bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of physical training in cardiac rehabilitation in patients with congestive heart failure and type 2 diabetes mellitus
Authors: Sinkova M. N. , Isakov L. K. , Plotnikova E. Yu. , Barbarash O. L.
Published: November 2024

Introduction. Currently, the effectiveness of cardiac rehabilitation of patients with comorbid CHF using physical training when prescribing optimal drug therapy, including SGLT2 drugs, has not been studied.

Aims. To study the effect of controlled physical training on the quality of life and prognosis of patients with CHF comorbid with type 2 diabetes mellitus against the background of rational pharmacotherapy.

Materials and methods. The study included 74 patients with CHF against the background of type 2 diabetes mellitus, receiving optimal drug therapy, with mandatory intake of SGLT2 drugs. Two groups were formed using the simple randomization method: “Physical training” (n = 35) – basic drug therapy supplemented by a program of controlled physical training and “Standard drug therapy” (n = 37) – only basic drug therapy. Patients in the standard drug therapy group were recommended regular aerobic physical activity of moderate intensity for 30–60 minutes at least 5 days a week.

Results. In the Physical Training group, after 12 months, an increase in the distance according to the results of the 6-minute walk test by 39.6% (on average 407.2 meters) was registered, in the Standard Drug Therapy group, physical tolerance increased by 12.2% (324.5 meters) (p = 0.002). According MLHFQ questionnaire in patients with CHF, the results were obtained that characterize the high social adaptation of patients during physical training in comparison with standard pathogenetic drug therapy. Thus, the MLHFQ indicator in the Physical Training group changed by an average of 25.2 points, and in the Standard Drug Therapy group – by 5.7 points, amounting to 37.3 ± 5.9 in the Physical Training group, and 58.2 ± 2.1 in the Standard Drug Therapy group (p = 0.001).

Conclusions. Physical training in patients with CHF associated with type 2 diabetes mellitus against the background of optimal drug therapy leads to an increase in the distance according to the results of the 6-minute walk test and contributes to an improvement in the quality of life.
Coagulation hemostasis disorders and elevated lipoprotein (a) levels in patients with arterial hypertension and multifocal atherosclerosis
Authors: Vedenskaya S. S. , Smolenskaya O. G. , Beltyukov E. K. , Grachev V. G. , Klyachina E. S. , Kovaleva A. D.
Published: November 2024

Introduction. Hemostatic disorders may act as additional risk factors in patients with arterial hypertension (AH) and multifocal atherosclerotic lesion (MFAL). Elevated lipoprotein (a) (Lp(a)) levels may exacerbate procoagulant shifts.

Aim. To identify disorders in the coagulation link of hemostasis in patients with AH and MFAL, depending on the level of Lp(a).

Materials and methods. The study included 219 patients with hypertension and MFAL, median age 59 (53; 66) years, of which 110 patients with stage I–II controlled hypertension (group 1) and 109 patients with stage III controlled hypertension with a history of ischemic stroke. Depending on the level of Lp(a), patients in each group were divided into 2 subgroups with Lp(a) levels < 50 mg/dl and with Lp(a) levels above 50 mg/dl. Patients of both groups received antihypertensive, lipid-lowering, antiplatelet therapy and had comparable values of blood pressure and lipid spectrum.

Results. In group 2 patients, procoagulant shifts were significantly more often recorded, despite the constant use of antiplatelet therapy. Violations of hemostasis parameters depending on the level of Lp(a) were observed in subgroups 1b and 2b. According to the results of multiple a posteriori comparisons, the most significant hypercoagulation changes were observed in patients with stroke, as well as with Lp(a) levels > 50 mg/dl.

Conclusions. Thus, in some patients with hypertension and MFAL, despite taking antihypertensive, lipid-lowering and antiplatelet therapy, coagulation hemostasis disorders may occur. Elevated Lp(a) levels are combined with more pronounced hemostatic disorders, especially in the presence of a previous stroke. Intensification of antithrombotic therapy may be considered in such patients to prevent cardiovascular complications.
Regional and ethnic factors of obesity and diabetes mellitus in women of re-productive age in the Pribaikal region
Authors: Egorova T. V. , Kireeva V. V. , Khamnueva L. Yu.
Published: November 2024

Introduction. Overweight is currently one of the leading global medical problems. Overweight and obesity contribute significantly to the development of diseases such as diabetes, cardiovascular disorder and can also cause premature death. Obesity has a negative impact on reproductive function; almost a quarter of women of childbearing age are overweight and about a third of them are obese.

Aim. To study the characteristics of carbohydrate metabolism, hormonal indicators, and clinical-metabolic profiles, as well as to assess the potential risk of developing diabetes mellitus in women of fertile age with overweight and obesity residing in the Baikal region.

Materials and methods. The study involved 60 overweight and obese women of reproductive age in the Pribaikalye region, including 33 women of Russian nationality (group 1) and 27 women of Buryat nationality (group 2). Anthropo-metric, sociodemographic and behavioural criteria were analysed, as well as questionnaires using the FINDRISC Scale. General clinical analyses of blood and urine were performed, lipid profile parameters, glucose, insulin, creatinine, transaminases, estradiol, thyroid hormone, leptin levels in blood plasma were studied. In addition, an oral glucose tolerance test was performed and the insulin resistance index (HOMA-IR) was calculated.

Results. In the group of Buryat women with lower body weight as compared to Russians, higher levels of leptin, HOMA- IR index, and larger waist circumference are observed. In Buryat women, low physical activity makes a significant contribution to the development of overweight and obesity, while for Russian women, excessive caloric intake is more important. In accordance with the results of the FINDRISC scale survey, the greatest contribution to the potential development of diabetes mellitus in the Russian group is body mass index (weight), and in the Buryat group, in addition to these indicators, waist circumference and reduced physical activity.

Conclusions. The results of the study will be of great help in the development of pro-grammes for the prevention of diabetes and obesity, taking into account regional and ethnic differences among the population.
Glucosuria as a major mechanism-associated effect of sodium-glucose cotransporter 2 inhibitors: Is there cause for concern?
Authors: Demidova T. Yu. , Izmaylova M. Ya.
Published: November 2024

Introduction. One of the main mechanisms of action of SGLT2 inhibitors is an increase in renal excretion of glucose and sodium, development of glucosuria against the background of decreased levels of daily glycemia. The frequency of glucosuria development in patients without DM/prediabetes, receiving SGLT2 inhibitors for the treatment of CHD or CKD, as a consequence of the mechanism of action of SGLT2 inhibitors inhibitors is poorly studied and seems to be very interesting.

Aim. To evaluate in real clinical practice the frequency of the development and severity of glucosuria in patients with CHF treated with inhibitors of SGLT2 inhibitors both on the background of concomitant DM2 and without type 2 DM.

Materials and methods. Within the framework of a one-stage, prospective, observational study we evaluated the frequency of development and severity of glucosuria in patients with CHF, receiving SGLT2 inhibitors inhibitors, who were in the cardiology department of V.P. Demikhov State Clinical Hospital of Moscow. A total of 230 patients were included in the analysis.

Results. The mean age of the patients was 74 [66; 83] years. Median LVEF was 36 [29; 44] %, NTproBNP 1019 [423; 2355] pg/ml. Heart failure with reduced ejection fraction (HFrEF) was recorded in 64.81% of patients, 17.13% had HF with mildly reduced ejection fraction and 18.06% had a СHF preserved ejection fraction. DM2 was present in 38.7 percent of patients with СHF.  Among patients with CHF, the ‘glucosuria phenomenon’ due to the administration of SGLT2 inhibitors was observed in 31.16% of those without DM2, and in 52.27% of СHF patients with concomitant DM2.

Conclusion. In patients with CHF receiving SGLT2 inhibitors therapy, the ‘glucosuria phenomenon’ developed in one in three patients without overt carbohydrate metabolism abnormalities and one in two with DM2. The findings suggest that the glucosuria effect of SGLT2 inhibitors is not a required event even in patients with DM2, which may influence the incidence of adverse events in general clinical practice. And the cardioprotective benefits of SGLT2 inhibitors may be due to other mechanisms unrelated to glucose excretion, which, according to recent studies, is considered a surrogate predictor of favorable prognosis concerning CHF and renal outcomes. Nevertheless, additional clinical and experimental studies are required to determine the cardioprotective mechanisms of SGLT2 inhibitors and the predictive value of drug-induced glucosuria.
The role and function of metformin in women’s reproductive health: From pre-pregnancy preparation to breastfeeding
Authors: Demidova T. Yu. , Teplova A. S. , Stepanova E. V.
Published: November 2024

Disorders of carbohydrate metabolism not only reduce the quality of life of patients of reproductive age due to violations of the regularity of menstruation, anovulation and other clinical manifestations, but also affect the stages of pregnancy planning, affect the course of pregnancy and play an important role in the postpartum period. In overweight women, the presence of insulin resistance (IR), as well as existing disorders of carbohydrate metabolism, a conscious approach to pregnancy planning with maintaining targets before and throughout pregnancy is extremely important. The particular importance of a responsible approach is necessary due to the fact that glycemic disorders in both hyperand hypoglycemia are associated with risks on the part of the patient and the unborn child. Infertility, miscarriage, the risk of preeclampsia and eclampsia, as well as a high risk of birth injury (in relation to both mother and child) due to the peculiarities of childbirth with a large fetus are common among patients with impaired carbohydrate metabolism. Among all disorders of carbohydrate metabolism in patients of reproductive age, the most common are such as prediabetes, gestational diabetes mellitus, type 2 diabetes mellitus, all of which are associated with IR. Polycystic ovary syndrome, one of the main pathogenetic links of which is also IR, can be outlined separately. The use of metformin as a drug aimed at reducing IR is pathogenetically justified in such situations, however, despite the evidence of the safety of metformin presented by a large number of studies, there are no unified recommendations on dosage, timing and duration of metformin administration.
The place of pasireotide in precision treatment of patients with acromegaly
Authors: Pronin E. V. , Alexeeva T. M. , Pronin V. S. , Antsiferov M. B.
Published: November 2024

Due to the syndromal nature of acromegaly, the effectiveness of its treatment depends on the consideration of age, clinical and pathomorphological features of the disease, which determine the logistics of the selection of personalized therapeutic measures. The disadvantage of the used empirical pharmacotherapy scheme with the help of the ‘trial and error’ method is the formal prescription of drugs without taking into account the peculiarities of the morphofunctional status of the supervised GH-secreting tumors and the targeting of drugs. The lack of differentiated approach to acromegaly treatment is accompanied by a high percentage of therapeutic failures, and also deliberately deprives a significant proportion of patients of the opportunity to achieve timely and safe control of the disease and improve the quality of life. The review presents a comparative analysis of modern drugs used in acromegaly with a focus on the clinical efficacy of the second-generation somatostatin receptor ligand – pasireotide. The mechanism of action and pharmacotherapeutic possibilities of pasireotide LAR are considered. The therapeutic niche for this drug is patients with the presence of sparsely granulated somatotrophic tumor (SGST), characterized by aggressive course, tendency to recurrence and refractoriness to therapy with first-generation somatostatin receptor ligands.Implementation of a precision approach using clinical, morphological, radiological and functional predictors allows not only to identify the specific morphotype of somatotrophic tumor, but also to predict the efficacy of the planned treatment. A table of multidirectional biomarkers of long-term sensitivity of tumor cells to first- and second-generation somatostatin receptor ligands is presented. When SGST, large size of the residual tumor and poor expression of the 2nd subtype of somatostatin receptors are detected, pasireotide LAR can be used as a 1st-line treatment, in both mono- and combination therapy with pegvisomant. Special caution is required when treating patients with diabetes mellitus or predisposition to its development. The paper discusses in detail the measures aimed at prevention, dynamic control and correction of pasireotide-associated hyperglycemia.
Satisfação e Lealdade em Foco:
Authors: Brandão Paulo Victor Tavares , Gonçalves Vieira Valéria
Published: November 2024

Este estudo investiga a aplicação do Net Promoter Score (NPS) para avaliar a satisfação e lealdade dos clientes em um restaurante de pequeno porte localizado na região central do município de Manaus, Amazonas. Um questionário, acessado via QR Code no restaurante, incluiu a métrica Net Promoter Score (NPS) e questões adicionais para captar o feedback dos clientes. Os dados foram tratados em duas etapas. Primeiro, as respostas do NPS foram classificadas em promotores, neutros e detratores, e o NPS foi calculado pela diferença entre promotores e detratores. Em seguida, as questões adicionais em escala Likert foram tabuladas no Excel, com percentuais de avaliação sobre comida, atendimento e ambiente. As respostas abertas foram analisadas qualitativamente para identificar motivos das notas atribuídas. Os resultados revelaram que 54,7% dos clientes são promotores, 30,9% neutros e 14,4% detratores, resultando em um NPS de 40,3%, classificando o restaurante na zona de aperfeiçoamento. Os promotores destacaram a qualidade da comida e o atendimento como principais fatores positivos, enquanto os detratores mencionaram a demora no serviço como aspecto negativo. Apesar de um bom número de promotores, o restaurante precisa focar em transformar os clientes neutros em promotores e reduzir o impacto dos detratores.
O uso de Controle Interno nas Micro e Pequenas Empresas do Polo Têxtil do Agreste Pernambucano
Authors: Serafim Alex , Silva Maria Aparecida Barra Nova da , Segundo Edson Reis Matias , Andrade Luzia Pessoa de , Batista Isaac Clementino
Published: November 2024

Sabe-se que o controle interno é uma ferramenta estratégica para as organizações, independente de porte ou ramo de atuação, uma vez que auxilia na tomada de decisão, contribuindo para a eficiência dos processos e continuidade do negócio. O presente artigo buscou demostrar o conhecimento e as percepções dos contadores acerca da utilização do Controle Interno nas micro e pequenas empresas do polo têxtil pernambucano. A pesquisa foi realizada com profissionais contábeis com registro ativo no CRC-PE que prestam serviços às micro e pequenas empresas da região que constitui Polo Têxtil Pernambucano. O estudo descritivo, adotou uma abordagem quantitativa, coletando os dados por meio de questionário estruturado e analisando-os por meio de estatística descritiva. Os resultados obtidos apontam dois aspectos relevantes: os contadores que atuam no universo da pesquisa possuem deficiências técnicas acerca do controle interno; e as empresas possuem limitações quanto ao uso do controle interno nos seus processos.
Wastewater biotreatment and bioaugmentation for remediation of contaminated sites at an oil recycling plant
Authors: Jemli Meryem , Karray Fatma , Mansour Lamjed , Loukil Slim , bouhdida Rihab , Yadav Krishna Kumar , Sayadi Sami
Published: November 2024

This work focused on the biotreatment of wastewater and contaminated soil in a used oil recycling plant located in Bizerte. A continuous stirred tank reactor (CSTR) and a trickling filter (TF) were used to treat stripped and collected wastewater, respectively. The CSTR was started up and stabilized for 90 days. Over the following 170 days, the operational organic loading rates of the TF and the CSTR were around 1,200 and 3,000 g chemical oxygen demand (COD) m−3 day−1, respectively. The treatment efficiency was 94% for total petroleum hydrocarbons (TPHs), 89.5% for COD, 83.34% for biological oxygen demand (BOD5), and 91.25% for phenol. Treated industrial wastewater from the TF was used for bioaugmentation (BA) of contaminated soil. The assessment of the soil took 24 weeks to complete. The effectiveness of the soil BA strategy was confirmed by monitoring phenolic compounds, aliphatic and polycyclic aromatic hydrocarbons, heavy metals, and germination index. The biodegradation rate of contaminants was improved and the time required for their removal was reduced. The soil bacterial communities were dominated by species of the genera Mycobacterium, Proteiniphilum, Nocardioides, Luteimicrobium, and Azospirillum, which were identified as hydrocarbon and phenol-degrading bacteria.
Português no Índico: evidências de nativização do português moçambicano
Authors: Silva Augusto Soares da , Mevis Alice
Published: November 2024

In the context of the growing pluricentricity of Portuguese, we analyze the nativization of African varieties of Portuguese within the Dynamic Model framework developed by Schneider (2007) for national varieties of English, with a particular focus on Mozambican Portuguese (MP). We start by providing key MP sociolinguistic data, such as the percentage of speakers of Portuguese (as either L1 or L2) and of the local Bantu languages, the social projection of Portuguese in Mozambique, the diglossic distribution and gradual language shift from Bantu languages towards Portuguese. Second, we analyze some of the main linguistic indicators of the nativization of MP: at the phonological level, with syllabic restructuring; at the syntactic level, with clitics, differential object marking, transitivization, double objects, and the emergence of new constructions such as the Recipient passive; and at the lexical level, with loanwords and neologisms. Finally, we discuss issues of language contact and degrees of influence from Bantu languages, stages in the stabilization of MP, and the restructuring of the European Portuguese grammar, leading to a dynamic and sociocognitive (re)interpretation of the nativization of MP.
A Grammatica Portugueza para uso da Escola Portugueza de Trangambar e o contraste entre línguas
Authors: Gonçalves Maria Filomena
Published: November 2024

In Trangambar (Tranquebar), on the coast of Coromandel (India), between 1725 and 1731, a Grammatica Portugueza came to light. Published in the Danish mission of that locality, this work has four parts, each focused to different aspects of the Portuguese language. Its author, Nikolaus Dal (1690-1747), was a German born in Denmark, who learned Portuguese in India, a language in which he wrote several works. The existence of a Portuguese school in Tranquebar, which was never a Portuguese possession, shows the importance of Portuguese language in that region, where it functioned as a "lingua franca", and justifies the printing of a grammar. The purpose of this study is to contextualize Dal's grammar in the so-called "missionary linguistics" and in Portuguese grammaticography. The following subjects exposed in the four parts of the grammar are examined, among others: the comparison of the pronunciation of Portuguese with other European languages and with the local language (Tamil), and some aspects of the lexicon.
Nomes a bordo: práticas de nomeação e variação regional das alcunhas em Portugal (1935-1975)
Authors: Silvestre João Paulo
Published: November 2024

The study examines the practice of assigning nicknames and their regional variation in Portugal, based on records from the Grémio dos Armadores de Navios da Pesca do Bacalhau, covering the period from 1935 to 1975. This archive, containing around 21,000 records, includes 4,200 nicknames, highlighting their relevance as identity markers. The study also analyses the evolution of legal norms that, initially restrictive, began to recognize the historical and identity value of nicknames, allowing their incorporation as surnames.
Constantes e variáveis: apontamentos sobre a construção de palavras em diferentes variedades do português
Authors: Pereira Rui
Published: November 2024

This article is structured around two concepts, constant and variable, which, being part of the specific lexicon of derivational morphology (Booij 2016; Jackendoff & Audring 2016), are operative in the analysis of variation that is attested in the domain of word construction in different varieties of Portuguese. In fact, as it has already been highlighted by several researchers (Mendes et al. 2016; Rio-Torto 2015; Soares da Silva 2010, 2018, 2022), the idiomatic space that we designate as “Portuguese” is covered by a set of continuities and discontinuities, which sometimes bring these varieties closer together and sometimes move them apart. If there is continuity in the word construction schemes that are used, the same does not happen when we compare the concrete instances of these schemes, due to the option for alternating constructional schemes or the use of specific lexical bases of a given variety, but not others. This situation can be observed, for example, in the construction of new words in the Mozambican variety of Portuguese.
Orientes - Aracne e a teia literária de Judith Teixeira (1880-1959)
Authors: Sousa Martim de Gouveia e
Published: November 2024

Considered by some to be the only woman in Portuguese modernism, Judith Teixeira manifests in her work, almost all written in the 1920s, an ethical exoticism and a red chromaticism (red is the most auspicious color in China) that make her writer, on this journey to the depths of self-knowledge, a case of literary brilliance and orientalist evasion. Now it is the mythological fable of Arachne that seems to apply to Judith Teixeira's journey: from poetic boldness to banishment, from near death to resurrection, it is fair that the Portuguese writer's asceticism incorporates an orientation that shows that the reasons and characteristics of difference orientalist forms a symbol of literary effectiveness and novelty. Finally, the aim is to fulfill the objective of unveiling the biobibliographical trajectory of a name that, despite the path taken, is important to expand and subject to new contributions and other readings.
The development of materials for teaching Portuguese in East Timor: an analysis of the manuals produced for the Anticorruption Committee (CAC)
Authors: Albino Susete
Published: November 2024

Between February 2020 and November 2021, the investigators and specialists of the Anticorruption Committee (CAC) of the Democratic Republic of East Timor benefited from intensive training in Portuguese language, with the aim of strengthening their linguistic proficiency, especially at a technical and legal level. This was carried out within the framework of the Delegated Cooperation Project PFMO - Osan Povo Nian, Gere Ho Di'Ak, funded by the European Union and co-financed and managed by Camões, Instituto da Cooperação e da Língua, I.P. The singularities and lack of resources for teaching Portuguese as L2 required the development of specific teaching materials that were appropriate to the context and that responded to the purpose of the courses designed. In this article I analyse the manuals created for levels A2 and B1, giving special relevance to the content produced based on the legal diplomas that govern the institution's activity in the field of preventing and fighting corruption and associated crimes.
Bridging Tridosha Siddhanta and Biorhythm Theory: Uniting Ancient Dosha Principles with Modern Cyclic Patterns
Authors: Yogita Yadav  , Ashok Bhagat  , Vinay Bhardwaj
Published: November 2024

This article explores the conceptual intersections between Tridosha Siddhanta, the foundational theory of Ayurveda, and the Biorhythm Theory, a modern psychological model of cyclical biological and emotional states. Tridosha Siddhanta posits that human health and wellness are governed by the balance of three fundamental Doshas Vata, Pitta, and Kapha each representing a combination of the five elements and their dynamic influences on physiological and psychological functions. In contrast, Biorhythm Theory suggests that individuals experience predictable cycles of physical, emotional, and intellectual states influenced by inherent rhythms. By analyzing both systems, this article seeks to elucidate how the cyclical nature of biorhythms might correlate with the doshic imbalances and fluctuations described in Ayurveda. It aims to provide a comprehensive understanding of how integrating these two paradigms can enhance approaches to personalized health and wellness, offering a holistic perspective that bridges ancient wisdom with contemporary scientific insights.
Scope of Ayurvedic Nasal Instillation Therapy (Nasya Karma) in Cosmetology: A Review
Authors: Sidhi Sharma  , Mamata Nakade  , Bhashanjali Singh
Published: November 2024

Cosmetics has become an important & influential part of human’s daily life in today’s world due to one’s tendency for self-care & regard as it boost their confidence and self-esteem. The increase in daily use of these various cosmetics has also garnered a lot of increased demand in pharmaceutical industry; resulting into various harmful & chemical drug practices for monetary gain also leading to lots of side effects of such cosmetics on human skin. The beauty ailments that commonly affect people are hair fall, greying of hairs, dandruff, acne, melasma, minor skin and oral disorders. These problems are not only difficult to treat but also requires a lot of expenses too. Ayurveda has mentioned various methods to tackle these problems as Ayurvedic scholars has put heavy weightage on importance of beauty; external as well as internal in both male and female and has described treatments for these ailments in ancient texts such as Nasya Karma [Ayurvedic Nasal Instillation Therapy]. Nasya is one of famous Panchakarma procedure used for management of above mention cosmetic ailments. It is a procedure in which herbal drug [oil/decoction/extract/powder] is instilled through nasal route and is highly appreciated for its therapeutic value in diseases related to Urdhava-Jatrugata [above clavicle region]. In this article, we have discussed various types and probable action of Nasya Karma [Ayurvedic Nasal Instillation Therapy] in these disorders and how this single Ayurvedic procedure can be a one stop solution for multiple beauty ailment and can be helpful in reaching the goal of enhancement of beauty with assurance of safety and prevention from any harmful effect.
Review of research works done on Rajata Bhasma [Incinerated Silver] at Institute of Teaching and Research in Ayurveda, Jamnagar
Authors: Kirtesh N Agey  , Poorvi P. Mahabdi  , Dilip Prajapati
Published: November 2024

Rajata a well-known metal known for its Medhya, Rasayana and Balya Karma. Rajata is cost effective compared to Swarna and possess similar properties to that of Swarna. Rajata Bhasma (RB) is a calcined silver compound widely used by practitioners of Ayurveda for various ailments like depletion of body elements, neurological disorders, muscular dystrophy, infertility, diabetes, various infectious conditions. Aim of the present study was to compile such available research works done on Rajata in the Department of Rasa Shastra and Bhaishajya Kalpana (RS and BK), ITRA, Jamnagar and provide brief information about pharmaceutical, analytical, and pharmacological studies. Total five studies on Rajata Bhasma, which revalidated the impact of classical guidelines, safety issues, and therapeutic utilities, were screened from Department of RS and BK, Institute for Teaching and Research in Ayurveda, Jamnagar. All studies revealed that Rajata Bhasma is safe clinically, experimentally at Therapeutic Equivalent Dose (TED) levels as no toxic hazards were reported during the treatment period. The clinical efficacy of Rajata Bhasma has been evaluated in Female infertility, Depression (Avasada) and memory enhancing activity. conditions. Satisfactory responses with a decrease in the intensity of signs and symptoms were reported in all the studies. Though certain limitations were observed in these researches, the results can be considered as a lead for further well stratified studies covering larger population. No adverse effects were reported in any of these studies.
Ekala Dravya Prayoga mentioned in classics for Ashmari Chikitsa - A Review
Authors: Sunona George  , M.S. Veena
Published: November 2024

Acharyas have described various disorders related to Mutravaha Srotas, with Ashmari being one such condition that can be correlated with urolithiasis based on its clinical features. It affects approximately 12 million people worldwide, with 1 in 10 individuals experiencing it at least once in their life-time, and 2% of cases being recurrent. Prevalence of renal calculi is more in males than in females about 11% in males and 9% in females. Though different treatment modalities are there for Ashmari, Ekala Dravya Prayogas are common, convenient, economical and effective method of treatment. Acharyas have described drugs such as Sigru (Moringa oleifera), Tumburu (Zanthoxylum alatum), Gokshura (Tribulus terrestris), Varuna (Crataeva nurvala) etc. for Ekamoolika Prayoga in Ashmari. Most of drugs are of Kashaya-Tikta Rasa, Laghu - Ruksha Guna and Tridosha-Hara which is administered with different Anupanas, found to be effective in Ashmari Chikitsa.
A conceptual review on Bilwadi Gutika in female reproductive system
Authors: Swathi M  , Deepa Karikatti
Published: November 2024

Food acts nutrition and sometimes a medicine. Nowadays the food which are consuming is having reduced amount of nutrition and lack in medicinal action because of use of endocrine disrupting chemicals like preservatives, dyes, taste enhancers, processing of food etc. They can also come through fertilizers which are sprayed to vegetables and fruits. The concept of Gara Visha and Viruddha Ahara is similar to EDC’s. Their action or effect is on all the system but mainly reproduction system. Bilwadi Gutika acts as detoxifying because of Kaphavata Hara action and Visha Hara action.
A Critical Review on Khadiradi Vati - An Ayurvedic Formulation
Authors: Kavya Rashmika  , T. Srinivas  , G. Swarupa Rani  , S. Babu Rao  , Vijaya Laxmi
Published: November 2024

Ayurvedic medicine makes extensive use of herbal and herbo-mineral preparation. Because of its revitalizing qualities, long shelf life, and increased potency even at low doses, Rasaoushadis are significant in Ayurvedic medicine. One such classical multi-ingredient herbo mineral Ayurvedic formulation is Khadiradi Vati. Khadiradi Vati is a traditional Ayurvedic propriety medicine comprising of various plant and mineral based ingredients including Khadira, Javithri, Kankola, Gairika and etc. this herbo mineral preparation is used to treat various oral and skin disorders. It balances Vata, Pitta, Kapha and helps in alleviation of sore throat, reduces hoarseness and increases clarity in voice. It has described in various classical texts and can be used in Kasa, Swasa, Aruchi, Galaroga, Talu Roga, Kanta Roga, Mukha Roga, Kushta, Arsas, Bhagandara. Due to the presence of flavonoids, phytosterols, alkaloids, it acts as anti-inflammatory, anti-oxidant is used in treating tonsilitis, gingivitis, mouth ulcers and etc.
Exploring Basti as Sadhyopranahara Marma through the Lens of Contemporary Anatomy
Authors: Arpitha S  , Vivek A Nair  , Prasanna S
Published: November 2024

The concept of Marma in Ayurveda holds profound significance, representing vital points on the body where life force resides. Among these, Sadhyopranahara Marma is particularly critical, capable of causing immediate death if injured. Basti, one of the 19 Sadhyopranahara Marma, is highlighted for its unique properties and significance. This study aims to explore why Basti is classified as a Sadhyopranahara Marma, integrating classical Ayurvedic principles with contemporary anatomical understanding. The study examines the anatomical structure and functional significance of Basti. It elucidates Basti as the seat of Prana, composed of Alpa Mamsa Shonitha and surrounded by multiple Sira and Snayu. Injury to Basti can lead to severe bleeding and hemodynamic instability, ultimately resulting in death. Comparing Ayurvedic insights with modern anatomical knowledge of the urinary bladder, the study finds parallels in the understanding of injury mechanisms and fatal outcomes. Bladder trauma can lead to hemorrhage, peritonitis, organ dysfunction, and electrolyte imbalance, highlighting the critical nature of this region in both traditional and contemporary medical contexts. In conclusion, the study underscores the timeless relevance of Marma Shastra in understanding human anatomy and physiology. By elucidating the unique attributes of Basti as a Sadhyopranahara Marma, this enriches our understanding of Ayurvedic principles and their integration with modern medical practice. As we bridge the gap between tradition and innovation, the study emphasizes the holistic vision of healthcare that transcends temporal boundaries.
A review article on the managements of Arshas (haemorrhoids)
Authors: Sai Shashank K  , Parvathy S  , Shankar S
Published: November 2024

A haemorrhoid is the most common affecting up to one quarter of all adults according to some estimates. Numerous interventions exist for their management, ranging from topical and medical therapies to outpatient treatments and surgical interventions that aim to fix or excise. The word Arsha is self-explanatory, indicating that the disease troubles a person like an enemy. Arshas can be corelated to haemorrhoids in modern science. Arshas is clinically an engorged condition of haemorrhoidal venous plexus characterized by prolapsed mass per anum, bleeding per anum mainly. In contemporary science there are treatments for haemorrhoids like sclerotherapy, banding, laser ablation, lifestyle modifications, surgical procedures like haemorrhoidectomy and other invasive technique. In Ayurvedic tests Chaturvidha Chikitsa is said, such as Bheshaja (medicinal), Kshara Karma (caustic treatment), Agni Karma (thermal hear burn) and Shastra Karma (surgery). In this review article, treatments from modern as well as Ayurvedic texts are documented so that proctologists around the world get a better understanding about the disease and its exact treatment modalities in both the sciences.
Anxiety - Unlocking the Dynamics and Management in Ayurveda
Authors: Shraddha Naidu  , G.R. Ratre  , Shrikant Naik
Published: November 2024

Ayurveda has the most ingenious approach to achieve complete health as it doesn’t leave any domain unattained, especially mental health. Rajas & Tamas Manas Dosha are responsible for all the psychic disorders including Anxiety which is usually characterized by hyperactivity, state of excessive worry, fear and poor decision-making ability. Its psychopathology affects humans on somatic level as well. Mental health concerns touch most people’s lives directly or indirectly, it can affect a person’s work productivity, their personal and professional lives and in severe cases destroy their quality of life. Ayurveda takes two approaches Drug therapy like use of Medhya Rasayan, through internal as well as external method which enhances the function of intellect & non-drug therapy like Aachar Rasayan, Satwavajaya Chikitsa & Yoga therapy. Anxiety is more chronic as it often overshadowed by other health conditions like GIT problems. Hence exploring presenting problem involving mind-body relationship and finding a synergistic solution is the need of the hour, to reduce the stigma associated with it, by understanding Anxiety in depth from Ayurveda’s point of view.
Pathya and Apathya in Bhagandara: Holistic Approaches to Fistula-in-Ano
Authors: Satya Santosh Sahoo  , P. Hemantha Kumar  , Lokendra Pahadiya  , Hetal Koriya  , Tapaswini Dalasinghray
Published: November 2024

Bhagandara, commonly known as fistula in ano, is a prevalent anorectal condition extensively described in classical Ayurvedic texts. Classified under Ashtamahagada by Acharya Sushruta, it initially appears as a pidika near the anus and transforms into Bhagandara upon rupture. The clinical features of this condition align closely with modern interpretations of fistula in ano, and its recurrent nature presents significant treatment challenges. While contemporary surgical methods offer various options, the management of this ailment remains complex for proctologists. Among Ayurvedic treatments, Ksharasutra has emerged as a particularly effective parasurgical intervention. In addition to surgical approaches, adherence to Pathya (beneficial) and Apathya (harmful) dietary rules plays a crucial role in the management and prevention of recurrence, enhancing overall treatment outcomes. This article explores the holistic understanding of Bhagandara, its clinical manifestations and the importance of diet in achieving optimal health.
The significant relief of Ayurvedic management for Severe Migraine Episodes: A Case Study
Authors: Ritu Pohiya  , Devjinder Singh  , Pramod Kumar Mishra  , Indumati Sharma
Published: November 2024

Migraine is a common and debilitating neurological disorder marked by recurrent, severe headaches that are frequently accompanied by nausea, sensitivity to light, and sensitivity to sound. These migraine attacks can profoundly disrupt daily life and overall well-being. The development of migraines is influenced by a complex interaction of genetic, environmental, and neurovascular factors. Recent studies have enhanced our understanding of migraine mechanisms, highlighting the role of cortical spreading depression and neuropeptides such as calcitonin gene-related peptide (CGRP). Managing migraines effectively often involves a combination of lifestyle changes, medications, and, in some cases, alternative treatments. In Ayurveda, migraine is compared with Ardhavbhedaka (half-headache) which belongs to the Shiroroga. Ardhavbhedaka is primarily associated with imbalances in the Pitta and Vata Doshas due to etiological factors such as eating dry food, eating immediately after a meal, exposure to air from the east, dew, excessive sexual activity, preventing the natural urge of bodily waste, excessive physical labor, develop Ardhavbhedaka.
Ayurveda management of Oral Lichen Planus
Authors: Priyanka Kumawat  , Rajshree Unadkat
Published: November 2024

Background: Oral Lichen Planus (OLP) is a chronic inflammatory disease that affects the mucus membrane of the oral cavity. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+ T cells trigger apoptosis of the basal cells of the oral epithelium. It is characterized by lesions consisting of radiating white, gray, velvety, thread-like papules in a linear, annular and retiform arrangement forming typical lacy, reticular patches, rings and streakes. Although the exact etiology of this disease is still unknown, but some factors are associated with it like dental materials, autoimmunity, food allergies, stress, trauma, bowel diseases, infectious diseases, genetics etc. Aims and Objectives: To study the role of Ayurveda Chikitsa in the management of Oral Lichen Planus. Materials and Methods: A female patient aged 41 years presented with complaints of oral lesion with burning, pain, occasionally bleeding from gums while brushing. Patient was diagnosed with disease Oral Lichen Planus. Patient was treated with administration of Deepana Pachana Aushadhis followed by Trivritta Churna, Guduchyadi Kwatha internally and with Rasayanadi Yoga being used as local application. After the two month’s treatment, a significant response seen in symptoms like burning, pain and bleeding from gums while brushing. Result: There is a need to make treatments that are widely recognized, widely successful, and capable of withstanding systematic replication available. These treatments should be able to significantly reduce the volume, recurrence and impact of Oral Lichen Planus. Conclusion: Ayurveda has great approach in curing the Oral Lichen Planus.
A Case Study on Dushta Vrana w.s.r to Venous Ulcer
Authors: Radhika Pachamalai
Published: November 2024

Vrana in Ayurveda is defined as a structural deformity in the skin and deeper structures, it’s of 2 types - Dushtavrana and Shudhavrana. Dushta Vrana with foul smell has abnormal color with profuse discharge from wound, intense pain and takes long period to heal is said to be Dushta Vrana. The features will vary according to the predominant Dosha. It can be correlated to Chronic wound based on underlying pathology. Chronic wounds are termed ulcers and can be defined as wounds with full thickness in depth and slow healing tendency. In this single case study Dusta Vrana is considered as venous ulcer is one among 4 types of Chronic wound. Venous Ulcer occurs due to abnormal hypertension in the lower third of the leg, ankle and dorsum of foot. Acharya Sushruta has mentioned Shashti Upakrama for the management of Vrana. Here to evaluate the combined effect of Shodhana and Shamana Chikitsa, Classical Virechana, Jalaukaavacharana as a Shodhananga, Shamanaushadi by Kaishora Guggulu, Triphala Guggulu, Gandhaka Rasayana, and Manjishtadi Kashaya, Sthanika Chikitsa by Panchavalkala Kashaya Pariseka and Jathyadi Ghrita. The medicines having Tridosha Shamaka, Vrana Shodhana, Ropana, Vedana Shamaka, Shothahara, Rasayana property showed successful result in treating Dushtavrana.
Ayurvedic management of Alcoholic Liver Disease : A Case Report
Authors: Shruti Arali  , Sidram Guled  , Mythrey RC
Published: November 2024

Alcoholic liver disease (ALD) is one of the most prevalent types of liver disease worldwide. According to a 2023 study, the prevalence rate of alcoholic liver disease in India is 4.8%. This case report deals with a 51-year-old male patient initially came to OPD with complaints of yellowish discoloration of eyes, skin, and urine, loss of appetite, anorexia, distention of the abdomen, bilateral pedal edema, easy fatiguability, weakness and weight loss.  Liver function test shows-high bilirubin and high transaminase, USG of the abdomen shows-Moderate Hepatomegaly with signs of Hepatitis. It was diagnosed as Kostha-Shakhashrita/Bahupitta Kamala based on the etiopathology and investigations.  The patient was treated with Ayurvedic interventions viz, NABB Swarasa, Arogyavardini Vati, Phalatrikadhi Kashaya with Katuki Churna, Patolakaturohinyadhi Kashaya, Laghusoothshekara Rasa and Tab Nirocil were prescribed. After 68 days of treatment protocol, there was marked relief in the symptoms and a reduction in bilirubin and transaminase levels. The above-mentioned oral medications have shown significant results in the present study.
Management of Dustavrana by Chedana Karma and application of Madhu - A Case Study
Authors: Lavesh Jangamshetti  , L. Manonmani  , Mohd. Zahoor Bhat
Published: November 2024

Dusta Vrana management is most complicated problem  encountered by medical practitioner all over the globe, that is non-healing, rapidly growing, disturb the day to day activities of patients, without early and optimal intervention it may ends with amputation of affected limb to save the life, This study reveals that Chedan (debridement) of necrotic patches  followed by  application of Madhu gives tremendous result in healing of ulcers, As per Sushruta Samhita, Lakshana of Dusta Vrana are Dourganda, Putisrava, Twak Mamsadi Kotha etc., In this case we had Lakshanas like Twak Kotha, Dourganda, Atiputisrava, Kandu etc. In Sushruta Samhita, Chikitsa Sthana 1st chapter Sushruta describes Shasti Upakrama for Vrana Chedana and Madhu Lepana is one among them. Chedana is mainly indicated for Dustavrana, Kotha etc., Honey has properties like Vrana Shodana, Vrana Ropana, Vvrana Sandhaniya. A 45 year male patient with wound over lateral aspect of thigh, knee joint and over lateral aspect of tibia associated with pain, itching fever since 1 week. Patient also had a history of admission in allopathic hospital under diagnosis of cellulitis, where in fasciotomy / fasciectomy was done. As the patient didn’t get relief so he approached our hospitals Shalya Tantra OPD. Patient had no comorbidity like diabetic mellitus, hypertension and patient was treated with Chedana Karma and application of Madhu along with Shamana Aushadi which has been discussed here.
Effect of Ksheerbasti and Uttara Basti on Endometrial Fibrosis Induced Infertility (Kshetra Dushti Janya Vandhyatva) - A Case Report
Authors: Deepika Munjal  , Poonam Choudhary
Published: November 2024

Infertility is a disease of male or female, defined by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse. Fibrous scaring of the uterine cavity not only decreases fertility (via impairing embryo implantation) but is also associated with an increased risk of miscarriage and other obstetric conditions. Here is a case study of a 30-years-old female patient residing in Jaipur who consulted in OPD of the National Institute of Ayurveda (NIA) Jaipur on 30-9-23 with the chief complaint of being unable to conceive since 5 years. Her diagnostic Laproscopy & Hysteroscopic findings were suggestive of multiple subserosal fibroid & fibrosed endometrium. Patient was treated with Ayurvedic regime for 5 cycle considered as a Kshetra Dusthi Janya Vandhyatva. The patient missed her period on 8-03-24 and did her urine pregnancy test on 19-3-24, which was found to be positive. From this case study, it is concluded that Ayurvedic intervention are effective in treating infertility due to Endometrial Fibrosis (Kshetra Dushti Janya Vandhyatva).
Garbhini Paricharya and its Clinical Importance
Authors: Sheela Verma  , Anjana Saxena  , Deepika Gupta
Published: November 2024

Ayurveda refers to prenatal care as Garbhini Paricharya, a preventive healthcare system. Pregnant women should receive care from the start of their pregnancy until the baby is born. Given that the health of the mother affects the outcome for the fetus, pregnancy and childbirth are among the most important times in a woman’s life cycle and require special care. The rising incidence of congenital malformations in infants nowadays is a major source of concern for the medical community. These flaws might be mild, large, anatomical, or physiological in character. Prenatal care known as Garbhini Paricharya suggests Ahar, or a certain nutrition plan, Vihar, or a Garbhini way of life, and behavioral changes in the psychological domain. The right Garbhini Paricharya would lead to the fetus developing normally, to a healthy delivery, and to the mother’s ability to endure the hardship of childbirth. Garbhini Paricharya consists of Garbhasthapak Dravyas (substances favorable for maintaining pregnancy), Garbhopaghatakar Bhavas (activities and substances which are damaging to fetus), and Masanumasik Pathya (mouth smart food regimen). The primary goals of advising Garbhini Paricharya are Anupaghata (simple pregnancy), Paripurnatya (ensuring the fetus and mother grow properly), and Sukhaprasava (healthy delivery). Conclusion: Prenatal care should be provided in an integrated manner, that is, in accordance with both current science and Ayurvedic literature, as the ancient Ayurvedic literature detailed in the many Samhitas is not only unique but also scientific as modern medical sciences.