bluuebunny/crossref_metadata_2025 huggingface dataset:
Racial and Ethnic Disparities in Health Outcomes Among Long-Term Survivors of Childhood Cancer: A Scoping Review
Authors: Reeves Tegan J. , Mathis Taylor J. , Bauer Hailey E. , Hudson Melissa M. , Robison Leslie L. , Wang Zhaoming , Baker Justin N. , Huang I-Chan
Published: October 2021

The five-year survival rate of childhood cancer has increased substantially over the past 50 yr; however, racial/ethnic disparities in health outcomes of survival have not been systematically reviewed. This scoping review summarized health disparities between racial/ethnic minorities (specifically non-Hispanic Black and Hispanic) and non-Hispanic White childhood cancer survivors, and elucidated factors that may explain disparities in health outcomes. We used the terms “race”, “ethnicity”, “childhood cancer”, “pediatric cancer”, and “survivor” to search the title and abstract for the articles published in PubMed and Scopus from inception to February 2021. After removing duplicates, 189 articles were screened, and 23 empirical articles were included in this review study. All study populations were from North America, and the mean distribution of race/ethnicity was 6.9% for non-Hispanic Black and 4.5% for Hispanic. Health outcomes were categorized as healthcare utilization, patient-reported outcomes, chronic health conditions, and survival status. We found robust evidence of racial/ethnic disparities over four domains of health outcomes. However, health disparities were explained by clinical factors (e.g., diagnosis, treatment), demographic (e.g., age, sex), individual-level socioeconomic status (SES; e.g., educational attainment, personal income, health insurance coverage), family-level SES (e.g., family income, parent educational attainment), neighborhood-level SES (e.g., geographic location), and lifestyle health risk (e.g., cardiovascular risk) in some but not all articles. We discuss the importance of collecting comprehensive social determinants of racial/ethnic disparities inclusive of individual-level, family-level, and neighborhood-level SES. We suggest integrating these variables into healthcare systems (e.g., electronic health records), and utilizing information technology and analytics to better understand the disparity gap for racial/ethnic minorities of childhood cancer survivors. Furthermore, we suggest national and local efforts to close the gap through improving health insurance access, education and transportation aid, racial-culture-specific social learning interventions, and diversity informed training.
Investigating the Relationships Between Public Health Literacy and Public Trust in Physicians in China's Control of COVID-19: A Cross-Sectional Study
Authors: Chen Dongjin , Zhou Qian , Pratt Cornelius B. , Su Zhenhua , Gu Zheng
Published: October 2021

Objective: Public trust in physicians and public health literacy (HL) are important factors that ensure the effectiveness of health-care delivery, particularly that provided during the SARS-CoV-2 pandemic. This study investigates HL as a predictor of public trust in physicians in China's ongoing efforts to control COVID-19.

Methods: Data were gathered in February 2020 during the peak of the disease in China. Based on Nutbeam's conceptualization of HL, we measure HL vis-à-vis COVID-19 by using a six-item scale that includes two items each for functional, interactive, and critical HL. Trust in physicians was measured by assessing physicians' capability to diagnose COVID-19. A rank-sum test and ordinal logit regression modeling were used to analyze the data.

Results: Two key findings: (a) trust in physician handling of treatment for COVID-19 is reported by about 74% of respondents; and (b) five of the six HL measures are positive predictors of public trust in physician treatment of the disease, with functional HL1 having the highest level of such association (coefficient 0.285, odds ratio 1.33%, p < 0.01).

Conclusions: Improving public HL is important for better public-physician relationships, as well as for nations' efforts to contain the pandemic, serving as a possible behavioral, non-clinical antidote to COVID-19. Being confronted with the unprecedented virus, humans need trust. Health education and risk communication can improve public compliance with physicians' requirements and build a solid foundation for collective responses.
Focused Research on the Challenges and Productivity of Researchers in Nigerian Academic Institutions Without Funding
Authors: Igiri Bernard E. , Okoduwa Stanley I. R. , Akabuogu Ebere P. , Okoduwa Ugochi J. , Enang Idongesit A. , Idowu Olanipekun O. , Abdullahi Suleiman , Onukak Imeh E. , Onuruka Catherine C. , Christopher Ogechukwu P.O. , Salawu Akinbobola O. , Chris Aimee O. , Onyemachi David I.
Published: October 2021

Background: The challenge of research funding constraints has brought to bear enormous pressure on researchers. Research productivity is relevant to prestige and career progression of academic staff. However, this study aimed to explore significant challenges associated with researchers’ productivity and the impact of non-funding of research in Nigerian research and tertiary institutions.

Methods: This study adopted a qualitative exploratory design involving academics at various research and tertiary institutions across the six geographical regions in Nigeria. A semi-structured questionnaire was distributed electronically to all participants who consented to take part in this study. Exactly 4,159 questionnaires were administered and 2,350 were completely filled and returned. Pearson correlation matrices with logistic regression were used for data analysis and are presented in frequencies and percentages.

Results: On challenges faced by respondents, 42.98% reported a lack of research funding, 17.11% mentioned brain drain challenge while 8.85% indicated a lack of motivation. Of the 23,927 publications reported, the number of those in sciences, engineering, and medical sciences averaged 9.6, 11.5, and 9.5 respectively. The average number of publications by women (10.8) was more than by men (9.7). Lecturers had the highest average research publication number (11.8) followed by researchers (10.2) and others (3.9). Men had the highest (11.9) average number of conferences compared to women (9.2). Participants in engineering had an average number of 13.8 conferences per respondents followed by those in education (11.2), sciences (11.1), and 10.9 for those in agricultural sciences. The result revealed a negative significant correlation between research publication and academic qualification at p < 0.01. Positive significant correlation was observed between research productivity and discipline at p < 0.05. Findings show that the combined influence of the independent variables on research productivity was significant using linear regression analysis.

Conclusions: The failure to prioritize research has resulted in underdevelopment in Nigeria. It is therefore imperative that the federal government prioritize research and establish a functional Special Research Trust Fund to oversee research funding in Nigeria.
Application of Mixed Reality in Medical Training and Surgical Planning Focused on Minimally Invasive Surgery
Authors: Sánchez-Margallo Juan A. , Plaza de Miguel Carlos , Fernández Anzules Roberto A. , Sánchez-Margallo Francisco M.
Published: October 2021

Introduction:Medical training is a long and demanding process, in which the first stages are usually based on two-dimensional, static, and unrealistic content. Conversely, advances in preoperative imaging have made it an essential part of any successful surgical procedure. However, access to this information often requires the support of an assistant and may compromise sterility in the surgical process. Herein, we present two solutions based on mixed reality that aim to improve both training and planning in minimally invasive surgery.

Materials and Methods:Applications were developed for the use of the Microsoft HoloLens device. The urology training application provided access to a variety of anatomical and surgical training contents. Expert urological surgeons completed a questionnaire to evaluate its use. The surgical planning solution was used during laparoscopic renal tumorectomy in an experimental model and video-assisted right upper lobectomy in an adult patient. Surgeons reported their experience using this preoperative planning tool for surgery.

Results:The solution developed for medical training was considered a useful tool for training in urological anatomy, facilitating the translation of this knowledge to clinical practice. Regarding the solution developed for surgical planning, it allowed surgeons to access the patient’s clinical information in real-time, such as preoperative imaging studies, three-dimensional surgical planning models, or medical history, facilitating the surgical approach. The surgeon’s view through the mixed reality device was shared with the rest of the surgical team.

Conclusions:The mixed reality-based solution for medical training facilitates the transfer of knowledge into clinical practice. The preoperative planning tool for surgery provides real-time access to essential patient information without losing the sterility of the surgical field. However, further studies are needed to comprehensively validate its clinical application.
Transformative Frames for Climate Threat in the Anthropocene
Authors: Hurlbert Margot
Published: October 2021

This is a mini review of literature surrounding new inter and transdisciplinary frames of the threat of climate change including “Anthropocene,” linked with “climate crisis,” “climate emergency,” and “climate catastrophe”. The specific meanings and consequences of these frames are discussed and an argument why these frames are needed and risk is not enough. Ultimately, this article concludes these new framings assist transformative change by opening up climate change science, citizen engagement, and policy response. However, no one frame and no one associated policy is supported, but a plurality, dependent on context, and culture.
Is Sport Sustainable?—It Depends!
Authors: Tangen Jan Ove
Published: October 2021

Is sport sustainable? Could sport be sustainable? Is there hope? The short answer is: it depends. This article discusses the six most essential issues on which answers to the questions above depend. First, it depends on what we already know about sport and sustainability. Second, it depends on how we observe or define sport and sustainability, respectively. Third, it depends on the ontology and epistemology on which the definitions and theories are based. Fourth, it depends on how we describe and explain the relationships and dependencies between sport, society and the environment. Fifth, it depends on how historical and sociological theories describe and explain how societies and civilizations operate, develop and eventually collapse. Sixth, it depends on whether we believe is it possible to plan and steer the future. These conditions indicate that the questions are challenging to answer but not impossible. Based on sociological systems theory, the author concludes that sport will not be sustainable unless modernity changes into a different kind of society—a world society that operates and governs from the binary code of sustainable/unsustainable instead of today's statal code of power/powerless.
The Impact of Palliative Transurethral Resection of the Prostate on the Prognosis of Patients With Bladder Outlet Obstruction and Metastatic Prostate Cancer: A Population-Matched Study
Authors: Fang Kun , Song Pan , Zhang Jiahe , Yang Luchen , Liu Peiwen , Lu Ni , Dong Qiang
Published: October 2021

Objective: This study aimed to evaluate the survival outcomes of patients with bladder outlet obstruction (BOO) and metastatic prostate cancer (mPCa) after having a palliative transurethral resection of the prostate (pTURP) surgery.

Methods: We identified patients with mPCa between 2004 and 2016 in the Surveillance, Epidemiology, and End Results (SEER) database. Patients who received pTURP and non-surgical therapy were identified. A propensity-score matching was introduced to balance the covariate. Kaplan–Meier analysis and COX regression were conducted to evaluate the overall survival (OS) and cancer-specific survival (CSS) outcomes.

Results: A total of 36,003 patients were identified; 2,823 of them were in the pTURP group and 33,180 were in the non-surgical group. The survival curves of the overall cohort showed that the pTURP group was associated with worse outcomes in both OS (HR: 1.12, 95% CI: 1.07–1.18, p < 0.001) and CSS (HR: 1.08, 95% CI: 1.02–1.15, p = 0.004) compared with the non-surgical group. The mean survival time in the overall cohort of the pTURP group was shorter than the non-surgical group in both OS [35.13 ± 1.53 vs. 40.44 ± 0.59 months] and CSS [48.8 ± 1.27 vs. 55.92 ± 0.43 months]. In the matched cohort, the pTURP group had significantly lower survival curves for both OS (HR: 1.25, 95% CI: 1.16–1.35, p < 0.001) and CSS (HR: 1.23, 95% CI: 1.12–1.35, p < 0.001) than the non-surgical group. pTURP significantly reduced the survival months of the patients (36.49 ± 0.94 vs. 45.52 ± 1.23 months in OS and 50.1 ± 1.49 vs. 61.28 ± 1.74 months in CSS). In the multivariate COX analysis, pTURP increased the risk of overall mortality (HR: 1.19, 95% CI: 1.09–1.31, p < 0.001) and cancer-specific mortality CSS (HR: 1.23, 95% CI: 1.14–1.33, p < 0.001) compared with the non-surgical group.

Conclusions: For mPCa patients with BOO, pTURP could reduce OS and CSS while relieving the obstruction.
Bridging Sex-Specific Differences in the CAR-Mediated Hepatocarcinogenesis of Nitrapyrin Using Molecular and Apical Endpoints
Authors: Murphy Lynea , LeBaron Matthew J. , Johnson Kamin , Rasoulpour Reza J. , Wang Xiujuan , LaRocca Jessica
Published: October 2021

Nitrapyrin, a nitrification inhibitor, produces liver tumors in B6C3F1 mice. In a 2-year oncogenicity study, increased incidence of mice with hepatocellular tumors was observed following exposure to 125 (females only) or 250 mg/kg/day (males and females) nitrapyrin in the diet. Previous data was generated in male mice to support a mode-of-action (MoA) characterized by constitutive androstane receptor (CAR) nuclear receptor (NR) activation, increased hepatocellular proliferation, and subsequent hepatocellular foci and tumor formation. Uncertainty as to the relevance of this MoA for females remained given the increased sensitivity to tumor formation in female mice. A targeted MoA study was conducted to evaluate CAR activation and hepatic responses in female mice treated with the female carcinogenic dose of nitrapyrin for 4 days. Nitrapyrin induced a treatment-related increase in hepatocellular hypertrophy and hepatocellular proliferation. Nitrapyrin also induced a dose-related increase in the Cyp2b10/CAR-associated transcript and liver weights. Nitrapyrin-induced liver weights and Cyp2b10 gene expression for both males and females were compared to data generated from three other established CAR activators; methyl isobutyl ketone, phenobarbital, and sulfoxaflor. The response observed in female mice following exposure to nitrapyrin was within range of the degree of change observed in mice following exposure to tumorigenic doses of other CAR activators. Consistent with the liver MoA in male mice, these data support a CAR-mediated mode of action for nitrapyrin-induced liver tumors in female mice, with the understanding that a focused approach minimizing animal use can bridge male and female datasets when sex-specific carcinogenic differences are observed.
Positive Influence of a Probiotic Mixture on the Intestinal Morphology and Microbiota of Farmed Guinea Fowls (Numida meleagris)
Authors: Galosi Livio , Desantis Salvatore , Roncarati Alessandra , Robino Patrizia , Bellato Alessandro , Nebbia Patrizia , Ferrocino Ilario , Santamaria Nicoletta , Biagini Lucia , Filoni Lorenzo , Attili Anna Rita , Rossi Giacomo
Published: October 2021

To understand the effectiveness of a probiotic mixture on intestinal morphology, mucus layer composition, and cecal microbiota diversity, 40 10-day-old Guinea fowls (Numida meleagris) were assigned to two groups: the control group (C), receiving drinking water, and the treated group (P), receiving water plus a commercial multi-strain probiotic (Slab51®, 2 × 1011 CFU/L). Birds were slaughtered after 4 months, and the intestines were collected. Samples from the duodenum, ileum, and cecum were processed for morphological and morphometric studies, and conventional glycohistochemistry. Cecal samples were also used to assess the microbiota by 16S metataxonomic approach. Group P showed significant increase in the villus height (p < 0.001 in the duodenum and p < 0.05 in the ileum and cecum), villus width (p < 0.05 in all investigated tracts), depth of crypts (p < 0.001 in the duodenum and cecum; p < 0.05 in the ileum), and goblet cells per villus (p < 0.001 in all investigated tracts) compared with group C. Cecal microbiota of the birds varied considerably and comparing the relative abundance of the main observational taxonomic units (OTUs), a positive enrichment of several beneficial taxa, such as Oscillospira, Eubacterium, Prevotella, and members of the Ruminococcaceae, was observed. The enrichment of those taxa can improve microbiota stability and resilience facing environmental stresses, enhancing its resistance against invading pathogens. Ruminococcaceae, which represent the most important taxon in both groups, and Prevotella have a key role in the gut physiology due to the production of short-chain fatty acids (SCFAs), which are a vital energy source for enterocytes, improve glucose metabolism, and exert an overall anti-inflammatory effect. Probiotic administration enriches the presence of Coprococcus, Oscillospira, and Eubacterium taxa that produce butyrate, which exerts a beneficial effect on growth performance, structure of villi, and pathogen control and has anti-inflammatory properties too. This study indicates that Slab51® supplementation positively affects the morphology and microbiota diversity of the guinea fowl intestine.
Synergistic Regulatory Effect of Inhibin and Anti-Müllerian Hormone on Fertility of Mice
Authors: Yu Xue , Qiao Tong , Hua Liping , Liu Shuanghang , Zhao Xinzhe , Lv Ce , Zhao Xuhong , Wang Jing , Han Li , Yang Liguo , Liang Aixin
Published: October 2021

Inhibin (INH) and anti-Müllerian hormone (AMH) are essential in ovarian folliculogenesis and play an inhibitory role in mammalian fertility. However, the interactive effect of INH and AMH on the animal reproduction remains unknown. This study aimed to determine the possible interaction and synergy between INH and AMH in steroidogenesis by primary granulosa cells, and investigate their synergistic effect on fertility in mice. In in vitro granulosa cell culture system, we found that the treatment of either INHA or AMH had no significant effect on basal estradiol and progesterone production, whereas both significantly attenuated FSH-induced steroid hormone secretion. Importantly, combined treatment with INHA and AMH showed additive inhibitory effect on FSH-induced estradiol and progesterone production, accompanying a significant downregulation in the expression of FSH-stimulated CYP19A1, HSD3B, CYP11A1, StAR transcripts. The interrelationship of INH and AMH combinations was further investigated through active immune neutralization strategy. Female mice were immunized against INH and AMH eukaryotic expression plasmids, and the litter size was recorded after successfully mating. We observed that both INH and AMH plasmids were able to induce either anti-AMH or anti-INH antibodies in the immunized mice. In comparison with the control group, co-immunization with INH and AMH plasmids induced higher levels of estradiol, resulting in more litter size. Moreover, there was no significant difference on the offspring's weight between each group. Collectively, the results of the present study suggest that INH and AMH have synergistic effect in regulating steroidogenesis and the litter size in mice.
Identification of the O/ME-SA/Ind-2001e Sublineage of Foot-and-Mouth Disease Virus in Cambodia
Authors: Ryoo Soyoon , Lee HyunJi , Lim Da-Rae , Lee Jung-Won , Bunnary Seng , Tum Sothyra , Lee Dong Sook , Hwang Hyeonwoo , Jeong SomGyeol , Nah JinJu , Ku Bok Kyung , Kim Jae-Myung , Cha Sang-Ho
Published: October 2021

Foot-and-mouth (FMD) is endemic in Cambodia with numerous outbreaks in cattle, pigs and other susceptible animal species reported every year. Historically, these outbreaks were caused by the FMD virus (FMDV) of serotype O PanAsia and Mya-98 lineages and serotype A Sea-97 lineage. However, the trans-pool movement of FMDV between inter-pool regions or countries throughout FMD endemic regions has raised concerns regarding infection with the new genotype or serotype of FMDV in Cambodia. In this study, 19 sequences of VP1 coding region obtained from 33 clinical samples collected from FMDV-affected cattle farms in Cambodia during January to March 2019 were genetically characterized to identify the genotypes/lineages of FMDV.

Phylogenetic analysis of VP1 coding sequences revealed that recent field viruses belonged to O/ME-SA/Ind-2001e (15.8%), O/ME-SA/PanAsia (52.7%), and A/ASIA/Sea-97 (31.5%). Besides, the field viruses of O/ME-SA/Ind-2001e in Cambodia showed 93.5–96.8% identity with the VP1 coding sequences of the same sublineage viruses from pool 1 and 2 surrounding Cambodia. This is the first report of O/ME-SA/Ind-2001e infection in Cambodia, suggesting that the trans-pool movement of the new genotype should be closely monitored for efficient control of FMD.
Combinations of Linear Type Traits Affecting the Longevity in Hungarian Holstein-Friesian Cows
Authors: Török Evelin , Komlósi István , Szőnyi Viktor , Béri Béla , Mészáros Gábor , Posta János
Published: October 2021

Several research studies confirm the association of the linear type traits with longevity, but only with one trait at a time. The aim of our study was to analyse the influence of combinations for linear type traits on longevity in the Hungarian Holstein-Friesian cows. Data were provided by four herds; the filtered dataset consisted of 17,717 cows. From the 14 available linear type traits, the most important combinations were identified based on principal components and cluster analysis. From the six identified combinations, only three (chest width-body depth, fore udder attachment-udder depth, angularity-rear udder height) proved to have a significant effect on longevity. A wide chest and deep body caused a high-risk ratio of culling. The lowest risk ratio was observed with cows having intermediate chest width and intermediate body depth. Very angular cows having low rear udder height were at the highest risk of culling. The lowest culling risk was found in cows with a lack of angularity and high rear udder height. Weak and loose fore udder along with deep udder had increased culling risk. Strong and tight fore udder subclasses were the most favourable as their risk ratios decreased towards the shallowing of udder depth.
Effects of Milk Urea Nitrogen (MUN) and Climatological Factors on Reproduction Efficiency of Holstein Friesian and Jersey Cows in the Subtropics
Authors: Webb Edward Cottington , de Bruyn Elandri
Published: October 2021

This study investigated the effects of MUN and climatological factors on the inter calving period (ICP), reproductive performance (RP%), and reproductive index (RI) in Holstein Friesian (n = 1177) and Jersey cows (n = 3305) in different seasons in the subtropics. Threshold values for MUN on the reproduction of dairy cows in the subtropics remain controversial due to complex environmental interactions, especially with high environmental temperatures. A retrospective analysis was conducted of data obtained from the National Milk Recording scheme of the Agricultural Research Council (ARC) in South Africa. The results confirm that MUN influences the reproduction of dairy cows in the subtropics. MUN concentrations exceeding 18.1 ± 4.28 mg/dL in Holstein Friesian cows and 13.0 ± 4.70 mg/dL in Jersey cows extended the inter calving period (ICP), and decreased RP% and RI. Jersey cows have a lower threshold MUN concentration compared to Holstein Friesian cows, but they are not adversely affected by high humidity or temperatures, while Holstein Friesian cows are.
Social and Seasonal Factors Contribute to Shifts in Male African Elephant (Loxodonta africana) Foraging and Activity Patterns in Kruger National Park, South Africa
Authors: du Plessis Kara , Ganswindt Stefanie Birgit , Bertschinger Henk , Crossey Bruce , Henley Michelle Deborah , Ramahlo Mmatsawela , Ganswindt André
Published: October 2021

African savannah elephants (Loxodonta africana) are well-known as ecosystem engineers with the ability to modify vegetation structure. The present study aimed to examine how male elephant foraging behaviour is affected across (a) season (wet versus dry); (b) time of day (before or after noon); (c) presence or absence of other elephants; and (d) reproductive state (musth versus no musth). Six radio-collared adult elephant bulls were observed twice per week from June 2007–June 2008 in Kruger National Park (KNP), South Africa. Using generalized linear mixed effect modeling, results indicate that elephant bulls graze more during the wet season and browse more during the dry season. To potentially offset the costs associated with thermoregulation during the heat of the day, KNP elephants spent more time foraging during the morning, and more time resting during the afternoon. Male elephants also foraged significantly less when they were associated with females compared to when they were alone or with other males. This is likely due to male–female associations formed mainly for reproductive purposes, thus impeding on male foraging behaviours. In contrast, the condition of musth, defined by the presence of related physical signs, had no significant effect on foraging behaviour.
Does Social Complexity Drive Vocal Complexity? Insights from the Two African Elephant Species
Authors: Hedwig Daniela , Poole Joyce , Granli Petter
Published: October 2021

The social complexity hypothesis (SCH) for communication states that the range and frequency of social interactions drive the evolution of complex communication systems. Surprisingly, few studies have empirically tested the SHC for vocal communication systems. Filling this gap is important because a co-evolutionary runaway process between social and vocal complexity may have shaped the most intricate communication system, human language. We here propose the African elephant Loxodonta spec. as an excellent study system to investigate the relationships between social and vocal complexity. We review how the distinct differences in social complexity between the two species of African elephants, the forest elephant L. cyclotis and the savanna elephant L. africana, relate to repertoire size and structure, as well as complex communication skills in the two species, such as call combination or intentional formant modulation including the trunk. Our findings suggest that Loxodonta may contradict the SCH, as well as other factors put forth to explain patterns of vocal complexity across species. We propose that life history traits, a factor that has gained little attention as a driver of vocal complexity, and the extensive parental care associated with a uniquely low and slow reproductive rate, may have led to the emergence of pronounced vocal complexity in the forest elephant despite their less complex social system compared to the savanna elephant. Conclusions must be drawn cautiously, however. A better understanding of vocal complexity in the genus Loxodonta will depend on continuing advancements in remote data collection technologies to overcome the challenges of observing forest elephants in their dense rainforest habitat, as well as the availability of directly comparable data and methods, quantifying both structural and contextual variability in the production of rumbles and other vocalizations in both species of African elephants.
Fibropapillomatosis and Chelonid Alphaherpesvirus 5 Infection in Kemp’s Ridley Sea Turtles (Lepidochelys kempii)
Authors: Page-Karjian Annie , Whitmore Liam , Stacy Brian A. , Perrault Justin R. , Farrell Jessica A. , Shaver Donna J. , Walker J. Shelby , Frandsen Hilary R. , Rantonen Elina , Harms Craig A. , Norton Terry M. , Innis Charles , Yetsko Kelsey , Duffy David J.
Published: October 2021

Fibropapillomatosis (FP), a debilitating, infectious neoplastic disease, is rarely reported in endangered Kemp’s ridley sea turtles (Lepidochelys kempii). With this study, we describe FP and the associated chelonid alphaherpesvirus 5 (ChHV5) in Kemp’s ridley turtles encountered in the United States during 2006–2020. Analysis of 22 case reports of Kemp’s ridley turtles with FP revealed that while the disease was mild in most cases, 54.5% were adult turtles, a reproductively valuable age class whose survival is a priority for population recovery. Of 51 blood samples from tumor-free turtles and 12 tumor samples from turtles with FP, 7.8% and 91.7%, respectively, tested positive for ChHV5 DNA via quantitative polymerase chain reaction (qPCR). Viral genome shotgun sequencing and phylogenetic analysis of six tumor samples show that ChHV5 sequences in Kemp’s ridley turtles encountered in the Gulf of Mexico and northwestern Atlantic cluster with ChHV5 sequences identified in green (Chelonia mydas) and loggerhead (Caretta caretta) sea turtles from Hawaii, the southwestern Atlantic Ocean, and the Caribbean. Results suggest an interspecific, spatiotemporal spread of FP among Kemp’s ridley turtles in regions where the disease is enzootic. Although FP is currently uncommon in this species, it remains a health concern due to its uncertain pathogenesis and potential relationship with habitat degradation.
Effect of Raw and Extruded Propionic Acid-Treated Field Beans on Energy and Crude Protein Digestibility (In-Vitro and In-Vivo), Growth and Carcass Quality in Grow-Finisher Pigs
Authors: Torres-Pitarch Alberto , Perez-Vendrell Anna M. , Manzanilla Edgar G. , Gardiner Gillian E. , Ryan Tomas , O Doherty John V. , Torrallardona David , Lawlor Peadar G.
Published: October 2021

The in-vitro ileal digestibility of dry matter (DM), organic matter (OM), and crude protein (CP) of field beans treated with propionic acid (trFB) and extruded trFB (exFB) was determined in experiment 1. The DE and dCP values of trFB and exFB were determined using the difference method in experiment 2. The effect of replacing SBM with trFB and exFB in grow-finisher diets on growth, carcass quality, apparent ileal digestibility (AiD), and total tract digestibility (ATTD) of DM, OM, gross energy (GE), and CP were investigated in experiment 3. In exp. 1, in-vitro digestibility of exFB compared to trFB was unchanged for DM (p = 0.12), increased for OM (p < 0.05), and increased for CP (p < 0.05). In exp. 2, the DE value of trFB and exFB was 14.38 and 15.75 MJ/kg respectively; and the dCP value was 21.35% and 21.42% respectively (on DM basis). In exp. 3, ADFI was higher for pigs fed trFB and exFB compared to the control diet (CON; p < 0.05), while ADG, FCR and carcass quality parameters of pigs did not differ among treatments (p > 0.05).
A Culture Change: Impact of a Pediatric Antimicrobial Stewardship Program Based on Guideline Implementation and Prospective Audit with Feedback
Authors: Bagga Bindiya , Stultz Jeremy S. , Arnold Sandra , Lee Kelley R.
Published: October 2021

Reports analyzing the impact of pediatric antimicrobial stewardship programs (ASP) over long periods of time are lacking. We thus report our ASP experience in a pediatric tertiary referral center over a long-term period from 2011 to 2018. Our ASP was implemented in 2011. The program was based primarily on guideline development with key stakeholders, engaging and educating providers, followed by prospective audit with feedback (PAF). Monitored antibiotics included meropenem, piperacillin–tazobactam, and cefepime, followed by the addition of ceftriaxone, ceftazidime, cefotaxime, ciprofloxacin, levofloxacin, linezolid, and vancomycin at various time points. Specifically, the program did not implemented the core strategy of formulary restriction with prior authorization. Process- and outcome-related ASP measures were analyzed. We saw a 32% decrease in overall antibiotic utilization, a 51% decrease in the utilization of antibiotics undergoing PAF, and a 72% reduction in the use of broad-spectrum antibiotics such as meropenem. There was a concomitant increase in organism susceptibility and a reduction in yearly drug purchasing costs of over USD 560,000 from baseline without changes in sepsis-related mortality. Our study highlights that a pediatric ASP based primarily on the principles of guideline development and PAF can improve antibiotic utilization and institutional bacterial susceptibilities without a detrimental impact on patient outcomes by changing the culture of antimicrobial utilization within the institution.
Associations between Dust Exposure and Hospitalizations in El Paso, Texas, USA
Authors: Herrera-Molina Estrella , Gill Thomas E. , Ibarra-Mejia Gabriel , Jeon Soyoung
Published: October 2021

The Southwestern USA has been identified as one of the most persistent dust-producing regions of North America, where exposure to inhalable particulate matter (PM10) originating from desertic landscape during dust events/dust exposures (DEs) can reach hazardous levels. El Paso, Texas’s ambient air has reached hazardous levels of PM10 from dust with near zero visibility due to these natural events originating in the surrounding Chihuahuan Desert. The aim of this study was to investigate whether dust exposures in El Paso (generally acute, short-term exposures from nearby source areas) are associated with significant increases in hospitalizations on the day of the exposure and up to seven days afterwards. Using a Poisson regression, it was found that the relative risks of hospitalizations due to a variety of conditions were associated with dust exposures (through increases of 100 μg/m3 maximum hourly PM10 and/or increases of 4.5 m/s maximum hourly wind speed) in El Paso County, Texas between 2010 and 2014. Valley fever, coronary atherosclerosis, genitourinary diseases, neurodegenerative diseases, injury and poisoning, circulatory system conditions, respiratory system diseases, births, septicemia, Associated Diseases (the aggregation of hospital admissions for all causes, each associated with at least 5% of hospitalizations), and all ICD-9 admissions were significantly positively associated with dust exposures, indicated from higher to lower significant risk, at different lag periods after exposure. These findings, showing that an association does exist between dust exposures and hospitalizations, have important implications for residents of the world’s dryland cities.
Turbulence: Vertical Shear of the Horizontal Wind, Jet Streams, Symmetry Breaking, Scale Invariance and Gibbs Free Energy
Authors: Tuck Adrian F.
Published: October 2021

The increase of the vertical scaling exponent of the horizontal wind Hv(s) with altitude from the surface of the Pacific Ocean to 13 km altitude, as observed by GPS dropsondes, is investigated. An explanation is offered in terms of the decrease of gravitational force and decrease of quenching efficiency of excited photofragments from ozone photodissociation with increasing altitude (decreasing pressure). Turbulent scaling is examined in both the vertical from dropsondes and horizontal from aircraft observations; the scaling exponents H for both wind speed and temperature in both coordinates are positively correlated with traditional measures of jet stream strength. Interpretation of the results indicates that persistence of molecular velocity after collision induces symmetry breaking emergence of hydrodynamic flow via the mechanism first modelled by Alder and Wainwright, enabled by the Gibbs free energy carried by the highest speed molecules. It is suggested that the combined effects have the potential to address the cold bias in numerical models of the global atmosphere.
Control of Airborne Microorganisms by Essential Oils Released by VaxiPod
Authors: Mirskaya Ekaterina , Agranovski Igor E.
Published: October 2021

Currently, due to the global pandemic caused by severe acute respiratory syndrome coronavirus SARS-CoV-2, new procedures and devices for effective disinfection of indoor air are of obvious interest. Various studies demonstrated quite broad ranges of the efficiency of essential oils in the control of biological aerosols. This project reports the results of investigation of the antimicrobial activity of essential oils natural for Australia (tea tree oil, eucalyptus oil and lemon myrtle) distributed by newly developed VaxiPod device for various scenarios, including bacterial, viral and fungal inactivation on various surfaces and in aerosol form. It was found that the device was capable of operating continuously over 24-h periods, providing sufficient aerosol concentration to efficiently inactivate microorganisms both on the surface and in airborne form. Twenty-four to forty-eight hours were required to achieve inactivation above 90% of most of the tested microbes on solid surfaces (stainless steel discs and agar plates), whilst similar efficiency of inactivation on fibrous filter surface as well as in aerosol form was achieved over 30–60 min of the process run. The results look very promising for further development of bioaerosol inactivating procedures and technologies for air quality control applications.
Sound Propagation Modelling for Manned and Unmanned Aircraft Noise Assessment and Mitigation: A Review
Authors: Kapoor Rohan , Kloet Nicola , Gardi Alessandro , Mohamed Abdulghani , Sabatini Roberto
Published: October 2021

This paper addresses one of the recognized barriers to the unrestricted adoption of Unmanned Aircraft (UA) in mainstream urban use—noise—and reviews existing approaches for estimating and mitigating this problem. The aircraft noise problem is discussed upfront in general terms by introducing the sound emission, propagation, and psychoacoustic effects. The propagation of sound in the atmosphere, which is the focus of this paper, is then analysed in detail to isolate the environmental and operational factors that predominantly influence the perceived noise on the ground, especially looking at large-scale low-altitude UA operations, such as in the envisioned Urban Air Mobility (UAM) concepts. The physics of sound propagation are presented, considering all attenuation effects and the anomalies due to Doppler and atmospheric effects, such as wind, thermal inversion, and turbulence. The analysis allows to highlight the limitations of current mainstream aircraft noise modelling and certification approaches and, in particular, their inadequacy in addressing the noise of UA and, more generally, UAM vehicles. This finding is important considering that, although reducing noise at the source has remained a priority for manufacturers to enable the scaling up of UAM and drone delivery operations in the near future, the impact of poorly considered propagation and psychoacoustic effects on the actual perceived noise on the ground is equally important for the same objective. For instance, optimizing the flight paths as a function of local weather conditions can significantly contribute to minimizing the impact of noise on communities, thus paving the way for the introduction of full-scale UAM operations. A more reliable and accurate modelling of noise ground signatures for both manned and unmanned low-flying aircraft will aid in identifying the real-time data stream requirements from distributed sensors on the ground. New developments in surrogate sound propagation models, more pervasive real-time sensor data, and suitable computing resources are expected to both yield more reliable and effective estimates of noise reaching the ground listeners and support a dynamic planning of flight paths.
NERWS: Towards Improving Information Retrieval of Digital Library Management System Using Named Entity Recognition and Word Sense
Authors: Aliwy Ahmed , Abbas Ayad , Alkhayyat Ahmed
Published: October 2021

An information retrieval (IR) system is the core of many applications, including digital library management systems (DLMS). The IR-based DLMS depends on either the title with keywords or content as symbolic strings. In contrast, it ignores the meaning of the content or what it indicates. Many researchers tried to improve IR systems either using the named entity recognition (NER) technique or the words’ meaning (word sense) and implemented the improvements with a specific language. However, they did not test the IR system using NER and word sense disambiguation together to study the behavior of this system in the presence of these techniques. This paper aims to improve the information retrieval system used by the DLMS by adding the NER and word sense disambiguation (WSD) together for the English and Arabic languages. For NER, a voting technique was used among three completely different classifiers: rules-based, conditional random field (CRF), and bidirectional LSTM-CNN. For WSD, an examples-based method was used to implement it for the first time with the English language. For the IR system, a vector space model (VSM) was used to test the information retrieval system, and it was tested on samples from the library of the University of Kufa for the Arabic and English languages. The overall system results show that the precision, recall, and F-measures were increased from 70.9%, 74.2%, and 72.5% to 89.7%, 91.5%, and 90.6% for the English language and from 66.3%, 69.7%, and 68.0% to 89.3%, 87.1%, and 88.2% for the Arabic language.
Fine-Grained Algorithm for Improving KNN Computational Performance on Clinical Trials Text Classification
Authors: Jasmir Jasmir , Nurmaini Siti , Tutuko Bambang
Published: October 2021

Text classification is an important component in many applications. Text classification has attracted the attention of researchers to continue to develop innovations and build new classification models that are sourced from clinical trial texts. In building classification models, many methods are used, including supervised learning. The purpose of this study is to improve the computational performance of one of the supervised learning methods, namely KNN, in building a clinical trial document text classification model by combining KNN and the fine-grained algorithm. This research contributed to increasing the computational performance of KNN from 388,274 s to 260,641 s in clinical trial texts on a clinical trial text dataset with a total of 1,000,000 data.
The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery
Authors: Brézulier Damien , Chaigneau Louis , Jeanne Sylvie , Lebullenger Ronan
Published: October 2021

Cleft lip and palate is the fourth most common congenital malformation. Its prevalence is about 1 in 750 to 1 in 2000 live births. The consequences of this malformation are major: maxillary growth deficit, unaesthetic appearance, phonation disorders, difficulty in eating, and psycho-social disorders. Cleft palate repair establishes the division between the oral and nasal cavities. The alveolar bone graft is a key step. Different sites of autogenous bone harvesting are used, the most common being the iliac crest. Nevertheless, the large number of complications associated with harvesting has led to the use of substitute biomaterials. Bioactive glasses, discovered in 1969, are a group of synthetic silica-based materials with bone-bonding properties. Although 45S5 granular composition is commonly used in bone surgery to repair critical defects, it is only rarely used in the repair of cleft palates because this galenic form is only moderately adapted. However, advances in bone tissue engineering allow the shaping of three-dimensional scaffolds, which support colonization by host cells. Recent advances in computer-aided design/computer-aided manufacturing (CAD/CAM) have even led to the 3D printing of scaffolds combining 45S5 bioglass with a natural and biocompatible poly-lactic acid matrix. The shape of the parts is customized and adapted to the particular shape of the critical bone defects. The objective of this literature review is to highlight the particularities of alveolar defects subsequent to facial clefts, then to detail the characteristics of the materials and technologies used to elaborate 3D matrices by bioprinting. Finally, we will explore research directions regarding their use in reconstructive surgery of cleft palates.
A Treasure of Bioactive Compounds from the Deep Sea
Authors: Saide Assunta , Lauritano Chiara , Ianora Adrianna
Published: October 2021

The deep-sea environment is a unique, challenging extreme habitat where species have had to adapt to the absence of light, low levels of oxygen, high pressure and little food. In order to survive such harsh conditions, these organisms have evolved different biochemical and physiological features that often have no other equivalent in terrestrial habitats. Recent analyses have highlighted how the deep sea is one of the most diverse and species-rich habitats on the planet but less explored compared to more accessible sites. Because of their adaptation to this extreme environment, deep-sea species have the potential to produce novel secondary metabolites with potent biological activities. Recent advances in sampling and novel techniques in microorganism culturing and chemical isolation have promoted the discovery of bioactive agents from deep-sea organisms. However, reports of natural products derived from deep-sea species are still scarce, probably because of the difficulty in accessing deep-sea samples, sampling costs and the difficulty in culturing deep-sea organisms. In this review, we give an overview of the potential treasure represented by metabolites produced by deep marine species and their bioactivities for the treatment and prevention of various human pathologies.
Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO2/BiOI/Ag2S Composites for Detection of Procalcitonin
Authors: Zhang Nuo , Feng Jinhui , Zhao Guanhui , Duan Xiaoyi , Wang Yaoguang , Zhang Daopeng , Wei Qin
Published: October 2021

Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO2 porous nanoflowers with good photocatalytic performance were prepared by combining hydrothermal synthesis and calcining. BiOI nanoflowers were synthesized by facile ultrasonic mixed reaction. Ag2S quantum dots were deposited on SnO2/BiOI composites by in situ growth method. The SnO2/BiOI/Ag2S composites with excellent photoelectric properties were employed as substrate material, which could provide significantly enhanced and stable signal because of the energy level matching of SnO2, BiOI and Ag2S and the good light absorption performance. Accordingly, a PEC immunosensor based on SnO2/BiOI/Ag2S was constructed by using the layered modification method to achieve high sensitivity analysis of PCT. The linear dynamic range of the detection method was 0.50 pg·mL−1~100 ng·mL−1, and the detection limit was 0.14 pg·mL−1. In addition, the designed PEC immunosensor exhibited satisfactory sensitivity, selectivity, stability and repeatability, which opened up a new avenue for the analyzation of PCT and further provided guidance for antibiotic therapy.