bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk of depression following traumatic limb amputation—a general population-based cohort study
Authors: Lindner Helen , Montgomery Scott , Hiyoshi Ayako
Published: August 2019

Background: Individuals with traumatic limb amputation (TLA) may be at risk of depression, but evidence of increased depression after TLA from longitudinal studies has been limited. It is also unknown whether physical function, cognitive function, and employment prior to amputation affects depression risk. We aimed to examine longitudinal associations between TLA and depression in working age men, and to explore the role of pre-amputation occupational and individual characteristics. Methods: A Swedish national register-based cohort of 189,220 men born between 1952 and 1956, and who attended conscription assessments in adolescence, was followed from 1985 to 2009. Physical, cognitive, and psychological characteristics were measured at the conscription examination, and occupational information was obtained from the 1985 census. Main outcome measures were hospital inpatient and outpatient admissions for depression. Results: In total, 401 men underwent TLA; mean age at amputation was 42.5 years (SD 7.4). Cox regression produced an unadjusted hazard ratio (95% confidence interval) of 2.61 (1.62–4.21) for risk of subsequent depression associated with TLA compared with the general population. Adjustment for occupational, physical, cognitive, and psychological characteristics did not change the association much, producing a hazard ratio of 2.53 (1.57–4.08). Conclusions: TLA is associated with an increased risk of depression in men over more than two decades of follow up. Occupational and individual characteristics prior to amputation did not greatly change depression risk following amputation. We speculate that a coordinated combination of social support and medical management may help reduce persistent depression risk in men who experience amputation.
Predicting the sequential behavior of mobile Internet users based on MSM model
Authors: Li Zhengren , Zhang Xiaohang , Wang Yanyu , Su Xin
Published: August 2019

The behavior of users concerning mobile Internet varies significantly throughout the day. Results from existing studies—which generally simply segment one day into morning, afternoon, and evening—often provide inaccurate predictions of the behavior of users. To improve prediction accuracy, we propose a segment-based multi-state Markov (SBMSM) model for the dynamic time interval segmentation of the sequential behavior of users. The specific procedure of this proposed model can be described as follows: first, we divide each user’s behaviors into minimum unit according to time dimension; then, we merge adjacent time intervals or ensure they are constant according to the similarities in behavior; and finally, a multi-state Markov (MSM) model is trained using the newly constructed data individually. The experimental results illustrate that for 95.78% of users, an SBMSM model performs much better than a naive MSM model and hidden Markov model.
Future of Youth Justice in Japan
Authors: Suzuki Masahiro , Takeuchi Kenji
Published: August 2019

Japanese youth justice has experienced several reforms to date. Currently, a radical revision is under consideration: to lower the age of criminal majority from 20 to 18 years. Japanese scholars and practitioners have since been engaged in debates over this proposal. Drawing on existing empirical research on youth offending and juvenile justice, the purpose of this article is to advance a critical analysis on (in)appropriateness of lowering the age of criminal majority. By focusing on its potential consequences, we also discuss what the future of youth justice in Japan would look like. We conclude with offering research implications.
Teaching spiritual techniques in continuing education programmes to train older adults for community service and volunteer work contributes to self-efficacy and prosocial behaviours: A five-year follow-up study in four South Asian cities
Authors: Pandya Samta P
Published: August 2019

This article presents a five-year follow-up waitlist control design study investigating the impact of a spiritual education programme on self-efficacy and prosocial behaviours of South Asian older adults participating in adult and continuing education initiatives of volunteer work and community service. Intervention group older adults (IN2 = 321) reported higher scores on outcome measures as compared to the waitlist control group (CN2 = 303). Post-intervention outcome scores were higher for participants from Mumbai and Kathmandu, women, middle class, Hindus and Buddhists, single, highly educated, in good health, with an innate desire to volunteer, who attended more than 75% of the spiritual education programme lessons and regularly self-practiced. Self-practice was the strongest predictor of post-test outcomes. Structural equation models indicated that spiritual education programme attendance and self-practice mediated the relationship between socio-demographic moderators and outcomes. The spiritual education programme is a useful intervention and can be incorporated in adult and continuing education training programmes with some refinements for specific subgroups.
Resilience Following Child Maltreatment: Definitional Considerations and Developmental Variations
Authors: Yoon Susan , Howell Kathryn , Dillard Rebecca , Shockley McCarthy Karla , Rae Napier Taylor , Pei Fei
Published: August 2019

Resilience following childhood maltreatment has received substantial empirical attention, with the number of studies on this construct growing exponentially in the past decade. While there is ample interest, inconsistencies remain about how to conceptualize and assess resilience. Further, there is a lack of consensus on how developmental stage influences resilience and how protective factors affect its expression. The current systematic review uses a developmental lens to synthesize findings on resilience following child maltreatment. Specifically, this article consolidates the body of empirical literature in a developmentally oriented review, with the intention of inclusively assessing three key areas—the conceptualization of resilience, assessment of resilience, and factors associated with resilience in maltreatment research. A total of 67 peer-reviewed, quantitative empirical articles that examined child maltreatment and resilience were included in this review. Results indicate that some inconsistencies in the literature may be addressed by utilizing a developmental lens and considering the individual’s life stage when selecting a definition of resilience and associated measurement tool. The findings also support developmental variations in factors associated with resilience, with different individual, relational, and community protective factors emerging based on life stage. Implications for practice, policy, and research are incorporated throughout this review.
Cognitive-Behavioral Therapy for Insomnia: An Effective and Underutilized Treatment for Insomnia
Authors: Rossman Jeffrey
Published: August 2019

Sleep difficulties are an extremely prevalent health problem, with about 33% to 50% of adults reporting regular difficulty falling asleep or staying asleep. About 7% to 18% of adults meet the criteria for an insomnia disorder.1,2 Sleep disruptions contribute to a variety of medical problems, including cognitive impairment, reduced immune function, metabolic imbalance, and exacerbation of psychiatric conditions.3 The most effective nonpharmacological treatment for chronic insomnia is cognitive-behavioral therapy for insomnia (CBT-i). CBT-i produces results that are equivalent to sleep medication, with no side effects, fewer episodes of relapse, and a tendency for sleep to continue to improve long past the end of treatment. The long-term improvements seem to result from the patient learning how to support and promote the body’s natural sleep mechanism. The five key components of CBT-i are sleep consolidation, stimulus control, cognitive restructuring, sleep hygiene, and relaxation techniques. Although CBT-i is a safe and highly effective treatment for insomnia, unfortunately, it is underutilized, primarily because of two reasons: (1) There is currently a shortage of trained CBT-i practitioners. (2) Patient are much more likely to learn about sleep medication as a treatment for their insomnia (via drug advertisements and prescribing physicians) than CBT-i. Physicians and health care providers can play an important role in educating their patients about CBT-i and recommending it as a first-line treatment for chronic insomnia.
Real-Life Neuroscience: An Ecological Approach to Brain and Behavior Research
Authors: Shamay-Tsoory Simone G. , Mendelsohn Avi
Published: August 2019

Owing to advances in neuroimaging technology, the past couple of decades have witnessed a surge of research on brain mechanisms that underlie human cognition. Despite the immense development in cognitive neuroscience, the vast majority of neuroimaging experiments examine isolated agents carrying out artificial tasks in sensory and socially deprived environments. Thus, the understanding of the mechanisms of various domains in cognitive neuroscience, including social cognition and episodic memory, is sorely lacking. Here we focus on social and memory research as representatives of cognitive functions and propose that mainstream, lab-based experimental designs in these fields suffer from two fundamental limitations, pertaining to person-dependent and situation-dependent factors. The person-dependent factor addresses the issue of limiting the active role of the participants in lab-based paradigms that may interfere with their sense of agency and embodiment. The situation-dependent factor addresses the issue of the artificial decontextualized environment in most available paradigms. Building on recent findings showing that real-life as opposed to controlled experimental paradigms involve different mechanisms, we argue that adopting a real-life approach may radically change our understanding of brain and behavior. Therefore, we advocate in favor of a paradigm shift toward a nonreductionist approach, exploiting portable technology in semicontrolled environments, to explore behavior in real life.
Fargo: Seeing the significance of style in television poetics?
Authors: Sexton Max , Lees Dominic
Published: August 2019

This article explores the adaptation of the original film to television and how a strain of art or independent cinema contributed to the development of the first series of Fargo (2014–present). By making this comparison, the transition to television of the storyworld established by the Coen brothers raises questions about who is talking in the TV drama – the Coens or makers of the series. At the same time, Fargo can be more easily explained and understood as a strategy by writers, directors and producers that further complicate ideas to do with Noah Hawley, as its showrunner and the show’s single-author status. In Fargo, fidelity to the Coen brothers as a testament to the memory of the original film is set against questions about the reliability of storytelling using complex imagery. By alternating between different levels of narration signified by its stylistic tonal qualities, Fargo succeeds in producing multiple meanings, representations and effects that call attention to textual pleasures in the complex television series.
The patronising Kantianisms of hospitality ethics in International Relations: Towards a politics of imposition
Authors: Franke Mark FN
Published: August 2019

The contemporary international regime of law and politics regarding human migration largely follows Immanuel Kant’s contradictory approach, supporting the cosmopolitical rights of humans to move and expect hospitality while privileging the rights of sovereign states to assert territorial security against movement. International Relations scholars informed by Jacques Derrida’s ethical theory argue that one may press this tension to positive dynamics through affirmation of the aporia that a secured home is a requirement for the possibility of the hospitality that might undo conflict between migrants and emplaced citizens. Yet, the attraction of Derrida’s critical Kantianism and this revival of hospitality depends on asserting the primacy of habitation to how citizen subjects stand with respect to foreigners who move. It depends on neglecting how any assumption of home is not based on a given home but, rather, on movements to impose the boundaries and bounty of a home. No one faces the movement of others who seek to make home from the position of home but only also in movements of homemaking. Both the citizen and the migrant move in forms of imposition. And it is only in a politics of imposition that rights to move can be affirmed and gain respect.
Influence of blade width and magnetic field strength on the ADC on PROPELLER DWI in head and neck
Authors: Sumikawa Tetsuo , Yabuuchi Hidetake , Sumikawa Chiharu , Nakashima Yoshiteru , Miura Gouji
Published: August 2019

Purpose

The purpose of this study was to investigate the influence of blade width and magnetic field strength on apparent diffusion coefficient values of periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) diffusion-weighted imaging in the head and neck at 1.5 and 3.0 T magnetic resonance imaging.

Methods

Fifteen healthy volunteers (eight men and seven women; mean age 36.4 ± 10.1 years) underwent PROPELLER diffusion-weighted imaging using four blade widths at 3.0 T and three blade widths at 1.5 T. For the multigroup comparison of apparent diffusion coefficient values, we performed analysis of variance and Tukey–Kramer tests. The apparent diffusion coefficient values in each organ were compared among the different blade widths and magnetic field strengths by a t test. Inter and intra-observer agreements regarding apparent diffusion coefficient value measurements were evaluated using the intraclass correlation coefficient.

Results

No significant differences were observed in apparent diffusion coefficient values of the cerebellum in each blade width at both field strengths. The apparent diffusion coefficient values of the right parotid glands were significantly lower for blade width 32 than for blade width 16 at 3.0 T (1.16 × 10–3 mm2/s vs. 1.01 × 10–3 mm2/s; P < 0.05). The apparent diffusion coefficient values of bilateral parotid glands were significantly higher at 1.5 T than at 3.0 T. Intraclass correlation coefficients were almost perfect to substantial in the cerebellum, whereas they showed moderate agreement in the parotid glands.

Conclusion

The largest blade width 32 at 3.0 T and high magnetic field strength lowered the apparent diffusion coefficient values of parotid glands of PROPELLER diffusion-weighted imaging. The apparent diffusion coefficient values in the parotid glands of PROPELLER diffusion-weighted imaging may be affected for blade width and magnetic field strength.
Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors
Authors: Lechner Katharina , von Schacky Clemens , McKenzie Amy L , Worm Nicolai , Nixdorff Uwe , Lechner Benjamin , Kränkel Nicolle , Halle Martin , Krauss Ronald M , Scherr Johannes
Published: August 2019

Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with conventional risk factor control, significant residual risk remains. Recent evidence on non-traditional determinants of cardiometabolic health has advanced our understanding of lifestyle–disease interactions. Chronic exposure to environmental stressors like poor diet quality, sedentarism, ambient air pollution and noise, sleep deprivation and psychosocial stress affect numerous traditional and non-traditional intermediary pathways related to ASCVD. These include body composition, cardiorespiratory fitness, muscle strength and functionality and the intestinal microbiome, which are increasingly recognized as major determinants of cardiovascular health. Evidence points to partially overlapping mechanisms, including effects on inflammatory and nutrient sensing pathways, endocrine signalling, autonomic function and autophagy. Of particular relevance is the potential of low-risk lifestyle factors to impact on plaque vulnerability through altered adipose tissue and skeletal muscle phenotype and secretome. Collectively, low-risk lifestyle factors cause a set of phenotypic adaptations shifting tissue cross-talk from a proinflammatory milieu conducive for high-risk atherosclerosis to an anti-atherogenic milieu. The ketone body ß-hydroxybutyrate, through inhibition of the NLRP-3 inflammasome, is likely to be an intermediary for many of these observed benefits. Adhering to low-risk lifestyle factors adds to the prognostic value of optimal risk factor management, and benefit occurs even when the impact on conventional risk markers is discouragingly minimal or not present. The aims of this review are (a) to discuss novel lifestyle risk factors and their underlying biochemical principles and (b) to provide new perspectives on potentially more feasible recommendations to improve long-term adherence to low-risk lifestyle factors.
How should we theorize algorithms? Five ideal types in analyzing algorithmic normativities
Authors: Lee Francis , Björklund Larsen Lotta
Published: August 2019

The power of algorithms has become a familiar topic in society, media, and the social sciences. It is increasingly common to argue that, for instance, algorithms automate inequality, that they are biased black boxes that reproduce racism, or that they control our money and information. Implicit in many of these discussions is that algorithms are permeated with normativities, and that these normativities shape society. The aim of this editorial is double: First, it contributes to a more nuanced discussion about algorithms by discussing how we, as social scientists, think about algorithms in relation to five theoretical ideal types. For instance, what does it mean to go under the hood of the algorithm and what does it mean to stay above it? Second, it introduces the contributions to this special theme by situating them in relation to these five ideal types. By doing this, the editorial aims to contribute to an increased analytical awareness of how algorithms are theorized in society and culture. The articles in the special theme deal with algorithms in different settings, ranging from farming, schools, and self-tracking to AIDS, nuclear power plants, and surveillance. The contributions thus explore, both theoretically and empirically, different settings where algorithms are intertwined with normativities.
Thoracic vertebral canal stenosis due to articular process hypertrophy in two cats treated by hemilaminectomy with partial osteotomy of the spinous process
Authors: Carletti Beatrice Enrica , Espadas Irene , Sanchez-Masian Daniel
Published: August 2019

Case summary

A 9-year-old neutered female British Shorthair cat (case 1) and a 13-year-old neutered male domestic shorthair cat (case 2) showed signs of chronic T3–L3 myelopathy, which progressed over 6 and 12 months, respectively. On presentation, case 1 had moderate pelvic limb proprioceptive ataxia and ambulatory paraparesis, and case 2 was non-ambulatory paraparetic and had urinary incontinence. Bilateral enlargement of the articular process joints at T11–T12 in case 1 and T3–T4 in case 2 causing dorsolateral extradural spinal cord compression was shown on MRI. Surgical decompression by a unilateral approach through hemilaminectomy with partial osteotomy of the spinous process was performed in both cases. The side of the approach was chosen based on the severity of the cord compression. Surgery resulted in a satisfactory outcome with short hospitalisation times. On discharge, case 1 showed mild postural reaction deficits on both pelvic limbs. Case 2 had regained urinary continence and could ambulate unassisted, although it remained severely ataxic. The 6 month follow-up showed very mild paraparesis and proprioceptive ataxia in both cats. No chronic medical treatment was required.

Relevance and novel information

This is the first report to describe clinical presentation, imaging features, surgical treatment and outcomes of thoracic vertebral canal stenosis owing to bilateral articular process hypertrophy in cats with no adjacent spinal diseases. Thoracic articular process hypertrophy should be included in the differential diagnosis of adult cats with chronic progressive myelopathy. Hemilaminectomy with partial osteotomy of the spinous process might be an appropriate surgical technique in these cases.
Congenital block vertebrae and intervertebral disc protrusion in a young cat
Authors: Crowe Yvette C , Child Georgina , Lam Richard , McGregor Ross
Published: August 2019

Case summary

A 6-month-old domestic shorthair cat was evaluated for proprioceptive ataxia of the pelvic limbs. Over 2 months, the cat became poorly ambulatory, paraparetic with proprioceptive ataxia and developed a firm, distended bladder with intermittent overflow urinary incontinence. Block vertebrae (T1–3, T4–5 and T10–11) and lordosis were identified on radiographs of the vertebral column. MRI revealed T3/4 intervertebral disc protrusion with severe extradural compression, secondary syringohydromyelia caudal to the protrusion and generalised intervertebral disc disease throughout the cervical and thoracic vertebrae. Dorsal laminectomy at T3/4 resulted in resolution of paraparesis and marked improvement in coordination and strength. Block vertebrae are usually considered an incidental finding. In this patient, angular deformation (lordosis) and adjacent segment disease probably contributed to clinically significant intervertebral disc degeneration and protrusion.

Relevance and novel information

There are few case reports in the literature of multiple congenital vertebral malformations causing neurological deficits in cats. This is the first reported case of successful surgical management of intervertebral disc protrusion, possibly secondary to block vertebrae and lordosis in a cat.
Designing wearable technologies for users with disabilities: Accessibility, usability, and connectivity factors
Authors: Moon Nathan W , Baker Paul MA , Goughnour Kenneth
Published: August 2019

The increasing availability of wearable devices (wearables), “smart” home, and other next-generation wirelessly connected devices for work, home, and leisure presents opportunities and challenges for users with disabilities. As augmentative tools for engagement, control, and information, these technologies should not only be usable, but also be accessible and inclusive for people with disabilities. In order to better capture the dimensions of inclusivity of wearable devices, the authors have conducted a review of pertinent literature with respect to a range of representative applications and examples of currently available technologies. Drawing on the findings of the review, the aim of this article is to explore the potential impact of inclusive design principles on future device development for users with disabilities. These observations can help designers incorporate inclusive perspectives into the development process. Such an approach, where people with disabilities constitute an integral part of the development process, will yield products and services that can facilitate increased accessibility, independence, and community participation.
Controlled schools in Northern Ireland – de facto Protestant or de facto secular?
Authors: Gracie Anita , Brown Andrew W
Published: August 2019

The Controlled Schools’ sector in Northern Ireland is usually described as de facto Protestant. By examining its history and current context, this article considers the veracity of that statement. In many schools RE is often ‘squeezed out’ of an already overcrowded timetable. This results in the quantity and quality of RE teaching varying widely, unlike other areas of the curriculum. The article explores whether the sector's ethos is Protestant, secular, Christian or multi-faith. It concludes that, although perhaps unclear about their Protestant identity and uncomfortable about being deemed secular, schools are clear about their de facto Christian status.
Nation-states, transnational corporations and cosmopolitans in the global popular music economy
Authors: Negus Keith
Published: August 2019

This article assesses changing debates about globalisation in light of the growth of digital media. It stresses how popular music is shaped by enduring tensions between nation-state attempts to control territorial borders, the power of transnational corporations aiming to operate across these borders and emergent cosmopolitan practices that offer a cultural challenge to these borders. It outlines how popular music is influenced by physical place and highlights the cultural and political importance of the nation-state for understanding the context within which musical creativity occurs. It explains how transnational corporations use financial power to work across and to gain entry to national boundaries, and assesses claims that cosmopolitanism musical encounters offer more inclusive and alternative spaces to that of bounded state control and unbounded capitalist competition. It concludes by arguing for a more music-centred approach to the powers and pluralisms through which popular music moves at the meeting of states, corporations and cosmopolitans.
Effect of Nursing Care Delivery Models on Registered Nurse Outcomes
Authors: Havaei Farinaz , Dahinten V. Susan , MacPhee Maura
Published: August 2019

The two key components of models of nursing care delivery are mode of nursing care delivery and skill mix. While mode of nursing care delivery refers to the independent or collaborative work of nurses to provide care to a group of patients, skill mix is defined as direct care nurse classifications. Previous research has typically focused on only one component at a time (mode or skill mix). There exists little research that investigates both components simultaneously. This study examined the effect of mode of nursing care delivery and skill mix on nurse emotional exhaustion and job satisfaction after controlling for nurse demographics, workload factors, and work environment factors. A secondary analysis was done with survey data from 416 British Columbia medical–surgical registered nurses. Data were analyzed using hierarchical multiple regression and moderated regression. Registered nurses in a skill mix with licensed practical nurses reported lower emotional exhaustion when caring for more acute patients compared with those in a skill mix without licensed practical nurses. While mode of nursing care delivery was not related to nurse outcomes, work environment factors were the strongest predictors of both nurse outcomes. Skill mix moderated the relationship between patient acuity and emotional exhaustion. Nurse managers should invest in nurses’ conditions of work environments.
Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis
Authors: Ling Te , Birger Yehudit , Stankiewicz Monika J. , Ben-Haim Nissim , Kalisky Tomer , Rein Avigail , Kugler Eitan , Chen Wei , Fu Chunling , Zhang Kevin , Patel Hiral , Sikora Jacek W. , Goo Young Ah , Kelleher Neil , Zou Lihua , Izraeli Shai , Crispino John D.
Published: August 2019

GATA1 has a foundational role in erythropoiesis. The investigators compare the function of 2 forms (the full-length protein and a shorter form) of the transcription factor GATA1 and show that the N-terminal domain of GATA1 is critical to red cell differentiation.
Electrical impedance tomography during spontaneous breathing trials and after extubation in critically ill patients at high risk for extubation failure: a multicenter observational study
Authors: Longhini Federico , Maugeri Jessica , Andreoni Cristina , Ronco Chiara , Bruni Andrea , Garofalo Eugenio , Pelaia Corrado , Cavicchi Camilla , Pintaudi Sergio , Navalesi Paolo
Published: August 2019

Background

This study aims to assess the changes in lung aeration and ventilation during the first spontaneous breathing trial (SBT) and after extubation in a population of patients at risk of extubation failure.

Methods

We included 78 invasively ventilated patients eligible for their first SBT, conducted with low positive end-expiratory pressure (2 cm H2O) for 30 min. We acquired three 5-min electrical impedance tomography (EIT) records at baseline, soon after the beginning (SBT_0) and at the end (SBT_30) of SBT. In the case of SBT failure, ventilation was reinstituted; otherwise, the patient was extubated and two additional records were acquired soon after extubation (SB_0) and 30 min later (SB_30) during spontaneous breathing. Extubation failure was defined by the onset of post-extubation respiratory failure within 48 h after extubation. We computed the changes from baseline of end-expiratory lung impedance (∆EELI), tidal volume (∆Vt%), and the inhomogeneity index. Arterial blood was sampled for gas analysis. Data were compared between sub-groups stratified for SBT and extubation success/failure.

Results

Compared to SBT success (n = 61), SBT failure (n = 17) showed a greater reduction in ∆EELI at SBT_0 (p < 0.001) and SBT_30 (p = 0.001) and a higher inhomogeneity index at baseline (p = 0.002), SBT_0 (p = 0.003) and SBT_30 (p = 0.005). RR/Vt was not different between groups at baseline but was significantly greater at SBT_0 and SBT_30 in SBT failures, compared to SBT successes (p < 0.001 for both). No differences in ∆Vt% and arterial blood gases were observed between SBT success and failure. The ∆Vt%, ∆EELI, inhomogeneity index and arterial blood gases were not different between patients with extubation success (n = 39) and failure (n = 22) (p > 0.05 for all comparisons).

Conclusions

Compared to SBT success, SBT failure was characterized by more lung de-recruitment and inhomogeneity. Whether EIT may be useful to monitor SBT remains to be determined. No significant changes in lung ventilation, aeration or homogeneity related to extubation outcome occurred up to 30 min after extubation.

Trial registration Retrospectively registered on clinicaltrials.gov (Identifier: NCT03894332; release date 27th March 2019).
Parametric convolutional neural network-domain full-waveform inversion
Authors: Wu Yulang , McMechan George A.
Published: August 2019

Most current full-waveform inversion (FWI) algorithms minimize the data residuals to estimate a velocity model based on the assumption that the updated model is the sum of a background model and an estimated model perturbation. We have performed reparameterization of the initial velocity model, by the weights in a convolutional neural network (CNN), to automatically capture the salient features in the initial model, as a priori information. The prior information in CNN weights is iteratively updated as regularization to constrain the CNN-domain inversion to refine the features captured in CNN pretraining by reducing the data misfit. Synthetic examples using a 1D increasing velocity function v(z) and a 2D smoothed version of the correct Marmousi2 model as initial models indicate that the performance of the CNN-domain FWI depends on the existence and accuracy of the prior information in the initial velocity model (i.e., whether features whose positions, shapes, and values are present in the correct model are approximately included in the initial model). Forty different sets of randomly initialized CNN weights are used to parameterize and test CNN-domain FWI, using a 2D smoothed Sigsbee model as the initial velocity model. All 40 sets invert for the Sigsbee salt body more accurately (with a smaller standard deviation of the final rms model errors), by CNN-domain FWI, than FWI does. Features that are not represented within the CNN hidden layers in the initial velocity model, and so cannot be recovered by CNN-domain FWI, can be recovered using the final CNN-domain FWI velocity model as the starting model in a subsequent conventional FWI.
Section 12 approval: fit for purpose?
Authors: Rigby David , McAlpine Lynsey
Published: August 2019

In light of the increasing numbers of detentions of mentally unwell patients in the UK and the recent review of the Mental Health Act, this editorial seeks to analyse the process of Section 12 approval of doctors from a medical educational perspective. We compare the approval mechanisms with assessments in other specialities and suggest evidence-based improvements. We believe that a rethinking of the Royal College of Psychiatrists' learning objectives for Section 12 approval and the introduction of a summative assessment would improve the knowledge and skills of clinicians performing an important and scrutinised role within our society.
Lipid Profiling of Peri-implantation Endometrium in Patients With Premature Progesterone Rise in the Late Follicular Phase
Authors: Li Jingjie , Gao Yue , Guan Lihuan , Zhang Huizhen , Chen Pan , Gong Xiao , Li Dongshun , Liang Xiaoyan , Huang Min , Bi Huichang
Published: August 2019

Context

Late follicular phase elevation in serum progesterone (P) during controlled ovarian hyperstimulation negatively affects the outcome of assisted reproductive technology by contributing to endometrial-embryo asynchrony. There are still no data on lipid metabolite alterations during this process.

Objectives

To investigate alterations in the lipid profile during the window of implantation in patients with premature P rise.

Design

Lipidomic variations in the endometrium were evaluated by ultrahigh-performance liquid chromatography coupled with electrospray ionization high-resolution mass spectrometry.

Setting

University assisted reproductive medicine unit.

Patients or Other Participants

Forty-three patients undergoing in vitro fertilization/intracytoplasmic sperm injection because of a tubal factor or male factor infertility were included in this study. The patients were divided into a high P group (P ≥ 1.5 ng/mL, 15 patients) and a normal P group (P < 1.5 ng/mL, 28 patients) on the day of human chorionic gonadotropin administration.

Interventions

The endometrial tissues were obtained by Pipelle biopsy 7 days after human chorionic gonadotropin administration.

Main Outcome Measures

Alterations in lipid metabolites.

Results

A total of 1026 ions were identified, and 25 lipids were significantly upregulated. The endometrial lipid profile was characterized by substantial increases in the concentrations of phosphatidylcholine, phosphatidylethanolamine, lysophosphatidylcholine, diacylglycerol, ceramide, phosphatidylinositol, and phosphatidylserine in patients with a premature P rise at the end of the follicular phase. The correlation analysis between P levels and lipids showed a stronger negative correlation between phosphatidylethanolamine or phosphatidylserine and P levels.

Conclusions

Premature P elevation disrupts the lipid homeostasis of the endometrium during the peri-implantation period. The altered lipid levels may impair endometrial receptivity and early embryo implantation.
Hepatic Fatty Acid Balance and Hepatic Fat Content in Humans With Severe Obesity
Authors: Lytle Kelli A , Bush Nikki C , Triay Jessica M , Kellogg Todd A , Kendrick Michael L , Swain James M , Gathaiya Nicola W , Hames Kazanna C , Jensen Michael D
Published: August 2019

Objective

Nonalcoholic fatty liver disease can lead to hepatic inflammation/damage. Understanding the physiological mechanisms that contribute to excess hepatic lipid accumulation may help identify effective treatments.

Design

We recruited 25 nondiabetic patients with severe obesity scheduled for bariatric surgery. To evaluate liver export of triglyceride fatty acids, we measured very-low-density lipoprotein (VLDL)–triglyceride secretion rates the day prior to surgery using an infusion of autologous [1-14C]triolein-labeled VLDL particles. Ketone body response to fasting and intrahepatic long-chain acylcarnitine concentrations were used as indices of hepatic fatty acid oxidation. We measured intraoperative hepatic uptake rates of plasma free fatty acids using a continuous infusion of [U-13C]palmitate, combined with a bolus dose of [9,10-3H]palmitate and carefully timed liver biopsies. Total intrahepatic lipids were measured in liver biopsy samples to determine fatty liver status. The hepatic concentrations and enrichment from [U-13C]palmitate in diacylglycerols, sphingolipids, and acyl-carnitines were measured using liquid chromatography/tandem mass spectrometry.

Results

Among study participants with fatty liver disease, intrahepatic lipid was negatively correlated with VLDL-triglyceride secretion rates (r = −0.92, P = 0.01) but unrelated to hepatic free fatty acid uptake or indices of hepatic fatty acid oxidation. VLDL-triglyceride secretion rates were positively correlated with hepatic concentrations of saturated diacylglycerol (r = 0.46, P = 0.02) and sphingosine-1-phosphate (r = 0.44, P = 0.03).

Conclusion

We conclude that in nondiabetic humans with severe obesity, excess intrahepatic lipid is associated with limited export of triglyceride in VLDL particles rather than increased uptake of systemic free fatty acids.
Polarization, Participation, and Premiums: How Political Behavior Helps Explain Where the ACA Works, and Where It Doesn't
Authors: Trachtman Samuel
Published: August 2019

Context: Political partisanship can influence whether individuals enroll in government programs. In particular, Republicans, ceteris paribus, are less likely to enroll in Affordable Care Act (ACA) individual marketplace insurance than Democrats. The logic of adverse selection suggests low uptake among Republicans would generally put upward pressure on marketplace premiums, especially in geographic areas with more Republican partisans.

Methods: Using data from Healthcare.gov at the rating area level, this article examines the association between Republican vote share and growth in ACA marketplace premiums, being careful to account for potential confounding variables.

Findings: Insurers have increased marketplace premiums at higher rates in areas with more Republican voters. In the preferred model specification, a 10-percentage-point difference in Republican vote share is associated with a 3.2-percentage-point increase in average premium growth for a standard plan. A variety of robustness and placebo checks suggest the relationship is driven by partisanship.

Conclusions: Partisan polarization can threaten the successful implementation of policies that rely on high levels of citizen participation.
Affordable Care Act Moving to New Stage of Public Acceptance
Authors: Jacobs Lawrence R. , Mettler Suzanne , Zhu Ling
Published: August 2019

The Affordable Care Act (ACA) was enacted in a deeply polarized context, and it has endured multiple challenges to its implementation and its very existence that continue to this day. Yet, we find that the law is entering a new phase of acceptance among the American public, such that it presents political risks to politicians who would dare to weaken it. We have conducted a panel study of Americans' public opinion on the ACA since 2010, returning to the same respondents every two years to ask the same questions. This approach, which is essential for tracking change, reveals that support for the ACA is growing and the most intense opposition is receding. It also shows that Americans' sense of the law's impact on their lives is at least holding steady and in some respects growing. Most strikingly, those who feel favorably toward the law are more engaged politically than those who oppose it, and they are more likely to take it into account when they vote. These trends indicate that the law, despite the legal and political obstacles it still confronts, is becoming more firmly established in public opinion and through patterns of political participation.
Performing Piety in Pakistan's Transgender Rights Movement
Authors: Pamment Claire
Published: August 2019

Pakistani hijra/khwaja siras make up structured communities of feminine-identified gender-variant persons who have long but marginalized traditions of performing religious-cultural roles. Supreme Court rulings in 2009, promising rights to marginalized khwaja siras, have led to increased backlash against these performances and the community structures on which they rest. This article explores these traditional performance practices, within the Sufi shrine and in homes, as well as in explicit activism as khwaja siras contested their place in the national 2013 elections. These assertions of piety, drawn creatively from Sufi and Shi'a modes and often performed on the fringes or lower rungs of developmental activism, offer an embodied outlet for negotiating multiple axes of exclusion. While recent scholarship has claimed that in the context of reformist Islamic movements khwaja siras are turning away from the spaces of legitimacy that Sufism once offered and toward the liberal language of human rights to make claims for recognition, the author argues that these pious performances continue to provide a potent force for transgender activism in Pakistan.
The MuslimWariaof Yogyakarta
Authors: Rodriguez Diego Garcia
Published: August 2019

Based on fieldwork conducted with Muslim waria (a term roughly translated as transgender women) in the city of Yogyakarta, Indonesia, this article analyzes the gendered, sexual, and religious lived realities of these individuals. Drawing on research comprising ten in-depth, semistructured interviews, and observations at the pesantren waria (Islamic boarding school for Muslim waria), this article investigates the ways in which the participants construct their “wariahood” in relation to the assumed presence of a jiwa perempuan (female soul/spirit), challenging the common conflation of agency with resistance. The empirical discussion first explores the emergence of the waria subject position through the existence of their female jiwa, while the second part addresses the importance of Islam as a source of potential agentic power for these individuals.
The expanding spectrum of neurological disorders of phosphoinositide metabolism
Authors: Volpatti Jonathan R. , Al-Maawali Almundher , Smith Lindsay , Al-Hashim Aqeela , Brill Julie A. , Dowling James J.
Published: August 2019

Phosphoinositides (PIPs) are a ubiquitous group of seven low-abundance phospholipids that play a crucial role in defining localized membrane properties and that regulate myriad cellular processes, including cytoskeletal remodeling, cell signaling cascades, ion channel activity and membrane traffic. PIP homeostasis is tightly regulated by numerous inositol kinases and phosphatases, which phosphorylate and dephosphorylate distinct PIP species. The importance of these phospholipids, and of the enzymes that regulate them, is increasingly being recognized, with the identification of human neurological disorders that are caused by mutations in PIP-modulating enzymes. Genetic disorders of PIP metabolism include forms of epilepsy, neurodegenerative disease, brain malformation syndromes, peripheral neuropathy and congenital myopathy. In this Review, we provide an overview of PIP function and regulation, delineate the disorders associated with mutations in genes that modulate or utilize PIPs, and discuss what is understood about gene function and disease pathogenesis as established through animal models of these diseases.
Between Political Nation and Ethnic‑Cultural Nation: Nations in Central Europe in the 20th Century
Authors: Paruch Waldemar
Published: August 2019

The article analyzes the nation‑building process in Central Europe in the context of conditions and specific character of historical processes. It identifies the origin of the dilemma in Central Europe: political or ethnic‑cultural nations. The study shows why ethnic‑cultural communities developed in this region. It also describes the extent and the dynamics of disputes over the problem between the most important political trends arisen in Central Europe, and emphasizes the intensity of rivalry over this question in the interwar years, primarily in the Second Republic of Poland, the Kingdom of Hungary, and Czechoslovakia. The paper also analyzes the style of thinking practiced by the adherents to the concept of Central European political nations: Józef Piłsudski, Tomaš G. Masaryk, and Miklós Horthy.
The “Velvet Split ” of Czechoslovakia (1989‑1992)
Authors: Rychlík Jan
Published: August 2019

The elections in June 1992 brought to power Vladimir Meciar‘s Movement for Democratic Slovakia (HZDS) in Bratislava and Vaclav Klaus‘ Civic Democratic Party (ODS) in Prague. In the concept of HZDS the idea of a parity (which is impossible to achieve between two units of differing size) gradually came to be associated with the concept of “Slovak sovereignty” and Slovakia’s “international legal subjectivity”, both incompatible with Czechoslovakia’s further existence. Such confederative model brought Czechs nothing but troubles. Subsequently, Prague now lost interest in keeping Slovakia within the Czechoslovak state. The result was “the velvet divorce” of Czechoslovakia on 31 December 1992.
Trick film: Neil Brand’s radio dramas and the silent film experience
Authors: McMurtry Leslie
Published: August 2019

At first glance, silent film and audio drama may appear antithetical modes of expression. Nevertheless, an interesting tradition of silent film-to-radio adaptations has emerged on BBC Radio Drama. Beyond this link between silent film and radio drama, Neil Brand, a successful silent film accompanist, radio dramatist and composer, links the silent film experience and audio drama in two of his plays, Joanna and Waves Breaking on a Shore. Using theories of sound and narrative in film and radio, as well as discussing the way radio in particular can stimulate the generation of imagery, this article examines layered points of view/audition as ways of linking the silent film experience and the use of sound within radio drama.
From re-viewers to me-viewers: The #Bookstagram review sphere on Instagram and the uses of the perceived platform and genre affordances
Authors: Jaakkola Maarit
Published: August 2019

This study looks at the emerging forms of reviewing cultural products by investigating #bookreviews on Instagram. The multiple-case study focuses on characteristics of book-review posts in global and national contexts. First, the global community is outlined, with the help of quantitative data (N = 163,269 entries). Second, a local book-reviewing community (N = 645 entries) is studied, with a thematic analysis of platform and genre affordances. Instagram-native formats identified include textual reviews, metacoverage of reviews, video reviews, reviews with visual effects and facilitated reviews. The findings have implications for the conceptualization of user-generated reviewing as part of cultural critique, which requires the incorporation of the consumption/prosumption paradigm into the understandings of cultural intermediation.
Breaking Bad and disabilities: Neo-liberalism, crip studies and critiques of ableism in the classroom
Authors: Cordeiro Will
Published: August 2019

AMC’s hit television series Breaking Bad has a devoted fan base, and critics have explored the show’s relationship to television’s ‘Third Golden Age’ through binge-watching, philosophy and sociopolitical crises. Many critics, however, neglect to explore the show’s discussion of issues related to disability. Breaking Bad depicts diverse experiences of people with disabilities. The show uses disability as a way to demonstrate how differing philosophical viewpoints about brains and bodies create different identities and different narratives about those identities. This way of uncovering the narratives of the show can be used pedagogically to provide alternatives to a medical model of disability, and explore in the classroom how disability intersects with class, race, gender and other identities.