bluuebunny/crossref_metadata_2025 huggingface dataset:
أثر تمرينات مهارية في تطوير بعض المهارات الهجومية المنتهية بالتصويب السلمي للاعبي كرة السلة تحت18 سنة
Authors: Asst. Lect. Mustafa Fadel Khader
Published: September 2024

تمثلت أهمية البحث في اعداد تمرينات مهارية تكون مشابهة لمواقف اللعب ليتم من خلالها  العمل على تطوير المهارات الهجومية المنتهية بالتصويب السلمي كون هذا النوع من التصويب يكون هو الأكثر استخداماً من قبل اللاعبين في المباريات اما مشكلة البحث فقد تبلورت في وجود ضعف  لدى لاعبين كرة السلة ( تحت 18 سنة) في المهارات الهجومية المنتهية بالتصويب السلمي التي يحتاجها اللاعب للارتقاء بمستواه المهاري في كرة السلة وخاصة في المواقف التي يكون فيها اللاعبين المهاجمين مراقبين بشكل جيد من قبل اللاعبين المدافعين مما يؤدي الى صعوبة انهاء الهجمات بدقة مالم يكن لدى اللاعبين المهاجمين المستوى المهاري الذي يؤهلهم للإنهاء الصحيح لهذا النوع من التصويب، وخصوصاً فئة الشباب التي تكون فيها خصوصية دقيقة كون اللاعب في مرحلة مهمة للانتقال الى مرحلة المتقدمين.
وهدف البحث الى:
1- إعداد تمرينات مهارية في تطوير بعض المهارات الهجومية المنتهية بالتصويب السلمي للآعبي كرة السلة (تحت 18سنة).
2- التعرف على تأثير التمرينات المهارية في تطوير بعض المهارات الهجومية المنتهية بالتصويب السلمي للآعبي كرة السلة (تحت 18سنة).
وفرض البحث هو:- -للتمرينات المهارية أثراً في تطوير المهارات الهجومية المنتهية بالتصويب السلمي للآعبين (تحت 18 سنة).
أما أهم الاستنتاجات:
-فاعلية التمرينات المهارية المستخدمة في الدراسة في تطوير المهارات الهجومية المنتهية بالتصويب السلمي.
التوصيات:
1-الإهتمام بتدريب اللاعبين على المهارات الهجومية المنتهية بالتصويب السلمي بمواقف تدريبية تكون مشابهة لمواقف اللعب في المباريات.
A Systematic Review and Illustrative Case of Post- Decompressive Craniectomy Syndrome Following Traumatic Brain Injury
Authors: Permana Khrisna Rangga , Agus Turchan  , Tedy Apriawan  , Joni Wahyuhadi  , Abdul Hafid Bajamal  , Heri Subianto
Published: September 2024

Post-decompressive craniectomy syndrome (PDCS) is a complication following decompressive craniectomy (DC). PDCS or also known as trephine or sunken skin flap syndrome has an indirect relationship with traumatic brain injury (TBI). The mechanism of PDCS is not yet fully understood and the clinical manifestations are diverse, causing PDCS to often be underdiagnosed. In this study, the authors aim to create a systematic review of PDCS following TBI including a discussion of incidence, clinical and radiological manifestations, management and outcome. This systematic review is conducted based on the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline. The literature search included electronic databases PubMed, Cochrane, JNS and EMBASE. All studies included were available in English and full-text format. In this research, 42 case reports were obtained. The population was predominantly male (72%) with a mean population age of 44.7 ± 17.3 years. The mean interval for onset and cranioplasty procedure was 80.17 ± 77.34 days and 92.05 ± 77.06, respectively. The most common clinical manifestations were sunken skin flap in the defect area (74%) and decreased consciousness (64%). Paradoxical herniation (74%) was the most common radiological manifestation. There was no connection between the occurrence of PDCS and the size of the defect. Cranioplasty remains the mainstay of management with clinical improvement in 96% of cases. PDCS should be suspected in every patient with symptoms of new neurological deficits after DC. Early management must be carried out to prevent further deterioration.
Development and Evaluation of the DMIND Questionnaire: Preparing for AI Integration into an Effective Depression Screening Tool
Authors: Hemrungrojn Solaphat , Saengsai Kittipoch , Jakkrawankult Pasit , Kiattiporn-Opas Chanyanart , Chaichareenon Kantapat , Amrapala Arisara , Lapanan Kulvara , Hengprapom Sarunya , Hiransuthikul Narin , Achakulvisut Titipat , Nupairoj Natawut , Phutrakool Phanupong , Yodlorchai Rapinpat , Vateekul Peerapol
Published: September 2024

Objective: Thailand’s mental health crisis is exacerbated by high demand and a shortage of mental health professionals. The research objective was to develop and validate the Detection and Monitoring Intelligence Network for Depression (DMIND) questionnaire, designed to be culturally relevant and easily administered in clinical settings. Crafted with expert input, items specifically conducive to artificial intelligence (AI) analysis were selected to facilitate the future development of an AI-assisted depression scoring model. This approach underscores the tool’s dual utility in both human-led and technology-enhanced diagnostics.
Materials and Methods: We enrolled 81 participants from psychiatric and tertiary care hospitals in Bangkok. Participants were assessed using the DMIND questionnaire, followed by the Hamilton Depression Rating Scale (HDRS-17). Statistical analyses included the content validity index (CVI), Cronbach’s alpha, Pearson’s correlation coefficient, Cohen’s kappa, and receiver operating characteristic (ROC) analysis. The Liu method, Youden index, and nearest neighbor method were used to determine the optimal cut-off point
Results: The DMIND questionnaire showed strong validity, with an item-level CVI (I-CVI) and scale-level CVI (S-CVI) exceeding 1.0, indicating strong consensus on its relevance and utility. The tool also demonstrated high internal consistency (Cronbach’s alpha = 0.96). ROC analysis showed an AUC of 0.88, indicating high accuracy in depression screening. An optimal cut-off score of 11.5 was identified, balancing predictive value and sensitivity.
Conclusion: The DMIND questionnaire represents a significant advancement in innovative mental health diagnostics, addressing unmet clinical needs by providing accurate and efficient assessments capable of AI integration for further enhancing mental health service delivery in Thailand.
Revolutionizing the Digital Creative Industries: The Role of Artificial Intelligence in Integration, Development, and Innovation
Authors: Wagan Shah Mehmood , Sidra Sidra
Published: September 2024

Purpose - Artificial intelligence is profoundly transforming the digital creative industry, becoming a key force in industrial upgrading through technology integration, innovation drive and productivity improvement. Methods- This study uses a variety of methods, including literature review, questionnaire survey, in-depth interview and data analysis, to systematically examine the application effect of AI in the digital creative industry. The structural equation model is used to verify the hypothesized relationship, and the role of AI in promoting industrial integration, development results and innovation catalysis effect are comprehensively analyzed. Research results- The research that AI importantly promotes technological integration, development and innovation inside the digital creative industry, and improves the general overall performance of the industry. The path coefficient is incredibly substantial, and the model fit is good, which verifies the effective position of AI in industrial integration and development. The position of AI not only improves the competitiveness of the industry, but also provides robust support for the personalization and excessive quality of creative products. Originality- This paper demonstrates remarkable originality in theoretical framework construction, empirical data analysis, and exploration of practical challenges and this paper deeply analyzes the multiple mechanisms of AI in the digital creative industry, providing new ideas and specific quantitative evidence for research in related fields. Implications - Practitioners need to actively accept AI era, optimize creative workflows, and enhance production efficiency and constantly enhance their digital talents and cross-area information integration capabilities. Policymakers should formulate focused support policies to promote the vast application and deep integration of AI technologies inside the creative industries.
Synthetic Colorants in Traditional Sweetmeat (Laddu) available in Dhaka City, Bangladesh
Authors: Roy Shatabdi , Saroar Forkan , Islam Md Mazharul , Nahar Nilufar , Shoeb Mohammad
Published: September 2024

Laddus are very popular sweets all over the South Asian countries including Bangladesh. Commercially accessible sweets (Laddus) contain a variety of Yellow 5 and Yellow 6 dyes, which are hazardous when consumed in excess. In this study, the amount of Yellow 5 and Yellow 6 in twenty-five Yellow-colored Laddus from various sweet shops in Dhaka, Bangladesh, was determined using a UV-visible spectrophotometer at 425 and 482 nm, respectively. Quantification was done using external calibration curves of the standard Yellow 5 and Yellow 6 and the calibration curves showed excellent linear correlation co-efficient (R2) of 0.999 and 0.998 for them, respectively. Of the twenty-five samples, eleven had Yellow 5 in the range of 0.915-6.790 mgkg-1, and eight had Yellow 6 in the range of 0.223-4.315 mgkg-1. The rest of the samples did not contain any Yellow 6 as well as Yellow 5.
Dhaka Univ. J. Sci. 72(2): 45-51, 2024 (July)
Identifying Factors Associated with Health Problems of Tannery Workers, Savar, Dhaka
Authors: Oyshi Nadia Mehjabeen , Rafi Amirul Al , Karami Md Jamil Hasan
Published: September 2024

This research investigates the incidence and patterns of health problems experienced by tannery employees, as well as the associations between such problems and a variety of other variables. The cross-sectional study was conducted at three randomly selected tanneries of the BSCIC Tannery Industrial Estate in Savar. During in-person interviews, 203 workers were questioned using a questionnaire. Most respondents (84.2%) admitted that they had health problems caused by their jobs. Musculoskeletal disease (65.5%), gastrointestinal problems (38.9%), skin disease (37.9%), respiratory disease (26.6%), and eye disease (17.7%) were the significant causes of illness. Our research revealed that factors such as respondents' age (p value=.001), experience (p value<.000), working hours (p value=.005), mode of work (p value=.044), types of PPE (p value=.017), and awareness of toxic chemical rules (p value=.033) were significantly associated with health problems among tannery workers. A healthy tannery environment and enhanced medical facilities may improve their health.
Dhaka Univ. J. Sci. 72(2): 68-74, 2024 (July)
La máscara del alacrán
Authors:   Universidad Central, Castro-Rodas Juan Pablo
Published: September 2024

En la turbia noche quiteña, alguien ha matado al doctor Alfonso García Brito, un viejo coleccionista de arte, de gustos decadentes y perversos. El teniente Veintimilla -El singular detective y dandy creado por Juan Pablo Castro Rodas-, atraviesa las calles de la ciudad en su anacrónico Mercury a la búsqueda del asesino, mientras el país amenaza con desintegrarse sometido a la demencial violencia del crimen organizado. Sobre este sórdido telón de fondo, el autor teje una inquietante trama policial que recorre distintos parajes y estratos sociales de una capital cartografiada con maniática precisión: desdelas altas esferas a los ambientes marginales en los que el protagonista encuentra criaturas dueñas de una belleza cinematográfica y peligrosa, habitantes naturales del mal: María Dolores, Marilyn, Clarice/Justine, y el mismísimo Alacrán, siniestro y hermoso como un James Dean del submundo. Con una escritura morosa, que se solaza en los pormenores físicos del paisaje o del cuerpo, en su afán por construir atmósferas vívidas y extrañas, piscologías complejas y moralmente ambiguas, Castro Rodas nos regala una ficción que es un tributo a la novela negra y, particularmente, a uno de sus personajes capitales: el Philip Marlowe de Raymond Chandler. En esta ficción plagada de guiños y alusiones literarias y culturales, incluso el objeto del delito es construido como una detallista cita a la pintura, es decir, como una obra de arte. 174 páginas ISBN: 978-9942-670-06-9 e-ISBN: 978-9942-670-07-6
Cardiovascular Risk, Statin Use and Electrocardiogram in HIV Patients
Authors: Barbosa Roberto Ramos , Pimenta Suzano Ana Luísa , Torres Beatriz Castro , Andreão Carolina Rios , de Barros Lucas Crespo , Sylvestre Rodolfo Costa , Figueira Camila Magioni , Uliana Ramona Dutra , Oliveira Santos Carolina Rocio , Machado Barbosa Luiz Fernando
Published: September 2024

Introduction: Non-infectious complications became more frequent in patients living with the Human Immunodeficiency Virus (HIV). Dyslipidemia is common and represents an important cardiovascular risk factor in this population. Therefore, cardiovascular diseases represent one of the main causes of HIV morbidity and mortality. Objective: This study aimed to assess cardiovascular risk and electrocardiographic changes in outpatients living with HIV. Methods: We performed a single-center cross-sectional study that included HIV patients who were at least 30 years old and had HIV diagnosis for more than one year. Patients were on regular follow-up in a tertiary center in Brazil. Cardiovascular risk was assessed using the Global Risk Score (GRS), as recommended by Brazilian guidelines. Cardiovascular risk factors, lipid profile, statin use and resting electrocardiogram were also analyzed. Results: 92 patients were included, with an average age of 48.9 years. 54 (58.7%) were male, 28 (30.4%) had hypertension, 10 (10.9%) had type 2 diabetes mellitus, 9 (9.8%) were current smokers, and 25 (27.2%) had a previous diagnosis of dyslipidemia. Average LDL-cholesterol level was 120.2 ± 40.6 mg/dl. Eleven patients (11.9%) were on statin therapy. High cardiovascular risk was identified in 28 patients (30.4%) and only seven of those (25.0%) were on statin therapy. Serum LDL-cholesterol higher than or equal to 130 mg/dl was found in 31 patients (33.7%), and only seven of those (22.6%) were on statin therapy. ECG changes were found in 21.7%, mostly due to conduction disturbances (17.4%). Conclusion: We found a high prevalence of HIV outpatients with high cardiovascular risk. Only one in every four patients with this characteristic was on statin therapy. Cardiovascular risk is one of the main concerns in the HIV population, once antiretroviral therapy succeeds to reduce mortality attributed to opportunistic infections.
EKSPLORASI DINAMIKA PEMBELAJARAN: INOVASI, TANTANGAN, DAN SOLUSI DALAM PENGEMBANGAN KURIKULUM BAHASA ARAB DI MI SUNAN GIRI MALANG
Authors: Mustaufir  , Abdillah Muhammad , Hasanah Mahmudatul
Published: September 2024

Penelitian ini mengeksplorasi dinamika pengajaran bahasa Arab di SD Sunan Giri Malang dengan fokus pada inovasi, tantangan dan solusi dalam pengembangan kurikulum. Pendidikan bahasa Arab menghadapi tuntutan era globalisasi dan kemajuan teknologi, yang memerlukan inovasi kurikulum untuk memenuhi kebutuhan zaman. Penelitian bertujuan untuk mendeskripsikan inovasi implementasi kurikulum dan mengidentifikasi tantangan serta solusi dalam konteks SD Sunan Giri. Metodologi kualitatif dengan wawancara digunakan sebagai teknik pengumpulan data. Guru bahasa Arab di SD Sunan Giri menjadi responden dan data dianalisis secara kualitatif. Hasil penelitian menunjukkan bahwa penerapan kurikulum bahasa Arab di sekolah sudah menunjukkan kemajuan, namun masih terdapat tantangan seperti persepsi kesulitan bahasa Arab oleh siswa.
FA’ALIYATU AN NASYATHOTI AL LUGHOWIYATI KULLA SHOBAHI FI TARQIYATI MAHAROTI AL KALAMI
Authors: Arisandi Yusuf , Cemerlang Ahmad Abdan
Published: September 2024

ABSTRAK
Keterampilan berbicara dianggap sebagai bagian utama dari kurikulum pengajaran bahasa asing. Ini adalah keterampilan produktif yang mengharuskan pelajar untuk dapat menggunakan suara secara akurat, dan menguasai bentuk tata bahasa dan sistem pengurutan kata yang membantunya mengungkapkan apa yang ingin ia katakan dalam situasi percakapan. Sayangnya, siswa yang tidak berbahasa Arab merasa kesulitan dalam berbicara dan memahami teks, terutama dalam pengucapan huruf yang benar. Permasalahan lain yang peneliti temukan adalah metode pengajaran yang digunakan guru membosankan sehingga membuat siswa merasa bosan dalam belajar. Penelitian ini berfokus pada kegiatan linguistik untuk meningkatkan keterampilan berbicara santri pondok pesantren Al-Huda dan mengetahui efektifitas kegiatan berbahasa di pondok pesantren Al-Huda Bawyan.
Metode penelitian eksperimen ini menggunakan pre-and post-test untuk kelompok kontrol dan kelompok eksperimen. Pendekatan yang digunakan adalah pendekatan kuantitatif. Alat pengumpulan data dalam penelitian ini adalah: observasi, wawancara, dan tes. Hasil penelitian menunjukkan bahwa efektivitas seluruh aktivitas linguistik dalam meningkatkan keterampilan berbicara santri pondok pesantren Al-Huda Bawyan Jawa Timur adalah efektif. Kegiatan linguistik setiap pagi membuat siswa merasa bersemangat dan mudah dalam meningkatkan keterampilan berbicara serta kemudahan dalam menerapkan tuturan.
Kata Kunci: Aktivitas Linguistik, Keterampilan Berbicara
Acclimation capacity of Echinarachnius parma sand dollars enduring a highly seasonal sub-Arctic coastal system
Authors: Uboldi T , Bridier G , Olivier F , Grall J , Chauvaud L , Tremblay R
Published: September 2024

Marine poikilotherm organisms have evolved several physiological strategies to acclimate to different thermal conditions occurring in coastal environments. This study aimed to describe the acclimation capacity of sand dollars Echinarachnius parma found in the highly seasonal sub-Arctic archipelago of Saint Pierre and Miquelon. Fatty acid composition was quantified in cell membranes and energy reserve of sand dollars collected at specific stations according to depth and seasons. We hypothesized that perceived temperatures, seasonal thermal conditions and the trophic environment may considerably influence E. parma fatty acid profiles. In the polar fraction, E. parma showed high relative contributions of eicosapentaenoic acid (20:5ω3; 28.5%) followed by 16:0 (10.83%), 14:0 (6.67%) and 18:4ω3 (3.49%). Whereas variations in 20:5ω3 relative contributions seemed to be mainly related to spawning events, docosahexaenoic acid (22:6ω3; 2.48%) and arachidonic acid (20:4ω6; 2.49%) varied according to the thermal gradient of the water column. Furthermore, the seasonal thermal internal wave acting throughout the archipelago appeared to lack sufficient intensity to trigger modifications in the polar concentration in individuals. In the neutral fraction, the strong dominance of diatom markers (20:5ω3; 24.2% and 16:1ω7; 21.9%) suggests that the diet of sand dollars mostly reflects the composition of the organic matter available over the sediment. Our study (1) highlights specific fatty acid functions in the metabolic regulation of echinoids, (2) defines the feeding ecology of sand dollars and (3) describes the effects of different thermal conditions on the physiology of locally adapted poikilotherm animals.
Complexity in Simplicity: Unraveling the Heterogeneous Nature of Malignant Rhabdoid Tumors
Authors:   , Paassen Irene Evelyn Karla
Published: September 2024

In this thesis we study the heterogeneity seen within the childhood cancer: malignant rhabdoid tumors (MRTs). These tumores are defined solely by loss of SMARCB1, a gene which is part of the swi/snf complex. Although we can only identify this one single genetic driver event, several subgroups can be identified based on DNA methylation profiling as well as molecular characteristics. In the body they can occur either outside of the brain (extra-cranial MRTs) or in the brain called atypical teratoid rhabdoid tumors (ATRTs), which are subdivided into the subgroups MYC, SHH and TYR. In this thesis we investigated the differences between these subgroups on different levels. Firstly, we set out to establish new patient-derived organoid models from the ATRT-MYC and ATRT-SHH group and identified new subgroup-specific drug compounds via high throughput drug screens. Secondly, we looked into the different ways of how ecMRTs are genetically regulated and studied their chromatin organization finding patient-specific enhancer-promoter loops activating the MYC oncogene. And lastly, we studied the intertumoral differences on single cell RNA and ATAC level of the different ATRT subgroups.
Alternatives to animal research: from in vitro to ex vivo liver models
Authors:   , Krüger Melanie
Published: September 2024

Understanding the critical importance of reducing reliance on traditional research animal models in liver disease research, this thesis focused on advancing the development of more sophisticated, physiologically relevant, and ethically aligned models. These alternatives aimed to effectively simulate the complexities of liver disease, fostering the exploration of novel therapeutic strategies and a more comprehensive understanding of liver pathophysiology without compromising ethical standards.
In chapter 3, the study offered critical insights into the use of nanofibrillar cellulose as an effective scaffold material for tissue engineering, providing a viable alternative to animal-based models. By shedding light on the interplay between cellulase enzyme concentration, flow conditions, and fibroblast spheroid cultures within nanocellulose hydrogels, the research enhanced our understanding of the cell microenvironment and contributed to the advancement of ethical and effective alternatives to animal-based disease modeling.
Furthermore, chapter 4 addressed the pressing need for reliable and clinically applicable liver disease models. Through a systematic assessment of cellulose nanofibril hydrogels as a viable alternative to traditional Matrigel, the research presented a pathway for the development of more standardized and ethically sound liver disease models, fostering a more responsible approach to liver disease research and therapeutic development.
Chapter 5 represented a crucial step forward in the quest for advanced large-animal models that closely mimicked human liver physiology. By successfully generating and integrating porcine intrahepatic cholangiocyte organoids into porcine liver scaffolds, the research provided a promising animal-free platform for studying complex liver pathologies and advancing therapeutic interventions, ultimately reducing the reliance on traditional research animal models.
Lastly, chapter 6 introduced a practical and ethical alternative to animal-based studies, emphasizing the importance of developing comprehensive research alternatives. By accurately replicating biochemical markers of liver damage, the platform served as a promising solution for studying metabolic and toxic liver disorders without the need for traditional research animal models, contributing to the establishment of a more ethical and effective paradigm in liver disease research.
In conclusion, these endeavors mark significant progress in the field of liver tissue engineering and disease modeling, emphasizing the importance of advancing sophisticated and ethically aligned research alternatives. Through the development of these innovative models, the research not only furthers our understanding of liver disease mechanisms but also significantly contributes to the ongoing effort to reduce the dependence on traditional research animal models in liver disease research.
Investigating Wrinkle Resistance of Cotton and Cotton Blended Fabrics in Relation to a Non-Formaldehyde Durable Press Finish
Authors: Yu Ui-Jeen
Published: September 2024

This study investigated cotton fabric’s wrinkle resistance with a durable press finish, compared to 100% cotton and cotton blended fabrics. Wrinkle resistance of cotton fabrics can be achieved by using chemical resin finishes or blending with polyester, nylon, or spandex. Most of wrinkle resistance finishes contain harmful chemicals such as formaldehyde. However, a durable press finish through pad, dry, and cure fabric application process is treated with crosslinking resins, and it improves wrinkle resistance and is formaldehyde-free, making it a prime alternative to the wrinkle resistance finishes with formaldehyde. Eight different cotton and cotton-blended fabric samples were tested in relation to a non-formaldehyde durable press finish. The fabric samples were tested using AATCC 128 Wrinkle Recovery of Fabrics: Appearance Method. One-way between groups ANOVAs were conducted to examine how wrinkle resistance differs among the fabric samples, depending on fiber type, wrinkle resistant finishes, and non-formaldehyde durable press finish. Post-hoc comparisons using the Bonferroni test were also conducted. Results indicate that there were significant differences on wrinkle resistance by the different fiber contents and wrinkle resistance finishes. The 100% cotton fabric with the nonformaldehyde durable press finish showed greater wrinkle resistance than the other fabrics. The non-formaldehyde durable press finish also has other properties such as abrasion resistance, shape retention, pilling resistance, etc. Further research on these properties is needed to explore characteristics of the non-formaldehyde durable press finish, compared to other wrinkle resistant fabrics.
Exploring Apparel Design Students’ Willingness to Use Virtual Reality in the Sketching Phase of the Fashion Design Process
Authors: Binhajib Aseel H
Published: September 2024

Virtual reality (VR) is a computer-generated experience through projection of shapes, objects, and scenic views via headset or helmet device and interpreted as a genuine realistic environment. The interpretation of the highly realistic projection from the eye creates an immersive experience for the user. The use of VR technology is utilized in an array of industry applications as well as learning/training spaces. In particular, when VR is used in an educational setting, studies have shown positive or improved student achievement for a variety of academic disciplines in conjunction with creativity, inspiration, engagement, and motivation. VR used in industry applications, specifically within apparel industries, has been reported to enhance efficiencies in retail, enable virtual garment fitting, and reduction of physical samples in the apparel design and product development process. Regardless of these demonstrated favorable outcomes from education and industry, few research studies have investigated students’ willingness to adopt VR as a tool for use within their desired academic discipline (feeding into their future career path). As use in the apparel design and product development process has been reported, an opportunity exists to explore VR as an educational tool to ideate fashion design ideas in an individual’s apparel design process. Thus, the goal of this study was to provide initial insights into students’ willingness to use VR as a sketching tool, compared to traditional sketching tools, during the apparel design process. A multiple case study design was employed to examine the phenomenon in eight selected undergraduate Apparel Design students. The study was guided through the lens of the Unified Theory of Acceptance and Use of Technology (UTAUT) framework to examine students’ willingness based on performance expectancy, effort expectancy, social influence, and facilitating conditions to use VR. A learning module was developed in a 300-level apparel design course specifically to explore VR as a sketching tool in their design ideation process. Students received a demonstration for how to use the Oculus Quest VR equipment and experimentation/practice time using the equipment in conjunction with the Gravity Sketch (GS) VR application which allowed student users to draw in virtual space on an imported preexisting dress form. Following the practice time, students then completed an apparel design activity using the VR tool. Students then completed a survey in which data was collected through mixed methods by questionary scales and open-ended questions. The findings suggest a relationship between social willingness to adopt VR in their design ideation process while also providing a structure for future researchers to expand the use of this technology in apparel design coursework.
An araphid diatoms from marine Miocene deposits of the Fisher Massif (Prince Charles Mountains, East Antarctica)
Authors: Gogorev Rinat M. , Pushina Zinaida V.
Published: September 2024

The Late Cenozoic history of Antarctica is reflected in the few ice-free ground deposits of the continental marginal zone. While the planktonic diatom flora of the Cenozoic Antarctic, which has dominated the biocenoses of the Southern Ocean since the Eocene, has been fairly well studied based on Deep-Sea Drilling, the benthic diatoms found in sediments have been studied extremely poorly. In the materials collected during the 52nd and 53rd Russian Antarctic expeditions in 2006–2008 from deposits of the Fisher Massif (central part of the Prince Charles Mountains), a rich fossil diatom complexes were found, including more than 80 mainly benthic taxa. Of these, 13 species of araphid diatoms have been studied and described.
Comparative analysis of the diatom microtubule center components
Authors: Bedoshvili Yekaterina D. , Bayramova Elvira M. , Morozov Alexey A. , Petrova Darya P.
Published: September 2024

The diatom silica frustule formation occurs inside cells under the control of cytoskeleton and microtubule center. The composition of the diatoms microtubule center has not been previously studied. In the present study, several components of the diatom microtubule center in have been identified. Based on the genome and transcriptome data, an analysis was carried out and the structural features of the predicted amino acid sequences of GCP, protein kinase Aurora A, and centrins were revealed.
Подбор параметров обучения нейронной сети PointNext при сегментации точек лазерного отражения для государственного мониторинга земель
Authors: Дьяченко Роман Александрович , Гура Дмитрий Андреевич , Беспятчук Дарья Андреевна , Самарин Сергей Владимирович
Published: September 2024

Статья посвящена исследованию применения искусственных нейронных сетей в качестве метода обработки данных лазерного сканирования при проведении государственного мониторинга земель. Важнейшей характеристикой нейронной сети является показатель точности сегментации, поэтому целью настоящего исследования является подбор наилучших параметров обучения на примере искусственно сгенерированного облака точек лазерного отражения для повышения качества модели нейронной сети PointNext при проведении государственного мониторинга земель. В работе проанализированы результаты обучения и оценена точность полученной модели. Как результат, выявлены наилучшие параметры обучения для получения максимальной точности при обучении нейронной сети PointNext. Полученные параметры позволят уменьшить сроки проведения государственного мониторинга земель при реализации государственной программы по приватизации земельных участков из государственной собственности.
Спутниковое картирование динамики «островов тепла» г. Санкт-Петербурга
Authors: Жаркова Анна Владиславовна , Орипова Азиза Алишеровна
Published: September 2024

В данной статье приведены результаты спутникового картирования «городских островов тепла» г. Санкт-Петербурга, позволяющего оценить пространственно-временные вариации дистанционно измеренной температуры подстилающей поверхности. Актуальность работы обуславливается тем, что в настоящее время вопрос валидации показателей температуры подстилающей поверхности, рассчитанных с помощью космических снимков в динамике за несколько лет и посезонно, со значениями, полученными с помощью газоанализаторов экспериментально, подробно не изучался. Представлены результаты экспериментов по измерению концентрации монооксида углерода, температуры, влажности и давления для учета их вклада в образование «островов тепла». На основе расчетов индексных изображений, необходимых для изучения состояния вегетационной активности растений, в исследуемых территориях проведена оценка и выявлено угнетенное состояние растительности. Данные, полученные в результате экспериментов, подтверждены информацией из открытых источников. Сделан вывод о возможности дистанционного мониторинга точек перегрева подстилающей поверхности по данным ДЗЗ и Интернета вещей при увеличении выборки космических снимков, а также статистической обоснованности заключений.
Моделирование геопространства зон затопления и подтопления реки Луга
Authors: Балтыжакова Татьяна Игоревна , Шаповалова Дарья Олеговна , Выстрчил Михаил Георгиевич
Published: September 2024

В статье рассмотрен вопрос определения и установления границ зон затопления и подтопления. Так как зоны затопления и подтопления являются зонами с особыми условиями использования территорий, то их наличие накладывает значительные ограничения на ведение хозяйственной деятельности на таких территориях, что может негативно сказываться на освоении земель и экономической привлекательности местности. В рамках работы был проведен анализ нормативно-правовой документации, регламентирующей определение границ зон затопления и подтопления, а также их правовой статус. На основе анализа отечественных и зарубежный исследований были рассмотрены различные подходы к моделированию геопространств зон затопления и подтопления. Авторами были смоделированы зоны затопления и зоны подтопления для реки Луга на территории Кингисеппского района.
ANÁLISE DA ADEQUAÇÃO DO CURRÍCULO DOS CURSOS DE GRADUAÇÃO EM MEDICINA ACERCA DO SEGUIMENTO DA CARREIRA MÉDICA
Authors: Silva Itaiana Pereira Cordeiro da , Mattos Luane do Amor Divino , Rodrigues Thalyta Alves , Palheta Neto Francisco Xavier
Published: September 2024

O curso de Medicina inclui disciplinas obrigatórias e atividades extracurriculares, essenciais para a graduação. Contudo, algumas universidades não oferecem uma disciplina específica sobre a compreensão da carreira médica e suas possíveis trajetórias após a graduação. O objetivo do trabalho é avaliar a presença e a qualidade da oferta de conhecimento acerca do seguimento da carreira médica durante os anos de graduação em Medicina. Método: estudo observacional, transversal, de abordagem qualitativa, mediante Google Forms. A amostra foi composta de 81 participantes, onde a maioria graduou-se entre 2000 e 2019. Mais da metade afirma nunca ter recebido orientações ou aulas de Gestão em Saúde. A gestão do próprio negócio foi maior dificuldade enfrentada no início da carreira, sendo que quase a totalidade concordam que uma maior quantidade de aulas sobre Gestão em Saúde durante a graduação, teria contribuído positivamente para o início de sua carreira. A falta de um padrão curricular que prepare adequadamente os estudantes para o planejamento e gestão de suas carreiras merece atenção. Os resultados destacam a importância de uma abordagem mais estruturada na formação e prática profissional dos médicos, que inclua não apenas habilidades clínicas, mas também competências de gestão, finanças e empreendedorismo.
Desenvolvimento musical de crianças autistas em diferentes contextos de aprendizagem:
Authors: Do Carmo Oliveira Gleisson
Published: September 2024

Esta pesquisa, resultante de Mestrado em Música, analisou o desenvolvimento musical de duas crianças autistas, inseridas em dois distintos contextos de aprendizagem musical, com o objetivo de identificar prováveis fatores de influencia no processo. Para tanto, as crianças foram submetidas a um semestre de Educação Musical, alocadas em dois grupos: um especial, composto apenas por alunos neurodivergentes e um inclusivo, composto por alunos neurodivergentes e neurotípicos. As aulas foram filmadas e o desenvolvimento musical das crianças avaliado por um júri. Os dados obtidos passaram pela técnica Análise de Conteúdo e apontaram padrões que, por sua vez, delinearam categorias que serviram de base para a avaliação do desenvolvimento obtido pelas crianças a partir das aulas de música. Foram também realizadas entrevistas parcialmente estruturadas com os pais, para um melhor entendimento dos dados obtidos. Os resultados apontam para um significativo desenvolvimento musical/geral das crianças em seus respectivos contextos de aprendizagem, demonstrando o quão benéfico é o fazer musical, independente do contexto de aprendizagem, além de mostrar que a música, de fato, pode afetar o ser humano em sua totalidade. Foi concluído que o contexto de aprendizagem sofre inúmeras influências, que vão desde os indivíduos presentes na sala de aula, aos hábitos familiares e às características individuais do autismo. Como contribuição, a presente pesquisa esboçou o protocolo que deu origem à Escala XXX, atualmente validada.
Impactos da musicoterapia em grupo na prontidão para mudança de adultos com transtornos por uso de substâncias
Authors: Jácome Nascimento Leonardo , Gonçalves Pedrosa Frederico
Published: September 2024

Este estudo investigou os impactos da musicoterapia em grupo na prontidão para mudança de homens com Transtornos por Uso de Substâncias. Para tanto utilizamos de metodologia quantitativa em uma investigação controlada, na qual o grupo controle participou de atividades de escuta musical e demonstrou maior prontidão para mudança em comparação ao grupo de intervenção, que recebeu musicoterapia estruturada. Por outro lado, o grupo de intervenção exibiu correlações significativas entre os efeitos percebidos da musicoterapia e os estágios de contemplação e prontidão para mudança, sugerindo que a musicoterapia influenciou positivamente essas variáveis, especialmente no estágio de contemplação. Os resultados também indicaram que o impacto da musicoterapia se tornou mais significativo à medida que as sessões se desenvolviam, sendo mais evidente após aproximadamente um mês de intervenção. Esses achados sugerem o potencial da musicoterapia em grupo como uma abordagem eficaz para promover a prontidão para mudança em pacientes com TUS. No entanto, é importante ressaltar que o tamanho amostral foi limitado, o que pode ter influenciado os resultados. Portanto, estudos futuros com amostras maiores podem fornecer insights adicionais sobre a eficácia da musicoterapia no tratamento de TUS e sua relação com a prontidão para mudança.
Dying for a canape: the welfare implications associated with both traditional and “ethical” production of caviar from sturgeon
Authors: Lambert Helen , Emam Wasseem
Published: September 2024

The farming of sturgeon to produce caviar is increasing globally, even though little is known about the welfare implications of aquaculture for these unique, long-living, and large animals. The use of non-lethal methods for egg harvesting is increasing, as these methods are thought to offer a more ethical alternative to traditional methods where the female is killed. However, these “non-lethal” methods raise significant welfare concerns including routine handling, surgical procedures, and painful procedures, and could potentially perpetuate suffering. Consequently, there is an urgent need for significant exploration and research into this field. This review presents and discusses some of the welfare concerns associated with producing caviar from sturgeon, including the traditional and non-lethal methods of egg harvesting and the concerns associated with rearing them in aquaculture systems. It concludes in stating that the welfare issues involved with non-lethal caviar production are too sizeable to warrant its description as an “ethical or humane” alternative to traditional caviar production.
Two roads diverged in a cell: insights from differential exosome regulation in polarized cells
Authors: Komori Tadayuki , Fukuda Mitsunori
Published: September 2024

Exosomes are extracellular vesicles involved in intercellular signaling, carrying various cargo from microRNAs to metabolites and proteins. They are released by practically all cells and are highly heterogenous due to their origin and content. Several groups of exosomes are known to be involved in various pathological conditions including autoimmune, neurodegenerative, and infectious diseases as well as cancer, and therefore a substantial understanding of their biogenesis and release is crucial. Polarized cells display an array of specific functions originated from differentiated membrane trafficking systems and could lead to hints in untangling the complex process of exosomes. Indeed, recent advances have successfully revealed specific regulation pathways for releasing different subsets of exosomes from different sides of polarized epithelial cells, underscoring the importance of polarized cells in the field. Here we review current evidence on exosome biogenesis and release, especially in polarized cells, highlight the challenges that need to be combatted, and discuss potential applications related to exosomes of polarized-cell origin.
Mixed methods research teams: leveraging integrative teamwork for addressing complex problems
Authors: Poth Cheryl , Georgiou George , Mack Emily , Kierstead Matthew
Published: September 2024

Mixed methods research teams have garnered increased attention for their leveraging of diverse disciplinary and methodological expertise in pursuit of complex problems. We advance our theoretical viewpoint of integrative mixed methods research teamwork as necessary with empirical evidence demonstrating the equipping mixed methods researchers to study complex problems involving interacting systems and lacking known solutions. Integrative mixed methods research teamwork is distinguishable by the purposeful integration of qualitative and quantitative perspectives to generate novel outcomes that are greater than the sum of individual members’ contributions. Among the key dilemmas faced by mixed methods researchers wanting to work integratively within a team is the lack of practical guidance for how to get started, how to recognize the emergence of synergistic outcomes, and how to sustain a team’s integrative work. To begin addressing this gap, we describe three practical insights gleaned from examining our team interactions and outcomes using a reflection-in-action process during a recent empirical mixed methods case study of literacy practices. In our examination, we test the practical usefulness of a theoretical framework for demystifying the development of a mixed methods research team’s integrative capacity. Our insights contribute to refining teamwork practices by identifying enablers of integrative capacity and proposing ways to overcome hindrances that have not been previously elucidated. We argue that the capacity for integrative teamwork is essential for researchers employing mixed methods, allowing them to leverage inherent synergies when addressing complex problems.
A nomogram model for early recurrence of HBV-related hepatocellular carcinomas after radical hepatectomy
Authors: Zhu Yu , Wang Ai-Dong , Gu Ling-Ling , Dai Qi-Qiang , Zheng Guo-Qun , Chen Ting , Wu Chun-Long , Jia Wei-Dong , Zhang Fa-Biao
Published: September 2024

Background

To identify the risk factors and construct a predictive model for early recurrence of hepatitis B virus(HBV-)- related hepatocellular carcinomas(HCCs) after radical resection.

Data and methods

A total of 465 HBV-related HCC patients underwent radical resections between January 1, 2012 and August 31, 2018.Their data were collected through the inpatient information management system of the First Affiliated Hospital of University of Science and Technology of China. Survival and subgroup analyses of early recurrence among male and female patients were performed using Kaplan-Meier curves. The independent risk factors associated with early postoperative tumor recurrence were analyzed using multivariate Cox proportional hazards regression model. Based on these independent risk factors, a risk function model for early recurrence was fitted, and a column chart for the prediction model was drawn for internal and external validation.

Results

A total of 181 patients developed early recurrences, including 156 males and 25 females. There was no difference in the early recurrence rates between males and females. Tumor diameters>5cm, microvascular invasion and albumin level<35 g/L were independent risk factors for early recurrence. A nomogram for the early recurrence prediction model was drawn; the areas under the curve for the model and for external verification were 0.638 and 0.655, respectively.

Conclusion

Tumor diameter>5 cm, microvascular invasion, and albumin level<35 g/L were independent risk factors for early recurrence. The prediction model based on three clinical indicators could predict early recurrence, with good discrimination, calibration, and extrapolation.
A PRDM16-driven signal regulates body composition in testosterone-treated hypogonadal men
Authors: Bathina Siresha , Colleluori Georgia , Villareal Dennis T. , Aguirre Lina , Chen Rui , Armamento-Villareal Reina
Published: September 2024

Background

Testosterone (T) therapy increases lean mass and reduces total body and truncal fat mass in hypogonadal men. However, the underlying molecular mechanisms for the reciprocal changes in fat and lean mass in humans are not entirely clear.

Methods

Secondary analysis of specimens obtained from a single-arm, open-label clinical trial on pharmacogenetics of response to T therapy in men with late-onset hypogonadism, conducted between 2011 and 2016 involving 105 men (40-74 years old), who were given intramuscular T cypionate 200 mg every 2 weeks for 18 months. Subcutaneous fat (SCF), peripheral blood mononuclear cells (PBMC) and serum were obtained from the participants at different time points of the study. We measured transcription factors for adipogenesis and myogenesis in the SCF, and PBMC, respectively, by real-time quantitative PCR at baseline and 6 months. Serum levels of FOLLISTATIN, PAX7, MYOSTATIN, ADIPSIN, and PRDM16 were measured by ELISA.

Results

As expected, there was a significant increase in T and estradiol levels after 6 months of T therapy. There was also a reduction in fat mass and an increase in lean mass after 6 months of T therapy. Gene-protein studies showed a significant reduction in the expression of the adipogenic markers PPARγ in SCF and ADIPSIN levels in the serum, together with a concomitant significant increase in the expression of myogenic markers, MYOD in PBMC and PAX7 and FOLLISTATIN levels in the serum after 6 months of T therapy compared to baseline. Interestingly, there was a significant increase in the adipo-myogenic switch, PRDM16, expression in SCF and PBMC, and in circulating protein levels in the serum after 6 months of T therapy, which is likely from increased estradiol.

Conclusion

Our study supports that molecular shift from the adipogenic to the myogenic pathway in men with hypogonadism treated with T could be mediated directly or indirectly by enhanced PRDM16 activity, in turn a result from increased estradiol level. This might have led to the reduction in body fat and increase in lean mass commonly seen in hypogonadal men treated with T.
Analysis of risk factors for papillary thyroid carcinoma and the association with thyroid function indicators
Authors: Liu Jianning , Feng Zhuoying , Gao Ru , Liu Peng , Meng Fangang , Fan Lijun , Liu Lixiang , Du Yang
Published: September 2024

Objective

This study aims to analyze the relationship between papillary thyroid carcinoma (PTC) and various factors.

Methods

The study involved two groups—PTC patients and non-PTC controls. We utilized binary logistic regression and Least Absolute Shrinkage and Selection Operator (Lasso) regression for variable selection and risk factor analysis. Correlation analysis was performed using Spearman’s rank correlation. The diagnostic value of thyroid stimulating hormone (TSH) levels for PTC was assessed using Receiver Operating Characteristic (ROC) curves.

Results

PTC patients exhibited higher body mass index (BMI) (23.71 vs. 22.66, p<0.05) and TSH levels (3.38 vs. 1.59, p<0.05). Urinary iodine concentration (UIC) was an independent predictor of PTC (OR=1.005, p<0.05). The optimal TSH threshold for PTC diagnosis was 2.4 mIU/L [The Area Under the Curve (AUC)=67.3%, specificity=71.4%, sensitivity=70.1%]. TSH levels positively correlated with BMI (r=0.593, p<0.05) and UIC (r=0.737, p<0.05).

Conclusions

UIC may be an independent predictor of PTC, and TSH levels have some diagnostic value for identifying PTC.