bluuebunny/crossref_metadata_2025 huggingface dataset:
Carrying Police Load Increases Gait Asymmetry in Ground Reaction Forces and Plantar Pressures Beneath Different Foot Regions in a Large Sample of Police Recruits
Authors: Kasović Mario , Štefan Andro , Štefan Lovro
Published: September 2024

Background: Although carrying external load has negative effects on gait biomechanics, little evidence has been provided regarding its impact on body asymmetry. The main purpose of the present study was to examine, whether standardized equipment produced greater gait asymmetries in ground reaction force and plantar pressure. Methods: For the purpose of this study, we recruited 845 police recruits (609 men and 236 women; 72.1% men and 27.9% women) measured in two conditions: (i) ‘no load’ and (ii) ‘a 3.5 kg load’. Absolute values in ground reaction forces and plantar pressures beneath the different foot regions were assessed with pedobarographic platform (Zebris FDM). Asymmetry was calculated as (xright − xleft)/0.5 × (xright + xleft) × 100%, where ‘x’ represented a given parameter being calculated and a value closer to 0 denoted greater symmetry. Results: Significant differences in ground reaction forces and plantar pressures between the left and right foot were observed, when adding ‘a 3.5 kg load’. Compared to the ‘no load’ condition, carrying ‘a 3.5 kg load’ significantly increased gait asymmetries for maximal ground reaction forces beneath the forefoot (ES = 0.29), midfoot (ES = 0.20) and hindfoot (ES = 0.19) regions of the foot. For maximal plantar pressures, only the asymmetry beneath the midfoot region of the foot significantly increased (ES = 0.19). Conclusions: Findings of this study indicate that ‘a 3.5 kg load’ significantly increases ground reaction force and plantar pressure gait asymmetries beneath the forefoot and midfoot regions, compared to ‘no load’ condition. Due to higher loads, increases in kinetic gait asymmetries may have negative effects on future pain and discomfort in the foot area, possibly causing stress fractures and deviated gait biomechanics in police recruits.
Beyond Inverse Dynamics: Methods for Assessment of Individual Muscle Function during Gait
Authors: Piazza Stephen J.
Published: September 2024

Three-dimensional motion analysis performed in the modern gait analysis laboratory provides a wealth of information about the kinematics and kinetics of human locomotion, but standard gait analysis is largely restricted to joint-level measures. Three-dimensional joint rotations, joint moments, and joint powers tell us a great deal about gait mechanics, but it is often of interest to know about the roles that muscles play. This narrative review surveys work that has been done, largely over the past four decades, to augment standard gait analysis with muscle-level assessments of function. Often, these assessments have incorporated additional technology such as ultrasound imaging, or complex modeling and simulation techniques. The review discusses measurements of muscle moment arm during walking along with assessment of muscle mechanical advantage, muscle–tendon lengths, and the use of induced acceleration analysis to determine muscle roles. In each section of the review, examples are provided of how the auxiliary analyses have been used to gain potentially useful information about normal and pathological human walking. While this work highlights the potential benefits of adding various measures to gait analysis, it is acknowledged that challenges to implementation remain, such as the need for specialized knowledge and the potential for bias introduced by model choices.
Comparing the Immune Response to PEEK as an Implant Material with and without P-15 Peptide as Bone Graft Material in a Rabbit Long Bone Model
Authors: Cheng Boyle C. , Swink Isaac R. , Cheng Cooper T. , Corcoran Owen G. , Wang Vicki Z. , McClain Edward J. , Vyas Praveer S. , Owen Izzy , Xu Chen , Altman Daniel T. , Yu Alexander K.
Published: September 2024

P-15 is a 15-amino-acid-long biomimetic peptide widely demonstrated to enhance osteogenesis in vivo. Despite the prevalence of polyether-ether-ketone (PEEK) in interbody device manufacturing, a growing body of evidence suggests it may produce an unfavorable immune response. The purpose of this preliminary study was to characterize the immune response and new bone growth surrounding PEEK implants with and without a P-15 peptide-based osteobiologic. A bilateral femoral defect model was conducted using New Zealand white rabbits. A total of 17 test subjects received one implant in each distal femur, either with or without bone graft material. Animals were allowed to survive to 4 or 8 weeks, at which time the femurs were collected and subjected to micro-computer tomography (microCT) or cytokine analysis. MicroCT analysis included the quantification of bone growth and density surrounding each implant. The cytokine analysis of periprosthetic tissue homogenates included the quantification of interleukins (ILs) and TNF-α expression via ELISA kits. Improvements in bone volume were observed in the P-15 cohort for the regions of interest, 500–136 and 136–0 µm from the implant surface, at 8 weeks post-op. Concentrations of IL-1β, IL-4, and IL-6 cytokines were significantly higher in the P-15 cohort compared to the PEEK cohort at the 4-week timepoint. Significant reductions in the concentrations of IL-4 and IL-6 cytokines from the 4- to 8-week cohort were observed in the P-15 cohort only. The P-15 peptide has the potential to modulate the immune response to implanted materials. We observed improvements in bone growth and a more active micro-environment in the P-15 cohort relative to the PEEK control. This may indicate an earlier transition from the inflammatory to remodeling phase of healing.
Functional MRI Assessment of Brain Activity Patterns Associated with Reading in Medulloblastoma Survivors
Authors: Dalboni da Rocha Josue L. , Zou Stinnett Ping , Scoggins Matthew A. , McAfee Samuel S. , Conklin Heather M. , Gajjar Amar , Sitaram Ranganatha
Published: September 2024

Medulloblastoma, a malignant brain tumor primarily affecting children, poses significant challenges to patients and clinicians due to its complex treatment and potential long-term cognitive consequences. While recent advancements in treatment have significantly improved survival rates, survivors often face cognitive impairments, particularly in reading, impacting their quality of life. According to the double deficit theory, reading impairments are caused by deficits in one or both of two independent reading-related functions: phonological awareness and rapid visual naming. This longitudinal study investigates neurofunctional changes related to reading in medulloblastoma survivors in comparison to controls using functional MRI acquired during rapid automatized naming tasks over three annual visits. Support vector machine classification of functional MRI data reveals a progressive divergence in brain activity patterns between medulloblastoma survivors and healthy controls over time, suggesting delayed effects of cancer treatment on brain function. Alterations in brain regions involved in visual processing and orthographic recognition during rapid naming tasks imply disruptions in the ventral visual pathway associated with normal orthographic processing. These alterations are correlated with performance in tasks involving sound awareness, reading fluency, and word attack. These findings underscore the dynamic nature of post-treatment neurofunctional alterations and the importance of early identification and intervention to address cognitive deficits in survivors.
Neuropsychological Characteristics and Quantitative Electroencephalography in Skogholt’s Disease—A Rare Neurodegenerative Disease in a Norwegian Family
Authors: Hestad Knut A. , Aaseth Jan O. , Kropotov Juri D.
Published: September 2024

Members of three generations of a Norwegian family (N = 9) with a rare demyelinating disease were studied. Neuropsychological testing was performed using the Mini Mental Status Examination (MMSE), Wechsler Intelligence Scale-III (WAIS-III), and Hopkins Verbal Learning Test-Revised (HVLT-R). EEGs were recorded with grand averaging spectrograms and event-related potentials (ERPs) in rest and cued GO/NOGO task conditions. The results were within the normal range on the MMSE. Full-scale WAIS-III results were in the range of 69–113, with lower scores in verbal understanding than in perceptual organization, and low scores also in indications of working memory and processing speed difficulties. The HVLT-R showed impairment of both immediate and delayed recall. Quantitative EEG showed an increase in low alpha (around 7.5 Hz) activity in the temporofrontal areas, mostly on the left side. There was a deviation in the late (>300 ms) component in response to the NOGO stimuli. A strong correlation (r = 0.78, p = 0.01) between the Hopkins Verbal Learning Test (delayed recall) and the amplitude of the NOGO ERP component was observed. The EEG spectra showed deviations from the healthy controls, especially at frontotemporal deviations. Deviations in the ERP component of the NOGO trials were related to delayed recall in the Hopkins Verbal learning test.
Affective Instability: Impact of Fluctuating Emotions on Regulation and Psychological Well-Being
Authors: Dork Jennifer , Mangan Erin , Burns Lawrence , Dimenstein Eugene
Published: September 2024

Previous research has focused on understanding the occurrence of intense and fluctuating emotions and the ability to manage these emotions and affective states. These phenomena have been, respectively, labeled as affective instability and emotion regulation and have been studied among individuals diagnosed with borderline personality disorder (BPD), attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), and post-traumatic stress disorder (PTSD). Previous findings suggest that affective instability may be associated with poorer psychological well-being. The present study aims to investigate the general tendency of affective instability and capacity for emotional regulation among college students, regardless of a previous psychological diagnosis, and to understand the relationship between these processes and psychological well-being. Three questionnaires were administered to measure levels of affective instability, the ability to manage fluctuating affective states, and overall psychological well-being. The findings suggest that (1) individuals with diagnoses experience affective lability and difficulty regulating emotions at a greater rate than those without, (2) higher affective lability scores are consistent with more significant emotion dysregulation and lower overall psychological well-being, and (3) scores on the Affective lability Scale (ALS) and the Difficulties in Emotional Regulation Scale (DERS) are reliable predictors of one’s estimated Global Assessment of Functioning (GAF) scores. Although causation has not been established, the evidence suggests that individuals with diagnoses experience greater difficulty in regulating their emotions, have greater affective lability, and experience diminished psychological well-being and day-to-day functionality. Certain anecdotal evidence suggests that emotional lability can be endogenous and affect multiple aspects of an individual’s social, occupational, and personal life. By revising the existing literature and the present findings, the authors provide insights into the significance of endogenous factors in the context of affective lability and offer suggestions for future research.
Optimizing Grouting Parameters to Control Ground Deformation in the Shield Tunneling
Authors: Wang Mei , Zhao Chenyue , Yang Songsong , Xu Jingmin
Published: September 2024

In urban shield tunneling, reducing the disturbance of underground construction to the surrounding environment is important for both tunnel engineers and researchers. Among other factors, the quality of synchronous grouting is one of the crucial factors affecting the safe construction of shields. In order to determine a reasonable grouting pressure and grout amount during shield construction, the relationships among synchronous grouting pressure, grout amount and shield chamber pressure are analyzed using field monitoring data. Based on the tunnel face pressure and the ultimate yield conditions of the soil at the gap edge, a method for calculating the grouting pressure considering the overburdening load of the tunnel was proposed. Then, by linking the grout amount and the grouting pressure, an accurate calculation method for the simultaneous grout amount in shield construction was proposed. These methods were then used in the construction of the Jurong shield tunnel. The results show that the adopted grouting pressure and grout amount calculated by the proposed method, which considered the change of the overburdening load of the tunnel, can well control the ground deformation caused by the shield construction and significantly reduce the uneven settlement of the surface buildings. The proposed methods in this paper may provide a reference for other shield construction projects.
Correlation of the Near-Fault Pulse-like Ground Motion Characteristics with the Vulnerability of Buildings
Authors: Majdi Ali , Kontoni Denise-Penelope N. , Almujibah Hamad
Published: September 2024

Determining the impact of pulse-type earthquake characteristics on the vulnerability of base-isolated buildings under non-pounding conditions has yielded conflicting results in previous studies. Moreover, this issue has received less attention for pounding conditions, especially floor-to-floor pounding. Therefore, this study aims to investigate the correlation between pulse-type earthquake characteristics and the seismic response of buildings under both pounding and non-pounding conditions. In the first stage, three base-isolated buildings and one fixed-base building are analyzed separately under 40 pulse-type earthquakes using the nonlinear time history method. Three scenarios are then considered to account for pounding with adjacent buildings. In the first pounding scenario, a base-isolated building with an intermediate moment frame (IMF) is placed between two fixed-base buildings. The second scenario involves changing the base-isolated building’s superstructure system to a special moment frame (SMF). Finally, the third scenario increases the base isolation period (Tb) of the base-isolated building used in scenario two. The correlation between earthquake characteristics and the seismic response of buildings is assessed by linear regression and the Pearson correlation coefficient. The results demonstrate that peak ground acceleration (PGA) has a strong correlation with the seismic response of buildings under pounding conditions, while peak ground velocity (PGV) shows a stronger correlation under non-pounding conditions. However, predicting building vulnerability with a single pulse-type earthquake characteristic remains unreliable unless a large number of ground motions are considered. Otherwise, it is crucial to consider the correlation of all earthquake characteristics with seismic responses.
Study on the Propagation Law and Waveform Characteristics of a Blasting Shock Wave in a Highway Tunnel with the Bench Method
Authors: Yu Tao , Sun Junfeng , Wang Jianfeng , Feng Jianping , Chen Liangjun , Su Guofeng , Man Jun , Wu Zhen
Published: September 2024

In the bench method of tunnel excavation, the blasting impact from upper bench blasting poses significant risks to personnel and equipment. This study employed dynamic analysis software, ANSYS/LS-DYNA, and field testing to examine the propagation characteristics and attenuation behavior of tunnel shock waves. The findings revealed that, near the central axis of the tunnel, shock wave overpressure was lower compared to areas near the tunnel wall due to reflections from the wall. As the shock wave traveled a distance six times the tunnel diameter, it transitioned from a spherical wave to a plane wave. The attenuation coefficient for the plane wave ranged from 1.03 to 1.17. A fitting formula for shock wave overpressure attenuation, based on field test results, was proposed, and it showed good agreement with the numerical simulation results. This provided valuable theoretical insights for predicting shock wave overpressure during bench method tunnel excavation.
Decision Variables for the Use of Radioactive Iodine in Patients with Thyroid Cancer at Intermediate Risk of Recurrence
Authors: Newman Samantha K. , Patrizio Armando , Boucai Laura
Published: September 2024

The use of radioactive iodine (RAI) after total thyroidectomy for patients at the American Thyroid Association (ATA) who are at intermediate risk of recurrence is controversial. This is due to the lack of prospective randomized trials proving a benefit to recurrence or survival of RAI therapy in this group. In the absence of such evidence, clinicians struggle to recommend for or against this therapeutic approach which frequently results in overtreatment. This review describes key elements in the decision-making process that help clinicians more comprehensively evaluate the need for RAI therapy in patients with thyroid cancer at intermediate risk of recurrence. A clear definition of the purpose of RAI therapy should be conveyed to patients. In this sense, adjuvant RAI therapy intends to decrease recurrence, and ablation therapy is used to facilitate surveillance. Better stratification of the intermediate risk category into a low–intermediate subgroup and an intermediate–high-risk subgroup results in less heterogeneity and a more precise prediction of recurrence risk. The evaluation of post-operative thyroglobulin levels may prevent the overtreatment of low–intermediate-risk patients when their thyroglobulin level is <2.5 ng/mL. the integration of tumor genomics (when available) alongside pathologic features can enhance the ability of the clinician to predict iodine concentration in thyroid cancer cells. Finally, a detailed consideration of the adverse effects of RAI, patients’ comorbidities, and patient preferences will result in a patient-centered personalized approach. Systematic examination of these variables will ultimately provide a framework for making more educated decisions on the use of RAI in patients at intermediate risk of recurrence that will prevent overtreatment and minimize harm.
Deep Learning Model for Predicting Lung Adenocarcinoma Recurrence from Whole Slide Images
Authors: Su Ziyu , Afzaal Usman , Niu Shuo , de Toro Margarita Munoz , Xing Fei , Ruiz Jimmy , Gurcan Metin N. , Li Wencheng , Niazi M. Khalid Khan
Published: September 2024

Lung cancer is the leading cause of cancer-related death in the United States. Lung adenocarcinoma (LUAD) is one of the most common subtypes of lung cancer that can be treated with resection. While resection can be curative, there is a significant risk of recurrence, which necessitates close monitoring and additional treatment planning. Traditionally, microscopic evaluation of tumor grading in resected specimens is a standard pathologic practice that informs subsequent therapy and patient management. However, this approach is labor-intensive and subject to inter-observer variability. To address the challenge of accurately predicting recurrence, we propose a deep learning-based model to predict the 5-year recurrence of LUAD in patients following surgical resection. In our model, we introduce an innovative dual-attention architecture that significantly enhances computational efficiency. Our model demonstrates excellent performance in recurrent risk stratification, achieving a hazard ratio of 2.29 (95% CI: 1.69–3.09, p < 0.005), which outperforms several existing deep learning methods. This study contributes to ongoing efforts to use deep learning models for automatically learning histologic patterns from whole slide images (WSIs) and predicting LUAD recurrence risk, thereby improving the accuracy and efficiency of treatment decision making.
Developmental Therapeutics in Metastatic Prostate Cancer: New Targets and New Strategies
Authors: Zhang Jingsong , Chadha Juskaran S.
Published: September 2024

There is an unmet need to develop new treatments for metastatic prostate cancer. With the development of targeted radioligand therapies, bispecific T cell engagers, antibody–drug conjugates and chimeric antigen receptor T cell (CAR T) therapies, tumor-associated cell surface antigens have emerged as new therapeutic targets in metastatic prostate cancer. Ongoing and completed clinical trials targeting prostate-specific membrane antigen (PSMA), six transmembrane epithelial antigens of the prostate 1 (STEAP1), kallikrein-related peptidase 2 (KLK2), prostate stem cell antigen (PSCA), and delta-like protein 3 (DLL3) in metastatic prostate cancer were reviewed. Strategies for sequential or combinational therapy were discussed.
An Essential Role for Calnexin in ER-Phagy and the Unfolded Protein Response
Authors: Wolf Daniel , Röder Chiara , Sendtner Michael , Lüningschrör Patrick
Published: September 2024

ER-phagy is a specialized form of autophagy, defined by the lysosomal degradation of ER subdomains. ER-phagy has been implicated in relieving the ER from misfolded proteins during ER stress upon activation of the unfolded protein response (UPR). Here, we identified an essential role for the ER chaperone calnexin in regulating ER-phagy and the UPR in neurons. We showed that chemical induction of ER stress triggers ER-phagy in the somata and axons of primary cultured motoneurons. Under basal conditions, the depletion of calnexin leads to an enhanced ER-phagy in axons. However, upon ER stress induction, ER-phagy did not further increase in calnexin-deficient motoneurons. In addition to increased ER-phagy under basal conditions, we also detected an elevated proteasomal turnover of insoluble proteins, suggesting enhanced protein degradation by default. Surprisingly, we detected a diminished UPR in calnexin-deficient early cortical neurons under ER stress conditions. In summary, our data suggest a central role for calnexin in orchestrating both ER-phagy and the UPR to maintain protein homeostasis within the ER.
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases
Authors: Omolekan Tolulope O. , Chamcheu Jean Christopher , Buerger Claudia , Huang Shile
Published: September 2024

Transduction of molecular signaling is a fundamental mechanism that allows a living cell to communicate internally with other cells and its environment through chemical or physical signals, thereby maintaining its structural integrity and triggering physiological responses [...]
Administration of Nitrous Oxide by Medical Assistants for Painful Procedures in Outpatient Pediatric Settings
Authors: Balice-Bourgois Colette , Anselmi Luciano , Schild Barbara , Zumstein-Shaha Maya , Mendoza-Sagaon Mario
Published: September 2024

Background: Managing pain and distress in children experiencing procedural pain is a priority in pediatric care. Nitrous oxide (pre-mixed formulation of 50% nitrous oxide to 50% oxygen) is widely used to alleviate anxiety or pain during care procedures in various medical domains. This pharmacological intervention is safe to administer to children. Administration by non-anesthesiologist personnel is widespread throughout the world, though it is almost exclusively performed by doctors and nurses. The purpose of this study is to describe the experience of nitrous oxide (N2O) use by medical assistants and safe handling during the performance of painful procedures. Methods: A retrospective study was conducted in a pediatric outpatient unit of a regional hospital, including medical and surgical consultations. Results: Nitrous oxide was administered by medical assistants to 324 children aged 3 to 19 years. No respiratory and/or cardiovascular problems were noted. Most patients were calm and relaxed. Discussion: The use of N2O for minor procedures in children in a pediatric outpatient unit improved pain management through administration by medical assistants with a high level of satisfaction from patients, parents and health professionals. Conclusions: This study suggests that the use of nitrous oxide by trained medical assistants can be safe, feasible and effective within the specific context of this study.
Oxygen Vacancy Engineering and Its Impact on Resistive Switching of Oxide Thin Films for Memory and Neuromorphic Applications
Authors: Jana Biswajit , Roy Chaudhuri Ayan
Published: September 2024

Oxygen vacancy engineering in metal oxides is a propitious route to modulate their resistive switching properties for memory and neuromorphic applications. This review provides an account of the research works on tailoring RS behavior in oxide thin-film-based memristor devices by oxygen vacancy engineering. We discuss the recent research progress on controlling oxygen vacancy concentration in metal oxide thin films and its impact on their resistive switching properties for application in electronic memory and neuromorphic computing devices.
Research Progress on the Application of One-Step Fabrication Techniques for Iridium-Based Thin Films in the Oxygen Evolution Reaction
Authors: Li Wenting , Zhu Junyu , Cai Hongzhong , Tong Zhongqiu , Wang Xian , Wei Yan , Wang Xingqiang , Hu Changyi , Zhao Xingdong , Zhang Xuxiang
Published: September 2024

Electrochemical water splitting, a sustainable method for hydrogen production, faces the challenge of slow oxygen evolution reaction (OER) kinetics. Iridium oxide (IrO2) is widely regarded as the most effective catalyst for OER due to its excellent properties. Compared to nanoparticles, IrO2 thin films exhibit significant advantages in OER, including a uniform and stable catalytic interface and excellent mechanical strength. This paper reviews recent advancements in one-step deposition techniques for the preparation of IrO2 thin films and their application in OER. Additionally, it analyzes the advantages and disadvantages of various methods and the latest research achievements, and briefly outlines the future trends and applications.
Study of Probiotic Bacteria Encapsulation for Potential Application in Enrichment of Fermented Beverage
Authors: Madybekova Galiya , Turkeyeva Elmira , Mutaliyeva Botagoz , Osmanova Dinara , Aidarova Saule , Miller Reinhard , Sharipova Altynai , Issayeva Assem
Published: September 2024

The current work is devoted to the development of probiotic microencapsulation systems with the co-encapsulation of a plant extract, which can increase the survival of beneficial bacteria and are suitable for potential applications in the enrichment of fermented beverages based on acid whey. The encapsulation process exhibited a high level of effectiveness, achieving 83.0% for Bifidobacterium (BB), 89.2% for Stevia leaf extract (SE), and 91.3% for their combination (BB + SE). The FTIR analysis verified substantial interactions between the encapsulated agents and the polymer matrix, which enhanced the stability of the microcapsules. The BB + SE microcapsules exhibited reduced swelling and moisture content, indicating a denser structure compared to separately encapsulated BB and SE. Comparison of release kinetics of BB, SE and BB + SE loaded microcapsules showed that the combination of active agents has a quicker initial release, reaching 60% release within the first 2 h, and this value increased to 70% after 4 h. The release kinetics studies demonstrated a controlled release of active substances over 24 h. A morphology analysis shows that the surfaces of the dry microcapsules containing BB, SE, and their combination BB + SE have a porous structure. For encapsulated agents, the size of the capsules produced with BB and SE are smaller than those produced with two components (BB + SE), the sizes of which are between 760 µm and 1.1 mm. Modeling of the behavior of microcapsules in a simulated gastrointestinal tract provides information on swelling and active agents release rates as a function of pH in real biological environments. Thus, the new formulations of microcapsules with microorganisms and plant extracts have great potential for the development of fermented whey-based beverages.
Pre-Crop and Residue Management Effects on Photosynthesis Efficiency and Grain Yield of Dryland Wheat Genotypes
Authors: Lotfi Ramin , Golkari Saber , Abbasi Amin , Rahimzadeh Reza , Mohammadzadeh Arash , Pessarakli Mohammad
Published: September 2024

To evaluate dryland wheat genotypes’ performance under different pre-crop and residue managements under dryland conditions, a split–split plot experiment based on the RCB design, with three replications, was conducted for two years (2017–2018 and 2018–2019). The site of the study has a long-term average precipitation, temperature, and relative humidity of 376 mm, 9 °C, and 50%, respectively. Wheat–wheat and vetch–wheat cropping systems were considered in the main plots, different wheat and vetch residue levels, including 0, 2, and 4 t ha−1, were located in the subplots, and five dryland wheat genotypes, including Sadra, Hashtroud, Baran, Varan, and Ohadi, were allocated in the sub-sub plots. The results indicated that the leaf chlorophyll content index (CCI) and stomatal conductance (gs) were greater in the vetch–wheat cropping system compared to the wheat monoculture system for all genotypes. The normalized difference vegetation index (NDVI) of the genotypes improved by applying the crop residue. Over two years, the application of crop residues resulted in higher variable fluorescence at the J and I steps, as well as an increase in the photosynthesis performance index (PI). The Varan and Baran genotypes stood out as the superior genotype, exhibiting the highest values in physiological characteristics and grain yield under the application of 4 t ha−1 of vetch residue. The grain-filling rate (GFR) was reduced, while the grain-filling duration (GFD) was increased with increasing the crop residue levels. The enhanced grain yield of the wheat genotypes grown under vetch residue was attributed to factors such as improvement in leave pigments and photosynthetic efficiency, which facilitate longer grain filling duration, with high grain weight. As a result, it is advisable to adopt a vetch–wheat cropping system with a high proportion of crop residue in dryland regions to achieve increased and sustainable wheat production.
Fabrication and Characterization of Fe-Doped SnSe Flakes Using Chemical Vapor Deposition
Authors: Sava Florinel , Mihai Claudia , Buruiana Angel-Theodor , Bocirnea Amelia Elena , Velea Alin
Published: September 2024

The development of two-dimensional (2D) materials has gained significant attention due to their unique properties and potential applications in advanced electronics. This study investigates the fabrication and characterization of Fe-doped SnSe semiconductors using an optimized chemical vapor deposition (CVD) method. Fe doping was achieved by dissolving FeCl3 in deionized water, applying it to SnSe powder, and conducting vacuum drying followed by high-temperature CVD at 820 °C. Structural and morphological properties were characterized using optical microscopy, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDX). Results revealed differently shaped flakes, including rectangles, discs and wires, influenced by Fe content. Micro-Raman spectroscopy showed significant vibrational mode shifts, indicating structural changes. X-ray photoelectron spectroscopy (XPS) confirmed the presence of Sn-Se and Fe-Se bonds. Electrical characterization of the memristive devices showed stable switching between high- and low-resistance states, with a threshold voltage of 1.6 V. These findings suggest that Fe-doped SnSe is a promising material for non-volatile memory and neuromorphic computing applications.
The Effects of Light Environment on Adult Odonate Communities in Disturbed and Intact Forest: The Importance of Small-Scale Effects
Authors: Worthen Wade B. , Guevara-Mora Meyer
Published: September 2024

Deforestation in the tropics causes shifts in adult odonate community structure, from forests dominated by thermoconforming zygopteran specialists to open areas with higher representations of heliothermic anisopterans. We tested for these shifts in the Maquina and Cuecha rivers in Monteverde, Costa Rica. We compared adult odonate communities in 100 m plots (subdivided into twenty 5 m subplots) located in disturbed, partially open areas with those in 100 m plots located in intact forest and used general linear models to describe how odonate abundance, species richness, species diversity, and the Anisoptera/Zygoptera ratio varied among plots, subplots, habitat type (disturbed/forested), rivers, and as functions of percent canopy cover and light levels. Plots varied in light levels and percent canopy cover, but there were no significant differences in species richness or diversity. Community composition, however, varied across plots and subplots in NMDS and PERMANOVA analyses, largely as a consequence of the preference of Hetaerina cruentata and Paltothemis lineatipes for high light subplots and H. majuscula for low light subplots. NMDS axes were significantly correlated with percent canopy cover and light level in subplots, and the Anisoptera/Zygoptera ratio correlated with NMDS axes at both the plot and subplot scales, indicating that the relative abundance of anisopterans did increase with increasing light and decreasing canopy cover. Differences among plots and habitats can largely be attributed to species-specific differences in habitat selection at a small spatial scale, causing predicted shifts in the Anisoptera/Zygoptera ratio as dominance shifts from endemic forest species to wide-ranging generalists. This is one of the first studies that confirms these patterns for a cloud forest community.
Impact of Structured Reporting of Lower Extremity CT Angiography on Report Quality and Workflow Efficiency
Authors: Melzig Claudius , Mayer Victoria , Moll Martin , Naas Omar , Hartmann Sibylle , Do Thuy Duong , Kauczor Hans-Ulrich , Rengier Fabian
Published: September 2024

We assessed the effects of structured reporting (SR) of lower extremity CT angiography (CTA) on report quality and workflow efficiency compared with conventional reports (CR). Surveys were conducted at an academic radiology department before and after the introduction of an SR template. Participants (n = 39, 21) rated report quality and report creation effort (1: very dissatisfied/low to 10: very satisfied/high) and whether SR represents an improvement over CR (1: completely disagree to 5: completely agree). Four residents and two supervising radiologists created both CR and SR of 40 CTA examinations. Report creation time was measured and the factual accuracy of residents’ reports was judged. Report completeness (median 8.0 vs. 7.0, p = 0.016) and clinical usefulness (7.0 vs. 4.0, p = 0.029) were rated higher for SR. Supervising radiologists found report clarity improved by SR (8.0 vs. 4.5, p = 0.029). Report creation effort was unchanged (7.0 vs. 6.0, p > 0.05). SR was considered an improvement over CR (median 4.0, IQR,3.0–5.0). Report supervision was shortened by SR (6.2 ± 2.0 min vs. 10.6 ± 3.5 min, p < 0.001) but total time for report creation remained unchanged (36.6 ± 12.8 min vs. 36.4 ± 11.0 min, p > 0.05). Factual accuracy of residents’ SR was deemed higher (8.0/9.5 vs. 7.0/7.0, p = 0.006/ < 0.001). In conclusion, SR has the potential to improve report quality and workflow efficiency for lower extremity CTA.
Design Optimisation of a Flat-Panel, Limited-Angle TOF-PET Scanner: A Simulation Study
Authors: Orehar Matic , Dolenec Rok , El Fakhri Georges , Korpar Samo , Križan Peter , Razdevšek Gašper , Marin Thibault , Žontar Dejan , Pestotnik Rok
Published: September 2024

In time-of-flight positron emission tomography (TOF-PET), a coincidence time resolution (CTR) below 100 ps reduces the angular coverage requirements and, thus, the geometric constraints of the scanner design. Among other possibilities, this opens the possibility of using flat-panel PET detectors. Such a design would be more cost-accessible and compact and allow for a higher degree of modularity than a conventional ring scanner. However, achieving adequate CTR is a considerable challenge and requires improvements at every level of detection. Based on recent results in the ongoing development of optimised TOF-PET photodetectors and electronics, we expect that within a few years, a CTR of about 75 ps will be be achievable at the system level. In this work, flat-panel scanners with four panels and various design parameters were simulated, assessed and compared to a reference scanner based on the Siemens Biograph Vision using NEMA NU 2-2018 metrics. Point sources were also simulated, and a method for evaluating spatial resolution that is more appropriate for flat-panel geometry is presented. We also studied the effects of crystal readout strategies, comparing single-crystal and module readout levels. The results demonstrate that with a CTR below 100 ps, a flat-panel scanner can achieve image quality comparable to that of a reference clinical scanner, with considerable savings in scintillator material.
Cardiac Autonomic Neuropathy Is Not Associated with Apolipoprotein E Gene Isoforms in the Kazakh Population: A Case–Control Study
Authors: Bekenova Nazira , Aitkaliyev Alisher , Vochshenkova Tamara , Kassiyeva Balzhan , Benberin Valeriy
Published: September 2024

The absence of an early diagnosis of cardiac autonomic neuropathy might increase the risk of the disease, progressing to an irreversible stage. Therefore, this study aims to investigate the APOE gene isoforms in patients with cardiac autonomic neuropathy to identify early markers for predicting this disease in the Kazakh population. A total of 147 patients with cardiac neuropathy and 153 controls were examined in this case–control study. Patients were genotyped for two polymorphisms of the APOE gene using real-time PCR. Statistical calculations were performed using binary logistic regression. As a result of our study, we found that there was no statistically significant difference in the frequency of any APOE gene isoforms (APOE (ε2/ε2), APOE (ε2/ε3), APOE (ε2/ε4), APOE (ε3/ε3), or APOE (ε4/ε4)) between the patient group and the control group (p = 0.69, p = 0.64, p = 0.19, p = 0.22, p = 0.97, respectively). Thus, cardiac autonomic neuropathy is not associated with APOE gene isoforms in the Kazakh population.
Quality of Dietetic Patient Education Materials for Diabetes and Gastrointestinal Disorders: Where Can We Do Better?
Authors: Lambert Kelly , Hodgson Olivia , Goodman Claudia
Published: September 2024

(1) Background: Patient education materials are frequently used by dietitians to support counselling and reinforce key concepts. No studies have examined the quality of dietetic patient education materials for diabetes and common gastrointestinal conditions. (2) Methods: Materials relating to the dietary management of diabetes and gastrointestinal conditions (IBD, IBS, lactose intolerance, coeliac disease and low-FODMAP diets) were evaluated by three dietitian raters. Readability was assessed, and materials with a reading grade level ≤ 7 were considered readable. The PEMAT was used to assess understandability and actionability. Clarity was determined using the CDCCCI. (3) Results: Overall readability scores were satisfactory with a median grade level of 6 (IQR: 5–8). Readability scores did not differ between material types (p = 0.09). The health literacy demand of materials was suboptimal, with a mean understandability score of 65.9 ± 15.1% and an actionability score 49.6% ± 20.8%. Both scores fell below the benchmark of ≥70%. These did not differ between material types (p = 0.06 and p = 0.15, respectively). Clarity scores were below the benchmark of ≥90% (mean score 64.2 ± 14.8%). Only 6.6% of materials achieved a score of ≥90. (4) Conclusions: Improvements to the health literacy demand and clarity of dietetic patient education materials are required. Areas for future improvement have been identified.
Natural Induction: Spontaneous Adaptive Organisation without Natural Selection
Authors: Buckley Christopher L. , Lewens Tim , Levin Michael , Millidge Beren , Tschantz Alexander , Watson Richard A.
Published: September 2024

Evolution by natural selection is believed to be the only possible source of spontaneous adaptive organisation in the natural world. This places strict limits on the kinds of systems that can exhibit adaptation spontaneously, i.e., without design. Physical systems can show some properties relevant to adaptation without natural selection or design. (1) The relaxation, or local energy minimisation, of a physical system constitutes a natural form of optimisation insomuch as it finds locally optimal solutions to the frustrated forces acting on it or between its components. (2) When internal structure ‘gives way’ or accommodates a pattern of forcing on a system, this constitutes learning insomuch, as it can store, recall, and generalise past configurations. Both these effects are quite natural and general, but in themselves insufficient to constitute non-trivial adaptation. However, here we show that the recurrent interaction of physical optimisation and physical learning together results in significant spontaneous adaptive organisation. We call this adaptation by natural induction. The effect occurs in dynamical systems described by a network of viscoelastic connections subject to occasional disturbances. When the internal structure of such a system accommodates slowly across many disturbances and relaxations, it spontaneously learns to preferentially visit solutions of increasingly greater quality (exceptionally low energy). We show that adaptation by natural induction thus produces network organisations that improve problem-solving competency with experience (without supervised training or system-level reward). We note that the conditions for adaptation by natural induction, and its adaptive competency, are different from those of natural selection. We therefore suggest that natural selection is not the only possible source of spontaneous adaptive organisation in the natural world.
Support Vector Machine Algorithm for Mapping Land Cover Dynamics in Senegal, West Africa, Using Earth Observation Data
Authors: Lemenkova Polina
Published: September 2024

This paper addresses the problem of mapping land cover types in Senegal and recognition of vegetation systems in the Saloum River Delta on the satellite images. Multi-seasonal landscape dynamics were analyzed using Landsat 8-9 OLI/TIRS images from 2015 to 2023. Two image classification methods were compared, and their performance was evaluated in the GRASS GIS software (version 8.4.0, creator: GRASS Development Team, original location: Champaign, Illinois, USA, currently multinational project) by means of unsupervised classification using the k-means clustering algorithm and supervised classification using the Support Vector Machine (SVM) algorithm. The land cover types were identified using machine learning (ML)-based analysis of the spectral reflectance of the multispectral images. The results based on the processed multispectral images indicated a decrease in savannas, an increase in croplands and agricultural lands, a decline in forests, and changes to coastal wetlands, including mangroves with high biodiversity. The practical aim is to describe a novel method of creating land cover maps using RS data for each class and to improve accuracy. We accomplish this by calculating the areas occupied by 10 land cover classes within the target area for six consecutive years. Our results indicate that, in comparing the performance of the algorithms, the SVM classification approach increased the accuracy, with 98% of pixels being stable, which shows qualitative improvements in image classification. This paper contributes to the natural resource management and environmental monitoring of Senegal, West Africa, through advanced cartographic methods applied to remote sensing of Earth observation data.
Harnessing Field-Programmable Gate Array-Based Simulation for Enhanced Predictive Control for Voltage Regulation in a DC-DC Boost Converter
Authors: Ríos Sara J. , Sánchez G. Elio , Intriago Andrés , Falcones Síxifo
Published: September 2024

This paper presents the design of a predictive controller for a boost converter and validation through real-time simulation. First, the boost converter was mathematically modeled, and then the electronic components were designed to meet the operation requirements. Subsequently, a model-based predictive controller (MBPC) and a digital PI (Proportional–Integral) controller were designed, and their performance was compared using MATLAB/SIMULINK®. The controls were further verified by implementing test benches based on an FPGA (Field-Programmable Gate Array) with an OPAL-RT real-time simulator, which included the RT-LAB and RT-eFPGAsim simulation packages. These tests were successfully carried out, and the methodology used for this design was validated. The results showed a better response obtained with MBPC, both in terms of stabilization time and lower overvoltage.
Comparison of Reactive Power Compensation Methods in an Industrial Electrical System with Power Quality Problems
Authors: Giha Yidi Salim Adolfo , Sousa Santos Vladimir , Berdugo Sarmiento Kelly , Candelo-Becerra John E. , de la Cruz Jorge
Published: September 2024

This paper compares concentrated and distributed reactive power compensation to improve the power factor at the point of common connection (PCC) of an industrial electrical system (IES) with harmonics. The electrical system under study has a low power factor, voltage variation, and harmonics caused by motors operating at low loads and powered by variable-speed drives. The designed compensation system mitigates harmonics and reduces electrical losses with the shortest payback period. Four solutions were compared, considering concentrated and distributed compensation with capacitor banks and harmonic filters. Although the cost of investment in concentrated compensation is lower than that of distributed compensation, a higher reduction in electrical losses and a lower payback period are obtained with distributed compensation. Although the lowest payback period was obtained with distributed compensation with capacitor banks (0.4 years), it is not recommended in the presence of harmonics because the effects of current harmonics significantly reduce the useful life of these elements. For this reason, distributed compensation with harmonic filters obtained a payback period of 0.6 years, and it was proposed as the best solution. These results should be considered in projects aimed at power factor compensation in IESs with harmonics. The concentrated compensation of the capacitor bank at the PCC is proposed because of the lower investment cost and ease of installation. However, the advantages of distributed compensation with harmonic filters have not been evaluated. An energy efficiency approach is used to analyze the impact of the location methods of the power factor compensation equipment on the electrical losses of the IES.