bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease
Authors: Tian Mi , Li Xinyun , Li Jingyuan , Yang Jianmin , Zhang Cheng , Zhang Wencheng
Published: November 2020

Background: Liver plays an important role in lipid and glucose metabolism. Human antigen R (HuR) as an RNA regulator protein participates in many disease processes. Here, we investigated the specific role of HuR in hepatic steatosis and glucose metabolism.Methods: We investigated the level of HuR in liver from mice fed a normal chow diet (NCD) and high fat diet (HFD). Liver specific HuR knockout (HuRLKO) mice were generated and challenged with an HFD. Lipid levels and glucose metabolism index were examined. Results: HuR was downregulated in livers of HFD-fed mice. HuRLKO mice showed exacerbated HFD-induced hepatic steatosis but improved glucose tolerance as compared with controls. Consistently, HuR inhibited lipid accumulation in hepatocytes. Mechanically, HuR could bind to the mRNA of phosphatase and tensin homology deleted on chromosome 10 (PTEN), thus increasing their stability and translation. Finally, PTEN over-expression alleviated HFD-induced hepatic steatosis in HuRLKO mice.Conclusion: HuR modulates lipid and glucose metabolism through regulating PTEN expression.
Electronic Health Record-Based Genome-Wide Meta-Analysis and Mendelian Randomization Identify Metabolic and Phenotypic Consequences of Non-Alcoholic Fatty Liver Disease
Authors: Ghodsian Nooshin , Abner Erik , Gobeil Émilie , Taba Nele , St-Amand Alexis , Perrot Nicolas , Couture Christian , Mitchell Patricia , Bossé Yohan , Mathieu Patrick , Vohl Marie-Claude , Thériault Sébastien , Tchernof André , Esko Tõnu , Arsenault Benoit
Published: November 2020

Non-alcoholic fatty liver disease (NAFLD) has been associated with several blood biomarkers and chronic diseases. Whether these associations underlie causal effects remains to be determined. We aimed at identifying blood metabolites, blood proteins and human diseases that are causally impacted by the presence of NAFLD using Mendelian randomization. We created a NAFLD genetic instrument from NAFLD loci (MTARC1, GCKR, LPL, TRIB1, LMO3, FTO, TM6SF2, APOE and PNPLA3) identified in a new electronic health record based-GWAS meta-analysis (6715 cases and 682,748 controls). We found a potentially causal effect of NAFLD on tyrosine metabolism as well as on blood levels of eight proteins that could potentially represent new early biomarkers of NAFLD. Using results from the UK Biobank, FinnGen and the COVID-19 Host Genetics Initiative, we found that NAFLD was not causally associated with diseases outside the spectrum of liver diseases, suggesting that the resolution of NAFLD might not prevent other diseases.
Efficient ethylene purification by a robust ethane-trapping porous organic cage
Authors: Su Kongzhao , Wang Wenjing , Du Shunfu , Ji Chunqing , Yuan Daqiang
Published: November 2020

The removal of ethane (C2H6) from its analogous ethylene (C2H4) is of paramount importance in the petrochemical industry, but highly challenging due to their similar physicochemical properties. It is still remaining unexploited to utilize emerging porous organic cage (POC) materials for C2H4/C2H6 separation. Herein, we report the benchmark example of a truncated octahedral calix[4]resorcinarene-based POC adsorbent (CPOC-301), preferring to adsorb C2H6 than C2H4, and thus can be used as a robust absorbent to directly separate high-purity C2H4 from the C2H4/C2H6 mixture. Molecular modelling studies suggest the exceptional C2H6 selectivity is due to the suitable resorcin[4]arene cavities in CPOC-301, which form more multiple C–H···π hydrogen bonds with C2H6 than with C2H4 guests. This work provides a fresh avenue to utilize POC materials for highly selective separation of industrially important hydrocarbons.
A novel histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation
Authors: Niu Qingfeng , Song Zhe , Tang Kai , Chen Lixian , Ban Ting , Guo Zhongxin , Kim Chanhong , Zhang Heng , Duan Cheng-Guo , Zhang Huiming , Zhu Jian-Kang , Du Jiamu , Lang Zhaobo
Published: November 2020

In plants, RNA-directed DNA methylation (RdDM) is a well-known de novo DNA methylation pathway that involves two plant-specific RNA polymerases, Pol IV and Pol V. In this study, we discovered and characterized a new RdDM factor, RDM15. Through DNA methylome and genome wide siRNA analyses, we show that RDM15 is required for RdDM-dependent DNA methylation and siRNA accumulation at a subset of RdDM target loci. We show that RDM15 contributes to Pol V-dependent downstream siRNA accumulation, and interacts with NRPE3B, a subunit specific to Pol V. We also show that the C-terminal tudor domain of RDM15 specifically recognizes the histone 3 lysine 4 monomethylation (H3K4me1) mark. Structure analysis of RDM15 in complex with the H3K4me1 peptide showed that the RDM15 tudor domain specifically recognizes the monomethyllysine through an aromatic cage and a specific hydrogen bonding network; this chemical feature-based recognition mechanism differs from all previously reported lower methyllysine recognition mechanisms. RDM15 and H3K4me1 have similar genome-wide distribution patterns at RDM15-dependent RdDM target loci, establishing a link between H3K4me1 and RDM15-mediated RdDM in vivo. In summary, we have identified and characterized a histone H3K4me1-specific binding protein as a new RdDM component, and our structural analysis of RDM15 revealed a new type of chemical feature-based lower methyllysine recognition mechanism.
Immunogenicity and Safety of Concomitant Administration of 23-valent Pneumococcal Polysaccharide Vaccine and Trivalent Inactivated Influenza Vaccine in Adults Aged 50-70 Years
Authors: Liu Yuanbao , Hu Ran , Sun Xiang , Zhang Min , Tang Fenyang , Zhang Lei , Liu Xiaoqin , Shi Xuanwen , Ma Fubao , Luo Linyun , Wang Zhiguo , Chen Haiping
Published: November 2020

Background To explore the serological protective effect and to evaluate the safety after combined immunization with 23-valent pneumococcal polysaccharide vaccine and trivalent inactivated influenza vaccine in adults aged 50-70 years.Methods This trial was designed as a single-center, randomized, single-blind, and positive parallel control vaccination study. A total of 1,065 people aged 50-70 years old were observed in Zhenjiang city, Jiangsu Province. Three groups were established, namely, the combined vaccine group (366 people), the pneumonia vaccine group (363 people) and the influenza vaccine group (364 people). The subjects were randomly assigned to each group.Results A total of 1065 subjects were recruited. The noninferiority criterion of GMC ratios was met for all 7 pneumococcal serotypes after concomitant administration when compared with the administration of PPV23 alone. After concomitant administration, the noninferiority criterion of seroconversion rates was met for all inﬂuenza subtypes except the inﬂuenza H3 virus. The overall incidence of systemic adverse events was 6.67% (71/1065). The most frequently reported systemic adverse events were abnormal body temperature, muscle aches, nausea, and diarrhea. No statistically significant difference in systemic adverse events was found among the three groups.Conclusion The local and systemic response rates in the combination group, pneumonia group and influenza group were similar to those of many similar vaccines, suggesting that the vaccine has good clinical safety. Serological findings from the combination vaccine suggest that it should be encouraged in the future to increase vaccination rates for influenza and pneumonia.Trial Registration: ClinicalTrials.gov NCT02062281 February 13, 2014; Retrospectively registered.
Soil-transmitted Helminthiasis, Intestinal Protozoa and Clonorchiosis Infections in Southeast China: A Cross-sectional Study
Authors: Feng Yan , Yu Kegen , Chen Hualiang , Zhang Xuan , Lu Qiaoyi , Wang Xiaoxiao , Zhang Xueying , Yao Linong , Ruan Wei
Published: November 2020

Background: The large scale epidemiology of parasitic diseases in Zhejiang Province has not been investigated since the second national survey.Methods: We investigated the distribution of three types of parasitic diseases (i.g. soil-transmitted helminthiasis (STH), intestinal protozoa, and clonorchiosis) in Zhejiang province from late 2014 to 2015. Kato-Katz technique was used for STH and Clonorchis. Sinensis detection, transparent adhesive paper anal swab was used for pinworm detection, and iodine smear was for protozoa detection. Hookworm positive samples need to be cultured for identification of Ancylostmoma duodenale or Necator americanus. Results: 23,552 participants were included in this study (19,935 from rural area and 3,617 from urban area). The overall prevalence of any intestinal helminth infection was 1.800%. Seven species of helminth were found: A.duodenale, N.americanus, Trichuris trichiura, Ascaris lumbricoides, C. sinensis, Fasciolopsis buski and pinworm. The prevalence of STH infection was 1.711% (1.941% in rural area, 0.442% in urban area). Hookworm was the most prevalent infection (1.584%). Only 2.79% children were found for pinworm infection in rural area. 0.396% of the rural participants were infected protozoa, and Endolimax nana was the most prevalent (0.231%). C. Sinensis infected only one man. 89.135% of participants had good personal hygiene habits. The awareness of C. Sinensis was 24.467% and 45.963% in rural and in urban area, respectively. Conclusions: Comparing to the second national survey, the prevalence of STH and protozoa infections declined greatly and C. Sinensis infection was still rare in Zhejiang Province. However, hookworm, especially N.americanus was still a parasitic threat to population health. More health education about fertilization and farming habits should be provided in rural areas. The awareness of hookworm and C. Sinensis should be reinforced in both rural and urban areas.
Retrospective Analysis of the Influence of Closure of Mesenteric Defects on Complications During Laparoscopic Radical Resection of Right Colon Cancer
Authors: Du Zhouyuan , Wang Dianshi , Li Yuan , Hu Peng , Wu Chuanqing , Tao Kaixiong
Published: November 2020

Background: The influence of closure of mesenteric defects during laparoscopic radical resection of right colon cancer is still controversial.Methods: A total of 66 patients who were received laparoscopic radical resection of right colon cancer in our hospital were enrolled. The statistics of complications, included Postoperative Length of Stay, Exhaust time after surgery, Defecation time after surgery, Intraoperative blood loss, Length of incision, Length of operation, Lung infection, Abdominal infection, Anastomotic bleeding and Anastomotic leakage were examined.Results: The mesenteric defects were closed in 35 patients in Clousure group and not closed in 31 patients in Nonclosure group.The difference between two group included Total complication, Postoperative length of stay, Exhaust time after surgery, Defecation time after surgery, Length of operation, Lung infection, Abdominal infection, Anastomotic bleeding and Anastomotic leakage are not significant (p>0.05).Conclusion: Whether to close the mesenteric defects during laparoscopic radical resection of right colon cancer does not affect the rate of comlications.
Recycled volatiles determine fertility of porphyry deposits in collisional settings
Authors: Xu Bo , Hou Zeng-Qian , Griffin William L. , Lu Yongjun , Belousova Elena , Xu Ji-Feng , O'Reilly Suzanne Y.
Published: November 2020

An intensive study of the geochemical characteristics (including the volatile elements Cl and S) of apatite associated with porphyry deposits was undertaken to address the debate about the crust- or mantle-derivation of their copper and gold and to better understand the controls on the transport of metals in magmatic fluids in post-subduction settings. New geochemical data on apatite reveal parameters to discriminate mineralized porphyry systems across Iran and western China (Tibet and Yunnan), from coeval barren localities across this post-subduction metallogenic belt. Apatites in fertile porphyries have higher Cl and S concentrations (reflecting water-rich crystallization conditions) than those from coeval barren ones. Our new isotopic data also indicate these volatiles are likely derived from pre-enriched sub-continental lithospheric mantle, metasomatized by previous oceanic subduction. This study demonstrates that refertilization of suprasubduction lithospheric mantle during previous collision events is a prerequisite for forming post-subduction fertile porphyries, providing an evidence-based alternative to current ore-enrichment models.
Magnetic and Mesoporous Silica-Niobia Material as Modifier of Carbon Paste Electrode for p-Nitrophenol Electrochemical Determination
Authors: Tkachenko Oleg , da Rosa Danielle , Virgili Anike , Vasconcellos Marcos , Costa Tania , Arenas Leliz , Deon Monique , Benvenutti Edilson , de Menezes Eliana
Published: November 2020

In the present work, the sol-gel synthesis method was employed as strategy to obtain a magnetic and mesoporous silica-niobia material. The planned synthesis was based on the heterocondensation of niobium and silicon alkoxide precursors, in the presence of spherical magnetite particles. The resulting material presented interesting characteristics such as magnetism, large mesopores, in the range from 20 to 50 nm, and 68 m2 g−1 of surface area. These features allowed its use as modifier of carbon paste electrode for p-nitrophenol determination, since niobia has never been used in electrochemical sensors for the determination of nitrophenol compounds. By using differential pulse voltammetry technique, the electrode can be applied in a wide range of p-nitrophenol concentration, from 10 to 490 μmol L−1, with a limit of detection of 1.2 µmol L−1 and sensitivity up to 0.60 µA L µmol−1. The proposed electrode presented good sensitivity and selectivity and it was applied in real water samples.
The Implementation of Multiple Information Security Governance (ISG) Frameworks Strategy and Critical Success Factors in Indonesia’s Oil and Gas Industry: Case Study of PT X
Authors: Syahbuddin Bob Hardian , Afrida Wachid Yoga , Azzahro Fatimah , Hidayanto Achmad Nizar , Phusavat Kongkiti
Published: November 2020

Oil and gas industry are among the largest contributor to the Indonesia’s foreign exchange. Many believe that information technology will be major driver for economic wealth in the oil and gas Industry. However, implementing information technology to support corporate business process brings vast information security risks. There is a need of comprehensive information security governance that can comply to information security standards and regulations. This research is conducted to evaluate the use of multiple ISG frameworks for implementing information security governance in a multinational oil and gas company. In detail, we evaluate the effectiveness of such framework, assess its implementation maturity level, and identify the success and inhibiting factors for implementing ISG frameworks. This study shows that framework XYZ, as a multiple ISG framework, is effective to cover the controls of ISO 17799, COSO, and IT Risk Framework at once. Meanwhile, the observed case study indicated lack of compliancy of Framework XYZ followed by the invention of gap between current ISG implementation efforts and company visions. Lastly, several success and inhibiting factors are identified in the ISG framework implementation at PT X.
Los denticulados del yacimiento de Aizpea (Arive, Navarra): análisis de huellas de uso e interpretación funcional
Authors: Laborda Martínez María Amparo
Published: November 2020

En este trabajo se presentan los resultados del análisis funcional de las láminas y lascas con muescas o denticuladas, procedentes de los niveles del Mesolítico final y Neolítico antiguo del yacimiento de Aizpea (Arive, Navarra). Las microhuellas identificadas han permitido un preciso diagnóstico funcional para reconstruir la manera en que estos útiles fueron utilizados y el tipo de materias trabajadas. Este estudio ha revelado también la idoneidad de la aplicación de la metodología traceológica para inferir técnicas de transformación de distintos recursos. El trabajo de la madera y el hueso fueron las actividades realizadas con denticulados en Aizpea, obviamente relacionados con las estrategias de subsistencia de los grupos que ocuparon el abrigo en diferentes momentos entre el VIII y la primera mitad del VII milenio BP.
Sara4r: an R graphical user interface (GUI) to estimate watershed surface runoff applying the NRCS – curve number method
Authors: Hernández-Guzmán Rafael , Ruiz-Luna Arturo , Mendoza Eduardo
Published: November 2020

This paper introduces a graphical user interface (GUI) for the R software that allows the rainfall-runoff relationship to be calculated, using the curve number method. This GUI is a raster-tool whose outputs are runoff estimates calculated using land use/land cover and hydrologic soil group maps. The package allows the user to select among three different antecedent moisture conditions and includes modifications about the initial abstraction parameter. We tested this GUI with data derived from two watersheds in Mexico and the outputs were compared with those produced using a well-established GIS tool in a vector environment. The results produced by these two approaches were practically the same. The main advantages of our package are: (1) ‘Sara4r’ is faster than previous vector based tools; (2) it is easy to use, even for people with no previous experience using R; (3) the modular design allows the integration of new routines; and (4) it is free and open source.
Preparation and characterization of activated carbon developed from cotton cloth residue activated with phosphoric acid: adsorption of clofibric acid
Authors: Boudrahem N. , Aissani-Benissad F. , Boudrahem F. , Vial C. , Audonnet F. , Favier L.
Published: November 2020

Cotton cloth waste was used as a precursor to prepare activated carbon (ACCs) chemically activated with phosphoric acid. Adsorption behavior of prepared ACCs was correlated with physicochemical proprieties. The pore volume and BET surface of ACCs were determined by nitrogen adsorption isotherms and scanning electron microscopy was used to observe their surface morphologies. Fourier transform infrared (FTIR) spectroscopy analysis and pH point zero charge (pHPZC) were conducted to determine chemical properties. Under the optimal conditions: 50% impregnation ratio and thermal treatment under N2 flow at 600 °C during 60 min, the activated carbon prepared exhibits a high surface area 1,150 m2/g, 0.501 cm3/g micropore volume and an excellent adsorption performance. The adsorbed amount of clofibric acid is found to be 9.98 and 83 mg/g at, respectively, initial CA concentration of 10 and 100 mg/L at pH 3.0 and 20 °C. Diffusion and chemisorption are the steps controlling the adsorption of CA onto ACC 50% and the equilibrium data were well described by Freundlich isotherm.
Conformational Dynamics Analysis of MEK1 Using Hydrogen/Deuterium Exchange Mass Spectrometry
Authors: Yun Min Woo , Kim Kiae , Park Ji Young , Chung Ka Young
Published: November 2020

Background:

Activation of mitogen-activated protein kinases (MAPKs) is regulated by a phosphorylation cascade comprising three kinases, MAPK kinase kinase (MAP3K), MAPK kinase (MAP2K), and MAPK. MAP2K1 and
MAPK2K2, also known as MEK1 and MEK2, activate ERK1 and ERK2. The structure of the MAPK signaling cascade has
been studied, but high-resolution structural studies of MAP2Ks have often focused on kinase domains or docking sites, but
not on full-length proteins.

Objective:

To understand the conformational dynamics of MEK1.

Methods:

Full-length MEK1 was purified from Escherichia coli (BL21), and its conformational dynamics were analyzed
using hydrogen/deuterium exchange mass spectrometry (HDX-MS). The effects of ATP binding were examined by coincubating MEK1 and adenylyl-imidodiphosphate (AMP-PNP), a non-hydrolysable ATP analog.

Results:

MEK1 exhibited mixed EX1/EX2 HDX kinetics within the N-terminal tail through β1, αI, and the C-terminal helix. AMP-PNP binding was found to reduce conformational dynamics within the glycine-rich loop and regions near the DFG
motif, along with the activation lip.

Conclusion:

We report for the first time that MEK1 has regions that slowly change its folded and unfolded states (mixed
EX1/EX2 kinetics) and also report the conformational effects of ATP-binding to MEK1.
Diabetic Neuropathy Pain Management: A Global Challenge
Authors: Qureshi Zunaira , Ali Murtaza N.
Published: November 2020

Background:

Painful Diabetic Neuropathy (PDN) is a devastating condition affecting
one in three people with diabetes.

Introduction:

Keeping in mind the unceasingly escalating prevalence of diabetes mellitus worldwide,
the number of PDN patients is also expected to rise with a reduced quality of life in patients
and a staggering increase in healthcare costs. Despite relentless efforts and continuous research, the
commercially available medications for relieving diabetic neuropathy pain are only partially effective
with substantial side effects. This is, in part, due to our partial awareness of the underlying
complexities causing PDN. The pathogenesis of PDN remains elusive because of the difficulty in
obtaining damaged nerve samples and the absence of non-invasive methods to investigate the
pathogenesis at different stages of disease progression. The purpose of this review was to describe
pathogenesis, clinical manifestations and treatment options for PDN.

Methods:

The keywords relevant to the scope of this paper were put in electronic databases
(PubMed and Google Scholar) to fetch the relevant data. The data were then analyzed and
compiled.

Results:

A simplified overview of PDN for researchers new to the field has been provided in an attempt
to clarify common confusions. The changes in skin structure and functions in response to diabetes,
diabetic neuropathy and painful diabetic neuropathy are also discussed. The unavailability of
an efficacious pain reliever for PDN stresses on the need for identifying the microenvironmental
factors that are altered in PDN and manipulate them to tailor targeted theranostics.

Conclusion:

In the end, we proposed to consider the altered skin structure, function and microenvironmental
factors in the diabetic population for devising smart, targeted, stimuli-responsive treatment
options to attain maximum pain relief with minimum side effects.
Can Edible Insects Complement Conventional Livestock? The Desirability of Insect Nutrition for Food Security of a World Heritage Site and Biosphere Reserve
Authors: Hazarika Arup K. , Kalita Unmilan , Khanna Subhash
Published: November 2020

Background:

Insects have formed a part of the human diet since pre-historic times. Entomophagy
has garnered recent attention due to its increased role in food security as nutrient-rich alternatives
of conventional livestock.

Methods:

We have made an effort in this paper to study the edible insect composition of Manas National
Park, a UNESCO Natural World Heritage Site and Biosphere Reserve, located in the Indo-
Burma biodiversity hotspot of Southern Asia. Edible insect variety was determined through a
field reconnaissance while the nutrient composition (macronutrient and micronutrient) of each edible
insect species was computed through biochemical analyses with a view to explore the possibility
of promoting them as food/feed or as a base for nutritive products. We conducted nutrient profiling
using the Nutrient Value Score (NVS) model and UK Ofcom nutrient profiling (NP) model.

Results:

Hymenoptera and Orthoptera were found to be the dominant orders with 4 species each,
followed by Hemiptera with 3 species, Lepidoptera with 2 species, Mantodea, Blattodea and
Coleoptera with 1 species each. The nutrient analysis shows that insects have a rich nutrient composition
that is comparable with typical livestock.

Conclusion:

As realised during COVID-19, insects may prove to be an alternative, sustainable,
and cheaper sources of nutrients necessary for ensuring global food security.
Development, Validation, and Application of a High-Performance Liquid Chromatography Method for the Analysis of Dissolution Samples of Telmisartan and Rosuvastatin Calcium Double-Layer Formulation
Authors: Lee Sang-Ho , Lee Sang-Ho , Lee Jong-Hyuk , Kim Joo-Eun
Published: November 2020

Background:

Telmisartan and rosuvastatin calcium fixed-dose combination double-layer
tablet is used for hypertension and hyperlipidemia treatment. Owing to the critical problem in establishing
the specificity, precision, and accuracy of the USP analysis method and simultaneous analysis
method for both components, an analysis method that could be applied to researchers in the field is
urgently needed.

Objective:

To develop and validate a reversed phase-high-performance liquid chromatography method
for the quantitative analysis of dissolution samples of telmisartan and rosuvastatin calcium fixed-dose
combination double-layer tablets, as a hypertension and hyperlipidemia treatment.

Methods:

The developed analysis method was validated according to USP Category I requirements.
The validity of the quantitative assay of the dissolution test solution was determined based on the system
suitability, specificity, linearity, accuracy, precision, and solution stability of the assay for the components.

Results:

The developed method was selective and precise. The retention times of telmisartan and rosuvastatin
calcium was 8.1 min and 2.8 min, respectively, and system suitability was 0.217 and 0.17, respectively.
Both components showed linearity at 10–120% concentration. The accuracy and precision
were also within acceptable limits. The drugs in the dissolution samples were stable for a long time, no
interaction occurred between the excipients and active pharmaceutical ingredients, and no interference
was observed in the analysis.

Conclusion:

The quantitative analysis of the double-layered formulation of telmisartan and rosuvastatin
calcium was accurate, selective, and precise. Therefore, this method can be recommended for use in the
industrial quality control of telmisartan and rosuvastatin calcium formulations.
Prospects of Treating Tenosynovial Giant Cell Tumor through Pexidartinib: A Review
Authors: Alsayadi Yunes M.M.A. , Chawla Pooja A.
Published: November 2020

Background:

Tenosynovial giant cell tumor refers to a group of rarely occurring tumors that are
formed in the joints, which are characterized by pain, swelling, and limitation of movement of the joint. Surgery
is the main treatment strategy, but the tumor is likely to recur, especially in pigmented villonodular synovitis,
which is the diffuse-type giant cell tumor. Pexidartinib was approved in August 2019 by the Food and Drug
Administration (FDA) with a brand name TURALIO as the first systemic approved therapy for patients having
Tenosynovial Giant Cell Tumors (TGCT).

Objective:

In this review, different aspects pertaining to pexidartinib have been summarized, including the
pathophysiology of TGCT, chemistry, pharmacokinetics and pharmacodynamics of pexidartinib. Special
attention is given to various reported clinical trials of pexidartinib.

Methods:

A comprehensive literature search was conducted in the relevant databases to identify studies
published in this field during recent years.

Conclusion:

Pexidartinib acts by inhibiting the Colony-Stimulating Factor (CSF1)/CSF1 receptor pathway,
which leads to the inhibition of the cell lines proliferation and promotes the autophosphorylation process of the
ligand-induced CSF1 receptor. Pexidartinib emerged as a potential drug candidate for the treatment of TGCT.
Optimization of Scattering Parameters Through Numerical Investigation of One-Bit RF MEMS Switch Over Ku, K and Ka Band
Authors: Debnath Pampa , Mondal Ujjwal , Deyasi Arpan
Published: November 2020

Aim:

Computation of loss factors for one-bit RF MEMS switch over Ku, K and Ka-band for two different insulating substrates.

Objective:

Numerical investigation of return loss, insertion loss, isolation loss are computed under both actuated
and unactuated states for two different insulating substrates of the 1-bit RF MEMS switch, and
corresponding up and down-capacitances are obtained.

Methods:

The unique characteristics of a 1-bit RF MEMS switch of providing higher return loss under both
actuated and unactuated states and also of isolation loss with negligible insertion loss makes it as a
prime candidate for phase shifter application. This is presented in this manuscript with a keen focus
on improvement capability by changing transmission line width, and also of overlap area; where
dielectric constant of the substrate also plays a vital role.

Results:

The present work exhibits very low down-capacitance over the spectrum whereas considerable
amount of up-capacitance. Also when overall performance in terms of all loss parameters are
considered, switch provides very low insertion loss, good return loss under actuated state and standard
isolation loss.

Conclusion:

Reduction of transmission line width of about 33% improved the performance of the
switch by increasing isolation loss. Isolation loss of -40 dB is obtained at actuated condition in higher
microwave spectra for SiO2 at higher overlap area. Down capacitance of ~ 1dB is obtained which is
novel as compared with other published literature. Moreover, a better combination of both return loss,
isolation loss and insertion loss are reported in this present work compared with all other published data
so far.
Medicinal Research Progress of Natural Coumarin and its Derivatives
Authors: Khursheed Aadil , Jain Vikrant
Published: November 2020

Coumarins, a natural class of compounds, firstly isolated from Tonka beans, are found
in various medicinal herbs. This class of compounds has been reported of remarkable biological
and pharmacological applications, including antimicrobial, anticoagulants, anti-inflammatory as
well as cancer. Additionally, coumarins have revealed significant inhibition of different human cancers
viz bladder cancer, lung cancer, prostate cancer, ovarian cancer, colon cancer, breast cancer,
gastric cancer, leukemia, pancreatic cancer, etc. Therefore, the compilation of medicinal research
progress of natural coumarin and its derivatives will be beneficial for scientists and researchers
worldwide. The literature review of medicinal research progress of natural coumarin and its derivatives
was collected from various databases, including PubMed, Web of Science and Science Direct
from the year 1942 to date. The presented data on medicinal research progress of natural coumarin
and its derivatives provides a detailed review which could serve as a platform for future research.
The data presented the medicinal and biological activities of coumarin and its derivatives
like antimicrobial, anticoagulant, anti-inflammatory and anticancer in particular. This could be utilized
for future formulation and development of drugs and references based on coumarin and its
derivatives.
Software Reliability Growth Model with Rate of Change in Application Characteristics
Authors: Sharma Himanshu , Mehta Prarna , Tandon Abhishek
Published: November 2020

Background:

There has been continuous advancement in technologies for past few decades by incorporating new features in accordance to the market demand. The evolution of software projects/applications has intricated debugging process by generating numerous faults in it.

Objective:

In this study, an attempt is made to develop a software reliability growth model (SRGM) taking into account the software project/application’s characteristic such as complexity of code and testing environment. The simulation is based on previous fault data in order to foresee the future latent faults occurring in the system for a given time frame. This model not only forecast the number of faults but is an extended version of Kapur and Garg’s error removal phenomenon model incorporating factors that might have influence on the model.

Methods:

The performance of the model is validated using three data sets and finally compared with extant models, namely GO model and Yamada model to assess the proposed model’s efficiency.

Results::

The parameter estimations were significant and the proposed model performed better in comparison to the other two models.

Conclusion:

The proposed model is a contribution to the studies on the reliability of the project and can be extended in future by generalizing the results over various datasets and models.
Work-Family Balance and Supervisor Appraised Citizenship Behavior: The Link of Positive Affect
Authors: Carlson Dawn S. , Kacmar K. Michele , Grzywacz Joseph G. , Tepper Bennett , Whitten Dwayne
Published: November 2020

We use broaden and build theory (Fredrickson, 1998; 2001) to examine the relationship between work-family balance and organizational citizenship behaviors (OCB), and the extent to which these relationships are mediated by positive affect. Using a sample of 205 supervisor-subordinate dyads, we found that subordinate work-family balance predicted supervisors’ appraisals of subordinate’s engagement in both organization and individual OCB and was fully mediated by positive affect rated by the subordinate. Additionally, we found that these fully mediated relationships held when positive affect was measured by the supervisor.
Pernicious Performance Appraisals: A Critical Exercise
Authors: Stepanovich Paul L.
Published: November 2020

This article presents a pedagogical exercise where students can experience bias and chance in a performance appraisal process. Students in the role of Vice-presidents interview and make decisions regarding employment and pay for analysts. Student analysts are interviewed and either fired, promoted, or given pay increases based on the interview and the Vice-president’s information. Ultimately, it is revealed that there is no difference in true performance among analysts and that all decisions were based on bias and chance. The article provides an extensive literature review and teaching notes to support the problems with the administrative use of performance appraisals.
Information Sources for Trust Judgments in Managerial Relationships over Time: A Conceptual Analysis
Authors: Huang Yung-Kuei , Kwok Linchi
Published: November 2020

This article presents a conceptual analysis concerning which factors influencing interpersonal trust are subject to change in their informational utility over the course of a managerial relationship and which factors are more likely to remain salient. Based on existing literature, the authors examine the utility of social categories, trustors’ moods and emotions, third party influences, direct experiences, and shared perspectives as sources of trust-related data over time. A set of propositions are formulated to encourage future intellectual dialogues on trust development in vertical dyads and render a framework for empirical research in this area.
From the editor - May 2013
Authors: Young Angela
Published: November 2020

A letter from the editor.
The Acceptability and Efficacy of Electronic Data Collection in a Hospital Neurodevelopmental Clinic: Pilot Questionnaire Study
Authors: Patel Shrujna , Boulton Kelsie Ann , Redoblado-Hodge Marie Antoinette , Papanicolaou Angela , Barnett Diana , Bennett Beverley , Drevensek Suzi , Cramsie Jane , Ganesalingam Kalaichelvi , Ong Natalie , Rozsa Magdalen , Sutherland Rebecca , Williamsz Marcia , Pokorski Izabella , Song Yun Ju Christine , Silove Natalie , Guastella Adam John
Published: November 2020

Background

There is a growing need for cost-efficient and patient-centered approaches to support families in hospital- and community-based neurodevelopmental services. For such purposes, electronic data collection (EDC) may hold advantages over paper-based data collection. Such EDC approaches enable automated data collection for scoring and interpretation, saving time for clinicians and services and promoting more efficient service delivery.

Objective

This pilot study evaluated the efficacy of EDC for the Child Development Unit, a hospital-based diagnostic assessment clinic in the Sydney Children’s Hospital Network. Caregiver response rates and preference for EDC or paper-based methods were evaluated as well as the moderating role of demographic characteristics such as age, level of education, and ethnic background.

Methods

Families were sent either a paper-based questionnaire via post or an electronic mail link for completion before attending their first on-site clinic appointment for assessment. A total of 62 families were provided a paper version of the questionnaire, while 184 families were provided the online version of the same questionnaire.

Results

Completion rates of the questionnaire before the first appointment were significantly higher for EDC (164/184, 89.1%) in comparison to paper-based methods (24/62, 39%; P<.001). Within the EDC group, a vast majority of respondents indicated a preference for completing the questionnaire online (151/173, 87.3%), compared to paper completion (22/173, 12.7%; P<.001). Of the caregiver demographic characteristics, only the respondent’s level of education was associated with modality preference, such that those with a higher level of education reported a greater preference for EDC (P=.04).

Conclusions

These results show that EDC is feasible in hospital-based clinics and has the potential to offer substantial benefits in terms of centralized data collation, time and cost savings, efficiency of service, and resource allocation. The results of this study therefore support the continued use of electronic methods to improve family-centered care in clinical practices.
Citizen Responses to Government Restrictions in Switzerland During the COVID-19 Pandemic: Cross-Sectional Survey
Authors: Selby Kevin , Durand Marie-Anne , Gouveia Alexandre , Bosisio Francesca , Barazzetti Gaia , Hostettler Maxime , D'Acremont Valérie , Kaufmann Alain , von Plessen Christian
Published: November 2020

Background

The success of government-recommended mitigation measures during the COVID-19 pandemic depends largely on information uptake and implementation by individual citizens.

Objective

Our aim was to assess citizens’ knowledge and perceptions about COVID-19 recommendations in the Canton of Vaud, Switzerland.

Methods

A cross-sectional electronic survey with open and closed questions was disseminated by community-based partners prior to the relaxation of government restrictions. Outcomes included citizen knowledge (9-question measure) and worry about the virus, perception of government measures, and recommendations for improvements. Comparisons used linear regression, controlling for age, sex, education, and health literacy. Free-text answers were analyzed thematically.

Results

Of 807 people who accessed the survey, 684 (85%) completed all questions and 479 (60%) gave free-text recommendations. Overall, 75% were female, the mean age was 48 years, and 93% had high health literacy. Knowledge scores were high, with a median score of 8 out of 9. Mean levels of worry about the COVID-19 pandemic were higher in women than men (55/100 versus 44/100, P<.001), and in respondents with lower health literacy (57/100 versus 52/100, P=.03). Self-reported adherence to recommendations was high (85%) and increased with age and worry (both P<.001). Respondents rated their own adherence higher than others (85% versus 61%, P<.001). Moreover, 34% of respondents reported having self-quarantined; this rose to 52% for those aged ≥75 years. Those who had self-quarantined reported higher levels of fear. Nearly half (49%) of respondents felt the government response had been adequate, though younger age and higher levels of worry were associated with considering the response to be insufficient (both P<.001). Analysis of open-text answers revealed 4 major themes: access to and use of masks, gloves, and hand sanitizer; government messaging; lockdown and lockdown exit plan communication; and testing for COVID-19.

Conclusions

Knowledge, adherence, and satisfaction regarding government recommendations and response were high in this sample, but many desired greater access to personal protective equipment. Those with lower health literacy and those who have been in self-isolation reported greater concerns about the pandemic.
Mobile Apps as Audience-Centered Health Communication Platforms (Preprint)
Authors: Mackert Michael , Mandell Dorothy , Donovan Erin , Walker Lorraine , Henson-García Mike , Bouchacourt Lindsay
Published: November 2020

UNSTRUCTURED

Health communication campaigns often suffer from the shortcomings of a limited budget and limited reach, resulting in a limited impact. This paper suggests a shift of these campaigns to audience-centered communication platforms—particularly, apps on mobile phones. By using a common platform, multiple interventions and campaigns can combine resources and increase user engagement, resulting in a larger impact on health behavior. Given the widespread use of mobile phones, mobile apps can be an effective and efficient tool to provide health interventions. One such platform is Father’s Playbook, a mobile app designed to encourage men to be more involved during their partner’s pregnancy. Health campaigns and interventions looking to reach expectant fathers can use Father’s Playbook as a vehicle for their messages.
The Role of Strategic Prowess in Promoting High Compliance Management—A Sample of the Directors of The Iraqi Media Network
Authors: Mahmood Al Dulaimi Ahmad Jabbar , Younis Dr. Joumana , Abou Daya Dr. Hisham
Published: November 2020

The current research aims to identify the role of strategic prowess in strengthening the management of high commitment and the practice of the Iraqi media network of strategic ingenuity, and management of high commitment, and given the scarcity of studies that attempted to identify and recognize the nature of the relationships between the three research variables in their direct and indirect form in the Iraqi environment, in addition, the researcher’s attempt to study and address a real and realistic problem that directly affects the Iraqi media network.However, the research adopted the intentional stratified sampling method for a population of network managers 250 individuals. The researcher used the Thompson equation and Mascheran’s table for small samples and the size of the research sample was 160, And for this purpose, statistical tools and methods were utilized in analyzing the practical side of the search (arithmetic mean, standard deviation, Pearson correlation coefficient, simple and multiple regression methods, path analysis, Sobel test), and they were analyzed by the statistical program (SPSS V.26 & AMOS V 26), in addition to the descriptive and analytical approach through polling opinions and interviews, and it was the main tool in collecting data (the questionnaire). The theoretical part in an attempt to bridge the knowledge gap in explaining the variables.
Acciones y fundamentos del trabajo del Cuerpo Médico Escolar en el Uruguay (1907-1927). La construcción de la normalidad en los cuerpos en el magisterio
Authors: Sosa Fernanda
Published: November 2020

En este trabajo se analiza el funcionamiento del Cuerpo Médico Escolar (CME) en el Uruguay entre 1907 y 1927 y se sostiene que uno de los ámbitos de mayor influencia de sus acciones lo constituye la construcción de normalidad en los cuerpos de maestras, maestros y estudiantes magisteriales. La normalización es un concepto foucaultiano que refiere a la regulación de los cuerpos de los individuos (disciplinas) y de las poblaciones (biopolíticas) y que orientará el análisis de las acciones del CME, particularmente las desarrolladas con estudiantes magisteriales, concursantes para cargos docentes, y en el reconocimiento anual del estado sanitario del magisterio. Las acciones llevadas adelante por el CME se fundan en argumentos que provienen del higienismo, superpuestos con argumentos propios de la eugenesia. Para este trabajo se analizaron  reglamentaciones, sesiones e informes internos del Cuerpo Médico Escolar; artículos en Anales de Instrucción Primaria; Informes del CME en las Memorias de Instrucción Primaria y manuales de Anatomía, Fisiología e Higiene y de Economía Doméstica.
Utilizing Home Visits to Assess Social Determinants of Health During Family Medicine Residency
Authors: Cline Matthew , Pagels Patti , Gimpel Nora , Day Philip G.
Published: November 2020

Introduction: Home visits can improve quality of care and health outcomes and provide a unique opportunity to learn more about patients’ social context and assess patients’ various social determinants of health (SDH). The objectives of this study were to assess patient self-reported SDH, resident reflections on patient social status, the utility of a SDH survey during home visits, and resident comfort levels addressing patient SDH.
Methods: This was a mixed-methods pilot study utilizing patient self-reported data and open-ended reflection questions. Participants included adult patients aged more than 18 years from an urban safety-net clinic and family medicine residents who provide their care.
Results: We received forty-two surveys from 42 home visits. Most patients were female (61.9%) and African-American (45.2%), aged from 25 to 88 years (mean=60.24). Top patient-reported SDH include transportation, paying bills, and food insecurity. Common themes of resident responses included positive utility of the survey for assessing patient SDH; variation in comfort level when inquiring about patient SDH with positive influence from prior experience, assistance from colleagues, or prior good relations with patients; and expressed intention to include SDH assessment in future practice.
Conclusions: Residents recognized the value of assessing SDH during home visits and expressed intent to include it in future practice. Thorough assessment of patient SDH may help to craft a more robust and standardized system to prioritize patients who would most benefit from receiving home visits.
Sports and urban biodiversity: framework for achieving mutual benefits for nature and sports in cities
Authors: Wheeler M. , Grossinger R. , Ndayishimiye E. , Spotswood E. , Galt R.
Published: November 2020

Investing in nature and nature-based solutions is an important pathway to address the current ecological crisis. The loss of biodiversity, with around one million animal and plant species threatened with extinction, is putting at risk our economies, livelihoods, food security, health, and quality of life worldwide. Diverse and innovative measures are needed to reverse this decline and to restore healthy ecosystems. The magnitude of the challenge calls for the collaboration and contribution of all actors, including non-state actors, such as businesses, local authorities, civil society organisations, and individual citizens. Sports and urban biodiversity identifies the opportunities for sports federations and sport venue owners and operators to develop the seven elements essential for supporting nature in cities. Case studies from Europe, North America, Australia and South Africa capture the biodiversity actions taken by a variety of sports, from Olympic city planning to local projects at stadiums and practice facilities. These examples also reveal ways in which improvements to urban biodiversity elements can offer a better sporting experience for event participants and spectators.