bluuebunny/crossref_metadata_2025 huggingface dataset:
The Rules of Conflict-of-Interest Management for Public Officials under the “British Model”: A Content Analysis Based on 19 Codes of Ethics
Authors: Li Wenyu
Published: October 2024

The United Kingdom is one of the countries globally known for its high level of integrity and has essentially developed a relatively comprehensive mechanism for preventing and addressing corruption. Effective management of conflicts of interest among public officials is a crucial aspect of corruption prevention in the United Kingdom. The United Kingdom emphasizes establishing a system of ethical norms that encompasses standards for public life more than other nations. By constructing a two-dimensional analysis framework for conflict-of-interest management tools and categories of public officials and utilizing the NVivo14 text analysis tool, we conducted a content analysis of the relevant portions in the British Code of Ethics text concerning managing conflicts of interest among public officials. The study revealed that conflict-of-interest management rules demonstrate a high degree of transparency orientation. The focus is on teaching public officials how to effectively handle conflicts of interest, not just prohibiting or dispossessing them of their private interests. The coordinated use of various management tools tailored to different conflict-of-interest scenarios results in effectively managing conflicts of interest among public officials.
Analysis and Research on Design of Dialect Emoticons from the Perspective of Regional Culture in Yancheng
Authors: Teng Fei , Li Ying
Published: October 2024

In this paper, Yancheng’s local culture is classified through literature research, expert interviews, and popular questionnaires. In the dialect matching of emoticons, the high-frequency text used by Yancheng people is used, and the dialect text ranking table measured by experts is combined to provide the main content for producing and designing emoticons. Based on the analysis model of Yancheng material culture and nonmaterial culture, the image design elements of Yancheng regional emojis with local and high cultural characteristics are extracted from Yancheng regional elements. The Design of emoticons that combine pictures and text emphasizes the expression of awareness, starting with modeling the theme image, color matching, scene props, and so on. The animation emoji industry benefits from this valuable feasibility strategy, and new vitality is added to the development of the animation industry in Yancheng.
The Application and Effectiveness of Interdisciplinary Integration Education in Teaching Interior Design and Environmental Design
Authors: Dong Jian , Ran Meng
Published: October 2024

The innovative interdisciplinary integration teaching of interior design and environmental design courses results from the interaction between the development of disciplines and the needs of the times, individual aesthetic needs, and the optimization of the human habitat. Based on the STEAM teaching theory, the article analyzes the advantages of interdisciplinary integration teaching and establishes the teaching mode for interior design and environmental design courses. Students of interior design at a university were selected as the research object, and a system for evaluating teaching quality was established. The weights of evaluation indexes were solved using the rough set method, and the fuzzy comprehensive evaluation method was combined with it to conduct a thorough evaluation of the interdisciplinary, integrated teaching mode. A comparison experiment was conducted to analyze the effectiveness of the multidisciplinary integration teaching mode. After conducting the teaching comparison experiment, the mean value of the posttest scores for core literacy students in class A is 27.22 points higher than that of class B. The difference in occupational physical, mental, and behavioral literacy weighting is only 0.13%, and the overall evaluation score for the quality of interdisciplinary integrated teaching is 8.183. Introducing multidisciplinary integration teaching can improve students’ interior design abilities and help improve the quality of training in interior design and environmental design talents in colleges and universities.
Research on the Innovation and Effectiveness of the Management Mode of Civic and Political Education in Colleges and Universities in the Intelligent Era
Authors: Wang Yanhui
Published: October 2024

At present, the diversification of values and the diversification of needs of college students are increasingly demanding the innovation of ideological and political education. This study applies big data analysis in the intelligent era to the management of ideological and political education. It innovates the management of ideological and political education in colleges and universities based on big data. Students of University M were selected to conduct teaching experiments. After setting the assessment dimensions of the effect of ideological and political education, ANOVA was applied to compare the differences in the dimensions of the sample students before and after the implementation of the innovative ideological and political education management model. The K-mean method was used to obtain portraits of students with different levels of national identity to analyze further the specific changes in student groups’ civic and political education levels. The students who carried out the innovative Civic Education and Management model significantly improved in national identity, learning motivation, academic level, and its sub-dimensions, and they were 4.50% to 5.32% higher than the comparison students. The national identity level of the sample students is dominated by moderate identity, accounting for 58.67%, and different groups of students have significantly improved in this dimension. This paper’s analysis shows that the innovative model of civic education management based on big data has a nurturing effect.
Application of fuzzy evaluation model in the evaluation system of labor education
Authors: Li Yuanyuan , Wang Yuan
Published: October 2024

The development of labor education in colleges and universities should be linked with the development of society and follow the footsteps of the changing social digital era. This paper provides a theoretical basis for constructing an evaluation system of labor education by elaborating on the new era of labor education. According to the relevant literature and policy documents, the evaluation index system is initially formulated, and the Delphi method is used to revise and improve the initially selected evaluation index system, finally completing the construction of the evaluation index system of labor education. Combining the hierarchical analysis algorithm and fuzzy evaluation model, labor education in colleges and universities is evaluated. The selected evaluation indexes satisfy the criteria of expert opinion concentration (>3.5) and coefficient of variation (<0.25). The weights of the indicators were determined according to the acquired data, and the comprehensive evaluation results of labor education in 985 211 undergraduate colleges were calculated to be excellent grades. The evaluation and analysis results propose three labor education strategies: top-level education design, curriculum operation mechanism, and guarantee mechanism.
A Study of the Adaptability of Adaptive Learning Systems to Individualized Educational Strategies
Authors: Xu Ruihang , Zhang Li , Chollathanrattanapong Jidapa
Published: October 2024

An adaptive learning system is an effective way to realize personalized learning. The article analyzes the process and implementation of adaptive learning and establishes an accurate diagnosis strategy for students’ knowledge levels using an adaptive learning system. The fuzzy preference relation is used to model students’ learning resource preferences mathematically, and GA solves the fuzzy relation to construct adaptive recommendations for learning resources. The knowledge learning status of students is quantified, and the DKVMN-PLC model for learner knowledge tracking is established by combining relevance weights and potential knowledge features. The effectiveness of the above method in promoting personalized adaptive learning among students has been verified using four different types of real datasets. When the number of external learning behavior influences is 250 and the number of learning resources is less than 60, the optimal time of the adaptive resource recommendation algorithm is only 4.453 s. The DKVMN-PLC model performs best on the ASSISTments dataset, with the AUC value improved by 8.5% and 5.3% compared with the DKT and DKT+LSTM models, respectively. Relying on the adaptive learning system provides students with a knowledge-tracking method, which provides a practical path to promote personalized learning.
Evaluation of the effectiveness of robot-assisted teaching in the training room in preschool education
Authors: You Junsheng , Yang Xiaoqing
Published: October 2024

In recent years, the national policy has strongly promoted the integration of artificial intelligence technology and the field of education. In response to the national policy’s call, this paper proposes a robot-assisted teaching model. Taking the coordinate transformation model, velocity motion model, odometry motion model, and visual and auditory recognition model as design principles of the educational robot, the design of the educational robot is materialized by borrowing relevant hardware and programming software. The robot-assisted preschool education teaching model was created to explain the role of educational robots in preschool education. The research subjects were selected, and the teaching effect of robot-assisted preschool education was analyzed by combining theoretical knowledge of statistics. After the experimental intervention, in terms of learning quality, language expression ability, and cooperative literacy, there was a significant difference between the early childhood students in Group B and Group C, with P<0.05. In addition, the mean value of all the satisfaction indices remained above 3.3. Combining all the analyzed results confirms the facilitating role of robot-assisted teaching in preschool education.
Application and Optimization of Multimodal Information Communication in Cultural and Creative Products in the New Media Era
Authors: Deng Qiyi , Xu Dangqing , Zang Qi
Published: October 2024

As one of the most important parts of today’s cultural industry products, the design and presentation form of cultural and creative products have been optimized with the development of new media technology. Based on the multimodal theory, the study constructs a system of cultural and creative products using graph neural networks, attention mechanisms, knowledge maps, and other cultural and creative product design methods. The cultural representation evaluation system of cultural and creative products is constructed using the hierarchical analysis method, and the cultural and creative products designed by the model of this paper are evaluated. Analyze the color of cultural and creative products to examine the performance of this paper’s model on color. By analyzing the user experience score of cultural and creative products, the design effect of this paper’s model is explored. In the evaluation index system of cultural representation of cultural and creative products, the largest proportion of the weight of the criterion layer is the external level (54.68%), and the evaluation index with the largest comprehensive weight is the pattern (27.08%). The cultural and creative products designed by the model of this paper have the largest weight proportion of the value to be modified in pattern and material, which are 36.63% and 24.15%, respectively. The mean value of each of the chromaticity analyses is less than 2, and the mean value of the total color difference is less than 3, indicating that the color performance of the cultural and creative products designed by the model of this paper is excellent. The overall scores of the four types of cultural and creative products designed by the model of this paper are between 3.92 and 4.04 in terms of user experience, and the user experience is better.
Research on Information Technology Integration and Teaching Mode Innovation in Physical Education Teaching in Colleges and Universities
Authors: Diao Naisong , Song Wei , Wang Lina
Published: October 2024

The traditional physical education model is no longer able to meet the needs of current students, and the rise of information technology presents a new opportunity for the innovation of physical education teaching modes. This paper first introduces the application of information technology in physical education, then focuses on the information fusion technology algorithm. It constructs a multi-source information feature level fusion algorithm based on the deep typical correlation analysis algorithm and derives the multi-source feature level fusion (SVM) model from it. The authors have defined the parameters for assessing the credibility of the SVM model. Subsequently, we scrutinize the accuracy of the SVM model, and ultimately, we use this model to analyze and base our innovative opinions on the impact of information integration technology in the sports teaching model. The SVM model achieves its highest accuracy at 93.9% when R = 4, and the data follows a normal distribution with high reliability and validity, allowing for feature-level fusion. 2022 The publication rates of innovative teaching models in sports at different educational stages are 8.78%, 10.12%, 9.49%, and 8.32%, respectively, and the research of innovation in physical education teaching models is positively correlated with the year. Clearly, the innovative physical education teaching model not only utilizes big data fusion technology to tailor instruction to student’s abilities but also accurately understands their learning dynamics through remote monitoring, online learning, virtual reality, and other technologies. This serves as a model for integrating information technology into the innovation of physical education teaching models.
Research on the Role of Artificial Intelligence-Based Student Management Strategies in the Cultivation of Students’ Innovative Ability in Colleges and Universities
Authors: Gao Yacheng , Zhang Lei , Guo Wenfei , Liu Hao
Published: October 2024

Under the background of the new era, the trend of diversification of college students’ group behavior is obvious; the traditional student management mode cannot meet the needs of education and teaching in the new era of colleges and universities, and the reform of student management is imminent. This paper analyzes 245 students from University A in Shanghai using questionnaires to study the differences in their innovation ability among different genders, ages, and educational levels. PLS-SEM and correlation analysis methods were employed to investigate the factors that influence students’ innovation ability. The overall innovative capacity of students is satisfactory, except for the innovative capacity of results, which requires more improvement. In the analysis of differences in innovation ability, each mean value of undergraduate innovation ability is greater than the mean value of specialized innovation ability, such as thinking innovation: undergraduate M=3.795>specialized M=3.642 (P<0.05), which shows that academic qualifications are a part of the influence of students’ innovation ability. Secondly, “the intelligent level of the management team”, “the popularity of the campus network,” and “the interaction degree of intelligent management platform” are significantly correlated with “innovation ability” (P<0.05) is significantly correlated (P>0.01). Among the six influence paths, the degree of interaction of the intelligent platform, the degree of acceptance of management strategies, and the degree of popularization of the campus network indirectly promote students’ innovation ability in a weaker order. Path 1, “Intelligent level of the management team”, has a significant effect on the cultivation of students’ innovative ability, with an effect size of 51.22%.
Research on Storage Structure Design and Performance Optimization Strategy of Embedded System for Low-Capacity Storage Units
Authors: Hu Jiayang , Xiang Xiaodong
Published: October 2024

Embedded systems have attracted great attention with their unique information processing ability and human-computer interaction ability, and how to improve the processing efficiency of embedded systems for low-capacity storage units has become a key topic of current research. Based on the data storage structure characteristics and hardware devices of embedded systems, we complete the task of storage structure design for embedded systems and describe the interaction mechanism of Cache storage mode and low-capacity storage mode. Using the POSE algorithm, we optimize the execution efficiency and module energy overhead in the storage structure of the embedded system and test and optimize the embedded system. The low-capacity storage mode has fewer physical block erasures than the Cache storage mode, and the response time is 15-50 ms less. Similarly, the PEOS algorithm has advantages in the optimization of the energy overhead of the embedded system, which ranges from 0 to 0.23 × 104. This study can effectively improve the execution efficiency and energy overhead of the storage, which is of great significance for its further development.
Industrial analysis of gyro stability and precision assembly
Authors: Liang Li
Published: October 2024

Gyro is a new type of widely used micro-inertial sensor, which can realize high-precision, small-size, and anti-interference angular velocity measurement and is widely used in aerospace, platform drilling, autonomous driving, wearable devices, and cell phones. The study first analyzes the influence of the angle of control torque on the stability of the gyro and deduces the relationship between the gyro rotational inertia, spin angular velocity, feed angular velocity, and stability. Then, through the research of industrial gyro products research status, the factors affecting the precision of the gyro elaborated on the key technologies that need to be broken through in the process of gyro precision assembly and combined with the sequential stacking method to realize the gyro in the industrial close assembly. The results show that both the shape factor and scale factor are the influencing factors of gyro stability. The shape and position error of each part, as well as the coupling of the error, cause the uneven force on the motor shaft, the local stress concentration, and, therefore, local deformation, which ultimately leads to the offset of the motor shaft center, and the influence of the shape and position coupling error on the assembly precision of the gyro.
Impact of different extraction solvents and concentrations on the total phenolics content and bioactivity of the Algerian lemongrass (Cymbopogon citratus) extracts
Authors: Aouadi Abdelatif , Saoud Djamila Hamada , Rebiai Abdelkrim , Abd El-Mordy Fatma Mohamed , Laouini Salah Eddine , Achouri Abdelhak , Mustafa Yasir A. A. , Hadjadj Soumia , Mustafa Ahmed Ali
Published: October 2024

Due to its widespread range and great variety of applications, Cymbopogon citratus (DC. ex Nees) Stapf. (Poaceae) is one of the most commercially important plants in the world. In this investigation, for the proper analysis of the phenolic compounds present in plant tissues, it is essential to understand how solvent concentration and type affect the extraction process. Three different extraction solvents such as acetone, ethanol, and methanol were used at different concentrations ranging from 20% to 100% each to assess both the total phenolic (TPC) and total flavonoid content (TFC) present in each extract of C. citratus. Antibacterial activity against Gram-positive and Gram-negative bacteria, as well as two different types of fungus, was evaluated using the disc diffusion method. The stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical was used as a proxy for antioxidant capacity. The antimicrobial activity results showed that the acetone 60% extract was most effective against Pseudomonas aeruginosa (IZ = 17 mm), while the acetone 80% extract was more effective against S. cerevisiae (IZ = 18 mm). When tested against Candida albicans and Saccharomyces cerevisiae, the highest effective antifungal activity was found in the 80% acetone and 80% methanol extracts, respectively. The highest DPPH-RSA IC50 value reported was 19.22 for ethanol at 60% concentration which is correlated mainly to its greatest total flavonoid content (58.7 mg QE/100 g) in addition to (300.1 mg GAE/100 g) as a TPC followed by acetone (80%) with IC50 value 21.16. A quantitative analysis revealed that the greatest concentrations of polyphenolic compounds were found in 80% acetone (370.2 mg GAE/100 g) and 60% acetone (353.9 mg GAE/100 g), while the greatest values for total flavonoid concentration were found in 60% ethanol (58.7 mg QE/100 g) followed by 80% and 60% methanol, with 57.1 and 55.2 mg QE/100 g, respectively. In conclusion, the plant under study included a number of bioactive compounds that may be put to use in a range of unique medical and aesthetic preparations.
oung portuguese adults’ perception of mobile apps for motivation to oral health care
Authors:   Universidade de Lisboa, Faculdade de Medicina Dentária, Unidade de Investigação e Ciências Orais e Biomédicas (UICOB), Lisbon, Portugal, Costa Joana , Mendes Sónia ,   Universidade de Lisboa, Faculdade de Medicina Dentária, Unidade de Investigação e Ciências Orais e Biomédicas (UICOB), Lisbon, Portugal
Published: October 2024

Objectives: To study the perception of young Portuguese adults about using mobile applications as a complement to oral health motivation. Methods: This cross-sectional descriptive study applied an online questionnaire to Portuguese individuals between 18 and 20 years old. The questionnaire was developed based on a literature review and assessed by a panel of experts before its application. It collected information about oral hygiene behaviors and the perception of using mobile apps for oral health motivation, including opinions on important functionalities. Variables’ absolute and relative frequencies were calculated. Results: The sample included 213 participants. About 73.2% of the participants considered oral health motivational mobile apps useful, but only 6.1% indicated having already used one. The most valued functionalities were information about oral diseases (86.9%), appointment reminders (85.4%), and a toothbrushing timer (84.5%). Conclusions: Most of the participants found oral health apps useful as a complement to oral health motivation. However, only a small minority reported having used these apps before. The functionalities evidenced in this study may be helpful for the development of mobile apps since they can be more directed to the population's expectations. Apps may be another way for healthcare professionals to motivate their patients to engage in oral health selfcare.
Intermittent chemotherapy for miliary tuberculosis in children
Authors: Anadol Deniz , Kiper Nural , Göçmen Ayhan , Özçelik Uğur
Published: October 2024

Miliary tuberculosis is a severe manifestation of tuberculosis. Six children aged between two months and 10 years with the diagnosis of miliary tuberculosis were treated with intermittent antituberculous therapy for six, nine or 12 months. All the patients showed clearance of both clinical and radiological symptoms; there was no drug toxicity or resistance and no relapses were seen in the follow-up period ranging from nine months to nine years. Intermittent therapy is safe and effective in miliary tuberculosis and it may be an alternative therapy because of its minimal toxicity and lower cost.
Rh disease: intrauterine intravascular fetal blood transfusion by cordocentesis
Authors: Önderoğlu Lütfü , Öncüloğlu Cem
Published: October 2024

A total of 49 cordocenteses, including 40 intrauterine intravascular fetal blood tranasfusions, were performed in 30 pregnancies complicated by red cell isoimmunization. Transfusions were started at 19-33 weeks’ gestation and repeated up to five times, at one-to-four week intervals. The volumes of transfused blood were 20- 110 ml, hematocrits were 58-82 percent and the rate of transfusions was 1-15 ml/min. The pretransfusion fetal hemoglobins were 3.5-11.6 g/dl and the posttransfusion fetal hemoglobins were 7.5-15.6 g/dl. There were three intrauterine deaths and two neonatal deaths. The overall survival rate was 83.3 percent including all cordocenteses. The survival rate for the intrauterine transfusions was 81 percent.
Ursodeoxycholic acid therapy in children with cholestatic liver disease
Authors: Dinler Gönül , Koçak Nurten , Yüce Aysel , Gürakan Figen , Özen Hasan
Published: October 2024

The beneficial effect of ursodeoxycholic acid have been documented in adults but experience with this agent is limited in the pediatric population. The objective of this study was to evaluate ursodeoxycholic acid treatment in children with cholestatic liver disease.
Twenty-four patients with intrahepatic cholestasis (neonatal hepatitis 7, Byler disease 7, idiopathic intrahepatic cholestasis 10) whose ages ranged from 1.5 months to 15 years were treated with ursodeoxycholic acid (15-20 mg/kg/day) for 12 months. Liver biopsy was performed initially on all patients and on 17 at the end of the twelve months. The outcome was evaluated by monitoring clinical and biochemical markers of cholestasis, including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, cholesterol, total serum fasting bile acids and total and conjugated bilirubin at entry and every three months of treatment.
Pruritus was ameliorated in all patients; there was complete disappearance of itching in 16.7 percent. There were significant decreases in mean serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin and gamma-glutamyl transpeptidase. Liver biopsy specimens showed a significant improvement in the cholestasis but not in fibrosis. No adverse effects of therapy were noted.
The improvements in the clinical and biochemical parameters and tolerability of the drug suggest that ursodeoxycholic acid is a safe and effective treatment in children with intrahepatic cholestasis.
Phytochemical Screening, Isolation and Estimation of bioactive lupeol, In vitro and in silico neuroprotective effect of phytoconstituents from Karnasphota: Cardiospermum halicacabum Linn. roots
Authors: Topiya Hiral R , Pandya Devang J
Published: October 2024

The importance of herbals in neurodegenerative disorders lies in their ability to offer multifaceted therapeutic benefits, including neuroprotection, anti-inflammation, antioxidant effects and cognitive enhancement. Karnasphota is a memory enhancer as per Ayurveda and is described as Medhya. This claim is evaluated scientifically for the scope of treating neurodegenerative disorders. Proximate analysis and phytochemical profiling were performed after solvent extraction of the powdered root of C. halicacabum L. An in vitro DPPH antioxidant assay, acetylcholinesterase and tyrosinase enzyme inhibition effect was carried out to identify the capability of root extract as a neuro-shielding agent. The total content of bioactive triterpenoid lupeol was estimated by HPTLC followed by its isolation. The total lupeol content as a bioactive marker found was 6.400 µg. The plant root phytoconstituents are potent antioxidants with IC50 89.08 µg, comparable to the positive control. The potency of the phytoconstituents was demonstrated by in vitro inhibition of acetylcholinesterase and tyrosinase enzymes as compared to Physostigmine and Pregabalin respectively by HPLC that shows optimum potency compared to standards. An in-silico study against AChE evaluated the potential of the identified phytoconstituents. An in-silico study revealed most phytoconstituents are promising anti-Alzheimer's leads compared to Donepezil, an acetylcholinesterase inhibitor.
Molecular Docking and ADMET Profiling of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin from Dalbergia sissoo: In Silico Prediction in Antidiabetic Potential
Authors: Maya  , Yadav Raj KS
Published: October 2024

In the quest for efficient treatment for diabetes mellitus (DM), human dipeptidyl peptidase-IV (DPP-IV) inhibitors have shown potential oral antidiabetic medications. Despite their potential, many existing medications are associated with adverse effects, highlighting the need for novel and safer alternatives. Type 2 diabetes mellitus (T2DM) treatment often relies on incretin hormones (GLP-1 and GIP), which play crucial roles in metabolism, such as enhancing secretion of insulin. However, the DPP-IV enzyme deactivates these incretins, necessitating the identification of effective DPP-IV inhibitors as potential antidiabetic agents. Although synthetic inhibitors like vildagliptin, sitagliptin, and saxagliptin are available, they can have adverse effects. Conversely, several natural plants and products inhibit the DPP-IV enzyme, offering safer and effective alternatives for diabetes treatment. This research uses a multifaceted strategy involving pharmacokinetic/toxicity assessment and in-silico Molecular Docking to explore the potential of phytochemicals from Dalbergia sissoo (D. sissoo) as DPP-IV inhibitors with antidiabetic properties. An investigation of 21 specific phytoconstituents from D. sissoo using molecular docking shows that six of them have a higher binding affinity (ΔG ≥ -7.3 kcal/mol) and significantly lower inhibition constants (Ki ≤ 3.17 µM) compared to the well-established drug Vildagliptin (ΔG = -7.3 kcal/mol, Ki = 4.45 µM). Among the top-performing compounds, Sissotrin, Isocaviudin, Tectoridin, Caviunin 7-O-glucoside, Biochanin A, 6, 7-Dimethoxy-4-phenylcoumarin, Tectorigenin, Nordalbergin, 5-Hydroxy-6,7,4'-trimethoxyisoflavone, and Dalbergin, additional study utilizing pharmacophore/ADMET profiling validates their drug-like characteristics. These phytochemicals follow Lipinski's Rule of Five, showing desirable drug qualities and having high oral availability. The results indicate that phytochemicals from D.sissoo, especially the specific compounds identified, show potential as DPP-IV inhibitors. These compounds show strong in-silico properties and deserve more experimental testing, suggesting they could be safer and more efficient options for developing new antidiabetic drugs.
Novel approaches in Paediatric Drug Delivery System
Authors: Dey Paramita , Bairagi Saheli , Mondal Sandip Kumar
Published: October 2024

The development of medication delivery technology has led to an increase in the popularity of pediatric formulations. However, there is absence of secure and efficient drug delivery mechanism for pediatric patients. It is crucial to design and create a novel and suitable delivery system to guarantee precise and reliable medication administration to pediatric patients, as their pharmacokinetics and pathophysiologic profiles differ from those of adults. Under this heading, discussion will be carried out in order to increase stability; new medication delivery techniques and technology are being developed to enhance the stability, toxicity, flexibility, moreover secure aspects of pediatric oral formulations. Specifically, issues with patient acceptability and manufacturability are discussed in this section, and innovative medication delivery methods are examined to address current issues.
Influence of Kunjal Kriya on Respiratory Physiology - A Comprehensive Review
Authors: Sheela Joice P P , Vilva Vaithiyanadane
Published: October 2024

The ancient yogic cleaning technique known as Kunjal Kriya has garnered attention for its potential benefits to respiratory health. This comprehensive review examines Kunjal Kriya's physiological effects, focusing on its ability to enhance lung function, facilitate mucous clearance, and promote overall respiratory wellness. By integrating clinical evidence, current research findings, and traditional practices, this review aims to offer an in-depth understanding of Kunjal Kriya’s impact on respiratory health. The review begins with an exploration of Kunjal Kriya's historical origins and its relation to other yogic practices. It then delves into the physiological mechanisms through which Kunjal Kriya influences respiratory health, including the strengthening of respiratory muscles, increased oxygen intake, and enhanced lung capacity. These benefits are thought to improve tissue oxygenation and respiratory efficiency, potentially aiding those with respiratory conditions. Additionally, Kunjal Kriya’s role in facilitating mucus clearance from the respiratory system is highlighted. By inducing the gag reflex and promoting the expulsion of mucus from the throat and upper airway, Kunjal Kriya contributes to better respiratory hygiene and reduced incidence of infections, which is crucial for conditions characterized by mucus buildup. Beyond its physiological benefits, Kunjal Kriya supports general respiratory wellness through its emphasis on deep breathing and focused awareness. These elements foster mind-body integration, relaxation, and stress reduction, which may enhance overall respiratory health and complement conventional treatments. The review also discusses clinical evidence supporting Kunjal Kriya’s efficacy in respiratory management. While some studies show promising results, further research, including randomized controlled trials, is needed to validate and explore Kunjal Kriya’s potential as an adjunct therapy for various respiratory conditions. In conclusion, Kunjal Kriya offers a holistic approach to respiratory health by promoting overall wellbeing, facilitating mucous clearance, and improving physiological function. Further exploration of Kunjal Kriya’s effects could provide valuable insights into its role in respiratory health management.
Blood-borne biomarkers: CT-DNA ushers in a new era of cancer detection
Authors: Palve Sanket , Bhardwaj Yash , Dusane Jayesh , Wankhade Pavankumar
Published: October 2024

Circulating tumor DNA, also called ctDNA, is gaining popularity as a valuable tool for monitoring cancer through non-invasive methods. This review seeks to offer a comprehensive overview of ctDNA, encompassing its biological basis, detection technologies, clinical applications, and challenges. ctDNA originates from tumor cells that undergo apoptosis and necrosis, and contain cancer-specific genomic and epigenomic alterations. Sensitive methodologies leveraging sequencing, digital PCR, and enzymatic assays enable the analysis of mutations, methylation patterns, and copy number variations. ctDNA facilitates early diagnosis, minimal residual disease tracking, therapeutic monitoring, detection of emergent resistance mutations, and prognostic estimates across diverse cancer types. Ongoing trials aim to validate ctDNA's clinical utility and determine whether ctDNA-guided early interventions enhance outcomes. Detection using ctDNA analysis faces some challenges, including specificity, sensitivity, and result interpretation. Research is needed towards advancing the detection technology, development of standards, and establishing clinical validity. Overall, the analysis of plasma ctDNA provides a powerful and minimally invasive avenue for understanding tumor dynamics in real-time to enable personalized therapeutic approaches, monitoring, and potentially early cancer detection.
STUDI HUKUM TANGGUNG JAWAB DROPSHIPPER DAN DISTRIBUTOR PADA TRANSAKSI ONLINE
Authors: Aisyah Nada
Published: October 2024

This paper aims to find out how the legal review of the Dropshipper's responsibility with the distributor. In online-based business transactions, the parties still use the rules in the Civil Code as the rules in making agreements. Another rule used in e-commerce transactions is Law No. 11 of 2008 concerning Information and Electronic Transactions which has been amended by Law No. 19 of 2016 (hereinafter referred to as the ITE Law). In connection with this, this thesis raises three problems, namely first, how is the legal regulation related to agreements in online-based business transactions carried out by dropshippers with distributors, second, how does the existence of a business relationship between dropshippers and distributors affect online-based business transactions, and third, what is the form of legal protection for the division of responsibility between dropshippers and distributors in online-based business transactions
توظيف العقوبات الاقتصادية في العلاقات الدولية بعد الحرب الباردة: دراسة نماذج مختارة
Authors: م.د هبة نصير عبدالرزاق
Published: October 2024

في عصرنا الحالي يعد الإقتصاد الجزء الأکبر والأهم للقوة الدولية لأي دولة في المجتمع الدولي ، لدرجة أصبح معها ضعف الدولة إقتصادياً بمثابة عجز لا يمکن أن يغطيه نفوذها السياسي أو العسکري، وتحول إلى وسيلة من وسائل الحرب تفوق في هزيمتها الوسائل العسکرية ومع تطور العلاقات الدولية وتراجع فکرة إستعمال القوة في تسوية النزاعات الدولية . وظهور وسائل سلمية لحلها ، بدأت العقوبات الإقتصادية تأخذ شکلاً أکثر تطوراً وأصبحت تطبق بشکل مستقل کما أصبحت هدفاً في حد ذاته ولم تعد إجراءاً تکميلياً ملحقاً بالعمليات العسکرية .
Real-Time Aerodynamic Load Estimation for Hypersonics via Strain-Based Inverse Maps
Authors: Pham Julie V. , Ghattas Omar , Clemens Noel T. , Willcox Karen E.
Published: October 2024

This work develops an efficient real-time inverse formulation for inferring the aerodynamic surface pressures on a hypersonic vehicle from sparse measurements of the structural strain. The approach aims to provide real-time estimates of the aerodynamic loads acting on the vehicle for ground and flight testing, as well as guidance, navigation, and control applications. Specifically, the approach targets hypersonic flight conditions where direct measurement of the surface pressures is challenging due to the harsh aerothermal environment. For problems employing a linear elastic structural model, the inference problem can be posed as a least-squares problem with a linear constraint arising from a finite element discretization of the governing elasticity partial differential equation. Due to the linearity of the problem, an explicit solution is given by the normal equations. Precomputation of the resulting inverse map enables rapid evaluation of the surface pressure and corresponding integrated quantities, such as the force and moment coefficients. The inverse approach additionally allows for uncertainty quantification, providing insights for theoretical recoverability and robustness to sensor noise. Numerical studies demonstrate the estimator performance for reconstructing the surface pressure field, as well as the force and moment coefficients, for the Initial Concept 3.X (IC3X) conceptual hypersonic vehicle.
Study of the magnetic field effect on partial discharges characteristics
Authors:   Omsk State Technical University, Polyakov D. A. , Kholmov M. A. ,   Omsk State Technical University, Nikitin K. I. ,   Omsk State Technical University
Published: October 2024

The paper is devoted to the study of the dependences of the characteristics of partial discharges on magnetic induction. The design of the experimental setup has been developed. It allows applying both high voltage and current comparable to the operating one. The setup includes a high voltage source (dielectric tester), a current flow circuit, a high voltage current transformer and a sample of XLPE insulated cable. The operation of the electrical circuit of the experimental setup is simulated using software. The modeling has shown that if the operational electrical strength of the current transformer insulation is present, the high-voltage potential cannot contact the current flow circuit. After this, modeling of the magnetic field inside the insulating layer is carried out. Based on the developed design, an experimental setup is created. To record partial discharges, an artificial defect is created in a cable sample. The results of magnetic field modeling made it possible to estimate the magnetic induction in the field of an artificial cable defect. Next, experimental studies are carried out to assess the influence of the magnetic field of the cable core current on the characteristics of partial discharges. The measurement results have showed a decrease in the average apparent charge of partial discharges and partial discharge power with increasing current. In addition, waveforms are compared, but no significant differences are found. The magnetic field of the current may influence the PD performance in the long term due to its possible influence on the direction of growth of the electrical tree structure.
Qualitative modification of geometrically oriented methods for constructing spatial curves in C3D FairCurveModeler
Authors:   LLC «C3D Labs», Mufteev V. G. , Ziganshina F. T. ,   Ufa State Petroleum Technological University, Gumerov V. I. ,   Ufa State Petroleum Technological University, Nabiev R. I. ,   Ufa State Petroleum Technological University, Efimova G. M. ,   Ufa State Petroleum Technological University
Published: October 2024

The article provides a detailed algorithm for improving the C3D FairCurveModeler commands for constructing a class F spatial curve with approximation by a rational cubic spline Bezier curve (NURBzS-curve) and with approximation by a highdegree B-spline curve. The improvement is achieved by optimizing the structure of the Hermite spatial Geometric Determinant when defining it on a spatial virtual curve (V-curve) created on a set of double-tap conical curves. The structure of the Hermite Geometric Determinant is improved by changing the direction of the tangents, taking into account the spatial directions of the tangents at the end points of the conic segments at the step of constructing the set of double-tap conical curves. To demonstrate the modified method, the work shows 1) Improving the quality of a conical spiral modeled by the regular _Helix command of CAD systems ZWCAD, BricsCAD, AutoCAD by using the C3D FairCurveModeler command for creating a NURBzS-curve. 2) Construction of a B-spline curve of the 8th degree on the points of a conical spiral by the C3D FairCurveModeler command and comparison with similar constructions in the CAD systems 'Rhino Ceros D', 'Alias Design Studio', NX which declare the construction of high quality curves (class A).
Determining the nonlinear damping function using experiments
Authors:   Omsk State Technical University, Kalashnikov B. A. , Bokhan V. V. ,   Omsk State Technical University, Penkov K. V. ,   Omsk State Technical University
Published: October 2024

In this article, the coefficients of the nonlinear damping function of a mechanical system with one translational degree of freedom are determined from an experimentally obtained oscillogram of free vibrations. The function is modeled using three types of damping: coulomb damping, linear viscous, and nonlinear viscous damping. Numerical values of the damping coefficients are identified. The characteristic of the dissipative force as a function of displacement is obtained, and is used to find the amount of energy dissipated over a time period. An equivalent relative damping ratio is approximated using the energy balance method and then used to perform numerical integration of the equation of motion. A satisfactory match of the envelope curve and the phase of the vibrational process is demonstrated by comparing the calculated oscillogram to the experimental one. The damping function parameters can be further refined by approximating the experimental amplitudes. The obtained value of the relative damping coefficient can be used to solve nonlinear problems in the area of dynamics of weakly damped systems.
Modeling the boundaries of the working space of a planar three-link manipulator
Authors:   Omsk State Technical University, Sheveleva T. A. , Lyashkov A. A. ,   Omsk State Technical University
Published: October 2024

A study of the boundaries of the working space of a three-link planar manipulator, specified by analytical equations, is carried out. A new geometric interpretation of these samples is proposed. On its basis, it is established that outer space consists of two-parameter volumes of eccentric and concentric circles. When transforming such environments into four-dimensional space, two types of hypersurfaces are obtained, which represent a geometric model of the manipulator's workspace. The discriminants of these hypersurfaces on the hyperplane are two two-dimensional surfaces. Both an analytical description of these surfaces and their computer models are obtained. As a result, it is established that the boundaries of the working space on the plane of the mechanism are the discriminants of such surfaces. To confirm the reliability of the results obtained, as an example, an inverse kinematics problem is solved on discriminant surfaces — the values of generalized coordinates at the boundary points of the manipulator’s workspace are determined for their given Cartesian coordinates.
The analysis of losses in protected and non-insulated wires in stationary modes, taking into account weather conditions
Authors:   Omsk State Technical University, Petrova E. V. , Girshin S. S. ,   Omsk State Technical University, Krivolapov V. A. ,   Omsk State Technical University, Khatsevskiy K. V. ,   Omsk State Technical University, Goryunov V. N. ,   Omsk State Technical University, Trotsenko V. M. ,   Omsk State Technical University
Published: October 2024

In overhead lines of power supply systems at voltages of 6–110 kV, the use of protected wires is becoming increasingly popular, which have a number of advantages over traditional non-insulated aluminum wires. On the other hand, the presence of insulation requires the development of more complex mathematical models to adequately describe their behavior and study the characteristics of new wires during operation. The results of using the developed mathematical models and calculation programs for comparative analysis of protected and non-insulated wires under conditions of changing load currents and weather conditions are presented. The dependences of temperature and loss of active power on insulation thickness are investigated. It is shown that the presence of insulation allows, under certain conditions, to reduce temperature and losses compared to wires without insulation, all other things being equal. The results obtained can be used to increase the capacity and reliability of power transmission lines.
Pathological laughter as an initial presentation of bilateral internal carotid artery agenesis
Authors: Eapen Kurian C. , Selvaganesan Selvakumar , Jasper Anitha , Prabhakar A. T.
Published: October 2024

In this case report, we describe a rare case of bilateral internal carotid artery (ICA) agenesis, with a peculiar symptom of inappropriate laughter preceding neurological manifestations. The patient’s atypical presentation included episodes of premature laughter, preceding symptoms of headache, numbness, and jerky movements in the upper limbs. Imaging studies revealed multiple acute infarcts in the anterior cerebral circulation territories bilaterally, along with non-visualization of bilateral ICAs. The absence of bilateral carotid canals further confirmed the diagnosis. Hypertrophied posterior communicating arteries and collaterals from the left external carotid artery were identified, contributing to compensatory circulation. The primary focus of treatment was on the conservative management of acute stroke symptoms, including regular monitoring to identify potential complications, especially the development of intracranial aneurysms. This case highlights the importance of multi-disciplinary collaborative efforts among radiologists, neurologists, and vascular surgeons for accurate diagnosis and effective treatment of rare vascular anomalies.