bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of N-Heterocycles and Linear Adducts from Allyl-Containing Substrates and Sulfonamides
Authors: Ganin Anton S. , Sobyanina Mariya M. , Moskalik Mikhail Yu.
Published: February 2025

The review describes the oxidative addition of sulfonamides to allylic derivatives. The direction of
the sulfonamidation reaction depends on various factors, such as the type of allylic substrate, solvent, oxidant,
and the reactivity of the sulfonamide. Intramolecular cyclization of allyl sulfonamides is a simple method for
obtaining nitrogen-containing heterocyclic compounds with diverse structures. Reactions between O-allylic
substrates and sulfonamides in the presence of oxidizing agents can produce cyclic or linear amino ethers,
which are valuable for the synthesis of heterocyclic biologically active compounds. N-allylic substances are
excellent starting materials for the synthesis of N-heterocyclic compounds and linear products with two or three
amino groups, providing ample opportunities for further functionalization. When allylsilanes are exposed to
oxidizing conditions, they undergo desilylation, allowing for the introduction of an allylic group into reactions
with sulfonamides, resulting in products free from Si-heteroatoms, based on a C3-allylic scaffold and sulfonamide
nitrogen. The choice of reaction medium and oxidizing agent can significantly affect the course of the
reaction, leading to the formation of different products. The main products include aziridines, pyrrolidines, piperazines,
lactams, oxazolidines, amino ethers, amidines (imidazoline precursors), and products of aminohalogenetation.
This review provides a comparative analysis of the reactivity of sulfonamides in oxidative addition
reactions and considers the advantages and disadvantages of synthetic methods.
Genistein as a Chemo-modulatory Agent: Exploring its Potential in
Chemosensitization and Combinatorial Therapeutic Strategies for Cancer
Treatment
Authors: Sailo Bethsebie Lalduhsaki , Vishwa Ravichandran , Girisa Sosmitha , Aswani Babu Santha , Abbas Mohamed , Alqahtani Mohammed S , Almubarak Hassan Ali , Hegde Mangala , Kunnumakkara Ajaikumar B
Published: February 2025

Genistein (GEN), a phytoestrogen primarily sourced from soy plants, is recognized for
its anticancer properties attributed to its roles as a tyrosine kinase inhibitor, an estrogen receptor
agonist, and its influence on various cancer hallmarks by modulating diverse signaling pathways.
Recent research has highlighted the considerable potential of GEN in combating drug resistance in
cancer cells. This attribute of GEN has been demonstrated by its capacity to modulate tyrosine
kinases such as HER2, HER3, and EGFR which are implicated in tumorigenesis, as well as prosurvival
signaling pathways including NF-κB and Akt/mTOR. Moreover, GEN impacts drug accumulation,
AR-driven transcriptional regulation, ER signaling, and various genes that are involved
in autophagy, pro/anti-apoptosis, DNA methylation, and histone acetylation. Further, GEN
demonstrated efficacy in combinatorial therapy with various standard anticancer agents like 5-FU,
cetuximab, cisplatin, clofarabine, doxorubicin, tamoxifen, TRAIL, trastuzumab, and other agents
with anticancer activities such as capsaicin, curcumin, daidzein, lycopene, resveratrol, sulforaphane,
etc., across a spectrum of cancers including the cancers of bone, brain, breast, cervix,
colorectal, endometrium, esophagus, head and neck, leukemia, liver, lung, ovary, pancreas and
stomach. Thus, further clinical validation of these potential combinations involving GEN is warranted
to confirm the preclinical findings.
Impact of Pre-Lockdown Hyper-Energy on Mood and Rhythm Dysregulation in Older Adults During the COVID-19 Pandemic
Authors: Primavera Diego , Kalcev Goce , Bert Fabrizio , Cantone Elisa , Perra Alessandra , Tusconi Massimo , Pinna Samantha , Orrù Germano , Scano Alessandra , Tramontano Enzo , Barbov Ivan , Nonnis Marcello , Nardi Antonio Egidio , Cossu Giulia , Sancassiani Federica , Carta Mauro Giovanni
Published: February 2025

Objective

The aim of this work is to verify whether a cohort of elderly people with hyper-energy tended to increase depressive symptoms and misaligned social and personal rhythms during the lockdown compared to a cohort of older adults without hyper-energy one year before the lockdown.

Methods

The two cohorts were evaluated in April 2019 (T0) and in April 2020 (T1). Hyper-energy, cognitive performance, depressive symptoms, and social and personal rhythms were evaluated at T0 and T1.

Results

In the measure of the Brief Social Rhythm Scale (BSRS) score, the differences between groups in the two observation times reach statistical significance. The sub-group with previous hyper-energy at T0 but no longer having hyper-energy at T1 increases the score by more than 5 points (a higher score indicates greater rhythm dysregulation, thus having a worse regulation of rhythms at T1), while in those individuals who didn’t have hyper-energy, the score remains substantially unchanged (+0.06). However, if the increase in the score from T0 and T1 is measured, both groups with hyper-energy at T0 presented a greater mean increase compared to people who did not have hyper-energy at T1. In the total of the eleven elderly people with hyper-energy at T0, the mean increase in BSRS score was 1.05±1.19 versus 0.06±0.98 (F=9.407, P=0.003), and in people who no longer had hyper-energy at T1, it was 1.05±1.19 versus 5.50±3.83 (F=105.0, P<0.0001). In people with hyper-energy at T0, the mean increase in the Patient Health Questionnaire-9 (PHQ-9) score was 0.72±0.75 versus 0.01±0.28 (F=37.153, P<0.0001). The gain was even higher in people who no longer had hyper-energy at T1, 1.38±1.03 vs. 0.01±0.28 (F=87.386, P<0.0001). An inverse linear correlation was found between energy perception (measured as the score of Item 10 of SF-12) and the score of PHQ-9 measuring depressive symptoms both at T0 and, more strongly, at T1, as well as with the BSRS scores, but only at T1.

Conclusion

The study, despite the limitations of a small sample, seems to confirm a greater vulnerability to the lockdown situation in people with hyperactivity, even in the absence of psychopathology (i.e., part of the bipolar spectrum).
Research Progress on Small Molecule Inhibitors of MDM2-p53 Protein-protein Interaction
Authors: Hu Meiyao , Xu Chang , Xu Mingxin , He Siyu , Liu Dandan
Published: February 2025

The p53 protein, renowned as the "anti-cancer protein," plays a critical role in regulating the cell cycle,
inducing apoptosis, and repairing DNA. Its dysregulation often leads to genomic instability and tumorigenesis.
MDM2, a key negative feedback regulator of p53, inhibits both the transcriptional activity and stability of p53,
thereby suppressing the anti-cancer effect of p53. With the resolution of the co-crystal structure of the MDM2-
p53 complex, using small molecule inhibitors to block their interaction has emerged as a promising cancer treatment
strategy. These inhibitors can remove the negative regulation of MDM2 on p53 and allow p53 to function as
a "tumor suppressor protein". Over recent decades, researchers have designed and synthesized small-molecule
inhibitors with diverse structures, showing notable anti-cancer efficacy in preclinical studies. Although several
inhibitors have entered clinical trials, none have yet been approved. This review comprehensively summarizes the
recent advancements in small-molecule inhibitors of MDM2-p53 protein-protein interaction (PPI) according to
different types of structural scaffolds, primarily focusing on imidazolines, spirooxindoles, pyrrolidines, pyrrolones,
piperidines, piperidines, purine carboxylic acid derivatives, isoquinolines, pyrazolopyrolidinone analogs,
imidazothiazoles, quinolones, and spiroindolines. Additionally, this review focuses on their design, synthesis, and
biological evaluation and highlights the structure-activity relationships and ongoing efforts. Despite the progress
made, challenges remain. Researchers are exploring strategies to overcome these obstacles in promoting the research
on drugs targeting MDM2-p53 PPI with stronger affinity, higher permeability, and a more significant
effect.
Oral Microbiome Modulates Tumor Micro-Environment Potentiating Oral Cancer Progression from Benign Stages- A Scoping Review
Authors: Goswami Gargi Roy , Patil Rujuta , Ghosh Somedatta , Kaur Geetpriya , Banerjee Abhijit G.
Published: February 2025

Background:

Oral Squamous Cell Carcinomas (OSCC) are one of the common causes
of death globally. Several etiological factors cause OSCC, including alcohol, tobacco use, poor
oral hygiene, Human Papilloma Virus (HPV) infections, Yeast (Candida spp.) infections, etc.
Oral microbial dysbiosis and inflammatory conditions like periodontitis have also been implicated
recently. The host-microbiome interactions may further alter the homeostasis of the oral Tumor
Microenvironment (TME). In this review, we aim to determine the role of resident microbiota in
oral cancer progression and decipher how they interact with the TME. The article also discusses
potential biomarkers and therapeutic targets to enhance the management of OSCC.

Methods:

PubMed, Medline, and Google Scholar were used as biomedical literature databases.
The following keywords were looked up for academic literature using Boolean operators. Initially,
a total of 273 articles were found as a result of the literature search.

Results:

Finally, 142 articles that met the exclusion and inclusion criteria were chosen for literature
review,as depicted in the PRISMA flowchart (Fig. 1).

Discussion:

Multiple oral bacterial species are linked to OSCC. Modulation immunotherapies
that target the TME and reverse oral microbiota dysbiosis have been proposed in recent investigations.
Changes in the oral microbiota have an impact on the oral microenvironment, leading to inflammatory
cell infiltration, cytokine release, and chronic inflammation. All the data support an
immunosuppressive TME. Antifungal and antibacterial medications are currently advised for the
treatment.

Conclusion:

We conclude that the utilization of microbial biomarkers and generated products as
potential anticancer targets could be one of the methods for mitigating oral cancer. Tumor immunotherapies
are the newest method for treating cancer patients. However, there are still a lot of
drawbacks. We attempted to outline the possible approaches to potential immunotherapies.
Sanskrit Medical Scholasticism III: Jajjaṭa’s Nirantarapadavyākhyā and Other Commentaries on the Carakasaṃhitā, Cikitsāsthāna 2.3
Authors: Zysk Kenneth G. , Yamashita Tsutomu
Published: February 2025

This paper is a continuation of “Sanskrit Medical Scholasticism II — Jajjaṭa’s Nirantarapadavyākhyā and Other Commentaries on the Carakasaṃhitā, Cikitsāsthāna 2.2 —” and offers a translation and analysis of the Caraka­saṃhitā, Cikitsāsthāna Chapter 2, Quarter 3 (CaCi 2.3) along with the four commentaries.
Explorando la diversidad agrícola de Colombia: Catálogo de la Colección Colombiana de Germoplasma de Mora (Rubus spp.)
Authors: Rosero Alpala María Gladis , Henao Rojas Juan Camilo , Ortiz Muñoz Carolina , Velásquez Arroyo Carlos Enrique , López Hernández Luis Felipe , Ramírez Gil Joaquín Guillermo , Cañar Serna Dubert Yamil
Published: February 2025

El catálogo de la Colección Colombiana de Germoplasma (ccg) de mora es una invaluable fuente de información que presenta la variabilidad genética de las accesiones de este frutal, provenientes de diversas regiones de Colombia y el mundo, cada una de ellas con características únicas y potencialidades extraordinarias, por lo cual constituye un recurso genético imprescindible para la investigación científica y el desarrollo agrícola.
Esta obra recoge información detallada sobre los especímenes de mora disponibles en el país, datos relevantes para su cultivo y aprovechamiento, incluyendo las diferentes accesiones y sus especies relacionadas, así como su potencial adaptabilidad a distintos entornos. Contempla moras de variados tamaños, colores y sabores que pueden ofrecer otras características, como resistencia y adaptación a climas específicos.
Nuestra colección ofrece opciones que pueden satisfacer las necesidades de los agricultores, investigadores y lectores interesados. Cada accesión de mora cuenta con información técnica completa y precisa, desde descripciones detalladas de su apariencia física hasta características morfométricas y calidad de los frutos, entre otros aspectos relevantes. Estos datos son de gran valor para quienes deseen seleccionar variedades en cultivos existentes o para nuevas áreas de producción. Asimismo, resultan claves para la investigación y el desarrollo de variedades promisorias en el cultivo de mora.
En síntesis, el catálogo de la CCG de mora es una herramienta fundamental para aquellos que deseen explorar y aprovechar la rica variabilidad genética de la que dispone la colección. De esta manera, se promueve la conservación, el estudio y la utilización sostenible de este valioso recurso biológico, y se asegura así la promoción continua del material genético para el mejoramiento de los cultivos y la innovación en la industria de la mora. Los lectores pueden explorar el catálogo y descubrir las increíbles oportunidades que ofrece la colección.
Evaluating smartphone sensor-based assessments of physical function with older adults: A four-week feasibility and usability study (Preprint)
Authors: Kempton Christian , Ryan Kate , Clohessy Sophie , Grinbergs Peter , Elliott Mark T.
Published: February 2025

BACKGROUND

Digital platforms and smartphone apps have the potential to help patients with musculoskeletal conditions receive targeted interventions and physiotherapy support within their own home. Currently, other than relying on patients completing questionnaires, there is no direct way to observe their engagement with exercises or track any changes in their physical function, such as balance. We have developed a method that uses the inertial sensors available in all smartphones to track and measure sit-to-stand and single leg balance, used by physiotherapists to assess physical function in patients with musculoskeletal conditions. As musculoskeletal conditions are much more prevalent in older age, it is important to investigate whether these technologies can be used by this demographic, who generally have lower digital literacy than younger adults.

OBJECTIVE

In this study, we trialled the technology in a sample of older adults, aged 65 years or over. The objective of the study was to use a mixed-methods approach to investigate the feasibility and perceived usability of completing functional exercises whilst recording the activity using smartphone inertial sensors within this age group.

METHODS

Participants (n=21) were recruited from a diverse range of community settings, including supported living accommodation, religious centres and community centres. Following an in-person onboarding session, participants completed a four-week trial, recording unsupervised sit-to-stand and single leg balance activities at least once a week, using their smartphone. At the end of the trial, we gathered feedback on usability using telephone interviews and the System Usability Score (SUS). We analysed data quality according to the proportion of uploaded datasets that were successfully analysed using the developed algorithms. Finally, we measured adherence by analysing the number of exercises completed each week.

RESULTS

Inductive content analysis was used to identify and analyse five top-level categories: App, Device, Exercise, Time and Personal Perceptions. Within the top-level categories, the recorded notes and quotations were further classified into sub-concepts. Mean SUS score was 81.217.5. The proportion of valid data uploads was 63.8% for single leg balance and 93.5% for sit-to-stand measures. Adherence was high with no significant deviations in terms of mean number of sessions completed, or duration between sessions

CONCLUSIONS

Overall, smartphone-based monitoring of functional activities can facilitate unsupervised, remote assessments, thus reducing burden on physiotherapy services and increase ability to monitor progress objectively. However, activities should be limited to simple, stable activities such as sit-to-stand, whilst feedback is essential to motivate and inform users of their progress and adherence to the activities.
Exploring User Preferences in Haptic-Driven Serious Card Games for Older Adults Cognitive Rehabilitation (Preprint)
Authors:   INTERAKSI
Published: February 2025

BACKGROUND

Cognitive rehabilitation (CR) is an essential intervention for older adults with cognitive impairment, aiming to restore or compensate for cognitive decline. Traditional methods, such as paper-and-pencil exercises, often lack ecological validity and engagement. Serious games have emerged as a promising alternative, especially those incorporating haptic feedback technology. Haptic feedback enhances user interaction by simulating the sense of touch, potentially improving cognitive performance while reducing reliance on visual information. However, there is limited research on the preferences for haptic feedback in serious card games designed specifically for cognitive rehabilitation in older adults.

OBJECTIVE

The study aims to investigate older adults' preferences for haptic feedback in mobile serious card games and to assess its potential for enhancing cognitive function.

METHODS

The present study recruited a total of 250 participants from Dangtu County, Anhui Province, China, with an average age of 70 years. A descriptive survey was conducted among older adults, and structured questionnaires were distributed and data collected via the Wenjuanxing mobile application. Reliability and validity analyses were performed using the Statistical Package for the Social Sciences (SPSS) software. The questionnaire investigated older adults' basic understanding of card games and serious games, the integration of card games with mobile devices, the potential impact of combining card games with haptic feedback technology, as well as suggestions and opinions.

RESULTS

The results showed that 63.2% of the older adults liked the mild haptic feedback mode, and 78.4% of the participants believed that combining haptic feedback technology with mobile card games would help improve cognitive abilities. The study found that 73.6% of the older adults believed that this technology could reduce their reliance on visual information. This confirms that the combination of serious card games and haptic feedback can alleviate sensory impairments in the older adults. Qualitative analysis revealed the potential of haptic feedback to reduce visual fatigue and provide an engaging cognitive training experience.

CONCLUSIONS

Older adults have shown great interest in incorporating haptic feedback into mobile serious card games, believing that this could enhance their cognitive abilities while reducing their reliance on visual information. However, limitations include limited sample size. Longitudinal studies are recommended to evaluate the long-term effects of mobile serious card games with haptic feedback on cognitive abilities. Such investigations could provide valuable insights for game developers, rehabilitation institutions, and the development of cognitive training tools for older adults.
Formulation Modification of Yoniprakshalan Kwatha as an Intimate Wash (YOSHA) and their Comparative Quality Control Assessment and in Vitro Evaluation of Antimicrobial Activity: A Study Protocol (Preprint)
Authors: Jadhav Prachi , Rathi Bharat Jagdishji
Published: February 2025

BACKGROUND

Most women at some point in their life experience vaginal itching, which is a prevalent and often harmless ailment. Numerous diseases, long-term medications like OC pills, STDs, hormonal fluctuations throughout time, and unhygienic vaginal environments can all contribute to these symptoms. If left untreated, this condition can lead to severe difficulties or even death. Even with these effective medicines, they frequently have extremely unpleasant side effects that can worsen the underlying illness.

OBJECTIVE

i) To prepare Yoniprakshalan kwatha as per the reference of Yogratnakar and its modified dosage form Yosha.
ii) To assess the quality control parameters of Yonoprakshalan kwatha and Yosha.
iii) To investigate the antimicrobial effects of Yonoprakshalan kwatha and Yosha.
iv) To compare the antimicrobial activity of Yosha and yoniprakshalan kwatha.

METHODS

Raw medication will be sourced from institutional Rasashala and undergo primary authentication and verification by taxonomists. After it has been prepared, the medicine will undergo quality control and antimicrobial profile testing.

RESULTS

The research will evaluate yoniprakshalan kwatha and yoniwash (YOSHA) In-vitro assessment will be tested for antimicrobial activity using one-way ANOVA.

CONCLUSIONS

Pharmaceutical and analytical study of yoniprakshalan kwatha and modified form as intimate wash will provide the standard parameters.

CLINICALTRIAL

MGACHRC [IEC/Jun -2024/854]
Analisis Program Pengawasan Proyek Strategis Nasional oleh Badan Pengawasan Keuangan dan Pembangunan
Authors: Akhmadi Adhitya
Published: February 2025

Audit internal saat ini mengalami pergeseran peran dari yang semula berfokus pada pengendalian dan pelestarian nilai (value preservation) menjadi penciptaan nilai (value creation). Badan Pengawasan Keuangan dan Pembangunan (BPKP) selaku auditor internal pemerintah Indonesia memiliki tugas dan fungsi untuk melakukan pengawasan terhadap program pemerintah yang bersifat strategis dan bertujuan untuk memeratakan pembangunan nasional dan meningkatkan kesejahteraan masyarakat yang lebih dikenal sebagai Proyek Strategis Nasional (PSN).Penelitian ini bertujuan untuk mengeksplorasi peran BPKP dalam pelaksanaan PSN. Selain itu, penelitian ini juga bertujuan untuk mengetahui faktor-faktor yang berkontribusi dalam pemenuhan peran BPKP tersebut. Landasan teori yang digunakan dalam penelitian ini adalah konsep peran audit internal yang dikemukakan oleh Eulerich dan Lenz (2020) yang didasarkan pada model tiga lini (three lines model) dari The Institute of Internal Auditor (IIA). Penelitian ini menggunakan pendekatan kualitatif dengan wawancara mendalam (in-depth interview) dan reviu dokumen sebagai metode pengumpulan data. Data wawancara dan reviu dokumen dianalisis dengan menggunakan model analisis data Creswell.Hasil penelitian ini menunjukkan bahwa BPKP berperan sebagai partner tata kelola (governance partner) dan penasihat tepercaya (trusted advisor) dalam pengawasan PSN. Peran sebagai partner tata kelola dijalankan oleh BPKP dengan melaksanakan reviu tata kelola dan audit yang bersifat wajib (mandatory). Peran sebagai penasihat tepercaya diwujudkan dengan keterlibatan BPKP dalam kegiatan debottlenecking (pengurai hambatan) atas permasalahan yang terjadi dalam pelaksanaan PSN. Di lain pihak, pengawasan yang dilakukan BPKP belum menjadi penggerak nilai (value driver) bagi manajemen PSN. Dukungan pemangku kepentingan dan kapasitas sumber daya manusia menjadi faktor yang berkontribusi terhadap pengawasan BPKP pada PSN.
Evaluasi Waste Management Dengan Lean Thinking pada Siklus Produksi : Studi Kasus pada Mixed Ownership Company
Authors: Amri Muhammad Aditya , Herdhayinta Heyvon
Published: February 2025

Tujuan – Tujuan penelitian ini adalah untuk mengevaluasi waste management dengan lean thinking bertujuan untuk melihat dan memperbaiki berbagai peluang terjadinya pemborosan dan sarana perbaikan berkelanjutan serta meningkatkan efisiensi produksi di PT. XYZMetode Penelitian – penelitian ini menggunakan data kualitatif dengan bentuk data triangulasi yang diperoleh melalui wawancara, observasi, dan analisis dokumen dengan tujuan memperoleh kekayaan data untuk pengambilan keputusanTemuan – terdapat pemborosan yang ditemukan pada produksi gula di PT. XYZ ini, hal ini dapat disebabkan oleh kesalahan management, kesalahan operasioanal maupun faktor alam yang tidak dapat dihindari. PT. XYZ merupakan agroindustri yang dimiliki secara mixed ownership, sebagai agroindustri sangat bergantung pada kualitas hasil perkebun yang sensitif terhadap perubahan alam, pasokan tebu diperoleh melalui kebun PT. XYZ atau membeli bahan mentah dari petani. selanjutnya pada proses pengolahannya diperlukan parameter produksi untuk mendapatkan hasil gula yang maksimal. Namun karena tidak bisa dicapainya proses produksi yang optimal karena terjadinya kerusakan alat, kondisi operasi yang tidak bisa terpenuhi, ketidak akuratannya penimbangan maupun kelalaian operator menyebabkan terjadinya pemborosan. Pemborosan yang telah teridentifikasi dilakukan penanganan paling efektif sebagai tindak pencegahan agar tidak terjadi pemborosan biaya secara berkelanjutan.Orisinalitas - Objek penelitian kali ini berada di Indonesia yang memiliki status mixed ownership yang merupakan perkembangan dari status kepemilikan state owned enterprise, sehingga diharapkan dapat menjalankan proses evaluasi, identifikasi pada waste management dari aktivitas siklus produksi yang telah berjalan selama ini. Penelitian ini menggunakan kerangka yang disusun oleh Klein (2020) untuk dapat mengevaluasi waste management pada siklus produksi.
Exploration and Practice of the Construction of Art Design Training Base under the Background of Digital Technology
Authors: Yu Weizhong
Published: February 2025

With the continuous development of digital technologies such as artificial intelligence, big data, cloud computing, interaction design, and 5G, digital technology has brought infinite creative possibilities to art and design. The article focuses on the construction of the art and design training base at Zhejiang Vocational and Technical College of Commerce, which is supported by the central government. Starting from the construction concept, content, teaching mode, curriculum reform, teaching team, and management of the training base, the article conducts in-depth research and proposes innovative ideas, which play a demonstrative role in the construction of art and design training bases and the cultivation of art and design professionals under the background of digital technology.
A Study on Meanings of English Polysemous Nouns from the Perspective of Cognitive Domain
Authors: Xiang Jianglin , Chen Chaoqin , Huang Wanwu
Published: February 2025

This study presents a systematic investigation of English polysemous nouns from the perspective of cognitive domains, exploring how different cognitive domains contribute to the construction and extension of noun meanings. The research identifies and analyzes two fundamental types of cognitive domains: the Cognitive Domain for Entity and the Cognitive Domain for Event. The former is further divided into macro-cognitive and micro-cognitive domains, while the latter manifests through verb-noun and preposition-noun structures.Through detailed analysis of authentic language examples, this study reveals that the Macro Cognitive Domain exhibits conventional characteristics of entities and establishes fixed noun meanings, while the Micro Cognitive Domain reveals entity-specific qualities that become salient in particular contexts. The research also demonstrates how nouns can extend their meanings from entity reference to event reference through qualia structure and prepositional constructions.The findings suggest that noun polysemy is systematically motivated by cognitive mechanisms and contextual factors, rather than being arbitrary. This study not only advances theoretical understanding of polysemy but also provides practical implications for language teaching and learning. The cognitive domain framework offers valuable insights into how words acquire and maintain multiple related meanings within systematic cognitive structures.
The Role of Green Product Trust in Mediating the Influence of Eco-Branding and Brand Uniqueness on Green Purchase Intention in KALIMBO Bag Products
Authors: Erliani Aida , Rinuastuti Baiq Handayani
Published: February 2025

This study aims to determine the role of green product trust in mediating the influence of eco-branding and brand uniqueness on green purchase intention. This study uses a quantitative approach with 150 respondents. The analysis tool uses SEM-PLS with the SmartPLS 4.0 application. The results of this study show that eco-branding has an insignificant direct influence on green purchase intention but has a significant influence when mediated by green product trust. Meanwhile, brand uniqueness significantly influences green purchase intention both directly and when mediated by green product trust. These findings prove the importance of creating trust in green products.
Blåleire og brunleire fra Enebakk leireuttak
Authors: Sigrid Espelien
Published: February 2025

Denne leira og beholderen representerer blåleire som en del av et industrilandskap i prosjektet.

keywords: blåleire, kunstnerisk forskning, clay, blueclay, artistic resaerch, teglindustri, enebakk leireuttak, blåleire og brunleire fra enebakk leireuttak, leca fabrikken, LECA, ravinelandskap, brunleire, ekstraktiv industri
Samtale med tidligere fabrikksjef på Bratsberg teglverk John Arne Rinde 04.10.2022
Authors: Sigrid Espelien
Published: February 2025

Samtale med tidligere fabrikksjef på Bratsberg teglverk John Arne Rinde 04.10.2022. Bø i Telemark.

keywords: blåleire, murstein, tegl, kunstnerisk forskning, clay, brick, blueclay, artistic resaerch, brick industry, teglindustri, teglhistorie, brick history, Bratsberg teglverk, kroppslig kunnskap, situert kunnskap
Psychoanalysis for the Virtual Reality
Authors: Tolga Theo Yalur
Published: February 2025

Psychoanalysis is always targeted in theory with armchair theorizing. A very distorted sense of the phenomena from the armchair introspection and speculation and almost-limited theorizing in behavioral psychologies and even in psychoanalysis invests itself in human experiential stances instead of objective observation. To construct a theory based upon these phenomena, however, there’s too much data. What psychoanalysts do is to demonstrate to the people, through self-experiments, how simple it is to misunderstand what is actually in their consciousness and in their first-person data. What’s remarkable about consciousness is that it is not continuous. There are countless voids in the information of consciousness, some of which work in the psychoanalytic experience of diagnosing symptoms in first- person data, the beliefs about the experiences to which individuals have exclusive access. Its discontinuity, the voids and the holes are limited to these beliefs. For the fact that language works discursively, humans may renounce their privileged access to these experiences and shift their focus from what they believe to what actually is the case. In the end, there will be a scientific narrative in which the conscious self will not be a character. A living body, a living brain, and everything else is all that exists. The first-person narrative would be extracted from that third-person account. The conscious self never exists in any other sense. Thinking that it would exist is the illusion.

keywords: psychoanalysis, virtual reality, Discourse
Global Public Health: Sustainability Development Challenges for Mental Health
Authors: Illingworth Paul
Published: February 2025

This paper is based on a Keynote address the author gave at the 9
th International Global Public Health Conference, in
Manila, Philippines July 2024. The paper explores how mental health care
has been, and continues to be viewed through dominant models. And
suggests that by taking an intersectional view of mental health, it
demonstrates that mental health has not been given the same degree of
importance and has not had fair and equitable attention in policy,
strategies and resources. The author offers solutions which emphasises a
seismic shift is needed by the UN, WHO and Governments to move from a
dominant western medical model.
Spontaneous resolution of pemphigus vulgaris-induced desquamative gingivitis. A case report and brief review of the literature
Authors:   Department of Stomatology, Division of Stomatology Clinic, School of Dentistry, University of São Paulo, São Paulo, Brazil, Migliari Dante
Published: February 2025

Desquamative gingivitis (DG) is important in oral medicine because it is not a pathologic entity itself; rather, it is a clinical manifestation of dermatological disease most frequently associated with chronic inflammatory (e.g., oral lichen planus) and autoimmune diseases, mainly pemphigus vulgaris and mucous membrane pemphigoid, and several cases have been reported till date. Herein, we describe a case of pemphigus vulgaris-associated DG with unusual clinical behavior, in which the gingival lesions spontaneously resolved after consistently showing no response to various treatments. Additionally, a brief review of the literature focusing on the management of DG is provided.
Regulation of Type 1 Diabetes via Brown Adipocyte-Secreted Proteins and the Novel Glucagon Regulator Nidogen-2.
Authors: Lee Jeongmin , Ustione Alessandro , M Wilkerson Emily , Balakrishnan Rekha , C. Thurmond Debbie , Goldfarb Dennis , W. Piston David
Published: February 2025

Current treatments for type 1 diabetes (T1D) focus on insulin replacement. We demonstrate the therapeutic potential of a secreted protein fraction from embryonic brown adipose tissue (BAT) that mediates insulin receptor-dependent recovery of euglycemia in a T1D model, nonobese diabetic (NOD) mice, by suppressing glucagon secretion. This fraction promotes white adipocyte differentiation and browning, maintains healthy BAT, and enhances glucose uptake in adipose tissue, skeletal muscle, and liver. We identify nidogen-2 as a critical BAT-secreted protein that reverses hyperglycemia in NOD mice, inhibits glucagon secretion from pancreatic α-cells, and mimics other actions of the entire secreted fraction. Secretions from a BAT cell line with siRNA knockdown of nidogen-2 fail to inhibit glucagon secretion and restore euglycemia. These findings demonstrate that BAT-secreted peptides represent a novel therapeutic approach to diabetes management. Furthermore, our research reveals a novel signaling role for nidogen-2, beyond its traditional classification as an extracellular matrix protein.
Stunting Service Management Model in the South-Central Timor Region, East Nusa Tenggara, Indonesia
Authors: F Salesman , EM Roslin Sormin , M Neolaka , H Toda
Published: February 2025

South Central Timor is one of the regions with a high prevalence of stunting in Indonesia. The programs and policies that have
been carried out have been unable to reduce these health problems effectively. This study resulted in an innovative service
model based on intelligent Governance. The design of this study is a sequential explanatory model using the mixed method. The
research subjects were 226 respondents and 527 midwives in 27 South Central Timor region health centres. The results of
the analysis found that there are factors that inhibit the management of stunting management services in community health
centres in South Central Timor Regency, including (a) tractability of the stunting problems, (b) diversity of group behaviour, (c)
clarity of policy content, (d) accuracy of allocation of funding sources, (e) socioeconomic conditions of the community and the
level of technological advancement, (f) official support for stunting prevention policies. The analysis results have an adjusted
R2 (Adjusted R Square) value of 0.436. Service implementation needs to be carried out collaboratively and participatory, especially related to data, policies, budgets, coordination, socialization, and implementation.
Digital Safety Monitoring System for Auto Repair Company
Authors: Egelsky V. V. , Nikolaev N. N. , Egelskaya E. V. , Panfilova E. A.
Published: February 2025

Introduction. The scientific literature discusses the potential of artificial intelligence (AI) for ensuring industrial safety. Risk control methods are considered and recommendations for incident prevention are given. The relationship between the competencies of lifting crane operators and the probability of accidents has been studied. Examples of using neural networks for determining the reliability of removable lifting devices are presented. Remote monitoring of operational safety is described. However, the use of AI to manage risks in a car repair station has not been sufficiently studied. This research aims to address this gap. The aim of this work is to demonstrate the potential of neural networks in creating a safety monitoring system for an automobile repair facility.

Materials and Methods. The design materials of the service station at the equipment repair and maintenance center served as basic information. This enterprise was created by specialists of the Department of Operation of Transport Systems and Logistics at the Don State Technical University (DSTU). Risks were classified according to GOST ISO 12 100 and GOST R 58 771. Neural networks were trained using open-source libraries for the Python programming language. The digital monitoring system model with visualization was implemented using the AnyLogic simulation system.

Results. The authors of this work trained 20 neural networks and selected five with the lowest error function values (from 74% to 78%). Out of five networks that worked most correctly, one was chosen that predicted the output parameter more accurately — 74%. The neural network with the best performance was a multilayer perceptron with 30 neurons in the input layer, 15 in the hidden layer, and 3 in the output layer. It was used to create a digital twin that warned in real time about potentially dangerous events: the movement of a car, a crane, and the opening of an inspection pit. Additionally, it identified workers without personal protective equipment or access to the work area.

Discussion and Conclusion. The use of a digital safety monitoring system model will make it possible to identify high-risk work areas in advance, and reduce accidents and industrial injuries. The introduction of this model in auto repair facilities involves the installation of sensors and warning systems. In the future, we plan to explore the possibility of integrating algorithms with the risk monitoring system to help personnel repair specific types of machines.
Undergraduate students future career intention in the hotel industry: The impact of implementing the certified internship program
Authors: Ferdian Feri , Yulastri Asmar , Zahari Mohd Salehuddin Mohd , Suyuthie Hijriyantomi , Pasaribu Pasaribu
Published: February 2025

This scholarly investigation examines the effect of hotel hallmarks of the hotel industry, service quality of internship and internship satisfaction on undergraduate hotel management students' future career intentions in the hotel industry. A quantitative approach through a cross-sectional study with a self-reported survey questionnaire was undertaken. The sample and the unit of analysis is among hotel management students from Universitas Negeri Padang, West Sumatera, Indonesia who had undergone internships program. The study employs Partial-least Square-Structural Equation Modelling (PLS-SEM) in response to the hypotheses. The results clearly demonstrated that hallmarks of the hotel industry (less pleasant work environments, heavy job responsibilities, slow career development opportunities, and less recognition of work achievement) did not possess negative impact on hospitality interns’ students future career intentions in the hotel industry. Hotel internship service quality and internship satisfaction strongly influence hospitality interns’ students future career intentions in the hotel industry. The findings manifestly provide valuable insights and far-reaching consequences for students, hospitality institutions, industry stakeholders and policymakers.
Optimizing control structure and branching learning with flipbook-based e-module for software engineering students
Authors: Febrianti Ria , Tuwoso Tuwoso , Hidayat Wahyu Nur , Wardani Yurike
Published: February 2025

This research highlights the significance of developing innovative learning media to enhance effective learning for class X Software Engineering (RPL) students at SMK Negeri 4 Malang. The study addresses the need to improve student engagement and deepen understanding of concepts, particularly in Control Structure and Branching material. The primary objective is to create an interactive and innovative Flipbook-based e-module as practicum media to support the learning process. Using the Research and Development (R&D) method with the ADDIE model (Analyze, Design, Develop, Implement, Evaluate), this research employs a systematic and structured approach in developing learning products. The Flipbook-based e-module achieved a feasibility score of 90% from material experts and 97.5% from media experts, indicating its high validity and feasibility. During the trial phase, the e-module obtained feasibility score of 89% from a small group and 90% from a large group, resulting in an average feasibility score of 89.5%. These findings demonstrate that the Flipbook-based e-module is highly suitable for implementation in the Vocational Basics subject for class X RPL students at SMK Negeri 4 Malang. Additionally, the small group test showed a student learning motivation score of 85.4%, while the large group test yielded 87%, with an average of 86.2%. This indicates that the developed product significantly supports students’ learning motivation, proving its high validity in improving engagement and understanding. These results affirm the Flipbook-based e-module is potential as an effective learning tool for vocational education.
Impacto de los influencers políticos en la configuración de la opinión pública y la participación política en Instagram
Authors: Palacios-López Maitane , Bonete-Vizcaíno Fernando , Vázquez-Barrio Tamara
Published: February 2025

Con el asentamiento de las redes sociales como medios de comunicación de masas y la aparición y auge de los influencers, la política suma nuevos canales y fórmulas de comunicación. El objetivo general de este estudio es investigar el papel que desempeñan los influencers políticos en la configuración de la opinión pública y la participación política a través de las redes sociales, en concreto Instagram, analizando sus estrategias comunicativas, el impacto en sus audiencias y su influencia en el debate político. Con este propósito, se han identificado los perfiles de los influencers de política de relevancia en Instagram España (N=25), y se han analizado las 25 publicaciones fijas más recientes en el momento de la fecha de extracción de cada uno de esos perfiles (n=625) a través de categorías de análisis relativas al perfil del influencer, a las métricas de contenido y las métricas del prescriptor. Los resultados de esta investigación confirman que las interacciones (likes, comments, shares y saves) en las cuentas de los influencers políticos en Instagram constituyen una forma relevante de movilización política digital que puede tener repercusiones directas en la esfera participativa. El hecho de que el 5,58% de la audiencia interactúe con estos prescriptores no solo indica un nivel elevado de engagement, sino que se alinea con la hipótesis de la pasarela (Kim et al., 2017), que postula que la participación política online puede actuar como un catalizador de la participación offline.
Analysis of Tendencies and Defining Forms and Methods of Corporate Education in Russia
Authors: Dubovitskiy Roman A.
Published: February 2025

Results of research in socio economic and pedagogical segment of education in corporate education are rep-resented. Data connected with management of corporate university is provided as well as from perspective of forms and methods of education. Research on socio economic segment identifies the following: necessity of strategic planning, operation as driver of innovations, practical application of education. Pedagogical segment of research defines tendencies connected with life-long learning paradigm, self-awareness of adult education, freedom to choose programs of self-development. The research indicates that distant forms of education pre-vail and will keep the trend in the future. Classic lecture with case studies is the best form of education but it has to be methodologically adapted to distant format. The absence of adaptation lead to very poor efficiency of corporate education. The research concludes that lectures and other methods of distant learning in compliance with information and communication technologies (ICT) have to be verified in accordance with fundamental principles of pedagogy. The author provides recommendation for the use of artificial intelligence in the man-agement of educational programs in a corporate university. Further development of research in the field of methodology of corporate education in the realm of ICT has been drafted.
Possibilities of Implementing the Pedagogical Technology “Cooperative Learning” in the Process of Teaching the Academic Discipline “Foreign Language”
Authors:   Lukyanov Orel Law Institute of the Ministry of Internal Affairs of Russia, Shashkova Valentina N.
Published: February 2025

The article examines the pedagogical technology “cooperative learning” and the development of possible ways of its implementation in the teaching of the academic discipline “Foreign Language” in educational organiza-tions of the Ministry of Internal Affairs of Russia. The aim of the article is to demonstrate the advantages of us-ing the technology of “cooperative learning”, namely: solving a set of practical problems in the classroom in the academic discipline “Foreign Language”, maximizing the proximity of tasks to the conditions and requirements of professional activity, as well as creative and stimulating approaches to improving the professional foreign language communicative competence of cadets. The technology proposed for use is considered in terms of its concept, goals and content of each stage of its implementation, their sequence, as well as a variety of methods and techniques, such as situational analysis, mental mapping, fishbone technique, parallel and alternative learning. The main conditions for the successful implementation of the technology in question in the educa-tional process are the profiling of the material, practical orientation, emphasis on the communicative activities of students, the preparation of factual and linguistic supports for the communicative practice of cadets.