bluuebunny/crossref_metadata_2025 huggingface dataset:
Testosterone and type 2 diabetes prevention: translational lessons from the T4DM study
Authors: Wittert Gary A , Grossmann Mathis , Yeap Bu B , Handelsman David J
Published: May 2023

Testosterone acting via the androgen receptor, and via aromatisation to oestradiol, an activator of the oestrogen receptor, plays key roles in adipose tissue, bone and skeletal muscle biology. This is reflected in epidemiological studies associating obesity and disordered glucose metabolism with lower serum testosterone concentrations and an increased risk of type 2 diabetes (T2D) in men. Testosterone also modulates erythrocytosis and vascular endothelial and smooth muscle cell function, with potential impacts on haematocrit and the cardiovascular system. The Testosterone for the Prevention of Type 2 Diabetes (T4DM) study enrolled men aged 50 years and over with a waist circumference of 95 cm or over, impaired glucose tolerance or newly diagnosed T2D, and a serum testosterone concentration (as measured by chemiluminescence immunoassay) <14.0 nmol/L. The study reported that a 2-year treatment with testosterone undecanoate 1000 mg, administered 3-monthly intramuscularly, on the background of a lifestyle program, reduced the likelihood of T2D diagnosis by 40% compared to placebo. This effect was accompanied by a decrease in fasting serum glucose and associated with favourable changes in body composition, hand grip strength, bone mineral density and skeletal microarchitecture but not in HbA1c, a red blood cell-dependent measure of glycaemic control. There was no signal for cardiovascular adverse events. With the objective of informing translational science and future directions, this article discusses mechanistic studies underpinning the rationale for T4DM and translational implications of the key outcomes relating to glycaemia, and body composition, together with effects on erythrocytosis, cardiovascular risk and slow recovery of the hypothalamo–pituitary–testicular axis.
Teaching Spanish as a Second Language (SSL) in a Wayúu Indigenous Community in Colombia
Authors: Malaver David , Martínez Manuel , Riveros Camila , Tabla Adriana , Rodríguez Ingrid
Published: May 2023

This study characterizes Spanish as a second language teaching methodology implemented by a group of three Watúu teachers from three schools in La Guajira (Colombia) who described their teaching practices based on their beliefs and experiences. We followed the methodology of a qualitative case study. The data was collected through a questionnaire, field notes, individual interviews, and a focus group. Thereafter, results evidence that their teaching methodology is strongly bonded to the community’s cosmovision, setting harmony between traditional and communicative teaching models: likewise, it considers students’ needs and promotes their responsibility to safeguard their culture.
Pregnancy and Congenital Heart Disease: Moving Beyond the Current Risk Stratification Tools
Authors: Kulasekaran Ajitha , Swan Lorna
Published: May 2023

Women with congenital heart disease have increased risks of complications during pregnancy. Several risk scoring tools have been developed to quantify the likelihood of adverse cardiac outcomes during pregnancy. This article describes how comprehensive pre-pregnancy or early pregnancy counseling needs to go well beyond these risk scores. Non-cardiac risk factors and adverse obstetric and fetal outcomes are vital components of the dialogue between the multidisciplinary team and the patient embarking on, or contemplating, pregnancy.
Interaction of Carthamus oil, chromium picolinate and glyburide in blood glucose and its impact on liver enzymes and lipid profile in diabetes-induced rats
Authors: Silva Gonçalve Gisele Mara , Barros Pedro Paulo , Da Silva Gustavo Henrique , Watanabe Júlia Ferreira , Eisinger André Bernardo de Camargo
Published: May 2023

Introduction: Carthamus oil is a compound that has the potential to be used in numerous applications due to its anti-inflammatory, antioxidant, immunomodulatory and neuroprotective effects. Chromium picolinate has been indicated for the control of insulin resistance. Aim: To evaluate the effect of Carthamus oil (30 mg/kg) and chromium picolinate (5 µg/kg) interaction with oral glyburide in chemically diabetes-induced Wistar rats and its influence on drug therapy. Method: Diabetes mellitus was induced with streptozotocin, and the animals were randomized into experimental groups (n= 6/group), who received gastric gavage treatments for ten days, G1: control, G2: diabetic and received glyburide, G3: diabetic and received the interaction of Carthamus oil and chromium picolinate, G4: diabetic and received the interaction of glyburide, Carthamus oil and chromium picolinate. After the treatment period, fasting blood glucose, post-sucrose blood glucose, total cholesterol and triglyceride levels, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in blood serum were compared, in addition to urine analysis. Results: In this study, the only altered parameters were the post-sucrose blood glucose measurement with the lowest result for G4 (P <0.05), and the ALT measurement, with lower values for G4 (P <0.05) compared to G1. Conclusion: It can be concluded that the unprecedented interaction of Carthamus oil, chromium picolinate and glyburide contributed to the reduction of blood glucose and serum levels of ALT in diabetic rats and is promising for future studies in humans.
SNP fingerprinting and farmer criteria for selection, multiplication, and traceability of cacao in Nicaragua
Authors: Bordeaux Melanie , Castillo Jonny Alonso , Castro Olivas Abner , Jiménez Oswalt R.
Published: May 2023

Introduction. Genetic diversity, registration, and traceability of cacao planting material are the essential tripod to support its sustainable cultivation. In Nicaragua, cocoa planting material is mostly obtained from seeds, which leads to great variability in yield, bean quality, and tolerance to pests and diseases. Farmers, technical staff, development projects, and investors depend on a limited supply of elite trees as a reliable source of genetic material to support new cacao fronts and meet market quality standards. Therefore, the development of a national genetic improvement program and a planting material traceability system in Nicaragua are necessary to improve the sustainability of cacao cultivation. Objective. To evaluate the genetic resources on farms and provide information for future breeding programs, as well as to lay foundation for a national traceability and certification system. Materials and methods. Fourty-nine elite trees selected by farmers in the main producing regions in Nicaragua between 2018 and 2020 were sampled. Ninety-three SNP markers were used to characterize them and resolve their genetic origins. Results. The evaluated cacao trees had a narrow genetic background, mainly composed of hybrids with Amelonado (36 %), Criollo (17 %) and Iquitos (15 %) origins. A set of trees with high genetic diversity that could be incorporated into a selection and breeding program was identified. Conclusion. Fingerprinting with SNP markers was a useful tool for evaluating the genetic links of cultivated cacao and can be used for varietal identity test at the farm level. The study provided the basis for developing both a breeding program and a traceability system of cacao planting material in Nicaragua.
A települési és mezőgazdasági vízgazdálkodás azbeszt okozta kockázati tényezői a krizotil-azbeszt vonatkozásában
Authors: Macher Gergely Zoltán , Torma András , Beke Dóra
Published: May 2023

Az azbesztszálak kimutatására szolgáló vizsgálatok középpontjában a levegőszennyezettségi értékek álltak, de a 21. században felmerült az igény a problémakör kiterjesztésére. Az elmúlt években megjelent nemzetközi tudományos szakirodalmak megcáfolták az évtizedeken át fennálló feltételezést, miszerint az azbeszt csupán a levegőterheltség révén vált ki kockázatot. Vízminőségi és talajminőségi kutatások által teret nyert az azbesztszálak, különösen a krizotilszálak alternatív transzportútjainak vizsgálatát célzó kutatásterület. Annak ellenére, hogy mind a települési, mind pedig a mezőgazdasági vízgazdálkodás potenciálisan érintett a krizotil-azbeszt jelenléte kapcsán, nincs nemzetközi szinten egységes és elfogadott módszer vagy küszöbérték az egyes vízforrások biztonságára vonatkozóan. A kutatások nyilvánvaló korlátja, hogy csekély mennyiségű és minőségű tudás érhető el. Az azbesztszálak megjelenése az egyes vízbázisokban jelentősen megváltoztatja mind a mezőgazdasági, mind a települési vízgazdálkodás környezeti hatásoknak való kitettségéről alkotott eddigi ismereteinket. Az öntözővizzel és a gyűjtött csapadékkal kijuttatott azbesztszálak hatásainak palettája mára túlhaladta a humán- és állategészségügyi hatásokat, immár figyelmet kell fordítani a vegetációs hatásokra is. Annak érdekében, hogy nagyobb betekintést nyerjünk az azbeszttoxicitás növényekre gyakorolt hatásaiba, sokkal több tudományos eredményre van szükség.

Jelen összefoglaló tanulmányban bemutatjuk az azbeszt, különös tekintettel a krizotil azbeszt legfontosabb tulajdonságait, humán-, állat- és növényegészségügyi kockázatait. Rávilágítunk arra, hogy ismereteink rendkívül hiányosak, valamint felhívjuk a figyelmet a települési és mezőgazdasági vízgazdálkodás érintettségének egyes faktoraira, közvetlen és közvetett kockázati tényezőire, valamint arra, hogy ezek miként hatnak az élőlényekre, kiemelt tekintettel a növényekre.
Association of carbapenem and multidrug resistance with the expression of efflux pump-encoding genes in Pseudomonas aeruginosa clinical isolates
Authors: Yousefi Shaghayegh , Nazari Maryam , Ramazanzadeh Rashid , Sahebkar Amirhossein , Safarzadeh Elham , Khademi Farzad
Published: May 2023

Efflux pumps play an important role in the emergence of antibiotic-resistant Pseudomonas aeruginosa strains. The present study aimed to assess the expression of the MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY-OprM efflux pumps in carbapenem-resistant and multidrug-resistant (MDR) P. aeruginosa strains isolated from clinical specimens between June 2019 and January 2022 in Ardabil city. The presence of efflux pump-encoding genes, i.e. mexA, mexC, mexE, and mexY, was assessed using the polymerase chain reaction (PCR) technique in 48 carbapenem-resistant and MDR P. aeruginosa strains. Real-time reverse transcription PCR was employed to evaluate the expression levels of mexA, mexC, mexE, and mexY genes. All 48 carbapenem-resistant and MDR P. aeruginosa strains harbored efflux pump-encoding genes including mexA, mexC, mexE, and mexY according to the PCR results. Overexpression of the MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY-OprM efflux pumps was detected in 75% (n = 36), 83.3% (n = 40), 10.4% (n = 5) and 41.6% (n = 20) of the clinical isolates of P. aeruginosa, respectively. This study revealed that the presence and overexpression of efflux pumps are associated with the emergence of carbapenem-resistant and MDR P. aeruginosa strains. Therefore, research on efflux pump inhibitors of P. aeruginosa will be a worthwhile endeavor to increase the clinical efficiency of available antibiotics and prevent ensuing treatment failure.
Game-Informed Approach to Teaching Request-Making in English
Authors: Taguchi Naoko , Dixon Daniel H.
Published: May 2023

Game-based instruction has been praised as an effective approach to second language (L2) development, as it can provide a low-stakes, fun, and engaging learning environment. However, in designing digital games for L2 learning, it is important to consider how various game designs and mechanics can affect learning gains. In the current study building on Taguchi (2023), a digital game-informed application was developed to teach 118 L2 English learners to identify and produce pragmatically appropriate requests in English. Two versions of the game were developed that differed only in one designed game mechanic: version A allowed learners to see one single reaction from interlocutors after selecting one option from a set of request forms. In contrast, version B allowed learners to see the full range of interlocutor reactions across all items in the same set of request form options. Results indicate that both versions of the game had positive effects on learners’ pragmatics knowledge. The difference in learners’ gains between the two versions of the app had negligible to small effect size (Cohen’s d) differences on both the recognition and production knowledge of the learners. Implications are discussed, offering direction for future research aiming to measure the effects of targeted game mechanics implemented in educational technology
Future-Proofing Language Teaching
Authors: Stickler Ursula , Emke Martina
Published: May 2023

This article explores the future of language teaching in the light of recent developments. It is set against the background of the COVID-19 pandemic, which accelerated technology-related changes within the field. The article outlines factors that have contributed to a shift in the role of language teachers, followed by a depiction of the transformation observed at three distinct points in time during the pandemic. Trends in the changes are drawn from the data with the help of direct quotes, categories of responses, and vignettes representing aggregated language teacher voices. Finally, based on the uncovered trends, we outline reasons for being optimistic about the future of our profession, and provide recommendations for language teachers and language educators to take charge of developments to co-create possible futures for our roles in the profession.
Anxiety and depression symptoms in university students from public institutions of higher education in Brazil during the covid-19 pandemic: a multicenter study
Authors: Barbosa Bruna Carolina Rafael , Paula Waléria de , Ferreira Aline Dayrell , Freitas Eulilian Dias de , Chagas Carolina Martins dos Santos , Oliveira Helian Nunes de , Ferreira Lívia Garcia , Silva Luciana Saraiva da , Vidigal Fernanda de Carvalho , Nobre Luciana Neri , Machado Elaine Leandro , Cardoso Clareci Silva , Meireles Adriana Lúcia
Published: May 2023

This is a multicenter, cross-sectional study carried out with students regularly enrolled in undergraduate courses at eight Brazilian IFES. Data collection was conducted between October 2021 and February 2022 using an online self-completed questionnaire, which addressed sociodemographic and academic characteristics, lifestyle habits, and health conditions. Symptoms of anxiety and depression were assessed using the Depression, Anxiety, and Stress Scale-21 (DASS-21). Variables were analyzed descriptively using frequency distribution and Pearson’s chi-square test. To estimate the prevalence of symptoms of anxiety and depression, the proportion and 95% confidence interval (95%CI) were used. The level of adopted statistical significance was 5%.
ENSINO MÉDIO POLITÉCNICO: LIMITES E POSSIBILIDADES DE UMA POLÍTICA EDUCACIONAL CONTRA-HEGEMÔNICA
Authors: Reis Jonas Tarcísio
Published: May 2023

O presente artigo tem como objetivo analisar a formulação e implementação da reestruturação curricular denominada Ensino Médio Politécnico – EMP, desenvolvida na Rede Estadual de Ensino do estado do Rio Grande do Sul (REE-RS), no período de 2011-2014. A base teórico-metodológica da investigação constituiu-se no materialismo histórico dialético. O banco de dados esteve composto por documentos publicados pela mantenedora para a implementação do EMP, a legislação educacional vigente, entrevistas semiestruturadas realizadas com sujeitos formuladores e implementadores da política, na mantenedora e em quatro escolas do município de Porto Alegre. Para a interpretação e tratamento dos dados utilizamos princípios da Análise Documental. Os resultados apontaram que: a origem dessa política está em fundamentos socialistas e da Educação Popular (EP); com o EMP, o Estado tentou mobilizar-se para formar sujeitos emancipados capazes de transformarem a sociedade; houve embates quanto ao método de implementação pela gestão da SEDUC-RS não ter destinado um tempo maior para debates com as comunidades escolares; houve uma desacomodação e um processo de correlação de forças entre o novo e o velho dentro das escolas, sendo travado de certa forma um enfrentamento aos processos de exclusão escolar. Essa pesquisa ajuda a identificar os meandros dos limites e das possibilidades de uma política de reestruturação curricular que objetivou promover a emancipação humana no Ensino Médio, contra um secular modelo escolar meritocrático, objetivando em último grau a conformação da igualdade substantiva e da justiça social real.
Propriedades periódicas dos elementos químicos e suas breves implicações em sistemas biológicos e nas ciências agrárias
Authors: Vargas Julian Andres Castillo
Published: May 2023

O entendimento do conceito de periodicidade química, permite nortear e definir muitos aspetos relacionados com a estrutura e reatividade dos compostos orgânicos e inorgânicos. Desta forma, este tópico é quase que necessário na disciplina de química geral de qualquer curso de graduação. Assim, esta revisão, tem com finalidade apresentar a evolução, descrição e aplicação em sistemas biológicos e nas ciências agrárias, do conceito de periocidade das propriedades dos elementos químicos. Na primeira parte, realiza-se uma breve abordagem do panorama histórico da tabela periódica dos elementos e como é sua organização básica. Com estas informações, faz-se o desenvolvimento do conceito de periodicidade; posteriormente, são definidas e descritas as tendências para as propriedades periódicas dos elementos, sendo estas, o raio atômico e iónico, afinidade eletrônica, energia ou potencial de ionização e eletronegatividade. Finalmente, exploram-se potenciais implicações das propriedades periódicas dos elementos nos sistemas biológicos e nas ciências agrárias, ilustrando-se, que este conceito pode ser usado para entender a dinâmica atrás destes. É de mencionar, que este documento não pretendem substituir a revisão do conceito de periodicidade química em livros de química geral, é sim auxiliar ao aluno no entendimento deste. Assim, propõe-se ao aluno, que aplique o conceito de periodicidade química em diversas áreas da sua formação acadêmica, principalmente nas associadas às ciências biológicas e agrárias.
Pensamiento Educativo Comunicacional de Paulo Freire en el centenario de su nacimiento 1921 - 2021
Authors:   Ciespal, Dávila Cobo Gissela , Aguirre Alvis José Luis ,   Universidad Católica Boliviana San Pablo, Portugal Escobar Rigliana ,   Universidad Mayor de San Andrés
Published: May 2023

Recuperar el pensamiento de Freire, no es ni puede ser una moda ni intelectual ni sólo de esfera académica, es y se constituye en una necesidad y una demanda permanente, aquella que a cada uno de nosotros nos da el derecho de exigir lo que nos corresponde, de soñar que en lo mediato o futuro se alcancen las relaciones de justicia, inclusión y equidad en las que todos aspiramos realizarnos como auténticos seres humanos. Pensar Freire, y homenajear su nacimiento, y presencia tan fructífera en el pensamiento contemporáneo es recuperar su fuerza humanista y humanizadora de la que todos y cada día necesitamos alimentarnos. Porque desde el campo de la comunicación ¿qué mejor noticia se puede tener para compartir, y así sea base de nuestra transformación, si no es la que anuncia un proyecto liberador y de justicia humana?
Lateral Buckling of Glare for Aerospace Application
Authors: ŞAHİN Burak , YETER Eyüp
Published: May 2023

Glare (Glass Reinforced Aluminium) which consists of fibre metal laminate composite consisting of aluminium and glass is used aerospace structures are supposed to buckling and impact loads. Lateral buckling analyses were made to determine critical buckling loads, and results were compared to Al 2024-T3 in this paper. Weight and load carrying capacity of Glare grades were taken into consideration and the importance of weight to critical load was stated. Numerical works were carried out by starting with Glass and Aluminum then continued for Glare Grades of Glare 2A, Glare 2B, Glare 3A, Glare 3B, Glare 4A, Glare 4B, Glare 5A, Glare 5B, Glare 6A and Glare 6B to estimate buckling load values. Several comparisons were presented for Glare grades based on Al 2024-T3 through paper. Glare 2A, 2B, 3A, 3B, 6A and 6B Grades have lower weight and buckling load values compared to Al 2024-T3. Lower weight is essential for aerospace applications. But optimum weight and load carrying capacity can be selected for intended applications by taking weight and load into consideration at same time. Although Glare grades of 4A 2-1, 4B 2-1, 5A 2-1 and 5B 2-1 having closer weight (17.60g, 17.60g, 19.13g and 19.13g respectively) to Al 2024-T3 (17.31g), higher buckling loads were determined for Glare grades numerically. The best choice for Glare as an alternative to Al 2024-T3 under lateral buckling loading can be decided for point of views of less weight to critical load ratio.
Bi Doped TiO2 as a Photocatalyst for Enhanced Photocatalytic Activity
Authors: ALTIN İlknur
Published: May 2023

This study is based on the preparation of TiO2 and bismuth doped TiO2 (Bi-TiO2) nanoparticles by surfactant-assisted sol-gel approach. The physiochemical characteristics of prepared samples were examined by X-ray diffraction technique (XRD), Fiel emission scanning electron microscopy-energy dispersive analysis (FESEM-EDS), and UV-visible diffuse reflectance spectroscopy (UV-vis DRS). The XRD patterns revealed that the anatase crystal phase was only formed with high crystallinity. The band gap energies were measured to be of 3.11 eV for TiO2-2 and 3.02 eV for Bi-TiO2 by ultraviolet (UV)-visible diffuse reflectance spectroscopy, revealing that doping Bi improves the efficient interactive relation of the catalyst with visible light. Also, EDS results confirm that Bi particles are immobilized on the surface of TiO2 successfully. The activities of the catalysts were tested by photocatalytic degradation of methylene blue (MB) under the visible light. Bi-TiO2 photocatalyst could achieve the best MB degradation percentage of 70.2% after 180 min. of visible irradiation. Additionally, effect of some experimental parameters such as effect of humic acid (HA) and pH has been evaluated as much as reusability of catalyst. The characterization results confirmed the successful and desired preparation of the catalysts. The Bi-TiO2 presented significant visible light response photocatalytic activity for the degradation of MB.
Investigation of the Effect of Hot Fluid on Deformation in T-Shaped Pipes by FSI Method Using Different Material
Authors: KEPEKÇİ Haydar , ASLAN Erman
Published: May 2023

In this study, the high-temperature liquid water flow through the cross-section of a T pipe and the effect of the temperature of the liquid on the pipe material has been investigated. Pipe deformation caused by fluid temperature has been analyzed by the Fluid-structure interaction method. The effect of temperature distribution inside the pipe has been considered as thermal load in the structural analysis of the pipe body. The finite volume method has been used in the study with numerical methods. While k-ε is preferred as the turbulence model, the mesh file created to be used in the analysis contains 200,000 grid cells. For all calculations, the Reynolds number has been set to 3900 and kept constant. The geometry of the T pipe, the fluid passing through the pipe and used the boundary have been constant for the numerical analysis made in the study. The pipe material has been determined as the only parameter that changed. As different pipe materials magnesium, aluminum, copper, steel, concrete, cast iron, and titanium have been used. As a result of the study, thermal strain, total deformation, and directional deformation values have been determined. As a result, it has been determined that the greatest deformation under thermal load is in magnesium pipes, and the smallest deformation is in titanium pipes. It has been observed that the total amount of deformation of the pipe made of magnesium is three times higher than that of the titanium pipe.
Fomento del pensamiento computacional a través de la resolución de problemas en estudiantes de ingeniería de reciente ingreso en una universidad pública de la región andina del Perú
Authors:   Universidad Nacional Autónoma de Tayacaja Daniel Hernández Morillo, Paucar-Curasma Ronald , Villalba-Condori Klinge Orlando ,   Universidad Católica de Santa María, Viterbo Sinche Crispín Fernando ,   Universidad Nacional de Huancavelica, Nolan Jara Jara ,   Universidad Nacional Mayor de San Marcos, Florentino Unsihuay Tovar Roberto ,   Universidad Nacional Mayor de San Marcos, David Rondon ,   Universidad Continental
Published: May 2023

En el artículo, los autores proponen proyectos tecnológicos para desarrollar el pensamiento computacional siguiendo las fases de la resolución de problemas: comprensión del problema, elaboración del plan, ejecución del plan y revisión de la solución. Durante la ejecución de los proyectos, los alumnos realizaron actividades, como elaboración de algoritmos, programación de la placa Arduino y sensores desde una interfaz amigable y lúdica como el mBlock; así como la depuración de programas hasta obtener los resultados esperados; estas actividades realizadas por los alumnos, repercutieron en los procesos cognitivos (razonamiento, toma de decisiones, comprensión del entorno, lógica, etc.), prácticas y perspectivas tecnológicas. Se ha demostrado que existe causalidad entre las habilidades del pensamiento computacional y las fases de la resolución de problemas en un entorno de estudiantes de ingeniería de reciente ingreso a la universidad. Para el análisis de la relación entre las habilidades del pensamiento computacional y resolución de problemas se utilizó la prueba estadística de correlación de Pearson a través del software SPSS.
Influência de Práticas de Gestão do Conhecimento Aplicadas ao Desenvolvimento Ágil de Software
Authors:   Universidade Nove de Julho, Candal Diego Marconi , Gaspar Marcos Antonio ,   Universidade Nove de Julho, Costa Ivanir ,   Universidade Nove de Julho, Magalhães Fábio Luís Falchi de ,   Universidade Federal de São Paulo, Ferreira Ramon Alves ,   Universidade Nove de Julho
Published: May 2023

O objetivo desta pesquisa é identificar a possível influência positiva da aplicação de práticas de gestão do conhecimento (PGC) no desenvolvimento ágil de software (DAS). Esta é uma pesquisa de natureza exploratória-descritiva e de abordagem qualitativa, que realizou revisão da literatura para estabelecer a proposição de pesquisa delineada, que foi refinada e validada a partir de teste de face e aplicação de survey controlado executado com emprego do método Delphi junto a especialistas acadêmicos e profissionais de mercado. Obteve-se consenso de 90,4% entre os especialistas consultados, validando assim a proposição de pesquisa estabelecida. Concluiu-se que as PGC podem influenciar positivamente o DAS. E ainda que as PGC podem facilitar as atividades, incentivar a equipe desenvolvedora de software a compartilhar suas descobertas e que estas são relevantes para as empresas e times de software, possibilitando a geração de benefícios ao serem aplicadas ao DAS destes tipos de empresas e times.
X-linked hypohidrotic ectodermal dysplasia management with removable prosthesis in a pediatric patient. Case Report
Authors:   Javeriana University, Bogota, Colombia, Rodríguez Héctor , Rodríguez José ,   Centro de Estudios Superiores en Ortodoncia, Mexico City, Mexico, de Camargo Maria Acosta ,   University of Carabobo. Department of Pediatric Dentistry, Valencia, Venezuela, Topel Hazel ,   Javeriana University, Bogota, Colombia, Hirschhaut Miguel ,   Policlínica Americana, Caracas, Venezuela
Published: May 2023

Introduction: Ectodermal dysplasia is a rare genetic disorder that affects structures derived from ectoderm such as teeth, hair, nails, and sweat glands. Oligodontia is a common finding that affects the chewing, smiling and self- esteem of these pediatric patients. Case Report: We present a case report of a 7-years-old pediatric patient who consulted with his mother, showing the same condition. The intervention consisted of a removable prosthesis with satisfactory results. Conclusion: The X-linked hypohidrotic ectodermal dysplasia represents a challenge for a pediatric dentist who offers rehabilitation to the patient according to craniofacial development, age, socioeconomic status, and the number of missing teeth.
The Effect of Scaffold Hydroxyapatite derived from Portunus pelagicus Shell on the Expression of Fibroblast Growth Factor-2 (FGF-2) and Bone Morphogenetic Proteins-2 (BMP -2) in the Extraction Sockets of Cavia cobaya
Authors:   Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia., Kridanto Kamadjaja Michael J. , Salim Sherman ,   Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia, Gemiudeas Gigih ,   Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Published: May 2023

Objetive: To determine the expression of Fibroblast Growth Factor (FGF)-2 and Bone Morphogenetic Protein (BMP)-2 after application of scaffold hydroxyapatite from Rajungan crab shell (Portunus pelagicus) in the tooth extraction socket of Cavia cobaya. Material and Methods: This study used a post-test only control group design with 28 Cavia cobaya separated into two groups, control and treatment group. The left mandibular incisor was extracted, and socket preservation was conducted. A hydroxyapatite graft derived from crab shells was mixed with gelatin and eventually turned into a scaffold, which was afterward put into the extraction socket. After 7 days and 14 days, each group was terminated and examined using immunohistochemical staining to observe the expression of FGF-2 and BMP-2. One-Way Anova and Tukey HSD were used to examine the research data. Results: FGF-2 and BMP-2 expressions were observed higher in the group that received hydroxyapatite scaffold at the post-extraction socket than those in the group that did not receive hydroxyapatite scaffold. Conclusion: The application of a hydroxyapatite scaffold from Rajungan crab shell (Portunus pelagicus) to the tooth extraction socket can increase FGF-2 and BMP-2 expression.
Motivational State Does Not Affect All-Out Short Duration Exercise Performance
Authors:   Department of Sport and Exercise, College of Health, Massey University, Palmerston North, 4410, New Zealand, Kuroda Yusuke , Hudson Joanne ,   Applied Sports, Technology, Exercise and Medicine Research Centre, College of Engineering, Swansea University, Swansea, UK, Thatcher Rhys ,   Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK, Legrand Fabien D. ,   Campus du Moulin de la Housse, University of Reims Champagne-Ardenne, Reims, France, Macdermid Paul W. ,   Department of Sport and Exercise, College of Health, Massey University, Palmerston North, 4410, New Zealand
Published: May 2023

Introduction: The preferred motivational state (telic or paratelic), i.e., dominance, has been linked to the type of activity sports people participate in. As such, positive or negative performance may occur if there is a mismatch between the activity and the required state. This study set out to examine the effects of altering telic or paratelic motivational states and thus induce the “misfit effect” in order to quantify the influences on emotions and performance during allout, short duration cycle performance. Methods: Based on paratelic dominance scale (PDS) scores participants completed the Wingate anaerobic test (WAT) on two separate occasions in their preferred and non-preferred motivational state. Special video display method was used to manipulate participants to their non-preferred motivational state and verified via the telic state measure (TSM) test prior to performing the Wingate test (WT). Changes in emotion and stress levels were recorded using the tension and effort stress inventory (TESI) along with heart rate variability (HRV) data obtained from electrocardiogram (ECG). Peak power (PP), mean power (MP) and fatigue index (FI) obtained from the WT were used to assess all-out athletic performance. Results: The main findings show that there was no link between dominant motivational state and anaerobic cycle performance (p>0.05) and that successful manipulation of motivational state (p<0.05) did not influence perceived levels or physiological levels of stress (p>0.05) and did not affect all-out, short duration cycle performance (p<0.05). Conclusion: As such, coaches, support staff and athletes do not have to worry about a particular state in regards to telic or paratelic in an acute time frame, as long as the athlete’s arousal levels and emotional conditions are optimal.
Linearity of the Scale for Mass and Volume within the Air Displacement Plethysmograph (BOD POD): A Methodological Investigation
Authors:   School of Sport and Exercise, Faculty of Applied Sciences, University of Gloucestershire, Gloucester, GL2 9HW, UK, Mills Claire , De Ste Croix Mark ,   School of Sport and Exercise, Faculty of Applied Sciences, University of Gloucestershire, Gloucester, GL2 9HW, UK, James David ,   School of Sport and Exercise, Faculty of Applied Sciences, University of Gloucestershire, Gloucester, GL2 9HW, UK
Published: May 2023

Introduction: In order to maintain the accuracy and reliability for both volume and mass measurements of the air displacement plethysmograph (BOD POD) on a day-to-day basis, quality assurance processes are undertaken. Given the importance of accurate estimation of body mass and body volume in determining body composition, the aim of this methodological investigation was to further examine the calibration approaches and to independently determine both the linearity and reliability of mass and volume measurements throughout the potential measurement range. Methods: Routine calibration procedures for mass (sequentially add known masses ranging from 10-30 kg) range and volume (sequentially add known volume of balloons ranging from 49.900 L to 118.40 L) were conducted using BOD POD model 2000A (Life Measurement Inc. (LMI), Concord, CA, USA). Scatter plots between actual (known) against predicted (measurement) mass and volume values and bias and 95% limits of agreement plots were produced to illustrate the agreement, and paired t-tests to determine significant differences between the volumes. Results: Results revealed that for all mass measurements between 10-30 kg the known mass and measured mass were in agreement. With respect to all volume measurements, the predicted (measured) volume differed from the actual (known) volume by as little as 0.2 L and as much as 0.9 L. There was a difference between actual (known) (mean±SD=65.1±35.9 l) and predicted (measured) (64.7±35.8 L), t9 =6.35 p<0.01. Conclusion: One might question the relevance of only being able to calibrate mass to a maximum of 30 kg, when body mass of adult participants certainly exceed 30 kg. Results from the adapted volume calibration trial using balloons revealed underreporting of predicted (measured) volumes by 0.4 L. However, on the basis of this methodological investigation, it is possible to be broadly confident with the linearity and reliability of both mass and volume measurement outcomes from the BOD POD involving a reasonable level of rigour.
Penentuan Posisi Iradiasi Batu Topaz Dengan Kapsul dan Pengarah Boron Karbida (B4C) di Reaktor RSG-GAS Menggunakan Program BATAN 2-DIFF
Authors: Susanti Fitri
Published: May 2023

PENENTUAN POSISI IRADIASI BATU TOPAZ DENGAN KAPSUL DAN PENGARAH BORON KARBIDA (B4C) DI REAKTOR RSG-GAS MENGGUNAKAN PROGRAM BATAN-2DIFF. Secara rutin iradiasi pewarnaan batu topaz di reaktor RSG-GAS dilakukan pada fasilitas irradiation position (IP). Adanya permintaan target iradiasi lain pada fasilitas yang sama, menyebabkan perlu adanya pengembangan fasilitas iradiasi baru yang dapat digunakan sebagai pengganti fasilitas iradiasi batu topaz. Hal ini dilakukan pada grid berilium yang digunakan sebagai reflektor dalam reaktor. Lamanya waktu paruh akibat interaksi material pengotor teraktivasi dengan neutron termal dalam iradiasi batu topaz merupakan hal lain yang juga perlu dipertimbangkan. Pengembangan teknik iradiasi batu topaz dengan kapsul dan pengarah B4C menjadi solusi karena sifat B4C sebagai penyerap neutron yang baik. Keuntungan dari pengembangan posisi iradiasi pada berilium yang jauh dari daerah bahan bakar menurunkan risiko gangguan distribusi fluk neutron di teras reaktor akibat penggunaan material B4C. Selain itu, penggunaan material B4C akan menurunkan interaksi neutron termal dan memperbesar interaksi neutron cepat dalam pewarnaan batu topaz. Penentuan posisi grid berilium yang baik digunakan dalam iradiasi batu topaz dengan kapsul dan pengarah B4C perlu dilakukan untuk menjamin keselamatan operasi reaktor RSG-GAS. Penelitian dilakukan dengan perhitungan keselamatan neutronik menggunakan program komputer code BATAN-2DIFF (2 dimensi) dan WIMSD5 untuk generasi tampang lintang. Hasil perhitungan menunjukan iradiasi batu topaz dengan kapsul dan pengarah B4C tidak dapat dilakukan pada grid berilium yang berdekatan langsung dengan bahan bakar karena akan menghasilkan gangguan reaktivitas yang besar terhadap teras reaktor. Perubahan reaktivitas terkecil antara kapsul tanpa sekat dan dengan sekat dihasilkan oleh grid berilium H-1 untuk 1 posisi sebesar 0,0485% ∆k/k dan 0,0431% ∆k/k. Pada variasi 2 posisi iradiasi, dihasilkan oleh kombinasi grid A-2 dan J-2 dengan nilai 0,2993% ∆k/k dan 0,2774% ∆k/k. Sedangkan pada variasi 3 posisi, dihasilkan oleh kombinasi grid A-2, J-2 dan H-2 dengan nilai 0,4138% ∆k/k baik pada kapsul tanpa sekat maupun dengan sekat. Selisih nilai perubahan reaktivitas terkecil antara kapsul tanpa sekat dan dengan sekat pada variasi grid 1 dan 2 posisi masing-masing sebesar 0,0054% dan 0,0219% ∆k/k. Sedangkan pada variasi grid 3 posisi menunjukan nilai yang sama. Keseluruhan nilai perubahan reaktivitas masih dibawah nilai batas yang ditentukan untuk pengoperasian reaktor RSG-GAS sebesar 0,5% ∆k/k.  Kata kunci : batu topaz, boron karbida, berilium, BATAN-2DIFF, reaktor RSG-GAS
Implementasi Peraturan Menteri Kesehatan Republik Indonesia Nomor 24 Tahun 2022 Tentang Rekam Medis Terhadap Hasil Pemantauan Kesehatan Pekerja Radiasi di Kawasan Nuklir Serpong
Authors: Yunisca Frida , Chalimah Enny , Sitanggang Leonardo Oloan Agusta
Published: May 2023

Rekam  medis adalah berkas yang berisi catatan dan dokumen tentang identitas pasien, pemeriksaan, pengobatan, tindakan dan pelayanan lain yang telah diberikan kepada pasien, sebagaimana tercantum pada penjelasan pasal 46 ayat (1) Undang-Undang No 29 tahun 2004 tentang Praktik Kedokteran. Perkembangan teknologi digital perlu dimanfaatkan sebesar-besarnya dalam penyelenggaraan rekam medis. Pemerintah melalui Kementerian Kesehatan telah menerbitkan Peraturan Menteri Kesehatan Republik Indonesia Nomor 24 Tahun 2022 Tentang Rekam Medis yang mewajibkan setiap Fasilitas Pelayanan Kesehatan untuk menyelenggarakan Rekam Medis Elektronik. Peraturan ini perlu diimplementasikan untuk pengelolaan data hasil pemantauan kesehatan pekerja radiasi dalam berkas rekam medis. Untuk implementasi perlu disiapkan penyusunan perangkat lunak sistem elektronik yang akan digunakan serta sumber daya manusia pengelola, Hasilnya data kesehatan yang terbangun dapat terintegrasi dan dimanfaatkan dengan sebaik-baiknya dengan tetap memperhatikan keamanan, kerahasiaan data dan informasi, serta memenuhi ketentuan-ketentuan rekam jejak medis.
2021 Annual Report of the Kansas Poison Control Center at The University of Kansas Health System
Authors: Thornton Stephen L , Oller Lisa , White Kathy , Stockdale Robert , Silver Elizabeth
Published: May 2023

Introduction. This is the 2021 Annual Report of the Kansas Poison Control Center (KSPCC) at The University of Kansas Health System. The KSPCC serves the state of Kansas 24-hours a day, 365 days a year with certified specialists in poison information and clinical and medical toxicologists.

Methods. Encounters reported to the KSPCC from 01/01/2021 through 12/31/2021 were analyzed. Data recorded includes caller demographics, exposure substance, nature and route of exposure, interventions, medical outcome, disposition, and location of care.

Results. The KSPCC logged 18,253 total encounters in 2021, including calls from every county in Kansas. A majority of human exposure cases (53.6%) were female. Approximately 59.8% were pediatric exposures (defined as 19 years of age or less). Most encounters occurred at a residence (91.7%) and most were managed there (70.5%). Unintentional exposures were the most common reason for exposures (70.5%).  The most common reported substance in pediatric encounters was household cleaning products (n = 815) and cosmetics/personal care products (n = 735). For adult encounters, analgesics (n = 1,241) and sedative/hypnotics/antipsychotics (n = 1,013) were the most frequently reported. Medical outcomes were 26.0% no effect, 22.4% minor effect, 10.7% moderate effect, and 2.7% major effects. There were 22 deaths.  

Conclusions. The 2021 KSPCC annual report demonstrated that cases were received from the entire state of Kansas. Pediatric exposures remained most common but cases with serious outcomes continue to increase. This report supports the continued value of the KSPCC to both public and health care providers in the state of Kansas.
Nanopore genome sequencing with barcode v1
Authors: not provided phangguanjie
Published: May 2023

The modified version of official protocol using Kappa chemicals
The derived positive meaning of physical activity for people with a diabetic foot ulcer; a scoping review protocol v1
Authors: Rasmussen Birgit
Published: May 2023

Objectives This scoping review aims to explore the derived positive meaning of physical activity in persons with diabetes who have been imposed mobility restrictions due to treatment of a diabetic foot ulcer Background For a person with diabetes mellitus the treatment of a diabetic foot ulcer entails off-loading treatment regimens that put limitations on physical activity. Physical activity is vital for health and provides possibilities for well-being experiences. However, we lack knowledge on physical activity possibilities for persons with diabetic foot ulcers when weight bearing is discouraged. Inclusion Criteria This review will consider studies that investigate physical activity in persons receiving treatment for a diabetic foot ulcer. Given the apparent little number of studies there will be no limitations regarding study design. Methods A search strategy developed in cooperation with a research librarian a search will be applied in EMBASE, MEDLINE, CINAHL, and Google scholar with no restriction on year of publication. Studies published in English, Danish, Norwegian, Swedish, and German will be considered for inclusion. Two reviewers will independently perform study selection. Data will be extracted and presented in pre-defined data charting form. The presentation of data will be a narrative summary of the characteristics and key findings. Findings The findings are expected to be the first step in developing a planned intervention for physical activity for persons with diabetes who has a foot ulcer. Conclusion The conclusion is expected to map the amount of international evidence that additional guidance on physical activity can be built on.
ABOUT QUALITY OF LIFE
Authors: Akhmedova Elena Alexandrovna
Published: May 2023

The quality of space for the life and activities of people, its significance, the structure of the main socio-spatial (including socio-cultural) and material-spatial indicators, the principles of management and development is one of the key topics of research and development of scientists, urban planners and sociologists, ecologists and economists, many interdisciplinary teams around the world in the coming digital age.
SOCIO-CULTURAL APPROACHES AND PRACTICES OF PARTICIPATION IN PROJECTS OF IMPROVEMENT OF YARD TERRITORIES
Authors: Zhogoleva Anna , Polukeeva Tatyana Sergeevna
Published: May 2023

The practices of forming sustainable local communities by the methods of socio-cultural design of common areas differ depending on the level of spatial self-organization of the community: urban level (urban spaces); district level (neighborhood, group of quarters); the level of the secondary common area (yard spaces). Sociocultural approaches to the formation of local communities in the improvement of courtyard areas are based on the practice of participation and include: reliance on grassroots urban initiatives, assistance in resolving territorial conflicts, artistic practices.
HEALTH AS A GUIDELINE FOR CREATING URBAN PLANNING CONCEPTS AND DESIGN SOLUTIONS
Authors: Teryagova Alexandra Nikolaevna
Published: May 2023

The article provides reflections on the relationship between the processes of space formation and human health. Various aspects are considered that must be guided by the formation of a healthy environment based on the five main paths to human well-being formulated in modern psychology. The main provisions for architectural and urban planning research at various design levels - urban planning, architectural, environmental.
CONCERNING THE USE OF THE TERMS "VALUES" AND "COSTS" IN UKRAINIAN PHILOSOPHY
Authors:   Taras Shevchenko national University of Kyiv, Boychenko Mykhailo
Published: May 2023

The philosophical usage of the terms "value as worth" ("vartosti") and "value as costs" ("tsinnosti") in the Ukrainian language has been studied. It is proved that it needs its fundamental and conceptual philosophical clarification. It was revealed, in particular, that the use of the term "value as costs" ("tsinnosti") is unjustifiably and inappropriately widespread in the Ukrainian everyday and scientific language, while the Ukrainian language also has the term "value as worth" ("vartosti") and its derivatives, which denote the sphere of significance, that is basic to any possible values. It is concluded that the Ukrainian language as a language of philosophy has its own potential, which in relation to the category of "worth" and its subordinate concept of "value as worth" turns out to be richer than the potential of older and most recognized languages of philosophy. It is about distinguishing three types of values: unconditional, conditional and negative values. Conditional values as worth in certain research situations can be called values as costs, at the same time it has been proven that unconditional and negative values cannot be values as costs, therefore it is necessary to rethink the use of the terms "value as worth" ("vartosti’) and "value as costs" ("tsinnosti’) not only in the field of philosophy common to all knowledge, but also in special areas of individual humanitarian, social and other sciences. In each such area, such a rethinking can lead to different contextual terminological solutions, but it is proposed to consistently adhere to the general principle of distinguishing between the terms "value as worth" ("vartosti") and "value as costs" ("tsinnosti").