bluuebunny/crossref_metadata_2025 huggingface dataset:
The Prevalence and Lived Experience of Pain in People Undertaking Dialysis
Authors: Moore Ivy , Byrne Pauline , Ilic Narelle , Chen Jenny Heng-Chen , Lambert Kelly
Published: January 2023

(1) Background: Pain is a prevalent and debilitating symptom associated with kidney failure. However, the impact of pain on quality of life remains unclear. We aimed to identify the prevalence, severity and characteristics of people undertaking dialysis impacted by pain and explore the lived experience of pain (2) Methods: A cross-sectional survey was administered to people undertaking haemodialysis or via telephone to those undertaking peritoneal and home haemodialysis in a single tertiary centre. Open-ended questions were analysed using thematic analysis. (3) Results: Responses were received from 131 participants (response rate 66.8%). Most were undergoing haemodialysis (87.0%). Pain was present in 92% (n = 121) of patients with 62% (n = 81) reporting pain as severe to excruciating. Common sites of pain were joints, muscle cramps, headaches, fistula pain, non-specific back pain and neuropathy. The overarching theme from the thematic analysis was that pain was a “debilitating and accepted burden” (4) Conclusions: Pain is highly prevalent, severe and debilitating in those on dialysis. There is a need for health care providers to be proactive and attentive to the management of pain. More research is needed to identify effective treatment approaches to decrease pain burden and improve the quality of life in those with kidney failure.
Plant Community, Soil and Microclimate Attributes after 70 Years of Natural Recovery of an Abandoned Limestone Quarry
Authors: Stephan Kirsten , Hubbart Jason A.
Published: January 2023

With globally more than 100,000 km2 impacted by surface mining at present, and with increasing demand for surface-mined products, land managers are challenged to address landscape degradation of decommissioned quarries, especially in urban areas. In this study, soil, microclimate, and vegetation community data were collected from geomorphologically distinct locations (quarry floor, platform with pond, quarry top, highwall edge) within an urban limestone quarry abandoned 70 years ago without reclamation in central Missouri, USA. Results were compared with two nearby reference sites to bookend conditions in the abandoned quarry, including a recently closed quarry and an urban forest. Results of this study showed that abiotic mining legacies gave rise to distinct vegetation communities comprising 74 native species but also 21 non-native species. Species richness was increased near persistent edges (cliff edge, pond edge) and approached the lower range of species richness found in natural areas in the region. The results of this case study are congruent with the growing body of studies about spontaneous succession on abandoned surface mines worldwide in that spontaneous (vs. managed) revegetation can lead to species-rich, near-natural communities. This finding may justify revision of current legislation requiring technical reclamation of surface mines, especially where favorable substrate, such as limestone, is conducive to swift onset of revegetation. To improve the ecological value of such areas, the provision of funding for long-term invasive species management should also be considered.
“Inspiring” Policy Transfer: Analysis of Urban Renewal in Four First-Tier Chinese Cities
Authors: Huang Yuanyuan , Wei Lizhen , Liu Guiwen , Cui Wenjing , Xie Fangyun , Deng Xun
Published: January 2023

Most Chinese cities have spent decades achieving urbanisation. So far, rural urbanisation has shifted to urban renewal. However, the distinction between a rapidly changing social environment and the establishment of an institution has led to the failure of urban renewal policies to sustainably achieve complete transformation through urban modernisation involving many stakeholders. Owing to the top-down political system in China, the formulation and implementation of urban renewal policies are carried out in a closed-loop process in which “decisions are issued by the central government to the local government which gives feedback to the centre”. This seems to affect urban renewal through a transfer of renewal policies in a local area. Therefore, it is essential to explore the differences between the urban renewal policies at different government levels and to analyse these policies in diverse urban contexts with multiple stakeholders. Based on the policy transfer theory, this paper selects 216 core policy texts at the state level and at the level of four first-tier cities (Beijing, Shanghai, Guangzhou, and Shenzhen), and uses the methods of text mining and semantic analysis to form open coding, axial coding, and selective coding. Furthermore, it discusses the policy transfer and impact mechanism of urban renewal policy at different levels with diverse characteristics of policy subsystems. We found that the transfer of urban renewal policy occurred in China through top-down coercive vertical transfer, bottom-up combination reverse transfer, and voluntary horizontal transfer among cities. Finally, we suggest that “inspiration”-type policy transfer is an effective method to promote urban renewal in China.
Kastoria and Mikri Prespa Lakes: The Impact of Anthropogenic Activities on the Differentiation in the Genotoxic and Toxic Profile of the Surface Water
Authors: Efthimiou Ioanna , Vlastos Dimitris , Triantafyllidis Vassilios , Antonopoulou Maria
Published: January 2023

Urban–industrial and agricultural waste can add significant amounts of pollutants to surface water. Therefore, the surface water from Mikri Prespa and Kastoria lakes was assessed for its toxic, genotoxic, and cytotoxic effects. Water samples were collected during the spring of two different years (S1 and S2) in order to investigate the anthropogenic effects on both lakes. Physicochemical parameters were identified, while significant elements were determined via ICP-MS/MS. The in vitro cytokinesis-block micronucleus (CBMN) assay in cultured human lymphocytes and the Aliivibrio fischeri bioassay were applied to evaluate the genotoxic–cytotoxic and toxic effects, respectively. In the CBMN assay, significant differences were observed in genotoxic and cytotoxic indices between the different time periods. Decreased indices in S2 could be correlated with a potential diminution in the negative human effect on the environment along the lakes. In the Aliivibrio fischeri bioassay, no significant difference in the toxicity of the surface water samples from Mikri Prespa was observed, whereas significant differences were identified in the samples from Lake Kastoria. The differences in toxic, genotoxic, and cytotoxic effects reveal the impact and the influence of anthropogenic activities in the areas of land around the lakes in relation to their surface water quality.
Carbonate Mineral Dissolution and Its Carbon Sink Effect in Chinese Loess
Authors: Shao Mingyu , Adnan Muhammad , Zhang Liankai , Liu Pengyu , Cao Jianhua , Qin Xiaoqun
Published: January 2023

The relationship between the source and sink of atmospheric CO2 has always been a widely discussed issue in global climate change research. Recent studies revealed that the chemical weathering of carbonate rocks contributed to 1/3 (~0.5 Pg C/yr) of the missing carbon sinks (MCS) globally, and there are still 2/3 of MCS (~0.5 Pg C/yr) that need to be explored. As one of the main overburdened parts of the earth, loess is one of the important driving factors for atmospheric CO2 consumption. Here, we elaborated on the dissolution process and the carbon sink effect from carbonate and silicate minerals in loess. The relationship between carbonate dissolution and carbon source/sink is elucidated, and the mechanism of carbon sink formation from secondary carbonates in loess is clarified. Additionally, the commonly used methods for the identification of primary and secondary carbonates are summarized, and the methods for the study of loess carbon sinks and the influencing factors of loess carbon sinks are also revealed. Based on the research results and progress interpretations, the prospects of loess carbon sinks are discussed to provide a scientific basis for further research on loess carbon sinks.
Uncovering Network Heterogeneity of China’s Three Major Urban Agglomerations from Hybrid Space Perspective-Based on TikTok Check-In Records
Authors: Xiang Bowen , Chen Rushuang , Xu Gaofeng
Published: January 2023

Urban agglomeration is an essential spatial support for the urbanization strategies of emerging economies, including China, especially in the era of mediatization. From a hybrid space perspective, this paper invites TikTok cross-city check-in records to empirically investigate the vertical and flattened distribution characteristics of check-in networks of China’s three major urban agglomerations by the hierarchical property, community scale, and node centrality. The result shows that (1) average check-in flow in the Yangtze River Delta, Beijing-Tianjin-Hebei, and Pearl River Delta network decreases in descending order, forming a Z-shaped, single-point radial, and N-shaped structure, respectively. (2) All three urban agglomerations exhibit a nexus community structure with the regional high-flow cities as the core and the surrounding cities as the coordinator. (3) Geographically proximate or recreation-resource cities have a high degree of hybrid spatial accessibility, highlighting their nexus role. Finally, the article further discusses the flattened evolutionary structure of the check-in network and proposes policy recommendations for optimizing check-in networks at both the digital and geospatial levels. The study gains from the lack of network relationship perspective in the study of location-based social media and provides a novel research method and theoretical support for urban agglomeration integration in the context of urban mediatization.
Identifying Critical Thresholds in the Impacts of Invasive Alien Plants and Dune Paths on Native Coastal Dune Vegetation
Authors: de Francesco Maria Carla , Tozzi Francesco Pio , Buffa Gabriella , Fantinato Edy , Innangi Michele , Stanisci Angela
Published: January 2023

Invasive alien plants (IAP) pose a major threat to biodiversity and have a negative impact on the integrity and conservation status of plant communities. Mediterranean dunes are widely exposed to IAP, due to their environmental heterogeneity and the anthropogenic pressures to which they are subjected. The current study explored the possible existence of critical thresholds of IAP cover/abundance and dune path impacts that may cause the decline in diagnostic species cover in shifting and transition dunes. A random sampling of 126 plots in areas invaded and not invaded by IAP across the Italian Adriatic dunes has been used and the recorded species have been classified in ecological guilds. In order to explore the effect of plant community composition and distances from dune paths on the diagnostic species cover, a Random Forest regression model has been fitted. The results revealed that three main critical thresholds can be detected concerning IAP total cover, IAP Oenothera stucchii Soldano abundance and the distance from dune paths and they work differently in shifting and transition dunes. The identification of such cut-off points provides useful insights for an array of actions to preserve the biodiversity of the Mediterranean coastal dunes.
Trade-Offs, Adaptation and Adaptive Governance of Urban Regeneration in Guangzhou, China (2009–2019)
Authors: Li Bin , Yang Kaihan , Axenov Konstantin E. , Zhou Long , Liu Huiming
Published: January 2023

This paper explores the specific “authoritarian” type of adaptive governance of urban regeneration using the example of Guangzhou city as the frontier of China’s reforms. As opposed to the “democratic” type of adaptive governance with its bottom-up policy initiations, community autonomy, polycentric power, participation in decision making, and self-organized policy actors, adaptive governance in Guangzhou is based on top-down decision making and implementation of public authorities’ solutions with the high role of political considerations. By analyzing data collected from policy documents, interviews, secondary data, and participative observations, this paper reveals three phases of urban regeneration in Guangzhou between 2009 and 2019: two of them based on “Three Old Redevelopment” policy implementation and the third one based on the local micro-regeneration initiative. Tradeoffs among urban regeneration, land leasing income and micro-regeneration are the key means of policy adaptation which differ from the described phases. Methodologically, the paper does not limit itself by answering only the traditional research questions in regeneration studies of “what” has changed and “why” these changes have happened. Instead, the main focus includes “how” such changes have occurred, which is less researched in the literature. Social–political mechanisms, including limited check-and-balance, selective feedback, and the social learning capacity of the local state, are crucial governance factors to enable adaptation.
Assessing and Mapping Spatial Variation Characteristics of Natural Hazards in Pakistan
Authors: Hussain Muhammad Awais , Zhang Shuai , Muneer Muhammad , Moawwez Muhammad Aamir , Kamran Muhammad , Ahmed Ejaz
Published: January 2023

One nation with the highest risk of climate catastrophes is Pakistan. Pakistan’s geographical nature makes it susceptible to natural hazards. Pakistan is facing regional differences in terms of climate change. The frequency and intensity of natural hazards due to climate change vary from place to place. There is an urgent need to recognize the spatial variations in natural hazards inside the country. To address such problems, it might be useful to map out the areas that need resources to increase resilience and accomplish adaptability. Therefore, the main goal of this research was to create a district-level map that illustrates the multi-hazard zones of various regions in Pakistan. In order to comprehend the geographical differences in climate change and natural hazards across Pakistan, this study examines the relevant literature and data currently available regarding the occurrence of natural hazards in the past. Firstly, a district-level comprehensive database of Pakistan’s five natural hazards (floods, droughts, earthquakes, heatwaves, and landslides) was created. Through consultation with specialists in related areas, hazard and weighting factors for a specific hazard were specified based on the structured district-level historical disaster database of Pakistan. After that, individual and multi-hazard ratings were computed for each district. Then, using estimated multi-hazard scores, the districts of Pakistan were classified into four zones. Finally, a map of Pakistan’s multi-hazard zones was created per district. The study results are essential and significant for policymakers to consider when making decisions on disaster management techniques, that is, when organizing disaster preparedness, mitigation, and prevention plans.
Smallholders Are Not the Same: Under the Hood of Kosovo Agriculture
Authors: Kostov Philip , Davidova Sophia
Published: January 2023

Economists and policy makers are interested in producers’ responses to policies in order to achieve some national or sectoral objectives, e.g., growth, employment, food security. The way producers respond to policy depends on their production function. If producers do not have homogenous production function, policy responses will be heterogeneous. We use the underlying functional relationship to derive homogenous groupings. The paper employs finite regression mixture models to specify and estimate farm groups with regard to pre-specified functional relationship. The proposed approach is illustrated with regard to the aggregate production function of Kosovo agriculture, characterised by high prevalence of small farmers. The results point out to two farm clusters. The first one extracts more output from labour and intermediate consumption. The second one makes a better use of land. Perhaps, surprisingly, both clusters appear quite similar in terms of their stock of production inputs. Cluster 1 however appears to be more specialised. We can conclude that in Kosovo agriculture appearances and size are not primary determinants of productivity.
Estimation of Runoff and Sediment Yield in Response to Temporal Land Cover Change in Kentucky, USA
Authors: Kandel Smriti , Gyawali Buddhi , Shrestha Sandesh , Zourarakis Demetrio , Antonious George , Gebremedhin Maheteme , Pokhrel Bijay
Published: January 2023

Land cover change is prevalent in the eastern Kentucky Appalachian region, mainly due to increased surface mining activities. This study explored the potential change in land cover and its relationship with stream discharge and sediment yield in a watershed of the Cumberland River near Harlan, Kentucky, between 2001 and 2016, using the Soil and Water Assessment Tool (SWAT). Two land cover scenarios for the years 2001 and 2016 were used separately to simulate the surface runoff and sediment yield at the outlet of the Cumberland River near Harlan. Land cover datasets from the National Land Cover Database (NLCD) were used to reclassify the land cover type into the following classes: water, developed, forest, barren, shrubland, and pasture/grassland. Evaluation of the relationship between the land cover change on discharge and sediment was performed by comparing the average annual basin values of streamflow and sediment from each of the land cover scenarios. The SWAT model output was evaluated based on several statistical parameters, including the Nash–Sutcliffe efficiency coefficient (NSE), RMSE-observations standard deviation ratio (RSR), percent bias (PBIAS), and the coefficient of determination (R²). Moreover, P-factor and R-factor indices were used to measure prediction uncertainty. The model showed an acceptable range of agreement for both calibration and validation between observed and simulated values. The temporal land cover change showed a decrease in forest area by 2.42% and an increase in developed, barren, shrubland, and grassland by 0.11%, 0.34%, 0.53%, and 1.44%, respectively. The discharge increased from 92.34 mm/year to 104.7 mm/year, and sediment increased from 0.83 t/ha to 1.63 t/ha from 2001 to 2016, respectively. Based on results from the model, this study concluded that the conversion of forest land into other land types could contribute to increased surface runoff and sediment transport detached from the soil along with runoff water. The research provides a robust approach to evaluating the effect of temporal land cover change on Appalachian streams and rivers. Such information can be useful for designing land management practices to conserve water and control soil erosion in the Appalachian region of eastern Kentucky.
Land Use and Land Cover Change Monitoring and Prediction of a UNESCO World Heritage Site: Kaziranga Eco-Sensitive Zone Using Cellular Automata-Markov Model
Authors: Nath Nityaranjan , Sahariah Dhrubajyoti , Meraj Gowhar , Debnath Jatan , Kumar Pankaj , Lahon Durlov , Chand Kesar , Farooq Majid , Chandan Pankaj , Singh Suraj Kumar , Kanga Shruti
Published: January 2023

The Kaziranga Eco-Sensitive Zone is located on the edge of the Eastern Himalayan biodiversity hotspot region. In 1985, the Kaziranga National Park (KNP) was declared a World Heritage Site by UNESCO. Nowadays, anthropogenic interference has created a significant negative impact on this national park. As a result, the area under natural habitat is gradually decreasing. The current study attempted to analyze the land use land cover (LULC) change in the Kaziranga Eco-Sensitive Zone using remote sensing data with CA-Markov models. Satellite remote sensing and the geographic information system (GIS) are widely used for monitoring, mapping, and change detection of LULC change dynamics. The changing rate was assessed using thirty years (1990–2020) of Landsat data. The study analyses the significant change in LULC, with the decrease in the waterbody, grassland and agricultural land, and the increase of sand or dry river beds, forest, and built-up areas. Between 1990 and 2020, waterbody, grassland, and agricultural land decreased by 18.4, 9.96, and 64.88%, respectively, while sand or dry river beds, forest, and built-up areas increased by 103.72, 6.96, and 89.03%, respectively. The result shows that the area covered with waterbodies, grassland, and agricultural land is mostly converted into built-up areas and sand or dry river bed areas. According to this study, by 2050, waterbodies, sand or dry river beds, and forests will decrease by 3.67, 3.91, and 7.11%, respectively; while grassland and agriculture will increase by up to 16.67% and 0.37%, respectively. The built-up areas are expected to slightly decrease during this period (up to 2.4%). The outcome of this study is expected to be useful for the long-term management of the Kaziranga Eco-Sensitive Zone.
Conventional Implicatures in Argumentation
Authors: Hautli-Janisz Annette , Budzynska Katarzyna , Reed Chris
Published: January 2023

Despite the ubiquity of conventional implicatures in language and the critical role they play in argumentation, they have heretofore been almost entirely absent from theories of argument and the linguistic expression of reasoning. In this paper, we discuss conventional implicatures (cis) as an interesting phenomenon at the interface of semantics, pragmatics and argumentation by harnessing research in semantics and pragmatics and extending an existing account for argument diagramming with this type of implicit meaning. In particular, we show that cis are unlike enthymemes, which are extremely challenging to conceptualise and to specify precisely. Instead, cis are anchored on the linguistic surface, trigger a largely predictable discourse contribution and are therefore more apt for argument analysis. By surfacing conventionally implicated material, we can unpack a wider variety of ways in which arguments are triggered by, composed of, and demolished by implicit discourse material, in particular inferential structures, conflicts and references to ethos. This also allows us to model the complex interplay between conventional implicature and argumentation, which in turn sheds new light on the interplay of meaning and argumentation in general.
Epistemic Stance in Chinese L2 Spoken English: The Effect of Grade and Genre-Specific Questions
Authors: Xu Fang , Cao Rongping
Published: January 2023

Zuczkowski et al.’s KUB model clarified three epistemic stances: Knowing/Certain, Not Knowing Whether and Believing/Uncertain, and Unknowing/Neither Certain nor Uncertain, according to the speakers’ communicated information, and delineated three types of markers: macro-markers, micro-markers, and morphosyntactic markers. The model has seldom been applied to L2 instruction. To address this gap, the study examines the effect of grade and genre-specific questions on Chinese L2 speakers’ choice of epistemic markers with reference to the model by analyzing the self-built corpus consisting of the oral data collected from two groups: Group One consisting of 20 sophomores and Group Two comprising 20 first-year graduate students. The participants were required to answer four genre-specific questions covering argumentation, description, narration, and exposition. The results show that the two group members use similar epistemic markers (EMs) for the Knowing/Certain and Not Knowing Whether and Believing /Uncertain positions but present a slight discrepancy in Unknowing/Neither Certain nor Uncertain stance-taking. The genre-based questions demonstrate a significant effect on the graduate speakers’ use of the micro-markers and morphosyntactic markers for the Not Knowing Whether and Believing/Uncertain and the macro-markers and morphosyntactic markers for the Unknowing/Neither Certain nor Uncertain. It indicates that high-grade speakers are more sensitive to genre-based messages, though they use rather limited epistemic forms as low-grade speakers do. The findings suggest that English as a Second Language (ESL) oral instruction in China should be reformed and supplemented with diverse EMs to allow the speakers to take the epistemic stance they are comfortable with.
Mitigating the Risk of Autonomous Weapon Misuse by Insurgent Groups
Authors: Kwik Jonathan
Published: January 2023

The intersection between autonomous weapon systems (‘AWS’) and non-State armed groups (‘NSAG’) is an underexplored aspect of the AWS debate. This article explores the main ways future policymakers can reduce the risk of NSAGs committing violations of the laws of armed conflict (‘LOAC’) using AWS once the technology becomes more prolific and easily distributable. It does this by sketching a chronological picture of an NSAG’s weapons obtention process, looking first at its likely suppliers and transport routes (acquisition), and, subsequently, at factors which can increase the risk of LOAC violations once the system is in their possession (use). With regard to use, we find that the lack of explicit legal obligations in LOAC to (a) review weapons meant solely for transfer and (b) provide technical training to recipients of transfer constitute serious reasons why LOAC violations may be aggravated with the introduction of AWS to insurgent groups. We also find, however, that States are uniquely and powerfully placed to address both acquisition and use factors, and outline how they can be persuaded into implementing the risk-reducing measures recommended in this article for purely strategic reasons, i.e., even if they express no interest in improving LOAC compliance per se.
Primary and Secondary Physiological Stress Responses of European Sea Bass (Dicentrarchus labrax) Due to Rearing Practices under Aquaculture Farming Conditions in M’diq Bay, Moroccan Mediterranean: The Case of Sampling Operation for Size and Weight Measurement
Authors: Cheyadmi Soumaya , Chadli Housni , Nhhala Hassan , El Yamlahi Bouchra , El Maadoudi Mohammed , Kounnoun Ayoub , Cacciola Francesco , Ez-Zaaim Ayoub , Chairi Hicham
Published: January 2023

Globally, aquaculture contributes to sustainable food and nutritional stability. However, stress conditions constitute a major threat affecting farmed-fish welfare and fish farms’ performances. In this regard, the present study was aimed at measuring and comparing in-situ (offshore) the physiological stress responses caused by recurrent sampling operations for length–weight measurement. Studied fish were European sea bass Dicentrarchus labrax sub-adults and adults reared in intensive farming conditions in M’diq Bay, on the Moroccan Mediterranean coast. The physiological stress response was evaluated by measuring blood biomarkers, including cortisol, glucose, lactate, total cholesterol and total proteins levels, and hematocrit percentage. The hypercortisolemia, hyperglycemia, hyperlactatemia and hypoproteinemia detected in the post-sampling state in both age groups of D. labrax indicated stress tendencies and a high sensitivity to aquaculture practice-related stress factors, with major and minor responses detected in the same age and same stress conditions. It is also interesting to note that the fish age and the time-course of the sampling operation had a statistically significant effect in terms of the physiological response (with p < 0.01 and p < 0.001, respectively). In conclusion, the present study showed that sea bass subjected to various stressful situations in intensive farming conditions displayed a physiological stress response specific to its age, to the individual status, as well as to the duration of stressor.
The Formation of RNA Pre-Polymers in the Presence of Different Prebiotic Mineral Surfaces Studied by Molecular Dynamics Simulations
Authors: Dujardin Alix , Himbert Sebastian , Pudritz Ralph , Rheinstädter Maikel C.
Published: January 2023

We used all-atom Molecular Dynamics (MD) computer simulations to study the formation of pre-polymers between the four nucleotides in RNA (AMP, UMP, CMP, GMP) in the presence of different substrates that could have been present in a prebiotic environment. Pre-polymers are C3′–C5′ hydrogen-bonded nucleotides that have been suggested to be the precursors of phosphodiester-bonded RNA polymers. We simulated wet–dry cycles by successively removing water molecules from the simulations, from ~60 to 3 water molecules per nucleotide. The nine substrates in this study include three clay minerals, one mica, one phosphate mineral, one silica, and two metal oxides. The substrates differ in their surface charge and ability to form hydrogen bonds with the nucleotides. From the MD simulations, we quantify the interactions between different nucleotides, and between nucleotides and substrates. For comparison, we included graphite as an inert substrate, which is not charged and cannot form hydrogen bonds. We also simulated the dehydration of a nucleotide-only system, which mimics the drying of small droplets. The number of hydrogen bonds between nucleotides and nucleotides and substrates was found to increase significantly when water molecules were removed from the systems. The largest number of C3′–C5′ hydrogen bonds between nucleotides occurred in the graphite and nucleotide-only systems. While the surface of the substrates led to an organization and periodic arrangement of the nucleotides, none of the substrates was found to be a catalyst for pre-polymer formation, neither at full hydration, nor when dehydrated. While confinement and dehydration seem to be the main drivers for hydrogen bond formation, substrate interactions reduced the interactions between nucleotides in all cases. Our findings suggest that small supersaturated water droplets that could have been produced by geysers or springs on the primitive Earth may play an important role in non-enzymatic RNA polymerization.
Malignant Pleural Effusions: Updates in Diagnosis and Management
Authors: Hughes Stephen M. , Carmichael Jacob Jonas
Published: January 2023

Malignant pleural effusions remain a significant clinical problem resulting in greater than 125,000 hospitalizations per year and leading to over 5 billion dollars in healthcare utilization costs. Not only are health care expenditures related to malignant pleural effusion significant, but malignant pleural effusions also often result in significant patient discomfort and distress, largely at the end of life. Advances in management over the past several years have provided patients with greater autonomy as they are able to provide self-aid at home either alone or with family assistance. Additionally, practice changes have allowed for fewer interventions allowing patients to spend more time out of the clinic or inpatient wards.
Ust-Luga Seaport of Russia: Biological Invasions and Resting Stages Accumulation
Authors: Alekseev Victor , Sukhikh Natalia
Published: January 2023

This article describes the results of a three-year study of invasive species of aquatic ecosystems in the vicinity of Ust-Luga, the largest Russian seaport in the Baltic. Taking into account the great importance of the participation of marine vessels in the dispersal of invasive species, an experimental study of the seasonality of accumulation of resting stages of aquatic invertebrates in the ballast compartments of a vessel located in the Baltic Sea of the Gulf of Finland was carried out. Experiments show that the time of filling the ballast compartments in late summer and autumn poses the greatest risk for the spread of aquatic invertebrates with ship ballast water. In the Baltic Russian port, 11 invasive species of zooplankton and zoobenthos were found, which comprises 15% of the biodiversity in the samples. Copepoda demonstrated the highest presence of invasive species in class among zooplankton groups (14%) and Malacostraca among benthos groups (80%). Alien species findings correspond to the main vectors of invasive species dispersal for the Baltic Sea: North America, Indochina, and the Ponto-Caspian region.
A Voxel-Based Morphometric Study of Gray Matter in Specific Phobia
Authors: Rivero Francisco , Marrero Rosario J. , Olivares Teresa , Peñate Wenceslao , Álvarez-Pérez Yolanda , Bethencourt Juan Manuel , Fumero Ascensión
Published: January 2023

The objective of this study was to analyze the neurostructural abnormalities of brain areas responsible for the acquisition and maintenance of fear in small animal phobia by comparing gray matter volume (GMV) in individuals with phobia and non-fearful controls. Structural magnetic resonance imaging was obtained from 62 adults (79% female) assigned to one of two groups: 31 were diagnosed with small animal phobia and 31 were non-fearful controls. To investigate structural alterations, a whole-brain voxel-based morphometry analysis was conducted to compare the GMV of the brain areas involved in fear between both groups. The results indicated that individuals with a small animal specific phobia showed smaller GMV in cortical regions, such as the orbitofrontal (OFC) and medial frontal cortex, and greater GMV in the putamen than non-fearful controls. These brain areas are responsible for avoidant behavior (putamen) and emotional regulation processes or inhibitory control (prefrontal cortex (PFC)), which might suggest a greater vulnerability of phobic individuals to acquiring non-adaptive conditioned responses and emotional dysregulation. The findings provide preliminary support for the involvement of structural deficits in OFC and medial frontal cortex in phobia, contributing to clarify the neurobiological substrates for phobias.
Infectious Risks Related to Umbilical Venous Catheter Dwell Time and Its Replacement in Newborns: A Narrative Review of Current Evidence
Authors: Corso Lucia , Buttera Martina , Candia Francesco , Sforza Francesca , Rossi Katia , Lugli Licia , Miselli Francesca , Bedetti Luca , Baraldi Cecilia , Lucaccioni Laura , Iughetti Lorenzo , Berardi Alberto
Published: January 2023

The use of umbilical venous catheters (UVCs) has become the standard of care in the neonatal intensive care unit (NICU) to administer fluids, medications and parenteral nutrition. However, it is well known that UVCs can lead to some serious complications, both mechanical and infective, including CLABSI (Central Line-Associated Bloodstream Infections). Most authors recommend removing UVC within a maximum of 14 days from its placement. However, the last Infusion Therapy Standards of Practice (INS) guidelines recommends limiting the UVC dwell time to 7 to 10 days, to reduce risks of infectious and thrombotic complications. These guidelines also suggest as an infection prevention strategy to remove UVC after 4 days, followed by the insertion of a PICC if a central line is still needed. Nevertheless, the maximum UVC dwell time to reduce the risk of CLABSI is still controversial, as well as the time of its replacement with a PICC. In this study we reviewed a total of 177 articles, found by using the PubMed database with the following search strings: “UVC AND neonates”, “(neonate* OR newborn*) AND (UVC OR central catheter*) AND (infection*)”. We also analyze the INS guidelines to provide the reader an updated overview on this topic. The purpose of this review is to give updated information on CVCs infectious risks by examining the literature in this field. These data could help clinicians in deciding the best time to remove or to replace the UVC with a PICC, to reduce CLABSIs risk. Despite the lack of strong evidence, the risk of CLABSI seems to be minimized when UVC is removed/replaced within 7 days from insertion and this indication is emerging from more recent and larger studies.
Fully Automatic Left Ventricle Segmentation Using Bilateral Lightweight Deep Neural Network
Authors: Shoaib Muhammad Ali , Chuah Joon Huang , Ali Raza , Dhanalakshmi Samiappan , Hum Yan Chai , Khalil Azira , Lai Khin Wee
Published: January 2023

The segmentation of the left ventricle (LV) is one of the fundamental procedures that must be performed to obtain quantitative measures of the heart, such as its volume, area, and ejection fraction. In clinical practice, the delineation of LV is still often conducted semi-automatically, leaving it open to operator subjectivity. The automatic LV segmentation from echocardiography images is a challenging task due to poorly defined boundaries and operator dependency. Recent research has demonstrated that deep learning has the capability to employ the segmentation process automatically. However, the well-known state-of-the-art segmentation models still lack in terms of accuracy and speed. This study aims to develop a single-stage lightweight segmentation model that precisely and rapidly segments the LV from 2D echocardiography images. In this research, a backbone network is used to acquire both low-level and high-level features. Two parallel blocks, known as the spatial feature unit and the channel feature unit, are employed for the enhancement and improvement of these features. The refined features are merged by an integrated unit to segment the LV. The performance of the model and the time taken to segment the LV are compared to other established segmentation models, DeepLab, FCN, and Mask RCNN. The model achieved the highest values of the dice similarity index (0.9446), intersection over union (0.8445), and accuracy (0.9742). The evaluation metrics and processing time demonstrate that the proposed model not only provides superior quantitative results but also trains and segments the LV in less time, indicating its improved performance over competing segmentation models.
Berberine—A Promising Therapeutic Approach to Polycystic Ovary Syndrome in Infertile/Pregnant Women
Authors: Ionescu Oana-Maria , Frincu Francesca , Mehedintu Andra , Plotogea Mihaela , Cirstoiu Monica , Petca Aida , Varlas Valentin , Mehedintu Claudia
Published: January 2023

Polycystic ovary syndrome (PCOS) is a disorder with an unknown etiology that features a wide range of endocrine and metabolic abnormalities that hamper fertility. PCOS women experience difficulties getting pregnant, and if pregnant, they are prone to miscarriage, gestational diabetes, pregnancy-induced hypertension and preeclampsia, high fetal morbidity, and perinatal mortality. Insulin, the pancreatic hormone best known for its important role in glucose metabolism, has an underrated position in reproduction. PCOS women who have associated insulin resistance (with consequent hyperinsulinemia) have fertility issues and adverse pregnancy outcomes. Lowering the endogen insulin levels and insulin resistance appears to be a target to improve fertility and pregnancy outcomes in those women. Berberine is an alkaloid with a high concentration in various medicinal herbs that exhibits a hypoglycaemic effect alongside a broad range of other therapeutic activities. Its medical benefits may stand up for treating different conditions, including diabetes mellitus. So far, a small number of pharmacological/clinical trials available in the English language draw attention towards the good results of berberine’s use in PCOS women with insulin resistance for improving fertility and pregnancy outcomes. Our study aims to uncover how berberine can counteract the negative effect of insulin resistance in PCOS women and improve fertility and pregnancy outcomes.
Analysis of Influencing Factors of Cementitious Material Properties of Lead–Zinc Tailings Based on Orthogonal Tests
Authors: Yin Ziyi , Li Rui , Lin Hang , Chen Yifan , Wang Yixian , Zhao Yanlin
Published: January 2023

At present, the treatment of tailings is mostly carried out in the form of stacking in tailings ponds, resulting in a huge waste of mineral resources and a major threat to the environment and ecology. Using tailings instead of a part of the cement to make cementitious materials is an effective way to reduce the accumulation of tailings. In this paper, lead–zinc tailings-based cementitious materials were prepared by using lead–zinc tailings, fly ash, and ordinary Portland cement, and the effects of four factors on the mechanical properties of lead–zinc tailings, as well as fly ash content, cement content, and water–binder ratio were studied by orthogonal experiments. The corresponding relationship between the factors and the properties of cementitious materials was determined, and the optimization and prediction of the raw material ratio of lead–zinc tailings-based cementitious materials were realized. The test showed the ratio of raw materials to be at the lowest price ratio. Synchronously the ratio that meets the minimum strength requirements was predicted. When the proportion of fly ash:lead and zinc tailings:cement = 30:40:30 and the water–binder ratio was 0.4, the predicted compressive strength of the prepared cementitious material achieved 22.281 MPa, which meets the strength requirements, while the total content of lead–zinc tailings and fly ash was the highest at this time.
The Numerical Fatigue Life Analysis of a Conformal HPDC Mould Core Additively Manufactured from Maraging Steel
Authors: Piekło Jarosław , Garbacz-Klempka Aldona , Burbelko Andriy
Published: January 2023

This paper presents the results of a stress analysis and fatigue life calculation of an HPDC mould core. The calculations were performed using Abaqus and fe-safe software. The numerical model of a core cooled by a conformal channel was based on an existing and working counterpart made of additively manufactured high-strength 1.2709 maraging steel. This study shows that the conformal channel results in a lower average core temperature as compared to the temperature of the same core shape cooled by the conventional method. The course of the stress changes during the mould cycle was also determined. It was found that stresses on the core surface caused the cyclic compression and tension of the material. The necessary strength tests of 1.2709 steel produced by selective laser melting (SLM) within a temperature range of 25 to 550 °C, which were necessary to define the fatigue coefficients by the Seeger approximation method, were also carried out in this study, along with metallographic tests of the fractures of the specimens. Based on the multiaxial fatigue criterion and using the maximum principal deformation hypothesis, the fatigue life of the core and channel surfaces was determined. Based on the calculations, it was shown that crack initiation on the channel surface can occur earlier than on the outer surface of the core.
Effect of Step Size on the Formability of Al/Cu Bimetallic Sheets in Single Point Incremental Sheet Forming
Authors: Żaba Krzysztof , Puchlerska Sandra , Kuczek Łukasz , Trzepieciński Tomasz , Maj Piotr
Published: January 2023

Single Point Incremental Forming (SPIF) is an unconventional forming process that is suitable for prototype production and small lot production due to the economical tooling cost, short lead time, and the ability to create symmetrical and asymmetrical complex geometries without the use of expensive dies. This article presents the effect of the step size Δz of a forming tool made of 145Cr6 tool steel on the formability and maximum forming angle, mechanical properties, hardness, surface roughness, microstructure and texture of bimetallic Al/Cu sheets. Experiments were conducted at a constant rotational speed and feed rate, with the use of rapeseed oil as a lubricant. The tests were carried out with the use of a forming tool on both sides of the bimetallic sheet. The shape and dimensions of the formed elements are determined by non-contact optical 3D scanning. It has been proved that an increase in the step size Δz affects the deterioration of the surface quality of the specimens (an increase in the Ra parameter from 0.2 μm to approximately 3 μm for the step size of 1.2 mm), while a small step size down Δz favours the geometric stability of the samples. With increasing step size (at Δx = Δy = const.), the drawpiece wall continually thinned until the material fractured. Based on the results, it was shown that increasing the step size Δz over 1.1 mm causes cracking of the drawpieces. Furthermore, greater thinning of the Al/Cu sheet was observed in the range of step size Δz between 0.7 and 1.0 mm for aluminum side and step size Δz ≤ 0.6 mm and Δz ≥ 1.1 mm for copper side. It was also found that the mechanical properties of the bimetal sheet decreased as a result of incremental forming. The greatest decrease in strength and ductility was recorded for a pitch of 1.2 mm. Strength decreased from 230 MPa (for sheet in initial state) to approximately 80 MPa, elongation from 12% to approximately 8.5%, and hardness from 120 HV10 for Cu and 60 HV10 for Al to approximately 30 HV10 for both layers.
Influence of Low- to Medium-Kaolinite Clay on the Durability of Limestone Calcined Clay Cement (LC3) Concrete
Authors: Ram Kiran , Flegar Matea , Serdar Marijana , Scrivener Karen
Published: January 2023

The kaolinite content is principally responsible for the durability performance of Limestone Calcined Clay Cement (LC3), which calls into question its global applicability. The clay supply has a significant impact on the LC3 system’s reduced carbon footprint advantage. The influence of kaolinite concentration from two separate clays (collected in East South-East Europe) on the durability performance of concrete was investigated in this study. The low-kaolinitic clay had 18% kaolinite, while the medium-kaolinitic clay contained around 41% kaolinite. The compressive strength, chloride intrusion, electrical conductivity, surface resistivity, and sorptivity index were measured on concrete after 28 days. Furthermore, the pore structure development of these mixtures was investigated in relation to the kaolinite content of the mixtures. The reactivity test was performed on clays to measure their reactivity levels within the cementitious system. The results show that kaolinite content has a moderate effect on compressive strength, but it has a considerable effect on other durability indices. When compared to the Portland cement mixture, the chloride migration and diffusion coefficients were reduced by 50% and 36%, respectively, in the combination with a medium kaolinite content (more than 40%). The low-kaolinitic clay, on the other hand, achieved 60% of the chloride penetration resistance of the medium-kaolinitic clay. Furthermore, low-kaolinitic clay has been demonstrated to be suitable for low-carbon concrete in moderate exposure conditions.
Degradation Processes of Medieval and Renaissance Glazed Ceramics
Authors: Kolářová Mária , Kloužková Alexandra , Kohoutková Martina , Kloužek Jaroslav , Dvořáková Pavla
Published: January 2023

Corrosion effects in deposit environments (soil, waste pit, etc.), together with the glaze adherence and fit, could cause severe deterioration accompanied by different types of defects or growth of corrosion products. The aim of this work was to identify the source of surface degradation of the lead-glazed ceramics sets from the Prague area from the Romanesque to the Renaissance period. A combination of X-ray fluorescence (XRF), X-ray diffraction (XRD), optical microscopy (OM), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDS), and simultaneous thermal analysis (STA) techniques along with stress state calculations was used to study the defects. Based on the interpretation of the possible sources of the observed defects, four types of degradation effects were schematically expressed for the archaeological samples. It was shown that the glazes were already appropriately chosen during the production of the Romanesque tiles and that their degradation occurred only due to long-term exposure to unsuitable environmental conditions.