bluuebunny/crossref_metadata_2025 huggingface dataset:
Kajian Tingkat Pelayanan dan Efektivitas Fasilitas Jembatan Penyeberangan Orang pada Ruas Jalan Perintis Kemerdekaan
Authors: Aizar R. Muhammad Reza , Hajar Muhammad Ibnu , Said Lambang Basri , Massara Asma , Watono Watono
Published: June 2023

Jembatan penyeberangan orang adalah fasilitas bagi pejalan kaki yang digunakan untuk menyeberangi jalan yang padat lalu lintas menggunakan jembatan. Tujuan dari penelitian ini ialah untuk mengetahui tingkat pelayanan dan nilai efektivitas jembatan penyeberangan orang (JPO) di depan Makassar Town Square pada ruas jalan Perintis Kemerdekaan. Analisis dilakukan dengan cara menghitung volume pejalan kaki yang melalui dan yang tidak melalui jembatan penyeberangan orang (JPO) di jam sibuk pagi, siang dan sore. Berdasarkan hasil analisis data Arus (flow) didapatkan hasil sebesar Q = 0,255 pejalan kaki/m/menit, untuk analisis data keceptan rata – rata ruang (space mean speed) didapatkan hasil sebesar (Vs) = 1,200 m/menit, kecepatan rata – rata waktu (time mean speed) didapatkan hasil sebesar (Vt) = 1,204 m/menit, untuk analisis data kepadatan (density) didapatkan hasil sebesar D = 0,212 pejalan kaki/m2, dan untuk analisis data ruang (space) didapatkan hasil sebesar S = 4,712 m2/pejalan kaki. Sehingga, tingkat pelayanan jembatan penyeberangan orang di depan Makassar Town Square pada ruas jalan Perintis Kemerdekaan berada pada pada kategori LOS B. Sedangkan untuk hasil analisis data efektivitas jembatan penyeberangan orang (JPO) didapatkan hasil sebesar 43,496%, sehingga tingkat efektivitas jembatan penyeberangan orang (JPO) di depan Makassar Town Square pada ruas jalan Perintis Kemerdekaan berada pada kategori “Cukup Efektif”.
Penataan Ruang Parkir di Badan Jalan untuk Meningkatkan Kinerja Jalan AP Pettarani Rappang
Authors: Masri Kurniawan , Andiman Andi Mitra , Said Lambang Basri , Alifuddin Andi , Alkam Rani Bastari
Published: June 2023

Parkir merupakan salah satu komponen atau aspek tak terpisahkan dalam kebutuhan sistem transportasi, karena setiap perjalanan dengan kendaraan pribadi umumnya selalu dimauli dan diakhiri di tempat parkir. Sesuai dengan fungsi tersebut ruang parkir disesuaikan dengan permintaan seiring dengan kebutuhan orang berkendara untuk berada atau mengakses suatu tempat. Masalah yang terjadi pada jalan AP Pettarani Rappang adalah penyalahgunaan badan jalan sebagau area parkir pada ruas jalan yang mengakibatkan terhambatnya arus kendaraan. Hal tersebut disebabkan oleh pergerakan manuver dari kendaraan yang parkir di badan jalan. Salah satu ruas jalan utama Kabupaten Sidenreng Rappang yang sebagai badan jalannya digunakan untuk parkir kendaraan adalah jalan AP Pettarani, Rappang Kabupaten Sidenreng Rappang. Berdasarkan Hasil analisis kinerja jalan AP Pettarani rappang  didapatkan nilai kejenuhan sebesar (DS) 0,13 dengan arus lalu lintas sebesar 545 SMP/jam pada hari jum`at puncak, Kapasitas (C) sebesar 4041,85 SMP/jam kecepatan bebas (FV) sebesar 32,28 km/jam sehingga tingkat pelayanan pada jam puncak adalah A. Adanya parkir di badan jalan mengakibatkan berkurangnya lebar jalan, sehingga nilai (DS) sebesar 0,21 kapasitas menurun 2601,65 SMP/jam, kecepatan berkurang 26,48 km/jam dan tingkat pelayanan menjadi B.
Analysis of Mixing Time to The Compressive Strength of Concrete
Authors: Uzda Rabiyatul , Setiady Morgan , Hatuhely Billy
Published: June 2023

Masalah pengadukan beton yang sering terjadi di lapangan adalah pengadukan beton yang hanya menggunakan waktu estimasi (perkiraan). Hal ini akan berdampak pada terjadinya segregasi beton yang mengakibatkan mutu beton tidak terukur. Penelitian ini bertujuan untuk mengetahui nilai kuat tekan beton pada beberapa variasi waktu pengadukan untuk mendapatkan hasil kuat tekan beton yang optimum. Berdasarkan SNI 2493: 2011 Waktu pengadukan yang baik berkisar antara 2 – 4 menit serta lama waktu pengadukan uji beton di laboratorium sebaiknya 5 menit.. terdapat 3 variasi pengujian kuat tekan beton (benda uji) yaitu 3, 5, dan 7 menit. Dimana variasi ini diambil berdasarkan analisa terhadap SNI 2493: 2011 tentang Tata Cara Pengerjaan Beton dan beberapa riset terdahulu. Berdasarkan hasil pengujian kuat tekan, variasi waktu pengadukan 3 menit memperoleh kuat tekan sebesar 22,329 Mpa, 5 menit memperoleh kuat tekan sebesar 21,854 Mpa dan 7 menit memperoleh kuat tekan 19,874 Mpa. Hal ini menunjukan bahwa semakin lama waktu pengadukan semakin menurun nilai kuat tekan yang diperoleh. Nilai kuat tekan tertinggi didapat pada waktu pengadukan 3 menit yaitu 22,329 Mpa mengalami penurunan sebesar 2,12% pada waktu pengadukan 5 menit dan 10,9% pada waktu pengadukan 7 menit.
Analisis Kinerja Ruas Jalan Poros Bulukumba Akibat Aktifitas di Pasar Tanete Kabupaten Bulukumba
Authors: Faghnawi Ahrar , Mubarak Rahmat , Badaron St Fauziah , Gecong Alimin , Alkam Rani Bastari
Published: June 2023

Aktifitas di Pasar Tanete yang menggunakan lahan sampai diluar area yang telah disediakan menimbulkan gangguan lalu-lintas berupa kemacetan dan tundaan kendaraan.  Padahal, pada tahun 2012 kawasan Tanete Kecamatan Bulukumpa merupakan salah satu dari 4 (empat) Pusat Pelayanan Kawasan perkotaan (PPK) yang ditetapkan dalam RTRW Kab. Bulukumba Tahun 2012-2032. Hal ini menjadikan ciri kawasan Tanete sebagai perkotaan menjadi semakin lengkap. Sehingga, fungsi pelayanan kegiatan di Kawasan  Tanete harus dikaji atas implikasinya terhadap sistim interaksi ruang yang terjadi di dalamnya. Menjawab persoalan tersebut, penelitian ini berusaha untuk menjelaskan karakteristik dan kinerja ruas jalan poros Bulukumba-Sinjai sepanjang segmen 200 meter di depan Pasar Tanete menggunakan Manual Kapasitas Jalan Indonesia (MKJI) 1997, lewat data-data yang dikumpulkan pada hari pasar beroperasi dan tidak beropersi berupa geometrik ruas jalan, volume lalu-lintas, hambatan samping dan kecepatan aktual. Akhirnya disimpulkan bahwa tingkat pelayanan ruas jalan tersebut pada saat pasar beroperasi adalah E sementara pada saat  pasar tidak beroperasi adalah B.
Rethinking the Pedagogical Fiction of the Architectural Design Studio
Authors: Küçük İrem , Aksu Adnan
Published: June 2023

In line with the changing definitions and boundaries of architecture and the changing roles and professional description of the architect, the need to question and explore the contexts, contents, methods, techniques and tools of architectural design education is always on the agenda. The pedagogical fiction of the architectural studio is treated as a noteworthy issue that is effective in educating architects and shaping architecture. It is a matter of discussion about what the training in the studio should cover and how the content should be processed. This study, developed with an experimental approach to design, questions the architectural design studio's fiction of content and method to rethink its pedagogical coverage and processing. To materialize the discussion on the studio pedagogy, "house" as a design content and "designing in becoming" as a design method are proposed. "House" is re-conceptualized as a basic spatial structure for designing space in terms of its openness to derivation and reproduction. "Designing in becoming" is conceptualized as an experimental design method that creates instability and constructs a field of experimentation at the level of both subject and object. Accordingly, "Becomings of House" is proposed as an experimental design studio fiction through which the conceptualized content and method can be applied together. Based on the conceptualizations made in the study, the pedagogical opportunities and limitations of the proposed fiction are examined. A discussion on the pedagogy of architectural design studios towards experimental design approach is set up.
Optimizing Multiple Beam Patterns for 5G mmWave Phased Array Applications
Authors: Mohammed Jafar Ramadhan
Published: June 2023

In this paper, a new technique for shaping multiple beam patterns antenna arrays for 5G and beyond wireless massive MIMO communication systems is introduced. The technique aims to concentrate the radio energy in specific coverage areas with a desired shape by optimizing the excitation amplitudes and phases of the array elements. To assess the proposed technique, both genetic algorithm and particle swarm optimization are utilized to optimize the excitation amplitudes and phases of the array elements such that the required number of the beams, their shapes, their directions, their power magnitudes, and the desired sidelobe pattern can be achieved. Simulation results fully confirm the effectiveness of the proposed technique in generating optimized shaped patterns that can be suitably used for distributing the radiation powers over the coverage areas in the mobile communication base stations.
Estudio comparativo entre las estrategias metacognitivas y su efecto en el razonamiento lógico en los estudiantes de pedagogía
Authors: Hidalgo Portocarrero Gonzalo Efrén , Simisterra Corozo Ingris Pahola , Angulo Vargas Abby Arabella , Mina Cabrera Iván Ernesto
Published: June 2023

Introducción: Las estrategias metacognitivas de aprendizaje se convierten en un elemento clave que permite al estudiante orientarse en la información disponible mediante su organización, a través del cual desarrolla capacidades de razonamiento lógico matemático. Objetivo: analizar la forma en que las estrategias metacognitivas contribuyen en el razonamiento lógico y la resolución de problemas matemáticos en los estudiantes de la Carrera Pedagogía de la Matemática y la Física en la Universidad Técnica Luis Vargas Torres de Esmeraldas. Metodología:  paradigma centrado en el positivismo, conllevando un enfoque cuantitativo, analítico, racionalista, sistemático científico y tecnológico; aplicando como técnica la encuesta a 40 estudiantes pertenecientes a la universidad mencionada anteriormente. Resultados: el 38% de los estudiantes manifestaron que pocas veces imaginan el problema para decidir cómo resolverlo, evidenciando el aprendizaje mecánico que tienen en referencia a resolver problemas matemáticos.   Conclusión: las estrategias metacognitivas influyen significativamente en el razonamiento lógico, por lo que, en resolución de problemas matemáticos, se debe proponer una enseñanza en el que se empleen estrategias didácticas y diversas metodologías relacionadas con las estrategias metacognitivas que les permitirán a los estudiantes controlar y supervisar el uso de sus recursos cognitivos, resultante de una planificación, verificación, seguimiento, revisión y evaluación de sus logros cognitivos. Área de estudio general: matemática y ciencias. Área de estudio específica: modelación y docencia.
Management of a Rare Case of Moyamoya Disease Associated With Left Posterior Cerebral Artery Aneurysm
Authors: SAYORE Christine Milena , HAKKOU ELMehdi , OUDHRIRI Mohamed-Yassaad , BOUTARBOUCH Mahjouba , ELOUAHABI Abdessamad
Published: June 2023

Background: The association of moyamoya disease and posterior cerebral artery aneurysms is relatively rare and the prognosis is poor. The management is extremely challenging for neurosurgeons. Case Report: We report a case of a 58-year-old man with a history of moyamoya disease who admitted complaining of sudden-onset headaches, vomiting, and seizure and the investigations revealed a subarachnoid hemorrhage, intracerebral hematoma, posterior cerebral artery aneurysms on a moyamoya disease field. The patient was treated surgically by the clipping of the aneurysm, but developed three days later a complication of the MMD and died. Conclusion: The prognosis of this association is very poor, explain the fact that a therapeutic strategy should be done to reduce the mortality and to determine the best management which is surgery versus embolization and revascularization.
Efeitos de dieta hiperlipídica semi purificada em ratos
Authors: Rodrigues Carla Juliane Martins , Azevedo Ana Paula da Silva , Santos Angela Conceição Vieira dos , Almeida Samara Gomes , Lima Andreza Chagas de , Ninahuaman Maria Fernanda Melo Lopes , Olivieri Camila Mattos Rocha
Published: June 2023

Doenças cardiovasculares são responsáveis por grande parte das mortes e causas de hospitalização no mundo, portanto há necessidade de expandir estudos experimentais com modelos animais induzindo dislipidemia por via alimentar a fim de verificar causas e tratamentos. Dietas formuladas com combinação de ingredientes purificados apresentam limitações por seu alto custo. Objetivou-se a elaboração de uma ração hiperlipídica semi purificada de baixo custo para a indução de dislipidemia em ratos. Utilizou-se 21 ratos wistar divididos em três grupos, alimentados durante quatro semanas com ração controle (RN), ração teste (HLT) e ração comercial (HLC). A HLT foi elaborada a partir da RN, banha suína e ovos. Durante o experimento foram avaliados consumo da ração, peso dos ratos, dosagens bioquímicas dos lipídeos plasmáticos e também dos lipídeos hepáticos. Verificou-se que o consumo das rações HLT e HLC foi menor que RN, porém, a evolução da massa corporal foi significativamente maior para o grupo alimentado com ração hiperlipídica. Diferente da HLC, HLT não apresentou aumento significativo de gordura visceral, peso do fígado e enzimas hepáticas, quando comparada à RN. Foi observado que HLT apresentou resposta significativa para induzir alterações dos lipídeos plasmáticos, causando aumento de colesterol total, LDL-c e triglicerídeos, levando a um quadro de dislipidemia, assim como a HLC, porém com menores efeitos deletérios ao fígado e valor superior da HDL-c, indicando relação com o perfil de ácidos graxos utilizados nas rações.
COLLABORATION OF ANALYTIC HIERARCHY PROCESS AND SIMPLE ADDITIVE WEIGHTING METHOD TO DETERMINE EMPLOYEE SALARY BONUS
Authors: Setyadi Heribertus Ary , Fauzi Ahmad , Nurohim Galih Setiawan
Published: June 2023

Improving the quality of employee performance, a company needs motivation in the form of giving employee bonuses. Bonuses are additional wages given to employees for achieving the best work that has been done in a period. The environmental service of Sragen has implemented a bonus for its employees, however, the bonus has not been assessed based on supporting criteria so that it is not considered objective. This research was made to be able to help determine employee bonuses more objectively by using several criteria that became the basis for giving bonuses. The criteria used are cooperation, behavior, attendance, performance, service and adaptation. The Analytic Hierarchy Process (AHP) and Simple Additive Weighting (SAW) methods are used in this study so that the bonus calculation can be more objective. The results of the weights from the AHP will be used as a reference for the calculation of SAW. The decision support system is developed using Java programming. The system created can produce recommendations for the amount of bonuses received by each employee.

 Keywords: AHP method, SAW method, Employee Salary Bonus

 

Intisari— Dalam meningkatkan kualitas kinerja karyawan suatu perusahaan atau instansi perlu adanya motivasi berupa pemberian bonus karyawan. Bonus upah atau gaji merupakan upah tambahan yang diberikan kepada karyawan atas pencapaian pekerjaan terbaik yang telah dilakukan dalam suatu periode. Dinas Lingkungan Hidup Sragen sudah menerapkan pemberian bonus bagi karyawannya, hanya saja pemberian bonus tersebut belum menggunakan penilaian berdasarkan kriteria-kriteria penunjang sehingga dirasa belum obyektif. Kriteria yang digunakan dalam penelitian ini antara lain kerjasama, perilaku, absensi, kinerja, pelayanan dan adaptasi.  Penelitian ini dibuat dengan tujuan untuk dapat membantu menentukan bonus karyawan dengan lebih obyektif yaitu menggunakan beberapa kriteria yang menjadi dasar pemberian bonus. Metode Analytic Hierarchy Process (AHP) dan Simple Additive Weighting (SAW) digunakan dalam penelitian ini agar perhitungan bonus dapat lebih obyektif. Hasil bobot dari AHP akan dijadikan acuan untuk perhitungan SAW. Sistem pendukung keputusan dibuat menggunakan pemrograman Java. Sistem yang dibuat dapat menghasilkan rekomendasi besaran bonus gaji yang diterima masing-masing karyawan.

 Kata Kunci: metode AHP, metode SAW, bonus karyawan.
IMPLEMENTATION OF THE RIJNDAEL ALGORITHM ON WEB-BASED WHISTLEBLOWING SYSTEM
Authors: Latif Abdul , Warnilah Ai Ilah , Wildah Siti Khotimatul
Published: June 2023

In carrying out its responsibilities, an employee works for an agency or company and also works with his colleagues, whether they are co-workers or their own superiors. So it is very important for an employee to gain trust in his work environment. If there is a violation or behavior that deviates from an employee in the work environment, then there must be someone who reports it but of course by protecting the identity of the reporter. Based on these problems, the authors make and design a web-based whistle blowing application to protect the identity of people who report violations that occur in their work environment. This whistle blowing web is created using cryptographic algorithm methods. Cryptographic algorithms work by disguising data or information into a form of password that has no meaning. The author uses the Rijndael algorithm to encrypt the complainant's data. So that by using the Rijndael algorithm on this web-based Whistleblowing system, the data or reporting information will be safe in the database and it is hoped that an optimal system will be created for data and information security
MEAT IMAGE CLASSIFICATION USING DEEP LEARNING WITH RESNET152V2 ARCHITECTURE
Authors: Hidayat Taopik , Saputri Daniati Uki Eka , Aziz Faruq
Published: June 2023

Meat is a food ingredient that can be consumed by humans and consists of essential nutrients, especially protein, which are needed for various physiological functions in the human body. Beef, goat and pork are meats that are commonly used by Indonesian people as daily processed foods. A very high level of meat consumption results in a high economic value of meat consumption. However, many people do not know how to distinguish between the types of beef, mutton and pork. This study aims to classify types of beef, goat and pork using the ResNet152V2 algorithm. The data used are 600 images with 200 images of beef, 200 images of mutton and 200 images of pork. The process carried out is pre-processing using 4 stages, namely image augmentation, image sharpness process, then the image is resized to adjust the size needed by the algorithm. The last pre-processing is to perform the image normalization process. After the pre-processing is done, then the data training stage is carried out using the ResNet152V2 algorithm to build a classification model and then the model is tested against data testing to get the results of the optimal classification of pork, goat and beef images by looking at the results of accuracy and loss values.
IMPLEMENTATION OF WEIGHTED PRODUCT METHOD IN DETERMINING SELECTION THE BEST MUSIC STREAMING SERVICE APPLICATION
Authors: Utami Lilyani Asri , Febriningrum Kaffah
Published: June 2023

At this time, the music streaming service is a platform that is often easily found on every device, either through downloads from the Playstore and Appstore or the default application from the device itself. Many companies in the world are competing to create platforms and applications that provide the most complete songs. For example, several well-known music streaming service applications in Indonesia have their own innovations and characteristics, such as Spotify, Joox, Youtube Music, Apple Music, SoundCloud, and so on. This causes users to have difficulties because of several considerations in deciding how to use the application according to their needs. This study aims to assist in providing solutions to music streaming service subscribers by recommending several music streaming service applications according to the ranking results, which are the best choice for the user version of the application through a Decision Support System using the Weighted Product method based on 5 criteria: subscription rates, available features, streaming quality, music, application design, and application efficiency. The final result of this study is the ranking of applications that have the highest score in accordance with the criteria provided, namely that in first place with a value of 0.415 is Spotify as a recommendation for the best music streaming service application, and Apple Music ranks last out of the 6 alternatives that have been provided.
Sensory and Bioactive Properties Response to Reformulation and Processing of Java-Tea-Based Functional Drink: a Review
Authors: A’yuni Qurrata , Wijaya Christofora Hanny , Mastuti Titri S. , Sukarno
Published: June 2023

Java-tea-based (Orthosiphon aristatus B. Miq) functional drink is reported to have privileges, mainly its physiological functions and bioactive properties such as antioxidant activity and antihyperglycemic ability. Java-tea-based functional drinks contain bioactive compounds from natural materials, including java-tea leaves, ginger, sappan-wood, curcuma, lime, and kaffir lime. Several innovations and challenges have been carried out during its development, affecting the drinks' quality and stability. The stability of the beverage, especially in the aspects of sensory and bioactive properties, is still considered inferior. This review focuses on the formulation and processing technology conducted from 2007 to 2019. In the case of the reformulation, it showed that the addition of kaffir lime extract, lime extract, and flavor enhancer could improve the sensory properties in terms of aroma and taste. Furthermore, the changes in the specific java-tea plants' variety as the main ingredient and replacing the sucrose with non-sucrose sweeteners increased the bioactive properties. Recently, the formula has been enriched with a red fruit oil emulsion to improve the drink's appearance due to contains abundant carotenoid pigments. However, the addition also created another hurdle, particularly in the flavor sensory aspect and emulsion stability. In the case of processing, applying microencapsulation and nanoencapsulation in java-tea drinks has increased the bioactive properties, especially antioxidant activity, and antihyperglycemic, and also improved the product's stability which prolonged the shelf life. The development of java-tea-based functional drinks might become a milestone to reference other similar product development.
Analisis kemampuan berpikir kreatif siswa dalam menyelesaikan soal multiple solution task ditinjau dari gaya belajar
Authors: Avivah Nurul , Faiziyah Nuqthy
Published: June 2023

Pada penelitian ini implementasi berpikir kreatif akan diterapkan pada materi Sistem Persamaan Linier Dua Variabel (SPLDV). Penelitian ini bertujuan untuk mendeskripsikan kemampuan berpikir kreatif siswa SMP dalam menyelesaikan soal Multiple Solution Task (MST) ditinjau dari gaya belajar. Jenis penelitian ini adalah deskripsi kualitatif. Subjek penelitian ini adalah siswa kelas VII B SMPN 1 Sambi  telah menempuh materi SPLDV 2, dipilih sebanyak 2 siswa masing-masing kategori gaya belajar visual, auditory dan kinestetik. Teknik pengumpulan data menggunakan angket, tes soal, dan wawancara. Teknik keabsahan data menggunakan triangulasi metode. Hasil dari penelitian ini menunjukkan  subjek tipe belajar visual tersebut rata-rata telah memenuhi 4 indikator MST yaitu  fluency, elaboration, flexibility, dan collaboration. Subjek tipe belajar auditory memenuhi 2 indikator MST yaitu fluency dan flexibility. Subjek tipe belajar kinestetik dari hasil penelitian tersebut didapat bahwa objek tersebut telah memenuhi 4 indikator MST yaitu  fluency, elaboration, flexibility, dan originality.
SAĞLIK ÇALIŞANLARININ OLUMLU ÇOCUKLUK YAŞANTILARI İLE AKILLI TELEFON BAĞIMLILIĞI ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: ŞANLI Mehmet Emin
Published: June 2023

Bu çalışma, sağlık çalışanlarının olumlu çocukluk yaşantılarıyla akıllı telefon bağımlılığı arasında bir ilişki olup olmadığını tespit etmek amacıyla yapılmıştır. İlişkisel tanımlayıcı tipteki çalışma Batman Eğitim ve Araştırma Hastanesinde (BEAH) görev yapan 491(198 erkek, 293 kadın) sağlık çalışanın katılımıyla gerçekleştirilmiştir. Veriler “Tanıtıcı Özellikler Formu (TÖF), Akıllı Telefon Bağımlılığı Ölçeği (ATB-KF) ve Olumlu Çocukluk Yaşantıları Ölçeği (OÇYÖ)” ile toplanmıştır. Sağlık çalışanlarında olumlu çocukluk yaşantıları ile akılı telefon bağımlılığı arasında negatif ve anlamlı bir ilişkinin olduğu saptanmıştır. Ayrıca olumlu çocukluk yaşantılarının akıllı telefon bağımlılığını anlamlı bir şekilde yordadığı (p
ANALYSIS OF STUDENT WORKSHEET NEEDS IN SCIENCE PRACTICUM ACTIVITIES WITH PROBLEM-BASED LEARNING MODEL
Authors: Siregar Martina Eka , Masitoh Siti , Sumarno Alim
Published: June 2023

This study was conducted to analyze the needs of student worksheets in elementary school science practicum activities with a problem-based learning model. The needs analysis results will be the basis for making student worksheets. Needs analysis is carried out as an initial research stage on applying science practicum with a problem-based learning model. The study subjects were 10 grade IV students of SDN 010 Kundur. Researchers made observations and collected data through Google form questionnaires distributed via Whatsapp to students. Researchers also conducted interviews with class teachers related to the learning process. Researchers also conducted interviews with class teachers related to the learning process.
Financing the Arts in France1
Authors: Pflieger Sylvie
Published: June 2023

France is known as being the country of cultural interventionism. This paper tries to detail sources of funding for the arts and heritage in France coming from the State, local authorities but also companies and households, showing that the part of the State is not the largest one. Nonetheless, it is vital for cultural institutions to rely on this public funding as it can be considered as a lever for other funding. And despite the official reassuring speech in France, we can fear that public funding is going to decrease for the coming years.
Festivalisation of cultural production: experimentation, spectacularisation and immersion
Authors: Jordan Jennie
Published: June 2023

This paper reasons that the growth in arts festivals that has taken place since the 1990s has changed the nature of the cultural market and, consequently, is a major cause of the growth in the production of particular sorts of artworks that suit festival settings. Based on interviews and discussions with festival directors and arts producers, participant observation as a producer and audience member, primarily in the UK, together with examples from the literature, this paper explores the question of whether festival aesthetics and specific features of festival production and exhibition are changing the nature of the artwork produced in response to festivalisation. Three festival experience dimensions that are increasingly prevalent in the performing and visual arts are explored: experimentation, spectacularisation and immersion. It concludes that the festivalisation of cultural exhibition poses new management challenges and opportunities to produce innovative kinds of work that retain their aesthetic power.
Progress of research on graphene and its derivatives in bone and cartilage repair
Authors: Yu Shilong , You Mingke , Zhou Kai , Li Jian
Published: June 2023

In recent years, graphene and its derivatives have gained wide attention in the biomedical field due to their good physicochemical properties, biocompatibility, and bioactivity. Its good antibacterial, osteoinductive and drug-carrying properties make it a promising application in the field of orthopedic biomaterials. This paper introduces the research progress of graphene and its derivatives in bone tissue engineering and cartilage tissue engineering and presents an outlook on the future development of graphene-based materials in orthopedics.
Enzyme immobilization studied through molecular dynamic simulations
Authors: Bhattacharjee Nicholus , Alonso-Cotchico Lur , Lucas Maria Fátima
Published: June 2023

In recent years, simulations have been used to great advantage to understand the structural and dynamic aspects of distinct enzyme immobilization strategies, as experimental techniques have limitations in establishing their impact at the molecular level. In this review, we discuss how molecular dynamic simulations have been employed to characterize the surface phenomenon in the enzyme immobilization procedure, in an attempt to decipher its impact on the enzyme features, such as activity and stability. In particular, computational studies on the immobilization of enzymes using i) nanoparticles, ii) self-assembled monolayers, iii) graphene and carbon nanotubes, and iv) other surfaces are covered. Importantly, this thorough literature survey reveals that, while simulations have been primarily performed to rationalize the molecular aspects of the immobilization event, their use to predict adequate protocols that can control its impact on the enzyme properties is, up to date, mostly missing.
Requirements for market entry of gene drive-modified mosquitoes for control of vector-borne diseases: analogies to other biologic and biotechnology products
Authors: James Stephanie L. , Quemada Hector , Benedict Mark Q. , Dass Brinda
Published: June 2023

Gene drive-modified mosquitoes (GDMMs) are proposed as new tools for control and elimination of malaria and other mosquito-borne diseases, and promising results have been observed from testing conducted in containment. Although still at an early stage of development, it is important to begin now to consider approval procedures and market entry strategies for the eventual implementation of GDMMs in the context of disease control programs, as these could impact future research plans. It is expected that, as for other types of new products, those seeking to bring GDMMs to market will be required to provide sufficient information to allow the regulator(s) to determine whether the product is safe and effective for its proposed use. There already has been much emphasis on developing requirements for the biosafety components of the “safe and effective” benchmark, largely concerned with their regulation as genetically modified organisms. Other potential approval requirements have received little attention, however. Although GDMMs are expected to be implemented primarily in the context of public health programs, any regulatory analogies to other public health products, such as pharmaceuticals, vaccines, or chemical pesticides, must take into account the characteristics of live mosquito products. Typical manufacturing standards related to product identity, potency or quality will need to be adapted to GDMMs. Valuable lessons can be drawn from the regulatory approval processes for other whole organism and genetically modified (GM) organism products. Supply chain requirements, such as scale of production, location and design of production facilities, and methods of distribution and delivery, will be dependent upon the characteristics of the particular GDMM product, the conditions of use, and the region to be served. Plans for fulfilling supply chain needs can build upon experience in the development of other live insect products for use in public health and agriculture. Implementation of GDMMs would benefit from additional research on enabling technologies for long-term storage of mosquito life stages, efficient mass production, and area-wide delivery of GDMMs. Early consideration of these practical requirements for market entry will help to mitigate downstream delays in the development of these promising new technologies.
A versatile, bioengineered skin reconstruction device designed for use in austere environments
Authors: Veit Joachim G. S. , Weidow Morgan , Serban Monica A.
Published: June 2023

Austere environments in which access to medical facilities, medical personnel, or even water and electricity is limited or unavailable pose unique challenges for medical device product design. Currently existing skin substitutes are severely inadequate for the treatment of severe burns, chronic wounds, battlefield injuries, or work-related injuries in resource-limited settings. For such settings, an ideal device should be biocompatible, bioresorbable, promote tissue healing, not require trained medical personnel for deployment and use, and should enable topical drug delivery. As proof of concept for such a device, silk fibroin and an antioxidant hyaluronic acid derivative were chosen as primary constituents. The final formulation was selected to optimize tensile strength while retaining mechanical compliance and protection from reactive oxygen species (ROS). The ultimate tensile strength of the device was 438.0 KPa. Viability of dermal fibroblasts challenged with ROS-generating menadione decreased to 49.7% of control, which was rescued by pre-treatment with the hyaluronic acid derivative to 85.0% of control. The final device formulation was also tested in a standardized, validated, in vitro skin irritation test which revealed no tissue damage or statistical difference from control. Improved topical drug delivery was achieved via an integrated silk fibroin microneedle array and selective device processing to generate crosslinked/through pores. The final device including these features showed a 223% increase in small molecule epidermal permeation relative to the control. Scaffold porosity and microneedle integrity before and after application were confirmed by electron microscopy. Next, the device was designed to be self-adherent to enable deployment without the need of traditional fixation methods. Device tissue adhesive strength (12.0 MPa) was evaluated and shown to be comparable to a commercial adhesive surgical drape (12.9 MPa) and superior to an over-the-counter liquid bandage (4.1 MPa). Finally, the device’s wound healing potential was assessed in an in vitro full-thickness skin wound model which showed promising device integration into the tissue and cellular migration into and above the device. Overall, these results suggest that this prototype, specifically designed for use in austere environments, is mechanically robust, is cytocompatible, protects from ROS damage, is self-adherent without traditional fixation methods, and promotes tissue repair.
Oxidative stress and inflammation distinctly drive molecular mechanisms of diastolic dysfunction and remodeling in female and male heart failure with preserved ejection fraction rats
Authors: Zhazykbayeva Saltanat , Hassoun Roua , Herwig Melissa , Budde Heidi , Kovács Árpád , Mannherz Hans Georg , El-Battrawy Ibrahim , Tóth Attila , Schmidt Wolfgang E. , Mügge Andreas , Hamdani Nazha
Published: June 2023

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular insufficiency syndrome presenting with an ejection fraction (EF) of greater than 50% along with different proinflammatory and metabolic co-morbidities. Despite previous work provided key insights into our understanding of HFpEF, effective treatments are still limited. In the current study we attempted to unravel the molecular basis of sex-dependent differences in HFpEF pathology. We analyzed left ventricular samples from 1-year-old female and male transgenic (TG) rats homozygous for the rat Ren-2 renin gene (mRen2) characterized with hypertension and diastolic dysfunction and compared it to age-matched female and male wild type rats (WT) served as control. Cardiomyocytes from female and male TG rats exhibited an elevated titin-based stiffness (Fpassive), which was corrected to control level upon treatment with reduced glutathione indicating titin oxidation. This was accompanied with high levels of oxidative stress in TG rats with more prominent effects in female group. In vitro supplementation with heat shock proteins (HSPs) reversed the elevated Fpassive indicating restoration of their cytoprotective function. Furthermore, the TG group exhibited high levels of proinflammatory cytokines with significant alterations in apoptotic and autophagy pathways in both sexes. Distinct alterations in the expression of several proteins between both sexes suggest their differential impact on disease development and necessitate distinct treatment options. Hence, our data suggested that oxidative stress and inflammation distinctly drive diastolic dysfunction and remodeling in female and male rats with HFpEF and that the sex-dependent mechanisms contribute to HF pathology.
INTUITION: a data platform to integrate human epilepsy clinical care and support for discovery
Authors: Maharathi Biswajit , Mir Fozia , Hosur Karthik , Loeb Jeffrey A.
Published: June 2023

To make appropriate clinical decisions, clinicians consider many types of data from multiple sources to arrive at a diagnosis and plan. However, the current health systems have siloed data, making it challenging to develop information platforms that integrate this process into a single place for comprehensive clinical evaluation and research. INTUITION is a human brain integrative data system that facilitates multimodal data integration, unified storage, cohort selection, and analysis of multidisciplinary datasets. In this article, we describe the use of INTUITION to include electronic health records together with co-registered neuroimaging and EEG from patients who undergo invasive brain surgery for epilepsy. In addition to providing clinically useful visualizations and analytics to help guide surgical planning, INTUITION also links a bank of human brain epileptic tissues from specific brain locations to quantitative EEG, imaging, histology, and omics studies in a unique, completely integrated informatics platform. Having a clinically useful platform for integrating multimodal datasets can not only aid in clinical management decisions but also in creating a unique resource for research and discovery when linked to spatially mapped tissue samples.
Impact of opinion dynamics on the public health damage inflicted by COVID-19 in the presence of societal heterogeneities
Authors: Ali Rex N. , Sarkar Saswati
Published: June 2023

Introduction

Certain behavioral practices, such as wearing masks, practicing social distancing, and accepting vaccines, play a crucial role in impeding the spread of COVID-19 and reducing the severity of symptoms. Opinions regarding whether to observe such behavioral practices evolve over time through interactions via networks that overlap with but are not identical to the physical interaction networks over which the disease progresses. This necessitates the joint study of the dynamics of COVID-19 and opinion evolution.

Methods

We develop a mathematical model that can be easily adapted to a wide range of behavioral practices and captures in a computationally tractable manner the joint evolution of the disease and relevant opinions in populations of large sizes. Populations of large sizes are typically heterogeneous in that they comprise individuals of different age groups, genders, races, and underlying health conditions. Such groups have different propensities to imbibe severe forms of the disease, different physical contact, and social interaction patterns and rates. These lead to different disease and opinion dynamics in them. Our model is designed to effectively capture such diversities.

Results

Computations using our model reveal that opinion dynamics have a strong impact on fatality and hospitalization counts and the number of man-days lost due to symptoms both in the regular form of the disease and the extended forms, more commonly known as long COVID. We show that opinion dynamics in certain groups have a disproportionate impact on the overall public health attributes because they have high physical interaction rates, even when they have the lowest propensity to imbibe severe forms of the disease. This identifies a social vulnerability that malactors can utilize to inflict heavy public health damages through opinion campaigns targeting specific segments. Once such vulnerabilities are identified, which we accomplish, adequate precautions may be designed to enhance resilience to such targeted attacks and better protect public health.

Discussion

By recognizing and understanding the vulnerabilities, appropriate precautions can be developed to enhance resilience against targeted attacks and safeguard public health. Our study underscores the importance of considering opinion evolution alongside disease dynamics, providing insights into the interplay between behavioral practices, opinions, and disease outcomes. We believe that our model is a valuable tool for understanding the joint dynamics of COVID-19 and opinions. We hope that our findings will help to inform public health policy and facilitate evidence-based decision-making for public health interventions.
Measurement of solid–liquid mixing quality by using a uniform design method based on image analysis
Authors: Wu Jingyuan , Yang Kai , Wang Hua , Wang Haotian , Xiao Qingtai
Published: June 2023

Solid–liquid mixing has been a common industrial process operation. The measurement of solid–liquid mixing quality can help improve the efficiency of related industrial processes, but there is still a lack of an intuitive, accurate, and simple measurement method. As an important indicator to evaluate the solid–liquid mixing quality, the degree of solid suspension and the uniformity of solid distribution are directly related to mass transfer and reaction efficiency. Therefore, it is necessary to study the solid suspension and distribution in a solid–liquid system. In this work, the solid suspension and distribution of a solid–liquid system composed of glass beads–water stirred by the impeller are studied experimentally via digital image processing combined with statistical analysis. Specifically, images of solid–liquid mixing are first obtained using a camera and digitally processed. The area ratio of the solid in the image is proposed to reflect the degree of solid suspension, and the modified L2-star discrepancy (MD) is then used to quantify the uniformity of the solid distribution. Then, the solid–liquid mixing quality can be characterized by combining the area ratio and solid distribution. The feasibility of this method was proved by qualitative analysis of the solid–liquid mixing state and comparison with known studies. In addition, the effects of various stirring factors on the solid distribution were studied and discussed by using the proposed method. The results show that the method proposed in this paper can measure the quality of the solid–liquid mixing state more directly and is effective and accurate. Furthermore, it was used to find the best experimental parameters in this work. This method is also simpler and cheaper than many other methods. It is of great significance to improve the efficiency of chemical and metallurgical and other industrial processes.
Robust optimal dispatching model and a benefit allocation strategy for rural novel virtual power plants incorporating biomass waste energy conversion and carbon cycle utilization
Authors: Ju Liwei , Zhou Qingqing , Pan Miao , Wei Wanting , Wang Yi , Sun Jie , Pan Yushu
Published: June 2023

To optimize the utilization of rural biomass waste resources (e.g., straw and solid waste), biomass waste energy conversion (BWEC) and carbon cycle utilization (CCU) are integrated into a traditional virtual power plant, i.e., a rural BWEC-CCU-based virtual power plant. Furthermore, a fuzzy robust two-stage dispatching optimal model for the BWEC-CCU-based virtual power plant is established considering the non-determinacy from a wind power plant (WPP) and photovoltaic (PV) power. The scheduling model includes the day-ahead deterministic dispatching model and real-time uncertainty dispatching model. Among them, in the day-ahead dispatching phase, the dispatching plan is formulated with minimum operating cost and carbon emission targets. In the real-time dispatching phase, the optimal dispatching strategy is formulated aiming at minimum deviation adjustment cost by applying the Latin hypercube sampling method. The robust stochastic theory is used to describe the uncertainty. Third, in order to achieve optimal distribution of multi-agent cooperation benefits, a benefit distribution strategy based on Nash negotiation is designed considering the three-dimensional interfering factor of the marginal benefit contribution, carbon emission contribution, and deviation risk. Finally, a rural distribution network in Jiangsu province, China, is selected for case analysis, and the results show that 1) the synergistic optimal effect of BWEC and CCU is obvious, and the operation cost and deviation adjustment cost could decrease by 26.21% and 39.78%, respectively. While the capacity ratio of WPP + PV, BWEC, and CCU is 5:3:2, the dispatching scheme is optimum. 2) This scheduling model can be used to formulate the optimal scheduling scheme. Compared with the robust coefficient Γ = 0, when Γ = 1, the WPP and PV output decreased by 15.72% and 15.12%, and the output of BWEC and CCU increased by 30.7% and 188.19%, respectively. When Γ∈ (0.3, 0.9), the growth of Γ has the most direct impact on the dispatching scheme. 3) The proposed benefit equilibrium allocation strategy can formulate the most reasonable benefit allocation plan. Compared with the traditional benefit allocation strategy, when the proposed method is used, the benefit share of the WPP and PV reduces by 5.2%, and the benefit share of a small hydropower station, BWEC, and CCU increases by 1.7%, 9.7%, and 3.8%, respectively. Overall, the proposed optimal dispatching and benefit allocation strategy could improve the aggregated utilization of rural biomass waste resources and distributed energy resources while balancing the benefit appeal of different agents.
Livestock phenomics and genetic evaluation approaches in Africa: current state and future perspectives
Authors: Houaga Isidore , Mrode Raphael , Opoola Oluyinka , Chagunda Mizeck G. G. , Mwai Okeyo A. , Rege John E. O. , Olori Victor E. , Nash Oyekanmi , Banga Cuthbert B. , Okeno Tobias O. , Djikeng Appolinaire
Published: June 2023

The African livestock sector plays a key role in improving the livelihoods of people through the supply of food, improved nutrition and consequently health. However, its impact on the economy of the people and contribution to national GDP is highly variable and generally below its potential. This study was conducted to assess the current state of livestock phenomics and genetic evaluation methods being used across the continent, the main challenges, and to demonstrate the effects of various genetic models on the accuracy and rate of genetic gain that could be achieved. An online survey of livestock experts, academics, scientists, national focal points for animal genetic resources, policymakers, extension agents and animal breeding industry was conducted in 38 African countries. The results revealed 1) limited national livestock identification and data recording systems, 2) limited data on livestock production and health traits and genomic information, 3) mass selection was the common method used for genetic improvement with very limited application of genetic and genomic-based selection and evaluation, 4) limited human capacity, infrastructure, and funding for livestock genetic improvement programmes, as well as enabling animal breeding policies. A joint genetic evaluation of Holstein-Friesian using pooled data from Kenya and South Africa was piloted. The pilot analysis yielded higher accuracy of prediction of breeding values, pointing to possibility of higher genetic gains that could be achieved and demonstrating the potential power of multi-country evaluations: Kenya benefited on the 305-days milk yield and the age at first calving and South Africa on the age at first calving and the first calving interval. The findings from this study will help in developing harmonized protocols for animal identification, livestock data recording, and genetic evaluations (both national and across-countries) as well as in designing subsequent capacity building and training programmes for animal breeders and livestock farmers in Africa. National governments need to put in place enabling policies, the necessary infrastructure and funding for national and across country collaborations for a joint genetic evaluation which will revolutionize the livestock genetic improvement in Africa.