bluuebunny/crossref_metadata_2025 huggingface dataset:
Estudo acústico de tráfego rodoviário rodante sobre pavimentos em concreto asfáltico e com camada porosa de atrito na rodovia BR 158/RS
Authors: Alves Alessandro , Specht Luciano Pivoto , Dresch Fernanda , Santana Echeverria José Antônio
Published: December 2018

O ruído de tráfego resulta do acúmulo de emissões sonoras devido a passagem dos veículos, este é oriundo de várias fontes como o funcionamento do motor, sistema de escape e da interação pneu-pavimento. As duas primeiras fontes de ruído afetam principalmente em baixas velocidades, enquanto que em velocidades acima de 50 km/h o ruído da interação pneu-pavimento é predominante. Estudos demonstram que o ruído ambiental é um dos principais fatores que prejudicam a saúde, sendo o segundo maior causador de doenças, perdendo apenas para a poluição do ar. O objetivo deste estudo é verificar a eficiência da CPA (Camada Porosa de Atrito), em reduzir o ruído nas rodovias. Desta forma, buscou-se avaliar o comportamento acústico de pavimento com revestimento em CPA, executado na rodovia BR 158/RS, e sua comparação com um revestimento tradicional em CA (Concreto Asfáltico) na mesma rodovia. A metodologia utilizada neste estudo segue os requisitos da norma ISO 11819-1 usando o processo de medição de passagem em que um medidor de nível de pressão sonora é instalado ao lado da pista e mede-se o ruído máximo causado pela passagem de no mínimo 180 veículos e suas respectivas velocidades, o que resulta no SPBI (Statistical Pass-by Index). Também foi verificada a influência do ruído de tráfego através da sua avaliação na divisão de frequências de bandas de oitavas e ainda se analisou a influência da pista seca versus pista molhada. Observou-se uma redução no nível de pressão sonora de mais de 6 dB (A) no pavimento com CPA em comparação com o pavimento tradicional avaliado.
Avaliação da relação entre variação de espessura da placa de concreto e presença de defeitos em pavimentos de concreto
Authors: Pereira Deividi Da Silva , De Salles Lúcio Salles , Britto Flavia Campos Macedo , Sanz Diego Sousa Garcia , Khazanovich Lev , Hoegh Kyle
Published: December 2018

A espessura da placa de concreto é a principal incógnita de métodos de dimensionamento de pavimentos de concreto. Pressupõe-se que para condições semelhantes, pavimentos com placas espessas apresentem melhor desempenho do que aqueles com placas delgadas. Entretanto, o efeito da variabilidade da espessura final é pouco discutido. Neste artigo, foram relacionadas informações de avaliações acerca da variabilidade de espessura de pavimentos de concreto com mapas de defeitos na superfície das mesmas placas. Observou-se uma grande variação da espessura do pavimento em ambas as direções. No entanto, o desempenho dos pavimentos (número de defeitos) não depende unicamente da relação entre a espessura de campo e a de projeto. Seções com placas mais espessas do que a espessura de projeto não obtiveram, necessariamente, os melhores desempenhos. Isso se torna importante, considerando que construtoras tendem a construir placas ligeiramente mais espessas, destinadas a evitar deduções de contrato e penalidades. Por outro lado, seções com pequenas deficiências, mas com menor variação de espessura apresentaram um menor número de defeitos, sugerindo o desvio-padrão da espessura (uniformidade de construção) como um parâmetro relevante para o controle de qualidade.
Jatos ou Turboélices: Eficiência no consumo de combustível através de análise envoltória de dados
Authors: Marques Junior Carlos Higino , Borille Giovanna Miceli Ronzani , Mello Luciana Lins de , Eller Rogéria De Arantes Gomes
Published: December 2018

Na indústria aeronáutica, o combustível é um dos mais caros insumos e, com o incessável desejo por redução de custos, as companhias aéreas buscam a otimização de suas frotas através da seleção do conjunto aeronave e motor mais eficiente para as rotas e frequências que operam. Dentro deste contexto, o presente artigo estuda o consumo de combustível de quatro companhias aéreas estadunidenses, sendo: (i) uma com frota composta exclusivamente por jatos regionais, (ii) outra por turboélices, (iii) uma terceira por jatos narrowbodies e (iv) uma quarta com frota mista de jatos regionais e turboélices. A contribuição deste trabalho reside na verificação da eficiência no consumo de combustível através de uma Análise Envoltória de Dados (DEA) tendo como premissas retorno de escala constante (CRS) e variável (VRS). Os resultados indicam que as frotas (ii) e (iii) são mais eficientes que as frotas (i) e (iv) quando se utiliza modelo DEA CRS. A abordagem VRS, no entanto, demonstra que as quatro empresas são igualmente eficientes no consumo de combustível. Ou seja, as frotas (i) e (iv) já apresentariam as melhores práticas, mas enfrentariam problema de escala. No entanto, não é possível afirmar categoricamente que os resultados se devem exclusivamente ao tipo de frota dado os diferentes mercados de atuação de cada empresa.
Análises dos acidentes de trânsito em um trecho de rodovia de pista dupla da BR-116/SP: Abordagem segundo o programa “Pare” e o “Highway Safety Manual – HSM”
Authors: Massaro Camila Mota , Ribeiro Rogerio Lemos , Nardez Nassau De Nogueira , Larocca Ana Paula Camargo , Andrade Michelle
Published: December 2018

Este trabalho propõe uma análise preliminar dos acidentes de trânsito em um trecho de rodovia federal considerada uma das maiores em volume diário de veículos pesados do país, entre os anos de 2011 a 2014. A realização da análise utilizou-se do programa PARE - Programa de Redução de Acidentes - do Ministério dos Transportes (procedimento para o tratamento de locais críticos de acidentes). Posteriormente, foram calculadas as Taxas de Severidade e o índice crítico em um trecho de 10 km da rodovia. A comparação dos índices possibilitou verificar quais trechos apresentaram maior severidade, e consequentemente, quais são os pontos críticos desse trecho. Por fim, utilizou-se o método preditivo do HSM para determinar a quantidade de acidentes futuros na rodovia. Com base nesta análise, o órgão responsável pela rodovia poderá planejar com maior eficiência as futuras intervenções e propor medidas para aumentar a segurança dos usuários da rodovia.
Desempenho da segurança viária na modelagem integrada do uso do solo e transporte-estudo de caso: Projeto Fortaleza 2040
Authors: Cunto Flávio José Craveiro , Sousa Francelino Franco Leite de Matos
Published: December 2018

Por conta de sua importância, observa-se que nos últimos anos há cada vez mais estudos considerando a segurança viária como um componente necessário ao processo de planejamento de transportes. Esse trabalho propõe e aplica um método de estimação do Desempenho da Segurança Viária (DSV) na etapa de avaliação de alternativas do processo de planejamento integrado. O método proposto se baseia na estimação do risco de acidentes por cenário de análise, que incorpore a abrangência e a capacidade de redução de acidentes de cada intervenção. No Projeto Fortaleza 2040, esse método foi aplicado com o auxílio da plataforma de modelagem integrada Tranus. Os resultados indicam uma redução de 22% e de 20% no número de acidentes com vítimas feridas e fatais, respectivamente. Verificou-se também um acréscimo no número de acidentes envolvendo pedestres, por causa do aumento dos deslocamentos a pé.
İbn Kayyim El-Cevziyye'nin Nesih Anlayışı
Authors: KILIÇASLAN Mustafa
Published: December 2018

Bu
makalenin amacı, XIV. yy’da yaşamış önemli müfessirlerimizden biri olan İbn
Kayyim el- Cevziyye’nin (ö. 751/1350), nesih konusundaki görüşlerini
tespit edebilmektir. Bu kapsamda, İbn Kayyim’in nesih meselesindeki yaklaşımı irdelenmiş,
konuyla ilgili olarak getirmiş olduğu özgün yorumlara dikkat çekilmiştir.
Makalenin neticesinde, nesih kavramının zaman içerisinde Kur’an’daki muhtevasından
uzaklaştırıldığı, sahâbe ve tâbiîn terminolojisindeki anlamından koparıldığı
anlaşılmıştır. Buradaki esas problem anlamın seyrindeki sapmadan
kaynaklanmaktadır. Sahâbe nezdinde nesih geniş bir kapsamda
değerlendirilmiştir. İbn Kayyim’e göre nesih çeşitli manalarda ele alınmalıdır.
Örneğin nesih, şeytanın âyetlere katmaya çalıştığı sözlerin geçersiz kılınması,
kastedilen mananın başka bir şeyle karışmayacak şekilde ilgisiz
olanlardan ayrılmasıdır. Ayrıca
nesih, sözün muhkem hale gelmesi gibi bir anlama sahiptir. Nesihle âyet
korunmaktadır. Belki de makalemizin en önemli tespiti budur. Neshin esas
fonksiyonu âyeti iptal etmek değil, onu sağlamlaştırmaktır. Bunun yanında
nesih, katı kalpli kimselerin vesveselerinin ortadan kaldırılması anlamına
gelmektedir.
Tefsir, Kur’an’da Sadece Murad-ı İlâhîyi mi Tespit Eder? Molla Fenârî’nin Tanımı Üzerinden Bir Araştırma
Authors: HOCAOĞLU Mustafa , BÜYÜK Enes
Published: December 2018

Kasik dönemde bazı müfessirler, mantıktaki tanım şartlarına göre Tefsir ilminin tanımını yapmaya çalışmışlardır. Daha önceki bazı tanımları dikkate alarak, onların eksik yönlerini ortaya koymuşlar ve Tefsir’in mahiyetini yansıtan tanım denemeleri yapmışlardır. Tanım, mahiyeti yansıtacağından bu husus, Tefsir’in mahiyetiyle ilgili bazı meseleleri gündeme getirmiştir. Ortaya çıkan sorulardan biri şudur: Tefsir, Kur’an’da sadece muradı-ı ilâhîyi mi tespit eder? Bu soruya verilen cevaba göre farklı tanımlar ortaya çıkmıştır. Meseleyi gündeme getiren Fenârî, soruya evet cevabı vermiş ve sadece telaffuzla ilgili kıraatleri örnek göstermiştir. Bu durumu karşılaması için de Tefsir tanımına bir kayıt yerleştirmiştir. Çalışmada özel olarak Tefsir ve anlamla ilişkili olmayan kıraat meselesi; daha genel olarak da Tefsir’in, Kur’an’ı anlamı dışında da inceleyip incelemeyeceği ve bunun kapsamına nelerin girebileceği meselesi ele alınacaktır.
Nezir Durkilîʼnin Nüzhetüʼl-Ezhânʼı Işığında Kafkasyaʼda İlmî ve Kültürel Durum
Authors: ABDULLAYEV Kamran
Published: December 2018

Tarih ve biyografi alanında yazılan eserlerin Kafkasya bölgesinin öğrenilmesinde önemli yeri vardır. Bu alanda günümüze kadar bulunmuş en son yazılan eserlerden biri Nüzhetüʼ l-Ezhân eseridir. Nezîr Durkilîʼnin tam olarak bitiremediği bu eser, yarım haliyle bile çok önemli kaynaklardan sayılmaktadır. Genel olarak XIX. asırda yaşamış Kafkasyaʼlı âlimlerin hayatlarından bahseden eserde, Sünnî ve Şiî âlimlerin biyografilerine yer verilmekte ve mezheb konusunda bir ayrım yapılmamaktadır. Ayrıca Kafkasya tarihinde unutulmaz bir yeri olan Şeyh Şamilʼin cihâdına ayrı bir bölüm tahsis edilmiş ve bu bölümde Şeyh Şamilʼin biyografisi ile beraber, onun yanında bulunan mücâhid âlimlerin de biyografilerine yer verilmiştir. Eserde ağırlıklı olarak XVIII. ve XIX. asırda yaşamış iki yüz civarında âlimin biyografisine yer verilmiştir.
Zakaria Ouzon’s Thought on Hadith
Authors: Muqtada Muhammad Rikza
Published: December 2018

Departing from the discomfort over the stagnation of intellectual life in Muslim world today, which mainly imprisoned in ”traditional reading” (qirā’ah taqlīdiyyah), Zakaria Ouzon tries to break the tradition by restoring religious texts into historical frame. For him, the ultimate authority of revelation belongs only to the Qur’an, while other religious texts are the products of ijtihād and very open to criticism and more dynamic. Hadith and its sciences are very dynamic. Therefore, Ouzon looks at the hadits from different frame. For him, the hadits is the Prophet’s reports on events that happened to the Prophet and his interaction with his companions. As the logical consequence, Ouzon offers the hadith criticism models with an emphasis on the historicity and rationality of the content. The knowledge of hadith not only limited to the past as the truth was improsined within the text, but it is necessary to contextualize the hadith. Therefore, the hadith sciences is very dependent on the dynamics of social and humanities sciences along with scientific knowledge, so that the truth that is brought also becomes local and temporal entity.[Berangkat dari kegelisahan atas fenomena kejumudan nalar umat Islam saat ini yang terbiasa dengan pembacaan tradisional (qirā’ah taqlīdiyyah), Zakaria Ouzon berusaha mendobrak tradisi dengan mengembalikan teks-teks agama pada sisi historisitasnya. Baginya, yang memiliki otoritas kewahyuan hanyalah al-Qur’an, sementara teks-teks agama lainnya bersifat  ijtihādī sehingga ia sangat terbuka atas kritik dan lebih dinamis. Hadis dan Ilmu Hadis merupakan wilayah yang sangat dinamis. Karena itu Ouzon memandang Hadis dari episteme yang berbeda. Baginya, Hadis merupakan laporan-laporan sahabat Nabi atas peristiwa yang terjadi pada diri Nabi dan interaksinya dengan sahabat-sahabatnya. Konsekuensi logisnya, Ouzon menawarkan model-model kritik hadis dengan penekanan pada sisi historisitas dan rasionalitas teks. Pengetahuan hadis tidak sekedar pengetahuan masa lalu dengan atribut kebenarannya ada pada teks, tetapi upaya kontekstualisasi hadis adalah keharusan pengetahuan. Karena itu pengetahuan hadis sangat bergantung pada dinamika pengetahuan sosial humaniora dan pengetahuan sains modern sehingga kebenaran yang diusung juga bersifat lokal dan temporal.]
Respuesta fisiológica de especies arbóreas al anegamiento. Nuevo conocimiento sobre especies de interés en el arbolado urbano de Bogotá
Authors: Moreno Echeverry Darwin Leonel , Useche Rodríguez Diana Carolina , Balaguera López Helber Enrique
Published: December 2018

Los efectos del calentamiento global en las zonas urbanas hacen preponderante el estudio de especies arbóreas en diferentes condiciones de estrés abiótico, como el anegamiento. En este estudio se analizó el comportamiento fisiológico de seis especies nativas con cuatro niveles de anegamiento, determinando el estado hídrico, el comportamiento fotosintético y la pérdida de electrolitos. De acuerdo a los parámetros evaluados, se recomienda establecer Quercus humboldtii y Ficus tequendamae en zonas con altas precipitaciones y con tendencia al anegamiento debido a la tolerancia que se evidenció. Esto permite que estas zonas en Bogotá mantengan el arbolado urbano bajo escenarios de cambio climático. La estabilidad de las membranas celulares y la eficiencia máxima fotosintética del fotosistema II pueden ser usados como marcadores de tolerancia a condiciones de anegamiento en árboles.
Reliability of Trigonometric Transform-based Multi-Carrier Scheme
Authors: Mustafa Samah A.
Published: December 2018

This work is looking for a new physical layer of a multi-carrier wireless communication system to be implemented in low complexity way, resorting to suitable fast transform. The work presents and assesses a scheme based on Discrete Trigonometric Transform with appending symmetric redundancy either in each or multiple consecutive transformed blocks. A receiver front-end filter is proposed to enforce whole symmetry in the channel impulse response, and bank of one tap filter per sub-carrier is applied as an equalizer in the transform domain. The behaviour of the transceiver is studied in the context of practical impairments like fading channel, carrier frequency offset and narrow band interference. Moreover, the performance is evaluated in contrast with the state of art methods by means of computer simulations, and it has been found that the new scheme improves robustness and reliability of communication signal, and record lower peak to average power ratio. The study demonstrates that front-end matched filter effectively performs frequency synchronization to compensate the carrier frequency offset in the received signal.
Factors Controlling the Development of Wine-Glass Forms in the Mountains of the Kurdistan Region, Iraq
Authors: Sissakian Varoujan K. , Othman Arsalan A. , Shihab Ahmed T.
Published: December 2018

The northern and northeastern parts of Iraq are mountainous areas and rugged topography with different erosional and morphological forms; among them are the wine-glass (erosional cirques) forms. They are developed in different shapes, sizes, and depths. In the outlets of the wine-glass forms; usually, alluvial fans are formed. The studied area is characterized by the presence of long and narrow anticlines with NW–SE trend that changes westward to E–W trend. The Cretaceous carbonate rocks form the main carapace of the majority of the mountains; however, locally Paleogene and/or Jurassic rocks form the carapace. In the core, rocks down to Devonian are exposed. In those anticlines where only Cretaceous rocks are exposed, no or very rarely wine-glass forms are developed. This is attributed to the Cretaceous carbonate rocks, which exist in huge thicknesses in many formations, with thickly bedded to massive nature and very hard erosion resisting rocks. Tens of the existing wineglass forms are studied to indicate the factors that control their development, which are the type of exposed rocks, their thicknesses, and hardness. To perform the aim of this study, different satellite imagery with different resolutions was used; besides using GIS technique and field check to improve the acquired date.
Finansal Raporlama Hilelerinin Saptanmasında Kullanılan Araçların Önem Derecelerinin Bağımsız Denetçilerin Bakış Açılarıyla Değerlendirilmesi
Authors: DEMİR Mehmet , ARSLAN Öznur
Published: December 2018

Bu çalışmanın amacı öncelikle, bağımsız denetçilerin bakış
açılarıyla finansal raporlama hilelerinin ortaya çıkarılmasında hangi
araçların/uygulamaların önemli olduğunu belirlemektir. Ayrıca denetim
hizmetinin karşılığı olan ücretin doğrudan işletmeden alınmasının bağımsızlık
sorununa yol açıp açmadığı ve denetçi bağımsızlığının güçlendirilmesi için
nelerin yapılmasının uygun olacağı da saptanmak istenmiştir. Bu amaçları
gerçekleştirmek için bağımsız denetim şirketlerinde çalışan bağımsız
denetçilerden 300’ünün üzerinde 2017 Haziran-Ağustos döneminde bir anket
uygulanmıştır. Elde edilen veriler SPSS 22 paket programı ile analize tabi
tutulmuştur. Analiz sonucunda, bağımsız denetçilere göre finansal raporlama
hilelerinin ortaya çıkarılmasında en önemli üç aracın/uygulamanın sırasıyla
bağımsız denetim, iç denetim ve iç kontrol ortamı ve sistemleri olduğu saptanmıştır.

Denetim ücretinin doğrudan işletmeden alınmasının bir bağımsızlık
sorununa yol açtığına inananların oranı %27,8 bulunmuştur. Denetim ücretinin
ödenme şekli açısından bağımsızlığı güçlendirecek önerilerden “Müşteri
işletmelerden yapılacak kesintilerle oluşturulan bir havuz hesabından”
önerisinin %46,97 oranıyla en iyi öneri olduğu bulgusu elde edilmiştir.
Bağımsız denetçilerin %87,7’sinin hile risk değerlendirmesi için “Kontrol
Çizelgelerini” tercih ettikleri belirlenmiştir.
KEBUTUHAN RUANG TRANSISI DI KAWASAN CBD KOTA BANDUNG BERDASARKAN PREFERENSI DAN PERSEPSI PEJALAN KAKI
Authors: Utami Witanti Nur , Indradjati Petrus Natalivan , Poerbo Heru Wibowo
Published: December 2018

City center is an urban place which always attract people either for visit or work purpose. Those activities generates pedestrian traffic that needs to be managed by providing transition space. So far, the need of transition space in urban Indonesia has not been clearly regulated and considered related to the design of transition space that can be use by pedestrians in the city center. Furthermore, there are no studies related to the aspects that need to be considered in the design needs of urban transition space from pedestrians point of view. The study aims to design transition space requirements in the CBD through a visitor and worker pedestrian preferences approach.  Moreover, physical aspect / design element that need to be considered are conditions, potentials and factors that affect the existence of transition place. Field study and analysis found that visitor and workers found in Bandung central area mostly prefer pedestrian mall type as a transition space. Furthermore, the design principles for transition space consists of component of form, access and the character of space.
Ocena efektywności procesu dyplomowania na studiach pierwszego stopnia w polskich publicznych uczelniach technicznych
Authors: Szuwarzyński Andrzej
Published: December 2018

W artykule przedstawiono analizę i ilościową ocenę funkcjonowania 18 polskich uczelni technicznych uwzględniającą dwa podstawowe problemy: rezygnację ze studiów w trakcie pierwszego roku oraz wskaźniki ukończenia studiów w nominalnym czasie. Do oceny efektywności procesu dyplomowania wykorzystano prostą metodę wskaźnikową oraz nieparametryczną metodę Data Envelopment Analysis (DEA). Ocenę przeprowadzono dla studiów pierwszego stopnia prowadzonych w formie stacjonarnej i niestacjonarnej. Na podstawie prostych wskaźników dokonano wstępnej oceny zjawiska. W modelu DEA uwzględniono po stronie nakładów liczbę studentów rozpoczynających studia w 2011 roku, liczbę nauczycieli akademickich oraz całkowitą liczbę studentów pierwszego stopnia. Po stronie rezultatów uwzględniono liczbę absolwentów z roku 2015 oraz liczbę osób, które zrezygnowały po pierwszym roku studiów. Model ten pozwolił na stworzenie rankingu oraz obliczenie pożądanych wartości zmiennych uwzględnionych w analizie, dla uczelni nieefektywnych. W interpretacji wyników uwzględniono wcześniej zdefiniowane wskaźniki.
Transformation of a copula using the associated co-copula
Authors: Girard Stéphane
Published: December 2018

We investigate the properties of a new transformation of copulas based on the co-copula and an univariate function. It is shown that several families in the copula literature can be interpreted as particular outputs of this transformation. Symmetry, association, ordering and dependence properties of the resulting copula are established.
Self-Referential Memory Encoding and Mind- Wandering in Younger and Older Adults
Authors: Lipitz Sarah R. , Liu Xiaodong , Gutchess Angela
Published: December 2018

Self-referencing, the relating of information to oneself, is a successful encoding strategy that improves memory across the lifespan. Mind-wandering, the shifting of thoughts from a task to selffocused information, is characterised by decreased cognitive performance and is reported by older adults less frequently than by younger adults. In the present study, we investigated a hypothetical relationship between mind-wandering and self-referential memory and whether this relationship decouples in healthy aging. Younger and older adults rated adjectives on how descriptive they were of themselves, Albert Einstein or assessed the commonness of the adjective. Participants were interrupted during the encoding task with randomly timed mind-wandering prompts and then completed a surprise free recall test. Results replicated prior demonstrations of enhanced memory for self-referenced information, whereas age and self-focus decreased reports of mind-wandering. In terms of effects of interest, we found that encoding condition as well as age impacted the number of words recalled and reports of mind-wandering. However, a single mechanism does not appear to account for both of these effects, and there was no compelling evidence for age differences in the relationships amongst the factors. Future research should further examine the relationships amongst self, memory, and mind-wandering across the lifespan.
Distributed Strain Sensing to Study a Composite Liner for Cast Iron Water Pipe Rehabilitation
Authors: Adebola Titilope O. , Hoult Neil , Moore Ian D.
Published: December 2018

The use of cured-in-place pipe lining systems for the rehabilitation of cast iron water pressure pipe has grown significantly in the past 20 years. With limited information on the performance of these lining systems in service, strain measurements are needed to evaluate theoretical findings about three-dimensional strength limits. The application of distributed optical fiber sensing to study the properties of a polymer composite liner was investigated in this research. Polyimide optical fibers were installed into flat liner coupons fabricated in the laboratory, and the specimens were subsequently tested in uniaxial tension and four-point bending. Using optical frequency domain reflectometry, Rayleigh backscatter was monitored from preinstalled optical fiber sensors and strains of up to 4,000 με were obtained. Comparisons between experimental optical fiber measurements and results obtained from conventional strain measurement techniques (i.e., extensometer and crosshead displacement) showed a strong correlation with an average difference of 3 % in four-point bending and 6 % in tension. However, the orientation and diameter of the composite fiber reinforcements were observed to affect distributed sensing performance.
Mining the Student Dropout in Higher Education
Authors: Hsu Ching-Wen , Yeh Ching-Chiang
Published: December 2018

Higher technological and vocational education (TVE) has served an important role in the long-term progress and industrial development of Taiwan. However, the high dropout rates in higher TVE are a challenging task for policy makers. This study is a first to propose a hybrid approach that combines both k-means and rough set theory for mining the dropout knowledge among student dropout. An empirical case of student dropout is based on the industrial-academic cooperation (IAC) education of higher TVE in Taiwan. The results of knowledge extraction from the proposed approach are illustrated as knowledge patterns/rules and clusters to provide better understanding of the reasons for or factors influencing student dropout.
Aberrant Somatosensory Processing and Connectivity in Mice LackingEngrailed-2
Authors: Chelini Gabriele , Zerbi Valerio , Cimino Luca , Grigoli Andrea , Markicevic Marija , Libera Francesco , Robbiati Sergio , Gadler Mattia , Bronzoni Silvia , Miorelli Silvia , Galbusera Alberto , Gozzi Alessandro , Casarosa Simona , Provenzano Giovanni , Bozzi Yuri
Published: December 2018

Overreactivity and defensive behaviors in response to tactile stimuli are common symptoms in autism spectrum disorder (ASD) patients. Similarly, somatosensory hypersensitivity has also been described in mice lacking ASD-associated genes such asFmr1(fragile X mental retardation protein 1).Fmr1knock-out mice also show reduced functional connectivity between sensory cortical areas, which may represent an endogenous biomarker for their hypersensitivity. Here, we measured whole-brain functional connectivity inEngrailed-2knock-out (En2−/−) adult mice, which show a lower expression ofFmr1and anatomical defects common toFmr1knock-outs. MRI-based resting-state functional connectivity in adultEn2−/−mice revealed significantly reduced synchronization in somatosensory-auditory/associative cortices and dorsal thalamus, suggesting the presence of aberrant somatosensory processing in these mutants. Accordingly, when tested in the whisker nuisance test,En2−/−but not WT mice of both sexes showed fear behavior in response to repeated whisker stimulation.En2−/−mice undergoing this test exhibited decreased c-Fos-positive neurons (a marker of neuronal activity) in layer IV of the primary somatosensory cortex and increased immunoreactive cells in the basolateral amygdala compared with WT littermates. Conversely, when tested in a sensory maze,En2−/−and WT mice spent a comparable time in whisker-guided exploration, indicating that whisker-mediated behaviors are otherwise preserved inEn2mutants. Therefore, fearful responses to somatosensory stimuli inEn2−/−mice are accompanied by reduced basal connectivity of sensory regions, reduced activation of somatosensory cortex, and increased activation of the basolateral amygdala, suggesting that impaired somatosensory processing is a common feature in mice lacking ASD-related genes.

SIGNIFICANCE STATEMENTOverreactivity to tactile stimuli is a common symptom in autism spectrum disorder (ASD) patients. Recent studies performed in mice bearing ASD-related mutations confirmed these findings. Here, we evaluated the behavioral response to whisker stimulation in mice lacking the ASD-related geneEngrailed-2(En2−/−mice). Compared with WT controls,En2−/−mice showed reduced functional connectivity in the somatosensory cortex, which was paralleled by fear behavior, reduced activation of somatosensory cortex, and increased activation of the basolateral amygdala in response to repeated whisker stimulation. These results suggest that impaired somatosensory signal processing is a common feature in mice harboring ASD-related mutations.
Developmental Requirement of Homeoprotein Otx2 for Specific Habenulo-Interpeduncular Subcircuits
Authors: Ruiz-Reig Nuria , Rakotobe Malalaniaina , Bethus Ingrid , Le Menn Gwenaëlle , Huditz Hannah-Isadora , Marie Hélène , Lamonerie Thomas , D'Autréaux Fabien
Published: December 2018

The habenulo-interpeduncular system (HIPS) is now recognized as a critical circuit modulating aversion, reward, and social behavior. There is evidence that dysfunction of this circuit leads to psychiatric disorders. Because psychiatric diseases may originate in developmental abnormalities, it is crucial to investigate the developmental mechanisms controlling the formation of the HIPS. Thus far, this issue has been the focus of limited studies. Here, we explored the developmental processes underlying the formation of the medial habenula (MHb) and its unique output, the interpeduncular nucleus (IPN), in mice independently of their gender. We report that theOtx2homeobox gene is essential for the proper development of both structures. We show that MHb and IPN neurons requireOtx2at different developmental stages and, in both cases,Otx2deletion leads to disruption of HIPS subcircuits. Finally, we show that Otx2+neurons tend to be preferentially interconnected. This study reveals that synaptically connected components of the HIPS, despite radically different developmental strategies, share high sensitivity toOtx2expression.

SIGNIFICANCE STATEMENTBrain reward circuits are highly complex and still poorly understood. In particular, it is important to understand how these circuits form as many psychiatric diseases may arise from their abnormal development. This work shows thatOtx2, a critical evolutionary conserved gene implicated in brain development and a predisposing factor for psychiatric diseases, is required for the formation of the habenulo-interpeduncular system (HIPS), an important component of the reward circuit. Otx2 deletion affects multiple processes such as proliferation and migration of HIPS neurons. Furthermore, neurons expressingOtx2are preferentially interconnected. Therefore,Otx2expression may represent a code that specifies the connectivity of functional subunits of the HIPS. Importantly, theOtx2conditional knock-out animals used in this study might represent a new genetic model of psychiatric diseases.
Prilog poznavanju kasnogotičke skulpture u Rijeci: prijedlog za Leonarda Thannera i nepoznata grupa Oplakivanje Krista
Authors: Pintarić Mario , Tulić Damir
Published: December 2018

U članku se raspravlja o kasnogotičkoj skulpturi Pietà koja se nalazi u stalnom postavu Pomorskog i povijesnog muzeja Hrvatskog primorja u Rijeci. Riječ je o drvenom kipu sa slabo sačuvanim tragovima polikromije i pozlate. Skulptura je nađena 1920. na tavanu župne crkve Marijinog Uznesenja u Rijeci. O kipu je pisala Vanda Ekl te ga je datirala u kraj treće četvrtine 15. stoljeća, ne odredivši mu pobliže krug nastanka ni povijest. Putem stilske analize, kao i niza tipoloških i oblikovnih podudarnosti, Riječku Pietà moguće je povezati s drvorezbarom Leonardom Thannerom iz bavarskog Landshuta aktivnom u Furlaniji u drugoj polovici 15. stoljeća. Za komparaciju s kipom u Rijeci ključna je Thannerova drvena polikromirana grupa Oplakivanja Krista iz crkve Santa Maria della Fratta u San Daniele del Friuli nastala 1488. godine. Na temelju arhivskih podataka rekonstruira se povijest te izvorni smještaj kipa. U tekstu se po prvi puta objavljuje skulptura Oplakivanja Krista recentno pronađena u Rijeci, a može se povezati uz radionicu ili krug furlanskog kipara Giovannija Martinija i okvirno datirati u prvu četvrtinu 16. stoljeća.
Uništeni talijanski spomenik „Ara ai Caduti Dalmati” u Zadru
Authors: Dragoni Patrizia , Mlikota Antonija
Published: December 2018

Članak se bavi spomenikom koji je bio posvećen poginulim Dalmatincima u Prvom svjetskom ratu, a bio je podignut 1928. godine u hrvatskom priobalnom gradu Zadru. Spomenik je posve uništen tijekom bombardiranja grada i raščišćavanja ruševina nakon Drugoga svjetskog rata. Članak je nastao kao rezultat zajedničkih istraživanja provedenih u Italiji i Hrvatskoj, a u njemu predstavit će se projekt spomenika, ključne osobe zadužene za njegovu provedbu, te pobliže pojasniti veza između četiri antičke carske skulpture (danas smještene u Arheološkom muzeju u Zadru) i nekadašnjeg talijanskog spomenika u Zadru, kao i pojašnjenje zašto neki od starijih građana Zadra još uvijek određeni dio povijesne jezgre grada nazivaju Monumento.
Feministički iskazi u kritičkoj recepciji skupnih izložbi hrvatskih umjetnica
Authors: Šeparović Ana
Published: December 2018

U ovome radu promatrat će se diskurs recepcije tri vala skupnih izložbi hrvatskih umjetnica tijekom XX. stoljeća s fokusom na feminističke strategije zagovaranja i osnaživanja ženske umjetnosti. Razmatrani korpus tekstova obuhvaća likovne kritike koje su pratile prvu skupnu – Intimnu izložbu održanu u okviru Proljetnoga salona 1916., potom izložbe Kluba likovnih umjetnica (1928. –1940.), sve do izložbi u čast Osmoga marta (1960. –1991.). Te su izložbe, iako su se odvijale u različitim uvjetima i društveno-političkim kontekstima, bile generator javne rasprave o umjetničkom stvaralaštvu žena, pa iako su provocirale mizogine i antifeminističke iskaze, kao reakcija na njih javljaju se i otvoreno feministički glasovi. Upravo ti feministički iskazi utjecali su na stvaralačku samosvijest u žena, ali i polako pripitomljavali društvo privikavanjem na prisutnost ženskih umjetnica, čime su sudjelovali u postupnom suzbijanju stereotipa i predrasuda te polaganom rastakanju dominantne patrijarhalne matrice na području hrvatske likovne umjetnosti XX. stoljeća.
„Relacijska forma” kao umjetnički jezik: pristupi i prijepori
Authors: Rukavina Katarina
Published: December 2018

Rad se bavi mapiranjem i teorijskim konceptualiziranjem polemika vezanih uz „relacijsku formu”. Pri tome ne predstavlja pokušaj pacifikacije različitih pozicija niti zauzimanja „strane” u polemikama, već se temelji na studiji koncepata (concept-based metodology) koja služe kao pomagala boljem razumijevanju objekta istraživanja. Premda je forma suvremene umjetnosti, bilo da je čine procesi ili postupci, prema tradicionalnom shvaćanju „razbijena”, cilj rada je ispitati suprotno. U prvom dijelu analizirat će se pojam „relacijske forme” te diskursi vezani uz njezino artikuliranje. U drugom se dijelu istražuju tehnike i postupci odnosno strategije konceptualnih avangardi 1990-ih i 2000-ih. Zaključno se razmatraju napori, prijepori i mogućnosti umjetnosti u proširenom polju relacijskih praksi. Istraživanje će poslužiti za pobliže određenje ontološkog statusa suvremenih umjetničkih formi.
Slika kao polje introspekcije
Authors: Župan Ivica
Published: December 2018

Opus Sunčanice Tuk čine pulsirajuće, nemirne fakture, koju čine u nizove sistematizirani okomiti, uvijek različiti potezi, iz kojih se, zbog njihove nervature i pulsiranja, nerijetko cijedi boja. Njezin je opus uistinu suptilna i kultivirana samoanaliza, sublimni psihogram, nešto što autoričino duševno stanje pretvara u neposredan ljudski trag, pogodan, kako kaže slikarica, „za najdublje kontemplativno poniranje” u tajne njezina nedvojbeno duhovno bogata bića, za očitovanje njezine složene psihičke konstelacije i duševnih tenzija, neuralgičnosti, ne kažemo drame koju autorica, čini nam se, sveudilj proživljava. Više solilokvij nego dijalog sa svijetom, šifrirani i maskirani jezik, dvosmislenost, nedorečenost, govor u natuknicama koje neće svatko razumjeti, ipak potresu i isprovociraju motritelja.
Role of Organizational Citizenship Behavior (OCB), Perception of Justice and Job Satisfaction on Employee Performance
Authors: Hidayah Siti , Harnoto Harnoto
Published: December 2018

This study aims to investigate the role of organizational citizenship behavior (OCB) on employee performance through perception of justice and job satisfaction of employees. Sample for the present study consisted of 309 employees working in Baitul Maal Wat Tamwil (BMT) of Central Java. Result of regression analysis indicated that perception of justice was positively and significantly related to job satisfaction and organizational citizenship behavior (OCB), whereas job satisfaction was found to be related positively and significantly with organizational citizenship behavior (OCB). Then, also perception of justice, job satisfaction, and organizational citizenship behavior (OCB) were found to be related positively and significantly with employee performance. Based on these results, it can be interpreted that perception of justice, job satisfaction, and organizational citizenship behavior (OCB) are valuable components of an organization. These components can become important factors to improve employee and organizational performance. Theoretical and practical implications of the result are discussed.
Privatization and Firm Performance: a Study of Indonesia’s State-owned Enterprises
Authors: Soejono Fransiska , Heriyanto Heriyanto
Published: December 2018

This study aimed to examine the differences in the company’s performance before and after privatization. This study also examined the differences in performance before and after privatization on specific sub-samples of the data which is based on privatization method. Government policy of carrying out the privatization toward SOEs is still pro and contra. Various Privatization methods offer its weaknesses and strengths. There are different opinions on the best method for SOE privatization in Indonesia. The population is all companies which execute the privatization method. Secondary data were used namely financial statement which was taken from the Indonesia Stock Exchange, and the company’s website. Data were analyzed using normality test data. In addition, the paired t-test by using normally distributed data assumption was used to test the hypothesis. The results showed that Direct method privatization positive and significant changes in measuring Total Asset Turnover. Performance conducted Privatization through the capital markets showed different results. Test on the capital market method of data showed a similar effect with an analysis on the entire data (without separating the privatization method used) that occur significant performance degradation, especially in measuring Total Asset Turnover, Debt Ratio and Return On Equity. Conducted Management/ Employee Buy-Out (MBO) privatization implied a substantial reduction in measuring Debt Ratio and Return on Equity Performance.
Plasticity of Lh cells caused by cell proliferation and recruitment of existing cells
Authors: Fontaine Romain , Ager-Wick Eirill , Hodne Kjetil , Weltzien Finn-Arne
Published: December 2018

Luteinizing hormone (Lh) and follicle-stimulating hormone (Fsh) control reproduction in vertebrates. Using a transgenic line of medaka, in which green fluorescent protein expression is controlled by the endogenous lhb promotor, we studied development and plasticity of Lh cells, comparing juveniles and adults of both genders. Confocal imaging and 3D reconstruction revealed hypertrophy and hyperplasia of Lh cells in both genders from juvenile to adult stages. We show that Lh cell hyperplasia may be caused by recruitment of existing pituitary cells that start to produce lhb, as evidenced by time lapse recordings of primary pituitary cell cultures, and/or through Lh cell proliferation, demonstrated through a combination of 5-bromo-2′-deoxyuridine incubation experiments and proliferating cell nuclear antigen staining. Proliferating Lh cells do not belong to the classical type of multipotent stem cells, as they do not stain with anti-sox2. Estradiol exposure in vivo increased pituitary cell proliferation, particularly Lh cells, whereas pituitary lhb and gpa expression levels decreased. RNA-seq and in situ hybridization showed that Lh cells express two estrogen receptors, esr1 and esr2b, and the aromatase gene cyp19a1b, suggesting a direct effect of estradiol, and possibly androgens, on Lh cell proliferation. In conclusion, our study reveals a high degree of plasticity in the medaka Lh cell population, resulting from a combination of recruitment and cell proliferation.
A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila
Authors: Wang Zhenghan , Tacchelly-Benites Ofelia , Noble Geoffrey P , Johnson Megan K , Gagné Jean-Philippe , Poirier Guy G , Ahmed Yashi
Published: December 2018

Aberrant activation of the Wnt signal transduction pathway triggers the development of colorectal cancer. The ADP-ribose polymerase Tankyrase (TNKS) mediates proteolysis of Axin—a negative regulator of Wnt signaling—and provides a promising therapeutic target for Wnt-driven diseases. Proteolysis of TNKS substrates is mediated through their ubiquitination by the poly-ADP-ribose (pADPr)-dependent RING-domain E3 ubiquitin ligase RNF146/Iduna. Like TNKS, RNF146 promotes Axin proteolysis and Wnt pathway activation in some cultured cell lines, but in contrast with TNKS, RNF146 is dispensable for Axin degradation in colorectal carcinoma cells. Thus, the contexts in which RNF146 is essential for TNKS-mediated Axin destabilization and Wnt signaling remain uncertain. Herein, we tested the requirement for RNF146 in TNKS-mediated Axin proteolysis and Wnt pathway activation in a range of in vivo settings. Using null mutants in Drosophila, we provide genetic and biochemical evidence that Rnf146 and Tnks function in the same proteolysis pathway in vivo. Furthermore, like Tnks, Drosophila Rnf146 promotes Wingless signaling in multiple developmental contexts by buffering Axin levels to ensure they remain below the threshold at which Wingless signaling is inhibited. However, in contrast with Tnks, Rnf146 is dispensable for Wingless target gene activation and the Wingless-dependent control of intestinal stem cell proliferation in the adult midgut during homeostasis. Together, these findings demonstrate that the requirement for Rnf146 in Tnks-mediated Axin proteolysis and Wingless pathway activation is dependent on physiological context, and suggest that, in some cell types, functionally redundant pADPr-dependent E3 ligases or other compensatory mechanisms promote the Tnks-dependent proteolysis of Axin in both mammalian and Drosophila cells.
Two Antagonistic Hippo Signaling Circuits Set the Division Plane at the Medial Position in the CiliateTetrahymena
Authors: Jiang Yu-Yang , Maier Wolfgang , Baumeister Ralf , Joachimiak Ewa , Ruan Zheng , Kannan Natarajan , Clarke Diamond , Louka Panagiota , Guha Mayukh , Frankel Joseph , Gaertig Jacek
Published: December 2018

Ciliates divide by tandem duplication, a developmental process that remodels the parental cell into two daughters aligned head-to-tail. Here, Jiang et al. investigate the elo1-1 mutation in Tetrahymena that causes the division plan to form too close....

In a single cell, ciliates maintain a complex pattern of cortical organelles that are arranged along the anteroposterior and circumferential axes. The underlying molecular mechanisms of intracellular pattern formation in ciliates are largely unknown. Ciliates divide by tandem duplication, a process that remodels the parental cell into two daughters aligned head-to-tail. In the elo1-1 mutant of Tetrahymena thermophila, the segmentation boundary/division plane forms too close to the posterior end of the parental cell, producing a large anterior and a small posterior daughter cell, respectively. We show that ELO1 encodes a Lats/NDR kinase that marks the posterior segment of the cell cortex, where the division plane does not form in the wild-type. Elo1 acts independently of CdaI, a Hippo/Mst kinase that marks the anterior half of the parental cell, and whose loss shifts the division plane anteriorly. We propose that, in Tetrahymena, two antagonistic Hippo circuits focus the segmentation boundary/division plane at the equatorial position, by excluding divisional morphogenesis from the cortical areas that are too close to cell ends.
Transplantation of Cardiac Mesenchymal Progenitor Cell Sheets for Myocardial Vascularization after an Infarction (Experimental Study)
Authors: Dergilev Konstantin V. , Tsokolaeva Zoya I. , Ryzhkov Ivan A. , Parfenova Elena V.
Published: December 2018

Purpose. To develop a method of producing tissue-engineered constructs (TECs) on the basis of resident mesenchymal progenitor cells (MPC) of the human heart and to assess the effect of TECs transplantation on regenerative processes in the heart using a model of myocardial infarction in rats.Materials and methods. Human resident MPCs were isolated from the right atrial auricle of CAD patients. A similar protocol was used to obtain MPCs from Wistar rats. The MPC immunophenotype was determined by cytofluorometry. Corresponding TECs were obtained on the basis of MPC sheets of human and rats' hearts. Myocardial infarction in rats was induced by ligation of the anterior descending coronary artery followed by TEC transplantation. Euthanasia was performed 30 days after the transplantation. Histological examination of the implant and vascularization cells, morphometric analysis, tracking of the MPC differentiation ability, determination of the content of growth factors by solid-phase ELISA were carried out. Statistical evaluation of the significance of differences was performed using the Statistica 8.0 software package.Results. The analysis of the obtained cell constructs showed that they consisted of several layers of cells interacting with each other by means of connexin 43 and were characterized by good cell viability as a part TECs. The number of vessels in the peri-infarction area under the transplant from the MPC was significantly higher than that in the reference group with signs of differentiation of cardiac MPCs transplanted into endothelial vascular cells.The increased vascularization was combined with an increase in the area of viable myocardial sites and a decrease in LV cavity dilation. Analysis of the cardiac MPC secretion products showed that they produce the most important growth factors and cytokines that regulate angiogenesis and migration of stem cells.Conclusion. The strategy of using epicardial TEC transplantation based on MPC sheets seems to be a rational approach for effective delivery of viable stem/progenitor cells to the damaged myocardium. The use of TEC helps to reduce or temporarily eliminate the effect of factors that contribute to progressive heart dysfunction by local paracrine exposure and activation of the revascularization processes in the affected zone.
Urokinase-Type Plasminogen Activator System in Norm and in Life-Threatening Processes (Review)
Authors: Kugaevskaya Elena V. , Gureeva Tatiana A. , Timoshenko Olga S. , Solovyeva Nina I.
Published: December 2018

The multifunctional urokinase-type plasminogen activator system (uPA-system) includes serine proteinase — uPA or urokinase, its receptor (uPAR) and two inhibitors (PAI-1 and PAI-2). The review discusses the structural features and involvement of the system components in the development of life-threatening processes including carcinogenesis, inflammation, neurogenesis and fibrinolysis, in regulation of which the destruction of extracellular matrix (ECM), cell mobility and signaling inside and outside the cell play a decisive role. uPA triggers the processes by activating the plasminogen and its convertion into plasmin involved in the activation of matrix metalloproteinases (MMPs) in addition to the regulation of fibrinolysis. MMPs can hydrolyze all the major ECM components and therefore play a key role in invasion, metastasis, and cell mobility. MMPs activates a cassette of biologically active regulatory molecules and release them from ECM. uPAR, PAI-1 and PAI-2 are responsible for regulation of the uPA activity. In addition, being a signaling receptor, uPAR along with MMPs lead to the stimulation of a number of signaling pathways that are associated with the regulation of proliferation, apoptosis, adhesion, growth and migration of cells contributing to tumor progression, inflammation, chemotaxis, and angiogenesis. Effective participation of the uPA system components in ECM destruction and regulation of intracellular and extracellular signaling pathways demonstrates that the system significantly contributes to the regulation of various physiological and pathological processes.