bluuebunny/crossref_metadata_2025 huggingface dataset:
Keyhole approaches to intradural pathologies
Authors: Mende Klaus C. , Krätzig Theresa , Mohme Malte , Westphal Manfred , Eicker Sven O.
Published: August 2017

OBJECTIVE

Spinal tumors account for 2%–4% of all tumors of the central nervous system and can be intramedullary, intradural extramedullary, or extradural. In the past, wide approaches were used to obtain safe access to these tumors, as complete resection is the goal in treating most tumor entities. To reduce surgical complications due to large skin incisions and destabilizing laminectomies, minimally invasive approaches were established. In this study, the authors share their experience with mini-open approaches to intradural tumor pathologies.

METHODS

The authors retrospectively reviewed cases involving patients with intramedullary and intradural extramedullary lesions treated between 2009 and 2016. They present their surgical mini-open approach to the spinal cord as well as unique characteristics, key steps, and postsurgical complications for specific tumor subgroups (meningioma, neuroma, and intramedullary tumors).

RESULTS

A total of 245 intradural tumors were surgically treated during the study period. Of these lesions, 151 were intradural extramedullary meningiomas (n = 79) or neuromas (n = 72). Nine (12.5%) of the neuromas were dumbbell neuromas. Ninety-four tumors were intramedullary. The mean age of the patients was 51.4 years, and 53.9% were female. The mean duration of follow-up was 46.0 months.

All meningiomas and neuromas could be resected using a mini-open keyhole approach, but only 5.3% of the intramedullary lesions could be accessed using this technique. Of the 94 patients with intramedullary tumors, 76.6% required a laminotomy, 7.4% required a hemilaminectomy, and 10.6% required a 2-level laminectomy. Only 2 of the patients with intramedullary tumors needed stabilization for progressive cervical kyphosis during follow-up. None of the other patients developed spinal instability after undergoing surgery via the mini-open (keyhole/interlaminar) approach. There were significantly more surgery-associated complications in the large exposure group than in the patients treated with the mini-open approach (19.1% vs 9.6%, p < 0.01).

CONCLUSIONS

Intradural extramedullary and in selected cases intramedullary pathologies may safely be resected using a mini-open interlaminar approach. Avoiding laminectomy, laminotomy, and even hemilaminectomy preserves spinal stability and significantly reduces comorbidities, while still allowing for complete resection of these tumors.
Minimally invasive guidewireless, navigated pedicle screw placement: a technical report and case series
Authors: Smith Brandon W. , Joseph Jacob R. , Kirsch Michael , Strasser Mary Oakley , Smith Jacob , Park Paul
Published: August 2017

OBJECTIVE

Percutaneous pedicle screw insertion (PPSI) is a mainstay of minimally invasive spinal surgery. Traditionally, PPSI is a fluoroscopy-guided, multistep process involving traversing the pedicle with a Jamshidi needle, placement of a Kirschner wire (K-wire), placement of a soft-tissue dilator, pedicle tract tapping, and screw insertion over the K-wire. This study evaluates the accuracy and safety of PPSI with a simplified 2-step process using a navigated awl-tap followed by navigated screw insertion without use of a K-wire or fluoroscopy.

METHODS

Patients undergoing PPSI utilizing the K-wire–less technique were identified. Data were extracted from the electronic medical record. Complications associated with screw placement were recorded. Postoperative radiographs as well as CT were evaluated for accuracy of pedicle screw placement.

RESULTS

Thirty-six patients (18 male and 18 female) were included. The patients’ mean age was 60.4 years (range 23.8–78.4 years), and their mean body mass index was 28.5 kg/m2 (range 20.8–40.1 kg/m2). A total of 238 pedicle screws were placed. A mean of 6.6 pedicle screws (range 4–14) were placed over a mean of 2.61 levels (range 1–7). No pedicle breaches were identified on review of postoperative radiographs. In a subgroup analysis of the 25 cases (69%) in which CT scans were performed, 173 screws were assessed; 170 (98.3%) were found to be completely within the pedicle, and 3 (1.7%) demonstrated medial breaches of less than 2 mm (Grade B). There were no complications related to PPSI in this cohort.

CONCLUSIONS

This streamlined 2-step K-wire–less, navigated PPSI appears safe and accurate and avoids the need for radiation exposure to surgeon and staff.
Evaluation of Agronomic Traits and Drought Tolerance of Winter Wheat Accessions from the USDA-ARS National Small Grains Collection
Authors: Liu Yuxiu , Bowman Brian , Hu Yin-Gang , Liang Xi , Zhao Weidong , Wheeler Justin , Klassen Natalie , Bockelman Harold , Bonman J. , Chen Jianli
Published: August 2017

Wheat accessions from the USDA-ARS National Small Grains Collection (NSGC) are a potential genetic resource for variety improvement. This study assessed the agronomic performance and drought tolerance in 198 winter wheat accessions under irrigated and terminal drought environments in the 2012–2013 season, and repeated the test under terminal drought only during the 2013–2014 season. The 198 accessions were classified into three maturity groups, early, intermediate, and late based on heading data. In all three environments, the early accessions had the best agronomic performance, produced higher grain yield, thousand-kernel weight and grain volume weight, and had earlier heading date and shorter plant height. The intermediate accessions had similar grain yield and thousand-kernel weight as the early accessions in the irrigated environment, but had lower thousand-kernel weight in the terminal drought environments. Terminal drought had significant effects on grain yield, plant height, thousand-kernel weight, and grain volume weight. The positive correlation between GY and HD suggests that the ‘late early’ types in the early maturity were the most successful. Out of 198 accessions evaluated, twenty-three had high yield stability and drought tolerance according to the drought susceptibility index and membership function value of drought tolerance. The eight of twenty-three accessions identified (four early and four intermediate) had high grain yield in three environments. Some of these accessions have been further used in bi-parental mapping studies and by breeders for grain yield and drought tolerance improvement.
Planetary Gearbox Fault diagnosis via Joint Amplitude and Frequency Demodulation Analysis Based on Variational Mode Decomposition
Authors: Feng Zhipeng , Zhang Dong , Zuo Ming
Published: August 2017

Planetary gearbox vibration signals have strong modulation features due to the amplitude modulation and frequency modulation (AM-FM) effect of gear faults, as well as the amplitude modulation (AM) effect of time-varying vibration transfer paths, on gear meshing vibrations. This results in an involute sidebands structure in Fourier spectrum, possibly misleading fault diagnosis. The modulating frequency of both amplitude modulation (AM) and frequency modulation (FM) parts is closely related to the gear fault characteristic frequency. This inspires the idea of joint amplitude and frequency demodulation analysis, thus addressing the complex sidebands issue inherent in Fourier spectrum. Demodulation analysis requires mono-component signals for accurate estimation of instantaneous frequency, and proper selection of an AM-FM component sensitive to gear fault. To this end, we firstly decompose the complex signal into intrinsic mode functions (IMFs) via variational mode decomposition (VMD), by exploiting its capability in decomposing complex modulated signal into constituent AM-FM components. For effective application of VMD in complex planetary gearbox signal analysis, we propose a method to determine a key parameter in VMD, i.e. the number of IMFs to be separated. For accurate instantaneous frequency estimation, we decompose IMFs via empirical AM-FM decomposition, to remove the influence of AM on instantaneous frequency estimation. Then, we select the sensitive IMF that contains the main gear fault information for further demodulation analysis. In order to properly select the sensitive IMF, we propose a criterion based on the gear vibration characteristics and the VMD properties. Finally, we obtain the amplitude and frequency demodulated spectra by applying Fourier transform to the amplitude envelope and instantaneous frequency of the selected sensitive IMF. According to the characteristics exhibited in the demodulated spectra, we can detect planetary gearbox fault. The proposed method is illustrated via a numerical simulated planetary gearbox vibration signal, and is further validated using lab experimental vibration signals of a planetary gearbox. Faults on all the three types of gear (sun, planet and ring) are successfully identified.
Mechanical Resilience of Modified Bitumen at Different Cooling Rates: A Rheological and Atomic Force Microscopy Investigation
Authors: Rossi Cesare , Ashimova Saltanat , Calandra Pietro , Santo Maria , Angelico Ruggero
Published: August 2017

Due to the wide variation in geographic and climatic conditions, the search for high-performance bituminous materials is becoming more and more urgent to increase the useful life of pavements and reduce the enormous cost of road maintenance. Extensive research has been done by testing various bitumen modifiers, although most of them are petroleum-derived additives, such as polymers, rubbers and plastic, which in turn do not prevent oxidative aging of the binder. Thus, as an alternative to the most common polymeric rheological modifiers, selected binder additives falling in the categories of organosilane (P2KA), polyphosphoric acid (PPA) and food grade phospholipids (LCS) were homogeneously mixed to a base bitumen. The goal was to analyse the micro-morphology of the bitumens (neat and modified) subjected to different cooling rates and to find the corresponding correlations in the mechanical response domain. Therefore, microstructural investigations carried out by Atomic Force Microscopy (AFM) and fundamental rheological tests based on oscillatory dynamic rheology, were used to evaluate the effect of additives on the bitumen structure and compared with pristine binder as a reference. The tested bitumen additives have been shown to elicit different mechanical behaviours by varying the cooling rate. By comparing rheological data, analysed in the framework of the “weak gel” model, and AFM images, it was found that both P2KA and PPA altered the material structure in a different manner whereas LCS revealed superior performances, acting as “mechanical buffer” in the whole explored range of cooling rates.
An Improved Dispatching Method (a-HPDB) for Automated Material Handling System with Active Rolling Belt for 450 mm Wafer Fabrication
Authors: Wang Chia-Nan , Hsu Hsien-Pin , Tran Van-Vinh
Published: August 2017

The semiconductor industry is facing the transition from 300 mm to 450 mm wafer fabrication. Due to the increased size and weight, 450 mm wafers will pose unprecedented challenges on semiconductor wafer fabrication. To better handle and transport 450 mm wafers, an advanced Automated Material Handling System (AMHS) is definitely required. Though conveyor-based AMHS is expected to be suitable for 450 mm wafer fabrication, still it faces two main problems, traffic-jam problem and lot-prioritization. To address the two problems, in this research we have proposed an improved dispatching method, termed Heuristic Preemptive Dispatching Method using Activated Roller Belt (a-HPDB). We have developed some effective rules for the a-HPDB based on Activated Roller Belt (ARB). In addition, we have conducted experiments to investigate its effectiveness. Compared with the HPDB and R-HPD, two dispatching rules proposed in previous studies, our experimental results showed the a-HPDB had a better performance in terms of average lot delivery time (ALDT). For hot lots and normal lots, the a-HPDB had advantages of 4.14% and 8.92% over the HPDB and advantages of 4.89% and 8.52% over R-HPD, respectively.
Middle Cerebral Artery Stroke as Amusement Park Injury: Case Report and Review of the Literature
Authors: Baumgartle Abby , Wolfe Laura , Puri Vinay , Moeller Karen , Bertolone Salvatore , Raj Ashok
Published: August 2017

Strokes as amusement park injuries are rare, but have been reported in the literature. Only about 20 cases of cerebrovascular accidents after amusement park visits have been described. We report a healthy 12-year-old boy who presented with facial droop, slurred speech, and inability to use his right arm after riding roller coasters at a local amusement park. He was evaluated and found to have a left middle cerebral artery (MCA) infarction. The patient was treated with anticoagulants and has recovered with no major residual symptoms. It is likely that his neurological symptoms occurred due to the high head accelerations experienced on the roller coasters, which are more detrimental to children due to immature cervical spine development and muscle strength. Early diagnosis of dissection and stroke results in a favorable prognosis. Providers and parents should be aware of the potential risk of roller coasters and act quickly on neurologic changes in children that have recently been to an amusement park.
Spacio-Temporal Distribution and Tourist Impact on Airborne Bacteria in a Cave (Škocjan Caves, Slovenia)
Authors: Mulec Janez , Oarga-Mulec Andreea , Šturm Samo , Tomazin Rok , Matos Tadeja
Published: August 2017

(1) Background: Airborne microbes are an integral part of a cave ecosystem. Cave allochtonous airborne microbiota, which occurs mainly during aerosolization from an underground river, from animals, and from visitors, is particularly pronounced in show caves. The impacts of tourists and natural river aerosolization on the cave air were estimated in large cave spaces within the Škocjan Caves; (2) Methods: Simultaneously with the measurements of atmospheric parameters, cultivable airborne bacteria were impacted, counted and identified using MALDI-TOF MS (Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry); (3) Results: A mix of bacteria typically associated with humans and with natural habitats, including a large percentage of non-identified isolates, was found in the cave air. Few of the isolates were attributed to Risk Group 2. A strong positive correlation between tourist numbers and the rise in the concentration of airborne bacteria was indicated. Concentration of airborne bacteria rises to particularly high levels close to the underground river during periods of high discharge. A 10-times lower discharge reflected an approximately 20-times lower concentration of airborne bacteria; (4) Conclusions: Caves that are open and visited contain a diverse airborne microbiota originating from different sources. Enormous cave chambers that display relatively dynamic cave climate conditions do not normally support the enhancement of airborne bacterial concentrations.
Global Efficiency of Heat Engines and Heat Pumps with Non-Linear Boundary Conditions
Authors: Lundqvist Per , Öhman Henrik
Published: August 2017

Analysis of global energy efficiency of thermal systems is of practical importance for a number of reasons. Cycles and processes used in thermal systems exist in very different configurations, making comparison difficult if specific models are required to analyze specific thermal systems. Thermal systems with small temperature differences between a hot side and a cold side also suffer from difficulties due to heat transfer pinch point effects. Such pinch points are consequences of thermal systems design and must therefore be integrated in the global evaluation. In optimizing thermal systems, detailed entropy generation analysis is suitable to identify performance losses caused by cycle components. In plant analysis, a similar logic applies with the difference that the thermal system is then only a component, often industrially standardized. This article presents how a thermodynamic “black box” method for defining and comparing thermal efficiency of different size and types of heat engines can be extended to also compare heat pumps of different apparent magnitude and type. Impact of a non-linear boundary condition on reversible thermal efficiency is exemplified and a correlation of average real heat engine efficiencies is discussed in the light of linear and non-linear boundary conditions.
The Optimal Generation Cost-Based Tariff Rates for Onshore Wind Energy in Malaysia
Authors: Albani Aliashim , Ibrahim Mohd Zamri , Taib Che Mohd Imran Che , Azlina Abd Aziz
Published: August 2017

The government of Malaysia has recently decided to explore the feasibility of wind energy to generate electricity in the country. Their ambition is to achieve a measureable target in the percentage contribution of electricity generated by renewable energy technology in the national electricity generation mix. As part of this initiative, a study of wind energy policy has been conducted by identifying the optimal feed-in tariff (FiT) rates to support the development of wind energy in the country. The aim of this paper is to calculate the optimal level of tariff that is suitable with local wind conditions. A closed-form equation for optimal feed-in tariff rate of wind energy with consideration of the availability of capital allowance has been developed. The focus is on small- and utility-scale wind turbine installations. As a result, by considering the availability of capital allowance, the optimal FiT rates for small-scale wind turbines in Malaysia are between 0.9245–1.1313 RM/kWh, while utility-scale rates are between 0.7396 and 0.9050 RM/kWh. The level of FiT is changed with the changing value of economic parameters. Kudat, in northern Borneo, has been identified as a prime site for wind energy development in the country; however, more work needs to be conducted, including the development of a regional wind map and measurement of wind data at more new potential sites.
A DC Microgrid Coordinated Control Strategy Based on Integrator Current-Sharing
Authors: Gao Liyuan , Liu Yao , Ren Huisong , Guerrero Josep
Published: August 2017

The DC microgrid has become a new trend for microgrid study with the advantages of high reliability, simple control and low losses. With regard to the drawbacks of the traditional droop control strategies, an improved DC droop control strategy based on integrator current-sharing is introduced. In the strategy, the principle of eliminating deviation through an integrator is used, constructing the current-sharing term in order to make the power-sharing between different distributed generation (DG) units uniform and reasonable, which can reduce the circulating current between DG units. Furthermore, at the system coordinated control level, a hierarchical/droop control strategy based on the DC bus voltage is proposed. In the strategy, the operation modes of the AC main network and micro-sources are determined through detecting the DC voltage variation, which can ensure the power balance of the DC microgrid under different operating conditions. Meanwhile, communication is not needed between different DG units, while each DG unit needs to sample the DC bus voltage, which retains the plug-and-play feature of the DC microgrid. The proposed control strategy is validated by simulation on a DC microgrid with permanent magnet synchronous generator-based wind turbines, solar arrays and energy storage batteries, which can be applied to small commercial or residential buildings.
Investigation on a Power Coupling Steering System for Dual-Motor Drive Tracked Vehicles Based on Speed Control
Authors: Zhai Li , Huang Hong , Kavuma Steven
Published: August 2017

Double-motor drive tracked vehicles (2MDTV) are widely used in the tracked vehicle industry due to the development of electric vehicle drive systems. The aim of this paper is to solve the problem of insufficient propulsion motor torque in low-speed, small-radius steering and insufficient power in high-speed large-radius steering. In order to do this a new type of steering system with a coupling device is designed and a closed-loop control strategy based on speed is adopted to improve the lateral stability of the vehicle. The work done entails modeling and simulating the 2MDTV and the proposed control strategy in RecurDyn and Matlab/Simulink. The simulation results show that the 2MDTV with the coupling device outputs more torque and power in both steering cases compared to the 2MDTV without the coupling device, and the steering stability of the vehicle is improved by using the strategy based on speed.
Child Supervision and Burn Outcome among Admitted Patients at Major Trauma Hospitals in the Gambia
Authors: Sanyang Edrisa , Peek-Asa Corinne , Young Tracy , Fuortes Laurence
Published: August 2017

Burn-related injuries are a significant burden in children, particularly in low- and middle-income countries (LMICs), where more than 90% of burn-related pediatric deaths occur. Lack of adult supervision of children is a major risk for pediatric burn injuries. The goal of this paper was to examine the general characteristics of burns and identify burn injury outcomes among adult-supervised children compared to those who were not supervised. The study examined burn injury and clinical characteristics among all burn patients admitted to two trauma hospitals in The Gambia, West Africa. At intake in the emergency room, the treating physician or nurse determined the need for admission based on body surface area burned (BSAB), depth of burn, and other clinical considerations such as co-occurring injuries and co-morbidities. During the study period of 1 April 2014 through 31 October 2016, 105 burn patients were admitted and data were collected by the treating physician for all of them. Information about supervision was only asked for children aged five years or less. More than half (51%) of the burn patients were children under 18 years, and 22% were under 5 years. Among children under five, most (86.4%) were supervised by an adult at the time of burn event. Of the 19 supervised children, 16 (84.2%) had body area surface burned (BSAB) of less than 20%. Two of the three children without adult supervision at the time of burn event had BSAB ≥ 20%. Overall, 59% of the patients had 20% + BSAB. Females (aOR = 1.25; 95% CI = 0.43–3.62), those burned in rural towns and villages (aOR = 2.29; 95% CI = 0.69–7.57), or burned by fire or flames (aOR = 1.47; 95% CI = 0.51–4.23) had increased odds of having a BSAB ≥ 20%, although these differences were not statistically significant. Children 0–5 years or 5–18 years (aOR = 0.04, 95% CI = 0.01–0.17; aOR = 0.07, 95% CI = 0.02–0.23, respectively) were less likely to have BSAB ≥ 20% than adults. Those burned in a rural location (aOR = 9.23, 95% CI = 2.30–37.12) or by fire or flames (aOR = 6.09, 95% CI = 1.55–23.97) were more likely to die. Children 0–5 years or 5–18 years (aOR = 0.2, 95% CI = 0.03–1.18; aOR = 0.38; 95% CI = 0.11–1.570, respectively) were less likely to die. Children constitute a significant proportion of admitted burn patients, and most of them were supervised at the time of the burn event. Supervised children (compared to unsupervised children) had less severe burns. Programs that focus on burn prevention at all levels including child supervision could increase awareness and reduce burns or their severity. Programs need to be designed and evaluated with focus on the child development stage and the leading causes of burns by age group.
Awareness of Standardised Tobacco Packaging among Adults and Young People during the Final Phase of Policy Implementation in Great Britain
Authors: Bogdanovica Ilze , Opazo Breton Magdalena , Langley Tessa , Britton John
Published: August 2017

Background: In May 2016, along with the latest European Tobacco Products Directive (TPD), standardised packaging legislation was implemented in the UK. During the following 12-month transition period, both new and old types of packaging were allowed on the market. This study aimed to assess awareness of standardised packaging and other TPD changes in the UK population in March 2017, when both forms of packaging were in widespread use. Methods: We conducted two surveys—one in adults and one in young people—investigating awareness of plain packaging legislation. In young people, we also measured susceptibility to smoking using previously validated questions. We asked smokers whether they had recently changed the product they used and also whether they used any of the products that are banned by the new legislation. Results: In the adult survey, 73.5% (95% CI: 71.5–75.5%) of the participants were aware of the new legislation and 32.4% (95% CI: 30.3–34.5%) had noticed changes in tobacco packaging, this proportion being considerably higher among smokers (83.7%; 95% CI: 78.9–87.5%) than never smokers (20.7%; 95% CI: 18.2–23.4%). More than half (52.4%; 95% CI: 46.5–58.4%) were using pack sizes or shapes (typically less than 20 cigarettes or 30 g loose tobacco), that would become illegal after full TPD implementation, and 31.4% (95% CI: 26.2–37.1%) reported switching to a different product since October 2016, in most cases to a cheaper brand. Among young people, 20.2% (95% CI: 17.8–22.7%) reported that they had noticed standardised packaging, comprising 16.2% (95% CI: 13.7–19.0%) of non-susceptible never smokers, 25.6% (95% CI: 18.0–35%) of susceptible never smokers, and 49% (95% CI: 37.8–60.2%) of ever smokers. Conclusions: In the final stages of implementation, awareness of the introduction of standardised packs was highest among smokers. The TPD will cause nearly half of adult smokers to purchase larger packs, and may cause many smokers to switch to cheaper brands.
Using a Co-Creational Approach to Develop, Implement and Evaluate an Intervention to Promote Physical Activity in Adolescent Girls from Vocational and Technical Schools: A Case Control Study
Authors: Verloigne Maïté , Altenburg Teatske , Chinapaw Mai , Chastin Sebastien , Cardon Greet , De Bourdeaudhuij Ilse
Published: August 2017

Background: As physical inactivity is particularly prevalent amongst lower-educated adolescent girls, interventions are needed. Using a co-creational approach increases their engagement and might be effective. This study aimed to: (1) describe the co-creation process, (2) evaluate how girls experienced co-creation, and (3) evaluate the effect of the co-creational interventions on physical activity, individual, sociocultural and school-based factors. Methods: Three intervention schools (n = 91) and three control schools (n = 105) across Flanders participated. A questionnaire was completed pre (September–October 2014) and post (April–May 2015). In between, sessions with a co-creation group were organised to develop and implement the intervention in each intervention school. Focus groups were conducted to evaluate the co-creational process. Results: School 1 organised sport sessions for girls, school 2 organised a fitness activity and set up a Facebook page, school 3 organised a lunch walk. Girls were positive about having a voice in developing an intervention. No significant effects were found, except for small effects on extracurricular sports participation and self-efficacy. Conclusions: Using a co-creational approach amongst adolescent girls might be a feasible approach. However, as interventions were minimal, effects were limited or undetectable. Future co-creation projects could consider the most optimal co-creation process, evaluation design and intensively test this approach.
Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases
Authors: Ye Yao , Vattai Aurelia , Zhang Xi , Zhu Junyan , Thaler Christian , Mahner Sven , Jeschke Udo , Von Schönfeldt Viktoria
Published: August 2017

Normal pregnancy is a state of hypercoagulability with diminishing fibrinolytic activity, which is mainly caused by an increase of plasminogen activator inhibitor type 1 (PAI-1). PAI-1 is the main inhibitor of plasminogen activators, including tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). In human placentas, PAI-1 is expressed in extravillous interstitial trophoblasts and vascular trophoblasts. During implantation and placentation, PAI-1 is responsible for inhibiting extra cellular matrix (ECM) degradation, thereby causing an inhibition of trophoblasts invasion. In the present study, we have reviewed the literature of various reproductive diseases where PAI-1 plays a role. PAI-1 levels are increased in patients with recurrent pregnancy losses (RPL), preeclampsia, intrauterine growth restriction (IUGR), gestational diabetes mellitus (GDM) in the previous pregnancy, endometriosis and polycystic ovary syndrome (PCOS). In general, an increased expression of PAI-1 in the blood is associated with an increased risk for infertility and a worse pregnancy outcome. GDM and PCOS are related to the genetic role of the 4G/5G polymorphism of PAI-1. This review provides an overview of the current knowledge of the role of PAI-1 in reproductive diseases. PAI-1 represents a promising monitoring biomarker for reproductive diseases and may be a treatment target in the near future.
Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway
Authors: Zhang Cheng-Chen , Cao Chen-Yu , Kubo Miwa , Harada Kenichi , Yan Xi-Tao , Fukuyama Yoshiyasu , Gao Jin-Ming
Published: August 2017

Hericium erinaceus is a culinary-medicinal mushroom used traditionally in Eastern Asia to improve memory. In this work, we investigated the neuroprotective and neuritogenic effects of the secondary metabolites isolated from the MeOH extract of cultured mycelium of H. erinaceus and the primary mechanisms involved. One new dihydropyridine compound (6) and one new natural product (2) together with five known compounds (1,3–5,7) were obtained and their structures were elucidated by spectroscopic analysis, including 2D NMR and HRMS. The cell-based screening for bioactivity showed that 4-chloro-3,5-dimethoxybenzoic methyl ester (1) and a cyathane diterpenoid, erincine A (3), not only potentiated NGF-induced neurite outgrowth but also protected neuronally-differentiated cells against deprivation of NGF in PC12 pheochromocytoma cells. Additionally, compound 3 induced neuritogenesis in primary rat cortex neurons. Furthermore, our results revealed that TrkA-mediated and Erk1/2-dependant pathways could be involved in 1 and 3-promoted NGF-induced neurite outgrowth in PC12 cells.
Visual Analysis of Stochastic Trajectory Ensembles in Organic Solar Cell Design
Authors: Kottravel Sathish , Volpi Riccardo , Linares Mathieu , Ropinski Timo , Hotz Ingrid
Published: August 2017

We present a visualization system for analyzing stochastic particle trajectory ensembles, resulting from Kinetic Monte-Carlo simulations on charge transport in organic solar cells. The system supports the analysis of such trajectories in relation to complex material morphologies. It supports the inspection of individual trajectories or the entire ensemble on different levels of abstraction. Characteristic measures quantify the efficiency of the charge transport. Hence, our system led to better understanding of ensemble trajectories by: (i) Capturing individual trajectory behavior and providing an ensemble overview; (ii) Enabling exploration through linked interaction between 3D representations and plots of characteristics measures; (iii) Discovering potential traps in the material morphology; (iv) Studying preferential paths. The visualization system became a central part of the research process. As such, it continuously develops further along with the development of new hypothesis and questions from the application. Findings derived from the first visualizations, e.g., new efficiency measures, became new features of the system. Most of these features arose from discussions combining the data-perspective view from visualization with the physical background knowledge of the underlying processes. While our system has been built for a specific application, the concepts translate to data sets for other stochastic particle simulations.
Balance Performance in Collegiate Athletes: A Comparison of Balance Error Scoring System Measures
Authors: Dabbs Nicole , Sauls Nicole , Zayer Alice , Chander Harish
Published: August 2017

The assessment of balance among athletes is essential for training, prevention and rehabilitation of injuries resulting from postural instability. The purpose of the investigation was to validate the Sway Medical Balance Application (SMBA) against the Biodex Balance System (BBS) during the Balance Error Scoring System (BESS) protocol. One hundred and eighty-four Division-II male and female athletes from different sporting disciplines were evaluated using SMBA and BBS while performing all five testing conditions of the BESS. Pearson’s r correlations were used to determine the relationship between the two systems during each of the five conditions and an overall score. The significant relationship and very high correlation between the two systems validates the SMBA as a valid tool that can be used to assess balance in a time- and cost-effective manner in any setting with ease.
Trade Openness and Bank Risk-Taking Behavior: Evidence from Emerging Economies
Authors: Ashraf Badar , Arshad Sidra , Yan Liang
Published: August 2017

In this paper, we examine the impact of trade openness on bank risk-taking behavior. Using a panel dataset of 291 banks from 37 emerging countries over the period from 1998 to 2012, we find that higher trade openness decreases bank risk-taking. The results are robust when we use alternative bank risk-taking proxies and alternative estimation methods. We argue that trade openness provides diversification opportunities to banks in lending activities, which decrease overall bank risk. Further to this end, we observe that higher trade openness helps domestic banks to smooth out income volatility and decreases the impact of a financial crisis on banks.
Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies
Authors: Timmermans Marshall , Paudel Yagya , Ross Avena
Published: August 2017

The phylum proteobacteria contains a wide array of Gram-negative marine bacteria. With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a whole host of information is being revealed about the primary and secondary metabolism of marine proteobacteria. This has led to the discovery of a growing number of medically relevant natural products, including novel leads for the treatment of multidrug-resistant Staphylococcus aureus (MRSA) and cancer. Of equal interest, marine proteobacteria produce natural products whose structure and biosynthetic mechanisms differ from those of their terrestrial and actinobacterial counterparts. Notable features of secondary metabolites produced by marine proteobacteria include halogenation, sulfur-containing heterocycles, non-ribosomal peptides, and polyketides with unusual biosynthetic logic. As advances are made in the technology associated with functional genomics, such as computational sequence analysis, targeted DNA manipulation, and heterologous expression, it has become easier to probe the mechanisms for natural product biosynthesis. This review will focus on genomics driven approaches to understanding the biosynthetic mechanisms for natural products produced by marine proteobacteria.
Effects of Popular Diets without Specific Calorie Targets on Weight Loss Outcomes: Systematic Review of Findings from Clinical Trials
Authors: Anton Stephen , Hida Azumi , Heekin Kacey , Sowalsky Kristen , Karabetian Christy , Mutchie Heather , Leeuwenburgh Christiaan , Manini Todd , Barnett Tracey
Published: August 2017

The present review examined the evidence base for current popular diets, as listed in the 2016 U.S. News & World Report, on short-term (≤six months) and long-term (≥one year) weight loss outcomes in overweight and obese adults. For the present review, all diets in the 2016 U.S. News & World Report Rankings for “Best Weight-Loss Diets”, which did not involve specific calorie targets, meal replacements, supplementation with commercial products, and/or were not categorized as “low-calorie” diets were examined. Of the 38 popular diets listed in the U.S. News & World Report, 20 met our pre-defined criteria. Literature searches were conducted through PubMed, Cochrane Library, and Web of Science using preset key terms to identify all relevant clinical trials for these 20 diets. A total of 16 articles were identified which reported findings of clinical trials for seven of these 20 diets: (1) Atkins; (2) Dietary Approaches to Stop Hypertension (DASH); (3) Glycemic-Index; (4) Mediterranean; (5) Ornish; (6) Paleolithic; and (7) Zone. Of the diets evaluated, the Atkins Diet showed the most evidence in producing clinically meaningful short-term (≤six months) and long-term (≥one-year) weight loss. Other popular diets may be equally or even more effective at producing weight loss, but this is unknown at the present time since there is a paucity of studies on these diets.
Development of Wearable Sheet-Type Shear Force Sensor and Measurement System that is Insusceptible to Temperature and Pressure
Authors: Toyama Shigeru , Tanaka Yasuhiro , Shirogane Satoshi , Nakamura Takashi , Umino Tokio , Uehara Ryo , Okamoto Takuma , Igarashi Hiroshi
Published: August 2017

A sheet-type shear force sensor and a measurement system for the sensor were developed. The sensor has an original structure where a liquid electrolyte is filled in a space composed of two electrode-patterned polymer films and an elastic rubber ring. When a shear force is applied on the surface of the sensor, the two electrode-patterned films mutually move so that the distance between the internal electrodes of the sensor changes, resulting in current increase or decrease between the electrodes. Therefore, the shear force can be calculated by monitoring the current between the electrodes. Moreover, it is possible to measure two-dimensional shear force given that the sensor has multiple electrodes. The diameter and thickness of the sensor head were 10 mm and 0.7 mm, respectively. Additionally, we also developed a measurement system that drives the sensor, corrects the baseline of the raw sensor output, displays data, and stores data as a computer file. Though the raw sensor output was considerably affected by the surrounding temperature, the influence of temperature was drastically decreased by introducing a simple arithmetical calculation. Moreover, the influence of pressure simultaneously decreased after the same calculation process. A demonstrative measurement using the sensor revealed the practical usefulness for on-site monitoring.
Deformation Monitoring of Metro Tunnel with a New Ultrasonic-Based System
Authors: Xu Dong-Sheng , Zhao Yu-Meng , Liu Hua-Bei , Zhu Hong-Hu
Published: August 2017

With the rapid construction of metro tunnels in many metropolises, a fast and convenient solution to capture tunnel deformation is desired by civil engineers. This contribution reports an automatic and wireless tunnel deformation monitoring system using ultrasonic transducers. A processing algorithm of the redundant ultrasonic information (RUI) approach is proposed to improve measurement accuracy. The feasibility of this tunnel deformation monitoring method is carefully examined with various probe angles, distances, and surrounding temperature variations. The results indicate that high accuracy can be achieved with different coefficients for various probe angles and sensor distances, as well as temperatures. In addition, a physical tunnel model was fabricated to verify the new processing algorithm of the RUI approach for a wireless tunnel deformation sensing system. The test results reveal that average measurement errors decreased from 7% to 3.75% using the RUI approach. Therefore, it can be concluded that the proposed approach is well suited to the automatic detection of critical conditions such as large deformation events in metro tunnels.
An Adaptive Impedance Matching Network with Closed Loop Control Algorithm for Inductive Wireless Power Transfer
Authors: Miao Zhidong , Liu Dake , Gong Chen
Published: August 2017

For an inductive wireless power transfer (IWPT) system, maintaining a reasonable power transfer efficiency and a stable output power are two most challenging design issues, especially when coil distance varies. To solve these issues, this paper presents a novel adaptive impedance matching network (IMN) for IWPT system. In our adaptive IMN IWPT system, the IMN is automatically reconfigured to keep matching with the coils and to adjust the output power adapting to coil distance variation. A closed loop control algorithm is used to change the capacitors continually, which can compensate mismatches and adjust output power simultaneously. The proposed adaptive IMN IWPT system is working at 125 kHz for 2 W power delivered to load. Comparing with the series resonant IWPT system and fixed IMN IWPT system, the power transfer efficiency of our system increases up to 31.79% and 60% when the coupling coefficient varies in a large range from 0.05 to 0.8 for 2 W output power.
Time Heals All (Shallow) Wounds: A Lesson on Forgiveness of Ingroup Transgressors Learned by the Feyenoord Vandal Fans
Authors: Rullo Marika , Presaghi Fabio , Livi Stefano , Mazzuca Silvia , Dessi Roberto
Published: August 2017

This paper examines how a social threat posed by a deviant behavior affects second-hand forgiveness over time toward ingroup and outgroup transgressors. In Study 1, using real news reports, we investigated intergroup rivalries between soccer fans in order to understand the role of group membership in predicting the intention to forgive transgressors. Results suggested that transgressors were less likely to be forgiven by ingroup members rather than outgroup members, thus showing evidence of the black sheep effect. In Study 2 (using a different sample), we analyzed the same intergroup rivalries one year after the transgression in order to explore changes in intention to forgive over time. Results showed that, after one year, ingroup members were more likely to forgive ingroup than outgroup transgressors, but only when the threat to the group stereotype was not salient. The implications of the results for the subjective group dynamics theory and for the black sheep effect are discussed.
Influence of Mechanically Activated Electric Arc Furnace Slag on Compressive Strength of Mortars Incorporating Curing Moisture and Temperature Effects
Authors: Amin Muhammad , Khan Kaffayatullah , Saleem Muhammad , Khurram Nauman , Niazi Muhammad
Published: August 2017

In this study, the influence of mechanically activated electric arc furnace slag (EAFS) was investigated through compressive strength tests on 50 mm mortar cubes. The objective was to convert the wasteful EAFS into a useful binding material to reduce the cement content in concrete without compromising strength and economy. Four different groups of mortar were cast which include control mortar, reference fly ash mortar, mortar containing EAFS to determine its optimum fineness and replacement with cement, mortar blend containing fly ash and EAFS of optimum fineness. EAFS were identified with respect to its fineness as slag ground (SG), slag-fine (SF) 100% passing 75 µm sieve, and slag-super-fine (SSF) 100% passing 45 µm sieve. Compressive strength was measured according to ASTM C109. Specimens were cured under different temperatures and moisture to incorporate the effects of normal and hot environmental conditions. Compressive strength of mortars increases with fineness of EAFS and its strength activity index matches the ASTM C989 blast furnace slag (BFS) Grade 80 up to 30% cement substitution and Grade 100 when 10% cement substituted with SSF. The influence of curing temperatures was also significant in mortars containing SG or 10% SF where strength decreased with increasing curing temperature. However, a 20–30% and 20% cement substitution with SF produced strength comparable to control and reference fly ash mortars under moderate (40 °C) and high curing temperature (60 °C), respectively. The utilization of EAFS as binder in concrete may reduce needs for cement, as well as save environment and natural resources from depletion.
Benefit-Sharing Arrangements between Oil Companies and Indigenous People in Russian Northern Regions
Authors: Tulaeva Svetlana , Tysiachniouk Maria
Published: August 2017

This research provides an insight into various modes of benefit-sharing agreements between oil and gas companies and indigenous people in Russia’s northern regions, e.g., paternalism, corporate social responsibility, and partnership. The paper examines factors that influence benefit-sharing arrangements, such as regional specifics, dependency on international investors, corporate policies, and the level of local community organization. It analyses which instruments of benefit-sharing are most favourable, and why, for indigenous communities. The authors conducted research in three regions of Russia (Nenets Autonomous Okrug; Khanty-Mansi Autonomous Okrug, and Sakhalin) by using qualitative methodology that involved semi-structured interviews, participant observation, and document analysis. Theoretically, the paper builds on the concept of benefit-sharing arrangements combined with the social equity framework. We assessed each case study in terms of procedural and distributive equity in benefit-sharing. The paper demonstrates that the procedural equity is the highest in the partnership mode of benefit-sharing on the island of Sakhalin where companies implement globally-accepted standards recognized by investment banks. The cases in Nenets Autonomous Okrug and Khanti Mansi Autonomous Okrug represent a reset of Soviet practices on a market basis, but whereas the distributional equity may be sufficient, the procedural equity is low as decisions are made by the company in concord with regional authorities.
Sustainability and Ecological Civilization in the Age of Anthropocene: An Epistemological Analysis of the Psychosocial and “Culturalist” Interpretations of Global Environmental Risks
Authors: Heurtebise Jean-Yves
Published: August 2017

The aim of this article is to assess the validity of the culturalist explanation of unsustainability by critically examining the social–cultural interpretation of the risks on which it is epistemologically based. First, we will explore the different ways in which the notion of Anthropocene is changing our perception of risks. Second, we will analyze the limits of the social–cultural explanation of risks relative to the global (non-linear) interdependence between human activities and environmental processes that defines the Anthropocene. Third, we will introduce the Chinese concept of Ecological Civilization and analyze its cultural foundations and culturalist assumptions. Finally, we will develop the practical consequences of this critic of the social-cultural interpretation of risks and of culturalist explanations of unsustainability.