bluuebunny/crossref_metadata_2025 huggingface dataset:
The limits of application of discrediting speech strategy concept in lingvo-expert practice
Authors: Koltunova Elizaveta A. , Zharkov Igor V.
Published: June 2022

The subject of the study is the possibility, feasibility and admissibility of the concept of discrediting speech strategy in the process of carrying out the activities of experts and specialists in the field of forensic linguistic expertise. The relevance of the analysis is due to the existence of a tendency to introduce the concepts of discrediting and the discrediting speech strategy into the norms of the current legislation and (or) the practice of forensic linguistic expertise. In the course of the study, significant features of this speech strategy were identified, and judgment about the relevance of both the concept of a discrediting speech strategy in general and its main tactics for solving a limited range of expert tasks related to identifying signs of humiliation of honor and dig-nity, defamation of business reputation of physical person and (or) legal person, insulting and slander were made and justified (only in cases, when in the disputed text negative information, ex-pressed in the form of an assertion (verifiable) in relation to these persons was identified). An ex-ample of an incorrect appeal to the conceptual framework of the discrediting speech strategy in forensic research conducted for the case of protecting the business reputation of a legal entity was analyzed in detail. Based on the results of the study described in the article, restrictions arising from the nature of forensic activities in the use of the concept of discrediting speech strategy, which are not typical for research activities, were established.
Ukrainian Legislation on National Language Policy and the Reality of Social Processes (1917–2021)
Authors: Mozgovoy Vladimir I.
Published: June 2022

The relevance of the study of Ukrainian language legislation is determined by its mono-national orientation and social inadequacy. The purpose of the article is to uncover the veiled basis of Ukrainization, starting from its terminological understanding by M. Hrushevsky (1907) to the legal consolidation at the level of state building, which covers three stages: the stage of revolutionary and chaotic Ukrainization (1917–1919), the stage of partial Ukrainization within the USSR (1920–1991), and the stage of full Ukrainization of independent Ukraine (since 1991). The latter demonstrates previously hidden directions and methods of modern Ukrainization – the isolation of territories from the Russian world on the basis of the “national idea”, which requires a separate consideration of the Ukrainian legislation that accompanies this process. From the social point of view, its legitimacy is problematic, as it does not contribute to the development of the national language. The definitions of the main functional components of the national-language policy: the concepts of languages of nationalities, native, state, official, regional and non-territorial languages are offered as tools to preserve its cultural potential. It is proven that the contradiction between their objective nature and the subjectivity of ideological interpretations lead to social conflicts, de-stroying the foundations of the state and law. The conclusion is made that the status of languages in a multinational state is established not by political declarations, but by the idea of cultural po-tential preservation of all national communities, regardless of their residence territory and national linguistic identity of its citizens.
Representation of the concept “Doer” in the translation of Antoine de Saint-Exupery’s “The Little Prince” into German
Authors: Ershova Natalia B.
Published: June 2022

The purpose of the study is to determine the language means in the semantic implementation of the concept “Doer” in the translation of Antoine de Saint-Exupery’s “The Little Prince” on the material of the modern German language. We consider Antoine de Saint-Exupery’s fairy tale “The Little Prince” as a special literary genre. The main attention is paid to the description of the means of representation of the concept “Doer” on the material of German, French. The scientific novelty of the work lies in the fact that for the first time the heroes who are presented in the work as figures are singled out, the means of their representation are identified, their belonging to the concept “Doer” is confirmed. As a result of the study, the features of the representation of the concept “Doer” in the translation of the fairy tale “The Little Prince” by A. de Saint-Exupery into German are studied, and a comparison is made of the features of the representation of the concept under study in the original language. We conclude that the concept of “Doer” is represented by using similar constructions in the description of the three characters selected for the study. We determine the prospects for further study of the problem, namely, identifying the features of the means of lexical representation of concepts in the work of A. de Saint-Exupery “The Little Prince” on the material of German and French.
To the sources of the motive of mass psychosis in M.A. Bulgakov’s novel “The Master and Margarita”
Authors: Kolchanov Vladimir V. , Kosyakova Svetlana A.
Published: June 2022

The aim of the work is to analyze the motive of mass psychosis in the novel “Master and Margarita” by M.A. Bulgakov. It is relevant nowadays, when the tendency of close study of madness motive in the writer's works as a particular case of madness motive in Russian literature is outlined in literary criticism. The subject of the research is the consideration of this motive as a technique of parody, creating a unique satirical palette of the sociopolitical life of the country in the era of 1920–1930. Therefore, the methodology of the article includes, along with traditional historical, cultural and mythopoetic approaches, a psychographic commentary. As a result, sources from various humanitarian spheres of human activity are involved in the analysis: fiction, historiography, cultural studies, religion, and psychiatry. Among them: a methodological guide to organizing mass singing “Mass Feasts” (1927) by E.F. Ryumin, , the history of burials in the Vagankovo Cemetery “Men of the Forties” (1869), the novel by A.F. Pisemsky and the related ideology of early twentieth-century literary movements (Symbolism and Proletkult), I.S. Lukash’s emigrant novel “Devil” (1922), a journal version of N. Ognev’s (M. G. Rozanov) novel “Diary of Kostya Ryabtsev” (1926–1928), work by English religion historian D. Robertson “Primordial Christianity” (Russian translation 1930), and N. Kalashnikov’s essay “The Count Cagliostro, the Sorcerer of the Last Century” (1893). Particular emphasis is placed on the psychiatric practice of subduing violent patients. It is concluded that to recreate the motive of mass hysteria Bulgakov’s parody goes from high to low, from laughter to a stamp of horror on the face.
Hubungan Pendidikan dan Pekerjaan Ibu Terhadap Pemberian Asi Ekslusif di Desa Pelem, Kecamatan Purwosari, Kabupaten Bojonegoro
Authors: Farida Farida , Fitriani Ruri Kharisma , Nafiisah Maulidiyatun , Indawati Rachmah
Published: June 2022

Latar Belakang: Air Susu Ibu (ASI) merupakan susu murni dari tubuh ibu yang mengandung banyak zat gizi dan bisa memenuhi kebutuhan tumbuh kembang bayi dengan optimal. Pemberian ASI sudah dilakukan oleh orang Indonesia sejak dulu, tetapi bukan ASI eksklusif melainkan ditambah dengan pemberian susu formula, madu dan makanan tambahan lainnya. Cakupan pemberian ASI eksklusif pada bayi usia < 6 bulan di Kecamatan Purwosari tahun 2019 sebesar 65 (98,5%). Pemberian ASI ekslusif ibu pada bayi dipengaruhi oleh beberapa faktor yaitu faktor Pendidikan dan faktor pekerjaan. 
Tujuan: Tujuan dari penelitian ini untuk menganalisis hubungan antara pendidikan dan pekerjaan ibu terhadap pemberian ASI eksklusif di Desa Pelem, Kecamatan Purwosari, Kabupaten Bojonegoro tahun 2020.
Metode: Penelitian menggunakan desain penelitian kuantitatif dengan metode survey dan pendekatan cross-sectional. Pengumpulan data menggunakan kuisioner wajib tentang 1000 HPK dengan melalukan probing untuk mendapatkan informasi mendalam yang berkaitan dengan pemberian ASI eksklusif.
Hasil: Hasil penelitian menunjukkan sebesar 5,0% ibu di Desa Pelem memberikan ASI eksklusif sedangkan 95,0% ibu di desa pelem tidak memberikan ASI eksklusif. Sebagian besar ibu yang memiliki tingkat pendidikan rendah di desa pelem yaitu sebesar 66,7% dan sebesar 53,3% ibu di desa Pelem menyatakan bahwa mereka bekerja.
Kesimpulan: Ada hubungan antara pendidikan ibu dengan pemberian ASI eksklusif dan tidak ada hubungan antara pekerjaan ibu dengan pemberian ASI eksklusif di Desa Pelem, Kecamatan Purwosari, Kabupaten Bojonegoro.
Kata kunci: Pendidikan, Pekerjaan, ASI Eksklusif
Hubungan Status Gizi (IMT), Kualitas Tidur dan Aktivitas Fisik dengan Kelelahan Kerja Pada Pekerja Bagian Produksi di PT. Coca Cola Bottling Indonesia (Cikedokan Plant/Ckr-B)
Authors: Wulandari Rizki Sri
Published: June 2022

Latar Belakang: Kelelahan kerja merupakan perasaan letih ketika aktivitas fisik telah mengalami penurunan. Kelelahan kerja yang terjadi dapat menurunkan kapasitas kerja dan ketahanan tubuh sehingga dapat membahayakan lingkungan sekitar maupun diri sendiri.Tujuan: Tujuan penelitian ini adalah untuk mengetahui hubungan status gizi (IMT), kualitas tidur dan aktivitas fisik dengan kelelahan kerja pada pekerja bagian produksi.Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain case control. Populasi penelitian yaitu tenaga kerja Bagian Produksi Di PT. Coca Cola Bottling Indonesia (Cikedokan Plant/Ckr-B). Besar sampel dihitung menggunakan rumus Lemeshow didapatkan sebanyak 21 responden kelompok kasus dan 21 responden kelompok kontrol. Data primer bersumber dari kuesioner dan wawancara responden. Data dianalisis menggunakan analisis bivariat uji Chi-Square dan analisis multivariat uji regresi logistik.Hasil: Hasil penelitian menunjukkan adanya hubungan antara status gizi (IMT) (p=0,001, OR=7,913), kualitas tidur (p=0,004, OR=18,687) dan aktivitas fisik (p=0,005, OR=6,435) dengan kelelahan kerja. Yang tidak memiliki hubungan dengan kelelahan kerja adalah adalah usia (p=0,753), masa kerja (p=0,311), shift kerja (p=403), asupan energi (p=0,304), asupan protein (p=0,289), asupan lemak (p=0,289), asupan karbohidrat (p=0,414) dan pola konsumsi (p=1,00).Kesimpulan: Terdapat hubungan status gizi (IMT), kualitas tidur dan aktivitas fisik dengan kelelahan kerja tetapi tidak terdapat hubungan antara usia, masa kerja, shift kerja, asupan energi, asupan protein, asupan lemak, asupan karbohidrat dan pola konsumsi. Peneliti menyarankan untuk pekerja menjaga status gizi (IMT) agar normal serta selalu memanfaatkan waktu dengan baik agar mampu memiliki waktu beristirahat dan menyeimbangkan waktu istirahat tersebut dengan jenis aktivitas fisik yang dijalani setiap hari.
Hubungan Antara Karakteristik Individu Dengan Degenerasi DNA Pada Pekerja Bengkel Pengecatan Mobil Surabaya
Authors: Ulubiah Siti Marifatul , Tualeka Abdul Rohim , Ahsan Ahsan , Jalaludin Juliana
Published: June 2022

Latar Belakang: Kandungan pada komposisi cat maupun thinner terdapat BTX. Kandungan yang digunakan tersebut bersifat toksik dan bahkan karsinogenik. Dengan demikian, paparan BTX yang tidak terkontrol akan menyebabkan gangguan kesehatan pada pekerja. Beberapa metabolit BTX yang menghasilkan produksi ROS dan dapat menyebabkan terjadinya stress oksidatif serta kerusakan genetic. Interaksi yang terjadi antara ROS dengan biomolekul salah satunya DNA dapat menyebabkan terjadinya kerusakan DNA oksidatif. Tingkat keparahan kerusakan DNA juga dapat dipengaruhi oleh karakteristik individu antara lain usia, masa kerja, dan status merokok. Tujuan: untuk menganalisis hubungan antara karakteristik individu dengan degenerasi DNA pada pekerja bengkel pengecatan mobil di Surabaya. Metode: Penelitian ini merupakan penelitian observasional deskriptif dengan analisis kuantitatif dan rancang bangun cross sectional. Sampel penelitian sebanyak 20 orang dengan metode sampling yaitu total population sampling. Penelitian dilakukan di bengkel pengecatan mobil Kalijudan, Surabaya. Variabel penelitian terdiri atas variable independen (karakteristik indvidu meliputi usia, masa kerja, dan status merokok) dan variable dependen (degenerasi DNA). Analisis variable menggunakan tabel distribusi frekuensi, uji coefficient contingency, dan uji korelasi point-biserial. Hasil: Hubungan antara karakteristik individu dengan degenerasi DNA yaitu usia (kategori sedang dan berarah negative), masa kerja (kategori sangat lemah dan berarah negative), dan status merokok (kategori sangat lemah dan berarah positif). Kesimpulan: Hubungan antara karakteristik individu dengan degenerasi DNA pada pekerja bengkel pengecatan mobil di Surabaya berada pada kategori sedang dan sangat lemah dengan arah positif maupun negative. Meski hubungan yang terjadi tidak bersifat kuat, namun pihak industry atau pemilik bengkel pengecatan mobil sebaiknya menyediakan dan menganjurkan pemakaian Alat Pelindung Diri (APD) sebagai bentuk pencegahan terhadap pekerja.
Negative Effects of Social Media Use On Mental Health In Adolescents
Authors: Karinta Aldea
Published: June 2022

Latar Belakang: Media sosial merupakan hal yang lumrah digunakan bagi semua orang, termasuk pada remaja. Ditemukan bahwa remaja yang menggunakan media sosial lebih dari tiga jam per hari berisiko tinggi mengalami masalah kesehatan mental, terutama masalah internalisasi atau citra diri.
Tujuan: Penelitian ini bertujuan untuk membahas tentang penggunaan media sosial dan bagaimana sebenarnya pengaruh media sosial dan efek negatifnya terhadap kesehatan mental.
Metode: Metode yang digunakan adalah studi literatur dari 20 artikel dan jurnal yang diambil dari berbagai sumber yaitu Google Scholar, Google, dan e-book dengan topik yang dibahas yaitu Efek Negatif Penggunaan Media Sosial terhadap Kesehatan Mental pada Remaja.
Hasil: Media sosial dikatakan berdampak negatif bagi kesehatan mental jika digunakan secara berlebihan oleh remaja. Gangguan kesehatan mental yang terjadi akibat media sosial seperti yang disebutkan di atas adalah gangguan kecemasan dan depresi. Selain itu disebutkan juga bahwa media sosial dapat menyebabkan gangguan kesehatan mental yang disebut narsisme, phantom vibration syndrome dan FoMO atau Fear of Missing Out serta gangguan tidur atau insomnia.
Kesimpulan: : Media sosial memiliki dampak negatif pada kesehatan mental. Saat ini, media sosial digunakan oleh hampir semua penduduk bumi. Mayoritas penggunaan media sosial digunakan oleh remaja. Oleh karena itu, penggunaan media sosial harus sangat berhati-hati..
Kata kunci: Kesehatan mental, Media sosial, Remaja.
Hubungan Tingkat Konsumsi dan Pengetahuan Gizi dengan kejadian Kurang Energi Kronis pada Calon Pengantin di Kecamatan Camplong
Authors: Anani Siti Safira
Published: June 2022

Latar Belakang: Calon pengantin merupakan masa prakonsepsi yang tepat untuk mempersiapkan kehamilan. Status KEK pada calon pengantin dapat mempengaruhi kondisi kehamilan dan kesejahteraan bayi yang akan datang.
Tujuan: Mengetahui hubungan tingkat konsumsi dan pengetahuan gizi dengan kejadian kurang energi kronis pada calon pengantin.
Metode: Penelitian ini menggunakan penelitian analitik observasional dengan menggunakan desain cross sectional. Penelitian melibatkan 33 calon pengantin di KUA Camplong yang terdaftar pada bulan Agustus. Peneliti mengukur lingkar lengan atas untuk mengetahui status KEK, 30 pertanyaan untuk mengukur pengetahuan gizi berupa angket, dan food recall 2x24 jam. Analisis data menggunakan chi-square.
Hasil: Terdapat hubungan tingkat konsumsi energi dengan status KEK p < α adalah 0,015.
Kesimpulan: Asupan energi yang cukup dapat mencegah terjadinya kurang energi kronis pada calon pengantin. Konsumsi makanan merupakan salah satu faktor utama penentu status gizi seseorang.
Hubungan Asupan Cairan dan Iklim Kerja dengan Status Hidrasi Pekerja Home Industry Keripik Pisang Lumajang
Authors: Habibati Amanda Fithri , Sa'adah Ulfa Lailatus , Sulistyorini Lilis
Published: June 2022

Background: Most of the body is composed of water. Water is essential for the human body. If water reduction in the human body, dehydration will occur. Therefore it is crucial to meet the needs of fluid consumption. Environmental factors can also cause dehydration, one of which is the work climate. Not all home industries meet the requirements of the work environment and occupational safety and health (OSH) for workersObjectives: To analyze the relationship between fluid intake and work climate with the hydration status of workers in the banana chip home industry LumajangMethods: This research is an observational study. This study uses a quantitative research type as well as a cross-sectional design. Samples were taken by a simple random sampling method so that 26 workers obtained 34 workers in 13 home industries. Univariate analysis with frequency distribution and bivariate with Spearmen rank correlation testResults: There is a relationship between fluid intake (p=0.032) and work climate (p=0.001) with workers' hydration status. A work climate that exceeds the TLV and the need for fluid consumption of fewer than 3.7 liters/day (for men) and 2.7 liters/day (for women) can cause dehydration from mild to severe.  Conclusions: It concluded a significant relationship between work climate and fluid intake with workers' hydration status. Because of, hot working environment and insufficient fluid intake for workers, resulting in dehydration of workers. Recommendations are that employers can meet the fluid intake of workers and are easily accessible for workers and install local exhaust ventilation.
Mental Health and Quality of Life for Health Workers During the COVID-19 Pandemic: A Systematic Review
Authors: Kotijah Siti , Wahyuni Lutfi
Published: June 2022

Background: COVID-19, a strain of the coronavirus that causes acute respiratory syndrome, first appeared in the Chinese city of Wuhan and quickly spread throughout the world in early 2020. The COVID-19 pandemic has changed health care systems around the world and affected the mental health of healthcare workers and their quality of life.Aim: to review the existing scientific evidence regarding mental health and quality of life of health workers during the COVID-19 pandemic.
Methods: This study was taken from the pubmed, ScienceDirect, and Ebsco databases identified between December 2019 to July 2021 and was limited to peer-reviewed research written in English, quantitative research on mental health and quality of life with a cross sectional approach. Articles that fit the criteria are then analyzed using the critical appraisal tool that is appropriate for results of the research.
Results: The results showed an increase in mental disorders, including stress, anxiety, depression, and PTSD in health workers. This is caused by several factors, namely 1) stressors that contribute to the work environment 2) work pressure components, 3) epidemic components, 4) family-related components. This condition can affect the quality of life of health workers.
Conclusion: Research evaluating the direct and indirect association of mental disorders on the mental health of healthcare professionals is urgently needed to improve treatment, mental health care planning and for preventive measures during a potential next pandemic.
Prevention Of Bullying Among Adolescents In The Lens Of Indonesian Policy And Law: Should Nurses Know?
Authors: Wuryaningsih Emi Wuri , Wahyuni Budi , Lusmilasari Lely , Haryanti Fitri
Published: June 2022

Introduction: Indonesia has several institutions, policies, and laws to protect children from all forms of violence, including bullying that impacts physical, psychological, and social health and even death. However, the number of cases of bullying in adolescents still increases. It is related to a lack of knowledge about bullying and is associated with norms in the community.
Method: The analysis uses a discourse analysis approach, "What's the problem represented to be". This method analyzes how the problem of bullying among adolescents is formed, and the forms of bullying prevention are represented in state documents. The analysis steps include: collecting the policy documents related to child protection and health (seven laws and three national policies); Reading the policy text as a whole; rereading the text and underlining the concepts; doing coding and theme analysis; and answering the question.
Results: Three main problems of bullying in adolescents that can be identified include: Theme 1. Terminology of children and adolescents; Theme 2. Children are a vulnerable and disempowered group; Theme 3. Agreement and clarity on child protection related to violence, especially bullying, with perpetrators and victims being children.
Conclusions: Laws and policies have a crucial role in constructing and representing the problem of adolescent bullying in Indonesia. Nurses can use these results to develop adolescent bullying prevention programs through firmness and alignment with policies and legislation.
Cervical Lordosis in Asymptomatic Individuals; Systematic Review and Meta-Analysis
Authors: SARĞIN Gülüm , YENİTÜRK BAYDAR Canan , AZİZOĞLU Hatice
Published: June 2022

Servical omurga omurganın en büyük sagittal hareketine sahiptir ve servical omurga dizilimi torasik sagittal dizilimi etkileyerek fonksiyon ve duruş bakımından oldukça önemlidir. Servical lordozun önemli klinik ve cerrahi etkileri vardır. Servical spinal hastalık bulgusu olmayan bireylerde cervical lordozisin yaş ve cinsiyet ile ilişkisini değerlendirip, cervical lordozisin varlığını ve kapsamını incelemektir. Arama algoritmamızda, 2017 ile 2021 tarihleri arasında yayınlanan araştırmalar dahil edildi. Uygun araştırmalar CINAHL Complete, MEDLİNE, OVİD, Clinical Key ve Google Scholar veritabanları kullanılarak 1 Nisan 2021-25 Mayıs 2021 tarihleri arasında tarama yapıldı. Sadece İngilizce ve Türkçe çalışmalar dahil edildi. Tarama sonrası toplam10.138 başlık ve özet bulundu. Bunların içinden 51 tam metin makale analiz edildi. Analizimize dahil etme- hariç tutma kriterlerimizle toplamda 5 makale dahil edildi. Çalışmaların iki tanesi prospective, iki tanesi retrospective ve bir tanesi de observetional kesitsel türde olduğu belirlendi. Yapılan metaanaliz sonucu cinsiyete göre total eğim lordoz acıları arasında %1’lik bir farklılık olduğu belirlendi. Kadınlarda servikal lordoz açıları arasındaki eğim %2’lik farklılık gösterdi. Aynı şekilde erkeklerde de servikal lordoz açıları arasındaki eğim %2’lik bir farklılık gösterdiği analiz edildi. Servical lordoz stabilizasyonu veya restorasyonu içeren cerrahi müdahalelerde cinsiyet ve yaşa bağlı değişen lordoz eğimleri göz önünde bulundurulmalıdır.
Near-room-temperature reversible switching of quadratic optical nonlinearities in a one-dimensional perovskite-like hybrid
Authors: Fan Qingshun , Ma Yu , Xu Haojie , Song Yipeng , Liu Yi , Luo Junhua , Sun Zhihua
Published: June 2022

The switching of quadratic nonlinear optical (NLO) effects between two or more NLO states of solid-state materials represents an intriguing new branch in the field of photoelectrics and optics. While structural phase transitions have shown potential in this field, near-room-temperature reversible NLO switches have rarely been reported. To exploit new NLO switching materials within the structurally flexible class of hybrid perovskites, here, we synthesize a one-dimensional perovskite-like hybrid, (MP)PbBr3 (where MP+ is a 1-methylpyrrolidinium cation), through a facile solution method, which exhibits strong second harmonic generation (SHG) activities with an intensity of ~1.6 times as large as potassium dihydrogen phosphate. Intriguingly, (MP)PbBr3 enables the near-room temperature reversible switching of SHG properties, showing a large NLO switching contrast of up to ~40 between its SHG-active and SHG-inactive phases, beyond most of its liquid counterparts. Further microscopic structural analyses reveal that the dynamic ordering of the organic MP+ cation and inorganic chain-like skeleton triggers its centrosymmetric (P63/mmc) to acentric (P212121) phase transition at 316 K upon cooling, resulting in a crucial contribution to its NLO switching properties. This work illustrates the potential of this material as a candidate for solid-state NLO switches and will promote the development of NLO materials within the family of low-dimensional hybrid perovskites.
Perceived Health Inequalities: Do the UK and US Public Accurately Estimate Socioeconomic Health Inequality, and Do they Wish to See It Reduced?
Authors: Bridger Emma , Hewett Angela , Comerford David
Published: June 2022

Objective. It is unknown whether the public accurately estimate socioeconomic health inequality and whether they wish to see it reduced or eliminated. Methods. Representative samples of the UK and US indicated the perceived and ideal lifespan of people working in “higher managerial/professional” and “routine” occupations. We present perceived and desired lifespan ratios for each sample and for key socio-demographic variables. Results. The UK public estimated the lifespan of professionals to be 5.9% longer than routine workers (true value of 5.8%), and 67.8% (UK) and 53.7% (US) participants correctly identified that professionals live longer than routine workers. In both populations, the median respondent expressed equal ideal lifespans for routine workers and professional workers. Conclusion. The UK public appear well-appraised on the average lifespan for professionals and routine workers. Across nationalities and most socio-demographic groups, the median respondent was aware of social class inequalities in lifespan and preferred that they be eliminated.
How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula
Authors: Martelli Eugenio , Sotgiu Giovanni , Saderi Laura , Federici Massimo , Sangiorgi Giuseppe , Zamboni Matilde , Martelli Allegra Rosa , Accarino Giancarlo , Bianco Giuseppe , Bonanno Francesco , Bracale Umberto Marcello , Cappello Enrico , Cioffi Giovanni , Colacchio Giovanni , Crinisio Adolfo , De Vivo Salvatore , Dionisi Carlo Patrizio , Flora Loris , Impedovo Giovanni , Intrieri Francesco , Iorio Luca , Maritati Gabriele , Modugno Piero , Monaco Mario , Natalicchio Giuseppe , Palazzo Vincenzo , Petrosino Fernando , Pompeo Francesco , Pulli Raffaele , Razzano Davide , Ruggieri Maurizio Ruggero , Ruotolo Carlo , Sangiuolo Paolo , Vigliotti Gennaro , Volpe Pietro , Biello Antonella , Boggia Pietro , Boschetti Michelangelo , Centritto Enrico Maria , Condò Flavia , Cucciolillo Lucia , D'Amodio Amodio Salvatore , De Laurentis Mario , Desantis Claudio , Di Lella Daniela , Di Nardo Giovanni , Disabato Angelo , Ficarelli Ilaria , Gasparre Angelo , Giordano Antonio Nicola , Luongo Alessandro , Massara Mafalda , Molinari Vincenzo , Padricelli Andrea , Panagrosso Marco , Petrone Anna , Pisanello Serena , Prunella Roberto , Tedesco Michele , Settembrini Alberto Maria
Published: June 2022

Background: To investigate the effects of the COVID-19 lockdowns on the vasculopathic population. Methods: The Divisions of Vascular Surgery of the southern Italian peninsula joined this multicenter retrospective study conducted through cross-sectional survey. Each received a 13-point questionnaire, investigating the hospitalization rate of vascular patients in the first 11 months of the COVID-19 pandemic and in the preceding 11 months. Results: 27 out of 29 Centers were enrolled. April-December 2020 (7092 patients) vs 2019 (9161 patients): post-EVAR surveillance, treatment for Rutherford category 3 peripheral arterial disease, and asymptomatic carotid stenosis revascularization significantly decreased [1484 (16.2%) vs 1014 (14.3%), p=0.0009; 1401 (15.29%) vs 959 (13.52%), p=0.0006; and 1558 (17.01%) vs 934 (13.17%), p<0.0001, respectively]; while revascularization or major amputations for chronic limb-threatening ischemia, and urgent revascularization for symptomatic carotid stenosis significantly increased [1204 (16.98%) vs 1245 (13.59%), p<0.0001; 355 (5.01%) vs 358 (3.91%), p=0.0007; and 153 (2.16%) vs 140 (1.53%), p=0.0009, respectively]. Conclusions: The suspension of elective activities during the COVID-19 pandemic caused a significant reduction in asymptomatic carotid stenosis revascularization, treatment for Rutherford 3 peripheral arterial disease, post-EVAR surveillance. Contestually, we observed a significant increase in urgent revascularization for symptomatic carotid stenosis, and revascularization or major amputations for chronic limb-threatening ischemia.
Terpenes Combinations Inhibit Biofilm Formation in Staphyloccocus aureus by Interfering with Initial Adhesion
Authors: Salinas Claudia De los Angeles , Florentin Gladys Melisa , Rodriguez Fatima , Alvarenga Nelson , Guillén Rosa María
Published: June 2022

The biofilm is a conglomerate of cells surrounded by an extracellular matrix, which contributes to the persistence of infections. The difficulty in removing the biofilm drives the research for new therapeutic options. In this work, the effect of terpenes (-)-trans-Caryophyllene, (S)-cis-Verbenol, (S)-(-)-Limonene, (R)-(+)-Limonene, and linalool was evaluated, individually and in combinations on bacterial growth, by assay with resazurin; the formation of biofilm, by assay with violet crystal; and the expression of associated genes, by real-time PCR, in two clinical isolates of S. aureus, ST30-t019 and ST5-t311, responsible for more than 90% of pediatric infections by this pathogen in Paraguay. All combinations of terpenes can inhibit biofilm formation in more than 50% without affecting bacterial growth. The most effective combination was (-)-trans-Caryophyllene and linalool at a 500 μg/mL concentration for each, with an inhibition percentage of 88%. This combination decreased the expression levels of the sdrD, spa, agr, and hld genes associated with the initial cell adhesion stage and quorum sensing. At the same time, it increased the expression levels of the cap5B and cap5C genes related to the production of capsular polysaccharides. The combinations of compounds tested are promising alternatives to inhibit biofilm formation in S. aureus.
Phenomenological derivation of the thermomechanical diffuse-interface model for electric breakdown
Authors: Zipunova Elizaveta Vyacheslavovna , Savenkov Evgeny Borisovich
Published: June 2022

In this work we derive diffuse-interface type model for electric breakdown evolution in solid dielectrics which accounts for non-isothermal and mechanical effects. The proposed model consists of mass, momentum and energy conservation equation, Maxwell’s equations in quasi(electro)static approximation and Allen-Cahn type equation which describes phase-field evolution. The derivation of the model is based on the rational thermomechanics framework, M. Gurtin’s microforce and microstress theory and Coleman-Noll procedure.
STRATEGY OF INVESTMENT AND INNOVATION ACTIVITIES IN THE CONTEXT OF TRANSFORMATION OF THE NATIONAL ECONOMIC SYSTEM BY TYPES OF ECONOMIC ACTIVITIES
Authors: Kаrаtkevich. A.
Published: June 2022

The article considers an enlarged model of strategic management of the transformation of the national economic system by type of economic activity, including setting a strategic goal specified in tasks, identifying existing internal and external opportunities and determining, based on their comparison, competitive opportunities for transforming the national economic system by type of economic activity, selecting target directions, strategic planning and organizational and economic support for the implementation of strategic plans. Basic investment and innovation strategies for the transformation of the national economic system are proposed, which allow for a comprehensive approach to the issues of substantiating the directions of its innovative transformation by type of economic activity, taking into account the existing innovation and investment potential and opportunities for its growth and use. Based on an enlarged model of strategic management of the transformation of the national economic system and basic investment and innovation strategies for its provision, a methodology for developing and implementing an investment and innovation activity strategy is proposed, including the main stages with the corresponding types of work, characterization of their content and justification of expected results.
Distribution of 222Rn in Seawater Intrusion Area and Its Implications on Tracing Submarine Groundwater Discharge on the Upper Gulf of Thailand
Authors: Wang Yancheng , Chen Guangquan , Yu Hongjun , Xu Xingyong , Liu Wenquan , Fu Tengfei , Su Qiao , Zou Yinqiao , Kornkanitnan Narumol , Shi Xuefa
Published: June 2022

Radon (222Rn) has been widely employed as a tracer for estimating submarine groundwater discharge (SGD). However, the uncertainty of the SGD estimation remains significant, due to the spatial variability of radon in groundwater. In this study, we analyzed the hydrochemical proprieties of seawater and coastal groundwater in the Upper Gulf of Thailand and discussed the distribution characteristics of 222Rn in aquifers in terms of aquifer lithology, groundwater system recharge conditions, and water retention time. The results suggested that the residence time of groundwater and the process of groundwater salinization have the greatest impact on the distribution of 222Rn activity. A 222Rn mass balance model, synthesizing the distribution characteristics of 222Rn in groundwater and tidal influences on SGD, was built to estimate the submarine groundwater discharge in the Upper Gulf of Thailand. The result showed that the SGD flux of the Upper Gulf of Thailand was 0.0203 m/d. Moreover, there is a positive correlation between tidal height and the activity of 222Rn in groundwater. The SGD observed during the low tide was about 1.25 times higher than that observed during the high tide. This may influence the marine geochemical cycles of elements and their impact on marine ecosystems.
Experimental Study of Diffusion and Formation Mineral Change in Supercritical CO2 Huff and Puff Process of Shale Reservoir
Authors: Xu Tianhan , Wang Jian , Lyu Wenfeng , Zhang Yu , Lu Yuhao
Published: June 2022

In order to understand the diffusion during CO2 huff and puff in the development of shale oil and its influence on the formation, expansion and viscosity reduction experiments of shale oil-CO2 system, CO2 extraction experiments, and CO2 huff and puff physical simulation experiments were conducted. The diffusion characteristics of CO2 during huff and puff and their effects on formation minerals were studied by chromatographic analysis and X-ray diffraction analysis of artificially fractured natural cores. Research indicates that CO2 huff and puff technology is an effective method to enhance the recovery of shale reservoirs after fracturing. By injecting CO2, the light components of shale oil can be effectively extracted; when the amount of injected CO2 is 50%, the saturation pressure of shale oil increases to 27.72 MPa, and the expansion coefficient increases by 27.9%, the viscosity reduction rate of shale oil can reach 58.97%, and the density reduction rate is 10.02%; under the soaking well pressure of 50 MPa, when 0.5PVCO2 was injected and the well stuffed for 8 hours, the CO2 was fully dissolved in the shale oil, and the continuous increase of the injection slug had a little effect on the CO2 diffusion. During the CO2 huff and puff process, CO2 would dissolve in the formation water and fracturing fluid and reacts with dolomite in the reservoir rock, consuming a large amount of dolomite in the reservoir, and the dolomite mineral content of core sample decreased from 30.1% to 2.6%.
Análisis de la gestión de Prohvilla en los Pantanos de Villa periodo 2018
Authors:   , De La Vega Pacchioni Gustavo Raul
Published: June 2022

Los humedales como los Pantanos de Villa, que tienen la categoría de Sitio Ramsar y de Refugio de Vida Silvestre, nos dan el indicativo de su relevancia internacional respecto del medio ambiente y la biodiversidad. Asimismo, su ubicación en Lima (capital de Perú) nos obliga a tener un cuidado especial por los servicios ecosistémicos que nos ofrecen y que este puede estar en peligro por una serie de amenazas como lo son los impactos generados por las diversas actividades antrópicas. Por lo señalado, la administración pública tiene la tarea de desempeñarse eficazmente para satisfacer las necesidades de los administrados, pero también para la preservación de sitios tan importantes como los Pantanos de Villa y ejecutar sus propios objetivos proyectados en su Plan Operativo Anual, que suponen son elaborados por qué la institución encargada observa una necesidad de gestión en pro de la conservación del medio ambiente como podemos verificar en el presente trabajo. Para efectos de este trabajo se desarrollará un análisis de la administración 2018 de PROHVILLA correspondiente a la Oficina de Control y Fiscalización - OFC, a través de instrumentos técnicos y legales, como el Plan Operativo Anual - POA, la memoria anual, normas con rango de ley, entre otros.
Caídas y su asociación con efectos adversos al tratamiento antineoplásico en adultos mayores varones
Authors:   , Enriquez Cordova Lexa Mirtha , Aillot Paico Isamar Cristina
Published: June 2022

Introducción: El cáncer en adultos mayores es un problema de salud, donde las caídas suelen ser frecuentes, provocando lesiones que afecten su rutina. Proponer a las caídas como un factor de riesgo en el contexto de la evaluación oncogeriatría sería un punto de partida para prevenir potencialmente los efectos adversos, ya sea como un indicador de fragilidad, vulnerabilidad, sarcopenia, entre otros. Objetivo: Determinar la asociación entre caídas y los efectos adversos al tratamiento antineoplásico en adultos mayores varones del Centro Médico Naval del Perú. Material y Métodos: Estudio observacional, cohorte retrospectiva, de un análisis secundario de una base de datos del estudio original. Se obtuvo información de 908 participantes geriátricos retirados con diagnóstico de cáncer que iniciaron o que aún no iniciaban tratamiento antineoplásico desde 2013 al 2015. Se realizó un modelo de regresión de Cox para determinar el riesgo de efectos adversos al tratamiento antineoplásico con antecedentes de caídas, edad, estado civil, comorbilidades, consumo de tabaco, circunferencia de pantorrilla, fragilidad, dependencia funcional, polifarmacia y vulnerabilidad. Resultados: El 43.6% de los pacientes presentaron caídas, mientras el 24.6% tuvieron algún efecto adverso. En la regresión de Cox se halló en el modelo ajustado se encontró que las caídas independientemente de las covaribales, aumentaron 2.02 (1.84-2.21) veces de efectos adversos. Se encontró asociación estadísticamente significativa con las demás covariables. Además, se halló que los efectos adversos de tipo quimiotoxicidad fue del 56.83% y complicaciones quirúrgicas fue del 32.16%, siendo estas las más frecuentes. Conclusiones: La presencia de caídas, independientemente de las comorbilidades, la funcionalidad, la vulnerabilidad y demás covariables, aumenta el riesgo de efectos adversos al tratamiento antineoplásico.
Asociación entre el Síndrome de Riesgo Motor Cognitivo con complicaciones terapéuticas en adultos mayores varones con cáncer
Authors:   , Zevallos Villanueva Lesly Dayano , Valverde Graciano Leonila Jackeline
Published: June 2022

Objetivos: Evaluar la asociación entre el síndrome de riesgo motor cognitivo (SRMC) y el desarrollo de complicaciones por radiotoxicidad, quimiotoxicidad, y efectos adversos por manejo quirúrgico en pacientes hombres con cáncer. Diseño: Estudio de cohortes retrospectivo y análisis secundario de una base de datos recopilada entre 2012 y 2015. Población: Pacientes hombres adultos mayores con cáncer que recibieron quimioterapia, radioterapia, y/o intervención quirúrgica y atendidos en el departamento de Geriatría por consulta externa del hospital Central Médico Naval del Perú. Medidas: El diagnóstico de SRMC fue determinado usando los criterios de Beauchet, y los efectos adversos fueron medidos usando los criterios de terminología común para eventos adversos v4.0. Resultados: En el modelo ajustado todas las variables, excepto edad, demostraron que los participantes con SRMC tenían un riesgo de 2.32 veces mayor de presentar complicaciones que sus pares sin este síndrome (IC 95%: 1.59-2.45). Conclusión: El presente estudio demostró por primera vez un incremento del riesgo de desarrollar complicaciones relacionas a tratamiento antineoplásico en pacientes adultos mayores diagnosticados con SRMC, sugiriendo la necesidad de evaluar dominios motores y cognitivos en estos pacientes para predecir posibles riesgos.
Prevalencia de desórdenes del balance de agua y sodio después de cirugía selar y supraselar por adenoma hipofisiario: revisión sistemática y metaanálisis
Authors:   , Balbin Flores Catherine , Porras De La Cruz Liz Lorena
Published: June 2022

Objetivo: Determinar la prevalencia del desarrollo de trastornos de agua y sodio post-cirugía selar y supraselar por adenoma hipofisario en pacientes adultos y pediátricos. Metodología: Se realizó una revisión sistemática utilizando los buscadores de PubMed, Scopus, SciELO y Web of Science hasta enero del 2022. Se incluyó únicamente estudios de cohorte que evaluaron alguna complicación hidroelectrolítica posterior a la cirugía selar o supraselar por cualquier tipo de adenoma hipofisario, excluyéndose aquellos estudios que incluyeron pacientes que experimentaron más de una cirugía por adenoma hipofisario o los trastornos del equilibrio hídrico y sódico que no pudieron ser confirmados. Resultados: Se incluyeron 94 estudios, que incluyeron 20593 pacientes entre adultos (n=20182) y pediátricos (n=411). Se encontró una prevalencia de diabetes insípida de 17.69% (IC95% 13.76 – 21.97, I2: 97.41%) y 8.04% (IC95% 4.35– 12.45, I2: 0%), para la población adulta y pediátrica respectivamente, y de 16.81% (IC95% 13.45 – 20.45, I2: 96.98%), y 25.75% (IC95% 18.11 – 33.98, I2: 0%), después de una cirugía transesfenoidal y transcraneal respectivamente. Siendo la más frecuente la diabetes insípida de tipo transitoria en ambos grupos etarios y tipos de cirugía. Otros trastornos hidroelectrolíticos tuvieron una prevalencia menos del 1%. De acuerdo al continente, la prevalencia de diabetes insípida es de 15% para Europa, 17% para Asia y América. Conclusiones: El desorden más común fue la diabetes insípida, siendo más frecuente su presentación en la población adulta y posterior a una cirugía transcraneal. Es necesario realizar un manejo activo en la búsqueda de alteraciones en la vasopresina para prevenir las complicaciones del desorden hidroelectrolítico.
Asociación entre fragilidad y síntomas depresivos en adultos mayores atendidos por telemedicina
Authors:   , Roman Lopez Marcelo Sebastian , Tupac Bonifacio Rosario Laura
Published: June 2022

Antecedentes y objetivo: El síndrome de fragilidad y la presencia de síntomas depresivos engloban dos grandes síndromes que en la población geriátrica aumentan el riesgo de morbi-mortalidad. El objetivo del estudio es determinar la asociación entre síntomas depresivos y fragilidad clínica en adultos mayores atendidos por telemedicina en un distrito de Lima-Perú, para así manejar el síndrome de fragilidad y la depresión como problemas correlacionados en un adulto mayor, ya que son factores premonitores de problemas de salud en éstos aumentando la morbi-mortalidad. Materiales y métodos: Se realizó estudio observacional, analítico, transversal, que consistió en un análisis primario de una base de datos. Se analizó la información de adultos mayores de 60 años residentes en Chaclacayo (Lima, Perú). Mediante la regresión de Poisson se calculó las razones de prevalencia e intervalos de confianza al 95%. Resultados: Se incluyeron 274 participantes con una edad promedio de 71.93 años con una desviación estándar de 8.46, en su mayoría del sexo femenino siendo 51.46% (n=141). Se encontró una alta frecuencia de síntomas depresivos en los pacientes con fragilidad y con la ayuda de la regresión de Poisson determinamos que tener síntomas depresivos se asocia con una probabilidad 6.99 veces mayor de tener fragilidad en comparación a los que no cuentas con éstos. Conclusión: Se concluyó que los síntomas depresivos aumentan las probabilidades de tener fragilidad clínica en adultos mayores, por lo tanto, están asociadas.
Comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from SCLC: Study protocol for a randomized controlled trial
Authors: Zhang Xiaofang , Wang Tianlu , Wang ChenYu , Zhao Peng , Huang Bo , He Lei , Song YingQiu
Published: June 2022

BackgroundThis study is in regard to the comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from small cell lung cancer (SCLC). Therapeutically, they have notably varying dose distributions. Based on theoretical and model studies, it has long been speculated that these modes may result in different prognostic outcomes. We aim to assess the efficacy of tomotherapy in the treatment of SCLC brain metastases while protecting the key functional area, the hippocampus, and minimizing any neurocognitive impairments incurred by radiation.MethodsThis is a randomized, controlled, prospective study including 102 SCLC patients with brain metastases randomized (1:1) to the experimental (whole brain radiation therapy for synchronous brain metastases with irradiation to protect the hippocampus) or control (whole brain radiotherapy for sequential brain metastases to boost irradiation) group. The sample size is calculated through a single-sided test; 102 participants will be required for the main results to have statistical and clinical significance. We aim to provide clinical trial data support for better prognostic treatment options in patients with SCLC and brain metastases. The clinical trial data include both the primary and secondary outcomes; the primary outcome is the intracranial progression-free survival time after the new technology application. The secondary study outcomes include the assessment of neurological function, the quality of life, and the overall survival rate. Follow-up consultations will be conducted every 2 months. After the final patient completes follow-up, Statistical Product and Service Solutions software will be used for scientific and rigorous data analysis. Version 1.0 of the protocol was implemented on January 1, 2021; the recruitment process for this clinical trial commenced on April 1, 2021 and will end on March 31, 2024.DiscussionThe study will provide high-quality clinical evidence to support the efficacy and safety of whole brain radiation therapy for synchronous brain metastases with dose irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases with push volume irradiation for the treatment of patients who have lung cancer as well as brain metastases. This has not been previously reported.Trial registrationThis trial is registered with the Chinese Clinical Trial Registry (ChiCTR1900027539; November 17, 2019)