bluuebunny/crossref_metadata_2025 huggingface dataset:
God Was Never there God and the Shoah in the Netflix Series Jaguar
Authors: Bosman Frank G.
Published: September 2023

On September 22, 2021, the Spanish series Jaguar was released on Netflix. Its six episodes of season one (a second season is yet to be confirmed) focus on a fictional band of Nazi-hunters in Spain, somewhere in the 1960s, calling themselves “Jaguars” (hence the series’ title). All but one Jaguar member are survivors of several German concentration camps, and dedicate their lives to bring Nazi war criminals, who are spending their days in luxury under the protection of the Franco regime in Spain, to justice. One of the Jaguars is Marsé (Francesc Garrido), a bearded man in his forties, and the team’s dedicated driver. Step by step, the viewer of Jaguar learns his background story: ordained a Roman Catholic priest, he renounced his faith after having witnessed and experienced the horrors of the Nazi regime in Dachau concentration camp. Marsé still struggles with his former faith and occasionally shares his theological insights with his teammates, especially with the series’ protagonist Isabel Garrido.
Effect of Coating on Physico-Chemical Characteristics of Puffed Wheat Grains
Authors: Konkubaeva Nurzat , Juhnevica-Radenkova Karina , Radenkovs Vitalijs , Galoburda Ruta
Published: September 2023

Durum wheat (Triticum turgidum) is used for the production of various ready-to-eat products such as breakfast cereals, puffed grains, and extruded products. Technological processes of grain processing and the addition of different ingredients cause changes in the physical and chemical properties of the product, which give puffed grains a unique porous structure and change their nutritional value. This study aimed to evaluate the effect of coating on the physico-chemical characteristics of puffed wheat grains depending on the coating material. The study revealed that the application of coating increased dry matter and thousand-kernel weight (TKW). Water activity decreased in puffed grain without coating (BZ), and puffed grain with whey powder (MC) compared to wheat grain. The reduction in the moisture content increased the crispiness of product. Application of coating led to a decrease in the hardness of both MC and puffed wheat grain with vanillin and sugar (BV). Applying additives to the product’s surface led to a decrease in the water absorption index (WAI). The water solubility index (WSI) increased in the MC and BV samples. Samples BZ, BV and MC had higher L* (lightness) values than wheat grains because the puffing process expanded the cells, confirmed by scanning electron microscopy, and caused starch gelatinisation. The a* (redness) value of wheat was greater than that of BZ, BV and MC, which may be due to the partial removal of the outer layer of wheat grains. The milled samples of BZ, BV and MC were slightly darker, having lower L* values, compared to unprocessed wheat grain.
Hypereosinophilic syndrome presenting as eosinophilic gastroenteritis exacerbated by clopidogrel bisulphate
Authors: Horino Taro , Ohnishi Hiroshi , Komori Masahiro , Terada Yoshio
Published: September 2023

Clopidogrel is a widely prescribed prodrug with antithrombotic activity that functions by irreversibly inhibiting the P2Y12 receptors on platelets; nevertheless, drug-induced eosinophilia from this drug is rarely reported. An 81-year-old man was diagnosed with cerebral infarction 2 months earlier and was admitted to our hospital with rash, fever, wheezing, and stomach discomfort after being initiated with clopidogrel treatment. Based on his medical history, chest CT, and gastroscopy, we diagnosed him with clopidogrel-induced hypereosinophilic syndrome. After discontinuation of clopidogrel, the eosinophilia and symptoms improved. In cases of drug-induced eosinophilia, it is important to obtain a detailed medical history.
Symbolic Mythology: The Portrayal of Gender Fluidity in Kae Tempest Selected Poems
Authors: Okasunu I Gusti Ayu Sundari , Darma Putra Darma Putra
Published: September 2023

Myth in literary works tends to be used as a traditional story which typically aims to represent and explain certain natural phenomenon. One of those phenomenon are the existence of multi-binary or even non-binary gender which at first known as mythological story of Tiresias that become a real social issue recently. Related to myth, this article is aimed to identify and elaborate the term neutral and gender fluidity correlates to the mythology of Tiresias from Oedipus in the account of hybrid sign by Pierce. Tiresias representing the fluidity term of gender which in the written poems by Tempest’s selected works has symbolical meaning. The data was taken from selected poems in Kae Tempest anthological poetry and collected using proposed sampling technique. The criterion of the sampling is the use of mythological symbol. As a result, the research found there are several symbols, icons, and indexes used to represent neutral gender into Tiresias such as snakes, name of Tiresias, sex, body, and prophet. More than that, some figurative language also used to strengthen the implication of Tiresias implicitly in poem such as like a lady. Besides, typography also found to represent fluid identity such as ones and yous. Thus, this article is contributed to the embodiment of hybrid sign concept applied in literary analysis poetry. Moreover, it is also contributed to the development of gender theory which enlarge the knowledge about fluidity and neutral term of gender.
Makanan Jepang, Identitas, Kuasa dalam Novel Sasamakura Karya Saiichi Maruya
Authors: Purba Esther Risma
Published: September 2023

Diskursus identitas Yamato damashii ‘Japanese Spirit’ atau ‘Jiwa Jepang’ mengonstruksi pengetahuan mengenai “orang Jepang”, “budaya Jepang” dan “nasionalisme”. Penelitian ini berfokus pada tokoh utama, Hamada dan dilakukan dengan menggunakan paradigma kritis, yakni membongkar aspek kuasa yang mengkonstruksi identitas Jepang lewat makanan dengan menggunakan teori identitas Stuart Hall dan teori relasi kuasa Foucault. Melalui reintegrasi dan penciptaan kembali, makanan yang awalnya milik asing, dilepas dari identitas awalnya untuk menjadi masakan yang disebut masakan Jepang. Keberadaan pihak lain, yakni Barat melalui makanan menjadi pihak yang dianggap berbeda sehingga diposisikan berhadapan dengan Jepang. Apa yang disebut sebagai nihon ry?ri atau washoku menduduki posisi yang lebih istimewa karena muatan sejarah peradaban makanan yang diklaim memiliki sejarah yang panjang, asli, dan tidak bercampur dengan budaya lain yang dianggap liyan atau inferior. Oleh karena itu, orang Jepang yang dianggap memiliki identitas kejepangan, dianggap merepresentasikan Yamato damashii ‘Jiwa Jepang’ apabila memilih memakan nihon ry?ri dan makan dengan cara atau etiket yang telah ditetapkan.
Representasi Peristiwa Sejarah Genkou yang Terdapat dalam Video Game Ghost of Tsushima
Authors: Chen Erica , Anggraeny Renny
Published: September 2023

Artikel ini membahas mengenai representasi peristiwa sejarah genkou yang terdapat dalam video game berjudul Ghost of Tsushima hasil kembangan Sucker Punch Productions. Metode yang digunakan dalam artikel ini ialah metode simak dan catat dengan pendekatan deskriptif kualitatif. Teori yang digunakan dalam artikel ini adalah teori new historicism yang dikemukakan oleh Greenblatt. Berdasarkan hasil penelitian, video game tersebut merepresentasikan peristiwa sejarah genkou ke dalam delapan peristiwa. Kedelapan peristiwa ini tidak sepenuhnya sesuai dengan peristiwa yang terjadi dalam fakta sejarah genkou. Oleh karena itu, peristiwa-peristiwa tersebut terbagi menjadi tiga kategori yang terdiri dari peristiwa yang sesuai, peristiwa yang mirip, dan peristiwa yang berbeda. Peristiwa yang paling sesuai dalam merepresentasikan peristiwa sejarah genkou ialah pertahanan 80 orang samurai yang dipimpin oleh Shimura. Delapan puluh orang samurai melawan ribuan pasukan Mongol merupakan kejadian yang khas dari sejarah genkou. Detail kecil mengenai pemimpin dari kedelapan puluh samurai yang merupakan seorang jito di pulau Tsushima juga direpresentasikan dalam game.
Penggunaan Campur Kode Guru dalam Pembelajaran Bahasa Jepang Kelas XI IBB di SMAS LAB UNDIKSHA
Authors: Alit Mandala Ayu Kris Utari Dewi , Dwipayanti Ni Kadek , Tiara Karunia Dewi Putu , Dewi Merlyna Putu
Published: September 2023

The purpose of the study is to examine how Japanese language instructors used mixed codes in Japanese class XI IBB at the Undiksha Laboratory Private High School. Non-participation observation techniques were used in this study as qualitative descriptive methodologies. This study focused on a Japanese instructor at SMAS Laboratory Undiksha Class XI Language. The utterances made by Japanese teachers while engaging students in learning activities served as the study's data source. According to the findings of this investigation, Japanese professors at SMA Private Laboratory Undiksha sometimes mix codes externally. The research findings are presented in the form of a conversation between the teacher and the students, followed by a descriptive technique.
Struktur Pembentuk Nomina Tempat dalam Bahasa Jepang pada Novel Berjudul Fune wo Amu Karya Shion Miura
Authors: Pamungkas Aji Satrio , Widya Purnawati Ketut , Rauh Artana I Nyoman
Published: September 2023

"The Structure of Forming Nouns of Place in Japanese in a Novel Entitled Fune Wo Amu by Shion Miura" is the title of this study. The purpose of this research is to learn more about the structure of the formation of place nouns in Japanese which is found in a novel entitled Fune Wo Amu by Shion Miura. Descriptive qualitative method is the method used in this research. Japanese Morphological Theory and the Semantic Theory by Tsujimura (2014) are the theory used in this research. Based on the result of this research, it can be concluded that noun place marker suffixes can be attached to bound morphemes, nouns, verbal nouns, and root verbs (ren'y?kei). The kango type of word is the type of word that is most often attached by place marking suffixes in Japanese. In addition, when compared to other types of place noun-forming suffixes such as ~? (-ba, -jo?), ~? (-dokoro, -sho, -jo), ~? (-kan), ~? (-ya), ~? (-chi), ~? (-ten), ~? (-in), and ~? (-do?), the suffix ~? (-shitsu) produces the most place nouns.
Nodulation Potential of Annual Sweet Lupins (Lupinus spp. L.) and its Effect on Soil Nitrogen and Phosphorus in Acidic Soils of Western Amhara, Ethiopia
Authors: Yeheyis Likawent , Feyisa Tesfaye , Mekonnen Wondmeneh , Nelson Matthew , Mcnaughton David , Yadelew Zelalem , Sanders Heather
Published: September 2023

In Ethiopia livestock feed shortage and soil acidity are serious problems. In recent years sweet lupins (white and blue species) were introduced as multipurpose crops in the country. However, there is no information about their nodulation potential. This study was conducted to evaluate nodulation potential of these sweet lupins and their effect on nitrogen (N) and phosphorous (P) content of the soil. Seven lupin varieties were evaluated using factorial arrangement (seven varieties * two inoculations) in a randomized complete block design in two locations for two years. The result showed that effect of inoculation and location was not significant (P > 0.05) on biomass, seed, nodule number and soil parameters. While the effect of variety was significant (P < 0.05) on nodule parameters. Its effect on dry biomass and seed yields was also significant in either of the years. Variety and year had no effect on soil N and P contents. In the first year, blue sweet lupin entries had the highest nodule number per plant, 222 nodules.  In the second year similar nodulation performance was observed among species and varieties. Soil N and P were not affected by varieties and inoculation. In addition to their yield advantage, compared to the sweet white entries, blue sweet lupin varieties had high potential in nodulation. Therefore, these introduced sweet blue lupins can be used as multipurpose crops in acidic soils of Ethiopia.
The Problem of Water Scarcity in Central Asia: the Factor of Afghanistan
Authors: Zhiltsov S. S.
Published: September 2023

The article deals with the problem of water scarcity in the countries of Central Asia. Despite their efforts, the lack of water availability continues to persist. This increases tension in the inter-state relations in the region, as in recent years the countries increasingly face a shortage of water. Recently, Afghanistan has begun to influence the distribution of water resources in the region. Its actions are aimed at increasing abstraction of water resources from transboundary rivers of Central Asia. At the same time, Afghanistan has a right to act in this way. However, given the increasing shortage of water resources, Afghanistan’s policy may lead to new conflicts and exacerbation of relations with the Central Asian states.
China’s energy transition: preliminary results and challenges for the future
Authors: Xialan L.
Published: September 2023

The article is devoted to the study of China’s energy transition policy and the prospects for its implementation. As the world’s second largest economy, the People’s Republic of China has become an important part of the global energy market in recent years. In the process of industrialization and economic growth, the Chinese economy plays an important and positive role in maintaining the world’s energy security. In connection with the gradual slowdown in the growth of the Chinese economy, the full implementation of the Paris Agreement, as well as the transformation and modernization of the global energy structure, the Chinese side proposed a new strategy for energy transition and energy security. In 2020, China announced a desire to reduce carbon emissions and achieve carbon neutrality. Despite the fact that China’s own coal dominates in the structure of China’s energy balance, the emphasis is on identifying the role of oil and gas in the modernization of the energy system. The features of China’s energy production and consumption structure are emphasized, in which natural gas can become an auxiliary and transitional energy source during its transformation of the energy system. The article discusses the main documents that define the energy transition. The preliminary results of China’s implementation of the new energy policy have been summed up. It is concluded that energy saving and efficiency improvement are the primary objectives of China’s modern energy strategy, as well as important measures to reduce carbon dioxide emissions.
A masquerade of recurrent anaphylaxis
Authors: Gabreski Lauren N. , Schuldt Meredith M. , Adams Karla E.
Published: September 2023

Background: We present a case of a 37 year old man with a history of human immunodeficiency virus, latent syphilis, anxiety, posttraumatic stress disorder. attention deficit/hyperactivity disorder, multiple drug intolerance syndrome who presented with concerns of recurrent
episodes of rash and respiratory symptoms with questionable “anaphylaxis” episodes without clear etiology or known trigger. Methods: To evaluate some of the potential causes of recurrent anaphylaxis in our patient. Further evaluation through laboratory analysis
and ultimately direct visualization of the patient’s vocal cords by laryngoscopy assisted in the final diagnosis. Results: Inappropriate adduction of the vocal cords was observed during an acute reaction. Conclusion: The patient’s presentation
was consistent with inducible laryngeal obstruction and highlights the importance of confirming a suspected diagnosis of anaphylaxis and keeping a broad differential when establishing an etiology.
ASPECTS OF THE REGULATION OF ARTIFICIAL INTELLIGENCE
Authors: Kerekes László
Published: September 2023

Artificial intelligence is increasingly influential in contemporary society. Isaac Asimov's seminal work, “I, Robot”, introduced the foundational robotic laws that have inspired both fictional and real-world discussions. This study examines how Asimov's "laws" are reflected in the legislation of various nations and international organizations, and explores the justification for their inclusion in legal literature and dogmatics. The research focuses on issues related to the regulation of artificial intelligence, including the demarcation of robotics and relevant governmental regulations. Employing descriptive and comparative methods, the study is structured as follows: The first chapter addresses the ontological characteristics of artificial intelligence; the second chapter reviews the regulatory approaches of various states; and the third chapter explores the implications for potential perpetrators of AI-related offenses. Given the continuous advancement of technology, which enhances production efficiency, drives business innovation, and offers recreational benefits, the necessity for legal regulation of emerging pervasive technologies is evident. The findings suggest that the current EU legislation is designed to guide future regulatory developments and has incorporated significant aspects of Asimov's principles into its framework.
Transtorno de ansiedade generalizada
Authors: Mochcovitch Marina Dyskant , Nardi Antonio Egidio
Published: September 2023

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Violência nas escolas
Authors: Rocha Simone Secco da , Guimarães Katia Burle dos Santos , Moraes César de
Published: September 2023

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Effect of Steroids and Black Seed Oil on Hydrogen PeroxideConcentration and pH of Expired Breath Condensate inAsthmatic Patients
Authors: MoHamed Al-Samarai Abdul Ghani , Hamed Al Obaidy Amina
Published: September 2023

Asthma is a chronic inflammatory disease of airway, with increased worldwide prevalence. This study was conducted the for evaluation the effect of different treatment regimens on expired breath condensate hydrogen peroxide concentration and pH. Patients and methods: Thirty two patients ( 17 male, 15 female), with asthma were examined during exacerbation. Asthma was diagnosed according to American Thoracic Society Criteria. The pH level was increased significantly following treatment with prednisolone. In addition, expired breath condensate hydrogen peroxide in patients with acute attack reduced significantly (P<0.0001) following treatment with prednisolone. Black seed oil treatment reduced expired breath condensate H202 concentration from 1.29 µM (95% CI, 1.08-1.50) as baseline values to 0.56 µM (95% CI, 0.45-0.67) following treatment. Furthermore, pH of expired breath condensate increased from 5.54 (95% CI, 4.97-6.11) at baseline to 6.8 (95% CI, 6.28-7.32) following treatment course of back seed oil. Thus the treatment course of black seed oil significantly reduced expired breath condensate H202 concentration (P< 0.0001) and increased exhaled pH (P< 0.0 l ). For the groups that were treated with oral prednisolone or black seed oil, there were a highly significant inverse correlation among expired breath condensate H202 with pH, Exhaled H202 with FEVl predicted percent and positive correlation for exhaled pH with FEY 1 predicted percent. Steroids and back seed are with activity to reduce expired breath condensate hydrogen peroxide concentration and pH. This may indicate that they may be used for asthma treatment.
Effects of Obesity on Blood Pressure Among Adult Malesand Females in Tikrit City - Sep-Dec, 2008
Authors: Q Hamdi Anas , K Asaad Nahla , K Asaad Asef
Published: September 2023

Obesity is an independent risk factor for cardiovascular disease. Clinical studies have shown that body weight reduction decreases blood pressure. The aim of this study was to illustrate the relationship between obesity and blood pressure among adult males and females in Tikrit city. A case series study among the population aged over 25, (400 individuals, 200 males and 200 females) in Tikrit city. Sample was collected from September till December 2008. The blood pressure of subjects was measured in three occasions one month apart via mercurial sphygmomanometer by well trained personnel to those patients attending to Medicine outpatient of Tikrit Teaching Hospital. Mean systolic blood pressure (SBP) was significantly lower in all groups (P<0.005) in non-obese compared with obese patients. This positive relation well indicates the higher the BMI, the more elevated SBP. However, reduction of diastolic blood pressure (DBP) mean was significant only in men and women who were under treatment with antihypeftensive drugs (P<0.05). In all hypertensive groups and in healthy subjects, there was an increase in body mass index (BMI). This increase was more notable in hyper-tensive groups, compared with healthy individuals. The prevalence of obesity in hypertensive patients was higher than that of the healthy group.
Synthesis of some new ,3-oxazepine derivativesand evaluation of antibacterial activitv
Authors: H.A. Al-Somaidaie Gazwan , Y. Majeed Ismeel , K. Jassim Ibtisam
Published: September 2023

This paper contained the synthesis of some new derivatives of 1,2,4-ttazole ring from the reactions of 3-amino 1,2,4-triazole derivatives (I) with different substituted benzaldehyde (in absolute .ethanol with present glacial acetic acid as catalyst) to prepare Schiff bases (IIa-c). The prepared new Schiff bases (IIa-c) reacted with maleic anhydride or 2-nitro phthalic anhydride in dry benzene to give oxazepines compounds (IIIa-e) (7-membered ring). The synthesized compounds were elucidated by some spectroscopy methods (IR ,UV and Elemental analysis (C.H.N)) besides the TLC was used to check the products. Tire biological activities of some prepared compounds (IIa, IIIa-e) were also studied asainst four different kinds of bacteria.
Study of Malnutirtion in Children below 5 years in SulaimanyaCity
Authors: A. hadi Al-saady Ali
Published: September 2023

Study of malnutrition (underweight & overweight) in children under 5 years in that area & its relation to different variables (Age, Sex, Type of milk feeding, Time of introduction of complementary feeding, maternal education and previous hospital admission). The sample was collected randomly from 4 primary health care centers in Sulaimany city between (July - 2005) to (January - 2006). The total no. of children suweyed were 456, 256 (65.I o/o) were (male), 200 (43.9%) were (female). Stunting, wasting & underweight were reported in 6.3Yo , 6.lyo ,lI.Iyo respectively ,while rate of obesity and overweight werc 7.6Yo ,3.syo respectively. A statistically significant association was noted between various forms of malnutrition and age implying an increase prevalence of stunting after the 2nd year of life and increase in prevalence of underweight during the I't y.ut of lif", while obesity and overweight clustered in the age range (4-5 yrs). Malnutrition also have high association with level of maternal education , higher prevalence of malnutrition( stunting ,wasting ,underweight) in illiterate mothers & lowest in highly educated ,while prevalence of over nutrition (obesity & overweight) were more in highly educated mothers and least in illiterate ones. The nutritional status of children under 5 years in Sulaimany city seems to be satisfactory except for moderately high prevalence of wasting which requires further support to the child health through continuing the nutritional support offered to that area and promotion of maternal education regarding child health and nutrition.
Referred otalgia:evaluation of causes
Authors: Ali Fleah Khalid
Published: September 2023

Otalgia is the sensation of pain in the car, while referred otalgia Is pam felt in the ear but originating from non-otological source Lar pain is a diagnostic problem when examination of the ear shows no pathology. A prospective study was conducted in EN.T - private clinics in Kirkuk city from October 2007 to December 2008. Age , sex and causes of referred ofalgia were noted, During the study period 210 patients were evaluated , out of 210 patients 122 male "58%" and 88 females "42%", Tonsillitis,pharyngitis and post tonsillectomy were the commonest cause"S1 4%" Three patients had malignancy of upper aerodigestive tract and referred otalgia was one of its main symptoms. Referred ear pain is more commonly caused by tonsillitis , pharyngitis

but it may be first symplom of head and neck malignancy,
Mechanisms Contributing to the Dynamic Stability of a Flexible Subscale Rocket Nozzle
Authors: Jack Sebastian , Oschwald Michael , Eggers Thino
Published: September 2023

Forced motion simulations of an overexpanded subscale rocket nozzle were performed to investigate the transient mechanisms that lead to self-exciting fluid–structure interaction as observed in preceded studies. The pressure response to the deformation could be separated into two regions upstream and downstream the flow separation position. Within these regions the transient part of the pressure was analyzed using fast Fourier transform based on the method of generalized aerodynamic forces. The amplitude spectrum and phase shift distribution of the pressure response could be explained by superposition of three independently acting mechanisms: the inclination effect, the existence of a moving axial pressure wave, and intrinsic oscillations caused by the turbulence created by the strong shock system. Simplified simulation setups using a bent flat plate and a detailed unsteady simulation of the flow in the undeformed nozzle were analyzed to validate these assumptions.
Semi-Continuous Descent Operation: A Fuel-Efficient Interval Management Algorithm
Authors: Wada Shinji , Ishii Minami , Inoue Masaki , Toratani Daichi
Published: September 2023

This paper presents a fuel-efficient interval management algorithm called semi-continuous descent operation (semi-CDO) to support air traffic controllers in issuing altitude and velocity instructions to arriving aircraft to ensure proper separation. The control logic of semi-CDO is stated as an optimization problem of minimizing the fuel consumption of the descending trajectory based on the prediction model under the separation constraints. Numerical experiments simulating the arrival traffic at Kansai International Airport in Japan were performed to verify the effectiveness of the proposed algorithm. The results showed that semi-CDO achieves the fuel-efficient descent for multiple arrival aircraft while maintaining proper separation between them.
Benchmarking Deep Learning Models on Myriad and Snapdragon Processors for Space Applications
Authors: Dunkel Emily R. , Swope Jason , Candela Alberto , West Lauren , Chien Steve A. , Towfic Zaid , Buckley Léonie , Romero-Cañas Juan , Espinosa-Aranda Jose Luis , Hervas-Martin Elena , Fernandez Mark R.
Published: September 2023

Future space missions can benefit from processing imagery on board to detect science events, create insights, and respond autonomously. One of the challenges to this mission concept is that traditional space flight computing has limited capabilities because it is derived from much older computing to ensure reliable performance in the extreme environments of space: particularly radiation. Modern commercial-off-the-shelf processors, such as the Movidius Myriad X and the Qualcomm Snapdragon, provide significant improvements in small size, weight, and power packaging; and they offer direct hardware acceleration for deep neural networks, although these processors are not radiation hardened. We deploy neural network models on these processors hosted by Hewlett Packard Enterprise’s Spaceborne Computer-2 on board the International Space Station (ISS). We find that the Myriad and Snapdragon digital signal processors (DSP)/artificial intelligence processors (AIP) provide speed improvement over the Snapdragon CPU in all cases except single-pixel networks (typically greater than 10 times for DSP/AIP). In addition, the discrepancy introduced through quantization and porting of our Jet Propulsion Laboratory models was usually quite low (less than 5%). Models were run multiple times, and memory checkers were deployed to test for radiation effects. To date, we have found no difference in output between ground and ISS runs, and no memory checker errors.
Modeling Unsteady Surface Pressure Autospectra for Turbulent Boundary-Layer Flow over Small Dense Roughness
Authors: Catlett M. Ryan , Bryan B. Skyler , Chang Natasha , Hemingway Hugh , Anderson Jason M.
Published: September 2023

This work concentrates on analyzing and modeling the unsteady surface pressure autospectra beneath zero-pressure gradient, turbulent boundary-layer flowfields with variably rough flow surfaces. These surface conditions are qualitatively described as being for small, dense, rigid, spatially homogeneous roughness topologies, along with corresponding quantitative parameters. Turbulent boundary-layer velocity and unsteady surface pressure data from a new wind tunnel test with multiple surface conditions are analyzed in conjunction with the compiled results from five, distinct, additional references. These compiled results are utilized to develop and propose a new empirical model for the unsteady surface pressure autospectra for a range of variably rough surfaces. This new modeling framework is approached as an extension of the Goody model, which pertains to smooth-wall flows. The variable character of the newly proposed model is controlled by parameters based on viscous scaling of the effective roughness height and friction velocity such that the surface pressure model inputs are based on readily available mean properties of the turbulent boundary-layer flowfield. For the data utilized in this analysis the approximate values of viscous scaled effective roughness height range between approximately 100 and 2000. Finally, this newly proposed model is used to compare to the unsteady surface pressure data of two additional and separate experimental references for rough-wall flows, yielding further positive comparisons as well as isolated examples of the sensitivity of analysis and modeling to the determined friction velocity for a flow configuration.
Probing the Chemical "Reactome" with High Throughput Experimentation Data
Authors: King-Smith Emma , Berritt Simon , Bernier Louise , Hou Xinjun , Klug-McLeod Jacquelyn , Mustakis Jason , Sach Neal , Tucker Joseph , Yang Qingyi , Howard Roger , Lee Alpha
Published: September 2023

High-throughput experimentation (HTE) has the potential to improve our understanding of organic chemistry by systematically interrogating reactivity across diverse chemical spaces. Notable bottlenecks include few publicly available large-scale datasets and the need for facile interpretation of these data's hidden chemical insights. Herein we report the development of a High Throughput Experimentation Analyzer (HiTEA), a robust and statistically rigorous framework which is applicable to any HTE dataset regardless of size, scope, or target reaction outcome. We improve the HTE data landscape with the disclosure of 39,000+ previously proprietary HTE reactions. HiTEA is validated on this dataset, showcasing the elucidation of hidden relationships between reaction components and outcomes as well as highlighting reaction space that necessitates further investigation.
Molecular Additives Improve Selectivity of CO2 Photoelectrochemical Reduction over Gold Nanoparticles on Gallium Nitride
Authors: Aitbekova Aisulu , Watkins Nicholas , Richter Matthias , Jahelka Phillip , Peters Jonas , Agapie Theodor , Atwater Harry
Published: September 2023

Photoelectrochemical CO2 reduction (CO2R) is an appealing solution to convert carbon dioxide into higher-value products. However, CO2R in aqueous electrolytes suffers from poor selectivity due to the competitive hydrogen evolution reaction dominant on semiconductor surfaces in aqueous electrolytes. We demonstrate that functionalizing gold/p-type gallium nitride devices with a film derived from diphenyliodonium triflate suppresses hydrogen generation from 90% to 18%. As a result, we observe an increase in the Faradaic efficiency and partial current density for carbon monoxide by 50% and 3x, respectively. Furthermore, we demonstrate through optical absorption measurements that the molecular film employed herein, regardless of thickness, does not affect the photocathode’s light absorption and, therefore, photocurrent. Together, this study provides a rigorous platform to elucidate catalytic structure-property relationships to enable engineering of active, stable, and selective materials for photoelectrochemical CO2 reduction.
Red light activatable chemo-optogenetic dimerization regulates cell apoptosis
Authors: Chen Xi , Zhou Yue , Zhou Chengjian , Zhou Ziqi , Zhang Yan
Published: September 2023

We report a non-phototoxic and non-photobleaching chemo-optogenetic dimerizer that effectively regulates protein-protein proximity inside living cells using far-red light. This system introduced the first deep-red/NIR light photoactivatable chemical inducer of proximity (pCIP) or dimerization (pCID), called dmBODIPY-ABA, or dmBODIPY caged abscisic acid (ABA). dmBODIPY-ABA dimerizer shows an anti-Stokes feature that further shifts the absorption to NIR direction and it displays a strong hyperchromic shift compared to the dmBODIPY photocage. By utilizing this non-invasive and biocompatible system, we successfully controlled apoptosis by targeting the key apoptotic factor, Bax, to the outer membrane of mitochondria, thus opening a window for precise control of programmed cancer cell death using deep-red light.
Synthesis of small PAMAM-dendrimers with Well-defined Structural Diversity.
Authors: Leth Mejlsøe Søren , Fabritius Petersen Johannes , Christensen Jørn Bolstad
Published: September 2023

PAMAM-dendrimers are the best investigated family of dendrimers, but methods for synthesizing PAMAM-dendrimers with well-defined heterogeneously substituted surfaces are lacking. In this paper, we present a general scalable, synthetic scheme that allows control over the position and number of different surface groups.
A layered organic cathode for high-energy, fast-charging, and long-lasting Li-ion batteries
Authors: Chen Tianyang , Banda Harish , Wang Jiande , Oppenheim Julius , Franceschi Alessandro , Dinca Mircea
Published: September 2023

Eliminating the use of critical metals in cathode materials can accelerate global adoption of rechargeable Lithium-ion batteries. Organic cathode materials, derived entirely from earth abundant elements, are in principle ideal alternatives, but have not yet challenged inorganic cathodes due to poor conductivity, low practical storage capacity, or poor cyclability. Here, we describe a layered organic electrode material whose high electrical conductivity, high storage capacity, and complete insolubility enable reversible intercalation of Li+ ions, allowing it to compete at the electrode level, in all relevant metrics, with inorganic-based lithium-ion battery cathodes. Our optimized cathode stores 306 mAh g–1cathode, delivers an energy density of 765 Wh kg–1cathode, higher than most cobalt-based cathodes, and can charge-discharge in as little as six minutes. These results demonstrate operational competitiveness of sustainable organic electrode materials in practical batteries.
DiffSeqMol: A Non-Autoregressive Diffusion-Based Approach for Molecular Sequence Generation and Optimization
Authors: Wang Zixu , chen yangyang , Ye Xiucai
Published: September 2023

The application of deep generative models for molecular discovery has witnessed a significant surge in recent years. Currently, the field of molecular generation and molecular optimization is predominantly governed by autoregressive models regardless of how molecular data is represented. However, an emerging paradigm in the generation domain is diffusion models, which treat data non-autoregressively and has achieved significant breakthroughs in areas such as image generation. The potential and capability of diffusion models in molecular generation and optimization tasks remain largely unexplored. In order to investigate the potential applicability of diffusion models in the domain of molecular exploration, we proposed DiffSeqMol, a molecular sequence generation model, underpinned by diffusion process. DiffSeqMol distinguishes itself from traditional autoregressive methods by its capacity to draw samples from random noise and direct generating the entire molecule. Through experiment evaluations, we demonstrated that DiffSeqMol can achieve, even surpass, the performance of established state-of-the-art models on unconditional generation tasks and molecular optimization tasks.
Investigating the Interplay Between Spin-Vibrational Coupling and Blocking Temperature in Designing High-Performance Pseudo D5h Dy(III) Single Ion Magnets
Authors: Dey Sourav , Sharma Tanu , Rajaraman Gopalan
Published: September 2023

At the cutting edge of high-performance single-molecule magnets (SMMs) lie lanthanide-based complexes, renowned for their potent magnetic anisotropy. The performance of the SMMs is measured generally via the barrier height for magnetization reversal (Ueff) and blocking temperature (TB), below which the magnetization is fully frozen. To enhance the Ueff and TB values in lanthanide-based SMMs, the static crystal field splitting of mJ levels has been effectively adjusted through ligand design, leveraging the oblate/prolate ground state 4f electron density shape. However, the maximum fine-tuning that can be achieved via ligand design called the axial limit is already reached in this class of compounds and demand new design principle to enhance the SMM characteristics to suit end-user applications. Among other avenues that can be explored to improve the SMM characteristics, a deeper understanding of spin-phonon coupling, critical to advancing TB values, offers numerous advantages. However, there are only a handful of examples where this is deciphered. In this work, using a combination of DFT and ab initio CASSCF calculations, we have performed spin-phonon calculations of five classes of pseudo D5h Dy(III) SIMs exhibiting TB value in the range of 4.5 K to 36 K ([Dy(bbpen)Br] (1, H2bbpen=N,N′-bis(2-hydroxybenzyl)-N,N′-bis(2-methylpyridyl)ethylenediamine), [Dy(OCMe3)Br(THF)5][BPh4] (2) [Dy(OSiMe3)Br(THF)5] [BPh4] (3), [Dy(LN5)(Ph3SiO)2](BPh4).CH2Cl2 (4) and [L2Dy(H2O)5][I]3.L2.H2O (5, L = tBuPO(NHiPr)2)). The approach provided here not only reduces the computational cost but also suggests chemical intuition to improve the performance of this class of compounds. Our calculations reveal that low-energy vibrational modes govern the magnetization relaxation in these SIMs. A flexible first coordination sphere found on some of the complexes was found to be responsible for low-energy vibrations that flip the magnetization reducing the TB values drastically (complexes 2 and 3).On the other hand, a rigid first coordination sphere and a stiff ligand framework move the spin-vibrational coupling that causes the relaxation to lie beyond the secondary coordination sphere resulting in the increase of TB values. Learning from this exercise, we have undertaken several in silico models based on these vibrations to improvise the TB values. Some of these predictions were correlated to literature precedents, offering confidence in the methodology employed. To this end, our comprehensive investigation, involving twenty-three molecules/models and five sets of geometries for the pseudo D5h Dy(III) single-ion magnets (SIMs), unveils a treasure trove of chemically sound design clues, poised to enhance the TB values in this fascinating molecular realm.
MS2Mol: A transformer model for illuminating dark chemical space from mass spectra
Authors: Butler Thomas , Frandsen Abraham , Lightheart Rose , Bargh Brian , Kerby Thomas , West Kiana , Davison Joseph , Taylor James , Krettler Christoph , Bollerman TJ , Voronov Gennady , Moon Kevin , Kind Tobias , Dorrestein Pieter , Allen August , Colluru Viswa , Healey David
Published: September 2023

The ability to identify small molecules in complex samples from their mass spectra is among the grand challenges of analytical chemistry. Improvements to this ability could significantly advance fields as diverse as drug discovery, diagnostics, environmental science, and synthetic biology. A primary bottleneck is that standard structure elucidation technologies are limited to identifying only those molecules that are contained in databases of known spectra or molecular structures and are therefore not well suited to identifying the vast majority of potentially billions of natural metabolites, whose structures are not yet catalogued. To improve the identification of molecular structures within this vast dark chemical space, we present MS2Mol, a de novo structure prediction model based on a generative sequence to sequence transformer. We also release EnvedaDark, a first-of-its-kind data set for benchmarking identification performance on unknown metabolites. EnvedaDark contains experimental mass spectra from 226 natural products not currently found in major databases. We demonstrate on this challenging dataset that MS2Mol is able to predict 21% of molecular structures to within a close-match accuracy threshold and 62% to within meaningful similarity, both of which are significant improvements over the closest match retrieved using standard database methods. We further present a confidence scorer that enables practical usage for novel molecule discovery and enriches the accuracy on meaningfully-similar and close-match thresholds to 98% and 63%, respectively, for the top 10% most confident predictions.
The Significance of Life Insurance Sale Management for the Development of the Financial Market
Authors: Nikolić Milena , Milojković Danka , Jemović Mirjana
Published: September 2023

Life insurance companies as institutional investors are key participants in the global financial market. By collecting the savings of the insured, accumulating large amounts of funds and their long-term investment into various financial instruments, these companies affect the development and stability of the financial market. Considering their significance, the aim of this paper is to determine the determinants of life insurance demand by analysing the environment in which these companies operate on the European financial markets, in order to detect the possibilities for increasing the sale of life insurance policies, and thus the amount of collected amount that will be invested in the financial market for a long term. Based on the research results, determinants that may encourage the life insurance demand in European countries are determined and the recommendations on how to manage the sale of life insurance policies, with the aim of increasing the amount of collected funds.
CONDITIONS AND FACTORS AFFECTING POSITIVE INVESTMENT CLIMATE IN THE KYRGYZ REPUBLIC
Authors: Kapakov Bakyt
Published: September 2023

Abstract: In the context of globalization, the investment attractiveness of a country is essential for the economy of the country. The purpose of this paper is to explore the factors affecting the inflow of foreign direct investment in the example of the Kyrgyz Republic as a member of the Eurasian Economic Union (EAEU). The paper introduces the ways and changes in the country’s investment activities and explains how the country attempts to attract investors and improve state legislation, ideology, and economic policy to create a favorable investment climate. The investment climate discussed in this paper as a set of factors plays a decisive role in attracting investment to the country's economy. In addition, this paper identifies the factors determining investment climate that depend on political stability, the transparent legal framework, the tax coefficient, and the attractive benefits, and concludes by emphasizing that all of these factors create a favorable climate for investors and help the Kyrgyz Republic to form a positive investment image.

Keywords: the Kyrgyz Republic, investment attractiveness, investment climate, state investment policy.
Revisión de los Game Studies desde la estética del formalismo y el romanticismo
Authors: Lozano Alejandro
Published: September 2023

El objetivo principal de este artículo es explorar, desde la estética y la teoría de las artes, un corpus de planteamientos teóricos y prácticas que han aparecido entre las décadas de los 2000 y los 2010. En este sentido, lo que propongo es una relectura de las fuentes seleccionadas desde la óptica de dichas estéticas. Ambas corrientes pueden ayudarnos a explorar conexiones entre fuentes que han contribuido de manera determinante a conformar la fisionomía de los Game Studies dentro de las cuestiones de índole más humanística.
Analysis and Research on Interchange and Expansion options of Expressway
Authors: Luo Yaoping
Published: September 2023

China's road network consists of numerous older expressways experiencing high traffic volumes and severe congestion necessitating urgent reconstruction and expansion efforts. This study discusses the reconstruction and expansion project of the Yinkun Expressway's Chongqing High-tech Zone to Rongchang District section with a detailed exploration of the entire design process. Through a comprehensive analysis the strengths and weaknesses of different plans are examined so as to determine the optimal plan. The design chosen saves costs while effectively addressing traffic demands. Additionally the study summarizes the valuable design insights gained from this interchange transformation aiming to provide valuable reference for similar interchange projects in the future.
THE EFFECTIVENESS OF HEALTH EDUCATION THROUGH POP-UP BOOKS AND POCKET BOOKS ON THE LEVELS OF DENTAL AND MOUTH HYGIENE IN SCHOOL-AGE CHILDREN
Authors: Nufus Melia Hayatun , Mariyam Mariyam , Sholekhah Nur Khamilatusy
Published: September 2023

Background: Efforts to maintain healthy teeth and mouth require special attention, especially in school-age children. Data from the Kedungmundu Health Center shows 9,491 students and 3,338 students who need treatment with a percentage of 35.37%. This is minimized by holding counseling or health education through interesting media for children. Media that has a good effectiveness value is the media pop-up book and pocket book.Method: This type of experimental research uses a nonequivalent control group design. The sample in the study were 23 students with pop-up book media and 23 students with pocket books at SD Negeri Kedungmundu, who underwent an OHI-S examination and received counseling interventions with pop-up book media and pocket books with material on maintaining oral hygiene.Result: Counseling using pop-up books and pocket books obtained a significant value of 0.000 (<0.005), which means that there was a difference before and after the intervention was given. The OHI-S score shows that the majority have a good category after being given the pocket book and pop-up book intervention.Conclusion: Counseling with pop-up book media is more effective than pocket book media on the level of dental and oral hygiene in school-age children.
Prevalence And Analysis Factor Risk of Oral Stomatitis In Malays Ethnicity in Indonesia: Panel Data Analysis
Authors: Bakar Abu
Published: September 2023

Indonesia Family Life Survey (IFLS) was used to formulate various policy government . In that survey, respondents were also asked about experience experience thrush (oral stomatitis) during four last week . Objective of this study is to analyze relationship of several risk factors with incident of oral stomatitis of Malays in Indonesia. This cross-sectional study done based on the data obtained from IFLS in 2014. Data analysis used excel software ( univariate data ) and IBM SPSS version 25. Prevalence of oral stomatitis in ethnic Malays in Indonesia are 11% (26 cases of 236 respondents) . Analysis results SPSS shows not significant relationship between age , gender , place residence , education and economic status with incidence of oral stomatitis. There is significant relationship between condition health general with incidence of oral stomatitis (p < 0.05). Study results recommend necessity look after and care cleanliness cavity mouth in patients who have unhealthy condition.