bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of the WBSI Questionnaire in a Study Group of Patients With Polytrauma During the Period 2015-2021
Authors: Anghele Mihaela , Marina Virginia , Moscu Cosmina Alina , Romila Aurelia , Dragomir Liliana , Anghele Aurelian-Dumitrache , Lescai Alina-Maria
Published: October 2023

The present study started from empathy towards the patient and the fact that medicine is always looking for optimal solutions for the patient's well-being. The state of health, however, is not limited to the physical body, but the psychological mental status, the environment, the recovery time must be taken into account. The medical act is not limited to the life-saving gesture applied at a given moment.  Polytrauma requires prompt and safe medical gestures, but the patient does not recover from this tragic episode in the near future. Time, patience, attention, coping mechanisms, psychological wellbeing, and a conducive environment are needed to compete with the previous medical act in order to recover fully and as quickly as possible.  The length of hospitalization means financial costs, but the full recovery of the patient, the mental well-being, translates into hidden costs, borne by both the patient and the health system.
Based on these ideas, the present study tried to add value to health care. Considering polytrauma as a possible trigger for PTSD, considering recovery as closely related to coping mechanisms, the study aimed to find the linking element in this "polytrauma-recovery" pathway. Why is recovery easier in some cases? Why does the number of hospital days vary in the context of similar physical injuries? Why do cases of higher severity recover more easily than others with lower severity scores?
This study set out to explain how trauma and its psychological implications (rumination, nightmares, anxiety, obsessive thoughts about the injury) may be blamed for a more difficult recovery.
The Psychodrama Method of Group Psychotherapy
Authors: Pylypenko Nataliia , Radchuk Halyna , Shevchenko Viktoriia , Horetska Olena , Serdiuk Nataliia , Savytska Olha
Published: October 2023

The article presents a theoretical-methodological analysis of the psychodrama method of group psychotherapy. It examines the aim, objectives, advantages, peculiarities and structure of classical psychodrama as a method of group psychotherapy. Also, the article attempts to define psychodrama as a group psychotherapy process. It studies the links between psychodrama and methods of various psychological approaches. Importantly, the article suggests a phenomenological approach to studying the interaction among the participants in psychodramatic psychotherapy groups to develop effective technologies for implementing psychodramatic techniques. It justifies the methodological and methodical essence of psychodramatic technologies in group psychotherapy, its main characteristics and goals. From the perspective of an integrative approach, psychodramatic technologies in group psychotherapy ensure the interrelation and interdependence of its psychodiagnostic and psychodevelopmental components. Meanwhile, the article considers the organizational, methodical and structural-dynamic features of using the interactive and role-playing method in group psychotherapy depending on the type of psychodrama. It shows how one can practically apply the “mirroring” psychotechnique in combination with the fairy tale metaphor (the method of enacting a fairy tale) in all types of psychodrama, along with an analysis of the advantages of its use and resourcefulness. Finally, the article discusses a methodical combination of psychodrama and transactional analysis within the “psychodramatic triangle” technique. It provides methodical recommendations for emotional disorder correction using the psychodrama method. The relevant indicators of the effectiveness and efficiency of the psychodrama method in group psychotherapy include catharsis, insight, expressions of trust and a sense of comfort in the space of group interaction and feedback, as an existing objective reality.
The Neuropedagogical Aspects of Mental and Cognitive Activity in Younger School-Age Children
Authors: Bakhmat Nataliia , Dzhyhun Liudmyla , Mishchenko Maryna , Polishchuk Olena , Savytska Olha , Dorofey Svitlana
Published: October 2023

This article discusses theoretical angles of investigating the psychological development of younger school-age children and the examination of cognitive processes, due to the fact that each age group is associated with its own predominant activity. The leading activity is distinguished by the formation and alteration of other forms of activity, the restructuring of fundamental cognitive processes and personality development. It might not consume all of a child’s spare time, but it does affect his/her growth during that age. Engaging in learning activities is of paramount importance for young learners. Firstly, it establishes essential relationships between the child and society. Secondly, it serves as the groundwork for developing core personality traits and certain cognitive processes of younger school-age children. The level of success that students in this group attain will significantly determine their well-being and standing in the class. Ukrainian research has outlined various learning challenges commonly experienced by younger school-age children and the psychological factors behind them. Accordingly, learning challenges can be attributed to a lack of attention, inadequate short-term and long-term memory, visual reasoning, mental processes and general intelligence. However, not only children with learning difficulties require an individual approach. Considering the distinct cognitive mental processes of younger school-age children, teachers can create the most favourable conditions for their learning and growth. Therefore, this article aims to study the characteristics of cognitive mental processes in younger school-age children.
How does Information Manipulation Interfere with Normal Brain Function? The Disruption of Neuroethics in War-Time Mass Media
Authors: Hotsur Oksana , Danylina Olena , Zozulia Nataliia , Stiekolshchykova Valentyna , Porpulit Olena , Danko-Sliptsova Anna
Published: October 2023

The article describes massive changes in the brain function of mass-media recipients. It is written within the relevant neuro social state of the Ukrainian mass media society in the conditions of undeclared military censorship and counter-propaganda. The material for analysis was two groups of data: content analysis of news media and a sociological survey of citizens for the presence of cognitive dissonance and lies that can violate neuroethics, namely, forming a distorted picture of the world, creating long-term deprivation and inadequate neural connections.
The purpose of such research was to find out the regular influence of affective and defamatory infospace on the brains of people whose countries are at war. We clarified the nature of the newest manipulations in the media and around ethical issues, the state of research on the neuroethics of manipulations, comparing the nature of war journalistic manipulations in Russian and Ukrainian media and the objectification and explanation of neuroethical violations in Ukrainian media through the techniques of lying, silencing, avoidance, analysis, self-counting, etc.
The authors used methods of theoretical, statistical, comparative and systemic analysis, content analysis, sociological methods of collecting background data and neuro interpretive methods for the received input data.
The result of the article was a systematization of the manipulation of the brain in a state of permanent tension; in particular, we identified ways of institutional avoidance or deception and diagnosis of specific neuroethical threats and consequences among the population (emotional dependency, deprivation, emotional-cognitive dissonance, lack of entitlement to accurate truth, the difference between the content of the national and local media, etc.)
Ignition of Small Molecule Inhibitors in Friedreich's Ataxia with Explainable Artificial Intelligence
Authors: Kırboğa Kevser Kübra , Küçüksille Ecir Uğur , Köse Utku
Published: October 2023

Iron (Fe) chelating medicines and Histone deacetylase (HDAC) inhibitors are two therapy options for hereditary Friedreich's Ataxia that have been shown to improve clinical results (FA). Fe chelation molecules can minimize the quantity of stored Fe, and HDAC inhibitors can boost the expression of the Frataxin (FXN) gene in enhancing FA. A complete quantitative structure-activity relationship (QSAR) search of inhibitors from the ChEMBL database is reported in this paper, which includes 437 compounds for Fe chelation and 1,354 compounds for HDAC inhibitors. For further investigation, the IC50 was chosen as the unit of bioactivity, and following data refinement, a final dataset of 436 and 1,163 compounds for Fe chelation and HDAC inhibition, respectively, was produced. The Random Forest (RF) technique was used to generate models (train R2 score, 0.701 and 0.892; test R2 score 0.572 and 0.460, for Fe and HDAC, respectively). The models created using the PubChem fingerprint were the strongest of the 12 fingerprint kinds; hence that feature was chosen for interpretation. The results showed the importance of properties related to nitrogen-containing functional groups (SHAP value of PubchemFP656 is -0.29) and aromatic rings (SHAP value of PubchemFP12 is -0.16). As a result, we explained the effect of the molecular fingerprints on the models and the impact on possible drugs that can be developed for FA with artificial intelligence (XAI), which can be explained through SHAP (Shapley Additive Explanations) values. Model scripts and fingerprinting methods are also available at https://github.com/tissueandcells/XAI.
Major Trends in Today's Intelligent Robotics in Light of the Creation of Collaborative Artificial Intelligence
Authors: Ienina Iryna , Ovcharenko Oleksii , Opuschko Nadiia , Chumak Mykola , Zahorodnia Tetiana , Dorofieiev Oleksandr
Published: October 2023

Robotics and advances in artificial intelligence are breakthrough innovations with considerable promise and the potential to radically change the economic and social aspects of society. Research on the development of robotics is still scarce. This article fills the gap by analyzing the creation and diffusion of robotics innovation and the role of intellectual property in this process. The robotics innovation ecosystem is based on cooperative networks of independent specialists, scientific organizations, and companies. The state plays a significant role in supporting the innovation activity in the considered sphere, first of all, through grant financing, placement of defense orders and implementation of national strategies of robotics development. Competitions and prizes are an important incentive for creating innovations. Patenting is used by companies to protect intellectual property from encroachment by third parties, to ensure freedom of action, to license technology, and to protect against prosecution. The industrial revolution has changed the very notion of means and means of production in the minds of the masses in such a way that the process of robotization and the introduction of artificial intelligence in different areas of life has become inevitable. The article presents an analysis of possible ways of disclosing the concept of "artificial intelligence" as a legal category and its correlation with the concept of "robot", considers the issues of legal responsibility for the performance of work by artificial intelligence, studies the possibility of recognizing the holder of artificial intelligence work as a subject of law.
Psycho-Motor Skills in Swimming Among Children: Gender Differences
Authors: Petrea Renato Gabriel , Moraru Cristina Elena , Rusu Oana Mihaela , Rus Cristian Mihail , Fagaras Pia Simona , Cristea Florentina
Published: October 2023

Psychomotricity is a broad term that encompasses different approaches to bodily action to support children and adolescents to reach their highest motor and cognitive potential. The aim of the study was to highlight gender differences in the manifestation of psychomotor behaviors in 8–9-year-old children who practice sports swimming. The subjects (N=52, 26 males, 26 females) are children aged 8.0-9.11 years (M = 8.80; SD = ±0.65) who practice swimming in one of the swimming pools of a city in Romania. They were tested, using specific instruments, to assess the level of manual dexterity, body schema, hand laterality, body balance, body balance on water/buoyancy, general coordination. For four of the variables (manual dexterity, body schema, hand laterality and spatial orientation) no statistically significant differences were found, while for the other three (body balance, body balance on water and general coordination) statistically significant differences were recorded. The results indicate differences between the two genders, girls in this age group who practice swimming having more developed psychomotor skills compared to boys.
Determining Views on the Efectivity of Augmented Reality Applications in Museums
Authors: Islek Didem , Bicen Huseyin
Published: October 2023

In recent years, visitor-centred approaches have been adopted in museums, which are seen as some of the most important cultural establishments in forming modern culture. Therefore, it is aimed to increase visitor interest towards the collections and to portray the information about the collections more clearly. Digital technology is used to make collections exhibited in museums more interactive and augmented reality applications are used for this. The aim of this study is to determine the views of students on using augmented reality in museums. The research was conducted with the mixed method. The data in the quantitative dimension were collected with a student view questionnaire and the qualitative data were collected using a semi-structured interview form. The findings indicate that students believe they can learn information more permanently if augmented reality is used in museums and that the simpler the technology is, the easier it will be to learn how to use it. According to the results of this research, students stated that they can have more realistic experiences in museums that use augmented reality technology and that they can feel as if they are viewing the exhibitions in a more realistic setting. Students also believed that the historical animation of the exhibitions will result in more motivating and rich content. Additionally, they believe that the augmented reality applications and set up used in museums would positively affect learning.
Innovative Trends in Educational Management in a Globalized World: Organizational Neuroscience
Authors: Sas Nataliia , Mosiakova Irina , Zharovska Olena , Bilyk Oleh , Drozd Tetiana , Shlikhtenko Lidiia
Published: October 2023

The article discusses the problems and prospects of personally centric and, partly, technological reforms in the management of Ukrainian educational institutions in the context of innovation and leading global trends.
The main idea of the article is to deploy the concept that institutionalized education is self-regulated by local actors and relies on the human proactive motivated resource of teachers and students with minimal implementation from above.
The purpose of the article was to investigate three aspects of education management: innovative global trends, problems of current education management in Ukraine and recommendations and methodological advice for such management.
The authors used mainly theoretical methods of literature selection by keywords, system analysis of this literature, methods of summarizing - generalizing - classifying principles, methods and forms of education management, as well as the method of design and educational modeling to provide specific recommendations and advice.
The result of the article was a synthesis of the latest global trends in educational management, which we summarized in 12 key points; argumentation of challenges and obstacles to innovative management of educational institutions in Ukraine, identification of destructive factors in the way of this management and provision of outline recommendations for reform.
Using Artificial Intelligence in Education
Authors: Shuliar Vasyl , Shkurko Valentyna , Polukhtovych Tetiana , Semeniako Yuliia , Shanaieva-Tsymbal Liudmyla , Кoltok Lesіa
Published: October 2023

The article discusses e-learning tools as a fundamental step in implementing digital learning technologies as a factor in the development of teachers’ creativity today. Recently, higher education has been developing with the help of digital technologies that significantly enhance education quality. The integration of complex software-hardware systems into the educational process lies in incorporating big data analytics, robotics, neural networks and artificial intelligence. The objectives of reforming the educational system require corresponding changes in teaching methods, as well as in higher education, through informatization and digitalization. This has led to the emergence of open education which allows for unrestricted access to educational resources. Open education also contributes to the development of digital pedagogy. Indeed, every student can choose an optimal educational programme to follow a personalized learning trajectory online which considers one’s characteristics and interests. After all, the development of digital pedagogy requires addressing various organizational, methodical and practical issues. They range from implementing digital learning technologies in the context of open education and culminating in the creation of a long-term strategic plan that will gradually transform the educational process and, in turn, encourage teachers to think creatively.
The Challenges and Opportunities of Interdisciplinary Perspectives in Nonprofit Management Education
Authors: Bezboruah Karabi
Published: October 2023

The complex nature of social issues makes interdisciplinary perspectives an important aspect of current research and education. Nonprofit management education posits itself as a ground for interdisciplinary perspectives as they train future nonprofit leaders who would be at the center of the solution for some of these social issues. While nonprofit management education can gain many benefits from interdisciplinary perspectives, the challenges must be considered and recognized. This paper covers some of the opportunities and challenges of interdisciplinary perspectives in nonprofit management education. The paper concludes with some implications and questions about the practicality of interdisciplinary education.
Teaching About Nonprofits in American Legal Education
Authors: Sidel Mark
Published: October 2023

This article discusses the various ways in which nonprofits are taught in American legal education, indicating the focus on nonprofit law and management as well as on experiential education and focus on tax issues. It also discusses teaching materials used and the possibilities for going beyond the single course model in teaching nonprofit in American legal education.
Access to Financial Information for Tax Purposes and Proportionality – Balancing Public Interest with the Protection of Privacy
Authors: Teixeira Glória , Pinho Maria Filipa , Teixeira Hugo
Published: October 2023

The purpose of the article is to analyse how to balance public interests with the protection of privacy in the tax field. It has not been an easy task especially in the context of access to financial information.

In this area, the compromise to achieve transparency needs to pay regard to the principle of proportionality, as reinforced by recent case law of the ECJ, and align with specific legislation such as the EU General Data Protection Regulation and recently enacted EU Digital Services Act.

It is extremely important to investigate the possible consequences of acting against fundamental rights that are attributed to European citizens (and not only), such as the right to privacy and the protection of personal data. The paper aims to provide relevant and further insight to paths that lead to a fair way to handle such relevant information.

Every citizen, every academically inclined and dedicated individual, every public official, every judicial agent, must question whether the public interest can ever, or at least, recurrently, surpass a fundamental right to privacy, specially, in a sensible area as the financial information of an individual. Such actions can often lead, if mistakes are made along the way, to dangerous outcomes, such as public humiliation, and can even harm the person’s professional and personal life.

Methodology. In the course of the paper, an analysis is made of public decisions taken in cases across the European continent. Additionally, some considerations are made about the recent legislation that is produced by competent authorities, particularly the European Institutions.

Results of the research. The authors offer a personal insight regarding the information that has been gathered, confirming some significant concerns. What is of crucial importance, as stated in the title of this article, is a well established balance between the public interest and the protection of privacy, with explained and defined possible paths to follow.
Percepción del sexismo benevolente en jóvenes frente a casos de violencia de pareja contra la mujer
Authors:   , Corrales Aparicio Paula Michell , Schroder Sanchez Moreno Alessandra
Published: October 2023

La siguiente investigación aborda un tema relevante en nuestra sociedad. El incremento de casos de violencia de pareja contra la mujer se ha visto en aumento, dado que una de las causas son las actitudes sexistas benevolentes que tienen los varones y que a su vez son percibidas y normalizadas por otros varones. Asimismo, el presente estudio tiene como objetivo conocer la percepción del sexismo benevolente en jóvenes frente a casos de violencia de pareja contra la mujer. Se desarrolló un estudio de tipo cualitativo y se adoptó el diseño de análisis temático con la participación de 11 jóvenes varones, cuyas edades varían entre 21 a 25 años y quienes se encuentran en una relación de pareja. Se les aplicó una entrevista semiestructurada. Los principales resultados muestran que el poder y dominio percibido por los hombres es una de las causas de la violencia de pareja contra la mujer, la cual se da a través del sexismo benevolente. Este en varias ocasiones puede ser visto en el cuidado hacia la mujer, en los estereotipos que diferencian al hombre de la mujer y de igual modo, ser la mujer vista como un objeto y una fuente de reproducción. Se concluye que el sexismo benevolente puede explicar el mantenimiento y la justificación de la violencia contra la mujer en una relación de pareja y que los participantes perciben el sexismo benevolente a partir de sus propias experiencias y la de otros hombres.
Maternidad en estudiantes universitarias de Lima Metropolitana
Authors:   , Busquets Zuleta Luana Mariel
Published: October 2023

El objetivo de la investigación es describir la experiencia de maternidad en mujeres que tuvieron un hijo durante sus estudios universitarios. Se desarrolló un estudio cualitativo de diseño fenomenológico, aplicándose la técnica de la entrevista semiestructurada a una muestra de diez mujeres de entre los 32 y 54 años de edad que se convirtieron en madre durante sus estudios superiores y que culminaron la universidad. Los principales resultados indican que desde el embarazo surgen transformaciones, corporales y psicológicas que permiten adaptarse al rol de madre. Además, las participantes optaron establecer su propia forma de crianza a partir de las vivencias de su propia historia y consolidaron una red de apoyo para compatibilizar el rol de madre con el de estudiante. Así, se concluye que la maternidad involucra procesos de adaptación y reorganización psíquica y social para cumplir con las demandas del rol materno y de universitaria.
Proceso de aculturación en migrantes venezolanos residentes en Lima Metropolitana
Authors:   , Almendrades Farfan Diana Maribel
Published: October 2023

Esta investigación tiene como objetivo explorar el proceso de aculturación en migrantes venezolanos de 25 a 35 años residentes en Lima Metropolitana. El diseño utilizado es fenomenológico con un valor teórico, social y metodológico. Los resultados muestran que las estrategias más utilizadas son la asimilación e integración, las cuales significan mayores recursos intrínsecos, más altos niveles de bienestar y mejores relaciones con los otros. La motivación principal para salir de su país es encontrar mejores oportunidades laborales y económicas. Sus relaciones interpersonales pasan a un segundo plano porque priorizan el trabajo. Según los entrevistados, lo más difícil, son los prejuicios percibidos y la discriminación. La satisfacción actual se determina de manera variable, según la experiencia de cada individuo. Dentro de las limitaciones, está la edad de los participantes, el lugar de residencia actual y las escasas investigaciones sobre el auge migratorio de la población venezolana.
AKUNTABILITAS PENGELOLAAN ALOKASI DANA DESA DALAM UPAYA MENINGKATKAN PEMBANGUNAN DAN PEMBERDAYAAN MASYARAKAT DI DESA BATUBINTANG KECAMATAN BATUMARMAR KABUPATEN PAMEKASAN 2021
Authors: Moh Yasin Abd Hakim , M. Bashri Asy’ari
Published: October 2023

Alokasi Dana Desa (ADD) sebagai bantuan stimulan atau dana perangsang untuk mendorong dalam membiayai program penyelenggaraan pemerintahan desa, pelaksanaan pembagunan, pembinaan kemasyarakatan, dan pemberdayaan masyarakat. Penelitian  ini bertujuan   untuk   menganalisis penerapan akuntabilitas Alokasi Dana Desa  (ADD) dalam uapaya meningkatkan pembangunan dan pemberdayaan masyarakat di Desa Batubintang Kecamatan Batumarmar Kabupaten Pamekasan.Penelitian ini menggunakan pendekatan kualitatif  deskriptif yakni data yang dikumpulkan dalam bentuk data yang berupa kata-kata, gambar,dan bukan angka-angka, memanfaatkan metode ilmiah dan menggunakan pendekatan esklpor lapangan, data yang dibutuhkan dengan cara observasi, wawancara, dokumentasi dan lain-lain. Hasil penelitian ini adalah 1. Penerapan akuntabilitas pengelolaan Alokasi Dana Desa (ADD) di Desa Batubintang Kecamatan Batumarmar Kabupaten Pamekasan. a. Trasparansi. Transparansi yang dimaksud adalah keterbukaan aparatur desa terhadap masyarakat dalam penerapan ADD. b. Akuntabel. Akuntabel yang dimaksud adalah perencanaan, pelaksaan dan evalusi dalam penerapan ADD. c. Pertisipatif. Partisipstif yang di maksud adalah dalam penerpan ADD masyarakat juga ikut andil dalam perencanaan sampai evaluasi berdasarkan MusDes. 2. Penerpan akuntabilitas pengelolaan alokasi Dana Desa (ADD) dalam uapaya meningkatkan pembangunan dan pemberdayaan masyarakat di Desa Batubintang Kecamatan Batumarmar Kabupaten Pamekasan. a. Infrastruktur. Infrastruktur yang dimaksud adalah pembangunan jalan, perbaikan balai dan pembuatan selokan. b. Penangulangan posko Covid-19. Penanggulangan posko Covid-19 yang dimaksud untuk mempermudah intraksi masyarakat dengan petugas terkait penanggulangan Covid-19.
Responsibility as the Spirit of Zakat Accounting Practices: Islamic Ethnomethodology Study
Authors: Thalib Mohamad Anwar
Published: October 2023

This study aims to reveal the local cultural values of zakat fitra accounting practices. This research uses the Islamic paradigm. The approach used is Islamic ethnomethodology. There are five data analysis stages: charity, knowledge, faith, revelation information, and courtesy. The results of the study indicate that there is a value of responsibility behind the accounting practice of distributing zakat fitra. This value is reflected through the actions of the amil zakat, who use data from the government, data and advice from residents about citizens who are entitled to receive zakat fitra, amil zakat coordinators who distribute zakat not only to less fortunate citizens but amil officers who are by the Shari'a Islam. As well as the decision of the amil to distribute zakat funds three days before Eid al-Fitr. It is intended that zakat recipients can use these funds to meet their needs. In the Islamic culture of Gorontalo, the value of responsibility is often advised through the expression (lumadu) "eya dila pito-pito'o" meaning God does not close his eyes. This phrase means that whatever we do, Allah is always watching.
Institutos Federais: entre o excesso de passado e a incerteza do futuro
Authors: Oliveira Tiago Fávero
Published: October 2023

This work analyzes the creation policy of the Federal Institutes, fifteen years after its implementation, with regard to its institutional identity. The study focuses on reflection on the identity of Federal Institutes (IFs): multi-campus institutions, marked by the diversity of courses, modalities and levels of education, as well as with different histories and social contexts. For this, the article focuses its atention on the analysis of the object from the historicity category: it seeks to understand how professional education was conceived in Brazil over time and the impacts that these visions and disputes had on the identity of the Federal Institutes. From this debate, it is inferred for the future prospects of the institution, in the face of the challenges that are currently placed. By way of conclusion, the study recognizes the potential of the policy under analysis with regard to the offer of emancipatory education, without failing to point out the dilemmas, challenges, contradictions and threats that the Federal Network needs to face.
The Effect of Chitosan and Polyvinyl Alcohol Combination on Physical Characteristics and Mechanical Properties of Chitosan-PVA-Aloe vera Film
Authors: Zatalini Dioni fadia , Hendradi Esti , Philip Drake  , Sari Retno
Published: October 2023

Background: Wound is a condition where there is damage or disruption to the anatomical structure and function of the skin. Wounds that are not treated properly can lead to infection. As wound dressings, film dressings have many advantages such as being elastic, flexible, transparent, and can adapt to the wound shape. Film’s characteristics of are affected by the plasticizer and the polymer. Combination of chitosan and polyvinyl alcohol (PVA)  is able to improve the mechanical properties of the film such as its swelling capacity, tensile strength, and elongation at break. Objective: This study aims to determine the effects of chitosan and PVA in various concentrations on the physical characteristics and mechanical properties of the film. Methods: Film was prepared by solvent casting method, using chitosan and alginate in various concentrations of 0% to 1.5%, 1.5% Aloe vera, and 6% propylene glycol. Films’ characteristics and mechanical properties were evaluated, such as swelling index, tensile strength, elongation at break, and Young’s modulus. Results: The result showed that chitosan and PVA polymers had a significant effect on the swelling index, tensile strength, elongation at break, and Young’s modulus. The effect of chitosan and PVA combination on the swelling index, tensile strength, and elongation at break is due to the hydrogen bonding between the hydroxyl group of PVA and the amine group of chitosan. Conclusion: The combination of chitosan and polyvinyl alcohol influenced the film's physical and mechanical properties. Film with chitosan and polyvinyl alcohol ratio of 1.5%:1.5% have best characteristics compared to others.
Risk Factor Analysis of Adverse Effects of Kanamycin and Capreomycin on Kidney Function in Multidrug-Resistant TB Patients
Authors: Bambang Subakti Zulkarnain  , Syefi Nuraeni Fitriana  , Herri Yulimanida
Published: October 2023

Background: Multidrug-Resistant TB treatment's high side effects and long duration are barriers to successful TB therapy. Various side effects such as age, gender, body weight, comorbidities, and drug dose can cause severe side effects, including impaired renal function (nephrotoxic). Objectives: This study aimed to analyze the risk factors of side effects of the failure of kanamycin and capreomycin therapy that can cause impaired renal function in Multidrug-Resistant TB patients. Methods: Data were collected retrospectively by searching and recording the medical records of Multidrug-Resistant TB patients at the Multidrug-Resistant TB Polyclinic. There were 183 patients at Dr Soetomo Hospital who met the inclusion criteria. Results: There was a significant relationship between gender in the kanamycin group and the appearance of side effects of renal impairment (p= 0.035). There was no effect of age, comorbid diseases, body weight, and dose of drug administration on the side effects of kanamycin and capreomycin in treating Multidrug-Resistant TB on impaired renal function (nephrotoxic). However, nephrotoxic side effects in elderly patients were more common in the kanamycin group (p=0.001). Conclusion: Gender affects the side effects of kanamycin and capreomycin in treating Multidrug-Resistant TB in nephrotoxic patients.  In addition, stricter supervision of the use of kanamycin in elderly patients (>40 years) to minimize the incidence of side effects of impaired renal function in the treatment of Multidrug-Resistant TB.
Perception of Hospital Pharmacist on Working Performance in Yogyakarta Province, Indonesia
Authors: Muin Dona , Satibi Satibi , Ari Kristina Susi , Suryo Prabandari Yayi
Published: October 2023

Background: Pharmacists support the success of hospital in efforts to improve people's quality of life then the performance measurement of pharmacists is carried out. Objectives: This study aimed to measure pharmacist performance based on the perception of pharmacists working in hospitals. Methods: Perception surveys were conducted with pharmacists working in public hospitals. The assessment was performed using a closed questionnaire that was proven to be valid and reliable. This study evaluated pharmacists’ perceptions of their work performance and their ability to perform their roles, duties, and functions in the hospital. A total of 192 pharmacist respondents answered 61 statements in the questionnaire that were divided into 11 dimensions as follows:1) the objectives set; 2) following the procedure; 3) initiatives; 4) performing the main task; 5) the ability to cooperate; 6) out implementing pharmaceutical standards; 7) the potential for solving problems; 8) quick response; 9) self-competence; 10) the ability to take verbal orders and writing; and 11)  endurance at work. Results: The various answers of respondents to the questionnaire led to the conclusion that pharmacists' performance in hospitals is included in the high-performance category. Conclusion: This study showed that pharmacists have a high perception of their ability to work, as outlined in their assessment of their work performance in hospitals. Pharmacists' perceptions of their workplace performance in public hospitals are useful for developing pharmaceutical services. The results of this study are expected to provide a basis for improving the performance of pharmacists working in hospitals, especially hospitals in the Yogyakarta area.
Fabrication Methods of the Polygonal Masonry of Large Tightly-fitted Stone Blocks with Curved Surface Interfaces in Megalithic Structures of Peru
Authors: Lapshin Rostislav
Published: October 2023

The article suggests methods that allow creating the most complicated type of polygonal masonry found in Peru. This masonry type consists of large stone blocks weighing from several hundred kilograms to several tons fitted close to each other almost without a gap between complicated curved surfaces over a large area. The work provides a description of techniques, which apparently were used by builders who arrived from Europe. The techniques under discussion are based on the use of a reduced clay model, 3D-pantograph, topography translator and replicas. The use of the topography translator, reduced clay model and pantograph provides not only the unique appearance and high quality of masonry of large blocks, but also allows to increase the productivity of the builders significantly. As machines coping-scaling three-dimensional objects are known since the beginning of the 18th century, the stone structures under consideration should be approximately dated by this time. The remaining simpler types of polygonal masonry, when the stones are small or the fitted surfaces are almost flat, or the stones contact each other over a small area, or there are significant gaps between the stones, are quite consistent with the well-known methods of stone processing at that time or earlier, and, therefore, they do not require any additional explanations. The Fortress Sacsayhuaman is considered as an example of early star fortresses that has survived to our time. The polygonal structures in Peru, the polygonal Face Towers and polygonal bas-reliefs in Cambodia, symmetrical statues of pharaohs in Egypt are based on the same construction technologies, working methods, tools and technical contrivances. Therefore, with a high probability one can state that all these monuments were created by the same group of architects, sculptors, builders, and could not have appeared before the 17th century.
Self-Interactions, Self-Energy and the Electromagnetic Contribution to the Anomalous g-Factor
Authors: Georgiev Miroslav
Published: October 2023

The present paper reports an exact approach quantifying the electromagnetic contribution to the anomalous magnetic moment occurring in isolated system comprised of non-composite particle carrying elementary electric charge. Essential averaging procedure and regularization of the electromagnetic field potentials necessary when quantifying the electromagnetic self-interactions and when deriving equations of motion without singularities and obeying the conservation laws are thoroughly discussed. The study shows that the dynamics of the considered system is associated to a unique classical transcendental equations of motion satisfied by the particle’s velocity and the electromagnetic contribution to the anomalous g-factor known from the quantum electrodynamics. The equations of motion predict a value of the anomalous g-factor that agrees with the experimentally measured one reported in the literature and that calculated with the aid of quantum electrodynamics. In the present study the computational accuracy is restricted to match one part in a billion, obtaining ae=0.001159652(23), thus reveling the potential of non-perturbative methods in predicting the electron’s anomalous g-factor.
Sex-specific Impact of 17β-estradiol and Testosterone Levels on Inflammation and Injury in Acute Myocardial Infarction
Authors: Semerdzhieva Niya Emilova , Tsakova Adelina Dimitrova , Hristova Julieta , Lozanov Valentin Stoychev , Loznova Vesela Valentinova , Gospodinova Mariana , Dimitrov Simeon Ivanov , Atanasov Petar Yordanov , Chaneva Maria
Published: October 2023

Estrogens play a protective role during early life stages. However, endogenous 17β-estradiol (E2) can accelerate atherosclerosis progression in low-grade inflammatory conditions like established atherosclerosis. Our single-center cohort study assessed sex-specific associations of gonadal hormones with oxidative stress, inflammation, and myocardial injury markers in 111 patients (37% women) diagnosed with acute myocardial infarction (MI) between July 2011 and December 2013. Blood samples were collected within 48 hours of symptom onset, and we measured sex steroids (E2, total testosterone [T]), oxidized low-density lipoproteins, high-sensitive C-reactive protein (CRP), white blood cell counts (WBC), and cardiac enzymes (creatine kinase [CK], the CK Muscle-Brain fraction [CK-MB], and high-sensitive troponin T [hsTnT]). The SYNTAX score gauged coronary disease severity from coronary angiography results. In men with acute MI, peak cardiac enzyme levels were predicted by post-percutaneous coronary intervention (PCI) E2 plasma levels (OR 1.011, p=0.047 - CK; OR 1.018, p=0.013 - CK- MB; OR 1.019, p=0.005 - TnT), peak WBC count (OR 1.487, p=0.015 - CK ; OR 1,709, p=0,005 - CK- MB; OR 1.391, p=0.012 - TnT), and peak CRP plasma levels (OR 1.040, p=0.033 - CK; OR 1.024, p=0.029 - CK-MB; OR 1.063, p=0.006 - TnT). T levels and E2/T ratio were associated with post-PCI CRP in these men (OR 0.980, p = 0.024 - T, OR 1.010, p = 0.076 - CRP). For women, peak WBC was a marker of highest testosterone (OR 1.348, p = 0.062), and only WBC was a significant indicator of myocardial injury extent (OR 1.426, p=0.039 - CK; OR 1.384, p=0.036 - CK-MB; OR 1.299, p=0.048 - TnT). During acute MI, elevated endogenous estradiol levels correlate with myocardial necrosis severity in men, while in women, increased leukocyte levels indicate acute myocardial damage. Elevated plasma T is associated with increased WBC in women. In men, post-PCI plasma CRP specifically indicates endogenous T levels and E2/T ratio during the acute phase.
Image quality and quantitative PET parameters of low-dose [18F]FDG PET in a Total-Body PET/CT scanner.
Authors: Calderón Eduardo , Schmidt Fabian P. , Lan Wenhong , Castaneda-Vega Salvador , Brendlin Andreas S. , Trautwein Nils F. , Dittmann Helmut , La Fougère Christian , Kiefer Lena Sophie
Published: October 2023

Total-body PET/CT scanners provide increased sensitivity, enabling the adjustment of imaging parameters by reducing injected activity or shortening acquisition time. This study aimed to evaluate the limitations of reduced [18F]FDG activity doses on image quality, lesion detectabil-ity, and quantification of lesion uptake in the Biograph Vision Quadra, as well as to assess the benefits of the recently introduced ultra-high sensitivity mode in a clinical setting. A number of 26 patients who underwent [18F]FDG-PET/CT (3.0 MBq/kg, 5 min. scan time) were included in this analysis. PET raw data was rebinned for shorter frame durations to simulate 5 min. scans with lower activities in high sensitivity (HS) and ultra-high sensitivity (UHS) modes. Image quality, noise, and lesion detectability (n=82) were assessed using a 5-point Likert scale. The co-efficient of variation (CoV), signal-to-noise ratio (SNR), tumor-to-background ratio (TBR), and standardized uptake values (SUV) including SUVmean, SUVmax, and SUVpeak were evaluated. Sub-jective image ratings were generally superior in UHS compared to HS mode. At 0.5 MBq/kg, le-sion detectability decreased to 95% (HS) and 98% (UHS). SNR was comparable at 1.0 MBq/kg in HS (5.7±0.6) and 0.5 MBq/kg in UHS (5.5±0.5). With lower doses, there were negligible reductions in SUVmean and SUVpeak, whereas SUVmax increased steadily. Reducing [18F]FDG activity to 1.0 MBq/kg (HS/UHS) in a total-body PET/CT provides diagnostic image quality without statistical-ly significant changes in uptake parameters. UHS mode improves image quality, noise, and le-sion detectability compared to HS mode.
Luminescence of ZrO2: Ti Ceramics Irradiated with High-Energy Xenon Ions
Authors: Dauletbekova Alma , Zvonarev Sergey , Nikiforov Sergey , Akilbekov Abdirash , Shtang Tatiana , Karavannova Natalia , Akylbekova Aiman , Ishchenko Alexey , Akhmetova-Abdik Gulzhanat , Baimukhanov Zein , Aralbayeva Gulnara , Baubekova Guldar , Popov Anatoli I
Published: October 2023

Samples of ZrO2 ceramics with different concentrations of impurity titanium ions were synthesized by mixing powders of zirconium and titanium oxides in various mass ratios. The phase composition and surface morphology of the studied ceramics were determined by X-ray phase analysis and scanning electron microscopy. It was found that irradiation of samples with xenon ions (220 MeV) with fluences 1010 and 1012 ion/cm2 leads to a decrease in the intensity of the pulse cathodoluminescence band at 2.5 eV. It is shown that ion irradiation causes the appearance of a new peak of thermoluminescence at 450-650 K of a non-elementary form associated with radiation-induced traps of charge carriers. In contrast to electron irradiation, an increase in the fluence of ions leads to a decrease in the intensity of this peak. In contrast to electron irradiation, an increase in the fluence of ions leads to a decrease in the intensity of this peak. A complex nonmonotonic dependence of the cathode and thermoluminescence intensity on the dopant concentration was found, which may be due to the effects of concentration quenching and aggregation of defective centers.
Investigation of the Combined Influence of Temperature and Humidity on Fatigue Crack Growth Rate in Al6082 Alloy in a Coastal Environment
Authors: Alqahtani Ibrahim , Starr Andrew , Khan Muhammad
Published: October 2023

The fatigue crack growth rate (FCGR) of aluminium alloys under the combined influence of temperature and humidity remains a relatively unexplored area, receiving limited attention due to its intricate nature and challenges in predicting the combined impact of these factors. The challenge was to investigate and address the specific mechanisms and interactions between temperature and humidity, as in coastal environment conditions, on the FCGR of aluminium alloy. The present study conducts a comprehensive investigation on the combined influence of temperature and humidity on the FCGR of Al6082 alloy. The fatigue pre-cracked compact tension specimens were corroded for 7 days and then subjected to various temperature and humidity conditions in a thermal chamber for 3 days to simulate coastal environments. The obtained data were analysed to determine the influence of temperature and humidity on the FCGR of Al6082 alloy. An empirical model was also established to predict fatigue life cycle values under these environmental conditions precisely. The correlation between FCGR and fracture toughness models was also examined. The Al6082 alloy exhibits a 34% increase in the Paris constant C, indicating reduced FCGR resistance due to elevated temperature and humidity levels. At the same time, fatigue, corrosion, moisture-assisted crack propagation, and hydrogen embrittlement lead to a 27% decrease in threshold fracture toughness. The developed model exhibited accurate predictions for fatigue life cycles, and the correlation between fracture toughness and FCGR showed less than 10% error, indicating a strong relationship between these parameters.
Pathogenetic Insights in Developmental Coordination Disorder Reveal Substantial Overlap with Movement Disorders
Authors: Garofalo Martinica , Vansenne Fleur , Sival Deborah A. , Verbeek Dineke S.
Published: October 2023

Developmental Coordination Disorder (DCD) is a neurodevelopmental condition characterized by non-progressive central motor impairments. Mild movement disorder features have been observed in DCD. Until now, the etiology of DCD remains unclear. Recent studies suggested a genetic substrate in some patients with DCD, but comprehensive knowledge about associated genes and underlying pathogenetic mechanisms is still lacking. In this study, we first identified genes described in literature in patients with a diagnosis of DCD according to the official diagnostic criteria. Second, we exposed the underlying pathogenetic mechanisms of DCD, by investigating tissue- and temporal gene expression patterns and brain-specific biological mech-anisms. Third, we explored putative shared pathogenetic mechanisms between DCD and frequent movement disorders with a known genetic component, including ataxia, chorea, dystonia, and myoclonus. We identified 12 genes associated with DCD in literature, which are ubiquitously expressed in the central nervous system throughout brain development. These genes are involved in cellular processes, neural signaling and nervous system development. There was a remarkable overlap (62%) in pathogenetic mechanisms between DCD-associated genes and genes linked with movement disorders. Our findings suggest that some patients might have a genetic etiology of DCD, which could be considered part of a pathogenetic movement disorder spectrum.