bluuebunny/crossref_metadata_2025 huggingface dataset:
The origins of hospital culture. Solidarity in the work in hospital is medicine for man
Authors: Brera Giuseppe R.
Published: September 2024

Hospital solidarity is born, develops and ends in love, or at least that is how it should be. It is a strange love, the one that brings Hospitals to life, perhaps paradoxical and anachronistic if one wants to generalise in a rather superficial way, because it finds its object and subject in pain and suffering. It seems illogical that Hospitals can find their meaning in pain and suffering, it seems so far from ‘common sense’ that pain and suffering can generate and not remain occasional and final episodes of random and indeterminate existences.
Psychological and psychosomatic aspects of the caesarean section experience
Authors: Plotti G. , Pieroni A.
Published: September 2024

Caesarean section is the only obstetric operation that, by avoiding the vaginal route, allows the fetus to be quickly extracted via the abdominal route. Its performance is therefore justified when there is an indication for rapid delivery or when the vaginal route is contraindicated because the necessary conditions are not met.
Bioethical aspects of human in vitro fertilisation
Authors: Di Giovanni Alberto
Published: September 2024

My subject is human fertilisation ‘in vitro’ (acronym: IVF), extracorporeal therefore, not the artificial insemination of the husband's semen, carried out in the woman's womb (to complete the conjugal act: artificial insemination in the improper sense; while that outside the conjugal act is called artificial insemination in the proper sense, homologous; heterologous insemination, if with semen from a ‘donor’ outside the couple).
Der Weltbürger aus Königsberg: Immanuel Kant heute. Person und Werk
Authors: Pozzo Riccardo
Published: September 2024

One of the West’s greatest thinkers was born 300 years ago on 22 April 1724: Immanuel Kant. This circumstance is reason enough to consider what this philosopher – a high point and turning point of the European Enlightenment and one of the most important intellectual personalities of mankind – has to say to us today. There is no doubt that Kant made an outstanding contribution to the intellectual history of the human species, i.e., to the global history of ideas. But this also applies to Thales, Pythagoras and Archimedes, to Hippocrates and Galen, to Galileo, Copernicus, Kepler and Newton as well as many other mathematicians, naturalists, engineers and physicians. While the ideas of the latter group were overtaken by subsequent researchers after some time, this is not the case with Kant. This book argues that Kant’s philosophy was certainly of revolutionary significance for his time; however, it cannot be considered obsolete now. Kant’s impact today goes well beyond having intellectual-historical value.
Assessment of “Incompleteness” and “Not-just-right Experiences” in Patients of Obsessive-compulsive Disorders: A Cross-sectional Study
Authors: Shah Priyanka Suketu , Prajapati Aalapi Baldev , Parikh Aatman Nimesh , Vibhakar Gautam Rajendra , Desai Jayana , Patel Dharmesh S.
Published: September 2024

Introduction:

Subjects suffering from obsessive-compulsive disorder (OCD) often experience distress when they have sensations that do not give satisfaction, leading them to perform actions to eliminate them. These sensations, commonly referred to as not-just-right experiences (NJREs), significantly disrupt the daily functioning of individuals with OCD. This study explores the intricate relationship between feelings of incompleteness and the occurrence of NJREs in patients diagnosed with OCD.

Methods:

A cross-sectional study was conducted among patients diagnosed with OCD according to the Diagnostic and Statistical Manual-5. Severity was measured using the Yale-Brown Obsessive-Compulsive Scale. They were then assessed for NJREs using ‘‘not just right experiences-questionnaire- revised’’ (NJRE-Q-R). Depression was assessed using the Hamilton Depression Rating Scale (HAM-D) questionnaire. The statistical analysis of study data was done, and the analysis of variance test was utilized to assess the correlation of the severity of OCD and depression with NJREs.

Results:

The mean NJRE score (21.5) was statistically significantly higher in severe OCD. Patients with severe symptoms of OCD also experienced NJREs that were severe in intensity and associated with immediate and delayed distress. Furthermore, a positive correlation between NJREs and HAM-D scores was found suggesting evidence of depressive features in patients suffering from NJREs.

Conclusion:

OCD symptoms are significantly associated with NJREs. Our study indicates the need for screening of NJREs not only in patients suffering from OCD but also among those having depression. This would further help in the development of specialized intervention techniques to prevent the progress of obsessive-compulsive symptoms and its associated comorbidities.
BACE1 inhibitors: A promising therapeutic approach for the management of Alzheimer’s disease
Authors: Arya Richa , Jain Smita , Paliwal Sarvesh , Madan Kirtika , Sharma Swapnil , Mishra Achal , Tiwari Prashant , Kadiri Sunil Kumar
Published: September 2024

Alzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta (Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β-secretase, also known as β-site amyloid precursor protein cleaving enzyme 1 (BACE1), plays a crucial role in generating Aβ peptides. With no targeted therapy available for Alzheimer’s disease, inhibiting BACE1 aspartic protease has emerged as a primary treatment target. Since 1999, compounds demonstrating potential binding to the BACE1 receptor have advanced to human trials. Structural optimization of synthetically derived compounds, coupled with computational approaches, has offered valuable insights for developing highly selective leads with drug-like properties. This review highlights pivotal studies on the design and development of BACE1 inhibitors as anti-Alzheimer’s disease agents. It summarizes computational methods employed in facilitating drug discovery for potential BACE1 inhibitors and provides an update on their clinical status, indicating future directions for novel BACE1 inhibitors. The promising clinical results of Elenbecestat (E-2609) catalyze the development of effective, selective BACE1 inhibitors in the future.
Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice
Authors: Gavhane Swapnil , Gawli Chandrakant , Kumar Sachin , Das Biswajit , Marathe Gayatri , Patil Vishal S. , Patel Harun M. , Bommanahalli Basavaraj , Kundu Chanakya Nath , Patil Chandragouda R.
Published: September 2024

Objective:

To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis (IPF) and to explore its underlying mechanisms using network pharmacology.

Methods:

IPF was induced in C57BL/6 mice by a single intratracheal instillation of bleomycin (5 mg/kg). Trigonelline was administered at doses of 25, 50, and 100 mg/kg/day orally from the 2nd day post-bleomycin induction up to the 14th day. In IPF-induced mice, lung coefficient, immune cell infiltration in bronchoalveolar lavage fluid, and oxidative stress were measured. Histological alterations in lung tissues were also assessed. Moreover, network pharmacology approach was conducted to reveal molecular interactions of bleomycin and trigonelline with targets of IPF.

Results:

Trigonelline treatment reduced bleomycin-induced oxidative stress and immune cell infiltration, and mitigated physiological changes in the lung tissues of mice. Moreover, trigonelline alleviated bleomycin-induced histological alterations in lung tissues. Network pharmacology analysis showed that bleomycin and trigonelline interacted with IPF targets, such as NFKB1, HDAC2, HIF1A, and TLR4.

Conclusions:

The interaction of trigonelline with key IPF targets and its ameliorative effects on lung damage and oxidative stress highlight its potential in treating IPF. It may be considered an antifibrotic agent for further clinical development.
Efficacy of scrambler therapy in chronic neuropathic pain: pairwise and dose-response meta-analysis
Authors: Mohamed Mohamed S. I. , Alkahlout Lama , Elgamal Salma , Mohiuddin Amna , Al-sayed Talal , Al-Marri Hamad , Zahid Fatima , Martínez-Magallanes Daniela , Fregni Felipe , Doi Suhail A. R. , Abdallah Abdallah M. , Musa Omran A.H. , Khan Muhammad Naseem , Babu Giridhara R.
Published: September 2024

Chronic neuropathic pain (CNP) affects 7% of the world’s population and is challenging to control since existing medications are inadequate and have negative effects. Electrocutaneous devices, such as scrambler therapy (ST), have emerged as a possible option and have shown promising results in multiple randomized controlled trials (RCTs). However, the long-term efficacy of ST remains unknown. We aimed to evaluate the efficacy of ST in CNP reduction over time. We used the data sources including PubMed, Embase, Scopus, and Cochrane Central Register of Controlled Trials from inception to September 2023. Five placebo and three routine-care controlled RCTs were selected among the screened abstracts. Two authors independently extracted the data. Data was pooled using a model under the common parameters assumption. The studies were evaluated for methodological quality using the MethodologicAl STandard for Epidemiological Research (MASTER) scale. The primary outcome measure was pain reduction; pain was converted to a common 0 to 10 scale, and a weighted mean difference of more than 2 points on a 10-point pain scale was considered clinically important. Eight RCTs that evaluated the effect of ST on CNP were included, with a total sample size of 350 participants. None of the participants withdrew in all these trials owing to adverse events or lack of efficacy. There was high-quality evidence that ST reduced pain in the short term, with a mean difference of –3 points. The dose-response meta-analysis demonstrated a significant reduction in pain scores post-treatment, with a peak reduction at day 40. The effect of ST remained below the baseline values for 90 days, although with limited certainty. This study is the first dose-response meta-analysis to assess the duration of efficacy of ST in the treatment of CNP. The results demonstrated a clinically significant and more sustained reduction in pain created by ST compared to conventional treatments. Our findings indicate that ST could be used as a safe and effective alternative for managing CNP.
Matrix metalloproteinase 9 level changes in gingival crevicular fluid samples of teeth with acute and chronic apical periodontitis
Authors: Azimi Nozhan , Khanmohammadi Mohammad Mahdi , Mesbahian Sarvin , Khatibzadeh Mozhgan , Vatanpour Mehdi , Moshari Amirabbas
Published: September 2024

Background:

This study investigates the influence of dental pulp and periapical status on inflammatory mediators, particularly matrix metalloproteinases (MMPs), which contribute to tissue destruction around the teeth and the development of periodontitis. This study aimed to compare MMP-9 levels in the gingival crevicular fluid (GCF) between the cases of acute apical periodontitis, chronic apical periodontitis, and healthy controls before and after root canal treatment (RCT).

Materials and Methods:

This prospective, cohort study involved 19 samples each of acute and chronic periodontitis cases, both before and after RCT, along with 18 samples from healthy control teeth. The samples were collected from the GCF using paper cones. After 2 weeks of RCT, the process was repeated. MMP-9 levels were measured using the enzyme-linked immunosorbent assay technique. Statistical analysis was performed using the paired t-test and analysis of variance test and the significance level was set at < 0.05.

Results:

Before treatment, there was no significant difference in MMP-9 levels between the healthy (0.476 μg/μL) and acute (0.48 μg/μL) groups; however, significant differences were observed between the healthy and chronic (0.534 μg/μL) groups. In addition, MMP-9 levels differed significantly between the acute and chronic groups before treatment. Post-treatment, the healthy group showed no notable difference compared to either patient group. However, a significant difference was observed between the acute (0.445 μg/μL) and chronic (0.491 μg/μL) groups after treatment.

Conclusion:

Our findings suggest that MMP-9 levels in GCF increase during periapical inflammation and decrease after endodontic treatment. MMP-9 may serve as a potential diagnostic biomarker for pulp and periapical inflammation, enhancing our understanding of these clinical conditions and informing future therapeutic strategies.
Cytotoxicity of dental ceramic materials on human gingival fibroblasts
Authors: Savabi Omid , Nejatidanesh Farahnaz , Sharifi Morteza , Shirani Mohammadjavad , Valanezhad Alireza , Watanabe Ikuya , Beni Batool Hashemi , Khodaei Mohammad
Published: September 2024

Background:

This study aimed to evaluate the effect of new computer-aided design/computer-aided manufacturing all-ceramic materials on the viability and adhesion properties of human gingival fibroblasts (HGFs).

Materials and Methods:

In this experimental study, the proliferation and adhesion potential of the cells were evaluated by seeding the HGF cells on rectangular samples (n = 18 for each group). The studied groups were tetragonal zirconia (TZr), cubic zirconia (CZr), lithium disilicate (LDS), zirconia-reinforced lithium silicate (ZLS), and hybrid ceramic (HyC) (n = 6 for each studied time). The cell viability (3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay was conducted at determined times (24 h, 72 h, and 168 h) to evaluate the cell proliferation. Subsequently, the cultured cells were processed for scanning electron microscope (SEM) observation at each time interval. The surface roughness and wettability of studied ceramics were assessed using a surface profilometer and water contact angle. Differences in the cellular viability, surface roughness (Ra), and wet ability (wetting angle) of studied groups were compared by one-way analysis of variance and the Tukey multiple comparisons test (á = 0.05).

Results:

The highest percentage of cell viability after 24 h, 72 h, and 168 h cultures was related to ZLS, LDS, and CZr, respectively. The lowest proliferation of fibroblast cells was shown in ZLS compared to other groups. SEM analysis showed that the CZr and LDS groups have better adhesion patterns and morphology. The surface of HyC groups was significantly less rough than other groups. Regarding the water wetting angle (wettability), the TZr and CZr showed significantly larger angles.

Conclusion:

Within the limitation of this study, it can be concluded that CZr and LDS ceramics had better adhesion patterns and typical morphology. On the other hand, zirconia with a larger wetting angle can reduce the chance of bacteria adhesion to the surface.
An Unusual Cause of Hearing Loss in a 7-Year-Old Boy: A Case Report
Authors: Swain Santosh K.
Published: September 2024

Hearing loss is a morbid clinical entity during childhood. Idiopathic thrombocytopenic purpura (ITP) is an extremely rare cause resulting in hearing loss in pediatric age. ITP is a clinical condition commonly seen in the pediatric age group. There is autoimmune destruction of the platelets in ITP. The common clinical presentations of ITP are petechiae, ecchymoses, and epistaxis. The bleeding may occur spontaneously from the mucosal membrane of the body. However, bleeding in the middle ear leading to hemotympanum causing conductive hearing loss is an infrequent manifestation. Hemotympanum has an immediate impact on a child’s hearing and speech and needs appropriate management and follow-up. Here, a 7-year-old child with ITP presented hearing loss due to hemotympanum. In this situation, the parents of the child should be reassured that the clinical condition is self-limiting, and the hearing is affected for a short period. The child should be discharged home with a follow-up by a pediatrician and an otolaryngologist.
Anomalous Origin of Left Coronary Artery From the Right Coronary Sinus of Valsalva and Hypoplastic Left Anterior Descending Artery Presenting With Inferior Wall Myocardial Infarction: An Extremely Rare Combination of Congenital Coronary Artery Anomalies
Authors: Kumar Ritesh , Verma Mansi , Asotra Sanjeev , Kumar Ankit
Published: September 2024

Coronary artery anomalies are rare congenital disorders diagnosed incidentally during coronary artery angiograms or post-mortem examinations. The prevalence of single coronary artery (SCA) anomalies in the general population is approximately 0.024% according. Here, we report a rare case of SCA incidentally detected during management of the acute coronary syndrome.
Antidiabetic impact of novel sophorolipids produced via microbial conversion of Moringa oleifera and Lepidium sativum oil cakes utilizing locally isolated yeast strains in streptozotocin-induced diabetic wistar rats: role of glucagon-like peptide-1
Authors: Nooman Mohamed U. , Al-Kashef Amr S. , Khattab Abd El-Nasser , Ahmed Kawkab A. , Rashad Mona M. , Mahmoud Maha H.
Published: September 2024

Background

One of the top ten causes of mortality all over the world is diabetes mellitus. Egypt in particular, has one of the highest prevalence of diabetes mellitus in the world

Objective

The purpose of this work is to produce sophorolipids (SLs) economically through microbial conversion of agro-industrial wastes namely Moringa oleifera (MO) and Lepidium
sativum (LS) oil cakes using locally isolated Saccharomyces
cerevisiae and Yarrowia lipolytica, respectively. Finally, the produced SLs will be investigated for their potential use as antihyperglycemic drugs in diabetic rats.

Patients and methods

The SLs were structurally characterized by fourier transform infrared spectroscopy, hydrogen-1 proton nuclear magnetic resonance, and LC-MS/MS. Then the hypoglycemic impact of the produced SLs was evaluated through an experiment on 30 male Wistar albino rats grouped into four diabetic groups induced by a single intraperitoneal dose of streptozotocin; a control positive group, a diabetic group + reference drug (metformin), a diabetic group + MO-SLs and a diabetic group + LS-SLs and the experiment lasted for 4 weeks.

Results and conclusion

The yield of MO-SLs was 18.6 g/100 g substrate. While LS-SLs had a higher yield (43.6 g/100 g substrate). The MO-SLs declined surface tension of water to 38 mN/m at 60 mg/L critical micelle concentration however, LS-SLs levels were 46 mN/m at 50 mg/L. The chemical characterization of MO-SLs indicated the presence of lactonic and acidic forms of SLs and the LS-SLs confirmed the presence of lactonic form only. Data obtained for the hypoglycemic effect revealed that both extracts have a positive impact on the studied biochemical parameters with the best results recorded for body weight change, fasting blood glucose, alanine transaminase, insulin, and glucagon-like peptide-1 for the diabetic group receiving LS-SLs followed by the reference drug, then the MO-SLs group. The results of biochemical markers were confirmed by the histopathological examinations showing the efficiency of the produced LS-SLs in decreasing the fasting blood glucose level.
Beyond Antibiotics: Exploring Platelet-Rich Plasma Therapy in Diabetic Foot Osteomyelitis—A Case Study
Authors: Tulsian Vinay , Bansal Rifika , Kumar Sahil , Mago Vishal , Lalwani Tanya , Sanisetty Sarath , Bairwa Mukesh , Kant Ravi
Published: September 2024

Diabetic foot ulcers affect up to 15% of diabetes patients and can lead to severe complications, including osteomyelitis. Traditional treatment for diabetic foot osteomyelitis typically involves surgery and antibiotics, but outcomes can be suboptimal. This case report explores the use of Platelet-Rich Plasma (PRP) therapy as an adjunctive treatment for a 55-year-old male with Type 2 Diabetes Mellitus and diabetic foot osteomyelitis. The patient was presented with a right foot ulcer and osteomyelitis of the distal fibula, confirmed by MRI and bone scan. After initial treatment with debridement and antibiotics proved inadequate, autologous PRP therapy was introduced. Five PRP sessions were administered, scheduled every fourth day. The patient showed significant improvement with PRP therapy, highlighting its potential as a valuable non-invasive adjunct to conventional treatments for diabetic foot ulcers and osteomyelitis. This case underscores the potential of PRP therapy in managing diabetic foot complications and suggests a need for further research to establish its role in clinical practice.
Adenoviral infection in children admitted with severe acute respiratory infection at tertiary care hospital from North India: A case series
Authors: Bera Rajarshi , Pallavi Pallavi , Saxena Sonal , Chawla Shashi , Jhamb Urmila , Saxena Romit
Published: September 2024

There has been a recent surge in adenoviral infections with poor outcomes. This case series describes the clinical profile and outcome of 38 children admitted with adenovirus infection with severe acute respiratory illness (SARI). The majority (68.4%) were infants, 25 (65.7%) were immunocompetent, and 13 (34.2%) had an underlying comorbidity. Twenty-seven (71%) patients required mechanical ventilation and 5 (13.1%) were managed on a heated high-flow nasal cannula. Nine (23.6%) children developed acute respiratory distress syndrome and four (10.5%) cases developed postinfectious bronchiolitis obliterans (PIBO). The median duration of mechanical ventilation was 24 days interquartile range [11.5–34.5] days. Eleven (28.9%) children in the study population expired.
Gut microbiota modulating therapy for diabetes mellitus should be individualized
Authors: Wang Jin , Wei Hong-Juan , Mao Rui-Feng , Chang Xin
Published: September 2024

In this editorial, we commented on two articles published online in August and September 2024 in the World Journal of Diabetes , which focused on modifying the gut microbiota (GM) to prevent or delay the progression of diabetes mellitus (DM) and DM-related complications. Numerous studies, many of which are animal studies, have indicated the potential role of GM in the pathogenesis of DM. However, the detailed causality and mechanisms between GM and DM have not been fully clarified. Although there have been some reports of a potential role of modifying the GM in treating DM, most lack long-term observations and are not mechanistic. Additionally, the GM and its role in DM might vary among individuals; therefore, GM-targeted interventions should be individualized to realize their therapeutic potential.
Pojmovanje jezikovne zvrstnosti pri pouku slovenščine v gimnazijah med teorijo in prakso
Authors: Vogel Jerca
Published: September 2024

In postmodern society, the relationships between language varieties have changed. Therefore, among the most important goals of first language teaching are to enable students to achieve confident and fluent use of the standard/literary language, as well as to develop their discursive flexibility. These goals can only be achieved if we proceed from the role of the standard language in the individual’s live. In the article, we therefore first review deviations from the traditional theory of language stratification noted in Slovenian linguistics, as well as new models that have been proposed. The curriculum for teaching Slovenian as a first language in high school is then analysed in terms of its principled attitude towards linguistic diversity and the operationalisation of this relationship through precisely defined objectives and content. In conclusion, certain starting points for teaching practice and further research are suggested.
La mécanique freudienne du deuil dans À présent et Vivre Vite de Brigitte Giraud
Authors: Kotowska Katarzyna
Published: September 2024

This study explores the Freudian mechanics of mourning as depicted in Brigitte Giraud's A Present and Vivre Vite. The hypothesis posits that these two works, separated by twenty years, illustrate the evolution of mourning through a chronological examination of À présent (2001) and Vivre Vite (2022). The methodology focuses on the concepts of temporality, hallucinations, and melancholia, analyzing how these themes shift between the two narratives. The conclusion argues that Giraud's use of temporal shifts, hallucinations, and melancholic reflections in both books demonstrates the universality of Freud's mourning concept while highlighting its unique individual expressions. Notably, the shift from intense emotional expression in À présent to a more introspective approach in Vivre Vite reflects the author's own personal journey with loss and the passage of time. The study suggests that Giraud's skillful use of language serves as a vital tool for both personal healing and for capturing the collective human experience of loss and resilience.
Voix de femmes queer au coeur de la littérature haïtienne contemporaine
Authors: Vignoli Alessia
Published: September 2024

The present paper explores the representation of the romantic and/or sexual relationships maintained by some female characters and their social roles that do not conform to the heteronormative universe in a selected corpus of contemporary Haitian literary works. Our corpus consists of four works by Haitian women writers, published between 2013 and 2018: the novels Absences sans frontières (2013) by Évelyne Trouillot, Je suis vivant (2015) by Kettly Mars and Un ailleurs à soi (2018) by Emmelie Prophète, and a short story from the collection Écorchées vivantes (2017) edited by Martine Fidèle. Taking into account the current social context in Haiti, in particular social divisions and institutional homophobia, the aim of the article is to show the evolution that has taken place in the treatment of (female) homosexuality, from stigmatisation and stereotyped representations to more varied configurations that reflect contemporary realities.
Morphological fruit types of basal angiosperms in the flora of Ukraine
Authors: Odintsova Anastasiya
Published: September 2024

Basal angiosperms is a paraphyletic group of plants before branching eudicots and monocots. This group of angiosperms is of great scientific interest because it is the most ancient representative of the flowering plants retained for today. In Ukraine, both ANA-grade and magnoliids are presented. The species diversity of basal angiosperms is about half a percent of the flora of vascular plants of Ukraine, which caused a low research activity on this subject. The objectives of the present study were to elucidate the morphological diversity of fruits within basal angiosperms inhabiting Ukraine and estimate their evolutionary level and adaptations. The morphological diversity of fruit, according to our concept, comprises the structure of the gynoecium, ovary insertion, placentation, ovule number (pre-anthetic features), as well as principal fruit type and morphological adaptations for dispersal (post-anthetic features). The principal fruit types were distinguished according to the principles established previously for classifying fruits of monocots and rosids of the flora of Ukraine. Within the basal angiosperms of the flora of Ukraine, four principal fruit types were established: aggregate fruit, capsule, berry, and one-seeded fruit. Among them, the aggregate fruits are the most numerous. In Nymphaeaceae and Aristolochiaceae, which belong to the native flora of Ukraine, fruits are syncarpous, multi-seeded and inferior, while in the families cultivated in Ukraine (Annonaceae, Magnoliaceae, Calycanthaceae, Schisandraceae, and Lauraceae) fruits are apocarpous, superior and often have low seed number in a carpel. Each family has peculiar gynoecium and fruit features, which can be advanced as well as ancestral. In this article, the carpological spectrum was created to reveal the distribution of principal fruit types in families, genera, and species of the basal angiosperms of the flora of Ukraine. In these spectra, aggregate fruits are the most numerous; however, they occur in families of cultivated flora only. Most species have adaptation for dispersal by animals (birds or ants). The conclusion was made that in the native flora of Ukraine, the most derived members of basal angiosperms are retained.
Novel Approach to Autoimmune Diseases
Authors: Kuman Maria
Published: September 2024

The name autoimmune diseases means that the immune system is turned against itself. This cannot happen by itself. There should be a factor that turned the immune system against itself not to be bothered and this factor are the parasites in the body. How these small creatures can be so smart? All parasites in the body have one collective mind [1]. Proof of this is the following fact: the parasite pancreatic fluke (which lives on the pancreas) disable the pancreas. The pancreas cannot produce insulin, the blood sugar increases and this benefits the fungus (living in the intestines) that lives on sugar [1].
Scaffolding Techniques in Teaching Writing to First-Year University Students: An Empirical Study at a University in Hanoi
Authors:   Dai Nam University, Hanoi, Vietnam, Nhung Nguyen Thi
Published: September 2024

This study explores the application and effectiveness of various scaffolding techniques in improving the writing performance of first-year university students. The research focuses on three key questions: (1) how are scaffolding techniques applied in teaching writing? (2) What impact do these techniques have on students' writing performance? (3) Which scaffolding techniques are most effective in enhancing writing skills? A quantitative research design was employed, collecting data from 114 first-year students through pre-test and post-test assessments, as well as a survey among 12 teachers. The results reveal a significant improvement in post-test scores, demonstrating the overall positive impact of scaffolding techniques. Among the techniques evaluated, Utilizing Template emerged as the most effective, showing a statistically significant impact on students’ writing performance. Other techniques, such as Modelling, Guided Practice, Offering Feedback, and Peer Collaboration, did not show significant effects in this study. These findings suggest that structured guidance through templates is particularly valuable in helping students improve their writing skills, while the impact of other techniques may require a longer timeframe to fully materialize. The study highlights the importance of careful scaffolding technique selection and provides insights for improving writing instruction in academic settings.
Identification of Business Models of Cryptocurrency Companies in Indonesia (Study Case PT. Indonesia Digital Exchange and PT. Luno Indonesia)
Authors:   Postgraduate Student at School of Economic and Business, (Distance Learning) Master in Management, Faculty of Economic and Business, Telkom University, West Java, Indonesia, Kuoki Rionaldi Alamsyah , Rahadian Dadan ,   Lecturer at School of Economic and Business, (Distance Learning) Master in Management, Faculty of Economic and Business, Telkom University, West Java, Indonesia, Krisnawati Astrie ,   Lecturer at School of Economic and Business, (Distance Learning) Master in Management, Faculty of Economic and Business, Telkom University, West Java, Indonesia
Published: September 2024

Nowadays Cryptocurrency world is entering “Crypto Winter.” Crypto winter is a period of prolonged low prices pursuant to significant declines. Crypto Winter makes business development of Cryptocurrency companies enter VUCA (volatility, uncertainty, complexity, and ambiguity) where the impact is several Cryptocurrency companies in the world have gone bankrupt. Examples are FTX, Luna, Voyager Digital, Three Arrows Capital (3AC), etc. The bankruptcy of it should be prevented if it has the right strategy in making future company policies. For this reason, it is necessary to identify a business model so that it is more directed in running its business. This research seeks to identify business model of Cryptocurrency companies and identify the aspects that are the strengths of Cryptocurrency companies in Indonesia. The author uses qualitative method with case study in company PT Indonesia Digital Exchange and PT Luno Indonesia. The author will provide interview questions to company representatives to find out the business model of Cryptocurrency companies. From the research results, it is found that a cryptocurrency company business model using business model canvas consisting of nine key elements to map a business such as Key Partnership, Cost Structure, Key Resources, Key Activities, Customer Segment, Value Proposition, Customer Relationship, Revenue Streams, and Channels. The aspects of the business model that are the strength of this cryptocurrency company lie in Customer Relationship, Customer Segment, and Value Proposition. This research provides insights to map business and valuable information in the context of internal company improvement, also offering a foundation for future research.
O letramento midiático nos planos de aula da Nova Escola de Língua Portuguesa dos anos iniciais do Ensino Fundamental
Authors:   , Santos Mariana Moreira dos
Published: September 2024

Nesta pesquisa, de análise documental, investigamos como o letramento midiático vem sendo proposto nos planos de aula da plataforma Nova Escola (NE), no componente curricular Língua Portuguesa, para os anos iniciais do Ensino Fundamental. Desse modo, identificamos e selecionamos as habilidades da Base Nacional Comum Curricular (BNCC), da área de ensino analisada, que fazem referência a elementos do letramento midiático. Posteriormente, comparamos as habilidades selecionadas da BNCC com os planos de aula disponíveis na NE, para determinar as que foram utilizadas como base na construção desses planos. Especificamente, analisamos as estratégias didáticas utilizadas e como as habilidades do letramento midiático estão sendo desenvolvidas nesses planos de aula. Teoricamente, nos pautamos nas contribuições de Paulo Freire para a educação, em especial, no campo que integra a mídia e a educação e em referenciais teóricos atrelados aos multiletramentos e ao letramento midiático. Além disso, apresentamos o histórico da NE e o seu interesse pela implantação da BNCC e pela formação de professores. A partir desse histórico, refletimos sobre a motivação e o interesse de grandes empresários na educação pública do país, em especial, da Fundação Lemann, mantenedora da Associação NE, que possui grande interesse na implementação da BNCC. Nossos resultados revelaram que a maioria das propostas apresentadas nos planos de aula podem desenvolver, de maneira crítica, habilidades do letramento midiático, desde que os professores que as usam como referência no planejamento das aulas, compreendam a importância de desenvolvê-lo. De modo geral, as atividades propostas podem incentivar os estudantes a refletirem sobre os conteúdos que consomem e produzem, o que se alinha à proposta de alfabetização crítica, de Freire. Observamos também que as estratégias didáticas, descritas nos planos, podem favorecer uma participação ativa dos alunos, e promover uma abordagem dialógica e colaborativa nos processos de ensino e de aprendizagem. Entretanto, ressaltamos a importância de os professores elaborarem seus próprios planos, adaptando as sugestões de acordo com a realidade e as especificidades de suas turmas. Isso é fundamental para garantir que as práticas pedagógicas sejam eficazes e contextualizadas. Palavras-chave: Letramento Midiático; Nova Escola; BNCC; Planos de aula; Língua portuguesa.
Smart Infrastructure Management: Integrating AI with DevOps for Cloud-Native Applications
Authors:   Technology Leader in Digital Transformation for Government and Public Sector, Baltimore, Maryland, USA, Ganesan Premkumar
Published: September 2024

The integration of Artificial Intelligence (AI) with DevOps offers a transformative approach to managing cloud-native infrastructures, addressing the increasing complexity and demands of modern software environments. This paper explores the deep technical aspects of how AI can enhance DevOps practices to create intelligent infrastructure management systems that optimize resource allocation and improve performance. Key AI techniques, including machine learning (ML), deep learning (DL), reinforcement learning (RL), and AI-driven automation, are examined for their role in enhancing infrastructure scalability, reliability, and efficiency. We also provide insights into how these techniques are applied to specific components of DevOps, such as continuous integration and delivery (CI/CD), infrastructure-as-code (IaC), and cloud management. By leveraging AI-driven insights, predictive analytics, and real-time automation, this framework responds to the challenges posed by dynamic cloud-native applications, ensuring efficient, resilient, and scalable cloud environments through automated decision-making and real-time data analysis.
Assessment of Functional Outcomes and Quality of Life in Patients with Tongue Cancer after Partial Glossectomy
Authors:   Department of Oral and Maxillofacial Surgery, “Ippokrateio” General Hospital, Athens, Greece, Bourazani Malamatenia
Published: September 2024

Introduction: Tongue cancer and its therapy affect significantly patients’ quality of life (QoL) and functionality
AI, Blockchain, And Cloud Convergence: A New Paradigm For Healthcare Innovation
Authors:   Technology Leader in Digital Transformation for Government and Public Sector, Baltimore, Maryland, USA, Ganesan Premkumar
Published: September 2024

The integration of Artificial Intelligence (AI), Blockchain, and Cloud Computing is revolutionizing healthcare by enhancing data security, accessibility, and intelligence. This paper explores the synergistic benefits of combining these technologies to address key healthcare challenges such as data privacy, real-time analytics, and interoperability. We present a detailed framework and real-world applications demonstrating how AI, Blockchain, and Cloud converge to create a secure, scalable, and intelligent healthcare ecosystem. By examining current trends, potential applications, and future research directions, this paper provides insights into the transformative impact of this technological convergence on patient care and healthcare delivery.
TIC y gestión administrativa en la Escuela de Ingeniería y gestión ambiental de la Universidad Nacional Autónoma de Huanta, Ayacucho-2024
Authors: Ramos Paucar Celso
Published: September 2024

Objective: To determine the relationship between ICT and administrative management in the School of Engineering and environmental management of the National Autonomous University of Huanta, Ayacucho-2024. Method: Theoretical, descriptive and explanatory, non-experimental, correlational, sample of 80 collaborators of the entity. Results: The correlation between these variables was 0.502. Conclusions: These findings show that the effective use of IT by employees contributes to optimizing administrative management.
Ocultações estelares: os 10 anos da descoberta dos anéis de Chariklo, e os avanços no estudo do Sistema Solar
Authors: Ribas Felipe Braga
Published: September 2024

Há cerca de 10 anos anunciamos a descoberta do primeiro sistema de anéis ao redor de um pequeno corpo do Sistema Solar. A técnica de ocultações estelares, que permitiu o feito, vem sendo largamente utilizada para caracterizar objetos do Sistema Solar. Seu alto poder de resolução espacial tem permitido que dimensões e formas venham sendo obtidas, com grande precisão, para muitos objetos, desde aqueles próximos à Terra, até aqueles mais distantes do Sol. Além dos anéis de Chariklo descobertos em 2013, anéis já foram identificados ao redor do planeta-anão Haumea e do objeto transnetuniano Quaoar. Isto mostra que anéis podem ser comuns no Sistema Solar Exterior, já que limites previamente imaginados, como o Limite de Roche, não se aplicam à estes anéis. Os pesquisadores brasileiros e astrônomos cidadãos tem tido papel fundamental nesta pesquisa, a qual, graças ao LSST, deve expandir consideravelmente nos próximos anos.
Discovering Disease Biomarkers in Metabolomics via Big Data Analytics
Authors: Manik Mia Md Tofayel Gonee , Nilima Sadia Islam , Mahmud Md Abdullah Al , Sharmin Sadia , Hasan Rakibul
Published: September 2024

Purpose: This paper aims to demonstrate the utility of BDA in metabolomics and illness biomarker identification. Additionally, it will describe the metabolomics methodology and procedures, big data for metabolomics, and biomarkers utilizing these strategies. Lastly, it will highlight metabolomics possible future course and advancement as well as its incorporation into the healthcare industry.
Materials and Methods: Metabolomics data is handled via big data, which also helps find illness biomarkers. The research is conducted with simple collective analysis.
Findings: The results have found that metabolomics is a formidable tool, and its implementation has significantly improved our capacity to evaluate disease assumptions.
Implications to Theory, Practice and Policy: In the future, metabolomics and big data can be combined to help resolve challenging medical problems. By combining metabolomics with advanced blockchain, artificial intelligence, and statistical and computational analysis, metabolomics can improve the identification and finding of biomarkers. Metabolomics is a formidable tool for developing and formulating precision with large data analysis, and its integration with other "omics fields" and the addition of new technology and initiatives will bring ideas of personalized medicine to life. As metabolomics continues to evolve, further discoveries can be made in the future, benefiting the understanding of disorders and the treatment of patients.
Formulation of Business Development Strategy Through SWOT Approach and Business Model Canvas (Case Study on MSMEs in Padamulya Village)
Authors: Lestari Fitri , Muttaqin Ridlwan
Published: September 2024

This study highlights the important role of micro, small, and medium enterprises (MSMEs) in the local and national economy, especially in developing countries. It focuses on Padamulya Village in Pasirwangi District, Garut Regency. MSMEs in this village are the driving force of the regional economy through their ability to create jobs and adapt to technological changes. This study uses a qualitative approach to analyze MSME development strategies in Padamulya through SWOT analysis and Business Model Canvas (BMC). The purpose of the study is to identify the challenges faced by MSMEs, including limited capital, technology, and market access, and to formulate effective development strategies in the era of globalization. The study results indicate that MSMEs in Padamulya are in a growth phase focusing on increasing short- and medium-term profitability and product and technology innovation. Through product diversification, quality improvement, and the development of distribution channels, MSMEs in this village can strengthen their competitiveness in domestic and international markets. This study guides policymakers and MSME actors in optimizing local potential and strengthening the regional economy. It also underscores the need for further studies on implementing BMC in other MSMEs, highlighting the importance of continuous learning and improvement in the field of business development.
God Made Adam and Eve, Not Adam and Steve: Conceptualising the Legality of Sexual Minority Identity Highlighting Judicial Interpretations
Authors: Bhuiyan Evnat
Published: September 2024

This research aims to addressing the status of Sexual and Gender Minority (SGM) identity in a society. The paper pivots on three key parts- firstly, theorising minority identity and extreme social abhorrence and structural discrimination faced by SGM; secondly, assessing the legal vacuum in the existing international human rights law; thirdly, examining the judicial interpretation on right to sexual freedom as human rights and finally investigating the legality of sexual identity. For critical understanding, the study analysed how the contradictory usage of ‘public morality and decency’ creates a legal bar to avail human rights protection for SGM. For that, the paper reconnoiters ample human rights instruments and landmark US constitutional judgements to portray the nexus between sexual minority rights and human rights. The paper found SGM as a vulnerable status quo identity group who faces substantially systematic, sexuality targeted, institutional discrimination on a different scale, in extensive range and acute level which the normative binary identity minority group does not face in a heterogenous society. Court opined that sexual diversity opens newer dimension of human rights that contextualise the idea of respect to sexuality, sexual privacy, sexual freedom, sexual integrity as human rights reemphasizing SGM people’s entitlement to exercise these rights as equally as the binary people. The author primarily proposes cogent role of judicial interpretation and the establishment of an International Gender and Sexuality Protection Charter to be efficacious strategy to address sexual minority discrimination and their rights’ recognition.
Personalization Strategies and Customer Loyalty among Deposit-Taking SACCOs in Western Kenya
Authors: Akinyi Vivienne , Wanjere Dishon , Simiyu Edwin Jairus
Published: September 2024

Deposit-taking SACCOs in Western Kenya are experiencing intense competition and a declining customer base, underscoring the need for advanced personalization strategies in relationship marketing. This study aimed to evaluate the impact of personalization on customer loyalty among these SACCOs, focusing on Lifetime Value, User Satisfaction, and Conversion Rate Enhancement. Using a 5-point Likert Scale, the study assessed how SACCOs tailored services to individual needs, considering factors such as value achievement and ease of adopting new approaches. The research, grounded in Relationship Commitment, Social Exchange, and Commitment Trust theories, involved 23 SACCOs and 37,137 customers, with data collected from 396 respondents, including a pilot study. Descriptive and correlational research designs were used, and data was analyzed using SPSS with assessments of validity, reliability, and assumptions like normality and linearity. The study achieved an 87.63% response rate, revealing significant correlations (p<0.05) among variables. The findings indicated that personalization significantly influenced customer loyalty, with personalized responses and individual engagement from frontline workers enhancing loyalty, regardless of institution size. This personalized approach made customers more receptive to changes and contributed to the SACCOs’ sustainability. The study recommends that SACCOs improve customer loyalty through personalized interactions, focusing on customer lifetime value, user satisfaction, and conversion rates. It also suggests assigning frontline workers to individual members to build trust, investing in staff training for better interpersonal skills, and establishing a feedback system to continuously refine personalization strategies.
Penggunaan Kafein Sitrat pada Bayi Prematur
Authors: Marsubrin Putri Maharani Tristanita , Sugiyarto Kanya Lalitya Jayanimitta
Published: September 2024

Apnea merupakan manifestasi klinis dari pernapasan yang imatur dan sering terjadi pada bayi prematur yang dirawat di Neonatal Intensive Care Unit. Apnea of prematurity (AOP) ditandai adanya bukti apnea (henti napas) yang berlangsung 15–20 detik atau lebih, atau durasi apnea lebih singkat disertai dengan bradikardia dan/atau desaturasi. Insiden AOP berbanding terbalik dengan usia gestasi (UG) dan berat lahir. Kafein merupakan salah satu tatalaksana farmakologis untuk mengatasi AOP. Kafein termasuk golongan methylxanthine, seperti teofilin dan aminofilin. Kafein sebagai pilihan terapi AOP di negara maju sejak tahun 1970an. Sedangkan di negara berkembang, aminofilin masih menjadi obat yang paling sering digunakan untuk tatalaksana AOP. Dibandingkan dengan aminofilin dan teofilin, kafein memiliki efek terapeutik dan daya serap lebih baik, waktu paruh lebih lama, dan efek samping lebih sedikit. Oleh karena itu, kafein dijadikan terapi lini pertama untuk tatalaksana AOP.