bluuebunny/crossref_metadata_2025 huggingface dataset:
A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19
Authors: Zhou Yadi , Hou Yuan , Shen Jiayu , Kalianpur Asha , Zein Joe , Culver Daniel A. , Farha Samar , Comhair Suzy , Fiocchi Claudio , U. Gack Michaela , Mehra Reena , S Stappenbeck Thaddeus , Chan Timothy , Eng Charis , U. Jung Jae , Jehi Lara , Erzurum Serpil , Cheng Feixiong
Published: July 2020

The global Coronavirus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to unprecedented social and economic consequences. The risk of morbidity and mortality due to COVID-19 increases dramatically in the presence of co-existing medical conditions while the underlying mechanisms remain unclear. Furthermore, there are no proven effective therapies for COVID-19. This study aims to identify SARS-CoV-2 pathogenesis, diseases manifestations, and COVID-19 therapies using network medicine methodologies along with clinical and multi-omics observations. We incorporate SARS-CoV-2 virus-host protein-protein interactions, transcriptomics, and proteomics into the human interactome. Network proximity measure revealed underlying pathogenesis for broad COVID-19-associated manifestations. Multi-modal analyses of single-cell RNA-sequencing data showed that co-expression of ACE2 and TMPRSS2 was elevated in absorptive enterocytes from the inflamed ileal tissues of Crohn's disease patients compared to uninflamed tissues, revealing shared pathobiology by COVID-19 and inflammatory bowel disease. Integrative analyses of metabolomics and transcriptomics (bulk and single-cell) data from asthma patients indicated that COVID-19 shared intermediate inflammatory endophenotypes with asthma (includingIRAK3 and ADRB2). To prioritize potential treatment, we combined network-based prediction and propensity score (PS) matching observational study of 18,118 patients from a COVID-19 registry. We identified that melatonin (odds ratio (OR) = 0.36, 95% confidence interval (CI) 0.22-0.59) was associated with 64% reduced likelihood of a positive laboratory test result for SARS-CoV-2. Using PS-matching user active comparator design, melatonin was associated with 54% reduced likelihood of SARS-CoV-2 positive test result compared to angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors (OR = 0.46, 95% CI 0.24-0.86).
SARS-CoV-2 Nucleocapsid Assembly Inhibitors: Repurposing Antiviral and Antimicrobial Drugs Targeting Nucleocapsid-RNA Interaction
Authors: Mukherjee Debica , RAY UPASANA
Published: July 2020

SARS-CoV-2 pandemic has become a serious concern due to high transmission of this virus and unavailability of any definitive drugs yet in clinics. While novel antivirals are under investigation stage, scientists are also rigorously trying to use drug repurposing as an option to fight against this highly infectious novel coronavirus. Several drugs are under regular use for other diseases that are getting screened for their usability against SARS-CoV2. In this study we have targeted SARS-CoV-2 nucleocapsid assembly to shortlist FDA approved drugs that could be tested for inhibition of SARS-CoV-2 virus particles inside the host cell. We could shortlist seven antiviral and anti-microbial drugs. These showed good fit in docking studies inside the RNA binding cleft of the nucleocapsid protein. Also, these drugs have good lipophilic properties suggesting that they would enter the host cells. We propose that these shortlisted drugs could potentially compete out binding of viral RNA to nucleocapsid and thus inhibit successful virus assembly leading to poor virus progeny levels.
Transferable Multi-level Attention Neural Network for Accurate Prediction of Quantum Chemistry Properties via Multi-task Learning
Authors: Liu Ziteng , Lin Liqiang , Jia Qingqing , Cheng Zheng , Jiang Yanyan , Guo Yanwen , Ma Jing
Published: July 2020

The development of efficient models for predicting specific properties through machine learning is of great importance for the innovation of chemistry and material science. However, predicting electronic structure properties like frontier molecular orbital HOMO and LUMO energy levels and their HOMO-LUMO gaps from the small-sized molecule data to larger molecules remains a challenge. Here we develop a multi-level attention strategy that enables chemical interpretable insights to be fused into multi-task learning of up to 110,000 records of data in QM9 for random split evaluation. The good transferability for predicting larger molecules outside the training set is demonstrated in both QM9 and Alchemy datasets. The efficient and accurate prediction of 12 properties including dipole moment, HOMO, and Gibbs free energy within chemical accuracy is achieved by using our specifically designed interpretable multi-level attention neural network, named as DeepMoleNet. Remarkably, the present multi-task deep learning model adopts the atom-centered symmetry functions (ACSFs) descriptor as one of the prediction targets, rather than using ACSFs as input in the conventional way. The proposed multi-level attention neural network is applicable to high-throughput screening of numerous chemical species to accelerate rational designs of drug, material, and chemical reactions.
In Situ Investigation of Interphase and Microstructure Effects on the Chemo-Mechanics of Thiophosphate Solid Electrolytes
Authors: Dixit Marm , Singh Nikhilendra , Horwath James , Shevchenko Pavel , Stach Eric , Arthur Timothy S. , Hatzell Kelsey
Published: July 2020

Lithium thiophosphates (Li3PS4, LPS) are promising solid electrolytes for safe, energy dense solid-state batteries. However, chemo-mechanical transformations within the bulk solid electrolyte and at solidjsolid interfaces can lead to lithium filament formation and fracture-induced failure. The interdependent role of kinetically stable interphases and electrolyte microstructures on the onset and propagation of fracture is not clearly understood. Here, we investigate the effect of interphase chemistry and microstructure on the chemo-mechanical performance of LPS electrolytes. Kinetically metastable interphases are engineered with iodine doping and microstructural control is achieved using milling and annealing processing techniques. In situ transmission electron microscopy reveals how iodine diffuses to the interphase and upon electrochemical cycling pores are formed in the interphase region. Pores/voids formed in the interphase are chemo-mechanically driven via directed ion transport. In situ synchrotron tomography reveals that interphase pore formation drives edge fracture events which are the origin of through-plane fracture failure. Active Li metal has a tendency to fill the fracture region. Cycling lithium in fracture sites leads to localized stress within the solid electrolyte which accumulates and ultimately leads to catastrophic failure. Fractures in thiophosphate electrolytes actively grow toward regions of higher porosity and are impacted by heterogenity in solid electrolyte microstructure (e.g. porosity factor).
Extension of Roles in the ChEBI Ontology
Authors: Hoyt Charles Tapley , Mungall Christopher , Vasilevsky Nicole , Domingo-Fernández Daniel , Healy Matthew , Colluru Viswa
Published: July 2020

This manuscript describes the extension of the ChEBI ontology to connect its roles to their targets in other controlled vocabularies, to improve interoperability, and to enable inference.
Computational Studies to Identify Potential Main Protease Inhibitors for SARS-CoV-19
Authors: Sobhia M. Elizabeth , Ghosh Ketan , Sivangula Srikanth , kumar siva , Singh Harmanpreet
Published: July 2020

The Coronavirus pandemic has put the entire humanity in total shock and has forced the world to go under total lockdown. It is time for the entire scientific community across the globe to find a solution for this deadly and unseen enemy. In silico studies play a vital role in situations like this, as experimental studies are not feasible by all researchers particularly with relevance to BSL4 procedures. In this study, using the high resolution crystal structure of SARS-CoV-2 main protease (PDB: 5R82), we have identified molecules which can potentially inhibit the main protease (Mpro). We used a three-tier docking protocol making use of three different databases. We analysed the residues which are lying near the ligand binding pocket of the main protease structure and it shows a wide cavity, which can accommodate chemically diverse ligands, occupying different sub-pockets. Using the small fragment bound in the 5R82, we have identified several larger molecules whose functional groups make interactions with the active site residues covering. This study also presumably steers the structure determination of many ligand-main protease complexes using x- ray diffraction methods. These molecules can be used as ‘in silico leads’ and further be explored in the development of SARS-CoV-2 drugs.
Enantioselective Chromatographic Analysis of Formoterol Fumarate using Chiral Mobile Phase Additives and Achiral Core-Shell Column
Authors: Pathak Pranav , Mohanraj Krishnapriya
Published: July 2020

A simple, robust, cost-effective, and rapid RP-HPLC method was developed for the separation of enantiomers of formoterol. The separation was achieved by the chiral mobile phase additive technique on an achiral column. Formoterol is a bronchodilator that consists of 50:50 S, S-formoterol and R, R-formoterol. The bronchodilator activity is attributed to R, R-formoterol. Hence, it is important to develop a method to separate the enantiomers of formoterol. Various factors affecting enantiomeric resolution were investigated and optimized. The enantiomers of formoterol were successfully separated with a resolution of 2.57 with a run-time of 9 minutes. The method was validated in accordance with ICH guidelines. The validated method was successfully applied to the marketed formulation of arformoterol.
Electrochemically Driven Desaturation of Carbonyl Compounds
Authors: Gnaim Samer , Takahira Yusuke , Wilke Henrik , Yao Zhen , Li Jinjun , Delbrayelle Dominique , Echeverria Pierre-Georges , Vantourout Julien , Baran Phil
Published: July 2020

Electrochemical techniques have long been heralded for their innate sustainability as efficient methods for achieving redox reactions. Carbonyl desaturation, as a fundamental organic oxidation, is an oft-employed transformation to unlock adjacent reactivity. To date, the most reliable methods for achieving it have relied on transition metals (Pd/Cu) or stoichiometric reagents based on I, Br, Se, or S. Herein we report an operationally simple pathway to such structures from enol silanes and phosphates using electrons as the primary reagent. This electrochemically driven desaturation exhibits a broad scope across an array of carbonyl derivatives, is easily scalable (1-100g), and can be predictably implemented into synthetic pathways using experimentally or computationally derived NMR shifts. Mechanistic interrogation suggests a radical-based reaction pathway.
Distribusi dan Pemetaan Varian-Varian Bahasa Selayar di Kabupaten Sumbawa dan Sumbawa Barat
Authors: Astifaijah Fatma
Published: July 2020

Bahasa merupakan alat komunikasi yang paling ampuh untuk menyatakan identitas suatu kelompok masyarakat. Dengan bahasa, kita dapat memperkuat kepribadian bangsa, mempertebal rasa harga diri, dan sebagai alat kebanggaan nasional serta kesatuan nasional.Di wilayah  Nusa Tenggara Barat, bahasa yang digunakan secara garis besar ada empat bahasa yaitu bahasa Bali, bahasa Sasak, bahasa Sumbawa, dan bahasa Bima. Di samping itu ada bahasa lain seperti bahasa Jawa, bahasa Bugis, bahasa Selayar, dan bahasa Sunda yang jumlah pemakainya tidak sebesar empat bahasa tersebut. Salah satu bahasa yang dijadikan sebagai bahan penelitian adalah bahasa Selayar. Bahasa Selayar merupakan salah satu variasi dialek dari bahasa Makasar. Bahasa Selayar di Provinsi Nusa Tenggara Barat hanya ada di daerah pesisir pantai Sumbawa Barat dan Sumbawa Besar.
Distribusi dan Pemetaan Varian-Varian Bahasa Sasak di Kabupaten Dompu dan Bima
Authors: Hakim Lukmanul
Published: July 2020

Adanya pemukiman-pemukiman Sasak dalam rentang waktu yang cukup lama di tengah-tengah komunitas Mbojo akan berdampak pada situasi kebahasaan pada kedua bahasa komunitas tersebut. Keadaan seperti itu akan menyebabkan kontak bahasa yang akan menimbulkan saling memengaruhi/saling meminjam satu sama lain. Variasi-variasi lingual akan menyebabkan perbedaan bahasa yang bersangkutan secara geografis dengan bahasa asalnya. Penelitian ini bertujuan membuat deskripsi yang lengkap tentang: variasi-variasi bahasa Sasak, hubungan kekerabatan antarvarian bahasa tersebut, dan sebaran geografisnya di Kabupaten Dompu dan Bima.
Distribusi dan Pemetaan Varian-Varian Bahasa Madura di Kabupaten Sumbawa
Authors: Maerina Ryen
Published: July 2020

Makalah ini mengkaji distribusi dan pemetaan varian-varian bahasa Madura di Kabupaten Sumbawa, dengan menggunakan pendekatan dialektologi.Ada tiga kantong bahasa (enklave) Madura di Kabupaten Sumbawa, yaitu di Kelurahan Brang Bara, Kelurahan Bugis, dan Desa Luar. Jumlah etnis Madura yang menghuni ketiga kantong bahasa tersebut sebanyak 222 kepala keluarga.Bahasa Madura yang ada di Kabupaten Sumbawa memiliki tiga dialek, yaitu DBB (dialek Brang Bara), DBs (dialek Bugis), DL (dialek Luar). Secara kualitatif, hubungan kekerabatan diantara ketiganya dinyatakan dengan hubungan dialek, yang meneruskan satu bahasa induk, yaitu Prabahasa Madura Sumbawa (PMS). DBB dengan DBs memiliki hubungan kekerabatan yang lebih tinggi daripada DBB dengan DL ataupun DBs dengan DL. Pada fase historis tertentu DBB dan DBs diduga sebagai subdialek dari satu dialek yaitu dialek DBBBs (dialek Brang Bara Bugis). Dalam perkembangan bahasa Madura Modern, kedua subdialek itu muncul sebagai dialek yang berdiri sendiri.
Distribusi dan Pemetaan Varian-Varian Bahasa Bajo di Pulau Lombok
Authors: Yudiastini Ni Made
Published: July 2020

Bahasa daerah merupakan alat komunikasi intraetnik yang berfungsi sebagai penanda jati diri atau lambAng identitas pemakai  bahasa yang bersangkutan. Sebagai bahasa yang hidup, bahasa daerah mempunyai kedudukan dan fungsi yang penting bagi masyarakat penuturnya dalam kegiatan kemasyarakatan atau kebudayaan. Penelitian tentang bahasa daerah perlu dilakukan mengingat pentingnya pendokumentasian pemetaan bahasa-bahasa di seluruh Indonesia. Penentuan dialek atau subdialek bahasa Bajo pun dilakukan dengan menggunakan metode dialektometri yang penekanannya pada sebaran geografis dan jumlah varian serta jumlah penutur bahasa bajo yang ada di pulau Lombok. Bahasa Bajo di pulau Lombok dapat dikelompokan menjadi dua dialek, yaitu dialek Bajo Keruat (DBK) dan dialek Bajo Tanjung (DBT).
Filsafat Nggusu Waru dalam Tradisi Lisan Bima dan Relevansinya dengan Ciri Kepemimpinan Modern
Authors: Badrun Ahmad
Published: July 2020

Dalam tulisan ini dibahas relevansi isi filsafat Nggusu Waru dengan ciri kepemimpinan modern dan penyebab masyarakat Bima melupakan filsafat itu. Pembahasan ini dilakukan dengan metode semiotik. Hasil kajian menunjukkan bahwa 8 butir filsafat Nggusu Waru mempunyai nilai yang sama dengan ciri kepemimpinan modern, yaitu (1) matoqa đi Ruma labo Rasu (yang taat kepada`Allah dan Rasul) adalah sama dengan percaya kepada Tuhan yang Mahaesa, (2) maloa ro þade ‘yang pandai dan cerdas’ adalah sama dengan berwawasan luas, (3) mantiri nggahi kalampa ‘yang jujur dalam melaksanakan tugas’ adalah sama dengan kejujuran, (4) mapoda nggahi paresa ‘yang mampu menegakkan kebenaran’ adalah sama dengan adil, (5) mambani ro disa ‘yang bertanggung jawab dan berani’ adalah sama dengan berani menanggung risiko, (6) matenggo ro wale ‘sehat jasmani dan rohani serta kuat’ adalah sama dengan sehat jasmani dan rohani, (7) maþisa ro guna ’berwibawa dan sakti’ adalah sama dengan berwibawa atau berpengaruh, dan (8) londo dou taho ‘keturunan orang baik-baik’ adalah sama dengan bermoral baik. Filsafat itu tidak lagi populer karena masyarakat Bima kurang apresiatif terhadap tradisi lisannya.
Kontak Bahasa antara Komunitas Tutur Bahasa Selayar dan Bahasa Sumbawa di Kabupaten Sumbawa dan Sumbawa Barat
Authors: Astifaijah Fatma
Published: July 2020

Penelitian kontak bahasa Selayar dan bahasaSumbawamerupakan salah satu kajian sosioliguistik. Dalam tulisan ini, melibatkan dua unsur, yaitu unsur sosial dan unsur kebahasaan yang terjadi pada masyarakat bilingual dan multilingual dengan cara melakukan adaptasi sosial dan adaptasi linguistik.Adaptasi sosial diperoleh hasil bahwa masyarakat tutur bahasa Selayar dan bahasaSumbawadi daerah sampel dapat menyesuaikan diri dengan masyarakat tutur di mana mereka berada. Adaptasi linguistik digambarkan bahwa masyarakat tutur bahasa Selayar dan bahasa Sumbawa melakukan serapan secara timbal balik dalam bahasa Sumbawa, bahasa Selayar, dan bahasa Indonesia dengan bentuk fonologi, leksikon, baster, dan morfologi. Alih kode dan campur kode dalam bahasa Indonesia terjadi pada kedua masyarakat tutur bahasaSumbawadan Selayar. Hal ini disebabkan kedua masyarakat tutur bahasa tidak seutuhnya paham akan bahasa yang mereka gunakan, maka secara otomatis mereka akan beralih kode atau bercampur kode dengan bahasaIndonesia.Hal tersebut mengakibatkan diperolehnya hasil kecenderungan adaptasi berpengaruh pada bahasa yang dominan dan bervariasi dengan berbagai faktor antara lain geografi, sosial, budaya, usia, ekonomi, pendidikan, dan prestise (harga diri) pada setiap daerah pengamatan yang berbeda.
Analisis Wacana Kritis dan Studi Bahasa Kritis dalam Pengajaran BIPA
Authors: Hwita Ganjar
Published: July 2020

Kerangka kerja analisis wacana kritis (AWK) relevan untuk pendekatan kritis terhadap studi bahasa—yang dikenal dengan studi bahasa kritis (SBK). SBK merupakan satu sumbangan penting dalam pendidikan dan pembelajaran bahasa yang mulai terkenal sekitar tiga dekade yang lalu.  Relevansi AWK dengan SBK terletak pada orientasi atau pandangan terhadap bahasa dalam pendidikan dan pembelajaran bahasa (R. Fowler, et., 1979; M. Pecheux, 1982; J. Mey, 1985; N. Fairlough, 1989).Dalam AWK, setiap wacana memiliki tiga dimensi: merupakan teks bahasa lisan maupun tertulis; suatu interaksi antar-orang—yang melibatkan proses produksi dan interpretasi teks (praktik kewacanaan); dan merupakan bagian dari suatu praktik atau tindak sosial.  Implikasinya dalam SBK adalah bagaimana studi ini mengangkat kaidah bahasa dan praktik kebahasaan ditanamkan bersama dengan hubungan suatu praktik atau tindak sosial yang sering tidak disadari oleh kita selama ini.  Studi ini pun mengkritik kecenderungan studi bahasa yang menggunakan kaidah dan praktik kebahasaan dengan begitu saja, sebagai objek yang dideskripsikan, dalam cara yang mengaburkan penanaman ideologi dan politik mereka.Makalah ini akan membahas dalam tataran ide suatu pemikiran bidang AWK dalam hubungannya dengan SBK tentang pengajaran suatu bahasa sebagai bahasa asing (N. Fairlough, 1989; C. Wallace, 1992). Masalahnya difokuskan pada pengajaran membaca dengan latar belakang seringnya pelajar BIPA dianggap rendah sebagai pembaca sehingga ada yang hilang dalam pembelajarannya.  Apa yang hilang itu adalah (1) usaha mendudukkan kegiatan membaca dan teks tulis dalam konteks sosial, (2) penggunaan teks yang provokatif, (3) cara penafsiran teks yang melibatkan asumsi-asumsi ideologis serta makna proposisional.
Kontak Bahasa antara Komunitas Tutur Bahasa Sasak dan Komunitas Tutur Bahasa Mbojo di Kabupaten Dompu dan Bima
Authors: Hakim Lukmanul
Published: July 2020

Penelitian  ini mendeskripsikan tentang wujud adaptasi linguistik antarkomunitas Sasak dan Mbojo di Kabupaten Dompu dan Bima, kecenderungan adaptasi linguistik pada kedua komunitas tersebut, segmen sosial pada masing-masing komunitas tutur bahasa tersebut yang lebih dominan melakukan adaptasi linguistik, dan faktor-faktor penyebab terjadinya adaptasi linguistik pada kedua masyarakat etnis tersebut.Secara metodologis, wujud data yang menjadi basis analisis dalam penelitian ini adalah berupa data kebahasaan dalam masing-masing bahasa komunitas tutur yang menjadi sasaran penelitian. Ada dua wujud data yang menjadi bahan analisis dalam penelitian ini, yaitu data linguistik dan data nonlinguistik. Data linguistik dikumpulkan dengan cara mewawancarai informan di setiap lokasi pengambilan data yang ditentukan, sedangkan  data sosiolinguistik dikumpulkan dengan cara peneliti langsung datang ke lokasi penelitian dengan mewawancarai dan menyebarkan kuesioner pada informan. Selanjutnya, data yang diperoleh dianalisis. Untuk analisis data linguistik dilakukan dengan menggunakan metode padan, sedangkan untuk memperoleh gambaran ihwal kecenderungan adaptasi bahasa pada komunitas yang menjadi sampel penelitian digunakan analisis kuantitatif, dengan menghitung persentase kemunculan bentuk adaptasi linguistik pada semua variabel yang menyangkut pentipean informan.Hasil penelitian ini menunjukkan bahwa adaptasi linguistik yang terdapat pada komunitas Sasak dan Mbojo secara kuantitatif memperlihatkan adanya adaptasi linguitik yang sangat terbatas, itu pun sebagian besar pada tataran leksikon. Penyebabnya  bahasa Sasak memiliki hubungan kesubrumpunan bahasa yang berbeda dengan bahasa Mbojo, umur enklave Sasak yang menjadi daerah penelitian masih relatif muda, masing-masing komunitas memandang isoleknya sangat berprestise, dan mayoritas penduduk ketiga enklave yang menjadi sampel penelitian adalah petani.
Distribusi dan Pemetaan Bentuk/Jenis Karya Sastra yang Tumbuh dan Berkembang pada Masyarakat Tutur Bahasa Bugis di Kabupaten Sumbawa
Authors: Bahri Syaiful
Published: July 2020

Tulisan ini akan menggambarkan dua hal, yaitu: (1) deskripsi bentuk dan jenis karya sastra yang tumbuh dan berkembang pada masyarakat tutur bahasa Bugis di KabupatenSumbawa; (2) distribusi dan penyebaran karya sastra tersebut.Dari hasil analisis data ditemukan dua ragam karya sastra, yaitu prosa dan puisi. Dari ragam prosa ditemukan dua jenis karya sastra, yaitu dongeng dan legenda yang kesemuanya ditemukan di kedua daerah pengamatan. Pengelompokan lebih khusus menunjukkan, di Teluk Santong hanya ditemukan jenis dongeng lelucon, sedangkan di Labuan Mapin ditemukan tiga jenis dongeng, yaitu lelucon, fabel, dan dongeng biasa. Jenis legenda di Teluk Santong hanya legenda setempat, sedangkan di Labuan Mapin ditemukan legenda perorangan, keagamaan, dan alam gaib.Ragam puisi ditemukan jenis pantun (kélong) dan mantra (jappi). Jenis pantun ditemukan di kedua daerah pengamatan, sedangkan jenis Mantra hanya ditemukan di Labuan Mapin.
REDUPLIKASI DALAM BAHASA BUGIS DIALEK SINJAI
Authors: S.S., M.A. Herawati
Published: July 2020

AbstractThe purpose of the research is to identify the forms of reduplication in Sinjai Bugineses dialect and also its meaning and its function. This research is a qualitative descriptive research. Data source is the forms of reduplication of the Sinjai Buginese dialect used in daily communication. Data collection techniques uses read and note techniques, while the data analysis method uses sharing method by Immediate Constituent Analysis technique. The result of this study founds some forms of reduplication in Sinjai Buginese dialect as follows: (a) full reduplication, (b) partial reduplication, (c) reduplicative affixes, and (d) initial reduplication. Reduplication can be used to form new words, e.g to form nouns, while it may be used to denote a number of things such as number (plurality, distribution, collectivity), distribution af an argument, tense, aspect, intensity, conditionality, reciprocity, and pretense. Keywords: reduplication, Bugis language, meaning, Sinjai dialect AbstrakPenggunaan bahasa Bugis di Kabupaten Sinjai selain sebagai alat komunikasi sehari-hari, juga sebagai sarana pendukung kebudayaan penuturnya. Penelitian ini bertujuan mengidentifikasi bentuk-bentuk reduplikasi dalam bahasa Bugis dialek Sinjai beserta fungsi dan maknanya. Penelitian ini merupakan penelitian deskriptif kualitatif. Sumber data berupa bentuk-bentuk reduplikasi yang digunakan oleh penuturnya dalam kehidupan sehari-hari. Teknik pengumpulan data yang digunakan adalah teknik simak dan catat, sedangkan metode analisis data menggunakan metode agih dengan teknik pilah unsur langsung. Berdasarkan hasil analisis diperoleh gambaran bentuk-bentuk reduplikasi dalam bahasa Bugis dialek Sinjai, yaitu: (a) reduplikasi seluruh, (b) reduplikasi sebagian, (c) reduplikasi berimbuhan, dan (d) reduplikasi berubah bentuk. Reduplikasi berfungsi membentuk nomina sedangkan maknanya adalah menyatakan perbuatan frekuentatif, perbuatan untuk beberapa saat lamanya, perbuatan yang dilakukan dengan tidak serius atau gerak sedikit, perbuatan saling, makna agak, makna benda yang menjadi objek atau alat, makna keadaan atau sifat yang disebut oleh bentuk dasar, makna bermacam-macam, makna kumpulan, makna menyerupai atau seperti, makna tiap-tiap, makna intensitas, makna perbandingan sangat atau paling, dan makna hanya atau cuma.Kata Kunci: reduplikasi, bahasa Bugis, makna, dialek Sinjai
Narrativas de professores alfabetizadores em início de carreira: experiências e aprendizagens construídas
Authors: De Sousa Ana Luiza Floriano , França-Carvalho Antonia Dalva
Published: July 2020

resumo
El paradigma de la investigación en artes ¿debate o realidad?
Authors: Cabana Bezpalov Emiliano
Published: July 2020

En este diálogo con el profesor Dr. Henk Borgdorff, de la Universidad de Leiden (Países Bajos), nos proponemos revisitar el estado actual del debate sobre la investigación en artes ─o basada en la práctica─ en Europa y sus posibles conexiones con América Latina.

Si bien es un proceso que sigue emergiendo en los ámbitos académicos y profesionales, proponemos abrir nuevas perspectivas que fomenten la práctica artística como investigación.
Surfando na Sociedade da Informação e do Conhecimento: a questão das competências docentes
Authors: Maia do Amaral Mirian , Goulart Vilarinho Lúcia Regina
Published: July 2020

O artigo ressalta o desafio de se educar na cibercultura, quando os alunos constituem o centro da ação educativa e o professor, uma das muitas fontes de informação a que eles recorrem. Este professor, para responder às demandas educacionais, precisa atualizar-se constantemente, o que implica domínio de um conjunto de saberes/ competências necessários ao exercício da docência, de modo a garantir uma atuação proficiente, capaz de enfrentar os desafios impostos por uma sociedade marcada pela incerteza, instantaneidade e rapidez das mudanças. Decorre daí a necessidade de se identificar e mapear as competências docentes, cujo repertório deve estar sintonizado com o contexto e as estratégias da instituição onde esse ator exerce suas atividades.
O ensino médio em questão: A análise de uma história recente
Authors: De Oliveira Ramon
Published: July 2020

Analisa-se a história recente do ensino médio brasileiro (1971-2006), tendo como referência as modificações ocorridas no sistema capitalista e suas implicações na prática pedagógica escolar e no financiamento da educação pública brasileira. Considera-se que nesse período, além da expressiva expansão das matrículas nas escolas das redes estaduais, foi pródigo o debate sobre a identidade social do ensino médio. Destaca-se que, em meio ao embate político entre a academia e setores ligados ao ensino tecnológico e o Governo Federal no referente à garantia da não dissociação entre a formação geral e profissional no ensino médio, mantém-se a indefinição da identidade social do ensino médio.
Trabalho e Vida Pessoal: O Equilíbrio Necessário
Authors: Valmorbida Stepansky Daizy , França Lucia
Published: July 2020

Este artigo descreve o cenário da globalização e suas implicações no processo de trabalho. Os autores enfatizam a importância dos programas de equilíbrio entre o trabalho e a vida pessoal, e seus benefícios para os trabalhadores, organizações e sociedade. Eles analisam ainda o número de horas dedicadas ao trabalho, especialmente entre os executivos, mulheres e trabalhadores mais velhos, e as mudanças de atitudes necessárias para aumentar o bem-estar, a motivação e a produtividade. Algumas sugestões são apresentadas de forma a incluir os programas de equilíbrio trabalho e vida pessoal nas agendas organizacionais.
Atividades educativas na Saúde na perspectiva da educação permanente em um município de Goiás
Authors: Grego Maia Ludmila , De Sousa Lucilene Maria , Almeida da Silva Luiz , Carvalho Francescantonio Menezes Ida Helena
Published: July 2020

Objetivou-se analisar as atividades educativas na rede municipal de saúde na perspectiva da Política Nacional de Educação Permanente em Saúde. Estudo retrospectivo, descritivo, documental, realizado em um município do Sudoeste Goiano. Foram analisadas 82 atividades educativas, ocorridas no ano de 2012, das quais 80,5% se deram com ênfase na educação na saúde voltada à comunidade. Houve predominância das metodologias tradicionais de ensino em 67,6% e a origem das atividades educativas se deu na maior parte por demandas internas ao serviço, 86,6%. Observa-se que, embora haja esforços contínuos para mudanças, implementar a política é um desafio, devido à sua complexidade político-pedagógica no contexto do Sistema Único de Saúde.
As trajetórias dos egressos do ensino médio integrado em Agropecuária: rumo ao trabalho ou ensino superior?
Authors: Ferreira Danilo José , Raitz Tania Regina , Vanzuita Alexandre
Published: July 2020

O artigo busca compreender a trajetória acadêmica e de trabalho de jovens egressos do Ensino Técnico em Agropecuária do IFC, por meio de abordagem qualitativa. Utilizou-se de pesquisa bibliográfica, questionário e entrevista individual com 24 ex-alunos. Os pressupostos teórico-metodológicos desenvolvidos estão fundamentados na categoria trabalho (perspectiva ontológica) e juventude como diversidade. Os resultados demonstram que essa oferta de ensino profissional está servindo mais como passagem para a realização de outros cursos não associados à área do que direcionando para o trabalho agropecuário.
Formare: construção de projetos de vida
Authors: Da Silva José Edson
Published: July 2020

Este estudo apresenta um projeto social idealizado e conduzido por uma Organização da Sociedade Civil de Interesse Público (OSCIP), cuja finalidade é promover cursos de formação básica para jovens em condição socioeconômica vulnerável, para, com isso, promover a integração entre empresa e comunidade. Por meio da construção de projetos de vida, nos quais os jovens são estimulados a aprender não só a fazer uma escolha profissional, mas também aprender como fazer escolhas por toda a vida, os elementos estruturais são a Orientação Profissional e a perspectiva da Análise Institucional.
A gestão do trabalho pedagógico em espaços escolares e não escolares: um debate acerca da formação do pedagogo no Brasil
Authors: Calegari-Falco Aparecida Meire , Alves da Silva Moreira Jani
Published: July 2020

Este artigo refere-se a uma pesquisa sobre a formação do pedagogo e suas novas funções, especificamente a atuação nos espaços escolares e não escolares. Apresenta um breve panorama das transformações ocorridas no mundo do trabalho, que determinaram novas exigências para a formação do pedagogo no campo da docência e nos espaços não escolares. Diante das mudanças ocorridas na formação inicial do pedagogo, apresenta as definições concretizadas em leis e suscita o debate diante do contexto de precarização do trabalho docente e dos novos conhecimentos e fazeres atribuídos ao pedagogo.
Base Nacional Comum Curricular – debates e movimentos
Authors: Cordão Francisco Aparecido
Published: July 2020

Professor Francisco Aparecido Cordão entrevista Alice Ribeiro
O processo de inclusão de alunos com deficiência no interior de São Paulo: entre professores de Educação Física e polivalentes
Authors: Da Conceição Oliveira Érica Fernanda , Pereira de Moraes João Carlos
Published: July 2020

A elaboração de mecanismos para subsidiar a inclusão de alunos com deficiência no ambiente escolar é o tema deste artigo, que procura compreender os principais aspectos no processo de inclu­são, em uma rede municipal de São Paulo, analisando os discursos de professores de Educação Física e polivalentes. Foram entrevis­tadas e acompanhadas em suas aulas professoras que lecionam para os mesmos alunos com deficiência e observou-se que elas apresentam as mesmas dificuldades (infraestrutura, falta de forma­ção, apoio pedagógico) e potencialidades (planejamento adapta­do e práticas de socialização).
Tecnologia exponencial e os novos desafios da sociedade contemporânea
Authors: Borges Corrêa Sílvia , Jacubowski Correia Dubeux Veranise , Terra Simone , Jacques Daniela
Published: July 2020

Veranise Jacubowski Correia Dubeux, Sílvia Borges Corrêa, Daniela Jacques e Simone Terra entrevistam Marcos Cavalcanti
PERSONAL AND PROFESSIONAL DEVELOPMENT OF FUTURE EDUCATORS IN THE PROCESS OF EDUCATIONAL PRACTICES
Authors: Ivaniuk Hanna , Venhlovska Olena , Antypin Yevhen
Published: July 2020

The article highlights the features of content and technology support of personal and professional development of future teachers in the process of educational practices. Abovementioned ideas are presented here in an anthropological dimension. Personal and professional development of students is shown as a process aimed at modelling the personal and professional qualities of future teachers, ability and willingness for development and self-development. Specifics that have been named are for producing new ideas and practices based on acquired knowledges for creation own trajectory of professional development. The value-personal, search and research, reflective components and the 21st century skills are defined as important components of personal and professional development of students. The exploration describes empirical results of research on the formation of abovementioned components in students of specialties «Preschool education» and «Primary education» before their practices. It has been found that future teachers strive for personal and professional development however they don’t have enough skills to plan their actions of self-development.
According to the empirical results of this study the scientific and pedagogical staff of Department of Pedagogy and Psychology of Pedagogical institute of Borys Grinchenko Kyiv University developed programs and recommendations for the organization of educational practices. The article describes the content, forms, methods of development of components of personal and professional development of students in the course of educational practices conducted in the preschool and primary school institutions in Kyiv. The essence of such interactive forms as: a roadmap, reflection, a blog, an individual portfolio of personal and professional growth is revealed. The proposed forms of work contribute to the students’ willingness to evaluate the results of their professional activity, to form the ability to work as a team and alone, to be openminded to the opinions of others in educational space, to find new ways of solving pedagogical goals, etc. The empirical results of the study show the positive dynamics of students’ development in value-personal, search and research, reflective components and 21st century skills in the course of proposed forms of work. This testifies to the effectiveness of the created content and technology support for the development of components of personal and professional development of students in the process of educational practices.
PRACTICES AND CHALLENGES OF PUBLIC AND PRIVATE PRESCHOOLS OF JIGJIGA CITY ADMINISTRATION
Authors: Haile Yigzaw , Mohammed Abdirahman
Published: July 2020

The main purpose of this study was to assess practices and challenges of preschool education in Jijiga City administration. Mixed design was employed (both quantitative and qualitative) for this study. 19 preschool centres (6 public and 13 private preschools) were randomly selected for the study. 51 preschool teachers (12 teachers from public and 39 teachers from private teacher) were selected.  A semi-structured questionnaire was used to collect quantitative data in which 57 items were filled by preschool teachers which are dealing with Early Childhood Care and Education (ECCE) practices. Interview, FGD, observation and document analysis were used to triangulate the data collected using questionnaire. Percentage and thematic analysis were used to analyze the quantitative and qualitative data respectively. The main findings revealed that preschool practices in all sampled preschools were found to be below standard, unable to use local stories since teachers were not from the community and knowledge of parents, teachers and principals towards contribution of the preschool was found to be limited. It was found that 82.4% of the preschool had no early childhood care and education qualification, and 70.6% of the preschool teachers did not agreed that all sampled preschools had inadequate classroom space, 64.7% of the preschool centres did not have age appropriate chairs. Similarly, 76.5 % of the preschool had no any out-door playing material and 100 % of all preschool did not used approved curriculum and lack of appropriate teaching used in most of the preschool were some of the main finding.  The Ethiopia Somali Regional Education Bureau is recommended to address shortage of trained ECCE teachers, develop standardized ECCE curriculum, applying developmentally appropriate content, materials, and teaching methods, use locally and culturally appropriate materials and assign teachers who can speak the local language of the community.
STUDI KEBERLANJUTAN LAYANAN ANGKUTAN PENYEBERANGAN WILAYAH KEPULAUAN
Authors: Amriardi Ulil , Buana IGN Sumanta
Published: July 2020

Angkutan Penyeberangan di Kuala Tungkal – Dabo Singkep sangat penting, karena berperan penting sebagai penghubung utama antara kedua pulau tersebut dengan wilayah di sekitarnya. Permasalahan muncul ketika kapal menjalani perawatan tahunan (docking) dan sewaktu-waktu kapal mengalami kerusakan, sehingga layanan penyeberangan terhenti dan terputus. Tujuan dari penelitian ini adalah untuk mengetahui dan mencari bagaimana cara mempertahankan layanan angkutan penyeberangan disaat kapal penyeberangan di lintasan Kuala Tungkal – Dabo Singkep tidak beroperasi. Selain itu penelitian ini juga bertujuan untuk mencari alternatif pengoperasian kapal yang dapat memaksimalkan waktu operasional kapal. Penelitian ini dilakukan dengan menganalisis pola operasi kapal penyeberangan di sekitar kedua lintasan tersebut. Skenario yang dikembangkan adalah dengan memperhatikan batasan waktu dan jarak tempuh di rute yang ada. Skenario yang terpilih adalah dengan mengoperasikan KMP Kundur yang semula beroperasi di lintasan Tanjung Pinang – Dabo Singkep menjadi Tanjung Pinang – Dabo Singkep – Kuala Tungkal. Skenario ini dapat dipakai untuk menggantikan KMP Sembilang saat tidak beroperasi. Biaya operasional kapal pengganti ini adalah sebesar Rp.57.587.626,- per round trip.
PEMANFAATAN ENERGI TERBARUKAN SEBAGAI SUMBER ENERGI LISTRIK PADA DESAIN KAPAL WISATA DI KEPULAUAN RIAU
Authors: Ariyanto Danang , Satoto Sapto Wiratno
Published: July 2020

Energi terbarukan dan energi yang berkelanjutan adalah isu yang selalu dibahas dalam konferensi tingkat lokal dan dunia. Isu lingkungan tersebut diangkat guna tetap menjaga bumi sebagi tempat tinggal ini tetap terjaga dalam waktu yang lama. Pemanfaatan energi tersebut dalam banyak sektor menjadi semacam keharusan yang akan membawa dampak kepada kebaikan. Sektor wisata merupakan salah satu sektor yang dekat dan ungkin bisa berefek luas karena di sektor wisata tersebut orang akan datang dari berbagai tempat untuk kemudian menemukan sebuah hal baru di tempat yang mereka kunjungi. Kepulauan Riau yang berbatasan langsung dengan luar negeri memiliki potensi yang besar untuk menjadi mengenalkan pemanfaatan teknologi terbarukan di sektor wisata salah satunya dengan membuat kapal wisata dengan suplai tenaga berasal dari energi terbarukan dan berkelanjutan tersebut tersebut
THE SIMULATION OF SKEG EFFECT TO BARGE RESISTANCE CALCULATION USING CFD-RANS OPENFOAM
Authors: Hasmi Abrari Noor , Nurcholik Samsu Dlukha
Published: July 2020

The paper discusses the significance of different types of skegs in a barge toward the pressure, fluid velocity and the ship’s total resistance. There are three kinds of skeg configurations: barge without skegs, skegs without deflection, and skegs with deflection. The barge was towed with forward speed were ranging across 3 knots – 9 knots. The simulations were conducted using an open-source RANS (Reynold Averaged Numerical Simulation) CFD code Open-FOAM. The simulations show that the skegs raise the barge’s resistance. The skegs with deflection have a bigger resistance amplification compared to skegs without deflection.
Sistem Monitoring Putaran Generator Pada Pembangkit Listrik Tenaga Arus Laut
Authors: Marta Eko , Miftah Miftah , Mintarso Cahyadi Jati
Published: July 2020

Dalam rangka pengembangan energi alternatif untuk pembangkit energi listrik, maka telah dilakukan penelitian pemanfaatan energi arus laut sebagai pembangkit energi listrik terbarukan. Untuk menghasilkan energi listrik dibutuhkan sebuah generator yang digerakkan oleh arus laut melalui blade turbin yang dipasang didalam laut. Berdasarkan pemetaan / survei yang telah dilakukan dapat diketahui besarnya arus laut yang ada di perairan indonesia. Dari hasil survei maka generator yang digunakanadalah type Low Speed agar didapatkan konversi energi yang optimal. PMG 3500 adalah generator low speed dengan permanen magnet mempunyai  kapasitas sampai 3500 VA. Dari data sheet PMG 3500dapat diketahui bahwa putaran maksimal  yang diijinkan adalah 250 Rpm dan bila melebihi putaran maksimalnya akan menyebabkan kerusakan pada belitan generator tersebut. Untuk mengantisipasi kondisi tersebut maka putaran generator harus di monitoring karena generator tersebut tidak dilengkapi dengan sistem pengaman terhadap over speed. Sistem monitoring ini menggunakan Rotari encoder sebagai sensor pendeteksi Rpm generator dan rangkaian mikrokontroller untuk memproses data darirotary encoder agar bisa ditampilkan dalam display LCD.
Ethnic labels, pride, and challenges: A qualitative study of Latinx youth living in a new Latinx destination community
Authors: Corona Rosalie , Velazquez Efren , McDonald Shelby E. , Avila Melissa , Neff Molly , Iglesias Adam , Halfond Raquel
Published: July 2020

Most of the literature on Latinx youths’ ethnic identity development has been conducted in communities with a large Latinx population. Fewer studies have examined Latinx youths’ ethnic identity in communities with a smaller yet rapidly growing Latinx population (i.e., new Latinx destination communities). Twenty-five Latinx youth (10-15 years)living in a new Latinx destination community participated in semi-structured interviews to identify the ethnic labels they use to describe themselves (i.e., ethnic-identity self-identification) and explore their feelings about being Latinx (i.e., ethnic-identity affirmation). Using an existing coding scheme, we found that most immigrant youth used a national origin label alone, while U.S.-born youth used a pan-ethnic term alone or in combination with an American term. Results of the thematic analysis exploring youths’ ethnic identity affirmation indicated three themes among youths’ account of their ethnic affirmation: (a) pride; (b) communication difficulties; and (c) discrimination. Study findings have implications for examining Latinx youth ethnic identity development in new destination communities.
The Opinions of Gifted Students about Leadership Training
Authors: Ogurlu Uzeyir , Sevim Mehmet Naci
Published: July 2020

The aim of this research was to identify gifted middle school students’ opinions and suggestions about leadership and leadership education. For this purpose, 65 gifted middle school students who have been attending the Science and Art Center were interviewed by using the focus group. The gifted students were asked open-ended questions about leadership and leadership training. Qualitative content analysis was employed. The results of the focus group interviews showed that majority of gifted students did not want to be a leader in the future because of some reasons including lack of self-confidence and avoiding taking responsibility. But the majority believed that leadership could be improved through training and wanted to participate in leadership training in schools. The participants suggested some various ways for leadership improvement of students in the schools such as teamwork or giving responsibilities.
Anti-inflammatory Activity of Piperlotines
Authors: Ramírez-Marroquín Oscar Abelardo , Jiménez-Arellanes María Adelina , Luna-Herrera Julieta , Olivares-Romero José Luis , Bonilla-Landa Israel , Castro-Cerritos Karla Viridiana
Published: July 2020

Abstract. In the present study we evaluated six α,β-unsaturated amides named piperlotines (for being isolated originally from Piper species) as new in vivo anti-inflammatory agents. In addition, we report the mechanosynthesis of two of them by mechanochemical activation of a Horner-Wadsworth-Emmons reaction. The reaction of β-amidophosphonate 4, an aromatic aldehyde and K2CO3 under grinding in a mortar and pestle afforded piperlotines 5-6 in good yields (70-88%) in short reaction times, obtaining only (E)-diastereomer. Piperlotines previously prepared were tested as anti-inflammatory and antibacterial agents. In this respect, derivatives 2 and 6 exhibited excellent in vivo anti-inflammatory activity on mice, especially trough topical administration (TPA acute inflammation model). Furthermore, piperlotine A, and compounds 2 and 6 had slight antimycobacterial activity against Mycobacterium tuberculosis (MIC = 50 µg/mL). In conclusion, the solvent-free mechanosynthesis of piperlotines produced valuable compounds that could serve as templates for further investigation in the search of better drug-like compounds for the treatment of inflammatory diseases.  
Resumen. En la presente investigación se evaluó la actividad anti-inflamatoria in vivo de seis amidas α,β-insaturadas, identificadas en la literatura como piperlotinas debido a su inicial aislamiento a partir de especies vegetales del género Piper (como las pimientas). La reacción del β-amidofosfonato 4 con un aldehído aromático y K2CO3 en molienda con mortero y pistilo produjo las piperlotinas 5-6 con buenos rendimientos (70-80%) en tiempos cortos de reacción, obteniendo solamente el diastereoisómero (E). Las piperlotinas preparadas se evaluaron como agentes anti-inflamatorios y antibacterianos, observando excelente actividad anti-inflamatoria para los derivados 2 y 6, especialmente cuando se probaron mediante administración tópica (modelo de inflamación aguda por TPA). Además, la piperlotina A y los derivados 2 y 6 mostraron actividad antibacteriana contra Mycobacterium tuberculosis (MIC = 50 µg/mL). En conclusión, la síntesis de piperlotinas a través de molienda en condiciones libres de disolvente generó importantes productos que pueden ser utilizados como punto de partida para generar nuevos compuestos bioactivos para el tratamiento de padecimientos relacionados con la inflamación.