bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Necroptosis-Related lncRNA Signature Predicts the Prognosis of Bladder Cancer
Authors: Li Han , Lv Zhengtong , Liu Ming
Published: April 2022

Background: Necroptosis is a programmed necrotic cell death pathway that closely related to tumor progression. Long noncoding RNAs (lncRNAs) have multiple functions in the cancer immunity response. In the study, we aim to construct a necroptosis -related prognostic lncRNA signature in bladder cancer (BC) and explore its precise treatment implications in BC.Methods: We downloaded clinicopathology and transcriptome information from The Cancer Genome Atlas (TCGA) and form the synthetic data matrices and performed coexpression analysis and univariate Cox regression to get the Necroptosis-related prognostic lncRNA. The prediction model was constructed using Lasso regression. The Kaplan-Meier method was used to analyze the overall survival (OS) rate of the high-risk and low-risk groups. Time-dependent receiver operating characteristics (ROC), univariate Cox (uni-Cox) regression, multivariate Cox (multi-Cox) regression were performed to evaluate the model. Gene set enrichment analyses (GSEA), principal component analysis (PCA), immune analysis, and prediction of the half-maximal inhibitory concentration (IC50) in risk groups were also analyzed. Consensus clustering analysis based on necroptosis-related lncRNAs was made to get two clusters to identify hot tumors and cold tumors. Finally, the immunotherapy between the cold and hot tumors was discussed.Results: We constructed a signature composed of 5 necroptosis-related lncRNAs (LINC01140, Z98200.1, AC010168.2, Z84484.1, AC004076.2). Compared with the low-risk group, the high-risk group had a worse prognosis. Compared with clinicopathological variables, the necroptosis -related lncRNA signature demonstrated good predictive ability on the prognosis of patients with BC. The area under the receiver operating characteristic curve of risk score for predicting 5 year OS were 0.690. Immune function and immune checkpoint expression differ significantly between the low-risk and high-risk groups. IC50 between risk groups show that high risk patients were more sensitive to conventional chemotherapy drugs. The cluster 1 was confirmed as hot tumors that had better immune infiltration and immune scores, which is more susceptible to immunotherapeutic and chemotherapy drugs.Conclusion: The necroptosis-related lncRNA signature constructed is convenient to predict prognosis and classify hot or cold tumors of BC patients, so as to achieve precision therapy for BC.
Effects of supplementation of pomegranate processing by-products and waste cooking oils as alternative feed resources in broiler nutrition
Authors: Ghasemi-Sadabadi Mohammad , Ebrahimnezhad Yahya , Maheri-Sis Naser , Shaddel-Teli Abdolahad , Ghalehkandi Jamshid Ghiasi , Veldkamp Teun
Published: April 2022

Agricultural residues can be used as alternative feed sources in industrial chicken production. The impacts of different levels of pomegranate peel and waste cooking oil as an agricultural residue on broilers nutrition were investigated. Results showed that replacement of 8% pomegranate peel in diets decreased growth performance of broilers. Supplementing 8% pomegranate peel in diets reduced apparent nutrient digestibility. The highest level of waste oil inclusion in broiler diets indicated negative impacts on apparent metabolisable energy and crude fat apparent nutrients digestibility. Broilers fed the diet containing 4% pomegranate peel had higher Lactobacillus population. The results showed that Lactobacillus population was lower in broilers fed 8% pomegranate peel powder and 4% waste oil in diets. Inclusion of 8% pomegranate peel powder in diets was showed lower villus height and crypt depth in duodenum, jejunum and ileum. Inclusion of 4% pomegranate peel decreased peroxide value (PV) of meat. Dietary inclusion of 4% waste oil raised PV of meat. Alpha-tocopherol supplementation decreased PV of meat. Finally, the results provide information that 4% of pomegranate peel and 4% waste oil could be used as an alternative feed ingredient in broiler diets without adverse effects.
Chill coma recovery of Ceratitis capitata adults across the Northern Hemisphere
Authors: Papadopoulos Nikos T. , Moraiti Cleopatra A. , Verykouki Eleni
Published: April 2022

The Mediterranean fruit fly, Ceratitis capitata (Diptera: Tephritidae), is an invasive pest, that is currently expanding its geographic distribution from the Mediterranean coasts to more temperate areas of Europe. Given that low temperature is a primary determinant of insect species’ range boundaries especially in the Northern Hemisphere with pronounced seasonality, we used chill coma recovery time for assessing latitudinal clines in basal chill tolerance of C. capitata adults. We selected six populations obtained from areas with broad climatic variability based on the main bioclimatic variables of temperature and precipitation, spanning a latitudinal range of about 19oN from Middle East to Central Europe. Adults were exposed to 0oC for 4h, and time to regain the typical standing position of a fly at 25oC were recorded. The post-stress survival after a period of 8 days was also recorded. Results revealed that adults from Israel and Austria were less chill tolerant than those from Greece, resulting in curvilinear trends with latitude. Analysis of macroclimatic conditions revealed combined effects of latitude (as a proxy of photoperiod) and macroclimatic conditions on chill coma recovery time. Nonetheless, there was not a deleterious effect on post-recovery survival, except for flies obtained from the northern most point (Vienna, Austria). Overall, it seems that evolutionary patterns of basal chill coma recovery time of C. capitata adults are driven mainly by local climatic variability.
Synthesis of composites for the removal of F^- anions
Authors: Damian-Ascencio C. E. , Arcibar J. A. , Guerrero L. , Saldana-Robles A. , Marquez A. , Corona M. , Gallegos-Muñoz A. , Cano-Andrade S.
Published: April 2022

This work presents the synthesis of amine and ferrihydrite func-tionalized graphene oxide for the removal of fluoride from water. The synthesis of the graphene oxide and the modified with amine groups is developed by following the modified Hummer’s method. Fourier transform infrared spectrometry, X-ray, Raman spectroscopy, 1 Springer Nature 2021 L A T E X template S. of Composites for the removal of F − thermogravimetric analysis, surface charge distribution, specific surface area and porosity, adsorption isotherms, and the van’t Hoff equation are used for the characterization of the synthesized materials. Results show that the addition of amines with ferrihydrite generates wrinkles on the surface layers, suggesting a successful incorporation of nitrogen onto the graphene oxide; and as a consequence, the adsorption capacity per unit area of the materials is increased.
Lifelong nnUNet: a framework for standardized medical continual learning
Authors: Gonzalez Camila , Ranem Amin , Santos Daniel Pinto dos , Othman Ahmed , Mukhopadhyay Anirban
Published: April 2022

As the acceptability of Deep Learning solutions grows, both medical practitioners and regulatory bodies are exploring ways to safely introduce image segmentation solutions in clinical practice. One frontier to overcome when translating promising research into the clinical open-world is the shift from static to lifelong learning. Continual learning, the practice of training models sequentially with shifting population dynamics, is seeing growing interest but is still at its infancy in healthcare. We present Lifelong nnUNet, a standardized framework for medical image segmentation that places state-of-the art continual segmentation at the hands of researchers and clinicians. Build on top of the popular nnUNet and equipped with all necessary modules for training and testing continual models, we ensure broad applicability and lower the barrier for evaluating new solutions in a sequential fashion. We introduce benchmark results on three medical segmentation use cases with open-source datasets, and provide the tools to quickly test five continual learning methods on further applications.
GSNOR modulates oxygen and glucose deprivation-induced brain microvascular endothelial cells injury via HIF-1α S-nitrosylation associated mitophagy activation
Authors: Han Zhenping , Wang Siyi , Li Tingting , Gao Li , Zhao Yu , Li Han-bing , Huang Ping , Yan Jie-ping
Published: April 2022

Denitrosylase S-nitrosoglutathione reductase (GSNOR) regulates the equilibrium of total cellular S-nitrosylation levels, a key redox-based post-translational modification that is frequently dysregulated in various diseases. However, the effects and underlying mechanisms of GSNOR on brain microvascular endothelial cells (BMECs) under hypoxia conditions are unknown. In this study, a photothrombosis model was used to induced cerebral ischemia injury in the male C57BL6 mice injury. BMECs were subjected with oxygen-glucose deprivation (OGD) for 6 h to establish the ischemic cell models in vitro. Increased GSNOR levels and S-nitrosylation dysfunctions were observed in cerebral ischemic injury. GSNOR knockdown rescued OGD-induced ischemic injury in BMECs. HIF-1α S-nitrosylation was significantly increased in BMECs after GSNOR knockdown. We investigated the effects of GSNOR on mitochondrial functions and revealed the relationship between HIF-1α translocation and downstream signaling, including mitochondrial bioenergetic functions and activation of mitophagy in BMECs. GSNOR knockdown alleviated OGD-induced mitochondrial impairments. Moreover, GSNOR reduced excessive mitochondrial reactive oxygen species (ROS) production, thereby, alleviating mitochondrial oxidative stress. GSNOR knockdown also enhanced the disturbance of cellular bioenergetic functions and BNIP3L/NIX-mediated mitophagy. Expression levels of mitophagy-related proteins, such as LC3B, BNIP3L/NIX, and FUNDC1were significantly elevated in GSNOR knockdown detected by western blot. These results suggest that the knockdown of GSNOR knockdown alleviates mitochondrial toxicity by promoting HIF-1α S-nitrosylation-associated repair of mitochondrial functions and activating mitophagy in BMECs. Understanding the protective effects of GSNOR provides a novel strategy for developing potential therapies targets for ischemic injury in BMECs.
Global stability and bifurcation of macroscopic traffic flow models for upslope and downslope
Authors: Cen Bing-Ling , Xue Yu , Qiao Yan-Feng , Wang Yi , Pan Wei , He Hong-Di
Published: April 2022

A macro continuum model of the traffic flow is derived from a micro car-following model that considers both the upslope and downslope by using the transformation relationship between macro- and micro variables. The perturbation propagation characteristics and stability conditions of the macroscopic continuum equation are discussed. For uniform flow in the initial equilibrium state, the stability conditions reveal that as the slope angle increased under the action of a small disturbance, the upslope stability increases and downslope stability decreases. Moreover, under a large disturbance, the global stability analysis is carried out by using the wavefront expansion technique for uniform flow in the initial equilibrium state. For the initial nonuniform flow, nonlinear bifurcation analysis is conducted at the equilibrium point. Subcritical Hopf bifurcation exists when the traffic flow state changes,thus the limit cycle formed by the Hopf bifurcation is unstable. Simulation results verify the stability conditions of the model and determine the critical density range. The numerical simulation results show the existence of critical Hopf bifurcation in phase space, and the spiral saddle point varies with the slope angle. Furthermore, the impact of the angle of both the upslope and downslope on the evolution of density waves is investigated.
Variations in uniform hazard spectra and disaggregated scenarios during earthquake sequences
Authors: Azarbakht Alireza , Douglas John
Published: April 2022

Seismic hazard varies greatly during an earthquake sequence. Understanding this variation can be useful to end-users, such as emergency managers, as it would enable them to make more informed decisions about potential risk reduction measures. This article presents examples of how two commonly-used products of probabilistic seismic hazard assessments: uniform hazard spectra and disaggregated earthquake scenarios, vary during two seismic sequences in western Greece. These calculations are made using a recent time-dependent seismic hazard model based on a Bayesian ETAS approach. The examples show that time-dependent uniform hazard spectra for short return periods (1 and 10 years) are significantly higher than standard time-independent spectra but that uniform hazard spectra for the commonly-used return periods of 475 and 2475 years are similar to those from time-independent assessments. The time-dependent spectra generally converge within a couple of days to the time-independent spectra. The examples also show that the dominant earthquake scenarios evidenced by the disaggregation for the time-dependent assessment can show significant differences from the time-independent scenarios. This is particularly true when the earthquake sequence is distant from the location of interest as the aftershocks contribute greatly to the overall hazard. To show these changes more clearly this article introduces a new graphical representation of the disaggregated results.
Two novel qPCR assays to enhance black rail (Laterallus jamaicensis) eDNA surveys in the United States
Authors: Feist Sheena M. , Guan Xin , Malmfeldt Madeleine P. , Lance Richard F.
Published: April 2022

Black rails (Laterallus jamaicensis) are a rare and protected bird species. They are also notoriously difficult to monitor. eDNA surveys have proven beneficial for the detection of this elusive species, but additional developments are needed to enhance eDNA survey utility (including reliability of outcomes) in light of black rail status and associated high-profile conservation actions. The use of multiple assays functions to increase eDNA detection confidence by increasing the probability of amplification in low concentration, highly degraded samples (i.e., reducing the risk of false negatives) and by providing a multiplicative test for ruling out contamination as the source of qPCR amplification (i.e., reducing the risk of false positives). The two eDNA assays developed, optimized, and validated in this study will prove valuable for the continued surveillance of the secretive black rail, offering data to measure its distribution and occurrence over time and as influenced by anticipated climate-change-induced disturbances and/or habitat restoration/creation initiatives. The assays are applicable to both Eastern black rails and California black rails, and do not exhibit qPCR amplification in non-target, co-distributed taxa (including other Rallidae species) in the United States.
Analgesic Medications for Pain Treatment in a ICU
Authors: Belice Tahir , Akdoğan Berivan , Demir İsmail
Published: April 2022

Aim
Pain management requires a broad and multidisciplinary approach that includes physical, psychological and spiritual domains. In this study, we provide the rates and types of painkillers that have been used in a ICU with demographics and mortality rates.
Methods
Patients charged in the ICU were found over the Probel registry system, and the number and types of painkillers, mortality rates, age and gender of the patients were recorded in excel and analyzed with SPSS. Independent T test and one way ANOVA were used to correlate variables
Results
A total of 283 subjects was included in this study with 143 (50.5%) women and 140 (49.5%) men. The numbers of ICU patients that were under 65 years old and aged 65 and over were 88 (31.1%) and 195 (68.9%), respectively. The number of patients that was not administered analgesics was 172 (%60.8) while the number of participants that was administered was 111 (39.2%). The number of single analgesic usage was 83 (29.3%), whereas the number of two analgesics or three were 3 (1.4%) and 23 (8.1%), respectively.
Conclusions
Pain management is a complex and difficult process and it is possible to obtain more effective results when it is planned as comprehensive and multidisciplinary.
The prognostic utility of neutrophil-lymphocyte ratio in spinal surgery: systematic review protocol
Authors: Osunronbi Temidayo , Olukoya Olatomiwa , Sharma Himanshu
Published: April 2022

Neutrophil-lymphocyte ratio has been extensively reported to predict patients' outcomes in fields such as cancer, cardiac surgery, infection, and stroke medicine. However, there is no consensus on the prognostic utility of NLR in spinal surgery patients. Hence, this systematic review aims to analyse existing evidence and evaluate the relationship between NLR and outcome measures in spinal surgery patients. This is a study protocol describing our systematic review methods.
Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain
Authors: Itson-Zoske Brandon , Shin Seung Min , Xu Hao , Qiu Chensheng , Fan Fan , Hogan Quinn H. , Yu Hongwei
Published: April 2022

Background
Peripheral and central nociceptive sensitization is a critical pathogenetic component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (CaV3.2) regulates neuronal excitability and plays important roles in pain processing. We previously identify that enhanced T-type/CaV3.2 activity in the primary sensory neurons (PSNs) of dorsal root ganglia (DRG) is associated with neuropathic pain behavior in a rat model of monosodium iodoacetate (MIA)-induced knee OA. PSN-specific T-type/CaV3.2 may therefore represent an important mediator in OA painful neuropathy. Here we test the hypothesis that the T-type/CaV3.2 channels in PSNs can be rationally targeted for pain relief in MIA-OA.
Methods
MIA model of knee OA was induced in male and female rats by a single injection of 2 mg MIA into intra-knee articular cavity. Two weeks after induction of knee MIA-OA pain, recombinant adeno-associated viruses (AAV)-encoding potent CaV3.2 inhibitory peptide aptamer 2 (CaV3.2iPA2) that have been characterized in our previous study was delivered into the ipsilateral lumbar 4/5 DRG. Effectiveness of DRG-CaV3.2iPA2 treatment on evoked (mechanical and thermal) and spontaneous (conditioned place preference) pain behavior, as well as weight-bearing asymmetry measured by Incapacitance tester, in the arthritic limbs of MIA rats were evaluated. AAV-mediated transgene expression in DRG was determined by immunohistochemistry.
Results
AAV-mediated expression of CaV3.2iPA2 selective in the DRG-PSNs produced significant and comparable mitigations of evoked and spontaneous pain behavior, as well as normalization of weight-bearing asymmetry in both male and female MIA-OA rats. Analgesia of DRG-AAV-CaV3.2iPA1, another potent CaV3.2 inhibitory peptide, was also observed. Whole-cell current-clamp recordings showed that AAV-mediated CaV3.2iPA2 expression normalized hyperexcitability of the PSNs dissociated from the DRG of MIA animals, suggesting that CaV3.2iPA2 attenuated pain behavior by reversing MIA-induced neuronal hyperexcitability.
Conclusions
Together, our results add therapeutic support that T-type/CaV3.2 in primary sensory pathways contributes to MIA-OA pain pathogenesis and that CaV3.2iPAs are promising analgesic leads that, combined with AAV-targeted delivery in anatomically segmental sensory ganglia, have the potential for further development as a peripheral selective T-type/CaV3.2-targeting strategy in mitigating chronic MIA-OA pain behavior. Validation of the therapeutic potential of this strategy in other OA models may be valuable in future study.
Evidence-based analysis of the SARS-CoV-2 furin site origin
Authors: Romeu Antonio R.
Published: April 2022

The origin of the SARS-CoV-2 is still unclear. Simply said, its emergence is due to the acquisition of the polybasic furin cleavage site on the S protein in one of its closest relatives. The recent discovery in Laos of bat Rhinolophus coronaviruses that contain receptor binding domains almost identical to that of SARS-CoV-2, and despite not having the furin site, they can therefore infect human cells (1), is the cornerstone to identify the SARS-CoV-2 progenitor. However, it is not yet known where the insertion of the furin site at the S1/S2 junction in the S protein of the pandemic virus came from. Not only from where, but also how, where and when of such acquisition. The most surprising was: (i) that the polybasic furin cleavage site is unique to SARS-CoV-2 among Sarbecovirus (2), and (ii) that the inserted four amino acid motif has a CGG-CGG encoded arginine pair which is rare in coronaviruses (3). So, my question is if the SARS-CoV-2 insert in the S gene insert would match to human transcripts. Here, I address this issue by using NCBI and GISAID databases, the NCBI Human Genome Resources, sequence analysis tools and in-house developed bioinformatic tools. I found that the 12-nucleotide insert encoding SARS-CoV-2 furin site 100% match to several human transcripts. Taken together the presence of these human transcripts and the expression patterns their genes, results provide insight into human potential recombination link to SARS-CoV-2 furin cleavage site, during undetected human-to-human virus transmission.
Significance of the Expression of pAKT1 and pSyk Activation Proteins in Diffuse Large B-Cell Lymphoma
Authors: Vaneeva Elena Viktorovna , Rosin V.A. , Dyakonov D.A. , Samarina S.V. , Paramonov I.V.
Published: April 2022

Background. Diffuse large B-cell lymphoma (DLBCL) amounts for 30-40 % of all adult non-Hodgkin's lymphomas. After R-CHOP immunochemotherapy 40 % of patients develop early relapsed or therapy-refractory disease. The conventional prognostic parameters in DLBCL are not always effective. Therefore, exploring further predictors of disease course remains an issue. Aim. To assess the prognostic value of pAKT1 and рSy< expression in DLBCL. Materials & Methods. The study enrolled 100 patients with newly diagnosed DLBCL treated with R-CHOP first-line immunochemotherapy. The relative count of pAKT1- and pSyk-expressing tumor cells was determined by immunohistochemical and morphometric methods. The expression cutoff of these proteins was calculated by ROC analysis. The relationship of protein expression with clinical parameters of DLBCL was analyzed by Fisher's exact two-tailed test. The 5-year overall (OS) and progression-free (PFS) survivals were estimated by Kaplan-Meier method (log-rank test). Results. High pAKT1 expression was associated with advanced DLBCL stages, International Prognostic Index > 2, serum lactate dehydrogenase concentration above normal, failures of R-CHOP therapy, as well as worse OS and PFS. No correlation between рSyk< expression and clinical lymphoma characteristics was found. The worst 5-year OS (27.6 %) was reported in cases of pAKT1 and pSyk co-overexpression (hazard ratio [HR] 5.2; 95% confidence interval [95% CI] 2.49-10.9; p < 0.001). A similar trend was observed for PFS (HR = 3.3; 95% CI 1.54-7.30; p = 0.002). Conclusion. Overexpression of pAKT1 is an informative indicator of a poor DLBCL prognosis. Co-overexpression of pAKT1 and рSyk< markers is associated with worse OS and PFS compared to their isolated expressions and other co-expression variants.
UTERINE RUPTURE IN HEALTHY UTERUS: ABOUT 2 CASES AT THE SOUISSI MATERNITY HOSPITAL IN RABAT RUPTURE UTERINE SUR UTERUS SAIN : A PROPOS DE 2 CAS A LA MATERNITE SOUISSI DE RABAT
Authors:   Service De Gynecologie Obstetrique Et Dendocrinologie / CHU Rabat., Nisrine Benaouicha , F.Z Louzali ,   Service De Gynecologie Obstetrique Et Dendocrinologie / CHU Rabat., S. Badsi ,   Service De Gynecologie Obstetrique Et Dendocrinologie / CHU Rabat., a Lakhdar ,   Service De Gynecologie Obstetrique Et Dendocrinologie / CHU Rabat., b Baydada ,   Service De Gynecologie Obstetrique Et Dendocrinologie / CHU Rabat., Aicha Kharbach ,   Service De Gynecologie Obstetrique Et Dendocrinologie / CHU Rabat.
Published: April 2022

Uterine rupture is a rare complication of labor that presents a vital risk for the mother and the fetus as well as the obstetrical outcome of the woman. It is more frequent in case of scarred uterus and very rare in case of healthy uterus. We report in our work 2 cases of uterine rupture on healthy uterus. We discuss through these 2 cases and the review of the literature, the alarming clinical signs, the risk factors, the diagnostic methodology and the therapeutic management of this rare but potentially serious entity.
STUDY OF HEMOTOLOGICALPROFILE AND SERUM IRON INDICES IN CHRONIC KIDNEY DISEASE IN TERTIARY CARE CENTRE
Authors: Balakrishnan Nivedha , Arumugam K.E.
Published: April 2022

Background:Chronic kidney disease (CKD) is an emerging public health problem worldwide, with increasing cost of healthcare particularly in developing countries like India. Haematological parameters are generally influenced in CKD and the effect increases with the stage of CKD. Haematologicalprofiles are rarely investigated in CKD subjects in our population. This studywas conducted to determinethehaematological profile and serumiron indices in non-dialysis chronic kidney disease patients. Materialsandmethods:The present cross-section was conducted at KarapagaVinayaga Medical College, Chengalpattu. A total of 153 patients aged above 18 were recruited by purposive sampling. Thorough clinical examination and investigation complete blood count,reticulocyte,count serumureaand creatininewereanalysed.Datawereanalysed,andstatisticalcalculationswere carriedoutusingSPSSversion19.0.Means,rangeandmedianwerefoundtorepresentthedata appropriately. Chi-Square tests are used for association. A P-value of <0.05 was considered significant. Results: The mean duration of illness ranged from 3 months to 27 months, with an average of 8.66 months.Nearly34%oftheparticipantshaddiabetesmellitus,29%hadhypertensionand25% were smokers. Our reveals that there were statistically significant differences seen in associationbetweenCKDstagesandHaematologicalparametersHb(gm/dl),PCV%,Platelet count(lakhs/cumm). Conclusion:Anemia is a leading cause of morbidity in CKD patients, and it worsens with disease stage. The evaluation of Hb and RBC parameters in CKD patients aids in classifying the type of anaemia,aidingintheselectionofappropriatetreatmentmodalities,andavoidingunnecessary iron overload in these patients.
A MUSIC GENERATION BY A COMBINING MODELOF RESNET AND LSTM NETWORKS
Authors:   Graduate School of Electrical and Information Engineering, Shonan Institute of Technology, 1-1-25 Tsujido Nishikaigan, Fujisawa 251-8511, Japan., Ozawa Kazuya , Okazaki Hideaki ,   Graduate School of Electrical and Information Engineering, Shonan Institute of Technology, 1-1-25 Tsujido Nishikaigan, Fujisawa 251-8511, Japan.
Published: April 2022

In this paper, to automatically generate a music for the melody part by deep learning with training data collected from Chopins piano piecies, a combining model of Residual Neural Networks(ResNet) and Long-Short Term Memory Networks (LSTM) are proposed. First, to generate a music for the melody part of a piano music, a training dataset used for deep learning is provided. Secondly, by using each of a LSTM Model and a combining model of LSTM and ResNet,experiments on music generationare presented. Thirdly, the results of music generation by each model are compared and discussed. In conclusion, the principal results are summarized.
CANCER AND ITS TREATMENT: AN OVERVIEW
Authors:   Sister Nivedita University, Kolkata., Tewari Muskan
Published: April 2022

Cancer is a disease in which abnormal cells of the body grow uncontrollably ultimately causing harm to the body. The property of contact inhibition is absent in cancerous cells and thus they proliferate disorderly giving rise to tumors. Here we throw light on cancer prevention, different types of cancer, treatment methods currently available for cancer and also the recent advances in cancer treatment. Since the last couple of decades cancer cases have increased drastically, but at the same time due to advancement in science and technology, the mortality rate is decreasing. Cancer treatment is provided depending upon its type and stage. Apart from the conventional treatment like surgery, chemotherapy, radiation therapy, hormone therapy etc, some rapidly emerging treatment methods are immunotherapy, targeted therapies such as small molecule tyrosine kinase inhibitors and monoclonal antibodies (MABs) and gene therapy. Immunotherapy has rapidly transformed treatment methods for many types of cancer and one more encouraging step towards cancer immunotherapy is the use of personalized vaccines. The standard therapy methods do cure cancer but along with that they pose serious threat to normal healthy cells as well as have side effects, due to this reason, new treatment methods are being adopted.
FETO-MATERNAL OUTCOMES IN HYPERTENSIVE DISORDERS OF PREGNANCY IN A TERTIARY CARE HOSPITAL: A RETROSPECTIVE STUDY
Authors:   Department of Obstetrics &Gynaecology, Mahatma Gandhi Medical College & Hospital, Jaipur, India., Juneja Umang , Patel Harsh ,   Department of Obstetrics &Gynaecology, Mahatma Gandhi Medical College & Hospital, Jaipur, India.
Published: April 2022

Introduction: Hypertensive disorders are the most common Medical disorders encountered during pregnancy occurs in approximately 7% to 10% of all pregnancies. HDP are associated with fetal growth restriction, perinatal asphyxia, iatrogenic prematurity, stillbirths, preterm delivery, perinatal death, neonatal mortality and affects vital maternal organ system such as renal, hepatic, cardiorespiratory, feto-placental and hematologic. Methods: Hospital based descriptive cross-sectional retrospective study was conducted to find the incidence and evaluate the foeto-maternal outcome in 1462 women with HDP who delivered in our hospital. Result: 151 (10.32%) were diagnosed to have HDP of which 8 (5.29%) had eclampsia, 7 (4.63%) had chronic hypertension, 42 (27.8%) had mild pre-eclampsia, 25 (16.55%) had severe eclampsia and 69 (45.69%) had gestational hypertension. 70.19% belonged to the age group of 18 to 27 years. Incidence was almost equal in multigravida and primigravida i.e. 51.65% and 48.34% respectively. Patients who delivered vaginally were 54.96% while remaining were delivered out by LSCS mostly due to foetal distress. 82.11% (124/151) presented with no maternal complication. 17.88% cases had significant morbidity. Most complication were seen in the eclampsia group. Out of 151 deliveries, 81 (53.64%) had no adverse fetal complication. 6 had IUD/Stillbirth. Prematurity was seen in 62.91% babies while 50% were LBW babies. 38.46% needed ICU admission out of which 13 required ventilator support. Conclusion: HDP is one of the major health problems seen in pregnancy & is associated with a huge burden of maternal and perinatal morbidity and mortality.
CULTURAL STUDIES IN RUDALI- A PERSPECTIVE OF MAHASWETA DEVI
Authors:   Research Scholar, School of Social Sciences and Languages, Vellore Institute of Technology, Chennai, Tamil Nadu, India., D. Shalini , C. Alamelu ,   Professor, School of Social Sciences and Languages, Vellore Institute of Technology, Chennai, Tamil Nadu, India.
Published: April 2022

This paper analyses the culture of Ganju community and highlights social exclusion and oppression by the high-class people of the same village in the work of the social activist Mahasweta Devis, Rudali,. In this novella, Mahasweta Devi brings out how the marginalised community and economically down-trodden people are oppressed by the higher-class people in the same village. Through the female protagonist, she portrays the sufferings inflicted by the society on the down-trodden women who are abandoned by their families. She depicts the practise of a particular community which becomes her identity in society which subjugates her. Not only that, it also discusses about the subjugation of men by the zamindars in the village for their needs, which was also one of the reasons for the tragic life of women belonging to their family. The novella also focuses on the beliefs, practices and the culture of the Community and the social and economic aspects as well.
A CASE SERIES ON MENINGIOMA BASED ON WHO GRADING SYSTEM
Authors:   PG Resident, D. Y. Patil Medical College Kolhapur., Tyagi Lavi , Patil R.S ,   Associate Professor, D. Y. Patil Medical College Kolhapur., Pawar V.R ,   Professor, D. Y. Patil Medical College Kolhapur.
Published: April 2022

Background:The dura mater, arachnoid mater and pia mater are layers of meninges surrounding brain and spinal cord. Meningiomas are tumors arising from them.These are heterogeneous group of tumors and are have 14 distinct histologic types and 03 grades of malignancy.We have studied the variants of meningiomas, as early detection helps in the treatment and improves quality of life. Objectives: -Study the histological types as per WHO grading system 2016 for meningiomas. -Differentiate the benign and malignant meningiomas on histopathology. Methods: The study is carried out in the department of pathology, D.Y. Patil medical college and hospital kolhapur from June 2020 to June 2021. Total 19 intracranial tumors were received. Sections were stained with H&E and IHC was done wherever necessary. Results:We had total 19 patients with tumors in different locations of brain. Mainly parasagital followed by intradural . Age range was 32 to 70 years with female predominance. Common histological subtypes were meningothelial (5 cases) and fibrous (5 cases), followed by transitional and angiomatous (2 cases each) and psamomatous (1 case) - WHO grade I tumors. Clear cell and atypical - grade II. Papillary, anaplastic variant - grade III. Conclusion: Meningiomas are slow growing tumors arising from the meningothelial cells. Commonly they are benign WHO grade I with female predominance. Early detection helps in the treatment and improves quality of life.
TO ASSESS THE KNOWLEDGE OF ILL EFFECTS OF GUTKHA CHEWING AMONG ADOLESCENCE MALE IN SELECTED HIGH SCHOOLS AND JUNIOR COLLEGES
Authors: George Stephen Ruda
Published: April 2022

Given the current pattern of tobacco use globally, it is estimated that 250 million Adolescent who are aliv today,would die prematurely because of consumptionof tobacco products. It is recommended that appropriate knowledge about ill effects of tobacco product (gutkha) The Objectives Of The Study Were: 1. To assess the knowledge of adolescent about ill effects of gutkha chewing . 2. To find out association between knowledge and selected demographic variables. 3. To develop information booklet to improve their knowledge based on ill effects on human body of gutkha chewing for adolescent male. Methods:The descriptive survey approach was adopted to collect data by self prepared structured questionnaire and administered to 50 High school and junior college male students, who were selected by using non probality purposive sampling technique at various high schools and junior colleges of Ghataprabha.
BARRIERS OF PHYSICAL ACTIVITY AMONG DIABETIC PATIENTS IN AL MADINAHALMUNAWARAH 2021
Authors:   Department of Family Medicine Academy, Al Madinah Al Munawarah, SaudiArabia., M. Alloqmani Sami , Alahmadi Abdullah ,   Preventive Medicine Department, Al Madinah Al Munawarah, Saudiarabia.
Published: April 2022

Aim:To explore the barriers of individuals diagnosed with type 2 diabetes in relation to physical activity, and to compare between age ,gender and level of educations . Background:diabetic patients may have a lot of complications developed if not fellow management plan that include physical activities. By knowing barriers of physical activities they will improve quality of life.Such research is vital inorder to identify these barriers and try to eliminate. Methods: Descriptive-analytical approach research conducted in diabetic center of King Fahad hospital in Al Madinah AlMunawarah. three hundred seventy seven diabetic type 2 patients filled questioners that includes barriers of physical activities . Results:Lack of willpowershows significant barriers of physical activities among study members especially female (94.4% of them) rather than male(90.7% of them). The results also illustrated lack of energy was statistically significant among the study sample members of the female population (97.0% of them) while males (91.0% of them). Young members (15-29)shows all of them have Lack of time as barrier. primary certification(96.2% of them) suffered from lack of social support and (87.2% of them)suffered from lack of skills. The resultsillustrate there significant differences among the study sample members with university certification, where 99.0% of them suffered from lake of energy. Conclusions:lack of willpower and energy shows significantly barriers among female while lack of social support and skills were barriers of low level educated patient.High level of education has lack of energy.lack of time was obvious withyoung patients.
A PRE-EXPERIMENTAL STUDY TO EVALUATE THE EFFECTIVENESS OF BUERGER ALLEN EXERCISE ON LEVEL OF LOWER LIMB TISSUE PERFUSION AMONG PATIENT WITH DIABETES MELLITUS ADMITTED IN SELECTED HOSPITAL U.P
Authors:   Assistant Professor, School of Nursing Science and Research, Sharda University., Chauhan Shiva , Sharma Kiran ,   Professor, School of Nursing Science and Research, Sharda University.
Published: April 2022

The objectives of the study were: (I) To assess the level of lower limb tissue perfusion among patient with diabetes mellitus before and after administration of buerger Allen exercise. (II) To evaluate the effectiveness of buerger Allen exercise on the level of lower limb tissue perfusion among patient with diabetes mellitus. (III) To find out the association between post interventional scores of lower limb tissues perfusion with the selected demographic variables. The Conceptual framework adopted for the study was based on Health Promotion Modal proposed by Nola J. pander in 1992. Quantitative Research Approach was adopted with Pre experimental: one group pre-test - post-test design. The tool used for the date collection demographic variables and Tissue Perfusion Scale with Seven Parameter for assessment of lower limb tissue perfusion. Content validity of the was done by 9 experts from the field of medicine and Nursing. The obtained data was analyzed using both descriptive and inferential statistic in terms of Frequency, Percentage, Mean, and Mean, deference, Standard Deviation, t value and Chi-square. Major finding of the study are majority 43.3% (13) in the age group of 30-40 years. Mean post Tissue Perfusion score was higher than the Mean Tissue Perfusion score. To obtain the difference between pre and post Tissue Per score was found to be statistically significant at 0.05 level of significant. The finding of study revealed that implementation of Buerger Allen Exercise was effective for Improving Level of Lower Limb Tissue Perfusion. Majority of patients were felt relaxed and Buerger Allen Exercise used by the researcher was accepted, Buerger Allen Exercise is non-invasive, non-pharmacological and effective mean which can be used for diabetes mellitus patients as a routine practice. Based on the research finding further recommendation also given.
ATTITUDE OF TEACHERS TOWARDS TEACHING AND WORK ENVIRONMENT: A COMPARATIVE STUDY BETWEEN PUBLIC AND PRIVATE SCHOOLS IN RURAL WEST BENGAL
Authors:   Assistant Professor, Department of Education, Acharya Prafulla Chandra College, New Barrackpore, Kolkata 700131., Kumar Nanda Gouri , Das Arabinda ,   Assistant Professor, Department of Statistics, Acharya Prafulla Chandra College, New Barrackpore, Kolkata 700131.
Published: April 2022

Teachers attitude towards teaching facilities and feasibilities and work environment play an important role in elementary education in this era where parents have enough choice for their children. This study was conducted in rural areas of West Bengal on teachers attitude on teaching facilities and work environment of private and public schools. The study found award for good deed, extra administrative works, strict regulations against sexual harassment and bullying, and participation in conducting co-curricular activities are related with gender of teachers. Also, healthy work environment, co-operation from non-teaching staff, extra administrative works, lack of technical facility for advanced teaching, regular skill enhancement for teachers, were given preference by the teachers who were trained. Moreover, having white board, regular skill enhancement for teachers, and award for good deed were preferred by the teachers with private school.
FOR A QUALITY PRESCHOOL IN THE ERA OF THE NEW MOROCCAN DEVELOPMENT MODEL
Authors:   Faculty of Education Sciences- Rabat Coordinator of the Degree in Preschool Education Boulevard Mohammed Ben Abdellah Regragui, Rabat 10000., Bentaibi Rachid
Published: April 2022

This article is intended as a contribution to the problem of generalising the quality of preschool education in Morocco in the era of the new development model by pointing out certain dysfunctions likely to slow down the growth and progress of pre-school education and by proposing avenues for reflection and improvement based on a cross-cutting and interdisciplinary approach that would make it possible to prepare tomorrows citizens to better meet the challenges they will have to face and to promote their learning in a motivating environment. The pedagogical quality requirements of pre-school education differ greatly from those of other levels of education. However, it is the pillar on which the new Moroccan school must be built, insofar as it forms the basis for the generalisation of quality education. The current objective of pre-school education is to improve the childs preparation for school and, more broadly, his or her proper development. It offers the possibility of acquiring a set of skills, psychological aptitudes, cognitive abilities, human and social values in order to enable them to succeed in their initiation ritual of integration into the social body and with a view to establishing a more harmonious human society that is also open to the challenges of inclusion and development of tomorrow. At a time when the progress report on the promotion of pre-school education has recorded positive results resulting in an increase of 72.5% by the end of 2021, the success of quality pre-schooling still depends on the requirements relating to measures to improve quality (inclusion, programme and content), human resources and governance. The originality and value of this article can be summed up by the fact that it provides avenues for reflection and improvement based on a cross-cutting and interdisciplinary approach that would make it possible to prepare tomorrows citizen children to better meet the challenges they will face and to promote their learning in a motivating environment.
PFGE GENOTYPING OF METALLO BETA LACTAMASE PRODUCING PSEUDOMONAS AERUGINOSA
Authors:   Sir H.N. Medical Research Society, Sir H.N. Reliance Foundation Hospital & Research Centre, Mumbai-400 004, Maharashtra, India., Pal R.B. , Pathak Upasana ,   Sir H.N. Medical Research Society, Sir H.N. Reliance Foundation Hospital & Research Centre, Mumbai-400 004, Maharashtra, India.
Published: April 2022

Purpose: Indiscriminate use of antibiotics since a long time has led to the emergence of organisms resistant to many antibiotics. This study was carried out for genotyping of metallo beta lactamase (MBL) producing P.aeruginosausing pulsed field gel electrophoresis (PFGE) and compare the PFGE pattern with the antibiotic susceptibility pattern obtained. Methods: In this study the MBL producing P.aeruginosa isolates were subjected to antibiotic sensitivity test against 9 antibiotics and further subjected to PFGE to determine their genetic pattern. Results: All the isolates were resistant to meropenem(10Î¼g) and 88% were resistant to imipenem(10 Î¼g). Isolates showed maximum sensitivity to amikacin (30 Î¼g) and ciprofloxacin (5Î¼g).Identical PFGE pattern was observed in 23 out of 25 isolates and 2 isolates were found to have completely different pattern. Conclusion: Our findings show a dominant genomic pattern of the MBL isolates although the phenotypic antibiotic resistance test showed no conclusive phenotypic pattern.
TWINPREGNANCY BI CHORIAL COMPLICATEDWITHEXOMPHALOS OF ONE TWIN : CASE REPORT
Authors: Safae Badsi , Fatima Zohra Louzali , Nisrine Benaouicha , Najia Zeraidi , Amina Lakhdar , Aicha Kharbache , Aziz Baidada
Published: April 2022

Omphalocele (exomphalos) is one of the mostcommoncongenital malformations of the abdominal wall. The size of the defect and the severity of the associatedabnormalitiesdetermineoverallmorbidity and mortality. Prenatal screening and diagnosis of associatedabnormalities are important for proper management. The purpose of this article is to discuss the approach of prenataldiagnosis and the therapeuticmodalities of omphalocÃ¨le through a case reportedwithinourobstetricgynaecologydepartment CHU IBN SINA RABAT.
STUDY IN TRANSIENT REGIME BY ANALYTICAL METHOD OF THERMAL TRANSFER THROUGH AN INSULATING MATERIAL BASED ON TYPHA AND TWO-DIMENSIONAL (2D) CLAY: INFLUENCE OF THE THERMAL EXCHANGE COEFFICIENT ON THE FRONT FACE
Authors:   Laboratory of Semiconductors and Solar Energy, Physics Department, Faculty of Science and Technology, University Cheikh Anta Diop, Dakar, Senegal., Faye Seydou , Dione Babou ,   Laboratory of Semiconductors and Solar Energy, Physics Department, Faculty of Science and Technology, University Cheikh Anta Diop, Dakar, Senegal., Touty Traore Papa ,   Laboratory of Semiconductors and Solar Energy, Physics Department, Faculty of Science and Technology, University Cheikh Anta Diop, Dakar, Senegal.
Published: April 2022

In this study, we propose an analytical method of heat transfer for the determination of temperature and heat flux density of a typha-clay material. The expression for the temperature and the heat flux density are obtained from the resolution of the heat equation. The influences of the exchange coefficient at the front face and of the depth in the material are highlighted in the transient dynamic regime in two dimensions.
A REVIEW ON MATHEMATICAL MODELS FOR NANOPARTICLE DELIVERY IN THE BLOOD
Authors:   Department of Mathematics, School Of Basic & Applied Sciences, Harcourt Butler Technical University, India, 208002., Bali Rekha , Prasad Bhawini ,   Department of Mathematics, School Of Basic & Applied Sciences, Harcourt Butler Technical University, India, 208002., Mishra Swati ,   Department of Mathematics, School Of Basic & Applied Sciences, Harcourt Butler Technical University, India, 208002.
Published: April 2022

One of the ubiquitous causes of deaths are the Cardio Vascular Diseases or CVDs. The implementation of nanotechnology in the treatment of CVDs has evinced better bio-compatibility and enhanced cell interactions. This provides a strong potential for their mathematical modeling with the diseased blood vessels. In our current study we have reported various mathematical models used for the treatment of CVDs employing nanotechnology. Mathematical modeling provides a tool to comprehend the type, shape and size of the nanoparticles that can be employed as possible drug delivery systems. Mathematical models help to predict how nano-drugs have many improvements like expanded drug loading capacity and programmable pharmo-kinetic properties over the conventional drugs. The amalgamation of mathematical models with clinical data provides for designing these optimal therapies. This review encapsulates the current state of mathematical modeling approaches to treat CVDs using nanoparticle targeted drug delivery.