bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Modelling of Tensile Mechanical Behavior of a Bio-Composite Based on Polybutylene-Succinate and Brewer Spent Grains
Authors: Visco Annamaria , Scolaro Cristina , Ruta Aldo Jesus , Oliveri Francesco
Published: October 2024

A model based on the fitting of stress-strain data by tensile tests of biocomposites made of a bioplastic (polybutylene succinate, PBS) and spent brewer's grain filler (BSGF) is developed. The model is suitable to describe the elastic-plastic behavior of these materials in terms of two mechanical parameters (tensile stress and tensile stiffness or Young's modulus) depending on the filler concentration. The mechanical characteristics, derived from the fitting parameters, show a good agreement with the experimental data. The mathematical model used here could be an important aid for the experimentation and the manufacturing process as it allows to predict the mechanical tensile parameters of a mixture with different filler concentrations, avoiding the long and complex preparation cycle of bio-composites, as well as the specific mechanical tests. The physical properties required by the objects created with the PBS-BSGF bio-composite by the partners/stakeholders of the research project co-financing this research, can be quite different. Therefore, a mathematical model that predicts some of the mechanical properties in terms of the mixture composition may be useful to speed up the selection of the required amount of BSGF in the mixture.
Investigation of Structural Changes in TiSiCN Powders During Mechanical Activation
Authors: Baimoldanova Lazat , Rakhadilov Bauyrzhan , Kengesbekov Aidar , Kuanyshbai Rashid
Published: October 2024

In modern materials science and surface engineering, Reactive Plasma Spraying (RPS) occupies a key po-sition due to its ability to create high quality coatings with unique properties. However, the efficiency of this process is highly dependent on the physicochemical characteristics of the starting powder materials. Mechanical activation, as a pretreatment, can have a significant effect on the structure and reactivity of powders, thereby modifying and improving the RPS process. The present study focuses on analysing the changes that occur to powder materials after mechanical activation and their subsequent effects on the quality and performance of coatings produced by the RPS process. The study of these changes is of key importance for optimising the spraying process as well as developing new materials with improved methods. This is important not only to improve the efficiency of reactive plasma spraying technologies, but also to expand their applications in various industrial and scientific fields. Improved materials can be a decisive factor in increasing the productivity and prevalence of products, as well as creating new opportunities for innovation and development in various industries.
Illuminating Malaria: Spectroscopy's Vital Role in Diagnosis and Research
Authors: Wood Bayden R. , Adegoke John A. , Chakkumpulakkal Puthan Veettil Thulya , Dodla Ankit , Dias Keith , Mehlawat Neha , Gassner Callum , Stock Victoria , Joshi Sarika , Giergiel Magdalena , Bedolla Diana E. , Heraud Philip
Published: October 2024

Spectroscopic techniques have emerged as crucial tools in the field of malaria research, offering immense potential for improved diagnosis and enhanced understanding of the disease. This re-view article pays tribute to the pioneering contributions of Professor Henry Mantsch in the realm of clinical biospectroscopy, by comprehensively exploring the diverse applications of spectro-scopic methods in malaria research. From the identification of reliable biomarkers to the devel-opment of innovative diagnostic approaches, spectroscopic techniques spanning the ultraviolet to far-infrared regions have played a pivotal role in advancing our knowledge of malaria. This re-view will highlight the multifaceted ways in which spectroscopy has contributed to the field, with a particular emphasis on its impact on diagnostic advancements and drug research. By leverag-ing the minimally invasive and highly accurate nature of spectroscopic techniques, researchers have made significant strides in improving the detection and monitoring of malaria parasites. These advancements hold the promise of enhancing patient outcomes and aiding in the global ef-forts towards the eradication of this devastating disease.
Robotic-Assisted Surgery in Urology: Adoption and Impact in Poland
Authors: Śliwczyński Andrzej , Szymański Michał , Wierzba Waldemar , Furlepa Kamila , Korcz Tomasz , Brzozowska Melania , Glinkowski Wojciech
Published: October 2024

Background/Objectives: The introduction of robotic surgery has revolutionized surgical procedures bringing significant improvements in procedures such as radical prostatectomy. In Poland, robotic technology was first used in public healthcare in 2010 for colorectal surgery in Wrocław. Public funding for robotic urologic surgery began in 2022. The aim of this study is to evaluate the impact of integrating a stable source of funding on the development and utilization of robotic surgery. Methods: Using data from the National Health Fund, a retrospective analysis of these procedures was conducted, focusing on radical prostatectomies from the beginning of the funding period to November 2023. Results: The study showed that in the first year of public funding (2022), 2,149 radical prostatectomies were performed using robotic systems, and this number almost doubled to 4,331 by October 2023. Patients aged 60 years and older accounted for more than 80% of those undergoing robotic surgery. The rise in the popularity of robotic surgery is attributed to its advantages, including high precision, reduced invasiveness in the surgical field, minimized bleeding and pain, and reduced postoperative wound size. The use of robotic surgery also brings environmental benefits. Conclusions: The growing number of robot-assisted surgeries in Poland reflects the increasing role of robotics in medicine. These advances meet the growing demand for healthcare services and demonstrate the precision and effectiveness of robotic technology, potentially improving healthcare access and outcomes. Further implementation and refinement of robotic solutions are necessary to meet the changing needs of medical specialties.
Use and Overuse Leading the Conservation Issues of the Endangered Flagship Species Artemisia granatensis
Authors: Lorite Juan
Published: October 2024

Here I examine the overexploitation of Artemisia granatensis, a narrow endemic medicinal plant species from Sierra Nevada, Spain, and the consequences for its conservation. With over 50,000 flowering plant species used for medicinal purposes worldwide, many species face sustainability issues due to overharvesting and habitat loss. Historical documentation of A. granatensis use dates back to the 13th century, highlighting its significance in traditional medicine. However, this species has suffered extensive overexploitation, particularly in the 19th and 20th centuries, leading to a significant decline in populations. Conservation concerns were first raised in 1909, and despite the species being legally protected since 1982, illegal collection and environmental pressures persist. Today, A. granatensis is critically endangered, with fewer than 2,000 individuals remaining in fragmented populations. The study synthesizes historical and recent literature to understand the long-standing pressures on this species and the limited conservation efforts made. Cultivation of A. granatensis is proposed as a crucial strategy to reduce pressure on wild populations and ensure the survival of this flagship important plant species.
The Level of Nutritional Awareness; Body Mass Index; Mental Health; Fitness Components among Undergraduate University Students
Authors: AlKilani Laila Fathi , Awad Salwa Saad , ALTamimi Jozaa Zaidan , Alharbi Fatimah Sayer
Published: October 2024

This study investigated the relationship between mental health, physical activity, and weight among Saudi female university students. A cross-sectional survey was conducted to assess participants' risky behaviors, psychological health, and health-related habits. Results revealed that a significant number of students had unhealthy eating habits, low levels of physical activity, and were overweight. While there was a slight trend towards lower physical activity and higher weight among individuals with higher depressive symptoms, these relationships were not statistically significant. The study concludes that factors beyond mental health, such as cultural norms and social support, likely play a more significant role in influencing physical activity levels and weight among Saudi university students. Further research is needed to identify these factors and develop targeted interventions to promote healthier lifestyles.
The Presence of Some Minor Aspergillus and Penicillium Mycotoxins: Mycophenolic Acid, Cyclopiazonic Acid, Penicillic Acid, Roquefortine C, and Gliotoxin in Main Cereals Cultivated in Albania
Authors: Topi Dritan , Damani Zamir , Babič Janja , Jakovac-Strajn Breda , Tavčar-Kalcher Gabrijela
Published: October 2024

(1) Background: Food and Feed Safety Legislation does not concern all the mycotoxins generated by Penicillium and Aspergillus spp. Certain mycotoxins, including cyclopiazonic acid (CPA), penicillic acid (PA), roquefortine C (ROQ C), mycophenolic acid (MPA), and gliotoxin regarded as having lower toxicity levels, hence not included in food and feed legislation; (2) Methods: Presence of these substances in maize and wheat grown in Albania across two consecutive harvesting seasons was investigated by liquid chromatography and mass spectrometry (LC-MS/MS); (3) Results: The findings indicated the presence of these mycotoxins in maize grain but not in wheat grain. In the 2014 season, they exhibited a higher contamination incidence than the 2015 season. The most commonly detected Mycotoxin was MPA, followed by CPA and ROC toxin, while Penicillium acid and gliotoxin were detected. The MPA revealed a concentration range of 72.92–3447.25 μg/kg, with a mean value of 1063.89 μg/kg. Mycophenolic acid was detected in the maize samples collected during the 2015 season. (4) Conclusions: These findings suggest that focusing the investigation only on 'controlled' mycotoxins will not produce a proper risk assessment and may not adequately address the possible harmful impacts of mycotoxins on human and animal health due to mycotoxins co-occurrence.
Loneliness among High School Students during the COVID-19 Pandemic and its Long-term Mental Health Impact
Authors: WONG Johsnton HC , Johnston HC WONG Lam T. Le Huong Phan Mai , Huong Phan Mai
Published: October 2024

Loneliness was one of the most prominent emotional experiences during social distancing due to the COVID-19 pandemic. This article aims to shed light on the experiences of loneliness and its relationship with mental health of adolescents in the Da Nang City during the COVID-19 pandemic. Data were collected online in early 2023 after 18 months Da Nang lifted its lockdown. The Strength and Difficulties Questionaire, the Multidimensional Scale of Perceived Social Support and the Negative Experience Scale were used to investigate loneliness among adolescents and effects of protective social factors. A total of 1,262 grade 6 to 12 students responded to the surveys. Results indicated that (1) loneliness was a more prominent emotion experienced by these adolescents during the COVID-19 lockdown; (2) factors contributing to loneliness were related to illness, social distancing, and a lack of care and attention from parents; (3) loneliness reported mostly was short in duration and mild at level, while there was a significant proportion of prolonged loneliness; and (4) Support from family and friends, however, could reduce the risk of mental health problems for the youngsters.
FAR-UV Technology and Germicidal Ultraviolet (GUV) Energy: A Policy and Research Review for Indoor Air Quality and Disease Transmission Control
Authors: Linder Alexander , Zhu Alexander , Bruns Richard , Olsiewski Paula , Gronvall Gigi
Published: October 2024

COVID-19 highlighted the challenges of public acceptance of public health measures, including mask-wearing and vaccination. which has spurred interest in engineered approaches to reduce infections. Germicidal Ultraviolet (GUV) Energy has been used for decades in hospital rooms to limit TB transmission, but it is expensive to install in the upper part of rooms where it may be used safely. In contrast, FAR-UV energy is a relatively new, flexible technology that can be set up in rooms for moderate costs, and studies thus far indicate it is efficacious and not damaging to eyes or skin. To examine the state of the field, experts in aerosol biology, infection control, and building engineering from academia, government, and industry were convened to inform policy recommendations for future investments, identify research required, and examine policy options for using these technologies. Despite its high efficacy for deactivating several types of microorganisms and pathogens of concern, before FAR-UV technologies may be widely deployed, additional studies are needed to understand potential adverse effects, as well as the best approaches to use, standardize, and regulate the technology. In some environments, the use of FAR-UV can generate ozone, which can react with volatile organic compounds that may be hazardous to human health, such as respiratory tract irritation. Even with these concerns, the demonstrated effectiveness in disease control of both FAR-UV and longer wavelengths of GUV deserve increased policy attention to reduce risks of indoor disease transmission. While potentially useful to counter disease in high-risk indoor environments, further standardization and regulatory measures, as well as research into the production of oxidative compounds is necessary before broad adoption of FAR-UV.
Rapid Immobilisation of Chemical Reactions in Alkali-Activated Materials Using Solely Microwave Irradiation
Authors: Tesovnik Anže , Horvat Barbara
Published: October 2024

Efflorescence is a major concern in alkali-activated materials (AAMs), affecting their potential practical applications and challenging the preservation of the material in a time-frozen state for post-characterisation purposes. Efflorescence is a time-dependent phenomenon that may stop with complete water removal. Therefore, this study mixed chemically and physically different secondary raw (slag, fly ash, glass wool, and rock wool) and nonwaste (metakaolin) materials with Na-silicate solution in ratios that facilitated efflorescence and mixtures that could prevent it. The material was cured at 40 °C for 6 days. On the 7th day, half of the intact samples were additionally treated with low-power microwaves (2.45 GHz at 100 W) until complete dehydration to rapidly and gently influence the chemical reaction. The impact of microwave-irradiation-induced dehydration on the specimens was thoroughly examined on day 7, both chemically and physically, and compared with that of a set of samples that were not subjected to dehydration. Chemical alterations were examined using Fourier transform infrared spectroscopy, which revealed the removal of water. Further, X-ray diffraction revealed no changes in crystallinity upon irradiation. The irradiation-increased porosity was evaluated through Mercury Intrusion Porosimetry, whereas the mechanical resilience of the materials was evaluated through compressive strength tests and synchronised with the porosity development. Pores in the irradiated samples that required higher temperatures or longer curing times (glass wool, fly ash, and metakaolin) were spherical; otherwise, dehydration resulted in elongated cracks. This result provided side knowledge on the determination of finalisation of the curing of AAM, which cannot be determined by any surface-penetrating test. Efflorescence formation was evaluated on 1-year-old dehydrated samples, maintained at room temperature, before and after exposure to a water droplet using a low-vacuum scanning electron microscope. This explained the reason why the surface of AAMs exposed to water became slippery and the effect of the water droplet on the surface. The microwave treatment method successfully accomplished the complete dehydration of AAMs within a few minutes, effectively inhibiting reactions in the AAMs, terminating further development of the aluminosilicate network, and partially removing unbonded alkali elements from the chemically unfinished AAM system. Therefore, microwave irradiation can be used to evaluate the chemical compositions of time-evolving materials during dehydration. If the dehydrated samples are stored in a waterless environment, post-characterisation of the AAMs is possible at any later time. The procedure of stopping the reactions offers significant advantages over conventional techniques which require physical processing, such as grinding or milling, the use of solvents, and more time.
The Proliferation of Artificial Intelligence in the Forklift Industry – an Analysis for the Case of Romania
Authors: Goga Alexandru-Silviu , Toth Zsolt , Meclea Mihai-Alin , Puiu Ionela-Roxana , Boșcoianu Mircea
Published: October 2024

This paper delves into the transformative impact of artificial intelligence (AI) in the forklift industry, particularly focusing on logistics and procurement within small and medium-sized enterprises (SMEs) in the field of industrial machinery. The study highlights the growing influence of AI in automating and improving the forklift industry. Using the environmental, social, and corporate governance (ESG) balanced scorecard (BSC), benchmarking, and activity-based management (ABM) models, the paper analyses the risks and the implications of AI integration in the industry in the actual turbulent context. The research highlights the significant shifts in logistics and procurement processes due to AI, projecting a future where forklift operations are deep automatized, leading to a possible loss of forklift operator jobs. A case study of the most relevant Romanian SME in the forklift industry is also presented, examining the company's financial strategies using McKinsey’s 7S framework. The paper concludes with a perspective that, in the future, machines will predominantly operate in roles currently held by humans, significantly altering the industry landscape.
Assessing the Effects of Unit-Based Pricing on Household Waste Reduction During COVID-19 in Japan
Authors: Karasawa Michiko , Taguchi Hiroyuki
Published: October 2024

Focusing on the COVID-19 period in Japan, this study identifies the effectiveness of a municipal unit-based pricing (UBP) system on household waste reduction through a panel data analysis targeting 770 cities for 2013–2022. It focuses on simple unit pricing (SUP) and two-tiered pricing (TTP) systems as the UBP components. As previous studies have not considered the COVID-19 period when assessing UBP, this study significantly contributes to the literature by providing new evidence. The main findings are as follows: First, SUP effectively reduced household waste during the COVID-19 period, although its effectiveness was slightly neutralized owing to the pandemic environment. Second, TTP efficiently restrained household waste during the COVID-19 period, when people became cautious about their excessive waste volumes beyond the TTP criteria. The study implicates the need to expand the municipal adoption of the UBP system for household waste reduction.
3 Dimensional DC Placement: Drone Placement for Optimal Coverage
Authors: Basu Aniket , Oroojeni Hooman , Samakovitis Georgios , Al-Rifaie Mohammad Majid
Published: October 2024

Using Drone Cells to optimize Radio Access Networks is an exemplary way to enhance the capabilities of terrestrial Radio Access Networks. Drones fitted with communication and relay modules can act as Drone Cells. The multi Drone Cell placement problem is solved using an adapted Dispersive Flies Optimization alongside with other meta-heuristic algorithms such as Particle Swarm Optimization and Differential Evolution. A home-brewed simulator has been used to test the effectiveness of the different implemented algorithms. Specific environment respective parameter tuning have been explored to better highlight possible advantages of one algorithm over other in any particular environment. Algorithmic diversity has been explored, leading to several modifications and improvements in the implemented models. The results show that using tuned parameters there is a performance uplift in coverage probability when compared to the default meta-heuristic parameters while still remaining within the constraints implied by the problem’s requirements and resource limitation. The paper concludes by offering a study between multiple meta-heuristic approaches and comparison between the methods, investigating the impact of parameter-tuning as well as analyzing the impact of intermittent restart for algorithms persistent diversity.
A Critical Review of Applied Behavior Analysis (ABA): Trends & Gaps
Authors: Gupta Mayank , Khurana Priyal , Gupta Nihit
Published: October 2024

Applied behavior analysis (ABA) was initially developed in the 1960s based on behaviorist theories, gained popularity as a teaching method for individuals with ASD. The practice employs theoretical behavior analytic principles to address social and life skills amongst a few. With the wide acceptance and prevalence of ABA, the need to provide based on specific challenges of individual can get fogged. The present paper is a critical review of the trajectory of ABA and how it became the gold standard treatment for autism. It also focuses on identifying gaps in the current literature to guide the path for upcoming professionals working in the field of behavioral inteventions for children with autism.
Malnutrition in Nepal: A Comprehensive Analysis of Micronutrient Deficiencies, Health Impacts, and Intervention Strategies"
Authors: Agrawal Roshan
Published: October 2024

Malnutrition, particularly micronutrient deficiencies, remains a significant public health challenge in Nepal, affecting vulnerable populations such as children under five, pregnant women, and lactating mothers. This thesis examines the complex landscape of malnutrition in Nepal, focusing on the causes, health impacts, and socio-economic consequences of nutrient deficiencies. The research highlights the severe effects of malnutrition, including stunting, anemia, and developmental delays, which contribute to broader social and economic disparities. A detailed analysis of the most affected populations and regions, based on national surveys and studies, underscores the critical need for targeted interventions. This study also evaluates existing nutrition programs in Nepal, assessing their effectiveness and identifying gaps in coverage, particularly in remote and rural areas. The findings emphasize the importance of a multi-sectoral approach that integrates nutrition-specific interventions with broader efforts to improve food security, healthcare access, and economic opportunities.
New Predictive Model for the Computation of Reinforced Concrete Column Shear Strength
Authors: Ioannou Anthos Ioannis , Galbraith David , Bakas Nikolaos , Markou George , Bellos John
Published: October 2024

The assessment methods for estimating the behavior of the complex mechanics of reinforced concrete (RC) structural elements were primarily based on experimental investigation, followed by collective evaluation of experimental databases from the available literature. There is still a lot of uncertainty in relation to the strength and deformability criteria that have been derived from tests due to the differences in the experimental test setups of the individual research studies that are being fed into the databases used to derive predictive models. This research work focuses on structural elements that exhibit pronounced strength degradation with plastic deformation and brittle failure characteristics. The study’s focus is on evaluating existing models that predict the shear strength of RC columns, which take into account important factors including the structural element’s ductility and axial load, as well as the contributions of specific resistance mechanisms like that of concrete, transverse, and longitudinal reinforcement. Significantly improved predictive models are proposed herein through the implementation of machine learning (ML) algorithms on refined datasets. Three ML models, LINREG, POLYREG-HYT, and XGBoost-HYT-CV, were used to develop different predictive models that were able to compute the shear strength of RC columns. According to the numerical findings, POLYREG-HYT and XGBoost-HYT-CV derived models outperformed other ML models in predicting the shear strength of rectangular RC columns with the correlation coefficient having a value R greater than 99% and minimal errors. It was also found that the newly proposed predictive model derived a 2-fold improvement in terms of the correlation coefficient compared to best available equation in the international literature.
EU Energy Law: Insufficient for the 1.5-Degree Celsius Limit
Authors: Ekardt Felix , Rath Theresa , Gätsch Cäcilia , Klotz Pierre Constantin , Heyl Katharine
Published: October 2024

This article examines the extent to which the current EU climate protection law fulfils the 1.5-degree limit from Article 2 of the Paris Climate Agreement. To this end, a qualitative governance analysis is applied. On this methodological basis, the main instrument for fossil phasing-out – the emissions trading scheme – and the promotion of hydrogen are discussed as examples. The results show that the EU must further intensify its efforts on its territory and cooperate with other countries since the reformed ETS 1 and ETS 2, the SCF and the CBAM are not sufficiently effective to stay within the 1.5-degree limit of the Paris Agreement. This is also the case with regard to hydrogen policies. The primary focus of energy law on the ETS is therefore fundamentally convincing; however, it should be implemented more consistently, for example in terms of the breadth of the approach, closing loopholes and the level of ambition.
Case Report: Successful Treatment of Solitary Fibrous Tumor with Selective Internal Radiation Therapy (SIRT)
Authors: Badran Omar , Dereza Sergey , Mireb Labib , Neeman Ziv , Bar-Sela Gil
Published: October 2024

This case report describes the innovative treatment of a 73-year-old woman with a Solitary Fibrous Tumor (SFT) using Selective Internal Radiation Therapy (SIRT) with Yttrium-90 resin microspheres. SFTs are rare tumors that pose significant treatment challenges, particularly in cases of recurrence or when the disease has metastasized. Systemic therapies often have limited effectiveness. In this case, the patient initially presented with a pelvic mass that was surgically resected, but she later developed metastatic disease in the liver. After experiencing severe side effects from targeted therapy with sunitinib, SIRT was chosen as an alternative treatment. Remarkably, the patient achieved substantial tumor reduction and symptom relief following this novel intervention. To our knowledge and following extensive literature search, this is the first documented instance of treating SFT with SIRT. It provides new insights into its potential as a therapeutic strategy, especially for cases where conventional treatments are inadequate or cause intolerable side effects. The success of SIRT, in this case, highlights its potential as a less invasive, locally targeted treatment option and may offer new hope for patients with similar conditions.
PoL Converter’s MTBF Calculation Using Prediction Standard MIL-HDBK-217F vs. SN 29500
Authors: Butnicu Dan , Bonteanu Gabriel
Published: October 2024

In Military, Medical, Space, Professional equipments design there is a need to be able to prove that the devices can last a certain length of time with a certain confidence level. Or that reliability must be used in design to inform the design direction, either through component selection, component testing and sort or in amelioration techniques (like redundancy, FEC - Forward Error Correction and so on). A higher level of reliability became a compulsory demand in modern DC-DC converters. Since the latest version MIL-HDBK-217F Notice 2 released in 1995, newer failure rate prediction standards had appeared on the electronic systems reliability market. These are introduced to compensate for the lack of the newest component technology in the above-mentioned standard. When it comes to reliability many studies have shown that the output capacitor bank is demonstrated to be the most critical component. In this work, the failure rate of an output capacitor bank and MOSFET transistor pair used within a high current low voltage buck converter is calculated both by the latest prediction standard SN 29500 and by with the previous standard MIL-HDBK, providing a comparison between the two which is a helpful tool for the output capacitor selection in the early stage design. Both simulation and experimental workbench set-up for the converter was used to detect the temperatures of the components. The SN 29500 standard is particularly useful for components used in harsh environments, providing up-to-date failure rate data and stress models. The components’ environmental conditions were defined by a standard PoL buck converter used for both calculation methodologies. Results are compared by taking account of the influence of the component’s temperature and application of specific parameters such as reference conditions and operating conditions.
The Legacy of Portuguese Miscegenation: Race, Social Stratification, and Brazil's Path to Development Compared to the United States
Authors: Montgomery Richard Murdoch
Published: October 2024

The colonization practices of Portugal, particularly its early and continuous encouragement of miscegenation, have profoundly shaped Brazil's social and racial landscape. This resulted in a racially mixed society with intricate social hierarchies where race, skin color, and socioeconomic status are deeply interwoven. Unlike the United States, which enforced strict racial boundaries through anti-miscegenation laws and a rigid binary classification of race, Brazil developed a more fluid and complex system of racial identification. This article delves into how Portuguese miscegenation influenced Brazil's racial identity and the formation of its elite, examines societal reactions to racial mixing, and contrasts these dynamics with those of the United States. By analyzing historical contexts, incorporating census data, and reviewing contemporary studies, the discussion highlights the systemic marginalization of Afro-Brazilians—who make up over half of the country's population—and how this exclusion impedes national development. The article argues that systemic racism is a critical barrier to Brazil's progress, potentially more detrimental than economic inequality and corruption, and emphasizes that integrating Afro-Brazilians is imperative for the nation to realize its full potential.
Acute Molecular Response Post ACL Injury: Connection to Ami and Motor Control
Authors: Kacprzak Bartłomiej , Stańczak Mikołaj
Published: October 2024

Anterior cruciate ligament (ACL) injuries are common, particularly among athletes, leading to significant functional impairment, prolonged rehabilitation, and an elevated risk of secondary complications. The ACL plays a critical role in knee stabilization, and its rupture initiates a cascade of molecular and neuromuscular changes that disrupt joint stability and motor control. One of the primary consequences of an ACL injury is the onset of Arthrogenic Muscle Inhibition (AMI), a neurological phenomenon characterized by reduced voluntary muscle activation, particularly in the quadriceps, resulting from altered afferent feedback, nociceptive inputs, and local inflammatory responses. The acute phase is dominated by pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, which propagate local inflammation, sensitize nociceptors, and disrupt both spinal and supraspinal motor pathways. This leads to central and peripheral sensitization, exacerbating AMI and impairing rehabilitation. As the injury progresses, an anti-inflammatory shift marked by IL-10 and IL-4 promotes tissue repair and resolution of inflammation. However, dysregulation in this transition can result in chronic inflammation and fibrosis, further complicating recovery. Understanding the temporal dynamics of these molecular mediators is essential for developing targeted interventions. This review explores the complex interplay between cytokine profiles and neuromuscular adaptations post-ACL injury, highlighting potential therapeutic targets and personalized rehabilitation strategies that could optimize functional recovery and mitigate long-term complications.
Papillary Tumor of the Pineal Region Treated with Surgery and Postoperative Radiotherapy; Literature Review and Case Description with Radiation Treatment Volumes
Authors: Royal-Preyra Benjamin , Boucher Mélanie
Published: October 2024

Papillary tumors of the pineal region (PTPR) are extremely rare malignancies usually treated with surgery and adjuvant tumor bed radiotherapy (RT). We present the case of a 69-year-old man diagnosed with PTPR after presenting with two weeks of confusion and ataxia. Imaging the head with computed tomography (CT) and magnetic resonance imaging (MRI) showed hydrocephalus and a 2 cm pineal region mass. We review the presenting symptoms, investigations, and differential diagnosis for patients with pineal region masses. The pathological features, including immunohistochemistry, are described with exemplative images. We report how the patient’s hydrocephalus was managed with medications and neurosurgical interventions, as well as the curative treatment of his tumor with surgery and postoperative tumor bed RT with 54 Gray (Gy) in 30 fractions. We also review the PTPR literature, including prognostic features and the evidence for treatment modalities. Few publications outline adjuvant radiotherapy planning treatment volumes, which are reported here. The patient was followed with a brain MRI every three months and is asymptomatic with no evidence of recurrent disease 18 months after surgery. PTPR has very high local recurrence rates following treatment and further research is needed to find more effective interventions and improve patient outcomes.
The Role of Pharmacometrics in Advancing the Therapies for Autoimmune Diseases
Authors: Świerczek Artur , Batko Dominika , Wyska Elżbieta
Published: October 2024

Autoimmune diseases (AIDs) are a group of disorders, in which the immune system attacks the body own tissues leading to chronic inflammation and organ damage. These diseases are difficult to treat due to variability in drug PK among individuals, patient responses to treatment, and the side effects of long-term immunosuppressive therapies. In recent years, pharmacometrics has emerged as a critical tool in Drug Discovery and Development (DDD) and precision medicine. The aim of this review is to explore the diverse roles that pharmacometrics has played in addressing the challenges associated with DDD and personalized therapies in the treatment of AIDs. Methods: The review synthesizes research from past two decades on pharmacometric methodologies, including Physiologically Based Pharmacokinetic (PBPK) modeling, Pharmaco-kinetic/Pharmacodynamic (PK/PD) modeling, Disease Progression (DisP) modeling, population modeling, and Quantitative Systems Pharmacology (QSP). The incorporation of Artificial Intelli-gence (AI) and Machine Learning (ML) into pharmacometrics is also discussed. Results: Pharmacometrics has demonstrated significant potential in optimizing dosing regimens, improving drug safety, and predicting patient-specific responses in AIDs. PBPK and PK/PD models have been instrumental in personalizing treatments, while DisP and QSP models provide insights into disease evolution and pathophysiological mechanisms in AIDs. AI/ML implementation has further enhanced precision of these models. Conclusions: Pharmacometrics plays a crucial role in bridging preclinical findings and clinical applications, driving more personalized and effective treatments for AIDs. Its integration into DDD and translational science in combination with AI and ML algorithms holds promise for advancing therapeutic strategies and improving autoimmune patient outcomes.
Supply Chain Waste Management Model: A Moderating Variable Between Sustainable Macro Ergonomics Process and Waste Management
Authors: Setyaningrum Ratih , Wismantoro Yohan
Published: October 2024

The implementation of waste management strategies informed by supply chain management methodologies may present a viable solution for the effective handling of waste, as exemplified by the waste management challenges observed in Indonesia. The waste management characteristics exhibited by each nation are inherently diverse, as they are influenced by various factors including supply chain management frameworks, the methodologies and technologies employed in waste processing, the cultural practices and behaviours of the populace regarding waste disposal, as well as the unique geographic conditions pertinent to each country. This study seeks to formulate a waste management supply chain framework that incorporates moderating factors influencing the relationship between sustainable macro ergonomic processes and waste management practices. The research methodology employed was purposive convenience sampling, encompassing a total of 224 participants engaged in waste management within the Semarang region of Central Java, Indonesia. The empirical results indicate that H2—TT exerts a statistically significant influence on RPPS (0.02 < 0.05), H3—TP demonstrates a significant impact on RPPS (0.001 < 0.005), H4—MGE displays a significant effect on RPPS (0.00 < 0.05), H5—seasonal floods (BM) reveal a significant effect on RPPS (0.001 > 0.05), and H6—cultural society (CC) manifests no significant impact on RPPS (0.755 > 0.05). The innovative aspect of this study lies in the finding that cultural society has not exerted an influence on waste management, whereas other macro ergonomic factors have shown a significant effect on this domain.
Effect of an Applied Magnetic Field on Joule Heating-Induced Thermal Convection
Authors: Hiremath Anupam Mahantayya , Yoshikawa Harunori Nakagawa , Mutabazi Innocent
Published: October 2024

Thermal convection induced by Joule heating in weak electrical conducting liquid such as molten salts with symmetric thermal boundary conditions is investigated using linear stability analysis. We show that the effect of the magnetic field consists on the delay of the threshold of thermal convection and show that for intense magnetic field, the size of thermoconvective rolls increases. Analysis of the budget of the perturbations kinetic energy reveals that the Lorentz force contributes to the dissipation of the kinetic energy.
Circular Economy in the Agri‐Food System at the Country Level. Evidence from European Countries
Authors: KHATAMI FAHIMEH , Cagno Enrico , Khatami Rayeheh
Published: October 2024

The circular economy is a tangible paradigm in response to the unsustainable model of production and consumption of resources in the agri-food system. The circular economy allows for a reduction in the environmental impact through the minimization of food waste or the maximal generation of renewable energy from waste. Despite the relevance, the extant literature is scat for indications on how to apply circular business models in agri-food systems. Hence, the paper aims to analyze the circular economy implementation level in the agri-food system in 29 European countries focusing on specific circular economy strategies. Selected indicators were analyzed to evaluate the level of circular economy implementation in the agri-food system (e.g., production values, energy sharing from renewable sources, and total waste emission) using a Panel data analysis method. The required variables were gained from the global databases within the recent five years (2014-2018). Results reveal an overall lack of circular economy implementation in the agri-food systems among European countries. A set of 12 managerial propositions was suggested to foster the implementation of the circular business models by interacting the recycling, extending, intensifying, and dematerializing strategies with aspects of the production process, waste emission, and renewable energy sharing in the agri-food system.
Health Risks Associated with Oral Contraceptive Pills: A Comprehensive Review of Complications and Safer Alternatives
Authors: Agrawal Roshan
Published: October 2024

Oral contraceptive pills (OCPs) are widely used for contraception and the management of various gynecological conditions, offering significant benefits to women’s health. However, their use is associated with a range of potential health risks, including cardiovascular complications, certain cancers, metabolic disturbances, and psychiatric effects. Despite these serious risks, the adverse effects of OCPs are often underappreciated or neglected in both clinical practice and public perception. This review explores the physiological mechanisms behind these complications, discusses the scope of the problem, and highlights the need for greater awareness and personalized healthcare. It also examines alternative contraceptive methods that may offer safer options for women, including intrauterine devices (IUDs), barrier methods, fertility awareness, implants, injectables, and permanent solutions. The review calls for improved patient education, risk assessment, and research into new non-hormonal contraceptive options to reduce the dependence on OCPs and minimize associated health risks.
Forest Development Alters the Compositions and Structures of Soil Macrofauna Communities in Reclaimed Coastal Lands
Authors: Cao Lili , Li Yuanyuan , Zou Xiaoming , Cao Jiajie , Wang Guobing , Ruan Honghua
Published: October 2024

Soil fauna is integral to facilitating material cycles, energy flows, and the conservation of biodiversity in terrestrial ecosystems. However, the impacts of forest development on the compositions and structures of surface soil macrofauna remain uncertain. Here, we assessed the dynamics in abundance and diversity of soil macrofauna across eight successional age stages of Metasequoia glyptostroboides tree plantations (7-, 16-, 21-, 26-, 31-, 36-, 41-, 46-year-old stands) in a reclaimed coastal land in China. The results revealed that the total abundance of soil macrofauna initially decreased during the young to near-mature stand period (7- to 31-year-old stands), whereas it increased along the age series, from the near-mature to overmature stand period (31- to 46-year-old stands). Specifically, the dynamics showed a U-shaped curve with stand development. Further, there was a significantly negative correlation between the Shannon-Wiener diversity index and the total abundance of soil macrofauna across this plantation chronosequence. The variations in abundance of detritivores were consistent with the total abundance of soil macrofauna during stand development. The abundance and diversity of the soil macrofauna were strongly correlated with the soil environment (e.g., soil organic carbon, litter biomass, and microbial biomass nitrogen). These findings highlight that the compositions and structures of soil macrofauna were significantly altered with M. glyptostroboides stand development. This provides important insights for studying the interconnection of above- and belowground plantation ecosystems toward their optimal management.
Bangladesh's Digital Evolution: Drivers, Impacts, and Future Opportunities
Authors: Rahman Md. Ashiqur , Parvin Rawnaq Ara
Published: October 2024

The Digital Bangladesh initiative is a comprehensive strategy aimed at transforming Bangladesh into a digitally advanced, economically competitive, and socially inclusive nation. This term paper explores the multifaceted causes and effects of the initiative, including the roles of government policies, economic imperatives, social factors, and technological advancements. The initiative leverages emerging technologies such as artificial intelligence, blockchain, and the Internet of Things to drive innovation, improve public service delivery, and enhance quality of life. Economic growth, improved governance, enhanced social inclusion, and environmental sustainability are key outcomes of this digital transformation. However, challenges such as cybersecurity threats, the digital divide, and infrastructural constraints must be addressed to sustain progress. Looking forward, the future prospects of the Digital Bangladesh initiative are promising, with potential for significant advancements in various sectors. By prioritizing strategic policymaking, fostering public-private partnerships, and ensuring sustainability and resilience, Bangladesh can realize its vision of becoming a Digital, prosperous, and inclusive nation.
Long-Acting, Longer-Acting and Ultralong-Acting Peptides
Authors: Schneider Eric , Hangasky John , Ashley Gary , Santi Daniel
Published: October 2024

This perspective describes the current status and future prospects of developing long- to ultralong-acting anti-obesity peptides. First, we review the current status of lipidation, PEGylation, and Fc fusion technologies to obtain long-acting peptides administered once weekly. Next, we describe the approach and current results of using macromolecular peptide prodrugs with pre-programmed releasable linkers to achieve longer-acting peptides that can be administered weekly or monthly. Finally, we posit novel modifications of the latter technology that could provide ultralong half-lives of over one month by advantageously exploiting the clearance rates of released peptides. As examples, we posit that prodrugs of low-clearance GLP-1 agonists derived from peptides already modified by lipidation, PEGylation, and Fc fusion could produce ultralong-acting agonists with dosing intervals reaching 3 to even 6 months.
Simulating Space Debris Removal Maneuvers: A Multi-Orbit Approach for Active Debris Clearance in LEO and GEO
Authors: Nuthalapati Rusheel Sai
Published: October 2024

The accumulation of space debris, including defunct satellites, rocket stages, and fragments, poses a severe threat to current and future space operations. Addressing this issue requires innovative approaches for active debris removal. This paper presents a new method for detumbling and deorbiting large, non-cooperative tumbling debris, such as those from Russian 'Kosmos 3M' launchers. We propose a detumbling device combining three harpoons with a nanosatellite, which attaches to debris and uses thrusters to reduce its angular velocity, facilitating subsequent removal. A high-fidelity coupled dynamics model of the system is developed to account for external disturbances and inertial changes due to fuel consumption. Additionally, an adaptive sliding mode control strategy with pulse-width pulse-frequency (PWPF) modulation is proposed to manage uncertainties and disturbances during the detumbling process. Numerical simulations demonstrate the effectiveness and robustness of the proposed method, achieving successful detumbling within 4000 seconds.