bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychometric properties of the Spanish version of the Weight Self-Stigma Questionnaire (S-WSSQ) in a sample of participants with obesity seeking weight loss treatment
Authors: Magallares Alejandro , de Valle Pilar Benito , Irles José Antonio , Recio Patricia , Jáuregui-Lobera Ignacio
Published: November 2022

Purpose

Weight self-stigma may be defined as a self-devaluation due to one’s identification with the group of people with obesity. The Weight Self-Stigma Questionnaire (WSSQ) is an instrument specifically designed to measure weight self-stigma in populations with overweight or obesity. The objective of this study was to adapt the WSSQ to the Spanish population (S-WSSQ) following the guidelines for cross-cultural adaptations.

Methods

The sample comprised 165 participants with obesity seeking weight loss treatment (65% women) at the “Hospital de Valme” (Seville, Spain). Scales to measure life satisfaction, self-esteem, positive and negative affect, and antifat attitudes were used to analyze the convergent and divergent validity of the S-WSSQ.

Results

A confirmatory factor analysis showed adequate values of the goodness of fit indexes of a two-factor model (χ2/df = 2.01 CFI = 0.92, IFI = 0.92, SRMR = 0.08, RMSEA = 0.078), replicating the structure found by the original authors. Cronbach’s alphas of the two factors were 0.76 (self-devaluation) and 0.77 (fear of enacted stigma). Composite Reliability values were 0.72 (self-devaluation) and 0.76 (fear of enacted stigma). Self-devaluation and fear of enacted stigma were negatively related to self-esteem, and positive affect, and positively related to negative affect and antifat attitudes. Finally, life satisfaction was negatively correlated to fear of enacted stigma.

Conclusions

Based on these results, it is concluded that the S-WSSQ has good psychometric properties and might be used by the Spanish-speaking scientific community to measure weight self-stigma.

Level of evidence

Level V, descriptive study.
Application of long-reach directional drilling boreholes for gas drainage of adjacent seams in coal mines with severe geological conditions
Authors: Leśniak Grzegorz , Brunner Daniel J. , Topór Tomasz , Słota-Valim Małgorzata , Cicha-Szot Renata , Jura Bartłomiej , Skiba Jacek , Przystolik Arnold , Lyddall Ben , Plonka Grzegorz
Published: November 2022

This study aimed to demonstrate the application of Long Reach Directionally Drilled Boreholes (LRDD) for gas drainage of adjacent seams before and during the longwall face operations of low permeability-high gas content coals Staszic-Wujek Hard Coal Mine in the Upper Silesia Coal Basin (Poland). Five LRDD Boreholes (TM1a-TM5) with a length of 300 and 400 m were located over coal seam 501 in the fractured zone and monitored over six months of longwall face operations. LRDD Boreholes were combined with Cross-Measured Boreholes. Reservoir characterization and geological modeling supported the results obtained from gas drainage. The drainage efficiency of LRDD Boreholes was the approximately 70% level, while conventional Cross-Measured Boreholes were only 30%. The highest goaf gas quality (94% methane concentration) was reported for TM4, placed at an average elevation of 41 m above coal seam 501. The highest goaf gas production (average 6.2 m3/min) was reported for LRDD Borehole TM3. This borehole was placed within the fracture zone (average elevation of 24.4 m) and drilled through the sandstone lithotype with the best reservoir properties, enhancing drainage performance. LRDD Boreholes TM2 and TM4 achieved similar performance. These three LRDD Boreholes were drilled close to the maximum principal horizontal stress direction, providing borehole stability during under-mining. The lowest goaf gas production was reported for LRDD Boreholes TM1a and TM5. Both Boreholes were placed in the rubble zone.
The Prevalence of High-Risk Behavior Among Adolescents in Aftercare Services and Transitioning from Out-of-home Care: A Systematic Review
Authors: Petäjä Ulla-Kaarina , Terkamo-Moisio Anja , Karki Suyen , Häggman-Laitila Arja
Published: November 2022

Adolescents in aftercare services who are transitioning from out-of-home care, also called care leavers, face more challenges in their lives, and engage in more risk behaviors, than their peers. However, no previous reviews have comprehensively addressed this issue to identify future research needs. The aim of this systematic review was to gather, assess, and synthesize previous studies concerning care leavers’ high-risk behavior. The search was conducted in six databases, with sixteen articles included in the final review. The selected research highlighted five forms of high-risk behavior: substance abuse, delinquency, sexual behavior, irresponsible use of money, and self-destructive behavior. The incidence of high-risk behavior among care leavers varied noticeably between the studies. Some of the studies reported significant connections between high-risk behavior and gender, race, reason(s) for placement, and the form and number of placements. The synthesized findings revealed a fragmented, limited view of care leavers’ high-risk behavior that highlighted substance abuse and delinquency. The development of adolescents, particularly care leavers, includes multiple factors that have either a conducive or protecting effect for high-risk behavior. Comprehensive research regarding care leavers’ high-risk behavior, including the associated factors, is needed to better support healthy development and success in transitioning to independent living.
Glass up-casting: a review on the current challenges in glass recycling and a novel approach for recycling “as-is” glass waste into volumetric glass components
Authors: Bristogianni Telesilla , Oikonomopoulou Faidra
Published: November 2022

This paper presents the casting of volumetric glass components from glass waste as an alternative glass-recycling approach. The approach is characterized by its flexibility to accommodate a variety of compositions and ability to yield volumetric (solid or thick-walled) glass products that can tolerate higher contamination rates without a significant compromise to their properties. The novelty of the proposed glass-to-glass recycling method lies in the “as-received” recycling of glass waste, using relatively low forming temperatures (750–1200 °C). This reduces both the need for expensive, labour-intensive and logistically complex purifying, segregation and treatment (e.g. removal of coatings) techniques, and the required energy and CO2emissions for product forming. Aim of this paper is to provide an overview of the potential but also of the technical and supply-chain challenges and limitations that still need to be tackled, in order to introduce this recycling approach to the market. Addressing the supply-chain barriers of glass recycling, the principal challenges linked to the collection and separation of glass waste and the established quality standards for the prevailing glass production technologies are identified, in order to argue upon the potential of this new recycling approach. In continuation, addressing the technical challenges that are mainly linked to contamination, an overview is provided of the main experimental findings on the influence of cullet contaminants and casting parameters on the generation of defects, and how these affect the mechanical properties. The experiments study a broad variety of glass compositions, including soda-lime, borosilicate, aluminosilicate and lead/barium glasses, and different levels of cullet contamination, of embedded (e.g. frit, wire) or external (e.g. stones, glass ceramics) character. Based on the cullet characteristics and imposed firing schedules, different glass quality grades arise and critical defects are highlighted. Thereafter, the most promising glass waste sources that can be recycled via this novel recycling approach are distinguished and directions for future research are highlighted.
Reinvigorating Country as teacher in Australian schooling: beginning with school teacher’s direct experiences, ‘relating with Country’
Authors: Spillman David , Wilson Ben , Nixon Monty , McKinnon Katharine
Published: November 2022

The Country as Teacher research project was a formative exploration of how Indigenous pedagogies might be taken-up as part of mainstream schooling for all Australian students. This paper reports on the first phase where participant teachers were guided and supported, through professional learning, to initiate their own ‘relating with Country’ practice. A Country as teacher pedagogy is enacted through cultivating the practice of reciprocal ‘relating with Country’, resulting in gratitude and learning about, from and how to care for the places we live. Enacting Country as Teacher in school-based curriculum operates as a ‘critical pedagogy of place’, contesting Eurocentric epistemic power in Australian curriculum, to provide a balanced ‘both ways’ education for all. We argue that for teachers to be able to appropriately facilitate Country as teacher pedagogies with students, they must first cultivate their own practice of ‘relating with Country’. In this paper, we examine the stories of 26 teachers in Canberra public schools as they develop their practice of relating with Country. These stories highlight the process, and participant’s challenges and successes. This paper contributes to foundational knowledge and experience for the uptake of Country as teacher pedagogies in Australian schools. Our emerging findings suggest that the practice of ‘relating with Country’ is within the reach of all teachers.
Seeing Color in Classical Art
Authors: Stager Jennifer M. S.
Published: November 2022

The remains of ancient Mediterranean art and architecture that have survived over the centuries present the modern viewer with images of white, the color of the stone often used for sculpture. Antiquarian debates and recent scholarship, however, have challenged this aspect of ancient sculpture. There is now a consensus that sculpture produced in the ancient Mediterranean world, as well as art objects in other media, were, in fact, polychromatic. Color has consequently become one of the most important issues in the study of classical art. Jennifer Stager's landmark book makes a vital contribution to this discussion. Analyzing the dyes, pigments, stones, earth, and metals found in ancient art works, along with the language that writers in antiquity used to describe color, she examines the traces of color in a variety of media. Stager also discusses the significance of a reception history that has emphasized whiteness, revealing how ancient artistic practice and ancient philosophies of color significantly influenced one another.
Token Forces
Authors: Coleman Katharina P. , Li Xiaojun
Published: November 2022

Token forces – tiny national troop contributions in much larger coalitions – have become ubiquitous in UN peacekeeping. This Element examines how and why this contribution type has become the most common form of participation in UN peace operations despite its limited relevance for missions' operational success. It conceptualizes token forces as a path-dependent unintended consequence of the norm of multilateralism in international uses of military force. The norm extends states' participation options by giving coalition builders an incentive to accept token forces; UN-specific types of token forces emerged as states learned about this option and secretariat officials adapted to state demand for it. The Element documents the growing incidence of token forces in UN peacekeeping, identifies the factors disposing states to contribute token forces, and discusses how UN officials channel token participation. The Element contributes to the literatures on UN peacekeeping, military coalitions, and the impacts of norms in international organizations.
Exponential Families in Theory and Practice
Authors: Efron Bradley
Published: November 2022

During the past half-century, exponential families have attained a position at the center of parametric statistical inference. Theoretical advances have been matched, and more than matched, in the world of applications, where logistic regression by itself has become the go-to methodology in medical statistics, computer-based prediction algorithms, and the social sciences. This book is based on a one-semester graduate course for first year Ph.D. and advanced master's students. After presenting the basic structure of univariate and multivariate exponential families, their application to generalized linear models including logistic and Poisson regression is described in detail, emphasizing geometrical ideas, computational practice, and the analogy with ordinary linear regression. Connections are made with a variety of current statistical methodologies: missing data, survival analysis and proportional hazards, false discovery rates, bootstrapping, and empirical Bayes analysis. The book connects exponential family theory with its applications in a way that doesn't require advanced mathematical preparation.
Historical development of the coaxial contra-rotating propeller
Authors: Filippone A.
Published: November 2022

We review the development of the contra-rotating propellers from the origins to the present. Initially, these systems were proposed to increase speed, then to increase propulsive efficiency, and thus reduce fuel burn. Ultimately, they hit another environmental limit: too much noise. Acoustics has been in fact the main focus of the development in the past 30 years. Pioneering work done across countries demonstrated several unique features of this propulsor. Various embodiments are available, namely contra-rotating, counter-rotating, co-axial, tandem, open rotor and prop-fans, collectively named contra-rotating propellers. This review only considers concepts that have been applied to real aircraft, prototypes that are known to have been flight tested (about 70 vehicles), or representative laboratory models. Five classifications are proposed: pioneers (before 1940), golden years (1940–1950), Western airplanes (1950s onwards), Soviet-Russian airplanes (1950s onwards) and modern developments (1980s onwards). Selected experimental aircraft and laboratory concepts are mentioned, where these appear to advance the state-of-the-art. Power plants evolved from internal combustion engines to the modern gas turbine engines requiring new solutions. Engine layouts and propulsion configurations are analysed where appropriate. It is concluded that propulsive efficiency can only be achieved at a cost of multiple engineering problems, some of which remain unsolved.
Use of a Community Engagement and Research Core model to enhance primary care provider recruitment: A case example
Authors: Rishel Brakey Heidi , Martinez Julia M. , Sussman Andrew L. , McWethy Magdalena M. , Martinez Justin , Cordova Carla N. , Salvador Julie G.
Published: November 2022

Persistent barriers exist to engage rural providers in research and training. Provider shortages exacerbate these challenges, leading to a scarcity of time and limiting motivation to participate in research. We present application of an innovative engagement model to increase rural primary care provider participation in research. Using our Community Engagement and Research Core, we demonstrate that fundamental principles of training and expertise, attention to efficiency and multitasking, and commitment to community are important for addressing provider recruitment barriers. We encourage other Clinical and Translational Science Centers to provide similar services to their local investigators to enhance provider engagement in research.
Is compulsory voting a solution to low and declining turnout? Cross-national evidence since 1945
Authors: Kostelka Filip , Singh Shane P. , Blais André
Published: November 2022

Despite the substantial body of research on compulsory voting's (CV) relationship with turnout, much remains unknown about the role of different types of CV rules, their enforcement, and their ability to prevent the secular turnout decline observed around the world. Moreover, existing studies that leverage changes to CV laws are limited to a single country. We assemble rich new data on voter turnout and electoral legislation that, we believe, include the most accurate and extensive cross-national measure of CV to date. We test three theoretically derived hypotheses: that CV enforcement matters for participation; that enforcement's effect is conditioned by state capacity; and that, only when CV is enforced, will it mitigate voter turnout's post-1970 tendency to decline. We find support for each. We also find that the nature of sanctions for non-voting is irrelevant for participation.
Extraterritorial, Universal, or Transnational Human Rights Law?
Authors: Palombo Dalia
Published: November 2022

Traditionally, international human rights adjudication relied on the paradigm of extraterritoriality on the rare occasions when it was confronted with cross-border cases. This paradigm recognises only limited circumstances in which states bear extraterritorial human rights obligations. However, with globalisation, transboundary human rights cases have multiplied. This emerging litigation increasingly reveals that the paradigm of extraterritoriality is no longer fit to address global crises. Extraterritoriality demands effective control over a territory, or authority and control over a person, for a state to exercise jurisdiction outside its territory. Thus, several cases of cross-border human rights abuses are inevitably barred on jurisdictional grounds. This is particularly true for obligations of a global character, which are, by their very nature, completely unrelated to the control that states exercise over territories or people. It is therefore necessary to look beyond extraterritoriality. This article analyses the competing paradigms of universality and transnationality as they have been adopted by domestic courts. It argues that international human rights adjudication should reconceptualise extraterritoriality against the background of universality and transnationality to address global crises.
Effects of genotypes and sowing methods on growth, phenology and yield of fonio (Digitaria exilis) in Benin
Authors: Kanlindogbè Cyrille , Sekloka Emmanuel , Séïdou Moudjaïdou , Kora Ayouba Tikin
Published: November 2022

Fonio is an identity and orphan cereal of Africa whose production system has remained traditional. This work assessed the responses of selected genotypes of fonio to different sowing methods in Benin from 2018 to 2019. Split plot design with three replicates was used. Four genotypes from mass selection and two control varieties were randomly arranged in four planting modalities (ordinary broadcast sowing, continuous row sowing at inter-rows 20 cm (SLC20) and 25 cm (SLC25) and in seed hole sowing (SP25 × 20)). Agro-morphological data were collected and subjected to variance and multivariate analyses. On all traits, interaction (variety × sowing × year) was not significant. Other interactions (variety × sowing, variety × year, sowing × year) were significant on some morpho-phenological traits. Genotypes AS19-1-1, AS1 and ‘Yoro’ were the earliest, especially AS19-1-1 presenting sowing–heading cycle less of 65 days. Improved genotypes were the most grain yielding mainly AS15-1-1 (1056.5 kg/ha) showing an excess of 405.9 kg/ha compared to control ‘Yoro’ (650.9 kg/ha), the least performing. However, control ‘Iporawan’ was the most yielding in dry matter (>8000 kg/ha). Based on sowing methods, plant density was negatively correlated with tiller number. The best growth and grain yield performances were obtained in broadcast sowing and especially in SLC25 (911.4 kg/ha). Cropping systems in which the new genotypes (AS1, AS13-1, AS15-1-1, 19-6-1-1) sown in continuous rows at 20–25 cm apart, or by broadcasting, were better in terms of grain yield (971.7 kg/ha). These systems constitute cultivation innovation which will enable to optimize fonio production and bring added value.
The musical lives of young children in Aotearoa New Zealand
Authors: Evans Rebecca Jane , Dean Bronya , Byett Fergus
Published: November 2022

Despite a global interest in the musical experiences of young children, the everyday musical lives of young New Zealanders remain unexamined. Using data collected through the Growing Up in New Zealand longitudinal study, we explore the early musical experiences of approximately 6,800 infants and toddlers. Data collected from the primary caregivers and their partners pre-birth, when the children were 9 months old, and 2 years old are used to explore five areas: parental singing; active musical play; music listening; involvement in music groups; and participation in wider cultural events. Musical engagement is analysed with respect to various child, parental and family characteristics, including parental education, socio-economic status, and parental knowledge of and appreciation for the arts. The results provide a holistic description of the musical environments of young children in Aotearoa New Zealand.
Upregulation of miR-184 and miR-19a-3p induces endothelial dysfunction by targeting AGO2 in Kawasaki disease
Authors: Liao Jinwen , Guo Xin , Fan Xue , Zhang Xiangtong , Xu Mingguo
Published: November 2022

Background:

Endothelial dysfunction is a marked feature of Kawasaki disease during convalescence, but its pathogenesis is currently unclear. Circulating microRNAs (miRNAs) are associated with the progression of Kawasaki disease. However, the role and mechanism of circulating miRNAs in endothelial dysfunction are largely unknown. Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA-210-3p, miR-184 and miR-19a-3p, compared to non-Kawasaki disease febrile controls. This study aimed to investigate the effects of these three miRNAs on endothelial function.

Methods:

Overexpression of miRNAs in human umbilical vein endothelial cells was done by transfection of miRNA mimics. The tube formation assay was used to evaluate the function of human umbilical vein endothelial cells. The potential binding sites of miRNAs on 3’untranslated regions were predicted by using TargetScan database and validated by dual luciferase reporter assay. The protein expression of AGO2, PTEN and VEGF in human umbilical vein endothelial cells was detected by Western blot. Overexpression of AGO2 in human umbilical vein endothelial cells was done by transfection of AGO2 expression plasmids.

Results:

Overexpression of miRNA-184 and miRNA-19a-3p, but not miR-210-3p, impaired the function of human umbilical vein endothelial cells. Mechanistically, miR-184 and miR-19a-3p could target the 3’untranslated regions of AGO2 mRNA to downregulate its expression and subsequently impede the AGO2/PTEN/VEGF axis. To be noted, the rescue of the expression of AGO2 remarkably recovered the function that was impaired by overexpression of miRNA-184 and miRNA-19a-3p.

Conclusions:

This study suggested that miR-184 and miR-19a-3p could target AGO2/PTEN/VEGF axis to induce endothelial dysfunction in Kawasaki disease.
What factors empower general practitioners for early cancer diagnosis? A 20-country European Delphi Study
Authors: Tzanis George , Harris Michael , Brekke Mette , Marzo-Castillejo Mercè , Cifcili Saliha Serap , Wawrzynek Wojciech , Flamm Maria , Buono Nicola , Márkus Bernadett , Zacay Galia , Skuja Ilze , Adzic Zlata Ozvacic , Iacob Mihai , Asenova Radost , Petek Davorina , Buczkowski Krzysztof , Curtis Pamela , Pilv-Toom Liina , Hoffman Robert , Smyrnakis Emmanouil
Published: November 2022

Background:

Some symptoms are recognised as red flags for cancer, causing the General Practitioner (GP) to refer the patient for investigation without delay. However, many early symptoms of cancer are vague and unspecific, and in these cases, a delay in referral risks a diagnosis of cancer that is too late. Empowering GPs in their management of patients that may have cancer is likely to lead to more timely cancer diagnoses.

Aim:

To identify the factors that affect European GPs’ empowerment in making an early diagnosis of cancer.

Methods:

This was a Delphi study involving GPs in 20 European countries. We presented GPs with 52 statements representing factors that could empower GPs to increase the number of early cancer diagnoses. Over three Delphi rounds, we asked GPs to indicate the clinical relevance of each statement on a Likert scale.

The final list of statements indicated those that were considered by consensus to be the most relevant.

Results:

In total, 53 GPs from 20 European countries completed the Delphi process, out of the 68 GPs who completed round one. Twelve statements satisfied the pre-defined criteria for relevance. Five of the statements related to screening and four to the primary/secondary care interface. The other selected statements concerned information technology (IT) and GPs’ working conditions. Statements relating to training, skills and working efficiency were not considered priority areas.

Conclusion:

GPs consider that system factors relating to screening, the primary-secondary care interface, IT and their working conditions are key to enhancing their empowerment in patients that could have cancer. These findings provide the basis for seeking actions and policies that will support GPs in their efforts to achieve timely cancer diagnosis.
LPF/dual-BPF/UWB-BPF reconfiguration utilizing DGS resonators and lumped capacitors
Authors: Mohamed Hesham A. , Ali Wael A. E. , Ibrahim Ahmed A.
Published: November 2022

In this work, three successive filter models based on defected ground structure (DGS) techniques are designed, fabricated, and tested to be utilized for different wireless applications. The filters are printed on a RO5880 substrate of an overall size of 22 × 11 × 0.8 mm3. Three DGSs are etched from the ground plane to achieve the suggested band stop features for all frequencies above 10 GHz. The first model is a low-pass filter that succeeded to pass all frequencies below 10 GHz, the second model is a bandpass filter that operated at 4.5 and 9 GHz after using a pair of interdigital capacitors, and the third model covered all ultra-wideband frequency range when a pair of lumped capacitors is utilized instead of the interdigital capacitors. Good consistency between simulated and measured outcomes is achieved for each of the three filters confirming their suitability to be embedded in small-sized wireless devices.
From a Love of Nature to a World of Earth Observations
Authors: King Michael D.
Published: November 2022

This article is a reflection on my career in Earth remote sensing and its evolution from an early childhood love of nature. I recount the influence of key people along the way to my development as an atmospheric scientist, and ultimately to my role as senior project scientist of NASA's Earth Observing System, one of the largest science program in the world in the 1990s and 2000s. Special focus is on unexpected encounters and opportunities to learn and explore, and ultimately to play a role in the remote sensing of aerosol and cloud properties from the ground, aircraft, and satellites. A major focus of much of my research at NASA Goddard Space Flight Center was on the development and exploitation of the Moderate Resolution Imaging Spectroradiometer that ultimately flew on NASA's Terra and Aqua satellites. As a participant on this science team, I had the opportunity to learn from and collaborate with biological oceanographers, atmospheric scientists, and terrestrial ecologists, and ultimately to publish in each of these areas, far more than my basic academic “home.”
Drivers and Mechanisms of the 2021 Pacific Northwest Heatwave
Authors: Schumacher D. L. , Hauser M. , Seneviratne S. I.
Published: November 2022

In late June 2021, western North America, and in particular the Pacific Northwest experienced a heatwave with temperatures usually only encountered in hot desert climates. Using a blend of reanalysis data and Earth System Model (ESM) simulations, we disentangle the physical drivers underlying this exceptional event. Our analysis highlights the role of the anticyclonic circulation aloft, which converted previously gained potential energy—some of which by intense latent heating thousands of kilometers upwind over the North Pacific—back into sensible heat through subsidence. We demonstrate that this upwind latent heat release did not only result in a hot troposphere above the heatwave region, but also contributed directly to escalating near‐surface temperatures. Facilitated by the mountainous terrain and dry soils in the region, deep atmospheric boundary layers were established over the course of several days, connecting the air close to Earth's surface to a massive heat reservoir many kilometers above. Anomalous soil moisture acted to raise the heatwave temperatures by 3°C in a large region during the peak of the event, with local anomalies exceeding 5°C. Overall, we conclude that this heatwave was the outcome of an intricate interplay between dynamic and thermodynamic processes. ESM experiments suggest that the same large‐scale atmospheric circulation fueled by enhanced thermodynamic drivers, such as more available moisture for condensation upwind, could enable even more extreme near‐surface temperatures, in particular in a warmer climate.
Structure and Present State of the Astroni Volcano in the Campi Flegrei Caldera in Italy Based on Multidisciplinary Investigations
Authors: Isaia Roberto , Di Giuseppe Maria Giulia , Troiano Antonio , Avino Rosario , Caliro Stefano , Santi Alessandro , Vitale Stefano
Published: November 2022

Despite its known reconstructed volcanic history, the structural setting and present state of the Astroni Volcano of the Campi Flegrei caldera in Italy are still poorly defined. Through structural, geophysical, and geochemical investigations, we elucidate the structure and present volcanic activity of the Astroni Volcano, which hosts tuff cones, scoriae cones, lava domes, and lakes on the crater floor. A volcano‐tectonic analysis focused on the entire volcano edifice, coupled with electrical resistivity tomography of the shallower part of the Astroni crater, revealed the main rock formations, faults, and possible fluid patterns within the first 150 m depth. Two main NE–SW and NW–SE trending fault sets were imaged using electrical resistivity modeling and measurements along the wall of the volcanic edifice; they likely delimit a maar‐like structure resulting from the highest energetic subplinian Astroni 6 eruption event and acted as magma pathways during the late eruptive activity stage. A 3D view of the reconstructed resistivity model revealed both deep root‐conduit‐like structures and shallower dome‐like shapes for volcanic edifices on the crater floor. Gas and carbon compositions in the NNE sectors of the Astroni Lago Grande are similar to those of the Solfatara fumarole fluids, suggesting common hydrothermal origin and a possible link with a deep hydrothermal reservoir. This fluid‐emission area along the border of the younger volcanic structure exhibits a +40°C maximum soil‐temperature anomaly. The proposed volcano‐tectonic architecture should improve the unrest scenarios in case of reactivation in this Campi Flegrei caldera sector and the monitoring strategies for the Astroni Volcano.
Magnetic Storms During the Space Age: Occurrence and Relation to Varying Solar Activity
Authors: Mursula Kalevi , Qvick Timo , Holappa Lauri , Asikainen Timo
Published: November 2022

We study the occurrence of magnetic storms in space age (1957–2021) using Dst and Dxt indices. We find 2,526/2,743 magnetic storms in the Dxt/Dst index, out of which 45% are weak, 40% moderate, 12% intense and 3% major storms. Occurrence of storms in space age follows the slow decrease of sunspot activity and the related change in solar magnetic structure. We quantify the sunspot—coronal mass ejection (CME) storm relation in the five cycles of space age. We explain how the varying solar activity changes the structure of the heliospheric current sheet (HCS), and how this affects the high‐speed solar wind stream (HSS)/corotating interaction region (CIR) storms. Space age started with a record number of storms in 1957–1960, with roughly one storm per week. Solar polar fields attained their maximum in cycle 22, which led to an exceptionally thin HCS, and a space age record of large HSS/CIR storms in 1990s. In the minimum of cycle 23, for the only time in space age, CME storm occurrence reduced below that predicted by sunspots. Weak sunspot activity since cycle 23 has weakened solar polar fields and widened the HCS, which has decreased the occurrence of large and moderate HSS/CIR storms. Because of a wide HCS, the Earth has spent 50% of its time in slow solar wind since cycle 23. The wide HCS has also made large and moderate HSS/CIR storms occur in the early declining phase in recent cycles, while in the more active cycles 20–22 they occurred in the late declining phase.
Direct Evidence for Dextral Shearing in the Shanxi Graben System: Geologic and Geomorphologic Constraints From the North Liulengshan Fault
Authors: Luo Quanxing , Li Youli , Schoenbohm Lindsay , Rimando Jeremy , Hu Xiu , Guo Ailun , Zhao Junxiang , Li Xinnan , Liu Qingri , Jiang Shanru , Li Chuanyou , Sun Kai
Published: November 2022

The Shanxi Graben System (SGS) is one of the first‐order Cenozoic tectonic features in North China. Understanding the kinematics of this tectonic system is crucial for deciphering the mechanism of continental rifting and the deformation pattern across North China. Although the SGS has long been thought to be a right‐lateral, transtensional shear zone, the geologic and geomorphologic evidence for dextral strike‐slip along its internal faults was slim and even controversial. Field investigations, interpretations of satellite imagery, and construction of decimeter‐scale digital elevation models from unmanned aerial vehicle surveys were used in this work to investigate the tectonic geomorphology of the eastern segment of the North Liulengshan Fault (NLSF) in the northern SGS. Although this fault segment was previously thought to be a pure normal fault, the presence of geomorphic features such as right‐laterally offset terrace risers and gullies, along with an analysis of fault‐slip data, suggests a component of right‐lateral strike‐slip displacement. Combined with optically stimulated luminescence dating of offset fluvial terraces, the late Quaternary right‐lateral strike‐slip and vertical slip rates of this fault segment are both estimated to be ∼0.2–0.3 mm/yr. The discovery of dextral strike‐slip along the NLSF provides compelling direct evidence for determining the dextral transtensional kinematics of the SGS. This puts new constraints on our knowledge that the evolution of the SGS is primarily driven by the outward expansion and growth of the Tibetan Plateau and supports the “bookshelf” rotation kinematic model for North China.
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Authors: Collins Meghan A. , Ji Jie Lisa , Chung Yoonho , Lympus Cole A. , Afriyie-Agyemang Yvette , Addington Jean M. , Goodyear Bradley G. , Bearden Carrie E. , Cadenhead Kristin S. , Mirzakhanian Heline , Tsuang Ming T. , Cornblatt Barbara A. , Carrión Ricardo E. , Keshavan Matcheri , Stone Wiliam S. , Mathalon Daniel H. , Perkins Diana O. , Walker Elaine F. , Woods Scott W. , Powers Albert R. , Anticevic Alan , Cannon Tyrone D.
Published: November 2022

Progressive grey matter loss has been demonstrated among clinical high-risk (CHR) individuals who convert to psychosis, but it is unknown whether these changes occur prior to psychosis onset. Identifying illness-related neurobiological mechanisms that occur prior to conversion is essential for targeted early intervention. Among participants in the third wave of the North American Prodrome Longitudinal Study (NAPLS3), this report investigated if steeper cortical thinning was observable prior to psychosis onset among CHR individuals who ultimately converted (CHR-C) and assessed the shortest possible time interval in which rates of cortical thinning differ between CHR-C, CHR non-converters (CHR-NC), and health controls (HC). 338 CHR-NC, 42 CHR-C, and 62 HC participants (age 19.3±4.2, 44.8% female, 52.5% racial/ethnic minority) completed up to 5 MRI scans across 8 months. Accelerated thinning among CHR-C compared to CHR-NC and HC was observed in multiple prefrontal, temporal, and parietal cortical regions. CHR-NC also exhibited accelerated cortical thinning compared to HC in several of these areas. Greater percent decrease in cortical thickness was observed among CHR-C compared to other groups across 2.9±1.8 months, on average, in several cortical areas. ROC analyses discriminating CHR-C from CHR-NC by percent thickness change in a left hemisphere region of interest, scanner, age, age2, and sex had an AUC of 0.74, with model predictive power driven primarily by percent thickness change. Findings indicate that accelerated cortical thinning precedes psychosis onset and differentiates CHR-C from CHR-NC and HC across short time intervals. Mechanisms underlying cortical thinning may provide novel treatment targets prior to psychosis onset.
Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway
Authors: Seo Jiyeon , Hwang Hongik , Sohn Heesung , Cho Eunsil , Jung Sunmin , Kim Soohyun , Um Seung Min , Kim Ji Yeon , Kang Muwon , Choi Yuri , Kim Jong-Hwan , Kim Mirang , Kim Seon-Young , Lee Sun-Kyung , Ahnn Joohong , Rhim Hyewhon , Jo Dong-Gyu , Kim Eunjoon , Park Mikyoung
Published: November 2022

Spatial learning and memory flexibility are known to require long-term potentiation (LTP) and long-term depression (LTD), respectively, on a cellular basis. We previously showed that cyclin Y (CCNY), a synapse-remodeling cyclin, is a novel actin-binding protein and an inhibitory regulator of functional and structural LTP in vitro. In this study, we report that Ccny knockout (KO) mice exhibit enhanced LTP and weak LTD at Schaffer collateral-CA1 synapses in the hippocampus. In accordance with enhanced LTP, Ccny KO mice showed improved spatial learning and memory. However, although previous studies reported that normal LTD is necessary for memory flexibility, Ccny KO mice intriguingly showed improved memory flexibility, suggesting that weak LTD could exert memory flexibility when combined with enhanced LTP. At the molecular level, CCNY modulated spatial learning and memory flexibility by distinctively affecting the cofilin-actin signaling pathway in the hippocampus. Specifically, CCNY inhibited cofilin activation by original learning, but reversed such inhibition by reversal learning. Furthermore, viral-mediated overexpression of a phosphomimetic cofilin-S3E in hippocampal CA1 regions enhanced LTP, weakened LTD, and improved spatial learning and memory flexibility, thus mirroring the phenotype of Ccny KO mice. In contrast, the overexpression of a non-phosphorylatable cofilin-S3A in hippocampal CA1 regions of Ccny KO mice reversed the synaptic plasticity, spatial learning, and memory flexibility phenotypes observed in Ccny KO mice. Altogether, our findings demonstrate that LTP and LTD cooperatively regulate memory flexibility. Moreover, CCNY suppresses LTP while facilitating LTD in the hippocampus and negatively regulates spatial learning and memory flexibility through the control of cofilin-actin signaling, proposing CCNY as a learning regulator modulating both memorizing and forgetting processes.
Dual [68Ga]DOTATATE and [18F]FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms: a multicentre validation of the NETPET score
Authors: Chan David L. , Hayes Aimee R. , Karfis Ioannis , Conner Alice , Furtado O’Mahony Luke , Mileva Magdalena , Bernard Elizabeth , Roach Paul , Marin Gwennaëlle , Pavlakis Nick , Schembri Geoffrey , Gnanasegaran Gopinath , Marin Clementine , Vanderlinden Bruno , Navalkissoor Shaunak , Caplin Martyn E. , Flamen Patrick , Toumpanakis Christos , Bailey Dale L.
Published: November 2022

Background

Gastroenteropancreatic neuroendocrine neoplasms (GEPNENs) are heterogeneous in clinical course, biology, and outcomes. The NETPET score predicts survival by scoring uptake on dual [68Ga]DOTATATE and [18F]FDG PET/CT scans. We aimed to validate previous single-centre findings in a multicentre, international study.

Methods

Dual scans were assigned a NETPET score of P1 (DOTATATE positive/FDG negative), P2–4 (DOTATATE positive/FDG positive), or P5 (DOTATATE negative/FDG positive). NETPET score, histological grade, age at diagnosis, and presence/absence of extrahepatic disease were compared to overall survival/time to progression on univariate and multivariate analysis.

Results

319 metastatic/unresectable GEPNEN patients were included. The NETPET score was significantly associated with overall survival and time to progression on univariate and multivariate analysis (all p < 0.01). Median overall survival/time to progression was 101.8/25.5 months for P1, 46.5/16.7 months for P2–4, and 11.5/6.6 months for P5. Histological grade correlated with overall survival and time to progression on univariate and multivariate analysis (all p < 0.01), while presence/absence of extrahepatic disease did not. Age at diagnosis correlated with overall survival on univariate and multivariate analysis (p < 0.01). The NETPET score also correlated with histological grade (p < 0.001).

Conclusion

This study validates the NETPET score as a prognostic biomarker in metastatic GEPNENs, capturing the complexity of dual PET imaging.
Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis
Authors: Ding Yayun , Gong Pixia , Jiang Junjie , Feng Chao , Li Yanan , Su Xiao , Bai Xiaojing , Xu Chenchang , Liu Chunxiao , Yang Jianxin , Fang Jiankai , Ji Xiaocao , Chen Yongjing , Li Peishan , Guo Lingchuan , Shao Changshun , Shi Yufang
Published: November 2022

Psoriasis is currently an incurable skin disorder mainly driven by a chronic inflammatory response. We found that subcutaneous application of umbilical cord- derived mesenchymal stem/stromal cells (MSCs) primed by IFN-γ and TNF-α, referred to as MSCs-IT, exhibited remarkable therapeutic efficacy on imiquimod (IMQ)-induced psoriasis-like inflammation in mice. Neutrophil infiltration, a hallmark of psoriasis, was significantly reduced after treatment with MSCs-IT. We further demonstrated that the effects of MSCs-IT were mediated by tumor necrosis factor (TNF) stimulating gene-6 (TSG-6), which was greatly upregulated in MSCs upon IFN-γ and TNF-α stimulation. MSCs transduced with TSG-6 siRNA lost their therapeutic efficacy while recombinant TSG-6 applied alone could also reduce neutrophil infiltration and alleviate the psoriatic lesions. Furthermore, we demonstrated that TSG-6 could inhibit neutrophil recruitment by decreasing the expression of CXCL1, which may be related to the reduced level of STAT1 phosphorylation in the keratinocytes. Thus, blocking neutrophil recruitment by MSCs-IT or TSG-6 has potential for therapeutic application in human psoriasis.
Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
Authors: Liechti Thomas , Iftikhar Yaser , Mangino Massimo , Beddall Margaret , Goss Charles W. , O’Halloran Jane A. , Mudd Philip A. , Roederer Mario
Published: November 2022

Severe COVID-19 causes profound immune perturbations, but pre-infection immune signatures contributing to severe COVID-19 remain unknown. Genome-wide association studies (GWAS) identified strong associations between severe disease and several chemokine receptors and molecules from the type I interferon pathway. Here, we define immune signatures associated with severe COVID-19 using high-dimensional flow cytometry. We measure the cells of the peripheral immune system from individuals who recovered from mild, moderate, severe or critical COVID-19 and focused only on those immune signatures returning to steady-state. Individuals that suffered from severe COVID-19 show reduced frequencies of T cell, mucosal-associated invariant T cell (MAIT) and dendritic cell (DC) subsets and altered chemokine receptor expression on several subsets, such as reduced levels of CCR1 and CCR2 on monocyte subsets. Furthermore, we find reduced frequencies of type I interferon-producing plasmacytoid DCs and altered IFNAR2 expression on several myeloid cells in individuals recovered from severe COVID-19. Thus, these data identify potential immune mechanisms contributing to severe COVID-19.
Evaluating cancer etiology and risk with a mathematical model of tumor evolution
Authors: Pénisson Sophie , Lambert Amaury , Tomasetti Cristian
Published: November 2022

Recent evidence arising from DNA sequencing of healthy human tissues has clearly indicated that our organs accumulate a relevant number of somatic mutations due to normal endogenous mutational processes, in addition to those caused by environmental factors. A deeper understanding of the evolution of this endogenous mutational load is critical for understanding what causes cancer. Here we present a mathematical model of tumor evolution that is able to predict the expected number of endogenous somatic mutations present in various tissue types of a patient at a given age. These predictions are then compared to those observed in patients. We also obtain an improved fitting of the variation in cancer incidence across cancer types, showing that the endogenous mutational processes can explain 4/5 of the variation in cancer risk. Overall, these results offer key insights into cancer etiology, by providing further evidence for the major role these endogenous processes play in cancer.
mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
Authors: Zhang Kuan , Yao Erica , Chuang Ethan , Chen Biao , Chuang Evelyn Y. , Chuang Pao-Tien
Published: November 2022

Formation of branched organs requires sequential differentiation of stem cells. In this work, we find that the conducting airways derived from SOX2+ progenitors in the murine lungs fail to form without mTOR complex 1 (mTORC1) signaling and are replaced by lung cysts. Proximal-distal patterning through transitioning of distal SOX9+ progenitors to proximal SOX2+ cells is disrupted. Mitochondria number and ATP production are reduced. Compromised mitochondrial capacity results in a similar defect as that in mTORC1-deficient lungs. This suggests that mTORC1 promotes differentiation of SOX9+ progenitors to form the conducting airways by modulating mitochondrial capacity. Surprisingly, in all mutants, saccules are produced from lung cysts at the proper developmental time despite defective branching. SOX9+ progenitors also differentiate into alveolar epithelial type I and type II cells within saccules. These findings highlight selective utilization of energy and regulatory programs during stem cell differentiation to produce distinct structures of the mammalian lungs.