bluuebunny/crossref_metadata_2025 huggingface dataset:
A pécsi püspökség festészeti gyűjteménye. Művek a 16–19. századból
Authors: Buzási Enikő
Published: March 2018

The author presents some findings of the first inventorization of the painting collection in the episcopal palace in Pécs carried out in 2012: out of the inventoried 238 paintings, she publishes 134 in catalogue form until the end of the 19th century. These are the works of the collection that have adequate artistic quality, art historical significance or historical implications (awaiting further research as well). A great part of the collection has so far been unpublished, lacking name of painter, date of making, and often even accurate definition of the theme. The present publication arranging the items into historical and thematic units wishes to stop this gap, with the provenance of the pictures also given or suggested where there are sufficient clues for research. A considerable portion of works in the Pécs palace do not belong to the 18th, early 19th century furnishings of a bishop’s residence (Pécs, Mecseknádasd, Mohács). There are very many paintings removed from ecclesiastical function; they derive from the 19th century equipment of the church prior to the 1882 reconstruction, from the old chapel of the bishop’s palace, from the seminary chapel, and the monasteries of Franciscans, Sisters of Mercy or the nuns of Notre Dame. Several works were bequests or deposits from secular loci after World War II. A few were purchased from the art trade in the late 19th-early 20th century, first of all to decorate the palace. In addition to the inventorization of the stock and the dates of individual works, these conclusions could be inferred from three inventories of the equipment of the episcopal palace taken in 1777 and 1778 (after bishop György Klimó’s death) and in 1838 (after bishop Ignác Szepesy’s death), also used for the processing of the stock. In general it can be concluded that when issuing a commission, the choice was evidently the artists’ circle of the Viennese court from the baroque period and later of the Academy, and the acquisitions from the art trade later were also mostly of Viennese origin.

The catalogue is divided as follows: I. Portraits of ecclesiastic persons; II. Acquisitions and commissioned works of bishop György Klimó; III. Acquisitions and commissioned works of bishop Pál László Esterházy; IV. Commissioned works of bishop János Scitovszky and works from the 19th century equipment of the cathedral; V. Acquisitions and commissioned works of bishop Nándor Dulánszky; VI. Works that came into the episcopal palace after World War II; VII. Works of unknown provenance; VIII. Copies of pictures with miraculous powers; IX. Variants of copies from the 18th century and artistic replicas from the 19th century.
Adatok a magyarországi ötvösség történetéhez IX. Miskolc
Authors: Grotte András
Published: March 2018

In the earlier scientific literature dealing with the Hungarian masters’ mark (thus also in the book of Kőszeghy Elemér: Magyarországi ötvösjegyek a középkortól 1867-ig / Merkzeichen der Goldschmiede Ungarns vom Mittelalter bis 1867. Budapest 1936) the data about the smiths of Miskolc was corrupted, because it had been mixed up with the data about the smiths from other cities (eg. Munkács, today Mukačeve, Ucraine). The study includes the revision of the scientific literature about the smiths of Miskolc, and collects with an ambition of completeness all the data related to them. We have relatively few sources dating from the 16th-17th centuries, but the smiths begin to appear in written sources from the 18th century onwards. The appearing names are sometimes related to the works which are still around today. The study details many of these connections. The smiths of Miskolc were working organized into guilds. The Jewish smiths living in the city have joined the guild of masters of Jewish faith which was founded in 1836.
A prágai Szent Vitus-székesegyház királyi oratóriumának címersora közép-európai összefüggésben
Authors: Pálffy Géza
Published: March 2018

The study examines the series of coats of arms of the Hungarian and Bohemian Lands on the late Gothic Royal Oratory of the Cathedral of Saint Vitus in Prague in a Central European context. The analysis of the history of coats of arms of the Lands of the Hungarian Crown, principally that of Bosnia resulted in three new findings. On the one hand, contrary to previous concepts the creation of the series of coats of arms and along with this the completion of the oratory did not took place in the first half of the 1490’s, that is, at the beginning of the reign of Wladislaw, king of Hungary and Bohemia (1490–1516), but presumably in the 1510–1520’s. The occasion must have offered itself during the Bohemian sojourn of Louis II, king of Hungary and Bohemia (1516–1526) and his wife in 1522–1523, and presumably the coronation of Mary of Hungary in the Cathedral of Saint Vitus on June 6, 1522. On the other hand, the Bosnian coat of arms proves that the coats of arms of the Lands of the Hungarian Crown on the Royal Oratory were taken over from the heraldic representation of Emperor Maximilian I in Innsbruck instead of those of the Jagiellonian dynasty in Prague or Buda, where those were present on several such memorials from the late 1490s on (Wappenturm, Triumphzug, Ehrenpforte, etc.). Namely, at this time it was only in Habsburg heraldic representations that Bosnia was represented by the armored arm holding a sword, while in Hungarian practice the south Slavic kingdom’s coat of arms included two crowns. Thirdly, based on new research it can be stated that the coat of arms of Upper Lusatia, situated on the balustrade, could have been placed among the coats of arms of the Lands of the Hungarian Crown only during an erroneous restoration attempt at the end of the 19th century. Originally the coat of arms standing between those of the kingdoms of Dalmatia and Bosnia must have been that of Croatia whose checkered coat of arms was probably confused with the similar one of Upper Lusatia depicting a castle wall.
A „Steindl-füzetek”. Egy forrás a dualizmus kori építészképzés történetének historiográfiai megközelítéséhez
Authors: Salamon Gáspár
Published: March 2018

Imre Steindl (1839–1902) is thought to be one of the most prominent architects of the Hungarian Historicism, whose active contribution to the Hungarian Neo-gothic architecture and restoration practices can hardly be overestimated. Albeit, his activity as an architect of the renowned late chief work of the international Gothic Revival, the Hungarian Parliament, as a leader of a prosperous atelier and as a driving force in the public life of the Hungarian architects has been studied intensively, to his work as professor at the Joseph Technical University of Budapest has been so far less attention given. Steindl began to teach as an ordinary professor of medieval architecture in 1870 and shaped the curriculum and educational methods following the traditions of his former alma mater, the Academy Fine Arts of Vienna. In this study, beyond the outline of the long 19th-century Hungarian architectural education and analysis the educational principals typical of Steindl’s methods, the manuscript of the professor’s lecture notes is published and analyzed, with special regard to his historiographical orientation and scholarly reference points. The philological reading of the text points out, that Steindl compiled his lectures in question from the ‘great syntheses’ of the Berlin School of Art History, above all that of Wilhelm Lübke and Karl Schnaase. The detection of this kind of historiographical influence may contribute to the scholarship’s image of Steindl’s, furthermore the late 19th-century Hungarian architectural intelligentsia’s erudition.
Adalék Neményi Bertalan képzőművészeti gyűjteményéhez
Authors: Juhász Sándor
Published: March 2018

The Budapest lawyer Dr. Bertalan Neményi (1892-1947) was one of the notable figures of Hungarian art collection in the interwar period. He was mainly drawn to contemporary Hungarian artists, so he had considerable numbers of works by József Rippl-Rónai, Lajos Gulácsy and Tivadar Csontváry Kosztka. The reconstruction of his collection is very difficult as the bulk disappeared at the end of WWII. In early 1944 he deposited a considerable segment of his collection in thirteen locked wooden crates in the safe of the Hungarian General Credit Bank. The safe was left intact by the siege of the city, but the corps of the Soviet army specialized for gathering art works plundered the safe. On 19 March 1945 Neményi asked help for the search after his collection. The list included 98 paintings, some 350 graphic sheets and 2000 books. Several of his treasures were not put in the bank but in homes of private persons. When Neményi died unexpectedly in 1947, the existing pieces of the collection got into the art trade. Some were also found there from the stock once deposited in the bank. Most of the bank deposits, however, went to Moscow. The paper tries the reconstruct the collection and the intellectual portrait of the collector with the help of archival sources first published here.
Ichthyofauna from three streams of the lower Iguatemi River in the upper Paraná river basin, Brazil
Authors: Batista-Silva Valéria Flávia , Frota Augusto , Kashiwaqui Elaine Antoniassi Luiz , Abelha Milza Celi Fedatto , Bailly Dayani , Gubiani Éder André , Júnio da Graça Weferson
Published: March 2018

The ichthyofauna from 3 streams (Água Boa, Perobão, and Santa Maria) to the lower Iguatemi River were inventoried, which is located in the upper Paraná river basin, in Mato Grosso do Sul state, Brazil. Sites in the upper, intermediate, and lower portions of each stream were quarterly electrofished from March to December 2008. All sampled fish (n = 6,816 individuals) represented 43 species of 5 orders, and 16 families. The most abundant species was Phalloceros harpagos (63.5%), followed by Astyanax aff. paranae (10.6%), Hypostomus ancistroides (5.9%), Gymnotus inaequilabiatus (3.4%), and Knodus moenkhausii (2.7%). Despite the high ichthyofauna richness in the lower portion of Iguatemi River, the need to implement and/or expand soil conservation practices and riparian forest restoration is of utmost importance to maintain these populations in the long term.
Non-native reef fishes in the Southwest Atlantic Ocean: a recent record of Heniochus acuminatus (Linnaeus, 1758) (Perciformes, Chaetodontidae) and biological aspects of Chromis limbata (Valenciennes, 1833) (Perciformes, Pomacentridae)
Authors: Adelir-Alves Johnatas , Soeth Marcelo , Braga Raul Rennó , Spach Henry Louis
Published: March 2018

In the present paper, we document a recent record of the Bannerfish, Heniochus acuminatus, an Indo-Pacific species, in the southwest Atlantic Ocean and comment on biological aspects of the Azores Chromis, Chromis limbata, an invasive reef fish in the western Atlantic Ocean. We suggest that investigations of invasive species along the Brazilian coast can use data provided by citizen science, strengthening the non-native reef fish control strategies.
Expanding the geographical distribution of Astyanax biotae Castro & Vari, 2004 (Characiformes, Characidae), with comments on its conservation status
Authors: Oliveira Carlos Alexandre Miranda , Oliveira Anielly Galego de , Pavanelli Carla Simone
Published: March 2018

Astyanax biotae Castro & Vari, 2004 was only known from the type locality, a first-order stream from the lower Paranapanema River, a left bank tributary from the upper Paraná river basin. We report A. biotae from the Ivinhema River, rio do Peixe and other tributaries of Paranapanema River, expanding its distribution to both margins of the Paraná River. Astyanax biotae is zooplanktivorous and regarding its conservation status, can be classified as Least Concern.
ANALYSIS DINAMIKA SPASIAL DAN TEMPORAL PENGGUNAAN LAHAN DAN IMPLIKASINYA TERHADAP SEDIMENTASI DI WILAYAH PESISIR DAS CITARUM
Authors: - Paryono , Suryo Sukoraharjo Sri , Damar Ario , Budi Susilo Setyo , Dahuri Rokhmin , Suseno Heny
Published: March 2018

Upaya mengelola wilayah pesisir akan efektif jika diikuti pengelolaan di Daerah Aliran Sungai (DAS) di atasnya, karena perubahan penggunaan lahan di DAS akan berdampak pada sedimentasi di wilayah pesisir. Pengelolaan wilayah pesisir secara efektif membutuhkan kajian keterkaitan penggunaan lahan di wilayah DAS  terhadap sedimentasi di wilayah pesisir. Penelitian ini bertujuan menganalisis : (a) perubahan luas penggunaan lahan di DAS Citarum bagian hilir; (b) luas sedimentasi di sekitar muara Sungai Citarum; (c) hubungan antara perubahan luas penggunaan lahan dengan luas sedimentasi.   Lokasi penelitian  di DAS Citarum bagian hilir. Perhitungan luas penggunaan lahan dan luas sedimentasi menggunakan analisa citra satelit. Hasil perhitungan luas penggunaan lahan  menunjukkan  terjadi perubahan luas penggunaan lahan  di DAS Citarum bagian hilir dari tahun 2000 - 2014 secara signifikan, yaitu : (1) terjadi peningkatan luas penggunaan lahan non-vegetasi; (2) terjadi penurunan luas lahan sawah;  dan (3) terjadi penurunan luas lahan bervegetasi. Hasil perhitungan luas area sedimentasi di sekitar muara Sungai Citarum menunjukkan peningkatan luas sedimentasi tahun 2000 - 2014.  Analisa keterkaitan antara luas sedimentasi dengan berbagai luas penggunaan lahan yaitu : (1)  semakin luas lahan  bervegetasi maka semakin kecil luas sedimentasi; (2) semakin luas lahan non-vegetasi maka luas sedimentasi makin besar ; (3)   peningkatan luas lahan sawah berdampak pada penurunan luas sedimentasi.  Dari berbagai faktor tersebut, faktor yang berpengaruh nyata terhadap peningkatan sedimentasi adalah  faktor lahan bervegetasi. Hasil pemodelan perhitungan luas penggunaan lahan di DAS Citarum hilir  yang berdampak pada luas sedimentasi paling kecil terjadi jika curah hujan maksimum dan luas sawah minimum dengan komposisi luasan yaitu luas sawah sebesar 124.796 hektar dari kisaran 124.796 - 179.416 hektar, luas lahan bervegetasi maksimum 92.134 hektar dari kisaran 71.015 - 92.134 hektar,  dan luas lahan non vegetasi 76.000 hektar dari kisaran 40.000 - 90.000 hektar.
Emphasizing High Value, Cost-Effective Care in Physical Examination Instruction – A Qualitative Content Analysis of Interviews with Expert Educators
Authors: Bergl Paul A. , Farnan Jeanne M. , Chan Evelyn C.Y.
Published: March 2018

This article was migrated. The article was marked as recommended. IntroductionPhysical examination and cost consciousness are critical competencies for medical trainees, but the intersection of these two skill domains is not described. We aimed to elucidate the role of physical examination in providing high value, cost conscious care (HVC) and to explore how clinical skills curricula could integrate principles of HVC.MethodsWe conducted a qualitative study of semi-structured interviews with 20 experts in the instruction and clinical applications of physical examination. We identified experts through purposeful sampling and snowball sampling. Audio-recorded interviews were coded using qualitative content analysis. Coded passages were categorized and reported as key themes and recommendations.ResultsExperts affirmed physical examination's indispensable role in clinical reasoning. When integrated with history-taking and additional diagnostic data, physical examination can further the aims of HVC. However, experts noted that the pace and demands of contemporary clinical practice present barriers to the idealized application of physical examination. In turn, participants discussed how to improve clinical skills curricula, both broadly and to promote HVC.DiscussionTo advance HVC through physical examination curricula, the clinical relevance of bedside skills needs to be emphasized across the training spectrum. Key strategies include revisiting evidence-based medicine principles and integrating physical examination instruction with teaching clinical reasoning.
Relationship between dry matter content at harvest and maturity index and post-harvest quality of ‘Fuji’ apples
Authors: Vieira Marcelo José , Argenta Luiz Carlos , Mattheis James Peter , Amarante Cassandro Vidal Talamini do , Steffens Cristiano André
Published: March 2018

Abstract Two experiments were carried out to evaluate the relationship between dry matter content (DMC) and maturity index of ‘Fuji’ apple fruit sports (‘Mishima’, ‘Fuji Select’ and ‘Fuji Suprema’) during the final stage of fruit growth, and the relationship between DMC at harvest and the post-harvest fruit quality. Fruit were harvested from orchards of three regions (Caçador, São Joaquim and Vacaria), on two rootstocks (M9 and Marubakaido with M9 interstock). In experiment 1 (2014), fruit were periodically sampled beginning 83 days before the commercial harvest period. In experiment 2, fruit were harvested at optimum maturity for long-term storage and stored in air at 0.5 ºC (2014) or after optimum maturity for long-term storage and stored in controlled atmosphere at 0.7 ºC (2014 and 2015). Apple fruit maturity on the tree was characterized by decreased flesh firmness and increased starch index and soluble solids content (SS) and by a small change in DMC. DMC at harvest was correlated with flesh firmness and SS in one of two years, but DMC was not correlated with the incidence of disorders after storage. The results show that DMC at harvest is not suitable as a maturity index of ‘Fuji’ apples, and its use as a post-harvest quality predictor is not consistent between crop years.
Life cycle, survivorship and life expectancy of foliage spider (Marpissa bengalensis) in citrus orchard
Authors: Nawab Muhammad , Lashari Mushtaq Hussain
Published: March 2018

ABSTRACT: The post embryonic developmental stages of Marpissa bengalensis (Araneae; Salticidac), the 2nd most abundant predatory species in citrus orchard were collected from the experimental fruit garden, department of Horticulture, located at the campus of University of Agriculture Faisalabad andstudied. Life cycle was observed in the laboratory, which started from egg sac collected from the field along with gravid female and released into the spider cages. The incubation period ranged from 5-15 days. The average eggs hatched were 23.8 eggs/cocoon and hatching % under laboratory conditions was recorded as 73.18%. The average duration of spiderlings span on their mothers back was 7 days. An overall, mean duration of 3rd spiderling stage was of 7.46 days. All spiderlings hatched from 8 cocoons. At the 4th spiderling stage, the average duration was of 10.23 days. In the 5th spiderling stage, the spiderling spent an average of 19.82 days. The 6th and 7th spiderlings stages lasted a total of 23.14 days and 25.86 days respectively. During 8th spiderling stage, the duration was maximum and it was recorded in 28.08 days. On average, from hatching to adult stage, the spiderlings lasted 137 days to attained maturity. Greater mortality was observed in the 3rd and 4th spiderling stages, decreasing thereafter and reaching zero in the 8th spiderling stage.
Dynamics of change in fermentation and fatty acid profiles in high moisture alfalfa silage during ensiling at different temperatures
Authors: Liu Qinhua , Dong Zhihao , Shao Tao
Published: March 2018

ABSTRACT: The objective of present study was to investigate the dynamics of change in fermentation and fatty acid profiles in high moisture (DM=232g/kg FW) alfalfa silages during ensiling at 45°C, 30°C and 15°C. After ensiling for 1, 3, 7, 21, 39 and 65 days, silages was sampled and examined. Lactic fermentation changing into butyric fermentation in silage ensiled at 30°C and 45°C occurred on ensiling for 21 and 65 days, respectively, as accompanied with high ammonia-N content ( >150g/kg N), which subsequently resulted in a sudden increase of pH (P < 0.05). In contrast, the increase of lactic acid content was observed in silage ensiled at 15°C during ensiling for 65 days (P<0.05). As the ensiling temperature rose, considerable losses in total FA, C18:2n6 and C18:3n3 increased after ensiling for 1 day as compared with alfalfa before ensiling (P < 0.05) mainly due to thermolability of polyunsaturated FA and multiplication of lactic acid bacteria. Contents of total FA, C18:2n-6 and C18:3n-3 fluctuated in silage stored at 30°C and 45°C during ensiling from 3 to 65 days (P < 0.05), but decreased at 15°C due to the intervention of aerobic bacteria, yeasts and lipoxygenase. Therefore, after ensiling for 65 days, high moisture alfalfa silage ensiling at 15°C had better fermentation quality than at 30°C and 45°C. Temperature had significant influence on dynamics of change in FA profile in alfalfa silage during ensiling.
A PERCEPÇÃO DE HOMENS E COMPANHEIRAS ACERCA DA DISFUNÇÃO ERÉTIL PÓS-PROSTATECTOMIA RADICAL
Authors: Azevedo Cissa , Mata Luciana Regina Ferreira da , Braga Patrícia Pinto , Chavez Giannina Marcela , Lopes Matheus Ramos , Penha Carolina Sousa
Published: March 2018

RESUMO Objetivo: analisar a percepção de pacientes prostatectomizados e de suas companheiras acerca dos desafios vivenciados após a cirurgia, relacionados à sexualidade do casal e aos efeitos da disfunção erétil. Método: estudo descritivo-exploratório, de abordagem qualitativa com coleta de dados a partir de um roteiro semiestruturado aplicado com nove casais. A análise dos dados ocorreu por meio do levantamento de unidades de sentidos e formação de categorias empíricas a partir do referencial da Teoria Social Cognitiva. Resultados: o tempo de realização da prostatectomia variou entre um ano e oito meses a três anos e dois meses. Dentre os homens, a média de idade foi de 65 anos e das mulheres 59 anos. O processo de análise dos dados permitiu a identificação de duas categorias empíricas e os resultados apontam que os desafios enfrentados pelos pacientes se referem à dificuldade de diálogo e ao distanciamento entre o casal e a consequente introspecção dos homens, a preocupação com o fator idade, o medo de abandono e a insegurança dos homens quanto ao uso de medidas terapêuticas para recuperação da capacidade de ereção. Entretanto, outros casais vivenciaram aspectos positivos baseados na compreensão e apoio psicológico, e até mesmo em mudanças na forma de pensarem e viverem após a cirurgia. Conclusão: a cirurgia de prostatectomia gera repercussões no cotidiano dos pacientes e de suas companheiras, sendo que a percepção do casal em relação às implicações da cirurgia é fator determinante no processo de recuperação e enfrentamento dos desafios advindos do tratamento.
Structural, Conformational and Spectroscopic Properties of C16H16BrNO3 Schiff-Base Molecule: A Theoretical Investigation
Authors: EVECEN Meryem
Published: March 2018

The Schiff- bases compound C16H16BrNO3 molecular geometry, vibrational frequencies and electronic properties(total energy, dipole moment, electronegativity, chemical hardness and softness) were investigated using DFT(B3LYP) method. Besides, the conformational analysis was made with respect to selected degrees of torsional freedom τ(C3-C2-C1-N1)torsional. Molecular electrostatic potential (MEP), frontier molecular orbital energies and NBO analysis of molecule have been performed by using Gaussian 09W program. The NLO analysis indicates that this molecule can be evaluated as an attractive object for nonlinear optical material studies.
Numerical Solutions of the Gardner Equation via Trigonometric Quintic B-spline Collocation Method
Authors: ERSOY HEPSON Özlem
Published: March 2018

The main purpose of this paper is to get the numerical
solutions of the Gardner equation which are widely used in various disciplines.
For this purpose, the time integration of the system is achieved by the
classical Crank-Nicolson method owing to its large stability region. Space
discretization is done by using the trigonometric quintic B-spline functions.
Thus the Gardner equation turns into a penta diagonoal matrix equation and the
Thomas algorithm is applied.
Quick Protocol for Monarch® Plasmid Miniprep Kit (NEB #T1010) v2
Authors: England Biolabs New
Published: March 2018

This is the quick version of the Monarch® Plasmid DNA Miniprep Kit Protocol (NEB #T1010). For the full protocol, please clickhere.
EXPERIENCE OF UTERINE ARTERY EMBOLIZATION IN UTERINE ARTERIOVENOUS MALFORMATION
Authors: Levakov S A , Kedrova A G , Nechayeva O E , Sitnikov A V , Lebedev D P , Kaganovskaya L M , Wanke N S
Published: March 2018

Uterine arteriovenous malformation (AVM) is a rare condition. Congenital AVMs have multiple vascular connections, may manifest at other sites, and involve surrounding structures, whereas acquired AVMs usually have a single connection between an artery and a vein. AVMs may be diagnosed by Doppler ultrasonography, computed tomography, magnetic resonance imaging and angiography. The article presents the literature and case report of AVM with the tactics of treatment of rare diseases.
MASTODYNIA: POSSIBILITIES OF THERAPY USING MICRONIZED PROGESTERONE
Authors: Prilepskaya V N , Bebneva T N
Published: March 2018

Pain in the mammary gland (mastodynia) is one of the most common complaints, with which women address themselves to a gynecologist. Mastodynia might be conditioned by various causes: inflammation process, hormonal imbalance, intake of varied groups of medication, including hormonal contraceptives, tumors, intercostal neuralgia, etc. The article presents current data on prevention of the appearance and possible therapies of mastodynia.
RADIOFREQUENCY ABLATION WPW SYNDROME IN PATIENT WITH EBSTEIN'S ANOMALY
Authors: Ardashev A V , Zhelyakov E G , Rybachenko M S , Konev A V
Published: March 2018

The case history of 19-year old patient with Ebstein's anomaly and WPW syndrome, which was held surgical correction of cardiac arrhythmias by radiofrequency ablation is described. 3-year observation of patient confirmed the success of the operation – absence episodes of arrhythmia
CELLULAR TECHNOLOGIES IN TREATMENT OF LUNG DISEASES – ARE WHETHER PROSPECTS?
Authors: Averyanov A V , Konoplyannikov A G
Published: March 2018

In the article the problem of treatment of lung pathology by cellular technologies is analyzed. Results of experiments, giving hopes for positive outcomes of clinical trials are summarized. Possible mechanisms of influence stem cells on regenerative processes in lungs are considered.
A CASE OF TREATMENT OF PRIMARY HIP REPLACEMENT COMPLICATION
Authors: Chesnikov S G , Dedyaev S I , Timoshenko M E , Borondzhiyan T S
Published: March 2018

Authors described a case of postoperative complications after total hip replacement. Joint replacement and reconstruction of the defect at the bottom of the acetabulum allowed to recover the architecture of the joint.
EFFECT OF METABOLIC DISORDERS IN THE COURSE OF OSTEOARTHRITIS
Authors: Artemenko N A , Ter-Ananyants E A , Mashtalova O G
Published: March 2018

The aim of this study was to examine the influence of obesity on the course of osteoarthritis (OA) in women. Material and methods: 83 women diagnosed with OA were divided into 2 groups. Group 1 (51 patients) with BMI ≥ 30 kg/m 2; Group 2 (32 patients) with BMI <30 kg/m 2. Objectification of symptoms was achieved by using a VAS (visual analogue scale) and index WOMAC. Blood levels of Creactive protein (CRP) and interleukin6 (IL6) also determined. Results: moderate direct relationship between BMI and severity of pain by VAS (r = 356, p = 0,027) was revealed. Excessive body weight (group 2) was established a very close relationship between the change in the index of pain by VAS and difficulties in performing daily activities (B WOMAC) (r = 0,971, p = 0.28). In both groups of patients with OA, regardless of BMI, there was the high level of CRP and IL6. Women with a degenerativedestructive joint disease obtained a very close relationship between IL6 and severity of pain by VAS (r = 0,99; p = 0,23). In patients with OA 2 groups revealed a strong relationship (r = 0,84, p = 0.002) between the rates of CRP and IL6 and significant relationship (r = 0,67, p = 0.006) between these same indicators in women with BMI <30 kg/m 2. Conclusions: The course of OA in women with excessive body weight is accompanied by more marked pain syndrome, increased levels of biomarkers of systemic inflammation, significant functional impairment and frequent development of synoviitis of the knee.
CANCER PATIENTS THYROID AND GLUCOCORTICOID HOMEOSTASIS IN METASTATIC BRAIN DISEASE
Authors: Airapetov K G
Published: March 2018

Blood concentration of hormones – stress indicators has been studied in patients with metastatic brain disease at pretreatment stage. Pronounced deviations of glucocorticoid and thyroid homeostasis have been observed in these patients. Dependence of hormonal parameters dynamics on extension of cerebral and extracranial metastasizing has been revealed.
CYSTIC KIDNEY DYSPLASIA IN INFANTS
Authors: Todorov S S
Published: March 2018

Cystic kidney dysplasia (CKD) in infants is a rare congenital pathology, associated with connective tissue dysplasia. Three autopsy cases of CKD reveals disturbance proportions of connective, fat, chondroid tissue with dominance cells and fibers of connective tissue. Kidney cysts formation with CKD, under our opinion, is secondary process due to compression few kidney tubules by undeveloped mesenchymal tissue.
CRITERIA OF CENTRAL MEDICAL SANITARY UNIT № 119 FMBA OF RUSSIA FOR TEMPORARY DISABILITY EXPERTISE
Authors: Kulyga V N , Mishin N R
Published: March 2018

The article presents the original criteria developed in CMSU № 119 FMBA of Russia for an objective evaluation of this important area of medical unit as expertise of temporary disability.
SURGICAL CORRECTION OF IDIOPATHIC SCOLIOSIS BY ROD SYSTEM
Authors: Agzamov D S , Sampiev M T , Laka A A , Balashov S P , Karimov R F , Tkalin A N
Published: March 2018

In this article the results of surgical treatment of 150 patients with adult idiopathic scoliosis are presented. We used a rod instrumentation LSZ-3 of full and selective fusion of primary curve. Application of the core endocorrector LSZ-3 allowed to reduce the traumatism of surgical treat- ment and the risk of fatigue fractures of endocorrector components. This method improved both the physical adaptation of the patients after the operation and their quality of life.
NEW METHOD FOR NON ALLERGIC SPACE MODELLING DURING SLEEPIN PATIENTS WITH ATOPIC ASTHMA
Authors: Averyanov AV Vyacheslavovich , Ilina NI Ivanovna , Sokurenko SI Ivanovich , Shartanova NV Vladimirovna , Borisova TV Vadimovna , Tretyak AA A
Published: March 2018

The results of the clinical trial of a new air cleaning method in the breathing zone of the patient with asthma exacerbation are presented. It is shown that in patients treated with additional tech- nology Protexo®, the bronchodilators usage and dispnoe score significantly reduced. Significant effects on respiratory parameters has not been established.
PROMISING PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY
Authors: Strakhovskaya M G , Belenikina N S , Nikitina V V , Kovalenko S Yu , Kovalenko I B , Averyanov A V , Rubin A B , Galochkina T V
Published: March 2018

A photosensitizer from polycationic metallophthalocyanines class is shown to have a high antimicrobial activity and a wide antimicrobial spectrum. It is established that the effective pho- todynamic inactivation of bacteria in the presence of photosensitizer of polycationic nature is determined by its electrostatic binding to negatively charged structures of bacterial cell walls. The usage of antimicrobial photodynamic therapy in medical practice is discussed from the point of view of the obtained results.
CELL TECHNOLOGIES AND TISSUE ENGINEERING IN THE TREATMENTOF ARTICULAR CHONDRAL DEFECTS
Authors: Sovetnikov N N , Kalsin V A , Konoplyannikov M A , Mukhanov V V
Published: March 2018

A review of literature considers the problem of hyaline cartilage biology and repair following by injury, and surgical repair of cartilage defects. Repair techniques based on direct cartilage substitution (mosaicplasty, osteochondral allotransplantation, minced cartilage autotransplantation in gel), bone morrow stimulation techniques (abrasion, drilling, microfracture, matrix-induced chondrogenesis) were characterized in terms of biology and clinics. Most attention was addressed to cell technology and tissue engineering.
SYSTOLIC FUNCTION AND DYSSYNCHRONY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Authors: Yaroschuk N A , Kochmasheva V V , Dityatev V P , Kerbikov O B
Published: March 2018

Echographic evaluation of systolic function plays an important role in examination of the patients with acute myocardial infarction (AMI). Recent developments in real-time 3D echocardiography (RT3DE) allow us to evaluate additional parameters such as the dyssynchrony.The aim of this study was to evaluate the relationship between myocardium dyssynchrony and systolic function and to assess the prognostic value of dyssynchrony and its influence on the development of arrhythmias and fatal event in post AMI period.Methods: Study population consisted of 82 (mean age 52±21) patients with AMI and 65 age and gender matched persons with similar cardiovascular risk factors, but without AMI (control group). Standard deviation of the time to the regional LV minimum systolic volume for all 16 segments Tmsv4 16-SD index was used for the assessment of dyssynchrony. The follow-up period was 6 months afterAMI.Results: Tmsv 16-SD values were significantly higher in patients with MI compared control group (6.8 ± 2.7% vs 2.9 ± 1.6 % respectively, р<0,001). Moderate negative correlation was observed between Tmsv 16-SD and Cardiac Index (CI) (r =-0.58, p<0.008). No significant correlations were found between Tmsv 16-SD and mean arterial pressure and herat rate. Tmsv 16-SD was significantly lower in patients with pulmonary hypertension (maximum systolic pressure in lung artery (SPLA) – 55.0±5.58 mm Hg) as compared to patients without pulmonary hypertension (maximum SPLA – 33.0±5.76 mmHg); 4.9±0.75 vs 6.1±1.88 respectively, р=0.03. Significant positive correlation was observed between Tmsv 16-SD and end-diastolic volume (EDV) (r=0.63; р<0.05) and negative with ejection fraction (EF) (r=-0.73; p<0.05).28 patients (34%) of the MI group had the increase Tmsv 16-SD and normal values of EDV and EF. According to ROC analysis ROC Tmsv 16-SD>6.1 was associated with arrhythmic complications in post IM period (sensitivity 83.3%, specificity 87.5%, AUC=0.865, p<0.0001). Tmsv 16SD>6.1 correlates with increasing likelihood of fatal event (sensitivity 87.5%, specificity 71.6%, AUC=0.81, p<0.0001)Conclusions: Tmsv 16-SD is increased in patients with MI. In 34% of MI patients the increase of Tmsv 16-SD was observed in combination normal values of EF and EDV which allow us to consider Tmsv 16-SD as an additional indicator describing pathological changes in myocardium. Tmsv16-SD is correlated with hemodynamic indicators such as CI and SPLA. High Tmsv 16-SD is associated with increased level of arrhythmic complications and fatal events.
PROBLEMS OF DIFFERENTIAL DIAGNOSIS OF BRONCHIOLOALVEOLAR CARCINOMA
Authors: Urazovsky N Y , Averyanov A V , Lesnyak V N
Published: March 2018

The review presents the modern view on bronchioloalveolar carcinoma. The most attention is paid to the CT as one of the most important methods of primary diagnosis. Authors showed distinctive features of diseases that have similar X-ray picture.
THE AFFECT OF INFLUENCE OF GENES' POLYMORPHISMS CYP2C9 AND VKORC1ON THE SAFETY OF THE THERAPY BY WARFARIN
Authors: Zotova I V , Nikitin A G , Fattakhova E N , Brovkin A N , Khodyrev D S , Lavrikova E Y , Isaeva M Y , Kosukhina A S , Nosikov V V , Zateyshchikov D A
Published: March 2018

To study the distribution of alleles and genotypes of polymorphic markers of genes CYP2C9 and VKORC1 of Russian patients who live in Moscow, and in order to assess the influence of genetic factors on warfarin therapy 400 patients have been genotyped. The dosage of warfarin which is required for achievement of INR target values has been different among owners of different geno- types of polymorphic markers of genes CYP2C9 . Meanwhile the highest average dose has been required for genotype *1/*1 and the lowest – for owners of alleles *2 and *3 . For polymorphism G(- 1639)A of the gene VKORC1 the dosage of warfarin which is required for achievement of the INR target values, has been different among owners of different genotypes. The highest average dose has been required for genotype GG, and the lowest – for genotype AA. The results will allow to work out more accurate algorithm of choosing of the initial dose of warfarin depending on the genotypes of polymorphic markers of genes CYP2C9 and VKORC1.
THE OPTIMIZATION OF DIALYSIS PROGRAM FOR UREMIC POLYNEUROPATHY TREATMENT
Authors: Fedoseev A N , Shestakov V V , Vaulin I N , Vaulina A S , Smirnov V V , Krutova T N
Published: March 2018

The impact of changes dialysis program on ENMG rates in patients with a terminal stage of chronic renal insufficiency receiving regular dialysis treatment was studied. The study made it possible to determine that the strengthening of the dialysis program with the increase in KT/V to 1.4 promotes regression of neurological manifestations of uremic polyneuropathy and improvement of neurophysiological indicses of functioning of the peripheral nerves in patients with a terminal stage of chronic renal insufficiency. Significantly improved indicators of functional activity as axial cylinders of the peripheral nerves and the myelin sheath. Optimisation of dialysis program allows to improve the functional activity of peripheral nerves already by the end of the first month, the maximum therapeutic effect at 6month treatment and to obtain the steadfast compensation sensory and motor deficit of uremic polyneuropathy. Thus, for the correction of uremic polyneuropathy it is expedient to strengthen the dialysis program with the increase in KT/V to 1.4.
FACILITIES OF HELICAL CT IN DIAGNOSTIC OF DIAPHRAGMATIC INJURIES AND ITS CONSEQUENCES
Authors: Zvezdkina E A , Lesnyak V N , Belov M A , Kochanova M N
Published: March 2018

Diaphragmatic injuries are quite uncommon and often result from either blunt or penetrating trauma. Acute traumatic rupture of diaphragm may be unrecognized and there is often a delay between the injury and the diagnosis. This article reviews the case reports of three patients. The first patient had a penetrating trauma of left diaphragm. The diagnosis was made 5 days later. The second patient had herniation with kidney, colon and intestine through the left diaphragmatic rupture. The third patient had right diaphragmatic rupture and herniation with hepar, сolon and stomach. Both cases were presented as early undiagnosed injuries.
ASSOCIATION OF THE POLYMORPHISMS OF THE TCF7L2 GENES WITH TYPE 2 DIABETES
Authors: Nikitin A G , Potapov V A , Brovkin A N , Lavrikova E Yu , Khodyrev D S , Shamhalova M Sh , Smetanina S A , Suplotova L N , Shestakova M V , Nosikov V V , Averyanov A V
Published: March 2018

To study the association with diabetes mellitus type 2 we performed analysis of the distribution of frequencies of alleles and genotypes two polymorphic markers of TCF7L2 gene. The study included groups of T2DM patients and unrelated controls of Russian origin. Analysis of the distribution of frequencies of alleles and genotypes of the polymorphic marker rs7903146 of TCF7L2 gene showed the presence of association with T2DM in Russian population, while for the marker rs12255372 was not found statistically significant associations with type 2 diabetes. We can conclude that in Russian population TCF7L2 gene is associated with development of T2DM.
ULTRASOUND CRITERIA FOR DIAGNOSIS AND MONITORING OF DRUG THERAPY OF COMBINED PROLIFERATIVE DISEASES OF THE UTERUS
Authors: AG Kedrova Genrikhovna , SA Levakov Aleksandrovich , OE Nechaeva Evgen'evna , RH Tazitdinov Khallilovich , NN Chelnokova Nikolaevna
Published: March 2018

The aim of the paper was to evaluate the diagnostic accuracy of transvaginal tenderness-guided ultrasonography in the identification of location of genital endometriosis, endometrial hyperplasia and uterine fibroids before and after treatment dienogest. It is a selective progestin for the treatment of endometriosis. Adenomyosis was diagnosed when a poorly defined area of abnormal echo-texture (decreased or increased echogenicity, heterogeneous echotexture, myometrial cysts) presented in myometrium. Typical ultrasonic changes of efficacy were: homogeneity of myometrium; clear and intense contours of uterine fibroid with increased echogenicity; reduction of the echogenic endometrial stripe with the average echogenicity and clear lines of myo- and endometrium with a reduction in local blood. These criteria can be used to select non-surgical management of patients. In cases where a poorly defined area of abnormal echotexture (decreased or increased echogenicity, heterogeneous echotexture, myometrial cysts) did not change the surgery or the embolization of artery uterine is required. The preferred imaging modality for the evaluation of uterine on therapeutic alternatives to hysterectomy and myomectomy is transvaginal ultrasonography.
POLYSEROSITIS AS A MASK OF PARAPROTEINEMIC HEMOBLASTOSIS
Authors: Novikova O N , Alekseeva N V , Rudenko E A
Published: March 2018

The article describes the rare clinical case of Waldenstr`m's macroglobulinemia in combination with primary amyloidosis which main clinical symptom is polyserositis. The diagnostic difficulties of this case are described.
CLASSIFICATION, DIAGNOSIS, AND APPROACH TO TREATMENT FOR ANGIOEDEMA
Authors: Borisova T V , Sokurenko S I
Published: March 2018

Angioedema is defined as localized and self-limiting edema of the subcutaneous and submucosal tissue, due to a temporary increase in vascular permeability caused by the release of vasoactive mediators. When angioedema recurs without significant wheals, the patient should be diagnosed to have angioedema as distinct disease. In the absence of the accepted classification, different types of angioedema are not uniquely identified. Four types of accuired and three types of hereditary angioedema were identified as separate forms from the analysis of literature. Here, we summarize the data and the resulting classification and treatment of angioedema.
IMMUNOLOGICAL DISODERS IN PATIENTS WITH CHRONIC RENAL INSUFFICIENCY AND POSSIBILITY OF IMMUNE THERAPY
Authors: Sokurenko S I , Fedoseev A N , Borisova T V
Published: March 2018

The main evidence of the participation of immune responses in the pathogenesis of chronic renal failure (CRF) is an undoubted effect of treatment with corticosteroids, alkylating agents and cyclosporine A. This is supported by the relationship of nephrotic syndrome (NS) with atopy, Hodgkin's disease, certain HLA-types: DRw7, B12.This article presents a review of the literature, focused on the immunological changes in patients with impaired renal function, including сhroniс hemodialysis. Various aspects of immunocorrection in patients with chronic kidney disease are analyzed.
EPIDEMIOLOGIYa VNEZAPNOY SERDEChNOY SMERTI: ChTO MY ZNAEM SEGODNYa?
Authors: Boytsov Sergey Anatol'evich , Linchak Ruslan Mikhaylovich , Nedbaykin Andrey Mikhaylovich , Sementsova E V , Yusova I A , Strukova I V
Published: March 2018

The prevalence of sudden cardiac death in the United States and European countries is very high, reaching 1‰ in population. Its share in the total mortality rate is around 13%, in the structure of cardiovascular mortality - about 40%. The lack of official statistics and large multicenter studies in our country do not allow us to estimate the true extent of the problem, but based on the calculated data, we can suppose that annually 200-250 thousand people died suddenly in Russian Federation. This question becomes especially important in working age population - the most significant economic and social part of society. In this population the proportion of sudden cardiac mortality can exceed 50%, and the features of nosological structure require different approaches for prevention, both at individual and population level.
SYNCOPE AS SUDDEN CARDIAC DEATH RISK FACTOR
Authors: Tyurina T V
Published: March 2018

The article analyses the link of syncope and sudden cardiac death risk with primary diagnosis. The data of dependency between syncope and risk of sudden cardiac death and mechanism of syncopal episodes is presented. The criteria of syncope with high sudden cardiac death risk are given. The article also provides an algorithm of syncopal episode diagnosis according to the ESC Guidelines (2009).
ARTHROSCOPIC RECONSTRUCTION OF ROTATOR CUFF, HAGL AND SLAP LESIONS IN OVERHEAD-THROWING ATHLETE
Authors: Agzamov D S , Akhpashev A A , Sovetnikov N N
Published: March 2018

Authors present the unique case report of concomitant rotator cuff injury, HAGL and SLAP lesions in overhead-throwing athlete. Rare HAGL lesion was compared on MRI image and at arthroscopy findings. Indications for reconstructions were elaborated of publication guidance’s. All three injury was treated operatively in one surgery according up-to-date recommendations.
ARTHROSCOPY-ASSISTED ANATOMICAL STABILIZATION OF CHRONIC ACROMIO-CLAVICULAR SEPARATION
Authors: Agzamov D S , Mukhanov V V , Sovetnikov N N , Akhpashev A A , Tkalin A N , Karpashevich A A
Published: March 2018

Authors have analyzed publications about current treatment of chronic acromioclavicular separation and have concluded the optimal approach for treatment of the injury. Case report presents implication of up-to-date concepts of chronic acromioclavicular separation treatment. Surgical technique, that is minimal invasive, biocompatible and maximal restores native biomechanics is described in details.
PRIMARY AND METASTATIC MUCINOUS OVARIAN CANCER. DIAGNOSTIC DIFFICULTIES AND NEWDEVELOPMENTS IN TREATMENT
Authors: Kedrova A G , Shablovsky О R , Zabozlaev F G , Nechaeva О E , Krasilnikov S E , Maksimenko T A , Gerasimov A A
Published: March 2018

In order to improve the results of treatment of patients with malignant ovarian tumors the clinical, morphological and genetic characteristics of mucinous tumors were analyzed. There are 4 cases of mucinous ovarian tumors: the case of mucinous cystadenocarcinoma ovarian associated with dermoid cyst; the case of the giant metastases to ovarian from colorectal mucinous adenocarcinoma; the case of mucinous metastases to ovarian associated with malignant mesotheliomas; the case of the low-grade mucinous neoplasm (mucinous cystadenocarcinoma of the appendix) presented with pseudomyxoma peritonei and mucinous ovarian tumor.
EXPERIENCE IN THE TREATMENT OF IATROGENIC DAMAGE OF THE URETERS
Authors: Shirshov V N , Doronchuk D N , Shatirishvily O Ê , Konstantinova I M , Obolonkov V Yu , Lebedev Yu I
Published: March 2018

The article discusses the literature data and clinical cases in the author’s hospital of iatrogenic injuries of ureters following the pelvic surgery, the diagnosis and the treatment.
THE CASE OF SUCCESSFUL SIMULTANEOUS SURGICAL TREATMENT OF POSTINFARCTION VENTRICULARSEPTAL RUPTURE AND ANEURYSMS OF THE RIGHT AND LEFT VENTRICLES
Authors: Zotov A S , Puzenko D V , Klypa T V , Shin A R , Khabazov R I
Published: March 2018

We report a clinical case of successful simultaneous surgical repair of postinfarction ventricular septal rupture, aneurysm of the right ventricular posterior wall and aneurysm of the left ventricular apex combined with three-vessel coronary artery bypass grafting in a 76-year-old patient .
ThE uSE of AbErrAnT METhylATEd gEnES SEPT9 And VIM for clInIcAl dIAgnoSIS of colorEcTAl cAncEr
Authors: Brovkina O I , Gordiev M G , Khodyrev D S , Nikitin A G , Averyanov A V
Published: March 2018

Definition of epigenetic disorders is important for early diagnosis of colorectal cancer. To obtain a model of diagnostic test system with high sensitivity and specificity, we determined the frequency of methylation in SEPT9 and VIM genes. Epigenetic events also were compared with mutations in the RAS family genes. It was confirmed the presence of aberrant methylation in SEPT9 and VIM genes in tumor cells. DNA of tumor samples was significantly more methylated than samples with DNA from adjacent tissue (P = 8,67E-19 for SEPT9 gene and P=8,68E-19 for VIM gene). In the group of patients carried mutations in KRAS or NRAS genes tumor DNA significantly more methylated in gene SEPT9 (P = 0.0018), in contrast to the tumor DNA from patients not carried mutations. We have demonstrated that the combined use of methylation markers can improve the sensitivity of the test systems used in the diagnostics of colon cancer.