bluuebunny/crossref_metadata_2025 huggingface dataset:
Construction of the Ohio Children's Opportunity Index
Authors: Fareed Naleef , Singh Priti , Jonnalagadda Pallavi , Swoboda Christine , Odden Colin , Doogan Nathan
Published: July 2022

Objective

To describe the development of an area-level measure of children's opportunity, the Ohio Children's Opportunity Index (OCOI).

Data Sources/Study Setting

Secondary data were collected from US census based-American Community Survey (ACS), US Environmental Protection Agency, US Housing and Urban Development, Ohio Vital Statistics, US Department of Agriculture-Economic Research Service, Ohio State University Center for Urban and Regional Analysis, Ohio Incident Based Reporting System, IPUMS National Historical Geographic Information System, and Ohio Department of Medicaid. Data were aggregated to census tracts across two time periods.

Study Design

OCOI domains were selected based on existing literature, which included family stability, infant health, children's health, access, education, housing, environment, and criminal justice domains. The composite index was developed using an equal weighting approach. Validation analyses were conducted between OCOI and health and race-related outcomes, and a national index.

Principal Findings

Composite OCOI scores ranged from 0–100 with an average value of 74.82 (SD, 17.00). Census tracts in the major metropolitan cities across Ohio represented 76% of the total census tracts in the least advantaged OCOI septile. OCOI served as a significant predictor of health and race-related outcomes. Specifically, the average life expectancy at birth of children born in the most advantaged septile was approximately 9 years more than those born in least advantaged septile. Increases in OCOI were associated with decreases in proportion of Black (48 points lower in the most advantaged vs. least advantaged septile), p < 0.001) and Minority populations (54 points lower in most advantaged vs. least advantaged septile, p < 0.001). We found R-squared values > 0.50 between the OCOI and the national Child Opportunity Index scores. Temporally, OCOI decreased by 1% between the two study periods, explained mainly by decreases in the children health, accessibility and environmental domains.

Conclusion

As the first opportunity index developed for children in Ohio, the OCOI is a valuable resource for policy reform, especially related to health disparities and health equity. Health care providers will be able to use it to obtain holistic views on their patients and implement interventions that can tackle barriers to childhood development using a more tailored approach.
Corticosteroids showed more efficacy in treating hospitalized patients with COVID-19 than standard care but the effect is minimal: A systematic review and meta-analysis
Authors: Liu Jixin , Dong Jing , Yu Yage , Yang Xinna , Shu Juan , Bao Hairong
Published: July 2022

Background

During the ongoing coronavirus disease 2019 (COVID-19) pandemic, the use of corticosteroids for COVID-19 has ignited worldwide debate. Previous systematic reviews, including randomized controlled trials (RCTs) and retrospective observational studies, found that corticosteroids have beneficial effects in treating COVID-19.

Aim

This systematic review and meta-analysis only included RCTs to assess the effectiveness and safety of corticosteroids in hospitalized patients with COVID-19.

Methods

Comprehensive research strategies (PubMed, Embase, MEDLINE, and Coherence Library) were used to search for RCTs from December 2019 to January 2021.

Results

Five RCTs were included with 7,235 patients, of which 2,508 patients were receiving corticosteroid treatments (dexamethasone or methylprednisolone), and 4,727 received standard care. The primary outcome was mortality within 28 days. The use of corticosteroids decreased the 28-day mortality of patients with COVID-19, but the findings were not statistically significant (RR, 0.91; 95% CI, 0.78–1.06, p = 0.24). The secondary outcome was the duration of hospitalization; no differences were found between the corticosteroid and standard care groups. However, corticosteroids were associated with a higher hospital discharge rate than standard treatment, but the result was not statistically significant (RR, 1.36; 95% CI, 0.95–1.96, p = 0.09).

Conclusions

The results suggest that corticosteroids are comparable to standard care in terms of safety in treating COVID-19. Corticosteroids showed greater efficacy than standard care; however, the effect was minimal.
When Lack of Trust in the Government and in Scientists Reinforces Social Inequalities in Vaccination Against COVID-19
Authors: Bajos Nathalie , Spire Alexis , Silberzan Léna , Sireyjol Antoine , Jusot Florence , Meyer Laurence , Franck Jeanna-Eve , Warszawski Josiane ,   The EpiCov study group
Published: July 2022

Objective

To assess whether lack of trust in the government and scientists reinforces social and racial inequalities in vaccination practices.

Design

A follow-up of the EpiCov random population-based cohort survey.

Setting

In July 2021, in France.

Participants

Eighty-thousand nine hundred and seventy-one participants aged 18 years and more.

Main Outcome Measures

Adjusted odds ratios of COVID-19 vaccination status (received at least one dose/ intends to get vaccinated/ does not know whether to get vaccinated/refuses vaccination) were assessed using multinomial regressions to test associations with social and trust factors and to study how these two factors interacted with each other.

Results

In all, 72.2% were vaccinated at the time of the survey. The population of unvaccinated people was younger, less educated, had lower incomes, and more often belonged to racially minoritized groups, as compared to vaccinated people. Lack of trust in the government and scientists to curb the spread of the epidemic were the factors most associated with refusing to be vaccinated: OR = 8.86 (7.13 to 11.00) for the government and OR = 9.07 (7.71 to 10.07) for scientists, compared to vaccinated people. Lack of trust was more prevalent among the poorest which consequently reinforced social inequalities in vaccination. The poorest 10% who did not trust the government reached an OR of 16.2 (11.9 to 22.0) for refusing to be vaccinated compared to the richest 10% who did.

Conclusion

There is a need to develop depoliticised outreach programmes targeted at the most socially disadvantaged groups, and to design vaccination strategies conceived with people from different social and racial backgrounds to enable them to make fully informed choices.
The diagnostic utility of IL-10, IL-17, and PCT in patients with sepsis infection
Authors: Zhang Wei , Wang Weiwei , Hou Weiwei , Jiang Chenfei , Hu Jingwen , Sun Li , Hu Liqing , Wu Jian , Shang Anquan
Published: July 2022

Objective

The purpose of this study is to determine the diagnostic value and net clinical benefit of interleukin-10 (IL-10), interleukin-17 (IL-17), procalcitonin (PCT), and combination tests in patients with sepsis, which will serve as a standard for sepsis early detection.

Patients and methods

An investigation of 84 sepsis patients and 81 patients with local inflammatory diseases admitted to the ICU of Tongji University Hospital in 2021. In addition to comparing inter-group variability, indicators relevant to sepsis diagnosis and therapy were screened.

Results

LASSO regression was used to examine PCT, WBC, CRP, IL-10, IFN-, IL-12, and IL-17. Multivariate logistic regression linked IL-10, IL-17, and PCT to sepsis risk. The AUC values of IL-10, IL-17, PCT, and the combination of the three tests were much higher than those of standard laboratory infection indicators. The combined AUC was greater than the sum of IL-10, IL-17, and PCT (P < 0.05). A clinical decision curve analysis of IL-10, IL-17, PCT, and the three combined tests found that the three combined tests outperformed the individual tests in terms of total clinical benefit rate. To predict the risk of sepsis using IL-10, IL-17, and PCT had an AUC of 0.951, and the model's predicted probability was well matched. An examination of the nomogram model's clinical value demonstrated a considerable net therapeutic benefit between 3 and 87%.

Conclusion

The IL-10, IL-17, and PCT tests all have a high diagnostic value for patients with sepsis, and the combination of the three tests outperforms the individual tests in terms of diagnostic performance, while the combined tests have a higher overall clinical benefit rate.
An update on the impact of SARS-CoV-2 pandemic public awareness on cancer patients' COVID-19 vaccine compliance: Outcomes and recommendations
Authors: Souan Lina , Sughayer Maher A. , Abu Alhowr Maha , Ammar Khawlah , Bader Sara Al
Published: July 2022

Background:

Aside from the pandemic's negative health effects, the world was confronted with public confusion since proper communication and favorable decisions became an ongoing challenge. As a result, the public's perceptions were influenced by what they knew, the many sources of COVID-19 information, and how they interpreted it. With cancer patients continuing to oppose COVID-19 vaccines, we sought to investigate the COVID-19 pandemic and vaccine sources of this information in adult cancer patients, which either helped or prevented them from taking the vaccine. We also assessed the relevance and impact of their oncologists' recommendations in encouraging them to take the vaccine.

Methods

From June to October 2021, an online survey was conducted at King Hussein Cancer Center. A total of 441 adult cancer patients took part in the study. Patients who had granted their consent were requested to complete an online questionnaire, which was collected using the SurveyMonkey questionnaire online platform. Descriptive analysis was done for all variables. The association between categorical and continuous variables was assessed using the Pearson Chi-square and Fisher Exact.

Results

Our results showed that 75% of the patients registered for the COVID-19 vaccine, while 12% refused vaccination. The majority of participants acquired their information from news and television shows, whereas (138/441) got their information through World Health Organization websites. Because the SARS-CoV-2 vaccines were made in such a short period, 54.7 % assumed the vaccines were unsafe. Only 49% of the patients said their oncologists had informed them about the benefits of SARS-CoV-2 vaccines.

Conclusions

We found that SARS-CoV-2 vaccine hesitancy in cancer patients might be related to misinformation obtained from social media despite the availability of supportive scientific information on the vaccine's benefits from the physicians. To combat misleading and unreliable social media news, we recommend that physicians use telehealth technology to reach out to their patients in addition to their face-to-face consultation, which delivers comprehensive, clear, and high-quality digital services that guide and help patients to better understand the advantages of COVID-19 vaccines.
Economic Aspects in the Management of Diabetic Macular Edema in Italy
Authors: Calabrò Giovanna Elisa , Basile Michele , Varano Monica , Amore Filippo , Ricciardi Roberto , Bandello Francesco , Cicchetti Americo
Published: July 2022

Background

Diabetic Macular Edema (DME) is the most common cause of vision loss in diabetic patients. Currently, the Vascular Endothelial Growth Factor inhibitors (anti-VEGFs) are used as the first line of DME treatment and corticosteroid implants are usually used as a second-line treatment. These implants are a safe and effective therapeutic option that can improve the quality of life of DME patients by reducing the intravitreal injections number. We determined the economic impact related to DME, also from the social perspective, and the consequences of the increased use of the dexamethasone implant.

Methods

The analysis compares two scenarios: the first based on the current rate of recourse to the therapeutic alternatives available in the Italian healthcare setting (as is) and the second based on the assumption of an increased recourse to dexamethasone implants (to be). The results are expressed both in terms of the resource absorption associated with the two scenarios and in terms of the cost differential yielded by their comparison.

Results

The increased use of the dexamethasone implant allows considerable savings in terms of healthcare professionals' time, follow-up and productivity lost by patients/caregivers. These savings would reduce healthcare costs for the management of DME patients in Italy by €2,058,238 in 5 years.

Conclusions

To optimize the healthcare resources allocation, it is necessary to implement treatments that yield not only cost reductions but also a clinical benefit for patients. The dexamethasone implant use is an example of DME management that generates value for patients, health system and society.
Information disclosure, practical actions and dynamics of employees' health and safety issues in Chinese family businesses—Evidence based on Chinese a-share listed companies
Authors: Guo Yi , Li Aijun , Zhou Yi , Di Yuna
Published: July 2022

Introduction

Global health emergency as COVID-19 has brought unprecedented concerns to the health and safety of employees, which is important yet long-neglected. This paper studies the mechanism and influencing factors of Chinese family enterprises performance in employees' health and safety from information disclosure, practical action and dynamic change. And based on theoretical framework and empirical model, this paper provides feasible regulatory policies on the behavior of family business.

Methods

This study construct a game theory framework and uses a sample of Chinese A-share listed companies. The database is provided by a third-party corporate social responsibility rating agency, SynTao Green Finance. We use empirical models to test the hypothesis from the theoretical model of game theory.

Results

In practice, family businesses are less likely to fulfill the health and safety responsibilities of employees compared to non-family businesses. Family businesses are likely to be more motivated than other businesses to send signals that they are performing their responsibilities well. From the view of operation term, family businesses will be gradually inclined to better fulfill the health and safety responsibilities of their employees, while this process will show a “U” shape change over operation time.

Conclusions

As there is inconsistency between the information disclosure and actual practice of family enterprises when it comes to the issue of employee health and safety, more related regulatory policies and stakeholder monitoring are needed. Although the performance of family enterprises in this regard will be better in the long run, it is still necessary to improve employees' legal and rights awareness and enhance the effectiveness of supervision over external stakeholders.
Epidemiology of children's swimming competence and water safety
Authors: Santibañez-Gutierrez Asier , Fernández-Landa Julen , Calleja-González Julio , Todorović Nikola , Ranisavljev Marijana , Štajer Valdemar , Anđelić Bogdan , Zenić Nataša , Bianco Antonino , Drid Patrik
Published: July 2022

Introduction

The main purpose of this study was to investigate children's swimming competence in primary schools of districts in Vojvodina, Serbia.

Methods

Included subjects were primary school students from first to eighth grade (N = 2,778; male = 1,454, female = 1,324; age = 10.73 ± 2.1 years). We used Swimming Competence Questionnaire to acquire and analyze their swimming experience, non-fatal aquatic events, and demographics. For the statistical analysis, logistic regression and hierarchical multiple regression were used to evaluate if the factors and SC and NFAE were associated. The analyses were carried out by using SPSS® software version 24.0 (SPSS, Inc., Chicago, Illinois, USA).

Results

Families with more income and education generally have children with more swimming competence, experience, knowledge, and skills related to water safety. First step in analysis revealed that gender (β = 0.05, p < 0.01), education level (β = 0.06, p < 0.01) age (β = 0.171, p < 0.01), and family income (β = 0.04, p < 0.01) were significant swimming competence (SC) predictors (R2 = 0.04). Age (OR = 1.15, p < 0.01) was the only significant predictor in Step 1 predicting non-fatal aquatic events (NFAE). In Step 2, variables associated with SC were swimming location (ΔR2 = 0.06, p < 0.01), swimming experience (ΔR2 = 0.16, p < 0.01), swimming accessibility (ΔR2 = 0.05, p < 0.01), and learning experience (ΔR2 = 0.03, p < 0.01) (total R2 = 0.26 to 0.47, p < 0.01). Only a minority of participants reported that they could not swim further than 5 meters using general stroke (37.15%).

Conclusion

National education trainers programs must be prioritized with the primary strategy of transferring knowledge to swimming and water safety. Families with lower income must be included without exceptions. This is perhaps a key factor in preventing NFAE, increasing SC, and increasing water safety.
Machine translation and foreign language education
Authors: Urlaub Per , Dessein Eva
Published: July 2022

Online machine translation tools have great potential to transform foreign language education. This essay will synthesize systematic research on the role of machine translation conducted in the field of educational linguistics. After describing approaches developed that promote the integration of machine translation into language learning environments, the essay will briefly outline lingering concerns associated with the integration of MT tools into educational settings. We will propose future R&D priorities that can generate products based on existing technologies that have the potential to support language learners more optimally compared to existing machine translation tools. We conclude that an acknowledgment of the difficulties of MT tools to handle socio-culturally complex source text would pave the way for the development of MT-based pedagogical tools.
Using the DiCoT framework for integrated multimodal analysis in mixed-reality training environments
Authors: Vatral Caleb , Biswas Gautam , Cohn Clayton , Davalos Eduardo , Mohammed Naveeduddin
Published: July 2022

Simulation-based training (SBT) programs are commonly employed by organizations to train individuals and teams for effective workplace cognitive and psychomotor skills in a broad range of applications. Distributed cognition has become a popular cognitive framework for the design and evaluation of these SBT environments, with structured methodologies such asDistributed Cognition for Teamwork (DiCoT)used for analysis. However, the analysis and evaluations generated by such distributed cognition frameworks require extensive domain-knowledge and manual coding and interpretation, and the analysis is primarily qualitative. In this work, we propose and develop the application of multimodal learning analysis techniques to SBT scenarios. Using these analysis methods, we can use the rich multimodal data collected in SBT environments to generate more automated interpretations of trainee performance that supplement and extend traditional DiCoT analysis. To demonstrate the use of these methods, we present a case study of nurses training in a mixed-reality manikin-based (MRMB) training environment. We show how the combined analysis of the video, speech, and eye-tracking data collected as the nurses train in the MRMB environment supports and enhances traditional qualitative DiCoT analysis. By applying such quantitative data-driven analysis methods, we can better analyze trainee activities online in SBT and MRMB environments. With continued development, these analysis methods could be used to provide targeted feedback to learners, a detailed review of training performance to the instructors, and data-driven evidence for improving the environment to simulation designers.
Peer Counseling: Method, Metaphor, or Mindset?
Authors: Jordan Leonora Micah
Published: July 2022

Peer Counseling and Peer-to-Peer-Counseling are two common counseling formats worldwide where people meet each other at eye level. Rooted in the Independent Living and Self-Help Movement, “classic” Peer Counseling can be considered a professional counseling service offered by and for people with disabilities. In this article, the question is explored whether Peer Counseling is far more reaching than just being labeled as a counseling method. In many countries, it has now found a permanent place in the counseling landscape among others. Furthermore, the question arises whether it does not also serve as a metaphor for a self-determined way of life. In addition, in this study it will be determined whether and why the mindset and attitude are also important in professional Peer Counseling. Since 2018, Peer Counseling has been offered at over 500 counseling centers in Germany as part of the “Ergänzende unabhängige Teilhabeberatung—EUTB®” (Additional Independent Participation Consulting). At a low-threshold and accessible level, advice seekers can find competent individual-centered professional counseling here—often from experts by experience: peers. For many people seeking advice, this is the first and last point of contact for all matters relating to rehabilitation, inclusion and social participation. As part of my PhD-project, I am doing research on Peer Counseling and parallel to this, I train EUTB- and Peer Counselors. Peer Counseling actually is (much more than) a counseling approach which represents a true enrichment for everyone.
A protocol to evaluate the impact of embedding Public and Patient Involvement in a structured PhD program for stroke care
Authors: Horgan Frances , Lennon Olive , Hickey Anne , Sorensen Jan , Kroll Thilo , McCartan Deirdre , Hall Patricia , O'Callaghan Geraldine , Fitzgerald Clare , Hickey Julianne , Fahy Martin , Osborne Philip , Scullion Mary , Ní Bhroin Clíodhna , Williams David J. ,   The iPASTAR Collaborative Doctoral Award Programme Team
Published: July 2022

Background

Embedding Public and Patient Involvement (PPI) in postgraduate research has been recognized as an important component of post-graduate training, providing research scholars with an awareness and a skillset in an area which prepares them for future roles as healthcare researchers. Improving Pathways for Acute STroke And Rehabilitation (iPASTAR) is a structured PhD training program [Collaborative Doctoral Award (CDA)] which aims to design a person-centered stroke pathway throughout the trajectory of stroke care, to optimize post-stroke health and wellbeing. PPI is embedded at all stages.

Purpose

The iPASTAR research programme was strongly informed by a round-table PPI consultation process with individuals who experienced stroke and who provided broad representation across ages, gender, geographical locations (urban and rural) and the PhD themed areas of acute care, early supported discharge and lifestyle-based interventions after stroke. Four PhD scholars taking part in the CDA-iPASTAR now work collaboratively with four stroke champions, supported by a wider PPI advisory panel.

Methods

This study will evaluate the process and impact of embedding PPI during a PhD program. We will conduct a longitudinal mixed-methods evaluation, conducting focus groups at 24, 36, and 48 months to explore the experiences of the key stakeholders involved. The participants will include PhD scholars, PPI partners (PPI Advisory Group and PPI Champions), PhD supervisors and a PPI manager. An independent researcher will conduct the evaluation. We will include focus groups, individual interviews and participant reflections. Qualitative data will be analyzed using thematic and content analysis, quantitative data will be analyzed using descriptive statistics.

Discussion

PPI and patient voice initiatives bring together researchers, family, and people with health care issues into meaningful dialogue and allow the development of a patient-voice learning network. Embedding PPI training within a PhD program can build meaningful capacity in PPI partnerships in stroke research.
Understanding the sexual and reproductive health needs of immigrant adolescents in Canada: A qualitative study
Authors: Meherali Salima , Louie-Poon Samantha , Idrees Sobia , Kauser Samar , Scott Shannon , Salami Bukola , Valliantos Helen , Meherali Kainat Moez , Patel Krishan , Suthar Puja , Akbarzada Zohra , Marcus Ivan , Khangura Manjot , Mangat Abneet
Published: July 2022

Background

Literature suggests that immigrant adolescents receive limited sexual and reproductive health (SRH) education and rarely utilize SRH services in Canada. This study sought to explore the SRH information needs of immigrant adolescents in the province of Alberta.

Methods

A qualitative descriptive methodology was undertaken to conduct 21 individual interviews with immigrant adolescents in Alberta.

Results

A total of four themes emerged from the interviews: (1) Barriers to SRH; (2) needs of adolescents regarding SRH; (3) sources of knowledge; and (4) strategies to improve SRH. Our findings document the conflicting needs and preferences between adolescents and their parents regarding access to SRH resources and services.

Discussion

Adolescents often felt unprepared to deal with their SRH issues due to socio-cultural barriers and conflicts with their parents' conservative attitude toward SRH concerns. Structural barriers to accessing SRH resources and services were also reported, including the location and cost of services. As a result, the majority of adolescents relied on digital methods to receive SRH information.

Conclusion

This study highlights that future research and SRH service provider efforts need to remain cognizant of the positionality of immigrant adolescents and explore innovative ways to deliver SRH resources and services that meet their unique needs.
Algorithms for Large Scale Additive Manufacturing in a Free-Flying Environment
Authors: Tauscher Oliver , Jonckers Declan , Thakur Aditya R.
Published: July 2022

Large scale additive manufacturing (LSAM) refers to the fabrication of structures that exceed the build volume of conventional additive manufacturing setups. This can be used for in-space manufacturing (ISM), facilitating the production of large functional structures in space which cannot fit within the payload fairing of a launcher system. In this paper, a new approach for a continuous fabrication process of structural elements is presented, combining the reach of a free-flying satellite and a robotic arm, utilizing a fused filament fabrication (FFF) 3D-printing setup. A motion planning algorithm was developed which calculates energy-efficient movement trajectories based on a truss design input combined with the movement constraints of the satellite and robotic arm. Using this printing paradigm, a long support-free truss was manufactured. This approach was further elevated by extending the truss structure along the second planar axis, thus facilitating the manufacture of structures larger than generally possible through a layer-by-layer approach. Subsequently, combining the segmented and continuous printing approach, a planar truss structure was produced.
“From everything to nothing in a split second”: Elite youth players' experiences of release from professional football academies
Authors: McGlinchey Thomas Ryan , Saward Chris , Healy Laura Catherine , Sarkar Mustafa
Published: July 2022

Previous research has assessed the affects release from football academies has on psychological distress and athletic identity of players. However, there has been no qualitative research exploring players' experiences of the release process. This study retrospectively explored players' lived experiences of being released from a professional football academy, having completed a scholarship (from ages 16–18). Four male football players (age 21.6 ± 1.5 years) who had experienced release from professional academies participated in in-depth semi-structured interviews. Data were analyzed using Interpretative Phenomenological Analysis. Four super-ordinate themes were interpreted from the data: Foreshadowing release—“left out in the cold”, The process of release, Support during the process of release and New beginnings—“there's a bigger world than just playing football every day”. Players reported that their contract meeting was a traumatic experience, and they experienced psychological difficulties in the longer-term following release. Factors that compounded the players' release were: a lack of aftercare being provided by the players' professional clubs for their wellbeing, and a disuse of social support, which hindered their transition out of full-time football. Context relevant recommendations are made to help improve the release process for elite youth football players.
A screening instrument for side dominance in competitive adolescent alpine skiers
Authors: Westin Maria , Norlén Annelie , Harringe Marita L. , Werner Suzanne
Published: July 2022

Previous research has shown that high school ski students injure their left anterior cruciate ligament (ACL) more often than their right ACL, and that a prevention program focusing on equal load to the right and left ski turns prevents ACL injuries. Whether the injuries were in the dominant or non-dominant side of ski students was not determined but may be important knowledge to ski coaches for future design of ski-specific training programs. There is no gold standard on how to investigate the dominant side of alpine skiers. Therefore, the aim of this study was to develop a screening instrument consisting of five questions for identifying side dominance and to evaluate side dominance in competitive adolescent alpine skiers. First, 121 competitive adolescent alpine skiers answered the questions on side dominance using a test-retest design. The questions were: which hand/arm (left/right) or foot/leg (left/right) one uses as the first choice when writing, throwing, kicking a ball, jumping over a fence and stair-climbing. A question about safer/better ski turn to the left or to the right was also added. Second, 274 skiers answered the questions at one occasion. A very good agreement was shown in writing and throwing and kicking a ball, and a fair agreement was shown in jumping over a fence and stair climbing. A total of 243 skiers reported right-sided dominance, and seven skiers reported left-sided dominance. One hundred and nineteen of the 121 skiers who took part in the test-retest design answered the question safer/better ski turn, and of those 70 (59%) reported that they had a safer/better ski turn to one side than to the other side. However, the side was not consistent between the two test occasions, and the question did not correlate with side dominance. A combination of the three questions “What hand/arm do you use as first choice when writing?” “What hand/arm do you use as first choice when throwing?” and “What foot/leg do you use as first choice when kicking a ball?”, may be used to decide side dominance in adolescent alpine skiers. Most adolescent alpine skiers reported right-sided dominance.
Physicochemical, rheological and structural properties of flours from six quinoa cultivars grown in Colombia
Authors: García-Parra Miguel , Polo-Muñoz María Paula , Nieto Calvache Jhon Edinson , Agudelo-Laverde Lina Marcela , Roa-Acosta Diego Fernando
Published: July 2022

Background

Inclusion of quinoa in the diet of consumers has generated a challenge for quinoa producers and food processors, which involves the study of new cultivars and the functional properties of their flours.

Methods

Six quinoa cultivars (Titicaca, Blanca real, Soracá, Pasankalla, Puno and Nariño) were analyzed for their proximate composition using the methodologies proposed by the Association of Official Analytical Collaboration, AOAC. A rheological analysis was carried out with flours from each cultivar. A sequential test including a flow test, a pasting test and another flow test was programmed to evaluate the flow behavior before and after a heating process. In addition, the structural properties of the cultivar flours were evaluated by Fourier Transform Infrared spectroscopy (FTIR).

Results

It was found that the Pasankalla, Titicaca and Soracá cultivars had a higher (p < 0.05) protein content, while the Puno, Pansakalla and Blanca real cultivars stood out for their higher (p < 0.05) lipid content. On the other hand, it was found that before heating, all quinoa flour dispersions had a dilatant flow (n > 1), but after heating, all of them showed a decrease of index values, where the flours of the Titicaca and Pasankalla cultivars were more affected with a tendency toward a Newtonian flow (n ≈ 1). The pasting test showed that the viscosity varied according to the cultivar tested. It is noteworthy that both Titicaca and Soracá presented a high peak viscosity (0.16 ± 0.01 and 0.13 ± 0.02 Pa·s respectively) and different setback values on cooling (0.100 ± 0.028 and 0.01 ± 0.01 Pa·s respectively). Spectroscopic analysis showed a direct relationship between the intensity of the peaks and the nutritional content of the flours. In addition, secondary protein structures such as β-sheet, β-Turn, α-Helix and Random Coil were identified after deconvolution of the spectra. The differences in the protein structures of each cultivar could allow their identification by this methodology.

Conclusion

It can be concluded that quinoa flours from the six cultivars could be used for the formulation of different food products, such as beverages, baked goods, snacks, pasta and others, acting as nutritional improvers and modifiers of rheological, textural and functional properties.
Combination of cassava starch biopolymer and essential oils for coating table eggs
Authors: Oliveira Gabriel da Silva , McManus Concepta , Pires Paula Gabriela da Silva , dos Santos Vinícius Machado
Published: July 2022

This work aimed to evaluate the eggshell microbiota and the internal egg quality after coatings with cassava starch biopolymer enriched with different essential oils during 35 days of storage at 20°C. A total of 369 brown table eggs were used and distributed in the following treatments: uncoated eggs, coated with cassava starch + Ginger essential oil (CS+GIN), cassava starch + Lemongrass essential oil (CS+LEM), and cassava starch + Tahiti lemon essential oil (CS+TAH). The count of total aerobic mesophilic bacteria on coated eggshells at 0 and 35 days of storage were similar to each other (mean 0.70 ± 0.37 and 0.91 ± 0.22 log10 CFU/mL) and significantly lower compared to uncoated eggs (2.21 ± 0.17 and 3.17 ± 0.22 log10 CFU/mL), in that order. On the 35th day, coated eggs showed similar Haugh unit (HU) values between them (mean 70.61 ± 5.35; classified as A - high quality) and significantly higher than uncoated eggs (51.60 ± 4.28; classified as B - average quality). Cassava starch coatings added with essential oils preserved the internal quality of the eggs during storage for 5 weeks at 20°C, reducing the eggshell microbiota and effectively keeping it at low levels during storage.
Does Abnormal Preoperative Coagulation Status Lead to More Perioperative Blood Loss in Spinal Deformity Correction Surgery?
Authors: Li Zheng , Yu Bin , Zhang Jianguo , Shen Jianxiong , Wang Yipeng , Qiu Guixing , Cheng Xinqi
Published: July 2022

This study aims to analyze the potential association between the preoperative coagulation status and perioperative blood loss in spinal deformity correction surgery. The preoperative coagulation status and estimated blood loss (EBL) during operation, postoperative wound drainage, and allogeneic transfusion during and after operation were recorded and analyzed. Among the 164 patients, 26 had a longer prothrombin time (PT), 13 had a lower fibrinogen level, 55 had a longer activated partial thromboplastin time (APTT), and 2 had a longer thrombin time (TT), and the platelet count (PLT) was all normal or higher than the normal level. The mean EBL per surgical level was 77.8 ml (range, 22–267 ml), and the mean drainage per surgical level was 52.7 ml (range, 7–168 ml). Fifty-five patients and 12 patients underwent allogeneic transfusion during and after the operation, respectively. The differences in EBL per surgical level, mean drainage per surgical level, the occurrences of allogeneic transfusion during and after operation between the patients with a longer PT, lower fibrinogen level, longer APTT or longer TT, and the normal controls were not significant (all P’s > 0.05). The Spearman correlation analysis showed that there was no correlation between PT, fibrinogen, APTT, TT or PLT with EBL per surgical level, mean drainage per surgical level, or allogeneic transfusion during and after the operation (all P’s > 0.05). The abnormal preoperative coagulation status but not hemophilia does not lead to more perioperative blood loss or a higher rate of perioperative allogeneic transfusion in spinal deformity correction surgery.
Spermatic cord anastomosing hemangioma mimicking a malignant inguinal tumor: A case report and literature review
Authors: Zhang Zhan-yi , Hong Peng , Deng Shao-hui , Tang Shi-ying , Liu Zhuo , He Hui-ying , Ma Lu-lin , Zhang Shu-dong , Tian Xiao-jun
Published: July 2022

Background

Anastomosing hemangioma (AH) is a rare vascular tumor and occurs in various organs. It is difficult to distinguish AH from malignant tumors even through multimodal imaging examination. AH located in the inguinal region is even rare. We present the diagnosis and treatment of a patient with spermatic cord AH in detail and conduct a literature review.

Case Report

An 84-year-old Chinese man had swelling pain in his right scrotum. A hard and fixed mass was palpable in the right inguinal region. Preoperative radiological examination considered it a neurogenic or vascular tumor. Malignant soft tissue sarcoma could not be excluded. He underwent radical inguinal right orchiectomy under intraspinal anesthesia. The diagnosis of spermatic cord AH was confirmed by pathological examination. The patient recovered uneventfully and remained disease-free during an 18-month follow-up.

Conclusion

Spermatic cord AH is quite rare and could be misdiagnosed as a malignant tumor. Pathological evidence might be necessary. The optimal choice of treatment should be determined through a comprehensive assessment of both tumor and patient factors.
Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit Models In Vitro and In Vivo
Authors: Pla Laura , Kühne Britta Anna , Guardia-Escote Laia , Vázquez-Aristizabal Paula , Loreiro Carla , Flick Burkhard , Gratacós Eduard , Barenys Marta , Illa Miriam
Published: July 2022

The rabbit model is gaining importance in the field of neurodevelopmental evaluation due to its higher similarity to humans in terms of brain development and maturation than rodents. In this publication, we detailed 14 protocols covering toxicological relevant endpoints for the assessment of neurodevelopmental adverse effects in the rabbit species. These protocols include bothin vitroandin vivotechniques, which also cover different evaluation time-points, the neonatal period, and long-term examinations at postnatal days (PNDs) 50–70. Specifically, the protocols (P) included are as follows: neurosphere preparation (GD30/PND0; P2) and neurosphere assay (P3), behavioral ontogeny (PND1; P4), brain obtaining and brain weight measurement at two different ages: PND1 (P5) and PND70 (P12), neurohistopathological evaluations after immersion fixation for neurons, astrocytes, oligodendrocytes and microglia (PND1; P6-9) or perfusion fixation (PND70; P12), motor activity (P11, open field), memory and sensory function (P11, object recognition test), learning (P10, Skinner box), and histological evaluation of plasticity (P13 and P14) through dendritic spines and perineuronal nets. The expected control values and their variabilities are presented together with the information on how to troubleshoot the most common issues related to each protocol. To sum up, this publication offers a comprehensive compilation of reliable protocols adapted to the rabbit model for neurodevelopmental assessment in toxicology.
Effect of Maternal Sildenafil Supplementation During Gestation on the Reproductive Performance of Sows/Gilts and Growth Performance of Neonatal Piglets
Authors: Wang Yue , Qin Yusheng , Zhao Wei , Yao Fusheng , Wang Wenjing , Hu Xiao , Cheng Linghua , An Lei , Tian Jianhui
Published: July 2022

Sildenafil, a phosphodiesterase 5 (PDE-5) inhibitor, provides an alternative and effective strategy to increase uterine blood flow and vascular development, thus improving fetal development. Previous studies have shown that sildenafil attenuates fetal growth restriction in rodents, sheep, and humans. However, the effect of sildenafil intervention on fetal growth in pigs remains unclear. This study aims to evaluate the effect of dietary supplementation with sildenafil on the reproductive performance of sows and gilts. Over 700 Landrace × Large White crossbred sows in the 3rd or 4th parity were randomly assigned to the control group and the sildenafil treatment groups. In brief, sows in the treatment groups were given a basic diet supplemented with sildenafil (0.32 g/day) during different stages of gestation: (1) gestation day (GD) 0–110; (2) GD 0–30; (3) GD 30–80; (4) GD 80–110; and (5) GD 30–110. At parturition, the total number of piglets born per litter, the number of piglets born alive or dead, the average birth weight, the number of weaned piglets, and the average weaning weights were recorded and analyzed. Sildenafil supplementation throughout gestation (GD 0–110) increased both the litter size and the average birth weight. To reduce the cost of extended sildenafil supplementation, time-phased strategies were further tested. Sildenafil supplementation during early gestation (GD 0–30), mid-gestation (GD 30–80), and late gestation (GD 80–110) partially improved litter performance. Notably, sows fed sildenafil supplementation from the mid-to-late gestation period (GD 30–110) showed significantly improved litter performance, approaching the levels in the sows supplemented with sildenafil throughout the whole gestation period. Taken together, our results showed that maternal sildenafil supplementation during gestation can effectively improve the reproductive performance of sows and gilts, and enhance the growth performance of neonatal piglets, thus providing a promising and practical intervention strategy to improve reproductive management in pig farming.
Molecular characterization of carnivore protoparvovirus 1 circulating in domestic carnivores in Egypt
Authors: Ndiana Linda A. , Lanave Gianvito , Zarea Aya A. K. , Desario Costantina , Odigie Eugene A. , Ehab Fouad A. , Capozza Paolo , Greco Grazia , Buonavoglia Canio , Decaro Nicola
Published: July 2022

Canine parvovirus (CPV) and feline panleukopenia virus (FPV), now included in the unique species Carnivore protoparvovirus 1 (CPPV1), have been circulating in dogs and cats for several decades and are considered the causes of clinically important diseases, especially in young animals. While genetic evidence of the circulation of parvoviruses in Egyptian domestic carnivores has been provided since 2016, to date, all available data are based on partial fragments of the VP2 gene. This study reports the molecular characterization of CPPV strains from Egypt based on the full VP2 gene. Overall, 196 blood samples were collected from dogs and cats presented at veterinary clinics for routine medical assessment in 2019 in Egypt. DNA extracts were screened and characterized by real-time PCR. Positive samples were amplified by conventional PCR and then were sequenced. Nucleotide and amino acid changes in the sequences were investigated and phylogeny was inferred. Carnivore protoparvovirus DNA was detected in 18 out of 96 dogs (18.8%) and 7 of 100 cats (7%). Phylogenetic analyses based on the full VP2 gene revealed that 9 sequenced strains clustered with different CPV clades (5 with 2c, 2 with 2a, 1 with 2b, and 1 with 2) and 1 strain with the FPV clade. All three CPV variants were detected in dog and cat populations with a predominance of CPV-2c strains (7 of 18, 38.9%) in dog samples, thus mirroring the circulation of this variant in African, European, and Asian countries. Deduced amino acid sequence alignment revealed the presence of the previously unreported unique mutations S542L, H543Q, Q549H, and N557T in the Egyptian CPV-2c strains.
Designing Reinforcement Learning Algorithms for Digital Interventions: Pre-Implementation Guidelines
Authors: Trella Anna L. , Zhang Kelly W. , Nahum-Shani Inbal , Shetty Vivek , Doshi-Velez Finale , Murphy Susan A.
Published: July 2022

Online reinforcement learning (RL) algorithms are increasingly used to personalize digital interventions in the fields of mobile health and online education. Common challenges in designing and testing an RL algorithm in these settings include ensuring the RL algorithm can learn and run stably under real-time constraints, and accounting for the complexity of the environment, e.g., a lack of accurate mechanistic models for the user dynamics. To guide how one can tackle these challenges, we extend the PCS (predictability, computability, stability) framework, a data science framework that incorporates best practices from machine learning and statistics in supervised learning to the design of RL algorithms for the digital interventions setting. Furthermore, we provide guidelines on how to design simulation environments, a crucial tool for evaluating RL candidate algorithms using the PCS framework. We show how we used the PCS framework to design an RL algorithm for Oralytics, a mobile health study aiming to improve users’ tooth-brushing behaviors through the personalized delivery of intervention messages. Oralytics will go into the field in late 2022.
Biostimulatory Response of Easily Extractable Glomalin-Related Soil Protein on Soil Fertility Mediated Changes in Fruit Quality of Citrus
Authors: Liu Xiao-Qing , Xie Ya-Chao , Li Yan , Zheng Li , Srivastava Anoop Kumar , Hashem Abeer , Abd_Allah Elsayed Fathi , Harsonowati Wiwiek , Wu Qiang-Sheng
Published: July 2022

Arbuscular mycorrhizal fungi secrete glomalin deposited into the soil as glomalin-related soil protein (GRSP), which possess multiple utility to benefit both soil as well as plant health. The present study aimed to assess the effects of the foliar application of an easily extractable GRSP (EE-GRSP) on the fruit quality, soil nutrients, and soil structural changes in three important citrus varieties (Satsuma mandarin Oita 4, Newhall navel orange, and Cocktail grapefruit). The exogenous EE-GRSP significantly elevated root mycorrhizal fungal colonization and soil hyphal length in Newhall and Oita 4 varieties, but without any such response in Cocktail grapefruit variety. The foliar spray of the EE-GRSP improved different external (e.g., pericarp, sarcocarp, and single fruit weight) and internal (e.g., soluble solids, titratable acids, and sugar contents) qualities of fruits to varying magnitudes, depending on citrus variety, with a more prominent effect on Cocktail grapefruit. EE-GRSP-treated fruits of Newhall and Oita 4 were more suitable for processing than non-treated control because of a low fruit hardness. However, no significant effect of the EE-GRSP was observed on the internal quality parameters of Newhall. EE-GRSP-treated citrus trees represented higher soil available nutrients over control, to some extent, especially on Oita 4. The foliar application of the EE-GRSP also increased various GRSP fractions to varying proportions and improved the distribution of water-stable aggregates in the size fraction of 0.25–2 mm, thereby increasing the mean weight diameter, particularly in Newhall and Cocktail grapefruit varieties. These observations provided clues about the stimulatory role of the EE-GRSP through soil structure and nutrient pool-mediated improvements in fruit quality.