bluuebunny/crossref_metadata_2025 huggingface dataset:
Papillomes intra-ductaux
Authors: Dr Anne de ROQUANCOURT  , Dr Sylvie BONFILS
Published: April 2022

Les papillomes intra-canalaires font partie deslésions papillaires et sont représentés par lespapillomes uniques et les papillomes multiples.Leur fréquence varie de 1 à 8% des lésionsbénignes mammaires biopsiées.Classiquement, la distinction se faisait entrepapillome solitaire souvent retro aréolaire considéré comme bénin et papillomes multiples périphériques représentant des lésions à risque.Actuellement, certains auteurs pensent quepapillomes solitaires et papillomes multiples fontpartie d’un même groupe de mastopathie proliférante et recommandent leur exérèse chirurgicalesystématique même lorsqu’il s’agit d’un papillomesolitaire simple asymptomatique.
Facteurs de croissance et cancers du sein
Authors: Dr Patricia de CREMOUX
Published: April 2022

Les récepteurs de facteurs de croissance et leursignalisation intracellulaire ont un impact majeurdans la cancérogénèse mammaire et le maintientdu phénotype tumoral. De nombreux progrès ontété réalisés ces dernières années dans la compréhension des mécanismes complexes de régulationde ces différents facteurs. Par ailleurs ils sont lacibles de nombreuses molécules dites « thérapeutiques ciblées » dont l’efficacité pour beaucoupd’entre elles a été montrée. Cependant il fautencore améliorer la prédiction de la réponse autraitement au niveau individuel chez les patientesprésentant un cancer du sein.
rradiation partielle accélérée : Pour ou Contre ? POUR une évolution des traitements loco-régionaux dans les cancers de stade précoce vers de nouveaux standards de radiothérapie ?
Authors: C. BOURGIER  , S. HEYMANN
Published: April 2022

Grâce au dépistage organisé, l’incidence de cancers du sein de bon pronostic a augmenté au profitde cancers localement avancés. Le traitement standard de ces cancers du sein dits « de stade précoce » consiste en une chirurgie conservatrice suivie d’une radiothérapie de l’ensemble du sein suivied’une surimpression du lit de tumorectomie étaléesur 5 à 7 semaines dans la plupart des cas. Unschéma d’irradiation alternatif a été récemmentproposé et recommandé par les sociétés savantesaméricaine et européenne pour les patientes à faible risque de récidive locale. Il s’agit d’un traitement par irradiation partielle accélérée du sein(5 jours de traitement au lieu de 6-7 semaines).Nous proposons ici de développer le rationnel de cetraitement, les différentes techniques, les résultatscarcinologiques et effets secondaires de ce traitement.
Stimulation ovarienne seule ou insémination intra utérine sur cycles stimulés
Authors: Joëlle BELAISCH-ALLART  , Jean-Marc MAYENGA  , Veronica GRZEGORCZYK–MARTIN  , Iréne GREFENSTETTE  , Albert CHOURAQUI  , Olivier KULSKI
Published: April 2022

La stimulation de l’ovulation simple, non suivied’insémination intra utérine ne s’adresse qu’auxfemmes présentant une anovulation ou une dysovulation. Elle n’a pas démontré son efficacité dansl’infertilité inexpliquée ou masculine. Le recours àl’association stimulation de l’ovulation - insémination intra utérine est validé dans la littérature encas d’infertilité inexpliquée et, bien que plus discuté, en cas d’infertilité masculine ou cervicale.
Préservation de la fertilité féminine en cas de risque d’altération
Authors: Tristan GAUTHIER  , Pascal PIVER  , Yves AUBARD
Published: April 2022

L’information aux jeunes femmes et aux parents dejeunes filles concernant les techniques de préservationde la fertilité en cas de traitements gonadotoxiques estune obligation médico-légale. En cas de stade précocedes cancers gynécologiques, une chirurgie conservatrice peut parfois être discutée. La congélationembryonnaire et/ou ovocytaire est réservée auxpatientes pubères et nécessitent une stimulation ovarienne incompatible avec un traitement urgent. Lamaturation ovocytaire in vitro semble séduisante. Lacryoconservation de tissu ovarien a l’avantage de pouvoir être proposée chez les jeunes filles non pubères etne retarde pas le traitement. Quant à la protection ducapital folliculaire par les analogues GnRH, les résultats d’études randomisées sont en attente.
L’ostéoporose interpelle le chirurgien orthopédiste
Authors: Pr Charles MSIKA
Published: April 2022

L’ostéoporose, altération au long cours, compromettant la solidité squelettique est une pathologiede fréquence importante et toujours croissante. Ils’agit du type même de maladie sous-diagnostiquéecar longtemps silencieuse. Le ChirurgienOrthopédiste est un observateur privilégié de cetteaffection car l’événement révélateur de cette dernière est la fracture plus spécifiquement la fracturede fragilité. Cette dégradation de la qualité mécanique squelettique impose au chirurgien de nombreux ajustements tant dans son rôle de conseil duPatient que dans son rôle d’exécutant d’une prestation technique de réparation de l’élément squelettique fracturé. Ces ajustements nécessitent de s’intégrer dans un effort de collaboration médicalepluridisciplinaire motivé et suffisamment convaincant pour enrôler l’entière coopération du Patientlui-même.
Prise en charge des patientes prééclamptiques
Authors: B. HADDAD  , A. BERMAN  , D. SKALLI  , M. LEFEBVRE  , C. TOUBOUL
Published: April 2022

La prise en charge de la grossesse chez une patienteayant une prééclampsie conditionne le pronosticmaternel et périnatal. L’analyse des données de lalittérature et les avis d’experts permettent de suggérer des critères de surveillance et d’arrêt de la grossesse, essentiellement pour la PE sévère. Certainesdes indications de l’arrêt de la grossesse sont maternelles: une hypertension sévère non contrôlée, uneéclampsie, un oedème aigu du poumon, un hématome rétroplacentaire, une oligurie persistante, dessignes d’imminence d’une crise d’éclampsie(céphalées ou troubles visuels persistants), une douleur épigastrique persistante, un HELLP syndrome, une insuffisance rénale de novo, ou unterme inférieur à 24 semaines d’aménorrhée.D’autres indications sont fœtales : la présenced’anomalies du rythme cardiaque fœtal, un scorede Manning ≤ 4 à 2 reprises, un oligoamniossévère, une estimation du poids fœtal < 5e percentile au-delà de 30 semaines d’aménorrhée, unediastole ombilicale artérielle inversée au-delà de 30semaines d’aménorrhée. En cas de PE peu sévère,l’arrêt de la grossesse doit être envisagé au-delà de36 SA.
Déportation du trophoblaste et prééclampsie
Authors: Jean-Claude CHALLIER
Published: April 2022

Les trophoblastes jouent un rôle clé dans la pathogenèse de la prééclampsie, en particulier le trophoblaste villeux. Sa déportation dans la circulationmaternelle est examinée en relation avec la fusiondu cytotrophoblaste avec le syncytiotrophoblasteainsi que celle de l’apoptose, la nécrose ou l’aponécrose du syncytiotrophoblaste. Ces mécanismessont altérés dans les phases précliniques et cliniquesde cette maladie. L’alternance de phases d’hypoxieet de ré-oxygénation dans l’espace intervilleux,accélère cette déportation qui retentit sur l’ endothélium vasculaire maternel, ce qui explique enpartie l’hypertension et ses conséquences. Lesdébris trophoblastiques observés en excès dans lesang maternel ou le placenta humain perfusé ontété impliqués. Leur isolement a permis de mettreen évidence des cellules multi-nucléées ou mononucléées, des microparticules et des nanoparticulesprovenant du syncytiotrophoblaste. Les cellulessont éliminées par les poumons, les microparticulesont des effets décrits comme pro-inflammatoires,pro-coagulants et anti-angiogéniques. Les nanoparticules, formées essentiellement d’exosomes,constituent un nouveau système de communicationintercellulaire activement exploré en raison de sonrôle dans de nombreux processus: infection virale,cancer et neuro-dégénérescence. Leur interventiondans l’angiogenèse, la stéroidogenèse ou la tolérance mère-fœtus suggère qu’ils pourraient jouerun rôle dans la prééclampsie.
Prééclampsie : la piste d’ un défaut de la stéroïdogenèse
Authors: Alexandre HERTIG
Published: April 2022

Alors que la physiopathologie du syndrome maternel de préeclampsie est beaucoup mieux comprise,celle de son versant placentaire, qui est le primummovens du syndrome, reste mystérieuse. Les outilsmodernes et spécifiques de mesure des stéroïdescomme la spectrométrie de masse après chromatographie gazeuse, ont cependant permis de détecterune diminution de la synthèse de l’œstradiol dansle sang des femmes accouchant dans un contextede préeclampsie. Ce défaut semble consécutif à undéfaut d’aromatisation des androgènes fœtaux etmaternels par le placenta. Ici, nous faisons l’hypothèse que ce défaut est précoce et joue un rôle causal dans les anomalies de la pseudovasculogénèseplacentaire qui caractérisent mais aussi induisent lapréeclampsie.
Pharmacologie pratique des estrogènes et des progestatifs utilisés en contraception
Authors: NATHALIE BOURCIGAUX  , LUCILE MARAVAL
Published: April 2022

Depuis la découverte de la progestérone et de l’estradiol dans les années 1930, vingt à trente années se sontécoulées avant de la mise en évidence des propriétéscontraceptives des progestatifs et la commercialisationde la première pilule estroprogestative « Enovid ».Les progestatifs de synthèse dérivent soit de la progestérone, soit de la testostérone ou de la spironolactone(drospirénone). Ces deux derniers sont utilisés encontraception seuls ou en association à un estrogènede synthèse, l’ethinyl estradiol (EE), plus rarementavec du valérate d’estradiol ou du 17β-estradiol. Cesont principalement les progestatifs qui confèrentla propriété contraceptive des pilules estroprogestatives et ils sont responsables de la classification« historique » des pilules en générations 1, 2, 3et autres. Parallèlement, la concentration de l’EEcontenue dans les pilules a nettement diminué du faitdu risque thromboembolique. Ainsi, de nombreusescombinaisons estroprogestatives ont été mises aupoint pour améliorer l’efficacité et la tolérance dela contraception.
Contraception hormonale et hyperandrogénies (acné, hirsutisme, alopécie)
Authors: ESTELLE BROUX  , SOPHIE CATTEAU-JONARD
Published: April 2022

L’hyperandrogénie chez la femme se définit parl’ensemble des symptômes résultant d’une production excessive d’androgènes. Sur le plan clinique, onretrouve le plus souvent un hirsutisme, de l’acné etplus rarement une alopécie androgénique. L’origine del’hyperandrogénie peut être ovarienne, surrénalienne,iatrogène ou idiopathique. Dans 4 cas sur 5, on identifieun syndrome des ovaires polymicrokystiques. En casd’hyperandrogénie légère à modérée, la contraception oestroprogestative est le traitement de premièreintention en l’absence de contre-indication. En casd’hyperandrogénie sévère, l’acétate de cyprotéroneassocié à un estrogène est le traitement de choix, enrespectant les nouvelles mesures de précautions liéesau risque de méningiome. En deuxième intention, laspironolactone pourra être prescrit hors AMM, souscouvert d’une contraception efficace.
Contraception et cancers gynécologiques : intox ou vrai danger pour les femmes ?
Authors: CHRISTINE ROUSSET-JABLONSKI1
Published: April 2022

Le risque carcinologique est une inquiétude souventévoquée en consultation de contraception. Cependant,de nombreuses idées reçues persistent et le risque induitest souvent surévalués par les patientes, ainsi que parles professionnels de santé. Une augmentation modérée du risque de cancer du sein est retrouvée en coursd’utilisation de la contraception oestroprogestative.Cette augmentation de risque diminue après l’arrêtde la contraception hormonale. Une augmentationmodérée du risque a également été décrite avec lescontraceptions microprogestatives orales avec desdonnées contradictoires, et reste débattue avec leDIU au LNG à 52mg. La prise d’une contraceptionoestroprogestative entraîne une réduction des risquesde cancers de l’endomètre et de l’ovaire, avec un effetdurée prolongé après l’arrêt. Une réduction des risquesde cancers de l’endomètre et de l’ovaire est égalementretrouvée chez les utilisatrices de DIU au LNG à 52mg. Une augmentation modérée du risque de cancerinfiltrant du col de l’utérus a été décrite chez les utilisatrices de contraception orale, notamment pour lesdurées de prise prolongées, avec un impact qui sembles’estomper après l’arrêt. Lorsque l’on s’intéresse aurisque carcinologique global (tous types de cancersconfondus), les études ne retrouvent pas d’augmentation de l’incidence ou de la mortalité par cancer liée àla prise de contraception orale ou à l’utilisation d’unDIU au LNG. En pratique, les données sur les risquescarcinologiques font partie de l’information donnée,mais ne modifient pas la prescription d’une contraception, les bénéfices en termes contraceptifs restantsupérieurs aux risques. Le choix contraceptif restedépendant d’une balance bénéfice/risque individuelle
In Vitro Comparison of Gutta-Percha Removal Using XP Endo Finisher and ProTaper With or Without Organic Solvent by Scanning Electron Microscope
Authors: Barnawi Ashwag , Al-Guhi May , Baraheem Bayan , Malki Elaf , Almalki Majed , Fansa Hoda
Published: April 2022

Introduction: Non-surgical endodontic retreatment is highly dependent on the removal of previous root filling material, bacteria and necrotic tissue. Various techniques and instruments have been used for endodontic retreatment. Recently, the XP-endo Finisher has been introduced in endodontic treatment to clean highly complex morphologies and difficult to reach areas. Aims: a) To compare the effectiveness of XP-endo Finisher and ProTaper universal retreatment system with or without organic solvent in removing gutta-percha. b) To compare the amount of apically extruded debris between the groups. Methods: 24-human- extracted, single-rooted teeth were divided into three groups of 8. The groups were classified as follows: Group I: using a ProTaper universal retreatment system with chloroform. Group II: using a ProTaper universal retreatment system without chloroform. Group III: using a ProTaper universal retreatment system followed by XP-endo Finisher without chloroform. The apically extruded debris was collected during the retreatment and weighted. The roots were split longitudinally. The degree of dentinal tubules patency was evaluated by scanning electron microscopy. Results: The most intensely clear dentinal tubules were observed in group III, followed by group II and group I, respectively. Group I resulted in a debris extrusion, significantly less, as compared with the other groups (P < 0.05). While there was no notable difference between group II and group III (P > 0.05). Conclusion: Under the conditions of the present study, out of all the retreatment techniques that were used, the XPendo Finisher was the most effective in the removal of the gutta-percha in cervical, middle and apical thirds. The use of solvent during retreatment can decrease the amount of the apically extruded debris.
Study on Awareness and most convenient ways to select the Trading Account Application
Authors: Rabari Misvani , Gondaliya Dr. Vijay
Published: April 2022

In this study, the researcher was study on the awareness and most convenient ways to select the trading account application. In the recent time an investor has many choices towards opening the Demat/Trading account because there are many application s by which they can operate their account. The main objective of the study to know the factor inspiring investors to open Trading Account, to know the investors preference or criteria for selecting the trading account application. Review of literature which includes authorized work of various authors with conclusion, variable studies and interpretation In this study researcher used Descriptive Research design and Non –probability convenience sampling. The data has been collected through the questionnaire. Which includes demographic profile; close-ended questionnaire and multiple responses.124 respondents have filled the questionnaire. In the data analysis, researcher was applied simple percentage, frequency analysis and cross-tabulation between different variable. At last it can conclude that the company has to focus on the features of their application so that they can easily attract to investors. Some problems like hidden charges and non-dispatch of transaction statement which is faced by the investors in which the company should work on it. After all this company make most effective trading account application and easily satisfied their clients. Key Words: Trading account application, Convenient, Criteria, Awareness
Mekanisme Komitmen Afektif dalam Hubungan Dukungan Sosial dan Organizational Citizenship Behavior (OCB)
Authors: Sri Muni'ah
Published: April 2022

Penelitian ini dilaksanakan pada Sektor Publik Pemerintah Kabupaten Indragiri Hilir dengan tujuan untuk mengidentifikasi hubungan dari Dampak Person Environment Fit Terhadap Komitmen Afektif dan Dampak Person Environment Fit Terhadap OCB dan pengaruh Dampak OCB Terhadap Komitmen Afektif pada Pegawai Sekretariat Daerah Kabupaten Indragiri Hilir. Dalam hal ini jumlah Populasi dalam penelitian ini adalah Sebanyak 165 Orang Pegawai ASN Sekretariat Daerah Kabupaten Indragiri Hilir Provinsi Riau, ukuran sampel untuk SEM yang menggunakan model estimasi maximum likelihood estimation (MLE) adalah 100-200 sampel (Ghozali 2008). Metode pengumpulan data yang digunakan dalam penelitian ini adalah dengan menggunakan kuesioner atau angket serta Pengujian hipotesis dalam penelitian ini menggunakan SEM-PLS melalui software WarPLS 5.0. PLS merupakan analisis persamaan struktural (SEM) hasil pada penelitian ini membuktikan bahwa Person Environment Fit berpengaruh secara positif dan signifikan terhadap Komitmen Afektif, Person Environment Fit berpengaruh secara positif dan signifikan terhadap OCB dan Person Environment Fit berpengaruh secara positif dan signifikan terhadap OCB. Limitasi penelitian ini karena sedikitnya populasi yang diambil sehingga kurang mampu memberikan generalisasi terhadap hasil penelitian khususnya yang menggambarkan peran moderasi.
Mekanisme Kualitas Interaksi Dalam Hubungan Kepemimpinan Autentik Dengan Komitmen Afektif Pegawai
Authors: Syahporter Daud  , Agus Seswandi
Published: April 2022

Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh kepemimpinan autentik terhadap komitmen afektif pada Dinas Lingkungan Hidup dan Kebersihan (DLHK) Kab. Indragiri Hilir pengaruh kualitas interaksi terhadap komitmen afektif, pengaruh kepemimpinan autentik terhadap kualitas interaksi dan untuk mengetahui apakah hubungan antara kualitas interaksi memediasi terhadap kepemimpinan autentik dan komitmen afektif pada Dinas Lingkungan Hidup dan Kebersihan (DLHK) Kab. Indragiri Hilir. Sampel menggunakan teknik sampling jenuh karena jumlah populasi yang relative kecil. Sampel yang digunakan pada penelitian ini berjumlah73 orang. Analisa data penelitian diolah dengan menggunakan pendekatan Partial Least Square (PLS) untuk menganalisis data dan mengetahui hubungan antar konstruk. Hasil penelitian menunjukkan bahwa kepemimpinan autentik signifikan pengaruhnya terhadap komitmen afektif pada Dinas Lingkungan Hidup dan Kebersihan (DLHK) Kab. Indragiri Hilir. Kualitas interaksi tidak signifikan pengaruhnya terhadap komitmen afektif pegawai pada Dinas Lingkungan Hidup dan Kebersihan (DLHK) Kabupaten Indragiri Hilir. Kepemimpinan autentik signifikan pengaruhnya terhadap kualitas interaksi pegawai pada Dinas Lingkungan Hidup dan Kebersihan (DLHK) Kab. Indragiri Hilir dan tidak terdapat hubungan antara kualitas interaksi memediasi terhadap kepemimpinan autentik dan komitmen afektif pada Dinas Lingkungan Hidup dan Kebersihan (DLHK) Kab. Indragiri Hilir.
The Advantages and Disadvantages of Phytoestrogens
Authors: Sutrisno, M.D., Ph.D, REI
Published: April 2022

Phytoestrogens are plant-derived chemicals found in various foods, the most prominent in soy. Many health benefits are attributed to phytoestrogens, including a reduced incidence of osteoporosis, breast cancer, menopausal symptoms, and heart disease; however, many are also classified as endocrine disruptors, which can potentially create adverse health effects. As a result, whether phytoestrogens are good or hazardous to one's health has yet to be answered. The answer is likely complicated, and it could be influenced by factors, namely health, age, and the presence or absence of specific gut bacteria. Because worldwide consumption is continually expanding, clarity on this subject is required. On the other hand, phytoestrogens are frequently advertised as a natural alternative to estrogen replacement therapy and are included in various dietary supplements. Because phytoestrogens have molecular and cellular properties similar to those of artificial endocrine disruptors, such as bisphenol A (BPA), and are also weak estrogen agonists/antagonists, making them valuable models for general understanding of the biologic effects of endocrine disruptors 1–3.
PENGEMBANGAN FITUR PENGAJUAN POIN NON AKADEMIK MAHASISWA DI SISTEM AKADEMIK MAHASISWA STIKOM PGRI BANYUWANGI
Authors: Moh Oqi Setiawan  , Dwi Yulian  , Nur Ahmadi Indartono
Published: April 2022

STIKOM Banyuwangi merupakan salah satu sekolah tinggi yang memiliki banyak kegiatan non-akademik. Adanya UKM dan BEM dalam kampus ini belum baik apabila setiap angota dari UKM atau BEM sendiri tidak mendapatkan nilai Non-Akademik dari kampus secara tertulis. Dan dengan adanya program kerja tersebut  dimana  dalam  setiap  kegiatan  memiliki  angka  kredit  point  yang nantinya akan di perhitungan untuk memenuhi persyaratan pendaftaran yudisium.   Dikarenakan   perhitungan   masih   manual   maka   penulis   akan membantu mengembangkan fitur Penilaian Ekstrakulikuler Mahasiswa. Dimana dalam sistem ini nanti akan menentukan nilai angka/kredit point dan menampilkan jumlah point kegiatan. Dalam sistem ini yang menggunakan pengembangan HTML 5 dengan bahasa pemrograman PHP dan didukung dengan framework CSS Bootstrap v.3.3.5. dimana akan membuat tampilan sistem secara responsive untuk diakses di Smart phone, Tablet maupun Dekstop. Dan data yang dimasukkan dalam software aplikasi ini disimpan secara terpusat dengan menggunakan database MySQL. Sistem Informasi Penilaian Kegiatan Mahasiswa ini untuk menghitung dan   menentukan   nilai   point   sertifikat   yang   diperoleh   mahasiswa   ketika mengikuti kegiatan- kegiatanselama studi di kampus. Dengan adanya penilitian ini, bisa membuat aplikasi yang ada lebih berkembang. Dan memudahkan mahasiswa untuk upload file dan kategori poin non akademik. Dan dapat dengan mudah mengakses berapa total poin yang sudah mereka kumpulkan di system akademik STIKOM PGRI Banyuwangi.
Risks to the 340B Drug Pricing Program Related to Manufacturer Restrictions on Drug Availability
Authors: Knox Ryan P. , Kesselheim Aaron S. , Sarpatwari Ameet
Published: April 2022

This Viewpoint documents the history, value, and success of the 340B Pricing Program, which is under threat from pharmaceutical corporations’ withdrawal and from a pending Supreme Court decision and offers 2 legislative fixes to address the concerns raised by the pharmaceutical companies.
Acute Upper Airway Disease in Children With the Omicron (B.1.1.529) Variant of SARS-CoV-2—A Report From the US National COVID Cohort Collaborative
Authors: Martin Blake , DeWitt Peter E. , Russell Seth , Sanchez-Pinto L. Nelson , Haendel Melissa A. , Moffitt Richard , Bennett Tellen D.
Published: April 2022

This cohort study uses data from the US National COVID Cohort Collaborative to evaluate upper airway infections in children during the surge of the Omicron (B.1.1.529) variant of SARS-CoV-2 in the US.
LINC00667 regulates MPP+‐induced neuronal injury in Parkinson’s disease
Authors: Huo Xinlong , Wang Lisong , Shao Jiahui , Zhou Chenhang , Ying Xiaowei , Zhao Jinhua , Jin Xinchun
Published: April 2022

Objective

Parkinson’s disease (PD), also known as paralysis tremor, is a chronic disease of the central nervous system. It has been reported that hepatocyte nuclear factor 4 alpha (HNF4A) is upregulated in PD, but its specific function has not been well explored.

Methods

We established an in vitro PD model in SH‐SY5Y cells stimulated with 1‐methyl‐4‐phenylpyridinium (MPP+). Meanwhile, the effect of HNF4A on MPP+‐treated SH‐SY5Y cell behavior was monitored by functional assays. Mechanism assays were conducted to verify the relationship among LINC00667/miR‐34c‐5p/HNF4A. Rescue experiments validated the regulatory mechanism in PD model.

Results

The results revealed that depletion of HNF4A suppressed cell cytotoxicity and apoptosis caused by MPP+. Knockdown of HNF4A recovered MPP+‐stimulated oxidative stress and neuroinflammation. Mechanically, HNF4A was targeted and inhibited by miR‐34c‐5p. Furthermore, we found that LINC00667 positively modulated HNF4A expression via sequestering miR‐34c‐5p in MPP+‐stimulated SH‐SY5Y cells. Interestingly, the data indicated that HNF4A could transcriptionally activate LINC00667 expression. Rescue experiments presented that miR‐34c‐5p interference or HNF4A overexpression could mitigate the effects of LINC00667 knockdown on cell viability, cytotoxicity, cell apoptosis, oxidative stress, and neuroinflammation in MPP+‐treated SH‐SY5Y cells.

Conclusion

Our study first proved LINC00667, miR‐34c‐5p, and HNF4A constructed a positive feedback loop in MPP+‐treated SH‐SY5Y cells, enriching our understanding of PD.
Revealing the Nature of Melt Pool Boundaries in Additively Manufactured Stainless Steel by Nano‐Sized Modulation
Authors: Sommer Konstantin , Agudo Jácome Leonardo , Hesse René , Bettge Dirk
Published: April 2022

In the current study, the 3D nature of the melt pool boundaries (MPBs) in a 316 L austenitic steel additively manufactured by laser‐based powder bed fusion (L‐PBF) is investigated. The change of the cell growth direction and its relationship to the MPBs is investigated by transmission electron microscopy. A hitherto unreported modulated substructure with a periodicity of 21 nm is further discovered within the cell cores of the cellular substructure, which results from a partial transformation of the austenite, which is induced by a Ga+ focused ion beam. While the cell cores show the modulated substructure, cell boundaries do not. The diffraction pattern of the modulated substructure is exploited to show a thickness ≥200 nm for the MPB. At MPBs, the cell walls are suppressed, leading to continuously connecting cell cores across the MPB. This continuous MPB is described either as overlapping regions of cells of different growing directions when a new melt pool solidifies or as a narrow planar growth preceding the new melt pool.
Direct Ink Writing of Porous Ti6Al4V Alloys via UV Light Curing
Authors: Li Zebei , Yang Fang , Wang Haojie , Li Yanli , Chen Cunguang , Guo Zhimeng
Published: April 2022

Although 3D printing of titanium alloys is often obtained by laser fusion deposition, its cost is relatively high. In this study, one light‐curing‐assisted technique is designed to print porous Ti6Al4V alloys via direct ink writing (DIW). For printing, titanium alloy slurry with 45 vol% solid content is prepared based on 1,6‐hexanediol diacrylate monomer‐trimethylolpropane triacrylate monomer (HDDA‐TMPTA) photosensitive system. In such a case, the extruded filament was in situ cured under the action of UV light irradiation in the printing process. The printed lattice sample has good surface performance without the observation of a collapse. After sintering, the shrinkage percentage is around 16% in the horizontal direction and 19% in the vertical direction. Surface morphology does not change significantly. Through comparative tests, it is found that the sintered samples have good microstructure and mechanical properties. When the filling rate is 50%, the compressive strength could reach 604.7 MPa and the flexural strength is 106.8 MPa. The feasibility of this new printing method to prepare titanium alloy parts are confirmed.
Molecular Hinges Stabilize Formamidinium‐Based Perovskite Solar Cells with Compressive Strain
Authors: Shi Congbo , Song Qizhen , Wang Hao , Ma Sai , Wang Chenyue , Zhang Xiao , Dou Jie , Song Tinglu , Chen Pengwan , Zhou Huanping , Chen Yihua , Zhu Cheng , Bai Yang , Chen Qi
Published: April 2022

Formamidinium (FA)‐based lead triiodide have emerged as promising light‐harvesting materials for solar cells due to their intriguing optoelectronic properties. However, obstacles to commercialization remain regarding the primary intrinsic materials instability, wherein volatile organic components of FA+ cations are prone to escape under operational stressors. Herein, stabilizing FA‐based perovskite through toughening the interface with the symmetric molecule of 1,1′‐(Methylenedi‐4,1‐phenylene) bismaleimide (BMI) is reported. BMI with two maleimides can simultaneously bind with FA+ and/or undercoordinated Pb2+ through chemical bonding, which also compresses the resultant perovskite lattice. The chemical bonding and strain modulation synergistically not only passivate film defects, but also inhibit perovskite decomposition, thus significantly improving the intrinsic stability of perovskite films. As a result, the BMI‐modified perovskite solar cells (PSCs) show improved power conversion efficiency (PCE) from 21.4% to 22.7% and enhanced long‐term operational stability, maintaining 91.8% of the initial efficiency after 1000 h under continuous maximum power point tracking. The findings shed light on the synergetic effects of chemical interactions and physical regulations, which opens a new avenue for stable and efficient perovskite‐based optoelectronic devices.
Native Ligand Carbonization Renders Common Platinum Nanoparticles Highly Durable for Electrocatalytic Oxygen Reduction: Annealing Temperature Matters
Authors: Li Zhicheng , Zou Jinxiang , Xi Xiangyun , Fan Pengshuo , Zhang Yi , Peng Ye , Banham Dustin , Yang Dong , Dong Angang
Published: April 2022

Current protocols for synthesizing monodisperse platinum (Pt) nanoparticles typically involve the use of hydrocarbon molecules as surface‐capping ligands. Using Pt nanoparticles as catalysts for the oxygen reduction reaction (ORR), however, these ligands must be removed to expose surface sites. Here, highly durable ORR catalysts are realized without ligand removal; instead, the native ligands are converted into ultrathin, conformal graphitic shells by simple thermal annealing. Strikingly, the annealing temperature is a critical factor dictating the ORR performance of Pt catalysts. Pt nanoparticles treated at 500 °C show a very poor ORR activity, whereas those annealed at 700 °C become highly active along with exceptional stability. In‐depth characterization reveals that thermal treatment from 500 to 700 °C gradually opens up the porosity in carbon shells through graphitization. Importantly, such graphitic‐shell‐coated Pt catalysts exhibit a superior ORR stability, largely retaining the activity after 20 000 cycles in a membrane electrode assembly. Moreover, this ligand carbonization strategy can be extended to modify commercial Pt/C catalysts with substantially enhanced stability. This work demonstrates the feasibility of boosting the ORR performance of common Pt nanoparticles by harnessing the native surface ligands, offering a robust approach of designing highly durable catalysts for proton‐exchange‐membrane fuel cells.
Silk Fibroin‐Based Flexible Organic Light‐Emitting Diode with High Light Extraction Efficiency
Authors: Chen Wei , Xu Chuan , Kong Lingqing , Liu Xiang‐Yang , Zhang Xingye , Lin Naibo , Ouyang Xinhua
Published: April 2022

It is an essential issue for the efficiency of flexible organic light‐emitting diodes (OLEDs) to be improved in display and lighting applications. Herein, the use of silk fibroin (SF) as a flexible OLED substrate with enhanced light extraction efficiency (LEE) is reported. Regenerated SF is prepared via a casting method and then coated with conductive indium tin oxide (ITO) via magnetron sputtering. SF‐based flexible OLED outperforms its reference device in terms of turn‐on voltage, peak brightness, and LEE, where glass and polyethylene terephthalate are used as rigid and flexible substrates, respectively. The improved device performance can be ascribed to the low refractive index of SF and its lower surface roughness and more matched energy levels compared to those of other substrates, resulting in a high LEE. Notably, a molecular dipole layer can be formed between the interface of ITO and SF. The dipole moment pointing to the ITO surface effectively changes the ITO work function and reduces the potential barrier height for hole transfer. The work provides new ideas for constructing high‐performance OLEDs on biomass‐based substrates with excellent flexibilities and high LEEs.
Occupational health within the bounds of primary care: Factors shaping the health of Latina/o immigrant workers in federally qualified health centers
Authors: Torres Ivy R. , Shklanko Sarah , Haq Cynthia , LeBrón Alana M.W.
Published: April 2022

Background

Many workers seek care for work‐related medical conditions in primary care settings. Additionally, occupational medicine training is not consistently addressed in primary care professional training. These patterns raise concerns about the health outcomes of low‐wage Latina/o immigrant workers who make use of primary care settings to obtain care for work‐related injuries and illnesses. The objective of this qualitative study was to investigate how primary care clinicians assessed and addressed the role of occupational exposures on the health and well‐being of Latina/o immigrant workers.

Methods

We conducted semistructured in‐depth interviews with 17 primary care clinicians (physicians, resident physicians, and nurse practitioners) employed in an urban federally qualified health center (FQHC) with two sites located in Orange County, CA.

Results

Using a constructivist grounded theory approach, we determined that primary care clinicians had a general understanding that employment influenced the health and well‐being of their Latina/o immigrant patients. Clinicians delivered care to Latina/o immigrant workers who feared reporting their injury to their employer and to Latina/o immigrants whose workers' compensation claim was terminated before making a full recovery. Clinicians were responsive to patients' work‐related concerns and leveraged the resources available within the FQHC. Although some clinicians offered suggestions to improve occupational health in the FQHC, a few clinicians raised concerns about the feasibility of additional health screenings and clinic‐based interventions, and pointed to the importance of interventions outside of the healthcare system.

Conclusion

This study underscores the complexities of addressing occupational health concerns in urban FQHCs.
Loeys–Dietz syndrome caused by 1q41 deletion including TGFB2 is associated with a neurodevelopmental phenotype
Authors: Fry Deanna , Groepper Daniel , MacCarrick Gretchen , Demo Erin M. , Thomas Matthew J. , Wilkes Margaret J. , Lyons Michael J. , Tucker Megan E. , Steding Catherine , Fleischer Julie
Published: April 2022

Loeys–Dietz syndrome (LDS) is a connective tissue disorder that commonly results in a dilated aorta, aneurysms, joint laxity, craniosynostosis, and soft skin that bruises easily. Neurodevelopmental abnormalities are uncommon in LDS. Two previous reports present a total of four patients with LDS due to pure 1q41 deletions involving TGFB2 (Gaspar et al., American Journal of Medical Genetics Part A, 2017, 173, 2289–2292; Lindsay et al., Nature Genetics, 2012, 44, 922–927). The current report describes an additional five patients with similar deletions. Seven of the nine patients present with some degree of hypotonia and gross motor delay, and three of the nine present with speech delay and/or intellectual disability (ID). The smallest deletion common to all patients is a 785 kb locus that contains two genes: RRP15 and TGFB2. Previous studies report that TGFB2 knockout mice exhibit severe perinatal anomalies (Sanford et al., Development, 1997, 124, 2659–2670) and TGFB2 is expressed in the embryonic mouse hindbrain floor (Chleilat et al., Frontiers in Cellular Neuroscience, 2019, 13). The deletion of TGFB2 may be associated with a neurodevelopmental phenotype with incomplete penetrance and variable expression.
Silicon‐containing polyarylacetylene aerogel with heat resistance and ablative property for high‐temperature insulation
Authors: Zhao Chuanqing , Chen Fan , Dong Sensen , Liu Xiaoyun , Qi Huimin , Deng Shifeng
Published: April 2022

Owing to the high porosity and low thermal conductivity of organic aerogels, they have been widely used to develop lightweight heat insulation materials. However, their applications in high‐temperature environments such as in aerospace applications are usually limited by the heat resistance or ablative property of the organic matrix. In this study, we prepared a novel organic aerogel for high‐temperature insulation by the sol–gel method and freeze‐drying. The matrix is the thermosetting silicon‐containing polyarylacetylene (PSA) resin with excellent comprehensive properties, namely, high heat stability, low volatile component content, and high‐temperature ceramic performance. The obtained PSA aerogel retains the heat resistance (Td5 = 634.8°C) and ablative properties (Yr800 = 92.6%) of the PSA resin, and the internal regular macropores and high porosity (70%) result in an extremely low weight (0.1200 g cm−3), low thermal conductivity (0.039 W m−1 K−1)), and efficient heat insulation. Thus, this is an ideal material for high‐temperature insulation in the aerospace field.
Development of aptamer‐based ELISA method for d‐dimer detection
Authors: Yildirim‐Tirgil Nimet
Published: April 2022

This study developed an aptamer‐based enzyme‐linked immunosorbent assay (ELISA) system for sensitive detection of the
d
‐dimer molecule, which is significantly elevated in several severe diseases. Aptamers are known to have advantages, such as longer stability and usability at different temperatures and in different complex samples, over antibodies, which are generally used in traditional ELISA methods. In the present work, the aptamer‐based ELISA system was capable of quantitatively determining in a wide range (100 ng/ml─10 μg/ml) and remain stable for a couple of months even under ordinary room conditions. Validation of the developed system was evaluated by spiked human serum samples with high accuracy. With more comprehensive project steps, the developed aptamer‐based ELISA system could be transformed into a platform that offers a sensitive, portable, and easy‐to‐use tool for analyzing
d
‐dimer molecules.
All Redox‐Active 2D MXene and 0D Phosphomolybdic Acid Nanoclusters‐Anchored Polypyrrole Nanotubes for High‐Performance Aqueous Hybrid Supercapacitors
Authors: Stephanie Ruth , Patil Swati J. , Chodankar Nilesh R. , Huh Yun Suk , Han Young‐Kyu , Park Tae Jung
Published: April 2022

The construction of a hybrid supercapacitor (HSC) with 2D Ti3C2Tx MXene anode is restricted by the scarcity of promising cathode materials that can demonstrate the superior electrochemical features in protic electrolytes. To circumvent this issue, we demonstrate an innovative high‐performance HSC cell in a protic electrolyte by combining a redox‐active 0D phosphomolybdic acid (PMo12) nanoclusters‐anchored polypyrrole nanotubes (PMo12/PPyNT) cathode against the pseudocapacitive Ti3C2Tx MXene anode. Decorating PMo12, a Keggin‐type polyoxometalates material known for their high redox activities on polypyrrole nanotubes (PPyNT) resulting in a nanocomposite that matches the electrochemical performance of MXene in a protic electrolyte so that a high‐performance HSC cell can be acquired. The gathered PMo12/PPyNT//MXene HSC cell delivers the specific energy (36.1 Wh/kg) and specific power (6.66 kW/kg) superior to the state‐of‐the‐art MXene‐based supercapacitor (SC) cells. The cell also exhibits impressive coulombic efficiencies over various current densities and adequate stability over 5000 charge‐discharge cycles. These results show that combining polyoxomolybdate‐based cathode materials against the MXene anode can overcome the boundaries associated with the existing HSC cells.
Successful hemostasis by percutaneous transhepatic cyanoacrylate injection for hepatic artery pseudoaneurysm causing hemobilia
Authors: Prasoppokakorn Thaninee , Kulpatcharapong Santi , Plai‐Dum Suppawatsa , Piyachaturawat Panida , Ridtitid Wiriyaporn , Charoenvisal Ching , Rerknimitr Rungsun
Published: April 2022

A 73‐year‐old man, post‐liver transplantation, was scheduled for ERCP to evaluate anastomotic biliary stricture. The patient developed massive bleeding from hepatic artery pseudoaneurysm. Angiography via femoral artery could not identified feeding artery of the pseudoaneurysm. Thus, trans‐abdominal ultrasonography was performed and percutaneous transhepatic glue embolization successfully.
Successful treatment of relapsed chronic lymphocytic leukemia with venetoclax in a patient with severe chronic kidney disease
Authors: Sugiura Hiroyuki , Sezaki Nobuo , Ishikawa Tatsunori , Kuroi Taiga , Okamoto Sachiyo , Nomura Naho , Masunari Taro , Nakasako Yukio , Kiguchi Toru , Tanimoto Mitsune
Published: April 2022

Venetoclax is a promising new drug for relapsed or refractory chronic lymphocytic leukemia (CLL). However, venetoclax use had not been reported in severe chronic kidney disease (CKD) patients. We report the first case of relapsed CLL in a severe CKD patient that was successfully treated with venetoclax.
Doctoral students’ publication and editorial feedback experiences: A phenomenological inquiry
Authors: Lee Injung , Duys David K. , Wood Susannah M.
Published: April 2022

We explored 12 doctoral students’ experiences with research and publication, including the editorial feedback process. Findings highlight the university's research climate/culture, the training strategies employed, critical learning experiences, support and resources, and doctoral students’ meaning‐making of their experience. Implications for mentoring, training conditions, and professional writing orientation strategies are provided.
An FTIR Study of the Electrooxidation of C2 and C3 Alcohols on Carbon‐Supported PdxRhy in Alkaline Medium**
Authors: Moreira Thamyres F. M. , Andrade Adalgisa R. , Boniface Kokoh K. , Morais Cláudia , Napporn Teko W. , Olivi Paulo
Published: April 2022

We have investigated the promoting effect of Rh addition to Pd‐based materials in the electrooxidation of ethanol and glycerol. Physicochemical characterizations (XRD, EDX, TEM, and XPS) of the PdxRhy/C materials, prepared by bromide anion exchange (BAE), showed that the experimental bimetallic compositions were close to the targeted ones. PdxRhy/C particle sizes ranged from 2.2 to 3.8 nm. The ethanol oxidation reaction (EOR) on the PdxRhy/C catalysts yielded four times larger carbonate (CO32−) amount. As for the glycerol oxidation reaction (GOR), the onset potential on the Pd50Rh50/C catalyst occurred at lower potentials. Chromatographic analysis combined with in situ Fourier transform infrared (FTIR) spectroscopy showed that GOR on the Pd50Rh50/C catalyst selectively and quantitatively produced glycerate and tartronate. The outstanding ability of the Pd50Rh50/C catalyst toward EOR and GOR was correlated to the electronic effect expressed by a negative potential shift (200 mV) and the 47 % alloying degree in the Pd50Rh50/C structure.
Composite bias‐reduced Lp‐quantile‐based estimators of extreme quantiles and expectiles
Authors: Stupfler Gilles , Usseglio‐Carleve Antoine
Published: April 2022

Quantiles are a fundamental concept in extreme value theory. They can be obtained from a minimization framework using an asymmetric absolute error loss criterion. The companion notion of expectiles, based on asymmetric squared rather than asymmetric absolute error loss minimization, has received substantial attention from the fields of actuarial science, finance, and econometrics over the last decade. Quantiles and expectiles can be embedded in a common framework of ‐quantiles, whose extreme value properties have been explored very recently. Although this generalized notion of quantiles has shown potential for the estimation of extreme quantiles and expectiles, available estimators remain quite difficult to use: they suffer from substantial bias, and the question of the choice of the tuning parameter remains open. In this article, we work in a context of heavy tails and construct composite bias‐reduced estimators of extreme quantiles and expectiles based on ‐quantiles. We provide a discussion of the data‐driven choice of and of the anchor ‐quantile level in practice. The proposed methodology is compared with existing approaches on simulated data and real data.
PROTOCOL: Conflict of interest issues when engaging stakeholders in health and healthcare guideline development: a systematic review
Authors: Khabsa Joanne , Petkovic Jennifer , Riddle Alison , Lytvyn Lyubov , Magwood Olivia , Atwere Pearl , Campbell Pauline , Katikireddi Srinivasa V. , Merner Bronwen , Nasser Mona , Chang Stephanie , Jaramillo Garcia Alejandra , Limburg Heather , Guise Jeanne‐Marie , Tugwell Peter , Akl Elie A.
Published: April 2022

This is the protocol for a Campbell systematic review. The overall objective of this study is to gather and summarize the existing literature on conflict of interest issues when engaging stakeholders in guideline development.
Structural Considerations for Building Synthetic Glycoconjugates as Inhibitors for Pseudomonas aeruginosa Lectins
Authors: Wojtczak Karolina , Byrne Joseph P.
Published: April 2022

Pseudomonas aeruginosa is a pathogenic bacterium, responsible for a large portion of nosocomial infections globally and designated as critical priority by the World Health Organisation. Its characteristic carbohydrate‐binding proteins LecA and LecB, which play a role in biofilm‐formation and lung‐infection, can be targeted by glycoconjugates. Here we review the wide range of inhibitors for these proteins (136 references), highlighting structural features and which impact binding affinity and/or therapeutic effects, including carbohydrate selection; linker length and rigidity; and scaffold topology, particularly for multivalent candidates. We also discuss emerging therapeutic strategies, which build on targeting of LecA and LecB, such as anti‐biofilm activity, anti‐adhesion and drug‐delivery, with promising prospects for medicinal chemistry.
Immune Checkpoint Inhibitors and Venous Thromboembolism: An Analysis of the WHO Pharmacovigilance Database
Authors: Allouchery Marion , Beuvon Clément , Pérault‐Pochat Marie‐Christine , Roblot Pascal , Puyade Mathieu , Martin Mickaël
Published: April 2022

Data on venous thromboembolic events (VTEs) in patients receiving immune checkpoint inhibitors (ICIs) are scarce and conflicting. This study investigated the risk of reporting VTEs associated with ICIs in comparison with all other anticancer drugs. The World Health Organization pharmacovigilance database (VigiBase), comprising >30 million individual case safety reports, was queried. All reports on patients with cancer, involving at least one anticancer drug as a suspect or interacting drug and registered from January 1, 2008, to May 31, 2021, were included. The association between ICIs and the risk of reporting VTEs was estimated using the reporting odds ratio (ROR) as a measure of disproportionality with all other anticancer drugs as comparators. RORs were estimated as crude and adjusted RORs for age, sex, and other medications (excluding anticancer drugs) associated with risk of VTEs. Among 1,196 patients experiencing VTEs after ICI treatment, the median age was 65 years and 57.6% were men. Anti‐PD‐1 agents (62.5%) were the most frequently reported. ICIs were not associated with higher reporting of VTEs when compared with other anticancer drugs (crude ROR 0.63, 95% confidence interval (CI) 0.60 to 0.67 and adjusted ROR 0.70, 95% CI 0.65–0.74). No signal of disproportionate reporting was found when considering each class of ICIs. In conclusion, ICIs were not associated with higher reporting of VTEs, in comparison with all other anticancer drugs in a large‐scale pharmacovigilance database. Owing to the limitations inherent to pharmacovigilance studies, prospective studies, including an adequate comparison group, are needed to assess the risk of VTEs in ICI‐treated patients.