bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification and genetic engineering of pneumococcal capsule-like polysaccharides in commensal oral streptococci
Authors: Wu Ren , Nahm Moon , Yang Jinghua , Bush C. Allen , Wu Hui
Published: April 2024

Capsular polysaccharides (CPS) in
Streptococcus pneumoniae
are pivotal for bacterial virulence and present extensive diversity. While oral streptococci show pronounced antigenicity toward pneumococcal capsule-specific sera, insights into evolution of capsule diversity remain limited. This study reports a pneumococcal CPS-like genetic locus in
Streptococcus parasanguinis
, a predominant oral
Streptococcus
. The discovered locus comprises 15 genes, mirroring high similarity to those from the Wzy-dependent CPS locus of
S. pneumoniae
. Notably,
S. parasanguinis
elicited a reaction with pneumococcal 19B antiserum. Through nuclear magnetic resonance analysis, we ascertained that its CPS structure matches the chemical composition of the pneumococcal 19B capsule. By introducing the glucosyltransferase gene
cps19cS
from a pneumococcal serotype 19C, we successfully transformed
S. parasanguinis
antigenicity from 19B to 19C. Furthermore, substituting serotype-specific genes,
cpsI
and
cpsJ
, with their counterparts from pneumococcal serotype 19A and 19F enabled
S. parasanguinis
to generate 19A- and 19F-specific CPS, respectively. These findings underscore that
S. parasanguinis
harbors a versatile 19B-like CPS adaptable to other serotypes. Remarkably, after deleting the locus’s initial gene,
cpsE
, responsible for sugar transfer, we noted halted CPS production, elongated bacterial chains, and diminished biofilm formation. A similar phenotype emerged with the removal of the distinct gene
cpsZ
, which encodes a putative autolysin. These data highlight the importance of
S. parasanguinis
CPS for biofilm formation and propose a potential shared ancestry of its CPS locus with
S. pneumoniae
.

IMPORTANCE

Diverse capsules from
Streptococcus pneumoniae
are vital for bacterial virulence and pathogenesis. Oral streptococci show strong responses to a wide range of pneumococcal capsule-specific sera. Yet, the evolution of this capsule diversity in relation to microbe-host interactions remains underexplored. Our research delves into the connection between commensal oral streptococcal and pneumococcal capsules, highlighting the potential for gene transfer and evolution of various capsule types. Understanding the genetic and evolutionary factors that drive capsule diversity in
S. pneumoniae
and its related oral species is essential for the development of effective pneumococcal vaccines. The present findings provide fresh perspectives on the cross-reactivity between commensal streptococci and
S. pneumoniae
, its influence on bacteria-host interactions, and the development of new strategies to manage and prevent pneumococcal illnesses by targeting and modulating commensal streptococci.
Biogeographical and biodiversity patterns of planktonic microeukaryotes along the tropical western to eastern Pacific Ocean transect revealed by metabarcoding
Authors: Fu Yingjun , Qu Zhishuai , Wang Ying , Sun Ping , Jiao Nianzhi , Xu Dapeng
Published: April 2024

Microeukaryotic plankton (0.2–200 µm), which are morphologically and genetically highly diverse, play a crucial role in ocean productivity and carbon consumption. The Pacific Ocean (PO), one of the world’s largest oligotrophic regions, remains largely unexplored in terms of the biogeography and biodiversity of microeukaryotes based on large-scale sampling. We investigated the horizontal distribution of microeukaryotes along a 16,000 km transect from the west to the east of the PO. The alpha diversity indices showed a distinct decreasing trend from west to east, which was highly correlated with water temperature. The microeukaryotic community, which was clustered into the western, central, and eastern PO groups, displayed a significant distance-decay relationship. Syndiniales, a lineage of parasitic dinoflagellates, was ubiquitously distributed along the transect and dominated the community in terms of both sequence and zero-radius operational taxonomic unit (ZOTU) proportions. The prevailing dominance of Syndiniales-affiliated ZOTUs and their close associations with dinoflagellates, diatoms, and radiolarians, as revealed by SparCC correlation analysis, suggested that parasitism may be an important trophic strategy in the surface waters of the PO. Geographical distance and temperature were the most important environmental factors that significantly correlated with community structure. Overall, our study sheds more light on the distribution pattern of both alpha and beta diversities of microeukaryotic communities and highlighted the importance of parasitisms by Syndiniales across the tropical PO.

IMPORTANCE

Understanding the biogeographical and biodiversity patterns of microeukaryotic communities is essential to comprehending their roles in biogeochemical cycling. In this study, planktonic microeukaryotes were collected along a west-to-east Pacific Ocean transect (ca. 16,000 km). Our study revealed that the alpha diversity indices were highly correlated with water temperature, and the microeukaryotic communities displayed a distinct geographical distance-driven pattern. The predominance of the parasitic dinoflagellate lineage Syndiniales and their close relationship with other microeukaryotic groups suggest that parasitism may be a crucial survival strategy for microeukaryotes in the surface waters of the Pacific Ocean. Our findings expand our understanding of the biodiversity and biogeographical pattern of microeukaryotes and highlight the significance of parasitic Syndiniales in the surface ocean.
Effective elimination of bacteria on hard surfaces by the combined use of bacteriophages and chemical disinfectants
Authors: Chen Zongyue , Yang Yuhui , Li Gaoming , Huang Youying , Luo Yu , Le Shuai
Published: April 2024

Hospital-acquired infections (HAIs) represent one of the significant causes of morbidity and mortality worldwide, and controlling pathogens in the hospital environment is of great importance. Currently, the standard disinfection method in the hospital environment is chemical disinfection. However, disinfectants are usually not used strictly according to the label, making them less effective in disinfection. Therefore, there is an emergent need to find a better approach that can be used in hospitals to control pathogenic bacteria in the clinical environment. Bacteriophages (phages) are effective in killing bacteria and have been applied in the treatment of bacterial infections but have not received enough attention regarding the control of contamination in the clinical environment. In this study, we found that various phages remain active in the presence of chemical disinfectants. Moreover, the combined use of specific phages and chemical disinfectants is more effective in removing bacterial biofilms and eliminating bacteria on hard surfaces. Thus, this proof-of-concept study indicates that adding phages directly to chemical disinfectants might be an effective and economical approach to enhance clinical environment disinfection.

IMPORTANCE

In this study, we investigated whether the combination of bacteriophages and chemical disinfectants can enhance the efficacy of reducing bacterial contamination on hard surfaces in the clinical setting. We found that specific phages are active in chemical disinfectants and that the combined use of phages and chemical disinfectants was highly effective in reducing bacterial presence on hard surfaces. As a proof-of-concept, we demonstrated that adding specific phages directly to chemical disinfectants is an effective and cost-efficient strategy for clinical environment disinfection.
Electrochemistry of Molybdenum Single Crystals and Thin Wires in Cyanide and Gold Cyanide Electrolytes
Authors: Palmqvist Ulrik , Leisner Peter , Ahlberg Elisabet
Published: April 2024

Thin wires of molybdenum coated with gold are used for space applications and the adhesion of the gold layer is decisive for their use. The surface morphology of the wires is determined by the manufacturing process and preferential orientation of single crystal surfaces is expected. In this work three different single crystal surfaces were studied together with a 20 μm molybdenum wire to elucidate the importance of surface morphology on the electrodeposition process for gold. Electrochemical impedance spectroscopy was used to study the molybdenum samples in the absence and presence of gold cyanide complexes. The results show large pseudocapacitance prior to gold deposition, indicating the presence of a thin molybdenum oxide film on the surface. Thus, the electrodeposition takes place on the surface oxide and is afflicted with a nucleation overpotential. The overpotential is only slightly dependent on the single crystal orientation, while it is more negative for the wire. The adhesion of gold on the flat single crystal surfaces is weak but marginally better on the wire. This clearly shows that strong chemical binding to the surface is absent and that other processes, such as physical interlocking of the gold layer is necessary for good adhesion.
Biogenic Zinc Oxide Nanoparticles: An Insight into the Advancements in Antimicrobial Resistance
Authors: Sharma Avinash , K. Akash , Kumari Swati , Chauhan Kartik , James Abija , Goel Riya , Singh Jay , Nagraik Rupak , Kumar Deepak
Published: April 2024

Multidrug resistance (MDR) is a significant global challenge requiring strategic solutions to address bacterial infections. Recent advancements in nanotechnology, particularly in the synthesis of zinc oxide nanoparticles (ZnO NPs) using natural agents as stabilizers and reducing agents, have shown promising results in combating MDR. These nanoparticles possess strong antimicrobial properties against different strains of Gram-positive and Gram-negative, making them suitable for various industries, including food, pharmaceuticals, coatings, and medical devices. ZnO-NPs work by generating reactive oxygen species, releasing zinc ions (Zn2+), disrupting the bacterial cell membrane, interfering with metabolic processes and genetic material, and inducing oxidative stress and apoptosis. However, more research is needed to refine synthesis techniques, control size and morphology, and increase antibacterial efficacy. To fully understand their potential, interactions with proteins, DNA, and bacterial cell walls must also be examined. Investigating the synergistic potential of biogenic ZnO NPs with conventional antibacterial treatments could enhance therapeutic effectiveness while minimizing the risk of resistance emergence. Here we provide insight into the advancements in biogenic synthesis of nanoparticles using bio extracts and their applications in antimicrobial resistance as well as various factors affecting the synthesis process and characterization techniques for ZnO NPs. Recent studies on the antimicrobial activity of biogenic ZnO NPs against different pathogens and their mechanisms of action are discussed. Furthermore, potential applications of biogenic ZnO NPs as antimicrobial agents are highlighted.
Review—Unveiling the Power of Deep Learning in Plant Pathology: A Review on Leaf Disease Detection
Authors: Bala Madhu , Bansal Sushil
Published: April 2024

Plant leaf disease identification is a crucial aspect of modern agriculture to enable early disease detection and prevention. Deep learning approaches have demonstrated amazing results in automating this procedure. This paper presents a comparative analysis of various deep learning methods for plant leaf disease identification, with a focus on convolutional neural networks. The performance of these techniques in terms of accuracy, precision, recall, and F1-score, using diverse datasets containing images of diseased leaves from various plant species was examined. This study highlights the strengths and weaknesses of different deep learning approaches, shedding light on their suitability for different plant disease identification scenarios. Additionally, the impact of transfer learning, data augmentation, and sensor data integration in enhancing disease detection accuracy is discussed. The objective of this analysis is to provide valuable insights for researchers and practitioners seeking to harness the potential of deep learning in the agricultural sector, ultimately contributing to more effective and sustainable crop management practices.
Muscle Tone, Stiffness, and Elasticity in Elite Female Cyclists after Consecutive Short Competitions
Authors: Rotllan Cristina , Corbi Francisco , Viscor Ginés
Published: April 2024

Background. For professional road cyclists, most overload injuries affect the lower limbs. They are mostly represented by contractures or muscle shortening, characterised by a variation of muscular tone, stiffness, and elasticity. This real-life study aimed to assess specific mechanical parameters in top-class female cyclists who participated in 3 races a week. Hypothesis. Muscle tone, stiffness, and elasticity will be affected immediately after competition and at the end of the week due to accumulated fatigue. Methods. Six professional cyclists were evaluated. This pilot study consisted of a controlled trial and three days of competition, with rest days between them. MyotonPRO was used to measure tone, stiffness, and elasticity in six leg muscles: vastus lateralis (VL), vastus medialis (VM), rectus femoris (RF), biceps femoris (BF), lateral gastrocnemius (LG), and medial gastrocnemius (MG). Daily basal and pre- and postrace measures were carried through to the 3 races in a week. Results. The muscular tone of VL, VM, LG, and MG and the stiffness of VL, VM, RF, BF, LG, and MG decreased after races. VL and RF were mostly affected by (p=0.05) and (p=0.009), respectively. Basal elasticity improved over time until the last day. Conclusions. Muscle tone and stiffness decreased after a very intense and exhausting cycling endurance competition. Basal elasticity improved immediately after the race and continued this trend until the end of the week. More research is needed on changes in mechanical properties in competition and risk prevention of injuries.
RNA Panel Sequencing Is an Effective Tool to Help Classify Splice Variants for Clinical Oncogenetic Diagnosis
Authors: Privat Maud , Ponelle-Chachuat Flora , Viala Sandrine , Uhrhammer Nancy , Lepage Mathis , Cayre Anne , Bidet Yannick , Bignon Yves-Jean , Gay-Bellile Mathilde , Cavaillé Mathias
Published: April 2024

Routine gene panel analysis identifies pathogenic variants in clinically relevant genes. However, variants of unknown significance (VUSs) are commonly observed, many of which potentially have an impact on mRNA transcription and splicing. Several software programs attempt to predict the impact of variants on splicing and thus make it possible to select the variants for which it is important to study the effect on the transcripts. Transcript analysis is also necessary to show the tandem character of large duplications, and it can be useful for the search for deep intronic variants that are difficult to identify in a DNA panel. We analyzed 53 variants of unknown significance by targeted sequencing of 48 genes using RNA extracted from patient blood samples. RT-PCR and Sanger sequencing of patient mRNA or minigene monoallelic analysis was also carried out when necessary. For the 53 VUSs, 21 could be classified as likely neutral and 10 as pathogenic or likely pathogenic. Data are comprehensively presented for four variants: PTEN c.206+6T>G, MLH1 c.791-489_791-20del, BRCA2 c.68-8_68-7delinsAA, and MSH2 c.(1076+1_1077-1)_(1276+1_1277-1)dup. These four examples illustrate the usefulness of blood RNA panel sequencing in clinical oncogenetics to help classify VUSs with predicted splice effects. It could also be useful for characterizing large duplications and for detecting deep intronic variants with an impact on expressed transcripts.
Cytomegalovirus-Induced Hemophagocytic Lymphohistiocytosis in an Immunocompromised Patient with Inflammatory Bowel Disease
Authors: Pedicelli Alessandro , Michel René P. , Krassakopoulos Nick
Published: April 2024

Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal syndrome of immune hyperactivation, cytokine dysregulation, and severe inflammation. This severe syndrome is commonly triggered by infection, malignancy, autoimmunity, or immunosuppression. We present herein the case of a 56-year-old-female diagnosed with HLH triggered by an acute cytomegalovirus (CMV) infection with viremia in the context of immunosuppression for inflammatory bowel disease. This case highlights the importance of utilizing multiple diagnostic tools, prompt initiation of anti-hemophagocytic treatment, and management of the underlying etiology, to prevent significant morbidity and mortality.
Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature
Authors: Wanberg Lindsey J. , Schultz Brittney , Goyal Amrita
Published: April 2024

Subcorneal pustular dermatosis (SPD) is a rare neutrophilic dermatosis characterized by pustules on the trunk and intertriginous areas. While oral dapsone is the first-line treatment for SPD, alternative options are necessary for patients with glucose-6-phosphate dehydrogenase deficiency, drug hypersensitivity reactions, or refractory disease. To date, no consensus exists regarding next-best agents for SPD. In this report, we present a patient with significant SPD who developed dapsone hypersensitivity syndrome and then was successfully treated with colchicine and adalimumab. We propose that colchicine should be considered as a second-line treatment for SPD and present a therapeutic algorithm for clinicians to utilize when patients are not candidates for dapsone, have side effects requiring drug discontinuation, or have refractory disease.
Supplementary Tables S1-S5 from TAS0313 plus Pembrolizumab for Post-Chemotherapy Immune Checkpoint Inhibitor—Naïve Locally Advanced or Metastatic Urothelial Carcinoma
Authors: Nishiyama Hiroyuki , Yonese Junji , Kawahara Takashi , Matsumoto Ryuji , Miyake Hideaki , Matsubara Nobuaki , Uemura Hiroji , Eto Masatoshi , Azuma Haruhito , Obara Wataru , Terai Akito , Fukasawa Satoshi , Suekane Shigetaka
Published: April 2024

Table S1, Table S2, Table S3, Table S4, Table S5
Supplementary Legends from TAS0313 plus Pembrolizumab for Post-Chemotherapy Immune Checkpoint Inhibitor—Naïve Locally Advanced or Metastatic Urothelial Carcinoma
Authors: Nishiyama Hiroyuki , Yonese Junji , Kawahara Takashi , Matsumoto Ryuji , Miyake Hideaki , Matsubara Nobuaki , Uemura Hiroji , Eto Masatoshi , Azuma Haruhito , Obara Wataru , Terai Akito , Fukasawa Satoshi , Suekane Shigetaka
Published: April 2024

Supplementary Legends
Supplementary Figure S1 from XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
Authors: Patel Ekta , Malkova Natalia V. , Crowe David , Pederzoli-Ribeil Magali , Fantini Damiano , Fanny Manoussa , Madala Hanumantha Rao , Jenkins Kurt A. , Yerov Oleg , Greene Justin , Guzman Wilson , O'Toole Caitlin , Taylor Jacob , O'Donnell Rebekah K. , Johnson Parker , Lanter Bernard B. , Ames Brian , Chen Jia , Vu Sallyann , Wu Hsin-Jung , Cantin Susan , McLaughlin Megan , Hsiao Yu-Shan S. , Tomar Dheeraj S. , Rozenfeld Raphael , Thiruneelakantapillai Lakshmanan , O'Hagan Ronan C. , Nicholson Benjamin , O'Neil Jennifer , Bialucha Carl Uli
Published: April 2024

Supplemental Figure S1: A representative triplex fluorescent western blot image showing cleavage of XTX301 in primary human tumor specimens. Antibodies against human IL-12 (Green), human IL-12Rβ2 (Red) and human IgG (Blue) were used, a merged image is shown in the figure. The 145 Kda band is the intact XTX301 or non-cleavable construct, the 85Kda band is the cleaved XTX301/unmasked construct, the green arrow indicates free IL-12 released upon cleavage of XTX301. The % of cleavage mXT301 refers to the percentage of cleaved molecule compared to the total (intact and cleaved) molecule detected by western blot using the IL-12R2 signal.
Supplementary Table 7 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models
Authors: Pusch Fabian F. , Dorado García Heathcliff , Xu Robin , Gürgen Dennis , Bei Yi , Brückner Lotte , Röefzaad Claudia , von Stebut Jennifer , Bardinet Victor , Chamorro Gonzalez Rocío , Eggert Angelika , Schulte Johannes H. , Hundsdörfer Patrick , Seifert Georg , Haase Kerstin , Schäfer Beat W. , Wachtel Marco , Kühl Anja A. , Ortiz Michael V. , Wengner Antje M. , Scheer Monika , Henssen Anton G.
Published: April 2024

Supplementary Table 7 shows statistical data for the comparison of SoC and elimusertib treatment.
Supplementary Table 6 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models
Authors: Pusch Fabian F. , Dorado García Heathcliff , Xu Robin , Gürgen Dennis , Bei Yi , Brückner Lotte , Röefzaad Claudia , von Stebut Jennifer , Bardinet Victor , Chamorro Gonzalez Rocío , Eggert Angelika , Schulte Johannes H. , Hundsdörfer Patrick , Seifert Georg , Haase Kerstin , Schäfer Beat W. , Wachtel Marco , Kühl Anja A. , Ortiz Michael V. , Wengner Antje M. , Scheer Monika , Henssen Anton G.
Published: April 2024

Supplementary Table 6 lists the quantifications of IHC markers in NB PDX.
Figure S6 from Multiomic-Based Molecular Landscape of FaDu Xenograft Tumors in Mice after a Combinatorial Treatment with Radiation and an HSP90 Inhibitor Identifies Adaptation-Induced Targets of Resistance and Therapeutic Intervention
Authors: Bylicky Michelle A. , Shankavaram Uma , Aryankalayil Molykutty J. , Chopra Sunita , Naz Sarwat , Sowers Anastasia L. , Choudhuri Rajani , Calvert Valerie , Petricoin Emanuel F. , Eke Iris , Mitchell James B. , Coleman C. Norman
Published: April 2024

Supplemental Figure S6: Graphs of proteins and phosphoproteins that previously showed impact on cancer proliferation or death. Trends towards significance only. Normalized to intensity. For JUN, microarray data showed that Drug Week 2 and Drug+Rad Week 1 were significantly decreased ([FC} > 2, p < 0.05) compared to respective Untreated tumors.
Supplementary Table 2 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models
Authors: Pusch Fabian F. , Dorado García Heathcliff , Xu Robin , Gürgen Dennis , Bei Yi , Brückner Lotte , Röefzaad Claudia , von Stebut Jennifer , Bardinet Victor , Chamorro Gonzalez Rocío , Eggert Angelika , Schulte Johannes H. , Hundsdörfer Patrick , Seifert Georg , Haase Kerstin , Schäfer Beat W. , Wachtel Marco , Kühl Anja A. , Ortiz Michael V. , Wengner Antje M. , Scheer Monika , Henssen Anton G.
Published: April 2024

Supplementary Table 2 lists characteristics of PDX origin.
Figure S5 from Multiomic-Based Molecular Landscape of FaDu Xenograft Tumors in Mice after a Combinatorial Treatment with Radiation and an HSP90 Inhibitor Identifies Adaptation-Induced Targets of Resistance and Therapeutic Intervention
Authors: Bylicky Michelle A. , Shankavaram Uma , Aryankalayil Molykutty J. , Chopra Sunita , Naz Sarwat , Sowers Anastasia L. , Choudhuri Rajani , Calvert Valerie , Petricoin Emanuel F. , Eke Iris , Mitchell James B. , Coleman C. Norman
Published: April 2024

Supplemental Figure S5. Proteomic and Phospho-proteomic comparison of changes observed comparing UT_Wk1 to UT_Wk2 (A), Treated Week 1 to UT_Wk1 (B) and Treated Week 2 to UT_Wk2 (C). Trends towards significance only. Normalized to intensity. No notable change is shown in white, upregulation is red, downregulation is blue. Supplemental Figure 4A indicates change in UT_Wk2 compared to UT_Wk1, interestingly p53 and PDL-1 protein expression decrease over three days. Supplemental Figure 6A indicates change in Untreated Week 2 compared to Untreated Week 1, interestingly p53 and PDL-1 protein expression show a decreasing trend.
Figure S3 from Multiomic-Based Molecular Landscape of FaDu Xenograft Tumors in Mice after a Combinatorial Treatment with Radiation and an HSP90 Inhibitor Identifies Adaptation-Induced Targets of Resistance and Therapeutic Intervention
Authors: Bylicky Michelle A. , Shankavaram Uma , Aryankalayil Molykutty J. , Chopra Sunita , Naz Sarwat , Sowers Anastasia L. , Choudhuri Rajani , Calvert Valerie , Petricoin Emanuel F. , Eke Iris , Mitchell James B. , Coleman C. Norman
Published: April 2024

Supplemental Figure S3: IPA pathway highlights genes relevant to, Cell Migration, Angiogenesis and Morbidity or mortality for Treatment groups at Week 2 compared to Untreated Week 2. Significantly altered genes ([2-fold change, p < 0.01) are shown. White indicates no significant changes, Red indicates upregulation, Blue indicates downregulation. Black arrows indicate genes of interest. More genes exist in these pathways than are displayed, for ease of visualization only genes which showed significant changes in expression in at least 2 treatment groups are presented. Genes may be relevant to more than one pathway (PLAUR) is relevant to Organismal Death and Vasculogenesis, but to avoid redundancy is shown once.
Figure S2 from Multiomic-Based Molecular Landscape of FaDu Xenograft Tumors in Mice after a Combinatorial Treatment with Radiation and an HSP90 Inhibitor Identifies Adaptation-Induced Targets of Resistance and Therapeutic Intervention
Authors: Bylicky Michelle A. , Shankavaram Uma , Aryankalayil Molykutty J. , Chopra Sunita , Naz Sarwat , Sowers Anastasia L. , Choudhuri Rajani , Calvert Valerie , Petricoin Emanuel F. , Eke Iris , Mitchell James B. , Coleman C. Norman
Published: April 2024

Supplemental Figure S2: IPA pathway highlights genes relevant to Organismal Death, Viral Infection and Vasculogenesis for Treatment groups at Week 1 compared to Control Day 1. Significantly altered genes (2-fold change, p < 0.01) are shown. White indicates no significant change, Red indicates upregulation, Blue indicates downregulation. Black arrows indicate genes of interest. Drug+Rad and Drug alone caused significantly more gene up/down regulation than Rad alone. More genes exist in these pathways than are displayed, for ease of visualization only genes which showed significant changes in expression in at least 2 treatment groups are presented. Genes may be relevant to more than one pathway (PLAUR) is relevant to Organismal Death and Vasculogenesis, but to avoid redundancy is shown once.
Figure S1 from Multiomic-Based Molecular Landscape of FaDu Xenograft Tumors in Mice after a Combinatorial Treatment with Radiation and an HSP90 Inhibitor Identifies Adaptation-Induced Targets of Resistance and Therapeutic Intervention
Authors: Bylicky Michelle A. , Shankavaram Uma , Aryankalayil Molykutty J. , Chopra Sunita , Naz Sarwat , Sowers Anastasia L. , Choudhuri Rajani , Calvert Valerie , Petricoin Emanuel F. , Eke Iris , Mitchell James B. , Coleman C. Norman
Published: April 2024

Supplemental Figure S1: IPA pathway highlights genes relevant to Organismal Death, Viral infection and Vasculogenesis for Untreated groups at Week 1 and Week 2 compared to Control Day 1. Significantly altered genes (2-fold change, p < 0.01) are shown. White indicates no significant change, Red indicates upregulation, Blue indicates downregulation. Black arrows indicate genes of interest.
Supplementary Figure 4 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models
Authors: Pusch Fabian F. , Dorado García Heathcliff , Xu Robin , Gürgen Dennis , Bei Yi , Brückner Lotte , Röefzaad Claudia , von Stebut Jennifer , Bardinet Victor , Chamorro Gonzalez Rocío , Eggert Angelika , Schulte Johannes H. , Hundsdörfer Patrick , Seifert Georg , Haase Kerstin , Schäfer Beat W. , Wachtel Marco , Kühl Anja A. , Ortiz Michael V. , Wengner Antje M. , Scheer Monika , Henssen Anton G.
Published: April 2024

Supplementary Figure 4 shows immunofluorescence stainings of R-loops and their quanitfication in pediatric cancer cell lines.
Supplementary Figure 3 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models
Authors: Pusch Fabian F. , Dorado García Heathcliff , Xu Robin , Gürgen Dennis , Bei Yi , Brückner Lotte , Röefzaad Claudia , von Stebut Jennifer , Bardinet Victor , Chamorro Gonzalez Rocío , Eggert Angelika , Schulte Johannes H. , Hundsdörfer Patrick , Seifert Georg , Haase Kerstin , Schäfer Beat W. , Wachtel Marco , Kühl Anja A. , Ortiz Michael V. , Wengner Antje M. , Scheer Monika , Henssen Anton G.
Published: April 2024

Supplementary Figure 3 shows western blots of DNA damage response markers in two pediatric cancer cell lines.
Supplementary Figure 12 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models
Authors: Pusch Fabian F. , Dorado García Heathcliff , Xu Robin , Gürgen Dennis , Bei Yi , Brückner Lotte , Röefzaad Claudia , von Stebut Jennifer , Bardinet Victor , Chamorro Gonzalez Rocío , Eggert Angelika , Schulte Johannes H. , Hundsdörfer Patrick , Seifert Georg , Haase Kerstin , Schäfer Beat W. , Wachtel Marco , Kühl Anja A. , Ortiz Michael V. , Wengner Antje M. , Scheer Monika , Henssen Anton G.
Published: April 2024

Supplementary Figure 12 shows changes in pHH3, yH2AX and Clc3 expression in PDXs of different entities.
Supplementary Table S7 from Combination Therapy with EGFR Tyrosine Kinase Inhibitors and TEAD Inhibitor Increases Tumor Suppression Effects in EGFR Mutation–positive Lung Cancer
Authors: Ogimoto Tatsuya , Ozasa Hiroaki , Tsuji Takahiro , Funazo Tomoko , Yamazoe Masatoshi , Hashimoto Kentaro , Yoshida Hiroshi , Hosoya Kazutaka , Ajimizu Hitomi , Nomizo Takashi , Yoshida Hironori , Hamaji Masatsugu , Menju Toshi , Yoshizawa Akihiko , Date Hiroshi , Hirai Toyohiro
Published: April 2024

Supplementary Table S7 shows patient characteristics.
Supplementary Table S5 from Combination Therapy with EGFR Tyrosine Kinase Inhibitors and TEAD Inhibitor Increases Tumor Suppression Effects in EGFR Mutation–positive Lung Cancer
Authors: Ogimoto Tatsuya , Ozasa Hiroaki , Tsuji Takahiro , Funazo Tomoko , Yamazoe Masatoshi , Hashimoto Kentaro , Yoshida Hiroshi , Hosoya Kazutaka , Ajimizu Hitomi , Nomizo Takashi , Yoshida Hironori , Hamaji Masatsugu , Menju Toshi , Yoshizawa Akihiko , Date Hiroshi , Hirai Toyohiro
Published: April 2024

Supplementary Table S5 shows antibodies used for immunohistochemical staining.
Supplementary Table S3 from Combination Therapy with EGFR Tyrosine Kinase Inhibitors and TEAD Inhibitor Increases Tumor Suppression Effects in EGFR Mutation–positive Lung Cancer
Authors: Ogimoto Tatsuya , Ozasa Hiroaki , Tsuji Takahiro , Funazo Tomoko , Yamazoe Masatoshi , Hashimoto Kentaro , Yoshida Hiroshi , Hosoya Kazutaka , Ajimizu Hitomi , Nomizo Takashi , Yoshida Hironori , Hamaji Masatsugu , Menju Toshi , Yoshizawa Akihiko , Date Hiroshi , Hirai Toyohiro
Published: April 2024

Supplementary Table S3 shows primers used for qRT-PCR.
Supplementary Figure S5 from Combination Therapy with EGFR Tyrosine Kinase Inhibitors and TEAD Inhibitor Increases Tumor Suppression Effects in EGFR Mutation–positive Lung Cancer
Authors: Ogimoto Tatsuya , Ozasa Hiroaki , Tsuji Takahiro , Funazo Tomoko , Yamazoe Masatoshi , Hashimoto Kentaro , Yoshida Hiroshi , Hosoya Kazutaka , Ajimizu Hitomi , Nomizo Takashi , Yoshida Hironori , Hamaji Masatsugu , Menju Toshi , Yoshizawa Akihiko , Date Hiroshi , Hirai Toyohiro
Published: April 2024

Supplementary Figure S5 shows the relative expression of CYR61 in KTOR27 cells treated with afatinib with or without VT104.
Supplementary Figure S2 from Combination Therapy with EGFR Tyrosine Kinase Inhibitors and TEAD Inhibitor Increases Tumor Suppression Effects in EGFR Mutation–positive Lung Cancer
Authors: Ogimoto Tatsuya , Ozasa Hiroaki , Tsuji Takahiro , Funazo Tomoko , Yamazoe Masatoshi , Hashimoto Kentaro , Yoshida Hiroshi , Hosoya Kazutaka , Ajimizu Hitomi , Nomizo Takashi , Yoshida Hironori , Hamaji Masatsugu , Menju Toshi , Yoshizawa Akihiko , Date Hiroshi , Hirai Toyohiro
Published: April 2024

Supplementary Figure S2 shows cell viability assays of KTOR27 cells treated with VT103 or VT104.
Supplementary Data S1 from Combination Therapy with EGFR Tyrosine Kinase Inhibitors and TEAD Inhibitor Increases Tumor Suppression Effects in EGFR Mutation–positive Lung Cancer
Authors: Ogimoto Tatsuya , Ozasa Hiroaki , Tsuji Takahiro , Funazo Tomoko , Yamazoe Masatoshi , Hashimoto Kentaro , Yoshida Hiroshi , Hosoya Kazutaka , Ajimizu Hitomi , Nomizo Takashi , Yoshida Hironori , Hamaji Masatsugu , Menju Toshi , Yoshizawa Akihiko , Date Hiroshi , Hirai Toyohiro
Published: April 2024

Supplementary Data S1 shows the list of compound names and relative cell viability rates.
Supplementary Table 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis
Authors: Pichavaram Prahalathan , Jablonowski Carolyn M. , Fang Jie , Fleming Andrew M. , Gil Hyea Jin , Boghossian Andrew S. , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Morton Christopher L. , Zambetti Gerard P. , Davidoff Andrew M. , Yang Jun , Murphy Andrew J.
Published: April 2024

PCR primers used in the current study
Supplementary Table 1 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis
Authors: Pichavaram Prahalathan , Jablonowski Carolyn M. , Fang Jie , Fleming Andrew M. , Gil Hyea Jin , Boghossian Andrew S. , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Morton Christopher L. , Zambetti Gerard P. , Davidoff Andrew M. , Yang Jun , Murphy Andrew J.
Published: April 2024

Antibodies used in the current study
Figure S6 from ADCT-602, a Novel PBD Dimer–containing Antibody–Drug Conjugate for Treating CD22-positive Hematologic Malignancies
Authors: Zammarchi Francesca , Havenith Karin E. , Sachini Nikoleta , Janghra Narinder , Chivers Simon , Idusogie Esohe , Gaudio Eugenio , Tarantelli Chiara , Bertelli Francois , Santos Kathleen , Tyrer Peter , Corbett Simon , Spriano Filippo , Golino Gaetanina , Cascione Luciano , Bertoni Francesco , Hartley John A. , van Berkel Patrick H.
Published: April 2024

Supplementary Fig. S6. Group mean body weight of mice in (A) Ramos, (B) WSU-DLCL2, (C) REH, and (D) KARPAS-299 efficacy studies. Data shown as mean body weight (g) ± SEM over time (for each group, n = 10 in A-B, and n = 8 in C-D). QD once daily; Q4D once every 4 days; SEM standard error of mean.
Supplementary Figure 7 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis
Authors: Pichavaram Prahalathan , Jablonowski Carolyn M. , Fang Jie , Fleming Andrew M. , Gil Hyea Jin , Boghossian Andrew S. , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Morton Christopher L. , Zambetti Gerard P. , Davidoff Andrew M. , Yang Jun , Murphy Andrew J.
Published: April 2024

QC6352 treatment (25nM x 72 hours) reduces nucleoli in WiT49 and HEK293. (A) KDM4A (red) and the nucleolar marker fibrillarin (green) co-localize in the nucleoli [also represented by areas of reduced DAPI staining (blue) in the nucleus due to incompact chromatin in nucleoli] in WiT49 cells. (B) QC6352 treatment caused a reduction in the fibrillarin/nuclear area (determined by the area of fibrillarin/area DAPI) in WiT49 cells (p<0.0001), representing a reduction of nucleoli. (C) Similar findings were found in QC6352-treated HEK293 cells, which also exhibited a (D) reduction of the fibrillarin/nuclear area (p<0.0001).
Figure S4 from ADCT-602, a Novel PBD Dimer–containing Antibody–Drug Conjugate for Treating CD22-positive Hematologic Malignancies
Authors: Zammarchi Francesca , Havenith Karin E. , Sachini Nikoleta , Janghra Narinder , Chivers Simon , Idusogie Esohe , Gaudio Eugenio , Tarantelli Chiara , Bertelli Francois , Santos Kathleen , Tyrer Peter , Corbett Simon , Spriano Filippo , Golino Gaetanina , Cascione Luciano , Bertoni Francesco , Hartley John A. , van Berkel Patrick H.
Published: April 2024

Supplementary Fig. S4. Time course of DNA ICL formation in KARPAS-299 cells following a 2-hour treatment with ADCT-602 or SG3199. Results are presented as a mean percentage decrease in OTM ± SD (n = 4). ICL interstrand crosslinking; OTM Olive tail moment.
Supplementary Figure 5 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis
Authors: Pichavaram Prahalathan , Jablonowski Carolyn M. , Fang Jie , Fleming Andrew M. , Gil Hyea Jin , Boghossian Andrew S. , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Morton Christopher L. , Zambetti Gerard P. , Davidoff Andrew M. , Yang Jun , Murphy Andrew J.
Published: April 2024

Gene set enrichment analysis demonstrated significant downregulation of the REACTOME_EUKARYOTIC_TRANSLATION_INITIATION and REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA pathways in QC6352-treated WiT49 cells and the REACTOME_EUKARYOTIC_TRANSLATION_INITIATION pathway in HEK293 cells.
Figure S2 from ADCT-602, a Novel PBD Dimer–containing Antibody–Drug Conjugate for Treating CD22-positive Hematologic Malignancies
Authors: Zammarchi Francesca , Havenith Karin E. , Sachini Nikoleta , Janghra Narinder , Chivers Simon , Idusogie Esohe , Gaudio Eugenio , Tarantelli Chiara , Bertelli Francois , Santos Kathleen , Tyrer Peter , Corbett Simon , Spriano Filippo , Golino Gaetanina , Cascione Luciano , Bertoni Francesco , Hartley John A. , van Berkel Patrick H.
Published: April 2024

Supplementary Fig. S2. The in vitro antitumor activity of ADCT-602 does not correlate with CD22 levels in B-cell lymphomas. This figure shows a correlation of ADCT-602 IC50 values versus (A) cell surface protein expression via absolute fluorescence quantitation with Quantum Simply Cellular microspheres, (B) CD22 RNA expression levels measured via Illumina HT-12 microarrays, and (C) targeted RNA-Seq with the HTG EdgeSeq Oncology Biomarker Panel. On each plot, the x-axes are the ADCT-602 IC50 values presented as log2, and the y-axes are CD22 expression levels presented as log2. Cell lines derived from Hodgkin and T-cell lymphomas have been excluded. IC50 50% inhibitory concentration.
Supplementary Figure 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis
Authors: Pichavaram Prahalathan , Jablonowski Carolyn M. , Fang Jie , Fleming Andrew M. , Gil Hyea Jin , Boghossian Andrew S. , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Morton Christopher L. , Zambetti Gerard P. , Davidoff Andrew M. , Yang Jun , Murphy Andrew J.
Published: April 2024

QC6352 treatment does not result in decreased cell viability or growth as determined by crystal violet assay in the anaplastic Wilms tumor cell line 17.94, or the favorable histology Wilms tumor cell lines PDM182 and COG-W-408.
Supplementary Figure 17 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis
Authors: Pichavaram Prahalathan , Jablonowski Carolyn M. , Fang Jie , Fleming Andrew M. , Gil Hyea Jin , Boghossian Andrew S. , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Morton Christopher L. , Zambetti Gerard P. , Davidoff Andrew M. , Yang Jun , Murphy Andrew J.
Published: April 2024

(A) Log2CPM RNA-seq values demonstrate that KDM4A transcription and protein levels are not directly correlated and that high KDM4A expression by RNA-seq does not positively correlate with sensitivity to QC6352. (B) QC6352 treatment did not alter protein levels of KDM4A, B, or C in COG-W-408, PDM182, or 17.94 cells, all of which are insensitive to QC6352.
Table S3 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Authors: Bennett Lynda , Jaiswal Praveen Kumar , Harkless Ryan V. , Long Tiha M. , Gao Ning , Vandenburg Brianna , Selman Phillip , Durdana Ishrat , Lastra Ricardo R. , Vander Griend Donald , Adelaiye-Ogala Remi , Szmulewitz Russell Z. , Conzen Suzanne D.
Published: April 2024

List of cAMP pathway genes n=224 (based on IPA) used in this study
Figure S5 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Authors: Bennett Lynda , Jaiswal Praveen Kumar , Harkless Ryan V. , Long Tiha M. , Gao Ning , Vandenburg Brianna , Selman Phillip , Durdana Ishrat , Lastra Ricardo R. , Vander Griend Donald , Adelaiye-Ogala Remi , Szmulewitz Russell Z. , Conzen Suzanne D.
Published: April 2024

Cyclic AMP pathway expression in GR high vs GR low mCRPC and PDX models
Figure S4 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Authors: Bennett Lynda , Jaiswal Praveen Kumar , Harkless Ryan V. , Long Tiha M. , Gao Ning , Vandenburg Brianna , Selman Phillip , Durdana Ishrat , Lastra Ricardo R. , Vander Griend Donald , Adelaiye-Ogala Remi , Szmulewitz Russell Z. , Conzen Suzanne D.
Published: April 2024

A downstream cAMP-activated transcription factor, CREB, is phosphorylated at Ser133 following GR activation
Figure S2 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Authors: Bennett Lynda , Jaiswal Praveen Kumar , Harkless Ryan V. , Long Tiha M. , Gao Ning , Vandenburg Brianna , Selman Phillip , Durdana Ishrat , Lastra Ricardo R. , Vander Griend Donald , Adelaiye-Ogala Remi , Szmulewitz Russell Z. , Conzen Suzanne D.
Published: April 2024

GR activation increases PKA substrate phosphorylation events in AR-antagonized CWR-22Rv1 cells
Supplementary Table S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth
Authors: Begovich Kyle , Schoolmeesters Angela , Rajapakse Navin , Martinez-Terroba Elena , Kumar Maneesh , Shakya Arvind , Lai Chon , Greene Steven , Whitefield Brandon , Okano Akinori , Mali Venkat , Huang Shenlin , Chourasia Aparajita H. , Fung Leah
Published: April 2024

Supplementary Table S5 shows the IC50 values for SOS1 inhibitors in 3D proliferation assays for KRAS G12D cell lines
Supplementary Table S3 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth
Authors: Begovich Kyle , Schoolmeesters Angela , Rajapakse Navin , Martinez-Terroba Elena , Kumar Maneesh , Shakya Arvind , Lai Chon , Greene Steven , Whitefield Brandon , Okano Akinori , Mali Venkat , Huang Shenlin , Chourasia Aparajita H. , Fung Leah
Published: April 2024

Supplementary Table S3 lists the EC50 and IC50 values for ternary complex formation and SOS1 binding for compounds used in this study
Supplementary Table S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth
Authors: Begovich Kyle , Schoolmeesters Angela , Rajapakse Navin , Martinez-Terroba Elena , Kumar Maneesh , Shakya Arvind , Lai Chon , Greene Steven , Whitefield Brandon , Okano Akinori , Mali Venkat , Huang Shenlin , Chourasia Aparajita H. , Fung Leah
Published: April 2024

Supplementary Table 2 lists all the antibodies used in this study for Western Blot experiments
Supplementary Table S2 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Authors: Lulla Amriti R. , Akli Said , Karakas Cansu , Caruso Joseph A. , Warma Lucas D. , Fowlkes Natalie W. , Rao Xiayu , Wang Jing , Hunt Kelly K. , Watowich Stephanie S. , Keyomarsi Khandan
Published: April 2024

Multivariate Cox Proportional Hazards Analysis of Clinicopathologic Variables’ Influence in Breast Cancer RFS (n=242)
Figure S5 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Authors: Lulla Amriti R. , Akli Said , Karakas Cansu , Caruso Joseph A. , Warma Lucas D. , Fowlkes Natalie W. , Rao Xiayu , Wang Jing , Hunt Kelly K. , Watowich Stephanie S. , Keyomarsi Khandan
Published: April 2024

Supplementary Figure S5: Reverse Phase Protein Array (RPPA) analysis was conducted on TAN negative and TAN positive patient samples described in Figure 1, using 174 validated antibodies. The mean of the normalized, linear RPPA values are reported for each group. (A) Relative abundance of pp90RSK T359/S363 and pRb S807 in TAN negative and TAN positive patient samples. (B) The table summarizes the top 20 antibodies that were statistically altered between the TAN negative and TAN positive groups. Statistical comparisons of TAN-positive and TAN-negative cohorts were performed using the Mann-Whitney U-test.
Table S9 from Development of a Novel DNA Mono-alkylator Platform for Antibody–Drug Conjugates
Authors: Thomas Joshua D. , Yurkovetskiy Aleksandr V. , Yin Mao , Bodyak Natalya D. , Tang Shuyi , Protopopova Marina , Kelleher Eugene , Jones Brian , Yang Liping , Custar Daniel , Catcott Kalli C. , Demady Damon R. , Collins Scott D. , Xu Ling , Bu Charlie , Qin LiuLiang , Ter-Ovanesyan Elena , Damelin Marc , Toader Dorin , Lowinger Timothy B.
Published: April 2024

Table shows Cytotoxicity Data for Platforms 18 vs 19
Supplemental Table S7 from The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors
Authors: Robey Robert W. , Fitzsimmons Christina M. , Guiblet Wilfried M. , Frye William J.E. , González Dalmasy José M. , Wang Li , Russell Drake A. , Huff Lyn M. , Perciaccante Andrew J. , Ali-Rahmani Fatima , Lipsey Crystal C. , Wade Heidi M. , Mitchell Allison V. , Maligireddy Siddhardha S. , Terrero David , Butcher Donna , Edmondson Elijah F. , Jenkins Lisa M. , Nikitina Tatiana , Zhurkin Victor B. , Tiwari Amit K. , Piscopio Anthony D. , Totah Rheem A. , Bates Susan E. , Arda H. Efsun , Gottesman Michael M. , Batista Pedro J.
Published: April 2024

Supplemental Table S7 contains information about the normal tissue expression of METTL7A and METTL7B
Table S8 from Development of a Novel DNA Mono-alkylator Platform for Antibody–Drug Conjugates
Authors: Thomas Joshua D. , Yurkovetskiy Aleksandr V. , Yin Mao , Bodyak Natalya D. , Tang Shuyi , Protopopova Marina , Kelleher Eugene , Jones Brian , Yang Liping , Custar Daniel , Catcott Kalli C. , Demady Damon R. , Collins Scott D. , Xu Ling , Bu Charlie , Qin LiuLiang , Ter-Ovanesyan Elena , Damelin Marc , Toader Dorin , Lowinger Timothy B.
Published: April 2024

Table shows Tabulated cell growth inhibition data for NCI-N87 and MDA-MB231 cells in monoculture and coculture when treated with ADCs T-16, T-17, and T-18
Supplemental Table S2 from The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors
Authors: Robey Robert W. , Fitzsimmons Christina M. , Guiblet Wilfried M. , Frye William J.E. , González Dalmasy José M. , Wang Li , Russell Drake A. , Huff Lyn M. , Perciaccante Andrew J. , Ali-Rahmani Fatima , Lipsey Crystal C. , Wade Heidi M. , Mitchell Allison V. , Maligireddy Siddhardha S. , Terrero David , Butcher Donna , Edmondson Elijah F. , Jenkins Lisa M. , Nikitina Tatiana , Zhurkin Victor B. , Tiwari Amit K. , Piscopio Anthony D. , Totah Rheem A. , Bates Susan E. , Arda H. Efsun , Gottesman Michael M. , Batista Pedro J.
Published: April 2024

Supplemental Table S2 contains information about the cross-resistance profile of MCF7 DpVp300 cells for multiple drugs
Supplementary Data from Development of a Novel DNA Mono-alkylator Platform for Antibody–Drug Conjugates
Authors: Thomas Joshua D. , Yurkovetskiy Aleksandr V. , Yin Mao , Bodyak Natalya D. , Tang Shuyi , Protopopova Marina , Kelleher Eugene , Jones Brian , Yang Liping , Custar Daniel , Catcott Kalli C. , Demady Damon R. , Collins Scott D. , Xu Ling , Bu Charlie , Qin LiuLiang , Ter-Ovanesyan Elena , Damelin Marc , Toader Dorin , Lowinger Timothy B.
Published: April 2024

Supplementary Materials and Methods including Assays and Synthetic Procedures