bluuebunny/crossref_metadata_2025 huggingface dataset:
Сучасні підходи до лікування туберкульозного менінгоенцефаліту
Authors: Ніколаєва О.Д.
Published: February 2023

Епідемія ВІЛ-інфекції в Україні збільшує захворюваність на лікарсько-стійкі форми туберкульозу, спричиняє розвиток позалегеневих форм, у тому числі центральної нервової системи (ЦНС). Ефективність лікування туберкульозу ЦНС залежить від режиму терапії з урахуванням тесту медикаментозної чутливості, бактерицидної та стерилізувальної дій протитуберкульозних препаратів, а також терапевтичної концентрації в церебральній мозковій рідині та тканинах мозку. При туберкульозі ЦНС лікування потрібно обов’язково проводити з урахуванням препаратів, які перетинають гематоенцефалічний бар’єр (ізоніазид, рифампіцин, піразинамід, протіонамід, циклосерин, фторхінолони, лінезолід, карбапенеми). Тяжкий стан хворих, порушення ковтання потребують інтенсивної протитуберкульозної терапії з внутрішньовенним і внутрішньом’язовим уведенням препаратів і симптоматичного лікування. Стандартна пероральна протитуберкульозна терапія за чинним протоколом у разі призначення лікування після 3 тижнів від початку захворювання та при ураженні мозку позитивного ефекту не дає. Тяжкі хворі з геміпарезом, бульбарним синдромом, багатовогнищевим ураженням мозку потребують індивідуальних підходів до лікування.

Із метою підвищення ефективності лікування туберкульозу ЦНС використовують інтратекальне введення препаратів. Основними перевагами цього способу введення медикаментів вважають можливість забезпечити максимальну концентрацію активної речовини в мозкових тканинах і лікворі. Крім того, інтратекально можна ввести ліки, які не проникнуть крізь гематоенцефалічну перетинку. Завдяки вливанню ліків безпосередньо в кінцеву цистерну вдається скоротити дозування препаратів і мінімізувати їхній системний небезпечний вплив.

У режим лікування туберкульозу ЦНС включають інтратекальне введення левофлоксацину в дозі 1000 мг, ізоніазиду, меропенему, амікацину. Ми для інтратекального введення використовували фізіологічний розчин ½ (3-5 мл левофлоксацину + 5-10 мл фізіологічного розчину). До левофлоксацину додають також дексаметазон у дозі 8-12 мг залежно від стану хворого. При отриманні позитивного ефекту на підставі клінічного й лабораторного моніторингу перебігу лікування переходять на стандартну схему терапії з використанням таблетованих форм препаратів.
Залучення неурядових організацій до активного виявлення нових випадків ТБ
Authors: Сметаніна О. , Окромешко С. , Павлова О.В. , Дравніце Г. , Гамазіна К.О.
Published: February 2023

Міжнародна організація РАТН упроваджує проєкт «Підтримка зусиль у протидії туберкульозу в Україні», що фінансується Агентством США з міжнародного розвитку (USAID). Проєкт співпрацює з неурядовими організаціями (НУО) у 12 областях – Дніпропетровській, Донецькій (на підконтрольних Україні територіях), Запорізькій, Кіровоградській, Київській, Львівській, Миколаївській, Одеській, Полтавській, Херсонській, Черкаській, Чернігівській – для надання комплексного пацієнторієнтованого пакета послуг хворим на лікарсько-стійкий туберкульоз (ЛС-ТБ) для покращення їхньої прихильності до лікування, а також обстеження осіб, які були в контакті з узятими на супровід хворими на ЛС-ТБ. Ця робота дала змогу підвищити рівень виявлення нових випадків ТБ і вчасно розпочати його лікування.

Фахівці РАТН розробили алгоритм роботи соціальних працівників із контактними особами, інформаційні пам’ятки для контактних осіб і соціальних працівників, а також провели серію тренінгів для НУО з метою покращення навичок їхньої роботи з контактними особами та вдосконалення співпраці з медичною службою. Починаючи з квітня 2020 р. соціальні працівники проводили опитування взятих на супровід хворих на ЛС-ТБ для виявлення їхніх сімейних і близьких контактів, потім звіряли цю інформацію із закріпленими лікарями для підтвердження нових, іще не обстежених медичною службою контактних осіб. Тоді соціальні працівники відвідували нових контактних осіб удома, мотивували та доводили їх до обстеження, а за потреби – до початку лікування ТБ, надаючи їм необхідну підтримку в транспортуванні до медзакладу тощо. Також соціальні працівники мали справу з контактними особами, попередньо виявленими медпрацівниками, з метою забезпечення їх повторного обстеження згідно з рекомендаціями лікаря.

Із квітня 2020 р. до жовтня 2022 р. медичні працівники обстежили 1647 контактних осіб 1299 індексних пацієнтів, які були на супроводі НУО. Соціальні працівники додатково виявили 1052 контактні особи, з яких 1043 особи (99 %) були обстежені (табл.). Було діагностовано 35 нових випадків ТБ та 8 – латентної туберкульозної інфекції (ЛТБІ). Решта контактних осіб були здорові й отримали пам’ятки з інформацією про те, що потрібно повторити обстеження в разі, коли виникнуть симптоми ТБ. Також завдяки соціальним працівникам були повторно обстежені 363 контактні особи, серед яких було діагностовано 8 випадків ТБ та 21 випадок ЛТБІ.

Отже, залучення НУО продемонструвало високу ефективність у виявленні пропущених випадків ТБ і вчасному початку їх лікування за умови тісної співпраці НУО з медичною службою.
Лікування туберкульозу з резистентністю до рифампіцину за виключно пероральною схемою, що містить нові препарати: результати наприкінці терапії
Authors: Труш О.
Published: February 2023

Обґрунтування. У грудні 2018 р. Всесвітня організація охорони здоров’я закликала до проведення операційних досліджень і впровадження скорочених схем лікування з виключно пероральним прийомом препаратів, пов’язаних із покращенням результатів лікування та зниженням рівня смертності від стійких до рифампіцину й хіміорезистентних форм туберкульозу (РР/ХРТБ). Ми спостерігали за когортою пацієнтів у Житомирі та проаналізували кінцеві результати лікування й небажані явища, які можуть викликати зацікавленість.

Матеріали та методи. Ми провели неконтрольоване лонгітюдне квазіекспериментальне дослідження. Усі особи з діагнозом РР/ХРТБ у Житомирі, які відповідали критеріям включення та виключення й дали згоду на участь у дослідженні, були залучені до процесу в період із січня 2019 р. по березень 2021 р. Пацієнти без резистентності до фторхінолонів отримували бедаквілін, лінезолід, левофлоксацин, клофазимін і циклосерин. Пацієнти з резистентністю до фторхінолонів отримували бедаквілін, лінезолід, деламанід, клофазимін і циклосерин. Одним із важливих компонентів нашої інтервенції була комплексна мультидисциплінарна підтримка пацієнтів. Це передбачало такі заходи, як програма з підвищення обізнаності про процес лікування, інтенсивна підтримка та моніторинг прихильності до лікування, психосоціальна, орієнтована на пацієнта підтримка під час стаціонарного й амбулаторного лікування, а також залучення громадськості до надання підтримки.

Результати. За період дослідження до лікування було залучено 300 пацієнтів. Загальний показник успішності сягнув 78 %. Із-поміж наших пацієнтів 21 % повідомили про принаймні 1 серйозне небажане явище та 27 % – про принаймні 1 небажане явище 3 або 4 ступеня.

Висновки. Повністю пероральний короткостроковий режим, який використовувався в цьому дослідженні, продемонстрував високий рівень успіху та зіставні небажані явища за програмних умов. Ми також вважаємо, що комплексна та мультидисциплінарна модель психосоціальної підтримки відіграє важливу роль у досягненні низького показника кількості осіб, втрачених для подальшого спостереження.
INTERNALISASI PENDIDIKAN KARAKTER DI PERGURUAN TINGGI (STUDI KASUS DI JURUSAN TARBIYAH STAIN PONOROGO)
Authors: Wathoni Kharisul
Published: February 2023

Character education is essentially an effort to develop the moral intelligence of students to behave noble (noble character). Thus forming efforts in the institutional character does not stop until the secondary level but it should be up to the college level. From the results of research studies conducted in STAIN Ponorogo in this case an institutional case study at Tarbiyah Department has made efforts to internalize the character education to student which are through three patterns: first, conducted in the learning process in the lecture; The second, conducted in the process of academic administrative services; The third, carried through extracurricular activities and student intracuricular followed by majors Tarbiyah STAIN Ponorogo. The character values are internalized are: honesty, discipline, religious, creative, self-reliance, responsibility, tolerance, communicative and responsibility. Pendidikan karakter secara esensial adalah sebuah upaya mengembangkan kecerdasan moral peserta didik agar mempunyai perilaku yang mulia (noble character). Dengan demikian upaya penanaman karakter secara kelembagaan tidak hanya berhenti hingga jenjang menengah namun seharusnya hingga jenjang perguruan tinggi. Dari hasil kajian penelitian yang dilakukan di STAIN Ponorogo dalam hal ini studi kasus pada Jurusan Tarbiyah- secara kelembagaan telah melakukan upaya internalisasi pendidikan karakter kepada mahasiswa dalam hal ini melalui tiga pola: pertama, dilakukan dalam proses pembelajaran di perkuliahan; kedua, dilakukan dalam proses pelayanan akademik administratif; ketiga, dilakukan melalui kegiatankegiatan ekstrakulikuler maupun intrakulikuler kemahasiswaan yang diikuti oleh mahasiswa jurusan Tarbiyah STAIN Ponorogo. Adapun nilai-nilai karakter yang diinternalisasikan adalah: kejujuran, kedisiplinan, religius, kreatif, kemandirian, tanggung jawab, toleransi, komunikatif dan tanggung jawab.
Pendampingan Pembuatan Formula Krim Lulur Scrub Beras Putih dengan Kalkulator Jamu di Paguyuban Jamu Gendong Tresno Asih, Depok Jawa Barat
Authors: Kusuma Ika Maruya , Hidayat Taufik , Abdillah Mohammad Fadhli
Published: February 2023

Paguyuban Jamu Tresno Asih is one of the traditional herbal medicine communities in Depok, West Java. However, over time the number of members has decreased, this is due to a decrease in the interest of members of the Paguyuban Jamu Tresno Asih to produce and sell herbal medicine. The purpose of this partnership is to assist herbal sellers in making white rice scrubs with a herbal calculator which aims to increase the variety of products. The activities carried out include preparation, counseling and workshops on herbal calculators and making white rice scrubs and evaluations. The results of the evaluation of this activity showed that the white rice scrub cream with a herbal calculator it was easy to understand and the results of the organoleptic scrubs produced showed suitability. The increase percentage value of each understanding obtained for the function of the scrub cream is 63.63%; understanding of the ingredients of scrub cream 59.09%; understanding of the meaning and process of making scrub cream 36.37% and 31.82%. The herbal medicine seller at the Paguyuban Jamu Tresno Asih are interested in producing and selling white rice scrub cream as a product variation.
Edukasi Gizi Seimbang Lansia dan Pemeriksaan Kesehatan pada Lansia Komunitas Olahraga Woodball
Authors: Yunieswati Wilda , Yulianingsih Ika , Gery Muhammad Ishaq
Published: February 2023

Elderly is a group susceptible to non-communicable diseases due to a decrease in the function of the body's organs and a decrease in the body's immune system. Education related to balanced nutrition and health & nutritional status checks of the elderly are carried out to reduce the risk of non-communicable diseases such as obesity and hypertension in the elderly. The targets involved are elderly people from the Pamulang WoodBall Club (PWbC) Community, South Tangerang City. Education related to balanced nutrition for elderly is provided by lecture and discussion methods using leaflet. Meanwhile, a health & nutritional status checks was carried out by measuring weight, height and blood pressure. The percentage increase in target knowledge related to balanced nutrition is 41.4%, so it can be concluded that there was an increase in knowledge of balanced nutrition in the elderly. Most of the elderly were overweight (30.4%) and obese (30.4%) and had pre-hypertension (43.5%) and hypertension (26.1%).
Pemanfaatan Rambut Jagung (Zea mays L.) Menjadi Teh Herbal “KoNsilk” kepada Kader Puskesmas Perumnas 2 Kota Pontianak
Authors: Wijianto Bambang , Fahrurroji Andhi , Yuswar Muhammad Akib , Riza Hafrizal
Published: February 2023

The impact of the Covid-19 pandemic is felt by the people of Pontianak, in the economic, sociocultural, and health fields. One of the prime commodities in Pontianak is corn farming. The aim of the PKM Program is to innovate corn-based processed products. This PKM activity began with outreach to the heads and employees of the Puskesmas, as well as identifying health cadres as potential participants in training related to using corn silk as herbal tea drinks. Training on using corn silk as herbal tea drinks for cadres was carried out offline and interactively using leaflets, videos, and hands-on practice. Evaluation and monitoring activities are carried out using a Google form (pre-test and post-test). The results of the PKM activity showed success in understanding the cadres with good knowledge when the pre-test was carried out by only ten people (30.30%). After being given knowledge training, respondents in the good category amounted to 30 people (90.90%). PKM activities targeting UPT Puskesmas Perum II cadres increased the ability of cadres to utilize corn silk waste in herbal tea. The next activity is expected to be able to assist so that the resulting product obtains a permit.
Cover, Content, and Editorial Note from Pengabdianmu J Pengabdian Masyarakat Vol. 8 No. 1 January 2023
Authors: PengabdianMu J Pengabdian Masyarakat Chief Editor of
Published: February 2023

Assalamu’alaikum Wr. Wb.

Dear reader, now PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat re-published on Volume 8 Issue 1 January 2023. The publication of PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat certainly participate in disseminating the results of community services in science and technology development conducted by lecturers and researchers especially from UMPR and other universities.

This edition contains 16 articles consisting of Education, Social and Political, Agriculture, and Health Science topics. Editorial boards are fully aware that there are still room for improvement in this edition, hence with all humility willing to accept constructive suggestions and feedback for improvements to the publication for the next editions.

The editorial board would like to thank the University, all editors and reviewers, and contributors of the scientific articles who have provided the repetoire in this issue. We hope that all parties, especially the contributors of the articles, could re-participate for the success of the publication in the next edition on March 2023.

 

Wassalamu’alaikum Wr. Wb.
NUSANTARA IN FRONT OF MAKASSAR STRAIT: A REVIEW OF INTERNATIONAL LAW OF THE SEA
Authors: Judhariksawan Judhariksawan , Daud Aidir Amin , Tandungan Edmondus Sadesto
Published: February 2023

Relocation of the national capital of Indonesia to the Borneo region is not only fraught with considerations of the socio-economic, political, and physical environment. The safety factor is also a very important aspect because the capital city is the center of gravity of the country. Nusantara, the new capital city, directly faces the Makassar Strait which has been designated as an archipelagic sea lane. An archipelagic sea lane must be subject to the international law of the sea, especially the United Nations Convention on the Law of the Sea (UNCLOS) 1982. Foreign voyages and flights have the right of normal mode and continuous passage through archipelagic sea lanes. Therefore, they cannot be blocked. The right of passage is not only granted to merchant ships but also to military ships and even submarines. The extent of the security threat to the capital due to the abovementioned legal regime is analyzed by normative legal research, using a conceptual approach to the legal norms governing the sea lane. This study aims to provide an overview of the legal norms that apply to the Makassar Strait as a consideration in developing a defense and security strategy for the national capital, the archipelago. In conclusion, Nusantara in the Makassar Strait must pay attention to the international law of the sea norms in preparing the defense and security strategy for the new national capital city.
A Long-Term View of Refugee Flows from Ukraine: War, Insecurities, and Migration
Authors: Teke Lloyd Armağan , Sirkeci Ibrahim
Published: February 2023

This article examines the exodus of migrants from Ukraine in the context of the Russian invasion, making use of the conflict model of migration. We argue that Ukraine has long been characterized by insecurities which have already fueled large waves of emigration from the country. Indeed, the most recent phase of Ukrainian emigration should be seen as a continuation of the ongoing tendency of people residing in the country to seek escape from the overarching conditions of insecurity there. Earlier migrations from Ukraine have also established a culture of migration which has mediated the outflow of Ukrainians during the current crisis. Ukrainians who had already harboured inclinations to leave the country and who were possessed of the necessary capabilities (i.e. social capital, financial capital, human capital and physical ability) became mobile at the onset of the invasion in February, while many others were left behind. At the same time, the welcoming attitude of many European states has been key to the fast and safe exodus of Ukrainian migrants thus far.
Die stille Gesellschaft in der Krise und Insolvenz
Authors: Loewit Felix
Published: February 2023

Dogmatisch fundierte Antworten auf offene Fragestellungen Rechtsprechung, Lehre und selbst die Gesetzgebung beschäftigen sich seit mehreren Jahrzehnten mit dem Thema "Krise und Insolvenz der stillen Gesellschaft". Die Einführung des Eigenkapitalersatz-Gesetz 2004 (EKEG) sowie die Entscheidung OGH 6 Ob 204/16t trafen zwar wesentliche Klarstellungen, insbesondere hinsichtlich der Behandlung des stillen Gesellschafters in der Insolvenz des Inhabers. Gleichzeitig entstanden dadurch allerdings auch neue Abgrenzungsprobleme und Fragestellungen an der Schnittstelle zwischen Gesellschafts- und Insolvenzrecht. Dieses Buch schließt die bestehenden Lücken, indem es sämtliche einschlägige Fragestellungen behandelt und dogmatisch fundierte, in sich konsistente Antworten liefert. Das betrifft etwa die Qualifizierung der stillen Einlage als Fremd- oder Eigenkapital oder als eigenkapitalersetzend sowie die – davon abhängige – Behandlung des stillen Gesellschafters in der Insolvenz des Inhabers.
Integrated genetic and clinical prognostic factors for aggressive adult T-cell leukemia/lymphoma
Authors: Kameda Takuro , Kataoka Keisuke , Kamiunten Ayako , Hidaka Michihiro , Miyoshi Hiroaki , Nakano Nobuaki , Nosaka Kisato , Yoshimitsu Makoto , Yasunaga Jun-ichirou , Kogure Yasunori , Shide Kotaro , Miyahara Masaharu , Sakamoto Takashi , Akizuki Keiichi , Hidaka Tomonori , Kubuki Yoko , Koya Junji , Kawano Noriaki , Yamashita Kiyoshi , Kawano Hiroshi , Toyama Takanori , Maeda Kouichi , Marutsuka Kosuke , Imaizumi Yoshitaka , Kato Koji , Sugio Takeshi , Tokunaga Masahito , Tashiro Yukie , Takaori-Kondo Akifumi , Miyazaki Yasushi , Akashi Koichi , Ishitsuka Kenji , Matsuoka Masao , Ohshima Koichi , Watanabe Toshiki , Kitanaka Akira , Utsunomiya Atae , Ogawa Seishi , Shimoda Kazuya
Published: February 2023

The prognosis of aggressive adult T-cell leukemia/lymphoma (ATL) is poor, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment. In order to identify favorable prognostic patients after intensive chemotherapy, and who therefore might not require upfront allo-HSCT, we aimed to improve risk stratification of aggressive ATL patients aged <70 years. The clinical risk factors and genetic mutations were incorporated into risk modeling for overall survival (OS). We generated the m7-ATLPI, a clinicogenetic risk model for OS, that included the ATL prognostic index (PI) (ATL-PI) risk category, and non-silent mutations in seven genes, namely TP53, IRF4, RHOA, PRKCB, CARD11, CCR7, and GATA3. In the training cohort of 99 patients, the m7-ATLPI identified a low-, intermediate-, and highrisk group with 2-year OS of 100%, 43%, and 19%, respectively (hazard ratio [HR] =5.46; P<0.0001). The m7-ATLPI achieved superior risk stratification compared to the current ATL-PI (C-index 0.92 vs. 0.85, respectively). In the validation cohort of 84 patients, the m7-ATLPI defined low-, intermediate-, and high-risk groups with a 2-year OS of 81%, 30%, and 0%, respectively (HR=2.33; P=0.0094), and the model again outperformed the ATL-PI (C-index 0.72 vs. 0.70, respectively). The simplified m7-ATLPI, which is easier to use in clinical practice, achieved superior risk stratification compared to the ATLPI, as did the original m7-ATLPI; the simplified version was calculated by summing the following: high-risk ATL-PI category (+10), low-risk ATL-PI category (−4), and non-silent mutations in TP53 (+4), IRF4 (+3), RHOA (+1), PRKCB (+1), CARD11 (+0.5), CCR7 (−2), and GATA3 (−3).
The era of sustainable development and the challenge of climate change
Authors: Miró-Pérez Albert-P. , Bustelo Gracia José Luis
Published: February 2023

Sustainability makes it possible to understand that the human being is facing a world with exhaustible resources and limited needs, with a population in constant growth and with economic progress based on obsolete technologies that generate a huge energy consumption, apart from billions of tons of wastes added to the ecosystem. These factors unleash catastrophic climatic consequences that have put the “world” on alert when is understood that there is a limit of planetary support capacity and that we are approaching the collapse of the ecosystem and endangering future generations, in addition to undermining the quality of life of all living beings because they exceed the capacity for natural balance of the ecosystems that support it. The increase in poverty, the overproduction of waste, the enormous North-South differences, the desertification and climate change are some of the main factors that human beings must face with great urgency. Regarding this last factor, it should be noted that today it has become a problem of multidimensional proportions that involves governments, organizations and entire societies with the aim of reducing its catastrophic global consequences and has been categorized as one of the greatest challenges of the world in the 21st century. Damage to the environment is becoming an issue that has received greater interest and attention over the years. Therefore, it is necessary a construct that includes ecological and development perspectives, that is, Sustainable Development. Under this context, this article aims to analyse in detail this concept, its origins and evolution, as well as its dimensions, to also establish its link with climate change, both inseparable factors.
Pharmacological Management of Germinal Matrix-Intraventricular Hemorrhage
Authors: Chung Jaewoo , Lee Sang Koo , Cho Chun-Sung , Kim Young Jin , Ko Jung Ho , Yun Jung-Ho , So Jin-Shup , Jung In-Ho
Published: February 2023

Germinal matrix-intraventricular hemorrhage (GM-IVH) is among the devastating neurological complications with mortality and neurodevelopmental disability rates ranging from 14.7% to 44.7% in preterm infants. The medical techniques have improved throughout the years, as the morbidity-free survival rate of very-low-birth-weight infants has increased; however, the neonatal and long-term morbidity rates have not significantly improved. To this date, there is no strong evidence on pharmacological management on GM-IVH, due to the limitation of well-designed randomized controlled studies. However, recombinant human erythropoietin administration in preterm infants seems to be the only effective pharmacological management in limited situations. Hence, further high-quality collaborative research studies are warranted in the future to ensure better outcomes among preterm infants with GM-IVH.
PENDAMPINGAN PENINGKATAN KEMAMPUAN LITERASI DAN NUMERASI PADA SISWA SDN 1 MANGIR KECAMATAN ROGOJAMPI KABUPATEN BANYUWANGI
Authors: Prayitno Trio Ageng , Hidayati Nuril , Mushofi Yuskil , Mumpuni Kistantia Elok
Published: February 2023

Based on a joint agreement between the community service team and partners, in this case, SDN 1 Mangir, it is necessary to provide assistance to improve students' literacy and numeracy skills. The purpose of the service is to improve literacy and numeracy skills in SDN 1 Mangir students through mentoring activities. The methods used include observation, design, implementation, and evaluation. The place of service is held at SDN 1 Mangir. The service instrument used is in the form of observation sheets, reading interest rubrics in the Pojok Literasi, and tests of literacy and numeracy skills. The results of community service activities show that 1) partners respond positively to the implementation of community service activities, 2) the implementation of community service activities are in accordance with the achievement targets, and 3) literacy skills of 92.2% and numeration of 68.7%. Community service activities really help SDN 1 Mangir as a partner in improving students' literacy and numeracy skills.
Penanaman Nilai-Nilai Keagamaan di Raudhatul Athfal Al Falah 2 Danakerta
Authors: Suprihatin Suprihatin
Published: February 2023

This study aims to describe the implementation and methods used in instilling religious values ​​at RA Al Falah 2 Danakerta. This research is a qualitative descriptive study. The subjects of this study were homeroom teachers, madrasa heads and students of RA Al Falah 2 Danakerta. Data collection techniques in the form of observation, interviews and documentation. Data analysis techniques use the Miles & Huberman model: data reduction, data presentation, and reasoning. The results of the study show that: (1) The inculcation of religious values ​​at RA Al Falah 2 Danakerta is carried out through an activity management process which includes the Annual Program (PROTA), the Semester Program (PROSEM), The Weekly Learning Implementation Plan (RPPM) and the Daily Learning Implementation Plan (RPPH). The implementation of these activities includes opening activities, core activities, and closing activities. (2) The methods used in instilling religious values ​​at RA Al Falah 2 Danakerta include habituation methods, exemplary methods, demonstration methods, question and answer methods, play methods, storytelling methods, and field trip methods.
Aksi Perbaikan Mutu Sekolah terhadap Kedisiplinan Siswa melalui Pelaksanaan Tata Tertib di SMP Ma’arif 1 Kebumen
Authors: Nurhidayati Wiwit , Afiyyah Adyanil , Sarwiati Sarwiati , Fatimatul Nurroniyah , Hidayat Sukron
Published: February 2023

Improving the quality of schools must always be carried out continuously in order to achieve educational goals. However, schools often ignore the little things that actually really support efforts to improve school quality, such as school rules. This study aims to find problems related to school quality improvement, determine quality improvement work priorities, carry out school quality improvement action activities, and reflect on the importance of school quality improvement through action. Location of activities at SMP Ma’arif 1 Kebumen. The management theory used is the plan-do-check-act (PDCA) model. Data collection techniques were through problem mapping, determining work priorities, implementing actions, and reflecting, which were carried out with partners in a participatory manner with the Deputy Head of Student Affairs, the Student Council Teacher, and the Student Council of Middle School Maarif 1 Kebumen. The results were (a) a number of problems related to school quality were found, (b) disciplinary work priorities were determined through the implementation of school rules, (c) socialization was held with action partners, (d) actions were held in the form of controlling school rules and student discipline, (e the reflection is that the partners realize the importance of school rules and at the same time their implementation is carried out together.
Pengaruh Lingkungan Keluarga Terhadap Kedisiplinan Siswa pada Pembelajaran PAI di MI
Authors: Khoeriyah Faizatul
Published: February 2023

In the educational process, generally a discipline must be owned by every student because with discipline a person can increase his ability to protect himself from something that causes confusion. Discipline cultivation must be done early. If discipline is instilled in the family environment from an early age, they will make it a habit and part of themselves. The level of discipline of each student is different, depending on how parents provide guidance to their children and how education is in their family environment. This study aims to examine in depth the influence of the family environment on student discipline. This type of research is field research using a quantitative approach and taking the subjects of MI Salafiyah Tanjung students. There is a population of 276 students and the sample is 45 students out of 6 (purposive sampling). The data were collected using a Likert scale questionnaire statement. The results of the data are processed through statistical calculations from preliminary analysis, prerequisite tests, and hypothesis testing using SPSS V.26. Obtained very high family environment data of 68.13, very high student discipline of 72.51, and R Square results of 39.1%. Overall, it can be seen from the acquisition of R Square results of 39.1% which means that there is a family influence on student discipline of 39.1% and 60.9 is influenced by other variables.
Primary Paraganglioma of the Thyroid Gland: Clinical and Immunohistological Analysis with a Literature Review
Authors: Feghaly Julien , Astras George , Loizou Marios , Panayiotou Giannis , Mooradian Ariana
Published: February 2023

Primary paraganglioma of the thyroid is a rare neuroendocrine tumour, often mistaken for other thyroid neoplasms. Here, we describe a case of initially misdiagnosed primary paraganglioma of the thyroid and study its clinical presentation, management, investigation, and immunohistological findings.

A 72-year-old male presented with a left-sided solitary thyroid lobe and isthmus nodule. Ultrasound, fine needle aspiration, and computed tomography did not provide a clear diagnosis and subsequently, a left lobectomy and isthmusectomy were performed. The initial histopathological findings of the tumour revealed positivity to chromogranin and calcitonin, suggesting a medullary carcinoma replacing the left lobe of the thyroid. In a second histopathological review at an external laboratory, the tumour cells showed positive focal staining for chromogranin, but were negative for both calcitonin and monoclonal carcinoembryonic antigen, suggesting thyroid paraganglioma. This case highlights the importance of accurate histopathological diagnosis and the need to be aware of the possibility of thyroid paraganglioma initially presenting as a thyroid nodule.
Optimising Cancer Immunotherapy: Challenges and Opportunities
Authors: Grenon Stoddert Trudy
Published: February 2023

Cancer immunotherapy has moved to the forefront in the treatment of patients with cancer, providing a unique opportunity to achieve dramatic and lasting anti-tumour responses in a variety of tumour types. When it comes to patient selection and development of novel immunotherapeutic agents and combinations, so far we have merely scratched the surface of this therapeutic approach. Leading experts in the field of cancer immunotherapy gathered in Amsterdam, Netherlands, on 21st May 2016 for a Scientific Exchange to discuss the current status of immunotherapy within the field of oncology and explore the future of this evolving therapeutic strategy. Current challenges and limitations regarding the use of immunotherapy were addressed for tumour types such as melanoma, lung cancer, bladder cancer, and renal cell carcinoma (RCC). Recent advances and future directions in the areas of immunotherapy biomarkers and mechanisms of resistance were also examined. Current evidence for combination strategies with immunotherapy was highlighted, including combinations with other immunotherapies or with radiotherapy. Below is a summary of the key points discussed during this scientific exchange.
Management of Refractory Lupus Nephritis
Authors: Fanouriakis Antonis , Bertsias George
Published: February 2023

Despite the significant advances in the field, up to one-third of lupus nephritis (LN) patients still do not respond adequately to initial immunosuppressive treatment. This group of patients is heterogeneous in terms of clinical presentation (deterioration of glomerular filtration rate, variable degrees of persistent proteinuria, active urine sediment) and the potential for reversion (ongoing kidney inflammation versus irreversible damage due to scarring and fibrosis). A repeat kidney biopsy can be highly informative in this regard and should be strongly considered. High-quality evidence regarding the treatment of refractory LN is lacking, and management is largely based on observational studies and expert opinion. Options include switching between mycophenolate mofetil (MMF) and cyclophosphamide (CYC), using rituximab as monotherapy or add-on therapy, or combining MMF with a calcineurin inhibitor in cases of persistent proteinuria. Renal response can be maintained with MMF or prolonged pulses of intravenous CYC administered bimonthly or quarterly. The efficacy of novel biological agents and those under development in refractory forms of LN remains to be determined. Tight control of cardiovascular risk factors, use of hydroxychloroquine, immunisations, and osteoporosis prophylaxis are important adjunctive measures. For the future, we anticipate that research efforts for the identification of accurate biomarkers together with accumulating data from observational and controlled studies will assist therapeutic decisions and improve outcomes in patients with refractory LN.
Cabozantinib Versus Everolimus in Patients with Advanced Renal Cell Carcinoma: Results of a Randomised Phase III Trial (METEOR)
Authors: Smithers Lucy
Published: February 2023

The METEOR trial of cabozantinib versus everolimus in advanced renal cell carcinoma (RCC) was reported by Prof Choueiri at the European Cancer Congress 2015. This presentation follows the publication in the New England Journal of Medicine of the METEOR trial back-to-back with the CheckMate 025 trial of nivolumab versus everolimus in the same patient setting. Excitingly, these trials demonstrated, for the first time, significant benefits over the standard of care for heavily pre-treated patients with advanced RCC. Cabozantinib, an oral multi-targeted tyrosine kinase inhibitor (TKI) aims to address the challenge of resistance to targeted therapy with TKIs. While the METEOR trial has not yet reached its final analysis of overall survival (OS), the clear progression-free survival (PFS) benefit, acceptable safety profile, and similar tolerability to other TKIs shown by cabozantinib indicate that this represents a promising new treatment option for second-line or subsequent therapy for patients with advanced RCC.
Current and Future Developments in the Treatment of CD30+ Lymphomas
Authors: Specht Lena , Gisselbrecht Christian
Published: February 2023

CD30 is a cell membrane protein expressed on the surface of a range of lymphomas, which has important diagnostic, pathogenic, and prognostic roles. The most common CD30+lymphomas are Hodgkin’s lymphoma (HL) and anaplastic large cell lymphoma (ALCL), but other types of lymphoma also express CD30, although less frequently. Attempts to develop a monoclonal antibody therapy that targets CD30 were initially unsuccessful, but recent Phase I and II trials have shown promising results from the use of the immune conjugate brentuximab vedotin in HL and ALCL. Phase III trials are ongoing to evaluate clearly the benefit–risk ratio when compared with standard treatment. The first of these to report preliminary findings, the AETHERA trial, showed improved progression-free survival times in relapsing/refractory HL patients treated with brentuximab vedotin as a consolidation therapy after autologous stem cell transplantation compared with those receiving placebo. Patients with rarer CD30+ lymphomas may also benefit from brentuximab vedotin therapy in the future. Moreover, combination treatment with immunomodulatory and cell cycle checkpoint modulators that are currently under development, as well as conventional chemotherapeutic agents, may yield further benefits. To this end, improved methods of CD30 detection and quantitation will improve the delineation of non-HL subtypes in which CD30-targeted therapy may be clinically indicated.
Intelligent Application of Breast Cancer Trials Data in the Clinic
Authors: Tomlinson Heather
Published: February 2023

This meeting commenced with a talk from Prof Loibl on neoadjuvant and adjuvant strategies for HER2positive (human epidermal growth factor receptor 2-positive) early breast cancer (EBC), which featured a précis on the most pertinent, recent trial data and how these data may shape future treatment decisions in clinical practice. Prof Conte moved the discussion forward by addressing how recent studies may lead towards a new standard of care (SoC) and treatment paradigms in patients with metastatic breast cancer. Prof Schmid gave an overview of potential strategies that could be used to prevent or overcome endocrine therapy resistance in patients with hormone receptor-positive breast cancer. The session was concluded with a presentation on ‘Precision Medicine for Metastatic Breast Cancer’ by Prof Sotiriou, in which he highlighted the potential applications of precision medicine and some of the different approaches that have been used in metastatic breast cancer. Prof Verma, the meeting chair, opened the symposium and facilitated the discussion sessions. The contents of the presentations and discussions are summarised herein.
Interactive multimedia development in opportunity competence using macromedia flash
Authors: Ferita Rolina Amriyanti , Wahyuningsih Endang
Published: February 2023

This study aims to produce an interactive multimedia on opportunity competencies using macromedia flash. This development research used the ADDIE design, which was carried out at SMA Negeri 5 Yogyakarta, and the research subjects were media experts, material experts, mathematics teachers and class XI students at SMA Negeri 5 Yogyakarta. Data collection instruments used validation sheets, evaluation sheets, and response questionnaires. The validation sheet is used for two validator lecturers. Evaluation sheets for media experts, material experts, teachers, and students. The response questionnaire for students. Quantitative data from Likert scale evaluation sheets (1-4) are calculated on average and then converted into five categories from very bad to very good, while qualitative data from student response questionnaires are scored according to their level and then the average is calculated then also converted into five category. The results showed that the interactive multimedia developed was in the good category, obtained from the media expert's evaluation sheet score of 3.06, material expert's score of 3.31, teacher's average score of 3.26, and student's average score of 3.12. The results of the student response questionnaire fall into the good category with an average score of 3.04.
Pertumbuhan Rajungan (Portunus pelagicus) Yang Diberi Pakan Segar Keong Bakau (Telescopium telescopium) Dan Keong Mas (Pomacea canaliculata) Dalam Sistem Resirkulasi
Authors: Rahmawati Rahmawati , Rahman Abdul
Published: February 2023

Rajungan (Portunus pelagicus) merupakan komoditas ekspor yang bernilai cukup tinggi sehingga teknologi pembudidayaannya yang berkelanjutan seperti kontinyuitas pakannya sangat perlu dikembangkan. Penelitian ini bertujuan mengetahui pengaruh pakan segar keong bakau dan keong mas dalam pemanfaatan sumber pakan pada budidaya rajungan dengan media sistem resirkulasi. Penelitian menggunakan rancangan acak kelompok (RAK) dengan 3 perlakuan dan 3 kelompok ulangan. Perlakuan berupa pakan segar keong bakau (Pakan A), keong mas (Pakan B) dan kombinasi pakan keong bakau+keong mas (Pakan C) yang diberikan selama 42 hari pemeliharaan. Parameter yang diamati adalah laju pertumbuhan spesifik (LPS), pertumbuhan mutlak (PM), panjang karapas (PK), lebar karapas (LK) dan kelangsungan hidup (SR). Hasil penelitian menunjukkan bahwa nilai rata-rata LPS berkisar antara 1,10-1,36%, PM 6,69-8,89 g, PK 0,25-0,53 cm, LK 0,97-1,28 cm dan SR 33,33-46,67%. Hasil analisis sidik ragam pada parameter terukur tersebut bahwa pakan segar keong bakau dan pakan segar kombinasi keong bakau+mas tidak berbeda nyata namun keduanya berbeda nyata dengan pakan segar keong mas terhadap LPS, PM, dan LK, sedangkan terhadap PK dan SR tidak berbeda nyata. Tingkat kesukaan terhadap jenis makanan dan kandungan nutrisi masing-masing pakan uji menjadi penyebab perbedaan hasil analisis parameter biologi rajungan pada kedua jenis pakan segar tersebut. Pakan kombinasi kedua jenis pakan segar sangat potensial mendukung  pengembangan budidaya rajungan dalam wadah dengan sistem resirkulasi.Kata kunci : pakan segar, keong bakau, keong mas, Portunus pelagicus,, resirkulasi.
Pengaruh Penambahan Alginat Dalam Pakan Terhadap Performa Pertumbuhan Dan Efisiensi Pemanfaatan Pakan Udang Vannamei (Litopenaeus vannamei)
Authors: Mudiarti Luky , Setiyowati Desti , Kursistiyanto Nurcahyo , Alimin Noor
Published: February 2023

Penelitian bertujuan untuk mengetahui pengaruh suplementasi ekstrak alginat terhadap tingkat konsumsi pakan, efisiensipemanfaatan pakan, pertumbuhan mutlak dan laju pertumbuhan spesifik udang vaname. Rancangan digunakan dalampenelitian yaitu rancangan acak lengkap dengan 3 perlakuan dan 3 ulangan. Perlakuan yang diterapkan (A) 0 gAlginat/kg pakan, (B) 1 g Alginat/kg pakan (C) 2 g Alginat/kg pakan. Masing-masing pakan uji ditambahkanmultivitamin 1 g/kg pakan dan progol 2 g/kg pakan. Udang vaname (L. vannamei) digunakan berukuran 10 g ± 0,5 g,padat tebar 15 ekor/150 l dalam wadah kontainer volume 200 l. Kegiatan penelitian dilakukan selama 35 hari. Pakandiberikan sebanyak 5% biomassa udang vaname. Pakan diberikan sebanyak 4 kali. Parameter yang diamati meliputisuhu, pH, DO, salinitas, TKP, SGR dan EPP. Analisis uji statistik menggunakan one way anova dan uji lanjut tukey.Hasil penelitian menunjukkan bahwa kualitas air masih dalam rentang optimal. Hasil uji statistik yang didapatkan padasaat penelitian menunjukkan bahwa pemberian pakan yang di suplementasi alginat berbeda konsentrasi berpengaruhnyata (P<0,05) terhadap tingkat konsumsi pakan (TKP), laju pertumbuhan spesifik (SGR) dan efisiensi pemanfaatanpakan (EPP). Perlakuan C dengan dosis alginat (2 g/kg pakan) merupakan dosis terbaik untuk TKP, SGR dan EPP udangvaname.Kata Kunci: Pakan; alginate; udang vaname (L. vannamei); pertumbuhan
Pengaruh Rotasi Harian Menu Jenis Pakan Terhadap Kinerja Pertumbuhan Dan Kelangsungan Hidup Ikan Lele Sangkuriang Clarias gariepinus, Burchell 1822)
Authors: Husni Muhammad , Sabilu Kadir , Rahman Abdul
Published: February 2023

ABSTRAK Perubahan strategi pemberian pakan dengan variasi menu pakan harian yang memanfaatkan jenis pakan yang lebih murah diharapkan dapat menekan biaya pakan pada sistem produksi Clarias gariepinus. Penelitian ini bertujuan mengetahui pengaruh variasi harian menu jenis pakan menggunakan pellet dan usus ayam terhadap kinerja pertumbuhan Clarias gariepinus. Penelitian terdiri atas 4 perlakuan, yaitu: menggunakan pakan pellet setiap hari (A); penggunaan pakan pelet dan pakan usus ayam secara bergantian setiap hari (B); penggunaan pakan pelet selama 2 hari, dilanjutkan dengan pakan usus ayam selama 1 hari (C), dan pemberian pakan usus ayam setiap hari (D). Ikan lele diberi makan 2 kali sehari, yaitu jam 08.00 pagi dan jam 16.00 Wita. Hasil penelitian menunjukkan bahwa setelah 45 hari pemeliharaan, kelangsungan hidup ikan lele pada semua perlakuan tidak berbeda nyata. Pertumbuhan mutlak, laju pertumbuhan spesifik dan retensi protein ikan lele yang diberi pakan pelet dan pakan usus ayam secara bergantian setiap hari tidak berbeda nyata dengan perlakuan C (pakan pelet selama 2 hari, dilanjutkan pakan usus ayam selama 1 hari). Respon LPS, PM dan RP ikan lele pada kedua perlakuan tersebut signifikan lebih tinggi dibandingkan dengan ikan lele yang diberi pakan usus ayan setiap hari, tetapi keduanya signifikan lebih rendah dibandingkan LPS, PM dan RP ikan lele yang diberi makan menggunakan pellet setiap hari. Dengan demikian, pemberian pakan menggunakan pakan pelet dan pakan usus ayam yang diberikan secara bergantian setiap hari atau pemberian pakan pelet setiap 2 hari sekali dapat dipertimbangkan untuk diterapkan pada usaha budidaya ikan lele pada ukuran awal bibit 15-45 gr. Kata Kunci: Ikan lele, pakan pellet, pakan usus ayam, pertumbuhan, dan menu pakan harian
Fostering Citizenship Skills with Kritik in the Undergraduate Classroom
Authors: McCurdy Karen , Lubecki Jacek
Published: February 2023

Citizen Engagement is a skill that people learn from others. This paper focuses on the use of a new pedagogical software product that helps increase the amount and quality of student writing. We present a detailed explanation of two distinct ways of using the Kritik software. The authors implemented a new pedagogical tool, Kritik, in several of our courses during academic year 2021-2022, and in fall 2022. We are reporting preliminary results of our experience with this software in Face to Face, software supported courses. Our preliminary assessment is that that Kritik is a useful tool in many Face to Face political science classroom environments. With Kritik students write more, construct better arguments, and gain experience in peer evaluation. We expect these skills will better prepare students for effective civil discourse, and they will better understand decision making in the policy process and the complexity of citizen engagement.
The Theory of Democratic Voice Expression
Authors: Falvey Denis
Published: February 2023

This paper is a Euclidean presentation of democratic voice expression theory, with a few significant illustrative applications.
Spelet om kommunstrukturen
Authors: Erlingsson Gissur Ó
Published: February 2023

Under 1990-talets mitt, när jag studerade freds- och konfliktkunskap, var mina kurskamrater intresserade av inbördeskrig och mellanstatliga konflikter...