bluuebunny/crossref_metadata_2025 huggingface dataset:
Three-parameter prestack nonlinear inversion constrained by gradient structure similarity
Authors: Wang Zhiqiang , Gao Jinghuai , Zhao Haixia , Zhao Xiaolong
Published: October 2022

Estimating the elastic parameters from prestack inversion is of great importance for reservoir characterization. Conventional three-parameter prestack inversion methods rely heavily on well logs, and it is difficult to obtain reliable inversion results in situations with limited numbers of wells. Alternatively, we have developed a joint inversion strategy, integrating the advantages of post- and prestack inversion, to deal with the situation. First, due to the high signal-to-noise ratio of poststack seismic data, the high-precision acoustic impedance (AI) inversion is conducted. Second, the exact Zoeppritz equation is used to establish the objective function of the prestack inversion. To better constrain the elastic parameters (P- and S-wave velocities and density), a new similarity measurement criterion, the gradient structure similarity (GSS), is defined to describe the structural similarity between the prestack inversion results and the inverted AI from the poststack inversion. Third, the LM optimization algorithm is used to solve the nonlinear objective function. Through the model test, we verify the effectiveness of our GSS regularization scheme. Some synthetic and field examples find that our method can provide more stable and accurate inverted results relative to the conventional prestack inversion methods.
Slow Uptake of an Effective Therapy: Patterns of Olanzapine Prescribing for Those Receiving Highly Emetogenic Chemotherapy
Authors: Childs Daniel S. , Helfinstine David A. , Sangaralingham Lindsey , Orme Jacob J. , O'Sullivan Ciara C. , Loprinzi Charles L. , Ruddy Kathryn J.
Published: October 2022

PURPOSE:

For the past 5 years, most major antiemesis guidelines have included olanzapine-containing regimens among the recommended options for prophylaxis with highly emetogenic chemotherapy (HEC). We analyzed the uptake of olanzapine in clinical practice and the changing composition of multidrug antiemetic regimens.

METHODS:

A retrospective analysis was performed using an OptumLabs deidentified database of medical and pharmacy claims, which was filtered for patients starting HEC in the interval of 2006 to Q2 of 2021. Descriptive statistics were used to analyze patient characteristics and year-by-year antiemetic prescribing patterns, coinciding with cycles 1 and 2 of chemotherapy.

RESULTS:

A total of 63,154 distinct patients were included. The median age was 58 years (range, 18-88). Breast (45.2%) and hematologic (20.8%) cancers were the most common diagnoses. In 2016, olanzapine was prescribed to 1.4% of patients with cycle 1 of HEC. Prescriptions increased modestly each year, and by 2021, 13.9% of patients received olanzapine with their first cycle of chemotherapy. An additional 5.7% of patients received olanzapine for breakthrough symptoms or enhanced prophylaxis during cycle 2. In 2021, more than three-quarters of patients were prescribed antiemetics in a guideline-concordant manner, with an olanzapine-containing quadruplet (12.2%), an NK1-receptor antagonist triplet (64.5%), or an olanzapine triplet (suppressed for small sample size).

CONCLUSION:

Despite inclusion in major antiemesis guidelines, there has been relatively slow uptake of olanzapine for prophylaxis with HEC. This finding highlights the challenges of disseminating information and keeping prescribing systems updated with the newest evidence in supportive oncology.
Dynamically regulated focal adhesions coordinate endothelial cell remodelling in developing vasculature
Authors: Chau Tevin C. Y. , Keyser Mikaela S. , Da Silva Jason A. , Morris Elysse K. , Yordanov Teodor E. , Duscyz Kinga P. , Paterson Scott , Yap Alpha S. , Hogan Benjamin M. , Lagendijk Anne Karine
Published: October 2022

The assembly of a mature vascular network involves coordinated endothelial cell (EC) shape changes, including the process of EC elongation. How EC elongation is dynamically regulated in vivo is not fully understood. Here, we have generated a zebrafish mutant that is deficient for the integrin adaptor protein Talin 1 (Tln1). Using a new focal adhesion (FA) marker line expressing endothelial Vinculinb-eGFP, we demonstrate that EC FAs function dynamically and are lost in our tln1 mutants, allowing us to uncouple the primary roles of FAs in EC morphogenesis from the secondary effects that occur due to systemic vessel failure or loss of blood flow. Tln1 loss led to compromised F-actin rearrangements, perturbed EC elongation and disrupted cell-cell junction linearisation in vessel remodelling. Finally, chemical induction of actin polymerisation restored actin dynamics and EC elongation during vascular morphogenesis. Together, we identify that FAs are essential for EC elongation and junction linearisation in flow-pressured vessels and that they influence actin polymerisation in cellular morphogenesis. These observations can explain the severely compromised vessel beds and vascular leakage observed in mutant models that lack integrin signalling.

This article has an associated ‘The people behind the papers’ interview.
Complementary roles for auxin and auxin signalling revealed by reverse engineering lateral root stable prebranch site formation
Authors: Santos Teixeira Joana , van den Berg Thea , ten Tusscher Kirsten
Published: October 2022

Priming is the process through which periodic elevations in auxin signalling prepattern future sites for lateral root formation, called prebranch sites. Thus far, the extent to which elevations in auxin concentration and/or auxin signalling are required for priming and prebranch site formation has remained a matter of debate. Recently, we discovered a reflux-and-growth mechanism for priming generating periodic elevations in auxin concentration that subsequently dissipate. Here, we reverse engineer a mechanism for prebranch site formation that translates these transient elevations into a persistent increase in auxin signalling, resolving the prior debate into a two-step process of auxin concentration-mediated initial signal and auxin signalling capacity-mediated memorization. A crucial aspect of the prebranch site formation mechanism is its activation in response to time-integrated rather than instantaneous auxin signalling. The proposed mechanism is demonstrated to be consistent with prebranch site auxin signalling dynamics, lateral inhibition, and symmetry-breaking mechanisms and perturbations in auxin homeostasis.
BIR POSITION STATEMENT: Governance requirements for Non-Medical referrers to radiology
Authors: Hughes Helen , Logan Cristiona , Webster Amanda , Hiles Peter
Published: October 2022

The ability to request clinical imaging is included in many advanced roles of health-care professionals in the UK and is seen as a useful component in ensuring patients receive the right care, by the right person, at the right time. In order that diagnostic imaging referrals are appropriate, timely and safely made, the British Institute of Radiology has produced a position statement on the governance requirements covering clinical imaging requests from non-medical referrers (NMRs). This document is intended to help define the role of a NMR and to ensure they are practising responsibly and safely, within professional and legal frameworks, as part of the wider interprofessional team.
i-tRAP (individual tRNA acylation PCR): a convenient method for selective quantification of tRNA charging
Authors: Tsukamoto Yusuke , Nakamura Yumi , Hirata Makoto , Sakate Ryuichi , Kimura Tomonori
Published: October 2022

Each transfer RNA (tRNA) is aminoacylated (charged) with a genetic codon-specific amino acid at its 3′ end. Charged tRNAs are primarily used for translation, whereas fluctuations in charged tRNA fractions are known to reflect cellular response to stress. Here we report the development of individual tRNA-acylation using PCR (i-tRAP), a convenient PCR-based method that can specifically quantify the individual tRNA charging ratio. In this i-tRAP method, demethylases remove base methylations which are problematic for reverse transcription reaction, and β-elimination reaction specifically removes the 3′ end of adenine residue in uncharged tRNA. Subsequent TaqMan MGB qRT-PCR can distinguish between cDNA of charged tRNA and uncharged tRNA. By using this method, we revealed that the charging ratio of tRNAGln(CUG) was changed in response to amino acid starvation and also the charging ratio of tRNAGln(CUG) in senescent cells was lower than in young cells under starvation conditions. i-tRAP can be applicable to the quantification of the charging ratio of various tRNAs, and provides a simple and convenient method for analyzing tRNA charging.
A Study on The Characteristics of The Raw Materials and The Manufacturing Techniques for Glassy Layers on The Wave-shaped Tiles Excavated from The Sacheonwangsa Temple Site
Authors: Kim Sehee , Kim Dongha
Published: October 2022

In this study, the material characteristics of glassy layers on the wave-shaped tiles excavated from the Sacheonwangsa Temple Site were identified, and the manufacturing techniques and their characteristics were examined. The samples were ten green glassy layers separated from tiles. These samples were 2.62 to 4.43 mm thick and were sorted light and dark green. As a result of quantitative analysis of green glassy layers, PbO was calculated from 73.0 to 78.9 wt.% (average 76.7 wt.%), SiO2 was calculated from 21.2 to 27.0 wt.% (average 23.3 wt.%). Therefore, it is presumed that high-lead glassy layers were made with high-purity silica stone and lead. In addition, as a result of comparing the correlation between lead isotope ratios and trace and rare earth elements in the glassy layers, it was confirmed that they were largely divided into two groups. It is presumed that it was manufactured by fixing the wave-shaped tiles that had completed firing to a frame, putting a molten glassy onto it, and cooling it. Based on these morphological and material characteristics, it is closer to the glass than the glaze.
Scientific Analysis and Conservation of Oracle Bone Excavated in Bokam-ri, Naju
Authors: Kim Min Jae , Lee Eun Ji
Published: October 2022

In this study, the materialistic characteristics were reviewed based on the conservation treatment and scientific analysis results obtained for the abdominal bones excavated during the 8th excavation survey of the remains of Bokam-ri, Naju. In divination, the animal’s scapula is typically dotted, and the tool used is called the oracle bone. The oracle bone excavated from the no. 6 spherical historical site was artificially damaged during the divination process. Exfoliation and degradation also occurred on the burial environments due to various factors such as earth pressure, freezing, and thawing. In the process of cleaning, an X-ray three-dimensional tomography analysis was performed to estimate the internal shape of the abdominal bone collected from the soil, and mesh-type data were extracted and applied to the preservation process. The data obtained through the 3D scanning process was prepared with a precise measurement drawing. The restored product of the oracle bone and the pedestal were 3D printed based on the modeling data so that they could be used for further research and exhibition. X-ray irradiation and X-ray digital imaging showed that the marks and cracks that were difficult to observe were accurately recorded. To identify the species of scapula used as a material for the oracle bone, the estimated group of mammals was compressed and a sample was produced. Then its morphological comparison was conducted, and it was estimated that the left scapula of a male wild boar was used as a fortune-telling tool.
Modelling computer assisted audit techniques (CAATs) in enhancing the Indonesian public sector
Authors: Purnamasari Pupung , Amran Noor Afza , Hartanto Rudy
Published: October 2022

Background: This study aims to examine public sector auditors' tendency to use somputer assisted audit techniques (CAATs) in managing their audit works.

Methods: A total of 400 questionnaires were distributed to auditors working in the public sectors in Central Java, West Java, and East Java. From the total, 225 questionnaires were returned and completed.  The Structural Equation Modelling (SEM) and Partial Least Square (PLS) were used to analyze the data.

Results: The empirical findings reveal that performance expectation and facilitating conditions have encouraged auditors to use CAATs in their works. Further, there is a positive influence between the intention to use and CAATs audit. This implies that auditors with an intention will be more open to using the CAATs optimally in achieving effective and efficient work. The utilization of CAATs in public services needs to have strong support from the government and positive attitudes from the auditors as the users of the system.

Conclusion: This study covers broad areas of Central Java, West Java, and East Java. Further, the findings add to the literature on emerging markets specifically for Indonesian government auditors' intention and appropriateness of using CAATs. The use of CAATs help to provide auditors information on the highest number of auditees involved in corruption.
Identification of the exuviae of larva from Teinopalpus aureus Mell, 1923 using the complete mitochondrial genome
Authors: Liu Lei-Lei , Zhang Li-Hua , Weng Guo-Hang , Wang Wei-Qin , Gong Xi-Cheng , Wang Shan-Biao , Zhang Shu-Sheng
Published: October 2022

Teinopalpus aureus Mell (Lepidoptera: Papilionidae) is distributed throughout China, Vietnam and Laos, and is listed as a Class I species in China. To identify whether the exuviae of larva is belonging to Teinopalpus aureus Mell, 1923 or not, and to compare the gene structure and genetic differences among the known populations, ten mitogenomes of T. aureus from the exuviae of larva collected in the Michelia maudiae were sequenced. This method of sequencing the mitogenomes of exuviae of larva can give us the chance to monitor the conservation of rare butterflies.

Ten mitogenomes of T. aureus showed typical gene arrangements and contained 13 protein-coding genes (PCGs), two ribosomal RNA genes (12S rRNA and 16S rRNA), 22 transfer RNA (tRNA) genes, and a non-coding control region (D-loop). The two haplotypes with one base different in T. aureus were found. We also conducted phylogenetic analyses including all different populations of T. aureus to assess the phylogenetic relationship of T. aureus. The lengths of the 12S rRNA and 16S rRNA genes from both haplotypes were 776 base pairs (bp) and 1,334 bp, respectively. The genetic distance of the ten samples was calculated as 0-0.000065 on the basis of the whole mitogenomes. T. aureus found in Taishun, Zhejiang province, China had a close phylogenetic relationship with the clade of T. aureus found in Pingshan, Jiangxi province, China, which was supported by neighbour-joining analysis.
Study of the protective effects of cyanocobalamin on methotrexate induced nephrotoxicity in rats
Authors: Abdulwahhab Rana Q. , Ali Alabdali Samara Muwafaq
Published: October 2022

Background: Methotrexate (MTX) is a chemotherapeutic drug, used mainly in many cancerous stages, inflammatory and auto-immune diseases, but its use has been limited by its nephrotoxicity. Cyanocobalamin is a water-soluble vitamin possessing nephro-protective properties. The aim of this study was to investigate the effect of cyanocobalamin on the nephrotoxicity of methotrexate.

Methods: In this study 42 albino adult female rats were used, divided into six groups each containing seven rats (n=7). First  group: Control group (Negative control), 7 rats were injected intraperitoneally with 0.5ml/kg/day NS. Second group: 7 rats were injected intraperitoneal with a single dose of methotrexate (20 mg/kg) for 4 days. Third Group: 7 rats were given intraperitoneal cyanocobalamin at a dose (1.5 mg/kg/day) for two weeks, fourth, fifth, sixth group: 7 rats from each group were injected intraperitoneal with different concentrations of cyanocobalamin (0.5, 1, 1.5 mg/kg /day) respectively for two weeks and MTX (20 mg/kg) which was injected only on day 11. On day 15, rats from all groups were euthanized, and blood samples were taken for biochemical tests, including evaluating serum urea and creatinine. The kidneys were extracted for histological investigation and evaluation of antioxidant (GSH) and oxidative stress (MDA) by using kidney tissue homogenates.

Results: This study revealed that kidney damage produced by the MTX (group II) is manifested by significantly elevated (P<0.05) urea and creatinine. On the contrary, the cyanocobalamin groups (IV, V, VI) significantly (P<0.05) reduced urea and creatinine. Renal antioxidant defense systems, such as reduced glutathione depleted by MTX therapy, were restored to normal levels by cyanocobalamin. Furthermore, cyanocobalamin reduced oxidative stress (MDA) and histologically reduced renal tissue injury induced by MTX.

Conclusions: In conclusion, the study revealed that cyanocobalamin has a nephroprotective action upon MTX-induced renal damage in rats; cyanocobalamin may offer a protective effect, such as antioxidant action.
A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins
Authors: Yagi Moeri , Miller Simon , Nagai Yoshiko , Inuki Shinsuke , Sato Ayato , Hirota Tsuyoshi
Published: October 2022

Background: Impairment of the circadian clock has been associated with numerous diseases, including sleep disorders and metabolic disease. Although small molecules that modulate clock function may form the basis of drug discovery of clock-related diseases, only a few compounds that selectively target core clock proteins have been identified. Three scaffolds were previously discovered as small-molecule activators of the clock protein Cryptochrome (CRY), and they have been providing powerful tools to understand and control the circadian clock system. Identifying new scaffolds will expand the possibilities of drug discovery.

Methods: A methylbenzimidazole derivative TH401 identified from cell-based circadian screens was characterized. Effects of TH401 on circadian rhythms were evaluated in cellular assays. Functional assays and X-ray crystallography were used to elucidate the effects of the compound on CRY1 and CRY2 isoforms.

Results: TH401 lengthened the period of circadian rhythms and stabilized both CRY1 and CRY2. The compound repressed Per2 reporter activity, which was reduced by Cry1 or Cry2 knockout and abolished by Cry1/Cry2 double knockout, indicating the dependence on CRY isoforms. Thermal shift assays showed slightly higher interaction of TH401 with CRY2 over CRY1. The crystal structure of CRY1 in complex with TH401 revealed a conformational change of the gatekeeper W399, which is involved in isoform-selectivity determination.

Conclusions: The present study identified a new small molecule TH401 that targets both CRY isoforms. This compound has expanded the chemical diversity of CRY activators, and will ultimately aid in the development of therapeutics against circadian clock-related disorders.
Anti-ischemic effect of Tamarindus indica L. seed extract against myocardial hypoxic injury
Authors: Surinkaew Sirirat , Mongkolpathumrat Podsawee , Nissapatorn Veeranoot , Kumphune Sarawut
Published: October 2022

Background: Ischemic heart disease is a leading cause of death in patients with cardiovascular disease. Natural products containing high antioxidant activity have been used as an alternative therapy to improve the living conditions of patients. In this study, we examine the protective effect of tamarind seed (TS) on myocardial hypoxic injury.

Methods: The hypoxia model was mimicked by mineral oil overlayed on H9c2 cardiomyoblasts for 4 h. TS extract was pretreated and administered during the hypoxic condition. Radical scavenging activity of TS extract was measured and exhibited very potent antioxidant activities on 2,2-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assays.

Results: TS extract at a concentration of 10 µg/ml significantly reversed the effect of hypoxia-induced cell death and intracellular reactive oxygen species (ROS) production. We also observed hypoxia-induced over-expression of both inflammatory cytokine mRNA and activation of cellular apoptosis. Pretreatment of TS extract significantly reduced hypoxia-induced HIF-1α and pro-inflammatory cytokine production, IL-1β and IL-6. The Western blot analysis for apoptotic regulatory molecules, caspase 3, caspase 8 and Bax proteins, also showed hypoxic injury reversal by TS extract treatment.

Conclusions: The results suggest that the anti-ischemic effect of TS extract protects against hypoxia-induced injury and has potential to be an effective alternative therapy for ischemic heart disease and oxidative-damage related disease.
Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health
Authors: Kim Eunju , Yoo Seung-Hee , Chen Zheng
Published: October 2022

The circadian clock is a fundamental biological mechanism that orchestrates essential cellular and physiological processes to optimize fitness and health. The basic functional unit is the cell-autonomous oscillator, consisting of intersecting negative feedback loops. Whereas the core loop is primarily responsible for rhythm generation, auxiliary loops, most notably the secondary or stabilization loop, play pivotal roles to confer temporal precision and molecular robustness. The stabilization loop contains opposing nuclear receptor subfamilies REV-ERBs and retinoic acid receptor-related orphan receptors (RORs), competing to modulate rhythmic expression of the basic helix-loop-helix ARNT like 1 (Bmal1) genes in the core loop as well as other clock-controlled genes. Therefore, REV-ERBs and RORs are strategically located to interface the oscillator and the global transcriptomic network, promoting cellular homeostasis and physiological fitness throughout lifespan. Disruption of REV-ERB and ROR functions has been linked with diseases and aging, and pharmacological manipulation of these factors has shown promise in various mouse disease models. Nobiletin is a natural compound that directly binds to and activates RORα/γ, modulating circadian rhythms, and shows robust in vivo efficacies to combat clock-associated pathophysiologies and age-related decline. Results from several studies demonstrate an inverse relation between nobiletin efficacy and clock functional state, where nobiletin elicits little effect in young and healthy mice with growing efficacy as the clock is perturbed by environmental and genetic challenges. This mode of action is consistent with the function of the stabilization loop to promote circadian and physiological resilience. Future studies should further investigate the function and mechanism of REV-ERBs and RORs, and test strategies targeting these factors against disease and aging.
PDBrt: A free database of complexes with measured drug-target residence time
Authors: Ługowska Magdalena , Pacholczyk Marcin
Published: October 2022

Background: Difficulties in translating the in vitro potency determined by cellular assays into in vivo efficacy in living organisms complicates the design and development of drugs. However,  the residence time of a drug in its molecular target is becoming a key parameter in the design and optimization of new drugs, as recent studies show that residence time can reliably predict drug efficacy in vivo. Experimental approaches to binding kinetics and target ligand complex solutions are currently available, but known bioinformatics databases do not usually report information about the ligand residence time in its molecular target.

Methods: To extend existing databases we developed the Protein Data Bank (PDB) residence time database (PDBrt) which reports drug residence time. The database is implemented as an open access web-based tool. The front end uses Bootstrap with Hypertext Markup Language (HTML), jQuery for the interface and 3Dmol.js to visualize the complexes. The server-side code uses Python web application framework, Django Rest Framework and backend database PostgreSQL.

Results: The PDBrt database is a free, non-commercial repository for 3D protein-ligand complex data, including the measured ligand residence time inside the binding pocket of the specific biological macromolecules as deposited in The Protein Data Bank. The PDBrt database contains information about both the protein and the ligand separately, as well as the protein-ligand complex, binding kinetics, and time of the ligand residence inside the protein binding site.

Availability: https://pdbrt.polsl.pl
Maternal reports of morbidity during the index ALSPAC pregnancy
Authors: Ellis Genette , Fraser Abigail , Golding Jean , Iles-Caven Yasmin , Northstone Kate
Published: October 2022

Within the ALSPAC (Avon Longitudinal Study of Parents and Children) resource, information concerning the health of the mother during pregnancy is available from three sources: (i) computerised data collected by midwives after the birth of the baby, known as the STORK database; (ii) data abstracted by ALSPAC staff from detailed medical obstetric records, and (iii) reports by mothers during pregnancy, and shortly after the birth using structured questionnaires completed at home. In this Data Note we focus on source (iii), and detail the information obtained from these mothers concerning their health, signs and symptoms together with medications and supplements taken during pregnancy. We also describe how the data can be accessed.
Wprowadzenie
Authors: Sulik Monika
Published: October 2022

Pytania o tożsamość andragogiki wracają jak bumerang, są nieodłącznym elementem refleksji humanistycznej wielu teoretyków i badaczy. Nie bez znaczenia jednak jest przestrzeń podejmowanej refleksji i oczywiście osoby ją podejmujące, czego przykładem jest oddawany właśnie w Państwa ręce numer „Edukacji Dorosłych”. W tym miejscu szczególnej mocy nabierają słowa Ryszarda Koziołka, który w swym eseju „Humanista sygnalista” pisze: „Można to zrobić tak: wziąć kawałek literatury, skierować go w stronę niepokojącego fragmentu rzeczywistości i utworzyć między nimi połączenie alarmowe. Jeśli nam się powiedzie, w świadomości czytającego współobywatela rozlegnie się ostrzegawczy dźwięk rozpoznania, że oto nasza współczesność została przewidziana przez pisarza z przeszłości (Koziołek, 2019, s. 7)”. Poszukiwanie tropów i znaczeń w literaturze z zakresu szeroko rozumianej humanistyki, szacunek do tradycji, ale też umiejętność konfrontowania swej refleksji z współczesnością – tym właśnie w moim przekonaniu charakteryzują się teksty składające się na bieżący numer „Edukacji Dorosłych”, do którego lektury serdecznie Państwa zapraszam.
Kompetencja narracyjna w biegu życia człowieka
Authors: Mazurek Emilia
Published: October 2022

Człowiek żyje w świecie opowieści. Intensywna „kąpiel narracyjna” (Rostek, 2019, s. 131), jakiej poddawane jest dziecko już od pierwszych dni swojego życia, przyczynia się do rozwoju jego gotowości do słuchania opowieści, samodzielnego opowiadania, rozumienia i interpretowania. Od dzieciństwa rozpoczyna się zatem proces rozwoju kompetencji narracyjnej i może on trwać przez całe życie. Kompetencja narracyjna odnosi się zarówno do rozumienia już stworzonej narracji, jak i do samodzielnego jej tworzenia w różnorodnych sytuacjach komunikacyjnych. Zmienia się w biegu życia człowieka. W oparciu o przegląd literatury przedmiotu przedstawiono wybrane ustalenia teoretyczne i empiryczne dotyczące rozwoju kompetencji narracyjnej w okresie dzieciństwa, adolescencji i dorosłości.
Further development of the Affordances for Motor Behavior of Schoolchildren: standardized version and scoring system
Authors: Flôres Fábio Saraiva , Rodrigues Luis Paulo , Cordovil Rita
Published: October 2022

Mapping and evaluating regular contexts that schoolchildren attend is of great importance to understanding motor behavior. This communication aims to present the scoring system and standardization of the Affordances for Motor Behavior of Schoolchildren (AMBS), recently presented to the scientific and educational community. The AMBS was developed to assess children’s interdependent systems, such as home, school, and sports activities, that can influence 6 to 10-year-olds’ motor development, motor learning, and motor competence. The questionnaire was completed by 377 Brazilian families. Raw scores of each of the three subscales (home, materials, and school) were transformed into standard scores, ranging from very low to very high. AMBS subscales were classified as very low (1st quartile), low (2nd quartile), good (3rd quartile), and very good (4th quartile). The AMBS total raw score is a result of the sum of the three subscales standard scores and can be classified into three categories, ranging from a low to a high AMBS. Thus, AMBS total scores were classified as low (1st tercile), average (2nd tercile), and high (3rd tercile). We expect that raw and standard scores of the AMBS can be used by researchers, parents, and clinical/education professionals to assess children’s affordances for motor behavior.
Uveo-Meningitis and Myelodysplastic Syndrome
Authors: Ferrão Diana , Ribeirinho-Soares Pedro , Almeida Jorge
Published: October 2022

Uveo-meningeal syndromes are any disorder characterized by the involvement of the uvea and the meninges. They can have multiple causes, including infectious, autoimmune and malignant diseases. We report the case of a patient with a 10-year-old diagnosis of myelodysplastic syndrome that had been stable. He presented with new onset uveitis, ataxia, diplopia and fluctuating consciousness level, without any obvious cause revealed by brain imaging or blood chemistries. An extensive aetiological search showed no obvious cause. Initially, the patient improved spontaneously and was discharged. However, 2 months later, he deteriorated once again, this time with disperse adenomegalies that were not present previously. The bone marrow biopsy showed a high number of blasts, which affirmed the progression of the previously known myelodysplastic syndrome. The lymph nodes were not biopsied due to very low life expectancy, making the procedure futile. A presumptive diagnosis of uveo-meningitis caused by paraneoplastic syndrome was made. The patient died a few months later.
Cultural competence in occupational therapy to reduce health disparities: a systematic literature review
Authors: Crawley Rosie
Published: October 2022

Background/Aims

Despite agreement about the relationship between cultural competence and health equality, there is a lack of clear guidance within occupational therapy about what it means to be culturally competent and how it can be achieved. This literature review aims to critically appraise qualitative research to explore occupational therapists' experience of working cross culturally. By comparing these experiences, this review aims to identify ways in which occupational therapists individually, and occupational therapy as a profession, can increase the efficacy of the interventions they provide within cross-cultural situations, so all clients can be supported to achieve equal health outcomes.

Methods

The following databases were searched between 2010 and 2020: ASSIA (Applied Social Science Index), CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane, Embase, Medline Pubmed. The resultant papers were appraised using the Critical Appraisal Skills Programme checklist and thematic analysis was used to identify three themes.

Results

The six papers included in this review present the experiences of occupational therapists and occupational therapy students working in cross-cultural situations in the UK, Canada, South Africa, USA, Australia and Ireland. Three major themes emerged that explore the relationship between client-centred practice and cultural competence, theory–practice links, and strategies and barriers to working in a culturally competent way.

Conclusions

Cultural competence is strongly aligned with some of the core principles of occupational therapy: occupational justice and occupational identity. However, theoretical knowledge and confidence among occupational therapists in this area is lacking, implying that their impact could be greater if there was a more concrete definition of cultural competence and standardised guidelines for practice. Further research is needed to build on the strategies and overcome barriers, so that occupational therapists can fulfil the professional obligation they have to work effectively with all populations.
Latest clinical research
Authors: Greener Mark
Published: October 2022

The latest studies of interest to primary care clinicians rounded up by Mark Greener
The changing role of the chief compliance officer
Authors: Winchester Simon
Published: October 2022

Organisations are constantly challenged to reassess their position in the ever-changing business landscape. As this landscape changes, it arguably has the greatest impact on the role of the chief compliance officer, with the CCO playing an ever more crucial part in navigating the issues raised as a result of functional and operational challenges. Whether it's responding to the additional risks brought on by the pandemic, developing an approach to technology and data analytics that complies with ever-changing regulatory standards, or overseeing a remote or decentralised workforce, this all becomes a priority for the CCO. Amidst this backdrop, CCOs must be adaptable in order to take on a range of responsibilities.
Celebrating Optical Glass – the International Year of Glass (2022): feature issue introduction
Authors: Ballato John , Fotheringham Ulrich , Hubert Mathieu , Nolte Stefan , Petit Laeticia , Richardson Kathleen A.
Published: October 2022

We introduce the Optical Materials Express feature issue that celebrates historic and recent advances in optical glass. In honor of the United Nations declaring 2022 to be the International Year of Glass (IYOG), this issue comprises a collection of twenty-seven manuscripts that highlight processing, characterization/metrology and applications where glass has changed our world.
Deep learning for eavesdropper detection in free-space optical ON-OFF keying
Authors: Savino Nicholas J. , Lohani Sanjaya , Glasser Ryan T.
Published: October 2022

We demonstrate the efficacy of machine learning techniques in the detection of an eavesdropper in a free-space optical (FSO) communications setup. Experimentally, we use ON-OFF keying (OOK) and send strings of random bits through strong turbulence. When we apply a simulated eavesdropper to the bits in the post processing stage, a deep learning convolutional neural network (CNN) is able to successfully detect whether or not the eavesdropper is present. We vary the strength and duration of the attenuation of the simulated eavesdropper, and vary the signal-to-noise ratio (SNR) of the bit streams, and find that the strength of the eavesdropper has the greatest effect on eavesdropper detection accuracy. We are hopeful this flexible approach may be used in current and future operational FSO communications systems.
Network-based methods for psychometric data of eating disorders: A systematic review
Authors: Punzi Clara , Petti Manuela , Tieri Paolo
Published: October 2022

Background

Network science represents a powerful and increasingly promising method for studying complex real-world problems. In the last decade, it has been applied to psychometric data in the attempt to explain psychopathologies as complex systems of causally interconnected symptoms. One category of mental disorders, relevant for their severity, incidence and multifaceted structure, is that of eating disorders (EDs), serious disturbances that negatively affect a person’s eating behavior.

Aims

We aimed to review the corpus of psychometric network analysis methods by scrutinizing a large sample of network-based studies that exploit psychometric data related to EDs. A particular focus is given to the description of the methodologies for network estimation, network description and network stability analysis providing also a review of the statistical software packages currently used to carry out each phase of the network estimation and analysis workflow. Moreover, we try to highlight aspects with potential clinical impact such as core symptoms, influences of external factors, comorbidities, and related changes in network structure and connectivity across both time and subpopulations.

Methods

A systematic search was conducted (February 2022) on three different literature databases to identify 57 relevant research articles. The exclusion criteria comprehended studies not based on psychometric data, studies not using network analysis, studies with different aims or not focused on ED, and review articles.

Results

Almost all the selected 57 papers employed the same analytical procedures implemented in a collection ofRpackages specifically designed for psychometric network analysis and are mostly based on cross-sectional data retrieved from structured psychometric questionnaires, with just few exemptions of panel data. Most of them used the same techniques for all phases of their analysis. In particular, a pervasive use of the Gaussian Graphical Model with LASSO regularization was registered for in network estimation step. Among the clinically relevant results, we can include the fact that all papers found strong symptom interconnections between specific and nonspecific ED symptoms, suggesting that both types should therefore be addressed by clinical treatment.

Conclusions

We here presented the largest and most comprehensive review to date about psychometric network analysis methods. Although these methods still need solid validation in the clinical setting, they have already been able to show many strengths and important results, as well as great potentials and perspectives, which have been analyzed here to provide suggestions on their use and their possible improvement.
Emergence of Hopf bifurcation in an extended SIR dynamic
Authors: Roostaei Arash , Barzegar Hadi , Ghanbarnejad Fakhteh
Published: October 2022

In this paper, the original SIR model is improved by considering a new compartment, representing the hospitalization of critical cases. A system of differential equations with four blocks is developed to analyze the treatment of severe cases in an Intensive Care Unit (ICU). The outgoing rate of the infected individuals who survive is divided into nI and b I I + b where the second term represents the transition rate of critical cases that are hospitalized in ICU. The findings demonstrate the existence of forward, backward and Hopf bifurcations in various ranges of parameters.
Association of serum biomarkers with early neurologic improvement after intravenous thrombolysis in ischemic stroke
Authors: Cui Yu , Wang Xin-Hong , Zhao Yong , Chen Shao-Yuan , Sheng Bao-Ying , Wang Li-Hua , Chen Hui-Sheng
Published: October 2022

Background

Early neurologic improvement (ENI) after intravenous thrombolysis is associated with favorable outcome, but associated serum biomarkers were not fully determined. We aimed to investigate the issue based on a prospective cohort.

Methods

In INTRECIS study, five centers were designed to consecutively collect blood sample from enrolled patients. The patients with ENI and without ENI were matched by propensity score matching with a ratio of 1:1. Preset 49 biomarkers were measured through microarray analysis. Enrichment of gene ontology and pathway, and protein-protein interaction network were analyzed in the identified biomarkers.

Results

Of 358 patients, 19 patients with ENI were assigned to ENI group, while 19 matched patients without ENI were assigned to Non ENI group. A total of nine biomarkers were found different between two groups, in which serum levels of chemokine (C-C motif) ligand (CCL)-23, chemokine (C-X-C motif) ligand (CXCL)-12, insulin-like growth factor binding protein (IGFBP)-6, interleukin (IL)-5, lymphatic vessel endothelial hyaluronan receptor (LYVE)-1, plasminogen activator inhibitor (PAI)-1, platelet-derived growth factor (PDGF)-AA, suppression of tumorigenicity (ST)-2, and tumor necrosis factor (TNF)-α were higher in the ENI group, compared with those in the Non ENI group.

Conclusions

We found that serum levels of CCL-23, CXCL-12, IGFBP-6, IL-5, LYVE-1, PAI-1, PDGF-AA, ST-2, and TNF-α at admission were associated with post-thrombolytic ENI in stroke. The role of biomarkers warrants further investigation.

Trial registration

Clinical Trial Registration:https://www.clinicaltrials.gov; identifier:NCT02854592.
Transient unilateral exotropia after an infraorbital local anesthetic injection: a case report
Authors: Choi Woo Jung , Song Woo Jin
Published: October 2022

We report a case of transient unilateral exotropia, a rare complication that occurred after an infraorbital local anesthetic injection, and present the possible mechanism underlying this adverse effect. A 64-year-old man underwent an excisional biopsy under local anesthesia for bilateral lower eyelid masses. He received a subcutaneous injection of a local anesthetic (a combination of 1:100,000 epinephrine and 2% lidocaine). Intraoperatively, we observed a homogeneous, fat-attenuated mass with thin fibrous septae inside the orbital septum of each eye. Following excision of the masses, the patient developed severe diplopia accompanied by exotropia, impaired adduction, and mydriasis of the right eye. The pupillary light reflex, visual acuity, and visual field test results were within normal ranges. Notably, his symptoms completely resolved 4 hours postoperatively without intervention. To our knowledge, transient unilateral exotropia following infraorbital local anesthetic injection is rare. The exotropia was attributed to diffusion of the epinephrine/lidocaine solution, which may have affected the ciliary ganglion and the medial rectus muscle. Caution is warranted during local anesthetic injections in patients who undergo periorbital surgery.
An outbreak of devastating facial stigmata caused by a single unlicensed aesthetic practitioner
Authors: Jun Daiwon , Kim Daheui , Park Min Suk , Kim Young Jin , Lee Jung Ho
Published: October 2022

Background The practice of medicine by uncertified personnel is a common concern in public healthcare. Although the introduction of the Korean National Health Insurance Service has significantly reduced the number of these cases, the problem persists in the field of aesthetics. Herein, we report an outbreak of devastating facial stigmata in patients treated with illegal cosmetic procedures.Methods During 1 week in November 2021, five patients presented to Bucheon St. Mary’s Hospital for the management of identical patterns of severe facial scarring. Each patient had been treated for “skin rejuvenation” by a single unlicensed practitioner. Months of needling therapy by the practitioner, aimed at resolving the problem, only aggravated the scarring. The victims visited our hospital after the practitioner ceased to answer their calls. The patients had similar presentations with multiple prominent scars on both cheeks. Ectropion of the right lower eyelid due to scar contracture was observed in one patient.Results Five monthly treatments with intralesional triamcinolone injection and laser therapy were performed. Despite thorough management, the patients were left with improved but distinctive stigmata on their faces.Conclusions Cases of illegal aesthetic procedures are difficult to prosecute because the patients have implicitly agreed to the procedure. Therefore, active legislative measures should be adopted to prevent further victimization. Public education on the dangers of illegal aesthetic practices is also necessary.
A prospective comparison of prepectoral and subpectoral methods for immediate breast reconstruction with acellular dermal matrix: the cogwheel-shaped anterior wrapping method
Authors: Kim Sun Eung , Chun Yong Soon , Park Heung Kyu , Kim Yu Jin , Cheon Young Woo
Published: October 2022

Background Prepectoral breast reconstruction has recently gained wide recognition for its advantages, such as rapid recovery and less pain. This study compared the effectiveness of and differences between the prepectoral and subpectoral breast reconstruction techniques.Methods Eighty-three patients (90 breasts) who underwent prepectoral or subpectoral breast reconstruction surgery between January 2019 and December 2020 were prospectively recruited. Patient demographics, comorbidities, oncological treatment, and intraoperative and postoperative data were evaluated to investigate the validity and stability of each surgical technique. The follow-up period was a minimum of 18 months.Results The surgical cohorts (22 prepectoral and 68 subpectoral) had comparable demographics. No significant differences in postoperative complications were observed between the two groups. The prepectoral group showed shorter operation times than the subpectoral group (mean: 97.27 and 127.63 minutes, respectively; P<0.001). Fewer days elapsed until drain removal and the total amount of drainage was less in the prepectoral group than in the subpectoral group (mean: postoperative day [POD] 8.95 and 10.06, respectively; P=0.048) and (501.72 mL and 671.19 mL, respectively; P=0.009). The numeric pain rating scale (NPRS) scores at POD 7 were significantly lower in the prepectoral group than in the subpectoral group (mean: 0.41 and 1.82, respectively; P=0.029). There were no statistically significant differences in the NPRS scores at POD 1 or the BREAST-Q questionnaire scores at 3 months.Conclusions Prepectoral breast reconstruction using acellular dermal matrix can feasibly replace the conventional subpectoral breast reconstruction technique and has the advantages of reducing operation time, length of hospitalization, and long-term postoperative pain.
FASB to Practitioners: ‘Substance Over Form’ for Me but Not for Thee – An Apologia
Authors: Fischer Dov
Published: October 2022

This an apologia to Williams, P. F. (2022). The decline of substance over form in accounting: A problematic dichotomy. Accounting, Economics, and Law: A Convivium critique of Fischer, D., Ellman, O., & Schochet, S. (2021). The decline of substance over form in accounting. Accounting, Economics, and Law: A Convivium, 20190052 article about the decline of substance over form in accounting. The concept of “substance over form” has traditionally been a guiding principle for practicing accountants. In recent years, FASB has taken away the prerogative from individual practitioners to organically evolved GAAP. In the pre-FASB era, GAAP was indeed a bottom-up generally-accepted framework. Nowadays, FASB appropriates to itself the privilege to decide when form conforms with economic substance and when form should be bent to correspond to accounting theory.
Ferrate synthesis using NaOCl and its application for dye removal
Authors: Gunawan Gunawan , Prasetya Nor Basid Adiwibawa , Haris Abdul , Pratista Eka
Published: October 2022

Ferrate salt is a powerful oxidant for dye degradation. This work demonstrates a new method for degrading dyes containing Fe(vi) by synthesizing NaOCl from the electrolysis of table salt. NaOCl is then reacted with Fe(OH)3 in an alkaline condition to form ferrate. Electrolysis of table salt was successfully carried out using platinum as an anode and zinc as a cathode. The obtained ferrate was characterized by using Fourier transform infrared, UV-Vis, and X-ray diffraction spectroscopy. The ferrate solution has a maximum wavelength of 505 nm with a characteristic purple color. Furthermore, the ferrate produced was utilized to remove methylene blue (MB), remazol black blue (RBB), and methyl orange (MO) dyes with varying contact times. The degraded dyes were then analyzed using LC/MS. The results showed that ferrate was effective to remove dyes with an optimum contact time of 60 min that follows an order one reaction. In this study, MB showed a percent degradation close to 100% with the fastest decolorization rate compared with MO and RBB. This research provides new insights into the benefits of table salt as a base material for NaOCl through electrolysis for synthesizing ferrate, used in dye removal applications.