bluuebunny/crossref_metadata_2025 huggingface dataset:
Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior
Authors: Chu Yu-Hsuan , Lin Jia-di , Nath Suvra , Schachtrup Christian
Published: July 2021

Neural stem/progenitor cells (NSPCs) are found in the adult brain and spinal cord, and endogenous or transplanted NSPCs contribute to repair processes and regulate immune responses in the CNS. However, the molecular mechanisms of NSPC survival and integration as well as their fate determination and functionality are still poorly understood. Inhibitor of DNA binding (Id) proteins are increasingly recognized as key determinants of NSPC fate specification. Id proteins act by antagonizing the DNA-binding activity of basic helix-loop-helix (bHLH) transcription factors, and the balance of Id and bHLH proteins determines cell fate decisions in numerous cell types and developmental stages. Id proteins are central in responses to environmental changes, as they occur in CNS injury and disease, and cellular responses in adult NSPCs implicate Id proteins as prime candidates for manipulating stemcell behavior. Here, we outline recent advances in understanding Id protein pleiotropic functions in CNS diseases and propose an integrated view of Id proteins and their promise as potential targets in modifying stemcell behavior to ameliorate CNS disease.
Positive energy static solutions for the Chern–Simons–Schrödinger system under a large-distance fall-off requirement on the gauge potentials
Authors: Azzollini Antonio , Pomponio Alessio
Published: July 2021

In this paper we prove the existence of a positive energy static solution for the Chern–Simons–Schrödinger system under a large-distance fall-off requirement on the gauge potentials. We are also interested in existence of ground state solutions.
Sharp conditions for the linearization of finite elasticity
Authors: Mainini Edoardo , Percivale Danilo
Published: July 2021

We consider the topic of linearization of finite elasticity for pure traction problems. We characterize the variational limit for the approximating sequence of rescaled nonlinear elastic energies. We show that the limiting minimal value can be strictly lower than the minimal value of the standard linear elastic energy if a strict compatibility condition for external loads does not hold. The results are provided for both the compressible and the incompressible case.
Determination of the spherical part of the couple-stress in a polar fibre-reinforced elastic plate subjected to pure bending
Authors: Soldatos K. P.
Published: July 2021

This communication provides initial information and understanding of the manner in which a newly developed theoretical mechanism (Soldatos in Int J Solids Struct 202:217–225, 2020) is applied in specific boundary value problems met in polar linear elasticity of fibrous composites and thus enables the determination of the spherical part of the couple-stress tensor. In this context, it tests the applicability of the implied mechanism/method in the case that a rectangular plate reinforced by a single family of unidirectional fibres is subjected to pure bending. The problem solution is obtained for either non-polar or polar material behaviour, where fibres are considered perfectly flexible or resistant in bending, respectively, and provides clear evidence of the correctness of the principal argument that underpins the proposed method. Namely, that the general rotation field of the plate deformation differs from the fibre rotation field. That newly discovered method enables an extra energy term that emerges in the strain energy function of the fibrous composite plate to relate with the spherical part of the couple-stress tensor outside conventional equilibrium conventions. It thus leads to the determination of the spherical part of the couple-stress and its distribution throughout the plate body in a complete and comprehensive manner.
DEER Spectroscopy of Channelrhodopsin-2 Helix B Movements in Trapped Photocycle Intermediates
Authors: Schumacher Magdalena , Klare Johann P. , Bamann Christian , Steinhoff Heinz-Jürgen
Published: July 2021

The light-gated dimeric cation channel channelrhodopsin-2 (ChR2) has been established as one of the most important optogenetic tools. During its functional cycle, ChR2 undergoes conformational changes, the most prominent ones include a movement of transmembrane helix B. In the present work, we assign this movement to a trapped photocycle intermediate using DEER spectroscopy combined with sample illumination inside the microwave resonator, allowing trapping and relaxation of defined ChR2 intermediates at different temperatures between 180 and 278 K. Intradimer distances measured between spin-labeled positions 79 located in helix B of ChR2 in the dark state and upon light activation and relaxation at 180 K were similar. In contrast, light activation at 180 K and 30 min relaxation at between 230 and 255 K results in significant changes of the distance distribution. We show that the light-induced movement of helix B is correlated with the presence of the P480 state of ChR2. We hypothesize that conformational changes occurring in this area are key elements responsible for desensitizing the channel for cation conduction.
Efficacy of superselective transcatheter arterial embolization for intractable postpartum hemorrhage due to genital tract trauma after vaginal delivery
Authors: Sasaki Koji , Okada Takuya , Yamaguchi Masato , Ahmed Mostafa , Gentsu Tomoyuki , Ueshima Eisuke , Sofue Keitaro , Tanimura Kenji , Yamada Hideto , Sugimoto Koji , Murakami Takamichi
Published: July 2021

Purpose

To evaluate the efficacy of superselective transcatheter arterial embolization (TAE) for intractable postpartum hemorrhage (PPH) due to genital tract trauma (GTT) after vaginal delivery.

Methods

We evaluated 27 patients who underwent TAE for intractable PPH due to GTT after vaginal delivery at our institution between January 2008 and December 2020. Patients were divided into two groups according to TAE procedure; TAE performed as close as possible to the bleeding point, at least more peripherally than the second branch of the anterior division of the internal iliac artery, was defined as superselective TAE (S-TAE). TAE performed from the proximal segment of the internal iliac artery was defined as proximal TAE (P-TAE). Patient characteristics, pre-procedural contrast-enhanced computed tomography (CE-CT), procedure details, technical/clinical success, and complications were evaluated separately for the S-TAE and P-TAE groups.

Results

The combined technical/clinical success rate was 92%. No major procedure-related complications were seen (mean follow-up: 6.12 ± 3.93 days). The combined technical/clinical success rate of S-TAE was 100% and of P-TAE was 67% (p = 0.04). S-TAE was performed more frequently in patients with pre-procedural CE-CT (p = 0.01) and use of permanent embolic materials (p = 0.003).

Conclusion

S-TAE is safe and effective for intractable PPH due to GTT. Pre-procedural CE-CT may be useful for detecting the culprit artery and be helpful in performing S-TAE.
Climate tolerances of Philaenus spumarius should be considered in risk assessment of disease outbreaks related to Xylella fastidiosa
Authors: Godefroid M. , Morente M. , Schartel T. , Cornara D. , Purcell A. , Gallego D. , Moreno A. , Pereira J. A. , Fereres A.
Published: July 2021

The bacteriumXylella fastidiosa(Xf) is an invasive insect-borne pathogen, which causes lethal diseases to important crops including olives, citrus, almonds and grapes as well as numerous forest, ornamental, and uncultivated plants. Outbreaks ofXf-related plant diseases are currently occurring in the Mediterranean region, causing substantial losses to various agricultural sectors. Several models have recently been published to identify which regions are at highest risk in Europe; however, such models did not consider the insect vectors, which constitute the key driver of short-rangeXfspread. We fitted bioclimatic species distribution models to depict the macroclimatic preferences of the meadow spittlebugPhilaenus spumariusL. (1978) (Hemiptera: Aphrophoridae), the major epidemiologically relevant vector currently responsible forXfspread in the Europe. Many regions of Western Europe and Mediterranean basin are predicted by models as highly climatically suitable for this vector, including all regions where severeXfhave occurred so far. Conversely, the driest and warmest areas of the Mediterranean basin are predicted as little suitable forP. spumarius. Models forecast that agricultural-important parts of the southern Mediterranean area might experience a substantial decrease in climatic suitability forP. spumariusby the period 2040–2060. Areas predicted as highly suitable just for the bacterium but not optimal for this vector are apparently still free of severeXfoutbreaks, suggesting that climate tolerances ofP. spumariusmight partly explain the current spatial pattern ofXfoutbreaks in Europe and should always be considered in further risk assessments.
A cross-sectional survey of general practitioner knowledge, attitudes, and clinical experience of HIV PrEP
Authors: North Sarah , Sandset Tony Joakim , Olsen Anne Olaug
Published: July 2021

Aim

Norway’s health scheme provides no-cost HIV pre-exposure prophylaxis (PrEP) when prescribed by a specialist, typically preceded by a general practitioner’s (GP) referral. The GP perspective with regard to PrEP implementation in Norway has yet to be captured.

Subject and methods

We explored PrEP knowledge, attitudes, and clinical experience of GPs in the Norwegian capital of Oslo, where HIV incidence and PrEP demand are highest. An anonymous survey was designed and distributed between November 2019 and February 2020. Univariate and multivariate logistic regression analyses were performed to identify determinants of GPs’ previous clinical PrEP experience (PrEP adoption).

Results

One hundred and seventeen GPs responded to the survey. GP PrEP adopters were more likely to: identify as men (aOR 2.1; 95% CI: 1.0–4.5); identify as lesbian, gay, or bisexual (LGB) (aOR 4.4; 95% CI: 1.4–14.5); have ≥ 10 LGB identifying patients on their list (aOR 4.4; 95% CI:1.8–10.4); and self-report higher levels of PrEP knowledge (aOR 2.4; 95% CI: 1.3–4.4).

Conclusion

Our findings suggest that GP PrEP knowledge is crucial to patient PrEP access. Educational interventions ought to be considered to enhance GP PrEP adoption capacities, such as easy-to-access PrEP guidelines and peer-based training opportunities in both online and in-person formats.
Acceptability and Preferences of Two Different Community Models of ART Delivery in a High Prevalence Urban Setting in Zambia: Cluster-Randomized Trial, Nested in the HPTN 071 (PopART) Study
Authors: Limbada Mohammed , Bwalya Chiti , Macleod David , Shibwela Osborn , Floyd Sian , Nzara Diana , Situmbeko Vasty , Hayes Richard , Fidler Sarah , Ayles Helen ,   the HPTN 071 (PopART) Study Team
Published: July 2021

Community delivery of Antiretroviral therapy (ART) is a novel innovation to increase sustainable ART coverage for People living with HIV (PLHIV) in resource limited settings. Within a nested cluster-randomised sub-study in two urban communities that participated in the HPTN 071 (PopART) trial in Zambia we investigated individual acceptability and preferences for ART delivery models. Stable PLHIV were enrolled in a cluster-randomized trial of three different models of ART: Facility-based delivery (SoC), Home-based delivery (HBD) and Adherence clubs (AC). Consenting individuals were asked to express their stated preference for ART delivery options. Those assigned to the community models of ART delivery arms could choose (“revealed preference”) between the assigned arm and facility-based delivery. In total 2489 (99.6%) eligible individuals consented to the study and 95.6% chose community models of ART delivery rather than facility-based delivery when offered a choice. When asked to state their preference of model of ART delivery, 67.6% did not state a preference of one model over another, 22.8% stated a preference for HBD, 5.0% and 4.6% stated a preference for AC and SoC, respectively. Offering PLHIV choices of community models of ART delivery is feasible and acceptable with majority expressing HBD as their stated preferred option.
Microstructural evolution and mechanical properties of FeCoCrNiCu high entropy alloys: a microstructure-based constitutive model and a molecular dynamics simulation study
Authors: Luo Gangjie , Li Li , Fang Qihong , Li Jia , Tian Yuanyuan , Liu Yong , Liu Bin , Peng Jing , Liaw P. K.
Published: July 2021

High entropy alloys (HEAs) attract remarkable attention due to the excellent mechanical performance. However, the origins of their high strength and toughness compared with those of the traditional alloys are still hardly revealed. Here, using a microstructure-based constitutive model and molecular dynamics (MD) simulation, we investigate the unique mechanical behavior and microstructure evolution of FeCoCrNiCu HEAs during the indentation. Due to the interaction between the dislocation and solution, the high dislocation density in FeCoCrNiCu leads to strong work hardening. Plentiful slip systems are stimulated, leading to the good plasticity of FeCoCrNiCu. The plastic deformation of FeCoCrNiCu is basically affected by the motion of dislocation loops. The prismatic dislocation loops inside FeCoCrNiCu are formed by the dislocations with the Burgers vectors of $${a \over 6}\left[ {\bar 11\bar 2} \right]$$

a
6

[

1
¯

1

2
¯

]

and $${a \over 6}\left[ {1\bar 12} \right]$$

a
6

[

1

1
¯

2

]

, which interact with each other, and then emit along the 〈111〉 slip direction. In addition, the mechanical properties of FeCoCrNiCu HEA can be predicted by constructing the microstructure-based constitutive model, which is identified according to the evolution of the dislocation density and the stress-strain curve. Strong dislocation strengthening and remarkable lattice distortion strengthening occur in the deformation process of FeCoCrNiCu, and improve the strength. Therefore, the origins of high strength and high toughness in FeCoCrNiCu HEAs come from lattice distortion strengthening and the more activable slip systems compared with Cu. These results accelerate the discovery of HEAs with excellent mechanical properties, and provide a valuable reference for the industrial application of HEAs.
Interfacial instability of ferrofluid flow under the influence of a vacuum magnetic field
Authors: Li Mingjun , Zhu Li
Published: July 2021

This study is to numerically test the interfacial instability of ferrofluid flow under the presence of a vacuum magnetic field. The ferrofluid parabolized stability equations (PSEs) are derived from the ferrofluid stability equations and the Rosensweig equations, and the characteristic values of the ferrofluid PSEs are given to describe the ellipticity of ferrofluid flow. Three numerical models representing specific cases considering with/without a vacuum magnetic field or viscosity are created to mathematically examine the interfacial instability by the computation of characteristic values. Numerical investigation shows strong dependence of the basic characteristic of ferrofluid Rayleigh-Taylor instability (RTI) on viscosity of ferrofluid and independence of the vacuum magnetic field. For the shock wave striking helium bubble, the magnetic field is not able to trigger the symmetry breaking of bubble but change the speed of the bubble movement. In the process of droplet formation from a submerged orifice, the collision between the droplet and the liquid surface causes symmetry breaking. Both the viscosity and the magnetic field exacerbate symmetry breaking. The computational results agree with the published experimental results.
The impacts of biofuel crops on local biodiversity: a global synthesis
Authors: Tudge Sophie Jane , Purvis Andy , De Palma Adriana
Published: July 2021

Concerns about the impacts of climate change have led to increased targets for biofuel in the global energy market. First-generation biofuel crops contain oil, sugar or starch and are usually also grown for food, whereas second-generation biofuel is derived from non-food sources, including lignocellulosic crops, fast-growing trees, crop residues and waste. Biofuel production drives land-use change, a major cause of biodiversity loss, but there is limited knowledge of how different biofuel crops affect local biodiversity. Therefore, a more detailed understanding could inform more environmentally-conscious decisions about where to grow which biofuel crops. We synthesised data from 116 sources where a potential biofuel crop was grown and estimated how two measures of local biodiversity, species richness and total abundance, responded to different crops. Local species richness and abundance were 37% and 49% lower at sites planted with first-generation biofuel crops than in sites with primary vegetation. Soybean, wheat, maize and oil palm had the worst effects; the worst affected regions were Asia and Central and South America; and plant species richness and vertebrate abundance were the worst affected biodiversity measures. Second-generation biofuels had smaller, but still significant, effects: species richness and abundance were 19% and 25%, respectively, lower in such sites than in primary vegetation. Our models suggest that land clearance to cultivate biofuel crops reduces local biodiversity. However, the yield of biofuel from different crops influences the biodiversity impacts per unit of energy generated, and the geographic and taxonomic variation in effects are also relevant for making sustainable land-use decisions.
Agency and the Successive Structure of Time-Consciousness
Authors: McKenna Camden Alexander
Published: July 2021

I argue for constraining the nomological possibility space of temporal experiences and endorsing the Succession Requirement for agents. The Succession Requirement holds that the basic structure of temporal experience must be successive for agentive subjects, at least in worlds that are law-like in the same way as ours. I aim to establish the Succession Requirement by showing non-successively experiencing agents are not possible for three main reasons, namely that they (1) fail to stand in the right sort of causal relationship to the outcomes of their actions, (2) exhibit the wrong sort of epistemic status for agency, and (3) lack the requisite agentive mental attitude of intentionality. I conclude that agency is incompatible with non-successive experience and therefore we should view the successive temporal structure of experience as a necessary condition for agency. I also suggest that the Succession Requirement may actually extend beyond my main focus on agency, offering preliminary considerations in favor of seeing successive experience as a precondition for selfhood as well. The consequences of the Succession Requirement are wide-ranging, and I discuss various implications for our understanding of agency, the self, time consciousness, and theology, among other things.
Long-Term Treatment Outcomes of PEERS® for Preschoolers: A Parent-Mediated Social Skills Training Program for Children with Autism Spectrum Disorder
Authors: Tripathi Isita , Estabillo Jasper A. , Moody Christine T. , Laugeson Elizabeth A.
Published: July 2021

Although parent-assisted social skills interventions may reduce early social challenges in preschool-aged children with autism spectrum disorder (ASD), limited research has explored whether intervention gains maintain several years after treatment. This study examined the durability of PEERS® for Preschoolers, a parent-mediated social skills training program for preschool-aged children with ASD and other social challenges. Twenty-nine parents reported on child and family outcomes 1–5 years following treatment. Results demonstrated maintenance of treatment gains on measures of ASD-related social impairments including social communication, social responsiveness, social motivation, and peer engagement. Post-treatment improvements in problem behaviors and parenting stress were not maintained at long-term follow-up. Implications of these results are discussed.
Superior Communication of Positive Emotions Through Nonverbal Vocalisations Compared to Speech Prosody
Authors: Kamiloğlu Roza G. , Boateng George , Balabanova Alisa , Cao Chuting , Sauter Disa A.
Published: July 2021

The human voice communicates emotion through two different types of vocalizations: nonverbal vocalizations (brief non-linguistic sounds like laughs) and speech prosody (tone of voice). Research examining recognizability of emotions from the voice has mostly focused on either nonverbal vocalizations or speech prosody, and included few categories of positive emotions. In two preregistered experiments, we compare human listeners’ (total n = 400) recognition performance for 22 positive emotions from nonverbal vocalizations (n = 880) to that from speech prosody (n = 880). The results show that listeners were more accurate in recognizing most positive emotions from nonverbal vocalizations compared to prosodic expressions. Furthermore, acoustic classification experiments with machine learning models demonstrated that positive emotions are expressed with more distinctive acoustic patterns for nonverbal vocalizations as compared to speech prosody. Overall, the results suggest that vocal expressions of positive emotions are communicated more successfully when expressed as nonverbal vocalizations compared to speech prosody.
Muon Tomography of the Interior of a Reinforced Concrete Block: First Experimental Proof of Concept
Authors: Niederleithinger Ernst , Gardner Simon , Kind Thomas , Kaiser Ralf , Grunwald Marcel , Yang Guangliang , Redmer Bernhard , Waske Anja , Mielentz Frank , Effner Ute , Köpp Christian , Clarkson Anthony , Thomson Francis , Ryan Matthew , Mahon David
Published: July 2021

Quality assurance and condition assessment of concrete structures is an important topic world-wide due to the aging infrastructure and increasing traffic demands. Common topics include, but are not limited to, localisation of rebar or tendon ducts, geometrical irregularities, cracks, voids, honeycombing or other flaws. Non-destructive techniques such as ultrasound or radar have found regular, successful practical application but sometimes suffer from limited resolution and accuracy, imaging artefacts or restrictions in detecting certain features. Until the 1980s X-ray transmission was used in case of special demands and showed a much better resolution than other NDT techniques. However, due to safety concerns and cost issues, this method is almost never used anymore. Muon tomography has received much attention recently. Novel detectors for cosmic muons and tomographic imaging algorithms have opened up new fields of application, such as the investigation of freight containers. Muon imaging also has the potential to fill some of the gaps currently existing in concrete NDT. As a first step towards practical use and as a proof of concept we used an existing system to image the interior of a reference reinforced 600 kg concrete block. Even with a yet not optimized setup for this kind of investigation, the muon imaging results are at least of similar quality compared to ultrasonic and radar imaging, potentially even better. The data acquisition takes more time and signals contain more noise, but the images allowed to detect the same important features that are visible in conventional high energy X-ray tomography. In our experiment, we have shown that muon imaging has potential for concrete inspection. The next steps include the development of mobile detectors and optimising acquisition and imaging parameters.
The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters
Authors: Castagna Michela , Cinquetti Raffaella , Verri Tiziano , Vacca Francesca , Giovanola Matteo , Barca Amilcare , Romanazzi Tiziana , Roseti Cristina , Galli Alessandra , Bossi Elena
Published: July 2021

To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (Lepidopteran) Orthologs of the SLC6 family transporters have represented very important tools for investigating functional–structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts.
Model reduction of the tippedisk: a path to the full analysis
Authors: Sailer Simon , Leine Remco I.
Published: July 2021

Thetippediskis a mechanical-mathematical archetype for friction-induced instability phenomena that exhibits an interesting inversion phenomenon when spun rapidly. The inversion phenomenon of the tippedisk can be modeled by a rigid eccentric disk in permanent contact with a flat support, and the dynamics of the system can therefore be formulated as a set of ordinary differential equations. The qualitative behavior of the nonlinear system can be analyzed, leading to slow–fast dynamics. Since even a freely rotating rigid body with six degrees of freedom already leads to highly nonlinear system equations, a general analysis for the full system equations is not feasible. In a first step the full system equations are linearized around the inverted spinning solution with the aim to obtain a local stability analysis. However, it turns out that the linear dynamics of the full system cannot properly describe the qualitative behavior of the tippedisk. Therefore, we simplify the equations of motion of the tippedisk in such a way that the qualitative dynamics are preserved in order to obtain a reduced model that will serve as the basis for a following nonlinear stability analysis. The reduced equations are presented here in full detail and are compared numerically with the full model. Furthermore, using the reduced equations we give approximate closed form results for the critical spinning speed of the tippedisk.
Historical roots of entrepreneurship in different regional contexts—the case of Poland
Authors: Fritsch Michael , Pylak Korneliusz , Wyrwich Michael
Published: July 2021

Entrepreneurship is often found to be highly persistent over time. Although the historical roots of persisting effects of entrepreneurship are partially uncovered, their mechanisms remained largely unclear. To understand the historical roots of contemporaneous regional entrepreneurship, we exploit different types of historical self-employment in regions of Poland, a country that experienced different types of disruptive developments. In contrast to previous studies on other countries, we do not find a persistent effect of the general level of historical private sector self-employment. There is, however, a pronounced positive relationship between high regional levels of knowledge-intensive entrepreneurship in the 1920s and current start-up activity in general, even in areas where large parts of the local population were displaced after World War II. We find that the magnitude of this effect is independent of the mobility and an exchange of the local population. Our main conclusion is that the historical regional knowledge stock, as reflected by knowledge-intensive entrepreneurship, can be an important and stable historical root of modern entrepreneurship despite disruptive historical shocks and population discontinuities.
A bibliometric analysis of publications in Ambio in the last four decades
Authors: Ho Yuh-Shan , Gatto Andrea
Published: July 2021

Ambio is a leading journal in environmental science and policy, sustainable development, and human-environment interactions. The paper at hand aims to run a bibliometric analysis to inspect the main publications features of Ambio in Science Citation Index Expanded SCI-EXPANDED. For this scope, a bibliometric survey has been carried out to investigate the journal’s historic characteristics in the Web of Science (WoS) categories of environmental sciences and environmental engineering for Ambio from 1980 to 2019. These are the categories for which the journal has been indexed throughout the indexed time frame. The paper proposes technical and methodological innovations, including improvements in the methods and original characteristics analyzed. Documents published in Ambio were searched out from SCI-EXPANDED. Six publication indicators were applied to evaluate the publication performance of countries, institutes, and authors. Three citation indicators were used to compare publications. As a parameter, the journal impact factor contributor was applied to compare the most frequently cited publications. The journal impact factor contributing publications were also discussed. Results show that Sweden ranked top in six publication indicators and that the top three productive institutes were located in Sweden. A low percentage of productive authors emerged as a journal impact factor contributor. Similarly, a low relationship between the IF contributing publications and the highly cited publications was also found. Less than half of the top 100 highly cited publications in Ambio did not lie within the high impact in most the recent year of 2019. Three members of the advisory board in Ambio were the main productive authors. T.V. Callaghan contributed to most of the publications while papers published by J. Rockstrom as first and corresponding author contributed the most to the journal impact factor. An article authored by Steffen et al. (2007) scored the highest total citations in 2019.
Correction to: Trade and environmental pollution in Africa: accounting for consumption and territorial-based emissions
Authors: Adams Samuel , Opoku Eric Evans Osei
Published: July 2021

A Correction to this paper has been published: 10.1007/s11356-020-10328-8
A Dilemma for Globalized Safety
Authors: Zhao Bin
Published: July 2021

The safety condition is supposed to be a necessary condition on knowledge which helps to eliminate epistemic luck. It has been argued that the condition should be globalized to a set of propositions rather than the target proposition believed to account for why not all beliefs in necessary truths are safe. A remaining issue is which propositions are relevant when evaluating whether the target belief is safe or not. In the literature, solutions have been proposed to determine the relevance of propositions. This paper examines a case of luckily true belief—thus a case of ignorance—and a case of knowledge. It argues that no solution in the literature offers a correct verdict in either case. Therefore, the strategy to globalize safety remains unsatisfactory.
DDAA and Maternal Reflective Functions
Authors: Frolli Alessandro , Cavallaro Antonella , Oduro Stephen , Bosco Antonia , Lombardi Agnese , Di Carmine Francesca , Ricci Maria Carla
Published: July 2021

In this study, we propose to examine two types of Parent Training (PT) under DDAA —behavioral and reflective types of PT. The central idea of our work is that the development of parenting educational skills cannot ignore the development of reflective and regulatory functions, which promote pre-mentalization, social cognition, and empathic skills. Because of the lack of studies on the efficacy of behavioral PT addressed to the parents of subjects with DDAA, this work took place. This study included 90 families whose children were diagnosed with the disorder of dysregulated anger and aggression (DDAA) according to criteria of CD 0–5 (2016). The sample included pre-school children aged between 2 and 3 years old (age range 2–3 years), who were equally divided into two groups based on the type of PT administered to the parents or caregivers. Our results indicate that the PT intervention, which is focused on the improvement of parental reflexive functions, helps in obtaining greater results even in the reduction of the externalizing behavioral symptoms. Additionally, results show that the intervention of PT with a behavioral matrix does not improve parental reflexive functions even if it guarantees a slight reduction of children’s behavioral problems.
Development of New HS–SPME–GC–MS Technique to the Measurement of Volatile Terpenoid Profile of Milk
Authors: Székelyhidi Rita , Hanczné Lakatos Erika , Sik Beatrix , Ajtony Zsolt
Published: July 2021

This study presented the development of such a HS–SPME–GC–MS technique, with the use of which, directly from the raw milk sample matrix, both qualitatively and quantitatively; the volatile terpenoids (α-pinene, sabinene, β-pinene, p-cymene, limonene, linalool, α-thujene, camphor, menthol, methyl chavicol, caryophyllene E, α-humulene) can be determined, derived from herbs eaten by the dairy animals by different feeding methods. Repeatability was less than 10% in the case of milk fat samples. The estimated limits of quantitation were between 2 and 16 ng/g. The lowest values were 2 ng/g for p-cymene and methyl chavicol; the highest value was 16 ng/g for caryophyllene. In the case of goat milk, the repeatability was better than 8% except for α-thujene. The estimated limits of quantitation were between 1 and 8 ng/g. The lowest values were 1 ng/g for β-pinene, p-cymene and limonene, and the highest value was 8 ng/g for linalool. In milk fat, the highest concentration was identified in caryophyllene E (470 ng/g) and α-humulene (430 ng/g), while the lowest concentration was in p-cymene (2 ng/g) and camphor (2 ng/g). In goat milk, limonene was present in all samples, but its amount varied depending on the type of consumed herb. Methyl chavicol and caryophyllene E were detected in goat’s milk only in one case. The former was detected in sage milk at 2.09 ng/g and the latter in tarragon milk at 2.28 ng/g. We have also successfully demonstrated that the feed consumed by dairy animals also affects the quality of dairy products.
Recent Developments of Antimony-Based Anodes for Sodium- and Potassium-Ion Batteries
Authors: Chen Bochao , Liang Ming , Wu Qingzhao , Zhu Shan , Zhao Naiqin , He Chunnian
Published: July 2021

The development of sodium-ion (SIBs) and potassium-ion batteries (PIBs) has increased rapidly because of the abundant resources and cost-effectiveness of Na and K. Antimony (Sb) plays an important role in SIBs and PIBs because of its high theoretical capacity, proper working voltage, and low cost. However, Sb-based anodes have the drawbacks of large volume changes and weak charge transfer during the charge and discharge processes, thus leading to poor cycling and rapid capacity decay. To address such drawbacks, many strategies and a variety of Sb-based materials have been developed in recent years. This review systematically introduces the recent research progress of a variety of Sb-based anodes for SIBs and PIBs from the perspective of composition selection, preparation technologies, structural characteristics, and energy storage behaviors. Moreover, corresponding examples are presented to illustrate the advantages or disadvantages of these anodes. Finally, we summarize the challenges of the development of Sb-based materials for Na/K-ion batteries and propose potential research directions for their further development.
Temporal and Spatial Accretion Patterns and the Impact of Livestock Grazing in a Restored Coastal Salt Marsh
Authors: Koppenaal E. C. , Esselink P. , van Duin W. E. , Bakker J. P.
Published: July 2021

A summer polder had developed a deficit in surface elevation of about 20 cm in respect to rising sea level during its almost one-hundred-year period of embankment. We addressed the questions whether the distance of the restored site to the intertidal flats and continuation of livestock grazing in the restored site could hamper surface-elevation change during the first 10 years after de-embankment of the summer polder. The surface-elevation change showed similar positive linear relationships with annual tidal flooding in both the reference salt marsh and the restored site, indicating that the surface-elevation change in the restored site was not moderated by the distance from the sea. The surface-elevation change had a clear seasonal pattern with positive values in winter and negative values during summer. The surface-elevation change was 11 mm/year in the grazed reference salt marsh and 7 mm/year in the grazed restored site, but amounted to 17 mm/year in ungrazed exclosures in the restored site, showing that grazing retarded the catching up of the elevation deficit in the restored site. The surface-elevation change within the restored site was higher close to the constructed creeks indicating the inception of levee formation. The surface-elevation change was also positively affected by the proximity of breaches in the embankment, but this effect was less clear than the effect of creeks. We conclude that the surface-elevation deficit may be compensated in the Wadden Sea summer polders by their de-embankment when sediment supply is high, whereas livestock grazing retards this process. Dug creeks increase spatial variation in the restored site.
TP53 signature diagnostic system using multiplex reverse transcription–polymerase chain reaction system enables prediction of prognosis of breast cancer patients
Authors: Takahashi Shin , Fukui Takafumi , Nomizu Tadashi , Kakugawa Yoichiro , Fujishima Fumisyoshi , Ishida Takanori , Ohuchi Noriaki , Ishioka Chikashi
Published: July 2021

Background

TP53 status based on TP53 signature, a gene expression profile to determine the presence or absence of TP53 mutation, is an independent prognostic factor of breast cancer. The purpose of this study was to develop a simple diagnostic system for TP53 signature status.

Methods

We developed a multiplex reverse transcription–polymerase chain reaction system to determine TP53 status. Based on this system, prospectively collected 189 patients with stage I and II breast cancer were determined to have TP53 mutant signature or TP53 wild-type signature. The prognostic significance of the TP53 signature by the diagnostic system was analyzed.

Results

The diagnostic accuracy of TP53 status and reproducibility of this diagnosis system was confirmed. Using the diagnostic system, 89 patients were classified as TP53 mutant signature and the remaining 100 cases were classified as TP53 wild-type signature. Recurrence-free survival (RFS) among patients with TP53 mutant signature was significantly shorter than that among those with TP53 wild-type signature. On univariate and multivariate analyses, the TP53 signature status was an independent predictor of RFS. RFS among patients with TP53 mutant signature was significantly shorter than that among those with TP53 wild-type signature in a cohort of estrogen receptor-positive breast cancer. Although a difference was not significant, no recurrent cases was observed in TP53 wild-type signature group in triple negative breast cancer.

Conclusion

This simple and precise diagnostic system to determine TP53 signature status may help in prognostic assessment, therapeutic decision-making, and treatment optimization in patients with breast cancer.
Discussion on Competition for Spatial Statistics for Large Datasets
Authors: Flury Roman , Furrer Reinhard
Published: July 2021

We discuss the experiences and results of the AppStatUZH team’s participation in the comprehensive and unbiased comparison of different spatial approximations conducted in the Competition for Spatial Statistics for Large Datasets. In each of the different sub-competitions, we estimated parameters of the covariance model based on a likelihood function and predicted missing observations with simple kriging. We approximated the covariance model either with covariance tapering or a compactly supported Wendland covariance function.
LncRNA SNHG20 promotes cell proliferation and invasion by suppressing miR-217 in ovarian cancer
Authors: Xing Xuefeng , An Ming , Chen Tonghua
Published: July 2021

Background

Ovarian cancer is the most common female gynecological malignancy. SNHG20, as a long non-coding RNA, has been proven to be an important regulator in the occurrence and development of various tumors. However, the potential mechanism of SNHG20 in ovarian cancer is unclear.

Objective

The present study was aimed to investigate the functions and mechanisms of SNHG20 in ovarian cancer.

Methods

The expression of SNHG20 and miR-217 in ovarian cancer tissues and cell lines was detected by qRT-PCR. CCK-8 assay was used to measure cell proliferation in transfected cells. The transwell assay was used to detect the relative invasion rate of transfected cells. The putative binding sites between SNHG20 and miR-217 were predicted by software LncBase v.2, and the interaction between SNHG20 and miR-217 was confirmed by dual-luciferase reporter assays and RIP assay. The rescue experiments were used to illustrate potential mechanisms.

Results

SNHG20 was upregulated in ovarian cancer tissues and cell lines. Overexpression of SNHG20 promoted ovarian cancer cell proliferation and invasion. MiR-217 was downregulated in ovarian cancer tissues and cells, and was negatively regulated by SNHG20. Moreover, miR-217 overexpression inhibited ovarian cancer cell proliferation and invasion. Furthermore, miR-217 mimic reversed the inhibitory effect of SNHG20 overexpression on the biological behavior of ovarian cancer cells.

Conclusions

SNHG20 promoted cell proliferation and invasion by sponging miR-217 in ovarian cancer. These results suggested that SNHG20 and miR-217 might provide new targets for therapeutic application in ovarian cancer.
Circadian activity of the fat dormouse Glis glis measured with camera traps at bait stations
Authors: Randler Christoph , Kalb Nadine
Published: July 2021

Monitoring of small nocturnal and arboreal rodents is difficult and often conducted using indirect techniques. Here, we measured the circadian activity of the fat dormouse (Glis glis) directly using camera traps. The study took place at the Spitzberg in SW Germany. Data were collected using six Bushnell Natureview cameras with a macro lens at baited feeding stations. At 14 out of 41 active camera locations, edible dormice occurred. We collected 301 events between 8th July and 5th October 2018. There were 21.5 events per camera trap (SD 30.4), ranging from 1 to 82. The edible dormouse showed a nocturnal pattern, with a mean activity around midnight at 24:15 h. The pattern shows a slightly bimodal activity. Feeding activity started around or even slightly before sunset and stopped right before sunrise. The study shows that circadian activity, in this respect feeding activity, can be captured by camera trapping, which is a non-invasive method, and can be applied easily in the field.
Effect of linear and Mooney–Rivlin material model on carotid artery hemodynamics
Authors: Kumar Nitesh , Pai R. , Manjunath M. S. , Ganesha A. , Abdul Khader S. M.
Published: July 2021

Atherosclerosis is one of the most common cardiovascular diseases leading to high morbidity. The study of arterial dynamics using fluid–structure interaction (FSI) technique by taking into account the physiology of flow, the critical hemodynamic parameters can be determined which plays a crucial role in predictive medicine. Due to advances in the computational facilities, coupled field analysis such as FSI can facilitate understanding of the mechanics of stenosis progression and its early diagnosis. In this study a two-way FSI analysis is carried out using modified Navier–Stokes equations as the governing equations of blood flow for determining hemodynamic parameters. The arterial wall has been described at different linear elastic modulus and compared with hyperelastic Mooney–Rivlin model to evaluate the effect of different arterial stiffness on hemodynamics. The Mooney–Rivlin model predicts flow reduction with the severe backflow at arterial bifurcation resulting in decreased shear stress and oscillatory behavior. Furthermore, these findings may be used in understanding the advantages and disadvantages of using hyperelastic artery model in numerical simulations to better understand and predict the variable that causes cardiovascular diseases and as a diagnostic tool. In the present study, variation due to change in arterial wall properties such as linear elastic and Mooney Rivlin hyperelastic and its influence on hemodynamics are investigated.
16S rRNA gene amplicon sequencing of gut microbiota in gestational diabetes mellitus and their correlation with disease risk factors
Authors: Wei J. , Qing Y. , Zhou H. , Liu J. , Qi C. , Gao J.
Published: July 2021

Purpose

Although the gut microbiota (GM) are associated with various diseases, their role in gestational diabetes mellitus (GDM) remains uncharacterized. Further study is urgently needed to expose the real relationship between GM and GDM.

Methods

We performed a prospective study in 33 pregnant Chinese individuals [15, GDM; 18, normal glucose tolerance (NGT)] to observe the fecal microbiota by 16S rRNA gene amplicon sequencing at 24–28 weeks of gestational age after a standard 75 g oral glucose tolerance test. Linear regression analysis was employed to assess the relationships between the GM and GDM clinical parameters.

Results

Sequencing showed no difference in the microbiota alpha diversity but a significant difference in the beta diversity between the GDM and NGT groups, with the relative abundances of Ruminococcus bromii, Clostridium colinum, and Streptococcus infantis being higher in the GDM group (P < 0.05). The quantitative PCR results validated the putative bacterial markers of R. bromii and S. infantis. Moreover, a strong positive correlation was found between S. infantis and blood glucose levels after adjusting for body mass index (P < 0.05).

Conclusion

Three abnormally expressed intestinal bacteria (R. bromii, C. colinum, and S. infantis) were identified in GDM patients. S. infantis may confer an increased risk of GDM. Hence, the GM may serve as a potential therapeutic target for GDM.
Health Effects of Occupational Noise
Authors: Pretzsch Anna , Seidler Andreas , Hegewald Janice
Published: July 2021

Purpose of Review

Workplace noise negatively impacts health, and noise-induced hearing loss is the most common work-related disease in many countries. Occupational noise may also cause cardiovascular disease, and there is epidemiologic evidence on the non-auditory effects of noise. This paper aims to briefly present and summarize the latest evidence on the auditory and non-auditory health effects of occupational noise exposure from the last 5 years.

Recent Findings

Two systematic reviews assessing the cardiovascular effects of occupational noise exposure were published in the last year. Our own recent review found convincing evidence of an association between occupational noise exposure > 80 dB(A) and hypertension and a dose-response relationship between noise exposure and hypertension risk. Another review of cardiovascular disease conducted by the World Health Organization (WHO) and the International Labour Organization (ILO) found an increased risk of incident ischemic heart disease at noise exposures ≥ 85 dB(A). Recent reviews on work-related injuries, diabetes, acoustic neuroma, and pregnancy outcomes also find noise-related associations.

Evidence of an association between occupational noise and cardiovascular outcomes was recently evaluated. We found the risk of hypertension increases with a clear dose-response relationship at noise levels > 80 dB(A). The WHO/ILO review highlights the lack of quality research including women. Additional high-quality research on epigenetic effects, oxidative stress, work-related injuries, diabetes, acoustic neuroma, and pregnancy outcomes is also needed. Urgently needed (increased) measures of workplace noise reduction will reduce the incidence of noise-induced hearing loss and help prevent cardiovascular diseases, especially hypertension.