bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Long Soaking of Gibberellin and H2SO4 Concentration Level on Germination of Manila Sapodilla Seeds (Manilkara zapota (L.) Van Royen)
Authors: Kristiani Putri , Ritawati Sri , Eiffelt Julio , Rohmawati Imas
Published: January 2025

Manila Sapodilla (Manilkara zapota (L.) Van Royen). Generally known as a long-lived plant. Sapodilla plants are tropical plants which are quite widely distributed in Indonesia. All parts of the manila sapodilla plant can be used from the fruit, leaves and stems as traditional medicine and for making other preparations. However, one of the problems is that sapodilla seeds have a hard, waterproof skin layer, which causes sapodilla seeds to experience dormancy and have difficulty germinating. This research aims to determine the effect of gibberellin soaking time and H2SO4 concentration levels on the germination of manila sapodilla (Manilkara zapota (L.) Van Royen) seeds. This study used a completely randomized design with two factors, the first factor, namely the long soaking treatment for gibberellin (L), which consisted of 3 levels, namely soaking for 6 hours (L0), soaking for 12 hours (L1), and soaking for 18 hours (L0). L2). the second factor, namely the H2SO4 concentration (K), which consists of 4 levels, namely without H2SO4 (K0), 40% H2SO4 concentration (K1), 60% H2SO4 concentration (K2), 80% H2SO4 concentration (K3). Gibberellin soaking treatment with a soaking time of 6 hours gave the best effect on growth speed parameters (2.44%/day). Treatment with a H2SO4 concentration level of 80% gave the best effect, namely on the parameters of maximum growth potential (88.89%), germination power (86.67%), growth speed (2.88%/day), as well as on the parameters of seeds not growing as much as (13.33%). There was no interaction between the length of gibberellin soaking treatment and the level of H2SO4 concentration on all parameters observed.
Optimizing The Utilization of Arabica Coffe Grounds Extract on the Growth Perfomance of Tilapia (Oreochromis Niloticus)
Authors: Nisa Haerunnisaa , Diamahesa Wastu Ayu , Lestari Dewi Putri
Published: January 2025

Nile tilapia (Oreochromis niloticus) is a widely cultivated freshwater fish due to its adaptability to various environments and ease of breeding. Feed availability is a crucial factor in the success of tilapia cultivation. Quality feed plays a vital role in fish development and using effective feed management strategies can help reduce costs and improve growth outcomes. Previous studies have suggested that coffee grounds can enhance fish immunity and growth due to their antioxidant properties. This research aimed to investigate the impact of adding coffee grounds to commercial feed on the growth and survival of Nile tilapia. The study was conducted over 45 days using a completely randomized design with five treatments and three replications. Treatments included a control group (P1) and feed supplemented with 0.5g (P2), 1g (P3), 3g (P4), and 5g (P5) of coffee grounds per 100g of feed. The results indicated that the addition of coffee grounds significantly affected weight growth, with the highest growth observed in P5. However, no significant differences were found in length growth or specific growth rate (SGR) among treatments. Feed consumption was highest in P2, but feed conversion ratio (FCR) and feed utilization efficiency were most favorable in P5. Water quality parameters remained within optimal ranges throughout the study.
Preliminary Test of the Sensitivity of Colletotrichum spp. to Binahong Ethanol Extract (Anredera cordifolia)
Authors: Aminatuzzifah Putri , Bahri Syamsul , Sedijani Prapti
Published: January 2025

The agricultural sector in Indonesia, especially the horticultural subsector, plays an important role in the economy and food security. One of the leading commodities in horticulture is the chilli plant (Capsicum annuum), which is very susceptible to anthracnose disease caused by the fungus Colletotrichum spp. This study aims to test the inhibitory activity of ethanol extract from binahong (Anredera cordifolia) leaves against the growth of Colletotrichum spp. fungus as an alternative environmentally friendly disease control. The research was conducted using a completely randomised design (CRD) with variations in extract concentrations of 0%, 0.5%, 1%, 1.5%, 2%, and 2.5%, each of which was tested three times. The results showed that 2.5% concentration of binahong leaf extract produced the highest inhibitory activity of 70%, while 0.5% concentration showed 56% inhibition. This inhibitory activity was categorised as strong. ANOVA analysis showed significant differences between treatments (p < 0.05). These findings demonstrate the potential of binahong leaf extract as a biofungicide in the control of anthracnose disease in chilli plants, which may contribute to more sustainable and environmentally friendly agricultural practices.
Chromosomes Characteristics of Vegetable Fern (Diplazium esculentum) in Rinjani Mountain National Park
Authors: Pratiwi Elsa , Mertha I Gde , Sukarso A. A.
Published: January 2025

Vegetable fern (Diplazium esculentum) is one type of fern that is utilised by the Indonesian people as one of the food ingredients. Chromosomes are genetic information in cells that are the basic unit of life. The purpose of this study was to determine the number of chromosomes and mitotic index of vegetable spikes (D. esculentum) at various altitudes in Mount Rinjani National Park. The type of research is quantitative research that describes a situation using numbers factually, systematically and accurately quantitative data of vegetable fern chromosomes (D. esculentum). The method used in the research is Squash method. The results showed no difference in the number of chromosomes of vegetable spikes (D. esculentum) at an altitude of 292 masl, 538 masl, 703 masl and 1417 masl. The number of chromosomes of vegetable spikes at all altitudes 2n = 82 (diploid) x = 41. The mitotic index of vegetable spikes showed results that were not significantly different at altitudes of 292 masl, 538 masl, 703 masl and 1417 masl.
Analysis of Heavy Metal Mercury (Hg) Content in Nile Tilapia (Oreochromis niloticus) from Rawa Taliwang Lake West Sumbawa
Authors: Seftiyani Ditayara , Khairuddin Khairuddin , Kusmiyati Kusmiyati
Published: January 2025

Rawa Taliwang Lake is a place where various types of aquatic organisms (macroorganisms and microorganisms) occur biological processes. Industrial activities can lead to the emergence of pollutants that contaminate the environment, including air, land, and water, if industrial waste is not managed properly. Surface water, especially in lakes, is easily polluted by heavy metals such as mercury (Hg). Mercury (Hg) levels that exceed normal limits in fish can be an indicator of environmental pollution. The study aims to determine the levels of heavy metal mercury (Hg) in tilapia (Oreochromis niloticus) and to assess the safety of consuming the fish. Samples were analyzed using the Atomic Absorption Spectroscopy (AAS) method. The results showed that tilapia samples had mercury (Hg) levels of 0.1 mg/kg (ppm), but were still safe for consumption. In line with BPOM Number 9 of 2022 which sets the threshold for heavy metal mercury (Hg) contamination in processed food products at 0.50 mg/kg.
Optimization of Vaname Shrimp Growth (Litopenaeus vannamei) in Feeding with The Addition of Moringa Leaf Extract (Moringa oleifera Lam)
Authors: Naban Sulthon Hamid Faros , Lumbessy Salnida Yuniarti , Rahmadani Thoy Batun Citra
Published: January 2025

The addition of moringa leaf extract is one way to increase the production of vaname vaname shrimp farming. Moringa leaves are considered as feed supplements because they contain active compounds that are beneficial for shrimp growth. This study aims to analyze the growth of shrimp vaname on feeding supplemented with moringa leaf extract. The method used in this study is an experimental method using a complete randomized design (RAL) with 4 treatments and 3 repetitions.  Shrimp used is the size of PL 25 and maintained for 50 days parameters measured include absolute weight, absolute length, SGR, molting frequency, survival rate (SR) and water quality parameters. The Data obtained were analyzed by statistical ANOVA test and then tested by DUNCAN test, as well as descriptive water quality parameters in anasis. The results showed that phytochemical compounds identified in moringa leaf extract are flavonoids, alkaloids, saponins, tannins, and phenolics. The addition of moringa leaf extract with different extraction time in commercial feed affects the growth, molting frequency and survival rate of vaname shrimp, but does not affect the absolute length of vaname shrimp. Moringa leaf extract with 60 Minutes extraction time is the best treatment with antioxidant content of 66.78% and vitamin C 133.76 mg / 100g so that it can increase the absolute weight of vanname shrimp by 2.4 g, specific growth rate of 0.052% / day, molting frequency of 2.0 times / head and survival rate of 67%.
Exploration of P-Solubilizing and IAA-producing Rhizobacteria from Saline Environments: Their Effects on Vigna radiata Growth-promotion
Authors: Utami Ni Wayan Anggun Diah , Zulkifli Lalu , Rasmi Dewa Ayu Citra , Sedijani Prapti
Published: January 2025

Rhizobacteria that are able to dissolve P and produce IAA can be used as component of biofertilizers to help increase plant growth, which can be a more environmentally friendly fertilizer alternative compared to chemical fertilizers. Rhizobacteria originating from sub-optimal environments have the potential to overcome environmental stress such as osmotic stress. To obtain potential isolates that can be used as biofertilizer, exploration of the rhizosphere of the sentigi (Pemphis acidula) has been carried out from the coast of Gili Sulat, Lombok. The method for isolating and selecting IAA producing bacteria was carried out using the colorimetric test method, while for the P solubilization ability, it was carried out by growing rhizobacteria on Pikovskaya media. Isolate PA6 with the highest IAA producing ability (21 ppm) and PL4 with the highest P solubilizing ability (20.9 ppm), were tested for their effect on the growth-promotion of Vigna radiata cultured on Murphy agar media by measuring the parameters of plant height, root length, fresh weight, and plant dry weight. Based on the One Way ANOVA statistical analysis with a p value ≤ 0.05, it showed that the inoculation of IAA-producing and P solvent rhizobacteria was proven to be able to have a significant effect with significantly different results on increasing plant dry weight. In the future, the isolate obtained can be developed into a biofertilizer component that can be applied in saline and dryland agriculture.
Arvenses potenciales como cultivo trampa para Meloidogyne enterolobii y Nacobbus aberrans
Authors: Gómez-Rodríguez Olga , León-Tello Martha Ivone , Villar-Luna Edgar , Aguilar-Marcelino Liliana , Zuñiga-Mayo Víctor Manuel
Published: January 2025

El uso de arvenses como estrategia de manejo agroecológico de fitonematodos ha ganado importancia debido a su implementación como plantas trampa que interfieren en su ciclo biológico, por lo que el objetivo de la presente investigación fue evaluar el porcentaje de reproducción de Meloidogyne enterolobii y Nacobbus aberrans en cinco arvenses. Este experimento se llevó a cabo en el Colegio de Postgraduados, Campus Montecillo, Estado de México, México, en el año 2023. Se usó como referencia de susceptibilidad el genotipo de chile CM-334 (testigo) y cada unidad experimental fue inoculada con 1000 J2 de cada especie de nematodo. Las variables respuesta fueron agallamiento, masas de huevos, huevos, número de hembras y juveniles por g de raíz a los 35 días posteriores a la inoculación (dpi) para Meloidogyne enterolobii y 45 dpi para Na. Se utilizó un diseño experimental completamente al azar con arreglo factorial. Las arvenses Tagetes erecta, Portulaca oleracea, Dysphania ambrosioides, Malva parviflora y Oxalis corniculata presentaron un 100% de disminución en el número de agallas, masas de huevos y huevos por g de raíz para Nacobbus aberrans, con respecto al testigo. Estos dos últimos parámetros fueron similares para Meloidogyne enterolobii. Todas las arvenses evaluadas mostraron un porcentaje de reproducción diferencial para ambos nematodos en el número de hembras e individuos por g de raíz (7.34-100%). Los resultados obtenidos indican que estas arvenses pueden ser utilizadas como cultivo trampa potenciales para el manejo de los nematodos Meloidogyne enterolobii y Nacobbus aberrans.
Prácticas corporativas para la subsistencia: diversidad oeconomica del Colegio de San Juan de Letrán, 1770-1833
Authors: Ríos Zúñiga Rosalina
Published: January 2025

El objetivo del presente artículo es analizar algunas de las prácticas corporativas que se realizaban en el Colegio de San Juan de Letrán de la Ciudad de México entre 1770 y 1833, con el fin de mostrar de qué manera lograba obtener recursos de carácter secundario para su subsistencia. Las prácticas en las que nos enfocaremos son: la renta de niños para los entierros, la tabla de carne, la renta de lavaderos y la lotería. Se trataba de prácticas que daban sentido a una sociedad estamental, jerárquica y corporativa, pero también que sostenían una economía con un sentido más de tipo moral, donde lo más importante era la familia, la corporación; en una palabra, se trataba de una oeconomia.
Intelligent path planning technique for autonomous vehicles using improved harmony search optimized fuzzy control
Authors: Venkata Satya Rahul Kosuru  , Ashwin Kavasseri Venkitaraman
Published: January 2025

Path planning is one of the most crucial elements of autonomous driving (AD). Due to its capacity to directly make judgments based on observation and learn from the environment, learning-based path planning techniques are of interest to many academics. The standard reinforcement learning approach of the deep Q-network has made major strides in AD since the agent normally learns driving tactics simply by the intended reward function, which is difficult to adapt to the driving scenarios of urban roadways. However, such methodologies rarely use the global path data to address the problem of directional planning, like turning around at an intersection. In addition, the link between different motion instructions like these might easily lead to an erroneous prediction of the route orders due to the fact that the steering and the accelerator are independently governed in a real-world driving system. This research proposes and implements a Provisional Cross-layered Deep Q-Network (PC-DQN) for path planning in end-to-end autonomous vehicles, where the universal path is employed to direct the vehicles from the starting point to ending point. We employ the concept of Improved Harmony Search optimized fuzzy control (HIS-FC) and propose a defuzzification approach to increase the stability of anticipating the values of various path instructions in order to manage the reliance of distinct path instructions in Q-networks. We carry out extensive tests in the CARLA simulator and contrast our approach with cutting-edge approaches. The suggested strategy outperforms existing methods in terms of learning efficiency and driving reliability, according to experimental findings.
Comparison of knowledge, attitudes, and behaviors regarding breast self-examination among health and non-health students
Authors: Kaza Dity Wandari  , Astika Gita Ningrum  , Astika Gita Ningrum
Published: January 2025

Breast cancer is the most common cancer in Indonesia, with 65,858 new cases, and 68-73% of patients detect the disease at an advanced stage. However, early detection through Breast Self-Examination (BSE) can be performed independently without tools, ideally 7-10 days after menstruation in women aged ≥20 years. Despite its importance, BSE activities in educational contexts are predominantly targeted at health students, leaving non-health students with limited exposure. This research aims to determine the differences in knowledge, attitudes, and behaviors regarding BSE among health and non-health students at Universitas Airlangga. A quantitative analytical method with a comparative observational design and a cross-sectional approach was employed. The study was conducted among health and non-health students from the Universitas Airlangga class of 2022 using purposive sampling. Data were analyzed using the Chi-square test. The research results reveal significant differences between the groups. The knowledge p-value was 0.003, the attitude p-value was 0.001, and the behavior p-value was 0.000, indicating higher levels of knowledge, positive attitudes, and practices among health students compared to non-health students. Addressing disparities in BSE awareness and practices between these groups is crucial for promoting early detection of breast cancer. Future research should explore strategies to increase BSE awareness and behavior in non-health students to ensure more comprehensive public health outreach.
Prevalence of influenza in children presented in pediatric emergency department
Authors: Laureta Sadedini  , Gjeorgjina Kuli-Lito  , Numila Kuneshka  , Elda Skenderi  , Alberta Shkembi  , Diana Shtembari  , Anisa Gjika
Published: January 2025

Introduction. Seasonal influenza is an acute respiratory infection (ARI) of global importance caused by influenza viruses A and B. Each year, millions of children get sick: thousands of children are hospitalized, and some children die from flu. The aim of this study is primarily, to estimate the prevalence of influenza infection among children presented in the emergency department, secondary, to observe the clinical manifestations, complications and risk factors of influenza cases. Methods: This study was conducted from January to April 2024 at the University Hospital Centre: "Mother Theresa" Tirana, Albania. Children from 1month -14 years, with flu-like signs defined by CDC as fever plus cough or sore throat, were assessed for influenza disease using the RT-PCR test of nasopharyngeal (NHF) swab, and the results were compared. Results: From138 nasopharyngeal swabs examined 62(44.92%) resulted in influenza positive and 76(55.07%) influenza negative. About the types 43(69.35%) were type A and 19(30.65%) Type B, 32(74.41%) were A H1 and 11(17.74%) were AH3. There was no significant difference in almost all data between two groups (p>0.05) The most common complication was viral pneumonia 13(41.9%). Overall, this research shows a good correlation between ARIs and influenza viruses. Conclusions: Even though, a lot of study, especially in high income countries, have proven the benefits of influenza vaccines on ARIs, recently there has been noted a low rate of vaccination and a rising trend of influenza cases worldwide- so that, we believe they should take into consideration introducing the influenza vaccine in the main vaccination scheme.
Agility in aviation management: Evaluations from a supply chain perspective
Authors: Gülşah ŞİŞMAN
Published: January 2025

This paper examines the concept of agility within aviation management, emphasizing its role from a supply chain perspective. Drawing from a comprehensive literature review, the study identifies how agility is defined, applied, and analyzed in the aviation sector. Key themes encompass the significance of agile supply chains in achieving operational adaptability, the incorporation of digital tools, and the strategies employed to address disruptions, exemplified by the COVID-19 pandemic. The paper identifies research gaps, including limited attention to sustainability and challenges in stakeholder collaboration. By synthesizing insights from previous studies, this paper provides a framework for understanding the strategic importance of agility in aviation management and offers directions for future research to build resilient and adaptive supply chains.
Effects of pregnancy-related anxiety on pregnancy outcomes
Authors: Rahmi Andrita Yuda
Published: January 2025

Introduction: Maternal anxiety during pregnancy has been associated with various adverse birth outcomes, including alterations in Brain-Derived Neurotrophic Factor (BDNF) levels, birth weight, length, and APGAR scores. This study aims to examine the relationship between maternal anxiety levels and neonatal outcomes among pregnant women in Padang, Indonesia.
Methods: A cross-sectional study was conducted with 85 pregnant women who were approaching labor at a hospital in Padang. Anxiety levels were measured using the Zung Self-Rating Anxiety Scale (ZSAS), while neonatal outcomes such as birth weight, length, and APGAR scores were recorded. BDNF levels were measured using the ELISA method. Statistical analysis was performed using Pearson correlation and One-Way ANOVA tests to assess the relationship between anxiety levels and neonatal outcomes.
Results: The results showed that 84.5% of participants experienced anxiety, with 40% having moderate anxiety and 27.1% having severe anxiety. A significant association was found between maternal anxiety and BDNF levels (p = 0.000), with higher anxiety associated with lower BDNF. A weak but significant negative correlation was observed between maternal anxiety and baby length (r = -0.224, p = 0.039). A strong negative correlation was identified between anxiety and APGAR scores (r = -0.661, p = 0.000). However, no significant relationship was found between maternal anxiety and birth weight (r = -0.121, p = 0.270).
Conclusions: Maternal anxiety significantly influences BDNF levels, baby length, and APGAR scores but does not significantly affect birth weight. These findings underscore the importance of addressing maternal mental health during pregnancy and implementing interventions to reduce anxiety for better neonatal outcomes.
Acute appendicitis complicated by ileocolic vein thrombosis with a unique coagulation profile: A case report
Authors: Dr Azeez Palol  , Dr Dawood khan  , Dr Danish Ali Khan  , Dr Alanoud Saleh  , Dr Nabeel Shareef Mahmood  , Dr Saeed Takish Saeed  , Dr Naseem Ambra
Published: January 2025

In the realm of common surgical emergencies, acute appendicitis rarely surprises clinicians. However, this case report explains an exceptional discovery in a 46-year-old man presenting with seemingly routine appendicitis at Hamad International Hospital, Doha, Qatar.

Contrast-enhanced CT imaging revealed not only a perforated appendix but also ileocolic vein thrombosis with unique coagulation profile - a case presentation previously rarely documented in medical literature. This report highlights the critical role of comprehensive diagnostics and the need for vigilance in seemingly straightforward cases, potentially reshaping our approach to acute appendicitis management.
A review on cancer vaccines: Current developments and future prospects
Authors: J.V.S. CHANDANA  , J. RENU  , E. SWATHI  , D. VARSHA  , T. RAMARAO
Published: January 2025

Tumour immunotherapy has made tremendous progress in the past decades, with numerous studies entering the clinical evaluation. The cancer vaccine is considered a promising therapeutic strategy in the immunotherapy of solid tumours. Cancer vaccines stimulate antitumor immunity using tumour antigens, which can be delivered as whole cells, peptides, nucleic acids, etc. An ideal cancer vaccine would be able to overcome tumour immunosuppression and induce both humoral and cellular immunity. The use of cancer vaccines is considered a promising therapeutic strategy in clinical oncology, which is achieved by stimulating anti-tumour immunity with tumour antigens delivered in the form of cells, peptides, viruses and nucleic acids. The ideal cancer vaccine has many advantages, including low toxicity, specificity, and induction of persistent immune memory to overcome tumour heterogeneity and reverse the immunosuppressive microenvironment. Cancer treatment is done by surgery,chemotherapy,radiation therapy. These treatments may cure early-stage cancer, but are often ineffective in treating advanced or recurrent cancer. Basic and clinical studies of the tumour microenvironment, which consists of cancer cells, stromal cells, and immune cells, have demonstrated the important role of antitumor immunity in cancer development and progression. Cancer immunotherapy has been proposed as a fourth cancer treatment option. In particular, the clinical application of immune checkpoint inhibitors, such as anti-CTLA-4 and anti-PD-1/PD-L1 antibodies, to various types of cancer represents a major advance in cancer treatment. Indeed, several issues remain to be solved to improve their clinical efficacy; these include low cancer cell antigenicity and poor infiltration and/or accumulation of immune cells in the cancer microenvironment.
Motivasi Peternak dalam Beternak Ayam Kampung di Pulau Moa Kecamatan Moa Kabupaten Maluku Barat Daya
Authors: Eoh Briand Ringga Saputra , Lainsamputty Jecklin M. , Jesajas Heryanus
Published: January 2025

Penelitian ini bertujuan untuk mengetahui motivasi peternak dalam beternak ayam kampung di Pulau Moa Kecamatan Moa Lakor Kabupaten Maluku Barat Daya. Pada bulan Mei 2024, penelitian ini dilaksanakan di Kelurahan Tiakur, Desa Patti, dan Desa Klis yang berada di Kecamatan Moa, Kabupaten Maluku Barat Daya. Metode yang digunakan dalam penelitian ini adalah survei. Data dikumpulkan dengan menyebarkan kuesioner kepada para peternak di Pulau Moa, Kecamatan Moa Lakor, Kabupaten Maluku Barat Daya dengan masing-masing peternak minimal 10 orang Peternak. Penelitian ini dilaksanakan dengan melakukan pendekatan dengan Kepala Lurah dan Kepala Desa secara langsung, setelah itu peneliti dapat menemui Peternak yang ada di lokasi penelitian tersebut untuk dapat mengambil data melalui kuesioner yang di sebar pada Peternak. Parameter atau variabel yang diukur dalam penelitian ini adalah tingkat motivasi peternak terdiri dari motivasi ekonomi, sosial dan hiburan. Hasil penelitian menunjukkan bahwa faktor ekonomi, sosial, dan hiburan secara simultan berpengaruh signifikan terhadap motivasi peternak. Faktor ekonomi dan sosial secara parsial berpengaruh signifikan terhadap motivasi peternak, sedangkan faktor hiburan tidak signifikan. Variabel independen seperti faktor ekonomi, faktor sosial, dan faktor hiburan pengaruhnya sebesar 57,23%, sedangkan sisanya 42,77% dipengaruhi oleh variabel lain yang tidak dimasukkan ke dalam model ini.
Studi Populasi Monyet Ekor Panjang (Macaca fascicularis) di Taman Wisata Alam Madapangga
Authors: Cahyadin M. , Hadi Islamul , Ichsan Andi Chairil
Published: January 2025

Taman Wisata Alam Madapangga merupakan tipe ekosistem hutan dataran rendah yang dicirikan dengan topografi yang bergelombang serta jenis  flora dan fauna khas yang ada didalamnya. Kondisi kawasan ini masih relatif baik dengan keanekaragaman hayati yang dimilikinya salah satunya monyet ekor panjang (Macaca fascicularis). penelitian ini bertujuan untuk mengetahui ukuran populasi monyet ekor panjang (Macaca fascicularis) di Taman Wisata Alam Madapangga. Dengan dilakukannya penelitian studi populasi monyet ekor panjang (Macaca fascicularis)  dapat memberikan informasi mengenai populasi monyet ekor panjang yang ada di tempat tersebut. Penelitian dilakukan pada bulan Agustus 2022 sampai dengan bulan September 2022 di kawasan Taman Wisata Alam Madapangga Kabupaten Bima. Pengambilan data dimulai pada pagi hari sampai sore hari menggunakan metode reconnaissance. Data yang diperoleh menunjukan pada jalur jalan raya berjumlah 106 individu, jalur blok pemanfaatan berjumlah 12 individu, jalur batas kawasan denga lahan persawahan berjumlah 28 individu, dan jalur blok perlindungan berjumlah 15 individu. Jumlah keseluruhan 161 individu. Nilai sex ratio pada setiap kelompok menunjukan nilai yang bervariasi. Sex ratio pada setiap kelompok Monyet ekor panjang di Taman Wisata Alam Madapangga berkisar antara 1 : 1,6 sampai 1 : 3,3. Menurut Swindler (1998 cit. Sopana, 2018) jumlah individu betina dewasa yang lebih banyak dibandingkan dengan jantan dewasa dapat mengurangi adanya kompetisi antara jantan pada setiap kelompok. kompoosisi kelompok umur monyet ekor panjang (Macaca fascicularis) dikawasan Taman Wisata Alam Madapangga terdiri dari dewasa 79 individu, remaja 52 individu, anak 30 individu.
Dosage Forms of Drugs Used in Psychiatry
Authors: Anokhina M. V. , Goncharenko A. Yu. , Kozlovskii V. L.
Published: January 2025

Background: despite the wealth of dosage forms in modern pharmaceuticals, patients with mental pathology mainly use oral forms of drugs. The aim of article is to present the state of the art on practical administration of different drug forms in clinical psychiatry. Method: assessment and discussion of registered drug forms of original substances significance capable to increase the treatment effectiveness. Results: tablet forms are the most relevant in psychiatry, but they are also very diverse: from oral dispersible tablets to film-coated tablets with modified release of the active substance. However, manufacturers do not specifically emphasize the specifics of using a particular dosage form in psychiatry. For patients with chronic disorders, when carrying out long-term basic therapy, long-acting parenteral drugs are used, manufactured using modern technologies that make it possible to control the release of the substance in the current daily dose for weeks and a month after a single consuming. Conclusion: the use of oral forms of drugs may be important for monitoring compliance in patients in hospital settings, and long-acting forms are relevant for treating patients in outpatient practice.
Cariprazine and Aripiprazole in inpatient schizophrenia therapy. Comparative analysis of the parameters of the effectiveness and safety of antipsychotics
Authors: Ivanov M. V. , Stanovaya V. V. , Moritz A. A. , Terebova P. S.
Published: January 2025

Background: the drugs cariprazine and aripiprazole, from the group of third-generation antipsychotics, are recommended for both inpatient and outpatient treatment of schizophrenia, primarily to correct negative symptoms and minimize the risk of endocrine side effects caused by previous generations of drugs. The relevance of this study is due to the lack of research, including data from domestic psychiatric practice. The objectives of this research are to conduct a direct comparison of the effcacy and safety profiles of cariprazine and aripiprazole for the treatment of schizophrenia. Eliminating this information gap will undoubtedly contribute to optimizing the therapeutic process by personalizing the choice of antipsychotic medication. The aim of this study is to compare the therapeutic efficacy and safety of cariprazine versus aripiprazole during inpatient treatment for schizophrenia. Patients and Methods: an eight-week observational study was conducted at the V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology. Thirty-eight inpatient patients participated in the study, including 20 men and 18 women, aged 18 to 68 years, with a diagnosis of paranoid schizophrenia (F20.0) who had a positive response to therapy (at least a 30% reduction in total score on the Positive and Negative Syndrome Scale [PANSS]). Two groups of patients were formed based on monotherapy with atypical antipsychotics of the third generation: group I received cariprazine, and group II received Aripiprazole. Clinical and psychopathological assessments, psychometric measurements (PANSS and UKU scales), anthropometric measurements, and laboratory tests were conducted. Statistical analysis was also performed. Results: the analysis of psychometric indicators in dynamics showed that in both groups, there was a significant reduction in symptoms, as measured by the total PANSS score, by 14.0 (95% CI (2.2–25.8), p = 0.026) and 12.0 (95% CI (3.4–20.6), p = 0.013), in the first and second groups respectively. At the same time, among patients taking cariprazine, the decrease in negative symptoms on the PANSS subscale was statistically significant, amounting to – 4.3 points (95% CI (–9.3 — –0.3), p = 0.039). During 8 weeks of aripiprazole therapy, no significant changes in metabolic parameters were observed. In contrast, in the group of patients receiving cariprazine, a reduction in body weight of 1.8 kg (95% CI (1.3–2.3), p < 0.001) and a decrease in total fat percentage of –2.3% (95% CI (–3.3 — 1.3), p < 0.001) were observed. Conclusions: the results of this study suggest that cariprazine monotherapy may be more effective than aripiprazole for treating negative symptoms. Both, cariprazine and aripiprazole, have shown good tolerability and a low risk of side effects.
THE USE OF ANIMATED VIDEOS FOR THE DEVELOPMENT OF MULTICULTURAL-BASED CHARACTER VALUES IN FRENCH LANGUAGE LEARNING
Authors: Rohali Rohali , Kusnawati Tri , Rahmawati Desi
Published: January 2025

The integration of character education into learning is essential. This study developed an animated video focusing on multicultural character values in French language education for high school students. It also described the character values that emerged in schools teaching French through these multicultural animated videos. Utilizing the action research and development (R&D) model proposed by Dick et al. (2005), the results indicated that three animated videos could effectively incorporate 11 character values for both classroom and out-of-class learning. These character values include religious faith, independence, tolerance, cooperation, discipline, curiosity, love of peace, hard work, nationalism, multiculturalism, and responsibility. These values are evident and fostered throughout the learning process.
Possibilities of implementation of personalized medicine using the genetic features of the vitamin D receptor
Authors: Turova L.O. , Vezhnovets T.A. , Kurchenko А.І. , Kopnov P.V.
Published: January 2025

The article investigated three polymorphic variants of the VDR vitamin D receptor gene (rs1544410, rs4516035 and TaqI (rs731236) in 347 people from different regions of Ukraine, aged from 1 to 69 years. The results showed variability in the frequencies of alleles and genotypes of VDR polymorphic variants. The objective: based on the data of genetic studies, to evaluate the variation of genotypes of VDR – the vitamin D receptor gene in the Ukrainian population.Materials and methods. VDR genotype was determined using the polymerase chain reaction (PCR) method and high-throughput exome sequencing (next generation sequencing – NGS) of a new generation on the Illumina’s HiSeq device (made in the USA). Buccal epithelium and saliva served as material for genotyping. The obtained digital data were processed statistically in the R environment. Results. It was established , that carriers of certain genetic variants of the VDR gene have an increased risk of vitamin D deficiency, which is extremely important for improving personalized prevention of vitamin D deficiency.Conclusions. Identification of carriers of mutations in the VDR gene will improve the quality of diagnostics, which will make it possible to provide personalized prevention of vitamin D insufficiency and deficiency and pathologies associated with this gene, as well as to stratify the population by risk groups at the preclinical stage.
Effective experience of treatment of diseases caused by human papillomaviruses in women of reproductive age
Authors: Beniuk V.O. , Heryak S.M. , Goncharenko V.M. , Hrynevych O.Yo. , Godlevska N.A. , Pyrohova V.I. , Revenko O.O. , Sukhanova A.A. , Shalko M.N.
Published: January 2025

Despite primary and secondary prevention measures and the natural course of human papillomavirus infection, which provides a long latent phase during which its development can be prevented, cervical cancer (CC) is still diagnosed in more than 500,000 women worldwide each year. At the same time, approximately 90% of cervical cancer cases and deaths from it are recorded in low- and middle-income countries.According to current guidelines, cervical cancer screening (WHO, 2018, 2021, 2022) includes testing for the presence of human papillomavirus (HPV) to detect precancerous conditions with subsequent prescription of appropriate treatment, which determines the relevance of studies conducted using the original Ukrainian drug with a direct antiviral effect on papillomavirus – proteflazid, in particular in the form of suppositories for vaginal use.The objective: to analyze the experience of using proteflazid (suppositories and drops) for diseases of the genital organs in women of reproductive age caused by HPV.Materials and methods. An analysis of publications with data from clinical studies was conducted, in which over a ten-year period, approaches to the treatment and prevention of papillomavirus infection with the drug proteflazid (suppositories) in women with cervical intraepithelial neoplasia – CIN I and CIN II were studied and their effectiveness was evaluated.Results. Clinical studies have established high effectiveness of treatment with medications based on the active substance proteflazid CIN of mild and moderate degrees, while a low level of toxicity has been proven. This allows it to be used even during pregnancy and breastfeeding.Conclusions. Proteflazid (drops and suppositories) is currently a medication for specific antiviral therapy of HPV infection with the aim of eradicating the papillomavirus in women with cervical intraepithelial neoplasia (CIN I and CIN II) against the background of HPV infection and with a positive HPV test with a normal cytological picture.When treating cervical epithelial dysplasia caused by papillomavirus infection with proteflazid (suppositories), normalization of the cytological picture or the transition of cervical intraepithelial neoplasia of class CIN II (moderate dysplasia) to class CIN I (mild dysplasia) is determined.The drug proteflazid (suppositories) helps to eliminate dysbiotic disorders of the genital tract microflora, restores the normal biotope of the vagina, accelerates the processes of restoration of the epithelium of the mucous membrane of the cervix, prevents recurrence of diseases.
«Да не будет чин архиерейства во уничижении от многаго времяни в трупном осмердении»
Authors: Bashnin Nikita V. , Ustinova Irina A.
Published: January 2025

В России для представителей высшего духовенства (патриарха, митрополитов, архиепископов и епископов) был предусмотрен особый Чин погребения. Согласно канонической традиции совершение обряда отпевания над носителем епископского сана мог осуществить лишь равный ему по духовному достоинству. В России середины XVII в. было всего 13 епархий, столицы которых были удалены друг от друга на сотни километров, и соответствующее количество архиереев. Кроме того, все вопросы с погребением представителей епископата решались непосредственно в Москве – патриархом и царем, поскольку похороны архиерея имели важное общественное значение и носили статусный характер. В статье показано, как эти особенности привели к складыванию парадоксальной практики длительной отсрочки в совершении обряда погребения над телом усопшего архиерея, продолжительность которой достигала иногда нескольких месяцев. Такая ситуация порождала беспокойство и дискуссии среди высшего духовенства. В статье рассмотрена переписка архиепископа Вологодского и Белозерского Симона начала 1670-х гг. с другими владыками о возможности совершения отпевания архиереев представителями епархиального духовенства. Исследование показало, что, несмотря на единодушие владык в этом вопросе, изменения в практику статусных похорон представителей высшего духовенства в XVII в. внесены не были.
HUBUNGAN USIA DAN LAMA MENIKAH TERHADAP KEBERHASILAN PROGRAM BAYI TABUNG DI RSUD. DR SOETOMO SURABAYA DAN RSIA PUTRI KLINIK TIARA CITA SURABAYA
Authors: Trianto Nur Ayafida Putri , Sa’adi Ashon , Erye Frety Endyka
Published: January 2025

Infertilitas merupakan ketidakmampuan pasangan untuk mencapai kehamilan selama setidaknya satu tahun ketika melakukan hubungan intim tanpa menggunakan alat kontrasepsi lainnya. Hasil Survey Demografi dan Kesehatan Indonesia (2018) mengatakan, pada tahun 2017 angka infertilitas di Indonesia adalah 12%-22% dari total populasi usia reproduksi, sebanyak 15% kasus terjadi pada wanita usia subur . Tujuan penelitian ini untuk menganalisis hubungan usia dan lama kawin pada pasangan suami istri terhadap keberhasilan program bayi tabung di Klinik Graha Amerta RSUD Dr. Soetomo dan RSIA Putri Klinik Tiara Cita Surabaya Tahun 2022. Penelitian ini adalah penelitian kuantitatif dengan menggunakan desain cross sectional. Sampelnya adalah wanita yang mengikuti program bayi tabung di Klinik Fertilitas Graha Amerta RSUD Dr. Soetomo dan RSIA Putri Klinik Tiara Cita Surabaya Tahun 2022 yang memenuhi kriteria inklusi dan ekslusi dengan menggunakan total sampling dengan jumlah 121 responden. Istrumen penelitian menggunakan data sekunder yang bersumber dari rekam medis pasien kemudian dianalisis menggunakan uji statistik non parametrik. Responden pada penelitian ini sebagian besar berusia 35-39 tahun, menikah > 5 tahun, kadar serum ?-Hcg <25 mIU/mL, kadar progesteron <80 nmol/L, dan gagal program IVF. Analisis uji mann whitney menunjukkan ada hubungan secara signifikan antara usia dengan keberhasilan program IVF (p=0,001) dan terdapat hubungan yang signifikan antara lama menikah dengan keberhasilan program IVF (p=0,015). Kesimpulan pada penelitian ini adalah terdapat hubungan yang signifikan antara usia dan lama menikah dengan keberhasilan program IVF, dukungan keluarga dan health belief dengan pemberian ASI eksklusif dimana  health belief  adalah yang paling dominan.
PENGARUH CORE STABILITY EXERCISE TERHADAP FUNGSI TRUNK DAN AKTIVITAS FUNGSIONAL PADA LANSIA PASCA STROKE
Authors: Handayani Retno , Sius Mariel Daba Sekar Sari
Published: January 2025

Stroke pada lansia menduduki peringkat kedua penyebab kematian dan kecacatan terbesar hampir diseluruh dunia serta menjadi masalah kesehatan global. Pasca stroke mayoritas pasien mengalami penurunan  fungsi trunk yang akan berpengaruh pada kemampuan fungsionalnya sehingga pasien akan mengalami kesuitan dalam melakukan gerakan-gerakan fungsional yang sangat dibutuhkan dalam aktivitas sehari-hari. Penurunan fungsi trunk juga menjadi penyebab buruknya postur pada pasien pasca stroke dan juga menyebabkan ketergantungan pasien. Penelitian ini bertujuan untuk mengevaluasi pengaruh pemberian latihan stabilitas inti dengan metode ADIM (Abdominal Draw in Manuever) terhadap fungsi trunk dan aktivitas fungsional pada lansia pasca stroke. Dua hipotesis utama diuji dalam penelitian ini: pertama, apakah latihan stabilitas inti berdampak signifikan terhadap fungsi trunk pada lansia pasca stroke; dan kedua, apakah latihan stabilitas inti berdampak signifikan terhadap aktivitas fungsional pada lansia pasca stroke. Penelitian ini menggunakan pendekatan kuantitatif dengan desain eksperimental dengan rancangan one group pretes dan posttest. Kelompok yang diteliti adalah pasien hemiparese poststroke yang diberikan latihan stabilitas inti dengan metode ADIM.Hasil analisis menunjukkan bahwa terdapat pengaruh yang signifikan dari latihan stabilitas inti dengan metode ADIM terhadap peningkatan fungsi trunk dan aktivitas fungsional pada lansia pasca stroke. Temuan ini menunjukkan bahwa latihan stabilitas inti dapat menjadi intervensi yang efektif dalam program rehabilitasi untuk meningkatkan kualitas hidup lansia pasca stroke.
HUBUNGAN USIA DAN JENIS KELAMIN DENGAN ANGKA KEJADIAN PENYAKIT DIABETES MELITUS DI UPT PUSKESMAS STABAT
Authors: Susanti Nofi , Raniah Sofia , Agustin Annisa Marsya , Sari Nilam Cahya
Published: January 2025

Diabetes Melitus (DM) merupakan salah satu penyakit tidak menular yang prevalensinya terus meningkat di seluruh dunia, termasuk di Indonesia. Faktor usia dan jenis kelamin dianggap memiliki pengaruh signifikan terhadap risiko terjadinya DM. Penelitian ini bertujuan untuk menganalisis hubungan antara usia dan jenis kelamin dengan angka kejadian DM di UPT Puskesmas Stabat. Studi ini menggunakan desain cross-sectional dengan pendekatan kuantitatif. Data diperoleh dalam pengambilan sampel secara purposive sampling dengan total sebanyak 40 orang. Peneliti menggunakan teknik triangulasi data dengan membandingkan informasi yang diperoleh dari berbagai sumber (wawancara, observasi, dan dokumentasi). Selain itu, peneliti juga melakukan member checking dengan meminta partisipan untuk memverifikasi hasil wawancara dan interpretasi data yang dilakukan oleh peneliti. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara usia dengan kejadian DM, bahwa mayoritas responden adalah perempuan (87,5%) dan berada pada rentang usia 55-80 tahun (57,5%). Semua responden yang diteliti memiliki Diabetes Melitus tipe II (100%). Sebagian besar responden bekerja sebagai Ibu Rumah Tangga (80%). Berdasarkan penelitian yang dilakukan, ditemukan bahwa usia dan jenis kelamin memiliki hubungan yang signifikan dengan angka kejadian Diabetes Melitus (DM) di UPT Puskesmas Stabat. Usia yang lebih tua, terutama di atas 45 tahun, secara konsisten dikaitkan dengan peningkatan risiko terkena DM. Hal ini disebabkan oleh perubahan fisiologis yang terjadi seiring bertambahnya usia, seperti penurunan sensitivitas insulin dan penurunan fungsi pankreas
AIRWAY AND ANESTHETIC MANAGEMENT IN ROBINOW SYNDROME PATIENT WITH SEVERE AORTIC STENOSIS FOR DENTAL SURGERY : A CASE REPORT
Authors: Cahyono Ardy Wibowo , Pradhana Adinda Putra , Senapathi Tjokorda Gde Agung
Published: January 2025

Robinow Syndrome (RS) adalah kelainan genetik langka yang ditandai dengan fitur kraniofasial dan abnormalitas skeletal yang khas, sering disertai dengan kelainan jantung, yang mempersulit manajemen anestesi. Pasien dengan RS sering mengalami tantangan signifikan dalam manajemen jalan napas karena karakteristik wajah dan skeletal, yang membuat manajemen jalan napas menjadi kompleks. Anomali vertebral juga mempersulit pemberian anestesi neuraksial, dan pemilihan agen induksi harus mempertimbangkan risiko jantung. Laporan ini membahas manajemen jalan napas dan anestesi yang berhasil pada seorang pasien RS berusia 13 tahun yang menjalani ekstraksi gigi akibat kerusakan gigi parah dan stenosis aorta. Pemeriksaan fisik pasien menunjukkan Mallampati IV dan Cormack-Lehane IV pada jalan napas, sehingga diperlukan teknik intubasi khusus seperti penggunaan gum elastic bougie untuk akses jalan napas yang berhasil. Fitur kraniofasial dan skeletal yang terkait dengan RS menimbulkan tantangan dalam manajemen perioperatif, sering kali membutuhkan pembedahan. Intubasi yang efektif pada pasien RS membutuhkan evaluasi praoperatif yang cermat, terutama pada kasus dengan micrognathia dan asimetri wajah. Evaluasi praoperatif yang komprehensif, termasuk penilaian fungsi jantung, ginjal, dan pernapasan, sangat penting untuk mengurangi komplikasi dan meningkatkan hasil. Manajemen anestesi harus memperhitungkan kesulitan jalan napas dan masalah jantung yang unik pada RS, dengan kesiapan menghadapi potensi tantangan intraoperatif. Kasus ini menyoroti pentingnya perencanaan yang teliti dan teknik khusus dalam mengelola anestesi pada pasien RS, khususnya mereka dengan kondisi jantung yang mempersulit