bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of mulch on soil pH and the growth of vanilla plants (Vanilla planifolia) in short-term greenhouse and agroforestry plantation experiments
Authors: Adiputra I Gede Ketut
Published: May 2022

Agroforestry produces various types of waste that can lower soil pH, increase the negative effect of allelochemicals and inhibit the growth of vanilla plants. Studies were conducted to examine the short-term effect (43 to 85 days) of dry and fresh mulches, compost and charcoal on soil pH and the growth of vanilla plants. Studies were performed in an agroforest and in a greenhouse using a completely randomised experimental design. The studies found that during rainy season in the agroforest, the addition of fresh grass clippings decreased soil pH by 0.15 relative control. In contrast, the same addition increased soil pH in greenhouse experiments by 0.22. The addition of compost also decreased soil pH in agroforestry by 0.15 but increased pH in greenhouse by 0.20. A similar effect was also found after the addition of charcoal. The addition of coconut husks and leaf litter in agroforest led to similar soil pH as the control, at 6.0 and 6.42 for coconut husks and leaf litter, respectively. High growth of vanilla plants occurred in a soil pH range from 6.0 to 6.5, irrespective of mulch materials added. This study indicates that environmental conditions change soil-mulch interactions, and that vanilla plants thrive well in soil pH ranging from 6.0 to 6.5 in most of the mulch types tested
Understanding the flux of nitrous oxide from the eucalypt soil in monoculture and Integrated Crop–Livestock–Forest systems
Authors: Silveira Júlia Graziela da , Wink Charlote , Cesário Fernando Vieira , Armacolo Natassia Magalhães , Nogueira Anna Karolyne da Silva , Silva Jacqueline Jesus Nogueira da , Leite Fernanda Figueiredo Granja Dorilêo , Conceição Marcela Cardoso Guilles da , Neto Silvio Nolasco de Oliveira , Rodrigues Renato de Aragão Ribeiro
Published: May 2022

The Brazilian agricultural sector is largely responsible for nitrous oxide (N2O) soil emissions, mainly due to beef cattle and the use of synthetic nitrogen fertilizers. Therefore, Brazil is looking for measures, such as integrated crop–livestock– forest (ICLF), to increase productivity and reduce greenhouse gas emissions in this sector. The forest component within this system plays a positive role in the context of climate change, soil conservation, carbon dioxide (CO2) sequestration, and biodiversity protection. The aim of this study was to evaluate the effect of management and rainfall on N2O emissions in eucalypt monoculture soils and eucalypt soils in ICLF systems. Manual static chambers were used to collect gas samples, from November 2013 to October 2014, in four treatments, i.e., one eucalypt monoculture (F) and three modalities of ICLF (livestock–forest [LF], livestock–crop–forest [LCF], and integrated crop–livestock–forest [ICLF]). A gas chromatograph with an electron capture detector was used to measure the N2O concentrations. The results showed that rainfall considerably affected N2O fluxes across all the treatments, indicating that rainfall is the main factor in increasing emissions. During the wet season, the N2O levels ranged from 0.158 to 0.482 kg N-N2O ha-1 across all treatments. During the dry season, all treatments behaved like sinks of N2O. Moreover, N2O flux did not differ between the soils in the eucalypt monoculture and ICLF systems. This indicates that the forestry component in the ICLF systems did not affect N2O soil fluxes.
Influence of bentonite adsorbents associated with hepatic antioxidants on the health and production of dairy cows fed diets containing naturally produced mycotoxins
Authors: Domenico Dalvane Di , Oliveira Mirodion Santos , Garbossa Gabriela , Thomaz Gabriela Rodrigues , Abreu Ana Carolina Araujo , Depaoli Carolina Rodrigues , Ornaghi Mariana Garcia , Stuani Osmair Flavio , Bertagnon Heloísa Godoi
Published: May 2022

As mycotoxins are consistent contaminants in the dairy cow diet, the use of adsorbents is recommended, although there are no ideal adsorbents. Although there are studies on this subject, few have focused on chronic natural intoxications. Here, we evaluated the effect of bentonite adsorbents associated with liver antioxidants on the health and milk production of dairy cows fed a diet containing naturally-produced fumonisin, zearalenone, and deoxynivalenol. Eighteen dairy cows (bodyweight 550 ±50 kg, 5 ± 2 years old, and 30 ± 1,25 kg/day milk production) in the middle of lactation were divided into groups: treatment (TG, n = 9, 22 g/day of supplement added to diet) and control (CG, n = 9, without supplement). A physical examination was performed, weekly over 56 days and blood was collected for liver and immune assessments. Milk was harvested to evaluate milk production and content (fat protein, somatic cell count, and lactose). The additive promoted beneficial effects on the liver from the 24th day due to a decrease in the enzymatic activities of gamma-glutamyltransferase and lactate dehydrogenase and increased serum protein and albumin levels. There were improvements in health, evidenced as fewer clinical manifestations of the disease, greater leukocyte oxidative metabolism capacity, and a lower neutrophil lymphocytes ratio. The treatment also promoted a 19% increase in milk volume. It was concluded that the additive promoted health benefits and milk production in dairy cows.
Quality assessment of amazonian fish from fish farming stored on ice
Authors: Silva Shadai Mendes , Ramirez Juan Rafael Buitrago , Silva Shekinah Mendes , Dantas Filho Jerônimo Vieira , Marmentini Regiane Pandolfo , Schons Sandro de Vargas , Cavali Jucilene
Published: May 2022

The cultivation of natives Amazonian fish such as tambaqui (Colossoma macropomum), pirapitinga (Piaractus brachypomus), tambatinga (female, Colossoma macropomum X Piaractus brachypomus, male) and Pintando da Amazônia (female, Pseudoplatystoma sp. X Leiarius marmoratus, male) temmoratus, increased in recent years, making studies related to the validity of these foods after processing necessary. Therefore, the aimed of the study was to evaluate the sensory, microbiological (Staphylococcus coagulase positive count and presence of Salmonella spp.) and chemical (pH and Total Volatile Bases (TVB) quality of fresh gutted fish stored on ice. Nine specimens of each species were used, all cultivated in an excavated tanks. The fasting time ranged from 16 to 48 hours, depending on the species, the fish was slaughtered by means of cold shock. The fish was gutted and stored in the fish fridge. Sensory analysis was performed by a trained team available. For other analyses, it was sent to a laboratory specializing in food analysis. The sensory analysis of fresh eviscerated tambaqui was characteristic of the species until the 15th day of storage. Fresh eviscerated pirapitinga presented until the 16th day. The fresh eviscerated tambatinga hybrid was kept until the 14th day of storage. And for the Pintado da Amazônia, the organoleptic characteristics were presentable until the 12th day of storage. The microbiological and physical-chemical analyzes were in accordance with Brazilian legislation in all specimens of the analyzed species. It was observed that the longer the fasting period, there was a numerical increase in the pH of the fish meat.
Main risk factors of dogs with congestive heart failure diagnosed by doppler echocardiographic parameters
Authors: Nunes Bruna Pereira , Prado Marina Gabriela Ferreira , Romão Luciene Maria Martinello , Romão Felipe Gazza
Published: May 2022

Nowadays, congestive heart failure is one of the major complications of heart disease in small animals, which is characterized by a clinical condition in which the heart is unable to eject the blood efficiently. At long term, some compensatory mechanisms it will eventually become detrimental and, mainly, due to the congestion caused by it. In dogs, the main cause of CHF is chronic mitral valve degeneration, it is responsible for the degeneration of collagen present in the mitral valve structure that will have detrimental consequences on the entire circulatory system. The aim of the present study was to perform a retrospective study of 498 echocardiographic reports collected at a veterinary cardiology service of the Bauru region, from January 2017 to June 2019. Two groups were formed according to the Doppler echocardiographic alterations found, one that included animals with characteristics of congestive heart failure (CHF), and the other formed by non-CHF patients. Of the total number of animals evaluated, 61 were classified as affected by congestive heart failure and after classification, it was considered the main epidemiological factors (race, sex and age) of animals belonging to this group. Small breed animals were overrepresented and also elderly animals, with no apparent sexual predisposition. In addition, animals with CHF presented higher values when compared to animals without CHF of LA/Ao ratio (2.31 ± 0.30 vs. 1.46 ± 0.35), E/IRTV ratio (2.96 ± 0.39 vs. 1.16 ± 0.43) and E-wave velocity (1.45 m/s ± 0.18 vs. 0.75 m/s ± 0.22) on echocardiographic examination.
Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction
Authors: Kamath Mohan S. , Kamath Vandana , Chacko Mary Purna
Published: May 2022

In the decade since non-invasive prenatal testing (NIPT) was first implemented as a prenatal
screening tool, it has gained recognition for its sensitivity and specificity in the detection of common
aneuploidies. This review mainly focuses on the emerging role of NIPT in pregnancies following
assisted reproductive technology (ART) in the light of current evidence and recommendations. It also
deals with the challenges, shortcomings and interpretational difficulties related to NIPT in ART pregnancies,
with particular emphasis on twin and vanishing twin pregnancies, which are widely regarded
as the Achilles’ heel of most pre-natal screening platforms. Future directions for exploration towards
improving the performance and extending the scope of NIPT are also addressed.
Outpatient Use of Electrical Impedance Tomography in Patients with
Chronic Obstructive Pulmonary Disease: A Scoping Review
Authors: Benavides-Cordoba Vicente , Medina Diana Quintero , Luna Esther Cecilia Wilches
Published: May 2022

Objective:

Electrical Impedance Tomography (EIT) has emerged as a non-invasive, radi-ation-free imaging modality that allows monitoring at the patient's bedside, providing real-time in-formation on the regional distribution of pulmonary ventilation. Although there has been increasing research on EIT in Intensive Care Units (ICUs), few studies use this tool in patients with spontane-ous breathing. The objective is to describe the current evidence regarding the outpatient use of EIT in patients with chronic obstructive pulmonary disease (COPD).

Methods:

A scoping review was performed. An extensive search was conducted in seven health-based databases, Scopus, Medline, OVID, Scielo, PEDro, EBSCO, and VHL search portal. In this scoping review, the checklist recommended by PRISMA was used. To assess the quality of the studies, the BEME protocol of "questions to ask about the evidence of an investigation or evalua-tion" was used.

Results:

In this scoping review, 7 studies published between 2009 and 2019 related to the outpatient use of EIT in COPD patients were identified. The evidence reviewed allowed us to identify that the frequent use is related to the evaluation of the distribution of ventilation, the evaluation of regional respiratory mechanics, and the degree of pre- and post-bronchodilator obstruction.

Conclusion:

EIT is used on an outpatient basis in patients with COPD as an evaluation tool that complements the information regarding the clinical results of pulmonary function tests, improving the monitoring of the course of the disease in real-time, non-invasively, and without ionizing radiation.
Predictors of Early Pregnancy Fatigue among Iranian Women during the
COVID-19 Pandemic: A Cross Sectional Study
Authors: Veisy Afsaneh , Charandabi Sakineh Mohammad Alizadeh , Abbas-Alizadeh Shamci , Ghaderi Fariba , Haghighi Mahmonir , Mirghafourvand Mojgan
Published: May 2022

Background:

Fatigue is a common problem in pregnancy and is associated with negative
outcomes.

Objective:

This study aimed to determine the predictors of fatigue in pregnant women.

Methods:

This cross-sectional study was conducted on 150 pregnant women with a gestational age
of 12-18 weeks visiting the healthcare centers in Mahabad-Iran, 2021. Fatigue was assessed via the
modified Multidimensional Assessment of Fatigue (MAF) checklist, depression via the Edinburgh
Postnatal Depression Scale (EPDS), stress and anxiety via Depression, Anxiety and Stress Scale-21
(DASS-21), well-being via WHO-5, and positive and negative affect via International Positive and
Negative Affect Schedule-Short Form (I-PANAS-SF). The general linear model was used to estimate
the degree of the effect of each independent variable (sociodemographic characteristics, depression,
stress, anxiety, positive and negative affect, and well-being) on the dependent variable
(early pregnancy fatigue).

Results:

The mean (SD) fatigue score was 21.91 (7.07), within the 0-50 possible range. The majority
of pregnant women (87.3%) suffered from fatigue. Based on the Pearson or Spearman correlation
analysis, a significant correlation was observed between fatigue and depression (r= 0.334, P<0.001),
anxiety (r= 0.327, P<0.001), stress (r=0.329, P< 0.001), well-being (r= -0.279, P<0.001), and negative
affect (r= 0.308, P<0.001). Based on the adjusted general linear model, the education, stress and
negative affect variables were predictors of fatigue.

Conclusion:

The education, stress and negative affect predict fatigue in pregnant women, and their
identification contributes to the designation of interventions to mitigate fatigue in this group. More
studies are required to identify the causes of fatigue during pregnancy.
Integrative Medicine in the Treatment of COVID-19: An Indian Perspective
Authors: Namdeo Ajay G. , Varghese Ryan , Kapase Yogita , Kumbhar Pradnya
Published: May 2022

Background:

Over recent years, evidence-based modern medicine has overshadowed the use and efficacy of natural and traditional medicines. However, in the wake of the pandemic, the interest in the quest for therapeutic resources linked to traditional, complementary, and integrative medicine has substantially increased. This has further facilitated the research and development of potential therapeutic crude drugs or their formulations in the management of COVID-19 and the symptoms associated with the latter. This article attempts to provide a comprehensive review of the various traditional medicines used as integrative medicines in alleviating symptoms attributed to the COVID-19 infection.

Methods:

The literature was thoroughly browsed for recent research articles, systematic reviews, case studies, and review articles on ScienceDirect, PubMed, and Google Scholar using keywords like complementary medicine, alternative medicine, and holistic approach to enlist a few. Subsequently, they were thoroughly screened to include only recent studies and evidence. Additionally, the official guidelines published by the Government and other regulatory bodies were also sought to be included in the article.

Study Design:

The review article follows the narrative literature review method. However, the primary data was skimmed for relevance and only recent shreds of evidence, pertinent to the review were included.

Results:

The review elucidated the pharmacological activity of various treatment regimens in different systems of medicine, with available supportive clinical evidence. Additionally, it also underscored the importance of holistic health interventions, and how these traditional and integrative systems of medicine cater to the same.

Conclusions:

The recent evidence presents a broad-spectrum effect of these therapeutic interventions, primarily in the fields of mental health, mild to moderate, and even severe forms of the infection, employing various pharmacological pathways. These studies primarily include studies and statistics pertaining to the SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) but may include supporting evidence from other respiratory viruses. This information may prove imperative in guiding new research, and also to design and support an integrative treatment regimen. Conclusively, any suspicion pertaining to the COVID-19 infection should be sought by following the protocols recommended by the concerned health authorities of the respective region/country.
Therapeutic Evaluation of Safoof-e-Pattharphori with Sharbat BazooriMoatadil in Patients of Renal Stone
Authors: Rehman Fazlur , Ansari Mohammad Shakeel , Nizam Rabia , Hamiduddin Hamiduddin
Published: May 2022

Background and Objective:

Stone formation is one of the common urological disorders;the Unani system of medicine provides an immense treasure of single and compound formulations for the safe management of urolithiasis. The objective of the study is to evaluate the effect of Unani Medicine formulation Safoof-e-Pattharphori with Sharbat Bazoori Moatadil in patients of Hasat-ul-Kulya (Renal stone) as conservative treatment.

Method:

This was a single-arm; open-labeled, pre and post without control clinical trial entailing 30 diagnosed cases of Hasat-ul-Kulya (Renal Stone)up to 10mm diagnosed by USG, belonging to 18-65 years of age, either sex and who had agreed to sign the informed consent form and follow up the protocol. The patients were exposed with Unani formulation i.e., 5gm of Safoof-e-Pattharphori orally once daily with 50ml of Sharbat Bazoori Moatadil up to 45 days with three follow-ups. The assessments of subjective parameters were done at every 15th day of follow-up by using an arbitrary scale. The assessments of objective parameters were carried out before and after the trial. The results were analyzed statistically using Wilcoxon signed-rank test, Student’s paired t-test (two-tailed), and proportion test.

Results:

The subjective parameters like pain in the abdomen showed significant relief with (p < 0.001). Objective parameters like USG abdomen showed significant results (p <0.001). The size of the stone showed a statistically significant reduction (p <0.001). No significant adverse changes were observed in safety parameters during and after the trial.

Conclusion:

It can be concluded that the Unani formulation Safoof-e-Pattharphori with Sharbat bazoori moatadil is safe and effective in renal stone treatment.
Clinical Trials Registry of India
Aqueous solubility of high concentrated caffeine using hydrotrope and the application to the anti-cellulite cosmetics
Authors:   Department of Senior Healthcare Majoring in Cosmetic Formulation and Pharmacology, Eulji University, Seongnam, South Korea, et al. Park
Published: May 2022

This study presents measurements of the aqueous solubility of caffeine at a temperature ranging from 5 to 40°C. And the low water solubility of caffeine was increased by using a hydrotropic solubilization system. Solubility was measured with a single hydrotropic system of niacinamide or betaine and a mixed hydrotropic system of niacinamide and betaine. As a result, it was possible to prepare a high-concentration aqueous caffeine solution of about 4% at 5.9°C and about 25% at 39.9°C. The modified Apelblat equation was applied to predict the temperature dependence of caffeine solubility in aqueous solutions containing niacinamide, and our experimental data showed good agreement with the correlated values. We propose the results of this study as basic data for the development of anti-cellulite cosmetics.
Harnessing the Electronic Health Care Record to Optimize Patient Safety in Primary Care: Framework for Evaluating e–Safety-Netting Tools
Authors: Black Georgia Bell , Bhuiya Afsana , Friedemann Smith Claire , Hirst Yasemin , Nicholson Brian David
Published: May 2022

The management of diagnostic uncertainty is part of every primary care physician’s role. e–Safety-netting tools help health care professionals to manage diagnostic uncertainty. Using software in addition to verbal or paper based safety-netting methods could make diagnostic delays and errors less likely. There are an increasing number of software products that have been identified as e–safety-netting tools, particularly since the start of the COVID-19 pandemic. e–Safety-netting tools can have a variety of functions, such as sending clinician alerts, facilitating administrative tasking, providing decision support, and sending reminder text messages to patients. However, these tools have not been evaluated by using robust research designs for patient safety interventions. We present an emergent framework of criteria for effective e–safety-netting tools that can be used to support the development of software. The framework is based on validated frameworks for electronic health record development and patient safety. There are currently no tools available that meet all of the criteria in the framework. We hope that the framework will stimulate clinical and public conversations about e–safety-netting tools. In the future, a validated framework would drive audits and improvements. We outline key areas for future research both in primary care and within integrated care systems.
Domain-Specific Common Data Elements for Rare Disease Registration: Conceptual Approach of a European Joint Initiative Toward Semantic Interoperability in Rare Disease Research (Preprint)
Authors: Abaza Haitham , Kadioglu Dennis , Martin Simona , Papadopoulou Andri , dos Santos Vieira Bruna , Schaefer Franz , Storf Holger
Published: May 2022

BACKGROUND

With hundreds of registries across Europe, rare diseases (RDs) suffer from fragmented knowledge, expertise, and research. A joint initiative of the European Commission Joint Research Center and its European Platform on Rare Disease Registration (EU RD Platform), the European Reference Networks (ERNs), and the European Joint Programme on Rare Diseases (EJP RD) was launched in 2020. The purpose was to extend the set of common data elements (CDEs) for RD registration by defining domain-specific CDEs (DCDEs).

OBJECTIVE

This study aims to introduce and assess the feasibility of the concept of a joint initiative that unites the efforts of the European Platform on Rare Disease Registration Platform, ERNs, and European Joint Programme on Rare Diseases toward extending RD CDEs, aiming to improve the semantic interoperability of RD registries and enhance the quality of RD research.

METHODS

A joint conference was conducted in December 2020. All 24 ERNs were invited. Before the conference, a survey was communicated to all ERNs, proposing 18 medical domains and requesting them to identify highly relevant choices. After the conference, a 3-phase plan for defining and modeling DCDEs was drafted. Expected outcomes included harmonized lists of DCDEs.

RESULTS

All ERNs attended the conference. The survey results indicated that genetic, congenital, pediatric, and cancer were the most overlapping domains. Accordingly, the proposed list was reorganized into 10 domain groups and recommunicated to all ERNs, aiming at a smaller number of domains.

CONCLUSIONS

The approach described for defining DCDEs appears to be feasible. However, it remains dynamic and should be repeated regularly based on arising research needs.
Liposome as carrier therapy for Alzheimer’s disease
Authors: Anggraeni Andi Sri Dewi , Arsita Emilia Vivi , Suwarman Adika , Mustofa
Published: May 2022

Alzheimer's disease (AD) is the most common type of dementia. Approximately 50 million people suffer from Alzheimer's and it is expected to increase more than 100 million by 2050. According to the Diagnostic and Statistical Manual of Mental Disorders V (DSM-V), the diagnosis of AD has an onset of memory impairment and cognitive decline. Effective treatment of AD is a major challenge in the field of pharmacy and science due to the restriction from blood brain barrier (BBB). This causes poor access to pills or oral administration. Liposome as a part of nanoparticle showed to be a potential AD treatment because of its biocompatibility, flexibility, and capability to carry various therapeutic molecules across the BBB and into brain cells. Several types of liposomes provide varied therapy effect. Some factors which determine liposomes effectiveness are its structure, mechanism of action; formed; and delivery, and its preparation method. This article reviewed liposomes characteristics which has potency as carrier therapy for AD.
An impact evaluation of an education bundle for patients at risk of developing venous thromboembolism
Authors: Boyer Nicole , Skinner Robert , Breck Andrew
Published: May 2022

Aim:
Among hospitalized patients, venous thromboembolism (VTE) is a preventable cause of morbidity and mortality. This study analyzed the effects of a large-scale adoption of a prompt response and education protocol to increase VTE prophylaxis adherence in the USA.
Methods:
A Markov model was developed that simulates outcomes and costs of delivering a VTE education bundle versus not, to hospitalized at-risk patients.
Results:
The education bundle could avert more than 134,000 VTEs, 552,000 hospital days and 19,000 deaths over 5 years. Patients could save 13 million hours in work absenteeism and travel time, valued at US$237 million. Total societal savings could amount to US$2.8 billion. In scenario analyses with assumed lower-effectiveness estimates, the bundle averts 16,000 VTEs, 67,000 hospital days and 2000 deaths.
Conclusion:
A nationwide rollout of an education bundle to reduce missed doses of prescribed prophylaxis could improve quality of care, resulting in a decline in VTEs and mortality.
Editorial. Los Medicamentos Genéricos
Authors: Morla Elbi
Published: May 2022

No necesita de un resumen.
Niveles tensionales en niños y adolescentes con esteatosis hepática
Authors: Matos Imbert Ángela , Domínguez Norys Angelina , Rochits Cueto Haydee , Acevedo Rodríguez Noemí , Fernandez Genao Alina , Ortiz Hernández Rosa , Ortiz Hernández Isi Y. , Jiménez Azcona Michelle M.
Published: May 2022

Introducción: la enfermedad hepática no alcohólica (EHNA) constituye un desorden multifactorial cuyos elementos de riesgo se pueden aludir a la obesidad, el sedentarismo y el componente genético.

Objetivo: evaluar los niveles tensionales en niños y adolescentes con esteatosis hepática por sonografía de 5-18 años en el Hospital Regional Universitario Dr. Arturo Gullón.

Métodos y técnicas: se realizó un estudio descriptivo de corte transversal y fuente primaria. La muestra estuvo compuesta por de 106 participantes. Se realizó sonografía abdominal para determinar la presencia de esteatosis hepática y se midió la presión arterial sistólica y diastólica, IMC, talla y pruebas de laboratorio. Para el análisis estadístico se empleó chi-cuadrado.

Resultados: el sexo predominante en la tensión arterial sistólica fue el femenino con un 44.9 % en estadio prehipertensión, mientras que el masculino fue el sexo predominante en presión arterial diastólica con un 49.1 %. Se evidenció que los individuos con IMC del percentil 90 se encontraban en estadio prehipertensión en el percentil. El perfil lipídico (colesterol, HDL, LDL, triglicéridos) y las transaminasas (SGOT y SGPT) mostraron relación con niveles tensionales elevados con predominio en la TAD. Los valores elevados de glicemia presentan relación con las cifras aumentadas de la tensión arterial sistólica.

Conclusión: el estudio mostró que existe una relación entre la esteatosis hepática no alcohólica y el riesgo de desarrollar hipertensión arterial. Presentando relación estadísticamente significativa entre los niveles tensionales elevados y el perfil bioquímico estudiado, así como al IMC de los pacientes evaluados en la investigación.
Escala de Iniciativa de Crecimiento Personal-II: validación de la traducción al español en Paraguay
Authors: Vuyk Maria Alexandra , Codas Gerónimo
Published: May 2022

La iniciativa de crecimiento personal es un constructo que se ha investigado en los últimos años y ha demostrado un carácter transcultural. En la actualidad, se vincula al mismo con otros conceptos relacionados a la psicología clínica y el counseling. Para poder realizar estudios en los contextos latinoamericanos, resulta imprescindible que se traduzca y adapte instrumentos que midan dicho constructo. En el presente trabajo se describe la traducción al español y validación factorial de la Escala de Iniciativa de Crecimiento Personal-II en una muestra de 219 universitarios de la ciudad de Asunción (Paraguay). Además, se presentan evidencias de validez basadas en relaciones con otras variables, como ser esperanza y satisfacción con la vida. Se realizaron análisis factoriales confirmatorios y un modelado exploratorio de ecuaciones estructurales que demostraron ajuste aceptable de un modelo de cuatro factores con modificaciones, tal como proponen otros antecedentes. Por otro lado, los coeficientes de correlación de este constructo con la esperanza y satisfacción con la vida otorgan buena evidencia de validez basada en relaciones con otras variables. Se comenta la utilidad de la escala para su uso en el ámbito clínico. En particular, se apuntala su utilidad como predictor de cambio en psicoterapia, ya que el concepto se relaciona íntimamente con factores motivacionales en el proceso terapéutico, y puede ser un predictor de recaídas a largo plazo.
THE DEVELOPMENT OF EDUCATIONAL AND METHODOLOGICAL COMPLEX IN THE DISCIPLINE «EVIDENCE-BASED AND PERSONALIZED MEDICINE. EVIDENCE BASE FOR DIAGNOSING AND TREATMENT OF СOVID-19» (IN THE ENGLISH LANGUAGE) FOR THE STUDENTS OF THE MEDICAL UNIVERSITY
Authors:   Vitebsk State Order of Peoples' Friendship Medical University, Haliuchenka V.A. , Zhyltsou I.V. ,   Vitebsk State Order of Peoples' Friendship Medical University, Skreblo Y.I. ,   Vitebsk State Order of Peoples' Friendship Medical University, Adamenko G.P. ,   Vitebsk State Order of Peoples' Friendship Medical University, Kaliadka Y.I. ,   Vitebsk State Order of Peoples' Friendship Medical University
Published: May 2022

The aim of this article is to assess the possibilities of improving the quality of teaching a clinical discipline in English by developing an educational and methodological complex (EMC) for the 6th-year students of the Overseas Students Training Faculty in the discipline «Evidence-Based and Personalized Medicine. Evidence base for diagnosing and treatment of COVID-19». The theoretical and practical aspects of the teaching materials development for the methodological support of the educational process in English are discussesed in this article. «Evidence-Based and Personalized Medicine» is a new discipline taught at the university. The authors of the article have presented their original experience in creating a system of scientific and methodological support, taking into account the lack of a standardized approach to the development of teaching materials for the clinical discipline in English. The relevance of studying the issues of evidence-based and personalized medicine, including those related to the diagnosis, treatment and prevention of a new coronavirus infection, is determined by the modern needs of the healthcare system and medical education. The article defines the place of the discipline in the system of clinical disciplines taught in English, presents the main structural components and content of EMC. The authors have proposed to apply problem-based learning technology elements using the case-study method while conducting practical classes (including on-line ones), and they have also determined the role of MCQ in the knowledge control system.
ISSUE OF THEORETICAL RESEARCH AND PRACTICAL APPLICATION OF THE CONCEPT OF NATIONAL BRANDING IN THE RUSSIAN FEDERATION
Authors:   St. Petersburg State University, Soloveva-Balayan D.I.
Published: May 2022

Simon Anholt’s concept of national branding in modern Russia is analyzed. The main attention is focused on reflecting the significant methodological problems that impede the theoretical development of the concept. Difficulties of forming a strategy for the national brand of Russia, which would make it possible to create the positive image of our country more stable.
LEGAL INFLUENCE ON THE PREVENTIVE LEGAL RELATIONS IN CRIMINAL LAW
Authors:   Russian Presidential Academy of National Economy and Public Administration, Shcherbakova E.K.
Published: May 2022

The nature and limits of the legal influence on the legal relations in criminal law are studied. Legal influence on the preventive criminal law relations is based on the certain legal tools and methods that form a mechanism of preventive criminal law influence. This mechanism conceptual model contributes to problem-solving in the sphere of general and individual crime prevention.
CENSUS AS A FORM OF FIXING TERRITORIAL IDENTITY IN THE ASSESSMENTS OF YOUNG PEOPLE
Authors:   Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences, Mokin K.S. , Baryshnaya N.A. ,   Russian Presidential Academy of National Economy and Public Administration
Published: May 2022

Based on empirical research, the current hierarchy of identities among young people in the context of the All-Russian census is assessed. The role of the state in the formation of state-territorial identity, mechanisms and forms of its reproduction are evaluated.
THEORETICAL MODELS FOR POLITICAL DISSENT
Authors:   Saratov State Academy of Law, Suslov I.V.
Published: May 2022

Available theoretical approaches to the study of dissent as a political phenomenon of the communicative space are analyzed, and the conclusion about the relevance of their application in conditions of modern Russia is drawn. The research focuses on the analysis of communicative and discursive approaches, as well as the critical (neo-Marxist) paradigm.
RISKS OF PARADIGM TURNS IN THE RESEARCH OF MODERN ORGANIZATIONS
Authors:   Russian Presidential Academy of National Economy and Public Administration, Khorolceva E.B. , Fedorova A.V. ,   Russian Presidential Academy of National Economy and Public Administration
Published: May 2022

The risks associated with paradigm turns in the research of modern organizations are analyzed. Three basic paradigm turns are distinguished: from the classical paradigm to the non-classical one, from the non-classical to the post-non-classical one, and from the post-non-classical to the media one. It is proved that risks correlate with the complexity of modern organizations and the diversity of paradigms that define the ‘optics’ of the researcher.
I am charging my battery, now I am full of Energy. I am the Robot
Authors: Hansen Jan Erik , Madsen Heidi Holst
Published: May 2022

Erfaringer med chatbot-teknologi. Det Kgl. Biblioteks centrale kontaktservice ”Spørg biblioteket” har det seneste år været suppleret med en virtuel assistent.
Open Science og markedsføring in-a-box
Authors: Refn Annette , Skov Jensen Thomas
Published: May 2022

Et nyt værktøj om Open Science til forskerne.
Chronobiological disorders and their impact on gestational diabetes mellitus outcomes: the Chrono-Nutrition Gestational Diabetes Study
Authors: Messika Amalia , Toledano Yoel , Hadar Eran , Tauman Riva , Froy Oren , Shamir Raanan
Published: May 2022

Objective Studies have shown that chronobiological factors may adversely
affect glycemic control in patients with type 2 diabetes mellitus
(T2DM). Our objective was to assess the association of chronobiological
disorders with glycemic control and neonatal birthweight in women with
GDM. Design A prospective observational study was conducted. Setting
Israel Population 208 women aged 18-45 years with a singleton pregnancy
who were randomly selected from among women undergoing follow-up for GDM
at the Maternal-Fetal Medicine Unit of a tertiary medical center in 2016
and 2017. Methods Nutrition, sleep, and lifestyle patterns were assessed
from onset of GDM until birth along with glycemic control and
obstetrical outcomes. Data were collected by structured interview and
from the medical files. Main outcome measures Maternal glycemic control
and large for gestational age (LGA) neonate. Results Multivariate
analyses on a cohort of 208 women revealed suboptimal glycemic control
which was associated with a late breakfast (RR=2.26; 95% CI 1.09-4.67).
Any 10-g increase in carbohydrate intake in the evening increased the
risk 1.19 times for suboptimal glycemic control (RR=1.19; 95% CI
1.003-1.42), and 2.14 times for poor sleep quality (RR=2.14; 95% CI
1.04-4.41). The adjusted relative risk for birthweight above the 85th
percentile was associated with excessive of 10-g increase of
carbohydrate intake in the morning (RR=1.70; 95%CI 1.30-2.23) and in
the evening (RR=1.39; 95% CI 1.16-1.67). Conclusions Chronobiological
disorders are associated with suboptimal glycemic control and
large-for-gestational-age newborn in women with GDM.
Systemic Bevacizumab for Severe Recurrent Respiratory Papillomatosis
Authors: Tatineni Swetha , Warren Zachary , Applebaum Mark , Baroody Fuad
Published: May 2022

Recurrent respiratory papillomatosis (RRP) is the most common benign
pediatric laryngeal neoplasm. Various adjuvant medical therapies have
failed to reliably decrease surgical frequency in this challenging
airway disease. Recently, systemic bevacizumab has shown promise in
advanced, treatment-resistant papillomatosis. We describe the use of
systemic bevacizumab in two children with severe RRP unresponsive to
other therapies. Voice and breathing improved dramatically in both
patients with minimal side effects. Both patients have not required
surgery in 23 months and 15 months, respectively. Systemic bevacizumab
is a promising long-term treatment for severe RRP, with oncology playing
an important role in patient care.
Intestinal obstruction revealing a rare case of a supravesical internal hernia
Authors: yahia dorra bel haj , zaiem asma , yakoubi chaima , mahmoud ahmed ben , Maghrebi Houcine , kacem jameleddine montasser , heni azza el , rebai wael
Published: May 2022

A supravesical hernia (SH) is a rare abdominal wall hernia that develops
at the supravesical fossa. Their clinical manifestation is often an
intestinal obstruction. Their diagnosis is difficult but computed
tomography (CT) appearance and familiarity with the anatomy of the
supravesical fossa may allow the preoperative diagnosis.
Rehabilitation Program in Otolaryngology Unity
Authors: Moreira José , Soares Patricia , Gomes Sandra , Nunes Baltazar
Published: May 2022

Background: Head and neck cancer (HNC) have a considerable mortality and
morbidity rate. Surgery is one of the most effective treatments, however
it may compromise the independence of patients after its performance.
The Rehabilitation Nurse (RN) intervention is essential for recovery.
Objective: To compare the dependence degree between patients who
underwent RN intervention versus general health care after HNC surgery.
Methods: Patients submitted to different types of HNC surgery, were
divided into two groups intervention by the RN versus general health
care, the outcome was the Barthel Index Discharge categorized as
dichotomic to assess the patient independence at discharge and their
differences calculated by statistical analysis. To analyze the effect of
the RN intervention on dependence, a Poisson regression model was used,
adjusting the confounding factors Initial Barthel Index and Age in the
variable Barthel Index Discharge>91. Results: In
middle/late postoperative period, in the group with RN intervention
(n=79) the hospitalization time was reduced by 4.29 days versus general
health care (n=72). At discharge, the Barthel Index (p<0.005)
improved significantly in the RN intervention group compared to the
general health care group. The intervention of the RN after surgery had
a positive effect on the functional capacity of the patients, after
adjusting the confounding factors (RR:1.47; 95%CI[1.02; 2.12]).
Conclusion: The RN intervention is an added value in the independence of
the patient submitted to HNC surgery. It is an innovative study in
patient after diagnosis HNC, showing that intervention of RN through
rehabilitation programs allows independence after his surgery. 5
succinct Key points: Independence of the patient submitted to HNC
surgery; early rehabilitation in postoperative period; rehabilitation
nursing programs; self-care optimization; regression model.
Synthesis and biological activity of alkylthio and arylthio derivatives of tert-butylquinone
Authors: Djordjevic Jelena , Kolarevic Stoimir , Jovanovic-Maric Jovana , Oaldje-Pavlovic Mariana , Sladic Dusan , Novakovic Irena , Vukovic-Gacic Branka
Published: May 2022

Biological activity of 2-tert-butyl-1,4-benzoquinone (TBQ) and its derivatives, 2-tert-butyl-5-(2-propylthio)-1,4-benzoquinone, 2-tert-butyl-5- -(propylthio)-1,4-benzoquinone, 2-tert-butyl-5,6-(ethylenedithio)-1,4-benzoquinone, 2-tert-butyl-5-(phenylthio)-1,4-benzoquinone and 2-tert-butyl-6-(phenylthio)- 1,4-benzoquinone, were tested for their antioxidant, antibacterial, toxic, cytotoxic and genotoxic potential. Using the DPPH test, all derivatives showed good antioxidant activity, better than ascorbic acid, and the 2-tert- -butyl-5-(propylthio)-1,4-benzoquinone derivative showed the strongest effect. Better antibacterial potential was observed against Gram-positive bacteria in the broth microdilution method in which the 2-tert-butyl-5-(phenylthio)-1,4- -benzoquinone derivative showed the strongest activity (MIC = 15.6 ?M). The results of toxicity tests, using the Brine shrimp test, indicated that the derivatives lose their toxic potential compared to TBQ, except for 2-tert-butyl-6- -(phenylthio)-1,4-benzoquinone, which showed a 3 times stronger effect. Cytotoxicity was assessed by the MTT assay in 24 and 72 h treatments in MRC-5, HS 294T and A549 cell lines in threefold decreasing gradient (11, 33 and 100 ?M). Modifications potentiate the cytotoxic effect, and the strongest effect was observed with the 2-tert-butyl-5,6-(ethylendithio)-1,4-benzoquinone derivative. In addition, the genotoxic potential was examined in the MRC-5 cell line using the comet assay. All tested derivatives of TBQ showed a genotoxic effect at all applied subtoxic concentrations. In general, the chemical modifications of TBQ enhanced its biological activity.
A Young Girl's Recollections of Edgar Allan Poe
Authors: SEMTNER CHRISTOPHER P.
Published: May 2022

In a previously unpublished essay, Elma Mary Gove Letchworth (1832–1921) details her visits to the Fordham, New York, cottage of American poet, critic, and short story writer Edgar Allan Poe (1809–49). Her account provides a young girl's impressions of the famous author and insights into Poe's domestic life, humor, and fondness for children. The present paper examines Letchworth's essay and compares it with the reminiscences of other acquaintances of Poe, including a similar article written by her mother, Mary Gove Nichols (1810–84), in order to evaluate the accuracy of Letchworth's account.
“An Idyl of a Berry Pasture”: A Rediscovered Mary Wilkins Freeman Story
Authors: AYDELOTT KATHRINE C. , Wilkins Mary E.
Published: May 2022

In 1889, Mary E. Wilkins Freeman published a short story called “An Idyl of a Berry Pasture” in Once a Week, an early imprint of Collier's Weekly. Since that time, the story has been lost. Rediscovered, the tale depicts a meeting between the impoverished Viola Bell and the upstanding Elisha Burney and Viola's unsuccessful attempt to win his heart. Besides realistic dialect, careful descriptions of nature and village life, and pointed observations about the domestic lives and attitudes of New England men and women, Freeman revisits themes of poverty and class distinctions, and the polarities of freedom and safety, masculinity and femininity, authenticity and conformity, and individual and community. Published at a time when Freeman had established herself as a writer of the New England soil, and containing hallmarks of her best work, “An Idyl of a Berry Pasture” deserves placement among Freeman's strong and evocative New England stories.
Muriel Rukeyser's Christmas Message for Teachers: The History and Text of “Christmas and the Image of the Teacher”
Authors: ROESSEL DAVID , POMAR JAMES , Rukeyser Muriel
Published: May 2022

In 1959, the poet Muriel Rukeyser was asked to write the Christmas issue of the Teacher's Letter, a trade newsletter for educators from Croft Educational Services. The text that was published was not Rukeyser's, and her anger and discomfort at what she called a “grotesque” of her essay is clear from her correspondence with the editor. Rukeyser's essay, “Christmas and the Image of the Teacher,” which appears here, is held in the Muriel Rukeyser Papers in the Manuscript Division of the Library of Congress. The introduction discusses the aesthetic and political reasons why Croft did not accept Rukeyser's piece as it was submitted.
Robert Frost, Man of Letters
Authors: SANDERS DAVID
Published: May 2022

This volume of Frost's collected letters, the first of four volumes to be issued by Harvard University Press, makes an auspicious start on an important literary project. The letters themselves—whether persuasive, appreciative, or explorative in intent—are arresting in their clarity and immediacy, their humor and tact, everywhere revealing a craftsman of language in service of an original mind and complex personality. While creating an epistolary autobiography in their self-revelation, they provide a fascinating window into the poetry and literary history of the early twentieth century. The volume is superbly edited. Its introductions and notes, indexes and appendixes are thorough without being cumbersome, offering a rewarding experience to anyone with a serious interest in Frost and an invaluable resource for scholars. The next three volumes, if done as well, as we have every reason to expect, will complete a fitting tribute to one of our greatest and most unusual poets.
“Such a Great Light”: Letters to Louisa and Abba Alcott from the Holley School for Freed People and the Story of Winnie Beale's Emancipation
Authors: SHELDEN MARY LAMB , Holley Sallie , Putnam C. L.
Published: May 2022

This article transcribes and offers historical introduction to a hitherto-unpublished collection of letters from Sallie Holley and Caroline Putnam, founders of the Holley School for the freed people of Lottsburgh on Virginia's Northern Neck, to renowned author Louisa May Alcott and her mother, Abigail May Alcott, who over many years solicited and sent contributions to the school. As good ambassadors for their project, Holley and Putnam sent letters of gratitude documenting the use of various donated items and offering a vivid picture of the daily life of the school. The letters also contain three versions of a transcribed slave narrative of one of the school's neighbors, Winnie Beale, who was sold South before the Civil War and worked her way back to Lottsburgh after emancipation.