bluuebunny/crossref_metadata_2025 huggingface dataset:
Hak Waris Laki-Laki Nyentana dalam Perspektif Hukum Adat Waris Bali
Authors: Dewi Luh Anastasia Trisna , Sudantra I Ketut
Published: May 2022

Abstract

This study aims to examine the inheritance rights of men who marry nyentana to inheritance in their family of origin according to Balinese customary law. This research uses a normative research method, and utilizes a statutory and conceptual approach. The results of the study concluded that according to "Balinese inheritance law", a son who marries "nyentana" does not have inheritance rights in his original family because he is considered to have left the kedaton. However, after the establishment of the Pesamuhan Agung III Main Council of Pekraman Village (MUDP) Bali in 2010, boys who marry nyentana have limited space to inherit. However, the Decision of the Supreme Council III of the Pekraman Village Main Assembly (MUDP) does not automatically apply as Balinese customary law, before the values ??and principles on that Decision adheres into the awig-awig of traditional villages.

 

Abstrak

Penelitian ini bertujuan untuk mengkaji hak waris laki-laki yang kawin nyentana terhadap harta warisan di keluarga asalnya menurut hukum adat Bali. Penelitian ini menggunakan metode penelitian normatif, serta memanfaatkan pendekatan peraturan perundang-undangan dan pendekatan konseptual. Hasil penelitian menyimpulkan bahwa menurut “hukum adat waris Bali”, anak laki-laki yang kawin ”nyentana” tidak memiliki hak waris dalam keluarga asalnya karena ia dianggap ninggal kedaton.  Pasca ditetapkannya  Pesamuhan Agung III Majelis Utama Desa Pekraman (MUDP) Bali tahun 2010, anak laki-laki yang kawin nyentana memiliki ruang untuk mewaris yang sifatnya terbatas. Walaupun demikian, Keputusan Pesamuan Agung III Majelis Utama Desa Pekraman (MUDP) tidak serta merta berlaku sebagai hukum adat Bali, sebelum nilai-nilai dan prinsip-prinsip yang dalam ketentuan Keputusan a quo awig-awig desa adat.
Keautentikan Akta Risalah Rapat Umum Pemegang Saham (RUPS) Secara Elektronik Dalam Perspektif Cyber Notarylam Perspektif Cyber Notary
Authors: Satria Wibawa Pande Gde , Yogantara S. Pande
Published: May 2022

Abstract

The purpose of this study is to analyze the authenticity of the minutes of the General Meeting of Shareholders made electronically and the validity of the signature of the notary in the deed of the General Meeting of Shareholders made electronically. This study uses a normative legal research method by using a type of approach, namely, the statutory approach and the concept approach. The results of this study indicate that the GMS deed made electronically is an authentic deed if it uses the lex specialis derogate legi generali principle where the lex generalis is Article 16 paragraph (1) letter m of the Notary Jabata Law, while the lex specialis is Article 77 paragraph (1) in conjunction with the Elucidation of Article 77 paragraph (4) of the Limited Liability Company Law. The deed of the General Meeting of Shareholders can be ratified by a notary after being signed by the parties, and with the fulfillment of the provisions of Article 11 of the Information and Electronic Transaction Law, and the requirements specified in the provisions of Article 77 of the Limited Liability Company Law, as well as the ratification of the notary, the deed The General Meeting of Shareholders can be used as perfect evidence in court if in the future there are legal problems that occur between shareholders related to the deed of the General Meeting of Shareholders.

 

Abstrak

Tujuan dari penelitian ini adalah untuk menganalisa keautentikan akta risalah Rapat Umum Pemegang Saham yang dibuat secara elektronik dan keabsahan tandatangan notaris dalam akta Rapat Umum Pemegang Saham yang dibuat secara elektronik. Penelitian ini menggunakan metodepenelitian hukum normatif dengan menggunakan jenis pendekatan yaitu, pendekatan perundang-undang dan pendekatan konsep. Hasil dari penelitian ini menunjukan bahwa Akta RUPS yang dibuat secara elektronik adalah akta otentik apabila menggunakan asas lex specialis derogate legi generali dimana yang menjadi lex generalis–nya adalah Pasal 16 ayat (1) huruf m Undang-Undang Jabata Notaris, sedangkan lex specialis-nya adalah Pasal 77 ayat (1) jo Penjelasan Pasal 77 ayat (4) Undang-Undang Perseroan Terbatas. Akta Rapat Umum Pemegang Saham dapat disahkan oleh notaris setelah ditandatangani oleh para pihak, dan dengan terpenuhinya ketentuan pada Pasal 11 Undang-Undang Informasi dan Transaksi Elektronik, dan persyaratan-persyaratan yang ditentukan dalam ketentuan Pasal 77 Undang-Undang PT, serta pengesahan notaris maka akta Rapat Umum Pemegang Saham dapat dijadikan alat bukti yang sempurna di pengadilan apabila dikemudian hari terdapat permasalahan hukum yang terjadi antar pemegang saham terkait akta Rapat Umum Pemegang Saham tersebut.
The Mediating Effect of Knowledge Sharing on Interpersonal Trust and Job Satisfaction of Creative Industry in East Java
Authors: . Noerchoidah , Mochklas Mochamad , Indriyani Ratih , Arianto Bisma
Published: May 2022

The purpose of this study is to analyze the implication of multivariate relationship among interpersonal trust, knowledge sharing and job satisfaction in creative industry in East Java. This research uses 168 employees as respondents in order to test hypothesis. Data are processed using Partial Least Square (PLS) model. Empirical analysis shows that there are positive and significant relationships between interpersonal trust and knowledge sharing, knowledge sharing toward job satisfaction, also between interpersonal trust and job satisfaction. Furthermore, the result of this study shows that knowledge sharing acts positively as mediating variable between interpersonal trust and job satisfaction
International Quality Certification and Firms’ Innovation Performance in Bali, Lampung, and South Sulawesi
Authors: Harsanto Budi , Firmansyah Egi Arvian
Published: May 2022

Tujuan dari studi ini adalah untuk menganalisa perbedaan antara performa inovasi perusahaan yang memiliki dan tidak memiliki sertifikasi kualitas internasional di Bali, Lampung, dan Sulawesi Selatan. Ketiganya adalah tiga provinsi di luar pulau Jawa yang tercakup dalam Enterprise Survey gelombang terakhir di Indonesia (Bank Dunia, 2015). Ada 288 perusahaan di tiga provinsi tersebut yang menjadi partisipan dalam survey. Data hasil survey dianalisa menggunakan statistik deskriptif, uji chi-square (dengan Yates’ continuity correction dan Fisher’s Exact Test) serta uji Mann-Whitney U. Hasil analisa menunjukkan bahwa hanya 9,7 persen perusahaan memiliki sertifikasi kualitas internasional sebagai cerminan standar kualitas mereka. Uji chi-square memperlihatkan bahwa perbedaan signifikan tampak pada tipe inovasi proses dan organisasi, sementara inovasi produk tidak signifikan. Bila dihubungkan dengan kendala, uji Mann-Whitney mengungkapkan bahwa kendala-kendala yang dihadapi perusahaan dengan dan tanpa sertifikasi tidak signifikan secara statistik. Berbeda dengan studi terdahulu yang dominan menganalisa dampak sertifikasi terhadap performa operasional, penjualan, atau finansial, studi ini memberikan fokus kepada performa inovasi dengan data empiris unik berkonteks tiga provinsi di Indonesia yang berlokasi di luar pulau Jawa.
Does Risk Taking Behavior Drive MSME Innovation During Covid-19 Pandemic?
Authors: Memarista Gesti , Wijaya Olivia , Cahyadi Tiffany , Afandi Melissa
Published: May 2022

The study will contribute to the understanding of risk-taking behavior effect on the MSMEs innovation since the risk-taking behavior is the tendency of business owners for engaging in decisions that may have the potential to be dangerous to their business, especially for the family business to do some innovations nowadays, in the pandemic Covid-19 era. For the family business, the appropriate level of return that the business owner will obtain compensates their risk-taking behavior. These researchers used samples that consist of 307 MSMEs owners that categorized as the family business in Indonesia as the respondents by distributing online questionnaires. Furthermore, this paper also used control variables, such as the number of family members involved, generation level, founder-CEO duality, and business capital. This study used binary logistic regression for the analytical model. The results show that the business owner's risk-taking behavior, number of family members involved, generation level, founder-CEO duality, and business capital significantly influence MSMEs innovation in Indonesia.
DURASI MEJEJAITAN DENGAN KEJADIAN DE QUERVAIN SYNDROME PADA PEDAGANG BANTEN DI KOTA DENPASAR
Authors: Priutami Putu Savitri , Putra I Putu Yudi Pramana , Indrayani Agung Wiwiek , Adiatmika I Putu Gede
Published: May 2022

Pendahuluan: Pedagang banten merupakan salah satu pekerjaan yang memiliki risiko untuk mengalami gangguan muskuloskeletal. Hal ini disebabkan oleh aktivitas mejejaitan yakni kegiatan memotong dan merangkai janur menjadi banten yang akan digunakan untuk upacara agama Hindu di Bali. Aktivitas mejejaitan yang dilakukan pedagang banten dalam jangka panjang dan repetitif, akan menyebabkan gangguan muskuloskeletal salah satunya de quervain syndrome, yaitu merupakan peradangan pada selaput tendon (tenosynovitis) otot abductor pollicis longus dan extensor pollicis brevis sehingga menyebabkan nyeri pada ibu jari. Banyak faktor yang mempengaruhi terjadinya de quervain syndrome, salah satu faktor pencetusnya adalah durasi kerja. Penelitian ini bertujuan untuk mengetahui hubungan durasi mejejaitan terhadap risiko terjadinya de quervain syndrome pada pedagang banten di Denpasar.

Metode: Penelitian berlangsung dari bulan Januari – Maret 2021 dengan menggunakan metode penelitian observasional analitik dan desain cross-sectional analitik. Pengambilan sampel dengan teknik accidental sampling. Responden penelitian berjumlah 90 orang. Variabel dependen yang diukur yakni de quervain syndrome menggunakan Tes WHAT (Wrist Hyperflexion and Abduction Thumb) dan interpretasi nyeri berupa Numerical Rating Scale (NRS).

Hasil: Variabel independen yang diukur yakni durasi mejejaitan berdasarkan hasil wawancara. Berdasarkan hasil uji hipotesis melalui uji chi-square, didapatkan p = 0,016 (p<0,05).

Simpulan: Terdapat hubungan antara durasi mejejaitan yang signifikan dengan risiko terjadinya de quervain syndrome pada pedagang banten di Denpasar.

 

Kata Kunci: de quervain syndrome, mejejaitan, cedera berulang, tes WHAT, pedagang banten
TIGHTNESS OTOT UPPER TRAPEZIUS DENGAN KUALITAS TIDUR PADA PEKERJA KANTOR
Authors: Dewi Ni Luh Ratih Rosita , Putra I Putu Yudi Pramana , Primayanti I Dewa Ayu Inten Dwi , Kinandana Gede Parta
Published: May 2022

Pendahuluan: Pekerja kantor merupakan pekerjaan yang banyak menghabiskan waktunya bekerja secara statis dengan satu posisi. Bekerja dengan satu posisi dan duduk yang tidak ergonomis akan menyebabkan terjadinya nyeri pada leher dan salah satu otot yang paling sering mengalami nyeri yaitu otot upper trapezius. Rasa nyeri dan ketidaknyamanan yang ditimbulkan kemudian menjadi penyebab terjadinya gangguan tidur. Tujuan penelitian ini untuk membuktikan bahwa terdapat hubungan antara tigthness otot upper trapezius dengan kualitas tidur pada pekerja kantor di Denpasar.

Metode: Penelitian ini merupakan desain penelitian observasional analitik dengan desain studi cross-sectional. Penelitian ini menggunakan sebanyak 62 sample, dengan teknik pengambilan sampel yaitu consecutive sampling. Pada penelitian ini menggunakan variabel dependen adalah kualitas tidur yang diukur menggunakan kuisioner Pittsburgh Sleep Quality Index (PSQI), variabel independen adalah tightness otot upper trapezius yang diukur menggunakan Neck Disability Indeks (NDI), Goniometer, dan pemeriksaan length otot upper trapezius oleh fisioterapis. Variabel kontrol dalam penelitian ini yaitu pekerja kantor, usia, , Indeks Massa Tubuh (IMT), stress, penggunaan bantal saat tidur, dan lingkungan tempat tidur.

Hasil: Teknik analisis data menggunakan analisis bivariat dengan uji Chi-squre. Diperoleh nilai p= 0,030 pada uji chi-square NDI dengan Kualitas Tidur dan nilai p= 0,005 pada uji chi-square Keterbatasan ROM dengan kualitas tidur, dimana nilai p<0,05.

Simpulan: Dapat disimpulkan bahwa terdapat hubungan antara Tightness Otot Upper Trapezius dengan Kualitas Tidur pada Pekerja Kantor di Denpasar.

 

Kata Kunci: pekerja kantor, musculoskeletal disorder, kualitas tidur
Community Legal Awareness and Customary Sanction to Prevent Littering: How Penglipuran Village in Bali Makes Efforts?”
Authors: Putra Ida Bagus Sudarma
Published: May 2022

Penglipuran is a customary village in Bali that traditionally imposes a customary sanction for villagers who litter waste in the territory of the village in the form of holding a prayascita ceremony. This article aims to analyze the existence of prayascita customary sanctions in Penglipuran Village, the efforts to overcome littering in the village territory, and the implications of such sanctions on the legal awareness of the community. This paper combines a religious based-research in social-humanities and empirical juridical research that analyzes data and legal sources in descriptive, qualitative, and systematic methods. This research revealed that prayascita customary sanction is imposed on anyone who is decided guilty for littering in a village meeting, entails that he/she has to hold a prayascita ceremony that takes place in the village’s catus pata (crossroad). The efforts of Penglipuran Village to tackle littering problems are overseeing and maintaining the sanctity, sustainability, cleanliness, and orderliness of the area of ??the village. The programs and facilities that are implemented to control littering practice in this article can be divided into preventive and repressive measures. In terms of legal awareness, the village community has generally obeyed the customary rules. It is proven by the absence of people who have been imposed prayascita customary sanctions. It may be assessed that village members have a high community legal awareness to sort waste and put it in the rubbish bin. Therefore, the sanction to hold a prayascita ceremony has never happened until now. This indicates that a clean living culture has been well internalized by the community.
Job Creation Law and Foreign Direct Investment in Tourism in Indonesia: Is It Better than Before?
Authors: Widiatedja I Gusti Ngurah Parikesit , Suyatna I Nyoman
Published: May 2022

Foreign direct investment plays a critical role in a host country's economic development. Tourism, with its distinct character as a service business, is one of the most appealing investment industries. It has made a substantial contribution to the creation of jobs, tax revenue, and domestic value-added. The existence of domestic laws and regulations is critical in determining the extent to which a country's performance in getting benefits from investment can be maximized while reducing the negative impact. This article is aimed to examine whether the newly-enacted Job Creation Law provides a better arrangement on foreign direct investment in tourism compared to the previous laws and regulations. This article employs a normative approach by analyzing relevant laws and regulations concerning foreign direct investment in tourism in Indonesia. By looking at aspects on the choice of business fields, the issuance of business permit, land ownership, and labour, this article contends that Job Creation Law fails to provide integrated and comprehensive arrangements on the existence of foreign direct investment in tourism.
Peaceful Utilization of Transboundary Reservoir in Continental Shelf of Ambalat
Authors: Kharismawan Gede Khrisna , Eka Wisanjaya I Gede Pasek
Published: May 2022

Maritime boundaries between Indonesia and Malaysia in Ambalat have not been settled yet. This block is located on a continental shelf that is rich in transboundary reservoirs of hydrocarbons such as oil and gas. Malaysia as a coastal state wants to apply archipelagic state’s boundary, whereas Indonesia as an archipelagic state has applied for an extension of its continental shelf to the United Nations. Therefore, there is still unsettling business to be done in this area to fully utilize transboundary reservoirs in peace. This article aims to seek for way of solving the recurring conflict and utilizing transboundary reservoir in peaceful manner. This article is formulated using normative legal research based on statute, case, and conceptual approaches. This article concludes that differences between states on setting its boundaries is based on interpretation and is driven by economic value of resources, while there is opportunity to peacefully utilize transboundary reservoir by means of joint development based on international practices.
TÜRKİYE DÖVİZ PİYASASI ETKİNLİĞİNİN TEST EDİLMESİ
Authors: GÜNEŞ Hidayet
Published: May 2022

Etkin Piyasa Hipotezi, piyasadaki tüm bilgilerin varlık fiyatı içerisine dâhil olduğunu öne sürdüğü için bu bilgileri kullanarak ortalama piyasa getirisi üzerinde bir kazanç elde edilemeyeceğini belirtmektedir. Ancak piyasada uzun hafıza varlığının tespit edilmesi durumunda, bu durum ortadan kalkmaktadır. Çalışma, Türk lirasının 5 yabancı para birimi ile olan ikili uzun hafıza ilişkisini araştırmak için yapılmıştır. Getiride, Ruble / TL döviz kuru hariç tüm döviz kurlarında uzun hafıza olduğu tespit edilmiştir. Volatilitede, tüm döviz kurları için uzun hafıza varlığı bulunmuştur. Hem getiride hem de volatilitede, USD/ TL ve Yuan / TL döviz kurlarının uzun hafıza özelliği sergilediği belirlenmiştir.
Penerapan Algoritma Apriori Pada Transaksi Penjualan Untuk Rekomendasi Menu Makanan Dan Minuman
Authors: Merliani Nanda Nurisya , Khoerida Nur Isnaeni , Widiawati Neta Tri , Triana Latifah Adi , Subarkah Pungkas
Published: May 2022

Semakin pesatnya pertumbuhan bisnis bidang kuliner, membuat persaingan bisnis dibidang ini juga semakin ketat. Warung tenda atau yang biasanya disebut warten banyak menyajikan menu dan minuman, namun perlunya pelaku bisnis berusaha menghasilkan inovasi produk demi memberikan pelayanan memuaskan kepada pelanggan. Pada kondisi tersebut dibutuhkan sebuah teknik pengolahan data untuk mengetahui rekomendasi menu pada Warung Tenda. Metode analisis yang digunakan adalah teknik data mining dengan algoritma Apriori, dimana algoritma ini untuk mennetukan himpunan data yang paling sering muncul (frequent itemset). Hasil dari penelitian didapatkan bahwa Nilai Support dan Confidence tertinggi ialah Es Teh Manis dan Mendoan dengan nilai Support 50% dan Confidence 76%. Hal ini dapat menjadi rekomendasi kombinasi menu dari data yang telah dikumpulkan dan diterapkan algoritma apriori sehingga diharapkan dapat digunakan untuk evaluasi pelayanan serta mampu meningkatkan kepuasaan pelanggan agar Warung tenda dapat berkembang lebih pesat.
War and politics. The 2022 Russian invasion of Ukraine and refugee crisis on the eastern EU border from the perspective of border studies
Authors: Opioła Wojciech , Czepil Bartosz , Dębicki Marcin , Ganowicz Ewa , Kajta Justyna , Kovály Katalin , Moll Łukasz , Niedźwiecka-Iwańczak Natalia , Opiłowska Elżbieta , Pidgrushniy Grigorii
Published: May 2022

Since February 24, 2022, we have been witnessing the next stage of what began in the 2014 Russo-Ukrainian War: a full-scale military invasion of Ukraine. For the first time in the history of the European Union, the intensive armed conflict is now approaching the border of the EU and Schengen Zone. The consequences of war: the refugee crisis, humanitarian aid, and economic problems have affected EU countries both immediately and directly. While keeping in mind the human tragedy and the tragedy of Ukraine, we would like to address a few important questions from the perspective of regional and border scholars. From this perspective, the 2022 Russian invasion of Ukraine is another stage of the new political order in Europe, preceded by the war in Ukraine that started in 2014, the 2015 migration crisis, 2021 Belarus-EU border crisis, which altogether – from the perspective of the border studies – could be described as re-bordering and securitization of borderlands.

In this joint editorial, we address four main questions. Firstly, how we can interpret the Russian invasion in the wider, historical context, taking the frontier thesis as an explanatory category developed by Turner (1994). Secondly, the Ukrainian refugee crisis, in the context of the previous Belarusian-EU border crisis, is a multi-layered issue, where religion, gender, geopolitics, and rationales meet. Thirdly, apart from the military and political actions, war and refugee flux could be seen from the perspective of a grassroots movement of aid. Fourthly, the war in Ukraine brings uncertainty and questions about democracy and peace in Western Europe.
Employing an “aging paradox” to uncover effective measures for advancing productive longevity
Authors: Preuss Harry G. , Kaats Gilbert , Mrvichin Nate , Bagchi Debasis , Aruoma Okezie I.
Published: May 2022

Data gathered from healthy and non-diabetic volunteers who previously had participated in assorted clinical research trials, reveal that many medical risk factors primarily related to insulin resistance (IR) and the metabolic syndrome (MS) gradually intensify between ages 25 and 70 years. This phase here labeled “Continuum of risks” (CR) is a period whereby the metabolic changes that correlate with health situations adjust unfavorably but never exceed nor fall outside ranges that would diagnose established pathological diseases. The strengths of some of these risk factors unexpectedly reverted in an opposite and beneficial direction. This occurred somewhere beyond age 70 years. This phenomenon is defined as “Aging paradox” (AP). Because comparing data from the CR and AP periods did not reveal any significant differences in the glucose-insulin relationships with other components of MS, the beneficial happenings in AP were attributed to “Survivor bias.” The meaning behind this is that those volunteers possessing the more promising profile of risk factors can contribute to clinical studies, while participants with poorer profiles cannot take part as volunteers in later life due to medical debilities or even death. Health-wise, the average values of the following markers changed in a favorable direction when evaluated in the later AP period: Body weight, fat mass, fat free mass, levels of fasting blood glucose (FBG), triglycerides, HDL-cholesterol, and alanine aminotransferase enzyme. The lowering of FBG levels signifies the lessening of IR, the well accepted driving force behind MS. In contrast, total, LDL-, and non-HDL-cholesterol levels as well as systolic blood pressure essentially did not transform favorably over time. Health parameters associated with active survival should be at the center of attention in any developing schema to extend meaningful longevity. Thus, natural regimens involving nutrition, exercise, and dietary supplement usage exist to carry out necessary therapeutic measures to mitigate IR and its disabling components – thus potentially contributing to a longer healthier lifespan.
Implementation: Putting guidance into practice
Authors: Raj Raashi , McGuire Hugh , Pinilla-Dominguez Pilar
Published: May 2022

The implementation of guidance and advice into practice is a crucial step in ensuring that the uptake of guidelines’ recommendations that can contribute to improvements in health outcomes and equitable access to health services. The objective of this paper is to give an understanding of the common barriers to guideline implementation and the evidence-based implementation approach adopted by NICE to overcome these barriers.
Relationship of vitamin D deficiency with mammographic breast density and triple-negative breast cancer: A cross-sectional study
Authors: SINGH CHANDRA KUNWARI , THOMAS SHAJI , GOSWAMI BINITA , TOMER SHAILI , PATHANIA OM PRAKASH
Published: May 2022

Background

As breast epithelium is affected by vitamin D, it may have a direct effect on breast density and the risk of breast cancer. Our aim was to study the serum levels of vitamin D in patients with malignant and benign breast disease, and to study the association, if any, between vitamin D levels, mammographic breast density (MD) and molecular subtypes of breast cancer.

Methods

In this cross-sectional, observational study, we enrolled 162 consecutive adult women with benign and malignant breast masses subjected to mammography and core-needle biopsy. Serum levels of vitamin D were estimated and correlated with MD and with immunohistochemical subtyping of breast cancer.

Results

The mean vitamin D level in these 162 patients was 12.44 (5.88) ng/ml, with vitamin D deficiency seen in 98%. The mean (SD) vitamin D level in MD type 1 was 16.19 (4.62) ng/ml and it decreased to 7.54 (2.58) ng/ml in MD type 4. High MD was associated with significantly lower vitamin D levels. The mean vitamin D level in patients with benign breast disease (n=102) was 13.73 (5.68) ng/ml, while it was significantly lower in patients with breast cancer (n=60) at 10.26 (5.61) ng/ml. Among patients with breast cancer, the good prognosis luminal A molecular subtype had mean vitamin D level of 12.94 (6.16) ng/ml, whereas the poor prognosis triple-negative subtype had a significantly lower value of 7.68 (3.42) ng/ml.

Conclusion

Our study shows that vitamin D deficiency has a significant relationship with breast cancer (v. benign breast disease), high MD (showing increased breast cancer risk) and poor prognosis triple-negative breast cancer. Vitamin D deficiency could be an important, potentially modifiable, risk factor for the prevention of breast cancer in susceptible populations.
A WhatsApp-based introductory histopathology and cytology course for first-year pathology postgraduate students
Authors: DIWAN HIMANSHI , TANVEER NADEEM , DIXIT SONALI , KUMAR HARRESH
Published: May 2022

Background

The first-year pathology postgraduates can take a long time to learn the basic skills of microscopy, which can become a barrier to learning.

Methods

A WhatsApp group comprising all 14 postgraduate first-year students with one senior resident and one faculty as group administrators was formed. For the study, 50 routine cases (35 histopathology cases and 15 cytopathology cases) captured by using a smartphone camera and annotated using image-editing software, along with relevant descriptions and weblinks, were sent to the WhatsApp group. A pre- and post-test comprising 15 cases each was conducted and the results were compared by non-parametric Wilcoxon rank test. A feedback form about the effectiveness of this method of learning was circulated at the end of the study.

Results

The results of the post-test were better than the pre-test by the non-parametric Wilcoxon rank test. Both the active participants (>10 posts) and passive participants of the study group showed statistically significant improvement in the scores and posted a similar number of intellectually thought-provoking posts. The students’ responses to the questionnaire also indicated that they liked the new method of instruction.

Conclusion

This pilot study shows that smartphone-based learning methods can supplant the traditional methods of teaching for pathology postgraduates.
A Strategy to Enable Rapid Healing and Prevent Recurrence of Venous Ulcers
Authors: Yamamoto Kenji , Miwa Senri , Yamada Tomoyuki , Setozaki Shuji , Hamuro Mamoru , Kurokawa Shunji , Enomoto Sakae
Published: May 2022

Introduction. Venous ulcers are often intractable. Objective. The aim of this study was to retrospectively analyze the effectiveness of endovenous ablation, compression therapy, moist wound healing, and skin care in the management of venous ulcers. Materials and Methods. Twenty-eight consecutive patients (10 male, 18 female; mean age, 70.1 years) with Clinical-Etiology-Anatomy-Pathophysiology (CEAP) class C6 venous ulcer underwent endovenous ablation between December 2014 and August 2020. The main treatment strategies were radiofrequency ablation and varicectomy (including stab avulsion of incompetent perforating veins), use of compression therapy until complete healing was achieved, moist wound healing (washing the ulcer site and covering it with dressings twice daily), and skin care, taking into consideration the balance of the microbiome. Results. Active venous leg ulcers (CEAP class C6) were diagnosed in 36 patients at the first visit. In 7 of these patients, compression therapy and use of strategies to promote moist wound healing resulted in ulcer healing by the day of the planned surgery. One patient was unable to quit smoking and, therefore, could not undergo surgery. After excluding these 8 patients, the authors analyzed the data from 28 patients who underwent endovenous ablation. The mean surgical time was 38.9 minutes, and the mean number of stab avulsion incision sites was 9.7. All ulcers healed within a median of 55.5 days (range, 13–365 days). Ulcer healing was achieved by 1 year in all 28 patients (100%). No ulceration recurred as of the final follow-up (median, 24.5 months [range, 3–66 months]). Conclusions. Endovenous ablation, adequate varicectomy (stab avulsion [maximum number of sites in 1 patient, 43]), compression therapy, moist wound healing, and skin care are effective in treating and preventing recurrence of venous ulcers.
Analysis of quality of medical care in specialized ophthalmological clinic during pandemic of the novel coronavirus disease COVID-19
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution,  the Khabarovsk branch, Khabarovsk, Russian Federation, Baleva O.B. , Savchenko N.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution,  the Khabarovsk branch, Khabarovsk, Russian Federation, Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution,  the Khabarovsk branch, Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Egorov V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution,  the Khabarovsk branch, Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation
Published: May 2022

The purpose of article was to study quality of planned medical care in conditions of reprofiling around the clock inpatient care into outpatients care in the Khabarovsk branch of the Eye Microsurgery Federal State Institution (the Khabarovsk branch) during pandemic of the novel coronavirus disease COVID-19. Due to unfavorable epidemic situation in the world and high risk of transmission of infection to patients and medical staff, the Khabarovsk branch was re-profiled from around the clock inpatient care into outpatients care. This form of specialized ophthalmic care has proven to be in high demand. It contributes to increasing the availability of planned specialized care. The percentage of complications from treatment performed predominantly in a day hospital (0.3% in 2021) does not exceed the number of complications from treatment performed in around the clock inpatient care before the COVID-19 pandemic. Practice has shown that in order to minimize the risks of complications during treatment in outpatients care hospital, a more thorough approach to patient preparation is required. Keywords: number of hospital beds, around the clock inpatient care, outpatients care, complications, re-profiling of hospital.
Assessment using Cytoflavin® in patients after endovitreal surgery for rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation, Egorov A.V. , Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Egorov V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation
Published: May 2022

Purpose. To assess the functional efficiency of the obtained results of endovitreal surgery in patients with rhegmatogenous retinal detachment (RRD) by using Cytoflavin in the postoperative rehabilitation. Material and methods. 108 people (108 eyes) after surgery for RRD. Patients were divided into 2 groups: the 1st – 60 people who received Cytoflavin on the background of standard therapy, and the 2nd – 48 people with postoperative treatment only with standard therapy. We used Laser Doppler fluometry (LDF): microcirculation index and microcirculation efficiency index were recorded. Using OCT angiography (OCT-A) area nonperfusion of foveal avascular zone, density in the superficial capillary plexuses and density in the deep capillary plexuses in the macular area were investigated. Results. The inclusion of Cytoflavin in the postoperative rehabilitation of patients with RRD increases the possibility of a favorable functional outcome of the operation, affects the positive dynamics in the state of the capillary plexus in the macula. In the aggregate of patients of the 1st group, the increase in visual acuity was 2 times higher than in patients of the 2nd group 6 months after surgery. Conclusion. The prescription of Cytoflavin in the postoperative treatment of patients underwent endovitreal surgery of RRD increases the functional outcome of the operation. Keywords: rhegmatogenous retinal detachment, chorioretinal microcirculation, Laser Doppler fluometry, optical coherence tomography angiography, Cytoflavin.
Macular edema with retinal vein occlusion
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation, Fil A.A. , Sorokin E.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation,   Far Eastern State Medical University, Khabarovsk, Russian Federation, Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation
Published: May 2022

This literature review analyzes current data on the mechanisms of macular edema formation against the background of retinal vein occlusions, morphometric features of the macular region and chorioretinal hemodynamics. The main reason for the decrease in visual functions in retinal vein occlusion is macular edema. The technical possibilities of lifetime evaluation of both retinal structures and hemodynamics in choroid and retinal vessels in macular edema against the background of retinal vein occlusions are considered. This provides ample opportunities for a comprehensive in-depth study of the features of the development and course of macular edema, which will further identify possible predictors of its formation and persistence. Keywords: retinal vein occlusions, macular edema, morphometric features, chorioretinal hemodynamics.
OCT angiography in the diagnosis of the initial manifestations of the neovascular process in central serous chorioretinopathy
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Orenburg branch,  Orenburg, Russian Federation, Chuprov A.D. , Pligina O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Orenburg branch,  Orenburg, Russian Federation
Published: May 2022

In the chronic form of central serous chorioretinopathy (CSC), such a complication as the development of a neovascular membrane occurs, which requires a fundamentally different therapeutic approach. In this case, the correct diagnosis is very important. Purpose. To determine the value of the method of optical coherence tomography with angiography mode (OCTA) in the detection of neovascular process in CSC. Material and methods. The data of 29 patients (34 eyes) with acute (16 eyes) and chronic (18 eyes) forms of CSC were analyzed; we assessed best corrected visual acuity (BCVA), perimetry – the presence of scotoma, the presence of exudative detachment of neuroepithelium and retinal pigment epithelium (RPE) the presence or absence of newly formed vessels in the area of RPE detachment, the thickness and total volume of the retina in the macula. Results. According to the results of examinations, BCVA averaged 0.7 ± 0.1, relative scotomas were detected in 10 cases, retinal thickness averaged 306±18 µm, retinal volume 7.18 ± 0.5 mm3. In the chronic form of CSC, neovascularization under RPE was detected in 4 cases, which amounted to 22.2 %. Conclusion. OCT angiography makes it possible to detect the neovascular membrane, which determines the choice of treatment for CSC. Keywords: central serous chorioretinopathy, neovascular membrane, OCT angiography.
Efficiency of using light neuro-visual stimulation in infants with delayed visual maturation
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation, Mazurina O.V.
Published: May 2022

Purpose. To study the effectiveness of neuro-visual light stimulation in infants with delayed visual maturation (DVM). Material and methods. The study involved 22 infants with DVM at the age of 2–3 months. In all children, the movements of the eyeballs were insufficiently coordinated; there were also no visual reflexes of tracking and stable fixation. All patients were divided into two groups – the main (12 people) and comparison (10 people). Children of both groups received neurotropic therapy. Additionally, patients of the main group were prescribed light therapy of fontanelles with the Bioptron device daily for 30 seconds in one session (15 seconds for each fontanel). The duration of the course was 15 days with a frequency of course treatment every 1–1.5 months until the desired therapeutic effect is obtained. Efficiency criteria: the rate of development of visual functions and behavioral reactions corresponding to the variant of the age norm. Results. After the first course of using the Bioptron device, 8 out of 12 children of the main group developed a tracking reaction, gaze fixation, and consistency in the movements of the eyeballs. In three children – only after the second course of light therapy, and in one child – after the third course of treatment. In the control group, two out of 10 children after 15 days from the start of neurotropic therapy developed eye movement coordination, a stable reaction to tracking objects, and stable gaze fixation; in the remaining 8 children, these reactions appeared only 5 months after the start of treatment. Conclusion. Neuro-visual light stimulation, as an addition to pharmaconeuroprotection, significantly reduces the time for the formation of normal visual functions in case of DVM. Keywords: neuro-visual light stimulation, delayed visual maturation, Bioptron.
Diagnosis and treatment of bacterial, chlamydial and adenoviral conjunctivitis
Authors:   Ufa Eye Research Institute of the Academy of Sciences of the Republic of Bashkortostan,  Ufa, Russian Federation, Babushkin A.E. , Shevchuk N.E. ,   Ufa Eye Research Institute of the Academy of Sciences of the Republic of Bashkortostan,  Ufa, Russian Federation
Published: May 2022

In the review article, based on the analysis of modern literature data and own long-term clinical experience, some practical issues of conjunctivitis are presented, which continue to be an urgent problem of modern ophthalmology. In particular, this paper presents modern methods of diagnosis and treatment of the most common conjunctivitis, namely, we are talking about bacterial, chlamydial and adenoviral lesions of the mucous membrane of the eye. At the same time, much attention is paid to antibiotic therapy of bacterial and chlamydial conjunctivitis, in which a special place is occupied by antibiotics- fluoroquinolones, which have a wide spectrum of action and are the first choice drugs for bacterial and chlamydial conjunctivitis, especially resistant to other antibiotics. Keywords: bacterial, chlamydial, adenoviral conjunctivitis, diagnosis, treatment.
The study of herpes virus infection in the development of acute optic neuritis of unknown etiology
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation, Povalyaeva D.A. , Egorov V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation,   Postgraduate Institute for Public Health Specialists, Khabarovsk, Russian Federation, Smoliakova G.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation,   Postgraduate Institute for Public Health Specialists, Khabarovsk, Russian Federation, Danilova L.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation,   Postgraduate Institute for Public Health Specialists, Khabarovsk, Russian Federation, Emanova L.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation, Zhaivoronok N.S. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation
Published: May 2022

Purpose. Study of the etiological significance of herpesvirus infection (HVI) in patients with acute optic neuritis (ON) of unknown etiology using clinical and laboratory monitoring. Material and methods. Clinical and laboratory studies were carried out over 10 years and were based on the results of etiological monitoring of 81 patients (85 eyes) with acute ON in the period from 2008 to 2018. Results. During a comprehensive examination of 81 patients with acute ON, various infectious pathogens were diagnosed in 75 people (95 %). HVI dominated in 87 % of cases. In the total population of examined patients with acute ON associated with HVI, herpes simplex virus-1 was more common, Epstein – Barr virus and cytomegalovirus were less common. Active current HVI in the general group of patients was diagnosed in 58 patients (84 %). At the same time, the predominance (80 %) of reactivation of chronic infection was noted, and even less often (4 %), primary acute BBVI was diagnosed. The remaining 11 patients (16 %) had chronic persistent BBVI. Conclusion. Based on the complex of serological markers in the reactions of enzyme immunoassay of blood serum, it was found that the frequency of herpes virus infection is 87 %. The results of the performed clinical and laboratory studies are of great practical importance for the verification of the etiological diagnosis and the choice of adequate etiopathogenetic therapy in patients with acute ON associated with HVI. Keywords: acute optic neuritis, herpes virus infection, laboratory monitoring, serological markers.
On question of prevention of capsular block after cataract phacoemulsification with implantation of posterior chamber IOL
Authors:   Ufa Eye Research Institute of the Academy of Sciences of the Republic of Bashkortostan, Ufa, Russian Federation, Orenburkina O.I. , Babushkin A.E. ,   Ufa Eye Research Institute of the Academy of Sciences of the Republic of Bashkortostan, Ufa, Russian Federation, Hanova G.F. ,   Ufa Eye Research Institute of the Academy of Sciences of the Republic of Bashkortostan, Ufa, Russian Federation
Published: May 2022

Purpose. Method for the formation of anterior capsulorhexis for the prevention of capsular block in cataract phacoemulsification with implantation of a posterior chamber IOL was suggested. Material and methods. 67 patients (67 eyes) were operated on, for whom capsulorhexis was performed according to the method proposed by the authors in the form of an ellipse with a large axis of 7.0–7.5 mm along the tunnel incision and a small axis of 4.0–5.0 mm. Results. We did not observe any complications during the operation, as well as in the early and late postoperative period (damage to the anterior capsulorhexis, capsule block, bullous keratopathy, etc.). Only 2 patients (3%) were diagnosed intraoperatively with posterior capsule fibrosis, which required posterior capsulorhexis, which was performed after IOL implantation. At the same time, it should be noted that capsulorhexis was technically easier to carry out, since access to the posterior capsule was increased due to the previously performed oval anterior capsulorhexis. It was noted that the proposed method of forming the anterior capsulorhexis facilitates the insertion of the working part of the chopper over the edge of the lens when using the core fracture technique, reduces the risk of damage to the lens capsules, ensures reliable fixation of the IOL in the capsule bag and increases access for carrying out the posterior capsulorhexis, if necessary. After the operation UCVA and BCVA showed statistically significant increase, as much as possible after a month, but the difference with the data at the hospital discharge is statistically unreliable. After 1 year, visual functions remained stable, IOP was normalized. Conclusion. The proposed method for the formation of anterior capsulorhexis in cataract phacoemulsification with implantation of a posterior chamber IOL reliably eliminates the possibility of a capsule block due to the formation of an oval shape of the capsule hole. In addition, during the operation, it facilitates the insertion of the working part of the chopper over the edge of the lens when using the core fracture technique, reduces the risk of damage to the lens capsules, ensures reliable fixation of the IOL in the capsule bag by preserving sufficient peripheral flaps of the anterior capsule, and also increases access for posterior capsulorhexis under the IOL, if necessary. Keywords: cataract phacoemulsification, posterior chamber IOL, capsule block, oval capsulorhexis.
Produktionsstrategien für Mehrzweckanlagen
Authors: Buxtorf Christoph F.
Published: May 2022

Multipurpose equipment is an important element in the portfolio in manufacturing of chemical specialties. As for every manufacturing strategy, this special case also has to be embedded in supply chain strategies and long-range business plans. Flexibility when focusing on the future
market needs in terms of the product life cycle and the chemistry is the most important element of the strategy. Creative leadership and operators are indispensable assets in all stages of the strategy.
Custom Manufacturing of Fine Chemicals in a cGMP Multipurpose Plant. An Opportunity for a Niche Player
Authors: Habegger Erich
Published: May 2022

A brief background of the (pharmaceutical) fine chemicals market is given. Based on the requirements of the market, the critical design parameters of a cGMP multipurpose plant are discussed. A model is presented which describes the relative influence of various key-cost factors on the
overall performance of the plant. The reference facility used in this study is the cGMP multipurpose plant which is currently being constructed at the Rohner site in Pratteln, Switzerland. The impact of selected technical parameters (reactor volume, campaign size, change-overtime, etc.)
on the performance of the plant is discussed. In view of a high labor cost situation (e.g. Switzerland), the relevance of the capital investment costs versus labor costs is investigated. A benchmark comparison is made with five different cGMP multipurpose plants which compares
the capital investment costs with the capacity.
Mehrzweckanlage: Eine Chance aus der Vielfalt mehr zu machen
Authors: Higel Jean-Marie
Published: May 2022

Ciba Specialty Chemicals (SWX:CIBN, NYSE: CSB) is an international key player with 7200 million SFr. sales in 1999. The process development of the Additives Division is based in Schweizerhalle (CH). To optimize the utilization of the pilot and small-scale plant, mathematical
design methods are applied.
Umsetzung der MPP Anforderungen im Anlagenbau
Authors: Wasescha Domenic
Published: May 2022

Designing and building a multipurpose plant requires a project management familiar with production technologies. A short summary of the current project environment is given and the resulting design philosophy explained. Using the cGMP-project at Rohner AG, examples of technical project
management are given. Emphasis is put on the early project phases as the key to successful project completion. A profile for a successful project manager is drafted.