bluuebunny/crossref_metadata_2025 huggingface dataset:
Observed Regional Climate Variability during the Last 50 Years in Reindeer Herding Cooperatives of Finnish Fell Lapland
Authors: Lépy Élise , Pasanen Leena
Published: October 2017

In Finnish Lapland, reindeer herders’ activity is strongly dependent on the surrounding natural environment, which is directly exposed to environmental changes and climatic variations. By assessing whether there is any evidence of change in climate in Fell Lapland over the last 50 years, this paper attempts to link global climatic trends with local conditions and respond to the need of information at the local level. It aims at assessing the changes in temperature, precipitation and snow cover at a regional and local scale, as well as determining the climatic trends for the period 1960–2011. Statistical methods were used to conduct analyses of the regional homogeneity, the annual and seasonal variability, and the cold intensity. The results show that the regional climate is not homogeneous and differences exist between locations. Nevertheless, it can be concluded that, in general, a warming trend is discernible for the period 1960–2011, frost and thaw cycles slightly increase, and variations in mean temperatures are more important in the winter. Precipitation is more variable according to the site but, in general, precipitation is increasing with time, especially in the winter, and the snow cover does not seem to contain any discernible trend.
Evaluation of Using Mathematics Educational Software for the Learning of First-Year Primary School Students
Authors: Zaldívar-Colado Aníbal , Alvarado-Vázquez Ramón Ismael , Rubio-Patrón Diana Elizabeth
Published: October 2017

The use of educational software offers many advantages but may also become a frustrating experience for teachers and students that lack experience of its use. We presented an evaluation of the use of Maths educational software to support the learning of first-year primary students in the city of Mazatlan, Mexico. One of our reasons was to determine whether the use of Information and Communication Technologies (ICTs) would motivate students and make learning easier, more interesting and even fun. Three surveys were conducted wherein the following people participated: teachers who teach Maths in the first-year of primary school; managers of the computing facilities used in this study; and first-year primary students. Due to time constraints, the three surveys were only applied in three schools, in two shifts in each school. Overall, our study suggests three key aspects for learning to be improved through ICTs, namely: (1) learning activities should be designed considering the use of educational software; (2) learning materials and activities should include guiding material to facilitate learning; and (3) promote learning through play. We propose a few design principles for educational software to support learning better and more effectively.
Data-Driven ECG Denoising Techniques for Characterising Bipolar Lead Sets along the Left Arm in Wearable Long-Term Heart Rhythm Monitoring
Authors: Escalona Omar , Lynn William , Perpiñan Gilberto , McFrederick Louise , McEneaney David
Published: October 2017

Abnormal heart rhythms (arrhythmias) are a major cause of cardiovascular disease and death in Europe. Sudden cardiac death accounts for 50% of cardiac mortality in developed countries; ventricular tachycardia or ventricular fibrillation is the most common underlying arrhythmia. In the ambulatory population, atrial fibrillation is the most common arrhythmia and is associated with an increased risk of stroke and heart failure, particularly in an aging population. Early detection of arrhythmias allows appropriate intervention, reducing disability and death. However, in the early stages of disease arrhythmias may be transient, lasting only a few seconds, and are thus difficult to detect. This work addresses the problem of extracting the far-field heart electrogram signal from noise components, as recorded in bipolar leads along the left arm, using a data driven ECG (electrocardiogram) denoising algorithm based on ensemble empirical mode decomposition (EEMD) methods to enable continuous non-invasive monitoring of heart rhythm for long periods of time using a wrist or arm wearable device with advanced biopotential sensors. Performance assessment against a control denoising method of signal averaging (SA) was implemented in a pilot study with 34 clinical cases. EEMD was found to be a reliable, low latency, data-driven denoising technique with respect to the control SA method, achieving signal-to-noise ratio (SNR) enhancement to a standard closer to the SA control method, particularly on the upper arm-ECG bipolar leads. Furthermore, the SNR performance of the EEMD was improved when assisted with an FFT (fast Fourier transform ) thresholding algorithm (EEMD-fft).
Short-Circuit Fault Tolerant Control of a Wind Turbine Driven Induction Generator Based on Sliding Mode Observers
Authors: Sellami Takwa , Berriri Hanen , Jelassi Sana , Darcherif A Moumen , Mimouni M Faouzi
Published: October 2017

The installed energy production capacity of wind turbines is growing intensely on a global scale, making the reliability of wind turbine subsystems of greater significance. However, many faults like Inter-Turn Short-Circuit (ITSC) may affect the turbine generator and quickly lead to a decline in supplied power quality. In this framework, this paper proposes a Sliding Mode Observer (SMO)-based Fault Tolerant Control (FTC) scheme for Induction Generator (IG)-based variable-speed grid-connected wind turbines. First, the dynamic models of the wind turbine subsystems were developed. The control schemes were elaborated based on the Maximum Power Point Tracking (MPPT) method and Indirect Rotor Flux Oriented Control (IRFOC) method. The grid control was also established by regulating the active and reactive powers. The performance of the wind turbine system and the stability of injected power to the grid were hence analyzed under both healthy and faulty conditions. The robust developed SMO-based Fault Detection and Isolation (FDI) scheme was proved to be fast and efficient for ITSC detection and localization.Afterwards, SMO were involved in scheming the FTC technique. Accordingly, simulation results assert the efficacy of the proposed ITSC FTC method for variable-speed wind turbines with faulty IG in protecting the subsystems from damage and ensuring continuous connection of the wind turbine to the grid during ITSC faults, hence maintaining power quality.
A New Technique for Reducing Size of a WPT System Using Two-Loop Strongly-Resonant Inductors
Authors: Rozman Matjaz , Fernando Michael , Adebisi Bamidele , Rabie Khaled , Collins Tim , Kharel Rupak , Ikpehai Augustine
Published: October 2017

Mid-range resonant coupling-based high efficient wireless power transfer (WPT) techniques have gained substantial research interest due to the number of potential applications in many industries. This paper presents a novel design of a resonant two-loop WPT technique including the design, fabrication and preliminary results of this proposal. This new design employs a compensation inductor which is combined with the transmitter and receiver loops in order to significantly scale down the size of the transmitter and receiver coils. This can improve the portability of the WPT transmitters in practical systems. Moreover, the benefits of the system enhancement are not only limited to the lessened magnitude of the T X & R X , simultaneously both the weight and the bill of materials are also minimised. The proposed system also demonstrates compatibility with the conventional electronic components such as capacitors hence the development of the T X & R X is simplified. The proposed system performance has been validated using the similarities between the experimental and simulation results. The power efficiency of the prototype circuit is found to be 93%, which is close to the efficiency reached by the conventional design. However, the weight of the transmitter and receiver inductors is now reduced by 78%, while the length of these inductors is reduced by 80%.
Social Impacts of Solar Home Systems in Rural Areas: A Case Study in Bangladesh
Authors: Kabir Ehsanul , Kim Ki-Hyun , Szulejko Jan
Published: October 2017

As an alternative source of off-grid electric power, solar home systems (SHS) stand out above all other options (e.g., wind, hydro, geo-thermal, tidal systems) because of their wide-scale potential at latitudes less than 45° north or south of the Equator where daily solar irradiance is more constant throughout the year and where the bulk of the Third World’s population live. A questionnaire-based survey study was carried out in a rural area of Bangladesh to ascertain the impacts of SHSs on the lives of the rural population. The installation of an SHS was found to improve the comfort and living standard of rural dwellers. Easier access to TV, radio, cellphone, and the Internet helped the rural population become part of a more global culture. More attractive down-payment and installment package options will allow poor target groups to adopt this system. The standard of SHS components and after-sales service should be improved to ensure sustainably and popularity among the mass population for at least 10 years at minimal cost to the consumer. Our findings can also help policymakers adopt more SHS-friendly policies to further the interests of inhabitants of rural areas that are not connected to the grid.
Detecting Landscape Disturbance at the Nasca Lines Using SAR Data Collected from Airborne and Satellite Platforms
Authors: Comer Douglas , Chapman Bruce , Comer Jacob
Published: October 2017

We used synthetic aperture radar (SAR) data collected over Peru’s Lines and Geoglyphs of the Nasca and Palpa World Heritage Site to detect and measure landscape disturbance threatening world-renowned archaeological features and ecosystems. We employed algorithms to calculate correlations between pairs of SAR returns, collected at different times, and generate correlation images. Landscape disturbances even on the scale of pedestrian travel are discernible in correlation images generated from airborne, L-band SAR. Correlation images derived from C-band SAR data collected by the European Space Agency’s Sentinel-1 satellites also provide detailed landscape change information. Because the two Sentinel-1 satellites together have a repeat pass interval that can be as short as six days, products derived from their data can not only provide information on the location and degree of ground disturbance, but also identify a time window of about one to three weeks during which disturbance must have occurred. For Sentinel-1, this does not depend on collecting data in fine-beam modes, which generally sacrifice the size of the area covered for a higher spatial resolution. We also report on pixel value stretching for a visual analysis of SAR data, quantitative assessment of landscape disturbance, and statistical testing for significant landscape change.
How Can Humanities Interventions Promote Progress in the Environmental Sciences?
Authors: Kitch Sally
Published: October 2017

Environmental humanists make compelling arguments about the importance of the environmental humanities (EH) for discovering new ways to conceptualize and address the urgent challenges of the environmental crisis now confronting the planet. Many environmental scientists in a variety of fields are also committed to incorporating socio-cultural analyses in their work. Despite such intentions and rhetoric, however, and some humanists’ eagerness to incorporate science into their own work, “radical interdisciplinarity [across the humanities and sciences] is ... rare ... and does not have the impact one would hope for” (Holm et al. 2013, p. 32). This article discusses reasons for the gap between transdisciplinary intentions and the work being done in the environmental sciences. The article also describes a project designed to address that gap. Entitled “From Innovation to Progress: Addressing Hazards of the Sustainability Sciences”, the project encourages humanities interventions in problem definition, before any solution or action is chosen. Progress offers strategies for promoting expanded stakeholder engagement, enhancing understanding of power struggles and inequities that underlie problems and over-determine solutions, and designing multiple future scenarios based on alternative values, cultural practices and beliefs, and perspectives on power distribution and entitlement.
A Sightseeing Spot Recommendation System That Takes into Account the Change in Circumstances of Users
Authors: Mizutani Yuri , Yamamoto Kayoko
Published: October 2017

The present study aimed to design, develop, operate and evaluate a sightseeing spot recommendation system for urban sightseeing spots in order to support individual, as well as group sightseeing activities while taking into consideration the user’s needs, which can change according to the circumstances (each user’s important conditions and sightseeing unit). The system was developed by integrating Web-GIS (Geographic Information Systems), the pairing system, the evaluation system, as well as the recommendation system into a single system, and it was also connected with external SNS (Social Networking Services: Twitter and Facebook). Additionally, the system was operated for four weeks in the central part of Yokohama City in Kanagawa Prefecture, Japan, and the total number of users was 52. Based on the results of the web questionnaire survey, the usefulness of the system when sightseeing was high, and the recommendation function of sightseeing spots, which is an original function, has received mainly good ratings. From the results of the access analysis of users’ log data, it is evident that the system has been used by different types of devices, just as it was designed for, and that the system has been used according to the purpose of the present study, which is to support the sightseeing activities of users.
Assessing Spatial Accessibility of Public and Private Residential Aged Care Facilities: A Case Study in Wuhan, Central China
Authors: Cai Enxiang , Liu Yaolin , Jing Ying , Zhang Lei , Li Jiwei , Yin Chaohui
Published: October 2017

In the increasingly serious aging China, aged service is the provision of one of the most urgent and important public services to citizens, and private facilities has become an important service force with the aged service market opening in China. This study aims to explore the spatial variation in the accessibility of residential aged care facilities (RACFs) and compared the service capacity of public RACFs and private RACFs. It facilitates RACFs to be allocated rationally in the future and achieve the equalization of aged services. A village-level analysis of spatial access to public and private RACFs by the multi-catchment sizes Gaussian two-step floating catchment area (MCSG2SFCA) method was conducted through a case study in Wuhan City in Central China. The major results are as follows: (1) the accessibility of RACFs in urban areas is better than that in rural areas; (2) the public RACFs still dominate aged care services but the role of private RACFs is important as well; (3) in developed urban areas, the accessibility to private RACFs surpasses that of public ones, and the situation is opposite in rural areas; (4) the capacity of aged care services in Wuhan is not high, meanwhile there is remarkable regional disparity. The accessibility of RACFs in Wuhan is not satisfactory, and there is a significant gap between urban and rural areas. The private RACFs have significantly improved the urban capacity of aged care services, but the role in rural areas is still very weak.
Plasma miR-155, miR-203, and miR-205 are Biomarkers for Monitoring of Primary Cutaneous T-Cell Lymphomas
Authors: Dusílková Nina , Bašová Petra , Polívka Jindřich , Kodet Ondřej , Kulvait Vojtěch , Pešta Michal , Trněný Marek , Stopka Tomáš
Published: October 2017

Primary cutaneous T-cell lymphomas (CTCL) affect the skin and tend to transform and spread. CTCL involves primarily the Mycosis fungoides (MF) and more aggressive Sezary syndrome (SS). Oncogenic microRNAs (miRs) are stable epigenetic inhibitors often deregulated in the tumour and detectable as biomarkers in non-cellular fractions of peripheral blood. The tumour-specific expression of miR-155, miR-203, and miR-205 was shown to correctly diagnose CTCL. We herein asked whether these microRNAs can be used as plasma biomarkers for clinical CTCL monitoring. Patients with CTCL (n = 10) and controls with non-malignant conditions (n = 11) repeatedly donated plasma samples every ca. five months. MicroRNAs were detected in the plasma samples by specifically-primed RT-PCR followed by multivariate analyses of the miR expression dynamics. We herein established the plasma miR-classifier for detecting CTCL based on the miR-155 upregulation and miR-203/miR-205 downregulation with 100% specificity and 94% sensitivity. The 3-miR-score in the consecutive samples coincided with the clinical outcome of MF and SS patients such as the therapy response or changes in the clinical stage or tumor size. Quantitation of the selected microRNAs in plasma is a specific and straightforward approach for evaluating CTCL outcome representing, thus, a valuable tool for CTCL diagnostics and therapy response monitoring.
Diabetes-Induced Dysfunction of Mitochondria and Stem Cells in Skeletal Muscle and the Nervous System
Authors: Fujimaki Shin , Kuwabara Tomoko
Published: October 2017

Diabetes mellitus is one of the most common metabolic diseases spread all over the world, which results in hyperglycemia caused by the breakdown of insulin secretion or insulin action or both. Diabetes has been reported to disrupt the functions and dynamics of mitochondria, which play a fundamental role in regulating metabolic pathways and are crucial to maintain appropriate energy balance. Similar to mitochondria, the functions and the abilities of stem cells are attenuated under diabetic condition in several tissues. In recent years, several studies have suggested that the regulation of mitochondria functions and dynamics is critical for the precise differentiation of stem cells. Importantly, physical exercise is very useful for preventing the diabetic alteration by improving the functions of both mitochondria and stem cells. In the present review, we provide an overview of the diabetic alterations of mitochondria and stem cells and the preventive effects of physical exercise on diabetes, focused on skeletal muscle and the nervous system. We propose physical exercise as a countermeasure for the dysfunction of mitochondria and stem cells in several target tissues under diabetes complication and to improve the physiological function of patients with diabetes, resulting in their quality of life being maintained.
Interaction between Rho GTPases and 14-3-3 Proteins
Authors: Brandwein Daniel , Wang Zhixiang
Published: October 2017

The Rho GTPase family accounts for as many as 20 members. Among them, the archetypes RhoA, Rac1, and Cdc42 have been the most well-characterized. Like all members of the small GTPases superfamily, Rho proteins act as molecular switches to control cellular processes by cycling between active, GTP-bound and inactive, GDP-bound states. The 14-3-3 family proteins comprise seven isoforms. They exist as dimers (homo- or hetero-dimer) in cells. They function by binding to Ser/Thr phosphorylated intracellular proteins, which alters the conformation, activity, and subcellular localization of their binding partners. Both 14-3-3 proteins and Rho GTPases regulate cell cytoskeleton remodeling and cell migration, which suggests a possible interaction between the signaling pathways regulated by these two groups of proteins. Indeed, more and more emerging evidence indicates the mutual regulation of these two signaling pathways. There have been many documented reviews of 14-3-3 protein and Rac1 separately, but there is no review regarding the interaction and mutual regulation of these two groups of proteins. Thus, in this article we thoroughly review all the reported interactions between the signaling pathways regulated by 14-3-3 proteins and Rho GTPases (mostly Rac1).
The Role of the S40 Gene Family in Leaf Senescence
Authors: Jehanzeb Muhammad , Zheng Xiangzi , Miao Ying
Published: October 2017

Senescence affect different traits of plants, such as the ripening of fruit, number, quality and timing of seed maturation. While senescence is induced by age, growth hormones and different environmental stresses, a highly organized genetic mechanism related to substantial changes in gene expression regulates the process. Only a few genes associated to senescence have been identified in crop plants despite the vital significance of senescence for crop yield. The S40 gene family has been shown to play a role in leaf senescence. The barley HvS40 gene is one of the senescence marker genes which shows expression during age-dependent as well as dark-induced senescence. Like barley HvS40, the Arabidopsis AtS40-3 gene is also induced during natural senescence as well as in response to treatment with abscisic acid, salicylic acid, darkness and pathogen attack. It is speculated that rice OsS40 has a similar function in the leaf senescence of rice.
TODIM Method for Single-Valued Neutrosophic Multiple Attribute Decision Making
Authors: Xu Dong-Sheng , Wei Cun , Wei Gui-Wu
Published: October 2017

Recently, the TODIM has been used to solve multiple attribute decision making (MADM) problems. The single-valued neutrosophic sets (SVNSs) are useful tools to depict the uncertainty of the MADM. In this paper, we will extend the TODIM method to the MADM with the single-valued neutrosophic numbers (SVNNs). Firstly, the definition, comparison, and distance of SVNNs are briefly presented, and the steps of the classical TODIM method for MADM problems are introduced. Then, the extended classical TODIM method is proposed to deal with MADM problems with the SVNNs, and its significant characteristic is that it can fully consider the decision makers’ bounded rationality which is a real action in decision making. Furthermore, we extend the proposed model to interval neutrosophic sets (INSs). Finally, a numerical example is proposed.
Investigation of the Thermodynamic Properties of Surface Ceria and Ceria–Zirconia Solid Solution Films Prepared by Atomic Layer Deposition on Al2O3
Authors: Onn Tzia , Mao Xinyu , Lin Chao , Wang Cong , Gorte Raymond
Published: October 2017

The properties of 20 wt % CeO2 and 21 wt % Ce0.5Zr0.5O2 films, deposited onto a γ-Al2O3 by Atomic Layer Deposition (ALD), were compared to bulk Ce0.5Zr0.5O2 and γ-Al2O3-supported samples on which 20 wt % CeO2 or 21 wt % CeO2–ZrO2 were deposited by impregnation. Following calcination to 1073 K, the ALD-prepared catalysts showed much lower XRD peak intensities, implying that these samples existed as thin films, rather than larger crystallites. Following the addition of 1 wt % Pd to each of the supports, the ALD-prepared samples exhibited much higher rates for CO oxidation due to better interfacial contact between the Pd and ceria-containing phases. The redox properties of the ALD samples and bulk Ce0.5Zr0.5O2 were measured by determining the oxidation state of the ceria as a function of the H2:H2O ratio using flow titration and coulometric titration. The 20 wt % CeO2 ALD film exhibited similar thermodynamics to that measured previously for a sample prepared by impregnation. However, the sample with 21 wt % Ce0.5Zr0.5O2 on γ-Al2O3 reduced at a much higher P O 2 and showed evidence for transition between the Ce0.5Zr0.5O2 and Ce0.5Zr0.5O1.75 phases.
Long-Term Benefits of Adapted Physical Activity on Upper Limb Performance and Quality of Life in Breast Cancer Survivors
Authors: Mirandola Daniela , Monaci Marco , Miccinesi Guido , Ventura Leonardo , Muraca Maria , Casini Elisa , Sgambati Eleonora , Manetti Mirko , Marini Mirca
Published: October 2017

Current evidence suggests that physical activity interventions can improve quality of life, fitness, and strength, reducing depression and fatigue in breast cancer survivors. However, in the long-term many survivors are insufficiently active. Here, the possible long-term benefits of a specific adapted physical activity (APA) intervention on upper limb functional performance and quality of life in breast cancer survivors were investigated. For this purpose, fifteen survivors were assessed by fitness tests (shoulder-arm mobility, range of motion, back flexibility) at the baseline and at eight weeks post-APA intervention. Quality of life and surgical shoulder and back pain intensity were evaluated by Short Form-12 and numerical rating scale questionnaires, respectively. Five participants, who continued to follow the APA protocol over time, were again evaluated after two years and compared to either five women who were inactive or five others who practiced general physical activity after ending the eight-week APA protocol. Shoulder-arm mobility and self-reported questionnaire data revealed the maintenance and/or improvement of the achieved benefits two years after the APA intervention. Our findings suggest that the long-term practice of APA tailored to individual characteristics should be recommended to breast cancer survivors in order to preserve quality of life and fitness.
Personomics: The Missing Link in the Evolution from Precision Medicine to Personalized Medicine
Authors: Ziegelstein Roy
Published: October 2017

Clinical practice guidelines have been developed for many common conditions based on data from randomized controlled trials. When medicine is informed solely by clinical practice guidelines, however, the patient is not treated as an individual, but rather a member of a group. Precision medicine, as defined herein, characterizes unique biological characteristics of the individual or of specimens obtained from an individual to tailor diagnostics and therapeutics to a specific patient. These unique biological characteristics are defined by the tools of precision medicine: genomics, proteomics, metabolomics, epigenomics, pharmacogenomics, and other “-omics.” Personalized medicine, as defined herein, uses additional information about the individual derived from knowing the patient as a person. These unique personal characteristics are defined by tools known as personomics which takes into account an individual’s personality, preferences, values, goals, health beliefs, social support network, financial resources, and unique life circumstances that affect how and when a given health condition will manifest in that person and how that condition will respond to treatment. In this paradigm, precision medicine may be considered a necessary step in the evolution of medical care to personalized medicine, with personomics as the missing link.
Molecular Dynamics Simulation of Crack Propagation in Nanoscale Polycrystal Nickel Based on Different Strain Rates
Authors: Zhang Yanqiu , Jiang Shuyong
Published: October 2017

Based on the strain rates of 2 × 108 s−1 and 2 × 1010 s−1, molecular dynamics simulation was conducted so as to study mechanisms of crack propagation in nanoscale polycrystal nickel. The strain rate has an important effect on the mechanism of crack propagation in nanoscale polycrystal nickel. In the case of a higher strain rate, local non-3D-crystalline atoms are induced and Lomer-Cottrell locks are formed, which plays a critical role in crack initiation and propagation. Orientation difference between adjacent grains leads to the slipping of dislocations along the different directions, which results in the initiation of a void near the triple junction of grain boundaries and further contributes to accelerating the crack propagation.
A Two-Step Bioconversion Process for Canolol Production from Rapeseed Meal Combining an Aspergillus niger Feruloyl Esterase and the Fungus Neolentinus lepideus
Authors: Odinot Elise , Fine Frédéric , Sigoillot Jean-Claude , Navarro David , Laguna Oscar , Bisotto Alexandra , Peyronnet Corinne , Ginies Christian , Lecomte Jérôme , Faulds Craig , Lomascolo Anne
Published: October 2017

Rapeseed meal is a cheap and abundant raw material, particularly rich in phenolic compounds of biotechnological interest. In this study, we developed a two-step bioconversion process of naturally occurring sinapic acid (4-hydroxy-3,5-dimethoxycinnamic acid) from rapeseed meal into canolol by combining the complementary potentialities of two filamentous fungi, the micromycete Aspergillus niger and the basidiomycete Neolentinus lepideus. Canolol could display numerous industrial applications because of its high antioxidant, antimutagenic and anticarcinogenic properties. In the first step of the process, the use of the enzyme feruloyl esterase type-A (named AnFaeA) produced with the recombinant strain A. niger BRFM451 made it possible to release free sinapic acid from the raw meal by hydrolysing the conjugated forms of sinapic acid in the meal (mainly sinapine and glucopyranosyl sinapate). An amount of 39 nkat AnFaeA per gram of raw meal, at 55 °C and pH 5, led to the recovery of 6.6 to 7.4 mg of free sinapic acid per gram raw meal, which corresponded to a global hydrolysis yield of 68 to 76% and a 100% hydrolysis of sinapine. Then, the XAD2 adsorbent (a styrene and divinylbenzene copolymer resin), used at pH 4, enabled the efficient recovery of the released sinapic acid, and its concentration after elution with ethanol. In the second step, 3-day-old submerged cultures of the strain N. lepideus BRFM15 were supplied with the recovered sinapic acid as the substrate of bioconversion into canolol by a non-oxidative decarboxylation pathway. Canolol production reached 1.3 g/L with a molar yield of bioconversion of 80% and a productivity of 100 mg/L day. The same XAD2 resin, when used at pH 7, allowed the recovery and purification of canolol from the culture broth of N. lepideus. The two-step process used mild conditions compatible with green chemistry.
Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years
Authors: Sinokrot Hanadi , Smerat Tasneem , Najjar Anas , Karaman Rafik
Published: October 2017

Background: Poor pharmacokinetic profiles and resistance are the main two drawbacks from which currently used antiviral agents suffer, thus make them excellent targets for research, especially in the presence of viral pandemics such as HIV and hepatitis C. Methods: The strategies employed in the studies covered in this review were sorted by the type of drug synthesized into ester prodrugs, targeted delivery prodrugs, macromolecular prodrugs, other nucleoside conjugates, and non-nucleoside drugs. Results: Utilizing the ester prodrug approach a novel isopropyl ester prodrug was found to be potent HIV integrase inhibitor. Further, employing the targeted delivery prodrug zanamivir and valine ester prodrug was made and shown a sole delivery of zanamivir. Additionally, VivaGel, a dendrimer macromolecular prodrug, was found to be very efficient and is now undergoing clinical trials. Conclusions: Of all the strategies employed (ester, targeted delivery, macromolecular, protides and nucleoside analogues, and non-nucleoside analogues prodrugs), the most promising are nucleoside analogues and macromolecular prodrugs. The macromolecular prodrug VivaGel works by two mechanisms: envelope mediated and receptor mediated disruption. Nucleotide analogues have witnessed productive era in the recent past few years. The era of non-interferon based treatment of hepatitis (through direct inhibitors of NS5A) has dawned.
A Low-Cost, Formaldehyde-Free and High Flame Retardancy Wood Adhesive from Inorganic Adhesives: Properties and Performance
Authors: Jin Shicun , Li Kuang , Li Jianzhang , Chen Hui
Published: October 2017

Wood composites used in indoor living environments often pose formaldehyde emission and fire hazard problems. In this study, magnesium oxychloride cement-based (MOC) inorganic adhesives are presented as an effective and sustainable binder for plywood applications. The phase composition, microstructure, and thermal stability of the adhesives prepared with different ratios of MgO/MgCl2 were investigated. In addition, the dry and wet shear strength and the combustion behavior of the plywood were also examined. The results indicated that the limiting oxygen index (LOI) values of the plywood bonded by the MOC adhesives were higher than those of the plywood bonded by urea-formaldehyde resin. The active MgO/MgCl2 molar ratio of 7 was the optimal ratio for the dry and wet shear strength of the plywood with values of 1.02 and 0.88 MPa, respectively, which meet the interior use panel (Type II plywood) requirements. These improvements were ascribed to the increasing ratio of MgO/MgCl2 that facilitated the formation of an excellent microstructure. Meanwhile, the continuous hydration phase strengthened the interaction between the MOC adhesive and the wood. With these improved properties, MOC adhesive is expected to be widely used for industrial applications in plywood fabrication.
Characterization and Performance of Soy-Based Adhesives Cured with Epoxy Resin
Authors: Chen Nairong , Zheng Peitao , Zeng Qinzhi , Lin Qiaojia , Rao Jiuping
Published: October 2017

Soy-based adhesives have attracted much attention recently because they are environmentally safe, low cost, and readily available. To improve the gluability and water resistance of soy-based adhesives, we prepared an enzyme-treated soy-based adhesive modified with an epoxy resin. We investigated the wet shear strength of plywood bonded with the modified adhesive using the boiling-water test. Fourier transformed infrared spectroscopy (FTIR) and 1H nuclear magnetic resonance analysis were used to characterize the reaction between epoxy groups and –NH2 groups in the modified soy-based adhesives. FTIR analysis confirmed the cross-linking structure in the cured adhesives. Viscosity and the solid content of soy-based adhesives gradually increased with the increasing amount of epoxy resin, but had little effect on its operability. Wet shear strength of plywood samples increased as the amount of epoxy resin was increased, whereas the inverse trend was observed regarding the water absorption of cured adhesives. Compared to an unmodified adhesive, the addition of 30% of epoxy resin increased the wet shear strength of plywood samples by 58.3% (0.95 MPa), meeting the requirement of the Chinese National Standard for exterior plywood. Differential scanning calorimetry and thermogravimetric analysis showed the improved thermostability of the cured adhesives after curing at 160 °C. These results suggest that epoxy resin could effectively improve the performance of enzyme-treated soy-based adhesives, which might provide a new option for the preparation of soy-based adhesives with high gluability and water resistance.
Mass Spectrometric Studies of Apolipoprotein Proteoforms and Their Role in Lipid Metabolism and Type 2 Diabetes
Authors: Nedelkov Dobrin
Published: October 2017

Apolipoproteins function as structural components of lipoprotein particles, cofactors for enzymes, and ligands for cell-surface receptors. Most of the apoliporoteins exhibit proteoforms, arising from single nucleotide polymorphisms (SNPs) and post-translational modifications such as glycosylation, oxidation, and sequence truncations. Reviewed here are recent studies correlating apolipoproteins proteoforms with the specific clinical measures of lipid metabolism and cardiometabolic risk. Targeted mass spectrometric immunoassays toward apolipoproteins A-I, A-II, and C-III were applied on large cross-sectional and longitudinal clinical cohorts. Several correlations were observed, including greater apolipoprotein A-I and A-II oxidation in patients with diabetes and cardiovascular disease, and a divergent apoC-III proteoforms association with plasma triglycerides, indicating significant differences in the metabolism of the individual apoC-III proteoforms. These are the first studies of their kind, correlating specific proteoforms with clinical measures in order to determine their utility as potential clinical biomarkers for disease diagnosis, risk stratification, and therapy decisions. Such studies provide the impetus for the further development and clinical translation of MS-based protein tests.
“He Who Enters the Bath-House Utters Two Blessings”: On the Evolvement and Decline of an Ancient Jewish Prayer
Authors: Shemesh Abraham
Published: October 2017

One of the improvements introduced by the Romans was the public bath-house. This article discusses the formation of Jewish prayers, which were composed during the early rabbinic period, following the dangers of the public baths. Sages from late antiquity published two prayers: Before entering to the bathhouse, the bather has to pray for his safety, and after leaving the bath-house he has to thank Gd for not having suffered harm. The dangers of the bathhouse were deemed to include: Weakness, fainting or dehydration due to the heat of the bathhouse; Legs injury of the bathers due to the heat of the warm floor; Dental damage; Sliding on the wet floor; Fear of death due to collapse of the hypocaust. Due to changes in the bath-house in the modern era; these prayers lost their relevance up to a point; or at any rate; they were no longer prescribed or recorded in practice. Bathhouse heaters were no longer located in the hypocaust; and were rather only located close to the wall of the upper room. Hence; falling into the hot lower space was irrelevant. Following the introduction of domestic baths; these prayers have completely vanished.
The Spatial and Temporal Distributions of Absorbing Aerosols over East Asia
Authors: Kang Litai , Chen Siyu , Huang Jianping , Zhao Shuman , Ma Xiaojun , Yuan Tiangang , Zhang Xiaorui , Xie Tingting
Published: October 2017

Absorbing aerosols can strongly absorb solar radiation and have a profound impact on the global and regional climate. Black carbon (BC), organic carbon (OC) and dust are three major types of absorbing aerosols. In order to deepen the overall understanding of absorbing aerosols over East Asia and provide a basis for further investigation of its role in enhanced warming in drylands, the spatial-temporal distribution of absorbing aerosols over East Asia for the period of 2005–2016 was investigated based on the Ozone Monitoring Instrument (OMI) satellite retrievals. Overall, high values of Aerosol Absorption Optical Depth (AAOD) mainly distribute near dust sources as well as BC and OC sources. AAOD reaches its maximum during spring over East Asia as a result of dust activity and biomass burning. Single-scattering albedo (SSA) is comparatively high (>0.96) in the most part of East Asia in the summer, indicating the dominance of aerosol scattering. Hyper-arid regions have the highest Aerosol Optical Depth (AOD) and AAOD among the five climatic regions, with springtime values up to 0.72 and 0.04, respectively. Humid and sub-humid regions have relatively high AOD and AAOD during the spring and winter and the highest SSA during the summer. AAOD in some areas shows significant upward trends, which is likely due to the increase of BC and OC emission. SSA shows overall downward trends, indicating the enhancement of the aerosol absorption. Analysis of emission inventory and dust index data shows that BC and OC emissions mainly come from the humid regions, while dust sources mainly distribute in drylands.
Evaluating Fourier Cross-Correlation Sub-Pixel Registration in Landsat Images
Authors: Almonacid-Caballer Jaime , Pardo-Pascual Josep , Ruiz Luis
Published: October 2017

Multi-temporal analysis is one of the main applications of remote sensing, and Landsat imagery has been one of the main resources for many years. However, the moderate spatial resolution (30 m) restricts their use for high precision applications. In this paper, we simulate Landsat scenes to evaluate, by means of an exhaustive number of tests, a subpixel registration process based on phase correlation and the upsampling of the Fourier transform. From a high resolution image (0.5 m), two sets of 121 synthetic images of fixed translations are created to simulate Landsat scenes (30 m). In this sense, the use of the point spread function (PSF) of the Landsat TM (Thematic Mapper) sensor in the downsampling process improves the results compared to those obtained by simple averaging. In the process of obtaining sub-pixel accuracy by upsampling the cross correlation matrix by a certain factor, the limit of improvement is achieved at 0.1 pixels. We show that image size affects the cross correlation results, but for images equal or larger than 100 × 100 pixels similar accuracies are expected. The large dataset used in the tests allows us to describe the intra-pixel distribution of the errors obtained in the registration process and how they follow a waveform instead of random/stochastic behavior. The amplitude of this waveform, representing the highest expected error, is estimated at 1.88 m. Finally, a validation test is performed over a set of sub-pixel shorelines obtained from actual Landsat-5 TM, Landsat-7 ETM+ (Enhanced Thematic Mapper Plus) and Landsat-8 OLI (Operation Land Imager) scenes. The evaluation of the shoreline accuracy with respect to permanent seawalls, before and after the registration, shows the importance of the registering process and serves as a non-synthetic validation test that reinforce previous results.
Low Cost Lab on Chip for the Colorimetric Detection of Nitrate in Mineral Water Products
Authors: Khanfar Mohammad , Al-Faqheri Wisam , Al-Halhouli Ala’aldeen
Published: October 2017

The diagnostics of health status and the quality of drinking water are among the most important United Nations sustainable development goals. However, in certain areas, wars and instability have left millions of people setting in refugee camps and dangerous regions where infrastructures are lacking and rapid diagnostics of water quality and medical status are critical. In this work, microfluidic testing chips and photometric setups are developed in cheap and portable way to detect nitrate concentrations in water. The performed test is designed to work according to the Griess procedure. Moreover, to make it simple and usable in areas of low resource settings, commercially available Arduino mega and liquid crystal display (LCD) shield are utilized to process and display results, respectively. For evaluation purposes, different local products of tap water, bottled drinking water, and home-filter treated water samples were tested using the developed setup. A calibration curve with coefficient of determination (R2) of 0.98 was obtained when absorbance of the prepared standard solutions was measured as a function of the concentrations. In conclusion, this is the first step towards a compact, portable, and reliable system for nitrate detection in water for point-of-care applications.
Relative Humidity Sensor Based on No-Core Fiber Coated by Agarose-Gel Film
Authors: Xu Wei , Shi Jia , Yang Xianchao , Xu Degang , Rong Feng , Zhao Junfa , Yao Jianquan
Published: October 2017

A relative humidity (RH) sensor based on single-mode–no-core–single-mode fiber (SNCS) structure is proposed and experimentally demonstrated. The agarose gel is coated on the no-core fiber (NCF) as the cladding, and multimode interference (MMI) occurs in the SNCS structure. The transmission spectrum of the sensor is modulated at different ambient relative humidities due to the tunable refractive index property of the agarose gel film. The relative humidity can be measured by the wavelength shift and intensity variation of the dip in the transmission spectra. The humidity response of the sensors, coated with different concentrations and coating numbers of the agarose solution, were experimentally investigated. The wavelength and intensity sensitivity is obtained as −149 pm/%RH and −0.075 dB/%RH in the range of 30% RH to 75% RH, respectively. The rise and fall time is tested to be 4.8 s and 7.1 s, respectively. The proposed sensor has a great potential in real-time RH monitoring.
Nighttime Foreground Pedestrian Detection Based on Three-Dimensional Voxel Surface Model
Authors: Li Jing , Zhang Fangbing , Wei Lisong , Yang Tao , Lu Zhaoyang
Published: October 2017

Pedestrian detection is among the most frequently-used preprocessing tasks in many surveillance application fields, from low-level people counting to high-level scene understanding. Even though many approaches perform well in the daytime with sufficient illumination, pedestrian detection at night is still a critical and challenging problem for video surveillance systems. To respond to this need, in this paper, we provide an affordable solution with a near-infrared stereo network camera, as well as a novel three-dimensional foreground pedestrian detection model. Specifically, instead of using an expensive thermal camera, we build a near-infrared stereo vision system with two calibrated network cameras and near-infrared lamps. The core of the system is a novel voxel surface model, which is able to estimate the dynamic changes of three-dimensional geometric information of the surveillance scene and to segment and locate foreground pedestrians in real time. A free update policy for unknown points is designed for model updating, and the extracted shadow of the pedestrian is adopted to remove foreground false alarms. To evaluate the performance of the proposed model, the system is deployed in several nighttime surveillance scenes. Experimental results demonstrate that our method is capable of nighttime pedestrian segmentation and detection in real time under heavy occlusion. In addition, the qualitative and quantitative comparison results show that our work outperforms classical background subtraction approaches and a recent RGB-D method, as well as achieving comparable performance with the state-of-the-art deep learning pedestrian detection method even with a much lower hardware cost.
A Low Cost Sensors Approach for Accurate Vehicle Localization and Autonomous Driving Application
Authors: Vivacqua Rafael , Vassallo Raquel , Martins Felipe
Published: October 2017

Autonomous driving in public roads requires precise localization within the range of few centimeters. Even the best current precise localization system based on the Global Navigation Satellite System (GNSS) can not always reach this level of precision, especially in an urban environment, where the signal is disturbed by surrounding buildings and artifacts. Laser range finder and stereo vision have been successfully used for obstacle detection, mapping and localization to solve the autonomous driving problem. Unfortunately, Light Detection and Ranging (LIDARs) are very expensive sensors and stereo vision requires powerful dedicated hardware to process the cameras information. In this context, this article presents a low-cost architecture of sensors and data fusion algorithm capable of autonomous driving in narrow two-way roads. Our approach exploits a combination of a short-range visual lane marking detector and a dead reckoning system to build a long and precise perception of the lane markings in the vehicle’s backwards. This information is used to localize the vehicle in a map, that also contains the reference trajectory for autonomous driving. Experimental results show the successful application of the proposed system on a real autonomous driving situation.