bluuebunny/crossref_metadata_2025 huggingface dataset:
Epigenetic Silencing of PTEN and Epi-transcriptional Silencing of MDM2 Underlied Resistance to Hypomethylating Agents in Myelodysplastic Syndrome
Authors: Lee Paul , Yim Rita Lok Hay , Miu Ka-Kai , Sin-Hang Fung , Liao Jinyue , Wang Zhangting , Li Jun , Yung Yammy , Chu Hiu-Tung , Yip Pui-Kwan , Lee Emily , Tse Eric , Kwong Yok-Lam , Gill Harinder
Published: January 2022

In myelodysplastic syndrome (MDS), resistance to hypomethylating agents (HMA) portends a poor prognosis, underscoring the importance of understanding the molecular mechanisms leading to HMA-resistance. In this study, P39 and Kasumi-1 cells and their azacitidine-resistant and decitabine-resistant sublines were evaluated comparatively with transcriptomic and methylomic analyses. Expression profiling and genome-wide methylation microarray showed downregulation of PTEN associated with DNA hypermethylation in P39 cell lines resistant to azacitidine and decitabine. This pattern of PTEN dysregulation was also confirmed in a cohort of patients failing treatment with HMA. DNA hypomethylation of MDM2 was detected with downregulation of MDM2 in HMA resistant cell lines. Long-read sequencing revealed significant RNA hypomethylation of MDM2 resulting in alternative splicing and production of a truncated MDM2 transcript in azacitidine-resistant P39 cells. The expression of this MDM2 truncated transcript was also significantly increased in HMA-resistant patients compared with HMA-responsive patients. In conclusion, epigenetic and epi-transcriptomic dysregulation of PTEN and MDM2 were associated with resistance to hypomethylating agents.
Talaromyces Marneffei Mp1p Antigen Detection May Play an Important Role in The Early Diagnosis of Talaromycosis in Patients with Acquired Immunodeficiency Syndrome
Authors: Chen Xiaoman , Ou Xu , Wang Haodi , Li Liya , Guo Pengle , Chen Xiejie , Cai Weiping , Tang Xiaoping , Li Linghua
Published: January 2022

Talaromycosis is a life-threatening fungal disease commonly seen in patients with acquired immunodeficiency syndrome (AIDS), which is endemic in Southern China and Southeast countries. The diagnostic methods available for talaromycosis are relatively time-consuming and yield a high mortality. Therefore, early diagnosis of talaromycosis is extremely important. We aimed to determine a potential method for assisting in its early diagnosis. A total of 283 patients with AIDS admitted to our hospital were prospectively included in this cross-sectional study and divided into those with Talaromyces marneffei (TSM group, n=93) and those without Talaromyces marneffei (non-TSM group, n=190). The diagnostic accuracy of the Mp1p enzyme immunoassay (EIA), galactomannan (GM) assay, and blood culture performed within 3 days of hospitalisation were evaluated, using talaromycosis confirmed by culture and/or pathology as the gold standard. The positivity rates in the Mp1p EIA, GM assay, and blood culture were 72%, 64.5%, and 81.7%, respectively, in the TSM group. The sensitivity, specificity, and positive and negative predictive values of the Mp1p EIA were 72.0% (67/93), 96.8% (184/190), 91.8% (67/73), and 87.6% (184/210), respectively. The Mp1p EIA showed a substantial agreement with the gold standard (kappa: 0.729) and superiority to the GM assay (kappa: 0.603); it also showed a superior diagnostic accuracy in the patients with CD4+ counts of <50 cells/µL compared to those with CD4+ counts ranged from 50–100 cells/µL. The Mp1p EIA has the advantage of assisting in the early diagnosis of talaromycosis in patients with AIDS, especially those with low CD4+ counts.
The 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase HSD-X1 of Pseudomonas
Citronellolis SJTE-3 Catalyzes the Conversion of 17β-estradiol to Estrone
Authors: Liang Rubing , Fu Yali , Peng Wanli , Lin Shuangjun , Deng Zixin
Published: January 2022

Background:

Pseudomonas citronellolis SJTE-3 can efficiently degrade 17β-estradiol
(E2) and other estrogenic chemicals. However, the enzyme responsible for E2 metabolism within
strain SJTE-3 has remained unidentified.

Objective:

Here, a novel 3-oxoacyl-(acyl-carrier protein) (ACP) reductase, HSD-X1 (WP_
009617962.1), was identified in SJTE-3 and its enzymatic characteristics for the transformation
of E2 were investigated.

Methods:

Multiple sequence alignment and homology modelling were used to predict the protein
structure of HSD-X1. The concentrations of different steroids in the culture of recombinant strains
expressing HSD-X1 were determined by high performance liquid chromatography. Additionally,
the transcription of hsd-x1 gene was investigated using reverse transcription and quantitative PCR
analysis. Heterologous expression and affinity purification were used to obtain recombinant HSD-
X1.

Results:

The transcription of hsd-x1 gene in P. citronellolis SJTE-3 was induced by E2. Multiple
sequence alignment (MSA) indicated that HSD-X1 contained the two consensus regions and
conserved residues of short-chain dehydrogenase/reductases (SDRs) and 17β-hydroxysteroid dehydrogenases
(17β-HSDs). Over-expression of hsd-x1 gene allowed the recombinant strain to degrade
E2. Recombinant HSD-X1 was purified with a yield of 22.15 mg/L and used NAD+ as its cofactor
to catalyze the oxidization of E2 into estrone (E1) while exhibiting a Km value of 0.025 ±
0.044 mM and a Vmax value of 4.92 ± 0.31 mM/min/mg. HSD-X1 could tolerate a wide range of
temperature and pH, while the presence of divalent ions exerted little influence on its activity. Further,
the transformation efficiency of E2 into E1 was over 98.03% across 15 min.

Conclusion:

Protein HSD-X1 efficiently catalyzed the oxidization of E2 and participated in estrogen
degradation by P. citronellolis SJTE-3.
Expression Profiles of Long Noncoding and Messenger RNAs in Epicardial
Adipose Tissue-Derived from Patients with Coronary Atherosclerosis
Authors: Du Yu , Zhu Yong , Liu Yan , Liu Jinxing , Hu Chengping , Sun Yan , Zhang Dai , Lv Sai , Cheng Yujing , Han Hongya , Zhang Jianwei , Zhao Yingxin , Zhou Yujie
Published: January 2022

Background:

Given its close anatomical location to the heart and its endocrine properties,
attention on epicardial adipose tissue (EAT) has increased.

Objective:

This study investigated the expression profiles of long noncoding RNAs (lncRNAs) and
messenger RNAs (mRNAs) in EAT derived from patients with coronary artery disease (CAD).

Methods:

EAT samples from 8 CAD, and 8 non-CAD patients were obtained during open-heart
surgery, respectively. The expression of lncRNAs and mRNAs in each EAT sample was investigated
using microarray analysis and further verified using reverse transcription-quantitative polymerase
chain reaction.

Results:

Overall, 1,093 differentially expressed mRNAs and 2,282 differentially expressed lncRNAs
were identified in EAT from CAD vs. non-CAD patients. Analysis using Gene Ontology and
the Kyoto Encyclopedia of Genes and Genomes showed that these differentially expressed genes
were mainly enriched in various inflammatory, immune, and metabolic processes. They were also
involved in osteoclast differentiation, B cell receptor and adipocytokine signaling, and insulin resistance
pathways. Additionally, lncRNA-mRNA and lncRNA-target pathway networks were built to
identify potential core genes (e.g., Lnc-CCDC68-2:1, AC010148.1, NONHSAT104810) involved
in atherosclerotic pathogenesis.

Conclusion:

In summary, lncRNA and mRNA profiles in EAT were markedly different between
CAD and non-CAD patients. Our study identifies several potential key genes and pathways that
may participate in atherosclerosis development.
Comparative Assessment of Polyherbal Formulation and Mucuna pruriens Extract as Neuroprotectant by Using MPTP Screening Mouse Model of
Parkinson’s Disease
Authors: Srivastava Amit Kishor , Naseer Arif , Gupta Amresh
Published: January 2022

Background:

The main aim of the study was to compare the neuroprotective potential
of Polyherbal Formulation (PHF) with that of an extract of a well-reported anti-parkinson plant,
i.e., Mucuna pruriens.

Methods:

Different PHF combinations (PHFs) were formulated by using hydro-alcoholic extracts
and were tested for neuroprotective potential against Mucuna pruriens extract (MPE). In the experimental
study, 30 albino mice (Swiss strain, 35-45g) were grouped into Control, MPTP, MPTP+
MPE, MPTP+PHFs, MPTP+ L-DOPA groups. Experimental mice were given PHFs and MPE
(50 mg/kg body wt.) by intraperitoneal routes. MPTP (1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine)
was given orally for 2 weeks with prior use of PHFs and MPE 20 mg/kg body wt. for 2
weeks. After treatment, a neurobehavioral study was performed as well as neurochemical parameters
were evaluated.

Results:

The results showed that polyherbal formulation improved the performance of the dopaminergic
neurons in the substantia nigra region of the brain compared to MPE with respect to MPTP intoxication.
A significant reduction was found in spontaneous locomotor activity and rotarod activity
in MPTP treated mice in contrast with the control group, in whom these activities were restored
by MPTP+MPE and MPTP+PHF1; however, this contrasted with the standard L-Dopa treatment
group. This improvement was observed to be significantly better in the MPTP+PHF1 treated group
compared to the treatment group of MPTP+MPE. The changes in different parameters occurred after
the MPTP treatment. These changes were observed in the levels of malondialdehyde (MDA),
conjugated dienes (CD), superoxide dismutase (SOD), and catalase.

Conclusion:

The study concluded that PHF treatment promotes significant neurogenesis, reduces
apoptosis, promotes antioxidant capacity, and restores dopamine levels. PHF contains numerous
classes of chemical constituents, which show a synergistic effect for better therapeutic remuneration
and neuroprotection compared to the single chemical entity L-DOPA, which is a well-known
chemical constituent present in MPE.
ADR Profile of the Covishield Vaccine Among Healthcare Workers in a
Tertiary Care Teaching Hospital in India
Authors: Deb Tirthankar , Garg Rajesh , Kaur Manmeet , Beniwal Ankita , Gupta Varsha
Published: January 2022

Background:

Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV). Though many classes of drugs have
been advocated/used for the treatment of this disease, vaccines are being targeted for its ultimate
prevention. Indian Government has approved Covishield (ChAdOx1 nCoV19 Corona Virus
Vaccine-Recombinant) for restricted use in emergency circumstances.

Objective:

This study is aimed at evaluating the safety profile of the Covishield vaccine among
healthcare workers in a tertiary care hospital.

Methods:

All Adverse Drug Reactions (ADRs) reported to the ADR monitoring centre by healthcare
workers who received the Covishield vaccine during the study period of 3 months were analysed
on various parameters, and the assessment was done using the WHO-UMC scale.

Results:

During the study period, a total of 1216 beneficiaries were vaccinated with 1st dose of Covishield,
and out of these, 727 beneficiaries also received 2nd dose of the vaccine. Out of the 1216
beneficiaries vaccinated, 69 ADRs were reported in 24 healthcare workers. The most common
ADR reported was fever (24.64%), followed by myalgia (18.84%). No death or any serious anaphylactic
reaction was observed. None of the healthcare workers experienced any adverse event during
the observation period of 30 minutes. Serious reactions were reported in 4 healthcare workers as
per the Pharmacovigilance Programme of India (PvPI) criteria of serious AEFI. 92% of healthcare
workers recovered from ADRs during the study period. 84% of ADRs were classified as probable
as per the WHO-UMC scale.

Conclusion:

As per the Government of India directives, all the healthcare workers in the institute
were encouraged to take both doses of the Covishield vaccine. The beneficiaries were kept under
observation for 30 minutes and monitored for any adverse drug reaction following vaccination. The
vaccine was found to be safe with a very low incidence of ADRs.
Влияние ориентации межфазной границы Ti-Al на скорость взаимной диффузии при твердом и жидком состояниях алюминия: молекулярно-динамическое моделирование
Authors: Полетаев Г.М. , Ракитин Р.Ю.
Published: January 2022

The influence of the orientation of Ti-Al interphase boundary on the intensity of mutual diffusion at solid-phase and solid-liquid-phase contacts was studied by the method of molecular dynamics. Four orientations of the boundary with respect to the Ti (hcp) and Al (fcc) lattices were considered: (0001):(111), (0001):(001), (101 ̅0):(111), (101 ̅1):(001). At solid-phase contact, an important phenomenon influencing the intensity of mutual diffusion was the formation, due to the mismatch of the lattices of Ti and Al, of grain boundaries in Al parallel to the interphase boundary. This boundary was both the main source and sink of structural defects, including vacancies required for diffusion to proceed. In the case of solid-liquid-phase contact, after melting of aluminium, part of it near the interphase boundary remained in the crystalline state, repeating the titanium lattice. That is, the boundary between the crystal and the liquid metal was shifted by two or three atomic planes deep into the aluminium. For the considered orientations, concentration curves were obtained after simulating mutual diffusion at different temperatures. The flatter parts of the curves, which are responsible for the diffusion of Ti atoms deep into liquid Al, turned out to be similar for all orientations. However, the parts related to the diffusion of Al atoms into crystalline Ti were different: diffusion of Al atoms in Ti proceeded more intensively with the orientation of the boundary (0001) and more slowly with the orientations (101 ̅0) and (101 ̅1).
Developing a Mobile Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events Administration System to Capture Postradiation Toxicity in Oncology: Usability and Feasibility Study
Authors: Underwood Jody , McCloskey Susan , Raldow Ann , Kishan Amar , Zalkin Chad , Navarro Daniel , Holt Lisa Scott , Webb Andrew , Lynch Kathleen A , Atkinson Thomas M
Published: January 2022

Background

Accurate self-reported symptomatic toxicity documentation via the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) is essential throughout cancer treatment to ensure safety and understand therapeutic efficacy. However, the capture of accurate toxicities from patients undergoing radiation therapy is challenging because this is generally provided only at the time of scheduled visits.

Objective

This study seeks to establish the usability and feasibility of a mobile PRO-CTCAE Administration System (mPROS) to capture toxicities related to radiation therapy.

Methods

English-speaking adult patients who were undergoing radiation therapy for cancer were enrolled and given a brief demonstration of the Say All Your Symptoms (SAYS) and Symptom Tracking Entry Program (STEP) interfaces of the mPROS app, followed by a patient-use phase where patient actions were observed as they navigated mPROS to enter toxicities. Patient feedback was captured via a semistructured interview and brief questionnaire.

Results

We enrolled 25 patients (age: mean 60.7 years; females: n=13, 52%; White patients: n=13; 52%; non-Hispanic patients: n=19, 76%; college graduates: n=17, 68%). Patients almost equally preferred the SAYS (n=14, 56%) or STEP (n=11, 44%) interfaces, with 21 patients (84%) agreeing that they would use mPROS to report their symptoms to their health care team and 19 patients (76%) agreeing that they would recommend mPROS to others.

Conclusions

The mPROS app is usable and feasible for facilitating the patient reporting of radiation therapy–related symptomatic toxicities. A revised version of mPROS that incorporates patient input and includes electronic health record integration is being developed and validated as part of a multicenter trial.
Metodología para Mejorar el Comisionamiento de Plantas Nuevas Integrando las Normas ISO 55000:2014 y ISO 14224:2016, Caso de Estudio
Authors: Correa-Correa Edwin Adrián , Franco-Cardona Carlos Jaime
Published: January 2022

El comisionamiento de plantas nuevas es una parte fundamental del proceso de producción energía, el objetivo de este artículo es presentar una metodología que permita Mejorar el Comisionamiento de las plantas eólicas y solares fotovoltaicas, para esto se tomaron las normas ISO 55000:2014 e ISO 14224:2016 y con esto se tiene como resultado una metodología de cuatro fases: Fase 1: Norma ISO 14224 Taxonomía. Fase 2: Norma ISO 31000 Criticidad. Fase 3: Metodología RCM (Reliability Centred Maintenance). Fase 4: Aportes de las fases a los requisitos de norma ISO 55001. Se concluye que al aplicar esta metodología se mejora el comisionamiento de las plantas eólicas y solares fotovoltaicas.
Extraction of Synovial Fluid from the Non-Effusive Pathologic Knee with Pneumatic Compression
Authors: MD Ahsan Iqbal, , MD Sumir Brahmbhatt, , MD Maheswari Muruganandam, , MD Jaren R. Trost, , MD Fatemeh Jafari Farshami, , MD David R. Cisneros, , MD Adnan N. Kiani, , MD Matthew K. McElwee, , PhD William A. Hayward, , PhD Luke J. Haseler, , PhD Philip A. Band, , MD Wilmer L. Sibbitt, Jr.,
Published: January 2022

Objectives –Aspiration of synovial fluid from non-effusive
joints is undertaken for the diagnosis of crystal-associated arthritis,
biomarker analysis, and to confirm intraarticular positioning. We
hypothesized that pneumatic compression of the non-effusive knee would
mobilize occult synovial fluid and improve arthrocentesis success.

Methods – The absence of a knee effusion was determined by
physical examination, imaging, and exclusion of confounding
disease.  Conventional arthrocentesis was performed in 111 consecutive
non-effusive knees and arthrocentesis volume (milliliters) determined.
Pneumatic compression was then applied, and arthrocentesis was resumed.

Results – Pneumatic compression improved fluid yield:
conventional: 0.4±1.0 ml, compression: 1.8±2.5 ml (319% increase, 95%
CI  -1.9<-1.4<-0.9; p=0.0001). Pneumatic compression
reduced arthrocentesis failure (< 0.1 ml) from 74.8% (83/111)
to 41.4% (46/111) (p=0.0001) and improved successful arthrocentesis in
terms of adequate synovial fluid yield: 1) ≥ 0.1 ml from 25.2% (28/111)
to 58.5% (65/111) (+132%, p=0.0001), 2) ≥ 0.5 ml from 22.5% (25/111)
to 57.7% (64/111) (+156%, p =0.0001), 3) ≥ 2.0 ml from 11.7% (13/111)
to 47.7% (53/111) (+300%, p =0.0001), and 4) ≥ 3.0 ml from 5.4%
(6/111) to 36.0% (40/111) (+319%, p =0.0001).

Conclusions: Pneumatic compression of the non-effusive knee
improves the extraction of synovial fluid of various requisite volumes
for conventional and biomarker analysis.
Possible toxicity of chronic carbon dioxide exposure associated with mask use, particularly in pregnant women, children and adolescents -a scoping review
Authors: Kisielinski Kai , Wagner Susanne , Hirsch Oliver , Klosterhalfen Bernd , Prescher Andreas
Published: January 2022

Literature was systematically reviewed regarding CO
exposure and facemask use. Observational and experimental data are
helpful for a risk-benefit assessment for masks as a popular
non-pharmaceutical intervention against SARS-CoV2 in the populace. Masks
impede breathing by increasing the resistance and dead space volume
leading to a re-breathing of CO with every breath
taken. Fresh air has around 0.04% CO, while wearing
masks more than 5 minutes bears a possible chronic exposure to carbon
dioxide of 1.41% to 3.2% of the inhaled air. Although the buildup is
usually within the short-term exposure limits, long-term consequences
must be considered due to experimental data. US Navy toxicity experts
set the exposure limits for submarines carrying female crews to 0.8%
CO based on animal studies indicating an increased risk
for stillbirths. Additionally, in mammals chronically exposed to 0.3%
CO experimental data demonstrates teratogenicity with
irreversible damage of neurons and reduced spatial learning caused by
brainstem neuron apoptosis and a reduced blood level of the insulin-like
growth factor 1. With significant impact on three readout parameters
(morphological, functional, marker) this chronic 0.3%
CO exposure has to be defined as being toxic.
Additional data exists on the exposure of chronic 0.3%
CO in adolescent mammals causing neuron destruction,
which includes less activity, increased anxiety and impaired learning
and memory. There is a possible negative impact risk by imposing
extended mask mandates especially for vulnerable subgroups.
Circumstantial evidence exists that extended mask use may be related to
current observations of stillbirths and to reduced verbal motor and
overall cognitive performance in children born during the pandemic.
Extended masking in pregnant women, children and adolescents has not
been thoroughly tested and studied. As a result of the animal
experimental data available, a risk-benefit analysis is urgent and a
need exists to rethink mask mandates, which provide appropriate
warnings.
COPE Flowcharts and infographics – How to recognise potential authorship problems
Authors: Editorial Article
Published: January 2022

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Persepsi Kemanfaatan dan Persepsi Kemudahan pada Minat Membayar PBB Menggunakan Go-Pay dengan Sikap Penggunaan sebagai Variabel Intervening
Authors: Wardani Dewi , Primastiwi Anita , Hermalia Hermalia
Published: January 2022

This study aims to examine whether the perceived usefulness and perceived convenience affect the interest in paying land and building tax using go-pay through the use attitude as an intervening variable. This research method uses quantitative description methods and primary data using a questionnaire. The study took a sample of 87 respondents who used go-pay and were taxpayers of land and building in Sleman Regency. The sampling technique using convenience sampling technique. Data were collected by leaving a questionnaire in the google form and questionnaire.The results of this study indicate that the perceived usefulness and perceived ease of use have a positive effect on the attitude of use. Perceptions of usefulness, perceived ease of use and attitudes of use have a positive effect on interest in paying land and building taxes using go-pay. perceived usefulness and perceived convenience have a positive effect on interest in paying land and building tax using go-pay through usage attitudes.
Meropenem-inducirovannoe snizhenie chuvstvitel'nosti k kolistinu u Pseudomonas aeruginosa ATCC 27853
Authors: Савинова Т. А. , Бочарова Ю. А. , Чаплин А. В. , Коростин Д. О. , Шамина О. В. , Маянский Н. А. , Чеботарь И. В.
Published: January 2022

Nechuvstvitel'nye k antibiotikam shtammy Pseudomonas aeruginosa predstavlyayut soboj global'nuyu problemu v zdravoohranenii. Issledovanie mekhanizmov vozniknoveniya rezistentnosti lezhit v osnove razrabotki sposobov bor'by s P. aeruginosa. Cel'yu raboty bylo issledovat' vozniknovenie kross-rezistentnosti u P. aeruginosa v processe adaptacii k populyarnomu antibiotiku meropenemu. Ob"ektami issledovaniya byli obrazcy P. aeruginosa, poluchennye pri roste referentnogo shtamma P. aeruginosa ATCC 27853 na srede s vozrastayushchej koncentraciej meropenema. CHuvstvitel'nost' izolyatov k karbapenemam i kolistinu opredelyali pri pomoshchi razvedeniya v agare, chuvstvitel'nost' k kolistinu ocenivali metodom serijnyh razvedenij. Bylo polucheno 93 izolyata P. aeruginosa, dva iz kotoryh imeli snizhennuyu chuvstvitel'nost' odnovremenno k karbapenemam (meropenem, imipenem) i kolistinu. Genomy izolyatov sekvenirovali na polnogenomnom sekvenatore MGISEQ-2000; obnaruzheny missens-mutacii v genah oprD i mexD i nonsens-mutaciya v phoQ. Poluchnnye rezul'taty pokazyvayut, chto pri vozdejstvii meropenema na shtammy P. aeruginosa mozhet razvivat'sya kross-rezistentnost' k kolistinu — preparatu rezerva dlya lecheniya sinegnojnoj infekcii.
Cirurgia plástica periodontal, pela técnica flapless, associada aos laminados cerâmicos para a correção do sorriso – relato de caso
Authors: Moretti Junior João , Oliani Louise Nadalini
Published: January 2022

The harmonious relationship between lip, teeth, and gum is the main goal to be achieved in aesthetic rehabilitation treatments. The presence of a gingival smile is one of the factors that most bother the individual. This case report demonstrates the performance of gingivectomy with flapless osteotomy in the anterior superior teeth, associated with ceramic laminates. Thanks to this approach, a satisfactory result of the gingival contours and dental formats was achieved in relation to the lip.
Kontrovesi Perang Malam Hari dan Ambivalensi Tokoh Karna dalam Lakon Suluhan
Authors: Lutfhi Muhammad
Published: January 2022

AbstractThis study aims to understand the meaning of Suluhan or the Death of Gatutkaca Play by Ki Hadi Sugito. This study employs qualitative descriptive method in which Paul Ricoeur's hermeneutic theory is used. Note-taking, listening, and identity techniques were used in data analysis. The results show that Adipati Karna’s decisions and actions to fight at night becomes the driving force of the events that occur in the next scenes. Adipati Karna's actions break the rules of war to disprove the accusation of being a spy and to prove his loyalty to the Kurawas. The death of Gathutkaca in Tegal Kurusetra is not solely due to the Adipati Karna’s or Kalabendana’s actions, but it has become Gathutkaca’s choice and destiny as it is written in the Jitabsara Book. AbstrakPenelitian ini bertujuan memahami makna Lakon Suluhan Ki Hadi Sugito. Penelitian ini menggunakan teori hermeneutika Paul Ricoeur. Metode deskriptif kualitatif digunakan dalam penelitian ini. Teknik catat, simak, dan padan orthografi digunakan dalam analisis data. Hasil penelitian menunjukkan bahwa keputusan dan tindakan adipati Karna berperang pada malam hari menjadi penggerak dari peristiwa-peristiwa yang terjadi dalam adegan-adegan berikutnya. Tindakan Adipati Karna melanggar aturan perang dalam rangka untuk menegasi tuduhan mata-mata terhadap dirinya dan untuk membuktikan kesetiaannya pada Kurawa. Kematian Gathutkaca di Tegal Kurusetra bukan semata-mata karena perbuatan Adipati Karna atau Kalabendana, namun sudah menjadi pilihannya dan dalam kerangka takdir Tuhan Yang Maha Kuasa seperti tertulis dalam Kitab Jitabsara.
Russia in the economic context of China, the USA, Germany, and India
Authors: SMIRNOV Valerii V.
Published: January 2022

Subject. The article addresses the economic cooperation of Russia with major countries.
Objectives. The aim is to identify conditions for the growth and development of the Russian economy in relations with China, the USA, Germany, and India.
Methods. The study draws on the systems approach, using the method of statistical, neural network and cluster analysis.
Results. The main condition for the growth of the Russian economy is the excess of direct investments from the USA, India and Germany over investments from China. Russia is dependent on China's external balance of goods and services. The rate of growth of Russia’s military expenditures is commensurate with Germany and India.
Conclusions. The identified conditions for the growth of the Russian economy enable the country’s leadership to formulate reasonable foreign economic policies.
Tiempo y teoría social. Hacia una clasificación operativa de las sociologías del tiempo
Authors: Torres Felipe
Published: January 2022

El presente trabajo cruza tres niveles desde los cuales se podría abordar la noción ‘tiempo’ en la teoría social. En primer lugar, una dimensión en sentido estricto, relativa a la localización nuclear del concepto al interior de ciertos análisis de la emergente sociedad contemporánea; en segundo lugar, se explora la aplicación diagonal que el concepto ‘tiempo’ posee en algunos lugares de la teoría sociológica, así como una dimensión relacionada con, tercero, la evaluación que esta categoría tiene en sentido normativo. A través de esta clasificación, se espera hacer mención a los programas teóricos más recientes y originales sobre la temporalidad social. Con esto se espera mostrar i) que el tiempo no resulta una categoría marginal al interior de la sociología; ii) que la clasificación propuesta permite organizar de manera esquemática las diferentes aproximaciones teóricas al tiempo desde los estudios sociales y culturales, y iii) que su estudio resulta de gran actualidad, especialmente en relación a las posibilidades descriptivas y límites críticos de los fenómenos temporales al interior de la teoría sociológica.

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This paper initially crosses three levels from which the notion of ‘time’ in sociology could be approached. Firstly, a dimension in the strict sense, related to the nuclear location of the concept within certain analyses of the emerging contemporary society; secondly, the diagonal application that the concept ‘time’ has in some places of sociological theory is explored, as well as a dimension related to, thirdly, the evaluation that this category has in a normative sense. Through this classification, it is hoped to make mention of the most recent and original theoretical programmes on social temporality. With this we hope to show i) that time is not a marginal category within sociology; ii) that the proposed classification allows us to organise in a schematic way the different theoretical approaches to time in sociology, and iii) that its study is highly topical, especially in relation to the descriptive possibilities and critical limits of temporal phenomena within sociological theory.
Sistem Agribisnis dan Rantai Persediaan Cabai di Pekanbaru
Authors: Ahmad Mukhtar , Febriska Febriska , Darus Darus
Published: January 2022

Untuk memahami hubungan sebab-akibat ketidakstabilan harga cabai di Pekanbaru; yang diperekirakan erat kaitannya dengan disebabkan dari segi system agribisnis dan rantai persediaan (supply chain) suatu penelitian survei denga metoda kualitatif dilakukan. Pada kenyataannya system agribisnis cabai belum terbentuk secara terpadu dan melembaga sehingga tidak ada bentuk pengendalian lonjakan harga yang telah berlangsung berpuluh tahun, yang sepenuhnya ditentukan pasar. Sumber persediaan cabai berasal dari Jawa Tengah, mengganti sumber persediaan dari Sumatera Barat. Bahkan juga pernah diimpor dari China, Malaysia dan Korea seperti pada tahun 2014. Pertumbuhan penduduk Pekanbaru yang pesat tidak mampu diimbangi oleh usaha tani cabai yang sebenanya semakin berkembang di Pekanbaru dalam tingkat yang agak lambat. Difahami secara garis besar hubungan sebab-akibatnya antara ketidakstabilan harga bahkan juga angka inflasi sesaat di Pekanbaru. Keadaan itu erat kaitannya dengan belum mantapnya system agribisnis, terutama kelembagaannya. Rantai persediaan (supply chain) cabai ternyata sudah berubah selaras dengan perubahan meningkatnya penduduk Pekanbaru. Pembentukan dan pengelolaan sistem agribisnis cabai dengan campur tangan pemerintah pada masa awal merupakan jalan keluar.
Azo or Not: Crystallographic Insights into β-Naphthol Reds
Authors: Heaney Matthew , Unruh Daniel , Runcevski Tomce
Published: January 2022

β-Naphthol reds are a group of widely used pigments with prominent historical, commercial, and cultural significance. In in-dustry, and especially within the art and heritage community, they are known as azo pigments. However, β-naphthols, very often, are not azo pigments. Due to enol/keto tautomerization of the 1-arylhydrazone-2-naphthol skeleton, these pigments oftentimes crystallize as hydrazones (keto). Therefore, proper characterization is necessary for understanding their intrinsic physicochemical properties and chemical reactivity in the solid state, as well as stability and lightfastness. Here, we focused on two representative β-naphthol reds, pigment red 40 (PR40) and pigment red 4 (PR4). Using single-crystal X-ray diffraction, we provide decisive proof that both of these pigments are keto/hydrazones in the solid state. Therefore, the frequent yet erroneous designation as azo pigments should be avoided. To confirm the bulk structure, we performed powder diffraction experiments, followed by Rietveld refinement. We complemented the diffraction experiments with spectroscopic (IR, Raman, UV-vis) and thermal (TGA, DSC) analyses. Furthermore, we studied the lightfastness of both chromophores in solution and solid state. While the solid state pigments were stable over the course of the experiment, UV irradiation of solutions resulted in degradation, which was studied by chromatographic and mass-spec techniques. We hope that this research will bring to light the necessity of proper solid-state characterization of β-naphthol reds, as well as pigments as a whole.
SOIL CONSERVATION PRACTICES IN FOREST OF NEPAL
Authors: Paudel Asmita , Bhattarai Asmita , Yadav Pankaj Kumar
Published: January 2022

Forests play a vital role in Nepalese rural communities, which rely on them for firewood, employment, additional meals, and good health to sustain and improve their lifestyles. It has contributed to the Nepalese farming system. Soil helps in regulating ecological processes like nutrient uptake, decomposition, and water availability in the forest. Nepal’s annual soil loss ranges from 2-105 t ha-1 with 34% water-induced erosion, 60% mass wasting (geological erosion), and 3 % by wind erosion. Forest soil requires various management and conservation practices to minimize the exploitation of forest lands. Hence, this article explains the ongoing soil conservation approaches like Afforestation, Agroforestry, and community forest management in Nepal. This article can also be the roadmap for the formulation of appropriate policies in soil conservation, and indirectly in maintaining sustainability in the ecology.
Оцінка структурних змін зайнятості на регіональних ринках праці
Authors: Руденко Наталя Валентинівна , Лісогор Лариса Сергіївна
Published: January 2022

Проблеми структурних зрушень у сфері зайнятості регіонів в умовах інноваційних змін потребують детального дослідження та набувають особливої актуальності, оскільки саме підвищення освітнього рівня населення регіонів забезпечує можливості реалізації їх освітнього потенціалу. Дослідження структурних змін зайнятості населення регіонів (за рівнями освіти) дало змогу визначити напрями адаптації сфери зайнятості до інноваційних змін. Оцінювання інтенсивності структурних змін зайнятості населення регіонів (за рівнями освіти) свідчить про збереження високих коефіцієнтів «абсолютних» структурних зрушень у регіонах зі значною часткою висококваліфікованих працівників у структурі зайнятих. Визначено причини збереження невисоких темпів структурних зрушень зайнятості працівників з вищою освітою в окремих регіонах, зокрема, посилення міграційних відтоків робочої сили з праценадлишкових регіонів, обмежені можливості працевлаштування за професією, з належним рівнем оплати праці. Обґрунтовано, що регіони, в яких коефіцієнти «абсолютних» структурних зрушень зайнятості працівників з вищою освітою перевищують середній рівень, більш привабливі з позицій можливостей їх працевлаштування та забезпечення професійного розвитку у перспективі. Здійснене групування регіонів за розподілом коефіцієнтів «абсолютних» структурних зрушень серед зайнятого населення з вищою освітою дало змогу визначити інтенсивність змін залежно від рівня економічного розвитку регіону, розвиненості освітньої мережі та інноваційної інфраструктури. З метою забезпечення можливостей реалізації освітнього потенціалу регіонів за рахунок підвищення освітнього рівня населення запропоновано залучати роботодавців до розробки освітніх програм; розвивати систему дуальної освіти. Також обґрунтовано необхідність сприяння розвитку неформальної освіти, що підвищуватиме рівень конкурентоспроможності робочої сили; створення умов для розбудови системи підтвердження результатів неформальної освіти за рахунок розширення мережі кваліфікаційних центрів. Розвиток системи освіти та професійної підготовки на регіональному рівні потребує запровадження моніторингу розвитку регіональних ринків праці та збалансування попиту й пропозиції на ринку праці (за рівнями освіти).
У пошуках ключа успіху України на світових ринках
Authors: Вірченко Оксана Олександрівна , Романчук Катерина Василівна , Шиманська Катерина Володимирівна
Published: January 2022

Проаналізовано позиції України серед країн ЄС за показником готовності до майбутнього виробництва (за складовими: складність та структура виробництва, та драйверами: людський капітал та ресурси сталого розвитку) для визначення потенційної конкурентоспроможності України у процесі інтеграції у таке об’єднання та окреслення можливих шляхів її підвищення. У дослідженні використано загальнонаукові методи пізнання, зокрема, систематизацію, порівняння, аналіз та синтез. У процесі дослідження проаналізовано окремі компоненти інтегральної оцінки готовності України до виробництва майбутнього в компаративному аспекті (за складовими: складність та структура виробництва, та драйверами: людський капітал та ресурси сталого розвитку); визначено питання, які потребують першочергового вирішення з метою нарощення конкурентних переваг України на світових ринках і спроможності протистояти ризикам та викликам майбутнього; окреслено напрями подальших досліджень. Теоретичне значення дослідження полягає у розвитку (прирості) наукового знання щодо факторів, за якими оцінюється готовність країни протистояти ризикам і викликам майбутнього у глобалізованому світі та їх впливу на формування конкурентоспроможності України. Практичне значення отриманих у дослідженні результатів полягає у можливості використання урядом України, науковою спільнотою та неурядовими організаціями ідентифікованих у дослідженні проблемних точок, за якими існують розриви для розробки стратегії та заходів її реалізації, яка дасть можливість активізути їх відповідно до значень, рівних або наближених до значень країн-членів ЄС. Наукова новизна дослідження полягає у розвитку підходу щодо ідентифікації конкурентних переваг України на світових ринках через компаративний аналіз вибраних показників з країнами ЄС з огляду на готовність протистояти ризикам та викликам майбутнього.
STAY-HEALTHY: AN EXPERT SYSTEM TO SUGGEST A HEALTHY DIET
Authors: Roy Febin , Shaji Ashish , Sherimon Vinu , Salim Al Amri Malak Majid
Published: January 2022

In this time of sudden outbreaks of illnesses and new viruses, people try to seek out more healthy and better lives to protect their fitness in all viable ways. As ways as an amateur character care, he/she isn't aware of the shape of ingredients and therefore the big variety of energy to eat which could lead on him/her to a healthful life, especially people that are suffering from persistent non-Communicable illnesses (NCD) which include cardiovascular illnesses, hypertension, diabetes etc. This study proposes the development of a knowledgeable gadget that shows a customized everyday weight loss program plan, specifically for citizens suffering from NCD. As a part of this study, we've developed a recommendation system considering the above facts. Recommendation systems are considered an efficient technology that helps users to regulate their healthy diet and be free from the NCDs.
Educación filosófica y ciudadanía: La vocación política de los estudios generales
Authors: Campà Molist Joan Enric
Published: January 2022

Si bien es cierto que no existen las democracias perfectas, sí podemos afirmar que existen las democracias más o menos democratizadas. Sin embargo, queda por descubrir el modo de democratizar las democracias. En este artículo, apoyados en un análisis comparativo entre el concepto ciudadanía y educación filosófica (o educación en filosofía), se plantean dos hipótesis relativas al carácter democratizador de la educación y al papel que deben cumplir los Estudios Generales desde su dimensión política. Como conclusión, y respaldado por autores como Robert Alan Dahl y Carlos S. Nino, especialmente, se expondrá el lazo transdisciplinar que aúna la educación filosófica, el estatus de ciudadanía, los índices de desarrollo humano y justicia social.
The Influence of Economic Pressures and Gender Roles to Family Resilience During Covid-19 Pandemic
Authors: Sukmawati Indah , Puspitawati Herien
Published: January 2022

The existence of Covid-19 has changed the socio-economic life of the community. This study aims to analyze the effect of family characteristics, economic pressure, and gender roles on family resilience during the Covid-19 pandemic. Respondents in this study were wives from intact families with children scattered in Bogor Regency. The design of this research is a cross-sectional study with a sampling technique using purposive sampling method with a total sample of 84 families conducted in March 2021. The data processing uses descriptive tests, correlation test, and multiple linear regression tests. The results of the study found that most of the family's economic pressure and gender roles were in the low category. However, most of the family resilience is in the high category. The results of multiple linear regression analysis show that there is a significant negative effect of economic pressure on family resilience. There is a significant positive effect of gender roles on husband's income.
Metabolic Syndrome
Authors: Shafeeq Noorhan Khalid , Hussein Tamara Ala'a , Abass Eiman AA.
Published: January 2022

Metabolic syndrome (MetS) is a combination of health disorders that mainly result from overweight and obesity. It increases the risk of developing cardiovascular disease and diabetes. (MetS) closely related to the existence weight gain or Obesity and laziness. It increases the serum levels of TNF-Î± and change the levels of a number of other parameters (e.g., adiponectin, resistin, and PAI-1). TNF-Î± dose not only appear to cause the production of inflammatory cytokines. It can trigger cell signaling by interacting with TNF-Î± receptors that can lead to insulin resistance. Usually, the digestive system molders the foods you eat and converts them to glucose. Insulin is an anabolic hormone produced by the pancreas that aids glucose get in your cells. To be utilize, as an energy source .Cells do not respond to insulin normally, and sugar cannot easily enter cells in people with insulin resistance. As outcome, blood glucose rises, until the body produces more insulin in an attempt to lower blood sugar. The following factors increase the chance of developing MetS as age increases the risk of developing MetS with age and ethnicity. In the United States, it appears that women of Mexican descent are more likely to develop MetS. Obesity carrying an extra amount of weight, especially in the abdomen, increases the risk of MetS. From this review, it stated that metabolic syndrome stands for the constellation of cardiovascular risk factors that raise the risk of cardiovascular arteriosclerosis and type 2 diabetes. Type 2 diabetes is a major global public health issue with more than 300 million people projected in 2025.
Практикум по программе дополнительной профессиональной переподготовки по экспертной специальности 5.1 «Идентификация человека по фотоснимкам и видеоизображениям». Учебное пособие для экспертов
Authors: Зинин А. , Воронцова В. , Ильин Н. , Косыгин О. , Михалева Н. , Бормотова Я.
Published: January 2022

В пособии раскрыты научные и методические основы судебной портретной экспертизы, даны рекомендации, которых следует придерживаться при исследовании объектов этой экспертизы, подробно рассмотрены ее стадии, охарактеризованы методы анализа признаков внешности. Пособие содержит приложение с альбомом рисунков основных элементов лица человека и приложения с заданиями, позволяющими проанализировать изменения признаков внешности при изменении условий получения изображений. Для экспертов, предполагающих специализироваться в области портретной идентификации и пройти обучение по экспертной специальности 5.1 «Идентификация человека по фотоснимкам и видеоизображениям».
Nico Carpentier et al. (2007). Media Technologies and Democracy in an Enlarged Europe: The Intellectual Work of the 2007 European Media and Communication Doctoral Summer School. Tartu: Tartu University Press.
Authors: Michailidou Asimina
Published: January 2022

The contested issues of enlargement and democratisation of an expanding European Union are the subjects of this book, with particular focus on the role of communication and media technologies (mediatisation). Starting with the introduction of key theoretical approaches of media and democracy, the book offers an extensive overview of contemporary empirical enquiry conducted by doctoral researchers in the fields of mediatisation of governance, participation and policy-making. The findings presented in this publication focus on, but are not limited to, European communicative spaces.
A NEGAÇÃO DA CULTURA DIGITAL PELAS ESCOLAS E SUAS CONSEQUÊCIAS NO PROCESSO DE ENSINO APRENDIZAGEM
Authors: Santos Irinaldo dos
Published: January 2022

Este artigo aborda a negação da cultura digital pela escola, numa perspectiva de compreensão para o nosso sistema de ensino fazer uma reflexão diante a sua importância no processo de ensino aprendizagem. Nos mostra também alguns paradigma na educação e falta das políticas públicas votadas para formação continuada dos professores concernente as novas tecnologias da comunicação e informação e a sua contribuição, tanto no processo metodológico e pedagógico. Mostrando também aos educadores que as TICs é algo presente na vida de nossos educando, apesar da desigualdade corroborar para exclusão digital de muitos, a escola precisa trilhar um caminho que seja diferente a negação desta cultura.
EXAME DE SUFICIÊNCIA E A MELHORA PARA A PROFISSÃO DO CONTADOR: VISÃO DOS ALUNOS, BACHARÉIS E PROFISSIONAIS EM CONTABILIDADE DO ESTADO DE RONDÔNIA
Authors: Kerr da Silva Kariny , Marques Oliveira Thyago Vinicius
Published: January 2022

Diante do tema em questão foram abordados assuntos referentes ao exame de suficiência, quando, onde e porque houve a sua instituição, além de mostrar a sua importância com relação ao profissionalismo contábil diante do mercado de trabalho. Para que isso pudesse ser mais claro e objetivo foram aplicados um questionário para alunos, discentes, profissionais e bacharéis do Estado de Rondônia com dezesseis perguntas, onde foram abordadas questões fechadas e objetivas com intuito de saber qual a relevância da aplicação do Exame de Suficiência para bacharéis do curso de Ciências Contábeis e quais são as significâncias disso para a profissão do Contador, se esta prova o ajuda a crescer profissionalmente. De acordo com que foi obtido tanto por pesquisas realizadas em artigos de temas semelhantes, tanto com a pesquisa que foi realizada por meio deste trabalho, obteve-se resultados de que a prova do exame de suficiência é de grande importância para aquele que deseja atuar no mercado de trabalho, exercendo a sua função de praxe e, que traz a valorização do profissional contábil. Diante do questionário aplicado observa-se que a aprovação e a obtenção do registro de contador não fazem com que ele seja um melhor profissional, do aquele que não tem o registro, de acordo com os respondentes há uma melhor remuneração para aquele que é contador devidamente registrado no conselho de classe, pode-se observar que muitos alunos e bacharéis que responderam ainda não realizaram o exame, e que já deveriam estar preparados, mas que ainda não estão.
Assessing the Billy Ireland Cartoon Library and Museum Collection Needs: A Case Study on Collection Surveys
Authors: Pflug Wendy
Published: January 2022

This case study examines the planning, methodology, and impact of a comprehensive collections survey at the Billy Ireland Cartoon Library and Museum at The Ohio State University Libraries. Collections consisting of original cartoon art, archives, objects, and published materials were systematically surveyed and assessed to develop a prioritized processing plan targeted at improving accessibility. The collections survey encompassed all holdings—processed and unprocessed—and all formats of materials. The survey centralized long-scattered collection information and provided the unexpected benefit of documenting institutional memory during a time of transition and expansion.