bluuebunny/crossref_metadata_2025 huggingface dataset:
INSERÇÃO DO GRADUANDO DE ENFERMAGEM NO PROGRAMA DE INCIAÇÃO CIENTÍFICA: ESTUDO DE REFLEXÃO
Authors: Silva Emanuelly Soares Barbosa da , Santo Michelly Cristina do Espírito , Constantino Gabriel Nivaldo Brito , Acioli Milena Maria da Silva , Pedrosa Pietro Henrique Benevides , Oliveira Ane Raquel de , Isaias Camila de Sousa Martins , Ribeiro Wanderson Alves
Published: May 2024

Introdução: O graduando de enfermagem necessita apoiar-se na formação da construção de conhecimento científico para garantir uma assistência adequada e qualificada para a população à qual assistirá. Objetivo: Este estudo tem o propósito de reunir informações para ajudar e fomentar a importância que a pesquisa científica poderá ter na vida do graduando após a sua formação.  Metodologia: Realizou-se uma revisão integrada da literatura, objetivando coletar e resumir o conhecimento científico já desenvolvido sobre esta temática para melhor compreendê-la. Análise e discussão dos resultados: A pesquisa demonstra que há uma importância significativa para incorporar o programa de iniciação científica nas universidades. Deste modo, ao agregar os programas de iniciação científica, o Brasil possibilitou a abertura para uma vivência no ensino, pesquisa e extensão. Portanto, transformando o aluno pesquisador mais crítico e técnico. A enfermagem segue demonstrando que obtém uma gama de produção científica, sendo uma das profissões que mais pesquisam. Conclusão: Por fim, destaca-se que o programa possibilita que seja criada uma nova perspectiva, forma de pensar, agir e abre um leque de possibilidades, melhores oportunidades profissionais, maior embasamento para a assistência dos profissionais que estão na linha de frente da saúde.
O ENFOQUE DO TRANSTORNO DO ESPECTRO AUTISTA (TEA) NO CONTEXTO EDUCACIONAL
Authors: Viudes Mateus Martins , Sousa André Cristovão , Momo Luan Felipe , Lima Simone Nogueira de , Bastos Sérgio Felipe Abreu de Britto , Fernandes Julia Maria Fernanda Machado , Gutierrez Giuliana Loffredo , Melo Camila de Souza , Nogatz Elizete Jankoski
Published: May 2024

A presente pesquisa teve como objetivo quantificar pesquisas brasileiras que discorrem a respeito do autismo e da educação. Diante do crescente interesse e reconhecimento das necessidades específicas de indivíduos no espectro do autismo, bem como da importância da educação inclusiva, esta análise busca lançar luz sobre o panorama atual da produção científica brasileira nesse domínio. A pesquisa foi realizada no SciELO, e encontrou 113 trabalhos, dos quais são apresentadas ponderações à luz de suas publicações. Evidenciou-se que ao longo dos anos houve uma evolução de pesquisas que abrangem a temática do espectro autismo. E, espera-se que este estudo contribua para a compreensão do desenvolvimento da pesquisa sobre autismo e educação no contexto brasileiro.
Bir Zamanlar Anadolu’da Filmi Bağlamında Türk Toplum Yapısında Bürokrasi, İktidar ve Kadın Görünümü
Authors: ŞANVERDİ Hatice
Published: May 2024

Nuri Bilge Ceylan's "Once Upon a Time in Anatolia" explores social dynamics and authority relations around a murder investigation set deep in Anatolia. The movie offers a good example of reading Turkish social structure through themes such as authority, hierarchy, bureaucracy and female innocence. Throughout the film, Power and hierarchy in the Turkish social structure reveals the authority structures and authority relations in the village society, while at the same time criticizing the bureaucratic structure in the society through bureaucracy, obstacles and dysfunction in the investigation process. Instead of the usual bureaucratic structure, Turkish society's perspectives, views and understanding of bureaucracy, authority and hierarchy relations and the manifestations of these concepts in society are seen. At the same time, it emphasizes the innocence of women, the powerlessness of female characters and the obligation to conform to social norms, thus opening up for discussion gender roles and the position of women in society. It tries to explain the Turkish social structure's perspective on women in the context of concepts such as innocence and punishment, as well as in the context of women and gender roles. In a general context, the relationship between concepts such as dichotomies, power, authority, bureaucracy and the Turkish social structure is revealed. The quiet and isolated village life of Anatolia actually harbors the complexity of social dynamics and power relations. By reflecting this complexity, the film allows for a deeper understanding of Anatolian society. "Once Upon a Time in Anatolia" is not just the story of a murder investigation, but rather a social and sociological portrait that examines the complexity of social structures and relations. Keywords- Authority Bureaucracy, Turkish Social Structure Woman
O potrzebie modyfikacji kręgu podmiotów uprawnionych do dochodzenia odszkodowania i zadośćuczynienia z art. 8b usta- wy z 23 lutego 1991 r. o uznaniu za nieważne orzeczeń wydanych wobec osób represjonowanych za działalność na rzecz niepodległego bytu Państwa Polskiego
Authors: Zgoliński Igor , Oczkowski Tomasz
Published: May 2024

Artykuł odnosi się do zagadnienia zaniechania ustawodawczego wynikłego na tle stosowania przepisów ustawy z 23 lutego 1991 r. o uznaniu za nieważne orzeczeń wydanych wobec osób represjonowanych za działalność na rzecz niepodległego bytu Państwa Pol-skiego. Autorzy postulują pilne zmiany nowelizacyjne zmierzające do rozszerzenia kręgu podmiotów uprawnionych do dochodzenia roszczeń w oparciu o art. 8b powołanej ustawy. Obecny stan prawny – zbyt wąsko ujęty – jest bowiem nie do pogodzenia z zasadami słuszności i sprawiedliwości społecznej. Z uwagi na dotychczasowe wyraźne intencje ustawodawcy oraz sam charakter ustawy nie jest możliwe sanowanie tego stanu rzeczy przez sądy w drodze zwykłej wykładni rozszerzającej przepisu.
Służba zagraniczna w Chinach: rozważania na tle rozwiązań prawnomiędzynarodowych
Authors: Łagiewska Magdalena
Published: May 2024

Podstawowym aktem normatywnym regulującym problematykę służby zagranicznej w Chińskiej Republice Ludowej jest ustawa o personelu dyplomatycznym stacjonującym za granicą. Oprócz tego chiński ustawodawca uchwalił osobne przepisy w zakresie przywilejów i immunitetów konsularnych. Celem artykułu jest przybliżenie specyfiki chińskiej służby zagranicznej na tle rozwiązań przyjętych w konwencji wiedeńskiej o stosunkach dyplomatycznych – i odpowiednio: konsularnych – oraz próba odpowiedzi na pytanie, czy chińskie rozwiązania odpowiadają standardom międzynarodowym w tym zakresie.
Immunitet dyplomatyczny i konsularny w regulacjach polskiego prawa karnego
Authors: Kolendowska-Matejczuk Marta
Published: May 2024

Artykuł omawia zagadnienia związane z uregulowaniem immunitetu dyplomatycznego i konsularnego w przepisach kodeksu postępowania karnego. Poruszona została kwestia relacji prawa międzynarodowego do prawa krajowego w tym zakresie i rozbieżności, jakie ujawniają się pomiędzy wskazanymi systemami prawa.
أثر تطبيق الأنظمة الالكترونية بالموارد البشرية على مستوى أداء الإدارة الصحية في مستشفى الملك فيصل التخصصي بجدة من وجهة نظر الأطباء والإداريين (دراسة حالة)
Authors:   ماجستير إدارة الأعمال، كلية جدة العالمية، المملكة العربية السعودية, العتيبي نجلاء , السلمي ماجد ,   دكتوراه الإدارة التربوية، إدارة تعليم جدة، المملكة العربية السعودية
Published: May 2024

هدفت هذه الدراسة للتعرف على أثر تطبيق الأنظمة الإلكترونية بالموارد البشرية على مستوى أداء الإدارة الصحية في مستشفى الملك فيصل التخصصي بجدة من وجهة نظر الأطباء والاداريين، ولتحقيق أهداف الدراسة استخدم الباحثان المنهج الوصفي باستخدام أسلوب دراسة حالة، وقد تكونت عينة الدراسة من (48) طبيب و(48) موظف إداري، وقد استخدم الباحثان الاستبانة كأداة للدراسة، وتوصلت الدراسة إلى عدة نتائج من أبرزها: أن مستوى إلمام العاملين بقطاع خدمات الرعاية الصحية بمفهوم الأنظمة الإلكترونية مرتفع، وأن مستوى استراتيجيات وخطط تطبيق الأنظمة الإلكترونية كأحد متطلبات تطبيق الأنظمة الإلكترونية لتحسين جودة خدمات الرعاية الصحية مرتفع، وأن مستوى توفير الأمن الإلكتروني والسرية الإلكترونية كأحد متطلبات تطبيق الأنظمة الإلكترونية لتحسين جودة خدمات الرعاية الصحية مرتفع، وأن مستوى معوقات تطبيق الأنظمة الإلكترونية لتحسين جودة خدمات الرعاية الصحية مرتفع، ومن أهم تلك المؤشرات: عدم الاهتمام بتنمية الموارد البشرية العاملة على تشغيل النظام والعلاقات الإنسانية، وانخفاض الوعي الثقافي والاجتماعي لدى متلقي الخدمات الصحية بعمل الأنظمة الإلكترونية، وعدم قدرة متلقي الخدمات الصحية على استخدام الإنترنت. وتوصي الدراسة بعدة توصيات أهمها: تعزيز التوجيه والتفاعل مع الأنظمة الإلكترونية من خلال توفير التدريب المستمر للموظفين وتوعيتهم بفوائد واستخدام الأنظمة بشكل فعال، نشر ثقافة الأنظمة الإلكترونية في قطاع خدمات الرعاية الصحية في المملكة العربية السعودية. يجب أن تشمل هذه الاستراتيجيات تحسين العلاقات داخل الفرق وتعزيز الشعور بالتقدير بين الموظفين، مما يساعد في خلق بيئة عمل داعمة ومحفزة من الضروري التركيز على تحسين الرفاهية وتوفير الدعم للموظفين، خصوصًا فيما يتعلق بالضغوط النفسية والعمل تحت الضغط، وذلك لضمان أن يكونوا قادرين على أداء وظائفهم بكفاءة وفعالية، والاستمرار في تحسين العمليات الداخلية واستخدام النظم الصحية لخدمة أكبر عدد ممكن من المرضى والزوار.
Personal Earnings in Pakistan: Role of Information Communication Technology (ICT) and Livelihood Diversification
Authors: Mehmood Khalid , Awan Masood Sarwar , Ishfaq Muhammad , Malik Muhammad Nauman , Mehmood Tariq
Published: May 2024

The determination of factors explaining personal earnings has remained a matter of great interest among economists. This study explores important socioeconomic and demographic factors affecting personal earnings in Pakistan with a special focus on the contribution of ICT usage and livelihood diversification. Ordinary Least Squares (OLS) regression models have been estimated using the most recent available PSLM (2019-20) data published by the Pakistan Bureau of Statistics (PBS). After careful screening, the data has been restricted to only those individuals who earn either through farm, non-farm, or diversified livelihoods. The results suggest that the use of ICTs has a significant contribution to the earnings in Pakistan. Similarly, livelihood diversification i.e., participating in both farm and non-farm employment activities can greatly improve personal earnings. The non-farm sector also remarkably supports the agriculture-based Pakistan’s economy. Especially, the small landholders have to inevitably search for additional livelihood sources as risk coping strategy. Education is found one of the most important determinants of personal earnings. It is suggested that measures should be taken to improve access to ICTs and internet facilities at the national level with a special focus on the most backward areas. Moreover, the government may acknowledge and support the livelihood diversification strategies as a component of the national objective for job creation. Stringent efforts are recommended to ensure the provision of free and quality education for all with equal opportunities.
İslam Hukukunda Hîle-i Şer‘iyye Meselesi ve Buna Dair Bir Osmanlı Hukuku Tatbikatı
Authors: Korkmaz Salih
Published: May 2024

İslam hukukunda hîle-i şer‘iyye ihtilaflı bir mesele olarak karşımıza çıkmaktadır. Bununla birlikte İslam hukuk tarihinde bu müessese geniş bir çerçevede tatbik edilmiştir. Bu çalışma hiyel meselesini hîle-i şer‘iyye ve hîle-i bâtıla ayrımı yaparak önce hukuk, sonra sosyal cihetten tetkik etmiştir. Bu hukuki tetkik yapılırken İslam hukukunda hiyel meselesinin genel hukuk teorisi çerçevesinde ele alınmış ve hangi hîlelerin meşru hangilerinin gayrimeşru olduğu hususunda bir mikyas, bir ölçü ortaya koyulmuştur. Ayrıca Osmanlı Devleti’nde tatbik edilen bir misal (muamele-i şer‘iyye) üzerinden mesele somutlaştırılmış ve hîle-i şer‘iyyenin sosyal şartlarla münasebeti ele alınmıştır. Nihayet çalışma İslam hukukunda hiyel meselesini hukukî, sosyal ve tatbiki cihetten ele almaya bu surette hîle-i şer‘iyyenin İslam hukuk tatbikatındaki rolünü ortaya koymaya teşebbüs etmiştir. Neticede hilelerin şer’i ve bâtıl olmak üzere ikiye ayrıldığı, şer’i hîlelerin “hâcet” halinde müracaat edilebilecek hukukî bir yol olduğu, bu yolun da tarihi süreçte hukukun esnekliğini sağlamaya ve hukuki formalizmin aşılmasına yardımcı olduğu ortaya koyulmuştur.
Prosthetic Rehabilitation of a Maxillectomy Patient with Restricted Mouth Opening Using an Altered Cast Technique: A Case Report
Authors: G Naik Sadhvi , Mascarenhas Kennedy , Ajay Aras Meena
Published: May 2024

Deformity in the maxillofacial region caused by surgical resection of a tumor have an adverse effect on the patient's ability to swallow, masticate, phonate, and psychological state. These patients may have restricted mouth opening capacity due to several surgical procedures and scar contracture resulting from radiation therapy. Therefore due to restricted access to the oral cavity prosthetic rehabilitation of these patients becomes a challenging task.
A precise impression of the resection defect is necessary for accurate obturation. This is not practical for patients who have restricted mouth opening, hence this crucial first step in the making of a good prosthesis is frequently accomplished by altering the conventional impression method. This clinical report details the prosthetic rehabilitation of a patient who was diagnosed with Adenoid cystic carcinoma of the left maxillary sinus. Patient underwent maxillectomy for tumor removal, which was worsened by trismus as a result of the procedure and radiation therapy. For orofacial rehabilitation and defect obturation, the patient was restored with a removable dental prosthesis with a hollow bulb obturator. An altered cast technique was used in the final impression making. This rehabilitation approach was successful in restoring lost function and appearance of the patient.

Keywords: Maxillectomy, Hollow Obturator, Altered cast technique
Development of Banana Fabric Fruit Cover Finished with Neem Leaf Extraction
Authors: Kavitha V. , Navananthana S.S
Published: May 2024

Fruit covers, also known as fruit protection covers or fruit netting, are used in agro tech to provide a physical barrier around fruits. They are typically made of lightweight, breathable material that allows sunlight, air, and water to reach the fruit while keeping pests, birds, and other animals away. Fruit covers act as a shield against extreme weather conditions, such as hail, strong winds, or excessive rainfall, which can cause physical damage to the fruit. Fruit cover protects from damages caused by nature to the fruits. Banana fabric is used for fruit cover. It is breathable and biodegradable. Banana fiber has its own physical and chemical characteristics and many other properties that make it a fine quality fiber. Appearance of banana fiber is similar to that of bamboo fiber and ramie fiber, but its fineness and spinnability is better than the two. The chemical composition of banana fiber is cellulose, hemicellulose, and lignin .It is highly strong fiber .It has smaller elongation. It has somewhat shiny appearance depending upon the extraction & spinning process. Selected the neem leaf to prevent the fruits from insects. The herb was collected and washed thoroughly to get rid of insects if any were present in it. The leaves are plucked and taken for the next process. Double boiling method is used to extract neem leaf. In a double boiler, water is placed in a pot that sits on the burner. On top of the pot, a glass or metal bowl holds the ingredients you're cooking. The steam from the simmering water warms the contents of the bowl gently with indirect heat. Fruit cover has 70% breathability. It is done to confirm that the fruit cover is suitable for the fruit to grow. Tearable testing is 25% towards wet tearing an 20% towards dry tearing.

Keywords: Fruit cover, Extraction of neem leaf, Banana fabric, breathability, shield against extreme weather, Myrobalan
Design and Development of Ecofriendly Herbal Oil Infused Nail Polish Remover Tissues
Authors: Indumathi T.R. , Gokila S.
Published: May 2024

Natural nail polish removers have gained popularity as a safer and more environmentally friendly alternative to traditional acetone-based removers. This abstract provides a research work of the key features and benefits of natural nail polish removers, which are made from natural and non-toxic ingredients like plant-based solvents, essential oils, finished on natural and regenerated fibred nonwoven spun lace fabrics. These environment friendly techniques remove nail polish effectively without emitting foul chemical odors or harming cuticles and nails. The study introduces a nail polish remover solution featuring lemongrass oil as its primary active ingredient enriched with vitamin E oil. In response to the growing desire for natural cosmetic products, this study examines the efficiency and safety of composites made of lemongrass oil and vitamin E oil treated on fabric as a nail polish remover through antimicrobial testing and subjective analysis. The findings suggest that the proposed approach may be more effective than conventional nail polish removers in terms of user experience and environmental impact. Thus, in response to the growing demand for natural and non-toxic beauty products, this natural nail polish removers were developed and embraced, which has assisted the beauty industry in becoming more environmentally and health conscious.

Keywords: Nail polish remover, acetone, viscose fabric, lemongrass oil, vitamin E, and eco-friendly
Impact of Penetration Enhancer and Natural Oil on Transdermal Delivery of Modified Karaya Gum Gel
Authors: Madhavi Nimmathota , Sudhakar Beeravelli
Published: May 2024

The etodolac based modified karaya gum (MKG) gel was developed using 32 factorial design to enhance the therapeutic effect of gel to treat inflammation. Gels were prepared with different concentrations of MKG and arachis oil using 32 factorial design. The percentage of drug content was found in the range of 96 to 99%, viscosity results shown in the range of 842 CPS to 2560 CPS and in vitro drug release was found to be in range of 38% to 98% respectively. Whereas ex-vivo permeation studies of etodolac gel and pure etodolac solution across the burned pig skin were shown 72% and 42% respectively. The drug and excipient compatibility studies by FTIR confirms that, there is no major functional group change was observed. The results concluded that, the combination of MKG and arachis oil were improved the penetration of etodolac through burned pig skin thereby the combination of PE and oil successfully enhanced the therapeutic effect of etodolac.
Analysis of Total Flavonoid and Total Phenolic Content of Red Algae (Eucheuma denticulatum (Burman) Collins et Harvey) Extract and Tempeh Extract
Authors: Syakri Syamsuri , Sartini Sartini , A. Miskad Upik , Aminuddin Aminuddin , Amir Tahir Karlina , Jalaluddin Syatirah , Masri Anshari
Published: May 2024

The red seaweed Euchema denticulatum (commonly referred to by the trade name Spinosum) is primarily farmed for extraction of carrageenan for application in foods. Tempe is a fermented soybean dish that is well-known for having a lot of protein. In the world, there are various ways to make tempeh, including soaking it in vinegar before fermentation. This study aims to determine the levels of total flavonoids and total phenolics in red algae and tempeh samples. Total phenolic content test was carried out using the Folin-Ciocalteu method using UV-Vis spectrophotometry at a wavelength of 760.5 nm. Total Flavonoid content test for total phenolic content was carried out quantitatively using a uv-vis spectrophotometer at a wavelength of 370 nm. The results showed that the average total flavonoid content in red algae was 55.25 mg/kg, and the total phenolic content in red algae was 420.56 mg/kg. whereas in tempeh the average total flavonoid content in red algae was 223.20 mg/kg, and total phenolic in tempe was 736.40 mg/kg.
Development and Validation of a Rapid and Sensitive LC-APCI-MS/MS Method for the determination of three N-nitrosamine impurities in Varenicline tartrate drug substance and drug products
Authors: Vidyamani Uppalapati , Ramachandran Dittakavi , Durga Babu Mannem , Murthy Raju Sagi Samba , Uma Maheswar Korrapati
Published: May 2024

Nitrosamines impurities may be present in low levels in a variety of products that people are exposed to every day. After thorough investigations, regulatory agencies have outlined that the formation of nitrosamines is possible in the presence of secondary, tertiary, or quaternary amines and nitrite salts under acidic reaction conditions. For safety purpose, all API manufacturers must be developed methods to monitor the low levels of each nitrosamine impurity before the release the individual batches. In this article, we have developed novel, rapid and sensitive liquid chromatography Atmospiric pressure chemical ionization Mass spectroscopy (LC-APCI-MS/MS) method for the determination of N-Nitroso Dimethylamine (NDMA), N-Nitroso Diethylamine (NDEA) and N-Nitroso varenicline impurities in the Varenicline Tartrate drug substance and Drug products. Chromatographic separation is achieved using Inert sustain AQ C18 150 × 4.6mm, 3.0μ column with 0.1% formic acid in water as mobile phase A and 0.1% formic acid in methanol as mobile phase B at the 0.6 mL/min flow rate by using gradient mode of elution upto the 25 minutes total run time. The three impurities are successfully ionized and quantified in positive mode of atmospheric pressure chemical ionization (APCI) using multiple reaction monitoring (MRM). This method was validated according to ICH Q2 (R1) guidelines. The method provided excellent S/N ratios with a high linearity range of 0.66-19.88 ppm with respect to Varenicline Tartrate sample concentrations with a regression coefficient >0.995. The recovery for the method was established with a protocol of three-step sample preparation and was satisfactory within 85-115%. The determined LOQ (0.66 ppm) and LOD (0.22 ppm) values are very low with respect to sample concentration which shows the sensitivity Performance of the method. The method can be routinely applied for the detection of N-nitrosamine impurities (NDMA, NDEA and N-Nitroso varenicline) in Varenicline Tartrate drug substance and Drug products.
Synthesis, Characterization and Docking Studies of Novel Series of Benzothiazoles for Anticancer Activity
Authors: V Shahare Hitesh , H. Shahare Shweta , B. Amrute Bhavesh , N. Ansari Yunus , S. Borkar Vijay , N. Kapse Sachin , Patil Yogesh
Published: May 2024

Background: Cancer is the main cause of mortality worldwide, accounting for the majority of deaths. There is a therapeutic need for innovative, selective anti-tumor medicines that avoid most of the undesirable negative reactions linked to current chemotherapy regimens. The receptor for epidermal growth factor (EGFR) is a membrane glycoprotein, and mutations that cause EGFR overexpression or overactivity have been linked to a range of human malignancies. Objective: In light of this, benzothiazole compounds were developed and produced as EGFR inhibitors, which could possibly form a new class of successful cancer therapies. Experimental work: In this study, we synthesized novel [4-(1H-benzothiazol-2-yl) phenyl] amides derivatives. Furthermore, these produced compounds were subjected to molecular docking experiments to elaborate on interaction and chemistry in order to determine their affinity for the target. After confirming their molecular makeup, these compounds were tested for anticancer efficacy. Result and Discussion: Benzothiazole molecules were effectively synthesized, and their molecular structures were verified using protons NMR and IR spectra. The cytotoxic activity of these novel compounds was determined using the SRB technique. Conclusion: The present investigation involves the targeted chemotherapy to plausibly reverse, suppress or prevent cancer. Synthesized compounds revealed good cytotoxic effect and have shown more potential. So, in future, these effective molecules will be explored for increasing their affinity towards different targets, so they can be used against various cancers.
Preclinical Evaluation of Paederia foetida leaves for Burn Wound Healing Activity
Authors: Roy Santanu , Ghosh Susmita , Pramanick Krishanu , Roy Prodip , Majumdar Mrityunjoy , Roy Sourav
Published: May 2024

The leaves of Paederia foetida are commonly used in folk remedies to treat various types of wounds, especially burn wounds. The present study was carried out to evaluate the effect of hydroalcoholic extract of Paederia foetida on experimentally induced burn wound in rats and compare the effects with known wound healing agents, Silverex ointment and Aloe veragel. An appropriate gel formulation was chosen for topical application in this burn wound model. Animals treated with Paederia foetida leaves extract showed significant reduction in period of epithelialization and wound contraction 50% as compare to control and produced comparable effect as compare to Silverex ointment and Aloe vera gel. From the study It was concluded that Paederia foetida leaves extract applied topically (2.5% and 5% gel formulation) possesses burn wound healing activity.
Ciplukan (Physalis angulata Linn) Bioactivity against Bleomycin-Induced Pulmonary Fibrosis in Mice by reducing Subpleural Fibrosis, KL-6 Level and Anti-Inflammatory properties
Authors: Dewi Sumartini , Rohmawaty Enny , Rosdianto Aziiz Mardanarian , Aminah Usman Hermin , Zuhrotun Ade , Hendriani Rini , Wardhana Yoga Windhu , Ekawardhani Savira , Lina Wiraswati Hesti , Dimas Kulsum Iceu , Reza Rahmadi Andri , H. Pranggono Emmy
Published: May 2024

Pulmonary fibrosis is a fatal lung disease with unknown pathogenesis and limited treatment options. Herbal medicine began to be developed as an antifibrosis drug for this disease. Ciplukan plant (Physalis angulata Linn.), is a wild plant that has been widely used for generations as traditional Indonesian medicine for various diseases; but has never been studied as an antifibrosis. This study aimed to determine Ciplukan herb ethanol extract (CPL) bioactivity as antifibrosis in pulmonary fibrosis disorders in experimental mice model induced by bleomycin. A total of 35 male mice and 35 female mice of the ddy strain was divided into 7 groups respectively with 1 normal control group and 6 experimental animal models of pulmonary fibrosis induced by bleomycin groups. For the pulmonary fibrosis model, bleomycin (BLM) was injected subcutaneously 8 times with a frequency of twice a week for 4 weeks. Furthermore, the mice were given CPL orally starting at week 6 of treatment with 2 different doses, 1.95mg (CPL-1) and 3.9mg (CPL) every day for 4 weeks. Pulmonary fibrosis histopathology was analyzed using HE and MT staining methods. Serum IL-6, KL-6, and TGF-β1 levels determination was carried out using the ELISA method. The administration of CPL significantly reduced the fibrosis score from 2.80±1.095 to 1.67±0.577µm (p=0.026). The CPL also showed anti-inflammatory activity by reducing IL-6 levels from 1916.20±594.27 to 16.81±17.07pg/mL (p=0.003); TGF-β1 levels from 51.25±2.25 to 22.48±0.93ng/mL (p=0.021); and KL-6 levels from 28.09±2.25 to 13.99±0.93ng/mL (p=0.000). CPL was proven to have pulmonary antifibrotic activity in experimental mice model. The pulmonary antifibrotic effect was evidenced by a decrease in pulmonary fibrosis scores also a decrease in KL-6 levels, IL-6 levels, and TGF-β1. The administration of CPL-1 and CPL-2 can provide recovery of pulmonary fibrosis induced by bleomycin.
Development and Characterization Pioglitazone Hydrochloride Loaded Nanoparticle for Management of Diabetes Mellitus
Authors: Prasad Meena Kedar , Kumar Sahu Bishesar , Karri Tripty , Samal Pradeep , Yadav Sandeep , Jaiswal Divya
Published: May 2024

The potential applications of nanoparticles as oral drug delivery systems for diabetes treatment are discussed in this research article. This paper discusses polymeric nanoparticles, polysaccharides, and polymeric nanoparticles in the oral administration of anti-diabetic drugs. Diabetes is a chronic metabolic disorder characterized by insulin deficiency. Diabetes treatments are numerous, and nanoparticles have several advantages. Several studies and research reports based on nanotechnological approaches in the formulation of anti-diabetic drugs have highlighted the fact that research in the formulation of nanodrugs improved diabetes-fighting strategies based on plausible molecular mechanisms of action of the drugs. Additionally, efforts have been made to determine the optimal drug concentration and time of exposure in order to recommend a scientifically validated drug dose response in the development of various therapeutic strategies for anti-diabetic drugs, various types of nanoparticles are available; polymeric nanoparticles are one of the most commonly used nanoparticles. Polymeric nanoparticles range in size from 10-1000 nm. Polymeric nanoparticles created by combining a drug and a polymer. The main advantages of polymeric nanoparticles are their ease of preparation, targeted delivery, dose minimization, and high therapeutic efficiency.
Posaconazole-glutaric acid cocrystal tablet with improved Dissolution rate
Authors: Nijhawan Monika , Saxena Trapti , Dhyagala Sadhna , Sailaja Gunnam , Aleti Rajeswari
Published: May 2024

Posaconazole is used to prevent fungal infections in patients having severely weakened immune system and has poor aqueous solubility which impairs its dissolution in upper gastric fluid producing problems in different formulations. These characteristics hinder its therapeutic application by delaying absorption rate and thereby onset of action. In the present study, an attempt was made to prepare posaconazole cocrystals with improved physicochemical properties for better therapeutic activity. Cocrystals were prepared with glutaric acid in 1:1 molar using ethanol by solvent drop grinding technique. The co-crystals formed were characterized by melting point determination, fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and dissolution studies. Posaconazole-glutaric acid co-crystals were further formulated as fast disintegrating tablets. The IR study revealed the shifting of characteristic bands of posaconazole. The PXRD pattern indicated cocrystal crystallinity and a considerable difference in 2θ value of intense peaks. The variation in fusion endotherm, which is in agreement with melting point, was designated by DSC spectra of posaconazole cocrystal. A significant improvement in the dissolution rate was observed in the case of cocrystals based tablets than pure posaconazole tablets.
Formulation of Effervescent Tablet from Kelulut Bee (Trigona sp.) Pollen from East Kalimantan
Authors: Dwi Nugraha Alfin Syahrian , Mariana Kustiawan Paula , Chairin Hanifa Deasy Nur , Muris Setiawan Irfan
Published: May 2024

Since the beginning of human history, bee honey has been used by humans. However, there are also other bee products such as bee pollen (BP), royal jelly, propolis, and beeswax. Previous research has identified that pollen contains amino acids, lipids, flavonoids, micronutrients and many fat-soluble vitamins such as vitamins A, E and D, as well as water-soluble vitamins such as vitamins B1, B2, B6 and C. The objective of this study is to formulate bee pollen as effervescent tablet. The method in this study used alkaline granulation which requires an oven process for 24 hours and the use of a combination of sodium bicarbonate with citric acid. Three formulas were optimized in this study. The stability test results showed that formula number 3 has an average moisture content of 0.5696±0.6154%, and average flow rate of 0.67±0.02054 g/sec, the average compressibility in formula number 1 is 0.046±0.0452%. Overall, it is also known that formula number 2 has the smallest dissolution time compared to other formulations. The effect of the combination of citric acid and sodium bicarbonate used in the formulation of effervescent tablets from bee pollen on the physical quality of the tablets, namely friability, hardness, and dissolving time, the higher levels of citric acid and sodium bicarbonate used do not have a significant effect on friability, hardness, and time dissolving effervescent tablets from bee pollen from kelulut bees (Trigona sp).
Formulation, Evaluation and Study of Super Disintegrants effect on Olmesartan Medoxomil Fast Dissolving Tablets
Authors: Ramu Anne , Vidyadhara Suryadevara , Ramesh Babu Janga , Sowjanya Lakshmi Battula , Ramya Krishna Seelam
Published: May 2024

The current research was to enhance solubility and dissolution rate of the slightly soluble drug, Olmesartan medoxomil, solid dispersions by physical mixing, solvent evaporation and kneading techniques, with soluplus. The solid dispersions prepared are tested for flow properties, drug content, and particle size. In vitro dissolution studies were carried out to analyse the drug release from solid dispersions. Crystal morphology, drug and polymer interaction for selected solid dispersions was studied by FT-IR and DSC analysis. Fast-dissolving tablets were formulated by using optimized solid dispersions using different concentrations of sodiumstarch glycolate, crosscarmellosesodium, and crospovidone as superdisintegrants using direct compression technique. The tablets prepared are tested for Weight variation, friability, disintegration, content uniformity and harness. The mechanism and kinetics of drug release from the fast-dissolving tablets were tested by in-vitro dissolution studies. The current research proves that combining solid dispersions along with the use of superdisintegrants is novel approach to formulate of Olmesartan medoxomil fast-dissolving tablets.
An In vitro Study on impact of Vitamin-C on Cefuroxime mediated alterations in Bio-parameters associated with free Radical linked Lipid Decomposition
Authors: Ghosh Madhurima , Kumar Ghosh Miltu , Devbhuti Debabrata , Dasgupta Sandipan , Devbhuti Pritesh
Published: May 2024

Background: Lipid peroxidation can be interpreting as an oxidative degeneration of lipids. It happens when a hydroxyl radical removes an electron from polyunsaturated fatty acids (PUFAs), which can react with oxygen and other polyunsaturated fatty acids to produceperoxyl radicals and hydroperoxides, thus promulgating the injury. So this repeat cycle of lipid peroxidation process can be responsible of cellular damage. Drug-induced lipid peroxidation is an important phenomenon found to be involved behind it’s certain hazardous side effects due to the generation toxic end products of such peroxidation like malonaldehyde (MA), hydroxynonenal (HNE), etc. Antioxidants play a crucial role in modifying such processes due to their free radical scavenging capability. Objective: Keeping in mind the matter, thisin vitroinvestigation was conducted using cefuroxime, a cephalosporin antibiotic as drug of choice and vitamin C as antioxidant taking liver tissue of goat as lipid source. Methods: The liver homogenate was divided in certain experimental groups that were treated with cefuroxime and ascorbic acid for specific time periods. The level of MA and HNE in the samples was estimated and compared with control. Result: The result showed that Cefuroxime has lipid peroxidation induction capability that was counteracted by ascorbic acid. Conclusion: Thus cefuroxime-induced, peroxidation associated, toxicities may be managed well upon co-administration with the antioxidant vitamin C.
A Bibliometric Analysis of Equity Financing in Small and Medium Sized Enterprise: Trends, Patterns, and Future Directions
Authors: Pramono Irena Paramita , Abu Hassan Mohamad Hanif , Ahmad Nadzri Farah Aida
Published: May 2024

Using bibliometric analysis, the purpose of this study is to conduct a review of previous scholarly work in business economics pertaining to entrepreneurial equity financing that has been completed throughout the past three decades (1987–2023). To accomplish this, 133 documents related to this subject were taken from the Scopus database and arranged in accordance with the following criteria: the number of publications per year, the articles with the most citations, the authors with the most renown, the journals with the highest citation rate per article, and the countries with the highest overall productivity. In addition, our research provides clusters determined by the co-occurrence analysis of keywords to determine the primary topics that were looked into. Our findings can be used to understand entrepreneurial equity finance better and pinpoint potentially fruitful study areas for further investigation in the near and distant future.
A long-term study of the impact of the invasive species Eurasian minnow Phoxinus phoxinus on brown trout Salmo trutta production in a high mountain lake, Southern Norway
Authors: Qvenild Tore , Hesthagen Trygve , Museth Jon
Published: May 2024

The shallow Lake Skjerja was originally one of the most outstanding brown trout lakes on the Hardangervidda mountain plateau. During the period 1973–1985, the annual yield was on average 3.35 kg ha-1. In the mid-1980s, Eurasian minnow established a dense population in the lake. Since 1994, 5304 kg of Eurasian minnow have been removed with baited traps, which correspond to an annual mean catch of 177 kg year-1 or 1.12 kg ha-1. The competition for food, in addition to longer food chains, has had a strong negative impact on the brown trout production, with an annual yield reduced to 1.07 kg ha-1, or 32% of the historical catches (1973-1985). The total removed biomass of the two fish species correspond to 65% of the brown trout yield before the invasion of the Eurasian minnow. In Lake Skjerja, the two crustacean species Gammarus lacustris and Lepidurus arcticus, have historically been staple food items for brown trout. Fishing with baited traps on the minnows, and the presence of a large fraction of predatory brown trout, may have reduced the predation pressure on the two crustacean species, and they are still a part ofthe brown trout diet. The availability of fish as food has resulted in a significant increase in the presence of large individuals of brown trout with maximum weights above four kg. Despite reduced annual yield of brown trout, Lake Skjerja is still a popular fish destination with nearly 200 big-sized brown trout (mean annual weight 1065 grams) landed annually. On Hardangervidda, an increase in air temperature has been observed since the 1980s, with a corresponding change in water temperature which may benefit Eurasian minnow. In warm summers, water temperature approaches 14°C which has proved to be near to the upper thermal threshold for Lepidurus arcticus.
Detecção de Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis e Mycoplasma genitalium em municípios do Nordeste brasileiro: implantação piloto do serviço nacional de testes moleculares em gestantes
Authors: Diniz Ítalo Vinícius Albuquerque , Gaspar Pâmela Cristina , Lannoy Leonor Henriette de , Souza Isabella Mayara Cleide Diana Mariana Nepomuceno de , Cravo Neto Draurio Barreira , Miranda Angélica Espinosa Barbosa , Bazzo Maria Luiza , Schörner Marcos André , Barazzetti Fernando Hartmann , Rodrigues Samara Carolina
Published: May 2024

Introdução: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) e Mycoplasma genitalium (MG) são agentes que causam infecções que não são de notificação compulsória no Brasil, impedindo estimar a magnitude do problema. Objetivo: Descrever resultados da implantação piloto do Serviço Nacional de Diagnóstico Molecular de CT/NG/MG/TV, realizado no Brasil, entre as gestantes da região Nordeste. Métodos: Participaram da estratégia piloto no Nordeste os municípios de Recife, Fortaleza, Salvador e Natal. Para coleta de um espécime de esfregaço vaginal em gestantes de 15 a 49 anos foi utilizado o Aptima Collection Kit (HOLOGIC) e enviado ao laboratório de referência usando Aptima Assays (HOLOGIC) para detecção de CT/NG/MG/TV. A análise descritiva das variáveis foi realizada por meio de frequência relativa e absoluta, medidas de tendência central e dispersão. Resultados: Das 572 gestantes atendidas no âmbito do estudo piloto: 41% residiam em Recife e 26,6% em Fortaleza; a média de idade foi de 27 anos (desvio padrão [DP]+6,9); 41,4% se autodeclararam pardas; 31,5% tinham escolaridade igual ou maior a oito anos; 44,1% tinham renda familiar de até 1,9 salário mínimo; 17,8% relataram nunca terem realizado exame citopatológico; 16,6% tiveram a primeira relação sexual antes dos 15 anos; 74,1% eram assintomáticas para infecções sexualmente transmissíveis (ISTs); e 20,8% apresentaram positividade para um ou mais de um dos patógenos (CT/NG/MG/TV). A taxa de detecção foi de 10,3% para CT, 9,4% para MG, 5,1% para TV e 1% para NG. Do total de casos, 21,8% correspondiam a coinfecções, sendo CT/MG (46,2%) e MG/TV (15,4%) as mais frequentes, assim como em três patógenos: CT/MG/TV (7,7%) e CT/NG/TV (3,8%). Conclusão: A elevada proporção de casos na região reforça a importância da implementação de testes moleculares na rede pública, além da necessidade da implementação de estratégias para a prevenção de ISTs e do estímulo para o desenvolvimento de políticas públicas voltadas para o pré-natal.
Casos novos de tuberculose multidrogarresistente vivendo com HIV no Brasil, 2013 a 2022
Authors: Mello Mariana Sanches de , Heráclio Isabela D. E. Lucena , Arroyo Luiz Henrique , Silva Júnior José Nildo de Barros , Pelissari Daniele Maria , Cervieri Geisa Poliane de Oliveira , Dockhorn Fernanda , Guimarães Luciana Nogueira de Almeida , Rodrigues Samara Carolina
Published: May 2024

Introdução: O tratamento da tuberculose multidrogarresistente (TB MDR) caracteriza-se por um complexo cenário clínico que implica utilização de drogas especiais por um período mais prolongado que o tratamento da tuberculose (TB) sensível. Quando associada ao HIV, acrescenta-se a necessidade da terapia antirretroviral (TARV), o que aumenta a quantidade de medicamentos ingeridos, possíveis efeitos adversos e as chances de descontinuidade de ambos os tratamentos. Objetivo: Descrever os casos novos de TB MDR vivendo como HIV. Métodos: Estudo descritivo realizado com dados extraídos do Sistema de Informação de Tratamento Especial da Tuberculose (Site-TB), de 2013 a 2022. Consideraram-se casos de TB MDR cujo padrão de resistência inicial foi classificado com resistência à rifampicina e multirresistência. Resultados: Foram notificados 6.390 casos novos de TB MDR; destes, 5.504 (86,1%) apresentavam resultado de teste para HIV, sendo 4.597 (83,5%) negativos e 907 (16,5%) positivos. Os casos novos de coinfecção TB MDR-HIV eram do sexo masculino (n=605, 66,7%), raça/cor parda (n=418, 46,1%), escolaridade de 4 a 7 anos (n=396, 40,7%), faixa etária entre 30 e 34 anos (n=170, 18,7%) e residiam nos estados do Rio de Janeiro (n=198, 21,8%), Rio Grande do Sul (n=197, 21,7%) e São Paulo (n=122, 13,5%). Na maioria (n=650, 71,7%), a informação sobre o início da TARV estava em branco/ignorada; entretanto, em 183 (20,2%) casos a TARV foi iniciada. A resistência adquirida (n=492, 54,2%) foi predominante. Sobre o encerramento, até o ano de 2020, 214 (29,3%) interromperam o tratamento e 96 (13,1%) evoluíram a óbito. Conclusão: O atraso no tratamento da coinfecção está relacionado à piora do prognóstico, especialmente em pacientes com imunossupressão. Reforça-se a necessidade de melhorar o preenchimento das informações sobre a testagem de HIV e o início da TARV no Site-TB. Além disso, destaca-se a maior proporção de resistência adquirida, que resulta do inadequado ou incompleto regime de tratamento.
Seguimento de lactentes com sífilis congênita durante o período de escassez de penicilina
Authors: Rocha Ana Fatima Braga , Araujo Maria Alix Leite , Oliveira Ana Karinne Dantas de , Pimentel Lea Dias Gomes Vasconcelos , Melo Adriana Lopes Lima
Published: May 2024

Introdução: Como as manifestações clínicas da sífilis congênita (SC) podem ocorrer após o período neonatal, é necessário que, mesmo quando tratado na maternidade, o lactente seja encaminhado e tenha acompanhamento ambulatorial até os 18 meses de idade. Objetivo: Analisar o seguimento, em ambulatórios especializados, de lactentes notificados com SC durante a escassez de penicilina. Métodos: Estudo transversal realizado em dez maternidades públicas conveniadas ao Sistema Único de Saúde (SUS) de Fortaleza, Ceará. Os registros clínicos de bebês notificados com SC que nasceram vivos em 2015 foram utilizados para descrever correlatos de comparecimento às consultas de acompanhamento clínico recomendadas. Resultados: Um total de 469 lactentes notificados com SC de 1º de janeiro a 31 de dezembro de 2015 foi incluído na análise. Os resultados mostram que a maioria dos bebês não compareceu às consultas de acompanhamento (368/469, 78,5%) e os principais fatores associados são que o ambulatório de acompanhamento está localizado em um hospital diferente daquele no qual o bebê nasceu (odds ratio [OR]: 3,7, intervalo de confiança [IC] 2,20–6,22, p<0,001) e o uso de drogas ilícitas pela mãe (OR: 3,2, IC 1,57–6,87, p=0,002). Apenas 33,7% (34/101) foram acompanhados até a alta. Conclusão: A maioria das crianças com SC notificada nesse período não compareceu às consultas de acompanhamento. Os esforços de saúde pública destinados a chegar aos pais de crianças com SC devem ser uma prioridade para garantir a identificação clínica adequada e o manejo dos resultados associados dessa infecção transmitida verticalmente.
Sexual Behavior and Association with Sexually Transmitted Infections in Vulnerable Populations in a City of Goiás
Authors: Marques Cristhiane Campos , Trombetta Marihá Thaís , Camargo Júnior Elton Brás , Mariz Fabiana Nunes de Carvalho , Moreira Berenice
Published: May 2024

Background: The population living in therapeutic clinics faces several weaknesses, especially concerning health-related aspects. Due to limited accessibility to health services, testing for infectious diseases and corresponding treatments are neglected. This scenario, added to risk behaviors, contributes substantially to the high incidence of sexually transmitted infections (STIs) in the population under analysis. Objective: To understand the prevalence of STIs in the population living in therapeutic clinics. Methods: This study, conducted through the Scientific Initiation Program and approved by the Research Ethics Committee, adopted a cross-sectional and descriptive approach, based on a quantitative perspective. The focus was on interviews conducted with residents of therapeutic communities located in the city of Rio Verde, Goiás. The data were obtained through the service form of the Counseling and Testing Center (CTA – Centro de Testagem e Aconselhamento), as well as a script with questions that cover the variables relevant to the study. Additionally, serological tests were conducted, including anti-HIV, syphilis, and hepatitis B and C antibodies. Results: The collected responses show the presence of vulnerabilities in this population group. A considerable portion devalues the use of condoms, adopts risky sexual behaviors, and demonstrates ignorance about the prevention measures of STIs, as well as the prophylactic therapies available. In addition, there was a significant prevalence of depressive symptoms among the patients evaluated, often correlated with the use of psychoactive substances. Although the positive serological results were numerically limited, all individuals in this situation were referred to the appropriate health services. Conclusion: Given the above, the importance of implementing specific public policies to meet the particular demands of individuals living in therapeutic clinics is emphasized.