bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Area Deprivation Index in Patients with Invasive Lobular Carcinoma of the Breast: Associations with Tumor Characteristics and Outcomes
Authors: Kaur Mandeep , Patterson Anne , Molina-Vega Julissa , Rothschild Harriet , Clelland Elle , Ewing Cheryl A. , Mujir Firdows , Esserman Laura J. , Olopade Olufunmilayo I. , Mukhtar Rita A.
Published: June 2023

AbstractBackground:
Although investigators have shown associations between socioeconomic status (SES) and outcomes in breast cancer, there is a paucity of such data for invasive lobular carcinoma (ILC), the second most common type of breast cancer. Herein we evaluated the relationship between SES with tumor features and outcomes in stage I to III patients with ILC.
Methods:
We analyzed a prospectively maintained institutional ILC database and utilized the area deprivation index (ADI) to determine neighborhood adversity, an indicator of SES. We used Cox proportional hazards models in Stata 17.0 to evaluate relationships between ADI quintile (Q), race, body mass index (BMI), clinicopathologic features, treatment type, and event-free survival (EFS).
Results:
Of 804 patients with ILC, 21.4% lived in neighborhoods classified as ADI Q1 (least resource-deprived) and 19.7% in Q5 (most resource-deprived). Higher deprivation was significantly associated with larger tumor size (3.6 cm in Q5 vs. 3.1 cm in Q1), increased presence of lymphovascular invasion (8.9% in Q5 vs. 6.7% in Q1), and decreased use of adjuvant endocrine therapy (67.1% in Q5 vs. 73.6% in Q1). On multivariable analysis, tumor size, receptor subtypes, and omission of adjuvant endocrine therapy were associated with reduced EFS.
Conclusions:
These data show that patients with ILC and higher ADI experience more aggressive tumors and differences in treatment. More data evaluating the complex relationships between these factors is needed to optimize outcomes for patients with ILC, regardless of SES.
Impact:
ADI is associated with differences in patients with ILC.
Data from A Metabolically Optimized, Noncytotoxic Low-Dose Weekly Decitabine/Venetoclax in MDS and AML
Authors: Levitz David , Saunthararajah Yogen , Fedorov Kateryna , Shapiro Lauren C. , Mantzaris Ioannis , Shastri Aditi , Kornblum Noah , Sica R. Alejandro , Shah Nishi , Konopleva Marina , Gritsman Kira , Braunschweig Ira , Cooper Dennis L. , Pradhan Kith , Verma Amit , Feldman Eric J. , Goldfinger Mendel
Published: June 2023

AbstractPurpose:
Venetoclax (VEN) added to the hypomethylating agents (HMA) decitabine or azacitidine is the new standard of care for elderly patients with acute myeloid leukemia (AML) and is being evaluated in myelodysplastic syndrome (MDS). Current dosing of HMA/VEN relies on leukemia suppression through cytotoxicity which also impacts normal hematopoiesis. A regimen using once-weekly low-dose decitabine (LDDec) has demonstrated activity in myeloid malignancies. To overcome the severe myelosuppression often seen with HMA/VEN, we evaluated a once-weekly dosing regimen of VEN and LDDec in elderly and/or frail patients who were felt less likely to tolerate severe myelosuppression.
Patients and Methods:
This is a retrospective, single-center analysis of patients with AML, MDS, or chronic myelomonocytic leukemia treated with a once-weekly LDDec/VEN regimen. We also compare this regimen with a cohort treated with standard dosing HMA/VEN.
Results:
In a retrospective cohort of 39 patients, the overall response rate for patients receiving LDDec/VEN for first-line AML and MDS was 88% and 64%, respectively. In patients with TP53 mutations, the composite complete response rate was 71% and the median overall survival was 10.7 months. When compared with 36 patients receiving standard dose HMA/VEN, the LDDec/VEN patients had a longer time on therapy (175 vs. 78 days; P = 0.014) and a trend toward a higher rate of transfusion independence (47% vs. 26%; P = 0.33). Neutropenic fever occurred in 31% of patients, with a median of one hospitalization at any point during treatment.
Conclusions:
This preliminary clinical experience, although retrospective, provides proof-of-activity of noncytotoxic DNA methyltransferase 1–targeting by allowing frequent, sustained drug exposure often not possible with standard HMA/VEN regimens.
SupplementaryTable S7 from Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer
Authors: Wollenzien Hannah , Afeworki Tecleab Yohannes , Szczepaniak-Sloane Robert , Restaino Anthony , Kareta Michael S.
Published: June 2023

Normalized CTA expression from NCI-H209 cell, xenografts, and chemo-treated xenografts (related to Figure 5f)
Supplementary Table S4 from Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma
Authors: Wang Xin , Kutschat Ana P. , Aggrey-Fynn Joana , Hamdan Feda H. , Graham Rondell P. , Wixom Alexander Q. , Souto Yara , Ladigan-Badura Swetlana , Yonkus Jennifer A. , Abdelrahman Amro M. , Alva-Ruiz Roberto , Gaedcke Jochen , Ströbel Philipp , Kosinsky Robyn Laura , Wegwitz Florian , Hermann Patrick , Truty Mark J. , Siveke Jens T. , Hahn Stephan A. , Hessmann Elisabeth , Johnsen Steven A. , Najafova Zeynab
Published: June 2023

Supplementary Table S4 contains L3.6pl TP63-dependent enhancer regions.
Supplementary Table S3 from Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma
Authors: Wang Xin , Kutschat Ana P. , Aggrey-Fynn Joana , Hamdan Feda H. , Graham Rondell P. , Wixom Alexander Q. , Souto Yara , Ladigan-Badura Swetlana , Yonkus Jennifer A. , Abdelrahman Amro M. , Alva-Ruiz Roberto , Gaedcke Jochen , Ströbel Philipp , Kosinsky Robyn Laura , Wegwitz Florian , Hermann Patrick , Truty Mark J. , Siveke Jens T. , Hahn Stephan A. , Hessmann Elisabeth , Johnsen Steven A. , Najafova Zeynab
Published: June 2023

Supplementary Table S3 contains list of genes associated with Gö4Pdx4 super enhancers overlapping TP63.
Supplementary Table S2 from Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma
Authors: Wang Xin , Kutschat Ana P. , Aggrey-Fynn Joana , Hamdan Feda H. , Graham Rondell P. , Wixom Alexander Q. , Souto Yara , Ladigan-Badura Swetlana , Yonkus Jennifer A. , Abdelrahman Amro M. , Alva-Ruiz Roberto , Gaedcke Jochen , Ströbel Philipp , Kosinsky Robyn Laura , Wegwitz Florian , Hermann Patrick , Truty Mark J. , Siveke Jens T. , Hahn Stephan A. , Hessmann Elisabeth , Johnsen Steven A. , Najafova Zeynab
Published: June 2023

Supplementary Table S2 contains GöPdx4 super enhancers regions overlapping TP63
Supplementary Table S5 from Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer
Authors: Wollenzien Hannah , Afeworki Tecleab Yohannes , Szczepaniak-Sloane Robert , Restaino Anthony , Kareta Michael S.
Published: June 2023

Normalized gene expression across NCI-H209 subclones (related to Figure 4)
Supplementary Table S4 from Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer
Authors: Wollenzien Hannah , Afeworki Tecleab Yohannes , Szczepaniak-Sloane Robert , Restaino Anthony , Kareta Michael S.
Published: June 2023

Differential gene expression across NCI-H209 and NCI-H82 cluster (related to Figure 4)
Supplementary Table S3 from Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer
Authors: Wollenzien Hannah , Afeworki Tecleab Yohannes , Szczepaniak-Sloane Robert , Restaino Anthony , Kareta Michael S.
Published: June 2023

Gene module membership and expression of module 5 (related to Figure 1g)
Supplementary Table S2 from Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer
Authors: Wollenzien Hannah , Afeworki Tecleab Yohannes , Szczepaniak-Sloane Robert , Restaino Anthony , Kareta Michael S.
Published: June 2023

Description of samples in the xenograft study
Supplementary Figure S4 from Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer
Authors: Wollenzien Hannah , Afeworki Tecleab Yohannes , Szczepaniak-Sloane Robert , Restaino Anthony , Kareta Michael S.
Published: June 2023

Gene counts and filtering.
Supplementary Figure S2 from Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer
Authors: Wollenzien Hannah , Afeworki Tecleab Yohannes , Szczepaniak-Sloane Robert , Restaino Anthony , Kareta Michael S.
Published: June 2023

Characterization of cell types isolated from the autochthonous scRNA-seq data.
Supplementary Figure S14 from Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer
Authors: Wollenzien Hannah , Afeworki Tecleab Yohannes , Szczepaniak-Sloane Robert , Restaino Anthony , Kareta Michael S.
Published: June 2023

Validation of GAGE2A and PAGE5 shRNAs and overexpression vectors.
Table S2 from CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes
Authors: Koyama-Nasu Ryo , Kimura Motoko Y. , Kiuchi Masahiro , Aoki Ami , Wang Yangsong , Mita Yukiyoshi , Hasegawa Ichita , Endo Yukihiro , Onodera Atsushi , Hirahara Kiyoshi , Motohashi Shinichiro , Nakayama Toshinori
Published: June 2023

Table S2
Figure S1, S2, S3, S4, S5, S6, S7, S8, S9, S10, S11 from CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes
Authors: Koyama-Nasu Ryo , Kimura Motoko Y. , Kiuchi Masahiro , Aoki Ami , Wang Yangsong , Mita Yukiyoshi , Hasegawa Ichita , Endo Yukihiro , Onodera Atsushi , Hirahara Kiyoshi , Motohashi Shinichiro , Nakayama Toshinori
Published: June 2023

Figure S1, S2, S3, S4, S5, S6, S7, S8, S9, S10, S11
TABLE 3 from Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Daniel F. , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B. , Merajver Sofia D. , Merrill Nathan
Published: June 2023

Molecular targeted drugs with very high DSS3 values
TABLE 1 from Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Daniel F. , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B. , Merajver Sofia D. , Merrill Nathan
Published: June 2023

GSEA using the Hallmark gene sets comparing the paired brain metastases and primary breast tumors. Gene sets with FDR < 0.05
Supplementary Data S6 from Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Daniel F. , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B. , Merajver Sofia D. , Merrill Nathan
Published: June 2023

Clinicopathologic characteristics of source patients for brain metastases PDX models: Group B.
Supplementary Data S5 from Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Daniel F. , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B. , Merajver Sofia D. , Merrill Nathan
Published: June 2023

GSEA analysis using the oncogenic, KEGG, and GOBP gene sets.
FIGURE 1 from Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment
Authors: Morikawa Aki , Li Jinju , Ulintz Peter , Cheng Xu , Apfel Athena , Robinson Dan , Hopkins Alex , Kumar-Sinha Chandan , Wu Yi-Mi , Serhan Habib , Verbal Kait , Thomas Dafydd , Hayes Daniel F. , Chinnaiyan Arul M. , Baladandayuthapani Veerabhadran , Heth Jason , Soellner Matthew B. , Merajver Sofia D. , Merrill Nathan
Published: June 2023

Volcano plot of differentially expressed genes comparing the paired brain metastases and primary breast tumor (Group A). The downregulated and the upregulated genes in the brain metastases samples compared with the matched primary breast tumor samples are color coded as blue (down) and red (up).
The Effect of Emotional Intelligence and Logical-Mathematical Intelligence on Accounting Understanding with Confidence as a Moderating Variable
Authors: Pinanggio Mukti , Suyanto  , Padwa Sari Gustin
Published: June 2023

This study aimed to analyze emotional intelligence and mathematical logical intelligence on accounting understanding with self-confidence as a moderating variable. The type of research used in this study was quantitative. In this study, the researcher undertook the primary data through questionnaires with a population of 268 students. The sampling technique used purposive sampling with several criteria obtained from 134 respondents. The data were analyzed by MRA (Moderated Regression Analysis) interaction test. The results of this study yielded that emotional intelligence affects accounting comprehension. Logical mathematical intelligence affects accounting understanding, and self-confidence does not moderate emotional intelligence towards accounting understanding, and self-confidence does not moderate logical-mathematical intelligence towards accounting understanding in students.
Startups in Algeria - Towards the promotion of the economic development movement as an alternative to wealth creation without depending on economic rents
Authors: Souiki Horiya
Published: June 2023

The Algerian legislator sought to establish a legal framework for emerging enterprises whose managers aim to create and market new technologies with the intention of promoting the economic development and encouraging investment and innovation in the field of information and communication technology. For this, he first started by embodying a committee specialized in granting the label of an emerging enterprise or Startup, with the introduction of provisions that simplify the requirements and conditions for establishing a simple Joint-Stock Company with the label of a Startup. For the first time ever, the legislator added a number of amendments to the Labor Law and the Basic Law of Public Function in order to give the employee the possibility to invest in the private sector and establish his own enterprise. In addition, regarding the university student, the legislator gave him a chance to prepare a new form of graduation dissertation project about the creation of startup. In this case, this student can therefore benefit from financial support and funding. This would certainly make the university student a creator of new job positions, which will surely help to reduce the unemployment rate.

The present study aims to carry out an analytical interpretation of the different recent legal texts in order to frame them within the Algerian law.
Materia Medica in a Multilingual Context: Avicenna’s Canon of Medicine and Its Latin Translation of Book II
Authors: Veit Raphaela
Published: June 2023

For centuries, Avicenna’s Canon of Medicine was a crucial text used in medical studies across the Islamicate area as well as in Latin Europe. It was first translated from Arabic into Latin by Gerard of Cremona (d. 1187) and his students in Toledo. This article focuses on the second book of the Canon which is dedicated to the description of simple drugs. It is in this part of the Canon that we find many references not only to borrowings from Ancient Greek but also from Eastern material. A careful comparison of the Arabic text and the Latin translation demonstrates that the Latin translation was often imprecise, and while it eliminated some but not all obvious Muslim religious references, it did not try to adapt the material to the Latin readership in other ways.
Food in the Frankish Levant: a Case Study of Cultural Borrowing
Authors: Bronstein Judith
Published: June 2023

The Crusader movement called for the liberation of the Holy Land and the expulsion of non-Christians. Yet in reality, the Frankish states of Edessa, Antioch, Tripoli and Jerusalem, established as the result of the Crusades, were to become heterogeneous societies, with a plurality of ethnic and religious groups ruled by a Latin Frankish elite. In recent decades, historians, art historians and archaeologists have turned much attention to the study of influences and cultural borrowing in artistic, architectural, religious, military, governmental, administrative and intellectual activities that resulted from almost two centuries of co-existence of the Latins with the local population in the Levant: Eastern Christians, Muslims, and Jews. This article strives to contribute to this ongoing discussion by analyzing some aspects of everyday life in the Frankish Levant, focusing mainly on foodstuffs and food habits. The study of preservation of culinary traditions, consumption of new food products, as well as technological and administrative changes related to food production, are valuable tools in understanding coexistence and cultural borrowing in the Frankish Levant.
Cringing at Benevolence
Authors: McCrary Charles
Published: June 2023

Engaging with Logan’s third chapter, on the American Seamen’s Friends Society, this piece reflects on what it means to cringe in the context of a benevolent or charitable relationship. People cringe when they are made painfully aware of the gap between their self-conception (and/or their ideal self) and the way others perceive them. Logan shows us, in her study of the ASFS, the cringeworthy nature of antebellum benevolent societies: they learned about the objects of their benevolence (in this case, sailors), performed rituals alongside them, and attempted to befriend them, and yet they did not ultimately want to be them or be like them but, rather, to change them.
Awkward History, Awkward Theory
Authors: MacCormack Ian
Published: June 2023

Based on a contribution to a panel discussion on Dana Logan’s Awkward Rituals, this essay addresses the first chapter of the book, in which Logan discusses the rites of Freemasons in the early American republic. It considers the particular significance of Masonic ritual practice with respect to Logan’s arguments about patterns of change in pre- and post-Revolutionary America; and reflects on the general theoretical import of this notion of ritual awkwardness, embodied by the Freemasons, considered as a form of purposive activity. It raises questions about the broader applicability in comparative religious studies of Logan’s insights, both for studying history and for thinking about ritual.
Response to Symposium on Awkward Rituals
Authors: Logan Dana
Published: June 2023

In this response to the symposium on Awkward Rituals, Logan responds to questions such as “do her subjects know that they are awkward?” “are awkward rituals effective?” “is this a theoretical or a historical intervention?” and “what is the role of American exceptionalism in this argument?” In response to these questions the author looks towards a future of ritual studies in which we might take seriously the limits of a scholars’ temporal and geographical boundaries while also building new genealogies of ritual as a category of analysis and practice grounded in historical exchanges.
Theorizing Awkwardness, with Style, in the Study of Religion: A Forum on Dana W. Logan’s Awkward Rituals (2022)
Authors: Hazard Sonia
Published: June 2023

The 2022 meeting of the American Academy of Religion in Denver featured a book panel on Dana W. Logan’s Awkward Rituals: Sensations of Governance in Protestant America (University of Chicago Press, 2022). This essay introduces a forum based on the panel, featuring four scholars representing diverse subfields in religious studies: Ian MacCormack, Charles McCrary, Constance Furey, and Marko Geslani. It argues that Awkward Rituals, though embedded in ritual studies and the historiography of American religion, is a generative theoretical text for many areas of inquiry in the wider study of religion: the disjunctures and incoherences in religions; the practical applications of a mind/body dualism; the uses of the personal experiences of the scholar; and the endurance of comparison as a method.
The ‘House of Song’, the *‘House of Clay’, Arm. gerezman, and Caucaso-Albanica
Authors: Schwartz Martin
Published: June 2023

This paper begins with an examination of the phrase /garah dmāna-/, the most common designation for Paradise in the Gathas, for which the traditional translation ‘House of Song’ is upheld. Its dualistic opposite /drujah dmāna-/ ‘House of Wrongness’ for Hell leads to the question of why for Paradise one doesn’t have the expected opposite *‘House of Rightness’ instead of ‘House of Song’. The answer proceeds from the etymologically unrelated Armenian gerezman ‘grave, tomb’, whose origin has been hitherto unknown, despite attempts toward its etymology. In view of the Indo-European phrase for the grave (i.e., burial mound) as ‘the House of Clay’, it is then suggested that the Arm. word is from a Median phrase, which is reconstructed as *gṛda- *zmani- ‘*clay (*zmani-) house (*gṛda-)’. The phonic similarity of this phrase to /garah dmāna-/ (/garah/ ‘song’s’ and /dmāna-/ ‘house’), with referential contrast is then seen as the chief motivation for Zarathushtra’s use of /garah dmāna-/ for ‘Paradise’. Then there ensues a discussion of the archeological-historical contexts for the latter development. Next, a phonologically systematic account is offered for Arm. gerezman becoming “Caucasian Albanian” garazman ‘grave, tomb’, in accord with hitherto unnoted aspects of “Caucasian Albanian” historical vocalism. The modern Udi derivative of garazman, i.e. gärämzä, is also accounted for. The loanwords in “Caucasian Albanian” are then divided into two main strata, first the Armenian (Iranian loans and indigenous Arm. words), including some forms from Armenian antedating Armenian literacy, and second a stratum of words, which are here called “Parthic”, of a vintage par with Manichean Parthian. These “Parthic” words, with their religious references, point to an Iranian group which (after the Armenian phase of loanwords) influenced the development of Christianity among the “Caucasian Albanians”, suggesting the existence of a “Christian Parthian”.
Visuo-Tactile Congruence Leads to Stronger Illusion Than Visuo-Proprioceptive Congruence: a Quantitative and Qualitative Approach to Explore the Rubber Hand Illusion
Authors: Bartoletti Roxane L. , Denis-Noël Ambre , Boulvert Séraphin , Lopez Marie , Faure Sylvane , Corveleyn Xavier
Published: June 2023

The Rubber Hand Illusion (RHI) arises through multisensory congruence and informative cues from the most relevant sensory channels. Some studies have explored the RHI phenomenon on the fingers, but none of them modulated the congruence of visuo-tactile and visuo-proprioceptive information by changing the posture of the fingers. This study hypothesizes that RHI induction is possible despite a partial visuo-proprioceptive or visuo-tactile incongruence. With quantitative and qualitative measures, we observed that gradual induction of the sense of body ownership depends on the congruence of multisensory information, with an emphasis on visuo-tactile information rather than visuo-proprioceptive signals. Based on the overall measures, the RHI observed went from stronger to weaker with full congruence; visuo-proprioceptive incongruence and visuo-tactile congruence; visuo-proprioceptive congruence and visuo-tactile incongruence; full incongruence. Our results confirm that congruent visual and tactile mapping is important, though not mandatory, to induce a strong sense of ownership. By changing index finger and thumb postures rather than the rotation of the whole hand, our study investigates the contribution of visuo-proprioception and postural congruence in the field of RHI research. The results are in favor of a probabilistic multisensory integration theory and do not resonate with rules and constraints found in internal body models. The RHI could be illustrated as a continuum: the more multisensory information is congruent, the stronger the RHI.
Strengthening Capacity in Ocean Governance
Authors: Young Margaret A.
Published: June 2023

Ocean governance presents special challenges for States in understanding and carrying out their obligations. The United Nations Convention on the Law of the Sea is supported by secretariats that provide capacity building, training and technical assistance. Yet ocean governance is fragmented, and there are many multilateral and regional institutions that have competences in fisheries, climate change, trade, shipping and other aspects of ocean affairs. Challenges in inter-regime coordination arise, both practically and theoretically. This article describes collaborative training initiatives in ocean governance in the Asia-Pacific, to which UN agencies, the World Bank and academic partners contribute. It seeks to account for these activities according to the precepts of regime interaction and the duty to cooperate in international law, and demonstrates the importance of an inclusive approach to learning and capacity-building in ocean governance.
Energy Storage Governance in the Asia-Pacific through the Law of the Sea Convention: Exploring Bottlenecks and Enablers of Regulating Offshore Wind Combined with Energy Storage
Authors: Colombo Esmeralda
Published: June 2023

Following projections of high economic and demographic growth, the Asia-Pacific region is poised to take the lead in the global production of offshore wind energy. A critical barrier is the intermittency of renewables, increasing the need for energy storage capacity to conserve energy harvested from the ocean. The bankability of energy storage systems combined with offshore wind power remains low and depends on varied policy frameworks. Meanwhile, the potential of the Law of the Sea (los) Convention for storage governance is underexplored. This paper highlights current regulatory bottlenecks and enablers to energy storage based on the los Convention and comparative policy research. It focuses on hydrogen as an energy carrier to store offshore wind energy, demonstrating how energy justice and environmental stewardship can result from ocean-based storage capacity developments. Ultimately, it aims to facilitate access to financing to increase the storage capacity of the Asian-Pacific sustainable blue economy.
A New wto Protocol on Fisheries Subsidies: Potential Implications for the South China Sea Disputes
Authors: Espenilla Jacqueline F.
Published: June 2023

For close to two decades, wto member countries have discussed the possibility of disciplining the practice of subsidizing fishing activities. Concrete progress has been made as there is now a consensus on eliminating certain forms of fisheries subsidies that contribute towards overcapacity, overfishing and illegal unreported and unregulated fishing. In June 2022, at the end of 12th Ministerial Conference in Geneva, Switzerland, the Agreement on Fisheries Subsidies (afs) was finally adopted. Against this backdrop, this paper will attempt to investigate the role that the afs might play in arresting the collapse of global fish stocks. Part i provides a brief background on the state of global fisheries and the role of subsidies in their depletion. Part ii discusses the key features of and contentious issues in the afs. Finally, Part iii considers the potential implications of the afs on disputed waters such as the South China Sea.
Canada
Authors: Smith J.J.P.
Published: June 2023

With the question of sovereignty over Hans Island settled between Canada and Denmark, all territorial claims among Arctic states have been resolved. The 2022 agreement between the two states is discussed in the context of their cooperation in oceans matters, including a contemporaneous minor adjustment of a 1972 seabed boundary and coordinated extended continental shelf claims. The provision for the access of indigenous Inuit people to Hans Island is considered. The 2022 agreement as an exemplar of acting in mutual interest toward resolving a maritime territorial dispute is reviewed.
The U.S.-China “Taiwan Strait” Confrontation: Korea to Follow International Law and Maintain Strategic Ambiguity
Authors: Lee Seokwoo
Published: June 2023

Korea’s respect for the United States Forces Korea (usfk)’s strategic flexibility as an ally to the U.S. is an entirely separate issue from Korea becoming a party to the Taiwan conflict. To uphold peace and security in the Taiwan Strait, Korea should instead, respect the “one China” policy that is central to the security of East Asia and the diplomatic relations between China and other countries. As such, regarding the issues surrounding the Taiwan Strait, for diplomatic security, restraint and strategic ambiguity are necessary to stabilize the status quo.
Fossil Neuropterida (Insecta: Neuroptera and Raphidioptera) from the middle Eocene Kishenehn Formation, Montana, USA
Authors: JEPSON JAMES E. , MAKARKIN VLADIMIR N.
Published: June 2023

The neuropterid (Neuroptera and Raphidioptera) fauna of the middle Eocene Coal Creek Member (Kishenehn Formation), U.S.A. is documented. Three families of Neuroptera (Ascalaphidae, Chrysopidae, Hemerobiidae) and two families of Raphidioptera (Raphidiidae, Inocelliidae) are recorded. Five new species and three new genera are described: Pseudoameropterus ambiguus gen. et sp. nov. (Ascalaphidae), Minimochrysa latialata gen. et sp. nov., Palaeochrysa greenwalti sp. nov., P. minor sp. nov. (Chrysopidae: Nothochrysinae), Macrostigmoraphia diluta gen. et sp. nov. (Raphidiidae). Two indeterminate species are also recorded: Megalomus-group gen. et sp. indet. (Hemerobiidae) and Neuroptera fam. gen. et sp. indet. The only previously described neuropterid from the deposit is the raphidiopteran Paraksenocellia australis Makarkin et al. 2019 (Inocelliidae). The neuropterid assemblage suggests a subtropical semi-arid climate of the Coal Creek Member.
A new species of freshwater crab of the genus Chaceus Pretzmann, 1965 (Brachyura: Decapoda: Pseudothelphusidae) from La Guajira, including distribution and a key to the species of the genus
Authors: CAMPOS MARTHA R. , PUERTA DARIO A.
Published: June 2023

We describe and illustrate a new species of Chaceus Pretzmann, 1965, from the Regional Natural Park of the Serranía de Perijá, La Guajira Department, Colombia. This increases the number of Chaceus species to ten, three of them with records only from Venezuela. The species of this genus are distributed in the Sierra de Santa Marta of Colombia and the Serranía de Perijá of Colombia and Venezuela. We distinguished the new species from its congeners mainly by the third maxilliped, with an exopod that is 0.60–0.62 the length of ischium, and by the morphology of the first male gonopod, particularly by the shapes of the mesial, marginal, and lateral processes. We include the distribution of the Chaceus species here and a key for the identification of the species based on the morphology of the first male gonopod.
New genus of Lumbriculidae (Annelida, Clitellata) from a karst spring in the Cantabrian Mountains, northern Spain
Authors: RODRIGUEZ PILAR
Published: June 2023

The groundwater worms of the family Lumbriculidae exhibit high diversity and endemism in southern Europe. All stygobiont lumbriculid species known so far in this region belong to six genera. In the present study, a new stygobiont lumbriculid Fendia cantabrica n. gen. n. sp. is described, mainly based on distinct characteristics of the male duct structure. The male duct is semiprosoporous and the spermathecae (two pairs) are postatrial, starting in the ovarian segment. These characteristics are shared with only two lumbriculid genera: the Nearctic Eremidrilus and Holarctic Trichodrilus. The new genus is clearly distinguished from the former by the absence of proboscis, and from both genera by a remarkably complex structure of the atrium: a very strong musculature organized in several crossed layers, a protrusible penis with a singular hydrostatic skeleton, and two prostate glands, which join separately to the atrial ampulla by short stalks.
A Decadal Climate Service for Insurance: Skillful Multiyear Predictions of North Atlantic Hurricane Activity and U.S. Hurricane Damage
Authors: Lockwood Julia F. , Dunstone Nick , Hermanson Leon , Saville Geoffrey R. , Scaife Adam A. , Smith Doug , Thornton Hazel E.
Published: June 2023

North Atlantic Ocean hurricane activity exhibits significant variation on multiannual time scales. Advance knowledge of periods of high activity would be beneficial to the insurance industry as well as society in general. Previous studies have shown that climate models initialized with current oceanic and atmospheric conditions, known as decadal prediction systems, are skillful at predicting North Atlantic hurricane activity averaged over periods of 2–10 years. We show that this skill also translates into skillful predictions of real-world U.S. hurricane damage. Using such systems, we have developed a prototype climate service for the insurance industry giving probabilistic forecasts of 5-yr-mean North Atlantic hurricane activity, measured by the total accumulated cyclone energy (ACE index), and 5-yr-total U.S. hurricane damage (given in U.S. dollars). Rather than tracking hurricanes in the decadal systems directly, the forecasts use a relative temperature index known to be strongly linked to hurricane activity. Statistical relationships based on past forecasts of the index and observed hurricane activity and U.S. damage are then used to produce probabilistic forecasts. The predictions of hurricane activity and U.S. damage for the period 2020–24 are high, with ∼95% probabilities of being above average. We note that skill in predicting the temperature index on which the forecasts are based has declined in recent years. More research is therefore needed to understand under which conditions the forecasts are most skillful.

Significance Statement

The purpose of this article is to explain the science and methods behind a recently developed prototype climate service that uses initialized climate models to give probabilistic forecasts of 5-yr-mean North Atlantic Ocean hurricane activity, as well as 5-yr-total associated U.S. hurricane damage. Although skill in predicting North Atlantic hurricane activity on this time scale has been known for some time, a key result in this article is showing that this also leads to predictability in real-world damage. These forecasts could be of benefit to the insurance industry and to society in general.
Designing three-dimensional changed spacer weft-knitted fabrics for efficient absorption and quick-drying partitioned garments
Authors: Li Tianjiao , He Yin , Wang Chunghong , Fu Guangwei , Wang Yue , Gao Huan , Zhao Run , Wang Yuping
Published: June 2023

Enhancing the thermal-wet comfort of garments is a key factor in sportswear research. In this study, we designed a new three-dimensional moisture conduction structure model, developed double-sided fabrics of a changed spacer weft-knitted structure, and compared them with single-sided plain stitch and cellular structure fabrics, focusing on the morphology, basic structural parameters and absorption, and quick-drying performance. The findings indicated that the changed spacer weft-knitted fabric consisting of 18 tex Tencel and 33.3 tex (96 f) recycled polyester filament has a smaller surface density and thickness, the water absorption of 436%, the water evaporation rate of 0.354 g/h, and the water vapor transmission of 7476.75 g/(m2 · d). Compared with other fabrics, it has excellent absorption and quick-drying performance. Partitioned T-shirts were designed by using the human body sweating law, and four fabrics were applied to one to four areas according to the sweating degree. Through infrared image monitoring and subjective evaluation, we concluded that the partitioned T-shirt has efficient absorption and quick-drying ability, and has potential to be applied to the development of thermal-wet comfort sportswear.
Color-patterned fabric defect detection based on the improved YOLOv5s model
Authors: Wang Yuekun , Xu Yang , Yu Zhiqi , Xie Guosheng
Published: June 2023

The complex background pattern of color-patterned fabrics, the small target of some defects, the difficulty separating them from the background, and the extreme aspect ratio present challenges for their automated, real-time detection. To solve the above problems, the YOLOv5s-based color-patterned fabric defect detection algorithm was proposed by combining lightweight modules. For the small target defects of color-patterned fabrics, coordinate attention was introduced in the feature extraction part to guide the model to focus entirely on the target defect area and suppress the background noise of color-patterned fabrics. Meanwhile, the bidirectional feature pyramid network was introduced in the feature fusion part to give different fusion weights to the extracted feature maps, improve the efficiency of feature fusion, and guide the model further to distinguish the fabric defects from the color-patterned background. Finally, the k-means algorithm was used to generate anchor boxes for the extreme aspect ratio of fabric defects to improve the training efficiency and accuracy of the model. Self-built datasets were experimented with to verify the improved model’s detection effect. The results show that the improved YOLOv5s model can reach 87.7% and 0.881 in mean average precision and F1 score, which are 2.3% and 0.02 better than the original model, respectively. The detection speed of the improved YOLOv5s model reached 60.24 frames per second (GPU 1660). After deployment on the fabric defect detection platform, the speed of detecting color-patterned fabrics can reach 15 m/min.
Harnessing artificial intelligence in the post-COVID-19 era: A global health imperative
Authors: Gulumbe Bashar Haruna , Yusuf Zaharadeen Muhammad , Hashim Abubakar Muhammad
Published: June 2023

Despite the World Health Organization's declaration that the COVID-19 global emergency has ended, the threat of future pandemics remains a significant concern. This paper highlights the potential role of Artificial Intelligence (AI) in strengthening global health systems and mitigating future health crises. We discuss AI's proven utility throughout the COVID-19 pandemic, including disease surveillance, diagnostics, and drug discovery. AI's ability to rapidly analyze vast amounts of data to derive accurate trends and predictions underscores its superiority over traditional computer technology. However, the effective and ethical implementation of AI encounters significant challenges, including a pronounced digital divide, with applications mainly concentrated in high-income countries, thus exacerbating health inequities. We argue for international cooperation to enhance digital infrastructure in low- and middle-income countries, tailoring AI solutions to local needs, and addressing ethical and regulatory issues. The importance of maintaining evidence-based practice, rigorous evaluation of AI's impact, and investment in AI education and innovation are stressed. Ultimately, the potential of AI in global health systems is clear, and tackling these challenges will ensure its robust contribution to global health equity and resilience against future health crises.
Korean preservice music teachers’ perceptions of blended learning in music education course
Authors: Shin Jihae
Published: June 2023

Previous studies have examined the effectiveness of blended learning in various learning contexts, including music classes in public schools and music teacher education programs. However, research on the relative importance of both technology-based instruction and traditional classroom environments is lacking. This study examined the experiences of Korean preservice music teachers in a blended learning environment and demonstrated the need for an appropriate time period between online and face-to-face learning, especially for those with little experience in theoretical and practical music education. While a face-to-face classroom was found to be a crucial setting for preservice music teachers to gain various perspectives on class materials with the help of peers, a few found it challenging to explain their understandings to others in a group and express their opinions about specific school scenarios. Finally, formal question time on an online platform that maintains anonymity encouraged preservice music teachers to actively participate in in-class activities, and the combination of theory and practice was perceived as a major strength of blended learning.
Efficacy and safety of vena cava filters in preventing pulmonary embolism: A systematic review and meta-analysis
Authors: Miao Huang-Tai , Li Xiao-Ying , Zhou Can , Liang Ying , Nie Shao-Ping
Published: June 2023

Objectives

To assess the treatment effectiveness of inferior vena cava filters (IVCF) versus non-IVCF for patients undergoing varies conditions.

Methods

We systematically searched the databases to identify eligible RCTs from their inception up to 9/20/2020. The primary endpoint was pulmonary embolism (PE), while the secondary endpoints included deep-vein thrombosis (DVT), major bleeding, and all-cause mortality. The RRs with 95% CIs were applied as effect estimates for the treatment effectiveness of IVCF versus non-IVCF and calculated by using the random-effects model.

Results

1,137 patients of 5 RCTs were enrolled. There were no significant differences between IVCF and non-IVCF for the risk of PE, major bleeding, and all-cause mortality, while the risk of DVT was significantly increased for patients treated with IVCF.

Conclusions

The use of IVCF did not yield any benefits on PE, major bleeding, and all-cause mortality risk for patients undergoing various conditions, while the risk of DVT was significantly increased for patients treated with IVCF.
Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
Authors: James Shaun , Sanggaard Simon , Akif Adil , Mishra Sandeep K , Sanganahalli Basavaraju G , Blumenfeld Hal , Verhagen Justus V , Hyder Fahmeed , Herman Peter
Published: June 2023

Carbon dioxide (CO2) is traditionally considered as metabolic waste, yet its regulation is critical for brain function. It is well accepted that hypercapnia initiates vasodilation, but its effect on neuronal activity is less clear. Distinguishing how stimulus- and CO2-induced vasodilatory responses are (dis)associated with neuronal activity has profound clinical and experimental relevance. We used an optical method in mice to simultaneously image fluorescent calcium (Ca2+) transients from neurons and reflectometric hemodynamic signals during brief sensory stimuli (i.e., hindpaw, odor) and CO2 exposure (i.e., 5%). Stimuli-induced neuronal and hemodynamic responses swiftly increased within locally activated regions exhibiting robust neurovascular coupling. However, hypercapnia produced slower global vasodilation which was temporally uncoupled to neuronal deactivation. With trends consistent across cerebral cortex and olfactory bulb as well as data from GCaMP6f/jRGECO1a mice (i.e., green/red Ca2+ fluorescence), these results unequivocally reveal that stimuli and CO2 generate comparable vasodilatory responses but contrasting neuronal responses. In summary, observations of stimuli-induced regional neurovascular coupling and CO2-induced global neurovascular uncoupling call for careful appraisal when using CO2 in gas mixtures to affect vascular tone and/or neuronal excitability, because CO2 is both a potent vasomodulator and a neuromodulator.
Effects of interleukin-23 on the activation of mucosal-associated invariant T cells from oral lichen planus
Authors: Wang Fang , Zhang Xiu-Li , Yang Jing-Ya , Zhou Gang
Published: June 2023

Objective

Oral lichen planus (OLP) is a T cell-mediated inflammatory condition in the oral cavity. Mucosal-associated invariant T (MAIT) cells are gaining more relevance in immune diseases because they can be activated by cytokines without T cell receptor stimulation. Herein, we tested the effect of interleukin-23 (IL-23) on the activation status of OLP MAIT cells.

Methods

Peripheral blood mononuclear cells (PBMCs) isolated from OLP patients were stimulated by IL-23 in the absence or presence of phorbol myristate acetate (PMA) and ionomycin. The activation status of MAIT cells was analyzed by flow cytometry after staining for CD3, CD4, CD8, CD161, TCR Vα7.2, and CD69.

Results

The fraction of MAIT cells in OLP peripheral blood was approximately 0.38% to 3.97%, and CD8+ subpopulations overwhelmed CD4+ cells. The mean percentages of OLP MAIT cells in PBMCs and CD8+MAIT cells in MAIT cells were approximately 40%. PMA and ionomycin significantly increased CD69 expression on OLP T cells, MAIT cells, and CD8+MAIT cells. Cells with enhanced activation had different responsiveness to exogenous IL-23, showing increased CD69 expression on OLP T cells, decreased CD69 on OLP CD8+MAIT cells, and no significant change on OLP MAIT cells.

Conclusions

IL-23 showed different effects on the activation status of OLP MAIT cells and CD8+MAIT cells.
Prophylactic cannula cricothyroidotomy and percutaneous oxygen insufflation with the Rapid-O2®: A simple and effective tool for enhancing safety in difficult airway management
Authors: Wexler Sivan , Prineas Stavros N
Published: June 2023

Prophylactic cannula cricothyroidotomy is a recognised technique for actual or potential difficult airway management, where it confers a number of technical and non-technical benefits. Oxygenation with this technique is traditionally achieved by way of pressure-regulated, high flow jet ventilation and requires specialised equipment and considerable expertise for safe use, neither of which are always readily available. As an alternative, we describe the management of two patients with progressive upper airway obstruction in whom prophylactic cannula cricothyroidotomy and oxygen insufflation were performed using equipment which we consider is safer, widely available and already familiar to most anaesthetists throughout Australia.