bluuebunny/crossref_metadata_2025 huggingface dataset:
KOMUNIKASI NEGOSIASI INDIVIDU GAY DALAM MEMUTUSKAN VCT SECARA SUKARELA
Authors: Pudrianisa Sheila Lestari Giza
Published: July 2019

AbstrakPenelitian ini bertujuan untuk memahami proses komunikasi negosiasi individu gaymemutuskan VCT (Voluntary, Counseling and Tasting) serta pendampingan secara sukarela.Informan penelitian adalah LSL yang tergabung dalam Semarang GAY@ Community yang terdiriatas tiga orang LSL negatif dan tiga orang LSL positif. Keluarga, teman dan pacar sesama LSLberpengaruh pada pengambilan keputusan saat proses negosiasi berjalan. Proses komunikasinegosiasi menggunakan tiga pendekatan yaitu framing sebagai posisi tawar, penyusunan pesan sebagai elemen dalam membentuk pesan persuasi, dan mengelola hubungan antara LSL dengan Dinas Kesehatan yang menyediakan layanan tes gratis dan layanan konseling(VCT) rutin, yang ditandai dengan perjanjian tertulis atau penandatangan kontrak sebagaibentuk kesepakatan antara negosiator (petugas kesehatan) dengan narasumber. Penelitianini menghasilkan sikap sukarela karena terdorong rasa tanggung jawab terhadap diri sendiridengan konsep komunikasi negosiasi berulang (multilayer negotiation) menggunakan gayakomunikasi yang berbeda yaitu karena paksaan, imbalan serta rasa penasaran.Kata kunci: Negosiasi berulang, LSL, VCT, ODHAAbstractThis research has purpose to understand a process communication of negotiation guyindividuals decide on VCT (Voluntary, Counseling and Tasting) as well as voluntary colleague.The research information were MSM who joined in Semarang GAY@ community consists thatof three persons negative and three persons positive include family,friends, girl or boy friendof MSM has an effect decision when during negotiation process. The process negotation usesthree approachs such as framing become undisturbed position,composing massage becomeelement and then massage transform persuasi, and can make relationship between MSM andpublic health office that provide service free test and conseling services (VCT), as indicated bya agreement or sign contract as a form of agreement between the negotiator (health worker)and the resource persen. This research can produce a voluntary attitude inasmuch as it shoveda sense of responsibility towards oneself with concept repeatation negotiation communication(multilayer negotiation) can use different communication such as compulsion,wage,andcurious.Keywoards: Multilayer negotiation, MSM, VCT, ODHA.
REPRESENTASI IDENTITAS “COMFORT WOMEN” DALAM FILM I CAN SPEAK THE REPRESENTATION OF “COMFORT WOMEN” IDENTITY IN THE KOREAN MOVIE TITLED I CAN SPEAK
Authors: Fauziatunnisa Fauziatunnisa , Hapsari Swita Amallia
Published: July 2019

AbstrakFilm Korea yang berjudul I Can Speak merupakan film yang diadaptasi dari kisah nyatatentang comfort women di Korea Selatan dan Jepang. Film ini menggunakan genre komedidan menjelaskan tentang seorang perempuan yang berjuang mencari keadilan atas kasuswanita penghibur atau comfort women selama lebih dari satu tahun. Penelitian ini fokus padarepresentasi identitas comfort women dalam film “I Can Speak”. Penelitian ini menggunakanpendekatan kualitatif dan dikaji melalui teknik analisa Semiotika dari Roland Barthes. Untukmendapatkan tujuan dari penelitian, maka digunakan teori Gender Struktural Fungsionaldan teori pendukung The Second Sex dalam kajian feminis untuk melengkapi analisa. Hasildari penelitian ini yakni menjelaskan bahwa perempuan dijadikan objek seksual oleh militerJepang yang dikenal sebagai comfort women. Film ini menyampaikan pesan bahwa perempuandipandang sebagai orang kedua atau tidak menjadi prioritas dari laki-laki yang dikenal dengan(liyan). Gagasan dari korban comfort women ini adalah sejarah yang terlupakan dalam filmI Can Speak menggambarkan dengan jelas bahwa para korban masih memperjuangkan hakmereka. Comfort women menjadi isu sensitif dan masih menjadi topik serius hingga saat ini.Kata kunci : Analisis semiotika, comfort women, gender structural fungsional, Representasi, film AsbstractThe Korean movies titled  I Can Speak is an adapted movie based on true story of comfort womenat South Korea and Japan. This movie featuring a comedy genre and describe a woman whofight for her justice a comfort women victim over the years. This study focus on representativeof comfort women identity in the movie titled “I can speak”. This type of research is a qualitativemethod using semiotic data with  Roland Barthes analysis technique. To achieve the purposeof the study, a functional structural gender theory and a feminism philosophy of the secondsex support and complete the analysis . The result of this study, describe that women had been used as a sexual object for Japanese military satisfaction which is later known as comfort women. This film deliver a message of women’s become the second sex or not priority thanmen’s identified as (liyan). The idea of comfort women victim is a forgotten history yet in themovie “I Can Speak” clearly illustrate that the victims still struggling to fight for their right.Comfort women is become the sensitive issue and being a serious topic until these day.Keywords: Comfort women, functional structural gender, representative film, semiotic analysis
Losing sight of women's rights: the unregulated introduction of gender self-identification as a case study of policy capture in Scotland
Authors: Murray Kath , Hunter Blackburn Lucy
Published: July 2019

Within the last two years, respective proposals by the Scottish and UK Governments to reform the Gender Recognition Act 2004 (GRA) to allow people to change their legal sex based only on making a legally-registered self-declaration have sparked an intense debate on how sex and gender identity should be defined in law and policy. This paper examines how gender self-identification had in fact become a feature of Scottish policy-making and practice, long before public consultation on GRA reform began. The analysis is structured as two case-studies that examine firstly, policy development on the census in relation to the ‘sex’ question, and second, Scottish Prison Service policy on transgender prisoners. The analysis shows that the unregulated roll-out of gender self-identification in Scotland has taken place with weak or non-existent scrutiny and a lack of due process, and that this relates to a process of policy capture, whereby decision-making on sex and gender identity issues has been directed towards the interests of a specific interest group, without due regard for other affected groups or the wider population. The paper raises questions about the adequacy of institutional safeguards against well-organised and highly purposeful lobbying, particularly where any groups detrimentally affected do not have effective representation.
The relationship between Medical Outcomes Study Short Form-36 (SF-36) and conventional objective outcome scales in patients with postoperative tibial plateau fractures
Authors: TAŞDEMİR Zeki , GÜZEL Şevket Ergün
Published: July 2019

Objective: Patient-based outcome measures are actively utilized within
the subjective health status and functional status of life. The aim of this
study was to evaluate the correlation between existing Knee Society Score(KSS),
Knee injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and
McMaster University Osteoarthritis Index (WOMAC) and the Medical Outcomes Study
Short Form-36 (SF-36) and to evaluate their correlation with each other as well
as to evaluate their measurement capabilities.Materials and Methods: In the study, we have retrospectively evaluated
43 healthy knees and 43 operated knees of a total of 43 patients with Schatzker
type 2 and type 3 tibial plateau fractures that were treated surgically between
July 2010 and March 2016 in our clinic. Patients were evaluated weekly with
SF-36 General Physical Functional Score and also with the WOMAC, KSS and KOOS
scoring systems, which are scoring systems that are used to address
specifically the problems with the knee joint.

Result and Conclusion: The KSS Functional Score and the KOOS Daily
Functional Score were found to be reliable for the functional evaluation of the
knee joint. We believe that the numerical scoring system used by WOMAC
Functional Scoring causes distraction and we believe that the measurement
effectiveness is reduced as a result. As a result of this study, we think that
we need to be very careful when selecting and using evaluation scales where the
responses are first matched to numerical values.
THE IMPACT OF OIL PRICE ON ECONOMIC GROWTH: AN INVESTIGATION ON IRAQI ECONOMY
Authors: AKTUĞ Semih Serkant , DAĞ Mehmet , STAR Hawar Rafaat
Published: July 2019

Iraq is one of the leading oil exporting countries. In general, the national income of the country depends on crude oil. Oil revenues in Iraq cover 90 percent of the Iraqi government's budget. The rising crude oil price may affect the economic growth in Iraq. On the other hand, it is very important to use another resource instead of oil revenues as a new strategy for national income. The main purpose of this study is to examine the effects of oil price and oil production value on economic growth in Iraq. For this purpose, annual growth rate, compound growth rate and correlation coefficient for the period between 1995-2017 were used. According to the results of the analysis, it was found that there is a statistically significant positive relationship between oil price and GDP, oil production value and GDP for Iraqi economy.
Digital Technologies in Strategic Problems and Operational Tasks for Import Substitution of Oil and Gas Facilities
Authors: Kershenbaum V. , Guseva T. , Panteleev A.
Published: July 2019

An algorithm for improving technical standards for the import substitution objects has been proposed in the article. The requirements of standards are considered as data arrays, the processing of which in a certain way allows developing new standards for oil and gas equipment. These standards make it possible to improve the competitiveness of Russian technology. The use of digital technologies can significantly reduce time costs, increase the objectivity of the results of document comparison and increase the reasonableness of decision-making in the development of new standards. As a methodology for comparing normative databases, a cluster analysis of the standards’ requirements has been applied.
The Dynamics of Contact Interaction during the Cutting Process
Authors: Vasilkov Dmitriy V. , Nikitin Alexander V. , Tarikov Igor Y.
Published: July 2019

At parts manufacturing using metal-cutting machine tools, the process conditions eliminating high vibration levels are among the most important factors ensuring safe operation of the said metal-cutting machine tools. To solve the task, specific features typical for creation of the dynamic model of mechanical processing in the space of condition variables at contact interaction in the cutting zone based on the piecewise linear approximation were discussed. The contact interaction process was considered as the double-phase one envisaging sequence of retention at adhesion and sliding at adhesion bonds rupture. The cutting tool’ and the workpiece’ contact interactions are presented in the form of rheological models. Conditions of retention and sliding phases sequence are formed by the system itself that is the self-excited one. The set of research performed allowed considering contact interaction of the machined surface with the rear surface of the tool and the of the moving chip with the anterior surface of the tool with the anterior surface of the tool as factors largely defining the conditions of self-sustained oscillations. The contact interaction’ double-phase nature ensures self-organised dosing and selectiveness of the dynamic contours at interaction in the autonomous dynamic process system.
Taste Modulator Influences Rare Case of Color-Gustatory Synesthesia
Authors: Craver-Lemley Catherine , Reeves Adam
Published: July 2019

We investigated the effect of a sweetness blocker on the synesthetic taste experience of a rare color-gustatory synesthete, E.C., for whom specific colors elicit unique tastes. Blocking E.C.’s sweetness receptors while the tongue was otherwise unstimulated left other taste components of the synesthesia unaltered but initially reduced her synesthetic sweetness, which suggests a peripheral modulation of the synesthetic illusion.
Current State of Liver-Directed Therapies and Combinatory Approaches with Systemic Therapy in Hepatocellular Carcinoma (HCC)
Authors: Viveiros Pedro , Riaz Ahsun , Lewandowski Robert J. , Mahalingam Devalingam
Published: July 2019

The increasing set of liver-directed therapies (LDT) have become an integral part of hepatocellular carcinoma (HCC) treatment. These range from percutaneous ablative techniques to arterial embolization, and varied radiotherapy strategies. They are now used for local disease control, symptom palliation, and bold curative strategies. The big challenge in the face of these innovative and sometimes overlapping technologies is to identify the best opportunity of use. In real practice, many patients may take benefit from LDT used as a bridge to curative treatment such as resection and liver transplantation. Varying trans-arterial embolization strategies are used, and comparison between established and developing technologies is scarce. Also, radioembolization utilizing yttrium-90 (Y-90) for locally advanced or intermediate-stage HCC needs further evidence of clinical efficacy. There is increasing interest on LDT-led changes in tumor biology that could have implications in systemic therapy efficacy. Foremost, additional to its apoptotic and necrotic properties, LDT could warrant changes in vascular endothelial growth factor (VEGF) expression and release. However, trans-arterial chemoembolization (TACE) used alongside tyrosine-kinase inhibitor (TKI) sorafenib has had its efficacy contested. Most recently, interest in associating Y-90 and TKI has emerged. Furthermore, LDT-led differences in tumor immune microenvironment and immune cell infiltration could be an opportunity to enhance immunotherapy efficacy for HCC patients. Early attempts to coordinate LDT and immunotherapy are being made. We here review LDT techniques exposing current evidence to understand its extant reach and future applications alongside systemic therapy development for HCC.
Hypoxia Promotes Vascular Smooth Muscle Cell Proliferation through microRNA-Mediated Suppression of Cyclin-Dependent Kinase Inhibitors
Authors: Lee Jihui , Kang Hara
Published: July 2019

Regulation of vascular smooth muscle cell (VSMC) proliferation is essential to maintain vascular homeostasis. Hypoxia induces abnormal proliferation of VSMCs and causes vascular proliferative disorders, such as pulmonary hypertension and atherosclerosis. As several cyclin/cyclin-dependent kinase (CDK) complexes and CDK inhibitors (CKIs) control cell proliferation, in this study, we investigated CKIs involved in the hypoxia-induced proliferation process of human primary pulmonary artery smooth muscle cells to understand the underlying molecular mechanism. We demonstrated that p15, p16, and p21 are downregulated in pulmonary artery smooth muscle cells when exposed to hypoxia. In addition, we identified novel hypoxia-induced microRNAs (hypoxamiRs) including miR-497, miR-1268a, and miR-665 that are upregulated under hypoxia and post-transcriptionally regulate p15, p16, and p21 genes, respectively, by directly targeting their 3’UTRs. These miRNAs promoted the proliferation of VSMCs, and their inhibition decreased VSMC proliferation even in hypoxic conditions. Overall, this study revealed that miRNA-mediated regulatory mechanism of CKIs is essential for hypoxia-induced proliferation of VSMCs. These findings provide insights for a better understanding of the pathogenesis of vascular proliferative disorders.
Raman Spectra and Microstructure of Zinc Oxide irradiated with Swift Heavy Ion
Authors: Song Yin , Zhang Shengxia , Zhang Chonghong , Yang Yitao , Lv Kangyuan
Published: July 2019

Zinc oxide (ZnO) materials irradiated with 350 MeV 56Fe21+ ions were studied by Raman spectroscopy, Photoluminescence spectra (PL) and Transmission electron microscope (TEM). After 56Fe21+ ion irradiation, a strong oxygen vacancy (Vo) related defect absorption peak at 576 cm−1 and an interstitial zinc (Zni) -related defect at 80 cm−1~200 cm−1 formed, and with the increase of dose, the absorption peak was obviously enhanced. Through theoretical calculation, different Raman incident light test methods wereused to determine the oxygen vacancy defect (Vo). There were no significant variation tendencies in the other Raman characteristic lines. Our results demonstrate an energy loss process contributing to the defect structure during irradiation. TEM images showed a lot of fundamental defects. But we see no distinct amorphization in the samples in the electron diffraction images, indicating that the higher energy and irradiation dose hardly affected the structure and performance of zinc oxide.
Stability Analysis on Nonequilibrium Supersonic Boundary Layer Flow with Velocity-Slip Boundary Conditions
Authors: He Xin , Zhang Kai , Cai Chunpei
Published: July 2019

This paper presents our recent work on investigating velocity slip boundary conditions’ effects on supersonic flat plate boundary layer flow stability. The velocity-slip boundary conditions are adopted and the flow properties are obtained by solving boundary layer equations. Stability analysis of two such boundary layer flows is performed by using the Linear stability theory. A global method is first utilized to obtain approximate discrete mode values. A local method is then utilized to refine these mode values. All the modes in these two scenarios have been tracked upstream-wisely towards the leading edge and also downstream-wisely. The mode values for the no-slip flows agree well with the corresponding past results in the literature. For flows with slip boundary conditions, a stable and an unstable modes are detected. Mode tracking work is performed and the results illustrate that the resonance phenomenon between the stable and unstable modes is delayed with slip boundary conditions. The enforcement of the slip boundary conditions also shortens the unstable mode region. As to the conventional second mode, flows with slip boundary conditions can be more stable streamwisely when compared with the results for corresponding nonslip flows.
Body Image Concern and Eating Disorder Symptoms Among Elite Icelandic Athletes
Authors: Kristjánsdóttir Hafrún , Sigurðardóttir Petra , Jónsdóttir Sigurlaug , Þorsteinsdóttir Guðlaug , Saavedra Jose
Published: July 2019

The aim of this study was to analyse body image concerns and symptoms of eating disorders in elite Icelandic athletes according to their sex, and sport practiced. The participants were 755 athletes (24.8 ± 3.5 years in age) who compete at the highest possible level in Iceland. Representing 20 different sports, they were divided into five sports groups. Three questionnaires were used: the Body Shape Questionnaire to assess body image concerns; the Bulimia Test-Revised to assess the main symptoms of bulimia; and the Eating Disorder Examination Questionnaire to identify disordered eating attitudes and behaviours. A chi-squared test was used to analyse differences in prevalence of body image concern and eating disorders, a t-test for the differences between men and women, and a one-way ANOVA to compare the different sports. The main findings were that 17.9% of the athletes presented severe or moderate body image dissatisfaction, and 18.2% (25.3% of the women) were above the clinical cutoff for body image concern. Women’s scores were higher than men’s (whole sample and ball games) in all variables except restraint. These results seem to point to the existence of a real problem that athlete, coaches, doctors, and institutions need to take into account.
Effect of Hybrid Power Station Installation in the Operation of Insular Power Systems
Authors: Bouzounierakis Nikolaos , Katsigiannis Yiannis , Fiorentzis Konstantinos , Karapidakis Emmanuel
Published: July 2019

Greece has a large number of islands that are isolated from the main interconnected Greek power system; however, a majority of them are to be interconnected in the mainland grid over the next decade. A large number of these islands present a significant amount of wind and solar potential. The nature of load demand and renewable production is stochastic; thus, the operation of such isolated power systems can be improved significantly by the installation of a large-scale energy storage system. The role of storage is to compensate for the long and short-term imbalances between power generation and load demand. Pumped hydro storage (PHS) systems represent one of the most mature technologies for large-scale energy storage. However, their advantages have not been proven in practice for cases of medium and small-sized isolated insular systems. Regarding Greece, which contains a large number of isolated insular systems, a PHS system in the island of Ikaria started its test operation in 2019, whereas in Europe only one PHS system operates in El Hierro (Canary Islands). This paper studies the effect of installing a wind-PHS hybrid power station in the operation of the insular power system of Samos, Greece, according to the latest regulatory framework. The implemented analysis uses real hourly data for a whole year, and examines the effects of such an installation considering investors’ and power system operators’ viewpoints. More specifically, the economic viability of this project under different billing scenarios is compared, and its impact on the insular power system operation for various PHS sizes is examined.
A Simple Effective Pharmacological Treatment of Hypoxemia During One-Lung Ventilation
Authors: Chiumello Davide , Coppola Silvia , Ferrari Erica
Published: July 2019

Hypoxemia during one-lung ventilation is a challenge in the clinical practice. Moving from the results of the study conducted by Choi et al., we discuss the possibility to modulate hypoxemia by administering iloprost via inhalation, in the light of the physiological mechanisms.
Cohen-Macaulay and (S2) Properties of the Second Power of Squarefree Monomial Ideals
Authors: Hoang Do Trong , Rinaldo Giancarlo , Terai Naoki
Published: July 2019

We show that Cohen-Macaulay and (S 2 ) properties are equivalent for the second power of an edge ideal. We give an example of a Gorenstein squarefree monomial ideal I such that S / I 2 satisfies the Serre condition (S 2 ), but is not Cohen-Macaulay.
Peptide-Based Subunit Vaccine Design of T- and B-Cells Multi-Epitopes against Zika Virus Using Immunoinformatics Approaches
Authors: Prasasty Vivitri Dewi , Grazzolie Karel , Rosmalena Rosmalena , Yazid Fatmawaty , Ivan Fransiskus Xaverius , Sinaga Ernawati
Published: July 2019

The Zika virus disease, also known as Zika fever is an arboviral disease that became epidemic in the Pacific Islands and had spread to 18 territories of the Americas in 2016. Zika virus disease has been linked to several health problems such as microcephaly and the Guillain–Barré syndrome, but to date, there has been no vaccine available for Zika. Problems related to the development of a vaccine include the vaccination target, which covers pregnant women and children, and the antibody dependent enhancement (ADE), which can be caused by non-neutralizing antibodies. The peptide vaccine was chosen as a focus of this study as a safer platform to develop the Zika vaccine. In this study, a collection of Zika proteomes was used to find the best candidates for T- and B-cell epitopes using the immunoinformatics approach. The most promising T-cell epitopes were mapped using the selected human leukocyte antigen (HLA) alleles, and further molecular docking and dynamics studies showed a good peptide-HLA interaction for the best major histocompatibility complex-II (MHC-II) epitope. The most promising B-cell epitopes include four linear peptides predicted to be cross-reactive with T-cells, and conformational epitopes from two proteins accessible by antibodies in their native biological assembly. It is believed that the use of immunoinformatics methods is a promising strategy against the Zika viral infection in designing an efficacious multiepitope vaccine.
Hypotensive Snake Venom Components—A Mini-Review
Authors: Péterfi Orsolya , Boda Francisc , Szabó Zoltán , Ferencz Elek , Bába László
Published: July 2019

Hypertension is considered a major public health issue due to its high prevalence and subsequent risk of cardiovascular and kidney diseases. Thus, the search for new antihypertensive compounds remains of great interest. Snake venoms provide an abundant source of lead molecules that affect the cardiovascular system, which makes them prominent from a pharmaceutical perspective. Such snake venom components include bradykinin potentiating peptides (proline-rich oligopeptides), natriuretic peptides, phospholipases A2, serine-proteases and vascular endothelial growth factors. Some heparin binding hypotensive factors, three-finger toxins and 5′ nucleotidases can also exert blood pressure lowering activity. Great advances have been made during the last decade regarding the understanding of the mechanism of action of these hypotensive proteins. Bradykinin potentiating peptides exert their action primarily by inhibiting the angiotensin-converting enzyme and increasing the effect of endogenous bradykinin. Snake venom phospholipases A2 are capable of reducing blood pressure through the production of arachidonic acid, a precursor of cyclooxygenase metabolites (prostaglandins or prostacyclin). Other snake venom proteins mimic the effects of endogenous kallikrein, natriuretic peptides or vascular endothelial growth factors. The aim of this work was to review the current state of knowledge regarding snake venom components with potential antihypertensive activity and their mechanisms of action.
A Structure—Activity Relationship Study of Bis-Benzamides as Inhibitors of Androgen Receptor—Coactivator Interaction
Authors: Lee Tae-Kyung , Ravindranathan Preethi , Sonavane Rajni , Raj Ganesh V. , Ahn Jung-Mo
Published: July 2019

The interaction between androgen receptor (AR) and coactivator proteins plays a critical role in AR-mediated prostate cancer (PCa) cell growth, thus its inhibition is emerging as a promising strategy for PCa treatment. To develop potent inhibitors of the AR–coactivator interaction, we have designed and synthesized a series of bis-benzamides by modifying functional groups at the N/C-terminus and side chains. A structure–activity relationship study showed that the nitro group at the N-terminus of the bis-benzamide is essential for its biological activity while the C-terminus can have either a methyl ester or a primary carboxamide. Surveying the side chains with various alkyl groups led to the identification of a potent compound 14d that exhibited antiproliferative activity (IC50 value of 16 nM) on PCa cells. In addition, biochemical studies showed that 14d exerts its anticancer activity by inhibiting the AR–PELP1 interaction and AR transactivation.
Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease
Authors: Toublet François-Xavier , Lecoutey Cédric , Lalut Julien , Hatat Bérénice , Davis Audrey , Since Marc , Corvaisier Sophie , Freret Thomas , Sopkova de Oliveira Santos Jana , Claeysen Sylvie , Boulouard Michel , Dallemagne Patrick , Rochais Christophe
Published: July 2019

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease which is still poorly understood. The drugs currently used against AD, mainly acetylcholinesterase inhibitors (AChEI), are considered clinically insufficient and are responsible for deleterious side effects. AChE is, however, currently receiving renewed interest through the discovery of a chaperone role played in the pathogenesis of AD. But AChE could also serve as an activating protein for pleiotropic prodrugs. Indeed, inhibiting central AChE with brain-penetrating designed carbamates which are able to covalently bind to the enzyme and to concomitantly liberate active metabolites in the brain could constitute a clinically more efficient approach which, additionally, is less likely to cause peripheral side effects. We aim in this article to pave the road of this new avenue with an in vitro and in vivo study of pleiotropic prodrugs targeting both the 5-HT4 receptor and AChE, in order to display a neuroprotective activity associated with a sustained restoration of the cholinergic neurotransmission and without the usual peripheral side effects associated with classic AChEI. This plural activity could bring to AD patients effective, relatively safe, symptomatic and disease-modifying therapeutic benefits.
Long-Chain Polyisoprenoids Are Synthesized by AtCPT1 in Arabidopsis thaliana
Authors: Surowiecki Przemyslaw , Onysk Agnieszka , Manko Katarzyna , Swiezewska Ewa , Surmacz Liliana
Published: July 2019

Arabidopsis roots accumulate a complex mixture of dolichols composed of three families, (i.e., short-, medium- and long-chain dolichols), but until now none of the cis-prenyltransferases (CPTs) predicted in the Arabidopsis genome has been considered responsible for their synthesis. In this report, using homo- and heterologous (yeast and tobacco) models, we have characterized the AtCPT1 gene (At2g23410) which encodes a CPT responsible for the formation of long-chain dolichols, Dol-18 to -23, with Dol-21 dominating, in Arabidopsis. The content of these dolichols was significantly reduced in AtCPT1 T-DNA insertion mutant lines and highly increased in AtCPT1-overexpressing plants. Similar to the majority of eukaryotic CPTs, AtCPT1 is localized to the endoplasmic reticulum (ER). Functional complementation tests using yeast rer2Δ or srt1Δ mutants devoid of medium- or long-chain dolichols, respectively, confirmed that this enzyme synthesizes long-chain dolichols, although the dolichol chains thus formed are somewhat shorter than those synthesized in planta. Moreover, AtCPT1 acts as a homomeric CPT and does not need LEW1 for its activity. AtCPT1 is the first plant CPT producing long-chain polyisoprenoids that does not form a complex with the NgBR/NUS1 homologue.
Novel Non-Metal Cation (NMC) Pentaborate Salts of Some Amino Acids
Authors: Sızır Ümit , Yurdakul Ömer , Köse Dursun Ali , Akkurt Fatih
Published: July 2019

Non-metal cation (NMC) pentaborate structures, in which some amino acids (valine, leucine, isoleucine, and threonine) were used as cations, were synthesized. The structural characterization of molecules was carried out by elemental analysis, FT-IR, mass, 11B-NMR, and thermal analysis (TGA/DTA) methods. The hydrogen storage capacity of molecules was also calculated by taking experimental results into consideration. The FT-IR spectra support the similarity of structures. The characteristic peaks attributable to pentaborate rings and amino acids were observed. When thermal analysis data were examined, it was observed that pentaborate salts gave similar degradation steps and degradation products. As a final degradation product of all thermal analysis experiments, a glassy form of B2O3 was observed. The valine pentaborate is the most thermally stable. Also, the amounts of hydrate water outside the coordination sphere of the compounds were determined by thermal analysis curves. The peaks of boric acid, triborate, and pentaborate structures were obtained in ppm with the 11B-NMR results of synthesized pentaborate compounds. With powder X-ray spectroscopy, all structures were found to be crystalline but not suitable for single-crystal X-ray analysis. The molecular cavities of the compounds detected by BET were found to be 3.286, 1.873, 2.309, and 1.860 g/cm3, respectively. A low number of molecular cavities can be interpreted in several existing hydrogen bonds in structures. The hydrogen storage capacities of the molecules were found to be in the range of 0.04 to 0.07% by mass.
Nanoscale Heat Conduction in CNT-POLYMER Nanocomposites at Fast Thermal Perturbations
Authors: Minakov Alexander A. , Schick Christoph
Published: July 2019

Nanometer scale heat conduction in a polymer/carbon nanotube (CNT) composite under fast thermal perturbations is described by linear integrodifferential equations with dynamic heat capacity. The heat transfer problem for local fast thermal perturbations around CNT is considered. An analytical solution for the nonequilibrium thermal response of the polymer matrix around CNT under local pulse heating is obtained. The dynamics of the temperature distribution around CNT depends significantly on the CNT parameters and the thermal contact conductance of the polymer/CNT interface. The effect of dynamic heat capacity on the local overheating of the polymer matrix around CNT is considered. This local overheating can be enhanced by very fast (about 1 ns) components of the dynamic heat capacity of the polymer matrix. The results can be used to analyze the heat transfer process at the early stages of “shish-kebab” crystal structure formation in CNT/polymer composites.
SnO2 Films Deposited by Ultrasonic Spray Pyrolysis: Influence of Al Incorporation on the Properties
Authors: Deyu Getnet Kacha , Muñoz-Rojas David , Rapenne Laetitia , Deschanvres Jean-Luc , Klein Andreas , Jiménez Carmen , Bellet Daniel
Published: July 2019

Aluminum-doped tin oxide (SnO 2 :Al) thin films were produced by an ultrasonic spray pyrolysis method. The effect of aluminum doping on structural, optical, and electrical properties of tin oxide thin films synthesized at 420 ° C was investigated. Al doping induced a change in the morphology of tin oxide films and yielded films with smaller grain size. SnO 2 thin films undergo a structural reordering and have a texture transition from (301) to (101), and then to (002) preferred cristallographic orientation upon Al doping. The lattice parameters (a and c) decreases with Al doping, following in a first approximation Vegard’s law. The optical transmission does not change in the visible region with an average transmittance value of 72–81%. Conversely, in the near infrared (NIR) region, the plasmon frequency shifts towards the IR region upon increasing Al concentration in the grown films. Nominally undoped SnO 2 have a conductivity of ∼1120 S/cm, which is at least two orders of magnitude larger than what is reported in literature. This higher conductivity is attributed to the Cl − ions in the SnCl 4 ·5(H 2 O) precursor, which would act as donor dopants. The introduction of Al into the SnO 2 lattice showed a decrease of the electrical conductivity of SnO 2 due to compensating hole generation. These findings will be useful for further studied tackling the tailoring of the properties of highly demanded fluorine doped tin oxide (FTO) films.
Antityrosinase, Antioxidant, and Cytotoxic Activities of Phytochemical Constituents from Manilkara zapota L. Bark
Authors: Chunhakant Sutthiduean , Chaicharoenpong Chanya
Published: July 2019

Hyperpigmentation is considered by many to be a beauty problem and is responsible for photoaging. To treat this skin condition, medicinal cosmetics containing tyrosinase inhibitors are used, resulting in skin whitening. In this study, taraxerol methyl ether (1), spinasterol (2), 6-hydroxyflavanone (3), (+)-dihydrokaempferol (4), 3,4-dihydroxybenzoic acid (5), taraxerol (6), taraxerone (7), and lupeol acetate (8) were isolated from Manilkara zapota bark. Their chemical structures were elucidated by analysis of their nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) data, and by comparing them with data found in the literature. The in vitro antityrosinase, antioxidant, and cytotoxic activities of the isolated compounds (1–8) were evaluated. (+)-Dihydrokaempferol (4) exhibited higher monophenolase inhibitory activity than both kojic acid and α-arbutin. However, it showed diphenolase inhibitory activity similar to kojic acid. (+)-Dihydrokaempferol (4) was a competitive inhibitor of both monophenolase and diphenolase activities. It exhibited the strongest 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP) activities of the isolated compounds. Furthermore, (+)-dihydrokaempferol (4) also demonstrated potent cytotoxicity in breast carcinoma cell line (BT474), lung bronchus carcinoma cell line (Chago-K1), liver carcinoma cell line (HepG2), gastric carcinoma cell line (KATO-III), and colon carcinoma cell line (SW620). These results suggest that M. zapota bark might be a good potential source of antioxidants and tyrosinase inhibitors for applications in cosmeceutical products.
TiVZrNb Multi-Principal-Element Alloy: Synthesis Optimization, Structural, and Hydrogen Sorption Properties
Authors: Montero Jorge , Zlotea Claudia , Ek Gustav , Crivello Jean-Claude , Laversenne Lætitia , Sahlberg Martin
Published: July 2019

While the overwhelming number of papers on multi-principal-element alloys (MPEAs) focus on the mechanical and microstructural properties, there has been growing interest in these alloys as solid-state hydrogen stores. We report here the synthesis optimization, the physicochemical and the hydrogen sorption properties of Ti0.325V0.275Zr0.125Nb0.275. This alloy was prepared by two methods, high temperature arc melting and ball milling under Ar, and crystallizes into a single-phase bcc structure. This MPEA shows a single transition from the initial bcc phase to a final bct dihydride and a maximum uptake of 1.7 H/M (2.5 wt%). Interestingly, the bct dihydride phase can be directly obtained by reactive ball milling under hydrogen pressure. The hydrogen desorption properties of the hydrides obtained by hydrogenation of the alloy prepared by arc melting or ball milling and by reactive ball milling have been compared. The best hydrogen sorption properties are shown by the material prepared by reactive ball milling. Despite a fading of the capacity for the first cycles, the reversible capacity of the latter material stabilizes around 2 wt%. To complement the experimental approach, a theoretical investigation combining a random distribution technique and first principle calculation was done to estimate the stability of the hydride.
PENGARUH TOTAL ASSET TURN OVER (TATO) DAN EARNING PER SHARE (EPS) TERHADAP RETURN SAHAM PADA PERUSAHAAN FOOD AND BEVERAGE YANG TERDAFTAR DI BEI PERIODE 2012-2016
Authors: Maiyaliza Maiyaliza
Published: July 2019

This research aims to determine the effect of each a Total Asset Turn Over (TATO) and Earning Per Share (EPS) of the Stock Return on Food and Beverage companies registered in the Indonesian Stock Exchange (BEI) in the period 2012-2016. This research was conducted using secondary data. Sample selection technique used is purposive sampling technique, from 14 companies only taken eight companies that match the criteria used. The analytical method used is simple linear regression analysis and multiple linear regression analysis. The results of this study have fulfilled classical assumption test. This research also used  hypothesis test the are partial test and simultaneous test. Data were analyzed using SPSS 23:00 for windows. From the regression results indicate that the Total Asset Turn Over (TATO) and Earning Per Share (EPS) respectively no significant effect on Stock Return and jointly Total Asset Turn Over ( TATO ) and Earning Per Share ( EPS ) respectively no significant effect on Stock Return .                                                                                     

Keywords : Total Asset Turn Over, earning Per Share, Stock Return
KEMITRAAN PEMERINTAH KOTA, LEMBAGA PERBANKAN DAN WAJIB PAJAK DALAM PEMBAYARAN PAJAK BUMI DAN BANGUNAN DI KOTA CIMAHI
Authors: Candradewini Candradewini , Kurniati Poni Sukaesih
Published: July 2019

Central government policy delegates the management of Land and Urban Building Tax (PBB-P) requires local governments to improve themselves. This is to optimize the acceptance of the tax as the Local Revenue (PAD). This study aims to explain the partnership built by Cimahi City Revenue Service with Banking Institution and taxpayers in performing the payment of land and urban building tax in CImahi City. The research method used qualitative approach. This approach is intended to reveal the phenomenon of partnership woven by the parties that are partnering Department of Revenue, Banking and Society. Informants in this study is the head of the Revenue Service. Representatives of banking and public taxpayers namely the land and urban building tax. To ensure the validity of data used triangulation technique. The results show that in general the partnership works well is evidenced by the increased acceptance of tax and better communication among the partners. Taxpayers awareness to make payments through banks also increases. It also shows the quality of partnership achieving the expected results.

Keywords: partnership, goverment, banking, taxpayers
PENCAPAIAN KEPUASAN KERJA MELALUI PENILAIAN KINERJA KARYAWAN DAN EFIKASI DIRI PADA KOPERASI PT INDUSTRI TELEKOMUNIKASI INDONESIA BANDUNG
Authors: Suyudi Muriawan Suyudi Muriawan , Sandewi Risan
Published: July 2019

Economic development affects the increasingly difficult society, all activities in an organization or from the company one of them is to manage its employees, job satisfaction is one thing that is closely related to employees. Job satisfaction can be measured through self-efficacy and employee performance Assessment. The purpose of this study to find out how much influence Employee Performance Assessment of job satisfaction at Cooperative Inti Bandung and how much influence self-efficacy on job satisfaction at Cooperative of PT Inti Bandung. The method of analysis in this study using descriptive and verification analysis. Unit in this research is employees of Cooperative Inti which amounted to 31 respondents as population. The sampling technique used in this research is saturated or census sampling so that the number of samples in this study were 31 respondents from the total population of employees. Data collection techniques through questionnaires, interviews and observations. The method of analysis using multiple linear regression analysis with partial hypothesis testing using T and simultaneous test using F test. Based on the results of descriptive research that shows that the assessment of employee performance on the category is very good enough, and self-efficacy is good enough, and job satisfaction is satisfactory. The result of verification research stated that job satisfaction can be determined by employee performance assessment and self-efficacy. In addition, the coefficient analysis of self-efficacy determination more influence on job satisfaction in comparison with the assessment of employee performance in Cooperative Inti Bandung.
IMPLEMENTASI AUDIT BERBASIS RESIKO DAN DUE PROFESIONAL CARE YANG DIMILIKI AUDITOR BERDAMPAK PADA KUALITAS AUDIT
Authors: SE.,M.Si Surtikanti , Saleh Dean Subhan
Published: July 2019

ABSTRACT

Due professional care and work experience are the most important to be have by auditor. The auditor must have due professional care and work experience to produce a good financial report. If auditor have a good due professional care and work experience, then the quality of audit will be good. Due professional care and work experience will affect the quality of audit. But in fact, the quality of audit produced bay auditor is not good enough. The purpose of this research is the effect of due professional care and work experienceto quality of audit survey on KAP existing in Bandung.

The method used in this research is descriptive method, verification with quantitative approach. Descriptive method used to determine due professional care and work experience to quality of audit. The test statistic used is the calculation of validity and relibility testing using software SPSS 18.0 for windows. For verification method using SEM PLS, evaluation results outer model by value loading factor and discrimination validity. All the indicators used in this research is valid and able to measure latent variables.

The result from this research indicate that due professional care has a significant impact on the quality of audit that if due professional care great then the resulting quality of audit would be great, while work experience has a significant impact on the quality of audit that if work experience is good then the quality of audit would be good.

 

Keywords : Due Professional Care, Risk Audit, and Quality of Audit
PENGARUH BUDAYA ORGANISASI DAN TEKNOLOGI INFORMASI TERHADAP KUALITAS SISTEM INFORMASI AKUNTANSI PADA PT. INTI (PERSERO)
Authors: Astuti Ayi , Pinasti Erina , Bramasto Ari
Published: July 2019

Penelitian ini bertujuan untuk mengetahui adanya pengaruh budaya organisasi dan teknologi iinformasi terhadap kualitas sistem informasi akuntansi. dalam penelitian yang dijadikan populasi adalah karyawan bagian HCM dan Quality, corporate finance, satuan pengendalian internal, pengembangan bisnis dan produk, SBU broadband pada PT INTI (Persero) Bandung. teknik dalam penelitian ini menggunakan metode purposie sampling berjumla 43 responden yang terdiri dari manager dan staff bagian HCM dan Quality corporate finance, satuan pengendalian internal, pengembangan bisnis dan produk SBU broadband, data yang digunakan adalah data primer dan penelitian ini menggunakan metode analisis data yaitu metode deskriptif dan metode verifikatif dengan pendekatan kuantitatif. teknik pengumpulan data menggunakan penyebaran kuesioner secara langsung pada perusahaan PT. INTI (Persero). uji statistik yang digunakan pada penelitian ini adalah uji validitas, uji reliabilitas, analisis jalur, uji analisis koefisien korelasi, uji standar koefisien, dan uji T, diolah secara statistik menggunakan program SPSS versi 23.

Hasil penelitian ini membuktikan bahwa : 1) aBudaya organisasi berpengaruh signiikan terhadap kualitas sistem informasi akuntansi, 2) teknologi informasi berpengaruh signiikan teradap kualitas sistem inormasi akuntansi.

Kata Kunci : Budaya Organisasi, Teknologi Informasi, dan Kualitas Sistem Informasi
Main Training Tasks and Activity of the ISS crews for Expedition 56/57 When Carrying out the Mission Plan
Authors: Prokopiev Sergey Valerievich
Published: July 2019

The paper presents the composition of the ISS-56/57 crew, main objectives of training, activity of the crew aboard the “Soyuz MS-09” TMV and International Space Station (ISS). Extravehicular activity under programs of the Russian Segment (RS) and the US Orbital Segment (USOS) of the ISS as well as implementing science applied research (SAR) and experiments (SAR) are given separately.
A New Variety of Anthurium clavigerum (Araceae) from Sucre Department, Colombia
Authors: Carrascal Prasca Dairo , Herazo Vitola Fran , Croat Thomas B.
Published: July 2019

Anthurium clavigerum Poepp. var. corazaense Croat, Carrascal & Herazo is described as a new variety of A. clavigerum, a member of section Dactylophyllium (Schott) Engl. It is found in the Reserva Forestal Protectora Serranía de Coraza in the Department of Sucre, Colombia.
Two New Species of Madagascan Claoxylon (Euphorbiaceae, Acalyphoideae) and a Key to the Species of Madagascar and the Comoro Islands
Authors: McPherson Gordon
Published: July 2019

Two new species of Madagascan Claoxylon A. Juss. are described, and a key to the resulting 12 species now considered to occur on Madagascar and the Comoro Islands is presented. Claoxylon ambrense McPherson is distinguished by its combination of exstipellate, oblanceolate, abruptly acuminate leaves bearing only unpaired hairs, and pistillate flowers with sepals 1–2 mm long and suborbicular disk glands. Claoxylon stylosum McPherson is characterized by its combination of large, ovate, densely pubescent, typically cordate leaves and pistillate flowers with long stylodia (3–3.5 mm), which are fused nearly half their total length. As well, C. medullosum Baill. is relegated to the synonymy of C. monoicum Baill.