bluuebunny/crossref_metadata_2025 huggingface dataset:
Sosyal Medya Platformlarında Dijital Şiddet: Spor Bilimleri Öğrencileri Üzerine Karşılaştırmalı Bir Çalışma
Authors: ÇETİN Erdal
Published: February 2023

Bu çalışma spor bilimleri bölümlerinde okuyan öğrencilerin sosyal medya platformlarında maruz kaldıkları dijital şiddeti karşılaştırmalı olarak ele almaktadır. Örneklem grubunu Batman üniversitesi öğrencilerinin oluşturduğu çalışma için dijital şiddet eylemlerini konu alan bir anket uygulanmıştır. Anket sonuçlarına göre spor bilimlerinde okuyan öğrenciler, diğer bölümlerde okuyan öğrencilere göre daha fazla dijital şiddete maruz kalmıştır. Spor bilimleri öğrencilerinin en fazla maruz kaldıkları eylemlerin, sosyal medya veya e-posta hesap şifrelerinin istenmesi (%23,1), ısrarlı bir şekilde takip istekleri (%20,5), paylaşımlarında hakarete ve rahatsız edici yorumlara maruz kalma (%19,9) ve yazılı, görsel ve sözlü taciz mesajları alma (%16,5) olmuştur. Spor bilimleri bölümlerinde okuyan öğrenciler cinsiyet, etnik kimlik/ırk ve fiziksel özelliklerinin bu eylemlere maruz kalmalarında önemli bir faktör olduğunu beyan etmiştir. Bu eylemler karşısında aldıkları önlemler veya tepkiler sorulan öğrencilerin önemli bir kısmının bloklama ya da uygulama içinde şikâyet etme gibi seçeneklerini değerlendirdikleri; buna karşın sosyal önlemler veya hukuki girişimler konusunda zayıf tepkiler gösterdikleri belirlenmiştir.
Environmental attitudes of Chinese students in higher education institutions
Authors: Yue Xiaoyao , Wanglee Weichi , Yin Ying , Ye Yan , Cai Ting
Published: February 2023

This study investigates the influence of environmental attitudes of Chinese students in higher education institutions (HEIs). It included 988 students at ten higher education institutions and administered an “environmental attitudes inventory" questionnaire to investigate gender, grade level of study, institution level, parental educational background, scholarships, annual household income, students' leadership experience and the extent to which variables such as participation in environment-related courses affect students' attitudes towards the environment. Furthermore, the study relied on descriptive and analytical methods. The results show significant differences in grade, school level and parents' educational backgrounds on students' environmental attitudes. In contrast, gender, scholarship, annual family income and student leader experience related to the environment did not appear as significant factors. This paper suggests that education policymakers incorporate these influences into a vision of environmental educational reform to inform the remedial actions needed by higher education institutions.
THE RELATIONSHIP OF STRESS LEVEL WITH MENSTRUAL CYCLE IN MIDWIFE AT RSUD DR. SOETOMO DURING THE COVID-19 PANDEMIC
Authors: Suci Dwi Wulan , Purwanto Bambang , Atika
Published: February 2023

Background: An interrupted menstrual cycle can indicate reproductive system problems. However, there are several factors that can affect the length of the menstrual cycle such as nutritional status, diet, stress, hormonal drugs, smoking, and sleep quality. The current COVID-19 pandemic has had a major impact, one of which is an increase in stress, especially for health workers who serve COVID-19 problems. This study aims to analyze the relationship between stress levels with the length of the midwife's menstrual cycle during the COVID-19 pandemic. Methods: The type of research that will be used is an observational analytic study using a cross sectional design. The number of samples used were 47 midwives who work in RSUD Dr. Soetomo Surabaya during the COVID-19 pandemic. Bivariate analysis using Spearman tests. Results: There were 63.8% of midwives who had moderate stress levels and 88.2% of midwives with normal menstrual cycle length. The results of the analysis showed that there was no relationship between the midwife's stress level with the length of her menstrual cycle with p=0,660 and p = 0.568. Conclusion: Based on the results of this study, it can be concluded that there is no relationship between stress levels with the length of the menstrual cycle in midwives during the COVID-19 pandemic, so education and information about stress handling mechanisms are needed so that stress does not increase.
 Keywords: Stress level, menstrual cycle length, COVID-19 pandemic
POST COVID-19 VACCINATION ANXIETY IN MIDWIVES IN MIDWIFERY SERVICES AT INDEPENDENT MIDWIFERY PRACTICE
Authors: Amalia Putri Puspita , Prasetyo Budi , Anis Wahyul
Published: February 2023

Abstract
Background: Anxiety has been going on during the COVID-19 pandemic and can occur to anyone. Including midwives need to give services with direct physical contact for people who are susceptible to infection. As a solution against the pandemic, the COVID-19 vaccines rapidly developed to reduce the risk of COVID-19 transmission. With the presence of the COVID-19 Vaccines, this study aims to examine the anxiety of midwives after COVID-19 vaccination in midwifery services at IMP (Independent Midwifery Practice). Methods: Descriptive quantitative research with the number of respondents 137 midwives based on total sampling technique. The variable in this study is the level of anxiety measured by the 7-item Coronavirus Anxiety Scale. The data analysis with univariate analysis. Results: Based on the results, it shows of the 137 respondents who have been receiving the COVID-19 vaccine has found 46 respondents (33.6%) with normal category, 55 respondents (40.1%) with mild category, then moderate category as many as 23 respondents (16.8%), and severe category as many as 13 respondents (9.5%). Conclusion: most of the anxiety categories levels experienced are normal until mild. The possible causes are from the visitors who do not apply health protocols and the midwives who have families with susceptible group status.
Key words : anxiety, midwives, COVID-19 vaccination
EFFECT OF BREAST CARE IN PUBLIC WOMEN ON NEONATE WEIGHT INCREASE
Authors: Manurung Aurelia Margaretha , Martono Tri Utomo  , Woro Setia Ningtyas
Published: February 2023

Background: Breastcare is one of the interventions that can be done to increase and overcome the lack of breast milk so that it can rule out formula milk as an alternative. One of the signs that breast milk is finally in the sufficient phase can be seen in the baby's weight gain. The purpose of this study was to analyze the effect of breastcare on postpartum mothers on increasing neonatal weight at PMB Noris Hadi Boyolali. Methods: quasi-experimental research design with pretest-posttest control group design. The number of samples was 22 postpartum mothers with purposive sampling technique. The independent variable was breast care for postpartum mothers for the intervention group once a day from day 10-13 (a total of 4 times) and the control group once on day 10, the dependent variable was the increase in neonatal weight which was examined on days 10 and 14. The instruments used are SOP for postpartum mother's breastcare and baby scales. Data analysis used Wilcoxon test, paired t test, and Mann Whitney test. Results: The results of the analysis of the effect of breastcare on postpartum mothers on increasing neonatal weight with the Mann Whitney test obtained p value = 0.208, meaning that there is no effect of breastcare on postpartum mothers on increasing neonatal weight. Conclusions: There was no difference in neonatal weight before and after breastcare was given to postpartum mothers between groups. There was no effect of breastcare on postpartum mothers on the increase in weight of neonates statistically, but the increase in weight of neonates in the intervention group was greater than in the control group.
 
Keywords: breast milk, breast care, neonate weight
El “román idyllique” en el medievo francés: antecedentes, desarrollo y evolución. Obras representativas
Authors: García Peinado Miguel A.
Published: February 2023

El trabajo consiste en una revisión de los relatos idílicos del Medievo francés, que asocia a los amantes en el título. Tras desarrollar una taxonomía de los relatos que entrarían dentro de esta clasificación se analizan brevemente los más importantes: Erec et Enide, Floire et Bianchefor, Floris et Lyriopé, Aucassin ei Nicolette y Jehcm el Bionde.
A propósito de un fragmento hagiográfico castellano (siglos XIV-XV) Necesidad de la arqueología fuentística
Authors: Monferrer Sala Juan P.
Published: February 2023

Cruz, fuentes, leyenda, oriente.
Higino: balance crítico sobre un mitógrafo traducido, desaparecido y reencontrado
Authors: Urbán Ángel
Published: February 2023

El articulo intenta ser un balance o juicio crítico no sólo de un reciente comentario de Giulio Guidorízzi (Adelphi Edizioni, Milano 2000), sino también del propio Higino en cuanto mitógrafo. Se presentan los puntos más sobresalientes dei comentario, como también los más débiles. Se subrayan las informaciones mitográficas propias o exclusivas del texto de Higino, que en ciertos casos no han sido advertidas por Guidorizzi, indicando la importancia y alcance de algunas de ellas. También se exponen sus “errores”, algunos de los cuales tampoco han sido anotados en el comentario.
Introducción
Authors: LÓPEZ FOLGADO Vicente
Published: February 2023

Los prerrafaeiislas formaron un movimiento estético y literario inglés de mediados del siglo XIX, en el que convergieron en las mismas personas intereses artísticos de distinto carácter: pintores y artistas plásticos en sus inicios, cultivaron la poesía como parte esencial de la expresión estética de sus ideas y convicciones. En este estudio monográfico se traducen poemas o fragmentos de poemas de autores destacados que formaron parte de este grupo: Dante G. Rossctti, Christina Rossetti, William Morris y A. Charles Swinburne son los autores, que por su importancia, hemos abordado y traducido al español en este ‘dossier’.
La Littera Pythagorica, El simbolismo de la "Y” en la literatura y en el arte
Authors: ASENCIO GONZÁLEZ Emilio
Published: February 2023

Desde la Antigüedad Clásica la letra Y se consideró mucho más que una simple grafía. La llamada Littera Pythagorica, ya que su creación se atribuye desde antiguo al filósofo de Samos, se convirtió en el símbolo de la escuela pitagórica que más influyó en el arte, la literatura y el pensamiento posterior. Se tomó como alegoría de los caminos que el hombre debe elegir en su vida: el del vicio o el de la virtud. Pero el Renacimiento vio en la Y mucho más que una simple alegoría para la enseñanza ética o moral desde el punto de vista cristiano. Para los eruditos renacentistas la Littera Pythagorica se convirtió en icono y símbolo de la gran innovación de esta época: la expresión del libre albedrío, de la libertad del hombre para forjar su propio destino, del nuevo homo faber del Renacimiento.
“¿Para qué nos sirve la forma /que/?”
Authors: OSUNA GARCÍA Francisco
Published: February 2023

Este trabajo pretende clarificar la función semántica de la forma que. Para ello mostramos un resumen crítico de las diferentes explicaciones propuestas. A continuación tratamos de justificar que sólo tenemos dos tipos de que: uno con función semántica designativa como nominal demostrativo relativo, y otro como morfema auxiliar que modifica la función semántica del segmento al que se une. Con este criterio tratamos de identificar la función de la forma que en los casos considerados más problemáticos o, incluso, considerados anómalos.
Ciencia y ocultismo en el primer Lugones: cuatro cuentos
Authors: PEREA SILLER Francisco J.
Published: February 2023

En este artículo, se estudian cuatro cuentos de Leopoldo Lugones: “Kábala práctica” (1897), “El espejo negro” (1898), “Un fenómeno inexplicable” (1898) y “La fuerza Omega” (1906). En 1898, Lugones ingresa en la “Sociedad Teosófica” de Buenos Aires, y muestra su interés por la ciencia y el ocultismo, presente en sus primeros cuentos. También se tratan dos tópicos literarios: la creación de ambientes de Lugones y la oposición ciencia vs. ocultismo.
Terminología de la existencia en las metafísicas islámicas de la creación
Authors: BELTRÁN Miquel , FULLANA Guillema
Published: February 2023

Las traducciones que los árabes hicieron de textos de Plotino y Proclo, y que la tradición consideró pseudo-aristotélicos (como demuestra el titulo del principal entre ellos, la Teología de Aristóteles -en realidad un compendio de ciertos libros de las Enéadas-) tergiversaron la ontología de la Grecia clásica, basada en el ser, y la convirtieron en una metafísica de la existencia, basada en la doctrina monoteísta de la creación. En el artículo tratamos de mostrar cómo esto fue posible en buena parte gracias al previo bagaje terminológico de la lengua árabe, que permite diferenciar entre las funciones predicativa y existencial, y también entre la esencia y la existencia, de un modo que resultaba imposible en el seno de una ontología del ser.
La ciudad de Córdoba en el diario inédito de Giovan Battista Gornia, cronista de Cosme III de' Medici
Authors: DOMÍNGUEZ FERRO Ana M.
Published: February 2023

El futuro monarca florentino, Cosme III de' Medici, hijo del gran duque Fernando II y de Vittoria della Rovere, inicia en septiembre del año 1668, acompañado por una comitiva de alrededor de treinta personas, un viaje por varios países europeos, entre ellos España, con objeto de completar su formación y conocer de cerca las políticas y costumbres de estos países. En el presente artículo se analiza la visita que la comitiva florentina realiza a Córdoba, ciudad a la que llegan el sábado, 8 de diciembre de 1668, y de la que parten con destino a Granada el viernes, 14 de diciembre, a través del diario inédito del médico, Giovan Battista Gornia, que forma parte del séquito personal del heredero toscano y que elabora una crónica del viaje en la que se recogen las impresiones, los lugares que visitaron y los aspectos más interesantes de la estancia en la ciudad.
La sátira en el léxico gastronómico del Cancionero de Baena
Authors: LÓPEZ QUERO Salvador
Published: February 2023

Para el estudio de la sátira en el léxico gastronómico del Cancionero de Baena se han seleccionado los campos semánticos que, a continuación, se relacionan: el de ciertos guisos judios, otras comidas, pescados y carnes. Estos poetas se han servido de la sátira para establecer una oposición entre la buena y mala comida. Algunos de estos términos tienen un sentido irónico y figurado, además de documentarse por vez primera en esta obra.
Fuente Ovejuna: de la crónica al texto dramático
Authors: MONTERO Juan
Published: February 2023

La comedia de Lope ha convertido en mito unos hechos históricos que desembocaron, en 1416, en la muerte de Fernán Gómez, Comendador Mayor de Calatrava, a manos de los vecinos de Fuente-Obejuna, hechos cuya génesis y desarrollo no han podido ser completamente aclarados por los historiadores hasta el día de hoy. A partir de los relatos cronisticos y el conocimiento de la historiografía actual, se recompone el proceso que lleva a la conversión de la materia histórica en una comedia, siguiendo y alimentando los elementos de la leyenda.
Analyse eines prototypischen Tageliedes: Wolfram von Eschenbachs Siite Klhwerr
Authors: BALBUENA TOREZANO M. del Carmen
Published: February 2023

Hier werden wir beschreiben, welche typische Tageliedselemente sich in das bekannteste Tagelied Wolframs befinden. So werden wir den Ausgangspunkt, die personalen Konstituenten, die räumlichen und temporalen Elementen anaysieren, und wie alle diese Elemente intesive Gegensätze sind.
La pasíon y consolación teresianas: Teresa de Cartagena, mediadora del saber femenino
Authors: KIM Yonsoo
Published: February 2023

El padecimiento físico representa uno de los medios de propulsión intelectual femenina para romper los límites impuestos por la sociedad misógina de la Edad Media. A través de la Arboleda se ratifica que la tendencia ideológica y teórica de teresa de Cartagena conserva fuerzas positivas hacia el sufrimiento por la discapacidad de la sordera, mientras que en la práctica no pasaba lo mismo. Por eso, con diferentes discursos religiosos y médicos se manifiestan, explícita e implícitamente, la discriminación y marginalización con que convivía la autora a partir de su discapacidad física. Al combinar las connotaciones negativas de la sordera con los preceptos de la doctrina cristiana, la monja castellana logra imponer su escritura frente a la sociedad misógina.
La lingua castigliaina nel '500 tra lessicografia e traduzione. Alcune considerazioni sui 'glossarietti" spagnolo-italiano di Alfonso de Ulloa nell'Orlando Furioso in castigliano e nella Celestina (Venezia, Giolito, 1553)
Authors: LEFÈVRE Matteo
Published: February 2023

In questo articolo, partendo da una prospettiva storico-culturale oltre che linguistica, vengono analizzate alcune questioni inerenti alla traduzione italiano-spagnolo nel Rinascimento. In effeni, soprattutto a partire dai decenni centrali del Cinquecento, per andare incontro alle esigenze del pubblico spagnolo residente in Italia in seguito all'espansione dei domini di Carlo V, editori e stampatori si affannano per dare alla luce testi in lingua castigliana. Numerosi sono dunque i traduttori che lavorano al servizio delle tipografie italiane più .prestigiose e che, come nel caso di Alonso de Ulloa, oltre alle competenze squisitamente linguistiche dann altresi prova di una notevole coscienza lessicografica. A ciò si devono infatti i due brevi dizionari italiano-spagnolo che quest'ultimo inserisce al termine delle due edizioni della Celesfina e dell'Orlando furioso in castigliano del 1553, i quali rappresentano senza dubbio un vero e proprio gioiello della lessicografia rinascimentale.
Estruturas X-que e atuação metonímica: gramaticalização de tanto que no Português
Authors: LIMA-HERNANDES Maria Célia , LOPOMO DEFENDI Cristina
Published: February 2023

Este trabalho tem por objetivo precipuo a identificação de algumas rotas de gramaticalizaç ão de estruturas que envolvem a palavra tanto no português do Brasil à luz de uma subjacente categorização cognitiva (Heine, Claudi e Hünnemeyer, 1991). Tais estruturas, muitas vezes geradas por processos metonímicos, aproximam elementos que sintaticamente eram distantes na cadeia sintática e passam a constituir formalmente uma estrutura X-que. Em especial, este trabalho detém-se na identificação de rotas de uma mudança gramatical, incluindo-se ai o estudo das categorias elididas (os prejuizos categoriais) e os efeitos pragmáticos das estruturas emergentes dessas alterações (Lima-Hernandes 2006).
Sincronia, diacronia e sintemática. Contribuições para uma teorização do estudo dos sintemas
Authors: MARÇALO Maria João
Published: February 2023

Para uma descrição da sintemática, interessam-nos à partida, de modo provisório, todos os grupos linguísticos formados por combinação fixa de dois ou mais monemas. Defendemos que um trabalho sobre sintemas, mais do que um estudo dos usos registados, deverá ser um estudo das potencialidades do sistema linguístico particular constituído pela sintemática. A sincronia dinâmica é a perspectiva adequada para urna observação, descrição e explicação dos processos sintemáticos do português contemporâneo. Uma descrição da sintemática do português terá consequentemente de ser uina descrição da sincronia dinâmica.
Estudios de lexicografía regional: primeros registros de voces vascongadas en diccionarios del español
Authors: MORENO MORENO María Águeda
Published: February 2023

El objetivo principal del trabajo es la localización de voces vascongadas en la producción lexicográfica española de los siglos XVI-XVII, y para ello nos hemos valido de aquellos primeros datos y hemos obtenido como resultado un léxico marcado y circunscrito geográficamente a esta región en tres diccionarios monolingües del español, los tres grandes repertorios léxicos, de naturaleza etimológica, previos al corpus académico. La técnica de marcación diatópica dentro del artículo lexicográfico se presenta a modo de enunciados especiales, informaciones, si acaso, de tipo secundario, pero no por ello de menor interés. No en vano, con este tipo de información se sustenta toda la investigación que aquí se presenta. Los trabajos de selección de léxico histórico regional en diccionarios claramente nos facilitan ver cómo ha sido el proceso de marcación diatópica en nuestra tradición lexicográfica. Dichos trabajos se fundamentan, especialmente, en los diccionarios académicos o en aquellas obras que se reconocen como hitos en la tradición. Asimismo, se hace uso del soporte informático en orden al método sistemático y especifico de marcación y representación, mediante el sistema arbóreo de exhibición de información de los materiales.
Józef Barnn: Humanismo y poesía
Authors: BENITEZ BURRACO Antonio , SOBIESKA Anna
Published: February 2023

Tildada tradicionalmente de apolítica, la poesía de Józef Baran representa, no obstante, un lúcido, sentido y coherente intento por defender la dignidad del ser humano a través de la literatura. Nacida de la compasión por el sufrimiento del otro, la poesía de Baran supone una vindicación permanente del valor de la vida y de la importancia de que revisten los pequeños placeres que ésta nos ofrece, llegando en último término a plantearse el sentido de la existencia y el valor que para el hombre posee lo trascendente. La Poética de Baran se halla en consonancia con los presupuestos éticos que defiende a través de sus versos: con su estilo sencillo, directo, tenido de lirismo y de una amable ironía; esta poesía busca ante todo entablar un diálogo con el lector, a quien invita a discutir las grandes cuestiones filosóficas que el poeta ha querido plantear en su obra.
Evolución de los estudios de Lenguaje y Género: valoración crítica en torno al método empírico y los condicionantes socioculturales
Authors: CARRANZA Aurelia , RIVAS María del Mar
Published: February 2023

El estudio del lenguaje de la mujer a partir de datos más o menos empíricos no es algo nuevo. Con el paso del tiempo ha evolucionado no sólo la forma en que dichos estudios se llevan a cabo, sino también la interpretación que tiene lugar a partir de los datos obtenidos. En este trabajo pretendemos hacer un repaso de los estudios más relevantes que se han hecho en los últimos años y analizar la evolución que ha sufrido la situación de la mujer en la sociedad de forma paralela a los mismos. Mantenemos que estos dos fenómenos están íntimamente relacionados.
Eloisa to Abelard de Alexander Pope
Authors: GARCÍA CALDERÓN Ángeles
Published: February 2023

Trabajo que se ocupa del poema de Alexander Pope consagrado a los dos famosos amantes de principios del siglo XIII: tras llevar a cabo una breve revisión de la correspondencia de Abelardo y Eloísa, se analiza estilísticamente la epístola del poeta inglés, poniendo de relieve las similitudes entre el estado anímico de los personajes y el del escritor en el momento de la redacción de su obra.
Paradoxe et inversion chez Baltasar Gracián: la figure duale de Démocrite et Héraclite
Authors: VILA BAUDRY Berénice
Published: February 2023

Estudio de la figura dual de Demócrito y Heráclito en la obra de Baltasar Gracián y, en particular, en El Criticón. La utilización. por parte de Gracián de la pareja formada por el filósofo que ríe y el filósofo que llora hace de la figura a la vez una figura de estilo y una figura de pensamiento. Encarnación de la paradoja, la figura de Demócrito y Heráclito define una dinámica de ida y vuelta incesante, característica fundamental de la escritura del jesuita, entre dos actitudes extremas y opuestas - la risa y el llanto -. Al estilo del alterutrum definido en El Criticón como una cifra del mundo, la figura de los filósofos es un instrumento de análisis y de comprehensión del universo de Gracián.
La expresión del dolor en la lírica medieval alemana: Kreuzlied, Fraueizlied, Tagelied
Authors: BALBUENA TOREZANO María del Carmen
Published: February 2023

El presente trabajo aborda la expresión del duelo en la lírica alemana de La Edad Media, tomando como modelos tres subgéneros líricos, todos ellos pertenecientes al denominado Minnesang, o poemas-canciones que expresan el amor cortés. Para ello, se tendrán en cuenta los presupuestos del denominado código caballeresco, así como el papel femenino y el masculino presentes en los poemas.
Antecedentes e interferencias en la decoración del manuscrito vat. supl. grec 911 de la Biblioteca Vaticana
Authors: MARCOS ALDÓN Manuel
Published: February 2023

El presente trabajo tiene como fin demostrar la interrelación existente entre las escuelas miniaturísticas occidentales merovingias y las orientales, tanto las de origen italiano como las palestinas y siriacas. Estas relaciones prueban que la visión tradicional de la circulación cultural en el mundo del libro es mucho más amplia y de gran alcance entre las dos Europas.
Una ciudad fotografiada: comparando imagen cotidiana e imagen turística en Fortaleza (Brasil) a partir de Instagram
Authors: Paul i Agusti Daniel , Dos Santos Costa Madson
Published: February 2023

El análisis de las representaciones, eso es, de la subjetividad con la que las personas muestran un espacio, aporta una información muy valiosa para conocer los distintos vínculos que los individuos establecen con su entorno. Ahora bien, cada grupo tiende a aportar una imagen distinta. El presente artículo se centra en analizar coincidencias y divergencias en las representaciones espaciales de las imágenes cotidianas y las de los turistas. Para ello se analizan las imágenes colgadas en Instagram por habitantes y turistas de la ciudad de Fortaleza (Brasil). Los resultados muestran, en líneas generales, divergencias entre los espacios y los usos representados por ambos colectivos lo que permite mostrar cómo una ciudad tiende a cristalizar en situaciones, producciones o figuras particulares referenciadas a las actividades cotidianas o turísticas que allí transcurre. Un aspecto que puede ayudar a gestionar una ciudad adaptada a habitantes y turistas.
The development of PROS- 'Protocolising Referrals Ophthalmology Sifts'
Authors: Tiew Stephenie , Osman Lina , Tank Vivek , Sentance Zack , Bocock Tom , De Silva Ian
Published: February 2023

A combination of high demand and post COVID-19 backlogs of follow-up patients has had a significant impact in accommodating new ophthalmology referrals in one of the busiest departments for outpatient activity. The Protocolising Referrals Ophthalmology Sifts (PROS) study aims to identify how existing pathways can be better utilised, establish new pathways based on demand and provide a framework for developing a local referral guideline for community optometrists, general practitioners, and other hospital healthcare professionals. This prospective study analysed 1,000 consecutive general new patient referrals to a busy tertiary ophthalmology department at University Hospitals of Leicester. All referrals were checked for duplication and triaged by the project group clinicians based on local criteria for available patient pathways. Outcomes included discharge without further intervention, assessment in an alternative non ophthalmologist led clinic or a face to face consultant led clinic. Majority of referrals were by community optometrists (83%), followed by general practitioners (8%). Almost a quarter of patients (23%) could be discharged without further consultation. Approximately 40% of patients could be seen in an alternative non consultant clinic such as an optometry led clinic, ophthalmic imaging technician led clinic, combined orthoptics and optometry clinics, nurse led clinics, or a telephone/video service. The remaining 38% required a face to face consultant led clinic consultation. The study identified a further 6% of patients could be seen in an ophthalmic imaging technician led choroidal naevi clinic pathway, which was subsequently introduced. A set of referral and triage guidelines were established to provide feedback to referrers and ensure that patients were seen in the right place in the correct setting by the most appropriate healthcare professional. As far as we are aware, this is the first study in England showing real world data of ophthalmology referrals from community or primary care to secondary care. Findings have led to transformation work in how secondary eye care can be delivered.
Do we know enough about the effect of low-dose computed tomography screening for lung cancer on mortality to act? An updated systematic review, meta-analysis and network meta-analysis of randomised controlled trials 2017 to 2021.
Authors: Duer Emma , Yang Huiqin , Robinson Sophie , Grigore Bogdan , Sandercock Josie , Snowsill Tristan , Griffin Ed , Peters Jaime , Hyde Chris
Published: February 2023

Background
Diagnosis of lung cancer frequently occurs in its later stages. Low-dose computed tomography (LDCT) could detect lung cancer early.
Methods
Our objective was to estimate the effect of LDCT lung cancer screening on mortality in high risk populations.
A systematic review of randomised controlled trials (RCTs) comparing LDCT screening programmes with usual care (no screening) or other imaging screening programme (such as chest X-ray (CXR)) was conducted. RCTs of CXR screening were additionally included in the network meta-analyses. Bibliographic sources including MEDLINE, Embase, Web of Science and the Cochrane Library were searched to January 2017, and then further extended to November 2021. All key review steps were done by two persons. Quality assessment used the Cochrane Risk of Bias tool. Meta-analyses were performed.
Results
Nine RCTs, with up to 12.3 years of follow-up from randomisation, were included in the direct meta-analysis, which showed that LDCT screening was associated with a statistically significant decrease in lung cancer mortality (pooled relative risk (RR) 0.87, 95% confidence interval [CI] 0.77 to 0.96). There was a statistically non-significant decrease in all-cause mortality (pooled RR 0.98, 95% CI 0.95 to 1.01). The statistical heterogeneity for both outcomes was minimal. Network meta-analysis including the nine RCTs in the direct meta-analysis plus two further RCTs comparing CXR with usual care confirmed the size of the effect of LDCT on lung cancer mortality and that this was very similar irrespective of whether the comparator was usual care or CXR screening.
Conclusions
LDCT screening is effective in reducing lung cancer mortality in high risk populations. The uncertainty of its effect on lung cancer mortality observed in 2018 has been much reduced with new trial results and updates to existing trials, emphasising the importance of up-dating systematic reviews. Although there are still a number of RCTs unreported or in progress, we predict that further evolution of summary mortality estimates is unlikely. The focus for debate now moves to resolving uncertainty about the cost-effectiveness of LDCT screening taking into account the balance between benefits and harms which occur in all screening programmes.
Two-layer computation offloading strategy under collaborative D2D-assisted MEC system
Authors: Xu Fei , Ning Linpeng
Published: February 2023

Under the intelligent inspection scenario, the intelligent inspection robot will generate a large amount of real-time sensing data in the process of autonomous inspection ,which needs to be processed immediately. The limited battery life and computing capacity of the intelligent inspection terminal will cause problems such as long fault location time and slow response for incident handling. Due to the hardware conditions at the network’s edge, it is difficult for the traditional MEC system to ensure that the inspection data are processed in real-time when the inspection terminals are dense. Therefore, the article considers combining the D2D (Device-to-Device) communication technology with the MEC system to further improve the computing capability of the cellular network through collaborative processing between intelligent inspection terminals. The following problem is that each inspection terminal can choose too many offloading nodes. In this paper, we consider both cellular and multiplexed communication modes. We hace studied the collaborative task offloading problem that minimizes the weighted sum of robot device energy consumption and task delay in the MEC-D2D scenario with the constraints of task deadline and the channel interference of cellular communication users. To solve this problem, we construct a new general graph with weights to D2D link assignment based on the quantized computation and communication models. Based on this, we propose a solution based on graph matching. We also model the optimization problem in this paper as a terminal channel game problem, analyze the structural properties of the game, and prove the existence of a Nash equilibrium for the game. We design a two-layer distributed channel game algorithm to solve the above problem and quantitatively compare its performance metrics with respect to the centralized optimal solution and the single-layer offloading strategy. The numerical results confirm that the proposed algorithm achieves excellent computational offloading performance and good scalability as user size increases.
Cardiometabolic, Functional, and Psychosocial Effects of a Remotely Supervised Home- based Exercise Program in Individuals with Type 2 Diabetes (RED Study): A Randomized Clinical Trial
Authors: Rodrigues Samara Nickel , Delevatti Rodrigo Sudatti , Carvalho Mauricio Tatsch Ximenes , Alberton Cristine Lima
Published: February 2023

Background: Type 2 diabetes mellitus (T2D) is a serious global health problem, and exercise is considered an essential non-pharmacological tool in T2D prevention and treatment. During periods of social isolation experienced by the COVID-19 pandemic, home-based exercise programs were strongly recommended as a strategy to facilitate exercise practice and reduce the negative impacts of social isolation. Remotely supervised exercise stands out as an easily accessible strategy after the pandemic, as it is a tool that aims to facilitate access to exercise by this population. The purpose of the RED study is to verify the effects of a remotely supervised home-based exercise program compared to a control group on cardiometabolic, functional, and psychosocial outcomes in patients with T2D.
Methods: Participants are randomized into the control group (CG) and the intervention group (IG). The CG receives recommendations for the physical activity practice, while the IG will perform a 12-week home-based exercise program supervised remotely by video call. The participants’ cardiometabolic, functional, and psychosocial parameters are assessed at baseline (week 0) and post-intervention (week 13).
Discussion: It is expected that the results of the proposed study will benefit the knowledge base of health professionals and provide more evidence for a growing area, i.e., home-based exercise and T2D. Additionally, the expectation is to verify and demonstrate whether this program can be accessible and effective for different health outcomes in patients with T2D.
Trial Registration: The RED study protocol was prospectively registered at ClinicalTrials.gov (NCT05362071). Date registered April 6, 2022.
Complete chloroplast genomes of six Neotropical palm tree species: genome structure comparison, identification of repeats sequences and evolutionary dynamic patterns
Authors: Francisconi Ana Flávia , Marroquín Jonathan Andre Morales , Cauz-Santos Luiz Augusto , Berg Cássio van den , Martins Kaunne Karolina , Costa Marcones Ferreira , Picanço-Rodrigues Doriane , de Alencar Luciano Delmodes , Zanello Cesar Augusto , Colombo Carlos Augusto , Hernández Brenda Gabriela Díaz , Amaral Danilo Trabuco , Lopes Maria Teresa Gomes , Veasey Elizabeth Ann , Zucchi Maria Imaculada
Published: February 2023

The Arecaceae family has a worldwide distribution, specially in the tropical and subtropical regions. We sequenced the chloroplast genome of Acrocomia intumescens and A. totai, widely used in the food and energy industry, Bactris gasipaes, important for palm heart, Copernicia alba and C. prunifera, worldwide known for wax utilization, and Syagrus romanzoffiana, of great ornamental potential. Copernicia spp. showed the largest chloroplast genomes (C. prunifera: 157,323 bp and C. alba: 157,192 bp), while B. gasipaes presented the smallest (155,078 bp). Copernicia spp. had two more gene copies (trnL-GAG) than the others, and S. romanzoffianaunderwent pseudogenization in one copy of rps19. Structurally, great synteny was detected among palms. Conservation was also observed in the distribution of single sequence repeats (SSR). Copernicia spp. presented less dispersed repeats, without occurrence in the small single copy (SSC). All RNA editing sites were C (cytidine) to U (uridine) conversions. Overall, closer phylogenetically species shared more sites. Almost all nodes of the phylogenetic analysis showed posterior probability (PP) of 1.0, reaffirming the close relationship between Acrocomia species. These results elucidate the conservation among palm chloroplast genomes but point to subtle structural changes, providing support for the evolutionary dynamics of the Arecaceae family.
Effects of Floating Macrophytes on Evaporation Rates in Tropical Reservoirs
Authors: Rodrigues Italo Sampaio , Costa Carlos Alexandre Gomes , Teixeira Adunias dos Santos , Neto Iran Eduardo Lima , Lopes Fernando Bezerra Lopes , de Araújo José Carlos
Published: February 2023

Reservoir evaporation represents one of the most significant forms of water loss in tropical and semi-arid areas, but methods to accurately quantify evaporation fluxes at large scales are currently missing. The objectives of this study were: (1) to estimate evaporation in two Brazilian tropical reservoirs by calibrating the Stephens-Stewart equation through remote sensing, and (2) to assess the relationship between macrophyte coverage and evaporation. The calibrated Stephens-Stewart equation provided similar results to class A pan reference measurements (root mean square error of 0.8 mm/day). The two reservoirs yielded an evaporation volume that would be sufficient to meet the water needs of almost a million people. Furthermore, due to the poor water quality of one of the reservoirs, an important percentage of its surface area was covered by macrophytes. Macrophyte coverage was negatively correlated with the evaporation flux (R²=0.76), and led on average to an 11% reduction of the estimated evaporation rate. Overall, the results of this study demonstrate the usefulness of using remote sensing products to estimate reservoir evaporation and outline the need to better understand the relationship between macrophyte cover and reservoir evaporation in tropical and semi-arid areas.
Combined β-Sitosterol and Trimetazidine mitigate potassium dichromate-induced cardiotoxicity in rats through the interplay between NF-κB/AMPK/mTOR/TLR4 and HO-1/NADPH signaling pathways
Authors: El-Shoura Ehab A.M. , Salem Maha , Ahmed Yasmine H. , Ahmed Lamiaa Khalaf , Zaafar Dalia
Published: February 2023

Hexavalent chromium salt, like potassium dichromate (PD), is chromium's most precarious valence state, present in industrial wastes. Recently, there has been increasing interest in β-sitosterol (BSS), a bioactive phytosterol, as a dietary supplement. BSS is recommended in treating cardiovascular disorders due to its antioxidant effect. Trimetazidine (TMZ) was used traditiovally for cardioprotection. Through the administration of BSS and TMZ, the cardiotoxic effects of PD were to be countered in this study, in addition to examining the precise mechanism of PD-induced cardiotoxicity. Thirty male albino rats were divided into five groups; the control group: administered normal saline daily (3 mL/kg); the PD group: administered normal saline daily (3 mL/kg); BSS group: administered BSS daily (20 mg/kg); TMZ group: administered TMZ daily (15 mg/kg). BSS+TMZ group: administered both BSS (20 mg/kg) and TMZ (15 mg/kg) daily. All experimental groups, except the control, received on the 19th day a single dose of PD (30 mg/kg/day, SC). Normal saline, BSS, and TMZ were received daily for 21 consecutive days orally. The exposure to PD promoted different oxidative stress, proinflammatory, and cardiotoxicity biomarkers. BSS or TMZ succeeded solely in reducing this deleterious effect; however, their combination notably returns measured biomarkers close to normal values. The histopathological investigations have supported the biochemical findings. The combination of BSS and TMZ protects against PD cardiotoxicity in rats by reducing oxidative stress and apoptotic and inflammatory biomarkers. It may be promising for alleviating and treating PD-induced cardiotoxicity in people at an early stage.
Risk prediction and interaction analysis using polygenic risk score of type 2 diabetes in a Korean population
Authors: Song Minsun , Kwak Soo Heon , Kim Jihyun
Published: February 2023

Joint modelling of genetic and environmental risk factors can provide important information to predict the risk of type 2 diabetes (T2D). Therefore, to predict the genetic risk of T2D, we constructed a polygenic risk score (PRS) using genotype data of one Korean cohort, KARE (745 cases and 2549 controls), and the genome-wide association study summary statistics of Biobank Japan. We evaluated the performance of PRS in an independent Korean cohort, HEXA (5684 cases and 35703 controls). Individuals with T2D had a significantly higher mean PRS than controls (0.478 vs. -0.076, p ≈ 0). PRS predicted the risk of T2D with an AUC of 0.654 (95% CI: 0.646–0.662). We also evaluated interaction between PRS and waist circumference (WC) in the HEXA cohort. PRS exhibited a significant sub-multiplicative interaction with WC (ORinteraction= 0.992, 95% CI: 0.989–0.996, pinteraction=0.0001) in T2D. The effect of WC on T2D decreased as PRS increased. The sex-specific analyses produced similar interaction results, revealing a decreased WC effect on T2D as the PRS increased. In conclusion, the risk of WC for T2D may differ depending on PRS and those with a high PRS might develop T2D with a lower WC threshold. Our findings are expected to improve risk prediction for T2D and facilitate the identification of individuals at an increased risk of T2D.
Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer
Authors: Park Soonyoung , Jeong Kang Jin , Poire Alfonso , Zhang Dong , Tsang Yiu Huen , Blucher Aurora , Mills Gordon
Published: February 2023

Ferroptosis, a form of programed cell death, can be promoted by inhibitors of the xCT transporter (erastin) or GPX4 (RSL3). GPX4, but not the xCT transporter, is selectively elevated in luminal breast cancer. Consistent with this observation, the majority of luminal breast cancer cell lines are exquisitely sensitive to RSL3 with limited sensitivity to erastin. In RSL3 resistant, but not sensitive, luminal breast cancer cell lines, RSL3 induces HER2 pathway activation. Irreversible HER2 inhibitors including neratinib reversed RSL3 resistance in constitutively RSL3-resistant cell lines. Combination treatment with RSL3 and neratinib increases ferroptosis through mitochondrial iron-dependent reactive oxygen species production and lipid peroxidation. RSL3 also activated replication stress and concomitant S phase and G2/M blockade leading to sensitivity to targeting the DNA damage checkpoint. Together, our data supports exploration of RSL3 combined with irreversible HER2 inhibitors in clinical trials.
Cross-Modal Semantic Analysis by Tri-factorized Modular Hypergraph Autoencoder
Authors: Malik Shaily , Bansal Poonam , Jatana Nishtha , Dhand Geetika , Sheoran Kavita
Published: February 2023

The data from different sensors, cameras, and their text descriptions needs their features to be mapped into a common latent space with lower dimensions for image-to-text and text-to-image classifications. These low-dimensional features should incur maximum information with minimum losses. The cross-modal semantic autoencoder is proposed in this paper, which factorizes the features into a lower rank by nonnegative matrix factorization (NMF). The conventional NMF lacks to map the complete information into lower space due to two matrix factorization which is overcome by a novel tri-factor NMF with hypergraph regularization. A more information-rich modularity matrix is proposed in hypergraph regularization in place of the feature adjacency matrix. This tri-factorized hypergraph regularized multimodal autoencoder is tested on the Wiki dataset for the image-to-text and text-to-image conversion. This novel autoencoder is also supported by Multimodal Conditional Principal label space transformation (MCPLST) to reduce the dimension of the features. The proposed autoencoder observed a classification accuracy improvement of up to 1.8 % than the semantic autoencoder.
Power analysis of cell-type deconvolution methods across tissues
Authors: Pournara Anna Vathrakokoili , Miao Zhichao , Beker Ozgur , Brazma Alvis , Papatheodorou Irene
Published: February 2023

Cell-type deconvolution methods aim to infer cell-type composition and the cell abundances from bulk transcriptomic data. The proliferation of currently developed methods, coupled with the inconsistent results obtained in many cases, highlights the pressing need for guidance in the selection of appropriate methods. Previous proposed tests have primarily been focused on simulated data and have seen limited application to actual datasets. The growing accessibility of systematic single-cell RNA sequencing datasets, often accompanied by bulk RNA sequencing from related or matched samples, makes it possible to benchmark the existing deconvolution methods more objectively. Here, we propose a comprehensive assessment of 29 available deconvolution methods, leveraging single-cell RNA-sequencing data from different tissues. We offer a new comprehensive framework to evaluate deconvolution across a wide range of simulation scenarios and we show that single-cell regression-based deconvolution methods perform well but their performance is highly dependent on the reference selection and the tissue type. We validate deconvolution results on a gold standard bulk PBMC dataset with well known cell-type proportions and suggest a novel methodology for consensus prediction of cell-type proportions for cases when ground truth is not available. Our study also explores the significant impact of various batch effects on deconvolution, including those associated with sample, study, and technology, which have been previously overlooked. The evaluation of cell-type prediction methods is provided in a modularised pipeline for reproducibility (https://github.com/Functional-Genomics/CATD_snakemake). Lastly, we suggest that the Critical Assessment of Transcriptomic Deconvolution (CATD) pipeline can be employed for the efficient, simultaneous deconvolution of hundreds of real bulk samples, utilising various references. We envision it to be used for speeding up the evaluation of newly published methods in the future and for systematic deconvolution of real samples.
Particulate matter exposure increases the risk of reduction in human fecundity in South Asia
Authors: Wang Huailin , Zhu Zhenghong , Benmarhnia Tarik , Jalaludin Bin , Chen Xin , Wulayin Maimaitiminjiang , Huang Cunrui , Zhang Tuantuan , Xu Lianlian , Wang Qiong
Published: February 2023

The estimated infertility prevalence in South Asia was among the highest in the world, however, epidemiological study concerning the effects of particulate matter exposure was absent in this region. Utilizing the well-adopted Demographic and Health Survey data, 27,462 eligible women were included to estimate fecundity and its association with particulate matter exposure in South Asia. The couple’s fecundity, including time to pregnancy and infertility prevalence, was estimated to be from 5.53 to 11.57 months, and from 26–49%, respectively. An overall association of reduced fecundity with increased particulate matter exposure was identified, with adjusted fertility time ratios (95% confidence intervals) being 1.05 (1.04, 1.06), 1.04 (1.03, 1.05), and 1.01 (1.01, 1.02) per 10 µg/m3 increment in PM1, PM2.5, and PM10, respectively. Furthermore, millions of months’ delay in achieving pregnancy might be attributed to particulate matter exposure. Here, our findings suggest that human fecundity is threatened by ambient particulate matter in South Asia.