bluuebunny/crossref_metadata_2025 huggingface dataset:
Causes of Precocious Puberty in Children Referred to an Endocrine Clinic in Qazvin City, Iran From 2006 to 2018
Authors:   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Homaei Ali , Golmohammadi Roghayeh ,   Clinical Research Development Unit, Qods Hospital, Qazvin University of Medical Sciences, Qazvin, Iran., Saffari Fatemeh ,   Department of Pediatrics, School of Medicine, Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvi.
Published: March 2022

Background: Puberty is an essential milestone in a person’s life. Studies show that precocious puberty is more common in girls than in boys. Objectives: The aim of this study was to survey the causes of precocious puberty in children referred to the endocrine clinic in Qazvin city, Iran, from 2006 to 2018. Methods: This case-series study was performed from March 2006 to June 2018 on patients referred to the endocrine clinic of Qazvin University of Medical Sciences, Qazvin City, Iran, for precocious puberty. To diagnose premature puberty and find its causes, we surveyed sex steroids levels, thyroid function, and, if necessary, performed GnRH test. The patients’ height and weight were measured, and their BMIs (Body Mass Index) were calculated. Uterine ultrasound was performed for all girls. Additionally, brain MRI was performed for all boys and girls under age 6 with precocious puberty. X-ray of the left hand was performed to assess skeletal growth acceleration. Based on the type of puberty, the patients were divided into three groups: Central Precocious Puberty (CPP), Peripheral Precocious Puberty (PPP), and normal variant of puberty. The study data were collected from patients› electronic files and analyzed using SPSS 23. Results: Out of 724 cases, 642 (88.70%) were girls. The mean age of all children was 7.07 (95%CI: 6.99-7.15) years. About 70.5% of cases had CPP, 5% PPP, and 24.5% normal variant of puberty. Cases of Idiopathic Precocious Puberty (IPP), PPP, Neurogenic Central Precocious Puberty (NCPP), and premature pubarche were significantly higher in girls than boys (P<0.001). None of the boys had NCPP. Most girls had normal BMI, but boys were more obese. Mean bone age and bone age/age ratio were higher in girls with NCPP (P<0.001). Conclusions: In our study, most girls and boys had idiopathic precocious puberty, and none of the boys had brain lesions. About half of the cases were overweight or obese, indicating the role of obesity in increasing bone age and the onset of puberty.
Genetics of Legg-Calvé-Perthes Disease: A Review Study
Authors:   Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Asadollahi Samira , Neamatzadeh Hossein ,   Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Namiranian Nasim ,   Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Sobhan Mohammad Reza ,   Department of Orthopedics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Published: March 2022

Background: Legg-Calvé-Perthes Disease (LCPD), a juvenile hip disorder, is caused by impaired blood flow to the femoral head. In severe LCPD cases, the femoral head may develop a flattening deformity. Furthermore, if LCPD is diagnosed at the later stages, it causes early osteoarthritis of the hip. The etiology of LCPD is complex and embraces both genetic and epigenetic factors. Objectives: This review attempts to summarize the current knowledge on the role of these genetic variants in the incidence of LCPD. Methods: We searched for articles published in English using the special related search terms. Results: The genetic causes of this disease include mutations in the genes of thrombophilia factors, such as FV Leiden and anticardiolipin antibodies. The mutations of COL2A1, TRPS1, eNOS genes are the other causes. Moreover, the clinical symptoms of avascular necrosis may be indiscernible in patients with Gaucher’s disease or LCPD, and the differential diagnosis is a challenge. Conclusions: The results indicated that genetic testing may be useful in diagnosing and managing patients with juvenile hip disorders.
A Comparative Study of Professional Ethics, Depression, Anxiety and Stress in Athletic and Non-athletic Nurses During COVID–19
Authors:   Department of Sport Management, Faculty of Educational Sciences and Psychology, Payame Noor University, Tehran, Iran., Momenifar Fahimeh , Raji Amin ,   Department of Sport Management, Faculty of Educational Sciences and Psychology, Payame Noor University, Tehran, Iran., Jafarnezhadgero Amirali ,   Department of Management and Sports Biomechanics, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
Published: March 2022

Background and Aims: Nurses play an essential role in developing care, treatment, and community health during the outbreak of COVID-19. Also, because they are in the front line of dealing with this disease, they are more likely to suffer from psychological disorders and anxiety. Therefore, taking care of their mental health is very important. This study aimed to compare the level of professional ethics, depression, anxiety, and stress in athlete and non-athlete nurses working in selected hospitals in Tehran during COVID-19 disease in 1399. Methods: The sample size was 80 in the athlete group and 70 in the non-athlete group. Data collection tools included a demographic questionnaire, a depression, anxiety, and stress questionnaire(DASS-42), and 21 ethics questions in the nursing profession Jahanpour et al. Also, to analyze the data, SPSS v. 22 software and descriptive statistics methods (mean, standard deviation, etc.) and Clomogrov Smirnov and T-independent test were used in inferential statistics. Results: The results showed that depression, stress, and anxiety were higher in non-athlete nurses compared to nursing athletes (P<0001). The results also showed improved professional ethics in athlete nurses compared to non-athlete nurses (P<0001). Conclusion: Given the critical role of nurses in improving and promoting people's health in the actual situation of COVID–19 disease, encouraging them to exercise according to a regular schedule with the support of sports coaches is considered a health priority.
Metal-carbon eutectic high temperature fixed points for in-situ calibration of radiation thermometers
Authors: Failleau G. , Fleurence N. , Beaumont O. , Razouk R. , Hameury J. , Hay B.
Published: March 2022

The diffusivimeter of LNE has been modified by improving the inductive furnace used to heat the tested specimens in order to extend the operating temperature range up to 3000 �C. The temperature of specimen is one of the tricky parameters to be measured to ensure the relevance of the thermal diffusivity measurement and the associated uncertainty. At high temperature, radiation thermometers are used to determine the temperature of the specimens at which the thermal diffusivity measurements are performed. In addition to the periodic calibration of the radiation thermometers performed outside the experimental facility with black body sources, LNE proposes an in-situ verification method based on miniature high temperature fixed-point cells filled with metal-carbon eutectic alloys in order to detect and correct potential drift of the radiation thermometers between two out-of-process calibration operations. The proposed method enables high repeatable and reproducible temperature measurements on eutectic fixed-points (Pd-C, Pt-C and Ir-C) distributed in the range from 1500 �C to 2300 �C.
The elastic and thermodynamic properties of TbAl and DyAl under high pressure
Authors: Liu Lili , Chen Cai , Chen Liwan , Wen Yufeng
Published: March 2022

The elastic and thermodynamic properties of TbAl and DyAl under high pressure and temperature are investigated using the density-functional theory (DFT) and the density-functional perturbation theory (DFPT) within the quasi-harmonic approximation (QHA). The calculated lattice and elastic constants at ground state (0 GPa and 0 K) are in agreement with the experimental data and previous theoretical results. Finally, when the pressure is given, all the thermodynamic quantities except for the bulk modulus increase with temperature, but the increase of the thermal expansion coefficient and the heat capacity with temperature becomes smaller. Besides, the effects of pressure on the elastic constants and the thermodynamic quantities are opposite with those of the temperature on them for TbAl and DyAl.
Thermal expansion, heat capacity and Gr�neisen parameter of grossular at high temperature and high pressure
Authors: Su Chang , Liu Yonggang
Published: March 2022

The thermodynamic properties of grossular garnet (Ca3Al2Si3O12) were determined as a function of pressure and temperature in this study. With a numerical iterative procedure, the unit-cell volume, adiabatic bulk modulus, thermal expansion, heat capacity, and Gr�neisen parameters of grossular up to 25 GPa, 2000 K were extracted from experimental elastic wave velocities at high temperature and high pressure conditions. The calculated unit-cell volume and adiabatic bulk modulus agree well with the previous studies. The results imply that our calculated thermal expansion, heat capacity, and Gr�neisen parameters of grossular are all decrease with elevated pressure, and both thermal expansion and heat capacity show nonlinear pressure dependences. On the other hand, the Gr�neisen parameter shows a linear pressure dependence. The pressure derivative of thermal expansion display a regularity increase with temperature, while the pressure derivatives of heat capacity and Gr�neisen parameters display a rapid decrease at low temperature and a slow growth above ~1000 K.
Thermophysical characterization of materials at high temperatures by solving inverse problems within the Bayesian framework of statistics
Authors: Masson Philippe Le , Orlande Helcio R. B.
Published: March 2022

Inverse heat transfer problems deal with the estimation of parameters or functions appearing in the mathematical formulation of problems in thermal sciences, by utilizing measurements of dependent variables of the formulation. Inverse problems are extremely useful for the indirect measurement of thermophysical properties, in particular for challenging situations involving high temperatures, where coupled multi-physics phenomena and nonlinearities must be taken into account. In this paper, basic inverse problem concepts are reviewed. Solution techniques within the Bayesian framework of statistics are briefly described and applied to two inverse problems related to the authors� experience on the estimation of thermophysical properties at high temperatures.
Composition and dimension dependence of melting temperature in bimetallic nanoalloys
Authors: Goyal Monika
Published: March 2022

The phenomological model for cohesive energy of metallic nanomaterials is extended to investigate the variation in thermodynamic properties of bimetallic nanostructures. The systematic investigation of variation in melting temperature of bimetallic nanomaterials is done to study the impact of size, composition and dimension. Decrease in melting temperature of bimetallic nanoalloys is found as size of nanoalloy decreases. It is noted that for bimetallic nanoalloys of same composition and having same size, the melting temperature varies on the basis of dimension of nanoalloy in the sequence such that (Tmn)nanofilms> (Tmn)nanowires> (Tmn)nanoparticles. The present predicted results obtained from extended model are compared with the simulated and experimental results available. Good consistency is observed between the compared results which justify the present model theory.
Investigating Human Resource Practices and its Impact on Employee Performance in Selected Banks in the Philippines
Authors: Cruz Mylene M. dela , Cabaluna Alan Y.
Published: March 2022

This paper investigates the impact of human resource practices (HR) on employee performance in selected banks in the Philippines. Survey questionnaires were deployed among employees from selected banks in the Philippines to assess the implementation of HR practices such as recruitment and selection, training and development, employee relations, and compensation and benefits in their respective organization. The survey questionnaire also aids in determining the bank employees’ evaluation of their accomplishment in terms of extent, timeliness, and quality. Data were analyzed and interpreted using mean, frequency, percentage, multiple linear regression, and correlation. Results showed that implementation of HR practices helped bank employees meet the accomplishment expected from them with regard to extent, timeliness, and quality. Meanwhile, among the four HR practices, training and development and compensation and benefits have significant impact on employee performance. Included in the identified improvement strategy, is for the bank organization to realign their HR practices to adapt during uncertain times, for instance, this pandemic. Realignment should focus on shift to online/ virtual conduct of recruitment and selection to ensure maintenance of adequate workforce; provision for online courses, trainings, and seminars for employees’ continuous learning development; having programs/ activities in place to be able for the employees to be reconnected with their colleagues and the organization; and possible early release of compensation to keep the employees financially able.
Examining the Factors Affecting Accounting Prudence
Authors: Idrus Mukhammad , Fatimah Siti , Mukhtar Afiah , Salam Karta Negara
Published: March 2022

This study examines the effect of managerial ownership, firm size, leverage, and growth opportunities on accounting prudence. This type of research includes causal research using quantitative methods. The population in this study were all mining companies listed on the BEI, as many as 28 companies. The sample in this study was determined by purposive sampling, so the full selection was 50 data from 10 financial statements of mining companies for five years. Secondary data was collected through the Indonesia Stock Exchange website and analyzed using Multiple Regression Analysis with the Ordinary Least Square model using the Eviews Version 12 software. The results found that managerial ownership positively and significantly affected accounting prudence. Meanwhile, firm size and leverage have no significant positive effect on accounting prudence. Meanwhile, the growth opportunities variable has a negative and significant impact on accounting prudence. The suggestions given by the author for further research are expected to consider other factors outside of this research that can affect accounting prudence such as litigation risk, taxes, and public ownership and can expand objects to other sectors and extend the research period to provide better results and more accurate.
Inspectorate Auditor Performance Improvement Reference
Authors: Rismayadi Budi
Published: March 2022

Auditor performance can not be separated from the behavior of auditors in carrying out their duties. This study examines the relationship between professionalism, leadership style, organizational commitment, and work motivation on auditor performance. The research approach used in this study is a quantitative descriptive approach. This study involved 41 auditors at the Karawang Regency Inspectorate. The data analysis technique in this study used Partial Least Square (PLS). The study results found that professionalism positively and significantly affected auditor performance. There is no significant effect between leadership style on auditor performance. There is a significant positive effect between organizational commitment to the auditor's performance and the auditor's work motivation having a positive impact on the auditor's performance. The results of this study illustrate that this indicates that the auditor is more professional in his work and has the motivation to perform specific tasks in achieving a goal. The organization is not wholly and part of those who work as auditors. Auditors who have reason in carrying out their duties can provide good results in carrying out their responsibilities because basis can provide enthusiasm that will affect the performance of auditors.
Pattern of Absorption of the Provincial Budget for the Special Capital Region (DKI) of Jakarta
Authors: Digdowiseiso Kumba
Published: March 2022

The failure of the budget absorption target in the Regional Apparatus Organizations (OPD) of Capital Region (DKI) of Jakarta resulted in the loss of the benefits of spending because the funds allocated were not fully utilized. If the budget allocation is efficient, then the state can optimize the limited sources of funds to fund strategic activities. This study aims to examine the budget planning documents, administrative documents, procurement of goods, and budget execution affect the absorption of the budget. This study uses a quantitative approach, namely a research method based on the philosophy of positivism. The population in this study is the entire province of DKI Jakarta, which is as many as 23 OPD. Sampling in this study using a purposive sampling technique. Research as the whole population was used as a sample of 69 PPK-OPD people, OPD treasurers, and financial staff also called the population sample (census). Hypothesis testing is done by testing variance-based SEM or Partial Least Square (SEM-PLS) with the Smart pls 3.0 program. The study results found that planning documents and administrative documents had a positive but not significant effect on budget absorption. Meanwhile, the procurement of goods/services and the implementation of the budget have a positive and significant impact on budget absorption. This study suggests that the DKI Jakarta Provincial Government, to increase budget absorption, is expected to give serious attention to the problem of budget absorption by continuously improving the budget planning process in terms of documents and administration, starting from the preparation of the RKA to the Determination of the Regional Budget. Accelerate the budget implementation process by issuing Treasury Official Decrees on time, not delaying work, timely administrative completion processes in implementing the budget referring to the approved DPA and Cash Budget. Carry out the process of procuring goods and services by applicable laws and regulations.
Examining Factors Affecting the Accountability of the Performance of Regional Apparatus Organizations
Authors: Ernawati Dyah Poespita
Published: March 2022

The purpose of this study was to obtain empirical evidence of the influence of competence, leadership style, organizational culture, use of technology, and reporting systems on the performance accountability of government agencies in OPD Sumedang Regency. This research approach uses a scientific method which is a theoretical structure to form a hypothesis. It then uses facts or empirical data to test the theory to conclude or be conclusive. The data collection technique in this study used a questionnaire distributed directly to the OPD of the Sumedang Regency. The population in this study were all OPD Sumedang Regency, as many as 31 OPD. Sampling in this study using the purposive sampling technique. Respondents in this study were the head of financial administration and administrative staff. So, the total sample of this research is 31 x 2 apparatus = 62 OPD apparatus in Sumedang Regency. Data processing technique using SEM method based on Partial Least Square (PLS). The study results found that competence, leadership style, organizational culture, and technology had a positive and significant effect on the accountability of government agencies' performance at OPD Sumedang Regency. At the same time, the reporting system has a positive but not significant impact on the Performance Accountability of Government Agencies at OPD Sumedang Regency.
Islamic Financial Management Practices and Business Performance in Small Industrial Companies
Authors: Sirat Abdul Hadi
Published: March 2022

This study aims to examine the effect of Islamic financial literacy, investment decisions, funding decisions, and working capital on business performance in small halal industries (IK) in Ternate. The respondents involved were 53 IK. This research is quantitative and descriptive. Data was collected using online questionnaires, namely, google forms and interviews. This study uses a simple random sampling technique in producing the research sample. The data analysis technique used multiple regression models and research hypothesis testing. The results showed that the financial literacy of IK owners was moderate and had no effect on business performance. Investment decisions of IK players are relatively good and do not affect business performance. The funding decisions of halal IK actors are rather good and impact business performance. The findings of this study are that working capital is classified as very good and has a positive and significant effect on IK business performance. Furthermore, working capital has a dominant impact on business performance, as seen from the bear value of the t table compared to 3 (three) other variables. This research implies that it can be used as a support for strategic decisions regarding the development of IK in the city of Ternate, that IK owners need to develop financial literacy, investment decisions, and appropriate funding decisions as well as manage the company's working capital effectively and efficiently so that the achievement of business performance is better.
The Chain of Business Failures Village Owned Enterprises Gain Profits and Create Community Welfare
Authors: Suwito Suwito
Published: March 2022

This study aims to uncover the chain of Village Owned Enterprises (BUMDes) business failures in the West Halmahera Regency. BUMDes business is a village government business that is run to achieve the goals of profit and society welfare. Empirical facts show that after the Village formed BUMDes and made a sizeable Equity Participation in BUMDes, what happened was that BUMDes BUMdes businesses experienced suspended animation. As a result, until now, the existence of BUMDes has not been able to contribute to Village Original Revenue and improve the welfare of rural communities as expected by the Village and the Community. The researcher uses a qualitative approach with the Transcendental Phenomenology method to achieve this goal. The research information includes elements of the village government, BUMDes managers, and village communities who have been in contact with BUMDes. The study results provide evidence that the failure of the BUMDes business is caused by the high conflict of interest of the village head and the indifference of the Village Consultative Body (BPD) towards BUMDes. This research contributes both theoretically to the development of regional financial management science and being information material for the West Halmahera Regency Government to make it easier for local governments to break the chain of failure of the BUMDes business.
Constructive Termination of Employment by Indonesia Companies: A Comparative Study
Authors: Kasih Desak Putu Dewi , Satyayuda Dananjaya Nyoman , Sudiarawan Kadek Agus , Raksita I Putu Bimbisara Wimuna
Published: March 2022

This research aims to identify the regulation and dispute resolution regarding constructive termination of employment by a company in the perspective of Indonesian Labor Law. This research also compares the constructive termination of employment by companies based on International Law and Japan Labor Law. This is normative legal research with a statutory approach, conceptual approach, and also comparative law approach. The result shows that the constructive termination of employment has not been specifically regulated in the Indonesian Labor Law system, hence it becomes an exploitation gap that is used by companies to be able to terminate employment relations without protecting the workerâ€™s right. The dispute resolution mechanism in terms of constructive termination of employments still refers to the provisions of the Industrial Relations Dispute Settlement Law, namely through bipartite negotiations, tripartite, and industrial relations courts. The constructive termination of employment has been substantively regulated in the ILO Convention C-158 concerning the Termination of Employment, which regulated in Article 4 to Article 6. Further in Japan, the constructive termination of employment is regulated in the Japan Labor Union Act, Act Number 174 of 1949 in Article 7 paragraph (i), (iii), and (iv) with its national enforcement.
The Regulation of Straf Minima For Minors As Manus Ministra In The Crime Of Terrorism
Authors: Darma I Made Wirya , Bunga Dewi
Published: March 2022

In cases of terrorism involving minors, it must be understood that they are victims. Terrorism eradication regulations, which do not provide the possibility for diversion for children as manus ministra, need to consider the condition of the minors' psychological growth, which, of course, still has the potential to be of good value if properly nurtured. This study aims to determine the arrangement of the straf minima of minors as manus ministra in the crime of terrorism. The research method used is juridical normative or literature research related to normative legal substances, to find the truth based on scientific logic from a normative perspective by examining library materials or secondary data consisting of primary legal materials and secondary legal materials. The results of this study show that there are differences in the imposition of criminal sanctions for criminal acts of terrorism committed by a minor, namely Articles 19 and 24 of the Law on the Eradication of Criminal Acts of Terrorism. The Law on Combating Criminal Acts of Terrorism does not apply to minors who are involved in terrorism. This means that the general straf minima contained in the Criminal Code are used, namely for imprisonment to be imposed for at least 1 day. Article 19 and Article 24 of the Law on Combating Criminal Acts of Terrorism also abolish the provisions of the death penalty and life imprisonment for a person who is not yet 18 years old.
Formulation of Customary Criminal Law in Future Criminal Code and Legal Enforcement in Indonesia
Authors: Rusdi Antara Gede Eka , Budiana I Nyoman , Sadnyini Ida Ayu
Published: March 2022

The pros and cons were debated in limiting national legal substance with full recognition of Customary Criminal Law in the bill of Criminal Code and its future enforcement. On the other hand, there are arguments against the inclusion of Customary Criminal Law in the Criminal Code and the resulting disparities in legal enforcement caused by some Judges’ ignorance of judging customary criminal cases settled with the imposition of customary sanctions, which resulted in an unjust situation. This article aims to serve as a legal academic framework for establishing, identifying, and analyzing the formulation of Customary Criminal Law into the Indonesian Criminal Code, as well as to contribute to the discussion of judges’ roles in sentencing customary criminal cases, which they should determine and judge based on customary law. This article demonstrated the use of normative legal research in conjunction with statutory law, legal conceptual, and philosophical approaches to law. This article discovered that: first, several issues concerning the formulation of Customary Criminal Law into several national Bills of Criminal Code were debatable; second, it also cannot be enacted due to conflicting contexts with Criminal Law principles, unwillingness, and an ambiguous law-making process. Furthermore, the prospect of including the Customary Criminal Law in the Bill of Criminal Code is based on various justifications and legal needs that reflect the diverse local genius that still exists and adheres to Pancasila law principles. Additionally, it relates to a proposed new paradigm that Judges and other legal enforcers should adopt when enforcing Customary Criminal Law in any criminal customary case.
Reformismo em desencanto: as políticas públicas e o estado no capitalismo
Authors: Silva Wagner Pires da , Barbosa Erlene Pereira , Maciel Paulo Henrique Freitas , Souza Ana Carmita Bezerra de
Published: March 2022

Os primeiros anos do século XXI foram marcados pelas tentativas de reforma do Estado, em diversos países da América Latina. As políticas aplicadas representaram um avanço para os trabalhadores, no entanto não foram capazes de modificar sensivelmente as relações entre capital e trabalho, bem como, nos mais diversos países, os governos tem sido apeados do poder, por vias democráticas ou não. Por que as reformas do Estado não conseguiram modificar de modo permanente a situação da classe trabalhadora? Essa é a pergunta que o presente trabalho procura responder, por meio de um levantamento bibliográfico sobre a concepção de Estado em Marx, recorrendo assim a reflexão marxista, para compreender que os esforços por reformar o Estado e garantir um capitalismo mais humano, bem como uma emancipação das classes trabalhadoras sem contrariar a lógica do sistema capitalista terminam por perpetuar a exploração, ao apresentar como conquistas, algumas concessões feitas pela burguesia, concessões essas que ao primeiro sinal de crise são suspensas. O objetivo da pesquisa é mostrar que o Estado no capitalismo é irreformável, tendo, portanto, que ser substituído pelos trabalhadores por uma nova forma de organização para que a exploração do homem pelo homem possa ser interrompida.
Realismo literario y pedagogía socialista: a propósito de los ensayos de Gyögy Lukács sobre Gorki y Makarenko
Authors: Vedda Miguel
Published: March 2022

El artículo se ocupa de examinar la compilación de ensayos de György Lukács Der russische Realismus in der Weltliteratur (1946, 1951) –en particular los estudios dedicados a Gorki y Makarenko– con vistas a analizar algunos temas centrales: las bases metodológicas de una crítica literaria marxista, la discusión sobre la función social y humana de la literatura, la relación entre literatura y vida social, los principios de una pedagogía y una ética marxistas.
A educação integral no ensino médio brasileiro: proteção integral ou formação humana?
Authors: Silva Katharine Ninive Pinto
Published: March 2022

O artigo traz resultados de pesquisas realizadas pelo Grupo GESTOR – Pesquisa em Gestão da Educação e Políticas do Tempo Livre em torno da temática da Educação Integral no Ensino Médio Brasileiro. O objetivo geral do artigo foi debater o contexto atual em torno da Educação Integral no Ensino Médio. Através de uma pesquisa com palavras-chave (integral, integrada, ensino médio) foi feita uma seleção de documentos e posterior análise através da categorização por temas, conforme a concepção dialógica de Bakhtin (1997). Os resultados da pesquisa indicam que a Educação Integral, no contexto do Ensino Médio, vem sendo utilizada para a disputa pela captura da subjetividade dos jovens, pelo Capital, bem como para compensar a ausência de políticas públicas em torno da projeção integral, diante do avanço do ideário neoliberal, na perspectiva de guarda e controle dos jovens.
O despertar do dragão: o nascimento do imperialismo chinês
Authors: Maestri Filho Mário José
Published: March 2022

O presente artigo analisa as raízes do atual conflito USA X China. Aborda a conquista do poder pelo PCC, em 1949; o caráter camponês e escassamente proletário daquela revolução; os primeiros anos da revolução e o I Plano Quinquenal; o lançamento,  fracasso e as consequências do Grande Salto Adiante (1958-60); a contraofensiva e vitória de Mao Tsé-Tung e de sua facção quando da Grande Revolução Cultura Proletária (1965-69); os  projeto, desdobramentos e crise da Revolução Cultural; o fortalecimento da economia mercantil na China,; a morte de Mao Tsé-Tung; o retorno de Deng Xiaoping e o fim da Era Maoísta (1949-1978.).
Procedure for the Design of Agrotourist Products to Contribute to Local Development
Authors: Pérez Anzardo Lisbet Eunice
Published: March 2022

Tourism products constitute an element of high incidence in the economies of all countries due to their multiplying nature and their potential as exportable resources. In addition, they represent a significant variable within the study of marketing, since they are the main component of the offer of any destination and around which revolve the rest of the policies that operational marketing follows. Regardless of the type of tourist product that is offered, it must be taken into account to satisfy the needs of tourists so that they can enjoy a unique experience that identifies and differentiates it from other products. The following article proposes, based on current trends, a procedure for the design of agro-tourism products that can be used in a general way, for the creation of tourism products. It comprises four structured phases in the form of a system and a fifth evaluation phase, which is present in the previous ones; which allows the correct planning, development, management and promotion of nature tourism products and their different segments, so that they can be inserted in a competitive market and are not only optional for the Sun and Beach modality, which is the one that is the most influx of tourists attracts globally. It also has in one of its stages the validation through the criteria of specialists of the design, importance and relevance of the tourist product, depending on its quality.
Evaluación de vulnerabilidad sísmica apoyada en tecnologías de información geográfica
Authors:   Universidad Nacional de Chimborazo, Velasteguí Cáceres Luis Alejandro , Velasteguí Cáceres Julia Desiree , Chamorro Sevilla Hernán Eriberto
Published: March 2022

El presente libro Evaluación de vulnerabilidad sísmica apoyada en tecnologías de información geográfica, se destina a ser utilizado de modo particular en la enseñanza en general y de manera general, como libro divulgativo que trata tanto de las ciencias humanas como las de educación. Se ha pretendido elaborar un libro que pueda ser leído por cualquier persona sin formación técnica en la materia y lograr que, a través de su lectura, pueda entender el comportamiento del ser humano en las diferentes áreas y situaciones que conlleva su desarrollo y educación. Su carácter divulgativo favorecerá su aprovechamiento por jóvenes, pero también por personas de todas las edades que sientan interés por los temas sociales y educativos.
THE PROSECUTORIAL MONOPOLY
OF THE SLOVAK PUBLIC PROSECUTION SERVICE: NO ACCESS TO JUSTICE FOR THE INJURED PARTY?
Authors: Šramel Bystrík , Klimek Libor
Published: March 2022

The recodification of criminal law realised in the Slovak Republic in 2005 brought several new elements to criminal proceedings. One of them was the expansion and significant strengthening of the discretion of the public prosecutor in criminal proceedings. However, this authority of the public prosecutor’s office is, in many cases, perceived sensitively and controversially in Slovak society, especially in connection with many cases and scandals, when the prosecutor simply stated that ‘the act did not occur’. One of the related problems is the fact that the injured party in the Slovak Republic has essentially no powers that would, independently of the prosecutor’s office, ensure the control of the prosecutor’s discretionary powers directly through an independent and impartial court. This situation also stems from the fact that the public prosecutor’s office has a prosecution monopoly in Slovak criminal proceedings. However, the current prosecution monopoly of the prosecutor’s office is not a rational consequence of its historical development in our territory but a consequence of the coup d’état in 1948 and the subsequent onset of the communist regime. The possibility for other entities (e.g., the injured party) to exercise their rights through criminal law institutions has thus been minimised.

Based on the above, the aim of this paper is to examine the existing scope of the discretion of public prosecutors in Slovakia, analyse the possibilities of controlling the exercise of these powers, and answer the question of how to improve the current possibilities of the control.
The Right to a Fair Trial and the Right to a Fair Decision in Slovak Criminal Law
Authors: Vaško Adrián , Ivor Jaroslav
Published: March 2022

Background: The right to a fair trial, resulting from international documents, the Constitution, and the legal order of the Slovak Republic, is confronted in terms of content with the requirement and reasonable expectation of fair decision-making in criminal proceedings. The paper seeks to define the concept of justice and its procedural and substantive aspects as the course but also as the result of criminal proceedings. Criminal proceedings are always aimed at resulting in a certain decision of the body active in criminal proceedings and the court. Criminal proceedings without a decision would not make sense. The content and quality of the decision, especially from the point of view of legality and fairness, reflect the legal culture of the state and its bodies.

Methods: The scientific methods used in this article are legal comparison, content analysis of websites, functional analysis of legal acts, and analysis of the decisions of many international and national courts.
Results and Conclusions: Justice in law has an ambiguous meaning from a legal-theoretical point of view, mainly because it is a concept with a high degree of abstractness. No legal-theoretical definition of justice can be found in the case-law of Slovak as well as Czech courts. In Slovak case law, the term justice occurs exclusively in the context of the right to a fair trial, i.e., at the procedural level. However, as already mentioned, the Criminal Codes also refer in several places to the term ‘fair decision’ as the result of criminal proceedings, i.e., the substantive level of justice. It should be recalled here that each individual has his or her own autonomous idea of justice and his or her own criteria for evaluating other people’s actions. It is almost impossible to reach a consensus on guilt and punishment in an individual criminal decision with the public and especially with the parties to the proceedings, i.e., the injured party and the accused. Especially, individual justice in the decision is debatable, especially in cases of diversions or in the application of the principle of opportunity.
Rancang Bangun Sistem Informasi Geografis Pemetaan Lokasi Badan Usaha Milik Desa Berbasis Android
Authors: Kurniadi Dede , Setiawan Ridwan , Nugraha Agus
Published: March 2022

BUMDes atau Badan Usaha Milik Desa merupakan salah satu lembaga pemerintah desa bidang ekonomi yang dapat meningkatkan perekonomian dan atau dikelola oleh masyarakat desa. Dinas Pemberdayaan Masyarakat dan Desa (DPMD) yang menjadi fasilitator pembinaan dan evaluasi dalam perkembangan BUMDes. Dengan adanya kesulitan mengunjungi lokasi-lokasi BUMDes dan sistem yang dapat menggambarkan perkembangan BUMDes menyebabkan pihak dinas terkait sulit dalam melakukan pembinaan. Tujuan dari penelitian ini adalah ingin menggambarkan status perkembangan BUMDes yang ada di Kabupaten Garut. Melalui metodologi Rational Unified Proccess (RUP) penelitian ini dilakukan dengan tahapan; Inception, Elaboration, dan hanya pada Contruction dengan  pemodelan Unified Modelling Language (UML). Peneletian ini menghasilkan sistem yang dapat memberikan informasi geografis berupa pemetaan lokasi keberadaan BUMDes, informasi sisa hasil usaha dan status keaktifan yang dapat digunakan untuk mengetahui perkembangan BUMDes yang ada di Kabupaten Garut.
Istutuspäällikkö Gaddin julkiset matkaraportit 1763–1765
Authors: Kyläkoski Kaisa
Published: March 2022

Artikkelissa tarkastellaan Inrikes Tidningarissa julkaistuja raportteja Pehr Adrian Gaddin (1727–1797) matkoista Suomessa vuosina 1763–1765. Tekstit sekä rikastavat käsitystä Gaddin toiminnasta istutuspäällikkönä että antavat esimerkin mahdollisesta julkisuuden käytöstä vapaudenajan lopun Ruotsissa.
Yliopistosta erottaminen ja siihen liittyvä liikkuminen Turun ja Uppsalan välillä 1600-luvulla
Authors: Välimäki Mari
Published: March 2022

Ruotsin yliopistoissa oli käytössä uudella ajalla erotusrangaistus opiskelijoiden ojentamiseksi. Erottaminen ei ollut ainoastaan akateemisen maailman rangaistusmuoto, vaan se perustui aikakauden Euroopassa yleiselle ajatukselle, jonka mukaan yhteisöön sopeutumattomat, vakavia rikoksia tehneet ja tapojaan muuttamattomat yksilöt tuli poistaa yhteisöstä. Karkottamista käytettiin rangaistuksena vakavissa rikostapauksissa pääasiassa kaupungeissa. Karkotetut erotettiin yhteisöstään, sillä he olivat rikkoneet yhteisön normeja ja olivat uhka muiden hyvinvoinnille ja yleiselle järjestykselle. Karkotus oli häpeärangaistus, joka vaikutti negatiivisesti yksilön kunniaan ja maineeseen. Kunnia ja maine puolestaan määrittelivät yksilön asemaa varhaismodernissa yhteisössä: kunniallinen ihminen noudatti yhteisönsä normeja. Hän sai esimerkiksi toimia todistajana oikeudenkäynneissä ja hänen kanssaan nautittiin yhteisiä juhlamaljoja. Kunniaton ihminen joutui yhteisön ulkopuolelle, eikä häntä päästetty osalliseksi kunniallisten ihmisten toimista. Kaupungista karkottaminen oli vakavampi rangaistus kuin erottaminen, jota käytettiin myös yliopistojen ulkopuolella rangaistuksena muun muassa käsityöläisammattikunnissa, mutta näissä rangaistusmuodoissa oli paljon samaa: yhteisön ulkopuolelle sulkeminen rangaistuksena yhteisten normien rikkomisesta. Useimmiten erotusta käytettiin nuorukaisten eli kisällien ja opiskelijoiden ojentamiseksi vakavien rikkeiden seurauksena. Tässä artikkelissa ruotsalaisten yliopistojen kulttuurihistoriaa tarkastellaan erotusrangaistuksen ja liikkumisen näkökulmista.
The Space-Exposed Kombucha Microbial Community Member Komagataeibacter oboediens Showed Only Minor Changes in Its Genome After Reactivation on Earth
Authors: Santana de Carvalho Daniel , Trovatti Uetanabaro Ana Paula , Kato Rodrigo Bentes , Aburjaile Flávia Figueira , Jaiswal Arun Kumar , Profeta Rodrigo , De Oliveira Carvalho Rodrigo Dias , Tiwar Sandeep , Cybelle Pinto Gomide Anne , Almeida Costa Eduardo , Kukharenko Olga , Orlovska Iryna , Podolich Olga , Reva Oleg , Ramos Pablo Ivan P. , De Carvalho Azevedo Vasco Ariston , Brenig Bertram , Andrade Bruno Silva , de Vera Jean-Pierre P. , Kozyrovska Natalia O. , Barh Debmalya , Góes-Neto Aristóteles
Published: March 2022

Komagataeibacter is the dominant taxon and cellulose-producing bacteria in the Kombucha Microbial Community (KMC). This is the first study to isolate the K. oboediens genome from a reactivated space-exposed KMC sample and comprehensively characterize it. The space-exposed genome was compared with the Earth-based reference genome to understand the genome stability of K. oboediens under extraterrestrial conditions during a long time. Our results suggest that the genomes of K. oboediens IMBG180 (ground sample) and K. oboediens IMBG185 (space-exposed) are remarkably similar in topology, genomic islands, transposases, prion-like proteins, and number of plasmids and CRISPR-Cas cassettes. Nonetheless, there was a difference in the length of plasmids and the location of cas genes. A small difference was observed in the number of protein coding genes. Despite these differences, they do not affect any genetic metabolic profile of the cellulose synthesis, nitrogen-fixation, hopanoid lipids biosynthesis, and stress-related pathways. Minor changes are only observed in central carbohydrate and energy metabolism pathways gene numbers or sequence completeness. Altogether, these findings suggest that K. oboediens maintains its genome stability and functionality in KMC exposed to the space environment most probably due to the protective role of the KMC biofilm. Furthermore, due to its unaffected metabolic pathways, this bacterial species may also retain some promising potential for space applications.
Persistent Autonomic Engagement and Cardiac Control After Four or More Years of Autonomic Regulation Therapy Using Vagus Nerve Stimulation
Authors: Libbus Imad , Premchand Rajendra K. , Sharma Kamal , Mittal Sanjay , Monteiro Rufino , Amurthur Badri , KenKnight Bruce H. , DiCarlo Lorenzo A. , Anand Inder S.
Published: March 2022

Introduction

Although heart failure (HF) outcomes have improved dramatically with the use of guideline directed medical therapy and implantable devices, the overall prognosis of patients with HF and reduced ejection fraction (HFrEF) remains poor. Autonomic Regulation Therapy (ART) using chronic vagus nerve stimulation (VNS) has been evaluated in the ANTHEM-HF study, using changes in heart rate (HR) dynamics as a biomarker of autonomic nervous system engagement and cardiac control to guide VNS titration. ART was associated with sustained improvement in cardiac function and HF symptoms in patients with HFrEF and persistent HF symptoms despite guideline-directed medical therapy (GDMT). We sought to determine whether the responsiveness of the autonomic nervous system to ART, as reflected in HR response to vagus stimulation during the VNS duty cycle, is maintained after long-term chronic VNS administration.

Methods

Fifteen patients with HFrEF and implanted with a VNS systems in the ANTHEM-HF study were evaluated after 4.7 ± 0.3 years (range: 4.0–5.0 years) of chronic ART. ECG electrodes were placed on each patient’s wrists, and ECG rhythm strips were recorded. Instantaneous HR time series was computed at each patient’s chronically programmed VNS intensity and during progressively increasing VNS intensity. HR during active stimulation (on-time) was compared to HR just prior to initiation of each stimulation cycle (off-time).

Results

Persistent autonomic engagement was observed in a majority of patients (11 of 15, 73%) after chronic ART for four or more years. The average magnitude of HR reduction during ART on-time in all patients was 2.4 ± 3.2 bpm at the chronically programmed VNS pulse parameter settings.

Conclusion

Autonomic responsiveness to VNS persists in patients with HFrEF who received chronic ART for up to 5 years as a supplement to GDMT. This suggests that the effects of ART on autonomic engagement and cardiac control remain durable over time.

Clinical Trial Registration

[ClinicalTrials.gov], identifier [#NCT01823887, CTRI registration #CTRI/2012/05/002681].
The Bovine Hepatic Cell Line BFH12 as a Possible Model for Hepatosteatosis in Dairy Cows
Authors: Reichelt Kristin , Niebisch Anna M. , Kacza Johannes , Schoeniger Axel , Fuhrmann Herbert
Published: March 2022

Hepatosteatosis is a common metabolic disorder of dairy cows, especially during early lactation. Currently, there are a few models of bovine hepatic steatosis available, including primary hepatocytes, liver slices, and animal models. Studies that elucidate the influence of single fatty acids on lipid classes, fatty acid pattern, gene expression, and phenotypic changes are still limited. Hence, we investigated the suitability of the fetal bovine hepatocyte-derived cell line BFH12 as a model for hepatosteatosis. To create a steatotic environment, we treated BFH12 with stearic acid, palmitic acid, or oleic acid in non-toxic doses. Thin-layer chromatography and gas chromatography were used to analyze lipid classes and fatty acid pattern, and qPCR was used to quantify gene expression of relevant target genes. Lipid droplets were visualized with confocal laser scanning microscopy and evaluated for number and size. Treatment with oleic acid increased triglycerides, as well as lipid droplet count per cell and upregulated carnitine palmitoyl transferase 1, which correlates with findings of in vivo models. Oleic acid was largely incorporated into triglycerides, phospholipids, and non-esterified fatty acids. Stearic acid was found mainly in non-esterified fatty acids and triglycerides, whereas palmitic acid was mainly desaturated to palmitoleic acid. All three fatty acids downregulated stearyl-CoA-desaturase 1. In conclusion, BFH12 can acquire a steatotic phenotype by incorporating and accumulating fatty acids. Oleic acid is particularly suitable to produce hepatosteatosis. Therefore, BFH12 may be a useful in vitro model to study bovine hepatosteatosis and its underlying molecular mechanisms.