bluuebunny/crossref_metadata_2025 huggingface dataset:
A Distribution Static Compensator Using a CFNN-AMF Controller for Power Quality Improvement and DC-Link Voltage Regulation
Authors: Tan Kuang-Hsiung , Lin Faa-Jeng , Tsai Chao-Yang , Chang Yung-Ruei
Published: August 2018

A distribution static compensator (DSTATCOM) is proposed in this study to improve the power quality, which includes the total harmonic distortion (THD) of the grid current and power factor (PF), of a mini grid with nonlinear and linear inductive loads. Moreover, the DC-link voltage regulation control of the DSTATCOM is essential especially under load variation conditions. Therefore, to improve the power quality and keep the DC-link voltage of the DSTATCOM constant under the variation of nonlinear and linear loads effectively, the traditional proportional-integral (PI) controller is substituted with a new online trained compensatory fuzzy neural network with an asymmetric membership function (CFNN-AMF) controller. In the proposed CFNN-AMF, the compensatory parameter to integrate pessimistic and optimistic operations of fuzzy systems is embedded in the CFNN. Furthermore, the dimensions of the Gaussian membership functions are directly extended to AMFs for the optimization of the fuzzy rules and the upgrade of learning ability of the networks. In addition, the network structure and online learning algorithm of the proposed CFNN-AMF are introduced in detail. Finally, the effectiveness and feasibility of the DSTATCOM using the proposed CFNN-AMF controller to improve the power quality and maintain the constant DC-link voltage under the change of nonlinear and linear inductive loads have been demonstrated by some experimental results.
Partial Discharge Analysis in High-Frequency Transformer Based on High-Frequency Current Transducer
Authors: Jiang Jun , Zhao Mingxin , Zhang Chaohai , Chen Min , Liu Haojun , Albarracín Ricardo
Published: August 2018

High-frequency transformers are the core components of power electronic transformers (PET), whose insulation is deeply threatened by high voltage (HV) and high frequency (HF). The partial discharge (PD) test is an effective method to assess an electrical insulation system. A PD measurement platform applying different frequencies was set up in this manuscript. PD signals were acquired with a high-frequency current transducer (HFCT). For improving the signal-to-noise (SNR) ratio of PD pulses, empirical mode decomposition (EMD) was used to increase the SNR by 4 dB. PD characteristic parameters such as partial discharge inception voltage (PDIV) and PD phase, number, and magnitude were all analyzed as frequency dependent. High frequency led to high PDIV and a smaller discharge phase region. PD number and magnitude were first up and then down as the frequency increased. As a result, a suitable frequency for evaluating the insulation of high-frequency transformers is proposed at 8 kHz according to this work.
State of the Art on the Use of Trees as Supports and Anchors in Forest Operations
Authors: Marchi Luca , Grigolato Stefano , Mologni Omar , Scotta Roberto , Cavalli Raffaele , Montecchio Lucio
Published: August 2018

Tree stability assessment is fundamental to preserve the safety of both people and goods. This topic attributes high relevance to cable-supported harvesting where trees and stumps are used as supporting and anchoring elements. In this case, the applied external loads are characterized by higher magnitude and dynamic amplification effects than the typical forces acting on trees (e.g., those derived from meteorological events). Consequently, due to the higher forces involved on cable-supported harvesting on relatively young trees used as supports and anchors, the risk of uprooting and stem failures is real. Numerous studies have been conducted on tree stability and the impact of the external loads has been positively linked to the consequent tree failures, in terms of root-plate overturning and stem breakages, or parasite-mediated wood decay involving the root system, thus giving a better understanding of how different trees species deal with such occurrences. This review aims to synthetize and examine the main aspects covered by research works available in literature that, directly or indirectly, might be helpful in clarifying the behavior of standing trees or tree stumps used as supports and anchors in cable-supported forest operations. Lastly, areas that lack research in this particular topic as well as consequent operating suggestions are highlighted in the conclusions.
Orchestrating Forest Policy in Italy: Mission Impossible?
Authors: Secco Laura , Paletto Alessandro , Romano Raoul , Masiero Mauro , Pettenella Davide , Carbone Francesco , De Meo Isabella
Published: August 2018

In the Italian political and economic agenda the forest sector occupies a marginal role. The forest sector in Italy is characterized by a high institutional fragmentation and centralized decision-making processes dominated by Public Forest Administrations. Public participation in forest policy processes has been implemented since the 1990s at national, regional and local levels in several cases. However, today no significant changes have been observed in the overall governance of the forest sector and stakeholders’ involvement in Italian forest policy decision-making is still rather limited. The aims of this paper are to describe the state of forest-related participatory processes in Italy at various levels (national, regional and local) and identify which factors and actors hinder or support the establishment and implementation of participatory forest-related processes in the country. The forest-related participatory processes are analyzed adopting a qualitative-based approach and interpreting interactive, complex and non-linear participatory processes through the lens of panarchy theory.
Encapsulation of Droplets Using Cusp Formation behind a Drop Rising in a Non-Newtonian Fluid
Authors: Poryles Raphaël , Zenit Roberto
Published: August 2018

The rising of a Newtonian oil drop in a non-Newtonian viscous solution is studied experimentally. In this case, the shape of the ascending drop is strongly affected by the viscoelastic and shear-thinning properties of the surrounding liquid. We found that the so-called velocity discontinuity phenomena is observed for drops larger than a certain critical size. Beyond the critical velocity, the formation of a long tail is observed, from which small droplets are continuously emitted. We determined that the fragmentation of the tail results mainly from the effect of capillary effects. We explore the idea of using this configuration as a new encapsulation technique, where the size and frequency of droplets are directly related to the volume of the main rising drop, for the particular pair of fluids used. These experimental results could lead to other investigations, which could help to predict the droplet formation process by tuning the two fluids’ properties, and adjusting only the volume of the main drop.
Nutritional Characterization of Prosopis laevigata Legume Tree (Mesquite) Seed Flour and the Effect of Extrusion Cooking on its Bioactive Components
Authors: Díaz-Batalla Luis , Hernández-Uribe Juan P. , Gutiérrez-Dorado Roberto , Téllez-Jurado Alejandro , Castro-Rosas Javier , Pérez-Cadena Rogelio , Gómez-Aldapa Carlos A.
Published: August 2018

Mesquite (Prosopis laevigata) is a legume tree widely distributed in Aridoamerica. The mature fruit of this legume is a pod, which is currently underutilized and has high nutritional potential. In the present work, mesquite seed flour is described in terms of its nutritional value, as well as the effect of extrusion cooking on its bioactive components. Mesquite seed flour is rich in fiber (7.73 g/100 g) and protein (36.51 g/100 g), with valine as the only limiting amino acid. Total phenolic compound contents in raw and extruded seed flour were 6.68 and 6.46 mg of gallic acid equivalents/g (mg GAE/g), respectively. 2-2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity values in raw and extruded seed flour were 9.11 and 9.32 mg of ascorbic acid equivalent/g (mg AAE/g), respectively. The absorbance at 290 nm, as an indicator of generation of Maillard reaction product (MRP), was the same for raw and extruded samples. Apigenin was the only flavonoid found in mesquite seed flour (41.6 mg/kg) and was stable in the extrusion process. The water absorption index (WAI) and water solubility index (WSI) were changed significantly during extrusion. The expansion of mesquite seed flour extrudates was null due to the high protein and fiber content in the sample. Extrusion cooking of mesquite seed flour is a useful form of technology for the industrialization of this underutilized and nutritionally valuable legume.
Introduction to a New Open Access Journal by MDPI: Future Physics
Authors: Sarkisyan-Grinbaum Edward
Published: August 2018

I am proud to announce the launch of a new MDPI journal, Future Physics, for which I am honored to serve as Editor-in-Chief as this topic is currently of high interest and it promises to be a very interesting publication forum. [...]
Structural and Evolutionary Insights within the Polysaccharide Deacetylase Gene Family of Bacillus anthracis and Bacillus cereus
Authors: Andreou Athena , Giastas Petros , Christoforides Elias , Eliopoulos Elias E.
Published: August 2018

Functional and folding constraints impose interdependence between interacting sites along the protein chain that are envisaged through protein sequence evolution. Studying the influence of structure in phylogenetic models requires detailed and reliable structural models. Polysaccharide deacetylases (PDAs), members of the carbohydrate esterase family 4, perform mainly metal-dependent deacetylation of O- or N-acetylated polysaccharides such as peptidoglycan, chitin and acetylxylan through a conserved catalytic core termed the NodB homology domain. Genomes of Bacillus anthracis and its relative Bacillus cereus contain multiple genes of putative or known PDAs. A comparison of the functional domains of the recently determined PDAs from B. anthracis and B. cereus and multiple amino acid and nucleotide sequence alignments and phylogenetic analysis performed on these closely related species showed that there were distinct differences in binding site formation, despite the high conservation on the protein sequence, the folding level and the active site assembly. This may indicate that, subject to biochemical verification, the binding site-forming sequence fragments are under functionally driven evolutionary pressure to accommodate and recognize distinct polysaccharide residues according to cell location, use, or environment. Finally, we discuss the suggestion of the paralogous nature of at least two genes of B. anthracis, ba0330 and ba0331, via specific differences in gene sequence, protein structure, selection pressure and available localization patterns. This study may contribute to understanding the mechanisms under which sequences evolve in their structures and how evolutionary processes enable structural variations.
A New Occurrence of Terrestrial Native Iron in the Earth’s Surface: The Ilia Thermogenic Travertine Case, Northwestern Euboea, Greece
Authors: Kanellopoulos Christos , Valsami-Jones Eugenia , Voudouris Panagiotis , Stouraiti Christina , Moritz Robert , Mavrogonatos Constantinos , Mitropoulos Panagiotis
Published: August 2018

Native iron has been identified in an active thermogenic travertine deposit, located at Ilia area (Euboea Island, Greece). The deposit is forming around a hot spring, which is part of a large active metallogenetic hydrothermal system depositing ore-bearing travertines. The native iron occurs in two shapes: nodules with diameter 0.4 and 0.45 cm, and angular grains with length up to tens of μm. The travertine laminae around the spherical/ovoid nodules grow smoothly, and the angular grains are trapped inside the pores of the travertine. Their mineral-chemistry is ultra-pure, containing, other than Fe, only Mn (0.34–0.38 wt.%) and Ni (≤0.05 wt.%). After evaluating all the possible environments where native iron has been reported up until today and taking under consideration all the available data concerning the study area, we propose two possible scenarios: (i) Ilia’s native iron has a magmatic/hydrothermal origin i.e., it is a deep product near the magmatic chamber or a peripheral cooling igneous body that was transferred during the early stages of the geothermal field evolution, from high temperature, reduced gas-rich fluids and deposited along with other metals in permeable structural zones, at shallow levels. Later on, it was remobilized and mechanically transferred and precipitated at the Ilia’s thermogenic travertine by the active lower temperatures geothermal fluids; (ii) the native iron at Ilia is remobilized from deep seated ophiolitic rocks, originated initially from reduced fluids during serpentinization processes; however, its mechanical transport seems less probable. The native iron mineral-chemistry, morphology and the presence of the other mineral phases in the same thermogenic travertine support both hypotheses.
Illness Representation and Self-Care Ability in Older Adults with Chronic Disease
Authors: Rivera Eleanor , Corte Colleen , Steffen Alana , DeVon Holli A. , Collins Eileen G. , McCabe Pamela J.
Published: August 2018

Chronic illness affects >50% of adults in the United States and accounts for >80% of healthcare spending. The purpose of this study was to determine whether beliefs about one’s chronic disease (illness representation) are associated with self-care activation, emergency department (ED) visits, or hospitalizations. Using a cross-sectional design, we recruited older adults with heart failure, chronic obstructive pulmonary disease (COPD), and chronic kidney disease. The Revised Illness Perception Questionnaire (IPQ-R) measured perceptions about disease. The Patient Activation Measure measured self-care activation. ED visits and hospitalizations were measured by self-report. IPQ-R scores were analyzed using latent profile analysis to identify subgroups. Participants included 187 adults (mean age 65 years, 54% female, 74% Black). We found three subgroups (stable, overwhelmed, and confident). Groups did not differ demographically or by disease. The stable group (few consequences, non-fluctuating pattern) had the fewest hospitalizations. The overwhelmed group (many consequences, fluctuating pattern, high negative emotion) had high hospitalizations and low self-care ability. The confident group (high disease control, well-understood) had the highest self-care ability, but also high hospitalizations. ED visits did not differ by group. We found three subgroups that differ in their illness representation and health outcomes. Findings suggest that assessing patients’ illness representations may have important implications for subgroup-specific interventions.
Allaying Terror: Domesticating Vietnamese Refugee Artisans as Subjects of American Diplomacy
Authors: Way Jennifer
Published: August 2018

A photograph of a basketmaker and photographs of other refugee artisans published in the August 1956 issue of Interiors magazine iterated some common themes of refugee narratives during a decade of significant migration that saw the United Nations sponsor World Refugee Year in 1959. Of particular interest are the ways the publication of the basketmaker photograph helped to demonstrate how Vietnamese refugee artisans suited the needs of an American State Department-led aid project directed by the industrial designer Russel Wright in South Vietnam from 1955–61. The project aimed to export Vietnamese craft to the American middle class as a way to bring South Vietnam into the Free World during the Cold War. This essay explores how the photograph served the American State Department agenda by characterizing its subject in terms of pathos and need. To this point, it helped to allay American anxieties about supporting refugee artisans by depoliticizing the “refugee problem” and resolving it. In this case, refugee photography expressed how the interests of American diplomacy were linking to the American middle class as a demographic becoming synonymous with consumption and whiteness.
Tetanus Vaccination and Extra-Immunization among Adult Populations: Eight-Year Follow Up Cohort Study of 771,443 Adults in Taiwan, 2006–2013
Authors: Liu Shih-Wei , Huang Liang-Chung , Chung Wu-Fu , Wu Jauching , Chen Li-Fu , Chen Yu-Chun
Published: August 2018

Under-and extra-immunization of tetanus boosters are important issues to consider in reducing the burden of vaccine-preventable disease in adults. The present study aimed to analyze the trend of vaccination coverage (VC) and risk factors associated with extra-immunization of tetanus during an 8-year period using a national-scale cohort database. Taiwan’s one-million representative research database, the Longitudinal Health Insurance Database (LHID2005) was used. A total of 771,443 adults aged between 20 and 79 years were enrolled and followed from 1 January 2006 to 31 December 2013. VC at the beginning was as low as 35.1%, declining gradually and dropping to 33.9% at the end of follow-up. While a total of 303,480 tetanus boosters were used during the study period, more than half (55.5%) of these boosters were considered as extra-immunized. Both individual characteristics and visit characteristics were strongly associated with extra-immunization. Males, young and older adults, and those with a higher number of comorbidities were more likely to receive extra-immunization boosters, especially when they had more severe symptoms, visited an emergency room, or visited a hospital with lower accreditation levels located in a less urbanized area. This information could enhance implementation of evidence-based programs for tetanus boosters.
Effects of the Conceptual Model of Health Literacy as a Risk: A Randomised Controlled Trial in a Clinical Dental Context
Authors: Stein Linda , Bergdahl Maud , Pettersen Kjell Sverre , Bergdahl Jan
Published: August 2018

Numerous conceptual models of health literacy have been proposed in the literature, but very few have been empirically validated in clinical contexts. The aim of this study was to test the effects of the conceptual model of health literacy as a risk in a clinical dental context. A convenience sample of 133 Norwegian-speaking adults was recruited. Participants were randomly allocated to an intervention group (n = 64, 54% women, mean age = 50 years) and a control group (n = 69, 49% women, mean age = 46 years). Clinical measurements were conducted pre-intervention and six months post-intervention. In the intervention group, communication regarding patients’ oral health was tailored to their health literacy levels using recommended communication techniques, whereas the control group received brief information not tailored to health literacy levels. The ANCOVA showed significant between-group effects, finding reduced post-intervention mean gingival (p < 0.000) and mean plaque (p < 0.000) indices in the intervention group when controlling for baseline index scores. The adjusted Cohen’s d indicated large effect sizes between the intervention group and the control group for both the mean gingival index (−0.98) and the mean plaque index (−1.33). In conclusion, the conceptual model of health literacy as a risk had a large effect on important clinical outcomes, such as gingival status and oral hygiene. The model may be regarded as a suitable supplement to patient education in populations.
Identifying Modes of Driving Railway Trains from GPS Trajectory Data: An Ensemble Classifier-Based Approach
Authors: Zheng Han , Cui Zanyang , Zhang Xingchen
Published: August 2018

Recognizing Modes of Driving Railway Trains (MDRT) can help to solve railway freight transportation problems in driver behavior research, auto-driving system design and capacity utilization optimization. Previous studies have focused on analyses and applications of MDRT, but there is currently no approach to automatically and effectively identify MDRT in the context of big data. In this study, we propose an integrated approach including data preprocessing, feature extraction, classifiers modeling, training and parameter tuning, and model evaluation to infer MDRT using GPS data. The highlights of this study are as follows: First, we propose methods for extracting Driving Segmented Standard Deviation Features (DSSDF) combined with classical features for the purpose of improving identification performances. Second, we find the most suitable classifier for identifying MDRT based on a comparison of performances of K-Nearest Neighbor, Support Vector Machines, AdaBoost, Random Forest, Gradient Boosting Decision Tree, and XGBoost. From the real-data experiment, we conclude that: (i) The ensemble classifier XGBoost produces the best performance with an accuracy of 92.70%; (ii) The group of DSSDF plays an important role in identifying MDRT with an accuracy improvement of 11.2% (using XGBoost). The proposed approach has been applied in capacity utilization optimization and new driver training for the Baoshen Railway.
Software Systems Approach to Multi-Scale GIS-BIM Utility Infrastructure Network Integration and Resource Flow Simulation
Authors: Gilbert Thomas , Barr Stuart , James Philip , Morley Jeremy , Ji Qingyuan
Published: August 2018

There is an increasing impetus for the use of digital city models and sensor network data to understand the current demand for utility resources and inform future infrastructure service planning across a range of spatial scales. Achieving this requires the ability to represent a city as a complex system of connected and interdependent components in which the topology of the electricity, water, gas, and heat demand-supply networks are modelled in an integrated manner. However, integrated modelling of these networks is hampered by the disparity between the predominant data formats and modelling processes used in the Geospatial Information Science (GIS) and Building Information Modelling (BIM) domains. This paper presents a software systems approach to scale-free, multi-format, integrated modelling of evolving cross-domain utility infrastructure network topologies, and the analysis of the spatiotemporal dynamics of their resource flows. The system uses a graph database to integrate the topology of utility network components represented in the CityGML UtilityNetwork Application Domain Extension (ADE), Industry Foundation Classes (IFC) and JavaScript Object Notation (JSON) real-time streaming messages. A message broker is used to disseminate the changing state of the integrated topology and the dynamic resource flows derived from the streaming data. The capability of the developed system is demonstrated via a case study in which internal building and local electricity distribution feeder networks are integrated, and a real-time building management sensor data stream is used to simulate and visualise the spatiotemporal dynamics of electricity flows using a dynamic web-based visualisation.
Protease-Activated Receptor 1 as Therapeutic Target in Breast, Lung, and Ovarian Cancer: Pepducin Approach
Authors: Covic Lidija , Kuliopulos Athan
Published: August 2018

The G-protein coupled receptors (GPCRs) belong to a large family of diverse receptors that are well recognized as pharmacological targets. However, very few of these receptors have been pursued as oncology drug targets. The Protease-activated receptor 1 (PAR1), which is a G-protein coupled receptor, has been shown to act as an oncogene and is an emerging anti-cancer drug target. In this paper, we provide an overview of PAR1’s biased signaling role in metastatic cancers of the breast, lungs, and ovaries and describe the development of PAR1 inhibitors that are currently in clinical use to treat acute coronary syndromes. PAR1 inhibitor PZ-128 is in a Phase II clinical trial and is being developed to prevent ischemic and thrombotic complication of patients undergoing cardiac catheterization. PZ-128 belongs to a new class of cell-penetrating, membrane-tethered peptides named pepducins that are based on the intracellular loops of receptors targeting the receptor G-protein interface. Application of PZ-128 as an anti-metastatic and anti-angiogenic therapeutic agent in breast, lung, and ovarian cancer is being reviewed.
RNA-seq Analysis Reveals Gene Expression Profiling of Female Fertile and Sterile Ovules of Pinus Tabulaeformis Carr. during Free Nuclear Mitosis of the Female Gametophyte
Authors: Yao Yang , Han Rui , Gong Zaixin , Zheng Caixia , Zhao Yuanyuan
Published: August 2018

The development of the female gametophyte (FG) is one of the key processes of life cycle alteration between the haploid gametophyte and the diploid sporophytes in plants and it is required for successful seed development after fertilization. It is well demonstrated that free nuclear mitosis (FNM) of FG is crucial for the development of the ovule. However, studies of the molecular mechanism of ovule and FG development focused mainly on angiosperms, such as Arabidopsis thaliana and further investigation of gymnosperms remains to be completed. Here, Illumina sequencing of six transcriptomic libraries obtained from developing and abortive ovules at different stages during free nuclear mitosis of magagametophyte (FNMM) was used to acquire transcriptome data and gene expression profiles of Pinus tabulaeformis. Six cDNA libraries generated a total of 71.0 million high-quality clean reads that aligned with 63,449 unigenes and the comparison between developing and abortive ovules identified 7174 differentially expressed genes (DEGs). From the functional annotation results, DEGs involved in the cell cycle and phytohormone regulation were highlighted to reveal their biological importance in ovule development. Furthermore, validation of DEGs from the phytohormone signal transduction pathway was performed using quantitative real-time PCR analysis, revealing the dynamics of transcriptional networks and potential key components in the regulation of FG development in P. tabulaeformis were identified. These findings provide new insights into the regulatory mechanisms of ovule development in woody gymnosperms.
Modeling Analytical Streams for Social Business Intelligence
Authors: Lanza-Cruz Indira , Berlanga Rafael , Aramburu María José
Published: August 2018

Social Business Intelligence (SBI) enables companies to capture strategic information from public social networks. Contrary to traditional Business Intelligence (BI), SBI has to face the high dynamicity of both the social network’s contents and the company’s analytical requests, as well as the enormous amount of noisy data. Effective exploitation of these continuous sources of data requires efficient processing of the streamed data to be semantically shaped into insightful facts. In this paper, we propose a multidimensional formalism to represent and evaluate social indicators directly from fact streams derived in turn from social network data. This formalism relies on two main aspects: the semantic representation of facts via Linked Open Data and the support of OLAP-like multidimensional analysis models. Contrary to traditional BI formalisms, we start the process by modeling the required social indicators according to the strategic goals of the company. From these specifications, all the required fact streams are modeled and deployed to trace the indicators. The main advantages of this approach are the easy definition of on-demand social indicators, and the treatment of changing dimensions and metrics through streamed facts. We demonstrate its usefulness by introducing a real scenario user case in the automotive sector.
The Rolling of Food by Dung Beetles Affects the Oviposition of Competing Flies
Authors: Ix-Balam Manuel A. , A. Oliveira Maria G. , Louzada Júlio , McNeil Jeremy N. , Lima Eraldo
Published: August 2018

Flies are the main competitors of dung beetles for oviposition sites and rolling dung beetles relocate their food to reduce interspecific competition. Furthermore, dung beetles deposit chemical substances on the food ball that may repel fly larvae and certain predators. In the present study, using Deltochilum furcatum, a dung beetle that does not exhibit parental care and the blow-fly, Lucilia cuprina, we tested the hypothesis that pygidial secretions deposited on the food ball could also make it less attractive as an oviposition site for flies. Food balls rolled by either D. furcatum males or females received significantly fewer eggs that balls that had not been rolled by beetles. Also, flies laid significantly fewer eggs on food balls treated with secretions collected from male pygidial glands. Reduced fly oviposition may be a direct effect of compounds the beetles deposited, acting as an allomone, and/or an indirect negative effect on the microbial community that stimulates fly oviposition. A model of the reproductive biology of this species is proposed.
Defoliation of Soybean Expressing Cry1Ac by Lepidopteran Pests
Authors: Murúa María G. , Vera Martín A. , Herrero María I. , Fogliata Sofia V. , Michel Andrew
Published: August 2018

Lepidoptera, stink bugs, and weevils are important pests in soybean. For lepidopteran control, insecticides and seed treatments are used. As an alternative, Bt soybean was developed to control primary pests of Lepidoptera such as Rachiplusia nu (Guenée) (Noctuidae), Chrysodeixisincludens (Walker) (Noctuidae), Anticarsia gemmatalis Hübner (Erebidae), Helicoverpa gelotopoeon (Dyar) (Noctuidae), and Crocidosema aporema (Walsingham) (Tortricidae). However, the use of transgenic plants, and the resulting reduction of insecticide against target pests, may allow other pest species to become more prevalent in agricultural environments. Soybean expressing Cry1Ac against different lepidopteran nontarget and target insect pests was evaluated, and its performance was compared with non-Bt soybean with seed treatment. The treatments were Bt soybean, non-Bt soybean with seed treatment (Fortenza® diamide insecticide, Syngenta, Buenos Aires, Argentina), and non-Bt soybean without seed treatment. Larvae of H. gelotopoeon, Spodoptera albula (Walker) (Noctuidae), Spodoptera cosmiodes (Walker) (Noctuidae), Spodoptera eridania (Stoll) (Noctuidae), and Spodoptera frugiperda (J. E. Smith) (Lep.: Noctuidae) were used. The plants of each treatment were infested with larvae of each species, and the percentage of leaf damage produced by each species was recorded. The results showed that Bt soybean provided control of H. gelotopoeon and had a suppressive effect on S. frugiperda and S. albula. However, S. eridania and S. cosmiodes were not susceptible to the Cry1Ac protein in MON 87701 × MON 89788 soybean when evaluated by greenhouse infestation. Considering the performance of each species using non-Bt soybean without seed treatment, S. eridania would represent a potential risk in soybean crops.
Syphilis Trends in the Central Savannah River Area (CSRA) of Georgia and South Carolina, USA
Authors: Stone Rebecca , Chung Yunmi , Ansa Benjamin
Published: August 2018

There has been an alarming resurgence of early syphilis since 2000, especially in the southeast region, which has one of the highest rates of primary and secondary syphilis in the United States of America (USA). Although the Central Savannah River Area (CSRA) is the second most populous area in Georgia with a large presence of health care facilities, its counties have one of the lowest overall rankings in health outcomes. This study examined the syphilis rates and trends in the CSRA. Data from the Centers for Disease Control and Prevention (CDC) National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention’s AtlasPlus was used. Cases of primary and secondary syphilis diagnosed during 2010–2015 were analyzed to describe reported syphilis among CSRA residents. In the CSRA, between 2010 and 2015, the incidence rate of primary and secondary syphilis increased from 5.9 to 9.4 cases per 100,000 population. The lowest rate of syphilis was observed in 2011 (2.7 cases per 100,000) and the highest rate in 2015. In 2015, the highest syphilis rates were observed among males (15.9 per 100,000), non-Hispanic blacks (16.9 per 100,000), and persons between the ages 20–24 years (34.5 per 100,000). The relevance of preventive measures has been widely communicated, yet it is clear that risk-taking sexual behavior is on the rise. Greater effort is warranted to reduce risky behaviors that promote the transmission of syphilis, including areas outside of major metropolitan areas.
Brief Review: Ergospirometry in Patients with Obstructive Sleep Apnea Syndrome
Authors: Stavrou Vasileios , Bardaka Fotini , Karetsi Eleni , Daniil Zoe , Gourgoulianis Konstantinos
Published: August 2018

This brief review summarizes the available literature on the intersection of obstructive sleep apnea syndrome (OSAS) and ergospirometry. Ergospirometry provides an assessment of integrative exercise responses involving pulmonary, cardiovascular, neuropsychological, and skeletal muscle systems, which are not adequately reflected through the measurement of individual organ system functions. Sleep disorders, including OSAS, often exacerbate problems in the operation of the autonomic nervous system, heart function, lung mechanics, anxiety, and muscle metabolism. Patients with OSAS have low aerobic capacity due to dysfunction of these systems, which often affect quality of sleep. Further research is necessary to elucidate the precise mechanisms through which ergospirometry can be useful in the assessment and early identification of patients with OSAS.
Prognostic Relevance of Circulating 25OHD Fractions for Early Recovery and Survival in Patients with Hip Fracture
Authors: Toldy Erzsébet , Salamon Antal , Kálmán Bernadette , Ágota Katalin , Horváth Dániel , Lőcsei Zoltán
Published: August 2018

The relation between vitamin-D (VD) status and healing after hip fracture had not been sufficiently addressed. Currently serum total 25-hydroxy-VD (t-25OHD) is the most widely used indicator of VD status. It is unclear whether free or bioavailable VD are better markers of 25OHD availability for tissues. Validity of overall cut-off values of t-25OHD is limited. Objectives: (1) Assess serum levels of circulating forms of 25OHD in patients with hip fracture (PwHF: N = 199) compared to active controls without history of fracture (N = 102); (2) determine relationship between 25OHD fractions and functional performance after surgery (FPAS) and survival. The t-25OHD; VD binding protein and albumin levels were measured. Comorbidities; lifestyle; FPAS and survival were recorded at seven months. VD deficiency occurred more frequently in PwHF than in controls (72% vs. 38%). Patients with better FPAS showed higher 25OHD in all fractions than with poor FPAS. Controlled by lifestyle; 25OHD levels were independent predictive factors (p < 0.001). Good FPAS values forecasted longer survival (OR: 6.5CI:3.2–13.3; p < 0.0001). All 25OHD forms showed a tendency to predict survival. Mortality rate decreased to 8% in individuals with t-25OHD levels of >22.6–39.5 nmol/L and increased to 14% with >40 nmol/L. These observations highlight the importance of serum 25OHD assessment and moderate VD substitution for healing and survival.
3-(3,5-Difluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde
Authors: Kumar Naveen , Sreenivasa Swamy , Kumar Vasantha , Mohan Nadigar
Published: August 2018

Vilsmeier–Haack reaction of (E)-1-[1-(3,5-difluorophenyl)ethylidene]-2-phenylhydrazine (1) using dimethyl formamide in excess of phosphorus oxychloride by conventional method, resulted in the synthesis of the title compound 3-(3,5-difluorophenyl)-1-phenyl-1H-pyrazole-4- carbaldehyde (2) in good yield and high purity. Structure characterization of the title compound was done by IR, 1H-NMR, 13C-NMR and HRMS spectral analysis.
Coarse-Grained Simulations Using a Multipolar Force Field Model
Authors: Chiu Shuo-Feng , Chao Sheng D.
Published: August 2018

This paper presents a coarse-grained molecular simulation for fullerenes based on a multipolar expansion method developed previously. The method is enabled by the construction of transferable united atoms potentials that approximate the full atomistic intermolecular interactions, as obtained from ab initio electronic structure calculations supplemented by empirical force fields and experimental data, or any combination of the above. The resultant series contains controllable moment tensors that allow to estimate the errors, and approaches the all-atom intermolecular potential as the expansion order increases. We can compute the united atoms potentials very efficiently with a few interaction moment tensors, in order to implement a parallel algorithm on molecular interactions. Our simulations describe the mechanism for the condensation of fullerenes, and they produce excellent agreement with benchmark fully atomistic molecular dynamics simulations.
Homogeneous Continuous-Time, Finite-State Hidden Semi-Markov Modeling for Enhancing Empirical Classification System Diagnostics of Industrial Components
Authors: Cannarile Francesco , Compare Michele , Baraldi Piero , Di Maio Francesco , Zio Enrico
Published: August 2018

This work presents a method to improve the diagnostic performance of empirical classification system (ECS), which is used to estimate the degradation state of components based on measured signals. The ECS is embedded in a homogenous continuous-time, finite-state semi-Markov model (HCTFSSMM), which adjusts diagnoses based on the past history of components. The combination gives rise to a homogeneous continuous-time finite-state hidden semi-Markov model (HCTFSHSMM). In an application involving the degradation of bearings in automotive machines, the proposed method is shown to be superior in classification performance compared to the single-stage ECS.
Evaluation of the Sleep-Prolonging Effect of Lagenaria vulgaris and Cucurbita pepo Extracts on Pentobarbital-Induced Sleep and Possible Mechanisms of Action
Authors: Baradaran Rahimi Vafa , Askari Vahid , Tajani Amineh , Hosseini Azar , Rakhshandeh Hassan
Published: August 2018

Introduction: Sleeplessness is the most common sleep disorder. In this study, the hypnotic effect of macerated (HAME) and soxhlet (HASE) extract of Lagenaria vulgaris (fruit and seed) and Cucurbita pepo (fruit) were studied in mice. Methods: Extracts and fractions were administered intra-peritoneally (i.p.) in mice 30 min before the sodium pentobarbital (30 mg/kg, i.p.). Moreover, the influence of flumazenil or naloxone on the hypnotic effects of the extract and its toxic effects were evaluated. Results: The HAME and HASE of C. pepo prolonged the pentobarbital-induced sleep duration at dose of 200 mg/kg. The HAME of L. vulgaris (fruit) at dose of 200 mg/kg increased the sleeping time. The HAME and HASE of L. vulgaris (seed) increased sleep duration at doses of 50 and 100 mg/kg. Besides, flumazenil (2 mg/kg) reversed the effects of both diazepam (P < 0.001 vs. diazepam group), 200 mg/kg of HAME of C. pepo and 50 mg/kg of HAME and HASE of L. vulgaris (seed). All fractions especially ethyl-acetate fraction (EAF) of L. vulgaris (seed) increased the sleep duration. Naloxone reversed the hypnotic effect of HAME and HASE of L. vulgaris (seed). The extracts showed no neurotoxic effects on PC12 and L929 cell lines. Conclusion: The results showed that L. vulgaris (seed and fruit) and C. pepo potentiated pentobarbital hypnosis without toxic influence. The hypnotic effects of L. vulgaris seed was greater than its fruit and C. pepo. The GABA and opioid receptors may play role in the sleep-induction of L. vulgaris seed.
Behavioral, Psychiatric, and Cognitive Adverse Events in Older Persons Treated with Glucocorticoids
Authors: Manzo Ciro , Serra-Mestres Jordi , Castagna Alberto , Isetta Marco
Published: August 2018

Background: Since the introduction of glucocorticoids (GCs) in the physician’s pharmacological arsenal, it has been known that they are a cause of behavioral or psychiatric adverse events (BPAE), as well as of cognitive problems. To the best of our knowledge, the relationship between these adverse events and GCs in older persons has never been evaluated, except through case-reports or series with few cases. In this paper, a review of the literature regarding BPAEs and cognitive disorders in older people treated with CSs is undertaken. Methods: A comprehensive literature search for BPAEs was carried out on the three main bibliographic databases: EMBASE, MEDLINE and PsycINFO (NICE HDAS interface). Emtree terms were: Steroid, steroid therapy, mental disease, mania, delirium, agitation, depression, behavior change, dementia, major cognitive impairment, elderly. The search was restricted to all clinical studies and case reports with focus on the aged (65+ years) published in any language since 1998. Results: Data on the prevalence of the various BPAEs in older patients treated with GCs were very scarse, consisting mainly of case reports and of series with small numbers of patients. It was hence not possible to perform any statistical evaluation of the data (including meta-analysis). Amongst BPAEs, he possibility that delirium can be induced by GCs has been recently been questioned. Co-morbidities and polypharmacy were additional risk factors for BPAEs in older persons. Conclusions: Data on BPAEs in older persons treated with GCs, have several unmet needs that need to be further evaluated with appropriately designed studies.
Factors Affecting Mass Transport Properties of Poly(ε-caprolactone) Membranes for Tissue Engineering Bioreactors
Authors: Diban Nazely , Gómez-Ruiz Beatriz , Lázaro-Díez María , Ramos-Vivas Jose , Ortiz Inmaculada , Urtiaga Ane
Published: August 2018

High porosity and mass transport properties of microfiltration polymeric membranes benefit nutrients supply to cells when used as scaffolds in interstitial perfusion bioreactors for tissue engineering. High nutrients transport is assumed when pore size and porosity of the membrane are in the micrometric range. The present work demonstrates that the study of membrane fouling by proteins present in the culture medium, though not done usually, should be included in the routine testing of new polymer membranes for this intended application. Two poly(ε-caprolactone) microfiltration membranes presenting similar average pore size (approximately 0.7 µm) and porosity (>80%) but different external surface porosity and pore size have been selected as case studies. The present work demonstrates that a membrane with lower surface pore abundance and smaller external pore size (approximately 0.67 µm), combined with adequate hydrodynamics and tangential flow filtration mode is usually more convenient to guarantee high flux of nutrients. On the contrary, having large external pore size (approximately 1.70 µm) and surface porosity would incur important internal protein fouling that could not be prevented with the operation mode and hydrodynamics of the perfusion system. Additionally, the use of glycerol in the drying protocols of the membranes might cause plasticization and a consequent reduction of mass transport properties due to membrane compaction by the pressure exerted to force perfusion. Therefore, preferentially, drying protocols that omit the use of plasticizing agents are recommended.
Long-Term Performance of a Full-Scale Membrane Plant for Landfill Leachate Pretreatment: A Case Study
Authors: Coppini Ester , Palli Laura , Fibbi Donatella , Gori Riccardo
Published: August 2018

This paper presents a case study describing a full-scale membrane bioreactor (MBR) for the pretreatment of landfill leachates. The treatment train includes an aerated equalization tank, a denitrification tank, an oxidation/nitrification tank, and two ultrafiltration units. The plant has worked continuously since 2008 treating landfill leachates at a flux of 2–11 L·h−1·m−2. The old train of membranes worked in these conditions for more than seven years prior to being damaged and replaced. The permeability (K) of the membrane varied between 30 and 80 L·h−1·m−2·bar−1 during the years of operation. In 2010, after two years of operation, the oxidation/nitrification tank was changed to work in alternate cycles of aerated and anoxic conditions, in order to improve the denitrification process. The MBR, working at a mean sludge retention time of 144 days and with mixed liquor suspended solids of 17 g/L, achieved high removal rates of conventional contaminants, with more than 98% for Biochemical Oxygen Demand, 96% for ammonium, and 75% for Chemical Oxygen Demand (COD). From the COD balance, half the COD entering was determined to be biologically oxidized into carbon dioxide, while another 24% remains in the sludge. In order to obtain these results, the company used 5.2 KWh·m−3, while spending 0.79 €·m−3.
Key Intelligent Technology of Steel Strip Production through Process
Authors: Sun Jie , Peng Wen , Ding Jingguo , Li Xu , Zhang Dianhua
Published: August 2018

Because of the complexity of procedure interface and working conditions, the further improvement of steel strip quality and production efficiency is limited. Realizing the optimization of product quality and production process in multi-process, system-level through intelligent key technology is one of the strategic directions in steel strip production. (1) Collaborative intelligent optimization and dynamic scheduling technology for steel manufacturing supply chain oriented to customized production, reducing the cost of raw material purchase and production operations and improving production efficiency and precision service ability; (2) Online monitoring, diagnosis and optimization technology of product quality. Getting through the process information flow of product, the correlation analysis of process quality parameters, the tracing of quality anomalies, the reverse optimization of process parameters and the optimization of process route will be realized; (3) Multi-process coordination optimization and quality control based on CPS architecture. The precise control technology of process quality parameters will be developed; the structure of multi-process coordination optimization system is established and optimization of key quality parameters in the through process will be realized; and (4) Microstructure and mechanical property optimization and surface quality intelligent control technology in the hot strip rolling process. Intelligent prediction of microstructure and mechanical properties, rapid dynamic design and steel grade merging technology will be formed and green process design technology of oxide scale will be developed.
Modification of Porous Aluminum by Cold Rolling for Low-Noise Trailing Edge Applications
Authors: Tychsen Jörn , Lippitz Nicolas , Rösler Joachim
Published: August 2018

Noise reduction of aircrafts during take-off and landing has become an important part of research in aviation. The circulation of air around the airframe is a major source of noise during landing. This includes noise generated at the trailing edge. Open porous materials, such as porous aluminum, are investigated for the reduction of this noise. In this study, cold rolling is used to enhance the structure of porous aluminum in matters of aeroacoustics and mechanical properties. An important parameter characterizing the acoustic behavior is flow resistivity which is measured using the alternating airflow method. The flow resistivity is highly dependent upon the pore structure which is analyzed using three-dimensional computer tomography (CT). Additionally, CT combined with discontinuous tensile testing is used to study the influence of cold rolling on the damage behavior of porous aluminum. Besides the damage behavior, mechanical parameters have been determined to identify reasonable degrees of deformation. A cold rolling technique to produce material with a gradient in porosity is described and experimental porous trailing edges for measurements in an acoustic wind tunnel are shown. The findings of this study show that cold rolling is a promising way to customize porous aluminum for low-noise trailing edge applications.