bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation study of FGF23/D-serine in maintenance hemodialysis patients with combined hearing impairment
Authors: Yuan Dunlu , Li Jiaqing , Guo Min , Yang Qing , Huang Jingjing , Nie Jingwen , Li Ruomei , Li Qing
Published: January 2023

Background

Recent studies have reported an association between chronic renal failure and hearing impairment. Yet, the exact mechanism of action is still not fully understood. In this study, we investigated the expression of fibroblast growth factor 23 (FGF23) and D-serine in maintenance hemodialysis (MHD) patients with end-stage renal disease (ESRD) complicated with hearing impairment and further investigated the correlation between FGF23/D-serine and hearing impairment.

Methods

A total of 90 subjects, including 30 MHD patients complicated with hearing impairment, 30 MHD patients with normal hearing, and 30 controls, were included in this case-control study. Relevant data were obtained by questionnaire survey, audiometric test, enzyme-linked immunosorbent assay (ELISA) to determine FGF23 level, and high-performance liquid chromatography to determine D-serine level.

Results

MHD patients showed abnormally high expression of FGF23 and D-serine, where FGF23 and D-serine levels were significantly higher in the group with hearing impairment than in the group with normal hearing and normal controls (all P<0.01). Also, elevated FGF23 and D-serine were identified as risk factors for hearing impairment in ESRD, with ORs of 16.54 (95%CI, 2.75–99.55) and 15.22 (95%CI, 2.59–89.51), respectively. Further Person correlation analysis showed a moderate positive correlation between FGF23 and D-serine (r = 0.683, P<0.001).

Conclusion

This study provides potential biomarkers for the early detection of hearing impairment complicated by chronic renal failure, and the reduction of FGF23/D-serine may provide a potential target for the treatment of hearing impairment complicated by chronic renal failure.
Related adjustment of firm production after demand shocks
Authors: Kiss Károly Miklós , Lőrincz László , Csáfordi Zsolt , Lengyel Balázs
Published: January 2023

Multiproduct firms often diversify into technologically related activities to exploit efficiencies of joint production; however, unrelated products in the company’s portfolio provide access to distinct markets and can help to avoid industry-specific shocks. Yet, the underlying mechanisms of related and unrelated diversification are still poorly understood. Here we investigate diversification decisions of firms in periods when corporations’ markets are hit by a demand shocks. In these times, cost efficiency considerations might drive firms to reduce costs by narrowing product portfolios and focusing on combinations of technologically related products, in which economies of scope and mutual capabilities can be exploited. To test this hypothesis, we consider two measures of demand shocks, decreasing sales volumes on the product market and increasing import competition; and analyze their association with changes of product portfolios of Hungarian firms in the 2003-2012 period. We find that production has become more coherent in terms of technological relatedness after firms were exposed to demand shocks. Evidence suggests related adjustment of firm production after demand shocks such that products unrelated to firms’ core product are dropped from the portfolio but related products are added.
The ‘roaring’ twenties and African wildlife in fashionable dress: Part 1: Zebra fur patterns and femininity
Authors: Hannel Susan L.
Published: January 2023

The fur and fur patterns of African animals were part of the fashion industry’s exoticization of Africa during the 1920s. Avant-garde interest in African sculpture, African textiles and African jewellery blended with the popularity of jazz music played by African Americans to create a market for fashionable clothing inspired by Africa. Using fur from African animals, and textile prints and embroideries imitating fur patterns, reflected the most consistent interest in Africa. African safaris, world fairs and colonial expositions displaying African animals contributed to African exoticism. Books for children, textile designs illustrating African elephants and examples of fabric dyed colours called ‘lioness’ were some of the resulting consumer products. The graphic fur patterns of leopards, giraffes and zebras perfectly suited the bold geometric aesthetics of the Arts Modernes design style, while the fringe-like quality of monkey fur met the trend requirements for fringed evening wear. Zebra fur and patterns played a feminizing role in mediating the increasingly masculine dress and activities for women. The graphic black-and-white stripes linked the wearer to the exotics and adventure of Africa, while also reflecting contemporary design aesthetics and the hard-edged, chaotic American city. Because the zebra stripe originates on the fur of a peaceful prey animal, the pattern was perceived as graceful and feminine. For the modern women who wanted to participate in the adventures of the era, wearing zebra stripes tempered the interpretation of her wild life in the American urban jungle without compromising her femininity.
The Tongue as a Gateway to Voice, Resonance, Style, and Intelligibility, Angelika Nair (2021)
Authors: Terwilliger Kristina
Published: January 2023

Review of: The Tongue as a Gateway to Voice, Resonance, Style, and Intelligibility, Angelika Nair (2021)

San Diego, CA: Plural Publishing Inc., 278 pp.,

ISBN 978-1-63550-363-0, p/bk, $79.95
Economic and energetic assessment of industrial-scale solar thermal
energy in the Visegrad Region
Authors: Ghabour Rajab , Korzenszky Peter
Published: January 2023

The Visegrád group's energy security is attributed to the national
energy potential of each country. The energy potential results from the
lack of crude oil and natural gas resources, limited access to the
transmission network, and limited fuel storage. This bloc relies on raw
material supplies from Russia, which is not evenly applied to all group
members. Poland and Hungary have good storing potential, but it is not
enough to achieve energy security and independence. Russia aims to keep
control of this market while group members try diversifying their supplies
to increase energy security. The purpose of this article is to present the
energy balance in the Visegrád region. The analysis is based on the status
of the renewable energy targets in the production, demand, import and
export. Also, to determine the stability degree of these energy parameters.
The material source is the literature and the energetic data from the
European statistic's official agency Eurostat and European commission
reports. From an energetic aspect, the four capitals were considered as a
case study for a food processing plant with annual hot water demand of 43
MWh to evaluate the performance of the solar thermal energy. The simulation
was conducted using T*Sol software considering 16 evacuated-tube collectors
B. Schweizer Energy AG manufacturer. The chosen process heating system has
a buffer tank and a continuous flow heater. Each collector was inclined
according to the optimum angle for each case study. As a result, it was
found that the energy demand in the Visegrád region is entirely related to
the economic situation. In contrast, Political and energy development have
a more significant impact than economic factors. From an energetic aspect,
solar thermal energy is evident for Hungary and Slovakia since they have up
to 20% solar yields compared to Poland and the Czech Republic.
Nevertheless, the solar irradiation on the collector field is high enough
to consider solar thermal energy solutions integrated into food and
industrial processes.
Thermal experimental and numerical heat transfer analysis of a solid cylinder in longitudinal direction
Authors: Cabezas Sebastian , Hegedűs György , Bencs Péter
Published: January 2023

The analysis of heat transfer in solid bodies with orthogonal geometries and knowledge thereof, is of vast importance in different fields of engineering and research. An important field of study is the thermal analysis in machine-parts that in most cases are designed and shaped with orthogonal geometries. Nevertheless, due to the high complexity and the cost that thermal experiments represent, FEM analysis and numerical solutions are used to foresee thermal fields on these components. These methodologies are certainly reliable, although may vary from real experiments. On that account, this paper presents a thermal experimental test in a solid cylinder of length  and  , made of ISO C45 steel that emulates a machine-part (cylindrical parts as shafts, fasteners and the like). The temperature fields along the longitudinal direction  were analyzed in steady and transient state under homogeneous boundary conditions of the first kind (prescribed temperatures at the boundaries). The three solutions, experimental, numerical and FEM simulations were compared with the purpose of validating the results obtained by each method of solution respectively.
Cloud Security Issues in Present Day Context
Authors: Guan Zhimin
Published: January 2023

This research broadly classifies cloud security issues in the present-day context. Over the years, IT experts saw the need of tackling cyber security issues while there is the interaction of software, people, and services through the internet, and what is cyber security? Cloud security is cyber security for safeguarding the cloud environment only. Numerous types of research classify cyber security issues but the list of the issue is still not all-inclusive and hence requires continuous research. This research work throws more light on cloud security issues and is an attempt to make the concept clear not only to serve as a dictionary for IT experts but also to clarify the concept easily to layman who wants to use the cloud for their businesses. The paperwork will make the layman understand the cloud security requirement thereby proving it secure enough and hence encouraging all people to further increase their usage of the cloud for their businesses.
CORPORATE GOVERNANCE, LOGISTICS PRE-POSITIONING, LOGISTICS OUTSOURCING AND ORGANIZATION PERFORMANCE OF SELECTED NON-GOVERNMENT ORGANISATIONS IN UGANDA
Authors: Yassin Kazibwe
Published: January 2023

This study examined the relationship between corporate governance, pre-positioning, logistics outsourcing on performance of Non-Government organizations in Uganda.

This study was a comparative study which applied a quantitative research approach. The sample constituted 138 respondents from Concern Worldwide International &Samaritan Purse International with the help of Krejcie and Morgan 1970 sample selection size. A structured questionnaire and an interview guide were used to obtain data. It was tested for validity using expert judgment, content validity index and factor analysis and reliability using pretesting and Cronbach Alpha Coefficient. Data was analyzed using SPSS version21.0, obtaining descriptive and inferential statistics to interpret findings. This research found a moderate positive relationship between corporate governance, prepositioning, logistics outsourcing and performance of Non-government organizations. Specifically, the study found a moderate positive relationship between Corporate governance and organization Performance. (r=0.593, P≤.0.01), moderate positive relationship between logistics outsourcing and organization performance, (r=0. 560 P≤.0.01), a moderate positive relationship between Logistics prepositioning and organization performance (r=.750, P≤.01) and .884 (R-Square = .179 in the regression model implying that the variables explained 59.2% of the dependent variable. The study found positive relationship between corporate governance, Logistics pre-positioning, logistics outsourcing on performance of Non-government organizations in Uganda (F=19.434, Sig.=.000 The study further discovered that at the center of all these variables lies corporate governance as explained, it was found to be the backbone of the organization. The study further found that the most significant predictor of organization performance is corporate governance. Herein, the study concluded that as far as organization performance wellness is concerned, corporate governance, logistics pre-positioning and logistics outsourcing cannot be taken for granted. The study further concluded that emphasis on corporate governance access will result is extraordinary change in organization performance, and so attention should be directed towards this factor first. The study recommends; putting in place corporate governance mechanisms; full implementation of logistics outsourcing and structuring a logistics pre-positioning network.
Design and Construction of Electric Doorbell
Authors: TORIKPA Icighan
Published: January 2023

The purpose of the project is to design and construct an electric doorbell based on the principle of electromagnetism, powered and controlled by an Arduino circuit board. The goal is to bridge the gap between an old mechanical doorbell and a new Arduino technology and circuit board powered by a 12 volt battery. After the successful construction of the device, it was found to be very useful to the deaf and blind, as the LED component, when activated, blinks and notifies the deaf of the presence of a visitor or someone at the door. It is therefore highly recommended for homes and offices with such disabilities.
Microbially Terraforming Mars
Authors: Ganase Anjali
Published: January 2023

Terraforming Mars begins with altering the physical and chemical composition of Mars to allow other organisms to survive. Increasing the temperature, the availability of liquid water, higher atmospheric nitrogen and oxygen concentrations, and large-scale physical changes are all essential to terraforming Mars. Extremophilic microorganisms that are able to survive Mars's harsh conditions may be a pioneer species on present-day Mars to help change its chemical composition to allow for other microbes to thrive.
TRANSPARENCY OF PUBLICLY AVAILABLE ART CHARGES ON U.S. CLINIC WEBSITES
Authors: Zagadailov Pavel
Published: January 2023

Background: Treatment for ART services is relatively expensive and encourages patients to compare charges among ART clinics. There continues to be increased demand for ART services. Along with these, one would expect increased online searches of ART treatments and corresponding charges. This study evaluated the transparency and informativeness of ART-associated charges publicly available on ART clinic websites across the U.S.

Study design: Evaluation of U.S. ART clinic websites was performed by three raters using a true/false rating scale to determine the availability of the ART- associated charges, including diagnosis, treatment, monitoring, medications, and laboratory services. We evaluated whether academic and non-academic medical centers, geographic location, clinic volume, or ART-mandated and non-mandated coverage for infertility treatment influence the transparency of ART charges. Interrater variability was assessed using modified Fleiss' kappa. Chi-Square analysis was used to test whether DHHS regions, academic versus non-academic hospitals, ART-mandated states versus non-mandated states, and the area's urban character influence the charges displayed. The role of the annual number of total ART cycles on ratings was assessed using the Pearson correlation.

Results: Of the 464 ART clinics evaluated, 84% (n=390) were classified as minimally transparent and informative regarding publicly available ART charges. Of DHHS-designated regions, Region 8 (Denver) had the highest transparency (57.1%, p<0.001) for information on fresh ART cycles. There were no differences among the remaining nine DHHS regions. The ART state mandate, academic affiliation, population density, urbanization level, and clinical volume were not associated with greater transparency of ART charges.

Conclusion: Many ART clinics demonstrate minimal transparency and informativeness of their charges on clinic websites. Analysis of the DHHS regions, ART-mandated states, the role of academia, population density, and level of urbanization suggests that the lack of transparency could be associated with current ART clinic-specific policies.
Evaluating Nigeria’s Millennium Development Goals
Authors: Phil Chibuikem Opute
Published: January 2023

Nigeria is one United Nations member state that is increasingly working on achieving the

Millennium Development Goals (MDGs) which took off at the turn of this century. The

MDGs are eight goals and targets to be attained within 2015. Giving the available time, it

is obvious that it is a major challenge to Nigeria because of its requirements for

actualization in the country. Among the requirements is ensuring effective policy

implementation. However, poor policy implementation is believed by some analysts to be

the bane of development in Nigeria. The paper therefore, seeks to highlight the need for

proper and effective policy implementation while identifying some impediments to be

tackled if Nigeria is to ensure that policies, particularly those relating to the MDGs, are

effectively and timely implemented. These impediments include, among others: corruption,

badleadership, political instability, slow public service structures, ethnicity etc. The paper

posits some sustainable development measures for Nigeria, such as effective use of political

will, eschewing social vices (like ethnicity, favouritism, nepotism and mediocrity), continuity

of policies between governments, eradication of corruption etc.
BIRTH OUTCOMES OF ANEMIA IN PREGNANCY IN BOLGATANGA REGIONAL HOSPITAL
Authors: Mohammed Baba Yahaya , Mohammed Yakubu Damata
Published: January 2023

Background: Anemia during pregnancy is a repetitive peculiarity in Ghana. It can cause drowsiness and mortality in both mother and child and postpone accomplishing manageable improvement objectives, particularly objective 3. The Bolgatanga Regional Hosital continues to record high number of anaemia in pregnancy of the years. The goal of the study was to portray the birth results of anemia in pregnancy and the risk factors related to anemia in Bolgatanga Regional Hospital.

Method: A quantitative method involved 380 pregnant women. A questionnaire was used together with birth results taking verifiable records from the maternal wellbeing record booklet and past data from the client to learn anemia status during

pregnancy and variables that could have added to the anemia.

Results: There were statistically significant differences in anemia levels (hemoglobin levels below 11g/dl) among groups of different educational levels (p < 0.05), marital status anemia in pregnancy (p=.013), and occupation of workers and anemia in pregnancy (P=.001)—the more the gestational age at first contact increases, the tendency to have hemoglobin level decreasing.

Conclusion: Attending ANC services at early gestational age is essential if the woman benefits from iron, folic acid, IPTp, and bed net interventions to prevent anemia and its adverse birth outcomes. Strengthening information, education, and communication (IEC) on early ANC attendance through pregnancy school, health clubs and mass media (Television/Radio) is highly recommended.
ISOLATION CHARACTERISATION AND ANTIMICROBIAL ACTIVITY OF A BIOATIVE COMPOUND FROM ROOTS OF Urena lobata
Authors: emaikwu patience
Published: January 2023

Stigmasterol was isolated from the roots of
Urena lobatausing
1HNMR and
13CNMR. Stigmasterol, n-hexane, ethyl acetate and methanolic extracts were subjected to antimicrobial test using the following microbes:
Methicillin Resistant Staphylococus aureus,
Vancomycin Resistant enterococci, Staphylococus aureus, Escheria coli, Neisseria gonorrhea, Candida albicans, Candida krusei and
Candida stellatoidea. The isolate showed the highest zone of inhibition of 31 mm followed by ethyl acetate extract(28 mm) and methanolic extract (23 mm). The MIC, MBC/MFC result showed that
Staphylococus aureus, Candida kruseiand
Candida stellatoideawere insensitive to both the isolate and plant extracts. The result justifies the use of roots of
Urena lobatain traditional herbal medicine for the treatment of various microbial diseases like menstrual disorder
Gender Equality And The

Empowerment Of Women And Girls

In Nigeria.
Authors: Phil Chibuikem Opute
Published: January 2023

More essentially, women have been subjected to social control and overwhelmed by men. This is ac consequences of enduring social generalization, abuse of strict and conventional practices where

instructive, political and social power are overwhelmed by men, and women have forever been devotees of men in the general public and the men transcendently consider themselves to be head of women. Gender Equality has been an extraordinary issue of worry in Nigeria most particularly among the woman, correspondence among people is simply fair and right. The fulfillment of orientation balance isn't just viewed as an end itself and common freedom issues, however as essential for the accomplishment of practical turn of events and public safety in Nigeria. To answert the difficulties of orientation imbalances, there is a need to perceive the main pressing concerns prompting disparity between sex. The examination technique is as named subjective exploration, with the utilization of essential information traversed directed poll and optional information accumulated from the news print and diaries. The point of the review was to know the significant reasons for orientation imbalance in Nigeria essentially. We additionally proposed methodologies to guarantee orientation correspondence in all areas in Nigeria.
“FUEL THE WORLD” PROJECT ASSESSMENT
Authors: Azeez Raheem
Published: January 2023

With a total revenue of over $2.1 trillion in 2021 so far, the Oil and Gas Exploration and Production industry can be said without doubt to be one of the biggest and most relevant, and yet, highly competitive industry in the world. Based on this fact, one can establish that it is only prudent to carry out a feasibility studies and plan properly before venturing into any product in this industry. Take for instance the level of competitiveness of industry players, the initial capital required, skills and technology, time, risks depending on the nature and location (i.e., either onshore or offshore), as well as the market and price volatility. Hence, it is vital to carryout some feasibility study that takes into account the risk, price and market volatility, profitability, capital requirement, as well as well as performing some cost-benefit analysis. The purpose of this report is to analyze and ascertain the viability of project “FUEL THE WORLD”, analyze its feasibility, forecast its possible cost and benefits, recoverable resources, expected market and price volatility, as well as make representation to the management and shareholders. Main objectives of this report is to analyze the project’s viability and feasibility taking into consideration the following key factors; - Extractable reserves and resources - Capital requirement - Technology, equipment, and skills requirement - Expected future cashflow - Expected future expenses - Market and price volatility - Risk profiles - Revenue/income accruing to both the operating company, personnel, and The State This analysis and report is prepared and carried out by AZ Inc., the official risk analyst, profiler, and adviser of NOVOSIberia Energy (The operating company on the subject i.e. project “Fuel The World”). The project is expected to be carried out in the Western Siberia of Russia which houses the highest E&P activities in Russia.
produção científica sobre estudos de gênero no repositório digital da UFRGS
Authors: Medeiros Thaís Dias , Hoppen Natascha Helena Franz , Vanz Samile Andréa de Souza
Published: January 2023

O presente estudo caracteriza a produção científica sobre estudos de gênero no Lume – Repositório Digital da UFRGS – por meio de análise bibliométrica. O corpus é delimitado pelos documentos sobre estudos de gênero, sexualidade, feminismo e teoria queer. A produção concentra-se nas áreas de Ciências Sociais e Humanidades, Comunicação e Saúde. Os assuntos majoritariamente abordados são: sexualidade, feminismo, estudos culturais, relações de gênero, masculinidades e educação. Conclui-se que a UFRGS produz sobre a temática estudos de gênero, especialmente nas áreas de Ciências Sociais e Humanas, Comunicação e Saúde, e que sua produção na área acompanha o desenvolvimento nacional desse campo de estudo.
Design and simulation of a bearing housing aerospace component from titanium alloy (Ti6Al4V) for additive manufacturing
Authors: Oyesola Moses , Mpofu Khumbulani , Daniyan Ilesanmi , Mathe Ntombi
Published: January 2023

In evaluating emerging technology, such as additive manufacturing, it is important to analyse the impact of the manufacturing process on efficiency in an objective and quantifiable manner. This study deals with the design and simulation of a bearing housing made from titanium alloy (Ti6Al4V) using the selective laser melting (SLM) technique. The Finite Element Analysis (FEA) method was used for assessing the suitability of Ti6Al4V for aerospace application. The choice of Ti6Al4V is due to the comparative advantage of its strength-to-weight ratio. The implicit and explicit modules of the Abaqus software were employed for the non-linear and linear analyses of the component part. The results obtained revealed that the titanium alloy (Ti6Al4V) sufficiently meets the design, functional and service requirements of the bearing housing component produced for aerospace application. The designed bearing is suitable for a high speed and temperature application beyond 1900 K, while the maximum stress induced in the component during loading was 521 kPa. It is evident that the developed stresses do not result in a distortion or deformation of the material with yield strength in the region of 820 MPa. This work provides design data for the development of a bearing housing for AM under the technique of SLM using Ti6Al4V by reflecting the knowledge of the material behaviour under the operating conditions.
Teens, manga and replica shabtis
Authors: Ford Spora Amanda
Published: January 2023

The Teens, Manga and Digitally Produced Replicas Project, which brings together archaeologically charged replicas, members of the ‘youth generation community’ and manga cartoons, forms part of PhD research at the Institute of Archaeology. The research broadly aims to address a need for increased access and investment in understandings of heritage for teens with the use of 3D print replicas through archaeologically driven and active engagement with object-based learning, underpinned by a constructivist learning approach. This research update focuses on one part of the research, which investigates the narratives told through manga cartoons as a demonstration of the access that teen participants developed through engagement with replicas to real ancient objects and the entangled object biographies of both. Manga narratives offer an innovative way for teens to communicate about the Nile Valley funerary figurines from the Kushite kingdom of ancient Sudan which are the subject of the study.
Influence of Abrasion on Corrosive Behavior of a Supermartensitic Stainless Steel in Saline Medium
Authors: Soares Renata Braga , Ma Lian , Liang Hong , Lins Vanessa de Freitas Cunha
Published: January 2023

Supermartensitic stainless steels, with moderate wear and corrosion resistance, are commonly used in the petroleum and gas industry. A setup configured with a potentiostat and a tribometer was developed to study tribocorrosion behavior of a supermartensitic stainless steel. The electrochemical evaluation indicated that under abrasion, the breakdown potential shifted from 73 V toward lower values, reaching −76 mV(Ag/AgCl) by using larger particles. Using the smallest particles, the breakdown potential was the highest. Because of the synergetic effect of wear and corrosion, the concentration of pits was higher with rubbing, but the pit growth was inhibited. The effects of particle size on wear and corrosion were evaluated using diamond particles with a size range of 10–20 μm, 30–40 μm, 40–60 μm, and 140–170 μm. The smallest particles promoted the highest pit growth inhibition and the highest breakdown potential but also the highest passivation current density. The larger abrasive diamond particles decreased the breakdown potential of the supermartensitic stainless steel in a saline solution.
Photothrombotic Middle Cerebral Artery Occlusion in Mice: A Novel Model of Ischemic Stroke
Authors: Conti Emilia , Carlini Noemi , Piccardi Benedetta , Allegra Mascaro Anna Letizia , Pavone Francesco Saverio
Published: January 2023

Stroke is one of the main causes of death and disability worldwide. Over the past decades, several animal models of focal cerebral ischemia have been developed allowing to investigate pathophysiological mechanisms underlying stroke progression. Despite intense preclinical research efforts, the need for noninvasive mouse models of vascular occlusion targeting the middle cerebral artery yet avoiding mechanical intervention is still pressing. Here, by applying the photothrombotic stroke model to the distal branch of the middle cerebral artery, we developed a novel strategy to induce a targeted occlusion of a large blood vessel in mice. This approach induces unilateral damage encompassing most of the dorsal cortex from the motor up to the visual regions 1 week after stroke. Pronounced limb dystonia one day after the damage is partially recovered after one week. Furthermore, we observe the insurgence of blood vessel leakage and edema formation in the peri-infarct area. Finally, this model elicits a notable inflammatory response revealed as a strong increase in astrocyte density and morphologic complexity in the perilesional region of the cortex compared with both other regions of the ipsilesional and contralesional hemispheres, and in sham-operated mice. To conclude, the stroke model we developed induces in mice the light-mediated occlusion of one of the main targets of human ischemic stroke, the middle cerebral artery, free from the limitations of commonly used preclinical models.
DASH/Dam1 complex mutants stabilize ploidy in histone‐humanized yeast by weakening kinetochore‐microtubule attachments
Authors: Haase Max A B , Ólafsson Guðjón , Flores Rachel L , Boakye‐Ansah Emmanuel , Zelter Alex , Dickinson Miles Sasha , Lazar‐Stefanita Luciana , Truong David M , Asbury Charles L , Davis Trisha N , Boeke Jef D
Published: January 2023

Forcing budding yeast to chromatinize their DNA with human histones manifests an abrupt fitness cost. We previously proposed chromosomal aneuploidy and missense mutations as two potential modes of adaptation to histone humanization. Here, we show that aneuploidy in histone‐humanized yeasts is specific to a subset of chromosomes that are defined by their centromeric evolutionary origins but that these aneuploidies are not adaptive. Instead, we find that a set of missense mutations in outer kinetochore proteins drives adaptation to human histones. Furthermore, we characterize the molecular mechanism underlying adaptation in two mutants of the outer kinetochore DASH/Dam1 complex, which reduce aneuploidy by suppression of chromosome instability. Molecular modeling and biochemical experiments show that these two mutants likely disrupt a conserved oligomerization interface thereby weakening microtubule attachments. We propose a model through which weakened microtubule attachments promote increased kinetochore‐microtubule turnover and thus suppress chromosome instability. In sum, our data show how a set of point mutations evolved in histone‐humanized yeasts to counterbalance human histone‐induced chromosomal instability through weakening microtubule interactions, eventually promoting a return to euploidy.
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
Authors: Wang Li‐Min , Wang Pingyuan , Chen Xiao‐Min , Yang Hui , Song Shan‐Shan , Song Zilan , Jia Li , Chen Hua‐Dong , Bao Xu‐Bin , Guo Ne , Huan Xia‐Juan , Xi Yong , Shen Yan‐Yan , Yang Xin‐Ying , Su Yi , Sun Yi‐Ming , Gao Ying‐Lei , Chen Yi , Ding Jian , Lang Jing‐Yu , Miao Ze‐Hong , Zhang Ao , He Jin‐Xue
Published: January 2023

Poly‐ADP‐ribose polymerase (PARP) inhibitors (PARPi) have shown great promise for treating BRCA‐deficient tumors. However, over 40% of BRCA‐deficient patients fail to respond to PARPi. Here, we report that thioparib, a next‐generation PARPi with high affinity against multiple PARPs, including PARP1, PARP2, and PARP7, displays high antitumor activities against PARPi‐sensitive and ‐resistant cells with homologous recombination (HR) deficiency both in vitro and in vivo. Thioparib treatment elicited PARP1‐dependent DNA damage and replication stress, causing S‐phase arrest and apoptosis. Conversely, thioparib strongly inhibited HR‐mediated DNA repair while increasing RAD51 foci formation. Notably, the on‐target inhibition of PARP7 by thioparib‐activated STING/TBK1‐dependent phosphorylation of STAT1, triggered a strong induction of type I interferons (IFNs), and resulted in tumor growth retardation in an immunocompetent mouse model. However, the inhibitory effect of thioparib on tumor growth was more pronounced in PARP1 knockout mice, suggesting that a specific PARP7 inhibitor, rather than a pan inhibitor such as thioparib, would be more relevant for clinical applications. Finally, genome‐scale CRISPR screening identified PARP1 and MCRS1 as genes capable of modulating thioparib sensitivity. Taken together, thioparib, a next‐generation PARPi acting on both DNA damage response and antitumor immunity, serves as a therapeutic potential for treating hyperactive HR tumors, including those resistant to earlier‐generation PARPi.
Analisis Wacana Kritis Berita Pemindahan Ibu Kota Negara Pada Youtube TvOneNews
Authors: Lbs M Akbar Hasyim
Published: January 2023

AbstrakTulisan ini bermaksud untuk membongkar wacana sosial politik secara kritis dengan menganalisis berita pemindahan ibu kota negara di media sosial youtube tvOneNews. Kajian ini menggunakan paradigma kritis dengan pendekatan kualitatif dan menggunakan metode analisis wacana kritis model Teun A. van Dijk. Dalam mengumpulkan data, teknik yang digunakan adalah studi dokumentasi dan telaah isi. Hasil yang diperoleh, dalam dimensi teks berita ini secara umum menegaskan tema pemindahan ibu kota negara yang dibingkai dari sudut pandang sosial ekonomi. Dalam dimensi kognisi sosial tvOneNews berusaha untuk mengkritisi secara tegas langkah-langkah yang diambil pemerintah dalam pemindahan ibu kota negara. Sementara terkait konteks sosial, masyarakat Indonesia sedang berada pada situasi polemik yang mengakibatkan terbelahnya pandangan masyarakat menjadi kelompok pro dan kontra. Penulis melihat kajian semacam ini dapat dikembangkan lebih jauh dengan pendekatan atau model analisis yang berbeda mengingat isu ini akan terus berlanjut dan semakin hangat kedepannya. Abstract This paper intends to critically dismantle socio-political discourse by analyzing the news of the relocation of the nation's capital on the social media youtube tvOneNews.. This study uses a critical paradigm with a qualitative approach and uses the critical discourse analysis method of the Teun A. van Dijk model. In collecting data, the technique used is documentation study and content review. The results obtained, in the dimensions of the news text, generally emphasize the theme of moving the national capital which is framed from a socio-economic point of view. In the dimension of social cognition, tvOneNews tries to strictly criticize the steps taken by the government in relocating the nation's capital city. Meanwhile, related to the social context, the Indonesian people are currently in a polemic situation which has resulted in the splitting of public views into pro and con groups. The author sees that this kind of study can be developed further with a different approach or model of analysis considering that this issue will continue and be warmer in the future.
O Jornal Ideológico é um arquétipo de objeto de aprendizagem que nasce de uma temática, cuja perspectiva controversa oportuniza uma edição com duas versões e cada versão carrega consigo uma interpretação da temática, cujos interesses econômicos e ambientais, por exemplo, podem conduzir o antagonismo de ideias, valores, opiniões e crenças daquele grupo que o produz. Assim, este artigo objetiva identificar contribuições para a formação do licenciando em ciências da UTFPR, com relação à alfabetização científico-tecnológica, ao atuar na construção do jornal ideológico. Observou-se, na construção do jornal ideológico, a valorização das dimensões procedimentais, atitudinais e epistemológicas do conhecimento científico, em equilíbrio com os conhecimentos conceituais
Authors: Melo Marcos Gervânio de Azevedo
Published: January 2023

O Jornal Ideológico é um arquétipo de objeto de aprendizagem que nasce de uma temática, cuja perspectiva controversa oportuniza uma edição com duas versões e cada versão carrega consigo uma interpretação da temática, cujos interesses econômicos e ambientais, por exemplo, podem conduzir o antagonismo de ideias, valores, opiniões e crenças daquele grupo que o produz. Assim, este artigo objetiva identificar contribuições para a formação do licenciando em ciências da UTFPR, com relação à alfabetização científico-tecnológica, ao atuar na construção do jornal ideológico. Observou-se, na construção do jornal ideológico, a valorização das dimensões procedimentais, atitudinais e epistemológicas do conhecimento científico, em equilíbrio com os conhecimentos conceituais. Observou-se também uma importante articulação desse objeto de aprendizagem a eixos estruturantes de alfabetização científica.
The Effect of Employee Agility and Self-Efficacy on Innovative Behavior at Work
Authors: Dzimidienė Agnė , Bagdžiūnienė Dalia
Published: January 2023

In order for organizations to remain competitive and successful in the contemporary business environment, one of the fundamental prerequisites is innovative behavior of employes. Therefore, research analyzing the organizational and personal factors of this behavior is relevant, in which increasing attention is paid to the agility of employees. In general, agility can be described as a person’s ability to adapt quickly and efficiently to normal or new work situations, accept changes and respond appropriately to them. The study aimed to determine the relationship between employees agility, self-efficacy, and innovative behavior in the organization and to evaluate the mediating role of self-efficacy for the relations between agility and innovative behavior. The cross-sectional survey was conducted in the sample of 172 employees. 78% of them were women, the average age of the participants was 33.8 years. Scales measuring employee agility, innovative behavior and self-efficacy were applied in the study. For this study, a Lithuanian employee agility scale consisting of twenty items was prepared. The results were processed using correlational, regression, and mediation analysis. Main results: firstly, more expressed employee agility and self-efficacy predicts their higher involvement in innovative behavior, and secondly, self-efficacy acts as a mediator for the relationship between agility and innovative behavior. The importance of the employee’s personal characteristics – agility and self-efficacy – in predicting innovative behavior was confirmed, and the role of self-efficacy as a mediator for the relationship between agility and innovative behavior was revealed. Theoretical and practical implications of the study results are discussed.
Institutional entrepreneurship in the knowledge based economy
Authors:   National Aviation University, Minochkina Olha
Published: January 2023

The research on entrepreneurship and property institutions in the context of modern transformations of socio-economic systems in the paradigm of modern economic theory are relevant areas of scientific development. It is about changing the basis, and restructuring and creating new forms of development. Institutional entrepreneurship becomes a tool for the formation of a knowledge based society, whose economy depends on the knowledge of its citizens, being the success of such a society depending on innovation and creativity of its citizens. The purpose of the present article is to determine the features and conditions of the development of institutional entrepreneurship in the context of the existing theoretical concepts of the modern development of economy and society, which contribute to the development of the new theory of knowledge based economy and reveal its various aspects. This is about the emergence of an "institutional entrepreneur" with a special type of mentality and economic behavior, corresponding to the new type of social relations, which require modern theoretical research of an interdisciplinary nature using the whole arsenal of methods of institutional political economy. The concept has been developed of management of the property system as a joint-separated resource system, which serves as the institutional basis and determines the functioning of modern economic systems at all levels. That system creates objective conditions for joint-separated activities. The institutional mechanisms of this system ensure the freedom for business entities to realize their own interests, as well as various necessary restrictions serving for common benefit. The development of innovative production, the establishment of social ties, and the comprehensive development of man and his self-reproduction all become real. Such a concept has a consolidating potential. Institutional entrepreneurship is associated with the innovative development of rules and other elements of institutional mechanisms functioning based on intellectualization and humanization of the entire spectrum of social relations, including economic relations. In so doing they perform the role of an instrumental mechanism in the system of drivers in a knowledge based economy. In the process of institutional entrepreneurship, the interdependent processes of social consolidation and strengthening of the state are launched; a new system of social order is created, which regulates the behavior of the main social entities in the context of strategic goals of the state; and the cooperation is established between science, state, national community and world community.
Population dynamics and biotopic distribution of the common hamster (Cricetus cricetus) in Medobory (Podillia)
Authors:   Medobory Natural Reserve (Hrymailiv, Ukraine), Dobryvoda Ivan
Published: January 2023

The results of the surveys and data on biotopic distribution of common hamster burrows in the vicinity of the Medobory Nature Reserve were collected and summarised. In order to study the abundance and density of hamsters, two monitoring sites were established. The first is in the fields between the village of Butsyky and the town of Hrymailiv, and the second is on a farming field in the town of Hrymailiv, where since 2013 the number of common hamster burrows have been recorded in the autumn period of the year. Homestead plots and small-scale plantations of agricultural crops were surveyed using the transect method by one or two investigators. During nine years of research, 170 living burrows were found on the first site, which covers an area of about 10 hectares, and only 7 on the second site, which is located on a farm field. The majority of living burrows were recorded on crops of 3 to 4-year-old alfalfa. An increase in the number of burrows was observed in 2015 and 2019. Additional research was carried out in separate gardens with alfalfa in the vicinity of the town of Hrymailiv, the villages of Lezhanivka, Lychkivtsi, Zelene, and Paivka, and in farm fields, where 52 living burrows were recorded. Separate data were obtained from observation cards of reserve workers and by surveying the local population. The largest colony was found in the village of Lychkivtsi in 2021 in a garden with a four-year-old alfalfa plantation of 0.3 ha, and there were 16 settlements there (3 to 5 burrows per settlements). During nine years of observation, live animals were found only twice: in the village of Butsyky in 2013 (two individuals in a field in fodder beet crops) and near Lezhanivka in 2019 (one individual in a disced rapeseed field, during stork foraging). Usually, they are recorded dead: killed by predators or killed by motor vehicle collisions. Taking into account the distribution of burrows by biotopes, it is worth noting that the decline in the number of hamsters is the result of a decrease in agricultural land area suitable for their existence. The exception is the years 2019–2020, when their number began to increase rapidly, the cause of which could be the mass death of foxes that occurred as a result of poisoning by mouse-like rodents in farm fields in 2018, which served as their food base. As for the animals of the dark morph, their share in the population is no more than 10%, and they often become victims too, since their colouration is clearly visible in their living environs.
Variation in Emergency Department Use of Racemic Epinephrine and Associated Outcomes for Croup
Authors: Walsh Patrick S. , Zhang Yin , Lipshaw Matthew J.
Published: January 2023

OBJECTIVES

Racemic epinephrine (RE) is commonly administered for croup in the emergency department (ED). Our objectives were to examine variation in RE use between EDs, to determine whether ED variation in RE use is associated with hospital or patient factors, and to evaluate the associations between the rates of hospital-specific ED RE use and patient outcomes.

METHODS

We performed a retrospective cohort study using the Pediatric Heath Information System of children aged 3 months to 10 years with croup in the ED. We used mixed-effects regression to calculate risk-standardized proportions of patients receiving RE in each ED and to analyze the relationship between risk-standardized institutional RE use and individual patient odds of hospital admission, ICU admission, and ED revisits.

RESULTS

We analyzed 231 683 patient visits from 39 hospitals. ED administration of RE varied from 14% to 48% of visits (median, 24.5%; interquartile range, 20.0%–27.8%). A total of 8.6% of patients were hospitalized and 1% were admitted to the ICU. After standardizing for case mix and site effects, increasing ED use of RE per site was associated with increasing patient odds of hospital admission (odds ratio [OR], 1.39–95%; confidence interval [CI], 1.01–1.91), but not ICU admission (OR, 1.39; 95% CI, 0.99–1.97) or ED revisit (OR, 1.00; 95% CI, 0.92–1.09).

CONCLUSIONS

In this large, observational study, RE administration varied widely across EDs. Increased RE use by site was associated with increased odds of hospital admission for individual patients when controlling for patient factors. These results suggest further standardization of RE use in children with croup is warranted.