bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of River Blocking Induced by a Debris Flow
Authors: Wang Lijuan , Chang Ming , Dou Xiangyang , Ma Guochao , Yang Chenyuan
Published: September 2017

Both the Wenchuan earthquake on May 12, 2008, and the Lushan earthquake on April 12, 2013, produced many coseismic landslides along the Nanya River in Shimian City. Subsequent debris flows that initiated from these landslides and are triggered by intense rainfall become the secondary hazard in the years after the earthquake; in particular, some debris flows led to a serious river blocking event. For example, the Guangyuanbao debris flow which occurred on July 04, 2013, partly blocked the Nanya River, presenting a major threat to the national highway and residential areas. To analyze the pattern of landslide damming, we analyzed numerical simulations of the movement characteristics of the Guangyuanbao debris flow using rainfall intensities with varying recurrence periods of 5, 20, and 50 years. The accuracy of the spreading of the numerical simulation is about 90%. The simulation indicated a small volume of sediment entering the river for a rainfall under 5-year return period. A debris flow induced by rainfall under 20-year return period partly blocked the river, while rainfall under 50-year return period has potential to block the river completely. This proposed analysis of river blocking induced by a debris flow could be used for disaster prevention in earthquake-stricken area.
Distributed Constrained Stochastic Subgradient Algorithms Based on Random Projection and Asynchronous Broadcast over Networks
Authors: Zhu Junlong , Xie Ping , Wu Qingtao , Zhang Mingchuan , Zheng Ruijuan , Guan Jianfeng , Xu Changqiao
Published: September 2017

We consider a distributed constrained optimization problem over a time‐varying network, where each agent only knows its own cost functions and its constraint set. However, the local constraint set may not be known in advance or consists of huge number of components in some applications. To deal with such cases, we propose a distributed stochastic subgradient algorithm over time‐varying networks, where the estimate of each agent projects onto its constraint set by using random projection technique and the implement of information exchange between agents by employing asynchronous broadcast communication protocol. We show that our proposed algorithm is convergent with probability 1 by choosing suitable learning rate. For constant learning rate, we obtain an error bound, which is defined as the expected distance between the estimates of agent and the optimal solution. We also establish an asymptotic upper bound between the global objective function value at the average of the estimates and the optimal value.
Comparison of Three Different Parallel Computation Methods for a Two‐Dimensional Dam‐Break Model
Authors: Zhang Shanghong , Li Wenda , Jing Zhu , Yi Yujun , Zhao Yong
Published: September 2017

Three parallel methods (OpenMP, MPI, and OpenACC) are evaluated for the computation of a two‐dimensional dam‐break model using the explicit finite volume method. A dam‐break event in the Pangtoupao flood storage area in China is selected as a case study to demonstrate the key technologies for implementing parallel computation. The subsequent acceleration of the methods is also evaluated. The simulation results show that the OpenMP and MPI parallel methods achieve a speedup factor of 9.8× and 5.1×, respectively, on a 32‐core computer, whereas the OpenACC parallel method achieves a speedup factor of 20.7× on NVIDIA Tesla K20c graphics card. The results show that if the memory required by the dam‐break simulation does not exceed the memory capacity of a single computer, the OpenMP parallel method is a good choice. Moreover, if GPU acceleration is used, the acceleration of the OpenACC parallel method is the best. Finally, the MPI parallel method is suitable for a model that requires little data exchange and large‐scale calculation. This study compares the efficiency and methodology of accelerating algorithms for a dam‐break model and can also be used as a reference for selecting the best acceleration method for a similar hydrodynamic model.
miRNA-Disease Association Prediction with Collaborative Matrix Factorization
Authors: Shen Zhen , Zhang You-Hua , Han Kyungsook , Nandi Asoke K. , Honig Barry , Huang De-Shuang
Published: September 2017

As one of the factors in the noncoding RNA family, microRNAs (miRNAs) are involved in the development and progression of various complex diseases. Experimental identification of miRNA-disease association is expensive and time-consuming. Therefore, it is necessary to design efficient algorithms to identify novel miRNA-disease association. In this paper, we developed the computational method of Collaborative Matrix Factorization for miRNA-Disease Association prediction (CMFMDA) to identify potential miRNA-disease associations by integrating miRNA functional similarity, disease semantic similarity, and experimentally verified miRNA-disease associations. Experiments verified that CMFMDA achieves intended purpose and application values with its short consuming-time and high prediction accuracy. In addition, we used CMFMDA on Esophageal Neoplasms and Kidney Neoplasms to reveal their potential related miRNAs. As a result, 84% and 82% of top 50 predicted miRNA-disease pairs for these two diseases were confirmed by experiment. Not only this, but also CMFMDA could be applied to new diseases and new miRNAs without any known associations, which overcome the defects of many previous computational methods.
CP-ABE Access Control Scheme for Sensitive Data Set Constraint with Hidden Access Policy and Constraint Policy
Authors: Helil Nurmamat , Rahman Kaysar
Published: September 2017

CP-ABE (Ciphertext-Policy Attribute-Based Encryption) with hidden access control policy enables data owners to share their encrypted data using cloud storage with authorized users while keeping the access control policies blinded. However, a mechanism to prevent users from achieving successive access to a data owner’s certain number of data objects, which present a conflict of interest or whose combination thereof is sensitive, has yet to be studied. In this paper, we analyze the underlying relations among these particular data objects, introduce the concept of the sensitive data set constraint, and propose a CP-ABE access control scheme with hidden attributes for the sensitive data set constraint. This scheme incorporates extensible, partially hidden constraint policy. In our scheme, due to the separation of duty principle, the duties of enforcing the access control policy and the constraint policy are divided into two independent entities to enhance security. The hidden constraint policy provides flexibility in that the data owner can partially change the sensitive data set constraint structure after the system has been set up.
Anisotropic Scattering Characteristics of a Radially Multilayered Gyrotropic Sphere
Authors: Cao Lei , Chen Yongpin , Kang Kai
Published: September 2017

We present a new closed-form solution to the scattering of a monochromatic plane wave by a radially multilayered gyrotropic sphere using the T-matrix method. This approach can be utilized to investigate the interactions of a plane wave and a gyrotropic spherical scatterer of multiple layers with each layer characterized by both permittivity and permeability tensors. Based on the completeness and noncoplanar properties of vector spherical wave functions (VSWFs), analytical expressions of the electromagnetic fields in each gyrotropic layer are first derived. The boundary conditions are then applied on each discontinuous interface to obtain the scattering coefficients. Validations are made by first comparing the radar cross section (RCS) values of a 2-layered gyrotropic sphere with that computed from the full-wave finite element method (FEM) simulation and then reducing the general case to uniaxial case to compare the RCS values with the published results computed by Fourier transform combined with VSWFs method; in both cases good agreements are observed. Several specific cases are fully explored to investigate how the RCS are influenced by the parameters of the multilayered spherical structure. The results show that when both electric and magnetic gyrotropy tensors are considered, the RCS of the multilayered spherical scatterer can be suppressed or enhanced, depending on proper configurations of the material parameters.
Sequential Parameter Identification of Fractional‐Order Duffing System Based on Differential Evolution Algorithm
Authors: Lai Li , Ji Yuan-Dong , Zhong Su-Chuan , Zhang Lu
Published: September 2017

Using the dynamic properties of fractional‐order Duffing system, a sequential parameter identification method based on differential evolution optimization algorithm is proposed for the fractional‐order Duffing system. Due to the step by step parameter identification method, the dimension of parameter identification of each step is greatly reduced and the search capability of the differential evolution algorithm has been greatly improved. The simulation results show that the proposed method has higher convergence reliability and accuracy of identification and also has high robustness in the presence of measurement noise.
Iterative Schemes to Solve Low-Dimensional Calibration Equations in Parallel MR Image Reconstruction with GRAPPA
Authors: Inam Omair , Qureshi Mahmood , Malik Shahzad A. , Omer Hammad
Published: September 2017

GRAPPA (Generalized Autocalibrating Partially Parallel Acquisition) is a widely used parallel MRI reconstruction technique. The processing of data from multichannel receiver coils may increase the storage and computational requirements of GRAPPA reconstruction. Random projection on GRAPPA (RP-GRAPPA) uses random projection (RP) method to overcome the computational overheads of solving large linear equations in the calibration phase of GRAPPA, saving reconstruction time. However, RP-GRAPPA compromises the reconstruction accuracy in case of large reductions in the dimensions of calibration equations. In this paper, we present the implementation of GRAPPA reconstruction method using potential iterative solvers to estimate the reconstruction coefficients from the randomly projected calibration equations. Experimental results show that the proposed methods withstand the reconstruction accuracy (visually and quantitatively) against large reductions in the dimension of linear equations, when compared with RP-GRAPPA reconstruction. Particularly, the proposed method using conjugate gradient for least squares (CGLS) demonstrates more savings in the computational time of GRAPPA, without significant loss in the reconstruction accuracy, when compared with RP-GRAPPA. It is also demonstrated that the proposed method using CGLS complements the channel compression method for reducing the computational complexities associated with higher channel count, thereby resulting in additional memory savings and speedup.
Simulating Land Use Change in the Seoul Metropolitan Area after Greenbelt Elimination Using the SLEUTH Model
Authors: Park Soyoung , Clarke Keith C. , Choi Chuluong , Kim Jinsoo
Published: September 2017

The aim of this study was to analyze the effect of a policy aimed at the removal of a greenbelt on future urban growth. The SLEUTH model was applied to the Seoul Metropolitan Area, South Korea, to predict urban growth under three different greenbelt removal scenarios. The accuracy of the model was verified using historical data with ROC and Kappa statistics of 82.6 and 76.3%, indicating reasonable accuracy. In the scenarios, suburban development grew in proportion to the degree of reduction of the greenbelt. In two of the scenarios, suburban cities in the inner part of the greenbelt were integrated into the metropolitan area. In scenario 3, a complete removal of the greenbelt resulted in the highest rate of projected urban development. The Seoul Metropolitan Area is under continuous developmental pressure, and the sacrifice of a certain amount of protected land to satisfy this demand may be inevitable. Accordingly, effective urban growth management is necessary to promote ecofriendly and sustainable development in formerly protected areas and to strengthen protection in the areas that will remain protected. The model outputs will be used by the government and policy makers to devise a more flexible and sustainable urban growth management policy.
Imaged‐Based Visual Servo Control for a VTOL Aircraft
Authors: Zou Liying , Li Huiguang , Zhao Wei , Zhu Lei
Published: September 2017

This paper presents a novel control strategy to force a vertical take‐off and landing (VTOL) aircraft to accomplish the pinpoint landing task. The control development is based on the image‐based visual servoing method and the back‐stepping technique; its design differs from the existing methods because the controller maps the image errors onto the actuator space via a visual model which does not contain the depth information of the feature point. The novelty of the proposed method is to extend the image‐based visual servoing technique to the VTOL aircraft control. In addition, the Lyapunov theory is used to prove the asymptotic stability of the VTOL aircraft visual servoing system, while the image error can converge to zero. Furthermore, simulations have been also conducted to demonstrate the performances of the proposed method.
Salidroside Protects against MPP+‐Induced Neuronal Injury through DJ‐1‐Nrf2 Antioxidant Pathway
Authors: Wu Leitao , Xu Hang , Cao Liang , Li Tao , Li Ruru , Feng Yang , Chen Jianzong , Ma Jing
Published: September 2017

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. We have found that salidroside (Sal) exhibited neuroprotective effects against MPP+ toxicity. However, the molecular mechanism is not fully understood. In this study, we found that Sal significantly prevented MPP+‐induced decrease of mRNA and protein expression of Nrf2, GCLc, SOD1, and SOD2 in SH‐SY5Y cells. Moreover, silencing of Nrf2 significantly inhibited Sal‐induced increase in mRNA and protein expression of GCLc, SOD1, and SOD2. But Nrf2 silence did not significantly impact Sal‐exhibited effects on DJ‐1 expression. Silencing of Nrf2 significantly suppressed the decrease of apoptosis induced by Sal in MPP+‐treated SH‐SY5Y cells. Sal significantly prevented MPP+‐induced decrease of the mRNA and protein expression of DJ‐1 in SH‐SY5Y cells. Moreover, silencing of DJ‐1 significantly inhibited Sal‐induced increase in mRNA and protein expression of Nrf2, GCLc, SOD1, and SOD2 in MPP+‐treated SH‐SY5Y cells. These results indicated that DJ‐1 was an upstream regulator of Nrf2 in the neuroprotective effects of Sal. Furthermore, silencing of DJ‐1 significantly suppressed the decrease of apoptosis induced by Sal in MPP+‐treated SH‐SY5Y cells. In conclusion, Sal prevented MPP+‐induced neurotoxicity through upregulation of DJ‐1‐Nrf2‐antioxidant pathway. Our findings provide novel insights into the neuroprotective effects of Sal against PD.
Respiratory Epithelium Lined Cyst of the Maxilla: Differential Diagnosis
Authors: Martinelli-Kläy C. P. , Chatelain S. , Salvado F. , Lombardi T.
Published: September 2017

Maxillary cysts, including the cysts lined by respiratory epithelium, can present a diagnostic challenge. We report an unusual case of a maxillary cyst on an endodontically treated tooth #16, in which the cavity was totally lined by a respiratory epithelium. The patient, a 35-year-old male, presented with a generalized chronic periodontitis and complained of a pain in the tooth #16 region. A periodontal pocket extending to the root apices with pus coming out from the gingival was found. A combined endodontic periodontal was observed on a panoramic radiography. CBCT-scan revealed a well-circumscribed radiolucent lesion at the apices of the distobuccal root of the 16. A communication with the right maxillary sinus cavity and a maxillary and ethmoidal sinusitis were also observed. The lesion was removed and histological examination revealed a cyst lined exclusively by respiratory epithelium. Ciliated and rare mucous cells were also observed. The diagnosis could evoke a surgical ciliated cyst mimicking the radicular cyst but the patient has no previous history of trauma or surgery in the maxillofacial region. It could also be an unusual radicular cyst in which the stratified squamous epithelium was destroyed by inflammation and replaced by a respiratory epithelium of the maxillary sinus.
Simulated Annealing Genetic Algorithm Based Schedule Risk Management of IT Outsourcing Project
Authors: Lu Fuqiang , Bi Hualing , Huang Min , Duan Shupeng
Published: September 2017

IT outsourcing is an effective way to enhance the core competitiveness for many enterprises. But the schedule risk of IT outsourcing project may cause enormous economic loss to enterprise. In this paper, the Distributed Decision Making (DDM) theory and the principal‐agent theory are used to build a model for schedule risk management of IT outsourcing project. In addition, a hybrid algorithm combining simulated annealing (SA) and genetic algorithm (GA) is designed, namely, simulated annealing genetic algorithm (SAGA). The effect of the proposed model on the schedule risk management problem is analyzed in the simulation experiment. Meanwhile, the simulation results of the three algorithms GA, SA, and SAGA show that SAGA is the most superior one to the other two algorithms in terms of stability and convergence. Consequently, this paper provides the scientific quantitative proposal for the decision maker who needs to manage the schedule risk of IT outsourcing project.
Nonlinear Research and Efficient Parameter Identification of Magic Formula Tire Model
Authors: Cheng Zhun , Lu Zhixiong
Published: September 2017

The Magic Formula tire model can describe the mechanical properties of tire accurately and thus is applied in the research field of vehicle dynamics widely. The Magic Formula tire model has the characteristics of a great number of parameters and the high nonlinearity, so it is hard to identify parameters. Researchers generally use different intelligent optimization algorithms for parameter identification. However, in the process of parameter identification, with a few experimental data, parameter identification results generally have the low accuracy, while, in the case of a large number of experimental data, the amount of work done in the experiment will increase and there will be many experimental errors. To solve these problems, this paper researches the longitudinal force of tire and proposes an interpolation method and a method based on the nonlinear research of the tire force. The results of parameter identification experiments on the two kinds of tire data show that both of the two methods can be used for the parameter identification of Magic Formula tire model fast and accurately with only a few experimental data. In addition, this paper proposes a method estimating the maximum longitudinal force and corresponding slip rate.
Evaluation of the Impact of Argo Data on Ocean Reanalysis in the Pacific Region
Authors: Zhang Xuefeng , Sun Chaohui , Liu Chang , Zhang Lianxin , Shao Caixia , Zhang Xiaoshuang , Zhao Yuxin
Published: September 2017

Observing System Simulation Experiments (OSSEs) have been conducted to evaluate the effect of Argo data assimilation on ocean reanalysis in the Pacific region. The “truth” is obtained from a 5-year model integration from 2003 to 2007 based on the MIT general circulation model with the truly varying atmospheric forcing. The “observations” are the projections of the truth onto the observational network including ocean station data, CTD, and various BTs and Argo, by adding white noise to simulate observational errors. The data assimilation method employed is a sequential three-dimensional variational (3D-Var) scheme within a multigrid framework. Results show the interannual variability of temperature, salinity, and current fields can be reconstructed fairly well. The spread of temperature anomalies in the tropical Pacific region is also able to be reflected accurately when Argo data is assimilated, which may provide a reliable initial field for the forecast of temperature and currents for the subsurface in the tropical Pacific region. The adjustment of salinity by using T-S relationship is vital in the tropical Pacific region. However, the adjustment of salinity is almost meaningless in the northwest Pacific if Argo data is included during the reanalysis.
Unchained Cellular Obfuscation Areas for Location Privacy in Continuous Location-Based Service Queries
Authors: Luo Jia-Ning , Yang Ming-Hour
Published: September 2017

To access location-based service (LBS) and query surrounding points of interest (POIs), smartphone users typically use built-in positioning functions of their phones when traveling at unfamiliar places. However, when a query is submitted, personal information may be leaked when they provide their real location. Current LBS privacy protection schemes fail to simultaneously consider real map conditions and continuous querying, and they cannot guarantee privacy protection when the obfuscation algorithm is known. To provide users with secure and effective LBSs, we developed an unchained regional privacy protection method that combines query logs and chained cellular obfuscation areas. It adopts a multiuser anonymizer architecture to prevent attackers from predicting user travel routes by using background information derived from maps (e.g., traffic speed limits). The proposed scheme is completely transparent to users when performing continuous location-based queries, and it combines the method with actual road maps to generate unchained obfuscation areas that conceal the actual locations of users. In addition to using a caching approach to enhance performance, the proposed scheme also considers popular tourist POIs to enhance the cache data hit ratio and query performance.
Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer
Authors: Carlomagno Nicola , Incollingo Paola , Tammaro Vincenzo , Peluso Gaia , Rupealta Niccolò , Chiacchio Gaetano , Sandoval Sotelo Maria Laura , Minieri Gianluca , Pisani Antonio , Riccio Eleonora , Sabbatini Massimo , Bracale Umberto Marcello , Calogero Armando , Dodaro Concetta Anna , Santangelo Michele
Published: September 2017

Introduction. Gastric cancer is the fifth most common cancer and the third cause of cancer death. The clinical outcomes of the patients are still not encouraging with a low rate of 5 years’ survival. Often the disease is diagnosed at advanced stages and this obviously negatively affects patients outcomes. A deep understanding of molecular basis of gastric cancer can lead to the identification of diagnostic, predictive, prognostic, and therapeutic biomarkers. Main Body. This paper aims to give a global view on the molecular classification and mechanisms involved in the development of the tumour and on the biomarkers for gastric cancer. We discuss the role of E-cadherin, HER2, fibroblast growth factor receptor (FGFR), MET, human epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (HGFR), mammalian target of rapamycin (mTOR), microsatellite instability (MSI), PD-L1, and TP53. We have also considered in this manuscript new emerging biomarkers as matrix metalloproteases (MMPs), microRNAs, and long noncoding RNAs (lncRNAs). Conclusions. Identifying and validating diagnostic, prognostic, predictive, and therapeutic biomarkers will have a huge impact on patients outcomes as they will allow early detection of tumours and also guide the choice of a targeted therapy based on specific molecular features of the cancer.
Effects of Layering Milling Technology on Distribution of Green Wheat Main Physicochemical Parameters
Authors: Tian Shuang-Qi , Li Yong-Heng , Chen Zhi-Cheng , Qiao Yong-Feng
Published: September 2017

With layered milling flour technology, the efficiency of the nutrient distribution and hardness was demonstrated with the green and normal wheat separation milling. The results showed that the total content of amino acid in green wheat was 8.3%–13.0% higher compared to the common wheat. Comparing the main nutriments Se, Fe, and Ca between green wheat and common wheat, the results showed that different milling treatment methods are capable of separating the different wheat flour from endosperms, bran, and aleurone layers. Micro- and physicochemical characterization of different wheat flour and layers by means of microscopy techniques and images analysis provided relevant qualitative and quantitative information, which can be useful for the study of the microstructure of green and normal wheat products and also for its processing and utilization.
Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study
Authors: Kroese Sylvia J. , Abheiden Carolien N. H. , Blomjous Birgit S. , van Laar Jacob M. , Derksen Ronald W. H. M. , Bultink Irene E. M. , Voskuyl Alexandre E. , Lely A. Titia , de Boer Marjon A. , de Vries Johanna I. P. , Fritsch-Stork Ruth D. E.
Published: September 2017

Objective. To investigate disease activity around and during pregnancy and pregnancy outcome in women with systemic lupus erythematosus (SLE) considering antiphospholipid antibody status. Moreover, differences between first and consecutive pregnancies were examined.Methods. Pregnancies > 16 weeks gestation of SLE patients receiving joint care from rheumatologists and gynecologists in two tertiary centers in the Netherlands between 2000 and 2015 were included. Disease activity, flare rate, and pregnancy outcomes and complications were assessed.Results. Ninety-six women (84% Caucasian) with 144 pregnancies were included. The median SLE(P)DAI score was 2 before, during, and after pregnancy. Flare rates were 6.3%, 20.1%, and 15.3%, respectively. Severe hypertensive disorder of pregnancy, intrauterine fetal death, preterm birth, and small-for-gestational age infants occurred in 18.1%, 4.1%, 32.7%, and 14.8%, respectively. Complication rates were similar in the first and consecutive pregnancies. Half of the women did not experience any pregnancy complication whereas 42.7% developed a complication during all pregnancies. Mean number of pregnancies was 2.4 and live births 1.7.Conclusion. In this SLE population with low disease activity, pregnancy complications were present irrespective of antiphospholipid antibody status. Furthermore, there were no differences in complication rates between the first and consecutive pregnancies as seen in healthy mothers. This information is useful for patient counseling.
Sewage Sludge Amendment Combined with Green Manuring to a Coastal Mudflat Salt-Soil in Eastern China: Effects on Soil Physicochemical Properties and Maize Yield
Authors: Bai Yanchao , Zuo Wengang , Yan Yiyun , Gu Chuanhui , Guan Yongxiang , Mei Lijuan , Xue Weijie , Shan Yuhua , Feng Ke
Published: September 2017

Sewage sludge and green manure have become widely used organic amendments to croplands in many regions of the world. However, the amending effect of the combination of sewage sludge with green manuring in reclaimed coastal mudflat salt-soil has been unclear yet. This paper was one of earlier studies to investigate and evaluate the effects of sewage sludge amendment combined with green manuring on selected soil physicochemical properties of the mudflat soil in a rain-fed agroecosystem. The mudflat salt-soil was amended by one-time input of sewage sludge at the rates of 0, 30, 75, 150, and 300 t ha−1. After green manuring for three consecutive seasons, maize (Zea maysL.) was planted in 2013 and 2014. The results showed that SSA combined with green manuring decreased bulk density, pH, salinity, and exchangeable sodium percentage of the topsoil (0–20 cm soil layer) and increased aggregate stability, cation exchange capacity, and N and P concentration of the topsoil. As a result, the maize yield increased with the increase of SSA rates. Sewage sludge combined with green manuring can be applied in coastal mudflat salt-soil amendment, which provides an innovative way to create arable land resources and safe disposal of sewage sludge.
Dynamic Channel Slot Allocation Scheme and Performance Analysis of Cyclic Quorum Multichannel MAC Protocol
Authors: Hu Xing , Ma Linhua , Huang Shaocheng , Huang Tianyu , Liu Shiping
Published: September 2017

In high diversity node situation, multichannel MAC protocol can improve the frequency efficiency, owing to fewer collisions compared with single‐channel MAC protocol. And the performance of cyclic quorum‐based multichannel (CQM) MAC protocol is outstanding. Based on cyclic quorum system and channel slot allocation, it can avoid the bottleneck that others suffered from and can be easily realized with only one transceiver. To obtain the accurate performance of CQM MAC protocol, a Markov chain model, which combines the channel‐hopping strategy of CQM protocol and IEEE 802.11 distributed coordination function (DCF), is proposed. The results of numerical analysis show that the optimal performance of CQM protocol can be obtained in saturation bound situation. And then we obtain the saturation bound of CQM system by bird swarm algorithm. In addition, to improve the performance of CQM protocol in unsaturation situation, a dynamic channel slot allocation of CQM (DCQM) protocol is proposed, based on wavelet neural network. Finally, the performance of CQM protocol and DCQM protocol is simulated by Qualnet platform. And the simulation results show that the analytic and simulation results match very well; the DCQM performs better in unsaturation situation.
Low-Light Image Enhancement Based on Guided Image Filtering in Gradient Domain
Authors: Sun Xiankun , Liu Huijie , Wu Shiqian , Fang Zhijun , Li Chengfan , Yin Jingyuan
Published: September 2017

We propose a novel approach for low-light image enhancement. Based on illumination-reflection model, the guided image filter is employed to extract the illumination component of the underlying image. Afterwards, we obtain the reflection component and enhance it by nonlinear functions, sigmoid and gamma, respectively. We use the first-order edge-aware constraint in the gradient domain to achieve good edge preserving features of enhanced images and to eliminate halo artefact effectively. Moreover, the resulting images have high contrast and ample details due to the enhanced illumination and reflection component. We evaluate our method by operating on a large amount of low-light images, with comparison with other popular methods. The experimental results show that our approach outperforms the others in terms of visual perception and objective evaluation.
A Bayesian Approach to Control Loop Performance Diagnosis Incorporating Background Knowledge of Response Information
Authors: Zhou Sun , Wang Yiming
Published: September 2017

To isolate the problem source degrading the control loop performance, this work focuses on how to incorporate background knowledge into Bayesian inference. In an effort to reduce dependence on the amount of historical data available, we consider a general kind of background knowledge which appears in many applications. The knowledge, known as response information, is about what faults can possibly affect each of the monitors. We show how this knowledge can be translated to constraints on the underlying probability distributions and introduced in the Bayesian diagnosis. In this way, the dimensionality of the observation space is reduced and thus the diagnosis can be more reliable. Furthermore, for the judgments to be consistent, the set of posterior probabilities of each possible abnormality that are computed from different observation subspaces is synthesized to obtain the partially ordered posteriors. The eigenvalue formulation is used on the pairwise comparison matrix. The proposed approach is applied to a diagnosis problem on an oil sand solids handling system, where it is shown how the combination of background knowledge and data enhances the control performance diagnosis even when the abnormality data are sparse in the historical database.
Study on the Effect of Different Fe2O3/ZrO2Ratio on the Properties of Silicate Glass Fibers
Authors: Liu Jianxun , Yang Jianping , Huo Haibin , Lei Liang , Cui Ying , Wu Zhishen
Published: September 2017

A series of silicate glass fibers with different ratios of Fe2O3/ZrO2were prepared, and their corrosion resistance, mass loss, and strength loss were characterized. The crystallization and melting properties of the fibers were analyzed by differential scanning calorimetry (DSC), high temperature viscometer, and high temperature microscope. The results show that the deformation temperature, sphere temperature, hemisphere temperature, and crystallization temperature of the fiber initially decrease and then increase with the increase of Fe2O3/ZrO2ratio, while the molding temperature decreases with the increase of the ratio of Fe2O3/ZrO2. When the ratio is close to 1 : 1, its alkali resistance is almost same as that of AR-glass fiber, and the drawing process performance is better. However, with the increase of the ratio, its alkali resistance continues to decline and the poor wire drawing performance is not conducive to the drawing operation.
Investigation and Analysis of the Simultaneous Switching Noise in Power Distribution Network with Multi-Power Supplies of High Speed CMOS Circuits
Authors: Ait Belaid Khaoula , Belahrach Hassan , Ayad Hassan
Published: September 2017

The paper studies a simultaneous switching noise (SSN) in a power distribution network (PDN) with dual supply voltages and two cores. This is achieved by reducing the admittance matrix Y of the PDN then calculating frequency domain impedance with rational function approximation using vector fitting. This paper presents a method of computing the simultaneous switching noise through a switching current, whose properties and details are described. Thus, the results are discussed and performed using MATLAB and PSpice tools. It demonstrated that the presence of many cores in the same PCB influences the SSN due to electromagnetic coupling.
Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers
Authors: Yau Edwin H. , Kummetha Indrasena Reddy , Lichinchi Gianluigi , Tang Rachel , Zhang Yunlin , Rana Tariq M.
Published: September 2017

Targeting mutant KRAS signaling pathways continues to attract attention as a therapeutic strategy for KRAS-driven tumors. In this study, we exploited the power of the CRISPR-Cas9 system to identify genes affecting the tumor xenograft growth of human mutant KRAS (KRASMUT) colorectal cancers. Using pooled lentiviral single-guide RNA libraries, we conducted a genome-wide loss-of-function genetic screen in an isogenic pair of human colorectal cancer cell lines harboring mutant or wild-type KRAS. The screen identified novel and established synthetic enhancers or synthetic lethals for KRASMUT colorectal cancer, including targetable metabolic genes. Notably, genetic disruption or pharmacologic inhibition of the metabolic enzymes NAD kinase or ketohexokinase was growth inhibitory in vivo. In addition, the chromatin remodeling protein INO80C was identified as a novel tumor suppressor in KRASMUT colorectal and pancreatic tumor xenografts. Our findings define a novel targetable set of therapeutic targets for KRASMUT tumors. Cancer Res; 77(22); 6330–9. ©2017 AACR.
Mutational Analysis of Gene Fusions Predicts Novel MHC Class I–Restricted T-Cell Epitopes and Immune Signatures in a Subset of Prostate Cancer
Authors: Kalina Jennifer L. , Neilson David S. , Lin Yen-Yi , Hamilton Phineas T. , Comber Alexandra P. , Loy Emma M.H. , Sahinalp S. Cenk , Collins Colin C. , Hach Faraz , Lum Julian J.
Published: September 2017

Purpose: Gene fusions are frequently found in prostate cancer and may result in the formation of unique chimeric amino acid sequences (CASQ) that span the breakpoint of two fused gene products. This study evaluated the potential for fusion-derived CASQs to be a source of tumor neoepitopes, and determined their relationship to patterns of immune signatures in prostate cancer patients.

Experimental Design: A computational strategy was used to identify CASQs and their corresponding predicted MHC class I epitopes using RNA-Seq data from The Cancer Genome Atlas of prostate tumors. In vitro peptide-specific T-cell expansion was performed to identify CASQ-reactive T cells. A multivariate analysis was used to relate patterns of in silico–predicted tumor-infiltrating immune cells with prostate tumors harboring these mutational events.

Results: Eighty-seven percent of tumors contained gene fusions with a mean of 12 per tumor. In total, 41% of fusion-positive tumors were found to encode CASQs. Within these tumors, 87% gave rise to predicted MHC class I–binding epitopes. This observation was more prominent when patients were stratified into low- and intermediate/high-risk categories. One of the identified CASQ from the recurrent TMPRSS2:ERG type VI fusion contained several high-affinity HLA-restricted epitopes. These peptides bound HLA-A*02:01 in vitro and were recognized by CD8+ T cells. Finally, the presence of fusions and CASQs were associated with expression of immune cell infiltration.

Conclusions: Mutanome analysis of gene fusion-derived CASQs can give rise to patient-specific predicted neoepitopes. Moreover, these fusions predicted patterns of immune cell infiltration within a subgroup of prostate cancer patients. Clin Cancer Res; 23(24); 7596–607. ©2017 AACR.
A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non–small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations
Authors: Yu Helena A. , Spira Alexander , Horn Leora , Weiss Jared , West Howard , Giaccone Giuseppe , Evans Tracey , Kelly Ronan J. , Desai Bhardwaj , Krivoshik Andrew , Moran Diarmuid , Poondru Srinivasu , Jie Fei , Aoyama Kouji , Keating Anne , Oxnard Geoffrey R.
Published: September 2017

Purpose: Acquired EGFR T790M mutations are the most frequently identified resistance mechanism to EGFR tyrosine kinase inhibitors (TKI) in patients with EGFR-mutant lung cancers. ASP8273 is a third-generation EGFR TKI with antitumor activity in preclinical models of EGFR-mutant lung cancer that targets mutant EGFR, including EGFR T790M.

Experimental Design: In this multicohort, phase I study (NCT02113813), escalating doses of ASP8273 (25–500 mg) were administered once daily to non–small cell lung cancer (NSCLC) patients with disease progression after prior treatment with an EGFR TKI. EGFR T790M was required for all cohorts, except the dose escalation cohort. Primary endpoints were safety/tolerability; secondary endpoints were determination of the RP2D, pharmacokinetic profile, and preliminary antitumor activity of ASP8273. Evaluation of the use of EGFR mutations in circulating free DNA (cfDNA) as a biomarker of ASP8273 treatment effects was an exploratory endpoint.

Results: A total of 110 patients were treated with ASP8273 across dose escalation (n = 36), response–expansion (n = 36), RP2D (300 mg; n = 19) and food–effect (n = 19) cohorts. The most common treatment-emergent adverse events included diarrhea, nausea, fatigue, constipation, vomiting, and hyponatremia. Across all doses, in patients with EGFR T790M, the response rate was 30.7% (n = 27/88; 95% CI, 19.5%–44.5%), and median progression-free survival was 6.8 months (95% CI, 5.5–10.1 months). EGFR mutations in cfDNA, both the activating mutation and EGFR T790M, became undetectable in most patients in the setting of clinical response and reemerged upon disease progression.

Conclusions: ASP8273 was well tolerated and promoted antitumor activity in patients with EGFR-mutant lung cancer with disease progression on prior EGFR TKI therapy. Clin Cancer Res; 23(24); 7467–73. ©2017 AACR.
Identification of MEK162 as a Radiosensitizer for the Treatment of Glioblastoma
Authors: Narayan Ravi S. , Gasol Ana , Slangen Paul L.G. , Cornelissen Fleur M.G. , Lagerweij Tonny , Veldman Hou Y.Y.E. , Dik Rogier , van den Berg Jaap , Slotman Ben J. , Würdinger Tom , Haas-Kogan Daphne A. , Stalpers Lukas J.A. , Baumert Brigitta G. , Westerman Bart A. , Theys Jan , Sminia Peter
Published: September 2017

Glioblastoma (GBM) is a highly aggressive and lethal brain cancer type. PI3K and MAPK inhibitors have been studied preclinically in GBM as monotherapy, but not in combination with radiotherapy, which is a key component of the current standard treatment of GBM. In our study, GBM cell lines and patient representative primary cultures were grown as multicellular spheroids. Spheroids were treated with a panel of small-molecule drugs including MK2206, RAD001, BEZ235, MLN0128, and MEK162, alone and in combination with irradiation. Following treatment, spheroid growth parameters (growth rate, volume reduction, and time to regrow), cell-cycle distribution and expression of key target proteins were evaluated. In vivo, the effect of irradiation (3 × 2 Gy) without or with MEK162 (50 mg/kg) was studied in orthotopic GBM8 brain tumor xenografts with endpoints tumor growth and animal survival. The MAPK-targeting agent MEK162 was found to enhance the effect of irradiation as demonstrated by growth inhibition of spheroids. MEK162 downregulated and dephosphorylated the cell-cycle checkpoint proteins CDK1/CDK2/WEE1 and DNA damage response proteins p-ATM/p-CHK2. When combined with radiation, this led to a prolonged DNA damage signal. In vivo data on tumor-bearing animals demonstrated a significantly reduced growth rate, increased growth delay, and prolonged survival time. In addition, RNA expression of responsive cell cultures correlated to mesenchymal stratification of patient expression data. In conclusion, the MAPK inhibitor MEK162 was identified as a radiosensitizer in GBM spheroids in vitro and in orthotopic GBM xenografts in vivo. The data are supportive for implementation of this targeted agent in an early-phase clinical study in GBM patients. Mol Cancer Ther; 17(2); 347–54. ©2017 AACR.

See all articles in this MCT Focus section, “Developmental Therapeutics in Radiation Oncology.”
Apresentação
Authors: Nascimento Aline Maia , Cruz Barbara Pimentel da Silva
Published: September 2017

Apresentação
"Usar o corpo": economias sexuais de mulheres jovens do litoral ao sertão no Nordeste brasileiro
Authors: Olivar José Miguel Nieto , Garcia Loreley
Published: September 2017

Neste artigo apresentamos um panorama organizado de diversas formas e sentidos da ideia de “usar o corpo” associada a transações entre sexo, afetos e dinheiro, que escapam do conceito de prostituição. O artigo surge de uma pesquisa realizada com mulheres jovens em contextos de prostituição nas cidades de Cabrobó (PE) e Mataraca (PB) no Nordeste brasileiro. As visões, conceitualizações e experiências dessas mulheres traduzem uma prolífera criação de categorias discursivas de diferenciação, articuladas a um jogo de moralidades com economias locais/regionais e noções de família. Mostraremos como essas “economias sexuais” são descritas pelas mulheres e como se desenha como um caminho possível para compreender, de uma perspectiva de gênero, as economias locais na sua interseção com o mundo do sexo, da reprodução, da conjugalidade e da vida familiar.
Historias de familia, historia de propriedad: dinámicas de parentesco en torno a un antiguo latifundio del Nordeste de Brasil
Authors: Figurelli Fernanda
Published: September 2017

El artículo se basa en un trabajo de campo realizado en una región antes ocupada por una gran propiedad ganadera y algodonera de Rio Grande do Norte, Brasil. Archivos públicos y antiguos dueños y empleados transmiten una historia sobre la propiedad en la cual se destaca la familia que poseía ese patrimonio. Así, a la hora de pensar la propiedad son fundamentales los lazos de parentesco recreados por sus dueños. A su vez, la dinámica de esos lazos gira en torno a la concentración de las tierras. De este modo, más que entidades delimitadas a priori, observamos una relación mutuamente constitutiva entre familia y propiedad que cuestiona los límites entre “esfera pública” y “esfera privada”. El artículo da cuenta de la familia como un proceso de producción permanente y procura mostrar las formas específicas que toma ese proceso, en el cual parentesco y concentración de tierras se muestran indisolubles.
As ilhas Trobriand, a antropologia e os Dimdim
Authors: Gontijo Fabiano
Published: September 2017

Os textos publicados pelos antropólogos – livros, artigos, diários – e as interpretações sobre essa produção criaram o que Annette B. Weiner chama de “lugares sagrados” da antropologia, como as Ilhas Trobriand. No entanto, pouco se escreveu sobre como os povos continuam suas vidas após a pesquisa de campo antropológica ou sobre o que pensam os povos sobre o trabalho de campo realizado em seu território, tornando esse lugar “sagrado”. Este artigo traz algumas reflexões sobre a relação entre o fazer antropológico, turismo e reflexividade elaboradas após uma visita realizada às Ilhas Trobriand em 2013.
Música, tradução e linguagem na diáspora do Santo Daime
Authors: Assis Glauber Loures de , Labate Beatriz Caiuby , Cavnar Clancy
Published: September 2017

Este artigo aborda a diáspora do Santo Daime através de sua dimensão musical. Para isso, são estabelecidos alguns paralelos com a expansão internacional da capoeira, do neopentecostalismo e das religiões afro-brasileiras, situando a transnacionalização do Santo Daime dentro do movimento mais amplo de diáspora das religiões brasileiras e do Sul Global. Segue-se daí uma discussão sobre o papel ritual da música e sobre os hinos religiosos daimistas, que são considerados como presentes sagrados e representam um importante pilar dos rituais. Os autores descrevem e refletem sobre como os hinos são cantados, traduzidos e interpretados em distintos países e contextos. Argumentam que são produzidos, por um lado, coesão e redes transnacionais e, por outro, ressignificações e conflitos. Essas discussões nos convidam ao debate sobre o uso ritual de psicoativos, a relação entre música e religião e sobre as noções de tradição, autenticidade e sagrado.
O grande jogo do casamento: um desafio antropológico e computacional em área de fronteira
Authors: Silva Marcio
Published: September 2017

Para Schneider, os estudos antropológicos de parentesco estão ancorados em uma Doutrina da Unidade Genealógica da Humanidade que teria distorcido a percepção etnográfica e consagrado um “non-subject”. Esta Doutrina pode ser assim resumida: em todas as culturas humanas, parentesco tem a ver com o reconhecimento de vínculos naturais entre os indivíduos, assim afiançando sua tradução universal em termos genealógicos. Este artigo se contrapõe à crítica de Schneider em duas frentes: indaga se necessariamente convém entender o método genealógico como um dispositivo de tradução; em outra, questiona se o método genealógico requer tal Doutrina para se definir. Paralelamente, a partir da pesquisa etnográfica concernente aos Enawene-Nawe, este artigo, nos horizontes da teoria da aliança, argumenta em favor da reabilitação do método genealógico que, neste século, não pode abrir mão de ferramentas computacionais. Isto, considerando que “a primeira tarefa da antropologia, pré-requisito de todas as outras, é entender e formular os símbolos e sentidos e suas configurações, de que uma cultura particular consiste” (ênfase no original, Schneider, 1984: 196).
Seres-terra e a expansão do político nos Andes peruano
Authors: Zuker Fábio
Published: September 2017

Seres-terra e a expansão do político nos Andes peruano