bluuebunny/crossref_metadata_2025 huggingface dataset:
Unleashing Green Innovation in Enterprises: The Transformative Power of Digital Technology Application, Green Human Resource, and Digital Innovation Networks
Authors: Liu Jian , Wang Qibin , Wei Chaoyi
Published: December 2023

The rapid development of digital technology has injected new vitality into green technological innovation within manufacturing enterprises. Proper application of digital technology during the innovation process can propel global sustainable development. Using Chinese publicly traded manufacturing firms as a sample, this study employed a constructed digital technology innovation network and OLS models to unveil the mechanisms through which digital technology application affects green technological innovation. This research reveals a significant positive impact of the breadth and depth of digital technology applications on companies’ green technological innovation performance. Green human resource allocation serves as an intermediary in this relationship. Furthermore, the embeddedness and structural embeddedness of the digital technology innovation network play a significantly positive moderating role in the relationship between digital technology applications and green human resource allocation. This discovery provides a theoretical foundation for how companies can harness digital technology to promote green innovation within China’s digital strategy. It aids manufacturing enterprises in optimizing digital technology applications, improving green human resource allocation, and facilitating the development of digital technology innovation networks, advancing more sustainable development and contributing to global environmental goals.
Residual Lung Abnormalities in Survivors of Severe or Critical COVID-19 at One-Year Follow-Up Computed Tomography: A Narrative Review Comparing the European and East Asian Experiences
Authors: Borghesi Andrea , Ciolli Pietro , Antonelli Elisabetta , Monti Alessandro , Scrimieri Alessandra , Ravanelli Marco , Maroldi Roberto , Farina Davide
Published: December 2023

The literature reports that there was a significant difference in the medical impact of the coronavirus disease (COVID-19) pandemic between European and East Asian countries; specifically, the mortality rate of COVID-19 in Europe was significantly higher than that in East Asia. Considering such a difference, our narrative review aimed to compare the prevalence and characteristics of residual lung abnormalities at one-year follow-up computed tomography (CT) after severe or critical COVID-19 in survivors of European and East Asian countries. A literature search was performed to identify articles focusing on the prevalence and characteristics of CT lung abnormalities in survivors of severe or critical COVID-19. Database analysis identified 16 research articles, 9 from Europe and 7 from East Asia (all from China). Our analysis found a higher prevalence of CT lung abnormalities in European than in Chinese studies (82% vs. 52%). While the most prevalent lung abnormalities in Chinese studies were ground-glass opacities (35%), the most prevalent lung abnormalities in European studies were linear (59%) and reticular opacities (55%), followed by bronchiectasis (46%). Although our findings required confirmation, the higher prevalence and severity of lung abnormalities in European than in Chinese survivors of COVID-19 may reflect a greater architectural distortion due to a more severe lung damage.
Causal Relationships between Air Pollutant Exposure and Bone Mineral Density and the Risk of Bone Fractures: Evidence from a Two-Stage Mendelian Randomization Analysis
Authors: Hu Xiao , Zhao Yan , He Tian , Gao Zhao-Xing , Zhang Peng , Fang Yang , Ge Man , Xu Yi-Qing , Pan Hai-Feng , Wang Peng
Published: December 2023

A number of studies from the literature have suggested that exposure to air pollutants is associated with a declined bone mineral density (BMD), and increased risks of osteoporosis (OP) and bone fractures. This study was performed to systemically assess the genetically causal associations of air pollutants with site-/age-specific BMD and risk of bone fractures with the implementation of two-sample Mendelian randomization (TSMR) and multivariate Mendelian randomization (MVMR). The TSMR analysis was implemented to infer the causal associations between air pollutants and BMD and the risk of bone fractures, additional MVMR analysis was used to further estimate the direct causal effects between air pollutants and BMD, the occurrence of OP, and bone fractures. The results showed that NOx exposure contributed to lower femoral neck BMD (FN-BMD) (β = −0.71, 95%CI: −1.22, −0.20, p = 0.006) and total body BMD (TB-BMD) (β = −0.55, 95%CI: −0.90, −0.21, p = 0.002). Additionally, exposure to PM10 was found to be associated with a decreased TB-BMD (B β = −0.42, 95%CI: −0.66, −0.18, p = 0.001), further age-specific subgroup analysis demonstrated the causal effect of PM10 exposure on the decreased TB-BMD in a subgroup aged 45 to 60 years (β = −0.70, 95%CI: −1.12, −0.29, p = 0.001). Moreover, the findings of the MVMR analysis implied that there was a direct causal effect between PM10 exposure and the decreased TB-BMD (45 < age < 60), after adjusting for PM2.5 and PM2.5 —10 exposure. Our study provides additional evidence to support the causal associations of higher concentrations of air pollutant exposure with decreased BMD, especially in those populations aged between 45 to 60 years, suggesting that early intervention measures and public policy should be considered to improve public health awareness and promote bone health.
The Impacts of the Multispecies Approach to Caffeine on Marine Invertebrates
Authors: Baracchini Clement , Messager Lucie , Stocker Philippe , Leignel Vincent
Published: December 2023

Caffeine is one of the most consumed substances by humans through foodstuffs (coffee, tea, drugs, etc.). Its human consumption releases a high quantity of caffeine into the hydrological network. Thus, caffeine is now considered an emergent pollutant sometimes found at high concentrations in oceans and seas. Surprisingly, little research has been conducted on the molecular responses induced by caffeine in marine organisms. We studied, in laboratory conditions, six phylogenetically distant species that perform distinct ecological functions (Actinia equina and Aulactinia verrucosa (cnidarians, predator), Littorina littorea (gastropod, grazer), Magallana gigas (bivalve, filter-feeder), and Carcinus maenas and Pachygrapsus marmoratus (crabs, predator and scavenger)) subjected to caffeine exposure. The antioxidant responses (catalase, CAT; glutathione peroxidase, GPx; superoxide dismutase, SOD), lipid peroxidation (MDA), and the acetylcholinesterase (AChE) activity were estimated when the organisms were exposed to environmental caffeine concentrations (5 μg/L (low), 10 μg/L (high)) over 14 days. Differential levels of responses and caffeine effects were noted in the marine invertebrates, probably in relation to their capacity to metabolization the pollutant. Surprisingly, the filter feeder (M. gigas, oyster) did not show enzymatic responses or lipid peroxidation for the two caffeine concentrations tested. The marine gastropod (grazer) appeared to be more impacted by caffeine, with an increase in activities for all antioxidative enzymes (CAT, GPx, SOD). In parallel, the two cnidarians and two crabs were less affected by the caffeine contaminations. However, caffeine was revealed as a neurotoxic agent to all species studied, inducing high inhibition of AChE activity. This study provides new insights into the sublethal impacts of caffeine at environmentally relevant concentrations in marine invertebrates.
Serologic and Genomic Investigation of West Nile Virus in Kosovo
Authors: Emmerich Petra , Jakupi Xhevat , Sherifi Kurtesh , Dreshaj Shemsedin , Kalaveshi Ariana , Hemmer Christoph , Hajdari Donjeta Pllana , von Possel Ronald , Cadar Dániel , Tomazatos Alexandru
Published: December 2023

The prevalence of West Nile virus (WNV) is increasing across Europe, with cases emerging in previously unaffected countries. Kosovo is situated in a WNV-endemic region where the seroepidemiological data on WNV in humans remains absent. To address this issue, we have conducted a seroepidemiological investigation of 453 randomly selected sera from a hospital in Kosovo, revealing a 1.55% anti-WNV IgG seroprevalence. Comparative and phylogeographic analyses of the WNV genomes obtained by sequencing archived samples from patients with West Nile fever indicate at least two recent and distinct introductions of WNV lineage 2 into Kosovo from neighboring countries. These findings confirm the eco-epidemiological status of WNV in southeast Europe, where long- and short-range dispersion of lineage 2 strains contributes to a wider circulation via central Europe. Our results suggest an increasing risk for WNV spreading in Kosovo, underscoring the need for an integrated national surveillance program targeting vectors and avian populations for early epidemic detection, as well as the screening of blood donors to gauge the impact of virus circulation on the human population.
Immunogenic Effects and Clinical Applications of Electroporation-Based Treatments
Authors: De Robertis Mariangela , Signori Emanuela
Published: December 2023

Immunotherapy can now be regarded as an attractive approach for cancer and infectious disease treatments [...]
Generation and Characterization of ORF55/ORF57-Deleted Recombinant Cyprinid herpesvirus 2 Mutants with Chimeric Capsid Protein Gene of Grouper Nervous Necrosis Virus
Authors: Feng Zizhao , Cheng Wenjie , Ma Mingyang , Yu Chenwei , Zhang Ye , Lu Liqun , Wang Hao , Gui Lang , Xu Dan , Dong Chuanfu
Published: December 2023

Cyprinid herpesvirus 2 (CyHV-2) is a pathogen that causes significant losses to the global aquaculture industry due to mass mortality in crucian carp and goldfish. This study demonstrates that the ORF55/ORF57 deletion mutants CyHV-2-Δ55-CP and CyHV-2-Δ57-CP obtained through homologous recombination replicate effectively within the caudal fin of Carassius auratus gibelio (GiCF) cells and exhibit morphologies similar to the CyHV-2 wild-type strain. Both mutants demonstrated a decrease in virulence, with CyHV-2-Δ57-CP exhibiting a more significant reduction. This serves as a reference for the subsequent development of recombinant attenuated vaccines against CyHV-2. Additionally, both mutants expressed the inserted RGNNV-CP (capsid protein of Redspotted grouper nervous necrosis virus) fusion protein gene, and inoculation with CyHV-2-Δ57-CP-infected GiCF cell lysates elicited an antibody response in the grouper. These results indicate that, while ORF55 and ORF57 genes of CyHV-2 are not required for viral replication in vitro, they do play a role in virulence in vivo. Additionally, expression of foreign protein in CyHV-2 suggests that the fully attenuated mutant of CyHV-2 could potentially function as a viral vector for developing subunit vaccines or multivalent recombinant attenuated vaccines.
Comparative Analysis of Primary and Monovalent Booster SARS-CoV-2 Vaccination Coverage in Adults with and without HIV in Catalonia, Spain
Authors: Nomah Daniel Kwakye , Reyes-Urueña Juliana , Alonso Lucía , Díaz Yesika , Moreno-Fornés Sergio , Aceiton Jordi , Bruguera Andreu , Martín-Iguacel Raquel , Imaz Arkaitz , Gutierrez Maria del Mar , Román Ramón W. , Suanzes Paula , Ambrosioni Juan , Casabona Jordi , Miro Jose M. , Llibre Josep M. ,   the PISCIS Study Group
Published: December 2023

People with HIV (PWH) may be more susceptible to SARS-CoV-2 infection and worse clinical outcomes. We investigated the disparity in SARS-CoV-2 vaccination coverage between PWH and those without HIV (PWoH) in Catalonia, Spain, assessing primary and monovalent booster vaccination coverage from December 2021 to July 2022. The vaccines administered were BNT162, ChAdOx1-S, mRNA-127, and Ad26.COV2.S. Using a 1:10 ratio of PWH to PWoH based on sex, age, and socioeconomic deprivation, the analysis included 201,630 individuals (183,300 PWoH and 18,330 PWH). Despite a higher prevalence of comorbidities, PWH exhibited lower rates of complete primary vaccination (78.2% vs. 81.8%, p < 0.001) but surpassed PWoH in booster coverage (68.5% vs. 63.1%, p < 0.001). Notably, complete vaccination rates were lower among PWH with CD4 <200 cells/μL, detectable HIV viremia, and migrants compared to PWoH (p < 0.001, all). However, PWH with CD4 < 200 cells/μL received more boosters (p < 0.001). In multivariable logistic regression analysis of the overall population, a prior SARS-CoV-2 diagnosis, HIV status, migrants, and mild-to-severe socioeconomic deprivation were associated with lower primary vaccination coverage, reflecting barriers to healthcare and vaccine access. However, booster vaccination was higher among PWH. Targeted interventions are needed to improve vaccine coverage and address hesitancy in vulnerable populations.
Harnessing Immunity to Treat Advanced Thyroid Cancer
Authors: Komatsuda Hiroki , Kono Michihisa , Wakisaka Risa , Sato Ryosuke , Inoue Takahiro , Kumai Takumi , Takahara Miki
Published: December 2023

The incidence of thyroid cancer (TC) has increased over the past 30 years. Although differentiated thyroid cancer (DTC) has a good prognosis in most patients undergoing total thyroidectomy followed by radioiodine therapy (RAI), 5–10% of patients develop metastasis. Anaplastic thyroid cancer (ATC) has a low survival rate and few effective treatments have been available to date. Recently, tyrosine kinase inhibitors (TKIs) have been successfully applied to RAI-resistant or non-responsive TC to suppress the disease. However, TC eventually develops resistance to TKIs. Immunotherapy is a promising treatment for TC, the majority of which is considered an immune-hot malignancy. Immune suppression by TC cells and immune-suppressing cells, including tumor-associated macrophages, myeloid-derived suppressor cells, and regulatory T cells, is complex and dynamic. Negative immune checkpoints, cytokines, vascular endothelial growth factors (VEGF), and indoleamine 2,3-dioxygenase 1 (IDO1) suppress antitumor T cells. Basic and translational advances in immune checkpoint inhibitors (ICIs), molecule-targeted therapy, tumor-specific immunotherapy, and their combinations have enabled us to overcome immune suppression and activate antitumor immune cells. This review summarizes current findings regarding the immune microenvironment, immunosuppression, immunological targets, and immunotherapy for TC and highlights the potential efficacy of immunotherapy.
Performance of Human Gene EPB41L3 and HPV 16/18 Viral DNA Methylation to Triage hrHPV-Positive Women
Authors: Rezhake Remila , Wang Yan , Zhao Xuelian , Arbyn Marc , Shen Guqun , Pan Qinjing , Zhang Xun , Zhang Yuanming , Zhao Fanghui , Qiao Youlin
Published: December 2023

More evidence from population-based cohort studies is required to confirm the application of methylation-based biomarkers in real-world settings. The cross-sectional and 24-month cumulative triage performance of a novel methylation assay targeting the host gene EPB41LE and HPV16/18 DNA L1/L2 regions among hrHPV-positive women was evaluated based on a population-based cohort study from China. Overall methylation positivity was 12.4% among hrHPV-positive women. Methylation-positive women had significantly higher risks of hrHPV persistence at 12M and 24M follow-up (RR12M = 1.9, 95%CI: 1.5–2.6 and RR24M = 1.7, 95%CI: 1.2–2.5). For CIN2+, cross-sectional triage sensitivity of methylation was similar to HPV16/18 (70.6% vs. 64.7%, pexact = 1.000), but was lower than cytology (94.1%), although not significantly (pexact = 0.213). The specificity (91.2%) of methylation was significantly higher than other triage methods (p < 0.001 for all). The longitudinal sensitivity of methylation over 24M follow-up was 56.0%, lower (but not significantly so) than HPV16/18 (64.0%, pexact = 0.688) and cytology (76.0%, pexact = 0.125). Methylation testing showed high positive predictive values for CIN2+ (41.4% at baseline, 50.0% at 24-month), while the CIN2+ risk of methylation negative women (cNPV) remained considerable (2.5% at baseline, 6.9% at 24-month). Study findings indicate that methylation has better specificity and predictive values for the presence or development of cervical precancer and might therefore be considered for the strategy of HPV screening and methylation triage followed by immediate treatment of triage-positive women and delayed follow-up of hrHPV-positive/methylation-negative women.
A Survey of Fear for Others, Fear for Self, and Pandemic Anxiety Predicting Intention to Take the First Booster Vaccine to Combat COVID-19
Authors: Scudder Joseph N. , DeBeck Dennis P.
Published: December 2023

This study examined the impact of fear and anxiety on the intent to take the first COVID-19 booster vaccine. The objective of this study is to provide guidance for messaging campaigns of public health practitioners. A survey approach provided insights about individuals’ emotions of fear and anxiety related to adopting the first booster vaccine for the Coronavirus disease 2019 (COVID-19). Methods: Three independent variables were considered in their ability to predict the intent to take the first COVID-19 booster vaccine (BINT): Fear for Others (FOTH), Fear for SELF (FSELF), and COVID-19 Anxiety (CANX). Results: The confirmatory factor analysis supported an underlying three-factor solution for three central emotions in this study. A path analysis indicated significant direct effects for FOTH and FSELF in the prediction of BINT. The interdependent nature of these variables on the intent to get the first booster vaccine also was indicated by significant indirect effects. Discussion: Fear should be more precisely refined to include the fear for others (FOTH) beyond consideration of the fear for self (FSELF) from the impact of COVID-19. Conclusions: FOTH and FSELF were demonstrated to be direct predictors of BINT. CANX was only found to be significant as part of indirect effects impacting BINT. Future investigation should be given to the mediating role of anxiety with FOTH and FSELF as the context changes.
Seasonal Variations of Modern Precipitation Stable Isotopes over the North Tibetan Plateau and Their Influencing Factors
Authors: Zhu Haoran , Zhu Liping , Luo Lun , Li Jiao
Published: December 2023

Based on 360 event-based precipitation samples collected at six stations on the North Tibetan Plateau (NTP) in 2019–2020, we analyzed the influence of meteorological parameters, sub-cloud evaporation, moisture sources, and moisture transmission pathways on precipitation and its seasonal variations. The results show that precipitation δ18O, δ2H, and d-excess values show obvious seasonal variations, being depleted in winter and enriched in summer. Although temperature is an important variable that affects the change in δ18O values of precipitation, the results of the sub-cloud evaporation effect and moisture tracing show that differences in moisture sources caused by seasonal changes in large-scale water moisture transport are an important cause of seasonal changes in δ18O and d-excess of precipitation at NTP. Depleted δ18O and enriched d-excess in winter represent the source of moisture transported by the westerlies from the Mediterranean area and Central Asia. Enriched δ18O and d-excess values in summer precipitation are related to the temperature effect. In addition, the meridional motion of the atmospheric flow has an effect on the precipitation isotope values in the NTP. When the meridional circulation is enhanced, the water vapour from low latitudes is easily transported northwards, enriching the summer precipitation isotope values in the central and eastern parts of the plateau. This provides a new insight into the explanation of stable oxygen isotopes in climate proxies across the westerlies-dominated Tibetan Plateau.
Enhancing Strategic CSR in Chinese Leading Enterprises: The Role of Government Compensation and a Multi-Phase Portfolio Model
Authors: Hu Daisong , Zhao Ying , Chen Xu , Yan Yaqi , Feng Hui , Feng Jingchun
Published: December 2023

Water environment governance of large rivers is an essential measurement of ecological protection in China. The effectiveness of governance depends highly on the fulfillment of strategic CSR (corporate social responsibility) of Chinese leading enterprises. However, the fulfillment of strategic CSR often brings economic burden to the leading enterprises and needs government compensation support. Therefore, this paper explores the impact of government compensation on the fulfillment of strategic CSR of Chinese leading enterprises by constructing a multi-stage portfolio model. The main results show that (1) the prerequisite for leading enterprises to fulfill strategic CSR is sufficient profits; (2) the increase in government compensation can significantly affect the proportion of strategic CSR fulfillment of leading enterprises; (3) only when the portfolio considers both strategic CSR and project benefits, can the leading enterprises obtain the highest economic returns and better fulfill strategic CSR. The results can provide policy reference for the government to stimulate the fulfillment of leading enterprises’ strategic CSR and also give suggestions for the leading enterprises to alleviate the economic pressure brought by fulfilling strategic CSR.
Microcystis aeruginosa Removal and Simultaneous Control of Algal Organic Matter (AOM) Release Using an Electro-Flocculation–Electro-Fenton (EC-EF) System without Chemical Addition
Authors: Shen Wendi , An Lili , Xu Xin , Yan Feng , Dai Ruihua
Published: December 2023

Harmful cyanobacterial blooms pose a serious environmental threat to global water ecology and drinking water safety. Microcystis aeruginosa, a dominant cyanobacterial species in cyanobacterial blooms, was removed using the electro-flocculation–electro-Fenton (EC-EF) technology. In the EC-EF system, the iron anode was used as a sacrificial anode to produce iron ions in situ. Combining the aeration device with the graphite felt cathode as one unit realizes a direct and effective air supply to the cathode, and improves the electrical Fenton efficiency for generating oxidizing groups such as hydroxyl radicals. The cyanobacteria removal efficiency was up to 94.6% under optimal process conditions with a current density of 1.08 mA/cm2, an electrolysis time of 5 min, and an aeration flow rate of 0.06 L·min−1. At the same time, the microcystins (MCs) and total organic carbon (TOC) content in the water were controlled. The mechanism of cyanobacterial cell removal using this EC-EF system was investigated via characterization of cyanobacterial cells and flocs and cell membrane permeability analysis. The moderate oxidation and iron hydroxide encapsulation of this system are both beneficial to maintaining the integrity of cyanobacterial cells. The results demonstrated that EC-EF is a chemical-free and eco-friendly cyanobacteria removal technology.
Scanning Electron Microscope Analysis of Polypropylene Filter Cartridges Used in Drinking Water Purification Systems
Authors: Zaharia Andrei , Nedeff Valentin , López-Ramírez Juan A. , Moșneguțu Emilian , Bârsan Narcis , Lehadus-Panaite Mirela , Krzysztof Jamroziak , Tomozei Claudia
Published: December 2023

In recent years, more and more emphasis has been placed on the use of home filtration systems as a coarse pre-filtration step. The PP (polypropylene) filter cartridge is one of the most common of these systems, with the role of retaining solid suspensions from drinking water. However, few studies have focused on the fouling analysis of PP cartridges using EDS (Energy-Dispersive X-ray Spectroscopy) analysis methods. Through this study, a clear and in-depth view of the structures and morphology of PP filter cartridges as well as their impurity retention capacities and their impact is provided with the help of an SEM (Scanning Electron Microscope) analyzer. To achieve these goals, it was necessary to establish a specialized preparation methodology for this type of material in order to analyze it using the SEM and, at the same time, determine the optimal setting of the SEM parameters (improved resolution, reduced acceleration voltage, reduced data acquisition time, etc.) depending on the analysis performed for the visualization and detailed characterization of surfaces. Based on the SEM-EDS analysis and characterization, an uneven distribution of impurities on the surface of the PP fibers was identified. The number of impurities varied according to the depth of the cartridge due to the sieving effect that occurred owing to the varied sizes and shapes of the impurities, but also the structural differences and pore sizes of the filter material. So, the most common chemical elements identified were Al, Si, Na, Cl, Ca, Fe, and S, having a predominantly higher intensity from the inside to the outside of the PP filter cartridge due to pressure forces and the uneven flow of filtered water.
Study on the Spatiotemporal Variation in and Driving Mechanism of Water Quality in Baiyangdian Lake
Authors: Liu Yang , Zhang Qianqian
Published: December 2023

Analyzing 165 data from five national control sites in Baiyangdian Lake, this study unveils its spatiotemporal pattern of water quality. Utilizing machine learning and multivariate statistical techniques, this study elucidates the effects of rainfall and human activities on the lake’s water quality. The results show that the main pollutants in Baiyangdian Lake are TN, TP, and IMN. Spatially, human activities are the main drivers of water quality, with the poorest quality observed in the surrounding village area. The temporal dynamics of water quality parameters exhibit three distinct patterns: Firstly, parameters predominantly influenced by point source pollution, like TN and NH4+-N, show lower concentrations during flood periods. Secondly, parameters affected by non-point source pollution, such as TP, show higher concentrations during flood periods. Thirdly, irregular variations were observed in pH, DO, and IMN. The evaluation of Baiyangdian Lake’s water quality based on the grey relationship analysis method indicates that its water quality is good, falling within Classes I and II. Time series analysis found that the dilution effect of rainfall and the scouring action of runoff dominate the temporal variation in water quality in Baiyangdian Lake. The major pollution sources were identified as domestic sewage, followed by agricultural non-point source pollution and the release of internal pollutants. Additionally, aquaculture emerged as a significant contributor to the Lake’s pollution. This research provides a scientific basis for controlling the continuous deterioration of Baiyangdian Lake’s water quality and restoring its ecological function.
Bullying dan Penanganannya
Authors: Noviyanti Nurwalidah
Published: December 2023

Penelitian ini bertujuan mengetahui: (1) Gambaran perilaku bullying pada siswa, (2) Faktor penyebab perilaku bullying pada siswa, (3) Dampak perilaku bullying pada siswa, (4) Penanganan perilaku bullying di MTs. Sultan Hasanuddin Kab. Gowa. Jenis penelitian ini adalah penelitian studi kasus dengan pendekatan kualitatif. Instrumen penelitian ini adalah observasi, wawancara, dan dokumentasi. Hasil penelitian ini menunjukkan bahwa: (1) Gambaran perilaku bullying berupa bullying verbal seperti mengejek, memanggil dengan nama julukan dan memanggil dengan nama orangtua, (2) Faktor penyebab perilaku bullying adalah lingkungan sekolah, lingkungan sosial dan faktor pribadi, (3) Dampak perilaku bullying bagi pelaku pada hubungan sosialnya, siswa yang lain ikut-ikutan berperilaku bullying, (4) Upaya penanganan yang dilakukan peneliti dengan pemberian konseling menggunaan teknik Selftalk dilaukan untuk memberikan sugesti atau dorongan motivasi kepada diri sendiri untuk bertindak seperti apa yang diharapkan agar tidak melaukan perilaku bullying. Hal tersebut menunjukkan bahwa penanganan yang dilakukan dengan teknik Selftalk memberikan dampak positif terhadap penurunan intensitas perilaku bullying yang dilakukan.
The Role of Village-Owned Enterprises (Bumdes) in Managing Prime Educational Tourism Selemak, Hamparan Perak North Sumatera
Authors: Sinaga Caroline , Simanjuntak Anggraini Oktaviani Pauline , Ginting Arca Iswari Br , Napitupulu Inda Triwana
Published: December 2023

Prima Wisata Edukasi Selemak is an educational destination that is very suitable to be used as a place to relax. Prima Wisata Edukasi Selemak is located on Ustad. H. Abdul Khadir Nuh, Kelumpang, Kec. Hamparan Perak, Kab. Deli Serdang, North Sumatra 20256. This study aims to determine the role of BUMDes in the governance of Prima Selemak Educational Tourism and to analyze the role of BUMDes in managing Selemak Educational Tourism, Hamparan Perak. To find out the government's contribution to BUMDes in increasing the management revenue of Prima Wisata Edukasi Selemak. This research uses qualitative methods obtained through visits to Prima Wisata Edukasi Selemak. It uses data collection methods through in-depth interview observations with BUMDes administrators or managers based on informants who are one of the BUMDes sections and are also of the village officials of Prima Wisata Edukasi Selemak. In general, this research can provide information related to BUMDes in the management of Selemak Village. Prima Wisata Edukasi Selemak is assisted by BUMDes in managing this tourism business so that the results are by the previously compiled process. BUMDes focuses on addressing this Village by providing services in the field of promotion in the introduction of these tourism businesses. The results of the discussion of this research are some of the roles of BUMDes in the governance and development of the Selemak Prima Edukasi Tourism Park, namely, as a driver and as a reference in bringing high multiplier effects to local communities, and also plays a role in the development, empowerment and development of the community in the Village. The government has yet to contribute to increasing revenue at Taman Wisata Edukasi Selemak. Still, in providing education to local communities, the government has taken part and promoted Taman Wisata Edukasi Selemak.
Cases on Arts Entrepreneurship
Authors: Wyszomirski Margaret J.
Published: December 2023

Cases on Arts Entrepreneurship (Tonelli, M., & Heise, A. [Eds.]. [2023]. Cases on Arts Entrepreneurship. Edward Elgar Publishing) presents a collection of thirteen case studies that will be much appreciated by professors who teach and students who are studying entrepreneurship in the arts. Each case study exhibits a similar framework: a descriptive narrative that runs between seven and sixteen pages, including references; Teaching Notes that include an abstract, learning outcomes, keyword topics, discussion questions, a seventy-five-minute class plan, and supplemental readings (if any). The editors provide a brief introduction to the book’s purpose as well as a seven-page concluding chapter that identifies five themes that emerge across chapters: exposure to the arts at a young age, network and relationship building, kindness and collaboration, financial management, and balancing multiple income streams.
Embracing Tradition: Classical Studio in 2022
Authors: Moore Cameron
Published: December 2023

The year 2022 saw the return of Classical Studio within the Unitec | Te Pūkenga School of Architecture after a ten-year hiatus. In Classical Studio, the goal isn’t necessarily to teach how to design a classical building, but to give third- and fourth-year students a deeper understanding of proportional and compositional principles, and a way to generate and evaluate with traditional design methodology. This time the studio was offered to second-year students, presenting new pedagogical opportunities. The criteria for the second-year studio are outlined, as well as how a classical approach to architectural design is aligned with these criteria. The brief was found in a 101-year-old issue of N.Z. Building Progress, in an architectural competition conceived and judged by Reginald Ford, the founding member of Gummer and Ford, perhaps New Zealand’s most influential architectural practice. In a departure from the traditional Unitec Classical Studio, the students were required to present their final designs with CAD instead of watercolour, the opportunities and challenges of which are discussed. This article explains the design process behind the studio, how the brief was interrogated and developed, and what steps the students took to learn how to design a classical building. But more importantly, what lessons were learned from following this process, and how a sampling of classical instruction can fit into a modern architectural education.
Is Our Heritage Falling Through the Gaps?
Authors: Vadasz Viola , Jadresin Milic Renata , Raza Khan Iman
Published: December 2023

When it comes to an urban environment, the first things that often come to mind are the buildings, structures and spaces that surround us and have meaning for us. In Aotearoa New Zealand, we also have explicitly significant buildings and structures that we consider part of our heritage, despite being relatively young compared to many other nations. The country’s cultural heritage sites, buildings and objects are treasures of distinctive value. They can be roughly divided into four overlapping categories: archaeological sites, historic buildings and structures, places of significance to Māori, and cultural landscapes.2 All ethnic groups residing in Aotearoa New Zealand have contributed to the country’s cultural heritage, and “the result is an evolving mix of Polynesian, European, and also Asian, ways of seeing and doing, making each new generation of New Zealanders slightly different from the previous one and yet intimately linked to it.”3 These heritage sites and buildings are part of our urban and rural environment, and are assets with distinctive value and meaning to both Māori and Pākehā.
Perancangan Kembali Antarmuka Web BPS dengan Pendekatan User Centered Design
Authors: Samu Chairunnisa Fauzia , Maghfiroh Lutfi Rahmatuti
Published: December 2023

Pada tahun 2021, BPS menyelenggarakan Survei Kepuasan Pengguna Website (SKPW). Hasil SKPW menunjukkan bahwa aspek pelayanan website BPS secara keseluruhan berada dalam kategori baik, namun masih ada beberapa aspek yang memiliki nilai kepuasan pengguna yang masih kurang dibandingkan dengan harapan pengguna seperti kelengkapan metadata, kesesuaian produk dengan kebutuhan, kemudahan navigasi, kemudahan mencari produk, kehandalan fungsi pencarian, ketertarikan tampilan website, ketepatan penyusunan tata letak, ketersediaan dua bahasa, dan kemudahan mendapatkan panduan penggunaan website. Oleh karena itu, perlu adanya perancangan user interface website BPS yang baru yang dapat memuaskan pengguna website sesuai dengan harapan pengguna.  Metode yang digunakan dalam penelitian ini adalah User Centered Design (UCD) dengan menggunakan User Experience Questionnaire (UEQ) sebagai metode evaluasi. Selain itu, dilakukan juga evaluasi kepuasan pengguna terhadap rancangan antarmuka yang baru untuk dibandingkan dengan SKPW 2021. Agar ukuran kepuasan pengguna yang dihasilkan dapat dibandingkan dengan hasil evaluasi SKPW 2021, digunakan metode analisis kepuasan yang sama dengan yang digunakan di SKPW 2021 yaitu Importance Performance Analysis (IPA). User interface baru yang telah dirancang telah dievaluasi ke pengguna sebanyak dua kali iterasi dengan hasil evaluasi terakhir yaitu tingkat kepuasan seluruh aspek pelayanan yang menjadi cakupan penelitian ini telah mengalami peningkatan dibandingkan dengan hasil SKPW 2021.
Metode Hutan Ordinal untuk Klasifikasi Desa Sesuai dengan Status Indeks Desa Membangun
Authors: Sirodj Dwi Agustin Nuriani , Khairil Anwar Notodiputro  , Bagus Sartono
Published: December 2023

Metode hutan acak merupakan metode klasifikasi berbasis pohon yang cukup populer. Metode ini jika diterapkan pada peubah respon ordinal akan memberikan hasil yang mengubah karakteristik dari data ordinal itu sendiri. Dalam tulisan ini akan dibahas kinerja dari metode hutan ordinal dan hutan ordinal Naïve untuk klasifikasi status berbagai desa sesuai dengan Indeks Desa Membangun (IDM) di kabupatenTasikmalaya dan Indramayu. Hasilnya memperlihatkan bahwa untuk Kabupaten Tasikmalaya kinerja metode hutan ordinal mengungguli kinerja hutan ordinal Naïve dengan rataan akurasi sebesar 73.8% dan rataan nilai kappa sebesar 0.18 sedangkan pada Kabupaten Indramayu kinerja metode hutan ordinal naïve yang justeru mengungguli metode hutan ordinal dengan rataan akurasi sebesar 51.6 % dan rataan nilai kappa sebesar 0.162. Selain itu ditunjukkan pula bahwa peubah yang penting dalam proses klasifikasi status IDM di Kabupaten Tasikmalaya dan Kabupaten Indramayu adalah peubah Jumlah Koperasi dan Jarak terdekat ke rumah sakit.
The roles of polyamines in Malaysian herbs as a chemoprevention strategy: A scoping review
Authors: Azalan Maryam Syahidah , Abdul Ghani Radiah , Wallace Heather M.
Published: December 2023

Maintaining normal polyamine levels is crucial for the physiological cellular process and differentiation because an imbalance of polyamine concentration affects the occurrence of neoplastic activities in many types of cancer diseases. Malaysian herbs have been purported to have anticancer properties that influence the polyamine’s bioavailability, leading to cancer cell death. Presently, the roles of polyamines in Malaysian herbs as chemoprevention have yet to be documented. Thus, this review aims to determine which Malaysian herbs have chemoprevention properties affecting polyamines and appraise the relationship between polyamine levels and Malaysian herbs and their cytotoxicity on cancer cells. The search, employing keywords like “Malaysian herbs”, “polyamines”, and “anticancer” or “chemoprevention”, yielded 256 articles. The articles were screened for their eligibility, befitting the objectives mentioned. The PRISMA-ScR checklist was employed to report the published findings from the databases. Thirteen articles meeting inclusion criteria were selected, highlighting 13 Malaysian herbs influencing the intracellular polyamines pathway. All herbs showed a significant reduction in ornithine decarboxylase (ODC) expression. In addition, Alpinia galanga and Aloe barbadensis showed an increase in catabolic polyamines expression, spermidine/spermine-N-acetyl transferase (SSAT) and spermine oxidase (SMO), respectively, leading to growth arrest and induction of apoptosis in cancer cells. The in vitro and in vivo studies demonstrated these herbs’ anti-proliferative effects on diverse cancer types, involving polyamine level modulation, intracellular dynamics, and chemopreventive mechanisms through apoptosis and anti-inflammatory responses. The findings underscore the potential of Malaysian herbs in cancer prevention by modulating the polyamine pathway.
Association of microRNA-155 gene polymorphism and the incidence of systemic lupus erythematosus in Iraqi patients
Authors: Khudhair Iman Abbas , Mohsen Rana Talib , Alalwani Anmar Kamil
Published: December 2023

An intricate, multisystemic autoimmune disease that affects multiple organs is known as systemic lupus erythematosus, or SLE. Alterations in genetic material contribute to the development of SLE. The present work aims to investigate the association of genetic variants of microRNA-155 (miR-155) that are essential in the pathogenesis of SLE. A case-control study was conducted with40 female patients and 40 healthy individuals as control group who were from the Medical City/Baghdad Teaching Hospital. The molecular study of miR-155 was performed by polymerase chain reaction using uniquely designed primers followed by sanger sequencing the results showed that wild type was present in all 80 samples. This study also detected two SNPs (rs190708267 and rs1547354) under the control group. According to NCBI, the SNPs detected are not related to any disease, but may be protective factors in healthy individuals.
Complications from the use of cyanoacrylate glue in conjunctival grafting for pterygium surgery: a case report
Authors: Lim Yi Xuan , Teow Kenneth Kheng Leong
Published: December 2023

Background: Pterygium is a wing-shaped fibrovascular tissue overgrowth of the conjunctiva that crosses over the nasal or temporal limbus, or both, and grows onto the corneal surface. We report a case of complications due to the use of cyanoacrylate glue in conjunctival grafting in pterygium surgery. Case presentation: A 70-year-old Iban woman presented with worsening foreign body sensation in the nasal aspect of the left eye 10 years after undergoing nasal pterygium excision. The foreign body sensation had worsened over the course of 1 year. Upon examination, a greyish foreign body in the nasal aspect of the left eye(acrylate-like material) was noted. Conclusion: In this case report, we highlight the complications of the usage of cyanoacrylate glue in pterygium surgery and the possible intraoperative complications in this case.
Identification of the risk of anterior cruciate ligament injury by muscle strength balance assessment
Authors: Yuliana Ela , Diyananda Dzulfiqar , . Yuliasih
Published: December 2023

This study aims to identify the risk of anterior cruciate ligament (ACL) injury in petanque athletes at Jakarta State University (UNJ). This research is a quantitative descriptive study using a cross-sectional survey design. There were 18 research subjects consisting of 10 male athletes and 8 female athletes. Characteristics of research subjects such as body weight and Body Mass Index (BMI) were measured using the Xiaomi MI scale. Assessment of hamstring and quadriceps muscle strength is assessed using an electromyography (EMG) tool when performing manual muscle testing (MMT). The research results showed that the research subjects had a normal BMI category, namely 22.31 for men and 22.09 for women. Statistically, there were no significant differences in hamstring and quadriceps muscle strength in the right (p=0.448) and left (p=0.376) legs for male subjects. Meanwhile, for female subjects, there was also no significant difference found between hamstring and quadriceps muscle strength on the right (p=0.429) and left (p=0.232) legs. Thus, it can be concluded that UNJ petanque athletes have a low risk of ACL injury, because they have hamstring and quadriceps muscle strength that is not significantly different (balanced), and is supported by a normal BMI category. Further studies need to be carried out by combining and considering other variables in identifying the risk of ACL injury.Key word:  anterior cruciate ligament injury, electromyography, muscle strength balance
Video-based learning media for physical education
Authors: Triansyah Andika , Atmaja Nur Moh Kusuma , Sepdanius Endang
Published: December 2023

The use of video is only one tool that can enhance students' learning experience in the field of physical education. From the explanation above, it can be concluded that the integration of learning media in the learning process itself cannot be released, so efforts are needed to produce varied learning media and can be used to support the learning process. The integration of learning media in the physical education learning process cannot be ignored, so efforts are needed to produce varied learning media and can be used to support the learning process. This study aims to produce physical education learning videos using the ADDIE model starting from analyze, design, development, implementation, and evaluation. The data were analyzed by qualitative descriptive and quantitative descriptive techniques. The results showed that the assessment by material experts received a 90% rating (very good), then media experts got 83% (good) and user responses got 85% (good). Furthermore, the calculation of the influence of video on learning outcomes has an effect size of 1.09 which is included in the high-influence category.. The use of video as support should still pay attention to direct interaction between teachers and students, as well as opportunities to practice and participate actively. The integration of learning media in the learning process cannot be ignored, with the integration proven to have a positive impact on learning outcomes.Key words: Video-based learning, physical education, learning media.
Development of the case method in anti-corruption education courses in physical education and sports
Authors: Aprial. M Benny , Rahmat Zikrur , Alfiansyah Putra Karo-karo Alan , Giawa Epenetus
Published: December 2023

The purpose of this study is to create a course design for Anti-Corruption Education at Sekolah Tinggi Olahraga dan Kesehatan Bina Guna that incorporates the case method idea into the Physical Education Study Program. According to Borg and Gall's research and development research, it took more than three months to complete, with the following details: Needs analysis, Planning for model creation, Creation of exercise model designs, Model modification and expert validation, Trials and adjustments in small groups, Field tests and modificationsThe research's findings demonstrate that: the case method's development for anti-corruption education courses is appropriate for use as a learning tool, as evidenced by the expert validation results in the case method aspect, which obtained percentages of 81.25%, 94.61%, and excellence of 79.17%; the material expert validation results in the learning design aspect, which obtained percentages of 80%, 81.25%, and 85% in the excellence aspect; and the student assessments results in the case method aspect, which obtained a percentage of 78, 94%. The research conclusion is one way to train students' talents in rhetorical, realistic and critical thinking, as well as basic research is through case method-based learning which originates from field observations and investigations and the findings of this research are consistent with other research regarding the case approach of anti-corruption teaching programs in education physical.Key words: development, case method, anti-corruption education.
Assistance using mobile learning applications to improve skills physical education teacher in the 4.0 era
Authors: Aryanti Silvi , Hartati Hartati , Destriana Destriana , Victorian Ahmad Richard , Setiyo Edi , Nanda Fitri Agung , Destriani Destriani , Azhar Samsul , Motik Dewi
Published: December 2023

The aim of this research is to evaluate the effectiveness of support in the utilization of mobile learning applications among 38 Physical Education, Sports, and Health Teachers in Lahat Regency. Employing a quantitative descriptive methodology through a survey approach, the research encompasses pre-test and post-test assessments. During the pre-test phase, the results highlight a deficiency in teachers' knowledge regarding mobile learning applications, specifically in comprehending their purpose and operational functionalities. Nonetheless, the post-test outcomes signify a significant enhancement, revealing that the teachers developed awareness and proficiency in utilizing mobile learning applications. They demonstrated an improved understanding of the applications' objectives and acquired the necessary skills for their effective implementation. The transition from the pre-test to the post-test phase signifies the success of the provided assistance in bridging the knowledge gap among the teachers. This implies that the intervention, likely delivered in the form of training or guidance, positively influenced the participants' comprehension and utilization of mobile learning applications. The research findings underscore the critical role of targeted support in augmenting educators' familiarity with technology, ultimately contributing to the seamless integration of mobile learning tools in educational settings. Consequently, this study makes a noteworthy contribution to the ongoing discourse on the significance of mobile applications in pedagogy, particularly within the domain of Physical Education, Sports, and Health.Key words: mobile learning, physical education, era 4.0.