bluuebunny/crossref_metadata_2025 huggingface dataset:
Mengungkap Dimensi Pemaknaan Hunian
Authors: Hutomo Cahyo S. , Kusuma Hanson E.
Published: June 2022

Urbanization is increasing the need for and building sites and vertical housing. Changes in residential typology cause changes in housing preferences and meanings. This study aims to reveal the dimensions of residential meanings — the study conducted in two stages with a sequential mix-method. The first stage is qualitative research using an explorative grounded theory approach. The categories and variables identified in the first stage of the research are used in the second phase of research quantitatively using the correlational research approach. The data collected were analyzed by factor analysis to reveal the dimensions of residential meaning — the dimensions of the revealed mapping distinguished by the type of occupancy, namely site, and vertical dwelling. The vertical house tends to be perceived as having more social and physiological significance, personalization, tranquility, hiding, economy, and self-actualization than site occupancy.
Adaptasi Kinerja Bangunan Rumah Tinggal dengan Ventilasi Atap Responsif
Authors: Mufidah Mufidah , Purwanto LMF. , Sanjaya Ridwan
Published: June 2022

Thermal comfort is a condition where occupants can feel comfortable doing activities in the building. One of the ways to get comfort is done by passive design, in which the building is designed to adapt weather change outside the building. Because the weather outside is always changing, the planned building design must be responsive to these weather changes. This study uses a responsive roof ventilation model, that the movement of the roof vent covering grille, which serves as an attempt to regulate the exit of wind from the inlet. This study method begins with a literature review on the thermal comfort of residential building in the humid tropics, as a study of the application of passive design principles as building adaptation to weather changes. Furthermore, an analysis of the ventilation area is made based on the need for thermal comfort in the building. Finally, the planning of building performance systems automatically using the Arduino temperature and humidity sensors. The result is the concept of a framework as applying automation to responsive roof ventilation. This preliminary study is still basic and it is hoped that can be continued in research with the application and experimentation of the roofs in small building
Pengaruh Petuah bobeto Terhadap Kearifan Setempat Kampung Kalaodi, Kota Tidore Kepulauan
Authors: Teng Ichsan Sukarno , Nugroho Agung Murti , Kusdiwanggo Susilo
Published: June 2022

Indigenous advice are one of the sources of local wisdom somewhere. Local wisdom becomes an important issue in sustainable environmental control. This research aims to analyze and explain the local wisdom of Kalaodi Village, Tidore Islands City which is influenced by Bobeto indigenous advice. The research method used is descriptive with the variables of village place, customary rules, collective memory and spatial system. The research procedure includes the stages: describing the topic of information related to advice and object selection; questioning matters related to advice through informants' memories; the decomposition of the information obtained becomes the focus of the problem; data collection and recording field data through observation and interviews; data analysis and writing the results. The results showed Bobeto indigenous advice to be the main factor influencing the local wisdom of Kalaodi Village, Tidore Islands City
Tata Spasial Permukiman Kasepuhan Sinar Resmi, Kabupaten Sukabumi, Jawa Barat
Authors: Mawaddahni Sari , Wulandari Lisa Dwi , Nugroho Agung Murti
Published: June 2022

Kasepuhan Sinar Resmi are part of the Banten Kidul Indigenous Community with a cultural base of rice in their lives. The settlements are formed from natural, geographic, socio-economic-cultural activities that have spatial characteristics. The spatial peculiarities of the settlement are interesting things to be studied and reveal their physical and philosophical manifestations. With a qualitative descriptive analysis approach, this study aims to identify and describe the characteristics of the Kasepuhan Sinar Resmi housing based on non-physical and physical aspects. The variables studied were: 1) socio-cultural and economic, 2) public activity, 3) natural and geographic conditions, 4) spatial-forming elements of settlements, 5) physical spatial layout, and 6) building typology. The results showed that the character of the settlement was formed based on non-physical aspects in the form of consistency in carrying out the tatali paranti karuhun, as well as respect and obedience to the leaders as regulator of life in kasepuhan. This is the main factor that greatly influences the spatial layout of the Kasepuhan Sinar Resmi’s settlement physically apart from the natural and geographical conditions of the area. The implementation of respect for karuhun is the continuity of the rice culture that has been preserved until now, which is sustainable in all farming activities, and the socio-culture of the kasepuhan community.
Membaca Intertekstualitas pada Hasil Renovasi Stasiun Jatinegara Jakarta
Authors: Puspitasari Mutiara Indah , Yusran Yusfan Adeputera , Titisari Ema Yunita
Published: June 2022

Jatinegara Station is considered as an A class station in Jakarta, which has been around for 111 years since it opened in 1909. This station has been redeveloped in terms of railway facilities and building infrastructure owing to the Double-doubled Track (DDT) project. This renovation attracts discourses in the topic of cultural heritage building’s sustainability, the functionality of the heritage building as an infrastructure building, and the compability of the new concourse building when being compared to the heritage building. Research based on intertextuality study is used to find reasons for development based on the historical and social aspects of today's society. The reasearch of intertextual relationship between the text of Jatinegara Station and the sociohistorical text can provide a further understanding on the renovation in the hope that the public could appreciate the renovations that has been carried out. The methodology used in this research is descriptive with a qualitative approach, the analysis will undergo through suprasegmental and intertextual technique provided by Julia Kristeva. The results is intertextuality reading of renovated Jatinegara Railway Station that is obtained through analyzing the sociohistoric text within.
Pemanfaatan Ruang Punden Pada Tradisi Nyadranan Desa Klepek Kabupaten Kediri
Authors: Tantyo Muhammad Andi Finaldi Nur , Wulandari Lisa Dwi , Nugroho Agung Murti
Published: June 2022

Local wisdom of Klepek village involves a sacred space called punden. The implementation of the tradition with punden as a sacred space is an embodiment of the inner responsibility and gratitude of the community to the ancestors who built the village. Traditional activities involving punden consist of the nyadranan tradition, barikan, preparation for celebrations and thanksgiving after harvest. The focus of this research is on the nyadranan tradition. This study uses a qualitative method. Data from the object of observation was studied descriptively. The belief of the people of Klepek Village who believe punden as a sacred place results in the use of space. With the use of space for sacred activities, it can also be seen the factors that form it, namely: activity, purpose, time and actors involved. The interaction of these factors with the space used shows the meaning of space.
Evaluasi Penerapan Green City Pada Taman Kota (Studi Kasus : Taman Kota Lumintang Denpasar)
Authors: Mahendra I Gede Indra , Dwijendra Ngakan Ketut Acwin
Published: June 2022

The sustainability of urban environmental development can be realized with the concept of a Green City or Green City. The application of Green City can be applied by structuring a city's green open space. The existence of green open space in Denpasar City has made the Denpasar City government begin to restore the Lumintang City Park as a solution to urban problems that arise. The government participates in the arrangement of Lumintang City Park so that it can be directed to become a Green City element that focuses more on evaluating green open space, green community, and green energy. The purpose of this study is to evaluate whether Denpasar City Park Lumintang has implemented the Green City aspect or not and the changes to Lumintang City Park will be directed towards which direction to address the growth of Denpasar City in the future. The method used is qualitative with a descriptive approach. Data was collected through interviews and observations regarding the evaluation of green open space, green community, and green energy. The results show that based on the application of green city to the three parameters used, the implementation of green open space and green community has been implemented but in its application, it has not been optimal while green energy has not been implemented at all. So it is necessary to have the attitude of the government and the community in the development of this grand city.
Preferensi dalam Memilih Hunian Menapak dan Vertikal oleh Generasi Y dan Z di Indonesia
Authors: Tang Angel , Kusuma Hanson E. , Riska Annisa Safira
Published: June 2022

The need for housing becomes important, especially for generations Y and Z who are dominating the world's population today. The type of dwelling itself is divided into tread dwelling and vertical dwelling. In determining the type of residence they want, someone always relates it to the criteria they want as well as generations Y and Z. This study aims to determine the preferences of generations Y and Z for the type of tread or vertical residence they want. The research uses a grounded theory approach with qualitative-exploratory methods. Data collection uses a questionnaire that is distributed online and is open-ended from a freely selected sample. The findings show that there are two types of housing that are possible for generations Y and Z, namely residential treads on the outskirts of the city and vertical housing in the city center. The reasons for choosing a residence on the outskirts of the city are: flexibility, convenience, value, environment, livable culture, and security. The reasons for choosing vertical housing in the city center are: location and accessibility, facilities, practicality, atmosphere, and compulsion.
Jack Holland’ın Mizojini: Dünyanın En Eski Önyargısı: Kadından Nefretin Evrensel Tarihi adlı eserinin değerlendirilmesi / Review of Mizojini: Dünyanın En Eski Önyargısı: Kadından Nefretin Evrensel Tarihi [A Brief History of Misogyny: The World’s Oldest Prejudice] by Jack Holland
Authors: Yıldız Saide Zehra
Published: June 2022

Jack Holland, Mizojini: Dünyanın En Eski Önyargısı: Kadından Nefretin Evrensel Tarihi (Erdoğan Okyay, Çev.) (2. Baskı, İstanbul: İmge Kitabevi Yayınları, 2019, 302 sayfa). ISBN: 978-975-533-844-6.
Minder bekende of verdwenen locaties in Gent: Groentemarkt De Grote (en De Kleine) Steur.
Authors: Van Ryssel Daniël
Published: June 2022

De Groentemarkt was vroeger vismarkt, wat de naam van het hier
besproken huis aan die markt verklaart. Pas sedert de 18de eeuw werden
er groenten verkocht, een nu al weer bijna verdwenen bedrijvigheid.
Reeds in 1400 werd het huis De Steur op de vismarkt vermeld. Kort nadien was er sprake van den Groten Steur. Dus moest er ook een Kleine Steur hebben bestaan... Tot op heden werd het huis herhaaldelijk opgesplitst en herenigd onder verschillende eigenaars.
De Heilige Antonius van de Zuidstatie
Authors: Andelhof Emiel
Published: June 2022

Een beschrijving ontleeend aan Emiel Andelhof’s Galerij van Gentsche Typen (1942)
Giele, de geernaardmarchand
Authors: Andelhof Emiel
Published: June 2022

Rond 1900 was Willem (Guillaume: Giele) Campens een graag geziene figuur. Iedere Gentenaar kende hem: een forse kerel met een grote neus en een korte baard, vriendelijke blik. ’s Zomers trok bij langs de straten in karakteristieke outfit: grote gele strohoed en donkere kiel die hem bijna tot de voeten reikte. Op een platte kruiwagen duwde hij zijn garnalenvoorraad voort.
Het echte Metselaarshuis in de Cataloniëstraat.
Authors: Redactie GT
Published: June 2022

Iets oudere Gentenaars hebben in de vorige eeuw het neringhuis van de metselaars, het Metselaarshuis op de hoek van de Cataloniëstraat en de Sint-Niklaasstraat, gekend in zeer vervallen toestand. Pas toen men in 1975 aanstalten maak te het huis te slopen, nam de stedelijke dienst voor monumentenzorg en archeologie initiatieven om het behoud veilig te stellen. 15 jaar later in 1989 begon men aan de restauratie die voltooid werd in 1991. De kenners fronsten de wenkbrauwen, maar dat was niets vergeleken met de ongewoon heftige polemiek rond de aanbouw in de Sint-Niklaasstraat met sterk contrasterende hedendaagse vormgeving
Middeleeuws begraven door Schokkebroers en Matewijven in Gent. Deel 3. Van lollaarden tot alexianen, van matevrouwen tot zwarte zusters.
Authors: Devriese Luc
Published: June 2022

In het derde en laatste deel van deze kleine reeks gaan we op zoek naar het ontstaan van de mannen- en vrouwengemeenschappen op de vest aan de Houtlei en knopen we vanaf de jaren 1500 aan met de latere evolutie, toen de broeders en zusters evolueerden tot streng geordende religieuze gemeenschappen.
Katrienspekken in het hof van Ravenstein aan Onderbergen
Authors: Devriese Luc
Published: June 2022

Het historische gebouwencomplex bekend in oorsprong een middeleeuws Steen, daarna als Hof van Ravenstein en in de vorige eeuw huis Ligy, waarin het onooglijke spekkenwinkeltje een plaatsje gevonden had, was in snel tempo aan het verloederen. De spekken bieden ons een gelegenheid om de geschiedenis en de bijna-doodstrijd van het pand even te bekijken. We schet sen dat in korte trekken en proberen ook te achterhalen hoe de Katrienspekken gemaakt werden.
Minder bekende Gentse fotografen. Dominique Aelterman. Opvolger van Nestor Schaffers.
Authors: Verhoosele Françoise
Published: June 2022

Dominique Aelterman (Laarne 1844-Gent 1904), opgeleid als schilder en fotograaf, was slechts zes jaar zelfstandig actief als opvolger van Ernest Schaffers
Gent bij de bevrijding in 1944: met de ‘steekkerre’ van ’t Stapelplein naar ’t Rabot.
Authors: Vermeirsch Eric
Published: June 2022

Bij de bevrijding probeerde de noodlijdende bevolking zich meester te
maken van wat in het havengebied opgestapeld stond ter bevoorrading
van de bezettende troepen. Dat gebeurde niet zelden met een stootkar, in
het Gents steekkerre, een met mankracht voortgeduwde houten kar.
Hier na volgt een zeer persoonlijk relaas van het gebeuren.
Kerkelijke concurrentie voor de Gentse benedictijnenabdijen (ca. 1200-1500). Deel 1. Nieuwe abdijen.
Authors: Hanson Marc
Published: June 2022

In de dertiende eeuw kenden de Sint-Baafsabdij en Sint-Pieters, grote financiële zorgen. De literatuur over beide abdijen legde de oorzaken van die problemen, geheel terecht, in het verkeerde beleid van die abdijen met hun vele hoge, onnodige uitgaven. Maar dat was de enige oorzaak niet: vanaf de dertiende eeuw kregen de twee Gentse, toen al bijna een half millennium oude stichtingen serieuze concurrentie van nieuwe orden en kloosters. Die concurrentie heeft hen pijn gedaan en hun financiële problemen wellicht nog versterkt.
Nog over 't Fortje.
Authors: De Kremer Raymond
Published: June 2022

Enkele verhaaltjes van Jean Ray die zich afspelen in de cité en de buurt van de Blaisantvest.
Oorlogsherinneringen (1944-1940) van een broekventje in en rond het Citadelpark
Authors: Mineur Ghislain
Published: June 2022

Een levendig verhaal van de oorlogsjaren zoals ervaren door een kind, geboren in 1932 en wonende bij het Gentse Citadelpark. Het vormt een welgekomen aanvulling bij de vele getuigenissen opgetekend door beroepshistorici, die vooral geïnteresseerd zijn in de politieke en militaire geschiedenis van W.O. II en de Duitse bezetting. Het verhaal werd pas in 2007-2009, vele jaren na de gebeurtenissen, klaarblijkelijk ‘uit het geheugen’
opgeschreven.
Kerkelijke concurrentie voor de Gentse benedictijnenabdijen (ca. 1200-1500). Deel 2. Nieuwe stedelijke kloosters.
Authors: Hanson Marc
Published: June 2022

In dit tweede deel wordt ingegaan op concurrenten van een heel ander type: de stedelijke kloosters. Die bezaten weinig of geen gronden, basis van rijkdom in de feodale samenleving. Mede daarom werden ze bedelorden en hun leden mendicanten genoemd.
Pareltjes uit het Begijnhof
Authors: Dousselaere Hans
Published: June 2022

Politieke strijd kommunistische partij te Gent. Strijd tegen dure leven 1954. Kostprijs internaat Sint Gregorius. Maison Universelle Veldstraat.
Hergebruik van kerken onder Keizerin Maria-Theresia. Volgens een schotschrift Lettre périodique d’un Hollandois rénommé à un négociant de considération établi en Flandres.
Authors: Devriese Luc
Published: June 2022

Het zoeken van nieuwe bestemmingen voor kerken en kapellen is actueel, maar het probleem dateert niet van gisteren of eergisteren. Een schotschrift leert ons dat dit al in de jaren 1700 in sommige kringen voor beroering zorgde. De tekst in briefvorm werd zogenaamd geschreven door een anonieme Hollander (in werkelijkheid een hoge ambtenaar in dienst van het Oostenrijkse bewind), en gericht aan een even anonieme achtenswaardige
Vlaamse handelaar. De briefschrijver heeft het niet alleen over het jezuïetenklooster en -kerk in het bouwblok tussen de huidige Universiteitstraat (toen Lange Meer) en Volderstraat, maar ook over de Sint-Niklaaskerk die zou omgevormd worden tot magazijn en markt.
De Gentse ‘Hollandse’ citadel in internationale context. Deel 1. Waarom Gent rond 1700 niet in de gordels van barrièresteden ingeschakeld werd, maar wel in de Wellingtonbarrière (1815-1830)
Authors: Hanson Marc
Published: June 2022

Waarom behoorde Gent rond 1700 niet tot de barrièresteden: de gordel van steden versterkt tegen het oorlogszuchtige Frankrijk? Waarom werd Gent wel opgenomen in de Wellingtonbarrière (1815-1830)? Waarom werden al die dure forten – Gent was zelfs zeer duur – toch nog gebouwd of weer opgeknapt, hoewel ze militair eigenlijk al een anachronisme waren?
A survey on aquatic animal keeping practices for home aquariums during the COVID-19 pandemic
Authors: Koochaknejad E. , Ghazilou A. , Kor K. , Ershadifar H.
Published: June 2022

Human–animal interactions can generate a variety of benefits for the psychological and physiological wellbeing of humans. Therefore, more people may prefer to keep pets (such as aquatic animals) during stressful events, like the COVID-19 pandemic. In this study, an international survey of aquarium keepers was conducted to assess their attitudes toward home aquariums during the COVID-19 pandemic. Over 80% of the respondents, irrespective of gender, age, employment status, number of owned aquariums, or aquarium maintenance experience, confirmed that aquariums have produced stress-relieving benefits during the COVID-19 pandemic. Approximately, one-quarter of home aquarium owners claimed to have bought more than 15 fish and 15 aquatic invertebrates since the beginning of the stay-at-home restrictions. The majority of the respondents confirmed that their aquarium(s) was/were properly maintained during these regulations, particularly compared to the years prior to the COVID-19 pandemic. To some extent, a shortage of supply of live foods affected the maintenance performance of home aquariums.
A survey on anesthetic procedures for elective surgeries in small animal practices in Flanders
Authors: Roggeman T. , Bosmans T. , Breynaert A. , Polis I.
Published: June 2022

To the authors’ knowledge, this is the first study to report and evaluate the auxiliary anesthetic equipment and procedures used for elective surgical castration procedures with a low perianesthetic risk in small animal practices in Flanders. This online survey showed an overall acceptable standard of anesthetic procedures by veterinarians in Flanders. Practices are fairly well equipped to monitor patients safely during anesthesia. The main areas of improvement include in general an absence of emergency crash kits and a lack of intraoperative fluid therapy. Specifically for feline anesthesia, there appears to be a lack of endotracheal intubation, IV access and anesthetic monitoring. Although postoperative analgesia is offered to most patients, additional attention should be given to provide analgesia for a sufficient period of time.
Online learning vs blended learning in developing students' self-regulation at Umm Al-Qura University
Authors:   Deanship of Common First Year, Umm Al-Qura University, Mecca, Saudi Arabia, Alharthi Ahmed D. , Elsigini Waleed T. ,   Deanship of E-Learning and Distance Education, Umm Al-Qura University, Mecca, Saudi Arabia,   Faculty of Education, Mansoura University, El-Mansoura, Egypt
Published: June 2022

The purpose of this research is to examine the impact of online learning and blended learning on developing students' self-regulation at Umm Al-Qura University, using gender and specialization variables. The research sample consisted of 376 students at Umm Al-Qura University in the academic year 2021–2022. According to the instructional type, the research sample was divided into the following main branches: Blended learning: 233 students dealt with blended courses, and online learning: 143 students dealt with online courses. A self-regulation questionnaire was developed to collect the required data from the study sample. The validity and reliability of the questionnaire were ensured. The findings of the study revealed that blended learning is more effective in developing students' self-regulation than online learning. Blended learning is more effective in developing male students' self-regulation compared to online learning. The effectiveness of blended and online learning on female students' self-regulation is equal. Blended learning is more effective in developing practical major students' self-regulation compared with online learning. It was observed that the effect of blended and online learning on theoretical major students' self-regulation is equal. The study findings enrich the understanding of the effect of both blended learning and online learning in developing learning outcomes. In addition, these findings may help decision-makers and stakeholders at higher education institutions to provide all available means for embedding blended courses in instructional systems.
THE CHARACTER OF LEPTIN PRODUCTION IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS
Authors: Budreiko O. A.
Published: June 2022

Determination of leptinemia in 106 children and adolescents with type 1 diabetes mellitus at the age of 6 to 18 demonstrated an increased leptin level durimg puberty (0,7 to 20,4 ng/ml) which corresponds to its physiological dynamics. The level of leptinemia in girls was on the whole higher and increased significantly at excessive body weight as opposed to boys. In the boys there was registered a prinsipal correlation of hyperleptinemia with atherogenic type of changes in the blood lipide spectrum, as well as a tendency to hypoleptinemia together with deterioration of carbohydrate metabolism compensation.
CYTOKINE PROFILE IN TEENAGE BOYS WITH DELAYED PUBERTYS
Authors: Turchina S. I. , Plekhova O. I. , Shlyakhova N. V.
Published: June 2022

The study of cytokine profile in teenage boys from 14 to 17 years with delayed puberty madeit possible to establish an increased interlekin1β concentration together with simultaneous decreasein TNF α concentration. Interlekin 1β and TNF α combined impact on the FSH production wasestablished. There were revealed correlations between the levels of sexual and gonadotropic hormonesand cytokines which suggested cytokines participation in the pituitary-gonadal system functioning.
CHANGES OF THE STATE OF IMMUNITY AND HORMONAL SYSTEMS OF REGULATORY FOR THE SPORTSMEN OF HIGH CLASS ON DIFFERENT PERIODS TO THE TRAINING-COMPETITION ACTIVITY
Authors: Korzh V. P.
Published: June 2022

The results of investigations represented at the article prove that the organism of an athlete reacts to physical overloads and due to this fact there is essentials increase of cortizol and serotonin levels. These changes are accompanied the expressed changes of immune status of organism of sportsmen. A change of parameters of immunity and hormonal systems of regulatory is the informing diagnostic criterion of the functional state of organism of sportsmen
ARTICLES OF HOMOCYSTEMI SPECIFICITIES IN AICLE ON TSUKROVI DIABETES 2 TYPE IN DOCTRINE VIEW INSULINEMIЇ TA ANDROGENIC BAKED (LOOKING LITERATURE TA VLASNI DANI)
Authors: Korpacheva-Zinich O. V. , Halangot M. D.
Published: June 2022

To date, it is clearly defined that type 2 diabetes mellitus (DM-2) is one of the leading risk factors for coronary heart disease (CHD) and myocardial infarction (MI). It was found that 80% of all deaths among people with diabetes are caused by cardiovascular diseases (CVD), and life expectancy depends on the time of their manifestation. If we compare the mortality rate from CVD in the general population and among patients with diabetes mellitus-2, in the latter it is several times higher.
EFFICACY OF PANCRAGEN PEPTIDE IN ELDERLY PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Korkushko O. V. , Shatilo V. B. , Havinson W. H. , Antonyuk-Shcheglova I. A.
Published: June 2022

The paper shows that in elderly patients with uncompensated diabetes 2 types of course application of the drug Pankragen (RF Patent № 2242241) on
Against the background of constant doses of glibenclamide leads to a significant decrease in plasma glucose levels on an empty stomach and 2 hours after the oral glucose tolerance test. An additional sugar -free effect is preserved two weeks after the cancellation of the pankration in 60 % of patients who continued to takeglibenclamide in previous doses. Pankochen has an additional sugar -free effect in patients with high initial resistance to insulinAnd hyperinSulinemia. Under the influence of the peptide preparation, the index decreases Homa insulin resistance. Any side effects or undesirable changes in laboratory indicators associated with the receptionObserving. Pankochen is shown to an elderly patient with an uncompensated course of type 2 diabetes with insufficient effectiveness of therapeuticGlibenclamide dosages.
INFLUENCE OF OOCYTIC MICROWAYS ON THE RESULT EXTRACORPORAL FERTILIZATION FOR HYPERANDROGENIA
Authors: Somova O. V. , Feskov O. M. , Feskova I. A.
Published: June 2022

In 64 women with different androgenic status who were treated for infertilityin vitro fertilization methods, in the follicular fluid surrounding the oocytes, the levels of sex hormones, leptin, sex hormone-binding globulin, total antioxidant and total oxidative activity are determined. For excess androgens

An oxidative / antioxidant balance was observed in the follicular fluid in the direction of an increase in the total oxidative activity. In women with a day off

hyperandrogenism, the content of sex hormone-binding globulin and leptin in the oocyte microenvironment is essential for obtaining high-quality embryos and

achieving pregnancy in in vitro fertilization cycles.
ASSESSMENT OF THE PLATELET COMPONENT OF HEMOSTASIS IN RATS WITH METABOLIC SYNDROME AGAINST ESTROGEN DEFICIENCY
Authors: Gorbenko Nataliia , Oksenenko S. V. , Ivanova Olha , Borikov Oleksii , Stepanova A. V. , Taran K. V. , Zvyagina T. S.
Published: June 2022

The platelet component of hemostasis in rats with metabolic syndrome induced by a high-fat diet under conditions of eu- and hypoestrogenism.

It was found that in females receiving a high-fat diet, there is an increase in the degree, and in ovariectomized rats kept on a standard

diet, the rate of ADP-induced platelet aggregation increases. The combined effect of diet and estrogen deficiency causes a more pronounced increase

of both studied indicators, which indicates the summation of their procoagulant effect.
FEATURES OF THYROID FUNCTIONING PREGNANT AND HER FET (literature review)
Authors: Kravchun N. O. , Kazakov Alexandr , Romanova I. P. , Berdikov A. Ya. , Berdikov I. А
Published: June 2022

Histolohichne budova shchytovydnoyi zalozy ye typovym dlya zaloz vnutrishnʹoyi sekretsiyi - v niy vidsutni vyvidni protoky, a kozhna strukturna odynytsya (folikul) pov'yazana z krovonosnoyu systemoyu. Osnovna fiziolohichna rolʹ SHCHZ polyahaye v zabezpechenni orhanizmu tyreoyidnymy hormonamy - tyroksynom (T4) i tryyodtyronin (T3), nevid'yemnym strukturnym komponentom yakykh ye yod.
POSSIBILITIES AND ADVANTAGES OF THE COMBINED SAW LOWERING THERAPY
Authors: Kravchun N. A.
Published: June 2022

Today, type 2 diabetes is one of the leading causes of morbidity, disability and premature mortality worldwide. The incidence of type 2 diabetes has increased significantly over the past few decades. According to the WHO, type 2 diabetes is recognized as a non-infectious epidemic, in connection with which in 2006 the UN resolution on combating the disease was adopted.
THE ROLE OF SINGLE NUCLEOTIDE POLYMORPHISM +45T/G OF ADIPONEKTIN GENE (ADIPOQ) IN RISK OF TYPE II DIABETES MELLITUS DEVELOPMENT
Authors: Karachentsev Yuri , Gorshunska Maryana , Atramentova L. O. , Kravchun N. A. , Khizhnyak Oksana , Tyzhnenko T. V. , Grinchenko T. S. , Gladkih A. I. , Leshchenko Zhanna , Shevchenko Y. A. , Pochernyaev A. K. , Romanova I. P. , Poltorak V. V.
Published: June 2022

Single nucleotide polymorphism (SNP) +45T/G gene of adiponectin (ADIPOQ) in type 2 diabetes mellitus patients and in healthy residents of Kharkiv has been taken into consideration. Frequencies of SNP +45T/G for patients (pG = 0,48; pT = 0,52) and healthy residents(pG = 0,49; pT = 0,51) do not differ significantly. The genotypes frequency in control group doesn’t correspond to HardyWeinberg equilibrium: the share of heterozygotes +45T/G is 1,8 times higher than selectively-neutral value. The type II diabetes mellitus patients have the share of heterozygotes +45T/G one third lower than in control group. The analysis has shown that heterozygotes genotype reduces the risk of type 2diabetes mellitus in seven times (p < 0,05) in comparison with a mean value in population.
THE CLINICAL AND HORMONAL CHARACTERISTICS OF PATHOLOGICAL PUBERTY IN RURAL RESIDENTS
Authors: Varodova O. V.
Published: June 2022

For determining clinical and hormonal characteristics of sexual development disorders in boysfrom rural locality there were examined 62 adolescents aged 14–18 with clinical signs of sexual developmentdelay (SDD). The examination has shown that in one half of adolescents (51,6 %) sexualdevelopment is observed till the age of 3, in 43,8 % of patients sexual development degree is 3–4 years behind and only 4,7 % of youths (mainly at the age of 17–18) sexual development degree is 4 and even more years behind. The majority of adolescents with SDD (85,9 %) are likely to have deviations in their physical development with undersized stature as a prevailing feature. The pathological proportions of body have been revealed in all adolescents. Hormonal indexes of boys with SDD are characterized by a decreased level of one or both gonadotropins, an increased level of prolactin, a low testosterone level as well as disorders in T/ E2 correlation and by sensitivity of gonads to LH impact at the age of 14–15.
THE STATE OF COMPENSATION OF CARBOHYDRATE EXCHANGE AND HAEMODYNAMICS RATES OF THE LOWER EXTREMITIES IN CHILDREN OF DIFFERENT AGE WITH I TYPE DIABETES MELLITUS ON INPATIENT STAGE OF REHABILITATION TREATMENT
Authors: Kirilyuk M. L. , Volyanska V. S. , Govorova N. V.
Published: June 2022

The article is dedicated to the study of the state of carbohydrate exchange compensation and haemodynamics rates of lower extremities in children of two age groups (6–13 and 14–17 years old) with type I diabetes mellitus after the inpatient treatment. It is found out that 14–17 years old children have a higher risk of getting complications of this disease according to the indicators of glycated hemoglobin. Complex treatment with the usage of magnitolazerotherapy, magnetic therapy and vortical baths directed to the lower extremities can improve the state of their haemodynamics in children of both age groups, especially in junior group.
THE INFLUENCE OF TETRAPEPTIDE PANCRAGENE® ON THE EXPERIMENTAL DIABETES MELLITUS DEVELOPMENT
Authors: Havinson V. H. , Malinin V. V.
Published: June 2022

The analysis of amino acid sequences of insulinotropic polypeptides has revealed a common shortsegment, consisting of four amino acid residues. Tetrapeptide KEDWa analogous to this segment and protected from the effect of amino acid proteinases has been synthesized. The intramuscular administration of this tetrapeptide to rats with alloxan diabetes has promoted the insulin synthesis being partially restored. Under the condition of oral administration to rats with streptosotocin diabetes the tetrapeptide has exerted a pronounced hypoglycaemic effect within its administration. Intramuscular administration normalizes the adhesive ability of mesentery microvessels endothelium at the same time not affecting their permeability. The results point out a hypoglycaemic and endothelioprotective effect of the tetrapeptide in case of experimental diabetes mellitus.
THE DYNAMICS OF DAILY RHYTHMS OF THYROID GLAND HORMONAL ACTIVITY AT HYPOPINEALISM, INDUCED BY THE LONG-TERM AROUND-THECLOCK ILLUMINATION
Authors: Bondarenko L. O. , Sotnyk N. M.
Published: June 2022

In sexually matured male rabbits kept in the conditions of around-the-clock illumination the daily dynamics of thyroxine concentration in the blood has been observed. The above-mentioned rhythm is not indicated in the case of triiodthyronine. In rabbits affected by hypopinealism and induced by a long-term around-the-clock illumination phase changes of thyroid gland hormonal activity are observed. These changes connected with the gradual decline of thyroid gland hormonal activity show up synchronously in the day time and at night.
THE PROTECTIVE IMPACT OF ESTRADIOL DERIVATIVE PE0607 ON METABOLIC MANIFISTATIONS DEVELOPMENT OF INSULIN RESISTANCE SYNDROME IN OVARIECTOMIZED RATS FED ON HIGH-FRUCTOSE DIET
Authors: Taran K. V. , Gorbenko Nataliia , Ivanova Olha , Yaremenko Fedir
Published: June 2022

The effect of compound PE0607 on the development of metabolic syndrome induced by chronic supplementation with high fructose diet was investigated in rats with estrogen deficiency. It was established that PE0607 administrations improves glucose intolerance, insulin sensitivity, decreases body and visceral fat weights, content of cholesterol, normalizes the concentration of triglycerides and increases production of the nitric oxide. In addition, uterine weight was not affected by compound PE0607 that may decrease the risks of adverse health effects. These results justify the perspectives of compound PE0607 use as the potential agent for the treatment of metabolic disturbances in postmenopausal women.
EXPRESSION OF FREE CORTISOL IN THE URINE OF NEWBORN IN THE FIRST DAYS OF LIFE
Authors: Riga O. O.
Published: June 2022

In a cohort of 80 newborns with different body weight at birth, content was studied of free cortisol in the urine. Analysis of the results of the study in different units of measurement showed significant difference between the indicators in children of different weight categories, as well as the dependence on the daily diuresis and features of the course of the early neonatal period. For the interpretation of indicators free cortisol in the urine of newborn babies should be brought to their body weight and urine volume per day.
Crises as impulses for changes in socio-economic systems
Authors: Mączyńska Elżbieta
Published: June 2022

The analyses presented in this essay are aimed at identifying potential directions of rationalization of socio-economic systems, designed not only for counteracting crisis destructions, but most of all the current global crisisogenicity. The need to search for rationalising solutions is not only demonstrated by the crisis that is encompassing the world in connection with the COVID-19 pandemic and which exposes the systemic dysfunctions of the global economy. This is also confirmed by the crisis multiplication characteristic of the modern world and already occurring before the pandemic, i.e. the overlapping of various crises, which creates a specific thickening crisis network. This intensifies discussions and questions concerning possible future directions of change in socio-economic systems. These questions are even more important because of the persisting neoliberal so-called zombi-ideas, i.e. ideas which, despite the fact that reality absolutely does not confirm their validity, are artificially and in the interest of narrow social groups kept alive and constitute a barrier to restoring order in the local and global dimension. In this context, this essay analyzes concepts that differ from the neoliberal ones, including the concept of Doughnut economics by British economist Kate Raworth. This economist demonstrates that the more economic growth is not in harmony with social and ecological progress, the larger the hole inside the doughnut is. The centre hole of the model is a metaphor for social destruction and neglect. However, the field of the doughnut itself is a metaphor for a safe and just socio-economic model, eliminating poverty on the one hand and planet-destroying consumerist excess on the other. The inner bottom edge of the doughnut illustrates the goals of social justice and welfare, which should be expanded reducing aforesaid hole. The outer edge determines the impassable limits of the burdens on the natural environment. The relationship between this concept and the ordoliberal model of the social market economy is analyzed. By definition, it is a model of political system focused on socio-economic order, a model with a treaty and constitutional status in the European Union countries. Ordo means order. However, the formal enshrinement of this model does not fully translate into socio-economic reality. Therefore, this model needs to be strengthened and adapted to the requirements of the fourth industrial revolution encompassing the world nowadays. The analyses presented in this essay indicate that this reinforcement could be achieved through combining the intellectual potential of the SOME model and the Doughnut economic model. Both of these concepts have in common their pro-social orientation, harmonizing economic, social and environmental objectives, balancing the socio-economic system, which prevents the occurrence of asymmetries that are harmful to socio-economic development.
Territorial self-government and “LGBT-free zones”
Authors: Wieczorek Anna
Published: June 2022

Several dozen of self-governments – municipal and county councils and regional assemblies passed resolutions and declarations against the LGBT ideology. The authors of these documents emphasized the will to protect the family based on traditional values and to defend the education system against LGBT propaganda/ideology. Opponents warned against the stigmatization of non-heteronormative people. The guideline for the above-mentioned documents became the “Local Government Charter of Family Rights”, published in 2019. Signs “LGBT-free zone” have appeared at the entrances to areas administered by self-governments that have adopted such declarations or resolutions. The dispute has become increasingly wide-ranging and has involved the media, the courts, the prosecutor’s office, the Ombudsman, the European Parliament, and the European Commission. The author of this article does not take sides. He merely believes that unnecessary quarrels harms our country. To demonstrate the absurdness of the argument over “LGBT-free zones”, the article refers to: – the selected documents relating to local government (declarations, resolutions, court judgments) and the “Local Government Charter of Family Rights” – generally binding acts of law relating to the self-government, family and educational tasks; – biographies of people (e.g. writers) who should be considered positive in Polish and World history, despite their complicated family life. The selection of the analyzed data can be considered subjective. The author chose the documents of local governments of Małopolska and Beskid Mountains, because he considers the areas managed by them to be very attractive for tourists – he likes to spend holidays in Cracow, Zakopane and Beskid Śląski and Żywiecki, e.g. in Koniaków and Żywiec. The reading list for secondary schools, adopted by the Minister of National Education, determined the selection of writers’ biographies. The choice of the others was determined by the uniqueness of their biographies and the impact on the history of Poland and the world. Finishing work on the article in March 2022, the author consciously introduced the theme of Ukraine.
Optimization of radiotherapy combined course for rectal cancer
Authors:   National Research Tomsk Polytechnic University, Grigorieva A.A. , Bulavskaya A.A. ,   National Research Tomsk Polytechnic University, Nguyen Tuan Anh ,   National Research Tomsk Polytechnic University, Stuchebrov S.G. ,   National Research Tomsk Polytechnic University, Startseva Zh.A. ,   Cancer Research Institute of Tomsk National Research Medical Centre of the RAS, Velikaya V.V. ,   Cancer Research Institute of Tomsk National Research Medical Centre of the RAS, Turgunova N.D. ,   Cancer Research Institute of Tomsk National Research Medical Centre of the RAS, Miloichikova I.A. ,   National Research Tomsk Polytechnic University,   Cancer Research Institute of Tomsk National Research Medical Centre of the RAS
Published: June 2022

Due to the new rapidly developed technological equipment for radiotherapy available in cancer clinics, the study of the optimal combination of topometric preparation of a patient with planning and the delivery of treatment in order to achieve the main goal of radiation therapy – maximum exposure of the foci with minimal damage to healthy tissue. The reduction of dose to critical or-gans and healthy tissues in general is an important and urgent task. The purpose of the paper is to explore the possibility of optimization of the combined radiation therapy in patients with rectal cancer, with account of advanced approaches to topometric preparation of a patient and dosime-try planning. Six patients 47-59 years of age, with the stage III of the lower ampullary rectal can-cer, received two-phase pre-operative combined radiotherapy at the Tomsk Cancer Research In-stitute NMRC. The Phase 1 – distant radiation therapy delivery in standard mode with a single fo-cal dose (ROD) of 2 Gy, 5 times a week, totally 20 fractions, to focal dose (SOD) of 40 Gy. The Phase 2 – intracavitary radiation therapy, ROD – 3 Gy, SOD – 15 Gy, locally in the tumor area, 2 times a week, total number – 5 fractions. The conventional radiation therapy planning was carried out with the use of the XiO 3-D dosimetry planning system for the "Theratron Equinox 80" (radia-tion of the isotope Co-60, Egamma=1.25 MeV), gamma-therapeutic apparatus, and for the SL75-5-MT (Electron braking radiation, E=6 MeV) linear accelerator. For conformal radial therapy the plan-ning system for linear accelerator «Elekta Synergy» (electron brake radiation, E=6 MeV) is used. For intracavitary radiotherapy the dosimetry planning system HDRPlus for the apparatus "Multi-Source" (radiation of isotope Co-60, Egamma=1.25 MeV) is used. Radiation doses to critical organs of pa-tients with lower ampullary rectal cancer exposed to combined course of radiotherapy was calculated. It has been shown that the use of advanced techniques for pretreatment topometric preparation of a patient and dosimetry planning makes possible optimization of combined radiotherapy with account of radiation doses to critical organs.
Development of fluorescence diagnosis and photodynamic therapy in A. Tsyb Medical Radiological Research Centre
Authors:   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Popovkina O.E. , Kapinus V.N. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Yaroslavtseva-Isaeva E.V. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Spichenkova I.S. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Borgul O.V. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Romanko Yu.S. ,   I.M. Sechenov First Moscow State Medical University, Ivanov S.A. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC),   Peoples’ Friendship University of Russia, Kaprin A.D. ,   National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (NMRRC)
Published: June 2022

Clinical application of photodynamic therapy (PDT) and fluorescence diagnosis is being extend-ed in Russia. A. Tsyb MRRC scientists headed by Professor M. Kaplan have conducted experi-mental studies of the photosensitizers (PS): Photochem, Photosens, Photolon, Photoditazin, Radachlorin, Photoran, belonged to different classes, estimated their therapeutic effectiveness for malignant tumors of different histologic type. From the study of basic mechanisms of photo-chemical reactions with chlorine photosensitizers it became evident that the photosensitizers de-stroyed microciculatory bed, inhibited proliferation and tumor cells functional activity, induced apoptosis and necrosis at early stages of a tumor development. Effects of PS dosage and dose of light to be delivered to a target on a treatment outcome were studied. The results of experi-mental studies were used to support clinical application of focal, interstitial, systemic techniques with different PS as individual treatment modalities or as a modality combined with radiation therapy, surgery, chemotherapy, electrochemical lysis. Optimal PS and light exposure doses were determined, indications for the use of optimal PS and light doses for treatment of malignant neoplasms of the skin and the mucous membranes were formulated. Due to the use of high-tech effective treatment modalities developed in the Department of Fluorescence Diagnosis and Pho-todynamic Therapy of A. Tsyb Medical Radiological Research Centre – the branch of the Medical Research Radiological Centre thousands of patients have been cured.