bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Kandungan Amilosa dan Antioksidan dari Tepung Pisang Goroho (Musa acuminafe, sp)
Authors: Sakti Dwi , Suryanto Edi , Assa Jan Rudolf
Published: January 2025

Abstract
Goroho banana (Musa acuminafe, sp) is a local banana variety native to North Sulawesi. Flour made from goroho bananas has a high nutritional content, consisting of 75.18% carbohydrates, 5.16% protein, and 0.97% fat. Its starch content reaches 70.78%, with 39.59% amylose and 31.19% amylopectin. This study aims to examine the amylose content and antioxidant activity in goroho banana flour. The research stages include material preparation, amylose content analysis, phytochemical component extraction, and testing of total phenolic content, tannin content, and antioxidant activity using DPPH, ABTS, and FRAP methods. Data analysis was performed using SPSS software. The results showed that the highest amylose content was found in sample P3, amounting to 15.19±0.28 µg/mL. The highest total phenolic content was found in sample P2, with a value of 25.41±2.31 µg/mL, while the highest total tannin content was observed in sample P4, amounting to 54.78±0.33 µg/mL. The highest antioxidant activity, based on DPPH, ABTS, and FRAP methods, was found in sample P2, with respective values of 81.15±0.14%, 99.04±0.27%, and 146.39±2.01 mmol/100 g. These findings indicate that goroho banana flour contains significant bioactive compounds and has potential as a natural source of antioxidants.
Abstrak
Pisang goroho (Musa acuminata, sp.) merupakan salah satu varietas pisang lokal khas Sulawesi Utara. Tepung dari pisang goroho memiliki kandungan gizi yang cukup tinggi, terdiri dari karbohidrat sebesar 75,18%, protein 5,16%, dan lemak 0,97%. Kandungan patinya mencapai 70,78%, dengan komposisi amilosa sebesar 39,59% dan amilopektin 31,19%. Penelitian ini bertujuan untuk mengkaji kandungan amilosa dan aktivitas antioksidan dalam tepung pisang goroho. Tahapan penelitian meliputi persiapan bahan, analisis kandungan amilosa, ekstraksi komponen fitokimia, serta pengujian kandungan total fenolik, tanin, dan aktivitas antioksidan menggunakan metode DPPH, ABTS, dan FRAP. Analisis data dilakukan menggunakan software SPSS. Hasil penelitian menunjukkan bahwa kandungan amilosa tertinggi terdapat pada sampel P3 sebesar 15,19±0,28 µg/mL. Kandungan total fenolik tertinggi ditemukan pada sampel P2 dengan nilai 25,41±2,31 µg/mL, sedangkan kandungan total tanin tertinggi terdapat pada sampel P4 sebesar 54,78±0,33 µg/mL. Aktivitas antioksidan tertinggi berdasarkan metode DPPH, ABTS, dan FRAP secara berurutan ditemukan pada sampel P2, dengan nilai masing-masing sebesar 81,15±0,14%, 99,04±0,27%, dan 146,39±2,01 mmol/100 g. Hasil ini menunjukkan bahwa tepung pisang goroho memiliki kandungan senyawa bioaktif yang signifikan dan potensi sebagai sumber antioksidan alami.
A rede urbana atlântica colonial do Baixo Sul baiano e as marcas da agência indígena
Authors: Dias Marcelo
Published: January 2025

Trata-se de uma investigação sobre a formação da rede urbana colonial do Baixo Sul baiano (Bahia, Brasil) entre os séculos XVI e XIX. Naqueles territórios, as experiências de catequese e aldeamento dos jesuítas se iniciaram ainda no século XVI, sendo que as primeiras povoações portuguesas surgiram no arquipélago de Cairu, Tinharé e Boipeba no início do século XVII, seguida da formação de outros núcleos no continente que posteriormente evoluiriam para a condição de freguesias, povoações e vilas. O processo de urbanização contou, para além dos portugueses, com o protagonismo de outros agentes, cujas marcas, apesar de invisibilizadas na memória regional e na historiografia, ficaram gravadas na toponímia, na urdidura da rede e na tessitura dos núcleos urbanos. O intento desse artigo é justamente repensar aquele processo de urbanização, buscando fazer emergir as ações daqueles protagonistas invisibilizados, sobretudo dos povos originários. Através de fontes textuais produzidas por autoridades coloniais e religiosos e um conjunto cartográfico daquele período, busca-se identificar traços da paisagem que manifestam os interesses e os sentidos das intervenções dos diferentes grupos humanos no ambiente físico.
Poder, conhecimento e visualidade na governação de José Custódio de Sá e Faria no Rio Grande de São Pedro (c. 1764 – c. 1769)
Authors: Pereira Gama Mariana
Published: January 2025

Este trabalho tem como objetivo analisar a articulação entre as demandas governativas e as atribuições técnicas exercidas por José Custódio de Sá e Faria durante seu período enquanto governador da capitania fronteiriça e subalterna do Rio Grande de São Pedro. Busca-se compreender o lugar da produção de conhecimento, especialmente o cartográfico, no processo de implementação de uma “cultura visual institucional” enquanto projeto político e comunicacional, inserido em um plano maior de avanço do aparato institucional e expansão fronteiriça da América Portuguesa meridional. Para isso, a pesquisa se fundamenta no estudo da correspondência entre as autoridades das capitanias do Rio Grande de São Pedro e de São Paulo, bem como na análise da produção cartográfica referente ao Rio Grande. Verifica-se que o governador subalterno desempenhou o papel de vetor na produção e transmissão de saberes entre o território fronteiriço e as capitanias do sudeste.
“Recôncavos da Bahia no plural”: Mercado interno, cartografia e integração territorial entre a Comarca de Ilhéus e a Baía de todos os Santos (séculos XVII e XVIII)
Authors: Fonseca Borsoi Diogo
Published: January 2025

Este artigo visa abordar a integração territorial da Capitania/Comarca de Ilhéus à Baía de Todos os Santos entre os séculos XVII e XVIII. Correntes historiográficas mais tradicionais construíram interpretações sobre a história da Capitania/Comarca pautadas nos conceitos de decadência econômica e de esvaziamento demográfico. Recentemente, estudos têm relativizado esses conceitos, indicando uma produção de farinha e madeira voltada ao mercado interno de abastecimento, principalmente, para as vilas da Baía de Todos os Santos. Em decorrência disso, alguns registros cartográficos do período figuravam essas áreas como uma unidade territorial.
Atuação e Desafios do Profissional Biomédico na Indústria Farmacêutica como Medical Science Liaison (MSL)
Authors: Grossi Carolinne de Campos , Di Lallo Vieira Ana Julia
Published: January 2025

Para estar-se apto ao cargo de Medical Science Liaison (MSL) nas indústrias farmacêuticas, é necessário que o profissional tenha formação científica e prévia experiência atuando no ramo médico e farmacêutico. O cargo de MSL foi ocupado pela primeira vez na Upjohn Company em 1967, com a necessidade de um profissional com maior aprofundamento sobre temas relacionados à pesquisa e à ciência, e portanto, o pré requisito para candidatarse a esta vaga no passado era ter formação superior completa no curso de Medicina.1-5 Com o tempo, o perfil e as qualificações dos MSL´s no Brasil mudaram, este estudo tem como objetivo identificar a atuação e desafios do profissional biomédico na indústria farmacêutica atuando na profissão de Medical Science Liaison (MSL). Especificamente, buscam-se analisar quais são os perfis dos atuais profissionais MSL´s no mercado de trabalho das diversas indústrias farmacêuticas, nacionais e multinacionais. Para isto, foi realizado uma pesquisa de campo com profissionais convidados que atuam nesta profissão, os dados deste estudo foram coletados por meio do questionário aberto no dia 15/12/2022 com fechamento na data de 15/02/2023. A pesquisa obteve 32 respostas, posteriormente, foram sintetizados gráficos que apontam diversas oportunidades do biomédico em exercer a função de MSL (Medical Science Liaison), e também enfatiza o novo cenário brasileiro em 2023 com menos médicos atuando neste segmento (apenas 3,1% dos respondentes).
VIOLÊNCIA OBSTÉTRICA NA ASSISTÊNCIA AO PARTO E NASCIMENTO EM UM MUNICÍPIO DO NORDESTE BRASILEIRO
Authors: Loiola Maria Gabriela Oliveira , Lemos de Beltrão Izabel Cristina Santiago , Leandro Maria Letícia de Moura , Souza Carla Andréa Silva , Luanna Gomes da Silva  , Albuquerque Grayce Alencar , Gomes Emiliana Bezerra , Cruz Rachel de Sá Barreto Luna Callou , Dayanne Rakelly de Oliveira
Published: January 2025

Objetivo: analisar a ocorrência e fatores envolvidos na violência obstétrica durante a assistência ao parto e nascimento em uma maternidade pública do nordeste brasileiro. Métodos: Trata-se de um estudo descritivo-exploratório, com abordagem quantitativa, realizado em uma maternidade municipal localizada no nordeste do Brasil, estado do Ceará. A amostra contou com 142 mulheres em puerpério imediato de parto normal ou cesariana. Utilizou-se um formulário próprio para coleta de dados. Para análise realizou-se por meio de teste estatístico. Resultados: As boas práticas prevaleceram em relação à ocorrência de violência obstétrica na assistência ao parto. As variáveis “escolaridade” e “estado civil” mostraram associação estatisticamente significante com violência obstétrica (p<0,05). Conclusão: Diante disso, os fatores sociodemográficos contribuem para os casos de violência obstétrica. Assim, torna-se importante o desenvolvimento de ações, com intuito de perpetuar condutas eficazes no contexto da assistência obstétrica.
ÉTICA E GESTÃO NA SAÚDE PÚBLICA, UMA ANÁLISE CRÍTICA
Authors: Enoque Fernandes de Araújo  , Cristiane dos Santos Paulino  , Pedro Fernandes de Araújo  , Margarida Fernandes de Araújo  , Wanderley Fernandes de Araújo  , Antonio Carlos Pereira
Published: January 2025

A Gestão Pública em Saúde emerge como uma ação política terminante para garantir a qualidade dos serviços e a eficiente alocação de recursos. Nesse sentido, a gestão em saúde não apenas organiza e administra os sistemas de saúde, mas também reflete valores éticos e morais que buscam o bem-estar coletivo e a justiça social, constituindo-se como uma expressão concreta da responsabilidade política para com a sociedade. No cenário da área da Saúde Pública, a ética surge como um pilar fundamental, para contribuir com a gestão em saúde que não atenda apenas às demandas individuais, mas, sobretudo, beneficie o coletivo, traçando um caminho mais humanizado e equitativo dentro da perspectiva da Saúde Coletiva.
BARREIRAS LIMITANTES E FACILITADORES PARA O RASTREAMENTO DO CÂNCER DE MAMA: REVISÃO INTEGRATIVA
Authors: Layanne Cavalcante de Moura  , Júnior Luiz Ayrton Santos
Published: January 2025

Objetivo: Analisar na literatura as evidências científicas sobre as barreiras limitantes e facilitadoras para o rastreamento do Câncer de Mama. Método: Revisão integrativa da literatura realizada através da Biblioteca Virtual em Saúde e U. S. National Library of Medicine. Resultados: Foram selecionados 18 artigos para essa revisão. As evidenciam apontam que é necessário identificar a população-alvo para a definição das ferramentas de diagnóstico, o delineamento das abordagens programáticas e a elaboração do processo de implantação e ampliação do rastreamento do câncer mamário. Diante dos diversos fatores que dificultam a acessibilidade e realização do rastreio, é indispensável a elaboração de estratégias e fortalecimentos que superem essas barreiras. Conclusão: Diante das barreiras e facilitadores para o rastreamento do câncer de mama, espera-se que os achados possam auxiliar em questões críticas a serem investigadas com profundidade sobre as melhores estratégias para o rastreamento do CM, contribuindo para a elaboração de políticas de rastreamento.
CONHECIMENTO DE ADOLESCENTES SOBRE A DOAÇÃO DE SANGUE
Authors: Nogueira Gabriel David , Rodrigues Aline Aparecida , Ribeiro Cássio Soares , Daniel Ferreira de Oliveira  , Elias Marcelino da Rocha  , Ferreira Ellen Gabriela Gomes
Published: January 2025

Objetivou-se conhecer e avaliar o perfil de adolescentes do ensino médio sobre a doação sangue. Trata-se de um estudo transversal, com abordagem quantitativa, realizado em uma instituição de educação pública localizada em município no interior de Mato Grosso, na Amazônia Brasileira. Participaram da pesquisa 114 adolescentes com idade entre 15 e 19 anos. A coleta aconteceu em 2023 por meio de um questionário. A análise estatística foi feita no programa EpiInfo. A maioria dos adolescentes era do sexo feminino (57,9%); a prevalência de idade foi de 17 anos; sendo que somente 8 desses já fizeram a doação de sangue. O principal motivo citado para a falta de interesse pela doação foi a escassez de incentivo (69%), medo de passar mal durante a doação, além dos mitos e tabus perpetrado culturalmente. Em relação ao conhecimento, de forma geral, os resultados mostraram lacunas entre os adolescentes sob vários aspectos relacionados ao processo de doação de sangue, sendo a falta apoio dos responsáveis legais, estilo de vida estressante, correria do dia a dia, divergência de interesse entre os pais e os adolescentes. Percebe-se a necessidade de trazer a abordagem dessa temática para as instituições de ensino, a fim de instigar a solidariedade sobre o assunto.
FORÇA ISOMÉTRICA CORRELACIONA-SE COM DESEMPENHO EM TESTES FUNCIONAIS EM IDOSOS
Authors: Filho José Morais Souto , Daiane Nonato de Lima  , Almeida Alexandra Tomaz de Sousa , Rabêlo Lívya Soares , Marcos Antonio Medeiros do Nascimento  , Maia Divanalmi Ferreira , Alvaro Luis Pessoa de Farias  , Leano Emmanuel José Marques
Published: January 2025

Introdução: O envelhecimento acarreta mudanças fisiológicas significativas, incluindo o declínio da força e da resistência muscular, impactando a qualidade de vida do idoso Objetivo: Classificar idosos com diferentes níveis de força e comparar o desempenho deles em testes funcionais que expressam a capacidade de realizar atividade da vida diária. Metodologia: O estudo, envolveu 36 idosas com idade entre 60 a 84 anos. Foram realizados testes de preensão manual, flexão de cotovelo em 30 segundos, levantar e sentar da cadeira em 30 segundos e Time Up Go. As análises estatísticas incluíram testes de Shapiro-Wilk, Mann-Whitney, correlação de Pearson e d de Cohen, com nível de significância de 5%. Resultados: As voluntárias foram separadas em grupos por nível de força. Baixa força (BF) 11,94 quilograma força (kgf) e média força (MF) 19,00 kgf. Houve diferença estatística significante na flexão de cotovelo (P=0,015; d=0,867) entre os grupos. Foi encontrada uma correlação moderada e positiva (r=0,408; P=0,015; d=0,166) entre níveis de força e flexão de cotovelo. Uma fraca correlação negativa (r=-0,384; P=0,023; 0,147) foi observada entre Time Up Go e levantar e sentar. Conclusão: O Idosos do presente estudo, com diferentes níveis de força isométrica mostraram distinção nos resultados em testes funcionais, comprometendo a autonomia física e a qualidade de vida.
ИССЛЕДОВАНИЕ ПРАКТИЧЕСКОЙ ФУНКЦИИ ЮРИСПРУДЕНЦИИ
Authors: Абубакарова М.М.
Published: January 2025

Юриспруденция – это теоретическое право, и ее практическое применение отличается от других правовых форм. С введением концепции управления страной в соответствии с законом исследования ведомственной юриспруденции постепенно привлекли внимание экспертов отрасли, а практические функции традиционной юриспруденции постепенно игнорировались. Однако это не означает, что социальный статус юриспруденции в результате снижается. Взяв прямую практику и косвенную практику юриспруденции в качестве объекта исследования, данная статья кратко описывает функцию прямой практики и функцию косвенной практики юриспруденции и подтверждает, что функция косвенной практики является необходимой теоретической поддержкой юриспруденции для обеспечения правосудия.
ТРУДНОСТИ УВЕДОМЛЕНИЯ УЧАСТНИКОВ
ГРАЖДАНСКОГО СУДОПРОИЗВОДСТВА
Authors: Хабиева З.Д.
Published: January 2025

Статья посвящена вопросам надлежащего уведомления сторон в гражданском судопроизводстве в России. Подчеркивается важность своевременного и точного уведомления для справедливого разрешения дел. Обсуждаются основные методы уведомления, включая заказные письма, СМС и доставку через курьера, с акцентом на такие сложности, как уклонение ответчика и задержки. Предлагается пилотное внедрение службы судебных курьеров в отдельных регионах для повышения эффективности уведомления и сокращения задержек в судебных процессах.
НОТАРИАЛЬНЫЕ ДЕЙСТВИЯ КАК СРЕДСТВО ОБЕСПЕЧЕНИЯ И ЗАЩИТЫ ПРАВ И ЗАКОННЫХ ИНТЕРЕСОВ ГРАЖДАН
Authors: Магомадова Э.И.
Published: January 2025

Данный доклад раскрывает некоторые актуальные нотариальные действия, направленные на обеспечение защиты прав и законных интересов граждан и юридических лиц. В частности, были раскрыты нотариальные действия в отношении сделок с недвижимостью, порядок ведения реестра. Также было упомянуто наступление ответственности за совершение нотариальных действий, нарушающих права и законные интересы граждан и юридических лиц.
ACADEMIC RESILIENCE IN LEARNING MATHEMATICS: A MIXED METHOD
Authors: Judelyn L. Hernane  , Linagyn Gementiza-Cubio
Published: January 2025

The study aimed to describe the lived experiences of mathematics teacher education students in a local college regarding their academic resilience in learning mathematics. This study engaged a mixed-method design, utilizing a parallel convergent approach. The participants of the study were the mathematics teacher education students from all levels. There were 150 students who were randomly selected for quantitative and 14 for the qualitative, 14 for in-depth interview which were purposively selected. Based on the results of the study, the overall level of academic resilience in learning mathematics was determined as very high. The results from the quantitative and qualitative converged when they were being corroborated. The value indicator, rated very high, aligns with the theme of cultivating a positive attitude toward mathematics, emphasizing its importance in achieving academic goals and solving real-life problems. The struggle indicator, rated high, reflects the theme of difficulties with the basics of mathematics, highlighting challenges with analyzing and understanding word problems. Lastly, the growth indicator, rated high, corresponds with the theme of developing intrinsic motivation, underscoring the belief that everyone has the potential to succeed in mathematics. This suggests that schools may implement essential courses that applicable across various subjects. By providing regular study skills workshops, practice tests, and access to tutoring services, students will be better prepared for mathematics assessments, increasing their resiliency.
KEYWORDS: Academic resilience, mixed methods, teacher education students, Philippines
REIMAGINING DEMOCRACY AND ECONOMY: THE VISION OF DR. B.R. AMBEDKAR
Authors: Hareet Kumar Meena  , Sangeeta Dhayal
Published: January 2025

Dr Bhimrao Ambedkar, a visionary leader and social reformer, was a staunch advocate of democracy and economic equality. This research paper examines the democratic framework of Dr Ambedkar, with a particular focus on its economic structure and underlying principles. It explores how the political ideology of Ambedkar was shaped by his commitment to social justice, equality, and economic freedom. The study delves into his belief that political democracy is incomplete without economic democracy and highlights his emphasis on equal opportunities, fair resource distribution, and the eradication of caste-based discrimination. The paper also analyses Ambedkar’s critique of hereditary systems, the role of functional opposition in parliamentary democracy, and the significance of free and fair elections in ensuring transparency and accountability. By contextualising the vision of Ambedkar within the broader framework of democratic governance, this research underscores the relevance of his vision in addressing contemporary issues of inequality, social exclusion, and economic injustice.
KEYWORDS: Dr. B. R. Ambedkar; Democratic Framework; Economic Structure; Parliamentary Democracy; Social Justice; Caste and Discrimination; Inclusive Governance.
FEEDING CORN EXTRACT INFLUENCE ON THE INTERNAL ORGANS OF MEAT CHICKENS DEVELOPMENT
Authors: Osepchuk Denis , Svistunov Andrey , Agarkova Natal'ya , Astahova Dar'ya , Smolin Sergey
Published: January 2025

The purpose of research is to study the effect of feeding complete feed (CF) with 6.5 % corn extract and 6.2 % mixture of corn extract and perlite on productivity, ration conversion and development of internal organs of broiler chickens. From the fourth day of cultivation, three groups of 38 heads of young birds were formed according to the principle of pair-analogues. In accordance with the scheme of the experiment, the birds from the 1st (control) group were given complete feed (CF) without the inclusion of additives. Corn extract (CE) was added to the complete mixed feed for poultry of the 2nd (experimental) group in the amount of 6.5 % by weight of the feed. The diet for chickens of the 3rd group included 6.2 % of a mixture of corn extract and perlite (in a ratio of 3.42 : 1). Feeding 6.5 % corn extract resulted in a 1.8 % increase in heart mass; a significant decrease in liver weight by 12.7 % (p < 0.05), in contrast to the group of birds that received complete feed without additives. Also, when feeding a mixture of 6.2 % corn extract and perlite, there was a trend towards an increase in heart weight by 2.5 % and a decrease in liver weight by 15.3 % (p < 0.05), relative to the control group. The pH values of the blind processes were in the range of 6.23–6.30, which is the biological norm. The inclusion of 6.5 % corn extract and a mixture of 6.2 % corn extract and perlite in a ratio of 3.42 : 1 by weight of the feed into complete mixed feeds can help increase the growth intensity of meat poultry, while not adversely affecting the growth and development of internal organs.
Bazı Zeytin Çeşitlerinde Biyogübre Uygulamalarının Çelik Köklenmesine Etkileri
Authors: Dölek Cansu
Published: January 2025

Çalışmada bitkisel materyal olarak Domat, Gemlik ve Sarı Ulak zeytin çeşitleri kullanılmıştır. Çelikler 20 cm uzunluğunda yarı odun çelikleri olarak hazırlanmıştır. Uygulama, köklendirme ortamı olarak perlit ve torf kullanılarak yürütülmüştür. Çalışmada hümik asit, deniz yosunu ve biotarm uygulamaları ile sürgün oluşturma ve köklenme durumları takip edilmiştir. Uygulamada kullanılan Hümik asit, deniz yosunu ve Biotarm hem çeliklerin dikimi sırasında hem de köklenme tamamlanana kadar sulama suyuna eklenerek bitkilere verilmiştir. Çeliklerin sürgün uzunluğu, sürgündeki yaprak sayısı, köklenme yüzdesi, sürgün verme yüzdesi, kök sayısı ve kök uzunluğu kaydedilmiştir.
İlk sürgün oluşumları Biotarm uygulaması yapılmış çeliklerde gerçekleşmiştir. Ortalama köklenme yüzdesi, kök uzunluğu ve sayısı en yüksek Biotarm uygulaması yapılmış çeliklerde bulunurken, Hümik asit ve deniz yosunu bunu takip eden uygulamalar olmuştur. Çeşitlere ait uygulamalar arasında en düşük değerler veren grup Kontrol grubu olmuştur.
Nutritional, Textural, Color and Sensory Characteristics of Chips with Hazelnut Flour and Skin: Effects of Baking Conditions and Substitution Levels
Authors: Mazı Bekir Gökcen
Published: January 2025

This study aimed to improve wheat chips' nutritional value by incorporating hazelnut flour and hazelnut skin. Chips were produced with wheat flour (control) and with partial substitution of wheat flour by hazelnut flour (HF) or hazelnut flour plus hazelnut skin (HFS) at 20, 30, and 40% concentrations, then baked at 180, 200, and 220 °C for various durations. The effects of HF/HFS addition on raw dough's physicochemical properties, as well as chips' moisture content, weight loss, color, texture, and sensory attributes, was studied. Adding HF/HFS increased protein, fat, ash, and mineral contents. Baking conditions and substitution levels significantly affected chips quality. Inclusion of HF/HFS resulted in higher weight loss during baking, a darker, more reddish-brown appearance, and lower fracture force and deformation at fracture values corresponding to a softer and more brittle structure. Significant correlations among instrumental and sensory properties were identified via Pearson's correlation and principal component analysis.
The Effect of Different Varieties and Planting Times on the Yield and Quality of Calendula (Calendula officinalis L.) Flowers and Seeds in Çukurova Conditions
Authors: Gedik Keleş Selin
Published: January 2025

This study was carried out to determine the effects of different varieties (Pot Marigold and Orange King) and planting times (March 15, April 1 and April 15) on the yield and quality of flowers and seeds of Calendula (Calen-dula officinalis) plant in the 2020-2021 growing seasons in Çukurova conditions. The experiment was set up in a split plot randomized complete block design with 3 replications. According to the data, the highest dry flower yield (360.63 kg/ha, March 15, 2021) was obtained from Pot Marigold variety, the highest fresh flower yield (1308.67 kg/da, March 15, 2020), flower essential oil (0.05 %, 15 March 2021) was obtained from Orange King variety. Highest seed yield 35.6 kg/da from balloon smooth shaped, highest seed fixed oil 15.39 % from balloon smooth shaped, was obtained. The maincomponent in flower essential oil was α-cadinol and in seed oil it as identified as calendic acid (α+β). Both varieties exhibit similar trends in terms of essential oils for use in commercial medicinal and food industries, while the Pot Marigold variety stands out in terms of dry flower yield, seed yield, and seed oil.
Estimating Daily Streamflow Values Using Artificial Neural Networks, Support Vector Regression and Multiple Linear Regression Models for Ceyhan River Basin
Authors: İrvem Ahmet
Published: January 2025

Streamflow data are very important for effective planning and management of water resources in basins. In this study, Artificial Neural Networks (ANN), Support Vector Regression (SVR) and Multiple Linear Regression (MLR) models were developed to estimate the daily streamflow of three different rivers in the Ceyhan River Basin. Daily precipitation and temperature data obtained from The Modern-Era Retrospective Analysis for Research and Applications, Version 2 (MERRA-2) re-analysis data were used as predictor variables in the models. The estimation performances of the models were evaluated with different statistical performance measures. According to the evaluation results, the SVR model demonstrated the best performance in daily streamflow estimation for the Ceyhan River, achieving R² = 0.95 and RMSE = 28.20 m³ s-1. Additionally, for Söğütlü Creek, the results were R² = 0.82 and RMSE = 6.57 m³ s-1, while for Keşiş Creek, R² = 0.93 and RMSE = 1.45 m³ s-1 were obtained. The findings indicate that the SVR model predicts daily streamflow more successfully than the other models. Furthermore, it was found that the performance of the models developed using machine learning algorithms was superior to that of the linear regression model.
Asma Anaç ve Çeşitlerinden İzole Edilen Endofitik Fungusların Asma Gövde Hastalıklarıyla İlişkili Bazı Fungal Patojenlere Karşı In Vitro Antagonistik Etkileri
Authors: Yağcı Arife
Published: January 2025

Bu çalışma, asma gövde hastalıkları ile ilişkili patojen funguslara karşı endofitik fungusların (Tokat koşullarında yetiştirilen asma çeşit ve anaçlarından elde edilen) in vitro antagonistik etkilerini belirlemek amacıyla gerçekleştirilmiştir. Antagonistik etkilerin ortaya çıkarılmasında PDA (patates dekstroz agar) besi yerinde ikili kültür metodu takip edilmiş, izolatlar arasındaki engelleme mesafeleri ölçülmüştür. Fungal izolatların patojenisitesi Narince üzüm çeşidinin dormant kalemleri üzerinde test edilmiş, izolatlar tepeden inokulasyon yöntemine göre uygulanmıştır. İnokule edilmiş kalemler 1 litrelik saksılara dikilmiş, 25°C sıcaklık ve %85 nispi nemde 3 ay süreyle büyütülmüştür. Endofitik funguslarla Botryosphaeria dothidea arasında 0-13.3 mm; Cadophora lutea-olivacea arasında 0-6.3 mm; Cytospora salicacearum arasında 0-0.7; Diatrype stigma ile 0-5.0 mm; Truncatella angustata arasında 0-8.7 mm’lik engelleme mesafesi meydana gelmiştir. Hiçbir endofit patojenlerin tamamını aynı ölçüde engelleyememiş, bazı patojenlere karşı güçlü bazılarına da zayıf derecede etki ortaya çıkmıştır. Tüm endofitlerin inhibisyon performansı birbiriyle kıyaslandığında Fusarium avenaceum’un en etkili, Penicillium commune ise tamamen etkisiz olduğu bulunmuştur. Patojenisite testlerinde endofitik türler kayda değer bir nekroz yaratmazken, B. dothidea, C. lutea-olivacea, C. salicacearum, D. stigma ve T. angustata 23.6-65.0 mm’lik nekozlar meydana getirmiştir. Bu çalışma asmadaki farklı endofitlerin, asma gövde hastalıklarıyla ilişkili farklı patojenlerin biyolojik mücadelesi için ümitvar olabileceğine işaret etmektedir.
The Impact of Post-Harvest Removal of Vegetative Residues on the Adult Population Density of the Tomato Leaf Miner, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae), in the Tomato-Growing Areas of Muğla
Authors: Türkmen Yaşar Mutlu
Published: January 2025

This study investigated the effects of tomato plant residues that remained in the field after harvest on the population growth of adult Tuta absoluta in open-field tomato growing areas of Muğla province. The research was conducted in Çamköy (Milas, Muğla) and Kızlan (Datça, Muğla) between 2015 and 2017 in a total of four fields, including one field with field cleaning and tillage after harvest and one field without field cleaning and tillage in each location. Pheromone traps were used to determine the development of adult T. absoluta populations. During the studies, a total of 3.670 and 5.423 T. absoluta adults were captured in Çamköy in the fields with and without field cleaning and tillage, respectively. Based on these findings, the total mean number of T. absoluta adults was found to be 159.57 and 235.78, respectively. The difference between the two means was determined to be statistically significant. In Kızlan, another region where sampling was conducted, a total of 3.127 and 5.440 T. absoluta adults were captured in fields that underwent post-harvest field cleaning and tilling, respectively. The mean number of adults in these fields was 142.14 and 247.27, respectively, showing a statistically significant difference between the two means. These results indicate that cultural treatments aimed at reducing T. absoluta populations in post-harvest production areas were effective in decreasing pest population density in the following season.
ASSESSING THE COHERENCE OF PRUDENTIAL REGULATION WITH MONETARY POLICY
Authors:   Financial University under the Government of Russia, Kulikov Mikhail V.
Published: January 2025

In the article, the author examines foreign experience in ensuring financial stability by implementing monetary and prudential methods. The author has developed an integral indicator for assessing the coherence of monetary policy with prudential regulation, and has also calculated the corresponding integral indicator for 15 countries with developed and developing financial markets.
ANALYSIS OF THE EFFECTIVENESS OF THE INTERNAL FINANCIAL AUDIT SYSTEM: MATURITY MODELS
Authors:   State Institute of Economics, Finance, Law and Technology, Bychkova Svetlana M. , Vasilyeva Ekaterina A. ,   State Institute of Economics, Finance, Law and Technology, Lebedeva Alina S. ,   State Institute of Economics, Finance, Law and Technology, Sekaeva Ekaterina V. ,   State Institute of Economics, Finance, Law and Technology
Published: January 2025

The article analyzes the evaluation of the effectiveness of the internal financial audit system using maturity models such as COSCO, COBIT, CMMI, and IIA. The key principles of each model, their advantages and disadvantages from the point of view of risk management and control are considered. The main purpose of the study is to develop criteria for creating a new maturity model that best meets the needs of organizations in matters of control and risk management, taking into account industry specifics and the growing level of digitalization in internal processes.
CURRENT ISSUES OF ACCOUNTING FOR CORPORATE INCOME TAX
Authors:   North Ossetian state University named after K. L. Khetagurov, Dzobelova V. B.
Published: January 2025

Profit is a key economic indicator that reflects the successful financial results of the enterprise. The article describes the principles of profit management of the organization. It presents how profit is formed from core activities and non-operating and financial activities. At the first stage, the laws regulating accounting and tax accounting, income tax were considered. An analysis of the structure of income received and expenses incurred was carried out. At the next stage, the procedure for establishing taxes and profits, in particular, was considered. We considered the Regulation on accounting “Accounting for settlements on income tax” PBU 18/02 and innovations in income tax in 2025.
Cost/benefit Analysis of Adding a Pre-treatment Step in the Lithium Ion Battery Recycling Process
Authors: - Zaid Thanawala
Published: January 2025

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Embedded systems Evolution and Trends in Avionics
Authors: - Arjun   Agaram  Mangad
Published: January 2025

Embedded systems usage has evolved with technology trends like semiconductors, power efficiency and miniaturization. Design focus on embedded systems has made it possible to be flexible and software-defined rather than focusing on a particular application and purpose. This has led to adoption across multiple industries. Operating systems, safety, and automation evolution have also made it feasible to be used in multiple applications and fields. Embedded systems have played a crucial part in the evolution of many different industries. One such industry where it has played a crucial part is the aviation industry. From safety to passenger experience, embedded systems play an important part in everything. This paper summarizes how changing trends and evolution in embedded systems have enabled the aviation industry to evolve. The paper also looks at new embedded systems trends and how they can be crucial in the aviation industry. We also look at challenges in bringing these technologies and trends to the aviation industry. The goal is to summarize all these trends and challenges here to add to the existing knowledge base of embedded system trends in avionics and look at the past evolution as a base to propel toward newer technologies and overcome any challenges we face from it.
Study of Exopolysaccharide Production by Lactic Acid Bacteria used in the Baking Industry and Comparison of Methods for Their Determination
Authors: Martirosyan Vladimir V. , Kostyuchenko Marina N. , Reynov Mikhail V. , Tyurina Olga E. , Savkina Olesia A.
Published: January 2025

Introduction: Exopolysaccharides are high molecular weight compounds consisting of monosaccharide residues and their derivatives, which have biological activity and play a protective role in physiological processes. The search for strains of lactic acid bacteria producing exopolysaccharides is a promising area of research due to their proven positive effect on the rheological properties of fermented food products, as well as human health.

Purpose: To study the ability of lactic acid bacteria strains from the collection of FGANU NIIHP to produce exopolysaccharides, as well as to compare different methods of their determination - gravimetric, phenol-sulfuric acid Dubois method, anthrone reagent method and titrimetric Bertrand method.

Materials and Methods: To determine the ability to produce exopolysaccharides, cultures of lactic acid bacteria were cultured on 12% malt mash for 48 hours at the optimum temperature for each strain. After protein removal and dialysis, the amount of exopolysaccharides was determined in the culture fluid by different methods.

Results: It was found that all the collection strains formed exopolysaccharides in different amounts. The strains producing the highest amount of exopolysaccharides were identified as L.amilolyticus-2, L. plantarumA-63(d), L.amilolyticus-1, L.brevis-78(d), L. paracasei-6. The yield of the product containing exopolysaccharides produced by lactic acid bacteria ranged from 7 to 14.4 mg in 1 ml of culture liquid. The results of the study allowed us to conclude the correctness of Dubois method for estimating the content with respect to exopolysaccharides produced by lactic acid bacteria.

Conclusion: The conducted studies confirm the ability of strains of lactic acid bacteria, from the collection of FGANU NIIHP, to produce exopolysaccharides. The correctness of the Dubois method for the determination of exopolysaccharides produced by lactic acid bacteria was established.
The Future of Population Screening and Virtual Cancer Screening
Authors: Комаров Юрий Игоревич , Беляев Алексей Михайлович , Хилько Наталья Николаевна , Ускова Арина Игоревна , Денисова Дарья Алексеевна , Каспаров Борис Сергеевич , Андрейченко Анна Евгеньевна , Хайлова Жанна Владимировна , Каприн Андрей Дмитриевич , Омельяновский Виталий Владимирович
Published: January 2025

Онкологические заболевания остаются одной из ведущих причин заболеваемости и смертности в мире. Программы скрининга рака молочной железы, шейки матки и колоректального рака доказали свою эффективность в снижении смертности. Однако их успех часто ограничивается доступностью ресурсов, охватом целевой группы населения и способностью системы здравоохранения к лечению пациентов с ранними формами заболеваний. Организованный скрининг, опирающийся на четкие протоколы, стандартизированные интервалы и постоянный мониторинг, представляет собой эффективный подход, однако требует значительных организационных и финансовых усилий. С развитием цифровых технологий возникает новая парадигма — виртуальный скрининг. Эта концепция предполагает использование данных, полученных вне рамок организованных программ, таких как результаты инструментальной диагностики и лабораторных исследований для выявления групп риска и оптимизации стратегий скрининга. Виртуальный скрининг позволяет интегрировать разрозненные данные с помощью технологий машинного обучения и искусственного интеллекта, обеспечивая более точную и персонализированную оценку рисков. Это открывает новые возможности для повышения эффективности и доступности скрининговых программ, особенно в условиях ограниченных ресурсов. Данная статья акцентирует внимание на важности организованного скрининга и потенциале виртуального скрининга как его дополнения. Обсуждаются ключевые вызовы традиционных программ и пути их преодоления с помощью современных технологий: внедрение искусственного интеллекта и анализа больших данных для повышения эффективности, улучшения прогнозов пациентов и снижения экономического бремени на систему здравоохранения.
The Role of Sentinel Lymph Node Biopsy in Breast Cancer Patients After Neoadjuvant Chemotherapy. Literature review
Authors: Решетов Игорь Владимирович , Хакимова Гулноз Голибовна , Зикиряходжаев Азиз Дилшодович , Мошурова Марианна Валентиновна , Хакимова Шахноз Голибовна , Джантемирова Назгуль Маратовна , Казарян Людмила Павловна , Тимошкин Владислав Олегович
Published: January 2025

Применение биопсии «сторожевого» лимфатического узла (БСЛУ) при раке молочной железы (РМЖ) представляет собой минимально травматичную манипуляцию, которая является золотым стандартом диагностики регионарного лимфоколлектора и альтернативой аксиллярной лимфодиссекции, что позволяет избежать, в первую очередь, таких осложнений как контрактура плечевого сустава, лимфедема руки. Данный обзор литературы направлен на анализ результатов БСЛУ у пациентов с первоначально cN+ статусом РМЖ, у которых после неоадъювантной химиотерапии (НАХТ) наблюдалась конверсия аксиллярных лимфатических узлов (ycN0). В ходе исследования проанализированы публикации в базах данных: PubMed и Cochrane, а также отечественные работы, за период с января 2019 года по декабрь 2023 года. Частота ложноотрицательных результатов БСЛУ у пациентов с исходным сN+ статусом после НАХТ составила не более 19,3%. При анализе влияния количества удаляемых сторожевых лимфатических узлов на выживаемость без прогрессирования и безрецидивную выживаемость при условии достижения ycN0 после НАХТ закономерностей выявлено не было. Размер остаточной опухоли в молочной железе ≥ 5 мм и лимфоваскулярная инвазия были признаны независимыми факторами риска вовлечения несторожевых аксиллярных лимфатических узлов, а достижение полного патоморфологического ответа в молочной железе - фактором повышающим возможность достижения полного патоморфологического ответа в регионарных лимфатических узлах и статистически значимо увеличивающим общую выживаемость. Анализ безрецидивной выживаемости у пациентов в группе с конверсией лимфатических узлов при сравнении с группой с исходным cN0 статусом, которым выполнили БСЛУ после лекарственного лечения не выявил статистически значимых различий. Частота локорегионарных рецидивов в обоих когортах составила не более 4,1% за период наблюдения равный 5 годам. Таким образом выбор в пользу БСЛУ после НАХТ улучшает показатели качества жизни больных РМЖ без снижения общей и безрецидивной выживаемости.
Epidemiological Features of Cutaneous Melanoma in the Siberian Federal District
Authors: Богданова Вероника Александровна , Жуйкова Лилия Дмитриевна , Кононова Галина Александровна , Ананина Ольга Александровна , Спирина Людмила Викторовна , Чижевская Светлана Юрьевна
Published: January 2025

Введение. Меланома кожи — злокачественная опухоль, возникающая в результате трансформации меланоцитов — клеток, отвечающих за образование пигмента в коже. Согласно ВОЗ, за последние десятилетия распространенность меланомы значительно увеличилась, особенно в странах, где преобладает население со светлым типом кожи. Исходя из территориальных особенностей РФ, показатели заболеваемости имеют отличия в разных регионах страны. Для разработки территориальных противораковых программ в Сибирском Федеральном округе, в т. ч. по профилактике меланомы, актуальной задачей становится оценка показателей заболеваемости и смертности, а также онкологической помощи населению.
Материалы и методы. За основу были взяты годовые отчетные формы федерального статистического наблюдения № 7 и № 35 по региону и его 10 субъектам за 2013-2022 гг., и сведения о численности и составе населения по полу и возрасту по данным Федеральной службы государственной статистики. Стандартизованные и интенсивные («грубые») показатели заболеваемости были рассчитаны прямым методом. Показатели качества оказания онкологической помощи оценивались согласно методическим рекомендациям НИИ им. П.А. Герцена. В динамике по годам показатели оценивались с помощью регрессионного анализа на уровне p ≤ 0,05.
Результаты. В 2022 г. в СФО было зарегистрировано 1 273 новых случаев меланомы кожи, из них 37,5 % пришлось на мужчин, и 62,5 % — на женщин. Согласно полученным результатам, доля больных меланомой кожи в структуре онкологической заболеваемости СФО выше у женщин, чем у мужчин, как и по показателю заболеваемости в целом (СП женщины — 4,9 0/0000; мужчины — 4,4 0/0000), однако за период исследования отмечено значимое увеличение заболеваемости среди мужского населения. За изучаемый отрезок времени в СФО выросли показатели активной выявляемости и ранней диагностики меланомы кожи.
Выводы. Анализ эпидемиологической ситуации в отношении меланомы кожи на территории СФО показал аналогичный России в целом рост заболеваемости среди мужского населения, увеличение числа случаев среди мужчин в возрасте от 45 до 49 лет. За период с 2013 по 2022 гг. показатель смертности населения оставался на одном уровне.
Evaluation of the Potential of Hybrid Tri-Component Nanosystems Based on Selenium Nanoparticles, Graft Copolymers and Radachlorin for Targeted Tumor Delivery
Authors: Валуева Светлана Валерьевна , Панченко Андрей Владимирович , Морозова Полина Юрьевна , Семенов Александр Леонидович , Данилова Анна Борисовна , Попович Ирина Григорьевна , Круглов Степан Сергеевич
Published: January 2025

Введение. В качестве перспективных наноструктурированных материалов для адресной доставки лекарственных веществ рассматриваются сополимеры с полиимидной или целлюлозной основной цепью и боковыми цепями полиметакриловой кислоты. В работе проведена оценка in vitro и in vivo накопления в опухоли гибридных трехкомпонентных наносистем на основе наночастиц селена, графт-сополимеров с полиимидной (ГТН-1) или целлюлозной (ГТН-3) основной цепью и боковыми цепями полиметакриловой кислоты, и фотосенсибилизатора Радахлорина.
Материалы и методы. Накопление и локализация ГТН-1 и ГТН-3 в опухолевых клетках оценены методом флуоресцентной конфокальной микроскопии в культуре клеток мышечно-неинвазивного рака мочевого пузыря человека через 24 ч. инкубации и у мышей линии BALB/c с внутрикожно перевитой опухолью Эрлиха методом флуоресцентной визуализации системой Fluor i In Vivo через 1, 2, 3, 4, 6 и 24 ч. после внутривенного введения исследуемых веществ. С помощью программы ImageJ оценивали контраст флуоресцентного сигнала опухоль/тело.
Результаты. Анализ конфокальных изображений продемонстрировал накопление обеих наносистем в цитоплазме злокачественных клеток, которое было сопоставимо с накоплением Радахлорина. В опухоли Эрлиха у мышей интенсивность флуоресценции наносистем и Радахлорина была выше, чем в окружающей ткани спустя 6 и 24 ч. после внутривенного введения. Контраст флуоресценции опухоль/ткань увеличивался после введения, достигнув пиковых значений 1,4 для Радахлорина, спустя 4 ч., 1,5 для ГТН-1 через 4–6 ч. и 1,4 через 6–24 ч. после введения ГТН-3. Увеличение времени достижения пикового значения контраста опухоль/ткань связано с изменением фармакокинетических свойств при включении Радахлорина в наносистемы.
Выводы. Гибридные трехкомпонентные наносистемы с полиимидной или целлюлозной основными цепями эффективно накапливаются в опухолевых клетках, обеспечивают замедление выведения из опухоли, что определяет перспективность разработки на их основе препаратов направленной доставки для лечения и диагностики онкологических заболеваний.
The Spectrum of Uncommon EGFR Mutations in Non-Small Cell Lung Cancer
Authors: Михеев Дмитрий Владимирович , Чернякова Александра Павловна , Митюшкина Наталья Владимировна , Тюрин Владислав Ильич , Никитина Алиса Сергеевна , Асадулаева Каримат Амирхановна , Иевлева Аглая Геннадиевна , Имянитов Евгений Наумович
Published: January 2025

Введение. Активирующие мутации в гене рецептора эпидермального фактора роста (EGFR) — одна из основных мишеней таргетной терапии при немелкоклеточном раке легкого (НМРЛ). Более 80 % всех мутаций EGFR составляют делеции в 19 экзоне и замена L858R. Оставшиеся 15-20 % представлены большим разнообразием более редких соматических вариантов EGFR. Редкие мутации менее изучены и связаны с разной чувствительностью к анти-EGFR терапии.
Цель. Анализ спектра редких мутаций в гене EGFR при НМРЛ у российских больных.
Материалы и методы. Исследуемую группу составили 3 187 случаев НМРЛ. В гистологическом опухолевом материале был выполнен поиск делеций в 19 экзоне, замен L858R, инсерций в 20 экзоне, миссенс-мутаций T790M, L861Q, S768I и G719X в гене EGFR при помощи комбинации ПЦР-методов и секвенирования по Сэнгеру.
Результаты. Мутации EGFR были обнаружены у 497 (15,6 %) пациентов. Варианты ex19del и L858R присутствовали в 425 из 497 (85,5 %) EGFR-позитивных случаев. Среди редких мутаций преобладали инсерции в 20 экзоне (44,9 %) и двойные мутации, представленные сочетанием двух редких или редкого и частого вариантов (25,6 %). Замены G719X и S768I обнаруживались преимущественно в комбинациях с другими вариантами. Частота мутаций EGFR была выше у женщин и у некурящих пациентов. Вместе с тем среди больных с редкими мутациями доля женщин оказалась значительно ниже, чем при НМРЛ с частыми мутациями (60,3 % и 78,7 % соответственно, p = 0,0005). Также для случаев с редкими мутациями оказался характерен более молодой возраст (p = 0,009).
Выводы. Доля редких вариантов в гене EGFR при НМРЛ составляет около 15 %, значительная часть из них приходится на инсерции в 20 экзоне EGFR. В 5 % всех НМРЛ с мутациями наблюдаются сочетания двух разных вариантов (двойные мутации). Редкие варианты EGFR чаще, чем делеции в 19 экзоне или замена L858R, встречаются у мужчин и у более молодых пациентов.