bluuebunny/crossref_metadata_2025 huggingface dataset:
Cecilio Eseverri Chaverri: semblanza del enfermero humanista
Authors: Amezcua Manuel , Martínez Rodríguez Laura
Published: February 2023

Cecilio Eseverri Chaverri es enfermero, trabajador social y teólogo. En su dilatada actividad profesional ha alternado el cuidado a los pacientes con la administración de servicios de enfermería y una intensa actividad docente, incluso con la creación de una importante escuela de gerencia en Barcelona. En su trayectoria destaca la gran aportación que ha realizado a la historia de la Enfermería, siendo autor de numerosos artículos y varios libros que son de obligada lectura para conocer el verdadero pasado de nuestra profesión. El día 21 de octubre de 2022, el grupo Oseira de historia de la Enfermería, adscrito a la Fundación Index, en colaboración con el Colegio de Enfermería de Granada, le tributaron un homenaje a su trayectoria como enfermero y como historiador de la Enfermería, cuyo discurso de presentación se reproduce aquí. Como complemento se aporta el videoclip realizado a partir de los testimonios de historiadores de la Enfermería en España que quisieron adherirse a este homenaje.
Về công trình Văn học Việt Nam hiện đại (1945 - 1960) của Giáo sư Nhà giáo nhân dân Hoàng Như Mai
Authors: Nguyen A Say
Published: February 2023

Hoàng Như Mai có nhiều đóng góp trong lĩnh vực giáo dục, văn học, nghệ thuật. Trong lĩnh vực nghiên cứu văn học, Hoàng Như Mai có nhiều bài viết về các tác giả, tác phẩm nổi bật của nền Văn học Việt Nam. Trong đó, nổi bật là công trình có tính chất gợi mở, mở đầu: “Văn học Việt Nam hiện đại (1945 - 1960)” do Nhà xuất bản Giáo dục xuất bản năm 1961. Bài viết phân tích giá trị của công trình nghiên cứu văn học có tính chất mở đầu ở các phương diện về bố cục, phạm vi nghiên cứu, nội dung nghiên cứu; đồng thời chỉ ra một số ưu điểm, hạn chế trong nghiên cứu văn học của Hoàng Như Mai qua công trình trên.
Varlık, Bilgi ve Marifet
Authors: Önalan Gökhan Oruç
Published: February 2023

İnsanın yaratılışı, beden ve ruh çerçevesinde iki kısımdır. Hicr Suresi 26. ayetinde işaret edildiği üzere beden, Allah Teâlâ’nın yaratma sıfatının bir eseri ve tecellisi olarak topraktan başlayarak devam eden fiziksel ve biyolojik değişim sürecindedir. Beden, ihtiyaçlara muhtaç olduğu kadar ruh da manevî kudrete o derece muhtaçtır. İnsan, kendisini yaratan İlahî iradeyi tanımak ve bilmek, bu âlemin yaratılış gerekçesini kavramak ve kendisinin dünya hayatındaki yaratılış amacını öğrenmek ister. Tüm insanlığa gönderilen, hükmü çağları aşarak kıyamete kadar sürecek, ilk insan ve ilk Peygamber Hz. Âdem (as.)’ın kullara tebliğ ettiği Tevhîd dini ve sonrasında gelen semavî dinlerin devamı (hükümlerini ortadan kaldıran), Allah Teâlâ’nın katındaki tek din İslâm’dır. Miladî 610 yılında Cebrâil (as.), Peygamber Efendimiz Hz. Muhammed (sas.)’e vazifesini tebliğ etmiş böylece Resûlullah (sas.), Allah Teâlâ tarafından son ve en büyük yol göstericimiz olarak görevlendirilmiştir. Dinin itikadî, amelî ve ahlâkî hükümlerinin amacı ise (makāsıdü’ş-şerîa) kulların dünya ve âhiret mutluluğuna erişmesi, bütün davranışlarında Allah Teâlâ’nın rızâsını kazanabilmesini sağlamaktır. Fâtır Suresi’nin 10. ayetinde, “güzel sözler – kelimu’t tayyib” ifadesi ilmi kastetmekte böylece amelin, ilmin tamamlayıcısı mahiyetinde olduğu gerçeğine dikkat çekilmektedir. O halde, makāsıdü’ş-şerîa’nın yolu ilim ve amelden geçmektedir ki ilim, amellerin de en faziletli olanıdır. İlmin amacı kendisi ile amel etmektir.
Inclusão da pessoa com deficiência no mercado de trabalho no município de Floriano-PI
Authors: Sousa Francisca Sobral de , Oliveira Maria do Rosário Alves de , Silva Marijany Costa de Miranda
Published: February 2023

Este estudo pretende mostrar a inclusão de pessoas com deficiência no quadro das maiores empresas no município de Floriano-PI. A escolha desse tema surgiu pela curiosidade de saber se as grandes empresas, citadas, do município de Floriano-Pi, estão cumprindo com a responsabilidade, e se estão de acordo com a Política Nacional da Pessoa Com Deficiência. O objetivo geral pretende mostrar o número de pessoas com deficiência que atuam no mercado de trabalho em algumas empresas privadas do município de Floriano-PI, identificando a quantidade geral de funcionários; apresentar a importância da inclusão da pessoa com deficiência no mercado de trabalho e mostrar se as empresas pesquisadas cumprem o que estabelece a lei das cotas (Lei Nº 8.213/91). Trata-se de uma pesquisa qualitativa – exploratória, de natureza bibliográfica e de campo. Tendo como instrumento quantitativo, uma pesquisa realizada no período de janeiro a dezembro de 2021 com atualização em outubro de 2022, nos bancos de dados dos sistemas das empresa denominadas nos gráficos como X, Y e Z. Espera-se que este estudo contribua para o incentivo de inclusão das pessoas com deficiência no mercado de trabalho, como também da abertura de vagas em outras empresas para essa população.
Super bactéria: Os principais mecanismos e medicamentos de resistência bacteriana
Authors: Ribeiro Everllainy De Carvalho Romão , Santos Mylena De Oliveira , Sousa Georgette Carnib de
Published: February 2023

O desenvolvimento de resistência bacteriana aos antibióticos é um fenômeno natural resultante da pressão seletiva exercida pelo uso deste medicamento, mas, que tem sofrido uma expansão muito acelerada devido à utilização inadequada destes fármacos, existindo uma correlação muito clara entre um maior consumo de antibióticos e níveis mais elevados de resistência microbiana. O estudo teve como objetivos analisar os principais mecanismos da resistência bacteriana frente aos antimicrobianos; e descrever quais medicamentos que apresentam resistência bacteriana na literatura pesquisada. Trata-se de uma revisão da literatura que foi desenvolvida entre os meses de agosto a outubro de 2019. Foram selecionados os artigos disponíveis na Biblioteca Eletrônica de dados do Scientific Electronic Library Online (SciELO), na base de dados eletrônica da Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e da Medical Literature Analysisand Retrieval System Online (MEDLINE), através da Biblioteca Virtual em Saúde (BVS). Utilizaram-se como critérios de inclusão artigos científicos que responderam à questão norteadora, que estivessem na língua portuguesa, inglesa e espanhola, disponíveis na íntegra e gratuitamente nas bases de dados selecionadas no período de 2013 a 2019. Conclui-se que os principais mecanismos de resistência bacteriana apontados na literatura é a concentração inibitória mínima – CIMS, produção de enzima ß-lactamases, mutação genética, formação de biofilmes e consórcios sensor de quorum, presença de enzima NDM-1 e de enzimas modificadoras de aminoglicosídeos. Com relação aos medicamentos resistentes a bactérias pode-se apontar ciprofloxacina, penicilina, clindamicina, eritromicina, trimetroprina, sulfonamidas, carbapenêmicos, amoxicilina e meticilina.
Projeto desenvolvimento de comunidade: Diagnóstico Social do Bairro Rede Nova
Authors: Silva Marijany Costa de Miranda , Barros Glauce , Barbosa Joseane , Alves Michelle Da Silva , Araújo Vitória Maria Ferreira de , Sousa Carlicélia Pereira de , Sá Evelina Miranda de , Celestino Renata Maria
Published: February 2023

A finalidade do projeto é oferecer aos moradores do Bairro Rede Nova um documento que destaca suas peculiaridades e características, sua forma de desenvolvimento em todos os setores, bem como as necessidades de melhorias para a comunidade desde a infraestrutura, oferta de produtos e equipamentos públicos. Sabemos que quando existem as demandas, estas podem ser transformadas em projeto de lei, passando assim a ser incorporadas ao poder municipal, a fim de que haja de fato a transformação do bairro em todos os sentidos, para a melhoria da qualidade de vida e convívio social de todos da comunidade Rede Nova.
Práticas Educacionais Inclusivas no contexto da formação continuada: revisão integrativa de estudos no período de 2011 a 2021
Authors: Antunes Alexssandro Cardoso , Yared Yalin Brizola
Published: February 2023

Este artigo refere-se a uma pesquisa realizada no âmbito de um coletivo de um Programa de Pós-Graduação em Educação de uma universidade privada do Sul do Brasil e desenvolvida na disciplina de Formação de Professores, ofertada por aulas presenciais em 2022/A. Propôs-se identificar e analisar as práticas educacionais inclusivas utilizadas no campo da formação continuada, relatadas nos artigos científicos publicados em periódicos on-line na base de dados da SciELO, no período de 2011 a 2021. Para tanto, optou-se pelo método da revisão integrativa, que foi dividida em três etapas específicas visando o rigor do andamento da pesquisa: definição do tema e a pergunta de pesquisa, definição dos critérios de inclusão, exclusão e procedimentos de busca na base de dados da SciELO, incluso nesta fase a categorização dos artigos e análise e interpretação dos resultados. Os dados obtidos nos seis artigos possibilitaram a apresentação sintética dos resultados obtidos à luz das práticas educacionais e a formação continuada no contexto da inclusão e a legislação brasileira. A análise revelou a ausência de pesquisas no que se refere às práticas educacionais inclusivas e (in)exitosas do ponto de vista dos estudantes que necessitam de atendimento educacional especializado. Constata-se ainda, a partir da análise dos artigos publicados na referida base de dados, a carência de cursos de formação continuada por meio de práticas educacionais no âmbito da inclusão. Portanto, a formação colocada à disposição do professor é unidirecional na relação do educador com o educando, contribuindo moderadamente para o enriquecimento da educação inclusiva.
Evaluation of the Color Adjustment Potential of Single-Shade Composite Resin in Primary Teeth
Authors: Kim Yongsoon , Park Howon , Lee Juhyun , Kim Haeni
Published: February 2023

Restoring composite resins with the optimal shades for all primary teeth is a great challenge for pediatric dentists. A newly developed single-shade composite resin can exhibit a color similar to that of the surrounding tooth structure based on the structural color phenomenon. This study aims to evaluate the color adjustment potential (CAP) of a single-shade composite resin compared to conventional multi-shade composite resins in primary teeth. A single-shade composite resin and two conventional multi-shade composite resins were included in this study. Two types of specimens, a single specimen and a dual specimen, were evaluated. For single specimens, duplications of the primary second molar denture teeth were made using experimental composite resins. For dual specimens, cavities were prepared on the buccal surfaces of extracted primary second molars and restored with experimental composite resins. The L*, a*, and b* values were measured using a colorimeter for the extracted teeth and specimens. The mean ΔEab* values for single and dual specimens and CAP were calculated. Bonferroni post-hoc analysis was performed to confirm the statistical significance between the ΔEab* and CAP values of the experimental resins. Among the single specimens, the single-shade composite resin showed significantly higher ΔESingle compared to other composite resins (p < 0.0167). There was no significant difference between ΔEDual for all experimental resins. The single-shade composite resin showed highest CAP compared to other multi-shade composite resins. A single-shade composite resin exhibited the most prominent color adaptability compared to other conventional multi-shade composite resins for primary second molars. A single-shade composite resin can simplify shade matching and provide esthetic outcomes for the restoration of primary second molars.
Bæredygtighedsbegrebets betydning, etik og etikdidaktik
Authors: Kristensen Lisa Rygaard Frost
Published: February 2023

[DK]Bæredygtighed er et begreb, der besidder en enorm sproglig vidde og bruges i så mange kontekster, at det kan være svært at få greb om, hvad begrebet betyder. Begrebet kan opfattes som en allestedsnærværende flydende betegner, men er begrebet bare tomt eller er det muligt at indkredse noget, der går på tværs af begrebets brugsområder? Med baggrund i en sprogfilosofisk begrebsanalyse bidrager denne artikel først og fremmest med en udlægning af begrebets vidde samt en samlende grundforståelse af bæredygtighed, som i særdeleshed knytter sig til etik. I indkredsningen af bæredygtighedsbegrebets etik betones det, at det er særligt fremtrædende i den etiske argumentation og begrundelse for bæredygtighed, at vi bør tage et etisk hensyn til noget, vi i en eller anden forstand er på afstand af (fjernhedsetik).Det tematiseres derefter, hvordan man kan arbejde med bæredygtighedsbegrebets (fjernheds)etik i skolen og i den forbindelse præsenteres et bud på bæredygtighedsbegrebets etikdidaktik. Dette eksemplificeres i forhold til undervisningsfaget engelsk. Det teoretiske grundlag for denne udlægning af, hvordan man kan facilitere (fjernheds)etiske bæredygtighedsrefleksioner, knytter primært an til kulturdidaktik, interkulturel læring samt forsknings- og praksisfeltet ’filosofi med børn’.

[UK]Sustainability is a concept that possesses linguistic width and is used in so many contexts that it can be hard to grasp what it actually means. Sustainability may be perceived as an all-encompassing, empty signifier. But is it just an empty concept, or is it possible to capture a certain core quality across the concept’s multifaceted use? Based on a conceptual analysis, which draws on philosophy of language, this article will first and foremost present a basic understanding of sustainability, which promotes ethics as a dominant feature. In the ethical argumentation for sustainability, it is a central point that we should (also) take responsibility for that which and those whom we are at a distance of. Finally, this article thematizes how you may work with sustainability ethics in school. More specifically, it is exemplified how the didactics of sustainability ethics may look in the subject English in the Danish folkeskole. The theoretical foundation behind this perspective is intercultural learning, intercultural education, and philosophy for children.
L’évaluation des pupilles : un incontournable pour la pratique infirmière à la salle d’urgence
Authors: Lapierre Alexandra , Tanguay Nicolas , Hébert Caroline , Williamson David , Arbour Caroline
Published: February 2023

L’examen neurologique est un aspect important de la pratique infirmière en soins critiques. Au sein de cet examen, l’évaluation des pupilles peut fournir des informations vitales chez la personne gravement malade. À la salle d’urgence spécifiquement, les infirmier.ères jouent un rôle déterminant dans l’identification de changements subtils au niveau de la taille, la symétrie, la réactivité pupillaire ou tout autre signe de détérioration neurologique chez la personne nouvellement admise. En dépit de l’importance de l’évaluation des pupilles à la salle d’urgence, il n’existe actuellement aucune norme pour guider cette pratique au sein de la profession infirmière. Le but de cet article est de décrire les composantes essentielles de l’évaluation des pupilles à la salle d’urgence ainsi que les facteurs et troubles neurologiques pouvant l’influencer afin d’outiller les infirmier.ères à l’égard de cette pratique.
HEALTH DISPARITIES, SOCIAL DETERMINANTS OF HEALTH, AND SYSTEMIC ANTI-BLACK RACISM DURING COVID-19: A CALL TO ACTION FOR SOCIAL WORK
Authors: Massaquoi Notisha , Ashcroft Rachelle , Adamson Keith
Published: February 2023

Systemic anti-Black racism is deeply rooted in the social, political, economic, ontological, and epistemological foundations of Canadian society. Driven by our code of ethics and the most recent call to reckon with anti-Black racism in society, the social work profession’s advocacy agenda requires reconceptualization to eradicate anti-Black racism and the creation of equitable environments within which Black communities can thrive. This article examines the anti-Black racism exhibited during the COVID-19 pandemic through the lens of health equity and health disparity. The interplay between health disparities, social determinants of health, and systemic anti-Black racism is highlighted and the urgency for social workers to respond to the causes of poor Black health outcomes is emphasized. Social workers are called upon to engage in a more intentional framework of Black health equity, which includes a practice that ensures the well-being and survival of Black people and their communities. The authors conclude that for the social work profession to reach its full potential, it must recognize and use its distinctive qualities to eradicate anti-Black racism.
Orchestrating a New Path for Multiple Sclerosis: Achieving Physical, Cognitive, and Emotional Rehabilitation Goals Through Physical and Music Therapy
Authors: Weigel Megan , Hutchinson Brian , Magee Wendy L. , Leong Kevin , Sweitzer Tom , Weiss Jamie L. , Su Wendy , Fleming Renée
Published: February 2023

BACKGROUND

Interdisciplinary therapies for the management of people with multiple sclerosis (MS) are underappreciated. There is an urgent need to introduce music therapy (MT), either alone or in combination with physical therapy (PT), into clinical practice to achieve synergy with disease-modifying therapies. A holistic approach to rehabilitation for people with MS may mitigate symptoms and reduce polypharmacy, potentially lowering health care costs.

RESULTS

As MS progresses, patients experience a range of worsening symptoms, and many develop psychosocial comorbidities. As disease-modifying therapies delay disability progression, nonpharmacologic treatments become increasingly important. The main aim of PT is to improve or maintain patients’ functional mobility, strength, and flexibility. Because it targets multiple functions, MT can help improve functional and psychosocial domains and may be a valuable intervention to help patients achieve the physical, cognitive, and emotional goals of PT. Exploratory studies showed that MT, alone or in combination with PT, can lead to functional improvements in mobility, balance, gait, and fatigue. Similar to PT, MT also has benefits in improving fine motor skills, cognition, learning, and memory and in providing emotional support.

CONCLUSIONS

Both MT and PT have the potential to improve overall well-being and health-related quality of life in physically active patients with MS, and MT can provide added emotional support for those who are less able to engage in physical activity. However, MT is not typically a part of standard of care, and PT visits are limited. Nevertheless, interdisciplinary therapies should be incorporated into clinical practice.
El árbol en medio de la tierra: una traducción al náhuatl del "Monte Calvario" de Antonio de Guevara
Authors: Sánchez Aguilera Mario Alberto
Published: February 2023

Este trabajo da a conocer la primera y, tal vez la única, traducción al náhuatl de un fragmento del "Libro llamado Monte Calvario", obra del célebre franciscano Antonio de Guevara, publicada en 1545. Asimismo, explora la manera en que un grupo de letrados indígenas, que se desempeñaron como traductores y amanuenses durante el siglo XVI, hallaron en uno de los capítulos de esta obra guevariana un referente cultural tan semejante y afín al pensamiento indígena que decidieron traducirlo para después incorporarlo a un volumen misceláneo destinado a la educación y devoción de los gobernantes indígenas. La idea del árbol, primero como figura de Cristo en la cruz y después como paradigma del buen gobernante cristiano, que se muestra en el texto náhuatl, da pie a los lectores indígenas, a quienes estaba destinada esta obra, a concebir un nuevo tipo de cristianismo, donde ciertos elementos podían ser leídos e interpretados desde la óptica indígena, pues en el pensamiento mesoamericano el árbol también solía asociarse a la figura del tlahtoani o gobernante.
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
Authors: Dicks Amanda R , Maksaev Grigory I , Harissa Zainab , Savadipour Alireza , Tang Ruhang , Steward Nancy , Liedtke Wolfgang , Nichols Colin G , Wu Chia-Lung , Guilak Farshid
Published: February 2023

Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease severity remain unknown. Here, we use CRISPR-Cas9-edited human-induced pluripotent stem cells (hiPSCs) harboring either the mild V620I or lethal T89I mutations to elucidate the differential effects on channel function and chondrogenic differentiation. We found that hiPSC-derived chondrocytes with the V620I mutation exhibited increased basal currents through TRPV4. However, both mutations showed more rapid calcium signaling with a reduced overall magnitude in response to TRPV4 agonist GSK1016790A compared to wildtype (WT). There were no differences in overall cartilaginous matrix production, but the V620I mutation resulted in reduced mechanical properties of cartilage matrix later in chondrogenesis. mRNA sequencing revealed that both mutations up-regulated several anterior HOX genes and down-regulated antioxidant genes CAT and GSTA1 throughout chondrogenesis. BMP4 treatment up-regulated several essential hypertrophic genes in WT chondrocytes; however, this hypertrophic maturation response was inhibited in mutant chondrocytes. These results indicate that the TRPV4 mutations alter BMP signaling in chondrocytes and prevent proper chondrocyte hypertrophy, as a potential mechanism for dysfunctional skeletal development. Our findings provide potential therapeutic targets for developing treatments for TRPV4-mediated skeletal dysplasias.
The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism
Authors: Wiest Christoph , Torrecillos Flavie , Pogosyan Alek , Bange Manuel , Muthuraman Muthuraman , Groppa Sergiu , Hulse Natasha , Hasegawa Harutomo , Ashkan Keyoumars , Baig Fahd , Morgante Francesca , Pereira Erlick A , Mallet Nicolas , Magill Peter J , Brown Peter , Sharott Andrew , Tan Huiling
Published: February 2023

Periodic features of neural time-series data, such as local field potentials (LFPs), are often quantified using power spectra. While the aperiodic exponent of spectra is typically disregarded, it is nevertheless modulated in a physiologically relevant manner and was recently hypothesised to reflect excitation/inhibition (E/I) balance in neuronal populations. Here, we used a cross-species in vivo electrophysiological approach to test the E/I hypothesis in the context of experimental and idiopathic Parkinsonism. We demonstrate in dopamine-depleted rats that aperiodic exponents and power at 30–100 Hz in subthalamic nucleus (STN) LFPs reflect defined changes in basal ganglia network activity; higher aperiodic exponents tally with lower levels of STN neuron firing and a balance tipped towards inhibition. Using STN-LFPs recorded from awake Parkinson’s patients, we show that higher exponents accompany dopaminergic medication and deep brain stimulation (DBS) of STN, consistent with untreated Parkinson’s manifesting as reduced inhibition and hyperactivity of STN. These results suggest that the aperiodic exponent of STN-LFPs in Parkinsonism reflects E/I balance and might be a candidate biomarker for adaptive DBS.
Protein S Deficiency with Favourable Foetomaternal Outcome: A Case Report
Authors: Sugandha Swati , Sharma Shivanshi , Jindal Monika , Minhas Santosh
Published: February 2023

Protein S is a multifunctional plasma protein, whose deficiency,results in a rare congenital thrombophilia, inherited in an autosomal dominant pattern. It can aggravate the hypercoagulable state of pregnancy, when it presents in parallel with the condition, leading to adverse maternal outcomes and foetal loss. A 35-year-old female third gravida having previous 2 deliveries by Lower Segment Caesarean Section (LSCS) presented to emergency at 10 weeks pregnancy with chief complaints of pain and swelling in left thigh since 4-5 days. After thorough investigations and work-up, the patient was diagnosed with Protein S deficiency. She was managed conservatively and was delivered by elective LSCS with bilateral tubal ligation at 38 weeks of gestation with good foetal and maternal outcomes.The rarity of Protein S deficiency along with the successful outcome of the pregnancy makes this a unique case.
Role of Two Antibodies Panel High Molecular Weight Cytokeratin and Alpha-MethylacylCoA Racemase in Diagnosing Prostatic Lesions: A Cross-sectional Study
Authors: Azad Sheenam , Bahal Neelima , Rawat Kavita , Acharya Seema , Vijjan Vivek
Published: February 2023

Introduction: Prostatic diseases cause significant morbidity and mortality. Although histopathological examination is the gold standard for diagnosing prostatic lesions but diagnosis may be challenging in the presence of benign mimickers or a very small focus of malignancy. Immunohistochemical aid to morphology helps in making a timely and accurate diagnosis. Aim: This study was done to evaluate the role of two antibodies panel High Molecular Weight Cytokeratin (HMWCK) and AlphaMethylacyl-CoA Racemase (AMACR) in improving the diagnostic accuracy of prostatic lesions. Materials and Methods: This was an observational cross-sectional study conducted in the Department of Pathology, Shri Guru Ram Rai Institute of Medical and Health Sciences (SGRRIM and HS), Dehradun, Uttarakhand, India, from May 2019 to October 2020. Haemotoxylin and Eosin (H&E) stained sections of prostatic biopsies were classified into benign and malignant. Amongst malignant lesions, prostatic adenocarcinomas were graded according to Gleason’s grading system and Gleason’s scores were noted. One section from each was subjected to AMACR and HMWCK antibody tests. HMWCK was interpreted as negative/positive and continuous/ discontinuous. For AMACR, both location and intensity of stain was observed. The parameters studied were Gleason’s score, group grade, expression of HMWCK and AMACR. Categorical data was presented in form of frequency and percentage. Independent t-test, Yates Chi-square test were used. Data was entered in Microsoft (MS) Excel sheet and analysis was done using CRAN R 2.1. Results: Total of 80 prostatic biopsies were taken, 24 were malignant and 55 were benign and one was Benign Prostatic Hyperplasia (BPH) with a focus suspicious for malignancy showing atypical small acinar proliferation on histopathological examination. The mean age of non neoplastic cases was 67.68±8.56 years, while that of neoplastic lesions was 75.41±9.34 years. Amongst benign, 56.3% (31/55) cases were BPH, 43.6% (24/55) cases were BPH with associated lesions which included 62.5% (15/24) cases of BPH with non specific prostatitis; 29.2% (7/24) cases of BPH with adenosis and 8.3% (02/24) cases of BPH with basal cell hyperplasia. Of malignant cases, 24 cases were of adenocarcinoma with maximum cases having Gleason’s score 9 (11/24;45.8%) and Group grade V (18/24;75%). The sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of HMWCK and AMACR were calculated using histopathology as the gold standard. Conclusion: Although histopathology is the gold standard in prostatic biopsies but immunohistochemistry is additional diagnostic aid in confirmation of diagnosis. Immunohistochemistry not only confirms the histological diagnosis but is of great help in challenging cases. It has markedly increased the diagnostic accuracy
A Combined Case of Neonatal Teeth, Bohn’s Nodules and Eruption Haematoma in an Infant Presenting as a Diagnostic Dilemma
Authors: Vaid Parika , Chouhan Harmesh Lal , Yadav Nitish , Dogra Shikha
Published: February 2023

Abnormalities in the oral cavity of infants are not uncommon, but most are innocuous and resolve with age in the absence of treatment. Some of the most prevalent oral findings are oral inclusion cysts, vascular lesions, natal and neonatal teeth. The American Academy of Paediatric Dentistry (AAPD) recognises that perinatal and infant oral health are the basics upon which preventive education and dental care must be built to enhance the opportunity for a child to have a lifetime free from preventable oral disease This report describes the clinical presentation, diagnosis and suggestive management for a 32-day-old male child patient reported with neonatal teeth, Bohn’s nodules and further at the age of 18 months, with eruption haematoma in the maxillary alveolar region. “Bohn’s nodules” are keratin-filled cysts with prevalence of 47.4% with no gender predilection. Natal and neonatal teeth considered as critically important conditions as their presence can lead to numerous complications such as ulceration on the ventral surface of the tongue caused by the sharp incisal edge of the tooth and condition known as Riga-Fede disease or syndrome. “Eruption haematoma” is circumcoronal cystic cavity which contains blood usually associated with an erupting primary or permanent tooth which is in its soft tissue eruption phase. Therefore, a thorough clinical examination and knowledge of the various lesions is essential for precise diagnosis, management, as well as parental counselling.
Disease Spectrum and Triage Assessment among Children Presenting to the Paediatric Emergency Department at a Tertiary Care Centre in Telangana, India
Authors: Cherukuri Nirmala , Madakkagari Harika , Malyala Sindhu , Tirumani Hima Bindu , Cherukuri Harshita
Published: February 2023

Introduction: Triage is a sorting process to quickly assess patients upon their arrival in the emergency department which helps to stream them to an appropriate location and adequate treatment. Triage assessment helps in recognising the commonly presenting childhood emergencies to optimise quality of care delivered in the Paediatric Emergency Department. Priority attention can be given to the critically ill or injured patients as how long the patient can safely wait, is predicted by triage. Aim: To provide data on disease spectrum and triage assessment of children presenting to an exclusive Paediatric Emergency Department. Materials and Methods: This was a cross-sectional study which was conducted from October 2020 to September 2021 over a period of one year in the Paediatric Emergency Department at Niloufer Hospital, a tertiary care children hospital in Hyderabad, Telangana, India. All children in the age group of one month to twelve years triaged by fivelevel Canadian triage and acute scale were included in the study. Data was collected from the register maintained at the Emergency Department. Descriptive statistics was used to analyse the data. Micosoft excel sheets were used for recording data. Results: During the study period, 7986 children were admitted with 5718 (71.6%) males and 2268 (28.4%) females. A total of 4352 (54.5%) patients were less than one year age. Neurological emergencies, acute febrile illnesses, respiratory illnesses were most common reasons for emergency visits. The number of chidren presenting with triage level 1,2,3 were n=4369 (54.71%). Conclusion: Majority of the patients attending the Emergency Department were less than one year old and acute febrile illnesses and seizures were the most common causes for admissions. Triaging and priorisation of pediatric emergencies is strogly recommended for early recognition of life threatening illnesses and to improve outcomes. Specially trained nurses, healthcare professionals trained in Basic Life Support (BLS) and Paediatric Advanced Life Support (PALS) will go a long way in reducing morbidity and mortality.
Sitting against Lateral Position for Spinal Anaesthesia in Elderly Patients Undergoing Lower Limb Surgeries: An Observational Study
Authors: Bansal Shilpa , Rao Minnu Mridul Pandit , Rao Mridul M Pandit
Published: February 2023

Introduction: Age-related degenerative anatomical changes may make the spinal anaesthesia difficult. Sitting position is preferable due to easy identification of landmarks whereas lateral position is easy to maintain in case of elderly premedicated patients. Aim: To compare the effects of spinal anaesthesia position (sitting versus lateral) in the elderly patients on block characteristics (sensory and motor), haemodynamic parameters, patient’s comfort and satisfaction. Materials and Methods: The present prospective observational study was conducted in the Department of Anaesthesiology and Intensive care, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India, from November 2021 to May 2022. A total of 116 American Society of Anaesthesiologists (ASA) grade I-II patients of both sexes, age more than 70 years undergoing lower limb surgeries under spinal anaesthesia either sitting or lateral position were included in the study. These patients were divided in to two groups (sitting position-Group SP, lateral position-Group LP). Hyperbaric bupivacaine (0.5%) was injected into the subarachnoid space. After the spinal injection, assessments were made for block characteristics (sensory and motor), haemodynamic parameters and patient’s comfort and satisfaction. The discrete and categorical variables were analysed using Chi-square test. Results: The mean age of participants in Group SP and Group LP was 77.31±4.015 years and 76.69±4.901 years, respectively. Onset of sensory block after was significantly slower in Group SP (75.31±10.384 seconds) as compared to Group LP (64.23±7.758 seconds). Time required to achieve maximum level of sensory block was significantly higher in Group SP (8.11±1.416 minutes) than Group LP (6.67±1.324 minutes). There was no significant difference in Heart Rate (HR) in both groups, but there was significantly lower Systolic Blood Pressure (SBP) in Group SP than Group LP up to 12 minutes after spinal injection. However, the lateral position appears to be more comfortable for elderly patients as per the comfort score. Conclusion: Position for spinal anaesthesia, either sitting or lateral, has insignificant effects on block characteristics or on haemodynamic parameters except there was faster onset of sensory and motor block and more comfort in lateral position.
Valuation of Compensation for Land Use Restriction
Authors: Shieh Jeng-Ying , Su Yu-Te
Published: February 2023

The Spatial Planning Act of Taiwan was implemented on May 1, 2016. To protect the legal rights of landholders, the Ministry of the Interior stipulated Measures for Compensating Loss Incurred during The Implementation of Spatial Planning in accordance with Article 32, Paragraph 3 of the Spatial Planning Act. Compensation is available for relocation or for alteration, where alteration refers to compensation for losses incurred when constructible land is made non-constructible by a special municipality or county (city) and the land cannot be built on. It therefore includes compensation for the value of the right to develop the land.

Real estate is immobile and inflexible, which reduces uncertainty in its use. Studies have generally used net present value to analyze investment in and development of land. The conventional passive net present value method is employed to appraise land value, usually assuming that the investment plan must be developed immediately and is reversible. This is contrary to the characteristics of real estate investment and development, where ignoring the opportunities and flexibility generated by asset value uncertainty can readily lead to misappraisal of the value of an investment plan. The inclusion of future uncertainty in the valuation is the main difference between the option valuation model and the conventional valuation model.

Because correctly calculating the compensation for alteration is crucial to whether landowners successfully obtain appropriate compensation when applying for compensation, this study proposed a real option valuation model to appraise compensation for the alteration of privately-owned constructible land. In the model, landowners possessed complete ownership of and decision-making power regarding the land before compensation. Subsequently, the study adopted real options theories to assist private landowners in determining real options at the decision-making stage. The study also took the case of constructible land in Taichung City that was made non-constructible in accordance with the spatial planning of Taichung City as an example to apply the model.
Combined Exponential-Type Estimators for Finite Population Mean in Two-Phase Sampling
Authors: Oyeyemi G. M. , Muhammad I. , Kareem A. O.
Published: February 2023

A family of exponential-type estimator for estimating population mean in two-phase sampling when the population proportion of the auxiliary character is available is proposed in this paper. Theoretically, the bias and minimum mean square error (MSE) for the proposed estimator are obtained. The expression for MSE of the proposed exponential-type of estimator is compared with the existing estimators in the literature. The optimum values of the parameters are determined. An empirical study was carried out by comparing the proposed estimators with some of the existing estimators reviewed in the literature based on the criteria of bias, mean square error (MSE) and relative efficiency using life datasets. The result of the comparisons showed that the proposed exponential-type estimators produce a better estimate of finite population mean than the existing estimators in the sense of having higher percentage relative efficiency which implies lesser mean square error and bias. Furthermore, the realistic conditions under which the proposed class of exponential-type estimators is more efficient were also presented. Thus, the proposed estimators can be considered as significant alternatives to estimating population characteristics of real life datasets.
Incorporating Social Determinants of Health Into Medical Decision-making—Implications for Dermatology
Authors: Venkatesh Kaushik P. , Jothishankar Balaji , Nambudiri Vinod E.
Published: February 2023

This Viewpoint discusses incorporating social determinants of health into medical decision-making and its implications for dermatology.
Geographic Variation in Disease Burden and Mismatch in Care of Patients With Rheumatoid Arthritis in the United States
Authors: Dowell Sharon , Yun Huifeng , Curtis Jeffrey R. , Chen Lang , Xie Fenglong , Pedra‐Nobre Manuela , Wollaston Dianne , Najmey Sawsan , Elliott Cynthia Lawrence , Ford Theresa Lawrence , North Heather , Dore Robin , Dolatabadi Soha , Ramanujam Thaila , Kennedy Stacy , Ott Stephanie , Jileaeva Ilona , Richardson Amina , Kaine Jeffrey , Wright Grace , Kerr Gail S.
Published: February 2023

Objective

Our objective was to evaluate the factors associated with regional variation of rheumatoid arthritis (RA) disease burden in the US.

Methods

In a retrospective cohort analysis of Rheumatology Informatics System for Effectiveness (RISE) registry data, seropositivity, RA disease activity (Clinical Disease Activity Index [CDAI], Routine Assessment of Patient Index Data–version 3 [RAPID3]), socioeconomic status (SES), geographic region, health insurance type, and comorbidity burden were recorded. An Area Deprivation Index score of more than 80 defined low SES. Median travel distance to practice sites’ zip codes was calculated. Linear regression was used to analyze associations between RA disease activity and comorbidity adjusting for age, sex, geographic region, race, and insurance type.

Results

Enrollment data for 184,722 patients with RA from 182 RISE sites were analyzed. Disease activity was higher in African American patients, in those from Southern regions, and in those with Medicaid or Medicare coverage. Greater comorbidity was prevalent in patients in the South and those with Medicare or Medicaid coverage. There was moderate correlation between comorbidity and disease activity (Pearson coefficient: RAPID3 0.28, CDAI 0.15). High‐deprivation areas were mainly in the South. Less than 10% of all participating practices cared for more than 50% of all Medicaid recipients. Patients living more than 200 miles away from specialist care were located mainly in Southern and Western regions.

Conclusion

A disproportionately large portion of socially deprived, high comorbidity, and Medicaid‐covered patients with RA were cared for by a minority of rheumatology practices. Studies are needed in high‐deprivation areas to establish more equitable distribution of specialty care for patients with RA.
Mesenchymal Stem Cell‐Laden Composite β Cell Porous Microgel for Diabetes Treatment
Authors: Sun Ji , Li Jingbo , Huan Zhikun , Pandol Stephen J. , Liu Dechen , Shang Luoran , Li Ling
Published: February 2023

Type 1 diabetes mellitus is a chronic metabolic condition characterized by the autoimmune damage of pancreatic β cells. As an alternative to continuous exogenous insulin administration of insulin, β cell transplantation is shown to provide an alternative approach for controlling hyperglycemia in diabetes. However, β cell transplantation faces significant challenges of low β cell proliferation and immunologic insults. Thus, novel approaches capable of promoting the islet microenvironment for sustainability is highly desired. This study develops mesenchymal stem cell (MSC)‐laden composite β cell porous microgels (MGs) to address sustainability for the treatment of diabetes. The MGs are prepared via microfluidic droplet templates encapsulating both MSCs and β cells with porogen for creating a porous structure. In addition to offering a suitable microenvironment for nutrient delivery, the porous structure promoted β cell growth and insulin secretion. The outstanding anti‐apoptotic and immunomodulatory roles of MSCs further provide a favorable environment for β cell survival and function. On this basis, the therapeutic performance of the MGs in reducing hyperglycemia and achieving sustained glycemic control in diabetic mice is demonstrated. Collectively, these results show that the novel MGs have great potential for the treatment of diabetes providing a promising platform for clinical β cell transplantation.
Decoding Li+/Na+ Exchange Route Toward High‐Performance Mn‐Based Layered Cathodes for Li‐Ion Batteries
Authors: Cao Bo , Chen Zhefeng , Cao Hongbin , Zhu Chen , Yang Hongkai , Li Tianyi , Xu Wenqian , Pan Feng , Zhang Mingjian
Published: February 2023

Li+/Na+ exchange has been extensively explored as an effective method to prepare high‐performance Mn‐based layered cathodes for Li‐ion batteries, since the first report in 1996 by P. G. Bruce (Nature, 1996. 381, 499–500). Understanding the detailed structural changes during the ion‐exchange process is crucial to implement the synthetic control of high‐performance layered Mn‐based cathodes, but less studied. Herein, in situ synchrotron X‐ray diffraction, density functional theory calculations, and electrochemical tests are combined to conduct the systemic studies into the structural changes during the ion‐exchange process of an Mn‐only layered cathode O3‐type Li0.67[Li0.22Mn0.78]O2 (LLMO) from the corresponding counterpart P3‐type Na0.67[Li0.22Mn0.78]O2 (NLMO). The temperature‐resolved observations combined with theoretical calculations reveal that the Li+/Na+ exchange is favorable thermodynamically and composited with two tandem topotactic phase transitions: 1) from NLMO to a layered intermediate through ≈60% of Li+/Na+ exchange. 2) then to the final layered product LLMO through further Li insertion. Moreover, the intermediate‐dominate composite is obtained by slowing down the exchange kinetics below room temperature, showing better electrochemical performance than LLMO obtained by the traditional molten‐salt method. The findings provide guides for the synthetic control of high‐performance Mn‐based cathodes under mild conditions.
Configurationally Confined Multilevel Supramolecular Assemblies for Modulating Multicolor Luminescence
Authors: Tian Mengdi , Wang Ze , Yuan Xing , Zhang Heng , Liu Zhixue , Liu Yu
Published: February 2023

Herein, multilevel supramolecular assemblies are reported based on sulfobutylether‐β‐cyclodextrin (SBE‐βCD) and cucurbit[8]uril (CB[8]), which can control the topological morphology from nanoparticles to nanosheets and modulate the multicolor luminescence. Benefiting from the large cavity of CB[8] and its strong binding affinity with positively charged tetraphenylethylene pyridinium (TPE‐Py), a 1:2 stoichiometric supramolecular assembly is formed through host–guest interactions with binding constants of 2.95 × 1011 M−2 and fluorescence bathochromic shift about 35 nm due to the macrocyclic confinement effect, thereby endowing the fluorescence enhancement about 20 times when further assembled with negatively charged SBE‐βCD to form nanosheets through electrostatic interactions. In contrast, the direct assembly of TPE‐Py and SBE‐βCD can form nanoparticles through electrostatic interactions, showing only tenfold enhancement and no bathochromic shift due to the lack of macrocyclic confinement effect. After doping the near‐infrared dye acceptor sulfonated aluminum phthalocyanine (AlPcS4), the nanosheets structure exhibits a higher energy transfer efficiency of about 75% and a larger antenna effect of 29.3 than that of nanoparticles. The multilevel supramolecular assemblies can be used in multicolor luminescence information storage and multiple logical gate systems, providing an efficient approach for configurationally confined topological morphology regulation and luminescent materials.
Bioinspired Liquid Crystalline Spinning Enables Scalable Fabrication of High‐Performing Fibrous Artificial Muscles
Authors: Hou Wenhao , Wang Jiao , Lv Jiu‐an
Published: February 2023

Leveraging liquid crystal elastomers (LCEs) to realize scalable fabrication of high‐performing fibrous artificial muscles is of particular interest because these active soft materials can provide large, reversible, programmable deformations upon environmental stimuli. High‐performing fibrous LCEs require the used processing technology to enable shaping LCEs into micro‐scale fine fibers as thin as possible while achieving macroscopic LC orientation, which however remains a daunting challenge. Here, a bioinspired spinning technology is reported that allows for continuous, high‐speed production (fabrication speed up to 8400 m h−1) of thin and aligned LCE microfibers combined with rapid deformation (actuation strain rate up to 810% s−1), powerful actuation (actuation stress up to 5.3 MPa), high response frequency (50 Hz), and long cycle life (250 000 cycles without obvious fatigue). Inspired by liquid crystalline spinning of spiders that takes advantage of multiple drawdowns to thin and align their dragline silks, internal drawdown via tapered‐wall‐induced‐shearing and external drawdown via mechanical stretching are employed to shape LCEs into long, thin, aligned microfibers with the desirable actuation performances, which few processing technologies can achieve. This bioinspired processing technology capable of scalable production of high‐performing fibrous LCEs would benefit the development of smart fabrics, intelligent wearable devices, humanoid robotics, and other areas.