bluuebunny/crossref_metadata_2025 huggingface dataset:
Tendencias para el desarrollo futuro de las ciudades del Área metropolitana del Centro Occidente de Colombia
Authors: Aristizabal Mesa Luis Miguel
Published: February 2023

El Área Metropolitana AMCO del Centro occidente Colombiano incorpora las cabeceras de los municipios de Pereira, Dosquebradas y La Virginia considerándose una región dinámica en la que se pueden observar fenómenos complejos de transformación en la última década como el crecimiento poblacional por migración, el aumento de grandes infraestructuras, el aumento de los índices de desplazamiento, el desempleo, la explotación de recursos ambientales, pero a su vez factores de oportunidad como la posición estratégica en el territorio, un suelo apto para el desarrollo, lo que permitiría tener una visión a futuro basada en la integración en red de las cabeceras municipales desde una perspectiva integral, garantizando un modelo de desarrollo sostenible para los seres humanos que lo habitan con una mejor calidad de vida, desde el campo cultural, físico-ambiental y tecnológico.
Las actividades en los edificios
Authors: Osorio Valencia Juan José , Gómez Ossea Mauricio
Published: February 2023

En el taller de segundo semestre del programa de arquitectura resolvemos los problemas inherentes a la vida en los edificios, para esto asumimos el concepto de actividad, utilidad, uso y función como aquellos que permiten las cuestiones de la arquitectura, pero en igual nivel de complejidad se encuentran el sitio y la técnica. De un lado se encuentran, el sitio, la técnica, la vida y del otro se encuentra el mundo de las operaciones lógico formales. Por tanto, el mundo lógico formales, parece ser el punto en el cual reside la comprensión de la autonomía de la arquitectura. Los ejercicios de taller no desconocen la complejidad del proyecto arquitectónico pero encuentran en la vida de los edificios un amplio campo de acción, para justificarlo se exponen diez proyectos académicos.
El Proyecto
Authors: Aya Cardona Luis , Bernal Santacruz Jeferson , Medina Luis , Ospina James
Published: February 2023

The Garden of the Fallen Ones es el resultado de una serie de operaciones conceptuales y formales que parten del hecho de que el edificio debe respetar las creencias y tradiciones de todas las personas. El concepto generador de la idea es la reverencia o veneración que hace una persona de cualquier religión o corriente espiritual asumiendo una postura corporal de respeto hacia aquello en lo que enfoca su fe. Siempre se pensó el edificio desde la gente, no desde la tumba; por este motivo, el edificio es tanto una necrópolis como un ecosistema paralos vivos.
Máquina de prototipada rápido experimental
Authors: Rico Millán Lowis Douglas , Miranda Villegaz Paula Andrea , Arbélaez Ramírez Juan Sebastián
Published: February 2023

Este artículo recopila todo el proceso de in-vestigación y desarrollo de una máquina para prototipado rápido que están realizando estudiantes del programa de Diseño Industrial, pertenecientes al semillero de investigación en Tecnología y Diseño, Código B; con ella se pretende simplificar y mejorar el proceso proyectual en el programa, permitiendo generar prototipos y propuestas proyectuales de manera rápida, eficiente, garantizando buenos acabados y aplicando tecnologías apropiadas.
Las circunstancias que llevan a un cambio en el panorama religioso actual
Authors: Correa Valencia Angélica María
Published: February 2023

El presente artículo plantea como la religión a través de los tiempos ha sido un elemento forjador de la vida de la sociedad, la cultura y el pensamiento en todas las épocas y lu-gares, aportando y dando sentido a la vida de los hombres. Pero no ha sido un elemento estático, si no que ha sufrido diversas transformaciones provocadas por circunstancias particulares como lo son el cambio epocal y los diversos fenómenos emergentes que llevan a que el individuo asuma de una manera mas personal la forma como expresa y practica su religiosidad.
Immunocytochemical Detection of Glutathione S-Transferase in Peripheral Blood Lymphocytes of Rheumatoid Arthritis Patients
Authors: Ghazi Haider F. , Al-Obaidi Asmaa B. , Adnan Huda , Habib Manal A.
Published: February 2023

Background: Peripheral blood lymphocytes (PBL)of Rheumatoid arthritis (RA)patients have a property of phenotypic and functional activation. Glutathione S- transferase pi (GSTπ) has been implicated in playing an important role in the initiation and progression of cellular activation.Objectives: To determine the percentage of cellular expression of GSTπ in the lymphocytes of RA patients in comparison with controls and to explore the relation between its cellular expression and disease activity pattern.Patients and Methods: This prospective study included46 RA patients and 17 healthy controls. Blood samples were taken and from all subjects PBL were isolated and then smeared on slides. The cellular reactivity for GSTπ was determined by immunocytochemistry technique.Results: This study found lower expression of GSTπ in the RA patients with a statistical significant difference with control group, while no statistical difference was found in RA with high and minimum disease activity groups. No correlation was observed between GSTπ with Disease Activity Score (DAS).Conclusion: Although the decrease in the expression of GSTπ in PBLs was pronounced in RA patients, however it doesn’t correlate with disease activity state.
Can we predict critical care mortality with non-conventional inflammatory markers in SARS-CoV-2 infected patients?
Authors: Rozanovic Martin , Domokos Kamilla , Márovics Gergő , Rohonczi Mirtill , Csontos Csaba , Bogár Lajos , Rendeki Szilárd , Kiss Tamás , Rozanovic Melánia Nacira , Loibl Csaba
Published: February 2023

BACKGROUND: Severe COVID-19 disease is associated with multiple organ involvement,then failure and often fatal outcomes.In addition,inflammatory mechanisms and cytokine storms,documented in many COVID-19 patients,are responsible for the progression of the disease and high mortality rates.Inflammatory parameters,such as procalcitonin(PCT) and C-reactive protein(CRP), are widely used in clinical practice. OBJECTIVE: To evaluate the predictive power of non-conventional inflammatory markers regarding mortality risk. METHODS: In our prospective study 52 patients were followed for 5 days after admission to an intensive care unit immediately with severe SARS-CoV-2 infection.We compared leukocyte-,platelet antisedimentation rate (LAR, PAR),neutrophil lymphocyte ratio(NLR), CRP, PCT levels. RESULTS: In non-surviving(NSU) patients LAR remained largely constant from D1 to D4 with a statistically significant drop(p < 0.05) only seen on D5.The NSU group showed statistically significant(p < 0.05) elevated LAR medians on D4 and D5, compared to the SU group.NLR values were continually higher in the non-survivor group.The difference between the SU and NSU groups were statistically significant on every examined day.PAR, CRP and PCT levels didn’t show any significant differences between the SU and NSU groups. CONCLUSIONS: In conclusion, this study suggests that LAR and NLR are especially worthy of further investigation as prognostic markers.LAR might be of particular relevance as it is not routinely obtained in current clinical practice.It would seem beneficial to include LAR in data sets to train prognostic artificial intelligence.
Cleveland Clinic Cognitive Battery (C3B): Normative, Reliability, and Validation Studies of a Self-Administered Computerized Tool for Screening Cognitive Dysfunction in Primary Care
Authors: Rao Stephen M. , Galioto Rachel , Sokolowski Megan , Pierce Madelyn , Penn Lisa , Sturtevant Anna , Skugor Blazenka , Anstead Brent , Leverenz James B. , Schindler David , Blum David , Alberts Jay L. , Posk Lori
Published: February 2023

Background:

The self-administered iPad-based Cleveland Clinic Cognitive Battery (C3B) was designed specifically for the efficient screening of cognitive functioning of older adults in a primary care setting.

Objective:

1) Generate regression-based norms from healthy participants to enable demographic corrections to facilitate clinical interpretation; 2) estimate test-retest reliability and practice effects; 3) examine ability to discriminate mild cognitive impairment (MCI) from healthy aging; 4) d etermine validity of screening in a distracting clinical environment; and 5) determine completion rates and patient satisfaction in a primary care setting.

Methods:

Study 1 ( S1) recruited a stratified sample of 428 healthy adults, ages 18–89, to generate regression-based equations. S2 assessed 2-week test-retest reliability and practice effects in 30 healthy elders. S3 recruited 30 MCI patients and 30 demographically-matched healthy controls. In S4, 30 healthy elders self-administered the C3B in a distracting environment and in a quiet private room in counterbalanced order. In a demonstration project, 470 consecutive primary care patients were administered the C3B as part of routine clinical care ( S5).

Results:

C3B performance was primarily influenced by age, education, and race ( S1), had acceptably high test-retest reliability and minimal practice effects ( S2), discriminated MCI from healthy controls ( S3), was not negatively impacted by a distracting clinical environment ( S4), had high completion rates (>92%) and positive ratings from primary care patients ( S5).

Conclusion:

The C3B is a computerized cognitive screening tool that is reliable, validated, self-administered, and is conducive to integration into a busy primary care clinical workflow for detecting MCI, early Alzheimer’s disease, and other related dementias.
Primary Care Provider Preferences on Dementia Training: A Qualitative Study
Authors: Perales-Puchalt Jaime , Strube Kelsey , Townley Ryan , Niedens Michelle , Arreaza Hector , Zaudke Jana , Burns Jeffrey M.
Published: February 2023

Background:

Dementia has no cure, but interventions can stabilize the progression of cognitive, functional, and behavioral symptoms. Primary care providers (PCPs) are vital for the early detection, and long-term management of these diseases, given their gatekeeping role in the healthcare system. However, PCPs rarely implement evidence-based dementia care due to time limitations and knowledge about diagnosis and treatment. Training PCPs may help address these barriers.

Objective:

We explored the preferences of PCPs for dementia care training programs.

Methods:

We conducted qualitative interviews with 23 PCPs recruited nationally via snowball sampling. We conducted remote interviews and organized the transcripts for qualitative review to identify codes and themes, using thematic analysis methods.

Results:

PCP preferences varied regarding many aspects of ADRD training. Preferences varied regarding how to best increase PCP participation in training, and what content and materials were needed to help them and the families they serve. We also found differences regarding the duration and timing of training, and the modality of training sessions (remote versus in-person).

Conclusion:

The recommendations arising from these interviews have the potential to inform the development and refinement of dementia training programs to optimize their implementation and success.
Early Detection of Alzheimer’s Disease-Related Pathology Using a Multi-Disease Diagnostic Platform Employing Autoantibodies as Blood-Based Biomarkers
Authors: DeMarshall Cassandra A. , Viviano Jeffrey , Emrani Sheina , Thayasivam Umashanger , Godsey George A. , Sarkar Abhirup , Belinka Benjamin , Libon David J. , Nagele Robert G. ,   on behalf of the Parkinson’s Study Group and the Alzheimer’s Disease Neuroimaging Initiative
Published: February 2023

Background:

Evidence for the universal presence of IgG autoantibodies in blood and their potential utility for the diagnosis of Alzheimer’s disease (AD) and other neurodegenerative diseases has been extensively demonstrated by our laboratory. The fact that AD-related neuropathological changes in the brain can begin more than a decade before tell-tale symptoms emerge has made it difficult to develop diagnostic tests useful for detecting the earliest stages of AD pathogenesis.

Objective:

To determine the utility of a panel of autoantibodies for detecting the presence of AD-related pathology along the early AD continuum, including at pre-symptomatic [an average of 4 years before the transition to mild cognitive impairment (MCI)/AD)], prodromal AD (MCI), and mild-moderate AD stages.

Methods:

A total of 328 serum samples from multiple cohorts, including ADNI subjects with confirmed pre-symptomatic, prodromal, and mild-moderate AD, were screened using Luminex xMAP® technology to predict the probability of the presence of AD-related pathology. A panel of eight autoantibodies with age as a covariate was evaluated using randomForest and receiver operating characteristic (ROC) curves.

Results:

Autoantibody biomarkers alone predicted the probability of the presence of AD-related pathology with 81.0% accuracy and an area under the curve (AUC) of 0.84 (95% CI = 0.78–0.91). Inclusion of age as a parameter to the model improved the AUC (0.96; 95% CI = 0.93–0.99) and overall accuracy (93.0%).

Conclusion:

Blood-based autoantibodies can be used as an accurate, non-invasive, inexpensive, and widely accessible diagnostic screener for detecting AD-related pathology at pre-symptomatic and prodromal AD stages that could aid clinicians in diagnosing AD.
Relationship of Muscle Apolipoprotein E Expression with Markers of Cellular Stress, Metabolism, and Blood Biomarkers in Cognitively Healthy and Impaired Older Adults
Authors: Johnson Chelsea N. , McCoin Colin S. , Kueck Paul J. , Hawley Amelia G. , John Casey S. , Thyfault John P. , Swerdlow Russell H. , Geiger Paige C. , Morris Jill K.
Published: February 2023

Background:

Individuals with mild cognitive impairment (MCI) have reduced lipid-stimulated mitochondrial respiration in skeletal muscle. A major risk factor for Alzheimer’s disease (AD), the apolipoprotein E4 ( APOE4) allele, is implicated in lipid metabolism and is associated with metabolic and oxidative stress that can result from dysfunctional mitochondria. Heat shock protein 72 (Hsp72) is protective against these stressors and is elevated in the AD brain.

Objective:

Our goal was to characterize skeletal muscle ApoE and Hsp72 protein expression in APOE4 carriers in relationship to cognitive status, muscle mitochondrial respiration and AD biomarkers.

Methods:

We analyzed previously collected skeletal muscle tissue from 24 APOE4 carriers (60y+) who were cognitively healthy (CH, n = 9) or MCI ( n = 15). We measured ApoE and Hsp72 protein levels in muscle and phosphorylated tau181 (pTau181) levels in plasma, and leveraged previously collected data on APOE genotype, mitochondrial respiration during lipid oxidation, and VO2 max.

Results:

Muscle ApoE ( p = 0.013) and plasma pTau181 levels ( p < 0.001) were higher in MCI APOE4 carriers. Muscle ApoE positively correlated with plasma pTau181 in all APOE4 carriers (R2 = 0.338, p = 0.003). Hsp72 expression negatively correlated with ADP (R2 = 0.775, p = <0.001) and succinate-stimulated respiration (R2 = 0.405, p = 0.003) in skeletal muscle of MCI APOE4 carriers. Plasma pTau181 negatively tracked with VO2 max in all APOE4 carriers (R2 = 0.389, p = 0.003). Analyses were controlled for age.

Conclusion:

This work supports a relationship between cellular stress in skeletal muscle and cognitive status in APOE4 carriers.
Early Depressive Symptoms Predict Faster Dementia Progression in Autosomal-Dominant Alzheimer’s Disease
Authors: Acosta-Baena Natalia , Lopera-Gómez Carlos M. , Jaramillo-Elorza Mario C. , Velilla-Jiménez Lina , Villegas-Lanau Carlos Andrés , Sepúlveda-Falla Diego , Arcos-Burgos Mauricio , Lopera Francisco
Published: February 2023

Background:

Depression is associated with Alzheimer’s disease (AD).

Objective:

To evaluate the association between depressive symptoms and age of onset of cognitive decline in autosomal dominant AD, and to determine possible factors associated to early depressive symptoms in this population.

Methods:

We conducted a retrospective study to identify depressive symptoms among 190 presenilin 1 ( PSEN1) E280A mutation carriers, subjected to comprehensive clinical evaluations in up to a 20-year longitudinal follow-up. We controlled for the following potential confounders: APOE, sex, hypothyroidism, education, marital status, residence, tobacco, alcohol, and drug abuse.

Results:

PSEN1 E280A carriers with depressive symptoms before mild cognitive impairment (MCI) develop dementia faster than E280A carriers without depressive symptoms (Hazard Ratio, HR = 1.95; 95% CI, 1.15–3.31). Not having a stable partner accelerated the onset of MCI (HR = 1.60; 95 % CI, 1.03–2.47) and dementia (HR = 1.68; 95 % CI, 1.09–2.60). E280A carriers with controlled hypothyroidism had later age of onset of depressive symptoms (HR = 0.48; 95 % CI, 0.25–0.92), dementia (HR = 0.43; 95 % CI, 0.21–0.84), and death (HR = 0.35; 95 % CI, 0.13–0.95). APOE ɛ2 significantly affected AD progression in all stages. APOE polymorphisms were not associate to depressive symptoms. Women had a higher frequency and developed earlier depressive symptoms than men throughout the illness (HR = 1.63; 95 % CI, 1.14–2.32).

Conclusion:

Depressive symptoms accelerated progress and faster cognitive decline of autosomal dominant AD. Not having a stable partner and factors associated with early depressive symptoms (e.g., in females and individuals with untreated hypothyroidism), could impact prognosis, burden, and costs.
Cognitive and Neuropsychological Profiles in Alzheimer’s Disease and Primary Age-Related Tauopathy and the Influence of Comorbid Neuropathologies
Authors: Walker Jamie M. , Gonzales Mitzi M. , Goette William , Farrell Kurt , White III Charles L. , Crary John F. , Richardson Timothy E.
Published: February 2023

Background:

Alzheimer’s disease neuropathologic change (ADNC) is defined by the progression of both hyperphosphorylated-tau (p-tau) and amyloid-β (Aβ) and is the most common underlying cause of dementia worldwide. Primary age-related tauopathy (PART), an Aβ-negative tauopathy largely confined to the medial temporal lobe, is increasingly being recognized as an entity separate from ADNC with diverging clinical, genetic, neuroanatomic, and radiologic profiles.

Objective:

The specific clinical correlates of PART are largely unknown; we aimed to identify cognitive and neuropsychological differences between PART, ADNC, and subjects with no tauopathy (NT).

Methods:

We compared 2,884 subjects with autopsy-confirmed intermediate-high stage ADNC to 208 subjects with definite PART (Braak stage I–IV, Thal phase 0, CERAD NP score “absent”) and 178 NT subjects from the National Alzheimer’s Coordinating Center dataset.

Results:

PART subjects were older than either ADNC or NT patients. The ADNC cohort had more frequent neuropathological comorbidities as well as APOE ɛ4 alleles than the PART or NT cohort, and less frequent APOE ɛ2 alleles than either group. Clinically, ADNC patients performed significantly worse than NT or PART subjects across cognitive measures, but PART subjects had selective deficits in measures of processing speed, executive function, and visuospatial function, although additional cognitive measures were further impaired in the presence of neuropathologic comorbidities. In isolated cases of PART with Braak stage III-IV, there are additional deficits in measures of language.

Conclusion:

Overall, these findings demonstrate underlying cognitive features specifically associated with PART, and reinforce the concept that PART is a distinct entity from ADNC.
Clinical application of ABO blood typing
Authors: Lv Yin-Jiang , Liang Xiu-Feng , Wu Yi-Ping
Published: February 2023

BACKGROUND: The ABO blood group is closely related to clinical blood transfusion, transplantation, and neonatal hemolytic disease. It is also the most clinically significant blood group system in clinical blood transfusion. OBJECTIVE: The purpose of this paper is to review and analyze the clinical application of the ABO blood group. METHODS: The most common ABO blood group typing methods in clinical laboratories are hemagglutination test and microcolumn gel test, while genotype detection is mainly adopted in clinical identification of suspicious blood types. However, in some cases, the expression variation or absence of blood type antigens or antibodies, experimental techniques, physiology, disease, and other factors affect the accurate determination of blood types, which may lead to serious transfusion reactions. RESULTS: The mistakes could be reduced or even eliminated by strengthening training, selecting reasonable identification methods, and optimizing processes, thereby improving the overall identification level of the ABO blood group. ABO blood groups are also correlated with many diseases, such as COVID-19 and malignant tumors. Rh blood groups are determined by the RHD and RHCE homologous genes on chromosome 1 and are classified as Rh negative or positive according to the D antigen., the agglutination method is often used in clinical settings, while genetic and sequencing methods are often used in scientific research. CONCLUSION: Accurate ABO blood typing is a critical requirement for the safety and effectiveness of blood transfusion in clinical practice. Most studies were designed for investigating rare Rh blood group family, and there is a lack of research on the relationship between Rh blood groups and common diseases.
CT quantitative analysis of pulmonary changes in rheumatoid arthritis
Authors: Pu Doudou , Yuan Hui , Ma Guangming , Duan Haifeng , Zhang Min , Yu Nan
Published: February 2023

OBJECTIVE: To explore the application of quantitative computed tomography (CT) in analyses of lung changes in patients with rheumatoid arthritis (RA). METHODS: A total of 150 clinically diagnosed RA patients underwent chest CT and 150 matched non-smokers subjects with normal chest CT are enrolled. A CT software is applied to analyze CT obtained from both groups. The quantitative indices of emphysema are expressed as the percentage of lung area with attenuation < –950HU to the total lung volume (LAA–950%), and pulmonary fibrosis was expressed as the percentage of lung area with a attenuation of –200 to –700HU to the total lung volume (LAA–200––700%), quantitative indicators of pulmonary vascular include aortic diameter (AD), pulmonary artery diameter (PAD), the ratio of PAD to AD (PAD/AD ratio), the number of blood vessels (TNV), and the cross area of blood vessels (TAV). The receiver operating characteristic (ROC) curve is used to evaluate the ability of these indexes in identifying the changes in the lung in RA patients. RESULTS: Compared to the control group, the RA group has significantly lower TLV, larger AD, and smaller TNV and TAV (3921±1101 vs. 4490±1046, 33.26±4.20 vs. 32.95±3.76, 13.14±4.93 vs. 17.53±3.34, and 96.89±40.62 vs. 163.32±34.97, respectively, with all p < 0.001). Peripheral vascular indicator TAV has the better ability to identify lung changes in RA patients (area under ROC curve AUC = 0.894) than TNV (AUC = 0.780) or LAA–200 &sim–700% (AUC = 0.705). CONCLUSION: Quantitative CT can detect changes in lung density distribution and peripheral vascular injury in patients with RA and assess the severity.
Molecular Identification of I-3 gene, a Fusarium wilt resistant marker in selected varieties of tomato
Authors: Mahmood Tariq , Aziz Nobia , Inamullah  , Azizuddin  , M. Abbasi Fida , Ali Hamid , Shah Hussain
Published: February 2023

Fusarium wilt is a famous disease of tomato all over the world. The use of resistant varieties is the most efficient approach to control the disease. The current study was carried out to investigate the presence of marker gene(s) resistant to Fusarium wilt in tomato germplasm, and the subsequent use of resistant varieties to contain the disease. Thirteen varieties: Pusa ruby, Pant bahar, Punjab chhahara, Arka alak, Arak abha, Ratan, CLN-2116-B, CLN-1767-238-2Y, CLSN-2123-A, CLN-1621-E, CLN-1621-T, CLN-1621-L, and CLN-2026-C were screened for the presence of I-3 resistance gene, a marker known to confer resistance to the race 2 of F. oxysporum f. sp. Lycopersici. Two varieties, Arak abha and Ratan were tested positive for the presence of I-3 against the race 2 of the pathogen.
EXPRESSION OF GENES INVOLVED IN P53 PATHWAY REGULATION IN NEUROBLASTOMA: A SHORT REVIEW
Authors: Inomistova M. , Klymniuk H. , Khranovska N. , Pavlyk S. , Shaida E. , Gorbach O. , Skachkova O. , Shymon D.
Published: February 2023

The search for new prognostic and stratification genetic and epigenetic markers in neuroblastoma is an urgent problem in pediatric oncology. The review summarizes recent progress in studying the expression of genes involved in p53 pathway regulation in neuroblastoma. Several markers associated with recurrence risk and poor outcome are considered. Among them are MYCN amplification, high MDM2 and GSTP1 expression and homozygous mutant allele variant of GSTP1 gene A313G polymorphism. Prognostic criteria for neuroblastoma based on the analysis of miR-34a, miR-137, miR-380-5p, and miR-885-5p expression involved in regulating p53-mediated pathway are also considered. The authors’ research data on the role of the above markers in regulation of this pathway in neuroblastoma are presented. The study of alterations in expression of microRNAs and genes involved in p53 pathway regulation will not only expand our understanding of the mechanisms of neuroblastoma pathogenesis but could substantiate new approaches for delineating risk groups and risk stratification of neuroblastoma patients as well as treatment optimization based on the genetic characteristics of the tumor.
The translation technique analysis of assertive speech acts in Venom movie subtitles
Authors: Sagitasari Devy
Published: February 2023

The objective of this study is to find out the translation techniques in assertive speech acts of Venom movie subtitles by professional and amateur translators. The researchers used the qualitative method in analyzing the selected assertive speech acts data which are taken from the script and classifying them according to Searle (1969) theory, then classify the translation techniques according to Molina and Albir (2002) theory. The findings showed there are 144 utterances (data) of assertive speech acts. The total of single assertive speech acts is 136 (0.9%) utterances, the total of couplet assertive speech acts is 7 (0.06%) utterances, the total of single translation technique by the professional translator is 36 (0.39%) utterances, the total of single translation techniques by the amateur translator is 65 (0.43%) utterances, the total of couplet translation technique by the professional translator is 62 (0.44%) utterances, the total of duplet translation technique by the amateur translator is 56 (0.41%) utterances, the total of triplet translation techniques by the professional translator is 23 (0.21%) utterances, the total of triplet translation techniques by the amateur translator is 19 (0.18%) utterances, the total of quadruplet translation techniques by the professional translator is 3 (0.03%) utterances, the total of quadruplet translation techniques by the amateur translator is 3 (0.03%) utterances. Hopefully, this research is helpful for the future researcher, especially those who deal with the translating skill

Keywords: Translation; Translation techniques; Assertive speech acts; Subtitle
Blended learning strategy for engineering students in EFL class: Adoption of varied ranges of delivery procedures
Authors: Wardhani Norita Prasetya
Published: February 2023

COVID-19 Pandemic compels the teaching-learning strategy using remote learning to make the process of studying run well, including in Institut Teknologi Adhi Tama Surabaya, ITATS. A blended learning process could be applied to help the teaching-learning process. Before Covid-19 Pandemic spread in Surabaya, the students experienced fully face-to-face interaction in class. After COVID-19 existed in Surabaya, the students use the online learning process in the same semester. The highlight of this research is the case of the study which was related to the students in the teaching-learning process using blended learning in EFL class and explaining the ways how to teach and learn engineering students using blended learning. Descriptive quantitative was used to analyze the data. The data took from students' test and survey. Many students were getting difficulty in the implementation of blended learning using face-to-face strategy and google classroom. The students were allowed to access information from YouTube to make them easier to understand the materials. The lecturer was also explaining using google meet to have direct communication with the students was able to boost students’ knowledge of English materials. Adopting varied ranges of delivery procedures such as discussing was effectively boost the students' experiences and participation. Yet, those varied strategies are still ineffective rather than applying face-to-face class.

Keywords: Blended-learning; online learning: learning strategies
The achievement of students often taking selfies of the eleventh-grade students at SMKS Perwari Tulungagung
Authors: Nugrahini Yulia
Published: February 2023

In this study, the researcher wanted to prove whether the students who often take selfies get lower achievement than the students who do not often take a selfie at SMKS Perwari Tulungagung in the 2020/2021 academic year. The researcher used an ex-post-facto experimental design that was categorized into quantitative research. This study was conducted at SMKS Perwari Tulungagung. The population of this study was all students of eleventh grade at SMKS Perwari Tulungagung in the 2020/2021 academic year which consist of 320 students and the sample was taken randomly 15% about 48 students. The finding of this study can be seen that the average score of the experimental group was 84 and the control group was 85. It means that the experimental group got a lower score than the control group. Then, after the researcher analyzed the data by using the t-test formula, the researcher got the result t count was 2.557 by a significant level of 0.05 and df= n-2 = 48-2=46, and the t table is 2.013. Finally, it proved that the students who often took selfies got lower achievements than the students who did not often take a selfie on the students' achievement at SMKS Perwari Tulungagung in the 2020/2021 academic year.

Key Words: Taking selfies; achievements;
The Effectiveness of Cognitive-Behavioral Therapy based on Mindfulness of Psychological Distress and Tolerance of Ambiguity on COVID-19 Obsession Disorder
Authors:   School of Humanities, Tarbiat Modares University, Tehran, Iran, Sheykhangafshe Farzin Bagheri , Farahani Hojjatollah ,   School of Humanities, Tarbiat Modares University, Tehran, Iran, Fathi-Ashtiani Ali ,   Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Published: February 2023

Background: A high incidence of obsessive behaviors has been reported during the COVID-19 pandemic. Objective: This study was carried out to estimate the effectiveness of cognitive-behavioral therapy based on mindfulness of psychological distress and tolerance of ambiguity in patients with COVID-19 obsession . Materials and Methods: The present pretest-posttest study with a control group design was conducted on patients with COVID-19 obsession in 2021. The required information was collected using the COVID-19 obsession scale, a short form of psychological distress, and a tolerance of ambiguity questionnaire. The experimental group obtained ten 90-minute classes of cognitive-behavioral therapy based on mindfulness. The adjusted post-test scores were compared using an analysis of covariance. Results: The mean age of participants in the experimental and control group was 31.84 (standard deviation (SD)=4.68) and 34.09 (SD=7.05) years, respectively. Cognitive-behavioral therapy based on mindfulness significantly reduced anxiety (F=41.99, P=0.001, η2=0.63), depression (F=27.19, P=0.001, η2=0.53), stress (F=26.92, P=0.001, η2=0.52), and increases tolerance of ambiguity (F=31.63, P=0.001, η2=0.57), in patients with COVID-19 obsession disorder. Conclusion: The findings indicated that cognitive-behavioral therapy based on mindfulness appreciably improves the mental health of sufferers with COVID-19 obsession. Considering the long-term effects of COVID-19, psychology and counseling facilities should take measures to become aware of and treat vulnerable groups.
The Effectiveness of Strengths-Based Treatments for Impulsivity and Self-control in Adolescents with Binge-Eating Disorders
Authors:   School of Social Sciences, Hormozgan University, Hormozgan, Iran, Abazar fard Sabah , Javidan Lale ,   Department of psychology, School of Psychology and Social Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran, Meftahi Alireza ,   Department of psychology, School of humanity, Borujerd Branch, Islamic Azad University, Borujerd, Iran, Dabiri Taraneh ,   School of Social Sciences, Imam Khomeini International University, Qazvin, Iran, Solgi Zahra ,   Department of Psychology, Payame Noor University, Tehran, Iran
Published: February 2023

Background: There are various educational programs based on theoretical frameworks for binge-eating disorders. However, there is no evidence for Strengths-Based approach targeting low inhibitory control and impulsivity of the patients. Objectives: This experimental study explored the effect of a Strengths-Based clinical teaching course on impulsivity and self-control of adolescents with binge-eating disorder. Materials & Methods: The study was a quasi-experimental design with pre-test and posttest evaluations on adolescents with binge-eating disorders in clinical psychology in Kermanshah. A total of 26 adolescents with binge-eating disorders were randomly assigned to the experimental (n=13) and control (n=13) groups. Then, they were asked to fill out a questionnaire about Barrat’s impulsivity scale and Tangney’s Self-Control Scale. The experimental group was taught methods and techniques of strengths-based strategies for eight 90-minute sessions followed by training sessions of strengths-based skills once a week for 2 months, whereas the control group received no psychological training during this time. After these sessions, both groups were given post-test evaluations. Data were compared using multivariate and univariate analysis of variance. Results: The age range of participants was 14-18 years. The mean post-test score showed that impulsivity was significantly decreased and self-control was significantly increased in the experimental group. The result of univariate analysis of variance indicate that the two groups differed significantly on impulsivity (F=15.91, P=0.001,ηp2=0.59) and self-control (F=17.25, P=0.001, ηp2=0.62). Conclusion: Using a strength approach offers effective self-control and impulsivity to adolescents with binge-eating disorders.
Self-harming Behaviors and suicide probability in delinquent adolescent girls: The role of emotion dysregulation and modeling the self-harming of peers
Authors:   Department of Psychology, Torbat jaam Branch,Islamic Azad University, Torbat jaam, Iran, Akbari-Motlaq Maryam , Teymuri Saied ,   Department of Psychology, Torbat jaam Branch,Islamic Azad University, Torbat jaam, Iran, Asghari-ebrahimabadi Mohammadjavad ,   Department of Psychology, , Ferdowsi University of Mashhad, Mashhad, Iran, Mahram Behrouz ,   Department of Psychology, , Ferdowsi University of Mashhad, Mashhad, Iran
Published: February 2023

Background: Adolescents may be exposed to several mental health related difficulties due to lack of complete cognitive maturity. Objective: This study investigated the mediation of emotion dysregulation and modeling of peers in relation between self-harming behaviors and suicide probability in adolescent. Material& Methods: In a descriptive study, we investigated juvenile delinquents of Correction and Rehabilitation Center of Mashhad during 2021. A total of 148 individuals were selected and evaluated using the self-harm motivation scale, Ottawa self-harming inventory, regulation problems scale and peer self-harm modeling scale. Data were analyzed using structural equation modeling in SmartPLS-3 software. Results: The mean age of participants was 16.21 (standard deviation=2.42). There was significant direct effect of self-harming behaviors on suicide probability (β=0.86 , P= 0.001 ). The significant indirect effect of self-harming behaviors on suicide probability through emotional dysregulation (β= 0.36, P= 0.001 ) was stronger than indirect effect mediated by peers modeling (β=0.17 , P= 0.04 ). The model account for 87 % of total variance of suicide probability. Conclusion: Based on the findings of the study, it can be concluded that emotion dysregulation and peers modeling play a role in increasing suicide probability and should be considered in preventing harmful behaviors in adolescents.
Placebo-controlled Trial of Oral Vitamin D and Alendronate Efficacy for Pain and Modic Changes in Lumbar Fusion Surgery
Authors:   Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran, Haddadi Kaveh , Mehriyari Mahmoud ,   Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, Ehteshami Saeed ,   Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran, Shafiee Sajjad ,   Neurosurgery Department, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran, Ghasemi Ahmad ,   Department of Radiology, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran, Asadian Leila ,   Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, Aarabi Mohsen ,   Azad University (IR) in Oxford, Oxford, UK AND Department of Family Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Published: February 2023

Background and Aim: Modic changes are alterations in the spine endplates and subchondral bone shock absorption, seen by magnetic resonance imaging (MRI). No studies have investigated the effect of vitamin D and alendronate as oral drugs on reducing and modifying Modic changes after degenerative spine fusion surgery. This study aimed to evaluate the efficacy of oral vitamin D and alendronate administration in patients with low back pain, and Modic changes undergoing lumbar fusion surgery. Methods and Materials/Patients: A total of 81 middle age women with a normal range of serum vitamin d were enrolled in three groups who underwent lumbar fusion surgery according to neurosurgical criteria. Group 1 (n=27) received additional oral alendronate, group 2 (n=27) received oral vitamin D for six months postoperatively, and group 3 (n=27) received no drug (except simple analgesics and antibiotics). The patients were followed up with a visual analog scale (VAS) and Oswestry disability index (ODI). MRI was done before and six months after surgery. Results: There was no significant difference between the three groups in VAS and ODI scores (P=0.416, P=0.601, respectively), but the mean VAS and ODI in all three groups decreased over six months, which was statistically significant (P<0.001). Modic changes in all three groups changed significantly over 6 months (P<0.01). In the vitamin D and alendronate groups, Modic type 3 increased significantly, but Modic type 2 and Modic type 1 decreased significantly in the vitamin d and no medication groups, respectively. Conclusion: Oral vitamin D administration has a desirable effect not only on clinical outcomes after lumbar spinal fusion surgery because of degenerative surgery but also on vertebral endplate Modic changes compared to oral bisphosphonate.
Decompressive Cranioplasty Using Titanium Mesh in a Patient with Osteopetrosis: Case-based Reviews
Authors:   Department of Neurosurgery, Education and Research Hospital, University of Samsun, Samsun, Turkey, Demirel Cem , KÖKSAL Vaner ,   Department of Neurosurgery, Medical Faculty, University of Samsun, Samsun, Turkey
Published: February 2023

Background and Importance: Osteopetrosis is an inherited disease that causes the thickening of the cranial bone. The need for both cerebral decompression and intracranial volume-enlarging cranioplasty in the same surgical session in a patient suffering from rising intracranial pressure is critical and a very rare decision in neurosurgical practice. The only indication that can lead to this surgery is osteopetrosis. Case Presentation: A 24-year-old female patient with osteopetrosis was admitted with the complaint of severe headache that did not respond to medical treatment, and surgery was decided. After decompressive craniectomy was performed with difficulties, cranioplasty with titanium mesh was performed in the same session to protect the cerebral tissue, close the defect area, and give more space to the cerebral tissue. It was observed that the complaints of increased intracranial pressure were completely resolved in the early postoperative period and the one-year clinical follow-up. The surgical intervention technique and the radiological findings obtained during the follow-up are presented. Conclusion: Performing cranioplasty with titanium mesh, which is used to protect and save cerebral tissue in patients with osteopetrosis, seems the most appropriate choice.
Effectiveness of emotional-social skills traning in psychological distress and social isolation by moderating the coping styles in symptoms of depressed adolescents
Authors:   MSc, Department of Psychology, University of Tabriz, Tabriz, Iran, Mardoukhi Dana , Hashemi Touraj ,   Professor, Department of Psychology, University of Tabriz, Tabriz, Iran., Khanjani Zaynab ,   Professor, Department of Psychology, University of Tabriz, Tabriz, Iran.
Published: February 2023

Introduction: Depressive disorder is associated with various consequences such as psychological distress and social isolation, whichtheir removing is of importance. Aim: The present study was conducted with the aim of determining the effectiveness of socialemotional skills training on psychological disturbance and social isolation in adolescents with depressive symptoms by modulating coping styles. Method: This research is a semi-experimental type. Its statistical population was formed by male students suffering from depression disorder in Baneh city with an age range of 16-18 years in 2020. 30 students were targeted and screening method selected as a statistical sample based on the results of the Lazarus and Folkman coping styles scale and divided into two groups of 15 people (excitement-oriented and problem-oriented) were divided. The questionnaires used in this research included Beck Depression Questionnaire and Depression, Anxiety and Stress Questionnaire and Social Isolation Questionnaire. SPSS version 20 software and multivariate covariance analysis were used for data analysis. Results: The results of data analysis using multivariate analysis of covariance showed that social-emotional skills training was effective in improving psychological disturbance and social isolation. Also, coping styles moderate the effect of social-emotional skills training in psychological disturbance and signs of social isolation (P<0.05). Conclusion: The findings of this study showed that teaching emotional and social skills to adolescents with symptoms of depression was useful and reduces psychological disturbance and social isolation, and the type of coping styles was also effective in these changes. It is suggested to include social-emotional skills training in the treatment program of adolescents with depression.
Recovering from Post-Traumatic Stress Disorder symptoms: A study on the combination of art and mindfulness
Authors:   Associate Professor, Department of Clinical Psychology, Kermanshah University of Medical Sciences, Kermanshah, Iran., Sadeghi Kheirollah , Goodarzi Golfam ,   MSc, Department of Clinical Psychology, Kermanshah University of Medical Sciences, Kermanshah, Iran, Foroughi Aliakbar ,   Assistant Professor, Department of Clinical Psychology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Published: February 2023

Introduction: Even though sexual assault is rarely considered a serious social problem; it can lead to severe mental-health consequences. Aim: The aim of the current study was to assess the attrition rates and the effectiveness of a therapeutic program of art and mindfulness on Post-Traumatic Stress Disorder (PTSD) in female sexual assault survivors. Method: This study was a controlled clinical trial with a design of pre-test, post-test, and a twomonth follow-up. The population included women with sexual assault experience that had sought professional help in the psychotherapy clinics of Hamedan in 2019. 16 individuals were first selected using purposive sampling and then were allocated randomly to control (N=8) and experimental groups (N=8). The utilized questionnaires included the Impact-of-Event-Scale (2007) and the Depression-Anxiety-Stress-Scale-21 (1995). The combined treatment of art and mindfulness was conducted for the experimental group through eight two-hour weekly sessions. The data were analyzed using descriptive and inferential statistics, one-way ANCOVA and SPSS software-version 22. Results: Findings indicated that the combined art and mindfulness therapeutic program reduced intrusion (F=20.34, P<0.001), arousal (F=20.43, P<0.001), avoidance (F=14.32, P<0.002), and stress scores (F=33.46, P<0.001) significantly in the experimental group. Conclusion: The findings indicated that the combined art therapy and mindfulness method could play a significant role in the alleviation of PTSD symptoms in sexually traumatized individuals. It is suggested that the therapists consider this intervention for individuals that are severely afraid of their trauma-related memories.
Effectiveness of mindfulness therapy in reducing rumination, perceived stress and feelings of loneliness in women with Multiple Sclerosis (MS)
Authors:   PhD Student, Department of Psychology, Ilam Branch, Islamic Azad University, Ilam, Iran., Soltani Shirin , Mami Shahram ,   Assistant Professor, Department of Psychology, Ilam Branch, Islamic Azad University, Ilam, Iran, Ahmadi Vahid ,   Assistant Professor, Department of Psychology, Ilam Branch, Islamic Azad University, Ilam, Iran., Mohammadzadeh Jahanshah ,   Associate Professor, Department of Management, Ilam University, Ilam, Iran.
Published: February 2023

Introduction: Multiple sclerosis is a disorder of the nervous system that causes many physical and mental changes in a person. Aim: The present study investigated the effectiveness of mindfulness therapy in improving rumination, perceived stress, and loneliness in women with multiple sclerosis. Method: This was a clinical trial with pre-tests, post-tests, and follow-ups with a control group. All women aged 20 to 40 who referred to the MS Association of Sanandaj in the spring and summer of 2019 were included in the study. We randomly divided 40 women with MS into two experimental and control groups based on available sampling. Based on available sampling, we randomly divided 40 women with MS into two experimental and control groups. Research tools included Nolen Hoeksma and Maro (1991) Rumination Response Scales, Cohen's (1983) Perceived Stress Questionnaire, and Russell et al.'s (1978) California Loneliness Questionnaire. The data were analyzed using analysis of covariance with the help of SPSS version 24 software. Results: The findings showed that mindfulness-based therapy was effective in improving the amount of rumination, perceived stress, and loneliness in both the post-test and follow-up phases in the experimental group (P<0.05). Conclusion: Mindfulness-based therapy is an effective method in improving rumination, perceived stress, and feelings of loneliness in people with MS. It was MS, so it is suggested to be used in the treatment of people with MS.