bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasound characteristics of follicular and parafollicular thyroid neoplasms: diagnostic performance of artificial neural network
Authors: Cordes Michael , Götz Theresa Ida , Coerper Stephan , Kuwert Torsten , Schmidkonz Christian
Published: August 2023

Background

Ultrasound is the first-line imaging modality for detection and classification of thyroid nodules. Certain features observable by ultrasound have recently been equated with potential malignancy. This retrospective cohort study was conducted to test the hypothesis that radiomics of the four categorical divisions (medullary [MTC], papillary [PTC], or follicular [FTC] carcinoma and follicular thyroid adenoma [FTA]) demonstrate distinctive sonographic characteristics. Using an artificial neural network model for proof of concept, these sonographic features served as input.

Methods

A total of 148 patients were enrolled for study, all with confirmed thyroid pathology in one of the four named categories. Preoperative ultrasound profiles were obtained via standardized protocols. The neural network consisted of seven input neurons; three hidden layers with 50, 250, and 100 neurons, respectively; and one output layer.

Results

Radiomics of contour, structure, and calcifications differed significantly according to nodule type (p = 0.025, p = 0.032, and p = 0.0002, respectively). Levels of accuracy shown by artificial neural network analysis in discriminating among categories ranged from 0.59 to 0.98 (95% confidence interval [CI]: 0.57–0.99), with positive and negative predictive ranges of 0.41–0.99 and 0.78–0.97, respectively.

Conclusions

Our data indicate that some MTCs, PTCs, FTCs, and FTAs have distinctive sonographic characteristics. However, a significant overlap of these characteristics may impede an explicit classification. Further prospective investigations involving larger patient and nodule numbers and multicenter access should be pursued to determine if neural networks of this sort are beneficial, helping to classify neoplasms of the thyroid gland.
Opening of Cx43-formed hemichannels mediates the Ca2+ signaling associated with endothelial cell migration
Authors: Espinoza Hilda , Figueroa Xavier F.
Published: August 2023

Endothelial cell migration is a key process in angiogenesis. Progress of endothelial cell migration is orchestrated by coordinated generation of Ca2+ signals through a mechanism organized in caveolar microdomains. Connexins (Cx) play a central role in coordination of endothelial cell function, directly by cell-to-cell communication via gap junction and, indirectly, by the release of autocrine/paracrine signals through Cx-formed hemichannels. However, Cx hemichannels are also permeable to Ca2+ and Cx43 can be associated with caveolin-1, a structural protein of caveolae. We proposed that endothelial cell migration relies on Cx43 hemichannel opening. Here we show a novel mechanism of Ca2+ signaling in endothelial cell migration. The Ca2+ signaling that mediates endothelial cell migration and the subsequent tubular structure formation depended on Cx43 hemichannel opening and is associated with the translocation of Cx43 with caveolae to the rear part of the cells. These findings indicate that Cx43 hemichannels play a central role in endothelial cell migration and provide new therapeutic targets for the control of deregulated angiogenesis in pathological conditions such as cancer.
3DDPDs: describing protein dynamics for proteochemometric bioactivity prediction. A case for (mutant) G protein-coupled receptors
Authors: Gorostiola González Marina , van den Broek Remco L. , Braun Thomas G. M. , Chatzopoulou Magdalini , Jespers Willem , IJzerman Adriaan P. , Heitman Laura H. , van Westen Gerard J. P.
Published: August 2023

Proteochemometric (PCM) modelling is a powerful computational drug discovery tool used in bioactivity prediction of potential drug candidates relying on both chemical and protein information. In PCM features are computed to describe small molecules and proteins, which directly impact the quality of the predictive models. State-of-the-art protein descriptors, however, are calculated from the protein sequence and neglect the dynamic nature of proteins. This dynamic nature can be computationally simulated with molecular dynamics (MD). Here, novel 3D dynamic protein descriptors (3DDPDs) were designed to be applied in bioactivity prediction tasks with PCM models. As a test case, publicly available G protein-coupled receptor (GPCR) MD data from GPCRmd was used. GPCRs are membrane-bound proteins, which are activated by hormones and neurotransmitters, and constitute an important target family for drug discovery. GPCRs exist in different conformational states that allow the transmission of diverse signals and that can be modified by ligand interactions, among other factors. To translate the MD-encoded protein dynamics two types of 3DDPDs were considered: one-hot encoded residue-specific (rs) and embedding-like protein-specific (ps) 3DDPDs. The descriptors were developed by calculating distributions of trajectory coordinates and partial charges, applying dimensionality reduction, and subsequently condensing them into vectors per residue or protein, respectively. 3DDPDs were benchmarked on several PCM tasks against state-of-the-art non-dynamic protein descriptors. Our rs- and ps3DDPDs outperformed non-dynamic descriptors in regression tasks using a temporal split and showed comparable performance with a random split and in all classification tasks. Combinations of non-dynamic descriptors with 3DDPDs did not result in increased performance. Finally, the power of 3DDPDs to capture dynamic fluctuations in mutant GPCRs was explored. The results presented here show the potential of including protein dynamic information on machine learning tasks, specifically bioactivity prediction, and open opportunities for applications in drug discovery, including oncology.
Self-disgust in patients with borderline personality disorder. The associations with alexithymia, emotion dysregulation, and comorbid psychopathology
Authors: Kot Emilia , Kostecka Barbara , Radoszewska Joanna , Kucharska Katarzyna
Published: August 2023

Background

Self-disgust is a negative self-conscious emotion, which has been linked with borderline personality disorder (BPD). However, it has not yet been investigated in relation to both emotion dysregulation and alexithymia, which are recognized as crucial to BPD. Therefore, the aim of our study was to measure these variables and examine the possible mediational role of emotional alterations and comorbid anxiety and depression symptoms in shaping self-disgust in patients with BPD and healthy controls (HCs).

Methods

In total, the study included 100 inpatients with BPD and 104 HCs. Participants completed: the Self-Disgust Scale (SDS), Disgust Scale – Revised (DS-R), Toronto Alexithymia Scale (TAS-20), Emotion Dysregulation Scale short version (EDS-short), Borderline Personality Disorder Checklist (BPD Checklist), State-Trait Anxiety Inventory (STAI), and Center for Epidemiologic Studies Depression Scale (CESD-R).

Results

Inpatients with BPD showed higher self-disgust, alexithymia, emotion dysregulation, core and comorbid symptoms levels, and lower disgust sensitivity. Alexithymia, emotion dysregulation, and trait anxiety partially mediated between BPD diagnosis and self-disgust. The relationship between the severity of BPD symptoms and self-disgust was fully mediated by alexithymia, emotion dysregulation, depressive symptoms, and trait anxiety.

Conclusions

The results of our study may imply the contribution of emotion dysregulation, alexithymia, and comorbid psychopathology to self-referenced disgust in BPD.
Artificial intelligence in intelligent tutoring systems toward sustainable education: a systematic review
Authors: Lin Chien-Chang , Huang Anna Y. Q. , Lu Owen H. T.
Published: August 2023

Sustainable education is a crucial aspect of creating a sustainable future, yet it faces several key challenges, including inadequate infrastructure, limited resources, and a lack of awareness and engagement. Artificial intelligence (AI) has the potential to address these challenges and enhance sustainable education by improving access to quality education, creating personalized learning experiences, and supporting data-driven decision-making. One outcome of using AI and Information Technology (IT) systems in sustainable education is the ability to provide students with personalized learning experiences that cater to their unique learning styles and preferences. Additionally, AI systems can provide teachers with data-driven insights into student performance, emotions, and engagement levels, enabling them to tailor their teaching methods and approaches or provide assistance or intervention accordingly. However, the use of AI and IT systems in sustainable education also presents challenges, including issues related to privacy and data security, as well as potential biases in algorithms and machine learning models. Moreover, the deployment of these systems requires significant investments in technology and infrastructure, which can be a challenge for educators. In this review paper, we will provide different perspectives from educators and information technology solution architects to connect education and AI technology. The discussion areas include sustainable education concepts and challenges, technology coverage and outcomes, as well as future research directions. By addressing these challenges and pursuing further research, we can unlock the full potential of these technologies and support a more equitable and sustainable education system.
Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells
Authors: Wang Xin , Zhang Yongtao , Wang Dongdong , Su Ning , Yang Li , Fu Hao , Zhang Jiachan , Li Meng , Wang Changtao
Published: August 2023

Background

Aureobasidium pullulans (A. pullulans) has a wide range of applications. Ultraviolet (UV) rays from the sun can cause skin photoaging. In order to explore the protective effect and application potential of A. pullulans lysate on UV-damaged human skin fibroblasts (HSF) and HaCaT Cells, this study investigates the anti-aging and anti-inflammatory effects of A. pullulans lysate as well as the mechanism of anti-oxidative stress at the cellular and molecular levels through cytotoxicity experiments, enzyme-linked immunosorbent assays (ELISA), and real-time quantitative PCR (RT-qPCR).

Results

The experimental results have shown that the A. pullulans lysate can effectively reduce the loss of extracellular matrix components (EMC), such as collagen and hyaluronic acid (HA). It is also capable of scavenging excess reactive oxygen species (ROS) from the body, thereby increasing the activity of catalase, decreasing the overexpression of intracellular matrix metalloproteinases (MMPs), enhancing the gene expression of metalloproteinase inhibitors (TIMPs), and decreasing the level of inflammatory factors, reducing UV-induced apoptosis of HaCaT cells. Meanwhile, oxidative stress homeostasis is also regulated through the Nrf2/Keap1 and MAPK signaling pathways.

Conclusions

This study shows that the A. pullulans lysate has the potential to resist photoaging.

Graphical Abstract
Acute peritonitis caused by the acute pancreatitis of an ectopic pancreas in a jejunal duplication, in an adult with intestinal malrotation: a case report
Authors: Yoshikawa Chihiro , Migita Kazuhiro , Yamato Ichiro , Ueno Masato , Kashizuka Hisanori , Murakami Koichi , Ishikawa Hirofumi
Published: August 2023

Background

Intestinal duplication and ectopic pancreas are two rare independent congenital anomalies. Few reports describe cases of patients with ectopic pancreas in an intestinal duplication causing acute peritonitis.

Case presentation

A 31-year-old man was admitted to the hospital for epigastric pain. The patient was diagnosed with acute peritonitis caused by the acute pancreatitis of an ectopic pancreas in a jejunal duplication, with intestinal malrotation. The patient underwent the partial resection of the jejunum and Ladd’s procedure. The histopathological findings indicated ectopic pancreatitis in the jejunal duplication.

Conclusions

We presented the case of acute peritonitis caused by the acute pancreatitis of an ectopic pancreas in a jejunal duplication in an adult with intestinal malrotation. Surgery is the primary treatment and is necessary for a definitive diagnosis.
Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment
Authors: Lee Eun Sook , Ko Hyewon , Kim Chan Ho , Kim Hyun-Chul , Choi Seong-Kyoon , Jeong Sang Won , Lee Se-Guen , Lee Sung-Jun , Na Hee-Kyung , Park Jae Hyung , Shin Jung Min
Published: August 2023

Background

Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy.

Main body

Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges.

Conclusion

This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment.

Graphical Abstract
Diversified caregiver input to upgrade the Young Children’s Participation and Environment Measure for equitable pediatric re/habilitation practice
Authors: Villegas Vivian C. , Bosak Dianna L. , Salgado Zurisadai , Phoenix Michelle , Parde Natalie , Teplicky Rachel , Khetani Mary A. ,   High Value Early Intervention Research Group, Kuznicki L. , Pedrow A. , Howell A.
Published: August 2023

Background

Practitioner and family experiences of pediatric re/habilitation can be inequitable. The Young Children’s Participation and Environment Measure (YC-PEM) is an evidence-based and promising electronic patient-reported outcome measure that was designed with and for caregivers for research and practice. This study examined historically minoritized caregivers’ responses to revised YC-PEM content modifications and their perspectives on core intelligent virtual agent functionality needed to improve its reach for equitable service design.

Methods

Caregivers were recruited during a routine early intervention (EI) service visit and met five inclusion criteria: (1) were 18 + years old; (2) identified as the parent or legal guardian of a child 0–3 years old enrolled in EI services for 3 + months; (3) read, wrote, and spoke English; (4) had Internet and telephone access; and (5) identified as a parent or legal guardian of a Black, non-Hispanic child or as publicly insured. Three rounds of semi-structured cognitive interviews (55–90 min each) used videoconferencing to gather caregiver feedback on their responses to select content modifications while completing YC-PEM, and their ideas for core intelligent virtual agent functionality. Interviews were transcribed verbatim, cross-checked for accuracy, and deductively and inductively content analyzed by multiple staff in three rounds.

Results

Eight Black, non-Hispanic caregivers from a single urban EI catchment and with diverse income levels (Mdn = $15,001–20,000) were enrolled, with children (M = 21.2 months, SD = 7.73) enrolled in EI. Caregivers proposed three ways to improve comprehension (clarify item wording, remove or simplify terms, add item examples). Environmental item edits prompted caregivers to share how they relate and respond to experiences with interpersonal and institutional discrimination impacting participation. Caregivers characterized three core functions of a virtual agent to strengthen YC-PEM navigation (read question aloud, visual and verbal prompts, more examples and/or definitions).

Conclusions

Results indicate four ways that YC-PEM content will be modified to strengthen how providers screen for unmet participation needs and determinants to design pediatric re/habilitation services that are responsive to family priorities. Results also motivate the need for user-centered design of an intelligent virtual agent to strengthen user navigation, prior to undertaking a community-based pragmatic trial of its implementation for equitable practice.
Novel composite membrane based on recycled low-density polyethylene-alumina used for vacuum membrane distillation
Authors: Hanen Ajari , Fatma Khaled , Hiba Akrout , Khaoula Hidouri , Béchir Chaouachi , Qusay Alsalhy
Published: August 2023

Background

Plastic materials have a significant impact on the entire environment. Very relevant ideas in different areas with the aim of enhancing these materials and making them effective in our daily lives. In this context, our work in this article by using plastic materials in the manufacture of hydrophobic membranes realized in our Laboratory LEEP Enig Gabes Tunisia, followed by various analyses. These membranes are made of a Recycled Low-Density Polyethylene polymer by means of the Thermal Induced Phase Separation (TIPS) method by using solvents such as Butyl Acetate, non-solvent Hexane with the addition of Alumina at different concentrations to increase porosity.

Results

Hydrophobic membranes are coupled to the vacuum still to test their performance. An analytical study by FTIR was done. Contact angle, pore size, porosity, mechanical test, bubble point pressure, AFM and SEM analysis. The results revealed that the addition of alumina had an important role in improving the structure, properties and therefore the performance of the membrane.

Conclusions

The membrane already prepared admits according to the analyzes tested a good porosity, hydrophobicity.
Is triple antithrombotic therapy a safe option in patients with AF who receive drug-eluting stents?: a review article
Authors: Alshahrani Ali , O’Nunain Sean
Published: August 2023

Background

Optimal antithrombotic therapy depicts a challenge to clinicians treating atrial fibrillation (AF) patients who are undergoing percutaneous coronary intervention (PCI). Theoretically, these patients would require a combination therapy of oral anticoagulant and dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor, known as triple antithrombotic therapy (TAT). However, TAT is known to carry a significant risk of bleeding. The purpose of the present paper is to provide a focused review of the evidence about the safety of TAT as well as to address contemporary directions regarding antithrombotic therapy following PCI in patients with AF who received a drug-eluting stent.

Main body

Novel oral anticoagulant studies consistently demonstrated a better safety profile when compared to Vitamin K antagonist (warfarin), especially in AF patients who have other indications of DAPT after PCI. Evidence from several studies showed that the use of TAT in AF patients undergoing stent implantation or PCI has no significant clinical benefit with more risk of major bleeding when compared to DAT. Therefore, the current recommendations for AF have taken into account the mounting evidence of antithrombotic treatment after PCI in AF patients, which has caused a major shift away from the TAT strategy toward DAT over time.

Conclusions

Cardiologists face challenges in determining the best antithrombotic treatment for AF patients after PCI with DES implantation. Growing data suggest that TAT is associated with considerable bleeding and worse safety, without significant effectiveness. Hence, TAT is strictly applied for individuals with significant thrombotic risk and low bleeding risk, and for a limited duration. This paper highlights the safety concerns of TAT and current trends in antithrombotic therapy after PCI in patients with AF and DES.
Cross-platform comparison of precision and time effectiveness of automated versus semi-automated brain volumetric measurements in healthy Egyptian adults
Authors: Hassan Abdallah Adel Abdallah , Azab Amr Osama , Ahmed Habeba Mostafa , Mohamed Lena Mohamed Abdel Monem , Adel Mohamed , El-Basmy Ayman A.
Published: August 2023

Background

The primary goal of this study is to evaluate the precision, time effectiveness and reproducibility of open source automated magnetic resonance imaging (MRI) brain volumetric measurement platforms as compared to the semi-automated methods. The secondary goal of the study is to create age-stratified database of MRI brain volumetric measures of healthy Egyptian adults.

Results

Statistically significant variation were found between the absolute but not the relative volumetric measures (P-value < 0.001). Both the absolute and relative global volumetric measures were strongly correlated with age. Only the absolute volumes showed strong correlation with gender with male volumes being significantly higher than females (P-value < 0.0001), while the normative ratio correlation with gender varied with the utilized software.

Conclusions

FMRIB's software library automated segmentation tool (FSL-FAST) was considered the most efficient program to run global volumetric analysis, unless concurrent advanced volumetric analysis is needed or gray matter volume is the main objective of the volumetric analysis, then FreeSurfer is considered the most efficient volumetric software.
Confocal nonlinear optical imaging on hexagonal boron nitride nanosheets
Authors: Lee Gwanjin , Jyothsna Konkada Manattayil , Park Jonghoo , Lee JaeDong , Raghunathan Varun , Kim Hyunmin
Published: August 2023

Optical microscopy with optimal axial resolution is critical for precise visualization of two-dimensional flat-top structures. Here, we present sub-diffraction-limited ultrafast imaging of hexagonal boron nitride (hBN) nanosheets using a confocal focus-engineered coherent anti-Stokes Raman scattering (cFE-CARS) microscopic system. By incorporating a pinhole with a diameter of approximately 30 μm, we effectively minimized the intensity of side lobes induced by circular partial pi-phase shift in the wavefront (diameter, d0) of the probe beam, as well as nonresonant background CARS intensities. Using axial-resolution-improved cFE-CARS (acFE-CARS), the achieved axial resolution is 350 nm, exhibiting a 4.3-folded increase in the signal-to-noise ratio compared to the previous case with 0.58 d0 phase mask. This improvement can be accomplished by using a phase mask of 0.24 d0. Additionally, we employed nondegenerate phase matching with three temporally separable incident beams, which facilitated cross-sectional visualization of highly-sample-specific and vibration-sensitive signals in a pump-probe fashion with subpicosecond time resolution. Our observations reveal time-dependent CARS dephasing in hBN nanosheets, induced by Raman-free induction decay (0.66 ps) in the 1373 cm−1 mode.
Gymnema sylvestre as a potential therapeutic agent for PCOS: insights from mRNA differential gene expression and molecular docking analysis
Authors: Vora Divya , Kapadia Hardi , Dinesh Susha , Sharma Sameer , Manjegowda Dinesh Sosalagere
Published: August 2023

Background

In spite of the increased prevalence of Polycystic Ovary Syndrome in bilateral ovaries (PCOS) in females globally (~ 20%), the rate of decisive treatment is limited due to late and invasive diagnostics and the unavailability of stand-alone drugs against phenotypic symptoms associated with PCOS. This study aims at unravelling molecular mechanisms allied with this disorder and identifying genes and pathways that are altered causing PCOS as a pre-requisite need. Furthermore, this study intends at assessing the therapeutic potentials of Gymnemasylvestre phytocompounds mainly triterpene saponins against targeted proteins and helps in seeking exemplar drug candidates. The study is designed in 2 major parts—firstly identifying key proteins involved in pathophysiology by tracing back the deregulated genes in mRNA expression profiles of PCOS Patients obtained from GEO datasets database further compared and analysed by GEO2R Analyzer and significantly deregulated genes were subjected to PPI network, KEGG and GO analysis using STRING and ShinyGO tools. The second half of the study involved molecular docking its visualisation and in silico pharmacological analysis of imminent phytocompounds revealing plausible drug candidates.

Results

In the study, most implied deregulated genes were MRP gene family, ICT1, NDUFA12, VDAC3, APOO, TOMM5, COX6C, COX7B, EDN1 and EDN3 genes whose functional enrichment suggests flawed metabolism of proteins and damaged mitochondrial translation. With high binding affinity, less toxicity at higher dose level Lupeol, Beta-Amyrin, Beta-Elemene, Stigmasterol, Gymnestrogenin and Dammarane proves to be efficient drug candidates.

Conclusion

The findings of this study imply better understanding of the molecular mechanism of the disorder and encourage further clinical studies pertaining to medicinal natural phytocompounds of Gymnemasylvestre.
Is endoscopic septoplasty effective in all types of septal deviations? An observational study on subjective and objective assessment of nasal airway
Authors: Haque Misbahul , Kar Titas , Mukherjee Diptanshu
Published: August 2023

Background

Endoscopic septoplasty has become the preferred choice for septal surgeries for most surgeons due to its precise manipulation and reduced wear and tear. However, the improvement of the airway may vary depending upon the type of septal deviation the patient presents with. Cottle in 1946 stated that just mere dealing with deviated septum alone would not ensure a good functional outcome and he further emphasized on addressing portions of the nose obstructing nasal airflow during surgery. The purpose of our study is to subjectively and objectively assess the effectiveness and corrective extent of endoscopic septal correction in different types of septal deviations (Mladina classification) using NOSE scores and Peak Nasal Inspiratory Flowmetry (PNIF). A prospective cross-sectional study was conducted in 87 patients presented in our department from July 2021 to June 2022 for endoscopic septoplasty.

Results

Post-surgery 1-month follow-up (N1), the correction in terms of NOSE scores was highest in Mladina IV and least in Mladina I deviations, and at the end of 3 months (N2), the correction was best recorded in Mladina VI deviations while the least remained in Mladina I. Similarly, PNIF 1-month follow-up (P1) result had the best correction in the Mladina IV and V groups with the least in Mladina I. 3 months of follow-up (P2) ended up showing a maximum improvement in the Mladina VI group. Paired t test values for improvement of NOSE and PNIF scores were significant (p value < 0.001) between preoperative, 1-month, and 3-month follow-up values and also for repeated measure ANOVA.

Conclusion

Our study reveals that the corrective power of endoscopic septoplasty differs with respect to different types of septal deviation in terms of nasal airflow, both subjectively and objectively. Thus, proper counseling and preoperative assessment is essential for better postoperative outcome and compliance.
Changing Tides? Anticancer Biologic and Biosimilar Use in Medicare Part B, 2019-2021
Authors: McClean Alison R. , Wagner Anita K. , Lu Christine Y.
Published: August 2023

Anticancer biosimilar use is rising but significant potential savings remain unrealized @alison_mcclean @ChrisLuPhD
Electron irradiation: From test to material tailoring
Authors: Alessi A. , Cavani O. , Grasset R. , Drouhin H.-J. , Safarov V. I. , Konczykowski M.
Published: August 2023

In this article, we report some examples of how high-energy electron irradiation can be used as a tool for shaping material properties turning the generation of point-defects into an advantage beyond the presumed degradation of the properties. Such an approach is radically different from what often occurs when irradiation is used as a test for radiation hard materials or devices degradation in harsh environments. We illustrate the potential of this emerging technique by results obtained on two families of materials, namely semiconductors and superconductors.
Black Enlightenment
Authors: Parekh Surya
Published: August 2023

In Black Enlightenment Surya Parekh reimagines the Enlightenment from the position of the Black subject. Parekh examines the works of such Black writers as the free Jamaican Francis Williams (1697–1762), Afro-British thinker Ignatius Sancho (1729?–1780), and Afro-American poet Phillis Wheatley (1753?–1784), placing them alongside those of their white European contemporaries David Hume (1711-1776) and Immanuel Kant (1724-1804). By rethinking the Enlightenment and its canons, Parekh complicates common understandings of the Enlightenment wherein Black subjects could exist only in negation to white subjects. Black Enlightenment points to the anxiety of race in Hume, Kant, and others while showing the importance of Black Enlightenment thought. Parekh prompts us to consider the timeliness of reading Black Enlightenment authors who become “free” in a society hostile to that freedom.
Body Image, Maturation, and Psychological Functioning in College Cheerleaders: A Matter of Position?
Authors: Monsma Eva V. , Gay Jennifer L. , Torres-McGehee Toni M.
Published: August 2023

This study examined body image correlates of disordered eating and depression among cheerleaders. Female collegiate cheerleaders (N = 243) completed a battery of surveys, including current and ideal body image related to clothing (i.e., daily clothing, midriff, and full uniform) and meta-perceptions (i.e., perspectives of parents, friends, and coaches). For body image dissatisfaction, all ideal body images were significantly smaller than current body images. Flyers that were significantly shorter and lighter had a lower body mass index and were later maturing, and they reported less dissatisfaction related to daily clothing and from the perspective of parent and friend than bases and back spots. After controlling for body mass index (4%), stepwise regression analyses indicated midriff uniform dissatisfaction (32%), social physique anxiety (6%), and parent meta-perception discrepancy (2%), which predicted disordered eating risk, whereas depression risk was predicted by social physique anxiety (19.1%) and coach meta-perception discrepancy (5.6%). In conclusion, specific focal points for social agents and sport governing bodies are offered with the goal of enhancing recognition, opportunities, and resources for the future of cheerleading.
Desapropriação - Desistência
Authors: Ferreira Silva
Published: August 2023

Tribunal de Alçada de São Paulo
Da não-incidência do ICM na venda do gelo
Authors: Machado Hugo
Published: August 2023

1. Considerações iniciais. 2. Competência para tributar os minerais doPaís. 3. A fronteira do imposto único. 4. Da água para o gelo não hámodificação essencial. 5. Conclusões.
Funcionário público - Classificação de cargos - Tributação - Arrecadação - Fiscalização
Authors: Siqueira Darcy Duarte de
Published: August 2023

Departamento Administrativo do Serviço Público
Taxa de conservação de estradas - Requisitos
Authors: Peixoto Cunha
Published: August 2023

Supremo Tribunal Federal
Taxa de serviços de estradas municipais - Base de cálculo
Authors: Abreu Leitão de
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Vencimentos
Authors: Trigueiro Oswaldo
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Assistente jurídico - Proventos - Equiparação
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Aposentadoria - Transferência da União para o Estado da Guanabara
Authors: Alckmin Rodrigues
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Correção monetária
Authors: Falcão Djaci
Published: August 2023

Supremo Tribunal Federal
Imposto sobre circulação de mercadorias - Importação - Bens de capital
Authors: Flôres Thompson
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Admissão a título precário - Limite de idade
Authors: Abreu Leitão de
Published: August 2023

Supremo Tribunal Federal
Professor - Regime de tempo integral - Estatuto do magistério
Authors: Guerra Cordeiro
Published: August 2023

Supremo Tribunal Federal
Desembargador - Contagem de tempo de serviço - Advocacia
Authors: Trigueiro Oswaldo
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Regime jurídico - INPI - Classificação de cargos
Authors: Siqueira Darcy Duarte de
Published: August 2023

Departamento Administrativo do Serviço Público
Funcionário público - Aposentadoria - Classificação de cargos - Direito adquirido
Authors: Mayer Luiz Rafael
Published: August 2023

Presidência da República
Estrangeiro - Mulher brasileira - Restrições constitucionais
Authors: Mayer Luiz Rafael
Published: August 2023

Presidência da República
O Regime Jurídico Especial do Servidor Público
Authors: Rocha João Baptista de Oliveira
Published: August 2023

1. Colocação do problema. 2. Intenção do emendador de 1969. 3.Competência repartida. 4. Tendência trabalhista. 5. Estados e municípios. 6. Solução de síntese.
Imposto sobre circulação de mercadorias - Transferência de mercadorias - Frete e seguro
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Empreitada - Reajustamento de preço - Ato administrativo - Revogação
Authors: Falcone Hermano Américo
Published: August 2023

Ministério da Fazenda
Imposto - Majoração - Previsão orçamentária
Authors: Guerra Cordeiro
Published: August 2023

Supremo Tribunal Federal
Imposto sobre serviços - Empresa de publicidade
Authors: Guerra Cordeiro
Published: August 2023

Supremo Tribunal Federal
Imposto sobre transporte rodoviário - Fato gerador - Passageiro
Authors: Mesquita Neto Antonio Augusto de
Published: August 2023

Ministério da Fazenda
Controle da poluição hídrica no Brasil
Authors: Pompeu Cid Tomanik
Published: August 2023

1. Introdução. 2. Legislação aplicável. 3. Organização administrativa.4. Conclusões.
A fiscalização ou controle da administração pública. O controle financeiro da administração descentralizado
Authors: Barros Júnior Carlos S. de
Published: August 2023

1. Delimitação do tema. 2. O direito como principio de ordem.3. A fiscalização ou controle administrativo, o controle hierárquico.4. Noção e classificação das formas pelas quais se manifesta ocontrole administrativo. 5. Divisão segundo o fim a que o controlese propõe. 6. Divisão sob o aspecto do momento em que se realiza.7. Divisão sob o aspecto do órgão de que a fiscalização emana. 8.A fiscalização política. 9. Outras modalidades de fiscalização oucontrole. 10. A correição administrativa. 11. A fiscalização financeira,controles interno e externo. 12. O controle financeiro na administraçãodescentralizada. 13. Nas empresas públicas em sentido amplo e fundações oficiais. 14. Dificuldades da matéria; a dispersão da atividade administrativa. 15. Controle a que se sujeitam as entidades referidas no item 12,' o controle financeiro. 16. A matéria na Constituição Federal, o debate e conclusão alcançada. 17. A Lei nº 6.223, de 14.7.1975.18. Os controles a que estão sujeitas as empresas públicas, sociedades de economia mista e fundações oficiais. 19. Entendimento da Lei nº 6.223. 20. O controle financeiro das fundações a que alude o art. 8º dessa lei.
Professor - Gratificação - Limitação de proventos
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Demora do pagamento - Ato ilícito - Correção monetária
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Justiça do Trabalho - Composição dos tribunais - Competência - Recondução de juízes
Authors: Silva Carlos Medeiros
Published: August 2023

- A restrição da recondução, por mais de dois períodos, expressaquanto aos classistas e temporários que compõem o TribunalSuperior do Trabalho, não se aplica aos Tribunais Regionais da mesmajustiça.- A recondução, a sua conveniência, e oportunidade são prerrogativasdo Presidente da República.- Interpretação da Emenda Constitucional nlJ 7, de abril de 1977 (art. 141, § 1º).
Tributo - Coisa julgada
Authors: Alckmin Rodrigues
Published: August 2023

Supremo Tribunal Federal
Empresa pública - Repouso semanal remunerado - Horas extras
Authors: Mayer Luiz Rafael
Published: August 2023

Presidência da República
O princípio e os princípios da licitação
Authors: Silva Antonio Marcello da
Published: August 2023

1. Princípio da licitação: livre escolha e princípio da licitação; conceitode licitação. 2. Princípios da licitação: procedimento formal; publicidade; igualdade entre os licitantes; sigilo na apresentação das propostas; vinculação ao edital; julgamento objetivo; adjudicação compulsória ao vencedor.
Imposto de circulação de mercadorias - Isenção - Crédito fiscal
Authors: Peixoto Cunha
Published: August 2023

Supremo Tribunal Federal
Imóvel rural - Estrangeiro - Delegação de poderes
Authors: Ramalhete Clóvis
Published: August 2023

Presidência da República
Tributo - Responsabilidade solidária - Normas
Authors: Galvêas Ernane
Published: August 2023

Ministério da Fazenda
Lei inconstitucional - Veto - Rejeição
Authors: Alves Moreira
Published: August 2023

Supremto Tribunal Federal
Imposto de renda - Provisão - Férias
Authors: Pereira Afranio Carvalho
Published: August 2023

Ministério da Fazenda
Domínio da União - Aforamento - Ação declaratória
Authors: Falcone Hermano Américo
Published: August 2023

Procuradoria da Fazenda Nacional
Dever de licitar e direitos dos concorrentes
Authors: Mello Celso Antônio Bandeira de
Published: August 2023

1. A atividade administrativa e o dever de licitar. 2. Empresas governamentais e licitação. 3. Licitação e direitos do licitante. 4. Controleda proposta mais vantajosa. 5. Responsabilidade por contrato indevido.
Lei municipal - Inconstitucionalidade - Representação
Authors: Flôres Thompson
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Semoventes - Indenização
Authors: Silveira José Neri da
Published: August 2023

Tribunal Federal de Recursos
Empresa estatal - Aplicações financeiras - Controle
Authors: Macedo José Antônio Bandeira de
Published: August 2023

Tribunal de Contas da União
Isenção fiscal - Autarquia - INCRA
Authors: Ramalhete Clóvis
Published: August 2023

Presidência da República
Taxa - Preço público - Serviço de lixo
Authors: Alves Moreira
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Regime jurídico - Iniciativa de lei
Authors: Munoz Soares
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Acumulação - Remuneração
Authors: Patterson William
Published: August 2023

Tribunal Federal de Recursos
Funcionário público - Aposentadoria - Ex-combatente
Authors: Branco Francisco de Salles Mourão
Published: August 2023

Tribunal de Contas da União
Sociedade de economia mista - Aplicações financeiras - Open market
Authors: Pacini Mário
Published: August 2023

Tribunal de Contas da União
Sociedade de economia mista - Sociedade controlada - Natureza jurídica
Authors: Munoz Soares
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Serviço extraordinário - Vantagem
Authors: Brito Washington Bolivar de
Published: August 2023

Tribunal Federal de Recursos
Passado e futuro da súmula do STF
Authors: Leal Victor Nunes
Published: August 2023

1. A Súmula como método. 2. Estabilidade relativa da jurisprudência.3. Revisibilidade da Súmula. 4. Efeitos processuais da Súmula. 5. Idealdo meio-termo. 6. Modificar, e não interpretar a Súmula. 7. Origeme crescimento da Súmula. 8. Princípio da relevância às avessas. 9. Orecurso extraordinário, a relevância e a Súmula. 10. Representaçãointerpretativa. 11. Apelo ao Supremo Tribunal.
Funcionário público - Peculato - Estado de necessidade
Authors: Madeira Carlos
Published: August 2023

Tribunal Federal de Recursos
Taxa - Poder de polícia - Taxa de expediente
Authors: Neder Antonio
Published: August 2023

Supremo Tribunal Federal
Leis, Decretos-lei e Decretos (1981)
Authors: Desconhecido Autor
Published: August 2023

.
Funcionário público - Adicionais - Lei estadual
Authors: Mayer Rafael
Published: August 2023

Supremo Tribunal Federal
Contrato administrativo - Reajustamento de preço - Peculato
Authors: Ramalhete Clóvis
Published: August 2023

Supremo Tribunal Federal
Rola ONZ w budowaniu podstaw ładu międzynarodowego – żandarm czy platforma do wypracowywania wspólnych rozwiązań?
Authors: Polaczek-Bigaj Marta
Published: August 2023

Modern international organizations have a tradition of more than a century, but with the passage of time, their structure and the tasks and role they play have naturally changed. The United Nations is undoubtedly the structure with the widest geographic scope, as well as substantive area of activity, and is the foundation of global governance and shared values. With the rise of various threats arising from technological development, globalization, or ecological devastation, among others, expectations of the UN are therefore growing. Despite a very large array of specialized institutions, as well as the association of almost every country in the world, the United Nations often fails to become effective in its endeavors. The following text is an attempt to answer the question of whether the United Nations should remain just a platform for working out solutions together, or whether it should take on the role of a gendarme of world peace. It is a brief synthesis based on a historical outline and the various aspects of its functioning, and aimed at indicating the challenges facing the UN and expectations of the structure.
Acquisitions and Technology Value Revision
Authors: Cai Xiangshang , De Cesari Amedeo , Gao Ning , Peng Ni
Published: August 2023

Acquisition announcements coincide with upward value revisions for the target firms’ technology peers, which are not due to economic relations based on product market, supply chain, or geographical location. Such a phenomenon is robust across subsample periods, not specific to merger or technology waves, and not related to product-market structure and the unique innovation features of certain technology-intensive industries. Firms experience more dramatic value revisions when they have deeper technology overlaps with their targets, are more dependent on technology, or when a transaction features higher premium or greater technology overlap between the acquirer and target. Our mechanism analysis provides evidence that is primarily consistent with the acquisition-probability hypothesis whereby acquisition announcements elevate expected technology synergies and merger prospects for peers and partially in line with the enhanced-investment hypothesis that peers’ revaluations correlate with increased technology investments. We do not find any evidence in line with the competition-balance hypothesis that attributes peers’ value revisions to the change in industrial competition intensity. Overall, our results demonstrate that acquisition announcements disseminate novel information about the value of technology that is of common interest among firms with close technologies.

This paper was accepted by Gustavo Manso, finance.

Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4890 .
Managing Weather Risk with a Neural Network-Based Index Insurance
Authors: Chen Zhanhui , Lu Yang , Zhang Jinggong , Zhu Wenjun
Published: August 2023

Weather risk affects the economy, agricultural production in particular. Index insurance is a promising tool to hedge against weather risk, but current piecewise-linear index insurance contracts face large basis risk and low demand. We propose embedding a neural network-based optimization scheme into an expected utility maximization problem to design the index insurance contract. Neural networks capture a highly nonlinear relationship between the high-dimensional weather variables and production losses. We endogenously solve for the optimal insurance premium and demand. This approach reduces basis risk, lowers insurance premiums, and improves farmers’ utility.

This paper was accepted by Agostino Capponi, finance.

Funding: This work was supported by the Research Grants Council, University Grants Committee [Grants GRF 16502020, GRF 16504522, and T31-603/21-N], Singapore Ministry of Education Academic Research Fund Tier 1 [Grants RG143/19 and RG55/20], the Natural Sciences and Engineering Research Council of Canada [Grants RGPIN-2021-04144 and DGECR-2021-00330], the Research Database Matching Fund, and the School of Business and Management, Hong Kong University of Science and Technology.

Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2023.4902 .
A holistic approach to assessing an individual with urinary incontinence
Authors: Kelly Anne Marie
Published: August 2023

Urinary incontinence can have an overwhelmingly negative impact on an individual's quality of life. The personal, physical, psychosocial and sexual implications of urinary incontinence can affect health and well-being. This can increase the risk of falls, depression, anxiety, social isolation alongside a greater need for long-term care from a individual's own home. Statically, the prevalence rates of urinary incontinence increases with age; however, incontinence is not an inevitable or acceptable part of ageing—symptoms can be improved and managed effectively for suffers of this common condition.

Urinary incontinence can be challenging to assess, address and overcome for individuals. However health professionals need to have the expertise and experience to undertake a comprehensive continence assessment. When assessment is completed evidence-based interventions can be recommended, implemented and subsequently evaluated.
Zorunlu Örgün Öğretim Okullarında Eğitimsel Etkililik: Anne-Baba Görüşleri Temelinde Bağlamsal Model Arayışı
Authors: YILDIRIM Kamil
Published: August 2023

Öğrencilerin edinimi eğitimsel etkililik ölçütü olduğu gibi bağlamsal değişkenlerin etkilerinin azaltılması da eğitimsel etkililik ölçütüdür. Bu çalışmada, anne-babaların zorunlu örgün öğretim okullarında verilen eğitimin etkililiğine ilişkin algıları, bu algıları açıklayan bağlamsal değişkenleri içeren bir modelin ortaya konulması amaçlanmaktadır. Çalışma nicel verilere dayalı betimsel ve ilişkisel desende gerçekleştirilmiştir. Çalışma grubunu 2021 Eylül-Kasım döneminde Aksaray ilinde zorunlu örgün öğretim kademesinde öğrencisi olan anne-babalar oluşturmaktadır. Katılımcılara kolay ulaşılabilir ve kartopu örneklemeyle erişilmiştir. Araştırmacı tarafından geliştirilen veri toplama aracıyla toplam 296 anne-babaya ait veri incelenmiştir. Verilerin analizinde betimsel istatistiklerin yanı sıra açımlayıcı faktör analizi, kümeleme analizi, tek yönlü varyans analizi, X2 (Chi-Square) ve lojistik regresyon analizleri gerçekleştirilmiştir. Çalışmada okuldaki eğitimin kısmi düzeyde etkili olduğu belirlenmiştir. Anne-baba eğitimsel etkililik algısı ile okul türü, okul kademesi, yerleşim yeri ve aile büyüklüğünün anlamlı ilişkisi bulunmuştur. Model denemeleri okulun türü, okul kademesi ve ailenin büyüklüğünü içeren bir model üretmiştir. Kalabalık ailelere göre küçük aileler okuldaki eğitimin etkisiz olduğunu algılamaktadır. Ebeveynler, özel okula göre devlet okullarındaki eğitimin ve meslek liselerindeki eğitimin etkisiz olduğunu algılamaktadır.