bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating the performances of a flexible mechanism of water diversion: application on a northern Italy gravity-driven irrigation channel
Authors: Masseroni Daniele , Castagna Alessandro , Gandolfi Claudio
Published: February 2021

Improving the management of irrigation schemes is a priority in the Mediterranean countries of the EU to achieve the objectives of the Water Framework Directive 2000/60EC. In the case of schemes based on open-channel networks for water conveyance and delivery, a limitation to the management efficiency is the huge number of gates that need to be controlled and regulated manually to adapt the flow to the actual irrigation water demand. Automated and coordinated gate regulation of large irrigation schemes has been successfully implemented in some areas of the world (e.g., NSW, Australia), but it implies huge public investments that are often unavailable. Opposite to this top–down approach, the Lombardy region (the largest irrigated region in the EU) has explored an approach based on funding small projects, which should demonstrate the potential of innovation in irrigation practice and foster the expansion of the most effective measures. In this paper, we analyze the effects of one of these projects, consisting in the substitution of a manual gate, controlling the supply of irrigation to a 150 ha irrigation district, with an automated, remotely controlled gate. Nine years of daily flow measurements at the district inlet, provided by the irrigation consortium that manages the gate, were compared with the rigid flow regulation that was applied when the inlet gate was manually regulated and with the irrigation water requirements simulated with a distributed agro-hydrological model widely used in the region for irrigation accounting and planning. The results show that the flexible regulation allowed by the new gate provided an average water saving of 12,000 m3/ha/year compared to the rigid regulation system. A further, though smaller, margin of improvement of 5000 m3/ha/year can be achieved with an optimal regulation that follows exactly the crop water requirements. A further interesting empirical evidence is that the simulation model fits very well the irrigation water requirements of the district using only easily accessible meteorological input data, without exploiting any information from ground or remote sensors to update soil moisture or crop developments during the season. This indicates that it could be effectively used, with very limited costs and effort, to support and improve the gate management. Finally, a preliminary economic analysis shows that the cost of the gate installation is sustainable, but the upscaling of this type of intervention to larger areas requires the support of public funding to cover approximately half of the cost of investment needed for the networking infrastructures.
Intraokulare Entzündungen bei Brolucizumab-Anwendung
Authors: Holz F. G. , Heinz C. , Wolf A. , Hoerauf H. , Pleyer U.
Published: February 2021

Der VEGF(„vascular endothelial growth factor“)-Inhibitor Brolucizumab ist seit Oktober 2019 in den USA und seit Februar 2020 in Europa zur Behandlung der neovaskulären altersabhängigen Makuladegeneration (nAMD) zugelassen. Grundlage der Zulassung bildeten die randomisierten, doppel-blinden Phase-III-Studien HAWK und HARRIER mit insgesamt 1817 Patienten. Hierbei zeigte Brolucizumab 6 mg (je nach Krankheitsaktivität alle 12 oder alle 8 Wochen verabreicht) eine nichtunterlegene Wirksamkeit in Bezug auf den bestkorrigierten Visus gegenüber Aflibercept 2 mg (alle 8 Wochen verabreicht). Erste Rückmeldungen zum Einsatz von Brolucizumab nach der Marktzulassung in den USA haben einzelne, z. T. schwerwiegende Fälle behandlungsassoziierter intraokularer Entzündungen mit retinaler Vaskulitis und/oder retinaler, vaskulärer Okklusion beschrieben, die teilweise zu einem schweren Visusverlust führten. Die Daten der Zulassungsstudien wurden daraufhin durch ein Safety Review Committee (SRC) unabhängig retrospektiv analysiert. Ziel der vorliegenden Publikation ist es, Anwendern eine Orientierungshilfe aus Autorensicht bei der Therapie einer Brolucizumab-assoziierten intraokularen Entzündung zu bieten. Von zentraler Bedeutung ist hierbei auch eine erweiterte Aufklärung der Patienten über Symptome einer intraokularen Entzündung. Obwohl die Fallserien und die HAWK/HARRIER-Daten es nicht abschließend beantworten, bleiben eine zu späte Detektion, eine unterdosierte antientzündliche Therapie oder eine unbedachte Wiederbehandlung mit Brolucizumab dem Verdacht ausgesetzt, Komplikationen zu verstärken. Ein Stopp der Brolucizumab-Therapie sollte grundsätzlich erfolgen, sobald es nach Gabe des Medikaments zu intraokularen Entzündungen mit oder ohne retinalen Vaskulitiden und oder Gefäßverschluss kam. Abhängig vom Schwerpunkt der Entzündung werden dem Behandler an die Leitlinien und Stellungnahmen angelehnte Empfehlungen für Diagnostik und Therapie dargestellt. Diese Übersichtsarbeit ersetzt nicht die fachgesellschaftlichen Stellungnahmen.
Pseudotumor cerebri syndrome in a child with Alagille syndrome: intracranial pressure dynamics and treatment outcome after ventriculoperitoneal shunting
Authors: Polemikos Manolis , Hermann Elvis J. , Heissler Hans E. , Hartmann Hans , Krauss Joachim K.
Published: February 2021

Alagille syndrome (AS) is a rare multisystem disease of the liver, heart, eyes, face, skeleton, kidneys, and vascular system. The occurrence of pseudotumor cerebri syndrome (PTCS) in patients with AS has been reported only exceptionally. Owning to its rarity and a mostly atypical presentation, the diagnosis and natural history of affected patients remain uncertain. We report an atypical case of PTCS in a 4-year-old boy with a known history of AS who presented with bilateral papilledema (PE) on a routine ophthalmological examination. Visual findings deteriorated after treatment with acetazolamide. Continuous intracranial pressure (ICP) monitoring was then utilized to investigate ICP dynamics. Successful treatment with resolution of PE was achieved after ventriculoperitoneal shunting but relapsed due to growth-related dislocation of the ventricular catheter. This report brings new insights into the ICP dynamics and the resulting treatment in this possibly underdiagnosed subgroup of PTCS patients. It also demonstrates that ventriculoperitoneal shunting can provide long-term improvement of symptoms for more than 10 years.
Historical and future climates over the upper and middle reaches of the Yellow River Basin simulated by a regional climate model in CORDEX
Authors: Wang Xuejia , Chen Deliang , Pang Guojin , Gou Xiaohua , Yang Meixue
Published: February 2021

Despite the importance of the Yellow River to China, climate change for the middle reaches of the Yellow River Basin (YRB) has been investigated far less than for other regions. This work focuses on future changes in mean and extreme climate of the YRB for the near-term (2021–2040), mid-term (2041–2060), and far-term (2081–2100) future, and assesses these with respect to the reference period (1986–2005) using the latest REgional MOdel (REMO) simulations, driven by three global climate models (GCMs) and assuming historical and future [Representative Concentration Pathway (RCP) 2.6 and 8.5] forcing scenarios, over the CORDEX East Asia domain at 0.22° horizontal resolution. The results show that REMO reproduces the historical mean climate state and selected extreme climate indices reasonably well, although some cold and wet biases exist. Increases in mean temperature are strongest for the far-term in winter, with an average increase of 5.6 °C under RCP 8.5. As expected, the future temperatures of the warmest day (TXx) and coldest night (TNn) increase and the number of frost days (FD) declines considerably. Changes to mean temperature and FD depend on elevation, which could be explained by the snow-albedo feedback. A substantial increase in precipitation (34%) occurs in winter under RCP 8.5 for the far-term. Interannual variability in precipitation is projected to increase, indicating a future climate with more extreme events compared to that of today. Future daily precipitation intensity and maximum 5-day precipitation would increase and the number of consecutive dry days would decline under RCP 8.5. The results highlight that pronounced warming at high altitudes and more intense rainfall could cause increased future flood risk in the YRB, if a high GHG emission pathway is realized.
Thoracoscopic oesophageal atresia/tracheo-oesophageal fistula (OA/TOF) repair is associated with a higher stricture rate: a single institution’s experience
Authors: Thakkar H. , Mullassery D. M. , Giuliani S. , Blackburn S. , Cross K. , Curry J. , De Coppi Paolo
Published: February 2021

Purpose

Thoracoscopic OA/TOF repair was first described in 1999. Currently, less than 10% of surgeons routinely employ minimally access surgery. Our primary aim was to review our immediate-, early- and long-term outcomes with this technique compared with the open approach.

Methods

A retrospective review of all patients undergoing primary OA/TOF (Type C) repair at our institution from 2009 was conducted. Outcome measures included length of surgery, conversion rate from thoracoscopy, early complications such as anastomotic leak and post-operative complications such as anastomotic strictures needing dilatations. Fisher’s exact and Kruskal–Wallis tests were used for statistical analysis.

Results

95 patients in total underwent OA/TOF repair during the study period of which 61 (64%) were completed via an open approach. 34 were attempted thoracoscopically of which 11 (33%) were converted. There was only one clinically significant anastomotic leak in our series that took place in the thoracoscopic group. We identified a significantly higher stricture rate in our thoracoscopic cohort (72%) versus open surgery (43%, P < 0.05). However, the median number of dilations (3) performed was not significantly different between the groups. There was one recurrent fistula in the thoracoscopic converted to open group. Our median follow-up was 60 months across the groups.

Conclusion

In our experience, the clinically significant leak rate for both open and thoracoscopic repair as well as recurrent fistula is much lower than has been reported in the literature. We do not routinely perform contrast studies and are, thus, reporting clinically significant leaks only. The use of post-operative neck flexion, ventilation and paralysis is likely to be protective towards a leak. Thoracoscopic OA/TOF repair is associated with a higher stricture rate compared with open surgery; however, these strictures respond to a similar number of dilatations and are no more refractory. Larger, multicentre studies may be useful to investigate these finding further.
Prognostic value of NT-proBNP for myocardial recovery in peripartum cardiomyopathy (PPCM)
Authors: Hoevelmann J. , Muller E. , Azibani F. , Kraus S. , Cirota J. , Briton O. , Ntsekhe M. , Ntusi N. A. B. , Sliwa K. , Viljoen C. A.
Published: February 2021

Introduction

Peripartum cardiomyopathy (PPCM) is an important cause of pregnancy-associated heart failure worldwide. Although a significant number of women recover their left ventricular (LV) function within 12 months, some remain with persistently reduced systolic function.

Methods

Knowledge gaps exist on predictors of myocardial recovery in PPCM. N-terminal pro-brain natriuretic peptide (NT-proBNP) is the only clinically established biomarker with diagnostic value in PPCM. We aimed to establish whether NT-proBNP could serve as a predictor of LV recovery in PPCM, as measured by LV end-diastolic volume (LVEDD) and LV ejection fraction (LVEF).

Results

This study of 35 women with PPCM (mean age 30.0 ± 5.9 years) had a median NT-proBNP of 834.7 pg/ml (IQR 571.2–1840.5) at baseline. Within the first year of follow-up, 51.4% of the cohort recovered their LV dimensions (LVEDD < 55 mm) and systolic function (LVEF > 50%). Women without LV recovery presented with higher NT-proBNP at baseline. Multivariable regression analyses demonstrated that NT-proBNP of ≥ 900 pg/ml at the time of diagnosis was predictive of failure to recover LVEDD (OR 0.22, 95% CI 0.05–0.95, P = 0.043) or LVEF (OR 0.20 [95% CI 0.04–0.89], p = 0.035) at follow-up.

Conclusions

We have demonstrated that NT-proBNP has a prognostic value in predicting LV recovery of patients with PPCM. Patients with NT-proBNP of ≥ 900 pg/ml were less likely to show any improvement in LVEF or LVEDD. Our findings have implications for clinical practice as patients with higher NT-proBNP might require more aggressive therapy and more intensive follow-up. Point-of-care NT-proBNP for diagnosis and risk stratification warrants further investigation.
App-based rehabilitation program after total knee arthroplasty: a randomized controlled trial
Authors: Bäcker Henrik C. , Wu Chia H. , Schulz Matthias R. G. , Weber-Spickschen Thomas Sanjay , Perka Carsten , Hardt Sebastian
Published: February 2021

Introduction

New app-based programs for postoperative rehabilitation have been developed, but no long-term study has been published to date. Thus, a prospective randomized control trial with 2-year follow-up was performed to evaluate the effectiveness of app-based rehabilitation (GenuSport) compared to a control group after total knee arthroplasty (TKA).

Methods

Between April and October 2016, 60 patients were enrolled in the study. Twenty-five patients were lost to follow-up, leaving 35 patients undergoing TKA for inclusion. In this group, twenty patients received app-based exercise program and 15 were randomized to the control group. The mean age was 64.37 ± 9.32 years with a mean follow-up of 23.51 ± 1.63 months. Patients in the app group underwent an app-based knee training starting on the day of surgery; whereas, patients in the control group underwent regular physiotherapy. Functional outcome scores using the Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Society Score (KSS) and VAS of pain were analyzed.

Results

In the short term, significant differences between the app group and control group in time of 10-m walk (19.66 ± 7.80 vs. 27.08 ± 15.46 s; p = 0.029), VAS pain at rest and activity (2.65 ± 0.82 vs. 3.57 ± 1.58, respectively 4.03 ± 1.26 vs. 5.05 ± 1.21; p < 0.05) were observed. In the long term, a variety of different tendencies was found, highest in KSS Function with 76.32 ± 16.49 (app group) vs. 67.67 ± 16.57 (control group) (p = 0.130). Additionally, patients in the app group required less painkillers (10.0% vs. 26.7%) and more likely to participate in sports (65.0% vs. 53.3%).

Conclusions

An app-based knee trainer is a promising tool in improving functional outcomes such as KSS function score and VAS after TKA.

Level of evidence

Level II, prospective randomized control trial.
Does hysteroscopic resection of uterine septum improve reproductive outcomes: a systematic review and meta-analysis
Authors: Krishnan Monica , Narice Brenda F. , Ola Bolarinde , Metwally Mostafa
Published: February 2021

Purpose

Uterine septum in women with subfertility or previous poor reproductive outcomes presents a clinical dilemma. Hysteroscopic septum resection has been previously associated with adverse reproductive outcomes but the evidence remains inconclusive. We aimed to thoroughly and systematically appraise relevant evidence on the impact of hysteroscopically resecting the uterine septum on this cohort of women.

Methods

AMED, BNI, CINAHL, EMBASE, EMCARE, Medline, PsychInfo, PubMed, Cochrane register of controlled trials, Cochrane database of systematic reviews and CINAHL were assessed to April 2020, with no language restriction. Only randomised control trials and comparative studies which evaluated outcomes in women with uterine septum and a history of subfertility and/or poor reproductive outcomes treated by hysteroscopic septum resection against control were included. The primary endpoint was live birth rate, whereas clinical pregnancy, miscarriage, preterm birth and malpresentation rates were secondary outcomes.

Results

Seven studies involving 407 women with hysteroscopic septum resection and 252 with conservative management were included in the meta-analysis. Hysteroscopic septum resection was associated with a lower rate of miscarriage (OR 0.25, 95% CI 0.07–0.88) compared with untreated women. No significant effect was seen on live birth, clinical pregnancy rate or preterm delivery. However, there were fewer malpresentations during labour in the treated group (OR 0.22, 95% CI 0.06–0.73).

Conclusion

Our review found no significant effect of hysteroscopic resection on live birth. However, given the limited evidence available, high-quality randomised controlled trials are recommended before any conclusive clinical guidance can be drawn.
Developmental differences across the lifespan in the use of perceptual information to guide action-based decisions
Authors: Stafford James , Rodger Matthew , Gómez-Jordana Luis I. , Whyatt Caroline , Craig Cathy M.
Published: February 2021

Perceptual information about unfolding events is important for guiding decisions about when and how to move in real-world action situations. As an exemplary case, road-crossing is a perceptual-motor task where age has been shown to be a strong predictor of risk due to errors in action-based decisions. The present study investigated age differences between three age groups (Children: 10–12 years old; Adults: 19–39 years old; Older Adults: 65 + year olds) in the use of perceptual information for selection, timing, and control of action when crossing a two-way street in an immersive, interactive virtual reality environment. Adults and children selected gaps to cross that were consistent with the use of a time-based information variable (tau), whereas older adults tuned less into the time-based variable (tau) to guide road-crossing decisions. For action initiation and control, children and adults also showed a strong ability to precisely time their entry with respect to the lead vehicle maximising the available time to cross and coordinating walking movements with the tail vehicle to ensure they were not on a collision course. In contrast, older adults delayed action initiation and showed difficulty coordinating self-movement with the approaching vehicle. This study and its results tie together age-based differences in the three components of action decision-making (selection, timing and control) within a unified framework based on perceptual information. The implications of these age-related differences in action decisions and crossing behaviours are discussed in the context of road safety.
Recent advances and conceptual changes in the classification of neuroendocrine tumors of the thymus
Authors: Bohnenberger Hanibal , Ströbel Philipp
Published: February 2021

Neuroendocrine tumors of the thymus (TNET) are exceedingly rare neoplasms. Their histomorphology is identical to neuroendocrine tumors elsewhere in the body (in particular the lungs) and bears no similarity with thymomas and thymic carcinomas. Recent molecular findings have profoundly changed our perception of these tumors and may impact future histological classification systems.
Ecophysiological, morphological, and biochemical traits of free-living Diplosphaera chodatii (Trebouxiophyceae) reveal adaptation to harsh environmental conditions
Authors: Medwed Cynthia , Holzinger Andreas , Hofer Stefanie , Hartmann Anja , Michalik Dirk , Glaser Karin , Karsten Ulf
Published: February 2021

Single-celled green algae within the Trebouxiophyceae (Chlorophyta) are typical components of terrestrial habitats, which often exhibit harsh environmental conditions for these microorganisms. This study provides a detailed overview of the ecophysiological, biochemical, and ultrastructural traits of an alga living on tree bark. The alga was isolated from a cypress tree in the Botanical Garden of Innsbruck (Austria) and identified by morphology and molecular phylogeny as Diplosphaera chodatii. Transmission electron microscopy after high-pressure freezing (HPF) showed an excellent preservation of the ultrastructure. The cell wall was bilayered with a smooth inner layer and an outer layer of polysaccharides with a fuzzy hair-like appearance that could possibly act as cell-cell adhesion mechanism and hence as a structural precursor supporting biofilm formation together with the mucilage observed occasionally. The photosynthetic-irradiance curves of D. chodatii indicated low light requirements without photoinhibition at high photon flux densities (1580 μmol photons m−2 s−1) supported by growth rate measurements. D. chodatii showed a high desiccation tolerance, as 85% of its initial value was recovered after controlled desiccation at a relative humidity of ~10%. The alga contained the low molecular weight carbohydrates sucrose and sorbitol, which probably act as protective compounds against desiccation. In addition, a new but chemically not elucidated mycosporine-like amino acid was detected with a molecular mass of 332 g mol−1 and an absorption maximum of 324 nm. The presented data provide various traits which contribute to a better understanding of the adaptive mechanisms of D. chodatii to terrestrial habitats.
Model-based optimization of ARINC-653 partition scheduling
Authors: Han Pujie , Zhai Zhengjun , Nielsen Brian , Nyman Ulrik
Published: February 2021

The architecture of ARINC-653 partitioned scheduling has been widely applied to avionics systems owing to its robust temporal isolation among applications. However, this partitioning mechanism causes the problem of how to optimize the partition scheduling of a complex system while guaranteeing its schedulability. In this paper, a model-based optimization approach is proposed. We formulate the problem as a parameter sweep application, which searches for the optimal partition scheduling parameters with respect to minimum processor occupancy via an evolutionary algorithm. An ARINC-653 partitioned scheduling system is modeled as a set of timed automata in the model checker UPPAAL. The optimizer tentatively assigns parameter settings to the models and subsequently invokes UPPAAL to verify schedulability as well as evaluate promising solutions. The parameter space is explored with an evolutionary algorithm that combines refined genetic operators and the self-adaptation of evolution strategies. The experimental results show the applicability of our optimization method.
Long-term sero-positivity for IgG, sequelae of respiratory symptoms, and abundance of malformed sperms in a patient recovered from severe COVID-19
Authors: Zhu Mingchao , Chen Diliang , Zhu Ya , Xiong Xusheng , Ding Yan , Guo Feibo , Zhu Mingan , Zhou Junyang
Published: February 2021

Patients with severe coronavirus disease in 2019 (COVID-19 pneumonia) may have many sequelae, which seriously affect their quality of life and work. Here, we report a case of infection in China, reviewed the course, treatment, and rehabilitation of a patient suffering from severe COVID-19 pneumonia, and collected his examination reports, including chest CT, laboratory examination results, lung function examination, sleep monitoring report, sex hormones, sperm morphology and activity. The patient’s antiviral immunoglobulin G (IgG) continued to be positive for more than 11 months, and his small airway function was abnormal, and he suffered from respiratory problems (cough, chest pain, chest tightness, and shortness of breath), unstructured sleep apnea hypopnea syndrome, and nocturnal sleep hypoxemia. His abnormal sperm rate increased obviously, and sperm activity decreased obviously. Patients with severe COVID-19 pneumonia may have respiratory sequela, the abnormal sperm rate is obviously increased, and IgG positive can last for a long time.
Survival of wild and farmed-released mallards: the Swedish example
Authors: Söderquist Pär , Gunnarsson Gunnar , Elmberg Johan , Dessborn Lisa
Published: February 2021

More than three million farmed mallards are released annually for hunting purposes in Europe. The ecological impact of these releases depends on how many birds survive to join the wild breeding population. We estimated annual survival in farmed-released and wild-caught Swedish mallards, using mark-recapture data. In 2011–2018, we ringed 13,533 farmed ducklings before release (26.5% recovered). Most recoveries were birds shot at the release site, while only about 4% were found >3 km away. In 2002–2018, 19,820 wild mallards were ringed in Sweden, yielding 1369 (6.9%) recoveries. Like in farmed-released birds, most recoveries were by hunting, but 91.1% of recovered wild mallards were >3 km away from the ringing site. Annual survival rate in farmed-released mallards (ringed as pulli) was 0.02. In wild mallards (ringed as fledged or fully grown), annual survival was lower in females (0.64) than in males (0.71). At two sites in 2018, farmed ducklings were released in two batches 3 weeks apart to study the effect of early versus late release date, while controlling for body condition (BCI). Ducklings released early had a higher BCI and were recovered earlier (lower longevity) than those released late. Individual BCI and longevity were not correlated in recovered ducklings. Based on our estimate of annual survival in farmed-released mallards, a substantial number, i.e., 5000 (95% CI, 3040–6960), join the wild population annually. Despite being fed, a large proportion of released ducklings does not survive until the hunting season. Early releases may maximize pre-hunting survival. Repeated releases may prolong hunting opportunities and increase hunting bags.
Cardiac magnetic resonance in patients with ARVC and family members: the potential role of native T1 mapping
Authors: Georgiopoulos Georgios , Zampieri Mattia , Molaro Silvia , Chaloupka Anna , Aimo Alberto , Barra Barbara , Roberts Leema , Monje-Garcia Laura , Evans Colin , Sheikh Nabeel , Bastiaenen Rachel , Cooklin Michael , Masci Pier-Giorgio , Carr-White Gerald , Finocchiaro Gherardo , Chiribiri Amedeo
Published: February 2021

Left ventricular (LV) involvement in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) is not evaluated in the revised Task Force Criteria, possibly leading to underdiagnosis. This study explored the diagnostic role of myocardial native T1 mapping in patients with ARVC and their first-degree relatives. Thirty ARVC patients (47% males, mean age 45 ± 27 years) and 59 first-degree relatives not meeting diagnostic criteria underwent CMR with native T1 mapping. C MR was abnormal in 26 (87%) patients with ARVC. The right ventricle was affected in isolation in 13 (43%) patients. Prior to T1 mapping assessment, 2 (7%) patients exhibited isolated LV involvement and 11 (36%) patients showed features of biventricular disease. Left ventricular involvement was manifest as detectable LV late gadolinium enhancement (LGE) in 12 out of 13 cases. According to pre-specified inter-ventricular septal (IVS) T1 mapping thresholds, 11 (37%) patients revealed raised native T1 values including 5 out of the 17 patients who would otherwise have been classified as exhibiting a normal LV by conventional imaging parameters. Native septal T1 values were elevated in 22 (37%) of the 59 first-degree relatives included. Biventricular involvement is commonly observed in ARVC; native myocardial T1 values are raised in more than one third of patients, including a significant proportion of cases that would have been otherwise classified as exhibiting a normal LV using conventional CMR techniques. The significance of abnormal T1 values in first-degree relatives at risk will need validation through longitudinal studies.
A fair trade? Expert perceptions of equity, innovation, and public awareness in China’s future Emissions Trading Scheme
Authors: Ying Jiangyue Joy , Sovacool Benjamin K.
Published: February 2021

How can the Chinese emissions trading scheme (ETS) be redesigned or improved to better address issues of fairness and equity, innovation and learning, and awareness and social acceptance? In order to meet its 2030 carbon emission reduction pledges, the Chinese government has announced plans for a fully implementable national carbon ETS after 2020. This scheme is set to become the world’s most significant carbon trading market and it could cover half of all Chinese CO2emissions (as much as 4 billion tons of carbon dioxide). In this study, we qualitatively analyze the Chinese ETS through the lens of three interconnected themes—equity, innovation, and awareness—which are disaggregated into six specific dimensions. We then explore these themes and dimensions with a mixed methods and original research design involving a survey of 68 Chinese experts as well as 34 semi-structured research interviews with respondents from local governments, financial institutions, technology service companies, universities, industries, and civil society groups. We find that uneven economic and social growth could exacerbate any initial permits allocation scheme that could be a cornerstone for an ETS. Substantial technological and institutional uncertainties exist that could also hamper development and enforcement. Low or negative awareness among the public and private sector were identified as also being significant barriers for ETS implementation.
An assessment of the interplay between literacy and digital Technology in Higher Education
Authors: Nikou Shahrokh , Aavakare Milla
Published: February 2021

Digital technologies fundamentally transform teaching and learning in higher education environments, with the pace of technological change exacerbating the challenge. Due to the current pandemic situation, higher education environments are all now forced to move away from traditional teaching and learning structures that are simply no longer adaptable to the challenges of rapidly changing educational environments. This research develops a conceptual model and employs Structural Equation Modelling (SEM) using Partial least Squares (PLS) to examine the impact of information and digital literacy on 249 Finnish university staff and students’ intention to use digital technologies. The findings show the complex interrelationship between literacy skills and digital technologies among university staff and students. The results illustrate that information literacy has a direct and significant impact on intention to use; while, unlike our expectation, digital literacy does not have a direct impact on the intention to use. However, its effect is mediated through performance expectancy and effort expectancy. The authors suggest that to understand the changes that are taking place in higher education environment, more attention needs to be paid to redefining policies and strategies in order to enhance individuals’ willingness to use digital technologies within higher education environments.
Parental Perspectives on Storybook Reading in Indian Home Contexts
Authors: Pandith Pooja , John Sunila , Bellon-Harn Monica L. , Manchaiah Vinaya
Published: February 2021

The benefits of parent–child storybook reading experiences in the home are well documented. However, there is a dearth of information regarding parent–child storybook reading experiences in Indian home contexts. This study investigated parental perspectives towards storybook reading in the Indian context among 100 parents of typically developing preschool children. In this questionnaire-based study, parental responses were collected and the patterns of reading exposure, child’s interest in reading, storybook reading practices, and attitudes & beliefs towards storybook reading were reported using descriptive statistics. Correlation between demographic variables (i.e., child’s age and socioeconomic status) and storybook reading domains were explored. The majority of parents initiated storybook reading with their children at 2 years of age or older. Parents read to their children one to two times per week for 10 min and had fewer than 10 books in the home. Parents reported that their children were interested in storybook reading and reported the use of quality storybook reading practices. Homes characterized with higher socioeconomic status included more quality home literacy environment factors, although socioeconomic status did not correlate with the parental beliefs and attitudes towards reading. Results provide preliminary information regarding parental perspectives on storybook reading in Indian home contexts and point toward socioeconomic and sociocultural variation in home literacy environments. Understanding more about the parental interactions surrounding storybook reading will facilitate the development of parent programs to enhance and promote quality home literacy environment in Indian home contexts.
Subjectivity and Transcendental Illusions in the Anthropocene
Authors: De Preester Helena
Published: February 2021

This contribution focuses on one member in particular of the anthropocenic triad Earth – technology – humankind, namely the current form of human subjectivity that characterizes humankind in the Anthropocene. Because knowledge, desire and behavior are always embedded in a particular form of subjectivity, it makes sense to look at the current subjective structure that embeds knowledge, desire and behavior. We want to move beyond the common psychological explanations that subjects are unable to correctly assess the consequences of their current technological lifestyle or unable to change their lifestyle because well-intended behavior is modified by factors such as laziness, lack of knowledge, seduction by convenience, etc. Instead, we will argue from a philosophical point of view that transcendental illusions play a central role in a contemporary account of subjectivity. Consumerism is considered as a means of not becoming a subject and framed in a profound ambivalence at the heart of our acting (consuming) against better knowledge. We appeal to collective transcendental conditions of subjectivity in the Anthropocene in terms of illusions without owners – a term borrowed from Robert Pfaller’s work on interpassivity. Central in our account is the idea that illusions without owners are the conditions of possibility for the disconnection between knowledge and behavior – the characteristic par excellence of the Anthropocene.
Combined Visco-Trab operation: A dual filtration pathway for management of advanced glaucoma—midterm results
Authors: Eid Tarek M. , Ibrahim Ezz El-Din M. , Zaid Ahmad
Published: February 2021

Purpose

To study midterm efficacy and safety of combined Visco-Trab operation for management of advanced glaucoma.

Methods

168 eyes of 148 patients with advanced glaucoma had Visco-Trab operation (a merge of both viscocanalostomy and trabeculectomy operations). Mean follow-up was 29.1 ± 22.2 months. Criteria of success were intraocular pressure (IOP) of 14 mmHg or less with or without glaucoma medications, with no devastating complications, loss of light perception, or additional glaucoma surgery.

Results

IOP, number of glaucoma drops, and visual field mean deviation were significantly reduced (11.9 ± 5.6 mmHg, 0.7 ± 1.2, and 14.2 ± 6.3 dB, compared to preoperative values of 24.4 ± 9.9 mmHg, 2.8 ± 1.4, and 17.3 ± 6.3 dB, respectively). Success was reported in 136 of 168 eyes (81%) without (100 eyes, 59.5%) or with (36 eyes, 21.5%) glaucoma medications. A functioning bleb was seen in 2/3rd of eyes; diffuse (59 eyes, 35%) and thin ischemic (54 eyes, 32%). Predictors for failure to achieve the target IOP included previous ocular (p = 0.01) or glaucoma (p = 0.04) surgery, number of preoperative glaucoma medications (p = 0.029), and severity of glaucoma (p = 0.058).

Conclusion

Combined Visco-Trab operation proved safe and effective, on midterm follow-up, in reducing IOP to the proposed target level in eyes with severe glaucoma via enhancing internal and external filtration.
Thematic Reclassifications and Emerging Sciences
Authors: Sandoz Raphaël
Published: February 2021

Over time, various thematic classifications have been put forward to organize science into a coherent system of specialized areas of research. From an analysis of the historical evolution of the criteria used to distinguish the sciences from one another, I propose in this paper a quadripartite typology for the different thematic classification systems propounded by scholars throughout the centuries. Basically, I argue that the criteria used to differentiate the sciences have been alternately drawn from their respective subject matters, kinds of knowledge, methods and aims. Then, I show that several reclassifications occurred in the thematic structure of science. Finally, I argue that such changes in the structure of learning displaced the modalities of contact between the objects, knowledge, methods and aims of the various branches of science, with the result of outlining reshaped intellectual territories conducive to the emergence of new areas of research.
Combined thermal analysis of plant oils
Authors: Tamási Kinga , Marossy Kálmán
Published: February 2021

The paper deals with the study of seven selected natural plant oils. Differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA) and thermally stimulated discharge (TSD) methods were used. It has been found that most of the oils tested are in a glassy state at low temperature and have multiple transitions in the low temperature range. DSC shows complex melting-like processes or glass transition. For both DMA and TSD, the scaffold supportive method was used and found as a suitable one. DMA and TSD proved more sensitive than DSC and revealed at least two transitions between − 120 and − 40 °C. In the case of three oils (argan, avocado and sunflower), current reversal was observed by TSD; this symptom cannot be fully explained at the moment.
Top program construction and reduction for polynomial time Meta-Interpretive learning
Authors: Patsantzis S. , Muggleton S. H.
Published: February 2021

Meta-Interpretive Learners, like most ILP systems, learn by searching for a correct hypothesis in the hypothesis space, the powerset of all constructible clauses. We show how this exponentially-growing search can be replaced by the construction of a Top program: the set of clauses in all correct hypotheses that is itself a correct hypothesis. We give an algorithm for Top program construction and show that it constructs a correct Top program in polynomial time and from a finite number of examples. We implement our algorithm in Prolog as the basis of a new MIL system, Louise, that constructs a Top program and then reduces it by removing redundant clauses. We compare Louise to the state-of-the-art search-based MIL system Metagol in experiments on grid world navigation, graph connectedness and grammar learning datasets and find that Louise improves on Metagol’s predictive accuracy when the hypothesis space and the target theory are both large, or when the hypothesis space does not include a correct hypothesis because of “classification noise” in the form of mislabelled examples. When the hypothesis space or the target theory are small, Louise and Metagol perform equally well.
Rho-kinase inhibitor hydroxyfasudil protects against HIV-1 Tat-induced dysfunction of tight junction and neprilysin/Aβ transfer receptor expression in mouse brain microvessels
Authors: Chen Qiangtang , Wu Yu , Yu Yachun , Wei Junxiang , Huang Wen
Published: February 2021

HIV-1 transactivator protein (Tat) induces tight junction (TJ) dysfunction and amyloid-beta (Aβ) clearance dysfunction, contributing to the development and progression of HIV-1-associated neurocognitive disorder (HAND). The Rho/ROCK signaling pathway has protective effects on neurodegenerative disease. However, the underlying mechanisms of whether Rho/ROCK protects against HIV-1 Tat-caused dysfunction of TJ and neprilysin (NEP)/Aβ transfer receptor expression have not been elucidated. C57BL/6 mice were administered sterile saline (i.p., 100 μL) or Rho-kinase inhibitor hydroxyfasudil (HF) (i.p., 10 mg/kg) or HIV-1 Tat (i.v., 100 μg/kg) or HF 30 min before being exposed to HIV-1 Tat once a day for seven consecutive days. Evans Blue (EB) leakage was detected via spectrophotometer and brain slides in mouse brains. The protein and mRNA levels of zonula occludens-1 (ZO-1), occludin, NEP, receptor for advanced glycation end products (RAGE), and low-density lipoprotein receptor-related protein 1 (LRP1) in mouse brain microvessels were, respectively, analyzed by Western blotting and quantitative real-time polymerase chain reaction (qRT-PCR) analyses. Exposure of the mice to HIV-1 Tat increased the amount of EB leakage, EB fluorescence intensity, blood–brain barrier (BBB) permeability, as well as the RAGE protein and mRNA levels, and decreased the protein and mRNA levels of ZO-1, occludin, NEP, and LRP1 in mouse brain microvessels. However, these effects were weakened by Rho-kinase inhibitor HF. Taken together, these results provide information that the Rho/ROCK signaling pathway is involved in HIV-1 Tat-induced dysfunction of TJ and NEP/Aβ transfer receptor expression in the C57BL/6 mouse brain. These findings shed some light on potentiality of inhibiting Rho/Rock signaling pathway in handling HAND.
Assessing the value of household work based on wages demanded on online platforms for substitutes
Authors: Jokubauskaitė Simona , Schneebaum Alyssa
Published: February 2021

We propose an improved method to assess the economic value of unpaid housework and childcare. Existing literature has typically assigned a minimum, generalist or specialist’s wage, or the performer’s opportunity cost to the hourly value of these activities. Then it was used to calculate macro-level value based on the number of hours spent in this work. In this paper, instead of imputing an average or minimum wage for housework and childcare to determine a value to the work, we use the actual local wage rate requested for these services from providers on online platforms. Applying this method to Austrian Time Use Survey data shows that the value of unpaid childcare and housework, had it been paid, would be equivalent to about 22% of the 2018 GDP.
A Systematic Reconstruction of Brentano’s Theory of Consciousness
Authors: Marchesi Andrea
Published: February 2021

In recent years, Brentano’s theory of consciousness has been systematically reassessed. The reconstruction that has received the most attention is the so-called identity reconstruction. It says that secondary consciousness and the mental phenomenon it is about are one and the same. Crucially, it has been claimed that this thesis is the only one which can make Brentano’s theory immune to what he considers the main threat to it, namely, the duplication of the primary object. In this paper, I argue that the identity reconstruction is untenable, and I defend an alternative, which I name the unity reconstruction. According to the unity reconstruction, secondary consciousness is a real part of the mental phenomenon it is about, and hence is distinct from it. I contend that this thesis does not in itself lead to the duplication of the primary object, and that what should be blamed is rather a controversial thesis about the intentional structure of secondary consciousness—a thesis which Brentano ultimately abandoned.
Living in the concrete jungle: a review and socio-ecological perspective of urban raptor habitat quality in Europe
Authors: Mak Brandon , Francis Robert A. , Chadwick Michael A.
Published: February 2021

Raptors can be important components of urban ecosystems due to their role as apex predators, the presence of which may bring benefits to people. Urban environments may provide good quality habitats, and the raptors’ ability to utilize resources found here can contribute to their success. However, urban environments are socio-ecological systems and such mechanisms shaping habitats and ecological resources therein are less understood. This paper explores how raptors utilize urban resources, and the socio-ecological processes influencing their quality and availability. It begins with a systematic mapping of the literature to summarize the utility of urban resources by raptors with European distributions. Eighteen species were documented in the literature successfully exploiting novel hunting and/or nesting opportunities in both green and built-up locations of urban areas. We discuss how these may be consequential of human activities, some of which intentionally provided as subsidies, and how their utility by raptors create opportunities for human-raptor interactions further shaping public perception and decisions which potentially affect the raptors. Finally, we demonstrate these concepts by drawing on our experience from an urban peregrine falcon (Falco peregrinus) conservation site in London, UK. The paper concludes with a call for urban raptor conservation and research to consider social and ecological aspects together, appropriately reflecting urban environments as socio-ecological systems.
RETRACTED ARTICLE: The shadow economy in South Asia: dynamic effects on clean energy consumption and environmental pollution
Authors: Sohail Muhammad Tayyab , Ullah Sana , Majeed Muhammad Tariq , Usman Ahmed , Andlib Zubaria
Published: February 2021

This study explores the symmetric and asymmetric effects of the shadow economy on clean energy and air pollution of South Asian countries over the period 1991–2019. The short-run ARDL findings for the clean energy model suggest that shadow economy increases clean energy consumption in Pakistan and Sri Lanka, whereas this effect is negative for India and insignificant for other countries. The long-run results indicate the adverse impact only for India and the effects of tax revenue on clean energy are positively significant in Sri Lanka while negatively signiicant in Nepal and Bangladesh. Institutional quality significantly increases clean energy in Pakistan, India, and Nepal. However, in the case of Pakistan and Nepal, institutional quality deteriorated the environmental quality. The results for the pollution model confer that shadow economy increases emissions in Pakistan, decreases in Bangladesh and Nepal, and has no effect in India and Sri Lanka. The nonlinear ARDL results reveal that the positive components of the shadow economy significantly increase clean energy consumption only in Pakistan; however, the negative components of the shadow economy are negatively significant in all countries except Sri Lanka and Nepal. However, the negative component of the informal sector of the economy reduces CO2 emissions in India and increases CO2 emissions in Bangladesh and Nepal. The results offer important policy implications for achieving clean energy and better environmental quality in South Asian countries.
Five decades of corporate entrepreneurship research: measuring and mapping the field
Authors: Glinyanova Maria , Bouncken Ricarda B. , Tiberius Victor , Cuenca Ballester Antonio C.
Published: February 2021

Research on corporate entrepreneurship—venturing activities by established corporations—has received increasing scholarly attention. We employ bibliometric methods to analyze the literature on corporate entrepreneurship published over the last five decades. Based on the results of citation and co-citation analyses, we reveal central works in the field and how they are interconnected. We investigate the underlying intellectual structure of the field. Our findings provide evidence of the growing maturity and interdisciplinarity of corporate entrepreneurship and provide insight into research themes. We find that resource-based view and its extensions still remain the predominant theoretical perspectives in the field. Drawing on these findings, we suggest directions for future research.