bluuebunny/crossref_metadata_2025 huggingface dataset:
Allo-HSCT with TBI-based preconditioning for hepatosplenic T-cell lymphoma: two case reports and systematic review of literature
Authors: Chen Can , Yang Fan , Miu Peiwen , Shi Pengfei , Qian Shenxian
Published: January 2024

Hepatosplenic T cell lymphoma (HSTCL) is a particularly difficult-to-treat form of lymphoma, with many patients exhibiting primary resistance to chemotherapy. At present, no effective strategy for treating relapsed and refractory HSTCL has been established, with treatment being hampered by questions of how best to overcome chemoresistance to allow patients to attain more durable therapeutic benefits. While there have been marked advances in immunotherapy, allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains one of the primary approaches to curing HSTCL. Of patients who undergo immunochemotherapeutic treatment, many are resistant to conventional chemotherapeutic drugs yet remain sensitive to radiotherapy. We selected to employ a transplant pretreatment regimen consisting of total -body irradiation (TBI) and administered this regimen to two patients with HSTCL. Both patients achieved complete remission (CR) after transplantation, demonstrating extended periods without disease recurrence. We systematic reviewed previously published instances involving allo-HSCT in patients with HSTCL. We have found a total of 67 patients who have received allo-HSCT. In general, age<45 and the status of CR at HSCT may have a more favorable prognosis. Although the impact of TBI on prognosis was not found to be substantial, patients in the TBI group had higher 3-year overall survival (66.7% vs. 71.1%) and 5-year overall survival (58.4% vs. 71.1%) compared to patients in the non-TBI group. In addition, the relapse rate of the TBI group is approximately half that of the non-TBI group. This regimen is well tolerated and associated with low recurrence rates or complications, suggesting that it represents a viable pretreatment regimen for young HSTCL patients undergoing allogeneic HSCT.
Delta-8 gummies causing visual snow: a case report
Authors: Vaphiades Michael S.
Published: January 2024

A 26-year-old man developed visual snow syndrome (VSS) after consuming a little less than half of a delta-8 gummy (estimated at 4 mg of delta-8 tetrahydrocannabinol). Secondary VSS and hallucinogen-persisting perception disorder (HPPD) are discussed, and clinicians who evaluate patients with VS and VSS should ask about delta-8 gummies as an etiology of secondary VSS.
Associated factors of undernutrition in children with congenital heart disease: a cross-sectional study
Authors: Ruan Xiaorui , Ou Jun , Chen Yige , Diao Jingyi , Huang Peng , Song Xinli , Wei Jianhui , Sun Mengting , Shi Hongqiang , Li Liuxuan , Tang Jiapeng , Liu Hanjun , Qin Jiabi
Published: January 2024

Objective

To evaluate the prevalence and associated factors of undernutrition among children with congenital heart disease (CHD) who have not undergone surgeries in China.

Methods

This cross-sectional study included 734 CHD children along with their parents. The outcome of interest was undernutrition, including underweight, wasting, and stunting, defined as Z-scores (i.e., weight-for-age, weight-for-height, and height-for-age) ≤−2, according to the World Health Organization (WHO) growth standard. Exposures of interest, containing demographics, obstetric factors, maternal dietary factors, parents' life behaviors and habits, birth-related factors, cardiac-related factors, and preoperative factors, were analyzed using a multivariate logistic regression model to test their associations with undernutrition in CHD children.

Results

Overall, 36.1%, 29.7%, and 21.3% of cases were underweight, wasted, and stunted, respectively. Multivariate logistic regression indicated that underweight was associated with demographic factors (including parents' occupational status, family income, and maternal body mass index pre-pregnancy), low birth weight (OR = 4.60, 2.76–7.70), pulmonary hypertension (OR = 4.46, 3.09–6.43), and pneumonia (OR = 1.88, 1.28–2.76). Artificially-fed children were 2.34 (1.36–4.01) times more likely to be underweight. Occupied mothers (OR = 0.62, 0.44–0.88) and fathers (OR = 0.49, 0.26–0.92) served as protective factors, while mothers having gestational complications (OR = 1.56, 1.11–2.18) and exposed to noisy environment (OR = 1.64, 1.11–2.42) during this pregnancy, and pulmonary hypertension (OR = 3.21, 2.30–4.49) increased the chance of wasting in offspring. The odds of being stunted were greater in families with >2 children (OR = 1.88, 1.13–3.14), placental abruption during this pregnancy (OR = 25.15, 2.55–247.89), preterm births (OR = 1.84, 1.02–3.31), low birth weight (OR = 3.78, 2.16–6.62), pulmonary hypertension (OR = 2.35, 1.56–3.53) and pneumonia (OR = 1.93, 1.28–2.90). In subgroup analyses, the associations differed between patients with different feeding patterns (breastfeeding vs. non-breastfeeding), CHD classifications (cyanotic vs. acyanotic), and prematurity (preterm vs. non-preterm).

Conclusion

Undernutrition is common in preoperative CHD children. Familial demographics, maternal factors (including having gestational complications and exposure to noisy environment during pregnancy), and patient-related factors (encompassing preterm births, low birth weight, pulmonary hypertension, pneumonia, and feeding pattern) were found to contribute to undernutrition in CHD cases. However, associated factors among the three subgroups of distinct feeding patterns, CHD categorization, and prematurity exhibited varied outcomes, suggesting the necessity for targeted interventions.
Echocardiographic imaging and ventricular mechanics in pulsatile-flow LVAD pediatric patients: a systematic approach
Authors: Iacobelli R. , Di Molfetta A. , Amodeo A.
Published: January 2024

Echocardiography plays a crucial role in determining the eligibility for left ventricular assist device (LVAD) placement in patients experiencing advanced heart failure (HF) and in monitoring patient care after the implantation procedure. Because of its unique nature, pediatric population and pulsatile-flow LVADs used in pediatrics require specific skills so that pediatric echocardiographers must develop a systematic approach in order to image the patients pre and post LVAD implantation. Therefore, the purpose of this narrative review is to delineate a systematic echocardiographic approach for pediatric patients supported by pulsatile-flow LVADs.
Ethics of access to newly approved expensive medical treatments: multi-stakeholder dialogues in a publicly funded healthcare system
Authors: Bomhof Charlotte H. C. , Smids Jilles , Sybesma Sybren , Schermer Maartje , Bunnik Eline M.
Published: January 2024

Background: Due to rising healthcare expenditures, countries with publicly funded healthcare systems face challenges when providing newly approved expensive anti-cancer treatments to all eligible patients. In the Netherlands in 2015, the so-called Coverage Lock (CL), was introduced to help safeguard the sustainability of the healthcare system. Since then, newly approved treatments are no longer automatically reimbursed. Previous work has shown that as policies for access to CL treatments are lacking, patient access to non-reimbursed treatments is limited and variable, which raises ethical issues. The ethics of access were discussed in a series of multi-stakeholder dialogues in the Netherlands.

Methods: Three dialogues were held in early 2023 and included physicians, health insurers, hospital executives, policymakers, patients, citizens, and representatives of pharmaceutical companies, patient and professional organizations. In advance, participants had received an ‘argument scheme’ featuring three models: 1) access based on third-party payment (e.g., by pharmaceutical companies, health insurers or hospitals) 2) access based on out-of-pocket payments by patients 3) no access to CL treatments. During the dialogues, participants were asked to discuss the merits of the ethical arguments for and against these models together, and ultimately to weigh them. The discussions were audio-taped, transcribed, coded, and thematically analyzed.

Results: Generally, most stakeholders were in favour of allowing access–at least when treatments are clearly beneficial–to treatments in the CL. When discussing third-party payment, stakeholders favoured payment by pharmaceutical companies over payment by health insurers or hospitals, not wanting to usurp collective funds while cost-effectiveness assessments are still pending. Largely, stakeholders were not in favour of out-of-pocket payments, emphasizing solidarity and equal access as important pillars of the Dutch healthcare system. Recurrent themes included the conflict between individual and collective interests, shifting attitudes, withholding access as a means to put pressure on the system, and the importance of transparency about access to CL-treatments.

Conclusion: Policies for access to non-reimbursed treatments should address stakeholders’ concerns regarding transparency, equal access and solidarity, and loss of potential health benefits for patients. Multi-stakeholder dialogues are an important tool to help inform policy-making on access to newly approved (too) expensive treatments in countries facing challenges to the sustainability of healthcare systems.
Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study
Authors: Hussain Talib , Alafnan Ahmed , Almazni Ibrahim Abdullah , Helmi Nawal , Moin Afrasim , Baeissa Hanadi M. , Awadelkareem Amir Mahgoub , Elkhalifa AbdElmoneim O. , Bakhsh Tahani , Alzahrani Abdulrahman , Alghamdi Rashed Mohammed , Khalid Mohammad , Tiwari Rohit Kumar , Rizvi Syed Mohd Danish
Published: January 2024

At the molecular level, several developmental signaling pathways, such as Wnt/β-catenin, have been associated with the initiation and subsequent progression of prostate carcinomas. The present report elucidated the anti-cancerous attributes of an anthraquinone, aloe-emodin (AE), against androgen-independent human prostate cancer DU145 cells. The cytotoxicity profiling of AE showed that it exerted significant cytotoxic effects and increased lactose dehydrogenase levels in DU145 cells (p < 0.01 and p < 0.001). AE also induced considerable reactive oxygen species (ROS)-mediated oxidative stress, which escalated at higher AE concentrations of 20 and 25 μM. AE also efficiently instigated nuclear fragmentation and condensation concomitantly, followed by the activation of caspase-3 and -9 within DU145 cells. AE further reduced the viability of mitochondria with increased cytosolic cytochrome-c levels (p < 0.01 and p < 0.001) in DU145 cells. Importantly, AE exposure was also correlated with reduced Wnt2 and β-catenin mRNA levels along with their target genes, including cyclin D1 and c-myc. Furthermore, the molecular mechanism of AE was evaluated by performing molecular docking studies with Wnt2 and β-catenin. Evidently, AE exhibited good binding energy scores toward Wnt2 and β-catenin comparable with their respective standards, CCT036477 (Wnt2 inhibitor) and FH535 (β-catenin inhibitor). Thus, it may be considered that AE was competent in exerting anti-growth effects against DU145 androgen-independent prostate cancer cells plausibly by modulating the expression of Wnt/β-catenin signaling.
Gastrointestinal symptoms in patients with postural orthostatic tachycardia syndrome in relation to hemodynamic findings and immunological factors
Authors: Tufvesson Hanna , Hamrefors Viktor , Fedorowski Artur , Hansson Monika , Ohlsson Bodil
Published: January 2024

Gastrointestinal (GI) symptoms are common in postural orthostatic tachycardia syndrome (POTS). We aimed to explore the prevalence and severity of GI symptoms in POTS, and to investigate immunological factors, hemodynamic findings, and their possible association with GI symptoms in POTS. Forty-three patients (93% female, median age 30.6 (26.0–41.0) years), previously diagnosed with POTS and 74 healthy controls (78% female, median age 35.6 (28.8–41.7) years) were included. The participants completed a questionnaire including prevalence of GI symptoms, the irritable bowel syndrome severity scoring system (IBS-SSS), and visual analog scale for IBS (VAS-IBS). All POTS patients were previously examined by tilt test (2010–2021) and the vast majority with more recent active standing test (2017–2021), which included monitoring of heart rate (HR). ΔHR was calculated as difference between supine and upright position. Continuous variables from IBS-SSS and VAS-IBS were correlated to ΔHR. A microarray containing several autoantigens commonly targeted in systemic autoimmune disorders was used to assess prevalent autoantibodies in POTS and controls. Total IgE and S-tryptase were analyzed. GI symptoms were more prevalent and severe in POTS than in controls; nausea being the most prevalent (79.1% vs 4.9%, p < 0.001) and bloating and flatulence being the most severe (median 65 (25–88) vs 0 (0–14), p < 0.001). The median total IBS-SSS was 213 (135–319) in POTS vs 13 (0–54) in controls (p < 0.001). Total IBS-SSS was associated with low psychological wellbeing (r = 0.539, p < 0.001) in POTS. ΔHRmax correlated inversely with abdominal pain (r = −0.406, p = 0.007). After adjustments for psychological wellbeing, total IBS-SSS still associated inversely with ΔHR10min (β: 4.748; 95% CI: −9.172 to −0.324; p = 0.036). Similar results were seen with active standing test. The prevalence of autoantibodies did not differ between POTS and controls (29.4% vs 33.3%, p = 0.803). There was no association between GI symptoms and autoantibody status. Total IgE and tryptase were elevated in a few cases. This study confirms the high prevalence of GI symptoms in POTS. More pronounced tachycardia upon tilt table testing seems to be inversely correlated with severity of chronic GI symptoms in POTS. This study did not support the hypothesis that POTS is associated with immunological factors.
Design and experiments with a SLAM system for low-density canopy environments in greenhouses based on an improved Cartographer framework
Authors: Tan Haoran , Zhao Xueguan , Zhai Changyuan , Fu Hao , Chen Liping , Yang Minli
Published: January 2024

To address the problem that the low-density canopy of greenhouse crops affects the robustness and accuracy of simultaneous localization and mapping (SLAM) algorithms, a greenhouse map construction method for agricultural robots based on multiline LiDAR was investigated. Based on the Cartographer framework, this paper proposes a map construction and localization method based on spatial downsampling. Taking suspended tomato plants planted in greenhouses as the research object, an adaptive filtering point cloud projection (AF-PCP) SLAM algorithm was designed. Using a wheel odometer, 16-line LiDAR point cloud data based on adaptive vertical projections were linearly interpolated to construct a map and perform high-precision pose estimation in a greenhouse with a low-density canopy environment. Experiments were carried out in canopy environments with leaf area densities (LADs) of 2.945–5.301 m2/m3. The results showed that the AF-PCP SLAM algorithm increased the average mapping area of the crop rows by 155.7% compared with that of the Cartographer algorithm. The mean error and coefficient of variation of the crop row length were 0.019 m and 0.217%, respectively, which were 77.9% and 87.5% lower than those of the Cartographer algorithm. The average maximum void length was 0.124 m, which was 72.8% lower than that of the Cartographer algorithm. The localization experiments were carried out at speeds of 0.2 m/s, 0.4 m/s, and 0.6 m/s. The average relative localization errors at these speeds were respectively 0.026 m, 0.029 m, and 0.046 m, and the standard deviation was less than 0.06 m. Compared with that of the track deduction algorithm, the average localization error was reduced by 79.9% with the proposed algorithm. The results show that our proposed framework can map and localize robots with precision even in low-density canopy environments in greenhouses, demonstrating the satisfactory capability of the proposed approach and highlighting its promising applications in the autonomous navigation of agricultural robots.
What predicts instructional quality and commitments to teaching: self-efficacy, pedagogical knowledge or integration of the two?
Authors: Leijen Äli , Pedaste Margus , Baucal Aleksandar , Poom-Valickis Katrin , Lepp Liina
Published: January 2024

The aim of the paper is to identify different groups of in-service teachers based on their general pedagogical knowledge (GPK) and self-efficacy beliefs and to explore potential differences among these groups regarding their instructional quality and commitments to teaching. A sample of 161 in-service subject teachers (science, mathematics, or Estonian language) who taught in lower secondary schools in Estonia were included in the study. Data was collected with a GPK test and self-reported questionnaires on instructional quality and commitments to teaching in the context of an OECD Teacher Knowledge Survey. Based on the cluster analysis, three groups of in-service teachers were identified: “the over-confident” teachers with average self-efficacy and very low GPK, “the competent” teachers with high self-efficacy and GPK, and “the insecure” teachers with low self-efficacy and average GPK. These three types of teachers were different in terms of instructional quality and commitments to teaching. It seemed that teachers’ self-efficacy beliefs are more important than GPK for instructional quality; however, GPK is more important for teachers’ professional persistence illuminating their general sense of professional identity. Implications of these findings for teacher education and teacher retention will be discussed.
Bringing them back: using latent class analysis to re-engage college stop-outs
Authors: West Cassandra Lynn , Chen Qi , Boika Nduka
Published: January 2024

Half of the students who begin college do not complete a degree or certificate. The odds of completing a degree are decreased if a student has a low socio-economic status (SES), is the first in a family to attend college (first-generation), attends multiple institutions, stops out multiple times, reduces credit loads over time, performs poorly in major-specific coursework, has competing family obligations, and experiences financial difficulties. Stopping out of college does not always indicate that a student is no longer interested in pursuing an education; it can be an indication of a barrier, or several barriers faced. Institutions can benefit themselves and students by utilizing person-centered statistical methods to re-engage students they have lost, particularly those near the end of their degree plan. Using demographic, academic, and financial variables, this study applied latent class analysis (LCA) to explore subgroups of seniors who have stopped out of a public four-year Tier One Research intuition before graduating with a four-year degree. The findings indicated a six-class model was the best fitting model. Similar to previous research, academic and financial variables were key determinants of the latent classes. This paper demonstrates how the results of an LCA can assist institutions in the decisions around intervention strategies and resource allocations.
Integrating intrapreneurial self-capital, cultural intelligence, and gender in Chinese international education: pathways to flourishing
Authors: Dong Tianran , Li Xuetao
Published: January 2024

Background

This study investigates the complex interplay between Intrapreneurial Self Capital, Cultural Intelligence, and gender, and their collective influence on the flourishing of Chinese international students in foreign academic settings. As global interconnectivity intensifies, the increasing number of Chinese students seeking education abroad presents a unique opportunity to examine the psychological and sociocultural dynamics of this demographic.

Aim

Central to our investigation is the role of Cultural Intelligence, a crucial competency for navigating diverse environments, and Intrapreneurial Self Capital, a composite of psychological resources instrumental in educational and career success. The study also explores the mediating role of Cultural Intelligence in the relationship between Intrapreneurial Self Capital and student flourishing, and examines how gender moderates this dynamic.

Method

The research engaged 508 Chinese international students, utilizing a variety of social networks for participant recruitment. The survey, conducted via Qualtrics, focused on a diverse range of students across different educational levels and disciplines. A moderated mediation model was tested to examine the mediation effect of cultural intelligence on the relationship between intrapreneurial self-capital and flourishing, with gender serving as a moderating variable.

Results

Our findings reveal significant insights into how Intrapreneurial Self Capital and Cultural Intelligence contribute to the personal and professional development of Chinese international students. Overall, the results suggest that the impact of Intrapreneurial Self Capital on various cognitive qualities (Metacognitive Cultural Intelligence, Cognitive Cultural Intelligence, Motivational Cultural Intelligence and Behavioral Cultural Intelligence) is moderated by gender, highlighting the importance of considering gender differences in this context. Related to the prediction of Flourishing, the direct effect of Intrapreneurial Self Capital on flourishing is notably strong. However, the mediating roles of Metacognitive, Cognitive, and Behavioral aspects of Cultural Intelligence show different levels of influence.

Implications

The study underscores the need for educational institutions to adopt holistic approaches in fostering student well-being and success, accounting for the nuanced effects of cultural and gender dynamics. These results have significant implications for the development of targeted educational programs and training, aimed at enhancing the international educational experience for students and professionals.
The mediating role of impulsivity between sleep quality and suicidal ideation in adolescent population: a multicenter cross-sectional study in the northeastern Sichuan, China
Authors: Zhong Yunling , He Jinlong , Luo Jing , Zhao Jiayu , Cen Yu , Wu Yuhang , Song Yuqin , Lin Cen , Pan Lu , Luo Jiaming
Published: January 2024

Introduction

Suicidal ideation is a critical early stage in the progression towards suicidal be havior. Prior research has established links between sleep quality, impulsivity, and suicidal tendencies, yet the interaction among these factors has been less explored. This study aims to explore the mediating role of impulsivity in the relationship between sleep quality and suicidal ideation in adolescents.

Methods

Employing a cross-sectional study design, 6,974 questionnaires were distributed,including the Socio-demographic Characteristics Questionnaire, Barratt Impulsiveness Scale, the Positive and Negative Suicide Ideation Inventory,and the Pittsburgh Sleep Quality Index Scale. The participants were high school and middle school students from 33 schools in northeastern Sichuan, China, selected through random cluster sampling.

Results

Of these 6,786 questionnaires were analyzed. The participant distribution included 47.2% male and 52.8% female students, with 68.3% from junior schools and 31.7% from senior schools. The prevalence of suicidal ideation was found to be 13.6%. The analysis, which involved correlation analysis and the construction of a structural equation model, revealed that sleep quality had a significant positive effect on impulsivity (β:0.289,p < 0.05), and impulsivity, in turn, had a positive impact on suicidal ideation (β:0.355,p < 0.05).Moreover, sleep quality was directly linked to suicidal ideation (β:0.208,p < 0.05). Thus, sleep quality affects suicidal ideation both directly and indirectly through impulsivity.

Discussion

The results of this study suggest that both sleep quality and impulsivity are significant direct influencers of suicidal ideation among adolescents in the region studied, with impulsivity also playing an indirect role in the relationship between sleep quality and suicidal ideation.
The influence of lifestyle habits on levels of depression among rural middle school students in Northeastern China
Authors: Zhao JunCheng , Wang Xiaoyin , Xu Shiliang , Yan Wenjing , Wang Jingzhe , Wang Ende , Liu Tao , Hao Ming
Published: January 2024

Background

Depression rates among adolescents have risen dramatically over the past decade. Therefore, preventing depression among adolescents is particularly important. Differences in lifestyle habits may play a role in depression.

Purpose

This study aimed to explore the influence of living habits on depression levels among rural middle school students in Northeast China and to provide a theoretical basis for developing interventions to reduce depression levels in middle school students.

Methods

A total of 296 middle school students aged 13–15 years from Benxi City, Northeast China completed the anthropometric measurements, Physical Activity Scale-3 (PARS-3), and the Self-Rating Depression Scale (SDS). Their average screen time in the most recent week, parents' education level, and monthly family income were collected through a questionnaire.

Results

Females had higher depression scores than males (41.0 ± 6.9 vs. 37.9 ± 8.0). Physical activity (β = −0.38, t = −7.06, P < 0.01), family income (β = −0.20, t = −4.07, P < 0.01), screen time (β = 0.16, t = 3.34, P < 0.01), age (β = 0.15, t = 3.16, P < 0.01), sex (β = −0.13, t = −2.74, P < 0.01), and sleep quality (β = −0.08, t = −1.87, P < 0.01) are important factors related to depression levels.

Conclusion

The preliminary analysis results showed that among middle school students in rural Northeast China, the depression level of females was significantly higher than that of males. Poor quality sleep, low levels of physical activity, low household income, and long screen time were positively associated with depression. Therefore, strengthening physical activity, improving sleep quality, and reducing screen time are of clinical relevance in preventing and reducing depression.
Exploring refugees’ health care access in times of COVID-19: a quantitative study in the Lisbon region, Portugal
Authors: Portela Vanessa , Hamwi Sousan , Oliveira Martins Maria R.
Published: January 2024

Background

To address the health needs of refugees, health services must be culturally competent and facilitate this population’s access to health care, especially in a context prone to the amplification of social inequities, such as the COVID-19 pandemic. However, few quantitative studies exist in the European Union, and to the extent of our knowledge, there are no published quantitative studies exploring refugees’ access to health care during the pandemic in Portugal. The objective of this study is to describe the demographic and socioeconomic characteristics of refugees living in Lisbon and to explore their healthcare access patterns during the COVID-19 pandemic.

Methods

We conducted a cross-sectional, descriptive, and quantitative study from May to November 2022. Using Levesque’ s theory on health care access, we designed and applied a 38-item questionnaire through face-to-face interviews with refugees living in Lisbon for at least 12 months, and used descriptive statistics to characterize sociodemographic and healthcare access profiles during the pandemic.

Results

The mean age of the 36 recruited refugees was 35 years (SD = 10.24), the majority were male (56%), married (72%), had at least a secondary education (69%), were unemployed (77.8%), and had a median length of stay in Portugal of 17 months (IQR = 45). All were registered in a primary care center, and 94% used healthcare services during the pandemic. The majority never tested positive for the coronavirus (58%) and one out of the positive was admitted to hospital due to severe COVID-19. A total of 97% received COVID-19 vaccination, of which 69% had an incomplete schedule. A quarter of the participants did not have access to information about COVID-19 in a language they understood, and although 97% needed health care during the pandemic, more than half (63%) did not seek it because of structural and cultural barriers. Half of the respondents had difficulty getting medical advice by phone or email, and 39.4% could not afford a medical examination or treatment. Only 18.2% sought counseling services. A total of 58.8% of the participants felt like healthcare professionals did not always show respect towards their culture, and 64.7% reported that healthcare professionals did not always discuss treatment options with them.

Conclusion

This study’s findings highlight the need to endow inclusive communication, cultural competency, and patient involvement in health care, alongside improving the socioeconomic condition of refugees. Identified population characteristics and barriers to health care access by refugees in this study may inform future research on the health care needs of refugees in Portugal and ultimately assist in the devising of strategies to reduce inequalities in health care access.
Long-term air pollution and adverse meteorological factors might elevate the osteoporosis risk among adult Chinese
Authors: Sun Hong , Wan Yanan , Pan Xiaoqun , You Wanxi , Shen Jianxin , Lu Junhua , Zheng Gangfeng , Li Xinlin , Xing Xiaoxi , Zhang Yongqing
Published: January 2024

Objective

This study aims to investigate the relationship between exposure to air pollution and adverse meteorological factors, and the risk of osteoporosis.

Methods

We diagnosed osteoporosis by assessing bone mineral density through Dual-Energy X-ray absorptiometry in 2,361 participants from Jiangsu, China. Additionally, we conducted physical examinations, blood tests, and questionnaires. We evaluated pollution exposure levels using grid data, considering various lag periods (ranging from one to five years) based on participants’ addresses. We utilized logistic regression analysis, adjusted for temperature, humidity, and individual factors, to examine the connections between osteoporosis and seven air pollutants: PM₁, PM₂.₅, PM₁₀, SO₂, NO₂, CO, and O₃. We assessed the robustness of our study through two-pollutant models and distributed lag non-linear models (DLNM) and explored susceptibility using stratified analyses.

Results

In Jiangsu, China, the prevalence of osteoporosis among individuals aged 40 and above was found to be 15.1%. A consistent association was observed between osteoporosis and the five-year average exposure to most pollutants, including PM₂.₅, PM₁₀, CO, and O₃. The effects of PM₁₀ and CO remained stable even after adjusting for the presence of a second pollutant. However, the levels of PM₁ and PM₂.₅ were significantly influenced by O₃ levels. Individuals aged 60 and above, those with a BMI of 25 or higher, and males were found to be more susceptible to the effects of air pollution. Interestingly, males showed a significantly higher susceptibility to PM₁ and PM₂.₅ compared to females. This study provides valuable insights into the long-term effects of air pollution on osteoporosis risk among the adult population in China.

Conclusion

This study indicates a potential association between air pollutants and osteoporosis, particularly with long-term exposure. The risk of osteoporosis induced by air pollution is found to be higher in individuals aged 60 and above, those with a BMI greater than 25, and males. These findings underscore the need for further research and public health interventions to mitigate the impact of air pollution on bone health.
Can We Use Math to Design a Brighter Future?
Authors: Maskin Eric
Published: January 2024

Did you know that math can be used to help improve society? Well, believe it or not, it does so on a daily basis. Math not only helps us develop new technologies and engineering techniques, but also enables us to design modifications of our society that achieve desirable social goals—goals like reducing pollution and allocating resources to the people who value them the most. In this article, I will tell you about a branch of economics called mechanism design which helps economists do exactly that. Using mechanism design, we can reach important social goals that could not be attained without the modifications it points to. Keep reading to join me on a journey describing an economic theory that can help design a brighter future for us all.
Killer T Cells: Immune System Heroes
Authors: Doherty Peter , Segev Noa
Published: January 2024

This article is based on an interview between the two authors.

The human body is like a jungle, with trillions of fascinating things happening inside it every second, most of which occur without our awareness. In this article, we will zoom in on a very interesting part of this jungle of human-body activities—the immune system. The immune system protects the body from intruders with its experts in martial arts, called killer T cells. Killer T cells are responsible for eliminating virus-infected cells so that the virus cannot reproduce itself and spread throughout the body. Join me for an adventurous journey into the immune system, in which we will find out how killer T cells know which cells to attack and which to leave alone.
Can Grid Cells Help Us Understand The Brain?
Authors: Moser Edvard I. , Segev Noa
Published: January 2024

This article is based on an interview between the two authors.

Grid cells are special brain cells that play a key role in the brain’s navigation system. Research on these cells is one of the most interesting and rapidly advancing topics in brain science today. Much has changed since my colleagues and I discovered grid cells in 2005, and even since we were awarded the Nobel Prize in 2014. In this article, I will describe the advancements that transformed the field of grid cell research and tell you about the way that we study grid cells today. Finally, I will give you a peek into how we hope to use our understanding of grid cells as a “window” to understanding the brain as a whole.
Hot Chili Peppers Help Uncover the Secrets of Pain
Authors: Julius David
Published: January 2024

Our life experience is shaped by our senses. We see, hear, smell, touch, and taste the things around us, and this is how we get to know the world. In my research, I study receptors—small sensing structures present on cell membranes that react to stimuli from the environment or from within the body. The receptors I tell you about in this article are sensitive to pain and heat, and they respond both to high temperatures and to spicy substances, such as hot chili peppers. We believe that, by studying the structures of these receptors and gaining a better understanding of how they operate, we will be able to develop new drugs to treat long-lasting pain more effectively and safely. Read this article to learn how the chili pepper has opened the door for us to uncover some great mysteries of the sensation of pain, paving the way toward future pain treatments.
The Intersections of COVID-19 Global Health Governance and Population Health Priorities: Equity-Related Lessons Learned From Canada and Selected G20 Countries
Authors: Mac-Seing Muriel , Di Ruggiero Erica
Published: January 2024

Background: COVID-19-related global health governance (GHG) processes and public health measures taken influenced population health priorities worldwide. We investigated the intersection between COVID-19-related GHG and how it redefined population health priorities in Canada and other G20 countries. We analysed a Canada-related multilevel qualitative study and a scoping review of selected G20 countries. Findings show the importance of linking equity considerations to funding and accountability when responding to COVID-19. Nationalism and limited coordination among governance actors contributed to fragmented COVID-19 public health responses. COVID-19-related consequences were not systematically negative, but when they were, they affected more population groups living and working in conditions of vulnerability and marginalisation.

Policy options and recommendations: Six policy options are proposed addressing upstream determinants of health, such as providing sufficient funding for equitable and accountable global and public health outcomes and implementing gender-focused policies to reduce COVID-19 response-related inequities and negative consequences downstream. Specific programmatic (e.g., assessing the needs of the community early) and research recommendations are also suggested to redress identified gaps.

Conclusion: Despite the consequences of the COVID-19 pandemic, programmatic and research opportunities along with concrete policy options must be mobilised and implemented without further delay. We collectively share the duty to act upon global health justice.
Male Reproductive Toxicity of Antifouling Chemicals: Insights into Oxidative Stress-Induced Infertility and Molecular Mechanisms of Zinc Pyrithione (ZPT)
Authors: Panga Mogellah John , Zhao Ye
Published: January 2024

Zinc pyrithione (ZPT), a widely utilized industrial chemical, is recognized for its versatile properties, including antimicrobial, antibacterial, antifungal, and antifouling activities. Despite its widespread use, recent research has shed light on its toxicity, particularly towards the male reproductive system. While investigations into ZPT’s impact on male reproduction have been conducted, most of the attention has been directed towards marine organisms. Notably, ZPT has been identified as a catalyst for oxidative stress, contributing to various indicators of male infertility, such as a reduced sperm count, impaired sperm motility, diminished testosterone levels, apoptosis, and degenerative changes in the testicular tissue. Furthermore, discussions surrounding ZPT’s effects on DNA and cellular structures have emerged. Despite the abundance of information regarding reproductive toxicity, the molecular mechanisms underlying ZPT’s detrimental effects on the male reproductive system remain poorly understood. This review focuses specifically on ZPT, delving into its reported toxicity on male reproduction, while also addressing the broader context by discussing other antifouling chemicals, and emphasizing the need for further exploration into its molecular mechanisms.
Estimating Hardness of Cosmetic Cream Using Electro-Mechanical Impedance Sensing Technique
Authors: Lee Jun-Cheol , Yoo Dan-Hee , Lee In-Chul
Published: January 2024

This study investigates the application of electro-mechanical impedance (EMI) sensing technology to evaluate the hardness of cosmetic creams. Traditional methods, like penetration resistance testing, can be intrusive and disrupt continuous monitoring by impacting internal structures. To overcome this limitation, a piezoelectric sensor is embedded in cosmetic creams to capture EMI signals. This experiment explores varying wax content levels in the creams, establishing correlations between conventional hardness values and EMI signals. The results demonstrate a positive relationship between wax content, hardness values, and the magnitude of EMI resonance peaks. This study emphasizes a robust correlation between established hardness metrics and EMI signals, showcasing the potential of non-destructive testing to drive advancements in cosmetic industry practices.
A Study on the Tribological Behaviors of a Pin Coated with Layer-by-Layer Gold/Nickel Materials within an Electrical Connector
Authors: Zhang Yong , Zhou Xue , Zhang Yue , Wu Daoyi , Wang Xu , Zhai Guofu
Published: January 2024

An electrical connector is an important component for achieving the interconnection of electric equipment. However, the degradation of contacting parts within the electrical connector under repetitive mechanical insertion and extraction operations causes a decrease in the contact reliability level, resulting in considerable safety hazards. The coating quality, determining the degree of degradation of contact pairs, is considered a critical factor in fabricating more reliable and safer electrical connectors. In this paper, a gold and nickel coating is deposited onto the surface of a pin within an electrical connector using magnetron sputtering and is compared to an electroplated pin, and the effects of different processing techniques on the microstructure, mechanical properties, and wear behavior are systematically investigated. The measurement results indicate that the surface quality (uniformity and defect density) and mechanical properties (hardness and elastic modulus) of the gold/nickel coating based on magnetron sputtering are significantly better than those achieved using electroplating, showing excellent wear properties and electrical contact stability after repetitive insertion–extraction operations. This study is critical for the development of advanced coatings using a novel deposition technique.
Research–Practice Partnership in a Professional Development Program: Promoting Youth at Risk
Authors: Miedijensky Shirley , Sasson Irit
Published: January 2024

Research–Practice Partnerships (RPPs) embody enduring collaborations between practitioners and researchers that systematically address practical challenges to enhance education. This study describes research conducted within the framework of an RPP in which researchers were united with an educational association tasked with leading a professional development program (PDP) for teachers serving youth at risk. This study focuses on demonstrating a model for evaluating the implementation of the program’s educational philosophy among PDP participants. This comprehensive model comprises three interlinked components: cultivating awareness of the educational philosophy, fostering a profound comprehension of its principles, and facilitating the application of practices aligned with this philosophy. To investigate these dimensions, we drew upon data gathered through a survey administered to 140 educators and through in-depth interviews with 22 members of the educational staff. By examining these three pivotal components, we not only dissect the implementation process but also identify strengths and weaknesses, paving the way for a tailored intervention strategy. Beyond the immediate implications for program improvement, this research underscores the program’s reciprocal benefits for both researchers and practitioners. It holds the potential to influence the professional development of those involved, concurrently enriching the broader research community with invaluable insights gained from real-world educational contexts.
Cardiac and Nephrological Complications Related to the Use of Antiangiogenic and Anti-Programmed Cell Death Protein 1 Receptor/Programmed Cell Death Protein 1 Ligand Therapy
Authors: Stachyra-Strawa Paulina , Szatkowska-Sieczek Lidia , Cisek Paweł , Gołębiowski Paweł , Grzybowska-Szatkowska Ludmiła
Published: January 2024

The ability to undergo neoangiogenesis is a common feature with all cancers. Signaling related to vascular endothelial growth factors (VEGF) and their receptors (VEGFR) plays a key role in the process of tumor neoangiogenesis. A close relationship has been demonstrated between excessive VEGF levels and the induction of immunosuppression in the tumor microenvironment. The use of drugs blocking the VEGF function, apart from the anticancer effect, also result in adverse effects, in particular related to the circulatory system and kidneys. Cardiac toxicity associated with the use of such therapy manifests itself mainly in the form of hypertension, thromboembolic episodes and ischemic heart disease. In the case of renal complications, the most common symptoms include renal arterial hypertension, proteinuria and microangiopathy. Although these complications are reversible in 60–80% of cases after cessation of VSP (VEGF pathway inhibitor) therapy, in some cases they can lead to irreversible changes in renal function, whereas cardiac complications may be fatal. Also, the use of PD-1/PD-L1 inhibitors may result in kidney and heart damage. In the case of cardiac complications, the most common symptoms include myocarditis, pericarditis, arrhythmia, acute coronary syndrome and vasculitis, while kidney damage most often manifests as acute kidney injury (AKI), nephrotic syndrome, pyuria or hematuria. The decision whether to resume treatment after the occurrence of cardiovascular and renal complications remains a problem.
The Morphology of the Dorsal Part of the First Rib in Neurogenic Thoracic Outlet Syndrome Patients: A Retrospective Clinical Study
Authors: Fox Robert , Lassner Franz , Prescher Andreas
Published: January 2024

Background: The recurrence or persistence of symptoms after thoracic outlet decompression (TOD) in patients with neurogenic thoracic outlet syndrome (NTOS) is not uncommon. Some authors have shown significantly better clinical outcomes in patients who underwent TOD with exarticulation of the first rib compared to a group who underwent TOD with preservation of the dorsal portion of the first rib. Several other case series have shown significant improvement after redo surgery with removal of the dorsal first rib remnant. This indicates the importance of the dorsal part of the first rib in NTOS. However, radical exarticulation may not always be necessary. In this study, we tried to answer the question of whether there is a morphological difference in the dorsal part of the first rib in NTOS patients that might help in the diagnosis and treatment of NTOS. Methods: We used the CT data of 21 NTOS patients who underwent TOD surgery and measured the dorsal part of the first rib, then compared them with a quota sample. Results: We found no difference in the dorsal part of the first rib between NTOS patients and the quota sample in our data. Conclusions: As there was no detectable difference, we were not able to use these data to help decide whether exarticulation is necessary in achieving adequate symptom relief. Therefore, we advocate exarticulation of the first rib when TOD is indicated.
Managing Landscape Urbanization and Assessing Biodiversity of Wildlife Habitats: A Study of Bobcats in San Jose, California
Authors: Zheng Yongli , Wang Yuxi , Wang Xinyi , Wen Yuhan , Guo Shuying
Published: January 2024

In the rapid process of urbanization, crucial habitats for mid-sized felids such as bobcats are increasingly compromised. This study employs Geographic Information System (GIS) tools and Machine Learning to investigate the subtle impacts of urbanization on bobcat habitats. Focused on the San Jose area, our extensive geospatial analysis has developed a complex ecological model for bobcat habitats. Our findings emphasize the significant influence of factors like vegetation cover, water body distribution, road traffic volume, and intersection density on the suitability of habitats for bobcats. Specifically, we discovered that while vegetation cover typically supports habitat suitability, its proximity to busy roads significantly undermines this advantage, indicating a need for strategic urban planning that incorporates wildlife mobility. By synthesizing natural and urban elements, we offer fresh insights into urban ecosystem management and propose specific conservation tactics: identifying optimal wildlife crossings, integrating corridors with urban infrastructure, and placing fencing and signage strategically to facilitate wildlife movement safely. These measures aim to reduce road-related threats and enhance the integrity of natural habitats, strengthening bobcat conservation efforts. More than its direct implications for bobcat conservation, this study offers actionable insights for urban wildlife conservation and introduces innovative methods for assessing and mitigating the broader ecological impacts of urbanization.