bluuebunny/crossref_metadata_2025 huggingface dataset:
Meningkatkan Berpikir Kritis Siswa melalui Media Pembelajaran Flipbook berbasis Kasus pada Muatan IPA Kelas V SD
Authors: Landina I. A. P. L. , Agustiana I. G. A. T.
Published: February 2023

Keterbatasan pemahaman guru dalam membuat media pembelajaran saat daring serta belum adanya penanaman konsep pada muatan IPA menyebabkan siswa kurang dapat berpikir kritis sehingga tujuan pembelajaran belum tercapai sepenuhnya. Maka, dibutuhkan media pembelajaran yang dapat mengatasi permasalahan tersebut agar kegiatan pembelajaran dapat optimal. Tujuan penelitian ini untuk menciptakan media pembelajaran berupa flipbook berbasis kasus untuk siswa kelas V SD. Jenis penelitian adalah pengembangan dengan menggunakan model ADDIE. Subjek penelitian terdiri dari 2 ahli materi, 2 ahli media, 2 praktisi, 6 orang uji coba kelompok kecil, dan 3 orang siswa uji coba individu. Teknik analisis data menggunakan deskriptif kuantitatif dan kualitatif dengan metode wawancara, observasi, dan angkat/kuesioner untuk pengumpulan data. Hasil dari penelitian yaitu ahli materi mendapatkan rata-rata 4,3 dengan kualifikasi sangat baik, ahli media memperoleh rata-rata skor 4,6 dengan kualifikasi sangat baik, praktisi memperoleh rata-rata skor 4,8 dengan kualifikasi sangat baik. Uji coba kelompok kecil memperoleh rata-rata skor 4,4 dengan kualifikasi sangat baik, uji coba individu dengan rata-rata skor 4,5 dengan kualifikasi sangat baik. Jadi, disimpulkan bahwa media pembelajaran flipbook layak dan valid untuk digunakan dalam proses pembelajaran.
Gender And Workplace Associated With Psychosocial Status Of Nursing Population In Third Month Covid-19 Outbreak
Authors: Hapsah Hapsah , Anna AS A Nur , Rasmawati Rasmawati , Wahyuni Wahyuni , Harun Basmalah
Published: February 2023

Health care professionals have a higher risk of contracting Covid-19 with high stress, overwork, sometimes without proper training and personal protective equipment. Gender, occupation and workplace were factors affected to cope stress ability in person daily life. Aim of this study was to identify association between gender and workplace with psychosocial status on 920 mental health nursing seminar participants in the first three months of Covid-19 outbreak in various Indonesian regions. Accidental sampling was conducted an hour before the Indonesian National Nurses Association of South Sulawesi started the seminar with The Self-Reporting Questionnaires (SRQ29) online form with informed consent. There were 920 of 1500 participants filled the form. Variable association was analyzed by using Pearson Chi Square and Fisher Exact Test. The results show that based on gender, women significantly dominated anxiety symptom, somatic symptom, decreased energy symptom and post traumatic stress symptom Workplace significantly associated with depression symptom, cognitive symptom, psychotic symptom and post traumatic stress symptom which dominate in college. Gender and workplace were associated with psychosocial symptom. Therefore, it is essential for further research to arrange strategies for minimizing those symptoms.
Correlation Mother’s Eduaction and Received Stunting Information with Mother’s Stunting Knowledge
Authors: Rahmah Ayyida Aini , Yani Desy Indra , Eriyani Theresia , Rahayuwati Laili
Published: February 2023

Inadequate nutritional intake in toddlers is one of the main causes of stunting. Mother’s knowledge will determine attitudes in maintaining the nutritional needs of toddlers, and reducing the potential for stunting in toddlers. Factors that influence knowledge are education and information. The aim of the study was to analyze the correlation between mother’s education level and received stunting information with mother’s knowledge of stunting in Desa Sukamulya, Bandung Regency. The research design is a correlational quantitative, secondary data approach. The population is mothers with toddler in Desa Sukamulya, Bandung Regency. Samples were taken using total sampling technique, totaling 55 people. The instrument consisted of mother’s education, received stunting information, and mother’s stunting knowledge. The statistical test will be used Chi square. The results showed that there was no correlation between the mother’s education level (p-value = 0.138) and information exposure (p-value = 1.000) and the mother’s knowledge of stunting. Implementation of health education with audio-visual media and booklets as well as information guidance through health cadres can be carried out by community nurses to increase public knowledge regarding stunting. Education level and information exposure were not related to knowledge about stunting in Sukamulya Village, Bandung Regency. Community knowledge can be increased through the provision of health education interventions. Further research still needs to be done with better methods by use primary data.
Le Couloir, la strate, le labyrinthe et le tableau. L’espace et l’observateur dans Passion de J.-L. Godard
Authors: Fontanille Jacques
Published: February 2023

Le « couloir », la « strate », le « labyrinthe » et le « tableau » sont les quatre formes principales de l'espace en profondeur dans Passion, de J.-L. Godard. Leur identification commence par une étude de la profondeur de champ et des différentes formes qu'elle prend dans ce·film; mais elle débouche très vite sur celle de leur fonction esthétique, et des valeurs qui sous-tendent cette esthé­ tique.
Detection of fibril nucleation in micrometer-sized protein condensates and suppression of Sup35NM fibril nucleation by liquid-liquid phase separation
Authors: Fukuyama Mao , Nishinami Suguru , Maruyama Yoko , Ozawa Taiki , Tomita Shunsuke , Ohhashi Yumiko , Kasuya Motohiro , Gen Masao , Chatani Eri , Shiraki Kentaro , Hibara Akihide
Published: February 2023

Elucidating the link between amyloid fibril formation and liquid–liquid phase separation (LLPS) is crucial in understanding the pathologies of various intractable human diseases. However, the effect of condensed protein droplets generated by LLPS on nucleation (the initial step of amyloid formation) remains unclear because of the lack of available quantitative analysis techniques. This study aimed to develop a measurement method for the amyloid droplet nucleation rate based on image analysis. We developed a method to fix micrometer-sized droplets in gel for long-term observation of protein droplets with known droplet volumes. By combining this method with image analysis, we determined the nucleation dynamics in droplets of a prion disease model protein, Sup35NM, at the single-event level. We found that the nucleation was unexpectedly suppressed by LLPS above the critical concentration (C*) and enhanced below C*. We also revealed that the lag time in the Thioflavin T assay, a semi-quantitative parameter of amyloid nucleation rate, does not necessarily reflect nucleation tendencies in droplets. Our results suggest that LLPS can suppress amyloid nucleation, contrary to the conventional hypothesis that LLPS enhances it. We believe that the proposed quantitative analytical method will provide insights into the role of LLPS from a pathological perspective
Nickel-Catalyzed Direct Stereoselective Alpha-Allylation Ketones with Non-conjugated Dienes
Authors: Cao Yi-Xuan , Wodrich Matthew , Cramer Nicolai
Published: February 2023

The development of efficient, sustainable methods for the construction of carbon-carbon bonds with the simultaneous stereoselective generation of vicinal stereogenic centers is a longstanding goal in organic chemistry. In this respect, the carbonyl group is a particularly relevant due to its ability reacting either as electrophile or pro-nucleophile at the alpha-carbon in its enolized form. The transition from precious metals to catalysts based on earth-abundant metals made impressive progress, and especially nickel became a powerful tool due to its low-cost and unique reactivity profiles. Low-valent nickel(0) complexes promote reductive couplings carbonyl compounds exploiting the electrophilic nature of the carbonyl group. In stark contrast, complementary alpha-functionalization of carbonyls leveraging its pro-nucleophilic character in conjunction with olefin acceptors are very scarce despite their attractivity. We report a Ni(0)NHC catalyst which promotes the conversion of ketones and non-conjugated dienes that are both cheap and widely accessible starting materials to synthetically highly valuable alpha-allylated products in excellent yields under mild conditions without any additional base or additive. The catalyst directly activates the alpha-hydrogen atom of the carbonyl substrates transferring it the olefin acceptor. The complete process is redox neutral and fully atom-economic. This feature contrasts typical carbonyl -functionalizations with precious metals that require functionalized substrates like a pre-formed enolate nucleophile and allyl electrophile. The transformation creates adjacent quaternary and tertiary stereogenic centers in a highly diastereoselective manner. Moreover, we introduce a chiral bulky designer NHC ligand allowing to conduct the reaction in an enantioselective manner providing the functionalized products with up to 99:1 er and >20:1 dr. Mechanistic and computational studies indicate an initial LLHT process from the ketone substrate to the olefin substrate to set the selectivity of the whole transformation. A beta-hydride elimination chain walking events is triggered until a favorable pi-allyl intermediate is reached leading by reductive elimination to the targeted products. The shown facile and selective functionalization of alpha-C-H bond of carbonyl groups by Ni(0)NHC catalysts opens new opportunities to exploit sustainable 3d-metal catalysis for a stereoselective access to valuable chiral building blocks.
Marshmallow-like macroporous silicone monoliths as reflective standards and high solar-reflective materials
Authors: Hayase Gen
Published: February 2023

A surfactant-free acetate-triethanolamine two-step catalytic sol-gel process with varying solvent content prepared marshmallow-like macroporous silicone monoliths. The resulting gels had fewer bubbles and other defects than conventional preparation methods. These materials exhibited high total reflectance of over 95.0 % in the visible light region. Samples with optimized solvent-to-precursor ratios show absolute reflectance greater than 97.5 % at 400 nm-1100 nm and can be used in place of reflectance standards. Unlike existing reflectors, macroporous silicon monoliths are bulk materials that can be fabricated in a single reaction, allowing them to be large-area and arbitrarily shaped. These materials can be used not only for indoor measurements but also for outdoor telemetry applications such as drones and robots. They also exhibit excellent solar reflectance and significant absorption suppression over the entire wavelength range of sunlight. Their water repellency, UV resistance, low thermal conductivity, and efficient radiative cooling properties make them an ideal material for outdoor thermal management. The results of this study suggest that macroporous silicon monoliths have potential for use as a highly solar-reflective material that can successfully control surface temperature rise while contributing to environmental concerns.
Improving Compound-Protein Interaction Prediction by Self-Training with Augmenting Negative Samples
Authors: Koyama Takuto , Matsumoto Shigeyuki , Iwata Hiroaki , Kojima Ryosuke , Okuno Yasushi
Published: February 2023

Identifying compound-protein interactions (CPIs) is crucial for drug discovery. Because experimentally validating CPIs is often time-consuming and costly, computational approaches are expected to facilitate the process. Rapid growths of available CPI databases have accelerated the development of many machine learning methods for CPI predictions. However, their performance, particularly their generalizability against external data, often suffers from a data imbalance attributed to the lack of experimentally validated inactive (negative) samples. In this study, we developed a self-training method for augmenting both credible and informative negative samples to improve the performance of models impaired by data imbalances. The constructed model demonstrated a higher performance than those constructed with other conventional methods for solving data imbalances, and the improvement was prominent for external datasets. Moreover, examination of the prediction score thresholds for pseudo-labeling during self-training revealed that augmenting the samples with ambiguous prediction scores is beneficial for constructing a model with high generalizability. The present study provides guidelines for improving CPI predictions on real-world data, thus facilitating drug discovery.
Impact of Covid-19 Pandemic on Ministry of Religious Affairs Policy in Entrepreneurial Development of Pondok Pesantren
Authors: Fatmawati Fatmawati , Mulazid Ade Sofyan
Published: February 2023

This study aims to analyze the impact of the Covid-19 pandemic on the Ministry of Religious Affairs policies in the development of entrepreneurial pondok pesantren (Islamic boarding schools). This research method used a qualitative descriptive approach. The primary data source comes from interviews and activity reports obtained directly from the office of the Directorate of Diniyah Education and Pondok Pesantren of the Ministry of Religious Affairs and other relevant documentation. Data analysis techniques used descriptive qualitative analysis, intended to find out the social reality of the Ministry of Religious Affairs as policymakers of entrepreneurial pondok pesantren assistance programs affected by the Covid-19 pandemic that was constructed by the mass media through advertising creators and newsmakers. The results showed that the Covid-19 pandemic also affected the economic life of the Islamic boarding schools. Hence, policies and strategic measures were needed to develope vocational life skill education programs designed to support the sustainable progress of business units at the schools. The entrepreneurial and vocational life kills of Islamic boarding schools movement initiated by the Ministry of Religious Affairs in collaboration with Bank Indonesia has broader implications on aspects of the reach of ummah economic empowerment and the economic independence of the Islamic boarding schools improved the welfare of the surrounding community. Penelitian ini bertujuan untuk menganalisis dampak pandemi Covid-19 terhadap kebijakan Kementerian Agama dalam pengembangan entrepreneurial pondok pesantren. Metode penelitian ini menggunakan pendekatan kualitatif deskriptif. Sumber data primer berasal dari wawancara dan laporan kegiatan yang diperoleh langsung dari kantor Direktorat Pendidikan Diniyah dan Pondok Pesantren Kementerian Agama, serta dokumentasi lainnya yang relevan. Tehnik analisis data menggunakan analisis kualitatif deskriptif, dimaksudkan untuk mengetahui realitas sosial Kementerian Agama sebagai pengambil kebijakan program bantuan entrepreneurial pondok pesantren terdampak akibat pandemi Covid-19 yang dikonstruk media massa melalui pencipta iklan dan pembuat berita. Hasil penelitian menunjukan bahwa pandemi Covid-19 ikut berpengaruh pada kehidupan ekonomi pondok pesantren, sehingga diperlukan kebijakan dan langkah-langkah strategis dalam megembangkan program pendidikan lifeskill vokasional pondok pesantren yang dirancang untuk mendukung kemajuan unit bisnis pesantren secara berkelanjutan. Gerakan entrepreneurial dan pendidikan lifeskill vokasional pondok pesantren yang digagas Kementerian Agama bekerjasama dengan Bank Indonesia ini, memiliki implikasi yang lebih luas pada aspek jangkauan pemberdayaan ekonomi umat dan kemandirian ekonomi pesantren, serta peningkatan kesejahteraan masyarakat sekitar.
Reconstruction of Maqâshid al-Syarî`ah As an Approach to Constitutional Law in Overcoming Crime in Indonesia
Authors: Suparmin Sudirman , Ramadani Ramadani
Published: February 2023

In Indonesia, the crime rate still reaches 1.01% in 2020, but crime still exists and is a state concern. The purpose of this study is aimed to analyze the offer of maqâshid al-syarî`ah as a solution in overcoming crime in Indonesia. This study is qualitative research in nature with a literature review approach. The object analyzed is Article 29 of UUD 1945 which is analyzed with the concept of maqâshid al-syarî`ah in the study of Islamic law. The results of this study describe that the maqashid sharia concept can be a solution to overcome crime in Indonesia as its concept regulates various things including God's purposes (qashdu al-syâri') and mukallâf goals (qashdu al-mukallâf) as well as the perspective of constitutional law in the crime in Indonesia. The state regulates matters contained in the state of the fundamental norm, namely the constitution contained in Article 29 of UUD 1945. This article uses a religious approach as a basic rule to regulate the life of the Indonesian legal community so that they live a good life and do not commit the crimes contained in the UUD 1945. Internalization of maqâshid al-syarî`ah in constitutional law is an alternative to protecting citizens from various crimes. Di Indonesia, angka kejahatan masih mencapai 1.01% pada tahun 2020,  artinya kejahatan masih ada dan menjadi perhatian negara. Tujuan penelitian ini adalah menganalisis tawaran  maqashid syariah sebagai solusi dalam mengatasi kejahatan di Indonesia. Penelitian ini merupakan penelitian kualitatif dengan pendekatan kajian pustaka. Objek yang dianalisis adalah  pasal 29 UUD 1945 yang dianalisis dengan konsep maqâshid al-syarî`ah dalam kajian hukum Islam. Hasil penelitian ini menguraikan bahwa konsep maqâshid al-syarî`ah dapat menjadi solusi untuk mengatasi kejahatan di Indonesia sebagaimana konsep maqashid syariah mengatur berbagai aspek diantaranya yaitu tujuan Allah (qashdu al-syâri’) dan tujuan mukallâf (qashdu al-mukallâf) dan begitu juga dengan perspektif hukum tata negara dalam melihat kejahatan di indonesia. Negara mengatur hal yang terdapat pada staats fundamental norm, yaitu konstitusi yang terdapat di dalam UUD 1945 pasal 29. Pasal ini menggunakan pendekatan agama sebagai aturan dasar untuk mengatur tata kehidupan masyarakat hukum Indonesia agar menjalankan kehidupan dengan baik dan tidak melakukan kejahatan sebagaimana yang tertuang di dalam UUD 1945. Internalisasi maqâshid al-syarî`ah dalam hukum tatanegara menjadi alternatif dalam menjaga warga negara dari berbagai kejahatan.
Criminal Provisions in Government Regulation Number 9 of 1975 According to Law Number 12 of 2011
Authors: Zulham Zulham , Pagar Pagar , Latip Muhammad
Published: February 2023

This paper aims at explaining the criminal provisions in government regulation number 9 of 1975, according to Law Number 12 of 2011. The research method used in conducting this article is a qualitative research method with a normative juridical research type using the statute approach. Sources of data are divided into two forms, namely primary data sources obtained directly from main sources such as the head of the Regional Office of the Ministry of Religions of the Republic of Indonesia, Commission III of the House of Representatives of the Republic of Indonesia, the Head of the High Court of Religion of North Sumatra, and experts in the field of Islamic law. In addition, laws and regulations and the book of ushul fiqh are used as secondary materials. Data analysis was carried out in the stages of data reduction, data presentation, and conclusion. The results show that the criteria for marriage that can be punished or fined are divided into two, namely First, is the presence of intention. Second, the action is detrimental to another person, in other words, the injured person reports or complains about the detrimental action to the police so that it can be processed because the provision is a complaint offense. Tulisan ini bertujuan untuk menjelaskan ketentuan pidana dalam peraturan pemerintah nomor 9 tahun 1975 menurut Undang-Undang Nomor 12 Tahun 2011. Adapun metode penelitian yang digunakan dalam penulisan artikel ini adalah metode penelitian kualitatif dengan Jenis Penelitian yuridis normative menggunakan pendekatan statute approach. Sumber data terbagi pada dua bentuk yaitu sumber data primer yang diperoleh langsung dari sumber utama seperti kepala kanwil Kementerian Agama RI, Komisi III DPR RI, Ketua Pengadilan Tinggi Agama Sumatera Utara, dan pakar dibidang hukum Islam. Selain itu, Peraturan perundang-undangan dan kitab ushul fiqih dijadikan sebagai bahan sekunder. Analisis data dilakukan dengan tahapan reduksi data, penyajian data, dan kesimpulan. Hasil penelitian menunjukkan bahwa kriteria pernikahan yang dapat dipidana atau didenda terbagi kepada dua, yaitu ; Pertama, adalah adanya niat atau unsur kesengajaan. Kedua, tindakan tersebut merugikan orang lain, dengan kata lain, bahwa orang yang dirugikan tersebut melaporkan atau mengadukan perbuatan yang merugikannya kepada pihak kepolisian, sehingga dapat diproses, karena ketentuan tersebut merupakan delik aduan.
The Challenges of Madrasah Management in Achieving Sustainability and Advantages in the Technological Digital Era
Authors: Luneto Buhari
Published: February 2023

This paper aims to discuss the problems faced in managing madrasas, particularly  in achieving high competitiveness in the current era of digital technology. This study uses exploratory descriptive data according to the theme and research objectives. The research data were analyzed through  in-depth evaluation and interpretation of the data, so that relevant important points were found related to the discussion of challenges and competitiveness faced by school management in modern times. This study found that the governance of Islamic schools faces various challenges, due to the fact that technology and the digital era are globalization trends that have positive and negative impacts. Madrasas as places where the pillars of Islam are in achieving educational goals based on Islam are expected to be able to take advantage of all these technologies by well, namely by balancing and aligning globalization trends, so as to give birth to creativity and active learning for students in facing competitiveness in today's global world. Tulisan  ini bertujuan untuk membahas permasalahan yang dihadapi dalam mengelola madrasah khususnya dalam mencapai daya saing yang tinggi di era teknologi digital saat ini. Penelitian ini menggunakan eksplorasi data deskriptif sesuai dengan tema dan tujuan penelitian. Data penelitian dianalisis dengan evaluasi mendalam, dan menginterpretasi data sehingga ditemukan poin-poin penting yang relevan terkait dengan pembahasan mengenai tantangan dan daya saing yang dihadapi oleh manajemen sekolah di zaman modern. Kajian ini menemukan bahwa tata kelola sekolah Islam menghadapi berbagai tantangan, disebabkan karena teknologi dan era digital  ini merupakan trend globalisasi yang memiliki dampak positif dan negatif. Madrasah sebagai tempat pilar Islam dalam mencapai tujuan pendidikan yang berlandaskan  agama Islam diharapkan bisa memanfatkan semua teknologi tersebut dengan baik, yaitu dengan cara menyeimbangkan dan menyelaraskan trend globalisasi, sehingga melahirkan kreatifitas dan pembelajaran aktif bagi siswa dalam menghadapi daya saing didunia global saat ini.
Exploring Students’ Higher Order Thinking Skills (HOTS): Best Practice in 13 Curriculum at Islamic High School in Bengkulu
Authors: Riswanto Riswanto
Published: February 2023

In order to apply what has been learnt in a contemporary situation, Higher Order Thinking Skills (HOTS) serve as a metaphor for transferring knowledge and skills. Curriculum 2013 places emphasis on these diverse higher order thinking processes. This study intended to examine what challenges students at Islamic High School in Bengkulu had while using HOTS to answer questions about reading and what caused them to still make mistakes in this situation. The research was descriptive in nature. Techniques of data collection subsumed observation, interviews, and documentation. The results demonstrated that the students still struggled with word misinterpretation at the analysis stage. They had a hard time understanding the information in the provided text during the evaluating stage, and they also struggled to analyze the questions’ intentions. The students had a hard time coming up with concepts for new items during the creation stage. The second discovery demonstrated that the elements such as time, students’ mastery, students’ learning abilities, and the learning environment should all be taken into account. This study concluded that some of these issues, including obstacles, may be to blame for students' poor aptitude for solving HOTS-based problems. This study contributes to providing English academicians with the demographic picture of students’ challenges and factors related to HOTS. Untuk menerapkan apa yang telah dipelajari dalam situasi kontemporer, keterampilan berpikir tingkat tinggi berfungsi sebagai metafora untuk mentransfer pengetahuan dan keterampilan. Kurikulum 2013 menekankan pada beragam proses berpikir tingkat tinggi ini. Penelitian ini bermaksud untuk mengkaji tantangan apa yang dimiliki siswa Madrasah Aliyah Bengkulu saat menggunakan HOTS untuk menjawab pertanyaan tentang membaca dan apa yang menyebabkan mereka masih melakukan kesalahan dalam situasi tersebut. Penelitian ini bersifat deskriptif. Metode pengumpulan data kualitatif meliputi observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa subjek masih berkutat dengan kesalahan interpretasi kata pada tahap analisis. Individu kesulitan memahami informasi dalam teks yang disediakan selama tahap evaluasi, dan mereka juga berjuang untuk menganalisis maksud pertanyaan. Ketiga subjek mengalami kesulitan untuk menghasilkan konsep item baru selama tahap pembuatan. Penemuan kedua adalah bahwa unsur-unsur seperti waktu, penguasaan siswa, kemampuan belajar siswa, dan lingkungan belajar semuanya harus diperhitungkan. Peneliti dapat menarik kesimpulan bahwa beberapa masalah ini, termasuk hambatan, mungkin menjadi penyebab rendahnya kemampuan siswa dalam memecahkan masalah berbasis HOTS. Penelitian ini memeberikan akademisi Bahasa Inggris tentang gambaran demografi terkait tantangan dan faktor HOTS siswa.
KAJIAN PENGARUH PENGEMBANGAN SISTEM FITOSOM TERHADAP AKTIVITAS AGEN SITOTOKSIK HERBAL
Authors: Priani Sani Ega
Published: February 2023

Prevalensi dan morbiditas penyakit kanker terus meningkat. Pencarian agen sitotoksik baru terus dilakukan termasuk yang berasal dari bahan alam. Pengembangan sistem penghantaran untuk meningkatkan aktivitas sitotoksik banyak dilakukan seperti dengan pembentukan  fitosom,  salah satu sistem nanovesikular. Tujuan dari penelitian ini adalah untuk mengkaji pengembangan bahan-banan herbal dengan sistem penghantaran fitosom dan juga mengetahui pengaruhnya terhadap aktivitas sitoksik dari senyawa bahan alam tersebut. Penelitian dilakukan dengan melakukan kajian literatur dari artikel yang berasal dari database bereputasi yang memenuhi kriteria inklusi dan eksklusi sesuai tujuan penelitian. Dari hasil kajian  diketahui bahwa sistem fitosom sudah banyak dikembangkan untuk penghantaran agen sitoksik herbal seperti pada ekstrak aloe vera, celastrol, curcumin, curcuminoid, diosgenin, icariin, genistein, lycopene, mytomicin, propolis, silibinin, sinigrin, dan thymoquinone. Fitosom diformulasikan dengan menggunakan fosfatidilkolin pada perbandingan fitokonstituen: fosfolipid yakni 1:(1-3), dengan atau tanpa penambahan kolesterol. Pengembangan sediaan fitosom terbukti mampu meningkatkan aktivitas sitotoksik bahan herbal baik berdasarkan pengujian in-vitro atau in-vivo. Pada pengujian in-vitro peningkatan aktivitas ditandai dengan penurunan nilai IC50 dengan tingkat penurunan yang bervariasi dalam rentang 1,7-11 kalinya. Ukuran partikel yang lebih kecil dengan struktur fosfolipid bilayer diketahui menjadi penyebab utama terjadinya peningkatan aktivitas tersebut. Dari hasil kajian disimpulkan bahwa sistem fitosom potensial untuk mampu meningkatkan aktivitas sitotoksik senyawa herbal.
Custo no uso de curativo a vácuo em um hospital no sul de Santa Catarina
Authors: Hoepers Neiva Junkes , Souza Gabriel Pereira de , Dagostin Valdemira Santina , Madeira Eduarda Bernardo , Mendes Aneas Belmiro , Zugno Paula Ioppi
Published: February 2023

Objetivo: caracterizar custo de curativo a vácuo como nova tecnologia em tratamentos de feridas em um hospital na região sul de Santa Catarina. Método: estudo de natureza quali-quantitativa, descritiva, composta por 12 prontuário eletrônico de paciente (PEP) do ano de 2020, realizada no mês de setembro de 2021. Resultados: nos PEP, foram encontrados 06 homens (50%) e 6 mulheres (50%) com idade que varia de 36 a 95 anos, sendo 08 deles(70%) idosos. Sendo que 09 destes apresentaram feridas em membros inferiores e 03 em outras regiões do corpo. O tempo de tratamento dos pacientes, variou de 6 a 28 dias. Discussões: o curativo a vácuo é efetivo diante feridas complexas, reduz o tempo de hospitalização do paciente, reduz o custo hospitalar para a instituição. Considerações finais: o paciente terá muitos benefícios com a utilização do curativo a vácuo, visto que diante desta pesquisa foram encontrados resultados positivos quando comparados o custo com seus benefícios.
Cuidados paliativos e sofrimento mental em pessoas idosas: revisão integrativa - saúde mental e cuidados paliativos
Authors: Friestino Jane Kelly Oliveira , Freitas Denise Cuoghi de Carvalho Veríssimo , Cazetta Aldenice Paes de Melo , Rossetto Maíra , Conceição Vander Monteiro da , Rezende Roseli
Published: February 2023

Objetivo: analisar as evidências da literatura acerca das possibilidades de cuidados paliativos as pessoas idosas em sofrimento psíquico desenvolvidas por equipes multiprofissionais. Métodos: revisão integrativa desenvolvida a partir da identificação, análise, e síntese do conhecimento produzido pela literatura. Os dados foram coletados nas bases de dados MEDLINE, LILACS, IBECS, PubMed e SciELO. Incluíram-se 12 artigos para revisão e síntese do conhecimento, os quais resultaram 04 categorias temáticas. Resultados: dentre as abordagens identificadas, encontram-se: reconhecimento dos sinais e sintomas para tratamento precoce; implementação de diretrizes práticas para os cuidados paliativos; conhecimento das especificidades do cuidado paliativo articulado em Redes, incluindo a comunicação e o conforto para melhorias na qualidade de vida. Conclusões: reconhecimento precoce dos sinais; diretrizes práticas no tratamento e efetivação de boa comunicação, foram evidenciados na revisão. O cuidado realizado por equipe multiprofissional encontra-se ainda em consolidação.
Development and validation of spectroscopic simultaneous equation method for simultaneous estimation of Azelnidipine and Valsartan in synthetic mixture
Authors: Harshad Kumar K Patel  , Vineet C Jain  , Zarana Dedania  , Naimuddin Riyazuddin Saiyed  , Rajendra C Patel
Published: February 2023

A simple, specific, accurate and precise spectrophotometric method was developed and validated for simultaneous estimation of Azelnidipine and Valsartan in Synthetic Mixture. The wavelength of estimation for Azelnidipine was 240.00 nm and for Valsartan was 250.00 nm. Beer’s law is obeyed in the concentration range of 2-10μg/ml and 16-80μg/ml and correlation coefficient of 0.9999 and 0.9993 for Azelnidipine and Valsartan respectively. The % recovery for Azelnidipine and Valsartan were found to be 101.2 % - 101.9 % and 101.8 - 101.9 % respectively. Intraday precision of Azelnidipine and Valsartan were found to be 0.06 – 0.24 and 0.08 – 0.27 % RSD and Interday precision were found to be 0.14 – 0.33 and 0.11 – 0.37 % RSD respectively. The proposed method was also evaluated by the Assay of Synthetic mixture containing Azelnidipine and Valsartan. The % Assay was found to be 100.50 ± 0.002 for Azelnidipine and 100.87 ± 0.001 for Valsartan. Validation of proposed methods was carried out according to ICH Q2R1Guidelines. The proposed methods were found accurate and reproducible for routine analysis of both the drugs in synthetic mixture.
Students’ Perception on the Use of Digital Storytelling as Media In Teaching English Speaking at Anuban Chumchon Phukradueng School, Thailand
Authors: Asmawati Siti Mazuroh , Asmara Candra Hadi
Published: February 2023

This study aimed to investigate the students’ perception on the use of digital storytelling as a media in learning to speak English at 3rd grade students at Anuban Chumchon Phukradueng School, one of the junior high schools in Loei, Thailand. The method used in this study is a qualitative method. A descriptive qualitative design was employed as a research design in this study. The subject of this study was 35 students. The instrument used in this study was adapted questionnaire and interview from the other researcher. According to the findings of this study, using digital storytelling can help students developed their speaking abilities. It could be seen from the result of questionnaire, most of students find digital storytelling help them in improving their speaking skills. Furthermore, students gave positive responses during interviews. Digital storytelling is an engaging and enjoyable method for students studying English. Because as a media, digital storytelling provide video that contain combination of pictures, animation, text and sound to convey story to the audience. The students find it easy to understand the lesson by using digital storytelling.
Alles nur Fake?
Authors: Barth Daniel
Published: February 2023

An einem Fallbeispiel wird aufgezeigt, wie ein pädagogisches Team zunächst die sozialen Voraussetzungen herstellt, um später gemeinsam eine Aufgabe zu bearbeiten. In dieser ersten Phase können zwei gruppale Stimmungsund Affektkonstellationen beobachtet werden, die mit Bion (2001) als »Grundannahme Kampf/Flucht« und »Grundannahme der Abhängigkeit« interpretiert werden. Was als unproduktive »Pseudokooperation« (Fend, 2008, S. 228) erscheint, verändert die Gruppenstruktur. Sobald auf dieser Ebene eine »synkretische«, d.h. nicht-differenzierte Zugehörigkeit entstanden ist, gelingt dem pädagogischen Team eine Aufgabenorientierung, was nach Bion (2001) zentrales Merkmal einer »Arbeitsgruppe« ist.
Warum flatterst Du so mit den Händen?
Authors: Németh Natascha , Stiller Anja
Published: February 2023

Personen des Autismus-Spektrums nehmen die Welt sehr intensiv und damit in einer besonderen Form wahr. Diese Wahrnehmungsschärfe führt regelmäßig zu einer Überforderung des Systems. Durch eine neuronale Reizempfindlichkeit resultiert bei autistischen Menschen eine erhöhte Stressvulnerabilität. Das entsprechende Stresserleben wird durch die unmittelbaren Lebensbedingungen und die damit verbundenen Anpassungsleistungen potenziert. Die entstehenden inneren und äußeren Überforderungen werden dabei durch sogenannte repetitive Verhaltensweisen/Stimming, die sich in verschiedenen Formen ausdrücken können und unwillkürlich sowie bewusst geschehen, reguliert. Stimming kann dazu dienen überwältigende Emotionen einzudämmen und ein beruhigendes Feedback zu erzeugen. Ebenso kann Stimming eine Bewältigungsstrategie sein, die aus der Umwelt resultierenden Sinnesstimulationen zu kanalisieren. Allerdings führen diese Verhaltensweisen mitunter auch zu Stigmatisierungen aus der Umgebungswelt der autistischen Person, wenn diese Verhaltensweisen als nicht adäquat betrachtet werden. Dieser Artikel möchte diesem entgegenwirken und deutlich machen, dass Stimming eine bedeutende Rolle im Leben autistischer Menschen spielt. Das Umfeld des Menschen im Autismus-Spektrum trägt entscheidend dazu bei, das Stresserleben der autistischen Person zu reduzieren. Dafür scheint das Wissen um die Ursachen und Funktionen von Stimming und eine differenzierte sowie individuelle Sichtweise unerlässlich. Ziel sollte es nicht sein, diese repetitiven, notwendigen Verhaltensweisen abzubauen oder den Autismus behandeln zu wollen, sondern den autistischen Menschen dabei zu unterstützen mit dieser Welt leben zu können.
»Taler, Taler, du musst wandern«
Authors: Stritzke Nadyne
Published: February 2023

Der Beitrag illustriert anhand eines Fallbeispiels einer Teamsupervision im Bereich Soziale Arbeit, inwiefern bewusst getroffene Entscheidungen durch unbewusste intrapsychische sowie interpersonelle Dynamiken beeinflusst werden. Dabei stellt sich die supervisorische Frage, wann beziehungsweise wie das Spannungsfeld zwischen bewusst getroffenen Entscheidungen und unbewusster Abwehr der Umsetzung von Entscheidungen Gegenstand der Supervision werden sollte und wie es bearbeitet werden kann.
Aus dem Hier und Jetzt gefallen
Authors: Faber Claus , Hasawenth Thorsten
Published: February 2023

Wir begegnen immer wieder Phänomenen, die uns oder unsere Klientinnen und Klienten »blockieren« oder in einer anderen Form »aus dem Hier und jetzt werfen«. In der offenen Jugendarbeit erleben wir dies auf drei Ebenen: Im Klientinnenkontakt, in Teams und in Organisationen. Dieser Artikel skizziert Übertragung als Erklärungsansatz. Wir können mit dem »triangle of insight« im Hier und Jetzt über unsere Beziehungsfähigkeit handlungsfähig werden. Gerade in der Jugendarbeit sind Übertragungsphänomene besonders stark, und ohne gelingende Beziehungsarbeit ist kein professionelles Handeln möglich. Nutzbar ist der Ansatz aber weit darüber hinaus.
Entscheidungen entscheiden
Authors: Bayas-Linke Dirk , Faulstich Jörg
Published: February 2023

Der Beitrag fokussiert sich auf das Thema Beratung beziehungsweise Supervision in hybriden Organisationen. Die Autoren gehen der Frage nach, welche Modelle und Theorien für die wirksame Arbeit in der Organisation hilfreich sein können, um sich das, was in der Praxis beobachtbar ist, zu erklären. Diese Einschätzungen ergänzen sie mit einem kleinen Ausschnitt aus der von ihnen erlebten Praxis. Was passiert, wenn sich ein Teil der klassischen Organisation – hier ein Softwarebereich in einem großen Konzern – in eine sogenannte Kreisorganisation begibt? Welche Kernprobleme zeigen sich dabei – auf der Organisations-, der Teamund Personenebene? Welche Spannungsfelder werden eröffnet? Welche Erwartungen treffen aufeinander? Und welche – neuen – Erwartungen werden an Führungskräfte und Führungsrollen herangetragen? Ebenso beschreiben die Autoren, wie sich Entscheidungsprozesse, -routinen und -orte im Rahmen des Veränderungsprozesses zum Teil neu konfigurieren.
Dosierte Exposition in der tiefenpsychologisch orientierten Behandlung älterer Menschen
Authors: Reddemann Luise
Published: February 2023

Dargestellt wird die psychodynamisch orientierte Behandlung einer damals 75-jährigen Patientin, die nach vielfältigen Therapien den Wunsch hatte, sich mit den Folgen von Kriegs-und Nachkriegszeit sowie mit den Erfahrungen »schwarzer Pädagogik« auseinanderzusetzen. Das Beispiel zeigt, dass die Arbeit mit einer Patientin – die präzise bestimmte, wie viel sie bearbeiten möchte und sich wohlwollend dabei begleitet fühlte – als hilfreich erlebt wurde und der alten Frau mehr Lebensfreude ermöglichen konnte.
Partisipasi Orang Tua Milenial dalam Aspek Perkembangan Sosial Anak Usia Dini
Authors: Darojah Rani , Sugiharti Sri , Wijayanti Urip Tri
Published: February 2023

Generasi Milenial untuk konteks perspektif perkembangan sosial anak usia dini adalah mereka dengan karakteristik tersendiri  yaitu orang tua (ibu atau ayah) lahir pada tahun 1980 hingga 2000 an mempunyai anak balita dan anak yang akan memasuki usia sekolah.   Tujuan penelitian mendapatkan informasi tentang peran orang tua milenial dalam pengasuhan aspek perkembangan sosial  anak  usia dini di Provinsi Jawa Tengah. Pendekatan yang digunakan deskriptif kuantitatif yang mendeskripsikan, menganalisis, dan menjelaskan orang tua millennial dalam aspek perkembangan sosial anak usia dini. Data yang dipakai  berasal dari Survey Kinerja Akuntabilitas  Program BKKBN tahun 2019.  Novelty  penelitian pengasuhan orang tua Milenial dalam perkembangan sosial anak dengan cara disekolahkan dalam paud/play group/day care  sebesar 62.6 persen , anak  diajak bersosialisasi sebesar 74.7 persen sedangkan  bermain dengan teman sebaya sebesar 91.6 Persen.  Aspek perkembangan sosial lainnya  untuk anak dikursuskan 10.9 persen dan anak diikutkan lomba sebesar 20 persen
Information on Cash Flow Statements and Stock Return
Authors: Sitorus Sri Oktavia Br , Njotoprajitno Rosemarie Sutjiati , Hadianto Bram
Published: February 2023

This research aims to test and analyze information from the cash flow statement on the share return. The cash flow intended is from operating, financing, and investing activities. Meanwhile, the shares utilized belong to the infrastructure, utility, and telecommunication companies listed on the Indonesian capital market between 2018 and 2021. Because this study uses the change in three cash flows, the secondary data from 2017 to 2021 based on the firm annual reports and the stock price at the end of these years are employed. Additionally, the t-statistics and their probability provided by a multiple regression model to statistically examine the hypotheses proposed are applied. Finally, this study concludes that the higher the cash flow from investing activities, the higher the stock return. However, the positive change in the financing cash flow tends to reduce this return. Meanwhile, this return is not affected by the cash flow from operating activities.
Repetitive behaviours in autistic and non-autistic adults: Associations with sensory sensitivity and impact on self-efficacy
Authors: Nwaordu Gabrielle , Charlton Rebecca Ann
Published: February 2023

Restricted and repetitive behaviours are a core feature of autism diagnoses but have not been widely studied in adulthood. This study examined the rates of and associations between repetitive behaviours and sensory sensitivity in autistic and non-autistic adults; and whether repetitive behaviours described as “stimming” impacted coping with difficulties (self-efficacy). Diagnosed autistic (n=182), undiagnosed autistic (n=163) and non-autistic (n=146) adults completed online measures of repetitive behaviours, sensory sensitivity, and self-efficacy for when able and not able to stim. Autistic groups reported higher ratings of repetitive behaviours and sensory sensitivity compared to the non-autistic group. Repetitive behaviours and sensory sensitivity correlated significantly in all groups. There were no differences between the groups on self-efficacy ratings when people were able to stim. However when unable to stim, autistic people reported lower self-efficacy than non-autistic people. Results suggest that repetitive behaviours remain common among autistic adults and are significantly associate with sensory sensitivities. Rather than repetitive behaviours being viewed as negative, stimming was associated with increased self-efficacy. Results suggest that stimming may have beneficial effects. Further work is needed to better understand how repetitive behaviours and stimming manifest in adulthood, how they change over time and their effects for autistic adults.
Perceptual Similarity Mostly Ignores Within-Category Feature Distributions: Evidence From Computational Modeling of Human Categorizations
Authors: Seitz Florian Ismael , Jarecki Jana Bianca , Rieskamp Jörg
Published: February 2023

Categorizing objects is a fundamental human skill, which entails assigning objects to categories based on features. Within categories, the objects are distributed, meaning that in each category the object features may vary and correlate, and processing this distribution can improve categorizations. Whether people use the within-category feature distribution information to categorize objects is unclear due to mixed evidence. To investigate the role of within-category feature distributions in categorization, we designed two experiments, manipulating the variances and correlations of features within categories through simulation-based optimal experimental design. Using computational cognitive modeling in an exemplar-similarity framework, we compared a psychological process that ignores the within-category feature distributions (Euclidean similarity) to a process that considers the within-category feature distributions (Mahalanobis similarity). The experiments (both Ns = 43) clearly showed that most participants did not consider the within-category feature distributions, and their behavior is best described by the simpler Euclidean similarity. Nevertheless, a minority of participants were described by the Mahalanobis similarity, which considers the within-category feature distributions, even though their categorizations were less evident than those of the participants described by the Euclidean similarity. In sum, the results suggest that in categorization the psychological processing of similarities between objects is mostly invariant to the distribution from which the objects stem, which may be because itis computationally more costly to estimate the distribution of features in categories.
Comparing the Ideological Correlates of Anti-Government and Anti-Roma Conspiracy Beliefs in Romania
Authors: Nera Kenzo , Procop Iustina , Klein Olivier
Published: February 2023

Conspiracy theories are often viewed as the manifestation of a “conspiracy mentality” grounded in power-challenging attitudes. Contrary to this approach, it has been proposed that conspiracy theories targeting relatively powerful groups (i.e., upward conspiracy theories) may be ideologically distinct from conspiracy theories targeting relatively powerless groups (i.e., downward conspiracy theories). We tested this contention in the Romanian context (n = 723, preregistered), and compared the ideological and socioeconomic correlates of anti-government (i.e., a relatively powerful group) and anti-Roma (i.e., a relatively powerless group) conspiracy beliefs. Using Principal Components Analysis, we showed that both categories of conspiracy beliefs are statistically distinct. Right Wing Authoritarianism was significantly more related to anti-Roma conspiracy beliefs than to anti-government conspiracy beliefs. However, against our expectations, both types of conspiracy beliefs did not relate differently to subjective socioeconomic status. Overall, the ideological discrepancies between upward and downward conspiracy beliefs were less marked in the Romanian context. Finally, conspiracy mentality was more related to anti-government conspiracy beliefs than anti-Roma conspiracy beliefs. This corroborates the notion that generic measurements of conspiracist ideation may be mostly a measurement of upward conspiracy beliefs, and emphasises the relevance of distinguishing conspiracy theories based on the types of groups they target.
Casting Blackface in Canada: Unmasking the History of ‘White and Black’ Minstrel Shows
Authors: Thompson Cheryl
Published: February 2023

Blackface minstrelsy was the dominant form of mass entertainment for over a century, from the 1840s through the 1940s. In Canada, there has been little scholarly research into the topic but for the work of Stephen Johnson and, in recent years, the works I have published on the subject. One of the reasons blackface has been understudied is the dearth of attention paid to histories of slavery. By exploring the history of casting blackface productions, both ‘white’ minstrelsy (white performers blackening up to imitate the song and dance of African-Americans) and ‘Black’ minstrelsy (Black performers in and out of blackface performing caricatures of themselves in front of majority-white audiences), we gain an understanding of how these shows were produced, and what audiences found appealing about them. Canada has produced its own blackface stars, like Colin ‘Cool’ Burgess (1840–1905) and Calixa Lavallée (1842–1891), both of whom toured the United States and Canada in the late nineteenth century and who not only performed in blackface but also produced songs, some of which are still known today, like “O Canada,” the Canadian national anthem, composed by Lavallée in 1880. Additionally, what the history of casting blackface in Canada shows is a long-standing desire among white audiences for depictions of the American Plantation South that often included the participation of local actors like playwright and writer Charles Wesley Handscomb (1867–1906), who moved to Winnipeg in 1879, who were often cast in touring minstrel productions to sing in blackface.