bluuebunny/crossref_metadata_2025 huggingface dataset:
Do autocomplete functions reduce the impact of dyslexia on information‐searching behavior? The case of Google
Authors: Berget Gerd , Sandnes Frode Eika
Published: October 2015

Dyslexic users often do not exhibit spelling and reading skills at a level required to perform effective search. To explore whether autocomplete functions reduce the impact of dyslexia on information searching, 20 participants with dyslexia and 20 controls solved 10 predefined tasks in the search engine Google. Eye‐tracking and screen‐capture documented the searches. There were no significant differences between the dyslexic students and the controls in time usage, number of queries, query lengths, or the use of the autocomplete function. However, participants with dyslexia made more misspellings and looked less at the screen and the autocomplete suggestions lists while entering the queries. The results indicate that although the autocomplete function supported the participants in the search process, a more extensive use of the autocomplete function would have reduced misspellings. Further, the high tolerance for spelling errors considerably reduced the effect of dyslexia, and may be as important as the autocomplete function.
Chatting through pictures? A classification of images tweeted in one week in theUKandUSA
Authors: Thelwall Mike , Goriunova Olga , Vis Farida , Faulkner Simon , Burns Anne , Aulich Jim , Mas‐Bleda Amalia , Stuart Emma , D'Orazio Francesco
Published: October 2015

Twitter is used by a substantial minority of the populations of many countries to share short messages, sometimes including images. Nevertheless, despite some research into specific images, such as selfies, and a few news stories about specific tweeted photographs, little is known about the types of images that are routinely shared. In response, this article reports a content analysis of random samples of 800 images tweeted from theUKorUSAduring a week at the end of 2014. Although most images were photographs, a substantial minority were hybrid or layered image forms: phone screenshots, collages, captioned pictures, and pictures of text messages. About half were primarily of one or more people, including 10% that were selfies, but a wide variety of other things were also pictured. Some of the images were for advertising or to share a joke but in most cases the purpose of the tweet seemed to be to share the minutiae of daily lives, performing the function of chat or gossip, sometimes in innovative ways.
Keeping up to date: An academic researcher's information journey
Authors: Pontis Sheila , Blandford Ann , Greifeneder Elke , Attalla Hesham , Neal David
Published: October 2015

Keeping up to date with research developments is a central activity of academic researchers, but researchers face difficulties in managing the rapid growth of available scientific information. This study examined how researchers stay up to date, using the information journey model as a framework for analysis and investigating which dimensions influence information behaviors. We designed a 2‐round study involving semistructured interviews and prototype testing with 61 researchers with 3 levels of seniority (PhD student to professor). Data were analyzed following a semistructured qualitative approach. Five key dimensions that influence information behaviors were identified: level of seniority, information sources, state of the project, level of familiarity, and how well defined the relevant community is. These dimensions are interrelated and their values determine the flow of the information journey. Across all levels of professional expertise, researchers used similar hard (formal) sources to access content, while soft (interpersonal) sources were used to filter information. An important “pain point” that future information tools should address is helping researchers filter information at the point of need.
Neural correlates of different self domains
Authors: Araujo Helder F. , Kaplan Jonas , Damasio Hanna , Damasio Antonio
Published: October 2015

Introduction

The neural substrates of states devoted to processing self‐related information (“self‐related states”) remain not fully elucidated. Besides the complexity of the problem, there is evidence suggesting that self‐related states vary according to the information domain being considered. Here, we investigated brain correlates for self‐related states concerning historical aspects of one's life (autobiographical self), and one's ongoing body status (core self). We focused on memory‐related regions, body‐related regions, CMSs (cortical midline structures), and ICs (insular cortices).

Methods

This was a block‐design fMRI study contrasting brain activity for core self (interoception and exteroception) and autobiographical self (personality traits and biographic facts) information domains. It involved 19 participants, who answered questions about each domain (four conditions).

Results

All conditions appeared to engage the regions of interest. Nonetheless, autobiographical self compared with core self showed greater activity in memory‐related regions (e.g., hippocampus), MPFC (medial prefrontal cortex), superior PMC (posteromedial cortex), and anterior ICs. Core self compared with autobiographical self was associated with greater activity in body‐related regions (e.g., somatosensory cortices, and EBA [extrastriate body area]), superior PMC, and posterior ICs. In addition, (1) facts compared with traits showed greater activity in body‐related regions, memory‐related regions, MPFC, and PMC; (2) traits compared with facts were associated with greater activity in the posterior part of the anterior cingulate cortex; (3) interoception compared with exteroception was associated with greater activity in body‐related regions (e.g. postcentral gyrus), memory‐related regions, MPFC, inferior PMC and ICs; (4) exteroception compared with interoception showed greater activity in some body‐related regions (e.g., premotor cortices and EBA) and superior PMC.

Conclusions

The results support the notion that the neural correlates of self‐related states depend on the information domain. Those states seem distinguishable in terms of activity in memory‐related and body‐related regions, and activity in regions that have been associated with self processes (CMSs and the ICs).
The moderating role of consumer entitlement on the relationship of value with customer satisfaction
Authors: Zboja James J. , Laird Mary Dana , Bouchet Adrien
Published: October 2015

This research provides an extension of Oliver's (1980) expectancy disconfirmation model of satisfaction by examining the moderating role of consumer entitlement in the relationships between service quality and perceived value with customer satisfaction. Using a sample of season ticket holders of the National Hockey League franchise in the southeastern USA (n = 234), we found that consumer entitlement moderates the relationship of value with satisfaction, such that the impact of consumer‐perceived service value on satisfaction is mitigated for highly entitled consumers. That is, the positive value–satisfaction relationship is stronger for individuals low in consumer entitlement. This finding suggests that highly entitled consumers' satisfaction judgments are dominated by expectations, while less entitled consumers rely more on disconfirmation assessments. Strengths, limitations, suggestions for future research, and practical implications are offered. Copyright © 2015 John Wiley & Sons, Ltd.
How character presence in advergames affects brand attitude and game performance: A cross‐cultural comparison
Authors: Choi Yung Kyun , Yoon Sukki , Taylor Charles R.
Published: October 2015

Advertising within videogames has grown in importance over the last few years. This research investigates the impact of character presence in advergames on brand attitude and game performance, and how such effects depend on national culture. A total of 130 students participated in an experiment conducted in the US and Korea. Results show that when the featured brand in an advergame was a publicly consumed product, character's presence (vs. absence) had a positive effect on attitude toward the brand and gaming performance, but when the featured brand was a privately consumed product, character's presence had a negative effect on these variables. Furthermore, the emergence of the character–product interaction effect was dependent on national culture. Theoretical and practical implications are provided. Copyright © 2015 John Wiley & Sons, Ltd.
Enhancing safe sexuality in the developmentally disabled
Authors: Fritz Gregory K.
Published: October 2015

There is now widespread recognition that individuals with developmental disabilities, just like everyone else, have the right to exercise choices regarding sexual expression. The presence of an intellectual or developmental disability does not in itself justify loss of rights related to sexuality. But despite the change in societal beliefs, translating them into practice for the developmentally disabled population remains a work in progress.
Understanding rare comorbidities in TAVR
Authors: Block Peter C.
Published: October 2015

Key Points

There seems to be an early morbidity and mortality advantage to TAVR in patients with chronic liver disease.

Patients with Childs A and B CLD can be treated with TAVR but we know little about TAVR for sicker patients.

Technical issues associated with TAVR (the use of transesophageal echocardiography (TEE) for example) have to be weighed in CLD patients with esophageal varices.
Too much data, and still not enough information
Authors: Reilly John
Published: October 2015

Key Points

This analysis of the National Inpatient Sample Database found that Medicare and Medicaid patients with peripheral arterial disease had higher rates of amputation and in‐hospital mortality as compared to private pay and Health Maintenance Organization (HMO) patients

Raising awareness of disparities of outcomes among vulnerable populations should lead all healthcare providers to examine gaps in care.

Administrative databases are necessarily limited. Prospective registries should be developed to demonstrate that early detection of PAD with simple, cost effective tests like the ankle brachial index can improve outcomes.
“I see the light!” trans‐carotid balloon valvuloplasty in neonates and small infants utilizing continuous trans‐esophageal echo guidance
Authors: Lucas Victor
Published: October 2015

Key Points

Continuous echo guidance may add to the safety of neonatal aortic balloon valvuloplasty

Trans‐carotid access is an alternative route to aortic balloon valvuloplasty in neonates

Proof of preferred procedure (surgical or catheter based), procedure setting, and access site remains elusive as the disease is infrequent and single center experience remains small
Design of Lead(II) Metal–Organic Frameworks Based on Covalent and Tetrel Bonding
Authors: Servati Gargari Masoumeh , Stilinović Vladimir , Bauzá Antonio , Frontera Antonio , McArdle Patrick , Van Derveer Donald , Ng Seik Weng , Mahmoudi Ghodrat
Published: October 2015

Three solid materials, [Pb(HL)(SCN)2]⋅CH3OH (1), [Pb(HL)(SCN)2] (2), and [Pb(L)(SCN)]n (3), were obtained from Pb(SCN)2 and an unsymmetrical bis‐pyridyl hydrazone ligand that can act both as a bridging and as a chelating ligand. In all three the lead center is hemidirectionally coordinated and is thus sterically optimal for participation in tetrel bonding. In the crystal structures of all three compounds, the lead atoms participate in short contacts with thiocyanate sulfur or nitrogen atoms. These contacts are shorter than the sums of the van der Waals radii (3.04–3.47 Å for Pb⋅⋅⋅S and 3.54 Å for Pb⋅⋅⋅N) and interconnect the covalently bonded units (monomers, dimers, and 2D polymers) into supramolecular assemblies (chains and 3D structures). DFT calculations showed these contacts to be tetrel bonds of considerable energy (6.5–10.5 kcal mol−1 for Pb⋅⋅⋅S and 16.5 kcal mol−1 for Pb⋅⋅⋅N). A survey of structures in the CSD showed that similar contacts often appear in crystals of PbII complexes with regular geometries, which leads to the conclusion that tetrel bonding plays a significant role in the supramolecular chemistry of PbII.
Mesoporous Foam TiO2 Nanomaterials for Effective Hydrogen Production
Authors: Krishnappa Manjunath , Souza Virgínia S. , Ganganagappa Nagaraju , Scholten Jackson D. , Teixeira Sérgio R. , Dupont Jairton , Thippeswamy Ramakrishnappa
Published: October 2015

Hydrolysis of TiCl4 in a diether‐functionalized imidazolium ionic liquid (IL), namely 1‐methyl‐3‐[2‐(2‐methoxy(ethoxy)ethyl]imidazolium methane sulfonate (M(MEE)I⋅CH3SO3), results in a heterostructured organic/inorganic and sponge‐like porous TiO2 material. The thermal treatment (300 °C) followed by calcination (500 °C) affords highly porous TiO2. The characterization of the obtained samples (with and without IL, before and after calcination) by XRD, SEM, and TEM reveals TiO2 anatase crystalline phases and irregular‐shaped particles with different porous structures. These hierarchical‐structured mesoporous TiO2 nanomaterials were employed as efficient photocatalysts in the water‐splitting process, yielding up to 1304 μmol g−1 on hydrogen production.
Synthesis of Long, Palladium End‐Capped Polyynes through the Use of Asymmetric 1‐Iodopolyynes
Authors: Pigulski Bartłomiej , Gulia Nurbey , Szafert Sławomir
Published: October 2015

The synthesis of a unique series of long, asymmetric 1‐iodopolyynes (1‐CnI and 2‐CnI) with the sp‐hybridized carbon chain up to a decapentayne is reported. These compounds were then used as substrates in reactions with Pd(PPh3)4 leading to another series of palladium end‐capped polyynes, which were unstable in solution. Organometallic octatetraynes 1‐C8[Pd]I, 2‐C8[Pd]I, and decapentayne 1‐C10[Pd]I are palladium end‐capped polyyne compounds with the longest carbon chains reported so far. All the complexes as well as their organic precursors were fully characterized by NMR, HRMS(ESI), IR, TGA‐DTA, and UV/Vis techniques, and the X‐ray crystal structures of two silyl‐protected precursors and one palladium complex are presented. The synthetic approach for palladium species is envisioned as a general route for the synthesis of labile organometallic polyynes.
Ultrathin g‐C3N4 Nanosheets Coupled with AgIO3 as Highly Efficient Heterostructured Photocatalysts for Enhanced Visible‐Light Photocatalytic Activity
Authors: Li Yunfeng , Li Kai , Yang Yang , Li Leijiao , Xing Yan , Song Shuyan , Jin Rongchao , Li Mei
Published: October 2015

The photocatalytic activity of graphite‐like carbon nitride (g‐C3N4) could be enhanced by heterojunction strategies through increasing the charge‐separation efficiency. As a surface‐based process, the heterogeneous photocatalytic process would become more efficient if a larger contact region existed in the heterojunction interface. In this work, ultrathin g‐C3N4 nanosheets (g‐C3N4‐NS) with much larger specific surface areas are employed instead of bulk g‐C3N4 (g‐C3N4‐B) to prepare AgIO3/g‐C3N4‐NS nanocomposite photocatalysts. By taking advantage of this feature, the as‐prepared composites exhibit remarkable performances for photocatalytic wastewater treatment under visible‐light irradiation. Notably, the optimum photocatalytic activity of AgIO3/g‐C3N4‐NS composites is almost 80.59 and 55.09 times higher than that of pure g‐C3N4‐B towards the degradation of rhodamine B and methyl orange pollutants, respectively. Finally, the stability and possible photocatalytic mechanism of the AgIO3/g‐C3N4‐NS system are also investigated.
ChemInform Abstract: Abrupt Symmetry Decrease in the ThT2Al20 Alloys (T = 3d Transition Metal).
Authors: Uziel A. , Bram A. I. , Venkert A. , Kiv A. E. , Fuks D. , Meshi L.
Published: October 2015

ThM2Al20 (M: Ti, V, Mn, Fe) alloys are prepared by arc melting of the elements followed by annealing (Ta foil in quartz capsule under Ar, 800 °C, 3 weeks).
ChemInform Abstract: From the Ternary Eu(Au/In)2 and EuAu4(Au/In)2 with Remarkable Au/In Distributions to a New Structure Type: The Gold‐Rich Eu5Au16(Au/In)6 Structure.
Authors: Steinberg Simon , Card Nathan , Mudring Anja‐Verena
Published: October 2015

The ternary compounds EuAu0.46In1.54 (I), EuAu4.75In1.25 (II), EuAu4.93In1.07, EuAu5.03In0.97, and Eu5Au17.29In4.71 (III) are prepared from the elements (Ta tubes, 800 °C for 12 h and annealing at 300 °C for 3 d).
ChemInform Abstract: New Ultraviolet B Emission from Gadolinium Activated BaZrO3 Phosphor — An Electron Paramagnetic Resonance and Optical Study.
Authors: Singh Vijay , Sivaramaiah G. , Rao J. I. , Watanabe S. , Rao T. K. Gundu , Jagtap Sujit S. , Singh P. K.
Published: October 2015

BaZrO3:Gd is prepared by combustion of an aqueous solution of Ba(NO3)2, ZrO(NO3)2, Gd(NO3)3, and urea (1.
ChemInform Abstract: Narrow‐Band Green‐Emitting Phosphor Ba2LiSi7AlN12:Eu2+ with High Thermal Stability Discovered by a Single Particle Diagnosis Approach.
Authors: Takeda Takashi , Hirosaki Naoto , Funahshi Shiro , Xie Rong‐Jun
Published: October 2015

Luminescent particles of Ba2LiSi7AlN12:Eu2+ are selected from polycrystalline material obtained by firing Ba3N2, EuN, Si3N4, AlN, and Li3N under N2 in the molar ratio of Eu:Si:Al:Li = 0.8:0.2:0.58:6.42:3 (BN crucible, 1800 °C, 2 h, 1 MPa N2).
ChemInform Abstract: Perovskite Sr‐Doped LaCrO3 as a New p‐Type Transparent Conducting Oxide.
Authors: Zhang Kelvin H. L. , Du Yingge , Papadogianni Alexandra , Bierwagen Oliver , Sallis Shawn , Piper Louis F. J. , Bowden Mark E. , Shutthanandan Vaithiyalingam , Sushko Peter V. , Chambers Scott A.
Published: October 2015

La1‐xSrxCrO3 epitaxial films are grown on SrTiO3 (001 orientation) substrates by molecular beam epitaxy.
ChemInform Abstract: High‐Pressure Synthesis of Novel Boron Oxynitride B6N4O3 with Sphalerite Type Structure.
Authors: Riedel Ralf , et al.
Published: October 2015

B6N4O3 is obtained by ball milling of a 1:3 mixture of B2O3 and h‐BN followed by hot pressing (multianvil apparatus, 15.6 GPa, 1900 °C, 20 min).
ChemInform Abstract: Insertion of Trivalent Lanthanides into Uranyl Vanadate Layers and Frameworks.
Authors: Wang Shuao , et al.
Published: October 2015

The crystal structures of compounds (III), (IV), (VI) and (VII) are determined by single crystal XRD.
ChemInform Abstract: Catalytic Enantioselective Reaction of α‐Aminoacetonitriles Using Chiral Bis(imidazoline) Palladium Catalysts.
Authors: Kondo Masaru , Nishi Tomoki , Hatanaka Tsubasa , Funahashi Yasuhiro , Nakamura Shuichi
Published: October 2015

α,β‐ and α,α‐ Diaminoacetonitriles are highly syn‐selectively and enantioselectively obtained by reaction of N‐protected α‐aminoacetonitriles with various imines in the presence of a chiral Pd‐catalyst.
ChemInform Abstract: Direct Catalytic Asymmetric Conjugate Addition of Saturated and Unsaturated Thioamides.
Authors: Majumdar Nilanjana , Saito Akira , Yin Liang , Kumagai Naoya , Shibasaki Masakatsu
Published: October 2015

It is found that the thioamide moiety is crucial to promote both the efficient enolization of thiolactam pronucleophiles and the subsequent stereoselective conjugate addition to α,β‐unsaturated thioamides.
ChemInform Abstract: Tandem Dehydrogenation/Oxidation/Oxidative Cyclization Approach to Wrightiadione and Its Derivatives.
Authors: Jeong Yujeong , Moon Youngtaek , Hong Sungwoo
Published: October 2015

An efficient method to construct the tetracyclic isoflavone motif through three‐step tandem dehydrogenation/oxidation/oxidative cyclization reactions with a Pd/Cu catalytic system is presented.
ChemInform Abstract: Ring‐Opening of Vinylcyclopropane‐1,1‐dicarboxylates by Boronic Acids under Ligandless Palladium Catalysis in Neat Water.
Authors: Yin JieXiang , Hyland Christopher J. T.
Published: October 2015

The reaction proceeds with remarkable regioselectivities: while unsubstituted vinylcyclopropane dicarboxylates (I) give predominantly the linear products, aryl substituted substrates (VIII) give the branched products.
ChemInform Abstract: Zinc‐Catalyzed Alkyne Oxidation/C—H Functionalization: Highly Site‐Selective Synthesis of Versatile Isoquinolones and β‐Carbolines.
Authors: Li Long , Zhou Bo , Wang Yong‐Heng , Shu Chao , Pan Yi‐Fei , Lu Xin , Ye Long‐Wu
Published: October 2015

The method is generally suitable for both intramolecular and intermolecular C—H‐functionalization and X—H insertion reactions.
ChemInform Abstract: Facile N‐Arylation of Amidines and N,N‐Disubstituted Amidines.
Authors: Yao Tuanli
Published: October 2015

A facile procedure for the reaction of amidines with in situ generated arynes to form N‐arylated amidines is presented.
ChemInform Abstract: Synthesis of 2‐Arylpyridopyrimidinones, 6‐Aryluracils, and Tri‐ and Tetrasubstituted Conjugated Alkenes via Pd‐Catalyzed Enolic C—O Bond Activation—Arylation.
Authors: Guchhait Sankar K. , Priyadarshani Garima
Published: October 2015

An efficient Pd‐catalyzed arylation process of enol‐tosylates derived from 1,3‐diones or barbituric acid with boronic acids is developed to allow the synthesis of the title compounds in generally good yields.
ChemInform Abstract: The Remarkable Catalytic Activity of Ultra‐Small Free‐CeO2 Nanoparticles in Selective Carbon—Carbon Bond Formation Reactions in Water at Room Temperature.
Authors: Banerjee Subhash
Published: October 2015

A simple and efficient protocol for selective bis‐Michael addition and mono‐allylation of active methylene compounds is presented using ultra‐small (size ≈5 nm) uncapped cerium oxide nanoparticles as a reusable catalyst in water.
ChemInform Abstract: Ligand‐Free Copper‐Catalyzed Negishi Coupling of Alkyl‐, Aryl‐, and Alkynylzinc Reagents with Heteroaryl Iodides.
Authors: Thapa Surendra , Kafle Arjun , Gurung Santosh K. , Montoya Adam , Riedel Patrick , Giri Ramesh
Published: October 2015

Cross‐coupled products of hetaryl iodides with primary, secondary, and tertiary alkylzinc reagents are obtained without β‐hydride elimination and rearrangement.
ChemInform Abstract: Ruthenium‐Catalyzed Alkoxycarbonylation of Alkenes Using Carbon Monoxide.
Authors: Wu Lipeng , Liu Qiang , Jackstell Ralf , Beller Matthias
Published: October 2015

A novel hydroesterification of alkenes with alcohols is presented.
ChemInform Abstract: Pd‐Catalyzed Regiodivergent Hydroesterification of Aryl Olefins with Phenyl Formate.
Authors: Ren Wenlong , Chang Wenju , Wang Yang , Li Jingfu , Shi Yian
Published: October 2015

Dependent on the choice of ligand, either linear or branched phenyl arylpropanoates are selectively obtained.
ChemInform Abstract: Ligand‐Controlled Product Selectivity in Gold‐Catalyzed Double Cycloisomerization of 1,11‐Dien‐3,9‐diyne Benzoates.
Authors: Rao Weidong , Susanti Dewi , Ayers Benjamin James , Chan Philip Wai Hong
Published: October 2015

Structurally complex tricyclic bridged heptenones or hexenones are prepared with high to excellent chemoselectivity by fine‐tuning of the steric properties of the biphenylphosphine ligand.
ChemInform Abstract: Enantio‐ and Diastereoselective Asymmetric Allylic Alkylation Catalyzed by a Planar‐Chiral Cyclopentadienyl Ruthenium Complex.
Authors: Kanbayashi Naoya , Hosoda Kazuki , Kato Masanori , Takii Koichiro , Okamura Taka‐aki , Onitsuka Kiyotaka
Published: October 2015

The mild reaction conditions result in the formation of chiral diketones having two vicinal stereocenters.
ChemInform Abstract: Selectfluor‐Mediated Simultaneous Cleavage of C—O and C—C Bonds in α,β‐Epoxy Ketones under Transition‐Metal‐Free Conditions: A Route to 1,2‐Diketones.
Authors: Wang Heng , Ren Shaobo , Zhang Jian , Zhang Wei , Liu Yunkui
Published: October 2015

A transition‐metal‐free, Selectfluor‐mediated reaction of aroyloxiranes gives 1,2‐diketones in moderate to good yields under oxidative conditions involving a ring‐opening/benzoyl rearrangement/C—C cleavage sequence.
ChemInform Abstract: Enantioselective Synthesis of α‐Quaternary Amino Acids by Alkylation of Deprotonated α‐Aminonitriles.
Authors: Netz Isabelle , Kucukdisli Murat , Opatz Till
Published: October 2015

An α‐alkylation of deprotonated α‐amino nitriles, prepared from chiral phenyldioxanamine (I) by Strecker reaction, leads to α‐quaternary arylglycines with high optical purity after hydrolysis and oxidative cleavage of the chiral auxiliary.
ChemInform Abstract: A Pd(II)/Mg‐La Mixed Oxide Catalyst for Cyanation of Aryl C—H Bonds and Tandem Suzuki—Cyanation Reactions.
Authors: Kishore Ramineni , Yadav Jagjit , Venu Boosa , Venugopal Akula , Lakshmi Kantam M.
Published: October 2015

A simple and efficient method for the regioselective cyanation of aromatic C—H bonds is presented using a reusable Pd(II)/Mg‐La catalyst in the presence of NH4HCO3 and dimethyl sulfoxide as the ‐CN source.
ChemInform Abstract: Synthesis of Heteroaryl Sulfonamides from Organozinc Reagents and 2,4,6‐Trichlorophenyl Chlorosulfate.
Authors: Colombe James R. , DeBergh J. Robb , Buchwald Stephen L.
Published: October 2015

Aryl‐ and heteroarylzinc reagents react with 2,4,6‐trichlorophenyl chlorosulfate (TCPC) to afford sulfonyl chlorides which are in situ converted to the corresponding sulfonamides by rapid reaction with various amines.
ChemInform Abstract: One‐Step Synthesis of Indanones Through NbCl5‐Induced Friedel—Crafts Reaction.
Authors: da Silva Barbosa Jader , da Silva Gil Valdo Jose , Constantino Mauricio Gomes
Published: October 2015

This facile protocol allows the synthesis of indanones through Friedel—Crafts reaction of dimethylacrylic acid with toluene and xylenes.
ChemInform Abstract: Efficient Synthesis of Octahydrophenanthrene Derivatives with Mild Cascade Reactions of Isochromenylium Tetrafluoroborates and Bifunctional Styrenes.
Authors: Mo Lei , Wu Lin‐Lin , Wang Shaozhong , Yao Zhu‐Jun
Published: October 2015

The title compounds are obtained as single diastereomers under mild and catalyst‐free reaction conditions involving a cascade process of [4+2]‐cyclization and subsequent intramolecular nucleophilic addition.
ChemInform Abstract: Viability of a [2 + 2 + 1] Hetero‐Pauson—Khand Cycloaddition Strategy Toward Securinega Alkaloids: Synthesis of the BCD‐Ring Core of Securinine and Related Alkaloids.
Authors: Chirkin Egor , Michel Sylvie , Poree Francois‐Hugues
Published: October 2015

A strategy starting from 4‐hydroxy‐L‐proline to the key intermediate ((S)‐I) is outlined.
ChemInform Abstract: A Synthesis of Dihydrofuran‐3(2H)‐ones.
Authors: Tata Rama Rao , Harmata Michael
Published: October 2015

Acid‐catalyzed formal 5‐endo‐trig cyclization of α′‐hydroxy α‐enones affords dihydrofuranones in excellent yields.
ChemInform Abstract: Copper‐/Silver‐Mediated Arylation of C(sp2)—H Bonds with 2‐Thiophenecarboxylic Acids.
Authors: Zhao Sheng , Liu Yue‐Jin , Yan Sheng‐Yi , Chen Fa‐Jie , Zhang Zhuo‐Zhuo , Shi Bing‐Feng
Published: October 2015

Using the newly developed bidentate directing group obtained from (pyridin‐2‐yl)isopropyl amine (PIP‐amine), the arylation of (hetero)aryl C—H bonds proceeds via a hypothetical cascade protodecarboxylation/dehydrogenative coupling sequence.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Isoxazolines from Silyl Nitronates.
Authors: Han Xiaoyu , Dong Li , Geng Caiwei , Jiao Peng
Published: October 2015

The utility of this method is demonstrated in a synthesis of (R)‐(+)‐tanikolide (XI).
ChemInform Abstract: A New Route for the Synthesis of 4‐Arylacetamido‐2‐aminothiazoles and Their Biological Evaluation.
Authors: Madhura V. , Revankar Hrishikesh M. , Kulkarni Manohar V.
Published: October 2015

In vitro antimicrobial evaluation of the synthesized compounds (III) indicate their specificity against Gram‐positive species.
ChemInform Abstract: Novel Thiadiazoles and Triazoles from 4‐Chloro‐3,5‐dimethylphenol and Their in vitro Antibacterial Screening.
Authors: Takate S. J. , Karale B. K. , Salve S. P. , Kale D. V. , Ghodechor G. S. , Zaware B. H. , Jadhav S. S.
Published: October 2015

New compounds (IIa) and (IIb) exhibit promising antibacterial activities against Escherichia coli, Salmonella typhii, Bacillus subtilis and Staphylococcus aureus.
ChemInform Abstract: Enantioselective Formation of Tertiary and Quaternary Allylic C—N Bonds via Allylation of Tetrazoles.
Authors: Xu Kun , Raimondi Wilfried , Bury Timm , Breit Bernhard
Published: October 2015

The scalable method represents the first coupling of aryl tetrazoles with mono and 1,1‐disubstituted allenes.
ChemInform Abstract: Rhodium(III)‐Catalyzed Oxidative Annulation of 7‐Azaindoles and Alkynes via Double C—H Activation.
Authors: Li Shuai‐Shuai , Wang Cheng‐Qi , Lin Hui , Zhang Xiao‐Mei , Dong Lin
Published: October 2015

Annulated 7‐azaindole derivatives are obtained via rhodium(III)‐catalyzed N‐directed ortho C—H activation and subsequent roll‐over C—H activation of the heterocyclic ring.
ChemInform Abstract: Electroreductive Coupling of 1,3‐Dimethyluracils with Aromatic Ketones: Synthesis of 6‐Substituted 1,3‐Dimethyluracils.
Authors: Kise Naoki , Miyamoto Hiroyuki , Hamada Yusuke , Sakurai Toshihiko
Published: October 2015

Electroreductive coupling of uracils (I) and (VI) with benzophenones or alkylphenylketones in the presence of TmsCl provides 6‐substituted uracils.
ChemInform Abstract: Synthesis and Fungicidal Activity of Novel 2‐Aryl‐3‐(1,3,4‐thiadiazolyl)‐6(8)‐methyl‐1,3‐benzoxazines.
Authors: Tang Zi‐long , Xia Zan‐wen , Chang Shu‐hong , Wang Zhao‐xu
Published: October 2015

Among the tested compounds, derivative (IIIc) shows up to 98% fungicidal activity against S.
ChemInform Abstract: Divergent Functionalization of Indoles with Acryloyl Silanes via Rhodium‐Catalyzed C—H Activation.
Authors: Lu Ping , Feng Chao , Loh Teck‐Peng
Published: October 2015

Depending on Rh catalyst and conditions either regioselective alkylation or alkenylation at 2‐position of indoles and pyrroles is achieved.
ChemInform Abstract: Topochemical Mechanoactivated Phosphonylethynylation of Pyrroles with Chloroethynylphosphonates on Solid Al2O3 or K2CO3 Media.
Authors: Gotsko Maxim D. , Sobenina Lyubov' N. , Tomilin Denis N. , Ushakov Igor' A. , Dogadina Albina V. , Trofimov Boris A.
Published: October 2015

The phosphonylethynylation of pyrroles is achieved by grinding the substrates and Al2O3 intensively for 5 ‐ 10 minutes followed by standing of the reaction mixture under air.
ChemInform Abstract: Stereogenic Phosphorus‐Induced Diastereoselective Formation of Chiral Carbon During Nucleophilic Addition of Chiral H—P Species to Aldehydes or Ketones.
Authors: Zhang He , Sun Yong‐Ming , Yao Lan , Ji Si‐Yu , Zhao Chang‐Qiu , Han Li‐Biao
Published: October 2015

P,C‐stereogenic α‐hydroxyl phosphinates or phosphine oxides are synthesized in stability‐controlled diastereoselective reactions catalyzed by bases in up to <99:1 diastereomeric ratio.
ChemInform Abstract: α‐Hydroxy and α‐Oxo Selenoamides: Synthesis via Nucleophilic Selenocarbamoylation of Carbonyl Compounds and Characterization.
Authors: Murai Toshiaki , Mizutani Tomohiko , Ebihara Masahiro , Maruyama Toshifumi
Published: October 2015

No details are given for preparation of the α‐oxo derivatives.
ChemInform Abstract: Verruculides A and B, Two New Protein Tyrosine Phosphatase 1B Inhibitors from an Indonesian Ascidian‐Derived Penicillium verruculosum.
Authors: Yamazaki Hiroyuki , et al.
Published: October 2015

isolation, structure elucidation and biological properties
ChemInform Abstract: A New Polyoxygenated Cyclohexene (I) and a New Megastigmane Glycoside (II) from Uvaria grandiflora.
Authors: Ito Takuya , et al.
Published: October 2015

Compound (I) shows significant cytotoxicity against LU‐1 and SK‐Mel‐2 cell lines.
ChemInform Abstract: Synthesis and in vitro Antitumor Activity of a New Class of Acyclic Thioglycosides.
Authors: Elgemeie G. H. , Saber N. M.
Published: October 2015

Some of the synthesized thioglycosides show high cytotoxic activity against HEPG2 cell line.
ChemInform Abstract: Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine‐Derived Streptomyces spinoverrucosus.
Authors: Fu Peng , MacMillan John B.
Published: October 2015

The title compounds are rare natural products incorporating the amino acid ergothioneine as pyrrolizidine substituent.
ChemInform Abstract: Flavones and Triterpenes from the Leaves of Vitex peduncularis.
Authors: Rudrapaul Prasenjit , Gruner Margit , Knoelker Hans‐Joachim , Dinda Biswanath
Published: October 2015

The new flavone (I) is isolated from the leaves of Vitex peduncularis, together with four known triterpenes.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Anastatins A and B.
Authors: Pan Guojun , Ma Yantao , Yang Ke , Zhao Xia , Yang Hui , Yao Qingwei , Lu Kui , Zhu Tao , Yu Peng
Published: October 2015

Two novel flavones anastatins A (I) and B (II) are prepared from commercially available phloroglucinol in eight steps with 9% and 10% overall yield, respectively.
ChemInform Abstract: Growth and Synthesis of Mono and Few‐Layers Transition Metal Dichalcogenides by Vapour Techniques: A Review
Authors: Bosi Matteo
Published: October 2015

Review: 132 refs.
ChemInform Abstract: Insights into Mesoporous Metal Phosphonate Hybrid Materials for Catalysis
Authors: Zhu Yun‐Pei , Ren Tie‐Zhen , Yuan Zhong‐Yong
Published: October 2015

Review: 236 refs.
ChemInform Abstract: Piperazine Scaffold: A Remarkable Tool in Generation of Diverse Pharmacological Agents
Authors: Shaquiquzzaman Mohammad , Verma Garima , Marella Akranth , Akhter Mymoona , Akhtar Wasim , Khan Mohemmed Faraz , Tasneem Sharba , Alam Mohammad Mumtaz
Published: October 2015

Review: 314 refs.
ChemInform Abstract: Carbocatalysis: The State of “Metal‐Free” Catalysis
Authors: Chua Chun Kiang , Pumera Martin
Published: October 2015

Review: [latest advances in the application of chemically modified graphene as catalyst, with an emphasis on the possible effects of metallic impurities; 68 refs.
ChemInform Abstract: Transition‐Metal‐Catalyzed Hydrogen‐Transfer Annulations: Access to Heterocyclic Scaffolds
Authors: Nandakumar Avanashiappan , Midya Siba Prasad , Landge Vinod Gokulkrishna , Balaraman Ekambaram
Published: October 2015

Review: [47 refs.
ChemInform Abstract: Recent Developments in the Chemistry of Quinazolinone Alkaloids
Authors: Kshirsagar U. A.
Published: October 2015

Review: [53 refs.
ChemInform Abstract: Biologically Inspired Non‐Heme Iron‐Catalysts for Asymmetric Epoxidation; Design Principles and Perspectives
Authors: Cusso Olaf , Ribas Xavi , Costas Miquel
Published: October 2015

Review: 79 refs.
ChemInform Abstract: One‐Pot Stereocontrolled Synthesis of Bicyclic Pyrrolidine Derivatives by a Platinum—Broensted Acid Relay Cascade Reaction
Authors: Huple Deepak B. , Liu Rai‐Shung
Published: October 2015

Review: 16 refs.
ChemInform Abstract: Stereochemistry of Bistricyclic Aromatic Enes and Related Polycyclic Systems
Authors: Biedermann P. Ulrich , Agranat Israel
Published: October 2015

Review: 241 refs.
ChemInform Abstract: Synthesis of 6‐s‐Cis and 6‐s‐Trans A‐Ring Modified Vitamin D Analogues
Authors: Fernandez Susana , Hernandez‐Martin Alba , Gonzalez‐Garcia Tania , Ferrero Miguel
Published: October 2015

Review: 143 refs.
ChemInform Abstract: Gemini Analogs of Vitamin D
Authors: Pazos Gonzalo , Rivadulla Marcos L. , Perez‐Garcia Xenxo , Gandara Zoila , Perez Manuel
Published: October 2015

Review: 37 refs.
ChemInform Abstract: Convergent Strategies in Total Syntheses of Complex Terpenoids
Authors: Urabe Daisuke , Asaba Taro , Inoue Masayuki
Published: October 2015

Review: 301 refs.
ChemInform Abstract: Catalytic C‐C Bond Activations via Oxidative Addition to Transition Metals
Authors: Souillart Laetitia , Cramer Nicolai
Published: October 2015

Review: 281 refs.
ChemInform Abstract: A Cure for Catalyst Poisoning
Authors: Farmer Marcus E. , Baran Phil S.
Published: October 2015

Review: 9 refs.
ChemInform Abstract: Vanadium Catalyzed Aerobic Carbon‐Carbon Cleavage
Authors: Amadio Emanuele , Di Lorenzo Rosalia , Zonta Cristiano , Licini Giulia
Published: October 2015

Review: 91 refs.
ChemInform Abstract: Amphoteric α‐Boryl Aldehyde Linchpins in the Synthesis of Heterocycles
Authors: St. Denis Jeffrey D. , He Zhi , Yudin Andrei K.
Published: October 2015

Review: 56 refs.
ChemInform Abstract: Silicon‐Assisted Synthesis and Functionalization of Sulfurated and Selenated Compounds
Authors: Capperucci Antonella , Tanini Damiano
Published: October 2015

Review: 126 refs.
ChemInform Abstract: Synthesis of 2‐Alkylidene‐3,1‐benzoxathiin‐4‐ones by the Pummerer Type Reaction
Authors: Yamanaka Masaki , Shimada Shigeru , Ando Wataru , Konakahara Takeo , Sakai Norio , Shimizu Masao
Published: October 2015

Review: 3 refs.
ChemInform Abstract: Utility of 2‐Cyano‐N‐(2‐hydroxyethyl)acetamide in Heterocyclic Synthesis
Authors: Gouda Moustafa Ahmed , Sabah Meshal Abdulrahim , Aljuhani Waled Khaled , El‐Gahani Ahmed Saleh , Abd El‐Karem El‐Enazi Snad , Al Enizi Salem Atalleh , Al‐Balawi Majed Musallam
Published: October 2015

Review: 34 refs.
ChemInform Abstract: Cu/Fe‐Catalyzed Carbon—Carbon and Carbon—Heteroatom Cross‐Coupling Reactions
Authors: Panda Niranjan , Jena Ashis K.
Published: October 2015

Review: 206 refs.
ChemInform Abstract: Synthesis of Heterocycles and Fused Heterocycles Catalyzed by Nanomaterials
Authors: Elwahy Ahmed H. M. , Shaaban Mohamed R.
Published: October 2015

Review: [117 refs.
ChemInform Abstract: Intramolecular Morita—Baylis—Hillman and Rauhut—Currier Reactions. A Catalytic and Atom Economic Route for Carbocycles and Heterocycles
Authors: Chandra Bharadwaj Kishor
Published: October 2015

Review: [88 refs.
ChemInform Abstract: Gold Nanoparticles for Cancer Theranostics
Authors: Liang Hong , Tian Huayu , Deng Mingxiao , Chen Xuesi
Published: October 2015

Review: 160 refs.
ChemInform Abstract: Recent Progress of Innovative Perovskite Hybrid Solar Cells
Authors: Heo Jin Hyuck , Song Dae Ho , Patil Basavaraj Rudragouda , Im Sang Hyuk
Published: October 2015

Review: 92 refs.
Bottom‐Up Synthesis of Supported Thioureas and Their Use in Enantioselective Solvent‐Free Aza‐Henry and Michael Additions
Authors: Andrés José M. , de La Cruz Noelia , Valle María , Pedrosa Rafael
Published: October 2015

Two sets of supported chiral thioureas, which differ in the length of the tether that connects the chiral appendage to the polymer structure and the effective functionalization, have been prepared by copolymerization of styrene, novel styryl thioureas derived from l‐valine, and divinylbenzene. The efficiency of these polymeric thioureas has been tested in two different enantioselective transformations, namely, aza‐Henry and nitro‐Michael reactions, in neat reaction conditions. The obtained results show that it is possible to recycle the thiourea, and they are able to promote the reactions with good enantioselectivity at a low catalyst loading.
Cytologic findings in stratified mucin‐producing intraepithelial lesion of the cervix: A report of 34 cases
Authors: Backhouse Anastasia , Stewart Colin J. R. , Koay Mei Hui E. , Hunter Andrew , Tran Ha , Farrell Louise , Ruba Sukeerat
Published: October 2015

Background

Stratified mucin‐producing intraepithelial lesion (SMILE) is an uncommon variant of in situ carcinoma of the cervix. This study aimed to identify the cytologic features of SMILE since these have not been well documented previously.

Methods

The study group comprised 34 consecutive cases of SMILE encountered at a single institution in which a corresponding Papanicolaou smear, taken up to 12 months before histologic diagnosis, was available for review. The presence of associated cervical neoplastic lesions including cervical intraepithelial neoplasia (CIN), adenocarcinoma in situ (AIS), and invasive carcinoma was recorded. The linear extent and distribution of the SMILEs was also noted.

Results

Most Pap smears had been reported to show possible or definite high‐grade CIN although 3 cases reported the presence of a high‐grade glandular abnormality. No case had a prospective cytologic diagnosis of SMILE. Histology revealed concurrent CIN and/or AIS in all cases, and 1 specimen (3%) showed invasive adenocarcinoma. Following smear review, 23 of the 31 cases that included endocervical material showed recurrent cytologic features that appeared consistent with SMILE. These included three dimensional cell clusters with nuclear stratification and crowding, mild nuclear atypia, cytoplasmic vacuoles, mitotic figures, and apoptosis.

Conclusion

SMILE is almost always associated with additional HPV‐related neoplastic lesions although only one patient (3%) had invasive carcinoma, a lower rate than recorded in other studies. Consistent cytologic features associated with SMILE were identified but these were relatively subtle. However, increased awareness of these features may permit prospective diagnosis and this could influence patient management. Diagn. Cytopathol. 2016;44:20–25. © 2015 Wiley Periodicals, Inc.
Evaluation of a Postoperative Pain‐Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive‐Ratio Food‐Maintained Responding
Authors: Warner Emily , Krivitsky Rebecca , Cone Katherine , Atherton Phillip , Pitre Travis , Lanpher Janell , Giuvelis Denise , Bergquist Ivy , King Tamara , Bilsky Edward J. , Stevenson Glenn W.
Published: October 2015

Preclinical Research

There has been recent interest in characterizing the effects of pain‐like states on motivated behaviors in order to quantify how pain modulates goal‐directed behavior and the persistence of that behavior. The current set of experiments assessed the effects of an incisional postoperative pain manipulation on food‐maintained responding under a progressive‐ratio (PR) operant schedule. Independent variables included injury state (plantar incision or anesthesia control) and reinforcer type (grain pellet or sugar pellet); dependent variables were tactile sensory thresholds and response breakpoint. Once responding stabilized on the PR schedule, separate groups of rats received a single ventral hind paw incision or anesthesia (control condition). Incision significantly reduced breakpoints in rats responding for grain, but not sugar. In rats responding for sugar, tactile hypersensitivity recovered within 24 hr, indicating a faster recovery of incision‐induced tactile hypersensitivity compared to rats responding for grain, which demonstrated recovery at PD2. The NSAID analgesic, diclofenac (5.6 mg/kg) completely restored incision‐depressed PR operant responding and tactile sensitivity at 3 hr following incision. The PR schedule differentiated between sucrose and grain, suggesting that relative reinforcing efficacy may be an important determinant in detecting pain‐induced changes in motivated behavior. Drug Dev Res 76 : 432–441, 2015. © 2015 Wiley Periodicals, Inc.
Tolerance to apical and leaf damage of Raphanus raphanistrum in different competitive regimes
Authors: Dahlgren Elin , Lehtilä Kari
Published: October 2015

Tolerance to herbivory is an adaptation that promotes regrowth and maintains fitness in plants after herbivore damage. Here, we hypothesized that the effect of competition on tolerance can be different for different genotypes within a species and we tested how tolerance is affected by competitive regime and damage type. We inflicted apical or leaf damage in siblings of 29 families of an annual plant Raphanus raphanistrum (Brassicaceae) grown at high or low competition. There was a negative correlation of family tolerance levels between competition treatments: plant families with high tolerance to apical damage in the low competition treatment had low tolerance to apical damage in the high competition treatment and vice versa. We found no costs of tolerance, in terms of a trade‐off between tolerance to apical and leaf damage or between tolerance and competitive ability, or an allocation cost in terms of reduced fitness of highly tolerant families in the undamaged state. High tolerance bound to a specific competitive regime may entail a cost in terms of low tolerance if competitive regime changes. This could act as a factor maintaining genetic variation for tolerance.
The Discrete AlF52– Fluoroaluminate Anion in the Structure of [Tetraethylammonium]2[AlF5](H2O)2
Authors: Veryasov Gleb , Matsumoto Kazuhiko , Hagiwara Rika
Published: October 2015

The first crystallographically defined example of the discrete fluoroaluminate anion (AlF52–) was elucidated by analysis of single crystals of [Et4N]2[AlF5](H2O)2 (Et4N+ = tetraethylammonium) by X‐ray crystallography. Intentional preparation of a compound containing the Al2F93– anion by the reaction of two equivalents of [Et4N][AlF4] with [Me4N]F (Me4N+ = tetramethylammonium) resulted in the formation of [Et4N][Me4N][AlF5] with unreacted [Et4N][AlF4]. Cation exchange between these species in the presence of water furnished [Et4N]2[AlF5](H2O)2 as a precipitate containing the trigonal bipyramidal AlF52– anion. The data from the present study allows supplementing the ligand close packing (LCP) model for the third period of the periodic table. The Raman spectrum of [Et4N]2[AlF5](H2O)2 was analyzed on the basis of quantum chemical calculations.
From a Germylene to an “Inorganic Adamantane”: [{Ge4(μ‐O)2(μ‐OH)4}{W(CO)5}4]·4THF (X = OH, OR, N, C)
Authors: Kitschke Philipp , Mertens Lutz , Rüffer Tobias , Lang Heinrich , Auer Alexander A. , Mehring Michael
Published: October 2015

Invited for the cover of this issue are the group of Prof. Mehring (TU Chemnitz) and his collaboration partners Prof. Lang (TU Chemnitz) and Prof. Auer (MPI for Chemical Energy Conversion). The cover image shows an inorganic adamantane‐type structure based on a germanium oxido cluster coordinated by W(CO)5. The arrows not only represent the coordination bonds but also point to four edifices in Chemnitz, which are typical for our city with a rich historical and industrial background.
Rhodium‐catalysed cyclisation by addition of unsaturated 1,4‐dicarbonyl compounds to oleic acid methyl ester
Authors: Eschig Steven , Schirp Claudia
Published: October 2015

The Rh‐catalysis allows the one‐step synthesis of Diels–Alder‐like cycloadducts from mono‐unsaturated fatty acid and 1,4‐dicarbonyl components. In this article we report on the addition of maleic acid‐, fumaric acid‐ and acetylene dicarboxylic acid dimethyl ester to oleic acid methyl ester. In previous studies, Rh(OAc)2 showed the highest selectivity of the investigated catalysts towards the 3,6‐disubstituted‐1,2,3,6‐tetrahydro‐phthalic acid derivatives (THPA) for the addition of maleic anhydride to oleic acid. Thus, it was also used in this study. The relative configurations of the final products were identified by comparison with the Diels–Alder products, resulting from conjugated linoleic acid methylester (CLAMe) and the mentioned 1,4‐dicarbonyl compounds.

Practical applications: The Rh‐catalysis is an appropriate method to synthesise Diels–Alder‐like cycloadducts from mono‐unsaturated fatty acids derivatives and 1,4‐dicarbonyl compounds in a one‐step process. The resulting products are considered to be used as detergents, corrosion inhibitors, plasticiser or new monomeric building blocks, e.g. for polycondensation processes. The obtained polyesters can be used for several applications, e.g. for coatings or adhesives, and lead to new products with promising properties.

Diels–Alder‐like cycloadducts can be obtained in a one‐pot reaction from mono‐unsaturated fatty acids and 1,4‐dicarbonyl compounds using Rh‐catalysts. In contrast to common Diels–Alder reactions, a conjugated diene is not mandatory as educt, but will be generated in situ from the mono‐unsaturated fatty acid compound. The configurations of the resulting cyclocadducts are determined by NMR‐measurements.