bluuebunny/crossref_metadata_2025 huggingface dataset:
PROSPECTS FOR THE APPLICATION OF FILLED FUNCTIONAL-GRADIENT EPOXY COMPOSITES IN ROAD CONSTRUCTION
Authors: LANKINA Yulia , NIZINA Tatiana
Published: January 2025

One of the most important tasks of any construction is to ensure durability and wear resistance of structural materials, including span structures. For bridge structures one of the most critical structures are expansion joints and their transition zones. The paper considers the use of epoxy composites with increased climatic resistance as a way to increase the strength of the transition zone of bridge structures. The study is especially relevant when us-ing these materials to strengthen the transition zones of expansion joints of highways. The paper presents the results of research in the field of epoxy composites with increased resistance to UV-irradiation. The study also considers the influence of the degree of filling and granulometric composition of the filler on the exothermicity of the curing process of epoxy composites. Antioxidants of amine and phenolic types, which have a stabilizing effect on epoxy composites under the action of UV-irradiation, are proposed. In addition, the influence of micromarble (microcalcite) - mineral carbonate filler on the reduction of exothermicity of the curing reaction of epoxy composite was considered. As a result, materials with a complex of increased technological and operational properties have been suggested, which can be successfully used for reinforcement of transition zones of expansion joints of highway bridge structures.
Introduction
Authors: Buning Marius , Rijks Marlise
Published: January 2025

Introduction to the special issue 'Printing Privileges in the Early Modern Low Countries'.
Burgerdijk’s Institutionem Logicarum and the Freedom to Print Books of the Dutch School Order
Authors: Van Gompel Stef
Published: January 2025

After the States of Holland passed the School Order of 1625, which listed the schoolbooks which were to be used in the Latin schools, they refused to grant privileges protecting the books that were being prepared for this purpose. In 1626, however, the States-General granted a privilege to one of the books of the School Order, Burgersdijk’s Institutionum Logicarum. While it is often reported that this privilege was subsequently invalidated by the States of Holland, because it did not match their policy that anyone was allowed to print and publish copies of official textbooks, this article establishes that Burgersdijk’s privilege actually endured until the mid-seventeenth century. It was prolonged on two occasions by the States-General, the second time even with endorsement by the States of Holland through an attache. This means that the persistent myth about the supposed absence of privileges for Dutch schoolbooks is not entirely correct. There was obviously a need to protect some textbooks, a need the Dutch authorities also recognised. This included schoolbooks to which new elements (such as notes or indexes) were added and schoolbooks for which there was also a market outside the Latin schools, as was clearly the case for Burgersdijk’s Institutionum Logicarum.
Cross-Border Printing Privileges in the Seventeenth-Century Low Countries
Authors: Lamal Nina
Published: January 2025

Based on the assumption that printing privileges were meant to protect printer-publishers from market competition locally, scholars have primarily studied such privileges in individual states. This article is the first attempt to study printing privileges transnationally, by focusing on the phenomenon of cross-border printing privileges in the seventeenth-century Habsburg Netherlands and the Dutch Republic. I examine both the foreign printers requesting a privilege in the Low Countries and local printers requesting a privilege from a foreign authority. In doing so, this essay analyses why printers were requesting privileges for their books from more than one authority across political borders. Rather than seeing these cross-border privileges solely as a way for printers to expand the reach and commercial viability of their published works, this article demonstrates that, by securing privileges from multiple authorities, printers showed they were able to navigate the market for institutions and complex networks of power. By analysing diplomatic correspondence alongside privilege requests, I demonstrate the crucial role of ambassadors in favouring certain printers and their project. Throughout the seventeenth century, the state and its representatives became involved in securing such privileges from other authorities. This hitherto hidden role of diplomatic agents alerts us both to the fierce competition in a certain segment of the international book market and the importance of managing a state’s international reputation.
"STRENGTHENING THE ANTI-CORRUPTION FACTOR IN THE REFORM OF THE LICENSING SYSTEM "
Authors:   Tashkent State University of Law, Meliyev Khudoyor
Published: January 2025

"The fundamental improvement of licensing and permitting procedures, along with the elimination of bureaucratic barriers, is crucial for creating a favorable environment for entrepreneurship by minimizing corruption risks. The article reveals that in recent years, within the framework of actions and development strategies for the development of Uzbekistan, the licensing and permitting system, which is considered a highly bureaucratic area, has been completely reformed. At the same time, the author analyzed the presence of corruption risks and situations in this area, which is an important component of the ongoing reforms. In particular, in this matter, statistical data was used to demonstrate the level of compliance with the legislation in the field of licensing activities identified through the automated information system “Rule of Law”. Proposals have been put forward to review licensing and permitting procedures through business process reengineering, remove redundant links, consider the issue of refusing some permitting procedures, and conduct surveys through an electronic system.
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ORGANIZATIONAL AND LEGAL ASPECTS OF IMPLEMENTATION OF STATE ENVIRONMENTAL CONTROL
Authors:   Tashkent State University of Law, Akhrorov Adkhamjon
Published: January 2025

The activities of specially authorized bodies carrying out control in the field of ecology and environmental protection, ensuring the rational use of natural resources, are of great importance. Today, the deterioration of the existing environmental situation in our country indicates the low effectiveness of control in the sphere, as well as the improper organization of the activities of regulatory bodies. The need to ensure environmental sustainability and address existing problems in this area requires an analysis of the scientific and legal foundations of the activities of regulatory bodies. This article analyzes the activities of specially authorized bodies that exercise oversight in this area. According to the author, if the financial support of a specific supervisory authority is decided by the executive body or if the normative legal act regulating its activities is approved by the Cabinet of Ministers, as well as if it is created within the structure of a certain ministry, the possibility of directly influencing its activities remains. This, in turn, negatively affects the effectiveness of state environmental control. Therefore, it is proposed that the body exercising state control in the field of ecology should be established under the President, not within the Cabinet of Ministers or any other ministry. Also, at the end of the article, proposals were developed to improve the legislation.
Long-term complete remission of two patients with synchronous liver metastasis from pancreatic cancer and underlying BRCA-2 mutation
Authors: Crapé L , Geboes K , Kortbeek K , Naert E , Hoorens A , Berrevoet F , Van Heddeghem N , Ribeiro S
Published: January 2025

Background: Pancreatic ductal adenocarcinoma (PDAC) has a known poor prognosis. For a select group, those with BRCA mutations, frontline platinum-based therapy and poly (ADPribose) polymerase inhibitors are options that can potentially lead to survival benefit.

Patients and methods: We present 2 cases of patients with BRCAmutated pancreatic cancer with liver metastases that achieved a remarkable long-term complete remission on platinum-based chemotherapy.

Conclusion: Germline testing for BRCA is important in PDAC because it influences treatment choices that impact survival. Complete responses with chemotherapy alone are rarely observed in metastatic PDAC, but may be seen upon treatment with platinum-based therapy.
Atypical anal itching lesion associated with a protruding rectal polyp
Authors: Binet Q , Draguet A.-P. , Stainier L
Published: January 2025

An 83-year-old male presented at the gastroenterology clinic with complaints of anal itching associated with a reducible, protruding rectal mass that had been bleeding on contact for the past few months. Clinical examination revealed two erythematous, slightly nodular, eczema-like lesions measuring 3 cm and 2 cm, extending laterally from the anal margin. (Figure 1, Panel A) A digital rectal exam revealed a small, soft mass in the posterior lower rectum. Total colonoscopy identified a 25 mm sessile polyp classified as CONECCT 2C (1) in the lower rectum (Figure 1, Panel B). Biopsies of the anal margin lesions were obtained using a cold forceps.
PERLINDUNGAN HUKUM MOTIF KAIN TENUN IKAT DAYAK KABUPATEN SINTANG MENURUT UNDANG - UNDANG NOMOR 28 TAHUN 2014 TENTANG HAK CIPTA
Authors: Emanuel Victor
Published: January 2025

The motif of Dayak ikat cloth in Sintang Regency is a communal intellectual right belonging to the Dayak community of Sintang Regency which is a hereditary heritage which is regulated in Law Number 28 of 2014 concerning Copyright. As an intellectual right, Dayak Ikat Woven Fabrics in Sintang Regency are one of 33 Types of Ikat Weaving in Indonesia, and a form of protection that is carried out through data collection on communal rights at the Ministry of Law and Human Rights of the Republic of Indonesia. We did this research using normative juridical research. The results of the study show that the legal protection of the communal intellectual rights of Dayak ikat weaving in Sintang district is only limited to data collection by the Ministry of Education, Culture, Research and higher education, UNESCO.If there is plagiarism of motifs by outside parties (third parties) on the motifs of Dayak ikat cloth in Sintang Regency on modern textile products that are commercial or economic in nature, there is no form of legal protection. Therefore, there needs to bea way out from the Sintang Regency Regional government in the form of a permit by plagiarists or those who imitate the motif, and a kind of compensation or form of royalty to the Sintang Regency Dayak Ikat weavers who are members of their community.Keywords: Legal protection, motives, communal intellectual rights
FAKTOR YANG MENYEBABKAN TERJADINYA TINDAK PIDANA ILEGAL LOGGING BERDASARKAN UNDANG – UNDANG NOMOR 18 TAHUN 2013 TENTANG PENCEGAHAN DAN PEMBERANTASAN PERUSAKAN HUTAN
Authors: Salim Kartika Agus
Published: January 2025

Illegal logging is defined to forest damage by individuals or groups of people, either jointly by logging trees, loading, unloading, removing, transporting, controlling, owning, possessing, controlling, unloading, distributing, illegally smuggling, receiving, buying, selling, exchanging, receiving deposits, and an illegal timber forest product. According to a forestry observer and environmental, the various natural disasters have occurred as a result of forest destruction as or illegal logging. The method of this research is sociological empirical legal research. It is carried out by examining primary data, which is obtained directly at the field.The culture factors, which means human attitudes and legal systems of belief, thought values, and expectations. The mood of the social mind that determines how the law is used, avoided, or misused. Thus, these factors are caused by a lack of public awareness toward the importance of law.There are obstacles and solutions done by officials involved in forest protection efforts in Melawi Regency, namely (1) The communities in middle to lower economic level at Melawi Regency(1) The extent of the forest zone (3) CommunityThe Solutions done by officials involved in forest protection (1) Community Outreach (2) A Forest routinely Patrols (3) Building the awareness of villager toward environment.The government must formulate job opportunities for people living around forests to prevent the illegal logging. The forests law enforcement officials should be keen in deploying personnel due to law enforcement process efficiently.
PELAKSANAAN PEMBINAAN NARAPIDANA RESIDIVIS NARKOTIKA DI LEMBAGA PEMASYARAKATAN KELAS II B SINTANG.
Authors: Hartiana Patrisia Mutia Jersi
Published: January 2025

A recidivist who repeats the same crime could made base ballast the punishment based on provision Article 486 of the Criminal Code. The punishment one third more heavy from threat normal punishment if within enough from 5 years’ time after undergo sentence imposed.The Approach of this study is a sociological approach toward a primary law, secondary and tertiary. According to Peter Mahmud Marzuki, there are numbers of approach namely:1 approach the law (statue approach), to provide study of all constitution and the relevant law regulations. Conceptual approach is based on views and the development of doctrines in law.There are steps of coaching prisoner, namely; a. Admission and orientation or known as Mapenaling (The introduction of environment period). This stage conducted since beginning to 1/3 of period criminal. Coaching is continuation from admission and orientation. This stage conducted if prisoner has lived 1/3 of the time criminal up to 1/2 time the crime with medium security. It forms as personality coaching (mental and spiritual) as well independence coaching. b. Prisoner Assimilation coaching could start off 1/2 time criminal up to 2/3 of period the crime based on the assessment of the coaching penitentiary1 Ibid, p.237team in regarding with progress of physical, mental and skill. In this step the supervision toward prisoner is relatively decrease (minimum security). The assimilation in a manner is literally tricked. It can be classified into two forms: The internal assimilation institution penitentiary and the external assimilation institution penitentiary.c. The integration to public environment is the final step in the process of prisoner coaching known as integration.The obstacles of coaching implementation are in the field of intellectual coaching, skills, guidance on work, and the implementation of assimilation.The humanistic approach (humane) is used to resolved the diversity of ethnic or culture, resolve the excess of occupants’ capacity through build new building.
AS PRÁTICAS PEDAGÓGICAS NOS CURRÍCULOS ESCOLARES NO SISTEMA PRISIONAL: OPORTUNIDADES E DESAFIOS
Authors: Santos Silvana Maria Aparecida Viana
Published: January 2025

Este capítulo abordou o problema das práticas pedagógicas no sistema prisional, investigando as oportunidades e desafios que influenciam sua eficácia. O objetivo geral foi analisar como essas práticas contribuem para a ressocialização dos detentos e identificar melhorias necessárias para sua implementação. A pesquisa utilizou a metodologia de revisão bibliográfica, analisando fontes relevantes sobre a educação no contexto prisional. Os resultados indicaram que, apesar dos desafios estruturais e organizacionais, as práticas pedagógicas, quando adaptadas, têm o potencial de promover a transformação social dos detentos, desenvolvendo suas habilidades cognitivas e emocionais. A análise demonstrou que a capacitação dos educadores e a adaptação dos currículos às necessidades dos detentos são fundamentais para o sucesso dessas práticas. As considerações finais destacaram a importância de políticas públicas que melhorem as condições de ensino nas prisões e a necessidade de estudos futuros que aprofundem a análise dos impactos dessas práticas na reintegração social dos detentos. A pesquisa concluiu que, embora existam desafios significativos, as práticas pedagógicas no sistema prisional oferecem oportunidades reais de transformação e ressocialização, desde que implementadas e avaliadas.
O DESEMPENHO ACADÊMICO DA GERAÇÃO DIGITAL UM ESTUDO CRÍTICO
Authors: Santos Silvana Maria Aparecida Viana
Published: January 2025

O estudo investigou como a geração digital impactou o percurso escolar e quais implicações surgiram para a prática pedagógica dos professores. O objetivo geral foi analisar os impactos dessa geração no ambiente escolar, destacando possibilidades e desafios enfrentados pelos docentes. A pesquisa foi conduzida por meio de levantamento bibliográfico, com base em artigos, livros e periódicos acadêmicos disponíveis em plataformas digitais. O desenvolvimento abordou as características da geração digital, os impactos das tecnologias no processo de aprendizagem e as adaptações necessárias para os professores. Foram discutidos os efeitos cognitivos e sociais da exposição precoce às tecnologias, a relevância da neurociência educacional e estratégias pedagógicas que integram práticas tradicionais e digitais. Além disso, analisaram-se os desafios enfrentados pelos professores na mediação do aprendizado, considerando a necessidade de formação contínua para equilibrar o uso de tecnologias com a promoção do pensamento crítico. Nas considerações finais, constatou-se que o equilíbrio entre práticas tradicionais e digitais, aliado ao uso consciente das tecnologias, favoreceu uma aprendizagem significativa e contextualizada. Concluiu-se que é essencial preparar os professores para atender às demandas da geração digital e sugeriu-se a realização de novos estudos que explorem o impacto socioemocional das tecnologias e a diversidade de contextos educacionais.
APRENDIZAGEM AUTOGERIDA
Authors: Santos Silvana Maria Aparecida Viana
Published: January 2025

O capítulo investigou os aspectos relacionados à aprendizagem autogerida (autodirigida), abordando suas características, vantagens e desvantagens. O problema da pesquisa centrou-se na questão: como a aprendizagem autogerida pode ser implementada de maneira eficaz em diferentes contextos educacionais? O objetivo geral foi analisar os elementos que tornam essa abordagem viável e identificar os desafios associados à sua aplicação. A metodologia adotada foi exclusivamente bibliográfica, utilizando fontes acadêmicas confiáveis para fundamentar as discussões. O desenvolvimento do estudo explorou conceitos fundamentais da aprendizagem autogerida, destacando sua relevância na promoção da autonomia e do aprendizado ao longo da vida. Foram analisados os desafios enfrentados por educadores e alunos, bem como as limitações estruturais que podem dificultar sua implementação, como a falta de acesso a recursos tecnológicos e a necessidade de habilidades de autorregulação. As considerações finais ressaltaram a importância de estratégias pedagógicas equilibradas que combinem autonomia e supervisão, além de apontarem a necessidade de estudos futuros para superar as limitações identificadas.
EDUCAÇÃO BRASILEIRA E TECNOLOGIA: REFLEXÕES, DESAFIOS E POTENCIALIDADES
Authors: Cabral Maria Isabel da Assunção , Costa Emanuel Azevedo
Published: January 2025

No mundo contemporâneo, torna-se difícil não considerar a ferramenta tecnologia na atividade do ser humano, tornando importante refletir sobre melhores formas de utilizá-la no dia a dia, inclusive na educação. O artigo trata-se de uma revisão de literatura, a pesquisa foi realizada durante o segundo semestre do ano de 2023, em Outubro, por meio das bases de dados científicas SciELO e Google Acadêmico. Com a utilização dos descritores “Tecnologia” e “Educação brasileira” por meio do operador booleano “AND”. Foram selecionados como critérios de inclusão os estudos publicados entre 2018 a 2023, a fim de retratar a produção dos últimos 5 anos, em português, sendo artigos, teses e dissertações disponíveis como trabalhos completos e gratuitos. Em relação aos critérios de exclusão, foram delimitados aqueles trabalhos pagos, em outro idioma, incompletos e que fogem da temática proposta. Grande parte dos trabalhos abordam os efeitos das tecnologias sobre o desempenho acadêmico, bem como as dificuldades, desafios encontrados nessa inclusão e os benefícios do seu uso na educação. A tecnologia está inserida na sociedade, e a escola não está imune a isso. Diante disso, professores, gestores e autoridades podem criar espaços para refletir sobre esse fenômeno crescente, traçando melhores estratégias para sua utilização nas instituições de ensino, além da necessidade de investimento em infraestrutura, valorização dos profissionais da educação e disponibilização de formação continuada para os professores.
GOVERNANÇA CORPORATIVA E GESTÃO DO CONHECIMENTO
Authors: Souza Ronaldo Soares de , Bizotto Beatriz Lucia Salvador
Published: January 2025

O artigo aborda a interseção entre governança corporativa, gestão do conhecimento e sustentabilidade, destacando sua relevância para a criação de valor organizacional e práticas de gestão inovadoras. A governança corporativa promove transparência, ética e alinhamento estratégico entre os stakeholders, enquanto a gestão do conhecimento organiza e sistematiza o saber, impulsionando a inovação e a sustentabilidade. A pesquisa enfatiza que a educação ambiental contribui para práticas organizacionais conscientes, integrando responsabilidade social e transformação ambiental. Com base em metodologias qualitativas e exploratórias, o estudo explora a interdependência entre categorias como empreendedorismo sustentável e interdisciplinaridade, oferecendo subsídios teóricos para uma gestão organizacional mais eficiente e ética.
"NAVEGAR É PRECISO”, O USO DA TECNOLOGIA EM SALA DE AULA: NUANCES DE UMA ESCOLA PÚBLICA EM SANTA CATARINA
Authors: Silva Deonilde da , Leal Débora Araújo
Published: January 2025

Importa esclarecer, desde logo, que a tecnologia vem desempenhando um papel bastante relevante quando o assunto diz respeito à educação, sendo que a utilização dos mecanismos, especialmente em decorrência do uso de games, demonstra um aspecto bastante relevante quando o assunto consiste na instituição de melhorias na educação, promovendo maior engajamento e preparando os alunos para o futuro. Diante disso, o objetivo geral desta pesquisa acadêmica é promover uma análise a respeito da integração do processo educativo no Ensino Fundamental I, valendo-se, para tanto, dos recursos educacionais que se encontram disponíveis. Já os objetivos específicos são: observar as plataformas educacionais interativas, bem como os recursos digitais no currículo do Ensino Fundamental I; e, promover uma discussão a respeito da capacitação dos professores que atuam no Ensino Fundamental I, de maneira que as ferramentas digitais possam efetivamente ser utilizadas como forma de contribuir para o desenvolvimento das habilidades dos discentes. Justifica-se a realização desta pesquisa acadêmica, eis que, diante do manifesto crescimento da tecnologia no campo da educação, torna-se indiscutível a importância no sentido de observar a contribuição que os meios tecnológicos podem conferir ao processo de ensino-aprendizagem. Para tanto, a metodologia empregada nesta pesquisa é a revisão bibliográfica, por meio da abordagem qualitativa.
Improving JULES Soil Moisture Estimates through 4D-En-Var Hybrid Assimilation of COSMOS-UK Soil Moisture Observations
Authors: Visweshwaran Ramesh , Cooper Elizabeth , Dance Sarah L.
Published: January 2025

Abstract. Accurate soil moisture estimates are essential for effective management and operational planning in various applications, including flood and drought response. However, soil moisture values derived from land surface models often exhibit significant deviations from in-situ observations. Data assimilation combines model information with observations to enhance prediction accuracy. Previous studies have typically focused on either estimating the initial soil moisture state or optimizing Pedotransfer Function (PTF) constants, which link soil texture to the hydraulic properties of the land surface models. In contrast, in this study, we employ a novel approach by performing joint state-parameter assimilation for the JULES model. We optimized both the PTF constants and the initial soil moisture conditions simultaneously. Using Four-Dimensional Ensemble Variational hybrid data assimilation, we ingested field-scale soil moisture observations from the Cosmic-ray Soil Moisture Monitoring Network across 16 diverse sites in the UK. The results demonstrate that joint state-parameter assimilation significantly enhances the accuracy of soil moisture estimates, improving the average Kling Gupta Efficiency values from 0.33 to 0.72 across different soil characteristics. These findings indicate that our proposed joint state-parameter assimilation framework holds great potential for enhanced predictive accuracy in land surface models.
Machine learning of Antarctic firn density by combining radiometer and scatterometer remote-sensing data
Authors: Li Weiran , Veldhuijsen Sanne B. M. , Lhermitte Stef
Published: January 2025

Abstract. Firn density plays a crucial role in assessing the surface mass balance of the Antarctic ice sheet. However, our understanding of the spatial and temporal variations in firn density is limited due to (i) spatial and temporal limitations of in situ measurements, (ii) potential modelling uncertainties, and (iii) lack of firn density products driven by satellite remote-sensing data. To address this gap, this paper explores the potential of satellite microwave radiometer (Special Sensor Microwave Imager/Sounder (SSMIS)) and scatterometer (Advanced Scatterometer (ASCAT)) observations for assessing spatial and temporal dynamics of dry-firn density over the Antarctic ice sheet. Our analysis demonstrates a clear relation between density anomalies at a depth of 40 cm and fluctuations in satellite observations. However, a linear relationship with individual satellite observations is insufficient to explain the spatial and temporal variation in snow density. Hence, we investigate the potential of a non-linear random forest (RF) machine learning approach trained on radiometer and scatterometer data to derive the spatial and temporal variations in dry-firn density. In the estimation process, 10 years of SSMIS observations (brightness temperature) and ASCAT observations (backscatter intensity) is used as input features to a random forest (RF) regressor. The regressor is first trained on time series of modelled density and satellite observations at randomly sampled pixels and then applied to estimate densities in dry-firn areas across Antarctica. The RF results reveal a strong agreement between the spatial patterns estimated by the RF regressor and the modelled densities. The estimated densities exhibit an error of ±10 kg m−3 in the interior of the ice sheet and ±35 kg m−3 towards the ocean. However, the temporal patterns show some discrepancies, as the RF regressor tends to overestimate summer densities, except for high-elevation regions in East Antarctica and specific areas in West Antarctica. These errors may be attributed to underestimations of short-term or seasonal variations in the modelled density and the limitations of RF in extrapolating values outside the training data. Overall, our study presents a potential method for estimating unknown Antarctic firn densities using known densities and satellite parameters.
Frequency and Association of Perforated Appendix with Patient’s Characteristics in Acute Appendicitis
Authors: Zeb Muhammad , Ahmad Rafia , Wadood Abdul , Ahmed Shtiaq , Hassan Malak Maaz , Farooq Muhammad Moazzam
Published: January 2025

Objective: To determine the frequency of perforated acute appendicitis in patients with acute appendicitis and its association with patients clinic demographic characteristics.
 
Study design and setting: This cross sectional study was conducted in general surgery unit from 1st January 2022 to 31st December 2022.
 
Methodology: 171 patients were included. Patients who were provisionally diagnosed as acute appendicitis were included in the study. Sampling technique was nonprobability consecutive sampling. Statistical analysis was done through SPSS Version 23.
 
Results: The study included 171 patients, with 58.5% male and 41.5% female. The majority of patients were aged between 25-35 years and had a normal weight. Grossly inflamed appendix was the most common finding (69.6%), followed by perforated appendix (19.3%), normal appendix (8.2%), and gangrenous appendicitis (2.9%). There was no statistically significant difference between gender and intraoperative findings. Age categories and duration of symptoms were significantly associated with intraoperative findings.
 
Conclusion: In conclusion, 19.3% of patients with acute appendicitis presented with perforation. Age and duration of symptoms were found to be significantly associated with intraoperative findings, highlighting the importance of early diagnosis and timely surgical intervention
Anticancer Activity of n-Hexane and Acetone Leaf Extracts from Delonix regia (Gul Mohar) on HeLa (Cervical) and Prostate Cell Lines
Authors: Sheikh Saeed Ahmed , Ahmed Asif , Ullah Asad , Nawaz Shazia
Published: January 2025

Objective: The purpose of this study was evaluation of the anticancer activity of n-hexane and acetone leaf extracts obtained from Delonix regia on BJ, cervical (HeLa), and prostate cell lines.
Study Design and Setting: This in vitro study was designed to assess the cytotoxic effects of leaf extracts from D. regia. The leaves were harvested, dried, and then subjected to extraction using hexane and acetone. The resulting extracts were concentrated and prepared for analysis. The effects of these extracts were evaluated on HeLa and prostate cell lines under standard laboratory conditions.
Methodology: MTT colorimetric assay was used to evaluate the cytotoxic activity of leaf extracts. Cell cultures were prepared and introduced into the plates. Different concentrations of extracts were added, and reduction of MTT to formazan within cells was measured. The cytotoxicity was monitored as the concentration causing 50% growth inhibition (IC50) for cell lines.
Results: Results show that the acetone extract exhibits moderate inhibition (36.29%) on cervical cell lines, while the nhexane extract demonstrates higher inhibition (55.84%) on the same cell line. However, both extracts are inactive on prostate cell lines. On BJ cell lines, both extract showing significant inhibition (69.68% & 61.32%) respectively.
Conclusion: In conclusion n-hexane extracts of D. regia exhibited more cytotoxic activity than acetone leaf extract. Although, D. regia possessed some anticancer activity potential however its efficacy is not comparable to doxorubicin. The study suggests further exploration of acetone and n-hexane extracts from D. regia as potential anticancer agents
The Evolving Role of Genetic Counseling in Genomic Medicine
Authors: Tarrar Ghulam Hassam U Din , Mushtaq Nimra , Muzamil Muhammad
Published: January 2025

Genetic counseling involves educating at-risk patients or their close relatives about the occurrence of genetic diseases, their likelihood, and treatment, including ways to prevent or cure them. Counsellors will discuss the genetics and treatment of the disease, as well as the personal, familial, social and insurance implications. Additional diagnostic procedures, such as genetic testing, may be recommended to better understand risks or confirm the diagnosis
Aesthetic Management of Coronal Dilacerations with Enamel Hypoplasia of Permanent Maxillary Central Incisors:
Authors: Amir Nehal , Hayat Muqadus
Published: January 2025

Dilaceration is a peculiar developmental dental anomaly. It is associated with traumatic events of deciduous teeth affecting the permanent tooth buds. It is chiefly a precipitous change in the axial inclination between the crown and the root of a tooth. Dilacerated crown, a rare clinical presentation, is a result of the non-axial displacement of pre-formed hard tissues of a developing crown at an angle to its longitudinal axis. It conspicuously impacts the appearance of patient. Enamel hypoplasia is primarily due to the trauma or infection of primary predecessor tooth resulting in a quantitative defect in enamel of permanent successors. Occasionally, both conditions; dilacerated crown and enamel hypoplasia can occur concomitantly producing many unpropitious outcomes. This particular case is about a 14-year-old boy presenting to the Department of Operative dentistry and Endodontics for the esthetic management of anomalous maxillary central incisors. These anomalous teeth were conservatively managed using direct composite veneers.
Limitations of Artificial Intelligence in Orthodontics. Literature Review
Authors: Naureen Sadia
Published: January 2025

In the 21st century, advances in computer technology and data science have brought significant innovation to orthodontics, especially through Artificial Intelligence (AI) and Machine Learning (ML). This study, conducted from July 2 to August 15, 2024, in the Orthodontic Department at Rawal Institute of Health Sciences Islamabad, reviews AI’s transformative role in dentistry, focusing on its applications, benefits, and challenges. A comprehensive literature search across PubMed and Google Scholar yielded 260 peer-reviewed articles from 2001 to 2024. After applying stringent selection criteria, the review focused on AI's historical development, applications, and limitations in orthodontics. While AI enhances diagnostic imaging and patient care, it cannot replace clinical expertise. Key challenges include patient privacy, data security, and ethical considerations. AI systems rely heavily on high-quality data, necessitating rigorous training. Therefore, AI should be viewed as an adjunct in orthodontics, providing a “second opinion” to support clinical decisions.
“Who am I?” The HiddenAspects of Dissociative Identity Disorder
Authors: Eman Alishba
Published: January 2025

Dissociative identity disorder (DID) is a persistent posttraumatic condition marked by impaired memory and selfidentity functions resulting from childhood trauma. It is a severe chronic psychiatric illness characterized by neurobiological, cognitive, and interpersonal disintegration in reaction to intolerable stress. Dissociative Identity Disorder (DID) remains inadequately researched; nevertheless, more investigation may elucidate neurobiological and cognitive characteristics, as well as the interplay between individuals and environmental stressors
ЗАБЕЗПЕЧЕННЯ В УКРАЇНІ ПРАВ ЛЮДИНИ, ПОРУШЕНИХ ВНАСЛІДОК ЗБРОЙНОЇ АГРЕСІЇ РФ
Authors: Стефанчук Руслан Олексійович
Published: January 2025

Статтю присвячено аналізу сучасного стану забезпечення прав людини в Україні, а також перспектив пошуку шляхів відновлення прав людини, порушених внаслідок збройної агресії рф проти України, та вдосконалення чинного законодавства з цією метою. Зауважено на порушенні основоположних прав людини в Україні агресором та необхідності застосовування різних правових засобів для їх захисту та відновлення. Наголошено на заходах, які здійснює наша держава для відновлення порушених прав людини та їх подальшого забезпечення. Окреслено формування правового механізму відшкодування збитків, завданих збройною агресією рф проти України. Першим кроком на цьому шляху визначено створення міжнародного Реєстру збитків у Гаазі. Оптимальним правовим інструментом запровадження механізму відшкодування шкоди, завданої російською агресією проти України, є можливість використання як російських суверенних, так і приватних активів. Аналіз судової практики засвідчує можливість обмеження абсолютного імунітету держави-агресора у справах про відшкодування шкоди. Зроблено висновок, що відновлення більшості порушених російським агресором прав людини в Україні здійснюється та буде здійснюватися на компенсаторних засадах. Підкреслено важливість завершення процесу формування повноцінного правового механізму відшкодування збитків за міжнародної підтримки партнерів України. Доведено, що відповідальність за шкоду, заподіяну населенню України, повинна понести російська федерація.
ЗАГАЛЬНА ХАРАКТЕРИСТИКА ЕЛЕМЕНТІВ АДМІНІСТРАТИВНО-ПРАВОВОГО МЕХАНІЗМУ РЕАЛІЗАЦІЇ ДЕРЖАВНОЇ ПОЛІТИКИ У СФЕРІ ЗАБЕЗПЕЧЕННЯ ЕКОНОМІЧНОЇ БЕЗПЕКИ ДЕРЖАВИ ПІД ЧАС ВОЄННОГО СТАНУ
Authors: Лиманюк Андрій Анатолійович
Published: January 2025

У статті автором обґрунтовано власний погляд щодо структури адміністративно-правового механізму реалізації державної політики у сфері забезпечення економічної безпеки держави під час воєнного стану, відповідно до якого її елементами є: 1) норми адміністративного права, які регламентують такі основні напрями, як-от: функціонування економічної сфери держави, зокрема виробничий, фінансовий, інвестиційний, продовольчий сектори; діяльність суб’єктів реалізації державної політики у сфері забезпечення економічної безпеки держави; управлінські та інші процедури, що виникають під час реалізації вказаного виду державної політики; специфіка функціонування національної економіки та компетентних суб’єктів, які забезпечують її безпеку в умовах воєнного стану; правовідносини, що виникають в окресленій сфері; стабілізація соціальної сфери в частині аспектів, які впливають на розбудову економіки країни; 2) принципи забезпечення економічної безпеки держави під час воєнного стану, система яких містить не тільки загальні та спеціальні принципи права, а й економічні, управлінські та інші засади; 3) суб’єкти реалізації державної політики у сфері забезпечення економічної безпеки держави під час воєнного стану, коло яких стає ширше з урахуванням особливих умов, що обумовлюється необхідністю залучення різнопрофільних органів, у тому числі створених у цей період, для комплексного підходу до вирішення завдань, пов’язаних із забезпеченням економічної безпеки держави; 4) правові відносини, які виникають між компетентними суб’єктами та іншими органами публічної адміністрації, громадянами та їх об’єднаннями під час реалізації державної політики у сфері забезпечення економічної безпеки держави в умовах дії воєнного стану, що матимуть свою специфіку внаслідок розширеного суб’єктного складу та їх кола повноважень; 5) інструменти, за допомогою яких реалізується державна політика у сфері забезпечення економічної безпеки держави в умовах дії воєнного стану, насамперед йдеться про форми, методи, а також інші засоби, способи та ресурси (матеріально-технічні, кадрові, оперативні), що використовуються в процесі окресленого кола діяльності; 6) процедури державної політики у сфері забезпечення економічної безпеки держави в умовах дії воєнного стану, які характеризуються різноманітним змістом і сферами реалізації, а їх результатом є проведення конкретних заходів для стабілізації, розвитку національної економічної системи, а також її охорони та захисту від реальних і потенційних загроз.
ОСОБЛИВОСТІ СУДОВОГО РОЗГЛЯДУ СПРАВ ПРО РОЗІРВАННЯ ШЛЮБУ
Authors: Мельник Олександр Сергійович
Published: January 2025

Стаття досліджує загальне поняття доказів і поняття доказів безпосередньо у справах про розірвання шлюбу. Якщо щодо теми доказів і порядку їх збирання, надання їм оцінки судом існує певна кількість публікацій, то щодо доказів у процесі розірвання шлюбу таких публікацій невелика кількість. Тому тема дослідження є маловивченою і потребує всебічного та додаткового дослідження. Також тема цієї статті є актуальною через те, що, хоча і наявна практика Верховного суду України від 2022 року, яка застерігає від надмірного формалізму у справах про розірвання шлюбу, зокрема, щодо витребування оригіналу свідоцтва про шлюб, суди перших інстанцій і надалі, два роки поспіль, включно до жовтня 2024 року, необґрунтовано витребують оригінали документів для підтвердження факту укладення шлюбу. У цій публікації автор спробує розібратися в сутності доведення в цивільних справах, зокрема в справах про розірвання шлюбу. Актуальність вибраної теми також підтверджується тим фактом, що внаслідок повномасштабної війни велика кількість документів може бути назавжди знищена чи втрачена. Крім того, проблемою стало перебування вказаних документів на непідконтрольних територіях, а самих позивачів, які за законом зобов’язані доводити обставини, на які вони посилаються в заявах до суду конкретними доказами, – за кордоном. Ця тема мала б меншу дослідницьку цінність, якби судові органи не створювали умов, за яких позивачі мають надавати суто оригінали чи дублікати втрачених документів, хоча факти, які вони встановлюють, а саме факт укладення шлюбу, визнаються сторонами спору та відсутній обґрунтований сумнів у їх достовірності. Проте суди вимагають оригіналів документів, часто залишаючи без руху заяви позивачів, що порушує законні права заявників на справедливий суд. Предметом цієї публікації є також дослідження практики Європейського суду з прав людини та її формалізму й забезпечення прав заявників на доступ до суду.
ДОКТРИНА НАЦІОНАЛЬНОЇ БЕЗПЕКИ І ОБОРОНИ УКРАЇНИ ПОВОЄННОГО ПЕРІОДУ: ПРОБЛЕМИ ФОРМУВАННЯ
Authors: Кот Олексій Олександрович , Гриняк Андрій Богданович
Published: January 2025

Статтю присвячено обгрунтуванню необхідності оновлення питань, присвячених формуванню доктрини національної безпеки і оборони України в умовах воєнної агресії Росії та повоєнного відновлення України. На основі ретроспективного аналізу подано минулий досвід України із формування стратегічних документів національної безпеки і оборони. Детальне коротко, середнє та довгострокове планування національної безпеки і оборони держави пов’язане із потребою визначення пріоритетів, завдань, засобів та способів забезпечення національної безпеки і оборони шляхом пошуку балансу між існуючими та потенційними загрозами та фінансово-економічними можливостями держави. Напрацювання доктрини національної безпеки і оборони дозволить створити методологічну основу нормотворчої діяльності, стратегічного планування, розбудови структури сил і засобів національної безпеки і оборони, сприятиме подальшій інтеграції України в євроатлантичний простір. Виокремлено керівні документи національної безпеки і оборони України: 1) концепція (провідний задум); 2) доктрина (теорія, система принципів, поглядів, настанов); 3) стратегія (конкретні рішення, цілі). Формування стратегії національної безпеки і оборони відбувається через механізм керування ризиками виникнення таких загроз. При формуванні власної системи зовнішніх та внутрішніх загроз держава закладає потенційні інструменти їх усунення та подолання, виходячи насамперед із національних інтересів, які охоплюють потреби українського народу у збереженні та розвитку української державності та національних цінностей. Від правильності їх вибору залежить й воєнна організація країни через розбудову відповідних державних органів, військових формувань, діяльність яких безпосередньо спрямована на захист національних інтересів. Наведене потребує опрацювання та закріплення на доктринальному рівні з метою підготовки нової Стратегії національної безпеки і оборони України повоєнного періоду. З цією метою вітчизнана наукова думка уже сьогодні повинна піднімати важливі питання як стратегічного, так і оперативного значення з метою формування дієвої доктрини національної безпеки та оборони країни. Без систематичного розроблення та ґрунтовного осмислення цього комплексу проблем неможливо окреслити й запропонувати оптимальні засади державної політики в цій сфері.
The Acute Effects of Antagonist Static Stretching on Agonist Performance
Authors: Bahrami Mohammadmahdi , Rahmani Hiwa , Button Duane C. , Konrad Andreas , Behm David G.
Published: January 2025

Stretching the antagonist muscle to enhance agonist performance has gained considerable attention. However, most studies have focused on one stretching duration. Hence, the aim of this study was to compare varying durations (40-, 80-, and 120-seconds) of antagonist (dorsiflexors) static stretching (SS) on agonist (plantar flexors: PF) muscle performance. In this randomized crossover study, 16 participants (six females) underwent four sessions (40-, 80-, 120-s dorsiflexors SS and control), with pre- and post-intervention measurements of slow (600/s) and fast (2400/s) PF isokinetic, isometric peak torque, total work, stiff leg drop jump (SDJ) performance (height, reactive strength index (RSI) and peak power), and tibialis anterior and soleus electromyography (EMG). Dorsiflexors SS protocol involved 1x40-s (40-s), 2x40-s (80-s), and 3x40-s (120-s). There were no significant pre- to post-intervention changes in any parameter. A main effect for time demonstrated an overall decrease in fast (p < 0.0001, 5.9%, d = 0.24) and slow (p = 0.05, 6.6%, d = 0.24) isokinetic peak torque, total work (p = 0.02, 5.1%, d = 0.20) and all SDJ measures (SDJ height: p = 0.02, 2.7%, d = 0.15, RSI: p < 0.0001, 5.9%, d = 0.23, peak power: p = 0.002, 4.4%, d = 0.22). Soleus EMG decreased from pre- to post-SS after 120-s in both isometric (p = 0.002, 13.6%, d = 0.73) and slow isokinetic (p = 0.002, 12.3%, d = 0.91) peak torque as well as 80-s with slow isokinetic peak torque (p = 0.02, 6.6%, d = 0.75). In summary, different durations of dorsiflexors SS (40-s, 80-s, 120-s) did not significantly influence PF performance. However, deficits associated with a main effect for time suggested possible testing effects as detected with the control condition.
Sobre el valor integral de la economía social y solidaria y la economía de Francisco
Authors: Alarcón Conde Miguel Ángel
Published: January 2025

El artículo intenta estudiar la convergencia entre los principios de la Economía de Francisco (EdF) y la Economía Social y Solidaria (ESS) desde el enfoque del institucionalismo económico. La EdF propone una economía ética, centrada en el bien común, justicia social y sostenibilidad, en contraste con el modelo económico tradicional enfocado en el lucro individual. La ESS, por su parte, ofrece un modelo inclusivo y cooperativo que prioriza el bienestar colectivo. Mediante un análisis detallado, el trabajo explora cómo principios de la EdF, como la paz, el cuidado ambiental y el respeto cultural, se alinean con los valores comunes de la ESS. Además, clasifica esta relación en tres niveles de intensidad (fuerte, moderada y débil), reflejando la afinidad entre ambos modelos. La investigación concluye que la ESS proporciona una estructura organizativa concreta que puede materializar los ideales de la EdF, promoviendo una economía que responde a necesidades sociales y ambientales. El estudio incluye evidencia de investigaciones sobre el impacto económico y social de empresas de la ESS en Colombia y su contribución a transformar vidas. También sugiere enfoques alternativos al PIB para valorar los aportes integrales de estas entidades y para orientar políticas públicas que promuevan la sostenibilidad y la justicia social
El Impacto de la Pérdida Auditiva en las Habilidades de Función Ejecutiva
Authors: Marrodan Elisa , De Diego-Lázaro Beatriz
Published: January 2025

Los niños con pérdida auditiva (PA) portadores de implantes cocleares pueden mostrar dificultades en las habilidades de función ejecutiva (FE), pero se desconoce si estas limitaciones están presentes en niños con menor grado de PA portadores de audífonos. Este estudio tiene por objetivos evaluar cómo afecta el grado de PA a la FE e identificar qué factores la predicen. Un total de veintiséis niños con audición normal, 16 con hipoacusia (portadores de audífonos) y 15 con sordera (portadores de implantes cocleares) entre 4 y 8 años completaron pruebas auditivas, de vocabulario y de FE (directas e indirectas).  Los ANOVAS mostraron diferencias significativas por estatus auditivo en control inhibitorio (medida directa efecto de interferencia Stroop). Los niños con audición normal presentaron mejor control inhibitorio que los niños con PA (implantes cocleares y audífonos), pero no hubo diferencias entre niños con implantes cocleares y audífonos. Las regresiones estadísticas mostraron que, después de controlar por factores demográficos, la edad de producción de la primera palabra predecía significativamente varianza en las medidas de FE. Se concluye que cualquier grado de pérdida auditiva podría afectar negativamente a las habilidades de FE, concretamente al control inhibitorio. La edad de producción de la primera palabra es una medida fácil de obtener y podría ser una variable importante para predecir habilidades de FE en niños con PA.