bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advances in Imprinting Disorders
Authors: Hussain Naveed
Published: September 2017

Genetic imprinting is a biological phenomenon arising from the fact that maternal and paternal contributions to the offspring’s autosomal genes have specific markers or imprints. These imprints contribute uniquely to gene expression based on the parent of origin of the active allele. The discovery of disorders of imprinting is relatively new; in 1989, Prader-Willi syndrome (PWS) was first recognized as an imprinting disorder in humans. It was found that in PWS, despite the presence of normal amount and sequence of DNA material, there is abnormal DNA methylation-induced silencing of the paternal SNRPN gene (on chromosome 15q11q13) that should be normally active in healthy individuals. In such conditions, conventional genetic analyses based on evaluation of DNA sequences may not be diagnostic unless special attention is paid to identifying the parental contributions at specific DNA sites identified as imprinting sites or “differentially methylated regions” in the genome. To date, at least 100 imprinted genes and 12 imprinting disorders have been characterized in humans, and the list is still growing. The use of new and sophisticated molecular techniques for studying genetic and epigenetic phenomena have greatly helped in advancing knowledge in this field. The recognition of various types of epigenetic modifications and their timing of imprint establishment in the human life cycle is providing insights into therapeutic manipulation of the “imprintome” for the prevention and treatment of imprinting disorders. This review summarizes the recent progress made in recognition, diagnosis, and treatment of imprinting disorders.
Intervenciones docentes en la tarea de leer para responder cuestionarios
Authors: Rosli Natalia , Carlino Paula
Published: September 2017

Al considerar que la lectura y la escritura tienen potencialidad epistémica como instrumentos de pensamiento y desarrollo de nuevos conocimientos, este artículo focaliza la enseñanza de contenidos disciplinares con ayuda de leer y escribir en materias del nivel secundario. El objetivo principal de esta investigación fue describir y analizar las intervenciones realizadas  por tres docentes argentinos en la tarea de leer para responder cuestionarios, dicha actividad es recurrente en un curso con estudiantes de sectores socioeconómicos desfavorecidos. No se han encontrado estudios que aborden prácticas de enseñanza mediadas por la lectura y la escritura en asignaturas con población de esta procedencia. En concreto, los y las estudiantes  de esta escuela son trabajadores y madres y padres adolescentes que habitan en una villa. Bajo una metodología cualitativa, se diseñó un estudio de casos naturalista y se entrevistó en profundidad a los tres profesores y los catorce estudiantes.  Se observaron 39 clases y se recogieron documentos. Las transcripciones de las entrevistas y las observaciones de clases se analizaron  mediante estrategias de categorización y contextualización. Los resultados muestran que los profesores intervienen a través de tres funciones –definición del medio, gestión del medio y evaluación de la tarea– que comprometen a los estudiantes en la tarea, pero que escasamente indagan por sus interpretaciones acerca de lo que están leyendo. Redefinir la estructura de esta actividad, mediante la promoción en clase de usos entramados de la lectura, la escritura y el diálogo – como expresar las interpretaciones y debatir sobre ellas– ofrecería a los estudiantes posibilidades de acceder, comunicar y reflexionar sobre el conocimiento, al tiempo que colaboraría con el objetivo de equidad educativa
Chaplains, their History and the Theology of R. A. Lambourne
Authors: Booth Jenifer
Published: September 2017

The author considers the tension between the psychiatric patient’s need for the full healing resources of a given religion and the need for the NHS to give equal attention to everyone. This is considered for one particular religion – Christianity – because that is the one with which the author is most familiar. However, the point applies to other world religions too. Recent developments in chaplaincy in the NHS in Scotland are discussed: “generic chaplaincy”, a new definition of spirituality and increased supervision of chaplains. The historical and theological background is considered and use is made of Tony Walter’s models of different ways of delivering chaplaincy in hospital. To elucidate the healing resources of Christianity, work on the interface between medicine and theology completed by R. A. Lambourne is brought in. Conclusions are drawn for mental health chaplaincy.
Competencia de los cuidadores familiares para cuidar a los pacientes con falla cardíaca
Authors: Achury Saldaña Diana Marcela , Restrepo Sánchez Andrés , Torres Castro Natalia Marcela , Buitrago Mora Angie Lorena , Florez Paola Devia
Published: September 2017

Introducción: El cuidador familiar es la fuente más importante de apoyo social y requiere desarrollar habilidades para reforzar las conductas de autocuidado en su familiar. El objetivo de este estudio fue determinar la competencia de cuidado de los cuidadores familiares de los pacientes con falla cardiaca (FC) en una institución de cuarto nivel de complejidad. Materiales y Métodos: Estudio descriptivo de corte transversal. Con un tamaño de muestra de 41 cuidadores familiares de personas con FC que asisten al programa de FC en una institución de salud de cuarto nivel, durante el segundo semestre del 2016. Para la recolección de la información se utilizó el instrumento “CUIDAR” que cuenta con pruebas de validez de constructo y consistencia interna con un alfa de Cronbach de 0.93. Se realizó un análisis descriptivo con distribución de frecuencias absolutas y relativas. Resultados: El nivel de competencia global para el cuidado en el hogar de los cuidadores familiares de los pacientes con FC fue medio y alto. Las dimensiones que alcanzaron un nivel más alto de competencia fueron Disfrutar e Instrumental y Procedimental. Discusión: Una adecuada competencia para el cuidado en los cuidadores se convierte en un factor que puede influir de manera positiva en el manejo de la persona. Conclusiones: Una adecuada competencia del cuidador familiar va a permitir una mejor adaptación a los nuevos requerimientos de la vida del paciente con su enfermedad y pueden ayudar a prevenir las descompensaciones.Cómo citar este artículo: Achury DM, Restrepo A, Torres NM, Buitrago AL, Neira NX, Devia P. Competencia de los cuidadores familiares para cuidar a los pacientes con falla cardíaca. Rev Cuid. 2017; 8(3): 1721-32. http://dx.doi.org/10.15649/cuidarte.v8i3.407
Autopsia verbal en hombres adultos con diabetes tipo 2: estudio cualitativo
Authors: Mendoza-Catalán Geu , Gallegos-Cabriales Esther C. , Figueroa-Perea Juan Guillermo
Published: September 2017

Introducción: La diabetes mellitus tipo 2 (DMT2) es un padecimiento crónico cuya incidencia se incrementa en forma alarmante. El objetivo fue identificar los factores asociados al no autocuidado en hombres con muerte prematura y diagnóstico de DMT2. Materiales y Métodos: Se realizaron seis entrevistas cualitativas a familiares de hombres con DMT2 que fallecieron por complicaciones de su enfermedad, utilizando la metodología de la autopsia verbal. Los resultados se analizaron mediante el análisis de contenido. Resultados: Dentro de los factores que surgieron como limitantes para el autocuidado fueron: la negación de la DMT2, el trabajo, el machismo, preferencia en los alimentos, apoyo familiar, el consumo de alcohol, el consumo de tabaco y la depresión. Discusión: Los hombres con DMT2 se ven influenciados por diversas circunstancias que limitan cuidarse, atenderse y por consiguiente presentar desventajas de salud, complicaciones e incluso una muerte temprana. Conclusiones: Desde la perspectiva de enfermería los resultados ayudan a comprender el comportamiento de los hombres ante esta enfermedad en donde se requiere cuidado constante, a la par que una conciencia legítima de que no se deja de ser hombre por cuidarse. Cómo citar este artículo: Mendoza-Catalán G, Gallegos-Cabriales EC, Figueroa-Perea JG. Autopsia verbal en hombres adultos con diabetes tipo 2: estudio cualitativo. Rev Cuid. 2017; 8(3): 1786-98. http://dx.doi.org/10.15649/cuidarte.v8i3.420
Effect of thermal environment on performance of broiler chickens using fuzzy modeling
Authors: Damasceno Flávio Alves , Cassuce Déborah Cunha , Abreu Lucas Henrique Pedrozo , Schiassi Leonardo , Tinôco Ilda de Fátima Ferreira
Published: September 2017

ABSTRACT This study aimed to develop a decision-support system based on fuzzy set theory, which can estimate welfare depending on the production responses of broiler chickens raised in climatic chambers. In the first phase, the influence of four different air temperature conditions on the performance of broilers was identified. Thus, the effect of air temperature on productivity was evaluated. In the second phase, a model was developed using the fuzzy set theory, in which feed intake responses, weight gain, and feed conversion were established according to age and the air temperature at which the birds were maintained, obtaining an efficient evaluation of the thermal environment. The results indicate that the proposed methodology is a promising technique for the determination of the level of thermal comfort endured by broilers, capable of assisting in making decisions on control of the thermal environment, avoiding productivity losses.
Yield and nutritional efficiency of corn in response to rates and splits of nitrogen fertilization
Authors: Amado Telmo Jorge Carneiro , Villalba Enrique Oswin Hahn , Bortolotto Rafael Pivotto , Nora Douglas Dalla , Bragagnolo Jardes , León Enrique Asterio Benítez
Published: September 2017

ABSTRACT Despite its relevance, nitrogen is poorly utilized by the plants when improperly applied. Thus, the objective of this study was to evaluate the yield and nitrogen use efficiency (NUE) in corn in response to doses and split application of nitrogen fertilization. The experimental design was a randomized block design, with three replications. Doses of nitrogen of 0, 30, 60 and 180 kg ha-1 were applied at sowing in order to create different nutritional status of corn plants and to obtain different values of Normalized Difference Vegetation Index (NDVI) measured with “Greenseeker®” optical sensor. The subplots with nitrogen doses in topdressing of 0, 30, 60 and 90 kg ha-1 at V8 and a dose of 60 kg ha-1 at V12 were placed in experimental plots with doses of 0, 30, 60 and 180 kg ha-1 of nitrogen at sowing. Moreover, NUE was calculated in the experiment using agronomic indexes determined by applications of nitrogen in late topdressing (V8 and V12) and contrasted to the possible combinations at doses of 60, 90 and 120 kg ha-1 of total N applied. The results showed the occurrence of a linear relationship between nitrogen fertilizer dose and NDVI at V8 as well as at V12 stages. Late topdressing fertilizations (V12) did not cause a decrease in grain yield when combined with nitrogen fertilization at sowing, moreover resulted in higher NUE. Split the nitrogen dose showed better NUE than the combinations where nitrogen was not applied at sowing or in topdressing. The delay of nitrogen topdressing can be an alternative for the planning of the moment of the N fertilization according to the climate forecast in each region.
Action of ethylene on postharvest of summer squash ‘Menina Brasileira’
Authors: Araújo Fernanda Ferreira de , Costa Lucas Cavalcante da , Silva Tania Pires da , Puiatti Mário , Finger Fernando Luiz
Published: September 2017

ABSTRACT The purpose of this study was to evaluate the sensitivity and the physiological responses of summer squash ‘Menina Brasileira’ to ethylene. Immature fruits were harvested and placed in 20 L sealed buckets, in which ethylene was applied at concentrations of 0.1, 1.0, 10, 100, and 1000 μL L-1 for 24 h. Fruits were placed in buckets with no ethylene as a control treatment. Thereafter, the fruits were taken out of the buckets and maintained on bench, wherein on days 0, 2, 4, 6, and 8, they were evaluated regarding the accumulated fresh weight loss, soluble sugars, reducing and non-reducing sugars, starch, total chlorophyll, content of malondialdehyde, and electrolyte leakage. Fruits of summer squash ‘Menina Brasileira’ showed sensitivity to exogenous ethylene with no weight loss stimulation. Additionally, the fruits exhibited small changes in nutritional quality attributes and changes in the external fruit appearance, including decreased chlorophyll content as well as damage to cell membrane characterized by increase in malondialdehyde content and electrolyte leakage. These changes were stimulated by increasing exogenous ethylene concentration.
Morfoanatomia foliar de azevém no sub-bosque de espécies arbóreas em sistemas agroflorestais
Authors: Schmidt Denise , Caron Braulio Otomar , Pilau Janine , Nardino Maicon , Elli Elvis Felipe
Published: September 2017

RESUMO A verificação das modificações que ocorrem na planta, em função da aclimatação ao sombreamento, auxilia na seleção de espécies forrageiras adequadas para o uso em sistemas agroflorestais. O objetivo deste estudo foi avaliar a morfoanatomia foliar de azevém (Lolium multiflorum Lam.), no sub-bosque de espécies arbóreas em sistemas agroflorestais. O experimento foi conduzido no município de Frederico Westphalen, RS, entre junho e setembro de 2012, em delineamento experimental de blocos ao acaso. O azevém anual foi semeado em três ambientes: radiação solar plena, sub-bosque de angico-vermelho (Parapiptadenia rigida Benth.) e canafístula (Peltophorum dubium Spr. Taubert), com três repetições. As espécies florestais foram distribuídas em cinco renques, separados por 6,0 m cada. Foram avaliadas as seguintes variáveis: radiação fotossinteticamente ativa incidente (RFAi), transmissividade da RFAi, área foliar específica, espessura do mesofilo foliar, espessura da parede periclinal externa mais cutícula, tamanho do estômato e densidade estomática. A presença das espécies florestais provoca alterações nas condições luminosas do ambiente de produção do azevém e ocasiona ajustes nas folhas dessa espécie, os quais resultam no aumento da área foliar específica, na diminuição do mesofilo e na espessura da parede periclinal externa mais cutícula, bem como no aumento da quantidade e tamanho dos estômatos. Esses ajustes resultam da capacidade de aclimatação do azevém, que nas condições de baixa luminosidade, altera sua morfologia em busca de radiação solar e aumenta a área fotossintética.
Associação entre genótipos de feijoeiro, silício e nim no controle da mosca-branca Bemisia tabaci (Gennadius, 1889) biótipo B (Hemiptera: Aleyrodidae)
Authors: Peixoto Marília Lara , Boiça Junior Arlindo Leal
Published: September 2017

RESUMO A mosca-branca Bemisia tabaci biótipo B causa grandes prejuízos ao feijoeiro, principalmente pela transmissão do vírus do mosaico dourado. O objetivo deste trabalho foi avaliar o efeito da associação de genótipos de feijão comum, com doses de óleo de nim e silício, no desenvolvimento e oviposição da mosca-branca. Os experimentos foram conduzidos em casa de vegetação, do Departamento de Fitossanidade da FCAV/UNESP, realizando-se dois experimentos para oviposição, ambos com e sem chance de escolha, e o teste de antibiose. De acordo com os dados obtidos, pode-se concluir que no primeiro experimento de oviposição, o silício 1% reduziu a oviposição da mosca-branca, em teste com chance de escolha, e o nim 1% reduziu a oviposição em ambos os testes. O óleo de nim proporcionou alta mortalidade de ninfas. No segundo experimento de oviposição, o menor número de ovos foi na dose de nim 0,75%, para o teste com chance de escolha, e a dose de nim 1% foi melhor para o teste sem chance.
Growth performance of castor bean hybrids under different plant densities
Authors: Pivetta Laerte Gustavo , Tomaz Camila de Aquino , Fioreze Samuel Luiz , Lara-Fioreze Ana Carolina da Costa , Pivetta Laércio Augusto , Zanotto Maurício Dutra
Published: September 2017

ABSTRACT Castor bean grown at high plant densities can increase yield due to increased light interception and reduction in sink demand. The objective of this study was to evaluate the effect of plant density on growth of castor bean hybrids. The experiment was conducted in Botucatu, SP, Brazil, in a split plot randomized block design, with four replications, in 2011 and 2012. The main plot consisted of the sampling times and the subplots consisted of a 3x3 factorial, with the 3 genotypes in the first factor and the 3 plant densities in the second factor. The variables analyzed were: dry mass of leaves, stems, racemes, and total dry matter, which were measured at 30, 60, 90, 120 and 150 days after emergence (DAE). Data were examined for significant differences using analysis of variance followed by the F test (p < 0.05). When interaction was found between the factors and sampling the means were analyzed by regression analysis (p < 0.05). Growth performance was higher in 2012 because of the greater water availability. In 2011, under lower rainfall, there was less branching resulting in cycle end, with total leaf loss. High plant densities partially suppress the development of higher-order structures, especially when associated with water restriction.
Growth, Plastochron, and the Final Number of Nodes of China Pink Seedlings Grown on Different Substrates
Authors: Milani Marília , Martins Juliano Dalcin , Lopes Sidinei José , Streck Nereu Augusto
Published: September 2017

ABSTRACT The objective of this work was to plot the growth curves and determine the plastochron and the final number of nodes of China pink seedlings grown on different substrates. Thus, 392 China pink seedlings were grown on seven substrates under greenhouse conditions, in Santa Maria in the state of Rio Grande do Sul, Brazil. The growth curves were plotted using the logistic model. The plastochron was estimated by the inverse of the angular coefficient of the simple linear regression between the number of accumulated nodes and accumulated thermal sum from the subsampling of the seedlings. In all substrates, the logistic model fit better for the variable number of leaves than for the plant height. The plants in substrates with 50% of soil plus 50% of rice husk ash, and 80% of rice husk ash plus 20% earthworm humus had the longest cycles with 74 and 65 days, respectively. They completed the cycles with a thermal sum of 1317.9 ºC day for number of leaves and plant height. The growth curves that were plotted by the logistic model and the plastochron of the China pink seedlings are dependent on the type of substrate used. The commercial substrate Mecplant® had the best results. The average final number of nodes of the main stem of the plants was 14 for all substrates.
Influência da adubação potássica na qualidade e no potencial antioxidante do sapoti em diferentes estádios de desenvolvimento
Authors: Costa Laíse Nascimento , Morais Patrícia Lígia Dantas de , Leite Grazianny Andrade , Almeida Maria Lucilania Bezerra , Miranda Maria Raquel Alcântara de , Fernandes Paula Lidiane de Oliveira
Published: September 2017

RESUMO A composição química e o estádio de maturação podem interferir no ponto de colheita do sapoti, a depender da destinação do fruto. Consequentemente, objetivou-se, com este trabalho, avaliar a influência da adubação potássica na qualidade e no potencial antioxidante do sapoti, em diferentes estádios de desenvolvimento. O experimento foi instalado na fazenda Norfruit, em Pau Branco, Mossoró, RN. O delineamento adotado foi em blocos casualizados, em esquema fatorial 5 x 6, composto por cinco doses de potássio (0, 200, 400, 600 e 800 g de K por planta) e seis estádios de desenvolvimento, com cinco repetições. Os frutos foram marcados ao atingirem 10 a 15 mm de comprimento; sendo colhidos e avaliados 90, 120, 150, 180 e 200 dias após sua marcação e completamente maduros (após oito dias de armazenamento a 25 ± 2 ºC e 58 ± 5% UR). O sapoti pode ser colhido 200 dias após a floração plena, quando atinge seu tamanho máximo e apresenta qualidade adequada para o consumo. O sapoti maduro tem maior teor de açúcares e menor concentração de compostos bioativos e atividade antioxidante. A dose de 400 g por planta de K proporciona frutos de maior massa, com maiores concentrações de polifenóis extraíveis totais e atividade antioxidante. A atividade antioxidante do sapoti está mais correlacionada com a concentração de polifenóis extraíveis totais.
Variabilidade espacial das concentrações de nutrientes foliares da soja correlacionadas com atributos químicos de um Latossolo Vermelho distroférrico
Authors: Gazola Rodolfo de Niro , Lovera Lenon Henrique , Celestrino Thiago de Souza , Dinalli Raíssa Pereira , Montanari Rafael , Queiroz Hernandes Andrade
Published: September 2017

RESUMO O estudo dos atributos do solo e da planta, por meio da geoestatística e da consequente geração de mapas de manejo, resulta na utilização racional de fertilizantes e, assim, na redução de custos para o produtor. No ano agrícola de 2013/2014, no município de Selvíria, MS, objetivou-se, com este estudo, avaliar as dependências linear e espacial dos atributos Ca, Mg, H+Al, Al, SB e CTC de um Latossolo Vermelho distroférrico, com as concentrações foliares de Ca, Mg, S, Cu, Fe, Mn e Zn da soja (Glycine max L.) cultivada em plantio direto. Foi instalada uma rede amostral, para a coleta de dados do solo e das plantas, com 100 pontos amostrais distribuídos, aletoriamente, em uma área de 7.980 m2. Os resultados da análise geoestatística mostraram que para os atributos avaliados houve dependência espacial. Os menores alcances observados foram os das constantes variações da área pelo preparo de um sistema de produção. Tanto linear quanto espacialmente, a CTC do solo foi bom indicador das concentrações foliares de Ca e de S da soja sob plantio direto.
CULTURAS JUVENIS ASSEMBLEIANAS
Authors: Prates Daniela Medeiros de Azevedo , Garbin Elisabete Maria
Published: September 2017

Resumo: O presente artigo analisa a constituição de sujeitos-jovens assembleianos na contemporaneidade, ancorando-se nos referenciais teórico-metodológicos dos Estudos Culturais em Educação, dos estudos sociológicos e antropológicos sobre juventudes e religião. Metodologicamente, a pesquisa desenvolveu-se mediante a inserção etnográfica junto a jovens da Igreja Evangélica Assembleia de Deus no município de Novo Hamburgo, no Rio Grande do Sul, Brasil, entre os anos de 2011 e 2012, bem como na comunidade assembleiana de Lisboa, Portugal, em 2013. Infere-se que há reconfigurações na constituição dos sujeitos na contemporaneidade, percebidas nas formas de pertencimento e nos sentidos de vivenciar a condição de ser evangélico, o que não remete a formas de resistência juvenil, mas a novos modos de existência evocados pela condição de ser/estar jovem, afinal, ao mesmo tempo que buscam se manter portadores da promessa de salvação, os jovens ensejam ser portadores da condição juvenil.
GERENCIANDO O ESTIGMA DO PROFESSOR CONTRATADO: UMA ANÁLISE DE DISCURSO CRÍTICA
Authors: Freund Cristina Spolidoro , Biar Liana de Andrade
Published: September 2017

Resumo: O artigo analisa o trabalho exercido por professores contratados em Instituições Federais de Ensino (IFEs) a partir de uma perspectiva discursiva. Assume-se que diferenças contratuais e de direitos, que precarizam relações de trabalho de professores contratados, são retroalimentadas no campo simbólico por escolhas lexicais - “efetivos” e “contratados” - que acirram a polarização entre essas categorias docentes. Em empreitada interdisciplinar, conjugando estudos sobre trabalho docente com o arcabouço teórico-metodológico da Análise de Discurso Crítica, amostra de corpus constituído por 18 autoavaliações escritas por professoras contratadas em situações reais de comunicação com a instituição foi analisada com os objetivos de identificar: marcas linguístico-discursivas usadas em sua representação e de seu trabalho; estratégias de manejo do potencial estigmatizante, à luz de Goffman, da situação de contrato; e efeitos de sentido que ajudam a (des)construir a polarização entre professores efetivos e contratados.
Relevant aspects of golden retriever muscular dystrophy for the study of Duchenne muscular dystrophy in humans
Authors: Moraes Julieta Rodini Engrácia de , Malvestio Lygia Maria Mouri , Martins Isabela Mancini , Mosko Patrícia Regina Erdmann , Engracia Filho Jair Rodini , Moraes Flávio Ruas de
Published: September 2017

ABSTRACT: Golden Retriever muscular dystrophy (GRMD) is the most representative model for studying Duchenne muscular dystrophy (DMD) in humans, owing its phenotypic expression. DMD is a recessive disorder linked to the X chromosome in which the loss of dystrophin induces progressive weakness and degeneration of the skeletal and cardiac muscles, which lead to replacement by connective and adipose tissues. Onset of clinical signs occurs between 2 and 5 years of age, and many patients die from heart or respiratory failure. The main studies concerning dystrophic Golden Retrievers (DGR) sought to elucidate the pathophysiology of the disease and its clinical implications to develop therapies and alternative treatments to improve the quality of life and increase longevity of DMD patients. This review presents an overview of relevant contributions of the DGR model for elucidating DMD in humans.
Serological response to rabies virus induced by commercial vaccines in cattle
Authors: Martins Mathias , Quadros João Motta de , Flores Eduardo Furtado , Weiblen Rudi
Published: September 2017

ABSTRACT: The antibody response to rabies virus (RABV) induced by commercial vaccines in heifers was investigated. For this, 84 heifers were vaccinated twice (30 days interval) with each of four vaccines (G1 = 14 animals; G2 = 24; G3 = 22 and G4 = 24) and received a booster vaccination 360 days later. Serum samples collected at different intervals after vaccination and 30 days after booster were submitted to a virus neutralizing (VN) assay for RABV antibodies. Thirty days after the second vaccine dose, 92% of the immunized animals presented VN titers ≥0.5UI/mL (geometric medium titers [GMT] 1.7 to 3.8UI/mL). At the day of the booster (360 days post-vaccination); however, the percentage of animals harboring antibody titers ≥0.5UI/mL had dropped to 31% (0-80% of the animals, depending on the vaccine), resulting in lower GMT (0.1 to 0.6UI/mL). Booster vaccination at day 360 resulted in a detectable anamnestic response in all groups, resulting in 83% of animals (65 to 100%) harboring VN titers ≥0.5UI/mL thirty days later (GMT 0.6 to 4.3UI/mL). These results indicated that these vaccines were able to induce an adequate anti-RABV response in all animals after prime vaccination (and after booster as well). However, the titers decreased, reaching titers <0.5UI/mL in approximately 70% of animals within the interval before the recommended booster. Thus, booster vaccination for rabies in cattle using the current vaccines should be performed before the recommended one-year interval, as to maintain neutralizing antibodies levels in most vaccinated animals.
O Programa Inovativo da Pequena Empresa (PIPE) da FAPESP como indutor do desenvolvimento de micro e pequenas empresas de base tecnológica
Authors: Kenski Victor Wolowski , Marcondes Reynaldo Cavalheiro
Published: September 2017

Resumo Este texto analisa a relevância do apoio ao desenvolvimento de micro e pequenas empresas de base tecnológica na forma de um “pacote” de recursos e capacidades estratégicos incorporados em um curto espaço de tempo, por meio do programa PIPE da FAPESP. A abordagem adotada foi a da Visão Baseada em Recursos (VBR) dado o foco do estudo. Adotou-se a metodologia qualitativa com a aplicação da análise de conteúdo. Os dados foram levantados com base em entrevistas com um roteiro estruturado com perguntas abertas junto aos sócios/gestores de 10 empresas de base tecnológica divididas em dois grupos, um deles constituído por empresas beneficiadas pelo PIPE e o outro por aquelas que utilizaram recursos próprios. A intenção foi comparar a sua evolução. Os resultados do estudo indicaram que o apoio do PIPE foi decisivo para favorecer o desenvolvimento das empresas beneficiadas por ele. Um dos ganhos relevantes foi o encurtamento do tempo do caminho percorrido para a disponibilização dos recursos complementares, como decorrência da combinação produtiva dos recursos e capacidades pré-existentes nas empresas com aqueles obtidos por meio do programa. Uma constatação importante foi que, para as empresas terem crescido no mercado de base tecnológica, independentemente da ajuda do PIPE, foi decisivo possuírem inicialmente uma tecnologia diferenciada, os sócios/gestores terem uma visão clara dos seus mercados e voltados à criação de valor para os seus produtos e serviços. A limitação da pesquisa está na seleção de pequenas empresas de base tecnológica com produtos muito distintos dificultando comparações sobre sucessos.
Análise das contribuições das competências individuais para a gestão da inovação com base na triangulação de métodos de pesquisa
Authors: Ubeda Cristina Lourenço , Santos Fernando César Almada , Nagano Marcelo Seido
Published: September 2017

Resumo Este artigo analisa as contribuições das competências individuais para a gestão de inovação, em duas empresas com foco estratégico de inovação e com sistemas de gestão de competências em implantação. A análise de dados conta com a triangulação de métodos que combina a definição de conceitos teóricos com o uso de métodos qualitativos e quantitativos. Para tanto, faz-se uma revisão bibliográfica sobre os elementos de competência individual e de gestão de inovação para guiar a definição de variáveis de pesquisa e a construção da proposta de uma análise comparativa das duas empresas. Conforme evidências principais da revisão bibliográfica, dos estudos de casos e das surveys, ressalta-se a importância das práticas que estimulem o desenvolvimento e o gerenciamento de competências individuais a fim de melhorar as atividades empresariais para a gestão da inovação. Os resultados do estudo permitem propor uma taxonomia para a integração entre as competências individuais e a gestão de inovação está embasada em 3 estágios: Integração Básica, Integração Intermediária e Integração Plena.
Determinação do número pi (π) por meio de uma rede quadrada de resistores idênticos
Authors: Tadeu E.V.C. , Alves L. M. , Jardim M. I. A. , Queirós W. P. , Goncalves A. M. B.
Published: September 2017

O número π em geral é descrito como o valor obtido da razão perímetro por diâmetro de uma circunferência, mas esse número aparece em várias circunstâncias nas ciências em geral, principalmente quando um sistema possui periodicidade. Neste trabalho apresentaremos uma forma de se obter experimentalmente essa constante matemática através da medida da resistência equivalente em uma malha infinita quadrada de resistores. As medidas foram realizadas ao longo do processo de construção da malha usando resistores reais e simulando-os em um aplicativo online. As medidas mostram que quanto maior a quantidade de camadas da malha, mais próximo do valor de π se aproxima. Apresentaremos também, outras as formas alternativas de realizar o experimento.
Sobre a teoria de Einstein para ondas gravitacionais e sua aplicação no estudo da radiação emitida por um pulsar binário
Authors: Ramos Matheus Pinheiro , Maluf Roberto Vinhaes
Published: September 2017

Neste trabalho mostramos de forma didática a dedução da equação de onda relacionada com as chamadas ondas gravitacionais. Veremos que as referidas ondas surgem naturalmente como soluções das equações de Einstein linearizadas, após a escolha de um sistema de coordenada (gauge) adequado. Discutiremos ainda a geração de ondas gravitacionais e a natureza quadrupolar da radiação gravitacional emitida por um sistema binário em órbita circular. Por fim, aplicaremos a teoria desenvolvida nos dados observacionais da binária de Hulse-Taylor, obtendo assim uma noção dos valores que cercam este tipo de evento e também do quão precisa é a teoria apresentada.
Secondary syphilis: The great imitator can't be forgotten
Authors: Reinehr Clarissa Prieto Herman , Kalil Célia Luiza Petersen Vitello , Reinehr Vinícius Prieto Herman
Published: September 2017

Summary Syphilis is an infection caused by Treponema pallidum, mainly transmitted by sexual contact. Since 2001, primary and secondary syphilis rates started to rise, with an epidemic resurgence. The authors describe an exuberant case of secondary syphilis, presenting with annular and lichen planus-like lesions, as well as one mucocutaneous lesion. Physicians must be aware of syphilis in daily practice, since the vast spectrum of its cutaneous manifestations is rising worldwide.
Evaluation of medical interns' attitudes towards relevant aspects of medical practice
Authors: Alves Áquila Talita Lima Santana , Alves Fernando Vinicius , Melo Enaldo Vieira , Oliva-Costa Edméa Fontes de
Published: September 2017

Summary Introduction: In traditional medical school curriculum, sixth-year is the moment in which students experience medical practice more intensively. Attitudes can be considered predictors of behaviors and actions. Evaluating them contributes to improve medical training. Objective: To evaluate attitudes during medical internship considering medical practice and associated factors in a Brazilian public university. Method: Cross-sectional study that included 69 students, based on a structured questionnaire and an attitude scale (Colares, 2002). We used descriptive statistics, with classification of the attitude tendency, clusters analysis and F-statistics. Results: The average age of the participants was 25.1±1.9, and 56.5% of them were male. Students presented positive attitudes to emotional aspects in organic diseases, primary health care, the medical contribution to the scientific advancement of medicine, and other aspects of medical activity and health politics; there were conflicting attitudes concerning mental illness and negative attitudes concerning death. Conclusion: Results show the need for interventions in order to reduce the identified conflicting and negative attitudes.
Geographical distribution of medical graduates from a public university
Authors: Ezequiel Oscarina da Silva , Lucchetti Giancarlo , Lucchetti Alessandra Lamas Granero , Senger Maria Helena , Braga Lucas , Lacerda Rafael , Filippo Marlon , Colugnati Fernando , McKinley Danette , Amaral Eliana
Published: September 2017

Summary Objective: To evaluate the geographic distribution and career trajectory of medical graduates and the factors associated with their choice of practice location. Method: A cross-sectional study involving graduates from December 2001 to December 2010 was conducted. A self-administered questionnaire collected demographics and geographic information (place of birth, place of residence at the time of medical school admission, place of residency training and practice location), and reason for choosing the current location. Statistical analyses assessed trends in geographic distribution of graduates, and identified factors associated with location choice (through the population density of the location chosen for professional practice). Results: A total of 563 graduates completed the questionnaire. Of those, 4.3% (n=24) reported family medicine as their medical specialty, 19.9% (n=112) reported other primary care specialties (internal medicine, pediatrics, surgery and obstetrics-gynecology) and the others chose subspecialties. Larger cities were more likely to be chosen for practice, particularly for newly-graduated doctors. Job invitations received during medical residency training increased the likelihood of choosing high-populated cities. In contrast, job invitations received during medical school increased the likelihood of choosing cities less populated. Amongst those in cities with lower population density, proximity to family members was an additional influencing factor; those who chose more densely populated cities did so because of better infrastructure and recreational options. Conclusion: Most of the physicians included in this study pursue subspecialties training and were practicing medicine in large cities. Knowing the multiple factors that influenced the choice of practice location can assist in planning future strategies to reduce physician workforce misdistribution.
Mueller-Hillis maneuver and angle of progression: Are they correlated?
Authors: Mendes Sofia , Silva Rita , Martins Inês , Santo Susana , Clode Nuno
Published: September 2017

Summary Objective: Mueller-Hillis maneuver (MHM) and angle of progression (AOP) measured by transperineal ultrasound have been used to assess fetal head descent during the second stage of labor. We aimed to assess whether AOP correlates with MHM in the second stage of labor. Method: A prospective observational study including women with singleton pregnancy in the second stage of labor was performed. The AOP was measured immediately after the Mueller-Hillis maneuver. A receiver-operating characteristics (ROC) curve analysis was performed to determine the best discriminatory AOP cut-off for the identification of a positive MHM. A p-value less than 0.05 was considered statistically significant. Results: One hundred and sixty-six (166) women were enrolled in the study and 81.3% (n=135) had a positive MHM. The median AOP was 143º (106º to 210º). The area under the curve for the prediction of a positive maneuver was 0.619 (p=0.040). Derived from the ROC curve, an AOP of 138.5º had the best diagnostic performance for the identification of a positive MHM (specificity of 65% and a sensitivity of 67%). Conclusion: An AOP of 138º seems to be associated with a positive MHM in the second stage of labor.
Analysis of the availability of the resources necessary for urgent and emergency healthcare in São Paulo between 2009-2013
Authors: Coimbra Silvana Hebe , Camanho Eliete Dominguez Lopez , Heringer Lindolfo Carlos , Botelho Ricardo Vieira , Vasconcellos Cidia
Published: September 2017

Summary Introduction: The Regulatory Complex is the structure that operationalizes actions for making resources available to meet the needs of urgent and emergency care in the municipality of São Paulo. In the case of urgent care, needs are immediate and associated with high morbidity and mortality. Objective: To identify the most frequently requested resources, the resolution capacity and the mortality rate associated with the unavailability of a certain resource. Method: Our study was based on data from medical bulletins issued by the Urgent and Emergency Regulation Center (CRUE) in the city of São Paulo from 2009 to 2013. Results: 91,823 requests were made over the five years of the study (2009 to 2013). Neurosurgery requests were the most frequent in all years (4,828, 5,159, 4,251, 5,008 and 4,394, respectively), followed by computed tomography (CT) scans, adult intensive care unit (ICU) beds, cardiac catheterization, and pediatric ICU beds. On average, requests for neurosurgery, adult ICU, pediatric ICU, CT scans, catheterization and vascular surgery were answered in 70%, 27%, 39%, 97%, 87% and 77% of cases. The total number of deaths relating to requests for neurosurgery, CT scans, adult ICU, pediatric ICU, catheterization and vascular surgeon assessment were 182, 9, 1,536, 1,536, 135, 49 and 24 cases, respectively. Conclusion: There is a lack of resources to meet urgent and emergency needs in the city of São Paulo.
Evaluation of bond strength of a conventional adhesive system in irradiated teeth
Authors: CARVALHO Emanuel Jordan de , CAMARA Maria Eduarda Lopes Viégas , ALMEIDA Jéssika Raissa Medeiros de , DORINI André Luís , GALVÃO Marilia Regalado
Published: September 2017

Abstract Introduction One of the most common treatments of head and neck cancer patients is radiotherapy, a treatment method which uses ionizing radiation beam and destroys tumor cells, minimizing damage to neighbor cells. Purpose To evaluate the bond strength of a conventional adhesive system in irradiated teeth. Method 24 third human molars, 12 of which were randomly exposed to radiation and prepared from the removal of occlusal enamel, then exposed to a flat dentine surface. The adhesive system Stae was applied according to the manufacturer’s instructions. Next, two 2 mm increments of resin were implemented. The samples were hemi sectioned specimens, originating shapped toothpick. To evaluate the bond strength, a micro tensile test was done with 500N load and speed of 0.5 mm/minute. Result There was no statistically significant difference between the bond strength of teeth which were or were not exposed to radiation and which used a conventional adhesive system. Conclusion Although the radiation doses applied may cause some alterations in microscopic range in dental tissues, it can be concluded that these alterations do not influence in the bond strength in dentin of irradiated teeth.
Influence of elastic modulus of intraradicular posts on the fracture load of roots restored with full crowns
Authors: MARCHIONATTI Ana Maria Estivalete , VALLI Veronica , WANDSCHER Vinícius Felipe , MONACO Carlo , BALDISSARA Paolo
Published: September 2017

Abstract Objective This study aimed to evaluate the fracture load and displacement of roots restored with posts of different elastic modulus. Material and method Thirty-six replicas of epoxy resin mixed with glass microfibers were made from an endodontically-treated human premolar root prepared to a length of 12 mm with a custom drill, leaving the apical 4 mm unprepared. Replicas were randomly restored with (n = 12): FP-LM (fiber post with low elastic modulus– 50 GPa), FP-HM (fiber post with high elastic modulus – 67 GPa) and MP (metallic post – 208 GPa), using self-curing adhesive and dual resin cement. Cores were built up with composite resin and metallic crowns were cemented in all the roots with self-adhesive resin cement with self-curing mode. Specimens were subjected to a fracture load test (45° inclination/0.5 mm/min) and displacement was registered at 100 N. Result One-way ANOVA showed that elastic modulus of the post did not affect the fracture load means (p = 0.203) (FP-LM: 237.4 ± 65.11 N; FP-HM: 236.7 ± 92.85 N; MP: 295.8 ± 108.7 N) but was statistically significant for the displacement (p < 0.00): Tukey’s test showed that FP-LM displacement mean (0.81 ± 0.15 mm) was significantly higher than those for FP-HM (0.46 ± 0.26 mm; p = 0.00) and MP (0.62 ± 0.07 mm; p = 0.04). Conclusion Posts with different elastic modulus exhibit similar fracture loads, but a lower displacement is achieved when fiber posts with a high elastic modulus and metallic posts are used.
Application of forensic luminol for blood detection in endodontic files
Authors: ARRUDA-VASCONCELOS Rodrigo , CHANTRE Letícia Gomes Ferreira , LOPES Rosangela Sabbatini Capella , LOPES Cláudio Cerqueira , BARBOSA-RIBEIRO Marlos , GOMES Brenda Paula Figueiredo de Almeida
Published: September 2017

Abstract Introduction Blood is a biological material with high potential of infectious transmission in dental environments, including herpes simplex, hepatitis and AIDS. Aim To investigate the efficacy of luminol in detecting blood in endodontic files before and after the sterilization process. Material and method Luminol was used to investigate the presence or absence of traces of blood tissue in 50 endodontic files, visible to naked eye or not, after performing endodontic treatment and after the cleaning/sterilization process. The results obtained were tabulated and statistically analyzed by using the Friedman’s test at a significance level of 5% (p<0.05). Result By naked eye, it was found that 31/50 files showed no trace of blood, 8/50 showed a slight presence of blood and 11/50 showed a considerable presence of blood after endodontic treatment. After the use of luminol, however, 16/50 endodontic files showed no trace of blood, 19/50 showed a slight presence of blood and 15/50 showed a considerable presence of blood. After the cleaning and sterilization process, no blood was detected in the files. Conclusion It was concluded that the luminol solution is effective in detecting blood tissue in endodontic files as well as in validating the cleaning/sterilization process.
Dietary patterns and associated factors among the elderly
Authors: Ferreira Marcela Previato do Nascimento , Previdelli Ágatha Nogueira , Freitas Tatiana Império de , Marques Karina Maffei , Goulart Rita Maria Monteiro , Aquino Rita de Cássia de
Published: September 2017

Abstract The aim of the present study was to identify dietary patterns among the elderly, and associate the same with sociodemographic characteristics, health and lifestyle. A cross-sectional study was carried out with a non-probabilistic sample of 295 elderly residents of both genders of the city of São Caetano do Sul, São Paulo, Brazil, who were users of public health units. Dietary patterns were identified considering 44 food items identified through 24-hour dietary recall. Factor analysis by the principal components method was used, adopting loads greater than 0.25 as the cut-off point, followed by Varimax orthogonal rotation. The associations were analyzed by the linear regression method, with variables with p<0.20 in univariate regression selected, and those with p<0.05 maintained in the multivariate model. There was a greater percentage of elderly females (85.1%) and those aged 60-69 years (46.4%). Three dietary patterns were identified: the "traditional" pattern was associated with the male gender (β=0.59, p<0.001) and physically active individuals (β=0.39, p=0.020); the "Pastas, pork and sweets" pattern was associated with the male gender (β=0.38, p=0.025) and retired individuals (β=0.55, p=0.017); and the "Coffee with milk and bread and butter" pattern was associated with an age of 80 years or older (β=0.55, p=0.004) and elderly persons who had difficulty chewing (β=0.38, p=0.013). The dietary patterns identified show that the elderly tend to maintain similar eating habits to the Brazilian population in general, and that diet changes to a similar degree as health and life style conditions.
Prevalence of Geriatric Depression and Alexithymia and their association with sociodemographic characteristics in a sample of elderly persons living in Buenos Aires, Argentina
Authors: Tartaglini María Florencia , Dillon Carol , Hermida Paula Daniela , Feldberg Carolina , Somale Verónica , Stefani Dorina
Published: September 2017

Abstract Objective: to evaluate the prevalence of Geriatric Depression and Alexithymia and their association with sociodemographic characteristics in independent elderly persons without known depression. Method: a cross-sectional study was conducted, based on a non-probabilistic, intentional type sampling strategy. A total of 176 independent men and women aged over 60 years residing in the city of Buenos Aires, Argentina, were evaluated through individual interviews using the following instruments: a sociodemographic (ad hoc) questionnaire, an adapted version of the questionnaire of the Yesavage Geriatric Depression Scale (V-15) and the Latin American Alexithymia LAC TAS-20 Scale. The Chi-squared and Student's t-tests were used and the Odds Ratio was calculated, with a probability of error less than or equal to 0.05. Results: The mean age was 73 years (+7.1 years) and 72.7% of the participants were women. The prevalence of Geriatric Depression was 35.8%, while that of Alexithymia was 50.6%. The presence of Geriatric Depression was significantly associated with the female gender and with individuals who did not work. High Alexithymia values were observed among those with primary education and a low occupational level. Conclusion: The evaluation of Geriatric Depression and Alexithymia in clinical care is recommended, and the social determinants of the health of the elderly should also be considered in the diagnosis and treatment of these conditions.