bluuebunny/crossref_metadata_2025 huggingface dataset:
The future of dream science
Authors: Bulkeley Kelly
Published: June 2017

This article describes the future prospects of scientific dream research. Three frontiers of investigation hold special promise: neuroscientific studies of the brain–mind system's activities during sleep (such as during lucid dreaming); systematic analyses of large collections of dream reports from diverse populations of people; and psychotherapeutic explorations of the multiple dimensions of personal and collective meaning woven into the dream experiences of each individual. Several helpful books on the science of sleep and dreaming are mentioned for further study.
Ice‐Breaker vs. Standalone: Comparing Alternative Workflow Modes of Mid‐level Care Providers
Authors: White Denise L. , Torabi Elham , Froehle Craig M.
Published: June 2017

Capitalizing on the operational concept of division‐of‐labor, clinics often reduce physician service time by off‐loading some of his/her clinical activities to lower‐cost personnel. These personnel, such as nurse practitioners and physician assistants, are often collectively referred to as “mid‐level providers” (MLPs) and can perform many patient‐consultation tasks. The common rationale is that using an MLP allows the physician to serve more patients, increase patients’ access to care, and, due to MLPs’ lower salaries, improve the clinic's financial performance. An MLP is typically integrated into the outpatient clinic process in one of two modes: as an “ice‐breaker,” seeing each patient before the physician, or as a “standalone” provider, a substitute for the physician for the entirety of some patients’ visits. Despite both of these modes being widely used in practice, we find no research that identifies the circumstances under which either one is preferable. This study examines these two modes’ effects on operational performance, such as patient flow and throughput, as well as on financial measures. Using queueing and bottleneck analysis, discrete‐event simulation, and profit modeling, we compare these two deployment modes and identify the optimal policies for deploying MLPs as either ice‐breakers or as standalone providers. Interestingly, we also find there exists a range of scenarios where not hiring an MLP at all (i.e., the physician works alone) is likely to be most profitable for the clinic. Implications for practice are discussed.
Blastomyces dermatitidis peritonitis complicating peritoneal dialysis
Authors: Sanghvi Yogesh , Somers Douglas
Published: June 2017

Fungal peritonitis is an uncommon complication in peritoneal dialysis patients. We report a case of blastomyces dermatitis peritonitis in a nonimmunocompromised peritoneal dialysis patient, who initially presented with symptoms of lower extremity weakness and altered mental status. Peritoneal blastomycosis is rare condition and not previously reported in end stage renal disease patients on peritoneal dialysis. Fungal peritonitis can present with subtle clinical findings so a high index of suspicion is needed as early detection and treatment may decrease mortality and morbidity.
Environmental Constitutionalism in the United States and Nigeria: Recognizing Environmental Rights
Authors: Okonkwo Theodore
Published: June 2017

Environmental constitutionalism is a scheme that protects the national and international environment by applying national and global constitutional law. By this, constitution-makers agree to include in their constitutions provisions aimed at environmental protection and sustainability, whereby procedural and substantive rights are written in the constitutions. The courts are in such jurisdictions called upon to enforce and protect such rights. This article addresses constitutionally embedded rights in the national constitutions of the United States of America and Nigeria. It analyzes constitutional environmental provisions in both how their judiciaries respond to such issues. This article looked at the problems associated with environmental constitutionalism in the United States and Nigeria and their connection with environmental rights. The aim is to take a holistic examination of the topic. The methodology adopted for the research is empirical. The primary and secondary sources of material selection were adopted through the use of the law libraries and the internet, books, journals and periodicals to gather information for this article. In conclusion, it was observed and recommended that no matter the similarities shared by the Untied States and Nigeria, the former has a more developed environmental jurisprudence on environmental protection by the courts. This is a truism, notwithstanding the fact that Nigeria’s constitution contains “state environmental duties”. The value of the research is that Nigeria should identify areas to be improved upon in its law and practice of environmental constitutionalism.
Proportion of effects by head-related transfer function and receiver position variation to interaural cross-correlation values
Authors: Pätynen Jukka
Published: June 2017

Interaural cross-correlation coefficient (IACC) is an objective room-acoustic parameter associated with the spatial impression and subjective quality of the acoustics. This study investigates the proportion of effects on the IACC variance simultaneously by (1) varied head-related transfer function (HRTF) and (2) locally varied receiver positions. The early IACC80 values are estimated from the binaural room simulations in eight room-acoustic conditions varying in room shape, side wall absorption, and receiver distance. Analysis across the combinations of HRTF and receiver positions indicates that below 2 kHz, around two-thirds of total IACC variance is explained by the receiver displacement, and at higher frequencies the HRTF variations dominate the IACC variance.
An unusual case ofEscherichia coliO157:H7 infection with pseudomembranous colitis-like lesions associated with haemolytic-uraemic syndrome and neurological sequelae
Authors: Kennedy James , Simmonds Lauren , Orme Robert , Doherty Warren
Published: June 2017

A 75-year-old man was admitted with abdominal pain and fresh rectal bleeding. Significantly, he had no risk factors forClostridium difficileinfection. An abdominal CT demonstrated colonic thickening, and flexible sigmoidoscopy identified pseudomembranous colitis-like lesions. After initial treatment asC. difficilecolitis, a stool sample revealedEscherichia coliO157:H7 infection. Antibiotic therapy was stopped due to the risk of lysis-mediated toxin release, but unfortunately, the patient continued to deteriorate. He developed several of the severe sequelae ofE. coliO157:H7 infection, including haemolytic-uraemic syndrome with an acute kidney injury necessitating haemofiltration, plus progressively severe seizures requiring escalating antiepileptic treatment and intubation for airway protection. After a prolonged intensive care admission and subsequent recovery on the ward, our patient was discharged alive.
Lipoma of right pyriform sinus
Authors: Jabbr Muhammad Sami , Hamadi Iyad , Fakoury Mouhannad Mahmoud Abdulber , Youssef Gamal Yousef
Published: June 2017

We present a case of large mass arising from the right pyriform sinus extending inferiorly to the postcricoid area and superiorly to the right aryepiglottic fold causing a foreign body sensation and obstructive symptoms, its histological examination following the endoscopic surgical excision showed a lipoma. We are also describing the endoscopic, radiological and intraoperative findings with a brief literature review.
Internal carotid artery occlusion and stroke as a complication of cisplatin-based chemotherapy for metastatic testicular germ cell tumour
Authors: Cerrud-Rodriguez Roberto Christian , Quinteros Maria Gabriela , Azam Mohammed
Published: June 2017

Testicular tumours are the most common tumours in young men. Germ cell tumours (GCTs) account for 95% of all testicular cancers, and the non-seminomatous type (NSGCT) accounts for 50% of all GCTs. Cisplatin-based chemotherapy is curative in up to 90% of patients, but it is not without its inherent risks. Ischaemic stroke is a very uncommon, but severe complication of cisplatin-based chemotherapy. Strokes in young patients cause a disproportionately large economic impact by leaving victims disabled during their most productive years and strains the healthcare system with expensive hospital stays. We present a case of a young male patient with past medical history of metastatic NSGCT with the sudden onset of dysarthria, left hemiplegia and ipsilateral hemisensory loss 3 days after receiving cisplatin-based chemotherapy. Subsequent studies revealed a stroke involving the right middle cerebral artery territory secondary to an acute right internal carotid occlusion.
Chest X-ray of a patient with history of pleural effusion
Authors: Konik Ewa , Schirger John
Published: June 2017

The presented chest X-ray depicts the thoracic duct anatomy of a 50-year-old man who underwent heart transplantation. His postoperative course was complicated by Candida mediastinitis, treated with débridements and closure of the anterior chest wound with myocutaneous flaps. Postoperatively, he had persistent output from a right-sided chest tube. The fluid appeared milky and its triglycerides level was elevated at 254 mg/dL. The drainage persisted despite a low fat diet. The interventional radiologist identified a leak in the upper thoracic duct. It was embolised with coil and onyx. After the procedure, the chylous pleural effusions resolved. The thoracic duct has been visualised on subsequent chest X-rays (figures 1 and 2).
Effects of Cobalt Chloride, a Hypoxia-Mimetic Agent, on Autophagy and Atrophy in Skeletal C2C12 Myotubes
Authors: Chen Rui , Jiang Ting , She Yanling , Xu Jiehua , Li Cheng , Zhou Shanyao , Shen Huijuan , Shi Huacai , Liu Shuang
Published: June 2017

Background. Hypoxia-induced autophagy and muscle wasting occur in several environmental and pathological conditions. However, the molecular mechanisms underlying the effects of the hypoxia-mimetic agent CoCl2 on autophagy and muscle atrophy are still unclear. Methods. C2C12 myotubes were exposed to increasing concentrations of CoCl2 for 24 hours. Quantitative RT-PCR, Western blotting, and transmission electron microscopy were performed to confirm autophagy occurs. Autophagy proteins were measured to understand the molecule mechanisms. We also inhibited hypoxic autophagy and examined the changes in myogenin expression, myotubes formation, and apoptosis. Results. Our results showed that CoCl2-mimicked hypoxia upregulated the expression of the autophagy-related proteins LC3, HIF-1α, BNIP3, p-AMPKα, and beclin-1, whereas p62 and p-mTOR were downregulated. In addition, the autophagosome could be observed after CoCl2 induction. The expression of the autophagy-related E3 ligase parkin and the muscle-specific ubiquitin ligase atrogin-1 was increased by CoCl2. Inhibition of autophagy by 3MA increased myogenin expression and promoted myotubes formation and the percentage of cell death was decreased. Conclusions. Our results confirmed that CoCl2-mimicked hypoxia induced autophagy via the HIF-1α/BNIP3/beclin-1 and AMPK/mTOR pathways. Our results also revealed an important link between autophagy and muscle atrophy under hypoxia, which may help to develop new therapeutic strategies for muscle diseases.
The Efficacy of Trimodal Chemoradiotherapy with Cisplatin as a Bladder-Preserving Strategy for the Treatment of Muscle-Invasive Bladder Cancer
Authors: Nagao Kazuhiro , Hara Takahiko , Nishijima Jun , Shimizu Kosuke , Fujii Nakanori , Kobayashi Keita , Kawai Yoshihisa , Inoue Ryo , Yamamoto Yoshiaki , Matsumoto Hiroaki , Matsuyama Hideyasu
Published: June 2017

Introduction: Open radical cystectomy (ORC) is currently the standard treatment for muscle-invasive bladder cancer (MIBC) without metastasis, while many patients with MIBC are not always appropriate candidates due to multiple comorbidities. To evaluate the bladder-preservation strategy, we compared the results with those obtained by ORC. Patients and Methods: We retrospectively analyzed the data of 50 patients with MIBC treated by trimodal chemoradiotherapy with cisplatin (CDDP-radiation [CDDP-R]). Transurethral resection of the bladder tumor (TURBT) was performed before treatment to confirm pathological stage ≥T2. Extensive TURBT was performed after chemoradiotherapy to evaluate the pathological response to treatment. We compared the survival outcomes of our CDDP-R with those of ORC (retrospective cohort, n = 205) by propensity score matching analysis. Results: The 2- and 5-year progression-free survival, bladder-intact survival, cancer-specific survival, and overall survival (OS) rates after treatment were 70.8 and 63.9%, 64.0 and 49.8%, 86.7 and 71.8%, and 84.3 and 64.8%, respectively. The 2- and 5-year OS rates after CDDP-R were 90.5 and 74.3%, respectively, and those after ORC were 71.8 and 59.9%, respectively, indicating a significant survival advantage conferred by CDDP-R over ORC (p < 0.05, HR 0.45, 95% CI 0.21-0.94). Conclusions: In selected patients, CDDP-R for MIBC may provide comparative oncological outcomes as ORC.
Activation of COX-2/mPGES-1/PGE2 Cascade via NLRP3 Inflammasome Contributes to Albumin-Induced Proximal Tubule Cell Injury
Authors: Zhuang Yibo , Zhao Fei , Liang Jing , Deng Xu , Zhang Yue , Ding Guixia , Zhang Aihua , Jia Zhanjun , Huang Songming
Published: June 2017

Background/Aims: The activation of NOD-like receptor family, pyrin domain containing3 (NLRP3) inflammasome has been shown to be positively correlated with the severity of proteinuria in chronic kidney disease (CKD) patients. Prostaglandin E2 (PGE2), an important inflammatory mediator, is also involved in various kidney injuries. The aim of the present study was to investigate the involvement of NLRP3 inflammasome and PGE2 synthetic pathway in albumin-induced renal tubular injury. Methods: Murine proximal tubular cells (mPTCs) were treated with albumin to induce cell injury. NLRP3 siRNA and specific COX-2 inhibitor NS398 were used to define their roles in mediating albumin-induced mPTC injury or the activation of COX-2/mPGES-1/PGE2 cascade. Results: In mPCTs, inhibition of NLRP3 by a small interfering RNA (siRNA) blocked albumin-induced kidney injury molecule 1 (KIM-1) upregulation, inflammatory response, and cell apoptosis. Albumin markedly activated cyclooxygenase-2 (COX-2)/ microsomal prostaglandin E synthase-1 (mPGES-1)/PGE2 pathway in this cell line, an effect largely abolished by NLRP3 silencing at both mRNA and protein levels. More interestingly, blockade of COX-2 using a specific COX-2 inhibitor NS398 markedly inhibited the upregulation of KIM-1 and inflammatory cytokines, and attenuated cell apoptosis in line with blunted PGE2 release following albumin treatment. Conclusions: The findings suggest that COX-2/mPGES-1/PGE2 axis could be activated by albumin in the proximal tubular cells via a NLRP3 inflammasome-mediated mechanism and could thus contribute to proteinuria-related renal tubular cell injury.
КЛІНІЧНИЙ ВИПАДОК ЗАВІЗНОЇ ТРОПІЧНОЇ МАЛЯРІЇ НА БУКОВИНІ
Authors: Boyko Yu. I. , Moskaliuk V. D. , Andrushchak M. O. , Sokolenko M. O. , Holiar O. I.
Published: June 2017

Малярія – трансмісивна інфекційна хвороба, якій властиві періодичні напади гарячки, збільшення печінки та селезінки, анемія. Її спричиняють п’ять видів плазмодіїв: триденну малярію - P. vivax, чотириденну - P. malariae, особливий вид триденної - P.ovale, тропічну - P. falciparum та раніше невідому knowlesi-малярію - P. knowlesi.Малярія продовжує залишатись великою проблемою сучасної медицини. Загальна частка захворюваності на малярію становить 2,6 % від усіх захворювань у світі. Поширеність малярії залежить від соціальних, природних та біологічних факторів. Завезені випадки малярії з тропіків можуть з’явитися у помірному кліматі в будь-який час. Значну проблему становить лікування цієї недуги у зв’язку із відсутністю протималярійних препаратів в Україні.
СЛАВНИЙ ЮВІЛЕЙ ДІЙСНОГО ЧЛЕНА НАМН УКРАЇНИ, ПРОФЕСОРА ЖАННИ ІВАНІВНИ ВОЗІАНОВОЇ
Authors: Avtoriv Kolektyv
Published: June 2017

Наведена коротка інформація про хід науково-практичної конференції з міжнародною участю «Актуальні інфекційні захворювання. Особливості клініки, діагностики, лікування та профілактики в сучасних умовах», яка відбулася 24–25 листопада 2016 р. у Києві.
Вплив лікувально-профілактичних заходів на показники ротової рідини та клінічний стан тканин пародонта у дітей 6–7 років, хворих на гінгівіт
Authors: Avdeev O. V. , Zmarko Y. K. , Boykiv A. B. , Drevnitska R. O.
Published: June 2017

The high prevalence of inflammatory processes in the periodontitis of children, the ineffective effectiveness of preventive and curative measures can contribute to the development of generalized periodontitis, therefore it remains urgent to develop pathogenetic effects in the treatment of chronic catarrhal gingivitis.The aim of the study – a comparative assessment of the traditional treatment of chronic catarrhal gingivitis in children aged 6–7 years with therapy using an anti-inflammatory gel with neovitin.Materials and Methods. 61 children aged 6–7 years, suffering from chronic catarrhal gingivitis, were taken under clinical supervision and divided into groups: the main (30 children) and the comparative (31 children). All children underwent conventional therapy in accordance with the protocols for the provision of medical care – basic therapy. In the main group, for a month, pathogenetic agents were used: an anti-inflammatory gel with neovitin, hygiene products were recommended. In the comparative group, 3 % hydrogen peroxide solution was used for local therapy, for rinsing of the mouth (during the first week of treatment) – Rotokan, a therapeutic and prophylactic toothpaste.Examination and control examinations were carried out with the hygienic state of the mouth determined by the hygienic index of Yu. A. Fedorov and V. V. Volodkina, prevalence and intensity of the inflammatory process in the gums with the help of the Schiller-Pisarev test and the PMA index, oral fluid index (lysozyme content, formation of oxydradicals, urease activity, degree of dysbiosis, pH and viscosity).Results and Discussion. After the treatment, elimination of gum inflammation in patients of the main group was accompanied by a decrease in the PMA index by 3.8 times; formation of oxyradicals decreased in children of the main group by 6.35 %; in the comparative group – by 6.15 %. Urease activity decreased in children of the main group by 16.37 % (p<0.05), the viscosity of the oral fluid of children decreased in 2.65 times in the main group and in 2.13 times in the comparative group (p<0.05). The lysozyme content increased in children of the main group by 15.61 % (p<0.05) in the comparison group – by 9.63% (p<0.05). The treatment after 0.5 years caused an increase in the lysozyme content in the oral fluid of the children of the main group to the level of the control group. The degree of dysbiosis decreased in the main group, in the comparison group tended to increase.Conclusions. The use of the proposed therapy with gel with neovitin contributed to the best results of treatment: reducing the degree of inflammation of the gums, the number of visits to the doctor, improving the indices of nonspecific protection in the oral fluid of 6-7 years-old children and, to a greater extent, six months after the treatment.
Мікробіологічна характеристика та динаміка змін біоценозу тканин ясен у хворих на генералізований катаральний гінгівіт із хронічним та загостреним перебігом під впливом проведеної комплексної терапії
Authors: Kuzniak N. B. , Shostenko A. A.
Published: June 2017

Generalized catarrhal gingivitis occupies one of the first places among diseases of periodontal tissues in young people, which is confirmed by numerous studies of both foreign and domestic scientists.The aim of the study – to examine the condition of microbiocenosis of gingival tissues in patients with generalized catarrhal gingivitis with various clinical course, assessment of the effect of the proposed step-wise complex therapy on the clinical and laboratory indices of the disease.Materials and Methods. The article presents the data of a comparative analysis of gingival tissue microbiocoenos is peculiarities and the results of correction of the indices changes in 82 patients with generalized catarrhal gingivitis with variable clinical course.  The objective state of the oral cavity and gums was established on the basis of the dynamics of the following tests: a simplified hygiene index (OHI-S), Müllmann, Cowel, and papillary-marginal-alveolar index (PMA).Results and Discussion. To determine the biocenosis of gingival tissues, a classical bacterial culture method was used to determine the quantitative and specific composition of the microflora. Opportunistic streptococcal microflora of the oral cavity was found to occupy a leading role in the development of chronic catarrhal gingivitis, while staphylococci and the fungi of Candida genus are the main agents provoking exacerbations. A comprehensive treatment was elaborated and introduced into practice supposing the use of professional hygienic measures, anti-inflammatory, antibacterial, immunomodulating drugs and probiotics at different stages of treatment. Conclusions. The use of traditional antibiotic therapy in patients with chronic generalized catarrhal gingivitis with additional inclusion of bifidobacterin and cycloferon optimized the effectiveness of treatment: recovery of gum tissue was achieved in 93.5 % of patients and was accompanied by complete elimination of possible pathogens in the gingival tissues.
Клінічний випадок лікування інфікованої рани стегна з ураженням синтетичного судинного протеза
Authors: Vykhtyuk T. I. , Orel Yu. H. , Gavryliv B. M. , Terletsky I. R. , Verhola M. B. , Khorkavyi Yu. Z.
Published: June 2017

Мета роботи: було дослідження клінічного випадку ускладненої інфікованої післяопераційної рани стегна у хворого після реконструкції дистального анастомозу біфуркаційного алопротеза та аналіз результатів її лікування із застосуванням ВАК-терапії.У статті представлено клінічний випадок інфікованої рани стегна у хворого після реконструкції псевдоаневризми дистального анастомозу через три роки після біфуркаційного аорто-стегнового протезування. Стратегія лікування ускладненої післяопераційної рани полягала у поєднанні системної антибіотикотерапії із локальною вакуум-асистованою терапією рани. На підставі результатів посіву вмісту рани на патогенну мікрофлору із визначенням чутливості до антибіотиків було верифіковано збудники та підібрану цільову антибактеріальну терапію. Локальний клінічний ефект вакуум-асистованої терапії виявлявся в адекватному дренуванні вмісту ускладненої інфікованої рани. Застосування даного лікувального комплексу в описаного пацієнта дозволило досягти позитивної динаміки інфекції ділянки хірургічного втручання із остаточною ліквідацією інфекційного осередку через сім тижнів. Вищезгадане комбіноване лікування є ефективним комплексним способом загоєння післяопераційної рани. Віддалене спостереження пацієнта протягом шести місяців підтвердило відсутність інфекції рани та ознак псевдоаневризми.
Гангрена фурньє, як урогенітальна форма некротизуючого фасціїту – модель критичного стану організму в хірургії
Authors: Priyma O. B. , Fedorovych I. V. , Korin V. V. , Olenych G. Ya.
Published: June 2017

Мета роботи: проаналізувати перебіг і наведені методи лікування хворих на гангрену Фурньє.Матеріали і методи. У роботі узагальнено 25-річний досвід на прикладі лікування 16 хворих на гангрену Фурньє. Наведено біохімічні показники цих хворих. Крім того, показано хірургічні втручання, які були виконані у цих хворих, а також їх інтенсивну інфузійну терапію.Результати досліджень та їх обговорення. Показано, що серед розмірів ураження некротичним процесом переважне значення має площа некрозу. Вираження ендотоксикозу – істотне, бо наявність недостатності трьох і більше систем внутрішніх органів є несприятливою ознакою результату захворювання.
Прогностичні маркери проліферації та апоптозу в пацієнтів на вузлові форми зоба на фоні автоіму-нного тиреоїдиту
Authors: Bedenyuk A. D. , Sheremet M. I. , Sydorchuk L. P. , Shidlovskyi V. O.
Published: June 2017

Мета роботи: вивчити процеси апоптозу та проліферації в пункційному матеріалі щитоподібної залози (ЩЗ) при вузловому зобі на фоні автоімунного тиреоїдиту ВЗАІТ з використанням імуногістохімічного методу дослідження, а також визначити індекс проліферативної активності.Матеріали і методи. На пункційному матеріалі ЩЗ, отриманому від 75 хворих із гістологічно верифікованим діагнозом ВЗАІТ, проведено імуногістохімічне дослідження шляхом використання моноклональних антитіл проти Fas, FasL, Bcl-2, P53 та Ki67 антигенів.Результати досліджень та їх обговорення. Результати показали ступінь проліферативної активності тканини ЩЗ при ВЗАІТ. Виявлено високу проліферативну активність лімфоїдної тканини, помірну проліферативну активність тиреоцитів у ділянці лімфоїдної інфільтрації і низьку – поза нею. Виражена експресія Fas та FasL на тиреоцитах, у ділянках лімфоїдної інфільтрації побічно свідчить про те, що при ВЗАІТ відбуваються імунологічно зумовлені процеси апоптозу тиреоцитів. Збільшення кількості імунореактивних клітин, що експресують Ki67 у ділянці лімфоїдної інфільтрації і деструкції тиреоцитів, свідчить про регенерацію фолікулярного епітелію як компенсаторно-пристосувальну реакцію органа. Виражена експресія bsl-2 у лімфоцитах запобігає вхід клітин в апоптоз і подовжує час виживання клітин. Спостерігалася висока експресія протеїну р53 в ядрах тиреоцитів та фолікулярних просвітах, яку можна пояснити мутаціями гена р53, що дозволяє клітинам знайти толерантність до апоптичної  дії ефекторів імунної системи.
Клінічний випадок “защемлення” колоноскопа в грижовому мішку у хворого з лівобічною пахвинно-калитковою грижею
Authors: Bedeniuk A. D. , Futuyma Yu. M. , Burak A. Ye. , Netsiuk O. H. , Balaban L. V.
Published: June 2017

У статті представлено унікальний клінічний випадок, особливості клініки, діагностики та хірургічного лікування “защемлення” колоноскопа в грижовому мішку у хворого з лівобічною пахвинно-калитковою грижею.
Порівняльна оцінка динаміки холестатичних та цитолітичних показників і темпу декомпресії жовчних проток після одноетапних лапароскопічних та відкритих операційних втручань у хворих на холедохолітіаз, ускладнений обтураційною жовтяницею (повідомлення 2)
Authors: Nychytaylo M. Yu. , Dzubanovskyi O. I.
Published: June 2017

Мета роботи: визначити темп декомпресії жовчних проток та оцінку показників синдромів цитолізу й холестазу після одноетапних лапароскопічних і відкритих операційних втручань у пацієнтів із холедохолітіазом, ускладненим обтураційною жовтяницею.Матеріали і методи. Проведено порівняння динаміки біохімічних показників холестазу й цитолізу та темпу біліарної декомпресії у 81 хворого з холедохолітіазом, ускладненим обтураційною жовтяницею, із різним рівнем білірубіну, на 3-тю, 5-ту та 7-му добу після одноетапних лапароскопічних і відкритих операційних втручань. Темп відповіді жовтяниці на декомпресію визначали за формулою T. Shmizu і K. Yoshida в модифікації Э. И. Гальперина.Результати досліджень та їх обговорення. Встановлено, що лапароскопічна холедохолітотомія у пацієнтів із рівнем гіпербілірубінемії до 100 мкмоль/л і від 100 до 200 мкмоль/л супроводжується затяжним і помірним темпом декомпресії, що є оптимальним у післядекомпресійному періоді. У хворих із рівнем гіпербілірубінемії від 100 до 200 мкмоль/л, яким виконаний холедоходуоденоанастомоз, відмічається швидкий  темп декомпресії в післяопераційному періоді, що потребує профілактичної медикаментної корекції можливого синдрому “швидкої декомпресії”.
ВИКОРИСТАННЯ ПРИНЦИПІВ Е-МЕДИЦИНИ В УМОВАХ ДЕРЖАВНО-ПРИВАТНОГО ПАРТНЕРСТВА В РЕАБІЛІТОЛОГІЇ. ПОСТАНОВКА ЗАВДАННЯ
Authors: Mintser O. P. , Sinyenko N. O. , Haninets P. P. , Sarkanich O. V. , Semivolos A. V. , Yaroshenko O. O.
Published: June 2017

The possibilities and reality of e-medicine problems solving with state-private partnership (SPP) technology in rehabilitation are considered. It is shown that the use of e-medicine is one of the most important levers of improving the quality of medical care during the period of rehabilitation treatment. It is postulated that as the healthcare informatization project are expensive its fast implementation is possible provided the widest use of the principles of SPP. It is believed that mobile medicine is the best example of modern SPP. For effective control of medical care quality the creation of specialized expert and advisory group of specialists is offered. The general principles of e-rehabilitation medicine implementing in the SPP format are defined.
A Structured Review of Antithrombotic Therapy in Peripheral Artery Disease With a Focus on Revascularization
Authors: Hess Connie N. , Norgren Lars , Ansel Gary M. , Capell Warren H. , Fletcher John P. , Fowkes F. Gerry R. , Gottsäter Anders , Hitos Kerry , Jaff Michael R. , Nordanstig Joakim , Hiatt William R.
Published: June 2017

Peripheral artery disease affects >200 million people worldwide and is associated with significant limb and cardiovascular morbidity and mortality. Limb revascularization is recommended to improve function and quality of life for symptomatic patients with peripheral artery disease with intermittent claudication who have not responded to medical treatment. For patients with critical limb ischemia, the goals of revascularization are to relieve pain, help wound healing, and prevent limb loss. The baseline risk of cardiovascular and limb-related events demonstrated among patients with stable peripheral artery disease is elevated after revascularization and related to atherothrombosis and restenosis. Both of these processes involve platelet activation and the coagulation cascade, forming the basis for the use of antiplatelet and anticoagulant therapies to optimize procedural success and reduce postprocedural cardiovascular risk. Unfortunately, few high-quality, randomized data to support use of these therapies after peripheral artery disease revascularization exist, and much of the rationale for the use of antiplatelet agents after endovascular peripheral revascularization is extrapolated from percutaneous coronary intervention literature. Consequently, guideline recommendations for antithrombotic therapy after lower limb revascularization are inconsistent and not always evidence-based. In this context, the purpose of this structured review is to assess the available randomized data for antithrombotic therapy after peripheral arterial revascularization, with a focus on clinical trial design issues that may affect interpretation of study results, and highlight areas that require further investigation.
Memorialization and Presence: Capturing the Legacies of the Young Lords in New York
Authors: Cruz-Malavé Arnaldo Manuel
Published: June 2017

This essay reviews the three-venue exhibition ¡Presente! The Young Lords in New York, which opened in July of 2015 at the Bronx Museum of the Arts, El Museo del Barrio and the Loisaida Center in the Lower East Side. It assesses the three significantly different approaches of these institutions to capturing the visual and performative legacy of the Young Lords, a radical decolonial Nuyorican group of the early 1970s whose political activism engaged communities to transform space through artistic practices. In critically surveying these three approaches, this essay means to explore the cultural, art-historical, and political stakes of exhibitions like ¡Presente!, in which different kinds of loyalty and conceptions of legacy come into contact.
Temporal Phronesis in the Anthropocene
Authors: Wood David
Published: June 2017

The situation in which we find ourselves—of potentially catastrophic global climate change—makes it clear why we need to move beyond a phenomenological approach to time to include evolutionary, historical, material, ecological and personal perspectives. This paper distinguishes ten different ways in which the complexity of time reveals itself to contemporary reflection. These patterns or shapes of time supply interpretive resources for the temporal phronesis needed to navigate the challenge of productively inheriting our many pasts, while thinking through and practically addressing the uncertain future both of our species, and indeed the planet.
Description of a new and two known species of Cephaloboides Rahm, 1928 (Nematoda: Rhabditidae) from India, with discussion on the taxonomy of the genus
Authors: TAHSEEN QUDSIA , HUSSAIN ATHER , AHLAWAT SHIKHA , MUSTAQIM MALKA , KHAN ZAKAULLAH
Published: June 2017

A new species of Rhabditidae, collected from manure, is described and illustrated. Cephaloboides anisospiculus sp. n., an amphimictic species with a 1:1 sex ratio, is characterized by a small to medium-sized body (female: L = 0.5–0.7 mm, a = 13.6–20.0, b = 2.7–3.6, c = 15.4–22.7, c’ = 1.0–1.8, V = 51.2–60.9), finely striated, punctated cuticle; slightly raised labial papillae; stoma with slightly anisomorphic metastegostom; presence of epiptygma; eggs measuring 37–42 x 20–24 µm; slightly protruded vulval lips with cuticular flaps; rectum 16–19 µm long; males with small, stout, slightly arcuate spicules with hood-like capitula and genital papillae in 1/2/(1+3)+2+P configuration; bursa leptoderan, greatly reduced and not enveloping the caudal spike. C. curvicaudatus (Schneider, 1866) Zullini, 1982 is also redescribed, with an emended diagnosis. The present population of C. curvicaudatus shows a few minor differences viz., relatively smaller ‘b’ value, presence of elongate capitula of spicules and strong copulatory muscle bands. Another species, C. parapapillosus (Schuurmans Stekhoven, 1951) comb. n. has been reinstated.
Outcome of hybrid seton placement for the treatment of high complex anal fistulas with and without tube drainage: A prospective comparative study
Authors: Wushouer Abuduwaili , A Ba Bai Ke Re Ma Mu Ti Jiang , Ibrahim Irshat
Published: June 2017

The aim of this study was to investigate the efficacy of treatment for complex anal fistula with cutting hybrid seton combined with tube drainage. A total of 66 consecutive patients with complex anorectal fistulae were divided into two groups: experimental group (group A with 36 patients) underwent cutting hybrid seton placement plus tube drainage and control group (group B with 30 patients) underwent same procedure without tube drainage. Comparison of clinical outcomes between two groups was conducted. The success rate, time for healing of the wound, postoperative pain, and recurrence rate were analyzed. No patient was lost to follow-up. Some major clinical outcomes presented significant differences. Experimental group was superior than the control group in the aspects of success rate, time for healing of the wound, postoperative pain score, and recurrence rate. We can conclude that cutting hybrid seton placement with tube drainage was an effective procedure and valid alternative for complex anorectal fistula with a favorable result on higher healing rate, less postoperative pain, and few impact on the function of sphincter.
The New Berlin
Authors: Hockenos Paul
Published: June 2017

Berlin’s gritty, inventive, do-it-yourself underside attracted droves of young, educated people. But now the tides of gentrification threaten the city’s quirky demeanor. World Policy Institute fellow Paul Hockenos explains how Berlin’s artists and residents are fighting back.
The End of Poverty in China
Authors: Freedman Josh
Published: June 2017

President Xi Jinping has staked his reputation on an ambitious goal: eliminating absolute poverty in China by 2020. Josh Freedman compares two nearby towns in rural Hunan province to reveal the limitations of China’s poverty alleviation campaign.
“Please Don’t Mind Our Tattoos”
Authors: Dreisinger Baz
Published: June 2017

Singapore has transformed its prison system over the last 20 years to focus on rehabilitation, and recidivism rates have fallen by nearly 50 percent. But Baz Dreisinger finds that the government’s push to employ former prisoners is driven more by an abundance of low-level jobs than any moral calculus.
Dignity, Not Deadly Force
Authors: Huq Aziz Z.
Published: June 2017

While domestic security forces around the world equip themselves with military-grade weapons and surveillance technologies, those who research crime have reached a different consensus: To reduce lawbreaking, officers should listen to the accused, show basic courtesy, and exhibit evenhandedness. University of Chicago law professor Aziz Z. Huq concludes that the health of a country’s democracy may even depend on it.
A Body Does Not Just Combust
Authors: Bruce-Jones Eddie
Published: June 2017

Oury Jalloh, an asylum-seeker from Sierra Leone, burned to death chained to a mattress in a German holding cell. Eddie Bruce-Jones, a senior legal lecturer at University of London’s Birkbeck College School of Law, writes that the myriad mistakes in the investigation and prosecution of Jalloh’s case reveal patterns institutional racism that many Germans are unwilling to confront.
Possum Hunting
Authors: Dayan Colin
Published: June 2017

This meditation marks a return to the South and its somewhat raucous racism, a hate so visceral that it can be known only through the tracks of the nonhuman: the possum that suffer in the destruction we have wrought against all species, vegetable and mammalian, everywhere.
Management of Iatrogenic Injury to the Inferior Vena Cava and Right Common Iliac Artery for Drainage of Psoas Abscess
Authors: Mahapatra Sandeep , Ramakrishna Pinjala , Gupta Bhumika , Shetty Naren , Para Muneer Ahmad
Published: June 2017

Iatrogenic simultaneous inferior vena cava (IVC) and iliac vessel injury is a rare entity. Ligation of the IVC in a life-threatening situation is well reported in the literature. Our case demonstrates that such a clinical situation requires optimization of fluid volume and management of sequelae such as deep vein thrombosis.
Complete Shrinkage of the Obliterated False Lumen After Open and Endovascular Chronic Aortic Dissection Stanford Type A Repair
Authors: Samanidis George , Kanakis Meletios , Ieromonachos Constantinos , Stavridis George
Published: June 2017

A 48-year-old man was admitted to our hospital with chronic aortic dissection Stanford Type A. His diagnosis was confirmed by chest multi-detector computed tomography (CT). The patient underwent combined (i.e., hybrid) open and endovascular repair (frozen elephant trunk) in a one-stage operation with moderate hypothermic circulatory arrest and antegrade cerebral perfusion. His postoperative course was uneventful, and he was discharged home on postoperative day 9. At 2-year follow-up, chest CT angiography revealed complete shrinkage of the obliterated false lumen in the distal aortic arch and descending thoracic aorta.
Kesediaan Mendapat Vaksinasi Human Papilloma Virus pada Remaja Putri Di Yogyakarta
Authors: Arifah Kurniawati , Damayanti Wahyu , Sitaresmi Mei Neni
Published: June 2017

Latar belakang. Kanker serviks merupakan keganasan terbanyak keempat pada wanita di dunia. Jumlah kasus baru setiap tahun di Indonesia sebanyak 20.928 dengan kematian 9498. Infeksi Human Papilloma Virus (HPV) risiko tinggi adalah penyebab utama kanker serviks. World Health Organization (WHO) dan Ikatan Dokter Anak Indonesia (IDAI) merekomendasikan vaksinasi HPV untuk wanita 9−14 tahun. Vaksin HPV mulai diberikan melalui bulan imunisasi anak sekolah (BIAS).Tujuan. Mengetahui kesediaan vaksinasi HPV dan hal-hal yang dipertimbangkan dalam menerima vaksinasi pada remaja putri di Yogyakarta.Metode. Penelitian cross-sectional dengan kuesioner anonim pada 319 remaja putri yang dipilih secara cluster random sampling pada September−Oktober 2016. Kriteria inklusi adalah pelajar putri sekolah menengah pertama (SMP) di kota Yogyakarta, bersedia mengikuti penelitian, mendapat persetujuan dari pihak sekolah dan orang tua. Lima dieksklusi karena data tidak lengkap.Hasil. Kesediaan mendapat vaksinasi sebesar 9,9%. Kehalalan dan keamanan vaksin adalah hal yang dipertimbangkan dalam pengambilan keputusan vaksinasi.Kesimpulan. Kesediaan mendapat vaksinasi HPV pada remaja putri masih rendah.
Drugs for the treatment of central diabetes insipidus: historical background and modern opportunities
Authors: Mikhaylova Dar'ya S. , Pigarova Ekaterina A. , Dzeranova Larisa K.
Published: June 2017

Central diabetes insipidus is a severe disease with disturbance of arginine vasopressin secretion, which leads to excretion of large amounts of hypotonic urine. The polyuria-polydipsia syndrome is essential as a clinical presentation and high impact condition. Desmopressin, a synthetic analog of arginine vasopressin, is used to compensate a water-electrolyte balance is available in forms of tablets and intranasal spray. Free drug choice is obligated for proper treatment.
Revisitando viejos esquemas de cooperación transfronteriza en el MERCOSUR: un análisis de la institucionalidad de CRECENEA y su proyección hacia los Estados del Sur de Brasil (CODESUL) // Revisiting old schemes of transboundary cooperation within MERCOSUR. An analysis of the institutional dimension of CRECENEA and its projection towards the Southern States of Brazil (CODESUL)
Authors: Ippolito Daniel
Published: June 2017

Una debilidad estructural de la integración fronteriza en el MERCOSUR se halla en el proceso de construcción social y en el sentido de pertenencia a espacios subregionales al interior del bloque por parte de la ciudadanía. En este artículo se revisita la experiencia de la Comisión Regional de Comercio Exterior del Nordeste y Litoral Argentino (CRECENEA), en sus acciones de cooperación transfronteriza con el Consejo para el Desarrollo del Sur de Brasil (CODESUL). En lo particular, se analiza la dimensión institucional de CRECENEA en las constituciones, leyes y proyectos legislativos de las respectivas provincias que la integran. Se argumenta que a pesar de su inmovilismo, CRECENEA aún preserva gran relevancia para las relaciones argentino-brasileñas, para el MERCOSUR y las políticas de financiamiento de la integración fronteriza sudamericana.
La complementariedad de procesos opuestos. Santa Fe-Paraná en el inicio de la consolidación metropolitana // Complementarity of opposites processes. Santa Fe –Paraná in the beginning of the metropolitan consolidation
Authors: Soijet Mirta , Gramaglia Valeria , Garcia Victoria , Santiago Jaquelina , Poeta Pablo , Aranovich Elina
Published: June 2017

La Región Metropolitana Santa Fe-Paraná, se presenta como un ámbito urbano-rural, que habiendo sobrepasado el millón de habitantes, reconoce como particularidad la duplicación de su ciudad central en dos núcleos  urbanos -Paraná y Santa Fe-, localidades aglomeradas, ciudades perimetrales y pequeñas localidades en el anillo interior definido.En el marco de la investigación en curso se vienen desarrollando estudios que enfocan distintos aspectos de esta conformación urbano-territorial. En este trabajo se presenta un estudio de su dinámica, en función de la disponibilidad de los resultados del Censo 2010.En términos de resultados, este análisis socio-espacial posibilita detectar la evolución de una serie de procesos que ameritan ser profundizados, como la continuidad de un tránsito hacia un modelo de organización con indicios de la integración de nuevas áreas a la aglomeración y, a la vez, la consolidación de algunos subcentros metropolitanos, con capacidad de influencia en la estructura integral.
Perbaikan Konversi Reaksi Melalui Peningkatan Transfer Massa Dan Penggunaan Pelarut Fluorinet
Authors: Suprapto Suprapto
Published: June 2017

Pada penelitian ini, perbaikan konversi reaksi dipelajari dalam sistem reaksi gas-cair oksidasi dimetil benzene. Peningkatan transfer massa dari kedua reaktan dievaluasi kaitannya dengan perbaikan konversi reaksi. Demikian juga penggunaan pelarut organic Fluorinet dipelajari pengaruhnya terhadap peningkatan konversi reaksi. Penelitian secara eksperimental dilakukan di dalam reaktor berpengaduk mekanis pada tekanan atmosferik dan suhu 25 0C untuk oksidasi dimetil benzene (DMB) menggunakan ozon sebagai oksidator. Kedua reaktan gas (DMB dan ozon) dimasukkan secara terpisah dan kontinyu ke dalam reaktor skala laboratorium  berdiameter 100 mm dan tinggi 250 mm. untuk memperoleh peningkatan perpindahan massa, digunakan dua jenis pengaduk berbeda untuk dibandingkan hasilnya terhadap terhadap harga koefisien perpindahan massa dan konversi reaksi, putaran pengaduk dioperasikan dari 0-2000 rpm. Hasil pengamatan menunjukkan bahwa konversi reaksi dapat dinaikkan melalui peningkatan transfer massa. Jika pada saat digunakan  pengaduk 4 blades berdiameter 4 cm diperoleh konversi maksimum sebesar 49%, maka dengan pengaduk 6 blades diameter 6 cm diperoleh konversi lebih tinggi yaitu sebesar 86%. Dalam hal penggunaan pelarut Fluorinet, konversi reaksi meningkat hingga mencapai sebesar 62% sehingga terjadi peningkatan sebesar 24% bila dibandingkan dalam sistem aqueous.Kata kunci : ozon, transfer massa, reaktor berpengaduk, konversi, fluorinet
Peningkatan Mutu Heavy Gas Oil (HGO) Secara Ekstraksi Cair-Cair Dengan Solven Dimethylsulfoxide (DMSO)
Authors: Jos B.
Published: June 2017

Heavy gas oil (HGO) merupakan salah satu bahan dasar untuk bahan bakar mesin diesel/solar yang semakin meningkat kebutuhannya dari tahun ke tahun. Untuk meningkatkan mutu solar salah satu upaya yang dapat dilakukan adalah melalui pengurangan kadar senyawa aromatis dari HGO yang dapat mempengaruhi kualitas penyalaannya. Dalam penelitian ini pengambilan kandungan senyawa C aromatis dalam HGO dilakukan melalui operasi ekstraksi cair-cair dengan menggunakan Dimethylsulfoxide (DMSO) sebagai solven. Selanjutnya HGO yang diinginkan dianalisa sifat-sifat fisisnya. Hasil penelitian menunjukkan semakin besar waktu kontak, temperatur ekstraksi dan perbandingan solven-feed maka akan semakin banyak senyawa aromatis yang dapat terambil, akibatnya harga indeks diesel juga akan semakin meningkat. Kondisi optimum diperoleh jika harga indeks diesel tidak mengalami peningkatan lagi yaitu dengan waktu ekstraksi selama 10 menit pada temperature  40 0C dan perbandingan solven-feed = 1,2.Kata kunci : ekstraksi cair-cair, HGO, senyawa aromatis, solven
Pengaruh Loading Ni Pada Karakter,Aktivitas, Dan Satbilitas Katalis Ni-CeO2/MgO/Al2O3 Untuk Reaksi Oksidasi Parsial Metana
Authors: Purwanto W. W. , Slamet Slamet , Swarandani E.
Published: June 2017

Reaksi oksidasi parsial metana mempunyai potensi menggantikan reaksi reformasi kukus untuk menghasilkan gas sintesis yang selama ini banyak digunakan yang prosesnya membutuhkan energy dan biaya yang besar. Reaksi parsial oksidasi metana merupakan reaksi eksotermis yang  membutuhkan sedikit energy. Loading Ni yang rendah diharapkan dapat mengurangi pembentukan deposit karbon, tetapi tetap memiliki kinerja yang baik karena diameter partikel kecil dan disperse  tinggi. Ni-CeO2/MgO/Al2O3 dengan loading Ni 3,5 dan 10% di@reparasi dengan metode preparasi sol gel-impregnasi. Karakterisasi yang dilakukan adalah, BET, XRD dan chemisorptions. Selanjutnya digunakan pada reaksi oksidasi parsial metana pada temperatur 800 0C, tekanan atmosferik, rasio CH4/O2 sebesar 1,67 dan waktu tinggal 0,2 g.detik/l selama 8 jam reaksi. Loading Ni 5%menunjukkan aktivitas terbaik dengan konversi CH4 sebesar 97,06%, selektivitas CO 73,14%, selektivitas H2 83,38% yield CO 70,99% yield H2 80,93% dan rasio H2/CO 2,28. Uji stabilitas menunjukkan kestabilan selama 48 jam reaksi.Kata kunci : gas sintesis, katalis, oksidasi parsial metana