bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of the Level of Training of the First Assistant on the Outcomes of Adolescent Idiopathic Scoliosis Surgery
Authors: Talathi Nakul S. , Flynn John M. , Pahys Joshua M. , Samdani Amer F. , Yaszay Burt , Lonner Baron S. , Miyanji Firoz , Shah Suken A. , Cahill Patrick J.
Published: April 2019

Background:

At academic medical centers, residents and fellows play an integral role as surgical first assistants in spinal deformity surgery. However, limited data exist on whether the experience level of the surgical assistant affects outcomes.

Methods:

We conducted a multicenter, multisurgeon study comparing perioperative and postoperative outcomes after adolescent idiopathic scoliosis (AIS) surgery for the same 11 surgeons who performed cases that were assisted by residents compared with cases that were assisted by fellows. Blood loss, operative time, duration of hospitalization, complication rates, Scoliosis Research Society (SRS)-22 questionnaire scores, and radiographic outcomes were compared between the 2 groups.

Results:

We evaluated outcomes for 347 surgical procedures; 118 cases were assisted by residents and 229 were assisted by fellows. Preoperative radiographic and demographic parameters were not different between the groups. The resident group had significantly more estimated blood loss than the fellow group (939 compared with 762 mL, p = 0.02). Otherwise, the perioperative characteristics were similar between the groups, including the volume of the autologous blood recovery system product that was transfused, the operative time, and the occurrence of intraoperative neuromonitoring changes. Postoperatively, the percentage correction of the Cobb angle, the number of levels that had been fused, the number of days until the discharge criteria had been met, and the rate of major complications were similar between the groups. At the 2-year follow-up, the overall and subdomain SRS-22 questionnaire scores were not different between the groups, except that patients in the resident-assisted group had slightly worse pain scores than those in the fellow-assisted group (4.3 compared with 4.5, p = 0.01).

Conclusions:

The first assistant’s level of training did not affect clinical or radiographic outcomes following AIS surgery.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Impact of Image-Derived Instrumentation on Total Knee Arthroplasty Revision Rates
Authors: McAuliffe Michael J. , Beer Benjamin R. , Hatch Joshua J. , Crawford Ross W. , Cuthbert Alana R. , Donnelly William J.
Published: April 2019

Background:

Computer navigation and image-derived instrumentation (IDI) are technology-based methods developed to improve outcomes and potentially reduce revision total knee arthroplasty (TKA). IDI refers to the use of manufactured, patient-specific surgical jigs. Conflicting reports exist on IDI-associated improvements in outcomes. The primary aim of the current study was to compare the rates of revision among TKA cases in which components were initially implanted with use of IDI, computer navigation, or neither of these methods (“other” TKA). The secondary aim was to determine whether the outcomes of IDI differed for specific subgroups.

Methods:

Data were obtained from the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) for the 3 TKA groups: IDI, computer-navigated, and other TKA. The study period was from the first IDI procedure recorded by the AOANJRR (April 2010) to December 31, 2016. The analysis was restricted to primary TKA cases undertaken for osteoarthritis and involving patellar resurfacing and the use of a cross-linked polyethylene insert. Subanalyses were performed to evaluate the effects of age, sex, implantation method, IDI manufacturer, prosthetic design, and prosthesis type on the rates of revision. Kaplan-Meier estimates of survivorship described the time to first revision. Hazard ratios (HRs, Cox proportional hazards models) with adjustment for age and sex were used to compare revision rates.

Results:

IDI was used in 5,486 primary TKA procedures. There was no significant difference among the groups in the cumulative percent revision (CPR) at 5 years: 3.3% (95% confidence interval [CI], 2.4% to 4.6%) for IDI, 2.4% (95% CI, 2.2% to 2.7%) for the computer-navigated group, and 2.5% (95% CI, 2.3% to 2.7%) for other TKA. Posterior-stabilized TKA with use of the IDI method had a significantly higher rate of revision at >3 months (HR, 1.45 [95% CI, 1.02 to 2.04]; p = 0.036), as did IDI TKA in the ≤65-year-old patient cohort (HR, 1.52 [95% CI, 1.10 to 2.09]; p = 0.010), compared with computer-navigated TKA. Patellar revision was significantly more likely in the IDI group.

Conclusions:

IDI TKA demonstrated no overall difference in early to mid-term revision rates compared with standard implantation methods. However, elevated rates of revision were seen with posterior-stabilized TKA, in patients ≤65 years of age, and for patellar revision, meaning that this method should be used with some caution and requires further study.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Revisiting the International Normalized Ratio (INR) Threshold for Complications in Primary Total Knee Arthroplasty
Authors: Rudasill Sarah E. , Liu Jiabin , Kamath Atul F.
Published: April 2019

Background:

Consensus guidelines recommend use of the international normalized ratio (INR) to predict the risk of perioperative bleeding in orthopaedic surgery. However, current recommendations for targeting an INR of <1.5 are based on studies across all surgical disciplines. This study examined the impact of the INR on perioperative bleeding, mortality, postoperative infections, length of hospital stay (LOS), and readmissions following primary total knee arthroplasty (TKA).

Methods:

We retrospectively reviewed the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database for adult patients who underwent primary TKA from 2010 to 2016. Patients for whom an INR had been recorded within 1 day before the surgery were stratified and analyzed for perioperative bleeding, mortality within 30 days, deep wound and superficial infections, LOS, and readmissions. Multivariable regressions were utilized to adjust for differences in demographics and comorbidities among INR groups.

Results:

Of 21,239 patients, 57.2% had an INR of ≤1.0; 38.1% had an INR of >1.0 to 1.25, 3.9% had an INR of >1.25 to 1.5, and 0.8% had an INR of >1.5. After adjustment, a progressively increased bleeding risk was found with an INR of >1.0 to 1.25 (odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.07 to 1.31, p = 0.001), an INR of >1.25 to 1.5 (OR = 1.29, 95% CI = 1.02 to 1.63, p = 0.033), and an INR of >1.5 (OR = 2.02, 95% CI = 1.29 to 3.14, p = 0.002) relative to an INR of ≤1.0. Patients with an INR of >1.5 were at increased risk for infection (OR = 5.34, 95% CI = 2.45 to 11.68, p < 0.001), but only patients with an INR of >1.25 to 1.5 were at increased risk for mortality (OR = 3.37, 95% CI = 1.31 to 8.63, p = 0.011) relative to those with an INR of ≤1.0. Overall and TKA-related readmission rates and LOS were significantly increased for patients with an INR of >1.25 to 1.5 or an INR of >1.5.

Conclusions:

An INR of >1.25 to 1.5 was associated with increased bleeding, infection, and mortality rates following TKA, and an INR of >1.5 was associated with increased bleeding and infection rates. Current INR target recommendations in consensus guidelines should be reconsidered.

Level of Evidence:

Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Osteoid Osteoma About the Hip in Children and Adolescents
Authors: May Collin J. , Bixby Sarah D. , Anderson Megan E. , Kim Young Jo , Yen Yi-Meng , Millis Michael B. , Heyworth Benton E.
Published: April 2019

Background:

The etiology of hip pain in pediatric and adolescent patients can be unclear. Osteoid osteoma (OO) about the hip in children has only been described in case reports or small studies. The present study assessed the clinical presentation and diagnostic course, imaging, and treatment approaches in a large cohort of pediatric cases of OO about the hip.

Methods:

Medical record and imaging results were reviewed for all cases of OO identified within or around the hip joint in patients <20 years old between January 1, 2003, and December 31, 2015, at a tertiary-care pediatric center. Demographic, clinical, and radiographic data were analyzed.

Results:

Fifty children and adolescents (52% female; mean age, 12.4 years; age range, 3 to 19 years) were identified. Night pain (90%) and symptom relief with nonsteroidal anti-inflammatory drugs (NSAIDs) (88%) were common clinical findings. Sclerosis/cortical thickening was visible in 58% of radiographs, although a radiolucent nidus was visible in only 42%. Diagnostic imaging findings included perilesional edema and a radiolucent nidus on 100% of available magnetic resonance imaging (MRI) and computed tomography (CT) scans, respectively. Initial alternative diagnoses were given in 23 cases (46%), the most common of which was femoroacetabular impingement (FAI). Delay in diagnosis of >6 months occurred in 43% of patients. Three patients underwent operative procedures for other hip diagnoses, but all had persistent postoperative pain until the OO was treated. Of the 41 patients (82%) who ultimately underwent radiofrequency ablation (RFA), 38 (93%) achieved complete post-RFA symptom resolution.

Conclusions:

Initial misdiagnosis, the most common of which was FAI, and delayed correct diagnosis are common in pediatric OO about the hip. Presenting complaints were variable and nonspecific MRI findings were frequent. Night pain and relief with NSAIDs were present in the vast majority of cases. CT scans provided definitive diagnosis in all patients who received them. As increasing numbers of young, active patients are being evaluated for various causes of hip pain, such as FAI, OO should not be overlooked in the differential diagnosis.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Perbuatan Melanggar Hukum Sebagai Unsur Utang Dalam Undang-Undang Nomor 37 Tahun 2004
Authors: Yudho Wibisono Adhityo
Published: April 2019

Kepailitan merupakan suatu lembaga bagi para kreditor dalam menagih pengembalian utang terhadap debitor. Hal tersebut biasanya dilakukan apabila pihak debitor dalam hal ini telah dalam keadaan pailit, yaitu suatu keadaan dimana debitor tidak lagi mampu untuk melakukan pembayaran-pembayaran terhadap utang-utang dari para kreditornya. Namun tujuan utama kepailitan adalah untuk melakukan pembagian antara para kreditor atas kekayaan yang dimiliki debitor oleh kurator. Dalam kepailitan terdapat beberapa prinsip penting, salah satunya yaitu adanya utang. Utang merupakan salah satu syarat utama diajukannya permohonan kepailitan, karena tanpa adanya utang tidaklah mungkin perkara kepailitan dapat diperiksa. Kemudian utang tersebut harus sudah jatuh tempo dan dapat ditagih. Pengajuan permohonan kepailitan pada umumnya didasarkan adanya perjanjian utang piutang antara pihak debitor dengan pihak kreditor. Dengan mendasarkan dari adanya perjanjian utang piutang tersebut pihak kreditor mengajukan permohonan kepailitan ke pengadilan. Sebagaimana diketahui terjadinya hubungan antara kreditor dan debitor atau adanya perikatan menurut Burgerlijk Wetboek ada dua, yaitu perikatan yang timbul dari adanya perjanjian dan perikatan yang timbul karena undang-undang. Kemudian bagaimana jika utang tersebut timbul sebagai akibat dari adanya perbuatan melanggar hukum, karena berbeda dengan utang yang timbul dari perjanjian utang piutang yang mengatur dengan jelas hubungan hukum antara kreditor dan debitor.Bankruptcyis an institution for creditors in collecting debt repayments against debtors. That’s usually done by creditors if the debtor in this case has been in a state of bankruptcy, that is a state in which the debtor is no longer able to make payments to the debts of its creditors. But the main purpose of bankruptcy is to make a division between the creditors of the assets owned by the debtor by the curator. In bankruptcy there are several important principles, one of which is the existence of debt. Debt is one of the main requirements for filing a petition for bankruptcy, because without debt it is not possible for bankruptcy cases to be examined. Then the debt should be due and billable. The filing of a bankruptcy application is generally based on a debt agreement between the debtor and the creditor. Based on the existence of the debt agreement, the creditor applying for bankruptcy to the court. As the relationship between creditors and debtor is known or there is an agreement according to Burgerlijk Wetboek there are two, namely the engagement that arises from the existence of agreement and engagement arising from the law. Then what if the debt arises as a result of the unlawful act, as it is different from the debt arising from the debt agreement of the receivables that clearly regulate the legal relationship between creditors and debtors.
Erratum to: Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy
Authors: Tsakou Eugenia , Agathagelidis Andreas , Boudjoghra Myriam , Raff Thorsten , Dagklis Antonis , Chatzouli Maria , Smilevska Tatjana , Bourikas George , Merle-Beral Helene , Manioudaki-Kavallieratou Eleni , Anagnostopoulos Achilles , Brüggemann Monika , Davi Frederic , Stamatopoulos Kostas , Belessi Chrysoula
Published: April 2019

Eugenia Tsakou, Andreas Agathagelidis, Myriam Boudjoghra, Thorsten Raff, Antonis Dagklis, Maria Chatzouli, Tatjana Smilevska, George Bourikas, Helene Merle-Beral, Eleni Manioudaki-Kavallieratou, Achilles Anagnostopoulos, Monika Bru.ggemann, Frederic Davi, Kostas Stamatopoulos, and Chrysoula Belessi. (2012) Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy. Mol. Med. 2012 Feb 10;18:138–45.
Comparative efficacy of different laryngoscopes in obese patients: a systematic review and network meta-analysis
Authors: Liu Miao , Zhang Zhaodi , Wang Guiyue , Li Yuhang , Yu Kaijiang , wang changsong
Published: April 2019

Background: Due to changes in the anatomical structure of oral pharynx, increased oxygen consumption and other pathophysiological changes, the airway management of obese patients is complex. Intubation is a critical step, and it is important to choose the optimal laryngoscope. Moreover, the best type of laryngoscopes to use for this population is unclear. The aim of this study is to determine the optimal laryngoscopes for endotracheal intubation in obese patients. Methods: We searched the Cochrane, Medline, EMBASE, EBSCOhost and Web of Science databases for randomized controlled trials comparing video laryngoscopes (VLs) with direct laryngoscopes (DLs) or different brands of VLs in adults with obesity for inclusion in this study. Results: A total of 13 trials with 1264 patients were identified. VLs were associated with an increase in the first-attempt success rate (relative risk (RR) 1.11, 95% confidence interval (CI) 1.06-1.16), shorter intubation time (MD -13.19, 95% CI -25.57 to -0.81) and an improved glottic view (RR 1.24, 95% CI 1.17-1.30). No difference was observed in the incidence of any complications. In the network meta-analysis, all three types of VLs (Macintosh blade VLs, angulated blade VLs and side-channel blade VLs) were associated with an improved glottic view (RR 1.4, 95% CI 1.2-1.7; RR 1.3, 95% CI 1.2-1.5; and RR 1.2, 95% CI 1.1-1.3, respectively). Conclusions: Compared with DLs, VLs generally increased the success rate on the first-attempt, reduced the intubation time and provided a superior glottic view without increasing complications. All three types of video devices improved visualization of the glottis. Trial registration: This study was registered with the International Prospective Register of Systematic Reviews (PROSPERO 2017: CRD42017079927. http://www.crd.york.ac.uk/PROSPERO).
Application of preemptive parasternal intercostal nerve block in patients undergoing off pump coronary artery bypass grafting:A Double-Blind,Randomised, Controlled Trial
Authors: zou mengmeng , ruan wei , xu junmei
Published: April 2019

Background: Parasternal intercostal nerve block as superficial block has been increasingly used for postoperative analgesia via performed before sternal suture placement, and has shown that this technique can provide effective postoperative analgesia and facilitate rapid-recovery. However, the impact of preemptive parasternal intercostal nerve block has not been researched for cardiac surgery patients.
Methods: Sixty-four patients underwent OPCABG were randomly divided into parasternal intercostal nerve block with ropivacaine ( n = 32) group and parasternal intercostal nerve block with saline ( n = 32) group. Before anaesthesia induction, 20ml of 0.35% Ropivacaine along with 1 mg dexamethasone or saline on each side, total dosage 40 ml, via parasternal intercostal injection. 5ml of 0.35% ropivacaine along with 0.5 mg dexamethasone or saline on each leg, total dosage 10 ml, via peripheral saphenous nerve block.
Results: The consumptions of intraoperative sufentanil and vasopressor were significantly lower in ropivacaine group(P＜0.05). Analgesia was adequate in the ropivacaine group up to 20 h. VAS score in the ropivacaine group significantly was lower compared with the saline group up to 12 h postoperatively(P＜0.05). The time of first rescue analgesic, anaesthesia recovery and extubation were significantly less in patients of the ropivacaine group(P＜0.05). The majority of the ropivacaine group patients did not need rescue dezocine, while the most of the saline group needed dezocine (P <0.05). The hemodynamic variables were stable in all patients. Few cases reported trivial adverse effects.
Conclusions: Preemptive parasternal intercostal nerve block provide adequate analgesia for the first 20 h after surgery and reduce intraoperative sufentanil, intraoperative norepinephrine and postoperative dezocine consumption as well as the time of extubation.
Trial registration: The study was registered at chictr.org.cn (identifier: ChiCTR1800017210，Registered 18 July 2018).
Characterizing the Phytotoxic Effects of Hydrogen Peroxide on Common Microgreen Species and Lettuce Cultivars
Authors: Eicher-Sodo Mitchell , Gordon Robert , Zheng Youbin
Published: April 2019

Hydrogen peroxide (H2O2) is an oxidizing agent used to disinfect recirculated irrigation water during the production of organic crops under controlled environmental systems (e.g., greenhouses). To characterize the phytotoxic effects and define a concentration threshold for H2O2, three microgreen species [arugula (Brassica eruca ssp. sativa), radish (Raphanus sativus), and sunflower (Helianthus annuus ‘Black Oil’)], and three lettuce (Lactuca sativa) cultivars, Othilie, Xandra, and Rouxai, were foliar sprayed once daily with water containing 0, 25, 50, 75, 100, 125, 150, or 200 mg·L−1 of H2O2 from seed to harvest under greenhouse conditions. Leaf damage was assessed at harvest using two distinct methods: 1) the percentage of damaged leaves per tray and 2) a damage index (DI). Applied H2O2 concentrations, starting from 25 mg·L−1, increased the percentage of damaged leaves in every species except ‘Black Oil’ sunflower, which remained unaffected by any applied concentration. Symptoms of leaf damage manifested in similar patterns on the surface of microgreen cotyledons and lettuce leaves, while mean DI values and extent of damage were unique to each crop. Fresh weight, dry weight, and leaf area of all crops were not significantly affected by daily H2O2 spray. Identifying how foliar H2O2 damage manifests throughout the crop, as well at individual cotyledon or leaf surfaces, is necessary to establish an upper concentration threshold for H2O2 use. On the basis of the aforementioned metrics, maximum recommended concentrations were 150 mg·L−1 (radish), 100 mg·L−1 (arugula) for microgreens and 125 mg·L−1 (‘Othilie’), 75 mg·L−1 (‘Rouxai’), and 125 mg·L−1 (‘Xandra’) lettuce.
STUDY OF GROUND PORK THAWING DYNAMICS USING MAGNETIC RESONANCE IMAGING
Authors: Stefanovskiy Vladimir M. , Morozov Evgeny V. , Bоuznik Vyacheslav M.
Published: April 2019

Visualization of changes in shape and size of the frozen residue during the thawing of ground pork is implemented using magnetic resonance imaging. A technique has been developed to study the displacement of thawing front line without damage to integrity of the object being thawed. It has been established that the melting of bound water crystals outran the melting of free water crystals in meat. A mathematical model that adequately describes the experimental data obtained in the analysis of tomograms is proposed. Tomograms are an important information source for studying the patterns of heat and mass transfer during the thawing of frozen foods.
LOW-TEMPERATURE ATMOSPHERIC-PRESSURE PLASMA IN MICROBIAL DECONTAMINATION AND MEAT TECHNOLOGY. A REVIEW
Authors: Gorbunova Natalia A.
Published: April 2019

The development of plasma technology is associated with the unique features of non-equilibrium low-temperature plasma: high electron energy and high concentration of chemically active excited and charged particles at low gas temperature, which allows to process thermolabile materials and biological objects in gentle conditions when high temperatures are not required. The biological effects of low-temperature plasma exposure are considered. It was established that during plasma treatment, a combined effect on cells and tissues of living systems from UV radiation, ions and chemically active particles occurs. Depending on the plasma type, the significance of each of the listed mechanisms for increasing the effectiveness of plasma treatment may vary. However, all these mechanisms interact with each other and have a synergistic effect. It was shown that the conducted studies confirm the ability of low-temperature plasma to inactivate pathogenic microorganisms upon contact with biological objects and foods. The results of the studies are presented, the purpose of which was to study the effect of plasma treatment on nitrite concentration in the water treated by this method and to assess the possibility of its use as a source of nitrite when curing meat products.
Últimos avances en la fabricación aditiva con materiales metálicos
Authors: Balbás Calvo Alexandra , Espinosa María del Mar , Domínguez Somonte Manuel
Published: April 2019

La aparición de la fabricación aditiva ha sido y es una de las grandes revoluciones industriales de las últimas décadas. Las diversas tecnologías de fabricación aditiva permiten la creación de piezas con formas muy complejas, muy difíciles de fabricar antaño, en las que además el desperdicio de material es prácticamente inexistente. La fabricación aditiva no solo sirve para la creación de maquetas, si no que se pueden crear piezas perfectamente funcionales, para ello, se suelen emplear materiales metálicos. Este artículo explora la evolución de las diferentes tecnologías de fabricación aditiva con materiales metálicos. Está dividido en cuatro secciones principales en las que se define la fabricación aditiva, se exponen los hitos más importantes de su reciente historia, se definen las tecnologías y materiales más característicos y se comentan los retos y las perspectivas de futuro de la misma.
La relación artística entre imagen y realidad en el cine colombiano
Authors: Ruiz Pulgarin Yulieth Estefanía
Published: April 2019

Desde una perspectiva filosófica, el presente trabajo tiene como propósito hacer una reflexión y análisis acerca de la relación artística entre la imagen y la realidad en el cine colombiano. Para tal objetivo, se empezará hablando de lo que da un valor artístico a la imagen cinematográfica en general, lo cual dará un marco conceptual para reflexionar acerca de la relación entre la imagen y lo real en el cine colombiano y, así, en esa misma clave de lectura, hacer un análisis de algunas películas.
Tecnologías inmersivas como estrategia de comunicación
Authors: Escobar Alvarez Kelly , Alvarez Zapata Daniel
Published: April 2019

En este artículo se desarrolla el concepto de eficacia de estrategias de comunicación mediadas por la implementación de tecnologías inmersivas en campañas educativas. Al entrar en una era de convergencia mediática nacen medios de los cuales se puede valer la publicidad para llegar a los nuevos consumidores que, con esta ola tecnológica, van surgiendo. Partiendo del análisis del caso particular de la estrategia implementada por la A.I.G en Panamá, que tuvo como objetivo lograr una migración exitosa a su nuevo Sistema Penal Acusatorio mediante una plataforma de aprendizaje digital, presentaremos los resultados de la investigación y cómo el uso de tecnología inmersiva hace más eficaz y versátil la transmisión de esta información al público.
Cuidadores, función inhibidora o autodeterminada de la sexualidad en la diversidad funcional
Authors: Castaño Molina Laura Alejandra , Godoy González Laura Daniela , Osorio Rivera Carolina , Taborda Marín Andrés Felipe , Villegas Castaño Jhenyfer , Mejía Zapata Sandra Isabel
Published: April 2019

El presente artículo pretende abordar las implicaciones que tienen las familias y cuidadores en el proceso de crianza de las personas en condición de diversidad funcional y cómo estos potencian el desarrollo integral de esta población. Para ello se aborda el modelo de la diversidad funcional desde cuatro categorías emergentes en la sistematización de la información, las cuales posibilitan una amplia mirada sobre el tema, haciendo énfasis en los tipos de crianza y cómo estos promueven o inhiben la capacidad de autodeterminación de este colectivo. Lo anterior se logra a partir de entrevistas a profundidad, dando lugar a la comprensión de las realidades significativas, e interpretaciones a la luz de la teoría. En cuanto al hallazgo que arrojo la investigación, se resalta que el apoyo de las familias y los cuidadores es determinante en tanto posibilitan el desarrollo o la inhibición de la autonomía.
Bases para comprender la diversidad de género y la diversidad sexual
Authors: Garibello Liberato Brayan Steven
Published: April 2019

El género no se limita únicamente por la genitalidad del individuo, hay una gran diversidad de géneros que se salen de los dos polos opuestos categorizados como “hombre” y “mujer” (géneros binarios), adjudicándole a cada uno de estos géneros patrones comportamentales y personalidades específicas y limitantes. Se conocen las diferentes características que componen a un individuo en su aspecto sexual e identitario con el género, como la expresión y la orientación sexual, pero más allá de esto hay un sinnúmero de características que se salen de las reglas y que no por eso los diversos tipos de géneros que no encajan en las imposiciones culturales deben ser invisibilizados o estigmatizados.
Chibcariwak
Authors: Herrera Uribe Yulieth Milena
Published: April 2019

El primero es una narración perteneciente a los avances del proyecto de investigación Narración y mediación digital que actualmente adelanta el semillero con la aprobación de la vicerrectoría de investigaciones. El segundo es un poema sobre los indígenas migrantes en la ciudad. Esta propuesta surge del trabajo de campo de la investigación para trabajo de grado de una de las integrantes del semillero.
El pescador
Authors: Gomez Oviedo Elva Emilia
Published: April 2019

La narración El Pescador es uno de los avances del proyecto que lleva como título “El comunicador social en formación como mediador para integrar narraciones en formatos digitales”, que actualmente ejecuta el semillero de investigación Mediáticos de la Facultad de Comunicación, Publicidad y Diseño de la Universidad Católica Luis Amigó. Este proyecto pretende explorar las bases narrativas y las plataformas tecnológicas que pueden ser empleadas por el comunicador social cuando se propone mediar en el paso de los formatos análogos a los digitales.
The bisoprolol efficiency predictors in patients with stable angina after myocardial infarction
Authors: Zamakhina O. V. , Bunova S. S. , Usacheva E. V. , Kulikova O. M. , Pomorgailo E. G. , Nikolayev N. A.
Published: April 2019

Objective: to identify the of bisoprolol effectiveness predictors in patients with stable angina after myocardial infarction.

Materials and methods: 107 patients with stable angina who underwent myocardial infarction aged 35–65 years (mean age 54,7 ± 6,2 years) were examined in an open, comparative, register study, of which groups were generated: with the achieved and unreached target heart rate (60 or less in 1 minute). Additionally, the respondents were stratified into subsamples by the presence of ADRB1 gene Arg389Gly polymorphism. All patients underwent a 5-minute study of heart rate variability (HRV) in the background sample and in active orthostasis and the determination of the ADRB1 gene polymorphism (Arg389Gly, rs1801253) by PCR. All patients received bisoprolol in the selected optimal maximum-tolerated dose.

The main results: respondents who did not reach the target heart rate significantly more often complained about heartbeat and heart rhythm interruptions (p = 0,003), increased incidence of cardiac pain episodes (p = 0,02), noted a high demand for nitrates (p = 0,03) and significantly more often sought medical help. In respondents with the achieved target heart rate, sympathetic influences were less expressed in the background HRV sample with significantly higher parasympathetic influences expression by contrast. The number of sympathicotonics in terms of HRV at rest was significantly higher among respondents with unreached heart rate. When comparing the frequencies of alleles in respondents with the achieved target heart rate, a significant (p = 0.0001) prevalence of carriers of the Gly allele of the ADRB1 gene Arg389Gly polymorphism was revealed. The heart rate in carriers of the Gly allele in homo-or heterozygous form was significantly lower than in carriers of the homozygous genotype Arg389Arg.

Conclusion: The predictors of the bisoprolol effectiveness in achieving the target heart rate in patients with stable angina after MI are: a stress index less than 104.5 cu. in the background sample of a 5-minute HRV, the presence of the polymorphic Gly allele of the ADRB1 gene Arg389Gly polymorphism, the age of less than 46 years, and the total spectrum power in the background HRV sample of more than 1309 ms.
Reproductive outcomes following surgical removal of uterine fibroids
Authors: Mitichkin A. E. , Dobrokhotova Yu. E. , Ivannikov N. Yu. , Dimitrova V. I. , Slyusareva O. A. , Khlynova S. A. , Lyubeshkina V. A. , Mustafaeva T. G.
Published: April 2019

The cohort prospective comparative study investigated the efficacy of mifepristone use in patients after surgical treatment of uterine myoma. It was shown that the use of mifepristone at a dose of 50 mg/day in a continuous mode for 3 months after surgical treatment for proliferating uterine myoma led to the absence of recurrences of the disease for 2 years after the drug withdrawal. The use of mifepristone after embolization of uterine arteries allowed to significantly reduce the size of the node by 25% during 12 months and by 50% (p<0.05) after 24 months. Complex treatment of uterine myoma, including myomectomy and drug therapy with mifepristone, allowed to realize reproductive function in 46% of patients, and delivery through the natural birth canal occurred in 24% of patients.
Non-surgical treatment of uterine fibroids. Efficacy of the selective progesterone receptor modulator
Authors: Dovletkhanova E. R. , Mezhevitinova E. A. , Prilepskaya V. N.
Published: April 2019

The leading role of ovarian steroid hormones in the pathogenesis of uterine fibroids is confirmed by epidemiological, clinical and experimental studies. The new approaches to the treatment of this disease may be developed on the basis of the biological and genetic mechanisms underlying the occurrence and development of leiomyomas. The use of ulipristal acetate in patients with uterine leiomyoma may be a promising method for preparing them to the surgical procedures, but also for avoiding surgical treatment and related hypoestrogenic conditions, which results in the improvement of the women’s quality of life.
Overview of the therapeutic possibilities of combined oral contraceptive containing estradiol valerate and dienogest
Authors: Lisitsyna O. I. , Khilkevich E. G.
Published: April 2019

Taking into account that the frequency of abortions in Russia today remains quite high, the strategy of fertility regulation through the provision of contraceptive advice to women of various ages comes to the fore. It has been proven that combined oral contraceptives are the most effective method of preventing unwanted pregnancies. An innovative combination of oral contraceptives containing estradiol valerate (EV) and dienogest (DNG) dynamically provides effective inhibition of ovulation and sufficient cycle control. DNG/EV has high efficacy, acceptability and tolerability and can be successfully used in sexually active women in need of contraception, regardless of their age. Like any modern contraceptive, this drug possesses a whole arsenal of pronounced therapeutic possibilities, which can be used in real clinical practice. In addition, the combination of EV and DNG is highly effective in the therapy of menorrhagia. The percentage of patients who had successful treatment and resulted in a decrease in menstrual blood loss was high. The effectiveness of the drug is confirmed by the bleeding of withdrawal at the end of the first treatment cycle and continues to increase gradually with further administration.
Effective treatment of skin and metabolic manifestations of hyperandrogenism: a comprehensive improvement of quality of life
Authors: Balan V. E. , Zaydieva Ya. Z. , Tikhomirova E. V.
Published: April 2019

Clinical manifestations of hyperandrogenism can be an important diagnostic symptom of polycystic ovary syndrome, and in most cases allow establishing this diagnosis in a timely manner. The article discusses the problem of acne not only in adolescence, but also in adult women, and the problem of hirsutism in detail. It shows the role of combined oral contraceptives (COCs) as an effective therapy for acne and hirsutism in women, as well as the first-line therapy for polycystic ovary syndrome, according to the international and national clinical guidelines. The data summarize the effectiveness of the use of COCs containing drospirenone as a gestagenic component and levomefolate calcium in order to compensate for folate deficiency and, accordingly, reduce the level of homocysteine, which is often elevated in women with hyperandrogenism.
Prevention of premature birth in pregnant women with vaginal candidiasis
Authors: Kokoeva D. N. , Medzhidova M. K. , Lomova N. A. , Kan N. E. , Tyutyunnik V. L.
Published: April 2019

Candida vulvovaginitis is an infectious lesion of the vulvar and vaginal mucosa caused by Candida yeast fungi. Vaginal candidiasis during pregnancy is associated with spontaneous miscarriages, premature rupture of the fetal membranes, premature birth, and low birth weight babies. Considering the potential risk of premature delivery at fungal invasion at the level of the lower reproductive tract of a pregnant woman, the search for a complex of preventive measures and timely treatment of сandida vulvovaginitis during gestation is of particular interest. The article presents the results of the use of the drug Zalain in 36 pregnant women, with a gestation period of 28 weeks or more with acute candidal vulvaginitis. In the course of the work, the results of local therapy with Zalain were evaluated and its clinical efficacy in the prevention of preterm labor was confirmed. The results of treatment contribute to a significant reduction in the frequency of initiation of preterm labor, as well as a persistent effect for 2-4 weeks after completion of the course in the postpartum period and the absence of early and distant manifestations of candidiasis in newborns.
Application of microablative fractional CO2-laser photothermolysis for correction of age-associated processes of vulvovaginal area
Authors: Apolihina I. A. , Nazimova E. M.
Published: April 2019

During the course of their lives, almost all women face pathological changes in the vulvovaginal area caused by various causes: dysplasia of connective tissue, excessive physical activity, childbirth, reduction of sex hormones, etc. Vulvovaginal symptoms have no significant impact on life expectancy and have a significant impact on the quality of life. In this regard, the modern possibilities of correction of these conditions, especially the minimally invasive ones, become especially important. The article discusses the methods of treatment and prophylaxis of age-associated pathological changes in the vulvovaginal area using a CO2-laser. Mechanisms of laser radiation influence on tissues are considered when using different modes. The advantages of microablative CO2-fraction laser photothermolysis in vaginal and vulva tissue rejuvenation programs are shown. The analysis of clinical studies on the use of lasers in the treatment of vulvovaginal diseases has been carried out, and tasks have been set for the development and implementation of highly effective and safe technologies in the practice of gynaecologists that affect the mucous membranes of the vagina and vulva, as well as a reliable assessment of their effectiveness.
Numerical implementation of finite-element method of control volume using irregular mesh
Authors: Gafarova Yu.A.
Published: April 2019

To solve problems with complex geometry it is considered the possibility of application of irregular mesh and the use of various numerical methods using them. Discrete analogues of the Beltrami-Mitchell equations are obtained by the control volume method using the rectangular grid and the finite element method of control volume using the Delaunay triangulation. The efficiency of using the Delaunay triangulation, Voronoi diagrams and the finite element method of control volume in a test case is demonstrated.
Numerical simulation of the spherically symmetric tumor growth in the lymph node
Authors: Kireev V.N. , Solnyshkina O.A.
Published: April 2019

Within the framework of the multiphase systems mechanics we consider the mathematical model of the initial stage of the tumor growth in a lymph node consisting of two kinds of cells. Adhesive intercellular interaction and distribution of nutrients (oxygen) are taken into account. For a spherically symmetric case, the distribution of tumor growth parameters was numerically obtained and some features of its development at the initial stage were defined.
Current Understanding of Group A Streptococcal Biofilms
Authors: Vyas Heema K.N. , Proctor Emma-Jayne , McArthur Jason , Gorman Jody , Sanderson-Smith Martina
Published: April 2019

Background:

It has been proposed that GAS may form biofilms. Biofilms are microbial communities that aggregate on a surface, and exist within a self-produced matrix of extracellular polymeric substances. Biofilms offer bacteria an increased survival advantage, in which bacteria persist, and resist host immunity and antimicrobial treatment. The biofilm phenotype has long been recognized as a virulence mechanism for many Gram-positive and Gram-negative bacteria, however very little is known about the role of biofilms in GAS pathogenesis.

Objective:

This review provides an overview of the current knowledge of biofilms in GAS pathogenesis. This review assesses the evidence of GAS biofilm formation, the role of GAS virulence factors in GAS biofilm formation, modelling GAS biofilms, and discusses the polymicrobial nature of biofilms in the oropharynx in relation to GAS.

Conclusion:

Further study is needed to improve the current understanding of GAS as both a monospecies biofilm, and as a member of a polymicrobial biofilm. Improved modelling of GAS biofilm formation in settings closely mimicking in vivo conditions will ensure that biofilms generated in the lab closely reflect those occurring during clinical infection.
Influence of New Synthetic Xanthones on the Proliferation and Migration Potential of Cancer Cell Lines In Vitro
Authors: Szkaradek Natalia , Sypniewski Daniel , Żelaszczyk Dorota , Gałka Sabina , Borzdziłowska Paulina , Marona Henryk , Bednarek Ilona
Published: April 2019

Background:

Natural plant metabolites and their semisynthetic derivatives have been used for years in
cancer therapy. Xanthones are oxygenated heterocyclic compounds produced as secondary metabolites by higher
plants, fungi or lichens. Xanthone core may serve as a template in the synthesis of many derivatives that have broad
biological activities.

Objective:

This study synthesized a series of 17 new xanthones, and their anticancer potential was also evaluated.

Methods:

The anticancer potential was evaluated in vitro using a highly invasive T24 cancer cell line. Direct cytotoxic
effects of the xanthones were established by IC50 estimation based on XTT assay.

Results:

5 compounds of the total 17 showed significant cytotoxicity toward the studied cancer cultures and were
submitted to further detailed analysis, including studies examining their influence on gelatinase A and B expression,
as well as on the cancer cells migration and adhesion to an extracellular matrix. These analyses were carried out on
five human tumor cell lines: A2780 (ovarian cancer), A549 (lung cancer), HeLa (cervical cancer), Hep G2 (liver
cancer), and T24 (urinary bladder cancer). All the compounds, especially 4, showed promising anticancer activity:
they exhibited significant cytotoxicity towards all the evaluated cell lines, including MCF-7 breast cancer, and
hindered migration-motility activity of cancer cells demonstrating more potent activity than α-mangostin which
served as a reference xanthone.

Conclusion:

These results suggest that our xanthone derivatives may be further analyzed in order to include them in
cancer treatment protocols.
Withdrawn: Effect of Ursodeoxycholic Acid, Lawsonia Inermis and Achil-lea Millefolium Extracts on Hydatid Cyst Protoscolices
Authors: Sanei Behnam , Tavakoli Pouria , Hadipour Mahboubeh , Darani Hossein Yousofi
Published: April 2019

The article has been withdrawn on the request of the authors and the editor of the journal Infectious Disorders - Drug Targets.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneous-ly submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers, if and when the article is accepted for publication.
Adenosine Receptors and Drug Discovery in the Cardiovascular System
Authors: Khayat Maan T. , Hanif Ahmad , Geldenhuys Werner J. , Nayeem Mohammed A.
Published: April 2019

The signaling nucleoside adenosine is produced intra- and extracellularly under physiologic and, more importantly, under pathologic conditions. Adenosine modulates cellular functions involved in injury, metabolic derangement, energy perturbations, and inflammation. The biologic effects of adenosine are mediated by four adenosine receptor (AR) subtypes of the G-protein coupled receptors (GPCRs) family: A1AR, A2AAR, A2BAR and A3AR. In the cardiovascular (CV) system, adenosine and its receptors are intricately involved in the regulation of myocardial contraction, heart rate, sympathetic control, conductivity, vascular tone, cardiac and vascular growth, inflammation, injury and apoptosis. As such, the modulation of the adenosinergic system has therapeutic potential for cardiovascular diseases (CVDs) such as metabolic disorders, atherosclerosis, hypertrophy, ischemic heart diseases, and heart failure. Nevertheless, despite the many years of investigation and experimentation only a few drugs targeting the adenosinergic system were developed and actually have reached clinical application. This chapter outlines the unique role adenosine plays in the CV system in physiology, pathology, and potentially therapeutic pharmacology. It also presents an updated review of the different adenosine receptors ligands, and their clinical potential in different CVDs.
Platelet Reactivity in Patients with Coronary Stenting Treated with Dual Antiplatelet Therapy and after Withdrawal of Clopidogrel: Impact of Bioactive Titanium Stent versus Everolimus-coated Stent
Authors: Hernandiz Amparo , Díez Jose Luis , Moscardo Antonio , Latorre Ana , Domenech Maria Dolores , Santos Maria Teresa , Valles Juana
Published: April 2019

Objective:To study platelet reactivity at different times while on dual antiplatelet
therapy (DAPT) with aspirin (ASA) and clopidogrel in patients treated with bioactive
stents (TITAN2®) or everolimus-coated stents (XIENCE V®) and one month afterclopidogrel cessation.

Background: Coronary intervention damages the endothelium and causes platelet response leading to thrombotic occlusion, which is prevented with DAPT.

Methods:We studied 20 patients with bioactive stent and stable ischemia (BAS-SI
group); 31 patients with bioactive stent and acute coronary syndrome (BAS-ACS
group) and 31 patients with stable ischemia and everolimus-coated stent (EVE group).
DAPT was administered (ASA 100 mg/day and clopidogrel 75 mg/day) for one year in
BAS-ACS and EVE groups and for 1 month in BAS-SI group. Platelet aggregation
induced by different agonists and platelet recruitment were analyzed at different times
of DAPT and 1 month after clopidogrel cessation.

Results: After one month of DAPT, platelet aggregation showed no difference between
groups; at 12 months of DAPT, the response to collagen and ADP increased in EVE group. Platelet recruitment at 1 month was higher in the BAS-ACS than the other
groups; after 12 months, recruitment increased in the EVE group with respect to BASACS.
Platelet aggregation and recruitment in diabetics were significantly higher in all
situations than in non-diabetic patients. Clopidogrel withdrawal increased ADPinduced
aggregation and collagen-induced aggregation and recruitment.

Conclusion: Platelet reactivity in patients with DAPT varies with time, depending on
the subset of patients, the type of the stent implanted and the time after implantation.