bluuebunny/crossref_metadata_2025 huggingface dataset:
Eryngium caeruleum: an update on ethnobotany, phytochemistry and biomedical applications
Authors: Konovalov Dmitryi Alexeevich , Cáceres Edgardo Avendaño , Shcherbakova Ekaterina Aleksandrovna , Herrera-Bravo Jesús , Chandran Deepak , Martorell Miquel , Hasan Muzaffar , Kumar Manoj , Bakrim Saad , Bouyahya Abdelhakim , Cho William C. , Sharifi-Rad Javad , Suleria Hafiz A. R. , Calina Daniela
Published: September 2022

Background

A biennial or perennial plant of the Apiaceae family, Eryngium caeruleum M. Bieb. is traditionally used in medicine as an antitoxic, diuretic, digestive, anti-inflammatory and analgesic drug. This plant is widely distributed in temperate regions around the world. Young leaves of the plant are used in cooking as aromatic cooked vegetables in various local products in Iran.

Purpose

The current review aimed to highlight complete and updated information about the Eryngium caeruleum species, regarding botanical, ethnopharmacological, phytochemical data, pharmacological mechanisms as well as some nutritional properties. All this scientific evidence supports the use of this species in complementary medicine, thus opening new therapeutic perspectives for the treatment of some diseases.

Methods

The information provided in this updated review is collected from several scientific databases such as PubMed/Medline, ScienceDirect, Mendeley, Scopus, Web of Science and Google Scholar. Ethnopharmacology books and various professional websites were also researched.

Results

The phytochemical composition of the aerial parts and roots of E. caeruleum is represented by the components of essential oil (EO), phenolic compounds, saponins, protein, amino acids, fiber, carbohydrates, and mineral elements. The antioxidant, antimicrobial, antidiabetic, antihypoxic, and anti-inflammatory properties of E. caeruleum have been confirmed by pharmacological experiments with extracts using in vitro and in vivo methods. The syrup E. caeruleum relieved dysmenorrhea as effectively as Ibuprofen in the blinded, randomized, placebo-controlled clinical study.

Conclusion

Current evidence from experimental pharmacological studies has shown that the different bioactive compounds present in the species E. caeruleum have multiple beneficial effects on human health, being potentially active in the treatment of many diseases. Thus, the traditional uses of this species are supported based on evidence. In future, translational and human clinical studies are necessary to establish effective therapeutic doses in humans.
Iranian future healthcare professionals' knowledge and opinions about rare diseases: cross-sectional study
Authors: Jahanshahi Reza , Nasirzadeh Amirreza , Farzan Mahan , Domaradzki Jan , Jouybari Leila , Sanagoo Akram , Farzan Mahour , Aghazadeh-Habashi Komeil , Fallah Faraghe Ahmadreza , Bagheri Sadegh , Samiee Marziyeh , Ansari Arina , Eskandari Kimia , Namakkoobi Negar , Soltanimoghadam Fatemeh , Mashali Hadi , Yavari Erfan , Bay Saba , Memaripanah Nafiseh , Meftah Elahe , Amanzadeh Saeed , Talati Fatemeh , Bahramzadeh Sasan
Published: September 2022

Background

Rare diseases are a new global health priority, requiring evidence-based estimates of the global prevalence of diseases to inform public policymakers and provide a serious challenge to the healthcare system that must not be ignored. The purpose of this study is to investigate Iranian future healthcare professionals' knowledge and opinions about rare diseases.

Results

A total of 6838 students responded to the questionnaire. Nursing and medical students had the highest participation. Almost 85% of participants rated their knowledge about rare diseases as poor or insufficient. While nearly 70 percent of participants took courses about rare diseases at university. Finally, 72.7% of future healthcare professionals did not feel ready to take care of a patient with a rare disease.

Conclusion

The present study has indicated a gap in Iranian medical students’ knowledge of rare diseases. The researchers believe that health science policymakers should make a joint effort to improve knowledge about rare diseases. Including courses with regard to rare diseases would be of benefit to future healthcare professionals.
Structural stigma and its impact on healthcare for borderline personality disorder: a scoping review
Authors: Klein Pauline , Fairweather A. Kate , Lawn Sharon
Published: September 2022

Background

People with Borderline Personality Disorder (BPD) and their carers/families continue to experience structural stigma when accessing health services. Structural stigma involves societal-level conditions, cultural norms, and organizational policies that inhibit the opportunities, resources, and wellbeing of people living with attributes that are the object of stigma. BPD is a serious mental illness characterized by pervasive psychosocial dysfunction including, problems regulating emotions and suicidality. This scoping review aimed to identify, map, and explore the international literature on structural stigma associated with BPD and its impact on healthcare for consumers with BPD, their carers/families, and health practitioners.

Methods

A comprehensive search of the literature encompassed MEDLINE, CINAHL, PsycINFO, Scopus, Cochrane Library, and JBI Evidence-Based databases (from inception to February 28th 2022). The search strategy also included grey literature searches and handsearching the references of included studies. Eligibility criteria included citations relevant to structural stigma associated with BPD and health and crisis care services. Quality appraisal of included citations were completed using the Mixed Methods Appraisal Tool 2018 version (MMAT v.18), the Joanna Briggs Institute (JBI) Checklist for Systematic Reviews and Research Syntheses Tool, and the AGREE II: advancing guideline development, reporting, and evaluation in health care tool. Thematic Analysis was used to inform data extraction, analysis, interpretation, and synthesis of the data.

Results

A total of 57 citations were included in the review comprising empirical peer-reviewed articles (n = 55), and reports (n = 2). Studies included quantitative, qualitative, mixed methods, and systematic review designs. Review findings identified several extant macro- and micro-level structural mechanisms, challenges, and barriers contributing to BPD-related stigma in health systems. These structural factors have a substantial impact on health service access and care for BPD. Key themes that emerged from the data comprised: structural stigma and the BPD diagnosis and BPD-related stigma surrounding health and crisis care services.

Conclusion

Narrative synthesis of the findings provide evidence about the impact of structural stigma on healthcare for BPD. It is anticipated that results of this review will inform future research, policy, and practice to address BPD-related stigma in health systems, as well as approaches for improving the delivery of responsive health services and care for consumers with BPD and their carers/families.

Review Registration: Open Science Framework (https://osf.io/bhpg4).
Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer
Authors: Jia Yongxu , Yan Qian , Zheng Yinli , Li Lei , Zhang Baifeng , Chang Zhiwei , Wang Zehua , Tang Hong , Qin Yanru , Guan Xin-Yuan
Published: September 2022

Background

Lymph node metastasis is one of most common determinants of the stage and prognosis of gastric cancer (GC). However, the key molecular events and mechanisms mediating lymph node metastasis remain elusive.

Methods

RNA sequencing was used to identify driver genes responsible for lymph node metastasis in four cases of gastric primary tumors, metastatic lesions of lymph nodes and matched normal gastric epithelial tissue. qRT–PCR and IHC were applied to examine RPRD1B expression. Metastatic functions were evaluated in vitro and in vivo. RNA-seq was used to identify target genes. ChIP, EMSA and dual luciferase reporter assays were conducted to identify the binding sites of target genes. Co-IP, RIP, MeRIP, RNA-FISH and ubiquitin assays were applied to explore the underlying mechanisms.

Results

The top 8 target genes (RPRD1B, MAP4K4, MCM2, TOPBP1, FRMD8, KBTBD2, ADAM10 and CXCR4) that were significantly upregulated in metastatic lymph nodes of individuals with GC were screened. The transcriptional cofactor RPRD1B (regulation of nuclear pre-mRNA domain containing 1B) was selected for further characterization. The clinical analysis showed that RPRD1B was significantly overexpressed in metastatic lymph nodes and associated with poor outcomes in patients with GC. The Mettl3-induced m6A modification was involved in the upregulation of RPRD1B. Functionally, RPRD1B promoted lymph node metastasis capabilities in vitro and in vivo. Mechanistic studies indicated that RPRD1B increased fatty acid uptake and synthesis by transcriptionally upregulating c-Jun/c-Fos and activating the c-Jun/c-Fos/SREBP1 axis. In addition, NEAT1 was upregulated significantly by c-Jun/c-Fos in RPRD1B-overexpressing cells. NEAT1, in turn, increased the stability of the RPRD1B mRNA by recruiting the m6A “reader” protein hnRNPA2B1 and reduced the degradation of the RPRD1B protein by inhibiting TRIM25-mediated ubiquitination. Notably, this functional circuitry was disrupted by an inhibitor of c-Jun/c-Fos/AP1 proteins (SR11302) and small interfering RNAs targeting NEAT1, leading to a preferential impairment of lymph node metastasis.

Conclusions

Based on these findings, RPRD1B facilitated FA metabolism and assisted primary tumor implantation in lymph nodes via the c-Jun/c-Fos/SREBP1 axis, which was enhanced by a NEAT1-mediated positive feedback loop, serving as a potential therapeutic target for GC treatment.
Factors impacting participation in research during the COVID-19 pandemic: results from a survey of patients in the ophthalmology outpatient department
Authors: Abdulhussein Dalia , Yap Timothy E. , Manzar Haider , Miodragovic Serge , Cordeiro Francesca
Published: September 2022

Background

Understanding public and patient attitudes to clinical research is paramount to successful recruitment. The COVID-19 pandemic has led to additional hurdles in achieving this. Our aim is to understand the current factors and attitudes towards clinical trial participation in order to assist in recruitment to clinical trials.

Methods

We conducted face-to-face interviews with patients in the outpatient department at a tertiary eye hospital facilitated by a 32-item questionnaire developed by the research team. Patient characteristics were correlated with their responses, in addition to qualitative thematic text analysis.

Results

A total of 53 patients were interviewed. Forty per cent indicated that they would be willing to participate in clinical research in the current climate. General motivating factors for involvement in research included personal gain, altruism and contribution to innovation. Factors limiting participation included concerns regarding own safety, inconvenience, accessibility and lack of benefit. 22.6% of participants felt that the COVID-19 pandemic has changed their outlook on research. These were categorised into positive (increased awareness of the importance and need for research, altruism) and negative (increased anxiety, need to minimise exposure to the hospital environment) influences.

Conclusions

Factors influencing patients’ decisions to participate in trials are similar to those observed prior to COVID-19 but with an increased focus on the environment the research is conducted in. The COVID-19 pandemic has had positive and negative impacts on patient attitudes towards research. Trial design, with a particular focus on setting and safety measures, in reassuring patients is increasingly important.
Unconditional superconvergence analysis of an energy-stable finite element scheme for nonlinear Benjamin–Bona–Mahony–Burgers equation
Authors: Wang Lele , Liao Xin , Yang Huaijun
Published: September 2022

In this paper, an energy-stable Crank–Nicolson fully discrete finite element scheme is proposed for the Benjamin–Bona–Mahony–Burgers equation. Firstly, the stability of energy is proved, which leads to the boundedness of the finite element solution in $H^{1}$

H
1

-norm. Secondly, combining with the above boundedness and the special property of bilinear element, the unconditional superclose and superconvergence results are derived. Finally, numerical examples are provided to illustrate the validity and efficiency of our theoretical analysis and method.
Four-step approach to idea management sequencing: redefining or reinventing values in a business model
Authors: Mikelsone Elina , Uvarova Inga , Segers Jean-Pierre
Published: September 2022

The purpose of this paper is to create and test an idea management sequence framework to reinvent or redefine the value proposition. Idea management with sequencing activities must be considered as a systematic managerial process and should not be confused with the occasional result of an individual with a design thinking mindset. This paper suggests a new approach—a systematic, 4-step idea management sequence to redefine or reinvent value proposition in a business model, which was validated through an action-based research method involving 20 managers from practice by applying the proposed framework. Based on the idea management approach, authors describe the idea generation and evaluation processes and their possible moderation elements. This research contributes to previous studies of the design thinking and innovation by substantiating a concept of the idea management sequencing and proposing a new 4-step approach that can be applied by organisations to redefine or reinvent value proposition in their business models. Being influenced by pandemic restrictions and the full or partial remote workforce, the 4-step idea management approach is beneficial for virtual group sessions as it increases the quality of outcomes, engagement of individuals, collaborative openness, and confidence.
Electronic monitoring of doffing using video surveillance to minimise error rate and increase safety at Howard Springs International Quarantine Facility
Authors: Curtis Stephanie J. , Trewin Abigail , McDermott Kathleen , Were Karen , Clezy Kate , Dempsey Kathy , Walsh Nick
Published: September 2022

Background

Safe donning and doffing of personal protective equipment (PPE) are critical to prevent transmission of infectious diseases. Novel strategies to improve infection prevention and control (IPC) adherence can optimise safety. We describe and quantify video surveillance of doffing at an outdoor hotel quarantine facility led by the Australian Medical Assistance Team in the Northern Territory, Australia.

Methods

Motion-activated video cameras were installed in seven areas where personnel doffed PPE upon exit from an area dedicated to quarantined residents. Video footage was reviewed daily and compliance issues were identified using a standardised checklist and risk graded to initiate feedback. We collated audit data from 1 February to 18 April 2021 to describe trends by month, staff group, doffing component and risk.

Results

In 235 h of video footage, 364 compliance issues were identified, of which none were considered high-risk compromising to PPE integrity. Compliance issues were low risk (55/364, 15%) or moderate risk (309/364, 85%) and the most common issue was missed or inadequate hand hygiene (156/364, 43%). Compliance issues per minute of video footage reviewed decreased following introduction of the activity, from 24 per 1000 in February to 7 per 1000 in March and April.

Conclusion

Video surveillance with feedback supported rapid response to improve IPC adherence in a challenging ambient environment. The activity focused on perfection to identify compliance issues that would go unreported in most healthcare settings and contributed to a suit of activities that prevented any high-risk PPE breaches or compromises to safety.
Adalimumab for induction of remission in patients with Crohn's disease: a systematic review and meta-analysis
Authors: Yin Juntao , Li Yang , Chen Yangyang , Wang Chaoyang , Song Xiaoyong
Published: September 2022

Purpose

A large number of people with Crohn's disease (CD) fail to recover from conventional therapy or biological therapy. Some studies showed that adalimumab (ADA) may be an effective alternative therapy for these patients. The aim of this study was to evaluate the efficacy and safety of ADA in inducing CD remission.

Methods

We performed search of Pubmed/MEDLINE, Embase, CENTRAL, the Cochrane IBD Group Specialized Register, and several other databases. Randomized controlled trials (RCTs) comparing any dose of ADA with controls (placebo or active) in participants with active CD were included. The primary outcome was the failure to achieve clinical response/remission at 4 weeks. Several subgroup and sensitivity analyses were performed. Review Manager Software v5.3 was used.

Results

Four RCTs were included (n = 919), in which 553 participants received ADA and 366 participants received placebo. A meta-analysis of four studies showed that at 4 weeks, there were more people in the ADA group with clinical response/remission or symptom improvement compared with the placebo group. The rates of side effects, serious side effects, and study withdrawals due to side effects were lower in ADA participants than placebo ones.

Conclusion

This meta-analysis shows that ADA is superior to placebo in induction of clinical response/remission of CD patients, but no firm conclusions can be drawn on the safety of ADA in CD due to the low number of events.

Graphical Abstract
Evaluation of mortality prediction using SOFA and APACHE IV tools in trauma and non-trauma patients admitted to the ICU
Authors: Karami Niaz Mehran , Fard Moghadam Nazanin , Aghaei Abbas , Mardokhi Saeed , Sobhani Somayeh
Published: September 2022

Background

Various tools have previously been introduced to predict the recuperation and mortality of patients in intensive care units and to classify them, which have particular advantages and disadvantages compared to each other. The present study compared the prediction power of mortality of trauma and non-trauma patients admitted to the ICU by SOFA and APACHE IV tools.

Methods

In this retrospective cohort study, patients admitted to the ICU of Kowsar Hospital in Sanandaj from the beginning of April 2020 to the end of December 2020 were assessed. Data were collected in the form of a questionnaire based on APACHE IV and SOFA criteria as well as the demographic information questionnaire. All collected data related to the first 24 h of patients' hospitalization was analyzed in SPSS V16 software using Chi-square, Mann–Whitney, Cox regression and Pearson correlation coefficient.

Results

This study was performed on 404 patients admitted to the ICU, Out of which 273 people (67.6%) were male, 208 (51.5%) trauma patients and 196 (48.5%) non-trauma ones. Patients’ mean age was 54.76 ± 20.77 years and their average length of stay in the hospital was 10.05 ± 8.49 days. In general, the AUC obtained by APACHE IV tool (0.902) was slightly better than that of SOFA tool (0.895). However, in a specific study of traumatic and non-traumatic patients, it was found that APACHE IV and SOFA tools had better performance in predicting death innon-trauma and trauma patients based on the accuracy, AUC and sensitivity, respectively.

Conclusions

Based on the results of this study, the difference between APACHE IV and SOFA tools in predicting death of patients admitted to the ICU was very small but the function of APACHE IV was better in predicting mortality of non-traumatic patients, while the function of SOFA was better in predicting the death of traumatic cases. This represents the applicability of these two tools in different patient subgroups.
Preliminary evaluation of the online course “I Care” targeting eating disorder knowledge and attitudes among sports coaches and fitness instructors
Authors: Selenius Sofia , Birgegård Andreas , Forsén Mantilla Emma
Published: September 2022

Background

Fitness instructors, coaches and trainers are often looked up to and seen as role-models within their sporting community. Since problematic exercise is a common symptom of eating disorders, they are also highly likely to meet individuals at risk for developing eating disorders within their profession. Thus, educating coaches about how to promote healthy ideals within their sports/training context and equipping them with knowledge to be able to detect and approach individuals at risk, is of great importance.

Method

We studied the pre-to-post effects of the I Care online psychoeducational intervention in 150 coaches, trainers, and fitness instructors. Variables included the Compulsive Exercise Test, as well as knowledge of eating disorders, and confidence and awareness regarding approaching, talking to, and referring individuals whose observed behavior raised concerns.

Results

Results showed significant and large improvements in coaches’ confidence and knowledge regarding warning signs and how to approach an at-risk person, and a decrease in their perceived ability to recognize eating disorders by sight, e.g., insight about EDs not being recognizable just by looking at a person. Also, significant positive change in attitudes about their own rule-driven exercise behavior and lack of enjoyment of exercise was observed.

Conclusions

Although the lack of a control group compels caution, the study suggests that I Care may have positive effects in terms of a “declaration of intent” toward more positive role-modeling and interactions with clients.
β-Hydroxyphosphocarnitine modifies fibrosis, steatosis and improves liver function in non-alcoholic steatohepatitis induced in rats
Authors: Sánchez-Quevedo Janet , Ocampo-Rodríguez Emmanuel , Alvarez-Ayala Elizabeth , Rodríguez-López Anahí , Duarte-Vázquez Miguel Angel , Rosado Jorge Luis , Rodríguez-Fragoso Lourdes
Published: September 2022

Background

Non-alcoholic steatohepatitis (NASH) is a chronic disease characterized by inflammation, steatosis, and liver fibrosis. The liver is particularly affected by alterations in lipid metabolism. Our aim was to evaluate the effect of β-hydroxyphosphocarnitine (β-HPC) on NASH induced in rats.

Methods

NASH was produced via the ad libitum daily chronic administration of a fructose solution (400 kcal) for 9 weeks, an oral dose of fat solution (16 kcal) for 7 weeks and a subcutaneous injection of CCl4 (30%) two times a week for 2 weeks to Wistar rats. To evaluate the effect of β-HPC, a dose of 100 mg/kg was administered perorally for 4 weeks and its biochemical and hepatic effects on rats with NASH were analyzed. Serum levels of glucose, triglycerides, cholesterol, and liver enzymes were quantified. Histological changes were evaluated on slices stained with H&E, trichromic and PAS. Glycogen content was measured in liver samples. α-SMA and SREBP-1 immunopositive cells were identified in liver tissue.

Results

NASH was characterized by elevated triglycerides, elevated liver damage enzymes, and the presence of necrosis, inflammation, steatosis, and fibrosis. Significant amounts of glycogen were found, along with α-SMA positive cells in fibrosis areas. The over-expression of SREBP-1 in cytoplasm and nuclei was evident. Animals with NASH treated with β-HPC showed a significant reduction in inflammation, necrosis, and glycogen content in the liver. A reduction in α-SMA and SREBP-1 immunopositive cells correlated with a significant reduction in the degree of fibrosis and steatosis found in liver tissue. β-HPC reduced the levels of ALP and GGT, and significantly reduced triglyceride levels. Animals treated with β-HPC did not show any alterations in liver enzyme function.

Conclusions

Our research shows that β-HPC can improve liver function and morphology in the case of NASH induced in rats, suggesting β-HPC could be potentially used in the treatment of NASH.
Determination of streptomycin residues in imported and locally produced honey in Kosovo
Authors: Rama Adem , Haziri Imer , Miftari Iliriana , Zuka Afërdita , Zhuri Blend , Latifi Arlind , Hasani Drilon , Latifi Fatgzim
Published: September 2022

Although bee honey is considered an essential and healthy food for humans, honey can be affected by various contaminants, such as antibiotics, that can cause health problems for consumers. The objective of this study was to assess the occurrence of streptomycin residues in locally produced and imported bee honey, which was collected in 2017 from individual apiaries and retail markets in six different regions of Kosovo. In the present study, 155 bee honey samples were qualitatively screened by the enzyme-linked immunosorbent assay (ELISA) method using an I'screen STREPTO test kit (Tecna S. r. L., Trieste, Italy) as a simple and fast method. Descriptive statistics were used to outline the essential characteristics of the sample and mass; 29% of samples were contaminated with streptomycin at concentrations between 2.1-9.3 ug/kg, while 71% of the samples were found to be negative for streptomycin. Most of the samples with streptomycin residues were from the Ferizaj and Prizren regions. Based on these results, competent authorities should establish and maintain programs to continuously monitor honey to ensure that consumers in Kosovo receive risk-free honey. In addition, there is a pressing need for additional research to accurately assess other aspects of this problem and identify effective corrective actions that will reduce contaminants in bee honey.
Basiliximab for early perioperative transplant-associated thrombotic microangiopathy after lung transplantation: a case report
Authors: Ijiri Naohiro , Sato Masaaki , Konoeda Chihiro , Nagayama Kazuhiro , Nakajima Jun
Published: September 2022

Background

Thrombotic microangiopathy is a syndrome characterized by microangiopathic hemolytic anemia and platelet aggregation, which is caused by endothelial injury, microcirculation thrombosis, and fibrin deposition. Transplant-associated thrombotic microangiopathy rarely occurs after lung transplantation and the onset is generally later than that after bone marrow or other solid organ transplantation. The treatment is to stop administration of the causal agent, which is often a calcineurin inhibitor, such as tacrolimus and cyclosporine. We herein report the case of a patient with early post-transplant thrombotic microangiopathy after lung transplantation treated by introducing basiliximab and temporarily stopping any calcineurin inhibitors until resuming treatment with an alternative calcineurin inhibitor.

Case presentation

A 58-year-old Asian woman underwent bilateral lung transplantation for hypersensitivity pneumonitis caused by an avian antigen, or bird fancier’s lung disease. Postoperatively, she was started on triple immunosuppressive therapy, which included tacrolimus, mycophenolate mofetil, and steroids. On postoperative day 6, she developed thrombocytopenia followed by fever, hemolytic anemia, renal dysfunction, and purpura on her limbs and abdomen. She was diagnosed with transplant-associated thrombotic microangiopathy, and tacrolimus was thought to be the causal agent. We stopped tacrolimus and administered basiliximab. Then, she developed oliguria and needed continuous hemodiafiltration. On postoperative day 14, the platelet count recovered and she was switched from basiliximab to cyclosporine. Using this protocol, worsening thrombotic microangiopathy and acute rejection were avoided.

Conclusions

We report the case of a patient with early post-transplant thrombotic microangiopathy after lung transplantation that was treated with basiliximab. Switching from calcineurin inhibitors using basiliximab may be an option for treating thrombotic microangiopathy without increasing the risk of acute rejection.
S. mediterranea ETS-1 regulates the function of cathepsin-positive cells and the epidermal lineage landscape via basement membrane remodeling
Authors: Dubey Vinay Kumar , Sarkar Souradeep R. , Lakshmanan Vairavan , Dalmeida Rimple , Gulyani Akash , Palakodeti Dasaradhi
Published: September 2022

Extracellular matrix (ECM) is an important component of stem cell niche. Remodeling of ECM mediated by ECM regulators, such as matrix metalloproteinases (MMPs) plays a vital role in stem cell function. However, the mechanisms that modulate the function of ECM regulators in the stem cell niche are understudied. Here, we explored the role of the transcription factor (TF) ETS-1, which is expressed in the cathepsin-positive cell population, in regulating the expression of the ECM regulator, mt-mmpA, thereby modulating basement membrane thickness. In planarians, the basement membrane around the gut/inner parenchyma is thought to act as a niche for pluripotent stem cells. It has been shown that the early epidermal progenitors migrate outwards from this region and progressively differentiate to maintain the terminal epidermis. Our data shows that thickening of the basement membrane in the absence of ets-1 results in defective migration of stem cell progeny. Furthermore, the absence of ets-1 leads to a defective epidermal progenitor landscape, despite its lack of expression in those cell types. Together, our results demonstrate the active role of ECM remodeling in regulating tissue homeostasis and regeneration in the planarian Schmidtea mediterranea.

This article has an associated First Person interview with one of the co-first authors of the paper.
Mouthpart adaptations of antlion larvae facilitate prey handling and fluid feeding in sandy habitats
Authors: Lehnert Matthew S. , Lanba Asheesh , Reiter Kristen E. , Fonseca Rena J. , Minninger Jordan , Hall Benjamin , Huff Wesley
Published: September 2022

Antlion larvae are fluid-feeding ambush predators that feed on arthropods trapped in their funnel-shaped pits built in sandy habitats; however, details are lacking about their feeding mechanism. Here, we tested the hypothesis that the antlion, Myrmeleon crudelis, has adaptations that facilitate fluid feeding in sandy habitats. We measured contact angles of water droplets and used the capillary-rise technique to assess mouthpart wettability. A structural organization was discovered that provides a hydrophobic–hydrophilic wetting dichotomy that simultaneously supports self-cleaning and fluid uptake and is enabled by antiparallel movements of the maxillae. The mouthparts also are augmented by their mechanical properties, including maxillae and mandible tips that might be heavily sclerotized, as determined by confocal microscopy, which likely facilitates piercing prey. Our findings provide insight into how antlion larvae have overcome the challenges of fluid feeding in sandy habitats, which probably contributed to their success and widespread distribution.
Η συμφωνία ως πεδίο εφαρμογής σύγχρονων αισθητικών αντιλήψεων και μέσο έκφρασης νέων αναζητήσεων
Authors: Αποστόλου Παναγιώτης
Published: September 2022

Το παρόν πόνημα εξετάζει τη συμφωνία ως πολύτιμο και διαχρονικό συνθετικό εργαλείο, ως πεδίο εφαρμογής σύγχρονων αισθητικών αντιλήψεων, καθώς και ως μέσο έκφρασης νέων αναζητήσεων. Εστιάζει πρωτίστως στην πρωτότυπη μουσική δημιουργία σχετικού έργου και της ανάλυσής του. Παράλληλα, αφουγκράζεται παγκόσμια ιστορικά δεδομένα της εξελικτικής πορείας του είδους και τη θέση της σύγχρονης ελληνικής δημιουργίας.
Evaluation of the relationship between dermatoglyphics and mandibular third molar impaction: A cross-sectional study
Authors: Kapoor Ashish , Shetty Premalatha , Shetty Sameep S. , N. Srikant , Aggarwal Nancy , Merchant Yash , Riahi Seyed Mohammed
Published: September 2022

Background: Dermatoglyphics can be utilised in clinical settings to identify those who are more likely to have impacted teeth. Additionally, dermatoglyphics looks to have potential as a non-invasive diagnostic method for predicting the presence or absence of an impacted tooth. The goal of this study was to look at the most common dermatoglyphic pattern in people who had or didn't have an impacted mandibular third molar teeth and see if there was a dermatoglyphic signature.

Methods: A cross-sectional study with 180 participants was conducted (90 cases and 90 controls). The rolling impression technique was used to apply blue duplicating ink to participants' fingertips, which was then recorded. There was an increase in the frequency of the whorl-plain pattern in the right-hand ring finger (60%; p=0.028) and left-hand little finger (33.3%; p=0.009), as well as the loop-ulnar pattern in the right-hand middle finger (74.4%; p=0.024) in individuals with a predisposition to the presence of impacted teeth.

Results: The left-hand little finger was found to be the most predictive for impaction in a forward stepwise binary logistic regression analysis.

Conclusions: Dermatoglyphics could be used as a non-invasive sign to predict whether or not a tooth is affected. Its value comes in early detection, which helps to avoid the surgical problems that come with symptomatic extraction of an impacted tooth.
Kondratieff Cycles in the Economy of India and China
Authors: Basovskaya Elena , Basovskiy Leonid
Published: September 2022

The Kondratieff cycles in the economy of India and China are determined. We used time series of real per capita GNP. The study carried out by constructing econo-metric models that include a cyclical component. Modeling made it possible to establish the Kondratyev cycles in the national production and give the periodization of the Kon-dratyev cycles in the national production of India and China. The upward half-wave of the fourth Kondratieff cycle appeared in India in 1984 and in China in 1964. An up-ward half-wave of the fifth Kondratyev cycle in India expected in 2032. The upward half-wave of the fifth Kondratyev cycle in China occurred in 2010. India currently dominated by the fourth technological; the transition to the dominance of the fifth tech-nological order can be expected in 2032. China currently dominated by the fifth techno-logical order. It be considered justified the possibility of leadership in the world econo-my of China. There is not enough reason to assume the possibility of India's passage to leadership in the world economy in the middle of the 21st century.
Development of measures of municipal programs for the improvement of the territory, maintenance of life and satisfaction of the needs of residents
Authors: Suslova A.
Published: September 2022

The article gives a brief description of the tasks and goals of municipal programs within the framework of the improvement of the territories of the municipality of Tula for 2021. The results of the analysis of the distribution of funding from the local budget between the tasks of municipal programs of five territorial districts of the city of Tula are presented. The system of indicators (indicators) used to assess the results of the implementation of improvement programs is considered. The problems of the implementation of these municipal programs are highlighted on the basis of a comparative analysis of planned and actual indicators.
Instytucje miejskie jako wyznaczniki przynależności w czasach przednowoczesnych? Rozważania na przykładzie górnofrankońskiego miasta Seßlach
Authors: Schröder Lina
Published: September 2022

W badaniu indywidualnej przynależności w czasach przednowoczesnych termin ‘obywatelstwo’ jest bezużyteczny. Zamiast tego można mówić o ‘potrójnej przynależności’: indywidualnej przynależności do (1) władzy zwierzchniej, (2) gminy kościelnej oraz (3) stanu lub warstwy. Zagadnienie to można zbadać z pomocą instytucji komunalnych – zostało to zademonstrowane w artykule na przykładzie miasta Seßlach i jego trzech instytucji. Tłumaczenie Renata Skowrońska
Drogi awansu senatorskiego Adama Chmary, Leonarda Świeykowskiego i Gedeona Jeleńskiego w czasach stanisławowskich. Przyczynek do dyskusji
Authors: Rolnik Dariusz
Published: September 2022

Tekst ukazuje zmiany zachodzące w sposobach awansowania do godności senatorskich w Rzeczypospolitej czasów stanisławowskich (1764–1795) oraz przyjmowanych przy tym kryteriach. Prezentuje przy tym sposób myślenia elit o Rzeczypospolitej i pojęciu obywatelstwa. Wskazane przykłady karier sugerują (mimo pewnych wątpliwości), że na karierę mogły liczyć osoby, które okazywały zainteresowanie dobrem kraju i województwa, a zarazem ideologicznie popierały program naprawy Rzeczypospolitej króla Stanisława Augusta. Kryteriami awansu stawały się zdolności, talenty konkretnych osób, a nie klientelna służba bądź przynależność do znamienitej rodziny. Była to droga do budowy nowoczesnego społeczeństwa, w którym o karierze decydują charakter i zdolności, a nie „błękitna” krew lub układy klientelne.
We wspólnym świecie : studia o myśli, wyobraźni i postawie społecznej Cypriana Norwida
Authors: Ziołowicz Agnieszka
Published: September 2022

IN A COMMON WORLD. STUDIES ON CYPRIAN NORWID’S THOUGHT, IMAGINATION AND SOCIAL ATTITUDE We wspólnym świecie. Studia o myśli, wyobraźni i postawie społecznej Cypriana Norwida [In a Common World. Studies on Cyprian Norwid’s Thought, Imagination and Social Attitude] is a monographic treatment of the notion of the common world in Cyprian Norwid’s works. This issue is reflected in the writer’s entire output, and evoked by means of various philosophical and ethical traditions, interpretations of community life, particular role models as well as the social behaviour and artistic gestures of the writer himself. Equally diverse here are the media used to transmit the sense of community. These include poetry in its different variants, artistic and journalistic prose, drama, epistolography and public addresses. From this varied source material a description of Norwid’s original understanding of the common world emerges in the course of interdisciplinary analyses taking into account the findings of the history of ideas, philosophy, sociology, theology and above all the history of literature and culture of the 19th century. The volume comprises a series of closely related studies, divided into three parts: Spotkania u źródeł [Encounters at the sources], Norwidowska paideia [Norwid’s paideia], Żywe słowo [Spoken word].
The Screening Role of Design Parameters for Service Procurement Auctions in Online Service Outsourcing Platforms
Authors: Liang Chen , Hong Yili , Chen Pei-Yu , Shao Benjamin B. M.
Published: September 2022

This paper provides a novel theoretical angle and robust empirical evidence demonstrating that the auction duration and the item description length are two essential auction design parameters that can function as screening mechanisms for bidder quality on online service outsourcing platforms. These outsourcing platforms use buyer-determined reverse auctions to find service providers. Using data from a major online outsourcing platform, we examine the effects of the auction duration and the item description length on both bidder entry (i.e., the number of bids and bidder quality) and contract outcomes (i.e., whether a project is contracted and the buyer’s expected utility from the winning bid) based upon the project- and bidder-level analyses. We find that auctions with longer durations and item descriptions attract more bids, but they also attract disproportionately more low-quality bidders, creating a double whammy of higher evaluation costs and adverse selection for buyers. This, in turn, leads to less successful contracting as well as lower buyer utility. Our research highlights the screening role of the auction duration and item description length for buyers on online service outsourcing platforms: by shortening auction durations and item descriptions, buyers can expect higher quality bidders, increase contracting probability, and enhance utility.
Management of parasites of mammalian wildlife in European hedgehogs (Erinaceus europaeus)
Authors: Wright Ian
Published: September 2022

Wild European hedgehogs are frequent visitors to domestic gardens and as a result, injured and debilitated animals are often found by the public and brought into veterinary surgeries for treatment and rehabilitation. One of the aspects of this process that is overlooked is the ecto and endoparasites they carry. Parasite burdens are likely to be high in diseased patients and may contribute to disease syndromes or cause primary disease in their own right. Some also have limited zoonotic potential. Veterinary nurses need to be able to help the veterinary surgeon diagnose parasitic infections in hedgehog patients and assess their significance. This article summarises the most common parasites of hedgehogs that are likely to be encountered, their diagnosis and management.
Internal conflict in the workplace
Authors: Broekes Belinda
Published: September 2022

Conflict in a veterinary practice is generally perceived as between animal owner and veterinary staff, however this is limited research on the internal conflict within practice. This article provides a high level overview of the different styles of conflict and also what strategies may be available in order to improve the working relationship from an employer and employee perspective.
Molecular characterization of porcine parvovirus 1 based on partial VP2 gene in the ovaries of Thai pigs
Authors:   Division of Veterinary Paraclinic, Department of Veterinary Bioscience and Veterinary public Health, Faculty of Veterinary medicine, Chiang Mai University, Tumbon Maehea, Amphoe Maung, Chiang Mai 50100 Thailand, Saekhow Prayuth , Sriphannam Chayaphon ,   Department of Biochemistry, Faculty of Medical Science, Naresuan University, Tumbon Tha Pho, Amphoe Maung, Phitsanulok, 65000 Thailand., Yamsakul Panuwat ,   Swine Clinic, Department of Food Animal Clinics, Faculty of Veterinary medicine, Chiang Mai University, Tumbon Maehea, Amphoe Maung, Chiang Mai 50100 Thailand
Published: September 2022

Porcine parvovirus 1 (PPV1) is the causative agent of swine reproductive disease, particularly in naive gilts and sows. This study aimed to investigate the prevalence and genetic diversity of the partial nucleotide sequence of the VP2 gene and to compare the substitution of amino acid residues that affect relevant biological properties. The prevalence of PPV1 was found to be 12% (12/100) when the viral genome was detected using polymerase chain reaction (PCR). Determination of the genetic diversity of a partial nucleotide sequence of the VP2 gene through phylogenetic analysis indicated that a single cluster of Thai PPV1s was allocated on the phylogenetic tree. According to a comparison of the substitution of amino acid residues that affected the biological properties at 378, 383, 365, and 436 of the VP2 capsid protein between the 12 Thai PPV1s, the Kresse strain (a surrogate pathogenic strain), and the NADL-2 strain (a surrogate nonpathogenic strain). It was determined that the substitution of amino acid residues at 378, 383, and 436 of 12 Thai PPV2s was identical to those of the Kresse strains. The substitution of amino acid residues at 436 of the 12 Thai PPV1s was similar to that of a proven virulent strain in vivo. Additionally, substituting amino acid residue at 320 of the VP2 capsid protein revealed that seven Thai PPV1s were associated with isoleucine PPV1s and identical to that of both surrogate strains, whereas five Thai PPV1s were associated with threonine. This outcome was similar to what had been deposited in GenBank. Our data suggest that Thai PPV1s isolated from the ovaries of pigs raised in Chiang Mai may have originated from the Kresse strains. Based on a change of VP2 capsid protein that occurred amongst the substitution amino acid residue at 320 of the VP2 capsid protein, viruses found in this region were determined to be similar to those found in other areas. This was likely because the viruses had adapted to evade the immune systems of animals.
The effect of different media and temperature conditions for Salmonella bacteriophage preservation
Authors:   Agricultural Service Center, Department of Agriculture and Rural Development, Can Tho City, Vietnam Department of Veterinary Medicine, College of Agriculture, Can Tho University, Vietnam, Le Nguyen Nam Phuong , Luu Huynh Anh ,   Department of Animal Sciences, College of Agriculture, Can Tho University, Vietnam, Pham Khanh Nguyen Huan ,   Department of Biology, College of Natural Sciences, Can Tho University, Vietnam, Huynh Tan Loc ,   Department of Veterinary Medicine, College of Agriculture, Can Tho University, Vietnam, Chau Thi Huyen Trang ,   Department of Veterinary Medicine, College of Agriculture, Can Tho University, Vietnam, Trinh Thi Hong Mo ,   Applied Biology Faculty, Tay Do University, Can Tho City, Vietnam, Nguyen Hong Xuan ,   College of Food Technology and Biotechnology, Can Tho University of Technology, Can Tho City, Vietnam, Nguyen Trong Ngu ,   Department of Veterinary Medicine, College of Agriculture, Can Tho University, Vietnam
Published: September 2022

This research aimed to determine the optimal media and temperature conditions for the long-term storage of bacteriophages. In this study, the viability of Salmonella phages in 50% glycerol, 10% sodium chloride-magnesium sulfate (SM) buffer, and 5% dimethyl sulfoxide (DMSO) media at room temperature, 4oC, -20oC, and -80oC for 12 months was determined. In 50% glycerol, at the end of the experiment, no significant difference was found between four temperature conditions on phage density, ranging from 6.20-6.23 log10 PFU/mL (P>0.05). Under 10% SM medium, phage preservation at room temperature provided the optimum density at 6.31 log10 PFU/mL. In addition, phages preserved in a 5% DMSO medium were of similar density values across all temperature treatments. Still, their availability after 12 month-storage (88.0-88.5%) was significantly lower (P<0.05) than that of 50% glycerol and 10% SM. Moreover, for phage lysis capacity, low temperatures (4oC, -20oC, and -80oC) were superior to room temperature used for preservation. Considering the density, lysis capacity, and practical convenience, storing phages at 4°C in a 50% Glycerol medium is recommended.
Epidemiology and Antimicrobial Resistance of Salmonella Isolated from Racehorses and Horsemen in Northeastern Thailand
Authors:   Veterinary Hospital, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand, Dejkong Ruxpon , Wattanachai Suchat ,   Division of Surgery and Theriogenology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand, Phuektes Patchara ,   Division of Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand, Putthachalee Suphannika ,   Division of Surgery and Theriogenology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand, Angkititrakul Sunpetch ,   Division of Veterinary Public Health, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
Published: September 2022

Salmonella is one of the major causes of foodborne diseases in humans. These bacteria can colonize within the gastrointestinal tracts of both humans and animals, and there have been reports of incidences of Salmonella in horses. This study aimed to investigate the prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from racehorses and horsemen, as well as to explore the possible transmission between horses and humans. Fecal samples from racehorses (247 samples) and horsemen (33 samples) were collected from horse farms located in 3 provinces of upper Northeastern Thailand between March and August 2019. Salmonella was isolated and identified. Broth microdilution was used to determine the minimal inhibitory concentrations (MICs) of the antimicrobial agents for antimicrobial. Salmonella isolates were detected in 4.86% (12/247) of racehorses and 3.03% (1/33) of horsemen. The most commonly found serotypes in the isolates obtained from the racehorses were Abony (25%) and Iganda (16.67%). Only the Tumodi II serotype was found in one horseman. Salmonella isolates collected from the racehorses had been the most resistant to streptomycin (66.67%), while the isolate from a horsemen had been resistant to ampicillin, streptomycin, oxytetracycline, and to tetracycline. Although Salmonella transmission between racehorses and horsemen was not found to be obviously present in this study, the appropriate use of antimicrobials and hygienic procedures are still necessary in order to prevent antimicrobial resistance and the transmission of drug-resistant Salmonella between horses and humans.