bluuebunny/crossref_metadata_2025 huggingface dataset:
Nitrogen-containing Fused Heterocycles: Organic Synthesis and Applications as
Potential Anticancer Agents
Authors: Ledade Pankaj V. , Lambat Trimurti L. , Gunjate Jitendra K. , Chopra Paavan K.P.G. , Bhute Amitkumar V. , Lanjewar Mamata R. , Kadu Pooja M. , Dongre Utpal J. , Mahmood Sami H.
Published: December 2022

The fused Nitrogen heterocyclic compounds and their derivatives have grown in
prominence over the past several decades as a result of their significant medical value. The
adaptable and easily synthesized N-Heterocyclic scaffolds are particularly exciting in both
synthetic organic chemistry and the biological sector due to their powerful pharmacological
properties, which are taken into consideration while considering their numerous uses. For the
synthesis of N-heterocycles and their derivatives, several attempts were undertaken to create a
variety of synthetic protocols. The N-Heterocyclic compounds provide a variety of adaptable
structures for specific biological applications and represent novel, broad-spectrum antibacterial
and anticancer agents. They typically have minimal toxicity profiles. The majority of these
N-Heterocycles have demonstrated more cytotoxicity than the effective anticancer medication
cisplatin. The design, synthesis, structural characterisation, and biological uses of N-Heterocycles are reviewed
in this work. In this article, the developments made in this specific field are comprehensively examined.
Time- and Concentration-Dependent Stimulation of Oxidative
Stress in Chondrocytes by Intracellular Soluble Urate
Authors: Zhang Bingqing , Di Hong , Zhang Yun , Han Xinxin , Yin Yue , Han Yingdong , Cao Yu , Zeng Xuejun
Published: December 2022

Background:

Gout could result in irreversible bone erosion, and chondrocyte
might be involved in the process. Increased soluble urate is the early stage of
gout and is strongly oxidative.

Objective:

To explore the effect of intracellular urate on the oxidative status of chondrocytes

Methods:

A chondrocyte model was used. Serial concentrations of exogenous urate
were incubated with chondrocytes for increasing amounts of time. Reactive oxygen
species (ROS), oxidant, and anti-oxidant molecules were measured with biochemical
assays, rt-PCR, and western blot. A urate transport inhibitor and oxidative inhibitors
were used to confirm the effect of exogenous urate.

Results:

All concentrations of exogenous urate stimulated the production of ROS in a
time- and concentration-dependent manner, as well as oxidant molecules, including
hydrogen peroxide (H2O2), nicotinamide adenine dinucleotide phosphate (NADPH)
oxidase, nitric oxide (NO) inducible nitric oxide synthase (iNOS), and these effects,
could be inhibited by oxidant inhibitors. However, anti-oxidant molecules, including
acidic leucine-rich nuclear phosphoprotein-32A (ANP32A), ataxia-telangiectasia mutated
(ATM), heme oxygenase-1 (HO-1), and the transcription factor nuclear factor
erythroid 2 (NF-E2)-related (Nrf2), was decreased by high concentrations of exogenous
urate after prolonged incubation, but not by low to medium concentrations of
exogenous urate. By inhibiting soluble urate trafficking, benzbromarone significantly
suppressed the effect of urate stimulus on the oxidant and anti-oxidant molecules.

Conclusion:

Intracellular soluble urate could regulate chondrocyte redox balance in a
time and concentration-dependent manner, and would be a target for regulating and
protecting chondrocyte function in the early gout stage.
Facial Palsy Induced by Covaxin in Adolescent Female - A Rare Case Report
Authors: Chaudhari Priyanka Jivrambhai , Chawda Uditkumar Bhupeshkumar , Bhad Bhagirath Jayantilal , Mevada Ashvin Vasantlal , Jha Sushilkuamar Gopikant
Published: December 2022

Background:

The world has seen nearly 2 years of a pandemic caused by the SARS-CoV-2
virus, notoriously known as COVID-19. Several vaccines have been approved under Emergency Use
Authorization (EUA) to combat the disease, one of which is Covaxin, an inactivated adjuvant SARSCoV-
2 vaccine that is generally well tolerated and has fewer side effects. However, we recently have
seen a rare case of facial palsy (paralysis) following Covaxin vaccination in an adolescent girl.

Case Presentation:

A 16 years old adolescent girl presented with chief complaints of left side deviation
of mouth with difficulty in closing right eye after 29 days of receiving the first dose of Covaxin,
which was finally diagnosed as a "Covaxin induced facial palsy". Her symptoms were alleviated
with some supportive measures, steroid and antiviral treatment, with full recovery.

Conclusion:

The case depicts facial nerve paralysis following Covaxin use, possibly the first of its
kind. This case illustrates plausible explanation to Covaxin use and occurrence of facial palsy,
however, further studies required to establish causal relationship.
Studies on Montmorillonitic (Bentonite) Clay of Western Kazakhstan as a Therapeutic Mineral Feed Additive for Quails
Authors: Montayeva Nurgul S. , Montayev Sarsenbek A. , Montayeva Aruzhan S.
Published: December 2022

Background:

The paper presents the findings of a broad analytical review of the use of bentonite clays as a mineral feed additive in poultry farming in order to increase productivity and prevent diseases. It has been shown that an important direction in improving the technology of veterinary preventive measures is the introduction of new methods for the prevention and treatment of diseases in quails with the use of drugs with bioactive properties that can have a regulatory effect on the intensity of metabolic processes and enhance the functional activity of organs and body systems. The emphasis is placed on the unique properties of bentonite as high adsorption, catalytic, and ion-exchange activity.

Methods:

Using the comparison method, the authors studied preliminary studies of the chemical and mineralogical composition of the montmorillonite clay of the Pogadaevsky deposit of the West Kazakhstan region. The method of scanning electron microscopy was used to determine the local elemental composition of the provided samples. The mass spectrometry method was used to determine the chemical elemental composition. In addition, the X-ray diffractometry method was used to determine the mineralogical composition.

Results:

According to the results of scientific and experimental research, it was established that the studied clay has a significant sorption activity.

Conclusion:

The first scientific experiments on the effect of bentonite-like (montmorillonite) clay on the egg production of quails showed its significant effectiveness.
Korban Dan/Atau Pelaku: Atribusi Victim Blaming pada Korban Kekerasan Seksual Berbasis Gender di Lingkungan Kampus
Authors: Wahyuni Sri , Nurbayani Siti , Kesumaningsih Ilma , Hargono Dinar
Published: December 2022

Sexual harassment frequently occurs in educational institutions such as colleges. The issue is exposed on the internet or reported directly by the authorized party. However, these reports lead society tendentiously to blame the victim. The victim-blaming phenomenon in sexual harassment cases particularly, when the victim object is female college students effecting them feeling frustrated, and scared, and even their rights as the victim cannot be obtained at all. This form of attribution of victims of violence often spurs the emergence of a victim mentality for victims of the stigma attached to dualism, as victims as well as contributing to the occurrence of violent events that befell them (the perpetrator). These things cause the victims to prefer remaining silent, than to reveal the case that has been going through due to worrying to be blamed. This research aims to figure out how the victim-blaming phenomenon happens to the victim of sexual harassment based on gender in educational institutions to provide policy recommendations to protect the victim and also for the student organization or the college. The method of this research is qualitative descriptive by utilizing triangulation data sources as data validation for the research approach. Data is obtained by documentation, field study, and depth interview with the victim of sexual harassment and policy experts from the college by using purposive sampling. Data analysis is performed together with the collecting data process by using qualitative techniques consisting of data reduction, display data, and conclusion. The result of this study shows that the student organization and college can role to form some preventive efforts on the victim-blaming phenomenon which can be implemented through a program or activity that is carried out online or offline.
Avaliação técnica da substituição do filler calcário por cinza da casca da castanha de caju no concreto autoadensável
Authors: Dias A. R. O. , Amancio F. A. , Cabral A. E. B.
Published: December 2022

O presente trabalho teve por objetivo avaliar a substituição do fíller calcário pela Cinza da Casca da Castanha de Caju (CCCC), nas porcentagens de 10%, 20% e 30% em volume na fabricação de Concretos Autoadensáveis (CAA). No estado fresco foram analisados o espalhamento, caixa-L, funil-V , densidade e teor de ar incorporado. No estado endurecido foi investigado a resistência a compressão aos 3, 7, 28 e 63 dias, ensaio de ultrassom e absorção de agua por capilaridade. Os resultados obtidos demonstraram que no estado fresco, à medida em que se aumenta a substituição de filler calcário por CCCC é necessário uma maior quantidade de aditivo superplastificante para manter as propriedades do CAA. No estado endurecido o teor de 30% de CCCC ficou próximo ao valor de referência, no entanto, esta resistência pode ser devido ao aumento do teor de aditivo superplastificante e não apenas à incorporação de CCCC. Alem disto, a variação do teor de substituição da CCCC não tem infuência na absorção por capilaridade.
Análise de recalques em fundações superficiais do tipo radier plano sobre solo silto-argiloso na região metropolitana de Recife - Brasil
Authors: L.F.A. Lopes  , J.T.R. Oliveira
Published: December 2022

Este trabalho tem como objetivo verificar o comportamento dos recalques de sessenta e quatro edificações assentadas sobre um solo silto-argiloso compostas de fundação do tipo radier plano e superestrutura em paredes de concreto moldadas no local. Foi realizada uma revisão bibliográfica acerca dos movimentos de fundações e seus tipos. Avaliou-se a estabilização do maciço e o desenvolvimento dos recalques no tempo, também fazendo uma comparação entre os valores máximos obtidos em campo e os valores máximos estimados. Foram avaliados recalques diferenciais e as distorções angulares através de uma comparação comos valores limites apresentados pela literatura e valores estimados em projeto. Os recalques das fundações apresentaram valores abaixo do estimado para os valores máximos. As distorções angulares ficaram todas abaixo dos valores estimados e na verificação com a literatura seis das estruturas estavam susceptíveis a apresentar fissuras em alvenaria. A análise final apresentou que os recalques não oferecem risco estrutural à nenhuma das sessenta e quatro edificações e isso se confirma com o fato da maioria delas já estar ocupada e não ter sido verificado nenhum quadro de patologias decorrente de recalques.
Avaliação do grau de homogeneidade do concreto dosado em central e obtido por caminhão betoneira
Authors: S.H.M. Mittri  , G.L. Vieira  , A.A.F. Mendes  , G.C. Guignone
Published: December 2022

Releva-se, a necessidade da execução de concretos homogêneos a fim de garantir a qualidade das estruturas de concreto armado. O mencionado fato torna-se ainda mais relevante, pois as premissas de cálculos de projeto consideram os elementos estruturais contemplando características similares em qualquer seção transversal. Neste contexto, tem-se diretriz expressa na norma de amostragem de concreto fresco, NBR NM 33 (ABNT, 1998), que preconiza a retirada de amostras após a descarga de pelo menos 15% do volume total da betonada e antes da descarga de 85%, para que se possa atestar o grau de homogeneização do concreto. Em contrapartida ao que recomenda a norma, sabe-se que na maioria das obras recolhem-se as amostras de concreto antes do início da concretagem. Este trabalho tem por objetivo verificar o grau de homogeneidade do concreto dosado em central e fornecido por meio de caminhão betoneira. Para efeito, foram realizadas análises em 4 obras distintas, verificando-se o índice de consistência e as propriedades mecânicas dos concretos em duas etapas: coleta no início da concretagem e no intervalo de descarga preconizado pela norma. Pôde-se constatar que não há diferença significativa entre o concreto recolhido no início da concretagem e o concreto recolhido no intervalo recomendado pela norma.
Propriedades de concreto auto-adensável contendo cinzas volantes
Authors: A. Schackow  , C. Effting  , D. Marcon Neto  , D.E. Bonifácio  , I.R. Gomes
Published: December 2022

Self-compacting concrete is a high performance concrete with excellent rheological properties that can be spread in areas of difficult access. Selfcompacting concrete requires a high consumption of cement production, which has a negative effect on the environmental aspect, since the production of cement releases significant amounts of CO2. This study aims analysis the influence of the substitution (20 and 40% by weight) of Portland cement by fly ash on the selfcompacting concrete properties in the fresh state (spreading, workability, passing ability - J-ring test, viscosity - V-funnel test) and hardened (compressive strength).The passing ability was proved more effective to the mixture with 20% of replacement. To the viscosity, control concrete had lower flow time in V-funnel. The compressive strength results at 28 days showed a reduction of 9.5% for concrete with 20% fly ash and 77.0% for concrete with 40% fly ash compared to the control concrete.
Uma heurística para o dimensionamento ótimo de treliças espaciais regulares
Authors: P.F.M. Santana  , C.A.S. Freitas  , V.H.F.B. Sobrinho  , F.S. Duarte  , F.J.P. Almeida
Published: December 2022

Este trabalho apresenta uma heurística computacional para o dimensionamento de estruturas treliçadas espaciais regulares, buscando minimizar uma combinação entre o peso e altura da treliça. Esta combinação é uma média ponderada cujos pesos representam o grau de importância, definido pelo usuário, de cada um destes parâmetros. As treliças são analisadas segundo um modelo linear elástico via Método dos Elementos Finitos. Para serem consideradas viáveis devem atender a restrições estabelecidas em norma específica de estruturas metálicas. Para validação, do programa desenvolvido, foram comparados os resultados daotimização de três estruturas com o programa SAP2000. Assim os resultados diferiram com acréscimos de 0,93% para a flecha máxima, 0,42% para a carga de compressão e 0,45% para a carga de tração. Portanto o método proposto torna-se uma alternativa viável para o dimensionamento otimizado de treliças regulares metálicas tridimensionais.
Automated control systems for civil construction machinery using RTK-GNSS: an implementation review
Authors: J.M. Lopes  , J.L.A. Trabanco
Published: December 2022

The modernization of global navigation satellite systems (GNSS) allowed us to obtain positions in three dimensions with accurate precision. Techniques such as real-time kinematic positioning (RTK) provide precise coordinates in the field. All the progress has contributed to construction works that make use of heavy machinery as a way to integrate these positioning systems and ensure accuracy of performed activities with increased productivity. A brief analysis on the implementation of automated control systems for construction machinery with the use of RTK-GNSS receivers is presented herein, as well as their needs and advantages as to programming and operation. The commonly automated machines (earthworks, compaction and machinery paving) are classified here into three categories based on their peculiarities and ability to integrate the system components.
Avaliação do comportamento de paredes com materiais de absorção sonora eco-eficientes (tradicionais e inovadores)
Authors: M. Pedroso  , J. Brito  , J.D. Silvestre
Published: December 2022

Este artigo apresenta soluções construtivas de paredes actualmente utilizadas na construção de edifícios e que incluem os materiais de absorção sonora mais utilizados a nível Europeu. Apresenta-se, assim, um total de 78 soluções construtivas de paredes, simples eduplas, estudadas ao nível do seu desempenho acústico, energético, bem como económico, permitindo analisar a viabilidade da inclusão de materiais naturais enquanto substitutos dos materiais considerados tradicionais. O desempenho acústico foi estudado através de modelos de cálculo previsional, tendo em consideração as características de cada material constituinte da solução.Ao nível da energia incorporada e dos custos, os resultados apresentados correspondem ao somatório dos valores de cada constituinte. A inclusão de materiais naturais em soluções construtivas, permitiu concluir que existem materiais alternativos que, do ponto de vista do comportamento acústico, da energia incorporada e ainda do custo, são perfeitamente viáveis para substituiros produtos de utilização corrente. Este resultado foi validado para um conjunto significativo e representativo de soluções construtivas de paredes.
Reabilitação energética da envolvente de edifícios: desempenho económico, energético e ambiental de ETICS com ICB ou EPS
Authors: J. Silvestre  , A. Castelo  , J. Silva  , J. Brito  , M. Pinheiro
Published: December 2022

Este estudo apresenta uma comparação entre sistemas de ETICS (Sistema compósito de Isolamento Térmico pelo exterior) utilizando dois materiais de isolamento diferentes: Aglomerado de Cortiça Expandida (ICB) e Poliestireno Expandido (EPS), durante um perío-do de estudo de 50 anos. O balanço do impacto ambiental é dado por Estudos do ciclo de Vida (ACV) “Craddle to Grave” (C2G), com ênfase nas emissões de carbono e na quantidade de energias primárias renovável (PE-Re) e não renovável (PE-NRe) utilizada por estes materi-ais. O balanço energético considera as principais características de isolamentos destes materi-ais, incluindo o desempenho energético da envolvente dos edifícios após a aplicação destes materiais e as correspondentes poupanças energéticas que estes permitem. O balanço final ente o desempenho ambiental e energético inclui uma estimativa C2G da redução das emissões de carbono e da redução do consumo das PE-RE e PE-NRe.
Avaliação da variabilidade das propriedades dos agregados reciclados de RCD
Authors: V. Martins Junior  , N.C.S. Forti  , A.E.P.G. Ávila  , L.L. Pimentel
Published: December 2022

A necessidade de se buscar destinação ambientalmente adequada para os resíduos de construção e demolição (RCD) torna essencial a reciclagem deste material. As características dos agregados produzidos pelo processo de reciclagem afetam o desempenho dos materiais feitos à base de cimento Portland, somado a isso, a qualidade do agregado reciclado é fortemente influenciada pelo processo produtivo. O objetivo deste trabalho é analisar e avaliar através de ferramentas estatísticas, como análise de variância (ANOVA) e teste Scott-Knott a variabilidade das propriedades dos agregados reciclados (AR) miúdos e graúdos produzidos em quatro usinas recicladoras do estado de São Paulo ao longo de um ano. Coletou-se amostras de AR miúdos (Фmax<4,8mm) e graúdos (Фmax 9,5/25mm) em quatro usinas recicladoras do estado de São Paulo, sendo elas: Hortolândia, Limeira, Jundiaí e Várzea Paulista. Efetuou-se três coletas para cada usina, com tempo de espaçamento entre coletas de quatro meses. As propriedades físicas ensaiadas para a caracterização e análise da variabilidade dos agregados foram: modulo de finura, absorção de água, teor de finos e massa específica. Os resultados obtidos dos ensaios realizados indicam que a variabilidade de características de agregados procedentes de diferentes usinas de reciclagem existe. Pode-se dizer que esta variabilidade se dá não apenas pelas diferenças no processo de produção de cada usina como também pela qualidade do entulho recebido em cada planta e a eficácia de sua triagem.
Análise exploratória do modelo de simulação de rodovias de pista simples do VISSIM
Authors: F.A. Silva  , J.E. Bessa Júnior  , A.L. Costa  , A.L.B.N. Cunha  , D.M.C. Velho  , A.F. Andalício
Published: December 2022

A modelagem de rodovias de pista simples tem sido incorporada em simuladores de tráfego. Como a lógica de simulação em rodovias de pista simples teve que se adequar a outros submodelos comportamentais dos simuladores, como o de car-following e o de mudança de faixas, surge a necessidade de avaliar se a modelagem desse tipo de rodovia tem sido realizada adequadamente. Este artigo, portanto, teve como meta realizar essa análise para o VISSIM, devidamente calibrado por meio de dados de campo e com um Algoritmo Genético. Foram analisadas as variações de duas medidas de desempenho, velocidade média de viagem (ATSd) e número de ultrapassagens (NUd), de acordo com a variação das zonas de ultrapassagens proibidas, da porcentagem de veículos pesados e do fluxo de tráfego unidirecional. Não foram observadas grandes diferenças quando foram avaliados os valores de ATSd, ao contrário do que ocorreu com NUd.
Localization of the Japanese brand Tatcha’s website
Authors: Carmona Carla Sofia
Published: December 2022

The more the world becomes globalized the bigger the need to make online content available and understandable to several locales. In this project we aim to localize a native Japanese website to the Portuguese public, implementing several localization techniques. This website is from a famous Japanese cosmetic brand that puts a heavy emphasis on the underlying Japanese culture and tradition used in all of their products. This makes the localization project more challenging due to the fact that it demands special attention to how the source culture shall be recodified. The tools used in this project were a decisive factor in the success of the localization since they allowed the translation of the strings to flow more quickly and easily. In terms of multimedia content localization, external tools were used and special attention was put in how and where the target files were uploaded. In the end we were able to obtain a perfectly localized website to the Portuguese public, opening the Japanese cosmetic market to a brand-new market opportunity.
LyricLearn: um novo recurso para a aprendizagem de línguas
Authors: Sousa Hugo
Published: December 2022

O LyricLearn é uma ferramenta de aprendizagem da língua inglesa direcionada a estudantes portugueses. Este recurso parte da potencialidade da música para cativar os alunos e motivá-los a aprender a língua. O site explora duas dinâmicas de aprendizagem diferentes: a aprendizagem implícita e explícita. A aprendizagem implícita ocorre à medida que o aluno ouve canções inglesas e simultaneamente lê as legendas em inglês e português correspondentes. A aprendizagem explícita ocorre através de atividades didáticas que permitem pôr em prática os conhecimentos adquiridos ao ver os videoclipes.
Interrater Agreement on National Institutes of Health Stroke Scale Between Paramedics and Stroke Physicians: Validation Study for the Digital Training Model in the Paramedic Norwegian Acute Stroke Prehospital Project
Authors: Guterud Mona , Bugge Helge Fagerheim , Røislien Jo , Larsen Karianne , Eriksen Erik , Ingebretsen Svein Håkon , Mikkelsen Martin Lerstang , Kramer-Johansen Jo , Bache Kristi G , Sandset Else Charlotte , Hov Maren Ranhoff
Published: December 2022

Background

Time spent in the prehospital phase of acute stroke care is multifactorial and has an effect on the possibilities for acute treatment. Communication between paramedics and the in-hospital stroke team directly affects time to treatment. A mutual stroke scale such as the National Institutes of Health Stroke Scale (NIHSS) may improve communication quality. The Paramedic Norwegian Acute Stroke Prehospital Project (ParaNASPP) was a stepped-wedge, randomized trial of stroke screening using NIHSS in the ambulance where the intervention was training paramedics in stroke and the NIHSS, with the use of NIHSS made into a mobile app to guide the examination and facilitate communication with the in-hospital stroke team.

Objective

The aim of this study was to validate the digital training model from the ParaNASPP clinical trial.

Methods

In total, 24 paramedics were recruited from Oslo University Hospital in Norway to complete the ParaNASPP training model; 20 exclusive videos with predefined NIHSS scores were recorded; and 4 stroke physicians from Oslo University Hospital were included for reference. Bland-Altman plots with 95% limits of agreement (LoA) were calculated—first comparing paramedics and stroke physicians to the predefined scores and then with each other. The predefined LoA were set to 3 points. To align with clinical practice, NIHSS scores were also dichotomized into 2 categories: from 0-5 (minor stroke) or ≥6 (moderate and major stroke), and agreement was calculated using Cohen κ.

Results

The videos (n=20) had a median (range) NIHSS score of 7 (0-31). The paramedics’ scores were slightly higher than the predefined scores with a mean difference of –0.38 and the LoA ranging from –4.04 to 3.29. The paramedics scored higher than the stroke physicians with a mean difference of –0.39, with the LoA ranging from –4.58 to 3.80. When the NIHSS scores were dichotomized, Cohen κ was 0.89 between the predefined scores and paramedics, 0.92 between the predefined scores and stroke physicians, and 0.81 between the paramedics and stroke physicians, all indicating very good agreement.

Conclusions

The paramedics scored higher than both the predefined scores and stroke physicians’ scores, hence the predefined LoA were not met. However, the width of the LoA was smaller than seen when experienced neurologists are compared. When the NIHSS scores were dichotomized, the paramedics achieved very good agreement with both the predefined scores and stroke physicians’ scores. This study demonstrates the possibilities for the transfer of clinical competence in digital simulation training.
Design Innovation for Engaging and Accessible Digital Aphasia Therapies: Framework Analysis of the iReadMore App Co-Design Process
Authors: Langford Tom , Fleming Victoria , Upton Emily , Doogan Catherine , Leff Alexander , Romano Daniela M
Published: December 2022

Background

iReadMore is a digital therapy for people with acquired reading impairments (known as alexia) caused by brain injury or neurodegeneration. A phase II clinical trial demonstrated the efficacy of the digital therapy research prototype for improving reading speed and accuracy in people with poststroke aphasia (acquired language impairment) and alexia. However, it also highlighted the complexities and barriers to delivering self-managed therapies at home. Therefore, in order to translate the positive study results into real-world benefits, iReadMore required subsequent design innovation. Here, we present qualitative findings from the co-design process as well as the methodology.

Objective

We aimed to present a methodology for inclusive co-design in the redesign of a digital therapy prototype, focusing on elements of accessibility and user engagement. We used framework analysis to explore the themes of the communications and interactions from the co-design process.

Methods

This study included 2 stages. In the first stage, 5 in-person co-design sessions were held with participants living with poststroke aphasia (n=22) and their carers (n=3), and in the second stage, remote one-to-one beta-testing sessions were held with participants with aphasia (n=20) and their carers (n=5) to test and refine the final design. Data collection included video recordings of the co-design sessions in addition to participants’ written notes and drawings. Framework analysis was used to identify themes within the data relevant to the design of digital aphasia therapies in general.

Results

From a qualitative framework analysis of the data generated in the co-design process, 7 key areas of consideration for digital aphasia therapies have been proposed and discussed in context. The themes generated were agency, intuitive design, motivation, personal trajectory, recognizable and relatable content, social and sharing, and widening participation. This study enabled the deployment of the iReadMore app in an accessible and engaging format.

Conclusions

Co-design is a valuable strategy for innovating beyond traditional therapy designs to utilize what is achievable with technology-based therapies in user-centered design. The co-designed iReadMore app has been publicly released for use in the rehabilitation of acquired reading impairments. This paper details the co-design process for the iReadMore therapy app and provides a methodology for how inclusive co-design can be conducted with people with aphasia. The findings of the framework analysis offer insights into design considerations for digital therapies that are important to people living with aphasia.
Evaluating the Possibility of Publication: an Interview Study (Preprint)
Authors: Lei Jianbo
Published: December 2022

BACKGROUND

1

OBJECTIVE

1

METHODS

1

RESULTS

1

CONCLUSIONS

1

CLINICALTRIAL

1
Use of Rapid Antigen Tests to End Isolation in a University Setting: Observational Study (Preprint)
Authors: Zigo Liliana , Wilkinson Alyson , Landry Megan , Castel Amanda D , Vyas Amita , McDonnell Karen , Nagaraj Nitasha Chaudhary , Goldman Lynn R
Published: December 2022

BACKGROUND

COVID-19 isolation recommendations have evolved over the course of the pandemic. Initially, the US Centers for Disease Control and Prevention required 10 days of isolation after a positive test result. In December 2021, this was reduced to a minimum of 5 days with symptom improvement, followed by 5 days of mask wearing. As a result, several institutions of higher education, including the George Washington University, required persons testing positive for COVID-19 to either submit a negative rapid antigen test (RAT) with symptom resolution to leave isolation after 5 days or to maintain a 10-day isolation period in the absence of a negative RAT and the presence of continued symptoms. RATs are tools that can be used both to shorten isolation periods and to ensure that persons testing positive for COVID-19 remain in isolation if infectious.

OBJECTIVE

The purpose of this analysis is to report on the experience of implementing RAT policies, examine the number of days that isolation was reduced via RAT testing, determine the factors that predicted uploading a RAT, and determine RAT positivity percentages to illustrate the utility of using RATs to end isolation.

METHODS

In this study, 880 individuals in COVID-19 isolation at a university in Washington, DC, uploaded 887 RATs between February 21 and April 14, 2022. Daily positivity percentages were calculated, and multiple logistic regression analyses examined the odds of uploading a RAT by campus residential living status (ie, on or off campus), student or employee designation, age, and days in isolation.

RESULTS

A total of 76% (669/880) of individuals in isolation uploaded a RAT during the study period. Overall, 38.6% (342/887) of uploaded RATs were positive. Uploaded RATs were positive 45.6% (118/259) of the time on day 5; 45.4% (55/121) on day 6; 47.1% (99/210) on day 7; and 11.1% (7/63) on day 10 or beyond. Adjusted logistic regression modeling indicated cases living on campus had increased odds of uploading a RAT (odds ratio [OR] 2.54, 95% CI 1.64-3.92), whereas primary student affiliation (OR 0.29, 95% CI 0.12-0.69) and days in isolation (OR 0.45, 95% CI 0.39-0.52) had decreased odds of uploading a RAT. Of the 545 cases with a negative RAT, 477 were cleared prior to day 10 of their isolation due to lack of symptoms and timely submission, resulting in a total of 1547 days of lost productivity saved compared to all being in isolation for 10 days.

CONCLUSIONS

RATs are beneficial, as they can support a decision to release individuals from isolation when they have recovered and maintain isolation for people who may still be infectious. Future isolation policies should be guided by similar protocols and research to reduce the spread of COVID-19 and minimize lost productivity and disruption to individuals’ lives.
Establishment of the predictive model for delayed metabolism of methotrexate in children with acute lymphoblastic leukemia: a retrospective study (Preprint)
Authors: Jian Chang , Chen Siqi , Zhou Yang , Zhang Yang , Li Ziyu , Jian Jie , Wang Tingting , Xiang Tianyu , Wang Xiao , Wang Huilai , Gong Jun
Published: December 2022

BACKGROUND

Methotrexate (MTX) is an effective chemotherapy for acute lymphoblastic leukemia (ALL) in children. However, prolonged exposure to high concentrations of MTX is associated with substantial adverse effects, including individual metabolic variability. Therefore, serum concentrations of MTX should be closely monitored in severe ALL patients to provide timely intervention.

OBJECTIVE

To achieve timely intervention for metabolic delay and personalized treatment by detecting serum methotrexate (MTX) concentration, we used multicenter MTX prescription data to predict the delayed MTX metabolism in children with Acute lymphoid leukemia(ALL) using machine learning (ML).

METHODS

We collected MTX chemotherapy data of 1729 cases. Univariate analysis and least absolute shrinkage and selection operator (LASSO) regression analysis were used to feature screening. Random forest classifier (RFC), eXtreme gradient boosting (XGBoost), adaptive boosting (AdaBoost), and light gradient boosting machine (LightGBM) ML algorithms were applied to construct prediction models. A series of indicators included the area under the receiver operating characteristic curve (AUROC) and the area under the PR curve (AUPR). Shapley Additive exPlanations (SHAP) were used to interpret the prediction models.

RESULTS

Eleven predictors were screened using univariate analysis and LASSO regression analysis, including age, weight, creatinine, uric acid total bilirubin albumin, white blood cell count, hemoglobin, prothrombin time, type of cell morphological classification, and omeprazole comedication. Among the test set, XGBoost had the AUROC of 0.898 (95% CI, 0.860–0.936) and AUPR of 0.752, RFC had the AUROC of 0.841 (95% CI, 0.789–0.893) and AUPR of 0.365, AdaBoost had the AUROC of 0.890 (95% CI, 0.848–0.932) and AUPR of 0.729, LightGBM had the AUROC of 0.900 (95% CI, 0.866–0.935) and AUPR of 0.722.

CONCLUSIONS

The XGBoost algorithm owned the best performance and the model showed accurate discriminatory ability in predicting the delayed metabolism of the MTX.
Predicting Pain in People With Sickle Cell Disease in the Day Hospital Using the Commercial Wearable Apple Watch: Feasibility Study (Preprint)
Authors: Stojancic Rebecca Sofia , Subramaniam Arvind , Vuong Caroline , Utkarsh Kumar , Golbasi Nuran , Fernandez Olivia , Shah Nirmish
Published: December 2022

BACKGROUND

Sickle cell disease (SCD) is a genetic red blood cell disorder associated with severe complications including chronic anemia, stroke, and vaso-occlusive crises (VOCs). VOCs are unpredictable, difficult to treat, and the leading cause of hospitalization. Recent efforts have focused on the use of mobile health technology to develop algorithms to predict pain in people with sickle cell disease. Combining the data collection abilities of a consumer wearable, such as the Apple Watch, and machine learning techniques may help us better understand the pain experience and find trends to predict pain from VOCs.

OBJECTIVE

The aim of this study is to (1) determine the feasibility of using the Apple Watch to predict the pain scores in people with sickle cell disease admitted to the Duke University SCD Day Hospital, referred to as the Day Hospital, and (2) build and evaluate machine learning algorithms to predict the pain scores of VOCs with the Apple Watch.

METHODS

Following approval of the institutional review board, patients with sickle cell disease, older than 18 years, and admitted to Day Hospital for a VOC between July 2021 and September 2021 were approached to participate in the study. Participants were provided with an Apple Watch Series 3, which is to be worn for the duration of their visit. Data collected from the Apple Watch included heart rate, heart rate variability (calculated), and calories. Pain scores and vital signs were collected from the electronic medical record. Data were analyzed using 3 different machine learning models: multinomial logistic regression, gradient boosting, and random forest, and 2 null models, to assess the accuracy of pain scores. The evaluation metrics considered were accuracy (F1-score), area under the receiving operating characteristic curve, and root-mean-square error (RMSE).

RESULTS

We enrolled 20 patients with sickle cell disease, all of whom identified as Black or African American and consisted of 12 (60%) females and 8 (40%) males. There were 14 individuals diagnosed with hemoglobin type SS (70%). The median age of the population was 35.5 (IQR 30-41) years. The median time each individual spent wearing the Apple Watch was 2 hours and 17 minutes and a total of 15,683 data points were collected across the population. All models outperformed the null models, and the best-performing model was the random forest model, which was able to predict the pain scores with an accuracy of 84.5%, and a RMSE of 0.84.

CONCLUSIONS

The strong performance of the model in all metrics validates feasibility and the ability to use data collected from a noninvasive device, the Apple Watch, to predict the pain scores during VOCs. It is a novel and feasible approach and presents a low-cost method that could benefit clinicians and individuals with sickle cell disease in the treatment of VOCs.
Electrochemical Behaviour of Silica Deposited on Stainless Steel by Electrophoretic Deposition
Authors: Putri Suari Ni Made Intan , Ratnasari Delyana , Tulaini Sahara , Widiyastuti W. , Setyawan Heru
Published: December 2022

The purpose of this paper is to evaluate the characteristics of corrosion protection of stainless steel substrates coated with silica by electrophoresis with pulsed direct current (PDC) and constant direct current (CDC) with anodization. Electrophoresis was carried out using silica sol from sodium silicate solution as an electrolyte solution. Stainless steel functioned as an anode and carbon as a cathode with a constant electrode distance of 2 cm. The amplitude, duty cycle, and anodization effect on stainless steel corrosion protection characteristics were evaluated. The samples were characterized by linear polarization and electrochemical impedance spectroscopy (EIS) to see the characteristics of metal corrosion protection and scanning electron microscopy (SEM) analysis to see the morphology of the coating. This study showed that PDC electrophoresis and CDC accompanied by anodization could obtain silica film with good corrosion protection characteristics (high pore resistance and low admittance). Linear polarization results showed that metal corrosion protection behavior was increased by anodization. Similar results were obtained by EIS analysis which showed that pore resistance increased by anodization. The highest pore resistance obtained by the constant current with anodization is 543 ohms, and the lowest admittance is 0.0217. Corrosion protection characteristics are also influenced by the amplitude and duty cycle during electrophoresis. Silica film with a high pore resistance and a low admittance were obtained at a frequency, amplitude, and duty cycle of 80 Hz, 0.5 volts, and 60%, respectively. The silica film produced by pulsed electrophoresis resulted in better coating characteristics than by constant current with anodization, which is seen from the pore resistance value and its admittance.
Characterization of Cellulose Acetate Membrane at Different Thicknesses on Sucrose Concentration by Forward Osmosis
Authors: Idris Aida I. Mohamad , Mustapa Kamal Siti Mazlina , Sulaiman Alifdalino , Omar Rozita , Mohammad Munira
Published: December 2022

Forward osmosis (FO) requires a specific membrane structure for applications like juice concentration. The phase inversion method was used to make cellulose acetate (CA) FO membranes. The solvents used were acetone and 1,4-dioxane. Additives included polyvinylpyrrolidone (PVP), methanol, and maleic acid were used in the preparation of CA membrane, which make it easier to improve a FO membrane's permeability. The performance of fabricated FO membrane and their  morphology were evaluaed with different casting thicknesses of 150, 200, and 250 µm. Experiment works begins with an hour of membrane flux testing, deionized water was used as feed solution and 1 M NaCl as draw solution. The membrane was then used to concentrate 0.5 M sucrose with NaCl for 240 minutes (2 M). Contact angle, porosity, and scanning electron miscroscopy (SEM) were used to characterize membrane properties and morphology. High water flux (2.25 L/m2hr) and high porosity (75.86%) were found at 200 µm casting thickness. Water permeability of sucrose concentration at 200 µm casting thickness had the highest flux (2.39 L/m2hr). The results also show that flux values vary with membrane thickness. All membranes were hydrophilic with contact angles below 90°.  A 200 µm casting thickness produces a membrane with smooth and evenly distributed pores, according to morphology analysis. Structural parameter (S) values had a proportional relationship with the FO membrane thickness, which thinner membrane potentially reduces the internal concentration polarization (ICP).
Analgesic and Antipyretic Effects of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract in White Male Rats
Authors: Subakti Betharia Lorenza Br , Ginting Chrismis Novalinda , Chiuman Linda
Published: December 2022

Red dragon fruit (Hylocereus polyrhizus) is a tropical fruit that is currently cultivated in all tropical parts of the world. It is popular to consume its fruit flesh, while the peel is often thrown away. This red dragon fruit peel (RDFPE) is known to possess lots of phytochemical compounds with multitudes of usage, amongst them as an analgesic and antipyretic. Therefore, the active compounds of RDFPE play an important role in the natural product. This study aims to observe and analyze the analgetic and antipyretic activity possessed by red dragon fruit peel. This study is an in-vivo experiment on 25 white male rats divided into five groups, in which each group receive Na CMC, acetaminophen, and the other three groups will receive three different doses of RDFPE (500 mg/kg, 750 mg/kg, and 1000 mg/kg), respectively. Acetic acid writhing and tail immersion methods were performed to induce inflammation and Brewer’s yeast injection performed induced pyrexia. In the investigation of the acetic acid writhing test, the intervention was administered before induction, and for the tail immersion test, induction was given before and after the intervention was administered. Meanwhile, in brewer’s yeast-induced pyrexia, the rectal temperature was measured before induction, 24 hours after induction, and each hour for five four after the intervention; intervention was administered 24 hours after induction. This study found that RDFPE at the dose of 750 mg/kg and 1000 mg/kg are effective as an analgesic by reducing the average writhing and delaying the tail retraction of the experiment subject and also effective as an antipyretic by reducing the elevated temperature of the experiment subject (p<0.05). This study concludes that RDFPE possesses analgesic and antipyretic activity, especially at the higher dose. Phytochemical compounds such as alkaloids and flavonoids are most likely responsible for this analgesic and antipyretic activity by inhibiting inflammation activity.
Sentiment Analysis and Opinion Mining Applied to Scientific Paper Reviews
Authors: Tiwatane Tanishka Balkrishna , Zampalkar Vrushali Balaji , Bhavsar Gauri Sunil , Bachute Sonali Rajendra
Published: December 2022

Abstract: Sentiment analysis and opinion mining is an area that has experienced considerable growth over the last decade.Todo this, natural language techniques and machine learning algorithms are used. This research attempts to determine the feelings, opinions, emotions, among other things, of people on something. A hybrid approach that combines an unsupervised machine learning algorithm with techniques from natural lan- guage processing is proposed to analyze reviews. The first aimof this analysis is to automatically determine the orientation of a review.This article discusses the problem of extracting sentiment and opinions from a collection of reviews on scientific articles conducted under an international conference on computing in northern Chile.
Solar Panel Automated Cleaning Using Water Re-Capture and Re-Circulation System
Authors: Morawala Khevan
Published: December 2022

Abstract: Sun photovoltaic (SPV) module energy output is closely correlated with solar accessible irradiance, spectral content, and other factors including environmental and climatic factors. It is normal for dust from the outside environment to collect on solar photovoltaic (PV) system panels. Physical factors like rain, dirt, dust, snow, etc. can lower a solar panel's overall efficiency. So maintaining a clean solar panel is crucial. The performance of solar panels can be negatively impacted by collected dust, according to research, however, the results were not measured. This study's goal was to investigate how dust build-up affects the efficiency of solar PV panels. To test the electrical output and efficiency of solar panels, experiments were carried out utilizing dust particles on solar panels with a constant-power light source. The efficiency and resultant electrical power generated revealed it. According to the study, the effectiveness of a photovoltaic solar panel might be reduced by up to 30% by dust build-up on its surface. Therefore, it is crucial to clean the solar panel of any dust. We may clean the solar panels and improve their effectiveness by using the wiper on the water pump's base.
Efeito do tratamento com equipe multiprofissional na pressão arterial em mulheres obesas: uma coorte retrospectiva
Authors: Silva Maria de Lourdes Lima de Souza e , Silva Julia Menezes da , Schleu Minna Ferrari
Published: December 2022

A hipertensão arterial sistêmica constitui um grande problema de saúde pública, devido ao impacto na saúde das pessoas portadoras. Sendo assim, valores pressóricos elevados podem acarretar complicações importantes para o indivíduo. Faz-se necessário, portanto, o controle adequado dos níveis pressóricos e a intervenção multiprofissional tem sido bastante promissora nesse sentido. Este é um estudo observacional, coorte retrospectiva, cujo objetivo é avaliar a prevalência da hipertensão arterial e o efeito do tratamento com equipe multiprofissional nas medidas de pressão arterial em mulheres obesas. Foi realizada análise de um banco de dados preexistente, por meio do programa Statistical Package for the Social Sciences, versão 25. Peso, idade, índice de massa corporal, circunferência abdominal, níveis e controle pressóricos, bem como perfil glicêmico e lipídico, foram as principais variáveis analisadas no primeiro e no último atendimento, com intervalo mínimo de um ano. A prevalência de hipertensão arterial, no primeiro atendimento, foi de 65,2%. No entanto, 15,1% das hipertensas estavam controladas. O tempo de acompanhamento foi, em geral, de seis (4,0 – 9,0) anos. No fim do acompanhamento, a prevalência de hipertensão aumentou para 70,9%. A taxa de controle subiu para 41,5%, um incremento, portanto, de 30,4% de hipertensas controladas. As hipertensas apresentaram maior prevalência de diabetes mellitus e síndrome metabólica. O grupo obteve melhora nos níveis pressóricos. Inclusive, a quantidade de hipertensas controladas se elevou. No entanto, a prevalência de diabetes mellitus e síndrome metabólica foi maior nas hipertensas. Sendo assim, novas estratégias precisam ser adotadas de modo a melhorar a adesão terapêutica das pacientes.