bluuebunny/crossref_metadata_2025 huggingface dataset:
Estranhamento de si
Authors: Maranhão Andreia Pagani , Moraes Betânea Moreira
Published: October 2020

O “Estranhamento de si” é apresentado como um híbrido entre a esfera psicossomática e político-econômica, na qual o adoecimento aparece como sintoma da exploração produtiva e disciplinamento dos sujeitos. Espera-se delinear a sociogênese do processo e sua etiologia funcional ao desenvolvimento do sistema. A partir dos dados encontrados, evidencia-se a estrutura social da psicossomatização e identificam-se possibilidades de reinvenção das praxis de cuidado nas racionalidades integrativas da saúde.
Problems of treatment adherence in patients with rheumatoid arthritis and comorbidity
Authors: Nikitina N. M. , Egorova E. V. , Melehina I. F. , Grigoryeva S. N. , Rebrov A. P.
Published: October 2020

Aim of the study. Evaluation of treatment adherence in patients with rheumatoid arthritis (RA) and comorbidity.

Materials and methods. One hundred thirty-two women (mean age: 55.5 ± 10.5 years) with proven RA (mean duration of disease: 10.2 [4; 14] years) were included in this study. Patients with moderate and high disease activity were prevalent (average DAS28: 5.0 [4.3; 5.8]). All patients had comorbidities. All patients underwent clinical examination, laboratory evaluation and imaging. Functional capacity was assessed using the Steinbroker classification (functional class — FC) and Stanford Health Assessment Questionnaire (HAQ). Pain severity was evaluated using visual analog scale (VAS). Patients’ social status was assessed. Baseline adherence to treatment was evaluated using two questionnaires. Morisky-Green questionnaire was used to evaluate general adherence to treatment among 132 (100%) patients. Quantitative evaluation of treatment adherence was performed in 82 (62.1%) patients using N.A. Nikolaev questionnaire.

Results. Analysis of adherence to treatment as assessed by Morisky-Green questionnaire has established that 68 (52.3%) of patients are non-adherent to treatment. Low treatment adherence as assessed by Nikolaev questionnaire was found in 33 (40.3%) of patients. Lifestyle modification was characterized by lowest adherence. Young age, lower duration of disease and lower income were predictive of higher adherence to treatment. Non-adherent patients had higher RA activity index and lower functional capacity.

Conclusion. Simultaneous use of several methods to assess treatment adherence is a reasonable way to get more information about the patient and to implement therapy as planned. Evaluation of baseline adherence to treatment among patients with rheumatoid arthritis allows to develop an optimal plan for follow-up and treatment control.
Pengaruh Metode Pembelajaran Dan Kecerdasan Interpersonal Terhadap Kompetensi Komunikasi Terapeutik Mahasiswa Program DIII Kebidanan Stikes Mitra Ria Husada Cibubur
Authors: Martha Dina , Hartati Hartati , Syahrial Zulfiati
Published: October 2020

This study aims to determine the method of learning and interpersonal intelligence to therapeutic communication competence of DIII students Obstetrics STIKes Mitra RIA Husada. Learning methods are placed on bedside teaching methods, coaching methods and demonstrations. The method used in this research is experiment with treatment design level 3 x 2 with sample 48 student. The summary of this research is: 1) Bedside teaching methods can improve therapeutic communication better than coaching methods and methods of demonstration; 2) Coaching learning method can improve therapeutic communication better than demonstration; 3) The existence of interaction between learning method and intelligent interpersonal to therapeutic communication competence; 4) students who have high interpersonal intelligence, more appropriate use of bedside teaching methods; 5) students who have low interpersonal intelligence, more appropriate use of coaching learning methods than the method of demonstration.
Perbaikan Kinerja Guru Madrasah Ibtidaiyah: Pelatihanan, Perancangan, dan Pendampingan
Authors: Yaumi Muhammad
Published: October 2020

The purposes of this study were to increase teachers' understanding of multiple intelligences through learner-centered approach, improve teachersâ€™ performance in designing learner characteristics-oriented instruction, and improve teachersâ€™ performance in implementing instruction. This study used action research by using proactive design involving 26 respondents from 10 elementary Madrasah in Gowa, South Sulawesi and 4 collaborators. The methods of data collection were observation, interview, and test. The collected data were analyzed by using a mixed method (qualitative and quantitative). The  results showed that the implementation of training on multiple intelligence based learning proved to increase teachers' understanding of learner centered approach and contribute an average score 32.61% of teachersâ€™ performance improvement, designing multiple intelligences based learning proved to give a contribution of 26.55% to the teachersâ€™ performance improvement, and mentor system proved to give contribution of 23,86% to the teachersâ€™ performance improvement in instructional implementation. It is suggested that the implementation of training should be followed by workshop and training in order to increase teachersâ€™ performance.
Korelasi Hasil UKG SMA Tahun 2015 dengan Hasil UN Matematika SMA Tahun 2016 Daerah Istimewa Yogyakarta
Authors: Sukardjo Moch , Sugiyanta Lipur
Published: October 2020

Penelitian ini bertujuan untuk:(1) menghitung kompetensi guru mata pelajaran Matematika tahun 2015 di DIY, (2) menghitung rata-rata nilai UN Matematika tahun 2016, dan (3) menentukan korelasi antara hasil kompetensi guru Matematika tahun 2015 terhadap hasil UN Matematika tahun 2016. Metode yang digunakan adalah deskriptif kuantitatif dengan rumusan korelasi. Data sekunder berasal dari hasil ujian kompetensi guru  tahun 2015 Dirjen GTK, Kementerian Pendidikan dan Kebudayaan dan data hasil UN tahun 2016 Pusat Penilaian Pendidikan, Badan Penelitian dan Pengembangan, Kementerian Pendidikan dan Kebudayaan.  Populasi seluruh guru Matermatika yang mengikuti UKG tahun 2015  dan seluruh siswa SMA kelas 12  yang mengikuti Ujian Nasional  tahun 2016 dan menggunakan sampel jenuh. Hasil analisis regresi menunjukan bahwa nilai UKG Matematika 2015 tidak mempengaruhi perolehan nilai UN Matematika 2016. Hanya 0,03% nilai UN Matematika 2016 yang ditentukan oleh nilai UKG Matematika 2015. Dari hasil tersebut terlihat bahwa UKG Matematika tahun 2015 belum memiliki dampak terhadap peningkatan UN Matematika pada tahun 2016.
Pengembangan Modul Cetak Pembelajaran Remedial Untuk Peningkatan Ketuntasan Belajar Mata Pelajaran Bahasa Indonesia SMP Kelas VIII
Authors: - Supkarwati , Ibrahim Nurdin , - Priyono
Published: October 2020

Penelitian ini bertujuan untuk menghasilkan modul pembelajaran remedial mata pelajaran Bahasa Indonesia kelas III SMP. Metodologi yang digunakan adalah metologi penelitian pengembangan. Model yang digunakan adalah model Derek Rowntree dengan 3 tahapan, yaitu tahap perencanaan, tahap persiapan penulisan, serta tahap penulisan dan penyuntingan.  Hasil penelitian menunjukkan nilai rata-rata dari ahli materi dan bahasa sebesar 3,8. Hal itu menunjukkan bahwa produk yang dihasilkan sangat bagus. Hasil penelitian oleh ahli desain menunjukkan rata-rata 3,7. Artinya, produk ini sangat bagus. Berdasarkan uji satu-satu, hasil rata-rata sebesar 3,7. Artinya, modul ini hasilnya sangat bagus. Dari uji kelompok kecil, nilai rata-rata post test sebesar 82. Ini berarti modul mampu meningkatkan prestasi hasil belajar remedial dengan. Dari ujicoba lapangan, nilai rata-rata post test sebesar 81. Ini berarti, modul mampu meningkatkan prestasi hasil belajar remedial.

Dapat disimpulan bahwa modul cetak pembelajaran remedial bahasa Indonesia untuk siswa kelas VIII SMP dapat dikatakan bagus untuk pembelajaran remedial.
ШТАММОСПЕЦИФИЧНОСТЬ БАКТЕРИЙ KLEBSIELLA PNEUMONIAE, ИЗОЛИРОВАННЫХ ОТ ПАЦИЕНТОВ С ДИАГНОЗОМ ВНЕБОЛЬНИЧНАЯ ПНЕВМОНИЯ
Authors: Катаева Любовь
Published: October 2020

Представлены результаты кластерного и корреляционного анализа штаммов бактерий K. pneumoniae, изолированных из содержимого нижних дыхательных путей при внебольничной пневмонии от пациентов моноинфекционного госпиталя г. Тюмени.
Analysis of Bioavailable Toluene by Using Recombinant Luminescent Bacterial Biosensors with Different Promoters
Authors: Wang Guey-Horng , Tsai Teh-Hua , Kui Chun-Chi , Cheng Chiu-Yu , Huang Tzu-Ling , Chung Ying-Chien
Published: October 2020

In this study, we constructed recombinant luminescent Escherichia coli with T7, T3, and SP6 promoters inserted between tol and lux genes as toluene biosensors and evaluated their sensitivity, selectivity, and specificity for measuring bioavailable toluene in in groundwater and river water. The luminescence intensity of each biosensor depended on temperature, incubation time, ionic strength, and concentrations of toluene and coexisting organic compounds. Toluene induced the highest luminescence intensity in recombinant lux-expressing E. coli with the T7 promoter [T7-lux-E. coli, limit of detection (LOD) = 0.05 μM], followed by that in E. coli with the T3 promoter (T3-lux-E. coli, LOD = 0.2 μM) and SP6 promoter (SP6-lux-E. coli, LOD = 0.5 μM). Luminescence activities may have been synergistically or antagonistically affected by coexisting organic compounds other than toluene; nevertheless, low concentrations of benzoate and toluene analogs had no such effect. In reproducibility experiments, the biosensors had low relative standard deviation (4.3%–5.8%). SP6-lux-E. coli demonstrated high adaptability to environmental interference. T7-lux-E. coli biosensor—with low LOD, wide measurement range (0.05–500 μM), and acceptable deviation (−14.3% to 9.1%)—is an efficient toluene biosensor. This is the first study evaluating recombinant lux E. coli with different promoters for their potential application in toluene measurement in actual water bodies.
Interactive Participatory Audit and Feedback (IPAF): Theory-based development and multi-site implementation outcomes with specialty clinic staff
Authors: Ramly Edmond , Lauver Diane , Gilmore-Bykovskyi Andrea , Bartels Christie M
Published: October 2020

Background: Theory-based implementation strategies, such as audit and feedback (A&F), can improve adoption of evidence-based practices. However, few strategies have been developed and tested to meet the needs of specialty clinics. In particular, frontline staff can execute CVD risk-reduction protocols, but A&F strategies to support them have not been well examined. Our objective was to develop and evaluate a novel A&F strategy, Interactive Participatory A&F (IPAF). Methods: We developed IPAF by combining theories to inform staff goals (Self-Regulation Theory) and address their psychological needs for relatedness, autonomy, and confidence (Self-Determination Theory). We facilitated IPAF fidelity by developing a theory-based facilitation tool: a semi-structured worksheet to guide flexible discussion of target behaviors, perceived barriers, goals, and action plans. We evaluated IPAF in the context of eight quasi-experimental implementations in specialty clinics across two health systems. Following a Hybrid Type 2 effectiveness-implementation design, we reported intervention outcomes for CVD risk-reduction elsewhere. This paper reports implementation outcomes associated with IPAF, focusing on feasibility, acceptability, fidelity, and adoption. We evaluated implementation outcomes using mixed-methods data including Electronic Health Records (EHR) data, team records, IPAF worksheets, and staff questionnaire responses. Results: Eighteen staff participated in 99 monthly, individual, synchronous (face-to-face or by phone) IPAF sessions during the first six months of implementation. Subsequently, we provided over 375 monthly feedback emails. Feasibility data revealed high staff attendance (90-93%) and engagement in IPAF sessions. Staff rated questionnaire items about acceptability of IPAF highly. IPAF records and staff responses demonstrated fidelity of delivery and receipt of IPAF. Adoption of target behaviors increased significantly (all P-values < 0.05) and was maintained for over 24 months. Conclusions: We developed and evaluated an interactive participatory A&F strategy with frontline staff in specialty clinics to improve implementation of evidence-based interventions. The IPAF toolkit combines two complementary theories: Self-Regulation Theory and Self-Determination Theory. Findings support feasibility, acceptability, and fidelity of IPAF, and staff adoption and maintenance of target behaviors. By evaluating multi-site implementation outcomes, we have extended prior research on clinic protocols and A&F beyond primary care settings and providers.
Contribution of root respiration to total soil respiration during non-growing season in mine reclaimed soil with different covering soil thicknesses
Authors: Chen Min , Chen Xiaoyang , Hu Zhiyong , Fan Tingyu , Zhang Shiwen , Liu Ying
Published: October 2020

An accurate assessment of root respiration in mine reclaimed soil is important for effectively evaluating mining area ecosystem. This study investigated dynamic changes in root respiration and contribution of root respiration to total soil respiration (Rr/Rt ratio) during the non-growth season in mine reclaimed soil with different covering soil thicknesses. According to covering soil thicknesses, the study area was divided into four sites: 10-25 cm (site A), 25-45 cm (site B), 45-55 cm (site C) and 55-65 cm (site D). From November 2017 to April 2018 (except February in 2018), the soil respiration, root respiration, temperature at 5 cm, water content and root biomass were measured. The results showed that soil temperature and root respiration exhibited similar diurnal and monthly variations. The root respiration was strongly influenced by soil temperature during the non-growing season, which showed an exponential and positive relationship with soil temperature (P<0.001). The root respiration varied with the covering soil thickness and was the greatest with the covering soil thickness at 25–45 cm. The Rr/Rt ratio also exhibited monthly variations. During the non-growth season, the mean value of the Rr/Rt ratio were 51.15% in mine reclaimed soil. The study indicated that root respiration was the primary source of soil respiration and important to estimate the potential of emission of soil CO 2 at regional scale in mine reclaimed soil.
Chemosensitivity based on pathologic complete response in very young patients with ER-positive breast cancer: a large, multicenter, observational study
Authors: Woo Joohyun , Oh Se Jeong , Song Jeong-Yoon , Chae Byung Joo , Choi Jung Eun , Lee Jeeyeon , Park Heung Kyu , Society Korean Breast Cancer , Lim Woosung
Published: October 2020

Background In estrogen receptor (ER)-positive breast cancer, young age is associated with poor prognosis. Several reports have suggested hormonal mechanism as the possible reason. Conversely, very young patients respond better to chemotherapy, and chemotherapy is less effective in ER-positive tumors than in ER-negative tumors. The authors tried to evaluate the chemoinsensitivity of very young patients with ER-positive breast cancer by pathologic complete response (pCR) after neoadjuvant chemotherapy excluding the effect of endocrine treatment to the extent possible.Methods We collected individual patient data from 1992 to 2013 from the Korean Breast Cancer Society (KBCS). Total 1,048 ER-positive and 797 ER-negative patients aged <50 years who had been treated with neoadjuvant chemotherapy were included for analysis. We compared the pathologic complete response (pCR) rate between patients aged <35 years with ER-positive tumors and the other groups.Results The proportion of very young patient aged <35years was 14% in ER-positive group and 16.8% in ER-negative group. Although most chracteristics of tumors according to age were comparable in both groups, tumors with high Ki-67 expression were more common in patients under 35years of age than in those aged 35-49years in both groups (P = 0.001). Breast conservation rates were not significantly different according to age in two groups (44.2% vs. 46.8% in ER-positive group, 55.2% vs. 48.0% in ER-negative group). pCR rates of both breasts and axilla were not significantly different according to age in ER-positive group (P=0.71) but significantly better in patients aged <35years in ER-negative group (P=0.009). After adjusting for confounding variables, young patients maintained the higher probability of pCR than older patients in ER-negative tumors. However, the pCR rate did not differ according to age in ER-positive tumors. Conclusions Chemotherapy response based on pCR rates was not better in young patients (<35 years) with ER-positive breast cancer than in older premenopausal patients with ER-positive advanced breast cancer. Young age cannot be a predictive factor of chemosensitivity in ER-positive breast cancer. Different biological characteristics such as high Ki-67 proliferative index should be considered.Trial registration: retrospectively registered
In Vitro Study of Biomechanical Analysis of Modified Lateral Lumbar Interbody Fusion—crenel Lumbar Interbody Fusion
Authors: Chen Yun-lin , Lai Ou-jie , Ma Wei-hu , Ma Yu-li , Pang Jia-ni , Chen Qi-xin
Published: October 2020

Background To analyze the biomechanical stability of the modified LLIF, crenel lateral interbody fusion (CLIF), and compare various methods of instrumentation of CLIF in vitro.Methods Three fresh-frozen cadaveric lumbar spines (L1-S1) were used in our study. The modified CLIF interbody cage was inserted into the L3/4 level in each specimen. Every specimen was tested under 5 conditions: intact group; stand-alone CLIF group; CLIF with lateral plate group (CLIF + LP); CLIF with lateral plate and unilateral pedicle screw group (CLIF + LP + UPS); CLIF with bilateral pedicle screw group (CLIF + BPS).Results The ROM of each CLIF group was significantly reduced when compared with intact group in all directions of loading (p< 0.05). The CLIF + LP + BPS group was the most stable in all directions of loading. CLIF + LP group has less ROM when compared with stand-alone group except for the extension condition. CLIF + BPS group has less ROM than CLIF + LP group in every condition. Conclusions CLIF combine with lateral plate and bilateral pedicel screw is the most stable supplemental fixation, and lateral plate could reduce the ROM under rotation and lateral bending conditions. For patients with good bone quality, stand-alone with or without is a alternative method to achieve a good clinical result.
Identification and characterization of circRNAs in the deposition of intramuscular fat in Aohan fine-wool sheep
Authors: Zhao Le , Liu Nan , Han Fuhui , Zhou Lisheng , Liu Lirong , Wang Lei , Zhao Ranran , Duan Xinming , He Jianning
Published: October 2020

Background

Aohan fine-wool sheep (AFWS) is a high-quality fine-wool sheep breed that supplies both wool and meat. The quality of its meat is affected by many factors. Research is needed on the molecular mechanism of intramuscular fat (IMF) growth, which greatly improves mutton quality. The widely expressed non-coding RNA is used in roles such as competitive endogenous RNAs (ceRNAs), including microRNAs (miRNAs). Although circular RNA (circRNA) was studied in many fields, little research was devoted to IMF in sheep. We used RNA-Seq to analyze tissues associated with IMF in 2-month-old and 12-month-old AFWS rams to understand the role of circRNA in the growth and development of sheep IMF.
Results

A total of 11,565 candidate circRNAs were identified, of which 104 were differentially expressed in the two age groups. We analyzed these differentially expressed circRNAs. Enrichment analysis was performed using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. The enriched pathways included lipid transport (GO:0006869), negative regulation of canonical Wnt signaling pathway (GO:0090090), fat digestion and absorption (ko04975), and sphingolipid metabolism (ko00600). We used the TargetScan and miRanda software programs for interaction analysis, and a network diagram was created. Six circRNAs were randomly selected and verified the RNA-Seq results by quantitative real-time PCR.
Conclusion

This study provides more information on circRNA regulation in AFWS, and is a useful resource for further research on this sheep breed.
Pharmacodynamics of efavirenz 400mg in treatment-naïve Chinese HIV-infected patients in a prospective cohort study
Authors: Xu Ling , Peng Wenxiu , Song Xiaojing , Li Yanling , Han Yang , Zhu Ting , Fu Qiang , Du Xiaoli , Cao Wei , Li Tai-Sheng
Published: October 2020

BackgroundThe plasma concentration of efavirenz (EFV) 600mg dose was found to exceed the upper limit of proposed therapeutic window in most Chinese HIV-infected individuals, thus dosage reduction of EFV to 400mg daily warrant consideration. This study aimed at assessing the pharmacodynamics of EFV 400mg for HIV-infected patients in China. MethodTwenty cART-naïve individuals were enrolled in this study. EFV 400mg combined with tenofovir (TDF) and lamivudine (3TC) as initial antiretroviral regimens were administered for 48 weeks. EFV concentration and T-cell subsets as well as HIV RNA load were evaluated at baseline, 4, 12, 24, 48 weeks. Moreover, the neuropsychiatric adverse effects were also assessed by Hamilton depression scale (HAMD) and Pittsburgh sleep quality index (PSQI).ResultsEighteen males and two females whose median age was 26 (interquartile range [IQR]: 23-32) years completed 48 weeks of follow-up. The median EFV concentration was 1.88 (IQR: 1.54-2.42), 1.74 (IQR: 1.36-1.93), 1.93 (IQR: 1.66-2.22), 1.85 (IQR: 1.54-2.14) mg/L at week 4, 12, 24, 48, respectively. The viral load was 4.59 (IQR: 4.10-5.19) lg copies/mL at baseline and it decreased by 4.6 (IQR: 3.98-5.18) lg copies/mL from baseline to weeks 48. 3 of 20 (15%), 10 of 20 (50.0%), 17 of 20 (85%), 18 of 19 (95%) participants had a plasma viral load less than 50 copies/mL at weeks 4, 12, 24, 48 respectively. The median CD4 cell count was 330 (IQR: 237-410) cells/µL at baseline and it increased to 473 (IQR: 344-574) cells/µL at 48 weeks. The score of HAMD was 5 (IQR: 3-9.8), 3 (IQR: 2.25-4) at baseline and 48 weeks. And the score of PSQI was 4 (IQR: 2-5.8), 3 (IQR: 2-4) at baseline and 48 weeks. Dizziness was the most common event, occurring in 70% patients within the first two weeks of treatment. ConclusionPatients prescribed with EFV 400mg-containing agents demonstrated favorable virological and immunological responses. And the plasma EFV concentration was within the recommended therapeutic range with less adverse reactions. EFV 400mg was effective and safe in Chinese HIV-infected patients.
Evaluating the Implementation of a Pragmatic Person-Centered Communication Tool in the Nursing Home via the RE-AIM Framework.
Authors: Abbott Katherine , Heppner Alexandra , Hicks Nytasia , Hermesch Abigail , VanHaitsma Kimberly
Published: October 2020

Background: Person-centered care (PCC) is a philosophy that recognizes “knowing the person” and honoring individual preferences. The purpose of this study was to evaluate the implementation of a novel PCC communication tool in nursing homes (NH). The tool is based on an assessment of NH resident likes and dislikes via the Preferences for Everyday Living Inventory (PELI), which is an evidenced-based, validated instrument used to enhance the delivery of PCC. The Preferences for Activity and Leisure (PAL) Card was developed to communicate residents’ preferences for leisure and activities across care team members. Methods: Providers were recruited to utilize the recreation and leisure items from the PELI to assess resident important preferences and create PAL Cards for 15-20 residents. Providers collected data aligned with the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, Maintenance). Results: Reach and Adoption: A total of n=43 providers registered and n=26 (60%) providers completed the project. Ownership of participating providers included 54% not for profit, 46% for profit, and 8% government owned with an average star rating of 3.7 (SD 1.1) and a range of 1-5. Effectiveness and Implementation: Participants attempted n=424 PAL Cards and completed n=406. The average acceptability of the intervention measure (AIM) was 4.7 (SD 0.4), intervention appropriateness measure (IAM) was 4.5 (SD 0.5), and feasibility of intervention measure (FIM) was 4.6 (SD 0.5). Maintenance: Providers were able to complete 82% of PAL Card placement over the course of 5 months with few cards going missing (<2%). Conclusion: The majority of providers were successful in implementing PAL Cards for residents and reported the intervention as highly acceptable, appropriate, and feasible. The pragmatic PAL Card intervention can assist nursing home providers in meeting PCC regulations and contribute to building relationships between residents, family, and staff.
A Turbulence Scaling Factor that converts laminar solutions to turbulent solutions
Authors: Onur Huseyin
Published: October 2020

The quest to understand turbulent flows continues to be as important as it was during the previous century.
Present work shows that if a 'laminar' solution to Navier -Stokes equations can be found then skin friction and heat transfer coefficients for the turbulent case can readily be obtained. There is no need for Reynolds averaging and turbulence modelling.
This can be done by defining a turbulence scaling factor which converts 'laminar' diffusivities to turbulent diffusivities. Using turbulent diffusivities in the laminar skin friction coefficient formula and laminar heat transfer coefficient formula gives the corresponding turbulent formula.
Five different test cases with credible experimental measurements have been used to show the success of the present approach. This work also gives the lengths of internally generated turbulent eddies and roughness created
turbulent eddies. If main flow mixes the turbulent eddies , smaller eddies are merged by the larger ones and this is the suggested model for roughness effects which dominates at large Reynolds numbers. A single effective roughness which determines the friction factor has also been obtained and the fractal dimension of turbulence is given as power to Reynolds number. This fractal dimension is in accord with literature for turbulent/non-turbulent interfaces.
Inflammatory Myofibroblastoma Tumor of Intraocular Ciliary Body: A Case Report and Literature Review
Authors: yu he , Tong Nianting , Huang Weiqing , Zhou Zhan Yu
Published: October 2020

Background: IMTs are extremely rare in eyes. This is the first report of a IMT of the ciliary body.Case presentation: A ciliary body tumor was found under slit lamp biomicroscopy in a 55-year-old male first diagnosed with cataract. Then this patient underwent trans-sclera resection via partial lamellar sclerouvectomy and par plans vitrectomy to remove the mass. Hematoxylin and eosin (HE) staining and immunohistochemistry findings showed that the characteristics of the tumor were consistent with inflammatory myofibroblastoma tumor (IMT).Conclusions: we reported a rare case of intraocular IMT, which is confirmed by H&E staining, and IHC positive staining for Vimentin, Desmin and ALK, while negative staining for SMA, S-100, ki-67, CK, CD68, and calponin.
Habitual Tea Consumption and 5-year Incident Metabolic Syndrome Among Older Adults: A Community-based Cohort Study
Authors: liu jieyu , Wang Ruirui , Liu Jinghong , Ma Qinghua , Xu Yong , Pan Chenwei
Published: October 2020

Background: The effect of tea consumption on metabolic syndrome (MetS) remains controversial. The objective of this study is to examine the prospective association of tea consumption with 5-year incident MetS among aged population in China.Methods: This analysis included 3005 Chinese adults aged 60 years or older who were free of MetS at baseline examination. MetS was defined according to the National Cholesterol Education Program-Adult Treatment Panel III. Information regarding tea consumption was collected via an interviewer-administrated questionnaire. The prospective associations between tea consumption at baseline and 5-year incident MetS, as well as its individual components, were assessed by multiple logistic regression models.Results: In multiple logistic regressions, habitual drinkers had a 34% increased risk of developing MetS during the 5-year follow-up period compared with non-habitual drinkers. Correspondingly, 5-year cumulative incidence of MetS was found to be higher in those who drank tea more than 5 times per week as compared with non-habitual drinkers. Among the five major components of MetS, low high-density lipoprotein cholesterol was observed in men, while high body mass index, elevated blood pressure and the presence of diabetes mellitus were significant in women.Conclusions: Habitual tea consumption increased the risk of MetS among older Chinese adults. These findings may add novel knowledge to the current studies regarding the controversial effect of tea consumption on cardiovascular and metabolic health among the aged population.
Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome
Authors: Kim Lynn-Jee , Chalmers Timothy , Smith Greg , Li Catherine , Das Abhirup , Poon Wing Keung Eric , Wang Jun , Tucker Simon , Sinclair David , Quek Lake-Ee , Wu Lindsay
Published: October 2020

Treatment with nicotinamide mononucleotide (NMN) is a prominent strategy to address the age-related decline in nicotinamide adenine dinucleotide (NAD+) levels for maintaining aspects of late-life health. It is assumed that exogenous NMN is directly incorporated into the NAD+ metabolome in mammals via the canonical recycling pathway. Here, we show that NMN can undergo direct deamidation and incorporation via the de novo pathway, which is in part mediated by the gut microbiome. Surprisingly, isotope labelling studies revealed that exogenous NMN treatment potently increased the endogenous production of unlabelled NAD metabolites, suggesting that exogenous NMN impacts the NAD metabolome through indirect means, rather than through its direct incorporation. This included a striking increase in endogenous production of the metabolites nicotinic acid riboside (NaR) and nicotinamide riboside (NR) which was amplified in antibiotics treated animals, suggesting the production of endogenous NaR/NR through altered metabolic flux, enzyme kinetics and/or an as-yet unidentified pathway that interacts with the gut microbiome.
Magnetic Resonance Imaging-based Radiomics Nomogram for Prediction of the Histopathological Grade of Soft Tissue Sarcomas: A Two-center Study
Authors: Yan Ruixin , Hao Dapeng , Li Jie , Liu Jihua , Hou Feng , Chen Haisong , Duan Lisha , Huang Chencui , Wang Hexiang , Yu Tengbo
Published: October 2020

Background: Preoperative prediction of the soft tissue sarcomas (STSs) grade is important for treatment decisions. To preoperatively distinguish low-grade (grades I and II) and high-grade (grade III) STSs, we developed and validated the performance of a magnetic resonance imaging (MRI)-based radiomics nomogram.Methods: Patients with an STS based on the French Federation of Cancer Centers Sarcoma Group grading system at two independent institutions were enrolled (training set, n = 109; external validation set, n = 71). The minimum redundancy maximum relevance method and least absolute shrinkage and selection operator logistic regression were used to process feature selection and radiomics signature development. Three radiomics signature models were constructed based on T1-weighted imaging (RS-T1 model) and fat-suppressed T2-weighted imaging sequences (RS-FST2 model) and their combination (RS-Combined model). Model performance (discrimination capability, calibration curve, and clinical usefulness) was evaluated in the external validation set. Results: The RS-T1 model, RS-FST2 model, and RS-Combined model achieved predictive abilities with area under the receiver operating characteristic curves (AUCs) of 0.645, 0.641, and 0.829, respectively, in the external validation set. The nomogram, incorporating significant clinical factors and the RS-Combined model, showed extremely high predictive ability in the training set and external validation set with AUCs of 0.916 (95% confidence interval, 0.866–0.966) and 0.879 (0.791–0.967), respectively. The nomogram achieved significant patient stratification.Conclusions: The proposed noninvasive MRI-based radiomics nomogram shows superior predictive performance in differentiating low-grade from high-grade STS.
Deflection Error Prediction and Minimization in 5-Axis Milling Operations of Thin-Walled Impeller Blades
Authors: Soori Mohsen , Asmael Mohammed
Published: October 2020

To enhance accuracy as well as efficiency in process of machining operations, the virtual machining systems are developed. Free from surfaces of sophisticated parts such as turbine blades, airfoils, impellers, and aircraft components are produced by using the 5-axis CNC machine tools which can be analyzed and developed by using virtual machining systems. The machining operations of thin walled structures such as impeller blades are with deflection errors due to cutting forces and cutting temperatures. The flexibility of thin walled impeller blades can cause machining defects such as overcut or undercut. So, the desired accuracy in the machined impeller blades can be achieved by decreasing the deflection error in the machining operations. To minimize the deflection of machined impeller blades, optimized machining parameters can be obtained. An application of virtual machining system in predicting and minimizing the deflection errors of 5-Axis CNC machining operations of impeller blades is presented in the study to increase accuracy and efficiency in process of part production. The finite element analysis is applied to obtain the deflection error in machined impeller blades. In order to minimize the deflection error of impeller blades in the machining operations, the optimization methodology based on the Genetic algorithm is applied. The impeller is machined by using the 5-axis CNC machine tool in order to validate the developed virtual machining system in the study. Then, the machined impeller is measured by using the CMM machines to obtain the deflection error. As a result, the deflection error of in machining operations of impeller by using 5-Axis CNC machine tools can be decreased in order to enhance accuracy and efficiency of part manufacturing.
FHL3 Contributes to EMT and Chemotherapy Resistance Through Inhibiting Ubiquitination of Slug and Activating TGFβ/Smad-Independent Pathways in Gastric Cancer
Authors: Cao Guodong , Li Pengping , Sun Qiang , Chen Sihan , Xu Xin , He Xiaobo , Wang Zhenyu , Chen Peng , Xiong Maoming , Chen Bo
Published: October 2020

Background: Gastric cancer presents high risk of metastasis and chemotherapy resistance. Hence, the mechanistic understanding of the tumor metastasis and chemotherapy resistance is quietly important.Methods: TCGA database and clinical samples are used for exploring the role of FHL3 in disease progression and prognosis. The roles of FHL3 in metastasis and chemotherapy resistance are explored in vitro and in vivo by siRNA or shRNA treatment. Finally, we explore the FHL3-mediated EMT and chemotherapy resistance.Results: mRNA and protein level of FHL3 is significantly up-regulated in gastric cancer tissues when compares with it in adjacent tissue. Higher expression level of FHL3 companies with worse overall survival in gastric cancer. OPH resistance cells show higher level of FHL3 and mesenchymal phenotype. Knockdown of FHL3 slightly inhibits the cell growth, while it obviously sensitizes the chemotherapy in vivo and in vitro. In addition, down-regulation of FHL3 decreases the mesenchymal markers, such as Slug, Snail, Twist1, and vimentin, while increases the epithelial marker E-cadherin. For mechanism study, FHL3 knockdown down-regulates the expression level or activity of MAPK/ERK pathway and TGFβ/PI3K/Akt/GSK3β-RNF146/ubiquitin pathway in OPH resistance cells. Mesenchymal phenotype cells hold higher level of MDR1, and the FHL3 knockdown reverts the MDR1 in this type cell. Conclusion: FHL3 is a risk of disease progression in gastric cancer. MAPK and PI3K pathways were activated when FHL3 induces EMT and drug resistance process, but the TGFβ/Smad -dependent pathway did not participate in the process. FHL3 competitively bond the ubiquitin complex (slug/GSK3β/RNF146) with slug, inhibit ubiquitination of Slug.
Difficulties of Prevention and Control Staff in COVID-19 Outbreak: A Cross-sectional Study Based on Five Provinces
Authors: Du Zhicheng , You Hua , Zhou Huan , Wang Xiaohui , Xu Jingdong , Li Yan , Li Shan , Ma Lina , Gu Jing , Hao Yuantao
Published: October 2020

Objectives: The aim of this study is to address the difficulties encountered by epidemic control staff in the early and middle stages of their efforts to combat COVID-19, compare the gaps among different types of institutions, and identify shortcomings in epidemic control. Methods: Using multi-stage sampling, a survey of primary (“primary-urban” and “primary-rural”) and non-primary (“CDC”) public health workers involved in the prevention and control of COVID-19 in five provinces, including Hubei, Guangdong, Sichuan, Jiangsu and Gansu, was conducted from 18 February to 1 March 2020 through a self-administered questionnaire.Results: A total of 9475 outbreak prevention and control workers were surveyed, of which 40.0% were from the primary-rural, 27.0% were from the primary-urban and 33.0% were CDC. Resources shortage was reported at 27.9%, with the primary-rural being the worst affected (OR=1.201, 95%CI: 1.073-1.345). Difficulties in data processing were reported at 31.5%, with no significant differences among institutions. Communication and coordination difficulties were reported at 29.8%, with the CDC being the most serious (the rural primary: OR=0.520, 95%CI: 0.446-0.606; the primary-urban: OR=0.533, 95%CI: 0.454-0.625). Work object difficulties were reported at 20.2%, with the primary-urban being the worst (OR=1.368, 95%CI: 1.199-1.560). Psychological distress was reported at 48.8%, with no significant differences among institutions.Conclusions: Psychological distress is the most serious problem in the prevention and control of COVID-19, and the resources shortage in primary-rural, communication and coordination difficulties in CDC, and difficulties in working with the target population in the primary-urban deserve attention. This study will provide a scientific basis for improving the national public health emergency management system, especially for reducing the urban-rural differences in emergency response capacity.
Using the RE-AIM Framework in Formative Evaluation of the EAT Family Style Multilevel Intervention
Authors: Dev Dipti A. , Padasas Irene , Hillburn Carly , Carraway-Stage Virginia , Dzewaltowski David A.
Published: October 2020

Background Ecological Approach To (EAT) Family Style is a 16-week responsive feeding Early Care and Education (ECE) intervention, utilizing a multilevel improvement system of 4 implementation strategies: (a) provision of a 7-lesson, on-line professional development training for administrators and teachers (b) administrative support; (c) performance monitoring, feedback, and assistance through follow-up coaching; and (d) use of incentives. The 7 lessons cover role modeling, peer modeling, sensory exploration, self-regulation, children serve themselves, praise and rewards, and family engagement, each relying on goal setting. The evidence-based practices and implementation system was delivered to ECE administrators and teachers completing one online lesson/week followed by a coaching session with a trained coach. EAT Family Style is guided by the self-determination theory. The objective of this study was to evaluate the EAT Family Style intervention through the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework.Methods Center-based ECE administrators (n=8) and teachers (n=17) caring for preschool (3-5 years) children and coaches (n=9) who participated in the EAT Family Style intervention were recruited. Semi-structured interviews were conducted, transcribed verbatim, and coded deductively by 3 coders using RE-AIM dimensions as a priori codes and placed into themes and sub-themes using thematic analysis. Results All participants perceived that EAT Family Style improved children’s nutritional and developmental outcomes and encouraged a positive mealtime environment (Effectiveness). Coaches and administrators reported EAT Family Style aligned with their professional goals and beliefs. Coaches found professional development incentives important, whereas administrators/teachers specifically valued in-service training credit hours (Adoption). Teachers reported successful implementation of EAT Family Style practices in the classroom. Administrators and coaches supported the teachers through administrative and coaching strategies (Implementation). All participants reported they intended to continue using the intervention. Administrators and teachers discussed incorporating EAT Family Style practices into handbook/school policy (Maintenance).Conclusion(s) EAT Family Style was viewed as feasible by participants. Its 4-pronged implementation strategy has the potential to improve the uptake of evidence-informed feeding practices in ECEs.
Pre-peritoneal Pelvic Pack with External Fixator versus Pelvic Pack Alone for Hemodynamically Unstable Patients with Pelvic Fracture; a Historical Cohort Study
Authors: Khoshmohabat Hadi , Paydar Shahram , Agah Mohammad Amin
Published: October 2020

BackgroundPelvic fracture is one of the most common cause of death in traumatic patients. This study was designed to compare the outcome, morbidity and complications of treatment with pre-peritoneal pelvic pack with external fixator against pelvic pack alone in traumatic pelvic fracture and unstable hemodynamic patients.MethodsIn a retrospective case control study, patients with pelvic fracture and unstable hemodynamic state who referred to emergency and surgery department from August 2018 to August 2019 were enrolled by census manner. In the control group, 25 patients treated just by a pre-peritoneal pack (PPP group), while in the case group, pre-peritoneal pack and external fixator was done as the procedure to control bleeding (PPP Plus fixator group) in 22 individuals. Two groups were compared for presence of thromboembolism, hospital stay, infection, BUN, creatinine, rate of blood transfusion and mortality. ResultsMean age of participants were 34.48 ± 13.79 in pelvic pack group, while it was 32.36±16.29 in PPP plus external fixator ones. The mean Injury Severity Score (ISS) was 23.12±9.85 in Pelvic Pack group, and 19.22±8.09 in PPP plus external fixator group. Acute kidney injury was reported in 6 (24%) individuals of PPP group, while its rate in PPP plus fixator group was 40.9%. Mortality rate was reported 32% and 4.5% in control and case groups, respectively. There was a significant difference between groups (p=0.017, LR=6.42). VTE was reported 12% and 4.5% in PPP group and PPP plus fixator ones, respectively.ConclusionIt was concluded that using external fixator with PPP can be a useful method for treatment of pelvic fracture that is unstable in hemodynamic situation. It is recommended to use biomarkers like lactate or others to determine the situation of patients as precise as possible.
Anxiety and Depression in Glaucoma Patients and its Correlations with Vision-related Quality of Life and Objective Visual Function Indices
Authors: Wu Na , Kong Xiangmei , Sun Xinghuai
Published: October 2020

Background: To investigate anxiety and depression in glaucoma patients and its correlations with vision-related quality of life (VR-QoL) and objective visual function indices.Methods: In this cross-sectional study, the Hospital Anxiety and Depression Scale (HADS) and the 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) questionnaires were administered to 446 Chinese glaucoma patients to assess their psychological disorders, namely anxiety and depression, and VR-QoL, respectively. Socio-demographic and clinical data were collected at the same time. Multivariate linear regression analysis was carried out to investigate the associations between VR-QoL, visual function indices and psychological disorders. Standardized partial regression analysis was used to identify the variable mostly indicative in evaluating psychological burdens. Results: The prevalence of anxiety and depression in Chinese glaucoma patients was 12.11% and 25.78%, respectively. Most of the subscales and the composite score of NEI VFQ-25 were negatively associated with each of anxiety and depression after adjusting for socio-demographic and clinical variables. For visual function indices, only the best corrected visual acuity of both eyes was correlated with anxiety after adjustment. Standardized partial regression analysis further showed VR-QoL but not the objective visual function indices mostly relevant to psychological disturbances. Conclusions: Anxiety and depression were common in Chinese glaucoma patients. Self-reported VR-QoL was beneficial in assessing glaucoma patients’ psychological disorders, while objective visual function indices provide little hint on it.
Atypical Neural Plasticity and Behavioral Effects of Trustworthiness Learning in High Vs. Low Borderline Personality Disorder Features: An Experimental Approach
Authors: Fertuck Eric , Fischer Stephanie , Melara Robert
Published: October 2020

Background: The ability to accurately decide who is trustworthy, and to, in the face of new information, adjust judgment of others’ trustworthiness accurately, flexibly, and efficiently is clinically impaired in Borderline Personality Disorder (BPD). Methods: A novel trust learning paradigm was administered to high (H-BPD) and low (L-BPD) in BPD features undergraduate participants. Neutral faces were paired with trust-relevant behaviors in each of four conditions: trustworthy, untrustworthy, mixed, and ambiguous. After training, participants rated faces on trustworthiness as electroencephalographic measures were recorded. Results: H-BPD rated neutral faces as significantly more untrustworthy than L-BPD at both time periods. Negative and ambiguous trustworthiness pairing conditions led to lower trustworthiness ratings, whereas trustworthy and mixed descriptors led to higher trustworthiness ratings. Training enhanced the amplitude of an early sensory ERP component (i.e., P1) for both groups. The slow wave ERP, an index of sustained attention, revealed greater focus after training to trustworthy descriptors in H-BPD and to untrustworthy descriptors in L-BPD. Conclusions: Social learning can modify an untrustworthiness bias in BPD at neural and behavioral levels. The results suggest that differential neural plasticity may account for the negative trustworthiness appraisal bias in BPD, and that interventions targeting frontal, attentional processes during trustworthiness learning may be a key mechanism of therapeutic change.