bluuebunny/crossref_metadata_2025 huggingface dataset:
Experiência Estética: Constituindo Professores de Arte
Authors: Pessi Maria Cristina Alves dos Santos
Published: October 2018

Este texto refere-se à formação de professores de arte e as experiências estéticas vividas.Experiência estética é aqui tratada nos termos da estética pragmatista de John Dewey.
A Escola e o Museu de Arte
Authors: Coelho Roseane Martins
Published: October 2018

Este artigo é um relato da experiência de uma pesquisa-ação cultural em desenvolvimento pelo Museu de Arte de Santa Catarina-MASC com três escolas públicas de Florianópolis.Trata-se da apresentação do projeto, seus pressupostos metodológicos e alguns resultados, ainda que parciais, uma vez que é um projeto que está em andamento.
As várias faces de uma história Autores
Authors: Bonilha Maria Paula Carvalho , Massa Nei , Moretti Maria de Fátima
Published: October 2018

0 presente texto tem como objetivo relatar a experiência da oficina As Várias faces de uma história, desenvolvida pelos bolsistas de Artes Cênicas no âmbito do NUPEART, projeto que alia ensino, pesquisa e extensão na Universidade de Estado de Santa Catarina.
Os professores e a escola: lidando com a diversidade étnica
Authors: Clemêncio Maria Aparecida
Published: October 2018

Este texto é um convite à reflexão, com o propósito de instigar a curiosidade dos professores, incluindo os de arte, a pensar e trazer para o cotidiano da sala de aula, o respeito e atenção com grupos étnicos não hegemônicos, neste caso específico, dos afrodescendentes. Promover o debate sobre a importância de se incluir nos cursos de formação de professores, o estudo sobre a diversidade étnica é uma de nossas preocupações. Focalizaremos as questões da diversidade, a partir da etnia afrodescendente, para compreendermos e valorizarmos as questões da diferença étnica/racial na educação. Nesta perspectiva, apontamos limitações e possibilidades nas práticas pedagógicas na relação com as identidades diferenciadas, no sentido de fomentar e estimular os professores a refletirem sobre as diferenças étnicas na escola.
Experiências didáticas com o teatro de sombras
Authors: Knabben Julie Cristie
Published: October 2018

Este artigo trata da experiência dos graduandos do curso de Licenciatura em Artes Cênicas da UDESC, que durante três meses colocaram a teoria em prática, num projeto facilitado pela universidade. Traz um resumo da trajetória do teatro de sombras do oriente para o ocidente com o título: “Do Oriente à sala de aula”. Esclarecendo as implicações desta passagem, refletindo as transformações culturais e as maneiras de aplicação didática da linguagem. O processo de trabalho realizado na oficina é descrito através das metodologias aplicadas e sua análise, bem como uma conclusão sobre os resultados obtidos.
A CULTURA NO ESPAÇO VIRTUAL: NOVAS APRENDIZAGENS PARA O PROFESSOR DE ARTE
Authors:   UDESC, Rosa Maria Cristina da
Published: October 2018

Este artigo tem como objetivo propor uma reflexão acerca das transformações ocorridas na cultura a partir do ambiente virtual. Este movimento cultural exige do professor novas aprendizagens que possibilitem a utilização destes mecanismos na sua atividade pedagógica. Considera-se o ambiente virtual uma ferramenta para ampliar o acesso do professor de arte à informação e também como apoio para a formação continuada. Destacam-se, desta forma, as transformações ocorridas na cultura de aprendizagem convencional para as novas estratégias criadas a partir das necessidades de aprendizagem do aluno virtual, especialmente o professor em formação.
Lifestyle changes associated with osteopathic medical education
Authors: Hudgins Patricia M. , Crapse Fred J. , Baker Helen H.
Published: October 2018

A written survey of second-year osteopathic medical students at West Virginia School of Osteopathic Medicine was conducted to determine if detrimental lifestyle changes had occurred in the first 15 months of their medical education. Fifty-two (790/0) of the 66 students returned the survey. The large majority of the responders (96%) reported a detrimental alteration in at least one area, and 81%, in two or more of the four areas surveyed. Changes in eating patterns were indicated by 79% of responding students. Increases in caffeinated beverage consumption were reported by 71% of respondents, and decreases in activity level, by 78%. Weight gains were indicated by 64% of respondents. Entering students should be advised of the risk that detrimental lifestyle changes may occur during their osteopathic medical . education and be encouraged to prevent these harmful changes.
Effective population sizes and adaptive genetic variation in a captive bird population
Authors: Athrey Giridhar , Faust Nikolas , Hieke Anne-Sophie Charlotte , Brisbin I. Lehr
Published: October 2018

Captive populations are considered a key component ofex situconservation programs. Research on multiple taxa has shown the differential success of maintaining demographic versus genetic stability and viability in captive populations. In typical captive populations, usually founded by few or related individuals, genetic diversity can be lost and inbreeding can accumulate rapidly, calling into question their ultimate utility for release into the wild. Furthermore, domestication selection for survival in captive conditions is another concern. Therefore, it is crucial to understand the dynamics of population sizes, particularly the effective population size, and genetic diversity at non-neutral and adaptive loci in captive populations. In this study, we assessed effective population sizes and genetic variation at both neutral microsatellite markers, as well as SNP variants from the MHC-B locus of a captive Red Junglefowl population. This population represents a rare instance of a population with a well-documented history in captivity, following a realistic scenario of chain-of-custody, unlike many captive lab populations. Our analyses, which included 27 individuals comprising the entirety of one captive population show very low neutral and adaptive genetic variation, as well as low effective sizes, which correspond with the known demographic history. Finally, our study also shows the divergent impacts of small effective size and inbreeding in captive populations on microsatellite versus adaptive genetic variation in the MHC-B locus. Our study provides insights into the difficulties of maintaining adaptive genetic variation in small captive populations.
Dynamic Covalent Self‐Assembly Based on Oxime Condensation
Authors: Shen Libo , Cao Ning , Tong Lu , Zhang Xinjiang , Wu Guangcheng , Jiao Tianyu , Yin Qi , Zhu Jiaqi , Pan Yuanjiang , Li Hao
Published: October 2018

Oxime, whose dynamic nature was reported to be switchable between ON/OFF by tuning the acidity, is employed in a novel type of dynamic covalent approach that is amenable to use in water for self‐assembly of purely organic molecules with complex topology. In strongly acidic conditions, the dynamic nature of oxime is turned ON, allowing occurrence of error‐checking and therefore a catenane and a macrocycle self‐assembled in high yields. In neutral conditions, oxime ceases to be dynamic, which helps to trap the self‐assembled products even when the driving forces of their formation are removed. We envision that this switchable behaviour might help, at least partially, to resolve a commonly encountered drawback of dynamic covalent chemistry, namely that the intrinsic stability of the self‐assembled products containing dynamic bonds, such as imine or hydrazone, are often jeopardized by their reversible nature.
Engineered mesoporous ionic‐modified γ‐Fe2O3@hydroxyapatite decorated with palladium nanoparticles and its catalytic properties in water
Authors: Pashaei Mokhtar , Mehdipour Ebrahim , Azaroon Maedeh
Published: October 2018

A new mesoporous organic–inorganic nanocomposite was formulated and then used as stabilizer and support for the preparation of palladium nanoparticles (Pd NPs). The properties and structure of Pd NPs immobilized on prepared 1,4‐diazabicyclo[2.2.2]octane (DABCO) chemically tagged on mesoporous γ‐Fe2O3@hydroxyapatite (ionic modified (IM)‐MHA) were investigated using various techniques. The synergistic effects of the combined properties of MHA, DABCO and Pd NPs, and catalytic activity of γ‐Fe2O3@hydroxyapatite‐DABCO‐Pd (IM‐MHA‐Pd) were investigated for the Heck cross‐coupling reaction in aqueous media. The appropriate surface area and pore size of mesoporous IM‐MHA nanocomposite can provide a favourable hard template for immobilization of Pd NPs. The loading level of Pd in the nanocatalyst was 0.51 mmol g−1. DABCO bonded to the MHA surface acts as a Pd NP stabilizer and can also lead to colloidal stability of the nanocomposite in aqueous solution. The results reveal that IM‐MHA‐Pd is highly efficient for coupling reactions of a wide range of aryl halides with olefins under green conditions. The superparamagnetic nature of the nanocomposite means that the catalyst to be easily separated from solution through magnetic decantation, and the catalytic activity of the recycled IM‐MHA‐Pd showed almost no appreciable loss even after six consecutive runs.
Solvent‐free synthesis of propargylamines catalyzed by an efficient recyclable ZnO‐supported CuO/Al2O3 nanocatalyst
Authors: Sotoudehnia Zohreh , Albadi Jalal , Momeni Ahmad Reza
Published: October 2018

An efficient nanocatalyst of ZnO‐supported CuO/Al2O3 (CuO/ZnO/Al2O3 nanocatalyst) was prepared by the co‐precipitation method and characterized by scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, X‐ray powder diffraction and Brunauer–Emmett–Teller surface area analysis. CuO/ZnO/Al2O3 nanocatalyst proved to be a very efficient catalyst on the synthesis of propargylamines under solvent‐free conditions in high yields. Moreover, the catalyst can be recyclable without reducing catalytic activity up to five times.
Effect of gas–liquid ratio on the wall shear stress in slug flow in capillary membranes
Authors: Kumari Sadhana , Kumar Nilay , Gupta Raghvendra
Published: October 2018

The membrane processes generally suffer from the fouling caused by the deposits at the membrane surface and membrane pores. In recent years, gas–liquid flow has been shown to be an effective method of membrane fouling prevention. Among the different flow regimes that occur during gas–liquid flow through membrane capillaries, slug flow has been observed to be the most effective for enhancement of permeate flux. The shearing caused by the fluid on the membrane wall is the primary factor causing fouling removal. Previous studies in the slug flow regime suggest that the major contribution to the wall shear stress comes from the bubble front and rear regions and the contribution from the constant film thickness region in the middle is negligible. Therefore, the average wall shear stress in the slug flow regime is dependent on the bubble length. In this work, two‐phase gas–liquid flow in a capillary has been modeled computationally to understand the effect of bubble length on the wall shear stress. Further, the effect of liquid viscosity on the wall shear stress has also been studied for capillary numbers ranging from 0.0037 to 0.098. The volume‐of‐fluid method has been employed to capture the gas–liquid interface between the two phases. The results have been compared with a simple phenomenological model for wall shear stress available in literature and found to be in good agreement for long Taylor bubbles.
Long‐Term Operation of Perovskite‐Catalyzed Bifunctional Air Electrodes in Rechargeable Zinc‐Air Flow Batteries
Authors: Pichler Birgit , Mayer Kurt , Hacker Viktor
Published: October 2018

Rechargeable zinc‐air flow batteries are investigated as promising stationary energy storage system due to compact system design and low cost materials. Bifunctional air electrodes employing a La0.6Sr0.4Co0.2Fe0.8O3 perovskite catalyst for O2‐reduction and O2‐evolution are manufactured in small scale (4 cm2) and in up‐scaled sizes (50–55 cm2) and tested in unit cell configuration with flowing electrolyte. Stable operation of 1000 h is achieved in the small set‐up with an overall 1800 h of operation over 700 cycles at high voltage efficiencies of >50 % (air electrode) at 50 mA cm−2. The up‐scaled flow cell reaches nearly the same performance for 320 h and 130 h, respectively, proving the successful scale‐up. Slowly decreasing hydrophobicity is found to be the main reason of initially increasing but then decreasing performance. This is confirmed by electrochemical impedance spectroscopy. Although many problems are suppressed with flowing electrolyte, zinc morphology proves to be the major challenge especially in larger cells in long‐term operation of a few hundred hours.
Efflux excretion of bisdemethoxycurcumin‐O‐glucuronide in UGT1A1‐overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance‐associated proteins 1 (MRP1) as the glucuronide transporters
Authors: Yang Jing , Zhang Beibei , Qin Zifei , Li Shishi , Xu Jinjin , Yao Zhihong , Zhang Xiaojian , Gonzalez Frank J , Yao Xinsheng
Published: October 2018

Bisdemethoxycurcumin (BDMC) was a natural curcuminoid with many bioactivities present in turmeric (Curcuma longa L.). However, the disposition mechanisms of BDMC via uridine 5′‐diphospho‐glucuronosyltransferase (UGT) metabolism still remain unclear. Therefore, we aimed to determine the potential efflux transporters for the excretion of BDMC‐O‐glucuronide. Herein, chemical inhibition assays (Ko143, MK571, dipyridamole, and leukotriene C4) and biological inhibition experiments including stable knocked‐down of breast cancer resistance protein (BCRP), multidrug resistance‐associated proteins (MRPs) transporters were both performed in a HeLa cell line stably overexpressing UGT1A1 established previously. The results indicated that Ko143 (5 and 20 μM) caused a marked reduction in excretion rate (18.4–55.6%) and elevation of intracellular BDMC‐O‐glucuronide (28.8–48.1%), whereas MK‐571 (5 and 20 μM) resulted in a significant decrease in excretion rate (6.2–61.6%) and increase of intracellular BDMC‐O‐glucuronide (maximal 27.1–32.6%). Furthermore, shRNA‐mediated silencing of BCRP transporter led to a marked reduction in the excretion rate (21.1–36.9%) and an obvious elevation of intracellular glucuronide (24.9%). Similar results were observed when MRP1 was partially silenced. In addition, MRP3 and MRP4 silencing both displayed no obvious changes on the excretion rate and intracellular levels of glucuronide. In conclusion, chemical inhibition and gene silencing results both indicated that generated BDMC‐O‐glucoside were excreted primarily by the BCRP and MRP1 transporters. © 2018 BioFactors, 44(6):558–569, 2018
Alteration in serum concentrations of FGF19, FGF21, and FGF23 in patients with urothelial carcinoma
Authors: Li Jian‐Ri , Chiu Kun‐Yuan , Ou Yen‐Chuan , Wang Shian‐Shiang , Chen Chuan‐Su , Yang Cheng‐Kuang , Ho Hao‐Chung , Cheng Chen‐Li , Yang Chi‐Rei , Chen Cheng‐Che , Wang Shu‐Chi , Lin Chia‐Yen , Hung Sheng‐Chun , Hsu Chiann‐Yi , Chen Chun‐Jung
Published: October 2018

Fibroblast growth factors (FGF) 19, 21, and 23 have been reported as functional factors in human metabolic diseases and malignancies. We performed a prospective survey to compare circulating FGF levels in urothelial carcinoma (UC) patients and normal controls. Between 2016 and 2017, 39 patients with UC of the urinary bladder or upper urinary tract who received surgical intervention were included. All the serum samples were obtained before surgeries. The control group included 28 healthy volunteers. Analysis of the circulating FGF19, 21, and 23 levels among all 67 subjects, as well as a subgroup analysis of the 39 UC patients were performed. The median levels of serum FGF19, 21, and 23 in the UC patients were 84.2, 505.3, and 117.6 pg/mL, respectively, which were statistically different from levels found in the healthy controls (P = 0.015, <0.001 and < 0.001, respectively). In the subgroup analysis, the FGF19 and FGF21 levels were significantly higher in end‐stage renal disease UC patients, while FGF21 was also higher in the UC patients with cardiovascular diseases and history of recurrent UC. In the receiver operating characteristic (ROC) curve analysis, FGF19, 21, and 23 were all significant predictors of UC [area under the curve (AUC)] 0.674, P = 0.015; AUC 0.918, P < 0.001; AUC 0.897, P < 0.001, respectively). In UC patients, serum FGF19 level was significantly lower, while FGF21 and 23 were significantly higher, than respective levels in healthy controls. All three markers may serve as good predictors of UC occurrence, and FGF21 level was associated with disease recurrence. © 2018 BioFactors, 45(1):62–68, 2019
Population-based study of outcomes following an initial acute diverticular abscess
Authors: Aquina C T , Becerra A Z , Xu Z , Justiniano C F , Noyes K , Monson J R T , Fleming F J
Published: October 2018

Background

Studies examining long-term outcomes following resolution of an acute diverticular abscess have been limited to single-institution chart reviews. This observational cohort study compared outcomes between elective colectomy and non-operative management following admission for an initial acute diverticular abscess.

Methods

The Statewide Planning and Research Cooperative System was queried for unscheduled admissions for an initial acute diverticular abscess in 2002–2010. Bivariable and propensity-matched multivariable analyses compared stoma rates and use of healthcare in patients who had an elective resection and those receiving non-operative management. Diverticulitis recurrence rates were analysed for non-operative management.

Results

Among 10 342 patients with an initial acute diverticular abscess, one-third (3270) underwent surgical intervention within 30 days despite initial non-operative management. Of the remaining 7072 patients, 1660 had an elective colectomy within 6 months. Of 5412 patients receiving non-operative management, 1340 (24·8 per cent) had recurrence of diverticulitis within 5 years (median 278 (i.q.r. 93·5–707) days to recurrence). Elective colectomy was associated with higher stoma rates (10·0 per cent, compared with 5·7 per cent for non-operative observation, P < 0·001; odds ratio 1·88, 95 per cent c.i. 1·50 to 2·36), as well as more inpatient hospital days for diverticulitis-related admissions (mean 8·0 versus 4·6 days respectively, P < 0·001; incidence rate ratio (IRR) 2·16, 95 per cent c.i. 1·89 to 2·47) and higher mean diverticulitis-related cost (€70 107 versus €24 490, P < 0·001; IRR 3·11, 2·42 to 4·01).

Conclusion

Observation without elective colectomy following resolution of an initial diverticular abscess is a reasonable option with lower healthcare costs than operation.
Lacosamide on background eeg activity in brain tumor‐related epilepsy patients: A case series study
Authors: Maschio Marta , Zarabla Alessia , Maialetti Andrea , Sperati Francesca , Dinapoli Loredana , Dispenza Sabrina , Petreri Gianluca , Cantelmi Tonino
Published: October 2018

Objective

Therapeutic doses of antiepileptic drugs (AEDs) may alter EEG background activity, which is considered an index of the functional state of the brain. Quantitative analysis (qEEG) of EEG background activity is a valid instrument to assess the effects of many centrally active drugs on the central nervous system, including AEDs. Lacosamide (LCM) is a new AED that could be a valid therapeutic choice in patients with brain tumor‐related epilepsy (BTRE).

Methods

We used qEEG to analyze the possible effect of LCM as an add‐on, on background EEG activity after 4 months in patients with BTRE.

Results

We consecutively recruited sixteen patients with BTRE: Five dropped out for disease progression, five for scarce compliance, and six completed the study. For these reasons qEEG was performed at first visit and after 4 months only in six patients. For all frequency bands, LCM revealed no changes of mean relative power during rest with eyes closed, hyperpnoea (HP), and mental arithmetic task (MA); significant increment was found only in the theta mean relative power during opening and closing eyes (BR). After four months of therapy with LCM, one patient was seizure free, four had a seizure reduction ≥50%, and one showed a worsening in seizure frequency <50%.

Conclusion

Despite the limitation of a small series, these findings suggest that LCM seems to have only a mild interference on EEG background activity and confirm that LCM has a good efficacy on seizure control in patients with BTRE. This is the first study that evaluates the effect of LCM on background EEG activity, using qEEG in BTRE patients. Future research in this area could include prospective studies with qEEG for a longer follow‐up period to assess the impact of AEDs on brain functions in this particular fragile patient population.
Antimicrobial Homoisoflavonoids from the Rhizomes of Polygonatum verticillatum
Authors: Sharma Shruti , Patial Vijeta , Singh Dharam , Sharma Upendra , Kumar Dinesh
Published: October 2018

Three homoisoflavonoids, including a new compound, 5,7‐dihydroxy‐3‐(4‐methoxybenzyl)‐8‐methyl chroman‐4‐one (1), together with two known compounds, 5,7‐dihydroxy‐3‐(2‐hydroxy‐4‐methoxybenzyl)‐8‐methylchroman‐4‐one (2) and 5,7‐dihydroxy‐3‐(2‐hydroxy‐4‐methoxybenzyl)‐chroman‐4‐one (3), were isolated from the rhizomes of Polygonatum verticillatum (L.) All. (P. verticillatum). Isolated compounds were characterized on the basis of UV, FT‐IR, ESI‐MS, and 1D‐, 2D‐NMR data. Further, different extract fractions and pure compounds from Polygonatum verticillatum were screened for their antimicrobial potential. Among three pure compounds, compound 2 was found most potent with good zone of microbial growth inhibition as compared to the standards.
Successful institutional care for behavioral and psychological symptoms of dementia in a repopulated area after the 2011 Fukushima disaster: A case report
Authors: Nishikawa Yoshitaka , Niimura Hidehito , Ozaki Akihiko , Kimura Yuko , Morita Tomohiro , Sawano Toyoaki , Saito Hiroaki , Tsubokura Masaharu
Published: October 2018

Key Clinical Message

Caregiving in a long‐term facility played a key role in improvements of this patient's behavioral and psychological symptoms of dementia, which also led to a reduced caregiver burden on her family members. Considering the global population aging trend, the lesson from this case may apply to other settings beyond disasters.
Environmentally Benign Arylations of 5‐Membered Ring Heteroarenes by Pd‐Catalyzed C−H Bonds Activations
Authors: Mao Shuxin , Li Haoran , Shi Xinzhe , Soulé Jean‐François , Doucet Henri
Published: October 2018

The palladium‐catalyzed functionalization of 5‐membered ring heteroaromatics, through a C−H bonds activation, for access to arylated heteroaromatics represent a very attractive alternative to more classical cross‐coupling reactions, as it saves steps and reduces the amount of wastes. Despite these advantages, these transformations initially suffered from major limitations in terms of sustainable chemistry concerning the reaction media, the nature of the catalyst, the catalyst loading, the aryl source or the regioselectivity control. Tremendous improvements allowing more sustainable reaction conditions using greener solvents, new aryl sources or employing easily removable catalysts and lower catalyst loadings have been described during the last decades. This review summarizes some of the most important contributions made in these directions.
Triindolo‐Truxene Derivatives: Design, Synthesis, and Fine‐Tuning of Electronic Properties and Molecular Assembly through Molecular Engineering
Authors: Chen Jun‐Bo , Zhou Cen , Lu Ru‐Qiang , Wang Xin‐Chang , Qu Hang , Saha Mithu , Liu Hao‐Liang , Zhang Hui , Cao Xiao‐Yu
Published: October 2018

Triindolo‐truxene, a C3‐symmetric molecule with a large π‐conjugated plane, has six methylene carbon atoms and three aromatic carbon atoms that can be facilely functionalized. Herein, butyl, carbonyl, cyano, and/or malononitrile groups were introduced at six methylene carbon atoms (6‐, 14‐, 22‐ or 8‐, 16‐, 24‐positions) and/or three aromatic carbon atoms (2‐, 10‐, and 18‐positions) of triindolo‐truxene to produce eight derivatives. Their photophysical properties, electrochemical properties, and molecular assembly can be effectively modulated by substituents and substitution patterns. Incorporation of electron‐deficient groups led to redshifts in both the absorption and emission of these derivatives and also lowered their HOMO and LUMO levels. Different substitution patterns resulted in the different intramolecular donor–acceptor interactions. Electron‐deficient substituents at the methylene carbon atoms in the 6‐, 14‐, and 22‐positions led to intramolecular charge transfer from the fluorene arms to the truxene core, whereas the corresponding substitutions at the methylene carbon atoms in the 8‐, 16‐, and 24‐positions resulted in intramolecular charge transfer from the truxene core to the fluorene arms. The molecular packing in single crystals and molecular aggregation in solution are also influenced by the substituents and substitution patterns. This work provides a straightforward strategy to alter the properties of triindolo‐truxene.
Future Perspectives: Using Computer Simulations to Supplement Students’ Introduction to Scientific Inquiry
Authors: Stamer Insa , Beiroth Femke , Schwarzer Stefan , Hartke Bernd , Lindhorst Thisbe K. , Parchmann Ilka
Published: October 2018

In der Chemie ist die Synthese von chemischen Verbindungen im Labor ein zentraler Aspekt, wenngleich dieser häufig langwierig und kostspielig ist. Dank immer leistungsfähigerer Computer und immer besserer Software und Algorithmen werden Moleküle längst nicht mehr nur praktisch‐experimentell untersucht. Es können beispielsweise Eigenschaften, Bewegungen und Reaktionen am Computer simuliert und vorausgesagt werden. Die theoretische Chemie ist somit ein unverzichtbares Teilgebiet der Chemie. In diesem Artikel wird ein Versuch vorgestellt, der die Simulation von Molekülen in der Schule und im Chemiestudium ermöglicht. Als konkretes Beispiel werden Moleküle untersucht, die das Anhaften von E. coli‐Bakterien an menschliche Zellen verhindern können. Diese Forschung zielt darauf ab, Krankheiten wie Nierenbeckenentzündungen ohne Einsatz von Antibiotika erfolgreich zu therapieren.
Subtyping salivary gland neoplasm of uncertain malignant potential based on cell type demonstrates differential risk of malignancy
Authors: Hang Jen‐Fan , Alruwaii Fatimah , Zeng Bao‐Rung , Lai Chiung‐Ru , Wu Howard H.
Published: October 2018

BACKGROUND

The newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine‐needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but cannot be further designated as a specific tumor type. The objective of the current study was to evaluate the clinical utility of subtyping SUMP cases based on different cell types.

METHODS

A retrospective search of cytology databases at 2 institutions for salivary gland FNAs from 2006 through 2017 was conducted. The cytologic diagnosis of each case was reclassified according to the MSRSGC. Histologic follow‐up was retrieved for correlation. Cases reclassified as SUMP that had a follow‐up pathologic diagnosis were subject to cytology review and subtyping into oncocytic/squamoid, basaloid, or myoepithelial subtypes based on cytomorphology. The risk of malignancy (ROM) for each subtype was analyzed.

RESULTS

There were 92 SUMP cases, which comprised 5.9% of 1560 consecutive salivary gland FNAs within the 12‐year study period. Histologic follow‐up was available for 59 patients. After cytology review, there were 18 cases (30.5%) of oncocytic/squamoid subtype, 25 (42.4%) of basaloid subtype, and 16 (27.1%) of myoepithelial subtype. Pathologic correlation revealed an ROM of 61.1% (11 of 18 cases) for the oncocytic/squamoid subtype, 40.0% (10 of 25 cases) for the basaloid subtype, and 18.8% (3 of 16 cases) for the myoepithelial subtype. The differences in ROM among the 3 subtypes were statistically significant (P = .0476).

CONCLUSIONS

Subtyping SUMP cases into categories based on cell type demonstrated differential ROMs for better clinical stratification. Future prospective studies are mandatory to confirm this finding.
Copper‐Nanocluster‐Based Transparent Ultraviolet‐Shielding Polymer Films
Authors: Shi Yu‐e , Zhuang Xuming , Cao Lili , Gou Siyu , Xiong Yuan , Lai Wing‐Fu , Wang Zhenguang , Rogach Andrey L.
Published: October 2018

Transparent, utraviolet (UV) shielding composite materials, which combine the polymer matrix and organic or inorganic UV absorbers, are attractive for packaging industry. Many of these composite films are still suffering from several issues, such as low stability, toxicity of the UV absorbers, and light scattering caused by aggregation. We introduce UV shielding films fabricated by using copper nanoclusters embedded in the polymer framework of the cross‐linked polyvinyl alcohol and polyvinylpyrrolidone. Such composite films show a high UV shielding ability, and allow for transmittance of light in the visible range; they possess favourable mechanical properties (flexibility), thermal stability, and stability against UV light exposure. Potential applicability of the films is demonstrated through protection of Rhodamine B dye from photodegradation.
Primary breast lymphoma: A single‐centre experience
Authors: Foo Mang Yik , Lee Wai Peng , Seah Chin Mui Jaime , Kam Carmen , Tan Su‐Ming
Published: October 2018

Background

Primary non‐Hodgkin lymphoma is an extremely rare entity, and this condition represents less than 0.5% of all malignant lesions involving the mammary gland. As such, there has been a paucity of relevant clinical data arising from Southeast Asia.

Aims

Our study aims to review the clinical presentation, diagnostic methods, treatment, and survival outcomes of all patients diagnosed with primary breast lymphoma in our institution between 2011 and 2017.

Methods and results

Patients who had histologically proven lymphoma involving the breast were identified from a prospectively collected database in a single institution between 2011 and 2017. All seven patients were female, with a median age of 65 years old, and had presented with unilateral large breast or axillary masses. All the histological diagnosis was achieved with adequate tissue diagnosis either through core, incisional, or excisional biopsy. Five patients had diffuse large B cell lymphoma, one had marginal zone lymphoma, and the other had follicular lymphoma. Based on Ann Arbor classification, one patient had stage 1, three had stage 2, one with stage 3, and two patients with stage 4 disease. Five patients had received standard CHOP regimen with rituximab. At the time of analysis, patients who had nondisseminated disease had a median survival of 57 months. The overall mean survival time for all seven patients was 47 months. With the standard systemic chemotherapy treatment regimen, the estimated 3‐year overall survival was found to be 64%.

Conclusion

Primary breast lymphoma, though uncommon, may present in a similar manner as breast carcinomas, but the main treatment modality remains nonsurgical with systemic chemotherapy. Hence, it is prudent to obtain accurate histological diagnosis of primary breast lymphoma. In this study, our patients with nondisseminated breast lymphoma have demonstrated a fairly good survival outcome following chemotherapy.
K‐M theory of fabric knitted by three‐channel rotor spun wool yarn
Authors: Yang Ruihua , Xu Yaya , Deng Qianqian , Xie Chunping , Gao Weidong
Published: October 2018

Two‐component and three‐component color blended yarns were spun by red, yellow, and blue wool slivers using a three‐channel rotor spun machine, and the corresponding plain fabrics were knitted. The color‐matching models of K‐M theory were built with the relative method and the least squares method, respectively. Colors and blending ratios of the fabrics were predicted by the model. The results showed that the average color differences of the samples predicted by the two methods are both about 1.0 and the mean value of the proportional error is below 3%. The least squares method has a better color‐matching effect for the three‐component sample, and the relative value method has better color‐matching results for the two‐component sample. When the tolerance range is 2.0, the pass rates of the samples predicted by either the relative value method or the least squares method reach 100%.
Analysis on profit model of multi‐information products logistics using evolutionary game algorithm
Authors: Yang Bo
Published: October 2018

Agricultural products logistics finance warehouse business mainly includes three parties: agricultural production and processing enterprises and the third‐party logistics enterprises and financial institutions, to allow three parties to achieve a win‐win situation; in this paper, the evolutionary game theory is used to construct the evolutionary game model of three‐party selection different strategies and, through the construction of replicated dynamic equation, solving the evolution stable strategy. At last, based on the evolutionary stable point, the paper analyzes the strategies of agricultural production and processing enterprises, the third‐party logistics enterprises and financial institutions, and gives the feasible suggestions to the three‐party strategy. Realization of agricultural products logistics finance warehouse profit model three‐party mutual benefit and win‐win, so as to promote the smooth development of agricultural products logistics financial business, ensure the cooperation and common development of agricultural production and processing enterprises and the third‐party logistics enterprises.
Attribute importance measurement based on the data effect and its performance analysis in computation practice
Authors: Li Fachao , Jin Chenxia , Zhang Xiao
Published: October 2018

Attribute importance measurement is the core of multi‐attribute decision making. This study aims at resolving the problem of attribute importance computation. Based on the data system and the inclusion degree of sets, we propose a data deletion method based on knowledge reliability. By taking the hidden knowledge in the data system as the carrier, we further discuss the changing rules of knowledge factors in the subsystems and propose an attribute importance measurement method based on the data effect (abbreviated DE‐AIM). Furthermore, we analyze the values and structure features of DE‐AIM through a theoretical proof and an example calculation. Finally, we compare DE‐AIM with other attribute importance measurements by combining with concrete cases and several data sets from UCI. All the results indicate that DE‐AIM not only has good structural features and interpretability but also can reflect different decision preference by changing parameters. The method has wide applications in many fields such as resource management, artificial intelligence, complex system optimization, expert systems, and concurrency computation.
Scanning Fluorescence Correlation Spectroscopy for Quantification of the Dynamics and Interactions in Tube Organelles of Living Cells
Authors: Unsay Joseph D. , Murad Fabronia , Hermann Eduard , Ries Jonas , García‐Sáez Ana J.
Published: October 2018

Single‐molecule spectroscopic quantification of protein‐protein interactions directly in the organelles of living cells is highly desirable but remains challenging. Bulk methods, such as Förster resonance energy transfer (FRET), currently only give a relative quantification of the strength of protein‐protein interactions. Here, we introduce tube scanning fluorescence cross‐correlation spectroscopy (tubeSFCCS) for the absolute quantification of diffusion and complex formation of fluorescently labeled molecules in the mitochondrial compartments. We determined the extent of association between the apoptosis regulators Bcl‐xL and tBid at the mitochondrial outer membrane of living cells and discovered that practically all mitochondria‐bound Bcl‐xL and tBid are associated with each other, in contrast to undetectable association in the cytosol. Furthermore, we show further applicability of our method to other mitochondrial proteins, as well as to proteins in the endoplasmic reticulum (ER) membrane.
Tuning the Porosity and Photocatalytic Performance of Triazine‐Based Graphdiyne Polymers through Polymorphism
Authors: Schwarz Dana , Acharjya Amitava , Ichangi Arun , Kochergin Yaroslav S. , Lyu Pengbo , Opanasenko Maksym V. , Tarábek Ján , Vacek Chocholoušová Jana , Vacek Jaroslav , Schmidt Johannes , Čejka Jiří , Nachtigall Petr , Thomas Arne , Bojdys Michael J.
Published: October 2018

Crystalline and amorphous organic materials are an emergent class of heterogeneous photocatalysts for the generation of hydrogen from water, but a direct correlation between their structures and the resulting properties has not been achieved so far. To make a meaningful comparison between structurally different, yet chemically similar porous polymers, two porous polymorphs of a triazine‐based graphdiyne (TzG) framework are synthesized by a simple, one‐pot homocoupling polymerization reaction using as catalysts CuI for TzGCu and PdII/CuI for TzGPd/Cu. The polymers form through irreversible coupling reactions and give rise to a crystalline (TzGCu) and an amorphous (TzGPd/Cu) polymorph. Notably, the crystalline and amorphous polymorphs are narrow‐gap semiconductors with permanent surface areas of 660 m2 g−1 and 392 m2 g−1, respectively. Hence, both polymers are ideal heterogeneous photocatalysts for water splitting with some of the highest hydrogen evolution rates reported to date (up to 972 μmol h−1 g−1 with and 276 μmol h−1 g−1 without Pt cocatalyst). Crystalline order is found to improve delocalization, whereas the amorphous polymorph requires a cocatalyst for efficient charge transfer. This will need to be considered in future rational design of polymer catalysts and organic electronics.
Heterostructured d‐Ti3C2/TiO2/g‐C3N4 Nanocomposites with Enhanced Visible‐Light Photocatalytic Hydrogen Production Activity
Authors: Zhang Mengyuan , Qin Jiaqian , Rajendran Saravanan , Zhang Xinyu , Liu Riping
Published: October 2018

The construction of a 2D–2D heterostructured composite is an efficient method to improve the photocatalytic hydrogen generation capability under visible light. In this work, simple heat treatment of a mixture of g‐C3N4 and delaminated Ti3C2 was used to prepare a series of d‐Ti3C2/TiO2/g‐C3N4 nanocomposites. The d‐Ti3C2 not only acted as the support layer and resource to glue the anatase TiO2 particles and g‐C3N4 layers together but also served as the fast electron transfer channel to improve the photogenerated charge carriers’ separation efficiency. By tuning the g‐C3N4/d‐Ti3C2 mass ratio, heating temperature and soaking time, the d‐Ti3C2/TiO2/g‐C3N4 nanocomposite 4‐1‐350‐1 achieved an excellent H2 evolution rate of 1.62 mmol h−1 g−1 driven by a 300 W Xe lamp with a 420 nm cutoff filter. The heterostructured composite photocatalyst was stable even after 3 cycles, representing excellent potential for the practical application in solar energy conversion.
Quantification and phenotypic characterization of peripheral blood Vδ1 + T cells in chronic lymphocytic leukemia and monoclonal B cell lymphocytosis
Authors: Simões Catarina , Silva Isabel , Carvalho Anabela , Silva Sandra , Santos Susana , Marques Gilberto , Ribeiro André , Roque Adriana , Carda José , Sarmento‐Ribeiro A.B. , Domingues Maria do Rosário , Ribeiro Letícia , Paiva Artur
Published: October 2018

Background

Vδ1+ T cells, a subset of γδ T cells, are responsible for innate‐like immune responses. Recently, an anti‐tumor function mediated by MHC‐unrestricted recognition of lipid and stress molecules, has also been described in these cells. This study aimed to quantify and phenotypically characterize circulating Vδ1+ T cells in B cell Chronic Lymphocytic Leukemia (CLL) and Monoclonal B cell lymphocytosis (MBL).

Methods

This study enrolled 58 individuals distributed in five groups: Binet B and C CLL (n = 9), Binet A CLL (n = 26), High count‐MBL (n = 10), Low count‐MBL (n = 5), and a control group (n = 8). The phenotypic characterization of Vδ1+ T cells, as well as the other T cell subpopulations (CD4+, CD8+, CD4+/CD8+, and Vδ1− γδT cells), were assessed by flow cytometry, evaluating the frequency of each subset expressing CD27, CD69, and cytoplasmic granzyme B.

Results

We observed an increasing percentage of Vδ1+ T cells belonging to CD27− compartment from controls to advanced stages of the disease, which was accompanied by an increasing percentage of these cells expressing granzyme B, a phenotypic pattern that was also observed in the other T cell subpopulations under study since earlier stages of the disease. Moreover, a striking expansion of Vδ1+ T cells in Binet B and C CLL was observed.

Conclusions

These experiment findings point to an expansion of CD27‐Vδ1+ T cells with a cytotoxic profile, from controls to advanced stages of the disease, which points to a role of Vδ1+ T cells in the host's anti‐tumor responses against clonal B‐cells in MBL and CLL. © 2018 Clinical Cytometry Society
Design health care facilities to reduce stress, anxiety
Authors: Sutton Halley
Published: October 2018

NASHVILLE, Tenn. — Cultivating whole‐student wellness starts the minute students set foot on your campus. And students who are healthy both mentally and physically typically do better. “Many universities recognize that student health issues are directly related to student retention and student achievement,” said Deborah Beck, Ed.D., executive director of student health services and Healthy Carolina at the University of South Carolina.
Why we need specialization in health science disability services
Authors: Haverstick Jean
Published: October 2018

For 10 years, I have worked with the University of Vermont's Larner College of Medicine. Throughout this time, I tried many approaches to advocating for and accommodating students but was unfamiliar with the nuances of the curriculum. With only a handful of students per year, none requesting clinical accommodations, I also had limited opportunity to engage with the LCOM administrators.
Facile Synthesis of Porous Ternary MnTiO3/TiO2/C Composite with Enhanced Electrochemical Performance as Anode Materials for Lithium Ion Batteries
Authors: Gou Qianzhi , Li Chao , Zhang Xueqi , Zhang Bo , Huang Deyu , Lei Caixia
Published: October 2018

A unique porous ternary MnTiO3/TiO2/C composite is obtained from Mn2O3/polyaniline precursor through the liquid phase deposition (LPD) method and subsequent carbonization process. When the MnTiO3/TiO2/C composite is evaluated as anode materials for lithium ion batteries (LIBs), it displays enhanced electrochemical performance, including superior cycling stability (418 mAh g−1 after 200 cycles at 500 mA g−1), favorable rate capability (270 mAh g−1 at 4 A g−1), and supernal coulombic efficiency (>98% after 200 cycles), compared with pristine Mn2O3 and Mn2O3/TiO2 composite. The enhanced electrochemical performance of ternary composite is mainly ascribed to the unique structural design and the synergistic effect of various components. Therefore, the resultant porous ternary MnTiO3/TiO2/C composite would have great potential as a new generation of anode materials for LIBs.
Energy Analysis of Fuel Cell Electric Vehicles (FCEVs) under European Weather Conditions and Various Driving Behaviors
Authors: Hollweck B. , Moullion M. , Christ M. , Kolls G. , Wind J.
Published: October 2018

Due to the auxiliary loads' increasing influence on the overall energy consumption of electrified vehicles, a holistic tank‐to‐wheel analysis is necessary. To do so, the impact of the auxiliary load on the energy consumption of a fuel cell electric vehicle (FCEV) drivetrain is investigated by taking different driving behaviors and three European environmental conditions (Spanish, German and Norwegian weather profiles) into account. The driving pattern is analyzed with the study ‘Mobilität in Deutschland' [1] and represented with the Artemis driving cycles [2]. To match various situations of the everyday life, realistic boundary conditions are determined by five starting times. The corresponding weather conditions are obtained and five weather profiles for every meteorological season including the ambient temperature, solar flux and humidity are considered. By using a complete FCEV simulation model, a realistic energy consumptions is simulated and the impact of different climate conditions as well as driving behaviors is investigated. As a result, a significant influence of the auxiliary load on the overall energy consumption is detected and the need to consider the overall energy demand is demonstrated.
Electric‐Sector Transformation Requires New Advancements in System Resource Planning
Authors: Diamant Adam
Published: October 2018

In recent years, the electric power industry has been undergoing a dramatic transformation driven by a variety of factors, including rapid deployment of large‐scale variable renewable resources (VERs) and distributed energy resources (DERs); dramatic advances in digital energy and communications technologies that spur increasing customer choice and control; persistent low natural gas prices and increased reliance on just‐in‐time delivery of natural gas to support gas‐fired generation; increased awareness of potential high‐impact, low‐frequency events that may disrupt electricity service over wide areas; and growing awareness of the electric sector's potential role in achieving environmental and other broad, societal goals.
Compositions and Structures of Zeolitic Imidazolate Frameworks
Authors: Noh Kyungkyou , Lee Jisu , Kim Jaheon
Published: October 2018

Zeolitic imidazolate frameworks (ZIFs), which are composed of point metal centres and imidazolate linkers, can adopt numerous three‐dimensional structures. Their unique structures and porosity properties make ZIFs promising materials especially for gas separation applications. Recently their unusual phase transition properties are getting research attention rapidly. Indeed, all the properties of ZIFs are dependent on their structures. Although some empirical rules are known for discovering new ZIFs, still scientific intuition and trials are necessary to find proper reaction conditions. Also, practical information should be extracted from the accumulate achievements and in turn, applied to further exploration. In this regard, this article analyses the structures, compositions, and porosity of known ZIFs, where the relationship between imidazolates and topologies is described in detail.