bluuebunny/crossref_metadata_2025 huggingface dataset:
Las relaciones interdimensionales desde la educación física en la infancia preescolar
Authors: Vázquez Peña Saily
Published: August 2023

El presente artículo es resultado de una investigación que se desarrolla en opción al grado científico del Doctorado en Ciencias Pedagógicas. Aborda un estudio histórico sobre el comportamiento y la evolución de las relaciones interdimensionales desde la educación física en Cuba para el perfeccionamiento de la motricidad fina en los niños de la infancia preescolar. Para el estudio se asumen cuatro etapas que se definen a partir del inicio de esta dimensión en la primera infancia. Para cumplir con este objetivo, se seleccionaron aquellos acontecimientos, sucesos o hechos relevantes que determinaron el comportamiento de este proceso y le imprimieron nuevas características que  constituyeron un viraje o ruptura con respecto a la línea de desarrollo que manifestaba dicho suceso y que marca una nueva etapa a partir de hitos.
La lúdica como dimensión antropológica: un estado de la cuestión
Authors: Pino Rúa Yolanda Astrid , Runge Peña Andres Klaus
Published: August 2023

En este artículo se presentan los resultados del estado de la cuestión realizado para situar la investigación doctoral “La lúdica como dimensión antropológica en los trayectos biográficos de maestros y maestras”. La búsqueda se realiza partiendo de las categorías lúdica, maestros y maestras, así como la dimensión antropológica; de esta manera, el rastreo se hace en los buscadores especializados, en repositorios de universidades nacionales e internacionales, en la producción de los grupos de investigación avalados por Colciencias y que tienen en su centro el estudio de lo lúdico, y en revistas especializadas. El rastreo realizado evidencia una amplia producción académica alrededor de lo lúdico en la escuela, que se ha centrado en el juego, los dispositivos de aprendizaje, la recreación y el movimiento, pero que desconoce la lúdica como dimensión antropológica. Se concluye que la investigación alrededor de lo lúdico debe empezar a abordar nuevos temas que le permitan tener más relevancia en la vida de los sujetos y en la esfera académica.
Las políticas locales de recreación y deporte social en Córdoba, Argentina
Authors: Griffa Marcos
Published: August 2023

El presente artículo se propone realizar un primer rastreo exploratorio de las políticas locales de recreación y deporte social en la ciudad de Córdoba (Argentina) en el periodo 1980-2020. Este trabajo forma parte del proyecto de investigación “Políticas públicas de recreación en la provincia de Córdoba” que llevamos adelante desde la Facultad de Educación Física de la Universidad Provincial de Córdoba (Argentina). A través de la indagación y análisis de informes de gestión, normativas, sitios web, documentación institucional, y unas primeras entrevistas exploratorias a miembros de equipos técnicos y responsables de programas, podemos observar que a pesar de los cambios de gestión en el gobierno municipal y provincial es posible identificar una continuidad tanto de las políticas de recreación y deporte social, como también del vínculo sostenido con instituciones sociales, principalmente centros vecinales, en la implementación de estas. Otros aspectos que merecen nuestra atención y análisis refieren a la descentralización de estas políticas, a la construcción de infraestructura para la realización de actividades deportivas y recreativas, y a la participación de diversos actores en su gestión y desarrollo. En este artículo haremos referencia también a la estructura institucional desde la cual se llevaron a cabo estas políticas en Córdoba, los organismos que las constituyen, y los modelos de gestión que han sido diseñados e implementados para tal fin.
O direito à moradia na Cidade Sustentável
Authors: Pasquotto Geise Brizotti , Salcedo Rosio Fernandez Baca
Published: August 2023

A habitação é um direito para assegurar a dignidade da pessoa humana. Embora seja um direito independente, sua ausência compromete o exercício pleno de outros direitos básicos, tais como saúde, educação, trabalho e lazer. A moradia adequada, a qualidade de vida urbana e a sustentabilidade social estão intrinsecamente vinculadas à habilidade do governo federal, estadual e municipal de criar leis, executar e supervisionar o cumprimento das regulamentações urbanas para um planejamento efetivo e eficiente. Objetivo: percorrer a evolução legal do conceito de direito à moradia no âmbito internacional e nacional. Metodologia: O trabalho está dividido em três eixos: o primeiro demonstra como o conceito de direito à moradia foi construído e o segundo, aborda esta temática na constituição do Brasil. O terceiro visa incorporar à análise da legislação brasileira as políticas públicas habitacionais realizadas.  Resultados: Os resultados visam verificar se houve grande impacto da legislação internacional e nacional nas políticas públicas habitacionais, com enfoque especial nas ações federais, implementadas no Brasil.
PEDİATRİ HEMŞİRELİĞİ DERSİ ALAN ÖĞRENCİLERİN KÜLTÜRE ÖZGÜ BAKIM VERME YETERLİLİĞİ, YAŞADIĞI GÜÇLÜKLER VE ÇÖZÜM ÖNERİLERİ
Authors: TUTAR Şerife , KAROL Tuğçe
Published: August 2023

Amaç

Bu araştırmada; pediatri hemşireliği dersi alan öğrencilerin

kültüre özgü bakım verme yeterliliği, yaşadığı

güçlükler ve çözüm önerilerinin belirlenmesi amaçlanmıştır.

Gereç ve Yöntem

Araştırmaya 169 öğrenci dahil edilmiştir. Araştırmanın

verileri “Tanıtıcı Bilgi Formu” ve “Hemşire Kültürel

Yeterlik Ölçeği” kullanılarak online olarak toplanmıştır.

Verilerin analizinde SPSS 20.0 programı kullanılmış

olup demografik özelliklere göre karşılaştırmalar

t-testi ve ANOVA ile gerçekleştirilmiştir. Araştırmanın

yürütülebilmesi için etik kurul onayı ve katılımcılardan

bilgilendirilmiş onam alınmıştır.

Bulgular

Araştırmaya katılan öğrencilerin yaş ortalamaları

22,72±1,77 yıl ve çoğunluğu (%74) kadındır. Öğrencilerin

Hemşire Kültürel Yeterlik Ölçeği’ne verdikleri puan

ortalaması 72,20±11,41 olarak hesaplandı. Farklı bir

kültürden gelen hastaya bakım verme deneyimi olmayan

öğrencilerin kültürel yeterlik düzeyleri (75,03±10,91)

deneyimi olan öğrencilere göre (70,73±11,44) anlamlı

düzeyde yüksek bulunmuştur (p=0,019). Hemşirelik eğitimi

boyunca alınan derslerin farklı kültürdeki hastalara

bakım vermede yeterli olduğunu düşünen öğrencilerin

kültürel yeterlik düzeyi (74,76±9,34) yeterli olduğunu düşünmeyenlere

göre (69,15±12,88) anlamlı düzeyde yüksek

bulunmuştur (p=0,002).

Sonuç

Hemşirelik eğitimi boyunca öğrencilerin yabancı dil

eğitimi konusunda desteklenmesi, farklı kültürlere

özgü uygulamaların ders içeriklerinde yer alması ve

mümkün olduğunca öğrencilere değişim programları

ile farklı ülkelerdeki hastalarla çalışma imkanı sağlanmasının

kültürel yeterlik düzeyini artıracağı düşünülmektedir.
Yaşam Doyumu Ölçeği’nin 5-6 Yaş Grubu Çocuklar İçin Türk Kültürüne Uyarlanması: Geçerlik ve Güvenirlik Çalışması
Authors: BAĞCI ÇETİN Burcu , BULUŞ Mustafa
Published: August 2023

Bu çalışmada, Huebner (1994) tarafından geliştirilen ve 8-18 yaş aralığındaki bireylerin yaşam doyumu araştırmalarında kullanılan Çok Boyutlu Öğrenci Yaşam Doyumu Ölçeği’nin (Multidimensional Students’ Life Satisfaction Scale) Türk kültürüne uyarlaması yapılmıştır. Aydın ilinde okul öncesi eğitime devam eden 5-6 yaş grubu çocuklardan uygun örnekleme yöntemi kullanılarak belirlenmiş 931 çocuk örneklem grubunu meydana getirmektedir. Araştırmada açımlayıcı faktör analizi sonucunda, ölçeğin toplam varyansın %45,47’sini açıklayan tek faktör ve 9 maddeden oluştuğu sonucuna varılmıştır. DFA ile hesaplanan uyum istatistikleri dikkate alındığında, ölçeğin daha önce belirlenen 9 maddelik tek faktörlü yapısının bir model olarak doğrulandığı görülmüştür. Ölçeğin Cronbach alfa güvenirlik katsayısı 0,847 olarak hesaplanmıştır. Bu doğrultuda, Yaşam Doyumu Ölçeği (Çocuk Formu) olarak adlandırılan ölçme aracından elde edilen puanların geçerli ve güvenilir olduğu sonucuna varılmıştır.
International Transportation Projects and Türkiye from the Perspective of Transportation Economics
Authors: ÇELİKOK Kaan , TALİH Özgür
Published: August 2023

Today, the transportation industry is a service with global implications, one that must be assessed from a social, economic, and social perspective, and one that has a significant impact on national economies. The study, which focuses on these issues in-depth, offers a conceptual overview of transportation economics systems policies and strategies. It analyzes the economic impacts of international transportation projects on Türkiye and the broader region, using a transportation economics framework. The study could also aim to evaluate Türkiye's transportation policies and strategies and their potential to promote sustainable economic growth and development. It also adds to the literature by analyzing the impacts of similar projects like the Baku-Tbilisi-Kars Railway Project, the Belt and Road Project, the Black Sea Grain Initiative, the TÜRKSAT Communication Satellite Projects, and smart transportation on the potential overall national economy.
Politik Bir Mücadele Alanı Olarak Spor: Muhammed Ali Amerika’ya Karşı
Authors: ÇAKMAK Muhammet N.
Published: August 2023

Bu çalışmada spor-iktidar ilişkisi ünlü boksör Muhammed Ali örneği üzerinden incelenmiştir. Kitlelerin yeni afyonu olarak tanımlanan modern spor, iktidarla kurduğu bağımlılık ilişkisi nedeniyle ciddi eleştiriler almıştır. Lous Althusser bu anlamda sporu Devletin İdeolojik Aygıtı (DİA) olarak tanımlamıştır. Bunun yanında sporun iktidara karşı bir mücadele aracına dönüşebileceğini iddia eden çalışmalar ve örnek olaylar da mevcuttur. Bu çalışma modern sporun hem DİA hem de iktidar karşıtı bir araç olabileceği iddiasını taşımaktadır. Söz konusu iddiaya uygun olarak Muhammed Ali’nin hayatı nitel araştırma yöntemlerinden doküman analizi tekniğiyle incelenmiştir. Elde edilen bulgulara göre sporla modern iktidar arasında hayati sayılabilecek bir ilişki söz konusudur. Ancak bu ilişki pürüzsüz biçimde ilerlememektedir. İktidarın gücünü pekiştirmek adına kurguladığı spor, Ali örneğinde olduğu gibi iktidar aleyhine bir araca dönüşebilmektedir.
NucBarcoder - a bioinformatic pipeline to characterise the genetic basis of plant species differences v1
Authors: Huang Wu
Published: August 2023

There are now a significant number of studies that have sequenced multiple loci from the nuclear genomes of plants and these are available in public databases or in private data repositories (if the study hasn’t yet been published). Collectively these datasets have great potential for understanding the nature of genomic differences between plant species. To harness this existing information I have developed a set of workflows, with the logic behind our approach being to● Develop key criteria for selecting suitable datasets focusing only on datasets which have sampled multiple individuals from multiple congeneric species● Search the literature and public data repositories for datasets that match these criteria● Obtain and organise the selected datasets● Use these datasets to estimate the proportion of species that resolve as monophyletic units as one measure of species discrimination success● Establish the frequency distribution of taxonomically informative nucleotide substitutions among taxa to better understand the genomic nature of differences between plant species● Subsample the data to better understand the effectiveness of smaller numbers of loci in recovering maximal species discrimination, as well as evaluating the attributes of the gene regions that are most effective at telling species apart. This protocol will focus on the last three bullet points. For the protocol for the first three bullet points please refer to another protocol "Acquiring and integrating data from multiple resources for meta-analysis".
Rapid, high-throughput phenotypic profiling of endosymbiotic dinoflagellates (Symbiodiniaceae) using benchtop flow cytometry v3
Authors: J Anthony Colin
Published: August 2023

Endosymbiotic dinoflagellates (Family Symbiodiniaceae) are the primary producer of energy for many cnidarians, including corals. The intricate coral-dinoflagellate symbiotic relationship is becoming increasingly important under climate change, as its breakdown leads to mass coral bleaching and often mortality. Despite methodological progress, assessing the phenotypic traits of Symbiodiniaceae in-hospite remains a complex task. Bio-optics, biochemistry, or “-omics” techniques are expensive, often inaccessible to investigators, or lack the resolution required to understand single-cell phenotypic states within endosymbiotic dinoflagellate assemblages. To help address this issue, we developed a protocol that collects information on cell autofluorescence, shape, and size to simultaneously generate phenotypic profiles for thousands of Symbiodiniaceae cells, thus revealing phenotypic variance of the Symbiodiniaceae assemblage to the resolution of single cells. As flow cytometry is adopted as a robust and efficient method for cell counting, integration of our protocol into existing workflows allows researchers to acquire a new level of resolution for studies examining the acclimation and adaptation strategies of Symbiodiniaceae assemblages.
Acquiring and integrating data from multiple resources for meta-analysis v1
Authors: Huang Wu
Published: August 2023

Acquiring sequence data generated for various purposes and repurposing it to evaluate the nature of genomic differences between plant species requires thorough dataset assessments, efficient data processing, and careful management. In this chapter, I summarise the methodology for searching appropriate datasets, data collection and filtering, and data management. I provide examples of the data formats to guide future downloading and acquiring of the datasets, and the links to curated publicly available bioinformatic tools and self-written scripts to allow reproduction and reuse of this data acquiring and processing pipeline. There is now a significant number of studies that have sequenced multiple loci from the nuclear genomes of plants and these are available in public databases or in private data repositories (if the study hasn’t yet been published). Collectively these datasets have great potential for understanding the nature of genomic differences between plant species. To harness this existing information I have developed a set of workflows, with the logic behind my approach being to● Develop key criteria for selecting suitable datasets focusing only on datasets which have sampled multiple individuals from multiple congeneric species● Search the literature and public data repositories for datasets that match these criteria● Obtain and organise the selected datasets● Use these datasets to estimate the proportion of species that resolve as monophyletic units as one measure of species discrimination success● Establish the frequency distribution of taxonomically informative nucleotide substitutions among taxa to better understand the genomic nature of differences between plant species● Subsample the data to better understand the effectiveness of smaller numbers of loci in recovering maximal species discrimination, as well as evaluating the attributes of the gene regions that are most effective at telling species apart. This protocol will focus on the first three bullet points. The protocol for the rest of the bullet points please refer to another protocol "NucBarcoder - a bioinformatic pipeline to characterise the genetic basis of plant species differences".
gran depresión y el pensamiento económico mexicano detrás de las políticas gubernamentales
Authors: López-Martínez Jorge
Published: August 2023

En la actualidad, existe en México un debate público entre dos corrientes opuestas del pensamiento económico y político: el conservadurismo contra el liberalismo. El propósito de este artículo es analizar la confrontación análoga ocurrida en años previos y durante la gran depresión, que llevó a un cambio de ideas y políticas económicas en México, de las clásicas-neoclásicas, a las keynesianas. Para ello, se hace un minucioso análisis de las revistas Examen de las Condiciones Bancarias e Industriales, y la Revista Mexicana de Economía, y de la obra de Alberto J. Pani, Mi contribución al nuevo régimen. Se encontraron evidencias concretas de un cambio radical en 1932, de la política contraccionista a la expansionista, que dieron fin a la gran depresión –con cierta anticipación– en México.
Paseos, calzadas y jardines del Tepic porfiriano. El disfrute por la naturaleza en la ciudad
Authors: Ramos Delgado Raymundo
Published: August 2023

Las ciudades mexicanas decimonónicas, a raíz de las constantes epidemias y guerras que azotaron el país, incorporarían a su traza un conjunto de jardines públicos con la intención de mejorar el bienestar de su población. Es así que, bajo un discurso de higiene y moralidad, el espacio público empezó a ajardinarse de forma gradual por medio de un ambiente romantizado hacia lo verde, el cual incorporaba una estética de lo natural en lo humano, como un medio para las actividades que promovían el esparcimiento y la contemplación en lo urbano. En el presente artículo, desde la historiografía local y regional, se pretende advertir que los diversos espacios verdes públicos de la ciudad de Tepic durante el porfiriato respondieron en su origen a lo utilitario y, posteriormente, a partir de su apropiación, a lo simbólico y referencial.
Con España en el corazón. Redes subalternas entre México y Argentina durante la misión diplomática de Alfonso Reyes
Authors: Grossi Florencia
Published: August 2023

El presente artículo se propone explorar las relaciones diplomáticas entre México y Argentina durante la segunda misión diplomática del escritor mexicano Alfonso Reyes (1936 y 1937), momento en que la guerra civil española alcanzó un impacto transnacional. La indagación de las huellas registradas permite sugerir que las articulaciones, las redes y conexiones entre ambas naciones excedieron el espacio diplomático oficial constituyendo, lo que aquí se denomina, redes subalternas. Los desencuentros y oposiciones entre las cancillerías no sólo no impidieron que las relaciones internacionales se expandieran, sino que incluso las representaciones simbólicas sobre la política exterior de México, que se cristalizaron en la opinión pública argentina, actuaron como un factor adicional de legitimidad para el bando republicano en defensa de la España sitiada. En este entramado complejo e inestable, vislumbramos en la actuación de Reyes su dimensión más política y de escritor comprometido.
Efectos del tratamiento de semillas de frijol caupí Vigna unguiculata L. sobre el manejo de la marchitez vascular causada por Scleroctium rolfsii
Authors: Campo Arana Rodrigo Orlando , Burgos Ayala Pabla Rosa
Published: August 2023

El frijol caupí, es una leguminosa de importancia económica de los pequeños productores del Caribe, colombiano; sin embargo, la producción del grano es afectada por la marchitez vascular MV, causada por Scleroctium rolsii, ocasionando pérdidas hasta del 50 %. El objetivo de la investigación, fue evaluar el efecto del tratamiento de semillas en el manejo de la MV. Se establecieron dos experimentos, el primero se hizo en el laboratorio, determinando ingrediente activo y dosis que no afecte la emergencia y el desarrollo de las plántulas. El segundo se realizó en casa de mallas, donde las semillas fueron tratadas con las moléculas y la mejor dosis identificada en el primer experimento. El segundo experimento se estableció con la variedad Caupicor 50, bajo un diseño completamente al azar con cuatro repeticiones. Los tratamientos evaluados fueron los siguientes: T0: testigo absoluto, T1: Nitrato de calcio (1,0 g l-1), T2: Azoxystrobin + Difenoconazol (1,0 cc l-1); T3: Trichoderma harzianum, (3,0 g Kg-1); T4: Benomil (2,0 g Kg-1); T5: Carboxim + Thiram (2,0 g Kg-1); T6: fosfito de potasio (2,0 g L-1) y T7: testigo negativo, semillas sin protección. Las semillas de frijol tratadas, se sembrarán en suelo desinfectado y se inocularon con una cepa de Scleroctium folfsii. Cada cuatro días se realizaron evaluaciones de incidencia, severidad y altura. Los tratamientos más eficientes en el manejo de la MV, fueron T2, T3 y T5; sin embargo, el T2= Azoxystrobin+difecobazol, afectó la emergencia de las plántulas.
MiR-96-5p is involved in permethrin-promoted proliferation and migration of breast cancer cells
Authors: Yan Yi , Long Tian Wen , Niu Xi , Wang Jia Fu , Li Sheng
Published: August 2023

MicroRNAs (miRNAs) are major players in cellular responses to xenobiotic compounds and toxins. However, the role of miRNAs in pyrethroid pesticide-induced cancer progression remains unclear. This study aimed to investigate the function of miR-96-5p in permethrin-induced proliferation and migration in breast cancer cells. In our study, the expression of miR-96-5p was upregulated in permethrin-treated MCF-7 cells. MiR-96-5p promoted MCF-7 cell proliferation and migration, accompanied bychanges in the expression of proteins involved in cell proliferation, migration, and apoptosis. Homeobox A5 (HOXA5) was identified as a direct target of miR-96-5p. HOXA5 silencing had the opposite effects with miR-96-5p inhibition. In conclusion, these results suggest that miR-96-5p is involved in permethrin-promoted proliferation and migration of breast cancer cells by targeting HOXA5.
Адаптивные системы обучения
Authors: Акавова А.И.
Published: August 2023

В этой статье рассматривается текущее состояние систем адаптивного обучения и их потенциал для революционного изменения образовательных условий. В нем рассматриваются различные типы технологий адаптивного обучения, доступные сегодня, их использование в традиционных классах и онлайн-курсах, а также проблемы, связанные с внедрением. Наконец, в нем рассматривается, как эти системы могут повлиять на образование в ближайшие годы. Предоставляя обзор этой быстро развивающейся области, эта статья призвана обеспечить всестороннее понимание систем адаптивного обучения и их потенциального влияния на образование
Особенности дистанционного образования, его преимущества и недостатки
Authors: Смирнов В.М , Демкин А.М.
Published: August 2023

В статье рассматриваются вопросы современного российского дистанционного образования, его преимущества, недостатки и его влияние на процесс обучения
Avaliação da quantificação em orçamentos de obras através do método de modelagem BIM em oposição ao método convencional com desenhos 2D – Estudo de caso em um empreendimento de Capinzal/SC
Authors: Bortili Brian , Boesing Willian
Published: August 2023

O Building Information Modeling (BIM) tem a proposta de entregar a quem o utiliza, modelos virtuais do que será executado, diferentemente do que se propõe a plataforma CAD, sendo essa uma modalidade geralmente utilizada para modelagem de desenhos 2D. Tendo essa capacidade de se atribuir aos elementos que estão sendo modelados informações tais como as várias camadas de revestimentos utilizados em uma parede, cada qual com sua espessura, ou até mesmo o tipo e dimensões do madeiramento utilizado em uma estrutura de cobertura, o BIM pode nos entregar quantitativos muito mais assertivos em relação ao método 2D utilizado atualmente, além de proporcionar maior agilidade caso algum projeto precise ser alterado, pois quando o mesmo é modificado dentro da plataforma, as tabelas de quantificação são atualizadas instantaneamente. No presente trabalho, utilizou-se o software Revit 2020 versão estudante como software de modelagem do projeto em BIM extraindo do mesmo todas as informações referentes aos serviços com possibilidade de quantificação. A obra modelada foi um empreendimento residencial com dois blocos de apartamentos com quatro pavimentos cada, abrigando dois modelos de apartamentos do programa “Minha Casa Minha Vida”, sendo o primeiro com sala e cozinha integrada, 3 quartos, 1 banheiro e sacada, e o segundo com sala e cozinha integrada, 2 quartos, banheiro e sacada. Notou-se ao longo do projeto de pesquisa que houveram diferenças consideráveis em alguns itens, como a quantidade de alvenaria informada no orçamento da empresa a qual representava 280m² na quantificação CAD contra 3227m² do BIM, correspondendo a uma diferença quantitativa de 1052,50%. Essa diferença pode ser associada a falhas humanas na etapa de quantificação por meio do processo manual, com o auxílio dos desenhos em 2D feitos no software AutoCad, ou também falha no momento de digitação na planilha orçamentária. Foi possível constatar discrepâncias consideráveis também na parte dos revestimentos como cerâmica e reboco, estando associado à modelagem fidedigna no modelo BIM, o qual considera as alturas e áreas reais de revestimentos. Ao final podemos concluir que o BIM nos oferece uma maior assertividade no momento de extração dos quantitativos, porém é necessário salientar que a obtenção dos mesmos advém de uma correta modelagem por parte do projetista, buscando atentar-se a cada detalhe na alimentação das informações.
Differential diagnosis for multiple systemic inflammatory syndrome in children: clinical and laboratory clues
Authors: BICILIOĞLU Yüksel , NALBANT Tuğçe , ÇİÇEK Alper , ERGÖNÜL Esin , GÖKALP Gamze , DEMİR Gülsah , BARDAK Şefika , BERKSOY Emel
Published: August 2023

Objectives: We aimed to identify biochemical markers and clinical findings with high sensitivity and specificity that can be used in the differential diagnosis of patients suspected of having Multisystem Inflammatory Syndrome in Children (MISC) in the pediatric emergency department (PED). Moreover, we also examined early warning signs for predicting severe MIS-C patients requiring admission to intensive care unit (ICU).
Methods: We conducted a retrospective analysis of patients presenting to the PED with suspected MIS-C. Patient records were assessed for initial complaints, physical examination findings, laboratory and ımaging test results, diagnoses, and follow-up plans. Patients diagnosed with MIS-C were categorized as the MIS-C group, while others were categorized as the non-MIS-C group. Comparisons were made between these two groups.
Results: A total of 266 patients were included, with 68 diagnosed with COVID-19-associated MIS-C, including 20 monitored in the pediatric ICU. MIS-C patients had higher mean age, hospitalization, and ICU admission rates compared to non-MIS-C. MIS-C group showed higher prevalence of respiratory symptoms, hematological involvement, and shock. We observed lymphopenia, thrombocytopenia, hyponatremia, and elevated levels of blood C-reactive protein (CRP), procalcitonin, triglycerides, troponin, Brain Natriuretic Peptide (BNP), D-dimer, and fibrinogen in the MIS-C group. ICU patients had higher procalcitonin, aspartate aminotransferase, alanine aminotransferase, triglycerides, troponin, BNP, and ferritin levels, and lower sodium levels.
Conclusions: COVID-19-associated MIS-C group had higher rates of respiratory symptoms, hematological involvement, and shock. Lymphopenia, thrombocytopenia, elevated CRP, and D-dimer can guide MIS-C differential diagnosis. Additional tests (procalcitonin, troponin, BNP, triglycerides, ferritin) are recommended for high-suspicion cases. Patients with elevated BNP levels may require ICU admission.
Modulacja potencjało-zależnych kanałów jonowych Cat+ przez receptory dopaminergiczne
Authors: Rola Rafał , Szulczyk Paweł
Published: August 2023

Potencjałozależne kanały jonowe Ca++ to złożone z kilku podjednostek
białka błonowe odpowiedzialne za regulację przepływu jonów Ca++. Kanały te
są zamknięte w spoczynku i otwierają się pod wpływem depolaryzacji błony
komórkowej. Napływ jonów Ca++ do środowiska wewnątrzkomórkowego
moduluje cały szereg procesów komórkowych takich jak np.: przekazywanie
informacji, aktywację kinaz i fosfataz, aktywację ekspresji genów oraz
wydzielanie neurotransm iterów w zakończeniach synaptycznych [5,17,26].
Receptory dopaminergiczne działają za pośrednictwem aktywacji białek G, które
aktywując szereg wewnątrzkomórkowych szlaków transdukcji sygnału, których
jednym z efektorów są potencjałozależne kanały jonow e Ca++. W wyniku ich
aktywacji receptorów dopaminergicznych dochodzi do zmiany amplitudy,
szybkości aktywacji i inaktywacji prądów jonowych Ca++ co z kolei modyfikuje
aktywność neuronów lub zmienia uwalnianie przez nie neurotransmiterów
[5,12,15,19,25,27,28,31,28].
Wpływ pH na efekt modulacji aktywności kanałów potasowych Kvl .3 przez jony cynku
Authors: Teisseyre Andrzej , Mozrzymas Jerzy W.
Published: August 2023

Przy zastosowaniu techniki patch-clamp w konfiguracji whole-cell
prowadzono badania nad wpływem zewnątrzkomórkowego pH na efekt
modulacyjny wywierany na kanały Kvl.3 przez jony cynku. Stwierdzono, że
obniżenie pH z 7.35 do 6.8 spowodowało znaczące przesunięcie napięciowej
zależności aktywacji badanych kanałów w stronę dodatnich wartości potencjału
błonowego oraz zmniejszenie szybkości ich aktywacji. Stwierdzono też, że
obniżenie pH z 7.35 do 6.8 nie miało istotnego wpływu na przesunięcie
napięciowej zależności aktywacji kanałów Kvl.3 w stronę dodatnich wartości
potencjału błonowego, zmniejszenie amplitudy prądów potasowych oraz
spowolnienie ich aktywacji zachodzące podczas aplikacji jonów cynku
w stężeniu 100 цМ. Całkowite przesunięcie napięciowej zależności aktywacji,
jak również spowolnienie szybkości aktywacji kanałów pod wpływem działania
obydwu wyżej wspomnianych czynników było istotnie większe od zmian
spowodowanych przez aplikację jonów cynku bez zmiany pH. Generalnie,
otrzymane wyniki pokazały, że addytywne efekty modulacyjne wywierane na
kanały Kvl.3 przez jony cynku i protony mogą zachodzić przy wartościach
zewnątrzkomórkowego pH i przy stężeniach jonów cynku osiągalnych
w warunkach fizjologicznych.
Napięciowa zależność kinetyki prądów GABA ergicznych mierzonych przy różnych wartościach zewnątrzkomórkowego pH
Authors: Pytel Maria , Mercik Katarzyna , Mozrzymas Jerzy W.
Published: August 2023

Zmiany wartości napięcia błonowego i stężenia jonów wodorowych to
jedne z najbardziej powszechnych czynników modulujących układy biologiczne,
szczególnie komórki nerwowe. Wiele doniesień literaturowych wskazuje, że
zarówno potencjał błonowy jak i zmiana stężenia jonów wodorowych wpływają
na kinetykę prądów GABAergicznych, ale zagadnienie równoczesnej modulacji
przez oba te czynniki nie zostało zbadane. W niniejszej pracy dokonaliśm y opisu
wpływu napięcia błonowego i zewnątrzkomórkowego pH w zakresie od 6.0 do
8.0 na kinetykę receptora GABAa. Otrzymane wyniki wskazują na brak
istotnego wpływu napięcia na kinetykę odpowiedzi prądowych mierzonych
w kwaśnym pH, natom iast silna modulacja przez napięcie dotyczyła odpowiedzi
prądowych rejestrowanych w pH=7.2 i 8.0.
Układ 10-20 lokalizacji elektrod EEG czyli gdzie tkwi pewien błąd koncepcyjny
Authors: Stanisławczyk Andrzej , Zyss Tomasz , Sawicki Bartosz
Published: August 2023

Opisano problemy związane z definiowaniem położenia elektrod do badań
neurofizjologicznych w standardowym układzie 10-20. Przedstawiono
możliwości skonstruowanego przez siebie solwera softw are’owego.
Zaprezentowano propozycję zmodyfikowania zasad układu 10-20 - polegającą
na zastosowaniu tych samych odległości kątowych (ty: 22,5°) na wszystkich
osiach głowy XYZ.
Quality Characteristics of Chicken Meat Balls Incorporated with Pearl Millet (Pennisetum glaucum)
Authors: Santhi D. , . A.Kalaikannan , . A.Elango , Natarajan A.
Published: August 2023

Background: Pearl millet is rich in dietary fiber and micro-nutrients such as vitamins and minerals apart from the carbohydrates, protein and fat. This study was conducted to fortify low fat chicken meat balls with pearl millet (Pennisetum glaucum) as a dietary fibre source and to assess the physico-chemical, sensory and textural properties. Methods: Emulsion based low fat chicken meat balls were prepared with the addition of Pearl millet flour (PMF) at levels of 4%, 7% and 10%, over and above the amount of meat along with a control and analysed for physico-chemical, textural and sensory properties. Result: In the physico-chemical properties, Emulsion pH, product pH and emulsion stability were not affected by the addition of PMF. Product yield was significantly (P≤0.01) lowered at 4 per cent level of PMF, but increased at higher levels of PMF inclusion. In texture analyses, hardness and cohesiveness were not affected by inclusion of PMF up to 7%. In sensory evaluation, though the scores for texture, tenderness and overall acceptability of 4% treatment were comparable with that of control and significantly (P≤0.01) decreased with increase in the level of PMF, the scores for 7% treatment were above ‘Very acceptable’ level. It is concluded emulsion based functional low fat chicken meat balls could be fortified with pearl millet flour up to a level of 7% without affecting the quality characteristics.
Avaliação do impacto de treinamento on-line nos conhecimentos e atitudes de higiene de manipuladores de alimentos
Authors: Garcia Júnior Élcio Antônio , Rodrigues Noádia Priscila Araújo
Published: August 2023

Introdução: Os alimentos e bebidas podem transmitir doenças quando contaminados com micro-organismos patogênicos. Os manipuladores de alimentos devem ser conscientizados quanto às medidas de higiene e Boas Práticas. Objetivo: Analisar a eficácia de qualificação em higiene e segurança de alimentos por meio de plataforma digital. Metodologia: Foi aplicado um questionário antes e após treinamento realizado de forma online e assíncrona, por meio da utilização da plataforma Google Classroom®. Resultados: Inicialmente, o público-alvo detinha 86±1% de conhecimentos e atitudes adequados,  Após o curso, atingiu média de 98±5%. Os conhecimentos prévios sobre higiene e segurança alimentar eram satisfatórios, Porém, a abordagem digital demonstrou eficiência na educação sobre higiene pessoal, ambiental e no manejo seguro dos alimentos, incluindo preparo, descongelamento, contaminação e higienização de vegetais. Discussão: A utilização de cursos a distância, por meio de plataformas digitais, tem sido apresentada como um método eficiente para levar conhecimentos e modificar as atitudes relacionadas à segurança e higiene de alimentos para os profissionais do setor de alimentação. Conclusão: A utilização de plataforma digital para oferta de qualificação em higiene e segurança de alimentos demonstrou ser eficiente para aplicação dos conteúdos relacionados a forma correta de armazenamento, contaminação cruzada, higiene das mãos, saúde do manipulador e higiene do manipulador.
Spermiogramic parameters of Japanese quails (Coturnix coturnix japonica) to aqueous administration of egg lime molasses mixture
Authors: Akintunde Adeyinka Oye , Ndubuisi-Ogbonna Lois Chidinma , Ladele Mofiyinfoluwa M. , Olorunfemi Oladapo Ayodeji , Ojo Olayinka Abosede , Oyewumi Samson O. , Bolatito Adenike Shobo  , Olufunso Emmanuel Akinboye
Published: August 2023

As demand for animal protein rises, raising Japanese quail holds much potentials in bridging the gap. Phytogenics has been reported to have effect on spermiogramic parameters of animals. This research was done to ascertain the spermiogramic parameters of Japanese quails to administration of aqueous solution of egg lime molasses mixture (ELM). Fresh eggs were placed in a dish, followed by 500g of molasses and 1 liter of lime juice. It was then covered for 10 days and the entire mixture was blended. Two hundred day old Japanese quails were assigned to five treatments in a Completely Randomized Design and were subdivided into 4 replicates of 10 birds each. The control (T1) having no administration of ELM, T2 had an inclusion level of 10 mL, T3: 20 mL, T4: 30 mL and T5: 40 mL, all in 500 mL of water.  Feed and water were provided ad libitum. The study was carried out for 49 days. Data were collected on genitalia morphometry and fertilizing potentials. The birds administered 20 mL of ELM had significantly (p <0.05) higher left epididymis weight (0.36 ± 0.05g) compared to the other groups. The inclusion of ELM in the water significantly influenced (p <0.05) left epididymis volume, paired epididymis volume, left epididymis density, paired epididymis density and spermatozoa reserves in the right epididymis. Testosterone values significantly increased (p <0.05) with increased ELM inclusion. It can be concluded that the administration of ELM did not alter growth parameters however birds that received 20 mL per 500 mL of water had the best reproductive parameters.
Advanced and emerging radiation therapy approaches for intrahepatic cholangiocarcinoma
Authors: Thonglert Kanokphorn , Chuong Michael D. , Herrera Robert , Apisarnthanarax Smith
Published: August 2023

Radiotherapy (RT) is an integral component of the multidisciplinary care for intrahepatic cholangiocarcinoma (iCCA). Over the past decades, RT techniques have been developed with the aim of enhancing tumor control and minimizing toxicity. The most recent technological advancements include proton beam therapy (PBT) and magnetic resonance-guided radiotherapy (MRgRT). PBT is notable for its unique physical characteristics that allow for greater sparing of surrounding normal organs, especially the liver, from low to moderate doses of radiation. MRgRT provides advantages in other aspects, including superior tumor visualization before treatment, on-board treatment plan adaptation, and tumor tracking during treatment. These features allow for precise dose delivery and safe dose escalation, especially for patients with tumors close to luminal GI structures. In this review article, the rationale, clinical outcomes, clinical applications, challenges, and future directions of PBT and MRgRT are discussed. Additionally, the potential combination of novel therapeutics with RT in iCCA is explored.
Machine learning assisted intelligent design of meta structures: a review
Authors: He Liangshu , Li Yan , Torrent Daniel , Zhuang Xiaoying , Rabczuk Timon , Jin Yabin
Published: August 2023

In recent years, the rapid development of machine learning (ML) based on data-driven or environment interaction has injected new vitality into the field of meta-structure design. As a supplement to the traditional analysis methods based on physical formulas and rules, the involvement of ML has greatly accelerated the pace of performance exploration and optimization for meta-structures. In this review, we focus on the latest progress of ML in acoustic, elastic, and mechanical meta-structures from the aspects of band structures, wave propagation characteristics, and static characteristics. We finally summarize and envisage some potential research directions of ML in the field of meta-structures.
MODERN CRIMINALISTIC METHODS
Authors:   Faculty of security Skopje, Malish Sazdovska Marina , Sviderski Mihajlo
Published: August 2023

Criminalistic science uses scientific methods used in other scientific disciplines, but adapted to the specific needs of criminal investigation. Criminalistics also uses methods that are designed to be used exclusively for criminalistic purposes. Thus, methods of identifying persons by papillary line analysis, handwriting analysis using graphological methods, odor analysis, scene accident photography with stereo graphometry, comparative trace analysis with comparative microscope, photo robot creation software, and many other methods are applied in criminal investigations. However, new methods are being developed to improve the work of criminalists who work in the field of investigating, inspecting, alibi determination, tracing and material evidence for pre-trial and court proceedings, as well as other operational-tactical measures and investigative actions. Practical field work also applies methods of profiling persons, application of modern technological means of tracking persons and situations, such as drones, which are also used in criminal intelligence, methods of detection lies, etc. The authors of the paper analyze contemporary criminalistic methods with particular reference to their application in practical work when undertaking measures and activities within the framework of criminalistic methodology. Namely, in the process of elimination of crimes, special attention is paid to detection, proving, and clarification of crimes. Particularly important in this part are the criminalistic methods that answer the nine golden questions of criminalistic, and reveal the perpetrators. Key words: criminology, methods, investigations, traces, analysis, etc.
SOCIETAL DEVIANCE IN THE ERA OF DISTORTED VALUES AND NORMS: EUROPEAN AND MACEDONIAN PARALELS
Authors:   Faculty of Security - Skopje, Gerasimoski Saše
Published: August 2023

We are living in an era of turbulent social changes that affect our everyday life. The contemporary societal order has been put to pressures and exposed to challenges like never before in the history of human society. Many scholars believe that what we are witnessing nowadays is an era of value ambivalence and norm relativization that is intricately related to societal deviance. Many theories, classical, modern, and postmodern elaborate these phenomena. Such are the Emile Durkheim’s theory of anomie, Robert Merton’s theory of strain and Zygmunt Bauman’s theory of interregnum. In this paper, we are trying to elaborate those theories through the lenses of the distorted morals and values and the nexus with societal deviance in comparative European and Macedonian societal context. As far as methodology is concerned, we mainly use secondary data of available scientific literature and studies in the values and norms changes and its relatedness to societal deviance. We shall try to prove and elucidate the importance of the structural changes in values and norms and how they produce or are a product of societal deviance. Although mainly comparatively theoretical, the paper will try to overcome the possible limitations with its thorough comparative analyses of the most relevant scientific literature and research on this matter, mostly from sociological, socio-pathological, philosophical and securitological point of view. The paper will also try to summarize some relevant suggestions, proposals and recommendations on how to overcome these problems in European and Macedonian comparative perspective. Keywords: Societal Deviance, Values, Norms, Europe, Macedonia
THE NEED OF COOPERATION BETWEEN THE PRIVATE SECURITY COMPANIES AND THE STATE SECURITY SERVICES IN THE FIGHT AGAINST TERRORISM
Authors:   Law Faculty, Ilijevski Ice , Dimovski Zlate ,   Faculty of Security, Babanoski Kire
Published: August 2023

Terrorism is a global threat to the whole humanity, which has particularly negative and harmful consequences. Terrorist attacks, incidents, and actions are a form of security endangerment with varied and constantly changing ways of committing. The fight against terrorism is highly dependent on the efficiency of the measures and activities of the law enforcement agencies, their speed in detecting terrorist organizations, their preparatory actions and their response to a terrorist attack. This fight requires close co-operation between such entities in order to exchange information and timely detect illegal activities that precede terrorist acts. The main subject of this paper is to discuss the measures and activities of the private security companies and the state security services in preventing terrorist acts as well as taking action following a terrorist attack. The purpose of this paper is to present the current situation and future perspectives of cooperation between the security authorities, to raise the awareness of the important role that the private security sector plays, and to enhance its well-deserved position with other security authorities in the efficient functioning of the fight against terrorism. Keywords: terrorism, terrorist attacks, security authorities, cooperation, relations
ONTOLOGY OF SECURITY (APPENDIX TO THE ESTABLISHMENT AND DEVELOPMENT OF THE PHILOSOPHY OF SECURITY)
Authors:   Faculty of Security – Skopje, Mojanoski Cane , Arizankoski Goce ,   Criminologist- Ministry of Internal Affairs, Angjeleski Zlatko
Published: August 2023

Security sciences and scientific disciplines (as well as all natural and social sciences), depart from those philosophically determined basic principles that are grouped into theories of the being (existence) of security occurrences (ontology of security), for understanding of safety occurrences (gnoseology of security) and the values and valuation of safety occurrences (axiology of security), whereby presuppose the recognition and appreciation of security occurrences, and vice versa - the recognition of security occurrences presupposes the existence and valuation of what is known, and also the valuation assumes the existence of security occurrences and the methodological and methodological possibility of their recognition. On the aforementioned philosophical basis and methodological direction - our philosophical, i.e., ontological analysis and synthesis of security (as an idea, condition, value, need, interest, function, organization and system) begins with the long-known ontological fact that security as a practice is as old as the human race, arising from the materialization of human emotions and the urge for selfpreservation (the instinct of fear and the biological mechanism of survival of the organism), and the assumptions that man's first thoughts were utterly practical, that is, life itself had to be safe first and foremost - food, heat, protecting against catastrophes and avoiding danger were the first goals of reason, but also a longestablished anthropological finding that the need for protection, security and safety 80 is based on the basic natural laws of the struggle for existence - a sufficiently firm basis for the fact that the need for safety and security is one of the basic needs of people. In this paper we are making an effort to try and open up a debate regarding ontology of security as a separate philosophical discipline aimed at the continuous acquisition and promotion of a reference framework of chronological, current and anticipatory knowledge of the importance, the being and the idea of security (as a condition, value, need, interest, function, organization and system), as well as on the basis of security on the necessity, determinacy, continuity, importance and development of the social-security existence (human being) and humanity as an emergent form of it existence by virtue of its enduring, existential and natural-social need for security. Keywords: ontology of security, importance of security, being of security, idea for security.
SEMANTIC ANALYSIS OF THE ENGLISH TERMS “WHISTLEBLOWER” AND “WHISTLEBLOWING” AND THEIR TRANSLATIONAL EQUIVALENTS IN MACEDONIAN AND SOME OF ITS RELATED LANGUAGES
Authors:   Faculty of Security Skopje, Trajkovska Vesna
Published: August 2023

histleblowing and their official translational equivalents in Macedonian. It addresses the notions lexicalized by the original English terms whistleblower and whistleblowing and the challenges of the transfer of their semantic content into Macedonian. Furthermore, the paper provides a comparative analysis of the Macedonian translational equivalents and the official equivalents of whistleblower and whistleblowing in Serbian, Croatian, Bosnian, Slovenian and Montenegrin, with reference to the original English terms. It aims at detecting the translation strategies employed when choosing the translational equivalents in the given languages, as they are encountered in official legal documents regulating the area that the notions whistleblower and whistleblowing refer to. Key words: whistleblower, whistleblowing, Macedonian, English, translation