bluuebunny/crossref_metadata_2025 huggingface dataset:
Managing the global commons
Authors: Wijkman Per Magnus
Published: May 2009

When should internationally shared resources be subdivided and property and management rights to parts of the resource be distributed among nation states? Subdivision leads to inefficient exploitation and to an arbitrary division of benefits under three conditions: when property rights cannot be economically enforced; when the size and the value of the resource are unknown; and when exploitation involves external economies. The efficient use of such common property resources requires private or public regulation. Voluntary private regulation is likely to be effective only when few users are involved. In other cases, public regulation is called for. Some attributes of an intergovernmental organization designed to achieve efficient, equitable, and stable exploitation are presented. Current proposals for managing ocean resources, the orbit-spectrum resource, and Antarctica are considered.
Tariff protection in developed and developing countries: a cross-sectional and longitudinal analysis
Authors: Conybeare John A. C.
Published: May 2009

Four political models (the international system, rational domestic economic policy, intragovemmental politics, and interest group influence) may explain the cross-national structure of average nominal levels of tariffs on manufactures. Using available data measuring or approximating the explanatory variables for the time periods 1902 and 1971, selected hypotheses were tested in regression equations. The 1971 tariff levels are best predicted by rational economic policy variables while for 1902, international power variables provide the best predictions of the tariff. In general, the causal forces influencing the cross-national pattern of tariff levels appear to have shifted in the 20th century from those indicating international power to those measuring domestic politico-economic development. These results provide evidence relevant to some of the general propositions about size and development suggested by the contemporary political economy literature. They also lend support to those who argue that a rising level of international interdependence has resulted in long-term changes in the pattern of influences on national public policies.
Bridging the gap: international organizations as organizations
Authors: Ness Gayl D. , Brechin Steven R.
Published: May 2009

This article attempts to build a bridge between the study of international organizations and the sociology of organizations. Comparisons between functionalism in the two fields are found to be especially important in understanding different treatments of international organizations. We suggest that a number of concepts from the sociology of organizations can be effectively used to illuminate issues in international organizations. We focus on organizational performance and its determinants in environment, technology, goals, and structure. The authors' current work in international population planning and social forestry shows how the sociological concepts can offer useful perspectives and hypotheses for the study of international organizations.
Third World solidarity: the Group of 77 in the UN General Assembly
Authors: Iida Keisuke
Published: May 2009

The voting behavior of the Third World states in the United Nations shows that the Third World unity increased in the 1980s. Systemic theory reveals that changes in the power of the Third World could partly account for the increased unity. For a more complete explanation, I examine three models of the Group of 77—the communityof- interest model, the leadership model, and the reciprocal coordination model—and find that the data support the reciprocal coordination model most consistently.
The abolition of slavery and the end of international war
Authors: Ray James Lee
Published: May 2009

Slavery and war have both historically been considered inevitable consequences of human nature. Yet slavery has been abolished, and moral progress may have contributed to slavery's disappearance. Both realists and Marxists are skeptical about the impact of ethical constraints on political decisions, while idealists as well as at least some regime analysts emphasize the role of those constraints. However, elements of all of these approaches support the proposition that moral progress may bring an end to international war.

Some historical trends do not support the idea that international war is on the verge of disappearance, but there has not been a war between major powers since 1945. In addition, norms against colonialism are strong. No war has occurred between democratic states, nor does a war appear likely among the rather sizable number of industrialized democratic states in the international system today. Explanations of these pockets of peace based on caution induced by nuclear weapons or on economic interdependence, for example, are certainly not beyond question. Therefore, it may be that norms inhibiting the initiation of international war have already made obsolete not only wars between the richest and most powerful states in the world but also some forms of depradation by the strong against the relatively weak states.
What's at stake in the agent-structure debate?
Authors: Dessler David
Published: May 2009

Recent developments in the philosophy of science, particularly those falling under the rubric of “scientific realism,” have earned growing recognition among theorists of international relations but have failed to generate substantive programs of research. Consequently, the empirical relevance of much philosophical discourse, such as that centering on the agent-structure problem in social theory, remains unestablished. This article attempts to bridge the gap between the philosophy and practice of science by outlining a model of international structure based on the principles of scientific realism and by considering its implications for a structural research program in international relations theory. Appealing to Imre Lakatos's methodology of theorychoice, the article presents an ontological case for adopting a “transformational” model of structure over the “positional” model developed in the work of Kenneth Waltz. The article demonstrates that the positional approach offers no conceptual or explanatory hold on those features of the international structure that are the intended products of state action. In conclusion, the article argues that the stakes in the agent-structure debate include the capacity to generate integrative structural theory and the ability to theorize the possibilities for peaceful change in the international system.
Subject and system in international interaction
Authors: Dryzek John S. , Clark Margaret L. , McKenzie Garry
Published: May 2009

Recent interest in cognitive approaches to international interaction in general and international regimes in particular has not been matched by development in theory and methodology. This article details a systematic “subjective” approach that seeks to meet this need. Its claims are developed through its comparison with the accomplishments and shortcomings of more established approaches to the study of international interaction and, in particular, microeconomic formal theory. The subjective alternative can model both individual subjects and the systems in which they are participating. As such, it offers much more in terms of continuities and connections between agents and system structure than do traditional psychological analyses in international relations. The theoretical arguments proceed in the context of a study of cooperation and conflict over Antarctica and its evolving regimes.
International economic structures, government interests, and international coordination of macroeconomic adjustment policies
Authors: Webb Michael C.
Published: May 2009

Analysts have commonly argued that there has been a decline in international coordination of the kinds of policies that governments can use to manage the international payments imbalances that emerge when different governments pursue different macroeconomic policies. The decline typically has been attributed to a posited decline in American hegemony. In contrast, this article argues that international coordination of macroeconomic adjustment policies (trade and capital controls, exchange rate policies, balance-of-payments financing, and monetary and fiscal policies) was at least as extensive for much of the 1980s as it had been in the 1960s. There was, however, a shift away from coordination of balance-of-payments financing and other policies that have limited direct consequences for domestic economic and political conditions and a concurrent shift toward coordination of monetary and fiscal policies that are critically important for domestic politics and economics. This change is best explained as a consequence of changes in the structure of the international economy. Most important, international capital market integration encouraged governments to coordinate monetary and fiscal policies because balance-of-payments financing and exchange rate coordination alone are insufficient to manage the enormous payments imbalances that emerge when capital is able to flow internationally in search of higher interest rates and appreciating currencies.
Industrial governance structures, innovation strategies, and the case of Japan: sectoral or cross-national comparative analysis?
Authors: Kitschelt Herbert
Published: May 2009

In comparative research on industrial policy strategies, attention has shifted from national-level variables to sectoral variables in both the description and the explanation of policy. The sectoral literature, however, lacks analytic focus and has provided little systematic insight into the causes of cross-sectoral variance in governance structures and policy strategies. Based on recent contributions to the economics and sociology of formal organizations, this article attempts to sharpen the concept of “industrial sector” and to provide a rationale for why sectoral structures and strategies vary. Next, it develops a synthetic explanatory framework that combines sectoral analysis and national domestic structuralism in order to account for industrial innovation strategies in advanced capitalist countries. In the final section, the fruitfulness of this approach is illustrated by developing a new account of Japan's success and failure in industrial innovation, an account that overcomes the contradictions among the main alternatives offered in the past. The key objective of the article, however, is to develop a new set of theoretical hypotheses for cross-national research, not a rigorous empirical test of its main propositions.
Political responses to interdependence: what's “left” for the left?
Authors: Garrett Geoffrey , Lange Peter
Published: May 2009

Heightened economic interdependence in recent years is commonly argued to have generated great pressures for convergence in economic policies across the advanced industrial democracies. Interdependence has clearly had a great impact on the types of economic policies that governments can pursue: they have been unable to pursue independent fiscal and monetary policies since the mid-1970s. Furthermore, all governments have been forced to attempt to promote the competitiveness of national goods and services in world markets and to increase the speed and efficiency with which national producers adjust to changes in global markets. There are, however, different policies consistent with these goals. Statistical analyses of economic policies since the mid-1970s show that governments of the left and the right continue to be able to enact distinctive supply-side policies that promote competitiveness and flexible adjustment and simultaneously further their partisan objectives.
International regimes and alliance behavior: explaining NATO conventional force levels
Authors: Duffield John S.
Published: May 2009

With the end of the cold war, the military posture of the North Atlantic Treaty Organization (NATO) has entered a period of profound change. Prior to the recent dramatic political events in Europe, however, NATO conventional force levels in the Central Region had been remarkably stable for some three decades. This article seeks to explain this record of stability in terms of three widely used theories of international relations. It argues that balance-of-power theory and public goods theory cannot alone provide a satisfactory account. Rather, these traditional approaches for understanding alliance behavior must be supplemented by regime theory, which emphasizes the constraining effects of enduring institutional factors even in the face of structural change. Specifically, it shows how an international regime has influenced the provision of conventional forces in the Central Region by alliance members. More generally, this analysis seeks to contribute to the literature on international regimes in three ways. First, it demonstrates that regimesdomatter by providing an example of their importance for explaining state behavior and international outcomes. Second, it extends regime theory to relations among military allies. Third, it elaborates a comprehensive model for understanding why states actually comply with regime injunctions. The model stresses both the ways in which regimes effectively modify the international environment within which states operate, altering the costs and benefits associated with different courses of action, and the ways in which participating states may internalize regime norms and rules, thereby making compliance increasingly automatic.
Inertia and change in the constellation of international governmental organizations, 1981–1992
Authors: Shanks Cheryl , Jacobson Harold K. , Kaplan Jeffrey H.
Published: May 2009

Hardly anyone expects public institutions to die. Yet a census reveals that fully one-third of the international governmental organizations (IGOs) in existence in 1981 had in fact become defunct by 1992. Most Eastern bloc and many regional developing country organizations vanished or became inactive. During this period a slightly larger number of new organizations was born. Not governments but other IGOs spawned most of the new offspring. Wealthy democratic countries increased their IGO memberships while poor unstable countries increasingly dropped out. This bifurcation was accompanied by greater reliance by all on a set of core universal-membership institutions dominated by Western values. Functionalism, organizational ecology, and realism each partly help us to understand these trends but leave important dynamics unexplained.
Third-party techniques for preventing conflict escalation and promoting peaceful settlement
Authors: Dixon William J.
Published: May 2009

Although agents employ a wide range of conflict management techniques in practice, scholars have evaluated only a few of these. A more complete empirical analysis of the spectrum of third-party procedures used to manage international crises reveals that two techniques in particular are most effective: mediation efforts and third-party activities to open or maintain lines of communication. The endpoints of preventing escalation and promoting peaceful settlement take into account the notion of conflict as a dynamic evolutionary process, consisting of several phases, which in turn affect the outcome of third-party management. Crisis management methods that have proved successful in a bipolar world may be similarly successful in the post-cold war environment, an issue future work must address.
United Nations Peace Forces and the Changing United Nations: An Institutional Perspective
Authors: Urquhart Brian E.
Published: May 2009

At its founding one of the UN's most publicized advantages over its predecessor, the League of Nations, was the fact that it was a peace organization “with teeth.” This somewhat unattractive phrase referred to Chapter VII of the Charter and the possibility of military force being put at the disposal of the Security Council. In fact this provision of the Charter was one of the first victims of East-West disagreement, and, although the Military Staff Committee met regularly for many years and in the early years held voluminous discussions, the actual military arrangements foreseen in Chapter VII never became a reality. The assumption of the continuing unanimity of the great powers, which particularly affected this part of the Charter, proved to be illusory almost at once, while the idea that the Organization could not and should not take collective action against one of the great powers has continued, with the partial exception of Korea, to be respected. Thus it has become increasingly clear that the United Nations can neither deal with an aggression arising from a great-power conflict nor use the military resources of the great powers directly in dealing with other breaches of the peace, since such a use might all too easily project the great-power struggle onto the situation being dealt with. The development of new forms of peace-keeping machinery have in part been the response of the Organization to this dilemma.
International Force in a Disarming—but Revolutionary—World
Authors: Bloomfield Lincoln P.
Published: May 2009

General disarmament plans, like weapons of mass destruction, supply excessive solutions to problems, and, like those weapons, they tend to leave unanswered many highly pertinent questions about lesser conflicts, low-level disorders, ambiguous enemies, and local policing jobs. By and large, strategic planners have come to recognize this weakness in military doctrines, but it is not certain that the planners of general and complete disarmament (GCD) yet recognize that a blueprint geared to the deliberate violation, the great war, the two super-states in hostile confrontation, may turn out to be quite irrelevant to the real problems of a disarmed or even semidisarmed world. At best such a blueprint is bound to be deficient until it comes to grips with disorders other than classic open encounters of two states—that is, with the painfully familiar gamut ranging from civil war fomented in a great state by outside agents to the purely internal breakdown of law and order in a small state.
Changing relations among the government, labor, and business in Japan after the oil crisis
Authors: Kume Ikuo
Published: May 2009

Many scholars argue that labor is excluded from Japan's political system. However, since the 1970s, labor has become considerably influential in the policymaking process in Japan. The oil crisis of 1973 and theShuntouwage bargaining of 1975 have made labor, especially private-sector unions, modest in their wage demands, but at the same time these events have made labor participate actively in the policymaking process in order to maintain employment and seek some benefits from the government. This article demonstrates that Japan's increasing export-dependence and tradeoffs between wage increases on the one hand, and inflation and unemployment on the other in the 1970s, have driven labor to this new, more active role in policymaking, while the necessity for the governing Liberal Democratic party to seek a new constituency has enabled labor to achieve some success in this new role. This implies that Japan's political system has changed its nature since the 1970s; its political process has become more pluralistic with labor's participation within the existing political system.
The GATT and the regulation of trade barrier: regime dynamics and functions
Authors: Finalyzson Jock A. , Zacher Mark W.
Published: May 2009

Since the Second World War complex and changing sets of norms and rules have governed trade relations among most countries. They have largely originated from a unique and accidental international organization, the General Agreement on Tariffs and Trade (GATT). We have labeled these norms, rules, and decision-making mechanisms the GATT regime or global trade barriers regime. The importance that GATT members have attached to certain norms has shaped the regime's procedural mechanisms, rules, and implementation of rules. Classifying those norms as sovereignty or interdependence norms, we posit that the strength or autonomy of the regime can be established by analyzing the prominence of the interdependence norms in the issue area. We close by exploring some of the functions of the regime in international trade and political relations.
The international organization of Third World debt
Authors: Lipson Charles
Published: May 2009

Third World debt grew very rapidly in the 1970s. Many states, faced with sharply higher costs for energy and manufactured imports, borrowed aggressively in unregulated offshore capital markets. But what constrains sovereign states to repay this debt to commercial banks? Creditors do not turn to their home states to enforce payment; rather, the supervision of sovereign debt is largely a function of commercial banking arrangements, especially lenders' syndicates, and the International Monetary Fund's conditional lending. This political structure, which involves unified private sanctions, has ensured that no state defaults unless it is insolvent or is willing to accept a radical rupture in its international commercial relationships. When the problem is insolvency, creditors routinely convene ad hoc conferences. In conjunction with an IMFapproved stabilization program, creditors can renegotiate debt-service schedules and provide new financing if necessary. These arrangements are distinctive among international economic regimes because they rely on nonstate actors as the primary source of rules, norms, and procedures.
The creation and matintenance of national boundaries in Africa
Authors: Herbst Jeffrey
Published: May 2009

A paradox is central to the nature of political boundaries in Africa: there is widespread agreement that the boundaries are arbitrary, yet the vast majority of them have remained virtually untouched since the late 1800s, when they were first demarcated. This article argues that, contrary to current theories, the present boundary system represents a rational response by both the colonialists and the present-day African leaders to the constraints imposed by the demographic and ethnographic structure of the continent. Using this framework of analysis, the article examines the institutions that formulated the decision-making rules for the creation and maintenance of boundaries in Africa, discusses the conditions under which cooperation among states has occurred, and explores the prospects for future changes in the borders of African states.
France and Germany in the Atlantic Community
Authors: Grosser Alfred
Published: May 2009

The North Atlantic Treaty has been in existence since April 4, 1949. Article 9 of this treaty gave birth to the North Atlantic Treaty Organization, and the imposing headquarters on the edge of the Bois de Boulogne in Paris bear witness to its reality. In his chapter dealing with the nature of the Community, Stanley Hoffmann discusses the question of whether a true Atlantic Community exists outside the pages of the treaty. The present study will examine the existence of that Community insofar as two of its principal members are concerned: France and the Federal Republic of Germany.
The European Neutrals and the Atlantic Community
Authors: Freymond Jacques
Published: May 2009

When major plans for European or Atlantic integration are under discussion, European neutrals receive little attention. Much concern is expressed over the impact of the European Economic Community or of an Atlantic Community upon Latin America, Africa, or Asia, and considerable care is exercised to alleviate apprehension, to quiet fears, to subdue sharp reactions, and, finally, to prevent retaliatory action. But the situation of the small neutral European states is only mentioned in passing. In the last analysis, more consideration is shown for distant and often hostile neutralists than for neutral, but friendly, neighbors.
Building a Political Community
Authors: Haviland H. Field
Published: May 2009

These reflections on the centrifugal tendencies of interstate associations and the need for a stronger central union were penned 175 years ago by Alexander Hamilton, but they could easily have been taken, save for the quaint language, from the current debate on the Atlantic Community. As Hamilton pondered the problem of strengthening the integrating sinews of the new nation, so modern Hamiltons voice similar thoughts concerning the possibility of creating a stronger Atlantic political community.
The Future of the Atlantic Community
Authors: Norstad Lauris
Published: May 2009

I fully share the conviction expressed by President Kennedy in May 1962 that “Atlantic unity represents the true course of history.” This seems to me inevitable despite the complications, contradictions, and conflicts of national policies which are still very much with us.
Economic liberation and regional cooperation in Southern Africa: SADCC and PTA
Authors: Anglin Douglas G.
Published: May 2009

Two of the most significant regional organizations to emerge in Southern Africa in recent years are the Southern African Development Coordination Conference (SADCC), with nine members, and the Preferential Trade Area for Eastern and Southern Africa (PTA), comprised of fourteen states including five SADCC members. Although their purposes and programs are similar and steadily converging, SADCC and PTA exhibit distinct differences in their origins, memberships, institutional structures, financial patrons, ideologies, and strategies. Although national development remains the ultimate aim of both bodies, reducing external dependency, especially in the case of SADCC on South Africa, and regional cooperation are seen as essential to success. While obvious areas of conflict exist, the two organizations may be able to restrain their rivalry in the interests of their members and possibly of their own survival.
Chain gangs and passed bucks: predicting alliance patterns in multipolarity
Authors: Christensen Thomas J. , Snyder Jack
Published: May 2009

Contemporary balance-of-power theory has become too parsimonious to yield determinate predictions about state alliance strategies in multipolarity. Kenneth Waltz's theory predicts only that multipolarity predisposes states to either of two opposite errors, which this article characterizes as chain-ganging and buck-passing. To predict which of these two policies will prevail, it is necessary to complicate Waltz's theory by adding a variable from Robert Jervis's theory of the security dilemma: the variable of whether offense or defense is perceived to have the advantage. At least under the checkerboard geographical conditions in Europe before World Wars I and II, perceived offensive advantage bred unconditional alliances, whereas perceived defensive advantage bred free riding on the balancing efforts of others.
Long waves, technological innovation, and relative decline
Authors: Thompson William R.
Published: May 2009

The popularity of Kondratieff long waves fluctuates according to the economic climate. Periods of slow growth help make long wave explanations more attractive. While their popularity may oscillate, the evidence associated with the existence of long waves continues to be disputed. A review of the pertinent theoretical literature suggests that one reason for the disagreements about the existence of long waves is that much of the available evidence does not correspond as closely as it might to the theoretical foci. A new data series, one based on leading sector production growth rates from 1760 to 1985, is developed to remedy this lack of correspondence. The appropriate analysis of this series requires that particular attention be paid to the rise and relative decline of the world economy's lead state. The empirical outcome provides a close match to the long wave chronology developed by Joseph Schumpeter, Simon Kuznets, and J. J. Van Duijn. While this approach falls short of bringing closure to many of the theoretical and empirical questions concerning long waves, it does establish a solid empirical foundation for further analyses. The article concludes with some observations on the long wave implications for the relative economic decline of Britain in the nineteenth century and the United States in the twentieth century.
Taxation and the political economy of the tariff
Authors: Hansen John Mark
Published: May 2009

Traditional accounts of U.S. tariff policy emphasize trade strategies and interest group politics. This article makes a departure. It opens with an observation: up until World War I, the tariff was the largest single source of federal government revenues. It then explores the significance of tariffs as taxes, theoretically and empirically.

In its first part, the article develops a theory of taxation politics and applies it to the tariff. In its second part, it submits the theory to an empirical test, modeling changes in U.S. tariff rates from 1829 to 1940. The politics of tariff revision, it argues, followed from two characteristics of the tariff as tax: from the extent of the treasury's dependence upon it and from the distributive pattern of its burdens and benefits. Taken together, the article concludes, revenue dependence and distributive incidence account for several diverse aspects of American tariff policy, including the structure of its coalitions, the shifts in its objectives, and the timing of its innovations.
The occurrence of Angiostrongylus vasorum in terrestrial slugs from forests and parks in the Copenhagen area, Denmark
Authors: Ferdushy T. , Kapel C.M.O. , Webster P. , Al-Sabi M.N.S. , Grønvold J.
Published: May 2009

A total of 298 slugs belonging to four species, Arion lusitanicus, A. ater, A. ater rufus and Limax maximus, were collected from six different localities within a radius of 30 km from Copenhagen and examined for naturally acquired Angiostrongylus vasorum infection. Overall, 28 slugs (9%) were infected, but the prevalence varied among the studied localities: Rude Forest (26%), West Amager Forest (18%), Jaegersborg Forest and Deer Park (8%), Frederiksberg Park (4%), Assistens Cemetery Park (0%) and Frederiksberg Botanical Garden (0%). Only third-stage larvae (L3) were recovered from the slugs, in numbers ranging from 1 to 392 per slug. Overall 82% of the infected slugs harboured fewer than 10 larvae and only 14% harboured over 100 larvae.
Local immune status and tumour marker expression in the human larynx
Authors: Nakashima T , Tomita H , Chitose S , Umeno H , Sato K
Published: May 2009

This study examined the local immune status and tumour marker expression in secretions and related tissue specimens from the laryngeal ventricle, comparing individuals with and without head and neck cancer. Laryngeal secretion and mucosal tissue specimens were collected during laryngeal microsurgery or surgical laryngectomy. The laryngeal secretions were found to contain immunological factors such as immunoglobulins G and A and secretory immunoglobulin A. A high level of the tumour marker Cyfra 21-1 was also detected in laryngeal secretions and mucosal tissue. Lows levels of secretory immunoglobulin A and Cyfra 21-1 were seen in the laryngeal mucosal tissue of controls and patients who had previously undergone radiation therapy. The level of secretory immunoglobulin A in laryngeal secretions closely correlated to the level of this immunoglobulin in mucosal tissue. These results indicate that local immunity is present in the human larynx; furthermore, it is strongly affected both by the presence of malignancy and by laryngeal cancer treatments such as irradiation.
Expression of dendritic cell phenotypic antigens in cervical lymph nodes of patients with hypopharyngeal and laryngeal carcinoma
Authors: Li X , Takahashi Y , Sakamoto K , Nakashima T
Published: May 2009

Background:

The purpose of this study was to assess the presence of dendritic cell phenotypic antigens in the cervical lymph nodes of patients with hypopharyngeal and laryngeal carcinoma, and to assess the significance of such antigens in the tumour immune reaction.

Methods:

Immunohistochemical staining of cervical lymph nodes was performed using antibodies against cell surface markers such as S-100 protein and cluster of differentiation 1a and 83 glycoproteins. Two hundred and seventy-four cervical lymph nodes obtained at surgery from 37 patients with hypopharyngeal carcinoma and 31 patients with laryngeal carcinoma were thus evaluated.

Results:

The number of dendritic cells positive for each phenotypic antigen was significantly greater in non-metastatic lymph nodes than in metastatic lymph nodes. In the metastatic lymph nodes, cluster of differentiation 1a glycoprotein positive dendritic cells were predominantly detected in the cancer ‘nest’, whereas mature dendritic cells staining for cluster of differentiation 83 glycoprotein were prominent in the peritumour area. In the metastatic lymph nodes, in contrast to the cluster of differentiation 1a glycoprotein positive dendritic cells, the degree of infiltration of cluster of differentiation 83 glycoprotein positive dendritic cells was significantly higher in the peritumour area than in the cancer nest. There was a significant difference in survival status, comparing patients with different degrees of dendritic cell infiltration for each type of phenotypic antigen.

Conclusions:

Dendritic cells may play different roles in tumour immunity against hypopharyngeal and laryngeal carcinoma. The phenotypic antigens of dendritic cells may thus constitute important indices with which to predict the prognosis of patients with hypopharyngeal and laryngeal carcinoma.
Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma
Authors: Li X , Sakamoto K , Takahashi Y , Nakashima T
Published: May 2009

Objective:

This study aimed to determine the expression of the Cap43 gene in supraglottic laryngeal squamous cell carcinoma, and to evaluate any correlation between Cap43 gene expression and tumour-associated macrophage infiltration.

Methods:

Four human head and neck squamous cell carcinoma cell lines were cultured (Hep2, KB, Ca9-22 and HSC-3) and expression of the Cap43 gene was analysed by Western blotting. In addition, paraffin-embedded samples of supraglottic laryngeal squamous cell carcinoma and normal supraglottic laryngeal mucosa from 84 patients were analysed immunohistochemically using antibodies to Cap43 and cluster of differentiation 68 glycoprotein. Patients' clinical status was compared with their immunohistochemical results.

Results:

All four head and neck squamous cell carcinoma cell lines exhibited Cap43 expression. The Hep2, Ca9-22 and HSC-3 cells showed a markedly higher level of Cap43 protein than the KB cells. A statistically significant difference was found in Cap43 expression, comparing different differentiation levels and comparing different metastasis stages, for supraglottic squamous cell carcinoma. The number of tumour-associated macrophages correlated with expression of Cap43, not only in the tumour area (r = 0.3708, p = 0.0005) but also in the peritumour area (r = 0.2847, p = 0.0087).

Conclusion:

In supraglottic laryngeal squamous cell carcinoma, overexpression of the Cap43 gene is associated with tumour differentiation and acts an important suppressive factor in the process of tumour metastasis. The Cap43 gene may be a cancer-specific marker. High expression of the Cap43 gene appeared to correlate with infiltration of tumour-associated macrophages.
Repair with sternohyoid muscle fascia after subtotal laryngectomy
Authors: Dong P , Li X , Wang G , Chen X , Xie J , Nakashima T
Published: May 2009

Background:

The subtotal laryngectomy procedure enables the patient to avoid some of the serious consequences of total laryngectomy without having to relinquish oncological effectiveness. However, the important complication of aspiration may still seriously affect some patients. Many methods of reconstruction have been described in an attempt to avoid or minimise this complication.

Methods:

Thirty-nine patients (15 with supraglottic laryngeal cancer and 24 with hypopharyngeal cancer) who had undergone subtotal laryngectomy between 2000 and 2006 were included in this study. In all patients, a sternohyoid muscle flap has been used for primary, one-stage reconstruction of laryngopharyngeal defects, following resection of advanced stage lesions. Patients' times to oral intake and decannulation, their speech function and their post-operative complications were reviewed.

Results:

The patients' three-year overall survival rate was 46.1 per cent. Their mean time to oral intake was 14 days. Twenty-six patients were decannulated (66.7 per cent). Almost all patients regained their speech function post-operatively, although their voice quality was not as good as before surgery.

Conclusions:

Sternohyoid muscle fascia reconstruction leads to optimal repair of subtotal laryngectomy defects and restored laryngeal function.
Histopathological study of correlation between laryngeal space invasion and lymph node metastasis in glottic carcinoma
Authors: Chijiwa H , Sato K , Umeno H , Nakashima T
Published: May 2009

Objectives:

The paraglottic space and cricoid area of the larynx are made up of loose, areolar tissue composed of loose elastic and collagenous fibres and adipose tissue. They contain the main blood vessels of the larynx. We examined the correlation between the histopathological extension of glottic carcinoma into the paraglottic space or cricoid area and the development of cervical lymph node metastasis.

Study design:

We reviewed the medical charts of 45 patients (44 men and one woman) who had undergone total laryngectomy for squamous cell carcinoma of the glottis between 1991 and 2003.

Methods:

Macroscopic and microscopic study of the removed larynges of the same patients was performed, and the histopathological evidence for invasion of the paraglottic space or cricoid area was analysed.

Results:

Eight of the 24 patients (33 per cent) with invasion of the paraglottic space or cricoid area had cervical lymph node metastasis. In contrast, only one of the 21 patients (5 per cent) without any evidence of invasion of either space had lymph node metastasis. This difference was statistically significant (p < 0.05). In the 36 patients free of cervical lymph node metastasis, recurrence in the neck occurred in six (38 per cent) of the 16 patients with paraglottic space or cricoid area invasion, but in only one (5 per cent) of the 20 patients without paraglottic space or cricoid area invasion (p < 0.05).

Conclusion:

In patients with glottic carcinoma, invasion of cancer into the paraglottic space or cricoid area is an important prognostic factor for the development of cervical lymph node metastasis.
Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours
Authors: Sakamoto K , Ono T , Nakamura Y , Harada H , Nakashima T
Published: May 2009

Objectives:

This study aimed to clarify the significance of cluster of differentiation 9 glycoprotein gene expression in human parotid gland tumours.

Methods:

We retrospectively analysed immunohistochemical staining for cluster of differentiation 9 glycoprotein in parotid gland tumours.

Results:

Cluster of differentiation 9 glycoprotein was consistently detected in the normal parotid gland. Regarding benign parotid gland tumours, cluster of differentiation 9 glycoprotein was present in 13 of 18 pleomorphic adenomas, in all Warthin tumours tested (21/21) and in all cases of basal cell adenoma tested (four of four). In contrast, positive staining for cluster of differentiation 9 glycoprotein was less often observed in malignant parotid tumours. Cluster of differentiation 9 glycoprotein was present in 11 of 14 mucoepidermoid carcinomas, in two of five acinic cell carcinomas and in two of five adenoid cystic carcinomas.

Conclusions:

There was a statistically significantly reduced expression of cluster of differentiation 9 glycoprotein in malignant parotid gland tumours, compared with benign parotid gland tumours (p < 0.05). These results suggest that a low level of cluster of differentiation 9 glycoprotein expression in parotid gland tumours may be associated with malignancy.
Analysis of surgical treatment for middle-ear cholesterol granuloma
Authors: Matsuda Y , Kurita T , Ueda Y , Ito S , Nakashima T
Published: May 2009

Cholesterol granuloma is an intractable ear disease. Many studies of this condition have been published since the initial report by Manasse. However, the pathogenesis of this condition is unclear. This study reviewed the treatment of middle-ear cholesterol granuloma in 16 patients undergoing surgical treatment at Kurume University Hospital.

The relationship between patients' pre-operative tympanic membrane findings and post-operative course was analysed. Patients with swollen tympanic membranes had significantly poorer outcomes. Patients with retracted tympanic membranes and those undergoing ossicular chain reconstruction had significantly better outcomes. The patients' overall hearing success rate at approximately two weeks post-operatively was 75 per cent. However, by six months post-operatively, the overall hearing success rate had declined to 62.5 per cent. Patients with poor hearing two weeks post-operatively did not acquire better hearing.
New silicone tube placement therapy for patients with an anterior glottic web
Authors: Umeno H , Chitose S , Ueda Y , Kurita T , Mihashi H , Nakashima T
Published: May 2009

An anterior glottic web in adults comprises a bridge of scar tissue commonly formed as a result of iatrogenic laryngeal injury. Traditionally, procedures such as transcervical midline thyrotomy and keel placement have been used to repair this condition. However, we recently repaired an anterior glottic web using a new surgical procedure involving a silicone tube instead of a keel. We herein report this case, in which we placed a silicone tube at the anterior commissure after resection of an anterior glottic web, under endolaryngeal microsurgery, without performing a tracheostomy.
Clinical study of parapharyngeal space tumours
Authors: Chijiwa H , Mihoki T , Shin B , Sakamoto K , Umeno H , Nakashima T
Published: May 2009

This study reviewed 24 cases of parapharyngeal space tumour treated at Kurume University Hospital between 1990 and 2007. Histological diagnoses were generally obtained from the excised tumour (22/24). Seventy-seven per cent of the parapharyngeal space tumours were benign and 23 per cent were malignant. Thirty-eight per cent (eight of 22) of these tumours were pleomorphic adenomas and 23 per cent (five of 22) were schwannomas. A transparotidectomy and transcervical approach were used in 88 per cent (15/17) of benign tumours. A mandibular swing approach was used for one malignant tumour. Post-operative complications were identified in 16 of 22 patients. The most common complication, facial nerve paralysis, was identified in eight patients, and seven of these patients demonstrated first bite syndrome. In consideration of the high incidence of post-operative complications, the surgical approach should therefore be carefully selected when treating patients with parapharyngeal space tumours.
Cricopharyngeal dysfunction with significant piriform sinus expansion: case report
Authors: Chitose S , Umeno H , Hamakawa S , Gondou K , Nakashima T
Published: May 2009

This report describes the case of a patient with cricopharyngeal dysfunction with significant piriform sinus expansion. An 80-year-old man presented with a three-year history of dysphagia. Palsy of the cricopharyngeal chalasis was identified by electromyography under both videofluorography and manofluorography. Although a widening procedure was performed in the cricopharyngeal region using a bougie, the patient gained only minor relief from his dysphagia. After the patient had had adequate time to recover spontaneously (six months), a cricopharyngeal myotomy was performed. As a result, his dysphagia resolved and the post-operative course was uneventful. The clinical and histopathological findings in this case suggested that significant piriform sinus expansion had resulted from the cricopharyngeal dysfunction, due to cricopharyngeal myopathy.
Review of research on language teaching, learning and policy published in 2007
Authors: Johnstone Richard
Published: May 2009

My research review of 2007 is somewhat shorter than in earlier years in order to allow space for the journal's impressively increased number of other articles. This naturally adds to my problems of selection, especially as 2007 witnessed the welcome appearance of new international journals in the form of Innovation in Language Learning & Teaching and a considerably re-vamped Language Learning Journal. Accordingly, my selection of articles is not intended as a representative sample of the Applied Linguistics field but should be taken as a personal judgement based on attempting an appropriate range of the following: journals, languages, topics, countries, institutional settings, levels of proficiency, learner age, theory, practice, and personal interest. My selection is organised under a number of headings, but these offer only a general clue as to what a particular article is about, since most articles reviewed have reverberations across a number of headings rather than one alone. In addition, what I say about a particular article is not meant to be a summary. Those wishing to see a summary should go to the article itself and read its abstract. My account of a particular article may in fact reflect only one theme within the article which I have chosen to highlight.
Review of doctoral research in second-language teaching and learning in England (2006)
Authors: Marsden Emma , Graham Suzanne
Published: May 2009

Using the British ‘Index to Theses’, we found forty-seven Ph.D.s relating to second and foreign language learning and/or teaching defended in English universities in 2006. Objective criteria led us to fourteen theses which had investigatedbothteaching and learning. Over half of these adopted a process–product research design with the aim of finding causal relationships between teaching and learning. Six theses focused on individual differences (motivation, strategies, attitudes), with three adopting an ‘effectiveness-of-intervention’ approach and three following more descriptive, exploratory designs. The designs of the ‘effectiveness-of-intervention’ studies varied greatly, ranging from naturalistic evaluations to highly controlled randomised control experiments. They covered a range of pedagogical concerns, including the use of computers, error correction, language portfolios, learner strategies and communicative-style activities. In addition to our own comments on the quality of the studies and reports, we present considerable methodological detail to enable the reader to evaluate the validity of the findings and claims made in each study. We argue that Ph.D. theses need to demonstrate fully that the implications drawn from the study are supported by the data collection and analyses described, which was not always the case in the theses reviewed. Finally, we make suggestions for future areas of investigation by postgraduate researchers.
Blend of independent joint control and variable structure systems for uni-drive modular robots
Authors: Karbasi Hamidreza , Huissoon Jan Paul , Khajepour Amir
Published: May 2009

In this paper, a control design methodology for a new class of modular robots, so-called “uni-drive modular robots” is introduced. Uni-drive modular robots have a substantial advantage over regular modular robots in terms of the mass of each module since then employ only a single drive for powering all the joints. The drive is mounted at the robot base and all joints tap power from this single drive using clutches. By controlling the engagement time of the clutches, the position and velocity of the joints are regulated. After reviewing the structure of the uni-drive modular robot, a self-expansion formula to generate the dynamics of the robot is introduced. The control of uni-drive n-module robots is realized by blending independent joint control and theory of variable structure systems via a pulse width modulation technique. A uni-drive modular robot is used to conduct simulations and validate the control design technique.