bluuebunny/crossref_metadata_2025 huggingface dataset:
CO-CREATE FINANCIAL PLANNING SERVICES FOR AN AGING POPULATION: DESIGNERS' PERSPECTIVES
Authors: Lee Sheng-Hung , Coughlin Joseph F. , Yang Maria , de Weck Olivier L. , Lee Chaiwoo , Klopfer Eric , Ochsendorf John
Published: June 2023

The purpose of the study is to understand the design considerations for creating a provocative financial planning toolkit with services to help facilitate more constructive and meaningful conversations to build trust and empathy between financial advisors and senior people. We conducted four rounds of 60-minute co-creation workshops with eight invited participants from various design disciplines to work in pairs to generate four preliminary concepts suggesting design considerations. We used ATLAS.ti to do qualitative research analysis under an NCT (notice, collecting, thinking) model to identify 22 codes synthesized from verbal and behavioral data. The study concluded with three design principles: 1) the concept of financial planning is about people's expectation management, 2) a financial planning toolkit is designed under service systems, and 3) the tailor-made and modular design features can give financial advisors more flexibility to engage with senior people and enable them to share more about their life stories and needs to recommend financial planning packages precisely according to personal preference, health conditions, and financial status.
DIDYMUS’ COMMENTARY ON PINDAR'S PAEANS
Authors: Prodi Enrico Emanuele
Published: June 2023

This article examines the citation of Didymus’ ‘first’ commentary on Pindar's Paeans in Ammon. Diff. 231 Nickau. It argues that the commentary on the Paeans was the first volume in Didymus’ commentary to all of Pindar.
Logistics of care: Trust-reform and self-managing teams in municipal home care services
Authors: Hansen Helle Cathrine , Neumann Cecilie Basberg
Published: June 2023

The central idea in trust-reform is to improve service delivery by granting professional autonomy and acknowledging the experiential knowledge of professionals. In this article, we study trust-reform bottom-up from the perspective of frontline care workers. Our aim is to discuss the challenges for care work and care workers who have been organised in self-managing teams, paying particular attention to the organising of the daily work in the teams. This study draws on data from four months of fieldwork in Norwegian municipal home care services for older people. The article sheds light on some problematic aspects in trust-reform regarding the relationship between frontline workers’ autonomy and responsibility on the one hand and the lack of authority and managerial support on the other hand. The study demonstrates that trust-reforms within public service delivery can be experienced as delegation of logistical tasks and enhanced responsibility instead of delegation of the authority that is necessary for professional care work to be performed. As such, trust-reforms risk obstructing rather than advancing their declared intentions of strengthening professional agency in care work, and rather than distributing management tasks, trust-reforms need to strengthen the management function in order to succeed.
Kaposiform hemangioendothelioma of the heart: a case report and literature review
Authors: Fan Di , Cui Yun , Chen Jing , He Xinjian
Published: June 2023

Kaposiform hemangioendothelioma is a rare tumour of vascular origin that rarely occurs in the heart. We provided a rare case of a 26-day-old infant with tachypnoea. Echocardiography showed a solid tumour in the pericardial cavity and a large amount of pericardial effusion. The solid tumour was confirmed by surgery, and the pathology was kaposiform hemangioendothelioma. We analysed this case and reviewed the related literature to explore the clinical features and echocardiographic manifestations to improve the understanding, diagnosis, and treatment of this disease for clinicians and sonographers.
The Effect of Counterstereotypic Gender Strategies on Candidate Evaluations in American Elections
Authors: Wang Ding , Merolla Jennifer L. , Manganiello Arielle
Published: June 2023

Women who ran for office in 2018 used a variety of strategies on the campaign trail, with some highlighting more masculine traits and others more feminine traits, but the latter was more common than in prior years. We ask how effective these strategies are for trait evaluations, perceptions of leadership and competence, likeability, and vote choice and how this effect varies based on respondent’s views about the role of women in society. To explore these relationships, we use data from a two-wave panel conducted in the winter of 2019. Results from our experiment show that female candidates who highlight more masculine traits are perceived as more agentic, less communal, and more competent, and, importantly, they do not appear to suffer from a backlash effect. Those higher in sexism also evaluate women who display these qualities as more competent, though as less warm and likable.
Urinary 2- to 16α-hydroxyestrone ratio did not change with cruciferous vegetable intake in premenopausal women
Authors: Davis Stephanie J. , Arscott Sara A. , Goltz Shellen , Muir Cassidy , Binkley Neil , Tanumihardjo Sherry A.
Published: June 2023

Abstract: The mass ratio of urinary 2-hydroxyestrone to 16-α-hydroxyestrone (2:16) is hypothesized as a biomarker of breast cancer risk in premenopausal women, with higher ratios being theoretically protective. Cruciferous vegetable intake has been associated with higher urinary 2:16 in some studies. We investigated whether a whole-food supplement made from dried Brussels sprouts and kale would increase urinary 2:16 in comparison with placebo or cruciferous vegetables in women. This randomized, parallel arm, placebo-controlled, partly blinded study included 78 healthy premenopausal women (38–50 y) with screening urinary 2:16 ≤3.0. Subjects received either six capsules containing 550 mg dried Brussels sprouts and kale per capsule, 40 g daily alternating broccoli or Brussels sprouts, or placebo for eight weeks. Urinary 2:16 and creatinine were measured at baseline, four, and eight weeks. Intent-to-treat repeated measures-ANOVA with multiple imputation ( n=100) for missing values identified no treatment effect ( P=0.9) or treatment-by-time interaction ( P=0.6); however, a significant time effect was noted ( P=0.02). Per-protocol analyses including complete cases found no treatment effect ( P=1) or treatment-by-time interaction ( P=0.6); however, the significant time effect remained ( P=0.03). Restricting analysis to subjects with >80% compliance maintained the time effect ( P=0.02). Using Pearson correlations, android-pattern and android:gynoid fat were predictive of change ( P≤0.05). In conclusion, neither cruciferous supplements nor an added vegetable serving altered urinary 2:16 in premenopausal women with eight weeks treatment. This ratio did vary with time, which is important for designing future trials.
Comparing the Effect of Anthropogenically Amplified Halogen Natural Emissions on Tropospheric Ozone Chemistry Between Pre‐Industrial and Present‐Day
Authors: Barrera Javier A. , Kinnison Douglas E. , Fernandez Rafael P. , Lamarque Jean‐François , Cuevas Carlos A. , Tilmes Simone , Saiz‐Lopez Alfonso
Published: June 2023

Reactive halogens (X + XO, X = I, Br or Cl) catalytically destroy a fraction of tropospheric ozone under present‐day (PD) conditions, however, their distribution and potential impact on tropospheric ozone under pre‐industrial (PI) conditions remain largely unexplored. This study uses the Community Atmosphere Model with Chemistry (CAM‐Chem) to investigate the effect of anthropogenically amplified natural emissions of halogenated species and their subsequent chemistry on tropospheric ozone under PI and PD atmospheric conditions. Model results show that the global tropospheric ozone depletion due to natural halogens is slightly more sensitive in PI than PD, with percentage changes in tropospheric ozone burden (TOB) of −14.1 ± 0.6% for PI and −12.9 ± 0.6% for PD. Individually, the role of iodine and chlorine in ozone depletion is equivalent in both periods (ΔTOBI: ∼−7% and ΔTOBCl: ∼−2.5%), while bromine plays a larger role in PI (ΔTOBBr: −5.5 ± 0.6%) versus PD (ΔTOBBr: −4.3 ± 0.7%). The increase in anthropogenic ozone precursor emissions from PI to PD has amplified the natural emission of inorganic halogens and led to a shift in the partitioning of inorganic halogens from reactive to reservoir species. Consequently, halogen‐driven ozone depletion from the surface to the free troposphere is larger in PI than PD. In contrast, in the upper troposphere, the ozone depletion is larger in PD influenced mainly by stratospheric intrusion of reactive halogens from long‐lived species. This study highlights the importance of including a complete chemical coupling of natural halogens and atmospheric pollutants in chemistry‐climate models to adequately assess their effects on tropospheric ozone in a changing climate.
Estimating Paleointensities From Chemical Remanent Magnetizations of Magnetite Using Non‐Heating Methods
Authors: Maurel C. , Gattacceca J.
Published: June 2023

Many meteorites experienced aqueous alteration on their parent body. During this process, magnetite usually forms and acquires a chemical remanent magnetization (CRM) if growing in the presence of a magnetic field. The epoch of aqueous alteration on planetesimals encompasses the lifetime of the solar nebula. Therefore, magnetite‐bearing meteorites are potential sources of invaluable data regarding the intensity of the solar nebula magnetic field and its influence on planetary accretion. The major limitation encountered in meteorite paleomagnetic studies is the lack of an empirical law relating a CRM characterized using non‐heating methods and the magnetizing field intensity. This issue is usually bypassed using the empirical law for non‐heating methods calibrated for thermoremanent magnetizations (TRM), resulting in poorly constrained paleointensities. Here, we determine such an empirical law through a series of CRM acquisition experiments. Magnetite is grown in weakly magnetic sedimentary rocks and synthetic samples in a magnetic field while heated at 350°C for 5 hr in an argon atmosphere. All samples exhibit a high‐coercivity magnetization parallel and proportional to the field applied, identified as a CRM carried by magnetite. We determine the CRM empirical law by retrieving the applied field intensity using non‐heating methods. The empirical coefficients differ from the TRM ones by a factor of 1.9–3.2 depending on the method. We use these coefficients to revisit the paleointensities published for the CM chondrite Murchison and the C2 ungrouped Tagish Lake. This empirical law opens the door to the study of numerous magnetite‐bearing meteorites potentially carrying a CRM.
The role of cellular and molecular neuroimmune crosstalk in gut immunity
Authors: Yang Daping , Almanzar Nicole , Chiu Isaac M.
Published: June 2023

The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune system. These two systems critically coordinate the sensations of and adaptations to dietary, microbial, and damaging stimuli from the external and internal microenvironment during tissue homeostasis and inflammation. The brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic neurons. Neurons regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain axis. This neuroimmune crosstalk is critical for gut homeostatic maintenance and disease resolution. In this review, we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal immunity. We will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and inflammation. We also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.
Preimplantation genetic testing for Neurofibromatosis type 1: more than 20 years of clinical experience
Authors: Vernimmen Vivian , Paulussen Aimée D. C. , Dreesen Jos C. F. M. , van Golde Ron J. , Zamani Esteki Masoud , Coonen Edith , van Buul-van Zwet Marianne L. , Homminga Irene , Derijck Alwin A. H. A. , Brandts Lloyd , Stumpel Constance T. R. M. , de Die-Smulders Christine E. M.
Published: June 2023

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder that affects the skin and the nervous system. The condition is completely penetrant with extreme clinical variability, resulting in unpredictable manifestations in affected offspring, complicating reproductive decision-making. One of the reproductive options to prevent the birth of affected offspring is preimplantation genetic testing (PGT). We performed a retrospective review of the medical files of all couples (n = 140) referred to the Dutch PGT expert center with the indication NF1 between January 1997 and January 2020. Of the couples considering PGT, 43 opted out and 15 were not eligible because of failure to identify the underlying genetic defect or unmet criteria for in vitro fertilization (IVF) treatment. The remaining 82 couples proceeded with PGT. Fertility assessment prior to IVF treatment showed a higher percentage of male infertility in males affected with NF1 compared to the partners of affected females. Cardiac evaluations in women with NF1 showed no contraindications for IVF treatment or pregnancy. For 67 couples, 143 PGT cycles were performed. Complications of IVF treatment were not more prevalent in affected females compared to partners of affected males. The transfer of 174 (out of 295) unaffected embryos led to 42 ongoing pregnancies with a pregnancy rate of 24.1% per embryo transfer. There are no documented cases of misdiagnosis following PGT in this cohort. With these results, we aim to provide an overview of PGT for NF1 with regard to success rate and safety, to optimize reproductive counseling and PGT treatment for NF1 patients.
Genetic characterization of non-5q proximal spinal muscular atrophy in a French cohort: the place of whole exome sequencing
Authors: Theuriet Julian , Fernandez-Eulate Gorka , Latour Philippe , Stojkovic Tanya , Masingue Marion , Vidoni Léo , Bernard Emilien , Jacquier Arnaud , Schaeffer Laurent , Salort-Campana Emmanuelle , Chanson Jean-Baptiste , Pakleza Aleksandra Nadaj , Kaminsky Anne-Laure , Svahn Juliette , Manel Véronique , Bouhour Françoise , Pegat Antoine
Published: June 2023

Proximal spinal muscular atrophy (SMA) is defined by a degeneration of the anterior horn cells resulting in muscle weakness predominantly in the proximal lower limbs. While most patients carry a biallelic deletion in the SMN1 gene (localized in chromosome 5q), little is known regarding patients without SMN1-mutation, and a genetic diagnosis is not always possible. Here, we report a cohort of 24 French patients with non-5q proximal SMA from five neuromuscular centers who all, except two, had next-generation sequencing (NGS) gene panel, followed by whole exome sequencing (WES) if gene panel showed a negative result. The two remaining patients benefited directly from WES or whole genome sequencing (WGS). A total of ten patients with causative variants were identified, nine of whom were index cases (9/23 families = 39%). Eight variants were identified by gene panel: five variants in DYNC1H1, and three in BICD2. Compound heterozygous causative variants in ASAH1 were identified directly by WES, and one variant in DYNC1H1 was identified directly by WGS. No causative variant was found using WES in patients with a previous panel with negative results (14 cases). We thus recommend using primarily NGS panels in patients with non-5q-SMA and using WES, especially when several members of the same family are affected and/or when trio analyses are possible, or WGS as second-line testing if available.
Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations
Authors: Ahmad Katya , Javed Abid , Lanphere Conor , Coveney Peter V. , Orlova Elena V. , Howorka Stefan
Published: June 2023

DNA can be folded into rationally designed, unique, and functional materials. To fully realise the potential of these DNA materials, a fundamental understanding of their structure and dynamics is necessary, both in simple solvents as well as more complex and diverse anisotropic environments. Here we analyse an archetypal six-duplex DNA nanoarchitecture with single-particle cryo-electron microscopy and molecular dynamics simulations in solvents of tunable ionic strength and within the anisotropic environment of biological membranes. Outside lipid bilayers, the six-duplex bundle lacks the designed symmetrical barrel-type architecture. Rather, duplexes are arranged in non-hexagonal fashion and are disorted to form a wider, less elongated structure. Insertion into lipid membranes, however, restores the anticipated barrel shape due to lateral duplex compression by the bilayer. The salt concentration has a drastic impact on the stability of the inserted barrel-shaped DNA nanopore given the tunable electrostatic repulsion between the negatively charged duplexes. By synergistically combining experiments and simulations, we increase fundamental understanding into the environment-dependent structural dynamics of a widely used nanoarchitecture. This insight will pave the way for future engineering and biosensing applications.
Asynchronous locking in metamaterials of fluids of light and sound
Authors: Chafatinos D. L. , Kuznetsov A. S. , Reynoso A. A. , Usaj G. , Sesin P. , Papuccio I. , Bruchhausen A. E. , Biermann K. , Santos P. V. , Fainstein A.
Published: June 2023

Lattices of exciton-polariton condensates represent an attractive platform for the study and implementation of non-Hermitian bosonic quantum systems with strong non-linear interactions. The possibility to actuate on them with a time dependent drive could provide for example the means to induce resonant inter-level transitions, or to perform Floquet engineering or Landau-Zener-Stückelberg state preparation. Here, we introduce polaromechanical metamaterials, two-dimensional arrays ofμm-sized traps confining zero-dimensional light-matter polariton fluids and GHz phonons. A strong exciton-mediated polariton-phonon interaction induces a time-dependent inter-site polariton couplingJ(t) with remarkable consequences for the dynamics. When locally perturbed by continuous wave optical excitation, a mechanical self-oscillation sets-in and polaritons respond by locking the energy detuning between neighbor sites at integer multiples of the phonon energy, evidencing asynchronous locking involving the polariton and phonon fields. These results open the path for the coherent control of dissipative quantum light fluids with hypersound in a scalable platform.
Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling
Authors: Roy Michael J. , Surudoi Minglyanna G. , Kropp Ashleigh , Hou Jianmei , Dai Weiwen , Hardy Joshua M. , Liang Lung-Yu , Cotton Thomas R. , Lechtenberg Bernhard C. , Dite Toby A. , Ma Xiuquan , Daly Roger J. , Patel Onisha , Lucet Isabelle S.
Published: June 2023

PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their expression level is associated with several aggressive cancers. Here, we elucidate the molecular details of key PEAK signaling interactions with the adapter proteins CrkII and Grb2 and the scaffold protein 14-3-3. Our findings rationalize why the dimerization of PEAK proteins has a crucial function in signal transduction and provide biophysical and structural data to unravel binding specificity within the PEAK interactome. We identify a conserved high affinity 14-3-3 motif on PEAK3 and demonstrate its role as a molecular switch to regulate CrkII binding and signaling via Grb2. Together, our studies provide a detailed structural snapshot of PEAK interaction networks and further elucidate how PEAK proteins, especially PEAK3, act as dynamic scaffolds that exploit adapter proteins to control signal transduction in cell growth/motility and cancer.
Convergent evolution of plant pattern recognition receptors sensing cysteine-rich patterns from three microbial kingdoms
Authors: Yang Yuankun , Steidele Christina E. , Rössner Clemens , Löffelhardt Birgit , Kolb Dagmar , Leisen Thomas , Zhang Weiguo , Ludwig Christina , Felix Georg , Seidl Michael F. , Becker Annette , Nürnberger Thorsten , Hahn Matthias , Gust Bertolt , Gross Harald , Hückelhoven Ralph , Gust Andrea A.
Published: June 2023

The Arabidopsis thaliana Receptor-Like Protein RLP30 contributes to immunity against the fungal pathogen Sclerotinia sclerotiorum. Here we identify the RLP30-ligand as a small cysteine-rich protein (SCP) that occurs in many fungi and oomycetes and is also recognized by the Nicotiana benthamiana RLP RE02. However, RLP30 and RE02 share little sequence similarity and respond to different parts of the native/folded protein. Moreover, some Brassicaceae other than Arabidopsis also respond to a linear SCP peptide instead of the folded protein, suggesting that SCP is an eminent immune target that led to the convergent evolution of distinct immune receptors in plants. Surprisingly, RLP30 shows a second ligand specificity for a SCP-nonhomologous protein secreted by bacterial Pseudomonads. RLP30 expression in N. tabacum results in quantitatively lower susceptibility to bacterial, fungal and oomycete pathogens, thus demonstrating that detection of immunogenic patterns by Arabidopsis RLP30 is involved in defense against pathogens from three microbial kingdoms.
Exceptionally high charge mobility in phthalocyanine-based poly(benzimidazobenzophenanthroline)-ladder-type two-dimensional conjugated polymers
Authors: Wang Mingchao , Fu Shuai , Petkov Petko , Fu Yubin , Zhang Zhitao , Liu Yannan , Ma Ji , Chen Guangbo , Gali Sai Manoj , Gao Lei , Lu Yang , Paasch Silvia , Zhong Haixia , Steinrück Hans-Peter , Cánovas Enrique , Brunner Eike , Beljonne David , Bonn Mischa , Wang Hai I. , Dong Renhao , Feng Xinliang
Published: June 2023

Two-dimensional conjugated polymers (2DCPs), composed of multiple strands of linear conjugated polymers with extended in-plane π-conjugation, are emerging crystalline semiconducting polymers for organic (opto)electronics. They are represented by two-dimensional π-conjugated covalent organic frameworks, which typically suffer from poor π-conjugation and thus low charge carrier mobilities. Here we overcome this limitation by demonstrating two semiconducting phthalocyanine-based poly(benzimidazobenzophenanthroline)-ladder-type 2DCPs (2DCP-MPc, with M = Cu or Ni), which are constructed from octaaminophthalocyaninato metal(ii) and naphthalenetetracarboxylic dianhydride by polycondensation under solvothermal conditions. The 2DCP-MPcs exhibit optical bandgaps of ~1.3 eV with highly delocalized π-electrons. Density functional theory calculations unveil strongly dispersive energy bands with small electron–hole reduced effective masses of ~0.15m0 for the layer-stacked 2DCP-MPcs. Terahertz spectroscopy reveals the band transport of Drude-type free carriers in 2DCP-MPcs with exceptionally high sum mobility of electrons and holes of ~970 cm2 V−1 s−1 at room temperature, surpassing that of the reported linear conjugated polymers and 2DCPs. This work highlights the critical role of effective conjugation in enhancing the charge transport properties of 2DCPs and the great potential of high-mobility 2DCPs for future (opto)electronics.
Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia
Authors: Kim Jaeseung C. , Chan-Seng-Yue Michelle , Ge Sabrina , Zeng Andy G. X. , Ng Karen , Gan Olga I. , Garcia-Prat Laura , Flores-Figueroa Eugenia , Woo Tristan , Zhang Amy Xin Wei , Arruda Andrea , Chithambaram Shivapriya , Dobson Stephanie M. , Khoo Amanda , Khan Shahbaz , Ibrahimova Narmin , George Ann , Tierens Anne , Hitzler Johann , Kislinger Thomas , Dick John E. , McPherson John D. , Minden Mark D. , Notta Faiyaz
Published: June 2023

In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors (TKIs), especially in the absence of kinase domain mutations in BCR-ABL1, is poorly understood. Through deep molecular profiling, we uncovered three transcriptomic subtypes of BCR-ABL1 lymphoblastic leukemia, each representing a maturation arrest at a stage of B-cell progenitor differentiation. An earlier arrest was associated with lineage promiscuity, treatment refractoriness and poor patient outcomes. A later arrest was associated with lineage fidelity, durable leukemia remissions and improved patient outcomes. Each maturation arrest was marked by specific genomic events that control different transition points in B-cell development. Interestingly, these events were absent in BCR-ABL1+ preleukemic stem cells isolated from patients regardless of subtype, which supports that transcriptomic phenotypes are determined downstream of the leukemia-initialing event. Overall, our data indicate that treatment response and TKI efficacy are unexpected outcomes of the differentiation stage at which this leukemia transforms.
Lactation-associated macrophages exist in murine mammary tissue and human milk
Authors: Cansever Dilay , Petrova Ekaterina , Krishnarajah Sinduya , Mussak Caroline , Welsh Christina A. , Mildenberger Wiebke , Mulder Kevin , Kreiner Victor , Roussel Elsa , Stifter Sebastian A. , Andreadou Myrto , Zwicky Pascale , Jurado Nicole Puertas , Rehrauer Hubert , Tan Ge , Liu Zhaoyuan , Blériot Camille , Ronchi Francesca , Macpherson Andrew J. , Ginhoux Florent , Natalucci Giancarlo , Becher Burkhard , Greter Melanie
Published: June 2023

Macrophages are involved in immune defense, organogenesis and tissue homeostasis. Macrophages contribute to the different phases of mammary gland remodeling during development, pregnancy and involution postlactation. Less is known about the dynamics of mammary gland macrophages in the lactation stage. Here, we describe a macrophage population present during lactation in mice. By multiparameter flow cytometry and single-cell RNA sequencing, we identified a lactation-induced CD11c+CX3CR1+Dectin-1+ macrophage population (liMac) that was distinct from the two resident F4/80hi and F4/80lo macrophage subsets present pregestationally. LiMacs were predominantly monocyte-derived and expanded by proliferation in situ concomitant with nursing. LiMacs developed independently of IL-34, but required CSF-1 signaling and were partly microbiota-dependent. Locally, they resided adjacent to the basal cells of the alveoli and extravasated into the milk. We found several macrophage subsets in human milk that resembled liMacs. Collectively, these findings reveal the emergence of unique macrophages in the mammary gland and milk during lactation.
Delineation of partial melts and crustal heterogeneities within the crust beneath Kumaon Himalaya, India from Lg wave attenuation
Authors: Parija Mahesh Prasad , Kumar Sudesh , V H Arjun
Published: June 2023

The crustal seismic attenuation or the Q structure is studied by using the Fourier spectra of Lg-wave along the Tanakpur- Dharchula- Dharma transect in the Kumaon Himalaya. The 1 Hz Lg Q (Q0) values are computed between different pairs of two stations and the observed values are later utilized to calculate the lateral variation in the Q0 values by following a back projection algorithm. This computation of Q0 values utilizes five regional distance earthquakes having moment magnitude (Mw) ≥ 4.0, which lie along the great circle path of the transect. Three of the five earthquakes occurred in the Tibetan plateau and the and the others occurred to the southwest on the Indian shield and are well recorded at all the 32 broadband seismographs operated between September 2018 and March 2022. The estimate Qo values range from 63 ± 2 and 203 ± 25, with the lowest value in the Lesser Himalaya and the highest across part of the Indo Gangetic Plain and Siwalik Himalaya. The Q0 model has low values ∼200 along the profile in the Indo Gangetic Plain and the Siwalik Himalaya, and are correlated with 2–5 km thick sedimentary layers below the Himalaya and the adjoining Indo-Gangetic Plain. We observe two distinctly different Q0 values to the northeast in the Lesser Himalaya tectonic unit. The region lying between the South Almora Thrust (SAT) and the Berinag Thrust (BT) shows extremely low Q0 values (∼60) but increases further north towards the Vaikrita Thrust (VT) to ∼200. The possible explanation for observing such huge variation of the Q0 values within a single tectonic unit may be the presence of fluid rich ramp structures, which introduces crustal heterogeneities and traps the aqueous fluids or partial melts lying within the crust. The Lg Q0 values decrease to the North and become ∼166 for station pairs in the Higher Himalaya and Tethys Himalaya tectonic units. The low Q0 values observed in this region may be correlated with low viscous partial melts in the form of Miocene leucogranite plutons, which resulted out of the Indo-Asian collision. The attenuation structure along the profile in the Kumaon Himalaya can be used to estimate ground motions of future earthquakes in the area and can contribute to seismic hazard assessment in the Himalaya and neighbouring regions.
Machine learning algorithms for predicting days of high incidence for out-of-hospital cardiac arrest
Authors: Shimada-Sammori Kaoru , Shimada Tadanaga , Miura Rie E. , Kawaguchi Rui , Yamao Yasuo , Oshima Taku , Oami Takehiko , Tomita Keisuke , Shinozaki Koichiro , Nakada Taka-aki
Published: June 2023

Predicting out-of-hospital cardiac arrest (OHCA) events might improve outcomes of OHCA patients. We hypothesized that machine learning algorithms using meteorological information would predict OHCA incidences. We used the Japanese population-based repository database of OHCA and weather information. The Tokyo data (2005–2012) was used as the training cohort and datasets of the top six populated prefectures (2013–2015) as the test. Eight various algorithms were evaluated to predict the high-incidence OHCA days, defined as the daily events exceeding 75% tile of our dataset, using meteorological and chronological values: temperature, humidity, air pressure, months, days, national holidays, the day before the holidays, the day after the holidays, and New Year’s holidays. Additionally, we evaluated the contribution of each feature by Shapley Additive exPlanations (SHAP) values. The training cohort included 96,597 OHCA patients. The eXtreme Gradient Boosting (XGBoost) had the highest area under the receiver operating curve (AUROC) of 0.906 (95% confidence interval; 0.868–0.944). In the test cohorts, the XGBoost algorithms also had high AUROC (0.862–0.923). The SHAP values indicated that the “mean temperature on the previous day” impacted the most on the model. Algorithms using machine learning with meteorological and chronological information could predict OHCA events accurately.
Middle-shallow feature aggregation in multimodality for face anti-spoofing
Authors: Li Chunyan , Li Zhiyong , Sun Jianhong , Li Rui
Published: June 2023

At present, most advanced algorithms for face anti-spoofing use stacked convolutions and residual structure to obtain complex characteristics of deep networks, and then distinguish liveness and deception. These methods ignore the shallow features that contain more detailed information. As a result, the model lacks sufficient fine-grained information, which affects the accuracy and robustness of the algorithm. In this paper, we use the simple features of the shallow network to increase the fine-grained information of the model, so as to improve the performance of the algorithm. First of all, the shallow features are spliced to the middle layer by "shortcut" structure to reserve more details for the middle layer features and improve their detail representation ability. Secondly, the network is initialized with the best pre-trained model parameters under unbalanced samples, and then trained on the balanced samples to improve the classification ability of the model. Finally, RS Block based on depthwise separable convolution is used to replace res module, and model parameters and floating point operations are reduced from 18G and 61 M to 1.9 M and 347 M. The algorithm is simulated on CASIA-SURF dataset, and the results show that the average classification error rate (ACER) is only 0.0008, TPR@FPR = 10E−4 reaches 0.9990, which is better than the previous face anti deception methods.
A comparison of machine learning methods to classify radioactive elements using prompt-gamma-ray neutron activation data
Authors: Mathew Jino , Kshirsagar Rohit , Abidin Dzariff Z. , Griffin James , Kanarachos Stratis , James Jithin , Alamaniotis Miltiadis , Fitzpatrick Michael E.
Published: June 2023

The detection of illicit radiological materials is critical to establishing a robust second line of defence in nuclear security. Neutron-capture prompt-gamma activation analysis (PGAA) can be used to detect multiple radioactive materials across the entire Periodic Table. However, long detection times and a high rate of false positives pose a significant hindrance in the deployment of PGAA-based systems to identify the presence of illicit substances in nuclear forensics. In the present work, six different machine-learning algorithms were developed to classify radioactive elements based on the PGAA energy spectra. The model performance was evaluated using standard classification metrics and trend curves with an emphasis on comparing the effectiveness of algorithms that are best suited for classifying imbalanced datasets. We analyse the classification performance based on Precision, Recall, F1-score, Specificity, Confusion matrix, ROC-AUC curves, and Geometric Mean Score (GMS) measures. The tree-based algorithms (Decision Trees, Random Forest and AdaBoost) have consistently outperformed Support Vector Machine and K-Nearest Neighbours. Based on the results presented, AdaBoost is the preferred classifier to analyse data containing PGAA spectral information due to the high recall and minimal false negatives reported in the minority class.
Malaria surveillance, outbreak investigation, response and its determinant factors in Waghemra Zone, Northeast Ethiopia: unmatched case–control study
Authors: Debash Habtu , Nigatie Marye , Bisetegn Habtye , Feleke Daniel Getacher , Tesfaw Gebru , Amha Askale , Abate Megbaru Alemu , Gedefie Alemu
Published: June 2023

Malaria is a major global public health concern, with around half of the world's population at risk of infection. It is one of the most common epidemic-prone diseases, resulting in on-going epidemics and significant public health problems. On September 12, 2022, Waghemra Zone malaria monitoring data revealed that the district was suffering an unusually high number of malaria cases. Therefore, the aim of this study was to assess the occurrence of malaria outbreaks and investigate contracting factors in Waghemra Zone, Northeast Ethiopia. A community-based case–control study with a 1:1 ratio was employed at Waghemra Zone from September 14 to November 27, 2022. A total of 260 individuals (130 cases and 130 controls) were included in the study. A structured questionnaire was used to collect the data. Malaria cases were confirmed by either microscopy or malaria rapid diagnostic tests. The magnitude of the outbreak was described by place, person, and time. A multivariable logistic regression analysis was conducted to identify malaria risk factors. A total of 13,136 confirmed cases of malaria were detected in the Waghemra zone, with an overall attack rate of 26.5 per 1000 and slide positivity rate was 43.0%. The predominant species was Plasmodium falciparum accounting for 66.1%. Children under five years old (AOR = 5.1; 95% CI 2.6–23.0), the presence of artificial water-holding bodies (AOR: 2.7; 95% CI 1.340–5.420), intermittent rivers closer to the living house (AOR = 4.9; 95% CI 2.51–9.62), sleeping outside a home (AOR = 4.9; 95% CI 2.51–9.62), and a lack of knowledge about malaria transmission and prevention (AOR: 9.7; 95% CI 4.459–20.930) were factors associated with malaria contraction. The overall attack rate for malaria during this outbreak was high. Children less than five years, the presence of mosquito breeding sites, staying outdoors overnight, and a lack of knowledge on malaria transmission and prevention were predictors of malaria. Early management of local vector breeding places, as well as adequate health education on malaria transmission and prevention methods, should be provided to the community to prevent such outbreaks in the future.
Responses of yield, quality and water use efficiency of potato grown under different drip irrigation and nitrogen levels
Authors: Akkamis Mustafa , Caliskan Sevgi
Published: June 2023

Proper irrigation and fertilization are essential for achieve high tuber yield and quality in potato production. However, the high cost of these inputs necessitate optimization of their use to improve both water use efficiency and crop productivity. This study aimed to investigate the impact of irrigation and nitrogen fertilization on potato yield, quality and water use efficiency. The research included different drip irrigation treatments (100%, 66%, and 33% of field capacity) and nitrogen levels: 0 (N0), 100 (N1), 200 (N2), 300 (N3), 400 (N4) and 500 (N5) kg N ha−1. The results indicated that potato yield and growth were more sensitive to irrigation treatment than nitrogen levels. Full irrigation with 300 kg N ha−1 produced the highest total tuber yield, while low irrigation treatments resulted in significantly lower yields. In contrast, the 66% field capacity irrigation treatment consistently had the highest water use efficiency in both years of the study. Furthermore, the study showed that the quality characteristics of the tubers were negatively impacted by full irrigation treatments compared to low irrigation. These findings suggest that with appropriate irrigation and nitrogen application, potatoes can be produced with acceptable yields while conserving water and minimizing nitrogen use. This research emphasizes the importance of optimizing inputs to improve water use efficiency and yield productivity while reducing water. As a result, obtaining useful information on crop management for farmers to make informed decisions may be possible by achieving optimal irrigation and nitrogen levels.
Comparison of automated quantification of amyloid deposition between PMOD and Heuron
Authors: Roh Hyun Woong , Son Sang Joon , Hong Chang Hyung , Moon So Young , Lee Sun Min , Seo Sang Won , Choi Seong Hye , Kim Eun-Joo , Cho Soo Hyun , Kim Byeong Chae , Park Seongbeom , Song Soohwa , An Young-Sil
Published: June 2023

Several programs are widely used for clinical and research purposes to automatically quantify the degree of amyloid deposition in the brain using positron emission tomography (PET) images. Given that very few studies have investigated the use of Heuron, a PET image quantification software approved for clinical use, this study aimed to compare amyloid deposition values quantified from 18F-flutemetamol PET images using PMOD and Heuron. Amyloid PET data obtained from 408 patients were analysed using each quantitative program; moreover, the standardized uptake value ratios (SUVRs) of target areas were obtained by dividing the standardized uptake value (SUV) of the target region by the SUV of cerebellar grey matter as a reference. Compared with PMOD, Heuron yielded significantly higher SUVRs for all target areas (paired sample t-test, p < 0.001), except for the PC/PCC (p = 0.986). However, the Bland–Altman plot analysis indicated that the two quantitative methods may be used interchangeably. Moreover, receiver operating characteristic curve analysis revealed no significant between-method difference in the performance of the SUVRs in evaluating the visual positivity of amyloid deposits (p = 0.948). In conclusion, Heuron and PMOD have comparable performance in quantifying the degree of amyloid deposits in PET images.
The effects of propolis on pro-oxidant–antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial
Authors: Anvarifard Paniz , Ostadrahimi Alireza , Ardalan Mohammadreza , Anbari Maryam , Ghoreishi Zohreh
Published: June 2023

Chronic kidney disease (CKD) is a progressive kidney damage with an increasing prevalence. Some evidence suggests that propolis as a novel antioxidant, anti-inflammatory, and immunomodulatory agent may have beneficial effects in CKD. The aim of this study was to evaluate the efficacy of propolis on some kidney function parameters, pro-oxidant–antioxidant balance (PAB), glycemic status, quality of life, and blood pressure (BP) in patients with CKD. In this study, 44 patients with CKD were randomly assigned to receive propolis capsules at a dose of 250 mg daily or placebo for three months. Of 44 randomized individuals, 35 completed the trial. At the end of the intervention (end of month three), improvement in some dimensions of health-related quality of life (HRQoL) (derived from Kidney Disease and Quality of Life Short-Form (KDQOL-$${\mathrm{SF}}^{\mathrm{TM}}$$

SF

TM

, v. 1.3) questionnaire) were significantly higher in the propolis group than the placebo group, even after adjustment for baseline values, present of diabetes, and age (P < 0.05). Like systolic and diastolic BP, changes in serum creatinine, 24-h urine volume and protein, fasting blood sugar (FBS), hemoglobin A1C (HbA1C), insulin, homeostasis model of assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and PAB did not differ significantly between the two groups (P > 0.05). No serious adverse events were reported throughout the study. Propolis supplementation may improve the HRQoL of CKD patients. More studies are needed to validate the adjunct use of propolis for metabolic control of CKD patients.
Microplastics in snow from protected areas in Hokkaido, the northern island of Japan
Authors: Ohno Hiroshi , Iizuka Yoshinori
Published: June 2023

Snowfall is regarded as a carrier of airborne microplastics (MPs). Deposited snow can function as a temporary reservoir for atmospheric MPs. Nevertheless, knowledge and understanding of MPs in snow remain sparse. This study investigates the abundance, composition, size (> 30 µm), and shape of MPs in snow specimens from various nature preservation areas and also from urban sites in Hokkaido. Various polymeric-type MPs with mostly fragmentary shapes were detected among the specimens. More than half of MPs were in the smallest size class (30–60 µm), implying the presence of more MPs below the limit (< 30 µm). Concentrations of MPs ranged from 1.5 × 102 to 4.2 × 103 particles/L. The results demonstrated that microplastic abundance generally decreases concomitantly with increasing remoteness of sampling sites. Observed features of MPs at different locations and their relation to geographical settings have indicated that the ubiquitously observed fine particles (mainly alkyd, ethylene–vinyl acetate, and polyethylene) are attributable to long-distance atmospheric transportation, whereas the rubber and larger particles especially found near highways and cities are from local sources of plastic. Taken together, these findings suggest important implications for elucidating the nature and distribution of atmospheric MPs.
A power allocation strategy for fuel cell ship considering fuel cell performance difference
Authors: Cao Wei , Geng Pan , Xu Xiaoyan , Guo Yi , Ma Zhanxin
Published: June 2023

This paper focuses on designing a power allocation strategy for a fuel cell ship. The performance of the fuel cell varies during operation, so a power allocation strategy considering fuel cell performance differences is proposed, which consists of two layers. In the first layer, the maximum power and maximum efficiency of each fuel cell system (FCS) are updated in real-time with an online parameter identification model, which is composed of the fuel cell semi-empirical model and adaptive Kalman filter. The second layer takes the state of charge of the battery energy storage system, the maximum power, and the maximum efficiency as inputs for power allocation. Compared with the equal allocation strategy and daisy chain strategy, the total hydrogen consumption reduces by 5.3% and 15.1% and the total output power of the FCS with poor performance reduces by 14.1% and 15.7%. The results show that the proposed method can improve the efficiency of the ship power system and reduce the operational burden of the FCS with poor performance.
Effects of high-intensity focused ultrasound combined with levonorgestrel-releasing intrauterine system on patients with adenomyosis
Authors: Cai Yuru , Sun Yanan , Xu Feng , Wu Yunzhe , Ren Chunfeng , Hao Xiaohong , Gao Bulang , Cao Qinying
Published: June 2023

It is very important to treat adenomyosis which may cause infertility, menorrhagia, and dysmenorrhea for women at the reproductive age. High-intensity focused ultrasound (HIFU) is effective in destroying target tumor tissues without damaging the path of the ultrasound beam and surrounding normal tissues. The levonorgestrel-releasing intrauterine system (LN-IUS) is a medical system which is inserted into the uterine to provide medicinal treatment for temporary control of the symptoms caused by adenomyosis. This study was to investigate the effect of HIFU combined with the LN-IUS on adenomyosis. In the HIFU treatment, the parameters of the ultrasound were transmission frequency 0.8 MHz and input power 50–400 W (350 ± 30), and the temperature in the target tissue under these conditions would reach 60–100 °C (85 °C ± 6.3 °C). Size reduction and blood flow signal decrease were used to assess the effect of combined treatment. In this study, 131 patients with adenomyosis treated with HIFU combined with LN-IUS were retrospectively enrolled. The clinical and follow-up data were analyzed. After treatment, the volume of the uterine lesion was significantly decreased with an effective rate of 72.1%, and the adenomyosis blood flow signals were significantly reduced, with an effective rate of 71.3%. At six months, the menstrual cycle was significantly (P < 0.05) decreased from 31.4 ± 3.5 days before treatment to 28.6 ± 1.9 days, the menstrual period was significantly shortened from 7.9 ± 1.2 days before HIFU to 6.5 ± 1.3 days, and the menstrual volume was significantly (P < 0.05) decreased from 100 to 49% ± 13%. The serum hemoglobin significantly (P < 0.05) increased from 90.8 ± 6.2 g/L before treatment to 121.6 ± 10.8 g/L at six months for patients with anemia. Among seventy-two (92.3%) patients who finished the six-month follow-up, sixty-five (90.3%) patients had the dysmenorrhea completely relieved, and the other seven (9.7%) patients had only slight dysmenorrhea which did not affect their daily life. Adverse events occurred in 24 (18.3%) patients without causing severe consequences, including skin burns in two (1.5%) patients, skin swelling in four (3.1%), mild lower abdominal pain and low fever in 15 (11.5%), and subcutaneous induration in three (2.3%). Six months after treatment, no other serious side effects occurred in any patients with follow-up. In conclusions, the use of high-intensity focused ultrasound combined with the levonorgestrel-releasing intrauterine system for the treatment of adenomyosis is safe and effective even though the long-term effect remains to be confirmed.