bluuebunny/crossref_metadata_2025 huggingface dataset:
PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance
Authors: Feng Chenchen , Li Yuqing , Li Kunping , Lyu Yinfeng , Zhu Wenhui , Jiang Haowen , Wen Hui
Published: September 2021

Background

Kinases play critical role in clear-cell renal cell carcinoma (ccRCC). We aim to exploit novel kinase that is both protumorigenic and drugable in ccRCC.

Methods

Reproduction of public datasets with validation using microarray was performed to identify candidate gene. Functionality was studied using multi-omics with validation in vitro and in vivo.

Results

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4) was differentially expressed showing significantly higher expression in tumor than in normal kidney. PFKFB4 overexpression was associated with advanced tumor grade, stage and worsened prognosis. PFKFB4-knockdown significantly impaired fitness in cell proliferation, migration and wound healing. Despite being recurrently deleted on 3p, PFKFN4 mRNA remained actively transcribed by HIF1α. Metabolomics showed overexpressed PFKFB4 showed enriched metabolites in pentose phosphate pathway (PPP). Phosphoproteomics and immunoprecipitation showed PFKFB4 also phosphorylated NCOA3 which interacted with FBP1 to counteract overactive PPP flux, forming a regulatory loop. PFKFB4-knockdown overcame resistance to Sunitinib in vitro and in vivo both in xenograft and tail-vein injection murine models.

Conclusion

We concluded PFKFB4 was associated with PPP activity and the fine-tuning of which was mediated by its phosphorylation of NCOA3. Targeting PFKFB4 held promise to combat resistance to Sunitinib.
Hypertrophic cardiomyopathy in infant newborns of diabetic mother: a heterogeneous condition, the importance of anamnesis, physical examination and follow-up
Authors: Codazzi Alessia Claudia , Ippolito Rosario , Novara Cecilia , Tondina Enrico , Cerbo Rosa Maria , Tzialla Chryssoula
Published: September 2021

Background

Hypertrophic cardiomyopathy (HCM) in neonates is a rare and heterogeneous disorder. HCM accounts for 25 to 40% of all pediatric cardiomyopathy cases and the highest incidence in pediatric population is reported in children < 1 year.

Case presentation

we report two clinical cases of neonates, born to mothers respectively with a pre-pregnancy insulin-dependent diabetic mellitus type 2 and a suspected diabetes, with inadequate prenatal glycemic control for the first and underestimated glycemic control for the second case, with a different evolution.

In the first case, a slow evidence of improvement of the HCM was observed, persuading us to the diagnosis of a diabetes-related HCM; In the second case the progressive worsening of the HCM during follow-up in association with further investigations, resulted in the diagnosis of Pompe disease.

Conclusions

Hypertrophic cardiomyopathy in newborns can be the clinical expression of different underlying disorders. We aim to show the importance both to reassess maternal and family history and critically evaluate the physical examination in order to address the correct differential diagnosis. Furthermore it is important to continue a regular cardiologic follow-up for this pathology with neonatal onset to prevent a poor prognosis.
The endemic Helicobacter pylori population in Southern Vietnam has both South East Asian and European origins
Authors: Nguyen Trang Hoa , Ho Trang Thi My , Nguyen-Hoang Thien-Phuc , Qumar Shamsul , Pham Thuc Tran Dang , Bui Quy Nhuan , Bulach Dieter , Nguyen Thuy-Vy , Rahman Motiur
Published: September 2021

Background

The burden of Helicobacter pylori-induced gastric cancer varies based on predominant H. pylori population in various geographical regions. Vietnam is a high H. pylori burden country with the highest age-standardized incidence rate of gastric cancer (16.3 cases/100,000 for both sexes) in Southeast Asia, despite this data on the H. pylori population is scanty. We examined the global context of the endemic H. pylori population in Vietnam and present a contextual and comparative genomics analysis of 83 H. pylori isolates from patients in Vietnam.

Results

There are at least two major H. pylori populations are circulating in symptomatic Vietnamese patients. The majority of the isolates (~ 80%, 66/83) belong to the hspEastAsia and the remaining belong to hpEurope population (~ 20%, 17/83). In total, 66 isolates (66/83) were cagA positive, 64 were hspEastAsia isolates and two were hpEurope isolates. Examination of the second repeat region revealed that most of the cagA genes were ABD type (63/66; 61 were hspEastAsia isolates and two were hpEurope isolates). The remaining three isolates (all from hspEastAsia isolates) were ABC or ABCC types. We also detected that 4.5% (3/66) cagA gene from hspEastAsia isolates contained EPIYA-like sequences, ESIYA at EPIYA-B segments. Analysis of the vacA allelic type revealed 98.8% (82/83) and 41% (34/83) of the strains harboured the s1 and m1 allelic variant, respectively; 34/83 carried both s1m1 alleles. The most frequent genotypes among the cagA positive isolates were vacA s1m1/cagA + and vacA s1m2/cagA + , accounting for 51.5% (34/66) and 48.5% (32/66) of the isolates, respectively.

Conclusions

There are two predominant lineages of H. pylori circulating in Vietnam; most of the isolates belong to the hspEastAsia population. The hpEurope population is further divided into two smaller clusters.
Reporting quality evaluation of the stroke clinical practice guidelines: a systematic review
Authors: Lu Shuya , Luo Xufei , Ni Xiaojia , Li Haoxuan , Meng Miaomiao , Cai Yefeng , Liu Yunlan , Ren Mengjuan , Sun Yanrui , Chen Yaolong
Published: September 2021

Objectives

To analyze the effectiveness and quality of stroke clinical practice guidelines (CPGs) published in recent years in order to guide future guideline developers to develop better guidelines.

Participants

No patient involved

Method

PubMed, China Biology Medicine (CBM), Wanfang, CNKI, and CPG-relevant websites were searched from January 2015 to December 2019 by two researchers independently. The RIGHT (Reporting Items for Practice Guidelines in Healthcare) checklist was used to assess the reporting quality in terms of domains and items. Then, a subgroup analysis of the results was performed.

Primary and secondary outcome measures

RIGHT checklist reporting rate

Results

A total of 66 CPGs were included. Twice as many CPGs were published internationally as were published in China. More than half were updated. Most CPGs are published in journals, developed by societies or associations, and were evidence-based grading. The average reporting rate for all included CPGs was 47.6%. Basic information got the highest (71.7% ± 19.7%) reporting rate, while review and quality assurance got the lowest (22.0% ± 24.6%). Then, a cluster analysis between countries, publishing channels, and institutions was performed. There were no statistically significant differences in the reporting quality on the CPGs between publishing countries (China vs. international), publishing channels (journals vs. websites), and institutions (associations vs. non-associations).

Conclusions

Current stroke CPGs reports are of low quality. We recommend that guideline developers improve the quality of reporting of key information and improve the management of conflicts of interest. We recommend that guideline developers consider the RIGHT checklist as an important tool for guideline development.

Trial registration

10.17605/OSF.IO/PBWUX.
A formulation of Clausena anisata (Willd.) Hook. f. Ex Benth and Cassia sieberiana DC. alleviates the symptoms associated with osteoarthritis: a single-blind, randomised controlled trial of a traditional Ghanaian remedy
Authors: Thomford Kwesi Prah , Yorke Joseph , Thomford Ama Kyeraa , Amponsah Isaac Kingsley
Published: September 2021

Background

Clinical validation of herbal medicinal products is important for their widespread acceptance and application. In this single-blind, randomised controlled trial, a traditional Ghanaian herbal medicine formulation with Clausena anisata (Willd.) Hook. f. ex Benth and Cassia sieberiana DC. as ingredients was evaluated for its safety and effectiveness in the management of patients with osteoarthritis. The formulation for the purposes of this study was labelled with the code GC-500.

Methods

A total of 57 participants were randomly assigned to receive either this herbal remedy, GC-500, or the control treatment of diclofenac. Subjects were then followed up for a period of 8 weeks using a modified Graded Chronic Pain Scale (GCPS) for their efficacy assessments. The control treatment comprised 13 subjects and the GC-500 group 44 subjects.

Results

Upon completion of the study, 28 (63.63%) subjects in the GC-500 group attained the primary outcome, (GCPS of Grade 0) compared to 5 (38.46%) subjects in the control group. Improvement in disease indicators such as characteristic pain intensity, disability score and disability days was comparable between the GC-500 and diclofenac. Intensity of pain reduced after 8 weeks of treatment; disability score and disability days also declined indicating an improvement in the quality of life of subjects. GC-500 was also shown to be safe for human use.

Conclusion

The herbal medicine formulation GC-500, provides a credible treatment option for managing the pain associated with osteoarthritis.

Trial registration

This study was retrospectively registered with the Pan-African Trial registry with a Trial ID: PACTR201909643671755 on 25th September, 2019 at https://pactr.samrc.ac.za/Search.aspx
Individual versus general structured feedback to improve agreement in grant peer review: a randomized controlled trial
Authors: Hesselberg Jan-Ole , Fostervold Knut Inge , Ulleberg Pål , Svege Ida
Published: September 2021

Background

Vast sums are distributed based on grant peer review, but studies show that interrater reliability is often low. In this study, we tested the effect of receiving two short individual feedback reports compared to one short general feedback report on the agreement between reviewers.

Methods

A total of 42 reviewers at the Norwegian Foundation Dam were randomly assigned to receive either a general feedback report or an individual feedback report. The general feedback group received one report before the start of the reviews that contained general information about the previous call in which the reviewers participated. In the individual feedback group, the reviewers received two reports, one before the review period (based on the previous call) and one during the period (based on the current call). In the individual feedback group, the reviewers were presented with detailed information on their scoring compared with the review committee as a whole, both before and during the review period. The main outcomes were the proportion of agreement in the eligibility assessment and the average difference in scores between pairs of reviewers assessing the same proposal. The outcomes were measured in 2017 and after the feedback was provided in 2018.

Results

A total of 2398 paired reviews were included in the analysis. There was a significant difference between the two groups in the proportion of absolute agreement on whether the proposal was eligible for the funding programme, with the general feedback group demonstrating a higher rate of agreement. There was no difference between the two groups in terms of the average score difference. However, the agreement regarding the proposal score remained critically low for both groups.

Conclusions

We did not observe changes in proposal score agreement between 2017 and 2018 in reviewers receiving different feedback. The low levels of agreement remain a major concern in grant peer review, and research to identify contributing factors as well as the development and testing of interventions to increase agreement rates are still needed.

Trial registration

The study was preregistered at OSF.io/n4fq3.
Are doctors protected enough during COVID-19 in South Asia?
Authors: Jatoi Nadia Nazir , Ahmad Saniya , Sajid Emad ud-din , Yasmin Farah , Asghar Muhammad Sohaib , Farhan Syed Ali , Sayeed Bushra Zafar , Marufi Momina Mariam , Fatima Kaneez , Mahmood Syed Faisal
Published: September 2021

Background

The highly contagious nature of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) places physicians in South Asia at high risk of contracting the infection. Accordingly, we conducted this study to provide an updated account of physician deaths in South Asia during the COVID-19 pandemic and to analyze and compare the different characteristics associated with physician mortality amongst the countries of the region.

Methods

We performed a cross-sectional study by using published news reports on the websites of news agencies from 9 selected countries in South Asia. Our study included only those physicians and doctors who died after contracting COVID-19 from their respective workplaces. All available data about the country of origin, type of, sex, age, medical or surgical specialty, and date of death were included.

Results

The total number of physician deaths reported due to COVID-19 in our study was 170, with half (87/170, 51%) of the deaths reported from Iran. Male physician deaths were reported to be 145 (145/170 = 85%). Internal Medicine (58.43%) was the most severely affected sub-specialty. The highest physician mortality rate in the general population recorded in Afghanistan (27/1000 deaths). General physicians from India [OR = 11.00(95% CI = 1.06–114.08), p = 0.045] and public sector medical practitioners from Pakistan [aOR = 4.52 (95% CI = 1.18–17.33), p = 0.028] were showing significant mortality when compared with other regions in multivariate logistic regression.

Conclusion

An increased number of physician deaths, owing to COVID-19, has been shown in South Asia. This could be due to decreased personal protective equipment and the poor health care management systems of the countries in the region to combat the pandemic. Future studies should provide detailed information of characteristics associated with physician mortalities along with the main complications arising due to the virus.
Local characterization of the COVID-19 response: the case of a lockdown in Lusaka, Zambia
Authors: Muzyamba Choolwe
Published: September 2021

Background

The onset of the COVID-19 pandemic has sparked heated debate among scholars on the relevance of lockdowns. There are those in favor of the lockdown and others who are critical of it. However, despite the increased interest in understanding the relevance of lockdowns, there still has not been much focus on its relevance in countries like Zambia. Thus, with the help of the Social Representation Theory (SRT), we set out to explore and document the local characterization of the lockdown by residents of Lusaka, Zambia.

Methods

We recruited our participants through convenient and purposive sampling techniques. This was done through the use of the ZAMTEL public phone records. Initial contact was made to potential participants, and they were asked of their availability and willingness to participate in the interview. Upon agreeing to participate, they were included in the sample. A total of 68 people were selected to take part in this study. Their age ranged from 20 to 76 years old. 33 of them were male and 35 females. After this, we conducted interviews with the 68 participants. Due to COVID-19 restrictions, our interviews were conducted via telephone in conformity with the recommendations from the IRB in Lusaka and the advice of the ministry of health. We anonymized the demographic characteristics and responses from our participants. Later, thematic analysis was used to analyze the data.

Results

The lockdown was on one hand lauded for slowing down the incidence rates, preventing fatalities, and protecting the healthcare system from collapse. On the other hand, it was criticized for exacerbating poverty levels, unemployment rates, increasing the rate of mental health problems, aiding gender-based violence, and intensifying political repression and corruption. The results speak to the complexity in the characterization of the lockdown as a response to COVID-19 in Lusaka, Zambia. This observation demonstrates the folly of viewing, applying and characterizing the COVID-19 lockdown as a ‘one-size-fits-all’ approach in Lusaka, Zambia.

Conclusion

Rather than establishing the lockdown as an incontestable good, as it is depicted by some scholars or as useless by its critics, our findings instead demonstrate the diversity and complexity in how it is locally viewed by Lusaka residents. The study provides grounds for caution on simplistic and binary characterization of lockdowns. It indicates the need for careful dialog between the designers of lockdowns and citizens in order to tailor such interventions to local realities in context-specific ways. It also shows that though the development of such interventions, all the various and complex elements it embodies must be taken into account in order to realize optimum outcomes.
Matrix metalloproteinase-1 as a non-invasive biomarker to assess liver fibrosis in children with chronic liver disease
Authors: Behairy Ola Galal , El-Bakry Mohamed Mostafa , Mansour Amira Ibrahim , Abdelrahman Amira M. N. , Emam Ghada Mansour
Published: September 2021

Background

Abnormal extracellular matrix (ECM) turnover is linked to liver fibrosis as it reflects an imbalance between repair and progressive substitution of the liver parenchyma by scar tissue. Matrix metalloproteinases (MMPs) are the primary enzymes involved in ECM breakdown. So, this study aims to measure the value of serum matrix metalloproteinase-1 (MMP-1) in children with chronic liver diseases (CLD) in comparison with liver biopsy and serum biomarkers. A hundred twenty children with chronic liver diseases and sixty healthy children as a control group were included in this study. Both groups were evaluated via medical history, clinical, radiological, laboratory investigations, and serum MMP-1 level was measured by ELISA. Liver biopsy was performed for studied patients only.

Results

The mean MMP-1 was 15.2 ± 5.1 ng/ml in children with CLD, and 64.7 ± 27.4 ng/ml in the control group. MMP-1 was statistically lower in the children with CLD than controls (p < 0.001). The mean ± SD of aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 (FIB-4) scores in all studied cases showed a significant trend of increase with progressive fibrosis stage evident with histological METAVIR scoring system, while serum MMP-1 concentration was decreased significantly with increasing the degree of fibrosis in CLD group (P 0.001). Serum MMP-1 was indirectly correlated with serum biomarkers and the degree of fibrosis in patients.

Conclusions

MMP-1 is a useful non-invasive marker for detection of the stage of liver fibrosis in children with chronic liver diseases.
Magnitude and Temporal Trend of the Chronic Myeloid Leukemia: On the Basis of the Global Burden of Disease Study 2019
Authors: Hu Yuefen , Li Qizhao , Hou Ming , Peng Jun , Yang Xiaorong , Xu Shuqian
Published: September 2021

PURPOSE

To map the magnitudes and temporal trends of chronic myeloid leukemia (CML) along with its attributable risk factors, providing the essential foundation for targeted public policies at the national, regional, and global levels.

MATERIALS AND METHODS

We retrieved annual data on CML burden in 204 countries and regions from the Global Burden of Disease Study 2019 in 1990-2019. The estimated annual percentage change (EAPC) was calculated to quantify the temporal trends of CML burden by region, sex, and age group.

RESULTS

Globally, the age-standardized incidence rate of CML declined weakly over the past few years (EAPC: −1.04), but the number of incident cases increased by 54.1% to 65.8 × 103 in 2019. By contrast, a dramatic drop in death and disability-adjusted life years (DALYs) rate (EAPCs: −2.55; −2.69) led to a reduction in deaths and DALYs, especially in high-income regions. In 2019, the highest age-standardized death rate was observed in Ethiopia (1.89 per 100,000). The death rate of CML was pronounced among the population age above 70 years. DALYs of CML worldwide were primarily attributable to smoking (12.2%), high body mass index (5.0%), occupational exposure to benzene (0.9%), and occupational exposure to formaldehyde (0.3%) in 2019.

CONCLUSION

Although the mortality rate of CML has decreased significantly, the management of patients with CML cannot be neglected, especially in elders and developing regions.
Eye morphogenesis in the blind Mexican cavefish
Authors: Devos Lucie , Agnès François , Edouard Joanne , Simon Victor , Legendre Laurent , El Khallouki Naima , Barbachou Sosthène , Sohm Frédéric , Rétaux Sylvie
Published: September 2021

The morphogenesis of the vertebrate eye consists of a complex choreography of cell movements, tightly coupled to axial regionalization and cell type specification processes. Disturbances in these events can lead to developmental defects and blindness. Here, we have deciphered the sequence of defective events leading to coloboma in the embryonic eye of the blind cavefish of the species Astyanax mexicanus. Using comparative live imaging on targeted enhancer-trap Zic1:hsp70:GFP reporter lines of both the normal, river-dwelling morph and the cave morph of the species, we identified defects in migratory cell behaviours during evagination that participate in the reduced optic vesicle size in cavefish, without proliferation defect. Further, impaired optic cup invagination shifts the relative position of the lens and contributes to coloboma in cavefish. Based on these results, we propose a developmental scenario to explain the cavefish phenotype and discuss developmental constraints to morphological evolution. The cavefish eye appears as an outstanding natural mutant model to study molecular and cellular processes involved in optic region morphogenesis.
Alcohol-Substituted Vinyl Polymers for Stockpiling Hydrogen
Authors: Oka Kouki , Kataoka Miho , Kaiwa Yusuke , Oyaizu Kenichi
Published: September 2021

Hydrogen has a high energy density and produces only water during combustion; consequently, it has attracted considerable attention as a next-generation sustainable energy source. To be used on a daily basis, hydrogen-storage materials need to stockpile hydrogen safely and to release it using only small amounts of energy. Chemically bonded hydrogen stored in a polymer is highly safe, enabling hydrogen to be stored under ambient conditions in a non-volatile, non-toxic, and non-flammable manner. Herein, we report the dehydrogenation reactions of alcohol-substituted vinyl polymers at mild temperatures. Poly(allyl alcohol) was dehydrogenated at 65–95 °C in the presence of an iridium complex catalyst to produce poly(acrylic acid) due to the extremely low activation energy (10 kJ/mol) associated with the catalyst-specific cycle. Poly(allyl alcohol) exhibits a hydrogen-storage density of 6.8 wt% by releasing two equivalents of hydrogen gas, which demonstrates that alcohol-substituted vinyl polymers can be used to stockpile hydrogen and release it under mild conditions.
Chiral Discrimination of Dansylated Alanine Methyl Ester on a Modified Clay Surface: Vibrational Circular Dichroism Approach
Authors: Yamagishi Akihiko , Takimoto Kazuyoshi , Tamura Kenji , Sato Fumi , Sato Hisako
Published: September 2021

Baseline separation was achieved when dansylated alanine methyl ester (denoted by dan-ala-me) was eluted with methanol on an HPLC (high performance liquid chromatography) column (5 cm × 4 mm (i.d.)) packed with an ion-exchange adduct of synthetic hectorite and Δ-[Ru(phen)3]2+ (phen = 1, 10-phenanthroline). In order to unravel the separation mechanisms, the adsorption state of R- or S-dan-ala-me on a modified clay surface was investigated by means of solid-state vibrational circular dichroism spectroscopy. It was deduced that a dan-ala-me molecule changed its conformation, depending on the chirality relation to a co-adsorbed Ru(II) complex. The theoretical simulation of an association between a Ru(II) complex and a dan-ala-me molecule supported the conclusion.
Effect of Thiophene π-Conjugation Spacers on the Performance of Photosensitized Dyes Having Trifluoromethylthiazole-5-carboxylic Acid as an Acceptor-anchor Moiety
Authors: Iwata Satoru , Ohtuji Mamoru , Kobayashi Shintaro , Aoyama Misa , Tanaka Kiyoshi
Published: September 2021

Novel photosensitized trifluoromethylthiazole-5-carboxylic acid dyes having different numbers of thiophene π-conjugation spacers (MCL15, MCL17, and MCL19) and a benzodithiophene spacer with long alkyl side chains (MCL40) are synthesized. The resulting extension of the π-conjugation system leads to redshift in the absorption wavelength. The long alkyl side chains of benzodithiophene cause a dispersed aggregation effect; therefore, the co-adsorbent becomes unnecessary for dye-sensitized solar cell (DSSC) fabrication. The DSSCs fabricated using these dyes exhibit increased conversion efficiency compared with those without a thiophene unit (MCL05).
Identifying priority interventions for stroke in Ireland through stakeholder engagement to inform population-based modelling: a mixed methods protocol
Authors: Sexton Eithne , Hickey Anne , Williams David J. , Horgan F. , Byrne Elaine , Macey Chris , Cuffe Padraic , Timmons Suzanne , Collins Rónán , Bennett K.
Published: September 2021

Introduction

Improvements in stroke survival have resulted in increasing numbers of people living with stroke, and with a rapidly evolving evidence-base for stroke prevention and management, there is a need for robust data and evidence to inform future policy decision-making. Population-based modelling and economic evaluation of alternative policy options is a useful tool to support decision making. However, this process must be aligned to key stakeholder priorities. The aim of the proposed research is to engage with stakeholders in Ireland to identify their priorities for the development of stroke prevention and management strategies and policies.

Methods

The design is iterative, based on mixed methods. Phase 1 involves a qualitative approach for initial priority gathering, based on an open-ended online survey (target sample: 100-120) and interviews (target sample: 34-40). Stakeholders will include: 1) stroke survivors and family member/main carers, 2) healthcare professionals (HCPs) providing stroke care and 3) people working in stroke research, policy and advocacy. These data will be analysed qualitatively, with the aim of identifying a long-list of specific interventions.  Phase 2 involves an interim priority setting exercise, based on a quantitative online survey. Participants will be asked to rank the interventions on the initial long-list.  These rankings will be used to inform a final priority-setting workshop (Phase 3), where a small stakeholder group will decide on the final set of priorities.

Discussion

The rich and detailed quantitative and qualitative data, based on the views of diverse stakeholders, will be directly relevant to policy makers and service planners involved in developing and improving stroke care in Ireland. The information provided will also be essential to inform the Scenario and Intervention Modelling in Ireland for Stroke (SIMI-Stroke) project, a population-based economic and epidemiological modelling study aimed at identifying cost-effective interventions for stroke across the prevention, acute and post-acute care continuum.
Proposal for an HiTOP-based evaluation scale of traits of the Paranoid Personality Disorder
Authors: Machado Gisele , Carvalho Lucas
Published: September 2021

Aim of the study

This study aimed to operationalize a version of the Dimensional Clinical Personality Inventory 2 (IDCP-2) for the screening of typical traits of the Paranoid personality disorder (PPD) from the perspective of the HiTOP, as well as investigate its internal and external validity.

Subject or material and methods

We selected IDCP-2 factors that appropriately represented PPD traits according to the HiTOP. We created new items for a Rudeness factor. The participants were 454 Brazilian adults (aged 18-70 years). We administered the following scales: IDCP-PPD, PID-5, and CAT-PD-SV.

Results

We found a one higher-order factor structure for the IDCP-PPD The factors that composed this higher-order factor reflect traits from both HiTOP spectra witch PPD is represented, Thought disorder and Antagonistic externalizing. The expected correlations between IDCP-PPD factors and external measures were observed. Groups comparison indicated people with high levels of pathological traits in the external measures showing higher means in the IDCP-PPD scores in comparison to people with lower means in these measures.

Discussion

The factors of the IDCP-PPD demonstrated a good capacity for the assessment of PPD traits.

Conclusions

The findings of our study indicate the IDCP-PPD scale as a useful tool for operationalizing HiTOP for clinical practice. Future studies should test our findings in patients with a PPD diagnosis.
Clinical and psychological characteristics and targets for psychotherapy at atopic dermatitis patients
Authors: Korotkova Inga , Klibson Sergei , Gulordava Maya , Trąbczyński Piotr
Published: September 2021

Aim of the study

The aim of this study was to evaluate levels of anxiety and depression in patients with atopic dermatitis (AD), leading behavioral strategies for coping with stress and their correlation with the severity of dermatological symptoms in patients with AD, as well as the determination of psychotherapeutic targets for improving medical and mental health care for patients with AD.

Subject or material and methods

56 patients with atopic dermatitis and 60 healthy individuals in the control group were examined using the Beck Depression Inventory scale, the State-Trait Anxiety Inventory by C.D. Spielberger, The Coping Strategy Indicator by J.H. Amirkhan and projective technique the Sentence Completion Test. Dermatological assessment was performed using The SCORAD Index.

Results

The AD patients significantly more often turned to “Avoidance strategy” rather than healthy subjects. Unlike healthy patients, those with AD used “Seeking social support” and “Problem solving” as coping techniques considerably less. Dermatosis severity positively correlated with the “Avoidance strategy”, state-trait anxiety scores and severity of depressive symptoms. Retrospective treatment success had a positive impact on reduction of depressive symptoms. Sacks and Levy’s method allowed to discover disturbance in relationships in patients with AD.

Discussion

The AD patients displayed significant difficulties that require psychotherapeutic correction within relations with the opposite sex (36%), with father (29%), guilt (39%) and regrets of untapped opportunities (43%).

Conclusions

The influence of AD on patients’ psychological state determines the necessity of psychological intervention including antianxiety therapy and correction of maladaptive behavioral strategies, as well as attitudes towards person’s relations with family, interpersonal communication and self-perception.
A unique case of neurofibromatosis 1 (NF1) with Cotard syndrome – A case report
Authors: Nemlekar Saumitra , Bardolia Dhruv , Jaganiya Urvish , Mehta Ritambhara , Dave Kamlesh
Published: September 2021

Neurofibromatosis type 1 is a neuro-cutaneous autosomal dominant disorder that is often associated with various psychiatric disorders. Cotard syndrome is a rare neuropsychiatric disorder seen in a variety of neurological and psychological illnesses. The complex course of the neurofibromatosis predisposes the individual towards higher physical and psychiatric morbidity. Here we present a case of Cotard syndrome in a patient with neurofibromatosis. The patient was brought with an alleged history of self-harm and pervasive sadness of mood; a diagnosis of recurrent depressive disorder current episode severe with psychotic features was made. Patient was treated with oral psychotropic agents and responded well to the treatment.
The Effects Of Breast Reductıon Operatıon On Patıents' Mood And Sexual Lıfe
Authors: ALTUNTAS MAHMUT , Uyar ilker , Guncu Hatice
Published: September 2021

Aim of the study

Breast hypertrophy is a condition that can negatively affect the quality of life of women in physical, psychological and sexual aspects. In this study, the effects of breast reduction operation on the psychological and sexual life of the patients in the postoperative period were investigated.

Subject or material and methods

31 patients who underwent breast reduction surgery were included in the study. The patients were evaluated preoperatively and 6 months after surgery. Rosenberg Self-Esteem Scale and Beck Depression Scale were used for psychological evaluation. The Arizona Sexual Experiences Scale was used to evaluate sexual functions, as well.

Results

The average age of the patients was 40.4 and the average BMI was 30.6 kg/m2. The mean scores of Rosenberg Self-Esteem Scale before and after surgery was 1.36 ± 0.94 and 1.02 ± 0.63 (p <0.05). The mean scores of Beck Depression Scale was 14.41±10.11 and 10.35 ± 10.11 (p <0.05), respectively. When the Arizona Sexual Experiences Scale was examined, a statistically significant positive effect was observed in all subgroups compared to the preoperative period.

Discussion

After breast reduction surgery, patients have a very high level of satisfaction physically . There are some studies showing that breast reduction surgery has a positive effect on women, especially psychologically, but very limited research has been done on sexual function.

Conclusions

This study showed that breast reduction surgery increases self-esteem and provides a positive effect on emotional state. At the same time, it has been found that it has a positive effect on sexual functions and sexual life.
Seniors in the 21st century: social, medical and psychological support
Authors: Cyranka Katarzyna , Żukiewicz Arkadiusz , Baran Agnieszka
Published: September 2021

The subject of the analysis addresses seniors. Social, medical and psychological support can be classified as particularly important considering problems seniors face in their everyday life. This implies the need to narrow down the field of analysis to those aspects that the authors are able to responsibly undertake based on their professional experiences and education. Hence, the idea of this article is to explain and justify the need to develop tridisciplinary cooperation: sociology, medicine and psychology. The analysis of issues related to supporting seniors shows also the need to stimulate the processes of the seniors activation and counteracting social marginalization.
Catálogo de la exposición pictórica colectiva. Luces de Portugal en Sevilla
Authors: Graciani García Amparo
Published: September 2021

En el marco de la celebración en Sevilla del II Congreso Internacional sobre la Exposición Iberoamericana (CIEIA 2020), doce artistas, españolas y portuguesas, de luminosa pintura, comisariadas por Ana Feu, Carmen Sánchez Ruda y Amparo Graciani, reivindican el esplendor de la participación de Portugal en la Exposición Iberoamericana de Sevilla de 1929, reinterpretando La descarga de bacalao, una obra desaparecida realizada por el portuense Joaquim Lopes para la Sala de Comercio del pabellón portugués, y aportando cada una de ellas una obra individual con su particular homenaje a la presencia de Portugal en Sevilla.
Ensaio sobre racismo e ontologia: ser humano enquanto relações sociais não tematizadas
Authors: Barros Marcelo Vinicius Miranda
Published: September 2021

Motivadas pelo assassinato do afro-americano George Floyd por um policial branco no ano de 2020, manifestações contra o racismo se espalharam pelo mundo. Houve ainda o caso do brasileiro João Alberto Freitas, homem negro, de 40 anos, que foi espancado e morto por dois seguranças em um hipermercado. Todavia, fatos racistas, como os explanados que vieram à tona pela grande mídia, sempre existiram enquanto questões de lutas contra o genocídio racial em curso, pelo menos no Brasil, desde a colonização. Só que esses casos empíricos só são a ponta do iceberg. Há atitudes para além da ideia de raça, mas que criam desvantagens para um grupo racial. O nosso dia a dia está carregado de implicações imperícias e do mesmo modo ontológicas. Portanto, este ensaio não foge à regra desta conjuntura. O presente trabalho busca apreender a investigação desse fenômeno que será realizada, de um lado, a partir do conceito recentemente desenvolvido, a saber, as relações sociais não tematizadas; e, de outro, através de uma tentativa de aplicação de tal conceito em certos fatos sociais, como o racismo. O racismo continua agindo na contemporaneidade, no entanto, de forma cada vez mais complexa. Apreender suas dinâmicas depende não apenas de buscas empíricas, como também de direções teóricas sobre os dados ontológicos que o definem, como as relações sociais não tematizadas.
A fenomenologia como método científico para pesquisa em educação: análises de 2016 a 2019 em Roraima - UERR/IFRR
Authors: Costa Joice De Lima , De Oliveira Elialdo Rodrigues
Published: September 2021

Resumo: O presente artigo, iniciou-se a partir da disciplina Epistemologia das Ciências, quando foi abordado sobre a produção do conhecimento científico por meio do método de pesquisa Fenomenológica, o momento histórico no qual estava inserida, e as contribuições que propunha para seu uso, quanto método de pesquisa na Educação. Tendo em vista estas informações, neste artigo apresentamos uma reflexão sobre o rigor na pesquisa fenomenológica e o levantamento das pesquisas produzidas com essa metodologia no Programa de Pós-Graduação em Educação da Universidade Estadual de Roraima. O objetivo é propor questionamentos que fomentem diálogos e reflexões sobre o rigor do método fenomenológico na pesquisa educacional, demonstrando que os temas tratados se articulam como um desafio na ação educativa. Inicialmente, apresentamos os aspectos da abordagem fenomenológica, na pesquisa educacional, tendo como base metodológica a revisão bibliográfica e documental. Finalizando, apresentamos as pesquisas produzidas em Fenomenologia no PPGE – UERR/IRFF, demonstrando a predominância de pesquisas com a temática relacionada a prática docente e a convergência dos procedimentos metodológicos utilizados nos trabalhos estudados.Palavras chave: Fenomenologia. Método de Pesquisa. Educação. PPGE.
A Hermenêutica do Espaço: reflexões sobre a Realidade Geográfica de Eric Dardel
Authors: Neves Mariana Costa
Published: September 2021

Nenhuma outra reflexão revela-se tão fascinante quanto o conhecimento da realidade humana. E ressalte-se que as diferentes épocas e contextos históricos foram projetando, com insistência, sua imagem interpretativa do ser humano e, em consonância com ela, proclamaram os correspondentes códigos de conduta moral, principalmente os vinculados aos direcionamentos e postulados da Filosofia. E, de modo particular, a partir da Modernidade, o humanismo foi proposto como a condição de possibilidade do Conhecimento verdadeiro e como referência necessária para a vida e o fazer social. Nesse sentido, em 1952 foi publicada a obra O Homem e a Terra: Natureza da Realidade Geográfica, do geógrafo Eric Dardel, que foi traduzida para o português em 2011, a qual passou a versar sobre a realidade humana a partir da hermenêutica do espaço, refletindo sobre a realidade geográfica, numa perspectiva humanista. Esse trabalho surge, portanto, como resultado parcial de pesquisa de tese, desenvolvido entre os anos de 2016 e 2020, com o escopo de apresentar a Hermenêutica do Espaço. Nesse sentido, apresentar-se-á a realidade (geográfica) dardeliana a partir de unidades de significações naturais/espaciais, utilizando como premissa a construção de arquétipos fundantes de Bachelard, e as construções de mundo material/imaterial, real/irreal. E a Hermenêutica do Espaço dardeliano será subdividida em Unidades de Significação denominadas Espaço Geométrico (material e telúrico), Espaço Aquático, Espaço Aéreo, Espaço Construído e Espaço Mítico.
Hermenêuticas topológicas, Filosofia latinoamericana e pensamento decolonial: a tarefa de descolonizar nosso pensamento
Authors: Furtado de Melo Rebeca
Published: September 2021

O presente artigo parte de uma distinção entre duas compreensões de pensamento decolonial, uma mais abrangente e a outra que se refere especialmente ao trabalho desenvolvido pelo grupo Modernidade/colonialidade. A partir desta distinção, se articula algumas propostas deste grupo com a necessidade de desenvolvermos hermenêuticas topológicas a fim de sermos capazes, por um lado, de compreendermos nosso próprio lugar de enunciação e o acontecimento geohistórico que o instaura e atravessa e, por outro, de realizarmos a tarefa de descolonizarmos nosso pensamento e fazer filosófico.
Aflatoxicosis in dogs
Authors: Bates Nicola
Published: September 2021

Aflatoxins are toxic, naturally occurring bisfuranocoumarin compounds produced by certain strains of the moulds Aspergillus flavus, A. parasiticus and A. nomius. Aflatoxin metabolites cause hepatotoxicity by reacting with macromolecules (including DNA and proteins) to cause fatty liver or liver necrosis. Most cases involve dog food or, less commonly, ingestion of mouldy bread. Periodic outbreaks are reported in dogs, most recently at the end of 2020 to early 2021 in the US. Multiple dogs may be involved in incidents and the dogs usually present with gastrointestinal signs, lethargy, melaena and jaundice. Diagnosis is based on a history of possible ingestion and laboratory confirmation of aflatoxin(s) in suspect material. In the liver the typical histological changes are centrilobular necrosis of the liver and bile duct proliferation. Treatment of aflatoxicosis in dogs in supportive, with management of liver failure. Prognosis depends on the severity of liver damage, but mortality rates in dogs with aflatoxicosis are high.
Combining fascia lata autograft bridging repair with artificial ligament internal brace reinforcement
Authors: Bi Mingguang , Zhou Ke , Gan Kaifeng , Ding Wei , Zhang Ting , Ding Shaohua , Li Jin
Published: September 2021

Aims

The aim of this study is to provide a detailed description of cases combining bridging patch repair with artificial ligament “internal brace” reinforcement to treat irreparable massive rotator cuff tears, and report the preliminary results.

Methods

This is a retrospective review of patients with irreparable massive rotator cuff tears undergoing fascia lata autograft bridging repair with artificial ligament “internal brace” reinforcement technique between January 2017 and May 2018. Inclusion criteria were: patients treated arthroscopically for an incompletely reparable massive rotator cuff tear (dimension > 5 cm or two tendons fully torn), stage 0 to 4 supraspinatus fatty degeneration on MRI according to the Goutallier grading system, and an intact or reparable infraspinatus and/or subscapularis tendon of radiological classification Hamada 0 to 4. The surgical technique comprised two components: first, superior capsular reconstruction using an artificial ligament as an “internal brace” protective device for a fascia lata patch. The second was fascia lata autograft bridging repair for the torn supraspinatus. In all, 26 patients with a mean age 63.4 years (SD 6.2) were included.

Results

All patients underwent more than two years of follow-up (mean 33.5 months (24 to 45)). All clinical scores were also improved at two-year follow-up (mean visual analogue scale 0.7 (SD 0.5) vs 6.1 (SD 1.2); p < 0.001; mean American Shoulder and Elbow Surgeons score 93.5 (SD 5.3) vs 42.5 (SD 10.8); p < 0.001; mean University of California, Los Angeles score, 31.7 (SD 3.7) vs 12.0 (SD 3.1); p < 0.001; and mean Constant-Murley score 88.7 (SD 3.5) vs 43.3 (SD 10.9); p < 0.001), and 24 of 26 fascia lata grafts were fully healed on MRI (92%). One patient had haematoma formation at the harvesting side of the fascia lata at two days postoperatively.

Conclusion

The fascia lata autograft bridging repair combined with artificial ligament internal brace reinforcement technique achieved good functional outcomes, with a high rate of graft healing at two-year follow-up. Although the short-term results are promising, further studies with a greater number of patients would provide clearer results. Cite this article: Bone Joint J 2021;103-B(10):1619–1626.
Differences in mortality and complication rates following revision knee arthroplasty performed for urgent versus elective indications
Authors: Abram Simon G. F. , Sabah Shiraz A. , Alvand Abtin , Price Andrew J.
Published: September 2021

Aims

To compare rates of serious adverse events in patients undergoing revision knee arthroplasty with consideration of the indication for revision (urgent versus elective indications), and compare these with primary arthroplasty and re-revision arthroplasty.

Methods

Patients undergoing primary knee arthroplasty were identified in the national Hospital Episode Statistics (HES) between 1 April 1997 to 31 March 2017. Subsequent revision and re-revision arthroplasty procedures in the same patients and same knee were identified. The primary outcome was 90-day mortality and a logistic regression model was used to investigate factors associated with 90-day mortality and secondary adverse outcomes, including infection (undergoing surgery), pulmonary embolism, myocardial infarction, and stroke. Urgent indications for revision arthroplasty were defined as infection or fracture, and all other indications (e.g. loosening, instability, wear) were included in the elective indications cohort.

Results

A total of 939,021 primary knee arthroplasty procedures were included (939,021 patients), of which 40,854 underwent subsequent revision arthroplasty, and 9,100 underwent re-revision arthroplasty. Revision surgery for elective indications was associated with a 90-day rate of mortality of 0.44% (135/30,826; 95% confidence interval (CI) 0.37 to 0.52) which was comparable to primary knee arthroplasty (0.46%; 4,292/939,021; 95% CI 0.44 to 0.47). Revision arthroplasty for infection was associated with a much higher mortality of 2.04% (184/9037; 95% CI 1.75 to 2.35; odds ratio (OR) 3.54; 95% CI 2.81 to 4.46), as was revision for periprosthetic fracture at 5.25% (52/991; 95% CI 3.94 to 6.82; OR 6.23; 95% CI 4.39 to 8.85). Higher rates of pulmonary embolism, myocardial infarction, and stroke were also observed in the infection and fracture cohort.

Conclusion

Patients undergoing revision arthroplasty for urgent indications (infection or fracture) are at higher risk of mortality and serious adverse events in comparison to primary knee arthroplasty and revision arthroplasty for elective indications. These findings will be important for patient consent and shared decision-making and should inform service design for this patient cohort. Cite this article: Bone Joint J 2021;103-B(10):1578–1585.