bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating repellent and attractant semiochemicals into a push–pull strategy for ambrosia beetles (Coleoptera: Curculionidae)
Authors: Werle Christopher T. , Ranger Christopher M. , Schultz Peter B. , Reding Michael E. , Addesso Karla M. , Oliver Jason B. , Sampson Blair J.
Published: November 2018

Non‐native ambrosia beetles (Coleoptera: Curculionidae), especially Xylosandrus compactus (Eichhoff), Xylosandrus crassiusculus (Motschulsky) and Xylosandrus germanus (Blandford), are destructive wood‐boring pests of trees in ornamental nurseries and tree fruit orchards. Previous studies have demonstrated the adults are repelled by verbenone and strongly attracted to ethanol. We tested a “push–pull” semiochemical strategy in Ohio, Virginia and Mississippi using verbenone emitters to “push” beetles away from vulnerable trees and ethanol lures to “pull” them into annihilative traps. Container‐grown trees were flood‐stressed to induce ambrosia beetle attacks and then deployed in the presence or absence of verbenone emitters and a perimeter of ethanol‐baited interception traps to achieve the following treatment combinations: (a) untreated control, (b) verbenone only, (c) ethanol only, and (d) verbenone plus ethanol. Verbenone and ethanol did not interact to reduce attacks on the flooded trees, nor did verbenone alone reduce attacks. The ethanol‐baited traps intercepted enough beetles to reduce attacks on trees deployed in Virginia and Mississippi in 2016, but not in 2017, or in Ohio in 2016. Xylosandrus germanus, X. crassiusculus and both Hypothenemus dissimilis Zimmermann and X. crassiusculus were among the predominant species collected in ethanol‐baited traps deployed in Ohio, Virginia and Mississippi, respectively. Xylosandrus germanus and X. crassiusculus were also the predominant species dissected from trees deployed in Ohio and Virginia, respectively. While the ethanol‐baited traps showed promise for helping to protect trees by intercepting ambrosia beetles, the repellent “push” component (i.e., verbenone) and attractant “pull” component (i.e., ethanol) will need to be further optimized in order to implement a “push–pull” semiochemical strategy.
Esthetic and functional rehabilitation of bilateral congenital absence of maxillary lateral incisors: Minimally invasive surgical and prosthetic approach
Authors: Ruales‐Carrera Edwin , Engler Madalena Lucia Pinheiro Dias , Vaz Paula , Özcan Mutlu , Volpato Claudia Angela Maziero
Published: November 2018

Objective

Congenital absence of maxillary lateral incisors is a frequent clinical challenge which must be solved by a multidisciplinary approach in order to obtain an esthetic and functional restorative treatment. Noninvasive treatments, that are in accordance with the patients' expectations, should be the first therapeutic alternative. If the deciduous tooth is present, minimally invasive dental extraction followed by immediate dental implant placement and provisional restoration is indicated. In this restorative treatment, an adequate emergency profile can be achieved by peri‐implant soft‐tissue‐conditioning techniques. Moreover, the association of restorative materials, such as composite resins and dental ceramics, provides more predictable esthetic results.

Clinical Considerations

The present case report presents a rehabilitation of bilateral congenital absence of maxillary lateral incisors through a multidisciplinary approach. Dental implants, long‐term provisional restoration, tooth bleaching, minimally veneered high‐translucent monolithic zirconia crowns, feldspathic veneers, and composite restorations were used by the dental team to achieve the expected functional and esthetic outcomes.

Conclusions

Different treatment modalities are available for the rehabilitation of congenital absence of teeth. However, it is important that a dental team consider performing minimally invasive treatments, as many of these treatments are done on young patients.

Clinical Significance

Patient‐centered treatments involving minimally invasive approaches in a multidisciplinary environment would be appropriate in order to achieve predictable results.
Serum sodium as a risk factor for hepatic encephalopathy in patients with cirrhosis and ascites
Authors: Bossen Lars , Ginès Pere , Vilstrup Hendrik , Watson Hugh , Jepsen Peter
Published: November 2018

Background and Aim

Hyponatremia is associated with development of hepatic encephalopathy (HE), but the nature of the relationship between serum sodium and HE incidence is unknown. We examined the association between serum sodium, changes in serum sodium, and HE incidence using data from three randomized trials of satavaptan in cirrhosis patients with ascites.

Methods

During follow‐up, patients were examined for HE, and serum sodium was measured regularly. We used fractional polynomials to estimate the nature of the association between current serum sodium and hazard rate of HE (e.g. with a linear, logarithmic, or exponential slope) and Cox regression to adjust for confounders. Moreover, we examined the association between serum sodium at inclusion and 30‐day and 1‐year cumulative risk of HE. Finally, we examined the effect of “change in serum sodium since inclusion” on the hazard rate of HE.

Results

We included 1116 patients of whom 302 developed HE. Median serum sodium at inclusion was 137 (interquartile range, 134–139). The lower the current serum sodium, the higher the rate of HE. Specifically, the confounder‐adjusted HE hazard rate increased linearly by 8% (adjusted hazard ratio = 1.08, 95% confidence interval: 1.06–1.10) for every mmol/L decrease in serum sodium over the range of measured values. Current serum sodium had a stronger effect on the HE rate than the changes in serum sodium since inclusion.

Conclusion

The hazard rate of HE development increased by 8% for every mmol/L decrease in serum sodium. Further, current serum sodium had a stronger effect on the HE rate than changes in serum sodium.
A Feminist Catholic Response to the Social Sin of Rape Culture
Authors: McCabe Megan K.
Published: November 2018

Despite pervasive sexual violence against women, especially the extensive problem of rape on college campuses, there is virtually no Catholic response. This paper seeks to fill this lacunae by examining campus rape culture as an instance of social sin. Within this sinful social reality, rape is not deviant, but is the extreme manifestation of gender norms and expectations that construct femininity as sexual availability and masculinity as sexual aggression and dominance. Participation in the sin of rape culture may range from actions of student and administrative bystanders to the everyday and mundane way that individuals live their gendered and sexual selves. In response, I offer three theological resources for moving toward transformation of rape culture into one that fosters the full human flourishing of all: interruption, conscience, and solidarity.
Not Far from the Kingdom: Martha Nussbaum on Anger and Forgiveness
Authors: Jackson Timothy P.
Published: November 2018

In Anger and Forgiveness, Martha Nussbaum offers a magisterial brief against what she calls “retribution” and “garden‐variety anger.” She does not write as a Christian, but there is much for a Christian ethicist to admire in her learned and creative treatment of moral emotion, including her defense of generosity. Professor Nussbaum is not far from the kingdom of God. I argue, nevertheless, that she blurs or erodes four important distinctions, between justice and love, anger and hatred, retribution and revenge, and utility and sanctity. The upshot is that her call for compassion degenerates into injustice. To justify this appraisal, I lay out Nussbaum’s normative case, identify three major theoretical difficulties with that case, examine briefly the teachings of Socrates and Jesus in relation to revolutionary justice, then note an admitted complexity.
Relationship between cobalamin and folate deficiencies and anemia in dogs
Authors: Stanley Emma , Appleman Elizabeth , Schlag Ariel , Siegel Andrea
Published: November 2018

Background

Megaloblastic, nonregenerative anemia is a well‐known consequence of cobalamin or folate deficiencies in humans but is not recognized in hypocobalaminemic or hypofolatemic dogs. Establishment of relationships between hypocobalaminemia or hypofolatemia and hematologic disease would encourage vitamin B testing, and potentially supplementation, in anemic dogs.

Objectives

To determine the prevalence of anemia in hypocobalaminemic or hypofolatemic dogs and to report the prevalence of hypocobalaminemia and hypofolatemia and nonregenerative anemia, macrocytosis, and anisocytosis in anemic dogs.

Animals

One hundred and fourteen client‐owned dogs with known serum cobalamin and folate concentrations and CBCs and 42 client‐owned anemic dogs.

Methods

Retrospective comparison of anemia prevalence in hypocobalaminemic or hypofolatemic and normocobalaminemic or normofolatemic dogs was performed. Prospective measurement of erythrocyte variables and cobalamin and folate concentrations in anemic dogs was carried out; relationships among hypocobalaminemia and regenerative status, mean corpuscular volume, and red cell distribution width were evaluated.

Results

Significant differences in prevalence of anemia between hypocobalaminemic (36%) and normocobalaminemic dogs (26%; P = .23) or between hypofolatemic (31%) and normofolatemic dogs (30%; P = .99) were not detected. Between hypocobalaminemic and normocobalaminemic dogs, no significant differences in prevalence of nonregenerative anemia (69% vs 63%; P = .65), macrocytosis (17% vs 0%; P = .53), or anisocytosis (28% vs 0%; P = .14) were detected. Anemic dogs had high prevalence of vitamin B deficiencies (nonregenerative: 64% hypocobalaminemic, 18% hypofolatemic; regenerative: 57% hypocobalaminemic, 21% hypofolatemic).

Conclusions and Clinical Importance

The association between cobalamin and folate deficiencies and macrocytic, nonregenerative anemia established in humans is not routinely present in dogs.
Management factors and clinical implications of glandular and squamous gastric disease in horses
Authors: Sykes Benjamin W. , Bowen Mark , Habershon‐Butcher Jocelyn L. , Green Martin , Hallowell Gayle D.
Published: November 2018

Background

To date, risk factors for equine glandular gastric disease (EGGD) have not been described in Thoroughbred racehorses.

Objectives

To determine management factors associated with EGGD, identify clinical signs in affected horses, and compare these to equine squamous gastric disease (ESGD).

Animals

The study was carried out on 109 Thoroughbred racehorses from 8 training yards (3 in the United Kingdom and 5 in Australia).

Methods

Gastroscopic examination alongside a questionnaire regarding management, feeding, exercise, and health.

Results

Management factors and clinical signs were different for EGGD versus ESGD. Exercising ≥5 days per week was associated with a 10.4 times (95% CI [confidence interval]: 1.34‐26.9) increased risk of EGGD. Horses racing below expectation were 3.7 times (95% CI: 1.1‐16.7) more likely to have EGGD. Trainer was also identified as a risk factor for EGGD. Time in work ≤6 weeks was associated with a decreased risk of ESGD (odds ratio [OR] 0.3; 95% CI: 0.1‐0.99). Horses aggressive to humans were less likely to have ESGD (OR 0.12; 95% CI: 0.03‐0.54). Horses with stereotypies were more likely to have ESGD (OR 5.0; 95% CI: 1.6‐15.9).

Conclusions and Clinical Importance

The findings of our study further support the notion that EGGD should be considered as a distinct disease entity to ESGD. Exercising ≤4 days per week could reduce the risk of EGGD. Horses with EGGD are more likely to perform below expectation and, as such, EGGD might be performance limiting in some affected individuals. Stress minimization could reduce the risk of EGGD.
Clinical features of canine pulmonary veno‐occlusive disease and pulmonary capillary hemangiomatosis
Authors: Reinero Carol R. , Jutkowitz L. Ari , Nelson Nathan , Masseau Isabelle , Jennings Samuel , Williams Kurt
Published: November 2018

Background

Histologic features of pulmonary veno‐occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) have been described in dogs but without a thorough clinical description.

Objectives

To report the clinical features, diagnostics, treatment, and outcome of dogs with histologic evidence of PVOD and PCH.

Animals

Fifteen pet dogs meeting histopathologic criteria of PVOD (occlusive remodeling of small‐sized to medium‐sized pulmonary veins) or PCH (alveolar capillary proliferation and congestion), or both.

Methods

Medical records of dogs with PVOD and PCH identified based on histopathologic features between 2003 and 2017 were retrospectively reviewed.

Results

Fifteen dogs met inclusion criteria of a histologic diagnosis of PVOD or PCH or both. Dogs were older (median 11 years) with no apparent breed or sex predisposition. Dogs presented with acute clinical signs (median 3 days), usually respiratory distress. Thoracic radiography (available in 10 dogs) revealed right cardiomegaly and patchy or diffuse interstitial to alveolar patterns, with 9 dogs having a normal left cardiac silhouette. In 5 dogs tested, pulmonary arterial hypertension (PAH) was documented. In all 3 dogs, thoracic computed tomography scans showed pulmonary arterial enlargement and perivascular diffuse nodular ground‐glass opacities. Ten of 15 dogs died within 1 day; median survival was 3 days.

Conclusions and Clinical Importance

In dogs with PAH, the inability to document left‐sided congestive heart failure and failure to identify another cause of signs of respiratory disease should increase suspicion for PVOD and PCH. With increased awareness of PVOD and PCH by clinicians and pathologists, dogs with compatible clinicopathologic features should be evaluated for these pulmonary vascular disorders.
Outcome and complications in goats treated by perineal urethrostomy for obstructive urolithiasis: 25 cases (2010‐2017)
Authors: Oman Rachel E. , Reppert Emily J. , Streeter Robert N. , Jones Meredyth
Published: November 2018

Background

Obstructive urolithiasis commonly affects male goats. Perineal urethrostomy (PU) can be a permanent treatment option but is generally considered undesirable because of the risk of stricture of the urethral stoma. Limited information exists regarding long‐term outcome and complications in goats undergoing PU for treatment of obstructive urolithiasis.

Objectives

To determine short‐term and long‐term outcome and complications in goats undergoing PU for treatment of obstructive urolithiasis.

Animals

Twenty‐five client‐owned goats.

Methods

Multi‐institutional retrospective case series.

Results

Of the 25 goats, 13 (52%) were alive at the time of follow‐up. Mean time from surgery to follow‐up was 34 months (range, 4‐65). Nine goats (36%) died between discharge and follow‐up with a mean survival time of 46 days (range, 5‐120). Cause of death in 7 of 9 (78%) goats was related to urolithiasis. Goats treated by use of a modified proximal perineal urethrostomy (MPPU) were significantly more likely to survive at least 150 days postoperatively (P < .01). The most common postoperative complications were hemorrhage (10/25 [40%]) and surgical site infection (3/25 [12%]). Hemorrhage was significantly associated with MPPU (P < .0001). Stricture of the surgical stoma occurred in 7 of 22 (32%) discharged goats. Mean time to stricture was 65 days (range, 10‐240).

Conclusions and Clinical Importance

Perineal urethrostomy can provide effective long‐term resolution of obstructive urolithiasis in goats. Re‐obstruction or stricture seems most likely within the 1st 2 months after surgery. MPPU may provide better long‐term results but should be approached cautiously because it can be associated with life‐threatening hemorrhage.
Community management of acute malnutrition (CMAM) programme in Pakistan effectively treats children with uncomplicated severe wasting
Authors: Aguayo Víctor M. , Badgaiyan Nina , Qadir Syed Saeed , Bugti Ali Nasir , Alam Muhammad Mazhar , Nishtar Noureen , Galvin Melanie
Published: November 2018

Severe wasting is the most widespread form of severe acute malnutrition, affecting an estimated 17 million children globally. This analysis assesses the effectiveness of Pakistan's community management of acute malnutrition (CMAM) programme. We conducted a retrospective case series analysis of 32,458 children aged 6–59 months who were admitted to the programme with a mid‐upper arm circumference (MUAC) < 115 mm (January 1–December 31, 2014). We found that at admission, 59.6% of the children were girls and 87.4% were in the age group 6–23 months old. While in the programme, 120 children (0.4%) died, 3,456 (10.6%) defaulted, and 28,882 (89.0%) were discharged after a mean length of stay of 69.3 ± 25.7 days. Children's mean weight gain while in the programme was 3.2 ± 2.7 g/kg body weight/day. At discharge, 28,499 children (98.7% of discharged) had recovered (MUAC ≥ 125 mm). The odds of death were significantly higher among children with weight‐for‐height (WHZ) < −3 and/or height‐for‐age (HAZ) < −2 at admission. The odds of recovery on the basis of MUAC ≥125 mm were higher among children with HAZ ≥ −2 at admission. The odds of recovery on the basis of WHZ ≥ −2 were significantly higher among children with WHZ ≥ −3 and/or HAZ < −2 at admission. Pakistan's CMAM programme is effective in achieving good survival and recovery rates. Population‐level impact could be increased by giving priority to children 6–23 months old and children with multiple anthropometric failure and by scaling up CMAM in the provinces and areas where the risk, prevalence, and/or burden of severe acute malnutrition is highest.
Birthweight and feeding practices are associated with child growth outcomes in South Asia
Authors: Harding Kassandra L. , Aguayo Víctor M. , Webb Patrick
Published: November 2018

Although there has been a focus on preventing stunting over the past decade, wasting has received less policy and programmatic attention. Recent national surveys from six South Asian countries were pooled to generate a dataset of 62,509 children aged 0 to 59 months to explore associations between low birthweight (LBW) and suboptimal infant and young child feeding (IYCF) practices with child wasting, severe wasting, and the co‐occurrence of wasting and stunting. Logistic regression models accounted for the surveys' clustered designs and adjusted for a potential confounding factors. Children with reported LBW had significantly higher odds of being wasted (adjusted odds ratio [95% CI]: 1.60 [1.45, 1.76]) or severely wasted (1.57 [1.34, 1.83]), compared with non‐LBW children. Similarly, children aged 0 to 23 months who were not breastfed within the first hour post‐partum, those who were provided prelacteal feeds, and those aged 0 to 5 months who were not exclusively breastfed, were more likely to be wasted (P < 0.05 for all three feeding practices). In India, not achieving minimum diet diversity and minimum adequate diet were significantly associated with the co‐occurrence of stunting and wasting. In other words, many key domains of concern to development agents who seek to address stunting are also of direct concern to those focused on wasting. The co‐occurrence of wasting and stunting requires more integrated interventions. That is, programmes aimed at preventing LBW and poor IYCF to avert stunting should be linked more effectively with actions aimed at the management of wasting.
Association between stunting and early childhood development among children aged 36–59 months inSouth Asia
Authors: Kang Yunhee , Aguayo Víctor M. , Campbell Rebecca K. , West Keith P.
Published: November 2018

Stunting (length‐for‐agezscore < −2) before 2 years of age has shown associations with poor child developmental indicators, but information at the population level is scarce in South Asia, the region with the highest burden of stunting. We examined associations betweenzscores (i.e., height for age [HAZ], weight for age [WAZ], and weight for height [WHZ]) and undernutrition (i.e., stunting [HAZ < −2], wasting [WHZ < −2], and underweight [WAZ < −2]) with learning/cognition and social–emotional development among children 36–59 months of age. Data fromMultiple Indicator Cluster Surveysin Bangladesh (n = 8,659), Bhutan (n = 2,038), Nepal (n = 2,253), and Pakistan (Punjabn = 11,369 and Sindhn = 6,718) were used. Children were considered developmentally “on‐track” in learning/cognition or social–emotional domains if they met specific early child development criteria. Meta‐analysis was conducted to examine regional associations, adjusting for socio‐economic status, early childhood education, and quality of care. In a pooled sample, on‐track learning/cognition development was positively associated with HAZ (OR = 1.17, 95% CI [1.07, 1.27]) and WAZ (OR = 1.18, 95% CI [1.07, 1.31]) and negatively associated with stunting (OR = 0.72, 95% CI [0.60, 0.86]) and underweight (OR = 0.75, 95% CI [0.66, 0.86]) but not associated with WHZ or wasting. On‐track development of social–emotional domain was not associated with anyzscores or undernutrition indicators. Across several countries of South Asia, stunted children were less likely to be developmentally “on track” for learning/cognition. It is likely that interventions that prevent stunting may benefit child development, leading to significant individual and societal gains given the large burden of child stunting in regions like South Asia.
Predictors of complementary feeding practices in Afghanistan: Analysis of the 2015 Demographic and Health Survey
Authors: Na Muzi , Aguayo Víctor M. , Arimond Mary , Mustaphi Piyali , Stewart Christine P.
Published: November 2018

Despite improvements over the past 20 years, high burdens of child mortality and undernutrition still coexist in Afghanistan. Global evidence indicates that complementary feeding (CF) practices predict child survival and nutritional status. Our study aims to describe CF practices in Afghanistan and to discern underlying predictors of CF by analysing data from Afghanistan's 2015 Demographic and Healthy Survey. Multilevel models were constructed comprising potential predictors at individual, household, and community levels and four CF indicators: timely introduction of solid, semi‐solid, or soft foods (INTRO), minimum meal frequency (MMF), minimum dietary diversity (MDD), and minimum acceptable diet (MAD) among breastfed children. INTRO prevalence among children aged 6–8 months was 56%, whereas the prevalence of MMF, MDD, and MAD among children aged 6–23 months was 55%, 23%, and 18%, respectively. Of the seven food groups considered, four were consumed by 20% or fewer children: eggs (20%), legumes and nuts (18%), fruits and vegetables (15%), and flesh foods (14%). Increasing child age and more antenatal care visits were significantly and positively associated with greater odds of meeting all CF indicators. Lower household wealth and lower community‐level access to health care services were associated with lower odds of MDD and MAD. Disparities in achieving recommended CF practices were observed by region. CF practices in Afghanistan are poor and significant socioeconomic inequities in CF are observed across the country. Our study calls for urgent policy and programme attention to improve complementary feeding practices as an intrinsic part of the national development agenda.
Effectiveness of programme approaches to improve the coverage of maternal nutrition interventions in South Asia
Authors: Goudet Sophie , Murira Zivai , Torlesse Harriet , Hatchard Jennifer , Busch‐Hallen Jennifer
Published: November 2018

The nutritional status of women before pregnancy, during pregnancy, and after delivery has far reaching consequences for maternal health and child survival, growth, and development. In South Asia, the high prevalence of short stature, thinness, and anaemia among women of reproductive age underlie the high prevalence of child undernutrition in the region, whereas overweight and obesity are rising concerns. A systematic review of evidence (2000–2017) was conducted to identify barriers and programme approaches to improving the coverage of maternal nutrition interventions in the region. The search strategy used 13 electronic bibliographic databases and 14 websites of development and technical agencies and identified 2,247 citations. Nine studies conducted in Bangladesh (n = 2), India (n = 5), Nepal (n = 1), and Pakistan (n = 1) were selected for the review, and outcomes included the receipt and consumption of iron and folic acid and calcium supplements and the receipt of information on dietary intake during pregnancy. The studies indicate that a range of barriers acting at the individual (maternal), household, and health service delivery levels affects intervention coverage during pregnancy. Programme approaches that were effective in improving intervention coverage addressed barriers at multiple levels and had several common features: use of formative research and client assessments to inform the design of programme approaches and actions; community‐based delivery platforms to increase access to services; engagement of family members, as well as pregnant women, in influencing behavioural change; actions to improve the capacity, supervision, monitoring, and motivation of front‐line service providers to provide information and counselling; and access to free supplements.
Aiming higher for maternal and child nutrition in South Asia
Authors: Torlesse Harriet , Aguayo Víctor M.
Published: November 2018

The sustainable development of nations relies on children developing to their full potential and leading healthy, productive, and prosperous lives. Poor nutrition in early life threatens the growth and development of children, especially so in South Asia, which has the highest burdens of stunting, wasting, and anaemia in the world. Targeted actions to reduce stunting and other forms of child malnutrition in South Asia should be informed by an understanding of what drives poor nutrition in children, who is most affected, and effective programme approaches. To this end, the UNICEF Regional Office for South Asia commissioned a series of papers in 2016–2017 to fill knowledge gaps in the current body of evidence on maternal and child nutrition in South Asia, including analyses of: (a) the links between anthropometric failure in children and child development; (b) the time trends, current distribution, disparities and inequities of child stunting, wasting and anaemia, and their direct and underlying causes, including maternal anaemia, low birth weight, breastfeeding, and complementary feeding; (c) policy and programme actions to increase the coverage of nutrition interventions during pregnancy, improve breastfeeding practices, and care for severely wasted children. This overview paper summarizes the evidence from these analyses and examines the implications for the direction of future advocacy, policy, and programme actions to improve maternal and child nutrition in South Asia.
The validity and reliability of the Dietary Index for a Child's Eating in 2–8‐year old children living in New Zealand
Authors: Delshad Maryam , Beck Kathryn L. , von Hurst Pamela R. , Mugridge Owen , Conlon Cathryn A.
Published: November 2018

This study aimed to examine the validity and reliability of the Dietary Index for a Child's Eating (DICE) in children living in New Zealand (NZ). Caregivers of healthy children aged 2–8 years completed a 4‐day estimated food record (4DFR) for their child and completed the DICE online on two separate occasions, 8 weeks apart. Relative validity was assessed by comparing the DICE and 4DFR total score and component subscores using the Wilcoxon test, Spearman rank correlation coefficients, cross‐classification, and weighted kappa (ĸ) statistic. For evaluating construct validity, the DICE total score was compared with energy and nutrient intake from the 4DFR using linear contrast analysis. Intraclass correlation coefficients (Cronbach's α) and Bland–Altman plots were used to assess the reliability of DICE. From a possible score of 100, the mean ± standard deviation of DICE was 78.2 ± 11.5 and from the 4DFR, was 73.8 ± 10.8, with a positive correlation (r = 0.72;p < 0.001) and moderate agreement (ĸ = 0.49). Cross‐classification showed 61.9% were correctly categorised into the same tertile group from DICE and the 4DFR. Participants in the highest tertile of DICE had higher intakes of fibre, vitamin C, vitamin A, vitamin D, folate, and calcium. Good agreement (α = 0.87) was found for reliability. DICE is a valid and reliable tool for the assessment of children's adherence to a healthy diet, as recommended by the NZ Ministry of Health Food and Nutrition guidelines.
The Ralstonia solanacearum effector RipN suppresses plant PAMP‐triggered immunity, localizes to the endoplasmic reticulum and nucleus, and alters the NADH/NAD+ ratio in Arabidopsis
Authors: Sun Yunhao , Li Pai , Shen Dong , Wei Qiaoling , He Jianguo , Lu Yongjun
Published: November 2018

Ralstonia solanacearum, one of the most destructive plant bacterial pathogens, delivers an array of effector proteins via its type III secretion system for pathogenesis. However, the biochemical functions of most of these proteins remain unclear. RipN is a type III effector with unknown function(s) from the pathogen R. solanacearum. Here, we demonstrate that RipN is a conserved type III effector found within the R. solanacearum species complex that contains a putative Nudix hydrolase domain and has ADP‐ribose/NADH pyrophosphorylase activity in vitro. Further analysis shows that RipN localizes to the endoplasmic reticulum (ER) and nucleus in Nicotiana tabacum leaf cells and Arabidopsis protoplasts, and truncation of the C‐terminus of RipN results in a loss of nuclear and ER targeting. Furthermore, the expression of RipN in Arabidopsis suppresses callose deposition and the transcription of pathogen‐associated molecular pattern (PAMP)‐triggered immunity (PTI) marker genes under flg22 treatment, and promotes bacterial growth in planta. In addition, the expression of RipN in plant cells alters NADH/NAD+, but not GSH/GSSG, ratios, and its Nudix hydrolase activity is indispensable for such biochemical function. These results suggest that RipN acts as a Nudix hydrolase, alters the NADH/NAD+ ratio of the plant and contributes to R. solanacearum virulence by suppression of PTI of the host.
A systematic screen of conserved Ralstonia solanacearum effectors reveals the role of RipAB, a nuclear‐localized effector that suppresses immune responses in potato
Authors: Zheng Xueao , Li Xiaojing , Wang Bingsen , Cheng Dong , Li Yanping , Li Wenhao , Huang Mengshu , Tan Xiaodan , Zhao Guozhen , Song Botao , Macho Alberto P. , Chen Huilan , Xie Conghua
Published: November 2018

Both Solanum tuberosum and Ralstonia solanacearum phylotype IIB originated in South America and share a long‐term co‐evolutionary history. However, our knowledge of potato bacterial wilt pathogenesis is scarce as a result of the technical difficulties of potato plant manipulation. Thus, we established a multiple screening system (virulence screen of effector mutants in potato, growth inhibition of yeast and transient expression in Nicotiana benthamiana) of core type III effectors (T3Es) of a major potato pathovar of phylotype IIB, to provide more research perspectives and biological tools. Using this system, we identified four effectors contributing to virulence during potato infection, with two exhibiting multiple phenotypes in two other systems, including RipAB. Further study showed that RipAB is an unknown protein with a nuclear localization signal (NLS). Furthermore, we generated a ripAB complementation strain and transgenic ripAB‐expressing potato plants, and subsequent virulence assays confirmed that R. solanacearum requires RipAB for full virulence. Compared with wild‐type potato, transcriptomic analysis of transgenic ripAB‐expressing potato plants showed a significant down‐regulation of Ca2+ signalling‐related genes in the enriched Plant–Pathogen Interaction (PPI) gene ontology (GO) term. We further verified that, during infection, RipAB is required for the down‐regulation of four Ca2+ sensors, Stcml5, Stcml23, Stcml‐cast and Stcdpk2, and a Ca2+ transporter, Stcngc1. Further evidence showed that the immune‐associated reactive oxygen species (ROS) burst is attenuated in ripAB transgenic potato plants. In conclusion, a systematic screen of conserved R. solanacearum effectors revealed an important role for RipAB, which interferes with Ca2+‐dependent gene expression to promote disease development in potato.
Can intravenous antifungal therapy be safely used in the outpatient parenteral antimicrobial therapy (OPAT) setting?
Authors: Rae Nikolas , Kenny Claire , Muldoon Eavan G.
Published: November 2018

Outpatient parenteral antimicrobial therapy (OPAT) is an established treatment option for patients with a variety of infections who require a period of intravenous therapy, are clinically stable, and do not require continuous monitoring. Many patients with fungal infections require prolonged therapy due to resistance or intolerance to oral antifungal agents. Despite the widespread use of OPAT by infection specialists, antifungal agents appear infrequently used in this setting. We suggest that with appropriate patient selection, patients with fungal infections could successfully be treated on OPAT.
Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury
Authors: Meneses Gabriela , Cárdenas Graciela , Espinosa Alejandro , Rassy Dunia , Pérez‐Osorio Ivan Nicolás , Bárcena Brandon , Fleury Agnes , Besedovsky Hugo , Fragoso Gladis , Sciutto Edda
Published: November 2018

Sepsis occurs when a systemic infection induces an uncontrolled inflammatory response that results in generalized organ dysfunction. The exacerbated peripheral inflammation can induce, in turn, neuroinflammation which may result in severe impairment of the central nervous system (CNS). Indeed, the ensuing blood–brain barrier disruption associated with sepsis promotes glial activation and starts a storm of proinflammatory cytokines in the CNS that leads to brain dysfunction in sepsis survivors. Endotoxic shock induced in mice by peripheral injection of lipopolysaccharides closely resembles the peripheral and central inflammation observed in sepsis. In this review, we provide an overview of the neuroinflammatory features in sepsis and of recent progress toward the development of new anti‐neuroinflammatory therapies seeking to reduce mortality and morbidity in sepsis survivors.
The singular properties of photosynthetic cytochrome c550 from the diatom Phaeodactylum tricornutum suggest new alternative functions
Authors: Bernal‐Bayard Pilar , Álvarez Consolación , Calvo Purificación , Castell Carmen , Roncel Mercedes , Hervás Manuel , Navarro José A.
Published: November 2018

Cytochrome c550 is an extrinsic component in the luminal side of photosystem II (PSII) in cyanobacteria, as well as in eukaryotic algae from the red photosynthetic lineage including, among others, diatoms. We have established that cytochrome c550 from the diatom Phaeodactylum tricornutum can be obtained as a complete protein from the membrane fraction of the alga, although a C‐terminal truncated form is purified from the soluble fractions of this diatom as well as from other eukaryotic algae. Eukaryotic cytochromes c550 show distinctive electrostatic features as compared with cyanobacterial cytochrome c550. In addition, co‐immunoseparation and mass spectrometry experiments, as well as immunoelectron microscopy analyses, indicate that although cytochrome c550 from P. tricornutum is mainly located in the thylakoid domain of the chloroplast – where it interacts with PSII – , it can also be found in the chloroplast pyrenoid, related with proteins linked to the CO2 concentrating mechanism and assimilation. These results thus suggest new alternative functions of this heme protein in eukaryotes.
Bottom‐Up Identification of Subsystems in Complex Governance Systems
Authors: Angst Mario
Published: November 2018

Theories of policymaking often focus on subsystems within a larger, overarching governance system. However, subsystem identification is complicated by the complexity of governance systems, characterized by multiple, interrelated issues, multi‐level interactions, and a diverse set of organizations. This study suggests an empirical, bottom‐up methodology to identify subsystems. Subsystems are identified based on bundles of similar observed organizational activity. The study further suggests a set of three elementary criteria to classify individual subsystems. In order to prove the value of the methodology, subsystems are identified through cluster analysis, and subsequently classified in a study of Swiss water governance. Results suggest that Swiss water governance can be understood as a network of overlapping subsystems connected by boundary penetrating organizations, with high‐conflict and quiet politics subgroups. The study shows that a principled analysis of subsystems as the interconnected, constituent parts of complex governance systems offers insights into important contextual factors shaping outcomes. Such insights are prerequisite knowledge in order to understand and navigate complex systems for researchers and practitioners alike.
Nutrition and Feeding Aspects for Jundiá (Rhamdia quelen) Rhamdia quelen Nutrition and Feeding
Authors: Santos Hanna Karolyna dos , Meurer Fabio
Published: November 2018

The jundiá or silver catfish (Rhamdia quelen Quoy & Gaimard, 1824) is species native to the Americas, omnivorous, with a tendency towards carnivorous feeding habits. The species presents commercial potential, and therefore, knowledge on its nutritional requirements, as well as basic feed ingredients, is essential. Its tendency towards carnivorous feeding habits leads to some concerns regarding plant ingredient digestion abilities, although rice, soybean, flax, sorghum, ground corn or oat bran can be used as feed ingredients for this species, since they present good digestibility coefficients. In order to guarantee adequate performance of metabolic, immunological and reproductive functions, jundiá feed can be supplemented with micronutrients that minimize the effects of antinutritional factors present in plant ingredients. Plant ingredients present several economic advantages such as suitable quality, competitive prices and the fact that they are widely available in South Brazil.
Civil society contributions to local level flood resilience: Before, during and after the 2015 Boxing Day floods in the Upper Calder Valley
Authors: Forrest Steven , Trell Elen‐Maarja , Woltjer Johan
Published: November 2018

There is an increasing emphasis on the local level as well as growing expectations regarding civil society actors in flood‐risk management in the UK. However, not enough is known about the potential contributions of civil society to flood resilience at the local level. This paper addresses this knowledge gap by conceptualising flood resilience at the local level across three phases inherent to flood disasters: pre‐flood, during the flood and post‐flood. These phases act as the foundation for this paper's exploration of the contributions of civil society to local‐level flood resilience. Data were collected before, during and after the 2015 Boxing Day floods through interviews (in 2015 and 2017) and from secondary data sources. The paper identifies the importance of time and place when analysing civil society contributions to local level flood resilience. These contributions were dynamic over time with a strong initial response that diminished over time due to apathy, “active forgetting” and lack of further exposure. Exposure and a sense of community strongly influenced civil society contributions to flood resilience in the Upper Calder Valley. Issues of representation and varying place‐based capacities were also identified as relevant for flood resilience‐based policies. These results have larger implications for our understanding of the contributions of civil society actors to flood resilience and suggest that while they can deliver better local context‐specific approaches, there needs to be caution over the long‐term sustainability and longevity of their contributions.
High rate of seromarkers for HIV, HBV and syphilis among blood donors using confidential unit exclusion, before and after HIV‐NAT implementation at a major public blood bank in the Brazilian Amazon
Authors: Souza Janaina C. , Crispim Myuki A. E. , Abrahim Claudia , Fraiji Nelson A. , Kiesslich Dagmar , Stefani Mariane M. A.
Published: November 2018

BACKGROUND

Confidential unit exclusion (CUE) was introduced in the 1980's as an additional layer to blood safety, before highly specific and sensitive nucleic acid tests (NAT) for HIV were implemented. The utility of CUE‐use in settings that have implemented NAT should be evaluated over time.

STUDY DESIGN, METHODS

Cross‐sectional retrospective study carried out from June 2010–November 2015, at Manaus Hemocenter (HEMOAM), Amazonas, Brazil that implemented HIV‐NAT in 2012. The HIV, HCV, HBV, HTLV, Chagas disease, and syphilis rates were compared among CUE and non‐CUE blood donors, before and after HIV‐NAT implementation.

RESULTS

Among 287,588 donations, 2,154 (0.75%) were associated with CUE, mainly voluntary donations (64.2%), by repeat donors (58.4%) from young (median age = 31 years), males (84.4%), unmarried (63.1%). CUE‐users compared to non‐CUE donors (n = 285,434) had higher seropositivity rates to HIV (OR = 6.09, 95% CI: 3.68–10.07, p < 0.001), HBV (anti‐HBc OR = 1.81 95% CI: 1.24–2.64, p = 0.004; HBsAg OR = 5.68, 95% CI: 1.78–18.07, p = 0.017), and syphilis (OR = 1.78, 95% CI: 1.05–3.04, p = 0.030). Most (97.2%) discarded blood units associated to CUE was seronegative for all pathogens. Most donations (73.4%) were tested by HIV‐NAT and showed four window period donations, positive by HIV‐NAT only among non‐CUE donors.

CONCLUSION

A high rate of transfusion transmissible infections/TTIs was observed at HEMOAM especially in CUE‐users. CUE‐use offered an additional layer of blood safety by its association with anti‐HBc/HBsAg and syphilis that are not covered by NAT. For blood banks in highly endemic areas for HIV and TTI, as HEMOAM, the identification of at risk donors, and the orientation to be tested at proper sites remain a great challenge.
Hepatitis E virus in Common voles (Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae‐specific genotype of Orthohepevirus C
Authors: Kurucz Kornélia , Hederics Dávid , Bali Dominika , Kemenesi Gábor , Horváth Győző , Jakab Ferenc
Published: November 2018

Hepatitis E virus is a major causative agent of acute hepatitis worldwide. Despite its zoonotic potential, there is limited information about the natural chain of hepevirus infection in wildlife, and the potential reservoir species. In this study, we performed a HEV survey by heminested RT‐PCR on rodent samples from an urban environment (in the city of Pécs, Hungary) and investigated the prevalence of the virus among these native rodent species (Apodemus agrarius, Apodemus flavicollis, Apodemus sylvaticus, Microtus arvalis and Myodes glareolus). HEV was detected exclusively in Common voles (M. arvalis), in 10.2% of screened voles, and 3.2% of all investigated samples from all species. Based on the phylogenetic analysis, our strain showed the closest homology with European Orthohepevirus C strains detected previously in faecal samples of birds of prey and Red fox, supporting the possibility of the dietary origin of these strains. In addition, our samples showed close phylogenetic relation with a South American strain detected in Necromys lasiurus (Cricetidae), but separated clearly from other Muridae‐associated strains, suggesting the presence of a Cricetidae‐specific genotype in Europe and South‐America. Based on these results, we hypothesize the reservoir role of M. arvalis rodents for the European Cricetidae‐specific Orthohepevirus C genotype.
A Cross-National Analysis of Parent Involvement in Decision-Making: Germany, France and Turkey
Authors: Gülcan Murat Gürkan , Duran Ali
Published: November 2018

Being a cross-national analysis, the aim of this study, which draws on data from school principals, is to evaluate parents’ involvement in decision-making processes comparatively in Turkey, Germany and France, which are members of the Organization for Economic Cooperation and Development (OECD) and were included in the study in terms of some variables, such as data in Human Development Index (HDI) report 2016 and results of the Programme for International Student Assessment (PISA) 2015 reading skills, math and science literacy results’ based on demographic, socio-economic, socio-cultural variables as well as achievements in education, population trends and parents’ involvement in education. Phenomonology research design from qualitative research methods was used in this study. Data analyses relied on content analysis technique. School administrators from Turkey, Germany and France were included through criteria sampling method from purposeful sampling methods. Interview technique was employed in order to collect data through a semi-structured interview form. The findings of the study highlighted that all participants agree on the positive impact of parents’ involvement in decision-making but there are some ambiguity how and what level parents must involve in decision-making processes. Some recommendations are made on how to improve involvement in decision-making process.
Perfect food: perspectives on consumer perceptions of fresh produce quality
Authors: Finlayson Caitlin
Published: November 2018

Over the past century, the global food system has largely shifted from a localized, decentralized agricultural model to more centralized, industrial food production system. Corresponding with this shift was a change in consumer preferences, an expectation for “perfect” fruits and vegetables that has contributed to a significant problem with wasted food. An alternative food system, aimed at providing locally-grown, sustainable produce has countered this model and has sought to reconnect consumers and producers. At the same time, this alternative model still exists within a larger agricultural system dominated by industrial production and standardization. This paper examines how the changes in the ways consumers look at fresh produce quality has affected the practices of retailers and drives food waste at the supply chain using in-depth interviews conducted in a variety of settings in Fredericksburg, Virginia, USA. An analysis of these interview findings reveals that even in alternative food buying locations, consumers have a general expectation of perfection but that as consumers build relationships with the people who grow their food, these perceptions, and our food waste practices, might be changed.
Studying brownfields: governmentality, the post-political, or non-essential materialism?
Authors: Conroy William
Published: November 2018

This paper sets out to evaluate several common theoretical frameworks employed in critical studies of brownfield redevelopment. Specifically, it analyzes the relevance of governmentality, the post-political, and non-essentialist materialism in that context. To do so, it explores how these theoretical frameworks map on to Bridgeport, Connecticut’s BGreen 2020, and its approach to the redevelopment of vacant and underutilized land – and brownfields more specifically. It argues that these frameworks come up short when applied to this empirical case because they put forth untenable ontological claims regarding the constitution of the subject and political agency. Going further, it asserts that these frameworks fail to identify a way forward for those seeking emancipatory political interventions in the context of brownfield redevelopment and urban environmental politics. In closing this paper suggests that Jason W. Moore's recent writing on “capitalism as world-ecology” can provide a way forward where these other frameworks fail.