bluuebunny/crossref_metadata_2025 huggingface dataset:
Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells
Authors: Tabata Sho , Yamamoto Masatatsu , Goto Hisatsugu , Hirayama Akiyoshi , Ohishi Maki , Kuramoto Takuya , Mitsuhashi Atsushi , Ikeda Ryuji , Haraguchi Misako , Kawahara Kohichi , Shinsato Yoshinari , Minami Kentaro , Saijo Atsuro , Toyoda Yuko , Hanibuchi Masaki , Nishioka Yasuhiko , Sone Saburo , Esumi Hiroyasu , Tomita Masaru , Soga Tomoyoshi , Furukawa Tatsuhiko , Akiyama Shin-ichi
Published: April 2018

Thymidine phosphorylase (TP) is a rate-limiting enzyme in the thymidine catabolic pathway. TP is identical to platelet-derived endothelial cell growth factor and contributes to tumour angiogenesis. TP induces the generation of reactive oxygen species (ROS) and enhances the expression of oxidative stress-responsive genes, such as interleukin (IL)-8. However, the mechanism underlying ROS induction by TP remains unclear. In the present study, we demonstrated that TP promotes NADPH oxidase-derived ROS signalling in cancer cells. NADPH oxidase inhibition using apocynin or small interfering RNAs (siRNAs) abrogated the induction of IL-8 and ROS in TP-expressing cancer cells. Meanwhile, thymidine catabolism induced by TP increased the levels of NADPH and intermediates of the pentose phosphate pathway (PPP). Both siRNA knockdown of glucose 6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme in PPP, and a G6PD inhibitor, dihydroepiandrosterone, reduced TP-induced ROS production. siRNA downregulation of 2-deoxy-D-ribose 5-phosphate (DR5P) aldolase, which is needed for DR5P to enter glycolysis, also suppressed the induction of NADPH and IL-8 in TP-expressing cells. These results suggested that TP-mediated thymidine catabolism increases the intracellular NADPH level via the PPP, which enhances the production of ROS by NADPH oxidase and activates its downstream signalling.
Self-assembly facilitated and visible light-driven generation of carbon dots
Authors: Huang Tian , Wu Tongyue , Zhu Zhiyang , Zhao Li , Ci Haina , Gao Xuedong , Liu Kaerdun , Zhao Junfang , Huang Jianbin , Yan Yun
Published: April 2018

Molecular self-assembly may facilitate visible light generation of carbon dots.
Electrochemical performance enhancement of graphite negative electrode by nano-metallic-oxides
Authors: Wu Yan , Wang Li-Ying , Li Yi-Fan , Zhao Zhen-Yang , Yin Long-Wei , Wang Hai-Feng , Li Hui , Bai Yu-Jun
Published: April 2018

Severe mechanical strain and rapid capacity decay during Li+insertion/extraction processes restrict the potential applications of copper oxides as lithium-ion battery anode materials and modified electrode materials.
Electrocatalytic oxidation of ethanol at Pd, Pt, Pd/Pt and Pt/Pd nano particles supported on poly 1,8-diaminonaphthalene film in alkaline medium
Authors: Hassan K. M. , Hathoot A. A. , Maher R. , Abdel Azzem M.
Published: April 2018

An ethanol oxidation reaction (EOR) in alkaline medium was carried out at palladium (Pd) or platinum (Pt) nanoparticles/poly 1,8-diaminonaphthalene (p1,8-DAN) composite catalyst electrodes.
A robust multifunctional ligand-controlled palladium-catalyzed carbonylation reaction in water
Authors: Gao Pei-Sen , Zhang Kan , Yang Ming-Ming , Xu Shan , Sun Hua-Ming , Zhang Jin-Lei , Gao Zi-Wei , Zhang Wei-Qiang , Xu Li-Wen
Published: April 2018

A novel and robust PEG-modulated s-triazine-based multifunctional and hydrophilic Schiff base/N,P-ligand L9 was employed in the Pd-catalyzed Heck-type carbonylative coupling reactions, yielding chalcone derivatives in good yields.
Photooxidation of oxazolidine molecular switches: uncovering an intramolecular ionization facilitated cyclization process
Authors: Chen Qiaonan , Sheng Lan , Du Jiahui , Xi Guan , Zhang Sean Xiao-An
Published: April 2018

Photooxidation of oxazolidine molecular switches through media-induced intramolecular ionization forming a flexible donating group facilitated cyclization with1O2as the oxidant.
Selective aqueous acetylation controls the photoanomerization of α-cytidine-5′-phosphate
Authors: Fernández-García Christian , Grefenstette Natalie M. , Powner Matthew W.
Published: April 2018

α-Cytidine-5′-phosphate acetylation enhances the photoanomerization to β-ribonucleotide-5′-phosphates 4-fold by blocking oxazolidinone formation and C2′-epimerization.
A novel strategy to evaluate the degradation of quantum dots: identification and quantification of CdTe quantum dots and corresponding ionic species by CZE-ICP-MS
Authors: Meng Peijun , Xiong Yamin , Wu Yingting , Hu Yue , Wang Hui , Pang Yuanfeng , Jiang Shuqing , Han Sihai , Huang Peili
Published: April 2018

The development and application of a CZE-ICP-MS method for the identification and quantification of CdTe QDs and corresponding ionic species in complex matrices are presented.
Effect of iron doping on protein molecular conductance
Authors: Lebedev Nikolai , Griva Igor , Blom Anders , Tender Leonard M.
Published: April 2018

This study analyzes the role of Fe in electron transfer through non-heme iron-containing proteins.
A new anthraquinoid ligand for the iron-catalyzed hydrosilylation of carbonyl compounds at room temperature: new insights and kinetics
Authors: Raya-Barón Álvaro , Galdeano-Ruano Carmen P. , Oña-Burgos Pascual , Rodríguez-Diéguez Antonio , Langer Robert , López-Ruiz Rosalía , Romero-González Roberto , Kuzu Istemi , Fernández Ignacio
Published: April 2018

The synthesis and characterization of a highly active Fe(ii) catalyst for the hydrosilylation of aldehydes and ketones have been described.
Catalyst-free tandem halogenation/semipinacol rearrangement of allyl alcohols with sodium halide in water
Authors: Zeng Zhixuan , Xun Xudong , Huang Liwu , Xu Jiecheng , Zhu Gongming , Li Guofeng , Sun Wangsheng , Hong Liang , Wang Rui
Published: April 2018

A convenient procedure for the synthesis of β-haloketones via the tandem halogenation/semipinacol rearrangement of allyl alcohols with NaX.
Facile and eco-friendly extraction of cellulose nanocrystalsviaelectron beam irradiation followed by high-pressure homogenization
Authors: Lee Minwoo , Heo Min Haeng , Lee Hyunho , Lee Hwi-Hui , Jeong Haemin , Kim Young-Wun , Shin Jihoon
Published: April 2018

Cellulose nanocrystals were preparedviashort-time pretreatment by electron-beam irradiation in the solid state and disintegration using high pressure homogenization.
Facile synthesis of functionalized urea, imidazolium salt, azide, and triazole from a 2-amino-5,7-dimethyl-1,8-naphthyridine scaffold and their utilization in fluoride ion sensing
Authors: Chahal Mandeep K. , Dar Tawseef Ahmad , Sankar Muniappan
Published: April 2018

We report an elegant and modest synthetic route for the synthesis of four new 1,8-naphthyridine-based receptors (1a, 1b, 2, 3 and 4). Among them, 1a and 2 exhibit selective recognition of F− ions.
Chemical tools for the generation and detection of singlet oxygen
Authors: You Youngmin
Published: April 2018

The recent advances and prospects of the development of molecular tools capable of generation and detection of singlet oxygen are disclosed.
Electronic effect of substituents on anilines favors 1,4-addition totrans-β-nitrostyrenes: access toN-substituted 3-arylindoles and 3-arylindoles
Authors: Gattu Radhakrishna , Bhattacharjee Suchandra , Mahato Karuna , Khan Abu T.
Published: April 2018

A simple and an efficient method for the regioselective synthesis ofN-alkyl/aryl/H 3-arylindole derivatives fromN-substituted anilines andtrans-β-nitrostyrenes has been described using 10 mol% of bismuth(iii) triflate as a catalyst in acetonitrile at 80 °C.
Regio- and stereospecific Friedel–Crafts alkylation of indoles with spiro-epoxyoxindoles
Authors: Li Guofeng , Bao Guangjun , Zhu Gongming , Li Yiping , Huang Liwu , Sun Wangsheng , Hong Liang , Wang Rui
Published: April 2018

A highly efficient strategy for the regio- and stereospecific Friedel–Crafts alkylation of indoles with spiro-epoxyoxindoles has been developed in the mixed solvents of HFIP/H2O (1 : 9) without the use of catalysts.
Iridium-catalysed conjugated alkynylation of α,β-unsaturated amide through alkene isomerization
Authors: Chen Yun , Wang Zi-Xuan , Li Qian , Xu Li-Jin , Li Bi-Jie
Published: April 2018

We have developed an iridium-catalysed conjugated alkynylation of α,β-unsaturated amide.
Palladium-catalyzed asymmetric dearomative alkenylation of indoles through a reductive-Heck reaction
Authors: Liang Ren-Xiao , Yang Run-Ze , Liu Ren-Rong , Jia Yi-Xia
Published: April 2018

A highly enantioselective intramolecular dearomatizing olefination of indoles has been developed through a Pd-catalyzed reductive Heck reaction.
Novel SA@Ca2+/RCSPs core–shell structure nanofibers by electrospinning for wound dressings
Authors: Li Rui , Cheng Zhiqiang , Wen Ruicheng , Zhao Xiaodong , Yu Xiaobin , Sun Lin , Zhang Yingying , Han Zhiyuan , Yuan Yafeng , Kang Lijuan
Published: April 2018

Core–shell nanofiber membranes by coaxial electrospinning process that became gel after absorbing blood were used for wound repair.
Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films
Authors: Hüsler Amanda , Haas Simon , Parry Luke , Romero Manuel , Nisisako Takasi , Williams Paul , Wildman Ricky D. , Alexander Morgan R.
Published: April 2018

The attachment of Pseudomonas aeruginosa on microfluidic produced particles was shown to reduce as a function of PVA concentration retained at the surface, enabling novel structure–function relationships of biomaterial architecture.
Toxicity of graphene oxide to naked oats (Avena sativa L.) in hydroponic and soil cultures
Authors: Chen Lingyun , Yang Shengnan , Liu Ying , Mo Min , Guan Xin , Huang Liu , Sun Chao , Yang Sheng-Tao , Chang Xue-Ling
Published: April 2018

Graphene oxide showed much higher toxicity to plants in hydroponic culture than in soil culture.
Electroless plating of a Sn–Ni/graphite sheet composite with improved cyclability as an anode material for lithium ion batteries
Authors: Yang Guanhua , Yan Zhixiong , Cui Lisan , Qu Yonghao , Li Qingyu , Li Xin , Wang Yiyan , Wang Hongqiang
Published: April 2018

A Sn–Ni/graphite sheet composite is synthesized by a simple electroless plating method as an anode material for lithium ion batteries (LIBs).
Retracted Article: SNHG3 promotes proliferation and invasion by regulating the miR-101/ZEB1 axis in breast cancer
Authors: Chang Liang , Hu Zhuang , Zhou Zhenyu , Zhang Hui
Published: April 2018

In the present study, we investigated the expression and functional roles of SNHG3 in breast cancer cells, as well as the underlying mechanism of SNHG3 involved in the progression of breast cancer in vitro and in vivo.
Porous Pt3Ni with enhanced activity and durability towards oxygen reduction reaction
Authors: Mi Shuying , Cheng Na , Jiang Hao , Li Chunzhong , Jiang Haibo
Published: April 2018

Porous Pt3Ni nanocrystals of large size possess enhanced electrochemical activity and durability towards oxygen reduction reaction is preferred.
Cytotoxicity and ER stress–apoptosis gene expression in ZnO nanoparticle exposed THP-1 macrophages: influence of pre-incubation with BSA or palmitic acids complexed to BSA
Authors: Gong Yu , Li Xianqiang , Liao Guochao , Ding Yanhuai , Li Juan , Cao Yi
Published: April 2018

In a biological microenvironment, biological macromolecules could interact with nanoparticles (NPs) and consequently influence the toxicity of NPs.
Antioxidant properties of flavonoid derivatives and their hepatoprotective effects on CCl4induced acute liver injury in mice
Authors: Xiang Cen , Teng Yuou , Yao Chaoran , Li Xuehui , Cao Menglin , Li Xuzhe , Pan Guojun , Lu Kui , Galons Hervé , Yu Peng
Published: April 2018

Excessive accumulation of free radicals in the body can cause liver damage, aging, cancer, stroke, and myocardial infarction.
Upper-division chemistry students’ navigation and use of quantum chemical models
Authors: Muniz Marc N. , Crickmore Cassidy , Kirsch Joshua , Beck Jordan P.
Published: April 2018

Chemical processes can be fully explained only by employing quantum mechanical models. These models are abstract and require navigation of a variety of cognitively taxing representations. Published research about how students use quantum mechanical models at the upper-division level is sparse. Through a mixed-methods study involving think-aloud interviews, a novel rating task, and an existing concept inventory, our work aims to fill this gap in the literature and begin the process of characterizing learning of quantum chemistry in upper-division courses. The major findings are that upper-division students tend to conflate models and model components. Students, unlike experts, focus on surface features. Our data indicates two specific surface features: lexical features and a “complex equals better” heuristic. Finally, there is no correlation in our data between a student's facility with navigating models and their conceptual understanding of quantum chemistry as a whole. We analyze the data through the lens of a framework which enables us to cast model conflation as a problem of ontology.
ZIF-derived CoP as a cocatalyst for enhanced photocatalytic H2production activity of g-C3N4
Authors: Sun Xiao-Jun , Yang Dou-Dou , Dong Hong , Meng Xiang-Bin , Sheng Jing-Li , Zhang Xin , Wei Jin-Zhi , Zhang Feng-Ming
Published: April 2018

The graphitic carbon nitride (g-C3N4) photocatalyst has drawn widespread attention owing to its excellent photocatalytic hydrogen production activity.
A novel in situ diffusion strategy to fabricate high performance cathodes for low temperature proton-conducting solid oxide fuel cells
Authors: Hou Jie , Miao Lina , Hui Jianing , Bi Lei , Liu Wei , Irvine John T. S.
Published: April 2018

A novel in situ Pr diffusion strategy based on a Sm0.2Ce0.8O2−δ–Pr(Pr0.5Ba1.5)Cu3O7−δ (3 : 7 wt%) compound is developed to achieve a perovskite-related proton-blocking composite cathode Ce1−xPrxO2−δ–Ba2CeCu3O7.4–Sm2Ba1.33Ce0.67Cu3O9–CuO for BaZr0.1Ce0.7Y0.2O3−δ-based proton-conducting SOFCs.
One-step synthesis of nitrogen, sulfur co-doped carbon nanodots and application for Fe3+ detection
Authors: Qie Xingwang , Zan Minghui , Miao Peng , Li Li , Chang Zhimin , Ge Mingfeng , Gui Ping , Tang Yuguo , Dong Wen-Fei
Published: April 2018

Carbon nanodots (CDs) are novel forms of zero-dimensional carbonaceous nanomaterials, which have attracted the attention of researchers.
Polar code‐based overlapping transmission scheme for Internet of Vehicles
Authors: Chen Qixiao , Zheng Liming , Zhang Dalong , Wei Baodian , Ma Xiao
Published: April 2018

A polar code‐based overlapping transmission scheme to improve channel utilisation for Internet of Vehicles is presented. In the presented scheme, different relay nodes (RNs) are allowed to send their packets to the destination node (DN) in the same time slot and frequency band. The signals from RNs to DN are overlapped and hence non‐orthogonal. However, the information in the overlapped signals can be recovered by the proposed decoding algorithm. Numerical results show that the decoding algorithm performs well on information recovery in the presented transmission scheme.
Robust high‐multiplication factor MDLL using IIR filter‐based accumulated jitter reduction
Authors: Jee D.‐W.
Published: April 2018

A high‐multiplication factor multiplying delay‐locked loop (MDLL) with infinite impulse response filter‐based accumulated jitter reduction technique is presented. In every output clock cycle, the proposed jitter reduction loop samples the periodic jitter, accumulates it, and subtracts accumulated jitter from the next output clock period. The proposed technique is applied to 10 MHz MDLL with 32 kHz reference clock, a multiplication factor of 313, shows 38% jitter reduction, and greatly improves MDLL locking even with high‐supply noise. The MDLL implemented in 0.18 μm CMOS process consumes 42 μW and the core area is 0.043 mm2.
Power‐current controller based sliding mode control for DFIG‐wind energy conversion system
Authors: Merabet Adel , Eshaft Hisham , Tanvir Aman A.
Published: April 2018

This study presents an overall sliding mode control scheme for stator power‐current control, grid power‐current control and dc‐link voltage regulation to operate a doubly‐fed induction generator (DFIG) based wind energy conversion system. At the generator rotor side, the stator power control is achieved through controlling the rotor currents. The rotor current state model is carried out from the stator and the rotor equations of the generator under the condition of stator voltage alignment. At the grid side, a cascade control loop is applied for the dc‐link voltage regulation and the power transfer using grid and dc‐link modelling. The structure of the sliding mode control law, combination of compensating, sliding and integral terms, enhances the tracking performance and the robustness to uncertainties. The proposed control strategy is validated using an experimental DFIG wind turbine system and the results are provided to demonstrate the capabilities of the proposed control system in tracking and control under different operating conditions and robustness to uncertainties.
A new near-IR window of low extinction in the Galactic plane
Authors: Minniti Dante , Saito Roberto K. , Gonzalez Oscar A. , Alonso-García Javier , Rejkuba Marina , Barbá Rodolfo , Irwin Mike , Kammers Roberto , Lucas Phillip W. , Majaess Daniel , Valenti Elena
Published: April 2018

Aims. The windows of low extinction in the Milky Way (MW) plane are rare but important because they enable us to place structural constraints on the opposite side of the Galaxy, which has hither to been done rarely.

Methods. We use the near-infrared (near-IR) images of the VISTA Variables in the Vía Láctea (VVV) Survey to build extinction maps and to identify low extinction windows towards the Southern Galactic plane. Here we report the discovery of VVV WIN 1713−3939, a very interesting window with relatively uniform and low extinction conveniently placed very close to the Galactic plane.

Results. The new window of roughly 30 arcmin diameter is located at Galactic coordinates (l, b) = (347.4, −0.4) deg. We analyse the VVV near-IR colour-magnitude diagrams in this window. The mean total near-IR extinction and reddening values measured for this window are AKs = 0.46 and E(J − Ks) = 0.95. The red clump giants within the window show a bimodal magnitude distribution in the Ks band, with peaks at Ks = 14.1 and 14.8 mag, corresponding to mean distances of D = 11.0 ± 2.4 and 14.8 ± 3.6 kpc, respectively. We discuss the origin of these red clump overdensities within the context of the MW disk structure.
Isochrone fitting in the Gaia era
Authors: Mints Alexey , Hekker Saskia
Published: April 2018

Context. Currently, galactic exploration is being revolutionized by a flow of new data: Gaia provides measurements of stellar distances and kinematics; growing numbers of spectroscopic surveys provide values of stellar atmospheric parameters and abundances of elements; and Kepler and K2 missions provide asteroseismic information for an increasing number of stars.

Aims. In this work, we aim to determine stellar distances and ages using Gaia and spectrophotometric data in a consistent way. We estimate precisions of age and distance determinations with Gaia end-of-mission (EoM) and Tycho-Gaia astrometric solution (TGAS) parallax precisions.

Methods. To this end, we incorporated parallax and extinction data into the isochrone fitting method used in the Unified tool to estimate Distances, Ages, and Masses (UniDAM). We prepared datasets that allowed us to study the improvement of distance and age estimates with the inclusion of TGAS and Gaia EoM parallax precisions in isochrone fitting.

Results. Using TGAS parallaxes in isochrone fitting, we are able to reduce distance and age estimate uncertainties for TGAS stars for distances up to 1 kpc by more than one third compared to results based only on spectrophotometric data. With Gaia EoM parallaxes in isochrone fitting, we will be able to further decrease our distance uncertainties by about a factor of 20 and age uncertainties by a factor of 2 for stars up to 10 kpc away from the Sun.

Conclusions. We demonstrate that we will be able to improve our distance estimates for about one third of stars in spectroscopic surveys and to decrease log(age) uncertainties by about a factor of two for over 80% of stars as compared to the uncertainties obtained without parallax priors using Gaia EoM parallaxes consistently with spectrophotometry in isochrone fitting.
Gaia Data Release 2
Authors: Evans D. W. , Riello M. , De Angeli F. , Carrasco J. M. , Montegriffo P. , Fabricius C. , Jordi C. , Palaversa L. , Diener C. , Busso G. , Cacciari C. , van Leeuwen F. , Burgess P. W. , Davidson M. , Harrison D. L. , Hodgkin S. T. , Pancino E. , Richards P. J. , Altavilla G. , Balaguer-Núñez L. , Barstow M. A. , Bellazzini M. , Brown A. G. A. , Castellani M. , Cocozza G. , De Luise F. , Delgado A. , Ducourant C. , Galleti S. , Gilmore G. , Giuffrida G. , Holl B. , Kewley A. , Koposov S. E. , Marinoni S. , Marrese P. M. , Osborne P. J. , Piersimoni A. , Portell J. , Pulone L. , Ragaini S. , Sanna N. , Terrett D. , Walton N. A. , Wevers T. , Wyrzykowski Ł.
Published: April 2018

Aims. We describe the photometric content of the second data release of the Gaia project (Gaia DR2) and its validation along with the quality of the data.

Methods. The validation was mainly carried out using an internal analysis of the photometry. External comparisons were also made, but were limited by the precision and systematics that may be present in the external catalogues used.

Results. In addition to the photometric quality assessment, we present the best estimates of the three photometric passbands. Various colour-colour transformations are also derived to enable the users to convert between the Gaia and commonly used passbands.

Conclusions. The internal analysis of the data shows that the photometric calibrations can reach a precision as low as 2 mmag on individual CCD measurements. Other tests show that systematic effects are present in the data at the 10 mmag level.
GaiaData Release 2
Authors: Cropper M. , Katz D. , Sartoretti P. , Prusti T. , de Bruijne J. H. J. , Chassat F. , Charvet P. , Boyadjian J. , Perryman M. , Sarri G. , Gare P. , Erdmann M. , Munari U. , Zwitter T. , Wilkinson M. , Arenou F. , Vallenari A. , Gómez A. , Panuzzo P. , Seabroke G. , Allende Prieto C. , Benson K. , Marchal O. , Huckle H. , Smith M. , Dolding C. , Janßen K. , Viala Y. , Blomme R. , Baker S. , Boudreault S. , Crifo F. , Soubiran C. , Frémat Y. , Jasniewicz G. , Guerrier A. , Guy L. P. , Turon C. , Jean-Antoine-Piccolo A. , Thévenin F. , David M. , Gosset E. , Damerdji Y.
Published: April 2018

This paper presents the specification, design, and development of the Radial Velocity Spectrometer (RVS) on the European Space Agency’sGaiamission. Starting with the rationale for the full six dimensions of phase space in the dynamical modelling of the Galaxy, the scientific goals and derived top-level instrument requirements are discussed, leading to a brief description of the initial concepts for the instrument. The main part of the paper is a description of the flight RVS, considering the optical design, the focal plane, the detection and acquisition chain, and the as-built performance drivers and critical technical areas. After presenting the pre-launch performance predictions, the paper concludes with the post-launch developments and mitigation strategies, together with a summary of the in-flight performance at the end of commissioning.
Complementarity of two high-resolution spatiotemporal methods (hydroacoustics and acoustic telemetry) for assessing fish distribution in a reservoir
Authors: Goulon C. , Westrelin S. , Samedy V. , Roy R. , Guillard J. , Argillier C.
Published: April 2018

The complementarity of two high-resolution spatiotemporal acoustic methods, telemetry and hydroacoustics, was evaluated during the same time window to obtain fish distribution in a canyon-shaped reservoir, the Bariousses Reservoir (France). These methods act at an individual scale for telemetry and a community scale for hydroacoustics. The temporal scales are also different: telemetry offers continuous and long-term monitoring while a “snapshot” view is given by hydroacoustics. Day and night hydroacoustic surveys were carried out in this reservoir, during a 24-hour period in spring, using vertical and near-surface horizontal beaming. During this time window, 11 adult fish (length: 22–57 cm) from three species (roach, perch, and pikeperch) were tracked by telemetry. Four metrics were calculated with data collected by application of the two methods: distance to the nearest bank, distance to the tributary, fish depth, and bottom depth at the location. The contrasting (distance to the nearest bank, bottom depth) or partially similar results (distance to the tributary, fish depth) can be explained by the limitations associated with each method. The results obtained with telemetry are very sensitive to the species composition and the size of the tagged fish. The number of fish located in the epibenthic areas of the reservoir can be underestimated by hydroacoustics. This preliminary case study highlights that these methods act in a complementary way and their simultaneous use can provide better information on fish spatial distribution.
1. TherapieForum der Initiative Therapeutenkammer – Selbstverwaltung statt Fremdbestimmung
Authors: Wenzel Stephanie
Published: April 2018

Trotz Schnee, Eis und Erkältungswelle trafen sich am 3. März 2018 insgesamt 70 Ergo- und Physiotherapeuten sowie Logopäden zum 1. TherapieForum der Initiative Therapeutenkammer in Kiel. Experten beleuchteten das Thema Kammer aus unterschiedlichen Perspektiven.
Rettung aus Höhen und Tiefen – Standardtechniken der Feuerwehr
Authors: Ventzke Marc-Michael , Balkie Helmut , Kemming Gregor
Published: April 2018

Der Notarzt muss für eine effektive und erfolgreiche Einsatzabwicklung die lokalen Gegebenheiten, die Fähigkeiten der Feuerwehren und die Standardrettungstechniken kennen. Der vorliegende Artikel geht auf die Rettung mit Hubrettungsmitteln und einfaches Retten aus Höhen und Tiefen mit der Schleifkorbtrage ein.
Endoscopist factors that influence serrated polyp detection: a multicenter study
Authors: Crockett Seth , Gourevitch Rebecca , Morris Michele , Carrell David , Rose Sherri , Shi Zhuo , Greer Julia , Schoen Robert , Mehrotra Ateev
Published: April 2018

Background Serrated polyps are important colorectal cancer precursors that are variably detected during colonoscopy. We measured serrated polyp detection rate (SPDR) in a large, multicenter, cross-sectional study of colonoscopy quality to identify drivers of SPDR variation.

Methods Colonoscopy and pathology reports were collected for a 2-year period (10/2013-9/2015) from four sites across the United States. Data from reports, including size, location, and histology of polyps, were abstracted using a validated natural language processing algorithm. SPDR was defined as the proportion of colonoscopies with ≥ 1 serrated polyp (not including hyperplastic polyps). Multivariable logistic regression was performed to determine endoscopist characteristics associated with serrated polyp detection.

Results A total of 104 618 colonoscopies were performed by 201 endoscopists who varied with respect to specialty (86 % were gastroenterologists), sex (18 % female), years in practice (range 1 – 51), and number of colonoscopies performed during the study period (range 30 – 2654). The overall mean SPDR was 5.1 % (SD 3.8 %, range 0 – 18.8 %). In multivariable analysis, gastroenterology specialty training (odds ratio [OR] 1.89, 95 % confidence interval [CI] 1.33 – 2.70), fewer years in practice (≤ 9 years vs. ≥ 27 years: OR 1.52, 95 %CI 1.14 – 2.04)], and higher procedure volumes (highest vs. lowest quartile: OR 1.77, 95 %CI 1.27 – 2.46)] were independently associated with serrated polyp detection.

Conclusions Gastroenterology specialization, more recent completion of training, and greater procedure volume are associated with serrated polyp detection. These findings imply that both repetition and training are likely to be important contributors to adequate detection of these important cancer precursors. Additional efforts to improve SPDR are needed.
Organophotoredox/Copper Hybrid Catalysis for Regioselective Allylic­ Aminodecarboxylation of β,γ-Unsaturated Carboxylic Acids
Authors: Oisaki Kounosuke , Kanai Motomu , Manick Anne-Doriane , Tanaka Hirotaka
Published: April 2018

A new cooperative organophotoredox/copper catalysis allowing for the conversion of β,γ-unsaturated carboxylic acids into allylic hydrazides via radical regioselective allylic decarboxylative amination is reported. The coexistence of the copper catalyst is essential for the high yield and regioselectivity.
Highly Enantioselective Michael Addition of Dithiomalonates to Nitroolefins Catalyzed by New Bifunctional Chiral Thioureas
Authors: Yuan Jia-Ni , Liu Hui-Xia , Tian Qin-Qin , Ji Nan , Shen Kuo , He Wei
Published: April 2018

We report a highly efficient asymmetric Michael addition of dithiomalonates to trans-β-nitrooleﬁns catalyzed by versatile cinchona-based bifunctional thioureas, which provides the corresponding adducts in high yields (up to 92%) and with excellent enantioselectivities (up to 99% ee) under mild conditions. Replacement of the catalyst with its pseudo-enantiomer gives the Michael adducts with opposite configuration in similar yields and enantioselectivities.
P3 Cognitive Potential in Cochlear Implant Users
Authors: Grasel Signe , Greters Mario , Goffi-Gomez Maria , Bittar Roseli , Weber Raimar , Oiticica Jeanne , Bento Ricardo
Published: April 2018

Introduction The P3 cognitive evoked potential is recorded when a subject correctly identifies, evaluates and processes two different auditory stimuli.

Objective to evaluate the latency and amplitude of the P3 evoked potential in 26 cochlear implant users with post-lingual deafness with good or poor speech recognition scores as compared with normal hearing subjects matched for age and educational level.

Methods In this prospective cohort study, auditory cortical responses were recorded from 26 post-lingual deaf adult cochlear implant users (19 with good and 7 with poor speech recognition scores) and 26 control subjects.

Results There was a significant difference in the P3 latency between cochlear implant users with poor speech recognition scores (G-) and their control group (CG) (p = 0.04), and between G- and cochlear implant users with good speech discrimination (G+) (p = 0.01). We found no significant difference in the P3 latency between the CG and G+. In this study, all G- patients had deafness due to meningitis, which suggests that higher auditory function was impaired too.

Conclusion Post-lingual deaf adult cochlear implant users in the G- group had prolonged P3 latencies as compared with the CG and the cochlear implant users in the G+ group. The amplitudes were similar between patients and controls. All G- subjects were deaf due to meningitis. These findings suggest that meningitis may have deleterious effects not only on the peripheral auditory system but on the central auditory processing as well.
Pisotriquetral Pain Treated with Bilateral Pisiform Excision in a Collegiate Diver
Authors: Rietberg Nathan , Brown Matthew , Haase Steven
Published: April 2018

Background Pisiform excision and pisotriquetral arthrodesis are two surgical options for the treatment of pisotriquetral joint pain when conservative methods fail. However, it is unclear which option is best for patients who experience substantial, repetitive loading on their wrists and wish to preserve wrist flexibility and function.

Case Description We present a case of bilateral ulnar-sided wrist pain related to the pisotriquetral joint in a 19-year-old collegiate diver. The pain was exacerbated by activities specific to this sport that requires wrist hyperextension, namely full weight-bearing on the hands (handstands), and has an impact on the hands and wrists upon water entry during dives due to direct palmar pressure. There were no radiographic signs of arthritis; however, there were bone marrow changes on magnetic resonance imaging (MRI). Management with rest, splinting, and corticosteroid injection failed to relieve the pain and precluded his ability to return to full-time diving. Treatment consisted of bilateral pisiform excision. Postoperatively, the patient returned to full-time competitive diving with resolution of his painful symptoms.

Literature Review Pisiform excision has been shown to have successful outcomes in terms of return to play for lower impact athletes (such as badminton) but has not been reported in athletes who experience a high degree of force repetitively (such as gymnasts or divers). There is one report of pisotriquetral arthrodesis in a young gymnast with suboptimal results.

Clinical Relevance This case report demonstrates that pisiform excision is a successful treatment for elite athletes who experience repetitive, palmar force on hyperextended wrists and subsequently develop ulnar-sided wrist pain.
Carpal Pronation and Supination Changes in the Unstable Wrist
Authors: Short Walter , Werner Frederick
Published: April 2018

Background Little is known about changes in scaphoid and lunate supination and pronation following scapholunate interosseous ligament (SLIL) injury. Information on these changes may help explain why some SLIL reconstructions have failed and help in the development of new techniques.

Purpose To determine if following simulated SLIL injury there was an increase in scaphoid pronation and lunate supination and to determine if concurrently there was an increase in the extensor carpi ulnaris (ECU) force.

Materials and Methods Scaphoid and lunate motion were measured before and after sectioning of the SLIL and two volar ligaments in 22 cadaver wrists, and before and after sectioning of the SLIL and two dorsal ligaments in 15 additional wrists. Each wrist was dynamically moved through wrist flexion/extension, radioulnar deviation, and a dart-throwing motion. Changes in the ECU force were recorded during each wrist motion.

Results Scaphoid pronation and lunate supination significantly increased following ligamentous sectioning during each motion. There were significant differences in the amount of change in lunate motion, but not in scaphoid motion, between the two groups of sectioned ligaments. Greater percentage ECU force was required following ligamentous sectioning to achieve the same wrist motions.

Conclusion Carpal supination/pronation changed with simulated damage to the scapholunate stabilizers. This may be associated with the required increases in the ECU force.

Clinical Relevance In reconstructing the SLIL, one should be aware of the possible need to correct scaphoid pronation and lunate supination that occur following injury. This may be more of a concern when the dorsal stabilizers are injured.
Digital Artery Massage for Improving Ischemia after Distal Digital Replantation Surgery
Authors: Niimi Yosuke , Ito Hiroshi , Ikeda Karin , Kirita Miho , Hishiyama Junji , Sakurai Hiroyuki
Published: April 2018

Distal digital replantation is frequently associated with arterial thrombosis and/or spasm, leading ischemia in the replanted tissue. This report introduced a rescue technique for ischemia after distal digital replantation without reanastomosis. Two males, 64 and 51 years old, underwent Ishikawa subzone II finger amputations. Microsurgical replantations with vein grafts were performed. Intraoperatively, heparin and urokinase through intra-arterial infusion were given for one week. At 40 to 48 hours after surgeries, the replanted digits developed ischemia; massaging digital arteries at the proximal phalanx regions with running warm water was immediately initiated and ischemia was improved. In both cases, the replanted tissues were rescued, though a partial necrosis requiring full-thickness skin grafting was found in one case. This massage was easily, safely, and effectively performed without complications and was applicable in cases with ischemia after distal digital replantation, especially where reanastomosis was unfeasible.
Sarcoidosis Mimicking Skull Base Meningioma
Authors: Chaves Jennyfer Paulla Galdino , Mattozo Carlos Alberto , Maeda Adriano Keijiro , Filla Luciane , Piva Aline Kelly de Cezaro , Suzuki Thiago , Silva Larissa Luvison Gomes da , Francisco Alexandre Novicki
Published: April 2018

Sarcoidosis is a systemic disease characterized by granulomatous inflammation. Pulmonary and lymphatic granulomatous involvement are common. We present a rare case report of involvement of the central nervous system affecting the ocular region and mimicking optic nerve sheath meningioma. We report the case of a 79-year-old female patient with progressive visual impairment with an evolution of 4 years. A magnetic resonance imaging scan of the cranium with gadolinium and intense homogeneous contrast enhancement revealed an expansive lesion in the right optic nerve, at the height of the optic canal. The patient was submitted to the neurosurgical approach with lesion biopsy, which showed sarcoidosis of the central nervous system. Due to the rarity of central nervous system involvement, the diagnosis of this pathology may unfortunately be postponed. The present article aims to elucidate this pathology as a differential diagnosis of retro-orbital tumors.
Die Rechtsfrage: Darf ein Patient alleine im Therapieraum üben?
Authors: Bossow Karsten
Published: April 2018

„Darf ein Therapeut nach der Behandlung seinen Patienten noch allein einige Übungen im Therapieraum machen lassen, ohne dass der Therapeut dabei ist?”

Jochen Schomacher aus der Schweiz
Shedding of dual structures in the wake of a surface-mounted low aspect ratio cone
Authors: Chen Zixiang , Martinuzzi Robert J.
Published: April 2018

The periodic shedding of vortex pairs in the turbulent wake of a surface-mounted right cone of aspect ratio 0.867 protruding a thin turbulent boundary layer is investigated experimentally. A phase-averaged volumetric velocity field is reconstructed from planar stereoscopic particle image velocimetry. During a typical (phase-averaged) shedding cycle, counter-rotating base vortices alternately form. These are tilted and stretched to merge with stream-wise tip vortices. The merged structure sheds and is convected downstream. A synthesis of earlier observations suggests that a similar shedding process exists for other low aspect ratio tapered geometries and is more complex than the shedding patterns observed for cantilevered cylinders, despite similarities of the mean flow field structure.
A 3D topographical model of parenchymal infiltration and perivascular invasion in glioblastoma
Authors: Wolf Kayla J. , Lee Stacey , Kumar Sanjay
Published: April 2018

Glioblastoma (GBM) is the most common and invasive primary brain cancer. GBM tumors are characterized by diffuse infiltration, with tumor cells invading slowly through the hyaluronic acid (HA)-rich parenchyma toward vascular beds and then migrating rapidly along microvasculature. Progress in understanding local infiltration, vascular homing, and perivascular invasion is limited by the absence of culture models that recapitulate these hallmark processes. Here, we introduce a platform for GBM invasion consisting of a tumor-like cell reservoir and a parallel open channel “vessel” embedded in the 3D HA-RGD matrix. We show that this simple paradigm is sufficient to capture multi-step invasion and transitions in cell morphology and speed reminiscent of those seen in GBM. Specifically, seeded tumor cells grow into multicellular masses that expand and invade the surrounding HA-RGD matrices while extending long (10–100 μm), thin protrusions resembling those observed for GBM in vivo. Upon encountering the channel, cells orient along the channel wall, adopt a 2D-like morphology, and migrate rapidly along the channel. Structured illumination microscopy reveals distinct cytoskeletal architectures for cells invading through the HA matrix versus those migrating along the vascular channel. Substitution of collagen I in place of HA-RGD supports the same sequence of events but with faster local invasion and a more mesenchymal morphology. These results indicate that topographical effects are generalizable across matrix formulations, but the mechanisms underlying invasion are matrix-dependent. We anticipate that our reductionist paradigm should speed the development of mechanistic hypotheses that could be tested in more complex tumor models.
Excitation-wavelength-dependent terahertz wave modulation via preformed air plasma
Authors: Wu Tong , Dong Liquan , Huang Suxia , Zhang Rui , Zhang Shijing , Zhao Hang , Zhang Cunlin , Zhao Yuejin , Zhang Liangliang
Published: April 2018

We report excitation-wavelength-dependent terahertz wave modulation via a preformed air plasma created by a synchronized 800-nm laser pulse traveling orthogonal to the pump pulses. With a preformed plasma, both the modulation depth of the terahertz energy and the change in terahertz wave polarization increase with the increasing excitation-laser wavelength. The results are well explained by the photocurrent model with a wavelength-dependent ionization rate. We also experimentally detect the refractive index of the two-color field changed by the preformed air plasma. These results improve our understanding of the theoretical mechanism and expand the practical applications of terahertz wave generation and modulation.
Correlation between magnetic properties and depinning field in field-driven domain wall dynamics in GdFeCo ferrimagnets
Authors: Nishimura Tomoe , Kim Duck-Ho , Hirata Yuushou , Okuno Takaya , Futakawa Yasuhiro , Yoshikawa Hiroki , Tsukamoto Arata , Shiota Yoichi , Moriyama Takahiro , Ono Teruo
Published: April 2018

The influence of temperature on the magnetic-field-driven domain wall motion is investigated in GdFeCo ferrimagnets with perpendicular magnetic anisotropy (PMA). We find that the depinning field strongly depends on temperature. Moreover, it is also found that the saturation magnetization exhibits a similar dependence on temperature to that of the depinning field. From the creep-scaling criticality, a simple relation between the depinning field and the properties of PMA is clearly identified theoretically as well as experimentally. Our findings open a way for a better understanding of how the magnetic properties influence the depinning field in the magnetic system and would be valuably extended to depinning studies in other systems.
Condensation and dissociation rates for gas phase metal clusters from molecular dynamics trajectory calculations
Authors: Yang Huan , Goudeli Eirini , Hogan Christopher J.
Published: April 2018

In gas phase synthesis systems, clusters form and grow via condensation, in which a monomer binds to an existing cluster. While a hard-sphere equation is frequently used to predict the condensation rate coefficient, this equation neglects the influences of potential interactions and cluster internal energy on the condensation process. Here, we present a collision rate theory-molecular dynamics simulation approach to calculate condensation probabilities and condensation rate coefficients. We use this approach to examine atomic condensation onto 6-56-atom Au and Mg clusters. The probability of condensation depends upon the initial relative velocity (v) between atom and cluster and the initial impact parameter (b). In all cases, there is a well-defined region of b-v space where condensation is highly probable, and outside of which the condensation probability drops to zero. For Au clusters with more than 10 atoms, we find that at gas temperatures in the 300–1200 K range, the condensation rate coefficient exceeds the hard-sphere rate coefficient by a factor of 1.5-2.0. Conversely, for Au clusters with 10 or fewer atoms and for 14- and 28-atom Mg clusters, as cluster equilibration temperature increases, the condensation rate coefficient drops to values below the hard-sphere rate coefficient. Calculations also yield the self-dissociation rate coefficient, which is found to vary considerably with gas temperature. Finally, calculations results reveal that grazing (high b) atom-cluster collisions at elevated velocity (>1000 m s−1) can result in the colliding atom rebounding (bounce) from the cluster surface or binding while another atom dissociates (replacement). The presented method can be applied in developing rate equations to predict material formation and growth rates in vapor phase systems.
Surface plasmon dispersion in a mid-infrared Ge/Si quantum dot photodetector coupled with a perforated gold metasurface
Authors: Yakimov A. I. , Kirienko V. V. , Armbrister V. A. , Bloshkin A. A. , Dvurechenskii A. V.
Published: April 2018

The photodetection improvement previously observed in mid-infrared (IR) quantum dot photodetectors (QDIPs) coupled with periodic metal metasurfaces is usually attributed to the surface light trapping and confinement due to generation of surface plasmon waves (SPWs). In the present work, a Ge/Si QDIP integrated with a metal plasmonic structure is fabricated to experimentally measure the photoresponse enhancement and verify that this enhancement is caused by the excitation of the mid-IR surface plasmons. A 50 nm-thick gold film perforated with a 1.2 μm-period two-dimensional square array of subwavelength holes is employed as a plasmonic coupler to convert the incident electromagnetic IR radiation into SPWs. Measurements of the polarization and angular dependencies of the photoresponse allow us to determine the dispersion of plasmon modes. We find that experimental dispersion relations agree well with that derived from a computer simulation for fundamental plasmon resonance, which indicates that the photodetection improvement in the mid-IR spectral region is actually caused by the excitations of surface plasmon Bloch waves.
Frankenstein's Machine: Redressing Mark Oliphant’s Scientific Reputation
Authors: Keeble Kathryn M.
Published: April 2018

This paper scrutinizes criticisms of Mark Oliphant and his quest to build a cyclo-synchrotron in Canberra in the 1950s by analysing various portrayals of him, paying particular attention to the ways these portrayals, despite being written in different decades, are teleologically driven and reinforce a perception of failure. It addresses the key criticisms levelled at Oliphant: his ‘difficult' personality, his perceived political naïveté and his inability to adjust to the new technological paradigm of Big Science. It questions whether these portrayals represent legitimate criticism or ideological positioning.
Cotreatment with RepSox and LBH589 improves the in vitro developmental competence of porcine somatic cell nuclear transfer embryos
Authors: Luo Zhao-Bo , Jin Long , Guo Qing , Wang Jun-Xia , Xing Xiao-Xu , Xuan Mei-Fu , Luo Qi-Rong , Zhang Guang-Lei , Yin Xi-Jun , Kang Jin-Dan
Published: April 2018

Accumulating evidence suggests that aberrant epigenetic reprogramming and low pluripotency of donor nuclei lead to abnormal development of cloned embryos and underlie the inefficiency of mammalian somatic cell nuclear transfer (SCNT). The present study demonstrates that treatment with the small molecule RepSox alone upregulates the expression of pluripotency-related genes in porcine SCNT embryos. Treatment with the histone deacetylase inhibitor LBH589 significantly increased the blastocyst formation rate, whereas treatment with RepSox did not. Cotreatment with 12.5 μM RepSox and 50 nM LBH589 (RepSox + LBH589) for 24 h significantly increased the blastocyst formation rate compared with that of untreated embryos (26.9% vs 8.5% respectively; P < 0.05). Furthermore, the expression of pluripotency-related genes octamer-binding transcription factor 4 (NANOG) and SRY (sex determining region Y)-box 2 (SOX2) were found to significantly increased in the RepSox + LBH589 compared with control group at both the 4-cell and blastocyst stages. In particular, the expression of NANOG was 135-fold higher at the blastocyst stage in the RepSox + LBH589 group. Moreover, RepSox + LBH589 improved epigenetic reprogramming. In summary, RepSox + LBH589 increases the expression of developmentally important genes, optimises epigenetic reprogramming and improves the in vitro development of porcine SCNT embryos.