bluuebunny/crossref_metadata_2025 huggingface dataset:
Urban Inscriptions
Authors: Correa Thiago Moreira
Published: January 2025

We take into consideration the role of São Paulo city hall's public policies to reflect on the importance of integrating urban inscriptions in Higher Education disciplines in Brazil. According to the historical summary presented, the pendulum swing of rejection and acceptance by the mayors of São Paulo generates avoidable costs and the exclusion of an institutional approach regarding urban inscriptions practices. In order to have efficient public policies, we observed that the academic inclusion of themes specifically linked to urban inscriptions might result in support of professions that directly interact with the practices (Architecture, Urbanism, Arts, etc.); it can also increase the diffusion of knowledge in Basic Education, and highlight the need to institutionally integrating the urban inscriptions into the dynamics of cities and the citizenship formation.
Conceptual Post-Street Art in Russia
Authors: Polsky Anton
Published: January 2025

Global street art turned into a neo-pop(ulist) post-street art (inter)muralist movement operating with simple visual messages easily accessible for people via Instagram. Artists’ anti-capitalist pseudo-critical statements—what I call ‘protest for sale’— circulating in social media are easily co-opted by creative city discourse, the capitalist neoliberal system, discipline society, and the art market. Artists’ voices from peripheral scenes and regions dealing with local contexts, languages, and communities, and those who work in a more nuanced and sophisticated way are overshadowed by street art celebrities and their domesticated rebel aesthetics. Taking as an example Russian conceptual and dialogical post-street art I want to show other perspectives on the development of street art.
Developing a Qualitative Approach to the Study of the Street Art World
Authors: Boscaino Mattia
Published: January 2025

Street art is a complex social phenomenon where many actors contribute to determining the value of creativities. Street artists, curators, bloggers, photographers, museums, galleries, the public, and other actors interact with street artworks and influence the way they are perceived. In this context, it is clear that both the value and meaning of street art is not exclusively dependent on the intentions of the authors but changes according to who views and uses the artwork for their purposes. Although diversity is interesting for the sake of research, finding a research methodology able to comprise the diverse perspectives briefly illustrated above, can be difficult.
A multi-method qualitative study conducted between the 2017 and 2019, attempted to include many aspects of the social structure of street art in order to understand how street artworks become renowned in the digital era. The study proved to be useful to cover many of the various perspectives of some of the actors mentioned above. Indeed, data collection consisted in conducting semi-structured interviews as well as analysing digital conversations where street artworks are viewed and discussed by both professional and amateur audiences. Semi-structured interviews were conducted with street artists, street art curators and street art connoisseurs - bloggers, administrators of digital platforms, photographers, etcetera - while digital conversations were considered in order to grasp the significance of the interactions happening between the street artwork and its audience(s), amongst street artists, and within the digital audience. Analysing the data via thematic analysis revealed a multi-dimensional structure of the street artworld and allowed an understanding of how street artworks become renowned in the digital era as well as contributed to the theory of co-creation in the arts. This methodological approach allowed including different professional and personal perspectives, as well as integrating the personal accounts of actors with the observation of in situ interactions.
A Study Of Parklet Planning, Design And Planting Criteria Examples In Izmır And Istanbul
Authors: Yücel Caymaz Gökçen Firdevs , Zerriouh Mohammed Abderraouf
Published: January 2025

The objective of this study is to research the planning, design, planting and maintenance requirements of a quality parklet by means of the examples of Izmir and Istanbul parklets in Turkey. In this regard, planning and design (important elements=wheel stops, flexible posts, raised platform/recommended elements=open guarded-railing, the sub-structure/urban furniture=flooring, seating, lighting, bicycle stands, shades, art, signage), as well as planting and maintenance were tested on two example parklets with a checklist created using on-site detection, photography and observation methods. As a result of the research in question, it was concluded that the use of reflective surfaces and wheel stoppers critical for safe usage are insufficient in parklet designs; that vertical elements don’t meet the minimum usage standard; that there are no lighting, trash, art and game elements in neither area; and that it was determined the Istanbul parklet example was insufficient in terms of shade and planting compared to the Izmir example.
Spatial Video Projection as a Digital DIY Paradigm for Under-valued Public Open Spaces Revitalization
Authors: Najjar Lima , Turer Baskaya Fatma Aycim
Published: January 2025

This study suggests a digital model for revitalizing undervalued public open spaces (UVPOS) as one of the contemporary cities' phenomena. It discusses spatial video projection (SVP) as a digital do-it-yourself (DIY) paradigm for UVPOS revitalization. The application of tricycle SVP is suggested as a model for this paradigm. As a result, this research conceptualizes the SVP as a digital DIY paradigm for UVPOS revitalization and identifies the main components that must be achieved and integrated with the city's official planning and design systems.
The Role of Street Art in Sustainable Development: Art and Social Change
Authors: Hansen Susan
Published: January 2025

This paper explores the potential role of street art in making a meaningful contribution towards the UN’s Sustainable Development Goals (SDGs) via a review of the academic literature and a series of case studies of existing street art initiatives that demonstrate the alignment of this form of art with the SDGs and the 5 P’s of the UN Agenda 2030: People (social), Planet (environmental), Prosperity (cities and economies), Peace, and Partnerships. I also examine the impact of visual forms of communication about sustainability issues, as a powerful means of “synthesizing complex information, portraying new ideas, prompting thought and dialogue, and rapidly conveying ideas” (Nicholson-Cole, 2005: 32). The paper concludes with a focus on the first organised initiative, internationally, to address the Sustainable Development Goals though street art. TOward2030: WHAT ARE YOU DOING? (Lavazza, 2019-2021) represents the first comprehensive street art-based project that aims to address and raise awareness of all 17 SDGs. Building street art culture’s awareness of the complex issues raised by the SDGs, encouraging artists to reflect on sustainability issues in their existing practice, and developing creative networks to include a wider range of stakeholders may augment the capacity of street art to make a significant contribution to progress towards the SDGs.
Street Art and the Struggle for Public Space
Authors: Muttaqin M. Zaenul
Published: January 2025

The film entitled "Coretan Seni Dibalik Vandalisme" is an Indonesian-language documentary film that offers street art from a broader perspective, beyond the values ​​of legality and democracy. The views of artists, observers, and academics are important to capture the reorientation of street art which has been commonly called vandalism.
Istanbul Taksim Republic Monument as an example of public art
Authors: Erarslan Alev
Published: January 2025

Statues erected in public spaces are important elements of city squares and also represent traces of culture that are transferred into the future. These monuments are sometimes built for purposes of propaganda and at other times to commemorate a particular event, but whatever the reason for their creation, they are significant  structures that serve as  points of  social interaction within the communities of which they are a part. When their relationship with the environment is firmly established, these monuments also assume an urban identity. The founder of modern Turkey, Mustafa Kemal Atatürk, wished to have the establishment of the new political model and the “nation state” emerging with the proclamation of the Republic (29 October 1923) symbolized through the language of architecture. Thus, as he promoted the slogan of “reaching the level of contemporary civilization,” he expected to have this concept reflected in architecture as much as possible in the physical sense during the Republican period of institutionalization. Part of his plan to achieve this was to create and activate public spaces in the urban landscape. This led to the monumentalization of the art of sculpture and to the appearance of the city squares of modern Turkey, where the statues that were the works of art displayed in these public spaces came to represent Atatürk and the newly established social order. This article aims to analyze how one of the symbols of Turkish architecture and of the Republican Period, the Taksim Republic Monument in Taksim Square, Istanbul, took shape as a public monument, and attempts at the same time to describe its social relationship with the surrounding environment.
Identifying the pleasant sounds in the city's public parks environment (Case study: Mellat riverside park, Urmia)
Authors: Ghalehteimouri Kamran Jafarpour , Shamsoddini Ali , Bayramzadeh Nima , Mousavi Mir Najaf
Published: January 2025

Noise pollution is a prevalent issue in contemporary public spaces, leading to discomfort and mental distress in individuals. This study aims to improve the quality of soundscape in urban public spaces and enhance the comfort and well-being of citizens. Using a mixed-methods approach, including literature review, field observations, questionnaires, and interviews, the research was conducted at Mellat Park in Urmia, Iran. The sample consisted of 170 randomly selected park visitors, who were surveyed to gather data. The findings indicate that the majority of visitors prefer the use of music in public spaces but emphasize the importance of a balanced audio environment. The results further reveal that natural sounds were found to be the most preferred type of sound, as they provide a sense of leisure, relaxation, and calmness. This study highlights the significance of creating a harmonious soundscape in public spaces to improve the overall experience and comfort of citizens. The low level of Sig, Water sound, Car sound, Speakers sounds, Types of treble sounds, and Types of bass sounds differs significantly from the average level due to the positive upper and lower 95% confidence in the water sound, this value is also higher than the average. Because of the negative upper and lower 95% confidence levels in the car sound, speakers sounds, types of treble sounds, and types of bass sounds, this value is lower than the average level.
potentials of graffiti in opposing the women economic oppression: The Kosova case
Authors: Krasniqi Artan , Haxhiu Agnesa
Published: January 2025

Urban art in general, and graffiti in particular, has a multitude of artistic, cultural and social effects. Numerous studies explain its multidimensional role. This article specifically aims to address the potential that graffiti has in expressing revolt and opposition to the women economic oppression. Finally, the feminist movement in Kosova has started to use graffiti as a tool to raise concerns about the position of women in society. The study objective of this article is the graffiti that shows discrimination against women as the workforce on three levels: unpaid work, paid work at the public sector, as well as the illegal exploitation of paid work in the private sector.
Evaluation of Furniture Designs in Science Fiction Movies; Star Wars Example
Authors: Ardatürk Ahmet Sadi
Published: January 2025

Both the phenomena of watching and being watched and furniture design are as old as human history. Today, it can be easily stated that the most fundamental provider of the phenomena of watching and being watched is the field of cinema, and the most major form of the relationship established with the visual is the art of cinema. Furniture, on the other hand, appears as a basic equipment used in the field of cinema. In this context, it can be stated that furniture, as a basic equipment used in cinematic works, is a part of the integrity of cinema and is one of the paradigms that constitute this integrity. Similar to many design fields such as editing, make-up, character in the art of cinema, it can be stated that furniture design (especially affecting the design and service of the stage) is a situation that can establish a direct connection with the user. The issue of furniture design in the art of cinema is taken very seriously by many directors.
This study includes a research that evaluates, analyzes and interprets the furniture designs that exist in the art of cinema through the science fiction genre. The main films of the world-famous Star Wars universe were selected as the sample. The main reason for this selection is that, although the furniture related to the depiction of the reality existing in period cinemas contains a known design core, the furniture relationship in futurist works is a new design element. At this point, the relationship between furniture and the Star Wars universe, in which hundreds of works have been produced within a futurist scenario, has been questioned.
A joint research has been carried out in the context of both design history, aesthetic knowledge and futurism with semantic, semiotic, functional and ergonomic analyzes. The general structure of the study is formed by discussing both the discourses of the furniture in the works and their functional, ergonomic and semiotic meanings. The study, which exists at the intersection of cinema and furniture design, reveals the relationship between the work-scenario-furniture by measuring the suitability of furniture designs in the context of futurism. As a result, design nuclei that will create a critical attitude towards the related works have been discovered.
Comics meets street art in the media cities of the bande dessinée. Examples from Brussels and Geneva
Authors: Muranyi Kata , Maksa Gyula
Published: January 2025

Comic media exists in historical and geocultural variations. The historically dynamic identity formation of comic media in some geocultural versions is accompanied by the emergence of mediatic hybridisations that manifest themselves in a street art activity. In this article, we examine these comics-based hybrid media and their use from a media theoretical perspective in the context of two different media cities of the Francophone bande dessinée. In Brussels and Geneva, the institutionalisation of comics has been partially different, but both cities have seen a significant role in hybrid media related to street art. In Brussels, this is the case with comic murals, which have a canonising function and also generate tourist activity. In the case of Geneva, the importance of comic posters and comic-style street signs linked to political communication, civic education, and campaigns by NGOs is striking.
Aesthetic Activism and the Carnivalesque in the Urban Social Movements
Authors: Tunali Tijen
Published: January 2025

This paper considers the ways in which changes and experimentations in the realm of aesthetics ,as well as in the new forms of political participation and representation in an era of global revolt, have resulted in a deep connection between the aesthetics and politics of civil disobedience, political activism and artistic representation. Specifically, the discussion is based on a comparative analysis of the urban activism of the Carnival Against Capital protests in London and Seattle, the Occupy Movement in New York, and the Gezi Park Movement in Turkey where the aesthetics of active participation represents a new kind of politicization—collective memory and language, sensual festivity and the forming of communitas—that goes beyond the conventional understanding of the convergence of politics and art.
The author focuses on the notable carnivalesque character in those protests—the costumes, the masks, the performances, the interventional tactics and the aesthetics of community building. Based on the theories of aesthetics and rebellion the paper proposes the concept of carnival aesthetics as the study of the sensuous and subversive experience of the multitude when marching, throwing slogans, battling with police forces behind the barricades, performing and dancing together on the streets. Here carnivalesque aesthetics are employed as a means to create diversity, creativity, decentralization, horizontality, egalitarianism and direct action—the political principles that are at the heart of the recent protests. The discussion demonstrates that while thriving authoritarianism depends on disciplined individuals and the crisis in democracy, carnival aesthetics during protests present radicalized social relations that are increasingly becoming the core of the current social, cultural and environmental struggles around the world.
Chickenpox and herpes zoster: dynamics of incidence and approaches to prevention
Authors:   Associate Professor, Department of Epidemiology, Irkutsk State Medical University, Ministry of Health of Russia, Bayanova T.A. , Zaikova Z.A. ,   Associate Professor of the Department of General Hygiene, Irkutsk State Medical University of the Ministry of Health of Russia
Published: January 2025

The dynamics of the incidence of chickenpox and herpes zoster in the population of the Irkutsk region and the city of Irkutsk against the background of ongoing selective vaccination was studied. A descriptive epidemiological study was conducted according to state statistical reporting based on materials from the Irkutsk region and the city of Irkutsk for 2013-2022. The calculation of predictive values was made using regression equations, the statistical significance of differences in intensive indicators was assessed by 95% CI. Against the background of a decrease in the incidence of chickenpox, in 2021-2022. There was an increase in the indicator among different age groups of the population, the most significant among children under 6 years of age. According to the forecast, in 2023 the incidence rate will not change significantly. Selective vaccination tactics do not significantly affect the incidence of chickenpox (p = -0.217; -0.7; p>0.05). The incidence of shingles in the region exceeds the national level. Taking into account the continuing epidemiological trouble for chicken pox in the region and the data of forecast calculations, it is necessary to adjust the existing vaccination programs, including gradually expanding the contingents to be vaccinated.
Keywords: chicken pox, shingles, incidence, vaccination.
The role of preventive examinations in the early rehabilitation of musculoskeletal diseases of children and adolescents
Authors:   Dr. Sci. in Medicine, Professor, Astrakhan State Medical University, Bashkina O.A. , Shapovalova M.A. ,   Dr. Sci. in Medicine, Professor; Astrakhan State Medical University, Romankova J.N. ,   Assistant, Astrakhan State Medical University, Bobyr E.O. ,   Deputy head of the hospital; State Budgetary Healthcare Institution of the Astrakhan region, N. Silishchev Regional Children's Clinical Hospital
Published: January 2025

Based on the analysis of the results of preventive examinations of children and adolescents of the Astrakhan region for the period from 2015 to 2021, it was revealed that, despite the steady increase in detected cases of diseases of musculoskeletal system (MSS), the percentage of those placed on dispensary registration is constantly decreasing, which violates the target requirements of current regulatory documents at both federal and regional levels.Together with the negative impact of covid restrictions on the volume of preventive examinations, it seriously worsens the situation with the timely implementation of rehabilitation measures for MSS diseases.The negative consequences for the health of the sick will progress as they grow up, which will lead to serious economic damage to society as a whole.
It is proposed to increase the percentage of children being registered at the dispensary with MSS diseases, even if at the time of the examination they have the form of functional abnormalities with the risk of transition to the chronic phase; to expand the rehabilitation infrastructure by creating a specialized center, or significantly improving the equipment of existing medical institutions, to promote measures of self rehabilitation and prevention of MSSdiseases among children and youth.
It is proposed to increase the proportion of children with MSS diseases taken under observation at the early stages of the disease, even if at the time of preventive examination they have only the form of functional abnormalities with the risk of transition to the chronic phase; to expand the rehabilitation infrastructure by creating a specialized center, or significantly improving the equipment of existing medical institutions, to promote measures of self-rehabilitation and prevention of MSS diseases among children and youth.
Keywords: preventive examination, dispensary registration, rehabilitation, effectiveness, children, musculoskeletal system.
Biological markers in predicting the course of spinal muscular atrophy and their importance in organizing medical care
Authors:   Head of the laboratory, International Centre for Education and Research in Neuropsychiatry, ICERN, Samara State Medical University, Samara, Gaiduk A.Ya. , Syunyakov T.S. ,   PhD, senior researcher of the International Centre for Education and Research in Neuropsychiatry, ICERN, Samara State Medical University, Gazheva A.V. ,   PhD, Associate Professor, head of the Department of SBI Scientific Research Institute of Health Organization and Medical Management of the Department of Health Moscow, Makhanova E.F. ,   neurologist of the State Medical Institution S.M. Kirov City Polyclinic No. 1, Ulyanovsk, Vlasov Ya.V. ,   MD, Professor of the Federal State Budgetary Educational Institution of Samara State Medical University, Samara
Published: January 2025

А correlation between the levels of blood biomarkers and clinical manifestations of SMA in patients of the main regional healthcare institution of the Samara region was carried out.
Differences in creatinine, creatine phosphokinase, and lactate dehydrogenase levels among patient groups and their association with motor impairment did not show statistical significance. Differences in CPK levels between groups may be related to age, weight, gender, and levels of physical activity of patients. The data obtained from the study of the history of repeated hospitalizations do not provide reliable information due to the limited sample and heterogeneity of the data. The results of this work indicate the ineffectiveness of assessing the levels of creatinine, CPK and LDH in order to monitor and predict the course of SMA, as well as the inappropriateness of repeating these laboratory studies in patients with SMA 5q.
Keywords: creatine phosphokinase, creatinine, neurofilament, neuromuscular diseases, nusinersen, hereditary disease, pathogenetic therapy, risdiplam, spinal muscular atrophy.
МОДЕЛИРОВАНИЕ ДИНАМИЧЕСКИХ ПРОЦЕССОВ В ПЛАЗМЕННОЙ СВЕЧЕ ЗАЖИГАНИЯ ГТД
Authors: САЛИХОВ Р М.
Published: January 2025

По результатам экспериментальных исследований на специальном стенде, имитирующем различные факторы при возможных режимах запуска ГТД, влияющие на надежное дугообразование в плазменной свече зажигания, разработана газодинамическая модель, позволяющая предварительно проводить оценку влияния геометрии плазменной свечи зажигания и места ее установки в камеру на динамику плазмообразующего потока воздуха через плазменную свечу зажигания и сносящего потока для оценки максимально возможного выброса плазменной дуги.

Based on the results of experimental studies on a special stand that simulates various factors in possible gas turbine engine startup modes that affect reliable arcing in a plasma spark plug, a gas-dynamic model has been developed that allows a preliminary assessment of the influence of the geometry of the plasma spark plug and the location of its installation in the chamber on the dynamics of the plasma-forming air flow through the plasma spark plug and drift flow to assess the maximum possible plasma arc ejection.
The Cost Analysis of Green Construction Implementation in The Building Construction Project of The Institut Teknologi dan Bisnis Sabda Setia Pontianak
Authors: Dumanauw Stefani , Lusiana Lusiana , Syahrudin Syahrudin
Published: January 2025

Building construction projects often face challenges during construction and operation. Implementing green construction is a promising solution to enhance process efficiency. Green construction involves planning and executing projects focusing on efficient energy, water, cost usage, and construction waste management. This study analyzes the additional costs of applying green construction to the Institut Teknologi dan Bisnis Sabda Setia (ITBSS) building in Pontianak. Using market price data and Work Unit Price Analysis (AHSP), the estimated additional cost for implementing green construction indicators is Rp34,122,728.55. These costs include energy and water conservation, air quality, and environmental management. However, utilizing recycled materials reduces costs associated with land use. Green construction enhances project sustainability and efficiency, leading to significant long-term savings. While this research highlights the additional costs, it does not provide a detailed calculation of long-term benefits. The findings suggest that green construction practices are viable and sustainable, urging stakeholders to embrace these practices for improved project performance and environmental impact.
Optimal power-law fluid flow in tree-like branching network with self-similar and uniform roughness models
Authors: Fontana J. V. , Garg Ashish
Published: January 2025

This study presents an analytical model for the flow of a power-law non-Newtonian fluid through a roughened tree-like branching network under volume and surface area constraint. We assume steady-state, axisymmetric, and laminar flow with non-slip boundary conditions along the network walls. We investigate two different roughness models (1) a self-similar roughness length scale aligned with the branching network pattern, and (2) a uniform roughness length scale and compare the results. We find that in case of the self-similar roughness model, the effective conductance remains the same as that of the smooth channels forming the network. However, in case of the uniform roughness model, the effective conductance presents an overall decrease. We argue that the uniform roughness model is a more realistic one. Further, the optimal effective conductance and the critical geometrical scaling parameter, such as diameter ratio, are analyzed as functions of network geometry and fluid rheology with power-law index. Under both volume and surface area constraint, increasing geometrical parameters such as daughter branches and network generations generally reduced optimal effective conductance, especially for shear-thickening fluids, while shear-thinning fluids were less affected. In macroscopic networks where roughness is relatively small, its effect on the optimal effective conductance is negligible; however, in microscopic networks, where roughness approaches the scale of the smallest channels, it leads to pronounced conductance reduction. Further constrained surface area shows significantly lower optimal effective conductance values compared to volume-constrained systems. Furthermore, we find that uniform surface roughness model predicts the scaling laws for optimal flow varying with all geometrical and rheology parameters. Moreover, in the case of self-similar roughness, the scaling laws for optimal flows are the same as those for the smooth network. These are the function of the branch-spitting number N, for volume constraint, and for both N and n, for surface area constraint. For macroscopic networks under the uniform roughness assumption, an approximation for the critical geometrical scaling parameter was derived using linearization with respect to the roughness intensity parameter, and it was found in good agreement with the full model equations.
Stereoselective Synthesis of Mirogabalin via 1,4-Selective Addition of Lithioacetonitrile to Alkylidene Malonate
Authors: Ochiai Hidenori , Mihara Taiki , Sasagawa Miwa , Nishiyama Akira
Published: January 2025

The synthesis of mirogabalin was studied for industrial production, and an alternative to the Daiichi–Sankyo’s method was established. The developed synthesis involves the introduction of a two-carbon unit with the stereoselective 1,4-selective addition of lithioacetonitrile to alkylidene malonate and one-carbon degradation by Hofmann rearrangement. The precursor for the Hofmann rearrangement was readily prepared from the 1,4-adduct via a one-pot reaction involving decarboxylation, hydrolysis, and hydration.
Theory-guided design of Pd-catalysts for nondirected C-H functionalization governed by noncovalent interactions
Authors: Romero Kristen W. , Mao Yuezhi
Published: January 2025

The development of selective catalysts for nondirected C-H functionalization remains a critical challenge in organic synthesis. In this study, we present a computational framework for designing PdIV-based catalysts for nondirected meta-selective C-H activation of anisole, with a focus on ligand design for the Pd complex. Among the ligands surveyed, the pyrazolo naphthyridine (PzNPy) ligand was predicted to exhibit both higher reactivity and selectivity for meta-C-H activation compared to other ligands, as evidenced by its lower overall and relative (meta vs. para) Gibbs free energy barriers, respectively. Energy decomposition analysis (EDA) highlighted the importance of noncovalent interactions, particularly the frozen interaction components (permanent electrostatics, Pauli repulsion, and dispersion), in determining the selectivity trends. Systematic modification of the PzNPy ligand in silico by introducing various electron-donating or electron-withdrawing substituents revealed that while changes to substituents do not significantly affect the selectivity of the catalyst, they do have a pronounced effect on its reactivity. Furthermore, we observed a strong correlation between the Hammett sigma meta (σm) constant of the substituents and the enthalpic contributions to the free energy barrier (∆H‡meta), highlighting how the electronic effects of substituents influence reactivity. Further analysis also revealed a strong correlation between ∆H‡meta and the strength of electrostatic interaction evaluated at the intermediate reactant complex that forms prior to the transition state, providing insights into the enhanced reactivity associated with electron-withdrawing substituents on the PzNPy ligand. Our results demonstrate the potential to enhance both the reactivity and selectivity of catalysts for non-directed C-H functionalization through rational ligand design.
Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a pan-degrader
Authors: Feller Felix , Weber Heiko , Miranda Martina , Honin Irina , Hanl Maria , Hansen Finn Kristian
Published: January 2025

Proteolysis-targeting chimeras (PROTACs) have recently gained popularity as targeted protein degradation (TPD) promises to overcome the limitations of occupancy-driven pharmacology. However, most degraders rely on a small number of E3 ligases. In this study, we present the first-in-class histone deacetylase (HDAC) PROTACs recruiting the DDB1- and CUL4- associated factor 11 (DCAF11). We established a synthesis route entirely on solid-phase to prepare a set of eleven degraders. The long and flexible spacer bearing FF2039 (1j) showed significant HDAC1 and 6 degradation in combination with cytotoxicity against the multiple myeloma cell line MM.1S. Further investigations revealed that 1j was also able to degrade HDAC isoforms of class I, IIa and IIb. Compared to our previously published cereblon-recruiting HDAC6 selective PROTAC A6, we succesfully transformed the selective degrader into a pan-HDAC degrader by switching the recruited E3 ligase. A detailed profiling of the anticancer properties of 1j demonstrated its significant antiproliferative activity against both hematological and solid cancer cell lines, driven by cell cycle arrest and apoptosis induction.
Triggered ‘capture-and-release’ enables a high-affinity re-binding strategy for sensitivity enhancement in lateral flow assays
Authors: Ho Chapman , McMahon Clíona , Ayrton John-Paul , Chudasama Vijay , Thomas Michael
Published: January 2025

Lateral flow assays (LFAs) are point-of-care devices known for their affordability, speed, and simplicity. However, their sensitivity is often limited due to the need for fast associative rates between assay components. This work presents a strategy towards reducing the demand for fast test line associative kinetics via a ‘capture-and-release’ approach. Using a HER2 model antigen system, this methodology – termed the “AmpliFold” approach – involves the initial sequestration of analyte-bound complexes which undergo triggered release and are re-bound, using high-affinity hapten interactions, for enhanced signal-to-noise detection. Using anti-HER2 Fab fragments modified with cleavable biotin linkers to achieve triggered release, the importance of linker length and protein modification strategy on the efficiency of analyte-bound complex release is described. Cleavable Fab fragment conjugates were combined with ‘dual-affinity’ gold nanoparticles (AuNPs) highly decorated with fluorescein-tagged anti-HER2 antibodies to facilitate signal amplification. The utility of the AmpliFold approach is demonstrated by titrating capture receptor density to modulate signal distribution across test lines. Larger capture areas in the AmpliFold approach were shown to overcome poor capture kinetics associated with low receptor densities, achieving up to a 16-fold improvement in limit of detection. The AmpliFold approach was further shown to address the poor diffusivity and surface binding kinetics of large nanoparticles in sensitive LFA systems. Using high capture receptor densities and a 150 nm AuNP example, a 12-fold sensitivity enhancement was achieved when comparing AmpliFold to traditional LFAs for the detecting of antigen spiked into both buffer and human serum samples. Incorporated into a manually-assembled ‘folding’ LFA design, the AmpliFold approach represents a proof-of-concept strategy which utilises established protein modification chemistries to provide a rapid (within 30 minutes), equipment-free and tractable route towards enhancing LFA kinetics and sensitivity.
Investigation of Optimum Geometry for Robotics Torque Sensor
Authors: Mahadik S. C. , Deulgaonkar V. R. , Washimkar D. N. , Sarje S. H. , Bhosle S. M. , Vetal S.
Published: January 2025

Purpose: This study aims to optimise the geometry of joint torque sensors to enhance sensitivity and precision while minimising stress.
Design/Methodology/Approach: The research involves designing and evaluating three-ring geometries (Ring A, Ring B, and Ring C) under varying rib angles (30°, 45°, 60°, and 90°) using Finite Element Analysis (FEA) in ANSYS. Experimental validation was performed on the geometry with the highest stress (Ring C, 60° rib angle), utilising strain gauges for stress measurement.
Findings: FEA revealed that Ring A and B geometries exhibited lower stress levels, with Ring A being the most favourable. While showing higher stress, Ring C demonstrated suitability for applications requiring precise strain measurements.
Research Limitation: The study focuses on aluminum alloys 6061 and 7075-T6.
Practical Implication: Optimised torque sensors can enhance robotic applications requiring precise force measurement and control, improving operational safety and precision.
Social Implication: Enhanced torque sensor design supports safer and more efficient robotics and benefits society by enabling technological advancements.
Originality/Value: This work comprehensively evaluates torque sensor geometries, combining FEA and experimental validation to identify designs that balance stress minimisation and measurement precision, contributing to advancements in robotic sensor technology.
¿Hacia dónde van los cannabinoides? La despenalización y las posibilidades de innovación en México
Authors: Viguri Castellanos Rodolfo Federico , De Hoyos Bermea Adalberto
Published: January 2025

El objetivo de esta investigación es analizar la historia que ha tenido México con relación a los cannabinoides y su vínculo actual como fármacos o como elemento dentro de los circuitos de investigación, experimentación y producción de los mismos. Mediante un análisis cualitativo de los proyectos de ley y artículos relacionados se busca comprender si es posible o no que estas legislaciones fomenten temas de innovación en el mercado farmacéutico mexicano, y como una de las principales consecuencias, la oportunidad de innovación se puede ver mermadas. En el proceso de despenalización poco se ha realizado para eliminar los estigmas asociados a la planta Cannabis sativa L. alargando las limitaciones al uso de los derivados de dicha planta, que puede generar beneficios generales en la salud sobre todo en temas de dolor o enfermedades específicas a la población mexicana. La originalidad de este proyecto radica en el estudio de los fármacos cannabinoides desde su potencial tras una despenalización y sus formas de incorporarse a circuitos de medicamentos, y concluyendo que la legislación actual, solo permite las investigaciones científicas y el uso clínico limitado de los fármacos cannabinoides permitiendo entrever las áreas de oportunidad para la comercialización de medicamentos y estímulo de investigaciones científicas.
Estudio bibliométrico de la responsabilidad social universitaria
Authors: Wendlandt Amézaga Teodoro Rafael , Ramos Zayas Ana Carolina , Buelna Peñuñuri Ramiro Arnoldo , Navarro Arvizu Elba Myriam , Vásquez Torres María del Carmen
Published: January 2025

La presente investigación se propuso conocer las características bibliométricas que presentan los artículos científicos publicados sobre la RSU, esto mediante los criterios de año de publicación, revista, autoría, naturaleza, metodologías y perspectivas o enfoques empleados, esto para contribuir al conocimiento sobre esta temática.
La naturaleza de estudio que se implementó fue un estudio bibliométrico que corresponde a la metodología cuantitativa bajo un alcance descriptivo, para lo cual se recolectó y analizó la información de una muestra total de 280 artículos en un periodo temporal desde el 2002 al 2022. Como principales resultados, se obtuvo la Revista Opción y Revista de Ciencias Sociales. Cabe destacar que los países con revistas de alto impacto pertenecen principalmente a Iberoamérica, mientras que las restantes se encuentran clasificadas como de mediano impacto y solamente una revista se clasificó como de bajo impacto. De igual manera, en relación con los autores y la universidad de afiliación, la Universidad del Zulia en Venezuela fue la de mayor presencia, además que los autores que más publicaron sobre la RSU fueron Ricardo Andrés Gaete Quezada y Juan José Martí-Noguera.
Con respecto a las características de los artículos analizados, se observó que la mayor parte pertenece a la naturaleza empírica, y la metodología más utilizada fue la cualitativa bajo el diseño de investigación documental; el alcance con mayor representación fue el descriptivo y la perspectiva más representativa fue la de los estudios de la RSU desde diversas perspectivas. El presente estudio representa un precedente para futuras líneas de investigación de la RSU.
Algoritmo Criptográfico basado en Curvas Elípticas para la Generación de Llaves, Encriptado y Desencriptado
Authors: Hernández Salmerón Guadalupe , González Gutiérrez Fidel , Chávez Barrios Pedro
Published: January 2025

El objetivo principal de este manuscrito es presentar un algoritmo criptográfico basado en curvas elípticas con una mejor eficiencia en el espacio de almacenamiento para las llaves y el tiempo de ejecución en aplicaciones de seguridad. La metodología de investigación se basa en una serie de funciones específicas, desde la generación de llaves hasta el proceso de codificación y decodificación de datos, utilizando operaciones matemáticas en curvas elípticas. Los resultados más destacados se centran en la eficiencia demostrada en términos del uso de espacio de almacenamiento para las llaves y tiempo de ejecución, lo que contribuye significativamente a la optimización de los recursos en sistemas de seguridad de la información. Aunque se reconocen ciertas limitaciones y consideraciones en la elección de parámetros y llaves, la originalidad y el valor de esta investigación radican en su capacidad para mejorar la eficiencia en la protección de datos sensibles, este estudio concluye que la criptografía de curvas elípticas ofrece una solución efectiva para abordar los desafíos del almacenamiento de llaves y el rendimiento, lo que resulta en una mejora significativa en la eficiencia de los sistemas de seguridad de la información.
Analysis of nicotinic acid in coffee using the temperature programmable
injection method in gas chromatography-mass spectrometry
Authors: Aprilia S.A. , Wonorahardjo S. , Utomo Y.
Published: January 2025

Nicotinic acid is found in various kinds of food, including coffee. The gas
chromatography-mass spectrometry (GC-MS) method is currently being developed to
analyse the presence of thermal decomposition of the compound during elution. The
temperature programmable inlet (TPI) was carried out to optimise the sample recognition
and separation, protecting samples from thermal degradation by balancing efficient
vaporisation and minimal fragmentation during ionisation. This study aimed to determine
whether GC can analyse nicotinic acid from other compounds. The TPI-GC/MS found
nicotinic acid, in the form of pyridine-3-carboxylic acid, 1-[bicyclo[4.1.0]heptane-7-
carbonyl)amino]-6-oxo-1,6-dihydro-, methyl ester. The compound pyridine-3-carboxylic
acid which is another name for nicotinic acid was found at an injection temperature of
240°C.
Формування інноваційної бізнес-моделі в умовах сучасних реалій
Authors: Sviridenko Valeriia , Gryshko Volodymyr
Published: January 2025

У статті систематизовано і узагальнено існуючі проблеми в побудові інноваційних бізнес-моделей в умовах сучасних реалій, здійснено аналіз підходів до визначення поняття «інноваційна екосистема», визначено потенціал та запропоновано рекомендації щодо вдосконалення та стимулювання вітчизняного інноваційного процесу. Модернізована економіка сьогодення має властивість взаємозалежних окремо діючих економічних контрагентів саморегульованої інноваційної екосистеми, яка має швидко реагувати на зміну кон’юктури ринку та попиту споживачів, має властиві гнучкі галузеві принципи організації виробництва та чітко структуровані процеси розробки, виходу на ринок, виробництва та сервіс реалізованої продукції потенційним споживачам. Існує різниця між традиційною моделлю створення цінності, заснованою на співпраці провідних бізнес-стейкхолдерів, і формуванням бізнес-моделей інноваційних екосистем на спільній платформі відкритих інновацій. Основні фактори ефективності інноваційних екосистем визначаються ступенем сформованості інноваційних бізнес-моделей мікродиверсифікованих компаній, що відображають якість взаємодії зацікавлених сторін, реалізують цифровізацію технологій та охоплюють економічний розвиток.
Маркетингові технології просування органічної продукції в умовах цифровізації
Authors: Pakhucha Elina , Chmil Hanna , Olinichenko Kateryna
Published: January 2025

Органічний продовольчий ринок є найбільш стабільно зростаючим ринком в останні десятиліття, який привертає увагу все більшої кількості виробників та споживачів, а пандемія COVID-19 тільки посилила позиції органічних харчових продуктів. За даних умов споживачі все більше уваги почали надавати власному стану здоров’я та опікуватись навколишнім середовищем. Попит на органічні продукти харчування став одним з компонентних змін, які впливають на сучасну модель споживання. Дослідили чинники, що обмежують розвиток вітчизняного ринку органічних продуктів, серед яких найбільший вплив мають недостатнє інституційне забезпечення та рівень професійних знань і досвіду у даній сфері та високі торгові надбавка на органічні продукти харчування в торговельних мережах України. Основними каналами збуту органічної продукції залишаються точки продажу, інтернет/соціальні мережі, спеціалізовані статті, ярмарки та різні заходи, телереклама. Проаналізували традиційні маркетингові технології просування органічної продукції, що широко використовуються товаровиробниками. Найбільш популярними залишаються: особисті продажі, участь у вставках і ярмарках, інтернет-маркетинг, е-mail-розсилка, маркетинг у соціальних мережах, брендинг. Досліджуючи досвід найвідоміших вітчизняних органічних брендів, визначили нові маркетингові технології та інструменти, які використовувались на практиці цих компаній. До найбільш ефективних маркетингових технологій та комунікаційних інструментів, в умовах цифровізації, належить застосування підходу story-telling, який позитивно впливає на ставлення споживачів до бренда. Використання SEO-просування збільшить результативність пошуку за конкурентними ключовими словами та допоможе залучити потенційних споживачів на сайт і зробить його більш популярним серед них. Інфлюенс-маркетинг став повноцінним інструментом просування, який за кілька років перетворився з допоміжної маркетингового інструменту на індустрію. Менш популярним на вітчизняних теренах залишаться нормкор-маркетинг, який набирає швидких обертів в світі, особливо в сфері просування органічних продуктів. В умовах цифровізації керівникам органічного виробництва, також необхідно застосовувати нові маркетингові технології та підходи, які також допоможуть зацікавити та сформувати лояльність споживачів для досягнення стабільних конкурентних позицій на ринку.
Структура капіталу підприємства: теоретичні підходи та напрямки оптимізації в сучасних умовах
Authors: Didukh Serhii , Fedorova Tetiana
Published: January 2025

У статті представлено огляд теоретичних підходів до визначення категорії «капітал» й удосконалення структури капіталу підприємств. Початок повномасштабної війни в Україні у 2022 р. кардинальним чином змінив кон’юнктуру фінансового ринку, що потребує ефективного та оперативного адаптування політики управління структурою капіталу до нових умов. Оптимізація структури капіталу на основі використання ефекту фінансового левериджу в умовах війни ускладнене підвищенням вартості позикового капіталу, обмеженням доступу до фінансових ринків та суттєвим зниженням фінансових результатів українських підприємств, як це показано у статті. Окреслено актуальні напрямки оптимізації структури капіталу в сучасних умовах військового часу: зменшення частки позикового капіталу шляхом проведення переговорів із кредиторами, зменшення вартості позикового капіталу шляхом перекредитування, підвищення операційної рентабельності та підвищення ефективності управління дебіторською та кредиторською заборгованістю.