bluuebunny/crossref_metadata_2025 huggingface dataset:
Theranostic applications of optical coherence tomography in neurosurgery?
Authors: Hartmann Karl , Stein Klaus-Peter , Neyazi Belal , Sandalcioglu I. Erol
Published: August 2021

In light of our own experiences, we value the existing literature to critically point out possible “near” future applications of optical coherence tomography (OCT) as an intraoperative neurosurgical guidance tool. “Pub Med”, “Cochrane Library”, “Crossref Metadata Search”, and “IEEE Xplore” databases as well as the search engine “Google Scholar” were screened for “optical coherence tomography + neurosurgery”, “optical coherence tomography + intraoperative imaging + neurosurgery”, and “microscope integrated optical coherence tomography + neurosurgery”. n = 51 articles related to the use of OCT as an imaging technique in the field of neurosurgery or neurosurgical research. n = 7 articles documented the intraoperative use of OCT in patients. n = 4 articles documented the use of microscope-integrated optical coherence tomography as a neurosurgical guidance tool. The Results demonstrate that OCT is the first imaging technique to study microanatomy in vivo. Postoperative analysis of intraoperative scans holds promise to enrich our physiological and pathophysiological understanding of the human brain. No data exists to prove that OCT-guided surgery minimizes perioperative morbidity or extends tumor resection. But results suggest that regular use of microscope-integrated OCT could increase security during certain critical microsurgical steps like, e.g., dural dissection at cavernous sinus, transtentorial approaches, or aneurysm clip placement. Endoscopy integration could aid surgery in regions which are not yet accessible to real-time imaging modalities like the ventricles or hypophysis. Theranostic instruments which combine OCT with laser ablation might gain importance in the emerging field of minimal invasive tumor surgery. OCT depicts vessel wall layers and its pathologies uniquely. Doppler OCT could further visualize blood flow in parallel. These abilities shed light on promising future applications in the field of vascular neurosurgery.
Optimization and assessment of a sequential extraction procedure for calcium carbonate rocks
Authors: Scheplitz Janin , Koopmann Sarah , Fröllje Henning , Pichler Thomas
Published: August 2021

Sequential extraction analyses are widely used for the determination of element speciation in sediments and soils. Typical sequential extraction protocols were developed to extract from low-carbonate samples and therefore are not necessarily suitable for high-carbonate samples. In this study, we tested increased reagent to sample ratios to adjust an existing sequential extraction procedure to analyze high-CaCO3 samples with concentrations ranging from 70 to above 90 %. Complete dissolution of the CaCO3 phase, and a higher extraction efficiency of manganese associated with the carbonate phase, was achieved when using four times the original reagent to sample ratio in the 2nd extraction step. This increase of reagent did not compromise the extraction of subsequent phases as shown by unaffected Fe concentrations in a low-carbonate sample. Hence, an essential outcome was that increasing the solution to sample ratio did not lead to the dissolution of other sedimentary phases, such as hydrous and crystalline iron oxides or sulfides. Thus, compared to other extraction protocols that use a lower reagent to sample ratio in the carbonate dissolution step, the new protocol allowed the complete extraction of oxide and sulfide phases in the following extraction steps. Furthermore, the study demonstrated the benefit of replacing Na-acetate with NH4-acetate to extract exchangeable ions and carbonates. We observed increased intensities for several analytes, i.e., trace metals such as Mo and As, due to less suppression of the analyte signal by NH4-acetate than by Na-acetate during analysis by inductively coupled plasma optical emission spectrometry (ICP-OES).
Ignorance implicatures of modified numerals
Authors: Cremers Alexandre , Coppock Liz , Dotlačil Jakub , Roelofsen Floris
Published: August 2021

Modified numerals, such as at least three and more than five, are known to sometimes give rise to ignorance inferences. However, there is disagreement in the literature regarding the nature of these inferences, their context dependence, and differences between at least and more than. We present a series of experiments which sheds new light on these issues. Our results show that (a) the ignorance inferences of at least are more robust than those of more than, (b) the presence and strength of the ignorance inferences triggered by both at least and more than depends on the question under discussion (QUD), and (c) whether ignorance inferences are detected in a given experimental setting depends partly on the task that participants are asked to perform (e.g., an acceptability task versus an inference task). We offer an Optimality Theoretic account of these findings. In particular, the task effect is captured by assuming that in performing an acceptability task, participants take the speaker’s perspective in order to determine whether an expression is optimal given a certain epistemic state, while in performing an inference task they take the addressee’s perspective in order to determine what the most likely epistemic state of the speaker is given a certain expression. To execute the latter task in a fully rational manner, participants have to perform higher-order reasoning about alternative expressions the speaker could have used. Under the assumption that participants do not always perform such higher-order reasoning but also often resort to so-called unidirectional optimization, the task effect finds a natural explanation. This also allows us to relate our finding to asymmetries between comprehension and production that have been found in language acquisition.
Philosophers in research ethics committees—what do they think they’re doing? An empirical-ethical analysis
Authors: Gauckler Charlotte
Published: August 2021

Research ethics committees in Germany usually don’t have philosophers as members and if so, only contingently, not provided for by statute. This is interesting from a philosophical perspective, assuming that ethics is a discipline of philosophy. It prompts the question what role philosophers play in those committees they can be found in. Eight qualitative semi-structured interviews were conducted to explore the self-perception of philosophers regarding their contribution to research ethics committees. The results show that the participants generally don’t view themselves as ethics experts. They are rather unanimous on the competencies they think they contribute to the committee but not as to whether those are philosophical competencies or applied ethical ones. In some cases they don’t see a big difference between their role and the role of the jurist member. In the discussion section of this paper I bring up three topics, prompted by the interviews, that need to be addressed: (1) I argue that the interviewees’ unwillingness to call themselves ethics experts might have to do with a too narrow understanding ofethics expertise. (2) I argue that the disagreement among the interviewees concerning therelationship between moral philosophy and applied ethicsmight be explained on a theoretical or on a practical level. (3) I argue that there is some lack of clarity concerning therelationship between ethics and lawin research ethics committees and that further work needs to be done here. All three topics, I conclude, need further investigation.
Jeremy is a... Expressive-relativism and expressives in predicative positions
Authors: Berškytė Justina
Published: August 2021

Expressives are words that convey speakers’ attitudes towards a particular object or situation. Consider two examples:

Attributive: That f**khead Jeremy forgot the turkey.

Predicative: Jeremy is a f**khead.

In both examples the word f**khead communicates some expressive content - the negative attitude of the speaker. However, only in Predicative does it appear to contribute to the truth-conditional content. The task is to explain the semantics of the word f**khead when it seemingly behaves wildly differently in different syntactic positions. In this paper I consider several good candidates for dealing with f**khead occurring in Predicative position: Expressivist and Descriptive approaches that treat f**khead in Predicative as purely descriptive; and Expressive-Contextualism that treats Predicative as communicating to both expressive and descriptive dimensions. I show that none of the options fully capture the meaning of f**khead. Treating Predicative as purely descriptive leaves out the highly important expressive element, whilst Contextualist semantics does not seem as a suitable descriptive theory for expressives. I finally present a novel hybrid account that combines Expressivist semantics with Relativism. I call this view Expressive-Relativism. I show that by adopting Expressive-Relativism we can not only explain the relationship of f**khead in Attributive and Predicative, but also give a suitable descriptive theory that captures the truth-conditions of Predicative.
The impact of chemotherapy-induced inner ear damage on quality of life in cancer survivors: a qualitative study
Authors: Pearson Stephanie E. , Caimino Charlotte , Shabbir Maryam , Baguley David M.
Published: August 2021

Purpose

This study aimed to explore the burden of inner ear damage (ototoxicity) on adults living with and beyond cancer treated with chemotherapy and  the impact on their quality of life (QoL). Furthermore, this study aimed to explore patient awareness surrounding chemotherapy-induced inner ear damage, known as ototoxicity, and assess what support they had been offered.

Methods

Participants were adults who had undergone chemotherapy, recruited from cancer clinics, charities and social media. Using semi-structured interviews and fieldnotes, an inductive thematic analysis was used to develop key themes surrounding this topic.

Results

Twenty participants from the UK were interviewed. Two key themes were developed from the thematic analysis, cancer-related QoL and ototoxicity-related QoL, with each one including 5 subthemes. Subthemes consisted of impact of ototoxicity, hearing, tinnitus, clinical experience, audiological assessments, and impact of treatment, cancer and chemotherapy, other toxicities, information and patient reflections.

Conclusions

Ototoxicity can have a negative impact on QoL, specifically on social life and the fear of hearing loss and/or tinnitus worsening. There are opportunities for increased awareness by patients and clinicians, including improved information sources, and hearing monitoring not only for those undergoing platinum-based chemotherapy but many others surviving after treatment for cancer.

Implications for Cancer Survivors

Better monitoring of hearing and information about ototoxicity during chemotherapy could potentially reduce the fear of the symptoms of ototoxicity worsening. Furthermore, hearing monitoring would facilitate the detection of hearing loss at early stages of survivorship, which would facilitate earlier access to clinical interventions and longer term counselling.
Investigating spatio-temporal mobility patterns and changes in metro usage under the impact of COVID-19 using Taipei Metro smart card data
Authors: Mützel Christian Martin , Scheiner Joachim
Published: August 2021

Modern public transit systems are often run with automated fare collection (AFC) systems in combination with smart cards. These systems passively collect massive amounts of detailed spatio-temporal trip data, thus opening up new possibilities for public transit planning and management as well as providing new insights for urban planners. We use smart card trip data from Taipei, Taiwan, to perform an in-depth analysis of spatio-temporal station-to-station metro trip patterns for a whole week divided into several time slices. Based on simple linear regression and line graphs, days of the week and times of the day with similar temporal passenger flow patterns are identified. We visualize magnitudes of passenger flow based on actual geography. By comparing flows for January to March 2019 and for January to March 2020, we look at changes in metro trips under the impact of the coronavirus pandemic (COVID-19) that caused a state of emergency around the globe in 2020. Our results show that metro usage under the impact of COVID-19 has not declined uniformly, but instead is both spatially and temporally highly heterogeneous.
Construction of 1D Heterostructure NiCo@C/ZnO Nanorod with Enhanced Microwave Absorption
Authors: Wang Jianwei , Jia Zirui , Liu Xuehua , Dou Jinlei , Xu Binghui , Wang Bingbing , Wu Guanglei
Published: August 2021

Layered double hydroxides (LDHs) have a special structure and atom composition, which are expected to be an excellent electromagnetic wave (EMW) absorber. However, it is still a problem that obtaining excellent EMW-absorbing materials from LDHs. Herein, we designed heterostructure NiCo-LDHs@ZnO nanorod and then subsequent heat treating to derive NiCo@C/ZnO composites. Finally, with the synergy of excellent dielectric loss and magnetic loss, an outstanding absorption performance could be achieved with the reflection loss of − 60.97 dB at the matching thickness of 2.3 mm, and the widest absorption bandwidth of 6.08 GHz was realized at 2.0 mm. Moreover, this research work provides a reference for the development and utilization of LDHs materials in the field of microwave absorption materials and can also provide ideas for the design of layered structural absorbers.
Entropy-regularized 2-Wasserstein distance between Gaussian measures
Authors: Mallasto Anton , Gerolin Augusto , Minh Hà Quang
Published: August 2021

Gaussian distributions are plentiful in applications dealing in uncertainty quantification and diffusivity. They furthermore stand as important special cases for frameworks providing geometries for probability measures, as the resulting geometry on Gaussians is often expressible in closed-form under the frameworks. In this work, we study the Gaussian geometry under the entropy-regularized 2-Wasserstein distance, by providing closed-form solutions for the distance and interpolations between elements. Furthermore, we provide a fixed-point characterization of a population barycenter when restricted to the manifold of Gaussians, which allows computations through the fixed-point iteration algorithm. As a consequence, the results yield closed-form expressions for the 2-Sinkhorn divergence. As the geometries change by varying the regularization magnitude, we study the limiting cases of vanishing and infinite magnitudes, reconfirming well-known results on the limits of the Sinkhorn divergence. Finally, we illustrate the resulting geometries with a numerical study.
Associations between early thiamine administration and clinical outcomes in critically ill patients with acute kidney injury
Authors: Li Xunliang , Luan Hong , Zhang Hui , Li Chenyu , Bu Quandong , Zhou Bin , Tang Nina , Zhou Haiyan , Xu Yan , Jiang Wei , Zhao Long , Man Xiaofei , Che Lin , Wang Yanfei , Luo Congjuan , Sun Jianping
Published: August 2021

The effects of early thiamine use on clinical outcomes in critically ill patients with acute kidney injury (AKI) are unclear. The purpose of this study was to investigate the associations between early thiamine administration and clinical outcomes in critically ill patients with AKI. The data of critically ill patients with AKI within 48 h after ICU admission were extracted from the Medical Information Mart for Intensive Care III (MIMIC III) database. PSM was used to match patients early receiving thiamine treatment to those not early receiving thiamine treatment. The association between early thiamine use and in-hospital mortality due to AKI was determined using a logistic regression model. A total of 15 066 AKI patients were eligible for study inclusion. After propensity score matching (PSM), 734 pairs of patients who did and did not receive thiamine treatment in the early stage were established. Early thiamine use was associated with lower in-hospital mortality (OR 0·65; 95 % CI 0·49, 0·87; P < 0·001) and 90-d mortality (OR 0·58; 95 % CI 0·45, 0·74; P < 0·001), and it was also associated with the recovery of renal function (OR 1·26; 95 % CI 1·17, 1·36; P < 0·001). In the subgroup analysis, early thiamine administration was associated with lower in-hospital mortality in patients with stages 1 to 2 AKI. Early thiamine use was associated with improved short-term survival in critically ill patients with AKI. It was possible beneficial role in patients with stages 1 to 2 AKI according to the Kidney Disease: Improving Global Outcomes criteria.
Dietary acid load and mortality from all causes, CVD and cancer: results from the Golestan Cohort Study
Authors: Hejazi Ehsan , Emamat Hadi , Sharafkhah Maryam , Saidpour Atoosa , Poustchi Hossein , Sepanlou Sadaf , Sotoudeh Masoud , Dawsey Sanford , Boffetta Paolo , Abnet Christian C , Kamangar Farin , Etemadi Arash , Pourshams Akram , Malekshah Akbar Fazeltabar , Berennan Paul , Malekzadeh Reza , Hekmatdoost Azita
Published: August 2021

Given the limited studies and controversial results on association between dietary acid load and mortality from CVD and cancers, we aimed to investigate this association in a large population cohort study in Middle East, with a wide range of dietary acid load. The study was conducted on the platform of the Golestan Cohort Study (GCS), which enrolled 50 045 participants in 2004–2008. Dietary intake was assessed using a validated FFQ. Dietary potential renal acid load (PRAL) score was calculated from nutrient intake. Death and its causes were identified and confirmed by two or three physicians. Cox proportional hazards regression was used to estimate hazard ratio (HR) and 95 % CI for total and cause-specific mortalities. Then, the associations were modelled using restricted cubic splines. PRAL range was −57·36 to +53·81 mEq/d for men and −76·70 to +49·08 for women. During 555 142 person-years of follow-up, we documented 6830 deaths, including 3070 cardiovascular deaths, 1502 cancer deaths and 2258 deaths from other causes. For overall deaths, in final model after adjustment for confounders, participants in the first and fifth quintiles of PRAL had a higher risk of mortality compared with the second quintile of PRAL (HR: 1·08; 95 % CI1·01, 1·16 and HR: 1·07; 95 % CI 1·01, 1·15, respectively); Pfor trend < 0·05). Participants in the first and fifth quintiles of PRAL had a 12 % higher risk of CVD mortality compared with the Q2 of PRAL (HR: 1·12; 95 % CI 1·01–1·25 and HR: 1·12; 95 % CI 1·01, 1·26, respectively; Pfor trend < 0·05). We found that all-cause and CVD mortality rates were higher in the lowest and highest PRAL values, in an approximately U-shaped relation (P-values for the overall association and the non-linear association of energy-adjusted PRAL with total mortality were < 0·001 and < 0·001, and with CVD mortality were 0·008 and 0·003, respectively). Our results highlight unfavourable associations of high acidity and alkalinity of diet with the increased total and CVD mortality risk. It may be important to consider a balanced acid–base diet as a protective strategy to prevent pre-mature death, especially from CVD.
Motivations and attitudes of Brazilian dairy farmers regarding the use of automated behaviour recording and analysis systems
Authors: Vieira Aline C. , Fischer Vivian , Canozzi Maria Eugênia A. , Garcia Lisiane S. , Morales-Piñeyrúa Jessica Tatiana
Published: August 2021

In this Research Communication we investigate the motivations of Brazilian dairy farmers to adopt automated behaviour recording and analysis systems (ABRS) and their attitudes towards the alerts that are issued. Thirty-eight farmers participated in the study distributed into two groups, ABRS users (USERS, n = 16) and non-users (NON-USERS, n = 22). In the USERS group 16 farmers accepted being interviewed, answering a semi-structured interview conducted by telephone, and the answers were transcribed and codified. In the NON-USERS group, 22 farmers answered an online questionnaire. Descriptive analysis was applied to coded answers. Most farmers were young individuals under 40 years of age, with undergraduate or graduate degrees and having recently started their productive activities, after a family succession process. Herd size varied with an overall average of approximately 100 cows. Oestrus detection and cow's health monitoring were the main reasons given to invest in this technology, and cost was the most important factor that prevented farmers from purchasing ABRS. All farmers in USERS affirmed that they observed the target cows after receiving a health or an oestrus alert. Farmers believed that they were able to intervene in the evolution of the animals' health status, as the alerts gave a window of three to four days before the onset of clinical signs of diseases, anticipating the start of the treatment.The alerts issued by the monitoring systems helped farmers to reduce the number of cows to be observed and to identify pre-clinically sick and oestrous animals more easily. Difficulties in illness detection and lack of definite protocols impaired the decision making process and early treatment, albeit farmers believed ABRS improved the farm's routine and reproductive rates.
Koopman wavefunctions and Clebsch variables in Vlasov–Maxwell kinetic theory
Authors: Tronci Cesare , Joseph Ilon
Published: August 2021

Motivated by recent discussions on the possible role of quantum computation in plasma simulations, here, we present different approaches to Koopman's Hilbert-space formulation of classical mechanics in the context of Vlasov–Maxwell kinetic theory. The celebrated Koopman–von Neumann construction is provided with two different Hamiltonian structures: one is canonical and recovers the usual Clebsch representation of the Vlasov density, the other is non-canonical and appears to overcome certain issues emerging in the canonical formalism. Furthermore, the canonical structure is restored for a variant of the Koopman–von Neumann construction that carries a different phase dynamics. Going back to van Hove's prequantum theory, the corresponding Koopman–van Hove equation provides an alternative Clebsch representation which is then coupled to the electromagnetic fields. Finally, the role of gauge transformations in the new context is discussed in detail.
Promoting health economic evaluation studies in the AYUSH system of medicine: the need of the hour
Authors: Muthappan Sendhilkumar , Bagepally Bhavani Shankara , Ponnaiah Manickam
Published: August 2021

The double burden of communicable and noncommunicable diseases is a major threat to the Indian public health system. AYUSH, an acronym for Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa-Rigpa, and Homeopathy, represents the Indian system of medicine recognized by the Government of India. Mainstreaming of AYUSH is one of the key strategies of the Indian government for tackling increasing disease burden through initiatives such as AYUSH wellness centers, telemedicine, and quality control measures for medications in the AYUSH system of medicine. Such investment of resources in health systems may require economic evaluations. However, such evaluations are lacking in the AYUSH system, except for a few in homeopathy and yoga. In the absence of evidence from economic evaluations, researchers and decision makers are guided mostly by clinical efficacy while formulating healthcare strategies. In view of the increasing use of AYUSH across the country, economic evaluations of the AYUSH system are the need of the hour to aid healthcare decision making.
An improved primal-dual approximation algorithm for the k-means problem with penalties
Authors: Ren Chunying , Xu Dachuan , Du Donglei , Li Min
Published: August 2021

In the k-means problem with penalties, we are given a data set $${\cal D} \subseteq \mathbb{R}^\ell $$ of n points where each point $$j \in {\cal D}$$ is associated with a penalty cost pj and an integer k. The goal is to choose a set $${\rm{C}}S \subseteq {{\cal R}^\ell }$$ with |CS| ≤ k and a penalized subset $${{\cal D}_p} \subseteq {\cal D}$$ to minimize the sum of the total squared distance from the points in D / Dp to CS and the total penalty cost of points in Dp, namely $$\sum\nolimits_{j \in {\cal D}\backslash {{\cal D}_p}} {d^2}(j,{\rm{C}}S) + \sum\nolimits_{j \in {{\cal D}_p}} {p_j}$$. We employ the primal-dual technique to give a pseudo-polynomial time algorithm with an approximation ratio of (6.357+ε) for the k-means problem with penalties, improving the previous best approximation ratio 19.849+∊ for this problem given by Feng et al. in Proceedings of FAW (2019).
Combining patient-specific, digital 3D models with tele-education for adolescents with CHD
Authors: Liddle David , Balsara Sheri , Hamann Karin , Christopher Adam , Olivieri Laura , Loke Yue-Hin
Published: August 2021

Introduction:

Adolescents with CHD require transition to specialised adult-centred care. Previous studies have shown that adolescents’ knowledge of their medical condition is correlated with transition readiness. Three-dimensional printed models of CHD have been used to educate medical trainees and patients, although no studies have focused on adolescents with CHD. This study investigates the feasibility of combining patient-specific, digital 3D heart models with tele-education interventions to improve the medical knowledge of adolescents with CHD.

Methods:

Adolescent patients with CHD, aged between 13 and 18 years old, were enrolled and scheduled for a tele-education session. Patient-specific digital 3D heart models were created using images from clinically indicated cardiac magnetic resonance studies. The tele-education session was performed using commercially available, web-conferencing software (Zoom, Zoom Video Communications Inc.) and a customised software (Cardiac Review 3D, Indicated Inc.) incorporating an interactive display of the digital 3D heart model. Medical knowledge was assessed using pre- and post-session questionnaires that were scored by independent reviewers.

Results:

Twenty-two adolescents completed the study. The average age of patients was 16 years old (standard deviation 1.5 years) and 56% of patients identified as female. Patients had a variety of cardiac defects, including tetralogy of Fallot, transposition of great arteries, and coarctation of aorta. Post-intervention, adolescents’ medical knowledge of their cardiac defects and cardiac surgeries improved compared to pre-intervention (p < 0.01).

Conclusions:

Combining patient-specific, digital 3D heart models with tele-education sessions can improve adolescents’ medical knowledge and may assist with transition to adult-centred care.
Upstream and downstream explanations of the harms of ultra-processed foods in national dietary guidelines
Authors: Quinn Madalyn , Jordan Helen , Lacy-Nichols Jennifer
Published: August 2021

Objective:

Dietary advice about the potential health risks of unhealthy foods or diets has historically been communicated in terms of nutrients. Recent evidence has shown that the processing of food itself is independently attributable to harmful outcomes, particularly a new category of foods described to be ‘ultra-processed’. Dietary guidelines (DG) are a key policy tool to translate and communicate nutrition research; however, there is little research exploring whether and how the harms of food processing are communicated and rationalised in dietary advice.

Design:

Nineteen publicly available DG were thematically analysed to explore: (1) the diversity of terms used to refer to processed foods and (2) the underlying explanations and rationales provided to reduce consumption of processed foods.

Setting:

International.

Participants:

Sample of national dietary guidelines.

Results:

Seventeen different descriptive terms were used to refer to processed foods, with many countries using a large variation of terms within their DG. Six rationales to reduce consumption of processed foods were identified, which were grouped into four overarching domains: harmful outcomes (disease risk, environmental risk); food quality (food quality, nutrient content); diet quality and food environment.

Conclusion:

The rationales provided to reduce the consumption of processed foods reflect upstream and downstream determinants of health. However, the persistence of nutrient-based rationales indicate that most DG do not apply an upstream understanding of the issues with ultra-processing. Further, the diversity of terms and foods referenced in DG suggest that the concept of ultra-processing is subject to multiple interpretations.
Henry Allison on Kant’s First Analogy
Authors: Osborne Gregg
Published: August 2021

Henry Allison’s interpretation of Kant’s First Analogy is among the most intriguing in the literature. Its virtues are considerable, but no previous discussion has done full justice to them. Nor has any previous discussion systematically explored the most important challenges to which it seems subject. This paper does both. Early sections provide a more thorough exegesis than is otherwise available and provide stronger textual backing than does Allison himself. Later sections turn to problems, most of which have not been raised by others. These problems, while serious, do not necessarily rule out the interpretation of Allison.
Multiband antenna design based on Gosper fractal for implantable biomedical devices
Authors: Kumar Rajeev , Singh Surinder , Singh Chauhan Ajay pal
Published: August 2021

In this paper, a novel multiband implantable planar inverted-F antenna (PIFA) antenna based on Gosper curve fractal geometry is designed for biomedical telemetry applications. The antenna has covered four dedicated frequency bands; medical implant communication system band (MICS 402–405 MHz), industrial, scientific, and medical bands (ISM 902–928 MHz and 2.4–2.5 GHz), and wireless medical telemetry services (WMTS 1395–1400 and 1429–1432 MHz). The proposed antenna is designed on Rogers RO 3010 substrate of thickness 25 mil and volume equal to 153.67 mm3. The reflection coefficient and the radiation pattern are measured inside muscle-mimicking liquid tissue phantom. The antenna has achieved the impedance bandwidth of 126, 406, 168, and 175 MHz at MICS (403 MHz), ISM (915 MHz), WMTS (1400 MHz), and ISM (2.45 GHz) with maximum gain value −33.6, −21.04, −15.48, and −10.25 dBi, respectively. The data link range between the implantable antenna and off body antenna has been performed with −16 dBm input power. Additionally, the obtained specific absorption rate with the input of 25 μW power has also been obtained within the safety limit and hence ensures the reliability of the proposed antenna.
Liquid Containing Clouds at the North Slope of Alaska Demonstrate Sensitivity to Local Industrial Aerosol Emissions
Authors: Maahn Maximilian , Goren Tom , Shupe Matthew D. , de Boer Gijs
Published: August 2021

Cloud condensation nucleus control alter cloud solar albedo through cloud droplet size. Here, we leverage anthropogenic emissions at the North Slope of Alaska as a natural laboratory to study relationships between aerosols and Arctic liquid‐containing clouds. Averaging 14 years of MODIS observations, we found a reduction in temporally averaged cloud effective radius () of up to 1.0 μm related to localized pollution. Pronounced regional gradients in cloud frequency of occurrence and liquid water path prohibit the detection of potential changes of these variables. Observed changes of alter radiative fluxes and increase cloud‐reflected shortwave radiation by up to 0.8 W m−2 in the Prudhoe Bay area for the period covered by observations (April–September). Due to the frequent occurrence of liquid‐containing clouds, this implies that enhanced local emissions in Arctic regions can impact climate processes.
Receiver Function Imaging of the Amphibious NE Japan Subduction Zone—Effects of Low‐Velocity Sediment Layer
Authors: Kim HyeJeong , Kawakatsu Hitoshi , Akuhara Takeshi , Shinohara Masanao , Shiobara Hajime , Sugioka Hiroko , Takagi Ryota
Published: August 2021

This study presents reflectivity images of the northeast (NE) Japan subduction zone continuous across the ocean and land. As nearly half of its forearc region is under the ocean, data from ocean bottom seismometers (OBSs) must be utilized to fully image the region by passive seismic analysis. The use of OBS data has been a challenge due to inherent characters of the ocean bottom observations: high noise level and effects of seafloor sediment. Now, decent imaging is possible in NE Japan overcoming the high level noise due to the accumulated data set of the OBSs. The low‐velocity of seafloor sediment significantly delays and amplifies S waves passing through them, and thus complicates teleseismic waveforms. We identify and correct these effects to produce coherent receiver function images throughout the amphibious subduction zone. Our images provide a potential for discussing new structural features and will help better understanding of the dynamics of the NE Japan subduction zone.
Melatonin as an immunomodulator in children with Down syndrome
Authors: Huggard Dean , Kelly Lynne , Worrall Amy , Gallagher Eleanor , Fallah Lida , Yoo Lucas Lu , McGrane Fiona , Lagan Niamh , Roche Edna , Balfe Joanne , Doherty Derek G. , Molloy Eleanor J.
Published: August 2021

Background

Down syndrome (DS) is a disorder characterised by marked immune dysfunction, increased mortality from sepsis, chronic inflammation, increased oxidative stress, sleep disturbance and possibly abnormal endogenous melatonin levels. Melatonin has a myriad of immune functions, and we hypothesised that this therapeutic agent could modulate the innate immune system in this cohort.

Methods

We investigated neutrophil and monocyte function (CD11b, TLR4 expression by flow cytometry), genes involved in TLR signalling (MyD88, IRAK4, TRIF), the inflammasome (NLRP3, IL-1β), and circadian rhythm (BMAL, CLOCK, CRY) by qPCR, and inflammatory cytokines (IL-2, IL-6, IL-8, IL-18, IL-1β, TNF-α, IFN-γ, IL-10, IL-1ra, VEGF, Epo, GM-CSF) by enzyme-linked immunosorbent assay (ELISA) following immunomodulation with LPS endotoxin and melatonin. 47 children with DS and 23 age- and sex-matched controls were recruited.

Results

We demonstrated that melatonin has several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signalling, genes involved in the inflammasome and has the potential to reduce LPS-induced inflammatory responses.

Conclusions

Immunomodulatory effects of melatonin were found in both paediatric cohorts with more marked effects in the children with DS. Melatonin mediates immune response through a wide array of mechanisms and this immunomodulator may buffer the inflammatory response by regulating pro and anti-inflammatory signalling.

Impact

We highlight that melatonin mediates its immune response through a wide array of mechanisms, its effects appear to be dose dependant and children with Down syndrome may be more receptive to treatment with it.

Immunomodulatory effects of melatonin were demonstrated with marked effects in the children with Down syndrome with a reduction of MyD88, IL-1ß and NLRP3 expression in whole-blood samples.

Melatonin is a proposed anti-inflammatory agent with a well-established safety profile, that has the potential for mitigation of pro- and anti-inflammatory cytokines in paediatric Down syndrome cohorts, though further clinical trials are warranted.
Directed synthesis of a hybrid improper magnetoelectric multiferroic material
Authors: Zhu Tong , Orlandi Fabio , Manuel Pascal , Gibbs Alexandra S. , Zhang Weiguo , Halasyamani P. Shiv. , Hayward Michael A.
Published: August 2021

Preparing materials which simultaneously exhibit spontaneous magnetic and electrical polarisations is challenging as the electronic features which are typically used to stabilise each of these two polarisations in materials are contradictory. Here we show that by performing low-temperature cation-exchange reactions on a hybrid improper ferroelectric material, Li2SrTa2O7, which adopts a polar structure due to a cooperative tilting of its constituent TaO6octahedra rather than an electronically driven atom displacement, a paramagnetic polar phase, MnSrTa2O7, can be prepared. On cooling below 43 K the Mn2+centres in MnSrTa2O7adopt a canted antiferromagnetic state, with a small spontaneous magnetic moment. On further cooling to 38 K there is a further transition in which the size of the ferromagnetic moment increases coincident with a decrease in magnitude of the polar distortion, consistent with a coupling between the two polarisations.
Linear reinforcement learning in planning, grid fields, and cognitive control
Authors: Piray Payam , Daw Nathaniel D.
Published: August 2021

It is thought that the brain’s judicious reuse of previous computation underlies our ability to plan flexibly, but also that inappropriate reuse gives rise to inflexibilities like habits and compulsion. Yet we lack a complete, realistic account of either. Building on control engineering, here we introduce a model for decision making in the brain that reuses a temporally abstracted map of future events to enable biologically-realistic, flexible choice at the expense of specific, quantifiable biases. It replaces the classic nonlinear, model-based optimization with a linear approximation that softly maximizes around (and is weakly biased toward) a default policy. This solution demonstrates connections between seemingly disparate phenomena across behavioral neuroscience, notably flexible replanning with biases and cognitive control. It also provides insight into how the brain can represent maps of long-distance contingencies stably and componentially, as in entorhinal response fields, and exploit them to guide choice even under changing goals.
Pre-meiotic 21-nucleotide reproductive phasiRNAs emerged in seed plants and diversified in flowering plants
Authors: Pokhrel Suresh , Huang Kun , Bélanger Sébastien , Zhan Junpeng , Caplan Jeffrey L. , Kramer Elena M. , Meyers Blake C.
Published: August 2021

Plant small RNAs are important regulatory elements that fine-tune gene expression and maintain genome integrity by silencing transposons. Reproductive organs of monocots produce abundant phased, small interfering RNAs (phasiRNAs). The 21-nt reproductive phasiRNAs triggered by miR2118 are highly enriched in pre-meiotic anthers, and have been found in multiple eudicot species, in contrast with prior reports of monocot specificity. The 24-nt reproductive phasiRNAs are triggered by miR2275, and are highly enriched during meiosis in many angiosperms. Here, we report the widespread presence of the 21-nt reproductive phasiRNA pathway in eudicots including canonical and non-canonical microRNA (miRNA) triggers of this pathway. In eudicots, these 21-nt phasiRNAs are enriched in pre-meiotic stages, a spatiotemporal distribution consistent with that of monocots and suggesting a role in anther development. Although this pathway is apparently absent in well-studied eudicot families including the Brassicaceae, Solanaceae and Fabaceae, our work in eudicots supports an earlier singular finding in spruce, a gymnosperm, indicating that the pathway of 21-nt reproductive phasiRNAs emerged in seed plants and was lost in some lineages.
Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
Authors: Vigneault Patrick , Parent Sandrine , Kanda Pushpinder , Michie Connor , Davis Darryl R. , Nattel Stanley
Published: August 2021

We have shown that calcium-activated potassium (KCa)-channels regulate fundamental progenitor-cell functions, including proliferation, but their contribution to cell-therapy effectiveness is unknown. Here, we test the participation of KCa-channels in human heart explant-derived cell (EDC) physiology and therapeutic potential. TRAM34-sensitive KCa3.1-channels, encoded by theKCNN4gene, are exclusively expressed in therapeutically bioactive EDC subfractions and maintain a strongly polarized resting potential; whereas therapeutically inert EDCs lack KCa3.1 channels and exhibit depolarized resting potentials. Somatic gene transfer ofKCNN4results in membrane hyperpolarization and increases intracellular [Ca2+], which boosts cell-proliferation and the production of pro-healing cytokines/nanoparticles. Intramyocardial injection of EDCs afterKCNN4-gene overexpression markedly increases the salutary effects of EDCs on cardiac function, viable myocardium and peri-infarct neovascularization in a well-established murine model of ischemic cardiomyopathy. Thus, electrophysiological engineering provides a potentially valuable strategy to improve the therapeutic value of progenitor cells for cardioprotection and possibly other indications.
Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana
Authors: Hachiya Takushi , Inaba Jun , Wakazaki Mayumi , Sato Mayuko , Toyooka Kiminori , Miyagi Atsuko , Kawai-Yamada Maki , Sugiura Daisuke , Nakagawa Tsuyoshi , Kiba Takatoshi , Gojon Alain , Sakakibara Hitoshi
Published: August 2021

Plants use nitrate, ammonium, and organic nitrogen in the soil as nitrogen sources. Since the elevated CO2 environment predicted for the near future will reduce nitrate utilization by C3 species, ammonium is attracting great interest. However, abundant ammonium nutrition impairs growth, i.e., ammonium toxicity, the primary cause of which remains to be determined. Here, we show that ammonium assimilation by GLUTAMINE SYNTHETASE 2 (GLN2) localized in the plastid rather than ammonium accumulation is a primary cause for toxicity, which challenges the textbook knowledge. With exposure to toxic levels of ammonium, the shoot GLN2 reaction produced an abundance of protons within cells, thereby elevating shoot acidity and stimulating expression of acidic stress-responsive genes. Application of an alkaline ammonia solution to the ammonium medium efficiently alleviated the ammonium toxicity with a concomitant reduction in shoot acidity. Consequently, we conclude that a primary cause of ammonium toxicity is acidic stress.
Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization
Authors: Agnew Christopher , Ayaz Pelin , Kashima Risa , Loving Hanna S. , Ghatpande Prajakta , Kung Jennifer E. , Underbakke Eric S. , Shan Yibing , Shaw David E. , Hata Akiko , Jura Natalia
Published: August 2021

Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. The link between receptor tetramerization and the mechanism of kinase activation, however, has not been elucidated. Here, using hydrogen deuterium exchange mass spectrometry (HDX-MS), small angle X-ray scattering (SAXS) and molecular dynamics (MD) simulations, combined with analysis of SMAD signaling, we show that the kinase domain of the type I receptor ALK2 and type II receptor BMPR2 form a heterodimeric complex via their C-terminal lobes. Formation of this dimer is essential for ligand-induced receptor signaling and is targeted by mutations in BMPR2 in patients with pulmonary arterial hypertension (PAH). We further show that the type I/type II kinase domain heterodimer serves as the scaffold for assembly of the active tetrameric receptor complexes to enable phosphorylation of the GS domain and activation of SMADs.
The effect of particle shape on the deformation and stress reduction of a gravel soil due to wetting
Authors: Mahinroosta Reza , Oshtaghi Vahid
Published: August 2021

This paper investigates the effect of particle shape on the stress reduction and collapse deformation of gravelly soil using a medium-scale direct shear test apparatus under different relative densities, normal stress, and shear stress levels. A new method based on the Micro-Deval test was introduced to produce sub-angular particles from angular particles. Therefore, two series of soil specimens were obtained with the same rock origin, particle size distribution, and relative density but different particle shapes. In addition to traditional direct shear tests on dry and wet specimens, a specific test procedure was applied to explore the stress reduction and collapse of soil specimens due to wetting. The results of the tests, including shear stress–shear displacement and vertical displacement-shear displacement, were compared. The results showed that the stress reduction and settlement due to wetting increased with vertical and shear stress levels in both types of particle shapes, with higher values in angular particle shapes. The particle breakage of the soil specimens was also studied quantitatively using the change in the particle size distribution before and after the test. It was shown that the wetting of the samples had more impact on the particle breakage in angular gravel than sub-angular gravel, which increased linearly with the normal stress.
Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients
Authors: Rumiz Eva , Cubillos Andrés , Vilar Juan Vicente , García Pilar , Berenguer Alberto , Fácila Lorenzo , Valero Ernesto , Vidal Verónica , Morell Salvador , Nuñez Julio
Published: August 2021

Pulmonary vascular resistance (PVR) is a marker of pulmonary vascular remodeling. A non-invasive model assessed by cardiovascular magnetic resonance (CMR) has been proposed to estimate PVR. However, its accuracy has not yet been evaluated in patients with heart failure. We prospectively included 108 patients admitted with acute heart failure (AHF), in whom a right heart catheterization (RHC) and CMR were performed at the same day. PVR was estimated by CMR applying the model: PVR = 19.38 − [4.62 × Ln pulmonary artery average velocity (in cm/s)] − [0.08 × right ventricle ejection fraction (in %)], and by RHC using standard formulae. The median age of the cohort was 67 years (interquartile range 58–73), and 34% were females. The median of PVR assessed by RHC and CMR were 2.2 WU (1.5–4) and 5 WU (3.4–7), respectively. We found a weak correlation between invasive PVR and PVR assessed by CMR (Spearman r = 0.21, p = 0.02). The area under the ROC curve for PVR assessed by CMR to detect PVR ≥ 3 WU was 0.57, 95% confidence interval (CI): 0.47–0.68. In patients with AHF, the non-invasive estimation of PVR using CMR shows poor accuracy, as well as a limited capacity to discriminate increased PVR values.