bluuebunny/crossref_metadata_2025 huggingface dataset:
Depression-like Behavior and Alterations of Neurotransmitters and the Corresponding Receptors in the Triple Transgenic Mouse Model of Alzheimer's Disease
Authors: Zhang Meng , Liu Li-yuan , Xu Yong , Wang Wen-zhi , Qiu Nian-zhuang , Zhang Fang-fang , Zhang Feng , Wang Xiao-dan , Chen Wei , Xu Xiao-yan , Gao Yong-feng , wang hao , Li Yu-qin , Chen Mei-hua , Zhang Han-ting
Published: December 2022

Backgrounds: Depression is among the most frequent psychiatric comorbid conditions in Alzheimer’s disease (AD). However, pharmacotherapy for depressive disorders in AD is still a big challenge；current antidepressants used clinically, such as monoamine antidepressants, have shown only modest or little clinical benefits. Here we investigated the mechanism of the interactions between depression and AD, which we believe would aid in the development of pharmacological therapeutics for the comorbidity of depression and AD.
Methods: Female APP/PS1/Tau triple transgenic (3×Tg-AD) mice at 20 months of age and age- and gender-matched wild-type (WT) mice were used. The shuttle-box passive avoidance test (PAT), the open field test (OFT), and the tail suspension test (TST) were implemented to assess behavioral changes. High-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) was used to detect the level of neurotransmitters related to depression in the hippocampus of mice. The data was identified by orthogonal projections to latent structures discriminant analysis (OPLS-DA). The expression of relative receptors was detected using Western blot.
Results: Compared to WT, 3×Tg-AD mice displayed significant cognitive impairment in the PAT and depression-like behavior in the OFT and TST. They also showed significant decreases in the levels of L-tyrosine, norepinephrine, vanillylmandelic acid, 5-hydroxytryptamine, and acetylcholine, in contrast to significant increases in 5-hydroxyindoleacetic acid, L-histidine, L-glutamine, and L-arginine in the hippocampus. The expression of the alpha 1a adrenergic receptor (ADRA1A), serotonin 1A receptor (5HT1A), and γ-aminobutyric acid A receptor subunit alpha-2 (GABRA2) was significantly downregulated in the hippocampus of 3×Tg-AD mice, while histamine H3 receptor (H3R) expression was significantly upregulated. In addition, the ratio of phosphorylated cAMP-response element-binding protein (pCREB) and CREB was significantly decreased in the hippocampus relative to WT.
Conclusions: We demonstrated in the present study that aged female 3×Tg-AD mice showed depression-like behavior accompanied with cognitive dysfunction. The complex and diverse mechanism appears not only relevant to the imbalance of multiple neurotransmitter pathways, including the transmitters and receptors of the monoaminergic, GABAergic, histaminergic, and cholinergic systems, but also related to the changes in L-arginine and CREB signaling molecules.
Vertebral Artery Stenting for Acute Multiple Cerebral Infarctions Caused by Vertebral Artery Dissection After Massage: A Case Report
Authors: Cui Yingxue , Hou Xuesi , Liu Guilin , Ji Xu , Li Bin , Wang Shaosong
Published: December 2022

Background: Vertebral artery dissection (VAD) is a special cause of ischaemic stroke in young patients. Cervical vertebrae massage, especially improper pulling manipulation, is one cause of vertebral artery dissection. The best therapy for acute VAD, whether conservative antithrombotic therapy or emergency endovascular therapy, has always been a topic of discussion.
Case presentation: The case of a young woman with acute multiple posterior circulation ischaemic cerebral infarction caused by left vertebral artery V4 segment dissection after improper neck massage is reported. Due to the serious condition of the patient, we performed emergency vertebral artery stent implantation at the site of dissection. The symptoms of the patient were significantly relieved on the second day. She recovered well in the later period without adverse complications or intravascular restenosis in the following year.
Conclusions: Endovasculartherapy may be an effective measure to quickly relieve clinical symptoms and reduce serious complications in patients with acute VAD. Additional clinical observations are needed.
Crosslinking modification of polyamide composite membranes toward high performance for DMAc/H2O dehydration
Authors: Ma Wenzhong , Wei Ziang , Zhong Jing , Jiang Chao , Song Xiangyuan , Yuan Guorui , Cheng Zaiqi , Ma Binghao , Matsuyama Hideto
Published: December 2022

Polar aprotic solvents such as dimethylacetamide (DMAc) play a crucial role in the chemical industry. Pervaporation is a membrane separation technology suitable for the dehydration of organic solvents. In this study, thin polyamide (PA) pervaporation membranes with different structures were prepared by interfacial polymerization using trimesoyl chloride (TMC) as the organic phase, and either m-phenylenediamine (MPDA), propylene diamine (DAPE), or tetraethylene pentamine (TEPA) as the aqueous phase. In addition, the PA pervaporation membranes' chemical composition, hydrophilicity, surface morphology, and cross-sectional morphology were examined by fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), atomic force microscopic (AFM) and contact angle (CA) analysis, respectively. The results showed that the PA pervaporation membrane prepared with TEPA as the aqueous monomer exhibited a high degree of crosslinking, resulting in dense molecular chains. The permeation flux and water content of 10 wt % DMAc/H2O system were 17.8 L m− 2 h− 1 and 98.4 wt % at 500 Pa and 70 ° C, respectively. Therefore, the TEPA-PA membrane has a good separation performance even when dealing with a low-concentration DMAc/H2O system.
production of chitosan from Rhizopus stolonifer by submerged fermentation in Sweet Sorghum Juice
Authors: alazmeh mohammad fawaz , issa nizar
Published: December 2022

Background

Due to important, multiple uses of chitosan and lake of its traditional sources (crustacean shells) in Syria ,it was necessary to extract chitosan from alternative sources like fungal cell wall considering that fungal mycelium can be obtained by simple ,rapid ,and low cost ways regardless of geographical location or season, In recent years, there have been a number of statistics around the world for vegan and vegetarian populations. There are about 5 out of 100 persons getting affected by crustacean allergy, which means that about 300 million persons need non-crustacean-ingredients. This is the reason that people are getting interested in replacing the animal source products with non-animal source products.

Results

In this study chitosan was extracted from Rhizopus stolonifer by submerged fermentation in Sweet Sorghum Juice. It was observed after growing fungus on diluted Sweet Sorghum Juice by submerged fermentation that the biggest amount of chitosan extracted from Rhizopus stolonifer was 0.256 g (4.9% of mycelium dry weight). The liquid medium was optimized to get the biggest dry weight of this fungus. The results showed that diluting the fermentation medium to 30/70 v/v in distilled water under submerged fermentation for 6 days at 25º C degree by adding 2% of peptone had given the biggest dry weight of Rhizopus stolonifer.

Conclusion

Further studies are needed to examine and improve extracted amount of chitosan from different species of fungi.
Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis
Authors: Liu Ruijiao , Duan Tengfei , Yu Li , Tang Yongzhong , Liu Shikun , Wang Chunjiang , Fang Weijin
Published: December 2022

Background
Increased acid sphingomyelinase (ASMase) activity is associated with insulin resistance and cardiac dysfunction. However, the effects of ASMase on diabetic cardiomyopathy (DCM) and the molecular mechanism(s) underlying remain to be elucidated. We here investigated whether ASMase caused DCM through NADPH oxidase 4-mediated apoptosis.
Methods and Results
We used pharmacological and genetic approaches coupled with study of murine and cell line samples to reveal the mechanisms initiated by ASMase in diabetic hearts. The protein expression and activity of ASMase were upregulated, meanwhile ceramide accumulation was increased in the myocardium of HFD mice. Inhibition of ASMase with imipramine (20mg·Kg− 1·d− 1) or siRNA reduced cardiomyocyte apoptosis, fibrosis, and mitigated cardiac hypertrophy and cardiac dysfunction in HFD mice. The similar effects were observed in cardiomyocytes treated with high glucose (HG, 30 mmol·L− 1) + palmitic acid (PA, 100µmol·L− 1) or C16 ceramide (CER, 20 µmol·L− 1). Interestingly, the cardioprotective effect of ASMase inhibition was not accompanied by reduced ceramide accumulation, indicating a ceramide-independent manner. The mechanism may involve activated NADPH oxidase 4 (NOX4), increased ROS generation and triggered apoptosis. Suppression of NOX4 with apocynin prevented HG + PA and CER incubation induced Nppb and Myh7 pro-hypertrophic gene expression, ROS production and apoptosis in H9c2 cells. Furthermore, cardiomyocyte-specific ASMase knockout (ASMaseMyh6KO) restored HFD-induced cardiac dysfunction, remodeling, and apoptosis, whereas NOX4 protein expression was downregulated.
Conclusions
These results demonstrated that HFD-mediated activation of cardiomyocyte ASMase could increase NOX4 expression, which may stimulate oxidative stress, apoptosis, and then cause metabolic cardiomyopathy.
Motivation of patients with chronic cancer during COVID-19: A qualitative analysis
Authors: Georgescu Irène , Minvielle Etienne , Scotté Florian
Published: December 2022

Purpose
Motivation to treat cancer and prevent its negative impact has been largely explored in a non-pandemic context. However, little is known about the motivation to comply with the treatment, especially during a pandemic. To fill this gap we have explored the individual and contextual factors impacting patients’ motivation during the COVID-19 period using the integrated model.
Methods
We have conducted two qualitative studies before (study 1) and during the COVID-19 (study 2) period in a cancer centre. We respectively interviewed 30 and 22 patients with various chronic cancers in study 1 and also with COVID-19 in study 2. Data analysis was based on content analysis and grounded theory approach identifying the factors affecting patient motivations during both periods, and then comparing them.
Results
Our results show the mechanisms that allow patients to maintain their motivation despite the threats related to COVID-19. They underline the importance of respecting the rules and laws for patients’ motivation.
Conclusion
Compliance with legislation fuels the psychological need of protection in patients, which is a key determinant of motivation in the context of the pandemic. Considering patients’ self-regulatory activities to assess motivational factors, going beyond clinical aspects, to include organisational and quality-of-life-related aspects throughout their care pathway is crucial.
Nanoformulation, Chracterization and In vivo Pharmacokinetic Studies of Diosgenin and Emodin-loaded Polymeric Nanoparticles
Authors: Sherekar Prasad , Suke Sanvidhan , Dani Ragini , Mangrulkar Shubhada , Dhok Archana
Published: December 2022

Obstruct pharmacokinetics and low bioavailability of diosgenin (DG) and emodin (ED) are major limitations for their therapeutic success in several inflammatory diseases. Nanoencapsulation of both drugs will promisingly overcome these limitations. Herein, polylactic-co-glycolic acid (PLGA) was used for nanoformulation of diosgenin and emodin-loaded PLGA nanoparticle (DGn and EDn) via modified solvent-emulsion-diffusion-evaporation method. Functional stability of prepared nanoparticles and in vitro physiological characterization including mean particle sizes distribution, polydispersity index, surface zeta potential, and morphological examinations were performed. Moreover, drug loading and encapsulation efficiency were also evaluated by measuring drug concentration through spectroscopy and HPLC method. Both drug nanoformulations demonstrated functional drug stability, 200─270 nm sizes with homogeneous particle distribution, negative surface zeta potential stability, and uniform spherical morphology. Moreover, nanoparticles showed in vitro controlled drug release pattern over 24 hours with 40─70% of drug depletion. Pharmacokinetics analysis was performed on sixteen rats equally distributed in four groups (DG, ED, DGn, and EDn). Pure drugs and nanoformulations were orally (10 mg/kg) administrated to animal model, and pharmacokinetic profiles of both drugs were evaluated. PLGA nanoparticles were significantly able to alter the pharmacokinetics of DG, while little improvement was observed for ED. Consequently, changes in pharmacokinetics of both drugs are attributed to size and surface characteristics of nanoparticles. DGn and EDn subsidize increased mean plasma residence time and maximize area under curve with decreased drug clearance rate. Resulting in vitro characteristics and in vivo pharmacokinetics data reveal the efficacy of DGn and EDn to be suitable nano-drug delivery modalities with improved bioavailability and pharmacological strength.
Self-sexualization in Relation to Sexual Harassment and Body Shame
Authors: Choi Dooyoung , Kang Ju-Young M. , Kim Jieun , Lee Ha Kyung
Published: December 2022

While many researchers examined several harmful consequences of the imposed or forced sexualization of women, still little is known about voluntary self-sexualization and its potential effects on women who engage in the practice. Although the idea that self-sexualization is self-fulfilling remains contentious, women who self-sexualize are naturally expected to receive sexualized attention, including unwanted attention. This study starts with the question of whether self-sexualizing women, including those who use self-sexualization as a source of power, experience sexual objectification, measured by nonphysical sexual harassment, and its negative consequence, measured by body shame. Furthermore, we investigate how age moderates the relationship. An online questionnaire was created and a total of 308 women completed the questionnaire. Structural equation modeling was conducted to test the hypothesized causal relationships from self-sexualization (self-empowering sexualization and no-power-intent self-sexualization) to nonphysical sexual harassment, which can lead to body shame. The results showed that the effects of self-sexualization are dependent on the intent for self-sexualization as well as the self-sexualizer’s age. While self-sexualization without intent to gain power can lead to increased sexual harassment incidents and body shame, mature women’s self-sexualization as a source of power does not lead to increased sexual harassment experiences nor increased body shame. However, unlike the mature women’s self-empowering sexualization, the young women’s self-sexualization, with or without intent to gain power, can lead to more sexual harassment experiences. The findings of this study indicate the need to uncover the various intentions for self-sexualization as well as their different effects.
Spectral Geometry and Riemannian Manifold Mesh Approximations: Some Autocorrelation Lessons from Spatial Statistics
Authors: Griffith Daniel
Published: December 2022

Awareness of the utility of spectral geometry is permeating the academy today, with special interest in its ability to foster interfaces between a range of analytical disciplines and art, exhibiting popularity in, for example, computer engineering/image processing and GIScience/spatial statistics, among other subject areas. This paper contributes to the emerging literature about such synergies. It more specifically extends the 2-D Graph Moranian operator that dominates spatial statistics/econometrics to the 3-D Riemannian manifold sphere whose analysis the Graph Laplacian operator monopolizes today. One conclusion is that harmonizing the use of these two operators offers a way to expand knowledge and comprehension.
Investigation of linear and non-linear functional connectivity within resting-state networks using graph theory in Parkinson's disease
Authors: Ahmadimehr Shakiba
Published: December 2022

Purpose
Parkinson's disease (PD) is widely known as a neurodegenerative disorder of the nervous system for which there is no cure. Accordingly, researchers can utilize neuroimaging techniques like functional magnetic resonance imaging (fMRI) to investigate neural activities in the brain non-invasively. Most previous research works construct brain graphs based on linear correlations for functional connectivity (FC) analysis. In this study, we compared linear and nonlinear functional connectivity methods.
Methods
The objective of our study is to implement 5 functional connectivity methods on 14 resting-state fMRI networks (RSNs) based on the FIND RSN template that is divided into 90 regions. Kernel Mutual information (KMI), a unique nonlinear connectivity approach based on Mutual information (MI), is also employed. Consequently, the validity of the methods was assessed using local graph measures and statistical analysis.
Results
The results show that nonlinear methods outperformed linear ones using the outcome of graph theory. In the non-linear functional connectivity methods, all seven graph measures showed a significant difference between two groups: healthy control (HC) and Parkinson's disease (PD), but only one graph measure showed a significant difference in the linear functional connectivity methods. Furthermore, while K-Corenness centrality has been utilized in previous studies to diagnose and assess various neurodegenerative illnesses, it is employed for the first time in our study to diagnose Parkinson's patients using fMRI data.
Conclusions
According to the findings of this study, nonlinear functional connectivity should be investigated in Parkinson's disease and other neurodegenerative diseases.
Generation of human haploid neural stem cells from parthenogenetic embryonic stem cells
Authors: Wang Haisong , Ma Xinrui , Niu Wenbin , Shi Hao , Liu Yidong , Ma Ningzhao , Zhang Nan , Sun Ying-Pu
Published: December 2022

Recently, haploid embryonic stem cells (haESCs) have been established in many species and widely used in forward and reverse genetic screening. Differentiated haploid cell line types in mammals are lacking due to spontaneous diploidization during differentiation that compromises lineage-specific screens. Human embryonic stem cells are widely used in basic and preclinical research. In this work, we report that human haESCs in extended pluripotent culture medium showed more compact colonies, higher efficiency in neural differentiation, and higher stability in haploidy maintenance, which effectively facilitated the derivation of haNSCs. Human haploid neural stem cells (haNSCs) can be generated by differentiation and maintain haploidy and multipotency to neurons and glia in the long term in vitro. After PiggyBac transfection, there were multiple insertion sites in the haNSC genome and the insertion sites evenly spread across all chromosomes. This is the first human haploid somatic cell line with a complete genome, proliferative ability and neural differentiation potential, which provides cell resources for recessive inheritance and drug targeted screening.
Reprocessing 2-D Airgun Seismic Reflection Data SALTFLU (Salt Deformation And Sub-Salt Fluid Circulation In The Algero-Balearic Abyssal Plain) In the Balearic Promontory and the Algerian Basin
Authors: Blondel Simon , Ford Jonathan , Lockwood Aaron , Ben Anna Del , Camerlenghi Angelo
Published: December 2022

In an ever more challenging context for the acquisition of seismic data in the Mediterranean Sea, reprocessing to improve the quality of legacy data has become increasingly important. This work presents the newly reprocessed, open access dataset SALTFLU acquired in the Algerian basin by the National Institute of Oceanography and Applied Geophysics (OGS) in 2012. We apply a ‘broadband’ reprocessing strategy adapted for offset-limited (3km streamer for a target 4 km below the sea level) airgun reflection seismic data acquired in deep water settings. We then assess if the reprocessed images provide new geological insights on the Mediterranean sub-surface. The workflow relies on an integrated approach combining geophysics and geological interpretation to iteratively build the velocity model. In this way we aim to tackle some of the challenges linked to imaging deep complex geological structures containing high velocity contrasts with 2-D, offset-limited seismic data. We first broaden the bandwidth of the data through multi-domain de-noising, deghosting and a source designature using an operator derived from the seabed reflection. We then perform iterative migration velocity analysis, pre-stack time migration and multiple attenuation in the Radon domain to obtain time-migrated images. The initial velocity model is derived from the resulting time migration velocities, and geologically driven model updates are generated using a combination of travel-time tomography, seismic interpretation of the major salt horizons and velocity gradient flooding. The gradient flooding aims to reproduce the large scale first-order velocity variations, while the travel-time tomography aims to resolve the smaller second-order velocity variations. The results improve our deep geological knowledge of the under-explored Algerian basin down to the base salt and the pre-salt. Fluid indicators are imaged within the Plio-Quaternary of the Algerian basin, which we interpret as thermogenic or biogenic gas sourced from either the Messinian Upper Unit or from the pre-salt, migrating through a hydro-fractured salt. The reprocessed data image lateral and vertical seismic facies variation within the Messinian units that could shed new light on the tectono-stratigraphic processes acting during the Messinian Salinity Crisis. It also reveals numerous previously unresolved volcanic structures within the Formentera basin.
Dynamic 3D Network Design for UAV Based Photogrammetry in mountainous terrain
Authors: Gargari Ali Mahdinezhad , Ebadi Hamid , Esmaeili Farid , Latifzadeh Sahar
Published: December 2022

Topographic mapping in mountainous areas encounters many challenges due to the potential impasse and lack of access to all locations. Unmanned Aerial Vehicles (UAVs) are an effective alternative to traditional field mapping in different environmental conditions. However, problems such as large-scale differences, gaps, and errors due to extreme elevation differences in these areas, hinders the use of UAV-based photogrammetry, thus reducing the quality and accuracy of the photogrammetric products and the final extracted map in mountainous areas. By designing an optimal flight network before UAV acquisition, the effect of these problems can be reduced. This paper proposes a method for planning the dynamic three-dimensional Imaging Network UAV in mountainous terrain based on digital elevation model (DEM) to ensure the uniformity of the scale in the photogrammetric blocks, avoid collision with obstacles, also gaps or data redundancy. The proposed method was implemented in a semi-mountainous area and the results showed that the large-scale changes among the images were reduced and the GSD was maintained as constant as possible. Also, planning UAV flight program based on the proposed algorithm increases the accuracy of the photogrammetric products.
Anti-obesity effect of the bacterial product, nisin
Authors: Al-Emarah Muslim , Kazerani Hamid Reza , Taghizad Fereidoun , Dehghani Hesam , Elahi Mohammad
Published: December 2022

Obesity is one of the most important metabolic disorder that predisposes individuals to other diseases. We investigated the effect of nisin, a bacteriocin produced by some bacteria, on obesity and some of its related parameters. Forty mice were randomly divided into four groups and received a placebo (saline) or nisin (25, 50, or 100 µg/kg, ip), daily, for 8 weeks. Bodyweight and food intake were measured weekly, and at the end of the experiment, the levels of fasting blood sugar, serum triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, and hepatic enzymes were tested, and red and white blood cell counts, haemoglobin concentration, mean corpuscular volume, mean corpuscular haemoglobin, and mean corpuscular haemoglobin concentration were determined. Finally, the expression levels of some obesity-related genes, including stearoyl-CoA desaturase-1 (SCD-1), glucose transporter-4 (GLUT4), zfp423, 422(ap2), and tumor necrosis factor-alpha (TNF-α) were assessed using RT-qPCR. After the experiment, the body weights, abdominal fat, and body mass index were significantly lower in the nisin-treated groups than in the control. The highest effect was observed with 50 µg/kg of nisin, and this dose caused a significant reduction in the total food intake. The expression of SCD-1, GLUT4, 422(ap2), and TNF-α decreased significantly following treatment with nisin. No significant differences were observed in the other studied parameters, and no toxic effects were observed for nisin under these experimental conditions. Our results suggest that nissin could have weight-protective effects.
Cobalt-based metalloporphyrins as efficient electro-catalysts for hydrogen evolution from acetic acid and water
Authors: Wang Zong , Liu Yin , Li Ting , He Yong-Zhen , Chen Yan-Lin , Jiang Xin-Yi , Ni Chun-Lin , Yang Le-Min , Liu Wei
Published: December 2022

Four molecular electrocatalysts based on cobalt complexes, CoT(X)PP (X = H (1), OH (2), CN (3), COOH (4)), were prepared from meso-tetra-p-X-phenylporphin (H2T(X)PP, X = H, OH, CN, COOH) by reaction with cobalt acetate to be used for electrolytic proton or water reduction. The electrochemical properties and the corresponding catalytic activities of these four catalysts were investigated by cyclic voltammetry. Controlled potential electrolysis with gas chromatography analysis confirmed that the turn-over frequencies (TOF) per mol of catalyst per hour were 42.4, 38.6, 55.5, and 70.1 mol H2 at an overpotential of 941.6 mV (in DMF) in the acetic acid solution containing catalyst. In neutral buffered aqueous solution (pH 7.0), these four molecular catalysts had TOF per mol of catalyst per hour of 352.53, 313.7, 473.4, and 714.6 mol H2, respectively, with an overpotential of 837.6 mV, indicating that complex 4 had better activity than complexes 1, 2, and 3. The Faraday efficiencies of complexes 1–4 were 99.1, 99.6, 100.4, and 99.0% at 72 h of consecutive reduction on a glassy carbon electrode, respectively. These results indicate that the electronic properties of the ligands play a crucial role in determining the catalytic activity of the cobalt complex and are consistent with the phenomenon that the catalytic activity of the benzene porphyrins is significantly increased in the presence of electron-withdrawing groups, and the CoT(COOH)PP is the most active catalyst.
Rigid-flexible-thermal coupling dynamics of hub and multi-plate system considering frictional contact
Authors: Yuan Tingting , Lei Bo , Liu Jinyang , Wu Yunli
Published: December 2022

A geometric nonlinear modeling approach for strong rigid-flexible-thermal coupling dynamics of the hub and multi-plate system considering frictional contact is proposed. Based on the absolute nodal coordinate formulation (ANCF), a thermal integrated ANCF thin plate element is developed, where the temperature field is expressed with Taylor polynomials to yield two-dimensional heat conduction equations. Different from the traditional coupling formulations, the influences of the attitude motion and structural deformation on the intensity of the solar radiation, the geometric nonlinearity of the plate as well as the frictional contact are taken into account. The normal contact is formulated by the penalty method, and the tangential friction considers the stick–slip transition. To solve the strong rigid-flexible-thermal coupling equations, a novel numerical method combining the modified central difference approach and the generalized-a method is proposed. Two validations are performed to verify the proposed thermal-structural coupling model, which proves the importance of the geometric nonlinearity and can capture the thermally induced vibration. Then the thermal-dynamic coupling analysis for the satellite and solar array multibody system in thermal environment is carried out. The dynamic characteristics of the thermally induced vibration can be successfully revealed by the rigid-flexible-thermal coupling model. Furthermore, it is indicated that the influence of contact and thermal load on the nonlinear behavior of the solar array deployment is essential, which demonstrates the feasibility of the proposed approach.
Photonic higher-order topological insulator with enlarged non-trivial bandgaps
Authors: Zhang Yuexin , Dai Xiaoyu , Xiang Yuanjiang
Published: December 2022

Recently, the emergence of higher-order topological insulators (HOTIs) has drawn extensive investigations. The unconventional bulk-hinge correspondence featuring in-gap corner or hinge states have been observed in diversified platforms like acoustics and photonics. However, three-dimensional (3D) photonic HOTIs are less attached due to the complicated properties of electromagnetic (EM) waves and narrow photonic bandgaps. In this article, we propose a photonic HOTI with a simple multilayer structure to support hinge states. By inserting a central metallic pillar in the unit cell, the 3D bandgap can be extended to 17.9%, allowing for pure and distinguishable surface and hinge modes. Free from adjusting the distance between adjacent dielectric rods to construct a topological interface, the lattice distortions can be achieved by controlling the geometrical length of sub-lattices, which providing a reconfigurable and flexible scheme to realize the robust hinge and surface wave transmission. Our findings usher the door for high-performance topological optical apparatus with efficient one-way light propagation and energy concentration.
High-performance IN738 superalloy derived from turbine blade waste for efficient ethanol, ethylene glycol, and urea electrooxidation
Authors: Hefnawy Mahmoud A. , Medany Shymaa S. , El-Sherif Rabab M. , El-Bagoury Nader , Fadlallah Sahar A.
Published: December 2022

In this work, the IN738 superalloy used previously in gas turbines was recycled and used as a working electrode for the electrooxidation of different fuels, namely, ethylene glycol, ethanol, and urea. The electrocatalytic efficiency of the electrode was studied by cyclic voltammetry, chronoamperometry, and electrochemical impedance. Several kinetics parameters like diffusion coefficient, Tafel slope, rate constant, and activation energy were calculated. The modified electrode was characterized as received using XRD, SEM, and EDAX to elucidate the crystal structure and surface morphology before and after electrochemical oxidation. The anodic current densities of electrochemical oxidation of ethanol, ethylene glycol, and urea were 29, 17, and 12 mA.cm-2, respectively, in an alkaline solution at a potential 0.6 V (vs. Ag/AgCl). The kinetic parameters like diffusion coefficients for ethanol, ethylene glycol, and urea were equaled to 1.5 10-6, 1.03810-6, and 0.6410-6 cm2 s-1. The charge transfer resistances were estimated for electrooxidation of different fuels by electrochemical impedance (EIS).
Dissemination of metallo-β-lactamase-producing Pseudomonas aeruginosa in Serbian hospital settings: expansion of ST235 and ST654 clones
Authors: Kabic Jovana , Fortunato Gianuario , Vaz-Moreira Ivone , Kekic Dusan , Jovicevic Milos , Pesovic Jovan , Ranin Lazar , Opavski Natasa , Manaia Célia M. , Gajic Ina
Published: December 2022

Background: Pseudomonas aeruginosa is one of the most common nosocomial pathogens worldwide. Limited information on beta-lactamase-producing P. aeruginosa in Serbia is available. The aim of this nationwide study was to investigate the molecular characteristics of metallo-β-lactamase (MBL)-producing P. aeruginosa in Serbia, to characterize underlying resistance mechanisms, to analyze the genetic context of detected MBL genes and clonal relationship between isolates harboring genes encoding MBL.
Methods: A total of 320 isolates of P. aeruginosa were identified out of 5334 bacterial isolates collected from 2018 to 2021. Carbapenem-resistant P. aeruginosa (CRPA) were screened for the presence of blaVIM, blaIMP, and blaNDM, genes whereas MBL-positive isolates were tested for the presence of the genes blaCTX-M-2, blaPER, blaTEM, blaSHV, blaVEB, and blaGES. Multilocus sequence typing and phylogenomic analysis were performed for P. aeruginosa producing MBL.
Results: P. aeruginosa isolates were recovered from the lower respiratory tract (n=120; 37.5%), wound specimens (n=108; 33.75%), and urine samples (n=71; 22.2%), mainly from patients admitted to the intensive care unit (n=178; 55.6%). CRPA isolates accounted for 43.1% (n=138) of the tested P. aeruginosa and 31 out of these were blaNDM-1-positive (22.5%). Colistin was the most effective antibiotic, with a resistance rate of 0.3%. MLST analysis of all blaNDM-1-positive isolates (n=31) revealed the occurrence of ST235 (n=25) and ST654 (n=6), mostly confined to Serbia. The distribution of beta-lactamase encoding genes in these isolates suggested clonal dissemination and possible recombination: ST235/blaNDM-1, ST235/blaNDM-1/blaPER-1, ST654/blaNDM-1, ST654/blaNDM-1/blaPER-1, and ST654/blaNDM-1/blaGES-5.
Conclusions: High-risk clones ST235 and ST654 identified for the first time in Serbia, are important vectors of acquired MBL and ESBL in Serbia and their associated multidrug resistance (MDR) phenotypes represent a cause for considerable concern.
A available-flow neural network for solving the dynamic groundwater network maximum flow problem
Authors: Zhang Baowen , Huang Wei , Zhao Fengnian
Published: December 2022

The normal operation of infrastructure networks such as groundwater networks maintains people's life and work. Therefore, it is of great significance to estimate the residual flow when these networks are damaged to evaluate their anti-risk ability. This paper abstracts these problems as the damage-network time-varying maximum flow problem (DTMFP), where the arc capacity in the network is set as a time-varying function. Since the water network is subject to electric-driven periodic changes, and the network damage is defined by some arcs or nodes in the network doesn't work at all. Although the existing maximum flow algorithms such as Cai-Sha can solve the time-varying maximum flow problem, the uncertainty of the network topology that suffers from random damage makes it difficult for the existing maximum flow algorithms to solve such problems. The uncertainty of network topology which suffer random damage makes such problems difficult to solve by existing maximum flow algorithms. Therefore, the key to solve DTMFPs is to find the topology of damaged network. In this paper, we propose an available flow neural network (AFNN) algorithm for solving DTMFPs. The idea of the AFNN algorithm is to determine the network topology through the back-information neural networks (BINN) algorithm at first, then obtain the residual maximum flow through the single-path neural networks (SPNN) algorithm. In the BINN algorithm, the departure node is continuously activated for a given time period and sends waves along the network to the destination node. The wave contains arcs which can be activated. The Utah channel impact response wireless sensor network, American north marin water district network and New York road network are used to confirm the effectiveness of the proposed AFNN algorithm.
Modeling and Investigation of Rear-Passivated Ultrathin CIGS Solar Cell
Authors: Boukortt Nour , Patanè Salvatore , Adouane Mabrouk
Published: December 2022

In this paper, we use numerical simulations to investigate ultrathin Cu (In1-xGax) Se2 solar cells. In the first part, we focus on the cell configuration in which the PV parameters fit and match the fabricated cell characteristics. Our goal is to investigate the impact of different loss mechanisms such as interface trap density (Dit) and absorber trap density (Nt) in different cell pitch sizes on cell performance. Dit defines the amount of carrier’s traps at CIGS/Al2O3 interface to recombine with photogenerated carriers. Nt defines the amount of carrier traps in the absorber layer. It has been found that the recombination via traps is the major loss mechanism in the investigated cell. Further numerical investigations quantify significant improvements in cell performance for different cell pitch sizes, absorber doping densities, Ga content, and graded bandgap at a fixed opening width in the Al2O3 layer. Consequently, for tandem configuration, the optimized single u-CIGS cell has been used as a top cell with a PERT silicon cell which aroused this recent decade as a promising strategy to achieve maximum efficiencies. The results from these simulations provide insights for ultrathin film CIGS solar cell optimization.
Long-Term Effectiveness and Safety Of Endoxifen In The Treatment Of Acute Bipolar Mania: A Case Report
Authors: CHAKLADAR ABHISHEK , KUMAR NAND , VERMA ROHIT , BRAR MANMEET KAUR
Published: December 2022

Antipsychotic drugs and mood stabilizers as mono or combination therapy are first-line agents in the treatment of the manic phase of bipolar I disorder. Endoxifen a potent inhibitor of the protein kinase C (PKC) signaling pathway, is efficacious in the control of acute bipolar mania, at doses of 8 mg, for a period of 3-weeks. However, there is a dearth of data about the long-term use of endoxifen. Here we describe a case of acute bipolar mania not able to tolerate clozapine therapy, efficaciously controlled with long-term use (9-weeks) of endoxifen 8 mg, without any adverse effects, along with complete remission of manic symptoms.
Comparative Analysis of SAZZ and ZETA Converter and MPPT techniques in SPV
Authors: Vivekanandan S. , Ramkumar M. Siva
Published: December 2022

The authors have requested that this preprint be removed from Research Square.
Vulnerability assessment of irrigation water requirement to climate change at Governorates level, Egypt
Authors: Ads Abdelhamid , Pingale Santosh M. , Khare Deepak
Published: December 2022

The agricultural division is the highest consumer of water in Egypt, and it is facing crop yield reduction due to climate change. Irrigation technologies are a highly recommended adaptation option to meet the proposed change. Egypt`s financial resources allocated to climate change adaptation plans are limited. Therefore, determining the most vulnerable governorate in terms of Irrigation Water Requirements (IWR) to climate change is essential. This study aims to assess the vulnerability of IWR to climate change at the governorate level. Reference evapotranspiration and precipitation change were selected for exposure factors, sensitivity factors, soil type, and economic value of irrigation water. Finally, we identified education, poverty, and organizational capacity for adaptive capacity factors. Six climate model data were used under the shared socioeconomic pathway scenarios (SSP126, SSP245, SSP370, and SSP585) for the period (2040–2060). The results showed nine governorates (Al Minya, Asyut, Shamal Sina, Suhaj, Al Buhayrah, Al Fayyum, Al Isma`iliyah, Ash Sharqiyah, and Bani Suwayf) with the highest and high vulnerability degrees found in the country's middle and north region. Four governorates (Ad Daqahliyah, Aswan, Al Gharbiyah, Bur Sa`id) have the lowest vulnerability degree under the climate change scenarios (SSP126, SSP245, and SSP370), and one governorate (Aswan) has the lowest vulnerability degree under the SSP585 scenario. The study results help the decision-makers choose the best adaptation plans and support adapting effective mitigation strategies.
Prognostic effect of radiotherapy on different colorectal cancer histological subtypes and tumor sites
Authors: Yao Nan , Xu Guoshuai , Li Wenqiang , Dou Ruixue , Duan Ning , Shi Wenzai , Yu Guoyong , Qu Jun
Published: December 2022

Background: The effect of radiotherapy (RT) may differ according to colorectal cancer (CRC) histological subtypes including adenocarcinoma, mucinous adenocarcinoma (MC), and signet-ring cell carcinoma (SR). This study analyzed the prognosis of three pathological CRC types and focused on RT's prognostic significance on three CRC histological subtypes.
Methods: Patients diagnosed with adenocarcinoma (n=54,174), MC (n=3,813), and SR (n=664) in the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database (2010–2017) were evaluated. Cox regression models and competitive risk models were built to assess the effect of RT on the risk of CRC-associated death.
Results: Compared with adenocarcinoma patients, SR patients were associated with a 1.28-fold (HR=1.28, 95% CI: 1.16-1.42) risk of death. In the site-specific analyses, adenocarcinoma patients who received RT exhibited an increased risk of death (HR = 1.09, 95% CI: 1.03-1.15). RT did not show any prognostic influence for MC patients (HR = 0.96, 95% CI: 0.77-1.21). In SR patients. RT could reduce the risk of death (HR = 0.61, 95% CI: 0.39-0.95). After taking competing risk events (non-CRC-related death) into consideration. The results remained unchanged.
Conclusions: Our study suggests that SR patients exhibited a worse OS (overall survival) than adenocarcinoma patients, and the effect of RT varied according to CRC histological subtypes.
An improved Dissipative Particle Dynamics Method for the Liquid-Particle Two-Phase Flow in Microchannels
Authors: Dong Hua , Wu Xu , Fan Liang-Liang , Zhao Liang
Published: December 2022

Liquid-particle two-phase flow in microchannels is widely applicable in the microfluidic fields. The standard dissipative particle dynamics (DPD) method has been previously employed to study the liquid-particle two-phase flow in microchannels. However, the standard method cannot accurately simulate the real two-phase flow in microchannel. In the present study, by changing the energy unit and fitting the characteristic curve between the random force coefficient and the Schmidt number, the value of the Schmidt number is modified to be 355, which can be used to accurately simulate the flow process of the real fluid. In addition, a new logarithmic relationship between the conservative force coefficient and the radius of the particle is established. The simulation results of the particle migration are in good agreement with the Matas theory with an error of 1.5%. The improved DPD method would be of great help for the microfluidic applications and the research on the mechanism of multiphase flow in micro scale.
Analysis of serum reproductive hormones and ovarian genes in pubertal female goats
Authors: Zhu Yanyun , Ye Jing , Qin Ping , Yan Xu , Gong Xinbao , Li Xiaoqian , Liu Ya , Li Yunsheng , Yu Tong , Zhang Yunhai , Ling Yinghui , Wang Juhua , Cao Hongguo , Fang Fugui
Published: December 2022

Background
Age at puberty is an important factor affecting goat fertility, with endocrine and genetic factors playing a crucial role in the onset of puberty. To better understand the mechanisms underlying puberty onset in goats, reproductive hormone levels were analyzed by ELISA and ultraperformance liquid chromatography–multiple reaction monitoring–multistage/mass spectrometry, and RNA sequencing was performed to analyze ovarian genes.
Results
Serum follicle stimulating hormone, luteinizing hormone, estradiol, 11-deoxycortisol, 11-deoxycorticosterone, corticosterone, cortisone, and cortisol levels were found to be higher but progesterone were lower in pubertal goats as compared to those in prepubertal goats (P < 0.05). A total of 18,139 genes were identified in cDNA libraries, and 75 differentially expressed genes (DEGs) were identified (|log2 fold change| ≥ 1, P ≤ 0.05), of which 32 were significantly up- and 43 were down-regulated in pubertal goats. Gene ontology enrichment analyses indicated that DEGs were mainly involved in “metabolic process,” “signaling,” “reproduction,” and “growth.” Further, DEGs were significantly enriched in 91 Kyoto Encyclopedia of Genes and Genomes pathways, including estrogen signaling pathway, steroid hormone biosynthesis, and cAMP signaling pathway. Bioinformatics analysis showed that PRLR and THBS1 were highly expressed in pubertal ovaries, and ZP3, ZP4, and ASTL showed low expression, suggesting their involvement in follicular development and lutealization.
Conclusions
To summarize, our results indicated that reproductive hormones and ovarian DEGs play an essential role in regulating puberty in goats. Further studies are warranted to comprehensively explore the functions of DEGs in goat puberty.
Body modifications in borderline personality disorder patients: prevalence rates, link with non-suicidal self-injuries, and related psychopathology
Authors: Blay Martin , Hasler Roland , Nicastro Rosetta , Pham Eléonore , Weibel Sébastien , Debbané Martin , Perroud Nader
Published: December 2022

Background
Borderline Personality Disorder (BPD) is a potentially severe personality disorder, characterized by difficulties in emotion regulation and control of behaviors. It is often associated with non-suicidal self-injuries (NSSI). Borderline personality features have also been linked to body modifications (BMs). However, the prevalence of BMs, the link between BMs and NSSI, and between BMs and several psychopathology dimensions (e.g. borderline severity, emotion regulation, impulsivity …) remains understudied in patients with BPD. This study aims to fill this gap, and to provide further evidence on the link between NSSI and BMs.
Methods
We used data from a psychiatric outpatient center located in Switzerland (n = 116), specialized in the assessment and treatment of BPD patients. Patients underwent several semi-structured interviews and self-report psychometric scales at the arrival, and the data were retrospectively analyzed.
Results
We found that 70.69% of the patients had one piercing or more, and 69.83% were tattooed. The total score of body modifications and the total number of piercings score of piercings were significantly positively associated with NSSI and the SCID BPD total score. The association with the SCID score was mainly driven by the “suicide and self-damaging behaviors” item and the “chronic feeling of emptiness” item. A significant association was found between total number of piercings and emotion dysregulation. On the other hand, the self-reported percentage of body covered by tattoos score was specifically associated with the sensation seeking subscale of the UPPS-P.
Conclusion
This study provides evidence on the prevalence of BMs in BPD patients, and on the link between BMs and NSSI in this population, suggesting a role of emotion regulation in the link between both constructs. These results also suggests that tattoos and piercings may be differentially linked to specific underlying psychological mechanisms. This calls for further considerations of body modifications in the assessment and care of BPD patients.