bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolation, Purification, and Characterization of Pecan Nut Lipase and Studying its Affinity towards Pomegranate Extracts and 1, 4-Diacetoxybenzene
Authors: Alabbas K. S. , SALIH O. A. , Al-ABBASY O. Y.
Published: March 2022

This study included partial purification of the lipase enzyme from the karnel of the pecan nut. After applying ion exchange chromatography technique using CM-Cellulose, two lipase isoenzymes were observed with specific activity values of 2.66 and 1.7 units/mg protein. The highest activity of both isoenzymes appeared at the optimum pH values of 8 and 6 and at temperatures of 40 and 50 °C, respectively. A pure single band was obtained by using electrophoresis technique and it was found that the approximate molecular weight was 42 kDa for the two isoenzymes. The study dealt with the preparation of the diester compound 1,4-diacetoxybenzene, which was diagnosed by GC-MS and 1H NMR spectrometry. When studying the inhibition mode, the above compound showed a competitive inhibition of the lipase, as the value of Km increased from 0.013 to 2.857 mM, and Vmax was 0.25 enzymatic units / ml / min. Inhibition constant Ki was calculated and its value was 0.0319 mM.  Pomegranate peel extracts with chloroform and ethyl acetate revealed an activating effect on lipase. This research aims to detect the presence of lipase in the pecan nut karnel and purify it by biochemical methods to know its properties and molecular weight. Then we attempted to inhibit it with a laboratory-prepared compound that has a structure similar to the basic substance on which the enzyme works.
The development of the unified version mixing maps between arbitrary sets
Authors: Al-Bayati Salam Adel , Al-Sabbagh Akram , Al-Tameemi Omar , Saleh Manaf Adnan
Published: March 2022

The concepts of nonlinear mixed summable families and maps for the spaces that only non-void sets are developed. Several characterizations of the corresponding concepts are achieved and the proof for a general Pietsch Domination-type theorem is established. Furthermore, this work has presented plenty of composition and inclusion results between different classes of mappings in the abstract settings. Finally, a generalized notation of mixing maps and their characteristics are extended to a more general setting.
Photodynamic inactivation (effect of laser with and without photosensitizer) on viability of streptococcus pyogenes
Authors: Al-saidy Mawadamousa mousa
Published: March 2022

Abstract:

      Burns wounds infection is the high most frequent complications of burns as a result of penetration of bacteria from neighboring tissue.   Because of expanded utilization of antibiotics, the spread of multi-drug resistance bacteria emerge as one of alarming hazard to public health.

Photodynamic inactivation is the technique that can be used to prohibit these organisms. This study focused on bactericidal potency of toluidine blue (TBO) photosensitizer and red laser radiation of 635nm with different doses against multi-drug resistant streptococcus pyogenes (S. pyogenes) isolated from infected burns wounds to see if it is susceptible to photodynamic inactivation .

A total of 45 isolates were collected from 38 patients with infected burns wounds samples were collected from September to December 2019.Burns wounds swabs were employed using standard procedure of swab collection. Among these, eleven isolates were multidrug resistant S.pyogenes. More resistant isolate that has been proved to all antibiotics used. This multidrug resistant isolate used in all experiments. Bacterial suspension was diluted by using serial dilution.  The suspension of S. pyogenes in normal saline was treated with red laser radiation at a wavelength 635nm with and without TBO, and investigated the effect of changing laser doses (3.6 ,7 and 10.8 J/cm2) corresponding to laser exposure time (5,10 and 15 minutes  and different photosensitizer concentrations on viability of S. pyogenes isolated from infected burns wounds. The results of this study suggest that multi- drug resistance S pyogenes isolated from infected burns wounds inhibited by using photodynamic inactivation mediated by TBO and red laser at a wavelength 635 nm.  The effective technique for killing or inhibiting S. pyogenes isolated from infected burns wounds is the combination of red laser at a wave length 635nm and TBO. Combination of TBO and red laser light prohibit S. pyogenes, the optimum results of bacterial inhibition obtained at 50µg/ml, and laser dose 7 J/cm2  corresponding to exposure time 10 minutes.
Brexit: The Covid Pandemic Masking the Effects of Leaving the EU
Authors: MACKUL’AKOVÁ Markéta , HYNEK Ondrej
Published: March 2022

On 31 January 2020, the United Kingdom’s membership of the European Union ended 47 years after its accession. The agreement provided for a transitional period until 31 December 2020 to renegotiate the long-term relationship between the United Kingdom and the European Union (EU). Almost eleven months after the UK’s actual departure from the EU, the extent of the economic consequences of Brexit is still difficult to measure. According to European forecasts, it should cost the United Kingdom 2.2 points of GDP by the end of 2022. Trade with the continent has already declined. Exports to the EU fell by 12% between July 2018 and July 2021. The trend is similar for imports, a decrease of 13%. In both cases, the all-time low was reached last January, during the first month of Brexit, when the disorganization of customs controls culminated. The impact of Brexit is expected to increase next year. The UK ‘s GDP decline in 2020 was 9.9%, the largest decline since 1920. The fact that UK trade with non-EU countries fell by only 0.8% over the same period suggests that most of the decline was due to the impact of Brexit and not to the COVID-19 pandemic.
THE ENGLISH ABSTRACT IN JOURNAL ARTICLES ON APPLIED LINGUISTICS: LEXICO-GRAMMATICAL FEATURES
Authors: Nu My Nhat Ton , Thi My Hao Phan
Published: March 2022

This study explores the lexico-grammatical features of the abstracts of research articles (RAAs) in the field of applied linguistics. The data for this study is 30 RAAs from the two journals - English for Specific Purposes Journal (ESPJ) and TESOL Quarterly Journal (TSQJ). The analysis was based on Systemic Functional Grammar (SFG) as an analytical tool and confined to three systems of transitivity, modality and thematisation. The results reveal that regarding transitivity, an overwhelming majority lies with material and relational processes although all types of processes are present. As for modality, most of the clauses are non-modalised. As far as thematic structure is concerned, this genre contains mainly single unmarked topical themes; the use of multiple, interpersonal and textual themes is infrequent. The results of this study hold practical implications for teaching English for Academic Purposes.
Hanley procedure and TROPIS method – modern therapeutic approaches in complicated anal fistulae
Authors: Kołodziejczak Małgorzata , Ciesielski Przemysław
Published: March 2022

High recurrence rates after surgical management of complicated anal fistulae and concerns over postoperative incontinence encourage surgeons to look for new surgical solutions. Fistulas with high purulent reservoirs in diagnostic imaging are particularly challenging. Surgical opening of high branches and purulent reservoirs is a key therapeutic element in the management of complex fistulas. Access to these reservoirs should be established via the simplest route, hence for example, the deep postanal space should be reached from the outside by separating the external sphincter fibers, while the shortest access to high intersphincteric reservoirs is through the anal canal. The paper discusses two surgical approaches: a historical method proposed many years ago by Hanley and involving a wide opening of the deep postanal space, and TROPIS, which is a new, recently published method for accessing high intersphincteric fistulas. We describe the techniques, indications and contraindications for these two approaches. We concluded that proper patient qualification for the above therapeutic approaches is crucial. Pre-operative MRI or transrectal ultrasound imaging of the fistulous tract and determining the shortest drainage route are important.
Zastosowanie materiału Cention Forte u pacjenta w wieku rozwojowym
Authors: Korporowicz Emil , Dudek Małgorzata
Published: March 2022

Modern composite materials have become the standard in restorative dentistry. However, they are not perfect, especially when working with a young patient, where ease and speed of procedure is important. Glass-ionomer materials, despite many desirable properties such as remineralization potential and ease of use, have limited evidence of long-term clinical efficacy. New materials are being developed that combine some of the features of composite and glass ionomer materials. One of them is Cention Forte (Ivoclar Vivadent), which belongs to the alkasite group. A 16-year-old patient, generally healthy, was admitted to the Department of Pediatric Dentistry, UCS WUM. It was decided to start conservative treatment with a cavity in tooth 47 – I class according to Black, code 4 according to ICDAS II. The cavity was completely prepared and filled with Cention Forte. The “occlusal stamp” technique was used to restore the occlusal surface properly. The use of a new generation alkaside material in this clinical case was associated with a simple procedure. Material properties described in laboratory studies may be beneficial to the patient. However, adequate randomized clinical trials are needed to evaluate the clinical efficacy of the material.
PEMBERDAYAAN MASYARAKAT MELALUI PROGRAM KAMPUNG TANGGUH SEMERU WIROSECANG DALAM PENANGGULANGAN COVID-19 DI KELURAHAN WIROBORANG KOTA PROBOLINGGO
Authors: Mubaroq Husni , Ulfia Risza
Published: March 2022

Tulisan ini membahas tentang pemberdayaan pada masyarakat selama masa pandemi covid-19 di Kelurahan Wiroborang Kecamatan Mayangan Kota Probolinggo. Muncul banyak sekali permasalahan selama masa pandemi covid-19 hingga berdampak pada ekonomi dan sosial masyarakat. Tulisan ini bertujuan untuk mengetahui manfaat pemberdayaan masyarakat melalui program Kampung Tangguh Semeru Wiro Secang di Kelurahan Wiroborang Kecamatan Mayangan Kota Probolinggo. Pengumpulan data dilakukan dengan cara observasi, wawancara, dan dokumentasi. Narasumber dalam penelitian adalah Lurah Kelurahan Wiroborang dan Bhabinkamtibmas dari POLRES Kota Probolinggo. Hasil menunjukan bahwa pemberdayaan masyarakat melalui program Kampung Tangguh Semeru Wiro Secang di Kelurahan Wiroborang Kecamatan Mayangan Kota Probolinggo dapat dinyatakan telah berjalan dengan baik hingga sekarang. Dengan menggunakan konsep pemberdayan menurut teori ACTORS Sarah Cook dan Stevey Macaulay telah menghasilkan input yang telah direncanakan sebelumnya dan dapat diantisipasi sejak sekarang sementara output yang dihasilkan akan memiliki dayaguna yang maksimal kepada masyarakat sehingga mengarah pada perubahan yang positif dan bisa membantu ekonomi dan sosial pada masyarakat Kelurahan Wiroborang Kecamatan Mayangan Kota Probolinggo.
PENGOPTIMALAN PERAN MAHASISWA PADA MASA PANDEMI COVID-19 MELALUI KEGIATAN KKM FMIPA UNTAN
Authors: Muhardi Muhardi , Yudhi Yudhi , Risko Risko , Perdana Hendra , Alimuddin Andi Hairil , Hasanuddin Hasanuddin , Saputra Firman , Febriyanto Ferdy , Suhardi Suhardi
Published: March 2022

Kegiatan Kuliah Kerja Mahasiswa (KKM) Tahun 2020 dilaksanakan oleh Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) Universitas Tanjungpura (Untan) secara daring agar memperhatikan protokol kesehatan dalam pencegahan Corona Virus Disease 19 (COVID-19). Kegiatan ini dilakukan pada semester ganjil tahun 2020/2021, dari tanggal 6 Juli – 20 September 2020. Mahasiswa yang mengikuti kegiatan KKM sebanyak 242 orang, yang berasal dari 9 program studi di FMIPA Untan, dan tersebar di 5 propinsi yaitu Kalimantan Barat, Kepulauan Riau, DKI Jakarta, Jawa Timur, dan Sumatera Utara. Peserta yang melaksanakan program kelompok yaitu 95% digitalisasi pembelajaran untuk sekolah dasar dan menengah, 75% sosialisasi dan edukasi pencegaham covid-19, 71% penyaluran bantuan sosial bencana alam dan masyarakat tidak mampu, 37% penguatan usaha ekonomi masyarakat sebesar, dan 37% program perencanaan dan pengembangan desa. Sedangkan peserta yang melaksanakan program individu yaitu 75% pelayanan masyarakat, 67% layanan edukasi, dan 44 % membantu program pemerintah daerah.
UPAYA MENINGKATKAN KESEHATAN SANTRI MELALUI EDUKASI KESEHATAN DI PSAA BABUSSALAM
Authors: Rahayu Sri Mulyati , Pratidina Eki , Yuliani Meda , Helena Denni Fransiska , Andriansyah Ivan , Isronijaya M.
Published: March 2022

Yayasan Ramda Bhakti Pertiwi merupakan yayasan yang bergerak dalam bidang social dan pendidikan. Yayasan ini menyelenggarakan Pondok Pesantren Salafiyah (PPS), Ulya Babussalam (SMA), Wustho Babussalam (MTS) yang terletak di Jl. Cilengkrang II. Yayasan ini menyediakan asrama putra dan putri yang terdiri atas anak yatim, yatim piatu, dan kaum dhuafa. Panti Asuhan Babussalam terdiri atas 61 orang santri MTS dan 47 santri SMA. Kegiatan rutin yang dilakukan di Panti Asuhan Babussalam adalah sekolah dan mengaji. Hasil pengamatan pada tanggal 18 Oktober 2021, beberapa santri mulai tidak menggunakan kembali masker karena keterbatasan masker, dan masker kain yang dibuat oleh santri juga sudah habis terpakai. Hasil wawancara dengan pengelola sangat mengharapkan adanya pemaparan tentang vaksin covid-19 kepada para santri, sehingga para santri siap ketika akan divaksin dan tidak ada yang jatuh sakit setelah divaksin. Selain itu, pengelola juga mengharapkan adanya edukasi tentang kesehatan reproduksi pada remaja putri ketika sedang haid, dan kebersihan kulit agar tidak terus menerus timbul gatal-gatal. Hasil wawancara dengan 5 santri yang ditemui saat survey, kelima santri tersebut belum siap dilakukan vaksin covid-19, karena masih takut menjadi sakit. Untuk itu, kami perlu dilakukan pengabdian kepada masyarakat di Panti asuhan Babussalam ini untuk mengingatkan kembali pentingnya penerapan protokol kesehatan, mengedukasi tentang vaksin covid-19, kesehatan reproduksi saat haid, kesehatan kulit, dan dapat mempraktekkan cara membuat sabun cair untuk melengkapi saat cuci tangan.
Two-Dimensional Dam Break Modelling of Beris Dam using HEC-RAS
Authors: Mohamad Nur Azura , Che Ros Faizah
Published: March 2022

Dam is built for various functions such as water supply, flood and sediment control, electricity generation and irrigation. Floods due to dam breaches create higher peak flows than floods produced by heavy rainfall. When a dam collapses, the stored water may cause devastating catastrophe towards downstream areas by causing fatalities and property damages. The aim of this study is to perform a two-dimensional dam break modelling of Beris Dam due to probable maximum flood (PMF). The HEC-RAS software was used to predict the breach outflow’s hydrograph and produce the flood inundation and velocity map. Dam breach parameters were calculated using Froehlich and MacDonald and Langridge-Monopolis (MDLM) equations. A 4-day simulation conducted showed that a breach was initiated at almost 10.35 am, 34 hours and 35 minutes after the PMF scenario. Peak discharge during the PMF failure is 10,745.12 m3/s at 12.45 pm the next day which is after 2 hours and 10 minutes of dam breach initiation. Felda Lubuk Merbau, Kampung Betong, Jeniang, Padang Serai and Kota Kuala Muda are among the areas affected by the simulated Beris Dam break. Information obtained on flood velocity, depth and arrival time are useful to local authorities in order to respond effectively and immediately in the event of dam break.
Analysis of tropical cyclones 2000-2020 in Madagascar
Authors: Zy Misa Harivelo Rakotoarimanana , Zy Harifidy Rakotoarimanana , Moses Glorino Rumambo Pandin , Christrijogo Sumartono Waloejo
Published: March 2022

Madagascar is among the ten countries most exposed to cyclonic disasters in the world due to its geographical position. The country faces serious problems directly related to tropical cyclones every year. This research aims to analyze the cyclones in Madagascar from 2000 to 2020 focusing on the impact of the cyclone based on human losses and costs. The findings showed that during the past 20 years, 39 significant cyclones have affected Madagascar. On an average, 02 cyclones per year hit the country but its frequency has been decreasing since 2014. Cyclone Eline, Gafilo and Ivan were considered the most dangerous and have caused serious damages to the country. The number of victims caused by the cyclone, Eline, in 2000 were numerous while the cyclone Ivan in 2008 led many people to homelessness. In addition, the cyclone Gafilo in 2004 was recorded as the deadliest, costliest and has provoked many injuries including missing people. The number of victims, homeless, injured, missing and the cost of damage increase depending on the intensity of the cyclone. The East, North-East, West and Southwest coasts are most often hit by cyclones. Despite the frequency and damage of cyclones in the country, the actions carried out to reduce or mitigate the impacts of cyclones are still not sustainable, which makes the populations more vulnerable.
Assessment of drought, its causes and consequences in connection with local wisdom: a case study of Kohat basin drought-2017, Khyber Pakhtunkhwa, Pakistan
Authors: Khan Shah Nawaz , Khan Amir Nawaz , Khan Muhammad Amjad , Shah Syed Azmat Ali , Naqash Tayyab
Published: March 2022

Extreme weather events are significantly increasing around the globe. Among these, drought is a unique environmental hazard. Its uniqueness is the length of time between the first indications and impacts upon the community. Droughts may occur for months, years and in some cases decades, affecting large geographical areas. This study aims to assess the occurrence, causes and impacts of drought regimes technically by using the Standardized Precipitation Index (SPI) technique and culturally by assessing the local people's indigenous knowledge. For this purpose, both primary and secondary data were collected. Historically recorded rainfall data were used to calculate SPI values to identify rainfall deficits for 3, 6 and 12 months timescales. Data about the indigenous knowledge was collected through focus group discussions and interviews with the community. Secondary data were collected from Agriculture Department, Irrigation department, BARANI research station and Pakistan Meteorological Department (PMD). The study results revealed that mild and moderate droughts are decreasing as the timescale increases. Contrary, severe and extreme droughts increase with the increase in timescales from 3 months to a year. Results also highlighted three extreme drought events recorded in the study area based on SPI-3 and SPI-6 timescales from 1954 to 2017. The number of extreme droughts based on SPI-12 is five in the selected timeframe. Furthermore, there was a significant reduction in agriculture production particularly in crops and vegetables during drought-2017. The findings of the study recommend that there is a need to improve the irrigation system. Wastage of floodwater should be controlled and conserved in small dams. Coordination amongst the stakeholders, advanced early warning system, awareness and planning at the local are significant measures to be taken in the study area to combat the problem.
Valeurs nutritives, propriétés antioxydantes et cytotoxicité des cossettes de Dioscorea dumetorum pour la valorisation en alimentation animale et humaine au Bénin
Authors: Jospin Akadiri Faride , Boya Aboh André , Abiodoun Olounlade Pascal , Fidèle Assogba , Frédéric Houndonougbo
Published: March 2022

Le présent travail vise à évaluer la valeur nutritive et les propriétés antioxydantes de D. dumetorum pour une meilleure valorisation en alimentation humaine et animale. Les tubercules frais ont été découpés en morceaux, cuits dans l’eau pendant 30, 60 et 90 minutes puis séchés au soleil pour obtenir respectivement des cossettes CD30, CD60 et CD90. Les dosages chimiques et phytochimiques ont été réalisés sur les différents types de cossettes. La teneur en cendres totales a varié de 3,36 à 3,55 %. La teneur en protéines brutes a varié de 7,86 à 9,8 %. Quant à la teneur en cellulose brute, elle a varié de 0,69 à 1,71 %. Au total, 10 classes de métabolites secondaires sont présentes dans les cossettes. Les teneurs en polyphénols totaux, en flavonoïdes et en tanins sont plus élevées dans les cossettes CD30. Le taux d’inhibition des radicaux libres a varié de 51,97 à 54,08 %. La valeur de concentration inhibitrice 50 % a varié de 2,62 à 12,10 µg/mL dans les cossettes. D. dumetorum est une ressource alimentaire dont la capacité antioxydant pourrait contribuer à la prévention des dommages causés par le stress oxydatif et par conséquent à l’amélioration de la productivité chez les animaux.
Modern information technologies as a tool for reducing working population poverty
Authors: Karimov A. G. , Fatkullina G. R.
Published: March 2022

Rapid development and implementation of modern information and communication technologies has led to a new phase of economic, scientiﬁc and technological progress. However, there is no mechanism to ensure social systems effective management based on the information technologies use due to socio-economic inequality among the population of the Russian Federation, preventing all segments of the population from beneﬁting scientiﬁc and technological progress results, which has been exacerbated by the COVID-19 pandemic. The aim of the study is to identify the modern information technologies role in improving the living standard and the population life quality, in particular, in overcoming the working population poverty. The article analyses foreign and domestic research on this issue over the past ﬁve years. The pandemic impact on social structures, in particular the labour market and employment, has been considered. The growing importance and social networks role in public life and their use serious potential to solve the problems under study have been noted. The authors carried out a sociological survey in the Republic of Bashkortostan, on the basis of which made conclusions: modern society is characterised by the information inequality problem, which is closely linked to the economic inequality problem, which will be exacerbated by the modern information and communication technologies development; the computer illiteracy problem and the close relationship between income level and knowledge, skills in information and communication technologies, English language skills were identiﬁed among residents. The research results highlight the need to implement modern information technologies skills into poverty alleviation programmes.
Design and Application of an Immobilized Protein Kinase
Authors: Deane Dalton , Cope Thomas , Schulz Anna , Bennett Edward , Hughes Robert
Published: March 2022

Protein Kinase A (PKA) is a biologically important enzyme for cell regulation, often referred to as the “central kinase”. An immobilized PKA that retains substrate specificity and activity would be a useful tool for laboratory scientists, enabling targeted phosphorylation without interference from downstream kinase contamination or kinase autophosphorylation in sensitive assays. Moreover, it might also offer the benefits of robustness and reusability that are often associated with immobilized enzyme preparations. In this work, we describe the creation of a recombinant PKA fusion protein that incorporates the HaloTag covalent immobilization system. We demonstrate that protein fusion design, including affinity tag placement, is critical for optimal heterologous expression in E. coli. Furthermore, we demonstrate various applications of our immobilized PKA, including the phosphorylation of recombinant PKA substrates such as VASP and endogenous PKA substrates in a cell lysate. These results hold promise as a generalizable strategy for the production and application of immobilized protein kinases involving specific sequestration of a fusion protein by a solid support material.
Assessment of ten-year dynamics of cases of hospitalizations of patients with peptic ulcer disease, chronic gastritis and chronic duodenitis
Authors: Butov Mikhail A. , Zhestkova Tatyana V. , Esakova Evgeniia M. , Efanova Larisa V.
Published: March 2022

Aim. To assess of the ten-year dynamics of cases of hospitalizations of patients with peptic ulcer disease (PUD), chronic gastritis and chronic duodenitis relative to the total number of people treated in the gastroenterological departments of the hospital in 20102019.
Materials and methods. Data of the annual reports of the work of the hospital departments were studied retrospectively.
Results. The relative number of persons hospitalized for chronic duodenitis decreased 2.8 times (p0.001), but the proportion of patients with chronic gastritis did not tend to decrease. This is most likely due to diagnostic errors. The cases of hospitalization of persons with uncomplicated PUD decreased by 3.1 times (p0.001), the proportion of men with duodenal ulcer decreased by 6.3 times (p0.001), with gastric ulcer decreased 1.9 times (p0.01). The proportion of women hospitalized with duodenal ulcer decreased 2.3 times (p0.01). The number of hospitalized men with duodenal ulcer is 3.8 times more than females (p0.001). It can be explained by a decrease in social stressful influences and active anti-Helicobacter pylori therapy.
Conclusion. Over the period of follow-up, the cases of hospitalization of patients with uncomplicated PUD decreased, primarily due to a decrease in the proportion of persons with ulcer of the duodenum and duodenitis, while the number of patients with chronic gastritis not undergoing modern examination did not have significant dynamics.
Characteristic of disorders of motor-evacuator activities of the stomach and intestinal in chronic duodenal insufficiency
Authors: Vakhrushev Yakov M. , Busygina Marina S. , Vatulin Valerii V.
Published: March 2022

Aim. To assess the psychoemotional status and the state of the autonomic nervous system and their importance in the violation of the motor-evacuation function of the gastrointestinal tract in chronic duodenal insufficiency (CDI).
Materials and methods. A prospective study of 40 patients with CDI was carried out. The control group consisted of 30 healthy individuals. Anamnestic and physical data, results of X-ray and endoscopic studies, and intracavitary manometry were used to verify CDI. The study of the gastrointestinal tract was carried out using the "Gastroscan-GEM". Assessment of autonomic homeostasis was carried out using cardiac rhythmographic research and analysis of heart rate variability using the "Varicard 2.51" complex. To assess personal and situational anxiety test questionnaire SpielbergerKhanin. Eysenck's test questionnaire was used to determine the type of temperament.
Results and discussion. We revealed a postprandial decrease in the contribution of the frequency spectrum of the duodenum (Pi/Ps 1.70.07; p=0.000) and the colon (Pi/Ps 39.622.45; p=0.000) in the total spectrum in comparison with the starving study, at the same time there is an aberrant significant increase in the contribution of the stomach to the total spectrum (46.55.8%; p=0.00). In patients with CDI, the prevalence of the sympathetic division of the autonomic nervous system AMo was noted 94.0 [92.5; 97.5]% with an asymptotic type of autonomic reactivity (IN2/IN1=1.1 [1.05; 1.17]) and insufficient adaptation reserve coefficients (0.32 [0.2; 0.4]) in relation to the control group. The psychoemotional state in patients with chronic duodenal stasis is in direct correlation with changes in the postprandial ratio of the electrical activity of the stomach and duodenum (r=0.7, p=0.021), and in reverse with the coefficient of the ratio of intraduodenal pressure to intragastric pressure (r=-0,8, p=0.000).
Conclusion. In patients with CDI, changes in the functional state of the stomach and duodenum are of a systemic nature, which is due to stimulating (parasympathetic) and inhibitory (sympathetic) effects. The relationship between the motor-evacuation activity of the stomach and duodenum and the psychoemotional state in patients with CDI was revealed.
The role of the main risk factors and endocrine cells of the antrum of the stomach producing motilin in the occurrence of cholelithiasis
Authors: Svistunov Andrey A. , Osadchuk Mikhail A. , Mironova Ekaterina D. , Guliaev Pavel V. , Vasileva Inna N.
Published: March 2022

Aim. To establish the role of the main risk factors and endocrine cells of the antrum of the stomach producing motilin (M-cells) in the occurrence of cholelithiasis.
Materials and methods. The first group included 122 patients with cholelithiasis. The second group consisted of 30 healthy individuals who underwent medical examination. The groups were matched for gender and age. The work analyzed anamnestic, biochemical and anthropometric data. All patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucous membrane from the antrum. Biopsies were subjected to cytological and immunohistochemical studies in order to verify Helicobacter pylori and estimate the number of M-cells.
Results. Patients with cholelithiasis more often belonged to the group of people of mental labor, had low physical activity, were committed to inappropriate nutrition and more often indicated the presence of aggravated heredity for cholelithiasis. Patients with gallstone disease had higher body mass index, waist volume, total cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, lower high-density lipoprotein cholesterol, H. pylori infection was more often verified and M-cell hypoplasia in the mucous membrane was established. stomach in comparison with the representatives of the second group.
Conclusion. Our results suggest that certain external factors, nutritional characteristics of the metabolic syndrome components, hypoplasia of M-cells in the gastric mucosa are important factors in the formation of calculi in the gallbladder.
The effectiveness of eradication therapy of the 1st line of Helicobacter pylori infection in patients with type 2 diabetes mellitus
Authors: Maev Igor V. , Mkrtumyan Ashot M. , Bektemirova Luiza G. , Andreev Dmitry N. , Dicheva Diana T.
Published: March 2022

Aim. Evaluation of the efficacy and safety of eradication therapy of infection Helicobacter pylori in patients with H. pylori- associated pathology of the upper gastrointestinal tract and concomitant type 2 diabetes mellitus (DM).
Materials and methods. The prospective randomized study involving 180 patients (87 men and 93 women) with H. pylori- associated pathology of the upper gastrointestinal tract was carried out. The patients were divided into four groups of 45 people: 1 patients without diabetes who received the classic triple eradication therapy; 2 patients with type 2 DM who received the classic triple eradication therapy; 3 patients without DM who underwent quadrotherapy with bismuth preparations; 4 patients with type 2 DM who underwent quadrotherapy with bismuth preparations. Eradication therapy was carried out for 14 days. Evaluation of the effectiveness of eradication using a breath test was carried out 4 weeks after completion of the course of treatment. Eradication success was assessed separately for ITT and PP analyzes.
Results. The effectiveness of classical triple eradication therapy in patients with concomitant type 2 DM is 64.4% in the ITT group and 69.05% in the PP: quadrotherapy 73.34 and 80.49%, respectively. The effectiveness of first line eradication therapy is higher in patients without DM compared with groups of patients with concomitant type 2 DM: ITT 83.33%, PP 88.23% and ITT 68.89%, PP 74.70%, respectively. The incidence of side effects in patients with type 2 DM: with the use of classical triple therapy 22.23%, quadrotherapy 31.12%.
Conclusion. The data of the study of the efficacy and safety of line I eradication therapy make it possible to recommend the four-component therapy based on bismuth for use in clinical practice, especially in patients with DM.
COVID-19 as a trigger of autoimmune hepatitis. Case report
Authors: Volchkova Ekaterina A. , Legkova Kristina S. , Topchy Tatiana B.
Published: March 2022

Over the past two years, the entire medical community has taken up the fight against the new coronavirus infection. At the initial encounter with COVID-19, it seemed that this virus mainly affects the respiratory system. Still, with long-term observation, it turned out that the consequences of this disease can be much more severe and associated with lung damage and thromboembolic complications, and be a trigger for autoimmune diseases. According to the literature, after suffering COVID-19, some patients debuted systemic lupus erythematosus, hemolytic anemia, thrombocytopenia, developed GuillainBarr syndrome, vasculitis, and multiple sclerosis, and a case of autoimmune hepatitis (AIH) was described in foreign literature. AIH is a fairly rare disease, the prevalence of which in Europe is 1618 cases per 100 thousand inhabitants, affecting mainly women. It is known that chemicals and drugs (minocycline, diclofenac, methyldopa, infliximab, etanercept), viruses (HAV, HEV, EBV, HCV, CMV), environmental factors can serve as triggers of the autoimmune process in the liver. This article presents two clinical cases of AIH that developed after suffering a new coronavirus infection, which we consider as the initial provoking factor of autoimmune inflammation. Given the rarity of AIH, the description of new triggers is of clinical interest. It may be useful for doctors of different specialties since they faced drug-induced liver damage against the background of antiviral and immunobiological therapy. In the domestic literature, there have not yet been any publications devoted to the debut of AIH in adults after coronavirus infection.
The history of the discovery of the Helicobacter pylori
Authors: Bordin Dmitry S. , Shengelia Mariam I. , Ivanova Valeriya A. , Voynovan Irina N.
Published: March 2022

Helicobacter pylori is a spiral-shaped gram-negative bacterium that colonizes the stomach lining. The presence of a microorganism in humans was described more than a century ago, but from detection to recognition of its role in the etiology and pathogenesis of diseases of the stomach, researchers had to overcome a long path of criticism and mistrust. Coiled bacteria have been mentioned several times in the medical literature, but these bacteria were thought to be contaminants, and any evidence of the bacteria in the stomach was ignored by the medical community. The discovery of H. pylori led to a revolutionary rethinking of the mechanisms of development of a number of diseases: the role of bacteria in the development of chronic gastritis, peptic ulcer disease, stomach cancer and MALT lymphoma was proved. The principles of their prevention and treatment have changed. For this discovery in 2005, Barry Marshall and Robin Warren were awarded the Nobel Prize in Medicine and Physiology.
Factors Affecting the Online Hotel Reservation – A Multiple Regression Analysis
Authors: Zia Sayma , Khan Ayesha , Abbas Insiya , Idrees Muhammad Abdullah
Published: March 2022

Purpose: Now-a-days online hotel reservations find very sensitive part among any activity performed by individuals where we can see that consumers are facing a lot of difficulties and risks in order to confirm their bookings, because with the passage of time it’s been found that the internet usage is increased likewise risk factors and fraudulent activities have also been taking place more frequently so that’s why people feel hesitations and confusions in order to confirm their bookings because now-a-days as much internet usage have been increased likewise risk factors and fraudulent activities have also been taking place more frequently so that’s why people feel hesitations and confusions in order to find their hotel reservations done.

Design/Methodology/Approach: The purpose of this research study will be a detailed nature creating use of data and information asked from the research instruments. The study adopted two major research approaches, namely qualitative approach and quantitative approach during data collection and presentation. Random sampling is used as a sampling technique.

Findings: Overall results indicate that Security Risk, Financial Risk, Trust, and Consumer psychology all are important dimensions of online reservations. All these variables are important for an organization’s functions and increasing efficiency and effectiveness.

Implications/Originality/Value: This study can be helpful for all the hospitality industry related organizations who want to measure risk factors for online reservations. Organizations in private sectors and other industries can also be included in further research work. Managers should make sure that they and their subordinates follow the process flows on online sales of their brand, and do not make any exceptions.
REPRESENTASI MADURA DALAM PERTUNJUKAN SENI TARI SILA KARYA HARI GHULUR
Authors: Tjahyadi Indra , Faishal Ahmad
Published: March 2022

Artikel ini memfokuskan kajiannya pada indentitas masyarakat Madura yang direpresentasikan dalam pertunjukan tari Sila karya Hari Ghulur. Sila merupakan pertunjukan seni tari yang diciptakan dan dimainkan oleh Hari Ghulur. Tujuan dilakukannya kajian ini adalah mendeskripsikan identitas masyarakat Madura yang direpresentasikan dalam seni pertunjukan, khususnya pertunjukan seni tari Sila karya Hari Ghulur. Teori yang digunakan sebagai landasan analisis adalah teori semiotika Roland Barthes. Adapun metode yang digunakan sebagai landasan tahapan analisis adalah metode kualitatif interpretif. Adapun penggunaan metode tersebut karena adanya relevansi antara topik kajian dan teori yang digunakan. Berdasarkan analisis yang dilakukan ditemukan bahwa pertunjukan tari Sila karya Hari Ghulur masyarakat Madura merepresentasikan masyarakat sebagai masyarakat (1) egaliter, (2) santri, dan (3) tangguh.
Efek Manipulasi pH pada Aktivitas Enzim Selulase Bakteri Bacillus subtillis Strain FNCC 0059 dalam Mendegradasi Selulosa
Authors: Kartika Ismi Nurul , Ibrahim Muslimin
Published: March 2022

Selulase merupakan enzim yang mempunyai fungsi penting dalam mengubah bahan limbah organik selulosa. Selulase merupakan kelompok enzim yang minimal terdiri dari tiga enzim yaitu endoglukonase, eksoglukonase dan Î²-glukonase yang bekerja sinergis supaya dapat mendegradasi selulosa menjadi  glukosa. Glukosa tersebut digunakan sebagai sumber karbon dan nutrisi pertumbuhan bakteri. Enzim selulase kasar termasuk enzim ekstraseluler yang didapatkan pada isolat bakteri selulolitik. Bakteri yang berpotensi memproduksi enzim selulase ialah salah satunya Bacillus subtilis. Bakteri ini dapat diisolasi dari air dan tanah. Penelitian ini bertujuan untuk menemukan pH optimal aktivitas enzim selulase B. subtilis. Penelitian menggunakan lima perlakuan pH (5, 6, 7, 8, dan 9) pada suhu 37o C dengan lima ulangan dan 25 sampel perlakuan menggunakan rancangan acak lengkap (RAL). Aktivitas enzim selulase diukur bersumber pada kandungan gula reduksi dengan metode asam 3,5 dinitrosalisilat (DNS). Data yang diperoleh dianalisis menggunakan Anova satu arah. Apabila berbeda nyata maka dilanjutkan dengan uji duncan. Hasil penelitian menunjukkan bahwa B. subtillis secara kualitatif menghasilkan zona bening yaitu sebesar 0,35 mm. Hasil Anova satu arah menunjukkan nilai signifikan terhadap perlakuan variasi pH namun setelah diuji Duncan taraf 5% perlakuan variasi pH tidak berpengaruh secara nyata. Kesimpulan dari penelitian ini yaitu manipulasi pH tidak berpengaruh terhadap aktivitas selulase. Implikasi dari penelitian ini adalah B. subtillis strain FNCC 0059 dapat dimanfaatkan untuk membantu memecah sumber karbon selulosa menjadi glukosa.
Upaya Penurunan Logam Berat Timbal (Pb) pada Ikan Mujair (Oreochromis mossambicus) dengan Menggunakan Filtrat Tomat (Solanum lycopersicum)
Authors: Azmi Auliya , Winarsih Winarsih
Published: March 2022

Oreochromis mossambicus atau Ikan Mujair merupakan ikan favorit dan sering dikonsumsi oleh masyarakat Indonesia, namun masih sering tercemar oleh logam berat timbal. Jika logam berat timbal tertelan oleh manusia, maka sangat berbahaya apabila melebihi ambang batas maksimum. Sesuai dengan penetapan SNI No. 7387:2009, nilai ambang batas maksimum pencemaran logam berat timbal pada ikan ialah, sebesar 0,3 mg/kg. Oleh sebab itu, agar ikan mujair aman untuk dikonsumsi dibutuhkan cara untuk menurunkan nilai kadar logam berat timbal (Pb) pada ikan tersebut. Upaya untuk menurunkan kadar logam berat timbal dapat menggunakan buah tomat, dikarenakan buah tomat mengandung asam sitrat. Kandungan asam sitrat pada buah tomat berguna sebagai penghelat logam. Penelitian ini bertujuan untuk mengetahui penurunan kadar logam berat timbal (Pb) pada ikan mujair setelah dilakukan perendaman dengan berbagai konsentrasi filtrat tomat. Penelitian ini menggunakan jenis penelitian eksperimental. Sementara rancangan penelitian yang digunakan ialah Rancangan Acak Lengkap dengan satu faktor, yakni perbedaan pada konsentrasi filtrat tomat (0%, 50%, 75%, dan 100%) dengan waktu rendam selama 60 menit. Analisis kadar logam berat timbal (Pb) menggunakan metode Atomic Absorption Spectrophotometry (AAS). Penurunan nilai kadar logam berat timbal (Pb) dianalisis dengan ANAVA Satu Arah dan dilanjut dengan Uji Duncan. Kesimpulan dari penelitian ini yaitu terdapat pengaruh dari perbedaan konsentrasi filtrat pada penurunan kadar logam berat timbal. Konsentrasi paling optimum yaitu pada konsentrasi 75% yang dapat menurunkan logam berat timbal sebanyak 73,34%.
Optimasi Aktivitas Selulase Ekstraseluler Islolat Bakter EG 2 Isolasi dari Bungkil Kelapa Sawit (Elaesis guineensis jacq.)
Authors: Puspitasari Dian , Ibrahim Muslimin
Published: March 2022

Selulase merupakan salah satu enzim yang banyak digunakan dalam aplikasi industri. Faktor harga enzim merupakan kendala utama yang dihadapi industri berbasis enzim. Salah satu solusi yang dilakukan untuk menurunkan harga enzim adalah mengeksplorasi mikroba yang potensial sebagai penghasil selulase salah satunya isolat bakteri selulolitik EG 2 yang diisolasi dari bungkil kelapa sawit. Penelitian ini bertujuan menentukan suhu inkubasi optimum untuk aktivitas enzim selulase pada isolat bakteri selulolitik EG 2 dan menentukan pH optimum untuk aktivitas enzim selulase pada isolat bakteri selulolitik EG 2. Karakterisasi enzim ditentukan dengan menguji aktivitas enzim pada variasi suhu (35; 45; 55; 65; 75) °C ; variasi pH (5,0; 6,0; 7,0; 8,0; 9,0) kemudian diukur dengan metode asam 3,5 - dinitrosalisilat (DNS). Hasil penelitian menunjukkan bahwa isolat bakteri selulolitik EG 2 optimum pada suhu 65 °C dan pH 7,0 dengan aktivitas enzim sebesar 0,011 U/mL.
Preliminary Study on Deformation During Hydrostatic Testing in a Deep Tank
Authors: Kim Geun-Gon , An Tae-Hyun , Lee Tak-Kee
Published: March 2022

There are many different types of tanks on ships that meet various requirements. Each tank is required to undergo hydrostatic testing according to the Ship Safety Act after being installed onboard. In some hydrostatic tests, excessive deformation may occur. The overpressure of the air in the tank generated during testing is one of the possible causes of deformation. Based on the dimensions of the tank, nozzle, and pipes installed, it was confirmed that the overpressure of the air can cause problems with the structure, according to the Bernoulli equation. Additionally, finite element analysis (FEA) was performed on the tank structure to confirm the deformation and the stress occurring in the structure. From the perspective of deformation, the maximum deflection limit was set based on the criteria provided by the Eurocode and DNV. From the perspective of stress, the structural safety assessment was performed by comparing the allowable stress and equivalent stress generated in the structure. To determine whether the behavior of the actual structure was well implemented via FEA, beam theory was applied to the tank structure and compared with the FEA results. As a result of the analysis, severe deformation was found in some cases. This means that the overpressure of the air may be the cause of actual deformation. It was also confirmed that permanent deformation may occur.
Assessment for Learning Berorientasi Higher Order Thinking Skills untuk Menstimulus Kecakapan Literasi Numerasi
Authors: Khoiriah Khoiriah
Published: March 2022

Penelitian ini bertujuan menerapkan assessment for learning berorientasi higher order thinking skill untuk menstimulus kecakapan literasi numerasi siswa. Desain penelitian menggunakan pretest-posttest control group. Sampel penelitian melibatkan dua kelompok siswa dari dua belas kelompok siswa kelas VIII SMP Negeri 16 Bandar Lampung yang ditentukan secara random sampling. Instrumen pengumpul data berupa instrumen tes kecakapan literasi numerasi dan instrumen observasi kecakapan literasi numerasi. Data dianalisis secara deskriptif kualitatif dan kuantitatif dengan independent sample t test. Hasil analisis data menunjukkan kecakapan literasi numerasi siswa pada kedua kelas eksperimen terkategori “sangat tinggi” dengan rincian rerata 81,44% untuk kelas eksperimen 1 dan 81,93% kelas eksperimen 2, sedangkan tes kecakapan literasi numerasi siswa diperoleh nilai Sig (2-tailed) < 0,05 yaitu Sig (2-tailed) = 0,000 yang berarti pengujian hipotesis dinyatakan tolak H0 dan terima H1. Dapat disimpulkan bahwa assessment for learning berorientasi higher order thinking skill efektif untuk menstimulus kecakapan literasi numerasi siswa.
Estimation Of Water Saturation In Carbonate Reservoirs Without Resistivity Log Data. Part I: Theory And Existing Model
Authors: Widarsono Bambang , Atmoko Heru , Ridwan Ridwan , Kosasih Kosasih
Published: March 2022

This paper presents an observation over a suggested approach for establishing water saturation model that is specifically designed without the need of resistivity log data. One of the main strength of the approach is that the resulting water saturation model can be specifically established for local or specific use only. This is true since the approach can be applied using carbonate rocks that are obtained locally or from specific areas. Another important conclusion is that this approach can also be applied for any carbonate rock classification as long as the classification can clearly group carbonate rocks into groups with distinctive petrophysical properties. This paper – first part of two – presents theory and rock classification that underlines the approach, as well as procedure and the existing models available.