bluuebunny/crossref_metadata_2025 huggingface dataset:
A retrospective multicenter cohort study of the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19
Authors: Jonmarker Sandra , Litorell Jacob , Alarcon Felix , Al-Abani Kais , Björkman Sofia , Farm Maria , Grip Jonathan , Söderberg Mårten , Hollenberg Jacob , Wahlin Rebecka Rubenson , Kander Thomas , Rimling Liivi , Mårtensson Johan , Joelsson-Alm Eva , Dahlberg Martin , Cronhjort Maria
Published: October 2023

Background

Patients with critical COVID-19 have a high risk of thromboembolism, but intensified thromboprophylaxis has not been proven beneficial. The activity of low-molecular-weight heparins can be monitored by measuring anti-Factor Xa. We aimed to study the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.

Method

This retrospective cohort study included adult patients with critical COVID-19 admitted to an intensive care unit at three Swedish hospitals between March 2020 and May 2021 with at least one valid peak and/or trough anti-Factor Xa value. Within the peak and trough categories, patients’ minimum, median, and maximum values were determined. Logistic regressions with splines were used to assess associations.

Results

In total, 408 patients had at least one valid peak and/or trough anti-Factor Xa measurement, resulting in 153 patients with peak values and 300 patients with trough values. Lower peak values were associated with thromboembolism for patients’ minimum (p = 0.01), median (p = 0.005) and maximum (p = 0.001) values. No association was seen between peak values and death or bleeding. Higher trough values were associated with death for median (p = 0.03) and maximum (p = 0.002) values and with both bleeding (p = 0.01) and major bleeding (p = 0.02) for maximum values, but there were no associations with thromboembolism.

Conclusions

Measuring anti-Factor Xa activity may be relevant for administrating low-molecular-weight heparin to patients with critical COVID-19. Lower peak values were associated with an increased risk of thromboembolism, and higher trough values were associated with an increased risk of death and bleeding. Prospective studies are needed to confirm the results.

Trial registration

The study was retrospectively registered at Clinicaltrials.gov, NCT05256524, February 24, 2022.
Early implementation learnings on acceptability and feasibility of “V”: a multi-level PrEP intervention designed with and for adolescent girls and young women in Zimbabwe
Authors: Sisimayi Thenjiwe , Nhamo Definate , Chatora Kumbirai , Chapwanya Gwendoline , Mawoyo Tinovonga , Ncube Getrude , Bruns Cal , Harris Emily L. , Shelley Katharine D.
Published: October 2023

Introduction

Adolescent girls and young women (AGYW) remain disproportionately affected by HIV in Zimbabwe. Several HIV prevention options are available, including oral tenofovir-based pre‐exposure prophylaxis (PrEP), however AGYW face unique barriers to PrEP uptake and continuation and novel approaches are therefore needed to empower AGYW to use PrEP. The objective of this study was to characterize early learnings from implementing a multi-level intervention consisting of fashionable branding (including a “V Starter Kit”), service integration, and peer education and support throughout a young woman's journey using oral PrEP across four phases of implementation, from creating demand, preparing for PrEP, initiation of PrEP, and adherence to PrEP.

Methods

A mixed methods implementation research study was undertaken, including site observations and interviews to explore the acceptability of “V” and its relevance to target users, as well as the feasibility of integrating “V” with existing service delivery models. Interviews (n = 46) were conducted with healthcare workers, Brand Ambassadors, and young women purposively sampled from four implementation sites. Interview data was analyzed thematically using the framework method for qualitative data management and analysis. Project budgets and invoices were used to compile unit cost and procurement data for all “V” materials.

Results

“V” was acceptable to providers and young women due to attractive branding coupled with factual and thought-provoking messaging, establishing “a girl code” for discussing PrEP, and addressing a gap in communications materials. “V” was also feasible to integrate into routine service provision and outreach, alongside other services targeting AGYW. Cost for the “V” branded materials ranked most essential—FAQ insert, pill case, makeup bag, reminder sticker—were $7.61 per AGYW initiated on PrEP.

Conclusion

“V” is a novel approach that is an acceptable and feasible multi-level intervention to improve PrEP access, uptake, and continuation among AGYW, which works through empowering AGYW to take control of their HIV prevention needs. In considering “V” for scale up in Zimbabwe, higher volume procurement and a customized lighter package of “V” materials, while still retaining V’s core approach, should be explored.
Utilization of innovative medical technologies in German inpatient care: does evidence matter?
Authors: Eckhardt Helene , Felgner Susanne , Dreger Marie , Fuchs Sabine , Ermann Hanna , Rödiger Hendrikje , Rombey Tanja , Busse Reinhard , Henschke Cornelia , Panteli Dimitra
Published: October 2023

Background

The reimbursement of new technologies in inpatient care is not always linked to a requirement for evidence-based evaluation of patient benefit. In Germany, every new technology approved for market was until recently eligible for reimbursement in inpatient care unless explicitly excluded. The aim of this work was (1) to investigate the type of evidence that was available at the time of introduction of 25 innovative technologies and how this evidence evolved over time, and (2) to explore the relationship between clinical evidence and utilization for these technologies in German inpatient care.

Methods

This study combined different methods. A systematic search for evidence published between 2003 and 2017 was conducted in four bibliographic databases, clinical trial registries, resources for clinical guidelines, and health technology assessment—databases. Information was also collected on funding mechanisms and safety notices. Utilization was measured by hospital procedures captured in claims data. The body of evidence, funding and safety notices per technology were analyzed descriptively. The relationship between utilization and evidence was explored empirically using a multilevel regression analysis.

Results

The number of included publications per technology ranges from two to 498. For all technologies, non-comparative studies form the bulk of the evidence. The number of randomized controlled clinical trials per technology ranges from zero to 19. Some technologies were utilized for several years without an adequate evidence base. A relationship between evidence and utilization could be shown for several but not all technologies.

Conclusions

This study reveals a mixed picture regarding the evidence available for new technologies, and the relationship between the development of evidence and the use of technologies over time. Although the influence of funding and safety notices requires further investigation, these results re-emphasize the need for strengthening market approval standards and HTA pathways as well as approaches such as coverage with evidence development.
The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
Authors: Gélabert Caroline , Papoutsoglou Panagiotis , Golán Irene , Ahlström Eric , Ameur Adam , Heldin Carl-Henrik , Caja Laia , Moustakas Aristidis
Published: October 2023

Background

Long non-coding RNAs (lncRNAs) regulate cellular processes by interacting with RNAs or proteins. Transforming growth factor β (TGFβ) signaling via Smad proteins regulates gene networks that control diverse biological processes, including cancer cell migration. LncRNAs have emerged as TGFβ targets, yet, their mechanism of action and biological role in cancer remain poorly understood.

Methods

Whole-genome transcriptomics identified lncRNA genes regulated by TGFβ. Protein kinase inhibitors and RNA-silencing, in combination with cDNA cloning, provided loss- and gain-of-function analyses. Cancer cell-based assays coupled to RNA-immunoprecipitation, chromatin isolation by RNA purification and protein screening sought mechanistic evidence. Functional validation of TGFβ-regulated lncRNAs was based on new transcriptomics and by combining RNAscope with immunohistochemical analysis in tumor tissue.

Results

Transcriptomics of TGFβ signaling responses revealed down-regulation of the predominantly cytoplasmic long intergenic non-protein coding RNA 707 (LINC00707). Expression of LINC00707 required Smad and mitogen-activated protein kinase inputs. By limiting the binding of Krüppel-like factor 6 to the LINC00707 promoter, TGFβ led to LINC00707 repression. Functionally, LINC00707 suppressed cancer cell invasion, as well as key fibrogenic and pro-mesenchymal responses to TGFβ, as also attested by RNA-sequencing analysis. LINC00707 also suppressed Smad-dependent signaling. Mechanistically, LINC00707 interacted with and retained Smad proteins in the cytoplasm. Upon TGFβ stimulation, LINC00707 dissociated from the Smad complex, which allowed Smad accumulation in the nucleus. In vivo, LINC00707 expression was negatively correlated with Smad2 activation in tumor tissues.

Conclusions

LINC00707 interacts with Smad proteins and limits the output of TGFβ signaling, which decreases LINC00707 expression, thus favoring cancer cell invasion.
Preoperative fluorescence in situ hybridization analysis as a predictor of tumor recurrence in patients with non-muscle invasive bladder cancer: a bi-institutional study
Authors: Zheng Junjiong , Lu Sihong , Huang Yi , Chen Xu , Zhang Jie , Yao Yuhui , Cai Jinhua , Wu Jieying , Kong Jianqiu , Lin Tianxin
Published: October 2023

Background

Non-muscle invasive bladder cancer (NMIBC) is known for its elevated recurrence rate, necessitating an enhancement in the current risk stratification for recurrence. The urine-based fluorescence in situ hybridization (FISH) assay has emerged as a noninvasive auxiliary tool for detecting bladder cancer. The aim of this study was to explore the potential relationship between the preoperative FISH assay and recurrence, and to develop a FISH-clinical nomogram for predicting the recurrence-free survival (RFS) in NMIBC patients.

Methods

In total, 332 eligible patients were enrolled from two hospitals. The SYSMH cohort was randomly assigned to the training set (n = 168) and the validation set I (n = 72) at a ratio of 7:3, while the SYSUTH cohort was allocated to the validation set II (n = 92). The correlation between the preoperative FISH assay and recurrence was determined through the Cox regression analysis. The least absolute shrinkage and selection operator (LASSO) Cox regression algorithm was used for model construction. The performance of the model was assessed by its discrimination, calibration, and clinical usefulness.

Results

We uncovered that chromosome 7 aneuploidy, p16 locus loss, number of the positive FISH sites, and the FISH test result were significantly associated with tumor recurrence. Then, a FISH-clinical nomogram incorporating the FISH test result, T stage, associated CIS, tumor grade, and tumor status was developed. It showed favorable calibration and discrimination with a C-index of 0.683 (95%CI, 0.611–0.756) in the training set, which was confirmed in the validation set I and validation set II with C-indexes of 0.665 (95%CI, 0.565–0.765) and 0.778 (95%CI, 0.665–0.891), respectively. Decision curve analysis revealed the clinical usefulness of the nomogram. Moreover, our proposed nomogram significantly outperformed the guideline-recommended EORTC and CUETO scoring models.

Conclusion

Our study confirmed the prognostic value of the preoperative FISH assay and proposed a FISH-clinical nomogram to predict RFS in NMIBC patients. Our nomogram can serve as a more precise tool for recurrence risk stratification, which may optimize disease management in bladder cancer and improve patient prognosis.
Use of routine healthcare data in randomised implementation trials: a methodological mixed-methods systematic review
Authors: Xie Charis Xuan , Sun Lixin , Ingram Elizabeth , De Simoni Anna , Eldridge Sandra , Pinnock Hilary , Relton Clare
Published: October 2023

Background

Routine data are increasingly used in randomised controlled trials evaluating healthcare interventions. They can aid participant identification, outcome assessment, and intervention delivery. Randomised implementation trials evaluate the effect of implementation strategies on implementation outcomes. Implementation strategies, such as reminders, are used to increase the uptake of evidence-based interventions into practice, while implementation outcomes, such as adoption, are key measures of the implementation process. The use of routine data in effectiveness trials has been explored; however, there are no reviews on implementation trials. We therefore aimed to describe how routine data have been used in randomised implementation trials and the design characteristics of these trials.

Methods

We searched MEDLINE (Ovid) and Cochrane Central Register of Controlled Trials from Jan 2000 to Dec 2021 and manually searched protocols from trial registers. We included implementation trials and type II and type III hybrid effectiveness-implementation trials conducted using routine data. We extracted quantitative and qualitative data and narratively synthesised findings.

Results

From 4206 titles, we included 80 trials, of which 22.5% targeted implementation of evidence-based clinical guidelines. Multicomponent implementation strategies were more commonly evaluated (70.0%) than single strategies. Most trials assessed adoption as the primary outcome (65.0%). The majority of trials extracted data from electronic health records (EHRs) (62.5%), and 91.3% used routine data for outcome ascertainment. Reported reasons for using routine data were increasing efficiency, assessing outcomes, reducing research burden, improving quality of care, identifying study samples, confirming findings, and assessing representativeness. Data quality, the EHR system, research governance, and external factors such as government policy could act either as facilitators or barriers.

Conclusions

Adherence to guidance on designing and reporting implementation studies, and specifically to harmonise the language used in describing implementation strategies and implementation outcomes, would aid identification of studies and data extraction. Routine healthcare data are widely used for participant identification, outcome assessment and intervention delivery. Researchers should familiarise themselves with the barriers and facilitators to using routine data, and efforts could be made to improve data quality to overcome some of the barriers.

Registration

PROSPERO CRD42022292321.
The antidepressant effect of intermittent theta burst stimulation (iTBS): study protocol for a randomized double-blind sham-controlled trial
Authors: Ørbo Marte Christine , Grønli Ole K. , Larsen Camilla , Vangberg Torgil R. , Friborg Oddgeir , Turi Zsolt , Mittner Matthias , Csifcsak Gabor , Aslaksen Per M.
Published: October 2023

Background

Intermittent theta burst stimulation (iTBS) when applied over the left dorsolateral prefrontal cortex (DLPFC) has been shown to be equally effective and safe to treat depression compared to traditional repetitive transcranial magnetic stimulation (rTMS) paradigms. This protocol describes a funded single-centre, double-blind, randomized placebo-controlled, clinical trial to investigate the antidepressive effects of iTBS and factors associated with an antidepressive response.

Methods

In this trial, outpatients (N = 96, aged 22–65 years) meeting the diagnostic criteria for at least moderate depression (Montgomery and Aasberg Depression Rating Scale score ≥ 20) will be enrolled prospectively and receive ten, once-a-day sessions of either active iTBS or sham iTBS to the left DLPFC, localized via a neuronavigation system. Participants may have any degree of treatment resistance. Prior to stimulation, participants will undergo a thorough safety screening and a brief diagnostic assessment, genetic analysis of brain-derived neurotropic factor, 5-HTTLPR and 5-HT1A, and cerebral MRI assessments. A selection of neuropsychological tests and questionnaires will be administered prior to stimulation and after ten stimulations. An additional follow-up will be conducted 4 weeks after the last stimulation. The first participant was enrolled on June 4, 2022. Study completion will be in December 2027. The project is approved by the Regional Ethical Committee of Medicine and Health Sciences, Northern Norway, project number 228765. The trial will be conducted according to Good Clinical Practice and published safety guidelines on rTMS treatment.

Discussion

The aims of the present trial are to investigate the antidepressive effect of a 10-session iTBS protocol on moderately depressed outpatients and to explore the factors that can explain the reduction in depressive symptoms after iTBS but also a poorer response to the treatment. In separate, but related work packages, the trial will assess how clinical, cognitive, brain imaging and genetic measures at baseline relate to the variability in the antidepressive effects of iTBS.

Trial registration

ClinicalTrials.gov NCT05516095. Retrospectively registered on August 25, 2022.
Dual tracer navigation for lymph node dissection in laparoscopic radical gastrectomy (DANCE trial): a protocol for a prospective, randomized clinical trial
Authors: Lu Yanjun , Ai Shichao , Song Peng , Sun Yan , Shen Xiaofei , Sun Feng , Hu Qiongyuan , Li Zhiyan , Wang Meng , Lu Xiaofeng , Guan Wenxian , Liu Song
Published: October 2023

Background

Lymph node (LN) metastasis is the most common metastasis route in gastric cancer. Extensive dissection of LNs can significantly improve the prognosis of patients with gastric cancer. Recently, multiple clinical studies have demonstrated that either indocyanine green (ICG) or carbon nanoparticles (CNs) can assist to promote the dissection of LNs during laparoscopic radical gastrectomy. Considering the pros and cons of the two tracers, this study proposed a novel method of dual tracer (ICG combined with CNs) for lymphatic tracing in laparoscopic gastric cancer surgery.

Methods

This trial is a prospective, randomized controlled trial (RCT) with an estimation of 516 participants that randomize into 4 groups (1:1:1:1), namely control group, ICG group, CNs group, and dual tracer group. The primary outcome is the number of dissected LNs. The secondary outcomes include positive rate, false positive rate, negative rate, false negative rate, number of metastatic LNs, relationship between LN metastasis and tracer stained, operation duration, blood loss, incision length, morbidity and mortality rate, 3-year DFS (disease free survival), PFS (progression-free survival), and OS (overall survival).

Discussion

This study will investigate the efficacy and safety of a novel strategy using dual tracers for laparoscopic gastrectomy. The protocol has been approved by the Ethics Committee of Nanjing Drum Tower Hospital (2021-361-02). The trial findings will be published in peer-reviewed journals.

Trial registration

Chinese Clinical Trial Registry (ChiCTR2100051309). Registered 18 September 2021, https://www.chictr.org.cn/showproj.html?proj=133764.
Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis
Authors: Zhang Fen , Cheng Ting , Zhang Sheng-Xiao
Published: October 2023

Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic synovitis and bone destruction. Proinflammatory cytokines activate pathways of immune-mediated inflammation, which aggravates RA. The mechanistic target of rapamycin (mTOR) signaling pathway associated with RA connects immune and metabolic signals, which regulates immune cell proliferation and differentiation, macrophage polarization and migration, antigen presentation, and synovial cell activation. Therefore, therapy strategies targeting mTOR have become an important direction of current RA treatment research. In the current review, we summarize the biological functions of mTOR, its regulatory effects on inflammation, and the curative effects of mTOR inhibitors in RA, thus providing references for the development of RA therapeutic targets and new drugs.
Stress, depression, and risk of dementia – a cohort study in the total population between 18 and 65 years old in Region Stockholm
Authors: Wallensten Johanna , Ljunggren Gunnar , Nager Anna , Wachtler Caroline , Bogdanovic Nenad , Petrovic Predrag , Carlsson Axel C.
Published: October 2023

Background

Chronic stress and depression are potential risk factors for mild cognitive impairment and dementia, including Alzheimer disease. The aim was to investigate whether any such risk is additive.

Methods

Cohort study including 1 362 548 people (665 997 women, 696 551 men) with records in the Region Stockholm administrative healthcare database (VAL).

Exposure was a recorded ICD-10 diagnosis of chronic stress, depression, or both, recorded in 2012 or 2013. Outcome was a diagnosis of Alzheimer disease, other dementia, or mild cognitive impairment recorded from 2014 through 2022. Odds ratios with 99% confidence intervals (CI) adjusted for age, sex, neighborhood socioeconomic status, diabetes, and cardiovascular disorders were calculated.

Results

During the exposure period, 4 346 patients were diagnosed with chronic stress, 40 101 with depression, and 1 898 with both. The average age at baseline was around 40 years in all groups. In the fully adjusted model, the odds ratio of Alzheimer disease was 2.45 (99% CI 1.22–4.91) in patients with chronic stress, 2.32 (99% CI 1.85–2.90) in patients with depression, and 4.00 (99% CI 1.67–9.58) in patients with chronic stress and depression. The odds ratio of mild cognitive impairment was 1.87 (99% CI 1.20–2.91) in patients with chronic stress, 2.85 (99% CI 2.53–3.22) in patients with depression, and 3.87 (99% CI 2.39–6.27) in patients with both. When other dementia was analyzed, the odds ratio was significant only in patients with depression, 2.39 (99% CI 1.92–2.96).

Conclusions

Documented chronic stress increased the risk of mild cognitive impairment and Alzheimer disease. The same was seen with depression. The novel finding is the potential additive effect of chronic stress to depression, on risk of MCI and AD.
Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response
Authors: Li Dongli , Ou Qingjian , Shen Qi , Lu Michael Mingze , Xu Jing-Ying , Jin Caixia , Gao Furong , Wang Juan , Zhang Jingfa , Zhang Jieping , Li Jiao , Lu Lixia , Xu Guo-Tong , Tian Haibin
Published: October 2023

Background

T helper 2 (Th2) cells are thought to play critical roles in allergic conjunctivitis (AC). They release inflammatory cytokines to promote an allergic response in AC. Due to individual heterogeneity and long-term chronic management, current therapies do not always effectively control AC. Mesenchymal stem cells (MSCs) have been shown to be effective in treating allergy-related disorders, but it is unclear how exactly the Th2-mediated allergic response is attenuated. This study aims to elucidate the therapeutic effect and mechanism of the human umbilical cord MSCs (hUCMSCs) in a mouse model of experimental AC (EAC).

Methods

A mouse EAC model was established by inoculating short ragweed (SRW) pollen. After the SRW pollen challenge, the mice received a single subconjunctival or tail vein injection of 2 × 106 hUCMSCs, or subconjunctival injection of hUCMSCs conditioned medium (hUCMSC-CM), and dexamethasone eye drops was used as positive control; subsequent scratching behavior and clinical symptoms were assessed. Immunostaining and flow cytometry were carried out to show allergic reactions and the activation of CD4 + T cell subsets in the conjunctiva and cervical lymph nodes (CLNs). Gene expression was determined by RNA-seq and further verified by qRT-PCR and Western blot. Co-culture assays were performed to explore the regulatory role of hUCMSCs in the differentiation of CD4 + naive T cells (Th0) into Th2 cells.

Results

Subconjunctival administration of hUCMSCs resulted in fewer instances of scratching and lower inflammation scores in EAC mice compared to the tail vein delivery, hUCMSC-CM and control groups. Subconjunctival administration of hUCMSCs reduced the number of activated mast cells and infiltrated eosinophils in the conjunctiva, as well as decreased the number of Th2 cells in CLNs. After pretreatment with EAC mouse serum in vitro to mimic the in vivo milieu, hUCMSCs were able to inhibit the differentiation of Th0 into Th2 cells. Further evidence demonstrated that repression of Th2 cell differentiation by hUCMSCs is mediated by CRISPLD2 through downregulation of STAT6 phosphorylation. Additionally, hUMCSCs were able to promote the differentiation of Th0 cells into regulatory T cells in CLNs of EAC mice.

Conclusions

Subconjunctival injection of hUCMSCs suppressed the Th2-allergic response and alleviated clinical symptoms. This study provides not only a potential therapeutic target for the treatment of AC but also other T cell-mediated diseases.
A qualitative exploration of the psychological needs of women survivors of rape in Iran
Authors: Asadi Leila , Noroozi Mahnaz , Salimi Hajar , Mardani Fardin , Jambarsang Sara
Published: October 2023

Background

Rape is one of the principal forms of sexual violence leading to numerous psychological consequences for women. Providing effective psychological services to women survivors of rape requires identifying and considering their real needs. This study aimed to explore the psychological needs of women survivors of rape.

Methods

In this exploratory-descriptive qualitative study, the participants consisted of 19 women survivors of rape and 20 people with experience in providing services to survivors of rape, selected via purposive sampling method in Isfahan, Iran. In-depth individual semi-structured interviews and field notes were used to collect data, which were then analyzed using the conventional content analysis method.

Results

Based on the analysis of the interviews, the psychological needs of women survivors of rape were classified into three main categories: facing psychological problems, attention to emotional reactions, and the need to accept and adapt to reality.

Conclusions

The results revealed that women survivors of rape have different psychological needs. Thus, to meet these needs, supportive and psychological interventions can be considered at both individual and environmental levels. Also, eliminating gender stereotypes affecting the occurrence of rape in the dimensions of Iranian culture can lead to the liberation of the society from the culture of rape.
Scene clusters, causes, spatial patterns and strategies in the cultural landscape heritage of Tang Poetry Road in Eastern Zhejiang based on text mining
Authors: Li Jiayan , Xu Tao , Gu Xiaoyu , Lin Jingyuan , Li Mengyu , Tao Peiyuan , Dong Xinyue , Yao Peng , Shao Ming
Published: October 2023

The burgeoning field of digital humanities has provided important modern technological means for text mining in literary works. Chinese classical poetry, as a treasure in the world’s artistic treasury, holds significant value in recognizing the heritage of world culture. In this study, taking the 1589 Tang poems from the Tang Poetry Road in Eastern Zhejiang as an example, we constructed a research framework that explores the aesthetics of classical Chinese poetry landscapes and spatial imagery at the urban agglomeration scale by utilizing geographic and analytical tools such as Python programming, Gephi co-occurrence semantic networks, and GIS kernel density analysis. The framework exhibits three key innovations: (1) a text processing approach that treats individual characters as semantic units in ancient poetry texts, (2) a combined approach of Python programming techniques and Gephi visualization tool for social network analysis, and (3) a study focusing on the integration of textual and spatial aspects of literary landscape heritage corridors at the urban cluster scale. The constructed framework greatly enhances the efficiency and accuracy of Tang poetry text mining, it enables the extraction of natural and cultural landscape spatial imagery along the Tang Poetry Road, the construction of scene depictions, the identification of key regions within the scenes, and the derivation of location-specific strategies. This study broadens the scope of exploring the cultural heritage value of Tang poetry literature and provides practical guidance for the development of cross-regional heritage corridors.
Misclassification of firearm-related violent crime in criminal legal system records: challenges and opportunities
Authors: Schleimer Julia P. , Mustafa Ayah , Ross Rachel , Bowen Andrew , Gallagher Amy , Bowen Deirdre , Rowhani-Rahbar Ali
Published: October 2023

Background

Criminal legal system data are one source for measuring some types of firearm-related harms, including those that do not necessarily result in injury or death, but measurement can be hampered by imprecise criminal code statutes. We quantified the degree of misclassification in Washington state criminal codes for measuring firearm-related crime.

Findings

In this study of individuals aged 18 years and older who were convicted of a misdemeanor in Washington Superior Courts from 1/1/2015 through 12/31/2019, we compared firearm-related charges as measured with criminal codes and with manual review of probable cause documents, considered the gold standard. The sample included 5,390 criminal cases. Of these, 77 (1.4%) were firearm-related as measured with criminal codes and 437 (8.1%) were firearm-related as measured via manual record review. In the sample overall, the sensitivity of criminal codes was 17.6% (95% CI 14.2–21.5%), and negative predictive value (NPV) was 93.2% (95% CI 92.5–93.9%). Sensitivity and NPV were higher for cases with exclusively non-violent charges. For all cases and for cases with any violent crime charge, firearm-related crimes described in probable cause documents most often involved explicit verbal threats, firearm possession, and pointing a firearm at or touching a firearm to someone; almost 10% of all cases involved shooting/discharging a firearm. For cases with exclusively non-violent charges, the most common firearm-related crime was unlawful possession.

Conclusions

Criminal records can be used for large-scale policy-relevant studies of firearm-related harms, but this study suggests Washington state criminal codes substantially undercount firearm-related crime, especially firearm-related violent crime.
Teaching evidence-based practice to physiotherapy students in Italy: a cross sectional study
Authors: Piano Leonardo , Chiarotto Alessandro , Mascarello Marco , Turolla Andrea , Cecchetto Simone , Gianola Silvia , Castellini Greta
Published: October 2023

Background

Evidence-based practice (EBP) is being rapidly adopted by the Italian physiotherapy community, although a knowledge gap persists at clinical level with consequent lack of integration of EBP into ground roots practice. Teaching of EBP during the Bachelor of Science (BSc) undergraduate course in physiotherapy likely has a vital role to play in the spread of knowledge, providing a grounding in the fundamental concepts of EBP.

The aim of the present study was to investigate the prevalence of EBP educational content in Italian BSc courses in physiotherapy.

Methods

This is a cross-sectional study during which characteristics of EBP teaching in BSc degree courses of physiotherapy in Italy were collected from institutional websites during the period May to September 2021 with an update in August 2022. We used the STrengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines for our manuscript.

Results

Forty-two physiotherapy BSc degree programs were retrieved, accounting for all the BSc delivered in the 2021–2022 academic year. Fourteen of these (33.3%) did not report EBP content. Northern universities provided EBP content in 16 out of 18 (88%) degree courses. Central Italian universities provided EBP content in 6 out of 9 (66.6%) degree courses. Southern universities delivered EBP content in 3 out of 9 (33.3%) degree courses. The universities of Sicily and Sardinia provided EBP content in 2 out of 5 (40%) degree courses.

The degree courses taught in public universities were more likely to contain EBP material (25 out of 37, 67.4%), compared to those taught within the private system (3 out of 5, 60%).

Conclusions

The prevalence of EBP content within physiotherapy BSc degree programs in Italy can be considered suboptimal, with both regional differences and according to the system (public vs private). The results of this study could be used as a stimulus for increasing investment in the teaching of EBP in Italian physiotherapy degree courses, thereby improving educational standards.
Heritage of the Anatolian geography: registered varieties of ancestral wheat (siyez, gacer, and menceki)
Authors: Onur Merve , Ceylan Firuze
Published: October 2023

Turkey is one of the major regions of wheat cultivation where wheat has economic, social, cultural, and archaeological values. The Anatolian lands are the homeland of wheat and the gene center of ancestral wheat varieties. Having survived without any genetic modification, ancestral wheat is a biological and cultural heritage. The rich nutritional value, unique flavor, and aroma of ancestral wheat varieties make them more valuable than their modern equivalents. However, prioritizing the production of modern wheat varieties has prompted the oblivion of ancestral ones and a decline in their production. This study aimed to raise awareness about the registered ancestral wheat varieties (i.e., siyez, gacer, and menceki), the cultural heritage of Anatolia, which has sunk into oblivion. To this end, it tackled the general characteristics of ancestral wheat varieties, an indispensable part of the Turkish cuisine, their nutritional value, and their use in local cuisines. Increasing the use of these registered ancestral wheat varieties in local culinary cultures and ensuring the sustainability of local values increases the significance of this study.
Anisotropy-driven velocity log reconstruction in deviated wells: A case study from deepwater Sadewa Field
Authors: Oktariena Madaniya , Triyoso Wahyu , Sukmono Sigit , Fatkhan Fatkhan , Septama Erlangga , Wardaya Pongga D. , Murdianto Befriko S.
Published: October 2023

Deviated drilling is a common cost-cutting strategy used in efforts to develop deepwater hydrocarbon fields. By utilizing the existing platform, new wells are drilled with a particular inclination to reach the intended depth level as a branch of the main vertical well. Drilling at inclination results in a change in the direction of observation from data collection. This change will affect the measured magnitude value when well logging is carried out, especially on physical parameters sensitive to the direction of the measurement such as velocity. Distortion of velocity values due to the orientation effect of data collection has been a limiting factor in seismic analysis because of phase changes during the well-to-seismic tie, inconsistent amplitude variation with offset responses, and ambiguity in the appearance of the hockey stick effect on long-offset seismic data. The oil and gas industry is starting to move toward developing concepts that link the presence of anisotropy recorded in field data with the possibility of hydrocarbon reservoirs. Velocity logging (sonic and shear sonic) should begin to get more attention to support this strategy of making data retrieval results more precise. The motivation of this study is to apply the method of calculating velocity compensation values to reconstruct sonic and shear sonic logs in deviated wells by utilizing anisotropy parameters. By reconstructing the velocity log, the authors attempt to verticalize the log to return the log function to represent subsurface conditions.
Seismic Soundoff: The sound of seismic
Authors: Geary Andrew
Published: October 2023

Paolo Dell'Aversana highlights his recent article in The Leading Edge, “An expanded idea of imaging in geophysics through multimodal data analysis.” The article explores a dual-sensory approach to understanding seismic data. This episode unlocks secret information hiding in seismic data that is waiting to be discovered.
Development of Hyperpolarized NMR Molecular Probes for Biological Applications
Authors: Sando Shinsuke
Published: October 2023

Our bodies are composed of molecules. The dynamic activity of molecules is the essence of living phenomena. Toward the analysis of this, the establishment of in vivo molecular imaging techniques has been sought. Hyperpolarized nuclear magnetic resonance (NMR) is a promising technique that enables in vivo molecular imaging using highly sensitive hyperpolarized NMR molecular probes and is expected to be a next-generation molecular imaging technology. However, a major challenge lies in the rapid relaxation of the hyperpolarized nuclear spin state of the molecule, i.e., a short lifetime of high sensitivity. We have made our efforts to address this critical issue. This award account mainly describes our research to develop hyperpolarized molecular probes with long hyperpolarization lifetime. Based on the understanding of the relaxation mechanism of hyperpolarized spin states, we successfully developed various hyperpolarized 13C molecular probes, some of which were applied for in vivo studies. In addition, we demonstrated the development of hyperpolarized 15N molecular probes with remarkably long hyperpolarization lifetimes. These results pave the way for the rational design of hyperpolarized molecular probes, which has been difficult to achieve so far.
Manual educacional do ensino remoto
Authors: Kubrusly Marcos , Lopes Ferreira Lima Danilo , Kubrusly Sobral Juliana
Published: October 2023

Este manual, fruto do Curso de Mestrado Profissional em Ensino na Saúde e Tecnologias Educacionais, apresenta, como fonte de pesquisa, o ensino remoto por meio de nova ferramenta de aplicação em situações vigentes. O presente instrumento tem o propósito de abordar as nuanças advindas da nova opção de ensino decorrente do momento pandêmico pelo qual os educadores e estudantes tiveram que passar, assim como as expectativas em relação ao ensino pós-pandemia. O distanciamento social, provocado pela pandemia da Covid-19 e o ensino remoto emergencial potencializaram o desenvolvimento dos professores, oportunizando, assim, novas aprendizagens profissionais. Com base nisso, expomos aqui, também, os atuais modelos aplicados pelos profissionais da educação com o fito de suprir as deficiências advindas desse novo desenho educacional proposto pela pandemia do Coronavírus. Este manual traz informações relevantes acerca do ensino remoto emergencial. Fazer uma leitura atenta a ele poderá trazer a você, leitor, mais esclarecimentos quanto ao novo cenário mundial de educação.
INTELLECTUAL CAPITAL OF A UNIVERSITY AS A COMPONENT OF ITS RATING ASSESSMENT: OPPORTUNITIES FOR MANAGEMENT ACCOUNTING
Authors: Vakhrushina Mariya
Published: October 2023

Intellectual capital is a relatively new term in economics. It includes knowledge, skills, production experience, patents, databases, software, trademarks used in the activities of economic entities. Intellectual capital, first of all, is inherent in knowledge-intensive activities, in which a significant place belongs to the activities of universities. Despite the unfavorable geopolitical situation, universities in our country remain participants in Russian and international rankings, based primarily on data on their intellectual capital. At the same time, not only its financial, but also its image component depends on the place of a university in the ranking. In this regard, objective disclosure of information about the intellectual capital of universities becomes an urgent task. The formation of ratings is currently carried out under conditions of presentation of incomparable data, which is explained by the lack of an adequate information base for their formation. In this regard, in the presented study, the management accounting system of universities is positioned as an information base for preparing information about their intellectual capital. It is proposed to include the block “University Intellectual Capital” in the management accounting framework of Russian universities, which accumulates information about its components - human, client and organizational capital. The study substantiates a system of indicators to be included in this block both at the stage of formation of university management accounting and during its subsequent development. Adding the “University Intellectual Capital” block to the university management accounting system will not only increase the reliability of information about the university’s intellectual capital, but will also ensure greater objectivity in conducting rating assessments of their activities. In addition, this solution will allow reformatting existing information flows of universities, avoiding their repeated duplication.
The Problem of Emotional Well-Being of Preschool Children in the Context of Child-Parent Relationships: Experience of Empirical Analysis
Authors: Du Yuan
Published: October 2023

Parents play a crucial role in the emotional development of children during their early childhood. Actions, reactions, parental attitudes all have a powerful impact on a child's emotional well-being, laying the foundation for their social experience and mental health. This article highlights the results of an empirical study that was aimed at identifying the relationship between parent-child relationships and the emotional well-being of preschoolers. The sample of respondents consisted of children of preschool age (90 people) and their parents (150 people). The survey was conducted based on the children's educational institution «Maple Bear» in the city of Zhengdong (People's Republic of China). The analysis showed that the parental attitude towards children with a low level of emotional well-being is characterized by a mismatch between the emotional, cognitive, and behavioral components; Parental attitudes toward children with high emotional well-being are less controversial than those shown by parents towards their children with low emotional well-being.
O meu sonho? Ter uma casa. Pensar sobre habitação, cidade e cidadania das mulheres no Portugal revolucionário (1974-1976).
Authors: Antunes Lia
Published: October 2023

O Serviço de Apoio Ambulatório Local (SAAL, 1974-1976) foi uma iniciativa única na cultura arquitetónica portuguesa, sobretudo pela dimensão sociopolítica da disputa da casa e da cidade a partir das e dos moradores pobres urbanos. As mulheres foram protagonistas. Exploro as motivações e as contribuições de moradoras e técnicas no desenvolvimento do SAAL/Norte. A partir do programa televisivo Nome Mulher (1975-1976), pergunto sobre qual a relação da luta pelo direito à habitação com a construção da cidadania das mulheres no contexto da participação no processo SAAL. Metodologicamente, o levantamento dos assuntos abordados no programa são alinhados com o episódio Direito à Habitação (1976), no qual uma arquiteta e moradoras do SAAL/Norte falam na primeira pessoa. A análise interseccional do grupo “mulheres do processo SAAL” acompanha a discussão das estruturas sexuais e raciais a partir das quais Carol Pateman (Pateman 2010) sublinha os principais obstáculos à construção da cidadania plena das mulheres: além da feminização da pobreza, também a sub-representação e a atribuição social e histórica dos trabalhos de cuidado às mulheres. Estes têm ainda o potencial de ser entendidos como “gestos políticos radicalmente subversivos” (Hooks 1990). O direito à habitação está intimamente ligado ao direito a ser parte ativa na sociedade (Muxi 2009) e ao direito à cidade, conceito que tem sido ampliado por teóricas feministas (Pérez 2013). A par da representação das mulheres, defendo que o acesso a uma habitação – digna, adequada e lugar de individualidade e descanso - é um pilar na efetivação da cidadania plena das mulheres.
Lavandería comunal de Pelican Bay. Narrativas espaciales feministas del Patrimonio Cultural de Santa Cruz, Archipiélago de Galápagos.
Authors: Ramos-Pasquel Daniela
Published: October 2023

La única Historia escrita sobre las Galápagos privilegia los discursos relacionados con las áreas protegidas y los bienes naturales inscritos en la lista de Patrimonios Mundiales de la UNESCO (1978). Este relato excluye de la memoria colectiva a otros patrimonios y, particularmente, la participación de las mujeres en su construcción. Por tanto, el propósito de este artículo es restaurar las memorias de las mujeres en el contexto del patrimonio cultural de la isla Santa Cruz, reconociendo la importancia de la sostenibilidad de la vida (Carrasco 2009) y los cuidados como prácticas esenciales, tanto materiales como inmateriales, en los procesos de configuración y habitabilidad territorial. Para conseguir este objetivo, se utilizó la escritura como práctica espacial. Resignificando las narrativas patrimoniales en torno a Pelican Bay, al incorporar la lavandería comunal y las espacialidades construidas a partir de las experiencias de género. De esta manera, las narrativas espaciales feministas amplían los márgenes de la única Historia, incorporando a las mujeres, sus conocimientos y sus prácticas como otras formas de entender y gestionar el territorio.
Nieznana miniatura z rękopisu Ms 54 w archiwum kapitulnym na Wawelu. Przyczynek do dziejów kultu św. Anny w katedrze krakowskiej
Authors: Macioł Elżbieta
Published: October 2023

The Archives of the Wawel Cathedral Chapter house a Latin liturgical book called “Antiphonariumde sanctis”, sign. Ms 54, dated to around 1470, with its final section addedin 1515 during the binding of the codex. That section includes an unknown miniature:Saint Anne Trinitarian Adored by a Priest. The Renaissance depiction presents a NorthernEuropean variation of this iconographic motif. The miniature was painted whenthe cult of Saint Anne Trinitarian within the Cracow Cathedral circles reached its peak.It flourished here, as it is known based on foundations, for two centuries – from the late14th to the late 16th century. The manner of representation in the miniature emphasizesthe priesthood of Christ and the sacrament of priesthood.
„Libri Fundationis” – księgi fundacji Krakowskiej Kapituły Katedralnej z lat 1606-1912
Authors: Maroszek Piotr
Published: October 2023

The article discusses the specifics of a series of the foundation’s books created duringthe early modern period by the Cracow Cathedral Chapter and stored in its archives(ref. No. LF 1-65, 67-110). These books rarely appear in the literature connectedwith church foundations, although, as noted by some researchers, they constitutevaluable source material. Their usefulness in scientific research has also been demonstrated,with a particular focus on the issue of charitable activities of the Church – thebooks of the foundation contain rich material in this scope. Some volumes fromthe “Libri Fundationis” series also possess certain artistic value. They serve asa testimony to the extensive and diverse activities conducted by the Cracow CathedralChapter.
Związki ks. Romana Spithala ze zmartwychwstańcami
Authors: Gawlik CR Maciej
Published: October 2023

Father Roman Spithal, a priest of the Tarnów Diocese since 1851, considered the possibilityof joining the Congregation of the Resurrection for novitiate formation twice(in 1863 and in the years 1867-1868). However, numerous obstacles on his own part,as well and some reservations regarding his plans from Father Piotr Semenenko andFather Hieronim Kajsiewicz, two co-founders of the congregation, prevented it fromhappening. In 1869, Father Spithal transferred to the Cracow Diocese, where he roseto the position of a prelate custodian of the Cracow Chapter. Throughout this time, hetreated the Resurrectionists with great kindness and appreciation.