bluuebunny/crossref_metadata_2025 huggingface dataset:
УПРАВЛІНСЬКА СТРАТЕГІОЛОГІЯ: КАДРОВЕ ЗАБЕЗПЕЧЕННЯ СИСТЕМИ ПУБЛІЧНОГО АДМІНІСТРУВАННЯ В УМОВАХ ВОЄННОГО СТАНУ
Authors: Карпінський Борис , Сало Філомена
Published: October 2023

Обґрунтовано та синтезовано, що управлінська стратегіологія – це цілеспрямований системний підхід до визначення, формування та реалізації стратегічних цілей і завдань на різних управлінських рівнях з метою досягнення глобальних інтересів (місії) з вибором оптимального шляху досягнення означених пріоритетів та конкурентної переваги. Виділено, що базова сутність управлінської стратегіології особливо не відрізняється від традиційних схем стратегії розвитку (починаючи з місії, аналізу середовища й ресурсів та закінчуючи контролем), але вже на початковому етапі активно включає методологію дослідження її наповнення, виходячи з обставин, що дозволяє уникнути чи знизити ризик недоотримання віддачі на довготривалому проміжку. Доведено, що пріоритетно-мотивне значення такого підходу посилюється в умовах воєнного стану, оскільки за них різні суб’єкти управлінської діяльності мають здійснювати вибір оперативних дій за накладання надзвичайних обставин й обмежень як в плані безпеки, так і потреби досягнення програмного результату. Наголошено, що з соціальної та економічної точок зору питання регулювання ринку праці в умовах воєнного cтану в системі публічного адміністрування є одним із пріоритетних, оcкільки воно пов’язане із захиcтом прав працівника та права на працю, а з точки зору макроекономічного розвитку й положень управлінської стратегіології, наявніcть робочих міcць є запорукою розвитку економіки та поповнення бюджетів різних рівнів. Визначено особливості кадрового забезпечення органів публічного адміністрування в умовах воєнного стану.
МИТНО-СЕРВІСНІ ВІДНОСИНИ ЯК ЕЛЕМЕНТ АДМІНІСТРАТИВНО-ПРАВОВИХ ВІДНОСИН
Authors: Лютіков Павло , Макарова Світлана
Published: October 2023

Досліджено теоретичні питання формування митно-сервісних правовідносин, як елемент системи адміністративних правовідносин. В статті розглянуто основні аспекти митно-сервісних правовідносин, їх роль у забезпеченні функціонування митних органів, а також правовий режим та правові обов'язки сторін цих правовідносин. Методологічною основою дослідження є системний та діалектичний підхід до дослідження митно-сервісних правовідносин в системі адміністративного права України. У процесі вирішення зазначених завдань застосовано загально наукові та спеціальні методи наукового пізнання: методи наукової абстракції та узагальнення, аналізу і синтезу, індукції та дедукції; спостереження, порівняння, декомпозиційного аналізу – при уточненні та поглибленні категоріально-понятійного апарату сервісної функції; групування, статистичного порівняння. Митно-сервісні правовідносини є важливим елементом адміністративних правовідносин, які визначають взаємодію між митними органами та суб'єктами митного процесу. Вони відіграють ключову роль у забезпеченні ефективної роботи митних органів, дотриманні митних правил і регулюванні митного обігу товарів. Удосконалено розуміння та місця в системі правовідносин митно-сервісних правовідносин, зокрема виокремлено в окрему групу митно-сервісні правовідносини як особливу групу митних правовідносин.
ПРЕДМЕТНО-МАНІПУЛЯТИВНА ДІЯЛЬНІСТЬ ЯК ПРОВІДНА ДІЯЛЬНІСТЬ РАННЬОГО ДИТИНСТВА
Authors: Дергунова Ольга
Published: October 2023

Дана стаття зосереджена на вивченні предметно-маніпулятивної діяльності в ранньому дитинстві, що є ключовою складовою для раннього дитячого розвитку. Вирішальні етапи формування цієї діяльності протягом перших трьох років життя дитини мають значний вплив на її подальший психічний та соціальний розвиток. Дитина активно проявляє інтерес до оточуючих предметів, розвиваючи свої моторні та когнітивні навички. Стаття відзначає перехід від ознайомлювальної гри до сюжетної, вказуючи на важливість педагогічного супроводу. Аналіз робіт вчених, зокрема А. Макаренко, Т.І. Поніманська, Я. Чепіга, В. Сухомлинський, Гавриш Н.В., Рагозіна В.В., Васильєва С.А., К. Ушинський, виявив основні аспекти та особливості цієї діяльності. Важливість дослідження полягає у зрозумінні, як предметно-маніпулятивна діяльність впливає на взаємодію дитини з соціумом, її адаптаційні здібності, креативне мислення та здатність рішення проблем.
ОСОБЛИВОСТІ ЖАНРУ ТА СТИЛЮ СОНЕТНОЇ ТВОРЧОСТІ Ф. СІДНІ
Authors: Ляпічева Олена , Задунай Вероніка
Published: October 2023

У статті досліджується жанрово-стильова своєрідність сонетів Ф. Сідні у зв’язку зі зміною світогляду митців кінця епохи Відродження та поступовим набуттям ними рис маньєризму. Розкривається актуальність теми, яка не отримала достатнього рівня дослідження в українській науці. У художній практиці мистецтва манери відбувається відхід автора, який усвідомлює себе наслідувачем самого Творця, від настанови наслідувати Його творіння та пізньоренесансне відкриття множинності способів співвіднесення ідеального та реального у людському житті. У сонетному циклі Ф. Сідні «Астрофіл і Стелла» основоположними для жанрової організації сонета складниками оновлення жанру є: 1) оформлення принципів умовно-символічного зображення любовних стосунків, забезпеченого переосмисленням пасторальної ситуації самоспоглядання поета-пастуха в його свідомому усамітненні; 2) формування концепції любові як духовного саморозладу особистості; 3) відтворення опозиції «бути – здаватись» в образі коханої; 4) ствердження переваги мистецтва над природою і виявлення нездоланності природної недовершеності його засобами.
ОСОБЛИВОСТІ ПРОВЕДЕННЯ ПОДАТКОВОГО КОНТРОЛЮ В УКРАЇНІ В УМОВАХ ЦИФРОВІЗАЦІЇ
Authors: Ткачик Леся , Сеньків Данило
Published: October 2023

Спрямованість податкових реформ в Україні, розвиток партнерських взаємовідносин між платниками та контролюючими органами та посилення процесів цифровізації в економіці і суспільстві загалом вимагає нових підходів до проведення податкового контролю. Сучасний стан функціонування системи податкового контролю в Україні свідчить про необхідність та одночасно неготовність її до переходу на нові прогресивніші форми. Проведений аналіз стану податкових перевірок та динаміки податкового боргу показав, що превентивні заходи податкового контролю не дисциплінують платників щодо погашення ними податкової заборгованості, натомість кількість фактично проведених податкових перевірок позитивно впливають на погашення податкового боргу платниками. Такі результати дослідження свідчать про наявність проблем у налагодженні довірливих взаємин між платниками і контролюючими органами та необхідність пошуку шляхів їх налагодження через розвиток прогресивних форм та підходів до проведення податкового контролю в контексті посилення процесів цифровізації, зокрема активне застосування ІТ технологій для мінімізації суб’єктивного фактору.
Grice's Maxims in Moroccan EFL: A Cultural Approach through Optimality Theory
Authors: Kamal Assissou , Ben Mhamed Mohamed
Published: October 2023

The primary objective of the present study is to examine the structure of Grice's Maxims within the particular cultural setting of Morocco. The aim of this investigation is to scrutinize the impact of societal expectations and linguistic strategies on the production of conversational implicatures in the Moroccan cultural context. The present investigation employs Optimality Theory as a theoretical framework to examine a range of factors, such as power dynamics, social distance, politeness, sarcasm, and specific linguistic characteristics within the social and cultural context of Moroccan Arabic. This study argues that an understanding of the appropriate use of conversational implicatures enhances the cross-cultural competence of English as a Foreign Language (EFL) Moroccan Learners. The findings reveal the complexity of various constraints that shape the process of Moroccan conversational decision-making, unveiling noteworthy differences in comparison to the norms common to Western culture. The employment of the participant observation technique enabled a thorough investigation that was authentic and culturally sensitive, thereby enriching the understanding of conversational implicatures in a diverse global setting.
The Overview of Political Science in Contemporary Politics
Authors: Aryodiguno Harryanto
Published: October 2023

In this article, the author discusses the concepts of nations and states, power and authority. They examine the different ways in which nations and states can combine and the various forms of power and influence that can be exerted. The author also touches on how power can be used to shape preferences and control the climate of opinion. The article concludes by noting that awareness of the different forms of power and how they are exercised is important in understanding the dynamics of political systems.
Introduire l’ordinateur à l’école. Les clés de la réussite
Authors: Fantoli Christian
Published: October 2023

Comment intégrer en classe un dispositif « un élève / un appareil numérique » ? Quelles sont les conditions pour que les enseignants exploitent réellement et à long terme l’équipement individuel des élèves ? Que faut-il prendre en compte pour favoriser les apprentissages dans un tel contexte ? Qu’est-ce que le principe de Quiétude numérique ? Comment favoriser l’engagement des collaborateurs ? L’appareil doit-il être personnel ou propriété de l’établissement ? Quelles sont les précautions à prendre en termes de santé et d’écologie ? Ce livre s’adresse à : • tout responsable réfléchissant à la mise en place d’un dispositif « un élève/ un appareil numérique » en milieu scolaire, pour des élèves âgés de 5 à 15 ans ; il permet d’aborder les questions de rigueur avant de se lancer dans un tel projet et apporte les éclairages nécessaires en termes de gouvernance ; • tout chef de projet en charge de mettre en place un tel dispositif en proposant d’indispensables ressources d’ingénierie pédagogique ; • tout formateur devant accompagner des enseignants amenés à travailler avec des élèves équipés individuellement d’un appareil numérique ; il présente des méthodes incluant les facteurs ayant le plus d’impact sur les apprentissages.
EKSPLOITASI SEKSUAL KOMERSIAL ANAK PADA KELUARGA KURANG MAMPU DI KOTA MOJOKERTO
Authors: Kandar's Family Zidan Ilmi Mubarok
Published: October 2023

Eksploitasil seksuall komersiall anak merupakanl  suatu  lusaha  yang  dilakukan  oleh  lseseorang untuk lmemanfaatkan dan lmemeras ltenaga lkerja lanak demi lkepentingan bersama lmaupun lpribadi. lBagi lkeluarga lmiskin, lanak pada lumumnya  lmemiliki lfungsi ekonomis, dan lmenjadi salah  satu  lsumber  lpendapatan  atau  lpenghasilan  lkeluarga,  sehinggal anak  menjadi terbiasal sejak usia dini lterlatih lmenghasilkan uang luntuk membantu lekonomi lkeluarganya. lPemanfaatan atau lpemerasan lpekerja lanak sangat  beragam,  mulai  dari  lanak-anak  yang  ldijadikan lpemuas nafsu lorang yang lmampu membayar lmahal. Dalam  lkeadaan ekonomi yang  lmemberatkan  seperti  ini  lmembuat orang ltua atau lkeluarga dari ltingkat lekonomi lmenengah ke lbawah llebih memilih menjadikanl anak-anakl mereka sebagai lpenopang lekonomi lkeluarga dari pada lbersekolah.
PELATIHAN DESIGN UI/UX DALAM MEMBANGUN WEBSITE PADA RW.013 CIPINANG MELAYU JAKARTA TIMUR
Authors: Prahartiwi Lusa Indah , Dari Wulan , Pujiastuti Endang , Yuningsih Yuyun
Published: October 2023

Rukun Warga is a community institution that was formed through deliberation of neighborhood association administrators in order to provide government services to the community that are recognized by the local government. However, along with the rapid development of information, the services provided by RW administrators. 013 Cipinang Melayu is still not optimal because it still uses a manual system. There is no information system to find out any information available in the RW area. 013 Cipinang Melayu is one of the obstacles in the field. Therefore, it is hoped that this web-based information system can reduce the risks faced by manual systems so that the services provided can be more effective and efficient. The results of this community service activity are in the form of a website-based community information system. By determining an attractive user interface/appearance of a website and the UX designer is tasked with determining how the website operates so as to produce an information system with a user interface that is effective for use. With this information system, it is hoped that it will make it easier for RW administrators and the public to collect data or obtain information.
Epidemiological cut-off values for non-O1/ non-O139 Vibrio cholerae disc diffusion data generated by standardised methods
Authors: Smith P , Le Devendec L , Jouy E , Larvor E , Lesne J , Kirschner AKT , Rehm C , Leopold M , Pleininger S , Heger F , Jäckel C , Göllner C , Nekat J , Hammerl JA , Baron S
Published: October 2023

This work generates the data needed to set epidemiological cut-off values for disc-diffusion zone measurements of Vibrio cholerae. The susceptibility of 147 European isolates of non-O1/non-O139 V. cholerae to 19 antibiotics was established using a standardised disc diffusion method which specified incubation of Mueller Hinton agar plates at 35°C. Epidemiological cut-off values were calculated by analysis of the zone size data with the statistically based normalised resistance interpretation method. Cut-off values for 17 agents were calculated by analysis of the aggregated data from all 4 laboratories participating in this study. The cut-off values calculated were ≥18 mm for amoxicillin/clavulanate, ≥18 mm for amikacin, ≥19 mm for ampicillin, ≥27 mm for cefepime, ≥31 mm for cefotaxime, ≥24 mm for ceftazidime, ≥24 mm for chloramphenicol, ≥31 mm for ciprofloxacin, ≥16 mm for erythromycin, ≥ 27 mm for florfenicol, ≥16 mm for gentamicin, ≥23 mm for imipenem, ≥25 mm for meropenem, ≥29 mm for nalidixic acid, ≥28 mm for norfloxacin, ≥13 mm for streptomycin and ≥23 mm for tetracycline. For the other 2 agents the data from 1 laboratory was excluded from the censored aggregation because the data from that laboratory was considered excessively imprecise. The cut-off values for these 2 agents calculated for the aggregation of the data from 3 laboratories were ≥23 mm for trimethoprim and ≥24 mm for trimethoprim/sulfamethoxazole. These zone size data will be submitted to the Clinical Laboratory Standards Institute (CLSI) and European Committee for Antimicrobial Susceptibility Testing (EUCAST) for their consideration in setting international consensus epidemiological cut-off values for non O1/non-O139 V. cholerae.
Measurement of Electrophoretic Mobility Fluctuations of Single Particles Trapped by Optical Tweezers
Authors:   , Yeroshenko Bohdan
Published: October 2023

In this study, we focus on electrophoresis, a phenomenon that describes the movement of particles in a liquid when an external electric field is present. This movement is caused by the Coulomb force on the surface charge of the particles. Most particles develop a surface charge in water. This charge will attract or repel ions in the liquid, creating a charge shielding area known as the Electric Double Layer. Electrophoresis is inherently a surface phenomenon, closely related to the Electric Double Layer. When an external field is applied, it induces force on both the ions and the particle. This interaction results in electrophoretic drift. The speed of this drift depends on the zeta potential at the slip plane.

In this project, we use optical tweezers to investigate fluctuations in the electrophoretic movement of individual colloidal particles. Optical tweezers can hold particles from tens of nanometers to tens of microns within a tightly focused laser beam. We use a 1064 nm continuous wave laser to capture and study individual particles. The measurement is carried out by a quadrant photodiode (QPD). Since these particles undergo Brownian motion, we use this behavior for system calibration, correlating the movement of the particle with the displacement of the laser beam. A lock-in amplifier processes the signals from the QPD. By measuring the in-phase and out-of-phase noise of the QPD signal, we can separate the Brownian motion and fluctuations in electrophoretic drift.

We propose that the in-phase component is composed of a mix of two signals: one from fluctuations in electrophoretic drift and the other from Brownian motion. This observation forms the cornerstone of our methodology. We performed simulations based on the Langevin equation to model fluctuating mobility. These simulations confirmed that the fluctuating term only affects the in-phase component of the lock-in amplifier signal. Therefore, our method can accurately distinguish fluctuations in electrophoretic mobility. A significant observation is the presence of large, slow, and non-Gaussian fluctuations. Given these fluctuations and the known relationship between charge and electrophoretic mobility, we hypothesize that the difference between zeta potential and diffuse layer potential can be explained by the Jensen inequality.

Using Power Spectral Density (PSD) analysis, we estimate the autocorrelation function of the mobility fluctuations. The resulting autocorrelation function shows much larger time constants than initially expected. The possible link between these fluctuations and surface charge dynamics is an intriguing path for further research. If demonstrated, it would deepen our understanding of colloidal dynamics. This knowledge is crucial in sectors like pharmaceuticals, food processing, and materials science.
Efficiency Assessment of 15 Nebuliser Systems by the Respirable Drug Delivery Rate: A Comparable Quality Parameter
Authors: Humphry Nicola
Published: October 2023

Nebuliser therapy is a relevant therapy option for respiratory diseases, yet studies have demonstrated a wide variation in nebuliser drug delivery efficiency. This study assessed the aerosol performance of 15 commercially available nebuliser systems based on a European standard, and calculated the respirable drug delivery rate (RDDR) as an objective, clinically important measure of efficiency. Findings confirmed that the efficiency of nebuliser systems differs significantly, which could potentially impact the therapeutic success of the drug delivered. The authors of the study recommend that physicians select a device with a high RDDR to ensure that patients receive clinically effective doses in a short time and thus achieve the best possible treatment effect.
The Epic of Genesis: Catherine Malabou and the gêne of Epigenetics
Authors: Basile Jonathan
Published: October 2023

This article examines the conflicting representations of plasticity and epigenetics in the work of philosopher Catherine Malabou and evolutionary theorists Mary Jane West-Eberhard and Eva Jablonka. In order to speak of a new biological ‘paradigm’ and to attribute values of novelty or inventiveness to life itself, Malabou has to suppress the unsettled debates within the life sciences. The aporias of evolutionary narrative and causality reveal a necessary differentiality and textuality that belongs neither to life nor science itself, but leaves a haunting remanence within every corpus. New materialism resists this necessity of life-science, which calls for a deconstructive reading.
Life, Would That it Might Be To Say – Power, Metaphor, Tragen, Épuis(s)ement
Authors: Waltham-Smith Naomi
Published: October 2023

In Insister – À Jacques Derrida Cixous declares that she will have to write ‘the book of words’, among which ‘words of power’ will be vermögen (to be able), together with Unvermöglickeit (impossibility), and tragen (to carry), along with austragen (to bear to term) and übertragen (to transfer, translate, also in the sense of metaphor). By examining Derrida's reading of Cixous in H. C. pour la vie, c'est à dire … this article deepens the association of tragen with life and power that fascinates Derrida in the second year of his final seminar where he tracks a thread between Austrag, Walten, Trieb, and Vermögen. Its point of departure is a passage towards the end of H. C. pour la vie where Derrida speaks of the trap of metalanguage or, rather, metaphrasis that lurks in the c’est of c'est à dire. I link this passage both to the discussion of metaphorization in the earlier ‘Le puits et la pyramide’ and the characterization of puisse as ‘the exhaustion [ l'épuisement] of the sun before its time’ in the essay on Cixous to associate puissance with the wearing-out of the world and its usure in the double sense elaborated in ‘La mythologie blanche’.
Clinical manifestation of neuroendocrine tumor – carcinoid heart disease
Authors: Akildzhonov F. R. , Buziashvili Yu. I. , Asymbekova E. U. , Artamonova E. V. , Tugeeva E. F. , Akhmedov D. R. , Basanets A. V.
Published: October 2023

Carcinoid heart disease (CHD) is a rare manifestation of the carcinoid syndrome, but eventually occurs in most patients and is a major cause of cardiovascular mortality. The development of CHD is known to be a negative prognostic factor in patients with advanced neuroendocrine tumors. The mechanism of CHD pathophysiology remains poorly understood. Progress in early diagnosis and improvement of therapeutic approaches over the last decade has reduced hospital mortality in this cohort of patients. In this clinical case we summarize clinical features of the examination, treatment of and demonstrate modern pathogenetic aspects of the development of this condition.
Cytoreductive surgery in patients with advanced ovarian cancer: Surgical complexity score and postoperative complications
Authors: Yakovleva M. G. , Gorodnova T. V. , Kotiv Kh. B. , Smirnova O. A. , Lavrinovich O. E. , Mikaya N. A. , Trifanov Yu. N. , Guseynov K. D. , Bakhidze E. V. , Meshkova I. E. , Nekrasova E. А. , Shagal М. А. , Тyatkov S. А. , Okonechnikova D. V. , Ulrich E. A. , Urmancheeva A. F. , Rostovcev D. M. , Berlev I. V.
Published: October 2023

Introduction. Cytoreductive surgery in patients with advanced ovarian cancer often involves extensive combined surgical interventions, which can affect the development of postoperative complications.

Aim. To evaluate the results of surgical treatment in patients with advanced ovarian cancer.

Methods. The study included 190 primary IIB–IV stage ovarian cancer patients who underwent surgical treatment in the oncogynecological department of the National Medical Research Centre of Oncology n. a. N. N. Petrov (Saint Petersburg, Russia) from August 2017 to August 2020. The dissemination in the peritoneum was assessed by calculating the peritoneal carcinomatosis index (PCI). Surgical complexity score was assessed using Aletti’s classification. Analysis of postoperative complications was carried out in accordance with the Clavien – Dindo classification.

Results. The incidence of postoperative complications depended on the index of surgical complexity score (5 % – with a low index, 15 % – with median, 63 % – with a high one, p < 0.0010). In the group of primary cytoreductive surgeries, cases of median (48.9 %) and high complexity score (24.44 %) prevailed; in the group of interval debulking surgery, cases of low (52.4 %) and median (36.5 %) complexity score prevailed. The index of surgical complexity score depended on the peritoneal carcinomatosis index (PCI). The operation time, the volume of blood loss, the duration of hospitalization, frequency of bowel resection depended on the peritoneal carcinomatosis index and the surgical complexity score (p < 0.0001).

Conclusions. The level of surgical complexity score in patients with advanced ovarian cancer depends on the peritoneal carcinomatosis index. The level of surgical complexity score is higher in the group of primary debulking surgery, which effect on frequency of postoperative complications.
Functioning of state banks in Ukraine in the conditions of war risks
Authors:   SESE “The Academy of Financial Management”, KLYMENKO Kateryna , UKHNAL Nataliia ,   SESE “The Academy of Financial Management”, STOLYAROV Vasyl ,   SESE “The Academy of Financial Management”, SLIUSARENKO Ievgen ,   SESE “The Academy of Financial Management”
Published: October 2023

The banking sector plays a pivotal role in any country’s economic stability and growth, and Ukraine is no exception. In recent years, the banking sector in Ukraine has faced unprecedented challenges stemming from both internal and external factors, with military risks looming large on the horizon. This paper delves into the inherent nature of the development and operation of state banks in Ukraine, focusing on their resilience and adaptability in the face of such military risks. The paper explores the unique challenges that state banks encounter during times of military risks, including increased exposure to non-performing loans (NPLs). It assesses the implications of NPLs on the financial stability of state banks and the broader banking sector, highlighting the need for effective management strategies. Special focus is directed towards the examination of banking security metrics, which experienced substantial impacts due to military disruptions in 2014 and 2022, as well as the pandemic shock of 2020. Furthermore, this study analyzes the measures taken by state banks and the Ukrainian government to mitigate the impact of military risks on the banking sector. It discusses the role of international financial institutions and regulatory bodies in supporting state banks and fostering financial stability. Additionally, the paper explores the potential for innovation and technological advancement to enhance the resilience of state banks in Ukraine. It examines how digitalization and fintech solutions can contribute to more efficient operations and risk mitigation. In conclusion, this comprehensive analysis sheds light on the inherent nature of development and operation of state banks in Ukraine in the presence of military risks. It underscores the importance of robust risk management strategies, international cooperation, and technological innovation in ensuring the continued stability and functionality of state banks in these challenging circumstances. This research not only contributes to the academic understanding of state banks in wartime but also offers practical insights for policymakers and stakeholders in the Ukrainian banking sector.
Management of innovative development of construction enterprises: realities and prospects
Authors:   European University, TSYBA Oleksandr
Published: October 2023

The article examines the role of innovative development in ensuring the effective functioning and development of domestic enterprises in the construction industry in modern conditions. The key factors affecting the success of the implementation of innovations in construction enterprises are systematized and the principles of managing their innovative development are defined. Features and challenges faced by construction enterprises in the field of innovative development in the conditions of martial law in Ukraine are outlined. The main trends in the management of innovative development of construction enterprises were analyzed, which currently include: green construction and carbon-free production as elements of a circular (closed loop) economy; 3D printing technology in construction; digitization of processes/services, use of augmented reality technology; predictive analysis involving artificial intelligence technologies; mobile access technologies and integration of disparate data in processes; robotization of certain works and use of drones; development of the “smart cities” concept. Recommendations and proposals for improving the management of innovative development of construction enterprises to achieve sustainable growth and competitiveness in this field have been developed. The strategy of innovative development of construction enterprises is proposed. The strategy of managing the innovative development of construction enterprises may include the following steps and stages: analysis of the needs and capabilities of enterprises; definition of strategic goals; resource planning; research and development of new technologies, products or services that can be implemented in the enterprise of the construction industry; financing of innovative projects; implementation and commercialization of innovations in practice; monitoring and evaluation of the effectiveness of implemented innovations; ensure establishment of an innovative culture at the enterprise; development of partnership relations with other enterprises; attraction of customers and clients; provision of training and dissemination of knowledge about innovations among the company's employees; establishment of cooperation with state bodies, institutions.
Glycoprotein non-metastatic melanoma protein B expression correlates with the prognosis of acute liver injury/failure
Authors: Kumagai Kotaro , Kanmura Shuji , Mawatari Seiichi , Nakamura Yuko , Eguchi Hiromi , Taniyama Oki , Toyodome Ai , Ijuin Sho , Sakae Haruka , Tabu Kazuaki , Oda Kohei , Shimata Keita , Hibi Taizo , Ido Akio
Published: October 2023

Background: Glycoprotein non-metastatic melanoma protein B (GPNMB) is expressed in macrophages during recovery from acute liver injury (ALI) in carbon tetrachloride (CCl4)-induced liver injury model mice. In this retrospective study, we assessed whether GPNMB levels in the serum and injured liver correlate with liver injury severity and prognosis in patients with ALI or acute liver failure (ALF).

Methods: The study involved 56 patients with ALI or ALF who visited the Kagoshima University Hospital. Serum GPNMB level was measured over time, and the localization, proportion, origin, and phenotype of GPNMB-expressing cells in the injured liver were assessed. Finally, the phenotypes of human monocyte-derived macrophages and peripheral blood mononuclear cells (PBMCs) of patients with ALI and ALF were analyzed.

Results: Peak GPNMB levels were significantly higher in patients with ALF and hepatic encephalopathy (HE), as well as in those who underwent liver transplantation or died, than in others. The peak GPNMB level correlated with prothrombin activity, prothrombin time-international normalized ratio, Model for End-stage Liver Disease score, and serum hepatocyte growth factor level. GPNMB was expressed in CD68-positive macrophages, and its level increased with the severity of liver injury. The macrophages showed the same polarization as M2c macrophages induced with interleukin-10 from human monocytes. Moreover, PBMCs from patients with ALF exhibited an immunosuppressive phenotype.

Conclusion: We found that GPNMB levels in the serum and injured liver, which increased in patients with ALF, especially in those with HE, correlated with the severity of liver injury and prognosis of ALI and ALF. Moreover, GPNMB-positive macrophages exhibited the M2c phenotype. Our results indicate that persistently high GPNMB levels may be a prognostic marker in patients with ALI and ALF.
Current progress of ferroptosis in cardiovascular diseases
Authors: Zhang Jie , Guo Caixia
Published: October 2023

Ferroptosis, a newly recognized form of nonapoptotic regulated cell death, is characterized by iron-dependent lipid peroxidation. Biological processes, such as iron metabolism, lipid peroxidation, and amino acid metabolism, are involved in the process of ferroptosis. However, the related molecular mechanism of ferroptosis has not yet been completely clarified, and specific and sensitive biomarkers for ferroptosis need to be explored. Recently, studies have revealed that ferroptosis probably causes or exacerbates the progress of cardiovascular diseases, and could be the potential therapeutic target for cardiovascular diseases. In this review, we summarize the molecular mechanisms regulating ferroptosis, inducers or inhibitors of ferroptosis, and the current progresses of ferroptosis in cardiovascular diseases. Furthermore, we discuss the emerging challenges and future perspectives, which may provide novel insights into the treatment of cardiovascular diseases.
Intersectionality of disability and cultural/linguistic diversity in the UK: a literature review
Authors: Kaplan Gamze , Celik Pinar
Published: October 2023

This article explores the intersectionality of cultural and linguistic diversity and having a child with a disability, highlighting the unique challenges faced by parents from a minority ethnic background at this intersection. With increasing globalization, diverse and multicultural populations have become more prevalent, necessitating inclusive systems that address the unique needs of minority ethnic groups. Understanding the experiences of parents at the intersection of cultural and linguistic diversity and having a child with a disability is crucial for providing equitable access to education and support. This paper provides an overview of studies conducted in the UK, focusing on the challenges faced by culturally and linguistically diverse families from a minority ethnic background with children with disabilities and emphasizing factors such as religion, cultural beliefs, language barriers, and unique insights into specific populations. The findings emphasize the need for a comprehensive understanding of the intersectionality of cultural and linguistic diversity and disability to create inclusive educational environments that empower all children, irrespective of their cultural background or abilities.
Open access-enabled evaluation of epigenetic age acceleration in colorectal cancer and development of a classifier with diagnostic potential
Authors: Widayati Tyas Arum , Schneider Jadesada , Panteleeva Kseniia , Chernysheva Elizabeth , Hrbkova Natalie , Beck Stephan , Voloshin Vitaly , Chervova Olga
Published: October 2023

Aberrant DNA methylation (DNAm) is known to be associated with the aetiology of cancer, including colorectal cancer (CRC). In the past, the availability of open access data has been the main driver of innovative method development and research training. However, this is increasingly being eroded by the move to controlled access, particularly of medical data, including cancer DNAm data. To rejuvenate this valuable tradition, we leveraged DNAm data from 1,845 samples (535 CRC tumours, 522 normal colon tissues adjacent to tumours, 72 colorectal adenomas, and 716 normal colon tissues from healthy individuals) from 14 open access studies deposited in NCBI GEO and ArrayExpress. We calculated each sample’s epigenetic age (EA) using eleven epigenetic clock models and derived the corresponding epigenetic age acceleration (EAA). For EA, we observed that most first- and second-generation epigenetic clocks reflect the chronological age in normal tissues adjacent to tumours and healthy individuals [e.g., Horvath (r = 0.77 and 0.79), Zhang elastic net (EN) (r = 0.70 and 0.73)] unlike the epigenetic mitotic clocks (EpiTOC, HypoClock, MiAge) (r < 0.3). For EAA, we used PhenoAge, Wu, and the above mitotic clocks and found them to have distinct distributions in different tissue types, particularly between normal colon tissues adjacent to tumours and cancerous tumours, as well as between normal colon tissues adjacent to tumours and normal colon tissue from healthy individuals. Finally, we harnessed these associations to develop a classifier using elastic net regression (with lasso and ridge regularisations) that predicts CRC diagnosis based on a patient’s sex and EAAs calculated from histologically normal controls (i.e., normal colon tissues adjacent to tumours and normal colon tissue from healthy individuals). The classifier demonstrated good diagnostic potential with ROC-AUC = 0.886, which suggests that an EAA-based classifier trained on relevant data could become a tool to support diagnostic/prognostic decisions in CRC for clinical professionals. Our study also reemphasises the importance of open access clinical data for method development and training of young scientists. Obtaining the required approvals for controlled access data would not have been possible in the timeframe of this study.
A wide-beam NCS algorithm for multi-receiver SAS based on azimuth spectrum superposition
Authors: Ning Mingqiang , Zhong Heping , Li Han , Ma Mengbo , Dai Lili , Tang Jinsong
Published: October 2023

The existing multi-receiver synthetic aperture sonar (SAS) imaging algorithms are suitable for narrow-beam width, which will lead to a decrease in imaging quality under wide-beam condition and are not in line with the development needs of SAS. We propose a non-linear chirp scaling algorithm (NCSA) for wide beam multi-receiver SAS. Firstly, the point target reference spectrum (PTRS) of each receiver is obtained by the Lagrange inversion theorem (LIT), and then the under-sampled signal in the azimuth frequency domain is obtained through azimuth spectrum extension; Then, considering the cubic term of range frequency in the PTRS and the linear variation of equivalent frequency modulation slope with range, each receiver is imaged using the NCSA, and coherent superposition is performed in the azimuth frequency domain to eliminate spectrum aliasing caused by azimuth spectrum extension; Finally, the azimuth inverse transform is performed on the superimposed signal to obtain the focusing imaging. Computer simulation experiments and field data verify that this method is superior to the existing SAS imaging algorithm, improving the quality of wide-beam imaging, avoiding the interpolation operation of the traditional range-Doppler algorithm, and saving computation cost.
Effectiveness of outpatient parenteral antimicrobial therapy (OPAT) for patients with cranial infection
Authors: Kilinc Fatma , Setzer Matthias , Behmanesh Bedjan , Jussen Daniel , Gessler Florian , Bayerl Simon , Kempf Volkhard A. J. , Kessel Johanna , Czabanka Marcus , Prinz Vincent
Published: October 2023

Objective

Outpatient parenteral antimicrobial therapy (OPAT) is a well-established and cost-effective method for improving the efficient use of healthcare resources. However, only a few centres in Germany perform it. Here we analysed OPAT for the treatment of patients with cranial infections in our neurosurgical department.

Methods

This retrospective study analysed patients with cranial infections and the need for intravenous (i.v.) antimicrobial treatment between 2018 and 2021.

All diagnosed intracranial infections were defined into two infection categories such as long-term antimicrobial treatment and short-term antimicrobial treatment. All included patients were discharged with a peripherally inserted central catheter (PICC) line. Prior to discharge, all patients received training in the safe administration of their medications via the PICC line. The duration of OPAT and the rate of readmission after OPAT were analysed.

Results

We identified a total of 45 patients treated with OPAT for cranial infections. Intradural involvement was present in 40 cases (88.9%). The average length of hospital stay for this cohort after surgical treatment was 45 ± 15 days. 5 patients were treated for soft tissue/skin infection. Surgery was not required in this cohort. The mean hospital stay for this cohort was 8 ± 6 days. Gram-positive organisms were isolated in most cases (53.3%). The most common pathogens were Staphylococcus aureus followed by other Staphylococcus species. For all included patients, OPAT was performed after discharge for an average of 43.1 ± 14 days. There were five cases of readmission due to treatment failure. No serious adverse events or complications of OPAT were observed.

Conclusion

OPAT enables better patient-centred healthcare close to home. The length of hospital stay can be reduced and adverse events due to prolonged hospitalisation can be avoided.
End to end stroke triage using cerebrovascular morphology and machine learning
Authors: Deshpande Aditi , Elliott Jordan , Jiang Bin , Tahsili-Fahadan Pouya , Kidwell Chelsea , Wintermark Max , Laksari Kaveh
Published: October 2023

Background

Rapid and accurate triage of acute ischemic stroke (AIS) is essential for early revascularization and improved patient outcomes. Response to acute reperfusion therapies varies significantly based on patient-specific cerebrovascular anatomy that governs cerebral blood flow. We present an end-to-end machine learning approach for automatic stroke triage.

Methods

Employing a validated convolutional neural network (CNN) segmentation model for image processing, we extract each patient’s cerebrovasculature and its morphological features from baseline non-invasive angiography scans. These features are used to detect occlusion’s presence and the site automatically, and for the first time, to estimate collateral circulation without manual intervention. We then use the extracted cerebrovascular features along with commonly used clinical and imaging parameters to predict the 90 days functional outcome for each patient.

Results

The CNN model achieved a segmentation accuracy of 94% based on the Dice similarity coefficient (DSC). The automatic stroke detection algorithm had a sensitivity and specificity of 92% and 94%, respectively. The models for occlusion site detection and automatic collateral grading reached 96% and 87.2% accuracy, respectively. Incorporating the automatically extracted cerebrovascular features significantly improved the 90 days outcome prediction accuracy from 0.63 to 0.83.

Conclusion

The fast, automatic, and comprehensive model presented here can improve stroke diagnosis, aid collateral assessment, and enhance prognostication for treatment decisions, using cerebrovascular morphology.
Unilateral optogenetic kindling of hippocampus leads to more severe impairments of the inhibitory signaling in the contralateral hippocampus
Authors: Tescarollo Fabio Cesar , Valdivia Daniel , Chen Spencer , Sun Hai
Published: October 2023

The kindling model has been used extensively by researchers to study the neurobiology of temporal lobe epilepsy (TLE) due to its capacity to induce intensification of seizures by the progressive recruitment of additional neuronal clusters into epileptogenic networks. We applied repetitive focal optogenetic activation of putative excitatory neurons in the dorsal CA1 area of the hippocampus of mice to investigate the role of inhibitory signaling during this process. This experimental protocol resulted in a kindling phenotype that was maintained for 2 weeks after the animals were fully kindled. As a result of the different phases of optogenetic kindling (OpK), key inhibitory signaling elements, such as KCC2 and NKCC1, exhibited distinct temporal and spatial dynamics of regulation. These alterations in protein expression were related to the distinct pattern of ictal activity propagation through the different hippocampal sublayers. Our results suggest the KCC2 disruption in the contralateral hippocampus of fully kindled animals progressively facilitated the creation of pathological pathways for seizure propagation through the hippocampal network. Upon completion of kindling, we observed animals that were restimulated after a rest period of 14-day showed, besides a persistent KCC2 downregulation, an NKCC1 upregulation in the bilateral dentate gyrus and hippocampus-wide loss of parvalbumin-positive interneurons. These alterations observed in the chronic phase of OpK suggest that the hippocampus of rekindled animals continued to undergo self-modifications during the rest period. The changes resulting from this period suggest the possibility of the development of a mirror focus on the hippocampus contralateral to the site of optical stimulations. Our results offer perspectives for preventing the recruitment and conversion of healthy neuronal networks into epileptogenic ones among patients with epilepsy.
Differences in seed characteristics, germination and seedling growth of Suaeda salsa grown in intertidal zone and on saline inland
Authors: Wang Qikang , Xu Deliang , Yin Benfeng , Zheng Yueling , Guo Xiaohong , Li Yating , Sun Xiyan , Wang Lei , Wu Nan
Published: October 2023

The ecological restoration of saline land in the Yellow River Delta is essential for the sustainability of this region. Halophytic species, like Suaeda salsa, are critical for the restoration process. However, potential differences in traits of heteromorphic seeds collected from the intertidal zone and inland condition have been largely overlooked. The seeds were analyzed for hardness, nutrient elements, and secretions, while structural differences were observed under a stereomicroscope. Germination percentages of the different seed types and subsequent seedling growth were also recorded. Our study found that the black seeds from intertidal zone had the highest hardness when compared to the three other types of seeds. Nutrient analysis revealed that brown seeds had a higher iron (Fe) content than black seeds. Accordingly, brown seed embryos were greener compared to their black seed counterparts due to the iron’s role in chlorophyll synthesis. Our results also revealed that brown seeds secreted greater amounts of exudates than black seeds. Finally, both the intertidal brown seeds and the inland-grown brown seeds had higher germination percentages and better early seedling growth than the corresponding black seeds. The differential characteristics between dimorphic seeds and seedlings may influence their environmental adaptation in different saline environments.
Bioinformatic analysis of wheat defensin gene family and function verification of candidate genes
Authors: Dong Ye , Wang Youning , Tang Mingshuang , Chen Wang , Chai Yi , Wang Wenli
Published: October 2023

Plant defensins are widely distributed in the leaves, fruits, roots, stems, seeds, and tubers. Research shows that defensin in plants play a significant role in physiological metabolism, growth and development. Plant defensins can kill and suppress a variety of pathogenic bacteria. In this study, we understand the phylogenetic relationships, protein characterization, chromosomal localization, promoter and gene structural features of the TaPDFs family through sequence alignment and conserved protein structural domain analysis. A total of 73 PDF gene members in wheat, 15 PDF genes in maize, and 11 PDF genes in rice were identified. A total of 35, 65, and 34 PDF gene members were identified in the genomes of Ae. tauschii, T. urartu, and T. dicoccoides, respectively. TaPDF4.9 and TaPDF2.15 were constructed into pART27 vector with YFP by homologous recombination for subcellular localization analysis. Subcellular localization results showed that TaPDF4.9 and TaPDF2.15 were basically located in the cell membrane and cytoplasm, and TaPDF4.9 was also located in the nucleus. TaPDF4.9 and TaPDF2.15 could inhibit the infection of Phytophthora infestans strain ‘88069’. The results suggest that TaPDFs may be able to improve disease resistance. The study of wheat defensins will be beneficial for improving wheat yield and provides a theoretical basis for research on resistance to wheat diseases.