bluuebunny/crossref_metadata_2025 huggingface dataset:
On the variational treatment of a class of double-well oscillators
Authors: Fernández Francisco M. , Garcia Javier
Published: September 2023

We compare the well known Rayleigh-Ritz variational method (RRVM) with a recently proposed approach based on supersymmetric quantum mechanics and the Gram-Schmidt orthogonalization method (SSQMGS). We apply both procedures to a particular class of double-well harmonic oscil-lators that had been conveniently chosen for the application of the latter approach. The RRVM eigenvalues converge smoothly from above providing much more accurate results with less computational effort. Present results show that the unproved SSQMGS upper bounds do not hold.
Neonatal jaundice detection in low-resource Mexican settings: possibilities and barriers for innovation with mobile health
Authors: Jiménez-Díaz Gabriela , Aune Anders , Elizarrarás-Rivas Jesús , Gierman Lobke Marijn , Keitsch Martina , Marcuzzi Anna , Infanti Jennifer Jean
Published: September 2023

Background: Neonatal jaundice is a common condition that can lead to brain damage and disabilities when severe cases go undetected. Low- and middle-income countries often lack accurate methods for detecting neonatal jaundice and rely on visual assessment, resulting in a higher incidence of adverse consequences. Picterus Jaundice Pro (Picterus JP), an easy-to-use and affordable smartphone-based screening device for the condition, has demonstrated higher accuracy than visual assessment in Norwegian, Philippine and Mexican newborns. This study aimed to identify the barriers and facilitators to implementing Picterus JP in public health services in low-income settings in Mexico by exploring the current process of neonatal jaundice detection and stakeholders’ perspectives in that context.
Methods:Qualitative data collection techniques, including one focus group, 15 semi-structured interviews and four observations, were employed in urban and rural health facilities in Oaxaca, Mexico. The participants included medical doctors, nurses and health administrators. The data were analysed by thematic analysis guided by the Consolidated Framework for Implementation Research.
Results: The analysis yielded four main themes: (I) the current state of neonatal care and NNJ detection, (II) the needs and desires for enhancing NNJ detection, (III) the barriers and facilitators to implementing Picterus JP in the health system and (IV) HCWs’ expectations of Picterus JP.
The findings identify deficiencies in the current neonatal jaundice detection process and the participants’ desire for a more accurate method. Picterus JP was perceived as easy to use, useful and compatible with the work routine, but barriers to adoption were identified, including internet deficiencies and costs.
Conclusions: The introduction of Picterus JP as a supporting tool to screen for neonatal jaundice is promising but contextual barriers in the setting must be addressed for successful implementation. There is also an opportunity to optimise visual assessment to improve detection of neonatal jaundice.
Some thoughts on modelling abrasion-corrosion: wear by hard particles in corrosive environments
Authors: Jiang Jiaren (Jimmy) , Islam MD Aminul , Xie Yongsong , Stack Margaret M
Published: September 2023

Wear by hard particles can involve abrasion or erosion and is one of the most severe forms of wear. When a corrosive environment is present, the material loss rate can be significantly increased due to interactions (synergy) between the mechanical and chemical/electrochemical actions. In developing strategies for mitigating such adverse synergistic effect, it is important to understand the complex effect of various parameters on material loss under given tribocorrosion conditions. In this paper, a model is presented for wear-corrosion synergy in abrasive wear by hard particles applicable to many conditions in both the marine renewable (abrasion by high concentrations of large sand particles on tidal turbines) and extractive metallurgy (abrasive wear in mineral extraction). The mechanical wear loss is modeled based on the grooving mechanism (micro-cutting/micro-ploughing). Wear-enhanced corrosion is calculated from the fresh surface areas generated by grooving and the corresponding transient corrosion current. The concept of “corrosion-degraded layer” on the worn surface is introduced to account for the corrosion-enhanced wear; within this corrosion-degraded layer, the material loss rate is higher under the same mechanical wear conditions than in the material that is unaffected by corrosion. Based on the model, the effect of wear conditions on synergy in hard particle wear-corrosion has been discussed. The relative thickness of the corrosion-degraded layer to the depth of hard particle penetration (grooving) in the mechanical wear is found to be an important parameter in determining the relative severity of synergy in different tribo-corrosion systems. Good qualitative agreement has been observed between the predictions and published experimental results obtained from a range of abrasion-corrosion and erosion-corrosion lab testing.
FOXE1 gene expression is linked to the size of papillary thyroid cancer tumors
Authors: Hajian Roya , Javadirad Seyed-Morteza , kolahdouzan Mohsen
Published: September 2023

Introduction: Papillary thyroid carcinoma (PTC), the most prevalent neoplasm of the thyroid, is more common in women than in men.
Objectives: To uncover the expression profile of FOXE1gene in PTC tumor etiology.
Subjects and methods: Microarray and RNA sequencing data on PTC in humans were analyzed. Eleven PTC tumor tissue samples and corresponding healthy tissue samples were collected. RT-qPCR was performed. Data normality, ROC construction, and logistic regression analysis were conducted. PTC tumors, healthy tissues surrounding tumors, patients of different sexes and ages, metastasizing tumors, and tumor variants were assessed for FOXE1 expression.
Results: FOXE1 gene expression was significantly increased in PTC tumors with dimensions less than 10 mm (relative expression= 14.437, p=0.050). A substantial increase in FOXE1gene expression was observed in the healthy tissue adjacent to the tumor, which was less than 10 mm in size, compared to the healthy tissue adjacent to the tumor, which was larger than 10 mm (relative expression= 41.760, p=0.0001). Females diagnosed with PTC showed a significant reduction in FOXE1mRNA levels compared to their male counterparts (relative expression=0.081, p=0.042). In contrast to healthy tissue, there was a significant reduction in FOXE1gene expression in FV-PTC (relative expression = 0.044 and p = 0.0001).
Conclusion: PTC tumors under 10mm have higher FOXE1gene expression than larger tumors; healthy tissue adjacent to smaller tumors also has higher FOXE1 expression. FOXE1 mRNA expression is lower in PTC females compared to males, as well as in FV-PTC compared to healthy tissue.
A multi-sensor framework in google earth engine for spatio-temporal trend analysis of water quality parameters in Anzali lagoon
Authors: Navabian Maryam , Vazifedoust Majid , Varaki Mehdi Esmaeili
Published: September 2023

The Anzali wetland is one of the internationally known freshwater wetlands which provides habitats for many plants and migratory birds, and plays the role of a treatment plant for running water into the Caspian Sea. However, its lagoon is getting shallower due to the inflow of sediment and deposition of organic detritus, and its water quality is deteriorating due to the inflow of wastewater and solid waste from neighboring cities. Therefore, monitoring of water quality parameters (WQP) in Anzali Lagoon is deemed a priority for protection and prevention of its degradation. The current study investigates the environmental condition of the wetland between 2014 to 2021 using remote sensing technology. A multi-sensor framework was developed in google earth engine for spatio-temporal trend analysis of water quality parameters in Anzali lagoon. Water quality parameters incluing TSS, TDS, pH and nitrate were derived using Landsat satellite data based on the calibrated regression equations introduced for this wetland. Spatio-temporal variations of WQP was depicted to determine the critical points and evaluate the trend analysis. The results showed that the WQP fluctuate significantly over time. The spatial distributions indicated that the critical points of the lagoon are changing from the Western to the center and Eastern parts. The comparison of the WQP parameters with the environmental standards confirmed that the lagoon condition is in critical stage, especially in terms of TSS. Nitrate values showed that 50% of the lagoon area exceeds the environmental standards, which indicates the nutritional status. The investigated WQP has had a significant positive trend in most areas, so the lagoon is under high environmental risk and unfriendly human activities should be controlled.
Association of single nucleotide polymorphisms in the F2RL1 gene with clinical and inflammatory characteristics of patients with asthma
Authors: Shrestha Nami , Haji Qahir , Mack Emily , Sinnatamby Tristan , Sandford Andrew J , Cameron Lisa , Vliagoftis Harrisios
Published: September 2023

Background
Proteinase-activated receptor 2 (PAR2) is a G-protein coupled receptor associated with many inflammatory diseases, including asthma. We have shown an association between PAR2 expression in peripheral blood monocytes and asthma severity as well as blood PAR2 mRNA level and lung function. Since F2RL1 (the gene encoding PAR2) polymorphisms affect PAR2 expression, we hypothesize they may affect asthma severity.
Methods
We recruited 76 subjects with asthma of varying severity and collected clinical (FEV1 [% predicted], FEV1/FVC, IgE) and immunological (PAR-2 mRNA, blood eosinophils) disease parameters. We also genotyped these individuals for 3 F2RL1 SNPs (-45C/T, -149C/G, c.621C/T).
Results
We found that the F2RL1 SNP “C” allele of -45C/T (rs1529505) was associated with PAR-2 mRNA and blood eosinophils. F2RL1 SNP c.621C/T (rs631465) was associated with PAR-2 mRNA. The F2RL1 SNP -149C/G (rs2242991) had no association with any of the parameters studied. This study identified one F2RL1 SNP rs1529505 is associated with parameters of asthma, but not asthma severity.
Conclusion
Larger studies are needed to further elucidate the role of PAR2 in the pathophysiology of asthma and the influence of genetic variation.
Eco-anxiety: Ontario Teachers’ Perspectives into Effective Pedagogy in Environmental Education
Authors: Liu Yin
Published: September 2023

Eco-anxiety describes emotional responses such as fatigue, frustration, and anger toward environmental issues. In recent years, there is a growing concern among educators on how this emotion affects learning experience in environmental education. This qualitative study thus examines the manifestation and impact of this anxiety on learning interest, engagement, and motivation. Specifically, through interviewing two experienced Ontario teachers, it delves into its impact and implies professional development to promote environmental education in Ontario classrooms. Primarily, my research finds that anxiety is prevalent in practice; however, it also indicates that teaching anxiety contributes to this learning anxiety. Mainly, a lack of knowledge and experience in this education points to a systemic support that will combat anxiety and empower learners to address the challenge of Climate Change.
Association of grandchild caring with depressive symptoms among migrant older adults in metropolitan areas of China
Authors: Li Zhuo , Yao Dan , Wang Yantao , Zhu Ping , Hong Chenlu , Yang Yingkai , Yin Shushan , Luo Yanan
Published: September 2023

The association of grandchild caring with depressive symptoms among elderly migrants in metropolitan areas remains unclear. This study aimed to investigate the relationship and mechanism between grandchild caring and the risk of depressive symptoms among elderly migrants in metropolitan areas. A questionnaire survey targeting 1000 elderly migrants was conducted in Beijing, China. The study utilized instrumental variables estimation (2SLS-IV) and mediating analysis (KHB method) as the main statistical analysis method. It was revealed that grandchild caring significantly decreases the risk of depressive symptoms among elderly migrants (β=-5.318, p = 0.001). However, high intensity of caring may increase the risk of depressive symptoms (β = 0.665, p = 0.002). It is especially suitable for the elderly migrants who were females, 70 years old and above and resident in Beijing less than 4 years. Social activity participation, emotional feedback from adult children, and emotional interaction with grandchildren adjust the relationship between grandchild caring and mental health of elderly migrants in metropolitan areas. Notably, emotional interaction with grandchildren makes the most significant contribution to the mediating effect. These findings highlight the importance of grandchild caring for the mental health among elderly migrants in metropolitan areas, which can significantly reduce the risk of depressive symptoms of this special group.
The Practice of Key Messages for Optimal Breast Feedings and Associated Factors among Lactating Mothers in Boset District, Oromia, Ethiopia
Authors: Deybasso Haji Aman , Begi Sultan Kalu , Lenjiso Birhanu Deme , Bekele Nardos Tilahun , Getahun Mihiret Shawel , Nehussie Yohannes Mekuria
Published: September 2023

Background: Inadequate breastfeeding results in considerable morbidity, mortality, and long-term unfavorable health outcomes. Key messages for optimal breastfeeding are an integral part of Essential Nutritional Action designed to enhance children's nutritional status, especially those under the age of two. However, the level of practice of key messages for optimal breastfeeding and associated factors among lactating mothers remain unknown.
Objective: To assess the level of practices of key messages for optimal breastfeeding and associated factors among lactating mothers living in Boset District, Oromia, Ethiopia, 2022.
Methods: A community-based cross-sectional study was conducted among 418 lactating mothers from January 1st to February 28th, 2022. A systematic random sampling technique was used to select the study participants. Data were collected by interviewer-administered questionnaires. The collected data were entered into Epi info version 7 and exported to SPSS version 25 for analysis. Binary logistic regressions were performed to examine the association between the independent and dependent variables. Adjusted Odds Ratios with a 95% confidence interval were used to estimate the strength of the associations. P-value< 0.05 was used to declare statistical significance.
Result: The overall prevalence of key messages for optimal breastfeeding was 63.9% (95% CI: 59.1-68.2). The odds of practicing key messages for optimal breastfeeding were higher for mothers who attended antenatal care four and above times (AOR =2.7, 95% CI: 1.4–5.3), received counseling on breastfeeding during postnatal care (AOR = 3.7, 95% CI: 2.2–6.4), had good knowledge of breastfeeding (AOR = 6.2, 95% CI: 3.6–10.7), and had favorable attitude towards breastfeeding (AOR = 6.1, 95% CI: 3.5–10.6).
Conclusion: The practices of breastfeeding key messages were below the recommended universal coverage (90%). The number of antenatal care visits, counseling on breastfeeding, level of knowledge, and attitude towards breastfeeding were factors associated with good practices and key messages for optimal breastfeeding among lactating mothers. Behavioral change communications on key messages for optimal breastfeeding are recommended to improve optimal breastfeeding practices in the study area.
Empirical Bayesian Inference for Shape-Scale Family Based
on the Generalized Progressive Hybrid Censoring Scheme
Authors: Maswadah M.
Published: September 2023

In this study, the empirical Bayes method has been applied to a general lifetime model based on the generalized progressive hybrid censored scheme and compared to the fully Bayes method and the maximum likelihood method. The comparisons are made in terms of the root mean squared errors via Monte Carlo simulations. The simulation results are quite favorable to the fully Bayesian model based on the informative prior. However, the empirical Bayes provides better estimates and outperforms the maximum likelihood estimates and the fully Bayes based on the same prior or when there is a wrong choice of the prior hyperparameters. Finally, a numerical example is given to demonstrate the efficiency of the proposed methods.
REPUTATIONAL RISK MANAGEMENT STRATEGY AT INDONESIAN SHARIA BANK AND MUAMALAT INDONESIAN BANK
Authors: Utami Neni , Subagiyo Rokhmat , Asiyah Binti Nur
Published: September 2023

Abstract. BSI and BMI suffered significant losses due to reputational risk. Reputation risks that occur can be properly handled so that losses that arise can be recovered immediately. This study aimed to determine the application of risk management to BSI and BMI and the application of reputation risk to BSI and BMI. The results of this study indicate that BSI and BMI have implemented risk management in accordance with POJK No. 65 of 2016. BSI and BMI have specific organizations to deal with risks, procedures, and the same problem focus on dealing with reputation risk even though the steps for implementing procedures between the two are different. BSI is more focused on strategic steps taken in overcoming risks, while BMI is not only focused on strategic steps taken but also focused on media coverage and communication management.
CHALLENGES IN APPLICATION BASED ACCOUNTING AND FINANCIAL MANAGEMENT PRACTICES FOR MICRO SMALL AND MEDIUM ENTERPRISES
Authors: BINTI SUWADJI LANTIP SUSILOWATI
Published: September 2023

Abstract: Many micro, small and medium enterprises (UMKM) have not recorded their business finances so they cannot monitor their business development. For this reason, the purpose of this study is to carry out mentoring activities for micro, small and medium enterprises entrepeneurs in the practice of recording their business finances by using digital applications so that it is simpler and easier to present their financial reports according to SAK EMKM standards. Research that uses a qualitative approach with this type of descriptive research chooses the digital applications chosen to be used are SI APIK and Teman Bisnis because these two applications are easy to access with Android and are quite simple in their practical stages to be practiced with the UMKM community of the Cemoro Barong association, located in Tapan Village, Kedungwaru District, Tulungagung Regency, East Java Province which consists of 18 UMKM with various types of service, trading and manufacturing businesses. As a result, entrepreneurs in the community are enthusiastic about implementing this accounting application. The entrepreneurs can use this application to assist them in controlling merchandise stocks to compiling financial reports according to SAK EMKM standards. This application is suitable for use in recording business finances both services, trade and manufacturing.
HEALTH SERVICE EFFICIENCY: COST ANALYSIS OF TIME DRIVEN ACTIVITY BASED COSTING METHODS IN CAESAR SURGERY SERVICES IN PKU MUHAMMADIYAH HOSPITAL, YOGYAKARTA
Authors: Desitama Faizal Satria , Habib Muhammad Alhada Fuadilah
Published: September 2023

Negative difference between the fee for cesarean surgery services provided by the hospital and the tariff claimed by BPJS resulted in the hospital bearing the cost difference. This study aims to determine the level of inefficiency in cesarean surgery healthcare services through cost calculation using the Time Driven Activity Based Costing (TDABC) method at PKU Muhammadiyah Yogyakarta Hospital. This study uses a qualitative approach with a case study strategy. The subjects of this research were determined using purposive sampling approach, involving 5 informants as personnel in each cost pool. In-depth interviews and documentation of internal financial data were used as data collection techniques. The results of this study show the presence of inefficiency in the Accommodation cost pool and the Cleaning service cost pool. Inefficiency in cesarean surgery services can be determined after analyzing the utilization of capacity, which is the end result of cost calculation using the TDABC method. The stages of cost analysis using the TDABC method in this study include: 1) Identification of Cost Pools, 2) Identification of total costs for each cost pool, 3) Determination of practical capacity and capacity cost rate for each cost pool, 4) Determination of time estimates for each cost pool, 5) Cost calculation, and 6) Analysis of capacity utilization to determine the level of inefficiency by calculating the percentage of available capacity compared to idle capacity. The results of this study are expected to provide input regarding the optimization of idle capacity, cost efficiency, and improvement of healthcare service processes in the hospital.
Shattering Minds: Experiences of Mental Illness in Modernist Finnish Literature
Authors: Ovaska Anna
Published: September 2023

This study offers a new perspective on unusual and unsettling experiences that are often interpreted as “mental illnesses” and on the techniques through which literary representations invite readerly responses and engagement. The book examines how four Finnish modernist writers, Helvi Hämäläinen, Jorma Korpela, Timo K. Mukka, and Maria Vaara, construct experiences of shattering and distress as bodily experiences that are embedded in the social and material world and entangled with social and cultural norms that govern subjectivity, gender, and sexuality. Drawing on narrative theory, theories of embodied cognition, phenomenology of illness, and feminist theory, the analyses show how literary works can invite readers to respond emotionally and to reflect on our views of the human mind and its interaction with the world. The book sheds light on the fictional portrayals and techniques of representation and on the ethics of narrating and reading about painful experiences. It also illuminates the ways the mind, body, consciousness, and mental distress are discussed in Finnish modernist literature and situates the texts in the international modernist tradition.
Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models
Authors: Brighi Pietro , Ljubotina Marko , Serbyn Maksym
Published: September 2023

Quantum kinetically constrained models have recently attracted significant attention due to their anomalous dynamics and thermalization. In this work, we introduce a hitherto unexplored family of kinetically constrained models featuring conserved particle number and strong inversion-symmetry breaking due to facilitated hopping. We demonstrate that these models provide a generic example of so-called quantum Hilbert space fragmentation, that is manifested in disconnected sectors in the Hilbert space that are not apparent in the computational basis. Quantum Hilbert space fragmentation leads to an exponential in system size number of eigenstates with exactly zero entanglement entropy across several bipartite cuts. These eigenstates can be probed dynamically using quenches from simple initial product states. In addition, we study the particle spreading under unitary dynamics launched from the domain wall state, and find faster than diffusive dynamics at high particle densities, that crosses over into logarithmically slow relaxation at smaller densities. Using a classically simulable cellular automaton, we reproduce the logarithmic dynamics observed in the quantum case. Our work suggests that particle conserving constrained models with inversion symmetry breaking realize so far unexplored dynamical behavior and invite their further theoretical and experimental studies.
erum interleukin content and lipid metabolism in cows with subclinical ketosis
Authors: KIBKAŁO DMYTRO , TYMOSZENKO OLGA , WIKULINA HALINA
Published: September 2023

This paper analyses the diagnostic utility of interleukins (1, 4, 6) and lipid metabolism products (cholesterol, triacylglycerols, lipoprotein fractions) in subclinical ketosis in cows. It was found that serum levels of proinflammatory (IL-1 and IL-6) and anti-inflammatory (IL-4) interleukins in cows with ketosis did not differ from those in clinically healthy animals. This therefore indicates the absence of inflammation in the subclinical form of ketosis. These data were also confirmed by normal α1- and α2-globulin levels. IL-6 is known to increase the synthesis of acute phase inflammatory proteins. There was no significant difference in the IL-4 content between the experimental and control groups of cows. In the subclinical form of ketosis in cows, abnormalities in lipid and lipoprotein metabolism were detected in the form of hypertriglyceridaemia and hyperlipoproteinaemia with very low-density lipoproteins, an increase in low-density lipoproteins, and a decrease in very high-density lipoproteins. This was verified by similar changes in β-lipoprotein levels and lipoprotein fractions and was specific to the first stage of lipomobilisation syndrome.
Mutations and polymorphisms in mitochondrial genome of dogs with solid mammary carcinoma – a preliminary study
Authors: ZIÓŁKOWSKA KAJA , KOWAL KRZYSZTOF , TKACZYK-WLIZŁO ANGELIKA , ŚMIECH ANNA , ŚLASKA BRYGIDA
Published: September 2023

In recent years, the association between mitochondrial DNA (mtDNA) changes and tumorigenesis has been discussed. In contrast to human medicine, there are still few studies on the molecular basis of canine tumors. One of the most commonly diagnosed, solid mammary carcinoma, is characterized by its aggressiveness, difficult treatment, and generally poor prognosis. The aim of the study was to reveal mutations and polymorphisms in mtDNA in dogs with solid mammary carcinoma and to determine the relationship of these changes with the process of neoplastic transformation. Blood, healthy tissue, and neoplastic tissue samples were collected from two crossbreed dogs diagnosed with G3 and G2 solid mammary carcinoma. Subsequently, for the first time, Next Generation Sequencing (NGS) was used to analyze the whole genome mtDNA of dogs with solid mammary carcinoma. Thus, bioinformatic analyses included all 37 mitochondrial genes. As a result, 10 polymorphisms and 20 mutations were identified. Most polymorphisms/mutations were found in the dog with the more advanced stage of the disease (G3). Twelve of the thirty changes identified have not been described in the literature so far. These include eleven mutations in COX2 (m.7308A>G), ATP6 (m.8536C>T), ND4L (ins.9913_9914AG, ins.9913_9914TG, m.10165C>T), ND4 (m.10204C>T), CYTB (m.16248A>G, m.16268A>G), D-loop (m.16378G>A, m.16408G>A, m.16507T>A) which may be related to canine tumorigenesis.
Optimizing PID Gains of a Vehicle using the state-of-the-art Metaheuristic Methods
Authors: AFŞAR Mustafa Atakan , ARSLAN Hilal
Published: September 2023

PID controllers are important control methods that are widely used in industrial processes. Proper tuning of PID gains is critical for achieving the state-of-the-art system performance. Therefore, optimizing PID gains is an important research topic in the field of control engineering. In this study, PID controller gains are automatically tuned using metaheuristic optimization methods. These methods use an iterative approach to calculate optimal values of PID controller gains based on different optimization techniques. The interaction between artificial intelligence and control systems requires a multidimensional approach across different disciplines. In the study, we perform Particle Swarm Optimization, Gray Wolf Optimization, Whale Optimization Algorithm, Firefly Algorithm, Harris Hawks Optimization, Artificial Hummingbird Algorithm and African Vulture Optimization Algorithm to determine PID gains. In the simulation, step input is applied to the dynamic equation of the unmanned free-swimming submersible vehicle. The fitness function is determined with respect to controller integral square error, settling time value, and maximum percent overshoot value. We also evaluate the optimization time of the selected algorithms based on the fitness function. Experimental results present that Artificial Hummingbird Algorithm, Gray Wolf Optimization and Particle Swarm Optimization achieve significant performance. This underlines that using metaheuristic methods in PID gain optimization increase overall system performance.
Novel Flavanone Naringenin Derivative with Anti-Inflammatory Activity
Authors: de Souza Rodrigo , Hilgenberg Lívia , Pinto Ana , Costa Renyer , Simplicio Fernanda , Lima Emerson
Published: September 2023

Naringenin is a flavonoid with several biological activities already reported but with few biological applications in the pharmaceutical field. In this work, a new flavanone, called carboxymidamide (DCHA), synthesized through the condensation reaction between naringenin and aminoguanidine is structurally confirmed through spectroscopic analysis of nuclear magnetic resonance, mass spectrometry and Fourier transform infrared. DCHA was not toxic to human fibroblasts and inhibited macrophage activation in vitro. In vivo, it suppressed leukocyte migration in lipopolysaccharide (LPS)-induced peritonitis and reduced zymosan-induced paw edema. Molecular docking simulations of DCHA in the active site of the enzymes inducible nitric oxide synthase, cyclooxygenase-2 and phosphodiesterase type 4 indicate that the anti-inflammatory activity of this new flavanone can be explained by the inhibition of these target enzymes. This is the first work to present the synthesis of a flavonoid derivative with aminoguanidine that showed a high anti-inflammatory potential.
Analyzing Sustainable Practices in Fashion Supply Chain
Authors: Soni Sheetal , Baldawa Sejal
Published: September 2023

Fast fashion brands create high quantities of synthetic, petroleum-based garments that result in high levels of textile waste and emissions. To change the dreadful tag of hazardous production, top-notch fast fashion leaders started paying attention towards adopting sustainable practices, including sustainable supply chain management (SSCM).This paper conducts a structured review of the annual reports on the topic of energy efficiency and environmental sustainability practices adopted by fashion brands in the supply chain management context. This study tries to identify the factors and classification influencing energy efficiency and environmental sustainability initiatives that impact supply chain performance, the customer perspective and the different technologies supporting energy efficiency and sustainable practices based on the analysis of the data related to the sustainability of top fashion brands from their past five year annual reports.
Modeling of water surface profile in non-prismatic compound channels
Authors: Kaushik Vijay , Kumar Munendra , Naik Bandita , Parsaie Abbas
Published: September 2023

Estimating the water surface elevation of river systems is one of the most complicated tasks in formulating hydraulic models for flood control and floodplain management. Consequently, utilizing simulation models to calibrate and validate the experimental data is crucial. HEC-RAS is used to calibrate and verify the water surface profiles for various converging compound channels in this investigation. Based on experimental data for converging channels (θ = 5°, 9°, and 12.38°), two distinct flow regimes were evaluated for validation. The predicted water surface profiles for two relative depths (β = 0.25 and 0.30) follow the same variational pattern as the experimental findings and are slightly lower than the observed values. The MAPE for the simulated and experimental results is less than 3%, indicating the predicted HEC-RAS value performance and accuracy. Therefore, our findings imply that in the case of non-prismatic rivers, the proposed HEC-RAS models are reliable for predicting water surface profiles with a high generalization capacity and do not exhibit overtraining. However, the results demonstrated that numerous variables impacting the water surface profile should be carefully considered since this would increase the disparities between HEC-RAS and experimental data.
Missão, visão e valores organizacionais dos Institutos Federais De Educação, Ciência e Tecnologia do Brasil
Authors: Rosa Karina Graziele Corrêa , Downes Lilian Cristina Garcia , Lugoboni Leonardo Fabris
Published: September 2023

O presente estudo buscou identificar as estruturas da missão, visão e valores organizacionais dos 38 Institutos Federais de Educação, Ciência e Tecnologia (IFs) do Brasil. As declarações institucionais foram analisadas conforme os modelos definidos por Pearce (1982), Westley e Mintzberg (1989) e Guiso et al. (2015). Os resultados da pesquisa apontam que 37% dos Institutos analisados possuem apenas 3 dos 8 elementos do modelo proposto por Pearce (1982) em suas missões, sendo que o elemento mais presente faz referência a produtos ou serviços. Com relação à análise da visão, 72% dos IFs mencionaram somente 2 dos 5 componentes do método proposto por Westley e Mintzberg (1989), e o componente mais utilizado se refere aos “ideais das organizações”, que corresponde a 97,3%. No que se refere aos valores organizacionais, conclui-se que os valores constantes da “categoria 1” definida por Guiso et al. (2015) foram evidenciados em todos os 38 Institutos analisados, e quanto à frequência desses termos de cada uma das nove categorias estabelecidas pelos autores supracitados foi observado o total de 348 palavras, destas, 120 pertencem aos valores constantes na “categoria 1”. A pesquisa contribui para o tema na literatura especialmente no que tange a pesquisas que analisaram a estrutura das declarações institucionais, sobretudo em organizações brasileiras, bem como, para auxiliar os gestores dos Institutos a aprimorarem o planejamento estratégico destes, contribuindo para a tomada de decisão e para uma melhor competitividade dos IFs.
Pharmacists’ Medication Reconciliation Interventions During Admission
and Transfer from an Emergency Department at a Tertiary Care
Hospital: A Randomized Pilot Study and Evaluation of Physician and Patient Perceptions
Authors: Joseph Ashitha George , Saji Santra , Kumbhar Anagha Nivrutti , G. Shivakumar , Bhandari Ramesh , Ganachari M. S.
Published: September 2023

Aim:

The study aimed to assess the impact of pharmacist interventions during the transition
of care.

Background:

Medication discrepancies can occur at various levels of transition, such as during
admission, the transition from emergency to special wards or from special to general wards, and
during discharge. Discrepancies can be detected through the process of medication reconciliation.

Objective:

The objective of the study was to compare discrepancies among patients exposed to
pharmacist intervention groups and those who were not and assess the perception of healthcare
professionals and patients towards integrating pharmacists in the transition care process.

Methods:

A pharmacist-led interventional study was conducted for six months on patients above
18 years of age and either sex who were admitted to the emergency department, had chronic diseases,
and subsequently transferred to another department (any). The patients were randomized into
intervention and control groups. The pharmacist performed a medication reconciliation and
medication review to identify discrepancies in every transition in both the groups, and then reported
to the treating physician to resolve in the intervention group.

Results:

Among the 73 patients recruited in the study, 152 discrepancies were identified. The total
discrepancies observed in the control and intervention groups were 78 (51.3%) and 74 (48.6%), respectively.
The majority, 35.53%, were found during the transition from emergency to special
wards. The physician, upon pharmacist recommendations, accepted and resolved 48 discrepancies
in the intervention group. The healthcare professional acceptance rate of pharmacist interventions
was 64.86%.

Conclusion:

The transitions of care are at risk for errors due to medication discrepancies, and
pharmacists could potentially identify and resolve discrepancies. Healthcare professionals and patients
reported to be satisfied by the involvement of clinical pharmacists in the healthcare team.
A Critical Appraisal of Functionalized 2-Dimensional Carbon-Based
Nanomaterials for Drug Delivery Applications
Authors: Singh Dilpreet , Gupta G.D. , Gupta Nimish , Verma Princi , Dey Abhisek , Kaur Simranjeet , Kumar Akshay , Raj Namandeep
Published: September 2023

The development of an efficient and innovative drug delivery system is essential to improve
the pharmacological parameters of the medicinal compound or drug. The technique or manner used to
improve the pharmacological parameters plays a crucial role in the delivery system. In the current scenario,
various drug delivery systems are available where nanotechnology has firmly established itself in
the field of drug delivery. One of the most prevalent elements is carbon with its allotropic modifications
such as graphene-based nanomaterials, carbon nanotubes, carbon dots, and carbon fullerenes, these
nanomaterials offer notable physiochemical and biochemical properties for the delivery applications due
to their smaller size, surface area, and ability to interact with the cells or tissues. The exceptional physicochemical
properties of carbon-based 2D nanomaterials, such as graphene and carbon nanotubes, make
them attractive candidates for drug delivery systems. These nanomaterials offer a large surface area,
high drug loading capacity, and tunable surface chemistry, enabling efficient encapsulation, controlled
release, and targeted delivery of therapeutic agents. These properties of the nanomaterials can be exploited
for drug delivery applications, like assisting the target delivery of drugs and aiding combination
molecular imaging. This review emphasizes on the recent patents on 2D carbon-based nanomaterial and
their role in drug delivery systems. Carbon-based 2D nanomaterials present a wealth of opportunities
for advanced drug delivery systems. Their exceptional properties and versatility offers great potential in
improving therapeutic efficacy, minimizing side effects, and enabling personalized medicine and the
recent patents on 2D nanomaterial.
MXenes-based Multifunctional Nanomaterials for Lithium-ion Batteries:
Opportunities and Challenges
Authors: Bhandari Tika Ram , Thapa Yub Narayan , Dhakal Chiranjibi , Adhikari Rameshwar
Published: September 2023

MXene-based multicomponent materials are 2D substances derived from transition metal (M) with carbide/nitride combinations having several propitious uses, including application in energy storage devices for high-performance electrodes for Lithium-ion batteries (LIBs) fabrication. The suitability of these new classes of materials for LIB electrodes can be attributed to their high conductivity combined with their excellent surface properties desirable for electrode applications, such as fast charge-discharge capability, high storage capacity and high rate capacity. However, there are several challenges possessed by MXene-based nanomaterials in the application of their electrodes in future flexible and wearable devices, demanding more research work and development strategies. After a brief overview of MXenes used in batteries, this paper deals with the synthesis, morphology-properties correlations, and their performance. Finally, this paper headlines the advantages, limitations, and challenges of MXene-based electrodes for LIBs, ending with concluding remarks.
Smart Village: A Means of Empowering the Krisik Village Community through an Intelligent Information System Based on Online Administration Service Solutions
Authors:   Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, Teguh Prayoga Muhammad , Budi Astut Ani , Putu Rawi Rotchildi Gusti Ayu , Maria Kalang Olyvia , Ariq Deriz Putra Muhammad , Ibnu Muhammad
Published: September 2023

Administration is a fundamental need of society. The implementation is still not practical and simple,resulting in a domino effect that can have an impact on other sectors such as the economy. The demographic condition of Krisik Village shows that time inefficiency will result in a lot of losses. Moreover, the absorption of existing village funds shows that the use of paper for administration is still very large which is not in accordance with the 13th point of the Sustainable Development Goals, coupled with the COVID-19 pandemic which has exacerbated the situation with the imposition of various restrictions on sectors in society. This is an urgency for a solution that facilitates the community in the administration sector and the Krisik Village needs a solution to facilitate the administrative process in terms of distribution delivery and management by the village apparatus in order to create an effective, efficient, and face-to-faceminimal system. Based on the needs and conditions of Krisik Village, an online administration solution, namely "Smart Village: Empowerment of Krisik Villages in Blitar Regency through an Intelligent Information System for Application-Based Online Community Administration Services", is an application that can accommodate administrative processes at the village level using the Android system.
Perancangan Zona Hisap Madu Hutan Pelawan Dan Produk Madu Sachet Sebagai Upaya Meningkatkan Kualitas Produk Dan Layanan
Authors:   Departemen Teknik Industri, Fakultas Teknik, Universitas Brawijaya, Indonesia, Oktavianty Oke , Junining Esti ,   Departemen  Ilmu  Bahasa  Inggris,  Fakultas  Ilmu  Budaya, Universitas  Brawijaya, Indonesia, Suhartini Sri ,   Departemen Teknologi Industri Pertanian, Fakultas Teknologi  Pertanian, Universitas Brawijaya, Indonesia, Sugiono Sugiono ,   Departemen Teknik Industri, Fakultas Teknik, Universitas Brawijaya, Indonesia, bin Mohamad Effendi ,   Fakulti Kejuruteraan Pembuatan, Universiti Teknikal Malaysia Melaka, Malaysia, Setiawan Yudi ,   Jurusan Teknik Mesin, Fakultas Teknik, Universitas Bangka Belitung, Indonesia
Published: September 2023

Hutan Pelawan yang berlokasi di Desa Namang, Kabupaten Bangka Tengah, Provinsi Kepulauan Bangka Belitung memiliki potensi yang sangat besar sebagai hutan kehayati yang juga dimanfaatkan oleh masyarakat sebagai sarana wisata edukasi dan sebagainya. Salah satu andalan dan daya Tarik hutan ini adalah wisata menghisap madu secara langsung dari sarang lebah. Sayangnya, lokasi dan fasilitas yang ada sebelumnya sangat tidak kondusif. Selain itu, produk madu yang dimiliki hanya memiliki varian madu botol ukuran 300 ml yang pemasarannya masih belum maksimal. Dalam kegiatan pengabdian kepada masyarakat ini, tim pelaksana melakukan perancangan dan pembuatan zona hisap madu untuk meningkatkan daya Tarik pengunjung. Selain itu, tim pelaksana juga membuat rancangan dan prototype madu sachet Pelawan sebagai upaya diversifikasi produk dan memperluas target pasar madu Pelawan
Social Engineering ToFloating Net-Cage Fish FarmersIn Ranu Klakah Lumajang, East Java
Authors:   Faculty of Fisheries and Marine Sciences Universitas Brawijaya, Kilawati Yuni , Maimunah Yunita , Mukhammad Amrillah Attabik , Muttaqin Adharul ,   Department of Electrical Engineering, Brawijaya University, Shofwan Shofwan ,   Faculty of Economics and Business, University of Brawijaya
Published: September 2023

Apart from being a tourist destination,Ranu Klakah, is also used as a fishing business location for capture and aquaculture. Local people use it as a place for fish farming using the floating net cage (KJA) method which has quite a large potential. Currently problems faced by floating net cage fish farmers in Ranu Klakah is the unavailability of adequate fishery facilities and infrastructure, both fisheries and aquaculture, the low application of fishery technology in the field of aquaculture and marketing of fishery products and the low quality of human resources for fisheries sector business. The Doctoral Community Service Program (Doktor Mengabdi/DM) Universitas Brawijaya offers several programs to help solve some of the problems encountered by fish farmers. These solutions, aimed to improve community knowledge about best management practice of aquaculture using floating net-cage system, increasing community knowledge about digital product marketing and improving the quality and quantity of fish production in floating net cage systems in Ranu Klakah to attract consumers with wider coverage area and high time flexibility
Peningkatan Kapabilitas, Dayasaing Dan Teknologi Produksi Kopi Wine Sebagai Produk Unggulan Penyangga Meru Betiri Di Desa Kebonrejo Kec. Kalibaru, Banyuwangi
Authors:   FakultasTeknologi PertanianUniversitas Brawijaya, Bekti Sunarharum Wenny , Asmaul Mustaniroh Siti ,   FakultasTeknologi PertanianUniversitas Brawijaya, Dina Riana Fitria ,   Fakultas Pertanian, Brawijaya University, Farah Azizah Devi ,   Fakultas Ilmu Administrasi, University of Brawijaya
Published: September 2023

Kelompok Kopi “Maharadja Kalibaroe” dan Kelompok Kopi “Makmur Jaya” berlokasi di Desa Kebonrejo, Kecamatan Kalibaru, Kabupaten Banyuwangi yang merupakan salah satu desa penyangga Taman Nasional Meru Betiri (TNMB). Tujuan kegiatan Doktor Mengabdi (DM) adalah meningkatan kemampuan dan efisiensi proses produksi kopi wine dengan implementasi alih teknologi tepat guna serta penguatan manajemen kelembagaan. Metode kegiatan yang dilakukan adalah brainstorming dan FGD, bimtek dan pendampingan, fasilitasi dan diseminasi alih teknologi produksi, serta monitoring dan evaluasi. Hasil pelaksanaan kegiatan diantaranya diskusi solusi dan strategi bersama, memberikan inovasi resep produksi kopi dan desain label kemasan, pengelolaan usaha, penyampaian standar GMP dan penyusunan SOP, serta transfer teknologi produksi. Secara umum, kegiatan berjalan lancar dan telah memberikan dampak positif pada mitra kelompok kopi
Bimbingan Teknis Peningkatan Informasi dari Pemodelan Deterministikdan Stokastik untuk Data Sektoral Diskominfo Kabupaten Malang
Authors:   Departemant Statistika FMIPA Universitas Brawijaya, Malang, Indonesia, Kusdarwati Heni , Pramoedyo Henny , Amaliana Luthfatul
Published: September 2023

Departemant Statistika FMIPA Universitas Brawijaya, Malang, Indonesia
Induksi Metode Continuously Dynamic Mixing (Cdm) Untuk Optimasi Produksi Garam Dengan Teknologi Greenhouse Salt Tunnel (Gst) Di Pesisir Selatan Kabupaten Malang
Authors:   Pusat Studi Pesisir dan Kelautan, Universitas Brawijaya, Malang, Indonesia, Pramudia Zulkisam , Aziz Amin Abd. , Al Zamzami Ilham Misbakudin , Tiya Yanuar Adi , Agung Lestariadi Riski , Mariya Ulfa Siti ,   Fakultas Matematika  dan  Ilmu  Pengetahuan  Alam, Universitas  Brawijaya,  Malang, Indonesia, Kurniawan Andi ,   Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya, Malang, Indonesia
Published: September 2023

Garam merupakan komoditas strategis yang tidak dapat digantikan oleh komoditas lain. Kebutuhan garam terus meningkat dimana Propinsi Jawa Timur merupakan lumbung garam nasional. Kabupaten Malang memiliki potensi wilayah di pantai selatan. Hanya saja, sampai dengan kegiatan ini dimulai, Kabupaten Malang belum menjadi penghasil garam. Kegiatan ini dilakukan dengan menginduksikan metode Continuously Dynamic Mixing (CDM) yang diterapkan dalam Greenhouse Salt Tunnel (GST) untuk mengkreasi produksi garam di Pantai Selatan Kabupaten Malang. Mitra kegiatan ini adalah Kelompok Usaha Garam Rakyat (Kugar) Bajulmati Sejahtera yang merupakan kelompok usaha garam pertama di Kabupaten Malang. Mitra memiliki masalah terkait dengan teknis produksi garam untuk menghasilkan garam yang berkualitas baik (NaCl > 95%). Indikator keberhasilan kegiatan pengabdian kepada masyarakat ini adalah: 1) teknologi GST di lokasi mitra sudah menggunakan metode CDM untuk produksi garam; 2) peningkatan pengetahuan dan keterampilan mitra dalam pengaturan air dalam metode CDM dalam GST; dan 3) Mitra dapat memproduksi garam berkualitas K-1 dengan peningkatan kapasitas produksi lebih dari 50%. Kegiatan pengabdian kepada masyarakat ini telah dapat mengkreasi produksi garam untuk pertama kali di Pantai Selatan Kabupaten Malang.