , Matejić S.
Published: November 2024

Family planning is a civilizational value that should lead to a reduction of abortions, especially abortion as a method of family planning. Contraception or pregnancy prevention is the most purposeful way of birth control. It includes all the means and methods to a certain point, and certainly before the implantation of blastocyst, they stop the natural process of reproduction. The aim of our study is to analyze the application of some method of contraception among women who had and who had an early abortion in the sample and to analyze the application of some method of contraception in the study group of women and their correlation with the attendance of education in counseling contraceptive after intentional interruption of early pregnancy. A significant change in the use of contraceptive after pregnancy termination, and conducted training in family planning, is that the increased incidence of permanent contraceptive methods, compared to their occasional use.
CYTOLOGIC EXAMINATION IN DIAGNOSIS OF ORAL HERPES SIMPLEX VIRUS-1 INFECOIONS
Authors: Šehalić M. , Knežević M. , Mitić R. , Marjanović D. , Stamatović D. , Šubarić Lj. , Živković D. , Mitić N.
Published: November 2024

The nature of herpes simplex virus as infective agens, which can grow in number, only in live cells, and fact that many herpes virus infections of oral tissue have atypic and asymptomatic course, makes their diagnosis more difficult and complicate from infections caused by other microorganisms. The aim of this investigation were to established cytological findings oral lesions of primary and recurrent herpes infections.
ADIPOKINES AS FOR RUNNERS OF INFLAMMATORY CITOKINE SUPERFAMILY AND ITS INVOLVEMENT IN INFLAMMATORY AND IMMUNE DISEASES
Authors: Smiljić Lj. , Radunović M. , Muratović M. , Smilić T.
Published: November 2024

Leptin was discovered in 1994, finding, that marked the beginning of a new understanding about white adipose tissue. Up to end of 20th century this tissue was viewed as an inert tissue, devoted to body protection from heat loss and to passively store energy. This static vision, changed with identification of the product of the gene obese (ob) wich accentuated the role of adipose tissue in the physiopathology of obesity-linked diseases, and led to the discovery of various adipokines, many of a pro-inflammatory nature. With emerged knowledge of (WAT)-derived adipokines, it is obvious that they can be now considered as the bond between obesity-related environmental causes, such as nutrition and lifestyle, and the biochemical shifts that lead to metabolic syndrome, inflammatory and/or autoimmune conditions, and rheumatic diseases. This paper deals with reviews of recent adipokine research, with particular emphasis to the role of leptin, adiponectin, resistin, and visfatin in chondrocyte function and skeleton, as well as in inflammatory and degenerative cartilage joint diseases.
PARAMETERS OF OXIDATIVE STRESS AND ANTIOXIDATIVE POWER IN THE AQUEOUS IN PATIENTS WITH DIABETES AND AGE- RELATED CATARACT
Authors: Đokić O. , Mirić D. , Jakšiċ V. , Mirković M. , Vukša D. , Stamenković D.
Published: November 2024

Any kind of ocular lens opacification is well known as cataract. Most cataracts are age-related, so called senile cataract. Cataractogenesis as process involves either pathological and natural aging processes. Chronical oxidative stress is considered as primary factor in age-related cataractogenesis. In this study we measured concentration of lipid hydroperoxides, sulfhydril groups (SH) and entire antioxidative capacity,as well as ocular superoxide dismutase and catalase activity in 11 subjects with diabetes mellitus (DM) type 2 and cataract and in 39 nondiabetic subjects with senile cataract. All patients underwent complete ophthalmological examination before they were surgically treated by phacoemulsifications. 0 During the intervention, aqueous sample in volume 0,2 was aspirated and refrigerated in -20 C and preparated for further biochemical analysis. Parameters of antioxidative power in diabetic subjects with cataract have decreased values (sulfhydril groups and antioxidative potential - FRAP test) in aqueous while one of lipid peroxidation product has increased value (lipid hyperoxide). Aqueous catalase activity in subjects with diabetes and senile cataract is remarkably higher compared with nondiabetic subjects (p<0.0.5). Oxydative stress and antioxidative capacity are well known risk factor in cataractogenesis but in DM 2 patients, oxydative stress is more intensive than in control group.
IMPORTANCE AND RESULTS OF TYMPANOMETRIC EXAMINATION IN THE DETECTION OF MIDDLE EAR DISEASES BY CHILDREN IN PRESCHOOL INSTITUTIONS
Authors: Andrić P.V. , Prodanović M. , Branović O.
Published: November 2024

The authors analysed the importance and results of tympanometric examination by children in preschool institutions of Kosovska Mitrovica, Zvecan, Zerovnica, Socanica, Leposavic, Lesak and Zubin Potok. Children underwent ENT examination, which included clinical ENT examination and accessory diagnostics methods: tympanometric exami-nation and bacteriological analyses of the nose and throat secret. Totally, it have examined 870 children. The most frequent cause of the middle ear impairment was Eustachian tube dysfunction or "willingness of the middle ear for disease" (50,5% cases). Rarely, it was transient effusion in the middle ear and serous otitis media (19,02%). The authors underline a great importance of tympanometric examination by preschool children in detection of middle ear diseases. 
CHARACTERISTICS OF ARTERIOVENOUS FISTULA FOR HAEMODIALYSIS IN DIABETICS AND OLDER PATIENTS
Authors: Stolić R. , Sovtić S. , Perić V. , Stolić D. , Jovanović A. , Mihailović B. , Milinić S. , Krdžić B. , Pajović S. , Šubarić-Gorgieva G.
Published: November 2024

Formation of vascular access in elderly and diabetic patients is burdened with many difficulties. The aim of this study was to determine the factors that older people and patients with diabetes mellitus defined as the population risk for the formation of arteriovenous fistula for hemodialysis. The study was organized as a retrospective study, a subject of interest in people older than 65 years of age and diabetes, which in four years because of the need for further treatment performed arteriovenous fistula. Analyzed the demographic structure of the patient, type of anastomosis, the use of central-venous catheters for hemodialysis, arterial blood pressure and size of the lumen of blood vessels used for anastomosis, intraoperative measured. From the laboratory analysis determined the routine hematological and biochemical parameters. In relation to the positioning of arteriovenous fistula (p=0.033), the placement of catheters for hemodialysis (p=0.0009), preventive form of vascular access (p=0.04) and values of systolic (p=0.0001) and diastolic (p=0.0001) arterial blood pressure, achieved a statistically significant difference. Patients with diabetic nephropathy, compared to the population of elderly, have a significantly higher number of leukocytes (7.5±2.61 vs. 8.5±3.24, p=0.03), fibrinogen level (5.57±2.39 vs. 6.8±1.71, p=0.036), glycemia (5.35±1.24 vs. 7.1±2.28, p<0.0001), cholesterol (3.77±1 , 03 vs. 4.5±1.71, p=0.001), triglycerides (1.59 ±0.62 vs. 1.86±0.76, p=0.009) and LDL-cholesterol (2.13±0.76 vs. 2.42±2.04, p=0.02). Total proteins (64±9.98 vs. 62 ±7.4, p=0.027) and albumin (36±34 vs. 9.55±5.49, p=0.037) were significantly lower values in diabetics. Characteristics of older diabetics and is characterized as a risk population of patients for the creation of arterio-fistula were timely creation and position of arterio fistula, the need for placement of central-venous catheters for hemodialysis and arterial blood pressure.
COMPRESSIVE OSTEOSYNTHESIS AND BONE OSTEOPLASTICS AS METHODS IN TREATMENT OF BONES PSEUDOARTHROSIS
Authors: Vasić A. , Jakšiċ M. , Adžić V. , Božović A. , Petrović M.D. , Jakšiċ Lj. , Radojević G. , Nestorović V.
Published: November 2024

The pseudoarthrosis is a pathological state of the bone when the refracted bone fragments are not connected by bone callus. The causes for the occurrence of the pseudoarthrosis may be general and lokal.In treatment we were using two methods: the bone plastic and osteosynthesis and compression osteosynthesis by Ilizarov. The aim of this work is the analysis of patients with pseudoarthrosis and results of treatment. The study included 29 patients treated for the past ten years the Department of Orthopedics Health Center Z.C.Kosovska Mitrovica.The most frequently pseudoarthrosis were in humerusu 6 (21%), ulna 6 (21%) and skafoidne bone 6 (21%). The pseudoarthrosis in tibia was treated in 4 (14%) patients, in the femur 3 (10%) patients. 2 (7%) of the patients were operated with diagnosis the medial-maleolus pseudoarthrosis of the tibia fractures and 1 (3%) patient were operated with diagnosis the maleolus pseudoarthrosis of the fibula and of the radius.We were using the treatment methods osteoplastic and osteosynthesis for 28 (97%) patients and one patient was treated with the device by Ilizarov method. Patients were monitored by the clinical way, by the radiographic way ,by laboratory way and by the functional way The average time of the monitoring was ten months .The average time of the healing was the five months. We noticed the one complications only, a lesion of the radius, which is repaired. The pseudoarthrosis is not common, in our material it is 4% of the total number of the operated patients.The most frequently pseudoarthrosis was on humerous 21% (6 patients). By applying the compressive osteosynthesis methods and osteoplastic method we have achieved the completely curring in 89% (26 operated patients). 
EXTERNAL FIXATION OF COMMINUTED FRACTURES OF ANCLE - CASE REPORT
Authors: Grbić R. , Božović A.
Published: November 2024

Cominution of bone fragments and weakness of soft tissues dominate in cominuted fractures of ancle joint. This conditions representing big problem for proper osteofixation. Authors demonstrated external fixation tip Mitkoviæ for operative treatment of cominuted fractures of ancle in two patients. In both cases they achieved excellent functional outcome (by AOFAS score). This method distinguish easily aplication, stability of bone fragments, good biodynamic conditions. Those caracteristics provide optimal conditions for bone healing and authors recomended this method for treatment cominuted fratures of ancle.
APPLICATION OF BREDENT MINI DENTAL IMPLANTS (MDI) IN TREATING TOTAL TOOTHLESS LOWER JAW - CASE REPORT
Authors: Vlahović Z. , Mihailović B. , Todić J. , Dubovina D.
Published: November 2024

Introduction: Upon teeth are lost, morphological and functional disorders are caused on stomatognathic system. Since a longer period of time, total dentures made on conventional way were the best choice for treating toothless patients. Because of specific configuration of the toothless lower jaw, patients with total dentures mostly suffer problems with lower jaw total denture. From the time when osseointegration was applied as a successful clinical concept, implants have been used as well as for retention and stabilization of the total dentures. Case report: 66 years old male patient underwent surgery where implant-prosthetics rehabilitation of lower jaw is attained with application of four Bredent mini implants, used for retention and rehabilitation of total acrylic denture. The overall process was completed in one session within approximately one and a half hours, with the regular post surgical care and immediate load of implants. Conclusion: Taking into consideration simplicity, safety and non invasive procedure of placing mini implants, as well as their effect on improving quality of life of toothless patients, and economic aspect, we can conclude that along with classical and small implants they present future and method of choice for the rehabilitation of toothless patients.
PERIACINAR CLEFTINGS IN PROSTATIC ADENOCARCINOMA, PROSTATIC INTRAEPITHELIAL NEOPLASIA AND BENIGN HYPERPLASIA OF PROSTATE
Authors: Vančentović-Mijović M. , Vukićević D. , Mitić N. , Ðerković B. , Knežević M.
Published: November 2024

Diagnosis of different pathohystological diseases of prostate in the most cases based on common benignant and malignant characteristics. The presence of periacinar cleftings (PC) is an additional criterion favouring prostatic adenocarcinoma. The aim of our work was to examine the presence of PC around glands in prostatic adenocarcinoma (PA), prostatic intraepithelial neoplasia (PIN) and benign hyperplasia of prostate (BHP) and to determinate specificity and sensitiveness for their presence in PA. We analysed biopsy material of Institute of pathology, Medical faculty Priština and Department of pathology and forensic medicine Clinical center of Kragujevac from begining of 2007. till the end of 2008. According to the presence and extent of PC, analysed on high power field (400x), glands were classified as: group 1 - glands without PC or with PC affecting ≤50% of gland circumference; group 2 - glands with PC affecting >50% gland circumference in <50% examined glands and group 3 - glands with PC affecting >50% gland circumference in ≥50% examined glands. By the analyse of our material we found PC around glands in PA, PIN and BHP: the most glands in PA were group 2 (34 or 48,6%) and group 3 (31 or 44,3%), in PIN group 1 (12 or 60%) and group 2 (8 or 40%), in BHP glands at all 100% cases were group 1. We found sensitiveness 92,9% and specificity 73,3% for glands with PC at prostatic adenocarcinoma, which indicate that periacinar cleftings represent a reliable criterion in diagnosis prostatic adenocarcinoma. 
THE ASSESSMENT OF BIOLOGICAL EQUIVALENCE (BIOEQUIVALENCE) OF DRUGS BASED ON THEIR PHARMACODYNAMIC VARIABLES
Authors: Mitić R. , Stanojević Z. , Popović J.
Published: November 2024

Biological equality assessments are carried out by means of: a) comparative pharmacokinetic study; b) comparative pharmacodynamic study; c) controlled comparative clinical experimentation; d) comparative in vitro assay (dissolution test). The first method mentioned, i.e. determining the concentration of a drug in the blood of healthy volunteers, is the most accurate and most frequently employed. In this paper, a study conducted on healthy volunteers that displays the possibility of evaluating biological equality using pharmacodynamic variable data, giving the example of such assay of retard tablets of verapamil produced by two different companies, is presented. Taking into account the effects of this drug, biological equivalence was proved by comparing pharmacodynamic variables such as PR interval, systolic and diastolic blood pressure and heart rate.
MEDICAL APROACH PATIENTS WITH ORAL PLANOCELLULAR CARCINOMA
Authors: Račić A.J. , Filipović M. , Colić M. , Todorović M.
Published: November 2024

Planocellular carcinomas grow rapidly infiltrating the surrounding tissues. Because of that approach to the treatment of the patients must be multidisciplinary. A series of 101 patients with tongue and mouth floor carcinoma were analyzed. All were surgically treated in the period 2000. through 2007. The clinically evidenced local spread (cT) is highly correlated to the intraoperatively and patohistologically evidenced spread (pT) ~84%. The degree of correlation falls with increase of the T stage. The clinically evidenced regional spread (cN) and intraoperatively and patohistologically evidenced of regional spread (pN) presented lower in ~57% correlation then corresponding T categories. The study proves that multidisciplinary approach to the patients with oral carcinomas is the base for their proper treatment. 
METABOLISM AND INHALED ANESTHETIC ELIMINATION
Authors: Plačkić J. , Gvozdenović Lj. , Vojnović M. , Popović M. , Mitić R.
Published: November 2024

In this review paper, metabolism of most used inhaled halogenated anesthetics (halothane, enflurane, isoflurane, desulfurane and sevoflurane) is shown Only part of the anesthetics is metabolized, while the remainder is eliminated unchanged. They are metabolized by mixed function oxidases (reductive or oxidative pathways). 
THE INTERACTIONS OF BIOELEMENTS WITH INCREASED INTAKE OF COPPER
Authors: Vitošević B. , Jakovljević V. , Pavlović A.
Published: November 2024

Copper is an essential element, a constituent of all living cells and an integral component of many enzymes. The increase in pollution of the environment, and various metabolic diseases, imbalances biological processes and homeostatic regulated content of bioelements in the body. For the purpose of determining changes in the contents of bioelements with increased intake of copper, the paper followed by interaction before and after ingestion of copper. The results showed that copper in excess causes disruption of physiological interactions of bioelements in tissues and significantly increases the content of iron and magnesium. The nature and relationships of these interactions are important, because in terms of exposure to metals, there are changes in their mutual relations, with some of these antagonistic relationships may be utilized for further study in order to protect them from toxicity.
DOES DOXORUBICIN CONTAINING CHEMOTHERAPY CHANGE METABOLIC LIVER FUNCTION DURING TREATMENT OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA?
Authors: Kolarović J. , Konstantinidis N. , Kaćanski N. , Katanić J.
Published: November 2024

Doxorubicin is antitumor antibiotic extensively metabolized in the liver, and liver antioxidant capacity, including that provided by glutathione production. The aim of this study was to investigate whether doxorubicin containing chemotherapy changes metabolic liver function during treatment of childhood acute lymphoblastic leukaemia. Total protein concentration in serum, concentration of total, conjugated and non conjugated bilirubin, activity of aspartat aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (ãGT), lactate dehydrogenase and creatin kinase activity were measured before and after treatment with doxorubicin containing chemotherapy and in the control group. Caffeine was applied as metabolic marker via controlled consummation of Coca-Cola and 8-hour urine was collected immediately afterwards. In the collected samples, urinary thioethers and caffeine metabolites concentrations were measured. Chemotherapeutic regiment established for initial treatment of childhood ALL containing prednisone, vincristine, doxorubicin and L-asparaginase did not alter metabolic liver function. This regiment did not change liver enzyme activity. Applied chemotherapy also did not alter caffeine biotransformation, but it did increase urinary thioethers excretion. 
CLINICAL MANIFESTATION OF SUPRATENTORIAL BRANE INFARCT COMPARED TO INFARCT ZONE LOCALIZATION
Authors: Filipović S. , Mitrović V. , Petrović N. , Ljuši D.
Published: November 2024

Epidemiological characteristics of acute stroke certify the great importance of such disease, which takes the measures of a mass incontagious illness, because it represents one of leading causes of death and invalidity in the world. Contemporary knowledge about the complexity of cerebral infarct has been significantly increased thanks to new imaging methods, which allows correction of clinicaly stated diagnose. The aim of our research was to determine clinical manifestation signs of supratentorial infarcts and their presence compared to anatomic localisations of lesions. 60 patients were clinicaly tested, and a computerised tomografy of brain followed, which disclosed anatomic localisation of lesions. Results have shown that the maniestation of supratentorial infarct in the AMC zone has the most neurological signs, from conscious state disorders, graver pyramid deficit, speaking disorder to hemihypesthesia and hemianopsys. Lighter neurological deficit is found in infarcts which affect AAC and APC zones, which brings to a conclusion that knowing the clinical state and without applying neuroradiological methods can imply to localisation of supratentorial infarcts.
AN ULTRASOUND DETERMINED FREQUENCY AND VULNERABILITY OF PLAQUES ON CAROTID ARTERIES IN PATIENTS WITH DIABETES MELITUS TYPE 2
Authors: Smuljić M. , Jovanović A.
Published: November 2024

Even 1000 years BC the famous Persian physician Aviccena describet the first time gangrene diabetes mellitus as a complication. Basic pathohistological substrate vascular complication is atherosclerotic plaqueand therefore is an adequate treatment opf patients with vascular disease is conditioned by timely and precise diagnosis.The introduction of ultrasound technology in clinical practice enabled Edler and Hertz when the shou moves infarction 1954th,a then and Yoshida (1956.) and Sotomura (1959.), Frenklin (1961.) who are using ultrasound display of blood flow in the courts of man. The aim of our study was to deterimne the frequency of occurrences of atherosclerotic plaque in the carotid arteries and ultrasound examination of differences in the variability of certain plaques between patients with diabetes mellitus type 2 and healthy subjects. The examination was attended by a total of 82 people divided into two group. In first group they are 51 persons suffering from diabetes mellitus type 2 in to second control, the number of healthy respondents was 31. Among our respondents, a significantly higher incidence and plaque vulnerability was ina group of patients with diabetes mellitus type 2. 
ENDOMETRIAL HYPERPLASIA AND POLYPS
Authors: Vukićević D. , Mitić N. , Mijović M. , Đerković B.
Published: November 2024

Endometrial hyperplasia appears like a result of continues, not mortified stimulation of endometrial by estrogenically hormones. Endometrial becomes nub which histological mirrors in endometrial gland multiplication, in smaller amount even endometrial strom. Endometrial polyp represents focal overmuch growth of gland stromas endometrial and its considered a focal endometrial hyperplasia. Therefore we will examine them at the same time. Medical faculty of Prishtina - Kosovska Mitrovica did an analysis of biopsy and operational material in pathology institute in the period from 2005 to 2008 out of 3696 histological proved cases, its recorded that 210 cases have endometrial hyperplasia and endometrial polyp, which is 5,68%. According histological type the most often seen is endometrii hyperplasia simplex who is spotted in 127 cases (60,48% - D= 0,195; p<0,001), endometrii hyperplasia complex in 19 cases (9,09%), cases where endometrial hyper-plasia and endometrial polyps are united are spotted in 14 cases (6,67%), while endometrii polypus in 50 cases (23,81%). By analysis of all types of endometrial hyperplasia and endometrial polyps we came to conclusion that all of these changes are mostly made at the age of 41-50 (60,48%) compared to other ages. (D=0,267; p<0,001). In between all patients the youngest was 22 years old (endometrii hyperplasia simplex) and the oldest 78 years old (endometrii polypus). On the basics of studied values, regression's analysis it's been confirmed that the numbers of cases with endometrial hyperplasia and endometrial polyps are growing for 8,6 every year, which points at bigger and bigger problem in the whole pathology.
THE ALERGIC INFLAMMATION OF RESPIRATORY TRACT (INFLAMMATION IN CONTINUITY)
Authors: Krdžić B. , Mihailović B. , Milovanović J. , Čelić D. , Mirić M. , Krdžić M. , Šipić M.
Published: November 2024

Allergic disease are actual pathologic condition in medicine. From this diseases can get ill people of any age, both sex, and the number of patients with allergic diseases rapidly increase in countries of progressive world. This disease are wide - spread, with tendency of increase, and they can have fatal result in extreme cases. Because of high prevalence of morbidity and complications they have, allergic diseases are health problem. According to World allergic organization, more than 40 % of population in world will be atopic. In our environment this diseases are increasing, because of bad ecological condition from one side, and from the other side of genetic influence, and on the top of ladder are allergic diseases of respiratory system. The mayor key process in atopia is continuous and plentiful production of IgE antibody. 
HYPERKALEMIA - A CASE REPORT
Authors: Lazić S. , Čelić D. , Marčetić Z. , Sovtić S. , Stolić R. , Perić V. , Šipić M. , Krdžić B.
Published: November 2024

In clinical hyperkalemia, correlation between plasma K and the ECG is less reliable. A tall, peaked, symmetrical T wave with a narrow base, the so-called "tented" T wave is the earlinest ECG abnormality, usually best seen in leads II, III, V2, V3, and V4. The tented appearance and the narrow base are probably more characteristic of hyperkalemia than is the amplitude of the T wave. A decrease in amplitude of the R wave, appearance of a prominent S wave, widening of the QRS complex, depression of the ST segment evolve as plasma K approaches 8-9m Eq/liter. With hyperkaliemia, depression of intraventricular conduction is characteristically diffuse and results in prolongation of both the initial and terminal parts of the QRS complex. The resulting pattern may resemble RBBB, LBBB, left anterior or posterior divisional block, or a combination of the four.
CONSERVATIVE CARE OF ENDODONTIC TREATED TEETH WITH GREAT DAMAGE OF CROWN- REVIEW OF FOUR PRACTIC CASE
Authors: Živković D. , Matvijenko V. , Živković M. , Perić D. , Jovanović R. , Miladinović M. , Milosavljević Z. , Staletović M. , Radosavljević R. , Gligorijević N.
Published: November 2024

There are different stick types and shapes, different root canal preparation techniques, as well as different materials for stick cementing and making annexes around posts. The use of fiber-reinforced resin posts to restore endodontically treated teeth has gained popularity due to its mechanical and esthetic characteristics as well as properties of modern adhesive systems. The aim of this article was to show a clinical technique to reconstruct endodontically treated teeth with great loss of tooth structure using direct fiber-reinforced post systems and direct composite restorations. After the preparation of the root canal and cementation of a FRR post, particular attention was paid to the incremental and curing techniques adopted to reconstruct coronal part of the tooth. It is possible to place of fiber-reinforced resin posts. 