bluuebunny/crossref_metadata_2025 huggingface dataset:
Toolkit for integrating millimeter-sized microfluidic biomedical devices with multiple membranes and electrodes
Authors: Tao Xudong , Naegele Tobias E. , Rognin Etienne , Willis-Fox Niamh , Oldroyd Poppy , Dong Chaoqun , Kissovsky Stefany , Dominguez-Alfaro Antonio , Velasco-Bosom Santiago , Daly Ronan , Malliaras George G.
Published: February 2025

In recent years, microfluidic systems have evolved to incorporate increasingly complex multi-layer and multi-material structures. While conventional 2-dimensional microfluidic systems are typically fabricated with lithographic techniques, the increase in system complexity necessitates a more versatile set of fabrication techniques. Similarly, although 3D printing can easily produce intricate microfluidic geometries, integrating multiple membranes and electrode components remains challenging. This study proposes a toolkit for fabricating free-standing 3-dimensional microfluidic systems for biomedical devices, incorporating flow channels, electrodes, and membranes. The fabrication techniques include molding separation using 3D printed molds, laser-based processing, and component assembly, each achieving micron resolution. Here, we introduce a novel approach to integrate membranes into microfluidics by directly curing elastomer-based microfluidics with the membrane through replica molding, while preserving membrane functionality by effectively removing elastomer residues through reactive ion etching. The resulting membrane-elastomer microfluidic component significantly simplifies the assembly of intricate microfluidic systems, reducing the device size to millimeter dimensions, suitable for implantable applications. The toolkit’s versatility is demonstrated by a redox flow iontophoretic drug delivery prototype at the millimeter scale, featuring two electrodes, four membranes, and four microfluidic channels.
Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial
Authors: Ruan Dan-Yun , Huang Wen-Wen , Li Yongsheng , Zhao Yanqiu , Shi Yehui , Jia Yuming , Cang Shundong , Zhang Wei , Shi Jianhua , Chen Jun , Lin Jie , Liu Yunpeng , Xu Jianming , Ouyang Weiwei , Fang Jian , Zhuang Wu , Liu Caigang , Bu Qing , Li Manxiang , Meng Xiangjiao , Sun Meili , Yang Nong , Dong Xiaorong , Pan Yueyin , Li Xingya , Qu Xiujuan , Zhang Tongmei , Yuan Xianglin , Hu Sheng , Guo Wei , Li Yalun , Li Shengqing , Liu Dongying , Song Feixue , Tan Liping , Yu Yan , Yu Xinmin , Zang Aimin , Sun Chang , Zhang Qian , Zou Kai , Dan Mo , Xu Rui-Hua , Zhao Hongyun
Published: February 2025

HA121-28, a promising multikinase inhibitor, mainly targets rearranged during transfection (RET) fusions and selectively targets vascular endothelial growth factor receptor-2, endothelial growth factor receptor, and fibroblast growth factor receptor 1-3. The safety, pharmacokinetics, and efficacy of HA121-28 were assessed in advanced solid tumors (phase 1, ClinicalTrials.gov NCT03994484) and advanced RET fusion-positive non-small-cell lung cancer (RET-TKI naive NSCLC, phase 2, ClinicalTrials.gov NCT05117658). HA121-28 was administered orally in doses range from 25 to 800 mg under the 21-day on/7-day off scheme for a 28-day cycle in phase 1 trial. The recommended dose identified in phase 1 (450 mg) was administered for patients during phase 2. The primary endpoints were the maximum tolerated dose (MTD) in phase 1 and the objective response rate (ORR) in phase 2. 162 patients were enrolled in phase 1 and 48 in phase 2. A total of 600 mg once daily was set as MTD. Across 100–800 mg, the exposure of HA121-28 increased in a dose-dependent manner. Consistent between both trials, diarrhea, rash, and prolonged QTc interval, were the most reported treatment-emergent adverse events. 40.0% (phase 1) and 62.5% (phase 2) patients experienced grade ≥3 treatment-related adverse events, respectively. The overall ORR was 26.8% and the median progression-free survival (PFS) was 5.5 months among 97 NSCLC patients with advanced RET fusion receiving a dose at ≥450 mg once daily. HA121-28 showed encouraging efficacy in advanced RET fusion NSCLC and its toxicity was tolerable in most patients. Nevertheless, cardiotoxicity is a notable concern that warrants careful attention.
Association between climate related hazards and depression among coastal communities in Indonesia
Authors: Maharani Asri , Sujarwoto Sujarwoto , Susanti Herni , Brooks Helen , Bee Penny
Published: February 2025

Climate change has a profound impact on the mental health and well-being of people all over the world. However, studies on the impacts of climate-driven rising sea levels on mental health remain few. This study aims to examine the risk of depression among people who live in coastal areas susceptible to the natural hazards associated with climate change. We used the Indonesia Basic Health Survey 2018, which included 642,419 adults in Indonesia. Multivariable logistic regression analysis was conducted to examine the relationship between living in a coastal hazard area and depression. We included socio-demographics, health status, and health access information in the analysis to identify the most vulnerable groups. Our findings show that people who live in coastline hazard areas have 1.13 times higher odds to have depression than people who live outside those areas. Individuals living in the coastal hazards areas who were less likely to have autonomous mobility or resources, including young adults, females, those with low socio-economic conditions, and those with pre-existing health conditions, had a higher risk of depression than other groups. Culturally acceptable and effective mental health interventions should thus target these vulnerable populations and settings to effectively reduce climate-related health risks.
Proteomic insights into survival strategies of Escherichia coli in perchlorate-rich Martian brines
Authors: Kloss Lea D. F. , Doellinger Joerg , Gries Anne , Soler Elisa , Lasch Peter , Heinz Jacob
Published: February 2025

Brines, potentially formed by the deliquescence and freezing point depression of highly hygroscopic salts, such as perchlorates (ClO4
−), may allow for the spatial and temporal stability of liquid water on present-day Mars. It is therefore of great interest to explore the microbial habitability of Martian brines, for which our current understanding is, however, still limited. Putative microbes growing in the perchlorate-rich Martian regolith may be harmed due to the induction of various stressors including osmotic, chaotropic, and oxidative stress. We adapted the model organism Escherichia coli to increasing sodium perchlorate concentrations and used a proteomic approach to characterize the adaptive phenotype. Separately, the microbe was adapted to elevated concentrations of sodium chloride and glycerol, which enabled us to distinguish perchlorate-specific adaptation mechanisms from those in response to osmotic, ion and water activity stress. We found that the perchlorate-specific stress response focused on pathways alleviating damage to nucleic acids, presumably caused by increased chaotropic and/or oxidative stress. The significant enrichments that have been found include DNA repair, RNA methylation and de novo inosine monophosphate (IMP) biosynthesis. Our study provides insights into the adaptive mechanisms necessary for microorganisms to survive under perchlorate stress, with implications for understanding the habitability of Martian brines.
Unraveling the Interfacial Homogeneity and Bulk Crystallization for Efficient and Stable Perovskite Solar Cells via Ionic Liquids
Authors: Xu Xiaowei , Li Sibo , Shan Chengwei , Gu Xiaoyu , Zeng Jie , Peng Wenbo , Dai Tingting , Xu Xin , Zeng Xianghui , Zhou Erjun , Xie Chen , Zhang Yong , Qiu Longbin , Xu Baomin , Kyaw Aung Ko Ko
Published: February 2025

Despite advances in the efficiency of inverted perovskite solar cells using self-assembled monolayers (SAMs), challenges persist in both efficiency and stability due to issues at the bottom interface and within...
Halozincate Ionic Liquid Electrolyte Enabled High-Temperature Dendrite-free Zn Metal Batteries
Authors: Yang Mingchen , Zou Xiuyang , Wu Mingzhu , Yu Jiangtao , Ma Xinyu , Hu Yin , Yan Feng
Published: February 2025

Aqueous Zn metal batteries (ZMBs) are receiving increasing attention due to their safety, cost-effectiveness, and scalability. However, aqueous ZMBs suffer from the hydrogen evolution reaction (HER), dendrite growth, and intrinsic...
Detection of cesium in salt-lake brine using laser-induced breakdown spectroscopy combined with convolutional neural network
Authors: Shi Xiangyu , Gong Shuhang , Zeng Qiang , Ye Jinrui , Li Yaju , Lu Junxian , Wu Yifan , Wang Shaowei , Zhao Kou , Liu Xueqi , Zhong Shilei , Liu Hongyan , Zhou Yongquan , Yang Lei , Zhang Shaofeng , Ma Xinwen , Qian Dongbin
Published: February 2025

To meet the application needs for cesium (Cs) extraction from salt-lake brines, the present work explores a laser-induced breakdown spectroscopy (LIBS) method that facilitates sample analysis by breakdown near the...
‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes
Authors: Shepherd Robert A. , Fihn Conrad A. , Tabag Alex J. , McKinnie Shaun M. K. , Sanchez Laura M.
Published: February 2025

In this review we highlight recent advancements in mass spectrometry that have allowed for more efficient, robust, and rigorous enzyme engineering for various applications relating to natural products chemistry.
Computational Exploration of Vinyl Sulfoxonium Ylide Chemistry
Authors: Gopalakrishnan Dinesh Kumar , Vaitla Janakiram , Karmakar Tarak
Published: February 2025

This review comprehensively examines the computational techniques employed to elucidate the reactivity, selectivity, and mechanistic pathways of vinyl sulfoxonium ylide. By delving into a spectrum of reactions ranging from insertion...
Generation of C(sp3)-CAr Bonds in the Synthesis of Triarylmethanes (TRAMs): Comprehensive Progress Since 2009
Authors: Teli Yaqoob  A. , Kant Kamal , Chanu S. Aleena , Aljaar Nayyef , Malakar Chandi Charan
Published: February 2025

Triarylmethanes are useful compounds in material sciences and medicinal chemistry. These moieties are important constituents of dyes and pharmaceuticals. These scaffolds are synthesized either by Friedel-Crafts alkylation of aldehydes and...
Nanoconfined Polymerization: Advantages of Lyotropic Liquid Crystals as Soft Templates
Authors: Tabatabaei Seyed Mostafa , Foudazi Reza
Published: February 2025

Polymerization within nanoconfinement offers a versatile approach to creating nanostructured materials with unique properties and a wide range of applications. Therefore, it is important to understand the nature of polymerization...
Long-range magnetic interaction of native defects in transition metal dichalcogenides
Authors: Gaikwad Prashant Vijay , Hoang T. Thuy , Park Sungjin , Bang Junhyeok
Published: February 2025

Long-range magnetic interaction between native cation antisite defects (MS) can induce ferromagnetism in transition metal dichalcogenides, such as WS2 and MoS2, without any doping of magnetic elements.
Optimization of low-temperature pyrolysis of dioxins in fly ash from municipal solid waste incineration: adding catalysts and inhibitors
Authors: Wen Zhuoyu , Li Weishi , Li Li , Li Xiaoting , Yan Dahai , Liao Yang
Published: February 2025

This study simulates the low-temperature heat treatment of municipal solid waste incineration fly ash (MSWIFA, abbreviated as FA) under industrial conditions and investigates the enhancement of the process by inhibitors...
Green synthesis of ultra-bright Cs3MnBr5 films by CVD method
Authors: Li Shu , Ma Chuanhe , Li Fushuai , Jiang Jinchun , Wang Hailong
Published: February 2025

In this study, we successfully synthesized Cs3MnBr5 films via vapor deposition for the first time using CsBr and MnBr2 raw materials. The optimal deposition temperature is 900°C, achieving a maximum...
Enhancing Magnetic Coupling in MN4-Graphene via Strain Engineering
Authors: Rezaei Mahnaz , Abouie Jahanfar , Nazari Fariba
Published: February 2025

MN4-embedded graphene (MN4-G) layers, incorporating transition metal elements (M), represent a class of experimentally accessible two-dimensional materials with significant potential for stable nanoscale magnetization. In these systems, magnetic exchange interactions...
Comparative Electromagnetic Shielding Performance of Ti₃C₂Tₓ–PVA Composites in Various Structural Forms: Compact Films, Hydrogels, and Aerogels
Authors: Naqvi Shabbir Madad , Hassan Tufail , Iqbal Aamir , Zaman Shakir , Cho Soo Yeong , Hussain Noushad , Kong Xiangmeng , Khalid Zubair , Hao Zhiwang , Koo Chong Min
Published: February 2025

The structural design of lightweight MXene-polymer composites has attracted significant interest for enhancing both electromagnetic interference (EMI) shielding performance and mechanical strength, which are critical for practical applications. However, a...
Brønsted Acid-Catalyzed Synthesis of Sulfinamidines and Sulfinimidate Esters through Electrophilic Fluorination and Substitution
Authors: Li Min , Wang Jingyu , Ou Xiongfei , Yu Jingxun
Published: February 2025

In this work, we present an innovative Brønsted acid-catalyzed approach for the concurrent preparation of sulfinamidines and sulfinimidate esters from sulfenamides under one set of mild and metal-free conditions, employing...
Thermoresponsive Lactate Amide Acrylic Polymers Developed from PLA Bags
Authors: Palà Marc , Ismagilova Alina , Moreno Adrian , Plaza Jorge , Ronda Juan C. , Galià Marina , Vares Lauri , Lligadas Gerard
Published: February 2025

The growing global demand for sustainable products, driven by the depletion of fossil resources and mounting environmental concerns, has amplified interest in transforming lignocellulosic biomass into bio-based solvents, fine chemicals,...
High-modulus supramolecular glassy polymers: a review
Authors: Wang Yin , Cao Zilong , Liu Tong , Wang Lin , Fu Zhongbao , Li Yujuan , Xu Jianhua , Fu Jiajun
Published: February 2025

The concept of recyclability or repairability provides a new approach for extending the service life of glassy polymers and addressing environmental pollution issues.
Palladium-based coordination cages as dynamic crosslinks in acrylamide hydrogels
Authors: Hu Chaolei , Chen Damien W. , Sudan Sylvain , Severin Kay
Published: February 2025

Hydrogels with PdnL2n-type junctions can be obtained by photoinitiated copolymerization of palladium cages with acrylamide monomers in water. The dynamic nature of the cage crosslinks allows for an anion-induced switch in network topology.
Biocompatible Fiber-Based Flexible Magneto-Mechano-Electric Generators Enhanced by UV and IR Treatments for Sustainable IoT Sensors
Authors: Ram Nayak , Vaduganathan Karthik , Venkateswarlu Annapureddy
Published: February 2025

The Internet of Things (IoT) demands sustainable energy sources for power sensors and communication components. This study presents a magnetoelectric (ME) coupled magneto-mechano-electric (MME) energy harvester designed to capture energy...
Biochemical Society support in action: experiences from our community
Authors: Ollett Lucy
Published: February 2025

Throughout the year, the Biochemical Society offers a programme of grants for all career stages, supporting research, attendance at scientific conferences, and the sponsorship of events. In 2024, we awarded over £400,000 towards international collaboration, knowledge exchange, outreach projects and summer vacation studentships. In this article, we are delighted to share a few insights from our community that highlight the variety of projects and opportunities made possible by our funding.

For more information about our funding opportunities and the application process, please visit our website.
Qualitative Analysis of Therapist Documentation of Assessments of Orally Feeding Infants Who Require Noninvasive Respiratory Support
Authors: Barnes Carolyn , Simpson Kit N. , Wilmskoetter Janina , McGhee Heather , Nichols Keeley , Bonilha Heather S.
Published: February 2025

Purpose:

This is a qualitative analysis of speech-language pathology and occupational therapy documentation of bedside assessments of infants orally feeding on noninvasive respiratory support (NRS).

Method:

Data were extracted from speech-language pathology and occupational therapy electronic health record documentation of bedside feeding/swallowing assessment and treatment of infants on NRS. These data included the rate of documentation of objective metrics, as well as themes in feeding safety, quality, and therapeutic interventions.

Results:

Notes from 37 speech-language pathologist and occupational therapist bedside visits were included. Data on the amount of NRS during oral feeding were inconsistently documented, but reported flow rate ranged from 0.2 to 5.0 l per minute. Approximately 57% of notes indicated some type of overt feeding problem. Objective data were inconsistently documented, but common metrics included signs of possible aspiration (cough in 16.2% and congestion in 13.5% of notes), liquid viscosity (43.2% of notes), feeding modality (94.6% of notes), volume offered (56.8% of notes) and consumed (81.1% of notes), and feeding time (56.8% of notes). Documentation themes include assessment of both safety and quality, implied stability and success rather than explicit documentation of such, infrequent instrumental assessment referral, differences between assessment versus follow-up treatment notes, differences in structured/templated notes versus unstructured narratives, and missing data.

Conclusions:

Missing data limited our ability to draw conclusions regarding safety and quality of oral feeding during NRS use. We make recommendations for documentation, including prioritizing objective data, clarifying clinical interpretations, patient responses to interventions trialed, and use of structured narratives and flowcharting.
Motion vehicle detection for traffic video streams
Authors: Song Jianhao , Ding Hua , Liu Lai , Chen Juntao
Published: February 2025

This research offers an enhanced version of the YOLOv5s+MobileNetV3+BiFPN method to address a number of issues in moving vehicle recognition in traffic video streams, including lightweight network model, motion blur, scene delay etc. By substituting YOLOv5s BackBone with the lightweight MobileNetV3 backbone network and employing a parameter‐free attention mechanism, the network model's parameters are reduced. To improve the ability of features to learn, use SimAM instead of SENet structure; Integrating the BiFPN network will increase the computing cost while improving the detection accuracy; Utilize the K‐means++ method to improve the anchor frame choice and boost the detection performance for targets of various scales; In addition, the dataset is arbitrarily disregarded to address the issue of extreme information redundancy. Results are obtained by applying the enhanced algorithm to the processed video detection dataset. The experimental findings demonstrate that this method, when compared to the original YOLOv5s algorithm, has a faster detection speed and a higher detection accuracy in the detection of vehicle targets in traffic video streams. The mAP@0.5:0.95 improved by 11.23%, and the FPS increased from 15.87 to 47.62.
Substellar candidates at the earliest stages: The SUCANES database
Authors: Pérez-García A. M. , Huélamo N. , García López A. , Pérez-Martínez R. , Verdugo E. , Palau A. , de Gregorio-Monsalvo I. , Morata O. , Barrado D. , Morales-Calderon M. , Mas-Hesse M. , Bayo A. , Maucó K. , Bouy H.
Published: February 2025

Context. Brown dwarfs are the bridge between low-mass stars and giant planets. One way of shedding light on their dominant formation mechanism is to study them at the earliest stages of their evolution, when they are deeply embedded in their parental clouds. Several works have identified pre- and proto-brown dwarf candidates using different observational approaches.

Aims. The aim of this work is to create a database of all the objects classified as very young substellar candidates in the literature in order to study them homogeneously.

Methods. We gathered all the information about very young substellar candidates available in the literature until 2020. We retrieved their published photometry from the optical to the centimetre regime, and we wrote our own codes to derive their bolometric temperatures and luminosities, and their internal luminosities. We also populated the database with other parameters extracted from the literature, such as the envelope masses, their detection in some molecular species, and the presence of outflows.

Results. The result of our search is the SUbstellar CANdidates at the Earliest Stages (SUCANES) database, containing 174 objects classified as potential very young substellar candidates in the literature. We present an analysis of the main properties of the retrieved objects. Since we updated the distances to several star forming regions, we were able to reject some candidates based on their internal luminosities. We also discuss the derived physical parameters and envelope masses for the best substellar candidates isolated in SUCANES. As an example of a scientific exploitation of this database, we present a feasibility study for the detection of radio jets with upcoming facilities: the next generation Very Large Array and the Square Kilometer Array interferometers. The SUCANES database is accessible through a graphical user interface, and it is open to any potential user.
Salmonellosis: Threats to the economy and avian health
Authors: Faizrakhmanova Gulina , Galiullin Albert , Koroleva Lidia , Spiridonov Gennady , Makhmutov Aidar
Published: February 2025

The article gives a modern classification of salmonellosis. Their morphological and biological properties are detailed. The general characteristic of the disease caused by salmonellosis of birds is presented in full. Briefly, but with the designation of all major milestones, it reflected the history of the study of salmonellosis. Reasons and factors contributing to the pathology are revealed. Localization of lesions depending on the routes of infection is presented in sufficient detail. Interesting materials on laboratory diagnostics of salmonellosis of birds are presented. Materials on the general principles of treatment of birds are presented, and the issues of specific prophylaxis and prospects for combating it are highlighted. In order to ensure epizootic well-being, the article gives recommendations on general preventive measures: observance of hygiene of keeping birds and timely protective vaccinations, which will prevent the occurrence of the disease. The general preventive measures include proper feeding. An important aspect is also personal and industrial hygiene of service personnel, as a person can be a carrier and source of spread of salmonellosis. The presented material contains the results of studies of a number of domestic and foreign epidemiologists, epizootologists and bacteriologists, as well as the results of the authors’ own research.
Influence of natural biostimulants on growth and quality of cattle meat
Authors: Ashurov Nurali , Yusupov Abdulaziz , Primkulov Bekzod , Kurbanov Abdimalik , Grankina Natalia A. , Bogus Aslan Yu.
Published: February 2025

The presented work is devoted to the study of the influence of natural biostimulants on the productivity of cattle grown for meat. The aim of the study was to determine the effectiveness of biotechnological methods to increase the growth rate of animals and improve the quality of meat raw material. In the course of the experiment, control and experimental groups of animals differing in feeding ration were formed. The experimental group received a standard diet supplemented with natural biostimulants. The results of the study showed that the use of biostimulants leads to an increase in average daily live weight gain by 18%, as well as to a reduction in the fattening period by 20 days. In addition, the experimental group showed an improvement in meat quality indicators such as colour, pH, fat and protein content. The obtained data indicate the promising use of natural biostimulants to improve the efficiency of animal husbandry and production of high quality beef.
Biogas as a solution to the problem of waste utilisation in agriculture
Authors: Sevryugina Nadezhda S. , Dragulenko Vladislav V. , Sukhanov Dmitry S. , Ukraintsev Maxim M. , Korchagin Pavel T.
Published: February 2025

This article is devoted to the study of the potential of biogas technologies on the example of the Republic of Karelia, with a focus on the processing of agricultural waste. The authors consider the problem of utilisation of organic waste, which is traditionally stored or incinerated, and propose an alternative solution - anaerobic digestion for the production of biogas, energy and fertilizers. The study includes analyses of statistical data on the amount and composition of waste, as well as a study of global experience in this area. The significant potential of Karelia for biogas production, mainly from manure and crop residues, has been identified. It is calculated that 17.2 million cubic metres of biogas can be produced from 248 thousand tonnes of manure, potentially producing about 31.8 million kWh of electricity. The study highlights that the biogas yield depends on the type of feedstock and that biogas fertilisers increase crop yields. Successful examples of biogas technology implementation in other regions and countries emphasise the promising potential of this area. The work confirms the significant potential of biogas technologies in Karelia, but also points out the need to overcome technical and economic barriers.
Optimisation of anaerobic digestion of agricultural waste by simulation modelling
Authors: Matasova I.Yu. , Masenko Aleksey V. , Grigoryan David R. , Tokareva Anna N. , Demchenko Maria S.
Published: February 2025

The article deals with the problem of agricultural waste processing, focusing on anaerobic digestion for biogas and fertiliser production. The study is devoted to the optimisation of this process on the example of poultry manure, using a simulation-statistical approach. The developed model of the biotechnological system includes waste separation into fractions, pre-digestion, methane digestion and anaerobic filtration. Substrate loading dose and substrate moisture content were found to have the greatest influence on energy release. Experiments showed that an increase in loading dose leads to an increase in biogas yield. Modelling allowed us to obtain an energy release equation that takes into account humidity, loading dose and digestion temperature. The maximum energy yield is achieved at a certain combination of these parameters. The study also showed that the use of the proposed biotechnological system can contribute to meeting part of the region’s heat energy needs through the production of biogas from waste. Measures to optimise waste collection and processing, including the formation of databases and simulation modelling, have been proposed.
Granulated goat milk sublimate and the experimental setup for its production
Authors: Yerofeyeva Natalya , Shakhov Artem , Glotova Irina , Shakhov Sergey , Blinnikov Kirill
Published: February 2025

Prospects for the use of goat’s milk (GM) as a food system are associated with the intensification of biological processes of its reproduction, as well as technologies for its processing and preservation. The purpose of the study is to substantiate the method of preserving goat’s milk using an experimental spray freeze drying unit. The object of the study was the milk of goats of the Zaanen breed. The differential scanning calorimetry (DSC) method established a difference in the amount of binding energy of water fractions with dry matter in GM, which causes differences in energy consumption for GM dehydration at different stages of the drying process. The results were used to develop a drying method that makes it possible to carry out the processes of dehydration of goat lactation products under the gentlest conditions close to thermal conditions when producing these colloidal systems in the animal body. An experimental spray vacuum sublimation plant was used to produce granulated GM. Combining the structural elements of spray and freeze dryers allows balancing between the structural complexity of the device, its energy efficiency and the quality of the product.
Disinfection of beekeeping objects with oxygen-containing preparations for bee aspergillosis
Authors: Gruznov Dmitry V. , Gruznova Olga A. , Sokhlikov Alexey B. , Chesnokova Irina P.
Published: February 2025

Aspergillosis of bees is an infectious disease of bee brood and adult bees caused by fungi of the Aspergillus genus. These fungi live and are reproduced in soil, feeding on plant material, including the stamens and nectary of flowers. The causative agents are brought into hives by bees carrying nectar and pollen. Once inside, they grow on honeycomb, bee bread, larvae, pupae, and adult bees under favorable conditions. Aspergillosis is a zooanthroponosis, causing significant economic damage to beekeeping and potentially posing a risk to consumers of bee-derived products. Therefore, important tasks are the selection of preparations that meet the requirements of the industry and the development of effective regimens and applications. This paper presents the results of laboratory and apiary trials of oxygen-containing preparations for the disinfection of bee-keeping facilities (hives, frames, equipment) in cases of aspergillosis. Based on the data obtained, effective regimes of their use are recommended.
Organization of veterinary services for industrial duck farming: Problems and solutions
Authors: Vasiliev Mihail N. , Gainutdinova Karina V. , Ravilov Rustam Kh. , Vasilieva Anastasia I.
Published: February 2025

Proper organization of veterinary services is one of the key elements of economic efficiency of duck farming. It has been established that there are a number of problems in the organization of veterinary services for duck breeding in the country that require scientific analysis. This is insufficient elaboration of the issues of normative-legal regulation of veterinary requirements for duck keeping. However, the state plans to solve this issue in 2025 by adopting new Veterinary Rules, but the draft of this document does not contain any specifics of keeping waterfowl (ducks and geese), taking into account their physiological need for water. The second problem is the lack of unified approaches in planning and organization of veterinary preventive measures against contagious and other diseases of ducks. The authors recommended scientifically based technological cards of veterinary treatment of ducks, which will contribute to the organization of an effective system to control the risks of occurrence and spread of contagious and other diseases of ducks. The third problem is the lack of the scientifically based planning of staffing veterinary specialists for duck breeding farms (enterprises). Here the authors recommend 42 developed norms of time for carrying out veterinary and preventive measures, works performed by veterinary specialists in hatcheries, and registration of veterinary documentation. Also 5 norms of time for laboratory tests for the most significant for industrial duck farming infections have been developed. A systematic approach to the organization of veterinary services for industrial duck farming on the basis of the developed recommendations will ensure stable epizootic well-being of the industry, which will positively affect its economic efficiency.
Development of probiotic feed based on homogenised potato pulp
Authors: Borotov Atkham , Narzullaev Olim , Yakubov Lazizkhon , Rajabova Matluba , Karshieva Bogdagul
Published: February 2025

This paper presents a study aimed at developing a probiotic feed preparation based on a secondary product of the food industry - homogenised potato mass (HPM). The possibility of using HPC as a substrate for cultivation of probiotic bacteria Bacillus subtilis and Lactobacillus plantarum was studied. It was experimentally shown that GCM provides effective growth and multiplication of these bacteria, and lyophilisation allows to preserve their viability for a long time. The obtained preparation demonstrated pronounced antibiotic activity against a number of pathogenic microorganisms. This allows us to conclude that HCM is a promising raw material for the production of cost-effective and efficient probiotic preparations, which contributes to the development of sustainable animal husbandry and reduces dependence on antibiotics. The results confirm the possibility of efficient utilisation of secondary raw materials for the production of probiotics and indicate the importance of further research in this area.
Enzyme complex influence on physiological properties of alcoholic yeast during cultivation
Authors: Yakovlev Alexey , Agafonov Gennady , Yakovleva Svetlana , Romanyuk Tatyana , Zueva Natalia , Chusova Alla , Kovaleva Tatyana
Published: February 2025

The effect of enzyme preparations of neutral Prolife BS Liquid protease and Kingfos phytase on the physiological and technological properties of Saccharomyces cerevisiae yeast of race XII in alcohol production was studied. The maximum accumulation of yeast cells occurs when the enzyme preparation of neutral Prolive BS Liquid protease was added to the wort at a dosage of 0.2 units PS/g of starch and Kingfos phytase with a dosage of 0.5 units FS/g of starch. The content of yeast cells in ripe yeast reached 170 million cells/cm3 after 16-18 hours of cultivation. Such yeast has a high fermentation activity.
Resource potential of the agro-industrial complex of Siberia and its role in ensuring food security of Russia
Authors: Tarasenko Daria S. , Rozhkov Evgeniy A. , Asaturyan Andrey V. , Lepekhina Yu.A.
Published: February 2025

The paper is devoted to the analysis of the resource potential of the agro-industrial complex of the Siberian Federal District of Russia and its impact on the food security of the country. A comprehensive analysis, including the collection of statistical data and the assessment of land, labour, financial and innovation resources has been carried out. Significant differences in resource endowment between the regions of the SFD have been revealed. Land resources vary from 0.3 million hectares in Tyva to 4.5 million hectares in Altai Krai, while the quality of soils and the share of arable land also differ significantly. Labour resources are characterised by varying numbers of employees, skill levels and wages, while financial resources are characterised by investment volumes and access to credit. Innovation potential was assessed by the level of introduction of new technologies and agronomic practices. The results showed that Altai Krai and Novosibirsk Oblast stand out with more favourable conditions and high performance in the agro-industrial complex, while the Republic of Tyva and some other regions have low resource endowment and low production efficiency. Overall, the study emphasises the need for a differentiated approach to state support for agro-industrial complex in the SFD to improve food security.
Reduction of microbiological contamination of poultry feed by electrophysical method
Authors: Borotov Atkham , Allanazarov Akmal , Baratov Dilshod , Murodov Xamidulla , Isayev Oybek , Tsyganko E.N.
Published: February 2025

The problem of microbial contamination of feed negatively affects the efficiency and safety of livestock production. In this study, the level of microbial contamination of various feeds for poultry was evaluated and the effectiveness of the electrophysical method of its reduction was studied. The objects of the study were compound feed for laying hens, plant-based feed mix and spring wheat grain. The selected samples were examined for the presence of total microbial count (TMC), total fungal count (TFC), as well as Salmonella and Escherichia coli. The experimental samples were microwave treated on a specialised processing line at 60 kW power, 915 MHz frequency and 90 seconds exposure. Analyses showed that the initial microbial contamination level varied with feed type, with no Salmonella or E. coli detected in the control samples. Microwave treatment resulted in a significant reduction in WMB and WBC counts in all feed types tested. The obtained results confirm the effectiveness of microwave EMF application to reduce microbial contamination of feeds.
A study of the impact of the resource thermal power plants with ‘de-industrialised design’ on the NIMBY effect
Authors: Li Qiuyan , Tian Ruifeng
Published: February 2025

The construction of the resource thermal power plant has negative impacts on the surrounding residents and it causes the NIMBY effect. The “de-industrialized” design can alleviate the NIMBY effect of the power plant to a certain extent. This paper quantifies the degree of impact of resource thermal power plant with“de-industrialization design” to the NIMBY effect from the perspective of housing prices. It takes Shenzhen Eastern Energy Eco-Park as example to analyze the changes in price of the Second-hand Properties around Power Plants by Hedonic-Price Models and Kriging Interpolations. The results of the study show that the resource thermal power plants with ‘de-industrialised design’ can effectively mitigate the NIMBY effect. Within a certain range, the magnitude of the impact decreases with distance. So it is suggested that the construction of the resource thermal power plant should be adapted to the local conditions, and the application of the “de-industrialization” design should be used to improve the acceptance of the residents of the plan to create a good human environment.
Study on influence factors of mixing uniformity for dredged spoil utilized as a resource by PFM with static mixer
Authors: Hu Junlong , Lu Hesheng , Xie Yao , Li Jinxiang , Wang Deyong
Published: February 2025

The static mixer is a non-moving structure used for mixing fluid medium in the pipeline, and structural parameters are important factors affecting the mixing effect. Due to the unclear influence of structural parameters on mixing uniformity for dredged mud and curing agent mixed by static mixers, the motion mode of fluid medium and the influence of unit number and deflection angle between adjacent units on the mixing uniformity are studied by multiphase flow simulation. The results show that the fluid in the cross-plate panel static mixer exhibits an alternating spiral forward motion mode, and the coefficient of uniformity of dredged mud and curing agent can be reduced by 26% - 98% after mixing. Under the conditions that the deflection angle is less than or equal to 60°, the mixing uniformity of the cross-plate panel static mixer with 2 pieces is better than that with 4 pieces. The mixing uniformity increases with the increase of the number of units. There is an optimal deflection angle between adjacent units, and too small or too large deflection angle will lead to the decrease of mixing uniformity. The study will help to optimize the structure of the existing pneumatic flow mixing device and improve the mixing effect.
Defect Signal Identification in Concrete-Filled Steel Tubular Columns Based on Wavelet Analysis
Authors: Wang Hang , Zhang Jianwen , Zha Bo , Shao Zhiwei
Published: February 2025

Based on the principle of acoustic energy distribution at a single flat interface under vertical ultrasonic incidence, this study derives the reflection and transmission coefficients for both healthy bonding interfaces and debonded interfaces in concrete-filled steel tubular (CFST) columns. The calculation results indicate that when debonding defects occur in CFST, the signal amplitude received by the transducer on the same side increases significantly. By applying wavelet denoising and wavelet packet energy calculation methods to the experimental study of debonding damage identification at CFST interfaces, the area and extent of debonding defects can be accurately predicted.
Ultrasonic Damage Detection of Composite Panels Based on Wavelet Analysis
Authors: Juan Qian , Xiaoliang Huang , Bo Zha , Fuxiang Ye , Zhiwei Shao
Published: February 2025

The common types of damage in sandwich panels during normal use include: core seam damage, delamination caused by adhesive aging due to alternating hot and cold temperatures, and indentation damage caused by impact. Such damages can weaken the load-bearing capacity of sandwich panels. If not identified promptly, they may result in accidents and potential injuries. In this study, a non-metallic ultrasonic testing device was used to detect various types of damage in the sandwich panels, and wavelet analysis theory was applied to process the experimental data.
Energy-Saving Glazing Solutions: Design and Evaluation of Polarization-Based Mechanical Dimming Windows
Authors: Li Junfei , Luo Qian
Published: February 2025

Modern architecture increasingly integrates amorphous, inorganic, non-metallic, and transparent glass in the construction of high-rise buildings, fueled by the proliferation of social technology. Ordinary glass doesn't allow for subjective adjustment of its light transmission intensity and direction angle. Direct sunlight at noon, shining through an ordinary window, increases eye fatigue and visual loss due to its high intensity, resulting in adverse reactions like dry eyes and tears. To mitigate the negative effects of unsuitable light on people's lives, an adjustable light transmission glass window with directional angles is necessary for societal use. This paper uses a numerical simulation to investigate the correlation between the angle of polarization and the luminous flux of polarized glass windows, providing valuable insights for designing light transmission structures, bridging the knowledge gap on polarization principles in glass windows, and offering significant theoretical and practical implications for glass window manufacturers.
Integrating Building Information Modeling (BIM) with Ecological Engineering for Sustainable Civil Construction
Authors: Zhang Xu , Zhou Qunyou , Zhang Huiying , Zhu Lin , Pei Shuhan
Published: February 2025

With the global emphasis on sustainable development, the construction industry has increasingly adopted eco-friendly practices, particularly through the integration of ecological engineering and Building Information Modeling (BIM) technology. Since the late 1980s, BIM has become a crucial tool in the design, planning, and construction of buildings, enabling more efficient resource management and environmental impact assessment. BIM allows for the creation of detailed digital models that simulate various environmental factors, including energy use, water consumption, material selection, and waste management. Comparative analysis demonstrates that BIM-integrated projects reduce energy consumption by 15%-20% compared to conventional methods. Moreover, BIM's ability to simulate environmental impacts at early design stages significantly minimizes resource waste and project costs. By integrating environmental engineering principles, BIM supports the assessment of the ecological impacts of different materials and construction methods, ensuring that sustainability goals are met from the early stages of design through to demolition. This combined approach not only optimizes resource usage but also reduces carbon emissions and promotes the use of renewable materials, contributing to a more sustainable built environment. Through tools like Life Cycle Assessment (LCA), BIM helps stakeholders make informed decisions that minimize environmental harm throughout the entire lifecycle of a building. In summary, the integration of BIM with ecological engineering enhances the sustainability of construction projects, supporting both environmental and socio-economic benefits, and driving the industry towards a more sustainable future.
Research and Analysis on Carbon Emissions of Substation Construction Projects Based on the Whole Construction Cycle
Authors: Li Qian , Liu Zhuo , Zhang Shuai , Ma Lixing
Published: February 2025

Under the “dual carbon” target of China, research on the carbon emissions generated during the construction of substations as intermediate hubs for power transmission is also very important. This article calculates and studies the carbon emissions generated by various parts of the construction of substations throughout the entire construction cycle, identifies the main projects with a high proportion of carbon emissions in substations, and explores solutions to reduce carbon emissions based on the characteristics of carbon emissions in different projects.
Product-semantics based form design of active wearable upper-limb exoskeletons
Authors: Huang Jiawei , Wu Hao , Yu Zhiyuan
Published: February 2025

With the development of wearable exoskeletons, people's demand for wearable exoskeletons is no longer limited to functionality alone. The aesthetics and symbolic meanings of wearable exoskeletons have also become a focus of attention. This paper aims to propose a method for designing the form of active wearable upper-limb exoskeletons based on product semantics, in order to enhance their form design to meet workshop scenarios and satisfy the physical and mental needs of users. Firstly, it analyzes product symbols and uncovers the appearance semantics, function semantics, symbolic semantics, and market semantics of wearable exoskeletons based on the product semantics. Then, the design process for the form design of active wearable upper-limb exoskeletons based on product semantics is proposed. Finally, design verification is implemented through design proposals of active wearable upper-limb exoskeletons used in logistics handling, fully considering the intrinsic connection between exoskeletons and their product semantics without interfering with the key technical structure of the exoskeleton and effectively integrating refined product semantic symbols into design practice. This can improve the functional utility of exoskeletons, enhance user experience, endow them with rich sociocultural and emotional connotations, and increase market competitiveness.
Vitamin D in Orthopädie und Unfallchirurgie
Authors: Karger Stefan , Roth Andreas
Published: February 2025

Ziel der vorliegenden Arbeit ist es, das Verständnis der Physiologie, des Stoffwechsels und der biologischen Funktionen von Vitamin D zu vertiefen sowie Hinweise zur Identifizierung von Risikopatienten und schließlich zur Behandlung eines Vitamin-D-Mangels zu geben. Die Ausführungen stützen sich im Wesentlichen auf einen Artikel von Holick aus dem Jahr 2024 1 sowie die von Holick et al. 2011 und von Demay et al. 2024 publizierten Leitlinien der Endocrine Society 2, 3, wobei die jüngste Leitlinie im Gegensatz zu 2011 auf eine Risikobewertung von Vitamin-D-assoziierten Erkrankungen bei Individuen mit bisher nicht etablierten Indikationen für eine Vitamin-D-Supplementation bzw. -Messung abzielt.
Fracture Liaison Service
Authors: Scholz Roger
Published: February 2025

Die Osteoporose ist eine sehr häufige Erkrankung, die nach klinisch längerfristig stummem Verlauf zu Fragilitätsfrakturen mit weitreichenden Folgen für den Patienten führt. Nach eingetretener Indexfaktur ist die Refrakturrate auch im kurzfristigen Verlauf bei unbehandelter Grunderkrankung hoch. Morbidität und Mortalität steigen, Schmerzen, Funktionsbeeinträchtigungen und nicht selten Pflegebedürftigkeit belasten den Betroffenen und der hohen Behandlungs- und Pflegekosten wegen auch die Gesellschaft erheblich. Aus diesen Gründen kommt der Sekundär- und Tertiärprävention nach stattgehabter Fraktur eine hohe Bedeutung zu. Ein strukturiertes Versorgungskonzept zur Identifizierung, Diagnostik und Therapieeinleitung sowie Überwachung ist im Rahmen des Fracture Liaison Service (FLS) zu fordern. In zahlreichen internationalen Studien konnte die Effektivität des FLS sowohl individuell für den Patienten als auch hinsichtlich der Kosteneffizienz wissenschaftlich belegt werden. Unterschiedliche FLS-Typen sind vorhanden, wobei nachweisbar war, dass der höhere Aufwand durch einen FLS-Koordinator zu einem signifikant besseren Ergebnis führt und dieser daher als integraler Bestandteil des Netzwerkes zu fordern ist.