bluuebunny/crossref_metadata_2025 huggingface dataset:
СЕРВІСИ РЕПРЕЗЕНТАЦІЇ ПЕРСОНАЛЬНОГО БРЕНДУ ТА СОЦІАЛЬНОЇ ІНТЕРАКЦІЇ ГРАФІЧНИХ ДИЗАЙНЕРІВ
Authors: Гордійчук Ярослав Юрійович
Published: October 2024

Метою статті аналіз тематичного спрямування і функціональних можливостей соціальних мереж в контексті професійної діяльності графічного дизайнера. В роботі проаналізовано як загальновживані соціальні мережі (наприклад, Instagram, Facebook та інші), так і спеціалізовані (UpWork, Behance, Fiverr), досліджено функціональні можливості кожної соціальної мережі у співставленні з реальним використанням дизайнерами цих сервісів в їх професійній діяльності. В статті автор звертає увагу на важливість поняття «персонального бренду» як елемента професійної діяльності графічного дизайнера, недостатня увага до якого стає причиною уповільнення кар’єрного зросту та подальшого розвитку як спеціаліста. У зв’язку з цим вміння презентувати себе, продавати себе як спеціаліста, інтегрувати в свою діяльність технічні інновації, використовувати всі доступні засоби нагадати про себе – це нові реалії, що забезпечують конкурентоспроможність графічного дизайнера на ринку. Проведено аналіз теоретичних праць вітчизняних та зарубіжних авторів, який свідчить, що питанню використання соціальних мереж в контексті професійної діяльності графічного дизайнера та формування його персонального бренду не було приділено достатньо уваги, наявні здебільшого розпорошені відомості з різних галузей науки, зокрема соціології, маркетингу, психології та соціального маркетингу. Присутність в соціальних мережах графічного дизайнера з метою формування персонального бренду і покращення професійної діяльності розглянуто недостатньо і говорить про необхідність подальшого структурованого вивчення даного напрямку. В дослідженні виведено ряд потреб, які графічний дизайнер бажає реалізувати в контексті своєї діяльності: необхідні (завдяки яким здійснюється професійна діяльність) та додаткові (що сприяють зростанню власної фахової майстерності та впливовості на інших). Співставлено з аналізом соціальних мереж і їх можливостями забезпечити ту чи іншу потребу, з метою визначити ряд соціальних мереж з найбільшою користю для позиціонування, просування та формування власного персонального бренду графічного дизайнера.
Community Choice Electricity Aggregation and Solar Adoption: Evidence From Illinois
Authors: Bartling Hugh , Monkman Madeleine
Published: October 2024

We explore whether municipalities voting on the community choice aggregation (CCA) model of electricity procurement relates to the adoption of small-scale distributed solar in the US state of Illinois. Municipalities that held a referendum for CCA were more likely to have small-scale solar installations compared to those that did not. Among municipalities with solar installations, those that held CCA referendums have lower per capita solar power generation than those without CCA referendums. The impacts of CCA referendums on small-scale solar adoption are mixed and should be combined with other strategies to promote broader solar adoption in the U.S. energy market.
Tỷ lệ rối loạn lo âu lan toả và các yếu tố liên quan trên bệnh nhân mắc bệnh trào ngược dạ dày thực quản
Authors: Từ Thị Thảo Nguyên , Ngô Tích Linh , Trần Trung Nghĩa , Ái Ngọc Phân
Published: October 2024

Đặt vấn đề: Rối loạn lo âu lan toả là một trong những rối loạn tâm thần phổ biến nhất hiện nay, có tỷ lệ đồng mắc các rối loạn tâm thần khác và bệnh lý nội khoa tương đối cao. Những nghiên cứu gần đây bước đầu cho thấy rối loạn lo âu lan toả có mối liên quan đáng kế đến bệnh trào ngược dạ dày - thực quản (BTNDD-TQ). Tuy nhiên, hiện nay tại Việt Nam vẫn chưa có những nghiên cứu về tỷ lệ mắc phải và các yếu tố liên quan giữa hai bệnh lý trên.

Mục tiêu: Xác định tỷ lệ rối loạn lo âu lan toả trên bệnh nhân bị bệnh trào ngược dạ dày - thực quản và khảo sát thêm các yếu tố liên quan giữa hai bệnh lý.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang mô tả có phân tích được thực hiện trên 143 bệnh nhân bị BTNDD-TQ tại phòng khám tiêu hoá- gan mật bệnh viện Đại học Y Dược Thành phố Hồ Chí Minh trong thời gian từ tháng 01 năm 2024 đến tháng 03 năm 2024.

Kết quả: Tỷ lệ mắc phải rối loạn lo âu lan toả trên bệnh nhân BTNDD-TQ là 32,2%, đa số ở mức độ nhẹ theo thang

HAM-A, than phiền chính phổ biến nhất là mất ngủ. Các yếu tố liên quan bao gồm thời gian mắc bệnh ≥5 năm, có hội chứng ruột kích thích đi kèm và suy giảm chất lượng cuộc sống theo thang EQ-5D-5L.

Kết luận: Rối loạn lo âu lan toả có tỷ lệ mắc phải khá phổ biển trên bệnh nhân BTNDD-TQ. Các yếu tố như thời gian mắc bệnh ≥ 5 năm, có hội chứng ruột kích thích đi kèm và suy giảm chất lượng cuộc sống được ghi nhận có mối liên quan đáng kể.

Từ khoá: rối loạn lo âu lan toả, bệnh trào ngược dạ dày - thực quản, tỷ lệ mắc phải, yếu tố liên quan
PENGARUH DEBT TO ASSETS RATIO (DAR) DAN DEBT TO EQUITY RATIO (DER) TERHADAP RETURN ON EQUITY (ROE)
Authors: Siregar Erwin Saputra , Lubis Puteri Anggi , Hidayat Wahyu Toni
Published: October 2024

Penelitian ini bertujuan untuk mengetahui pengaruh Debt to Assets Ratio (DAR) dan Debt to Equity Ratio (DER) terhadap Return On Equity (ROE) pada perusahaan yang terdaftar di Jakarta Islamic Index (JII) periode 2018-2021. Metode yang digunakan dalam penelitian ini adalah dengan menggunakan metode penelitian kuantitatif. Sampel yang digunakan adalah Perusahaan yang Terdaftar di Jakarta Islamic Index (JII). Berdasarkan metode purpose sampling terdapat 9 perusahaan yang memenuhi kriteria. Hasil penelitian ini menunjukkan bahwa secara parsial Debt to Assets Ratio (DAR) tidak berpengaruh signifikan terhadap Return On Equity (ROE), sedangkan Debt to Equity Ratio (DER) memiliki pengaruh signifikan terhadap Return On Equity (ROE) pada perusahaan Jakarta Islamic Index. Penelitian ini juga menunjukkan bahwa secara simultan Debt to Assets Ratio (DAR) dan Debt to Equity Ratio (DER) berpengaruh signifikan terhadap Return On Equity (ROE) pada perusahaan Jakarta Islamic Index.Kata Kunci: Debt to Assets Ratio (DAR), Debt to Equity Ratio (DER), Return On Equity (ROE).
PENGARUH EFEKTIVITAS DAN EFISIENSI TERHADAP MINAT MENGGUNAKAN QRIS BRI SEBAGAI SITEM PEMBAYARAN DIGITAL PADA UMKM DI KOTA SUNGAI PENUH
Authors: Yeza Bunga Permata , Bustami Yuserizal , Syarif Dafiar
Published: October 2024

ABSTRAK
Penelitian ini bertujuan untuk mengetahui pengaruh secara parsial dan simultan efektivitas dan efisiensi terhadap minat menggunakan QRIS BRI sebagai sistem pembayaran digital pada umkm di kota sungai penuh. Jenis penelitian ini adalah penelitian kuantitatif. objek penelitian adalah pedagang UMKM di Kota Sungai Penuh sebanyak 50 responden. Teknik pengumpulan data yang yang dilakukan menggunakan kuisioner. Metode analisi data yang digunakan adalah analisis rgresi linear berganda, uji t dan f dan koefisien determinasi. Hasil penelitian ini menunjukkan bahwa 1). Secara parsial variabel efektivitas beerpengaruh terhadap minat menggunakan dengan nilai thitung 2,276 > ttabel 2.012 dan signifikansi sebesar 0,0008 < 0,050. 2). Secara parsial variabel efisiensi tidak berpengaruh terhadap minat menggunakan dengan nilai thitung 1,383 < ttabel 2,012 dan nilai signifikansi sebesar 0,173 > 0,050. Secara simultan variabel efektivitas dan efisiensi berpengaruh terhadap minat menggunakan dengan nilai fhitung 16,914 > ftabel 2, 80. Dan nilai signifikansi sebesar0,000 < 0,050
Kata Kunci : Efektivitas ,Efisiensi, Pembayaran Digital, Qris
ANALISIS STRATEGI PUBLIC RELATIONS DAN PUBLISITAS DALAM MENINGKATKAN JUMLAH NASABAH TABUNGAN EMAS DI PT. PEGADAIAN CABANG SUNGAI PENUH
Authors: Yulia Yulia , Sujadi Eko , Mailindra Wiyan
Published: October 2024

Strategi public relations dan publisitas di PT. Pegadaian Cabang Sungai Penuh dalam memasarkan tabungan emas dilaksanakan dalam bentuk promosi  dilakukan di media sosial secara berkesinambungan, peran media sosial untuk public relations dan publisitas dapat memperkuat pengaruh publik, baik dalam hal positif dan sebaliknya. Tujuan dalam penelitian ini adalah sebagai berikut: mengetahui strategi public relations dalam meningkatkan jumlah nasabah tabungan emas di PT. Pegadaian Cabang Sungai Penuh, mengetahui strategi publisitas dalam meningkatkan jumlah nasabah tabungan emas di PT. Pegadaian Cabang Sungai Penuh dan mengetahui faktor yang mendorong dan menghambat penerapan strategi  public relations dan publisitas di PT. Pegadaian Cabang Sungai PenuhJenis penelitian adalah penelitian kualitatif,  objek penelitian ini adalah Analisis Strategi public relations dan publisitas dalam Meningkatkan Jumlah Nasabah tabungan emas. Subjek Penelitian Petugas dan nasabah. Informan adalah pimpinan, Karyawan dan Nasabah PT. Pegadaian Sungai Cabang Penuh. Jenis data yaitu data primer berupa hasil wawancara dengan Karyawan dan nasabah, data sekunder berasal dari sumber tertulis.Teknik pengumpulan data yaitu observasi, wawancara dan dokumentasi. Teknik analisa data adalah Pengumpulan data, reduksi data, penyajian data, penarikan kesimpulan. Teknik pemeriksaan keabsahan data digunakan tiga triangulasi,triangulasi sumber, triangulasi metode dan triangulasi waktu. Hasil Penelitian menunjukan bahwa strategi public relations terdiri dari Strategy Of Publicity, Strategy Of Pesuation, Strategy Of Argumentation dan Strategy Of Image. Penerapan starategi publisitas oleh PT. Pegadaian Cabang Sungai Penuh dilakukan melalui 3 bentuk strategi publisitas yaitu Pure publicity Tie-In Publicity dan Paid publicity  Faktor yang mendorong  Public Relations . Faktor pendukung Public Relations dan Publisitas pihak adanya  dukungan dan semangat dari semua pihak pegadaian, selain itu adanya hubungan solit antara pimpinan dan bawahan sehingga terbentuk tim solid dalam menjalankan strategi Public Relations dan Publisitas. Faktor penghambat kurang kesadaarn masyarakat untuk mengetahui lebih jauh lagi mengenai tabungan emas, selain itu adanya keterbatasn biaya untuk mengadakan promosi itu terlihat dengan sedikitnya iklan dan brosur yang beredar di masyarakat.
Kata Kunci: strategi,  public relations,  publisitas
Лечение пациентов с лейкоплакией слизистой оболочки рта
Authors: Карпук Н.А.
Published: October 2024

Цель исследования. Разработка рационального метода лечения лейкоплакии слизистой оболочки рта.
Объекты и методы исследования. 39 пациентов получали традиционную медикаментозную терапию, включающую 5 % масляные растворы витаминов А, Е, метилурацил мазь 5-10 % ; 0,05 % раствор хлоргексидина. 41 пациент получал лечение с использованием предлагаемого нового метода. Пациентам назначали перорально витамин В2 (рибофлавин) в дозировке 1,6-1,8 мг на протяжении 24 дней. На 15-й день после начала приема витамина В2 проводили лазеротерапию на протяжении 10 дней местно один раз в день, последовательно воздействуя на очаг поражения лазерным излучением фиолетового спектра с длиной волны 405 ± 5нм и красного спектра света с длиной волны 650 ± 5 нм. Каждое поле подвергалось облучению в течение 3 минут.
Результаты исследования и их обсуждение. Разработанный метод позволяет получить стойкий выраженный лечебный эффект (р < 0,05), определяемый меньшим количеством рецидивов лейкоплакии у пациентов через 18 месяцев после лечения – 3 (7,3 %), по сравнению с 9 (23 %) – при лечении традиционным методом. После лечения предлагаемым методом нормализуется микроциркуляция слизистой оболочки рта (р < 0,05) (индекс периферического кровообращения Дедовой до лечения – 0,68, после – 0,95), а традиционным – нет (до лечения – 0,65, после – 0,69). Мониторинг качества жизни пациентов (OHIP-14) выявил статистически значимые изменения до и после лечения обоими методами, однако при сравнении показателей качества жизни установлено, что лечение предлагаемым методом максимально повышало качество жизни по сравнению с традиционным лечением.
Заключение. Предлагаемый метод является реализуемым в условиях стоматологической поликлиники безопасным, хорошо переносимым для пациентов (осложнения и побочные реакции не отмечены) и повышает эффективность лечения лейкоплакии по сравнению с традиционным (р < 0,05).
Influence of Forensic Accounting on Litigation Support and Engagement in Nigeria
Authors: Osunwole Olatunji Oludayo , Adewumi Ademola, Adeniran , Adeyemi Olatoke Adewale , Adekanye Taiwo
Published: October 2024

The research focused on the influence of forensic accounting on the objectivity of forensic accountant’s investigation and the Attorney’s judgment in litigation cases in Nigeria. The study was carried out using a descriptive survey design. The study population is the over 400 professionals and practitioners in Osogbo, Osun State which included deposit money banks, law firms, audit firms, higher education institutions as well as small and mid-sized industries. In determining the sample size, Solvin’s formula was used and 200 respondents were selected in the study while a technique of randomization and convenience sampling has been applied. For this study, primary data were used. Questionnaires have been employed as a tool for collecting data. The results of the study showed that forensic accounting (α = 0.293; p < 0.05) and (α = 0.243; p < 0.05) had positive and significant effect on the objectivity of forensic accountant’s investigation and the Attorney’s judgment in litigation cases in Nigeria respectively. The study concluded that the use of forensic accounting services in Nigeria is an effective way to obtain verifiable evidence and support for litigation that aids activities of Attorney’s in the process of prosecuting fraudsters and ensuring dispute resolution. The study recommends that management of firms in Nigeria should develop more interest in forensic accounting by recruiting more forensic accountants with good knowledge in investigative skills and litigation support services as part of their accounts and audit departments.
A COVID question: the impact on our nursing home residents
Authors: McDonagh Aoife
Published: October 2024

COVID-19, a novel coronavirus which targets the respiratory system, has had a significant impact on Irish nursing homes. The virus was declared a global pandemic in March 2020, and as of 14th June the Health Protection Surveillance Centre has reported 258 clusters of cases in nursing homes, comprising 21% of all cases in Ireland and associated with 943 deaths. This pandemic is a source of many ethical dilemmas — an example being the ethical issues arising from enforced social isolation imposed on residents during lock-down.
The cocooning of residents in nursing homes raises a question with no simple answer — does the risk this isolation poses to the wellbeing of elderly residents outweigh the benefits of such strict measures to protect them from COVID-19?
The adverse effects of isolation, although relevant in any infectious outbreak, are compounded in this instance by the unprecedented scale of the coronavirus pandemic and the immense pressure on the healthcare system as it faces this new threat to health. Even in the chaos of a global pandemic, the ethical principles at the root of all healthcare decisions, namely non-maleficence, beneficence, autonomy, and justice remain pertinent.
Right knee ACL, PCL and MCL reconstruction with sports-related anxiety
Authors: Nulkar Avnee , Najamus-Saqib Khan Kazi
Published: October 2024

Introduction: JM, a 20-year-old male professional ice hockey player, presented with a 2-week history of lack of range of motion, weakness, and pain in his right knee, after a 2-year post-medical collateral ligament repair of the right knee and 3 year-post anterior cruciate ligament, posterior cruciate ligament and medial collateral ligament reconstruction of the right knee. 
Case Description: In the course of history taken, it was revealed that 5 months prior to admission the patient had been informed by a psychiatrist that he had sport-related anxiety. With an unremarkable psychiatric history prior to age 18, the competitive nature of his sports career in addition to financial pressure may have contributed to his sports-related anxiety. His examination findings were consistent with a diagnosis of complete tears of the right anterior cruciate ligament and posterior cruciate ligament along with grade III medial collateral ligament injury. 
Discussion: The biopsychosocial model was used to explicate JM's case. JM's current injuries prompted reconstruction of the anterior cruciate, posterior cruciate, and medial collateral ligaments. Psychologically, JM's sports-related anxiety is not a rare phenomenon as recent studies have discovered an increased risk of sports-related anxiety amongst young professional athletes. Sports-related anxiety, along with competitive trait anxiety, may be factors that contribute to sports injury occurrence. Other psychological stressors can add to sports-related or competitive trait anxiety, further increasing the risk of sports injury reoccurrence. 
Summary: JM was admitted for a right knee open medial collateral ligament repair with internal bracing, anterior cruciate ligament reconstruction, posterior cruciate ligament reconstruction, and platelet rich plasma injection. As part of a holistic patient-centered treatment plan, a referral to psychiatry was made to address JM's sports-related anxiety with the goal of decreasing future risk of sports injury.
Patient's Consent Obtained: Yes
A systematic review upon the online content provided for self-management of diabetes
Authors: Najamus-Saqib Khan Kazi , Nulkar Avnee
Published: October 2024

Background: Diabetes is a major illness that requires appropriate education in order to increase one's understanding of self-management. With the advancement of the internet, the proliferation of online health-related content in supporting the management of chronic illness like diabetes has been ongoing; however, little is understood on the sort of acceptable and/or effective information attainable online. 
Objective: The aim of this review is to evaluate the current literature in hindsight of online management in diabetes whilst establishing the effectiveness of online management tools, the quality of the online information, and the methods of obtaining online information. 
Methods: A series of systematic searches of online databases were conducted in accordance with strictly defined inclusion and exclusion criteria relevant to the research question. Additionally, an evidence-based literature (EBL) checklist tool was used to assess the methodological and reporting quality of each study. Each article was peer-reviewed and screened for any biases. 
Results: A result of 11 electronic searches were critically appraised using the EBL appraisal checklist tool and all were found to have overall validity. The results indicate an increase use of online technology to empower an understanding of one's own health. Web-based tools like social media were useful in promoting the management of diabetes but were not able to provide quality information. 
Conclusion: Current research indicates the need for more investigation and future development of readily accessible and qualitative information in order to support the self-management of diabetes.
Severe maternal morbidity in high income countries
Authors: Kaskun Oleksandra
Published: October 2024

IntroductionWith declining maternal mortality rates in high income countries (HICs), severe maternal morbidity (SMM) is becoming an important quality measure of maternal care. However, there is no international consensus on the definition and types of SMM. This study aims to critically analyze published literature on SMM in HICs.
ObjectivesTo compare definitions and criteria used to identify SMM, and to identify the main types and risk factors contributing to SMM in eight HICs.
MethodsThree databases were searched, results were filtered, and ten studies were critically appraised.
ResultsSix of the articles discussed SMM identification criteria and proposed definition modifications. Longer hospital stay and admission to intensive care unit were suggested as additional criteria. Disease-based criteria was shown to be superior to organ dysfunction criteria. Seven articles detailed common types of SMM as severe haemorrhage, hypertensive disorders, and pre-eclampsia/eclampsia. Six articles described SMM risk factors, of which advanced maternal age and caesarean delivery were most common.
DiscussionThis literature review identified disease-based criteria and Canadian study criteria as promising measures of SMM. It also identified several types and risk factors of SMM common between HICs. These findings can help physicians identify women at risk of SMM. The study is however limited to eight HICs and ten studies. Further research should aim to investigate how the measures compare with previous sources of criteria, and to discern the association of weight and race risk factors with SMM.
Erasmus exchange to Lille
Authors: Ní Chuirtín Ella
Published: October 2024

Erasmus exchange to Lille
How effective is 13-valent pneumococcal conjugate vaccine (PCV13) combined with 23-valent pneumococcal polysaccharide vaccine (PPSV23)?
Authors: Fay Ng Kee
Published: October 2024

The bacterium Streptococcus pneumoniae remains a major causeof morbidity and mortality worldwide. Currently, the 2 leading vaccines targeted against it are: 23-valent pneumococcal polysaccharide vaccine (PPSV23) and 13-valent pneumococcal conjugate vaccine (PCV13). It was only very recently, starting 22 November 2019, that the Advisory Committee on Immunisation Practices (ACIP) no longer recommends routine administration of PCV13 for all adults aged 65 and above. As such, this systematic review aims to investigate how the use of PCV13 combined with PPSV23 compares to using PPSV23 alone in older adults.
Relevant research papers were chosen through an electronic searchin PubMed. A set of selection criteria was then applied to ensure that the papers aligned with the objectives of this paper.
The majority of the studies included in this paper demonstrated that in adults aged 50 years and above, PCV13 had the ability to generate a strong immune response in adults, even more so than PPSV23 for all of the twelve serotypes common to both vaccines. The safety of PCV13 was also demonstrated in the studies as no PCV13-related serious adverse events (SAEs) had surfaced. Only one study included in this systematic review opposed the trend.While the evidence for both PCV13’s and PPSV23’s ability to generate an immune response have been persuasive, more research that focuses on the clinical endpoint in older adults, as well as the incidence of pneumococcal infections in the population, could be done to fully address the main question of this paper.
The effect of homesickness on the psychological wellbeing of medical and non-medical students
Authors: Charlesworth Brynn
Published: October 2024

IntroductionHomesickness commonly affects students moving to college for the first time, causing physical, psychological, and emotional disturbances. Medical students are particularly vulnerable to distressing feelings due to the already high prevalence of mental illness and burnout within this population.
Aims & ObjectivesThis review aims to critically evaluate the current literature on homesickness and wellbeing of postsecondary students, assessing the impact of psychological distress and investigating the relationships between mental illness, medical student burnout, and their implications in medical school.
MethodsSearches of PubMed, PsychINFO, and Psychology and Behavioural Sciences Collection databases were conducted to analyse literature on homesickness, student wellbeing, and burnout. These were screened according to pre-defined criteria and articles were assessed for appropriateness.
Results12 articles successfully met the eligibility criteria. Homesickness was found to affect the majority of freshman students, associated with both a significant decrease in college adjustment and an increase in depression. Within the postsecondary population, psychological distress varied, with medical students having poorer mental health than their peers. The risk for burnout was found to be predictive of mental illness and was associated with unprofessional behaviour.
DiscussionDuring the transition to college, students are under an enormous amountof pressure – academically and psychologically. Evidence suggests that homesickness is common, with associations found between homesicknessand depression. A high prevalence of psychological distress among the post- secondary population and a positive correlation between mental illness and burnout was also found. As such, medical student homesickness and burnout should be investigated to decrease potentially devastating consequences.
Bipolar disorder and early childhood trauma
Authors: Simon Chrissy
Published: October 2024

Case Background
There is a reported 48.8 million case of bipolar disorder (BD) world- wide. It can also be one of the most challenging disorders to manage clinically as patients often have poor medical compliance and numerous relapses throughout their lifetime. The etiology of this illness is still poorly understood, but it is recognized to compromise both genetic and environmental factors. Regarding the latter, abuse and instability in childhood and adolescence was reported as an important area of consideration in regard to the development and prognosis of bipolar disorder.
We report here the case of a female who exemplifies the significance of early childhood experience in this disorder.
Case Presentation
Isabelle is a 21 year old, female, with a background history of bipolar disorder. She presented to the Cork University Hospital accident and emergency 2 weeks after discharge after a 4 week admission for a depressive episode. Isabelle was referred from the home-based team with an acute episode of mania and was detained involuntarily under the Mental Health Act. Her history is significant for childhood neglect, physical, emotional and sexual abuse, along with multiple foster care placements. She was managed as an inpatient with antipsychotics and a mood stabilizer before being discharged after a lengthy, arduous, admission.
Conclusion
Childhood trauma is an important consideration in BD. Therefore, practitioner awareness of the role of such trauma with regard to its etiology and prognosis is of great importance. It is also essential to the practice of preventive medicine.
Patient Consent Obtained: Yes
Sudden severe chest pain: an atypical presentation of an infective exacerbation of COPD
Authors: Gutman Arlene , Tellios Nikoleta
Published: October 2024

Presentation
A 59-year-old female, recent ex smoker, with a history of COPD and anxiety, presents to her GP with acute onset sharp chest pain, associated with dyspnea, diaphoresis and palpitations. On examination tachycardia, tachypnea and rhonchi were noted in the absence of fever and crepitations.
Differential Diagnosis
Her presentation raises suspicion for several conditions that require urgent treatment, including AMI, PE and pneumothorax. Few indicators of infection were present initially.
Investigations
Given the risk of life-threatening conditions included in the differential diagnosis, hospital work-up was warranted. Investigations for AMI, PE, and pneumothorax were negative. Further investigations and development of the clinical course led to the conclusion of a diagnosis of IECOPD.
Conclusion
Presentations of IECOPD can be diagnostically difficult. Although painis not usual in IECOPD and pyrexia is common, this case illustrates the absence of such features in the presence of additional atypical features. Furthermore, acute chest pain often requires hospital investigation even if the ultimate diagnosis may be managed by the GP.
A five-year retrospective review of fatalities involving novel psychoactive substances in Southern Ireland
Authors: Mazurek Andrew , Bolster Margot
Published: October 2024

Introduction: Novel psychoactive substances (NPS) are rapidly emerging and being reformulated to evade legislative controls, creating unpredictability in drug markets and ineffective drug policies. Given that Ireland has the highest self-reported NPS use within Europe and literature regarding health risks is lacking, the National Advisory Committee on Drugs has advocated for the surveillance of regional trends.
Objectives: To elucidate the demographic and autopsy findings of fatal cases involving NPS in Southern Ireland as compared to deaths involving traditional drugs of abuse (TDOA).
Methods: Post-mortem reports from the Cork-Kerry region with positive toxicology for illicit substances between 2012-2016 were retrospectively analyzed to compare NPS and TDOA cases with respect to circumstances surrounding death, toxicological results, and pathological findings.
Results: Between 2012-2016, there were 164 cases involving illicit substances in the Cork-Kerry region. NPS accounted for 17 (10.4%) cases, with an average annual mortality rate of 34.8 per 100,000 population. NPS contributed to the cause of death in 70.6% of cases where detected, compared to 43.5% for TDOA only. In both cohorts, fatal abusers were predominantly young males. Importantly, cases involving NPS showed a higher proportion of mono-drug intoxication and presentation to hospital prior to death. Autopsy findings were non-specific but commonly featured pulmonary congestion, aspiration, and cerebral oedema.
Conclusion: NPS are detected in a small proportion of medicolegal autopsies but contribute significantly to acute intoxication deaths. This study highlights the need for effective drug monitoring and enforcement strategies, along with improved management of drug toxicities presenting to hospital.
Immunogenicity and safety of Cervarix HPV-16/18 AS04-adjuvant vaccine against HPV induced cervical cancer in women (15+ years)
Authors: Zagoneanu Adina Elena
Published: October 2024

Background: The incidence of cervical cancer has decreased by over 50% from the mid-1970s to the mid-2000s. This is due in part to an increase in screening, which can identify cervical changes before they turn cancerous. Decreasing incidence rates in young women may be due to the use of the HPV vaccine. There are currently three types of HPV vaccines on the market: bivalent, quadrivalent and nine-valent HPV vaccines. These are administered in three-doses to both sexes from age 15 upwards to prevent HPV infection. Many medical systems support the vaccination of teenage girls and boys with HPV vaccines during their secondary school years in order to reduce the incidence of HPV-related cervical cancer in women. Despite the discovery of the link between HPV and cervical cancer in 1985, the beginning of vaccine production in 2002, and promotion of screening procedures since the 1960’s, cervical cancer is still the fourth most common cancer in women worldwide today.
Objective: This review aims to analyse the immunogenicity and safety of Cervarix®, also known as HPV-16/18 AS04-adjuvant vaccine, in women (15+ years) against cervical cancer.
Methods: The literature review analysing the effectiveness and immunogenicity of HPV-16/18 AS04-ADJUVANTED Vaccine against cervical cancer, was conducted by using two main databases: EbescoHost (Medline and Academic Search) and PubMed. Advanced searches were conducted using specific key words, various filters and Boolean operators ‘OR’ and ‘AND’ to find the most suitable literature. This process resulted in over 100 results. From this cohort, clinical trials were selected in accordance with the specific inclusion and exclusion criteria determined for the review. After duplicates from both databases were removed, the studies were assessed in order or title, population and objective relevance, and the top 10 most relevant articles to the title of the literature review, were selected for the literature review.
Results: The 10 clinical trials selected all obtained a minimum of 10 out of the 11 CASP requirements indicating good study quality. All 10 studies were successful in proving the immunogenicity and safety of the HPV-16/18 AS04-adjuvant vaccine in protecting women 15+ (15-55 years) from developing HPV-induced cervical cancer [15, 16, 17, 18, 19, 20, 21, 22, 23, 24]. This confers that vaccination against HPV-16/18 virus proves to be effective in preventing HPV-induced CIN and cervical cancer and is a safe to administer vaccine.
Behavioral addictions and psychosis
Authors: Aamer Kashaf
Published: October 2024

M.K* is a 27-year-old, single, unemployed male that was driven to the Emergency Department by his foster father, four weeks ago with first episode of psychiatric symptoms of tactile hallucinations, auditory hallucinations of male and female voices making inappropriate sexual comments about him, persecutory delusions and delusions of control for the past five days. M.K is a daily cannabis user of 0.5-1g use for the past 2 years and has 5.5 pack year smoking history. M.K also reports having a pornography and masturbation addiction for 2 years with marked intrusive thoughts of sexual nature the past week. M.K has no medical or psychiatric history. Recent stressor was moving out of foster father’s house 8 days ago. The symptoms led to significant impact at work which he has quit since then. On presentation, M. K showed partial insight into his third person running commentary hallucinations but believed adamantly that he was being watched, followed and controlled. He reported hearing his female neighbour stating that he has sexual interest in animals and later heard his manager making pedophilic allegations on him. M.K was so distressed, he quit work and isolated himself in his room. He reported poor concentration and lack of appetite for the past week. M.K describes his baseline mood to have “always been not the greatest” and denied anhedonia, fatigue, or sleep changes. He denied thoughts of self- harm, harm to others or suicidal ideation. Four weeks following inpatient, referral to HBCT and cannabis abstinence has shown improvement in psychiatric symptoms with absence of hallucinations, however, there has been increased symptoms of anxiety with “panic attacks”. M.K’s biological mother is reported to have history of substance misuse and sister with depressive symptoms. He continues to withdraw from society with increased time spent indoors gaming and shows emotional dependence on foster father.
Religiosity and psychosis
Authors: Malakhveitchouk Anton
Published: October 2024

Religion and spirituality (RS) have been integral aspects throughout human history, possibly being observed as far back as 500,000 years ago in the ritual treatment of skulls during the palaeolithic period. Today, despite the growth in relatively secular societies, almost 90% of the world has some RS affiliation. Interestingly enough, mental health has historically been interlinked with RS. Family and adoption studies show that a family history of psychosis is correlated with intense interest in RS. Furthermore, the association between Postictal psychosis, a common complication of epilepsy, with religiosity is well documented. It is conceivable that this association led to epilepsy being historically linked with the divine, demonic and supernatural. In fact, there is ample evidence to suggest that many historic religious figures had epilepsy and psychosis. In clinical practice - and in broader society - the incidence of religiosity in epilepsy patients is likely underestimated. While postictal psychosis symptoms range in RS intensity, it is not uncommon for patients to have severe RS delusions and even convert after episodes.
CHILD PARTICIPATION IN CARTOONS: THE EXAMPLE OF TURKISH RADIO AND TELEVISION CORPORATION CHILDREN'S CHANNEL
Authors: Bayraktaroğlu Fatma , Akyol Tuğçe
Published: October 2024

It is considered necessary to support the participation of children socially, and media tools having a significant effect on individuals today should reflect child participation. The aim of this study was to examine the right to participate in cartoons prepared for primary school children. The study was conducted with a descriptive survey model. The sample of this study was determined by criterion sampling and consists of a total of 10 cartoons on the TRT Children’s channel for primary school children. The data were collected with a checklist and were analysed with descriptive analysis. As a result of the research, it was determined that in the cartoons, child-led participation was the most common level of participation, while collaborative participation was the least common. Furthermore, it was determined that the qualities of participation in cartoons were mostly related, voluntary and respectful and the safe and sensitive to risk were the least.
Keywords: children’s participation, media, primary school children, right to participate
DIGITAL TRANSFORMATION OF ECONOMIES THROUGH TECHNOLOGY, EDUCATION AND COMPETENCES
Authors: Uzule Kristine , Gobniece Zanda , Titko Jelena
Published: October 2024

Digital transformation has profoundly impacted social and economic life by enhancing workforce competences, fostering innovation, and creating competitive advantages. Given that the driving force of digital transformation is technology, this study aimed to determine whether education and workforce competences are perceived as essential factors in the digital transformation narrative across diverse fields of socioeconomic development at both macro and micro levels. To achieve this, 528 abstracts from various scientific fields focused on digital transformation were analyzed using both manifest and latent content analyses, the latter ensuring a more objective interpretation of the outcomes derived from manifest content analysis. Frequency, word linkage, and concordance analyses of key concepts were used. The results indicated that education and workforce competences are viewed as vital for the digitalization of various sectors of the economy at both macro- and micro-level development. The findings suggest that technology drives digital transformation by delivering different types of value, including innovation and sustainability, while relying on education and technology-related competences. The results also revealed concerns about barriers to technology implementation, which could be overcome through education and competences. The originality of this research lies in its application of both manifest and latent analyses to identify the roles of education and technology in driving economic digital transformation.
Keywords: digital transformation, education, workforce competences technology, macro-level development, micro-level development
Cross-validation of methods for the quantitative determination of phenazepam and its active metabolite in human blood plasma at various extractions
Authors: Platova A. I. , Kuzmin I. I. , Ivaschenko D. V. , Miroshnichenko I. I.
Published: October 2024

Introduction. In conducting of therapeutic drug monitoring (TDM), often such situation arises where the drug concentration has measured by different methods or in different laboratories. To combine and analyze the data obtained with different methods, it is necessary to perform cross-validation procedure. Insufficient attention is paid to the statistical approaches used for this purpose.

Aim. Performing cross-validation of different analytical methods for the quantitative determination of phenazepam (PHEN) and 3-hydroxyphenazepam (3-OH-PHEN) using the Bland – Altman analysis.

Materials and methods. PHEN and 3-OH-PHEN concentrations in the blood plasma of patients (n = 100) with alcohol withdrawal syndrome were measured using high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The quantification of both analytes in each sample was measure twice by two different methods: solid phase extraction (SPE) and supported liquid extraction (SLE). Both methods have been fully validated before the experiment began. Cross-validation was performed at the end of the experiment using data from study samples. The Bland – Altman analysis was used to evaluate accuracy and precision. Deming regression was also used to identify a systematic error between measurement results.

Results and discussion. The regression equations have been obtained between concentrations both analytes measured by different sample preparation methods. 95 % confidence intervals (CI) of the regression coefficients of both equations included one, and 95 % CI of the intercepts included zero. 95 % CI of the geometric mean of the individual SLE/SPE ratios was within the acceptable range (0.87; 1.15). These results confirm the absence of the influence of quantitative methods on the measurement of both analytes concentration. 66.7 % CI of the percent difference between two measurements was within acceptable limits (–0.2; 0.2), not exceeding 20 % of the range of their mean value. This confirms the acceptable precision between the methods. The estimated CIs were displayed in the Bland – Altman plots.

Conclusion. The statistical approaches used in the work have confirmed the reproducibility of the results of different sample preparation methods. In addition to cross-validation, the statistical algorithm from this paper using Bland – Altman analysis can be successfully employed to assess accuracy and precision during bioanalytical method validation and evaluation of the acceptance of analytical runs, as well as to determine the level of reproducibility of incurred samples.
Radiological Signs: The Key to Clinical Diagnosis
Authors:   Pediatric Neuroradiologist, Deputy Regional Medical Director Northern Border, Poplar Medical Laboratory, Mexico, López Gerardo Villegas , Correa Viridiana Perez ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Covarrubias Nabile Andrea ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Gonzalez Ma del Pilar ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Cárdenas Luz Gisela ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Zapata Ana Luisa ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Torres Rolando ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Garay Juan Alberto ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Zuluaga Jose Álvaro ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Miranda Sergio Ernesto ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Mendoza Froylán ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Beltran Alberto Conrado ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Ramirez Jorge Luis ,   Radiologist Physician, Chopo Medical Laboratory, Mexico, Zuñiga Jorge Alexis ,   Radiologist Physician, Chopo Medical Laboratory, Mexico
Published: October 2024

Since the first years of university medical education, it was difficult to remember the names of diseases, eponyms, pathways, gyral tracts, convolutions and other neuroanatomical structures. Semiology is the branch of medicine that studies, interprets and arranges the signs and symptoms of diseases in order to arrive at a diagnosis. Radiological semiology is the art and science of diagnosis by means of images, thanks to which we can reach a presumptive diagnosis. In radiology, to perform a correct semiology, it is necessary to have knowledge of different areas such as anatomy, physiology, pathology, if the patient has been previously treated or if the study is performed after a surgical approach.
From Newton's First Law to the Motion of Celestial Bodies
Authors:   Weifang Engineering Vocational College (Weifang Educational College), Qingzhou City, Shandong Weifang, 262500-China., Wang Xiao En ,   Zhaoqing KAIST battery material Co., Ltd. Gaoyao District of Zhaoqing City, Guangdong Province, 526100-China.
Published: October 2024

Newton's original work "Principles" was written in Latin. An English version translated two years after his death changed the first law from "in directum" to "in a right line." Later generations think that only static or uniform straight line motion is inertia, while excluding rotational motion. This article proposes that the gravitational potential energy of a planet's revolution is equal to its centrifugal kinetic energy (mυ2). The work done by an object is a process quantity, but kinetic energy is a state variable that can be divided into instantaneous kinetic energy and average kinetic energy. Uniform motion does not do work, and instantaneous kinetic energy in variable speed motion does not also do work, only the average kinetic energy of variable speed motion does work. Only the energy between work and the average kinetic energy of variable speed motion can be converted into each other. We have clarified the relationship between work and kinetic energy, completed the transition of the kinetic energy formula at low and high speeds, achieved the unification of the kinetic energy formula and the mass energy relationship formula, and explained the √2 factor in the escape velocity..
Low-pressure Pulmonary Recruitment Maneuver to Decrease Post-laparoscopic Shoulder Pain in Gynecologic Surgery: A Double-blind Randomized Placebo Controlled Trial
Authors:   Department of Obstetrics and Gynecology, Rajavithi Hospital, Bangkok, Thailand., Yodruangwong Anon , Chirasophon Seksit ,   Department of Obstetrics and Gynecology, Rajavithi Hospital, Bangkok, Thailand.,   College of Medicine, Rangsit University, Bangkok, Thailand., Tirasuntornwong Viranut ,   Department of Anesthesiology, Rajavithi Hospital, Bangkok, Thailand.,   College of Medicine, Rangsit University, Bangkok, Thailand.
Published: October 2024

Objective: To evaluate the efficacy of minimum optimal pressure (30 and 40 cmH2 O) of pulmonary recruitment maneuver (PRM) for reducing post-laparoscopic shoulder pain (PLSP). Methods: Women who were scheduled for laparoscopic gynecologic surgery during October 2020 to June 2021 were enrolled and randomly assigned to three groups: PRM 30 cmH2 O (30-PRM) group, PRM 40 cmH2 O (40-PRM) group and control group. All participants were placed in the Trendelenburg position and compressed abdomen to eradicate gas. PLSP scores were assessed by using a visual analog scale (VAS). Results: Total of 80 women were included and randomized to 30-PRM group (N = 28), 40-PRM group (N = 26) and control group (N = 26).The PLSP scores at 12-hour after surgery in 40-PRM group were significantly lower than the control group (VAS 0 = 57.7%, VAS 1-3 = 19.2% and VAS ≥ 4 = 23.1% in 40-PRM group vs VAS 0 =19.2%, VAS 1-3 = 26.9% and VAS ≥ 4 = 53.9% in control group, P = 0.018), while no significant difference of PLSP between 30-PRM and control groups (P = 0.256). Other variables, such as PLSP at 24 and 48 hrs., post-operative surgical pain, nausea and vomiting, vital signs and residual gas in abdominal cavity at 24-hour were similar among three groups. Conclusions: PRM with pressure 40 cmH2 O significantly decreases PLSP at 12 hours. This procedure is feasible and safe. Using the PRM with pressure 40 cmH2 O may be applied at the end of laparoscopic procedure
Designing with the Goal in Mind: How Public Charter Schools Are Facilitating a Comprehensive College-going Culture
Authors: Landeros, Ed.D. Margarita
Published: October 2024

Charter schools were approved to exist in the U.S. as an alternative form of public education to offer solutions to the challenges of traditional public schools. Learnings from charter schools continue to live in our texts, and minimal efforts have been made to inventory the takeaways from this setting. By examining how seven school counselors representing six Charter Management Organization (CMOs) high schools in Los Angeles have used their school’s autonomy to implement a comprehensive college-for-all-all model, this study offers implications for the counselor role and how mission-driven public schools offer comprehensive college counseling. Participants described the goals of the counselor role, systematic components, and supporting factors that allow for a college-for-all model. The study also discusses implications for educational leaders and policymakers on how role clarity and the school mission can influence school outcomes for college acceptance and enrollment.