bluuebunny/crossref_metadata_2025 huggingface dataset:
Wpływ wybranych dodatków lekkich na zmianę parametrów technologicznych zaczynu
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Kremieniewski Marcin
Published: June 2022

W celu obniżenia gęstości zaczynów przeznaczonych do uszczelniania kolumn rur okładzinowych w warunkach obniżonego ciśnienia złożowego czy w strefach skał słabo zwięzłych stosuje się lekkie dodatki, takie jak mikrosfera bądź perlit. Użycie tego rodzaju materiałów pozwala na zredukowanie wartości ciśnienia hydrostatycznego i tym samym zapobiega ucieczce cementu w strefy słabo zwięzłe. Dodatkowo zaczyny o obniżonej gęstości mogą być stosowane w przypadku konieczności tłoczenia cementu w przestrzeni pozarurowej na dużą wysokość. Jednak wykorzystanie dodatków redukujących gęstość zaczynu nie pozostaje bez znaczenia dla parametrów technologicznych zarówno świeżego, jak i stwardniałego zaczynu. W przypadku płynnego zaczynu obecność lekkich frakcji powoduje zmianę parametrów reologicznych zaczynu, wzrost wartości filtracji bądź też odstoju wody. Natomiast analizując parametry stwardniałego zaczynu cementowego, należy się spodziewać obniżenia wartości wytrzymałości na ściskanie, wytrzymałości na zginanie, przyczepności do rur stalowych itp. Z uwagi na konieczność stosowania w recepturach zaczynów lekkich dodatków redukujących gęstość w niniejszej publikacji omówiono to zagadnienie na podstawie przeprowadzonych prac badawczych. W artykule przedstawiono wyniki badań zaczynów zawierających 4 różne dodatki (mikrosferę glinokrzemianową dotychczas stosowaną, mikrosferę glinokrzemianową nowej generacji CSF K, mikrosferę szklaną oraz perlit filtracyjny E100F). Dodatki lekkie stosowano w ilości 15% w stosunku do masy cementu. Przeprowadzono badania dla zaczynu kontrolnego (bez dodatków lekkich). Zaczyn ten zawierał w swoim składzie środki niezbędne do kontrolowania parametrów decydujących o efektywności uszczelniania otworu wiertniczego. Następnie receptura kontrolna była modyfikowana dodatkiem lekkich frakcji. Przeprowadzono badania laboratoryjne parametrów technologicznych zarówno świeżych, jak i stwardniałych zaczynów cementowych. Na podstawie uzyskanych wyników określono wpływ badanych lekkich dodatków na parametry świeżych i stwardniałych zaczynów cementowych.
Ocena kosztów produkcji wodoru z wykorzystaniem energii pochodzącej z instalacji fotowoltaicznej wybudowanej w Polsce
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Filar Bogdan , Miziołek Mariusz ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Kwilosz Tadeusz ,   Instytut Nafty i Gazu - Państwowy Instytut Badawczy
Published: June 2022

W 2020 r. Komisja Europejska (KE) ogłosiła strategię wodorową spójną z założeniami Europejskiego Zielonego Ładu. Strategia zakłada ograniczenie wykorzystania paliw kopalnych do produkcji energii i zastępowanie ich energią odnawialną (OZE), produkowaną głównie przez farmy wiatrowe oraz solarne. Sumaryczna moc uruchomionych instalacji fotowoltaicznych (PV) w Polsce w listopadzie 2021 r. osiągnęła wartość 7,1 GW. Obecnie największą elektrownią fotowoltaiczną w Polsce jest elektrownia o mocy 70 MW wybudowana przez ZE PAK w Brudzewie. Nadwyżki energii pochodzącej z OZE mogłyby zostać wykorzystane do produkcji tzw. zielonego wodoru. W publikacji przedstawiono wyniki analizy, której celem było określenie szacunkowych kosztów produkcji wodoru przez elektrolizer zasilany energią pochodzącą z farmy fotowoltaicznej (PV). W przeprowadzonej analizie założono, że wodór będzie produkowany przez elektrolizer PEM o mocy 2,5 MW. W związku z tym, że ilość produkowanej energii jest zmienna w czasie, to ilość produkowanego wodoru obliczono dla instalacji o mocy zmieniającej się w zakresie 7–11 MW. Zakres minimalny wielkości instalacji był tak dobrany, aby w czerwcu (najlepszym miesiącu dla fotowoltaiki w Polsce) elektrolizer mógł pracować z całą mocą. Natomiast górny zakres mocy instalacji, wynoszący 11 MW, został określony w taki sposób, aby elektrolizer pracował z maksymalną mocą od marca do października. Obliczenia wykazały, że instalacja o mocy 7 MW pozwoli wyprodukować około 1,34 mln mn3 wodoru, podczas gdy instalacja o mocy 11 MW może wyprodukować około 1,7 mln mn3 wodoru. W dalszej kolejności obliczono nakłady inwestycyjne dla wszystkich wariantów budowy instalacji fotowoltaicznej. Koszt budowy instalacji o mocy 7–11 MW zmieniał się w przedziale 34,4–44,7 mln zł. Natomiast roczne koszty operacyjne eksploatacji instalacji o mocy 7–11 MW zmieniały się w przedziale 1,19–1,4 mln zł. W dalszej kolejności obliczono koszt wyprodukowania 1 mn3 wodoru, zakładając eksploatację całej instalacji przez 20 lat. Koszt produkcji 1 mn3 wodoru uzyskano dzieląc sumę zdyskontowanych kosztów inwestycyjnych i operacyjnych, uzyskaną w okresie 20 lat, przez sumę zdyskontowanej ilości wyprodukowanego wodoru. Obliczenia wykazały, że optymalna instalacja PV dla elektrolizera o mocy 2,5 MW posiada moc 9 MW. Koszt produkcji wodoru obliczony dla instalacji PV o mocy 9 MW wyniósł 3,17 zł/n3
Wykorzystanie wodoru w gospodarstwie domowym na przykładzie urządzeń, w których zastosowano technologię ogniw paliwowych
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Basiura Maciej , Żyjewska Urszula ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy
Published: June 2022

W artykule przedstawiono tematykę zagospodarowania wodoru w kontekście polityk krajowych (np. Porozumienie sektorowe na rzecz rozwoju gospodarki wodorowej w Polsce) i unijnych (pakiet aktów prawnych „Fit for 55”). Jednym ze sposobów wykorzystania wodoru do produkcji energii elektrycznej lub cieplnej jest technologia ogniw paliwowych. Umożliwia ona wytwarzanie ww. energii bez emisji szkodliwych substancji, np. pyłów. W dalszej części artykułu przedstawiono stan ogniw paliwowych w Polsce. Omówiono, jakie projekty i działalności podejmują polskie jednostki na rzecz rozwoju technologii ogniw paliwowych w Polsce. Następnie scharakteryzowano rynek urządzeń dla użytkowników domowych. Obecnie rynek tego typu urządzeń dla gospodarstw domowych jest stosunkowo mały. W katalogach producentów znajdują się agregaty prądotwórcze oraz kogeneratory lub mikrokogeneratory. Krótko omówiono dostępne urządzenia: jakie ogniwa paliwowe wykorzystują, jakim rodzajem paliwa są zasilane, jakie są ich parametry eksploatacyjne (tj. moc cieplna, moc elektryczna, sprawność). W dalszej części artykułu przedstawiono sposoby wprowadzania produktów na rynek Unii Europejskiej. Jeśli ogniwa paliwowe i urządzenia je wykorzystujące mają być dopuszczone do obrotu w Unii Europejskiej, muszą spełniać wymagania odpowiednich rozporządzeń i dyrektyw. Wymieniono rozporządzenia i dyrektywy, którym mogą podlegać urządzenia wykorzystujące ogniwa paliwowe. Następnie przedstawiono zagadnienia związane z certyfikacją i badaniami potwierdzającymi właściwości deklarowane dla urządzeń z ogniwami paliwowymi w Laboratorium Badań Urządzeń Gazowych i Grzewczych Instytutu Nafty i Gazu – Państwowego Instytutu Badawczego. Omówiono zagadnienia związane z zakupem generatora energii elektrycznej wykorzystującego stos ogniw paliwowych, a także konfigurację stanowiska pomiarowego przygotowanego na potrzeby prowadzenia badań realizowanych w ramach pracy statutowej. Podano, jakie instalacje oraz ich opomiarowanie są konieczne do prowadzenia badań. Po stronie zasilającej urządzenia z ogniwem paliwowym znajdują się: paliwo, utleniacz (np. powietrze), energia elektryczna potrzebna do rozruchu urządzenia, natomiast po stronie wyjścia: energia elektryczna i cieplna produkowana przez urządzenie, gazy wylotowe oraz woda.
The Effect of Manual Detorsion on Testicular Salvage Rates in Adult Testicular Torsion Patients: Single Center Experience
Authors: VURUŞKAN Ediz , ERÇİL Hakan , KARKİN Kadir , ÜNAL Umut , AKGÜN Ömer Faruk , AYHAN Lokman , ANIL Hakan
Published: June 2022

Aim: The aim of this study was to reveal the effect of manual detorsion on testicular salvage rates and the factors affecting the success of manual detorsion in adult testicular torsion.
Material and Methods: The records of patients who applied to the emergency department with pre-diagnosis of acute scrotum were examined. A total of 62 adult patients diagnosed with testicular torsion were included in the study. Manual detorsion was attempted in all patients before surgery. Demographic characteristics of the patients, time from onset of scrotal pain to hospital admission (<24 hours/>24 hours), physical examination and ultrasonography findings, type of surgery performed, and long-term results were evaluated. The data were statistically compared between patients with manual detorsion considered successful and unsuccessful.
Results: Manual detorsion was considered successful in 36 (58.1%) patients and unsuccessful in 26 (41.9%) patients. Orchiopexy was performed in 35 (97.2%) of the successful patients and in 11 (42.3%) of the unsuccessful patients (p<0.001). When subgroup analysis was performed, although there was no significant difference in pain duration between patients with and without successful manual detorsion for patients with pain duration of less than 24 hours (p=0.648), there was a statistically significant difference in testicular salvage rates. While the rate of orchiectomy was 1/35 (2.9%) in patients with successful manual detorsion, this rate was 8/19 (42.1%) in unsuccessful patients (p<0.001).
Conclusion: Manual detorsion increases testicular salvage rates in adult patients diagnosed with testicular torsion, and it should be attempted especially in patients with pain duration less than 24 hours.
Kindergarten an der Deutschen Schule in Bratislava – ein Elitekindergarten?
Authors: Muzikářová Milina , Ponca Marek
Published: June 2022

Eliteschule wird nicht nur positiv betrachtet, sondern auch negativ. Insgesamt ist es problematisch den Begriff Elite zu charakterisieren und mit Schulen zu verbinden, deshalb haben wir uns die Frage gestellt, ob die DSB als eine Eliteschule bezeichnet werden kann. Im vorliegenden Beitrag beschäftigten wir uns mit dem Spracherwerb in der KiTa, mit dem Soft- CLIL- Ansatz, mit den deutschen Schulen in der Welt, mit dem Qualitätsrahmen. Wir haben uns auf die Deutsche Schule in Bratislava fokussiert. Als Forschungsexperiment wurde ein Interview mit der Kindergartenleiterin der Deutschen Schule in Bratislava angewendet. Wir konzentrierten uns auf die Position der DSB, auf die Ausbildung der Lehrkräfte, didaktische Materialien, auf die Kooperation mit anderen Institutionen, das Profil der Eltern, der Tagesablauf im Kindergarten der DSB und auch den damit verbundenen Spracherwerb, das Inklusionsprozess in der Schule und die tägliche Betreuung der Kinder im Vorschulalter. Es wurde auch die SWOT Analyse angewendet, um die Schwäche und Stärke der Schule festzustellen, also mit den Vorteilen und Nachteilen der DSB in Bratislava.
Temeljne kompetence za poučevanje tujega jezika v zgodnjem otroštvu
Authors: Kacjan Brigita , Šauperl Žiga
Published: June 2022

Članek se ukvarja s temo kompetenc učitelja, ki so potrebne oz. zahtevane za poučevanje tujega jezika v zgodnjem otroštvu. Uvodoma je predstavljen koncept kompetenc, sledi analiza in pregled temeljnih dokumentov na področju poučevanja tujega jezika v zgodnjem otroštvu. Situacija v Sloveniji in po svetu je še vedno dokaj nedorečena oz. nejasna, kar pomeni, da so učni načrti, zakoni in drugi pomembni predpisi in relevantni dokumenti, vezani na osnovne kompetence učiteljev za poučevanje v predšolskem obdobju, dvoumni in niso natančno definirani. Analiza se osredotoča na kompetence, ki so predstavljene v teh dokumentih, kompetence so tako razvrščene v kategorije in podkategorije. Kategorije so razdeljene na tiste, ki so vezane na učenje in učni proces, na tiste, ki so vezane na učenca in na tiste, ki so vezane na učitelja. Po pregledu temeljnih dokumentov nam končni povzetek prikaže široko in raznoliko področje kompetenc, potrebnih za poučevanje tujega jezika v zgodnjem otroštvu, kar se precej razlikuje oz. hkrati dopolnjuje in nadgrajuje že tako obsežne zahteve splošnega poučevanja tujega jezika.
Ravnanja in stališča učiteljic tujih jezikov v kontekstu poučevanja v predšolskem obdobju
Authors: Lipavic Oštir Alja , Foršek Mojca , Škafar Bernarda
Published: June 2022

V prispevku poskušamo odgovoriti na vprašanje, kako učiteljice tujih jezikov premagujejo ovire, ki jih zanje predstavlja poučevanje tujega jezika v vrtcu, in katera stališča do tega poučevanja pri tem razvijajo. V ta namen smo izvedle intervjuje z učiteljicami tujih jezikov, ki imajo večletne izkušnje s poučevanjem tujih jezikov v vrtcih. Kvalitativna analiza intervjujev nam je omogočila vpogled v izzive, težave in rešitve, ki se nujno pojavljajo zaradi izobrazbe učiteljic oz. pomanjkanja ustreznih kompetenc po končanem študiju tujih jezikov. Obenem je pokazala tudi odnos do samega področja dela ter omogočila vpogled v prakso poučevanja. V analizi je bilo mogoče identificirati naslednje teme: sprememba paradigme dela, oblikovanje in izvedba pouka, prednosti in slabosti zgodnjega poučevanja, delo z zgodnje večjezičnimi otroki ter poklicni profili in poučevanje tujih jezikov v predšolskem obdobju. Intervjuji so pokazali, da se postopoma izrisuje oblika sodelovanja med učiteljicami oz. učitelji tujih jezikov in vzgojiteljicami oz. vzgojitelji, kar pa je pogojeno z zavedanjem o pomembnosti medsebojnega sodelovanja tako vsebinsko glede na obravnavane teme kot tudi glede na profesionalni razvoj tistega, ki poučuje. To zavedanje se oblikuje na ozadju dodatnega izobraževanja po končanem študiju.
Application of Chatbot at a Higher Education Institution in Republic of Serbia
Authors:   Belgrade Business and Arts Academy of Applied Studies, Republic of Serbia, Matić Rade , Kabiljo Miloš ,   Belgrade Business and Arts Academy of Applied Studies, Republic of Serbia, Deretić Nemanja ,   Belgrade Business and Arts Academy of Applied Studies, Republic of Serbia, Vukomanović Aleksandar ,   Belgrade Business and Arts Academy of Applied Studies, Republic of Serbia
Published: June 2022

A chatbot is an algorithm, a programming script, designed to give users the ability to communicate and interact with it online in order to perform a specific task, without any human factor involvement. In the beginning, chatbots were exclusively programs with which it was possible to correspond by exchanging instant text messages. The main focus of the paper is on the presentation of usage of chatbot ADA (Academic Digital Assistant) based on artificial intelligence. ADA chatbot was developed to provide students with an enhanced study service and the necessary information during their studies. Statistical parameters of the use of chatbot ADA and the analysis of statistics of conversations by channels show growing trend in the use of chatbots in all three surveys of communication channels (Viber, FB Messenger and Website). The conclusions of the analysis of top 10 scenarios and number of conversations are shown that students' interests were in accordance with the school calendar and obligations.
Analiza rabe vode, vrednosti investicij in tekoči izdatkov za varstvo okolja v predelovalni dejavnosti v Sloveniji (2013-2020)
Authors:   Institut A-STAT d.o.o., Ljubljana, Slovenia, Moretti Melita
Published: June 2022

The study aimed to examine water use, investment value, and current expenditure for environmental protection in the manufacturing sector in the run-up to the COVID-19 pandemic (from 2013 to 2019) and in 2020, when the pandemic started. The analysis included all manufacturing enterprises in Slovenia that used industrial water (water for production and cooling) between 2013 and 2020. We found that, between 2013- 2019 (before the COVID-19 pandemic) and 2020, there was a statistically significant decrease in the use of fresh drinking water (p=0.043) and recycled water (p=0.044), as well as a statistically significant increase in wastewater management expenditure (p=0.046) and current expenditure for the protection and improvement of soil, groundwater and surface water (p=0.032). Worryingly, the enterprises showed statistically significant decreases in expenditure for research and development in environmental protection (p=0.037).
Vpliv inovacijske uspešnosti podjetij na področju trajnostne in učinkovite rabe vode na njihovo poročanje
Authors:   Institut A-STAT d.o.o., Ljubljana, Slovenia, Moretti Melita
Published: June 2022

This paper presents the findings of a survey conducted in 212 manufacturing enterprises in Slovenia that used industrial water. We wanted to identify the potential impact of innovation performance in sustainable and efficient water use on water management reporting. Our analysis found that innovations in the organizational system contributed the most to corporate reporting on sustainable and efficient water management (B=0.824; p<0.001). Reporting on sustainable and efficient water management in these companies was also influenced by innovation performance in materials and technological processes (B=0.781; p<0.001). Both were strong and positive influences.
The Impact of Lessons Addressing Sustainability on Vocational College Students’ Attitudes Towards Sustainability
Authors:   RWTH Aachen University, Faculty of Business and Economics, Aachen, Germany, Paape Björn , Maus Christoph ,   RWTH Aachen University, Faculty of Business and Economics, Aachen, Germany, Kiereta Iwona ,   RWTH Aachen University, Faculty of Business and Economics, Aachen, Germany, Dambietz Laura ,   RWTH Aachen University, Faculty of Business and Economics, Aachen, Germany, Gnacke-Hötzel Sophie ,   RWTH Aachen University, Faculty of Business and Economics, Aachen, Germany, Sollich Nicole ,   RWTH Aachen University, Faculty of Business and Economics, Aachen, Germany, Trott Alicia ,   RWTH Aachen University, Faculty of Business and Economics, Aachen, Germany
Published: June 2022

The great importance that topics such as environmental protection and sustainability currently have for teenagers cannot be ignored. In addition to the Fridays for Future movement, the Shell Youth Study also confirms the personal involvement of young people with regard to the issue of sustainability. Recently conducted studies have demonstrated the immense influence of school on students and their attitudes towards sustainability. The combined effect of this positive impact of school lessons and the high level of personal involvement of teenagers or students regarding the topic of sustainability reveals a research topic that is addressed in the study at hand. Hereby, the focus lies on a group of students that is often overlooked in this context: students in vocational colleges. Using a survey consisting of 39 participants, the effect that teaching the topic of sustainability has on their attitudes towards this topic was investigated. To this end, two differently de-signed lessons were taught. The lesson concepts differ in their orientation: within the first one, the students dealt with sustainability from a consumer perspective; in the other, they dealt with sustainability from a company perspective. The evaluation of the questionnaires based on differently oriented dilemmas was carried out by means of a Wilcoxon signed-rank test.
Challenges Of Disaster Risk Reduction Knowledge: The Case Study of Floods
Authors:   University of Belgrade, Faculty of Organizational Sciences, Belgrade, Serbia, Radaković Jelena Andreja , Makajić-Nikolić Dragana ,   University of Belgrade, Faculty of Organizational Sciences, Belgrade, Serbia, Petrović Nataša ,   University of Belgrade, Faculty of Organizational Sciences, Belgrade, Serbia, Ćirović Marko ,   University of Belgrade, Faculty of Organizational Sciences, Belgrade, Serbia, Milenković Nemanja ,   University of Belgrade, Faculty of Organizational Sciences, Belgrade, Serbia
Published: June 2022

In the last 50 years of human development, waterrelated hazards have been dominating among the disasters, that have caused both human casualties and economic damage. Floods are among the top ten worst types of natural disasters, positioning on an unenviable third place, when taking in account, above all, the number of human lives that have been lost. Unfortunately, forecasts show that the negative trend of flood impact will continue to grow, mainly as a result of climate change, population growth and economic development. For these reasons, the need for implementing Disaster Risk Reduction has been recognized globally as a way to reduce the risk and impact of all natural disasters, including floods. On top of this, the need to include education in this area is also recognized, especially in the field of knowledge-based decision-making process. When it comes to Disaster Risk Reduction knowledge, it should be noted that despite the efforts related to the wider implementation of this type of education, practice shows that it is still been poorly represented at all necessary levels of formal and non-formal education, although in the Sendai Framework for Disaster Risk Reduction 2015–2030 precisely emphasizes the critical role of knowledge in Disaster Risk Reduction.
Ocenjeno ekonomsko breme demence v obodobju 2015-2018 ter prilagoditev delovnega okolja v organizacijah
Authors:   National Institute of Public Health, Ljubljana, Slovenia, Sedlak Sabina , Jelenc Marjetka ,   National Institute of Public Health, Ljubljana, Slovenia
Published: June 2022

Due to demographic changes, dementia will be a major public health challenge in the society of the future. However, dementia is a challenge and a great burden for employers as well. This area is becoming important from the work organization point of view. Health problems caused by early dementia also lead to premature retirement. Direct and indirect costs are burden for employers and the health system. The National Institute of Public Health analyzed the economic burden of dementia in Slovenia in the period 2015-2018. The economic burden of dementia represents 0.3% of all health expenditures or 0.05% of GDP in the study period. Upgraded and multidisciplinary solutions are needed, as well as an adapted and stimulating environment for people with dementia. Improved well-being and the behavioral and mental state of people with dementia in both the work and home environment, consequently, also brings favorable financial effects to employers and the state.
Weed Dynamics, Growth, Yield and Correlation Study as Affected by Weed Control Methods in Soybean [Glycine max (L.) Merril.]
Authors: Barla Sheela , Binjha K.K. , Upasani R.R.
Published: June 2022

Background: Soybean being a rainy season crops, is heavily infested with weeds thus ultimately affect the crop yield and economic return. Methods: Field experiment was conducted at Birsa Agricultural University, Ranchi during rainy season of 2019 and 2020 under randomized block design replicated thrice with eight different weed control methods viz., imazathapyr 75 g/ha at 20 days after sowing (DAS), imazathapyr 35% + imazamox 35% ready mix (RM) 75 g/ha at 20 DAS, quizalofop ethyl 50 g/ha at 20 DAS, sodium acifluorfen 16.5% + clodinafop propargyl 8% (RM) 125 g/ha at 20 DAS, imazathapyr 2% + pendimethalin 30% (RM) 1 kg/ha at 20 DAS, hand weeding at 20 and 40 DAS, weed free (three hand weeding at 20, 40 and 60 DAS) and weedy check. Result: Among herbicides, application of quizalofop ethyl 50 g/ha recorded higher growth and yield attributes of soybean due to reduced weed density and weed dry matter which resulted in higher weed control efficiency, weed management index, agronomic management index, thereby recorded maximum soybean yield (2065 kg/ha), net return (₹ 54,743/ha) and B:C ratio (2.50). The soybean yield was negatively correlated with weed dry matter particularly with grassy as well as total weed dry matter while plant dry matter accumulation was strongly correlated with soybean yield.
Role of Osmotic Regulation and Cryoprotectant Substances in the Freezing Tolerance of Alfalfa in Cold, Dry Conditions
Authors: Xu Hongyu , Li Yuying , Zhong Hua , Li Xianglin
Published: June 2022

Background: Freezing temperatures are a limiting factor hindering the survival of alfalfa (Medicago sativa L.) through winter. Soil drought also damages alfalfa crowns and can affect their regeneration. Therefore, it is important to determine the effects of cold, dry conditions on alfalfa to develop effective water management strategies in winter. Methods: Cold, dry conditions were established in the laboratory and the freezing tolerance of crowns was compared between the alfalfa cultivars ‘WL440HQ’ and ‘ZhaoDong’. The degree of freezing tolerance was estimated on the basis of relative electrolyte leakage and semi-lethal temperature. The effects of cold, dry conditions on alfalfa crowns were determined by investigating the rate of water loss and the concentrations of soluble sugars (which function as cryoprotectants) and betaine and proline (which function as osmoregulation substances). Result: Compared with crowns of ‘ZhaoDong’, those of ‘WL440HQ’ showed a higher water loss rate in cold, dry conditions and were irreversibly damaged and their freezing tolerance was severely affected. In comparison, crowns from ‘ZhaoDong’ showed a lower water loss rate and lower relative electrolyte leakage under cold, dry conditions and their freezing tolerance was not significantly affected. The higher water loss rate and lower freezing tolerance were the direct causes of death of ‘WL440HQ’, the cultivar with a higher fall dormancy score. In cold, dry conditions, the content of proline, an osmotic regulation substance, increased in response to soil water deficit and may have improved the ability to withstand freezing temperatures by preventing rapid water loss. In addition, sucrose, fructose, galactose and stachyose contents in the crown increased under cold, dry conditions and may have enhanced freezing tolerance because of their function as cryoprotectants. The results of this study indicate that maintaining soil moisture within the range suitable for the growth of crowns is important for the successful overwintering of alfalfa.
The Effectiveness of Training Based on Cognitive-Emotional Mediation on Increasing Mothers’ Interactive Literacy and Improving Preschool Children’s Metacognition
Authors: Poortaheri Forough , Yazdi Seyed Amir Amin , Kareshki Hosein , Rahimi Mehdi
Published: June 2022

This study was conducted with the aim to design a parenting training program based on cognitive-emotional mediation and evaluating the effectiveness of this program on increasing mothers’ literacy of interaction and children’s cognitive modifiability in the field of metacognition and theory of mind. The curriculum was designed with a combination of parenting implications of mediated learning experience theory, developmental, individual differences relationship-based approach, and metacognitive approach. Twenty-five pairs of mother and child participated in the study voluntarily. The children were in the preschool age range (4–6). Mothers learned how to use mediation in daily interactions during 12 sessions of group theoretical training and one session of individual practical training. At the end of the training program, the mothers’ literacy of interaction and the children’s metacognition and theory of mind were assessed. The results of repeated measures-analysis showed that mothers’ participation in the training program increased their literacy of interaction in four dimensions of communication, emotional, cognitive, and sending fundamental love messages. In addition, the implementation of training programs for mothers led to children’s cognitive modifiability in the areas of planning, working memory, metacognition, and theory of mind.
Specificities of Work of Railway Permanent Way in Conditions of Continuous Winter Period
Authors: Bel'tyukov Vladimir , Andreev Andrey
Published: June 2022

Purpose: To determine legitimacies of changes in technical state of railway permanent way in the areas with harsh climate conditions with the purpose to design track maintenance system in the Arctic conditions. Methods: During the study, an analysis of main indicators of permanent way (upper construction) technical condition was carried out such as the way’s element defectiveness (rails, fastenings, sleepers, ballast pollution) and faults of geometric parameter norms of rail track (widenings and narrowings, alignment by a level, sags, subsidences, position in a plan). Data analysis was carried out in accordance with specially created model of the dependence of changes in the parameters of permanent way technical condition from a workload tonnage inclusive of annual periods. Results: Based on the observations, the change in track maintenance costs for the lines located in continuous winter conditions was determined. These are costs, related to railway track faults and defectiveness of track superstructure (permanent way) elements. Practical importance: The results of the study ‘re intended for the work planning system development on track maintenance and repairs in harsh climate conditions.
Influence of Thermomechanical Workload on the Aging of Insulation of Traction Electric Motors of Diesel Locomotives
Authors: Shrayber Marina
Published: June 2022

Purpose: To consider the problem of increasing the reliability of traction electric machines. To assess the effect of thermomechanical stresses on the service lifetime of insulating material of traction electric motors. Methods: Finite element method, implemented in SolidWorks 2005 software package, was chosen as the main method for studying and calculating temperature fields. Results: The results show that thermomechanical stresses play a significant role during dynamic thermal aging of stator winding insulation system. With dynamic temperature changes, an insulation system experiences repeated thermomechanical stresses since the coefficients of thermal expansion of insulating materials and copper conductors are different. Practical importance: The need for further study of the actual thermal state of electrical machines has been identified which will allow to a rise temperature definition accuracy, to give a warning for possible overheating in operation by that extending traction motor lifetime and reducing sudden failure likelihood. The developed methods for determining electrical machine thermal state are recommended for practical use.
Preparation of Water Cadastre Publications on the Arctic Zone of the Russian Federation as a Constituent of Technosphere Safety Support
Authors: Tret'yakov Mihail , Piskun Aleksandr , Terehova Raisa
Published: June 2022

Purpose: To assess the state and to identify the problems of preparing materials for the publication of the Water Cadastre for the Arctic zone of the Russian Federation. Methods: Analysis of information received by the Arctic and Antarctic Research Institute from the Murmansk, Northern, Ob-Irtysh, Central Siberian, Yakutsk and Chukotka hydrometeorological departments. Results: It is shown that the state of preparation of the Water Cadastre publications and the quality of published observations on the territory of the Arctic zone of the RF do not meet set regulatory requirements. This negatively affects the results of engineering calculations for hydrological support of economic activity in the region and, as a result, may reduce the level of technospheric safety in the Arctic. Practical significance: The results obtained made it possible to formulate the requirements for improving work efficiency in the preparation of publications of the Water Cadastre for water objects of the RF Arctic zone.
Innovative Structural-Heat-Insulating Concrete for Insulation and Stability Rise of Frozen Foundation Soils
Authors: Stepanova Irina , Abu-Hasan Mahmud , Solov'eva Valentina
Published: June 2022

Purpose: To create highly effective heat-insulating structural concrete, recommended for insulating and preventing permafrost soil thawing. Methods: When conducting research, we used GOST (Russia State Standards) 25820-2014 “Lightweight concrete. Specifications”, GOST 25485—2019 “Cellular concrete. General technical conditions”. Determination of strength and processing of results according to GOST 10180-2012 “Concrete. Methods for determining strength upon control samples”; thermal conductivity coefficient was determined according to GOST 7076-99 “Construction materials and products. Method for determining thermal conductivity and thermal resistance at stationary thermal regime”; frost resistance of concrete according to GOST 10060-2012 “Concrete. Methods for determining frost resistance”; density of concrete in natural moisture state- according to GOST 12730.1-2020 “Concrete. Density determination methods”. It has been established experimentally that in order to create highly efficient heat-insulating-structural concrete, it is advisable to use as a filler a foam glass of fraction 1.25–2.5 mm, D250, λ ≈ 0.06 W/ m · °C, and for to create strong and reliable matrix on cement basis it’s effective to use finely dispersed microsilica in combination with complex chemical additive on polycarboxylate basis, modified with nano-dispersions of silicon dioxide, SiO2. Results of physicalmechanical studies have confirmed that it is effective to use particles of silicon dioxide together of micro- and nano-size in combination with surfactants represented by polycarboxylate polymers, meanwhile, foamed glass concrete with the best compressive strength and tensile strength at bending a rises significantly, coefficient of resistance to cracks of nanomodified foam glass concrete, Ktr. = Rbend./Rcompress. = 3.6/13.3 = 0.27, has rather high value which should provide for increased resistance to cracks and for reliability for a protective coating. In order to increase density/strength without deteriorating heat-insulating indicators it is advisable to use additionally a finely-ground blast-furnace slag as a filler which a rises cohesion of foam glass concrete mixture and strength of foam glass concrete. Practical significance: Rational ratio of components of nanomodified foam glass concrete mixture ensures the creation of highly mobile foam glass concrete mixture with good workability, and on the mixture basis, a unique heat-insulating-structural material is formed with the following characteristics: D900; λ = 0.14 W/m·°C, B12, Btb2.9 F1300 that defines it as a thermal insulation material of increased reliability and durability, which is advisable for recommendation for the Arctic harsh regions.
Features of Construction Calculation on Frequent Weak Earthquake Impact
Authors: Uzdin Aleksandr , Benin Andrey , Nazarova Shohista , Sabirova Oyposhsha , Belashov Mihail
Published: June 2022

Purpose: To show the features of the calculation of constructions in opposition to the effect of weak frequent earthquakes. Methods: Numerical modeling of seismic vibrations of constructions. Analysis of limit states. Results: The specificities of construction calculation for impact of weak earthquakes are analyzed. Earthquakes of 1 per 30 and per 50 years repeatability are considered. In the first case, after an earthquake a construction should operate standardly, without damage. In the second case, damages, that does not affect construction exploitation, are accepted. Main attention is paid on the three issues: setting of elastic and damping characteristics of ferroconcrete, formalization of limit states, load combinations. The dependence of a damping from ferroconcrete reinforcement degree is estimated. When evaluating limit states, besides calculations on crack resistance and strength, the possibility to exclude people panic is considered. To make so, it’s proposed to limit speed level in certain octave ranges. Proposals are developed for estimation of coefficients for combinations of various loads with seismic ones. The coefficients for combinations of seismic and ice loads are evaluated. Practical importance: A system of calculating coefficients has been established to assess seismic resistance under relatively weak, frequent impacts. It’s been shown that for strong impacts, the combination coefficients for different regions turn out to be close to each other, while for weak impacts, they can differ drastically.
Why Does Doxycycline Pose a Relatively Low Risk for Promotion of Clostridioides difficile Infection?
Authors: Xu Dongyan , Mana Thriveen , Cadnum Jennifer , Deshpande Abhishek , Afsari Faezeh , Sangwan Naseer , Donskey Curtis
Published: June 2022

Background:  Clinical studies suggest that doxycycline poses a low risk for promotion of Clostridioides difficileinfection, but the microbiologic explanation for this finding is unclear. 
Methods:  Mice treated with oral doxycycline, oral azithromycin, subcutaneous ceftriaxone, doxycycline plus ceftriaxone, or azithromycin plus ceftriaxone were challenged with 104 colony-forming units of 2 different C. difficilestrains on day 2 of 5 of treatment. The concentration of C. difficile was measured in stool 2 and 5 days after challenge. The impact of the treatments on the microbiota was assessed by sequencing.
 Results:  Doxycycline and azithromycin treatment did not promote colonization by either C. difficile strain in comparison to saline controls. Doxycycline treatment significantly reduced ceftriaxone-induced overgrowth of a C. difficile strain with doxycycline minimum-inhibitory concentration (MIC) of 0.06 µg/mL (P<0.01) but not a strain with doxycycline MIC of 48 µg/mL (P>0.05); azithromycin treatment did not reduce ceftriaxone-induced overgrowth of either strain. 16S rRNA amplicon sequencing revealed significantly lower bacterial diversity in the stool of ceftriaxone-treated mice, in comparison to doxycycline-treated and azithromycin-treated mice.
Conclusions:  These findings suggest that doxycycline may have a low propensity to promote C. difficile colonization because it causes relatively limited alteration of the indigenous microbiota that provide colonization resistance and because it provides inhibitory activity against some C. difficile strains.
The World as Police
Authors: Trafford James
Published: June 2022

This article argues that colonial modernity birthed the police as a world-shaping force that came to define both civil society and the world itself.
Being Earth: The Culture of Nature in a Post-Holocene World
Authors: Weishaus Joel
Published: June 2022

How do we gain a sane footing on a planet we’ve spent thousands of years as a geophysical bully wielding ever more clever tools and powerful machines in a mad quest for total domination?
Christine Daigle and Terrance H. McDonald (eds.), From Deleuze and Guattari to Posthumanism: Philosophies of Immanence
Authors: Vangeest Jacob
Published: June 2022

A review of From Deleuze and Guattari to Posthumanism: Philosophies of Immanence, edited by Christine Daigle and Terrance H. McDonald
A patient with relapsed high-grade serous ovarian carcinoma with somatic RAD51C mutations treated with PARPi monotherapy: a case report
Authors: Ngu Siew-Fei , Ngan Hextan Y. S. , Chan Karen K. L.
Published: June 2022

We report our experience in the management of a relapsed ovarian cancer patient with somatic RAD51C mutation, treated with olaparib monotherapy. The patient was diagnosed with stage 4 high-grade serous ovarian carcinoma and was treated with neoadjuvant chemotherapy, cytoreductive surgery, and postoperative chemotherapy. After a second cancer recurrence, she underwent FoundationOne CDx testing following disease progression on multiple lines of chemotherapy. Based on the FoundationOne CDx results, olaparib monotherapy was started. After 13 months of therapy, all lesions responded to the treatment, and she achieved complete response as demonstrated by normalization of the levels of CA125 and positron emission tomography-computed tomography (PET-CT). We plan to continue olaparib monotherapy until disease progression.
AdipoRon and Pancreatic Ductal Adenocarcinoma: a future perspective in overcoming chemotherapy-induced resistance?
Authors: Sapio Luigi , Ragone Angela , Spina Annamaria , Salzillo Alessia , Naviglio Silvio
Published: June 2022

The latest scientific knowledge has provided additional insights accountable for the worst prognosis for pancreatic ductal adenocarcinoma (PDAC). Among the causative factors, the aptitude to develop resistance towards approved medications denotes the master key for understanding the lack of improvement in PDAC survival over the years. Even though several compounds have achieved encouraging results at preclinical stage, no new adjuvant agents have reached the bedside of PDAC patients lately. The adiponectin receptor agonist AdipoRon is emerging as a promising anticancer drug in different cancer models, particularly in PDAC. Building on the existing findings, we recently reinforced its candidacy in PDAC cells, proposing AdipoRon either as a suitable partner in gemcitabine-based treatment or as an effective drug in resistant cells. Crossing the current state-of-the-art, herein we provide a critical perspective on AdipoRon to figure out whether this receptor agonist can potentially be considered a future therapeutic choice in overcoming chemotherapy-induced resistance, expressly in PDAC.
Stigma Sosial Pengangguran di Media Daring Amerika Serikat pada Masa Pandemi COVID-19
Authors: Evanytha  , Farady Marta Rustono , Panggabean Hana , Amanda Mercedes
Published: June 2022

The social stigma of unemployment during the COVID-19 pandemic related to problems of marginalization. This study explores the construction of the meaning of the social stigma of unemployment in United States online media. This study is a comparative study to compare the construction of the meaning of social stigma between online media usa.today and nbcwashington.com with Entman's framing analysis. The problem formulated through framing is that social stigma makes it difficult for unemployed people to get a job, and stigma creates feelings of inferiority. The cause of the social stigma is the perception of low personal qualities and stigma consciousness. Framing moral judgment is a negative perception in employers' minds and the feeling of shame due to unemployment. Countermeasure suggestion is a wide distribution of vaccines and suggestions about ways to find work. Online media can contribute as agents of change through news framing to improve public perceptions and provide informational support.
The DARPin Encyclopedia: from Basic Research towards Therapeutics
Authors: Wild Philipp , Eapen Rohan , Forrer Patrik , Jost Christian
Published: June 2022

The adaptive immune system in vertebrates comes in two flavors. Historically, adaptive immunity focused on the study of immunoglobulins (also referred to as Ig-based antibodies herein); more recently, jawless vertebrates were found to use an entirely different class of proteins for their adaptive immunesystem. Specifically, these organisms express variable lymphocyte receptors (so called VLR antibodies) that create diversity based on the rearrangement of leucine-rich repeats. Meanwhile, various, naturally occurring repeat motifs have been used as building blocks for the design of artificial binding scaffolds which, among others, include designed ankyrin repeat proteins (DARPins). Such binding scaffolds are also referred to as non-Ig-based antibodies or non-Ig scaffolds herein). DARPins display several benefits such as a low molecular weight (~15 kDa), high thermal stability, high specificity and affinity, versatility (e.g., in terms of valency and multi-specificity), speedy preclinical development, low production costs and, thus, bear the potential to not only complement existing therapeutic Ig-based antibodies but also open up novel therapeutic strategies. The first generation DARPin therapeutic abicipar pegol has completed two Phase III studies in 2020 while several other DARPin drug candidates are currently undergoing clinical validation. Most recently, the rapid development of tri-specific SARSCoV-2 DARPin therapeutics showcases the immense potential of recombinant repeat proteins in adopting quickly e.g., new forms of target neutralization that a single Ig-based antibody cannot afford. Here, we highlight the design principles of repeat proteins in general and summarize in detail the continuous advancements of the DARPin scaffold that made it one of the most promising antibody mimetics to date. This review provides an overview of current and emerging applications of DARPins as both a research tool and therapeutic drug that can match or even surpass Ig-based antibody applications.
The Mechanism of Methylmercury Permeation Through the Blood-Brain Barrier using Caenorhabditis elegans
Authors: Jaffery Zehra
Published: June 2022

Methylmercury is a neurotoxin present in fish tissues that permeates the blood-brain barrier after consumption. Previous research has shown that methylmercury is harmful to neurons, causing pH alterations, oxidative stress, excitotoxicity, and parenchymal damage. Methylmercury is a known factor of neurological disorders including Alzheimer's and Parkinson's. The method by which methylmercury passes through the blood-brain barrier is largely unknown. According to preliminary studies, one way methylmercury crosses the blood-brain barrier is by creating a complex with L-Cysteine, which facilitates its passage by the LATs system through mimicking another amino acid existing in the body. The human blood-brain barrier was studied using C. elegans as a model organism. It was hypothesized that if methylmercury passes through the blood-brain barrier of C. elegans faster with L-Cysteine present than without L-Cysteine present, the methylmercury's adverse effects (death and locomotive difficulty) will occur sooner. Each of the four experimental groups contained one C. elegans: the control, the L-Cysteine group, the methylmercury group, and the methylmercury and L-Cysteine combination group. The effects of L-Cysteine and methylmercury on C. elegans were studied using three metrics: viability, locomotive disability, and time for locomotive effects to occur. The group that received both methylmercury and L-Cysteine had reduced viability rates and a decreased time for locomotive difficulty to develop, supporting the hypothesis. These findings suggest that L-Cysteine aids methylmercury permeation through the blood-brain barrier. Because the experiment indicates how methylmercury penetrates the blood-brain barrier, these results aid in finding a therapeutic solution to reverse methylmercury neurotoxicity in the brain. Additionally, this study further opens channels into potential therapeutic and preventative measures for dementia, improving morbidity and mortality in neurodegenerative diseases.
Qualitative Analysis of Water Contents in The Refill Drinking Water Depot Of Giripurno Village, Bumiaji, Batu
Authors: Wati Peni Ambar , Priyanto Anugerah Dany , Silaban Yehezkiel Flobert , Ganendra Devara Priya
Published: June 2022

Indonesia Central Statistics Agency shows that refilled water will be the main source of drinking water that is most widely used by households in Indonesia in 2020. In particular, people who live close to clean water sources such as Giripurno Village, Bumiaji District, Batu City feel that bottled water is getting more expensive, so that another alternative is emerging, namely drinking water produced by Water Depot Refilling Station (DAMIU), which is more affordable, but the quality is unknown. Therefore, drinking water at the refill drinking water depot is analyzed based on physical, chemical, and microbiological aspects to see the feasibility of refilled drinking water in accordance with PERMENKES No. 492 of 2010 about Drinking Water Quality Requirements. Drinking water samples were taken once at the refill drinking water depot. The results of laboratory analysis of drinking water are measured in terms of physical, chemical and microbiological parameters according to the Indonesian National Standard (SNI) method. The results of the analysis of the DAMIU in Giripurno Village sourced from the Kijan Spring is accordance with the PERMENKES RI Number 492/MENKES/PER/IV/2010 except for Coliform levels, so further research needs to be done to eliminate excessive Coliform levels.