bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and Safety of Cysteamine in Melasma in Patients of Skin of Colour: A Brief Report
Authors: Sarkar Rashmi , Sahu Anjali , Mendiratta Vibhu
Published: February 2025

Background:

Melasma is a common disorder of pigmentation. Traditional treatments often come with limitations, prompting the need for alternative newer therapies. Cysteamine cream, a new topical depigmenting drug, has shown potential in treating melasma while maintaining a good safety profile.

Aim:

This case series aims to evaluate the efficacy and safety of cysteamine cream in treating melasma in patients of skin of colour (Fitzpatrick’s skin types III, IV, and V).

Patients and Methods:

Ten Indian women with Fitzpatrick skin types III–V with epidermal melasma diagnosed clinically and by Wood’s lamp examination, with history of no other medications other than sunscreen use in the last 4 weeks, applied cysteamine cream (5% cysteamine hydrochloride) once daily for 15 minutes, followed by rinsing with water, over 6 weeks. Broad-spectrum sunscreen with SPF 30+ was used during the day. The primary outcomes were the modified Melasma Area and Severity Index (mMASI) score and patients’ satisfaction score.

Results:

All patients showed a significant reduction in mMASI scores, with an average improvement of 29.72%. High patient satisfaction (44.6%) was reported, and adverse effects reported in minority (20%) were minimal, including transient mild stinging and lightening of surrounding skin.

Limitations:

Small sample size, lack of a control group, and no long-term follow-up.

Conclusion:

Cysteamine cream is an effective and safe treatment for melasma in women of colour. This case series supports its use as a first-line therapy for melasma, offering a promising option for patients who may experience adverse effects from traditional treatments.
Construction and Validation of a Novel “Pruritus Impact Scale” (PIS) for Assessment of Chronic Pruritus
Authors: Saugat Dileep , Mittal Asit , Vyas Kapil , Kaushik Pratap Bhan , Gupta Lalit , Maheshwari Kriti
Published: February 2025

Background:

Currently available pruritus assessment tools may not always fulfill the needs of the Indian population and populations who share similar sociocultural backgrounds. To overcome this limitation, a new assessment tool “Pruritus Impact Scale (PIS)” was constructed and validated.

Aims and Objectives:

The primary objective is to construct and validate the novel PIS. The secondary objective is to evaluate the responsiveness of PIS to changes in symptoms.

Patients and Methods:

This study design was cross-sectional for the primary objective and longitudinal for the secondary objective. The study recruited 435 patients of chronic pruritus of different etiologies for the construction of the PIS scale. Patients were asked to fill out four different pruritus measuring tools i.e., Numerical Rating Scale (NRS), Dermatology Life Quality Index (DLQI), 12-item Pruritus Severity Score (PSS), and newly constructed PIS. The PIS was derived from existing standard assessment tools with certain modifications to keep a balance of psychometric properties of the scale and the sociocultural needs of the population. The validity and reliability of the scale was assessed. For detecting the response of PIS to change in pruritus intensity, 276 patients were followed and were instructed to refill all four scales at 6 weeks from the baseline. The responsiveness was judged by comparing the mean score of all scales at baseline with the mean score at 6 weeks. In addition, the changes in the scores among all 4 scales were correlated and compared.

Results:

PIS showed strong internal consistency (Cronbach α = 0.882) and positively correlated with other validated pruritic tools such as NRS (ρ = 0.938, P < 0.0001), DLQI (ρ = 0.914, P < 0.01) and 12- PSS (ρ = 0.913, P < 0.001) at baseline. PIS showed satisfactory reproducibility at 3-hour intervals (Cronbach α = 0.994). Responsiveness to change in pruritus as measured by PIS at 6 weeks reassessment was correlated well with the changes in NRS (ρ = 0.689, P value < 0.0001), DLQI (ρ = 0.586, P value < 0.0001) and 12-PSS (ρ = 0.928, P value <0.0001).

Limitations:

A noteworthy limitation of the present study is the lack of comparison of different items (within a construct) comprised in different tools used for comparison.

Conclusions:

The newly constructed PIS is a valid tool in the studied population.
A Nomogram Prediction Model for Clinical Outcome of Trauma-induced Coagulopathy Patients with Severe Multiple Trauma
Authors: Shen Jun , Xu Feng
Published: February 2025

Introduction:

The objective of this study was to investigate the predictive value of thromboelastography (TEG) combined with conventional coagulation test parameters for the clinical outcome of patients with trauma-induced coagulopathy (TIC) and establish and evaluate a clinical nomogram for predicting the prognosis of TIC patients.

Methods:

Clinical data of severe multiple trauma patients who underwent emergency treatment in the hospital from November 2018 to August 2021 were enrolled retrospectively. The prognosis was evaluated according to the length of hospital stay and the 30-day survival rate. Multivariable logistic regression model was used to evaluate the correlation between TEG parameters and clinical outcomes. A nomogram model was constructed and the receiver operating characteristic (ROC) curve was used to evaluate the predictive value.

Results:

Univariate analysis indicated that there were significant differences in age, hypertension, temperature fluctuation (>3°C), transfusion, kinetics time (K), angle (α) value, maximal amplitude (MA), and international normalized ratio between the good and poor outcome group (P < 0.05). Multivariate logistic regression analysis showed that age, Glasgow Coma Scale scores, temperature fluctuation (>3°C), and MA parameters were independent risk factors for poor outcome, and we established the nomogram prediction model. According to ROC curve analysis, the area under the curve for MA parameter was 0.689 (95% confidence interval [CI]: 0.610–0.760), and the corresponding sensitivity and specificity were 44.12% and 91.87%, respectively. The area under the curve for temperature fluctuation (>3°C) was 0.697 (95% CI: 0.618–0.768), and the corresponding sensitivity and specificity were 60.00% and 79.67%, respectively.

Conclusion:

TEG parameters combined with relevant clinical indicators can be used to evaluate the prognosis of TIC patients with severe multiple trauma. The establishment of correlation nomogram model was guiding significance for clinical evaluation of long-term prognosis of trauma patients.
Comparison of the donor site healing following free gingival graft procedure with and without topically applied ozonated oil as wound dressing
Authors: Dharani Kalaiselvan , Priyangha P.T.
Published: February 2025

Aim:

The present study aimed to compare and assess the wound healing efficacy of topically applied ozonated oil in palatal wounds following a free gingival graft (FGG) procedure.

Materials and Methods:

A total of 10 patients were selected and randomly assigned to control or test groups. FGG surgery was carried out on all the patients. In the test group, the patients received ozonated oil of 14 μg/mL concentration at the donor site. In the control group, the patients were not treated with ozonated oil and received only stent at the donor site. The primary outcomes calculated were postoperative pain (Visual Analog Scale) and wound healing index (Landry et al.), and the secondary outcome calculated was wound size for up to 28 days.

Results:

A total of 10 individuals completed the study. A statistically significant reduction was observed in both primary and secondary outcomes. Statistically significant differences were noted in intergroup comparison at 5th, 7th, 14th, 21st, and 28th day with a mean difference of −3.200 (P = 0.001), −2.200 (P = 0.018), −1.600 (P = 0.027), −1.800 (P = 0.037), and 2.600 (P = 0.001), respectively. In intragroup comparison, there were no statistically significant differences in the index scores in the groups on the 5th and 7th day, and a significant improvement in healing was observed in both the groups by time from the 14th to 28th day. In intergroup comparison, statistically significant differences were noted on the 5th, 7th, 21st, and 28th days with a mean difference of 1.400 (P = 0.005), 1.400 (P = 0.005), 1.000 (P = 0.020), and 1.400 (P = 0.002), respectively. Statistically significant reduction in coronal-apical dimension of wound size was noted at the 5th, 7th, 14th, 21st, and 28th day from baseline with a mean difference of −1.400 (P = 0.002), −1.200 (P = 0.040), −1.600 (P = 0.001), −2.200 (P ≤ 0.001), and −1.800 (P = 0.007), respectively. There was no statistically significant reduction in the mesiodistal dimension of wound size on the 5th and 7th day with a mean difference of − 0.600 (P = 0.174) and − 0.600 (P = 0.208). Significant differences were noted on the 14th, 21st, and 28th days from day 0 with a mean of − 1.600 (P = 0.019), −2.600 (P = 0.001), and −2.200 (P = 0.003).

Conclusion:

These results suggest that topical ozonated oil application on palatal wounds following FGG harvesting enhances tissue healing in terms of epithelialization and wound size reduction and also reduces postoperative discomfort.
Estimation of salivary sodium, potassium, and calcium levels in periodontal health and disease
Authors: Pampani Priyanka , Shenoy Santhosh , Anegundi Raghavendra Vamsi , Shekar Magesh Kumar , Dharani Kalaiselvan , Fathima Lubna
Published: February 2025

Objectives:

This study aimed to estimate and compare salivary sodium, potassium, and calcium levels in periodontal health and disease.

Materials and Methods:

A total of 150 patients were selected based on selection criteria. The selected patients underwent complete periodontal examination and were categorized into three groups – Group A, Group B, and Group C. Group A (control group) consisted of 50 patients with healthy subjects. Group B (gingivitis group) consists of 50 patients with gingivitis. Group C (periodontitis group) consists of 50 patients with Stage II/III periodontitis. Gingival index, probing pocket depth, and clinical attachment loss were measured and recorded. The unstimulated whole saliva was collected and sent for biochemical analysis using colorimetric and modified Arsenazo III method.

Results:

A statistical comparison of salivary sodium, potassium, and calcium levels was analyzed among the three groups by a one-way Analysis of Variance test. Tukey Post hoc test was used for pair-wise statistical comparison among the groups. Salivary sodium, potassium, and calcium levels between the groups showed a statistically significant difference with P < 0.001. P value was statistically higher when Group A (healthy group) compared with Group C (periodontitis) than Group A (healthy group) compared with Group B (gingivitis).

Conclusion:

Within the limitation of the current study, there was an increase in Group C (periodontitis group) concentration levels of salivary sodium, potassium, and calcium ions, which showed a statistically significant difference. However, additional studies are necessary to investigate these findings, and future periodontal research should include larger sample sizes with prospective and experimental study designs.

Clinical Relevance:

The assessment of these inorganic ions can be effectively utilized as a significant diagnostic marker of active disease in periodontal tissues. It would help the clinician identify the risk of developing periodontitis.
Stage IV, grade B periodontitis in a patient with coinfection with the human immunodeficiency virus, hepatitis C, and oral candidiasis
Authors: Bitu Thaissa Cavalcante Vieira , Silva Raphaela Canuto , Bandeira Lucas Muniz Pinto , Cunha Diana Araújo , Silva Paulo Goberlanio Barros , Nobre Átila Vinícius Vitor
Published: February 2025

Opportunistic infections are common in patients infected with human immunodeficiency virus (HIV) in acquired immunodeficiency syndrome. This case report demonstrates a clinical case of an individual with periodontitis, HIV/hepatitis C coinfection, and candidiasis, using different drugs and under irregular antiretroviral therapy. The combination of several local and systemic conditions highlights the importance of the case and the need for health professionals to know the management of these combined pathologies in the context of HIV infection. We can conclude that it is extremely important for dentists to be aware of periodontal diseases in HIV-infected patients, due to the pathogenic mechanisms associated with these pathologies.
Galectin-3 as a biomarker for periodontal disease severity in postcoronavirus disease 2019 patients: A clinical and biochemical investigation
Authors: Mithradas Nimisha , Sudhakar Uma , Rajaram Vijayalakshmi , Ram Shankar , Ravindran Navina
Published: February 2025

Background:

The relationship between coronavirus disease 2019 (COVID-19) and periodontitis has been interesting. Understanding this connection is crucial for comprehensive patient care and highlights the importance of monitoring and addressing oral health issues in an individual’s post-COVID-19 recovery. This study compared and evaluated the serum Galectin-3 (Gal-3) levels and clinical parameters in healthy individuals with chronic periodontitis with no history of COVID-19 and post-COVID-19 patients with periodontitis.

Materials and Methods:

Group I consists of 25 post-COVID-19 patients with Stage II Grade B periodontitis, 25 patients with Stage II Grade B periodontitis without any history of COVID-19 (Group II), and 25 healthy controls (Group III) were recruited for the study. Gal-3 levels in serum were assessed using an enzyme-linked immunosorbent assay (ELISA) kit. Clinical periodontal variables were measured and recorded, including clinical attachment level (CAL), plaque index (PI), and probing pocket depth (PPD). Data analyses were done using the one-way analysis of variance (ANOVA) test and Tukey’s honest significant difference post hoc tests.

Results:

Group I patients had a higher serum Gal-3 concentrations of 14.757 ng/ml compared to 11.127 ng/ml and 8.673 ng/ml in Group II and Group III, respectively, and the mean difference in Gal-3 levels was statistically significant with P = 0.000. The mean PPD, CAL, and PI were significantly high in Groups I and II compared to Groups II and III with P = 0.000.

Conclusion:

The current study’s findings demonstrated that periodontitis patients and individuals with post-COVID-19 and periodontitis had increased Gal-3 levels in the serum compared to healthy participants. This study highlights the relevance of treating periodontitis during the post-COVID-19/long-COVID era and the need to maintain oral hygiene by identifying possible biomarkers and understanding specific underlying processes.
Antimicrobial efficacy of extracts obtained from aerial part, leaves, and flowers of Sphaeranthus indicus on different periodontal pathogens: An in vitro study
Authors: Gawade Mahendra Rawaji , Agrawal Amit Arvind , Sreeram Meenakshi , Mohan Mahalaxmi
Published: February 2025

Introduction:

Sphaeranthus indicus is a medicinal plant widely used in the Indian traditional system of medicine for curing various ailments. However, there has been no report of any study testing its antimicrobial action against dental or periodontal pathogens. Hence, the aim of this study was to evaluate the in vitro antimicrobial activity of extract of whole plant, leaves, and flowers of S. indicus against four periodontal pathogens, namely, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans.

Materials and Methods:

Extracts of the aerial part (whole plant), leaves, and flowers of Sphaeranthus indicus were prepared using cold maceration and ethanol extraction. The extracts were tested for their antimicrobial activity against periodontal pathogens by using in vitro serial dilution method at concentration of 12.5, 25, 50, and 100 μg/ml. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of all three groups were determined against all four periodontal pathogenic using thioglycollate broth and chlorhexidine as a positive control.

Results:

P. gingivalis and Fusobacterium nucleatum were most susceptible to leaves extract (12.5 μg/ml and 25 μg/ml) followed by whole aerial plant extract (25 μg/ml and 50 μg/ml), but were least susceptible to flower extract (100 μg/ml). Another pathogen, T. forsythia was most susceptible to whole plant and flower extracts (25 μg/ml), followed by leaves extract (100 μg/ml). Finally, A. actinomycetemcomitans was most susceptible to flower extract (25 μg/ml), followed by equal susceptibility at 50 μg/ml concentration of either whole plant or leaves extracts.

Conclusion:

The S. indicus ethanol extracts of aerial parts, leaves, and flowers showed good antimicrobial activity against periodontal pathogens.
Comparative evaluation of the relative efficacy of autogenous tooth graft and demineralized freeze-dried bone allograft in the treatment of periodontal infrabony defects – A 6-month clinico-radiographic and biochemical study
Authors: Singh Anamika , Blaggana Vikram , Upadhyay Preeti , Tripathi Pragya , Blaggana Anshu
Published: February 2025

Context:

Demineralized freeze-dried bone allograft (DFDBA) is a commonly used biomaterial in periodontal regeneration, while autogenous tooth graft (ATG) is a newer, nearly ideal biomaterial. In the literature, in vivo studies on ATG for managing periodontal infrabony defects are rare.

Aims:

The aim of this study was to comparatively evaluate the efficacy of DFDBA and ATG in the management of periodontal infrabony defects clinically, radiologically, and biochemically.

Settings and Design:

In this randomized controlled clinical trial, 30 sites were selected based on the study criteria and randomly assigned to Group A (DFDBA) and Group B (ATG) by toss of a coin.

Materials and Methods:

Selected patients were evaluated 3–4 weeks after phase I therapy. Both the groups underwent open flap debridement: Group A sites were grafted with DFDBA and Group B with ATG. Clinico-radiological evaluation was performed at baseline, 3 months, and 6 months for pocket probing depth (PPD), clinical attachment level (CAL), and linear defect depth (LDD). Biochemical assessment was done using enzyme-linked immunosorbent assay for gingival crevicular fluid-alkaline phosphatase (GCF-ALP) at baseline and at 6 months.

Statistical Analysis:

Data obtained were subjected to parametric tests of significance (paired and unpaired t-test).

Results:

In intragroup comparison, highly significant differences (P < 0.01) were observed in PPD reduction, CAL gain, LDD reduction, and GCF-ALP levels statistically from baseline to 6 months in both the groups. However, Group B showed greater PPD reduction, CAL gain, and LDD reduction as compared to Group A (3.667 > 2.933, 2.600 > 2.000, and 2.400 > 1.533 mm, respectively). Biochemically, Group B demonstrated higher GCF-ALP levels than Group A.

Conclusions:

Within the limitations of the present study, highly significant changes were noticed in all the parameters statistically in both the groups, with ATG showing higher bone fill and ongoing bone healing at 6 months postoperatively in the management of periodontal infrabony defects.
Microscopic evaluation of the effect of low-level laser therapy on platelet-rich fibrin: An in vitro study
Authors: Suresh Sruthi Kallayil , Arishinagodi Girija Venkatesh , Patil Mallanagouda B.
Published: February 2025

Background:

Platelet-rich fibrin (PRF) serves as a natural fibrin-based biomaterial scaffold, facilitating cellular attachment. Low-level laser therapy (LLLT) may influence PRF properties through its stimulatory effects.

Aim:

The study aimed to evaluate the effect of LLLT on PRF architectural changes and platelet concentrate values.

Materials and Methods:

Thirty-four samples from seventeen subjects were included in the study, with 20 mL of blood collected from each participant. Blood was distributed into two 10 mL vacutainer tubes: one served as a control for baseline platelet and leukocyte counts, whereas the other was used for PRF preparation. The PRF samples were vertically cut into two equal parts and divided into two groups: Group I (without laser treatment) and Group II (treated with LLLT). Histological preparations were performed for all samples. The mean and standard deviation of platelet and leukocyte counts in Groups I and II were analyzed using the Statistical Package for the Social Sciences (SPSS) version 17.1. Analysis of variance (ANOVA) and post hoc tests were employed for comparisons.

Results:

Platelet and leukocyte values showed statistically significant differences, with greater cellular entrapment in Group II compared to Group I. The residual serum cell count in both groups was lower than the whole blood cell count. Microscopically, Group I displayed dense, thick fibrils with increased spacing distally, whereas Group II exhibited thinner fibrils with gradual density changes toward the distal end.

Conclusion:

PRF obtained in both groups was similar in size. Laser irradiation altered the fibrin architecture and enhanced platelet and leukocyte entrapment in PRF.
Development and characterization of novel magnesium oxide nanoparticle-impregnated chitosan-based guided tissue regeneration membrane – An in vitro study
Authors: Harris Johnisha , Gurumoorthy Kaarthikeyan
Published: February 2025

Introduction:

Although a lot of commercially available guided tissue regeneration (GTR) membranes are used, none of them could actually ensure complete bone regeneration so far and they also have certain limitations. This study aims to explore further and develop a membrane that might overcome these limitations and aid in bone regeneration for the treatment of bony defects.

Materials and Methods:

Magnesium oxide nanoparticles (MgONPs) were prepared from magnesium nitrate prepared by calcination at different temperatures and dried using filter paper under specific temperature. Later, 0.3 ml of 0.2 M 1% acetic acid was added to water and placed in the stirrer for at least 1 h. Chitosan (CS) (2%) of two different concentrations containing 0.588 g and 0.576 g of CS, respectively, was prepared and added to the previous mixture. To these concentrations, the prepared MgONPs were added and stirred using a magnetic stirrer for 1 h. Later, it was cast in the mold and dried. The prepared membrane was immersed in 1 M sodium hydroxide to neutralize acetic acid. After preparation, they were subjected to scanning electron microscope (SEM) analysis, energy-dispersive X-ray (EDAX), Fourier transform infrared spectroscopy (FTIR), and contact angle test.

Results:

In SEM analysis, spherical in size, uniformly dense, and porous agglomeration was noticed. EDAX and FTIR revealed the formation of MgONPs (magnesium oxide) in the membrane. The average contact angles of the CS with MgONPs and control membranes were 85.48° and 80.80°, respectively. Degradation analysis showed that test membrane showed a slower degradation rate than control collagen membrane at the end of the 28th day.

Conclusion:

On comparing membranes with pure CS, membranes with nanoparticles, and control collagen membranes, the membrane incorporated with nanoparticles showed more favorable positive outcomes.
On strictly elliptic K3 surfaces and del Pezzo surfaces
Authors: Comparin Paola , Montero Pedro , Prieto-Montañez Yulieth , Troncoso Sergio
Published: February 2025

This article primarily aims at classifying, on certain K3 surfaces, the elliptic fibrations induced by conic bundles on smooth del Pezzo surfaces. The key geometric tool employed is the Alexeev–Nikulin correspondence between del Pezzo surfaces with log-terminal singularities of Gorenstein index two and K3 surfaces with non-symplectic involutions of elliptic type: the latter surfaces are realized as appropriate double covers obtained from the former ones. The main application of this correspondence is in the study of linear systems that induce elliptic fibrations on K3 surfaces admitting a strictly elliptic non-symplectic involution, i.e., whose fixed locus consists of a single curve of genus

g\geq 2

. The obtained results are similar to those achieved by Garbagnati and Salgado for jacobian elliptic fibrations.
VMD-CNN-BiGRU Model for Vehicle Fuel Consumption Prediction
Considering Spatial-Functional Road Characteristics
Authors: Gao Yating , Yan Lixin , Deng Guangyang , Chen Siyuan
Published: February 2025

To accurately predict the fuel consumption of vehicles, this study proposes a
vehicle fuel consumption prediction model based on the VMD-CNN-BiGRU algorithm
by considering six road spatial features such as road grades, one-way road
attributes and intersection attributes. First, the VMD algorithm is employed to
reduce the nonlinearity and nonsmoothness of the raw data by determining the
optimal number of VMD decomposition modes. Then, the CNN-BiGRU algorithm is used
to predict each modal component after decomposition, and the obtained prediction
results are compared and analyzed with the prediction results of existing
CNN-BiGRU, EMD-CNN-BiGRU and EEMD-CNN-BiGRU models. The results show that the
VMD-CNN-BiGRU model significantly outperforms other models in terms of
prediction performance and can accurately capture the trend of vehicle fuel
consumption, thus effectively verifying the superiority and feasibility of the
model. In addition, this study provides an in-depth analysis of the correlation
between vehicle fuel consumption and time as well as spatial-functional
characteristics of roads. The results show that the macroscopic distribution of
vehicle fuel consumption is consistent with the distribution during peak traffic
hours, while there are significant differences in vehicle fuel consumption under
different road conditions.
Grupa neogotyckich kościołów projektu Michała Kowalczuka na terenie dawnego województwa lwowskiego, tarnopolskiego i stanisławowskiego
Authors: Dworzak Agata
Published: February 2025

Artykuł dotyczy grupy kościołów neogotyckich projektu architekta lwowskiego Michała Kowalczuka, powstałych na przełomie XIX i XX wieku na terenie Galicji (w województwach lwowskim, stanisławowskim i tarnopolskim). Omówiona grupa kościołów, na którą składają się realizacje w Stojanowie, Dobrotworze, Zabłotowie, Sorocku, Myślatyczach i Sieteszy, wyróżnia się wspólnymi cechami stylistycznymi i kostiumem neogotyckim. Szczególnie rozpoznawalnym elementem jest sposób formowania i dekoracji wież w fasadach. Analizie formalno-genetycznej zostały poddane wybrane realizacje architektury sakralnej z terenu Galicji, powstałe w ostatniej ćwierci XIX wieku (Teodor Talowski, Sławomir Odrzywolski, Julian Zachariewicz, Jan Sas-Zubrzycki), jako kontekst i źródło części rozwiązań zastosowanych przez Kowalczuka. Założeniem artykułu jest zwrócenie uwagi badaczy na postać drugorzędnego architekta lwowskiego Michała Kowalczuka, który nie tylko projektował, lecz także prowadził działalność na polach dydaktycznym (w Szkole Politechnicznej we Lwowie), naukowym (w stowarzyszeniach i redakcjach czasopism), inwentaryzacyjnym (rysunki zabytków m.in. Lwowa) i literackim (rozprawy naukowe publikowane w prasie i jako samodzielne monografie). Celem artykułu jest także zainspirowanie dalszych badań nad aktywnością architekta.
Pemaknaan Kenosis sebagai Motivasi untuk Menghidupi Kekristenan yang Otentik di Era Postmodern
Authors: Walui Donny Ardo Eka Dharma Putra , Martina Novalina
Published: February 2025

The postmodern era is characterized by a decadence of moral and spiritual values, including in Christian life. Many Christians lose their understanding of the true meaning of Christianity, which has an impact on behavior, moral values, and lifestyles that are contrary to the example of Jesus Christ. Church leaders tend to seek personal gain, avoid sacrifice, and serve with the wrong motivations. The Church of God is also often trapped in sin, unable to forgive, and views Christianity as a mere religion or routine. In this context, an understanding of kenosis—the self-emptying of Jesus Christ—can be a motivation to live authentic Christianity. Through a literature study with a qualitative approach, this study found that Jesus' kenosis that emphasizes obedience to God is an example for Christians to live according to His will. The meaning of kenosis invites Christians to abandon selfishness, live in holiness, and reflect the love of Christ in daily behavior. Thus, kenosis can be a spiritual foundation to restore the authenticity of Christian life in the postmodern era.
Peran Gereja Dalam Memperkuat Iman Jemaat: Strategi Mencegah Pemurtadan Di Era Modern
Authors: Christiaan John Abraham , Simon Simon
Published: February 2025

The rise of Christians apostasy to other religions underlies the researcher to conduct this research. The method used in this study is qualitative descriptive where the research report contains data citations from manuscripts, interviews, field notes, videos, personal documents, notes or other official documents to find the truth in answering this research. The finding of this study is that apostasy occurs because the theological understanding of Christians is not deep. The strategy to prevent such apostasy is that the church must utilize technology as a means for understanding the Christian faith, carry out pastoral and pastoral care to the congregation seriously, as well as monitor contemporary issues that arise through social media that attack the Christian faith in an improper way, then conduct studies and provide the congregation with a correct theological understanding, the church can also use social media to convey true Christian teachings so that the Christian congregation can know the true teachings to ward off the heresy that leads to apostasy.
The Predictive ability of Intellectual stagnation and Existential Emptiness in Psychopathic Symptoms among Inmates of Correction and Rehabilitation Centers in Jordan
Authors: Jawarneh Abdalraheem Ismaeil , Tashtoush Rami Abdullah
Published: February 2025

The study examined the predictive ability of intellectual stagnation and existential emptiness in psychopathic symptoms among inmates of correction and rehabilitation centers in Jordan. The study sample consisted of (417) inmates at correction and rehabilitation centers in the northern region (Irbid, Jerash, Ajloun, and Mafraq) selected randomly. To achieve the study objectives, scales of intellectual stagnation, existential emptiness and psychopathic symptoms were used. The results showed that the level of existential emptiness and psychopathic symptoms among inmates were moderate, while the level of intellectual stagnation was high among prisoners. The results revealed that intellectual stagnation and existential emptiness were significant predictors of psychopathic symptoms among inmates of correction and rehabilitation centers in Jordan as they accounted for (27%) of the total variance of psychopathic symptoms among inmates. In light of the results, a set of recommendations were provided and the most significant is that correction and rehabilitation centers should develop counseling programs based on the inmates’ daily activities to decrease the examined variables in this study.
Shannon-Wiener Index: Carbon Emission and Energy Consumption Structure in India
Authors: Kundu Amit , Chakraborty Barendra Nath
Published: February 2025

In this article, the ARDL model was utilized to examine the effect of GDP, rate of urbanization (UR), structure of trade (TS), proportion of coal consumption (CS), and Shannon -Wiener Index (SWI) on CO2 emissions in India over the period of 31 years (1990-2021). The SWI was used to reflect the structure of energy consumption. The outcomes of the study show that the Environmental Kuznets Curve hypothesis does not apply in India; an increase in SWI will reduce carbon emissions; and a diversified trade structure negatively affects the growth of carbon emissions.
Urbanization, Digital Systems Adoption, and Environmental Integration in the Euro-Mediterranean Region: Is the IT Transition Green?
Authors: Iormom Bruce Iortile , Iorember Paul Terhemba , Diyoke Kenneth , Abbas Jafar
Published: February 2025

This study characterized the link between urbanization, digital system adoption, and environmental integration among the Euro-Mediterranean countries. Environmental integration proxied by load capacity factor was found to be decreasing with increased digital systems adoption. While load capacity factor decreased with increased GDP, it increased with increased GDP2. The study provided evidence invalidating the Green IT theory, while supporting the load capacity curve hypothesis for the Euro-Mediterranean region.
Does Revisiting Multidimensional Energy Poverty Measurement Index Address Universal Energy Access?
Authors: Bajpayee Priyandu M , Mohanty Pratap C.
Published: February 2025

The study advocates for an update to the Multidimensional Energy Poverty Index, originally introduced by Nussbaumer et al. in 2012. By integrating developments from the past decade, the revised index enhances the existing indicators and provides a comprehensive framework for measuring household-level energy access. This update enables researchers and policymakers to evaluate energy access, formulate effective policies, mitigate energy poverty, and advance sustainable energy initiatives for all more precisely.
Which Components of Oil Prices Predict Inflation Rate? New Evidence From a Small Island Country, Fiji
Authors: Narayan Paresh Kumar , Abraham Joel
Published: February 2025

This note is about evaluating the role of oil prices and its constituents (namely, diesel, premix, kerosene and motor spirit) in predicting inflation rate. Using time-series monthly data for Fiji unlike for developed markets we do not find any evidence that oil price predicts inflation. We however find strong evidence that motor spirit and premix prices predict inflation by 2.71% and 2.27%, respectively, while diesel predicts inflation by 0.43%.
BIOGAS PRODUCTION AND CHARACTERIZATION FROM CO-DIGESTION OF CATTLE DUNG WITH MAIZE COB
Authors: Kuleve A. A. , Ande S. , Surma N. , Ichoron N. , Onah J. I.
Published: February 2025

Biogas technology is taking root in Nigeria in line with the global quest for a transition to sustainable renewable energies. This study investigates the co-digestion of cattle dung and maize cob waste for enhanced biogas production in laboratory-scale digesters. Three digesters were set up under varying experimental conditions. The results demonstrated that cattle dung and maize cob co-digestion significantly enhanced biogas production (410.20 mL) in the digester with the most optimal organic loading rate. The study showed that optimal inoculum-to-substrate ratio and organic loading rate promote the early onset of biogas production due to enhanced microbial activity. The analysis of variance (ANOVA) revealed that retention time (RT) and I/S ratio were key factors influencing biogas yield. Methane content ranged from 53.00 % in the control to 60.80 % in D2, and hydrogen sulphide concentrations were reduced in D2 compared to the control. These findings show that the co-digestion of cattle dung and maize cob waste optimizes biogas yield, and methane content, and reduces harmful gas emissions. The study demonstrates the importance of substrate selection, organic loading rate, and retention time for efficient biogas.
It’s Mermazing! Mermaiding Slang: Wordplay and Translation from American English into Brazilian Portuguese
Authors: Brezolin Adauri
Published: February 2025

In this paper, mermaiding slang, present in the American series MerPeople, is analysed as containing stylistically marked vocabulary, mainly wordplays, created through lexical blends. Following such analysis, I intend to investigate how mermaiding-related terms and phrases were transposed into Brazilian Portuguese subtitles. For that, my discussion briefly presents issues related to language varieties, the main word-formation processes used in the production of wordplays, and the main strategies adopted to translate them. Due to the inherent characteristics of that type of slang and wordplay, I also touch on creativity and humour. My results revealed that only a small percentage of the source language wordplays were transposed as such in the target language, confirming, among other things, that this type of translation is difficult and challenging. Yet, for results in Brazilian Portuguese considered below expectation, suggestions will be offered, bearing in mind that translators should possibly reproduce the wordplays in the target language since they characterise mermaiding slang.
Translation and Embodiment of Gendered Spaces: Reading The Great Indian Kitchen
Authors: Pradeep Sahana , Das Sriparna
Published: February 2025

This paper, titled ‘Translation and Embodiment of Gendered Spaces: Reading The Great Indian Kitchen’, investigates the translatability of gendered embodied spaces in Malayalam films in general, and in The Great Indian Kitchen (2021), in particular. Critical reading of the embodiment of gendered spaces, as represented in this film, results in a site where knowledge and pleasure, produced and defined by the dominant cinematic aesthetics, get subverted. The subversion offers a feminist critique of the representations of women and women’s experiences produced by popular Malayalam cinema. This subversion is visible in Malayalam cinema, which has been attempting to revise these popular gendered representations since the 2010s (Pillai, 2013, p. 26). This paper argues that these attempts become a form of feminist translation. This paper further argues that such an informed reading would enable an uninitiated reader to reinterpret the experiences of women subjects and their interactions with normative discourse/s.
From Page to Screen: Navigating the Influence of Culture on Adapted Fiction
Authors: Joy Aparna I
Published: February 2025

Renowned German director and screenwriter, Robert Schwentke holds a significant position in the annals of cinema’s history. His directorial work on The Time Traveler’s Wife (2009) stands out as an exemplary American romantic science fiction drama film. The film adaptation draws its inspiration from Audrey Niffenegger’s 2003 novel of the same name. This paper aims to undertake a comparative study, delving into the cultural disparities between the book and its cinematic counterpart, shedding light on the transformation of the fiction genre into the unique visual medium of film. The central focus of this investigation revolves around the extent to which the film’s director adhered to the source material and the creative departures made. Furthermore, we seek to unravel the distinct qualities that render this movie exceptional, despite the cultural differences from the original novel. These pivotal inquiries will be thoroughly explored in the article.
Creativity in Translation: Towards a Classification of Transcreation
Authors: Zhu Minghai
Published: February 2025

Transcreation, now burgeoning in cross-cultural communications like international advertising and marketing campaigns, is a frequently-adopted approach to literary translation and has been practised across the continents from Britain to the USA and from India to Brazil, producing such masters as Edward FitzGerald, Ezra Pound, Tagore, P. Lal and Haroldo de Campos, whose numerous transcreations are worth classifying so that training modules can be better designed for student translators and practitioners. For these people, the time is ripe to take a transcreational turn as they face huge challenges from AI-driven machine translation. After ploughing through many instances, this research classifies transcreation into two types: one with a source text and the other without. The former is sometimes called transwriting since it involves writing in addition to translation. The latter is found to be almost the same as writing or copywriting. The only difference is that the departure point of transcreation without a source text is translation while that of writing or copywriting is not. The skopos theory is used to explain the way transcreation is practised in both literary and nonliterary fields. The implications of this classification for translation teaching and translator training are also illustrated.
Principales trastornos psicológicos que generan problemas académicos en los adolescentes
Authors: Espinosa Tigre Rodolfo Moisés , Tasé Martínez María Josefa , Cuba Marrero Judith , Parra González Maritza Paola
Published: February 2025

Los trastornos psicológicos en adolescentes, como la ansiedad, la depresión, el estrés y los trastornos de conducta, representan un desafío significativo en su rendimiento académico, esta investigación tiene como objetivo analizar la relación entre estos trastornos y los problemas académicos en estudiantes de nivel secundario. Se realizó un estudio transversal no experimental con enfoque cuantitativo, aplicando un cuestionario estructurado de 32 preguntas en escala de Likert a 167 adolescentes, del cantón Morona provincia de Morona Santiago, Ecuador. La fiabilidad del instrumento fue validada con un coeficiente Alfa de Cronbach de 0.948. Se empleó análisis de correlación de Spearman y regresión lineal múltiple para evaluar la relación entre las variables. Los resultados muestran una correlación positiva fuerte (0.728, p < 0.001) entre los problemas académicos y los trastornos psicológicos, destacando que el modelo de regresión explica el 61.8% de la variabilidad en el rendimiento académico (R² = 0.618). Entre los predictores más significativos, los trastornos por ansiedad, estrés y depresión (? = 0.289, p < 0.001) mostraron el mayor impacto. Se concluye que los trastornos psicológicos afectan significativamente el desempeño escolar, por lo que se recomienda la implementación de estrategias psicoeducativas para mitigar su impacto en la población estudiantil.
Murraya koiginii: pytopharmacological,traditional and medicinal considerations
Authors: S Karthik , G Sahana K , Babu Anjali , S Hithesh Gowda H , V Meera , K Chandra Prakash , M Rupesh Kumar , R Bharathi D
Published: February 2025

The Murraya koenigii plant is frequently used as a spice, herb, and condiment as well as a traditional treatment for a number of illnesses in India. Due to their reputation as being secure, efficient, and natural, herbal products are used by about 80% of people worldwide.The goal of the current study was to review the Murraya koenigii plant's ethnobotanical, pharmacognostic, phytochemical, and pharmacological properties. A variety of tribal communities use this plant's various parts extensively. The plant's leaves are used internally for vomiting, dysentery, and as a tonic, stomachic, and carminative. Anti-helminthic and analgesic properties, cures piles, reduces body heat, thirst, inflammation, and itching. Researchers have worked to confirm the effectiveness of the plant through scientific biological screening in response to numerous claims that it can treat a variety of diseases. A review of the literature reveals some notable pharmacological properties of the plant, including cytotoxicity, cardioprotective effects, anti-inflammatory, mosquitocidal, anti-osteoporotic, anti-ulcer, anti-tumor, skin pigmentation, anti-cancer, anti-diabetic, anti-diarrheal, and many other therapeutic benefits.
Prepare and Evaluate Bio Enzyme Shampoo from Hibiscus Rosa Sinensis and Sapindus Trifoliatus.
Authors: Y Hemalatha , S Siva Kumar , N Mahathi , N Purna Pranay , N Satheesh , K Sukanya
Published: February 2025

The bio-enzymes are biological catalysts and are made up of proteins they also contain metabolites, lipids and carbohydrates. In our study the bioenzyme as prepared by using jaggery (30g), hibiscus petals (90g) and water (300 ml) by fermentation process for 1.5 months. The produced bioenzyme gave economical yield.  The bioenzyme shampoo was prepared by using produced bioenzyme and sapindustrifoliantus. Hibiscus Rosa sinensis and sapindustrifoliantus both have the good hair conditioning properties and also they have antioxidants and metabolites.  The formulated bioenzyme shampoo was evaluated for the quality and stability by physico chemical analysis and foam stability test along with wetting time estimation. All the ingredients used to formulate the shampoo was safer than synthetic commercial shampoos, and the physicochemical  evaluation showed ideal results, but further research is required to improve its quality and specially on the conditioning performance and anti dandruff activity.
Case Report on Pulmonary mucormycosis
Authors: V Vamsi , K SomaSekhar , R Sandeep , K Prabhu Kumar , B Meghana , S Sharmila , P Narayana swamy
Published: February 2025

Pulmonary mucormycosis (PM) is an uncommon fungal infection most often seen in immunocompromised patients. The fungus grows on decaying food, soil, and animal excrement. Patients usually become infected by inhalation of spores. The most common risk factors include diabetes mellitus, hematologic malignancy, and solid organ or stem cell transplant. PM can have a nonspecific appearance at imaging. For example, early imaging may show peribronchial ground-glass opacity. Later, the disease progresses to consolidation, nodules, or masses. Because patients are usually immunocompromised, the differential diagnosis often includes invasive pulmonary aspergillosis (IPA). Various radiologic findings suggestive of PM have been identified to help differentiate it from IPA. For example, the reverse halo sign is more closely associated with PM than with IPA. The reverse halo sign is an area of ground-glass opacity surrounded by a rim of consolidation. In addition, the presence of pleural effusions and more than 10 nodules is more suggestive of PM than it is of IPA. PM can progress rapidly in neutropenic patients. Identification of the hyphae in tissue by using endobronchial or percutaneous sampling can allow differentiation from IPA and help confirm the diagnosis of mucormycosis. Because of the high mortality rate associated with PM, early identification of the disease is critical for an improved likelihood of survival. A multimodality treatment approach with antifungal agents and surgical débridement has been shown to improve outcomes. The authors review the risk factors for PM, describe its imaging appearance and disease process, and describe the treatment of the disease
Concise Summary: Hemochromatosis Along with Its Cure
Authors: Srivastav Yash , Singh Ajeet , Mansoori Mohd Faijan , Madhaw Kumar
Published: February 2025

A condition known as hemochromatosis results in excessive iron deposition, which damages several organs. Hemochromatosis affects the liver, pancreas, heart, thyroid, joints, skin, gonads, and pituitary among other organs.Famous diagnostician and teacher Dr. Armand Trosseau published the first medical description of a patient with hemochromatosis in a French pathology paper in 1865.Hemochromatosis is a well-defined illness that can be brought on by mutations in any gene that restricts iron entry into the blood. It is typified by normal iron-driven erythropoiesis and hazardous iron accumulation in parenchymal cells of essential organs. When Feder et al. found in 1996 that a mutation in HFE caused hereditary hemochromatosis, it was a significant discovery for the field of hemochromatosis research.Systemic iron excess of hereditary origin resulting from a hepcidin deficiency, including reduced hepcidin-ferroportin binding activity or production, is known as hemochromatosis. A correct diagnosis of this illness is frequently challenging due to the wide range, lack of specificity, and vagueness of its signs and symptoms. The early warning signs and symptoms include arthralgia, weakness, weight loss, and stomach pain.In this review study, we discuss the pathophysiology, epidemiology, symptoms, and aetiology of hemochromatosis.