bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic drug monitoring of adalimumab in inflammatory bowel disease in children
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Illarionov A.S. , Radygina T.V. ,   National Medical Research Center for Children’s Health, Moscow, Russian Federation, Potapov A.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   National Medical Research Center for Children’s Health, Moscow, Russian Federation, Fisenko A.P. ,   National Medical Research Center for Children’s Health, Moscow, Russian Federation, Kuptsova D.G. ,   National Medical Research Center for Children’s Health, Moscow, Russian Federation, Petrichuk S.V. ,   National Medical Research Center for Children’s Health, Moscow, Russian Federation, Surkov A.N. ,   National Medical Research Center for Children’s Health, Moscow, Russian Federation, Vershinina M.G. ,   National Medical Research Center for Children’s Health, Moscow, Russian Federation
Published: September 2021

Objective. To evaluate the significance of therapeutic drug monitoring of adalimumab (ADA) concentration levels and antibodies to it in inflammatory bowel disease (IBD) in children. Patients and methods. In this study, 103 children with IBD (24 patients with ulcerative colitis (UC) and 79 with Crohn’s disease (CD)) aged 3–18 years were examined during maintenance therapy with ADA (100 mg/mL in 0.4 mL). Body weight, duration of disease and therapy, use of azathioprine (AZA), achievement of clinical and endoscopic remission, albumin levels, residual levels of ADA and antibodies to the drug, circulating cytokine levels in serum were assessed. Results. A significant decrease in ADA levels in children in the absence of clinical remission in CD (5.21 [3.32; 7.43] μg/mL in remission) and in UC (2.42 [0.42; 4.51] μg/mL, p = 0.001) was shown. A high-quality separation model for residual ADA levels for exacerbation/remission conditions for clinical and endoscopic activity for children with CD and UC was obtained through ROC-analysis. The minimum residual ADA levels for maintaining clinical remission in children with CD were 8.1 μg/mL and 10.5 μg/mL for mucosal healing. In children with UC, as well as in children weighing <40 kg, these levels were higher. The formation of antibodies to ADA was minimal; combination therapy with AZA showed no efficacy. Key cytokines correlating with ADA concentration were interleukins IL-6, -13, -31, -27, -9, and tumor necrosis factor-α. Conclusion. To improve the efficacy of ADA therapy in children with IBD, therapeutic drug monitoring should be performed, considering the nosology and body weight of the child, as well as the goal of therapy (clinical and endoscopic remission). Key words: inflammatory bowel disease, Crohn’s disease, ulcerative colitis, adalimumab, therapeutic drug monitoring, tumor necrosis factor-α, cytokine profile, azathioprine
Features of very early-onset inflammatory bowel disease: the experience of the Federal Pediatric Center
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Shumilov P.V. , Shchigoleva A.E. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: September 2021

Objective. To clarify the incidence of monogenic IBD-like diseases and the features of clinical course and response to therapy of major types of inflammatory bowel diseases (IBD) among children under the age of 6 with manifestation of the disease. Patients and methods. The study included 135 children under the age of 6 with manifestation of IBD; in the comparison group, there were 128 children after the age of 6 with manifestation of IBD (97 children with ulcerative colitis (UC) and 31 children with Crohn’s disease (CD)) who were observed for at least 1 year. All children underwent a standard examination, including calprotectin and antineutrophil antibodies testing, determination of activity by the Pediatric Ulcerative Colitis Activity Index (PUCAI) or the Pediatric Crohn’s Disease Activity Index (PCDAI), depending on the nosology. Children with the onset of IBD under 6 years of age underwent a genetic testing using Primary Immunodeficiency Panel by next-generation sequencing. All children were analyzed for efficacy of therapy during catamnestic observation. Results. It was revealed that in the study group the incidence of monogenic IBD-like diseases was 6.7%, of UC – 71.1%, of CD – 22.2%. Major types of IBD with very early onset differed little in their clinical, endoscopic and laboratory features from the forms with manifestation at an older age. In most cases, both CD (57%) and UC (71%) were characterized by low activity. Very earlyonset CD was characterized by isolated localization of the colon (53%, p = 0.037) and a non-stenotic and non-penetrating behaviour of the disease (60% of cases). The leading clinical symptoms were diarrhea (67%) and blood in the stool (63%, p = 0.04). Very early-onset UC was characterized by total lesion of the colon (84%, p = 0.001) and the development of anemia (48%, p = 0.01). Among children with very early-onset UC, the percentage of glucocorticosteroid-dependence and glucocorticosteroid-resistance was high, but anti-TNFα therapy was prescribed late. Conclusion. It is advisable to observe children with very early-onset IBD in federal multidisciplinary clinics, where there is experience in managing patients with this pathology. Key words: inflammatory bowel disease, very early onset, Crohn’s disease, ulcerative colitis, primary immunodeficiency, treatment, children
Impact of cleft palate repair on speech and development of dentoalveolar deformities
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Stebeleva Yu.V. , Mamedov Ad.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Volkov Yu.O. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, McLennan A.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Dudnik O.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Guo Hao Guo Hao ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ma Gupei Ma Gupei ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Goncharova O.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: September 2021

Surgical repair of cleft palate is quite difficult because it aims not only to eliminate the anatomical defect of the palate, but also to ensure normal functioning, including speech. Moreover, successful surgery implies no or minimal deformation of the middle face that can be corrected in the late postoperative period. No doubt that primary surgery (both in terms of technique and time) is crucial for further growth and development of the maxilla. However, surgical techniques and the age of primary cleft palate repair vary between different clinics, which makes this literature review highly relevant. Key words: cleft palate repair, cleft palate, congenital cleft lip and palate
Clinical manifestations of Williams syndrome in children
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Vitebskaya A.V. , Frolkova N.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shakhnazarova M.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: September 2021

Williams syndrome (WS), also known as Williams–Beuren syndrome, is a rare genetic disorder affecting many organs and caused by hemizygous deletions of the long arm of chromosome 7 (7q11. 23). In this article, we describe typical pathological changes in the cardiovascular, endocrine, urinary, digestive, and nervous systems, as well as phenotypic characteristics and psychological aspects of this disease. We also cover a correlation between clinical manifestations of WS and genes in the remote area. The article contains a summary of the main recommendations for the treatment of individual manifestations, i.e. pathological conditions associated with this syndrome. Key words: children, Williams syndrome, cardiovascular disorder, hypercalcemia, hypothyroidism, growth retardation, mental retardation
Vaccination of children with autoimmune rheumatic diseases. Current state of the problem
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, M.K.Osminina M.K.Osminina , I.A.Dronov I.A.Dronov ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, S.S.Telkova S.S.Telkova ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, A.V.Skvortsov A.V.Skvortsov ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, N.S.Podchernyaeva N.S.Podchernyaeva ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: September 2021

Vaccination of children with autoimmune rheumatic diseases is a significant problem since infectious diseases remain the main cause of complications of anti-rheumatic therapy and one of the leading causes of death in this category of patients. This review presents current information on the frequency of comorbid infections, the accumulated experience of vaccination in children with autoimmune rheumatic diseases. The recommendations of The European League Against Rheumatism (EULAR) for vaccination in paediatric patients with rheumatic diseases are presented in detail. The presence of rheumatic disease is not an exception for vaccination, it is recommended for all children following national guidelines. Non-live vaccines are effective and safe in paediatric patients with rheumatic diseases. Live vaccines are not recommended for patients receiving high doses of glucocorticoids, immunosuppressive and biologics therapy due to the risk of infectious complications. Vaccination against pneumococcal infection and seasonal influenzais are hihgly recommended. Key words: vaccination, children, autoimmune rheumatic diseases, guidelines, review
Effect of Firm Size Firm Growth Firm Age and Independent Commissioner on Intellectual Capital Disclosure in Banking Companies Listed on the Indonesia Stock Exchange in the period 2014 – 2018
Authors: Khosi'ah Lailatul , Sriyono
Published: September 2021

The purpose of the study was to determine and analyze the effect of Firm Size, Firm Growth, Firm Age and Independent Commissioner on Intellectual Capital Disclousure partially and simultaneously to determine a model that can be used to measure Intellectual Capital Disclousure in companies by using panel data regression in Registered Banking companies on the Indonesia Stock Exchange. This study applies quantitative method and the object of this research is done by population and sample randomly (purposive sampling), which are 11 consumer goods companies that were Listed on the Indonesia Stock Exchange in the period 2014 - 2018. The technique of collecting data used annual financial statements from the period 2014 - 2018 and analysis used panel data regression method with common model approach using Eviews 9 program.The results of this study showed that simultaneously and partially variables Firm Size, Firm Growth, Firm Age and Independent Commissioner have a significant effect on Intellectual Capital Disclousure
Integrated Science Education Mobile Application: Edukit for 21st Century Skills
Authors: Yulianti Erni , Maharani Desta Wahyu , Hamimi Erti
Published: September 2021

Problem solving skills are one of 21st Century Skills. However, based on the results of studies and interviews students still lack in problem solving skill because most of them only study from textbooks at school.  The purpose of this research is to produce science education media equipped with experimental manuals and context in the application that students can use anytime and anywhere either independently or by teacher guidance. This development research adopts the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). The results of expert validation and legibility test show that the education KIT integrated mobile application is very suitable. Media expert validation obtained a score of 98% and material expert obtained a score of 99%. In addition to the validation results, a readability test was also carried out by the teacher and students with the respective scores of 96% and 91%. Based on the validation and readability test Edukit IPA is integrated with a mobile application as a practical, complete, and capable medium for practicing the results of student problem solving skill, because each stage of the experimental activity is based on indicators of problem solving skills.
Reconstruction of E-Module of Circular Motion Based Guided Inquiry
Authors: Prihatiningtyas Suci , Alimah Siti
Published: September 2021

This study aims to determine the feasibility of the E-Module Circular Motion Based Guided Inquiry. This research is a research development or Research and Development (R&D) with the ADDIE model. The research instrument used was a validation sheet by the validator and student response questionnaires. The results of the validation sheet and student response questionnaires were assessed based on the Likert scale. The results of data analysis from the validation results of the E-Module Circular Motion Based on Guided Inquiry obtained a percentage of 92,02%. This shows that in general the E-Module Circular Motion Based on Guided Inquiry that was developed is very feasible to be used in learning circular motion material in class X SMK. E-Module Circular Motion Based on Guided Inquiry is a medium that can attract the attention of students.
Disadvantage or Blessing in Disguise? Field Research in Japan during COVID-19
Authors:   Jawaharlal Nehru University, Arora Swati
Published: September 2021

Area studies is an interpretive research field, and fieldwork is a key enabler for area studies research projects. However, field research also results in some fundamental challenges, which are described in varied literature available for scholars of anthropology, geography, social sciences and various other fields. Within area studies literature, there is little which deals with how to manage fieldwork without being present on the field. This paper reflects upon my experience of being on fieldwork in Japan during the global COVID-19 pandemic. It shares my experiences during 2020 and early 2021 and discusses how COVID-19 affected various aspects of fieldwork in Japan, including unexpected challenges, new opportunities, institutional support and accessing academic texts. The paper aims to give a concrete picture of fieldwork in Japan for other scholars who are yet to conduct research in the COVID-19 context. The paper maps out how the pandemic has affected the field, why it is so, and future implications while also decoding field research challenges and offering achievable solutions.
Emergency Management of Medical Wastewater in Hospitals Specializing in Infectious Diseases-a Case Study on Huoshenshan Hospital
Authors: He Jiajun , Zhao Shushu , Zhang Hui , Liu Xiaying , Li Qin , Fu Wenxuan , Sun Changhang
Published: September 2021

Background: Medical wastewater from hospitals specializing in infectious diseases is a major health and environmental risk during pandemics. However, few systematic studies on medical wastewater management in hospitals of infectious diseases have been reported. As designated emergency field hospital for the treatment of COVID-19, the Huoshenshan Hospital achieved successful outcomes on emergency management measures of medical wastewater.Results: The lessons of medical wastwater based on Huoshenshan Hospital can be concluded following four aspects: (1) Emergency management system of medical wastewater based on the “Internet Plus” technology, and other related management schemes and standard systems provided legislative foundation for emergency management of medical wastewater. (2) The three-tier prevention and control system of medical wastewater ensured the discharged wastewater meets water quality standards. The system specifically included the individual seep and leak-proof sealed collection system at the first tier, as well as the enhanced disinfection and moving bed bioﬁlm reactor wastewater biological and chemical treatment technology at the second tier. (3) The study established an effective three-tier accountability system in medical wastewater quality monitoring, data recording, storage, and reporting, as well as data review and filing, especially in continuous data monitoring and dynamic analysis of characteristic indicators. (4) Information disclosure by government and public supervision promoted successful implementation of medical wastewater management and control measures. Based on the results of 212 public questionnaires, we also confirmed that information of the case was open to public and internet users who actively participated. Conclusion: Our study will provide methodological reference for the emergency management of wastewater in designated infectious disease hospitals in similar situations.
Generalized Relational Tensors For Irregularly Sampled Time Series: Methods To Store, Re-generate, And Predict
Authors: Gromov Vasilii , Necheporenko Anastasia , Gaisin Andrei , Volkov Ilya , Diner Stanislav
Published: September 2021

The paper deals with a generalized relational tensor, a novel discrete structure to store information about a time series, and algorithms (1) to fill the structure, (2) to generate a time series from the structure, and (3) to predict a time series, for both regularly and irregularly sampled time series. The algorithms combine the concept of generalized z-vectors with ant colony optimization techniques. In order to estimate quality of the storing/re-generating procedure, a difference between characteristics of the initial and regenerated time series is used. The structure allows working with a multivariate time series, with an irregularly sampled time series, and with a number of series as well. For chaotic time series, a difference between characteristics of the initial time series (the highest Lyapunov exponent, the auto-correlation function) and those of the time series re-generated from a structure is used to assess the effectiveness of the algorithms in question. The approach has shown fairly good results for periodic and benchmark chaotic time series and satisfactory results for real-world chaotic data.
WITHDRAWN: Efficient Facial Emotion Recognition Model using Deep Convolutional Neural Network and Modified Joint Trilateral Filter
Authors: Kumari Naveen , Bhatia Rekha
Published: September 2021

Facial emotion recognition extracts the human emotions from the images and videos. As such, it requires an algorithm to understand and model the relationships between faces and facial expressions, and to recognize human emotions. Recently, deep learning models are extensively utilized enhance the facial emotion recognition rate. However, the deep learning models suffer from the overfitting issue. Moreover, deep learning models perform poorly for images which have poor visibility and noise. Therefore, in this paper, a novel deep learning based facial emotion recognition tool is proposed. Initially, a joint trilateral filter is applied to the obtained dataset to remove the noise. Thereafter, contrast-limited adaptive histogram equalization (CLAHE) is applied to the filtered images to improve the visibility of images. Finally, a deep convolutional neural network is trained. Nadam optimizer is also utilized to optimize the cost function of deep convolutional neural networks. Experiments are achieved by using the benchmark dataset and competitive human emotion recognition models. Comparative analysis demonstrates that the proposed facial emotion recognition model performs considerably better compared to the competitive models.
Molecular Indicators of Biomaterials Osteoinductivity - Cell Migration, BMP Production and Signalling Turns a Key
Authors: Łukowicz Krzysztof , Zagrajczuk Barbara , Wieczorek Jarosław , Millan-Ciesielska Katarzyna , Polkowska Izabela , Cholewa-Kowalska Katarzyna , Osyczka Anna M.
Published: September 2021

In this work we dissect the osteoinductive properties of selected bioactive materials obtained in a 3D form, and based on PLGA matrix and 2 types of gel-derived bioactive glasses (SBGs) of SiO2-CaO system, each with and without P2O5. The study is designed to avoid any osteogenic stimuli beyond the putative osteogenic bioactive glass compound of the studied materials. Previously we found that, when used as growth surfaces (i.e. material sheets), some of these materials were capable to support osteogenesis of bone marrow stromal cells (BMSC) without the need for any additional osteogenic cell treatment. In this work we explore further the role of BMP production and signaling upon BMSC culture on selected, SBG/PLGA 3D scaffolds as well as BMSC migration toward the condition media obtained from such cell-loaded materials. Our results show that BMP signaling of osteoprogenitor cells as well as their migration rate may present important indicators of materials osteoinductivity.
Sex-Specific Alterations in Inflammatory MicroRNAs in Mouse Brain and Bone Marrow CD11b+ Cells Following Traumatic Brain Injury
Authors: Prajapati Paresh , Wang Wang-Xia , Pesina Steven A. , Geleta Urim , Springer Joe E.
Published: September 2021

Sex is a key biological variable in traumatic brain injury (TBI) and plays a significant role in neuroinflammatory responses. However, the molecular mechanisms contributing to this sexually dimorphic neuroinflammatory response remain elusive. Here we describe a significant and previously unreported tissue enrichment and sex specific alteration of a set of inflammatory microRNAs (miRNAs) in CD11b + cells of brain and bone marrow isolated from naïve mice as well as mice subjected to TBI. Our data from naïve mice demonstrated that expression levels of miR-146a-5p and miR-150-5p were relatively higher in brain CD11b + cells, and that miR-155-5p and miR-223-3p were highly enriched in bone marrow CD11b + cells. Furthermore, while miR-150-5p and miR-155-5p levels were higher in male brain CD11b + cells, no significant sexual difference was observed for miR-146a-5p and miR-223-3p. However, TBI resulted in sex specific differential responses of these miRNAs in brain CD11b + cells. Specifically, miR-223 levels in brain CD11b + cells were markedly elevated in both sexes in response to TBI at 3 and 24 hr, with levels in females being significantly higher than males at 24 hr. We then focused on analyzing several miR-223-3p targets and inflammation-related marker genes following injury. Corresponding to the greater elevation of miR-223-3p in females, the miR-223-3p targets, TRAF6 and FBXW7 were significantly reduced in females compared to males. Interestingly, anti-inflammatory genes ARG1 and IL4 were higher in females after TBI than in males. These observations suggest miR-223-3p and other inflammatory responsive miRNAs may play a key role in sex-specific neuroinflammatory response following TBI.
Alexander invariants and cohomology jump loci in group extensions
Authors: Suciu Alexander I.
Published: September 2021

We study the integral, rational, and modular Alexander invariants, as well as the cohomology jump loci of groups arising as extensions with trivial algebraic monodromy. Our focus is on extensions of the form 1→K→G→Q→1, where Q is an abelian group acting trivially on H1(K;ℤ), with suitable modifications in the rational and mod-p settings. We find a tight relationship between the Alexander invariants, the characteristic varieties, and the resonance varieties of the groups K and G. This leads to an inequality between the respective Chen ranks, which becomes an equality in degrees greater than 1 for split extensions.
The Doctrine of Tawḥīd and its Practical Manifestation by a Living Sufi Practitioner
Authors: Aždajić Dejan
Published: September 2021

This article explores new pathways of understanding the theological doctrine of tawḥīd from a Sufi theological perspective. It is evident that Sufism has expanded the inherent meaning of tawḥīd from the relatively simple idea of the Oneness of God to the philosophically complex phenomenon that reality is best expressed through an absolute unity of all existence. Instead of engaging in a dialogue about this important doctrinal principle with only written texts, this article intends to combine both traditional sources but also the actual voice of one contemporary Sufi practitioner. This original approach aims to circumvent the tendency of a top-down approach to the study of religion, provide a grassroots perspective, and a concrete example of how a theoretical concept can be practically manifested in the life of ordinary believers. Such a contribution is important, for it adds to wider empirical studies of Sufism a localized example that underlines the importance of investigating religion not merely through written texts, but also by a nuanced exploration from the point of view of spiritual seekers themselves. Since Sufis ultimately embark on a spiritual journey and long to attain proximity to God, abstract theory must be met with experiential satisfaction.
Islamic Authority Figures and Their Religioscapes in Indonesia
Authors: Seise Claudia
Published: September 2021

In this article I argue that religious authority figures in Indonesia form the core of any given religioscape. A religioscape is a dynamic social space where one religious practice or religious interpretation is predominant. At the same time religious authority figures are influenced by the historically grown religioscape in which they live, and this mutual process affects all the people living in it. With the example of three religious authority figures and their respective learning institutions in Indonesia, I aim to illustrate how Muslim personalities influence and shape the religioscape that surrounds them. The first case study is grounded in the mystic Islam found in Yogyakarta, the second case study explores the mixture of local and Hadhrami influences in the Islamic practice of South Sumatra, while the third case study examines an imported form of reform Islam in a transmigrasi settlement. Of major importance in these case studies will be what influences the religious authority figures and what tools are used to disseminate their thoughts and interpretations of Islam. I argue that the concept of the religioscape enables us to better understand the impact that religious authority figures have on their surroundings and vice versa. It can also serve as a methodological tool to grasp the diverse plurality of Islamic practices in Indonesia.
Tuhfah al-Mursalah ila Ruh al-Nabiy as the Source of the Doctrine Seven Grades of Being in the Malay-Indonesian Archipelago
Authors: Badaruddin Faudzinaim
Published: September 2021

The doctrine of seven grades of Being (Martabat Tujuh) has been widely known to be a sufi interpretation of God’s Oneness (al-Tawhid). It originated in the subcontinent of India in the early seventeenth century. The doctrine was later introduced in Aceh and gained popularity among the Malay sufi authors and practitioners until the present day. Amid its wide acceptance, the teaching has long been considered by many scholars to be incompatible with the Islamic principle teachings of God’s Unity. The purpose of this article is to give an insight into the background of the writing of the Tuhfah al-Mursalah Ila Ruh al-Nabiyy and to establish its credibility as an authentic Islamic work by a recognized Muslim sufi scholar. To achieve its objectives, data of this writing was gathered through the usage of document analysis and then described using deducted and inducted analysis. This article found that the Tuhfah al-Mursalah was originally written to combatting misinterpretation of the teaching of wahdat al-wujud in the subcontinent India. It was later exported to the Aceh in the early sixteenth century. The work was written by a knowledgeable and important Indian Muslim sufi scholar. His credentials as a Muslim scholar were testified with few commentaries on the Tuhfah al-Mursalah by famous and well-known Muslim scholars in the Muslim world. Therefore, this work occupies an important place in providing a true comprehension of the doctrine of seven grades of Being.
Regulación de las encuestas electorales: Temas en debate
Authors: Abad Yupanqui Samuel B.
Published: September 2021

El presente artículo analiza la regulación vigente sobre las encuestas electorales, plantea los principales temas en debate y examina las propuestas de reforma presentadas. Resalta que la información que brindan las encuestas es fundamental en una democracia moderna, pues permite conocer la intención de voto de la ciudadanía en un momento determinado. Sus resultados no constituyen un pronóstico de lo que sucederá el día de la elección. Requisitos como la exigencia de un registro y de una ficha técnica resultan razonables. Sin embargo, la prohibición de difundir encuestas hasta el domingo anterior al día de la elección no se ajusta a la Constitución, por afectar derechos fundamentales, y tampoco a la realidad actual. Esta prohibición, introducida en el Perú hace 37 años, amerita ser revisada. Una medida razonable y proporcional debería autorizar la divulgación de encuestas hasta el día anterior a la elección.
Propuestas para una agenda en materia de derechos de propiedad rumbo al Bicentenario
Authors: Ravina Raúl
Published: September 2021

El presente trabajo tiene como finalidad transmitir la importancia de la regulación de los derechos de propiedad en el Perú en los diferentes tipos de actividades por parte de personas naturales y jurídicas para el desarrollo de sus proyectos. En ese sentido, el lector podrá apreciar las principales críticas y oportunidades de mejora respecto a la regulación actual en nuestro país para lo cual se intentará detallar de forma didáctica y breve el “diagnóstico” de las principales instituciones para garantizar el acceso a los predios y cuál debiera ser su correcta interpretación en beneficio de la sociedad en general.
Los convenios para evitar la doble imposición y su régimen constitucional de perfeccionamiento interno: ¿Una reforma esencial ante el Bicentenario de la República?
Authors: Salazar Urbina Daniel S.
Published: September 2021

El presente artículo analiza el problema de la exigua red de convenios para evitar la doble imposición que dispone el Perú en función del régimen constitucional para su perfeccionamiento interno, teniendo en cuenta el contexto actual demarcado por el Bicentenario de la República. La metodología empleada es cualitativa, producto de estudiar la situación desde un enfoque analítico y teórico.
Ante una pandemia, mejores reglas: las modificaciones en las reglas más importantes de arbitraje internacional a raíz de la pandemia por Covid-19
Authors: De la Flor Puccinelli Nicolás , Zagaceta Gómez Esther
Published: September 2021

En este artículo se describen los principales cambios suscitados en el arbitraje internacional a raíz de la pandemia originada por el Covid-19. De esta manera, ambos autores analizan tanto las Reglas IBA 2020 sobre Práctica de Prueba como el Reglamento Arbitral ICC de 2021. Entre ellos destacan las materias de audiencias virtuales, ciberseguridad, el deber de revelar la identidad del tercero financiador y la incorporación de partes adicionales a un arbitraje en curso.
Kilka uwag o medalach portretowych Zygmunta I Starego
Authors: Grzęda Mateusz
Published: September 2021

Na początku XVI w. medal portretowy był jedną z najoryginalniejszych form reprezentacji, która dzięki dużej ilości informacji na temat przedstawionej osoby, skumulowanej w niewielkim, trwałym, mobilnym i łatwym do powielenia przedmiocie, doskonale odpowiadała renesansowemu postulatowi sławy i nieśmiertelności. Możliwości, jakie oferował ten gatunek artystyczny, zostały zauważone w dworskim kręgu Zygmunta I Starego (1507–1548), co zaowocowało kilkoma seriami lanych i bitych w różnych metalach medali przedstawiających polskiego króla, powstałych na przestrzeni drugiego i trzeciego dziesięciolecia XVI w. W artykule rozwadze poddano proweniencję artystyczną tych medali, okoliczności ich powstania oraz rolę, jaką mogły one pełnić w praktyce władzy Zygmunta I.

Summary:

At the dawn of the sixteenth century portrait medals counted among the most orginal forms of representation which providing plenty of information on represented individual and accumulating it in a small, durable, mobile and easily reproducible object, met the Renaissance demand of fame and immortality. Advantages of this medium have been noticed in the courtly circle of king of Poland Sigismund I the Old (r. 1507–1548) thus leading to creation of several series of medals cast and strack in various metals in the second and third decade of the sixteenth century. The paper discusses authorship of these medals, as well as circumstances of their production and the role they could have played in the propaganda of Sigismund I’s power.
Polonorum Icones – zbiór „wyobrażeń ludzi w ojczyźnie znakomitych, na hołd potomności zasługujących”. Przyczynek do kształtowania kolekcji Gabinetu Rycin króla Stanisława Augusta
Authors: Przepałkowska Izabela
Published: September 2021

Zespół portretów sławnych Polaków Polonorum Icones powstał jako część kolekcji Gabinetu Rycin króla Stanisława Augusta. Wbrew dotychczasowym ustaleniom jego kształtowanie przypada na wcześniejsze lata niż rok 1778. W artykule podjęto próbę ukazania wpływu relacji między Poniatowskim a Michałem Mniszchem na formowanie się omawianego zespołu portretów oraz jego zależności od idei utworzenia Museaum Polonicum.

Summary:

The set of portraits of famous Poles, called Polonorum Icones, was a part of the Print Room of Stanisław August Poniatowski, the king of Poland. In spite of the opinion of previous researchers, this set of portraits was shaped earlier than 1778.

This article attempts to reveal the influence of the relation between King Poniatowski and Michał Mniszech on the formation of the discussed set of portraits. The author also raises the issue of the dependence of Polonorum Icones on the idea of creating Museaum Polonicum.
Sprawozdanie z konferencji "Metamorfozy koloru w sztuce". Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie, 9 grudnia 2020 r.
Authors: Tarnowska Magdalena
Published: September 2021

artykuł
Temperature Rise at the Pulp-Dentin Junction for a Multi-Layered Composite Restoration using the Finite Element Method
Authors: Ridha Ali Mohammed , Aidinis Konstantinos , Suliman Abdul Haq
Published: September 2021

Objectives:

During the light-curing process of composite restoration, excessive heat can be produced, which can potentially lead to pulp necrosis (death). In this study, we aimed, based on the Finite Element Method (FEM), to assess the risk of pulp damage during the light-curing process by investigating the influence of light-curing devices, under various irradiation regimes, on the temperature increase at the pulp-dentin junction, during a one-layer or multi-layered deep composite restoration.

Methods:

A Three-dimensional finite element method model of typical geometry and material properties, as commonly reported in the literature, was employed in COMSOL Multiphysics simulations in order to determine the temperature increase in the pulp. Various combinations of light intensities, durations, and irradiation regimes were investigated for the two cases, of shallow and deep multi-layered composite restoration.

Results:

Results of light-curing composite resins within enamel; indicate that the temperature rise during the curing process was within the safety margins. Results of light-curing composite resin restorations closer to the pulp with thin remaining dentin, indicate a temperature increase that could be sufficient to cause thermal injury in the pulp. Modulating the light output marginally, reduced the temperature rise while reducing the intensity and increasing the curing duration which was consistently more effective in this respect.

Conclusion:

The results clearly demonstrate that with currently adopted standard procedures, there exists a risk of thermal injury during multi-layered composite restorations with thin remaining dentin; it is thus important to establish appropriate curing regimes that would lead to minimal temperature increase during deep composite restorations and hence reduce the risk of thermal injury to the pulp.
RNN-based Fault Detection Method for MMC Photovoltaic Gridconnected System
Authors: Pang Yuqi , Ma Gang , Xu Xiaotian , Liu Xunyu , Zhang Xinyuan
Published: September 2021

Background:

Fast and reliable fault detection methods are the main technical challenges
faced by photovoltaic grid-connected systems through Modular Multilevel Converters (MMC) during
the development.

Objective:

Existing fault detection methods have many problems, such as the inability of non-linear
elements to form accurate analytical expressions, the difficulty of setting protection thresholds, and
the long detection time.

Method:

Aiming at the problems above, this paper proposes a rapid fault detection method for photovoltaic
grid-connected systems based on Recurrent Neural Network (RNN).

Results:

The phase-to-mode transformation is used to extract the fault feature quantity to get the
RNN input data. The hidden layer unit of the RNN is trained through a large amount of simulation
data, and the opening instruction is given to the DC circuit breaker.

Conclusion:

The simulation verification results show that the proposed fault detection method
has the advantage of faster detection speed without difficulties in setting and complicated calculation.
The role of thiol-disulfide and ischemia-modified albumin in the differential diagnosis of acute scrotum in children
Authors: Öztorun Can İhsan , Demir Rabia , Demirtaş Gökhan , Bostancı Süleyman Arif , Ertürk Ahmet , Karagöl Cüneyt , Şenat Almila , Erel Özcan , Güney Doğuş , Azılı Müjdem , Şenel Emrah
Published: September 2021

Aim: Testicular torsion which is the most common cause of acute scrotum, is a real surgical emergency. However, despite imaging techniques and laboratory studies used in the differential diagnosis of pathologies causing acute scrotum, the diagnosis is difficult. Therefore, there is a need for laboratory parameters that confirm the diagnosis of testicular torsion.In our study, we aimed to investigate the usability as a laboratory parameter in the differential diagnosis of acute scrotum causing inflammation in children via thiol-disulfide and ischemia-modified albumin(IMA) levels.
Methods: Of 60 children, 30 boys with acute scrotum and 30 healthy boys who were admitted for circumcision were included. The levels of native thiol(-SH), total thiol (SH + SS), dynamic disulfide(SS), dynamic disulfide(SS)/total thiol(SH + SS) % rate, albumin and IMA were measured. Patients’ pre-operative and postoperative first day blood samples’ laboratory findings were also compared.
Results: Native thiol(p = 0.025), total thiol(p = 0.032), dynamic disulfide(p = 0.045), albumin(p <0.001) and IMA(p <0.001) levels of the acute scrotum group were significantly higher than controls. IMA levels of epididymo-orchitis subgroup of acute scrotum were found higher than the testicular torsion subgroup. Pre and post-operative laboratory findings of the acute scrotum group were similar (for all variables p>.05).
Conclusion: The evaluation of thiol/disulfide homeostasis and IMA levels, and detection of changes in favor of oxidative stress might help in the differential diagnosis of the acute scrotum, but it cannot help to differentiate the testicular torsion from an epididymo-orchitis diagnosis.
SCARCITY MARKETING TO PERCEIVED UNIQUENESS AND DESIRABILITY USERS OF THE FOOD DELIVERY SERVICE INDONESIA APPLICATION
Authors:   Tourism Department, Universitas Ciputra Surabaya, Indonesia, Nafarin Lydia , Oktavio Adrie ,   Tourism Department, Universitas Ciputra Surabaya, Indonesia
Published: September 2021

The number of online applications users of food and beverage delivery services in Indonesia is growing every year. That is also followed by many culinary entrepreneurs who have established partnerships with online applications. One of the major online food and beverage delivery service applications in Indonesia is Grabfood. Through Grabfood, products ordered online by users will be delivered to their homes in a relatively short time. Ordering food and drinks through Grabfood is also very beneficial for users because they can enjoy a variety of attractive promotions, both in the form of food and beverage discounts, cashback, shipping cost discounts, and so on. One of the promotional strategies carried out by Grabfood is to do scarcity marketing. This study aims to observe whether the scarcity marketing carried out by Grabfood can affect the desirability of Grabfood users and at the same time examine the role of perceived uniqueness as an intervening variable in the model developed by this study. Scarcity marketing in the study is divided into two types, namely limited-quantity scarcity and limited-time scarcity. The sample in this study involved one hundred and thirteen active users of the Grabfood application who have filled out a complete online questionnaire. The data processing results show that limited-quantity scarcity and limited-time scarcity can directly have a positive and significant effect on perceived uniqueness and desirability. Furthermore, perceived uniqueness also has a direct positive and significant effect on desirability. In its position as an intervening variable, the construct of perceived uniqueness can partially mediate the relationship between limitedquantity scarcity and limited-time scarcity on desirability. Further research focused on another intervening variable that partially mediates the relationship between limited-quantity scarcity and limited-time scarcity to desirabilities, such as perceived value or social status.
THE EFFECT OF WORK FROM HOME ON EMPLOYEE PRODUCTIVITY IN BANKING INDUSTRY
Authors:   Master of Business Management, BINUS Business School, Indonesia, Prasetyaningtyas Sekar Wulan , Heryanto Clivensen ,   Master of Business Management, BINUS Business School, Indonesia, Nurfauzi Nadia Fasha ,   Master of Business Management, BINUS Business School, Indonesia, Tanjung Sugiharto Bangsawan ,   Master of Business Management, BINUS Business School, Indonesia
Published: September 2021

Recent COVID-19 Pandemic has forced many institutions to adopt work from home (WFH) practice whether they’re ready or not. Conditions affecting knowledge worker productivity while adopting new WFH practices become increasingly relevant as compa- nies adapt to the new normal era. This study investigates the direct impact of WFH on productivity and the mediating impact of WFH on productivity through work life balance (WLB) and job satisfaction in the banking industry located in the Greater Jakarta Area. As such, questionnaires were conducted with 234 respondents who have experience of the WFH program due to COVID-19 pandemic and working in the banking industry located in the Greater Jakarta Area. Findings revealed how job satisfaction is a mediating variable between WFH and Productivity, and WFH positively impacts overall productivity. However, contrary to our predictions, results also showed that WFH has a negative impact on WLB. Further research can extend the proposed model of this study by considering adding several variables which might affect productivity in WFH arrangements or implement the already proposed model to other industries.
THE EFFECT OF WORK FROM HOME ON CORPORATE CULTURE MEDIATED BY MOTIVATION, WORK BEHAVIOR, AND PERFORMANCE
Authors:   Institut Bisnis dan Informatika (IBI) Kosgoro 1957, Indonesia, Andriyanty Reny , Komalasari Farida ,   President University, Indonesia, Rambe Delila ,   Institut Bisnis dan Informatika (IBI) Kosgoro 1957, Indonesia
Published: September 2021

The research aims to analyze how WFH influences corporate culture through the availability of work facilities, motivation, work behavior, and employee performance. It is quantitative research using structural equation modeling. Data were obtained from 32 respondents that spread across Jakarta, Bekasi, and West Java. The results of this research show that WFH significantly affects the employee’s motivation. On the other hand, WFH has a significant direct effect on work motivation. Work motivation significantly affects work behavior. Work behavior affects employee performance significantly, and performance has a significant effect on innovative corporate culture. The analysis on the specific indirect effect resulted in significantly influencing innovation corporate culture from home through employee motivation, work behavior, and employee performance. Further research could explore the WFH-implementing mechanism as part of a culture of innovation for sustainable human resource development in the new-normal era of Indonesian companies
PHENOMENOLOGY STUDY OF CORPORATE ENVIRONMENTAL RESPONSIBILITY: A FORM OF CORPORATE SOCIAL RESPONSIBILITY BY PT AMERTA INDAH OTSUKA KEJAYAN
Authors:   Faculty of Economics and Business, Universitas Brawijaya, Indonesia, Budianto Risky , Triyuwono Iwan ,   Faculty of Economics and Business, Universitas Brawijaya, Indonesia, Mulawarman Aji Dedi ,   Faculty of Economics and Business, Universitas Brawijaya, Indonesia
Published: September 2021

This research is conducted to find deeper meaning regarding the implementation of CSR for the environment carried out by PT Amerta Indah Otsuka (Pocari Sweat) Kejayan. This research is non-positivistic research that leads to an interpretive paradigm with a transcendental phenomenological approach. This approach can explore the meaning of people who already have experience with CSR implementation of PT Amerta Indah Otsuka (AIO) Kejayan. The results show that this company’s CSR in the form of the environment are village greening, nursery rooms, making Biopore holes, conservation of water catchment areas, revitalizing the Bangil City square, revitalizing the Malabar City forest, and the cleanest hamlet and city forest competition. The realization of the CSR program is carried out based on existing needs and problems so that the company can open-heartedly assist in the form of social responsibility. Suggestions for future researchers are to make a phenomenological study to the public who get and feel the CSR program from the company so that readers can know the benefits and objectives of implementing CSR.
THE INTENTION TO USE E-COMMERCE TO PURCHASE GREEN COSMETICS WITH A MODIFIED UTAUT2 APPROACH
Authors:   Faculty of Economics and Business Universitas Brawijaya, Indonesia, Kartikasari Yuliana , Sunaryo Sunaryo ,   Faculty of Economics and Business Universitas Brawijaya, Indonesia, Yuniarinto Agung ,   Faculty of Economics and Business Universitas Brawijaya, Indonesia
Published: September 2021

The quantitative research examines factors affecting the intention to use e-commerce by employing a modified UTAUT2 model. The sample is 263 e-commerce users in Surabaya, Malang, and Kediri who have e-commerce account and know about Sensatia Botanicals. The Data was analyzed using PLS (Partial Least Square) in SmartPLS 3.0. The results of the analysis indicate that performance expectancy, facilitating conditions, social influence, habit, perceived playfulness and price value have a significant positive influence on the behavior intention to use e-commerce, and that effort expectancy and hedonic motivation do not have any significant positive influence. Gender difference in this study can increase the intention of individuals to use e-commerce on the price value factors, while age and income difference in this study neither increase nor decrease the intention of individuals to use e-commerce to purchase the products of Sensatia Botanicals.