bluuebunny/crossref_metadata_2025 huggingface dataset:
CRISPR/Cas9-Enhanced CAR-T Cell Therapy for Hematological Malignancies
Authors: Li Zewan
Published: January 2025

CRISPR/Cas9 technology has brought revolution to the field of gene editing, offering precise and efficient tools for genetic modifications. One of its most promising applications lies in improving CAR-T cell therapy for treating hematological malignancies. Among approaches to treating blood cancers, CAR-T therapy, which programs T cells to recognize and eliminate cancer cells, has shown some success for B-cell malignancies such as diffuse large B-cell lymphoma (DLBCL) and B-cell acute lymphoblastic leukemia (ALL). However, challenges such as immune evasion, cytokine release syndrome (CRS), neurotoxicity, and limited CAR-T persistence remain significant barriers. CRISPR/Cas9 can optimize CAR-T therapy by precisely inserting CAR genes into specific loci, knocking out inhibitory genes like PD-1 to enhance persistence, and enabling multi-targeting strategies to overcome tumor immune escape. Clinical trials demonstrate the feasibility and potential of CRISPR-edited CAR-T cells, showing improved safety, durability, and efficacy. This study explores the synergistic application of CRISPR/Cas9 in CAR-T therapy, addressing its current limitations and providing a pathway to safer and more effective treatments for hematological malignancies
The Role of nsp5 in SARS-CoV-2
Authors: Lu Xingyu
Published: January 2025

SARS-CoV-2, the causative agent of the COVID-19 pandemic, is a single-stranded positive-sense RNA virus belonging to the coronavirus family. It emerged at the end of 2019 and has swiftly disseminated globally, presenting an unparalleled threat to public health worldwide. The non-structural protein 5 (nsp5) is a key component in the SARS-CoV-2 replication process, also known as the main protease (Mpro or 3CLpro), which is essential for cleaving viral polyproteins into functional proteins required for replication and transcription. The conserved characteristics and essential role of nsp5 render it an attractive target for antiviral pharmacological development. Recent developments in nsp5-targeted treatments, like Paxlovid, exhibit significant effectiveness in decreasing COVID-19-associated hospitalizations and fatalities. However, the development of nsp5 inhibitors continues to face challenges due to viral mutations and specific administration requirements. This review explores the structural and biochemical properties of nsp5, with particular attention to its catalytic dyad, substrate recognition sites, and three-domain architecture that underpin its role in viral replication. It highlights the potential impact of nsp5 research on advancing antiviral strategies, aiding in the fight against current SARS-CoV-2 infections, and laying the groundwork for future coronavirus outbreak preparedness.
Employee Performance and Differentiation Management
Authors: Su Jinyao
Published: January 2025

In the past, people's management of employee performance was mainly in the company's management structure. At the same time, in this process, in order to achieve the overall efficiency and income of the enterprise, and promote better economic development, people pursue more freedom in life and efficiency in work. The relationship between employee performance and differentiated management is analyzed in this paper. This research also explores Maslow's hierarchy of needs theory and employee differentiated management mode. This paper discovers the relationship between employee performance and differentiated management through research. The study found that the two exhibit an inverted U-shaped correlation, that is, the degree of differentiated management is taken as the independent variable, and employee performance is taken as the dependent variable, and the level of employee performance is affected by the degree of employee differentiated management, which provides new ideas and research directions for further research on employee performance and differentiated management.
The Resilience of the Apparel Supply Chain During Covid-19: A Review
Authors: Fang Sichao
Published: January 2025

The supply chain plays a vital role in global trade and economic development. This paper reviews the research on the resilience of the apparel supply chain during the COVID-19 pandemic and concludes with four key findings. First, prior to the pandemic, the supply chain operated within a complex global framework characterized by clear regional specialization, but it revealed vulnerabilities due to over-reliance on specific regions, lack of transparency, and inadequate inventory systems. Second, academic focus on efficiency often overlooked disaster preparedness, leaving industries ill-equipped for crises. Third, during the pandemic, the supply chain encountered significant disruptions, including factory closures, fragmented supply routes, and distribution challenges that affected production levels. Small and medium-sized enterprises (SMEs) faced heightened difficulties, while larger brands had to adapt. Fourth, resilience during this period led to transformative changes, with swifter responses and an increased reliance on strategies aimed at enhancing supply chain flexibility. Finally, future research must focus on developing predictive disruption models, integrating digital technologies for smarter supply chains, and promoting sustainable practices that align with environmental and ethical standards. By fostering these initiatives, a more resilient and sustainable apparel supply chain can be established, better equipping the industry to face future uncertainties while achieving economic, environmental, and social benefits.
Research on the Application of PID Control Algorithm and Fuzzy Control Theory in the Field of Temperature Control
Authors: Zhang Shixian
Published: January 2025

In the field of industrial automation control systems, PID control algorithms are widely used in various control fields such as temperature, speed and position. Among them, fuzzy PID control can improve control accuracy and stability, can significantly improve product quality and production efficiency, in food processing, chemical engineering, pharmaceutical and textile industries have a wide range of applications. Therefore, this paper comprehensively discusses the theory of fuzzy PID control algorithm and its application in the field of temperature control. The advantages of fuzzy PID control in complex industrial environments are emphasized through a comparative analysis with other temperature control methods as well as traditional linear PID control. The research indicates that by optimizing the control algorithm and hardware design, the fuzzy PID control algorithm can reduce the system overshoot and steady state error, thus improving the control accuracy and response speed. At the same time, the introduction of multivariable PID controllers or the use of advanced multivariable control strategies can achieve coordinated control of multiple variables, thereby improving the performance of the entire system. In addition, the integration of advanced energy management system and data analysis technology can comprehensively monitor and optimize the management of energy consumption, further improving the energy efficiency of the system
The Application Potential of Microelectronic Processing and Integrated Circuit in Mechanical Design
Authors: Zheng Hanbing
Published: January 2025

The rapid development of microelectronic processing has not only fostered its interdisciplinary fusion with mechanical design. With the introduction of microelectronic processing, the precise control capabilities of mechanical systems have been significantly bolstered, and the energy consumption of machinery and equipment was also optimized, which has led to an increasingly high degree of automation, allowing for the execution of complex tasks and autonomous decision-making. Additionally, as both technologies continue to evolve towards smaller scales, their application scope is expanding, including Micro Electro Mechanical System (MEMS), sensors, etc. This paper explores the application of microelectronic processing and integrated circuits in mechanical design, elucidating how advancements in microelectronics enhance the automation and intelligence of mechanical equipment. Furthermore, with the rise of nanotechnology, the paper discusses new applications of microelectronic processing in mechanical design fields such as automation control systems, sensors, and embedded systems. Meanwhile, the cost reduction and standardization of integrated circuits have boosted their popularity in a wider range of fields
New power system analysis and external disaster prevention challenges and prospects
Authors: Liu Hongfeng
Published: January 2025

Constructing a new power system is fundamental to achieving the carbon peak and carbon neutrality targets. However, this evolving system is highly susceptible to external disasters, presenting challenges to its operational stability. An increasing number of transmission lines are passing over mountains as China's power grid gradually grows larger. These mountains are prone to large-scale wildfires, ice storms, and lightning strikes, which poses a severe danger to the to the safety and reliability of the power system. This paper examines the impact of three representative external threats to the new power system: wildfires, ice accretion, and lightning strikes. It delves into topics such as wildfire alert systems, the icing of ultra-high voltage(UHV) ground wires, and the prevention and control of lightning strikes in distribution networks. It also discusses the respective disaster mitigation strategies and anticipates the future evolutionary trajectory of the new power system, thereby offering insights and research directions for countering external disasters within the new power infrastructure
Anchoring of Radially Expandable Microcapsule Robots in Blood Vessels Based on the Anchoring Method in Fan-Shaped Peristaltic Tubes
Authors: Zhang Yuduo
Published: January 2025

Radially expandable capsule robots are essential in alleviating thrombosis due to their unique anchoring and expansion capabilities within blood vessels. Despite their potential, research in this area remains limited, highlighting the need for further exploration. This study draws inspiration from the stable anchoring mechanisms observed in fan-shaped peristaltic tubes to establish a robust anchoring resistance model specifically for capsule robots in vascular environments. The research investigates the biomechanical characteristics of blood vessels under expansion conditions, deriving the longitudinal profile equation to better understand these interactions. Based on the established model, various optimization methods are proposed to enhance the anchoring performance of the capsule robots. To validate the model's accuracy, anchoring resistance is tested using a phantom vessel on an experimental platform. By integrating kinematic and mechanical analyses, an inchworm-type expansion force model is developed to evaluate anchoring performance quantitatively, allowing for an in-depth analysis of how design parameters influence anchoring resistance. This provides vital theoretical support for the design and optimization of capsule robots aimed at improving clinical outcomes in thrombotic conditions
The Application Analysis of Sequential Circuit in the Design of Multifunctional Clock
Authors: Zhou Yixuan
Published: January 2025

As time management is getting harder in this fast pace of life, traditional clocks have encountered many problems for its complexity and simple functions because it can also be a problem to integrate multiple capabilities into one device based on mechanical inner structure. Therefore, digital clocks can be a better choice and this experiment intended to provide a way of designing the circuit of a multifunctional digital clock based on components used in sequential circuits. Within the circuit, counter, reversible counter and comparator were applied to realize counting, time-setting, countdown, alarming and on-time alarm functions. In this article, the working principles of main chips and the key designing methods will be introduced. NI Multisim was applied to provide simulated results of the behavior of this clock. The results turned out to meet all expectations even though the experiment had inevitable limitations. Thus, it is suggested that further researches can be conducted to ensure a more energy-efficient and precise clock with more advanced useful capabilities.
Sowing the seeds of change through private sector partnership
Authors:   Building Inclusive Markets and Decent Work for Syrian Refugees and Lebanese Host Communities (Project),   ILO Regional Office for the Arab States,
Published: January 2025

The ILO Building Inclusive Markets and Decent Work for Syrian Refugees and Lebanese Host Communities (BOUZOUR) project, funded by the Swedish International Development Agency (Sida), is working to strengthen agricultural value chains, particularly in the cherry sector, to create decent jobs and improve livelihoods. The BOUZOUR project employs the ILO’s Approach to Inclusive Market Systems (AIMS) to safeguard jobs and livelihoods of vulnerable Lebanese and Syrian communities affected by the crises in Lebanon, and to encourage decent job creation for both groups in sectors with potential. One of the key value chains the BOUZOUR project targets is the cherry sector, which has untapped potential for export growth and season extension. With the right support, Lebanese farmers can access new markets, increase their revenues, and boost job creation. Through the project’s pilot scheme, ILO is working with private sector actors like Nasr Rahme, an agricultural company, to bridge the gap between farmers and international markets. The project provides technical guidance, cost-sharing for investments, and ensures that farmers receive training, inputs, and access to new market opportunities.
Influencers’ Impact on Consumer Engagement and Sales Conversion on Social Media: Facebook vs Instagram
Authors: Hasan Mahamudul , Sifat Annur Islam
Published: January 2025

The impact of social media influencers on consumer engagement and sales conversion on Facebook and Instagram is deliberate in this study. As a quantitative research approach, it quantifies the user engagements and buying patterns, and shows a distinct variance of both the platforms. The study shows that engagement and conversion rates are higher with Instagram compared to Facebook, more so for female users. However, males use Facebook more than other social network sites, Facebook more than any other social network site.
Robust anticancer efficacy of Naja haje venom-loaded silica nanoparticles against triple-negative breast cancer xenografts in a preclinical rat model
Authors: Soliman Nabil , Shalaby Amr , Mohamed Heba , Alashqar Sara , Ammar Mohamed
Published: January 2025

Background:
Breast cancer, a prevalent disease affecting women globally, is particularly aggressive and has limited treatment options.

Aim:
Snake venom, containing active chemicals, has shown potential in medicine.

Methods:
The study investigates the anticancer effect of Egyptian cobra Naja haje venom alone and in combination with Nanoparticles on Triple-negative breast cancer (TNBC) in vivo. The study involved dividing experimental animals into five groups, each with 10 rats, each treated with different doses of crude venom, G2 and G3, respectively. The study involved loading venom onto nanoparticle-based delivery systems, measuring inflammatory cytokines and tumor markers, extracting RNA, real-time qRT-PCR gene expression, and histopathological examination of breast tissue.

Results:
The study involved administering Naja haje crude venom at higher (1/5 LD50) and lower (1/20 LD50) dose levels in groups G2 and G3, respectively.

Conclusion:
The study found that venom treatment in groups G4 and G5 significantly improved inflammatory cytokine and tumor markers levels, increased expression of tumor-suppressor genes, and increased apoptosis and necrosis.
Isolation and molecular identification of bacteria from sheep with eye infections
Authors: Hasan Mustafa , Fahad Omar , Hussein Mohammed , Owain Maher
Published: January 2025

Background:
Ocular disease in sheep is a severe concern for the health and welfare of livestock animals, as well as losses of productivity and value to the livestock industry.

Aim:
This study aimed to isolate and characterize bacteria in sheep with eye disease on the molecular level.

Methods:
One hundred fifty sheep with eye infections were treated, and tissue samples were taken for microbiological studies. We isolated bacteria from traditional cultures and discovered molecules by polymerase chain reaction (PCR) of single bacterial genes.

Results:
A total of 150 ocular samples were collected from sheep, with bacterial growth observed in 120 samples, resulting in an isolation rate of 80%. S. aureus was the most bacteria isolated in this study, which PCR also confirmed. We found antibiotic-resistant bacteria such as Staphylococcus aureus, Escherichia coli, and Pasteurella multocida. These results reveal that preventing sheep ocular infections requires the effectiveuse of antibiotics.

Conclusion:
This study suggests the prevalence of bacterial infection in sheep eyes and argues the utility of molecular methods in veterinary diagnosis. Record levels of antibiotic resistance must be maintained in animal husbandry and the use of antibiotic stewardship programs.
First case report of fibropapillomatosis tumor regression identified through photoidentification and histopathology in a Chelonia mydas in Itapirubá, Santa Catarina, Brazil
Authors: rez Yohany , Lima Samara , Souza Gustavo , o Thayana , Chenard Marina , Helayel Michel , rsico Eliane , Silva K , Alencar Nayro
Published: January 2025

Background:
Fibropapillomatosis (FP) is a tumor disease primarily affecting juvenile sea turtles, often characterized by external growths that can regress spontaneously. This study reports the first documented case of total tumor regression in a free-living green turtle (Chelonia mydas) with fibropapillomatosis in southern Brazil.

Case Description:
A juvenile green sea turtle (Chelonia mydas) was captured and recaptured on Itapirubá Beach, Santa Catarina, Brazil, showing sing of tumor regression with a period of 302 days between captures. At the first capture, photographs of the head and other regions were taken for photoidentification, along with documentation of fibropapilloma sites and tumor scoring. Tumor samples from the initial capture were histopathologically confirmed as fibropapillomas. At the recapture, the turtle showed a slight increase in carapace length, remaining classified as a juvenile. Tumors observed during the first capture were absent at recapture, with only scars remaining in the affected areas. Photoidentification confirmed the recapture, facilitating case monitoring. Tumor regression in this turtle is likely linked to various environmental and ecological factors.

Conclusion:
Spontaneous regression of fibropapillomatosis (FP) tumors remains a crucial indicator in the health monitoring of sea turtle populations. This is the first documented case of FP regression in this region of Brazil, suggesting that the turtle's increasing age and reduced exposure to anthropogenic pressure may have contributed to the tumor's regression. Although clinical follow-up of free-living sea turtles is challenging, reports of FP tumor regression are vital for understanding the health dynamics of sea turtle populations.
Variación altitudinal del contenido de carbono aéreo de bosques secos tropical en la Reserva Natural Laipuna al sur de Ecuador
Authors: Gonzalez Valdiviezo Karina , Eguiguren Paúl , Homeier Jürgen
Published: January 2025

Los bosques secos tropicales, son ecosistemas únicos y diversos, pese a su importancia biológica se encuentran entre los más amenazados del mundo, las presiones sociales y económicas han provocado una reducción significativa de su cobertura, lo que ha afectado su capacidad de proporcionar servicios ecosistémicos. El objetivo de este estudio fue conocer los cambios de contenido de carbono en la biomasa aérea en dos pisos altitudinales 600 y 1200 m s.n.m. en la Reserva Natural Laipuna de Naturaleza y Cultura Internacional. Se registró el diámetro a la altura del pecho (DAP) y altura total de todos los individuos arbóreos con DAP ≥ 10 cm en seis parcelas permanentes de una hectárea. Para la estimación del carbono en la biomasa aérea se usó la ecuación de Chave, considerando el DAP (cm) y la altura de los árboles (m), así como también la densidad de madera (g/cm3) de cada una de las especies presentes dentro de las parcelas. No se encontraron diferencias estadísticas entre los contenidos de carbono dentro del área evaluada estas reservas fueron entre 35,6 Mg C ha-1 y 43,2 Mg C ha-1 a 600 m s.n.m. y 1 200 m s.n.m. respectivamente, demostrando así que la altitud es un factor que no influye en el almacenamiento de carbono aéreo. Se considera que este tipo de bosque representa una opción para contrarrestar el aumento de CO2 atmosférico, siendo este un justificativo importante para su conservación, más aún cuando el bosque se encuentra bajo procesos dinámicos de crecimiento.
Estimación del coeficiente de cultivo (Kc) para el cultivo de pimiento mediante lisímetro volumétrico en zona productiva del sistema de riego Campana-Malacatos
Authors: Jaramillo Jorge , Cordero Jimmy , González Aníbal , Reinoso Marco
Published: January 2025

Este estudio se llevó a cabo en respuesta a la falta de información sobre las necesidades hídricas de los cultivos para la planificación y diseño de sistemas de riego. El objetivo principal fue determinar las necesidades hídricas del cultivo de pimiento (Capsicum annuum) para mejorar la eficiencia en el uso del agua de riego. La investigación se realizó en una parcela del barrio San José, que forma parte del Sistema de Riego Campana-Malacatos del cantón Loja. En su desarrollo se utilizó el método de Penman-Monteith modificado, implementado a través del software Cropwat, para calcular la evapotranspiración del cultivo de referencia (ETo). La evapotranspiración del cultivo de pimiento (ETc) se determinó mediante el método de lisímetro volumétrico. Además, se consideró el coeficiente de cultivo (Kc) en cada fase fenológica, tomando en cuenta la ETo y ETc. Los resultados indicaron que el requerimiento total de agua para el período vegetativo del cultivo fue de 1124,43 mm, lo que equivale a 11244,3 m3 ha-1. Se observó que los valores de Kc aumentaron hasta la fase de desarrollo del fruto y luego disminuyeron durante la fase de cosecha. Estos valores fueron 0,51, 0,69, 1,01 y 0,85 para las fases de crecimiento vegetativo, floración y fructificación, desarrollo del fruto y cosecha, respectivamente.
GAMBARAN SELF COMPASSION PADA DEWASA AWAL DI JABODETABEK
Authors: Cendana Fitriya Sri
Published: January 2025

Penelitian ini bertujuan untuk menggambarkan tingkat self-compassion pada individu dewasa awal di Jabodetabek. Self-compassion adalah kemampuan memperlakukan diri sendiri dengan kebaikan, kesadaran terhadap pengalaman manusia universal, dan keseimbangan dalam menghadapi emosi negatif. Studi ini melibatkan 422 partisipan dewasa awal berusia 20–40 tahun. Hasil penelitian menunjukkan mayoritas partisipan berada pada kategori self-compassion sedang (76,8%), dengan dimensi common humanity memiliki rata-rata skor tertinggi dibandingkan dimensi lainnya. Temuan ini mengindikasikan bahwa individu di Jabodetabek memiliki kesadaran terhadap kesamaan pengalaman manusia, meskipun masih ada ruang untuk meningkatkan dimensi self-kindness. Penelitian ini menjadi langkah awal dalam memahami self-compassion pada populasi dewasa awal di kawasan urban.
Interseccionalidade e mulheres com deficiência física: enfrentando o preconceito duplo
Authors: Santos Thais Aparecida , Carvalho-Freitas Maria Nivalda de
Published: January 2025

A inclusão contribui para a criação de um ambiente mais diverso e igualitário. Isso reflete valores de respeito, valorização das diferenças e combate à discriminação. Tendo em vista que o processo da deficiência gera sentimentos, emoções e implicações psicossociais, a presente pesquisa teve como objetivo compreender os impactos dos aspectos contextuais e culturais nas trajetórias de vida e na subjetividade de mulheres com deficiência física congênita ou adquirida na primeira infância. A investigação tem natureza qualitativa, tipo exploratório e se operacionaliza pela utilização de entrevistas semiestruturadas, analisadas pela Análise de Conteúdo. As participantes nos auxiliaram na construção de nossas categorias analíticas: i) Preconceito e interseccionalidade: narrativas da inclusão e exclusão de mulheres com deficiência; ii) Gênero e deficiência: interseções e perspectivas; iii) Acessibilidade no trabalho: (re)significações entre inserção, inclusão na busca do reconhecimento profissional; e iv) Acessibilidade escolar: construções e percalços nas vivências da deficiência. A deficiência  se insere como um fator marcante na vida dessas pessoas, levando em consideração sentimentos, emoções, angústias, sofrimentos, e em contrapartida, reconhecimento, pertencimento e (re)significações face a própria deficiência. O fator gênero, propiciou fatores capacitistas, frente ao trabalho, lazer, escola e coletividade. O trabalho foi vivenciado como um motor de pertencimento subjetivo e social.
Efficacy of liposomal amphotericin B in treating fungal meningitis in AIDS Patients: A review article
Authors:   General Medicine Practice Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia., Khan Sariya
Published: January 2025

Cryptococcal meningitis is an alarming fungal infection that usually affects the meninges surrounding the brain and spinal cord. The causative organism is Cryptococcus neoformans. Although this infection can occur in normal individuals, it is more often seen in patients with human immunodeficiency virus/acquired immunodeficiency syndrome. Amphotericin B is an antifungal medication often used to treat severe fungal infections. It belongs to the class of polyene antifungal drugs, and it acts by binding to the cell membrane of the fungus. This causes some essential cellular components to leak out and ultimately the fungus dies. However, the administration of Amphotericin B is associated with toxicity. Therefore, lipid formulations are preferred to decrease the toxicity and increase the therapeutic index of the drug. It is widely used since it has a longer tissue half-life, the drug induced toxic effects are lower and it can penetrate the brain tissue efficaciously. This review collects and analyzes several research studies and literature reviews found in the electronic databases. The inclusion criteria prioritize studies focusing on the efficacy and drawbacks of using liposomal Amphotericin B as a treatment for fungal meningitis. In conclusion, liposomal Amphotericin B showed more effective treatment compared to other available antifungal drugs. Patients treated with a single dose of liposomal Amphotericin B coupled with fluconazole and flucytosine exhibited fewer adverse events and the mortality rate was also lower as compared to the control group.
Biodiesel production using simultaneous esterification-transesterification method from waste cooking oil with CaO/Fe2O3 bifunctional catalyst
Authors: Buchori Luqman , Widayat Widayat , Anggoro Didi Dwi , Sulardjaka Sulardjaka , Aqiila Ammara , Putri Nadia Rizki Pramesti Setya
Published: January 2025

Biodiesel is one of the products resulting from the initiation of energy diversification which can overcome the energy crisis both in Indonesia and in the world. Biodiesel can reduce combustion emissions. The purpose of this study was to produce biodiesel from waste cooking oil (WCO). The study was conducted using the simultaneous esterification-transesterification method with the help of a catalyst. The catalyst used was a bifunctional catalyst, namely CaO/Fe2O3. Waste cooking oil raw materials and biodiesel products were analyzed by GC-MS, while the catalyst was analyzed by SEM-EDX and XRD. The catalyst calcination temperature was varied at 750-950°C and the esterification-transesterification reaction time was varied at 1-5 hours. The results of the study showed that the highest biodiesel yield was obtained at 82% at a catalyst calcination temperature of 800°C and a reaction time of 4 hours. The methyl ester composition formed was 97.61%. The research results show that the biodiesel products produced comply with SNI 7182-2015 standards. This finding proves that waste cooking oil can be used as a raw material for biodiesel so that it will reduce the impact of environmental pollution.
Economic stability in the GCC countries: A comparative study of the Kingdom of Bahrain and Sultanate of Oman
Authors: Babu Manju Rajan , Taqi Mohammad , Salari Emma
Published: January 2025

The present study focuses on economic stability in Gulf Cooperation Council (GCC) countries with special emphasis on the economy of Kingdom of Bahrain and Sultanate of Oman. This study is an attempt to examine Gross Domestic Product (GDP), per capita, unemployment, inflation, and interest rates in the Kingdom of Bahrain and Sultanate of Oman. The fluctuation in oil and gas prices affects the growth and development of economies the Gulf Cooperation Council to maintain stability and continuous growth. The present research investigates the major economic indicators like GDP growth, inflation rates, and unemployment rates to assess the resilience of the economies of the Kingdom of Bahrain and the Sultanate of Oman. It also examines the effects of diversification initiatives on the long-term economic stability of Bahrain and Oman, including Vision 2030 and investments in non-oil sectors. By examining both historical trends and current policy frameworks, it provides insights into the strategies that Bahrain and Oman should employ to reduce risks and enhance economic resilience in an increasingly unpredictable global economy. The results emphasize the importance of strategic planning and regional collaboration in promoting long-term economic growth and stability in the Kingdom of Bahrain and the Sultanate of Oman.
Developing Speaking Material Based on Storytelling by Using YouTube in The Tenth Grade Students of SMA Negeri 1 Bahorok Academic Year 2023/2024
Authors: Al Khairi Ilham , Risnawaty Risnawaty , Asnawi Asnawi
Published: January 2025

This study aimed to develop the leaning module in speaking based on storytelling by using YouTube in the tenth grade students of SMA Negeri 1 Bahorok academic year 2023/2024. The research was used to identify the effectiveness and the result the combination between the old techniques with the modern technology like YouTube. There were 12 students as the participants who study in SMA Negeri 1 Bahorok. The methodology used in this study was research and development by Borg and Gall that includes ten steps of the process. There were some questionnaires give to the students and expert to get the rich. In collecting the data, pre-test and post-test were used to get the distinction between the old and the new learning activity. The test measured by using N-Gain Score to obtain the effectiveness of the new design applied in the class. Moreover, the questionnaires were also given to the experts. Both of them gave the positive feedback to the use of YouTube in the speaking storytelling module. The result indicates that the students need to utilize the technology in their learning activities. By getting 59.18% in N-Gain score, it shows the effectiveness of the speaking based on storytelling technique by using YouTube. The expert also validated several aspects such: content, language, feasibility and design. Most of them were in moderate and high position measured by using Aiken’s validation. In short, the learning module can be applied in the educational program. In other case, it also can be implemented in other genres.
Bibliometric Analysis of Artificial Intelligence for Digital Literacy
Authors: Jantakun Kitsadaporn , Jantakun Thiti , Jantakoon Thada
Published: January 2025

This study presents a comprehensive bibliometric analysis of Artificial Intelligence (AI) for digital literacy research from 2015 to 2024, utilizing citation analysis on 223 articles from the Dimensions database. The research examines publication trends, author collaborations, and thematic focuses in the field. Findings reveal a significant publication growth, with a peak in 2020 followed by fluctuations in subsequent years. The analysis highlights the field’s interdisciplinary nature, with computer science and education emerging as dominant areas. Key research themes identified through co-word analysis include educational applications, technological integration, and broader societal impacts. The emergence of “AI literacy” as a significant keyword underscores the evolving nature of digital competence in the AI era. Author collaboration networks reveal established experts and researchers with strong collaborative ties, indicating a dynamic research community. The study identifies challenges and opportunities in AI for digital literacy, including ethical considerations, teacher preparation, and the potential for personalized learning. This analysis provides valuable insights into AI’s current state and future directions for digital literacy research, emphasizing the need for continued interdisciplinary collaboration and the development of inclusive AI literacy programs. The findings suggest a growing recognition of AI’s role in shaping digital literacy practices and the importance of preparing learners for an AI-integrated future.
Development of an Active Play Learning Model to Promote Executive Functions for Elementary School Students
Authors: Kongthanajindasiri Somkiat , Sungkaew Manop , Sawangsri Benchaporn
Published: January 2025

In this study, we aimed to develop an active play learning model to enhance cognitive thinking skills in elementary school students. We employed a qualitative research methodology, targeting health and physical education teachers from schools in Suphan Buri Province in Thailand. We collected data through individual surveys and in-depth interviews and performed data synthesis using documents and focus groups to guide the model’s development. The research findings revealed that teachers have a moderate understanding of cognitive thinking skills and the active play learning model. Although sports activities are regularly incorporated into lessons, they are not done so effectively enough to develop cognitive thinking skills. However, teachers recognize the importance of organizing activities to help students develop social skills through play. Therefore, we recommended additional training to enhance the active play learning model’s knowledge and understanding and ensure its effective implementation in teaching and learning. Based on data synthesis, we focused on three key areas: working memory skills, inhibitory control and reflective thinking skills, and cognitive flexibility skills. We utilized a variety of games and activities, such as rock-paper-scissors, imaginative block games, and treasure hunts using maps, to stimulate skill development in each area.
Enhancing Learning Efficiency and Critical Thinking Skills of Vocational Nursing Students: A Hybrid Instructional Approach Based on Cooperative Learning and Project-Based Learning
Authors: Xie Qiuxia , Jantharajit Nirat , Srikhao Sarit
Published: January 2025

The purpose of this study is to examine the design and implementation process of Project-Based Cooperative Learning (PBCL) teaching models. The research initially introduces the theoretical framework, encompassing cooperative learning theory, project-based learning theory, and the theory of PBCL. Subsequent sections elaborate on the construction of the PBCL teaching model, focusing on the design of teaching objectives, integrating cooperative and project-based learning, the provisioning of learning resources and support, and the establishment of evaluation and feedback mechanisms. Building upon this foundation, the study delineates the steps to implement PBCL teaching methods, including pre-class preparations, project initiation, collaborative learning and project implementation, project summarization and evaluation, and post-class extension. Finally, the study analyzes the strengths and limitations of this teaching approach. The strengths include deep learning experiences, enhanced collaborative abilities, and the cultivation of critical thinking skills. However, limitations are evident in the greater practical input and resource demands, inadequacies in the capabilities of some students, and deficiencies in assessment effectiveness.
Schnee und Lawinen in den Schweizer Alpen. Hydrologisches Jahr 2023/24
Authors: Zweifel Benjamin , Techel Frank , Marty Christoph , Stucki Thomas
Published: January 2025

Im vorliegenden Bericht werden die Schnee- und Lawinensituation und Lawinen mit Personen- und Sachschaden beschrieben.
Wetter, Schneedecke und Lawinengefahr
Der erste Teil (Kapitel 2, ab Seite 8) umfasst einen Ruckblick auf die Schnee- und Lawinensituation in den Schweizer Alpen und im Schweizer Jura. Dabei wird auf den Schneehohenverlauf und die wichtigsten Niederschlagsereignisse sowie die bedeutendsten Lawinenperioden mit der Entwicklung des Schneedeckenaufbaus und der Schneedeckenstabilitat eingegangen. Weitere Informationen zu einzelnen Perioden, Gefahren- und Schneehohenkarten konnen im AvaBlog, die vollstandigen Bulletins im Archiv im Internet unter www.slf.ch abgerufen werden.
Lawinen mit Personen- und Sachschaden
Der zweite Teil des Berichtes beinhaltet die Lawinen mit Personen- und Sachschaden (Kapitel 3, ab Seite 38). Nebst einer Zusammenfassung aller uns bekannten Lawinen mit Personen- und Sachschaden des Winters 2023/24 werden auch einige ausgewahlte Unfalle detailliert beschrieben (ab Seite 57).
delincuencia común en la Región de Murcia durante la posguerra civil: evolución general y tipología delictiva
Authors: Gómez Westermeyer Juan Francisco , Puche Gil Javier
Published: January 2025

Este artículo analiza la delincuencia común en la Región de Murcia durante la posguerra civil española. Estudia la tipología delictiva y su evolución temporal. Los libros de registro de causas y sentencias de la Audiencia Provincial de Murcia, y los juicios de faltas celebrados en los juzgados municipales de la provincia constituyen las principales fuentes de estudio. Los datos analizados revelan que en la provincia de Murcia existió una estrecha correlación entre hambre y delitos/faltas contra la propiedad en la década de 1940. En la década de 1950 esta relación pierde intensidad, coincidiendo con el fin del sistema de racionamiento.
Избыточная профессионально-ориентированная среда современной школы как условие раннего профессионального самоопределения обучающихся
Authors: Позднеева Л.П. , Тихонова А.Б.
Published: January 2025

Одним из эффективных способов решения проблемы раннего профессионального самоопределения обучающихся является создание в школе избыточной профессионально-ориентированной среды, которая трактуется как специально организованная среда, обеспечивающая реализацию личностью разнообразных образовательных маршрутов, обусловленных её изменяющимися потребностями. В статье представлена авторская модель такой среды, которая включает нормативный, предметно-содержательный, методический, организационный и контролирующийкомпоненты, характеризуется вариативностью, интерактивностью, комплексностью и требует учёта принципов профессиональной направленности, технологичности, комплексности ресурсного обеспечения, соответствия потребностей личности и общества. Отмечается, что эффективное функционирование модели обеспечивается созданием специальных педагогических условий: 1) применение комплекса учебно-профессиональных задач, способствующих профессиональному самоопределению школьников; 2) формирование у обучающихся основ профессионального самосознания; 3) вариативность образовательных программ и технологий.

One of the effective ways to solve the problem of early professional self-determination of students is to create an excessive professionally oriented environment at school, which is interpreted as a specially organized environment that ensures the implementation of a variety of educational routes by an individual, conditioned by his or her changing needs. The article presents the author's model of such an environment, which includes normative, subject-content, methodological, organizational and control components, is characterized by variability, interactivity, complexity and requires considering the principles of professional orientation, technology, complexity of resource provision, compliance with the needs of the individual and society. It is noted that the effective functioning of the model is ensured by the creation of special pedagogical conditions: 1) the use of a set of educational and professional tasks that contribute to the professional self-determination of schoolchildren; 2) the formation of the basics of professional self-awareness in students; 3) variability of educational programs and technologies.
Las tecnologías de traducción en la gestión de proyectos en España: un estudio basado en corpus
Authors: Fuentes-Pérez Irene , Sánchez Ramos María del Mar
Published: January 2025

Este artículo tiene como objetivo establecer la relación entre las tecnologías de traducción y el gestor de proyectos de traducción en España. Para ello, se ha llevado a cabo un estudio basado en el análisis de un corpus textual formado por ofertas de empleo de vacantes de gestión de proyectos.
Perspectivas y uso de la traducción automática y la posedición en traducción audiovisual: el punto de vista de los profesionales
Authors: Carrero Martín Jose Fernando , Reverter Oliver Beatriz
Published: January 2025

Este estudio recoge las perspectivas de los traductores audiovisuales que trabajan en el mercado español sobre los encargos de posedición de textos audiovisuales. Los resultados muestran las características principales de estos encargos, una oposición generalizada hacia estas prácticas y preocupación por la repercusión en las condiciones laborales y en su futuro profesional.
Translation process in concurrent, collaborative workflows
Authors: Temizoz Ozlem , Gough Joanna
Published: January 2025

Technological innovations bring about new practices, urging translators to transform their work processes. Our knowledge of these processes is based on research, which is related to the tools/workflows prevalent at the time. The advances in technology necessitate constant re-examination of the translation process to understand rapidly changing, contemporary translation production methods. The present article gives us a glimpse into how the translation process changes when translators work collaboratively and concurrently within technological environments that enable synchronous horizontal and vertical collaboration on a single text. It presents reported data on process-related aspects from an online survey of 804 translators. Findings suggest that, in the concurrent workflow, the translation process is very different compared to when an entire text is translated by an individual translator. Notable process-related changes reported include a shift in the distribution of time and tasks across the phases of the translation process, limited self-revision during the drafting phase, earlier segment confirmation, precluded end-[self-]revision, and decreased research time.
As sete regras para obter sucesso na cirurgia dos gliomas da ínsula
Authors: Isolan Gustavo Rassier , Bark Samir Ale , Buffon Viviane Aline , Dini Leandro Infantini , Becker Lia Grub , Malafaia Osvaldo , Vaz Marco Antônio Schlindwein
Published: January 2025

Introdução: O melhor tratamento para gliomas insulares é a ressecção cirúrgica. Essas lesões são de tratamento cirúrgico complexo devido à anatomia da ínsula e sua proximidade com estruturas corticais e subcorticais funcionais e estruturas vasculares. Os esforços para preservar a integridade dessas estruturas baseados, exclusivamente, na anatomia microcirúrgica não garantem que o paciente não apresentará déficit motor ou de linguagem no período pós-operatório.
Objetivo: Apresentar 7 regras para alcançar maior sucesso terapêutico, visando aumentar a sobrevida livre de doença e a qualidade de vida.
Método: Dissecções anatômicas microcirúrgicas insulares e 45 microcirurgias de gliomas insulares basearam a proposta das 7 regras para alcançar ressecção segura e eficaz nesses tumores.
Resultado: As 7 regras foram divididas em 4 anatômicas (ramo fronto-orbital do nervo facial, córtex insular, fissura silviana e artérias lenticulostriadas) e 3 fisiológicas (mapeamento cortical, mapeamento subcortical e cápsula interna).
Conclusão: Considerou-se necessário ter grande domínio anatômico e experiência em monitoramento neurofisiológico para obter resultados satisfatórios nas operações sobre gliomas insulares.
Razvoj kompetenčnega modela za svetovalne delavce
Authors: Kukanja Gabrijelčič Mojca , Zupanc Anja , Željeznov Seničar Maruška
Published: January 2025

Za optimalno in kakovostno opravljanje svojega dela potrebujejo svetovalni delavci znanja in kompetence s področja temeljnih pedagoško-psiholoških in didaktično-metodičnih vsebin, sociale, menedžmenta, inkluzivne pedagogike, komunikacijskih veščin, poznavanja evropske zakonodaje, prava ipd. Z namenom priprave predlogov za oblikovanje kompetenčnega modela za svetovalne delavce, ki ga v slovenskem prostoru še nimamo, smo se v raziskavi osredotočili na stališča svetovalnih delavcev o kompetenčnem modelu pedagogov po Staničiću (2001, v Ledić idr., 2013). Ugotovili smo, da svetovalni delavci za kakovostno opravljanje dela svetovalne službe pripisujejo visoko pomembnost osebnim kompetencam, ki imajo prav tako velik pomen pri implementaciji in nadaljnji modifikaciji kompetenčnega modela v našem prostoru. Najnižjo pomembnost pripisujejo kompetencam evropske dimenzije izobraževanja. Respondenti prav tako ocenjujejo, da je kompetenčni model učinkovito orodje samorefleksije v procesu ugotavljanja lastnih močnih in šibkih področij ter potreb po dodatnem izobraževanju.
Pemberdayaan Rumah Hijau “Asman Kelor” Melalui Implementasi Tong Komposter untuk Pengelolaan Limbah Organik
Authors: Virginia Eka Putri Kinanti  , Kamila Edita Rahma , Lailiyah Nurul , Apriliyah Dwi Estiana , Hanum Atika Muhfida , Parahita Alifia Sabina , Nizar Mohamad Athif , Ramdani Alfian Fathurrahman , Ayuby Muchyiddin Azzhakiya Al , Billah Moch Mu’tashim , Saputri Aininda Surya
Published: January 2025

The problem of household waste management, especially organic waste, has become a pressing issue in RT 14 Bangah Village, Gedangan, Sidoarjo, due to the lack of adequate management. This program aims to empower the community through the innovation of "Tong Komposter" as a solution for processing organic waste into compost. The methods used include socialization, training, and participatory evaluation, supported by collaboration between residents, youth organizations, and the village government. The results show an increase in community awareness and participation in waste management, as well as the production of compost that can be used for local agriculture. A community-based approach with simple technology has a significant impact on the environment and society. This program has major implications for supporting environmental sustainability and providing economic potential for the community.