bluuebunny/crossref_metadata_2025 huggingface dataset:
Xenobiotic Removal by Trametes hirsuta LE-BIN 072 Activated Carbon-Based Mycelial Pellets: Remazol Brilliant Blue R Case Study
Authors: Glazunova Olga. A. , Moiseenko Konstantin V. , Fedorova Tatyana V.
Published: December 2023

As a toxic xenobiotic compound, the anthraquinone dye Remazol Brilliant Blue R (RBBR) poses a serious threat to aquatic ecosystems. In the present study, the ability of Trametes hirsuta to remove RBBR from the medium was investigated, and the role of adsorption by fungal mycelium and biodegradation by fungal enzymes was evaluated. It was shown that the whole fungal culture was able to remove up to 97% of the dye within the first four hours of incubation. Based on enzymatic activities in the culture broth, laccases were proposed to be the main enzymes contributing to RBBR degradation, and RT-qPCR measurements demonstrated an increase in transcription for the two laccase genes—lacA and lacB. Composite mycelial pellets of T. hirsuta with improved adsorption ability were prepared by adding activated carbon to the growth medium, and the induction of laccase activity by carbon was shown. For composite pellets, the RBBR decolorization degree was about 1.9 times higher at 1 h of incubation compared to carbon-free pellets. Hence, it was shown that using fungal mycelium pellets containing activated carbon can be an effective and economical method of dye removal.
Lethal Toxicity of Thymus mastichina and Helichrysum italicum Essential Oils to Non-Target Aquatic Organisms: Tools to Screen Environmental Effects?
Authors: Afonso Sandra , Nogueira Juliana , Cavaleiro Carlos , Ferreira Fernanda , Moreira-Santos Matilde
Published: December 2023

Essential oils (EOs) from Thymus mastichina (EO-thyme) and Helichrysum italicum (EO-curry) have wide commercial applications, but little is known about their ecotoxicity to aquatic life. We evaluated the lethal toxicity of both EOs toward standard freshwater (Daphnia. magna and Thamnocephalus platyurus) and saltwater (Artemia sp.) species. Dimethylsulfoxide was used as a solvent after establishing a maximum safe but effective concentration of 1% (v/v). EO-curry was significantly more toxic than EO-thyme (24–48 h LC50 values of 15.93–55.80 and of 84.78–153.0 mg L−1, respectively) for all species; sensitivity ratios ranged from threefold for D. magna (48 h) and Artemia sp. (24 h) to fivefold for T. platyurus (24 h). Artemia sp. was the least sensitive, and T. platyurus was the most sensitive species, although significantly more so than D. magna only to EO-curry. The second major compound in EO-thyme, β-pinene (5%), is more toxic to aquatic life than major compound 1,8-cineole (62%), although 1,8-cineole facilitates penetration of other EO constituents into crustaceans’ epidermis. Among the main compounds of EO-curry, only α-pinene (13%) is known to be toxic to aquatic organisms. However, minor compounds present in both EOs, like p-cymene (0.3–1.1%), also cause synergistic effects by enhancing the penetration of other EO constituents. Before any of these standard tests can be recommended for the ecotoxicity characterization and environmental management of EOs, their sensitivity to a wider range of EOs, at least from closely related families, needs to be assessed.
Comparative Study of Geospatial Techniques for Interpolating Groundwater Quality Data in Agricultural Areas of Punjab, Pakistan
Authors: Tayyab Muhammad , Aslam Rana Ammar , Farooq Umar , Ali Sikandar , Khan Shahbaz Nasir , Iqbal Mazhar , Khan Muhammad Imran , Saddique Naeem
Published: December 2023

Groundwater Arsenic (As) data are often sparse and location-specific, making them insufficient to represent the heterogeneity in groundwater quality status at unsampled locations. Interpolation techniques have been used to map groundwater As data at unsampled locations. However, the results obtained from these techniques are affected by various inherent and external factors, which lead to uncertainties in the interpolated data. This study was designed to determine the best technique to interpolate groundwater As data. We selected ten interpolation techniques to predict the As concentration in the groundwater resources of Punjab, Pakistan. Two external factors, the spatial extent of the study area and data density, were considered to assess their impact on the performance of interpolation techniques. Our results show that the Inverse Distance Weighting (IDW) and Spline interpolation techniques demonstrate the highest accuracy with the lowest RMSE (13.5 ppb and 16.7 ppb) and MAE (87.8 ppb and 89.5 ppb), respectively, while the Natural Neighbor technique shows the lowest accuracy with the highest RMSE (2508.7 ppb) and MAE (712.1 ppb) to interpolate groundwater As data. When the study area’s extent was modified, IDW showed the best performance, with errors within ±1.5 ppb for 95% of the wells across the study area. While data density has a positive correlation with interpolation accuracy among all techniques, the IDW remained the best method for interpolation. It is therefore concluded that IDW should be used to interpolate groundwater quality data when observed data are sparse and randomly distributed. The utilization of IDW can be useful for As monitoring and management in groundwater resources.
Simulation Study on the Mechanical Effect of CO2 Geological Storage in Ordos Demonstration Area
Authors: Li Chang , Hao Shuren , Zhang Shengjie , Jiang Yongqing , Yi Zhidong
Published: December 2023

In order to understand the long-term process of CO2 storage and demonstrate its safety, multi-field coupled numerical simulation is considered a crucial technology in the field of geological CO2 storage. This study establishes a site-specific homogeneous thermo-hydro-mechanical coupling model based on TOUGH-FLAC3D coupling program using actual stratigraphic data from the Ordos demonstration area. The analysis investigates the transport behavior of CO2 within the formation considering pore permeability homogeneity, incorporates redistribution of effective stress and rock deformation, and provides a mechanical evaluation of the effectiveness of CO2 sequestration at this specific site. The findings indicate that: (1) the sealing effect of the cap rock depends on the difference of permeability between the reservoirs. The greater the permeability difference, the better the sealing effect. (2) High pore fluid pressure can lead to a decrease in the effective stress of rocks, causing deformation. After simulation calculations, the maximum deformation of rocks can reach 7.79 mm within a decade of CO2 injection. (3) Under the condition of continuous CO2 injection, the pore pressure will not be able to dissipate quickly and will continue to rise, and eventually shear failure will occur in the rock layer, but it is mainly concentrated in the lower part of the cap rock.
Optimization of chronic periodontitis comprehensive treatment
Authors: Bulgakov A. I. , Soldatova E. S. , Kuvardina Yu. O.
Published: December 2023

Relevance. The increasing prevalence of mild to moderate chronic generalized periodontitis depends on endogenous and exogenous factors. In most cases, these include factors such as fair oral hygiene, oral microbiota characteristics, increased loads on periodontium, malocclusion, smoking, history of systemic disorders, genetic predisposition, neuroses, etc. Despite the variety of available treatment protocols for mild to moderate chronic generalized periodontitis, the result has a short-term effect. Thus, searching for new treatment algorithms and creating improved medications with the necessary properties to stabilize the process and prolong remission in chronic periodontitis are relevant. The study aimed to evaluate the effectiveness of the comprehensive chronic periodontitis treatment with netilmicin ointment and propolis extract combined with diode laser, considering periodontal and immune statuses.Material and methods. The study involved 70 patients with mild and moderate chronic generalized periodontitis and 30 controls without signs of inflammatory periodontal diseases (IPD). The main group consisted of 50 patients with IPD, who had comprehensive treatment with the ointment based on netilmicin and propolis extract and antiinflammatory therapy using the Doctor Smile diode laser. The comparison group comprised 20 patients whose treatment protocol did not include laser treatment. We conducted a clinical and immunological study of patients before and after the treatment.Results. The comprehensive treatment evaluation, including clinical and immunological analysis, revealed a significant improvement in the parameters when using a combination of ointment with netilmicin/propolis extract and laser therapy, compared to standard non-surgical treatment.Conclusion. The clinical and immunological analysis of the comprehensive treatment of patients with chronic periodontitis has established the advantage of the combined use of non-surgical treatment and physiotherapy procedures.
Network philosophy of artificial rationality: effects of interaction of multi-level systems. Part 2
Authors:   St. Petersburg State University., Kondratenko K.S.
Published: December 2023

The article is a continuation of the study of artificial rationality published earlier. The article explores the space of technical rationality, simulates a non-spontaneous rational system based on structural functionalism, system and network analysis, conducts a thought experiment on the possibility of having technical systems more spontaneous, and also introduces the concept of rationally indeterminate systems, which describes the impossibility of a complete understanding and control over technology. In conclusion, the author discusses the significance and prospects of the study.
Creative Urban Spaces as Variations for Building an Image of the Future for “Extended Self”
Authors:   Yaroslav-the-Wise Novgorod State University, Shavlokhova A.A.
Published: December 2023

The author of the article proceeds from the hypothesis that the “extended” personality is a complex, multi-component concept of our reality. And, as part of the implementation of communicative practices, in creative urban spaces, the younger generation can change their idea of the image of the future, creating a new semantic paradigm. The relevance of the study is due to the fact that the consequences of the pandemic and the inability to visit urban places for a certain time have negatively affected young people’s ideas about their own future (foreign studies). The author of the work made conclusions regarding the place of the “Extended Self” in the process of creating Significance in the design of the future. The applied significance of the research lies in the need to create a conscious urban space that will help attract young people to the ideas of creating a new future in their own country.
An Anomaly Detection Method for Weighted Data Based on Feature Association Analysis
Authors: Li Jiayao , Wang Rui
Published: December 2023

In recent years, weighted data is appearing more and more frequent in many applications, but the existence of anomalies decreases the accuracy of data-based operations, thus, it is necessary to detect anomalies to improve the data quality. However, the existing anomaly detection methods for weighted data only consider the Weighted Frequent Itemsets (WFIs) or Weighted Rare Itemsets (WRIs) separately, which causes their detection accuracy is seriously dependent on the preset minimal weighted support (min_wsup) value. To address these issues, we propose an anomaly detection method for weighted data on the basis of feature association analysis, namely ADWD, it accurately detects the anomalies under different min_wsup values through fully considering both WFIs and WRIs. ADWD first deletes infrequent 1-itemses during constructing Weighted Frequent itemset-based Tree (WFI-Tree), thus decreasing time overhead on the inquiry of extensible itemsets; And then, ADWD defines three deviation metrics through comprehensively considering possible influencing factors to calculate transaction’s abnormal score. Finally, the transactions whose abnormal score in top-rank are judged as anomalies. Extensive experiments on three datasets verify that the proposed ADWD method can more accurately detect anomalies from weighted data within less time usage, as well as has good scalability.
F. Battistoni (ed.), Polibio e Roma, l’alba di un impero, Roma: Carocci editore, 2022,
Authors: Carral Ignacio
Published: December 2023

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Debates y combates en torno a Bourdieu y la fenomenología
Authors: Dukuen Juan
Published: December 2023

En este trabajo se analizan una serie de debates sobre la relación entre la teoría de la práctica de Bourdieu y la tradición fenomenológica. Se comienza revisando la crítica de Throop & Murphy a la lectura realizada por Bourdieu de Husserl y Schutz y la respuesta del sociólogo francés. Luego se propone un análisis crítico de este debate, mostrando aciertos y desaciertos de cada posición. A continuación, se retoman los trabajos de Haber y Bimbenet, que evidencian la fundamentación de la perspectiva de Bourdieu en Merleau-Ponty -subestimada por Throop & Murphy- sin dejar de señalar una crítica a los límites de la teoría de la práctica. Se concluye que sus principales objeciones a Bourdieu giran en torno al “determinismo” y a su poca atención a las “prácticas reflexivas”. Se responde a esas críticas mediante una reelaboración de la antropología de Bourdieu a partir de la integración profunda de la fenomenología de Merleau-Ponty, centrada en la dialéctica entre cuerpo habitual y actual, reflexividad y contradiestramiento corporal.
La relación entre fenomenología y ciencias en La Estructura del Comportamiento. Merleau-Ponty y el proyecto de naturalización de la fenomenología
Authors: Libonati Fernando
Published: December 2023

El objetivo del presente trabajo es argumentar que la obra de Maurice Merleau-Ponty, y principalmente La Estructura del Comportamiento, se puede considerar como precursora del proyecto de naturalización de la fenomenología. A tal efecto, se expondrá la propuesta de cada una de las cinco vías posibles para acometer dicho proyecto estipuladas en Naturalizing Phenomenology, y simultáneamente se evaluará su compatibilidad con la posición del fenomenólogo. A fin de justificar la comparación propuesta, se explicitará que las tesis centrales de las vías mencionadas se pueden reconocer, si bien formuladas desde distintos marcos teóricos, en las posiciones de los autores con los que Merleau-Ponty dialoga. Se concluirá que el abordaje merleau-pontyano puede caracterizarse como un tránsito desde la tercera vía, denominada mutual constraining, hacia la cuarta, que consiste en proponer una ampliación del concepto de naturaleza.
El “spinozismo” de Leibniz en el De summa rerum
Authors: Jabase Leila
Published: December 2023

En el presente artículo abordamos la relación filosófica entre Spinoza y Leibniz, y planteamos la hipótesis de que Leibniz tuvo un período amistoso con éste, en el que llegó a sostener ideas spinozistas. En particular, analizamos la concepción monista de la substancia que creemos puede encontrarse en algunos de los escritos metafísicos del período 1675-1676, hoy conocidos como De summa rerum. Planteamos que la relación entre lo uno y lo múltiple, uno de los problemas con mayor pregnancia en el sistema leibniziano, encontrará en la filosofía de Spinoza una formulación de gran atractivo para el joven filósofo. Asimismo, atenderemos a algunas de las diferentes lecturas que pueden encontrarse sobre la influencia spinoziana en Leibniz.
Una lengua en erección. Las reverberaciones sadeanas de Alejandra Pizarnik
Authors: Molina Cristian
Published: December 2023

Nos proponemos leer las reverberaciones de las imágenes sadeanas en las múltiples escrituras de Alejandra Pizarnik: en su correspondencia, diarios, textos en prosa y poemas. Ello supone redefinir lo sadeano como un modo de la imaginación —y, por ende, del pensamiento— que no se circunscribe a lo “sádico” como práctica sexual, ni tampoco como obra del marqués de Sade, sino que se presenta en tanto configuración singular de lo sensible que atraviesa los tiempos y las culturas. Nos interesa señalar cómo fue leída por la crítica la relación de Alejandra Pizarnik con el marqués de Sade, solo a partir de la atención sobre un conjunto de textos breves y en prosa. A diferencia de estas polémicas, sostenemos que las imágenes sadeanas reverberan en toda la escritura de Pizarnik, trazando momentos de intensidad variable y poniendo en discusión la idea de una temporalidad lineal que oficiaría de pasaje de una escritura a otra. Lo pizarnikiano de las imágenes sadeanas aparece, a veces en simultáneo, en una superposición con el masoquismo, así como en una monstruosidad femenina y lesbiana que desata una lengua de las monstruas corporal y risible que apenas aparece en sus poemas.
La fábrica de chocolate. Trabajo, género y edad en la industria del dulce, Buenos Aires 1900-1943
Authors: Stagno Leandro
Published: December 2023

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Vidas escandalosas. Antología de la diversidad sexual en textos literarios latinoamericanos de 1850 a 1950
Authors: Mitidieri Gabriela
Published: December 2023

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Automated Indonesian Text Augmentation with Web-Based Application Using Flask Framework
Authors: Rahma Iftitah Athiyyah , Suadaa Lya Hulliyyatus
Published: December 2023

Text classification is one of the fundamental tasks in natural language processing (NLP). In the real world, data and resources available for text classification are limited. One of the issues with labeled data is imbalanced data. The problem of imbalanced data affects the performance and accuracy of the model because the model only focuses on data with majority labels. This impacts the model performance, which tends to classify correctly for the majority label only. Meanwhile, in some cases, it is more important for the minority label to be predicted correctly. Therefore, the measure of model accuracy cannot describe the true performance of the model. To overcome this, an oversampling approach is carried out. Text-based oversampling is known as text augmentation. However, NLP resources for the Indonesian language are still limited, especially in performing text augmentation. Therefore, this research conducts the development of a web application to augment Indonesian text automatically. The application was built using the prototype method. Users can perform augmentation automatically for the entire text in the dataset. Users can select preferred augmentation techniques and are required to upload datasets as input. The output of the application is the same dataset file as the input, with an additional column containing synthetic text augmented by the application.
Energy Poverty and Its Determinants at Subnational Level of Indonesia in 2021
Authors: Anandia Ramadanti Salbila , Andriana Sofa Wahyuni
Published: December 2023

In the coming decades, the energy sector will soon be faced with three major transformations, one of which is energy poverty. The World Economic Forum defines energy poverty as people's limited access to modern energy services and products. Access to modern energy has not been fully met for all regions in Indonesia and disparities between regions still occur. For this reason, indicators are needed to measure the level of energy poverty at both the national and district/city levels. This study aims to analyze energy poverty in Indonesia and determine its determinants using the Multidimensional Energy Poverty Index (MEPI) approach. The data used is the March National Socio-Economic Survey and BPS Village Potential in 2021. This research uses Geographically Weighted Regression (GWR) to determine the determinants of Indonesia's multidimensional energy poverty at the district/city level in 2021. It was found that there were still inequalities in energy poverty conditions in most of Indonesia's districts/cities. Analysis using the GWR model resulted in 66 regional groups that were grouped based on the similarity of variables that had a significant effect. The level of influence of the independent variables vary across districts/cities as consequence of spatial heterogeneity in the data.
IDENTIFYING KEY FACTORS AND TRENDS AFFECTING FOREST USE
Authors: Tretyakov A. , Eremeev Ivan , Karamyshev Viktor , Kolarzh Vyacheslav , Mosolova Natal'ya , Mayorov Igor' , Stepanova Yu.
Published: December 2023

This article reflects the problems of economic valuation of natural forest resources, which have been in the field of interest of researchers since the mid-1960s. From time to time, their narrow sectoral aspect has shifted towards modern research that evaluates the prospects for forest use based on PEST analysis describing regulatory, economic, social and technological factors. Today, as part of the implementation of the concept of sustainable development, forest resources are assessed from the point of view of national forest wealth, as a dominant part of obtaining additional forest income. The need was noted to conduct a study using a questionnaire using the Delphi method for forestry specialists, which made it possible to identify the most significant factors influencing the future development of the industry: by degree of influence (low, medium, high) and by the nature of the impact (negative; neutral; positive). The assessment results obtained using PEST analysis can be applied in practice in solving industry problems in terms of stimulating domestic demand for forestry products; development of recreational activities and infrastructure on forest lands; expansion of domestic tourism, that is, in the context of implementing important forestry tasks from the perspective of preserving forest resources and budget revenues.
The use of corporate external environmental reporting in the evaluation of the state environmental policy
Authors: Godawska Justyna
Published: December 2023

The condition for carrying out an evaluation of the environmental policy is the availability of relevant information. One source of this information could be corporate external environmental reporting. The aim of the article is to determine to what extent the applicable UE legal regulations, Global Reporting Initiative (GRI) and Task Force on Climate-related Financial Disclosures (TCFD) guidelines for corporate environmental reporting enable the use of the disclosed information by enterprises in the assessment of the state environmental policy. The content analysis of legal acts and guidelines was used in the research. The applicable EU legal regulations, GRI and TCFD guidelines enable the use of corporate environmental reporting in evaluating environmental policy mainly in terms of environmental efficiency and, to a small extent, in terms of cost-effectiveness and implementation feasibility.
Doğal Orman Yangını (Örtü Yangını) ve Sahipli Tarım Arazisinde Anız Yakma Uygulamalarının Bazı Toprak Özellikleri Bakımından Karşılaştırılması
Authors: KÜÇÜK Mehmet , TİRYAKİ GÜNGÖR Ayşegül Gözde , KÜÇÜK Ömer
Published: December 2023

Orman yangınları uygun sıcaklık ve nem koşullarında dünya genelinde birçok yerde çalışma konusu olarak ortaya çıkmıştır. Aynı şekilde anız yangınlarda hasattan sonra kalan organik artıkları bertaraf etme açısından kullanılan bir yöntemdir. Bu çalışmada karaçam meşcerelerinde doğal olarak gerçekleşen örtü yangını ile kontrollü anız yakma uygulamalarının bazı toprak özellikleri üzerine etkileri karşılaştırılmalı olarak araştırılmıştır. Bu çalışma kapsamında doğal olarak yanmış karaçam alanları ile anız alanları belirlenmiş ve bu alanların yanmış alanlarından 18 yanmamış alanlarından 18 adet olmak üzere toplamda 36 adet örnekleme noktası seçilmiştir. 0-5cm ve 5-10 cm derinlik kademesi olmak üzere toplamda ise 72 toprak örneği alınmıştır. Bu örnekler üzerinde tekstür, pH, EC, organik karbon, toplam kireç, dispersiyon oranı, toprak su sabitleri (tarla kapasitesi, solma noktası ve FSK) ve agregat stabilitesi analizleri yapılmıştır. Çalışma sonucunda, toprak örneklerinde hem yangının hem de arazi kullanma durumumun (orman tarla) toprak özellikleri üzerinde önemli değişimlere neden olduğu ortaya çıkmıştır. Değişim genel olarak arazi kullanım farklılığı arasında istatistik anlamda önemli düzeyde çıkmıştır. Yangının etkisi de bazı toprak özellikleri üzerinde belirgin düzeyde ortaya çıkmıştır. Anız alanlarındaki değişim daha belirgin şekilde ortaya çıkmıştır. Çalışma sonucu verilerine göre hem ölü örtünün ortamdan uzaklaşması hem de yanma sonucunda besin maddesinin toprağa katılması gibi özellikler düşünüldüğünde doğal alanlarda örtü yangınının uygulanmasının yarar sağlayacağı ortaya çıkmakta ve ormancılıkta kullanılması önerilebilir. Diğer taraftan ise anız uygulamalarının ise mekanik işleme ve ürün hasadı ile verimliliği azalan toprağın toprak özelliklerini dahada kötüleştireceği öngörülmektedir. Bunun yerine tarlanın hasat artıkları ile sürülmesi ya da bir yıl nadasa bırakılarak toprağın dinlendirilmesi gerekmektedir.
Üniversite Öğrencilerinin Depresyon Düzeyleri ve Sınav Kaygı Düzeyleri Arasındaki Ilişkinin İncelenmesi
Authors: PERÇEMKAYA Furkan , ÖZKAN Hasan Hüseyin
Published: December 2023

Bu çalışmada, üniversite öğrencilerinin sınav kaygı düzeyleri ve depresyon düzeyleri arasındaki ilişki incelenmiştir. Araştırmanın örneklemini internet üzerinden gönüllü katılım sağlayan 208 (119 kadın ve 89 erkek) ön lisans, lisans ve yüksek lisans/doktora öğrencisi oluşturmaktadır. Verilerin toplanmasında, Beck (1976) tarafından geliştirilen Beck Depresyon Ölçeği (BDÖ) ve Baltaş (1999) tarafından geliştirilen ve Bahçeci (2006) tarafından güncellenen Sınav Kaygı Ölçeği (SKÖ) kullanılmıştır. Verilerin analizinde; pearson momentler çarpımı korelasyonu, bağımsız örneklem t-testi ve anova teknikleri uygulanmıştır. Araştırma bulgularına göre araştırmaya katılan öğrencilerin depresyon düzeyi puanları ortalaması (11,78) hafif depresyon düzeyine ve kaygı düzeyleri puanları ortalaması (85,60) ise orta şiddette sınav kaygı düzeyine karşılık geldiği saptanmıştır. Buna göre üniversite öğrencilerinin depresyon düzeyleri ve sınav kaygı düzeyleri arasında orta düzeyde (r=0,688) ve pozitif yönde anlamlı ilişki vardır. Araştırmada ele alınan değişkenlerden cinsiyet ve yaş aralıklarına göre öğrencilerin depresyon ve sınav kaygı düzeyleri arasında anlamlı bir farklılık olmadığı ancak üniversite öğretim kademeleri ve fakülte değişkeni açısından anlamlı bir ilişkinin olduğu sonuçlarına ulaşılmıştır.
Análisis bioético en la utilización de animales en la industria farmacéutica
Authors: Linares Márquez Pascual , Jiménez Capriles Mariana Abril
Published: December 2023

En la última década se han incrementado los estudios con animales, avalados por comités de ética o bioética en la investigación científica. Sin embargo, esto no siempre se refleja claramente en los artículos publicados que tienen relación con la industria farmacéutica. La presente investigación, de tipo preliminar, tiene como objetivo analizar los aspectos bioéticos que se establecen en las publicaciones científicas relacionadas con la industria farmaceútica. Asimismo, determinar el compromiso que establecen con el principio de las “Tres Rs” para la procuración del bienestar animal y el establecimiento de mejores condiciones para los animales en la experimentación. En el presente estudio encontramos que la experimentación con animales para generar conocimiento que usa la industria farmacéutica es aplicada a diversas enfermedades humanas. En estos estudios se omiten datos de orden bioético que señalen claramente que los animales utilizados tienen condiciones de bienestar desde su intervención. Concluimos que es fundamental dar paso a una mejor aplicación científica que no demerite las condiciones de los animales intervenidos para generar medicamentos y que el principio de las Tres Rs se aplica muy poco en la experimentación con animales.
KEPEMIMPINAN INKLUSIF DAN PERILAKU KERJA YANG INOVATIF PADA APARATUR SIPIL NEGARA: PERAN KETERLIBATAN KARYAWAN SEBAGAI VARIABEL MEDIASI
Authors: Fatkhurahman Fatkhurahman
Published: December 2023

Aparatur sipil negara memiliki dampak positif yang signifikan terhadap efektivitas dan efisiensi pelayanan publik. Inovasi dalam pelayanan publik dapat membantu meningkatkan kualitas dan responsivitas layanan yang diberikan oleh pemerintah kepada masyarakat. ASN yang memiliki perilaku inovatif dapat menciptakan solusi baru untuk mengatasi tantangan dalam memberikan pelayanan yang lebih baik dan efisien. Penelitian dilakukan di Sekretariat Daerah Propinsi Riau dengan menguji pengaruh kepemimpinan iklusif terhdap perilaku kerja inovatif yang dimediasi oleh keterlibatan karyawan. Sampel diambil sebanyak 200 orang dengan metode proposional random sampling dan analisa data dengan menggunakan alat analisis SEM. Hasil riset meyakinkan kalau kepemimpinan inklusif serta Keikutsertaan kegiatan mempengaruhi dengan cara langsung ataupun tidak langsung kepada sikap kegiatan inovatif. Akibat langsung elastis kepemimpinan inklusif  kepada sikap kegiatan inovatif sebesar 13, 67%, sebaliknya akibat tidak langsungnya lewat Keikutsertaan kegiatan merupakan sebesar 25, 92%. Akibat langsung elastis Keikutsertaan kegiatan kepada sikap kegiatan inovatif sebesar 36%, sebaliknya akibat tidak langsungnya lewat Keikutsertaan kegiatan pimpinan merupakan sebesar 48, 25%. Perihal ini membuktikan kalau keikutsertaan pegawai berfungsi dalam meyakinkan akibat kepemimpinan iklusif kepada sikap kegiatan inovatif.
Discovery of Potential Prolyl-tRNA Synthetase Allosteric Inhibitor Through Virtual Screening and In Vitro Assay against Plasmodium falciparum
Authors: Yuniarta Tegar Achsendo , Sumartha I Gede Ari , Fakih Taufik Muhammad , Handayani Rosita , Ramadhan Dwi Syah Fitra
Published: December 2023

Objectives: This study aimed to identify novel antimalarial compounds based on allosteric inhibitor of prolyl-tRNA synthetase using hierarchical virtual screening.
Materials and Methods: Pharmacophore model was designed initially, based on the structure-activity relationships data between several pyrazole-urea analogues and their IC50 enzymatic value. The model obtained was applied to screen ZINC15 database, after which followed by drug-likeness, toxicophore, and PAINS filter. The hit compounds were docked against P. falciparum prolyl-tRNA synthetase enzyme, using validated docking method. The resulting docking poses were ranked based on the docking score and re-evaluated based on the pharmacophore criteria. Top five compounds were obtained from this step and then evaluated using molecular dynamics simulation to verify its stability and hydrogen bond dynamics over 50 nanoseconds. MM-PBSA analysis was also performed to estimate their binding free energy. Ultimately, their potential bioactivity as antimalarial candidates have been verified against 3D7 strain.
Results: The results showed that all five compounds obtained from virtual screening possess micromolar potency in vitro. Two compounds (ZINC 1029449 and ZINC1029453), yield high antimalarial activity (0.44 and 0.72 μM, respectively)
Conclusions: Overall, the virtual screening approach has successfully produced lead compounds which can be further optimized to be antimalarial agents.
Physicians' Knowledge of Theophylline Use: A Cross-Sectional Study from Jordan
Authors: Ali Tasneem Basheer , Almomani Huda Yousef , Al-Tarawneh Fatima Mahmoud , Alwadi Maysa Waddah , Suliman Ahmad Shaher
Published: December 2023

Objective: This cross-sectional study aims to assess physicians' knowledge regarding theophylline drug and other related characteristics in Jordan.
Materials and Method: The study was conducted prospectively among physicians in Jordan. Physicians were interviewed using an online questionnaire consisting of two sections. The first section included demographics and other relevant characteristics, while the second section comprised questions about theophylline drug.
Results: A total of 385 participants completed the questionnaire. The majority of participants knew that theophylline is used in clinical practice as a bronchodilator (75.6%). Nearly 39% of participants knew that theophylline can be administered orally and intravenously. The largest share of participants (76.1%) did not know that theophylline dosage is calculated based on ideal body weight. Sixty percent of participants knew that theophylline use was not contraindicated during pregnancy. On the other hand, only 27.3% knew that theophylline use was not contraindicated during breastfeeding. The majority of participants (76.1%) had an overall intermediate knowledge of theophylline.
Conclusions: It was noted that physicians had an overall intermediate knowledge of theophylline. Physicians demonstrated unsatisfactory knowledge about theophylline’s indications, clinical use, administration, adverse effects, and other related aspects. These findings highlight the need for educational interventions and training programs to improve physicians’ knowledge of theophylline and enhance its effective and safe use in clinical practice.
Formulation, Development, and Evaluation of Bosentan Monohydrate Spray Dried- Solid Dispersion Tablets for Improved Dissolution Profile
Authors: Raut Sayali , Hajare Ashok , Chougale Rutuja , Kamble Shubham , Patil Kiran
Published: December 2023

Bosentan monohydrate (BM) is utilized for the treatment of pulmonary arterial hypertension, exhibiting poor aqueous solubility and bioavailability. This study aims to enhance the dissolution rate of the drug using Eudragit®EPO through spray drying. The drug and Eudragit®EPO were combined in ratios of 1:1, 1:2, 1:3, 1:4, and 1:5 (w/w) to generate compositions SD1 to SD5. SD5, at a 1:5 drug-to-carrier ratio, demonstrated a statistically significant increase in saturation solubility and drug content. Six tablet formulations (F1 to F6) containing SD5 and tableting excipients were developed and processed. Formulation F2, consisting of 26.36% HPMC K4M and 23.63% MCC, exhibited the highest dissolution and drug release. The probable mechanism underlying BM dissolution in SD involves its amorphous form and the solubilizing effect facilitated by hydrogen bonding between BM and Eudragit®EPO. The carrier's binding effect likely contributed to high tensile strength, low friability, and extended disintegration time. Direct mixing of SD with HPMC might have improved the uniformity of SD within the tablet matrix and the release profile. This study demonstrates the efficacy of spray drying in preparing SD of BM with Eudragit®EPO, potentially enhancing its solubility and stability.
National medium-term priorities of innovation activities and their budgetary support
Authors: Kvasha T. K. , Paladchenko O. F. , Molchanova I. V.
Published: December 2023

Determination and state support of priority areas of innovative activity is one of the ways to ensure the innovative development of the economy.
In Ukraine, 7 strategic priority areas of innovative activity have been approved, according to which 41 medium-term priority areas of the national level have been established, and annual monitoring of their implementation by the main managers of budget funds has been introduced, which is ensured by the Ministry of Education and Science and the Cabinet of Ministers of Ukraine is informed about its results for the possible use of the obtained results at making relevant government decisions.
The article is devoted to the results of the study of the state of implementation of medium-term priority areas of innovative activity at the national level in 2022, which was carried out by the Ukrainian Institute of Scientific and Technical Expertise and Information based on the data of the main managers of budget funds.
A comparative analysis of the obtained results of innovative activities of medium-term priorities of the national level was carried out according to the relevant indicators, and their dynamics were studied. Based on the results of the research, conclusions were made about the relevance of the identified medium-term priorities in the fields of transport, weapons and military equipment; agriculture and environmental protection; optimizing and increasing the effectiveness of the use in 2022 of the funds of strategic areas aimed directly at medium-term priorities while reducing the amount of funding.
It is proposed to intensify the stimulation of the scientific sector to the formation of relevant topics of scientific research aimed at creating innovative developments to ensure the innovative development of the domestic economy.
Mulheres e narração de futebol
Authors: Pacheco Leonardo Turchi
Published: December 2023

Este artigo tem como objetivo refletir sobre os desafios da inserção de mulheres na narração esportiva (futebol). Para tal foram realizadas entrevistas com 48 jornalistas mulheres de quatro capitais brasileiras para compreender alguns dos motivos que fazem da cabine de transmissão de eventos esportivos um espaço de reserva masculina. Depreende-se dos depoimentos e percepções destas que o campo do jornalismo e da narração esportiva é marcado por desigualdades de gênero, onde a voz feminina é desvalorizada em oposição a voz masculina entendida como naturalmente ideal para desenvolver essa atividade.
Mulher, negra e nordestina
Authors: Brum Mariana da Silva , Ribeiro Lóry da Silveira , Lopez Luiza Azevedo , Goellner Silvana Vilodre
Published: December 2023

Este artigo descreve a trajetória de Dilma Mendes, eleita em 2022 como a melhor treinadora do mundo de futebol 7. Fundamentado no aporte teórico-metodológico da História Oral e nos Estudos de Gênero, o texto foi produzido a partir de entrevistas realizadas com a treinadora, cuja narrativa foi colocada em diálogo com outras fontes, como reportagens, sites das entidades que regulam a modalidade, livros, revistas e documentos oficiais, entre outras. Dos entrecruzamentos destas fontes, emergiram três temas: aspectos biográficos de Dilma Mendes, sua atuação no comando de equipes de homens e seu protagonismo à frente da seleção brasileira de futebol 7 feminina.
Scoring a Brace for Dolabela | Dois do Dolabela
Authors: Alvim Renato de Souza , Guimarães Gustavo Cerqueira
Published: December 2023

A FuLiA/UFMG apresenta dois poemas sobre futebol traduzidos do português para o inglês, "Matutu's Blues" e "Depois do jogo"/"After the Match", de Marcelo Dolabela, poeta brasileiro, de Minas Gerais.
Contribuciones para una estrategia pragmática en la cuestión de la responsabilidad criminal de las personas jurídicas
Authors: Ruíz Rengifo Hoover Wadiht
Published: December 2023

La responsabilidad penal de las personas jurídicas es uno de los temas más importantes en el derecho penal económico, ya que pone en tensión la teoría del delito tradicional, construida para un comportamiento individual y no corporativo, es decir, antropocéntrico. Teniendo en cuenta que la cuestión atiende razones político-criminales y desde ese punto de vista la dogmática penal se muestra insuficiente, se propone una estrategia pragmática como la herramienta más eficaz para regular la responsabilidad de las personas jurídicas.
Merdeka Curriculum: Encouraging Creativity and Innovation of Islamic Religious Education Teachers in Madrasah
Authors: Asfiati Asfiati
Published: December 2023

The Merdeka Curriculum is a new curriculum in Indonesia that gives teachers the freedom to develop learning materials and methods that suit students' needs. This research aims to examine the influence of the Merdeka Curriculum on the quality of Islamic Education (PAI) learning. This research uses qualitative methods to understand how the implementation of the Merdeka Curriculum encourages PAI teacher creativity and innovation in three different State Madrasah Aliyah (MAN) schools in the big cities of Medan, Padang and Bukittinggi. Data collection was carried out through in-depth interviews, classroom observations, and study of related documents. Merdeka Curriculum, data analysis was carried out using thematic, narrative and comparative analysis techniques. The research sample consisted of PAI teachers who had implemented the Merdeka Curriculum for more than one year and had sufficient teaching experience. The research results show that the Merdeka Curriculum has positive potential in improving the quality of PAI learning, including a more open and flexible learning approach, the relevance of learning to everyday life, as well as developing the character and ethics of students. However, the implementation of the Merdeka Curriculum in PAI learning also faces several challenges, such as teacher competency and readiness, support from each government and schools in each region, as well as the availability of resources. Comprehensive support from various parties, including government, schools and teachers, is needed to overcome these challenges.
Formulasi dan Evaluasi Fisik Krim Kombinasi Ekstrak Daun Kelor dan Jahe dengan Variasi Konsentrasi Emulgator
Authors: Yuni Rohma , Ulya Tuhfatul , Hardani  , Suhada Adriyan
Published: December 2023

Inflamasi merupakan respon tubuh terhadap kerusakan jaringan yang disebabkan oleh trauma fisik, zat kimia dan zat mikrobiologi. Tanaman yang dilaporkan memiliki aktivitas antiinflamasi adalah daun kelor dan jahe. Penelitian ini bertujuan untuk memformulasi dan mengevaluasi karakteristik fisik sediaan krim kombinasi ekstrak daun kelor dan jahe sebagai krim antiinflamasi. Formula krim disusun berdasarkan variasi konsentrasi emulgator (tween 80 & span 80). Ketiga formula krim selanjutnya di uji organoleptis, tipe krim, daya sebar, daya lekat, nilai pH, dan viskositas selama 14 hari penyimpanan (hari ke 0, 7 dan 14). Hasil uji organoleptis hari ke-0 menunjukkan krim berwarna hijau, bau khas ekstrak, dan berbentuk stabil. Sedangkan hari ke-7 dan 14 menunjukkan warna & bau tetap sama, tetapi krim memisah antara fase minyak dan air, pada ketiga formula. Hasil uji tipe krim hari ke-0,7,14 menunjukkan tipe krim minyak dalam air (M/A) untuk ketiga formula. Hasil uji daya sebar, daya lekat, dan nilai pH tidak berbeda antara ketiga formula baik sebelum ataupun sesudah penyimpanan. Hasil uji viskositas hari ke-0 menunjukkan nilai viskositas F1 (224,600 cPs), F2 (215,100 cPs), F3 (323,100 cPs), sedangkan penyimpanan selama 14 hari menyebabkan terjadinya penurunan nilai viskositas pada ketiga formula krim, dengan nilai viskoitas paling rendah pada formula 2 sebesar 76,290 cPs. Formula krim ekstrak daun kelor dan jahe dengan variasi konsentrasi emulgator memiliki karakteristik fisik yang memenuhi persyaratan nilai pH, daya lekat, daya sebar, dan tipe krim yang tidak berubah selama 14 hari penyimpanan, namun tidak memenuhi persyaratan nilai viskositas dan mengalami breaking pada hari ke-7 dan 14.
Performance analysis of web applications created in the Spring and Laravel frameworks
Authors: Suchanowski Jakub , Plechawska-Wójcik Małgorzata
Published: December 2023

The article compares the performance of two test applications created using the Spring Boot and Laravel application frameworks. The aim of the study is to find an answer to the research question: which framework offers better time performance. Twelve test scenarios were created for the analysis, and they were used to conduct performance tests using the Apache JMeter tool. Additionally, application metrics and community support for both frameworks were compared. The research confirmed that the application built on the Spring Boot framework has better performance.
Comparison of tools for creating and conducting automated tests
Authors: Bielesza Grzegorz Wojciech , Dzieńkowski Mariusz
Published: December 2023

The presented work includes a comparison of three tools for preparing and conducting automated tests - JUnit5, TestNG and Spock. The study, on the basis of which the comparative analysis was carried out, consisted in performing three types of experiments, i.e. performance tests based on five test scenarios, functional tests checking the capabilities of each tool, and tests of popularity and support in the modern context. The performance experiment consisted in configuring the test environment, preparing tests based on scenarios, performing them multiple times, and then verifying and analysing the obtained time results. The comparison of tools capabilities was based on the preparation of a set of key functionalities of the software used to develop tests. The last analysis consisted in comparing the popularity of the surveyed platforms, and was performed on the basis of three popular websites providing information on user activity within the test tool.
KARAKTERISTIK PENGERINGAN SAGU MENGGUNAKAN ALAT PENGERING TENAGA SURYA TIPE RAK1)
Authors: Rawung Feyta Gloria , Ludong Daniel P. M. , Lengkey Lady C. Ch. E.
Published: December 2023

ABSTRACT

 

This study aims to test the performance of a solar dryer for drying sago. Performance tests include: temperature distribution pattern, relative humidity of the air in the drying chamber, changes in moisture content, drying time, and drying rate. The benefits of this research are expected to use a rack-type solar dryer to shorten the drying time and also this tool can provide an overview of the use of solar energy in the process of drying sago and drying other crops. During the drying process there has been a temperature difference between the bottom shelf, middle shelf, top shelf, chimney and ambient air temperature. The average relative humidity of the ambient air on the first day is 63.75% with a maximum condition of 67% and the lowest air relative humidity condition is 60% and the average relative humidity of the air inside the device on the first day is 34.62% with a maximum condition of 37% and the lowest air relative humidity condition is 33%. The average relative humidity of the ambient air on the second day is 65.66% with a maximum condition of 69% and the lowest air relative humidity condition of 62% and the average relative humidity of the air insi de the device is 35.83% with a maximum condition of 38% and the lowest air relative humidity condition is 33%. The mathematical model of the relationship between water content and time on the bottom shelf is y = 0.6305e- 0.127x with R² = 0.972 on the middle shelf y = 0.6149e-0.118x with R² = 0.9875 on the top shelf y = 0.6434e-0.11x with R² = 0.9649. The drying rate on each shelf is different and changes occur every time because it depends on the mass of the material. The average drying rate on the lower shelf is 3.40%, the middle shelf is 3.31%, and the upper shelf is 3.21%. To reach a moisture content of 11-14% requires a total of 13 hours for 2 days.

 

 

Keywoards : sago drying, rack tipe solar dryer
RELEVANSI EVALUASI PENGELOLAAN DAERAH IRIGASI TALAWAAN MERAS PROVINSI SULAWESI UTARA
Authors: Anastasya Saki Friska , Kalesaran Leo , Rumambi David P.
Published: December 2023

AbstractThe objectives of this research were:: 1) to obtain information about evaluationin the Talawaan Meras Irrigation Area, 2) To evaluate the Management of IrrigationNetworks in the Talawaan Meras Irrigation Area. This research was carried outdirectly in the field and data collection was carried out using survey methods andinterviews with several selected respondents, as well as measurement/calculation ofthe characteristics of variables related to irrigation networks carried out directly onthe research object. The conclusions from this study are (1) The research location ofMS.3.Kr, which was originally 20 ha for rice fields, now the designation is no longerrice fields, but inland fisheries. (2) Measurement of water discharge in the secondarychannel at the MS.3.Kr location uses the float method, and the average dischargeobtained is 0.16 m^3/second. (3) The existing irrigation structures in the TalawaanMeras Irrigation Area are all in good condition and can function properly. (4) Theplanting season determined by the Agriculture Service is not in accordance with thefacts on the ground. (5) In the last 2 years, performance evaluation in the TalawaanMeras Irrigation Area on MS.3.Kr has not been carried out properly due to a lack ofoperational funds. Funds that should have been there have been focused on Covid-19funds. (6) There are 9 irrigation network officers in Talawaan Meras, but not all ofthem are active. At the MS.3.Kiri location, there is only one irrigation network officerwho has taken over all the tasks at that location.Keywords : evaluation, irrigation area management, Talawaan Meras