bluuebunny/crossref_metadata_2025 huggingface dataset:
Microbiological screening of compounds with potential anti-lep activity among new synthesis compounds of the pyrimidine series
Authors: Lutsenko A. V. , Yushin М. Yu. , Genatullina G. N. , Tyrkov A. G. , Ayupova A. K. , Saroyants L. V. , Starikova A. A. , Samotrueva M. A.
Published: April 2023

Aim. To study the effect of new synthesized pyrimidine derivatives on the growth of Mycobacterium lufu (M. lufu) and Mycobacterium tuberculosis (M. tuberculosis) when cultivated on Shkolnikova's medium.

Materials and methods. The objects of research were new synthesized derivatives of 6 samples of derivatives of pyrimidine - 5-(arylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-trions under laboratory codes TAG1, TAG2, TAG3, TAG4, TAG5, TAG6 and 7 samples of 5-(getarylmethylidene)-2,4,6-pyrimidine-2,4,6(1H, 3H, 5H)-trions under the laboratory codes TAG7, TAG8, TAG9, TAG10, TAG11, TAG12, TAG13. M. lufu and M. tuberculosisH37Rv strains were used as test cultures. The antimycobacterial activity of the studied compounds was studied by the method of serial dilutions.

Research results. All studied compounds were found to exhibit antimycobacterial activity. The greatest inhibitory effect against M. lufu was noted for TAG1, TAG4, TAG7, TAG12, and TAG13, which was comparable to that of the reference drug dapsone. By the nature of the inhibitory effect on the growth of M. tuberculosis, the compounds under the laboratory codes TAG 1, TAG 4, TAG 7 and TAG13 were comparable to isoniazid, and the effect of the TAG3 compound was even slightly superior to the reference drug.

Conclusion. Among the studied new synthesized pyrimidine derivatives, compounds under the laboratory codes TAG1, TAG4, TAG 7 and TAG13 have the most pronounced antimicrobial activity both against M. lufu and M. tuberculosis, which allows us to consider them as the most promising substances for further research on the search for antimycobacterial, including antileprosy drugs.
Myocardial inotropic response of rats of different ages to extrasystolic exposures in postinfarction cardiosclerosis
Authors: Rebrova T. Yu. , Kondratieva D. S. , Afanasiev S. A. , Ostrovik M. O. , Popov S. V.
Published: April 2023

The age-dependent features of the inotropic response of isolated strips of rat papillary muscles in postinfarction cardiosclerosis were studied. The rhythmic-inotropic response of the myocardium to extrasystolic effects was assessed in sham-operated (SO) rats and rats with established post-infarction cardiosclerosis (PICS) in the age groups of 4, 12, and 24 months (mon). It was shown that the excitability of the sarcoplasmic membrane of cardiomyocytes increases in 12-mon-old SO animals, and decreases in 24-mon-old animals relative to the group of 4-mon-old SO animals. The ability of the sarcoplasmic reticulum (SPR) of cardiomyocytes to accumulate calcium ions (Ca2+) does not depend on age. Postinfarction myocardial remodeling is accompanied by a decrease in the excitability of the sarcolemma in 4-mon-old animals and an increase in 24-mon-old animals relative to the values in SO rats of the corresponding age. At the same time, the Ca2+-accumulating ability of the SBP decreases in 4- and 12-mon-old animals, remaining unchanged in 24-mon-old animals.
Study of radiation-induced pneumonitis after arc and static irradiation in lungs of rats
Authors: Pashkovskaya O. A. , Filatova N. A. , Dokuchaeva A. A. , Shigaev V. V. , Krasilnikov S. E.
Published: April 2023

The clinical application of the results of the experimental radiotherapy on animals is currently not widely used. The research of radiation injuries after irradiation target in rat lungs using the image-guided platform SmART+ (Precision, North Branford, Conn., USA) is a pilot study for the establishment of an animal model of radiation-induced pulmonary toxicity.

Aim: To define the typical doses and target volumes in rat lung to o serve radiation pneumonitis.

Material and methods. Four groups of Wistar and Wag rats, distinguishing by age (10–16,5 months) and weight (350-850 g.), were studied. Dosimetric treatment plans were calculated prior to irradiation, using arc or static methods, doses (10–30 Gy), target lung volumes (0,045–1,24 cm3), localization (right or left, top or bottom). Dosimetric planning provides optimal radiation exposure to the target and controls organ at risk doses. Computer tomography (CT) scans were performed for 16 weeks to observe radiation pneumonitis

Results. To obtain the rat lung density in Hounsfield units (HU), healthy animals were scanned, CT images were processed, and the mean and standard deviation were calculated. Lung density values of rats (control values) are 519.6 ± 46.2 (HU). Comparison of experimental data on irradiated animals and control values was carried out. As a result, the relationship of the target volume, the delivered dose and the survival rate of animals after irradiation was established. It was shown that the “mean value of lung density” could be used for quantitative analysis of lung injuries after irradiation.

Conclusion. Typical doses and target volumes in rat lungs to observe radiation pneumonitis were obtained. Decreasing aeration of lung tissue was derived at delivered dose 16 Gy and irradiated target volume in lung at least 0.5 cm3 (8%).
Effects of a high-carbohydrate high-fat diet on liver morphology in young and old rats
Authors: Mustaﬁna L. R. , Logvinov S. V. , Bogdanova L. I. , Kurbatov B. K.
Published: April 2023

The liver is a complex metabolic organ that, through the regulation of energy metabolism, maintains the homeostasis of the whole organism.

Aim: To establish the morphological changes in hepatocytes and the expression of endothelial vascular factor in a high-carbohydrate high-fat diet (HCHFD) depending on age.

Material and Methods. A histological study of the liver was carried out in four groups of male Wistar rats: 1st group – 5-month-old animals on a standard diet; 2nd  group – 5-month-old animals on HCHFD for 90 days (from 2 months of age); 3rd  group – 18-month-old animals on a standard diet; 4th  group – 18-month-old animals on HCHFD for 90 days (from 15 months of age). Using morphometric methods, the specific volumes (%) of unchanged and binuclear hepatocytes, sinusoidal capillaries, inflammatory infiltrates, and foci of fibrosis in the liver were determined. The expression of vascular endothelial growth factor (VEGF) in endothelial cells and hepatocytes was evaluated by immunohistochemical method. The concentration of cholesterol and triglycerides was determined by the enzymatic colorimetric method in the blood serum and in the liver.

Results. A morphological study revealed a significant expansion of sinusoidal capillaries in groups 2 and 4. A statistically significant increase in the specific volume of hepatocytes with vacuolar inclusions, binuclear hepatocytes, fibrous foci and small inflammatory infiltrates was detected in the 4th  group. VEGF expression increased in hepatocytes of groups 2 and 4. Biochemical study found an increase in the concentration of triglycerides in the rats’ liver of the 4th  group. Thus, HCHFD, despite the pronounced signs of regeneration, increased age-related changes in the liver of old rats.
Inducible NO synthase as a pharmacological target of anti-inflammatory therapy: hope is not lost?
Authors: Galagudza M. M. , Belsky Yu. P. , Belsky N. N.
Published: April 2023

The review is devoted to the current assesment of the role of nitric oxide and inducible NO-synthase in physiological and pathological conditions. The inducible NO-synthase gene expression induction and post-transcriptional regulation of its activity are considered. Data on endogenous inducible NO-synthase inhibitors of are given. An analysis of the clinical trials aimed at studying the clinical efficacy of NO synthase inhibitors was carried out.
The role of immune-inflammatory mechanisms in the pathogenesis of hypertension
Authors: Mordovin V. F. , Zyubanova I. V. , Manukyan M. A. , Dorzhieva I. K. , Vtorushina A. A. , Khunkhinova S A. , Falkovskaya A. Yu.
Published: April 2023

Hypertension remains the main risk factor of cardiovascular diseases despite the improvement of pharmacotherapy methods. This provides rationale for an in-depth study of pathogenetic mechanisms and development of new methods for the treatment of hypertension. There is increasingly more evidence for the essential role of immune-inflammatory disorders in the pathogenesis of hypertension. The article reviews the current state of knowledge on this problem. The authors provide a detailed analysis of the studies focusing on the role of abnormal factors of cellular immunity essentially associated with cell abilities to produce pro-inflammatory cytokines. Particular attention is paid to the effects of state-of-the-art methods of endovascular treatment on the changes in degree of severity of immune-inflammatory processes in patients with pharmacotherapy resistant form of hypertension. Possible mechanisms of the therapeutic action of renal denervation and the prospects for further clinical use of this method are discussed.
Ceramides: correlation with cardiovascular risk factors
Authors: Belik E. V. , Dyleva Yu. A. , Gruzdeva O. V.
Published: April 2023

Despite the successes achieved, cardiovascular disease (CVD) remains the leading cause of death worldwide. With the help of traditional risk factors, it is not always possible to identify all patients with a high probability of developing cardiovascular events (CVЕ); therefore, the problem of finding new CVD biomarkers still remains relevant. Previous studies have shown the important role of excessive synthesis of ceramides in the development of obesity, insulin resistance (IR), type 2 diabetes mellitus (DM2), and liver steatosis. It is considered that ceramides are able to modulate signaling pathways involved in the regulation of glucose metabolism, triglyceride synthesis, development of apoptosis, fibrosis, and atherosclerosis. Given the wide range of metabolic effects, the study of ceramides is promising for identifying patients at high risk of CVD, as well as improving existing treatment and diagnostic strategies. This review article considers the role of ceramides in the development of atherosclerosis, the correlation with traditional risk factors, and the possibility of using them as new risk factors for early diagnosis of CVD.
Recent assessment methods of epicardial adipose tissue
Authors: Vasilkova T. N. , Mischenko T. A.
Published: April 2023

Epicardial adipose tissue (EAT) is a visceral depot of the heart fat, which has high plasticity and directly contact with the myocardium and coronary arteries. Epicardial fat is a unique paracrine organ closely anatomically and physiologically related to the myocardium. Recent studies have repeatedly confirmed the role of epicardial fat in the progression of the cardiovascular diseases. The accumulation of EAT, measured by using new non-invasive imaging techniques, is prospectively associated with the onset and progression of coronary heart disease (CHD) and atrial fibrillation. This review focuses on modernin vivomethods for assessing epicardial fat.
The role of the hydrogen sulfide donor in adenosine diphosphate-induced platelet aggregation in patients with coronary heart disease
Authors: Petrova I. V. , Trubacheva O. A. , Birulina Ju. G. , Chumakova S. P. , Gusakova S. V.
Published: April 2023

Introduction. Platelet activation is the initial stage of thrombotic complications in pathological conditions, primarily in atherosclerotic cardiovascular diseases. Endogenous hydrogen sulfide (H2S) is an antiplatelet agent, but the specific ways to realize its effects are not studied enough

Aim: To study the effect of H2S on adenosine diphosphate (ADP)-induced platelet aggregation in patients with coronary heart disease (CHD) with blockers of Na+,K+,2Cl-cotransporter (NKCC), an anion exchanger, and a phosphodiesterase (PDE) inhibitor of cyclic nucleotides.

Material and Methods. The study included 22 patients with CHD. The control group included 14 healthy volunteers. Platelet aggregation was determined by turbidimetric method. The degree of aggregation (%) and the size of aggregates (rel. units) were measured. ADP (2 μM) was an aggregation inductor. In some cases the incubation medium contained the hydrogen sulfide donor NaHS (1–100 μM) and aggregation modifier

Results. The H2S donor at a concentration of 100 μM reduced the parameters of ADP-dependent platelet aggregation in healthy volunteers and increased it in patients with coronary artery disease. NKCC and anion exchanger blockers, as well as a PDE inhibitor, reduced ADP-dependent platelet aggregation in healthy volunteers. The combined action of these agents and NaHS enhanced the inhibitory effects of the applied modifiers. The results obtained for platelet aggregation in patients with coronary artery disease differed in different direction

Conclusion. The obtained data indicate that the antiaggregation effect of H2S is realized through the effect on the NKCC and anion exchanger, as well as due to the effect on the links of the signaling system mediated by cyclic nucleotides.
Influence of a high-carbohydrate high-fat diet on age-related changes in the myocardium in rats
Authors: Logvinov S. V. , Mustafina L. R. , Kurbatov B. K. , Sirotina M. A. , Gorbunov A. S. , Naryzhnaya N. V.
Published: April 2023

The increase in cardiovascular diseases and metabolic disorders associated with longevity actualizes the study of the effect of high-calorie diets on heart aging.

Aim: the experimental study of the effect of a high-carbohydrate hig -fat diet on the myocardium in young and old age.

Material and Methods. A morphological study of the myocardium was carried out in four groups of male Wistar rats: group 1 - 150-day-old animals were kept on a standard diet; 2nd - 150 days, kept at a high-carbohydrate high-fat diet (HCHFD) for 90 days (from 60 days of age); 3rd - 540 days old, kept on a standard diet; 4th - 540 days old, kept at HCHFD for 90 days (from

450 days of age). ELISA method in blood serum was used to determine the concentration of fibronectin, transforming growth factor beta-1, connective tissue growth factor.

Results. In groups 2-4, leukostasis, focal lympho-monocytic infiltration of the myocardial stroma, an increase in the number of myocardial cells with karyopyknosis and edema of the perinuclear zone of the sarcoplasm, contracture disorders, and an increase in the specific volume of the connective tissue of the stroma were detected. The defeat of myocardial cells and fibrosis were most pronounced in group 4. HCHFD increased the concentration of fibronectin in animals in both age groups with predominance in group 4, caused a tendency to increase the content of transforming growth factor beta-1, connective tissue growth factor in blood serum. Thus, HCHFD accelerates and enhances age-related changes in the white rat myocardium.
السميائيات التأويلية: بحث في مستويات الإدراك والتأويل
Authors: علوي عبد السلام إسماعيلي , دودي عبد الرحيم
Published: April 2023

لقد استطاعَ الإنسانُ بالعلامات ومن خلالهَا أن يعبُر من العالم الطبيعي المادي إلى العالم الثقافي الرمزي، لقد استطاع أن يُنتِج فكره الخاص، وأن يبني ذاكرته الجماعية الوضعية، تارك وراءهُ كلَّ الكائنات بلا فكرٍ ولا مرجع ولا ذاكرة، تعيش وفق مسارٍ طبيعي لا يتغير، أي وفق مسار نمطي يتكرر؛ ولكنه لا يتطور. إِنَّ العلامةَ هيَّ الوسيلة التي من خلالها تأنسن الإنسان، وخلَّص نفسه من إكراهات الطبيعة، إلى رحابة الثقافةِ التي منحتهُ أدواتٍ رمزية أودعَ فيها قيَمهُ وآمالَهُ وأحلامَه، وضمّنها عاداته وتقاليده. لقد مكنت العلامات الإنسانَ من إعادةِ صياغةِ الوجودِ خارج إكراهات التجسيد والحضورِ الماديّ للأشياء، لقد يسرتْ له مَفْهَمَة الكون وسَمْيَأَتَهُ، يسرت له تقطيعه وتصنيفه داخل عوالم تجريدية رمزية مخصوصة. وبذلك تمكَّن من امتلاك هذا الكون ذهنيًا والإمساك بدلالاته معرفيًا، حتى غدا متحكمًا فيه بتجريداته الذهنية واستبدالاته الرمزية. تلكم هي الدعوى أو الفرضية الأساس التي يُحاجج لأجلها كل سميائي. وهي نفسها الدعوة التي نسوق لأجلها هذا البحث، على هدي خلفيةٍ معرفية نظرية، منطلقها السميائيات التأويلية، وموضوعها العلامة وسيرورة التدليل اللامتناهية. يهدف هذا البحث إذن، إلى رصد مكونات العلامات وآليات اشتغالها من منظور سميولساني، وذلك من خلال ثلاثة محاور: خُصِّص المحور الأول لبيان الخلفية المعرفية التي استندت إليها السميائيات التأويلية في بلورة التصور العام للعلامة. وخُصِّص المحوران الثاني والثالث للوقوف عند تفاصيل هذا التصور.
MACHINE LEARNING IN AGRICULTURE FOR CROP DISEASES IDENTIFICATION: A SURVEY
Authors: Kukadiya Hirenkumar , Meva Divyakant
Published: April 2023

The field of computer science known as machine learning is used to create algorithms that have the ability to self-learn or learn on their own. This is how the phrase "Machine Learning" came to be. Artificial intelligence in-cludes a subfield called machine learning. These days, machine learning and deep learning techniques are frequently used to classify and recognize leaf diseases. Recognizing leaf disease at an early stage is crucial in agricultural fields for all crops. Accurate disease detection at an early stage helps farmers boost production and their economy. The suggested study is a survey of more than 40 research papers that classify and identify plant leaf diseases using various machine learning and deep learning algorithms. It also discuss-es machine learning, its application to agriculture, as well as its benefits and drawbacks. Develop an automatic disease detection system for leaf disease classification and detection using web-based or mobile-based applications for future work. Using this survey to build a more accurate model for leaf disease classification and detection using machine learning with a wide range of datasets. This will be very beneficial for farmers to boost productivity and build their economies.
CONCEPTUAL FRAMEWORK ON SUCCESSFUL IMPLEMENTATION OF HYBRID WORK MODEL FOR VIRTUAL IT EMPLOYEES
Authors: G. Balamurugan , S. Priyanka
Published: April 2023

Recently, the hybrid work model—which blends on-site and remote employees—has grown in favour. This is primarily due to changes in job habits and technological advancements. A hybrid work approach offers employees more flexibility and a better work-life balance while maintaining the benefits of remote employment. The hybrid work paradigm offers opportunities for increased productivity and job satisfaction, as well as a more exclusive work environment. With consideration for work-life balance, technology, and employee well-being, the primary objective of this research study is to analyse how a hybrid work model impacts virtual employees and how moonlighting affects the hybrid work model of their employees.
On the learning of multi-word units via flashcard applications
Authors: Barghamadi Maryam , Rogers James , Muller Amanda
Published: April 2023

Knowledge of multi-word units (MWUs) helps to facilitate communicative fluency and research of them has gained more and more attention in recent years in regard to teaching methods and designing materials for second language (L2) acquisition. Incidental and intentional vocabulary learning are two dominant approaches to acquiring MWUs. In lexical studies, much research has examined the effects of these methods in various contexts. However, a gap in the research remains in regard to materials development. This study aims to discuss various interventions that affect the teaching and learning of MWUs. This paper will highlight how more exposure and focusing learners’ attention on particular MWUs is essential to efficient acquisition of MWUs fluency, and that this can be achieved through intentional learning activities such as the use of appropriately designed specialist digital flashcard-style computer applications. Specifically, pedagogical implications are discussed when such applications employ either spaced repetition or a Leitner algorithm.
Review of Routledge Handbook of Corpus Approaches to Discourse Analysis
Authors: Alghazo Sharif
Published: April 2023

Routledge Handbook of Corpus Approaches to Discourse Analysis edited by Eric Friginal and Jack A. Hardy, Routledge, 2021, 662pp., $250.00 (Hardcover). ISBN 9780367201814.
Language, diversity and culturally responsive education
Authors: Lopez Ann E.
Published: April 2023

Advanced economies are experiencing demographic shifts brought about by increased immigration. There are more students in schools who speak a language other than English. This has placed dialogue with regards to language diversity at the center of educational discourse. This conceptual article examines notions of identity and language within a poststructural framework and explores strategies that culturally responsive and social justice educators can employ to support emerging bilinguals (EBs) in diverse contexts. Grounded within an equity and social justice framework this articles uggests that teachers must be prepared to teach in culturally affirming and transformative ways to support emerging bilinguals.
Multicultural education: How are ethnic minorities labelled and educated in post-handover Hong Kong?
Authors: Gao Fang , Gube Jan
Published: April 2023

Using multicultural education as a lens, this article details the discursive formation of Hong Kong’s linguistic landscape with a focus on policy arrangements around teaching Chinese as a second language for non-Chinese ethnic minorities since the early 2000s. We pose two research questions: What are the identifiable policy trends in education for ethnic minorities? And how effective are the policy provisions in managing diversity and social justice for ethnic minorities in Hong Kong? The study draws upon documentary analysis to review existing local literature, which highlight the school admission, curriculum design, language teachers’ professional development practices, and assessment pertaining to the education of ethnic minority students. Our analysis reveals a narrow concentration of policies that focus exclusively on supporting ethnic minority students’ Chinese language learning regarded as the barrier to their advancement in education and an omission of other nonlinguistic, structural and ideological challenges and barriers. This barrier contributes to prejudices in school access, curriculum and assessment that function within an assimilationist integration framework. We call for policy measures that broaden the focus of multicultural education for ethnic minorities and that seek to manage ethnolinguistic diversity for equal citizenship rights in the Asian context.
Towards sustainable internationalization in post-COVID higher education: Voices from non-native English-speaking international students in Canada
Authors: King Phoebe
Published: April 2023

International students have been a dominant topic in Canadian government and institutional strategies in recent years (Tamtik, 2017; Trilokekar & El Masri, 2020). As of 2019, the Canadian Bureau of International Education (CBIE) reports over 600,000 international students in Canada across all levels of study. In the midst of the COVID-19 pandemic, the complexities around student engagement, learning and community building are complicated by remote learning. International students, in particular, face increasing challenges due to isolation from home countries and a reduction of in-person support services. We must now, more than ever, identify and address the lack of supports available to international students. This qualitative study provides voices from non-native English-speaking international students in Ontario universities speaking about the institutional support systems they have experienced in Canada. The findings are reported in a narrative format.
THE EFFECTIVENESS OF THE PERSON CENTERED COUNSELING APPROACH IN FOSTERING STUDENT LEARNING INDEPENDENCE (LITERATURE REVIEW)
Authors: Aprila Ana , Lestari Luh Putu Sri , Suranata Kadek , Juhani Sefrianus
Published: April 2023

One of the characteristics of the independent learning curriculum is student-centered learning. Students become a reference in finding patterns of learning and mentoring. In this context, teachers are required to seek power and efforts to foster the capability of students (student agency) in leading themselves. One pattern of assistance used by teachers, especially Counseling Guidance teachers is person-centered counseling. This research aims to determine the effectiveness of the Person-Centered counseling approach pattern in fostering student learning independence. The method used in this research is a systematic literature review. The stages in this method are planning, conducting, and reporting. The locus of this research is the literature research results of several researchers, who examined several schools related to the person-centered counseling approach. The results of this research are an increase in student independence in learning when the teacher applies a person-centered counseling pattern. This has been proven in several studies. On that basis, the application of the person-centered counseling approach model is something that is definitely needed to improve the quality of student learning.
플라이트와 스톱의 동시 발생이 경제 성장과 투자에 미치는 영향: 신흥 시장의 증거를 중심으로
Authors:   Institute of East and West Studies Yonsei University, Suh Jaehyun
Published: April 2023

This paper attempts to investigate if a significant increase in foreign asset purchases by domestic investors(i.e., a flight) is detrimental to emerging markets’ growth and investment using a panel data set that covers 56 emerging markets between 1990 and 2014. Furthermore, it studies the effect of a flight when it occurs simultaneously with a significant decrease in domestic asset purchases by foreign investors(i.e., a stop) using an interaction model. A key difference of our study is that we estimate this interaction effect using three generalized method of moments estimators(difference GMM, system GMM, and orthogonal deviation GMM) to address the causal effects rather than the associations between them. The results suggest that a flight alone is not harmful whereas simultaneous flights and stops could depress growth and investment. Therefore, the results of this paper complement the empirical evidence of the existing literature.
Kajian Penerapan Kebijakan Kawasan Pertanian Pangan Berkelanjutan di Daerah Kota Bandung
Authors: Mahardika Galih , Syaodih Ernady , Chofyan Ivan
Published: April 2023

Laju alih fungsi lahan pertanian menjadi lahan non pertanian di Kota Bandung semakin tinggi, yang tidak saja mengancam ketahanan pangan, tetapi juga mengakibatkan penurunan kualitas lingkungan. Menindaklajuti penerapan Undang Undang Nomor 41 tahun 2009 tentang Perlindungan Lahan Pertanian Pangan Berkelanjutan, perlu dibuat Kajian Penerapan Kebijakan Kawasan Pertanian Pangan Berkelanjutan (KP2B) di Daerah Kota (Studi Kasus: Kota Bandung). Arahan kebijakan KP2B Kota Bandung sudah terdapat Peraturan Daerah Nomor 18 Tahun 2011 Tentang Rencana Tata Ruang Wilayah Kota Bandung Tahun 2011-2031 yaitu mempertahankan kawasan pertanian tanaman pangan melalui intensifikasi lahan pertanian di 3 kecamatan. Namun belum eksplisit menyebutkan KP2B, detail lokasi dan luasannya baru berupa arahan kecamatan.  Penelitian ini menggunakan metoda Analisa overlay dan SWOT. Dari hasil analisa overlay Kecamatan Mandalajati tidak dapat lagi dimasukan kedalam usulan KP2B karena sudah beralih fungsi menjadi Lahan Pemakaman. Lokasi KP2B yang sesuai dan dapat dipertahankan adalah yang berlokasi di Kecamatan Ujung Berung dan Kecamatan Cibiru. Diperlukan penetapan Kawasan pertanian pangan berkelanjutan (KP2B) secara eksplisit dalam batang tubuh maupun peta perda Revisi RTRW Kota Bandung agar memiliki kekuatan hukum.
Evaluasi Kinerja Kawasan Agrowisata Ciwidey di Kabupaten Bandung
Authors: Hilman Dirapratama  , Hendrakusumah Ernawati , Pranggono Bambang
Published: April 2023

Perkembangan Kabupaten Bandung memperlihatkan kecenderungan pariwisata untuk menjadi andalan khususnya dalam menghasilkan pendapatan daerah. Pada kurun waktu 2014-2017 terjadi peningkatan jumlah wisatawan kurang lebih sebesar 1,1 juta wisatawan tiap tahunnya. Ini menandakan bahwa Kabupaten Bandung merupakan salah satu tujuan wisata yang menarik bagi wisatawan domestik maupun mancanegara. Salah satu potensi wisata di Kabupaten Bandung adalah Kawasan Agrowisata Ciwidey. Namun kawasan tersebut belum tergarap potensi wisatanya secara optimal, sehingga belum dapat memberikan kontribusi yang signifikan terhadap pertumbuhan dan pembangunan perekonomian di Kabupaten Bandung. Tujuan dari penelitian ini adalah untuk mengidentifikasi kondisi kinerja pengembangan Kawasan Agrowisata Ciwidey, untuk mengevaluasi penerapan konsep ideal agrowisata yang dapat mendukung pengembangan Kabupaten Bandung, dan untuk mengidentifikasi kendala apa saja yang mempengaruhi pengembangan kawasan Agrowisata Ciwidey. Adapun hasil dari penelitian ini bahwa Dinas Pariwisata dan Kebudayaan Kabupaten Bandung sudah berupaya dengan optimal dan telah berhasil melaksanakan program dan kegiatan sesuai dengan rencana yang telah di tetapkan sebelumnya, meskipun tidak secara spesifik menyasar pada pengembangan Kawasan Agrowisata Ciwidey. Terlihat dari prosentase tingkat pencapaian target sasaran dengan nilai melebihi apa yang telah di targetkan.
Penilaian Kualitas Aset Fasilitas Hutan Kota Patriot Bina Bangsa Bekasi
Authors: Melati Realita  , Angestiwi Tiafahmi
Published: April 2023

Hutan Kota Bekasi merupakan salah satu Ruang Terbuka Hijau (RTH) yang dikembangkan oleh Pemerintah Kota Bekasi melalui Dinas Lingkungan Hidup dengan luas 42.673 m2. Kawasan Hutan Kota Patriot Bina Bangsa Bekasi ditetapkan berdasarkan Surat Keputusan Walikota Bekasi Nomor: 032/Kep.459-BPKAD/XI/2012 difungsikan sebagai resapan air dan plasma nutfah, lokasi wisata, dan pusat aktifitas masyarakat. Berdasarkan observasi pendahuluan kondisi eksisting Hutan Kota Bekasi memiliki berbagai indikasi masalah yaitu pengguna yang kesusahan untuk menemukan toilet umum, fasilitas olahraga dan bermain anak yang sudah rapuh dan karat bahkan ada yang sudah patah dan tidak dapat digunakan padahal tiap sore banyak pemuda pemudi yang mengunjungi Hutan Kota sebagai tempat olahraga maupun rekreasi, keadaan Hutan Kota disaat malam ataupun menjelang malam sangat rawan karena kurangnya lampu penerangan disekitar area Hutan Kota. Tujuan penelitian ini adalah untuk menilai kualitas aset fasilitas Hutan Kota Bekasi berdasarkan fasilitas pelayanan untuk pengguna, tingkat aktivitas, tingkat kebermaknaan, dan kemudahan akses. Metode penelitian yang digunakan adalah metode deskriptif dengan pendekatan kualitatif dan kuantitatif. Teknik pengumpulan data yang digunakan yakni observasi ilmiah, wawancara, dan angket/kuesioner dengan teknik analisis statistik deskriptif. Hasil penelitian ini menunjukkan bahwa berdasarkan dimensi pelayanan untuk pengguna cukup, dimensi tingkat aktivitas cukup, dimensi tingkat kebermaknaan baik, dan dimensi kemudahan akses baik. Sehingga rekomendasi yang diberikan yaitu dilakukannya pengembangan aset fasilitas di Hutan Kota Patriot Bina Bangsa Bekasi
RESPONSABILIDADE CIVIL AMBIENTAL: BREVES CONSIDERAÇÕES SOBRE A (IN)APLICABILIDADE DA TEORIA DO RISCO INTEGRAL
Authors: MACIEIRA Ricardo Felipe Rodrigues , LOPES Marco Túlio Rodrigues
Published: April 2023

O artigo analisa a teoria do risco integral enquanto fundamento da responsabilidade civil objetiva e os problemas relativos à sua aplicação no âmbito do Direito Ambiental, particularmente nos casos de responsabilização do poluidor indireto e naqueles decorrentes de acidente nuclear. O texto investiga os aspectos fundamentais da responsabilidade civil, a partir da noção de culpa jurídica como seu elemento central, o desenvolvimento do modelo objetivo de responsabilidade e a adoção da teoria do risco como um de seus possíveis
fundamentos, especialmente a modalidade do risco integral. Abordam-se, em seguida, o desenvolvimento da responsabilidade civil ambiental, o acolhimento da teoria do risco integral como base desse modelo e a questão relativa à sua aplicabilidade ao chamado poluidor indireto e ao dano provocado por acidente nuclear. A finalidade é tentar compreender sua recepção pelo ordenamento jurídico brasileiro e os limites de sua aplicação, mercê do posicionamento consolidado na jurisprudência do Superior Tribunal de Justiça e de seu acolhimento pela doutrina de forma predominante.

Palavras-chave: Responsabilidade ambiental. Responsabilidade objetiva. Risco integral. Poluidor indireto. Dano nuclear.
PBL, TBL E ABP NA FORMAÇÃO DE PROFISSIONAIS DA SAÚDE: REVISÃO DE LITERATURA
Authors: SOUSA Carlos Eduardo Guerra Cunha
Published: April 2023

O ensino ocorre ao longo da vida inteira de um indivíduo, construindo um processo de educação permanente. Para uma boa formação é necessário que se aprenda a conhecer, aprenda a fazer, aprenda a conviver e aprenda a ser. Diante disso, desenvolvem-se métodos novos de ensino. Nessas metodologias, os educandos executam atividades que necessitam de reflexão de ideias e desenvolvimento da competência de emprega-las. Objetivo: O presente estudo tem como finalidade analisar os avanços nos meios de ensinoaprendizagem,
expor os principais conceitos, métodos e ferramentas das denominadas
metodologias ativas e destacar sua aplicação na formação de trabalhadores da saúde, visando a orientação de educadores. Métodos: Foi realizada uma revisão de literatura por meio de busca online na Biblioteca Virtual de Saúde (BVS), Scielo (Scientific Eletronic Library Online), Google Acadêmico, e PubMed. Resultados: Atualmente, há diversos mecanismos de ensino aprendizagem que são capazes de possibilitar uma aprendizagem efetiva e afetiva. Desta maneira, quaisquer formas de aprendizagem colaborativa ou/e ativa, centradas nos acadêmicos, sendo técnicas de ensino construtivistas, cumprem a esse objetivo. São exemplos de metodologias ativas a Aprendizagem Baseada em Problemas -PBL (ProblemBased Learning), Aprendizagem Baseada em Equipe - TBL (Team BasedLearning) e Aprendizagem Baseada em Projetos - ABP (Project Based Learning). Conclusões: Apesar das dificuldades encontradas na atual conjuntura educacional brasileira, a aprendizagem ativa possibilita o desenvolvimento pessoal e profissional dos sujeitos, quando ministrada com maestria.Profissionais da saúde, educados nesse método,são mais críticos e independentes.

Palavras-chave: Aprendizagem ativa. Ensino. Educação superior. Aprendizagem baseada em problemas. Educação em saúde.
ADOÇÃO HOMOAFETIVA E OS DESAFIOS DA FORMAÇÃO FAMILIAR
Authors: CANUTO Ancelmo Bessa , SANTOS Ítalo Danyel Amorim Gonçalves dos
Published: April 2023

Este artigo tem a finalidade de falar a respeito da adoção homoafetiva, e os desafios da formação familiar. Tendo em vista, que trata se de uma questão polêmica de pessoas do mesmo sexo, casais homoafetivos, que tentam por meios legais e também efeitos sobre o adotado. Pode se dizer que, constituir uma família atualmente, sofre por mudanças no decorrer dos tempos em toda estrutura e com essas mudanças, veio todo o surgimento de uma formação de famílias, onde estas trouxeram a possibilidade de crianças que vivem em casas de apoio, crianças que até então descrentes de serem adotadas, possam ter uma esperança onde as possibilita em formar uma família com afeto, respeito e amor. Pois, apesar da união homoafetiva, ser um tema bem pacificado, a adoção no Brasil, já realidade, porém, mesmo assim esses casais necessitam lutar utilizando-se de atos nomartivos e interpelação judicial, para que então consigam formar uma família, pois não se existe ainda uma lei que ampara legalmente os casais homoafetivos para a adoção onde expressa a
nossa legislação.

Palavras-chave: Adoção. Crianças. Família. Formação.
UMA ANÁLISE SOBRE A (DES) MOTIVAÇÃO DO ALUNO E DA INSTITUIÇÃO DO ENSINO SUPERIOR NO EXAME DO ENADE
Authors: OLIVEIRA Jocirley de , BRITO Hildeglan Carneiro de , MARINHO Tullio da Silva
Published: April 2023

No Brasil, o Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (Inep) é o responsável por promover estudos, pesquisas e avaliações sobre o sistema educacional do país. Dentre as várias avaliações que realiza, o Inep aplica o Exame Nacional de Desempenho de Estudantes (ENADE). A partir das análises dos dados produzidos pela aplicação desse exame, é possível observar o desempenho tanto do estudante quanto das
instituições e, assim, calcular indicadores de qualidade que, dentro de um contexto, oportunizarão decisões de melhorias do processo de ensino e aprendizagem. Este trabalho apresenta uma análise do exame com foco no processo de desmotivação e motivação apresentadas pelos estudantes e IES – Instituições de Ensino Superior no processo avaliativo. No que diz respeito à metodologia, a pesquisa foi bibliográfica e seguiu a abordagem qualitativa. Articulando as pesquisas realizadas, construíram-se reflexões sobre o tema. Chegou-se à conclusão que a maioria dos alunos não se sente motivada para realizarem o exame e as IES não conseguem demonstrar para os discentes o quanto é importante a participação no processo avaliativo.

Palavras-Chave: Enade. Desmotivação. Motivação.
A HISTÓRIA DA EDUCAÇÃO PARA PESSOAS COM DEFICIÊNCIA: ALGUNS APONTAMENTOS GERAIS
Authors: SILVA Josélia Maciel da
Published: April 2023

A educação para as pessoas com deficiência é uma luta que tem sido travada nos últimos anos dentro das instituições de ensino regular, processo este que encontra inúmeras barreiras nas instituições de ensino, desde a falta de materiais didáticos, profissionais qualificados, infraestrutura física, dentre outros aspectos. Diante disso, o artigo objetiva analisar a história da educação para pessoas com deficiência em um contexto geral, mostrando assim, todas as dificuldades encontradas no início dessa educação até os desafios de hoje que engloba não só a escola, mas também a sociedade e o Estado. A pesquisa pautou por uma discussão bibliográfica, baseada em teóricos e pesquisadores que deram sua contribuição para a construção do entendimento do fenômeno em questão, e abrindo possibilidades para discussões posteriores.

Palavras-chave: Educação especial. Pessoas com deficiência. História. Ensino regular.
A IMPORTÂNCIA DO BIODIREITO NA SAÚDE
Authors: SOUSA Savia Soares de , MILHOMEM Nádia Regina Stefanine
Published: April 2023

Com este artigo objetivou-se analisar a importância do biodireito na saúde e as técnicas utilizadas para modificar o material genético de células ou organismos, a fim de eliminar doenças genéticas ou hereditárias. A importância do tema, portanto, será mostrada à luz da bioética e do biodireito, visto que a bioética atuaria no sentido de propor formas de
manipulação genética que visem o bem-estar do ser humano, respeitando seus desejos, crenças e valores e o biodireito atuaria na positivação jurídica, permitindo ou proibindo condutas profissionais e criando limites ético-legais para evitar abuso. Serão analisados também todos os potenciais positivos e negativos desta técnica, como por exemplo, a importância da sociedade não ser indiferente a este tipo de estudo, tendo em vista que será a afetada pelos seus resultados, seja para o lado positivo ou negativo. Daí a importância de todos estarem cientes e preocupados com o bem envolvido, que é a vida humana, e deve ser protegida acima de tudo. Para o desenvolvimento do artigo, será utilizada pesquisa bibliográfica com busca em livros, artigos, jornais e embasamento nos conhecimentos disponíveis sobre o tema de estudo e suas teorias. O método utilizado será o dedutivo, pois partirá de espaços gerais, e logo após partirá para espaços específicos, a fim de concluir que é preciso que a bioética e o biodireito trabalhem em conjunto para que esta pesquisa seja utilizada de forma ética e que garanta o respeito à vida humana.

Palavras-chave: Bioética. Biodireito. Manipulação genética.
International Sign Language Sociolinguistic Aspects
Authors: Rathmann Christian , Quadros Ronice de
Published: April 2023

É uma publicação em Língua de Sinais internacional e inglês com questões sociolinguísticas
INGLES EAD NAS EMPRESAS
Authors: TADEU ROBERTA
Published: April 2023

No mundo atual, as grandes corporações encontram dificuldades na contratação de mão de
obra qualificada quanto ao uso de línguas estrangeiras, pois a taxa de brasileiros que
são fluentes na língua inglesa ainda é defasada.Com isso, o objetivo deste trabalho é
apresentar propostas de soluções para esta problemática.Como método, foi feita uma revisão
da literatura com trabalhos já publicados em revistas indexadas.Apesar de resultados
contraditóriso,o EAD mostrou-se mais acessível, tanto no aspecto financeiro como no aspecto
didático. Como conclusão,o EAD é uma boa opção de qualificação profissional, apesar de
suas deficiências. Porém, mais estudos são necessários para aprofundar essa nova
metodologia.
Factors motivating head teachers in Marakwet west Sub County to enroll for the KEMI diploma in educational management course
Authors: Benson Chege Njuguna  , Kitainge Kisilu  , Lydia Kipkoech
Published: April 2023

Head teachers of primary schools have to deal with a lot of shifting managerial environments, which sometimes makes them ineffective in their expanding responsibilities. Therefore, providing targeted in-service training has never been essential. Head teachers in Kenya's Marakwet West Sub County were asked to participate in the KEMI Diploma in Educational Management Course as part of this study. The research design was a descriptive survey. The sample consisted of 38 head teachers chosen through stratified random sampling from 57 schools whose heads had completed the KEMI Diploma in Education Management, 42 teachers chosen at random, and 13 chairpersons of the Board of Management chosen intentionally from the same schools. Data was gathered through the use of questionnaires. The information was summed up and introduced utilizing recurrence tables, charts and rates. The study found that head teachers were motivated by the need to improve their skills, a raise in pay, and a higher job grade. In order to encourage teachers to participate in useful professional development programs, the study suggested that head teachers' job evaluations include an audit of skill requirements, continuous short-term refresher courses in areas that were studied, decentralization of training, and recognition of head teachers' academic achievement through promotion and salary increments. The study found that there were gaps between the course content and the actual management skills that school managers need, such as ICT skills and financial management bookkeeping. The TSC's selection, promotion, and deployment of head teachers of primary schools should also be reviewed, according to the study.
Content validity and reliability of the adult attachment interview in a sample of Moroccan young adults
Authors: Fatima Attar  , Khadija Ouadi
Published: April 2023

The aim of this study was to adapt and validate the Adult Attachment Interview (AAI), relying on content validity of the AAI, using discourse analysis and test-retest reliability as proposed in the literature. We hypothesized that participants with the same attachment style would use similar semantic systems, and that people who belong to different categories of attachment would use divergent semantic systems. Overall, 20 participants volunteered to take part in this research. The interviews were transcripted, coded and classified following the AAI protocol instructions, relying on the classification and coding system manual. We created a textual corpus composed of the interview transcripts. Each interview was analyzed manually. Of the 20 interviews, 35% were classified as secure attachment style, 50% a dismissing style, 15% and a preoccupied style. The reliability of the AAI classifications was quite high (75%).Results confirmed the relationship between attachment category and representations, In particular, the secure participants tend to be metacognitive, distinguished by a coherent mind and transcript, while dismissive participants exhibited to idealization, passivity of thought and inability to recall, and preoccupied participants prone to an incoherence of mind and transcript, due to their indulgence in talking about the memories of the past, which are still present with all their emotional charge.
Rethinking the Authorship of Contemporary Art in Copyright Law: Chance·Indeterminacy Music as a Case Study
Authors:   Korea Copyright Commission, Seo Jun-Hyeok
Published: April 2023

This study focuses on the concept of the ‘author’ in copyright law, particularly in the context of chance and indeterminacy music, where the composer intentionally excludes their authorship from the work. In copyright law, ‘creation’, required to become an author is generally understood as the act of “concretizing a particular idea or emotion into a creative external expression.” Applying this concept to chance and indeterminacy music, it caused the legal problem of denying the work’s copyrightability or destabilizing the traditional status of the author. Re-examining this through the theory of copyright justification, it was pointed out that the legal problem cannot be merged with the justification of the copyright system. Fundamentally, the limitation of the “idea-expression dichotomy” principle, a premise to the concept of the creator, was identified. Raising doubts as to whether it is truly valid for this principle to play a major role in the concept of the creator, this study proposed the application of Balganesh’s copyrightable causation theory as an alternative, and concluded that a normative judgment criterion must be used to determine whether a work qualifies as “creation” in order for law and art to be harmonized.
KAJIAN TEKNIS BUDIDAYA IKAN KAKAP PUTIH (Lates calcarifer) DI BALAI PERIKANAN BUDIDAYA AIR PAYAU (BPBAP) SITUBONDO, KABUPATEN SITUBONDO, JAWA TIMUR
Authors: Astuti Endang Puji , A'yun Qurrota , Vitasari Arida , Sari Putri Desi Wulan
Published: April 2023

White snapper (Lates calcarifer) is a marine fish that can be referred to as giant sea perch, sea bass, and barramundi. This fish is one of the fishery commodities that have many overseas enthusiasts. The characteristics of fish are that they are easy to cultivate because they grow relatively fast and can adapt well to the environment. However, in the process of cultivation, seeds have low susceptibility to diseases caused by environmental conditions. The solution to overcome this is to improve the quality of the parent and seed. Furthermore, the seeds are cultivated until they reach the consumption size to meet market needs. The purpose of writing this scientific article for street vendors is to find out the cultivation techniques of white snapper at the BPBAP Situbondo Fisheries Center, as well as the problems that occur during cultivation activities. The method used was the active participation method and observation. White snapper cultivationtechniques include broodstock maintenance, hatchery, and rearing, each of which consists of pond preparation, feeding, monitoring water quality, and monitoring pests and diseases. The results of observations obtained from parent-rearing activities were 79% FR, hatchery activities obtained 50% HR and 22% SR, and rearing activities with 0.10% SGR, 4.29 FCR, and 54.43% SR. The obstacle that occurs is the presence of human error in the hatchery unit due to delays in grading, causing low survival rates (SR) that do not meet the requirements. In addition, the rearing unit trash feed is not always available so it does not meet the requirements in the calculation of SR, SGR, and FCR.