bluuebunny/crossref_metadata_2025 huggingface dataset:
Über die Kristallisation der Damasceninsäure als Zwitterion und als Aminocarbonsäure
Authors: Kuhn Richard , Otting Walter , Geider Klaus
Published: June 2007

Damasceninsäure (2‐Methylamino‐3‐methoxy‐benzoesäure) wurde durch Kristallisation aus Äthanol als Zwitterion (1) und aus Wasser als Trihydrat (2) des Zwitterions erhalten. Aus der Schmelze des Trihydrats kristallisierte bei 45–50° das metastabile Dihydrat mit 3 Molekülen der ungeladenen Aminocarbonsäure‐Form (3). Durch Trocknen des Trihydrats (2) entstand die Aminocarbonsäure‐From 4. Die Zuordnung der Strukturen zu den kristallisierten Substanzen erfolgte durch IR‐ und Fluoreszenz‐Spektroskopie, deren Ergebnisse durch die Analyse deuterierter Produkte bestätigt wurden.
Untersuchungen an Diazoverbindungen, III. Neue Synthesemöglichkeiten für Ninhydrin und benzokondensierte Derivate
Authors: Regitz Manfred , Adolph Hans‐Gerd
Published: June 2007

Aus 1.3‐Dioxo‐2‐diazo‐indan (1) und tert.‐Butylhypochlorit in Äthanol entsteht 2.2‐Diäthoxy‐1.3‐dioxo‐indan (2), das sich mit wäßr. Schwefelsäure zu Ninhydrin (3) spalten läßt. Verbindungen mit positivem Halogen (tert.‐Butylhypochlorit, N‐Chlor‐p‐toluolsulfonsäureamid, N‐Brom‐acetamid, N‐Brom‐succinimid) reagieren mit 1 in Carbonsäuren zu 2‐Halogen‐2‐acyloxy‐1.3‐dioxo‐indanen (4a–e). Diese liefern bei der Hydrolyse Ninhydrin (3) und gehen bei der Thermolyse unter Abspaltung von Acylhalogeniden in Trioxo‐indan (5) über. Zur Synthese der benzokondensierten Ninhydrine 12a und b und der Triketone 13a und b wurde der gleiche Weg beschritten. Der Mechanismus der Sauerstoff‐Halogen‐Insertion wird diskutiert.
Alkali‐Phosphorverbindungen und ihr reaktives Verhalten, LIX. Synthese und Reaktionsverhalten der 2‐Amino‐äthylphosphine
Authors: Issleib Kurt , Kümmel Rolf , Oehme Hartmut , Meißner Inge
Published: June 2007

NaPH2 reagiert in flüss. Ammoniak mit 2‐Chlor‐äthylaminen zu 2‐Amino‐äthylphosphinen H2PCH2CH2NRR′(13), die als PH‐acide Substanzen nach erneuter Metallierung und Kupplung mit Alkylhalogeniden zu R′′P(H)CH2CH2NRR (4 – 10) und mit Dihalogenalkanen zu [CH2]n(P(H)CH2CH2NR2)2 (13 – 16) führen. Analog lassen sich ausgehend von C6H5PH2 oder 1 und 3 mit 2‐Chlor‐äthylaminen C6H5P(H)CH2CH2NRR′ und Bis‐ bzw. Tris‐[2‐amino‐äthyl]‐phosphine (17–21) gewinnen. Die Oxydation sek. 2‐Aminoäthylphosphine mit Schwefel liefert [2‐Amino‐äthyl]‐alky‐ bzw. ‐aryldithiophosphinsäuren (22–26) mit Zwitterionenstruktur. Durch gleichzeitige Einwirkung von Diäthylamin und Formaldehyd auf PH‐funktionelle 2‐Amino‐äthylphosphine entstehen [(C2H5)2NCH2]nP‐[CH2CH2NR2]3–n (27, 28).
Leicht abspaltbare Schutzgruppen für die Säureamidfunktion, 3. Derivate des Asparagins und Glutamins mit 2.4‐dimethoxy‐benzyl‐und 2.4.6‐trimethoxy‐benzyl‐geschützten Amidgruppen
Authors: Weygand Friedrich , Steglich Wolfgang , Bjarnason Jonas
Published: June 2007

Die Synthese verschiedener für Peptidsynthesen geeigneter Derivate des Asparagins und Glutamins mit 2.4‐dimethoxy‐benzyl‐ und 2.4.6‐trimethoxy‐benzyl‐geschützten Amidgruppen wird beschrieben. Damit durchgeführte Synthesen einfacher Peptide verlaufen ohne Nebenreaktionen.
Synthesen mit naszierenden Chinonen, V. Synthese des Xylerithrins
Authors: Wanzlick Hans‐Werner , Jahnke Ulrich
Published: June 2007

Eine Totalsynthese des Pilzfarbstoffes Xylerithrin (1) wird beschrieben.
Röntgenographische, NMR‐ und massenspektrometrische Untersuchungen der tert.‐Butylate des Kaliums, Rubidiums und Cäsiums
Authors: Weiss Erwin , Alsdorf Hermann , Kühr Heinrich , Grützmacher Hans‐Friedrich
Published: June 2007

Die tert.‐Butylate (CH3)3COM (M  K, Rb, Cs) kristallisieren nach röntgenographischen Untersuchungen der Kristallpulver kubisch‐primitiv mit den Gitterkonstanten a = 8.475Å (K), 8.610Å (Rb) und 8.902Å (Cs) und vier Formeleinheiten je Elementarzelle. Sie bilden tetramere Struktureinheiten dadurch, daß die Metall‐ und O‐Atome alternierend die Ecken nur wenig verzerrter Würfel besetzen, die von den vier tert.‐Butylgruppen in Richtung der verlängerten Raumdiagonalen umgeben sind. Genaue Atomabstände konnten für die K‐Verbindung ermittelt werden, wogegen im Falle der Rb‐Verbindung nur die Metallatome lokalisiert wurden. Nach 1H‐Breitlinienresonanzuntersuchungen der K‐Verbindung rotieren bei Raumtemperatur die gesamten tert.‐Butylgruppen. Während diese Rotationen bei −20 bis −50° einfrieren, kommt die Bewegung der einzelnen Methylgruppen erst bei tieferen Temperaturen zum Stillstand. Die massenspektrometrische Analyse der K‐Verbindung ergab, daß auch im Dampfzustand ein Tetrameres vorliegt.
Pteridine, XXXVI. Über die Umsetzung von 4‐Chlor‐5‐nitro‐pyrimidinen mit Glucosamin
Authors: Pfleiderer Wolfgang , Bühler Eberhard , Schmidt Dieter
Published: June 2007

Die Umsetzungen von 4‐Chlor‐5‐nitro‐pyrimidinen mit D‐Glucosamin und Folgereaktionen im Hinblick auf Pteridinsynthesen werden beschrieben.
Über Phosphazene, XXII. 31P‐NMR‐Studie zur Methylierung symmetrischer und unsymmetrischer Dithio‐imidodiphosphinsäuren
Authors: Schmidpeter Alfred , Brecht Heinz , Ebeling Joachim
Published: June 2007

Dimethyl‐diphenyl‐dithio‐imidodiphosphinsäure wird bevorzugt am Schwefel des methylsubstituierten Phosphors methyliert. Die Festlegung der Isomeren gelingt durch detaillierten Vergleich der 31P‐Verschiebungen. Die darin zum Ausdruck kommende Konkurrenz um den π‐Beitrag des Phosphazenstickstoffs wird durch die sich überlagernden Effekte von S‐Methylierung und CH3/Ph‐Austausch bestimmt. Der Gang von νasP2N stimmt damit überein. JPCH und JPNPCH haben entgegengesetztes Vorzeichen; JPNPCH ist positiv anzunehmen. JPNPCH und die Abschirmung des koppelnden Phosphors laufen parallel.
Formamidrazon
Authors: Neunhoeffer Hans , Hennig Harald
Published: June 2007

Benzaldehyd‐äthoxymethylenhydrazon (2) reagiert mit Aminen unter Austausch der Äthoxygruppe gegen die Aminogruppe. Die Reaktion von so erhaltenem Benzaldehyd‐aminomethylenhydrazon (3h) mit Phenylhydrazin‐hydrochlorid liefert Formamidrazon‐hydrochlorid (1·HCl).
Über Trimethylazidophosphonium‐, ‐arsonium‐ und ‐stibonium‐hexachloroantimonate (V)
Authors: Schmidt Armin
Published: June 2007

Bei der Umsetzung von Trimethylchlorphosphonium‐, ‐arsonium‐ und ‐stibonium‐hexachloro‐antimonat(V) mit Natriumazid im Molverhältnis 1:1 bilden sich Trimethylazidophosphonium‐ und ‐arsonium‐hexachloroantimonat(V) bzw. Trimethylchlorstibonium‐pentachloro‐azidoantimonat(V). Die Umsetzung mit Natriumazid im Molverhältnis 1 : 2 liefert Trimethylazidophosphonium‐ bzw. ‐arsonium‐pentachloroazidoantimonat(V). Die entsprechende Antimonverbindung wird aus Trimethylstibindiazid und Antimon(V)‐chlorid erhalten. Die IR‐ und 1H‐NMR‐Spektren dieser Verbindungen wurden im Hinblick auf die Bindungsverhältnisse der El‐N3‐Gruppierung diskutiert.
Orthoamide, VIII Über die Umsetzung aktivierter Methylgruppen an substituierten Toluolen und Heterocyclen mit Aminal‐tert.‐butylester zu Enaminen
Authors: Bredereck Hellmut , Simchen Gerhard , Wahl Rudolf
Published: June 2007

Aktivierte Methylgruppen an substituierten Toluolen und Heterocyclen lassen sich mit dem Aminal‐tert.‐butylester 3 zu Enaminen umsetzen; einige dieser Enamine konnten durch saure Hydrolyse in die entsprechend substituierten Aldehyde oder deren Dinitrophenylhydrazone übergeführt werden.
Addition von Triplett‐Inden an Chloräthylene
Authors: Metzner Wolfgang , Hartmann Willy
Published: June 2007

Triplett‐Inden zeigt nur geringe Bereitschaft zur Addition an nicht aktivierte Olefine. Bevorzugt tritt dabei Dimerisation zu 2 ein. Bei Verwendung von Chloräthylenen liegen umgekehrte Verhältnisse vor. Für die Reaktivität von Triplett‐Inden gegenüber den verwendeten Olefinen ergibt sich folgende Reihe: Tetrachloräthylen > 1.1‐Dichlor‐äthylen > Trichloräthylen > trans‐Dichloräthylen > Inden > cis‐Dichloräthylen > Vinylchlorid > Äthylen.
Studien zum Vorgang der Wasserstoffübertragung, 18. Hydrierende Spaltung cyclischer quartärer Ammoniumsalze und einiger Verbindungen mit Brom am Brückenkopf Kernhydrierung von Pyridiniumsalzen und Desoxygenierung einiger N‐Oxide
Authors: Horner Leopold , Röder Heinz
Published: June 2007

In einer Variante der Emmert‐Spaltung werden die cyclischen Ammoniumsalze 1a–c unter Ringöffnung in 2a–c, übergeführt. – Pyridiniumsalze liefern in wäßriger Salzsäure N‐substituierte Piperidinderivate. N‐Oxide werden zu tert. Aminen desoxygeniert; am Brückenkopf gebundenes Brom wird elektrolytisch sehr leicht durch Wasserstoff ersetzt.
Crystal Structures of Incommensurately Modulated Ln(PO3)3 (Ln: Tb—Yb) and Commensurate Gd(PO3)3 and Lu(PO3)3.
Authors: Hoeppe Henning A. , Sedlmaier Stefan J.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Hexachalcogeno—Hypodiphosphates of the Alkali Metals: Synthesis, Crystal Structure and Vibrational Spectra of the Hexathiodiphosphate(IV) Hydrates K4[P2S6]×4H2O, Rb4[P2S6]×6H2O, and Cs4[P2S6]×6H2O.
Authors: Gjikaj Mimoza , Ehrhardt Claus
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Structure Type Among Octahydrated Rare‐Earth Sulfates, β‐Ce2(SO4)3×8H2O, and a New Ce2(SO4)3×4H2O Polymorph.
Authors: Casari Barbara M. , Langer Vratislav
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Trivalent‐Intermediate Valent Cerium Ordering in CeRuSn — A Static Intermediate Valent Cerium Compound with a Superstructure of the CeCoAl Type.
Authors: Riecken Jan F. , Hermes Wilfried , Chevalier Bernard , Hoffmann Rolf‐Dieter , Schappacher Falko M. , Poettgen Rainer
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Magnetic and Electrical Transport Properties of Novel Ln4Ni3Pb4 (Ln: La Ce, Pr) Compounds.
Authors: Kaczorowski D. , Gulay L. D.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Solubility of Nd3+ in Y3Al5O12.
Authors: Klimm D. , Ganschow S. , Pajaczkowska A. , Lipinska L.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phase Equilibria in Cu2Te—In2Te3—{Sb/Bi}2 Te3 Systems and Crystal Structure of CuIn5Te8 Compound.
Authors: Olekseyuk I. D. , Zhbankov O. Ye.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Isothermal Section of the Al—Cr—Si System at 800 °C and the Crystal Structure of τ2 (Cr3Al9Si).
Authors: Chen Hai‐Lin , Weitzer F. , Schuster J. C. , Du Y. , Xu Honghui
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Subsolidus Phase Relationships of the BaO—Ln2O3—CuOz (Ln: Tm and Yb) Systems under Carbonate‐Free Conditions at p(O2) = 100 Pa, and T = 750 °C and 810 °C.
Authors: Wong‐Ng W. , Yang Z. , Cook L. P.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
26‐Ring‐Channel Structure Constructed from Bimetal Phosphite Helical Chains.
Authors: Lai Yu‐Lun , Lii Kwang‐Hwa , Wang Sue‐Lein
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Structure of Europium Aluminium Garnet (EAG).
Authors: Garskaite Editha , Sakirzanovas Simas , Kareiva Aivaras , Glaser Jochen , Meyer H.‐Juergen
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Synthesis of Tertiary Alcohols by the Desymmetrizing Benzoylation of 2‐Substituted Glycerols.
Authors: Jung Byunghyuck , Hong Mi Sook , Kang Sung Ho
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
1,4‐Dichloro‐ and 1,4‐Dibromo‐2‐butenes as Substrates for Cu‐Catalyzed Asymmetric Allylic Substitution.
Authors: Falciola Caroline A. , Alexakis Alexandre
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cyclization Reaction of Cyano‐Substituted Unsaturated Esters Promoted by Conjugate Addition of Organoborons.
Authors: Miura Tomoya , Harumashi Tatsuro , Murakami Mosahiro
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Solvent‐Free Fluorination of Organic Compounds Using N—F Reagents.
Authors: Stavber Gaj , Zupan Marko , Stavber Stojan
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reaction of Tetrahydropyranyl Ethers with Triethylsilyl Trifluoromethanesulfonate‐2,4,6‐Collidine Combination: Speculation on the Intermediate, Efficient Deprotection, and Application to Efficient Ring‐Closing Metathesis as a Tether.
Authors: Fujioka Hiromichi , Okitsu Takashi , Ohnaka Takuya , Sawama Yoshinari , Kubo Ozora , Okamoto Kazuhisa , Kita Yasuyuki
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Efficient One‐Pot Synthesis of 2‐Arylmethyl N‐Substituted Anilines via Yb(OTf)3 Catalyzed Three‐Component Reaction.
Authors: Wang Li‐Min , Zhang Liang , Hu Liang , Tian He
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nickel‐Catalyzed Synthesis of Acrylamides from α‐Olefins and Isocyanates.
Authors: Schleicher Kristin D. , Jamison Timothy F.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rapid Generation of Molecular Complexity: Synthesis of α‐Hydroxyallenes Using Functionalized Grignard Reagents.
Authors: Deutsch Carl , Hoffmann‐Roeder Anja , Domke Axel , Krause Norbert
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regio‐ and Diastereoselective Three‐Component Syntheses of Homoallylic Amines in Aqueous Media Catalyzed by Broensted Acids.
Authors: Deng Dong‐Sheng , Liu Ping , Cai Jiwen
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Mild Conversion of Arylboronic Acids and Their Pinacolyl Boronate Esters into Phenols Using Hydroxylamine.
Authors: Kianmehr Ebrahim , Yahyaee Maryam , Tabatabai Katayoun
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
“Super Silyl” Group for Diastereoselective Sequential Reactions: Access to Complex Chiral Architecture in One Pot.
Authors: Boxer Matthew B. , Yamamoto Hisashi
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Oxidation of Secondary Alcohols Catalyzed by Soluble Chiral Polymeric [N′,N′‐Bis(salicylidene)ethane‐1,2‐diaminato(2—)]manganese(III) ([MnIII(Salen)]) Type Complexes in a Biphasic System.
Authors: Sun Wei , Wu Xiaomei , Xia Chungu
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Asymmetric Synthesis of Allylic Aryl Ethers.
Authors: Kirsch Stefan F. , Overman Larry E. , White Nicole S.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rh‐Catalyzed Highly Enantioselective Synthesis of 3‐Arylbutanoic Acids.
Authors: Sun Xianfeng , Zhou Le , Wang Chun‐Jiang , Zhang Xumu
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dynamic Kinetic Resolution of 2‐Oxo‐3‐aryl‐succinates by Organocatalyzed Aldolization.
Authors: Wang Yajun , Shen Zongxuan , Li Bin , Zhang Yong , Zhang Yawen
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel One‐Pot Synthesis of Unsymmetrical Acyclic Imides.
Authors: Habibi Zohreh , Salehi Peyman , Zolfigol Mohammad Ali , Yousefi Maryam
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Metal‐Free, Enantioselective Strecker Reactions Catalyzed by Chiral BINOL and TADDOL Catalysts.
Authors: Rueping Magnus , Sugiono Erli , Moreth Stefan A.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Trichlorophenol (TCP) Sulfonate Esters: A Selective Alternative to Pentafluorophenol (PFP) Esters and Sulfonyl Chlorides for the Preparation of Sulfonamides.
Authors: Wilden Jonathan D. , Geldeard Lynsey , Lee Chieh C. , Judd Duncan B. , Caddick Stephen
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Diarylmethanols by Catalyzed Asymmetric Aryl Transfer Reactions onto Aldehydes Using Boronic Acids as Aryl Source.
Authors: Schmidt Frank , Rudolph Jens , Bolm Carsten
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereospecific Synthesis of Bisdihydroxylated Dicyclopentadiene.
Authors: Salamci Emine , Sahin Ertan
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
4‐Fluorocyclohexa‐2,5‐dienones as New Acceptors for the Hauser Annulation.
Authors: Pahari Pallab , Senapati Bidyut , Mal Dipakranjan
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Unusual Conversion of 1‐Alkyl‐2‐(bromomethyl)aziridines into 1‐Alkyl‐2‐(N‐alkyl‐N‐ethylaminomethyl)aziridines Using Methyllithium.
Authors: D'hooghe Matthias , De Kimpe Norbert
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Diversity‐Oriented Preparation of Enantiopure Spirocyclic 2‐Azetidinones from α‐Oxo‐β‐lactams Through Barbier‐Type Reactions Followed by Metal‐Catalyzed Cyclizations.
Authors: Alcaide Benito , Almendros Pedro , Martinez del Campo Teresa , Rodriguez‐Acebes Raquel
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Catalyzed Synthesis of Lipophilic Benzo[b]furans from Cardanol.
Authors: Bernini Roberta , Cacchi Sandro , De Salve Ilse , Fabrizi Giancarlo
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave Induced Synthesis of Diphenylthiophenes from Elemental Sulfur and Styrene.
Authors: Yas'ko S. V. , Korchevin N. A. , Gusarova N. K. , Kazantseva T. I. , Chernysheva N. A. , Klyba L. V. , Trofimov B. A.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
3‐[2‐((2S)‐2‐Cyano‐pyrrolidin‐1‐yl)‐2‐oxo‐ethylamino] ‐3‐methylbutyramide Analogues as Selective DPP‐IV Inhibitors for the Treatment of Type‐II Diabetes.
Authors: Jiaang Weir‐Torn , et al. et al.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Difluoromethylenation Using Me3SiCF2SPh: Synthesis of Chiral 2,4‐Disubstituted 3,3‐Difluoropyrrolidines.
Authors: Li Ya , Hu Jinbo
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Method for the Synthesis of Chiral Pyrrolidine Derivatives via Ring‐Closing Enyne Metathesis Reaction.
Authors: Yang Qian , Alper Howard , Xiao Wen‐Jing
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dioxomolybdenum(VI)‐Catalyzed Reductive Cyclization of Nitroaromatics. Synthesis of Carbazoles and Indoles.
Authors: Sanz Roberto , Escribano Jaime , Pedrosa Maria R. , Aguado Rafael , Arnaiz Francisco J.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Synthesis of Benzhydroximoyl Chloride and Nitrile Oxides under Solvent‐Free Conditions.
Authors: Bigdeli Mohammad A. , Mahdavinia Gholam Hossein , Jafari Saeed
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Click Chemistry in CuI‐Zeolites: The Huisgen [3 + 2]‐Cycloaddition.
Authors: Chassaing Stefan , Kumarraja Mayilvasagam , Sido Abdelkarim Sani Souna , Pale Patrick , Sommer Jean
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Weak Base Dispiro‐1,2,4‐trioxolanes: Potent Antimalarial Ozonides.
Authors: Vennerstrom Jonathan L. , et al. et al.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Catalyzed Buchwald—Hartwig Coupling of Deactivated Aminothiophenes with Substituted Halopyridines.
Authors: Begouin Agathe , Hesse Stephanie , Queiroz Maria‐Joao R. P. , Kirsch Gilbert
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
RuCl2(dmso)4 Catalyzes the Solvent‐Free Indirect Friedlaender Synthesis of Polysubstituted Quinolines from Alcohols.
Authors: Martinez Ricardo , Ramon Diego J. , Yus Miguel
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 3‐(1H‐Benzimidazol‐2‐yl)‐5‐isoquinolin‐4‐ylpyrazolo[1,2‐b]pyridine, a Potent Cyclin Dependent Kinase 1 (CDK1) Inhibitor.
Authors: Huang Shenlin , Lin Ronghui , Yu Yang , Lu Yanhua , Connolly Peter J. , Chiu George , Li Shengjian , Emanuel Stuart L. , Middleton Steven A.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N‐(3‐Cyano‐4,5,6,7‐tetrahydro‐1‐benzothien‐2‐yl)amides as Potent Selective, Inhibitors of JNK2 and JNK3.
Authors: Christopher John A. , et al. et al.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selective Palladium‐Catalyzed Amination of the Heterocyclic Core of Variolins.
Authors: Baeza Alejandro , Burgos Carolina , Alvarez‐Builla Julio , Vaquero Juan J.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Superacid‐Catalyzed Arylation and Rearrangement in 2‐Hydroxy‐2,2′‐biindan‐1,1′,3,3′‐tetrone and Facile Synthesis of 4‐Substituted Phthalazinones.
Authors: Das Suven , Froehlich Roland , Pramanik Animesh
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Characterization of New Quinazolines as Potential Antimicrobial Agents.
Authors: Desai N. C. , Shihora P. N. , Moradia D. L.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Amino Acid Based Enantiomerically Pure 3‐Substituted 1,4‐Benzodiazepin‐2‐ones: A New Class of Antiischemic Agents.
Authors: Mishra Jitendra Kumar , Garg Puja , Dohare Preeti , Kumar Ashutosh , Siddiqi Mohammad Imran , Ray Madhur , Panda Gautam
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Preparation of Medium Ring Oxygen Heterocycles.
Authors: Nishiguchi Atsuko , Ikemoto Tomomi , Ito Tatsuya , Miura Shotaro , Tomimatsu Kiminori
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxacalixarenes and Oxacyclophanes Containing 1,8‐Naphthyridines: A New Class of Molecular Tweezers with Concave‐Surface Functionality.
Authors: Katz Jeffrey L. , Geller Bram J. , Foster Peter D.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Isochalcogenazole Rings by Treating β‐(N,N‐Dimethylcarbamoylchalcogenenyl)alkenyl Ketones with Hydroxylamine‐O‐sulfonic Acid.
Authors: Shimada Kazuaki , et al. et al.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Discovery of Novel Phosphorus‐Containing Steroids as Selective Glucocorticoid Receptor Antagonist.
Authors: Jiang Weiqin , et al. et al.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Synthesis of N‐Cbz‐L‐BMAA and Derivatives from N‐Cbz‐L‐serine.
Authors: Moura Sidnei , Pinto Ernani
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Diastereoselective Synthesis of Glycosylated Prolines as α‐Glucosidase Inhibitors and Organocatalyst in Asymmetric Aldol Reaction.
Authors: Pandey Jyoti , Dwivedi Namrata , Singh Nimisha , Srivastava A. K. , Tamarkar A. , Tripathi R. P.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intramolecular Nitrile Oxide—Alkene Cycloaddition of Sugar Derivatives with Unmasked Hydroxyl Group(s).
Authors: Shing Tony K. M. , Wong Wai F. , Cheng Hau M. , Kwok Wun S. , So King H.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Synthesis of 5‐Aryltriazole Acyclonucleosides via Suzuki Coupling in Aqueous Solution.
Authors: Zhu Ruizhi , Qu Fanqi , Quelever Gilles , Peng Ling
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Concise Synthesis of Maleic Anhydride and Maleimide Natural Products Found in Antrodia camphorata.
Authors: Stewart Scott G. , Polomska Marta E. , Lim Rou Wei
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of Papulacandin D.
Authors: Denmark Scott E. , Regens Christopher S. , Kobayashi Tetsuya
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Verticillin G, a New Antibacterial Compound from Bionectra byssicola
Authors: Zheng Chang‐Ji , Park Soo‐Hee , Koshino Hiroyuki , Kim Young‐Ho , Kim Won‐Gon
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Practical Total Synthesis of (+)‐Antimycin A9.
Authors: Nishii Takeshi , Inai Makoto , Kaku Hiroto , Horikawa Hitsuyo , Tsunoda Tetsuto
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of the C11‐C21 Fragments of Epothilones A and B Using Ring‐Closing Metathesis.
Authors: Hong Yong Deog , Lee Hyo Won , Lee Ihl Young Choi , Jung Jae‐Kyung
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Electron Paramagnetic Resonance: A Powerful Tool for Monitoring Working Catalysts
Authors: Brueckner Angelika
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Moessbauer Spectroscopy in Heterogeneous Catalysis
Authors: Millet Jean‐Marc M.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Use of Tetrazolium Salts in Inorganic Analysis
Authors: Gavazov K. B. , Dimitrov A. N. , Lekova V. D.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gold Nanoparticles: Preparation, Functionalization and Applications in Biochemistry and Immunochemistry
Authors: Dykman L. A. , Bogatyrev V. A.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Evolution of Organo‐Cyanometallate Cages: Supramolecular Architectures and New Cs+‐Specific Receptors
Authors: Boyer Julie L. , Kuhlman Matthew L. , Rauchfuss Thomas B.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bioinorganic Chemistry of Bismuth and Antimony: Target Sites of Metallodrugs
Authors: Ge Ruiguang , Sun Hongzhe
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Advances in Organotrifluoroborates Chemistry
Authors: Stefani Helio A. , Cella Rodrigo , Vieira Adriano S.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chalcogen‐Rich Compounds as Electron Donors
Authors: Westgate Thomas D. , Skabara Peter J.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Formation and Recognition Properties of Dynamic Combinatorial Libraries
Authors: Hamilton Andrew D. , Tagore Debarati M. , Sprinz K. Ingrid
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molecular Containers in Action
Authors: Rudkevich Dmitry M.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Heterogeneous Catalysis
Authors: Osawa Tsutomu
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enzymes in Organic Synthesis: Aldolase‐Mediated Synthesis of Iminocyclitols and Novel Heterocycles
Authors: Whalem Lisa J. , Wong Chi‐Huey
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Use of Cyclic Bifunctional Protecting Groups in Oligosaccharide Synthesis
Authors: Litjens Remy E. J. N. , Van den Bos Leendert J. , Codee Jeroen D. C. , Overkleeft Herman S. , Van der Marel Gijsbert A.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Boron — A Key Element in Radical Reactions
Authors: Renaud Philippe , Beauseigneur Alice , Brecht‐Forster Andrea , Becattini Barbara , Darmency Vincent , Kandhasamy Sarkunam , Montermini Florian , Ollivier Cyril , Panchaud Philippe , Pozzi Davide , et al. et al.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Functional Phosphorus‐Based π‐Conjugated Systems: Structural Diversity without Multistep Synthesis
Authors: Hissler Muriel , Lescop Christophe , Reau Regis
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Envirocats: Ecofriendly Catalysts
Authors: Mahajan S. S. , Ghatpande S. S.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Epoxidation of Pentadienols
Authors: Brueckner Reinhard
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Advances and Applications in 1,2,4,5‐Tetrazine Chemistry
Authors: Saracoglu Nurullah
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Histone Modification Enzymes Induced During Chemical Hepatocarcinogenesis
Authors: Osada Shigehiro
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Progress of the Study of Rho‐Kinase and Future Perspective of the Inhibitor
Authors: Tawara Shunsuke , Shimokawa Hiroaki
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Charge Transport in Organic Semiconductors
Authors: Coropceanu Veaceslav , Cornil Jerome , da Silva Filho Demetrio A. , Olivier Yoann , Silbey Robert , Bredas Jean‐Luc
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Non‐Linear Effects in Asymmetric Catalysis
Authors: Kagan Henri B.
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Assessment of Environmental Fate and Exposure Variability of Organic Contaminants
Authors: Suzuki Noriyuki
Published: June 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Partial resolution of racemic trans‐4‐[5‐(4‐alkoxyphenyl)‐2,5‐dimethylpyrrolidine‐1‐oxyl‐2‐yl]benzoic acids by the diastereomer method with (R)‐ or (S)‐1‐phenylethylamine
Authors: Uchida Yoshiaki , Uematsu Toshifumi , Nakayama Yoichi , Takahashi Hiroki , Tsue Hirohito , Tanaka Koichi , Tamura Rui
Published: June 2007

The partial resolution is described of a series of racemic trans‐4‐[5‐(4‐alkoxyphenyl)‐2,5‐dimethylpyrrolidine‐1‐oxyl‐2‐yl]benzoic acids (1), which are the key intermediates for the synthesis of chiral organic radical liquid crystalline compounds and are crystallized to give racemic compounds. Racemic acid 1 [(±)‐1] with a long alkyl chain (C7 to C13) could be resolved by the conventional diastereomeric salt formation using (R)‐ or (S)‐1‐phenylethylamine (2) as the resolving agent, whereas resolution of (±)‐1 with a short alkyl chain (C4 to C6) was unsuccessful. Use of six equiv of (R)‐ or (S)‐2 for the initial diastereomeric salt formation of (±)‐1 with a C7‐C13 alkyl chain, followed by recrystallization of the resulting salts once or twice, gave 2S,5S‐ or 2R,5R‐enriched 1, respectively, in an ee range of 75–92% and with an overall recovery of 11–27%, based on the original quantity of (±)‐1. Chirality, 2008. © 2007 Wiley‐Liss, Inc.
Structures and inclusion properties of racemic and enantiopure dimethyl and diphenyl 9,9′‐bianthryl‐2,2′‐dicarboxylates
Authors: Toyota Shinji , Shimasaki Toshiaki , Hirano Shinya , Kuga Makoto , Toda Fumio
Published: June 2007

The authors prepared the dimethyl and diphenyl esters of 9,9′‐bianthryl‐2,2′‐dicarboxylic acid in racemic and enantiopure (M) forms. The enantiopure dimethyl ester forms inclusion compounds with various organic compounds such as benzene, methanol, phenol, and aniline whereas the racemic form does this only with benzene. No guest molecules are included by the racemic and enantiopure diphenyl esters. These effects of substituents and homochirality on the inclusion properties are discussed on the basis of X‐ray structures of some inclusion and guest‐free compounds. Chirality, 2008. © 2007 Wiley‐Liss, Inc.
Continuous 12‐lead st‐segment monitoring improves identification of low‐risk patients with chest pain and a worse in‐hospital outcome
Authors: Pelliccia Francesco , Cianfrocca Cinzia , Marazzi Giuseppe , Pagliei Mario , Mariani Marcello , Rosano Giuseppe M. C.
Published: June 2007

Background: Various strategies have been proposed to improve diagnosis and triage of patients with chest pain at low risk, but uncertainty still exists on the optimal combination of diagnostic tools that should be used in this subset of patients.

Hypothesis: The aim of this study was to evaluate the incremental benefit of continuous 12‐lead ST‐segment monitoring over that provided by conventional diagnostic tools in patients with chest pain.

Methods: Of 232 consecutive patients referred because of chest pain, 52 were classified as low‐risk according to the Agency for Health Care Policy and Research unstable angina guidelines and observed for 12 h with serial cardiac enzymes and electrocardiograms (ECG) (every 3 h). All patients also underwent both echocardiography at entry and continuous 12‐lead ST‐segment monitoring during the observation period.

Results: During a mean hospital stay of 3.7 days (range 1‐14 days), a benign outcome was observed in 37 patients (71%), whereas 15 patients (29%) had major cardiac events or recurrence of chest pain of ischemic origin. Addition of ST‐segment monitoring findings to baseline clinical data as well as to serial enzymes and ECG features added significant incremental prognostic value (p < 0.001). Multivariate analysis showed reproduction of pain by chest pressure (p < 0.05) and presence of ST‐segment changes (≥ 0.1 mV) during 12‐lead ST‐segment monitoring (p < 0.001) as independent predictors of a benign or unfavorable outcome.

Conclusions: In low‐risk patients with chest pain, continuous 12‐lead ST‐segment monitoring provides significant incremental diagnostic and prognostic information to currently used clinical, enzymatic, and ECG data, and is helpful in identifying the subset of patients with a worse in‐hospital outcome.
Coronary intervention in the diabetic patient: Improved outcome following stent implantation compared with balloon angioplasty
Authors: Savage Michael P. , Fischman David L. , Schatz Richard A. , Leon Martin B. , Baim Donald S. , Brinker Jeffrey , Hirshfeld John , Goldberg Sheldon
Published: June 2007

Background: Diabetic patients undergoing coronary interventional procedures are at increased risk of restenosis and adverse clinical events. The relative impact of stents compared with balloon angioplasty on the outcome of percutaneous intervention in diabetics remains controversial.

Hypothesis: The goal of this study was to determine whether stent placement was superior to balloon angioplasty in reducing restenosis of diabetic patients undergoing coronary intervention.

Methods: The STRESS Trial was a prospective randomized comparison of stent placement and balloon angioplasty in the treatment of new native coronary lesions. Of 594 randomized patients, 92 (16%) were diabetic. In this substudy analysis of the STRESS Trial, the outcomes after stenting and balloon angioplasty in diabetic patients were compared. The primary endpoint was restenosis as determined by angiography at 6 months. Clinical outcomes at 1 year were assessed.

Results: Procedural success was achieved in 82% of diabetic patients assigned to angioplasty and in 100% assigned to stenting (p <0.01). Compared with angioplasty, stenting resulted in a larger postprocedural lumen diameter (2.34 ± 0.44 vs. 1.87 ± 0.52 mm, p < 0.001) and greater acute luminal gain (1.61 ± 0.47 vs. 1.06 ± 0.46 mm, p < 0.001). At 6 months, stenting conferred a larger lumen (1.69 ± 0.57 vs.1.38 ± 0.60 mm, p = 0.03) and greater net luminal gain (0.97 ± 0.55 vs. 0.52 ± 0.52 mm, p < 0.001). Restenosis occurred in 60% of the angioplasty group and in 24% of the stent group (p < 0.01). This was accompanied by a lower need for repeat target vessel revascularization after stenting (31 vs. 13%, p < 0.03).

Conclusions: Compared with balloon angioplasty, stent placement in diabetic patients with focal de novo lesions resulted in superior procedural results, reduced restenosis, and improved clinical outcome with fewer repeat revascularization procedures.