bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacts of Atmospheric Pressure on the Annual Maximum of Monthly Sea-Levels in the Northeast Asian Marginal Seas
Authors: Han MyeongHee , Cho Yang-Ki , Kang Hyoun-Woo , Nam SungHyun , Byun Do-Seong , Jeong Kwang-Young , Lee Eunil
Published: June 2020

Monthly mean sea-levels have annual maxima in August in the northeast Asian marginal seas (NEAMS). Based on satellite altimetry data, the rising rate of the August NEAMS sea-level (ANS, 4.2 mm∙yr−1) is greater than those of the NEAMS (3.6 mm∙yr−1) and global (3.4 mm∙yr−1) annual mean sea-levels. Thus, the interannual variations of ANS are classified as relatively high (period H) and low (period L) years and have been analysed because of the high risk of sea-level fluctuation to the coastal regions in August. In period H, there are large atmospheric pressure gradients between the high pressure zone in the Kuroshio Extension (KE) and the low pressure zone in the west of Taiwan (WT). In period L, the atmospheric pressure gradients are small between the above-mentioned zones. Large atmospheric pressure gradients induce strong west-northwestward wind stresses and more Ekman transport from the northwest Pacific Ocean into the NEAMS. The correlation coefficient between August NEAMS sea-level index (ANSI), which is the difference of atmospheric pressure anomalies between the KE and the WT, and the August NEAMS sea-level anomaly (ANSA) is 0.73. Although there is a significant correlation (coefficient: 0.64) between ANSA and the East Asian summer monsoon index (EASMI), ANSI might be more useful in estimating the variability of ANSA.
Denoising Effect of Jason-1 Altimeter Waveforms with Singular Spectrum Analysis: A Case Study of Modelling Mean Sea Surface Height over South China Sea
Authors: Yuan Jiajia , Guo Jinyun , Niu Yupeng , Zhu Chengcheng , Li Zhen , Liu Xin
Published: June 2020

Altimeter waveforms are usually contaminated due to nonmarine surfaces or inhomogeneous sea state conditions. The present work aimed to present how the singular spectrum analysis (SSA) can be used to reduce the noise level in Jason-1 altimeter waveforms to obtain SSA-denoised waveforms, improving the accuracy of a mean sea surface height (MSSH) model. Comparing the retracked sea surface heights (SSHs) by a 50% threshold retracker for the SSA-denoised waveforms with those for the raw waveforms, the results indicated that SSA allowed a noise reduction on Jason-1 waveforms, improving the accuracy of retracked SSHs. The MSSH model (called Model 1) over the South China Sea with a grid of 2′ × 2′ was established from the retracked SSHs of Jason-1 by the 50% threshold retracker for the SSA-denoised waveforms. Comparing Model 1 and Model 2 (established from the retracked SSHs by the 50% threshold retracker for the raw waveforms) with the CLS15 and DTU18 models in the South China Sea, it was found that the accuracy of Model 1 was higher than that of Model 2, which indicates that using SSA to reduce noise level in Jason-1 waveforms can effectively improve the accuracy of the MSSH model.
Complete Asymptotics for Solution of Singularly Perturbed Dynamical Systems with Single Well Potential
Authors: Borisov Denis I. , Sultanov Oskar A.
Published: June 2020

We consider a singularly perturbed boundary value problem ( − ε 2 ∆ + ∇ V · ∇ ) u ε = 0 in Ω , u ε = f on ∂ Ω , f ∈ C ∞ ( ∂ Ω ) . The function V is supposed to be sufficiently smooth and to have the only minimum in the domain Ω . This minimum can degenerate. The potential V has no other stationary points in Ω and its normal derivative at the boundary is non-zero. Such a problem arises in studying Brownian motion governed by overdamped Langevin dynamics in the presence of a single attracting point. It describes the distribution of the points at the boundary ∂ Ω , at which the trajectories of the Brownian particle hit the boundary for the first time. Our main result is a complete asymptotic expansion for u ε as ε → + 0 . This asymptotic is a sum of a term K ε Ψ ε and a boundary layer, where Ψ ε is the eigenfunction associated with the lowest eigenvalue of the considered problem and K ε is some constant. We provide complete asymptotic expansions for both K ε and Ψ ε ; the boundary layer is also an infinite asymptotic series power in ε . The error term in the asymptotics for u ε is estimated in various norms.
Financial Technology: Review of Trends, Approaches and Management
Authors: Abad-Segura Emilio , González-Zamar Mariana-Daniela , López-Meneses Eloy , Vázquez-Cano Esteban
Published: June 2020

Technological innovation and digitization have posed a challenge to the financial sector globally. Fintech is the term used to designate the application of new technologies to financial services. The aim of the study is to analyse this research subject worldwide during the period 1975–2019. To this end, bibliometric techniques were applied to 2012 articles, obtaining findings of the productivity of scientific research, of the main thematic axes and their evolution. Scientific activity increased, mainly in the past decade, with 45% of publications. The main thematic areas were Business, Management and Accounting, Engineering, Social Sciences and Computer Science. Seven research lines were identified, aimed at analysing the aspects financial, economic, technology transfer, investment, innovation, partnerships and institutions and commercial. Future research lines should develop analyses on banking, financial services trade, territorial development, legal, management, research methodologies and the sustainability of financial technologies. It was verified that there is a growing and dynamic interest in scientific activity on financial technologies at an international level. The findings obtained are a complement to the knowledge of financial technologies and allow the relationship between science and technology to be established, and to inform the decision-making process.
Did Institutional Investors’ Behavior Affect U.S.-China Equity Market Sentiment? Evidence from the U.S.-China Trade Turbulence
Authors: Lin Shu-Ling , Lu Jun
Published: June 2020

In the current situation of U.S.-China trade turbulence, this study focuses on quarterly panel data from May 2016 to September 2019 in order to verify the effectiveness of feedback trading strategy and smart money theory in stabilizing U.S.-China securities markets and to understand the role of institutional investors’ behavior, to come up with suggestions for improving and perfecting the market mechanism in stabilizing the U.S.-China securities markets. In this study, we adopt the generalized method of moments (GMM) to perform dynamic panel data analysis and discuss the changes in professional institutional investors’ behavior and equity market sentiment in the U.S. and China during the trade turbulence, and then analyze whether that behavior will suppress local stock market sentiment. Through empirical research, we found that institutional investors on both sides of the trade turbulence have a different impact on the stability of the local securities market. The behavior of institutional investors in the United States has played a role in stabilizing equity market sentiment in accordance with feedback trading strategy and smart money theory. However, the behavior of institutional investors in China is the opposite.
Functionalization of 3D Chitinous Skeletal Scaffolds of Sponge Origin Using Silver Nanoparticles and Their Antibacterial Properties
Authors: Machałowski Tomasz , Czajka Maria , Petrenko Iaroslav , Meissner Heike , Schimpf Christian , Rafaja David , Ziętek Jerzy , Dzięgiel Beata , Adaszek Łukasz , Voronkina Alona , Kovalchuk Valentin , Jaroszewicz Jakub , Fursov Andriy , Rahimi-Nasrabadi Mehdi , Stawski Dawid , Bechmann Nicole , Jesionowski Teofil , Ehrlich Hermann
Published: June 2020

Chitin, as one of nature’s most abundant structural polysaccharides, possesses worldwide, high industrial potential and a functionality that is topically pertinent. Nowadays, the metallization of naturally predesigned, 3D chitinous scaffolds originating from marine sponges is drawing focused attention. These invertebrates represent a unique, renewable source of specialized chitin due to their ability to grow under marine farming conditions. In this study, the development of composite material in the form of 3D chitin-based skeletal scaffolds covered with silver nanoparticles (AgNPs) and Ag-bromide is described for the first time. Additionally, the antibacterial properties of the obtained materials and their possible applications as a water filtration system are also investigated.
Reduced Stroke Risk among Patients with Atrial Fibrillation Receiving Chinese Herbal Medicines Treatment: Analysis of Domestic Data in Taiwan
Authors: Zheng Li-Cheng , Livneh Hanoch , Chen Wei-Jen , Lin Miao-Chiu , Lu Ming-Chi , Yeh Chia-Chou , Tsai Tzung-Yi
Published: June 2020

Background and objectives: Patients with atrial fibrillation (AF) reportedly have a much higher risk of death due to stroke. Faced with this heavy burden, it remains unclear if the Chinese herbal medicines (CHMs), the most common form complementary and alternative medicine, can lower the risk of stroke for them. This study aimed to evaluate the association of CHMs use with stroke risk among them. Materials and Methods: From a nationwide database, 11,456 AF patients aged ≧ 20 years between 1998 and 2007 were identified. Afterwards, we enrolled 2670 CHMs users and randomly selected 2670 non-CHMs users using the propensity score method. The occurrence of stroke was recorded until the end of 2012. Results: Within the follow-up period, 671 CHMs users and 900 non-CHMs users developed stroke, with incidence rates of 33.02 and 45.46 per 1000 person-years, respectively. CHMs use was associated with a 30% lower stroke risk, especially for those receiving CHMs for over two years. Conclusions: The findings of the present study suggest that adding CHMs to conventional therapy could decrease subsequent stroke risk for AF patients. It is also suggested that prospective randomized trials are needed to further clarify if the detected association revealed in this study supports a causal link, and to identify the specific CHMs that may be beneficial to AF patients.
Ecometabolomics for a Better Understanding of Plant Responses and Acclimation to Abiotic Factors Linked to Global Change
Authors: Sardans Jordi , Gargallo-Garriga Albert , Urban Otmar , Klem Karel , Walker Tom W.N. , Holub Petr , Janssens Ivan A. , Peñuelas Josep
Published: June 2020

The number of ecometabolomic studies, which use metabolomic analyses to disentangle organisms’ metabolic responses and acclimation to a changing environment, has grown exponentially in recent years. Here, we review the results and conclusions of ecometabolomic studies on the impacts of four main drivers of global change (increasing frequencies of drought episodes, heat stress, increasing atmospheric carbon dioxide (CO2) concentrations and increasing nitrogen (N) loads) on plant metabolism. Ecometabolomic studies of drought effects confirmed findings of previous target studies, in which most changes in metabolism are characterized by increased concentrations of soluble sugars and carbohydrate derivatives and frequently also by elevated concentrations of free amino acids. Secondary metabolites, especially flavonoids and terpenes, also commonly exhibited increased concentrations when drought intensified. Under heat and increasing N loads, soluble amino acids derived from glutamate and glutamine were the most responsive metabolites. Foliar metabolic responses to elevated atmospheric CO2 concentrations were dominated by greater production of monosaccharides and associated synthesis of secondary metabolites, such as terpenes, rather than secondary metabolites synthesized along longer sugar pathways involving N-rich precursor molecules, such as those formed from cyclic amino acids and along the shikimate pathway. We suggest that breeding for crop genotypes tolerant to drought and heat stress should be based on their capacity to increase the concentrations of C-rich compounds more than the concentrations of smaller N-rich molecules, such as amino acids. This could facilitate rapid and efficient stress response by reducing protein catabolism without compromising enzymatic capacity or increasing the requirement for re-transcription and de novo biosynthesis of proteins.
Skin Microbiome Analysis for Forensic Human Identification: What Do We Know So Far?
Authors: Tozzo Pamela , D’Angiolella Gabriella , Brun Paola , Castagliuolo Ignazio , Gino Sarah , Caenazzo Luciana
Published: June 2020

Microbiome research is a highly transdisciplinary field with a wide range of applications and methods for studying it, involving different computational approaches and models. The fact that different people host radically different microbiota highlights forensic perspectives in understanding what leads to this variation and what regulates it, in order to effectively use microbes as forensic evidence. This narrative review provides an overview of some of the main scientific works so far produced, focusing on the potentiality of using skin microbiome profiling for human identification in forensics. This review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The examined literature clearly ascertains that skin microbial communities, although personalized, vary systematically across body sites and time, with intrapersonal differences over time smaller than interpersonal ones, showing such a high degree of spatial and temporal variability that the degree and nature of this variability can constitute in itself an important parameter useful in distinguishing individuals from one another. Even making the effort to organically synthesize all results achieved until now, it is quite evident that these results are still the pieces of a puzzle, which is not yet complete.
Changes in the Intestinal Microbiota of Patients with Inflammatory Bowel Disease with Clinical Remission during an 8-Week Infliximab Infusion Cycle
Authors: Seong Gyeol , Kim Namil , Joung Je-Gun , Kim Eun Ran , Chang Dong Kyung , Chun Jongsik , Hong Sung Noh , Kim Young-Ho
Published: June 2020

This study investigated changes in the intestinal microbiota during 8-week infliximab maintenance therapy in inflammatory bowel disease (IBD) patients in clinical remission. Microbial compositional differences were analyzed according to the trough level of infliximab (TLI) and mucosal healing (MH) status. 16S rRNA gene-based microbiome profiling was performed on 10 and 74 fecal samples from 10 healthy volunteers and 40 adult IBD patients, respectively. Fecal sampling occurred at 1–2 weeks (1W) and 7–8 weeks (7W) after infliximab infusion. TLI was measured by ELISA at 8 weeks, immediately before the subsequent infusion; MH was evaluated by endoscopy within 3 months. There were no significant changes in microbial composition, species richness, or diversity indices between 1W and 7W. However, 7W samples from the patients with TLI ≥ 5 μg/mL showed an increased species richness compared with patients with TLI < 5 μg/mL, and patients with MH showed increased diversity compared with non-MH patients. Beta-diversity analysis showed clustering between samples in the MH and non-MH groups. LEfSe analysis identified differential composition of Faecalibacterium prausnitzii group according to TLI and MH. In conclusion, these results suggest the potential of fecal microbiota as a response indicator.
Recovery of Vaginal Microbiota after Standard Treatment for Bacterial Vaginosis Infection: An Observational Study
Authors: Lehtoranta Liisa , Hibberd Ashley A. , Reimari Jenni , Junnila Jouni , Yeung Nicolas , Maukonen Johanna , Crawford Gordon , Ouwehand Arthur C.
Published: June 2020

Vaginal microbiota dysbiosis and bacterial vaginosis (BV) affect negatively women’s health. Understanding vaginal microbiota fluctuations in BV during and after antibiotic treatment would facilitate accurate decision-making on the treatment regimen, avoid unnecessary antibiotic use, and potentially mitigate recurrence. We investigated vaginal microbiota composition of 30 women with BV before and after 5-day metronidazole treatment and compared the results with 30 healthy women. Vaginal microbiota was assessed by Nugent score and analyzed by 16S rRNA gene sequencing in swabs on baseline Day 1, and on Day 8 and 15, after completion of antibiotic treatment by women with BV. Prior to antibiotic treatment (Day 1), BV-positive women were dominated by Lactobacillus iners (25.8%), Prevotella timonensis/bivia (18.0%), and Gardnerella vaginalis (14.6%), whereas healthy women were dominated by L. iners (37.5%) and Lactobacillus crispatus/acidophilus (19.2%). On Day 8, L. iners abundance increased in BV-treated women being significantly higher compared with healthy women (67.8% vs. 37.5%, p = 0.049). On Day 15, the relative abundance of all microbial taxa was similar between the groups. Vaginal microbiota of women with BV shifted to resemble that of healthy controls after metronidazole. Sequencing analysis provides more in-depth understanding of changes in vaginal microbiota. The role of L. iners in vaginal health and dysbiosis requires further investigations.
The Lactobacillus brevis 47 f Strain Protects the Murine Intestine from Enteropathy Induced by 5-Fluorouracil
Authors: Marsova Maria , Odorskaya Maya , Novichkova Maria , Polyakova Valentina , Abilev Serikbay , Kalinina Elena , Shtil Alexander , Poluektova Elena , Danilenko Valery
Published: June 2020

We report that the results of our study indicate that Lactobacillus brevis 47 f strain isolated from the faeces of a healthy individual prevents the manifestations of experimental mucositis induced by treatment of Balb/c mice with the anticancer drug 5-fluorouracil (5 FU; 100 mg/kg i.p. × 3 days). The presence of damage to the intestine and the colon was determined by a morphometric analysis of specimens including the height of villi, the amount of goblet cells and infiltrating mononuclear cells, and the expression of the proliferative Ki-67 antigen. Changes in the lipid peroxidation in the blood and the intestine were determined by severalfold increase of the concentration of malonic dialdehyde. Oral administration of L. brevis 47 f strain prior to 5 FU decreased the drug-induced morphological and biochemical changes to their respective physiological levels; the ability of intestinal epitheliocytes to express Ki-67 was partially restored. These effects of L. brevis 47 f strain were more pronounced or similar to those of the reference compound Rebamipid, a quinoline derivative known to protect the gut from drug-induced toxicity. Thus, the new lactobacilli strain attenuates the severity of 5 FU-induced enteropathy.
On the Ferroelectric to Paraelectric Structural Transition of BaTiO3 Micro-/Nanoparticles and Their Epoxy Nanocomposites
Authors: Manika Georgia C. , Andrikopoulos Konstantinos S. , Psarras Georgios C.
Published: June 2020

BaTiO3 is one of the most widely used ceramic components in capacitor formulation due to its exceptional ferroelectric properties. The structural transition from the ferroelectric tetragonal to the paraelectric cubic phase has been studied in both nano- and micro-BaTiO3 particles. Several experimental techniques were employed for characterization purposes (X-ray diffraction-XRD, laser Raman spectroscopy-LRS, differential scanning calorimetry-DSC and broadband dielectric spectroscopy-BDS). All gave evidence for the structural transition from the polar tetragonal to the non-polar cubic phase in both nano- and micro-BaTiO3 particles. Variation of Full Width at Half Maximum (FWHM) with temperature in XRD peaks was employed for the determination of the critical Curie temperature (Tc). In micro-BaTiO3 particles (Tc) lies close to 120 °C, while in nanoparticles the transition is complicated due to the influence of particles’ size. Below (Tc) both phases co-exist in nanoparticles. (Tc) was also determined via the temperature dependence of FWHM and found to be 115 °C. DSC, LRS and BDS provided direct results, indicating the transition in both nano- and micro-BaTiO3 particles. Finally, the 15 parts per hundred resin per weight (phr) BaTiO3/epoxy nanocomposite revealed also the transition through the peak formation at approximately 130 °C in the variation of FWHM with temperature. The present work introduces, for the first time, a qualitative tool for the determination and study of the ferroelectric to paraelectric structural transition in both nano- and micro-ferroelectric particles and in their nanocomposites. Moreover, its novelty lies on the effect of crystals’ size upon the ferroelectric to the paraelectric phase transition and its influence on physical properties of BaTiO3.
Zinc Phthalocyanine Photochemistry by Raman Imaging, Fluorescence Spectroscopy and Femtosecond Spectroscopy in Normal and Cancerous Human Colon Tissues and Single Cells
Authors: Brozek-Pluska Beata , Jarota Arkadiusz , Kania Rafal , Abramczyk Halina
Published: June 2020

Photodynamic therapy is a clinically approved alternative method for cancer treatment in which a combination of nontoxic drugs known as photosensitizers and oxygen is used. Despite intensive investigations and encouraging results, zinc phthalocyanines (ZnPcs) have not yet been approved as photosensitizers for clinical use. Label-free Raman imaging of nonfixed and unstained normal and cancerous colon human tissues and normal human CCD18-Co and cancerous CaCo-2 cell lines, without and after adding ZnPcS4 photosensitizer, was analyzed. The biochemical composition of normal and cancerous colon tissues and colon cells without and after adding ZnPcS4 at the subcellular level was determined. Analyzing the fluorescence/Raman signals of ZnPcS4, we found that in normal human colon tissue samples, in contrast to cancerous ones, there is a lower affinity to ZnPcS4 phthalocyanine. Moreover, a higher concentration in cancerous tissue was concomitant with a blue shift of the maximum peak position specific for the photosensitizer from 691–695 nm to 689 nm. Simultaneously for both types of samples, the signal was observed in the monomer region, confirming the excellent properties of ZnPcS4 for photo therapy (PDT). For colon cell experiments with a lower concentration of ZnPcS4 photosensitizer, c = 1 × 10−6 M, the phthalocyanine was localized in mitochondria/lipid structures; for a higher concentration, c = 9 × 10−6 M, localization inside the nucleus was predominant. Based on time-resolved experiments, we found that ZnPcS4 in the presence of biological interfaces features longer excited-state lifetime photosensitizers compared to the aqueous solution and bare ZnPcS4 film on CaF2 substrate, which is beneficial for application in PDT.
In Vitro Metabolic Transformation of Pharmaceuticals by Hepatic S9 Fractions from Common Carp (Cyprinus carpio)
Authors: Burkina Viktoriia , Sakalli Sidika , Giang Pham Thai , Grabicová Kateřina , Staňová Andrea Vojs , Zamaratskaia Galia , Zlabek Vladimir
Published: June 2020

Water from wastewater treatment plants contains concentrations of pharmaceutically active compounds as high as micrograms per liter, which can adversely affect fish health and behavior, and contaminate the food chain. Here, we tested the ability of the common carp hepatic S9 fraction to produce the main metabolites from citalopram, metoprolol, sertraline, and venlafaxine. Metabolism in fish S9 fractions was compared to that in sheep. The metabolism of citalopram was further studied in fish. Our results suggest a large difference in the rate of metabolites formation between fish and sheep. Fish hepatic S9 fractions do not show an ability to form metabolites from venlafaxine, which was also the case for sheep. Citalopram, metoprolol, and sertraline were metabolized by both fish and sheep S9. Citalopram showed concentration-dependent N-desmethylcitalopram formation with Vmax = 1781 pmol/min/mg and Km = 29.7 μM. The presence of ellipticine, a specific CYP1A inhibitor, in the incubations reduced the formation of N-desmethylcitalopram by 30–100% depending on the applied concentration. These findings suggest that CYP1A is the major enzyme contributing to the formation of N-desmethylcitalopram. In summary, the results from the present in vitro study suggest that common carp can form the major metabolites of citalopram, metoprolol, and sertraline.
Developing an Improved UHPLC Method for Efficient Determination of European Pharmacopeia Process-Related Impurities in Ropinirole Hydrochloride Using Analytical Quality by Design Principles
Authors: Tome Tim , Obreza Aleš , Časar Zdenko
Published: June 2020

This article presents the development of a reversed-phase ultra-high-performance liquid chromatographic method for determining process-related impurities in ropinirole hydrochloride drug substance applying the analytical quality by design approach. The current pharmacopeial method suffers from selectivity issues due to two coelutions of two pairs of impurities. The development of a new method began with preliminary experiments, based on which the Acquity UPLC BEH C8 was selected as the most appropriate column. The effects of six different critical method parameters (CMPs) were then investigated using a fractional factorial screening design. Column temperature, the ratio of methanol in mobile phase B, and gradient slope turned out to be highly significant CMPs in achieving critical resolutions, and they were further evaluated using a central composite face-centered response-surface design. Mathematical models were created by applying a multiple linear regression method. Based on the elution order of an unknown degradation impurity and impurity C, two design spaces were established, and for each design space an optimal combination of CMPs was determined. The method developed was validated for precision, accuracy, linearity, and sensitivity, and it was proven suitable for determining nine process-related impurities of ropinirole.
Changes in Dietary Behaviours during the COVID-19 Outbreak Confinement in the Spanish COVIDiet Study
Authors: Rodríguez-Pérez Celia , Molina-Montes Esther , Verardo Vito , Artacho Reyes , García-Villanova Belén , Guerra-Hernández Eduardo Jesús , Ruíz-López María Dolores
Published: June 2020

The aim of this study was to evaluate whether dietary behaviours of the Spanish adult population were changed during the COVID-19 outbreak confinement. For that purpose, an online questionnaire, based on 44 items including socio-demographic data, Mediterranean diet (MedDiet) Adherence Screener (MEDAS) as a reference of a healthy diet, processed foods intake, changes in their usual food choices and weight gain was distributed using social media and snowball sampling. A total of 7514 participants (37% aged below 35 years, 70.6% female, 77.9% university-level education or higher) from all the Spanish territory completed the questionnaire. Results outlined healthier dietary behaviours during the confinement when compared to previous habits. Overall, the MEDAS score (ranging from 0 to 14, whereby higher a scoring reflects greater adherence to the MedDiet) increased significantly from 6.53 ± 2 to 7.34 ± 1.93 during the confinement. Multivariate logistic regression models, adjusted for age, gender, region and other variables, showed a statistically significant higher likelihood of changing the adherence to the MedDiet (towards an increase in adherence) in those persons who decreased the intake of fried foods, snacks, fast foods, red meat, pastries or sweet beverages, but increased MedDiet-related foods such as olive oil, vegetables, fruits or legumes during the confinement. COVID-19 confinement in Spain has led to the adoption of healthier dietary habits/behaviours in the studied population, as reflected by a higher adherence to the MedDiet. This improvement, if sustained in the long-term, could have a positive impact on the prevention of chronic diseases and COVID-19-related complications.
Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days
Authors: Derbyshire Emma , Obeid Rima
Published: June 2020

The foundations of neurodevelopment across an individual’s lifespan are established in the first 1000 days of life (2 years). During this period an adequate supply of nutrients are essential for proper neurodevelopment and lifelong brain function. Of these, evidence for choline has been building but has not been widely collated using systematic approaches. Therefore, a systematic review was performed to identify the animal and human studies looking at inter-relationships between choline, neurological development, and brain function during the first 1000 days of life. The database PubMed was used, and reference lists were searched. In total, 813 publications were subject to the title/abstract review, and 38 animal and 16 human studies were included after evaluation. Findings suggest that supplementing the maternal or child’s diet with choline over the first 1000 days of life could subsequently: (1) support normal brain development (animal and human evidence), (2) protect against neural and metabolic insults, particularly when the fetus is exposed to alcohol (animal and human evidence), and (3) improve neural and cognitive functioning (animal evidence). Overall, most offspring would benefit from increased choline supply during the first 1000 days of life, particularly in relation to helping facilitate normal brain development. Health policies and guidelines should consider re-evaluation to help communicate and impart potential choline benefits through diet and/or supplementation approaches across this critical life stage.
Calcium Improves Germination and Growth of Sorghum bicolor Seedlings under Salt Stress
Authors: Mulaudzi Takalani , Hendricks Kaylin , Mabiya Thembeka , Muthevhuli Mpho , Ajayi Rachel Fanelwa , Mayedwa Noluthando , Gehring Christoph , Iwuoha Emmanuel
Published: June 2020

Salinity is a major constraint limiting plant growth and productivity worldwide. Thus, understanding the mechanism underlying plant stress response is of importance to developing new approaches that will increase salt tolerance in crops. This study reports the effects of salt stress on Sorghum bicolor during germination and the role of calcium (Ca2+) to ameliorate some of the effects of salt. To this end, sorghum seeds were germinated in the presence and absence of different NaCl (200 and 300 mM) and Ca2+ (5, 15, or 35 mM) concentrations. Salt stress delayed germination, reduced growth, increased proline, and hydrogen peroxide (H2O2) contents. Salt also induced the expression of key antioxidant (ascorbate peroxidase and catalase) and the Salt Overlay Sensitive1 genes, whereas in the presence of Ca2+ their expression was reduced except for the vacuolar Na+/H+ exchanger antiporter2 gene, which increased by 65-fold compared to the control. Ca2+ reversed the salt-induced delayed germination and promoted seedling growth, which was concomitant with reduced H2O2 and Na+/K+ ratio, indicating a protective effect. Ca2+ also effectively protected the sorghum epidermis and xylem layers from severe damage caused by salt stress. Taken together, our findings suggest that sorghum on its own responds to high salt stress through modulation of osmoprotectants and regulation of stress-responsive genes. Finally, 5 mM exogenously applied Ca2+ was most effective in enhancing salt stress tolerance by counteracting oxidative stress and improving Na+/K+ ratio, which in turn improved germination efficiency and root growth in seedlings stressed by high NaCl.
Encapsulation of Bioactive Compounds from Aloe Vera Agrowastes in Electrospun Poly (Ethylene Oxide) Nanofibers
Authors: Solaberrieta Ignacio , Jiménez Alfonso , Cacciotti Ilaria , Garrigós Maria Carmen
Published: June 2020

Aloe Vera is an ancient medicinal plant especially known for its beneficial properties for human health, due to its bioactive compounds. In this study, nanofibers with antioxidant activity were successfully obtained by electrospinning technique with the addition of a natural Aloe Vera skin extract (AVE) (at 0, 5, 10 and 20 wt% loadings) in poly(ethylene oxide) (PEO) solutions. The successful incorporation of AVE into PEO was evidenced by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (ATR-FTIR), thermogravimetric analysis (TGA) and antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging (ABTS) and ferric reducing power (FRAP) assays. The incorporation of AVE introduced some changes in the PEO/AVE nanofibers morphology showing bimodal diameter distributions for AVE contents in the range 10-20 wt%. Some decrease in thermal stability with AVE addition, in terms of decomposition onset temperature, was also observed and it was more evident at high loading AVE contents (10 and 20 wt%). High encapsulation efficiencies of 92%, 76% and 105% according to DPPH, FRAP and ABTS assays, respectively, were obtained at 5 wt% AVE content, retaining AVE its antioxidant capacity in the PEO/AVE electrospun nanofibers. The results suggested that the obtained nanofibers could be promising materials for their application in active food packaging to decrease oxidation of packaged food during storage.
Monitoring of Biochemical Parameters and GHG Emissions in Bioaugmented Manure Composting
Authors: Yaman Cevat
Published: June 2020

Composting is a sustainable alternative for the management of manure. In this study, the effects of bioaugmentation on cattle manure composting was investigated. In this study, two windrow piles were placed at 1.7 m in height, 2.1 m in bottom width, 0.6 m in top width, and 54 m in length. Microbial inoculum was added to pile 1, whereas the second pile was used as the control. After 17 days, the C:N ratio was reduced from 25.6 to 13.6 and the total nitrogen was increased from 1.89% to 3.36% in pile 1. The dominant bacteria identified in the compost samples belonged to the genera Clostridium, Bacillus, and Flavobacterium. Quantitative polymerase chain reaction indicated that the most commonly known pathogenic bacteria, Escherichia coli, Shigella, and Salmonella, were not detected in the finished material, indicating that the pathogenic microorganisms were inactivated by the composting process. Agronomic testing for cured compost indicated a C:N ratio of less than 15 and NH+4-N:NO3−-N ratio of less than 1. The whole process of windrow composting resulted in net greenhouse gas (GHG) emissions of 157.94 tCO2-e and a global warming factor (GWF) of 1.04 tCO2-e·t−1 manure composted. This study showed that although bioaugmentation is a feasible treatment method for manure, GHG emissions need to be monitored.
Recultivation of Post-Mining Disturbed Land: Review of Content and Comparative Law and Feasibility Study
Authors: Ignatyeva Margarita , Yurak Vera , Pustokhina Natalia
Published: June 2020

The article considers the concept of the circular economy as an important tool for achieving sustainable development, which relates to the preservation of renewable resources’ mass through the renewal of withdrawn resources and the restoration of disturbed ones. It is directly linked to remedial land treatment in post-mining disturbed land. However, after numerous studies, the conceptual apparatus of recultivation remains unspecified. Moreover, there is a gap regarding the trends of evolutionary changes in studies of legislation and feasibility on the subject of recultivation. Employing comparative law as a tool, the aim of the study is to develop a consistent approach based on circular economy by establishing the stages of legal support for recultivation and identifying the content of all these stages regarding economic efficiency. Currently, the environmental priorities of the economy are triggering the usage of the ecosystem approach for assessing the ecological result of recultivation. Therefore, the core of the paper is the development of a consistent circular economy approach by (1) clarifying the concept of recultivation, (2) identifying the stages of the development of a legal framework for recultivation and (3) revealing evolutionary changes in feasibility studies on recultivation. The authors prove that recultivation should be considered from the perspective of geoaesthetics, which implies a harmonious incorporation of the recultivated landscape into the environment.
Characterization and Sensing of Inert Gases with a High-Resolution SPR Sensor
Authors: Liu Zhenchao , He Jinlong , He Sailing
Published: June 2020

It is generally difficult to characterize inert gases through chemical reactions due to their inert chemical properties. The phase interference-sensing system based on high-resolution surface plasmon resonance (SPR) has an excellent refractive index detection limit. Based on this, this paper presents a simple and workable method for the characterization and detection of inert gases. The phase of light for the present SPR sensor is more sensitive to the change in the external dielectric environment than an amplitude SPR sensor. The limit of detection (LOD) is usually in the order of 10−6 to 10−7 RIU, which is superior to LSPR (Localized Surface Plasmon Resonance) sensors and traditional SPR sensors. The sensor parameters are simulated and optimized. Our simulation shows that a 36 nm-thick gold film is more suitable for the SPR sensing of inert gases. By periodically switching between the two inert gases, helium and argon, the resolution of the system is tested. The SPR sensing system can achieve distinguishable difference signals, enabling a clear distinction and characterization of helium and argon. The doping of argon in helium has a detection limit of 1098 ppm.
Fish Oil and Fish Meal Production from Urban Fisheries Biomass in Japan
Authors: Ido Atsushi , Kaneta Mika
Published: June 2020

Finding an alternative feed source for the replacement of fish oil (FO) and fish meal (FM) produced from whole fish has been an important issue for realizing sustainable aquaculture. In this study, fishery by-products generated in the distribution phase, known as urban fisheries biomass (UFB), were focused on. The quality parameter and nutrient components of FO and FM from UFB were analyzed. Although crude FO produced from UFB showed relatively poor quality properties, the refinement process made an improvement of the quality to make it comparable to commercially available FO. There is no big variation in several samples in fatty acid profiles of FO and amino acid profiles of FM, and they seem to be able to replace FO and FM from whole fish in the diet for cultured fish. The utilization of UFB should be promoted in economic and ecologic aspects; however, in use of the FM, there remains a risk of intra-species recycling that might lead to transmissible spongiform encephalopathy. Furthermore, we must take into consideration the possibility of contamination of fishery products from at-risk species and illegal, unreported, and unregulated (IUU) fisheries due to the lack of regulations in Japan.
Investigation of the Pillars of Sustainability Risk Management as an Extension of Enterprise Risk Management on Palestinian Insurance Firms’ Profitability
Authors: Shaheen Rami , Ağa Mehmet , Rjoub Husam , Abualrub Ahmad
Published: June 2020

This research paper examined the simultaneous relationship between sustainability risk management (SRM) as an extension of Enterprise Risk Management (ERM) and Palestinian insurance firms’ profitability, for the period spanning 2007Q1 to 2018Q4, by applying the panel dynamic (Generalized Method of Moments) GMM model. The literature was expanded by providing a comprehensive understanding of determining the pillars of ERM with the use of the factor analysis principle component method. The findings revealed that the firm’s profitability positively corresponded to ERM1 implementation, which represents “management efficiency”. In contrast, it shows negative correspondence to ERM2 implementation, which represents “control and ownership”. Furthermore, there were slightly negative signs from managing the use of leverage and they were conservative in terms of loss reserves. The challenges of firms’ profitability have negatively corresponded to emerging sustainability risks, such as political stability, that cause premiums written to show weak signs of excessive choice of risk or prices that are not met carefully. Interestingly, there is a positive relationship in the interaction between ERM2 implementation during the crisis period on insurance firms’ profitability. There is a robust causal relationship from ERM to the profitability (either positive or negative). The reverse causality is also significant but to a lesser extent. Thus, the study recommends alignment more coherent with the implication of ERM as holistic risk according to the market characteristic towards the environmental perils leads to sustainable development and its segments to maintain the longer term of survival in the firms’ performance.
Cycling Master Plans in Italy: The I-BIM Feasibility Tool for Cost and Safety Assessments
Authors: Campisi Tiziana , Acampa Giovanna , Marino Giorgia , Tesoriere Giovanni
Published: June 2020

Interest towards urban micromobility has been growing lately, and it will now increase further due to the measures used against COVID-19. It is recommended to avoid close contact to prevent contagion. Municipalities have been called to implement wider cycling networks so that people may go to their work place by cycling rather than by using public transport. This paper focused on cycling path design using an infrastructure-building information model (I-BIM). The issue covered was how to connect cost and safety requirements in the first steps of the project. We set a methodology that gives, after identifying the intervention area and defining the available economic resources, the key elements needed to design possible cycle path solutions. It guides the designer step-by-step, starting from basic assumptions related to a cycle path’s location (urban/non-urban), budget (by range), and safety (according to Bicycle Compatibility Index BCI and Bicycle Level of Service (BLOS) index), up to the definition of preferred options in terms of materials to be selected. As a case study, we implemented this methodology in the old city center of Catania in Sicily (Italy), designing a cycle path that connects the city center with the existing cycle path on the coast, while aligning with safety requirements within budget constraints.
Community-Based Tourism as a Factor in Socio-Ecological Resilience. Economic Diversification and Community Participation in Floreana (Galapagos)
Authors: Ruiz-Ballesteros Esteban , del Campo Tejedor Alberto
Published: June 2020

In order to understand the effect of community-based tourism (CBT) on sustainability, bespoke instruments are required. This paper advocates the application of resilience thinking as a theoretical-methodological resource suited to this purpose. The methodological perspective proposed here focuses on two core elements in the functioning of any socio-ecosystem in which CBT is developed: (1) diversification of productive activities; and (2) collective participation in tourism. To reflect on this proposal empirically, an ethnographic case study was conducted on the island of Floreana (Galapagos). The analysis shows that resilience thinking is an appropriate strategy to study the effect and significance of CBT with regard to the general resilience of the socio-ecosystem and, therefore, the sustainability of its desired configuration. The analytical perspective proposed here allows us to understand: (1) how CBT functions in a specific case; (2) its contribution to the resilience of the socio-ecosystem; and (3) the consistency of that resilience by virtue of the functioning model of CBT. This analytical model furthers the study of CBT as a strategy for sustainability.
Qualitative Impact Analysis of International Tourists and Residents’ Perceptions of Málaga-Costa Del Sol Airport
Authors: Caballero Galeote L. , García Mestanza J.
Published: June 2020

Air transport plays a key role especially in countries where tourism has a great impact on the economy. In Spain, the contribution made by this industry to GPD stands at EUR 119 billion, representing 11% of GDP. This case study focuses on the Málaga-Costa del Sol Airport due to the growth the city has experienced in recent years. The research examines the impacts of this infrastructure from the perceptions of residents and tourists. We conducted 638 questionnaires and 50 interviews with residents, and 165 questionnaires and 106 interviews with international tourists from August 2019 to January 2020. A qualitative thematic analysis was carried out using the NVivo Pro software. The findings indicate that residents value the ease of travel and employment generated by the airport. However, they are concerned about the environment impacts and mass tourism. For tourists, almost no negative impacts are recorded. Residents and tourists consider the existence of positive effects on other nearby cities of Andalusia. Conclusions have practical and theoretical implications for impact researches.
Analysis of Flood-Vulnerable Areas for Disaster Planning Considering Demographic Changes in South Korea
Authors: Lee Hye-Kyoung , Bae Young-Hoon , Son Jong-Yeong , Hong Won-Hwa
Published: June 2020

Regional demographic changes are important regional characteristics that need to be considered for the establishment of disaster prevention policies against climate change worldwide. In this study, we propose urban disaster prevention plans based on the classification and characterization of flood vulnerable areas reflecting demographic changes. Data on the property damage, casualties, and flooded area between 2009 and 2018 in 229 municipalities in South Korea were collected and analyzed, and 74 flood vulnerable areas were selected. The demographic change in the selected areas from 2000 to 2018 was examined through comparative analyses of the population size, rate of population change, and population change proportion by age group and gender. Flood vulnerable areas were categorized into three types through K-mean cluster analysis. Based on the analysis results, a strategic plan was proposed to provide information necessary for establishing regional flood-countermeasure policies.
Maladaptive Perfectionism and College Adjustment of International Students in Korea: A Moderated Mediation Model of Social Support
Authors: Lee Gina , Park Tae In , Cho Hyojin
Published: June 2020

Due to the increasing demand for international education, the number of international students in Korea has been rapidly increasing. Accordingly, well adjusting to college has been a main interest for both academic institutions and international students as it is key to their success. Previous studies have revealed that maladaptive perfectionism (MP) hampers the college adjustment (CA) of international students, yet little is known about its underlying mechanism. To fill in this gap, this study examined the mediating effect of acculturative stress (AS) in between maladaptive perfectionism and college adjustment; the moderating effect of social support (SS) in the relation between acculturative stress and college adjustment; and the moderated mediating effect of social support in the causal pathway from maladaptive perfectionism to acculturative stress to college adjustment. Results showed a partial mediating effect of acculturative stress, a moderating effect, and a moderated mediating effect of social support. This implies that social support is an essential factor that helps international students better adjust to the new collegiate environment by alleviating their stress caused by maladaptive perfectionism and acculturative stress.