bluuebunny/crossref_metadata_2025 huggingface dataset:
TP-FER: An Effective Three-phase Noise-tolerant Recognizer for Facial Expression Recognition
Authors: Li Junjie , Yuan Jin , Li Zhiyong
Published: November 2022

Single-label facial expression recognition (FER), which aims to classify single expression for facial images, usually suffers from the label noisy and incomplete problem, where manual annotations for partial training images exist wrong or incomplete labels, resulting in performance decline. Although prior work has attempted to leverage external sources or manual annotations to handle this problem, it usually requires extra costs. This article explores a simple yet effective three-phase paradigm (“warm-up,” “selection,” and “relabeling”) for FER task. First, the warm-up phase attempts to build an initial recognition network based on noisy samples for discriminative feature extractions and facial expression predictions. Then, the second selection phase defines several rules to choose high confident samples according to prediction scores, and the third relabeling phase assigns two potential labels to those samples for network updating according to a composite two-label loss. Compared with the previous studies, the three-phase learning could effectively correct noisy labels in the ground truth without extra information and automatically assign two potential labels to single-label samples without manual annotations. As a result, the label information is purified and supplemented with few cost, yielding significant performance improvement. Extensive experiments are conducted on three datasets, and the experimental results demonstrate that our approach is robust to noisy training samples and outperforms several state-of-the-art methods.
Progress in Multivariate Cryptography: Systematic Review, Challenges, and Research Directions
Authors: Dey Jayashree , Dutta Ratna
Published: November 2022

Multivariate Public Key Cryptosystem
(MPKC) seem to be promising toward future digital security even in the presence of quantum adversaries. MPKCs derive their security from the difficulty of solving a random system of multivariate polynomial equations over a finite field, which is known to be an NP-hard problem. This article aims at presenting a comprehensive survey that covers multivariate public key encryption and signature schemes specifically targeting toward security, efficiency, and parameter choice. The survey starts by giving an overview of the existing security challenges which include structural attacks such as
MinRank
attack,
differential attack
, and finding Gröbner basis for
direct attack
, and so on. Additionally, it discusses the necessary algorithms for the implementation of the multivariate schemes. This study also compares the promising multivariate encryption and signature schemes. The critical open challenges that are reviewed in this survey will serve as a single comprehensive source of information on multivariate encryption and signature schemes and a ready reference for researchers working in this rising area of public key cryptography.
A Systematic Survey of General Sparse Matrix-matrix Multiplication
Authors: Gao Jianhua , Ji Weixing , Chang Fangli , Han Shiyu , Wei Bingxin , Liu Zeming , Wang Yizhuo
Published: November 2022

General Sparse Matrix-Matrix Multiplication (SpGEMM) has attracted much attention from researchers in graph analyzing, scientific computing, and deep learning. Many optimization techniques have been developed for different applications and computing architectures over the past decades. The objective of this article is to provide a structured and comprehensive overview of the researches on SpGEMM. Existing researches have been grouped into different categories based on target architectures and design choices. Covered topics include typical applications, compression formats, general formulations, key problems and techniques, architecture-oriented optimizations, and programming models. The rationales of different algorithms are analyzed and summarized. This survey sufficiently reveals the latest progress of SpGEMM research to 2021. Moreover, a thorough performance comparison of existing implementations is presented. Based on our findings, we highlight future research directions, which encourage better design and implementations in later studies.
Judging a Socially Assistive Robot by Its Cover: The Effect of Body Structure, Outline, and Color on Users’ Perception
Authors: Liberman-Pincu Ela , Parmet Yisrael , Oron-Gilad Tal
Published: November 2022

Socially assistive robots (SARs) aim to provide assistance through social interaction. Previous studies contributed to understanding users’ perceptions and preferences regarding existing commercially available SARs. Yet very few studies regarding SARs’ appearance used designated SAR designs, and even fewer evaluated isolated visual qualities (VQs). In this work, we aim to assess the effect of isolated VQs systematically. To achieve this, we first conducted market survey and deconstructed the VQs attributed to SARs. Then, a reconstruction of body structure, outline, and color scheme was done, resulting in the creation of 30 new SAR models that differ in their VQs, allowing us to isolate one character at a time. We used these new designs to evaluate users’ preferences and perceptions in two empirical studies. Our empirical findings link VQs with perceptions of SAR characteristics. These can lead to forming guidelines for the industrial design processes of new SARs to match user expectations.
15 Years of (Who)man Robot Interaction: Reviewing the H in Human-Robot Interaction
Authors: Winkle Katie , Lagerstedt Erik , Torre Ilaria , Offenwanger Anna
Published: November 2022

Recent work identified a concerning trend of disproportional gender representation in research participants in Human–Computer Interaction (HCI). Motivated by the fact that Human–Robot Interaction (HRI) shares many participant practices with HCI, we explored whether this trend is mirrored in our field. By producing a dataset covering participant gender representation in all 684 full papers published at the HRI conference from 2006–2021, we identify current trends in HRI research participation. We find an over-representation of men in research participants to date, as well as inconsistent and/or incomplete gender reporting, which typically engages in a binary treatment of gender at odds with published best practice guidelines. We further examine if and how participant gender has been considered in user studies to date, in-line with current discourse surrounding the importance and/or potential risks of gender based analyses. Finally, we complement this with a survey of HRI researchers to examine correlations between who is doing with the who is taking part, to further reflect on factors which seemingly influence gender bias in research participation across different sub-fields of HRI. Through our analysis, we identify areas for improvement, but also reason for optimism, and derive some practical suggestions for HRI researchers going forward.
Survey of Hallucination in Natural Language Generation
Authors: Ji Ziwei , Lee Nayeon , Frieske Rita , Yu Tiezheng , Su Dan , Xu Yan , Ishii Etsuko , Bang Ye Jin , Madotto Andrea , Fung Pascale
Published: November 2022

Natural Language Generation (NLG) has improved exponentially in recent years thanks to the development of sequence-to-sequence deep learning technologies such as Transformer-based language models. This advancement has led to more fluent and coherent NLG, leading to improved development in downstream tasks such as abstractive summarization, dialogue generation, and data-to-text generation. However, it is also apparent that deep learning based generation is prone to hallucinate unintended text, which degrades the system performance and fails to meet user expectations in many real-world scenarios. To address this issue, many studies have been presented in measuring and mitigating hallucinated texts, but these have never been reviewed in a comprehensive manner before.

In this survey, we thus provide a broad overview of the research progress and challenges in the hallucination problem in NLG. The survey is organized into two parts: (1) a general overview of metrics, mitigation methods, and future directions, and (2) an overview of task-specific research progress on hallucinations in the following downstream tasks, namely abstractive summarization, dialogue generation, generative question answering, data-to-text generation, and machine translation. This survey serves to facilitate collaborative efforts among researchers in tackling the challenge of hallucinated texts in NLG.
Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Bushen Hugu Decoction in the Treatment of Malignant Tumor Bone Metastases
Authors: Sang Tianqing , Zhang Tengfei , Wang Juntao , Zheng Yuling
Published: November 2022

Purpose. To explore the active compounds of the Chinese medicine prescriptions of Bushen Hugu Decoction (BHD) and demonstrate its mechanisms against malignant tumor bone metastasis (BM) through network pharmacology and molecular docking analysis.Methods. The main components and targets of BHD were retrieved from the TCMSP database, and the targets were normalized by UniProt. The Herbs‐Components‐Targets network of BHD was established by Cytoscape. The main BM targets were obtained from GeneCards, TTD, DrugBank, and OMIM. STRING and Cytoscape were used to construct a PPI network and obtain hub genes. DAVID and Metascape were used for GO and KEGG enrichment analyses. According to the network topology parameters, the top 4 components were selected for molecular docking verification with the core targets. Results. Compound–target network of BHD mainly contained 51 compounds and 259 corresponding targets including 107 BHD‐BM targets. PPI interaction network and subnetworks identified ten hub genes. GO enrichment analysis found 1970 terms (p < 0.05), and 164 signaling pathways (p < 0.05) were found in KEGG, including PI3K‐Akt signaling pathway, proteoglycans in cancer, prostate cancer, MAPK signaling pathway, and IL‐17 signaling pathway. Molecular docking analysis showed that the active components of BHD, quercetin, luteolin, kaempferol, and aureusidin have good binding activity to the core targets. Conclusion. The potential molecular target and signaling pathways were found for BHD major active components. It provides guidance for the future mechanism research of the BHD in malignant tumor bone metastasis. This study also established the foundation for the new strategy for the pharmacology study of Chinese medicine.
Evaluation of the Reliability and Quality of YouTube Video Content about Perianal Fistulas
Authors: Eroglu Ersan , Altinli Ediz
Published: November 2022

Objective. Perianal fistulas of the perianal soft tissues are an important cause of morbidity and a significant portion of colorectal surgery. To our knowledge, there is no study evaluating YouTube videos pertaining perianal fistulas. In this study, we aimed to evaluate YouTube video contents on this topic. Methods. Whether the videos contained real images, animations or presentations, video duration, number of views, comments and likes, uploading date, and daily view were recorded. Reliability of the videos was assessed using the Quality Criteria for Consumer Health Information (DISCERN) scale and quality of the videos using the Global Quality Score (GQS). Results. A total of 100 YouTube videos regarding perianal fistulas were included in the study. Sixty‐four (64%) videos were uploaded by healthcare professionals and 36 (36%) videos by nonprofessionals. The mean video length was calculated as 6.70 ± 8.00 minutes for all videos. The mean DISCERN score of all videos was found as 3.92 ± 0.81 and the mean GQS score as 3.97 ± 0.83. According to the DISCERN score, most videos included (94%) were of good quality. There was an excellent agreement between the two surgeons in terms of the DISCERN and GQS scores. Conclusion. Most of the videos included in the study were uploaded by health‐care professionals. On the other hand, the majority of the videos contained surgical management of perianal fistulas as it is the definitive treatment. Healthcare related content should be audited and filtered by YouTube with new and effective policies.
Evaluating the Optimal Operating Table Height for ProSeal-LMA™ Insertion
Authors: Low Song Lin , Masdar Azlina , Md. Nor Nadia , Mohd Azidin Azrin , Low Hsueh Jing , Mohamad Mahdi Siti Nidzwani
Published: November 2022

Introduction. ProSeal-Laryngeal Mask Airway™ (P-LMA™) is one of the commonly used laryngeal mask airways. Despite the proper insertion technique, suboptimal positioning and airway morbidity still occurs. This study explored the possibility of the operating table height position affecting successful P-LMA™ placement. Methods. A total of 138 patients aged between 18 and 65 years old with the American Society of Anesthesiologists (ASA) I or II status, who required general anaesthesia and had no contraindication towards the use of P-LMA™, were recruited. They were randomly positioned into three anatomical landmarks, which were umbilicus, lowest rib margin, and xiphoid. P-LMA™ was inserted following muscle paralysis, and the first successful placement was evaluated using positional and performance tests. Duration, ease of P-LMA™ insertion, and airway complications were compared. Results. Demographic and airway features were comparable among all groups. The P-LMA™ placement success rate improved when the table height was positioned at the lowest rib margin (

p
=
0.002

). All three positions were comparable in terms of duration, ease of insertion, and airway morbidities. Conclusion. The lowest rib margin anatomical landmark can be used as a guide in achieving the optimal operating table height for successful P-LMA™ placement.
Next‐Generation Probiotics: Microflora Intervention to Human Diseases
Authors: Zhang Huanchang , Duan Yunfeng , Cai Feng , Cao Demin , Wang Lei , Qiao Zhenyi , Hong Qing , Li Nan , Zheng Yuanrong , Su Miya , Liu Zhenmin , Zhu Baoli
Published: November 2022

With the development of human genome sequencing and techniques such as intestinal microbial culture and fecal microbial transplantation, newly discovered microorganisms have been isolated, cultured, and researched. Consequently, many beneficial probiotics have emerged as next‐generation probiotics (NGPs). Currently, “safety,” “individualized treatment,” and “internal interaction within the flora” are requirements of a potential NGPs. Furthermore, in the complex ecosystem of humans and microbes, it is challenging to identify the relationship between specific strains, specific flora, and hosts to warrant a therapeutic intervention in case of a disease. Thus, this review focuses on the progress made in NGPs and human health research by elucidating the limitations of traditional probiotics; summarizing the functions and strengths of Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides fragilis, Eubacterium hallii, and Roseburia spp. as NGPs; and determining the role of their intervention in treatment of certain diseases. Finally, we aim to provide a reference for developing new probiotics in the future.
Multitarget and Multipathway Regulation of Zhenqi Fuzheng Granule against Non-Small Cell Lung Cancer Based On Network Pharmacology and Molecular Docking
Authors: Zhou Yanqing , Wu Chenxi , Qian Xian , Zhou Jin , Li Chengjian , Jiao Yang , Li Yue Yue , Zhao Liang
Published: November 2022

Background and Objective. The morbidity and mortality rates of non-small cell lung cancer (NSCLC) remain high. Zhenqi Fuzheng (ZQFZ) granule, which consists of Astragali Radix and Ligustri Lucidi Fructus, is commonly used to improve the immunity of cancer patients. However, the mechanism of ZQFZ granule against NSCLC is still unclear. In this study, the network pharmacology and molecular docking approaches were used to investigate the potential mechanism of ZQFZ granule on NSCLC. Methods. The ingredients in the ZQFZ granule were considered in one study based on UPLC, and the potential targets were predicted in the SwissTargetPrediction database. NSCLC targets were gathered from GeneCards, OMIM, and TTD databases. The ingredient-target-NSCLC network was drawn by Cytoscape. The protein–protein interaction was obtained from the STRING database, and the gene function and biological pathways were analyzed by Metascape. AutoDock Vina was used to verify the molecular docking between the key compounds and core targets, and PyMol visualized the results. Results. 244 targets were related to 13 candidate compounds and 1904 targets were related to NSCLC, of which a total of 106 anti-NSCLC targets were predicted. The compound-target-NSCLC network indicated that sinapinic acid, ferulic acid, asiatic acid, pratensein, and glycitein might be the key components for treating NSCLC. The 41 vital targets (out of 106 targets) above the median calculated by PPI degree were selected for bioinformatics analysis. The top 10 targets out of 41 ranked by MCC were IL-6, SRC, CTNNB1, STAT3, CASP3, TNF, EGFR, MAPK8, HSP90AA1, and PTGS2. ZQFZ granule treatment for NSCLC involved many pathways through KEGG analyses, which included pathways in cancer (hsa05200), proteoglycans in cancer (hsa05205), endocrine resistance (hsa01522), microRNAs in cancer (hsa05206), PI3K-Akt signaling pathway (hsa04151), and IL-17 signaling pathway (hsa04657). Molecular docking studies revealed that sinapinic acid, ferulic acid, asiatic acid, pratensein, and glycitein had good infinity with most core targets. Conclusions. This study indicated that ZQFZ granule with multicompounds could treat NSCLC through multitargets and multipathways.
Potential Antimicrobe Producer of Endophytic Bacteria from Yellow Root Plant (Arcangelisia flava (L.)) Originated from Enggano Island
Authors: Sipriyadi  , Masrukhin  , Wibowo Risky Hadi , Darwis Welly , Yudha Salprima , Purnaningsih Ismu , Siboro Resli
Published: November 2022

Exploration studies of endophytic bacteria from Arcangelisia flava (L.) and their potential have not much been conducted. This research aims to explore and characterize the antimicrobial activity of endophytic bacteria in A. flava against pathogenic bacteria. This research consists of several steps including the isolation of bacteria, screening of the antimicrobial activity assay using the dual cross streak method, molecular identification through 16s rDNA analysis, and characterization of bioactive compound production through PKS-NRPS gene detection and GC-MS analysis. There are 29 endophytic bacteria that were successfully isolated from A. flava. The antimicrobial activity showed that there are four potential isolates AKEBG21, AKEBG23, AKEBG25, and AKEBG28 that can inhibit the growth of pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The 16S rDNA sequence analysis showed that these isolates are identified as Bacillus cereus. These four isolates are identified as able to produce the bioactive compounds through the detection of polyketide synthase (PKS) and nonribosomal peptide synthase (NRPS)-encoding genes. B. cereus AKEBG23 has the highest inhibition against pathogenic bacteria, and according to the GC-MS analysis, five major compounds are allegedly involved in its antimicrobial activity such as butylated hydroxytoluene (BHT), diisooctyl phthalate, E-15-heptadecenal, 1-heneicosanol, and E-14-hexadecenal. This result suggested that B. cereus AKEBG23 as the endophytic bacterium from A. flava has a beneficial role as well as the plant itself. The bacterium produces several bioactive compounds that are allegedly involved in its antimicrobial activity against pathogenic bacteria.
Neem: A Novel Biocide for Pest and Disease Control of Plants
Authors: Adusei Stephen , Azupio Samuel
Published: November 2022

Plant extracts have recently captivated scientists’ attention as a potential source of biocide for plant protection. This is due to the health and environmental risks associated with the widespread use of synthetic chemicals with adverse effects on humans, nontarget organisms, and the agroecosystem. As a result, more environmentally friendly and safe alternative approaches to synthetic compounds are desirable. Neem (Azadirachta indica) has been identified as a promising biocontrol agent with low toxicity and high efficacy among several plant products for potential chemotherapeutic elements in plant pest and disease management systems. The biocidal potency of neem is attributed to its azadirachtin active ingredient, which impacts some metabolic processes in insects such as protein synthesis, changes in biological fitness, impaired sexual communication, and chitin synthesis. This systematic review intends to gather all the available scientific data regarding the application of neem and its formulations in pest and disease control of plants. The PRISMA (preferred reporting items for systematic reviews and meta-analysis) framework was employed in collecting data for the study. Findings from this review study have demonstrated the use of neem as an effective biocontrol agent for plants’ pests and diseases and have provided a solid foundation for future studies on the plant.
Vitamin D Receptor Gene Polymorphisms and the Risk of CIN2+ in Shanxi Population
Authors: Li Dongyan , Liu Yan , Kong Dangyi , Papukashvili Dimitri , Rcheulishvili Nino , Zhao Hongwei , Li Yinge , Hou Chaiyun , Ma Jinfeng , Lu Xiaoqing , Bai Wenqi
Published: November 2022

Cervical cancer is one of the most common malignancies in women with high morbidity and mortality. Human papillomavirus (HPV) infection is the primary cause of cervical cancer, of which HPV 16 is the predominant. Early detection and effective treatment of cervical precancerous lesions are the key to preventing cervical cancer. Vitamin D receptor (VDR) gene polymorphism is considered to be an important cause of cancer development. Here, we studied the association of VDR polymorphisms (FOKI, BsmI, ApaI, and TaqI) in HPV16‐positive cervical intraepithelial neoplasia (CIN)2+ patients. HPV16‐positive patients who visited the Colposcopy Clinic of Obstetrics and Gynecology, the Second Hospital of Shanxi Medical University for biopsy due to abnormal HPV and/or Thinprep cytologic test (TCT) from September 1, 2020 to October 1, 2021 were grouped by pathological results. The fasting blood samples were collected and VDR polymorphisms were detected using TaqMan fluorescent probes, and the three sites of BsmI‐ApaI‐TaqI were subjected to haplotype analysis. FOKI ff genotype (OR = 2.01; 95% CI = 1.12 − 3.59; p = 0.019) and f allele (OR = 1.48; 95% CI = 1.10 − 1.98; p = 0.009) were found to be associated with the risk of CIN2+. TaqI Tt genotype (OR = 2.03; 95% CI = 1.20 − 3.43; p = 0.008), tt genotype (OR = 2.09; 95% CI = 1.09 − 4.02; p = 0.028), and t allele (OR = 1.35; 95% CI = 1.01 − 1.80; p = 0.041) were associated with the risk of CIN2+. No haplotype was associated with CIN2+ risk. According to the results, FOKI and TaqI polymorphisms are associated with CIN2+ risk.
[Retracted] Safety Evaluation and Effect Deconstruction of Blood Lipid Test in the Diagnosis of Cardiovascular Disease Patients
Authors: Yang Xiaochun , Lu Zhen
Published: November 2022

With the increase in the number of cardiovascular patients in China, this paper must use better detection methods to examine these patients. Blood lipid testing is a quantitative method for the determination of lipids contained in blood (plasma). Blood lipids are the general term for neutral fats (triglycerides and cholesterol) and lipids (phospholipids, glycolipids, sterols, and steroids) in plasma, which are widely present in the human body. At the same time, this paper also applies this technology to different examination procedures at various current stages. Cardiovascular disease, also known as circulatory system disease, is a series of diseases involving the circulatory system. The circulatory system refers to the organs and tissues that transport blood in the human body, mainly including the heart and blood vessels (arteries, veins, and microvessels), which can be subdivided into acute and chronic and are generally related to arteriosclerosis. In recent years, the most widely used is blood lipid measurement. Therefore, this paper proposes a study on the safety evaluation and effect analysis of blood lipid testing in the diagnosis of cardiovascular disease patients. This article focuses on the causes of cardiovascular disease and introduces the purpose, methods, results, and conclusions of blood lipid detection. Combined with the deep learning method combined with wavelet analysis and support vector machine (SVM), the in‐depth analysis is carried out, and suitable patients are selected for blood lipid detection. The final experimental results showed that apolipoprotein B (APOB), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), triglyceride (TG), and other indicators were significantly different from the control group. The values of apolipoprotein A1 (APOA1) and high‐density lipoprotein cholesterol (HDL‐C) were significantly different from those in the control group, P < 0.05. This shows that blood lipid examination has a good effect on the diagnosis of cardiovascular patients; it can make accurate diagnosis and prediction of the patient’s condition and has good clinical application value.
Clinical Characteristics, Outcomes, and Risk Factors for Patients with Diffuse Large B-Cell Lymphoma and Development of Nomogram to Identify High-Risk Patients
Authors: Zhao Jinrong , Zhang Yan , Wang Wei , Zhang Wei , Zhou Dao-bin
Published: November 2022

Objectives. To analyse the clinical features, outcomes, and risk factors of patients with diffuse large B-cell lymphoma (DLBCL) in China, with the aim to establish a new prognostic model based on risk factors. Methods. Clinical features and outcomes of 564 patients newly diagnosed with DLBCL from Jan 2009 to May 2017 were analyzed retrospectively. Variables were screened by LASSO regression and nomogram was constructed. Results. The 5-year overall survival (OS) of the cohort was 75%. The 5-year OS of patients differentiated by International Prognostic Index (IPI) score was 90% (score 0–2), 73% (score 3), and 51% (score 4-5), respectively. Age > 60, Eastern Cooperative Oncology Group (ECOG) > 1, Ann Arbor stage III-IV, bone marrow involvement, low level of albumin (ALB), and lymphatic/monocyte ratio (LMR) were independent predictors of OS. The predictive model was developed based on factors including age, bone marrow involvement, LMR, ALB, and ECOG scores. The predictive ability of the model (AUC, 0.77) was better than that of IPI (AUC, 0.74) and NCCN-IPI (AUC, 0.69). The 5-year OS of patients in the low-, intermediate-, and high-risk groups identified by the new predictive model was 89%, 70%, and 33%, respectively. Conclusions. The new prediction model had better predictive performance and could better identify high-risk patients.
The Effect and Safety of Xuefu Zhuoyue Prescription for Coronary Heart Disease: An Overview of Systematic Reviews and Meta-Analyses
Authors: Shi Hongshuo , Tang Zunhao , Liu Ting , Zhang Xuecheng , Wang Yao , Li Jie , Dong Chengda , Chen Wenqiang , Hou Ruirui , Si Guomin , Liu Yan
Published: November 2022

Background. In China, the traditional Chinese medicine compound Xuefu Zhuoyue prescription (XFZY) has been widely used in the therapy of coronary heart disease (CHD). Currently, several systematic reviews (SRs)/meta-analyses (MAs) of XFZY for the treatment of CHD have been published. This overview aims to evaluate the existing SRs/MAs and provide a scientific basis for evaluating the efficacy and safety of XFZY for the therapy of CHD. Methods. The SRs/MAs of XFZY for the treatment of CHD were obtained from 7 electronic databases with the search date set at March 7, 2022. Two researchers independently assessed the methodological quality, reporting quality, and evidence quality of the included SRs/MAs using the following tools: the Assessment of Multiple Systematic Reviews 2 (AMSTAR-2), the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA 2020), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results. A total of 11 SRs/MAs were included in this overview. All SRs/MAs assessed by means of AMSTAR-2 had more than one critical defect, so all SRs/MAs were rated low. Regarding the assessment of reporting quality, the results of PRISMA 2020 showed that none of the SRs/MAs were fully reported. In addition, the results of the GRADE assessment of the quality of evidence indicated that only one outcome was rated as high quality across all SRs/MAs. Conclusion. Current evidence suggests that XFZY is effective and safe for the management of patients with CHD. However, the high risk of bias of the original clinical studies and the low quality of the SRs/MAs reduced the reliability of the results.
Analysis of Mechanical Properties and Slope Stability of Red Bed Soft Rock: A Case Study in Xinjiang Irrigation Diversion Channel
Authors: Liu Da , Gao Jianglin , Chen Fang , Hu Songtao , Zhao Xiaohua , Li Yan
Published: November 2022

The channel slope in the red‐bed soft rock area is prone to instability and collapse due to the influence of the channel flow movement, rainfall, weathering, and other factors. Under long‐term operation conditions, the sediment stripped from the channel side wall is liable to silt along the process of water flow transportation in the channel, which seriously leads to elevation of the channel bottom, increase of channel width, and reduction of the horseway, which affect the normal water conveyance and operation safety of channels. In view of the collapse and instability of Zhetang diversion irrigation channel project in Xinjiang hydraulic project, through on‐site sampling and indoor rock mechanics test, the strength mechanical parameters of slope rock samples are obtained, and the indoor rheological test is carried out, and the triaxial rheological law is obtained. Under different levels of stress, the axial creep strain accounts for more than 50% of the total axial strain, indicating that the rheological effect of sample rock is obvious. Based on the strength parameters of rock samples, a numerical model is established. The stability of red‐bed soft rock channel bank slope is studied by using the strength reduction method of finite element method. The seepage field of channel slope under conventional working conditions is analyzed, and the slope stability under different operating conditions is compared and calculated. The results show that the slope stability safety factor of Zhetang diversion irrigation channel slope is 1.60 under conventional working conditions and 1.33 under check working conditions, which are greater than the recommended value in the specification.
Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Authors: Soni Upendra Kumar , Wang Yuhua , Pandey Ram Naresh , Roberts Ryan , Pressey Joseph G. , Hegde Rashmi S.
Published: November 2022

Purpose:

Targeted cancer therapeutics have not significantly benefited patients with Ewing sarcoma with metastatic or relapsed disease. Understanding the molecular underpinnings of drug resistance can lead to biomarker-driven treatment selection.

Experimental Design:

Receptor tyrosine kinase (RTK) pathway activation was analyzed in tumor cells derived from a panel of Ewing sarcoma tumors, including primary and metastatic tumors from the same patient. Phospho-RTK arrays, Western blots, and IHC were used. Protein localization and the levels of key markers were determined using immunofluorescence. DNA damage tolerance was measured through PCNA ubiquitination levels and the DNA fiber assay. Effects of pharmacologic inhibition were assessed in vitro and key results validated in vivo using patient-derived xenografts.

Results:

Ewing sarcoma tumors fell into two groups. In one, IGF1R was predominantly nuclear (nIGF1R), DNA damage tolerance pathway was upregulated, and cells had low replication stress and RRM2B levels and high levels of WEE1 and RAD21. These tumors were relatively insensitive to IGF1R inhibition. The second group had high replication stress and RRM2B, low levels of WEE1 and RAD21, membrane-associated IGF1R (mIGF1R) signaling, and sensitivity to IGF1R or WEE1-targeted inhibitors. Moreover, the matched primary and metastatic tumors differed in IGF1R localization, levels of replication stress, and inhibitor sensitivity. In all instances, combined IGF1R and WEE1 inhibition led to tumor regression.

Conclusions:

IGF1R signaling mechanisms and replication stress levels can vary among Ewing sarcoma tumors (including in the same patient), influencing the effects of IGF1R and WEE1 treatment. These findings make the case for using biopsy-derived predictive biomarkers at multiple stages of Ewing sarcoma disease management.
Tocilizumab as a Useful Tool for Thyroid Eye Disease in Pediatric Population: A Case Report
Authors: Moleiro Ana Filipa , Vilares-Morgado Rodrigo , Alves Gonçalo Coutinho , Rodrigues Mariana , Falcão-Reis Fernando , Magalhães Augusto , Leal Vitor , Meira Jorge
Published: November 2022

Thyroid eye disease (TED) characterizes by inflammation and remodeling of orbital tissues. Although the majority of pediatric TED is mild, some children present progressive and severe disease. The approach to severe disease in this group of patients, especially when noncortico-responsive, is challenging. The purpose of this work was to describe the effective use of tocilizumab as second-line therapy in steroid-resistant pediatric TED. A 13-year-old female with a history of Graves’ disease presented with right eye proptosis for at least 8 months associated with mild pain on eye movements and ocular surface complaints. The ophthalmologic evaluation revealed Hertel exophthalmometry readings of 22 mm on the right eye (OD) and 19 mm on the left (OS). The remaining ophthalmic examination was unremarkable. Intravenous methylprednisolone pulses of 500 mg were initiated without any improvement after 4 treatments. Following multidisciplinary team discussion, therapy was switched to monthly tocilizumab injections at 4 mg/kg. Significant reduction of proptosis and resolution of pain and ocular surface complaints were noted immediately after the treatment switch. Exophthalmometry readings after the end of treatment that included 4 tocilizumab injections were 20 mm on OD and 19 mm on OS. No side effects were reported during the entire follow-up. Six months after treatment cessation, the patient remains stable, without any signs of orbitopathy relapse and no ophthalmologic complaints. This is the second case report showing the effectiveness of tocilizumab in pediatric TED and the first one showing its efficacy when steroids fail. Our results support the potential safety and efficacy of this immunosuppressor in children with TED.
Effects of Eligibility Criteria on Patient Selection and Treatment Implications from 10 Multidomain Dementia Prevention Trials: A Population-Based Study
Authors: Licher Silvan , Wolters Frank J. , Pavlović Jelena , Kavousi Maryam , Leening Maarten J.G. , Ikram M. Kamran , Ikram M. Arfan
Published: November 2022

Introduction: Dementia prevention trials have so far shown little benefit of multidomain interventions against cognitive decline. Recruitment strategies in these trials often centre around dementia risk or cardiovascular risk profile, but it is uncertain whether this leads to inclusion of individuals who may benefit most from the intervention. We determined the effects of eligibility criteria on the recruitment of potential trial participants in the general population. Methods: In a systematic search until January 1, 2022, we identified all published and ongoing large (≥500 participants), phase-3 multidomain trials for the prevention of cognitive decline or dementia. We applied trial eligibility criteria to 5,381 participants of the population-based Rotterdam Study (mean age: 72 years, 58% women), to compare participant characteristics, predicted risk of cardiovascular disease, and dementia risk, between trial eligible and ineligible persons. Results: We identified 10 trials, of which 5 had been published (DR’s EXTRA, FINGER, preDIVA, MAPT, and HATICE) and 5 are ongoing (US-POINTER, MIND-CHINA, MYB, AgeWell.de, and J-Mint). Among all Rotterdam Study participants, eligibility across published trials ranged from 48% for MAPT to 87% for preDIVA, in line with original trial reports. Variability in eligibility was wider for ongoing trials, from 1% for US-POINTER to over 94% for MYB trial. Over 70% of trial eligible individuals are recommended preventive intervention in routine care based on their cardiovascular risk, similar for lipid-lowering (71%) and blood pressure-lowering treatment (73%). Ten-year risks of dementia were similar for eligible compared to ineligible individuals (12 vs. 11%). Conclusion: Multidomain dementia prevention trials fail to preferentially include those at the highest risk of dementia and mostly include individuals who qualify for interventions already on the basis of cardiovascular prevention guidelines. These findings call for better targeted enrolment of individuals for whom trial results can improve clinical decision-making.
ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice
Authors: Babu Mohan , Devi Durga , Mäkinen Petri , Örd Tiit , Aavik Einari , Kaikkonen Minna , Ylä-Herttuala Seppo
Published: November 2022

Background:

Diabetes is a major risk factor for peripheral arterial disease. Clinical and preclinical studies suggest an impaired collateral remodeling and angiogenesis in response to atherosclerotic arterial occlusion in diabetic conditions, although the underlying mechanisms are poorly understood.

Objective:

To clarify the cellular and molecular mechanisms underlying impaired postischemic adaptive vascular responses and to evaluate rHDL (reconstituted HDL)-ApoA-I nanotherapy to rescue the defect in type 2 diabetic mouse model of hindlimb ischemia.

Methods and Results:

Hindlimb ischemia was induced by unilateral femoral artery ligation. Collateral and capillary parameters together with blood flow recovery were analyzed from normoxic adductor and ischemic gastrocnemius muscles, respectively, at day 3 and 7 post-ligation. In response to femoral artery ligation, collateral lumen area was significantly reduced in normoxic adductor muscles. Distally, ischemic gastrocnemius muscles displayed impaired perfusion recovery and angiogenesis paralleled with persistent inflammation. Muscle-specific mRNA sequencing revealed differential expression of genes critical for smooth muscle proliferation and sprouting angiogenesis in normoxic adductor and ischemic gastrocnemius, respectively, at day 7 post-ligation. Genes typical for macrophage (Mϕ) subsets were differentially expressed across both muscle types. Cell-specific gene expression, flow cytometry, and immunohistochemistry revealed persistent IFN-I response gene upregulation in arterial endothelial cells, ECs and Mϕs from T2DM mice associated with impaired collateral remodeling, angiogenesis and perfusion recovery. Furthermore, rHDL nanotherapy rescued impaired collateral remodeling and angiogenesis through dampening EC and Mϕ inflammation in T2DM mice.

Conclusions:

Our results suggest that an impaired collateral remodeling and sprouting angiogenesis in T2DM mice is associated with persistent IFN-I response in ECs and Mϕs. Dampening persistent inflammation and skewing ECs and Mϕ phenotype toward less inflammatory ones using rHDL nanotherapy may serve as a potential therapeutic target for T2DM peripheral arterial disease.
Association of Home and Ambulatory Blood Pressure With Cardiovascular Prognosis in Practice Hypertensive Outpatients
Authors: Narita Keisuke , Hoshide Satoshi , Kario Kazuomi
Published: November 2022

Background:

Although international guidelines for hypertension management recommend home and ambulatory blood pressure (BP) monitoring, few studies have assessed which is more useful in predicting cardiovascular incidence in hypertensive outpatients.

Methods:

We analyzed the association of home and ambulatory BP with cardiovascular prognosis in 1336 practice outpatients with hypertension who underwent both home and ambulatory BP measurements in the J-HOP study (Japan Morning Surge-Home Blood Pressure).

Results:

During the median 6.9 years of follow-up, 111 cardiovascular events occurred. Both home and ambulatory systolic BP (SBP) were associated with cardiovascular risk independent of office SBP (hazard ratio [95% CI] per 20 mm Hg of average morning and evening home SBP, 1.46 [1.11–1.93]; 24-hour ambulatory SBP, 1.41 [1.02–1.94]). Moreover, average morning and evening home SBP was also associated with cardiovascular risk even adjusted by 24-hour ambulatory SBP (hazard ratio [95%CI] per 20 mm Hg, 1.38 [1.01–1.87]), but 24-hour ambulatory SBP was not associated with cardiovascular risk adjusted by average morning and evening home SBP. Regarding this relationship, the model-fit was significantly improved by using the analysis of likelihood ratio, but that was not significant in the analysis using C statistics. Additionally, even in patients with well-controlled 24-hour ambulatory BP, uncontrolled morning home BP was associated with cardiovascular risks (hazard ratio [95% CI], 2.15 [1.02–4.50]). In patients with well-controlled average morning and evening home BP, uncontrolled ambulatory BP was not associated with cardiovascular risks.

Conclusions:

This study demonstrated the prognostic values of home and ambulatory BP in practice hypertensive outpatients. Our findings indicated the modest superiority of home BP compared to ambulatory BP to predict cardiovascular prognosis.
Gibellula aurea sp. nov. (Ascomycota, Cordycipitaceae): a new golden spider-devouring fungus from a Brazilian Atlantic Rainforest
Authors: MENDES-PEREIRA THAIRINE , MACHADO DE ARAÚJO JOÃO PAULO , CARVALHO MENDES FLÁVIA , OLIVEIRA FONSECA EMILY , ERICA DA ROCHA ALVES JULIE , FERNANDO SOBCZAK JOBER , GÓES-NETO ARISTÓTELES
Published: November 2022

Fungal parasites that infect spiders can affect their survival and potentially their behaviour. The genus Gibellula (Ascomycota, Cordycipitaceae) infects arachnids, and due to difficulties in identifying hosts after fungal sporulation, its ecology and spider host diversity are poorly understood. Herein, we propose a new species of Gibellula from the Brazilian Atlantic Forest: Gibellula aurea, which parasitizes two spider families (Anyphaenidae and Corinnidae). Gibellula aurea exhibits characteristic golden-yellow hyphae that completely cover hosts and white conidiophores emerging along synnemata or directly from hosts. Molecular identification was performed by sequencing the small and large nuclear ribosomal subunits, translation elongation factor, and RNA polymerase II second largest subunit regions, and reconstructing multigene phylogenetic trees. Maximum Likelihood and Bayesian Inference phylogenies demonstrate that G. aurea forms a well-supported clade closer to G. flava, G. gamsii, G. leiopus, G. longispora, G. pigmentosinum, and G. pulchra. The phylogenetic reconstruction displayed herein represents the most comprehensive phylogeny for this genus to date. Spider hosts parasitized by G. aurea have been invariably found attached underneath leaves in vegetation, regardless of the identity of the infected hosts. The consistency of the death locations of G. aurea hosts indicates recurrent behaviour given the habitat heterogeneity of these host groups. Nevertheless, it is still unclear to what extent the place where hosts die can favour parasite fitness.
Examining the reliability and validity of the ICD-11 personality disorder severity diagnosis
Authors: Brown Tiffany A , Sellbom Martin
Published: November 2022

Objectives:

The International Classification of Diseases, 11th edition includes a new personality disorder diagnosis, in light of growing concerns of the categorical personality disorder diagnoses. The purpose of the current study was to examine the reliability and validity of the severity dimension of the new International Classification of Diseases, 11th edition diagnosis, through multi-method assessment.

Method:

In a community mental health sample ( n = 311), we examined the interrater reliability of the severity diagnosis and evaluated the diagnosis against self-report measures of dimensional personality pathology and psychopathology constructs and traditional categorical and informant-report measures.

Results:

Intraclass correlations indicated ‘excellent’ reliability of the diagnostic ratings. Large associations were observed between the International Classification of Diseases, 11th edition clinician diagnosis and overall impairment measures. Generally, the International Classification of Diseases, 11th edition clinician diagnosis exhibited largest associations with measures of internalising dysfunction, and more variable associations with interpersonal and externalising impairment. The International Classification of Diseases, 11th edition clinician diagnosis showed a large association with borderline personality disorder symptom scores and moderate associations with Paranoid, Schizoid and Avoidant personality disorder scores. Similar patterns emerged of the associations between the International Classification of Diseases, 11th edition personality disorder diagnosis with self-report and informant-report measures, although the associations were larger with self-report measures.

Conclusion:

These findings provide promising initial evidence for the reliability and validity of the new International Classification of Diseases, 11th edition personality disorder diagnosis, indicating that the new conceptualisation of personality disorders may address issues within the categorical model.
Book review: Jing Tsu, Kingdom of Characters: A Tale of Language, Obsession, and Genius in Modern China
Authors: Bhoothalingam Ravi
Published: November 2022

Jing Tsu, Kingdom of Characters: A Tale of Language, Obsession, and Genius in Modern China (Allen Lane, 2022), pp. 336, ₹1677. ISBN: 9780241295854.
Introduction: Coloniality, Educational Leadership, and White Supremacy: The Other Global Pandemic
Authors: Marsh Tyson E.J. , Wright James , Khalifa Muhammad , López Gerardo R.
Published: November 2022

In lieu of writing a separate introduction to this special issue, the three guest editors invited the EAQ Editor-In-Chief to join them as a coauthor in their introduction. López, agreed but took a few liberties with the draft that was provided to him by the guest editors. The result is an imagined “conversation” that did not actually take place but is highly probable given the deep admiration and mutual respect the four individuals have for each other both as individuals and as scholars. This introductory conversation situates the theme of the special issue within the larger scope of educational leadership while simultaneously troubling the role of school leaders as agents of Coloniality.