bluuebunny/crossref_metadata_2025 huggingface dataset:
A mixed-methods study evaluating the impact of an excursion-based social group on quality of life of older adults
Authors: Siette Joyce , Jorgensen Mikaela , Nguyen Amy , Knaggs Gilbert , Miller Stuart , Westbrook Johanna I.
Published: June 2021

Background

Social isolation is an increasing concern for older adults who live in the community. Despite some availability of social support programs to address social isolation, their effectiveness is not routinely measured. This study aimed to evaluate an innovative excursion-based program offering unique social experiences to older adults receiving aged care services.

Methods

This six-month before and after mixed-methods study evaluated the outcomes of an Australian excursion-based program which offered social and physical outings to bring older adults receiving aged care services into the wider community. The study combined two parts: Part 1 was a pre-post survey assessing the quality of life of older adults who received the excursion-based program for 6 months (n = 56; two time-points, analysed using signed rank test) and Part 2 involved qualitative in-depth, semi-structured interviews (n = 24 aged care staff, older adults and carers; analysed using thematic analysis).

Results

Older adults experienced a significant increase in quality of life scores (p < 0.001) between baseline and 6 months. Interviews confirmed these observations and suggested that benefits of participation included increased opportunities for social participation, psychological wellbeing, physical function, and carer respite. Interviews also revealed being in a group setting, having tailored, convenient and accessible activities, alongside supportive staff were key drivers in improving the wellbeing of participants.

Conclusions

Participating in an excursion-based community program may improve wellbeing in older adults. Aging policy should focus on prioritizing initiatives that promote social connectivity with the wider community and assist in improving outcomes for older adults.
Tobacco use in the Myeloproliferative neoplasms: symptom burden, patient opinions, and care
Authors: Christensen Sarah F. , Scherber Robyn M. , Mazza Gina L. , Dueck Amylou C. , Brochmann Nana , Andersen Christen L. , Hasselbalch Hans C. , Mesa Ruben A. , Geyer Holly L.
Published: June 2021

Background

Patients with Philadelphia-negative Myeloproliferative Neoplasms (MPN) suffer from numerous symptoms and decreased quality of life. Smoking is associated with an increased symptom burden in several malignancies. The aim of this study was to analyze the association between smoking and MPN-related symptom burden and explore MPN patients’ opinions on smoking.

Methods

A total of 435 patients with MPN participated in a cross-sectional internet-based survey developed by the Mayo Clinic and the Myeloproliferative Neoplasm Quality of Life Group. Patients reported their demographics, disease characteristics, tobacco use, and opinions on tobacco use. In addition, MPN-related symptoms were reported via the validated 10-item version of the Myeloproliferative Neoplasms Symptom Assessment Form.

Results

Current/former smokers reported worse fatigue (mean severity 5.6 vs. 5.0, p = 0.02) and inactivity (mean severity 4.0 vs. 3.4, p = 0.03) than never smokers. Moreover, current/former smokers more frequently experienced early satiety (68.5% vs. 58.3%, p = 0.03), inactivity (79.9% vs. 71.1%, p = 0.04), and concentration difficulties (82.1% vs. 73.1%, p = 0.04). Although not significant, a higher total symptom burden was observed for current/former smokers (mean 30.4 vs. 27.0, p = 0.07). Accordingly, overall quality of life was significantly better among never smokers than current/former smokers (mean 3.5 vs. 3.9, p = 0.03). Only 43.2% of the current/former smokers reported having discussed tobacco use with their physician, and 17.5% did not believe smoking increased the risk of thrombosis.

Conclusion

The current study suggests that smoking may be associated with increased prevalence and severity of MPN symptoms and underscores the need to enhance patient education and address tobacco use in the care of MPN patients.
A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis
Authors: Qu Siming , Jin Li , Huang Hanfei , Lin Jie , Gao Weiwu , Zeng Zhong
Published: June 2021

Background

Hepatitis B Virus (HBV) contributes to liver carcinogenesis via various epigenetic mechanisms. The newly defined epigenetics, epitranscriptomics regulation, has been reported to involve in multiple cancers including Hepatocellular Carcinoma (HCC). Our previous study found that HBx, HBV encodes X protein, mediated H3K4me3 modification in WDR5-dependent manner to involve in HBV infection and contribute to oncogene expression. AlkB Homolog 5 (ALKBH5), one of epitranscriptomics enzymes, has been identified to be associated with various cancers. However, whether and how ALKBH5 is dysregulated in HBV-related HCC remains unclear yet. This study aims to investigate ALKBH5 function, clinical significance and mechanism in HBV related HCC (HBV-HCC) patients derived from Chinese people.

Methods

The expression pattern of ALKBH5 was evaluated by RT-qPCR, Western blot, data mining and immunohistochemistry in total of 373 HBV-HCC tissues and four HCC cell lines. Cell Counting Kit 8 (CCK8) assay, Transwell and nude mouse model were performed to assess ALKBH5 function by both small interference RNAs and lentiviral particles. The regulation mechanism of ALKBH5 was determined in HBx and WDR5 knockdown cells by CHIP-qPCR. The role of ALKBH5 in HBx mRNA N6-methyladenosine (m6A) modification was further evaluated by MeRIP-qPCR and Actinomycin D inhibitor experiment in HBV-driven cells and HBx overexpression cells.

Result

ALKBH5 increased in tumor tissues and predicts a poor prognosis of HBV-HCC. Mechanically, the highly expressed ALKBH5 is induced by HBx-mediated H3K4me3 modification of ALKBH5 gene promoter in a WDR5-dependent manner after HBV infection. The increased ALKBH5 protein catalyzes the m6A demethylation of HBx mRNA, thus stabilizing and favoring a higher HBx expression level. Furthermore, there are positive correlations between HBx and ALKBH5 in HBV-HCC tissues, and depletion of ALKBH5 significantly inhibits HBV-driven tumor cells’ growth and migration in vitro and in vivo.

Conclusions

HBx-ALKBH5 may form a positive-feedback loop to involve in the HBV-induced liver carcinogenesis, and targeting the loop at ALKBH5 may provide a potential way for HBV-HCC treatment.
Reaching early adolescents with a complex intervention for HIV prevention: findings from a cohort study to evaluate DREAMS in two informal settlements in Nairobi, Kenya
Authors: Mulwa Sarah , Osindo Jane , Wambiya Elvis O. , Gourlay Annabelle , Maina Beatrice W. , Orindi Benedict O. , Floyd Sian , Ziraba Abdhalah , Birdthistle Isolde
Published: June 2021

Background

The DREAMS Partnership promotes combination HIV prevention among adolescent girls and young women. We examined the extent to which DREAMS interventions reached early adolescent girls (EAG; aged 10–14 years) in two informal settlements in Nairobi, and the characteristics of those reached, after 3 years of implementation.

Methods

We utilized three data rounds from a randomly-sampled cohort of EAG established in 2017 in Korogocho and Viwandani informal settlements where DREAMS interventions were implemented. Interventions were classified as individual or contextual-level, with individual interventions further categorised as primary (prioritised for this age group), or secondary. We summarised self-reported invitation to participate in DREAMS, and uptake of eight interventions that were supported by DREAMS, during 2017–2019. Multivariable logistic regression analysis was used to identify individual and household characteristics associated with invitation to DREAMS and uptake of primary interventions.

Results

Data were available for 606, 516 (retention rate of 85%) and 494 (82%) EAG in 2017, 2018 and 2019, respectively. Proportions invited to DREAMS increased from 49% in 2017, to 77% by 2018, and to 88% by 2019. School-based HIV and violence prevention, and HIV testing and counselling were the most accessed interventions (both at 82%). Cumulative uptake of interventions was higher among those invited to participate in DREAMS compared to those never invited, particularly for new interventions such as social asset building and financial capability training. Contextual-level interventions were accessed infrequently. Most of those invited both in 2017 and 2018 accessed ≥3 interventions (96%), and 55% received all three primary interventions by 2019.

Conclusions

Uptake of DREAMS interventions among a representative sample of EAG was high and quickly increased over the implementation period. The majority accessed multiple interventions, indicating that it is feasible to integrate and deliver a package of interventions to EAG in a challenging informal context.
Fostering cardiovascular health at work – case study from Senegal
Authors: Ndione Ida , Aerts Ann , Barshilia Asha , Boch Johannes , Rosiers Sarah Des , Ferrer Jose M. E. , Saric Jasmina , Seck Karim , Sene Bernard N. , Steinmann Peter , Venkitachalam Lakshmi , Shellaby Jason T.
Published: June 2021

Background

Of the 15 million annual premature deaths from non-communicable diseases (NCDs), 85% occur in low- and middle-income countries (LMICs). Affecting individuals in the prime of their lives, NCDs impose severe economic damage to economies and businesses, owing to the high mortality and morbidity within the workforce. The Novartis Foundation urban health initiative, Better Hearts Better Cities, was designed to improve cardiovascular health in Dakar, Senegal through a combination of interventions including a workplace health program. In this study, we describe the labor policy environment in Senegal and the outcomes of a Novartis Foundation-supported multisector workplace health coalition bringing together volunteering private companies.

Methods

A mixed method design was applied between April 2018 and February 2020 to evaluate the workplace health program as a case study. Qualitative methods included a desk review of documents relevant to the Senegalese employment context and work environment and in-depth interviews with eight key informants including human resource representatives and physicians working in the participating companies. Quantitative methods involved an analysis of workplace health program indicators, including data on diagnosis, treatment and control of hypertension in employees, provided by the coalition companies, and a cost estimate of NCD-related ill-health as compared to the investment needed for hypertension screening and awareness raising events.

Results

Senegal has a legal and regulatory system that ensures employee protection, supports social security benefits, and promotes health and hygiene in companies. The Dakar Workplace Health Coalition comprised 18 companies, with a range of staff between 300 and 4′220, covering 36′268 employees in total. Interviews suggested that the main enablers for workplace program success were strong leadership support within the company and a central coordination mechanism for the program. The main barrier to monitor progress and outcomes was the reluctance of companies to share data. Four companies provided aggregated anonymized cohort data, documenting a total of 21′392 hypertension screenings and an increasing trend in blood pressure control (from 34% in Q4 2018 to 39% in Q2 2019) in employees who received antihypertensive treatment.

Conclusion

Evidence on workplace health and wellness programs in Africa is scarce. This study highlights how private sector companies can play a significant role in improving cardiovascular population health in LMICs.
Health literacy, health perception and related factors among different ethnic groups: a cross-sectional study in southeastern Turkey
Authors: Yiğitalp Gülhan , Bayram Değer Vasfiye , Çifçi Sema
Published: June 2021

Background

Low levels of health literacy are associated with increased hospitalization rates, problems regarding the proper intake of medications, poor general health and increased mortality rates. It is a well-known fact that health literacy differs among ethnic groups and ethnic minorities, in particular, are known to have a low level of health literacy. The present study aimed to reveal the levels of health literacy among different ethnic groups and the affecting factors as well as the relationship between health literacy and health perceptions.

Methods

This cross-sectional study was carried out with different ethnic groups (Kurdish, Arab, Turkish and Assyrian origin), between 18 and 65 years old in the province of Mardin in Turkey. The study was conducted with a total of 600 people. The European Health Literacy Scale-Turkish Adaptation (EHLS-TR) and Health Perception Scale (HPS) were used for measurement. Descriptive analysis, Mann Whitney U Test, Kruskal Wallis Test and Spearman correlation were used in the data analysis.

Results

It was found that 80.7% of the participants had relatively low levels of health literacy. The lowest levels of health literacy were among those of Kurdish origin. There were correlations between sufficient levels of health literacy and several factors including being of Assyrian origin, being 50–65 years old, living in a nuclear family, being a secondary school graduate, having a high financial status, being retired, evaluating one’s own health status as good, obtaining health information from healthcare professionals, preferring to visit a state hospital to seek medical assistance first, smoking and drinking alcohol. A positive correlation was also identified between the levels of health literacy and health perception.

Conclusions

It is essential to develop programs to increase health literacy for the public and, in particular, for the ethnic groups that are disadvantaged in many aspects in the context of health literacy.
NAPG mutation in family members with hereditary hemorrhagic telangiectasia in China
Authors: Xu Yu , Zhang Yong-Biao , Liang Li-Jun , Tian Jia-Li , Lin Jin-Ming , Wang Pan-Pan , Li Rong-Hui , Gu Ming-Liang , Gao Zhan-Cheng
Published: June 2021

Background

Hereditary hemorrhagic telangiectasia (HHT) is a disease characterized by arteriovenous malformations in the skin and mucous membranes. We enrolled a large pedigree comprising 32 living members, and screened for mutations responsible for HHT.

Methods

We performed whole-exome sequencing to identify novel mutations in the pedigree after excluding three previously reported HHT-related genes using Sanger sequencing. We then performed in silico functional analysis of candidate mutations that were obtained using a variant filtering strategy to identify mutations responsible for HHT.

Results

After screening the HHT-related genes, activin A receptor-like type 1 (ACVRL1), endoglin (ENG), and SMAD family member 4 (SMAD4), we did not detect any co-segregated mutations in this pedigree. Whole-exome sequencing analysis of 7 members and Sanger sequencing analysis of 16 additional members identified a mutation (c.784A > G) in the NSF attachment protein gamma (NAPG) gene that co-segregated with the disease. Functional prediction showed that the mutation was deleterious and might change the conformational stability of the NAPG protein.

Conclusions

NAPG c.784A > G may potentially lead to HHT. These results expand the current understanding of the genetic contributions to HHT pathogenesis.
CTCs detection from intraoperative salvaged blood in RCC–IVC thrombus patients by negative enrichment and iFISH identification: a preliminary study
Authors: Zhang Xiaoqing , Guo Xiangyang , Zong Yanan , Xu Chuanya , Wang Jilian , Zhang Bin , Liu Chang , Gong Yueqing , Xue Lixiang , Ma Lulin , Zhang Shudong , Li Yi , Zeng Hong
Published: June 2021

Background

Intra-operative cell salvage (IOCS) and leukocyte-depleted filter (LDF) are widely used and effective in saving blood. However, the safety issue concerning reinfusion of IOCS–LDF processed blood to renal cell carcinoma (RCC) patients with inferior vena cava (IVC) thrombus were inconclusive for fear of increased risk of cancer metastases. This study intends to analyze the circulating tumor cell (CTC) eliminating effect of IOCS–LDF in 5 RCC–IVC thrombus patients.

Methods

A novel strategy integrating negative enrichment by immunomagnetic beads and immunostaining-fluorescence in situ hybridization with probes identifying aneuploid of 8 and/or 7 were used to detect CTCs from salvages blood. Blood samples were collected from 4 stages in each patient.

Results

Of the 5 RCC patients, the number of CTCs decreased (from 3, 4, 10, 7, 3, respectively, to all zero) after IOCS–LDF treatment. The triploid of chromosome 7 and/or chromosome 8 were most common karyotype for RCC patients with IVC thrombus. Tetraploid of chromosome 8 occurred in only one sample and no polypoid (number of chromosome > 4) were found.

Conclusion

IOCS–LDF might be a promising way of reducing of allogeneic product transfusion based on current preliminary outcome. More convincing conclusions are to be drawn with enlarged sample size and long-term follow-up for patients prognosis.
Prophylactic transcatheter arterial embolization for high-risk ulcers following endoscopic hemostasis: a meta-analysis
Authors: Yu Qian , Liu Chenyu , Collura Biagio , Navuluri Rakesh , Patel Mikin , Yu Zhiyong , Ahmed Osman
Published: June 2021

Background

To conduct a meta-analysis to assess the safety and efficacy of prophylactic transcatheter arterial embolization (PTAE) for the treatment of high-risk bleeding peptic ulcers after achieving endoscopic hemostasis.

Methods

PubMed and Cochrane Library were queried for full-text articles published up to December 2019. The following keywords were used: “prophylactic embolization”, “supplement embolization”, “gastrointestinal bleeding”, and “ulcer bleeding”. High-risk ulcers were defined based on endoscopic findings (i.e., large ulcers, Forrest class I-IIb) and/or clinical presentation (i.e., hypotension, decreased hemoglobin during endoscopy). Only comparative studies investigating PTAE versus conservative treatment after achieving endoscopic hemostasis were included. Baseline study characteristics, rebleeding rate, need for surgery, mortality, and PTAE-related complication rates were investigated. Quantitative analyses were performed with Stata 15.1.

Results

Among the five included original studies, a total of 265 patients received PTAE and 617 were managed conservatively after endoscopy. The rebleeding rate (6.8% vs 14.3%, p = 0.003) and mortality (4.5% vs 8.8%, p = 0.032) of patients from the PTAE group were lower than the control group. PTAE also reduced the cumulative need for future surgical intervention (3.0% vs 14.4%, p = 0.005). The PTAE-related major and minor events were 0.75% and 14.4%, respectively.

Conclusion

PTAE had therapeutic potentials in reducing rebleeding risk, need for surgical intervention, and morality in high-risk peptic ulcers after achieving endoscopic hemostasis. The embolization-associated adverse events were minimal. Future studies should aim to increase the sample size and resources for performing endovascular interventions.
Relationship of the knee extensor strength but not the quadriceps femoris muscularity with sprint performance in sprinters: a reexamination and extension
Authors: Hori Miyuki , Suga Tadashi , Terada Masafumi , Tanaka Takahiro , Kusagawa Yuki , Otsuka Mitsuo , Nagano Akinori , Isaka Tadao
Published: June 2021

Purpose

This study examined the relationships of knee extensor strength and quadriceps femoris size with sprint performance in sprinters.

Methods

Fifty-eight male sprinters and 40 body size-matched male non-sprinters participated in this study. The knee extensor isometric and isokinetic strengths were measured using a dynamometer. The isokinetic strength measurements were performed with slow and fast velocities at 60°/s and 180°/s, respectively. The quadriceps femoris muscle volume (MV) was measured using magnetic resonance imaging. The relative knee extensor strengths and quadriceps femoris MV were calculated by normalizing to body mass.

Results

Absolute and relative knee extensor strengths during two velocity isokinetic contractions, but not during isometric contraction, were significantly higher in sprinters than in non-sprinters (P = 0.047 to < 0.001 for all). Such a significant difference was also observed for relative quadriceps femoris MV (P = 0.018). In sprinters, there were positive correlations between all three knee extensor strengths and quadriceps femoris MV (r = 0.421 to 0.531, P = 0.001 to < 0.001 for all). The absolute and relative strengths of the fast-velocity isokinetic knee extension correlated negatively with personal best 100-m sprint time (r = −0.477 and −0.409, P = 0.001 and < 0.001, respectively). In contrast, no such significant correlations were observed between absolute and relative quadriceps femoris MVs and personal best 100-m sprint time.

Conclusions

These findings suggest that despite the presence of the relationship between muscle strength and size, the knee extensor strength may be related to superior sprint performance in sprinters independently of the quadriceps femoris muscularity.
The development and evaluation of an HIV implementation science network in New England: lessons learned
Authors: van den Berg Jacob J. , O’Keefe Elaine , Davidson Daniel , Fiellin David A. , Kershaw Trace , Barbour Russell C. , Cu-Uvin Susan , Cleary Paul D.
Published: June 2021

Background

Describe and evaluate an implementation science network focused on HIV prevention and treatment in New England.

Methods

In 2014, we established a partnership among university researchers and community stakeholders to stimulate and support HIV-related implementation research. We solicited information from Network members through surveys, interviews at Network events, and dialog with participants. In 2017, we conducted a sociocentric network assessment of collaborations on research projects, grants, manuscripts, and consultations.

Results

We identified 988 connections made through the Network that resulted in 185 manuscripts published and 15 grants funded. Our experience indicated that eight factors were instrumental in building and sustaining the Network: (1) acknowledging different perspectives, (2) balancing content and expertise, (3) encouraging consistent engagement, (4) providing seed funding, (5) membership flexibility, (6) maintenance of Network interactions, (7) supporting local HIV prevention and treatment efforts, and (8) maintaining productive relationships with health departments and community-based organizations.

Conclusions

Developing and maintaining a regional network on implementation science for HIV prevention and treatment is feasible and can facilitate new and productive partnerships among researchers and community organizations and members.
Placebo effects: a new paradigm and relevance to psychiatry
Authors: McQueen Daniel , St John Smith Paul
Published: June 2021

Systematic evaluations show that placebo treatments can have large effects, sometimes larger than those of ‘evidence-based treatments’. This is the ‘efficacy paradox’. The neurobiology of placebo effects is being mapped out. Placebo effects are no less real or, in some illnesses, clinically important than the effects of direct biomechanical or pharmacological interventions. The technical model of medicine seeks impersonal technologies that can be applied independently of context and person. This approach has had spectacular success in the treatment of disease but meaning, cultural context, interpersonal effects, personal preferences and values are enormously important in the treatment of illness. The study of placebo reveals aspects of the biology of interpersonal relationships and the social environment. The evidence demonstrates that interpersonal healing (sometimes called placebo) in illness is just as real, scientific and biological as technological healing. This is a paradigm shift.
Safety and Efficacy of Radiofrequency Ablation of Thyroid Nodules—Expanding Treatment Options in the United States
Authors: Hussain Iram , Zulfiqar Fizza , Li Xilong , Ahmad Shahzad , Aljammal Jules
Published: June 2021

Context

Radiofrequency ablation (RFA) has only recently gained popularity in the United States for treatment of thyroid nodules (TNs), with a limited number of patients having undergone the procedure in this country.

Objective

To evaluate the safety and efficacy of RFA of TNs performed in an outpatient setting in the United States.

Methods

This is a retrospective, single-center study of 53 patients who underwent RFA of 58 TNs between November 2018 and January 2021. The reduction in volume of nodule, cosmetic and symptomatic improvement, effect on thyroid function, and complications following RFA were assessed.

Results

Eleven out of 53 patients were excluded from the analysis. A total of 47 benign TNs (23 nonfunctioning thyroid nodules [NFTNs] and 24 autonomously functioning thyroid nodules [AFTNs]), were assessed after RFA. The median reduction in volume was 70.8% after a median follow-up period of 109 days, with symptomatic and cosmetic improvement (P < 0.0001). Compared with larger nodules, smaller nodules had greater volume reduction (P = 0.0266). RFA improved thyrotropin (TSH) in AFTNs (P value = 0.0015) and did not affect TSH in NFTNs (P value = 0.23). There were no major complications; however, 1 patient had self-limited local bleeding and another had transient voice change that recovered in 6 months.

Conclusion

RFA is a safe and efficacious treatment for symptomatic NFTNs and AFTNs in our population and is especially effective for smaller nodules. RFA should be considered an alternative for TNs in patients who cannot or do not want to undergo surgery.
Nudes and Naked Souls
Authors: Pichon-Rivière Rocío
Published: June 2021

This essay is part of a project historicizing vernacular theories from Latin America to create dialogues across geopolitical and epistemic borders. This article specifically advances a comparatist analysis of the critical phenomenologies of nudity, truth, and social space by two trans thinkers: Marlene Wayar, an Argentine social psychologist and activist, and Talia Mae Bettcher, a Canadian philosopher and activist based in Los Angeles. Pichon-Rivière argues that a core difference between their approaches stems from different geopolitical and disciplinary regimes of visibility and that these paradigms are not as incompatible as they might seem at first glance. Pichon-Rivière's own theorization seeks to integrate these two perspectives into a shared critical phenomenology of collective truth.
Περιβαλλοντικά υπεύθυνη συμπεριφορά στο χώρο εργασίας. Μια προσέγγιση του ρόλου της διεύθυνσης και του εργασιακού κλίματος
Authors: Περατικός Ανδρέας , Κάτζη Χρυσάνθη
Published: June 2021

Μεγάλο μέρος του χρόνου μας αναλώνεται στο χώρο εργασίας με πολλές από τις επαγγελματικές  μας δραστηριότητες να έχουν επιπτώσεις στο περιβάλλον. Είναι επομένως αναγκαία η υιοθέτηση περιβαλλοντικά υπεύθυνης επαγγελματικής συμπεριφοράς (ΠΥΕΣ), για την αντιμετώπιση ζητημάτων που αφορούν το περιβάλλον και την αειφόρο ανάπτυξη. Η υιοθέτηση ΠΥΕΣ δεν εξαρτάται μόνο από την περιβαλλοντικά υπεύθυνη συμπεριφορά (ΠΥΣ) των ατόμων αλλά και από τις συνθήκες στο χώρο εργασίας, σε επίπεδο εταιρικής πολιτικής και ενδο-εταιρικής κουλτούρας. Συνεπώς, επηρεάζεται από σειρά παραγόντων που την ενθαρρύνουν ή την εμποδίζουν, οι οποίοι ρυθμίζονται από τη Διοίκηση μιας εταιρίας. Η παρούσα εργασία μελετά τις αντιλήψεις εργοδοτουμένων σε πράσινους χώρους εργασίας [και μη] και διευθυντικών στελεχών, γύρω από τους παράγοντες και το ρόλο των διευθυντών στην ενίσχυση της ΠΥΕΣ στο χώρο εργασίας. Τα αποτελέσματα καταδεικνύουν ότι η σημασία του ρόλου της διεύθυνσης εντοπίζεται στο παράδειγμα που αυτή θέτει, στο εργασιακό κλίμα που δημιουργεί, στην ενσωμάτωση φιλοπεριβαλλοντικών πρακτικών, στις διαδικασίες και τα πρωτόκολλα εργασίας, την παροχή κινήτρων, καθώς και τη σημασία που αυτή αποδίδει στην εκπαίδευση σε θέματα περιβάλλοντος και αειφορίας στα πλαίσια της επαγγελματικής εκπαίδευσης-κατάρτισης. Οι ερευνητές συζητούν τα αποτελέσματα και προτείνουν μέτρα καλής πρακτικής για την γεφύρωση της απόστασης μεταξύ της πρόθεσης και της εκδήλωσης ΠΥΕΣ.
Βιβλιοπαρουσίαση "Περιβαλλοντική Εκπαίδευση. Ζητήματα Ταυτότητας"
Authors: Περιβαλλοντική Εκπαίδευση για την Αειφορία ΕΛ.Ε.ΕΤ.Π.Ε.Α.
Published: June 2021

Βιβλιοπαρουσίαση
Dispositivo pedagógico da mídia e representações de gênero e sexualidade em: She-Ra and the Princesses of Power
Authors: Almeida Rodrigues Lima Cecília , Costa Marcela , Bernardino Barreto Januário Soraya Maria , Maia Cavalcanti Gêsa Karla , Moreira Gouveia Diego , Oliveira Cancio dos Santos Talitta
Published: June 2021

O presente artigo discute as representações de gênero e sexualidade na série animada She-ra and The Princesses of Power (2018-2020). Para tanto, foi realizada uma pesquisa descritiva e exploratória com fãs do desenho de todo o mundo. A partir de conceitos como dispositivo pedagógico da mídia, gênero, sexualidade e representação, além dos pressupostos metodológicos da Análise de Conteúdo (Bardin, 2011), foi possível compreender o papel da série como instrumento pedagógico capaz de desencadear processos de subjetivação em sua audiência. A análise chegou a três categorias de comentários: conhecimento de si; afirmação de si; legitimação do outro. Narrativas audiovisuais podem legitimar, reiterar e naturalizar comportamentos, práticas e identidades, na maioria das vezes, invisibilizando minorias. She-Ra propõe representações de gênero e sexualidade que subvertem as lógicas heteronormativas e, para os fãs, é isso que faz do desenho tão importante, contribuindo para o entendimento e a legitimação de quem são, além de ensinar novas pedagogias, na contramão do discurso hegemônico ainda disseminado pela mídia.
Cutaneous and Ganglion Sarcoidosis Induced by Polycaprolactone Facial Filler: A New Expression of ASIA Syndrome?
Authors: Ortiz-Álvarez Juan , Lebron-Martin Jose Antonio , Rodriguez Fernandez-Freire Lourdes , Zulueta-Dorado Teresa , Garcia-Morillo Jose Salvador
Published: June 2021

Dermal fillers are applied using a minimally invasive technique with a good safety profile. However, they can have side effects. We present the case of a patient who, 2 months after undergoing polycaprolactone (Ellansé®) injections, developed nodular facial and nodal lesions that were compatible with sarcoidosis on histology. This complication has not been previously described for polycaprolactone and could be the expression of an autoimmune syndrome induced by adjuvants.
BAITUL MAL WAT TANWIL DAN KESEJAHTERAAN MASYARAKAT DI KELURAHAN CIMINCRANG BANDUNG
Authors: Adnani Latifah , Kania Trisa Nur
Published: June 2021

Most of the Cimincrang people originally came from their own fields. In connection with the development of areas that make Cimincrang residents their land must be sold to the government and housing developers because the Cimincrang area will be the center of the administration of the City of Bandung 2 primary and commercial area, so residents can no longer run the agricultural sector. Many residents who turn jobs become traders, motorcycle taxis driver, factory workers, casual daily workers. Due to the increasing needs of the community while the ability of citizens is limited, so to meet their daily needs and to increase business capital, many of them use the services of loan sharks whose loan repayments are considered burdensome. This condition prompted several community leaders in the Cimincrang region to hold a meeting to establish Baitul Mal wat Tamwil Insan Madani (Iman), a microfinance institution helping the people in the economic sector. The purpose of this study is to determine the role of Baitul Mal wat Tamwil (BMT), the welfare of the community in Cimincrang Village, Bandung, and the role of BMT in improving the welfare of the community in Cimincrang Village, Bandung. This study uses a qualitative approach with descriptive methods. Based on the research results, the residents of Cimincrang Urban Village were greatly helped by the presence of the BMT Faith, because they have not been in debt with loan sharks anymore, and funds from BMT are not difficult to obtain, basically trust.
PERAN FINTECH (FINANCIAL TECHNOLOGY) DALAM MENINGKATKAN DAYA SAING PRODUK DI UKM INDUSTRI ALAS KAKI CIBADUYUT KOTA BANDUNG
Authors: Yuniarti Yuyun , Dinihayati Erti
Published: June 2021

Footwear business activities in Cibaduyut, Bandung City are supported by various factors, such as entrepreneurial spirit, facilities, marketing, raw material procurement and capital procurement. This research is a qualitative research with data analysis through triangulation. The purpose of this study is mainly to find out the role of Fintech as one of the financial institutions that support in the field of business capital, especially micro-businesses such as Cibaduyut footwear, one of SME in Bandung City. The results of the study show that the Cibaduyut footwear industry is greatly helped by the existence of this Fintech although in the implementation still faces several obstacles, especially those concerning the knowledge and facilities to support these activities.
PROFITABILITAS DAN STRUKTUR MODAL TERHADAP NILAI PERUSAHAAN DENGAN VARIABEL CORPORATE SOCIAL RESPONSIBILITY SEBAGAI MODERASI
Authors: Mukti Arifin Hamsyah , Winarso Beni Suhendra
Published: June 2021

The purpose of this study was to investigate effect of profitability and capital structure with variable corporate social responsibility as moderation. The sampling technique in this study using purposive sampling method. The type of data this research is quantitative research with data sources used in the study is secondary data. The result of this research that positively affects the profitability of the company’s value, capital structure does not affect the value of the company, CSR moderating influence on the value of the company’s profitability, and CSR does not moderate the affect of capital structure on firm value
ANALISIS PERLAKUAN AKUNTANSI SYARIAH PADA PRODUK PEMBIAYAAN DI BMT BATIK MATARAM YOGYAKARTA
Authors: Sartika Mira Bela , Fithria Annisa
Published: June 2021

This study aims to determine the accounting treatment of murabahah financing transactions, mudharabah financing, and musyarakah financing and to assess the suitability of accounting treatment for murabahah, mudharabah, and musyarakah financing with PSAK 102, PSAK 105, and PSAK 106 seen from the recognition, measurement, presentation, and disclosure. This research is qualitative research with a descriptive approach. The research object used is BMT Batik Mataram. The data collection techniques used are interviews and document review. The data analysis technique used is descriptive qualitative analysis, namely by analyzing the suitability of murabahah, mudharabah, and musyarakah financing transactions at BMT Batik Mataram with PSAK. Based on the study results, it is concluded that the accounting practices for murabahah, mudharabah and musyarakah financing transactions at BMT Batik Mataram are generally in accordance with PSAK 102, PSAK 105, and PSAK 106. However, BMT Batik Mataram is still not fully following PSAK No. 102 since it still imposes fines when there is a delay in instalments.
DETERMINAN KINERJA PENGELOLAAN KEUANGAN DESA
Authors: Nasution Ade Nur Rabbiah , Amalia Dewi
Published: June 2021

This study aims to examine the factors that determinants of financial management performance in village government. Village financial management is all activities that include planning, implementation, administration, reporting and financial accountability of the village. The Village financial management is carried out based on the principles of governance: transparent, accountable and participatory so that good governance can be implemented in the village government administration system. The object of this research is Panggungharjo Village, Sewon District at Bantul Regency. The variables tested were the capacity of village officials, financial reporting compliance, and quality of supervision of the BPD. The method used in this research is the type of quantitative data which is strengthened by interviews and the samples are the village head, treasurer and BPD in Panggungharjo Village. Data collection in this study was conducted through a survey using a questionnaire technique to 39 respondents and structured interviews with the treasurer and BPD. The results of this study are the capacity of village officials, financial reporting compliance, and the quality of BPD supervision that affect the performance of financial management.
From expert to advanced clinical practitioner and beyond
Authors: Mortimore Gerri , Reynolds Julie , Forman Dawn , Brannigan Chris , Mitchell Kathryn
Published: June 2021

This article considers the potential development of advanced clinical practitioners (ACPs) and consultant practitioners, beyond the ‘expert’ status as defined by Pat Benner in 1984. The suggested Derby Model: 7 Levels of Practice Advancement, adapted from Benner's From Novice to Expert, recognises Health Education England's four pillars of advanced practice and how they can be implemented and enhanced within these senior roles, and what that means in a 21st century healthcare system.
Long-term alpine stream monitoring in the Teton Range: Investigating multi-year patterns and thermal physiology
Authors: Tronstad Lusha M. , Giersch J. Joseph , Hotaling Scott , Shah Alisha A. , Zeglin Lydia H. , Bixby Rebecca J. , Woods H. Arthur , Finn Debra S.
Published: June 2021

Alpine streams and the biotic communities they contain are imperiled worldwide due to climate warming and the rapid decline of ice. The loss of glaciers and permanent snowpack may drive local populations to extinction, especially organisms with narrow habitat tolerances. We have been monitoring alpine streams in the Teton Range since 2015 that originate from three hydrological sources: surface glaciers, snowfields, or subterranean ice (e.g., rock glaciers). We call these stream types glacier-fed, snowmelt-fed, and icy seeps, respectively. We hypothesize that icy seeps may persist on the landscape longer than other hydrologic sources and that these features may act as a refuge for cold-adapted organisms such as the stoneflies Zapada glacier and Lednia tetonica. In November 2019, Z. glacier and a sister species of L. tetonica, Lednia tumana, were listed under the U.S. Endangered Species Act. This decision was based in part on work funded by the UW-NPS and highlights the pressing nature of our efforts. In 2019, we collected a 5th year of long-term data to begin investigating multi-year signals in the data. Our second 2019 objective was to further explore how thermal regimes affect tolerance of potentially imperiled insects. Because our annual data collection occurs in late summer with sample processing and analysis extending into the following year, this report will be a broad update on the project as whole, rather than 2019-specific. Through long-term monitoring of streams from different hydrological sources, we are building a dataset that will allow us to understand changes as air temperatures warm and permanent ice is lost in the alpine zone.

 

Featured photo by Nicole Y-C on Unsplash. https://unsplash.com/photos/9XixVlnUCbk
Compliments of Hamilton and Sargent: a story of mystery and tragedy and the closing of the American frontier
Authors: Farrelly Maura Jane
Published: June 2021

Featured photo from figure 4 in report.
Physicochemical Properties of Allulose Mixture According to Replacement Ratio of Sugar
Authors: Kim Hye-Won , Shin Jung-Kue
Published: June 2021

In this study, the change of the physicochemical properties of allulose according to the sugar replacement ratio was studied. The ratio of allulose and sugar was set to 0%, 25%, 50%, 75%, 100%, and changes in moisture content, pH, and Brix were measured. The control (sugar 100%) showed the lowest moisture content of 0.11%, and the moisture content tended to increase as the content of allulose increased. The was no significant difference between the samples according to the replacement of allulose except for 100% sugar and 100% allulose. As a result of measuring the moisture absorption according to the relative humidity, the moisture absorption increased as the allulose content increased, while the moisture absorption increased as the relative humidity increase. The higher the relative humidity and the higher the content of allulose, the longer the moisture absorption period.
Reliability Estimation of 4 × 4 SENs Using UGF Method
Authors: Bisht Vaibhav , Singh S. B.
Published: June 2021

Shuffle Exchange Networks (SENs) are considered as an appropriate interconnection network because they consist of switching elements of small size and possess a straight forward and simple configuration. In this paper, we have proposed a method for analyzing reliability of 4×4 SEN, 4×4 SEN+1 and 4×4 SEN+2. The reliability has been obtained on the basis of three indices, namely, terminal reliability, broadcast reliability and network reliability by using universal generating function (UGF) method. This study also examines effect of adding the additional stages in 4×4 shuffle exchange networks (SENs).
Laser inscribed waveguide optical isolators in iron-doped lithium niobate
Authors: Coco Michael G. , McDaniel Sean A. , Cook Gary
Published: June 2021

There is a growing need for optical isolators that do not require a magnetic field, especially for uses such as on-chip optical devices and cold atom physics. As one approach, we propose using waveguides in photorefractive materials, such as

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, as optical isolator devices due to their unique asymmetric transmission properties that allow low loss transmission in one crystal orientation and attenuation in the flipped orientation. We utilize ultrafast laser inscription to fabricate photorefractive depressed cladding waveguides in

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along the crystal

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axis to demonstrate the operation of

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waveguide optical isolators. We show the ability to write transmission and reflection gratings into these waveguides that provide an isolation ratio of approximately 5000:1 per cm of path length.
GroEL is an immunodominant surface-exposed antigen of Rickettsia typhi
Authors: Rauch Jessica , Barton Jessica , Kwiatkowski Marcel , Wunderlich Malte , Steffen Pascal , Moderzynski Kristin , Papp Stefanie , Höhn Katharina , Schwanke Hella , Witt Susanne , Richardt Ulricke , Mehlhoop Ute , Schlüter Hartmut , Pianka Verena , Fleischer Bernhard , Tappe Dennis , Osterloh Anke
Published: June 2021

Rickettsioses are neglected and emerging potentially fatal febrile diseases that are caused by obligate intracellular bacteria, rickettsiae.Rickettsia(R.)typhiandR.prowazekiiconstitute the typhus group (TG) of rickettsiae and are the causative agents of endemic and epidemic typhus, respectively. We recently generated a monoclonal antibody (BNI52) againstR.typhi. Characterization of BNI52 revealed that it specifically recognizes TG rickettsiae but not the members of the spotted fever group (SFG) rickettsiae. We further show that BNI52 binds to protein fragments of ±30 kDa that are exposed on the bacterial surface and also present in the periplasmic space. These protein fragments apparently derive from the cytosolic GroEL protein ofR.typhiand are also recognized by antibodies in the sera from patients and infected mice. Furthermore, BNI52 opsonizes the bacteria for the uptake by antigen presenting cells (APC), indicating a contribution of GroEL-specific antibodies to protective immunity. Finally, it is interesting that the GroEL protein belongs to 32 proteins that are differentially downregulated byR.typhiafter passage through immunodeficient BALB/c CB17 SCID mice. This could be a hint that the rickettsia GroEL protein may have immunomodulatory properties as shown for the homologous protein from several other bacteria, too. Overall, the results of this study provide evidence that GroEL represents an immunodominant antigen of TG rickettsiae that is recognized by the humoral immune response against these pathogens and that may be interesting as a vaccine candidate. Apart from that, the BNI52 antibody represents a new tool for specific detection of TG rickettsiae in various diagnostic and experimental setups.
The multiple mobilities of civil rights in Jeanine Tesori’s Violet and Caroline, or Change
Authors: Kilner-Johnson Allan
Published: June 2021

This article centres on Jeanine Tesori’s Violet (book and lyrics by Brian Crawley) and Caroline, or Change (book and lyrics by Tony Kushner), both of which are set in the American south during a crucial period in American history running between the assassination of John F. Kennedy on 22 November 1963 and the passing of the Civil Rights Act of 1964. Both works musically capture the imaginative traditions of the American south through gospel, country, Motown, and blues in order to detail the complex negotiations of the titular female protagonists through challenges of isolation, entrapment and liberation in the months following Kennedy's assassination. This article argues that the promise and affordance of mobility within these musicals are rooted in an uncanny spiritual fervour expressed by Violet and Caroline, both of whom have defined a distinctive, and, as will be recognized by each musical’s conclusion, mistaken theology of personal devotion and faith that runs precisely counter to the liberating potentials in the world around them.
The Routledge Companion to the Contemporary Musical, Jessica Sternfeld and Elizabeth L. Wollman (eds) (2020)
Authors: Mann Rebecca
Published: June 2021

Review of: The Routledge Companion to the Contemporary Musical, Jessica Sternfeld and Elizabeth L. Wollman (eds) (2020)

New York: Routledge, 486 pp.,

ISBN 978-1-13868-461-4, eBook, £171.00
Una mirada femenina a los conflictos en el mundo árabe: la invasión de Iraq de 2003 a través de la cobertura de las periodistas de TVE
Authors: Vidal Valiña Carmen Marina
Published: June 2021

Las recientes revoluciones en los países árabes han vuelto a poner de actualidad un área geográfica que en los últimos tiempos ha sido vista por el autodenominado «mundo occidental» con recelo y desconfianza. Pero antes de Túnez, Egipto, Libia o Siria, en el año 2003 asistimos al que es considerado el conflicto armado más mediático de la historia: la Guerra de Iraq. Su preludio, la invasión, fue seguido teóricamente «en directo» por miles de medios de comunicación allí desplazados. En España, frente a la aplastante mayoría de periodistas masculinos, cinco mujeres cubrieron la invasión para la televisión pública, TVE. Saber si lo hicieron de una manera diferenciada y si prestaron atención específica a las mujeres como actores de sus piezas (en suma, si ofrecieron una visión «generizada» del mes y medio de campaña) es el objetivo de este artículo.
Turismo étnico indígena: definición conceptual, potencialidades y desafíos en Brasil
Authors: Souza Nadson Nei Silva de , Irving Marta de Azevedo , Souza Cecília de Mello e , Lima Marcelo Augusto Gurgel de
Published: June 2021

Frente a los impactos socio ambiéntales generados por el turismo contemporáneo, el turismo étnico indígena comienza a entrar en discusión como un camino posible para la conservación de los recursos naturales y de las tradiciones culturales. Así, basándose de una investigación bibliográfica y documental para la construcción de una definición preliminar acerca del tema, este artículo tiene como reto interpretar, críticamente, como se expresa la noción de turismo étnico indígena, en la producción académica nacional y las narrativas de políticas públicas, con enfoque en la Instrução Normativa nº.03/2015, el instrumento legal de referencia acerca del tema en Brasil. Los resultados de esta investigación parecen indicar que aún no existe una perspectiva conceptual consensual sobre el turismo étnico indígena, aunque sean muchas las posibilidades en esta dirección, los retos para su consolidación en el país también son ilimitados. La errónea caracterización cultural y el desarrollo de mecanismos para el fortalecimiento del protagonismo en las poblaciones indígenas en la implementación de proyectos turísticos en sus territorios constituyen ejemplos de los desafíos en este sentido.