bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Table and Figure Legends from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Authors: Zhu Jieqing , Xiong Gaofeng , Fu Hanjiang , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: March 2023

Supplemental Table and Figure Legends. Legends for Supplemental Table S1 and Supplemental Figures S1-S4.
Supplementary Figure S3 from Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
Authors: Emir Uzay E. , Larkin Sarah J. , de Pennington Nick , Voets Natalie , Plaha Puneet , Stacey Richard , Al-Qahtani Khalid , Mccullagh James , Schofield Christopher J. , Clare Stuart , Jezzard Peter , Cadoux-Hudson Tom , Ansorge Olaf
Published: March 2023

2-hydroxyglutarate (2-HG), Glycine (Gly) and Lactate (Lac) detection by semi-LASER at 7T.
Supplemental Figure S4 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Authors: Zhu Jieqing , Xiong Gaofeng , Fu Hanjiang , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: March 2023

Supplemental Figure S4. Increased Hsp47 expression has been detected in ER negative cancer and is negatively associated with GATA3 levels.
Supplementary Figure Legends from Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
Authors: Emir Uzay E. , Larkin Sarah J. , de Pennington Nick , Voets Natalie , Plaha Puneet , Stacey Richard , Al-Qahtani Khalid , Mccullagh James , Schofield Christopher J. , Clare Stuart , Jezzard Peter , Cadoux-Hudson Tom , Ansorge Olaf
Published: March 2023

Legends for Supplementary Figures S1-S5.
Supplementary Tables S1-S12 from Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma
Authors: Phan Liem M. , Fuentes-Mattei Enrique , Wu Weixin , Velazquez-Torres Guermarie , Sircar Kanishka , Wood Christopher G. , Hai Tao , Jimenez Camilo , Cote Gilbert J. , Ozsari Levent , Hofmann Marie-Claude , Zheng Siyuan , Verhaak Roeland , Pagliaro Lance , Cortez Maria Angelica , Lee Mong-Hong , Yeung Sai-Ching J. , Habra Mouhammed Amir
Published: March 2023

Basic patients characteristics of the cohort used for serum HGF measurements ; Patients characteristics of second TMA ; Genes with significantly (P {less than or equal to} 0.05, absolute value of log ratio > 0.1) changed expression in tumors from ACC patients (dataset GSE10927) relative to expression in normal adrenocortical tissues ; Biological processes Significantly (P<0.05) changed in tumors from ACC patients with high MET expression relative to tumors with low MET expression (dataset GSE10927) as presented in Figure 2a ; Genes significantly (P {less than or equal to} 0.05, absolute value of log ratio > 0.1) changed in tumors from ACC patients with high MET expression compared to those with low MET expression (dataset GSE10927) ; Gene set enrichment analysis of ACC patients' cohort for genes related to cell proliferation (dataset GSE10927) ; Gene set enrichment analysis of ACC patients' cohort for genes related to the negative regulation of cell apoptosis (dataset GSE10927) ; Gene set enrichment analysis of ACC patients' cohort for genes related to cell proliferation (dataset GSEA49278) ; Gene set enrichment analysis of ACC patients' cohort for genes related to the negative regulation of cell apoptosis (dataset GSEA49278) ; Drug metabolism-related genes with significantly (P {less than or equal to} 0.05, absolute value of log ratio > 0.1) changed expression in tumors from ACC patients (dataset GSE10927) with high MET expression relative to those with low MET expression ; Gene set enrichment analysis detail of ACC patients' cohort for genes associated with resistance and metabolism of cisplatin, etoposide and doxorubicin (dataset GSEA10927) ; Gene set enrichment analysis detail of ACC patients' cohort for genes associated with resistance and metabolism of cisplatin, etoposide and doxorubicin (dataset GSEA49278) .
Table S4. Key genes involved with anti-proteasomal response in L428 cells. from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: March 2023

These key genes were determined by finding the common genes between the significant upstream regulators, biofunction analysis, and Gene Set Enrichment Analysis (GSEA) for GO gene sets with a FDR < 0.05 for ixazomib 25nM/24 hours vs. Control for L428 cells. The second column denotes the effects these genes have on tumor progression based on the literature. Genes with no reported effects on tumors were identified as Not Determined (ND).
Supplementary Figures S1-S6 from Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma
Authors: Phan Liem M. , Fuentes-Mattei Enrique , Wu Weixin , Velazquez-Torres Guermarie , Sircar Kanishka , Wood Christopher G. , Hai Tao , Jimenez Camilo , Cote Gilbert J. , Ozsari Levent , Hofmann Marie-Claude , Zheng Siyuan , Verhaak Roeland , Pagliaro Lance , Cortez Maria Angelica , Lee Mong-Hong , Yeung Sai-Ching J. , Habra Mouhammed Amir
Published: March 2023

High MET expression in ACC patients (S1); High MET mRNA expression levels in ACC (S2); cMET signaling is activated in ACC (S3); Increased HGF/cMET signaling is associated with enhanced proliferation and reduced apoptosis in tumors from ACC patients (S4); HGF stimulates NCI-H295R ACC cell proliferation (S5); HGF/cMET signaling is important for ACC cell energy metabolism (S6).
Supplementary Legends from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: March 2023

Legends for Figure S1, S2 and S3
Figure S3. Inhibition of histone acetyl transferase (HAT). from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: March 2023

Inhibition of HAT with C646 resulted in decreased histone acetylation and Myc expression in L428 (HL) and Jurkat (TCL) cells on Western blot.
Figure S2. Network representation of Gene Set Enrichment Analysis (GSEA) for Biological pathways. from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: March 2023

A. Reactome, B. KEGG, C. MYC Pathways, extract from C2 gene sets for ixazomib 24 hours versus control for Jurkat, L540, and L428 cells, with L540 overlaid with either Jurkat or L428. Leading edge analysis with a FDR<0.05 determined significant gene sets enriched for each group. The size of each node reflects the amount of molecules involved for each gene set. The edge thickness (green lines for L540 and blue lines for either Jurkat or L428) represents the number of genes associated with the overlap of two gene sets (or nodes) that the edge connects. Clusters in each grouping were named according to common function. Upregulated gene sets denoted with red color and downregulated gene sets were denoted by blue color.
Supplemental Table 1 from A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Authors: Heilmann Silja , Ratnakumar Kajan , Langdon Erin M. , Kansler Emily R. , Kim Isabella S. , Campbell Nathaniel R. , Perry Elizabeth B. , McMahon Amy J. , Kaufman Charles K. , van Rooijen Ellen , Lee William , Iacobuzio-Donahue Christine A. , Hynes Richard O. , Zon Leonard I. , Xavier Joao B. , White Richard M.
Published: March 2023

Supplemental Table 1. This is data on the number of attempted zebrafish cell lines and our success rates in terms of long term propagation and weaning off fibronectin.
Supplemental Figures 1-20 from A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Authors: Heilmann Silja , Ratnakumar Kajan , Langdon Erin M. , Kansler Emily R. , Kim Isabella S. , Campbell Nathaniel R. , Perry Elizabeth B. , McMahon Amy J. , Kaufman Charles K. , van Rooijen Ellen , Lee William , Iacobuzio-Donahue Christine A. , Hynes Richard O. , Zon Leonard I. , Xavier Joao B. , White Richard M.
Published: March 2023

Supplemental Figures 1-20. Supplemental Figure 1: Metastatic behavior of primary melanoma transplants. Supplemental Figure 2: Demonstration of cDNA overexpression in the ZMEL1 line. Supplemental Figure 3: Demonstration of CRISPR/Cas9-mediated mutation in the ZMEL1 line. Supplemental Figure 4: SURVEYOR assay to assess mutation rates in ZMEL1 cells nucleofected with CRISPR/Cas9 constructs. Supplemental Figure 5: Gene Set Enrichment Analysis (GSEA) for the ZMEL1 transcriptional signature compared to the NCI60 human cancer cell lines (dataset NCI60GSE5846). Supplemental Figure 6: Heatmap plot of the ZMEL1 transcriptional signature compared to the NCI60 human cancer cell lines (dataset NCI60GSE5846). Supplemental Figure 7: Gene Set Enrichment Analysis (GSEA) for the ZMEL1 compared to transgenic mitf-BRAF;p53 tumors. Supplemental Figure 8: Heatmap plot of the ZMEL1 transcriptional signature compared to transgenic mitf-BRAF;p53 tumors. Supplemental Figure 9: Ingenuity Pathway Analysis of the ZMEL1 expression signature showing canonical pathways. Supplemental Figure 10: Ingenuity Pathway Analysis of the ZMEL1 expression signature showing core enriched networks. Supplemental Figure 11: Heatmap of metastatic spread over 14 days when cells are transplanted dorsally. Supplemental Figure 12: Histologic assessment of fish transplanted with ZMEL1-GFP cells Supplemental Figure 13: Histology of the kidney marrow from a stable transgenic mitfa-BRAFV600E;p53-/- melanoma bearing fish. Supplemental Figure 14: Derivation of the µ score for quantifying metastatic burden Supplemental Figure 15: Calculation of the metastasis initiating cell (MIC) frequency Supplemental Figure 16: Schematic overview of bright field image processing. Supplemental Figure 17: Determining pixel intensities in the transformed images. Supplemental Figure 18: Methods for segmentation of GFP images. Supplemental Figure 19: Methods for clustering of close objects. Supplemental Figure 20: Methods for separating merged tumors/metastases.
Supplementary Figures S1-S5 and Tables S1-S3 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: March 2023

Supplementary Figure S1. TGF beta remodels the ECM generated by mesenchymal stem and 1BR3G cells in a Snail1-dependent manner. Supplementary Figure S2. Cell Commitment is Modulated by Fibroblast-derived Matrices in a Snail1-dependent Manner. Supplementary Figure S3. TGF beta controls focal contacts in a Snail1-dependent manner. Supplementary Figure S4. TGF beta regulates N-cadherin intercellular contacts in a Snail1-dependent manner. Supplementary Figure S5. Alignment of MEFs bo-cultured with CAFs. Supplementary Table S1. Baseline Characteristics According to Snail1 Expression in the Stroma Supplementary Table S2. Overall Survival Analysis in Patients with Snail1 Expression in Stroma Supplementary Table S3. Antibodies Used for Protein Analysis
Supplemental Figure S2 from PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment
Authors: Li Jing , Jie Hyun-Bae , Lei Yu , Gildener-Leapman Neil , Trivedi Sumita , Green Tony , Kane Lawrence P. , Ferris Robert L.
Published: March 2023

Supplemental Figure S2. PD-1 ligation with bead-coated PD-L1 suppresses p-STAT1 and Tbet upon TCR stimulation, while anti-PD-1 blockade could reverse the suppressive effects of PD-1.
Supplementary Figure 1 from Genetic Mutation of p53 and Suppression of the miR-17∼92 Cluster Are Synthetic Lethal in Non–Small Cell Lung Cancer due to Upregulation of Vitamin D Signaling
Authors: Borkowski Robert , Du Liqin , Zhao Zhenze , McMillan Elizabeth , Kosti Adam , Yang Chin-Rang , Suraokar Milind , Wistuba Ignacio I. , Gazdar Adi F. , Minna John D. , White Michael A. , Pertsemlidis Alexander
Published: March 2023

Supplementary Figure 1. Activity of miR-92a related inhibitors.
Supplementary Figure S6 from Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease
Authors: Taipaleenmäki Hanna , Browne Gillian , Akech Jacqueline , Zustin Jozef , van Wijnen Andre J. , Stein Janet L. , Hesse Eric , Stein Gary S. , Lian Jane B.
Published: March 2023

Supplementary Figure S6. Localization of miR-135 and miR-203 binding sites within the human Runx2 3'UTR.
Supplementary Figures S1-S22 from Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer
Authors: Peng Jin , Hamanishi Junzo , Matsumura Noriomi , Abiko Kaoru , Murat Kumuruz , Baba Tsukasa , Yamaguchi Ken , Horikawa Naoki , Hosoe Yuko , Murphy Susan K. , Konishi Ikuo , Mandai Masaki
Published: March 2023

Upregulation of NF-κB p65 in mouse ovarian cancer cell lines following treatment with chemotherapeutic agents (S1); NF-κB p65 and PD-L1 expression in mouse ovarian cancer cell lines after chemotherapeutic agents (S2); NF-κB p65, PD-L1 and MHC expression in human ovarian cancer cell lines after Gemcitabine or Paclitaxel (S3); Upregulation of MHC class I in ovarian cancer cell lines following treatment with chemotherapeutic agents (S4); Upregulation of PD-L1 mRNA expression in microarray dataset GSE18728 (S5); Upregulation of PD-L1 in mouse ovarian cancer cell lines following chemotherapeutic treatment in vitro (S6); Upregulation of PD-L1 in human ovarian cancer cell lines following chemotherapeutic treatment in vitro (S7); Generation of NF-κB p65 knockdown mouse ovarian cancer cells with shNF-κB p65 (S8); Chemotherapeutic agents upregulate MHC class I via NF-κB in mouse ovarian cancer cell lines in vitro (S9); Chemotherapeutic agents upregulate MHC class I and PD-L1 via NF-κB in human ovarian cancer cell lines in vitro (S10); PD-L1 was enhanced by Gemcitabine or paclitaxel via NF-kB signal in human ovarian cancer cell lines (S11); Chemotherapeutic agents upregulate PD-L1 via NF-κB in mouse ovarian cancer cell lines in vitro (S12); PD-L1 was enhanced by Gemcitabine or paclitaxel via NF-kB signal in mouse ovarian cancer cell lines (S13); PD-L1 was enhanced by Gemcitabine or paclitaxel via NF-kB signal in human ovarian cancer cell lines (S14); Knockdown of Ifngr1 expression in ID8 cells (S15); PD-L1 expression is upregulated by Gemcitabine or paclitaxel in the absence of the IFN-γ signaling pathway (S16); The effect of chemotherapeutic drugs on the immunological microenvironment of mouse tumor tissue (S17); Expression of PD-L1 and NF-κB p65 in ID8MirControl, ID8Mirpdl1, or ID8pdl1 cells incubated with GEM or PTX (S18); Chemotherapeutic drugs combined with PD-L1/PD-1 signaling blockade treatment in mouse model (S19); Generation of ID8OVA cells (S20); Anti-PD-1 antibody enhances the immune activation effect of PTX in a mouse ovarian cancer model (S21); The effect of GEM and PTX on Gr-1+ MDSCs (S22).
Supplementary Figure S1 from Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease
Authors: Taipaleenmäki Hanna , Browne Gillian , Akech Jacqueline , Zustin Jozef , van Wijnen Andre J. , Stein Janet L. , Hesse Eric , Stein Gary S. , Lian Jane B.
Published: March 2023

Supplementary Figure S1. Runx2 and Smad5 expression in primary breast tumors.
Supplementary Figure Legends from Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease
Authors: Taipaleenmäki Hanna , Browne Gillian , Akech Jacqueline , Zustin Jozef , van Wijnen Andre J. , Stein Janet L. , Hesse Eric , Stein Gary S. , Lian Jane B.
Published: March 2023

Supplementary Figure Legends. Legends for Supplementary Figures S1-S7.
Supplementary figure 4 from Ceacam1L Modulates STAT3 Signaling to Control the Proliferation of Glioblastoma-Initiating Cells
Authors: Kaneko Sadahiro , Nakatani Yuka , Takezaki Tatsuya , Hide Takuichiro , Yamashita Daisuke , Ohtsu Naoki , Ohnishi Takanori , Terasaka Shunsuke , Houkin Kiyohiro , Kondo Toru
Published: March 2023

Supplementary figure 4. Overexpression of ceacam1L kept the neurosphere formation activity of hGICs
Supplemental Figure 2 from Tumor Radiosensitization by Monomethyl Auristatin E: Mechanism of Action and Targeted Delivery
Authors: Buckel Lisa , Savariar Elamprakash N. , Crisp Jessica L. , Jones Karra A. , Hicks Angel M. , Scanderbeg Daniel J. , Nguyen Quyen T. , Sicklick Jason K. , Lowy Andrew M. , Tsien Roger Y. , Advani Sunil J.
Published: March 2023

MMAE enhances γH2Ax foci formation following irradiation.
Supplemental Figure 1 from Tumor Radiosensitization by Monomethyl Auristatin E: Mechanism of Action and Targeted Delivery
Authors: Buckel Lisa , Savariar Elamprakash N. , Crisp Jessica L. , Jones Karra A. , Hicks Angel M. , Scanderbeg Daniel J. , Nguyen Quyen T. , Sicklick Jason K. , Lowy Andrew M. , Tsien Roger Y. , Advani Sunil J.
Published: March 2023

MMAE enhances comet tail length following irradiation in pancreatic tumor cell lines.
Supplementary Materials from Ceacam1L Modulates STAT3 Signaling to Control the Proliferation of Glioblastoma-Initiating Cells
Authors: Kaneko Sadahiro , Nakatani Yuka , Takezaki Tatsuya , Hide Takuichiro , Yamashita Daisuke , Ohtsu Naoki , Ohnishi Takanori , Terasaka Shunsuke , Houkin Kiyohiro , Kondo Toru
Published: March 2023

Supplementary materials & methods and supplementary figure legends
Supplementary Table S8 from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: March 2023

Output of genome-scale shRNA screen in HKO1.
Supplementary Table S2 from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: March 2023

Primers used for amplification and Illumina® sequencing of genomic DNA samples from shRNA screens.
Supplementary Table S1 from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: March 2023

Suppliers of cell lines and composition of cell culture media.
Supplementary Methods and References from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figures S1-S14 from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: March 2023

Evaluation of SN30000-induced bystander cell killing in a co-culture system (S1); SN30000 clonogenic survival curves for HT-29, PANC-1 cells and HKO1 (S2); Plating efficiency in HT-29, PANC-1 and HKO2 reductase screens (S3); Density distributions and correlations of reductase screen sequencing data (S4); Log2 enrichment factors of shRNAs significantly selected in the reductase screens (S5); Depletion of POR protein by shRNAs in PANC-1 and HT-29 cells (S6); Replicate SN30000 clonogenic survival assays performed in stably transduced HT-29 and PANC-1 cells (S7); Measurement of plating efficiency in HKO1 and HKO2 whole-genome screens (S8); Coincidence of shRNAs significantly selected (Z > 1.96) in HT-29 and PANC-1 reductase screens and the HKO1 genome-wide screen (S9); Validation of POR shRNAs and clonogenic survival following SN30000 treatment of POR-knockout HCT116 cells (S10); Spatial distribution of POR and CA-IX expression in tongue SCC (S11); Quantitation of POR and CA-IX expression in HNSCC (S12); POR IHC staining in isogenic xenografts used for method development (S13); POR mRNA expression and sequence variation in the TCGA HNSCC dataset (S14).
Supplemental material from Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry
Authors: Guenther Sabine , Muirhead Laura J. , Speller Abigail V.M. , Golf Ottmar , Strittmatter Nicole , Ramakrishnan Rathi , Goldin Robert D. , Jones Emrys , Veselkov Kirill , Nicholson Jeremy , Darzi Ara , Takats Zoltan
Published: March 2023

Supplemental material on model generation and data handling
Supplemental Table S6 from Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
Authors: Neskey David M. , Osman Abdullah A. , Ow Thomas J. , Katsonis Panagiotis , McDonald Thomas , Hicks Stephanie C. , Hsu Teng-Kuei , Pickering Curtis R. , Ward Alexandra , Patel Ameeta , Yordy John S. , Skinner Heath D. , Giri Uma , Sano Daisuke , Story Michael D. , Beadle Beth M. , El-Naggar Adel K. , Kies Merrill S. , William William N. , Caulin Carlos , Frederick Mitchell , Kimmel Marek , Myers Jeffrey N. , Lichtarge Olivier
Published: March 2023

Supplemental Table S6. Stratification of TP53 mutations by either disruptive or truncating systems in the validation set did not identify a subset of mutations associated with decreased overall survival, disease free survival, or time to distant metastases.
Supplemental Figure 1 from Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry
Authors: Guenther Sabine , Muirhead Laura J. , Speller Abigail V.M. , Golf Ottmar , Strittmatter Nicole , Ramakrishnan Rathi , Goldin Robert D. , Jones Emrys , Veselkov Kirill , Nicholson Jeremy , Darzi Ara , Takats Zoltan
Published: March 2023

Supplemental Figure 1. Association of metabolomic DESI MSI profiles of normal glandular and tumor tissue with tumor type.
Supplemental Table S4 from Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
Authors: Neskey David M. , Osman Abdullah A. , Ow Thomas J. , Katsonis Panagiotis , McDonald Thomas , Hicks Stephanie C. , Hsu Teng-Kuei , Pickering Curtis R. , Ward Alexandra , Patel Ameeta , Yordy John S. , Skinner Heath D. , Giri Uma , Sano Daisuke , Story Michael D. , Beadle Beth M. , El-Naggar Adel K. , Kies Merrill S. , William William N. , Caulin Carlos , Frederick Mitchell , Kimmel Marek , Myers Jeffrey N. , Lichtarge Olivier
Published: March 2023

Supplemental Table S4. Rate and time of tumor formation in orthotopic tongue model for individual TP53 mutations in PCI13 and UMSCC1 HNSCC cell lines.
Supplementary Methods from Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production
Authors: Chafe Shawn C. , Lou Yuanmei , Sceneay Jaclyn , Vallejo Marylou , Hamilton Melisa J. , McDonald Paul C. , Bennewith Kevin L. , Möller Andreas , Dedhar Shoukat
Published: March 2023

Supplementary Methods
Supplemental Figure S3 from Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production
Authors: Chafe Shawn C. , Lou Yuanmei , Sceneay Jaclyn , Vallejo Marylou , Hamilton Melisa J. , McDonald Paul C. , Bennewith Kevin L. , Möller Andreas , Dedhar Shoukat
Published: March 2023

G-CSF ELISA during NFκB inhibition.
Supplemental Table S2 from Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
Authors: Neskey David M. , Osman Abdullah A. , Ow Thomas J. , Katsonis Panagiotis , McDonald Thomas , Hicks Stephanie C. , Hsu Teng-Kuei , Pickering Curtis R. , Ward Alexandra , Patel Ameeta , Yordy John S. , Skinner Heath D. , Giri Uma , Sano Daisuke , Story Michael D. , Beadle Beth M. , El-Naggar Adel K. , Kies Merrill S. , William William N. , Caulin Carlos , Frederick Mitchell , Kimmel Marek , Myers Jeffrey N. , Lichtarge Olivier
Published: March 2023

Supplemental Table S2. TP53 mutations scored and stratified by EAp53 in the training dataset with associated demographic data.
Supplemental Methods from Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
Authors: Neskey David M. , Osman Abdullah A. , Ow Thomas J. , Katsonis Panagiotis , McDonald Thomas , Hicks Stephanie C. , Hsu Teng-Kuei , Pickering Curtis R. , Ward Alexandra , Patel Ameeta , Yordy John S. , Skinner Heath D. , Giri Uma , Sano Daisuke , Story Michael D. , Beadle Beth M. , El-Naggar Adel K. , Kies Merrill S. , William William N. , Caulin Carlos , Frederick Mitchell , Kimmel Marek , Myers Jeffrey N. , Lichtarge Olivier
Published: March 2023

Supplemental Methods. Description of additional methods and procedures used in the study.
Supplemental Figure Legends from Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production
Authors: Chafe Shawn C. , Lou Yuanmei , Sceneay Jaclyn , Vallejo Marylou , Hamilton Melisa J. , McDonald Paul C. , Bennewith Kevin L. , Möller Andreas , Dedhar Shoukat
Published: March 2023

Figure legends for supplemental figures 1-3
Supplementary Figures S1-S5 from Nitric Oxide Mediates Metabolic Coupling of Omentum-Derived Adipose Stroma to Ovarian and Endometrial Cancer Cells
Authors: Salimian Rizi Bahar , Caneba Christine , Nowicka Aleksandra , Nabiyar Ahmad W. , Liu Xinran , Chen Kevin , Klopp Ann , Nagrath Deepak
Published: March 2023

Supplementary Figures S1-S5. Arginase does not regulate arginine levels in OVCAs and ECAs (S1); O-ASCs induce reduced viability of cancer cells deprived of arginine (S2); L-arginase depletes arginine within the media (S3); Cancer cells induce glucose uptake and lactate secretion of O-ASCs and vice versa (S4); NO induces resistance of cancer cells to paclitaxel (S5).
Supplemental Figure S2 from Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
Authors: Neskey David M. , Osman Abdullah A. , Ow Thomas J. , Katsonis Panagiotis , McDonald Thomas , Hicks Stephanie C. , Hsu Teng-Kuei , Pickering Curtis R. , Ward Alexandra , Patel Ameeta , Yordy John S. , Skinner Heath D. , Giri Uma , Sano Daisuke , Story Michael D. , Beadle Beth M. , El-Naggar Adel K. , Kies Merrill S. , William William N. , Caulin Carlos , Frederick Mitchell , Kimmel Marek , Myers Jeffrey N. , Lichtarge Olivier
Published: March 2023

Supplemental Figure S2. Cellular proliferation is independent of TP53 status.
Supplementary Methods, Figure Legends from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
Authors: Vangamudi Bhavatarini , Paul Thomas A. , Shah Parantu K. , Kost-Alimova Maria , Nottebaum Lisa , Shi Xi , Zhan Yanai , Leo Elisabetta , Mahadeshwar Harshad S. , Protopopov Alexei , Futreal Andrew , Tieu Trang N. , Peoples Mike , Heffernan Timothy P. , Marszalek Joseph R. , Toniatti Carlo , Petrocchi Alessia , Verhelle Dominique , Owen Dafydd R. , Draetta Giulio , Jones Philip , Palmer Wylie S. , Sharma Shikhar , Andersen Jannik N.
Published: March 2023

Supplementary Methods, Figure Legends
Supplemental figure legend from mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM
Authors: Bhoopathi Praveen , Lee Nathaniel , Pradhan Anjan K. , Shen Xue-Ning , Das Swadesh K. , Sarkar Devanand , Emdad Luni , Fisher Paul B.
Published: March 2023

Supplemental figure legend for figure S1 through S8
Supplemental Figure 1 from miR30a Inhibits LOX Expression and Anaplastic Thyroid Cancer Progression
Authors: Boufraqech Myriem , Nilubol Naris , Zhang Lisa , Gara Sudheer Kumar , Sadowski Samira M. , Mehta Amit , He Mei , Davis Sean , Dreiling Jennifer , Copland John A. , Smallridge Robert C. , Quezado Martha M. , Kebebew Electron
Published: March 2023

Supplemental Figure 1: RT-PCR assay for miR-30a expression in transfected cells by either miR-30a mimic (A) or miR-30a inhibitor (B) and theirand its corresponding controls.
Supplemental Figures 1-8 from mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM
Authors: Bhoopathi Praveen , Lee Nathaniel , Pradhan Anjan K. , Shen Xue-Ning , Das Swadesh K. , Sarkar Devanand , Emdad Luni , Fisher Paul B.
Published: March 2023

Supplementary Figure 1. Expression of adenoviral receptors in neuroblastoma cells. Supplementary Figure 2. Ad.5/3-CTV induces pro-apoptotic molecules and downregulates anti-apoptotic molecules. Supplementary Figure 3. Ad.5/3-CTV induces caspase-independent cell death in neuroblastoma cells. Supplementary Figure 4. Ad.5/3-CTV enhances p53 levels in neuroblastoma cells. Supplementary Figure 5. Nuclear translocation of Î³â^'H2AX in Ad.5/3-CTV-treated neuroblastoma cells. Supplementary Figure 6. Ad.5/3-CTV infection in neuroblastoma cells promotes nuclear translocation of pATM. Supplementary Figure 7. ATM inhibitor rescues neuroblastoma cells from Ad.5/3-CTV-induced cell death. Supplementary Figure 8. Effect of Ad.5/3-CTV on MDA-7/IL-24 and AIF expression in breast cancer and melanoma cells.
Supplemental Table S2 from miR-339-3p Is a Tumor Suppressor in Melanoma
Authors: Weber Claudia E.M. , Luo Chonglin , Hotz-Wagenblatt Agnes , Gardyan Adriane , Kordaß Theresa , Holland-Letz Tim , Osen Wolfram , Eichmüller Stefan B.
Published: March 2023

Screening of 988 mimics for possible effects on the invasive capacity of A375 melanoma cells, including Table S2A: Individual testing of 988 mimics for effects on A375 melanoma cell invasion; Table S2B: Effects of 988 mimics on the invasive capacity of A375 melanoma cells in comparison to cel-miR-243; Table S2C: Effects of 988 mimics on the invasive capacity of A375 melanoma cells in comparison to ath-miR-416.
Supplementary Figures 1 - 3 from HOXB7 Promotes Malignant Progression by Activating the TGFβ Signaling Pathway
Authors: Liu Shou , Jin Kideok , Hui Yvonne , Fu Jie , Jie Chunfa , Feng Sheng , Reisman David , Wang Qian , Fan Daping , Sukumar Saraswati , Chen Hexin
Published: March 2023

Fig. S1. TGF-β/SMAD3 signaling mediates the promotion of migration and invasion by HOXB7. Fig. S2 Effects of HOXB7 overexpression and TGF-β2 knockdown on cellular morphology and proliferation rate. Fig. S3 Effects of HOXB7 overexpression on cellular morphology and proliferation rate of Her2 mouse mammary tumor cell line, H605
Supplemental Figures from miR-339-3p Is a Tumor Suppressor in Melanoma
Authors: Weber Claudia E.M. , Luo Chonglin , Hotz-Wagenblatt Agnes , Gardyan Adriane , Kordaß Theresa , Holland-Letz Tim , Osen Wolfram , Eichmüller Stefan B.
Published: March 2023

Fig. S1. Workflow for a functional screening approach to investigate miRNAs impacting on melanoma cell invasion; Fig. S2. Cell viability assay on 97 most effective miRNA candidates accelerating (A) or inhibiting (B) A375 invasion; Fig. S3. Invasive capacity of melanoma cell lines; Fig. S4. miR-339-3p inhibits invasion in various melanoma cell lines; Fig. S5. MCL1 specific siRNA inhibits melanoma cell invasion; Fig. S6. MCL1 protein expression levels determined in 14 melanoma cell lines; Fig. S7. MCL1 protein expression can be downregulated by miR-339-3p.
Supplementary Figure 2 from Identification of a Functional SNP in the 3′UTR of CXCR2 That Is Associated with Reduced Risk of Lung Cancer
Authors: Ryan Bríd M. , Robles Ana I. , McClary Andrew C. , Haznadar Majda , Bowman Elise D. , Pine Sharon R. , Brown Derek , Khan Mohammed , Shiraishi Kouya , Kohno Takashi , Okayama Hirokazu , Modali Ramakrishna , Yokota Jun , Harris Curtis C.
Published: March 2023

Representative images of CXCR2 staining in lung cancer specimens from the NCI-MD case control study.
Supplementary Methods from Histone Deacetylase Inhibitors Repress Tumoral Expression of the Proinvasive Factor RUNX2
Authors: Sancisi Valentina , Gandolfi Greta , Ambrosetti Davide Carlo , Ciarrocchi Alessia
Published: March 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplementary Figure S1 from β-Catenin Promotes Regulatory T-cell Responses in Tumors by Inducing Vitamin A Metabolism in Dendritic Cells
Authors: Hong Yuan , Manoharan Indumathi , Suryawanshi Amol , Majumdar Tanmay , Angus-Hill Melinda L. , Koni Pandelakis A. , Manicassamy Balaji , Mellor Andrew L. , Munn David H. , Manicassamy Santhakumar
Published: March 2023

Supplementary Figure S1. Pharmacological inhibition of retinoic acid synthesis limits tumor growth and T regulatory cell induction.
Supplementary Figure 1 from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

Human T cells acquire an activated phenotype after being transferred into Rag2-/-IL2Rgcnull mice.
Supplementary Figure 7 from Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
Authors: Lanzardo Stefania , Conti Laura , Rooke Ronald , Ruiu Roberto , Accart Nathalie , Bolli Elisabetta , Arigoni Maddalena , Macagno Marco , Barrera Giuseppina , Pizzimenti Stefania , Aurisicchio Luigi , Calogero Raffaele Adolfo , Cavallo Federica
Published: March 2023

Effect of immunotherapy with non CSC-specific targets
Supplementary Figure 2 from Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
Authors: Lanzardo Stefania , Conti Laura , Rooke Ronald , Ruiu Roberto , Accart Nathalie , Bolli Elisabetta , Arigoni Maddalena , Macagno Marco , Barrera Giuseppina , Pizzimenti Stefania , Aurisicchio Luigi , Calogero Raffaele Adolfo , Cavallo Federica
Published: March 2023

qPCR analysis of xCT expression in tumorspheres
Supplementary Tables 1-3 from Targeting LUNX Inhibits Non–Small Cell Lung Cancer Growth and Metastasis
Authors: Zheng Xiaohu , Cheng Min , Fu Binqing , Fan Xiaolei , Wang Qing , Yu Xiaoqing , Sun Rui , Tian Zhigang , Wei Haiming
Published: March 2023

Table S1. Clinical characteristics of the cancer patients in this study. Table S2. LunX levels in 150 cases of non-small-cell lung cancer (75 lung adenocarcinoma, 75 squamous cell lung carcinoma). Table S3. The 4-year survival rate in 102 cases of non-small-cell lung cancer (NSCLC).
Supplemental Table S1 from Perinatal and Familial Risk Factors for Brain Tumors in Childhood through Young Adulthood
Authors: Crump Casey , Sundquist Jan , Sieh Weiva , Winkleby Marilyn A. , Sundquist Kristina
Published: March 2023

Incidence rates for brain tumor subtypes by age and sex (1973-2010).
Supplementary Table S1 from IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells
Authors: Sun Zhaojun , Fourcade Julien , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Kirkwood John M. , Zarour Hassane M.
Published: March 2023

Supplementary Table S1. Description of the melanoma patients included in this study.
Supplementary Figure S3 from IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells
Authors: Sun Zhaojun , Fourcade Julien , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Kirkwood John M. , Zarour Hassane M.
Published: March 2023

Supplementary Figure S3. NY-ESO-1-specific CD8+ T cells upregulate PD-1 upon TCR activation.
Supplementary Figure S1 from Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis
Authors: Pettersson Filippa , del Rincon Sonia V. , Emond Audrey , Huor Bonnie , Ngan Elaine , Ng Jonathan , Dobocan Monica C. , Siegel Peter M. , Miller Wilson H.
Published: March 2023

Supplementary Figure S1. In vivo data from MT2186 model.
Supplementary Figure S5 from PI3K/mTOR Dual Inhibitor VS-5584 Preferentially Targets Cancer Stem Cells
Authors: Kolev Vihren N. , Wright Quentin G. , Vidal Christian M. , Ring Jennifer E. , Shapiro Irina M. , Ricono Jill , Weaver David T. , Padval Mahesh V. , Pachter Jonathan A. , Xu Qunli
Published: March 2023

Supplementary Figure S5. Representative Aldefluor FACS data of cells dissociated from MDA-MB-231 and MCF-7 tumors (Fig. 3B and 3D).
Supplemental Figure S1 from Preclinical Validation of the Utility of BLZ-100 in Providing Fluorescence Contrast for Imaging Spontaneous Solid Tumors
Authors: Fidel Janean , Kennedy Katie C. , Dernell William S. , Hansen Stacey , Wiss Valorie , Stroud Mark R. , Molho Joshua I. , Knoblaugh Sue E. , Meganck Jeffrey , Olson James M. , Rice Brad , Parrish-Novak Julia
Published: March 2023

Imaging and ROI analysis of ex vivo tumor and normal tissues.
Table 1S from Maspin Expression in Prostate Tumor Cells Averts Stemness and Stratifies Drug Sensitivity
Authors: Bernardo M. Margarida , Kaplun Alexander , Dzinic Sijana H. , Li Xiaohua , Irish Jonathan , Mujagic Adelina , Jakupovic Benjamin , Back Jessica B. , Van Buren Eric , Han Xiang , Dean Ivory , Chen Yong Q. , Heath Elisabeth , Sakr Wael , Sheng Shijie
Published: March 2023

Table 1S - Sequence of Real-Time PCR Primers
Supplementary Figure S7 from The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment
Authors: Qian Yanyan , Yuan Jupeng , Hu Huili , Yang Qifeng , Li Jisheng , Zhang Shuqian , Jiang Baichun , Shao Changshun , Gong Yaoqin
Published: March 2023

Supplementary Figure S7. CUL4B could directly bind to the promoters of the phosphatase genes and repress their transcription.
Supplementary Figure S6 from The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment
Authors: Qian Yanyan , Yuan Jupeng , Hu Huili , Yang Qifeng , Li Jisheng , Zhang Shuqian , Jiang Baichun , Shao Changshun , Gong Yaoqin
Published: March 2023

Supplementary Figure S6. p-PKCβII is downregulated in MDSCs lacking CUL4B.
Supplememtary Methods, Figures 1 - 4, Tables 1 - 3 from ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy
Authors: Morfouace Marie , Cheepala Satish , Jackson Sadhana , Fukuda Yu , Patel Yogesh T. , Fatima Soghra , Kawauchi Daisuke , Shelat Anang A. , Stewart Clinton F. , Sorrentino Brian P. , Schuetz John D. , Roussel Martine F.
Published: March 2023

Supplementary Material and Methods : Plasma pharmacokinetics of topotecan with and without the ABCG2 inhibitor Ko143. Supplementary Figure S1: RNA expression of ABC transporters in human and mouse Group3 medulloblastoma. Supplementary Figure S2: Abcg2 protein expression in mouse bone marrow from Abcg2-null mice and Group3 medulloblastoma tumor cells. Supplementary Figure S3: Dose-response of chemotherapeutic agents alone or with two Abcg2 inhibitors, Ko143 or Tariquidar. Supplementary Figure S4: Weight measurement and Abcg2 protein expression in mouse Group3 medulloblastoma during treatment. Supplementary Table 1: Affymetrix gene array analysis of genes in the porphyrin pathway in granule neuron progenitors (GNPs) and Mouse Group3 medulloblastoma tumor cells. Supplementary Table 2: Chemotherapeutic drugs tested on mouse Group3 medulloblastoma tumor cells. Supplementary Table 3: Plasma PK paramaters of topotecan after administration as single agent or in combination with the Abcg2 inhibitor Ko143.
SMovie S5 from Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
Authors: Adinolfi Elena , Capece Marina , Franceschini Alessia , Falzoni Simonetta , Giuliani Anna L. , Rotondo Alessandra , Sarti Alba C. , Bonora Massimo , Syberg Susanne , Corigliano Domenica , Pinton Paolo , Jorgensen Niklas R. , Abelli Luigi , Emionite Laura , Raffaghello Lizzia , Pistoia Vito , Di Virgilio Francesco
Published: March 2023

SMovie S5. N13R microglial cells are unable to migrate in response to wounding.
Supplementary Figure S3 from miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src
Authors: Shi Xu-Bao , Ma Ai-Hong , Xue Lingru , Li Meimei , Nguyen Hao G. , Yang Joy C. , Tepper Clifford G. , Gandour-Edwards Regina , Evans Christopher P. , Kung Hsing-Jien , deVere White Ralph W.
Published: March 2023

Immunostaining of AR-V7 in miR-124-treated 22Rv1-EnzR cells.
Supplementary Figure S1 from miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src
Authors: Shi Xu-Bao , Ma Ai-Hong , Xue Lingru , Li Meimei , Nguyen Hao G. , Yang Joy C. , Tepper Clifford G. , Gandour-Edwards Regina , Evans Christopher P. , Kung Hsing-Jien , deVere White Ralph W.
Published: March 2023

The combination treatment with miR-124 and bicalutamide (Bic) significantly inhibited proliferation of C4-2B prostate cancer cells.
Supplementary Methods and References from UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas
Authors: Wong Stephen Q. , Waldeck Kelly , Vergara Ismael A. , Schröder Jan , Madore Jason , Wilmott James S. , Colebatch Andrew J. , De Paoli-Iseppi Ricardo , Li Jason , Lupat Richard , Semple Timothy , Arnau Gisela Mir , Fellowes Andrew , Leonard J. Helen , Hruby George , Mann Graham J. , Thompson John F. , Cullinane Carleen , Johnston Meredith , Shackleton Mark , Sandhu Shahneen , Bowtell David D.L. , Johnstone Ricky W. , Fox Stephen B. , McArthur Grant A. , Papenfuss Anthony T. , Scolyer Richard A. , Gill Anthony J. , Hicks Rodney J. , Tothill Richard W.
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure S6 from Immuno-PET Imaging of Engineered Human T Cells in Tumors
Authors: Mall Sabine , Yusufi Nahid , Wagner Ricarda , Klar Richard , Bianchi Henrique , Steiger Katja , Straub Melanie , Audehm Stefan , Laitinen Iina , Aichler Michaela , Peschel Christian , Ziegler Sibylle , Mustafa Mona , Schwaiger Markus , D'Alessandria Calogero , Krackhardt Angela M.
Published: March 2023

Determination of different tumor rejection kinetics according to tumor size
Supplementary Figure S5 from Immuno-PET Imaging of Engineered Human T Cells in Tumors
Authors: Mall Sabine , Yusufi Nahid , Wagner Ricarda , Klar Richard , Bianchi Henrique , Steiger Katja , Straub Melanie , Audehm Stefan , Laitinen Iina , Aichler Michaela , Peschel Christian , Ziegler Sibylle , Mustafa Mona , Schwaiger Markus , D'Alessandria Calogero , Krackhardt Angela M.
Published: March 2023

Differential distribution of 89Zr-aTCRmu-F(ab')2 signals within ML2-B7 tumors of mice injected with 2.5D6TCR-transgenic TCM
Supplementary Figure S1 from UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas
Authors: Wong Stephen Q. , Waldeck Kelly , Vergara Ismael A. , Schröder Jan , Madore Jason , Wilmott James S. , Colebatch Andrew J. , De Paoli-Iseppi Ricardo , Li Jason , Lupat Richard , Semple Timothy , Arnau Gisela Mir , Fellowes Andrew , Leonard J. Helen , Hruby George , Mann Graham J. , Thompson John F. , Cullinane Carleen , Johnston Meredith , Shackleton Mark , Sandhu Shahneen , Bowtell David D.L. , Johnstone Ricky W. , Fox Stephen B. , McArthur Grant A. , Papenfuss Anthony T. , Scolyer Richard A. , Gill Anthony J. , Hicks Rodney J. , Tothill Richard W.
Published: March 2023

Focal copy number alterations proximal to viral integrations in V+MCC.
Supplementary Figure 2 from Evaluating Patient-Derived Colorectal Cancer Xenografts as Preclinical Models by Comparison with Patient Clinical Data
Authors: Nunes Manoel , Vrignaud Patricia , Vacher Sophie , Richon Sophie , Lièvre Astrid , Cacheux Wulfran , Weiswald Louis-Bastien , Massonnet Gerald , Chateau-Joubert Sophie , Nicolas André , Dib Colette , Zhang Weidong , Watters James , Bergstrom Donald , Roman-Roman Sergio , Bièche Ivan , Dangles-Marie Virginie
Published: March 2023

Example of 2 PDXs treated with cetuximab (one red arrow for each injection).
Supplementary Figure 1 from Evaluating Patient-Derived Colorectal Cancer Xenografts as Preclinical Models by Comparison with Patient Clinical Data
Authors: Nunes Manoel , Vrignaud Patricia , Vacher Sophie , Richon Sophie , Lièvre Astrid , Cacheux Wulfran , Weiswald Louis-Bastien , Massonnet Gerald , Chateau-Joubert Sophie , Nicolas André , Dib Colette , Zhang Weidong , Watters James , Bergstrom Donald , Roman-Roman Sergio , Bièche Ivan , Dangles-Marie Virginie
Published: March 2023

Genomic alterations of IGF2-PI3K pathway in MSS human colorectal cancer cell lines. A. Gene expression, gene copy number and mutation data provided by the Cancer Cell Line Encyclopedia were studied in the 36 MSS cell lines out of the cohort of the 62 human colorectal cell lines. Tumors were considered to be amplified if the gene copy number was >3. Gene overexpression is defined by an expression superior to average in all CRC cell line panel + 1 SD. B. Alteration frequencies are expressed as a percentage of the MSS cell lines in green. Data obtained in non-hypermutated patient tumor samples reported by the The Cancer Genome Atlas are noted in red.
Supplemental Movie S1 from Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice
Authors: Huang Jenny Li-Ying , Urtatiz Oscar , Van Raamsdonk Catherine D.
Published: March 2023

In this movie, a dark skinned Rosa26-floxed stop-GNAQ Q209L/+; Mitf-cre/+ mouse exhibits hyper-activity, head tilt, and flipping onto its back in its home cage. A lighter skinned, normally behaved Mitf-cre/+ control littermate is included for comparison.