bluuebunny/crossref_metadata_2025 huggingface dataset:
Modern technologies of venous ulcers treatment in elderly population
Authors: Turkin P. Yu. , Slesareva A. A. , Rodionov S. V. , Varich G. A. , Kuzhuget A. A. , Ponomar S. A.
Published: May 2022

Venous trophic ulcers take place in the terminal stage of chronic venous insufficiency. The problem of venous trophic disorders is extremely relevant due to the high prevalence among the population. This review considers the comparative characteristics of morbidity data on the example of Germany and the Russian Federation. Particular attention paid to the influence of the course of the disease on patient’s life quality during treatment. The causes of high-cost treatment are reported with approximate calculations for 1 clinical case and total annual costs according to foreign researchers (Australia, Great Britain, USA). The risk factors are discussed in the form of certain concomitant nosologies that significantly aggravate the healing process of ulcers with a brief description of the pathogenesis. The review defines the main goals of the treatment of venous trophic ulcers, as well as separate groups of directions in which it is reasonable to carry out therapeutic measures. Article presents a comparative analysis between the methods of applying compression therapy (elastic bandaging, the use of special stockings) and the influence of the choice on the quality of life of patients. Various methods of topical wound care are described with the obligatory consideration of the stage of the wound process, alternative methods of local treatment are listed (for example, the use of autologous platelet-rich plasma). The efficacy of systemic pharmacotherapy in trophic disorders and the treatment potential of various groups of drugs on the rate of ulcer healing were evaluated. The advantages of using surgical treatment are determined, the main surgical techniques are listed, highlighting the advantages and disadvantages of each. Possible treatment strategies for elderly patients also discussed. The complexity of evaluating the effectiveness of new techniques and an integrated approach to treatment is shown, which in the future will help to correct the direction of finding new ways to solve the problem of venous ulcers in this specific group of patients.
Influence of treatment methods on quality of life of patients with hemorrhoidal disease
Authors: Zagriadskiǐ E. A. , Bogomazov A. M. , Golovko E. B. , Abritsova M. V.
Published: May 2022

Introduction. The effectiveness of the treatment of hemorrhoidal disease is based on the frequency of recurrence of hemorrhoid symptoms, the development of early and late postoperative complications, as well as the degree of patient satisfaction with the results of treatment. However, such an indicator as quality of life, which reflects the health of the patient, is not taken into account.

Aim. Obtaining data on the influence of the method and type of treatment on the quality of life of patients suffering from acute or chronic hemorrhoids.

Materials and methods. The analysis of the influence of the treatment method on the quality of life of patients suffering from acute or chronic hemorrhoids was carried out. The analysis included 1032 patients with stage I–IV hemorrhoids. The age of the patients was 44.8 ± 13.0 (18–94) years. The study included 509 (49.3%) men and 523 (50.7%) women.

Results. Quality of life indicators before treatment in all groups are within the reference values, which is associated with adaptation of patients to the disease. After treatment, quality of life indicators naturally increase. However, in patients after hemorrhoidectomy, regardless of the nature of the technique, quality of life indicators are significantly lower than in patients of groups 1 and 2.

Conclusions. Quality of life indicators in all groups before treatment are within the reference values and do not have statistically significant differences in the considered indicators. After the treatment, there is a statistically significant increase in the quality of life indicators in all scales. After hemorrhoidectomy, regardless of the nature of the technique, quality of life indicators are significantly lower than in patients of groups 1 and 2, which is associated with surgical trauma. Since the groups of patients are heterogeneous in terms of the stages of the disease, it can be assumed that for each stage of hemorrhoids, there is a subjective perception of the disease, which can be reflected in the quality of life indicators, which requires additional analysis of the results obtained.
Experience of homeopathic ointment during the non-surgical treatment for acute hemorrhoids in the outpatient settings
Authors: Belik B. M. , Kovalev A. N.
Published: May 2022

Introduction. The use of traditional anti-inflammatory and local anesthetic preparations during the non-surgical treatment of acute hemorrhoids is liable to cause the progression of serious side effects in patients.

Purpose of the study. To evaluate the clinical efficacy of homeopathic ointment as the topical preparation in the complex treatment of patients with acute hemorrhoids on the outpatient settings.

Materials and methods. The comparative analysis of the results of the non-surgical treatment was conducted and applied to 48 patients with acute hemorrhoids of 1–3 degrees, who were divided into two groups. In 23 patients (control group), traditional non-surgical treatment was conducted without the use of topical preparations. In 25 patients (the main group), traditional preparation therapy was supplemented with local treatment using homeopathic ointment.

Results. In the patients of the main group, a faster regression of pain syndrome and other manifestations of the disease (itching, burning and discomfort in the anal canal, perianal edema) was noted in the dynamics of treatment, and higher values of quality of life parameters were recorded than in patients of the control group. In the main group, good and satisfactory treatment results were obtained in 23 (92.0%) patients, unsatisfactory – in 2 (8.0%) patients. In the control group, good and satisfactory treatment results were observed in 18 (78.3%) patients, unsatisfactory results – in 5 (21.7%) patients.

Discussion. The maximum therapeutic effect with topical application of ointment was observed in patients with acute hemorrhoids of 2–3 degrees, the disease in which proceeded with a pronounced inflammatory-allergic component.

Conclusion. Our results allow us to consider homeopathic ointment as an alternative topical preparation in the non-surgical treatment of acute hemorrhoids in outpatient settings in patients with serious contraindications to the use of traditional topical preparations.
Propiedades psicométricas de la versión en español de la Escala de Atención Plena (Mindfulness) Interpersonal en la Parentalidad en madres de preescolares en Chile
Authors: Corthorn Carolina , Duncan Larissa , Manzi Jorge , Pedrero Victor
Published: May 2022

Las propiedades psicométricas de la versión en español de la escala de Atención Plena (Mindfulness) Interpersonal en la Parentalidad (IM-P) fueron examinadas en una muestra de 111 madres de niños y niñas de edad preescolar en Santiago de Chile. La estructura de cinco factores de la escala IM-P original no fue completamente respaldada mediante análisis factorial confirmatorio. Por lo tanto, se testeó una estructura de cuatro factores. Dos de los factores encontrados fueron coherentes con aquellos originalmente hipotetizados. Los otros consistieron en una re-agrupación de items de las subescalas Consciencia Emocional de si misma y del hijo(a), Aceptación sin juicio de si misma y del hijo(a) y Compasión hacia si misma y hacia su hijo(a), en dos factores: uno que da cuenta de compasión y no-juicio de la madre hacia si misma y, el otro que da cuenta de la compasión, no-juicio y consciencia emocional de la madre hacia su hijio. La versión resultante de cuatro factores y sus sub-escalas presentaron buena consistencia interna. Se analizó la validez de constructo mediante cálculo de correlaciones con mindfulness general (Cuestionario de cinco dimensiones de Mindfulness, FFMQ). Como se esperaba, se encontró una correlación positiva significativa entre las dos medidas (r=0.71, p<0.01), y entre la mayor parte de las subescalas. En general, los resultados dan cuenta de buenas propiedades psicométricas de la versión en español de la escala IM-P en madres de niños y niñas preescolares en Chile.
Evidencias de validez del Inventario NEO-FFI en adultos mayores colombianos
Authors: Reyes-Rodriguez Maria Fernanda , Maldonado Natalia , Trujillo Adriana , Chaparro Eva , Satorres Encarnación , Meléndez Juan Carlos
Published: May 2022

El uso de instrumentos para evaluar la personalidad es una práctica común en psicología, de ahí que su validación y adaptación a diferentes grupos poblacionales sea fundamental. El objetivo de la presente investigación fue evaluar la validez de constructo del NEO Five Factor Inventory (NEO-FFI) en un grupo de 617 personas adultas mayores en Bogotá, Colombia. Se realizaron análisis factoriales confirmatorios, así como un análisis bifactorial. Los resultados mostraron que el inventario no logra un ajuste adecuado en ninguno de los modelos de primer orden, ni en el modelo bifactorial, como tampoco en el análisis de los factores por separado. Solamente, presentó un ajuste adecuado en los modelos AFC modificados que evalúan cada factor como individual, a excepción del factor Amabilidad. Precisamente, los ítems que tuvieron bajas cargas factoriales son aquellos ítems negativos o reversos, y, dado que la comprensión de este tipo de ítems requiere de mejores habilidades lingüísticas, se infiere que el bajo nivel educativo de las personas que conformaron la muestra pudo interferir en el logro de un ajuste adecuado de los modelos; en consecuencia, se recomienda estudiar este aspecto en futuras investigaciones.
Use of Multiple Correspondence Analysis and K-means to Explore Associations Between Risk Factors and Likelihood of Colorectal Cancer: Cross-sectional Study
Authors: Florensa Dídac , Mateo-Fornés Jordi , Solsona Francesc , Pedrol Aige Teresa , Mesas Julió Miquel , Piñol Ramon , Godoy Pere
Published: May 2022

Background

Previous works have shown that risk factors are associated with an increased likelihood of colorectal cancer.

Objective

The purpose of this study was to detect these associations in the region of Lleida (Catalonia) by using multiple correspondence analysis (MCA) and k-means.

Methods

This cross-sectional study was made up of 1083 colorectal cancer episodes between 2012 and 2015, extracted from the population-based cancer registry for the province of Lleida (Spain), the Primary Care Centers database, and the Catalan Health Service Register. The data set included risk factors such as smoking and BMI as well as sociodemographic information and tumor details. The relations between the risk factors and patient characteristics were identified using MCA and k-means.

Results

The combination of these techniques helps to detect clusters of patients with similar risk factors. Risk of death is associated with being elderly and obesity or being overweight. Stage III cancer is associated with people aged ≥65 years and rural/semiurban populations, while younger people were associated with stage 0.

Conclusions

MCA and k-means were significantly useful for detecting associations between risk factors and patient characteristics. These techniques have proven to be effective tools for analyzing the incidence of some factors in colorectal cancer. The outcomes obtained help corroborate suspected trends and stimulate the use of these techniques for finding the association of risk factors with the incidence of other cancers.
Establishing Institutional Scores With the Rigor and Transparency Index: Large-scale Analysis of Scientific Reporting Quality
Authors: Menke Joe , Eckmann Peter , Ozyurt Ibrahim Burak , Roelandse Martijn , Anderson Nathan , Grethe Jeffrey , Gamst Anthony , Bandrowski Anita
Published: May 2022

Background

Improving rigor and transparency measures should lead to improvements in reproducibility across the scientific literature; however, the assessment of measures of transparency tends to be very difficult if performed manually.

Objective

This study addresses the enhancement of the Rigor and Transparency Index (RTI, version 2.0), which attempts to automatically assess the rigor and transparency of journals, institutions, and countries using manuscripts scored on criteria found in reproducibility guidelines (eg, Materials Design, Analysis, and Reporting checklist criteria).

Methods

The RTI tracks 27 entity types using natural language processing techniques such as Bidirectional Long Short-term Memory Conditional Random Field–based models and regular expressions; this allowed us to assess over 2 million papers accessed through PubMed Central.

Results

Between 1997 and 2020 (where data were readily available in our data set), rigor and transparency measures showed general improvement (RTI 2.29 to 4.13), suggesting that authors are taking the need for improved reporting seriously. The top-scoring journals in 2020 were the Journal of Neurochemistry (6.23), British Journal of Pharmacology (6.07), and Nature Neuroscience (5.93). We extracted the institution and country of origin from the author affiliations to expand our analysis beyond journals. Among institutions publishing >1000 papers in 2020 (in the PubMed Central open access set), Capital Medical University (4.75), Yonsei University (4.58), and University of Copenhagen (4.53) were the top performers in terms of RTI. In country-level performance, we found that Ethiopia and Norway consistently topped the RTI charts of countries with 100 or more papers per year. In addition, we tested our assumption that the RTI may serve as a reliable proxy for scientific replicability (ie, a high RTI represents papers containing sufficient information for replication efforts). Using work by the Reproducibility Project: Cancer Biology, we determined that replication papers (RTI 7.61, SD 0.78) scored significantly higher (P<.001) than the original papers (RTI 3.39, SD 1.12), which according to the project required additional information from authors to begin replication efforts.

Conclusions

These results align with our view that RTI may serve as a reliable proxy for scientific replicability. Unfortunately, RTI measures for journals, institutions, and countries fall short of the replicated paper average. If we consider the RTI of these replication studies as a target for future manuscripts, more work will be needed to ensure that the average manuscript contains sufficient information for replication attempts.
Decision Support Tools in Adult Long-Term Care Facilities: A Scoping Review (Preprint)
Authors: Lapp Linda , Egan Kieren , McCann Lisa , Mackenzie Moira , Wales Ann , Maguire Roma
Published: May 2022

BACKGROUND

Despite the considerable potential of digital health approaches to help with continued staff shortages and improve quality of care, digital innovations are yet to make real impacts in the care home sector. To understand the current landscape of digital innovation in long-term care facilities, such as nursing and care homes, it is important to find out which clinical decision support tools are currently used in long-term care facilities, what their purpose is, how these were developed, and what types of data these tools use.

OBJECTIVE

The aim of this review was to analyze studies which evaluated clinical decision support tools in long term care facilities to contribute to the existing scientific evidence to inform a roadmap for digital innovation, specifically for clinical decision support tools, in long-term care facilities.

METHODS

A review of the published literature between 1st of January 2010 to 21st of July 2021 was conducted, using key search terms in three scientific journal databases: PubMed, Cochrane Library and the British Nursing Index. Only studies evaluating clinical decision support tools in long-term care facilities were included in the review.

RESULTS

In total, 17 papers were included in the final review. The found clinical decision support tools were evaluated for medication management, pressure ulcers, dementia management, falls, hospitalization, malnutrition, urinary tract infection, and COVID-19. In general, the found studies show that decision support can show improvements in delivery of care and in health outcomes.

CONCLUSIONS

Even though the studies demonstrate the potential of positive impact of clinical decision support tools, there is variability in results – due in part to the diversity of types of decision support tools, users, and contexts; limited validation of the tools in use; and in part to the lack of clarity in defining the whole intervention.
A Systematic Review and Meta-Analysis of Digital Interventions for Psychological Well-Being in University Students. (Preprint)
Authors: Ferrari Madeleine , Allan Stephanie , Arnold Chelsea , Eleftheriadis Dina , Alvarez-Jimenez Mario , Gumley Andrew , Gleeson John
Published: May 2022

BACKGROUND

Life at university provides important opportunities for personal growth, however, this developmental phase also coincides with the peak period of risk for onset of mental health disorders. In addition, specific university lifestyle factors, including impaired sleep and academic and financial stress, are known to exacerbate psychological distress in students. As a result, university students have been identified as a vulnerable population who often experience significant barriers to accessing psychological treatment. Digital psychological interventions are emerging as a promising solution for this population, but their effectiveness remains unclear.

OBJECTIVE

This systematic review and meta-analysis assessed digital interventions targeting Psychological Well-Being (PWB) for university students.

METHODS

Database searches were conducted 02.12.2021 via EMBASE, MEDLINE, PsycINFO, and Web of Science.

RESULTS

Thirteen eligible studies were identified; 10 included in a meta-analysis. Mean pre-post effect sizes indicated such interventions led to small and significant PWB improvement (g=0.32, 95% CIs 0.23 to 0.40, P<.001). These effects remained, albeit smaller, when studies which included a waitlist control group were excluded (g=0.22, 95% CIs 0.08 to 0.35, P=0.002). An analysis of Acceptance and Commitment Therapy approaches revealed small and significant effects (k=6, g=0.35, 95% CIs 0.25 to 0.45, P<.001).

CONCLUSIONS

Online interventions hold considerable promise for university students, although features that optimise service delivery and outcome require further assessment.

CLINICALTRIAL

PROSPERO Trial Registration: CRD42020196654
Acceptability of Telemedicine by Parents of Adolescent Patients in an Adolescent Clinic (Preprint)
Authors: Coker Adetola , Cervantes Marbella , Dowshen Nadia , Kuhns Lisa , Dhar Cherie Priya
Published: May 2022

UNSTRUCTURED

This study describes the level of accessibility and satisfaction expressed by caregivers of adolescent patients regarding telemedicine visits in an urban Adolescent Medicine practice. Cross-sectional surveys were sent electronically to parents/guardians of patients <18 years of age who completed outpatient telemedicine visits to an Adolescent Medicine practice in Chicago, Illinois from March 2020-February 2021 with questions focused on accessibility and satisfaction. Data were analyzed using response frequencies. Among a sample of 71 survey respondents, the vast majority reported that telemedicine was easy to use and was at least as convenient as in-person visits. Also, over 90% reported that the adolescents’ needs were addressed and that they were at least as comfortable with the level of privacy and confidential conversations with their adolescent in comparison to in-person visits. These finding suggest that parents/guardian find telemedicine to be an acceptable way for their children to receive adolescent healthcare.
Mechanical Circulatory Support
Authors: Tam Christopher W. , Shen Liang , Zeidman Amanda Dijanic , Srivastava Ankur , Ivascu Natalia S.
Published: May 2022

Mechanical life support therapies exist in many forms to temporarily replace the function of vital organs. Generally speaking, these tools are supportive therapy to allow for organ recovery but, at times, require transition to long-term mechanical support. This review will examine nonrenal extracorporeal life support for cardiac and pulmonary support as well as other mechanical circulatory support options. This is intended as a general primer and overview to assist nephrologist consultants participating in the care of these critically ill patients who often experience acute renal injury as a result of cardiopulmonary shock and from their exposure to mechanical circulatory support.
Bitcoin vs. Gold: Who is the Better Choice for Trading?
Authors: Li Can , Jiang Zixin , Liu Yinuo , Dang Yu , Wang Yuhan , Yu Rui
Published: May 2022

Venture capital led by Bitcoin and gold has become increasingly popular in the past several years, so the research of cryptocurrencies (such as Bitcoin) becomes deeper and deeper. Many researchers have studied the collaborative investment of bitcoin and gold, which is an expective portfolio. In this paper, the authors constructed a systematic model, achieving the combination among prediction, making strategies, solving profits, and evaluation. All the study in this paper is based on the given data and constructed model with accurate references.In this paper, the authors selected the long short-term memory model (LSTM) as the basis, then designed two models called the gold price prediction model (GPPM) and the Bitcoin price prediction model (BPPM) to estimate the price of both gold and Bitcoin, standing as a trader, not a “god economist”. The error analysis shows a good performance of GPPM and BPPM, and it gives the authors confidence to make strategies and calculate final profits (investment worth).Unambiguously, the final goal of this question is to maximize the total assets (profits), so the author set up a single objective optimization model (SOOM) called the trading strategy model (TSM). The total constraint conditions are divided into six directions, including the basic trading conditions, the evaluation of financial risk, and the difference between gold and Bitcoin. Additionally, the costumers with different trading risk tolerance will acquire different assets finally, which indicates that the prudent policy generally can lead to a better result. After calculation, the asset on 2021/9/10 is about 1.59×108 USD, a considerable number.The evaluation of TSM has two parts, one is the disturbance test. This test randomly sets that several days’ trading does not occur, then has a comparison between the original model prices and the prices after disturbance. The result proves that the strategy predicted by TSM is the best strategy. The result of the sensitivity test in section 4 finds the polynomial relationship between the assets and the transaction costs. Under current conditions, the final assets will decrease by 4.2% if the transaction costs of gold increase by 1%, and will increase by 2.1% if the transaction costs of bitcoin increase by 1%.Finally, the authors wrote a memorandum for different customers & traders. We sincerely hope the memorandum can help them in the near future.
The Experiences of Students in the Modular and Online Learning: A Phenomenological Study
Authors: M. Cortes Venus , C. Omongos May Gaselle , G. Quevedo Jerry Mae , Villarin Michelle , J. Yaun Karlene Kate , V. Segarra Marry Mael
Published: May 2022

This study aimed to determine the specific experiences of university students in terms of cognitive, social, emotional, and adversity skills in an online or modular mode of learning. The study utilized a phenomenology research design, and a semi-structured interview was conducted. Participants in the study were composed of students enrolled in online and modular learning who were asked to share their experiences elaborately. The analysis revealed that despite the differences in the learning modalities, the students similarly experienced the same significant adjustments and academic challenges. These experiences include the lack or limited access to information, concerns about the accessibility of the learning opportunities, lack of economic resources, time management concerns, communication with professors and classmates, and self-motivation and coping mechanisms. As an intended outcome, a feasible distance learning blueprint composed of possible courses of action that can be taken to achieve a more effective and feasible distance learning setup is made.
Sobre el uso de la metalepsis en régimen patafísico: “puesta en abismo”, fragmentación y aporías lógicas en los Gestes et opinions du docteur Faustroll, pataphysicien de Alfred Jarry
Authors: Piedade Nicolas
Published: May 2022

Este artículo propone analizar la transgresión de los umbrales narrativos en la novela de Alfred Jarry Gestes et opinions du docteur Faustroll, pataphysicien (1911), en la cual se exponen los principios de la patafísica, una ciencia paródica dedicada a las excepciones y a la exploración de las potencialidades de la imaginación. La hipótesis desarrollada en este trabajo se basa, pues, en la observación de que la valoración innovadora de la obra de Jarry supera ampliamente el corpus al que se reduce comúnmente. A través de la relación subjetiva de su personaje narrador, la iniciación patafísica representada en la novela se muestra capaz de configurar caminos representacionales atentos a proyecciones potenciales e inesperadas de significación hasta entonces prohibidas por los modelos de lecturas realistas o naturalistas de la realidad. Este artículo, por lo tanto, cuestiona los mecanismos movilizados en la construcción de una matriz ficcional concebida en forma de soporte pragmático para la ilustración y experimentación con los principios de la patafísica. Gracias al método de análisis de la recepción del personaje desarrollado por Vincent Jouve, esta reflexión examina en primer lugar la naturaleza de los mecanismos significantes utilizados por Alfred Jarry en la concepción del personaje del doctor Faustroll, agente e iniciador de la disciplina patafísica. La inestabilidad de su composición aparece así en un segundo movimiento en plena función de una práctica ficcional fuera de lugar, jugando con los procesos de fragmentación y refracción de los efectos de sentido. La metalepsis, figura narrativa examinada por Gérard Genette, se revela en un tercer paso como una entrada particularmente fructífera para un análisis narratológico de las transgresiones narrativas instauradas por el régimen de escritura patafísico.
Ama Ata Aidoo y la mirada estrábica negra: sátira y subversión en Our Sister Killjoy
Authors: Anaya Ferreira Nair
Published: May 2022

Ama Ata Aidoo es conocida por su abierto cuestionamiento del legado colonial británico en África, tema que aborda en una vasta obra narrativa, poética y dramática. En su primera novela, Our Sister Killjoy (1977), desafía los modelos representacionales europeos que niegan la historia del continente y continúan perpetuando estereotipos raciales como medio de exclusión. El objetivo de este artículo es examinar la forma en que mediante un uso magistral de la ironía y la sátira Aidoo desestabiliza tres géneros significativos de la tradición europea: el libro de viajes, la novela de formación y la novela epistolar. Planteo que la presencia de una voz narrativa asentada en la tradición oral africana, y que cuestiona de forma irreverente las contradicciones del discurso colonial universalista, genera un espacio satírico en el que la protagonista no puede más que asumir una postura ética y moral frente a la supuesta superioridad de la cultura europea. Mediante el tropo de la mirada estrábica, que saca de foco, invierte y subvierte la recepción de los valores europeos, Aidoo pone el dedo en la llaga en las paradojas de la poscolonialidad.
An Objective Analysis on the viability of underwater Turbines and their economic and environmental impacts
Authors: Abbasi Naved Ahmad , Kushaha Ajay Kumar , Shukla Dr. Shubham
Published: May 2022

Abstract: The energy crisis and climate crisis are two topics that have been a source of discussion, controversies and interest for global superpowers like America, European Union and China. One of the solutions to solve both is by using renewable source of energy, tidal energy and kinetic hydropower in this instance. This research paper shows an objective analysis on the viability of underwater turbines, their economic benefits, direct or indirect impact on the marine life and environment, their necessity, replaceability over conventional non-renewable and renewable energy sources, and different complications around its small as well as large scale usage. Furthermore, a study is also done to determine the favourable environment in which underwater turbines can be used and the estimated output energy that can be generated using mathematical tools. Also, different alterations are discussed to increase the power density in order to make the technology more feasible. Keyword: underwater turbines, tidal energy, renewable energy
Blockchain Technology Applications for Industry 4.0
Authors: Agarwal Darshika , Goel Satyam , Varshney Prafull , Kumar Dr. Ankit
Published: May 2022

Abstract: Blockchain: Industry 4.0 involves innovations with upcoming digital technologies, and blockchain is one of them. Blockchain can be incorporated to improve security, privacy, and data transparency both for small and large enterprises. Industry 4.0 is a synthesis of the new production methods that allow manufacturers to achieve their target more rapidly. Research has been conducted on various Industry 4.0 technologies like Artificial Intelligence (AI), Internet of Things (IoT), Big data, and Blockchain, and how they could create significant interruptions in recent years. These technologies provide various possibilities in the world of manufacturing and supply chain. Blockchain is a technology that has gained much recognition and can enhance the manufacturing and supply chain environment. Various fields now have fascinating insights into the advantages of blockchain. Several research articles on “Blockchain” and “Industry 4.0” from Google Scholar, Scopus, and other relevant sources are identified and reviewed for this study. This paper discusses the major potential of Blockchain in Industry 4.0. Various drivers, enablers, and associated capabilities of Blockchain technology for Industry 4.0 are discussed for insights. Different Industry 4.0 spheres/sub-domains for Blockchain technology realisation are also discussed. Finally, we have identified and studied fourteen significant applications of Blockchain in Industry 4.0. It is a range of new developments and hope for immense opportunities that are changing Industry 4.0. This technology would work to achieve amplified outcomes and work individually to enhance the process. Keywords: Education, Online Product learning, Ledgers, Bitcoin, Blocks, Smart Contracts, EOS.
A Survival Horror Game RIDE OUT
Authors: Shelare Mitali , Deshmukh Devyani , Shitole Dr. Sanjay
Published: May 2022

Abstract: In the Field of Software Engineering, Gaming is the fastest growing field and even more rapidly growing sector of game development the coming years are difficult to predict. Survival horror video games (SHVGs) are among the fastest-growing genres for independent video game developers. With horrific cinematic elements and fear-inducing characteristics, survival horror video games create a terrifying experience for users within a virtual environment. There are various game engines where we are able to create such amazing games such as in Unity3d, Unreal Engine, Game Maker, Godot, and more provide access to the identical technologies and tools available to large game developers. Unity3D Game Engine is an integrated development tool which is used to create interactive contents like video games, architectural visualization and real-time 3D animations. This paper studies about the Horror Survival game ‘RIDE OUT’ which we attempt to build for people to experience the horror and thrill within the virtual environment and hence the way it’s designed with horrific cinematic elements and fear-inducing characteristics. For the survival horror game, the plan goes: everything from building a scene and lighting, ending with battle mechanics and the design of game menus, create graphical effects, control the physical behavior of objects or even implement a custom AI system for characters in the game and much more. Keywords: survival horror video game, game development, AI, fear, game design, gameplay.
Fuzzy Logic Based MPPT Controller for a PV System
Authors: Navghare Nayan , Likhar Saurabh , Sutey Ritik , Bhoyar Kundan , Bagde Adesh , Bagde Kaustubh
Published: May 2022

Abstract: Maximum Power Point Tracking (MPPT) for photovoltaic system has been developed to maximize the produced energy. The output power of a photovoltaic (PV) module depends on the solar irradiance and the operating temperature, therefore it is necessary to implement the maximum power point tracking controller to obtain the maximum power of a PV system regardless of variations in climatic conditions. The output characteristic of a photovoltaic array is nonlinear and changes with solar irradiation and the cell’s temperature. Therefore, a Maximum Power Point Tracking technique is needed to draw peak power from the solar array to maximize the produced energy. In this work, the PV system is designed and simulated using MATLAB consisting of a solar panel array, MPPT controller, boost converter, voltage source convertor, a resistive load and grid. This thesis proposed the design and modeling of a fuzzy controller for tracking the maximum power point of a PV system. The performances of the solar PVs are analyzed with two cases, one with without MPPT controller and other is with the consideration of fuzzy based MPPT controller. These two cases are compared in terms of the output power efficiency, system dynamic response and finally the oscillations behavior.
A Review Paper on Design and Fabrication of Solar Operated Automatic Grass Cutter
Authors: Parikh Dr. R. H , Lonare Vicky , Patil Sanket , Diwate Radheshyam , Bhiwapurkar Rhutik , Saxena Sanjog
Published: May 2022

Abstract: A solar grass cutter could be a machine that uses rotating blades to cut a field. Power consumption becomes essential for future. Solar grass cutter could be a terribly helpful device that is incredibly simple in construction. We have made some changes within the existing machine to make its application easier at reduced price. Our main aim in pollution management is earned through this. The paper deals with solar grass cutter employed to chop the various grasses for the various application. Solar grass cutter could be a terribly helpful device that is incredibly simple construction. We have made some changes within the existing machine to make its application easier at reduced price. Our main aim in pollution management is earned through this. Unskilled person will operate simply and maintain the grass. The paper deals with solar grass cutter are employed to chop the various grasses for the various application.
Design The Circular Water Tank by Using the STAAD Pro Software
Authors: Mahdewa Prakash , Tirpude Mrs. Kirti Sahu
Published: May 2022

Abstract: Water tank are very useful for storage of water to involve the consumption of water we need to hold on to the capacity of water as much required. Now a day’s storage tank are suitable for all types of environment we live as old a civilized technique. Water is the common need for all the living organisms to survive. Portable water is imperative for good health of human beings. It is most important to supply portable water to every individual and every faction; hence it is very requisite to store water. Water is generally stored in the tanks the stored water is supplied to every faction through pipelines. In the project, we have planned and designed a circular reinforced cement concrete water tank. A circular tank is manually designed. It is further analyzed using the debut analysis software STAADPRO.
WFH on Duty Employee Attendance System
Authors: Sungar Aditya , Gaikwad Shradha , Shinde Nihal , Shirtar Mrunali , Pole Prof. Govind
Published: May 2022

Abstract: Automatic face recognition (AFR) technologies have seen dramatic improvements in performance over the past years, and such systems are now widely used for security and commercial applications. So Smart Attendance using Real Time Face Recognition is a real world solution which comes with day to day activities of handling students. The task is very difficult as the real time background subtraction in an image is still a challenge. To detect real time human face are used and a simple fast Principal Component Analysis has used to recognize the faces de-tested with a high accuracy rate. The matched faces are used to mark attendance of the student. Our system maintains the attendance records of students automatically. Manual entering of in logbooks becomes a difficult task and it also wastes the time. So we designed an efficient module that comprises of face recognition to manage the attendance records of students. Our module enrols the student’s face. Keywords: Automatic Face Recognition(AFR), Employee Attendance System, Attendance Management System(AMS)
The Theme of Fashion
Authors: Hatwar Dr. Nikita
Published: May 2022

Abstract: The aim of this paper is to study the domain of World Wide Web site development and also put forward a methodology to assist with this process. These methodologies have their proselytizers and those who decry the constraints and rigidity of prescriptive frameworks. The methodology presented here is unintended to be a panacea for the problems of web development; rather it is hoped it will provide a functional framework for guiding the process. The main study points out that the demographic profile of customers, the online seller of the product, the type of products to be purchased, and the characteristics of online shopping websites had an optimistic impact on the intention and online shopping behavior of the customers. The paper would help the marketers to implement ways and means to pull online shoppers. It will be helpful for the customer to understand the advantages and disadvantages of online shopping. Keywords: Proselytizers ,rigidity ,unintended ,demographic ,optimistic .
Face Recognition Door Lock System Using Raspberry PI
Authors: Singh Akash Deep
Published: May 2022

Abstract: Face recognition is a technique for recognizing or validating an individual's identification by looking at their face. Face recognition software can identify persons in photographs, videos, or in real time. During police stops, officers may use mobile devices to identify persons. Computer vision is a method for understanding how photos and movies are stored, as well as manipulating and retrieving data from them. Artificial Intelligence relies on or is mostly based on computer vision. Self-driving cars, robotics, and picture editing apps all rely heavily on computer vision. The software used is OpenCV Library which is useful to display and process the image produced by webcam. In this paper, we employ Haar Cascade Classifier in an image processing of user face to render the face detection with high accuracy. Keywords: OpenCV, Raspberry pi 4, Pi-Cam, Image Processing, Intelligent door lock.
Survey on Vulnerability of 4G/LTE Network Security and Improvements
Authors: Premchander Dr. Tudi
Published: May 2022

Abstract: Network security is viewed as a huge issue in our regular routine because of its going into many individuals' exercises like social movement, showcasing and business. Notwithstanding, the requirement for a safe and strong organization has expanded. The requirements for a secure organization have expanded because of the expanding dangers and programmers in our regular routine. In view of the ongoing insights, each second the quantity of supporters is expanding multiple times around the world which refers to the quick development of 4G/LTE organizations. It is seen that 80% of individuals universally have claimed 4G cell phones and the number is expanding during the new quite a long while. Besides, 4G/LTE is the groundwork of the 5G network, so high level security is required. From this point, this paper presents an overview of the enhancements that have been done as of late on 4G/LTE security and uncovers the shortcomings that still exist and that will permit specialists to concentrate and work on these shortcomings. Keywords: Attacks, 4G/LTE, vulnerability and security.
SPECIAL FEATURES OF CHANGES IN INDICATORS OF THE IMMUNE SYSTEM IN PATIENTS WITH ATHEROSCLEROSIS
Authors:   Vitebsk State Order of Peoples' Friendship Medical University, Prudnikov A.R. , Shchupakova A.N. ,   Vitebsk State Order of Peoples' Friendship Medical University
Published: May 2022

In patients with various forms of coronary heart disease (effort angina pectoris of tension II functional class (EAP II FC), myocardial infarction (MI)) an imbalance of immunological reactivity was revealed compared to practically healthy individuals, which was manifested by the increasing of the IL-6 concentration, IL-8, IgA, BAPNA-amidase activity, B-lymphocytes count, circulating immune complexes (CIC) and the decreasing of T-lymphocytes count, IgM and IgG concentration. It was also found that in patients with MI and EAP II FC, atherosclerosis was not limited to only one vascular region, lesions of the extracranial sections of the cerebral arteries, abdominal part of the aorta, arteries of the lower extremities were also recorded. The lesion of extracranial cerebral arteries in patients with EAP II FC was accompanied by the increase of neutrophil elastase activity, the number of СIC and the decrease of IgM concentration, IL-4, B-lymphocytes count, and in patients with MI it was accompanied by the increase of T-lymphocytes count and the decrease of B-lymphocytes count. When the abdominal aorta was affected, patients with EAP II FC had increased T-lymphocytes count, neutrophils and decreased IgM concentration, and patients with MI had increased T-lymphocytes count. The lesion of the lower extremities arteries in patients with EAP II FC was accompanied by the increase of T-lymphocytes count, sVCAM-1 adhesion molecules, the decrease of IgM concentration, BAPNA-amidase activity, and in patients with MI it was accompanied by the increasing of monocytes count, concentration of sVCAM-1 molecules and the decreasing of IL-6 concentration. At the same time, the development of multifocal atherosclerotic lesion (MFA) of peripheral arteries was accompanied only by the decrease of IgM concentration in patients with EAP II FC. The lesion of the anterior interventricular artery in patients with EAP II FC was combined with the increase of sVCAM-1 molecules concentration, and in patients with MI it was combined with the increase of IgG concentration and the decrease of IL-10 concentration. The lesion of the circumflex artery in patients with EAP II FC was combined with the increase of CIC concentration, TNF-α, and in patients with MI it was combined with increased IL-6 concentration. The lesion of the right coronary artery was not accompanied by any significant change in the immune system indicators in the studied groups of patients.
THE CLINIC AND TREATMENT OF ALCOHOL ADDICTION IN PATIENTS WITH AGGRESSIVE AND AUTOAGGRESSIVE BEHAVIOR (LITERATURE REVIEW)
Authors:   Vitebsk State Order of Peoples' Friendship Medical University, Alfiorau D.V. , Kirpichenka A.A. ,   Vitebsk State Order of Peoples' Friendship Medical University
Published: May 2022

This review article is an attempt to generalize and systematize the knowledge on the issues of affective disorders accompanied by the acts of aggression in the context of alcohol addiction. Achieving this goal required the consistent implementation of a number of tasks, and namely, a theoretical review of the material accumulated in recent years within the framework of the topic under study, its subsequent analysis and meaningful generalization. The methods of theoretical analysis and synthesis of the obtained material were used in the given work. The indicated topic of the review seems to be relevant due to the fact that, in modern psychiatry, narcology and related specialties, much attention is currently paid to aggressiveness as a stable personality trait to show aggression in all its forms. The reason for such close attention to aggressiveness is high probability of lethality in people of working age due to aggressive or autoaggressive actions. As living standards, well-being, and, subsequently, health care system improve, people are less likely to die of urgent pathology, most diseases respond to treatment and do not lead to sudden death of a patient. The situation is different with external causes of death, the lion’s share of them being caused precisely by aggressive actions in their various forms. The latter in one way or another are often interconnected with alcoholization of an individual: acts of aggression are either provoked by alcohol intoxication, or may result from an already formed dependence syndrome. The special features of the development, clinical pattern and treatment of affective disorders in alcohol dependence syndrome, accompanied by aggression and autoaggression have been considered in the present paper. As a result of the review, the main concepts of the development of affective disorders accompanied by the acts of aggressive behavior in the alcohol dependence syndrome have been identified; the main mechanisms of the occurrence of aggression in alcohol-dependent patients have been indicated; the key points of pharmacotherapy influence have been determined, and namely, the use of normotimic drugs, the most rational of which, in terms of the effectiveness-adverse reactions ratio, are oxcarbazepine and topiramate, as well as the use of drugs of the selective serotonin reuptake inhibitors (SSRIs) group, as the most relevant when choosing antidepressant therapy for alcohol-dependent patients. The effectiveness of the long-term therapy with disulfiram has been determined in cases of ensuring compliance control. The relevance of the proper use of lithium salts in the treatment of this group of patients has been designated.
Development and In-Vitro Evaluation of Itraconazole Loaded Nanoemulsion
Authors: Kumar Ashish , Kumar Ajay , Soni Abhishek , Devi Jyoti
Published: May 2022

Nanoemulsions are one of the major popular formulation systems in the pharmaceutical and cosmeceutical fields. Nanoemulsions are generally composed of a dispersed oil phase within a continuous aqueous phase. Itraconazole is an antifungal medication used to treat a number of fungal infections. It is in the triazole family of medications. Itraconazole, antifungal agent has poor bioavailability due to low aqueos solubility.  In this research preformulation study, Fourier transform infrared (FTIR) analysis studies was conducted for studying the compatibility. In preparation of Itraconazole loaded nanoemulsions from the ternary phase diagram ratio of surfactant to co-surfactant (Smix) was optimized with broad area. Optimized surfactant and co surfactant are accurately weighed and then vortexed for 5-10 min for Smix preparation. Particle size and value of PDI was found to be 159.21nm and zeta potential demonstrated the stability of prepared nanoparticles was found to be -15.9mv .Transmission electron microscope indicated a homogeneous distribution of small, spherical optimized Itraconazole loaded nanoemulsion formulation. These studies were aimed to improve the oral bioavailability of Itraconazole through nanoemulsions.

Keywords: Nanoemulsion, Itraconazole, Surfactant, cosurfactant, Nanoparticles