bluuebunny/crossref_metadata_2025 huggingface dataset:
Transperineal Ultrasound Guided-Template Biopsy of Prostate as First Means of Diagnosis of Prostate Cancer One single centre experience on 405 cases
Authors: Scarneciu Ioan , Scarneciu Camelia Cornelia , Banuta Alexandru , Anastasiu Costin Vlad , Todea-Moga Ciprian , Martha Orsolya , Ghirca Veronica , Porav-Hodade Daniel , Maxim Laurian
Published: January 2020

Even if today�s standard procedure for diagnosis of prostate cancer is transrectal ultrasound guided prostate biopsy ( TRB), transperineal ultrasound -guided template biopsy (TPTB) is a safe procedure because the infectious complication have been increasing, with a detection ratio even better than TRB. We consider that TPTB can be the gold standard biopsy. To assess the efficiency and safety of transperineal ultrasound-guided template biopsy of prostate (TPTB). We studied prospectively a number of 405 patients who underwent TPTB of prostate as first means of diagnosis from September 2015 to August 2017.The procedure was performed in the surgery room, in lithotomy positon, under local anesthesia, by means of standard freehand method sampling of at least 12 fragments,based on predetermined mapping. The data base included the age of the patient, the PSA level, the prostatic volume, the presence of clinical suspicion at digital rectal examination, the histopathological data and immediate and late post-surgery complications. Prostate cancer was diagnosed in 68.6 % of men ( median PSA level was 11 ng/mL). A higher detection ratio within patients with prostate volume [ 60 mL can be noticed.The average Gleason score was of 7.6. No patient developed any feverish symptom or urosepsis. Given the increasing trend of sepsis ratio as a result of transrectal biopsy of prostate, as well as the increased ratio of antibiotic resistance, we appreciate that the benefit of transperineal approach is important enough in order to perform TPTB as first means as well as routine for all patients. In this report we looked to assess the efficiency and the safety of TPTB as first mean of diagnosis. None of the patients had a previous biopsy by transrectal or transperineal method.
Bisphosphonates Influence and Pain Assessment in Mobilization of Patients with Fragility Fracture of the Pelvis
Authors: Filip Alexandru , Veliceasa Bogdan , Puha Bogdan , Filip Cristiana , Popescu Dragos , Alexa Ovidiu
Published: January 2020

Fragility fractures of the pelvis have lately gained interest due to the increased incidence caused by aging populations. The aim of the study was to evaluate the results of the therapy in patients with pelvic fragility fracture admitted between January 2015 and September 2018 St. Spiridon Emergency Hospital in Iasi in order to improve the therapeutic approach. We assessed the correlation between pain and the early mobilization under the weight bearing condition in patients with and without osteoporotic therapy in history. The study emphasizes the role of pain in recovery process and underline the serious consequences of the late detection of bone fragility. Our study had revealed that previous osteoporotic treatment has benefits in the event of a fracture. As a result of this analysis, we consider that the age for the prophylactic measures in bone fragility should go below 60 years.
Microstructural Characterization of Some Turbine Blade Martensitic Stainless Steels
Authors: Berbecaru Andrei Constantin , Coman George , Gradinaru Catalin Stefan , Sohaciu Mirela Gabriela , Predescu Cristian , Dumitrescu Ruxandra Elena , Ciuca Sorin , Gherghescu Ioana Arina
Published: January 2020

The paper presents microstructural features of three stainless steels utilized in making hydropower turbine parts. Two of these steels were already used in producing these parts, the third one is newly conceived. Aiming better mechanical and corrosion resistance characteristics, steels were produced using an induction furnace with cold crucible under vacuum and argon atmosphere, striving for an inclusion � free state. Quenching and tempering heat treatments were subsequently applied. The microstructural investigations, carried-out by microhardess testing, optical and scanning electron microscopy (SEM) associated with energy dispersive spectrometry (EDS), were able to explain the structural modifications. Refined microstructures were found in the two first steels. Concerning the third one, a precipitation phenomenon of intermetallic compounds such as Ni3(Ti,Mo) was reported, similar to that encountered in the maraging steels class. Mechanical properties of this steel are very different from classic martensitic stainless steels ones. Specifically, after tempering the hardness values do not decrease as in other steels, but increase about 1.6 times. Thus a new steel category with duplex properties is reported.
Evaluation of Antioxidant and Antimicrobial Activity in Relation to Total Phenolic Content of Green Algae from Black Sea
Authors: Sirbu Rodica , Stanciu Gabriela , Tomescu Aneta , Ionescu Ana Maria , Cadar Emin
Published: January 2020

Worldwide, marine algae are known to produce a wide variety of bioactive secondary metabolites and several compounds have been derived from them for the prospective development of novel drugs by the pharmaceutical industry. In this context, Ulva lactuca, Enteromorpha intestinales, and Cladophora vagabunda, isolated from Black Sea coastal waters of Romania, were evaluated for their potential for bioactivity. Extracts of the algae selected for the study were prepared using ethanol. The study presents original results concerning the total phenolic content (TPC), determined by the spectrometric method (Folin-Ciocalteu method) and the individual phenols from each species of seaweed studied were identified by HPLC-DAD techniques. Total antioxidant activity (ACL) was studied by photochemiluminescence method, and antibacterial activity was studied on two strains of bacteria, Escherichia coli ATCC 10536 - gram-negative and Staphylococcus aureus ATCC 6538P - gram-positive. Results indicated that the highest total phenolic content was obtained for Cladophora vagabunda (325.8 mg/100 g f.w.), followed by Ulva lactuca (285.5 mg/100 g f.w.) and the lowest rate was registered by Enteromorpha intestinalis (268.8 mg/100 g f.w.). Through HPLC-DAD techniques, 6 individual phenolic compounds were identified in all analyzed seaweeds. In addition, two other phenolic compounds were identified in lower concentrations in Ulva lactuca, but only one phenolic compound in Enteromorpha intestinalis. The results of this study show that there is a strong correlation between antioxidant activity (ACL), antibacterial activity and total phenolic content (TPC). Antioxidant activity shows the same order as total phenolic content (TPC): Cladophora vagabunda (64.15 nmol/g sample) followed by Ulva lactuca (22.8 nmol/g sample) and Enteromorpha intestinalis (10.4 nmol/g sample). The antibacterial activity recorded in all green seaweeds shows that the inhibition sites are higher on Escherichia coli compared to Staphylococcus aureus.
Determination of Platelet Parameters with Impedance Automated Analyzers in Diabetic Patients with Coronary Artery Disease
Authors: Apavaloaie (Vladeanu) Maria-Cristina , Bojan Iris Bararu , Badulescu Oana Viola , Plesoianu Carmen Elena , Jitaru Daniela , Bojan Andrei , Iliescu Dan , Sirbu Paul-Dan , Ciocoiu Manuela , Badescu Magda , Arsenescu Georgescu Catalina
Published: January 2020

Atherosclerosis and platelet activity are two important chain factors linked together in the onset and the severity of coronary artery disease. Our study included 60 diabetic patients with ischemic heart disease, all having underwent coronary angiography. In this substudy from a larger epigenetical and genetical study, we phocused on the interrelationship between vessel disease and primary hemostasis. The haematological parameters included were platelet count (PLT), the platelet distribution width (PDW), the mean platelet volume (MPV) and the platelet larger cell ratio (P-LCR). ). The severity of the coronary disease was defined by the number of stenotic/occluded coronary arteries. We demonstrated a positive corelation with the duration of diabetes (p=0.032), as 34% of the patients with a long duration of the diabetes had a higher number of platelets. The mean platelet volume was slightly elevated in diabetic females over 65 years old, compared to younger diabetic men, though not statistically significant (p=0.101). Although the investigated parameters were mostly in the normal range, the fact that for some cathegories of patients they were orientated towards the upper limit, raises some questions for the next studies. Future adjustments of lot number and selection criteria for the following studies are needed. Using the MPV as a prediction test for cardiovascular complications is still a controversial subject, since the scientifical background contains both positive and negative studies on this matter.
Comparison Between Characteristics of Products With Ecolabel and the Ones Without Ecolabel
Authors: Temea Antonina , Nedeff Valentin , Panainte-Lehadus Mirela , Tomozei Claudia
Published: January 2020

The main objective of this paper is to analyze and compare the characteristics of eco-labeled products (energy consumption, CO2, annual operation cost, price difference, payback period) versus the unlabeled products from category electrical and electronic products. The work synthetically presented some of the relevant conclusions of an eco-marketing research in Romania. It is useful for producers and distributors in order to increase their market position and gain competitive advantages.
Synthesis of 2-Pyrrolydinyl-1,3-Dithiolium Derivatives from Propiophenones
Authors: Sarbu Laura Gabriela , Lungu Catalin Neculai , Sandu Ion , Chirita Paul , Bahrin Lucian Gabriel
Published: January 2020

Novel bromo-substituted 4-(2-hydroxyaryl)-5-methyl-2-(pyrrolidin-1-yl)-1,3-dithiol-2-ylium perchlorates have been synthesized by the heterocondensation of the corresponding 1-(2-hydroxyaryl)-1-oxopropan-2-yl dithiocarbamates. The latter compounds have been obtained from the reaction of the corresponding substituted a-bromopropiophenones with pyrrolidinium pyrrolidine-1-carbodithioate. The mesoionic 4-(2-pyrrolidinyl-1,3-dithiol-2-ylium-4-yl)phenolates have been obtained from the corresponding 1,3-dithiolium perchlorates under weak basic conditions. These compounds were characterized by NMR and MS spectrometry, UV-Vis and IR spectroscopy.
Hyperproduction Hydrogenic of STH Patology Generation of Clinical - paraclinical Disorders
Authors: Ionescu Elena , Chirita Anca , Cotoi Bogdan Virgil , Ganescu Anca
Published: January 2020

Pituitary adenomas are benign tumors ; they arise from epithelial pituitary cells and they represent 10-15% of intracranial tumors. They can be found at 3% up to 20% of the population, on autopsy series. Cephalalgia is a precocious symptom which keeps going over the disease. The aspect as a whole of the person who suffers from this disease in the phase of established malady is characteristic: a very flat-shaped body, massive and stubby thus justifying the comparison with a pachyderm. Hands and legs are disproportionally bigger, like paddles, facies is disharmonic, facial features become coarse, with oblate forehead and massive prominent pregnant mandible. The joints disproportionately bigger, have limited, painful movement. The patient also presents visceral hypertrophy with numerous dysfunctions from various apparatus and systems.
The Mutation Profiles of KRAS and BRAF Genes in a Romanian Colorectal Cancer Cohort
Authors: Brinzan Costel , Aschie Mariana , Grasa Catalin Nicolae , Mitroi Anca Florentina , Matei Elena , Cozaru Georgeta Camelia
Published: January 2020

Colorectal cancer (CRC) is one of most commonly diagnosed malignancies and management of CRC differs in according with patient�s characteristics, tumor type, differentiation, metastatic extension and KRAS/BRAF mutations. Based on this knowledge, we examined the relationship between KRAS/BRAF mutations in paraffin-embedded tumor specimens and some clinicopathological features at CRC in order to provide reliable results to the oncologists and so to contribute to the best care provided to the patients. A 56 of colorectal cancer samples were analyzed for the KRAS and BRAF mutational status using StripAssay method from ViennaLab, Austria. Assays for identification of KRAS/BRAF mutations were based on polymerase chain reaction (PCR) and reverse-hybridization. KRAS mutations were present in 50% (28 patients) of all analyzed CRC and were located in codons 12, 13 and 61. The most frequent types of mutations were substitution of glycine to valine in codon 12 (c.35G]T; 9/28), followed by glycine to aspartate on codon 13 (c.38G]A; 5/28). BRAF mutations were detected at 9 patients (16%) and in all cases Val600Glu mutation has been observed. In one case we reported a concomitant KRAS/BRAF mutation. According with current data, KRAS and BRAF mutations are associated with a poor patient prognosis in CRC, but KRAS mutation in codon 13 and BRAF appear to have a higher oncogenic potential.
Ceratonia Siliqua Methanolic Extract on 6-OHDA Zebrafish Model Antiacetylcholinesterase and Anxiolytic Profile
Authors: Hritcu Lucian , Abidar Sara , Dumitru Gabriela , Boiangiu Razvan Stefan , Nhiri Mohamad , Sandu Ion , Todirascu-Ciornea Elena
Published: January 2020

Anxiety and depression are the most common mental disorders that increase morbidity in the world, and recent data (World Health Organization - WHO) show that over 322 million people suffer from depression and anxiety, especially women being more exposed than men. 6-Hydroxydopamine (6-OHDA) is a catecholaminergic neurotoxin which is formed endogenously in patients diagnosed with Parkinson�s disease and has two mechanisms of action. Thus, it easily forms free radicals and is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The treatments administration of 6-OHDA (160 �M) and Ceratonia siliqua L. methanolic extract (0.1 mg/mL, 0.3 mg/mL and 1.0 mg/mL) in Danio rerio specimens affected the acetylcholinesterase activity (AChE) and anxiolytic profile in close correlation with the dose of administered extract, the group with significant differences being the treated one with 6-OHDA alone.
Chemical Composition and Nutritional Evaluation of Pasteurized Egg Melange
Authors: Simeanu Daniel , Nistor Andreea Catalina , Avarvarei Bogdan-Vlad , Boisteanu Paul-Corneliu
Published: January 2020

Egg is a basic foodstuff in many cultures and has a special place, also represent a rich source of nutrients such as, high quality proteins and a large variety of minerals and vitamins. The main derived products which are processed nowadays are dehydrated products (egg powder) and the liquid ones (refrigerated or frozen) as well as pasteurized egg m�lange which was the studied food in the current research. A number of 20 samples of egg m�lange were gathered from two different processing units. Samples were subjected to chemical analysis being determined content in water, dry matter, proteins, lipids, minerals, non-nitrogenous extractive substances, fatty acids and amino acids. Based on the obtained values was realised a nutritional evaluation for the analysed product by calculating the chemical indexes of essential amino acids (CI), essential amino acids index (EAAI), biological value (BV) and nutritional index (NI) for three categories of persons (children, young people and adults). The results of the current study showed the fact that chemically speaking, the analysed pasteurized egg m�lange presented values which were into the limits from literature; the analysed samples contented 75.59% water, 24.41% dry matter, 12.22% protein, 9.71% lipids, 0.99% total minerals, 1.48% non-nitrogenous extractive substances, 12.34 g/100 g content in amino acids (5.5 g/100 g essential amino acids) and 22.86 g/100 g lipids for polyunsaturated fatty acids. After nutritional evaluation of proteins from the studied food we observed that those ones had a very close value (EAA=50.77 g/16 g N) to the one of hen egg albumen (51.2 g/16 g N), value which is considered etalon. Calculus of some foresight indicators for nutritional value of proteins from studied egg m�lange showed the fact that this one could represent a good source of proteins and implicitly of essential amino acids for humans even if in children�s case the values were a little bit lower and two amino acids (tryptophan and leucine) were slightly limiting.
Ante and Postnatal Ultrasound Contribution and Near-infrared Spectroscopy (NIRS) Monitoring in Preterm Newborns with Intrauterine Growth Restriction Under 32 Weeks of Gestation
Authors: Tunescu Mihaela , Olariu Gabriela , Ratiu Adrian , Ilie Constantin
Published: January 2020

IUGR remains an important health problem in developing countries around the world, being one of the major obstetrical syndromes associated with placental defects, but also one of the topical issues of neonatology, and in particular the association between IUGR and prematurity under 32 weeks of gestation. Neonatal morbidity and mortality remain significant and has an important economic impact. The need for more stringent diagnostic criteria remains a problem. The study proposes to follow the time of extraction of a premature pregnancy IUGR with gestation age �32 weeks, taking into account the centralization of bloodflow as well as IH (hypoxic index) during observation, following the immediate consequences on this new category - as well as their prognosis depending on the associated pathology using cerebral serial Doppler ultrasounds and near-infrared spectroscopy (NIRS).
The Presence of Chronic Kidney Disease in Relation to Age and Duration of Diabetes Mellitus
Authors: Vladu Ionela Mihaela , Tenea Cojan Tiberiu Stefanita , Demetrian Alin , Cristea Oana Mariana , Ene Cristina Gabriela , Clenciu Diana
Published: January 2020

Chronic kidney disease (CKD) affects about 10-13% of the general population with a small proportion in the terminal renal disease stage requiring renal replacement therapy or renal transplantation. CKD is the new cause of mortality in the US. CKD�s prevalence increases with age. Diabetes mellitus is responsible for 50% of cases of chronic kidney disease being the most common cause.
Multidisciplinary Approach of a Very Rare Infected Verrucous Carcinoma of the Scrotum
Authors: Raducu Laura , Avino Adelaida , Cozma Cristina-Nicoleta , Nedelea Sorin , Balcangiu-Stroescu Andra-Elena , Tanasescu Maria Daniela , Balan Daniela Gabriela , Timofte Delia , Jecan Cristian-Radu , Ionescu Dorin
Published: January 2020

Verrucous carcinoma of the scrotum is an extremely rare disease and most cases are thought to result from poor hygiene and chronic inflammation. Currently, it has not been well characterized, the etiology, diagnosis and treatment remaining poorly understood. We present the case of a 50-year-old male patient diagnosed with verrucous carcinoma of the right hemiscrotum. Wide surgical excision was performed. Favorable outcomes can be achieved by surgery, even without any adjuvant therapy, but patients should be carefully followed up.
Lectin from Pisum fulvum Seeds as in vitro Anticancer and Apoptotic Gene Regulator
Authors: Yassin Abdelrahman Mohamed , El-Deeb Nehal Mohamed , Elsaid Fahmy Gad , Shati Ali Abdullah , Cioca Gabriela , Tit Delia Mirela , Bungau Simona , Popa Amorin , Hafez Elsayed Elsayed
Published: January 2020

The lectins are non-immune origin carbohydrate-binding proteins. Plant�s lectins are distributed in many species of medicinal plants, family Fabaceae. In this study the safety usage pattern of wild Pisum fulvum lectin was evaluated on different mammalian noncancerous cell types and the anticancer activity was examined on different cancer human cell lines: colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (HepG2), breast cancer cells (MCF7) and laryngeal carcinoma (Hep-2 cells). Moreover, both morphological and molecular evidence of apoptosis have been detected using both acridine orange/ethidium bromide (AO/EB) stain and RT-qPCR. The results revealed that IC50 of the wild lectin on the noncancerous cells ranged from 19.7 to 2.4 �g protein/mL. In addition, lectin was more potent against HepG2 cells than the other used cells, with inhibition percentages ranged from 68.45 to 90.98 and with cancer cell selectivity index ranged 3.5 to 28.14. The treatment showed 67.6% inhibition of BrdU incorporation in the proliferated hepatocellular carcinoma cells. Furthermore, HepG2-lectin treated cells showed obvious nuclear condensation after 48 h of treatment with ability to down-regulate the expression of BCL2 and BAX and to up-regulate the expression of Ikab gene. The results obtained in this research work clearly indicated the Pisum fulvum lectin could be a promising potential anticancer agent.
Comparative Bio-sorption of Cadmium and Nickel Ions from Aqueous Solution onto Fibers of Date Palm using Fluidized Bed Column
Authors: Abod Baker M. , Al-Alawy Ramy Mohamed Jebir , Kamar Firas Hashim , Nechifor Gheorghe
Published: January 2020

The aim of this study is to use the dry fibers of date palm as low-cost biosorbent for the removal of Cd(II), and Ni(II) ions from aqueous solution by fluidized bed column. The effects of many operating conditions such as superficial velocity, static bed height, and initial concentration on the removal efficiency of metal ions were investigated. FTIR analyses clarified that hydroxyl, amine and carboxyl groups could be very effective for bio-sorption of these heavy metal ions. SEM images showed that dry fibers of date palm have a high porosity and that metal ions can be trapped and sorbed into pores. The results show that a bed height of 6 cm, velocity of 1.1Umf and initial concentration for each heavy metal ions of 50 mg/L are most feasible and give high removal efficiency. The fluidized bed reactor was modeled using ideal plug flow and this model was solved numerically by utilizing the MATLAB software for fitting the measured breakthrough results. The breakthrough curves for metal ions gave the order of bio-sorption capacity as follow: Cd(II)]Ni(II).
New (azulen-1-yldiazenyl)-heteroaromatic Compounds Containing 1,2,5-thiadiazol-3-yl Moieties
Authors: Razus Alexandru C. , Birzan Liviu , Cristea Mihaela , Tecuceanu Victorita , Draghici Constantin , Hanganu Anamaria , Maganu Maria , Pintilie Lucia , Ungureanu Eleonora Mihaela
Published: January 2020

(E)-2-(Azulen-1-yldiazenyl)-1,3,4-thiadiazoles, unsubstituted or substituted either at azulen-1-yl moiety or at 5-position of thiadiazole ring were synthesized. Among the acids used as diazotization medium, dichloroacetic acid was the best choice. In several cases the by-products such as thioether 9 were isolated along with the normal coupling derivatives. The generated products were characterized and their MS and UV-vis spectra discussed. A computational study on (E)-2-(azulen-1-yldiazenyl)-1,3,4-thiadiazoles was undertaken based on density functional theory (DFT) to determine frontier orbital energies and other physical properties. The absorption maxima and the basicity of the new compounds are close to those of the corresponding diazenes containing thiazole, previously described. They have brick color in neutral medium and violet in strong acidic solutions. The redox potentials were also determined remarking the influence of the substituents on these potentials.
Relationship Between Intermittent Hypoxia,Nocturnal Voiding and Sleep Related Breathing Disorders
Authors: Otelea Marina Ruxandra , Trenchea Mihaela , Zugravu Corina , Hainarosie Razvan , Rascu Alexandru Stefan , Stefanescu Cristian Dragos
Published: January 2020

Nocturia, cardio-vascular diseases and diabetes are frequent in patients with sleep related breathing disorders. In this study, we had analyzed the influence of the intermittent hypoxia on nocturia prevalence and found that cardio-vascular diseases, obesity, age and apnea hypopnea indexpredict 27.1% of nocturia�s variance (Nagelkerke R square-=.271, c2= 68.35).In AHI [28, the chance of nocturia is 50% and the difference dependents on the presence or absence of the cardio-vascular diseases. For values of AHI ]28, the risk of nocturia becomes independent of the presence of the cardio-vascular disease.
Tetracyclines Residues in Honey
Authors: Dumitriu Buzia Olimpia , Ploscutanu Gabriela , Elisei Alina Mihaela
Published: January 2020

Antibiotic residues have toxic acute and chronic effects on human health and also reduce the efficacy and quality of honey. This review was conducted aiming to evaluate the tetracyclines (TCs) residues in honey, compared to international standards available in this field. In conclusion, our study demonstrated that a worldwide concerted effort is required to uphold the all-natural, wholesome and clean and green image of honey.
A Card Double Face: Compounds Functionality and Synergy of a Topical Treatment Proposed for Oral Health Improvement in Periodontal Disease
Authors: Eftimie Totu Eugenia , Cristache Corina Marilena , Buga Roxana , Dumitru Florina , Totu Tiberiu
Published: January 2020

The application of an active mixture of melatonin, hyaluronic acid and tetracycline, as antibiotic adjuvant, for scaling and root planing in periodontal disease is exploited. The hyaluronic acid gel has been used as matrix for this topical mixture. The mixture of active ingredients has been structurally studied applying UV-Vis and FT-IR spectrophotometry and fluorescence microscopy. Our target was to put in evidence if melatonin, hyaluronic acid and tetracycline were preserving their specific characteristics when they would be mixed together. The recorded results are encouraging as each active compound maintains its characteristic functional groups imparting their biological action. The improved topical treatment based on melatonin, hyaluronic acid and tetracycline is presenting itself as a promising candidate for improving the oral health for patients with periodontitis.
Distribution of Cardiovascular Risk Factors in Patients with Psoriasis
Authors: Stanescu Ana Maria Alexandra , Grajdeanu Ioana Veronica , Serban Bogdan , Diaconu Camelia Cristina
Published: January 2020

Psoriasis is a chronic inflammatory systemic disorder that associates many cardiovascular comorbidities. The association between psoriasis and cardiovascular disease is a complex one, which implies many risk factors, such as age, gender, heredity, smoking, alcohol and stress. The prognosis of patients with psoriasis may be improved by identifying and reduction of these cardiovascular risk factors. The objective of our study was to determine the prevalence of cardiovascular risk factors among patients with psoriasis from Bucharest and Ilfov county, Romania. 634 individuals from the general population were initially included. From these individuals, 208 patients with psoriasis have been selected for inclusion in our observational study. The patients were selected from Elias Emergency Hospital of Bucharest, Romania, and through the family doctors praxis, between 2010-2017. Of the 634 individuals from the general population, 208 patients (33%) were identified as patients with a diagnosis of vulgar psoriasis, confirmed by the dermatologist, forming the study group. The presence of risk factors is consistent with the presence of cardiovascular disease (23%) in the studied group. Patients with psoriasis, without cardiovascular diseases, have an increased risk of developing them throughout their lives. Patients with psoriasis have a very high risk of developing life-long cardiovascular disease, because of a multitude of risk factors associated with psoriasis. Intervention on modifiable risk factors for cardiovascular disease can be mediated by a family doctor, who can monitor the development over time and may also intervene early when appropriate.
A Medium-term Analysis of Wastewater from an Agricultural Area
Authors: Dragomir Balanica Carmelia Mariana , Simionescu Aurel Gabriel , Popa Camelia Lacramioara , Bichescu Cezar-Ionut , Muntenita Cristian
Published: January 2020

Nitrate is ordinarily found within the ecosystem, as part of the nitrogen cycle. The anthropogenic inputs have highly increased nitrate loads into ground and surface waters. All these factors have had a drastic impact on aquatic environment, human health and flora and fauna. Hence, the identification of nitrate sources is valuable in conserving water quality and achieving sustainability of the water resources. The present paper aims to present a clearly image of water pollution in South and South Est part of Romania. The dataset for ammonium (NH4+), total nitrogen (Ntot) and nitrite (NO2-) was collected from 2013 -2017.
The Influence of Digestive Dysfunctions on Quality of Life in Parkinson Disease
Authors: Criciotoiu Oana , Stanca Iulia-Diana , Glavan Daniela-Gabriela , Latea Roxana Mirela , Mita Adrian , Calborean Veronica , Gheorman Victor , Udristoiu Ion , Dijmarescu Anda Lorena , Davitoiu Dragos Virgil , Gheonea Dan Ionut
Published: January 2020

As a part of non-motor symptoms in Parkinson�s disease (PD), the dysfunctions of the gastrointestinal tract are frequent, being a major complain in the majority of the patients. The aim of our study was to assess the impact of digestive dysfunctions on quality of life in Parkinson�s disease. We included in this study 60 patients with PD, with a disease severity which varied between 2 and 5 on Hoehn and Yahr Scale. Our results showed a low correlation between digestive dysfunctions and the severity of the disease, but a statistically significant correlation between quality of life and the stage of the disease. Also, we observed a statistically significant correlation between digestive dysfunctions and quality of life. Our study revealed that the frequency of digestive dysfunction has correlated with a poor quality of life in any stage of the disease.
Nitrous Oxide - a Viable and Modern Alternative for Inhalation Analgesia in Labor
Authors: Tudorache Ioan Sorin , Toader Oana Daniela , Petrescu Eliana , Rusu Elena , Harsovescu Tudor , Voichitoiu Andrei Dennis
Published: January 2020

Pain in labor is an important factor in establishing the prognosis of birth and the quality of the conception product, painful uterine contractions being the main physical and psychological stress factor for the pregnant woman that can be decisive for the birth plan. In the management of labor, individualized analgesic therapy is needed to ensure anesthetic comfort as well as cooperation of the pregnant woman in the last part of labor. Analgesia is not supposed to interfere with the mechanisms that are essential during the expulsion, namely with the intensity and duration of the uterine contraction. The last two decades have consecrated natural birth with controlled pain, which allowed the keeping of a limited incidence of caesarean surgery, attitude recommended by the World Health Organization. However, in Romania the trend towards caesarean births has spiked, including due to little promotion of analgesic techniques for natural birth. One of the most used techniques of analgesia, administration of nitrous oxide - N2O and oxygen - O2 50-50% gaseous mixture represents a viable possibility of pain modulation. Our paper is a descriptive study, examining objective changes of pain perception in a sample of pregnant women with low obstetrical risk, aiming to analyze the quality of analgesia offered by the N2O and O2 50-50% gaseous mixture.
Syntone Chemistry. Theoretical study on the formation of glycine, alannine and serine
Authors: Surpateanu Gheorghe , Nistor Ileana Denisa , Georgescu Ana-Maria , Lungu Neculai Catalin
Published: January 2020

Three synthons: methylene, nitrene and carbon monoxide form aziridinone in the presence of molecular nitrogen at low temperatures. This one, in contact with the same three synthons could form the precursors of the first proteinogenic amino acids. This paper is a theoretical, thermodynamically and reactivity study concerning the formation of the three previously named amino acids at low temperature conditions. The key intermediates are identified in the formation of the three amino acids: aziridinone, aziridinonil and methyl-aziridinonil radicals. The quantitative results, enthalpies of formation, reaction enthalpies and free energies were taken from quantum mechanical calculations acquired by density functional method (DFT): B88-LYP.
Fixed - bed Column Adsorption Studies Using Synthetic Hydroxyapatite for Pb(II) Removal from Aqueous Solutions
Authors: Simonescu Claudia Maria , Tanase Iuliana-Raluca , Purcaru Irina Nicoleta , Tardei Christu , Marinescu Virgil
Published: January 2020

In the present paper, the adsorptive Pb(II) removal from synthetic aqueous solutions using a 2 cm diameter hydroxyapatite column has been studied through column adsorption experiments by varying column depths (1, 2, 3, 4 cm) and flow rate (10, 15, 22.5 mL/min). Different types of synthetic hydroxiapatites have been involved in experiments. Column design parameters such as critical bed depth and adsorption capacity have been determined from experimental studies. The results revealed the effectiveness of synthetic hydroxyapatite porous beads in Pb(II) removal from aqueous synthetic solutions.
Immune Inflammation Related to Obesity in Pregnant Women
Authors: Crauciuc Dragos Valentin , Sindilar Allia , Diac Madalina , Tabian Daniel , David Sofia Mihaela , Bulgaru-Iliescu Diana , Crauciuc Eduard Grabriel
Published: January 2020

Although there are many conditions to be met for the disease to occur (genetic predisposition, environmental factors, stress, exposure to pollutants, noxes, xenobiotics, diet), chronic inflammation is the way how the body responds to these substances. Excess weight leads to an alteration of the immune response, to an increased oxidative stress, and damage to the cellular Deoxyribonucleic acid (DNA) structure. The study aims to evaluate inflammation in obese mothers. The study group consisted of 30 pregnant women in which inflammation was analysed, with a mean age of 30.80 � 6,94 years old divided in 2 groups depending on their weight, that is 25 pregnant women with obesity and 5 normoponderal pregnant women. From the markers found in the blood samples, only CRP (AUC=0.740; IC95%: 0.466-1.014), leptin (AUC=0.616; IC95%: 0.296-0.936) and glycaemia (AUC=0.648; IC95%: 0.369-0.927) were good indicators of immune inflammation. The estimated risk of immune inflammation is 5 times higher in obese pregnancies with CRP levels above 6.
Dopaminergic Centers Neurodegeneration Biochemical and radiologic approach
Authors: Cuciureanu Dan Iulian , Popescu Roxana Mihaela , Cuciureanu Tudor , Constantinescu Victor Alexandru , Hodorog Diana Nicoleta , Szalontay Andreea Silvana
Published: January 2020

Parkinson s disease is the second pathological neurological condition that affects millions of people annually. Up to now there is no curative treatment for this condition. Our study was conducted on a group of 99 patients who were followed periodically, clinically and radiologically for a period of three years after diagnosis with Parkinson�s disease. The results of our study show that MRI examination can be an important tool for differential diagnosis, etiopathogenicity and the prognosis of these patients. Patient follow up is required in personalizing and improving current treatment schedules of Levodopa.
The Triad Nocturia, Smoking and Obstructive Sleep APnea
Authors: Trenchea Mihaela , Arghir Ioan Anton , Popescu Gilda Georgeta , Rascu Stefan , Bechir Edwin Sever , Tofolean Doina Ecaterina , Fildan Ariadna Petronela , Ion Ileana , Dantes Elena
Published: January 2020

In patients with obstructive sleep apnoea (OSA), a consequence of the intermittent hypoxia is nocturia. The frequency of nocturia related OSA is increased because many pathological pathways are present simultaneously. The aim was to assess the prevalence of nocturia among OSA patients and to identify the relationship with OSA and its comorbidities. A transversal study determining the prevalence of OSA�s comorbidities and nocturia related OSA and smoking was assessed, from 2011 to 2015, in 2 Romanian centres of Somnology, in Constanta county. All patients suspected of sleep breathing disorders were investigated by polygraphy and all patients diagnosed with OSA were recruited. Demographic and clinical characteristics were assessed, including the onset of nocturia. The comparison between groups with and without nocturia was performed using SPSS software, using Anova for numerical outcomes and c2 test for the categorical ones. Nocturia was highly prevalent (62.75 %) among 204 OSA patients, especially in elderly (p [ 0.00001). High blood pressure (hypertension), obstructive pulmonary disease (COPD), smoking exposure were more frequently reported in the OSA patients presenting nocturia (p[0.05). Type 2 diabetes and cardiac failure were also frequent, but did not reach a significant threshold of 95%. In conclusion, the nocturia is a frequent symptom and it is influenced by the OSA severity and comorbidities as hypertension and COPD. A further multidisciplinary approach in these patients is justified, especially in smokers.
Thyme Leaves Aqueous Extract and its Formulations. A comparative study based on chemical structures and biological activity
Authors: Proks Maria , Heghes Alina , Cheveresan Adelina , Nita Simona , Voicu Mirela , Buda Valentina , Ionescu Daniela , Nita Lucian , Trandafirescu Cristina , Paunescu Virgil
Published: January 2020

The present study was conducted in order to evaluate the biological activity of thyme aqueous extract as compared to the silver nanoparticles obtained on it on four different cancer lines: non-melanoma skin cancer (A431 cell line), melanoma skin cancer (A375cell line), hormone dependent breast cancer (MCF-7 cell line), and non-hormone dependent breast cancer (MDA-MB-231 cell line). Of particular importance in the study of biological activity is the chemical composition. Formulas rich in compounds of classes like those of flavonoids are recognized for their efficacy and important antioxidant effect. The extract tested at various concentrations ranging from 10-1000 �g/mL exhibited a pronounced effect only on MCF-7 cells at the highest concentration tested and regarding the biosynthesized silver nanoparticles, the effect can be noted even at 1 � M also only in the case of MCF-7 cells.
Effect of 2,6-diisopropylphenol and 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy) propane as Anesthetic
Authors: Lupu Mary-Nicoleta , Miulescu Magdalena , Stefanopol Ioana Anca , Stoleriu Gabriela , Matei Madalina Nicoleta , Manolache Nicuta , Vasincu Decebal , Ciobotaru Oana Roxana , Costuleanu Marcel
Published: January 2020

Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether or C4H3F7O), with a molar mass 200.055 g/mol, also called fluoromethyl, is a highly fluorinated methyl isopropyl ether with general anesthetic property, available for clinical practice for about 30 years. Sevoflurane is a sweet-smelling, non-flammable and it is used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. Propofol (2,6-diisopropylphenol or C12H18O), with a molar mass 178.271g/mol is an alkylphenol derivative formulated for induction and maintenance (in some cases) of general anesthesia, sedation and hypnosis and acting as an intravenous anaesthetic drug, having largely replaced sodium thiopental because recovery from propofol is more rapid and clear.
Rheological Properties and Stability of Dermatocosmetic Emulsions with Collagen and Natural Ingredients Used as Color Correcting Cream and Cream Foundation
Authors: Danila Elena , Kaya Durmus Alpaslan , Ghica Mihaela Violeta , Albu Kaya Madalina Georgiana , Negrea Cristina , Popa Lacramioara , Nitipir Cornelia
Published: January 2020

The aim of this study was to formulate and evaluate two types of O/W emulsions based on collagen and other natural ingredients that can be used as color correcting (CC-cream) and cream foundation. Both types of emulsions obtained are stable at different temperatures and the pH values of emulsions correspond to the natural pH of the skin, indicating that emulsions can be safely applied to the skin. Results from the optical microscopy analysis show that all emulsions present foam-like appearance. The rheological properties of emulsions were studied and it was proved that all emulsions present a non-Newtonian pseudoplastic behaviour and thixotropic characteristics at two operating temperatures (24 and 33�C). It can be concluded that all emulsions can be used as a natural alternative to a CC-cream or a cream foundation. Further microbiological tests and clinical trials are necessary for the obtained emulsions.
Cardio-Pulmonary System Quantum Biological Thermodynamics with Finite Speed of the Cardio-Pulmonary System II - Computation of power and the entropy source of the cardio pulmonary system
Authors: Borcila Bogdan , Petrescu Stoian , Costea Monica , Petrescu Valeria , Bolohan Romi
Published: January 2020

The paper presents the results of the recent studies and research conducted within the Quantum Biological Thermodynamics with Finite Speed on the calculation and interpretation of the Cardio-Pulmonary System performance. Thus, based on the new PV/Px diagram developed for the Cardio-Respiratory System, an original Scheme for calculating the Mechanical Work and Power of the Heart/Lungs has been developed. The new Calculation Scheme allows to study the variation of the Heart and Lungs parameters for each person, in Quantum States and in Processes with and without Quantum Jump. Based on the values calculated in each Stationary State, for the cases studied, the diagrams of the Mechanical Work, of the total Power and the Entropy Source for the Cardio-Pulmonary System, as functions of the Frequencies of the Heart (FH), and the Lungs (FL), the maximum systolic pressure and body mass of the person were thus constructed. The study and interpretation of these diagrams - which are novel elements - provides information on interactions within the Cardio-Pulmonary System or between it and the entire body, particularly useful in bioengineering for optimized and personalized design of artificial organs.
A Binary Distillation Column Top and Bottom Compositions Control Using Two PI Controllers Tuned with SIMC
Authors: Baiesu Alina Simona , Carbureanu Madalina
Published: January 2020

The opportunity analysis of using two Proportional-Integral (PI) controllers, tuned with Skogestad�s variant of Simple Internal Model Control based (SIMC) method, for controlling the top and bottom compositions of a propylene/propane distillation column represents the paper aim. The SIMC method for PID controllers is the simplest and extremely good model in tuning procedures. Because the distillation process is nonlinear, the process model is described by a reunion of different linear models, for the different process operating ranges and, for each operating range, different sets of controllers� tuning parameters are computed using SIMC tuning method. In order to validate the experimental results a comparison is made with the case when the PI controllers are tuned using Ziegler-Nichols (ZN) method that uses the step response and process approximation exactly as Skogestad�s variant of SIMC.
The Role of Chemical Agents in the Microbial Flora with Major Risk of Interventios in Maxilo-facial Surgery
Authors: Stelea Carmen Gabriela , Constantin Iulian , Budacu Cristian , Platon Alexandra Lorina , Balan Mihail , Pavel Liliana , Sirbu Ioan , Luca Mihaela Gabriela , Constantin Mihai
Published: January 2020

The pathology of the oro-maxilo-facial territory comprises a vast chapter of diseases with primary or secondary infectious etiology, the mouth being the natural cavity of the organism with the most varied and variable flora of bacterial contamination. By the continuity solutions created by the mechanical act of mastication, decubitus of defective prosthetic works, local dento-periodontal infectious processes, but especially of dental or small-scale interventions, open gates and possibilities of penetration into the blood circulation of the microorganisms, which cause the transient bacteria. The study included 243 randomly selected patients, with the address of the Oral and Maxillofacial Surgery Clinic in the period 2016-2018. The inoculation of microorganisms in the oral cavity in circulating blood as a result of oral surgery or dental care procedures is much more common than in other areas of the body. Aggressive dental maneuvers that create solutions of continuity of oral mucosa, gingiva, periodontal surgery, periodontal surgery techniques can cause bacteria.
Biochemical and Production of Rhubarb Under Growing Technological Factors
Authors: Cojocaru Alexandru , Munteanu Neculai , Petre Brindusa Alina , Stan Teodor , Teliban Gabriel Ciprian , Vintu Catalin , Stoleru Vasile
Published: January 2020

The aim of the present study was to assess the influence of two varieties of rhubarb (Glanskin�s Perpetual and De Moldova) and two densities, 10.000 and 13.300 pl/ha on the content of macro (K, Ca, P, Mg, Fe and S), micro�elements (Al, Si and Mn), organic acids (tartaric, oxalic, citric, malic and ascorbic) and total production. The content of oxalic acid in the four versions ranged from 2.3 mg/mL juice in the case of Glanskin�s perpetual cultivation, with the density of 13.300 pl/ha at 3.8 mg/mL in the case of the Moldova variety at the same density. The content of tartaric acid varied in wide limits from 1.75 mg/mL juice to 6.5 mg/mL juice. The content of macro-elements varied within wide limits, the report being: Fe ] K ] Mg ]S ] P ] Ca. The largest production was obtained at the variety De Moldova with density of 13.300 pl/ha.
Investigation of Butane-butylene Technical Mixtures Transformation Over Modified Microporous Materials Prepared by Ion Exchange Method Into Liquid Fraction Rich in Aromatic Hydrocarbons
Authors: Asaftei Iuliean Vasile , Lungu Neculai Catalin , Ignat Maria , Sandu Ion
Published: January 2020

The Zn and Ni were introduced into HZSM-5 zeolite by ion exchange method with aqueous solutions of Zn(NO3)2 and Ni(NO3)2, to investigate the catalytic activity and selectivity of modified Zn-HZSM-5 and Ni-HZSM-5 catalysts for conversion of butane-butylenes technical mixtures in a fixed-bed stainless-steel reactor (Twin Reactor System Naky) at 450�C, at atmospheric pressure for Zn-HZSM-5 and at 4 atm. total pressure for Ni-HZSM-5 and at a space velocity (WHSV) of 1h-1. The catalysts were characterized using XRD, SEM, and NH3-TPD analysis for their structure, morphology and acidity. The catalytic activity of the same catalyst were examined during over 10 catalytic tests (with regeneration of catalyst after each test) using mixtures of butanes-butylenes.
Synthesis and Characterization of Hydrophilic gama-Fe2O3 Nanoparticles for Biomedical Applications
Authors: Malaeru Teodora , Enescu Elena , Georgescu Gabriela , Patroi Delia , Manta Eugen , Patroi Eros Alexandru , Morari Cristian , Marinescu Virgil
Published: January 2020

The hydrophilic g-Fe2O3 nanoparticles coated with polyvinylpyrrolidone (PVP) were prepared in one step of the modified polyol method combined with an additional heat treating. The presence of maghemite (g-Fe2O3) phase was confirmed by using X-ray diffraction (XRD) and Raman Spectrometry on powder. FT-IR spectroscopy confirmed the presence of PVP on the nanoparticles surface and the Zeta potential also supported the coating of nanoparticles with a layer of PVP and a good stability in aqueous medium. SEM analysis showed that the prepared g-Fe2O3 nanoparticles have a spherical structural morphology with the tendency of agglomeration. Hysteresis loop shows a ferromagnetic behaviour at room temperature with a saturation magnetization up to 57 emu/g.