bluuebunny/crossref_metadata_2025 huggingface dataset:
Multipath mitigation for GPS/Galileo/BDS-3 precise point positioning with overlap-frequency signals
Authors: Geng Jianghui , Zhang Honghai , Li Guangcai , Aoki Yosuke
Published: July 2024

The multipath effect is a major Global Navigation Satellite System (GNSS) error source due to its environment-dependent characteristic, which complicates its mitigation process for the high-rate determination of displacements. For instance, Sidereal Filtering (SF) and Multipath Hemispherical Map (MHM) require the observations spanning at least one full cycle of satellite orbit repeat period (e.g., ten days for Galileo navigation satellite system (Galileo) to reproduce the satellite geometry against ground stations. As a consequence, the practicability of SF and MHM is limited due to potential station-surrounding changes over a long period. In this study, we used the overlap-frequency signals on Global Positioning System (GPS) L1/L5, Galileo E1/E5a, and BeiDou-3 Navigation Satellite System (BDS-3) B1C/B2a to construct an interoperable MHM (i.e., MHM_GEC) across constellations to mitigate multipath more efficiently. We thus used 31 days of 1-Hz GPS/Galileo/BDS-3 data at 21 stations in Europe to compare this overlap-frequency MHM with those GNSS-specific MHMs (i.e., MHM_G for GPS, MHM_E for Galileo, and MHM_C for BDS-3), as well as SF. It is confirmed that the multipath effects on overlap-frequency signals are of a high spatial consistency across all GNSS. The mean reduction rate of applying MHM_GEC to GPS, Galileo, and BDS-3 carrier-phase residuals is 25%, 31%, and 28.5%, respectively, which are up to 25 percentage points higher than those of MHM_G, MHM_E, and MHM _C. Furthermore, the MHM_GEC constructed using 5 to 6 days of data can improve the positioning precision by 40%, outperforming the MHM_E, MHM_C, and SF using 10 days of data. Therefore, the interoperable MHM_GEC is more efficient in mitigating multipath effects for high-precision GNSS positioning.
Treatment of an Aggressive Gonadotroph Pituitary Neuroendocrine Tumor With 177Lutetium DOTATATE Radionuclide Therapy
Authors: Gandhi Chaitanya , Koumna Stella , Chik Constance
Published: July 2024

Aggressive pituitary neuroendocrine tumors (PitNETs) present significant morbidity, and multimodal therapies including surgery, radiotherapy, and medications are frequently required. Chemotherapy, particularly temozolomide, is often pursued for tumors that progress despite these treatments. Although peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin analogs is approved for the treatment of well-differentiated gastrointestinal neuroendocrine tumors, its use in aggressive PitNETs is limited. We describe the case of a 65-year-old man who presented with vision changes and hypopituitarism at age 33 secondary to a nonfunctioning gonadotroph PitNET. His initial treatment included a craniotomy followed by radiation therapy. With tumor regrowth, he required transsphenoidal surgeries at age 44 and age 52. At age 56, further tumor regrowth and a positive octreotide scan prompted treatment with long-acting octreotide for 1 year. Given absent tumor response, 12 cycles (4 treatment cycles and 8 maintenance cycles) of PRRT with 177Lutetium-DOTATATE were pursued. This resulted in partial response with significant tumor shrinkage. Notably, there was no tumor regrowth 40 months after treatment discontinuation. This is only the second report on the effectiveness of PRRT in patients with aggressive gonadotroph PitNETs. We also provide an overview of PRRT for PitNETs and describe clinical outcomes previously reported in the literature.
The Arduous Path Toward Equitable Access to Endocrinology Care
Authors: Romeo Giulio R , Caputo Tiziana , Stanescu Izabela W , Alkhaddo Jamil B
Published: July 2024

Multiple factors contribute to the widening gap between supply and demand of endocrinology services. In addition to the inadequate growth of the workforce, the inefficient utilization of endocrinologists’ expertise coupled with the rising prevalence of endocrine conditions has generated a crisis in access to specialty care. This mismatch is magnified in underserved communities and among certain racial/ethnic groups that carry a disproportionate burden of chronic diseases, like diabetes and osteoporosis, thus perpetuating the cycle of health disparities in vulnerable populations.

Reorienting the framework of endocrine care toward more effective and equitable access will require comprehensive changes in operational processes, system-based policies, and in the diversity of our workforce. Specifically, the progressive transition to outcome-driven, team-based models of care can extend endocrinology services beyond the traditional boundaries of in-office referrals and promote job satisfaction. Further, the implementation of policies that directly tackle structural determinants of health is a prerequisite to a more precise and equitable deployment of specialty care. In this view, the recruitment and professional growth of clinicians underrepresented in medicine along the career ladder, including leadership roles, is a key conduit to revitalize our field and to innovate the delivery of endocrine care across all communities.
Cap-related modifications of RNA regulate binding to IFIT proteins
Authors: Geng Jingping , Chrabaszczewska Magdalena , Kurpiejewski Karol , Stankiewicz-Drogon Anna , Jankowska-Anyszka Marzena , Darzynkiewicz Edward , Grzela Renata
Published: July 2024

All cells in our body are equipped with receptors to recognize pathogens and trigger a rapid defense response. As a result, foreign molecules are blocked, and cells are alerted to the danger. Among the many molecules produced in response to viral infection are interferon-induced proteins with tetratricopeptide repeats (IFITs). Their role is to recognize foreign mRNA and eliminate it from the translational pool of transcripts. In the present study, we used biophysical methods to characterize the interactions between the IFIT1 protein and its partners IFIT2 and IFIT3. IFIT1 interacts with IFIT3 with nanomolar binding affinity, which did not change significantly in the presence of the preformed IFIT2/3 complex. The interactions between IFIT2 and IFIT3 and IFIT1 and IFIT2 were one order of magnitude weaker. We also present kinetic data of the interactions between the IFIT protein complex and short RNA bearing various modifications at the 5′ end. We show kinetic parameters for interaction between the IFIT complex and RNA with m6Ammodification. The results show that the cap-adjacent m6Ammodification is a stronger signature than cap1 alone. It blocks the formation of a complex between IFIT proteins and m7Gpppm6Am-RNA much more effectively than other cap modifications. In contrast, m6A in the 5′UTR is not recognized by IFIT proteins and does not contribute to translation repression by IFIT proteins. The data obtained are important for understanding the regulation of expression of genetic information. They indicate that 2′-Oand m6Ammodifications modulate the availability of mRNA molecules for proteins of innate immune response.
Παρεμβάσεις ελαχιστοποίησης κινδύνου μετάδοσης COVID-19
Authors: Σαπουνάς Σπύρος
Published: July 2024

Η παρούσα διδακτορική διατριβή διενεργεί μια πολυδιάστατη ανάλυση αποτελεσματικών παρεμβάσεων για τον περιορισμό της διασποράς της COVID-19. Με βάση ένα ευρύ φάσμα επιστημονικής βιβλιογραφίας και ανάλυσης δεδομένων, η διατριβή αξιολογεί την αποτελεσματικότητα διαφόρων στρατηγικών με στόχο να εφοδιάσει τους πολιτικούς και τους αξιωματούχους δημόσιας υγείας με τα εργαλεία που απαιτούνται για τη διαφύλαξη της δημόσιας υγείας και την καθοδήγηση προς την αποφασιστική καταπολέμηση της μετάδοσης της νόσου. Στην αρχή αναλύθηκε η πιθανή εποχικότητα της δραστηριότητας του νέου κορωνοϊού SARS-CoV-2. Πολλοί αναπνευστικοί ιοί, συμπεριλαμβανομένων των κορωνοϊών, ακολουθούν εποχική δυναμική μετάδοσης. Η ανάλυση των κοινωνικών και περιβαλλοντικών μηχανισμών της εμφάνισης του SARS-CoV-2 κατά την πρώτη χειμερινή περίοδο από την έναρξη της πανδημίας, παρέχει σημαντικές πληροφορίες για τον σχεδιασμό στοχευμένων παρεμβάσεων. Όπως για παράδειγμα ότι η πτώση της θερμοκρασίας τη νύχτα συνεπάγεται μεταφορά των νυχτερινών δραστηριοτήτων σε κλειστούς χώρους (ψυχαγωγίας) κυρίως για τους νέους 18–39 ετών. Προκύπτει λοιπόν ότι η μετατόπιση ψυχαγωγίας από εξωτερικούς σε εσωτερικούς χώρους κατά τη διάρκεια της ψυχρής περιόδου πρέπει να γίνεται σταδιακά και με τρόπο καλά ελεγχόμενο. Οι παρεμβάσεις που εφαρμόστηκαν στις Μονάδες Φροντίδας Ηλικιωμένων (ΜΦΗ) αλλά και σε κλειστά εργασιακά περιβάλλοντα, υπογραμμίζουν την κρίσιμη σημασία της προστασίας των ευάλωτων πληθυσμών. Μέσω της εφαρμογής αυστηρών μέτρων ελέγχου των μολύνσεων, συχνών τεστ και εκστρατειών εμβολιασμού εντός αυτών των μονάδων, η διασπορά της COVID-19 μεταξύ των ηλικιωμένων και των εργαζομένων μειώθηκε σημαντικά. Η χρήση αυτοδιαγνωστικών τεστ κατά τη διάρκεια της πανδημίας ανέδειξε την ανάγκη υλοποίησης περισσότερων αυτοδιαγνωστικών τεστ σε πανδημίες. Επιπλέον, η υψηλή μεταδοτικότητα των αναπνευστικών νόσων υπογραμμίζει την ανάγκη για γρήγορη και ευρεία δοκιμή για την αποτελεσματική περιορισμό των εξάρσεων. Με τη χρήση αυτών των τεστ, αποφεύχθηκαν 2.000 θάνατοι και 20.000 νοσηλείες όπως φάνηκε στη μελέτη μας. Με τη διεύρυνση της διαθεσιμότητας και της χρήσης των αυτοδιαγνωστικών τεστ, οι αρχές δημόσιας υγείας μπορούν να ενισχύσουν τις προσπάθειες για την έγκαιρη ανίχνευση, τη διενέργεια στοχευμένων παρεμβάσεων και την τελική μείωση των επιπτώσεων των αναπνευστικών πανδημιών.
Εγκλήματα κατά των συγκοινωνιών
Authors: Μπαστουνάς Γεώργιος
Published: July 2024

Στην παρούσα μελέτη επιχειρείται η ενασχόληση με τα εγκλήματα κατά των συγκοινωνιών που καταλαμβάνουν τις διατάξεις των άρ. 290-292 ΠΚ και συνιστούν την πρώτη ενότητα του 14ου κεφαλαίου του ΠΚ. Τα συγκεκριμένα εγκλήματα μπορούν να καταταχθούν σε δύο βασικές κατηγορίες, ήτοι (α) στα εγκλήματα της διατάραξης της ασφάλειας των συγκοινωνιών (άρ. 290-291 ΠΚ) και (β) στο έγκλημα της παρακώλυσης των συγκοινωνιών (άρ. 292 ΠΚ). Η μελέτη αποτελεί την πρώτη συστηματική προσπάθεια ανάλυσης των κρίσιμων εγκλημάτων, τα οποία μετά την ισχύ του νέου Ποινικού Κώδικα (ν. 4619/2019) απέκτησαν ένα αναβαθμισμένο περιεχόμενο με τις κρίσιμες διατάξεις να υφίστανται μία ριζική αναβάθμιση. Το γεγονός αυτό, αλλά και η εμφάνιση αυτών των εγκλημάτων σε μία πληθώρα περιπτώσεων πολύνεκρων δυστυχημάτων καθιστά αναγκαία την ερμηνευτική αποσαφήνισή τους, με σκοπό τόσο να αποτελέσει ένα χρήσιμο εργαλείο για τον θεωρητικό, τον εφαρμοστή, αλλά και τον νομοθέτη. Η συγκεκριμένη έρευνα αποσκοπεί στην εκτενή ανάλυση των διατάξεων με την επισήμανση κομβικών ζητημάτων που ανακύπτουν κατά την ερμηνεία και την εφαρμογή τους. Ως εκ τούτου, επιχειρείται η θεωρητική ερμηνεία κρίσιμων όρων που έτυχαν περιορισμένης ή ελλιπούς αναζήτησης από τη θεωρία και τη νομολογία, αλλά και η καταγραφή και ο σχολιασμός των νομολογιακών τάσεων που σχετίζονται με τα αφορώμενα ζητήματα. Είναι σημαντικό να υπογραμμισθούν οι δύο βασικοί πυλώνες της εργασίας. Ο πρώτος σχετίζεται με την αναφορά στο νέο και ισχύον νομοθετικό καθεστώς που αναδιάρθρωσε τα παρόντα εγκλήματα, με τη σαφή επισήμανση των αλλαγών, την κριτική τους αποτίμηση και την υποστήριξη προτάσεων βελτίωσης των διατάξεων, και ο δεύτερος με τη διαρκή σύγκριση σε όλα τα κεφάλαια με τις θέσεις που έχουν υποστηριχθεί σε άλλες χώρες, και συγκεκριμένα στη Γερμανία, την Αγγλία και την Ελβετία.
Η φυσική αγωγή και η συμβολή της στην ανάπτυξη της πολυπολιτισμικής προσέγγισης μαθητών δημοτικού σχολείου
Authors: Μαντζιούκας Παναγιώτης
Published: July 2024

Εισαγωγή: Το ελληνικό σχολικό περιβάλλον της πρωτοβάθμιας εκπαίδευσης έχει μετεξελιχθεί σε ένα πολυπολιτισμικό χώρο, όπου η έντονη κινητικότητα των πληθυσμών τα τελευταία έτη, προς τη χώρα ήταν ιδιαίτερα έντονη. Αποτέλεσμα αυτής της κοινωνικό/γεωπολιτικής εξέλιξης ήταν το σύγχρονο ελληνικό δημοτικό σχολείο να χαρακτηρίζεται για την διαπολιτισμικότητά του. Ειδικότερα, το μάθημα της Φυσικής Αγωγής αποτελεί ένα εκπαιδευτικό πεδίο που επηρεάστηκε από τη μεταβολή αυτή με την ένταξη στο σχολικό περιβάλλον μαθητών με πολυπολιτισμικό προφίλ. Σκοπός: Ο κύριος σκοπός της παρούσας διατριβής είναι η ανάδειξη των στάσεων και των απόψεων εκπαιδευτικών φυσικής αγωγής της πρωτοβάθμιας εκπαίδευσης και δασκάλων που υπηρετούν σε ολιγοθέσια σχολεία αναφορικά με ζητήματα πολυπολιτισμικότητας-διαπολιτισμικότητας - πολιτιστικού πλουραλισμού (ΠΠ) και πολιτισμικής ετερότητας (ΠΕ) - και τη συμβολή του μαθήματος της Φυσικής Αγωγής στην ανάπτυξη της πολυπολιτισμικής προσέγγισης μαθητών του σύγχρονου Ελληνικού Δημοτικού Σχολείου.Μέθοδος: Διττή έρευνα, επισκόπησης και παρατήρησης, πραγματοποιήθηκε με τη χρήση του ερωτηματολόγιου «Ερωτηματολόγιο αξιολόγησης απόψεων και στάσεων εκπαιδευτικών φυσικής αγωγής ως προς την πολυπολιτισμικότητα και την πολιτισμική ετερότητα, ΕΑΑΣΕΦΑ», της Κλίμακας Αυτοαξιολόγησης «Κλίμακα Αυτοαξιολόγησης Συμπεριφοράς Μαθητή/τριας, ΚΑΣΜ» και της Κλίμακας Παρατήρησης «Κλίμακα Παρατήρησης Συμπεριφοράς Μαθητή/τριας, ΚΠΣΜ». Η στατιστική ανάλυση των δεδομένων πραγματοποιήθηκε με το πρόγραμμα Στατιστικής Ανάλυσης IBM SPSS 21.0. Το δείγμα της έρευνας αποτελούνταν από781 εκπαιδευτικούς στους οποίους διενεργήθηκε το ερωτηματολόγιο ΕΑΑΣΕΦΑ, από 1045 μαθητές Ε΄ και ΣΤ΄ τάξης δημοτικού σχολείου στους οποίους διενεργήθηκε έρευνα με την Κλίμακα ΚΑΣΜ και από 46 μαθητές Ε΄ και ΣΤ΄ τάξης διαπολιτισμικών δημοτικών σχολείων στους οποίους διενεργήθηκε παρατήρηση με την Κλίμακα ΚΠΣΜ.
Transformative Learning as a Part of Living Theory: A Constant Evolution of Transformative Learning Theory in Lifelong Education
Authors: Misawa Mitsunori
Published: July 2024

Transformative Learning Theory is one of the major adult learning theories. It has gained significant attention due to its potential to revolutionize education and personal development. Although its popularity has made it branch out from the adult learning theories as a distinct theory with unique characteristics and utilizations, the field of Transformative Learning has fallen into its own disorienting dilemma. The field of Transformative Learning is now in a critical phase as a field of study where it needs to refine itself to better develop its identity and grow. In this article, I will respond to the six questions regarding Transformative Learning Theory and the field of Transformative Learning that the editorial team of the journal asks.
Transformative Learning in the Era of Post-Reflexivity
Authors: Fabbri Loretta
Published: July 2024

This article collects over 20 years of studies, encounters, and conversations around Transformative Theory and reflective practices, which have characterized my identity as a scholar and the Italian Transformative Learning Network’s identity. I am going to trace the main challenges that, starting from practice-based studies and situated learning theory, have established the foundation for our research group's discussion on Transformative Learning. I am going to venture into open dialectical arenas with new perspectives that have amazed and questioned me. The posthuman, sociomateriality, and post-qualitative inquiry interrogate some of the foundations of Transformative Theory and urge us to create a creative space to share challenging epistemic constructions.
Transformative learning theory, theoretical field or metatheory?
Authors: Kokkos Alexis
Published: July 2024

In the present response to the journal’s survey, I mainly discuss the present state of affairs of the transformative learning (TL) theoretical framework. I argue that, on the one hand, various theoretical contributions have significantly expanded and enriched Jack Mezirow’s initial conceptualization. On the other hand, the ever-increasing theoretical views led to the fragmentation of the theoretical field and to uncertainty as regards its components and terminology. Accordingly, I claim that a collective metatheoretical work that should attempt to seek for points of agreement and synthesize the various perspectives might favor the development of a more integrated TL theoretical framework.
Influência das embalagens e dos preços nas decisões de compra de barras de chocolate
Authors: Lopes da Silva Elaine Aparecida , Fernandes Ferreira Lissa Valéria , Cavalcante Dias Maria Carolina , Torelló Navarro Marina
Published: July 2024

O objetivo do estudo é analisar a influência da embalagem e dos preços nas decisões de compras de barras de chocolate. A coleta de dados deu-se a partir de entrevistas semiestruturadas, técnicas de observação, test duplo cego e questionário, com uma amostra de 294 consumidores espanhóis. Os resultados indicam que as embalagens apresentam um papel estratégico para as marcas gerando experiência de consumo de produto, melhorando a experiência no ponto de venda, e favorecendo a percepção de qualidade. Além disso, observou-se que um desenho adequado de preços pode favorecer decisões mais rápidas, e disposição do consumidor em pagar preços premium.
(Nie)widzialne wyzwania, wirtualne rozwiązania: technologia VR a odnajdywanie się w przestrzeni przez osoby z niepełnosprawnością wzroku
Authors: Cząstkiewicz Aleksandra
Published: July 2024

Samodzielne przemieszczanie się jest jednym z przejawów autonomii, ważnej m.in. dla samopoczucia czy przekonania o własnej sprawczości danej jednostki. Pytanie, czy kreujemy rzeczywistość, nadal pozostaje otwarte, ale niewątpliwy jest fakt, że działamy w pewnej interakcji ze środowiskiem, a przy użyciu technologii chcemy doświadczenie obecności w świecie rozszerzać i modyfikować, co zresztą dzieje się nieuchronnie. Celem tekstu jest próba eksploracji dostępnych sposobów odnajdywania się w przestrzeni osób z niepełnosprawnością wzroku i przywołanie refleksji na ten temat. W artykule przedstawiona zostanie definicja wirtualnej rzeczywistości (VR), a także koncept echolokacji. Autorka tekstu podejmuje również próbę opisania relacji między osobą z niepełnosprawnością a środowiskiem postrzeganym przestrzennie z uwzględnieniem tego, jak środowisko VR może wpływać na umiejętności postrzegania informacji przestrzennych i odnajdywania się w otoczeniu.
Acessibilidade comunicativa: palavra-chave para um jornalismo democrático e cidadão.
Authors: Letícia Wobeto Samara , Borelli Viviane , Moraes Romero Luan
Published: July 2024

Este artigo faz parte de uma pesquisa maior desenvolvida como requisito para conclusão do curso de Jornalismo, que objetivou a construção de uma ferramenta de indicadores de qualidade para a acessibilidade comunicativa no jornalismo. A discussão teórica se centra nos entrelaçamentos entre o jornalismo, a democracia e a cidadania em sua relação com a temática. São argumentos centrais a ausência de acessibilidade nas práticas jornalísticas, o que a torna uma lacuna, e as formas estigmatizadas de representação dos públicos com deficiência. O desconhecimento de jornalistas acerca das tecnologias assistivas e formas de acessibilizar também é parte do problema. Argumentase que não é possível ter um jornalismo verdadeiramente democrático e cidadão sem acessibilidade comunicativa. Para atingir o objetivo do artigo, usa-se a revisão bibliográfica (Barrichello, 2016) para delimitar campos teóricos e normativos. Os últimos são guias, legislações e orientações de acessibilidade para a comunicação tanto em nível nacional quanto internacional, que permitem, junto às teorias do jornalismo e da acessibilidade, estabelecer critérios para a construção dos indicadores. Com os mesmos redigidos, eles são testados nos sites de dois veículos jornalísticos, com entrevistas semi-abertas (Gil, 2008) de usabilidade com pessoas com deficiência, e outras com os editores dos veículos analisados. Conclui-se que a acessibilidade não é prioridade destes veículos jornalísticos, o que se evidencia pela baixa pontuação e pelos registros de ausências de tecnologias assistivas, da cultura jornalística que não prioriza valores de acessibilidade e do desconhecimento das melhores formas de incorporar a mesma em uma rotina produtiva.
Inclusión discursiva de mujeres con discapacidad y el potencial del periodismo para producir representaciones emancipadoras.
Authors: Araujo de Freitas Thais , Silva Terezinha
Published: July 2024

A partir de un encuadre teórico en los derechos humanos, vulnerabilidad e interseccionalidad, el artículo reflexiona sobre cómo el silenciamiento histórico de las mujeres y especialmente de las mujeres con discapacidad, en la sociedad y en la comunicación mediática les restringe el pleno ejercicio de derechos. El objetivo es comprender en qué medida la inclusión de las perspectivas de las mujeres con discapacidad en los relatos periodísticos puede contribuir a la construcción de representaciones más humanizadas y emancipadoras, y garantizarles una posición en cuanto que sujetos de sus propios discursos e historias, en lugar de someterlas a la condición de objetos de las noticias. Este artículo está estructurado como un ensayo, basado en investigación bibliográfica para desarrollar el argumento sobre los límites aún presentes en los medios tradicionales para incorporar las voces, temas y perspectivas de las personas con discapacidad. Ejemplos de iniciativas periodísticas con perspectiva feminista e interseccional, identificados en una investigación exploratoria del contexto brasileño, ayudan a evidenciar algunos aspectos del potencial de la inclusión discursiva de las mujeres con discapacidad en relatos periodisticos para problematizar valores capacitistas y excluyentes que sostienen las representaciones vigentes y obstaculizan el debate sobre sus derechos
El periodismo como medio de fijación término-conceptual: el caso de El País durante la cobertura de las revueltas árabes de 2011.
Authors: Assif Mohamed
Published: July 2024

Ante un acontecimiento de resonancia internacional, el periodismo se erige en catalizador e, incluso, acuñador de conceptos y percepciones. Las revueltas árabes de 2011 presentan el paradigma de fijaciones términoconceptuales en la prensa. La expresión Primavera Árabe es, por antonomasia, el ejemplo más evidente de tal acuñación conceptual, amén de otras cuestiones de mayor sensibilidad para los lectores como la subida al poder del «islam político» o la ensalzada figura de Mohamed Bouazizi, el vendedor ambulante quemado a lo bonzo el 17 de diciembre de 2010 por su situación socioeconómica. Sin embargo, investigadores varios desmitifican la imagen de Bouazizi y rebautizan las revueltas como otoño o invierno árabe. Esta investigación indaga las terminologías y las locuciones prevalecientes en los géneros informativos de la sección internacional de El País durante el tratamiento de las revueltas árabes de 2011 para lo que se realiza un análisis sobre 1200 textos. De la mano de un método mixto –cuantitativo y cualitativo– se examinan los conceptos que este diario utiliza con frecuencia para condicionar la agenda pública sobre este acontecimiento internacional. Los resultados indican que El País se ha hecho eco, aunque tardíamente, del neologismo: Primavera Árabe. Esta demora en incluirlo dentro de la nomenclatura definitoria de tales sucesos se atribuye a que la cabecera madrileña opte por aguardar un atisbo de la consolidación de los logros obtenidos en Túnez y Egipto, así como su contagio a otras naciones para poder catalogar estos hechos como una Primavera Árabe.
Disclosing Delivery Performance Information When Consumers Are Sensitive to Promised Delivery Time, Delivery Reliability, and Price
Authors: Leng Mingming , Becerril-Arreola Rafael , Parlar Mahmut , Ferguson Mark
Published: July 2024

Problem definition: We investigate how the characteristics of consumers and a service firm influence the firm’s optimal pricing and promised delivery-time decisions as well as the optimal investment in the quality of delivery reliability information available to consumers. Methodology/results: We use utility, queuing, and choice modeling theories to model consumers’ behavior and to find solutions to the firm’s profit maximization problem. Managerial implications: The optimal strategy is to disclose either error-free delivery reliability information or no information at all. We also delineate conditions for each of the two strategies to dominate.

Funding: This research was supported by the General Research Fund (GRF) of the Hong Kong Research Grants Council under Research Project LU13500822.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.0223 .
interrogaciones a las materialidades y metas político-pedagógicas de lo escolar, nacidas en la práctica del filosofar con niños y niñas
Authors: Shapiro Carmina
Published: July 2024

Las prácticas educativas escolarizadas se desarrollan sobre la base de una serie de directrices que fueron consolidando el formato escolar como lo conocemos hoy. Las materialidades que utilizamos para desplegar las actividades escolares y los fines o metas pedagógico-políticas con los que las orientamos forman parte de las mencionadas directrices. En este trabajo, tomando base en las experiencias cultivadas en escuelas en Ronda de Palabras (Argentina), una formación basada en Filosofía con Niños, queremos plantear una discusión con esos dos grandes supuestos educativos que parecen ser inamovibles cuando pensamos en la escolaridad más convencional. En una primera parte, presentaremos un análisis crítico de las novelas filosóficas escritas por Matthew Lipman para la implementación de su proyecto de Filosofía para Niños (FpN). Si bien esta es una discusión específica del campo de la enseñanza de la filosofía, creemos que algunos de sus puntos pueden ser generalizados para pensar las relaciones pedagógicas que construimos con las materialidades sobre las que basamos nuestras prácticas educativas, y sus implicancias políticas. En la segunda parte, analizaremos algunos aportes que hacen las lecturas más críticas de la FpN de Lipman para pensar acerca de las metas pedagógico-políticas implícitas en ella, y en qué medida ponen en jaque, o bien aceptan tácitamente, las supuestas en la escolaridad convencional. Nuestro objetivo general es poner en tensión aquellas ideas que orientan y organizan las intervenciones pedagógicas en un determinado sentido, atendiendo a las ineludibles  relaciones que tejen política y educación juntas.
Infecção natural por Trypanosoma sp. em cão na cidade de São Luís, MA – relato de caso
Authors: Santos Juciê Leite dos , Santos Rayane Leite dos , Santos Raquel Leite dos , Passos Victória Hannah Araújo de Almeida , Leite Jeane Vieira
Published: July 2024

A tripanossomíase é uma antropozoonose causada por protozoários flagelados do gênero Trypanossoma, o cão apresenta importante papel na cadeia de transmissão dessas doenças, pois além de hospedeiro e reservatório desenvolve sintomas semelhantes aos humanos, seus principais representantes são o T.cruzi e o T. evansi responsáveis respectivamente pela tripanossomíase americana, também chamada de Doença de Chagas e a “surra”, conhecida nos equinos como “mal das cadeiras”. A transmissão da Doença de Chagas ocorre por meio de vetoração biológica através de insetos hematófagos do gênero Triatoma, conhecidos popularmente como barbeiros. Um canino foi atendido em uma clínica veterinária na cidade de São Luís, MA, apresentando surgimento súbito de dispneia, anorexia, adipsia, letargia e fraqueza progressiva. No exame físico foi constatada hipocoloração das mucosas, baixo índice de escore corporal e abaulamento do abdômen com consequente sensibilidade à palpação. Na análise hematológica foi detectada anemia normocítica e normocrômica com sinais de regeneração, linfocitose e desvio à esquerda, com presença de neutrófilos bastonetes. No esfregaço sanguíneo foram encontradas estruturas compatíveis com protozoários flagelados do gênero Trypanosoma spp. Apesar do rápido diagnóstico e início do protocolo terapêutico, o animal foi a óbito no mesmo dia em que foi internado. Este trabalho teve como objetivo relatar o primeiro caso de tripanossomíase em um cão na cidade de São Luís, MA.
Perfil sociodemográfico e de saúde do idoso e do cuidador – estudo de associação com o nível de dependência do idoso com deficiência intelectual
Authors: Lopes Elaine Cristina Costa , Nascimento Júnior José Roberto Andrade do , Oliveira Daniel Vicentini de
Published: July 2024

O objetivo deste estudo foi analisar se os fatores sociodemográficos e de saúde do cuidador e do idoso estão associados com o nível de dependência do idoso com deficiência intelectual. Trata-se de um estudo epidemiológico quantitativo, analítico, observacional e transversal realizado com 605 cuidadores de idosos com deficiência intelectual, pertencentes a Associação de Pais e Amigos dos Excepcionais (Apae) do Estado do Paraná, Brasil. Utilizamos um questionário sociodemográfico e de saúde para caracterização dos idosos e de seus cuidadores. O nível de dependência do idoso foi avaliado por meio da Medida de Independência Funcional (MIF). A análise dos dados foi realizada pelo teste de Qui-quadrado de Pearson (p<0,05). Verificamos diferença significativa entre os grupos no sexo do cuidador (p = 0,035) e na percepção de saúde do cuidador (p = 0,001). Percebemos alta frequência de idosos com dependência modificada de até 50% das tarefas que eram atendidos por cuidadores do sexo feminino (87,1%). Notamos alta frequência de idosos com dependência modificada de até 50% das tarefas que utilizavam mais medicações contínuas (p = 0,001) e com classificação mais grave no CID (p = 0,001). Pode-se concluir que, na percepção dos cuidadores(as), o nível de dependência do idoso está diretamente associado com a utilização de medicamentos e classificação grave no CID. Destaca-se também que o maior grau de independência dos idosos se associou com a melhor percepção da saúde dos cuidadores.
Periapical mucoepidermoid carcinoma: a case report with review for diagnosis and insights for dental rehabilitation
Authors: Brazao-Silva Marco Tullio , Matos Rafaella Almeida , Carvalho Lidylara Lacerda Araújo , Fonseca Larissa Lopes , Durães Cristina Paixão , Cardoso Cláudio Marcelo , Guimarães Douglas Magno
Published: July 2024

Periapical radiolucent lesions may represent a challenge in daily clinical practice because many cystic lesions and tumors sometimes surround teeth with compromised pulp. In this paper, we have shown an uncommon manifestation of mucoepidermoid carcinoma, firstly due to its intraosseous involvement and secondarily to involve the maxillary bone around the apex of molar teeth without pulp vitality on clinical tests. An incisional biopsy was the goal of this diagnosis. The mucous and epidermoid cells lining a cystic cavity, and the marginal minor salivary glands also showing proliferative foci of these tumoral cells, led to the diagnosis of mucoepidermoid carcinoma on histopathology. A respective approach was made as primary treatment, which resulted in a bucconasal communication. An obliterating removable prosthesis was conducted over the office approach, significantly improving speech and swallowing as shown. The discussion pointed out here highlights the case and the literature hot topics for diagnosis of periapical radiolucencies, objectifying to guide the clinicians reviewing the current state of the art. The structured diagnostic approach used here and illustrations of the new case are suitable to achieve this objective.
Activities of living, 7: personal cleansing and dressing
Authors: Peate Ian
Published: July 2024

Personal cleansing and dressing are integral components within the broader framework of the activities of living. Understanding how and why these activities are essential for maintaining hygiene, promoting health and fostering socio-psychological wellbeing will help the healthcare assistant (HCA) and assistant practitioner (AP) recognise their influence on an individual's overall quality of life. Developing and addressing the factors that may affect an individual's ability to conduct their own personal cleansing and dressing are key for the promotion of independence and wellbeing.
Living with inflammatory bowel disease: a modified photovoice study of adolescent mental health
Authors: Pineau Olivia N , Tripp Dean A , Kelly Alexandra , Mulder Daniel
Published: July 2024

Background:

Inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is a chronic condition involving inflammation of the gastrointestinal tract. Adolescents with IBD are 4.6 times more likely to experience depression and anxiety than healthy peers.

Aims:

The primary purpose of this research was to understand the lived experiences of adolescents diagnosed with IBD.

Methods:

Adolescents aged 16–18 years were recruited to complete an online survey, followed by a photovoice component that included the collection of images and participation in an interview.

Results:

Thematic analysis revealed six key themes: the importance of social support networks in managing the challenges of IBD, the positive impact of maintaining a positive outlook on life, strategies for taking control of and coping with the impact of IBD, the interplay between physical pain and the psychological toll of the disease, the various limitations imposed by IBD on daily life and the challenges posed by others’ lack of awareness and understanding of the condition.

Conclusions:

Adolescents with IBD experience disease-related factors that impact their wellbeing. Attention to these factors from nurses, doctors, caregivers and peers can help optimise their mental health and wellbeing.
Analysis of causes for revision in unicompartmental knee arthroplasty
Authors: Tripathy Sujit Kumar , Pradhan Siddharth Satyakam , Khan Shahnawaz , Patel Hursch
Published: July 2024

The study by Zhao et al identifies the factors leading to the failure of unicompartmental knee arthroplasty (UKA) in their patients. These factors include substandard suturing of the wound, the presence of osteophytes and intra-articular loose bodies causing impingement, premature loosening of the tibial component, choosing unsuitable patients for the procedure, dislocation of the movable insert, and damage to the anterior cruciate ligament and medial collateral ligament. The findings suggest that employing the correct surgical techniques and indications is essential for successful outcomes in the UKA.
Acute macular neuroretinopathy following COVID-19 infection: Three case reports
Authors: Bi Chao , Huang Chun-Mei , Shi Ye-Qiang , Huang Chao , Yu Tao
Published: July 2024

BACKGROUND

During the Coronavirus disease 2019 (COVID-19) pandemic, a notable increase in acute macular neuroretinopathy (AMN) cases was observed. This study aimed to investigate the potential association between AMN and COVID-19 by examining 3 cases in China.

CASE SUMMARY

The first case involved a 30-year-old man who presented with progressive vision loss following a COVID-19 infection. Optical coherence tomography (OCT) and near-infrared imaging identified hallmark AMN lesions, hyperreflective disruptions within the outer plexiform layer, and hyporeflective anomalies in the ellipsoid zone, leading to an AMN diagnosis. Despite partial visual recovery, OCT angiography (OCTA) revealed persistent microvascular changes, specifically a decreased vascular density in the deep capillary plexus. The second case was a 24-year-old woman who experienced blurred vision and exhibited bilateral cotton-wool spots on fundus examination post-COVID-19. Imaging confirmed the presence of AMN along with paracentral acute middle maculopathy (PAMM). Follow-up OCTA found a progressive reduction in vascular density, indicating ongoing microvascular compromise. The third case was a 28-year-old woman who reported sensations of occlusion in her right eye following a COVID-19 infection. Imaging confirmed both AMN and PAMM, revealing similar decreases of microvascular density on OCTA despite a significant improvement in visual acuity. We noted that all 3 patients had received the COVID-19 vaccine prior to the appearance of symptoms.

CONCLUSION

The findings highlight the diagnostic utility of advanced ocular imaging in detecting AMN in COVID-19 patients and the importance of comprehensive eye examinations.
Scaling New Depths: Innovations in Fish Collagen Extraction and Biomedical Frontiers Explored
Authors: Chandrasekaran Yuvashree , S Jagadeeswari , Dakshinamoorthi Balakumaran Manickam , Sri D Rushika , Sharma B Kiran
Published: July 2024

ABSTRACT: Collagen is a fibrous protein commonly found in the bodies of human and other animals. It is referred to be the most abundant protein which comprises 30% of animal’s overall protein. It is broadly used in diverse applications such as food, pharmaceutical, biomaterials, cosmetics, and biomedical industries. Fish waste is one of the cost-effective sources of collagen. The increasing adoption of marine-based and freshwater-based collagen is driven by their distinctive properties, which include advantages over mammalian-based collagen. These advantages encompass the absence of disease transmission risks, freedom from religious restrictions, cost-effective production, biocompatibility, and enhanced absorption within the human biological system. This review provides an overview of recent research regarding the extraction of collagen from marine and freshwater sources, with a specific focus on fish by-products. It encompasses subjects including the primary sources of fish collagen, pretreatment of fish materials, extraction techniques, collagen characterization, and its wide-ranging applications. More particularly, the study focuses at the procedures used to extract fish collagen, with an emphasis on isolating acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC). Likewise, the fish derived collagen’s application in biomedical engineering such as drug delivery systems, tissue engineering, therapeutic applications and cosmetic industry is summarized.
Control of Small GTPase Ras Using a Calmodulin-based Ionochromic Nanodevice
Authors: Zhang Ziyun , Sabek Yassine , Maruta Shinsaku
Published: July 2024

ABSTRACT: The small GTP-binding protein, HRas, is a switch-like molecule that plays an important role in the regulation of many cell processes. It is activated by binding to GTP and is inactivated when GTP is hydrolyzed to GDP. Ras has two accessory factors, guanine accelerate protein (GAP) and guanine nucleotide exchange factor (GEF), which facilitate its switching function by accelerating GTP hydrolysis and GDP/GTP exchange. Calmodulin (CaM) is a crucial signaling and regulatory molecule involved in many calcium-dependent processes. In the calcium-bound state, CaM binds tightly to the M13 peptide and IQ motif. Because there are no reports using CaM as an ionochromic switch system, CaM was used here to artificially control Ras. An HRas fusion protein with M13 (M13-HRas) was expressed using an established Escherichia coli expression system. M13-HRas showed 73% ion-regulation when the regulatory factors GAP and GEF were present. The CaM-bound state inhibited the interaction between M13-HRas and GST-Raf while maintaining a similar GTPase activity regulation ratio. Finally, the inhibition of CaM binding between M13-HRas and two accessory factors was confirmed. Thus, modifying the G protein functional site with M13 enabled ionochromic control of G protein function with CaM, which has implications for cancer therapy.
Exploring Machine Learning Methods for Developing a Predictive System for Parkinson's Disease
Authors: Das Sumit , Saha Tanusree , Nath Ira , Mondal Dipansu
Published: July 2024

ABSTRACT: The Integration of Machine Learning (ML) techniques holds significant promise in addressing challenges across various sectors, particularly within healthcare and biomedical fields. In this study, we focus on leveraging ML methodologies to address the longstanding issues surrounding the prediction and treatment of Parkinson's Disease (PD). PD prediction has historically suffered from inaccuracies and inconsistent treatments. Our research aims to mitigate these challenges by developing a predictive system tailored specifically to PD datasets. To achieve this, we systematically explore various ML algorithms for binary classification tasks, comparing their efficacy in predicting PD. By analyzing and comparing the performance of these algorithms, we aim to establish a robust pathway for accurately examining and diagnosing PD, thereby reducing discrepancies and associated risks. Our findings underscore the importance of employing ML techniques in developing effective decision support systems for PD prediction. By synthesizing results from multiple algorithms, our study not only contributes to filling existing research gaps but also provides actionable insights for the development of advanced medical applications. Overall, this research offers a comprehensive evaluation of ML approaches in the context of PD prediction, highlighting their potential to revolutionize diagnostic processes and improve patient outcomes. Our work not only enhances our understanding of PD but also underscores the transformative impact of ML in addressing complex medical challenges.
Isolation and Characterization of Aeromonas taiwanensis Strain for Simultaneous Production of Cellulase, Amylase, Pectinase, and Protease Enzymes
Authors: Gupta Supriya , Tanveer Aiman , Dwivedi Shruti , Yadav Kanchan , Morya Vivek Kumar , Yadav Dinesh
Published: July 2024

ABSTRACT: A study was conducted to discover a novel microorganism capable of producing multiple enzymes with industrial applications. Bacterial isolates were screened from a soil sample collected from a wood-decaying area, and their ability to produce various enzymes of industrial significance was evaluated. Among the 100 screened bacterial isolates, the strain GCEL-BGb85 was identified as Aeromonas taiwanensis through 16s RNA sequencing. Further screening revealed that this microorganism could produce cellulase, pectinase, protease, and amylase enzymes. The strain was set up for enzyme production, and the enzyme activity levels for cellulase, amylase, pectinase, and protease were 0.071, 0.201, 0.202, and 0.152 U/ml, respectively. All four enzymes demonstrated optimal activity at 40°C with a distinct pH. The zymogram analysis confirmed the presence of these enzymes in the isolated bacterial strain. As all the enzymes isolated from this strain are industrially significant, the application of the cell-free extract containing all these enzymes was evaluated at a laboratory scale for its potential use in industrial applications. The enzyme cocktail demonstrated its utility in the retting of fibers, effectively removing blood and egg yolk stains and extracting fruit juices and oil. The enzyme extract was also found to be useful in sustainable waste management.
Evaluation of Bioremediation Potential of Two Commercial Probiotics for Cr (VI): An In vitro Study
Authors: Goyal Pragya , Belapurkar Pranoti , Kar Anand
Published: July 2024

ABSTRACT: Chromium, in its hexavalent form (Cr (VI)), is a highly toxic and a carcinogenic heavy metal, which is released in the environment largely due to anthropogenic activities. Studies have reported that microorganisms especially probiotics may have the potential to reduce its toxicity under in vitro as well as in vivo conditions. The aim of this study was to assess the effects of various factors on bioremediation potential of two probiotic species of genus Bacillus, B. coagulans and B. clausii for Cr (VI). The factors assessed were initial Cr (VI) concentration, temperature, pH and contact duration. Both organisms showed an exceptionally high Cr (VI) reducing capability from the surrounding media. B. coagulans showed maximum reduction of Cr (VI) at 8 ppm concentration; temperature 40oC; pH 9 and contact duration 48 hrs while for B. clausii these parameters were optimized to be 8 ppm of Cr (VI) concentration, temperature 30oC, pH 7 and contact duration 48 hrs. These results also indicated that the probable strategies adopted by the test microorganisms for bioremediation of Cr (VI) are biosorption and bioaccumulation. The observations were highly promising and therefore, B. coagulans and B. clausii appear to be ideal candidates for potential bioremediation of Cr (VI), in vivo.
Virtual High Throughput Screening of Marine Bacterial Metabolites for BACE1 Inhibition
Authors: Grewal Annu , Sheokand Deepak , Chauhan Raveena , Saini Vandana , Kumar Ajit
Published: July 2024

ABSTRACT: Alzheimer's disease is a neurodegenerative ailment reportedly caused by abnormal production or collection of amyloid-β peptides. Alzheimer-causing Aβ peptides are produced when amyloid precursor protein is cleaved by β-secretase-1 (BACE1). Previous failures in clinical trials of BACE1 inhibitors have invited studies with lesser side effects and better therapeutic efficacy. Marine bacterial metabolites have been used successfully as therapeutic options for many diseases and hence will be suitable to study for their potential as Alzheimer's disease therapeutics. The present work attempted to virtually screen marine bacterial metabolites by molecular docking studies against BACE1. A total of 2884 marine bacterial metabolites were retrieved from the Comprehensive Marine Natural Products Database and analyzed for drug-like properties, using Lipinski’s rules, ADMET profiling and binding affinities. Atabecestat was selected as the standard BACE1 inhibitor for our study. The initial screening using Lipinski’s rule selected 1357 compounds and further filtration using ADMET properties calculated 199 metabolites. Molecular docking studies against BACE1 resulted in 8 marine microbial metabolites echoside D (-9.9 kcal/mol), urdamycin N6 (-9.9 kcal/mol), echoside A (-9.7 kcal/mol), nocatrione A (-9.6 kcal/mol), nocatrione B (-9.5 kcal/mol), homoseongomycin (-9.4 kcal/mol), echoside B (-9.2 kcal/mol) and thioquinomycin A (-9.2 kcal/mol) having binding affinity higher than Atabecestat (-8.9kcal/mol).
Frog Heart
Authors: Baglio Joy Deva
Published: July 2024

Abstract: The Summer 2024 Issue. Ploughshares is an award-winning journal of new writing. Since 1971, Ploughshares has discovered and cultivated the freshest voices in contemporary American literature, and now provides readers with thoughtful and entertaining literature in a variety of formats. Find out why the New York Times named Ploughshares “the Triton among minnows.” The Summer 2024 Issue, guest-edited by Rebecca Makkai, features prose by Dur e Aziz Amna, Ramona Ausubel, Peter Mountford, Khaddafina Mbabazi, DK Nnuro, and more.
The Posthuman Body and Climate Crisis in Latin American Science Fiction Written by Women
Authors: Ginway M. Elizabeth
Published: July 2024

Abstract: Four Latin American women authors—Karen Chacek and Gabriela Damián Miravete of Mexico, and Roberta Spindler and Aline Valek of Brazil—address the current climate crisis in narratives that break down barriers between the human body and the environment. Their stories explore the absorption of elements of the natural world into the human body, suggesting an exchange of both physicality and consciousness. This merging of elements from the plant, insect, and animal realms with the human body is evocative of Donna Haraway's networked body and Bolívar Echeverría's codigofagia , that is, the mixing of diverse codes toward the creation of future societies or civilizational experiments. The texts combine the possibilities of science fiction with the grieving process for a damaged planet, but without essentializing either women or nature. Using Rosi Braidotti's concept of posthuman feminism and Stacy Alaimo's transcorporeality, this article suggests that this approach to climate change—through bodily transformation and transcendent consciousness—captures the resilience of Latin American culture.