bluuebunny/crossref_metadata_2025 huggingface dataset:
Hemşirelik İş Rotasyonu Stres Düzeyinin İşe Angaje Olma Üzerine Etkisi: Medeni Durumun Düzenleyici Rolü (The Effect of Nursing Job Rotation Stress Level On Work Engagement: The Moderator Role of Marital Status)
Authors: Kızılkaya Selman
Published: October 2023

Amaç –Bu çalışma, hemşirelik iş rotasyonu stres düzeyinin işe angaje olma üzerine etkisinde medeni durumun düzenleyici rolünü belirlemek amacıyla gerçekleştirildi.Yöntem –Bu araştırma, nicel araştırma yöntemlerinden ilişkisel tarama modeli ile gerçekleştirildi. Araştırmaya Şanlıurfa ilinde görev yapan toplam 555 hemşire katılım sağladı. Çalışmada, anket yöntemi kullanıldı. Anket içerisinde, hemşirelerin kişisel özelliklerinin yanı sıra Hemşirelik İş Rotasyonu Stres Ölçeği (HİRSÖ) ve İşe Angaje Olma Ölçeği (İAOÖ) yer almaktadır.Bulgular –Araştırma sonucunda, hemşirelik iş rotasyonu stres düzeyinin işe angaje olma üzerine etkisinde medeni durumun düzenleyici rolünin olduğu tespit edildi. Evli hemşirelerde iş rotasyonu stres düzeyinin işe angaje olma üzerine etkisinin bekar hemşirelere göre daha belirgin olduğu sonucuna ulaşıldı.Tartışma –Hastaların iyileşme sürecinin her aşamasında yer alan hemşireler çeşitli nedenlerden dolayı strese maruz kalmaktadır. Kötü planlanmış iş rotasyonu hemşirelerin stres yaşamasına neden olan faktörlerden biridir. Hemşirelerin iş rotasyonu stres düzeyinin yüksek olması, işe bağlılığı azalttığı gibi işe angaje olmayı da olumsuz etkilemektedir. Bu durum hemşirelerin evli ya da bekar olmalarına göre farklılık göstermektedir. Evli hemşirelerde iş rotasyonunun stres düzeyi arttıkça işe angaje olma daha belirgin olarak azalmaktadır. Buradan hareketle iş rotasyonlarının bir plan dahilinde ve hemşirelerin özel durumlarına (medeni durum ve çocuk sahibi olma gibi) göre hazırlanması önerilmektedir.
Otel ve Restoran İşletmeleriMutfak Yöneticilerinin TicariMutfak Planlama İlkeleriKonusunda BilgiDüzeylerinin Tespit Edilmesine Yönelik Bir Çalışma (An Exploratory Study on Determining The Knowledge Levels of Kitchen Managers in Hotel and Restaurant Businesses Regarding Commercial Kitchen Planning Principles)
Authors: Bayram Fuat , Nazik Mahmut Hamil
Published: October 2023

Amaç -Bu araştırmanın amacı, otel ve restoran işletmelerinde yiyecek içecek üretiminin gerçekleştirildiği mutfakların planlama aşamasında uzman ekip içinde yer almasıgereken mutfak yöneticilerinin, ticari mutfak planlamaya yönelik bilgi düzeylerini tespit etmektir.Yöntem -Araştırmanının evrenini; Ankara, Antalya ve İstanbul illerinde bulunan oteller ile 1. Sınıf lokanta mutfaklarındagörev yapan 11592 mutfak yöneticisi oluşturmaktadır. Araştırmanın örneklem çapıYamane’nin sosyal bilimler için örneklem çapıbelirleme formülükullanılarak 372 bulunmuştur. Örneklem grubu amaçlıörnekleme tekniklerinden yararlanılarak seçilmiş, mutfak yöneticisinin ticari mutfak planlama bilgi düzeylerinin tespitine yönelik 425 mutfak yöneticisine anket uygulamasıyapılmıştır. Nicel araştırma yöntemlerinden keşfe dayalıilişkisel tarama modeli kullanılarak yürütülmüşbu çalışmada elde edilen verilerin analizi istatistik paket programıkullanılarak yapılmışve çalışmadan elde edilen verilerin analizinde; t testi, Mann-Whitney U testi, ANOVA, Tukey çoklu karşılaştırma testi ve Kruskal Wallis H testi ile Bonferroni düzeltmeli Mann-Whitney U-testi gibi istatistiksel testler kullanılmıştır. Tüm istatistiksel analizlerde önemlilik seviyesi olarak p<0.05 değeri kabul edilmiştir. Bulgular -Elde edilen bulgulara göre yaşilerledikçe mutfak yöneticilerinin ticari mutfak planlamaya yönelik genel bilgi puanlarının anlamlıolarak azaldığı, ticari mutfak planlama yapma sayısıarttıkça mutfak yöneticilerinin genel bilgi puanlarının anlamlıolarak arttığıtespit edilmiştir.Tartışma -Mutfak yöneticilerinin eğitim durumlarına paralel olarak ticari mutfak planlamaya yönelik bilgi puanlarının yükselmesi çalışmanın diğer bir sonucu olarak göze çarpmakta olup bu da alana yönelik verilen eğitimlerin önemini ortaya koymaktadır.
Turizm Krizleri Sonrası Yeniden Şekillenen Konaklama İşletmeciliği ve İkinci Konut Turizminin Geleceği (The Future of Reshaped Accommodation Management and Second Home Tourism After Tourism Crises)
Authors: Güçlü Caner
Published: October 2023

Amaç –Bu araştırmanın amacı, Alanya'da ikinci konut turizminin artan önemini incelemek ve bu turizmin yerel halk üzerindeki etkilerini anlamak, özellikle Covid-19 sonrası dönemdeki gelişmeleri vurgulamaktır. Aynı zamanda, yerel halkın ikinci konut sahiplerine yönelik tutumlarını, algılarını ve karşılıklı ilişkileri değerlendirmek, ikinci konut turizminin Alanya'nın ekonomik yapısı üzerindeki etkilerini analiz etmek, yerel halkın endişelerini ve beklentilerini belirlemek, ikinci konut turizminin kentsel planlama, çevre sürdürülebilirliği ve altyapı üzerindeki etkilerini incelemektir. Bu çalışma, Alanya'da ikinci konutturizmi ile ilgili daha derinlemesine bir anlayış geliştirme ve gelecekteki kentsel gelişim ve turizm politikalarına katkıda bulunma amacını taşımaktadır.Yöntem –Araştırmanın verileri, ikincil veri analizi yöntemi kullanılarak, doküman incelemesi yoluyla elde edilmiştir. Araştırmanın verileri Alanya'daki ikinci konut turizmi ile ilgili yerel halkın görüşlerini incelemeyi amaçlayan 147 yorumdan elde edilmiştir. Bu yorumlar, www.yenialanya.com ve www.gazetealanya.com gibi yerel haber sitelerinde yayınlanan haberlerin altındaki yorumlardan seçilmiştir. Bu şekilde, Covid-19 sonrası ikinci konut turizmi hakkındaki yerel halkın düşüncelerini analiz etmek için elde edilen veriler içerik analizi yöntemi kullanılarak ana tema ve alt temalar oluşturulmuştur. Bulgular –Bulgular, altı ana tema etrafında toplanmıştır. Yabancıların konut kiralaması ve emlak satın alması, Alanya'da kültürel etkileşimi artırmıştır, ancak yerel halk için konut kiralarındaki artış ve mülkiyet erişimini zorlaştırmıştır. İkinci konut turizmi, emlak fiyatlarını artırmış, işsizliği etkilemiş ve yerel iş dünyasına yabancı rekabetini getirmiştir. Ayrıca, çevre sorunları ve yerel halkın endişelerini de artırmıştır.Tartışma –Araştırmanın bulguları, Alanya'da ikinci konut turizminin yerel ekonomi, emlak piyasası, iş gücü ve çevresel dinamikler üzerinde önemli etkilere sahip olduğunu göstermektedir. Yabancıların artan konut talebi, yerel konut kiralarını artırmış ve bu durum ekonomik zorluklarla mücadele eden yerel halk için önemli bir sorun haline gelmiştir. Emlak fiyatlarının yükselmesi, mülkiyet erişimini kısıtlamış ve yerel halkın ekonomik refahını etkilemiştir. İşsizlik ve iş kayıpları, özellikle emlak sektöründe,yerel iş gücünün karşılaştığı zorlukları vurgulamaktadır. Ayrıca, çevresel sorunlar ve yerel halkın endişeleri, ikinci konut turizminin sürdürülebilirlik ve toplumsal uyum açısından da ele alınması gerektiğini ortaya koymaktadır. Bu bulgular, Alanya'daki ikinci konut turizmi yönetimi ve politika oluşturulabilmesi için bilgi sağlamakta ve gelecekteki araştırmalar için temel oluşturmaktadır.
Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the Nlgn3R451C Mouse Model of Autism
Authors: Hosie Suzanne , Abo-Shaban Tanya , Mou Kevin , Balasuriya Gayathri Kumar , Mohsenipour Mitra , Alamoudi Mohammed Uthman , Filippone Rhiannon Talia , Franks Ashley Edwin , Bornstein Joel Charles , Nurgali Kulmira , Hill-Yardin Elisa L
Published: October 2023

Individuals with autism often experience gastrointestinal issues but the cause is unknown. Many gene mutations that modify neuronal synapse function are associated with autism and therefore may impact the enteric nervous system that regulates gastrointestinal function. A missense mutation in the Nlgn3 gene encoding the cell adhesion protein, Neuroligin-3, was identified in two brothers with autism who both experienced severe gastrointestinal dysfunction. Mice expressing this mutation (Nlgn3R451C mice) are a well-studied preclinical model of autism and show autism-relevant characteristics, including impaired social interaction and communication, as well as repetitive behaviour. We previously showed colonic dysmotility in response to GABAergic inhibition and increased myenteric neuronal numbers in the small intestine in Nlgn3R451C mice bred on a mixed genetic background. Here we show that gut dysfunction is a persistent phenotype of the Nlgn3 R451C mutation in mice backcrossed onto a C57BL/6 background. We report that Nlgn3R451C mice show faster gastrointestinal transit in vivo and have longer small intestines compared to wild-types due to a reduction in smooth muscle tone. In Nlgn3R451C mice, we observed a decrease in resting jejunal diameter and neurally-regulated dysmotility as well as shorter durations of contractile complexes in the ileum. In Nlgn3R451C mouse colons, short contractions were inhibited to a greater extent by the GABAA antagonist, gabazine, compared to wild-type mice. Inhibition of nitric oxide synthesis decreased the frequency of contractile complexes in the jejunum, but not the ileum, in both wild-type and Nlgn3R451C mice. These findings demonstrate that changes in enteric nervous system function contribute to gastrointestinal dysmotility in mice expressing the autism-associated R451C missense mutation in the Neuroligin-3 protein.
Isolation and Molecular Characterization of a Novel Podo-virus BIS08P22 having a Unique Terminase Enzyme Representing a new Genus in Class Caudoviricetes
Authors: Sattar Sadia , Carbone Vincenzo , Basharat Zarrin , Bostan Nazish , Tariq Aamira , Javed Sundus , Ullah Inam , Khanum Sofia , Yaqoob Akasha , Ahmed Ibrar , Abbas Muhammad Athar , Shah Syed Tahir Abbas , Altermann Eric
Published: October 2023

Salmonella enterica includes enteric pathogens of zoonotic potential, possessing one of the largest pools of temperate phages in their genomes. One such class of phages previously called Podoviridae (Now genera placed directly under class Caudoviricetes temporarily) is the largest group of temperate phages that lysogenize clinically and economically important Salmonella enterica serovars. These phages are capable of generalized transduction and are well known for carrying foreign DNA (mobile genetic elements and resistance genes) to new bacterial species that play a major role in the evolution, pathogenicity, and host adaptability of Salmonella serovars. Here we report a novel species of podo viruses; Salmonella phage BIS08P22 (BIS08) that infects Salmonella enterica serovar Typhimurium strain SE-BS17 (Acc. NO: MZ503545). Phage BIS08 was viable only at biological pH and temperature (pH7 and 37 °C) and features 41,574 -base pair (bp) linear ds DNA genome with 47% GC content. It encodes 73 putative Open Reading Frames (ORFs), has a mosaic arrangement, and shares only 16 core genes with its closest homologs. BIS08 genome possesses only 52 % homology (genome-wide Nucleotide homology by VIRIDIC analysis) with members of the genus Lederbergvirus which is not sufficient to place it in the same genus. This phage has a unique terminase enzyme (DNA packaging motor) with no nucleotide and protein homology with any known member of the Lederbergvirus genus. We carried out a detailed phylogenetic and genome analysis of this novel phage and proposed its placement in a new genus. Our study also suggests a revision in the classification of the genus Lederbergvirus. We also performed in silico structural analysis of the BIS08 unique terminase enzyme comparing it to its close homologs.
Artificial Intelligent Image Recognition System for Preventing Wrong Side Upper Limb Surgery
Authors: Wu Yi-Chao , Chang Chao-Yun , Huang Yu-Tse , Chen Sung-Yuan , Chen Cheng-Hsuan , Kao Hsuan-Kai
Published: October 2023

Our image recognition system mainly judges whether the left upper limb in the image is the left upper limb or the right upper limb through our deep learning model in the image. The doctor then could give the correct surgical position. From the experimental results, it could be found that the precision rate and recall rate of the intelligent image recognition system proposed in this paper for preventing the upper limb dislocation surgery could reach 98% and 93%, respectively. It proved that our artificial intelligent image recognition system, AIIRS, could indeed assist orthopedic surgeons to prevent the occurrence of left and right dislocation in upper limb surgery. At the same time, this paper also completes the IRB application approval through the prototype experimental results and will conduct the second phase of human trials in the future. It showed that the research results of this paper will be of great benefit and research value to upper limb orthopedic surgery.
Analysis and Optimal Control Measures of a Typhoid Fever Mathematical Model for a Multiple Socio-Economic Population
Authors: Ekwueme Stephen Ekwueme , Collins Obiora Cornelius , Onah Ifeanyi Sunday
Published: October 2023

Typhoid fever is an infectious disease that affects humanity worldwide particularly in the lower socio-economic communities where many individuals are exposed to a dirty environment and unclean food. A mathematical model is formulated to analyze the impact of control measures such as vaccination of susceptible humans, treatment of infected humans and sanitation in the different socio-economic communities. The model assumed that the population comprises of two socio-economic classes. The essential dynamical system analysis of our model was appropriately carried out. The impact of the control measures was analyzed, and the optimal control theory was applied on the control model to explore the impact of the different control measures. Numerical simulation of the models and the optimal controls were carried out and results obtained indicates that the overall combination of the control measures eradicates Typhoid fever in the population but the controls are more optimal in the higher socio-economic communities.
Omega-3 Lipid Mediators: Modulation of the M1/M2 Macrophage Phenotype and its Protective Role in Chronic Liver Diseases
Authors: Videla Luis A , Valenzuela Rodrigo , Del Campo Andrea , Zuñiga-Hernandez Jessica
Published: October 2023

The complex interplay between dietary factors, inflammation, and macrophage polarization is pivotal in the pathogenesis and progression of chronic liver diseases (CLDs). Omega-3 fatty acids (FAs) have been attracted attention due to their potential to modulate inflammation and exert protective effects in various pathological conditions. This review explores the emerging role of omega-3 FAs and their specialized pro-resolving mediators (SPMs) in the context of macrophage polarization, with a focus on chronic liver diseases. Omega-3, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have promising effects in mitigating inflammation and enhancing the resolution of inflammatory responses. They influence the M1/M2 macrophage phenotype balance, promoting a shift towards the M2 anti-inflammatory phenotype. SPMs, such as resolvins (Rvs), protectins (PDs), and maresins (MaRs), have emerged as potent regulators of inflammation and macrophage polarization. They show anti-inflammatory and pro-resolving properties. These mediators modulate the expression of cytokines, facilitate the phagocytosis of apoptotic cells, and promote tissue repair. MaR1, in particular, has demonstrated significant hepatoprotective effects by promoting M2 macrophage polarization, reducing oxidative stress, and inhibiting key inflammatory pathways such as NF-κB. In the context of CLD, such as nonalcoholic fatty liver disease (NAFLD) and cirrhosis, omega-3 and their SPMs have shown promise in attenuating liver injury, promoting tissue regeneration, and modulating macrophage phenotypes. However, the mechanisms underlying their effects and their interactions with other cell types within the liver microenvironment require further investigation. Understanding the intricate relationship among SPM and macrophage polarization holds unlimited potential for the development of novel therapeutic strategies for chronic liver diseases.
Comparative Physiological and Transcriptome Analysis of Crossostephium chinense Reveals Its Molecular Mechanisms of Salt Tolerance
Authors: Wang Yuxin , Liu Miao , Guo Ziyu , Liang Yilin , Lu Yufan , Xu Yuxian , Sun Ming
Published: October 2023

Crossostephium chinense is a wild species with strong salt tolerance, which has great potential to improve the salt tolerance of cultivated chrysanthemums. Conversely, the unique salt-tolerant molecular mechanisms of Cr. chinense are still unclear. This study performed a comparative physiological and transcriptome analysis of Cr. chinense, Chrysanthemum lavandulifolium and their hybrids. The physiological results showed that Cr. chinense maintained a higher superoxide dismutase (SOD) activity, to alleviate the oxidative damage to membrane. KEGG enrichment analysis showed that the plant hormone signaling transduction and the MAPK signaling pathway were mostly enriched in Cr. chinense and hybrids under salt stress. Further weighted gene co-expression network analysis (WGCNA) of DEGs suggested that the abscisic acid (ABA) signaling transduction may play a significant role in the salt-tolerant mechanisms of Cr. chinense and hybrids. The tissue-specific expression patterns of the candidate genes related to ABA signaling transduction and MAPK signaling pathway indicated that genes related to ABA signaling transduction performed significant expression levels under salt stress. This study provides a theoretical foundation for future research into the molecular mechanism of salt tolerance in chrysanthemums under salt stress.
Comparison of Failure Loads of Polycrystalline Ceramics with Different Amount of Yttria, Glass-Ceramic, Polymers in Two Different Test Setups
Authors: Alghazzawi Tariq F. F
Published: October 2023

The objective was to compare the failure loads of glass ceramic, and polymer crowns against yttria-partially stabilized zirconia (Y-PSZ) crowns with varying yttria concentrations. Monolithic crowns of zirconia (Cercon XT, Katana UTML, BruxZir Anterior), glass ceramic (Celtra press, IPS e.max press, Lisi press), and polymeric materials (Trilor, Juvora, Pekkton) were fabricated and cemented to epoxy abutments. The total number of specimens was 135 for crowns and 135 for discs (15 specimens per material type and design). A universal testing machine was used to perform compressive loading of all crowns to failure with a steel hemisphere along the longitudinal axis of the abutments. Energy dispersive spectroscopy (EDS) was used to identify the concentration (mol% yttria-partially stabilized zirconia) for each zirconia brand. The data were analyzed using a generalized linear model and regression analysis. The results revealed significant differences (P < .05) in mean failure loads for different crown materials: Trilor (6811 ± 960 N) > Juvora (5215 ± 151 N) > Cercon (4260 ± 520 N) = BruxZir (4186 ± 269 N) = e.max (3981 ± 384 N) > Katana (3195 ± 350 N) = Lisi (3173 ± 234 N) = Pekkton (3105 ± 398 N) > Celtra (2696 ± 393 N). EDS showed that the zirconia materials contained yttria at different concentrations (BruxZir = 5Y-PSZ, Cercon = 4Y-PSZ, Katana = 3Y-PSZ). The yttria concentration had a significant effect on the failure load of the Katana (3Y-PSZ) crowns, which revealed lower failure loads than the Cercon (4Y-PSZ) and BruxZir (5Y-PSZ) crowns. New zirconia materials are provided with different yttria concentrations (3Y-, 4Y-, and 5Y-PSZ). Since a higher yttria concentration increases the translucency, clinicians should be aware that 4-5 wt% yttria-partially stabilized zirconia materials provide comparable or higher mechanical properties than e. max glass ceramic for dental application of crowns.
Delving into Molecular Pathways: Analyzing the Mechanisms of Action of Monoclonal Antibodies Integrated in IMGT/mAb-DB for Myasthenia Gravis
Authors: Golfinopoulou Rebecca , Giudicelli Véronique , Manso Taciana , Kossida Sofia
Published: October 2023

Background: Myasthenia Gravis (MG) is a rare autoimmune disease presenting with au-to-antibodies that affect the neuromuscular junction. Aside from symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs). IMGT®, the international ImMunoGe-neTics information system® (https://www.imgt.org), extends the characterization of therapeutic antibodies with a systematic description of their mechanisms of action (MOA) and makes them available through its database for mAbs and fusion proteins, IMGT/mAb-DB.
Methods: Using the available literature data combined with the amino acid sequence analyses from mAbs managed in IMGT/2Dstructure-DB, the IMGT® protein database, biocuration allowed to define in a standardized way descriptions of MOA of mAbs that target molecules towards MG treatment.
Results: New therapeutic targets include FcRn and molecules such as CD38, CD40, CD19, MS4A1 and interleukin-6 receptor. A standardized graphical representation of the MOA of selected mAbs was created and integrated within IMGT/mAb-DB. The main mechanisms involved in these mAbs are either blocking or neutralizing. Therapies directed to B cell depletion and plasma cells have a blocking MOA with an immunosuppressant effect along with Fc-effector function (MS4A1, CD38) or FcγRIIb engager effect (CD19). Monoclonal antibodies targeting the complement also have blocking MOA with a complement inhibitor effect and treatments targeting T cells have a blocking MOA with an immunosuppressant effect (CD40) and Fc-effector function (IL6R). On the other hand, FcRn antagonists present a neutralizing MOA with an FcRn inhibitor effect.
Conclusion: The MOA of each new mAb needs to be considered in association with the immuno-pathogenesis of each of the subtypes of MG in order to integrate the new mAbs as a viable and safe option in the therapy decision process. In IMGT/mAb-DB, mAbs for MG are characterized by their sequence, domains, chains and their MOA is described.
Network Pharmacology of Potentilla nepalensis Extract Revealed p53, Nf-kB1, and HSP Proteins As Potential Biomarkers
Authors: Praveen Mallari , Ullah Ihsan , Buendia Ricardo , Ahmad Khan Imran , Sayed Mian Gul , Bhatt Mashooq Ahmad , L. zeidan Noha , Yaseen Muhammad
Published: October 2023

Potentilla nepalensis belongs to the Rosaceae family, and has numerous therapeutic applications as potent plant-based medicine. Forty phytoconstituents (PCs) from the root and stem through n-hexane (NR and NS) and methanolic (MR and MS) extracts were identified in our earlier studies. However, the PCs affecting human genes and their roles in the body are not disclosed till now. In this study, we employed network pharmacology, molecular docking, molecular dynamics simulations (MDS), and MMGBSA methodologies. SMILES format of PCs from the PubChem used as input to DIGEP-Pred, 764 identified as the inducing genes. Their enrichment studies have shown inducing genes gene ontology descriptions, involved pathways, associated diseases, and drugs. PPI networks constructed in String DB and network topological analysing parameters done in Cytoscape v3.10 revealed three biomarkers, TP53 from MS, NR, and NS induced genes; HSPCB and Nf-kB1 from MR induced genes. From 40 PCs, two PCs 1b (MR) and 2a (MS), showed better binding scores (kcal/mol) with p53 protein of -8.6, and -8.0; three PCs 3a, (NR) 4a and 4c (NS) with HSP protein of -9.6, -8.7, and -8.2. MDS and MMGBSA revealed these complexes are stable without higher deviations with better free energy values. Biomarkers identified in this study, have a prominent role in numerous cancers. Thus, further investigations such as in-vivo and in-vitro should be done to find the molecular functions and interlaying mechanism of the identified biomarkers on numerous cancer cell lines in considering the PCs of P.nepalensis.
Disproof of Several Recently Published Results in Ring Theory
Authors: Pandey S K
Published: October 2023

In this note we consolidate and give a brief description of several recently published results in ring theory having disproof. These results have been published during 2016 to 2021 in the so called non-predatory reputed mathematical journals indexed in the well known database like Scopus. We have considered results on rings in which each element is a sum of two idempotents appeared in Canad. Math. Bull. (2016), weakly tripotent rings appeared in Bull. Korean Math. Soc. (2018) and Rendiconti Sem. Mat. Univ. Pol. Torino (2021), invo-regular unital rings appeared in Ann. Univ. Mariae Curie-Sklodowska Sect. A Mathematica (2018) and Locally Invo-Regular Rings appeared in Azerbijan Journal of Mathematics (2021).
EL EJERCICIO DE LA LIBERTAD SINDICAL EN COLOMBIA DESDE LA COMISIÓN DE EXPERTOS EN APLICACIÓN DE CONVENIOS Y RECOMENDACIONES (CEACR) DE LA OIT
Authors:   Corporación Universitaria Republicana, De Lafond De León Francisco Rafael Ostau , Niño Chavarro Ángela
Published: October 2023

This research shows the results of the analysis of the observations of the Committee of Experts on the Application of Conventions and Recommendations (CEACR) of the International Labor Organization (ILO) produced between 2000 and 2021 in relation to the exercise of freedom of association in Colombia in compliance of the Conventions number 87 and 98 of this specialized agency of the UN. This analysis allowed an approximation to the understanding of the degree of responsibility on the part of the Colombian State for the non-guarantee to the exercise of the fundamental principle of union freedom and its effects in the world of work in Colombia.
English Lecturers' Difficulties in Teaching English for Specific Purposes (ESP) in Various Higher Education in Indonesia
Authors: Fitria Tira Nur
Published: October 2023

This research investigates the English lecturers’ difficulties in teaching English for Specific Purposes (ESP) in higher education. This research is descriptive qualitative. There are 58 English lecturers from various higher education involved in this research. The analysis shows that the most dominant English lecturers teach ESP in the 2nd semester. Besides, in the 1st, and 3rd semesters. English skills taught by English lecturers in ESP courses are speaking, writing, reading, speaking, vocabulary, and translation. Speaking skills is the difficult English skill taught by them in the ESP course. The most dominant English lecturers have been teaching ESP for more than 5 years. They state that teaching ESP requires more challenges than teaching EGP (English for General Purposes). In the implementation of teaching ESP, they face several difficulties including) 1) making syllabi and lesson plans. 2) making ESP course materials according to student needs. 3) selecting and using learning methods. 4) getting ESP textbooks related to student needs. 5) making/creating ESP textbooks related to student needs. 6) difference in students' English proficiency levels. 7) difference in the level of student's motivation to learn English. 8) different levels of students' awareness of the importance of ESP. 9) the institution’s policy related to the ESP course curriculum has not been clearly stated. 10) institutional policies related to facility policies are not adequate. 11) the number of lectures/credits, and the number of semesters in the ESP course are not as expected. 12) compensation (income) in teaching ESP courses is not expected.
Effectiveness of Use of Historical Learning Media Based on Mobile Learning in Increase Awareness of History of Students at SMAN 1 Sumberejo
Authors: Meihan Andre Mustofa
Published: October 2023

Education in this era requires technology as a supporting facility in facilitating the learning process. Based on observations made at SMA Negeri 1 Sumberejo, it was found that the history learning media used was simple, and the learning was still teacher-centered. Monotonous subject matter and teaching concepts that only memorize textbooks make students lazy to study. This problem affects students' historical awareness. The historical awareness of students at SMAN 1 Sumberejo is still low, as evidenced by the results of the distribution of students' historical awareness questionnaires in class X IPS of SMAN 1 Sumberejo, which obtained an average score of only 63.05 or around 42.03%. This study aims to determine how effective mobile learning-based history learning media is in increasing students' historical awareness at SMAN 1 Sumberejo. The method used in this research is the experimental research method. Based on the discussion results, it can be concluded that using mobile learning-based historical learning media at SMAN 1 Sumberejo has proven effective in increasing students' historical awareness. This conclusion is based on hypothesis H0 is rejected, and H1 is accepted because the independent sample t-test obtained a sig of 0.000. Or the t value has a significance level (2-tailed) < (0.05).
Implementing the PJBL (Project Based Learning) Method Using Canva Infographics to Improve Student’s Creativity and Multicultural Understanding
Authors: Purnamasari Dyah Emarikhatul
Published: October 2023

The low level of creativity and the understanding of students in the process of learning sociology a problem we are very classical at school. This research has the aims to describe the implementation of the Canva Infographic-based on PjBL (Project Based Learning) method in terms of increasing students' understanding and creativity. This type of research is descriptive qualitative. Data collection techniques used are interviews and documentation. The type of data used is primary and secondary data. The results of this research are that through the Canva Infographic-based PjBL method, students become more active and creative in the learning process because students are a source of learning. Students search for the material to be studied themselves then present and discuss the results of the PjBL that have been done. Students creativity are based on the creativity of students infographics, the originality of the project and the smoothness and flexibility of the presentation and discussion process. The process of learning this project consists of several stages of the student learning process, namely collecting information, doing projects, presenting and discussing. Based on these stages, the PjBL method learning process was successful in increasing students' understanding and creativity.
Assessment of Islamic Bank Soundness: Analysis Using CAMELS, RGEC and ALTMAN Z Score Methods
Authors: Shabri Husni , Hosen Muhamad Nadratuzzaman
Published: October 2023

The purpose of this study is to analyze the soundness level of PT BCA Syariah. This study is descriptive research with a quantitative approach.The paper used data on the annual financial statements of PT BCA Syariah for the period 2017 - 2021. The analysis using CAMELS, RGEC and Altman Z-Score methods. The results show that overall PT BCA Syariah in the 2017-2021 period was at the Health level in the CAMELS, RGEC and Altman Z-Score assessment methods. The highest health and health condition of PT BCA Syariah during the Covid-19 pandemic is a management effort in carrying out appropriate, focused and planned strategies and risk mitigation. The three analytical methods show the same results so that they can be used as a reference for assessing the health of other Islamic banks
Comparative analysis of the mortality structure of the urban and rural population of the rostov region for the period from 2019 to 2022
Authors: Sharkunov N. P. , Shin V. F. , Makarenko A. S. , Moroz A. A. , Memetova A. S. , Kim Yu. E. , Grishin D. V.
Published: October 2023

The purpose of the study: to study the structure of mortality of the population of the Rostov region among residents of the city and village. Materials and methods. Data from statistical collections of the territorial body of the Federal State Statistics Service for the Rostov Region for the period 2019–2022 and data from the unified state register of civil status records for the same period using methods of comparative analysis and statistical processing were used. Results. During the study period, there is a downward trend in the total population of the region, against which there is an increase in mortality in the first three years of the study and a slight decrease in 2022. The peak of mortality growth is in 2021, which, according to the authors of the article, is associated with the COVID-19 pandemic. The prevalence of the urban population over the rural population has been established. Diseases of the circulatory system prevailed as the main cause of mortality among both population groups throughout the study period. Conclusion. Throughout the entire period of the study, there is a clear trend towards a decrease in the total population of the region, against which, during the first three years, there is an annual increase in the total number of deaths, both among city residents and among rural residents, in 2022 there is a decrease in the total number of deaths compared to 2021 among both population groups, while not reaching the 2019 level. The maximum increase in mortality from all causes falls on 2021, and the maximum increase is observed among residents of the city and village, while in the city it is much higher than in rural areas. This fact is certainly related to the impact on the overall mortality of the COVID-19 pandemic. Throughout the study period, mortality from diseases of the circulatory system prevailed over other causes.
Finite-element model of a sole with the using of cellular objects
Authors: Naprasnikov V. V. , Kovaleva I. L. , Polozkov Y. V. , Kunkevich D. P. , Borodulya A. V.
Published: October 2023

One of the possible approaches to the formation of the optimization model of the underlay is the use of cellular objects. At the same time, the question of constructing geometric models of such objects is relevant. Code fragments and construction results for one variant of geometry in IronPython language in SpaceClaim environment to solve such a problem are given. A possible approach to solving the problem of forming boundary conditions changing in time and space is described.
Optimization of the iot network protocol choozing for monitoring audio information
Authors: Vishnyakou U. A. , Shaya Bahaa
Published: October 2023

The subject of research is the choice of a protocol in the Internet of Things (IoT) network for monitoring and analyzing audio information. The purpose of the article is to optimize the process of choosing a protocol for monitoring audio information based on IoT and evaluate the results. The authors have developed an IoT framework for monitoring and analyzing audio and voice information. The IoT network includes a sound sensor (microphone), a unit for analyzing the information received from it and a decision-making module. The description of protocols in the IoT network for assessing the sound level is given: the Wireless USB standard, the narrowband standard of the NB-IoT.

The hierarchy analysis method was used to select the best protocol. The methodology and its main formulas for calculating the best option are given. A table of the four selected protocols for the IB network is given. As characteristics of the protocols, the following are considered: downlink speed, latency, device bandwidth, device transmission power. A matrix of paired comparisons of protocol parameter indicators based on expert assessments has been formed. Four matrices of paired comparisons of transmission standards variants in relation to the indicator of speed, delay, bandwidth of devices, transmission power of devices are constructed. Calculations of local vectors and priority vectors of quality indicators were performed for these four matrices. Then the matrix of vectors of global priorities is calculated by calculating the sum of the products of local vectors of matrices of paired comparisons of transmission standards variants on the corresponding priority vectors of quality indicators of the matrix of paired comparisons of protocol parameters. From the results obtained, the best protocol option for the network and sound monitoring was determined by the maximum value.
Density of dispersal sources affects to what extent restored habitat is used: a case study on a red-listed wood-dependent beetle
Authors: Djupström Line Boberg , Johansson Victor , Lindman Ly , Schroeder Martin , Weslien Jan , Ranius Thomas
Published: October 2023

When restoring habitats, an important question is whether the spatial distribution of habitat affects its contribution to biodiversity conservation. In Sweden, high-cut stumps are routinely created at forestry operations. By counting the number of exit holes of a red-listed beetle, Peltis grossa, we assessed occurrence, colonisations and extinctions per high-cut stump and beetle density per clear-cut. We found a threshold, at which the form of the relationship between density of the beetle and density of high-cut stumps per clear-cut changes abruptly. The beetle density was considerably higher where the density of high-cut stumps exceeded 4.5 per hectare. Such thresholds can be explained by colonisation-extinction processes. Observed colonisation-extinction dynamics were consistent with metapopulation theory. For instance, there was a positive relationship between colonisation rate and a connectivity measure that considered beetle abundance and distance for each high-cut stump in the surrounding area. However, the relationship disappeared when using a connectivity measure solely based on the distance of the high-cut stumps. The observed threshold implies that P. grossa benefits from aggregating the same total number of created high-cut stumps into fewer clear-cuts. This is because the total area with a density of high-cut stumps exceeding the threshold increases, and this expands the number and size of dispersal sources. Therefore, P. grossa and other species that reveal thresholds in their distribution patterns, are favoured when conservation measures are more spatially aggregated than what is resulting from current Swedish policy.
Sexual Dimorphism during Integrative Endocrine and Immune Responses to Ionizing Radiation in Mice
Authors: Burke Marissa , Wong Kelly , Talyansky Yuli , Mhatre Siddhita D. , Mitchell Carol , Juran Cassandra M. , Olson Makaila , Iyer Janani , Puukila Stephanie , Tahimic Candice G.T. , Christenson Lane K. , Lowe Moniece , Rubinstein Linda , Shirazi-Fard Yasaman , Sowa Marianne B. , Alwood Joshua S. , Ronca April E. , Paul Amber M.
Published: October 2023

Exposure to cosmic ionizing radiation is an innate risk of the spaceflight environment that can cause DNA damage and altered cellular function. In astronauts, longitudinal monitoring of physiological systems and interactions between these systems are important to consider for mitigation strategies. In addition, assessments of sex-specific biological responses in the unique environment of spaceflight are vital to support future exploration missions that include both females and males. Here we assessed sex-specific, multi-system immune and endocrine responses to simulated cosmic radiation. For this, 24-week-old, male and female C57Bl/6J mice were exposed to simplified five-ion, space-relevant galactic cosmic ray (GCRsim) radiation at 15 and 50 cGy, to simulate predicted radiation exposures that would be experienced during lunar and Martian missions, respectively. Blood and adrenal tissues were collected at 3- and 14-days post-irradiation for analysis of immune and endocrine biosignatures and pathways. Sexually dimorphic adrenal gland weights and morphology, differential total RNA expression with corresponding gene ontology, and unique immune phenotypes were altered by GCRsim. In brief, this study offers new insights into sexually dimorphic immune and endocrine kinetics following simulated cosmic radiation exposure and highlights the necessity for personalized translational approaches for astronauts during exploration missions.
“I still don’t know if I am doing the right thing”: A qualitative study of experiencing cauda equina syndrome and its aftercare in the UK.
Authors: Srikandara Nisaharan , Clark Simon , Wilby Martin , Marson Tony , Noble Adam
Published: October 2023

STUDY DESIGN
Qualitative, semi structured interviews.
OBJECTIVES
Cauda Equina Syndrome (CES) is a neurological emergency that can cause permanent disability to the lower limbs, including pain, weakness, and bladder, bowel and sexual dysfunction. There is little evidence on the lived experience of patients with different severities of CES. This study sought to address this.
SETTING
The interviews were conducted with persons who had experienced CES and been operated on for this condition in the UK.
METHODS
A sampling frame was used on a pre-existing database to select a maximum variation sample. Interviews were audio recorded and transcribed for thematic analysis supported by NVivo.
RESULTS
Data saturation was achieved with 22 patients (12 female, 10 male) of whom 10 had CES-incomplete and 12 had CES-complete. Average age was 46 years and time since the operation was 62 months. Most interviews took place at the patients’ home or workplace. Data analysis identified 4 main data themes: 1) Varying priorities of physical health; 2) A fragmented healthcare service; 3) The process of adjustment; and 4) Anticipatory anxiety and diminished sense of self-worth.
CONCLUSION
Currently, CES is managed as an acute condition in hospital. The data themes present CES can be a chronic condition, which requires holistic support to address long-term outcomes. This highlights the importance of using the Cauda Equina Syndrome Core Outcome Set (CESCOS) in CES research studies to record these outcomes.
Fungal toxin fusicoccin enhances plant growth by upregulating 14-3-3 interaction with plasma membrane H+-ATPase
Authors: Ohkanda Junko , Kiriyama Hironaru , Kinoshita Satoru , Hayashi Yuki , Kasuga Shigemitsu , Kinoshita Toshinori , Irieda Hiroki
Published: October 2023

Fusicoccin-A (FC-A) is a diterpene glucoside produced by a pathogenic fungus. FC-A is phytotoxic and induces stomatal opening and leaf wilting, eventually leading to plant death. Here, we report that FC-A enhances plant growth by stabilizing the protein-protein interaction between plasma membrane (PM) H+-ATPase and 14-3-3 in guard cells, promoting stomatal opening and thus photosynthesis. Long-term treatment of Arabidopsis plants with FC-A resulted in ~ 30% growth enhancement. Structurally similar fusicoccin-J (FC-J) showed a similar degree of growth-promotion activity as FC-A, whereas the more hydrophilic fusicoccin-H (FC-H) exhibited no effect on plant growth, indicating that the enhancement of plant growth observed with FC-A and FC-J involves upregulation of the protein-protein interaction between PM H+-ATPase and 14-3-3 in guard cells, which promotes stomatal opening and photosynthesis.
Implicitly Activating Mindfulness: Does Trait Self-Control Moderate Its Effect on Aggressive Behaviour?
Authors: Thériault Rémi , Dandeneau Stéphane
Published: October 2023

Objectives.
Previous research shows that a novel experimental paradigm consisting of implicitly activating (“priming”) concepts associated with mindfulness through a scrambled sentence task yields positive social effects on cognition and affect. Yet, its effects on social behaviour warrant further investigation. As several studies link mindfulness to lower aggression, the latter represents a promising candidate to investigate within the current paradigm. Furthermore, research has demonstrated that personality traits—such as trait mindfulness—moderate the effect of the mindfulness prime, highlighting the importance of identifying potential moderators.
Methods.
In a first hypothesis-generating (exploratory, non-preregistered) study, we investigated which of several personality variables most meaningfully related to the priming mindfulness procedure.
Results.
Self-control emerged as the only meaningful moderator. Accordingly, we specifically tested the interaction between self-control and the mindfulness priming procedure in two additional hypothesis-testing (confirmatory, preregistered) studies using larger samples. The results from the first study did not replicate: the critical interaction of interest was not significant in both studies.
Conclusions.
We discuss the implications of these conflicting results and highlight the importance of preregistered replication studies in mindfulness research.
Preregistration.
The last two studies were preregistered on the Open Science Framework (https://osf.io/582wx/?view_only=147b4bcee2de46f8aea34258d5e08122 and https://osf.io/w46r9/?view_only=b71b93ac96814967af034fb1fb6fda7f).
First Swedish case of fatal equine parasitic encephalitis by Halicephalobus gingivalis
Authors: Olofsson-Sannö Karin Maria , de Velde Norbert van , Peletto Simone , Iulini Barbara , Pratley Laura , Modabberzadeh Behzad , Małek Emilian , Grandi Giulio
Published: October 2023

Background:Halicephalobus gingivalisis a nematode with zoonotic potential which can cause fatal opportunistic infections in a wide variety of mammals. The parasite has never been diagnosed in Sweden, in any species, prior to the presented case.Case presentation:An imported 21-year-old Icelandic mare developed severe neurological symptoms. The horse was eventually euthanized and submitted for post-mortem examination where severe lesions in the kidneys was noted. Samples for histological examination were submitted, which revealed the presence ofH. gingivalisin both renal and brain tissue. Phylogenetic analysis of the parasite determined it to belong to Linage 1.Conclusions:With the occurrence ofH. gingivalisin Sweden, the disease should be added to the list of differential diagnoses in cases with acute onset of neurological disease in both horses and mammals including humans.
Predictors of postoperative recurrence of pheochromocytoma: A monocentric study
Authors: Li Zhuoran , Lai Dong , Jia Yuqi , Luo Jin , Ma Xin , Zhang Xu , Tang Lu , Li Xintao , Wang Baojun
Published: October 2023

Background
To discuss the risk factors affecting the recurrence of pheochromocytoma after surgery.
Methods
We retrospectively reviewed patients who were hospitalized and underwent surgery for PCC between January 2012 and December 2020 at Chinese PLA General Hospital. Inclusion criteria were pathological diagnosis of PCC and availability of follow up.
Results
In total, 451 patients met the inclusion criteria. The average age was 45.89 years, and the median tumor diameter was 5.75 cm. The mean recurrence time was 34.24 months. Of the 451 patients receiving surgery, there were 35 recurrent cases (7.85%). The univariate test showed that age, hypertension, history of PCC recurrence, Ki-67 index ≥ 5, bilateral tumor, duration of phenazopyridine administration, DBP at admission, open operation, intraoperative HR minimum, intraoperative times of HR over 120, times of instability, and intraoperative bleeding were associated with recurrence after radical surgery. Multivariate COX regression analysis of age (HR(hazard ratio) 0.95), hypertension (HR 7.14), history of PCC recurrence (HR 69.35), family history of hypertension (HR 16.30), bilateral tumor (HR 7.38), tumor size (HR 1.05), times of instability (HR 114.91) and length of instability in minutes (HR 1.12) were the independent influences on recurrence after pheochromocytoma resection.
Conclusions
Age, hypertension, history of PCC recurrence, family history of hypertension, bilateral tumor, tumor size, intraoperative times of instability, and intraoperative instability minutes were independent influences on recurrence after pheochromocytoma resection.