bluuebunny/crossref_metadata_2025 huggingface dataset:
Multicolor Ramsey Numbers via Pseudorandom Graphs
Authors: He Xiaoyu , Wigderson Yuval
Published: February 2020

A weakly optimal $K_s$-free $(n,d,\lambda)$-graph is a $d$-regular $K_s$-free graph on $n$ vertices with $d=\Theta(n^{1-\alpha})$ and spectral expansion $\lambda=\Theta(n^{1-(s-1)\alpha})$, for some fixed $\alpha>0$. Such a graph is called optimal if additionally $\alpha = \frac{1}{2s-3}$. We prove that if $s_{1},\ldots,s_{k}\ge3$ are fixed positive integers and weakly optimal $K_{s_{i}}$-free pseudorandom graphs exist for each $1\le i\le k$, then the multicolor Ramsey numbers satisfy\[\Omega\Big(\frac{t^{S+1}}{\log^{2S}t}\Big)\le r(s_{1},\ldots,s_{k},t)\le O\Big(\frac{t^{S+1}}{\log^{S}t}\Big),\]as $t\rightarrow\infty$, where $S=\sum_{i=1}^{k}(s_{i}-2)$. This generalizes previous results of Mubayi and Verstra\"ete, who proved the case $k=1$, and Alon and Rödl, who proved the case $s_1=\cdots = s_k = 3$. Both previous results used the existence of optimal rather than weakly optimal $K_{s_i}$-free graphs.
A Sensitive Voltammetric Sensor Based on Au Nanoparticle Decorated Graphene Nanosheets Modified Glassy Carbon Electrode for Determination of Acetylcholine in Presence of Dopamine
Authors: Safaei Mohadeseh
Published: February 2020

In this study the electro oxidation of acetylcholine (ACh) in pH 7.0 phosphate buffer solution (PBS) was investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) with the modified glassy carbon electrode (GCE) by Au nanoparticle decorated graphene nanosheets (Au NPs/GNs). DPV is a rapid and sensitive electro analytical technique for determination of acetylcholine in presence of dopamine (DA). Using DPV technique, the current was linear within a concentration range of 0.1-700.0 µM of acetylcholine. The detection limit of the method for acetylcholine is 0.04 µM (S/N=3). Diffusion coefficient, D, and charge transfer coefficients, α, have been determined for oxidizing acetylcholine at the modified surface. The applicability of the proposed method was shown by the successful analysis of acetylcholine in real sample.
Complex perianal fistula in patient with Mayer-Rokitansky-Kuster-Hauser syndrome
Authors: Gutiérrez Delgado MP , Ruiz López M , Collado Alcázar J , Mera Velasco S , Santoyo Santoyo J
Published: February 2020

Introducción: el síndrome de Mayer-Rokitansky-Kuster-Hauser (MRKH) afecta a 1/4.000-5.000 recién nacidos, consistiendo en un fallo en el desarrollo de útero y vagina. Las malformaciones anorrectales asociadas a este síndrome son raras, propiciando la aparición de síntomas más precoces en la infancia.

Caso clínico: mujer de 28 años con MRKH con fístula perianal compleja intervenida en varias ocasiones sin conseguir un tratamiento definitivo de la misma. En resonancia magnética se aprecia trayecto transesfinteriano junto con colecciones anteriores y posteriores a aparato genital. Se interviene de forma conjunta en dos tiempos con Cirugía Plástica, realizándose fictulectomía con confección de neovagina mediante colgajos Singapore. La paciente se encuentra actualmente sin sintomatología perianal.

Discusión: existen dos subtipos de MRKH, el tipo I o típico en el que se describe únicamente la malformación uterovaginal y el tipo II o atípico en el que aparecen asociadas otras malformaciones. Existen pocos casos publicados en la literatura de síndrome de MRKH asociado a malformaciones anorrectales, siendo la más común la fístula rectovestibular. No existe consenso sobre la conveniencia de reparación de ambas anomalías en un mismo acto quirúrgico o en dos actos.
La esperanza-desesperanza y el manejo de la agresividad en estudiantes universitarios de Puerto Rico y de Argentina: un estudio transcultural
Authors: Pereyra Mario , Bruno Jorge
Published: February 2020

Se investiga la esperanza-desesperanza y las respuestas ante el agravio, en tres muestras de estudiantes universitarios, de dos diferentes países —Puerto Rico (n = 103) y la Argentina (n = 226)—, y de diferentes contextos culturales (Centro y Norteamérica, Buenos Aires y Entre Ríos) a fin de comparar si la estructuración del tiempo y el manejo de la agresividad están mediatizados por la cultura o, como presupone la literatura, constituyen dimensiones intrínsecas de la personalidad.
El agotamiento emocional en los profesores de Nuevo León, México: un estudio exploratorio de géneros
Authors: Grajales Guerra Tevni
Published: February 2020

Según la teoría del agotamiento emocional, éste se presenta con mayor frecuencia entre personas que manifiestan un alto grado de involucramiento en sus tareas laborales motivadas por metas poco realistas suponiéndose una relación de causalidad entre involucramiento y agotamiento emocional. Esta investigación, realizada con una muestra aleatoria estratificada de 750 sujetos seleccionados de entre más de 5,000 profesores de preparatoria del Estado de Nuevo León, México, observa, desde la perspectiva del género, la forma como los docentes experimentan el agotamiento emocional, la satisfacción laboral y el grado de involucramiento en su trabajo. Los instrumentos utilizados fueron el componente de agotamiento emocional del MBI de Maslach y Jackson (1997), el factor J de la escala de Jenkins (1992) y el cuestionario de satisfacción de docentes elaborado por Viera (1998). Los docentes varones mostraron una tendencia a disminuir su involucramiento en el trabajo en la medida en que su agotamiento emocional aumenta, en tanto las profesoras no mostraron relación significativa entre el agotamiento emocional y el grado de involucramiento en el trabajo. Esta situación llama la atención dado que las mujeres observadas experimentan niveles de agotamiento emocional significativamente mayores que los varones. Los hombres, con menores niveles de agotamiento emocional, claudican con mayor facilidad ante el involucramiento en su trabajo. Los profesores, que dicen involucrarse más en su trabajo, reportan menores niveles de agotamiento emocional en contraste con las profesoras, quienes no manifiestan cambio en su involucramiento en el trabajo.
Roles, funciones y competencias en la educación a distancia en México
Authors: Rocha Ruiz Ernesto
Published: February 2020

El propósito de esta investigación fue determinar los roles, las funciones y las competencias de los profesionales de la educación a distancia en México. Con esta finalidad se identificaron 118 expertos en educación a distancia y se recabaron sus percepciones usando la metodología Delphi, en un proceso de doble vuelta. Los resultados revelaron la existencia de 12 roles, 90 funciones y 34 competencias que se pudieron agrupar para construir un modelo de competencias, aplicable al campo de la educación a distancia en México.
Catalytic Activity of Tungstophosphorous Acid Supported on Mesoporous Silica for Glycerol Acetalisation to Glycerol Formal
Authors: Trifoi Ancuta , Turcanu Andreea , Doukeh Rami , Gherman Timea , Filip Petru , Bombos Mihaela
Published: February 2020

For the acetalization reaction between glycerol and formaldehyde two mesoporous catalyst were prepared, characterized and tested. Mesoporous silicas (MCM-41 and HMS) were synthesized and used as supports for the phosphotungstic acid based catalysts. Glycerol was converted to glycerol formal through a solventless acetalization reaction with formaldehyde catalyzed by tungstophosphorous acid supported on two type of mesoporous silica (30PW/MCM41 and 30PW/HMS). The reaction was carried out in a batch reactor, at 120�C, using 2% catalyst. The highest yield ] 98.5% was achieved over mesoporous 30PW/HMS catalyst. Catalyst characterization was performed by determining the textural characteristics, acid strength and by SEM analyses. The catalytic activity of the catalysts was compared, using the same conditions with two comercial acid catalysts : Amberlyst 15 and p-toluen sulphonic acid on polymer support (PTS/polymer).
Hybrid Materials Based on Multi-walled Carbon Nanotubes with Antimicrobial Properties
Authors: Ionita Daniela , Ungureanu Camelia , Prodana Mariana , Negru Andrada Maria , Enachescu Marius
Published: February 2020

In the present paper were prepared four types of sample consisting of multi-walled carbon nanotubes functionalized with carboxyl groups (MWCNT-COOH being the reference sample) and further functionalized with ZnCl2, MgCl2, AgNO3 and CuCl2. The samples were submitted to scanning electron microscopy (SEM), Raman microscopy, scanning transmission electron microscopy (STEM), and determined the antimicrobial character.
Corrosion Behavior of Some Steels in Ionic Liquids Based on Choline Chloride
Authors: Neacsu Elena Ionela , Constantin Virgil , Donath Cristina , Yanushkevich Kazimir , Zhivulka Aliona , Galyas Anatholy , Demidenko Olga , Popescu Ana Maria
Published: February 2020

The corrosion behaviour of special steels (OL44, OL52, SS1.4571) exposed to choline chloride (ChCl) based ionic liquids, has been investigated by polarization curves method at 80�C. Micrographic images before and after corrosion were obtained. The corresponding corrosion parameters in ChCl-Oxalic acid and ChCl-Malonic acid were calculated. The crystal structure was studied before and after the corrosion process by using X-ray diffraction method. The specific magnetization was investigated by ponderomotive method.
Estimation of the Combustion Temperature Profile in a Romanian Oil Field
Authors: Branoiu Gheorghe , Cristescu Tudora , Nistor Iulian
Published: February 2020

Developing and producing of the heavy crude oil involved significant economic and technological challenges. The oil industry ability to prospect and capitalize the huge world heavy oil resources both economically and environmentally friendly will be crucial in helping meet future energy needs. Thermal oil recovery is one of the three types of techniques belonging to Enhanced Oil Recovery. It is applied for increasing the cumulative of crude oil that can be produced in an oil field. One of the oldest thermal oil recovery is in-situ combustion or fireflooding applied for the first time about 100 years ago. Despite in-situ combustion has not found widespread acceptance among operators like other thermal processes (such as steam injection), analysis of the successful projects indicates that the process is applicable to a wide range of oil reservoirs, especially to heavy crude oils. An important monitoring parameter of thermal oil recovery process is represented by thermal regime especially in heavy oil fields in which a high-temperature regime must be occur as the in-situ combustion to be successful. In the paper the authors are using thermal analysis (thermogravimetric and thermodifferential analysis) for investigation of the thermal regime involved in the production process of an oil reservoir by in-situ combustion.
Physicochemical Quality Evolution of Groundwater from the Area of an Chemical Platform
Authors: Popescu Luisa Roxana , Dinu Cristina
Published: February 2020

The most important natural resource which cannot be optimally used and sustained unless its quality is properly assessed, is groundwater. In the present study, the physicochemical variations of groundwater from the area of an chemical platform were determinate. The physicochemical parameters determined for the groundwater were evaluated by comparing the results obtained with the the limits allowed under current legislation. For this study were examining 16 drillings for a period of five years. Water samples were collected quarterly from each sampling point in the study. The physico-chemical quality indicators analyzed for each source were: pH, chlorides, sulfates, bicarbonates, carbonates, sodium, calcium, magnesium, ammonium, filterable residue, suspended matter, mercury and CCO-Mn.Interpretation of physicochemical data revealed that groundwaters studied was neutral to slightly alkaline. The cations such as sodium (Na+) for all groundwaters studied it was in general found above the limit imposed under the laws in vigor in almost all studied drillings except drillings generally located upstream of the industrial platform. The anions such as chlorides (Cl-) exceeded, in general, the limit allowed under current legislation. The filterable residue concentration was observed in all the studied drillings and the parameter such as sulfate (SO42-), were within the limit allowed under current legislation for the most all studied drillings, for the whole period investigated. In general, the sulfate quality indicator exceeds the required limit, for drilling located downstream and in vicinity of the chemical platform.
Chemical Ablation in Adenoid Surgery
Authors: Ghindea Teodora Ioana , Meius Alexandru Dumitras , Stefanescu Dragos Cristian , Pietrosanu Catalina , Ionita Irina , Suceveanu Andra Iulia , Rusescu Andreea , Zainea Viorel , Hainarosie Razvan
Published: February 2020

The pharyngeal tonsil is a lymphatic tissue mass located in the roof of the nasopharynx. The function of the pharyngeal tonsil is to prevent infections with the help of antibodies. Chronic inflammation and allergies lead to hyperplasia of the adenoids that is found almost exclusively in children. The treatment of choice is surgical treatment; conservative treatment is only indicated preoperatively or if surgery is contraindicated. In this paper, we will present a new surgical method for adenoidectomy performed trans-orally with coblation, under endoscopic control.
Blood Parathyrin and Mineral Metabolism Dynamics. A clinical analyze
Authors: Radu Lucretiu , Carsote Mara , Gheorghisan Galateanu Ancuta Augustina , Preda Smaranda Adelina , Calborean Veronica , Stanescu Radu , Gheorman Victor , Albulescu Dana Maria
Published: February 2020

Circulating parathyrin (PTH or parthormon) is increased in primary hyperparathyroidism (PHP) in association with high total/ionic calcium (T/I Ca) and others mineral metabolism anomalies. This is a clinical cross-sectional and case-control study analyzing these changes after PHP surgical correction in menopausal women. Baseline parameters were: mean age at diagnosis (59.63�9.6 years), TCa of 10.9�0.7 mg/dL, PTH of 138.02�59.36 pg/mL. Longitudinal data showed: final TCa p[0.00001, ICa p[0.00001, phosphorus p[0.0001, magnesium p=0.9, 24-h urinary calcium p=0.4, 25-hydroxycholecalciferol p=0.01, PTH p[0.00001. High circulating parathyrin values due to PHP normalized after surgery in addition to statistical significant changes of TCa, ICa, P, lumbar Bone Mineral Density provided by Dual-Energy X-Ray Absorptiometry; Mg and 24-h Ca might not be a marker of general mineral metabolism improvement.
The Role of the Cognitive Behavioral Therapeutic Intervention in the Social-professional Reintegration of the Unemployed People
Authors: Bordea Elena Nicoleta , Pellegrini Angelo
Published: February 2020

The unemployment, especially the repeated and long-term unemployment, can cause in time, stress vulnerability, negative cognition regarding to oneself, world and future. The distructive consequences of the unemployment lend quite well, as a form of therapeutic intervention, to a cognitive behavioral approach which has the purpose of a faster social and occupational reintegration and the increase of the life quality of the unemployed persons. The objective was to prove the positive influence of the cognitive behavioral therapeutic intervention regarding the level of social-professional reintegration of the unemployed. Participants included in the survey were 432 people (224 women and 208 men) from the urban area, being unemployed, selected using the method of simple random sampling, divided through stratified randomization in two groups. A cognitive behavioral therapeutic intervention was applied to the experimental group and no therapeutic intervention was applied to the witnessing group. It has been observed that there are significant differences between the initial unemployment condition and the final unemployment condition, in which a part of the unemployed were reintegrated socially-professionally after 6 months after the cognitive behavioral therapeutic intervention. The experimental group (to which therapy was applied) experienced a reintegration degree double (36.57%) comparing to the witnessing group (19.44%) where no therapeutic intervention was performed. The cognitive behavioral therapeutic intervention increased the degree of the social-professional reintegration of the unemployed.
PCR Technique Assisting the Early Diagnosis of Human Papillomavirus A retrospective clinical study
Authors: Mensch Karoly , Szarka Krisztina , Mensch Henrik , Dobai Adrienn , Magyar Zoltan , Pacurar Mariana , Vartolomei Aurel Claudiu , Manuc Daniela , Nagy Csaba Dobo
Published: February 2020

The number of oral cancers associated with Human Papillomavirus (HPV) infection is increasing worldwide. The purpose of this retrospective clinical trial is to investigate the relationship between genital and oral HPV infection and to observe the possibilities of polymerase chain reaction (PCR) technique and the limitations for oral HPV infection. The results of genital and oral HPV screening of 34 female patients and their partner, and 14 single female patients were processed in a private practice in Budapest between 2012 and 2015. After brush-biopsy sampling, HPV DNA identification and typing were performed using PCR technique. All in all 164 samples were typed. HPV DNA was detected in 76 cases (48.20%). HPV was detected in 55 cases from the genital samples (67%), and in 21 cases from the oral samples (25.6%). Genital HPV infection was statistically significantly higher in women (79.2% vs 22,9%, p[0.001). Gender comparison of genital HPV infection showed a statistically significant difference (79.2% for women, 50% for men, p = 0.006). In case of genital HPV infection, the oral HPV infection of the same person is more frequent. In this study, the above mentioned difference is significant for women and not significant for men. HPV16 is the HPV genotype which was identified in the highest ratio(47.2%). PCR technique is capable of the detection of oral HPV infection, but follow-up studies with higher case number , and questionnaire studies are needed to understand HPV transmission more accurately.
Optimization and Numerical Anlysis of Mechanical Properties of Connecting Rod in the Internal Combustion Engine
Authors: Sliwa Agata , Gros Dariusz , Sandu Andrei Victor , Nabialek Marcin
Published: February 2020

The paper presents the process of optimisation of geometry of connecting rod used in the automotive industry. This connecting rod is used in a sports car with a high power engine, where high torque values can damage individual components. Three numerical, geometric models of 40HNMA structural steel connecting rods were made for optimisation. Statistical analysis of strength properties using the finite element method was carried out, and results for the models were compared. The simulation and calculations were performed in SolidWorks.
Gut Microbiota and Serotonin - Biochemical Pathways in Age-Related Macular Disease
Authors: Danca Cristina , Costea Claudia Florida , Costan Victor Vlad , Turliuc Mihaela Dana , Sava Anca , Turliuc Serban , Cucu Andrei , Dragomir Raluca Alina , Sadiye Scripcariu Ioana , Dumitrescu Nicoleta , Carauleanu Alexandru
Published: February 2020

Age-related macular degeneration (AMD) is a multifactorial disease and is a major cause of blindness in the entire world. Current studies show a tight connection between gut microbiota and AMD. This literature review shows the positive role played by gut microbiota, which is essential in providing the optimal serotonin level in retina protection against the noxious action of various factors of the environment. Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter derived from tryptophan which is poorly expressed in the retina, but it may provide protection against retinal damage, such as light-induced retinopathy and age-related macular degeneration, due to the fact that certain serotonin receptor agonists and antagonists of those 7 classes and 17 subtypes of 5-HT receptors help prevent serum deprivation, anoxia and oxidative damage. Our study also shows the role played by other diet-related factors, which protect retina against oxidative stress and delay the onset of AMD.
The Influence of Parameters of Heat Treatment on Thickens and Roughness of Oxide Layers on Titanium Alloy Ti6Al4V
Authors: Szota Michal , Lukaszewicz Adrian , Kosinski Konrad
Published: February 2020

The paper presents the affect of temperature and time of annealing on the thickness of the obtained oxide layer on the surface of titanium alloy Ti6Al4V and also on the geometry of the layer. The studies on seven samples where they were determined from 1 to 7 were carried out. Sample 1 was a reference sample of material that was subjected to the following parameters: for the sample 2 the temperature 350 �C in 5 hours, for the samples 3 and 4 450 �C and in sequence 1 and 10 hours, for the sample 5 and 6 550 �C and in sequence 1 and 10 hours and for the sample 7 temperature 650 �C in 5 hours. Studies have shown that thicker oxide layers with less surface development form on samples occurred after longer heat treatment and higher temperatures. Thanks to these dependencies it is possible to maneuver the time and temperature of the treatment interchangeably, eg. by raising the temperature of annealing time can be shortened to obtain similar parameters of the roughness profile as for the sample processed at a lower temperature in a longer time.
Simple Real-time Voltammetric Method for Captopril Determination
in Pharmaceutical Formulation
Authors: Buleandra Mihaela , Ciucu Anton Alexandru , Stefanescu Dragos Cristian
Published: February 2020

A novel voltammetric assay for captopril (CAP) determination by using an electrochemically pretreated pencil graphite electrode (PGE*) is presented. The electrochemical oxidation reaction of CAP was investigated with PGE* by using cyclic voltammetry and linear sweep voltammetry techniques. CAP was electrochemically inactive at the non-pretreated pencil graphite electrode surface, while a sharp anodic wave with an anodic peak potential at around 200 mV resulted by using the PGE*. According to kinetic studies upon the electrode behavior, a new reaction mechanism for electrochemical oxidation of captopril is proposed. The sensor was examined as a selective, simple and precise new electrochemical disposable electrode for the determination of CAP in pharmaceutical samples in complex medical cases associated with sleep apnea, with good results.
The Effects of the Therapeutic Regimen Used in Hodgkin Lymphoma and the Correlation with Prognosis Factors
Authors: Pescaru Monica , Potre Oncu Ovidiu , Bucur Adina Ioana , Ionita Hortensia , Popovici Ramona Amina , Rusu Laura Cristina , Oncu Cristina Potre
Published: February 2020

The Hodgkin lymphoma treatment is adapted to the disease type, disease stage and to an evaluation of the risk. The treatment is focused on the adjustment of the therapy to each patient depending on the age, toxicity risk on short and long term and the relapse risk. The study proposes the evaluation of the response to the treatment further to the administration of different therapeutic regimens as well as the correlation with the negative diagnosis factors of Hodgkin lymphoma. This is a retrospective study on 71 patients diagnosed with Hodgkin lymphoma in the Hematology Department of Timisoara between January 2014 and December 2017. The data obtained have been collected from a database and processed with the SPSS 20.0. software . In our study there were included 71 patients diagnosed with Hodgkin lymphoma with a medium age of 42.12�16.45 years old. By the time of the diagnosis, the patients showed the following hematological, biochemical and immunological parameters. The response to treatment is influenced by the presence of the negative prognosis factors : the age of �40 years old, extralymphatic infiltration, VSH ] 50mm/h , presence of general B signs, more than 3 lymph node sites affected, bulky disease and Ann-Arbor III and IV stages. The treatment of Hodgkin lymphoma is guided by the traditional clinic prognostic factors and by the laboratory which often represent a substitute marker for the biological characteristics which many times are not included in the standard evaluation.
Serum Concentration of hsCRP - Possible Marker for Therapy Evaluation in Left Ventricular Dysfunction with Preserved Ejection Fraction
Authors: Coculescu Bogdan Ioan , Dinca Gabi Valeriu , Manole Gheorghe , Purcarea Victor Lorin , Oproiu Ana Maria , Stocheci Cristina Mariana
Published: February 2020

The study on a subset of 208 patients with diastolic dysfunction with the ejection fraction preserved discusses the possibility of circulating CRP levels to be accepted as a diagnostic marker. In order to carry out a comparative analysis of the significance of hsCRP serum values, the study also included a subgroup labeled as control, consisting of the same number of patients, but diagnosed only with painful chronic ischemic cardiopathy - a stable form of angina pectoris. The conclusion of the study is that the circulating level of hs-CRP can be accepted as a diagnostic marker for both ischemic cardiopathy and diastolic dysfunction with preserved ejection fraction. The result, corroborated with data from other studies that recognize the serum concentration of hs-CRP as a predictor marker in cardiovascular disease, supports its usefulness as a marker for cardiac insufficiency with a history of ischemic cardiopathy, without being a marker for assessing the degree of myocardial contractility deficiency.
The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data
Authors: Buca Beatrice Rozalina , Mititelu Tartau Liliana , Rezus Ciprian , Filip Cristiana , Pinzariu Alin Constantin , Rezus Elena , Popa Gratiela Eliza , Panainte Alina , Lupusoru Catalina Elena , Bogdan Maria , Pavel Liliana , Lupusoru Raoul Vasile
Published: February 2020

We aimed to investigate the effects of two nitric oxide donors in acute inflammation in rats. The experiment was carried out on white Wistar rats, randomly distributed in 4 groups of 5 animals each; the substances were administered intraperitoneally as follows: Group 1 (SS): saline solution 0.1mL/100 g body weight (control); Group 2 (IND): indometacin 150 mg/kg body weight; Group 3 (NEB): nebivolol 1 mg/kg body weight; Group 4 (GSNO): S-nitroso-glutathione 1 mg/kg body weight. An experimental model of acute hind paw inflammation with carrageenan was used for the researches. The influence of the nitric oxide donors on blood parameters, specific inflammatory and immune markers was evaluated 24 h, respectively 72 hours after the injection of irritant agent. The experimental protocol was implemented according to the recommendations of our University Committee for Research and Ethical Issues. The administration of nitric oxide donors nebivolol and S-nitroso-glutathione was accompanied by a substantial diminution of paw edema, as well as by an important decrease in the percent of lymphocytes, a reduction of interleukin 6 and tumor necrosis factor alpha values. The effects of nebivolol were more accentuated than of S-nitroso-glutathione, but less intense than of indomethacin in the experiment. The treatment with nebivolol and S-nitroso-glutathione produced anti-inflammatory effects on local acute inflammation in the carrageenan-induced paw edema test in rats.
Optimization of Waste Inertization Systems Based on Chemically Bonded Phosphate Ceramics
Authors: Dumitrescu Elena , Andronescu Ecaterina , Mares Alina Monica
Published: February 2020

This paper presents the experimental results for optimization of the waste inertization systems based on Chemically Bonded Phosphate Ceramics (CBPCs). Through this process, the hazardous wastes containing heavy metals are transformed, by chemical reactions and binding in a solid matrix, into non-hazardous wastes. It was studied the obtaining mode of chemically bonded phosphate ceramics from magnesium oxide and potassium dihydrogen phosphate. Since the CBPCs system is a fast setting system it was studied the effect of retarders (boric acid and calcium lignosulphonate) used in concentrations of 1, 2 and 3% (based on the amount of magnesium oxide and potassium dihydrogen phosphate) above the setting process. It was determined the setting time and compressive strength of the obtained samples. The optimal variant has been established to obtain a suitable material in terms of both mechanical and compositional properties.
Study Regarding the Serum Level of Uric Acid and the Metabolic Syndrome
Authors: Velimirovici Dana Emilia , Rada Maria , Vaduva Delia Mira Berceanu , Velimirovici Milan Daniel , Dragan Simona , Seiman Daniel Marius Duda , Cipu Daniela , Seiman Corina Duda , Stancu Adrian , Berceanu Vaduva Marcel Mihai
Published: February 2020

The goal of this study is to investigate the relationship between the serum level of uric acid (UA) and metabolic syndrome (MetS) according to age and gender. The study included 395 patients (200 women and 195 men), with a mean age of 53.6�18 years. Hyperucemia (HU) was defined by a serum level UA �7mg/dL in men and � 6mg/dL in women (according to the EULAR guide), and MetS was defined according to the criteria of the International Diabetes Federation (IDF). The prevalence of hyperuricemia in the study lot was 17.21%, and MetS was 35.44%. In women, the prevalence of HU and MetS increases with age: 13.88% of women over 65 years show HU, and 44.44% of them comprise the elements of MetS. In men, HU and MetS do not vary significantly depending on age. MetS has a higher prevalence in HU patients than in HU-free patients. HU prevalence in MetS patients was 32.65% in women versus 46.15% in men. In conclusions, the prevalence of HU and MetS differs significantly according to gender and age. The prevalence of MetS was higher in male subjects of medium age and HU did not vary significantly depending on age. In women, the prevalence of HU and MetS was higher in those over 65 years. Hyperuricemia in middle-aged female patients can predict the MetS development.
Comparison of the Fatty Acid Composition of Peanut Butter by Applying Different Fat Extraction Procedures
Authors: Negoita Mioara , Mihai Adriana Laura , Adascalului Alina , Iorga Enuta , Belc Nastasia
Published: February 2020

The aim of this work was to evaluate the influence of different fat extraction procedures on the fatty acids composition (FAs) of a NIST standard reference material, peanut butter (SRM�2387). Extraction of fat was made with petroleum ether by applying six extraction procedures: Soxhlet automatic with B�chi B-811 unit: Soxhlet standard (SS); Soxhlet warm (SW); Hot extraction (HE) and Continuous flow (CF), repeated extraction with solvent (SR) and Soxhlet traditional extraction (ST), by using a Soxhlet extractor. Identification of FAMEs was based on retention time (RT) and the ratio of characteristic ions (m/z) of the reference standards F.A.M.E. Mix C4-C24 and SRM�2377. FAMEs determination was realized by using internal standards (IS) and applying relative response factors (RRFi), and without IS by applying correction factors (Fi). Determination of FAMEs was performed on a GC-MS. Triglyceride of pentadecanoic acid (TAG-IS C15:0) was used as an IS to assess the analyte losses during FAMEs preparation steps, and tricosanoic acid methyl ester (FAME-IS C23:0) was used to evaluate the analyte losses on GC injection. Values of fat content and fatty acids composition determined by the 6 extraction procedures were compared with the NIST certified values of SRM�2387. All 4 procedures of extraction made with B�chi unit B-811 were effective in fat extraction and analysis of fatty acids composition compared to standard methods. Between the experimentally determined values and the certified values there were no significant differences.
Aniline Derived Bis-Schiff Base - Analytical Reagent for the Assay of Fe (III)
Authors: Tantaru Gladiola , Bibire Nela , Panainte Alina Diana , Vieriu Madalina , Apostu Mihai
Published: February 2020

A new spectrophotometric method for the quantitative determination of Fe (III) was established based on the complexation reaction with a new bis-Schiff base, 4,4`-methylenebis-salicylidene aniline, when a stable complex with an absorption maximum at 520 nm was obtained. The conditions of the complexation reaction were established and the method was validated according to ICH guidelines in terms of linearity, accuracy, precision of the method and the limits of detection and quantification were determined. The method was applied with good results for the quantitative determination of Fe (III) in pharmaceutical products.
Diabetic Nephropathy: a Concise Assessment of the Causes, Risk Factors and Implications in Diabetic Patients
Authors: Balcangiu Stroescu Andra Elena , Tanasescu Maria Daniela , Diaconescu Alexandru , Raducu Laura , Balan Daniela Gabriela , Mihai Andrada , Tanase Mihaela , Stanescu Iulia Ioana , Ionescu Dorin
Published: February 2020

Due to the increasing number of patients in recent years, diabetes represents one of the major medical concerns. This is owed to the meaningful impact this disease has on patients� quality of life and secondary to its complications over patient survival. Diabetic nephropathy epitomises one of the complications in these patients and plays a significant role in establishing their life expectancy.
Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss
Authors: Erdelean Dragos , Farcas Simona Sorina , Poroch Vladimir , Andreescu Nicoleta Ioana , Erdelean Izabella , Dobrescu Andreea Iulia , Nussbaum Laura Alexandra , Hogea Lavinia Maria , Navolan Dan , Tutac Paul , Puiu Maria
Published: February 2020

Spontaneous miscarriage is reported in approximately 15% of the clinically recognized pregnancies. Several reports have showed an increased risk of miscarriage in patients with thrombophilia, but due to the heterogeneity of study design the role thrombophilic factors and the use of anticoagulant therapy in prevention of pregnancy loss is still unclear. The current study includes 55 patients for which we ran a screening of the most commonly inherited thrombophilia mutations (FVL, FII, MTHFR C677T/A1298, PAI 4G/5G mutations). We found that most of the patients (92.72%) associated mutation in at least 2 of the genes evaluated. Only a small number of patients (7.27%) had a single variant identified. We have found high prevalence of the studied variants in the pregnant patients that experience pregnancy loss, with risk allele frequencies increased from 2 to 11 times as compared to the general population. We consider that evaluation of the trombophilic variants should be indicated for patients with pregnancy loss in order to establish a possible cause for the miscarriage.
Elaboration of Ti-based Biocompatible Alloys Using Nb, Fe and Zr as Alloying Elements
Authors: Pantilimon Cristian , Coman George , Gradinaru Catalin , Tarcea Claudia , Ciuca Sorin , Sohaciu Mirela , Berbecaru Andrei , Matei Ecaterina , Predescu Andra , Predescu Cristian
Published: February 2020

Increasing biocompatibility of implant materials is an important factor in developing better and long-lasting implants that function in a very close way to real tissue and bone. Various alloys have been chosen due to their biocompatibility, such as: stainless steels, titanium alloys and nickel or cobalt alloys. According to the alloying elements it is possible to change the material properties to fit into various application niches such as pacemaker devices, stents, biosensors, dental or bone implants and others. Some alloying elements confer higher biocompatibility than others and the commonly used alloys include elements that can be detrimental to human health such as Nickel, Vanadium and Cobalt. Choosing alloying elements such as Nb, Fe and Zr in order to replace the commonly used metals reduces the risks of accumulation of various substances that can damage the human tissues and lead to health complications. The proposed alloys are elaborated in a Five Celes melting furnace under argon atmosphere in order to create a more homogeneous material with lesser defects and inclusions. The cast alloys are then analyzed through modern methods such as SEM, XRD, EDS and their mechanical properties such as hardness and strength and these properties are compared to that of the bone in order to assess mechanical reliability.
Possible Pathway for Ifosfamide Degradation via Fe-TiO2 Assisted Photo Catalysis
Authors: Constantin Lucian Alexandru , Constantin Mirela Alina , Nitoi Ines , Chiriac Florentina Laura , Galaon Toma , Cristea Nicolae Ionut
Published: February 2020

Ifosfamide (IF) degradation from aqueous system via UV-Vis Fe-TiO2 system was studied for a photo catalyst dose of 200 mg/L and an irradiation time up to 240 min. IF degradation efficiency was monitored via Liquid Chromatography-Mass Spectrometry technique (LC-MS). Experimental photocatalytic tests were performed both in the absence and presence of 2-propanol and F- radicals� scavengers and the results proved that IF degradation occurs most likely in the bulk solution. Experimental results showed that degradation efficiencies for IF varied between 39.52% in the presence of 2-propanol and 70.70% in the scavengers� absence. Six degradation intermediates were identified using the same LC-MS technique and a three stage degradation pathway was proposed based on both available literature data and evolution of degradation intermediates peaks.
Functional Results of Different Repair Techniques for Knee Articular Cartilage Lesions
Authors: Bardas Ciprian Alin , Zsolt Gabri Jozsef , Apostu Dragos , Dan Daniel Oltean , Tomoaia Gheorghe , Benea Horea Rares Ciprian
Published: February 2020

The articular cartilage lesions are frequent and highly affect the patient�s quality of life. Although remarkable progress in the treatment of focal lesions of articular cartilage were lately made, controversies still exist regarding the treatment options. The main purpose of this study was to evaluate and compare the preoperative and 6 months postoperative knee functional scores of patients undergoing arthroscopic repair of knee chondral lesions by: debridement, microfractures, osteochondral autograft transplantation and autologous matrix-induced chondrogenesis. Chondral reconstruction with collagen membranes and osteochondral autograft transplantation techniques showed a superior result at 6 months postoperatively compared to microfracture techniques and mechanical debridement.
Preoperative Hemoglobin Dynamics in Patients with Trochanteric Fractures. A multivariate analysis
Authors: Gheorghevici Teodor Stefan , Veliceasa Bogdan , Puha Bogdan , Toader Stefan , Alexa Ioana Dana , Alexa Ovidiu
Published: February 2020

Preoperative anemia is a common finding among geriatric patients with trochanteric fractures. We assessed the dynamics of hemoglobin and the factors that influence it. A total of 780 patients with trochanteric fractures were selected. Distribution by gender showed a slightly higher proportion of female patients (64.1%). The preoperative interval ranged from a few hours to 19 days. Hospital admission period varied from 1 to 49 days. Hemoglobin ranged from 4.80 to 17.40 g/dl; 43.1% of patients had individual values below the baseline. Individually, the hemoglobin value varied from a decrease of 9.33 g/dL to an increase of 11.97 g/dL, but the total study group recorded an average decrease of 0.96 � 1.75 g/dL. Hemoglobin had a downward trend directly correlated with the preoperative interval period. Decrease in hemoglobin was correlated with the percentage of blood lymphocytes, PLT/WBC ratio, prothrombin activity and APTT ratio. A low level of hemoglobin variation was associated with a shorter preoperative interval, reduced prothrombin time, prothrombin activity ] 100, INR ] 1.50 and APTT ] 30.
Assessing Factors that Influence the Level of Glycated Hemoglobin in Children and Adolescents with Type 1 Diabetes
Authors: Puiu Ileana , Dan Alexandra Oltea , Tartea Elena Anca , Rogoveanu Otilia Constantina , Bica Elena Catalina , Dinescu Sorin Nicolae , Vasile Ramona Constantina , Dinescu Venera Cristina , Romanescu Florin Marius , Tudorascu Diana Rodica
Published: February 2020

The aim of our study was to assess the factors that influence the level of glycated hemoglobin in children and adolescents with type 1 diabetes (T1D). This study included 122 children and adolescents suffering from T1D who were in the evidence of the First Pediatric Clinic of the Clinical Emergency County Hospital of Craiova between 2003 and 2017. If HbA1c was less than 7.50%, we included patients in the glycemic equilibrium group, and if HbA1c was greater than 7.50%, we considered patients as suffering from unbalanced diabetes. By correlating the glycosylated hemoglobin level with the different parameters used in the study, we observed large/strong positive correlations between HbA1c and duration of diabetes mellitus and also between HbA1c and patient age, HbA1c negative correlation between physical activity, medium/moderate positive correlations between HbA1c and body mass index, weight of the patients and daily insulin dose and the height of the patients included in the study did not show significant correlations. Child and adolescent diabetes management has major adult differences in both insulin and drug treatment, in general, but especially in the need of understanding, counseling and integration specific to these ages.
Synthesis and Characterization of a Core-shell Material Using YBa2Cu3O7-d and Cobalt Ferrite Nanoparticles
Authors: Colie Maria , Mihaiescu Dan Eduard , Istrati Daniela , Surdu Adrian Vasile , Vasile Bogdan , Stanica Nicolae , Fudulu Adrian , Andronescu Ecaterina
Published: February 2020

In this paper we describe the synthesis of a core-shell material using yttrium superconducting ceramic material (YBCO) and cobalt ferrite nanoparticles in order to obtain a nanostructured material with magnetic properties. The advantages of such material aim the selective deposition of nanofilms oriented in magnetic fields. To obtain this core-shell material, the solutions of the nitrates were first obtained by dissolving the salts in demineralised water. The suspension with cobalt ferrite nanoparticles was obtained by co-precipitation method. To obtain YBa2Cu3O7-�- coated magnetic nanoparticles by autocombustion reaction the solutions of nitrates and citric acid were used. The ratio of the metal ions: Y:Ba:Cu was 1:2:3, and between the oxidant and the reducing agent was used a citrate / nitrate mass ratio equal with 0.7. The final material was analyzed by X-ray diffraction (XRD), electronic scanning microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), high resolution transmission electron microscopy (HRTEM) and vibrating sample magnetometer (VSM).
Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers
Authors: Tanase Constantin , Udeanu Denisa Ioana , Draghici Constantin , Cocu Florea
Published: February 2020

1-Ethylamide-, 1-ethanolamide of D-Cloprostenol and their 15-epi-isomers were synthesized by amidation of methyl esters of D-Cloprostenol or 15-epi-Cloprostenol. The crude compounds were purified by pressure chromatography on silica gel and fully characterized by IR, 1H-, 13C-, 2D-NMR (COSY and HETCOR) and MS spectroscopy.
In silico Evaluation of the Antiproliferative Mithocondrial Targeted Mechanism of Action of Some Pentacyclic Triterpene Derivatives
Authors: Macasoi Ioana , Mioc Marius , Berceanu Vaduva Delia , Ghiulai Roxana , Mioc Alexandra , Soica Codruta , Muntean Danina , Dumitrascu Victor
Published: February 2020

Mitochondria play an important role in regulating cell viability. Mitochondrial dysfunction has been associated with many known pathologies including cancer. Mitocans are a class of compounds that alter important mitochondrial functions in cancer cells thus inducing cellular death. New pentacyclic triterpene derivatives are constantly developed with the aim of obtaining highly active antiproliferative agents. In this study a set of previously synthesized rhodamine B triterpene conjugates, designed as mitocans, were in silico evaluated with the purpose of elucidating their targeted mithocondrial mechanism of action. Molecular docking revealed that the compounds would predominantly interact with proteins that are part of the mithocondrial electron transport chain (ETC), such as NAD(P)H-quinone oxidoreductase (NDH) and succinate dehydrogenase (SDH).
Band GAP Frequency Response in Regular Phononic Crystals
Authors: Garus Sebastian , Szota Michal
Published: February 2020

The study investigated the propagation of a mechanical wave in a two-dimensional phononic structure. The influence of material from which metaatom rods were made on the phononical properties of the structure was investigated. Rods made of amorphous Zr55Cu30Ni5Al10 and polypropylenes were compared. The Finite Difference Time Domain (FDTD) algorithm was used to carry out the simulation. Next, theoretical and experimental analysis of the intensity of the mechanical wave was carried out. Frequency response of a regular phononic structure was also analyzed.
Hydrothermal Synthesis and Characterization of Hybrid ZnO/3D Graphene Structures
Authors: Chitanu Elena , Banciu Cristina , Sbarcea Gabriela , Marinescu Virgil , Bara Adela , Barbu (Prioteasa) Paula
Published: February 2020

In this paper we obtained hybrid ZnO/3D graphene structures through hydrothermal growth of ZnO nanoparticles on 3D graphene substrate obtained by chemical vapour deposition (CVD) method in order to use them as electrode in solar cells. The influence of hydrothermal process parameters on structural and morphological properties of the obtained ZnO nanoparticles was studied. The temperature and the duration of the process had an important influence on the ZnO nanostructures obtaining.
Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics
Authors: Mateescu Mariana , Doncea Sanda Maria , Raut Iuliana , Nistor Cristina Lavinia , Bujanca Ioneta Codrina
Published: February 2020

The hydroxyapatite (HA) nano and microparticles were synthesized by wet-chemical precipitation in order to use them as drug carriers for biomedical applications. Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR) were performed to assess their size, external morphology and chemical composition. The properties of HA particles as drug carriers for antibiotics delivery were evaluated with doxycycline and chloramphenicol. The amount of drug loading and release was determined by UV-Visible spectrophotometry. The antibacterial properties of loaded HA particles were evaluated using gram-positive Bacillus subtilis bacteria and gram-negative Pseudomonas aeruginosa bacteria. The synthesized particles of HA exhibit a high adsorption capacity (around 99%) and good controlled release properties for doxycycline. The adsorption of chloramphenicol on HA was extremely low (about 2%). According to the results, the compatibility between the drug and substrate is an important factor in the absorption process, and the hydroxyapatite is a very promising carrier for controlled release of antibiotics.