bluuebunny/crossref_metadata_2025 huggingface dataset:
Intraterritorial differences in reproductive losses
Authors: Mateykovich E. A. , Novikova V. A. , Radzinsky V. E.
Published: August 2023

Introduction. Postponing motherhood correlates with a decrease in natural fertility, the accumulation of aggravated reproductive experience, somatic and other diseases, and, as a result, an increase in the risk of reproductive losses. The present study reflects the significance of intraterritorial differences in the structure and frequency of reproductive losses among female residents of the Tyumen region. Aim. To assess intraterritorial differences in reproductive losses on the example of the Tyumen region.

Materials and methods. An analytical study has been carried out. The study period is 2016–2021. Reproductive losses in various autonomous districts of the Tyumen region were analyzed. Used data from medical records.

Results and discussion. In Tyumen region, 94.33% of reproductive losses occur before 12 weeks of gestation. The proportion of primigravidas in the total number of reproductive losses is 6.78%, HIV-infected – 2.06%. Reproductive losses in the first pregnancy is associated with a gestational age of more than 12 weeks (OR 2.31, 95% CI 2.13–2.49), with HIV infection – less than 12 weeks (OR 3.59, 95% CI 2, 88–4.47). Tyumen region without AO is characterized by a greater association of reproductive losses in pregnancy up to 12 weeks with HIV infection in comparison with the Khanty-Mansiysk Autonomous Okrug – Yugra (KhMAO): OR 1.83, 95% CI 1.67–2.00; and Yamalo-Nenets Autonomous Okrug (YNAO): OR 7.68, 95% CI 6.01–9.81; from 12 to 22 weeks – with HIV infection compared with KhMAO (OR 1.93, 95% CI 1.20–3.09) and YNAO (OR 3.0, 95% CI 1.30–6, 95), with a first pregnancy compared with KhMAO (OR 1.26, 95% CI 1.07–1.48) and YNAO (OR 1.81, 95% CI 1.40–2.35). The greatest contrast was noted between Tyumen region and YNAO. More than 50% of reproductive losses in pregnancy before 12 weeks is due to medical abortion. In Tyumen region without autonomous regions, at more than 12 weeks of gestation, medical abortion competes in frequency with spontaneous abortion. Tyumen region without AO showed high achievements in the total overcoming of criminal abortion.

Conclusion. On the example of Tyumen region, the non-universality of the intra-territorial structure of the Republic of Poland is shown. Artificial reproductive losses dominate over non-artificial ones. Intraterritorial differences in reproductive losses require taking into account, monitoring many risk factors, adapting measures for their prevention, preservation and restoration of reproductive health to them.
Antihypertensive therapy following glaucoma valve implantation: analysis of the effectiveness of carbonic anhydrase inhibitors and prostaglandin analogues
Authors: Rascheskov A. Yu. , Loskutov I. A. , Korneeva A. V. , Yafyasova A. F. , Strakhova S. S.
Published: August 2023

Introduction. The Ahmed glaucoma valve (GV) type drainage implantation is characterized by high efficiency and low complication rate, and is finding an increasing application in clinical practice. Although GV provides better intraocular pressure (IOP) control and higher surgical success rates compared to trabeculectomy, the so-called hypertensive phase (HP), typically defined as an IOP elevation more than 21 mmHg, can occur at the period from one to three months postoperatively, related to the fibrous capsule reservoir formation, which does not have the character of persistent hypertension.

Aim. To analyze the effectiveness of the Dorzolamide-Optic carbonic anhydrase inhibitor and the Latanoprost-Optic prostaglandin analogue as the drugs of choice in clinical conditions at different periods during postoperative follow-up when antihypertensive therapy after GV implantation is needed.

Materials and methods. The study included 80 glaucoma patients who underwent GV implantation in the clinic “Eye Surgery Rascheskov” with a postoperative follow-up period of at least one year. In order to increase the effectiveness of surgical intervention and preserve visual functions, hypotensive therapy was prescribed in studied patients either when IOP exceeded the target pressure, or when there was a tendency to a constant increase between control visits. 180 operated patients with IOP level within the target level during the follow-up period were excluded from the study.

Results. The overall incidence rate of the hypertensive phase (GF) was 44.4%. In all studied patients to compliance with the operation technique and early therapy appointment, Dorzolamide-Optic monotherapy was sufficient to achieve stabilization of visual functions for up to 3 months after surgery. During a follow-up period more than 3 month, 15 patients (18.8%) required additional appointment of Latanoprost-Optic to achieve the target IOP level. After 2 months following the implantation, the antihypertensive therapy was discontinued under the IOP control in 17 patients (21.3%).

Conclusions. Medical management of HP is crucial for preventing further optic nerve damage and preserving visual functions, as reduction of the incidence and severity of HP are known to be associated with higher operative success rates and a better long-term IOP control.
Assessment of the quality of life of patients with gonarthrosis treated with a prosthesis of synovial fluid of domestic production
Authors: Sivordova L. E. , Polyakova Yu. V. , Papichev E. V. , Akhverdyan Yu. R. , Zavodovskii B. V.
Published: August 2023

Introduction. Osteoarthritis (OA) is a chronic progressive disease of the joints, accompanied with pain, which limits the mobility of patients. Functional limitations, chronic pain syndrome worsen the quality of life (QoL) in OA of the joints of the lower extremities. QoL significantly depends on the effectiveness and methods of pain treatment, correction of functional disorders.

Aim. Evaluation of the dynamics of QoL in patients with gonarthrosis treated with a high-tech synovial fluid prosthesis – sodium hyaluronate, domestic production.

Materials and methods. The study group consisted of 50 patients who received intra-articular (IA) injections of domestically produced sodium hyaluronate (OOO Ingal, Russia). Comparison group – 30 patients treated with 2 ml of symptomatic drugs of delayed action (SYSADOA) (bioactive concentrate of small marine fish) administrated IA No. 5. Control group – 100 patients treated with a 1 ml of SYSADOA drugs administrated intramuscularly (IM) No. 20. Study program: 12 months, 6 visits with prospective monitoring of the quality of life of patients according to SF-36 compared with baseline data.

Results. At the time of inclusion, patients had a similar level of physical and mental health components, which did not differ statistically significantly (p = 0.369 and p = 0.089). The study group demonstrated the best dynamics of the physical and mental components of health. The therapy was effective in all groups: most patients showed a statistically significant decrease in pain syndrome, an increase in QoL. The groups differed significantly in the speed of achieving the effect of pain relief, the severity of pain reduction and the duration of the effect of treatment.

Conclusions. The spectrum of side effects of non-steroidal anti-inflammatory drugs (NSAIDs) does not allow their use for pain relief indefinitely. SYSADOAs become less effective in the progression of OA than in the early stages of the disease. The positive clinical effect of intra-articular injection of sodium hyaluronate solutions occurs faster and lasts longer than when using SYSADOA.
Results of glycaemic control on exertion in children with type 1 diabetes mellitus in FOX children's recreational camp settings
Authors: Bolotskaya L. L. , Golubkina Yu. Yu. , Frolova T. M.
Published: August 2023

ANO “Children’s Camp FOX CAMP (Lager’ Lisonok)” has been operating in Russia since 2019. Changes of observations in the Moscow region, Sochi, Kaliningrad region, Sochi, Gelendzhik, Chelyabinsk region, Altai. In the period from 2019 to 2022, 796 children and adolescents with type 1 diabetes mellitus (DM1) visited the shifts and active tours of the ANO “Children’s Camp FOKS CAMP (Lager’ Lisonok)”. The priority of children’s recreation is a focus on increased activity: marathons at various distances, football matches, basketball, alpine skiing and long hikes in the mountains, rafting. It is known that activity in patients with type 1 diabetes increases sharply by the level of blood increase, by a decrease in this indicator. In order, to prevent the development of hypoglycemia during heavy exercise, it is very important to quickly determine blood glucose using a glucometer and take the necessary measures to stop it. Thus, the presence of sufficient shifts is necessary to quickly and accurately carry out self-monitoring, sometimes in various and difficult conditions (on mountain trails, on a suspension bridge, when rafting on a mountain river, on the beach). This article presents the development of events on elevated blood levels in children and adolescents with DM1 in the conditions of the marathon, running at various distances in the conditions of the summer shift in the Moscow region of the children’s health camp ANO “Children’s Camp FOX CAMP (Lager’ Lisonok)”.
Clinical features of dry eye syndrome and evaluation of the effectiveness of artificial tear therapy in patients with anxiety and depression after cataract and keratorefractive surgery
Authors: Korneeva A. V. , Strakhova S. S. , Loskutov I. A.
Published: August 2023

Introduction. Dry eye syndrome (DES) is a common cause of blurred vision and discomfort in patients after eye surgery, which has a great impact on the on the patients’ mental state. Evaluation of the presence of DES during the preoperative examination is important not only for obtaining a high postoperative result, but also for the timely administration of therapy in order to improve the patient's quality of life.

Aim. Thus, the aim of this study was to establish the features of the clinical course of dry eye syndrome and to determine the effectiveness of ultra-high viscosity hyaluronic acid therapy in patients with anxiety and depression after cataract and keratorefractive surgery.

Materials and methods. The study involved 100 patients (150 eyes). Preoperative examination included DES diagnostic and psychotesting. DES in all studied subjects was treated with ultra-high viscosity hyaluronic acid 3 times a day for 3 months after surgery in combination with topical combination of glucocorticoids, antibacterial and non-steroidal anti-inflammatory drugs, which were administered within 1 week after surgery. There were no intraoperative complications in all studied cases.

Results. It was found that patients with depressive and/or anxiety symptoms (46% of the subjects) had higher OSDI scores, while there were no differences in clinical and functional tests of dry eye syndrome between the studied groups. There was a significant improvement in the results of OCT meniscometry and Norn's test during therapy with ultra-high viscosity hyaluronic acid. The given clinical examples show the importance of timely diagnosis and treatment of DES.

Conclusions. The study showed the importance of dry eye syndrome evaluation and timely artificial tear therapy prescribing for both to achieve a high postoperative result and to reduce the patients’ subjective discomfort and improve patients’quality of life.
Efficacy of zolmitriptan nasal spray in adult patients with migraine
Authors: Amelin A. V. , Vaganova I. S. , Koreshkina M. I. , Tereshchenko N. M.
Published: August 2023

Introduction. Migraine is a common disabling condition. Migraine patients require fast-acting drugs with high efficacy. Prior studies have demonstrated that zolmitriptan oral dosage forms (oral tablets) are highly effective in the treatment of migraine attacks.

Aim. To evaluate the efficacy, timing of onset of therapeutic effect and tolerability of zolmitriptan nasal spray (Xsenza®) in the treatment of migraine.

Materials and methods. A total of 39 patients aged 20 to 58 years with migraine were enrolled in a prospective, multicentre, observational study. Patients were included in a group to treat three consecutive migraine attacks with zolmitriptan nasal spray at a dose of 2.5 mg according to their habitual behaviour model that most closely reflects clinical practice. Efficacy endpoint (positive attack treatment outcome) was the generally accepted measure of reduction in cephalalgia intensity and concomitant autonomic symptoms (reduction in pain and autonomic symptoms from severe/moderate to mild/absence severity according to VAS) 2 hours after zolmitriptan inhalation.

Results. The absence or mild intensity of headache was reported in 25% of patients 10 minutes (earliest assessment in that study) and in 28% of patients 30 minutes after administration of the drug. The proportion of patients with positive treatment outcomes in all three consecutive migraine attacks two hours after administration of zolmitriptan nasal spray 2.5 mg was 69.2%, 75% and 75%, respectively. Zolmitriptan nasal spray was well tolerated, while most adverse events were mild in severity and transient in nature.

Conclusions. Zolmitriptan nasal spray (Xsenza®) is highly effective in the treatment of migraine attacks and has a rapid onset of action. The drug combines high efficacy and good tolerability.
JUVENILE HORMONE III: SOURCE REACTIONS AND COLLISION-INDUCED DISSOCIATION IN ESI-MS/MS
Authors: Mendonça Jacqueline , Jabor Valquíria , Arini Gabriel , da Silva Ricardo , da Silva Rafael , Vessecchi Ricardo , do Nascimento Fabio , Lopes Norberto
Published: August 2023

Juvenile hormone (JH III) is an important example of a chemical signaling derived from the terpene biosynthetic pathway. Because of its impact on many species’ reproductive and developmental processes, analytical approaches must be developed to accurately identify and measure it in biological samples. In this technical note, we explored the gas-phase dissociative behavior of JH III using tandem mass spectrometry combined with electrospray ionization to provide diagnostic fragment-ions for quantitative purposes.
Mechanism of time-delay feedback control of suspension damping with an annular vibration-absorbing structure
Authors: Chen Yajie , Ma Kehui , Ren Chuanbo , Nan Yang , Zhou Pengcheng
Published: August 2023

With the aim of enhancing both the ride comfort and the safety of the vehicle, we propose a new type of suspension with an annular vibration-absorbing structure, and establish a 3-DOF 1/4 vehicle model. The structure parameters and time-delay feedback control parameters are determined by particle swarm optimization algorithms, which take the root mean values of body acceleration, suspension dynamic deflection, and tire dynamic displacement as their optimization objectives. We analyze the stability of the suspension control system to ensure the stability of the time-delay control system through the Routh-Hurwitz stability criterion, characteristic root method, and stability switching method. Then, we compare and analyze the response characteristics of conventional suspension, new suspension without time-delay feedback control, and new suspension with time-delay feedback control under simple harmonic excitation and random excitation. The results show that the new suspension with time-delay feedback control has a significant damping effect on the body under the premise of ensuring the stability of the system.
Razumikhin approach in the generalized Myshkis problem for systems with distributed delay
Authors:   St. Petersburg State University, Egorov Alexey V.
Published: August 2023

The paper gives sufficient conditions for the solvability of the generalized Myshkis problem for a system of equations with a distributed time-varying delay and a constant kernel. Conditions on the kernel which guarantee the uniform stability of the system for any admissible delay are obtained. The admissible delay in this paper is a piecewise continuous function bounded from above in magnitude and growth rate. The applicability of the obtained conditions is illustrated by two examples.
Identification of low and medium intensity gas leakage location in medium and ultra-high pressure gas pipelines
Authors:   St. Petersburg State University, Kurbatova Galina I. , Klemeshev Vladimir A. ,   St. Petersburg State University
Published: August 2023

An efficient method for calculating the location of stationary gas leakage in wells and gas pipelines with medium and ultra-high pressures is presented. An algorithm for constructing the dependence of the compressibility factor of the gas mixture with a predominance of methane in the region of ultra-high pressures based on experimental data of pressure and temperature is proposed. The algorithm for calculating the leakage location is based on the Bellman method of quasi-linearization of nonlinear problems, with an additional hypothesis of the linear dependence of pressure and temperature on the leakage location coordinates used at each iteration. The issue of selecting the initial approximation is considered, and the advantage of calculating the initial approximation using a simplified non-isothermal flow model is justified. Examples of solving practical problems of high interest are given, and the high accuracy of calculating the gas leakage location using the proposed algorithm in gas pipelines with medium pressures (around 9 MPa) and ultra-high pressures (around 20 MPa) for small and medium gas leaks is demonstrated.
Control and perturbation in Sturm — Liouville’s problem with discontinuous nonlinearity
Authors:   St. Petersburg State University, Baskov Oleg V. , Potapov Dmitriy K. ,   St. Petersburg State University
Published: August 2023

We consider the Sturm — Liouville problem with discontinuous nonlinearity, control and perturbation. Previously obtained results for equations with a spectral parameter and a discontinuous operator are applied to this problem. By the variational method, we have established theorems on the existence of solutions to the Sturm — Liouville problem with discontinuous nonlinearity and to the optimal control problem, as well as on topological properties of the set of the acceptable “control — state” pairs. A one-dimensional analog of the Gol’dshtik model for separated flows of an incompressible fluid with control and perturbation is given as an application.
Colour as Symbols in the Select Works of Yann Martel
Authors:   Department of English, Annamalai University, Chidambaram. Tamil Nadu, Darwin M. Arul , Anand Arul
Published: August 2023

Colours can draw an identity to all living things. Natural colours can either calm down or disturb a person’s inner Self. At the times of crisis, it tends to give the individual soul wit and hope. Colours also have alchemical significance and can impact every man’s mind in certain ways. Colour representations have been used by many symbolists throughout literary history from the past to the present. Symbolists point out the importance of symbols in the poems of symbolist poetry. Moreover, the use of colour symbolism in literature contributes to the treasure of literary forms. In Canadian literature, Yann Martel holds a prominent position for his adaption of symbols and uses them to portray the inner quest of his characters. Frequently, his symbolism embodies a deep search for a spiritual quest with a religious component. Colour is one of the most important aspects in deciphering the psyche of his heroes. He has constructed various symbolic interpretations that exhibit the spiritual longing of individuals. Many colours like red, black, white, green, orange, etc have been used as symbolic representations to decode the mind set and religious beliefs. Among them, black and white colours play a vital role in an in-depth portrayal of the leading characters. The religious quest of the characters has been satisfied through the identification of colour representations and ancient relics. They were satisfied at the end. Hence, his works depict that colours have symbolic dramatic elements that naturally novelize the central theme of the search for Self. It also emphasizes the development of the Self with the supremacy of faith in the Almighty God. This paper deciphers the black and white colour symbols in the novels, “Self”, “Life of Pi”, “Beatrice and Virgil”, and “The High Mountains of Portugal” of Yann Martel.
Fog water harvesting potential and its use in supplementary irrigation of rainfed crops (winter wheat) in Abi-beyglu, Ardabil (Iran)
Authors: Kanooni Amin , Kohan Mohammad Reza
Published: August 2023

In arid and semi-arid areas where available water resources are very limited, the application of unconventional sources of water like the fog is of paramount importance. In this paper, the feasibility of using a standard fog collector (SFC) to collect fog water for complementary irrigation of rainfed wheat in the Abi-beyglu area was investigated. For this purpose, collected water volume was measured on a daily basis during fog time in 2021. The water demand of the winter wheat was estimated by the FAO Penman–Monteith equation under dry and normal conditions. Then the contribution of the collected water to supply the water demand of the wheat and the resultant increase in the yield under two different scenarios, namely complementary irrigation with 30 and 60 mm of collected water, was estimated using the AquaCrop model. Results showed that it is feasible to obtain an average water production of 3.6 L/m2/day over the studied period. Upon irrigation with 30 and 60 mm of collected water under dry and normal conditions, 26 and 34% of the water deficiency for wheat farming was supplied, leading to increased crop yields by 0.6 and 1.7 ton/ha, respectively.
La experiencia del cuidado humanizado en personas hospitalizadas: un estudio transversal
Authors: Lobo-Osorio Diana , Oviedo-Córdoba Haidy , Cortina-Navarro Carolina
Published: August 2023

Introducción: en la actualidad es común encontrar avances científicos que traen esperanza, motivación y oportunidad. Al mismo tiempo, están limitadas por el enfoque biomédico de la formación y el cuidado, que reduce lo humano a lo natural y procedimental, así como el cuidado a la enfermedad, y conduce a la deshumanización del cuidado. Objetivo: falta. Método: un estudio descriptivo fue realizado con personas hospitalizadas. Los participantes completaron el instrumento Percepción del Cuidado Humanizado proporcionado por la profesión de enfermería. Resultados: Participaron 148 personas; El 44% siempre percibió el cuidado humanizado, el 25% casi siempre, el 14% regularmente, el 6% pocas veces y el 9% nunca percibió el cuidado humanizado. Conclusiones: se destaca la categoría de cualidades del trabajo del enfermero con la generación de sentimientos, confianza y bienestar, así como la voluntad de cuidar, y la preocupación por las necesidades de la persona, seguido del trato digno percibido por la escucha activa, presencia y compresión.
Ensayo de biocompatibilidad con Artemia salina para cinco materiales de uso endodóntico
Authors: Torres-Avirama Leidy Johanna , Realpe-Urbano Daniela Alexandra , Guevara-Valencia Tania Lizeth , Morales Gilbert Alfonso , Zamora-Córdoba Ingrid Ximena , Valencia-Llano Carlos Humberto
Published: August 2023

Introducción: la biocompatibilidad es un factor decisivo para el éxito de una terapia endodoncica. Objetivo: evaluar la citotoxicidad de cinco materiales de uso endodóntico mediante la prueba de Artemia Salina. Método: se diseñó un estudio experimental in vitro, empleando Artemia salina, para evaluar la biocompatibilidad de los cementos Grossman, CaOH, AH-Plus, MTA y TheraCal-LC con observaciones a 24 y 48 horas. Resultados: los resultados indican que el cemento Grossman presenta un 100% de toxicidad a las 24 horas, mientras que los demás materiales muestran valores menores al 30%, reflejando un comportamiento biocompatible, sin embargo, a las 48 horas, CaOH y TheraCal-LC presentan una toxicidad mayor al 30%, mientras que AH-Plus y MTA continúan con valores -menores del 30%. Los datos fueron analizados con un Modelo lineal generalizado con distribución de errores binomial, un análisis de devianza, y la prueba de comparación múltiple de Fisher con corrección Bonferroni.  Se hizo un análisis independiente para las 24 y 48 horas, bajo un nivel de significancia α=5%, se encontraron diferencias significativas a las 48 horas entre TheraCal-LC y AH-Plus y MTA. Conclusión: se concluye que el cemento Grossman presentó un alto grado de toxicidad, mientras que AH-Plus y MTA mostraron la mayor biocompatibilidad
Bajo peso al nacer en Colombia según condiciones socioeconómicas de la madre
Authors: Mestre-Mestre Mauricio Andrés , Escobar-Velásquez Katty Dayana
Published: August 2023

Introducción: los recién nacidos con bajo peso al nacer (BPN) tienen 20 a 40 veces más probabilidad de morir que recién nacido con peso normal. El objetivo del estudio fue establecer las características socioeconómicas de las madres asociadas al BPN en Colombia según los datos de la Encuesta Nacional de Demografía y Salud. Métodos: Se realizó análisis secundario de la ENDS 2015. Se calcularon las asociaciones entre las características socioeconómica de la madre y el BPN. Resultados: la distribución por género, mostró un predominio del sexo femenino, presentando una prevalencia de BPN mayor que el masculino (9.50% vs 8.29%).Se observó diferencias significativa en las prevalencias de BPN por edad  (p- valor  0.002) con mayor prevalencia de la condición en madres en edades extremas (OR 1,29 IC 95% 1,10 -1,51 ) y nivel educativo de la madre( OR 1,11 IC 95%  0,949445- 1,306799 ), Conclusión: se concluye que  el BPN es más probable en recién nacidos femeninas de madres cuyas edades sean menores de 20 años o mayores de 40 años con nivel educativo inferior al pregrado. Se recomienda identificar tendencias en el comportamiento del BPN contratando estos resultados con la próxima versión de ENSIN.
Sepsis: las dos caras de la moneda
Authors: Villalba-Vizcaíno Vivian Tatiana
Published: August 2023

El término sepsis deriva del griego ‘sipsis’ que significa putrefacción o decadencia de la materia orgánica. Como término médico, el concepto de sepsis ha estado en constante cambio. La definición actual derivada del Tercer Consenso Internacional de definiciones de sepsis del año 2016 considera como una disfunción de órganos que amenaza la vida, causada por una desregulación de la respuesta del hospedador a una infección
Potencial Risco de Contaminação do Sistema Aquífero Dunas-Barreiras por Atividades Antrópicas em Área de Manancial no Nordeste Brasileiro
Authors: Bezerra Allison , Lopes Vera , Di Lollo José Augusto , Lorandi Reinaldo , Costa Carlos
Published: August 2023

A busca por recursos hídricos sempre foi um critério de desenvolvimento humano. No entanto, os impactos negativos deflagrados por atividades antrópicas demonstram a importância da conservação dos mananciais. A partir de uma Análise Multicritério, envolvendo álgebra de mapas e Combinação Linear Ponderada de atributos do meio físico, biótico e antrópico, em ambiente de Sistemas de Informação Geográfica (SIG), o presente trabalho se propõe a identificar, em escala 1:100.000, áreas com maiores potenciais riscos de contaminação das águas subterrâneas no sistema Aquífero Dunas-Barreiras, na área do Sistema Bonfim. Tal manancial está localizado na região NE do Brasil, próximo ao litoral oriental do Rio Grande do Norte, sendo utilizado para o abastecimento de cerca de 300.000 pessoas. Os resultados apontam que 46,14% da área do manancial apresentou potenciais de contaminação Médio, Forte e Muito Forte. Por outro lado, áreas com potencial Desprezível abrangeram 39,73% representadas por áreas seminaturais, sem a presença de atividades antrópicas. A espacialização do potencial risco à contaminação das águas subterrâneas desse manancial visa auxiliar tomadas de decisão, pública e privada, contribuindo para o planejamento territorial dos municípios de São José de Mipibu e Nísia Floresta, apresentando áreas em que uso antrópico deveria ser retardado, priorizando a conservação
School Gardens in Poland – Rediscovered Places
Authors: Ziemkowska Joanna
Published: August 2023

School gardens have been present in the educational space of the Polish school for many years. In recent decades, however, they have ceased to be appreciated. Efforts have been made to modernize laboratories, they have been equipped with measuring instruments, digital devices and multimedia equipment. A natural laboratory, which a garden in fact is, has become a symbol of the past. It remained only in few schools, performing rather an aesthetic function, less often didactic or educational one. The present article depicts a historical outline, shows earlier and currently noticed possibilities of using school gardens in Poland. An analysis of previous studies on gardens is presented as well. A contemporary design of a school garden was proposed to prepare students of pedagogical faculties for activities in the garden with children. School gardens may contribute to the prevention of “nature deficit” (Louv 2014, 54), they may give a sense of closeness to nature also in urban realities[1]. M. Vogt-Kostecka notes that the fear of dirt, wind and ticks limits children's free play in a meadow and in a forest. Limited access to nature is particularly visible among urban children (Vogt-Kostecka 2017, 11). Gradually, the view of school gardens has been changing and their therapeutic potential (hortitherapy) is noticed.
 
[1] According to R. Louv, the nature deficit is manifested in problems with concentration of attention, hyperactivity, and reduced psychophysical fitness.
demandas por reconhecimento em Jurgen Habermas e Axel Honneth
Authors: Feldhaus Charles , Saraiva Juliana Marques
Published: August 2023

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Anticancer Effect of Dihydroartemisinin via Dual Control of ROS-induced
Apoptosis and Protective Autophagy in Prostate Cancer 22Rv1 Cells
Authors: Yang Jiaxin , Xia Tong , Zhou Sijie , Liu Sihao , Pan Tingyu , Li Ying , Luo Ziguo
Published: August 2023

Background:

Dihydroartemisinin (DHA), a natural agent, exhibits potent anticancer
activity. However, its biological activity on prostate cancer (PCa) 22Rv1 cells has not been previously
investigated.

Objective:

In this study, we demonstrate that DHA induces anticancer effects through the induction
of apoptosis and autophagy.

Methods:

Cell viability and proliferation rate were assessed using the CCK-8 assay and cell clone
formation assay. The generation of reactive oxygen species (ROS) was detected by flow cytometry.
The molecular mechanism of DHA-induced apoptosis and autophagy was examined using
Western blot and RT-qPCR. The formation of autophagosomes and the changes in autophagy flux
were observed using transmission electron microscopy (TEM) and confocal microscopy. The effect
of DHA combined with Chloroquine (CQ) was assessed using the EdU assay and flow cytometry.
The expressions of ROS/AMPK/mTOR-related proteins were detected using Western blot.
The interaction between Beclin-1 and Bcl-2 was examined using Co-IP.

Results:

DHA inhibited 22Rv1 cell proliferation and induced apoptosis. DHA exerted its antiprostate
cancer effects by increasing ROS levels. DHA promoted autophagy progression in 22Rv1
cells. Inhibition of autophagy enhanced the pro-apoptotic effect of DHA. DHA-induced autophagy
initiation depended on the ROS/AMPK/mTOR pathway. After DHA treatment, the impact of Beclin-
1 on Bcl-2 was weakened, and its binding with Vps34 was enhanced.

Conclusion:

DHA induces apoptosis and autophagy in 22Rv1 cells. The underlying mechanism
may involve the regulation of ROS/AMPK/mTOR signaling pathways and the interaction between
Beclin-1 and Bcl-2 proteins. Additionally, the combination of DHA and CQ may enhance the efficacy
of DHA in inhibiting tumor cell activity.
Male Breast Cancer: Three Case Reports and a Literature Review
Authors: Xin Yuanfang , Wang Fengmei , Ren Dengfeng , Zhao Fuxing , Zhao Jiuda
Published: August 2023

Introduction:

Male breast cancer (MBC) accounts for 0.5%-1% of all breast cancers diagnosed worldwide.
However, its biological characteristics can be distinguished from that of female breast cancer (FBC)

Case Representation:

The diagnostic and treatment approaches for MBC are mainly similar to that of FBC due to the
lack of male breast cancer-related studies, clinical trials, and literature. An increasing number of retrospective and
prospective studies have been conducted to clarify the individualized care for MBC. Herein, we report three cases of
advanced MBC to describe the diagnostic approaches, treatment process, and survival prognosis.

Conclusion:

MBC patients had older age, later stage at first diagnosis, higher expression of hormone receptors, and
poor prognosis. A literature review was conducted to determine the incidence, risk factors, disease features, diagnosis,
treatment, survival, and management of MBC.
Therapeutic and Phytochemical Properties of Thymoquinone Derived
from Nigella sativa
Authors: Tiwari Gaurav , Gupta Monisha , Devhare Lalchand D. , Tiwari Ruchi
Published: August 2023

Background:

Nigella sativa (N. sativa), commonly known as black seed or black cumin,
belongs to the family Ranunculaceae. It contains several phytoconstituents, Thymoquinone
(TQ), thymol, thymohydroquinone, carvacrol, and dithymoquinone. TQ is the main phytoconstituent
present in N. sativa that is used as an herbal compound, and it is widely used as an antihypertensive,
liver tonic, diuretic, digestive, anti-diarrheal, appetite stimulant, analgesic, and antibacterial
agent, and in skin disorders.

Objective:

The study focused on collecting data on the therapeutic or pharmacological activities of
TQ present in N. sativa seed.

Methods:

Antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory,
hepato-protective, renal protective, and antioxidant properties of TQ have been studied by various
scientists.

Conclusion:

TQ seems to have a variety of consequences on how infected cells behave at the cellular
level.
Deep Learning: History and Evolution
Authors: Suraj Lachure Jaykumar , Verma Gyanendra , Doriya Rajesh
Published: August 2023

Recently, deep learning (DL) computing has become more popular in the
machine learning (ML) community. In the field of ML, the most widely used
computational approach is DL. It can solve many complex problems, cognitive tasks,
and matching problems without any human performance or interface. ML cannot
handle large amounts of data and DL can easily handle it. In the last few years, the field
of DL has witnessed success in a range of applications. DL outperformed in many
application domains, e.g., robotics, bioinformatics, agriculture, cybersecurity, natural
language processing (NLP), medical information processing, etc. Despite various
reviews on the state of the art in DL, they all concentrated on a single aspect of it,
resulting in a general lack of understanding. There is a need to provide a better
beginning point for comprehending DL. This paper aims to provide a more
comprehensive overview of DL, including current advancements. This paper discusses
the importance of DL and introduces DL approaches and networks. It then explains
convolutional neural networks (CNNs), the most widely used DL network type and
subsequent evolved model starting with LeNET, AlexNet with the Letnet-5, AlexNet,
GoogleNet, and ResNet networks, and ending with the High-Resolution network. This
paper also discusses the difficulties and solutions to help researchers recognize research
gaps for DL applications.
Risk–based Approach to Air Quality Management
Authors: Bontos Marius D.
Published: August 2023

In the last decades, increased air pollution has been the world's largest
environmental health threat, and new causal relationships between it and human
diseases have been discovered. To better understand the relationship between air
pollution and health risks and to promote the most efficient measures that may reduce
the health impact, the chapter sets the context regarding the risk–based approach to air
quality management and presents the Health Impact Assessment of Air Pollution, the
Health Risk Assessment process and the tools that can be used for assessing it. To
support the theoretical information described, several case studies were presented.
Risk-based Approach for Safe Drinking Water
Authors: Robescu Lacramioara D.
Published: August 2023

The United Nations (UN) recognizes access to safe drinking water as a
fundamental human right. However, there are still many people without access to safe
drinking water, and diseases caused by contaminated water pose a serious threat to
human health. By 2030, progress would need to be made at four times the current rate
to achieve UN Sustainable Development Goals related to water. The drinking water
system has several points where undesired events could happen, allowing contaminated
water to be delivered to the public. The safety and quality of the drinking water that
they provide are always the suppliers' responsibility. Risk management is a crucial
component in ensuring the supply of safe drinking water. One strategy for supplying
consumers with safe drinking water is the “multiple barrier approach”. Risk-based
methodologies are more effective to identify and manage the hazards in the drinking
water system to provide a consistent supply of safe drinking water. To encourage the
development and use of risk management methods, the World Health Organization
(WHO) has created guidelines for the quality of drinking water. European Drinking
Water Directive that was revised and entered into force, which started in January 2021,
also includes a risk management system for the “source-to-tap”. This chapter presents
aspects concerning water contamination and health, an overview of drinking water
supply systems, safe drinking water risk management strategies, and the framework for
safe drinking water to focus on water safety plan development.
Characteristics of patients with decompression illness at the hyperbaric polyclinic of Prof IGNG Ngoerah General Hospital Bali before the COVID-19 pandemic
Authors: Indah Carolin Tiara Lestari , Arimbawa I Komang , Widyantara I Wayan , Laksmidewi Agung Ayu Putri , Putra Ida Bagus Kusuma , Devi Anita
Published: August 2023

Decompression illness (DCI) is an injury suffered by divers due to the formation of nitrogen bubbles in the bloodstream and tissues during or after a pressure drop in the surrounding environment when diving. Bali is one of the most famous diving spots in Southeast Asia and also has a Hyperbaric Oxygen Therapy (HBOT) center in Prof. IGNG Ngoerah General Hospital. This study aims to determine the characteristic of DCI patients at the Hyperbaric Polyclinic in Prof. IGNG Ngoerah General Hospital, Denpasar, Bali before the COVID-19 pandemic. A descriptive retrospective study has conducted by descriptive retrospective by collecting administrative data at the Hyperbaric Polyclinic of Prof. IGNG Ngoerah General Hospital in 2018-2019. The required examination data are demographic data, diver profiles, DCI characteristics, and the previous therapy. Data analysis using SPSS Version 24. Most DCI patients in this study were foreigner (88.1%), men (53.2%), normal BMI (37.3%), no prior history of disease (88.9%), diving depth  >20 meters (n=79, 62.7%), average surface interval 101,184 minutes (30-1440 minutes), diving duration 1-3 hours (n=69.54.8%), DCI type 2 (58.7%) with major severity (57.9%). Of the overall patients, 14.3% rapid ascent, 2.4% panicked while diving, 10.3% made flights and 6.3% climbed after diving.
The Influence of Early Life Experiences on Later Life Behaviors: An Examination of the Life of Walt Disney
Authors: Deem Jack , Starnes David , Ziegler James
Published: August 2023

In this paper we tell the story of Walt Disney, synthesizing the concepts of critical biography with those of life-span theory (LST) from sociology and psychology literature. In this manner, we can better understand how events in one’s life can have a significant impact throughout that person’s life. The paper focuses on four themes: (a) work ethic and pursuit of success, (b) perseverance – bounce back from adversity and keep moving forward, (c) alliance with others who complement one’s own strengths and offset one’s weaknesses, and (d) commitment to excellence. Through these themes, we demonstrate how early life experiences influenced Walt Disney’s behavior throughout his life. Table 1 is provided to outline the key events in the life of Walt Disney, cross-referencing the events as reported within the major Walt Disney biographies.
Konferencja o ochronie obszarów wodno- -błotnych w Polsce z okazji Światowego Dnia Mokradeł (4–7 luty 2023, Warszawa)
Authors: Kapler Adam
Published: August 2023

Mokradła były osuszane przez tysiąclecia. Od ponad wieku wiele z nich chroni się jednak jako rezerwaty, parki narodowe i/lub tereny Natura 2000. Większość bagien Polski uległa jednak degradacji, toteż warto pomyśleć o ich odtworzeniu. Jest to problem szalenie trudny do rozwiązania, szczególnie w dobie wojny w Ukrainie, rosnącej polaryzacji społecznej wokół NRL [2022], kryzysu humanitarnego na granicy polsko-białoruskiej oraz klęki ekologicznej w Odrze. Dlatego Światowy Dzień Mokradeł 2023, obchodzony corocznie z inicjatywy Centrum Ochrony Mokradeł, w rocznicę podpisania Konwencji z Ramsar, miał w tym roku szczególnie rozbudowany program. Prócz wygłaszanych corocznie debat, wykładów otwartych, prezentacji posterów i wycieczek terenowych w lutym 2023 r. zorganizowano dodatkowo: ściśle naukową, parodniową konferencję o ochronie obszarów wodno-błotnych, dwie wycieczki terenowe tudzież szereg warsztatów dla praktyków. Słowa kluczowe: Światowy Dzień Mokradeł 2023, Konwencja Ramsarska, bagna, zmiany klimatu
Biocontrol de Fusarium spp. en el cultivo de vainilla: Un nuevo modelo de estudio
Authors: Franco-Galindo Laura Steffania , Mosquera-Espinosa Ana Teresa
Published: August 2023

Biological control is a potential and sustainable option to deal with crop production and yield problems affected by insects or pathogenic microorganisms. In vanilla crop, obtaining the natural scent present in its fruits is limited, mainly by diseases that affect commercial crops. The main disease of vanilla crop is root and stem rot (RSR), caused by F. oxysporum f. sp. radicis-vanillae and F. oxysporum f. sp. vanillae. We found that the use of endophytic fungi (EF) isolated from healthy or asymptomatic plants requires systematic research for the selection of the most effective species to control pathogens, particularly in this crop. Additionally, there is no evidence reported with respect to this topic, in spite of, the use of these microorganisms is a natural alternative in other crops, compared to the use of agrochemicals used in traditional agriculture. This review addresses the perspective, and raises the need for research on the potential use of endophytic fungi as biological control agents of fungal pathogens in cultivated plants, emphasizing the relationship Endophytic fungi-Vanilla-pathogenic Fusarium.
Prospective Analysis of Aluminum Metal for Energy Applications
Authors: Chen Jianru
Published: August 2023

With the increasing global demand for sustainable energy, metal aluminum has shown tremendous potential and advantages as an important energy material. This article focuses on exploring the application prospects of metal aluminum in renewable energy, energy storage, and energy efficiency. In the field of renewable energy, metal aluminum can be used in the manufacturing of solar cell components and auxiliary equipment. Its properties make it a suitable material for these applications. In terms of energy storage, metal aluminum exhibits high performance and a long lifespan in hydrogen storage and energy storage devices. It shows promise as an efficient and durable choice for these applications. In the field of energy efficiency, metal aluminum plays a significant role as a lightweight material in the automotive industry and in thermal management technologies. It can contribute to improving energy utilization efficiency and reducing energy consumption in various applications. However, the application of metal aluminum still faces some challenges, including cost and sustainability issues. Therefore, further research, development, and collaboration are needed to promote the application and development of metal aluminum in the energy sector, contributing to the achievement of sustainable energy goals.
Smelling Caddy: Olfactory Narrative in the Sound and the Fury
Authors: Wang Yiren.
Published: August 2023

The Sound and the Fury, a long stream-of-consciousness novel written by American writer William Faulkner, mainly depicts a girl’s gradual degradation. This degradation emblems the decline of the Compson family and the collapse of the old moral order of southern American society in the first half of the twentieth century. This paper aims to analyze the olfactory narrative from the perspective of unnatural narratology. Firstly, it interprets the cultural symbolic meanings of the most representative odors in Caddy’s two different stages by employing unnatural narratology theory. Secondly, it explores the role of the olfactory narrative in the creation of Caddy’s image throughout this novel. This paper argues that the olfactory narrative endows Caddy with implicit cultural implications, pushes the plot of Caddy’s destiny forward, and enhances the narrative effect of this novel.
Teaching Design of Senior High School English Writing Based on Pragmatics Theory
Authors: Lei Wenjing , Lei Kun
Published: August 2023

This paper first overviews the pragmatic theory and mainly introduces Grice’s Conversational Cooperative Principle and Leech’s Politeness Principle. Then, the application situations of the Cooperative Principle and Politeness Principle in English teaching at home and abroad are reviewed. Finally, through analyzing the relevance of the Cooperative Principle, Politeness Principle and English writing teaching in senior high school, taking Unit 1 “Teenage Life”, the first volume of compulsory English for senior high school in the People’s Education Press (2019 edition), as an example, this paper presents a reading and writing teaching design that integrates pragmatics theory with English writing teaching in senior high school.
Research on the Applicability of Value Investment in China’s A-Share Market
Authors: Dan Luo
Published: August 2023

Value investment has been widely respected and applied in the capital market of developed countries, and its effectiveness has also been verified in a large number of practices. However, since it was introduced to China in 1990s, the concept of value investment has been buried for a long time due to the lack of supervision and the backwardness of investment concepts. With the improvement of the market environment, the progress of supervision system and the update of investors’ ideas in recent years, does China’s A-share market have the conditions for value investment? This paper will discuss this problem theoretically and empirically. Firstly, this paper combs the development of value investment theory and expounds the views and propositions of value investment. Secondly, under the guidance of value investment theory, this paper selects the data of CASMR database 2018-2021. In the first stage, five sectors are selected as the low growth and high growth track of value investment by using multi-factor model. In the second stage, using EVA analysis, five leading stocks in each industry are selected for empirical test, combined with the fundamental analysis in each stage. The results show that the average annual rate of return of the top enterprises is over 50% and the average annual rate of return is over 30% in the high-growth industries screened out under the concept of value investment; This paper verifies that value investment is not only suitable for China A-share market, but also an excellent investment idea with low risk and high return, and puts forward some relevant investment suggestions.