bluuebunny/crossref_metadata_2025 huggingface dataset:
How pediatric resident’s life has changed during the COVID-19 pandemic
Authors: Votto Martina , De Filippo Maria ,   On behalf of the Pediatric Residents of the University of Pavia, Italy, Rossella Amariti , Beatrice Andrenacci , Antonia Apicella , Francesco Bassanese , Emanuela Bellanca , Giacomo Bonitatibus , Giovanni Bottino , Giulia Casari , Paola Castelli , Anna Cervone , Clemente Andrea Martina , Carmela Crapanzano , Francesco Delle Cave , Giulia Di Vincenzo , Giulia Dobbiani , Myriam Donesana , Francesco Fasolino , Ferrara Ursula Pia , Ivan Fiorito , Claudia Garassino , Chiara Gertosio , Francesca Giffoni , Marco Gregnanin , Carmen Guarracino , Irene Ioimo , Lucia Iozzi , Rosario Ippolito , Enrico Landi , Anna Larocca , Buono Laura , Claudio Lavarello , Leon Joya Anita , Francesca Loiacono , Alessandra Maggio , Magistrali Mariasol , Erika Maglie , Manganelli Nunzia Pia , Alexandre Michev , Alice Moiraghi , Paola Musso , Matteo Naso , Cecilia Novara , Francesca Olivero , Valeria Paganelli , Paola Pagliara , Giulia Raffa , Chiara Raviola , Corrado Regalbuto , Francesca Rivano , Giulia Roberto , Alessandra Rossi , Federico Rossi , Viola Santi , Simona Semeria Mantelli , Cecilia Silvi , Giulia Siri , Eugenia Spreafico , Enrico Tondina , Chiara Trabatti , Daniele Veraldi , Antonio Vergori , Federica Vinci , Eleonora Vitrani , Viola Vittoni , Andreana Zecchini
Published: October 2020

Since the World Health Organization declared Coronavirus Disease 2019 (COVID-19) a global pandemic, a few articles were published on the working experience of pediatric residents, especially from the most exposed countries worldwide. Pediatric residents continue to be essential pillars in managing and treating pediatric diseases and are currently fundamental health care providers for every ill patient, including children and adolescents with COVID-19. Although severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection is changing everyone’s life, this previously unknown disease can represent a training tool and a hard challenge for pediatric residents to improve their skills and take part in an ongoing process of knowledge.
Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers—results from the DELCODE study
Authors: Sannemann Lena , Schild Ann-Katrin , Altenstein Slawek , Bartels Claudia , Brosseron Frederic , Buerger Katharina , Cosma Nicoleta Carmen , Fliessbach Klaus , Freiesleben Silka Dawn , Glanz Wenzel , Heneka Michael T. , Janowitz Daniel , Kilimann Ingo , Kobeleva Xenia , Laske Christoph , Metzger Coraline D. , Munk Matthias H. J. , Perneczky Robert , Peters Oliver , Polcher Alexandra , Priller Josef , Rauchmann Boris , Rösch Christina , Rudolph Janna , Schneider Anja , Spottke Annika , Spruth Eike Jakob , Teipel Stefan , Vukovich Ruth , Wagner Michael , Wiltfang Jens , Wolfsgruber Steffen , Duezel Emrah , Jessen Frank ,   for the DELCODE Study Group
Published: October 2020

Background

Early identification of individuals at risk of dementia is mandatory to implement prevention strategies and design clinical trials that target early disease stages. Subjective cognitive decline (SCD) and neuropsychiatric symptoms (NPS) have been proposed as potential markers for early manifestation of Alzheimer’s disease (AD). We aimed to investigate the frequency of NPS in SCD, in other at-risk groups, in healthy controls (CO), and in AD patients, and to test the association of NPS with AD biomarkers, with a particular focus on cognitively unimpaired participants with or without SCD-related worries.

Methods

We analyzed data of n = 687 participants from the German DZNE Longitudinal Cognitive Impairment and Dementia (DELCODE) study, including the diagnostic groups SCD (n = 242), mild cognitive impairment (MCI, n = 115), AD (n = 77), CO (n = 209), and first-degree relatives of AD patients (REL, n = 44). The Neuropsychiatric Inventory Questionnaire (NPI-Q), Geriatric Depression Scale (GDS-15), and Geriatric Anxiety Inventory (GAI-SF) were used to assess NPS. We examined differences of NPS frequency between diagnostic groups. Logistic regression analyses were carried out to further investigate the relationship between NPS and cerebrospinal fluid (CSF) AD biomarkers, focusing on a subsample of cognitively unimpaired participants (SCD, REL, and CO), who were further differentiated based on reported worries.

Results

The numbers of reported NPS, depression scores, and anxiety scores were significantly higher in subjects with SCD compared to CO. The quantity of reported NPS in subjects with SCD was lower compared to the MCI and AD group. In cognitively unimpaired subjects with worries, low Aß42 was associated with higher rates of reporting two or more NPS (OR 0.998, 95% CI 0.996–1.000, p < .05).

Conclusion

These findings give insight into the prevalence of NPS in different diagnostic groups, including SCD and healthy controls. NPS based on informant report seem to be associated with underlying AD pathology in cognitively unimpaired participants who worry about cognitive decline.

Trial registration

German Clinical Trials Register DRKS00007966. Registered 4 May 2015.
Application of autologous endometrial mesenchymal stromal/stem cells increases thin endometrium receptivity: a case report
Authors: Sapozhak I. M. , Gubar О. S. , Rodnichenko A. E. , Zlatska A. V.
Published: October 2020

Background

Pregnancy in cycles with the use of assisted reproductive technologies is possible only with the availability of good-quality embryos and a healthy receptive endometrium. The problem of lack of sensitivity of the endometrium is related to the syndrome of thin endometrium, which is caused by a number of factors. However, there is no single protocol for the treatment of this syndrome, the return/improvement of normal functionality of endometrial tissue, and obtaining the desired pregnancy.

Case presentation

We report a case of a 38-year-old Ukrainian woman with a number of unsuccessful tries at pregnancy in cycles with the use of assisted reproductive technologies. We describe a clinical case of the use of mesenchymal stem cells of the human endometrium for a woman with thin endometrial syndrome to increase its receptivity for pregnancy. The basic steps of patient management, protocol of sampling material for obtaining a cell product based on endometrial stem cells, their basic morphofunctional characteristics, and post-treatment procedures to obtain the desired pregnancy are described.

Conclusion

Application of autologous endometrial mesenchymal stem cells increases endometrial receptivity and the chance for pregnancy with use of assisted reproductive technologies.
Existence of positive periodic solutions for super-linear neutral Liénard equation with a singularity of attractive type
Authors: Zhu Yu
Published: October 2020

In this paper, the existence of positive periodic solutions is studied for super-linear neutral Liénard equation with a singularity of attractive type$$ \bigl(x(t)-cx(t-\sigma)\bigr)''+f\bigl(x(t) \bigr)x'(t)-\varphi(t)x^{\mu}(t)+ \frac{\alpha(t)}{x^{\gamma}(t)}=e(t), $$(x(t)−cx(t−σ))″+f(x(t))x′(t)−φ(t)xμ(t)+α(t)xγ(t)=e(t),where$f:(0,+\infty)\rightarrow R$f:(0,+∞)→R,$\varphi(t)>0$φ(t)>0and$\alpha(t)>0$α(t)>0are continuous functions withT-periodicity in thetvariable,c,γare constants with$|c|<1$|c|<1,$\gamma\geq1$γ≥1. Many authors obtained the existence of periodic solutions under the condition$0<\mu\leq1$0<μ≤1, and we extend the result to$\mu>1$μ>1by using Mawhin’s continuation theorem as well as the techniques of a priori estimates. At last, an example is given to show applications of the theorem.
Fractional Fourier transform and stability of fractional differential equation on Lizorkin space
Authors: Unyong Bundit , Mohanapriya Arusamy , Ganesh Anumanthappa , Rajchakit Grienggrai , Govindan Vediyappan , Vadivel R. , Gunasekaran Nallappan , Lim Chee Peng
Published: October 2020

In the current study, we conduct an investigation into the Hyers–Ulam stability of linear fractional differential equation using the Riemann–Liouville derivatives based on fractional Fourier transform. In addition, some new results on stability conditions with respect to delay differential equation of fractional order are obtained. We establish the Hyers–Ulam–Rassias stability results as well as examine their existence and uniqueness of solutions pertaining to nonlinear problems. We provide examples that indicate the usefulness of the results presented.
Relationship between large-scale ionospheric field-aligned currents and electron/ion precipitations: DMSP observations
Authors: Xiong Chao , Stolle Claudia , Alken Patrick , Rauberg Jan
Published: October 2020

In this study, we have derived field-aligned currents (FACs) from magnetometers onboard the Defense Meteorological Satellite Project (DMSP) satellites. The magnetic latitude versus local time distribution of FACs from DMSP shows comparable dependences with previous findings on the intensity and orientation of interplanetary magnetic field (IMF) By and Bz components, which confirms the reliability of DMSP FAC data set. With simultaneous measurements of precipitating particles from DMSP, we further investigate the relation between large-scale FACs and precipitating particles. Our result shows that precipitation electron and ion fluxes both increase in magnitude and extend to lower latitude for enhanced southward IMF Bz, which is similar to the behavior of FACs. Under weak northward and southward Bz conditions, the locations of the R2 current maxima, at both dusk and dawn sides and in both hemispheres, are found to be close to the maxima of the particle energy fluxes; while for the same IMF conditions, R1 currents are displaced further to the respective particle flux peaks. Largest displacement (about 3.5°) is found between the downward R1 current and ion flux peak at the dawn side. Our results suggest that there exists systematic differences in locations of electron/ion precipitation and large-scale upward/downward FACs. As outlined by the statistical mean of these two parameters, the FAC peaks enclose the particle energy flux peaks in an auroral band at both dusk and dawn sides. Our comparisons also found that particle precipitation at dawn and dusk and in both hemispheres maximizes near the mean R2 current peaks. The particle precipitation flux maxima closer to the R1 current peaks are lower in magnitude. This is opposite to the known feature that R1 currents are on average stronger than R2 currents.
Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer
Authors: Wang Huan , Chong Tie , Li Bo-Yong , Chen Xiao-San , Zhen Wen-Bo
Published: October 2020

Background

Kidney cancer is one of the most common cancers in the world. It is necessary to clarify its underlying mechanism and find its prognostic biomarkers. Current studies showed that SHMT2 may be participated in several kinds of cancer.

Methods

Our studies investigated the expression of SHMT2 in kidney cancer by Oncomine, Human Protein Atlas database and ULCAN database. Meanwhile, we found its co-expression gene by cBioPortal online tool and validated their relationship in A498 and ACHN cells by cell transfection, western blot and qRT-PCR. Besides these, we also explored their prognostic values via the Kaplan–Meier plotter database in different types of kidney cancer patients.

Results

SHMT2 was found to be increased in 7 kidney cancer datasets, compared to normal renal tissues. For the cancer stages, ages and races, there existed significant difference in the expression of SHMT2 among different groups by mining of the UALCAN database. High SHMT2 expression is associated with poor overall survival in patients with kidney cancer. Among all co-expressed genes, NDUFA4L2 and SHMT2 had a high co-expression efficient. SHMT2 overexpression led to the increased expression of NDUFA4L2 at both mRNA and protein levels. Like SHMT2, overexpressed NDUFA4L2 also was associated with worse overall survival in patients with kidney cancer.

Conclusion

Based on above results, overexpressed SHMT2 and its co-expressed gene NDUFA4L2 were all correlated with the prognosis in kidney cancer. The present study might be benefit for better understanding the clinical significance of SHMT2 and provided a potential therapeutic target for kidney cancer in future.
Islands and the world from an anthropological perspective
Authors: Ma Guoqing
Published: October 2020

Island studies play an important role in the development of anthropology. It is of academic value and practical significance to understand the island world as the field where multiple modernization forces and globalization interwine. This paper explores the intricate and diverse connections between continental and marine culture from a perspective of “viewing the world through the island”. In terms of overall diversity and exoteric mobility, this paper reviews the various aspects of island studies, examines the internal and external transformation of islands within land-sea interaction, and analyzes the dynamic historical process of the island world’s involvement in the global network, which blends and integrates various cultural elements of the external world. In the context of globalization, the island world is undergoing dramatic changes and in coping with them generating its new features.
COVID-19 deaths in people with intellectual disability in the UK and Ireland: descriptive study
Authors: Perera Bhathika , Laugharne Richard , Henley William , Zabel Abigail , Lamb Kirsten , Branford David , Courtanay Ken , Alexander Regi , Purandare Kiran , Wijeratne Anusha , Radhakrishnan Vishwa , McNamara Eileen , Daureeawoo Youshan , Sawhney Indermeet , Scheepers Mark , Taylor Gordon , Shankar Rohit
Published: October 2020

Background

Rapid spread of coronavirus disease 2019 (COVID-19) has affected people with intellectual disability disproportionately. Existing data does not provide enough information to understand factors associated with increased deaths in those with intellectual disability. Establishing who is at high risk is important in developing prevention strategies, given risk factors or comorbidities in people with intellectual disability may be different to those in the general population.

Aims

To identify comorbidities, demographic and clinical factors of those individuals with intellectual disability who have died from COVID-19.

Method

An observational descriptive case series looking at deaths because of COVID-19 in people with intellectual disability was conducted. Along with established risk factors observed in the general population, possible specific risk factors and comorbidities in people with intellectual disability for deaths related to COVID-19 were examined. Comparisons between mild and moderate-to-profound intellectual disability subcohorts were undertaken.

Results

Data on 66 deaths in individuals with intellectual disability were analysed. This group was younger (mean age 64 years) compared with the age of death in the general population because of COVID-19. High rates of moderate-to-profound intellectual disability (n = 43), epilepsy (n = 29), mental illness (n = 29), dysphagia (n = 23), Down syndrome (n = 20) and dementia (n = 15) were observed.

Conclusions

This is the first study exploring associations between possible risk factors and comorbidities found in COVID-19 deaths in people with intellectual disability. Our data provides insight into possible factors for deaths in people with intellectual disability. Some of the factors varied between the mild and moderate-to-profound intellectual disability groups. This highlights an urgent need for further systemic inquiry and study of the possible cumulative impact of these factors and comorbidities given the possibility of COVID-19 resurgence.
Infection Prevention and Control Measures at the Children Hospital Lahore: A My Child Matters Collaborative Project
Authors: Faizan Mahwish , Caniza Miguela A. , Anwar Saadia , Kashif Rahat-ul-Ain , Saleem Rabia , Javed Humera , Zafar Aizza , Taj Mary Munaza , Hameed Ambreen , Homsi Maysam , Rathore Ahsan Waheed , Sadiq Masood , Gonzalez Miriam , Zaidi Alia
Published: October 2020

PURPOSE

Infection prevention among children with cancer is a major challenge at Children Hospital Lahore (CHL), a public health care facility in Pakistan with 1,000 new pediatric cancer admissions annually. The objective has been to reduce infections through collaboration between CHL and the St Jude Children’s Hospital Global Infectious Disease program via a grant by the Sanofi Espoir foundation through the My Child Matters program. The aim of the current study was to describe the effect of the collaborative improvement strategy on existing infection prevention and control (IPC) standards at CHL.

MATERIALS AND METHODS

Our work was a prospective before-and-after study to improve IPC standards. We compared the WHO Hand Hygiene Self-Assessment Framework and four modules of the St Jude modified Infection Control Assessment Tool (ICAT) scores over a 3-year period. Our strategy included creating a multidisciplinary team of pediatric oncologists, infectious disease physicians, nurses, a microbiologist, and a data manager; engaging in monthly online IPC mentoring sessions with St Jude Children’s Hospital Global Infectious Disease program and My Child Matters mentors; performing daily inpatient health care–associated infection surveillance rounds; and performing regular hand hygiene training and compliance audits.

RESULTS

Baseline needs assessment showed health care–associated infections identified by positive blood cultures as 8.7 infections per 1,000 patient-days. Deficient hand hygiene supplies, health education measures, and bed sharing of neutropenic patients were identified as major challenges. Our hand hygiene facility level, per WHO scores, increased from Inadequate to Intermediate/Consolidation by the end of the 3-year implementation (122 v 352 WHO Hand Hygiene Self-Assessment Framework scores). The sink:bed and hand sanitizer:bed ratios improved to 1:6 and 1:1, respectively. The ICAT general infection control module increased by 40% (45 v 78 ICAT scores) and hygiene compliance improved by 20%.

CONCLUSION

Implementing a collaborative improvement strategy improved IPC standards in our center, which can be easily replicated in other pediatric oncology centers in lower- and middle-income countries.
Safety and Evidence of Off-Label Use of Approved Drugs at the National Cancer Center Hospital in Japan
Authors: Bun Seiko , Yonemori Kan , Sunadoi Hiroko , Nishigaki Rena , Noguchi Emi , Okusaka Takuji , Nishida Toshirou , Fujiwara Yasuhiro
Published: October 2020

PURPOSE:

In Japan, for pharmaceutical products to be covered by public medical insurance, their efficacy and safety must first be confirmed in clinical trials. To our knowledge, this study is the first investigation into the off-label use of pharmaceutical products at a high-volume cancer treatment center in Japan. The objective of this study is to explore the framework necessary for future pharmaceutical development and regulatory approval in the field of oncology by surveying the frequency of and indications for off-label use of pharmaceutical products at the National Cancer Center Hospital in Tokyo, Japan.

MATERIALS AND METHODS:

The pharmaceutical products used off-label in daily practice from 2003 to 2015 at the National Cancer Center Hospital were retrospectively examined based on applications that had been submitted to an internal review committee requesting off-label use.

RESULTS:

A total of 1,390 applications were submitted during the study period. The most frequently used supporting documents were the results of phase II trials, followed by case series and phase III trials. The cancer most frequently treated with off-label drugs was sarcoma (15.1%), followed by urologic cancer (9.2%) and GI cancer (7.6%).

CONCLUSION:

As reported in previous studies, pharmaceutical products were generally used off-label for the treatment of rare cancers, for which large-scale clinical trials are difficult to conduct. Continued discussion of the types of frameworks that are needed to guide pharmaceutical development is necessary.
The Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development
Authors: Echevarría-Andino Martha L. , Allen Benjamin L.
Published: October 2020

The Hedgehog (HH) pathway controls multiple aspects of craniofacial development. HH ligands signal through the canonical receptor PTCH1, and three co-receptors: GAS1, CDON and BOC. Together, these co-receptors are required during embryogenesis to mediate proper HH signaling. Here we investigated the individual and combined contributions of GAS1, CDON and BOC to HH-dependent mammalian craniofacial development. Notably, individual deletion of either Gas1 or Cdon results in variable holoprosencephaly phenotypes, even on a congenic background. In contrast, we find that Boc deletion results in facial widening that correlates with increased HH target gene expression. Additionally, Boc deletion in a Gas1 null background partially ameliorates the craniofacial defects observed in Gas1 single mutants; a phenotype that persists over developmental time, resulting in significant improvements to a subset of craniofacial structures. This contrasts with HH-dependent phenotypes in other tissues that significantly worsen following combined deletion of Gas1 and Boc. Together, these data indicate that BOC acts as a multi-functional regulator of HH signaling during craniofacial development, alternately promoting or restraining HH pathway activity in a tissue-specific fashion.
Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2−/− animals
Authors: Sheriff Lozan , Khan Reenam S. , Saborano Raquel , Wilkin Richard , Luu Nguyet-Thin , Gunther Ulrich L. , Hubscher Stefan G. , Newsome Philip N. , Lalor Patricia F.
Published: October 2020

Alcoholic hepatitis (AH) is the dramatic acute presentation of alcoholic liver disease, with a 15% mortality rate within 28 days in severe cases. Research into AH has been hampered by the lack of effective and reproducible murine models that can be operated under different regulatory frameworks internationally. The liquid Lieber-deCarli (LdC) diet has been used as a means of ad libitum delivery of alcohol but without any additional insult, and is associated with relatively mild liver injury. The transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) protects against oxidative stress, and mice deficient in this molecule are suggested to be more sensitive to alcohol-induced injury. We have established a novel model of AH in mice and compared the nature of liver injury in C57/BL6 wild-type (WT) versus Nrf2−/− mice. Our data showed that both WT and Nrf2−/− mice demonstrate robust weight loss, and an increase in serum transaminase, steatosis and hepatic inflammation when exposed to diet and ethanol. This is accompanied by an increase in peripheral blood and hepatic myeloid cell populations, fibrogenic response and compensatory hepatocyte regeneration. We also noted characteristic disturbances in hepatic carbohydrate and lipid metabolism. Importantly, use of Nrf2−/− mice did not increase hepatic injury responses in our hands, and female WT mice exhibited a more-reproducible response. Thus, we have demonstrated that this simple murine model of AH can be used to induce an injury that recreates many of the key human features of AH – without the need for challenging surgical procedures to administer ethanol. This will be valuable for understanding of the pathogenesis of AH, for testing new therapeutic treatments or devising metabolic approaches to manage patients whilst in medical care.

This article has an associated First Person interview with the joint first authors of the paper.
Urea/Thiourea Based Optical Sensors for Toxic Analytes: A Convenient Path for Detection of First Nerve Agent (Tabun)
Authors: Kumar Vinod
Published: October 2020

In the realm of supramolecular chemistry, the development in synthetic receptors for harmful analytes has attracted substantial attention in recent decades due to the fact that a huge number of chemical and biological processes involve molecular recognition of these species. It is therefore important to develop methods/techniques for sensing such analytes. To design and develop a chemical sensor, one or more urea/thiourea fragments are incorporated in acyclic, cyclic, or polymeric frameworks that are directly attached to the signaling units as well as spacers. Being a good hydrogen bond donor, urea/thiourea has an excellent binding affinity for anionic and neutral species. In our research, we designed and developed urea/thiourea based novel receptors decorated with finely tuned signaling units and spacers for the detection of fluoride, cyanide, and tabun (first nerve agent). The developed chromogenic and fluorogenic hosts instantaneously detect these toxic anions and analytes with exceptional selectivity over other interfering agents. Inspired by the multianalyte detection approach, we further aimed to explore novel chromo-fluorogenic receptors that not only detect these analytes but also differentiate from one another. Urea/thiourea motifs have been extensively used in the chemosensing of anionic and neutral analytes, supramolecular catalysis, and supramolecular medicinal chemistry. In this Account, these studies have also been briefly summarized.
An AIE-based Fluorescent Probe for Detection of Picric Acid in Water
Authors: Wang Zhonglin , Si Shufan , Luo Zijie , Qin Tianyi , Xu Zhongyong , Liu Bin
Published: October 2020

Detection of picric acid (PA) is essential for public security, environment protection and human health. In this work, we have designed and synthesized a photostable fluorescent probe with aggregation-induced emission character enabling rapidly sensing PA in pure water. This probe showed high sensitivity and selectivity to PA with the limit of detection as 320 nM, and was also utilized as paper strips for PA detection.
Design of Interfaces and Phase Interfaces on Cathode Catalysts for Polymer Electrolyte Fuel Cells
Authors: Inoue Gen , Takenaka Sakae
Published: October 2020

Development of heterogeneous catalysts for energy conversion has been required to solve environmental issues arising from the combustion of fossil fuels. Polymer electrolyte fuel cells (PEFC) are promising power generation devices alternative to the internal combustion engine. PEFC performance is strongly dependent on the catalytic activity for the oxygen reduction reaction at the cathode because of sluggish kinetics. Thus, highly active and durable Pt-based cathode catalysts with tailored geometrical and electronic structures have been widely developed. The Pt-based catalysts have been used in membrane-electrode-assembly (MEA) of the PEFC, where the catalyst particles are integrated as the catalyst layers a few micrometers thick. Porous structure and morphology in the catalyst layers with nanometer to micrometer scale should be designed for the facile diffusion of oxygen, proton and water. In this highlight review, we provide an overview for the development of catalysts and catalyst layers with high activity and durability for the PEFC.
Modern technological equipment for leather production
Authors: Chursin Vyacheslav , Haustov Vladislav
Published: October 2020

The tutorial shows the design, basic and kinematic diagrams of technological equipment used in the leather industry. Comparative technical characteristics of modern machines and units produced by various companies are presented. Defects that occur during improper operation or malfunction of individual components of technological equipment are considered. Meets the requirements of the Federal state educational standards of higher education of the latest generation. For undergraduate and graduate students of the 29.03.01 and 29.04.01 "technology of light industry products", studying the disciplines "Design, technical re-equipment and reconstruction of light industry enterprises", "fundamentals of machine science in the production of leather and fur", "Modern technological equipment for leather and fur production".
Technology of pedagogical goal setting
Authors: Turbovskoy Yakov , Filinova Vera
Published: October 2020

Based on the theory of pedagogical goal-setting, the monograph reveals the ways to achieve goals as a planned result obtained at each lesson, during the transition from one topic to another, during the school year and all years of study. This book, which includes the technology of pedagogical goal-setting, solves a two-pronged problem: it provides an opportunity to improve the professional skills of each teacher and contributes to improving the effectiveness of managing the development of education from the point of view of the requirements of modern state standards and curricula as an integral process.
For teachers, head teachers, Directors of educational institutions, methodologists and heads of educational bodies.
Complaints against Medical Rescue Teams and their members submitted to District and Regional Courts within the area of District Court in Kielce and Katowice in the years 2014-2019
Authors: Musiał Paweł
Published: October 2020

Today's medical rescue in pre-hospital care is a series of ongoing legal and administrative changes and regulations, increasing the scope of competence of medical rescuers working in - basic Medical Rescue Teams. The decreasing number of specialist Emergency Medical Teams, in the continuous process of system changes, makes paramedics face even greater responsibility in terms of performing medical rescue operations and possible errors that hang over paramedics in their everyday work. Demanding patients and their families, the growing number of many private insurance claim law firms dealing with the medical cases is another piece of the puzzle that today sets a bruising path in the search for property benefits and compensation in the form of lawsuits brought to Medical Rescue Teams and their members.
Dry socket - clinical procedures review
Authors: Nieścior Hubert , Bator Damian , Wójcik Magdalena , Szarpak Julita , Dąbrowska Justyna , Sereda Dominika
Published: October 2020

Introduction: Dry socket is a complication following extraction surgery. It usually appears between days 1 and 3 after extraction. The partially disorganized clot breaks down and healing is impaired.Material and methods: The latest reports available on the dry socket and its treatment using various methods were used. The NCBI database was used for this purpose, using the terms "dry socket" and "dry socket treatment".State of knowledge: Dry socket occurs as a complication in 1-5% of extraction sockets, while in the case of sockets after 3 mandibular molars, the percentage is as high as 38%. Risk factors may include: insufficient blood supply to the tissue, use of an excessive amount of anesthetic, hormonal contraception, smoking, traumatic surgery, failure to follow the doctor's instructions regarding the postoperative procedure. Chlorhexidine, warm saline, platelet plasma, hyaluronic acid-impregnated collagen sponges, resorbable collagen membranes and eugenol with lidocaine on Penghawar Djambi carrier can be used to treat dry socket.Summary: Dry socket is a medical condition. The unification of treatment recommendations is the goal of research on tools used in the context of a dry socket. Evaluation of profits and losses will allow to unify the recommendations and reduce the incidence of this complication.
The influence of perinatal and postpartum depression on child development and its functioning in adult life
Authors: Szarpak Julita , Bator Damian , Wójcik Magdalena , Nieścior Hubert , Dąbrowska Justyna , Milanowska Joanna
Published: October 2020

Introduction and purpose: During pregnancy, the physiology of the mother's organism undergoes many changes, and this also applies to the sphere of mental health. Difficulties in adapting to the new situation, metabolic, genetic and environmental factors may predispose expectant mothers to develop depression spectrum disorders. The purpose of this study is, based on the available data, to summarize the consequences of maternal depressive disorder development during pregnancy and postpartum.Brief description of the state of knowledge: The development of mental disorders by a pregnant woman has a documented negative impact on the course of pregnancy and on the maturation of the fetus. The consequences of excessive stress, anxiety and depression during pregnancy include, among others, an increased risk of premature birth, abnormalities in the development of the nervous system of the fetus, and difficulties in acquiring speech skills in the future life. In mothers, perinatal depression increases the risk of severe psychosis or substance abuse such as alcohol and drugs.Conclusions: A number of serious complications, both for a woman and a child, related to the occurrence of mental disorders during pregnancy, prompts to focus on the problem of appropriate care for future mothers, not only in physical terms. An important issue is the standardization of diagnostic procedures and the dissemination of screening tests for maternity depression.
Mantle Cell Lymphoma: Effectiveness of Maintenance Ibrutinib – Case Report
Authors: Krasowska Danuta , Szczepnek Aleksandra , Kozioł Magdalena , Szczepanek-Wąsik Ewa
Published: October 2020

Mantle cell lymphoma is a rare subtype of non- Hodgkin lymphoma with life-threatening course of disease. It mostly affects older adults in their sixth or seventh decade of life with male to female predominance of 3 to 1. It prognosis is very poor and the treatment is demanding. The golden standard therapy for younger, fit patients <65 years is chemoimmunotherapy such as R-CHOP/R-DHAP rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, prednisolone, dexamethasone, cytarabine and cisplatin) followed by BEAM chemotherapy (carmustine, etoposide, cytarabine, melphalan)  and autologous- stem-cell transplant (ASCT).  Nevertheless MCL is mainly recognized in patients of average age 67 in whom comorbidities often play a crucial role during treatment.A 56- years old patient was admitted to the Department of Hematooncology and Bone Marrow Transplantation with clinical symptoms such as heavy night sweats, generalized enlargement of lymph nodes, massive weight loss, dyspnea and fatigue. Initial physical examination and imaging showed enormous hepatosplenomegaly, mass in the lungs and fluid in the pleural cavity.The patients underwent chemioimmunotherapy consolidated with an autologous stem cell transplant. To date, the patient is on maintenance treatment with ibrutinib.
The meaning of blood and cerebrospinal fluid biomarkers in early diagnosis of Alzheimer's disease
Authors: Szarpak Julita , Dalmata Weronika , Gąbka Ilona , Madycka Daria , Wysokińska Olga
Published: October 2020

Introduction and purpose: Alzheimer's disease (AD) belongs to the group of neurodegenerative diseases and is the leading cause of dementia worldwide. Its development includes the impact of genetic, metabolic and environmental factors. Despite high prevalence of Alzheimer’s disease and dynamic development of medical science, there is currently no clinically proven causal treatment. The proposed therapies are only symptomatic. However, there is a wide set of substances known as biomarkers that are detected in the blood or in the cerebrospinal fluid (CSF) in the stages preceding full-blown Alzheimer's disease.Brief description of the state of knowledge: In order to obtain material for CSF examination, a lumbar puncture must be performed. It is an invasive procedure, with the risk of complications such as bleeding into the spinal cord, infection or even nerve damage. Obtaining a blood sample for testing specific indicators is less invasive and more widely available. Currently, the diagnostic significance of commonly known markers arising in the progress of the AD pathological process, such as amyloid β, tau protein and its phosphorylated form or β-secretase, is being investigated. As the knowledge on the pathogenesis of AD grows, further markers such as ubiquitin, micro RNA or plasma neurofilament light are tested.Conclusions: There is a collection of biomarkers that can perform a diagnostic function for Alzheimer's disease. Due to the advantages of blood and plasma testing, basing the diagnosis of early forms of AD on these tests seems to be particularly interesting. However, the use of biomarkers on a global scale requires further research and test standardization, as well as the development of guidelines for their interpretation.
Lipid disorders in blue-collar workers in Lubelskie region
Authors: Jankowska Paula , Jankowski Krzysztof , Rudnicka-Drożak Ewa , Kamiński Piotr
Published: October 2020

IntroductionLipid disorders are the most important risk factor of cardiovascular disease (CVD). For clinical practice and assessment of patient`s cardiovascular risk the most relevant is to determine plasma concentration of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C). Blue-collar workers are a group of patients with higher estimated cardiovascular risk than other workers groups.The aim of the studyThe aim of the study was to asses prevalence of lipid disorders in blue-collar workers from Lubelskie region.Material and methodsThe method of this paper was to perform a retrospective analysis of data provided by the National Health Fund. The study population enclosed patients aged 35, 40, 45, 50, 55 included in the Cardiovascular Disease Prevention Program held in Primary Healthcare (PH) setting on the area of Lubelskie region in years 2008-2018. Patients analyzed were blue-collar workers. The chi-square test was used to test the relationship between the two qualitative features and the Pearson linear correlation between the quantitative features. The analyzes were performed using the IBM SPSS Statistics for Windows, version 25 program (IBM Corp., Armonk, N.Y., USA). The significance level was assumed to be α = 0,05.ResultsIn 26 226 patients hyperlipidemia was observed in 65,6% and LDL cholesterol levels higher than 115 mg/dl in 52,8% of patients. The mean total cholesterol serum concentration was 203,8 mg/dl, LDL cholesterol - 120,1 mg/dl and median triglycerides concentration – 101,0 mg/dl.ConclusionsHyperlipidemia was a common problem in blue-collar workers in Lubelskie region in years 2008-2018. Intense prophylactic actions are needed to reduce cardiovascular risk of this group of population.
The relationship between the occurrence of psoriasis and depression
Authors: Obuchowska Karolina , Obuchowska Aleksandra , Standyło Arkadiusz , Wójcik Justyna , Ozga Alicja
Published: October 2020

Psoriasis (skin psoriasis, PsO) is a chronic auto‐immune skin inflammatory condition. In about one-third of cases, the joints are affected (psoriatic arthritis, PsA). Both conditions, especially PsA, profoundly impact patients' health-related quality of life.  This disease affects between 2% and 3% of the population. The onset occurs before the age of 40 as a sharply demarcated scaly, red skin lesions, most often on the elbows, knees, scalp, hands, feet and joints considering osteoarticular involvement. Patients are suffering from itching, irritations, stinging and pain. Etiology of this disease is multifactorial, with genetic and environmental involvement, psychological stress and depression being the key factors considering the onset, flare or therapeutic resistance of psoriatic disease. The purpose of this article is to review and analyze how depression and stress affect the life of patients with psoriasis and in which way prevention could play a role regarding the evolution of this disease.Proinflammatory cytokines such as interleukin (IL)‐1 and IL‐6 are elevated in both psoriasis and depression, indicating that the inflammatory process may be involved in the progression of both diseases. Psoriasis has long been recognized to be associated with potentially adverse effects on mental health. However, there have been relatively few studies evaluating psychological outcomes in patients with psoriasis.Depression and stress decrease the quality of life, psoriasis being the last drop in the glass, with bimodal intensification of these pathologies. Quality of life in patients with psoriasis is directly associated with the severity of the disease, family status, work status and stigmatization.
Beriberi disease – a picture of thiamine deficiency in underdeveloped and highly developed countries
Authors: Blicharz Agnieszka , Marzęda Magdalena , Drozd Małgorzara , Czarnota Jakub , Piecewicz-Szczęsna Halina
Published: October 2020

Introduction and purpose: Thiamin (Vitamin B1) is a water-soluble vitamin. It plays an important role in many biological processes, mainly in glucose metabolism. Its deficiency is called beriberi disease. Beriberi was discovered at the turn of the 19th and 20th centuries and is now a disease that occurs in both underdeveloped and highly developed countries.Brief description of the state of knowledge: Thiamine deficiency can affect the cardiovascular, nervous and immune systems, which is seen as dry, wet, fulminant beriberi or as Wernicke-Korsakoff syndrome. Worldwide, vitamin B1 deficiency is most commonly reported in populations where rice and ground grains are the main food source, but also in patients with chronic alcohol abuse, diabetes, gastrointestinal surgery, cancer, and patients undergoing chronic diuretic therapy, which increases urine loss.Summary: Treatment of beriberi disease consists in supplementing vitamin B1 in appropriate doses. The symptoms of thiamine deficiency are non-specific, however, early diagnosis and initiation of vitamin administration quickly lead to clinical improvement. It should be remembered that thiamine deficiency is often not included in the differential diagnosis of complaints reported by patients. This may be due to the belief that diets in European countries containing food products enriched with vitamins exclude clinically evident micronutrient deficiencies.
Risk factors for gallbladder cancer
Authors: Suchodolska Magdalena , Świerczyńska Blanka , Undziakiewicz Adrian , Smoluchowski Krzysztof , Sekuła Michał
Published: October 2020

Introduction and purpose:                Gallbladder cancer is the most common neoplasm of the bile duct. Early GBC is usually asymptomatic, but is prone to early metastases. This means that most GBC cases are diagnosed very late, and this contributes to the poor prognosis of this disease. Less than 20% of GBC cases qualify for a potentially curable surgical resection at the moment of diagnosis. The article is an overview of available literature describing current epidemiology and etiological risk factors associated with the development of gallbladder cancer (GBC). We performed a review of the articles on the etiology and GBC carcinomatosis.Brief description of the state of knowledge:          We divided risk factors of GBC into independent and dependent. The independent risk factors are: age, sex, cholelithiasis, porcelain gallbladder, gallbladder polyp, anomalous junction of the pancreaticobiliary ductal system, high BMI and obesity, and Helicobacter pylori. On the other hand, the dependent risk factors are: age of first pregnancy and number of pregnancies, xanthogranulomatous cholecystitis, lipid peroxidation products, and aflatoxins. Gallbladder cancer appears to be a multifactorial disease, but the main risk factors are: cholelithiasis and porcelain gallbladder developing from chronic cholecystitis.Conclusions:              For understanding the etiopathology of GBC more studies have to be conducted, what may allow to establish reliable biomarkers and invent new preventive strategies and more effective treatment.
Diagnosis and management of lipoedema – a review paper
Authors: Szypłowska Małgorzata , Gorecka Adrianna , Kuś Adrian , Zaremba Bartłomiej , Obel Michał
Published: October 2020

Lipoedema is a chronic progressive disorder of adipose tissue leading to an enlargement of lower extremities. It is considered to be rare; however, the prevalence of the disease is underestimated because it is commonly misdiagnosed as obesity or lymphedema and the general awareness is poor. The etiology of the disorder is considered to be multifarious, including genetic inheritance, hormonal imbalance and microcirculation alterations. Diagnosis is mainly based on medical history and physical examination. Management of lipoedema is focused on reducing the symptoms, improving the quality of life and preventing further progression of the disease. The aim of this paper is to raise the awareness of the disease and provide appropriate clinical guidance for the assessment of lipoedema. We searched through the PubMed/MEDLINE database and took into consideration all of the results available as of 6September, 2020 and outlined the current evidence regarding lipoedema epidemiology, etiology, clinical presentation, differential diagnosis, and management. Better understanding of lipoedema is crucial for establishing an early diagnosis and a proper treatment, which in turn will reduce the psychological and physical implications associated with the disease.
Sleep disorders in patients with neoplasm
Authors: Pawlicki Mateusz , Łopuszyńska Anna , Kozioł Magdalena , Krasa Aleksandra , Piekarska Ewa , Piecewicz-Szczęsna Halina
Published: October 2020

Introduction: Sleep disorders are a big group of disturbances affecting many people in the world. They can appear as insomnia, interrupted sleep, worsened sleep quality or trouble falling asleep. Although they may not seem very dangerous, they lead to various unpleasant complications and even diseases. Cancer is said to be one of the possible sources of the problem.Results: Studies show relationship between cancer and sleep disruptions. They are frequent in lung, head and neck, gynecologic and breast neoplasms. Patients report higher scores of Pittsburgh Sleep Quality Index, insomnia severity scale and Epworth Sleepiness Scale meaning that they can be considered as poor sleepers. In addition, they often develop psychiatric disorders which are linked with higher risk of sleep problems.Conclusions: According to many research, cancer often comes with somnipathies. It should be taken into consideration when planning oncologic treatment and care to obtain the best effects of the therapy.
Surgical management options for Bartholin’s gland abscess
Authors: Krupa Adrianna , Piasek Ewa
Published: October 2020

Bartholin's glands, also known as greater vestibular glands, are two mucus-secreting glands located in the posterolateral wall of the vagina opening. The function of these glands is to produce mucus that moisturizes the vestibule of vagina. When the outflow path from the gland is blocked, a cyst forms. When the abscess is formed usually it is infections with a polymicrobial background.The most common symptoms of a Bartholin's gland cyst or abscess include pain in the vulva, swelling, difficulty walking, dyspareunia, and fever.The procedure of choice in this case is surgery. The operator can choose from among many possible options, among others there is simple incision and drainage of the cyst, marsupialization, a Word catheter, silver nitrate application, alcohol sclerotherapy, excision and laser CO2 and, as a last resort, surgical removal of the gland.The aim of this study is to review the most common surgical procedures used in Bartholin's gland cyst or abscess.