bluuebunny/crossref_metadata_2025 huggingface dataset:
Educação ambiental em cursos de ciências contábeis da paraíba
Authors:   , Oliveira Karla Eloisse Alencar de
Published: January 2025

Nas últimas décadas observa-se em todo o mundo uma crescente preocupação
com a questão ambiental. A Educação Ambiental vem sendo apontada como uma
importante ferramenta que contribui para a participação da sociedade na preservação
e conservação do meio ambiente, promovendo assim a difusão do conhecimento. A
Educação Ambiental é um tema interdisciplinar e transversal que deve ser adotada
junto a formação educacional. Como consta na Lei nº 9.795/99 (Política Nacional de
Educação Ambiental), as instituições educativas devem promover a educação
ambiental de maneira integrada aos programas educacionais que as mesmas
desenvolvem. Ao tempo em que a dimensão ambiental, também, deverá constar dos
currículos de formação de professores e em todas as disciplinas, no intuito de atender
os objetivos da respectiva lei. A presente pesquisa buscou analisar como a temática
ambiental vem sendo trabalhada nos cursos, presenciais, de Ciências Contábeis das
Universidades Públicas do Estado da Paraíba. Trata-se de uma pesquisa descritiva e
de natureza qualitativa, pois descreveu as características dos sujeitos estudados
através da interpretação e relação dos fatos. Quanto aos procedimentos de coleta, foi
realizado um estudo de campo com as Instituições de Ensino Superior Públicas do
Estado da Paraíba, onde foram entrevistados os Coordenadores e o Corpo Docente
do curso de Ciências Contábeis das referidas IES. Foram utilizados, como
instrumentos de coleta de dados, dois roteiros de entrevistas, um aplicado aos
Coordenadores e outro ao Corpo Docente, composto por quesitos subjetivos. Ainda,
foi realizada uma análise documental, onde foram coletadas, através de um checklist,
informações referentes aos PPC’s dos cursos pesquisados. Os resultados obtidos
com o presente estudo mostram que ainda são grandes os desafios para uma inserção
eficiente da temática ambiental nos currículos dos cursos de Ciências Contábeis da
Paraíba. A análise realizada com os coordenadores dos cursos pesquisados mostra
que a temática vem sendo inserido nos cursos. Essa inserção se dá por meio tanto
através dos conteúdos trabalhados nas disciplinas dos cursos e através de pesquisas
realizadas pelos docentes das IES. As entrevistas realizadas com os docentes do
curso apontam que esses não possuem dificuldades na inserção do tema nas
disciplinas lecionadas; apontam que realizam tal inserção de forma interdisciplinar e
transversal e, ainda, asseguram que os discentes participam de forma efetiva e que
conseguem aplicar na prática os conceitos discutidos em sala. Através da análise
realizada com os PPCs dos cursos pesquisados chegou-se à conclusão de que as
falas dos coordenadores divergem no sentido de que os coordenadores apontam que
são realizadas diversas atividades de ensino, pesquisa e extensão, além de eventos
e ações pontuais relacionadas a temática, o que não pode ser observado no referido
documento.
Percepção de alunos de graduação acerca de como a educação ambiental vem sendo trabalhada na universidade federal rural do semi-árido
Authors:   , Lima Flávia Giglianne Freitas
Published: January 2025

A Educação Ambiental tem o propósito de promover mudanças nos valores, atitudes, hábitos e comportamentos dos cidadãos através do equilíbrio entre o homem e o meio ambiente. Seguindo esse viés as Instituições de Ensino Superior estão cada vez mais preocupadas e engajadas em incorporar esta formação em suas atividades acadêmicas. Incorporando modelos de ensino e aprendizagem cada vez mais voltados para solução dos problemas ambientais, as instituições estão reorganizando suas atividades de educação, pesquisa e extensão em direção à sustentabilidade. Portanto, é interessante avaliar se essa temática vem sendo trabalhada nas instituições, se é perceptível por parte dos discentes e examinar as suas relações na construção de valores, atitudes e comportamentos ambientalmente responsáveis. Desta forma, o objetivo desta pesquisa é examinar as relações existentes entre a percepção da inserção da Educação Ambiental e as atitudes, valores e comportamentos ambientalmente responsáveis dos alunos dos cursos de graduação da UFERSA. Por meio da adaptação do estudo de Silva (2014), em que se realizou a pesquisa de campo, os dados foram obtidos através de questionários eletrônicos que foram enviados por meio do Sistema integrado de gestão de atividades acadêmica. A análise dos dados foi realizada através de estatística descritiva e análise fatorial exploratória. Na análise descritivas dos resultados obtidos, em que o primeiro construcuto analisado foi o comportamento ecológico, apresentou duas dimenções positivas: a economia de água e energia e limpeza urbana. No segundo constructo dos valores ecológicos, as três dimensões biosférico, altruístico e egoísta foram estatisticamente positivas. Na constructo das atitudes ecológicas, a dimensão atitudes antropocêntricas foi a mais significativa entre todas. A análise descritiva da escala de percepção da inserção da Educação Ambiental revela que os alunos percebem as medidas implementadas no campus. Na análise fatorial exploratória a Educação Ambiental teve uma correlação estatisticamente significativa com constructo comportamento ecológico, as dimensões economia de água e energia, limpeza urbana e ativismo-consumo foram as que apresentaram uma correlação mais forte. No constructo dos valores as três dimensões biosférico, altruístico e egoísta se correlacionaram significativamente com todas as dimensões de percepção da Educação Ambiental e no constructo das atitudes as dimensões antropocêntrico e acocêntrico apresentaram correlação significativa.
Avaliação do vigor de sementes crioulas de milho (zea mays l.) utilizando testes tradicionais e análise de imagens
Authors:   , Silva Kelem Cristiany Nunes
Published: January 2025

As sementes crioulas são variedades adaptadas ou produzidas geralmente por agricultores familiares, consideradas recurso básico e de grande importância para autonomia, segurança alimentar e nutricional, necessárias para permanência do homem no campo. A avaliação da qualidade das sementes através de testes de vigor representa um auxílio importante para esses agricultores, com o intuito de classificar esses materiais em diferentes níveis de vigor. Dessa forma, objetivou-se avaliar a eficiência de testes físicos, fisiológicos e sanitário na classificação de lotes de sementes crioulas de milho (Zea mays L.) em comparação com uma cultivar comercial, como também comparar os resultados das análises de imagens de plântulas dessas sementes com as análises fisiológicas tradicionais. Foram avaliados 24 lotes de milho crioulo adquiridos em sete regiões do Oeste Potiguar e uma cultivar comercial distribuída pelo Programa Banco de Sementes do Estado do RN. A qualidade física foi determinada pelos seguintes testes: grau de umidade, pureza física, determinação de outras sementes e peso de mil sementes, e para avaliação da qualidade sanitária realizou-se o exame de sementes infestadas. A qualidade fisiológica foi determinada pelo teste de germinação, primeira contagem, comprimento da parte aérea e da raiz, massa seca da parte aérea e da raiz, emergência, índice de velocidade de emergência, envelhecimento acelerado, condutividade elétrica e lixiviação de potássio. Através do Sistema de Análise de Plântulas (SAPL) foram
calculados os índices de comprimento de plântulas, uniformidade, crescimento e vigor. Os testes físicos e fisiológicos são eficientes na classificação dos lotes em diferentes níveis de vigor, no entanto, o sistema de análise de plântulas não estratifica os lotes de forma semelhante aos testes tradicionais. A cultivar comercial usada no presente estudo, apresenta potencial fisiológico inferior em relação às sementes crioulas na maioria dos testes realizados.
Empagliflozin Pharmacotherapy: An Updated Overview
Authors: Tolou-Ghamari Zahra
Published: January 2025

It has been estimated that by 2030, the number of patients with diabetes is expected to rise to 552 million. Moreover, an estimated 20 million new
cancer cases were reported in 2022, and 64 million people worldwide are currently suffering from heart failure. Recently, there has been an
increasing interest regarding the prescription of a drug that was approved for use in May, 2014, which is called empagliflozin. Up to now, limited
data is available on the efficacy, safety, and side effects of empagliflozin against a variety of diseases, including diabetes, heart failure, and cancer.
Therefore, this study aimed to gather relevant data on empagliflozin by searching electronic databases, such as Web of Science, Scopus, Pubmed,
and Cochrane Library, through October 9th, 2024. One hundred forty-four relevant studies, including review articles, clinical trials, and case
reports, were assessed. It was found that orally, once daily use of empagliflozin, in addition to the glucose-lowering effect, suppresses
inflammation and improves diastolic function. Empagliflozin inhibits breast cancer stemness by inactivating transcription factors and enzyme
pyruvate kinase M2 via enhanced miR-128-3p expression. By inhibiting the sodium-glucose cotransporter, the drug has a well-known safety and
efficacy in patients with breast cancer, type 1 or 2 diabetes, acute septic renal injury, renal disease, and heart failure. Regarding efficacy,
empagliflozin acts as an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, sodium-glucose cotransporter type 2 inhibitor,
vascular resistance prevention, and albuminuria-lowering agent. A recently published observational study confirmed the efficacy and safety of
empagliflozin in improving kidney function and glycemic profile and reducing cardiovascular events in diabetic patients with advanced chronic
kidney disease. In addition, empagliflozin is efficient as a blood pressure-lowering agent in patients with hypertension and those at higher risk of
cardiovascular disease. Furthermore, for patients with diabetes and obesity, empagliflozin reduces the progression of kidney disease and improves
clinical conditions in those with high blood pressure. It has a beneficial effect on hemoglobin A1c (HbA1c), body weight, glucose variability, and
total daily insulin use in people with type 1 diabetes. Itching or redness of the genital area, genital infection, hematuria, difficulty in urination,
bladder pain, painful sexual intercourse, peripheral amputations, and Fournier’s gangrene (rarely informed adverse effects) are the most commonly
reported side effects. Additionally, pancreatitis, bad odor, and suicide attempts were recorded in some published case reports. Further evidencebased
polypharmacological benefits of empagliflozin associated with its nephroprotective, cardioprotective, and glucose-lowering effects and in
cancer were reported to be advantageous.
Basic Fibroblast Growth Factor-releasing Polyglycolic Acid Duras Improve
Neurological Function after Cerebral Infarction
Authors: Ito Yoshiro , Oyane Ayako , Tsurushima Hideo , Matsumaru Yuji , Ishikawa Eiichi
Published: January 2025

Objective:

Regenerative therapy using stem cells to treat cerebral infarction is currently
in the research phase. However, this method is costly. It also faces other significant challenges, including
optimization of timing, delivery methods, and dosage. Therefore, more practical and effective
therapies are required. Bioabsorbable artificial dura mater made from nonwoven Polyglycolic
Acid (PGA) fabric is used clinically to treat cerebral infarction. Basic Fibroblast Growth Factor
(bFGF) has attracted considerable attention as a potential therapeutic candidate for the treatment
of cerebral infarctions. In this study, we aimed to prepare a bFGF-releasing PGA dura mater and
investigate its therapeutic efficacy for the recovery of neurological function in a mouse model of
focal cerebral infarction.

Methods:

An artificial dura mater (Durawave) made from nonwoven PGA fabric was subjected to
oxygen plasma treatment, followed by bFGF adsorption. The release of bFGF from the resulting
PGA dura mater was evaluated in vitro using enzyme-linked immunosorbent assays. bFGF-releasing
PGA dura mater was placed at the site of induced cerebral infarctions in mice. Neurological
function was assessed 14 days after insertion, followed by a histological assessment.

Results:

The prepared PGA dura mater released bFGF in a dose-dependent manner. Neurological
function in the bFGF-treated groups was significantly better than that in the control group. bFGFreleasing
PGA dura mater also significantly increased the number of neural progenitor cells in the
peri-infarct cortex and striatum and showed a trend toward promoting angiogenesis.

Conclusion:

bFGF-releasing PGA dura mater improved neurological function in a mouse model
of focal cerebral infarction.
Molecular Mechanism and Research Progress of Sphingolipid Metabolism in Regulating Radiation-induced Apoptosis Using Pan-cancer Analysis
Authors: Yuan Xiang , Liu Haiqing , Li Chuanjiang , Zhang Yuqin , Xie Chen , Ge Xiurui , Wang Kai , Li Yiyi
Published: January 2025

Radiotherapy stands as a cornerstone in cancer therapy, with nuclear DNA acknowledged as the principal target molecule for radiation-induced cellular demise or injury. Nonetheless, an expanding body of contemporary research elucidates the significant contri-bution of sphingolipids to radiation-induced cell death, particularly in modulating radiation-induced apoptosis. Radiation can instigate apoptosis through multiple pathways of sphin-golipid metabolism, encompassing the activation of ceramide synthase, acid sphingomyelin-ase, neutral sphingomyelinase, sphingosine-1-phosphate lyase, and sphingosine-1-phosphate phosphatase, and the inhibition of sphingosine kinase-1. The disruption of sphingolipid me-tabolism leads to an increase in pro-apoptotic sphingolipid ceramide and sphingosine and a decrease in anti-apoptotic sphingolipid sphingosine-1-phosphate, which ultimately triggers apoptosis in tumor cells. The diminished or absent response of sphingolipids to radiation rep-resents one of the contributors to radioresistance. In this context, numerous interventions tar-geting sphingolipids have been utilized to augment radiosensitivity in tumor tissue and miti-gate radiation-induced damage in normal tissue, demonstrating efficacy both in vitro and in vivo. Sphingolipids have also emerged as promising biomarkers for evaluating the response to radiotherapy in patients. Attaining a comprehensive understanding of sphingolipid metab-olism in radiation-induced apoptosis holds the potential to offer an effective strategy for en-hancing the efficacy of radiotherapy and mitigating resistance to such treatment.
Synthesis, X-Ray Structure, Characterization, Antifungal Activity, DFT, and Molecular Simulation of a Novel Pyrazole Carboxylic Acid
Authors: Tighadouini Said , Yamari Imane , Roby Othmane , Y. A. Alzahrani Abdullah , Abchir Oussama , Nait Irahal Imane , Saddik Rafik , Ferbinteanu Marilena , Chtita Samir
Published: January 2025

Background:

The search for new antifungal agents is critical due to the rising resistance
of fungal pathogens to existing treatments. This study focuses on the synthesis and evaluation of a
novel compound, 1-benzyl-5-methyl-1H-pyrazole-3-carboxylic acid (compound L1), as a potential
antifungal agent.

Methods:

Compound L1 was synthesized and characterized using a range of analytical techniques,
including 1H^1H1H NMR, 13C^{13}C13C NMR, FT-IR, GC-MS, and X-ray single crystal diffraction
(XRD). The antifungal activity of the compound was assessed in vitro, and its molecular
structure was studied using Density Functional Theory (DFT). Molecular docking and dynamics
simulations were conducted to evaluate the interaction of the compound with sterol 14-alpha demethylase
(CYP51) from Candida albicans. ADME/Tox evaluations were also performed to assess the
drug-like properties of compound L1.

Results:

Compound L1 exhibited moderate antifungal activity with an IC50 value of 34.25 μg/mL.
DFT studies confirmed the highly stable molecular structure of the compound. Molecular docking
and dynamics simulations demonstrated that compound L1 had a higher affinity and stability when
forming complexes with the crystal structure of CYP51, particularly in interaction with the tetrazole-
based antifungal drug candidate VT1161 (PDB ID: 5TZ1). ADME/Tox evaluations indicated
favorable drug-like properties for compound L1.

Conclusion:

The results suggest that compound L1 is a promising antifungal candidate, showing
greater potential than fluconazole in the conducted evaluations. Further studies are warranted to
explore its full therapeutic potential.
PCOS-induced Cancers: A Brief Insight on the Relevance of Androgen
and Obesity
Authors: Gupta Shreya , Rajput Divyanshu , Sood Ratima , Bhatia Rohit
Published: January 2025

This review aims to provide an updated overview of the relationship between Polycystic
Ovary Syndrome (PCOS) and the development of various types of cancers. PCOS, a condition affecting approximately 5–10% of women of reproductive age, is characterized by oligo- or anovulation, hyperandrogenism, insulin resistance, type II diabetes, hyperlipidemia, obesity, and chronic
stress. These factors collectively contribute to an increased risk of cancer in women with PCOS. The
hormonal and metabolic imbalances associated with PCOS, such as elevated androgen levels and
disrupted ovarian function due to insulin resistance, lead to chronic anovulation. This, in turn,
heightens the risk of endometrial cancer. Women with PCOS are reported to have a 2.7-fold increased risk of endometrial cancer compared to those without the condition. Additionally, emerging
evidence suggests a link between PCOS and an increased risk of ovarian and breast cancers. Obesity,
a common comorbidity in PCOS, exacerbates these risks by elevating levels of ovarian and adrenal
androgens, as well as unbound testosterone, which intensifies the clinical and hormonal disturbances
of PCOS. Excessive estrogen exposure, chronic anovulation, and elevated androgen levels are critical factors in cancer development. Furthermore, the hormonal profile of PCOS, characterized by
elevated androgen, estrogen, and Sex Hormone-Binding Globulin (SHBG) levels, has been implicated in the pathogenesis of breast cancer. In summary, this review highlights the role of hyperandrogenism, obesity, and related metabolic dysfunctions in the development of endometrial, ovarian, and
breast cancers in women with PCOS. Understanding these mechanisms underscores the need for
targeted strategies to mitigate cancer risks in this population.
Dyspnea and Heart Failure: The Role of the Diaphragm
Authors: Corrêa Nascimento Pablo Marino , Luiz Ribeiro Mario , Nascimento Lourenço Bernardo , Villacorta Humberto , Lagoeiro Jorge Antonio José , Novaes Rocha Nazareth de , Martins Wolney de Andrade
Published: January 2025

Background:

Dyspnea and exertional intolerance are the most common clinical manifestations
of Heart Failure (HF). One of the possible mechanisms of both symptoms in HF patients
is weakness of the inspiratory muscles.

Aim:

Because the diaphragm is the main inspiratory muscle, this review aimed to investigate the
contribution of diaphragmatic function to the genesis of dyspnea or exercise intolerance in HF
patients.

Methods:

Original articles, clinical trials, and cohort or case-control studies published between
January 2003 and March 2023 were included. The population, variables, and outcome strategy
were the basis of this review, including studies that assessed HF patients, diaphragmatic function,
and dyspnea or exercise tolerance. The PubMed/MEDLINE, Embase, and BVS/LILACS
databases were searched.

Results:

A total of 353 articles were identified from electronic databases. After removing duplicate
articles and screening based on titles, abstracts, and full texts, nine articles were included in
the qualitative synthesis of this review. These studies were quite heterogeneous in their methodologies;
however, most, except two, demonstrated an association among diaphragmatic dysfunction,
dyspnea, and exertional intolerance in HF patients.

Conclusion:

Although few studies have assessed the contribution of diaphragmatic function to
dyspnea and exertional intolerance in HF individuals, the vast majority of articles included in
this review found such an association, especially when diaphragmatic function was assessed using
ultrasound.
Bioinformatics Tools and Computational Methods Applied of HIV/AIDS Envelope Glycoproteins
Authors: Polanco Carlos , Rios Castro Martha , Uversky Vladimir N. , Huberman Alberto , Pimentel-Hernández Claudia , Martínez-Garcia Mireya , Buhse Thomas , Hernández-Lemus Enrique , Roldan Gomez Francisco J. , Nájera Sergio Enrique Solís , González Juan Luciano Díaz , Alarcon Gilberto Vargas
Published: January 2025

Background:

Since the 1980s, public health, society, and the global economy have been
severely impacted by HIV/AIDS, resulting in countless deaths and weakened health systems worldwide.
Exclusion and unemployment have been caused by social stigma, while economic consequences,
including reduced labor productivity and increased healthcare costs, have been observed, particularly
in regions with fragile health systems.

Objective:

Computational studies were conducted to characterize HIV/AIDS envelope glycoproteins
and differentiate them from other protein groups.

Methods:

A series of computational tools, including specialized genomics software, were utilized to
assess the likelihood of each glycoprotein sequence being intrinsically disordered (PIDP), and its
polarity profile (PIM 3.0v) was analyzed.

Results:

Distinct patterns were revealed across all HIV/AIDS envelope glycoproteins by the analysis
of the PIM 3.0v and PIDP profiles, facilitating the identification of structural and morphological
similarities among the proteins.

Conclusion:

HIV/AIDS glycoproteins are effectively differentiated by the PIM 3.0v profile, which
may serve as a tool for their identification. This bioinformatics research has been shown to enhance
our understanding of HIV/AIDS.
Development and Preliminary Validation of a Questionnaire to Assess Perceptions on the Implementation of UN CRPD Principles Concerning Social Inclusion and Participation of Persons with Disabilities in Municipalities
Authors: Pinna Samantha , Tusconi Massimo , Atzeni Michela , Perra Alessandra , Leonetti Valerio , Cossu Giulia , Primavera Diego , Mereu Noemi Maria , Petretto Donatella Rita , Preti Antonio , Pelosin Elisa , Eskin Mehmet , Migliaccio Gian Mario , Carta Mauro Giovanni , Sancassiani Federica
Published: January 2025

Background

The present study aims to evaluate the preliminary content and face validity of the “Perceptions on the Implementation of the CRPD in muniCIpalities Questionnaire (PICI-Q),” a self-report questionnaire built to assess the perceptions on how effectively municipalities implement the CRPD principles concerning social inclusion and participation of persons with disabilities in municipalities.

Methods

A two-step Delphi methodology was used to build the questionnaire and assess its content and face validity. A group including health professionals, academics, experts in psychometrics, persons with disabilities and local policymakers was involved in building the questionnaire according to the CRPD articles regarding social inclusion and active participation of persons with disabilities. Two pools of experts assessed the content and face validity and lay stakeholders, respectively.

Results

An average content validity index of 0.95 was obtained, with no items removed. Regarding face validity, all items achieved high scores, ranging from 17 to 21, with a face validity index of 0.95.

Conclusion

The PICI-Q is a promising tool for assessing perceptions of CRPD implementation in municipalities. Its robust preliminary validation suggests it could support local authorities in designing and improving policies and interventions aligned with the CRPD principles of social inclusion and participation for persons with disabilities.
Processed Products of Aconitum soongaricum Stapf. Inhibit the Growth of Ovarian
Cancer Cells In vivo via Regulating the PI3K/AKT Signal Pathway
Authors: Li Xiaojuan , Tang Xinle , Chen Liang , Cao Xingxing , Ailimujiang Reziya , Li Qian , Zhao Feicui
Published: January 2025

Introduction/Objective:

The alkaloids of songorine, aconitine, and benzoylaconitine, as the processed
products of Aconitum soongaricum Stapf., can significantly inhibit the migration and invasion of ovarian cancer
cells in vitro. Herein, we studied the in vivo role and mechanism of these natural products in processed A. soongaricum
Stapf.

Methods:

A xenograft tumor model was constructed. Tumor volumes and weights were calculated. HE staining
assessed the histopathological changes of tumors. Inflammatory factors were detected using ELISA. Gene and
protein expressions of E-cadherin, N-cadherin, PIK3CA, and AKT1 proteins were measured using RT-qPCR and
immunohistochemistry. Protein expressions of E-cadherin, N-cadherin, PIK3CA, AKT1, p-PIK3CA, and p-
AKT1 proteins were detected using western blot analysis.

Results:

Songorine, aconitine, and benzoylaconine significantly inhibited the growth of tumors as evidenced by
decreased tumor volume and weight. The extent and scope of tumor cell necrosis were less in the songorine group
compared to the vehicle group. Songorine, aconitine, and benzoylaconine significantly reduced IL-6, IL-1β, and
TNF-α levels. Furthermore, songorine, aconitine, and benzoylecgonine induced down-regulation of N-cadherin and
AKT1 mRNA in comparison to the vehicle group. Meanwhile, songorine, aconitine, and benzoylaconine also significantly
reduced N-cadherin, p-PIK3CA, and p-AKT1 proteins, while upregulating E-cadherin protein expression in
comparison to the vehicle group. These effects were further enhanced when combined with the PI3K inhibitor
LY294002.

Conclusion:

Songorine, aconitine, and benzoylaconine may inhibit ovarian cancer growth in vivo by blocking the
PI3K/AKT signaling pathway. Our findings may provide evidence for the clinical application of the processed products
of Aconitum soongaricum Stapf. in ovarian cancer treatment.
Low-loss Low-rank Representation for Medical Image
Analysis
Authors: Zhang Nan , Xi Maolong
Published: January 2025

Background:

There has been extensive research on low-rank representation methods,
and we firmly believe that this approach holds tremendous potential in addressing image-related
challenges.

background:

There has been extensive research on low-rank representation methods, and we firmly believe that this approach holds tremendous potential in addressing image-related challenges.

Objective:

Medical image databases.

Method:

We present low-loss low-rank representation(LLRR) to build a low-loss low-rank classifier
(LLC) and a low-loss Low-rank discriminant projection(LLDP).

Results:

The LLC algorithm exhibits a disease classification accuracy that is superior, with a maximum
difference of 10%, compared to other algorithms. After pairing the feature extractors with a
Nearest Neighbor Classifier, LLDP achieved a maximum 5.6% advantage in disease classification
accuracy. In other words, feature extraction and classification methods can be constructed based
on the representation method proposed, and the performance of LLRR is superior.

Conclusion:

The experimental results indicate that LLDP and LLC consistently outperform other
state-of-the-art methods, thus establishing LLRR as an effective data representation method
Fatigue Reliability Prediction of TBM Main Bearings Based on Non-dimensional Interference Model
Authors: Chen Shihui , Zhao Jian , Liu Shiming , ling jingxiu , Zhang Rongchang
Published: January 2025

Introduction:

To predict the fatigue life of the main bearing of the TBM cutter head. In
this paper, a patent method for a different dimension interference model combining numerical simulation
platform and numerical statistics is proposed to further improve the efficiency and accuracy
of the reliability analysis of the main bearing.

Method:

The load from the cutter head is transmitted to the bearings, thereby identifying the critical
locations and maximum stress points of the main bearings. The load history of the dangerous
locations of the main bearings is obtained and combined with the quasi-static method, the stress
history of the dangerous locations is derived. Combining stress-strength interference models and
statistical theory, this study applies a non-dimensional interference model to predict the reliability
of TBM main bearings under specific operating conditions.

Result:

After statistical analysis, the stress amplitude distribution of the main bearings conforms
to the Weibull distribution, with a shape parameter of 0.61 and a scale parameter of 68.39; The
lifetime distribution follows a lognormal distribution. By utilizing the non-dimensional interference
model, the reliability curve of the main bearings is derived. When the operating cycles reach
6.8e6, the reliability is 0.9, and the lifespan remains around 20,000 hours, meeting the engineering
requirements.

Conclusion:

Therefore, The model and patent for the method proposed in this paper can calculate
the fatigue reliability of the main bearing quickly, ensure the accuracy of the analysis results, and
provide certain theoretical support for the prediction of its safety and fatigue reliability.
Silymarin and Isoniazid Combination for the Treatment of Drug-Resistant
Tuberculosis: A Mini Review
Authors: Jatav Pooja , Shrivastava Ruchi Khare
Published: January 2025

Tuberculosis remains a global health concern, necessitating the exploration of
novel therapeutic strategies. Multidrug-resistant and extensively drug-resistant strains of
Mycobacterium tuberculosis pose a growing challenge in tuberculosis treatment. Drug resistance can reduce the effectiveness of isoniazid, a commonly used first-line anti-tuberculosis drug, in treating tuberculosis. Silymarin, a flavonoid complex obtained from milk thistle, has drawn great interest owing to its rich anticancer, antioxidant, anti-inflammatory, and
hepatoprotective properties. Recent studies have indicated that silymarin, when used with
first-line anti-TB drugs such as isoniazid, may strengthen the treatment. This mini-review
intends to assess the currently available evidence base and the extent to which it supports
the use of silymarin as synergistic with isoniazid in the treatment of tuberculosis. We further
elaborate on pharmacological activities and describe possible ways silymarin would exert
an antibacterial action against Mycobacterium tuberculosis, the causative microorganism of
tuberculosis. Further analysis is conducted on in vitro, in vivo, and clinical studies that contain information regarding the effectiveness and security of this drug combination. Finally,
we consider the barriers, patterns, and contours connected with silymarin-isoniazid combination therapy development, silymarin justification dominance formulations, reliable doses,
and necessary clinical trials to verify silymarin efficacy and safety in different categories of
patients suffering from tuberculosis.
The Impact of Hemp Fiber Filler on PE-wax-modified Compression-molded
UHMWPE; A Mechanical Characterization
Authors: Janusz I. , Tatara R. A. , Vaezi M.
Published: January 2025

Introduction:

Hemp and other natural fibers are seeing greater use in the industry due
to their useful mechanical properties and sustainability. Natural fibers can reinforce or fill polymers to reduce cost and increase biodegradability. Ultra-high molecular weight polyethylene
(UHMWPE) exhibits exceptional toughness and is capable of being mixed with natural fibers

Materials and Methods:

In this study, hemp fiber, in powder form, has been blended with
UHMWPE powder and processed by compression molding to evaluate mechanical strength
properties. The effects of adding low molecular weight polyethylene wax (PE-wax), a property
modifier, were also examined. The hemp content of the compositions was 0, 20, 40, 60% w/w,
with and without the wax.

Results:

Consistent with filler behavior, the addition of hemp significantly reduces the ultimate
and yield tensile strengths as well as the elongation at break; the effect increases with more
hemp. PE-wax improves performance at 40% and 60% w/w hemp, compared to the no wax condition. The presence of hemp increases the elastic modulus for 20% and 40% w/w hemp, and
PE-wax improves the elastic modulus at all hemp concentrations. Compressive strength declines
as hemp content increases, and the wax raises the performance at all hemp levels, nearly doubling the 20% w/w hemp strength. Shore type D hardness values steadily decline with hemp content, with a 60% loss in hardness, from the pure UHMWPE baseline to the 60% w/w hemp sample.

Conclusion:

The simplified process outlined in this study produced materials that are fit for use
in engineered applications. The process was also much simpler than traditional hand lay-up techniques, making it attractive for use in industrial applications.
Morte e salvação da alma nos testamentos dos portugueses da vila de Cachoeira (Bahia, século XVIII): notas de investigação
Authors: Santana Tânia Maria Pinto de
Published: January 2025

he objective of this article is to analyze the pious dispositions of the residents of Vila de Nossa Senhora do Rosário do Porto da Cachoeira and its terms. The sources we looked at were their wills, written throughout the 18th century. Through this analysis, we seek to understand the practices related to care for the salvation of the soul observed in the wills – specifically the pious legacies (requests for shrouds, processions, funeral masses, burials and suffrages). We investigated the record of their last wishes, relating to the salvation of their souls and the shortening of their time of purgation in Purgatory. Through the analysis of the pious legacies, requested by the village residents and their terms, we also intend to analyze the role played by the parish community in the process of religious framing of these communities, highlighting the active role that the laity, specifically the kingdom settlers, had within them.
A ideia de salvação nos contos "Famigerado", "A terceira margem do rio" e "A benfazega", de Guimarães Rosa
Authors: Schneider Ivana
Published: January 2025

This essay aims to analyze the way Guimarães Rosa addresses the theme of
salvation in three of his narratives from Primeiras Estórias. From varied perspectives, each
narrative points to different concerns regarding the conception of salvation. “Famigerado”
evokes the multiple meanings of a word as a tool for salvation; “A Terceira Margem do Rio”
deals with the relationship between salvation and perdition within a scenario where these
terms seem to blur; “A Benfazeja” takes into account not only the concept of salvation but
also evokes the idea of guilt and sacrifice.
Writing under the 'Auto/biographical Demand' in Deborah Feldman’s Unorthodox (2012) and Exodus (2015)
Authors: Haragos Szidonia
Published: January 2025

This article offers a reading of Deborah Feldman’s memoir sequel, Unorthodox: The Scandalous Rejection of My Hasidic Roots (2012) and Exodus: A Memoir (2015), through the lens of what Leigh Gilmore calls 'the auto/biographical demand'. It argues that Feldman writes under the 'auto/biographical demand' as the grandchild of Hungarian Holocaust survivors and redeploys the inherited story of gendered suffering during the Holocaust in order to reconfigure her own Jewish American identity. I employ Gilmore’s concept to reflect upon the writing of the self in Feldman’s memoir sequel in terms of narrative entanglement, postmemory, and third generation transmission of collective trauma. In addition, the article reflects on Feldman’s text as an echo chamber of the profoundly controversial Kastner affair during the Holocaust in Hungary and its transatlantic reverberations.
KEEFEKTIFAN PEMBELAJARAN KOOPERATIF TIPE THINK-PAIR-SHARE DITINJAU DARI PENINGKATAN KETERAMPILAN BERPIKIR KRITIS PESERTA DIDIK SMA
Authors: Jauhari Latif , Pujianto Pujianto
Published: January 2025

Abstrak Penelitian ini bertujuan untuk mengetahui (1) Perbedaan peningkatan keterampilan berpikir kritis antara peserta didik yang diberikan pembelajaran dengan model pembelajaran kooperatif tipe Think-Pair-Share dan peserta didik yang diberikan pembelajaran dengan model pembelajaran konvensional materi momentum dan impuls,dan (2) Peningkatan keterampilan berpikir kritis peserta didik yang diberikan pembelajaran dengan model pembelajaran kooperatif tipe Think-Pair-Share pada materi momentum dan impuls. Jenis penelitian yang digunakan adalah eksperimen dengancontrol group pre-test-posttest design. Populasi penelitian ini adalah peserta didik kelas X MIPA di SMAN 1 Tempel tahun pelajaran 2017/2018. Materi fisika yang diajarkan yaitu momentum dan impuls. Instrumen pengumpulan data yaitu soal tes keterampilan berpikir kritis, lembar observasi keterlaksanaan RPP, dan lembar validasi. Teknik analisis data menggunakan analisis deskriptifdan nilai standard gain. Hasil penelitian menunjukkan bahwa (1) ada perbedaan peningkatan keterampilan berpikir kritis antara peserta didik yang diberikan pembelajaran dengan model pembelajaran kooperatif tipe Think-Pair-Share dengan peserta didik yang diberikan pembelajaran dengan model pembelajaran konvensional pada materi momentum dan impuls di SMAN 1 Tempel, dan (2) Peningkatan keterampilan berpikir kritis peserta didik yang diberikan pembelajaran dengan model pembelajaran kooperatif tipe Think-Pair-Share sebesar 0,53 (sedang). Kata kunci: pembelajaran kooperatif tipe Think-Pair-Share, keterampilan berpikir kritis, momentum dan impuls. Abstract This research aims to determine (1) the differences of critical thinking skills between students which follows the physics instruction using cooperative learning type think-pair-share model and the conventional learning model, (2)the improvement ofcritical thinking skills of high school students which follows the physics learning using cooperative learning type think-pair-share model. This research is an experimental research with the control group pretest-posttest design. The population of this research are first grade students of SMA N 1 Tempel in academic year 2017/2018. The matter physics that taught is impulse and momentum. The instrument of data collection aretest of critical thinking skills, observation sheet of RPP implementation, and validation sheet. Data analysis using normalized gain score and descriptive analysis. The finding of the research shows that: (1) there were differences of critical thinking skills between students which follows the physics instruction using cooperativelearning type think-pair-share model and the conventional learning model, and (2) improvement of critical thinking skills of high school students which follows the physics instruction using cooperative learning type think-pair-share model equal to 0,529 with medium category. Keywords: Cooperative learningtype think-pair-share, critical thinking skills,impuls and momentum
Prevalence of Speech and Language Delay in Early School-Aged Children
Authors: Lee Eun Kyoung , Choi Seong Hee
Published: January 2025

Purpose: Elementary school is a crucial time for children’s language development as they acquire skills essential for learning. This study investigates the prevalence of speech and language development delays among early elementary school children in South Korea, providing insight into the speech and language development challenges faced by young students in the country.Methods: Ten speech-language pathologists conducted a screening test for speech and language disorders on a sample of 381 elementary school children aged 7 to 9 (boys 200, girls 181) from the Busan and Gwangju areas in Korea. They used the Receptive and Expressive Vocabulary Test (REVT) and the Urimal Test of Articulation and Phonology Test (UTAP).Results: Among the 381 children who underwent the test, 170 were identified as being at risk for having speech or language delay or disorders. This suggests that approximately 44.6% of the general population may exhibit speech or language problems. The prevalence of language delays was 35.6% for receptive vocabulary, 27.6% for expressive vocabulary, and 6.04% for speech delays. For boys, language delays were expected to range from 12.9% to 19.7%, while for girls, it was expected to be between 14.6% and 16.0%. In contrast, for articulation issues, 3.9% of boys and 2.1% of girls were found to have speech problems. Most of these children had not only language issues but also some speech disorders. Approximately 4.2% of the identified children had both speech and language problems, 38.6% had only language problems, and 1.8% had only speech problems.Conclusions: The high prevalence of language development delays among early elementary school children underscores the critical need for proactive language screening and intervention in the school environment.
Proceso De Lecto Escritura Y Su Influencia En La Formación Integral De Los Niños En Educación Inicial
Authors: Barraza Sarmiento, Danitza Marcela , Villalba Atencia Angelica , Oyaga Martínez Rafael Fernando , Venegas Polo Marco , Ortiz Padilla Martha Luz
Published: January 2025

This article presents a problem regarding the reading and writing process and the deficiency observed in the early education panorama in rural contexts.
We observe that children arrive at primary school with many deficiencies in the development of reading and writing and therefore many other difficulties begin here in their learning processes in general and that limit and hinder a good development of the other areas.
The proposed objective was based on the strengthening of reading and writing through playful strategies that facilitate learning in a fun way and without pressure, since observing the development of these in the classroom it was noticed that children did not respond effectively to traditional methods that were being carried out.
For this reason, we executed these processes based on three successful educational strategies which were: interactive groups, literary dialogic gatherings and the extension of learning time through which we were able to speed up and advance a lot in the development of reading, writing and communication skills.
We reinforced these processes taking into account the principles proposed in the development of these strategies such as the dialogic approach, from a perspective of equality, participation, collaborative work, strengthening the interaction of children with the surrounding community groups and the recognition of cultural identity.
The application of these strategies allowed a significant progress in overcoming the difficulties that were presented and a great motivation to exercise reading and advance in their different levels of comprehension.
Aplicación de escritorios remotos para manejo de laboratorios remotos en instituciones de educación superior
Authors: Hernández-Corona José Luis , Carmona Reyes Jonny , González Morales Cruz Norberto
Published: January 2025

En el entorno competitivo mundial, el uso de laboratorios remotos aplicados en instituciones de educación superior, permite a los estudiantes y profesores acceder y controlar equipos de laboratorio reales desde ubicaciones remotas. Esta tecnología de aplicación permite realizar pruebas con conexión de un laboratorio de una universidad a otras instituciones de educación superior, optimizando el uso de equipos costosos, permitiendo el acceso a recursos educativos para estudiantes de diversas ubicaciones geográficas y con diferentes circunstancias personales, promoviendo una educación más inclusiva. Los laboratorios remotos en la educación superior representan una innovación significativa del modo de impartir la formación práctica. Al ofrecer flexibilidad, accesibilidad y optimización de recursos, estos laboratorios pueden mejorar significativamente la experiencia de aprendizaje, para que se cumpla este propósito, los equipos de monitoreo tendrán la facultad de conexión en tiempo real, ya sea a un celular, tableta o pc, con conexión a internet. El modelo de detección de fallas mecánicas aplicando termografía o inspecciones eléctricas aplicando equipo de medición, se realizó a través de cifrado https para protección de datos en las comunicaciones. Los resultados obtenidos muestran el beneficio para los usuarios al acceder y controlar los equipos de monitoreo, para el manejo de software en tiempo real, toma de muestra, generación de reportes y el uso posterior al guardar estos en la nube.
Patient Experiences and Perspectives When MyChart is Introduced in a Large Community Hospital: Mixed Methods Study
Authors: Vanderhout Shelley , Taneja Shipra , Kalia Kamini , Wodchis Walter P , Tang Terence
Published: January 2025

Background

Patient portals, or secure websites linked to electronic medical records, have emerged as tools to provide patients with timely access to their health information. To support the potential benefits of patient portals such as improved engagement in health care, it is essential to understand how patients and caregivers experience these portals.

Objective

This study aimed to explore patient and caregiver experiences, facilitators, and barriers to accessing and using a patient portal called MyChart during the initial stages of its implementation.

Methods

We applied explanatory sequential mixed methods to conduct a web-based questionnaire and semistructured interviews with MyChart users and nonusers at a large community hospital in Ontario, Canada. Among users, we explored user satisfaction with MyChart, its impact on care, and areas for improvement. For nonusers, we explored barriers to MyChart access and willingness to use it in the future. Descriptive statistics and thematic analysis were used for data analysis.

Results

A total of 5651 patients and caregivers completed the web-based questionnaire and 18 (12 users and 6 nonusers) participated in interviews. MyChart users primarily learned about the portal through email (n=1288, 39%), after-visit summaries (n=953, 29%), and hospital staff (n=408, 12%). Nonusers cited lack of awareness (n=1291, 59%) and registration difficulties (n=707, 32%) as some barriers to activation and adoption, but the majority would consider activating and using MyChart if they could learn more about it (n=1126, 54%). Users valued MyChart for preparing for health care encounters but expressed dissatisfaction with limited features and access to medical history and test results, whereas nonusers tended to be unsure about the benefits of using MyChart, especially if they were infrequent health care users.

Conclusions

Patient portals offer benefits, but barriers to access and limited functionality can hinder widespread use. To enhance the adoption and potential benefits of patient portals, targeted outreach and comprehensive access to health information are essential to promote positive and seamlessly integrated health care experiences.