bluuebunny/crossref_metadata_2025 huggingface dataset:
Correction to: Idealness of k-wise intersecting families
Authors: Abdi Ahmad , Cornuéjols Gérard , Huynh Tony , Lee Dabeen
Published: February 2022

A Correction to this paper has been published: 10.1007/s10107-020-01587-x
“Near-TME”: proposed standardisation of the technique for proctectomy in male patients with ulcerative colitis
Authors: Garcia-Granero A. , Pellino G. , Fletcher-Sanfeliu D. , Millan M. , Primo-Romaguera V. , Garcia-Gausí M. , Fernandez M. , Gonzalez-Argente X. , Spinelli A. , Valverde-Navarro A. , Garcia-Granero E.
Published: February 2022

Background

The aim of the present study was to describe in detail an approach to proctectomy in ulcerative colitis (UC), which can be standardized; near-total mesorectal excision (near-TME), to prevent injuries to autonomic pelvic nerves and subsequent sexual dysfunction.

Methods

We demonstrate the technique ex vivo on a cadaver from a male patient in lithotomy position and on a sagittal section of a male pelvis. We also demonstrate the technique in vivo in two male patients diagnosed with UC, with no history of sexual dysfunction or bowel neoplasia. The study was performed at the Human Embryology and Anatomy Department. University of Valencia, Spain.

Results

The posterolateral dissection during a near-TME is similar to that of an oncologic TME, whereas the anterolateral is similar to that of a close rectal dissection. The near-TME technique preserves the superior hypogastric plexus, the hypogastric nerves, the nervi erigentes, the inferior hypogastric plexus, the pelvic plexus and the cavernous nerves.

Conclusion

The near-TME technique is the standardisation of the technique for proctectomy in male patients with ulcerative colitis. Near-TME requires experience in pelvic surgery and an exhaustive knowledge of the embryological development and of the surgical anatomy of the pelvis.
Exception Sets of Intrinsic and Piecewise Lipschitz Functions
Authors: Leobacher Gunther , Steinicke Alexander
Published: February 2022

We consider a class of functions defined on metric spaces which generalizes the concept of piecewise Lipschitz continuous functions on an interval or on polyhedral structures. The study of such functions requires the investigation of their exception sets where the Lipschitz property fails. The newly introduced notion of permeability describes sets which are natural exceptions for Lipschitz continuity in a well-defined sense. One of the main results states that continuous functions which are intrinsically Lipschitz continuous outside a permeable set are Lipschitz continuous on the whole domain with respect to the intrinsic metric. We provide examples of permeable sets in$${{\mathbb {R}}}^d$$Rd, which include Lipschitz submanifolds.
An analytical model for pressure behavior in multilayered radially composite reservoir with formation crossflow
Authors: Viana Isabela , Bela Renan Vieira , Pesco Sinesio , Barreto Junior Abelardo
Published: February 2022

The present work proposes an analytical model to calculate the pressure response for multilayered radially composite reservoirs considering the presence of formation crossflow along with all layers. The behavior of pressure transient during production tests in radially composite multilayered reservoirs with non-communicating layers has been widely studied, however there is still a lack of studies considering communicating layers, i.e., formation crossflow in such a model. In that sense, the main purpose of this work is to develop a novel analytical solution that can be used to accurately analyze production tests conducted in multilayered radially composite reservoirs considering communicating layers and multiple regions that can have different radii. An infinite reservoir is considered and the properties for each layer, such as permeability, oil viscosity, and porosity may be different. Moreover, the mathematical formulation for this model is presented in the Laplace domain and the Stehfest Algorithm is used to convert the pressure variation into the real-time domain. The results presented in this work show a close agreement when compared to the responses provided by a commercial flow simulator based on finite differences.
Tracking Repeat Victimisation After Domestic Abuse Cases Are Heard With and Without Independent Domestic Violence Advisors (IDVAs) in an English Magistrate’s Court
Authors: Ross John , Sebire Jaqueline , Strang Heather
Published: February 2022

Research Question

Do cases heard in a specialist domestic abuse (SDA) court on days when Independent Domestic Violence Advisors (IDVAs) are present to engage with victims, compared to cases heard on days when no IDVAs are present, result in more convictions, or less frequency or severity of repeat victimisation?

Data

This analysis included all 559 trials in one SDA court from June 2016 to December 2018, including 514 unique victims. IDVAs were present on the starting day of 84% of the trials, leaving 16% (90) cases to start on days when no IDVAs were present.

Methods

The treatment and comparison cases were compared for similarity of 23 characteristics, with only one difference of over 20%. The analysis proceeded as appropriate for a Level 4 (Sherman et al., Preventing crime: What works, what doesn’t, what’s promising: A report to the United States Congress, National Institute of Justice, 1997) quasi-experimental comparison between the treatment and comparison cases.

Findings

IPA trials in the IDVA treatment group were 12% less likely than those in the comparison group to result in a conviction (RR=0.88, 95% CI 0.74-1.05). Trials in the IDVA treatment group had a 96% higher risk of being followed by a repeat domestic abuse incident in the 18 months after trial than trials in the no-IDVA comparison group (RR = 1.96, 95% CI 1.19–3.23). Treatment group victims experienced a mean harm score for repeat victimisation in the 18 months post-trial eight times higher than the comparison group (80 compared with ten).

Conclusions

The provision of Independent Domestic Violence Advisors in a specialist domestic abuse court was clearly correlated with higher rates of repeat victimisation, as well as higher levels of harm in repeat offences and lower rates of conviction. This correlation could well be causal, but only a randomised controlled trial can rule out that possibility.
Schnittstellen in der Versorgung am Lebensende
Authors: Ateș Gülay , Jaspers Birgit , Brunsch Holger , Radbruch Lukas
Published: February 2022

Zusammenfassung. Schnittstellen stehen oft im Zusammenhang mit einer hohen Symptomlast, einem stetig wachsenden Versorgungsnetz und / oder einem häufigen Wechsel zwischen ambulanter und stationärer Versorgung. Schnittstellenproblematiken treten auf der Organisations-, Kommunikations-, Informations- und Wissensebene sowie beim Vernetzen von Institutionen auf. Hinweise auf Versorgungsdefizite am Lebensende und inwiefern eine nicht gelingende Symptomlinderung oder ein häufiger ambulanter und stationärer Versorgungswechsel abgefedert werden kann, wird anhand von Studienergebnissen erörtert. Am Lebensende sind offene empathische Gespräche, Symptomlinderung, psychosoziale Unterstützung und gegebenenfalls die Adressierung spiritueller Fragen bei bedarfsgerechter Anbindung an Einrichtungen und Dienste wichtige Grundpfeiler für Sterbende und Hinterbliebene. Ein Einblick in die unterschiedlichen hospizlichen und palliativen Versorgungsangebote im ambulanten und stationären Bereich, die mit ihren Angeboten auch Hinterbliebene mit einbeziehen, rundet diesen Beitrag ab.
Well-Being and Resources of Minors With Refugee Background in	Comparison to Minors With Migration or Native Background
Authors: Schmees Pia , Braig Johanna , Nilles Hannah , Kerkhoff Denise , Demir Zeynep , Rueth Jana-Elisa , Lohaus Arnold , Eschenbeck Heike
Published: February 2022

Abstract. Background: Studies on the health of minors with refugee background (RM) often focus on symptoms and risks. In contrast to these deficit-oriented approaches, the present study examined well-being and resources of RM. Aims: The aim was to get an overview of the extent to which RM differ from both minors with migration (MM) as well as native (NM) background regarding well-being and resources. In addition, the study sought to identify resources of RM that are significant for well-being. General personal and social resources, religious identity and practice as well as multicultural resources (bilingualism, ethnic identity) were examined. Method: The study was conducted in Germany with minors aged 8–16 years. RM ( n = 209), MM ( n = 535) and NM ( n = 858) completed questionnaires. Comparative analyses and multiple regression analyses were computed. Results: RM showed lower well-being and fewer social resources than MM and NM. For personal resources, the group differences were less consistent. Personal and social resources predicted the well-being of minors. While multicultural resources were not significant, especially the resources sense of coherence, integration into peer group, and religious identity positively predicted the well-being of RM. Limitations: The group of MM is very heterogeneous. Further studies should differentiate the group of MM more precisely. Conclusion: The differences in well-being among RM, MM and NM can largely be explained by differences in resources. Religious identity is an important available resource for RM. Sense of coherence and integration into peer groups should be given special attention in health promotion for RM.
Geophysical Inversion Using a Variational Autoencoder to Model an Assembled Spatial Prior Uncertainty
Authors: Lopez‐Alvis J. , Nguyen F. , Looms M. C. , Hermans T.
Published: February 2022

Prior information regarding subsurface spatial patterns may be used in geophysical inversion to obtain realistic subsurface models. Field experiments require prior information with sufficiently diverse patterns to accurately estimate the spatial distribution of geophysical properties in the sensed subsurface domain. A variational autoencoder (VAE) provides a way to assemble all patterns deemed possible in a single prior distribution. Such patterns may include those defined by different base training images and also their perturbed versions, for example, those resulting from geologically consistent operations such as erosion/dilation, local deformation, and intrafacies variability. Once the VAE is trained, inversion may be done in the latent space which ensures that inverted models have the patterns defined by the assembled prior. Gradient‐based inversion with both a synthetic and a field case of cross‐borehole GPR traveltime data shows that using the VAE assembled prior performs as good as using the VAE trained on the pattern with the best fit, but it has the advantage of lower computation cost and more realistic prior uncertainty. Moreover, the synthetic case shows an adequate estimation of most small‐scale structures. The absolute values of wave velocity are computed by assuming a linear mixing model which involves two additional parameters that effectively shift and scale velocity values and are included in the inversion.
Single Waveguide Feed Omnidirectional and Circularly Polarized Transceiver Waveguide Slot Antenna for Satellite Communication Applications
Authors: Turkmen C. , Alkin E. , Secmen M.
Published: February 2022

In this study, an omnidirectional and circularly polarized transceiver antenna, which can be used in simultaneous operations over transmit (TX) and receive (RX) channels for telemetry, tracking, and command (TTC) applications on the space segment of satellite communication, is proposed. The radiation and feed parts of the antenna consist of waveguide structures for high power necessity in transmit (telemetry) section. The radiation part includes two different sections of rotationally symmetric slotted arrays on circular waveguide, and radially outward metallic disks to improve omnidirectionality and circular polarization. The feed part contains a dual‐band mod converter from rectangular TE10 mode to circular TM01 mode for symmetric field excitation over slots where the input of the converter is the standard rectangular waveguide. The design, simulation, and measurement results of the antenna are shown over a 3D printed prototype at Ku‐band with center frequencies of 12 GHz and 14.25 GHz for TX and RX, respectively. With thin slots in telemetry section and thick slots in telecommand section, measured bandwidths for TX and RX frequencies are obtained approximately as 200 and 450 MHz, respectively. While TX band with maximum 3 dB gain variation over azimuth, maximum 3 dB axial ratio and minimum −3 dBi gain over 70° elevation beamwidth has relatively better performances at the expense of narrow bandwidth, RX band has maximum 3.5 dB gain variation over azimuth, maximum 4 dB axial ratio and minimum −6 dBi gain over 55° elevation beamwidth at the expense of wide bandwidth.
Effects of Unsaturated Flow on Hydraulic Head Response to Earth Tides–An Analytical Model
Authors: Liang Xiuyu , Wang Chi‐Yuen , Ma Enze , Zhang You‐Kuan
Published: February 2022

Responses of groundwater levels to Earth tides have been widely studied to evaluate aquifer properties because it has been shown to be an economical and effective approach to estimate aquifer parameters. Existing studies suggest that unsaturated zones may have non‐negligible effects on groundwater responses to Earth tides in an unconfined aquifer. However, an analytical model for these effects is unavailable; as a result, the impacts of the unsaturated flow on the tidal response of water levels has not been fully explored. Here we present an analytical solution for the coupled unsaturated‐saturated flow equation, which is linearized by the perturbation method, to study the hydraulic head responses to Earth tides. The solutions are compared with that from numerical simulation using the finite‐element method built in COMSOL Multiphysics and an existing numerical model. The results indicate that the unsaturated zone has significant impacts on the hydraulic head responses to Earth tides. The traditional model for an unconfined aquifer that neglects the effects of an unsaturated zone commonly underestimates the amplitude ratio and overestimates the phase shift. The fluctuations of the water table near the ground surface (<1.0 m) causes dramatic variations of both amplitude ratio and phase shift, which in turn cause the traditional model to fail in estimating aquifer parameters. The solutions are applied to field data to interpret large seasonal variations in the tidal responses. The solutions derived in this study should be an important addition to existing analytical models for tidal analysis.
DNA-methylation dynamics across short-term, exposure-containing CBT in patients with panic disorder
Authors: Moser Sylvain , Martins Jade , Czamara Darina , Lange Jennifer , Müller-Myhsok Bertram , Erhardt Angelika
Published: February 2022

Interaction of genetic predispositions and environmental factors via epigenetic mechanisms have been hypothesized to play a central role in Panic Disorder (PD) aetiology and therapy. Cognitive Behavioral Therapy (CBT), including exposure interventions, belong to the most efficient treatments of PD although its biological mechanism of action remains unknown. For the first time, we explored the dynamics and magnitude of DNA-methylation and immune cell-type composition during CBT (n = 38) and the therapeutic exposure intervention (n = 21) to unravel their biological correlates and identify possible biomarkers of therapy success. We report transient regulation of the CD4 + T-Cells, Natural Killers cells, Granulocytes during exposure and a significant change in the proportions of CD4 + T cells, CD8 + T cells and B-Cells and Granulocytes during therapy. In an epigenome-wide association study we identified cg01586609 located in a CpG island and annotated to the serotonin receptor 3 A (HTR3A) to be differentially methylated during fear exposure and regulated at gene expression level with significant differences between remitters and non-remitters (p = 0.028). We moreover report cg01699630 annotated to ARG1 to undergo long lasting methylation changes during therapy (paired t test, genome-wide adj.pvalue = 0.02). This study reports the first data-driven biological candidates for epigenetically mediated effects of acute fear exposure and CBT in PD patients. Our results provide evidence of changes in the serotonin receptor 3 A methylation and expression during fear exposure associated with different long-term CBT trajectories and outcome, making it a possible candidate in the search of markers for therapy success. Finally, our results add to a growing body of evidence showing immune system changes associated with PD.
Miniaturized thermal acoustic gas sensor based on a CMOS microhotplate and MEMS microphone
Authors: Hopper Richard , Popa Daniel , Udrea Florin , Ali Syed Zeeshan , Stanley-Marbell Phillip
Published: February 2022

We present a miniaturised thermal acoustic gas sensor, fabricated using a CMOS microhotplate and MEMS microphone. The sensing mechanism is based on the detection of changes in the thermal acoustic conversion efficiency which is dependent on the physical properties of the gas. An active sensing element, consisting of a MEMS microphone, is used to detect the target gas while a reference element is used for acoustic noise compensation. Compared to current photoacoustic gas sensors, our sensor requires neither the use of gas-encapsulated microphones, nor that of optical filters. In addition, it has all the benefits of CMOS technology, including production scalability, low cost and miniaturization. Here we demonstrate its application for CO$$_2$$

2

gas detection. The sensor could be used for gas leak detection, for example, in an industrial plant.
Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases
Authors: Lenina Oksana A. , Petrov Konstantin A.
Published: February 2022

Organophosphorus (OP) compounds that inhibit acetylcholinesterase are a common cause of poisoning worldwide, resulting in several hundred thousand deaths each year. The pathways activated during OP compound poisoning via overstimulation of muscarinic acetylcholine receptors (mAChRs) play a decisive role in toxidrome. The antidotal therapy includes atropine, which is a nonspecific blocker of all mAChR subtypes. Atropine is efficient for mitigating depression in respiratory control centers but does not benefit patients with OP-induced skeletal muscle weakness. By using an ex vivo model of OP-induced muscle weakness, we studied the effects of the M1/M4 mAChR antagonist pirenzepine and the M2/M4 mAChR antagonist methoctramine on the force of mouse diaphragm muscle contraction. It was shown that weakness caused by the application of paraoxon can be significantly prevented by methoctramine (1 µM). However, neither pirenzepine (0.1 µM) nor atropine (1 µM) was able to prevent muscle weakness. Moreover, the application of pirenzepine significantly reduced the positive effect of methoctramine. Thus, balanced modulation of neuromuscular synaptic transmission via M1 and M2 mAChRs contributes to paraoxon-induced muscle weakness. It was shown that methoctramine (10 µmol/kg, i.p.) and atropine (50 µmol/kg, i.p.) were equieffective toward increasing the survival of mice poisoned with a 2xLD50dose of paraoxon.
A novel metamaterial-based antenna for on-chip applications for the 72.5–81 GHz frequency range
Authors: Olan-Nuñez Karen N. , Murphy-Arteaga Roberto S.
Published: February 2022

In this paper we present a novel metamaterial-based antenna simulated using HFSS. The unit cell parameters were extracted using periodic boundary conditions and wave-port excitation. The metamaterial is magnetically coupled to the CPW line, the induced current in the hexagonal ring gives rise to a field perpendicular to the incident one. The antenna can be modeled by an LC circuit. This design achieves a significant impedance bandwidth of 8.47 GHz (S11 = − 10 dB from 72.56 GHz to 81.03 GHz), and a minimum return loss of − 40.79 dB at 76.89 GHz, which clearly indicates good impedance matching to 50Ω. The proposed antenna offers gains from 4.53 to 5.25 dBi, with radiation efficiencies better than 74%. Compactness, simple design layout, a novel design, and good radiation characteristics for this antenna are the main contributions of this work. The antenna can be built on top of a 300 µm thick silicon wafer, for application on HR-SOI-CMOS technology. When compared to other antenna designs for the same frequency band, the proposed antenna achieves very good performance. This design is suitable for the reception stage of long-range automobile radar systems, due to its wide HPBW, as well as E-band applications, such as backhaul systems.
Role of the voltage window on the capacity retention of P2-Na2/3[Fe1/2Mn1/2]O2 cathode material for rechargeable sodium-ion batteries
Authors: Zarrabeitia Maider , Nobili Francesco , Lakuntza Oier , Carrasco Javier , Rojo Teófilo , Casas-Cabanas Montse , Muñoz-Márquez Miguel Ángel
Published: February 2022

P2-Na2/3[Fe1/2Mn1/2]O2 layered oxide is a promising high energy density cathode material for sodium-ion batteries. However, one of its drawbacks is the poor long-term stability in the operating voltage window of 1.5–4.25 V vs Na+/Na that prevents its commercialization. In this work, additional light is shed on the origin of capacity fading, which has been analyzed using a combination of experimental techniques and theoretical methods. Electrochemical impedance spectroscopy has been performed on P2-Na2/3[Fe1/2Mn1/2]O2 half-cells operating in two different working voltage windows, one allowing and one preventing the high voltage phase transition occurring in P2-Na2/3[Fe1/2Mn1/2]O2 above 4.0 V vs Na+/Na; so as to unveil the transport properties at different states of charge and correlate them with the existing phases in P2-Na2/3[Fe1/2Mn1/2]O2. Supporting X-ray photoelectron spectroscopy experiments to elucidate the surface properties along with theoretical calculations have concluded that the formed electrode-electrolyte interphase is very thin and stable, mainly composed by inorganic species, and reveal that the structural phase transition at high voltage from P2- to “Z”/OP4-oxygen stacking is associated with a drastic increased in the bulk electronic resistance of P2-Na2/3[Fe1/2Mn1/2]O2 electrodes which is one of the causes of the observed capacity fading.
Ethylene polymerization with a crystallographically well-defined metal–organic framework supported catalyst
Authors: Goetjen Timothy A. , Knapp Julia G. , Syed Zoha H. , Hackler Ryan A. , Zhang Xuan , Delferro Massimiliano , Hupp Joseph T. , Farha Omar K.
Published: February 2022

Crystallographic characterization of a heterogeneous ethylene polymerization catalyst elucidates a chromium–carbon bond after alkyl aluminum activation and provides mechanistic insights.
Hypoglycemic effect of a novel polysaccharide fromLentinus edodeson STZ-induced diabetic miceviametabolomics study and Nrf2/HO-1 pathway
Authors: Gong Pin , Wang Xiaojuan , Liu Meng , Wang Mengrao , Wang Siyuan , Guo Yuxi , Chang Xiangna , Yang Wenjuan , Chen Xuefeng , Chen Fuxin
Published: February 2022

A novel polysaccharide, LNT-1, fromLentinus edodesmay be a potential natural drug candidate for the prevention and treatment of diabetes by regulating the oxidative stress response.
Structure and properties of chitosan/sodium dodecyl sulfate composite films
Authors: Jiang Song , Qiao Congde , Wang Xujie , Li Zhongwei , Yang Guihua
Published: February 2022

SDS binds strongly to chitosan through electrostatic interactions, and it has a remarkable effect on the structure and properties of chitosan films.
Overview of recent lattice QCD results: phase diagram, fluctuations and strangeness
Authors: Guenther Jana N.
Published: February 2022

In recent years there has been much progress on the investigation of the QCD phase diagram with lattice QCD. This work will focus on the developments in the last few years with physical parameters and low chemical potential which are obtained by extrapolations from zero or imaginary chemical potential.
Flavor hierarchy at the chemical freeze-out from UrQMD
Authors: Reichert Tom , Inghirami Gabriele , Bleicher Marcus
Published: February 2022

We introduce a novel approach based on elastic and inelastic scattering rates to extract the hyper-surface of the chemical freeze-out from a hadronic transport simulation. We use the Ultra-relativistic Quantum Molecular Dynamics (UrQMD) model to extract the chemical freeze-out hyper-surface of pions and kaons in the energy range from Elab = 1:23A GeV to √SNN = 7.7 GeV. By employing a coarse-graining procedure, we can extract the local temperature T and baryo-chemical potential μB on the chemical freeze-out surface and compare them to results from statistical model analysis. We find good agreement between the pion chemical freeze-out line extracted from the simulation and the freeze-out line from the statistical model extracted from data. In addition the simulations also hint towards the existence of a flavor hierarchy similar to the one observed in recent lattice QCD calculations.
Elliptic flow for φ mesons measured by PHENIX
Authors: Mitrankov Iurii , Berdnikov Yaroslav , Berdnikov Alexander , Kotov Dmitry
Published: February 2022

The systematic study of hadronic elliptic flow in various relativistic heavy ion collisions is important for the investigation of the initial geometry influence on the quark gluon plasma characteristics. The φ meson consists of strange and antistrange quarks and has a small interaction cross section with non-strange hadrons. Therefore, φ mesons are barely affected by late hadronic stage and reflect detailed information about hot and dense matter properties. Additionally, the comparison of elliptic flow for φ mesons to those of charged hadrons will provide additional information on the flavor dependence of flow. PHENIX has measured second order azimuthal anisotropy coefficients for φ mesons in Cu+Au collisions at √SNN = 200 GeV and in U+U collisions at √SNN = 193 GeV at midrapidity (| η | < 0.35). The obtained data suggest scaling of elliptic flow for φ mesons with eccentricity of participant nucleons in Cu+Au, U+U, and Au+Au collisions. Viscous hydrodynamic model iEBE-VISHNU provides a simultaneous description of the obtained data.
Thermal-model-based characterization of heavy-ion-collision systems at chemical freeze-out
Authors: Karthein Jamie M. , Alba Paolo , Mantovani-Sarti Valentina , Noronha-Hostler Jacquelyn , Parotto Paolo , Portillo-Vazquez Israel , Vovchenko Volodymyr , Koch Volker , Ratti Claudia
Published: February 2022

We investigate the chemical freeze-out in heavy-ion collisions (HICs) and the impact of the hadronic spectrum on thermal model analyses [1, 2]. Detailed knowledge of the hadronic spectrum is still an open question, which has phenomenological consequences on the study of HICs. By varying the number of resonances included in Hadron Resonance Gas (HRG) Model calculations, we can shed light on which particles may be produced. Furthermore, we study the influence of the number of states on the so-called two flavor freezeout scenario, in which strange and light particles can freeze-out separately. We consider results for the chemical freeze-out parameters obtained from thermal model fits and from calculating net-particle fluctuations. We will show the effect of using one global temperature to fit all particles and alternatively, allowing particles with and without strange quarks to freeze-out separately.
Shear-induced spin polarization and “strange memory” in heavy-ion collisions
Authors: Liu Shuai Y. F. , Fu Baochi , Pang Longgang
Published: February 2022

We discuss the theory of the spin polarizations induced by hydrodynamic gradients, which includes a newly discovered shear-induced polarization (SIP) term. In the phenomenological study using a hydrodynamic model, we discover that the local polarization contributed by SIP is substantial and has the “same sign” as the experimental measurements. Also, we find that the “sign” property of the local polarization observed in experiments seems to be related to “memory” effects on the polarizations of strange quarks in quark-gluon plasma.
Prise en charge de l’algoneurodystrophie ou Syndrome Douloureux Régional Complexe chez l’enfant et l’adolescent : la nécessité d’une approche en équipes
Authors: Greco Céline , Mulliez Adèle , Fertout-Aharouni Élise
Published: February 2022

Dans le cadre de consultations spécifiques pour des patients souffrant de « douleurs chroniques », nous sommes régulièrement amenés à rencontrer des enfants (en général dès l’âge de 7 ans) et des adolescents, adressés le plus souvent par des chirurgiens orthopédistes pédiatriques pour la prise en charge d’algoneurodystrophies (ou Syndrome Douloureux Régional Complexe de type 1) rebelles aux traitements antalgiques classiques. Nous décrivons notre expérience auprès de ces patients avec la nécessité de porter autant d’attention à la véracité de leur vécu douloureux qu’à leur histoire de vie, leur personnalité et les relations avec leur entourage.

La réussite de la rencontre avec ces patients, leur acceptation de notre aide reposent sur la qualité de notre écoute et la pluridisciplinarité de la prise en charge : celui du médecin et du psychologue en consultation, celui des autres professionnels et des équipes relais.
La Covid-19 en Guadeloupe : souffrances et résistances
Authors: Eynaud Michel , Racon Patrick
Published: February 2022

L’épidémie de Covid-19 a connu une intensité particulière en Guadeloupe, avec des taux très importants d’incidence et de mortalité. Sa survenue dans une population présentant de nombreux facteurs de risque, une situation socioéconomique précaire, et un système hospitalier fragile, relève d’une situation de syndémie.

L’épidémie virale s’est doublée d’une épidémie psychique avec une forte augmentation du recours aux services de la psychiatrie publique se traduisant par l’accroissement du nombre de nouveaux patients, des actes de soins ambulatoires, du recours à l’hospitalisation, tant en psychiatrie générale qu’infantojuvénile. La défense contre l’angoisse générée par l’épidémie, les mesures de restrictions de déplacements et de relations sociales, a pris de multiples formes et relève de facteurs et mécanismes pluriels, chez les adultes, les mineurs ou les professionnels de santé.

Une forte résistance à la vaccination s’est manifestée, illustrant les limites de la démocratie sanitaire. L’opposition au vaccin s’est reliée notamment au scandale écologique et sanitaire de l’usage du Chlordécone, l’opposition à un produit chimique devenant opposition à l’état, mais aussi à toute forme d’autorité. Cette politisation de la santé est aussi portée par un syndicat à visée indépendantiste. La défiance à l’égard de ce qui vient de l’extérieur, ainsi que les enjeux identitaires et culturels ont participé aussi au retard à la vaccination, le repli sur la pharmacopée traditionnelle associant une identité faite de résistance et une appartenance protectrice. Le repli sur des identités de confrontation entre « pro » et « anti » remet en question l’identité relationnelle qui est celle de la créolisation.
Persönliche Entfaltung ist alles – Generation Y als Angestellte
Authors: Indermühle Yvonne
Published: February 2022

Wer zwischen 1981 und 1995 geboren wurde, gehört zur Generation Y. Diese gilt beruflich als sehr wählerisch. Daher gibt es für Arbeitgebende einiges zu beachten, wenn sie Arbeitnehmerinnen und Arbeitnehmern der Generation Y eine attraktive Stelle bieten möchten.
Noch einiges auf der Agenda – Berufspolitik
Authors: Mischner Julia Marlene
Published: February 2022

Dass in den letzten Jahren berufspolitisch nichts los war, kann man nicht gerade sagen. Die beiden ergotherapeutischen Berufsverbände Deutschlands ziehen Bilanz zu den berufspolitischen Vorgängen der letzten Zeit und geben einen Ausblick auf anstehende Themen.
Indium-Mediated Reformatsky Reaction of Iododifluoro Ketones with Aldehydes: Preparation of α,α-Difluoro-β-hydroxyketone Derivatives in Water
Authors: Huang Jinwen , Wu Fanhong , Li Zhongyuan , Ni Zhuang , Sun Ran , Nie Hui , Tang Hui , Song Lixing
Published: February 2022

Indium can efficiently mediate the Reformatsky reaction of iododifluoroacetylketones with aldehydes to afford the corresponding α,α-difluoro-β-hydroxyketones in high yield in pure water This reaction has excellent substrate suitability and functional group selectivity and provides an efficient approach for the synthesis of bioactive molecules containing the α,α-difluoro-β-hydroxyketone pharmacophore.
Thoracolumbar Instrumentation Surgery in Patients with Parkinson's Disease: A Case-Control Study
Authors: Spindler Philipp , Tkatschenko Dimitri , Alzoobi Yasmin , Kuebler Dorothee , Kühn Andrea A. , Schneider Gerd-Helge , Prinz Vincent , Vajkoczy Peter , Faust Katharina
Published: February 2022

Background With increasing prevalence of Parkinson's disease (PD), instrumentation surgery of the thoracolumbar spine of PD patients grows in importance. Poor operative results with high rates of revision surgery have been reported. The goal of this study was to compare the biomechanical complications of thoracolumbar instrumentation surgery of patients with and without PD.

Methods In a retrospective case-control study, we compared 16 PD patients with a matched cohort of 104 control patients regarding the following postinstrumentation complications: (1) adjacent joint disease, (2) material failure, and (3) material loosening. Also, we compared the spinal bone density, which is the main prognostic criteria for failed instrumentation surgery, between the groups.

Results We found the rate of material revision to be significantly higher in PD patients (43.8 vs. 13.5%, p = 0.008, odds ratio (OR) = 5.0). Furthermore, the indications for revision surgery differed between the groups, with more hardware failures in the PD group and more adjacent segment degeneration in the control group. PD patients profited from modern operation techniques (percutaneous instrumentation and CT-navigated screw implantation). Hospitalization was significantly longer for PD patients (20.2 ± 15.1 vs. 14.1 ± 8.9 days, p = 0.03).

Conclusion PD patients exhibit challenging biomechanical demands on instrumenting the spine. Besides osteoporosis, especially sagittal imbalance, gait disturbance, and altered muscle tone may be contributive. PD patients may particularly profit from navigated and less invasive surgical techniques.
Comparison of collisionless plasma models identifies a robust candidate for nonlinear phenomena
Authors: Johnson-Groh Mara
Published: February 2022

Testing two kinetic collisionless plasma models found one good for low-frequency phenomena and another suited to nonlinear cases.
Machine learning symbolic equations for diffusion with physics-based descriptions
Authors: Papastamatiou Konstantinos , Sofos Filippos , Karakasidis Theodoros E.
Published: February 2022

This work incorporates symbolic regression to propose simple and accurate expressions that fit to material datasets. The incorporation of symbolic regression in physical sciences opens the way to replace “black-box” machine learning techniques with representations that carry the physical meaning and can reveal the underlying mechanism in a purely data-driven approach. The application here is the extraction of analytical equations for the self-diffusion coefficient of the Lennard-Jones fluid by exploiting widely incorporating data from the literature. We propose symbolic formulas of low complexity and error that achieve better or comparable results to well-known microscopic and empirical expressions. Results refer to the material state space both as a whole and in distinct gas, liquid, and supercritical regions.
Potassium management effects on yield and quality of cassava varieties in tropical sandy soils
Authors: Gazola Bruno , Fernandes Adalton M. , Hellmeister Gabriela , Abrami Laura S. , Silva Rudieli M. , Soratto Rogério P.
Published: February 2022

Potassium (K) fertilisation at planting time may not be sufficient to achieve high cassava yields. Experiments were conducted over two growing periods using sweet cassava (SC) variety IAC 576-70 and bitter cassava (BC) variety IAC 13 aiming to evaluate the effects of K fertilisation rate (0–150 kg K/ha) and timing of application (one, two, or three) on leaf K concentration, yield components, and storage-root and starch yields. The SC and BC varieties were grown in a randomized block design in a 3 × 4 + 1 factorial scheme with four replications during growing periods of 10 and 20 months respectively. For SC, split application of K at planting plus 3 months after planting (MP) or at planting plus 1.5 and 3 MP was more effective at increasing the marketable root yield, with greater rainfall at the beginning of the growing period. Split application of K at planting plus 3 MP also reduced the cooking time and cooked root firmness. For BC, split application of K at planting plus 12 MP more effectively increased the storage-root and starch yields; however, root yield response to K fertilisation in the second growing period, with greater rain intensity during the initial crop stages, was greater than in the first growing period. In K-deficient soils, the optimal K application rate for SC marketable root yield varied from 79 to 111 kg/ha when K was applied after 1.5 MP, and linear responses to K application rate occurred when K was applied earlier. For BC, the optimal K application rate varied from 75 to 92 kg K/ha. Our data suggest that K application times should be different for cassava varieties with short and long growing periods.
UbE3-APA: a bioinformatic strategy to elucidate ubiquitin E3 ligase activities in quantitative proteomics study
Authors: Gong Yao , Chen Yue
Published: February 2022

Motivation

Ubiquitination is widely involved in protein homeostasis and cell signaling. Ubiquitin E3 ligases are critical regulators of ubiquitination that recognize and recruit specific ubiquitination targets for the final rate-limiting step of ubiquitin transfer reactions. Understanding the ubiquitin E3 ligase activities will provide knowledge in the upstream regulator of the ubiquitination pathway and reveal potential mechanisms in biological processes and disease progression. Recent advances in mass spectrometry-based proteomics have enabled deep profiling of ubiquitylome in a quantitative manner. Yet, functional analysis of ubiquitylome dynamics and pathway activity remains challenging.

Results

Here, we developed a UbE3-APA, a computational algorithm and stand-alone python-based software for Ub E3 ligase Activity Profiling Analysis. Combining an integrated annotation database with statistical analysis, UbE3-APA identifies significantly activated or suppressed E3 ligases based on quantitative ubiquitylome proteomics datasets. Benchmarking the software with published quantitative ubiquitylome analysis confirms the genetic manipulation of SPOP enzyme activity through overexpression and mutation. Application of the algorithm in the re-analysis of a large cohort of ubiquitination proteomics study revealed the activation of PARKIN and the co-activation of other E3 ligases in mitochondria depolarization-induced mitophagy process. We further demonstrated the application of the algorithm in the DIA (data-independent acquisition)-based quantitative ubiquitylome analysis.

Availability and implementation

Source code and binaries are freely available for download at URL: https://github.com/Chenlab-UMN/Ub-E3-ligase-Activity-Profiling-Analysis, implemented in python and supported on Linux and MS Windows.

Supplementary information

Supplementary data are available at Bioinformatics online.
Equity in a sea of debt: how better understanding of small-scale fisheries can help reel in sustainable seafood
Authors: Phelan Anna (Anya) , Ross Helen , Adhuri Dedi S , Richards Russell
Published: February 2022

Small-scale fisheries are globally important to food security, nutrition, culture, ecosystem health, and livelihoods for millions of people. They also face considerable ecological, and economic pressures, including climate change, privatization, and top-down decision-making. Historically, processes of exclusion (e.g. industrialization, market forces, and settler colonialism) have persisted in the global food system. To mitigate against such processes and protect the livelihoods and human rights of small-scale fishers, the socially responsible seafood movement has emerged. This paper examines the local relationships in a seafood value chain in Indonesia, which extends from village fishers to international export markets. We present a case study from Sumbawa Indonesia, where a foreign direct seafood exporter is focused on sourcing socially responsible seafood from waters worked by small-scale fishers. Applying a systems lens, we analyse how a system driven by market forces and underpinned by western values can integrate with a system driven by traditional customs, social ties, and trust. The findings demonstrate that social connections and feedbacks within the value chain play a key role. Systems thinking reveals pathways to help synergize the two systems. This research shows that to deliver on the promise of socially responsible seafood, better understanding is needed of the interconnected social, cultural, and economic ties of small-scale fishers.
Comparison of Commercial Test Kits for Detection of Salmonella and E. coli O157:H7 in Alfalfa Spent Sprout Irrigation Water
Authors: Fu Tong-Jen , Maks Nicole , Shazer Arlette G , Chrysogelos Christina
Published: February 2022

Background

Sprout growers in the United States are required to test spent sprout irrigation water (SSIW) or in-process sprouts for Escherichia coli O157:H7 and Salmonella species. Pathogen screening kits are commercially available; however, few have been validated for analysis of sprouts or SSIW.

Objective

This study evaluated AOAC-certified test kits (lateral flow devices [LFDs], enzyme immunoassays [EIAs], and molecular assays) in comparison with culture methods described in the U.S. Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) for detection of Salmonella and E. coli O157:H7 in alfalfa SSIW.

Method

Twenty-five milliliter aliquots of alfalfa SSIW, either uninoculated or inoculated with Salmonella or E. coli O157:H7 at a low (∼0.5–0.7 CFU/25 mL) or high level (∼10–20 CFU/25 mL), were subjected to the enrichment and assay protocols recommended by each test. Pathogen presence was confirmed following FDA BAM procedures and, if applicable, test kit manufacturer protocols.

Results

Twelve of the 13 Salmonella test kits evaluated (except VIDAS UP) performed well and detected Salmonella in 100% of SSIW samples contaminated at 0.61 CFU/mL. Performance varied among E. coli O157:H7 test kits, with four (Reveal, MicroSEQ, GDS, MDA) of 12 kits designed for next-day detection, and four (Reveal, VIP Gold, MicroSEQ, GDS) of seven kits designed for same-day detection capable of detecting the pathogen in 100% samples contaminated at 0.90 CFU/mL.

Conclusions

Enrichment conditions play a key role in determining the performance of test kits and the success of confirmation.

Highlights

This study is the first to compare a wide range of commercial test kits for detection of Salmonella and E. coli O157:H7 in SSIW.
The Clinical and Economic Impact of Measles-Mumps-Rubella Vaccinations to Prevent Measles Importations From US Pediatric Travelers Returning From Abroad
Authors: Bangs Audrey C , Gastañaduy Paul , Neilan Anne M , Fiebelkorn Amy Parker , Walker Allison Taylor , Rao Sowmya R , Ryan Edward T , LaRocque Regina C , Walensky Rochelle P , Hyle Emily P
Published: February 2022

Background

Pediatric international travelers account for nearly half of measles importations in the United States. Over one third of pediatric international travelers depart the United States without the recommended measles-mumps-rubella (MMR) vaccinations: 2 doses for travelers ≥12 months and 1 dose for travelers 6 to <12 months.

Methods

We developed a model to compare 2 strategies among a simulated cohort of international travelers (6 months to <6 years): (1) No pretravel health encounter (PHE): travelers depart with baseline MMR vaccination status; (2) PHE: MMR-eligible travelers are offered vaccination. All pediatric travelers experience a destination-specific risk of measles exposure (mean, 30 exposures/million travelers). If exposed to measles, travelers’ age and MMR vaccination status determine the risk of infection (range, 3%-90%). We included costs of medical care, contact tracing, and lost wages from the societal perspective. We varied inputs in sensitivity analyses. Model outcomes included projected measles cases, costs, and incremental cost-effectiveness ratios ($/quality-adjusted life year [QALY], cost-effectiveness threshold ≤$100 000/QALY).

Results

Compared with no PHE, PHE would avert 57 measles cases at $9.2 million/QALY among infant travelers and 7 measles cases at $15.0 million/QALY among preschool-aged travelers. Clinical benefits of PHE would be greatest for infants but cost-effective only for travelers to destinations with higher risk for measles exposure (ie, ≥160 exposures/million travelers) or if more US-acquired cases resulted from an infected traveler, such as in communities with limited MMR coverage.

Conclusions

Pretravel MMR vaccination provides the greatest clinical benefit for infant travelers and can be cost-effective before travel to destinations with high risk for measles exposure or from communities with low MMR vaccination coverage.
We Are All Police—Abu Dhabi Police Community Engagement Initiative
Authors: Al Manhali Al Haye , Al Kaabi Faisal , Al Hanaee Mohamed
Published: February 2022

Globally, the concept of community policing while applied in a myriad of customized strategies to meet the needs of individual environments is underpinned by common objectives, which include engaging the community to complement a core business of policing, community safety. In parallel, police agencies of all sizes and nationalities have developed a range of targeted campaigns to support and enhance community engagement with police to contribute to building safe communities. The combination of ‘soft power’ or ‘soft’ policing strategies with community policing campaigns is a central tenant of the Abu Dhabi Police, We Are All Police initiative. This article presents the journey of the We Are All Police initiative and the outcome for more than 200 nationalities combining in a 1.48 million population of Abu Dhabi residents. Aligning the vision, aims, purpose, acceptance, and impact of the Abu Dhabi Police community-based strategy contributes to informing deliberations of policy and practice in the policing of a modern society.