bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge on anaphylaxis, its associated factors and self-perceived confidence on its management among medical officers attached to the Teaching Hospital Karapitiya
Authors: Dharmaratne C. J. , Dahanayaka N. J.
Published: April 2024

Introduction: Knowledge on anaphylaxis management is paramount in saving lives. The main objective of this study was to assess the knowledge on anaphylaxis, its associated factors and self-perceived confidence on its management among medical officers practising at Teaching Hospital, Karapitiya.  Methods: This cross-sectional study included all medical officers (n=531) working in Teaching Hospital Karapitiya. The data were collected within three months via a self-administered questionnaire. The questionnaire consisted of 3 main parts. Part A for demographic data, part B on knowledge on diagnosis and management of anaphylaxis generated from case scenarios and part C on self-perceived confidence on diagnosis and management of anaphylaxis.Results: The response rate was 79% (n=395). Of the respondents, only 9.36% doctors diagnosed all case scenarios correctly. Nearly a quarter (25.8%) identified all anaphylaxis triggers and 25% identified all the amplifying factors. Majority (91.9%) of doctors identified adrenaline as the first line treatment. More than 80% correctly mentioned the second line treatment with more than 90% scored for correct initial management. The score of knowledge on treatment doses of adrenaline in the paediatric age group was poor (60%). Importance of adrenaline auto-injector was identified by 69.1% but knowledge on further follow up of anaphylaxis was sub-optimal. Self-perceived confidence in diagnosis of anaphylaxis 87.6% and the self-perceived confidence in management of anaphylaxis was 83.9%.  Conclusions & recommendations: Even though the self-perceived confidence in diagnosis and management of anaphylaxis was satisfactory among the doctors, the knowledge on triggers and amplifying factors were sub-optimal. Novel educational and training strategies must be implemented to overcome the identified deficiencies.
Outcomes of anastomosis of mechanically prepared bowel vs. mechanically unprepared bowel in laparoscopic anterior resection in adult patients with rectal cancer
Authors: De Silva K. P. V. R. , Seneviratne R. W. , Kumara M. M. A. J. , Kumarasinghe J. P. M. , Abeywickrama R. P. , Gunawardena R. L. , Uluwitiya S. M. , Jayawickrama G. C. P. , Madushani W. K. T. I.
Published: April 2024

Introduction: The limited literature supporting the utilization of mechanical bowel preparation (MBP) for patients undergoing laparoscopic anterior resection of rectum (LAR) remains a notable issue. This study was conducted to examine the clinical consequences of anastomosis in rectal surgery with MBP compared to cases where MBP is not utilized (no-MBP) in the context of LAR.Methods: This is a retrospective comparative study conducted in the professorial surgical wards of Teaching Hospital Karapitiya (THK). Rectal cancer patients (n=306) participated in the study, including 151 MBP patients and 155 no-MBP patients where the postoperative complications and mortality rates were compared.Results: The anastomotic leakage rate was 2.6% (n=4) in the no-MBP group and 6.0% (n=9) in the MBP group, (p=0.143). Postoperative paralytic ileus rate was 18.5% (n=28) and 5.8% (n=9) in the MBP group and no-MBP group respectively displaying a statistically significant difference (p=0.001). Wound infection, pneumonia, urinary tract infection, and cardiac complication rates also were higher in the MBP group. Overall mortality rate was 1.3% (n=3) in no-MBP group and 2.0% (n=2) in MBP group. Conclusions: The evidence concludes that MBP increases post-operative complications. Therefore, prophylactic MBP in LAR has not been proven to benefit patients. However, further research is necessary to understand the comparative effects of MBP versus no preparation comprehensively.
Impact of the COVID-19 lockdown on antibiotic sales in suburbs of Galle
Authors: Rudrigu K. M. I. M. , Darshana I. L. A. N. , Kommalage M.
Published: April 2024

Introduction: Antibiotics are considered as one of the highest selling drug classes all over the world. This is more evident in low-income countries such as Sri Lanka. With the introduction of travel restrictions and hygiene measures due to the COVID-19 outbreak, one can expect a reduction in usage of non-COVID antibiotics among the general public. The aim of this study is to assess the impact of COVID-19 on the sales of common antibiotics in community pharmacies during the lockdown period in the suburbs of Galle district.Methods: A cross-sectional study was conducted based on reported antibiotic sales in three community pharmacies in Galle suburbs, Sri Lanka. During the two lockdown periods, information on sales of four commonly used antibiotics (Co-amoxiclav, Cefuroxime, Ciprofloxacin, and Metronidazole) were obtained from three pharmacies. For comparison, sales data for two commonly used non-antibiotic drugs (Diclofenac sodium and Losartan potassium), were obtained for the same period. Sales of these drugs were compared before and during lockdown periods using non-parametric tests at 0.05 significance level. Results: Clear reductions in sale of antibiotics and control drugs were identified during both lockdown periods. There was a significant difference between the reductions of antibiotic sale in the first and second lockdown periods (52% vs 12%, p<0.05). The reduction of sales between antibiotics and control drugs during two lockdown periods is statistically significant (p<0.001). Conclusions: There was a reduction in both antibiotic and controlled drug sales during both lockdowns. A comparatively higher antibiotic sale was identified in the second lockdown and possibly due to the relaxation of lockdown restrictions during that time.
Postural-motor development, spinal range of movement and caregiver burden in Prader-Willi syndrome-associated scoliosis: an observational study
Authors: Maccarone Maria Chiara , Avenia Mariarosa , Masiero Stefano
Published: April 2024

Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by hypothalamic dysfunction, hypotonia, cognitive deficits, and hyperphagia, primarily resulting from genetic abnormalities on chromosome 15. Among its varied manifestations, musculoskeletal issues, notably scoliosis, pose important challenges in management. This study aims to investigate differences in postural-motor development and spinal range of movement between preadolescents and adolescents with PWS, with and without scoliosis, while also exploring the potential impact of scoliosis on caregiving burden, an aspect yet to be thoroughly explored in existing literature. This observational study evaluated 13 individuals diagnosed with PWS, including 5 with scoliosis (PWS-Sc) and 7 without (PWS-NSc). Inclusion criteria comprised ages 8 to 18 years, confirmed PWS diagnosis through genetic testing, and scoliosis diagnosis. Anamnestic data, physical examinations, and surface measurements were collected, along with parental burden assessments using the Zarit Burden Interview (ZBI). Both groups displayed delays in achieving postural-motor milestones, with the PWS-Sc group exhibiting a more pronounced delay, although statistical significance was not achieved. The main curve magnitude in the PWS-Sc group averaged 31.5° Cobb, with 60% of cases presenting an S-shaped curve. Surface measurements of physiological curves did not differ significantly between groups, but the scoliosis-affected group exhibited lower lumbar extension values (p=0.04). The overall ZBI revealed higher scores in the PWS-Sc group, although statistical significance was not reached. However, significant differences were observed in single questions score evaluating aspects such as social life and caregiver uncertainty (p=0.04 and p=0.03, respectively). Despite the small sample size, delays in achieving postural-motor milestones, particularly in individuals with scoliosis, were observed. The differences recorded in lumbo-pelvic movement suggest that tailored interventions may be beneficial. The heightened caregiving burden in the scoliosis group underscores the need for targeted support. Early intervention and ongoing monitoring should be important for accurate diagnosis and appropriate care, potentially with psychological support for caregivers.
The effect of self-hypnosis on anxiety level and self-efficacy of pregnant women in dealing with childbirth during the COVID-19 pandemic
Authors: Nisa' Fauziyatun , Anggraini Fritria Dwi , Anggasari Yasi , Umamah Faridah
Published: April 2024

The COVID-19 pandemic has become a multidimensional disaster, affecting various countries, including Indonesia. Adaptation is crucial in addressing the physical and mental health challenges within communities, which includes the adaptation of pregnant women who are preparing for childbirth amidst the pandemic with the aim of reducing maternal mortality rates in Indonesia. This research aimed to assess the impact of self-hypnosis on the anxiety levels and self-efficacy of pregnant women preparing for childbirth during COVID-19. The study utilized a quasi-experimental design with pre-test and post-test measures. It involved 30 respondents in both the control and intervention groups, who were selected through consecutive sampling. Anxiety levels were measured using the Depression, Anxiety, and Stress Scale (DASS), while self-efficacy was assessed with the New General Self-Efficacy Scale. Data analysis employed paired t-tests and independent t-tests, with the significance level set at p<0.05. The results indicated a significant difference in anxiety levels and self-efficacy between the control and intervention groups, with a p-value of 0.000. Regular self-hypnosis practice positively influenced both anxiety levels and self-efficacy among pregnant women preparing for childbirth during the COVID-19 pandemic.
[Nesting of the Black Stork (Ciconia nigra) in the province of Turin]
Authors: Cattaneo Guido
Published: April 2024

[In 2023 a new nesting site of Balck Stork has been discovered for the first time in the Torino province, North-West Italy. Like most European Black Storks nesting in forest, this nest was built in a tree; in this case a Sessile Oak close to waterbodies such as rivers, streams and ponds.]
[Short Communication in Italian]
Prognostic value of a nomogram model for postoperative liver metastasis of colon cancer
Authors: Cheng De-Xin , Xu Kang-Di , Liu Han-Bo , Liu Yi
Published: April 2024

BACKGROUND

Colon cancer is one of the most common malignant tumors of the digestive system. Liver metastasis after colon cancer surgery is the primary cause of death in patients with colon cancer.

AIM

To construct a novel nomogram model including various factors to predict liver metastasis after colon cancer surgery.

METHODS

We retrospectively analyzed 242 patients with colon cancer who were admitted and underwent radical resection for colon cancer in Zhejiang Provincial People’s Hospital from December 2019 to December 2022. Patients were divided into liver metastasis and non-liver metastasis groups. Sex, age, and other general and clinicopathological data (preoperative blood routine and biochemical test indexes) were compared. The risk factors for liver metastasis were analyzed using single-factor and multifactorial logistic regression. A predictive model was then constructed and evaluated for efficacy.

RESULTS

Systemic inflammatory index (SII), C-reactive protein/albumin ratio (CAR), red blood cell distribution width (RDW), alanine aminotransferase, preoperative carcinoembryonic antigen level, and lymphatic metastasis were different between groups (P < 0.05). SII, CAR, and RDW were risk factors for liver metastasis after colon cancer surgery (P < 0.05). The area under the curve was 0.93 for the column-line diagram prediction model constructed based on these risk factors to distinguish whether liver metastasis occurred postoperatively. The actual curve of the column-line diagram predicting the risk of postoperative liver metastasis was close to the ideal curve, with good agreement. The prediction model curves in the decision curve analysis showed higher net benefits for a larger threshold range than those in extreme cases, indicating that the model is safer.

CONCLUSION

Liver metastases after colorectal cancer surgery could be well predicted by a nomogram based on the SII, CAR, and RDW.
Predicting short-term thromboembolic risk following Roux-en-Y gastric bypass using supervised machine learning
Authors: Ali Hassam , Inayat Faisal , Moond Vishali , Chaudhry Ahtshamullah , Afzal Arslan , Anjum Zauraiz , Tahir Hamza , Anwar Muhammad Sajeel , Dahiya Dushyant Singh , Afzal Muhammad Sohaib , Nawaz Gul , Sohail Amir H , Aziz Muhammad
Published: April 2024

BACKGROUND

Roux-en-Y gastric bypass (RYGB) is a widely recognized bariatric procedure that is particularly beneficial for patients with class III obesity. It aids in significant weight loss and improves obesity-related medical conditions. Despite its effectiveness, postoperative care still has challenges. Clinical evidence shows that venous thromboembolism (VTE) is a leading cause of 30-d morbidity and mortality after RYGB. Therefore, a clear unmet need exists for a tailored risk assessment tool for VTE in RYGB candidates.

AIM

To develop and internally validate a scoring system determining the individualized risk of 30-d VTE in patients undergoing RYGB.

METHODS

Using the 2016–2021 Metabolic and Bariatric Surgery Accreditation Quality Improvement Program, data from 6526 patients (body mass index ≥ 40 kg/m2) who underwent RYGB were analyzed. A backward elimination multivariate analysis identified predictors of VTE characterized by pulmonary embolism and/or deep venous thrombosis within 30 d of RYGB. The resultant risk scores were derived from the coefficients of statistically significant variables. The performance of the model was evaluated using receiver operating curves through 5-fold cross-validation.

RESULTS

Of the 26 initial variables, six predictors were identified. These included a history of chronic obstructive pulmonary disease with a regression coefficient (Coef) of 2.54 (P < 0.001), length of stay (Coef 0.08, P < 0.001), prior deep venous thrombosis (Coef 1.61, P < 0.001), hemoglobin A1c > 7% (Coef 1.19, P < 0.001), venous stasis history (Coef 1.43, P < 0.001), and preoperative anticoagulation use (Coef 1.24, P < 0.001). These variables were weighted according to their regression coefficients in an algorithm that was generated for the model predicting 30-d VTE risk post-RYGB. The risk model's area under the curve (AUC) was 0.79 [95% confidence interval (CI): 0.63-0.81], showing good discriminatory power, achieving a sensitivity of 0.60 and a specificity of 0.91. Without training, the same model performed satisfactorily in patients with laparoscopic sleeve gastrectomy with an AUC of 0.63 (95%CI: 0.62-0.64) and endoscopic sleeve gastroplasty with an AUC of 0.76 (95%CI: 0.75-0.78).

CONCLUSION

This simple risk model uses only six variables to assist clinicians in the preoperative risk stratification of RYGB patients, offering insights into factors that heighten the risk of VTE events.
Impact of different anastomosis methods on post-recurrence after intestinal resection for Crohn's disease: A meta-analysis
Authors: Wang Zheng-Zuo , Zhao Chun-Hua , Shen Hui , Dai Gui-Ping
Published: April 2024

BACKGROUND

Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, often requiring intestinal resection as a common treatment. However, recurrence after surgery is common. The anastomotic configuration after bowel resection appears to be associated with the recurrence of CD. Previous studies have suggested that the Kono-S anastomosis may help to reduce the recurrence rate. However, the results remain controversial. Therefore, evidence-based evidence is needed to prove the advantages of Kono-S anastomosis.

AIM

To measure the influence of anastomosis techniques on the long-term relapse rate of CD by conducting a meta-analysis.

METHODS

PubMed, Scopus, and Cochrane Library were searched until October 8, 2023. Patients who underwent intestinal resection due to CD were included. The intervention measures included Kono-S anastomosis, whereas the control group received traditional anastomosis such as end-to-end, end-to-side, and side-to-side anastomosis. Only randomized clinical trials and observational studies were included. The primary outcome measures were hospital stay post-surgery, overall postoperative complication incidence, the proportion of Clavien-Dindo grade IIIa or higher, overall postoperative recurrence rate, and Rutgeerts score.

RESULTS

From 2011 to 2023, six articles met the inclusion and exclusion criteria. The results indicated that Kono-S anastomosis can reduce the hospital stay post-surgery of patients with CD [MD = -0.26, 95%CI: -0.42 to -0.10, P = 0.002] than other traditional anastomosis methods. Compared to other traditional anastomosis methods, Kono-S anastomosis can significantly reduce the total recurrence rate [MD = 0.40, 95%CI: 0.17 to 0.98, P = 0.05] and postoperative Rutgeerts score [MD = -0.81, 95%CI: -0.96 to -0.66, P < 0.001] in patients with CD. However, there is no significant disparity in the overall occurrence of postoperative complications and the proportion of Clavien-Dindo ≥ IIIa.

CONCLUSION

Kono-S anastomosis has the potential to expedite the recuperation of CD and diminish relapse hazards; however, additional larger trials are necessary to authenticate its effectiveness.
Catalytic Converter—An Integrated Approach to Reduce Carbon Dioxide
Emission
Authors: Saravanakumar L. , Arunprasad S.
Published: April 2024

Vehicle emissions, which are rising alarmingly quickly, are a significant
contributor to the air pollution that results. Incomplete combustion, which
results in the release of chemicals including carbon monoxide, hydrocarbons, and
particulate matter, is the main cause of pollutants from vehicle emissions.
However, CO2 contributes more than the aforementioned pollutants
combined. Carbon dioxide is the main greenhouse gas that vehicles emit. For
every liter of gasoline burned by vehicles, around 2,347 grams of carbon dioxide
are released. Therefore, it’s important to reduce vehicle emissions of carbon
dioxide. The ability of materials like zeolite and silicon dioxide to absorb
CO2 is outstanding. These substances transform CO2
into their own non-polluting carbonate molecules. Zeolite, silicon dioxide, and
calcium oxide are combined to form the scrubbing material in a ratio based on
their increasing adsorption propensities, along with enough bentonite sand to
bind the mixture.
Hypoxia-inducible factor-1α in myocardial infarction
Authors: Škrlec Ivana , Kolomeichuk Sergey N
Published: April 2024

Hypoxia-inducible factor 1 (HIF1) has a crucial function in the regulation of oxygen levels in mammalian cells, especially under hypoxic conditions. Its importance in cardiovascular diseases, particularly in cardiac ischemia, is because of its ability to alleviate cardiac dysfunction. The oxygen-responsive subunit, HIF1α, plays a crucial role in this process, as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival, angiogenesis, and metabolism. Furthermore, HIF1α expression induced reperfusion in the ischemic skeletal muscle, and hypoxic skin wounds in diabetic animal models showed reduced HIF1α expression. Increased expression of HIF1α has been shown to reduce apoptosis and oxidative stress in cardiomyocytes during acute myocardial infarction. Genetic variations in HIF1α have also been found to correlate with altered responses to ischemic cardiovascular disease. In addition, a link has been established between the circadian rhythm and hypoxic molecular signaling pathways, with HIF1α functioning as an oxygen sensor and circadian genes such as period circadian regulator 2 responding to changes in light. This editorial analyzes the relationship between HIF1α and the circadian rhythm and highlights its significance in myocardial adaptation to hypoxia. Understanding the changes in molecular signaling pathways associated with diseases, specifically cardiovascular diseases, provides the opportunity for innovative therapeutic interventions, especially in low-oxygen environments such as myocardial infarction.
Partial-dual polynomial as a framed weight system
Authors: Deng Qingying , Dong Fengming , Jin Xian'an , Yan Qi
Published: April 2024

Recently, Chmutov proved that the partial-dual polynomial considered as a
function on chord diagrams satisfies the four-term relations. In this paper, we
show that this function on framed chord diagrams also satisfies the four-term
relations, i.e., is a framed weight system.
SHAPE'S IMPACT ON DIMENSIONAL PRECISION IN 3D PRINTED COMPONENTS
Authors: Sucuoğlu Hilmi Saygın , Böğrekci İsmail , Demircioğlu Pınar
Published: April 2024

In this comprehensive exploration, the study explores the relationship between shape and the dimensional accuracy of components manufactured through additive manufacturing processes. The methodology involves the adept utilization of Autodesk Inventor Software, strategically embossing capital letters from A to O onto a rectangular plate. The resulting models are exported in STL format, laying the foundation for rapid prototyping. The investigation unfolds with the application of a Prusa İ3 desktop 3D printer, where specific settings, including layer height (ranging from 90 to 300 microns), 20% infill density, and a heated bed temperature of 60 ºC, are scrupulously chosen. Three different embossing methods are examined in this study in order to see how each affects dimensional correctness. These methods are join, cut half, and cut through. Through a meticulous comparative analysis, facilitated by high-resolution image acquisition and advanced processing techniques like binarizing and edge detection, the study discerns that embossing with join yields shapes characterized by higher dimensional accuracy, a conclusion substantiated by correlation coefficient analysis. This research stands as a significant contribution, offering valuable insights into optimizing additive manufacturing processes and elevating dimensional precision in 3D printed components.
ANALISIS DAMPAK POLIGAMI DALAM KEHARMONISAN RUMAH TANGGA: STUDI KASUS DI KECATAMAN KANIGARAN KOTA PROBOLINGGO
Authors: Hoiriyah Rosidatul , Fida Imanuddin Abil
Published: April 2024

This article aims to examine the concept of the impact of polygamy on household harmony which is currently, widespread in people’s lives today. The family, as a unit formed from marriage, creates a relationship that is Sakinah, Mawadah, Warahmah. Polygamy, is a process in which a man has more than one wife at the same time, Islam allows it with certain conditions.       However, the psychological impact on wives and children includes family conflict, competition between wives, as well as negative impacts on children’s development, including lack of love and trauma. Justice in polygamy is the key to preventing these negative impacts.
Keywords:  Polygamy; Impact of Polygamy; Family.
DETERMINATION OF HEAVY METALS IN FRESH FISH
Authors:   University of Sarajevo, Faculty of Agriculture and Food Science, Bosnia and Herzegovina, Karahmet Enver , Isaković Senita , Toroman Almir ,   University of Sarajevo, Faculty of Agriculture and Food Science, Bosnia and Herzegovina, Bečić Ervina ,   University of Sarajevo, Faculty of Farmacy, Bosnia and Herzegovina, Marković Zoran ,   University of Kragujevac, Institute for Information Technologies, Serbia
Published: April 2024

Consumption of fish has increased in last 50 years. Fish as a food is changing red meat because it has unsaturated fat and it is the best source of omega 3 fatty acids. Beside it is full of minerals, vitamins and it has high biological value of proteins.The content of heavy metals in the muscle tissue of fish is directly related to the pollution of the water they come from The analysis of the content of heavy metals was done by the Institute of Public Health of the Federation of Bosnia and Herzegovina.The content of lead (Pb) in the tested samples of fresh fish ranged from 0.0015 to 0.0381 mg/kg. The measured content of cadmium (Cd) in the examined samples was in the range of 3.3*10-5 to 0.0053 mg/kg. The content of arsenic (As) in the tested samples ranged from 0.0085 to 1.1668 mg/kg. The mercury (Hg) content in the tested samples of fresh fish ranged from 0.0033 to 0.0991 mg/kg, which is within the allowed values prescribed by the Rulebook. It has been statistically proven that there is a significant difference in the measured values of lead, arsenic and cadmium in the samples of sea and freshwater fish. Aim of this work was to establish do the samples of fresh fish contain concentration of heavy metals more than concentrations prescribed in Rule book about allowed amounts of certain contaminants in food. Thereby ten samples of fresh fish were tested, five samples of marine fish and five samples of freshwater fish. Results showed that all samples of fish satisfy allowed concentration of heavy metals according to the Rule book.
ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF ZIZYPHUS JUJUBA L. LEAF EXTRACTS
Authors:   University of Kragujevac, Faculty of Agronomy, Serbia, Đurović Vesna , Radenković Sofija ,   University of Kragujevac, Faculty of Agronomy, Serbia, Mandić Leka ,   University of Kragujevac, Faculty of Agronomy, Serbia, Radovanović Mirjana ,   University of Kragujevac, Faculty of Agronomy, Serbia, Pešaković Marijana ,   Fruit Research Institute, Čačak, Serbia, Bošković Ivana ,   University of East Sarajevo, Faculty of Agriculture, East Sarajevo, Bosnia and Herzegovina, Đukić Dragutin ,   University of Kragujevac, Faculty of Agronomy, Serbia
Published: April 2024

The aim of the present study was to investigate the biological activities of the extracts obtained from leaf of Ziziphus jujuba. To reach this purpose, total phenolic content (TPC), total flavonoid content (TFC), DPPH and ABTS radical scavenging activity, as well as antibacterial activity extracts were evaluated. The content of total phenols in leaf ranged from 22.71 to 28.69 mg GAE/g, the total content of flavonoids ranged from 5.15 mg RE/g to 8.25 mg RE/g depending on the applied extraction method. All extracts showed very high antioxidant activity. The ethanol extracts of Ziziphus jujuba leaf were screened for antibacterial activities against Salmonella typhimurium, Salmonella enteritidis, Listeria ivanovii, Listeria monocytogenes, Staphylococcus aureus and Pseudomonas aerogenes using microdilution method. Furthermore, the highest antibacterial activity was observed against Salmonella typhimurium and Salmonella enteritidis. The present results suggested the promising antioxidant and antibacterial properties of Ziziphus jujuba leaf extracts, which can be used in the fabrication of functional bioactive ingredients for different purposes.
AUTOMATIC CONTROL AND ARTIFICIAL INTELLIGENCE: DEVICE FOR CONTINUOUS CHLORINE RESIDUAL MEASUREMENT
Authors:   University of Kragujevac, Faculty of  Agronomy, Čačak, Serbia, Trišović Tomislav , Trišović Ana ,   Massachusetts Institute of Technology, USA, Rafailović Lidija , Grgur Branimir ,   University of Belgrade, Faculty of Technology and Metallurgy, Serbia, Trišović Zaga ,   The Academy of Applied Technical Studies Belgrade, Belgrade, Serbia
Published: April 2024

Bacteriologically safe water is crucial for potable and food production, which is obtained using disinfection. Disinfectants must be broad-spectrum, act swiftly, withstand organic matter, maintain stability across pH levels, be non-toxic, minimally corrosive, and pleasant-smelling. Precise dosing is vital, typically achieved via automated membrane dosing pumps, and is ensured by measuring residual chlorine post-disinfection. This paper introduces devices utilising amperometric electrodes to maintain active chlorine levels of 0.2 to 0.5 mg/l. Industrial computer and touch panel aid data storage and visualisation, enabling performance prediction via machine learning. Deployed at the dairy company Kozanostra in Osečina, it’s a major water safety advancement.
INFLUENCE OF CONTROLLED RADIATION ON THE PROPERTIES OF BIOCOMPATIBLE SILICONE ELASTOMERS
Authors:   College of Vocational Studies for Management and Business Communications, Belgrade, Serbia, Cvjetković Jovana , Manjenčić Darko ,   College of Vocational Studies for Management and Business Communications, Belgrade, Serbia, Mićić Vladan ,   University of East Sarajevo, Faculty of Technology, Republic of Srpska, Manjenčić Anja ,   University of Belgrade, Faculty of Medicine, Serbia
Published: April 2024

For everyone involved in the synthesis, processing and application of elastomers, it is necessary to know how an elastomeric material will behave under the influence of different types of energy. The aim of this work is to establish the resistance of biocompatible silicone elastomers to the permitted doses of radiation. Elastomeric materials were irradiated with gamma rays in a Co-60 radiation chamber with a dose of 25 kGy/h. By determining the various properties before and after irradiation of the silicone material, it was found that the resistance to radiation is significantly improved in samples reinforced with silicon (IV) oxide nanoparticles. FTIR spectroscopy was used to confirm the assumed mechanism of the crosslinking reaction of siloxane. The analysis of the thermal properties of the synthesized siloxane materials was performed using a DSC device, which showed that the proportion of nanofillers and vinyl functional groups significantly affects the values of the melting temperatures before and after irradiation.
GERANIUM MACRORRHIZUM, THE CURE IN YOUR GARDEN. NEW METHOD OF GERMACRONE ISOLATION
Authors:   University of Niš, Faculty of Sciences and Mathematics, Serbia, Petrović Goran , Đorđević Aleksandra ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Stamenković Jelena ,   University of Niš, Faculty of Medicine, Serbia, Dimitrijević Marija ,   University of Niš, Faculty of Medicine, Serbia, Nikolić Jelena ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Stankov Jovanović Vesna ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Mitić Violeta ,   University of Niš, Faculty of Sciences and Mathematics, Serbia
Published: April 2024

Geranium macrorrhizum L., commonly known as “Zdravac” is an herbaceous medicinal plant that is traditionally used to treat skin diseases such as cuts, burns, and eczema. The essential oil obtained from the aerial parts of the plant is widely used in ethnopharmacology, perfumery and cosmetics. Germacrone is a bioactive natural compound found as part of the essential oils of different plants that are widely distributed throughout the world. This multifaceted chemical entity has become a point of focus during recent years due to its numerous pharmacological applications. The aim of the present study was to determine the chemical composition of the essential oil obtained from aerial parts of Geranium macrorrhizum and to develop the new method of pure germacrone isolation as its main component.
ANTITUMOR EFFECTS OF TANACETUM BALSAMITA ESSENTIAL OILS BY DOWNREGULATION NRF-2 AND MMP-9 IN BREAST CANCER
Authors:   University of Kragujevac, Faculty of Science, Serbia, Obradović Ana , Vukić Milena ,   University of Kragujevac, Faculty of Science, Serbia, Paunović Milica ,   University of Kragujevac, Faculty of Science, Serbia, Ognjanović Branka ,   University of Kragujevac, Faculty of Science, Serbia, Vuković Nenad ,   University of Kragujevac, Faculty of Science, Serbia, Kačániová Miroslava ,   Slovak University of Agriculture, Institute of Horticulture, Faculty of Horticulture and Landscape Engineering,  Nitra, Slovakia, Matić Miloš ,   University of Kragujevac, Faculty of Science, Serbia
Published: April 2024

The aim of this study was to investigate antitumor capacity of different Tanacetum balsamita essential oils by measuring apoptosis rate, MMP-9 concetration and Nrf-2 expression level in human MBA-MB-468 and MDA-MB-231 cells. The tested EOs expressed proapoptotic effects, significantly inhibited the MMP-9 concentration and down-regulated the expression level of Nrf-2. The obtained data suggest that the tested EOs exert considerable antitumor activity elevating apoptosis level and inhibiting the motility of tested cancer cells. The reduced levels of Nrf-2 expression suggest decreased defense potential for oxidative disturbances, which could be the major antitumor mechanism detected in the study.
INFLUENCE OF EXTRACTION SOLVENTS ON THE PHENOLIC PROFILE OF ROSA DUMALIS BECHST. FRUIT SAMPLES
Authors:   University of Niš, Faculty of Sciences and Mathematics, Serbia, Milenković Katarina , Mrmošanin Jelena ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Petrović Stefan ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Zlatković Bojan ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Tošić Snežana ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Mitić Milan ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Pavlović Aleksandra ,   University of Niš, Faculty of Sciences and Mathematics, Serbia
Published: April 2024

The phenolic content of investigated Rosa dumalis fruit samples were studied. To obtain a more detailed phenolic profile, five solvents with different polarities (water, ethanol, 60% ethanol, methanol and acidified 80% methanol) were used for the preparation of the plant extracts. Individual phenolics were analyzed using high performance liquid chromatography (HPLC). The obtained results indicate that the investigated R. dumalis samples are rich in both phenolic acids and flavonoids. Acidified 80% methanol extracts had the highest yields followed by the 60% ethanol, water, methanol, and ethanol.
EFFECTS OF STANDARDIZED ARONIA MELANOCARPA EXTRACT ON CARDIOVASCULAR SYSTEM: FROM BASIC TO APPLIED INVESTIGATION
Authors:   University of Kragujevac, Faculty of Medical Sciences, Serbia, Jakovljević Vladimir ,   Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders
Published: April 2024

This study summarizes the effects standardized Aronia melanocarpa extract (SAE) on different pathophysiological processes linked with cardiovascular system from both animal and human investigations. In basic researches we estimated the influence of SAE on rats with metabolic syndrome (MetS) and polycystic ovary syndrome (PCOS). Human studies aimed to assess the impact of SAE in patients with MetS and in professional handball players. SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Furthermore, SAE induced a wide range of beneficial effects in human researches. Overall, SAE could be a promising strategy to reduce cardiovascular risk.
INSIGHT INTO SELECTED QUALITY PARAMETERS OF MEDLAR (MESPILUS GERMANICA L.) FRUIT GROWN IN SERBIA
Authors:   University of Belgrade, Faculty of Agriculture, Serbia, Mićanović Nenad , Đurović Sanja ,   Institute for Plant Protection and Environment, Belgrade, Serbia, Naumovski Nenad ,   University of Canberra, Faculty of Health, School of Rehabilitation and Exercise Sciences, Australia, Mickovski Stefanović Violeta ,   Tamiš Research and Development Institute, Pančevo, Serbia, Li Hanbing ,   Zhejiang University of Technology, Hangzhou, PR Chi, Popović-Đorđević Jelena ,   University of Belgrade, Faculty of Agriculture, Serbia
Published: April 2024

Medlar (Mespilus germanica L.) is considered as underutilized fruit, it is nutritionally valuable rich in both primary and secondary metabolites. In this work the physicochemical composition and antioxidant properties of medlar fruits originated from different locations in Serbia were examined. The moisture and protein contents of the fruits were in the ranges 73-79% and 0.43-0.47% w/w, respectively. The aveage total phenolic content and antioxidant activity measured by DDPH and FRAP assays, were 2131.62 μg/GAE/g, 1306.6 μmol TE/g and 916.46 μmol Fe2+ eq, respectively. Chlorogenic acid (9.61-11.62 μg/g) was the most abundant phenolic acid, whereas contents of catechin (9.69-11.51 μg/g) and epicathenine (7.29-25.31 μg/g) were the highest in most of samples.
PRÁTICA DE ENSINO COMO COMPONENTE CURRICULAR NO CURSO DE LICENCIATURA EM MATEMÁTICA DO PROGRAMA UNIVERSIDADE ABERTA DO BRASIL DA UNIVERSIDADE FEDERAL DO CEARÁ
Authors: ANDRADE PEREIRA GABRIELLE , MARTINS TORRES ANTONIA LIS DE MARIA , BORGES NETO HERMÍNIO
Published: April 2024

Este artigo objetiva compreender como são realizadas as práticas de ensino, enquanto componente curricular do curso de Licenciatura em Matemática do Programa Universidade Aberta do Brasil da Universidade Federal do Ceará. Este é um estudo de caso, desenvolvido através de pesquisa documental e entrevista. Assim, utilizamos o Projeto Pedagógico do Curso (PPC), o programa de disciplinas e os dados coletados na entrevista com um professor do curso. O Conselho Nacional de Educação exige que sejam vivenciadas quatrocentas horas de práticas de ensino durante o curso. No PPC, observamos que as práticas estão distribuídas nas disciplinas em forma de atividades, no qual cita-se exemplos. No programa de disciplinas determina-se apenas os conteúdos dos encontros presenciais. Na entrevista, o professor afirma que realizam debates, nos fóruns de discussão, sobre como abordar determinados conteúdos na Educação Básica e busca-se relacionar com o uso de softwares educativos. Não há mais encontros presenciais. O fórum possui grande potencial didático, porém, o docente comenta que, às vezes, a ferramenta não é explorada como deveria. Diante do exposto, sugerimos estratégias para o uso dessa ferramenta nas práticas de ensino, tais como: solicitar que os discentes elaborem e compartilhem planejamentos e aplicações de sessões didáticas; orientar que eles façam questionamentos e debatam sobre as aulas construídas pelos colegas; conteúdo, metodologia e recursos didáticos devem visar o ensino da matemática escolar. Assim, estimula-se o protagonismo e a prática de ensino dos discentes, fazendo com que eles vivenciem as ações docentes e tenham a oportunidade de refletir, com base nas discussões realizadas.
Estratégias de educação em saúde para promoção do autocuidado com um grupo de usuários hipertensos
Authors: Santos Wagner Pereira dos , Medeiros Neta Olivia Morais de , Amorim Erico Gurgel
Published: April 2024

A hipertensão arterial sistêmica (HAS) é um importante problema de saúde pública, reconhecida como fator de risco para complicações cardíacas e cerebrovasculares. Este relato descreve as ações decorrentes da participação de um Residente da Residência Multiprofissional em Atenção Básica na condução de um grupo de usuários hipertensos em uma unidade de saúde da família. A metodologia foi baseada na realização de intervenções educativas com estratégias de saúde no município de Caicó, no estado do Rio Grande do Norte. Os participantes demonstraram participação ativa, favorecendo a construção coletiva de conhecimento. Os resultados indicaram que as atividades foram benéficas para a conscientização dos usuários sobre o autocuidado, a promoção de hábitos saudáveis e a importância do acompanhamento adequado. Nesse sentido, a presente experiência mostra-se relevante para promover a conscientização dos hipertensos quanto à adoção de hábitos saudáveis e à necessidade de monitoramento adequado.
Customer Satisfaction in the South Denpasar Region as a Measure of Brand Loyalty and the Impact of Product Quality and Image
Authors:   Student of Postgraduate Magister Management, University of Merdeka Malang, Indonesia, Susilawati Ni Made Budi
Published: April 2024

Companies need to pay attention to the high consumption of consumers or customers to be more innovative to meet customer needs and desires with quality products or services created for the long term so that customers will retain and feel satisfied in meeting their needs, which can generate customer loyalty. Factors such as product quality, brand image, and customer satisfaction influence customer loyalty. This study aims to analyse the effect of product quality and brand image on customer loyalty through customer satisfaction in South Denpasar. This quantitative research obtained a sample of 100 respondents with a purposive sampling method. The data analysis techniques used are descriptive analysis, classic assumption test, t-test, and path analysis. The research results show that product quality and brand image can influence customer loyalty for Bebelac products in the South Denpasar District. Product quality and brand image can influence customer satisfaction with Bebelac products in South Denpasar District. The research results show the influence of product loyalty on Bebelac customer satisfaction in the South Denpasar District. Research results show product quality brand image can influence customer loyalty through customer satisfaction with Bebelac products in the District of South Denpasar.
A Systematic Review of Microvascular Reconstruction Techniques in Head and Neck Surgery: Accessing Advancements in Surgical Methods and Functional Outcomes
Authors:   Medicine, Pontificia Universidad Católica del Ecuador, Pungacho Espin Nathalie Estephania , Muñoz Cedeño Yuletzi Dayanna ,   Medicine, Universidad Laica Eloy Alfaro de Manabí ULEAM, Vera Cruzatty José Manuel ,   Medicine, Universidad Laica Eloy Alfaro de Manabí ULEAM, Narváez Jordan Diego Jacob ,   Medicine, Ministerio de Salud Pública Ecuador, Herrera Santiago Israel Cárdenas Herrera ,   Medicine, Revit Medical, Usiña Magaly Morelia Sacancela ,   Medicine, Universidad de las Amércias, Pesántez Germán Agustín Veléz ,   Medicine, Universidad Católica de Cuenca, Alonso Madero Jorge Luis ,   Master’s Degree in Health Promotion and Community Health, Universidad Internacional Iberoamericana de México
Published: April 2024

In recent years, microvascular reconstruction in head and neck surgery has gained significant advancements. With advent of latest technological innovations in microvascular reconstruction techniques, now surgeons have better and more safe option of critical surgeries such as neck and head. Scientists now have a deeper understanding of anatomical complexities because of the latest knowledge and tools. In this systematic review, we aim to discuss the latest technological advancements in head and neck surgery and what kind of microvascular reconstruction techniques are performed with novel surgical methods. Innovations like Augmented Reality (AR) integration, patient-specific implants, and 3D-printed surgical guides have improved surgical outcomes. This review discusses dynamic microvascular reconstruction techniques for facial paralysis. We have emphasised the success of immediate functional gracilis transfer and chimeric flaps. We will discuss novel strategies such as microvascular alternative donor site technology and the adoption of immediate dental implants, which have also contributed to improved aesthetic and functional outcomes.
Managing Acne in Individuals with Polycystic Ovarian Syndrome
Authors:   ISSSTE Dr Santiago Ramón y Cajal, Guerrero Carrillo Daniela , Barajas Jorge Eduardo González ,   UMAE Hospital Ginecología y Obstetricia 23
Published: April 2024

Acne vulgaris is a prevalent, long-lasting skin condition that affects individuals aged 15 to 40. It appears to be a common ailment that occurs during adolescence. Nevertheless, it frequently impacts adults as well. Polycystic ovarian syndrome (PCOS) is a prevalent cause of acne vulgaris in adult women. The presence of hyperandrogenism and metabolic problems in this condition may lead to the development of comedones, papules, and nodules on the face, chest, and back. This article specifically examines the current therapies for acne that are linked to polycystic ovarian syndrome.
Cointegration Modeling for COVID-19 Infected Cases and Deaths in the US
Authors: Rajarathinam Arunachalam
Published: April 2024

Abstract

This paper aims to study the short-run and long-run cointegration relationships between the total population, the cumulative number of new COVID-19-infected cases, and the cumulative number of deaths due to COVID-19 in different states in the US. The short-run relationship is assessed using the ARDL model, and the long-run relationship is assessed using the ARDL bounds test. To assess the consistency of the model parameters, the cumulative sum of recursive residuals test and the cumulative sum of recursive residuals squares tests are used.

JEL classification numbers: E18, HO, I1, J64, J88.
Keywords: Autoregressive distributed lag model, Error correction model, Unit root tests, Residual diagnostics, Bounds cointegration test, Stability tests.
OBSTETRIC FISTULA: RISK FACTORS AND SOCIO-DEMOGRAPHIC CHARACTERISTICS AMONG PATIENT ADMITTED IN AL-SADAQA TEACHING HOSPITAL, ADEN, REPUBLIC OF YEMEN (1\(^{st}\) JAN 2014 - 31\(^{st}\) DEC 2019)
Authors: Al-Maisary Mariam M. , Al-Kaaky Nahla S.
Published: April 2024

Obstetric fistula is one of the major obstetric problem that results from prolonged obstructed labor. This condition mainly effect on women in the underdeveloped and developing nations of the world specially in Africa and Asia and Yemen one of them. Each year, an estimate of 50, 000-100, 000 women develop obstetric fistula worldwide. It occurs in areas where access to care at childbirth is limited or poor quality care during intrapartum period. to study the risk factors (social, demographic and obstetric) of Obstetric Fistula among Al-Sadaqa Teaching Hospital patients, Aden- Yemen. A hospital based cross-sectional descriptive study was carried out for 51 medical files of obstetric fistula patients admitted to fistula unit in Al-Sadaqa Teaching hospital in Aden city during the study period from 1st Jan 2014 to 31st Dec 2019.Using available data technique and questionnaire were used to collect the study data from medical files available in the hospital . This data were analyzed by SPSS software (version22). Most of obstetric fistula patients were from rural areas (60.8%), in the age group 20-34years (56.9%). Early age of marriage of age group 15-20 years (80.4%), illiterate (47.1%) and still married despite having obstetric fistula (92.2%)with non-used ANC in the causative pregnancy (41.2%) and have history of previous one and more caesarian section (19.6%, 11.8% respectively) .Most of participants delivered vaginally (54.9%) by midwives (72.5%) where prolonged obstructed labor was the most cause (49%) and most common type is rectovaginal fistula (41.2%) and the majority of fistula repair was through transvaginal (68.6%). The risk factors of obstetric fistula are early age of marriage, illiteracy, and lack of antenatal care, while obstructed prolonged labor was most common cause. Rectovaginal fistula is the commonest type. The study findings clear that obstetric fistula is important obstetric problem faced community and increasing maternal morbidity, significance of both treatment and prevention activities needed, also interventions that focus on improving access to maternal health care, emergency obstetric care, and increase rate of caesarean section when indicated.
مدى مشروعية التدخل العسكري الإنساني "دراسة تحليلية"
Authors: الوهيبي إعتصام العبد صالح
Published: April 2024

تناولت الدراسة مدى مشروعية التدخل العسكري الإنساني، والذي يعد من المفاهيم التي باتت تشغل بال المهتمين بالقانون الدولي وغيرهم، لما له من أثر كبير على مستقبل مفهوم السيادة الوطنية، حيث أصبح جلياً أن بعض الدول الكبرى تستخدم هذا المفهوم أحيانا لتحقيق أهداف خاصة قد لا تتعلق بالضرورة بحماية ضحايا العنف الذي تمارسه الدول، مما يوضح ضرورة السعي إلى تقنين مفهوم التدخل العسكري الإنساني وتقييد استخدامه حتى لا يكون سبباً لانتهاك سيادة الدول، وأصبح لزاماً على الدول الالتزام بالمعاهدات والاتفاقيات الدولية المتعددة، خاصة تلك التي تتعلق بالقانون الدولي الإنساني، وحقوق الإنسان، وجعلت من التدخل مسألة مشروعة، وفقا لميثاق الأمم المتحدة في رأي الكثير من الفقهاء، وذلك في حالة انتهاك الدولة المعنية لالتزاماتها الدولية التي تفرضها عليها المعاهدات الدولية، من خلال ارتكاب الجرائم التي تصنف ضمن الجرائم الأشد خطورة على الإنسانية، كما أن بعض الدول الكبرى تسعى إلى  استغلال مفهوم التدخل العسكري الإنساني من أجل تحقيق أهداف خاصة لا علاقة لها بحماية السلم والأمن الدوليين.