bluuebunny/crossref_metadata_2025 huggingface dataset:
Selective hydrosiloxane synthesis via dehydrogenative coupling of silanols with hydrosilanes catalysed by Fe complexes bearing a tetradentate PNNP ligand
Authors: Takeshita Tomohiro , Sato Kazuhiko , Nakajima Yumiko
Published: November 2018

Iron complexes bearing PNNP efficiently catalyse dehydrogenative coupling of silanols with silanes to selectively form various hydrosiloxanes.
Characterization of inductively coupled plasma time-of-flight mass spectrometry in combination with collision/reaction cell technology – insights from highly time-resolved measurements
Authors: Burger Marcel , Hendriks Lyndsey , Kaeslin Jérôme , Gundlach-Graham Alexander , Hattendorf Bodo , Günther Detlef
Published: November 2018

High time resolution of TOFMS allows to study variations in ion transit times caused by collisions within the pressurized cell.
Mechanisms of multiphase reactive flow using biogenically calcite-functionalized micromodels
Authors: Song Wen , Ogunbanwo Folake , Steinsbø Marianne , Fernø Martin A. , Kovscek Anthony R.
Published: November 2018

Biogenically calcite-functionalized microfluidics reveals a new grain-engulfment mechanism where protective reaction products alter reactive transport through porous CO2 storage media.
Synthesis and potential antineoplastic activity of dehydroabietylamine imidazole derivatives
Authors: Zhao Fengyi , Lu Wen , Su Fan , Xu Li , Jiang Dong , Sun Xu , Shi Jiuzhou , Zhou Mengyi , Lin Feng , Cao Fuliang
Published: November 2018

To seek more efficient and lower toxicity anticancer compounds, several imidazole combining dehydroabietylamine derivatives including organic salts (L1–L2) and amides (L3–L5) were synthesized.
New aspects of iron–copper crosstalk uncovered by transcriptomic characterization of Col-0 and the copper uptake mutant spl7 in Arabidopsis thaliana
Authors: Kastoori Ramamurthy Raghuprakash , Xiang Qingyuan , Hsieh En-Jung , Liu Kan , Zhang Chi , Waters Brian M.
Published: November 2018

Many metal and redox homeostasis genes are under the control of both iron and copper master regulators.
Galactose:PEGamine coated gold nanoparticles adhere to filopodia and cause extrinsic apoptosis
Authors: Tzelepi Konstantina , Espinosa Garcia Cristina , Williams Phil , Golding Jon
Published: November 2018

With increasing synthesis time, gold nanoparticles made with 50 : 50 α-galactose : PEGamine gradually lose ligands, show increased binding to filopodia, and become more toxic.
Measurement of the thermal conductivities of suspended MoS2 and MoSe2 by nanosecond ET-Raman without temperature calibration and laser absorption evaluation
Authors: Wang Ridong , Wang Tianyu , Zobeiri Hamidreza , Yuan Pengyu , Deng Cheng , Yue Yanan , Xu Shen , Wang Xinwei
Published: November 2018

Nanosecond ET-Raman measures the thermal conductivity of 2D materials without temperature calibration and laser absorption evaluation and features the highest accuracy.
Colloidal lead iodide nanorings
Authors: Klein Eugen , Heymann Leonard , Hungria Ana B. , Lesyuk Rostyslav , Klinke Christian
Published: November 2018

We present the synthesis and characterization of PbI2 nanorings prepared via a direct colloidal route. The ring structures are obtained by etching as prepared PbI2 nanosheets with trioctylphosphine and possess thicknesses between 20 nm and 85 nm and lateral dimensions of up to 10 μm. The formation process was analyzed and discussed as well as the electrical and optical measurements.
Scalable fabrication of nanopores in membranesviathermal annealing of Au nanoparticles
Authors: Park Taeyoung , Lee Sang Jun , Cha Jong Hwan , Choi Wonjoon
Published: November 2018

Thermal annealing of Au nanoparticles enables the scalable fabrication of isolated nanopores on a Si3N4membrane, with adjustable dimensions and distribution density.
Insights into the structure and nanomechanics of a quatsome membrane by force spectroscopy measurements and molecular simulations
Authors: Gumí-Audenis Berta , Illa-Tuset Sílvia , Grimaldi Natascia , Pasquina-Lemonche Laia , Ferrer-Tasies Lidia , Sanz Fausto , Veciana Jaume , Ratera Imma , Faraudo Jordi , Ventosa Nora , Giannotti Marina I.
Published: November 2018

Quatsomes (QS) membrane structure and nanomechanics. Promising candidates for drug delivery based on deformable vesicles.
Interlayer interactions in 2D WS2/MoS2heterostructures monolithically grown byin situphysical vapor deposition
Authors: Yang Weifeng , Kawai Hiroyo , Bosman Michel , Tang Baoshan , Chai Jianwei , Tay Wei Le , Yang Jing , Seng Hwee Leng , Zhu Huili , Gong Hao , Liu Hongfei , Goh Kuan Eng Johnson , Wang Shijie , Chi Dongzhi
Published: November 2018

MoS2/WS22D heterostructures grown byin-situreactive sputtering deposition exhibit a strong interlayer coupling and associated exciton relaxation at the interface.
Robust polyimide nanofibrous membrane with porous-layer-coated morphology by in situ self-bonding and micro-crosslinking for lithium-ion battery separator
Authors: Sun Guohua , Dong Guoqing , Kong Lushi , Yan Xiaona , Tian Guofeng , Qi Shengli , Wu Dezhen
Published: November 2018

A novel polyimide nanofibrous membrane with porous-layer-coated morphology has been successfully fabricated by an in situ self-bonding and micro-crosslinking technique.
Synthesis and cycloaddition reactions of strained alkynes derived from 2,2′-dihydroxy-1,1′-biaryls
Authors: Mistry Anish , Knighton Richard C. , Forshaw Sam , Dualeh Zakaria , Parker Jeremy S. , Wills Martin
Published: November 2018

A series of strained alkynes, based on the 2,2′-dihydroxy-1,1′-biaryl structure, were prepared in a short sequence from readily-available starting materials.
Logical design and application of prodrug platforms
Authors: Meng Qingye , Hu Hao , Zhou Liping , Zhang Yixin , Yu Bing , Shen Youqing , Cong Hailin
Published: November 2018

This review summarizes the current state of prodrugs and elaborates the logical design and future development of the prodrug platform.
A highly selective fluorescent probe for real-time imaging of bacterial NAT2 and high-throughput screening of natural inhibitors for tuberculosis therapy
Authors: Jin Yinzhu , Tian Zhenhao , Tian Xiangge , Feng Lei , Cui Jingnan , Ma Xiaochi
Published: November 2018

Fluorescent probeARHBis developed for detecting in various bacteria the activity ofN-acetyltransferase 2 (NAT2), a key enzyme in cell wall synthesis and widely considered to be a molecular target for anti-mycobacterial therapy.
Thienylbenzotriazole promoted highly active gold nanoparticles supported on N-doped graphene as efficient catalysts in water and a mechanism exploration
Authors: Ye Dongdong , Huang Ronghui , Zhu Haiyan , Zou Liang-Hua , Wang Dawei
Published: November 2018

Gold nanocomposite catalyzed alkylation of ketone with alcohol, alcohol and alcohol, particularly for amine and amine in water.
Modification of poly(amide-urethane-imide) (PAUI) thin film composite reverse osmosis membrane with nano-silver particles
Authors: Liu Li-Fen , Wu Hao , Li Rui-Han , Yu Chun-yang , Zhao Xue-Ting , Gao Cong-Jie
Published: November 2018

A novel reverse osmosis (RO) composite membrane, poly(amide-urethane-imide@Ag) (PAUI@Ag), was prepared on a polysulfone supporting film through two-step interfacial polymerization.
Corrosion and hydrogen evolution rate control for X-65 carbon steel based on chitosan polymeric ionic liquids: experimental and quantum chemical studies
Authors: Elsaeed S. M. , El Tamany El Sayed H. , Ashour H. , Zaki E. G. , Khamis E. A. , El Nagy H. A.
Published: November 2018

The corrosion performance of carbon steel was tested in four polymeric ionic liquids (PILs) that differed only in the fatty acid linked to the chitosan (CS) amine group.
Ascorbic acid sensor using a PVA/laccase-Au-NPs/Pt electrode
Authors: Lee Yuan-Gee , Liao Bo-Xuan , Weng Yu-Ching
Published: November 2018

A surface-modified electrode, PVA/laccase-Au-NPs/Pt, was prepared to sense ascorbic acid (H2A) in this study.
A microRNA-4516 inhibitor sensitizes chemo-resistant gastric cancer cells to chemotherapy by upregulating ING4
Authors: Liu Jun-bao , Chen Dan , Liu Hai-xia , Sha Huan-huan , Song Dan , Bao Ting-ting , Lu Jian-wei , Yu Chen
Published: November 2018

MicroRNA (miRNA) is an important factor in the regulation of gene transcription.
Superior ion release properties and antibacterial efficacy of nanostructured zeolites ion-exchanged with zinc, copper, and iron
Authors: Chen Shaojiang , Popovich John , Zhang Wenwen , Ganser Collin , Haydel Shelley E. , Seo Dong-Kyun
Published: November 2018

Nanostructured zeolite X as a superior host for transition-metal ion antimicrobials with rapid ion release and killing kinetics.
Purification and structural elucidation of chondroitin sulfate/dermatan sulfate from Atlantic bluefin tuna (Thunnus thynnus) skins and their anticoagulant and ACE inhibitory activities
Authors: Krichen Fatma , Bougatef Hajer , Capitani Federica , Ben Amor Ikram , Koubaa Imed , Gargouri Jalel , Maccari Francesca , Mantovani Veronica , Galeotti Fabio , Volpi Nicola , Bougatef Ali
Published: November 2018

Chondroitin sulfate/dermatan sulfate (CS/DS) was extracted from Atlantic bluefin tuna (Thunnus thynnus) skin (SGAT) and was purified and characterized.
Protective desilication of highly siliceous H-ZSM-5 by sole tetraethylammonium hydroxide for the methanol to propylene (MTP) reaction
Authors: Zhang Yunpeng , Li Minggang , Xing Enhui , Luo Yibin , Shu Xingtian
Published: November 2018

Protective desilication of highly siliceous H-ZSM-5 was effectively realized by dissolution and recrystallization in tetraethylammonium hydroxide (TEAOH) solution.
Dissipative particle dynamics simulation of multicompartment micelle nanoreactor with channel for reactants
Authors: Lee Seung Min , Bond Nicholas , Callaway Connor , Clark Benjamin , Farmer Emily , Mallard MacKensie , Jang Seung Soon
Published: November 2018

The structural variation of multicompartment micelles is investigated using a dissipative particle dynamics simulation method for nano-reactor application.
Platelet aggregation induced by polystyrene and platinum nanoparticles is dependent on surface area
Authors: Zia Fatima , Kendall Michaela , Watson Steve P. , Mendes Paula M.
Published: November 2018

Nanoparticles are key components underlying recent technological advances in various industrial and medical fields, and thus understanding their mode of interaction with biological systems is essential.
Polyvinylchloride-derived N, S co-doped carbon as an efficient sulfur host for high-performance Li–S batteries
Authors: Hu Cejun , Chang Yingna , Chen Ruida , Yang Jijin , Xie Tianhui , Chang Zheng , Zhang Guoxin , Liu Wen , Sun Xiaoming
Published: November 2018

The intrinsic polysulfide shuttle in lithium–sulfur (Li–S) batteries have significantly limited their practical applications.
Production of cyclopentanone from furfural over Ru/C with Al11.6PO23.7 and application in the synthesis of diesel range alkanes
Authors: Shen Tao , Hu Ruijia , Zhu Chenjie , Li Ming , Zhuang Wei , Tang Chenglun , Ying Hanjie
Published: November 2018

Cyclopentanone as the substrate for the synthesis of jet fuel range cyclic alkanes can be prepared through the cyclopentenone route under mild conditions and catalyzed by Ru/C with Al11.6PO23.7 from furfural.
Stabilizing nickel-rich layered oxide cathodes by magnesium doping for rechargeable lithium-ion batteries
Authors: Li Hang , Zhou Pengfei , Liu Fangming , Li Haixia , Cheng Fangyi , Chen Jun
Published: November 2018

Magnesium doping in a high-capacity Ni-rich cathode suppresses cation mixing and transition-metal migration, leading to remarkable structural stability and cycling performance.
Near wall dynamics of a spherical particle in crowded suspensions of colloidal rods – dynamic information from TIRM revisited
Authors: De Sio Silvia , July Christoph , Dhont Jan K. G. , Lang Peter R.
Published: November 2018

We performed total internal reflection microscopy (TIRM) experiments to determine the depletion potentials between probe spheres and a flat glass wall, induced by rod-shaped colloids (fd-virus), and we suggest a new approach to study the spatially resolved dynamics of the probe spheres.
Aqueous “polysulfide-ene” polymerization for sulfur-rich nanoparticles and their use in heavy metal ion remediation
Authors: Shin Hyuksoo , Kim Jihee , Kim Dowan , Nguyen Viet Huu , Lee Sangwook , Han Seunghee , Lim Jeewoo , Char Kookheon
Published: November 2018

Thiol-functionalized polymer nanoparticles demonstrated well-defined mercury ion uptake kinetics, along with a very high mercury ion capture capacity.
Synthesis and functionalisation of spherical meso-, hybrid meso/macro- and macro-porous cellular silica foam materials with regulated pore sizes for CO2 capture
Authors: Sun Yuan , Liu Xin , Sun Chenggong , Al-Sarraf Waleed , Foo Khai Zhen , Meng Yang , Lee Stevens , Wang Wenlong , Liu Hao
Published: November 2018

Porous cellular silica materials with nano-foamed wall structures have been developed for preparing supported polyamines for CO2 capture, with CO2 capacities reaching 5.85 mmol CO2 per g PEI-600, 6.44 mmol per g PEI-600/TEPA and 4.4 mmol per g PEI-60 000.
Stoichiometry-dependent local instability in MAPbI3perovskite materials and devices
Authors: Kumar Vikas , Barbé Jérémy , Schmidt Whitney L. , Tsevas Konstantinos , Ozkan Buse , Handley Christopher M. , Freeman Colin L. , Sinclair Derek C. , Reaney Ian M. , Tsoi Wing C. , Dunbar Alan , Rodenburg Cornelia
Published: November 2018

Organometallic perovskite materials based on MAPbI3achieve photovoltaic efficiencies as high as 22% for solar cells; however, the long-term stability of these perovskite materials is still a hurdle for applications.
Direct microencapsulation of pure polyamine by integrating microfluidic emulsion and interfacial polymerization for practical self-healing materials
Authors: Zhang He , Zhang Xin , Bao Chenlu , Li Xin , Sun Dawei , Duan Fei , Friedrich Klaus , Yang Jinglei
Published: November 2018

Robust pure polyamine microcapsules were directly synthesized by integrating microfluidic and interfacial polymerization for autonomous practical self-healing epoxy with full recoverability.
Methane dry reforming catalyst prepared by the co-deflagration of high-nitrogen energetic complexes
Authors: Dahan Moran , Komarala Eswaravara , Fadeev Ludmila , Chinnam Ajay K. , Shlomovich Avital , Lipstman Sophia , Padi Siva P. , Haustein Herman , Gozin Michael , Rosen Brian A.
Published: November 2018

Methane dry reforming presents a unique opportunity to simultaneously consume both methane and carbon dioxide and generate from them clean-burning synthetic fuels for mobile energy applications.
Effects of temperature and coating speed on the morphology of solution-sheared halide perovskite thin-films
Authors: Kim Min Kyu , Lee Hyeon Seok , Pae Seong Ryul , Kim Dong-Jun , Lee Jung-Yong , Gereige Issam , Park Steve , Shin Byungha
Published: November 2018

Different phases of morphology form with a delicate balance between the supersaturation rate and rate of solution supply to the meniscus.
Energy-efficient 1.67 V single- and 0.90 V dual-electrolyte based overall water-electrolysis devices enabled by a ZIF-L derived acid–base bifunctional cobalt phosphide nanoarray
Authors: Zhu Wenxin , Zhang Wentao , Li Yinge , Yue Zhihao , Ren Meirong , Zhang Yi , Saleh Neveen M. , Wang Jianlong
Published: November 2018

Energy-efficient 1.67 V single- and 0.90 V dual-electrolyte based overall water-electrolysis devices enabled by a ZIF-L derived acid–base bifunctional cobalt phosphide nanoarray.
Donor polymer based on alkylthiophene side chains for efficient non-fullerene organic solar cells: insights into fluorination and side chain effects on polymer aggregation and blend morphology
Authors: Liu Jing , Ma Lik-Kuen , Li Zhengke , Hu Huawei , Sheong Fu Kit , Zhang Guangye , Ade Harald , Yan He
Published: November 2018

The synergistic effects of overfluorination and alkylthiophene side chain strategies led to 10.60% efficiency for non-fullerene organic solar cells.
An advanced sandwich-type architecture of MnCo2O4@N–C@MnO2 as an efficient electrode material for a high-energy density hybrid asymmetric solid-state supercapacitor
Authors: Shrestha Khem Raj , Kandula Syam , Rajeshkhanna G. , Srivastava Manish , Kim Nam Hoon , Lee Joong Hee
Published: November 2018

A thin layer of N–C sandwiched between an electroactive MnCo2O4 core and MnO2 shell results in sophisticated, robust core@sandwich@shell as a highly efficient energy storage material.
Compaction of a zirconium metal–organic framework (UiO-66) for high density hydrogen storage applications
Authors: Bambalaza Sonwabo E. , Langmi Henrietta W. , Mokaya Robert , Musyoka Nicholas M. , Ren Jianwei , Khotseng Lindiwe E.
Published: November 2018

Compaction of powdered UiO-66 MOF results in improved volumetric hydrogen capacity without compromising the gravimetric hydrogen uptake.
Biosynthetic calcium-doped biosilica with multiple hemostatic properties for hemorrhage control
Authors: Li Jing , Han Jichang , Sun Qingjie , Wang Yanan , Mu Yuzhi , Zhang Kaichao , Dou Xiaoyu , Kong Ming , Chen Xiguang , Feng Chao
Published: November 2018

A sustainable and environmentally friendly biomineralization strategy was developed to obtain calcium-doped biosilica with excellent hemostatic properties and biocompatibility.
Synthesis of Bi2−2xSb2xS3 (0 ≤ x ≤ 1) solid solutions from solventless thermolysis of metal xanthate precursors
Authors: Alqahtani Tahani , Khan Malik Dilshad , Kelly Daniel J. , Haigh Sarah J. , Lewis David J. , O’Brien Paul
Published: November 2018

Tris(O-ethylxanthate)bismuth(iii) (1) and tris(O-ethylxanthate)antimony(iii) (2) were synthesized and used as precursors for the preparation of Bi2−2xSb2xS3 alloys (x = 0, 0.2, 0.4, 0.6, 0.8 and 1) using melt reactions.
Nanoscale engineering of ionic environment for efficient mid-infrared luminescenceviaelectric polarization
Authors: Cai Yangjian , Bai Gongxun , Tian Ying , Huang Feifei , Xu Shiqing , Zhang Junjie
Published: November 2018

This work presents for the first time the efficient tuning of mid-infrared photoluminescence by nanoscale engineering of the ionic environment.
A new cross-linkable 9,10-diphenylanthracene derivative as a wide bandgap host for solution-processed organic light-emitting diodes
Authors: Hallani Rawad K. , Fallah Hamidabadi Vahid , Huckaba Aron Joel , Galliani Gianmarco , Babaei Azin , La-Placa Maria-Grazia , Bahari Ali , McCulloch Iain , Nazeeruddin Mohammad Khaja , Sessolo Michele , Bolink Henk J.
Published: November 2018

We present a cross-linkable wide bandgap host based on 9-(4-(10-phenylanthracene-9-yl)phenyl)-9H-carbazole.
Carbohydrate response element binding protein (ChREBP) modulates the inflammatory response of mesangial cells in response to glucose
Authors: Chen Yan , Wang Yan-Jun , Zhao Ying , Wang Jin-Cheng
Published: November 2018

Diabetic nephropathy (DN) is one of the most devastating complications of diabetes mellitus. Carbohydrate response element binding protein (ChREBP) is a basic helix–loop–helix leucine zipper transcription factor that primarily mediates glucose homeostasis in the body. The present study investigated the role of ChREBP in the pathogenesis of DN. The expression of ChREBP was detected in patients with type 2 diabetes mellitus (T2DM), diabetic mice, and mesangial cells. ELISA was used to measure cytokine production in mesangial cells. Flow cytometry analysis was performed to detect the apoptosis of mesangial cells in the presence of high glucose. The expression levels of ChREBP and several cytokines (TNF-α, IL-1β, and IL-6) were up-regulated in T2DM patients. The mRNA and protein levels of ChREBP were also significantly elevated in the kidneys of diabetic mice. Moreover, glucose treatment promoted mRNA levels of TNF-α, IL-1β, and IL-6 in mesangial cells. Glucose stimulation induced significant apoptosis of SV40 MES 13 cells. In addition, transfection with ChREBP siRNA significantly inhibited ChREBP expression. Consequently, the inflammatory responses and apoptosis were inhibited in SV40 MES 13 cells. These results demonstrated that ChREBP could mediate the inflammatory response and apoptosis of mesangial cells, suggesting that ChREBP may be involved in the pathogenesis of DN.
Label-free imaging of neurotransmitters in live brain tissue by multi-photon ultraviolet microscopy
Authors: Maity Barun Kumar , Maiti Sudipta
Published: November 2018

Visualizing small biomolecules in living cells remains a difficult challenge. Neurotransmitters provide one of the most frustrating examples of this difficulty, as our understanding of signaling in the brain critically depends on our ability to follow the neurotransmitter traffic. Last two decades have seen considerable progress in probing some of the neurotransmitters, e.g. by using false neurotransmitter mimics, chemical labeling techniques, or direct fluorescence imaging. Direct imaging harnesses the weak UV fluorescence of monoamines, which are some of the most important neurotransmitters controlling mood, memory, appetite, and learning. Here we describe the progress in imaging of these molecules using the least toxic direct excitation route found so far, namely multi-photon (MP) imaging. MP imaging of serotonin, and more recently that of dopamine, has allowed researchers to determine the location of the vesicles, follow their intracellular dynamics, probe their content, and monitor their release. Recent developments have even allowed ratiometric quantitation of the vesicular content. This review shows that MP ultraviolet (MP-UV) microscopy is an effective but underutilized method for imaging monoamine neurotransmitters in neurones and brain tissue.
Early Motor and Communicative Development in Infants With an Older Sibling With Autism Spectrum Disorder
Authors: Iverson Jana M.
Published: November 2018

Purpose

A recent approach to identifying early markers of risk for autism spectrum disorder (ASD) has been to study infants who have an older sibling with ASD. These infants are at heightened risk (HR) for ASD and for other developmental difficulties, and even those who do not receive an eventual ASD diagnosis manifest a high degree of variability in trajectories of development. The primary goal of this review is to summarize findings from research on early motor and communicative development in these HR infants.

Method

This review focuses on 2 lines of inquiry. The first assesses whether delays and atypicalities in early motor abilities and in the development of early communication provide an index of eventual ASD diagnosis. The second asks whether such delays also influence infants' interactions with objects and people in ways that exert far-reaching, cascading effects on development.

Results

HR infants who do and who do not receive a diagnosis of ASD vary widely in motor and communicative development. In addition, variation in infant motor and communicative development appears to have cascading effects on development, both on the emergence of behavior in other domains and on the broader learning environment.

Conclusions

Advances in communicative and language development are supported by advances in motor skill. When these advances are slowed and/or when new skills are not consolidated and remain challenging for the infant, the enhanced potential for exploration afforded by new abilities and the concomitant increase in opportunities for learning are reduced. Improving our understanding of communicative delays of the sort observed in ASD and developing effective intervention methods requires going beyond the individual to consider the constant, complex interplay between developing communicators and their environments.

Presentation Video

https://doi.org/10.23641/asha.7299308
Modeling ionized gas in low-metallicity environments: the Local Group dwarf galaxy IC 10
Authors: Polles F. L. , Madden S. C. , Lebouteiller V. , Cormier D. , Abel N. , Galliano F. , Hony S. , Karczewski O. Ł. , Lee M.-Y. , Chevance M. , Galametz M. , Lianou S.
Published: November 2018

Context. Star formation activity is an important driver of galaxy evolution and is influenced by the physical properties of the interstellar medium. Dwarf galaxies allow us to understand how the propagation of radiation and the physical conditions of the different ISM phases are affected by the low-metallicity environment.

Aims. Our objective is to investigate the physical properties of the ionized gas of the low-metallicity dwarf galaxy, IC 10, at various spatial scales: from individual H II regions to the entire galaxy scale and examine whether diagnostics for integrated measurements introduce bias in the results.

Methods. We modeled the ionized gas combining the mid- and far-infrared fine-structure cooling lines observed with Spitzer/IRS and Herschel/PACS, with the photoionization code CLOUDY. The free parameters of the models are the age of the stellar cluster, the density, and the ionization parameter of the ionized gas as well as the depth of the cloud. The latter is used to investigate the leakage of the ionizing photons from the analyzed regions of IC 10. We investigated H II regions in the main star-forming body, on scales of ~25 pc, three in the main star-forming region in the center of the galaxy and two on the first arc. We then considered larger sizes on the scale of ~200 pc.

Results. Most clumps have almost-identical properties, density ~102–102.6 cm−3, ionization parameter between 10−2.2 and 10−1.6, and age of the stellar cluster ~5.5 Myr. All of them are matter-bounded regions, allowing ionizing photons to leak. The relatively uniform physical properties of the clumps suggest a common origin for their star formation activity, which could be related to the feedback from stellar winds or supernovae of a previous generation of stars. The properties derived for ~200 pc size “zones” have similar properties as the H II regions they encompass, but with the larger regions tending to be more radiation bounded. Finally, we investigated the fraction of [CII] 157.7 μm, [SiII] 34.8 μm and [FeII] 25.9 μm emission arising from the ionized gas phase and we find that most of the emission originates from the neutral gas, not from the ionized gas.
The population of hot subdwarf stars studied with Gaia
Authors: Geier S. , Raddi R. , Gentile Fusillo N. P. , Marsh T. R.
Published: November 2018

Based on data from the ESA Gaia Data Release 2 (DR2) and several ground-based, multi-band photometry surveys we have compiled an all-sky catalogue of 39 800 hot subluminous star candidates selected in Gaia DR2 by means of colour, absolute magnitude, and reduced proper motion cuts. We expect the majority of the candidates to be hot subdwarf stars of spectral type B and O, followed by blue horizontal branch stars of late B-type (HBB), hot post-AGB stars, and central stars of planetary nebulae. The contamination by cooler stars should be about 10%. The catalogue is magnitude limited to Gaia G < 19 mag and covers the whole sky. Except within the Galactic plane and LMC/SMC regions, we expect the catalogue to be almost complete up to about 1.5 kpc. The main purpose of this catalogue is to serve as input target list for the large-scale photometric and spectroscopic surveys which are ongoing or scheduled to start in the coming years. In the long run, securing a statistically significant sample of spectroscopically confirmed hot subluminous stars is key to advance towards a more detailed understanding of the latest stages of stellar evolution for single and binary stars.
Selection functions of large spectroscopic surveys
Authors: Mints Alexey , Hekker Saskia
Published: November 2018

Context. Large spectroscopic surveys open the way to explore our Galaxy. In order to use the data from these surveys to understand the Galactic stellar population, we need to be sure that stars contained in a survey are a representative sub-set of the underlying population. Without the selection function taken into account, the results might reflect the properties of the selection function rather than those of the underlying stellar population.

Aims. In this work, we introduce a method to estimate the selection function for a given spectroscopic survey. We aim to apply this method to a large sample of public spectroscopic surveys.

Methods. We have applied a median division binning algorithm to bin observed stars in the colour–magnitude space. This approach produces lower uncertainties and lower biases of the selection function estimate as compared to traditionally used 2D-histograms. We ran a set of simulations to verify the method and calibrate the one free parameter it contains. These simulations allow us to test the precision and accuracy of the method.

Results. We produce and publish estimated values and uncertainties of selection functions for a large sample of public spectroscopic surveys. We publicly release the code used to produce the selection function estimates.

Conclusions. The effect of the selection function on distance modulus and metallicity distributions of stars in surveys is important for surveys with small and largely inhomogeneous spatial coverage. For surveys with contiguous spatial coverage the effect of the selection function is almost negligible.
Properties of the inner penumbral boundary and temporal evolution of a decaying sunspot
Authors: Benko M. , González Manrique S. J. , Balthasar H. , Gömöry P. , Kuckein C. , Jurčák J.
Published: November 2018

Context. It has been empirically determined that the umbra-penumbra boundaries of stable sunspots are characterized by a constant value of the vertical magnetic field.

Aims. We analyzed the evolution of the photospheric magnetic field properties of a decaying sunspot belonging to NOAA 11277 between August 28–September 3, 2011. The observations were acquired with the spectropolarimeter on-board of the Hinode satellite. We aim to prove the validity of the constant vertical magnetic-field boundary between the umbra and penumbra in decaying sunspots.

Methods. A spectral-line inversion technique was used to infer the magnetic field vector from the full-Stokes profiles. In total, eight maps were inverted and the variation of the magnetic properties in time were quantified using linear or quadratic fits.

Results. We find a linear decay of the umbral vertical magnetic field, magnetic flux, and area. The penumbra showed a linear increase of the vertical magnetic field and a sharp decay of the magnetic flux. In addition, the penumbral area quadratically decayed. The vertical component of the magnetic field is weaker on the umbra-penumbra boundary of the studied decaying sunspot compared to stable sunspots. Its value seem to be steadily decreasing during the decay phase. Moreover, at any time of the sunspot decay shown, the inner penumbra boundary does not match with a constant value of the vertical magnetic field, contrary to what is seen in stable sunspots.

Conclusions. During the decaying phase of the studied sunspot, the umbra does not have a sufficiently strong vertical component of the magnetic field and is thus unstable and prone to be disintegrated by convection or magnetic diffusion. No constant value of the vertical magnetic field is found for the inner penumbral boundary.
La myopathie à agrégats tubulaires et le syndrome de Stormorken
Authors: Böhm Johann , Laporte Jocelyn
Published: November 2018

Le calcium est un régulateur essentiel pour un grand nombre de fonctions cellulaires, et une perturbation de l’homéostasie calcique peut sévèrement troubler la physiologie de différents tissus. CASQ1, STIM1, et ORAI1 codent pour des facteurs clés contrôlant les flux de calcium, et des mutations de ces gènes sont à l’origine de la myopathie à agrégats tubulaires et du syndrome de Stormorken. Ces deux maladies forment un continuum clinique regroupant faiblesse musculaire, myosis, thrombopénie, hyposplénisme, ichthyose, dyslexie et petite taille.
Optimal compromise between incompatible conditional probability distributions, with application to Objective Bayesian Kriging
Authors: Muré Joseph
Published: November 2018

Models are often defined through conditional rather than joint distributions, but it can be difficult to check whether the conditional distributions are compatible,i.e.whether there exists a joint probability distribution which generates them. When they are compatible, a Gibbs sampler can be used to sample from this joint distribution. When they are not, the Gibbs sampling algorithm may still be applied, resulting in a “pseudo-Gibbs sampler”. We show its stationary probability distribution to be the optimal compromise between the conditional distributions, in the sense that it minimizes a mean squared misfit between them and its own conditional distributions. This allows us to perform Objective Bayesian analysis of correlation parameters in Kriging models by using univariate conditional Jeffreys-rule posterior distributions instead of the widely used multivariate Jeffreys-rule posterior. This strategy makes the full-Bayesian procedure tractable. Numerical examples show it has near-optimal frequentist performance in terms of prediction interval coverage.
Natural radioactivity measurements and external dose estimation by car-borne survey in Douala city, Cameroon
Authors: Takoukam Soh S.D. , Saïdou  , Hosoda M. , Ndjana Nkoulou II J.E. , Akata N. , Bouba O. , Tokonami S.
Published: November 2018

A car-borne survey was carried out in Douala, the largest city in Cameroon to make a detailed distribution map of the absorbed dose rate in the city, to locate the high natural radiation areas useful later to carry out indoor radon, thoron, and thoron progeny measurements. Gamma-ray dose rates were measured using 3-in × 3-in NaI(Tl) detector. Activity concentrations of238U,232Th and40K in soil from Douala city were determined by two methods: the first, usingin situgamma spectrometry and the second, at the laboratory using a NaI(Tl) detector. A heterogeneous distribution of absorbed dose rates in air was observed on the dose rate distribution map, and varies from 29 to 86 nGy h−1with an average of 50 nGy h−1, lower than the world average value of 59 nGy h−1. The activity concentrations with NaI(Tl) detector varied from 18 to 47 Bq kg−1for238U, 21 to 54 Bq kg−1for232Th, and 10 to 410 Bq kg−1for40K with averages of 29, 38, and 202 Bq kg−1respectively, forin situmeasurements. They vary between 29–98 Bq kg−1for238U, 29–92 Bq kg−1for232Th, and 40 to 79 Bq kg−1for40K, with averages of 60, 57, and 56 Bq kg−1respectively for soil samples collected at Douala III subdivision. The highest value of the annual effective dose forin situmeasurements by car was observed at Ndogbong and was found to be 0.7 mSv y−1, higher than the world average value of 0.5 mSv y−1.
Whole-Body CT in Multiple Trauma Patients: Clinically Adapted Usage of Differently Weighted CT Protocols
Authors: Reske Stefan , Braunschweig Rainer , Reske Andreas , Loose Reinhard , Wucherer Michael
Published: November 2018

Purpose Whole-body CT (wbCT) has been established as an internationally accepted diagnostic modality in multiple trauma. Until 2011, a uniform CT scanning protocol was used for all multiple trauma patients (pat.) at our hospital (OLD protocol = OP). In 2011, 2 new differently weighted protocols were introduced: TIME protocol (TP) for hemodynamically unstable pat. and DOSE protocol (DP) for pat. with stable vital parameters. The aim of this study was to compare the original “One-fits-all-concept” with the new, clinically oriented approach to wbCT.

Materials and Methods This study retrospectively evaluated 3 distinct wbCT protocols, looking at automatic exposure control variation (AEC; OP/TP) and arm positioning close to the body/overhead (TP/DP). The analysis included waist circumference (WC, cm), injury severity score (ISS), examination time (ET, min), image noise (IN), and effective dose (E, mSv). Normality of distribution was assessed with the Kolmogorov-Smirnov test. Data are given as median and range. Test of significance with Kruskal-Wallis test or Mann-Whitney-U-test. Level of significance: 0.05.

Results 308 pat. were included in the study (77 % m; age: 46 a, 18 – 90 a; WC: 93 cm, 66 – 145 cm). ISS was 14 (OP; n = 104; 0 – 75), 18 (TP; n = 102; 0 – 75) and 9 (DP; n = 102; 0 – 50). ET was 3.9 min (OP; 3.3 – 5.6 min), 4.1 min (TP; 2.8 – 7.2 min) and 7.7 min (DP; 6 – 10 min). IN showed no significant differences when comparing OP/TP but was significantly reduced in DP. For a wbCT (vertex to ischium), E could be reduced from 49.7 mSv to 35.4 mSv by optimizing AEC (OP/TP). Through the overhead repositioning of the arms in DP, a further reduction to 28.2 mSv was achieved.

Conclusion AEC and arm repositioning have a crucial influence on image quality and dose. The presented clinical approach is superior to the original concept.

Key Points:

Citation Format
Impact Loading During Distracted Running Before and After Auditory Gait Retraining
Authors: Ching Eric , An Winko , Au Ivan , Zhang Janet , Chan Zoe , Shum Gary , Cheung Roy
Published: November 2018

Visual feedback gait retraining has been reported to successfully reduce impact loading in runners, even when the runners were distracted. However, auditory feedback is more feasible in real life application. Hence, this study compared the peak positive acceleration (PPA), vertical average (VALR) and instantaneous (VILR) loading rate during distracted running before and after a course of auditory feedback gait retraining in 16 runners. The runners were asked to land with softer footfalls with and without auditory feedback. Low or high sound pitch was generated according to the impact of particular footfall, when compared with the preset target. Runners then received a course of auditory gait retraining, and after the gait retraining, runners completed a reassessment. Runners before gait retraining exhibited lower PPA, VALR and VILR with augmented auditory feedback (p<0.049). We found a reduction in PPA, VALR and VILR after gait retraining, regardless of the presence of feedback (p<0.018). However, runners after gait retraining did not demonstrate further reduction in PPA and VALR with auditory feedback (p>0.104). A small effect of auditory feedback on VILR in runners after gait retraining was observed (p=0.032). Real time auditory feedback gait retraining is effective in impact loading reduction, even when the runners were distracted.
Circulating Inflammatory Cytokine Responses to Endurance Exercise in Female Rowers
Authors: Jürimäe Jaak , Vaiksaar Sille , Purge Priit
Published: November 2018

This investigation examined the effects of acute rowing exercise on a panel of 12 different inflammatory cytokines. Fifteen female rowers (18.3±1.6 yrs; 172.0±5.0 cm; 67.5±8.8 kg; maximal oxygen consumption [VO2max]: 47.2±7.9 ml.min.−1kg−1) completed a 1-h endurance exercise (distance: 12.1±1.1 km; energy expenditure [EE]: 639±69 kcal; heart rate: 151±7 beats.min−1; intensity: 79.6±3.5% of the second ventilatory turn point). Venous blood samples were analysed for interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), IL-1α, IL-1β, monocyte chemoattractant protein-1 (MCP-1) and epidermal growth factor (EGF) concentrations. Rowing exercise resulted increment (P<0.05) in IL-6, IL-8, VEGF and MCP-1. Exercise metabolic demand variables such as rating of perceived exertion (r=0.61), distance covered (r=0.60) and EE (r=0.57) were related (P<0.05) to changes in VEGF concentration. Cardiorespiratory fitness as measured by VO2max was correlated with changes in IL-6 (r=–0.55; P<0.05) level. In conclusion, acute exercise-induced inflammatory reaction was induced by a significant increase in IL-6, IL-8, VEGF and MCP-1 concentrations. Variance in exercise-induced increases in inflammatory cytokines in response to prolonged endurance exercise was characterised by exercise metabolic demand and cardiorespiratory fitness measures in female rowers.
Resumen guía de práctica clínica para la valoración urológica pretrasplante renal
Authors: Riatiga Ibáñez Diego , Cubillos Jorge , Tovar Roa Verónica , Fajardo Cediel William , García Perdomo Herney
Published: November 2018

En Colombia actualmente, se ha visto un aumento significativo en el número de pacientes con enfermedad renal crónica terminal (ERC-T) llegando a 23.914 en 2014 según las estadísticas del instituto nacional de salud, lo que supone un aumento en el número de trasplantes, aumentando de un 12,5% en 2008 al 18% en 2014 del total de pacientes con ERC-T. Teniendo en cuenta que el trasplante renal se ha consolidado como la mejor opción terapéutica en esos pacientes, es de suma importancia unificar criterios y conceptos basados en la mejor evidencia científica disponible para reducir complicaciones y efectos nocivos derivados de esta terapia, razón por la cual se ha creado esta guía.
Glande Peneano – Teoría Integral y su Relación con la Triada Disfuncional (Glande Frío, Blando o Doloroso)
Authors: Uribe Arcila Juan
Published: November 2018

El glande peneano forma parte de un ingenioso diseño evolutivo que convirtió el pene en una compleja maquina hidráulica bicameral para la intromisión exitosa en la vagina. El objetivo del glande es tener un extremo blando, recubierto con una piel de terminales altamente sensitivas que forma parte de un tercer cuerpo cilíndrico, que debe colaborar en la tumescencia peneana sin interferir ni en la eyección del semen, ni en la evacuación de la orina, al estar las funciones reproductivas y urinarias compartidas por el mismo órgano. Los cuerpos cavernosos y el esponjoso, incluyendo el glande, comparten anatomía y fisiología en lo referente a trabéculas, túnica albugínea y llenado de sangre, pero no son idénticos en función, por lo que conceptos como rigidez axial, distribución de receptores o venoclusión varían de una a otra cámara. Adicionalmente a su discreta colaboración en la erección, el glande es el origen del llamado reflejo eyaculatorio, que es básico en el proceso sexual humano. La disfunción de esa porción terminal, incluye tres situaciones patológicas que son el glande frío, blando o doloroso, con etiología común, relacionada con factores como trauma, disfunción eréctil o cirugías tales como prostatectomía radical o cirugía uretral, con muy pocos tratamientos específicos disponibles en la actualidad y que sin embargo deberán ir mejorando por la inusitada frecuencia de esos padecimientos.
Prevalencia de Eventos Cardiocerebrovasculares en Pacientes con Cáncer de Próstata en Manejo con Bloqueo Androgénico con Análogo de GNRH
Authors: Poveda José , González Cesar , Quiroga William , Zapata Margarita , Baena Sebastián
Published: November 2018

Objetivo Determinar la prevalencia de eventos cardiocerebrovasculares en pacientes con cáncer de próstata que son manejados con bloqueo hormonal, con análogo de la GNRH.

Materiales y Métodos Se realizó un estudio de corte transversal, en pacientes con cáncer de próstata que fueron manejados con bloqueo hormonal con análogo de la GNRH, con un mínimo de seguimiento de 2 años, entre los años 2004 y 2014. Paciente con eventos que acaecieron en el primer año de observación, fueron excluidos. Se evaluaron las comorbilidades de los pacientes y se clasificaron en diferentes grupos de riesgo, según el índice de comorbilidades ACE27. Se determinó la prevalencia de eventos cardiovasculares definidos como un episodio de infarto agudo de miocardio, de angina y de eventos cerebrovasculares durante la observación. Se comparó la prevalencia de acuerdo al subgrupo de riesgo ACE27.

Resultados Se incluyeron 281 pacientes. La comorbilidad más común fue la hipertensión arterial con un 45% y por último la diabetes mellitus con un 17%. La prevalencia de eventos cardiovasculares y cerebrovasculares en la población general fue del 7,5% para cada evento. Se clasificaron los pacientes según el índice de comorbilidades ACE-27 tendiendo el 39% de los pacientes un índice de comorbilidad bajo y el 7% alto. La prevalencia de eventos cardiocerebrovasculares varía desde el 5% en bajo riesgo, hasta el 25% en grupo de alto riesgo.

Conclusiones La prevalencia de eventos cardiocerebrovasculares fue del 7,5% en la población de estudio. En el grupo de alto riesgo ACE27 con el uso de análogo de GNRH, se determinó una mayor prevalencia de eventos cardiocerebrovasculares.
Eficacia y seguridad del dietiletilbestrol, en el tratamiento del cáncer de próstata resistente a la castración
Authors: Gómez Meza Jorge , Varela Rodolfo , Ramírez Angie
Published: November 2018

Introducción y objetivos Existen múltiples opciones de tratamiento en pacientes con cáncer de próstata resistente a la castración, entre ellas el Dietilestilbestrol (DES) sin embargo, su uso es controversial. Este estudio tiene como objetivo determinar la eficacia y seguridad del DES, en el tratamiento de pacientes con cáncer de próstata resistente a la castración en nuestra población.

Métodos y Materiales Se realizó un estudio de corte transversal, incluyendo los pacientes con cáncer de próstata resistente a la castración que recibieron tratamiento con DES. Se realizó un análisis demográfico, bivariado, tomando como desenlace la respuesta del PSA (Ausente, Completa o Parcial), el tiempo medio de progresión del PSA y la presencia de eventos adversos asociados al medicamento.

Resultados  Noventa y un pacientes incluidos al final del estudio. La distribución de respuesta del PSA fue así: Respuesta en 57 (63,7%) pacientes, (Completa 28% - 31,1% y parcial 29% - 32,2%). Ausente en 33 (36,7%) pacientes. El análisis bivariado no evidenció asociación entre las variables y los desenlaces propuestos. El tiempo medio de progresión del PSA fue de 10,43 meses (Log-rank p = 0.001), no se encontraron diferencias estadísticamente significativas para el tiempo medio a progresión en asociación con la respuesta al PSA (respuesta o ausente y la presencia de enfermedad metastásica), Log-rank p = 0,789, Log-rank p = 0,218, Log-rank p = 0,780 respectivamente. La tasa de complicaciones asociadas a DES fue del 4,4% y correspondió en todos los casos a trombosis venosa profunda.

Conclusiones El DES en pacientes con cáncer de próstata resistente a la castración continúa siendo una herramienta de tratamiento eficaz y con baja tasa de eventos adversos en nuestra población.
Indicaciones actuales de colocación de stent uretral Allium – revisión de la literatura
Authors: Henao Matilde , Gaviria Federico
Published: November 2018

La estrechez de la uretra es una patología con una prevalencia del 0,6% de la población El estándar de oro establecido para su manejo es la uretroplastia con tasas de éxito variables de hasta el 90% al 95%.

El stent uretral surgió en 1988 fabricado con malla de acero inoxidable. Los resultados obtenidos demostraron las complicaciones severas de su implantación. En el 2008 se introdujo el stent Allium producido en Israel con propiedades diferentes como elasticidad y flexibilidad. Puede utilizarse en diferentes entidades como estrechez de uretra bulbar, hiperplasia de próstata y la estenosis de la unión uretrovesical. Recientemente este Stent se está comercializando en Colombia, por lo cual consideramos importante revisar la literatura mundial, las complicaciones e indicaciones reales y así intentar evitar el uso inapropiado de esos dispositivos.

Realizamos una Revisión de la literatura en PubMed y ClinicalKey incluyendo los términos, “Stent”, “Allium” y “Urethral”, incluyendo articulos en inglés y en español. Se encontraron 4 artículos retrospectivos en poblaciones heterogéneas con tasas de éxito inferiores a la cirugía reconstructiva. No se encontraron estudios comparativos.

Las indicaciones actuales para colocar un stent uretral podrían ser pacientes en quienes no se puede realizar uretroplastia, o en quienes el manejo endoscópico de la uretra posterior no haya sido efectivo. También puede ser una alternativa para pacientes con sonda vesical permanente por hiperplasia prostática no aptos para cirugía.