bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Antibodies to Ustekinumab Is Associated with Loss of Response in Patients with Inflammatory Bowel Disease
Authors: Roblin Xavier , Duru Gérard , Papamichael Konstantinos , Cheifetz Adam S. , Kwiatek Sandy , Berger Anne-Emmanuelle , Barrau Mathilde , Waeckel Louis , Nancey Stephane , Paul Stephane
Published: May 2023

Monitoring of anti-drug antibodies in patients on ustekinumab is not routinely recommended in patients with inflammatory bowel disease (IBD) due to low rates of immunogenicity. Aim of study: The purpose of this study was to investigate the relationship between anti-drug antibodies detected by a drug-tolerant assay and loss of response (LOR) to therapy in a cohort of patients with IBD being treated with ustekinumab. Patients and Methods: This retrospective study consecutively enrolled all adult patients with moderate to severe active IBD who had at least 2 years of follow-up after ustekinumab was initiated. LOR was defined as CDAI > 220 or HBI > 4 for Crohn’s disease (CD) and partial Mayo subscore > 3 for ulcerative colitis (UC) and with a modification in disease management. Results: Ninety patients were included (78 CD and 12 UC; mean age 37 years). Median levels of anti-ustekinumab antibodies (ATU) were significantly higher in patients with LOR compared to those with ongoing clinical response (15.2 µg/mL-eq CI (7.9–21.5) and 4.7 µg/mL-eq CI (2.1–10.5), respectively; p = 0.04). The area under the ROC curve (AUROC) for ATU in predicting LOR was 0.76. The optimal cut-off point for identifying patients with LOR was 9.5 µg/mL-eq with a sensitivity of 80% and specificity of 85%. Uni- and multivariate analyses showed that serum ATU ≥ 9.5 µg/mL-eq (hazard ratio (HR) 2.54, 95%CI (1.80–5.93)), p = 0.022, prior vedolizumab (HR 2.78, 95%CI (1.09–3.34), p = 0.019) and prior azathioprine (HR 0.54, 95%CI (0.20–0.76), p = 0.014) exposures were the only factors independently associated with LOR to UST. Conclusion: In our real-life cohort, ATU was identified as an independent predictor of LOR to ustekinumab in patients with IBD.
Surgical Treatment of Juvenile Idiopathic Arthritis in the Era of Novel Drug Therapies
Authors: Klein Céline , Barbier Vincent , Glorion Christophe , Gouron Richard
Published: May 2023

Juvenile idiopathic arthritis is the most common chronic rheumatic disease encountered in children under the age of sixteen and causes significant impairments in daily life. Over the last two decades, the introduction of new drug treatments (including disease-modifying antirheumatic drugs and biologics) has changed the course of this disease, thus reducing the indication for surgery. However, some patients fail to respond to drug therapy and thus require personalized surgical management, e.g., the local reduction of joint effusion or a synovial pannus (via intra-articular corticosteroid injections, synovectomy, or soft tissue release), and management of the sequelae of arthritis (such as growth disorders and joint degeneration). Here, we provide an overview of the surgical indications and outcomes of the following interventions: intra-articular corticosteroid injections, synovectomy, soft tissue release, surgery for growth disorders, and arthroplasty.
Consensus Statements from the Diabetologists & Endocrinologists Alliance for the Management of People with Hypertension and Type 2 Diabetes Mellitus
Authors: Tong Peter Chun-Yip , Chan Susanna Chi-Pun , Chan Wing-Bun , Ho Kelvin Kai-Leung , Leung Godwin Tat-Chi , Lo Stanley Hok-King , Mak Gary Yiu-Kwong , Tse Tak-Sun
Published: May 2023

Hypertension and type 2 diabetes mellitus (T2DM) are important, intertwined public health issues. People with both conditions face significantly elevated risks of cardiovascular (CV) and renal complications. To optimize patient care, a multidisciplinary expert panel met to review recent evidence on optimal blood pressure (BP) targets, implications of albuminuria, and treatment regimens for hypertensive patients with T2DM, with the aim of providing recommendations for physicians in Hong Kong. The panel reviewed the relevant literature, obtained by searching PubMed for the publication period from January 2015 to June 2021, to address five discussion areas: (i) BP targets based on CV/renal benefits; (ii) management of isolated systolic or diastolic hypertension; (iii) roles of angiotensin II receptor blockers; (iv) implications of albuminuria for CV/renal events and treatment choices; and (v) roles and tools of screening for microalbuminuria. The panel held three virtual meetings using a modified Delphi method to address the discussion areas. After each meeting, consensus statements were derived and anonymously voted on by every panelist. A total of 17 consensus statements were formulated based on recent evidence and expert insights regarding cardioprotection and renoprotection for hypertensive patients with T2DM.
In Vivo and In Vitro Investigation of a Novel Gelatin/Sodium Polyacrylate Composite Hemostatic Sponge for Topical Bleeding
Authors: Jahan Nusrat , Ibne Mahbub Md Sowaib , Lee Byong-Taek , Bae Sang Ho
Published: May 2023

Designing a functional and efficient blood-clotting agent is a major challenge. In this research, hemostatic scaffolds (GSp) were prepared from the superabsorbent, inter-crosslinked polymer sodium polyacrylate (Sp) bound to a natural protein gelatin (G) loaded with thrombin (Th) by a cost-effective freeze-drying method. Five compositions were grafted (GSp0.0, Gsp0.1, GSp0.2, GSp0.3, GSp0.3-Th) where the concentration of Sp varied but the ratios of G remained the same. The fundamental physical characteristics that increased the amounts of Sp with G gave synergistic effects after interacting with thrombin. Due to the presence of superabsorbent polymer (SAP) swelling capacities in GSp0.3 and GSp0.3-Th surge forward 6265% and 6948%, respectively. Pore sizes became uniform and larger (ranging ≤ 300 μm) and well-interconnected. The water-contact angle declined in GSp0.3 and GSp0.3-Th to 75.73 ± 1.097 and 75.33 ± 0.8342 degrees, respectively, thus increasing hydrophilicity. The pH difference was found to be insignificant as well. In addition, an evaluation of the scaffold in in vitro biocompatibility with the L929 cell line showed cell viability >80%, so the samples were nontoxic and produced a favorable environment for cell proliferation. The composite GSp0.3-Th revealed the lowest HR (%) (2.601%), and the in vivo blood-clotting time (s) and blood loss (gm) supported hemostasis. Overall, the results showed that a novel GSp0.3-Th scaffold can be a potential candidate as a hemostatic agent.
Wood as Possible Renewable Material for Bone Implants—Literature Review
Authors: Nefjodovs Vadims , Andze Laura , Andzs Martins , Filipova Inese , Tupciauskas Ramunas , Vecbiskena Linda , Kapickis Martins
Published: May 2023

Bone fractures and bone defects affect millions of people every year. Metal implants for bone fracture fixation and autologous bone for defect reconstruction are used extensively in treatment of these pathologies. Simultaneously, alternative, sustainable, and biocompatible materials are being researched to improve existing practice. Wood as a biomaterial for bone repair has not been considered until the last 50 years. Even nowadays there is not much research on solid wood as a biomaterial in bone implants. A few species of wood have been investigated. Different techniques of wood preparation have been proposed. Simple pre-treatments such as boiling in water or preheating of ash, birch and juniper woods have been used initially. Later researchers have tried using carbonized wood and wood derived cellulose scaffold. Manufacturing implants from carbonized wood and cellulose requires more extensive wood processing—heat above 800 °C and chemicals to extract cellulose. Carbonized wood and cellulose scaffolds can be combined with other materials, such as silicon carbide, hydroxyapatite, and bioactive glass to improve biocompatibility and mechanical durability. Throughout the publications wood implants have provided good biocompatibility and osteoconductivity thanks to wood’s porous structure.
Evaluation of Additively-Manufactured Internal Geometrical Features Using X-ray-Computed Tomography
Authors: Baumgärtner Benjamin , Rothfelder Richard , Greiner Sandra , Breuning Christoph , Renner Jakob , Schmidt Michael , Drummer Dietmar , Körner Carolin , Markl Matthias , Hausotte Tino
Published: May 2023

X-ray-computed tomography (CT) is today’s gold standard for the non-destructive evaluation of internal component defects such as cracks and porosity. Using automated standardized evaluation algorithms, an analysis can be performed without knowledge of the shape, location, or size of the defects. Both the measurement and the evaluation are based on the fact that the component has no internal structures or cavities. However, additive manufacturing (AM) and hybrid subtractive procedures offer the possibility of integrating internal structures directly during the building process. The examination of powder bed fusion (PBF) samples made of Ti64 and PA12 showed that the standardized evaluation methods were not able to identify internal structures correctly. Different evaluation methods for the CT-measured values were analyzed and recommendations on a procedure for measuring internal structures are given.
Sedimentological Controls on the Reservoir Characteristics of the Mid-Triassic Tredian Formation in the Salt and Trans-Indus Surghar Ranges, Pakistan: Integration of Outcrop, Petrographic, and SEM Analyses
Authors: Qureshi Kamil A. , Arif Mohamad , Basit Abdul , Ahmad Sajjad , Janjuhah Hammad Tariq , Kontakiotis George
Published: May 2023

The current study uses an integrated lithofacies, optical microscopy, and scanning electron microscopy (SEM) analysis to investigate the sedimentary processes, depositional architecture, and reservoir rock potential of the Tredian Formation’s (Mid-Triassic) mixed siliciclastic and carbonate succession in the Salt and Trans-Indus Ranges. The formation has been divided litho-stratigraphically into two components: the lower Landa Member, which consists of fine-grained sandstone and shale, and the upper Khatkiara Member, which consists of coarse-grained sandstone. Based on sedimentary structures and lithology, four distinct types of lithofacies are identified. Two lithofacies representing sandstones interbedded with shale (LF1) and thick-bedded sandstone (LF2) lithofacies suggestive of fluvio-deltaic settings are among them. Another two lithofacies of thin-bedded sandstone (LF3) and dolomite (LF4) suggest a tidal flat depositional environment, correspondingly. The petrographic examination of the Tredian sandstones indicates a lithology ranging from sub-feldspathic arenite to feldspathic arenite with moderate packing. The presence of primary calcite cement, silica cement, and iron oxide/hydroxide cements were shown by the diagenetic investigation, which was supported by SEM studies. In addition, secondary cements include ferroan-dolomite, chlorite, and illite, which is linked with chemical alteration of unstable grains. The paragenetic sequence depicts the diagenetic evolution of the Tredian sandstone from early to late diagenetic phases. The reservoir quality of the LF1 and LF4 lithofacies has been destroyed by early-stage calcite cementation, but the lithofacies LF2 and LF3 have a strong reservoir potential owing to the scarcity of calcite cement, dissolution of unstable feldspar grains, and grain fracture.
Intervehicle Security-Based Robust Neural Formation Control for Multiple USVs via APS Guidance
Authors: Zhang Guoqing , Yin Shilin , Huang Chenfeng , Zhang Weidong
Published: May 2023

This paper focuses on the intervehicle security-based robust formation control of unmanned surface vehicles (USVs) to implement the formation switch mission. In the scheme, a novel adaptive potential ship (APS)-based guidance principle is developed to prevent intervehicle collisions, which is common and threatening when maneuvering a formation switch. By employing the artificial potential field (APF), the APS can program the real-time attitude reference for USVs by using the security intervehicle distance while achieving the path-following task. As for the control part, a robust adaptive formation control algorithm is proposed to effectively stabilize the USVs to the APS via the fusion of the disturbance observer (DOB) and by using the robust neural damping technique. Regarding the merits of the improved design of the DOB, the weight compression of the neural networks can effectively simplify the structure of the DOB and enhance the observation accuracy of the external disturbance. This can facilitate the avoidance of intervehicle collisions and guarantee the application of the theoretical algorithm in engineering practice. Considerable effort has been made to obtain the semiglobally uniform ultimate bounded (SGUUB) stability via theoretical analysis. Finally, with the sailing scene in a narrow channel, the simulated experiment is illustrated to verify the security performance of the proposed strategy.
Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?
Authors: Brandalise Federico , Roda Elisa , Ratto Daniela , Goppa Lorenzo , Gargano Maria Letizia , Cirlincione Fortunato , Priori Erica Cecilia , Venuti Maria Teresa , Pastorelli Emanuela , Savino Elena , Rossi Paola
Published: May 2023

A growing number of studies is focusing on the pharmacology and feasibility of bioactive compounds as a novel valuable approach to target a variety of human diseases related to neurological degeneration. Among the group of the so-called medicinal mushrooms (MMs), Hericium erinaceus has become one of the most promising candidates. In fact, some of the bioactive compounds extracted from H. erinaceus have been shown to recover, or at least ameliorate, a wide range of pathological brain conditions such as Alzheimer’s disease, depression, Parkinson’s disease, and spinal cord injury. In a large body of in vitro and in vivo preclinical studies on the central nervous system (CNS), the effects of erinacines have been correlated with a significant increase in the production of neurotrophic factors. Despite the promising outcome of preclinical investigations, only a limited number of clinical trials have been carried out so far in different neurological conditions. In this survey, we summarized the current state of knowledge on H. erinaceus dietary supplementation and its therapeutic potential in clinical settings. The bulk collected evidence underlies the urgent need to carry out further/wider clinical trials to prove the safety and efficacy of H. erinaceus supplementation, offering significant neuroprotective applications in brain pathologies.
Special Issue: Fungal Nanotechnology 2
Authors: Abd-Elsalam Kamel A.
Published: May 2023

Fungal nanotechnology provides techniques useful for molecular and cell biology, medicine, biotechnology, agriculture, veterinary physiology, and reproduction. This technology also has exciting potential applications in pathogen identification and treatment, as well as impressive outcomes in the animal and food systems. Myconanotechnology is a viable option for the synthesis of green nanoparticles because it is simple, affordable, and more environmentally friendly to use fungal resources. Mycosynthesis nanoparticles can be used for various purposes, such as pathogen detection and diagnosis, control, wound healing, drug delivery, cosmetics, food preservation, and textile fabrics, among other applications. They can be applied to a variety of industries, such as agriculture, manufacturing, and medicine. Gaining deeper comprehension of the molecular biology and genetic components underlying the fungal nanobiosynthetic processes is becoming increasingly important. This Special Issue aims to showcase recent advancements in invasive fungal diseases caused by human, animal, plant, and entomopathogenic fungi that are being identified, treated, and treated using antifungal nanotherapy. Utilizing fungus in nanotechnology has several benefits, such as their capacity to create nanoparticles with distinctive characteristics. As an illustration, some fungi can create nanoparticles that are highly stable, biocompatible, and have antibacterial capabilities. Fungal nanoparticles may be used in a variety of industries, including biomedicine, environmental cleanup, and food preservation. Fungal nanotechnology is also a sustainable and environmentally beneficial method. Fungi are an appealing alternative to conventional chemical methods of creating nanoparticles because they are simple to cultivate using affordable substrates and may be cultivated under diverse conditions.
Association between Periodontitis Extent, Severity, and Progression Rate with Systemic Diseases and Smoking: A Retrospective Study
Authors: Chatzopoulos Georgios S. , Jiang Ziou , Marka Nicholas , Wolff Larry F.
Published: May 2023

Background: The aim of this study was to analyze the relationship between extent, severity (stage), and rate of progression (grade) of periodontitis with systemic diseases as well as smoking using a large database. Methods: Patients’ records identified in the BigMouth Dental Data Repository with a periodontal diagnosis based on the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions were evaluated. Patients were further categorized based on extent, severity, and rate of progression. Data were extracted from patients’ electronic health records including demographic characteristics, dental procedural codes, and self-reported medical conditions, as well as the number of missing teeth. Results: A total of 2069 complete records were ultimately included in the analysis. Males were more likely to have generalized periodontitis and stage III or IV periodontitis. Older individuals were more likely diagnosed with grade B and stage III or IV periodontitis. Individuals with generalized disease, grade C, and stage IV demonstrated a significantly higher number of missing teeth. Higher numbers of tooth loss reported during supportive periodontal treatment were noted in generalized disease and stage IV periodontitis. Multiple sclerosis and smoking were significantly associated with grade C periodontitis. Conclusions: Within the limitations of this retrospective study that utilized the BigMouth dental data repository, smokers were significantly associated with rapid progression of periodontitis (grade C). Gender, age, number of missing teeth, and number of tooth loss during supportive periodontal treatment were associated with disease characteristics.
Live Commerce Platforms: A New Paradigm for E-Commerce Platform Economy
Authors: Kim Junic , He Nianwen , Miles Ian
Published: May 2023

Live commerce is creating a new paradigm for e-commerce platform economy. This study aims to provide effective strategies that can be used for live commerce platform operation and management by analysing factors that influence consumer intentions to purchase. As a combination of e-commerce and live streaming, live commerce allows businesses to demonstrate products, answer customer questions, and provide personalized recommendations in a way that replicates the in-store experience. Thus, this study aims to provide effective strategies that can be used for the new e-commerce platform economy and market competition that live commerce platforms build by analysing factors that influence consumer intentions to purchase. This study was conducted using structural equation modeling (SEM) based on a survey of 237 live commerce users. The results of this study lend platform-providers a more comprehensive understanding of the functional and social factors that influence consumers’ decisions to make purchases on such platforms. The outcomes can further serve as a basis for improving platforms, providing consumers with a better consumption experience, and offering theoretical support for consumers to use related services rationally and efficiently.
Urban Grassland Afforestation as a Public Land Management Tool for Environmental Improvement: The Example of Krakow (Poland)
Authors: Podwika Miłosz , Ciarkowska Krystyna , Solek-Podwika Katarzyna
Published: May 2023

Afforestation can play a significant role in greenhouse gas emission reduction through increased carbon (C) sequestration in the biomass and soil. However, its environmental effects, especially through changes in soil characteristics as a result of afforestation, are still poorly understood. In this work, we studied the response of grassland soils derived from two different parent materials to afforestation. We measured the basic soil properties, including pH, C accumulation, nutrient contents and enzyme activity, in soils from grasslands and mature forests. We focused on the parameters associated with organic matter and the changes resulting from afforestation. We established that in the humus layers, habitat played a more important role in creating the soil properties, including organic-C accumulation, than land use (forest vs. grassland). We created models to explain the C storage in the soils, which indicated the substantial role of certain conditions in promoting the stabilisation of the organic matter, such as pH, and the amount of clay, humines and residue. We determined negative changes in the soil properties when compared with grassland and forest soils, but we found increased C storage, which counteracts the increased emission of carbon dioxide into the atmosphere. The results of our work may be of use for afforestation planners and urban managers.
Land Cover Change and Food Security in Central Sumba: Challenges and Opportunities in the Decentralization Era in Indonesia
Authors: Ngongo Yohanis , deRosari Bernard , Basuki Tony , Njurumana Gerson Ndawa , Nugraha Yudistira , Harianja Alfonsus Hasudungan , Ardha Mohammad , Kustiyo Kustiyo , Shofiyati Rizatus , Heryanto Raden Bambang , Rawung Jefny Bernedi Markus , Sondakh Joula Olvy Maya , Senewe Rein Estefanus , daSilva Helena , Hutapea Ronald Timbul Pardamean , Mattitaputty Procula Rudlof , Kenduballa Yosua Pieter , Kotta Noldy Rusminta Estorina , Seran Yohanes Leki , Hau Debora Kana , Oktaviani Dian , Nugroho Hunggul Yudono Setio Hadi
Published: May 2023

This study focuses on land cover and land management changes in relation to food security and environmental services in a semi-arid area of East Nusa Tenggara (ENT), Indonesia. The study was conducted in the Central Sumba District of ENT province. A classification and regression tree (CART) for land cover classification was analyzed using machine learning techniques through the implementation of the Google Earth Engine. A Focus Group Discussion (FGD) survey followed by in-depth interviews was conducted for primary data collection, involving a total of 871 respondents. The socio-economic data were statistically analyzed descriptively using non-parametric tests. The study showed that (1) there has been a substantial change in land use during the devolution era that has both positive and negative implications for food security and environmental services; (2) there has been population pressure in fertile and agricultural land as a direct impact of the development of city infrastructure; and (3) national intervention through the Food Estate program has fostered and shaped land use change and land management in the Central Sumba District. The study highlights the importance of the devolution spirit in aiding the management of limited arable/agricultural land in predominantly semi-arid areas to ensure food security and environmental services.
Cardiometabolic Patient-Related Factors Influencing the Adherence to Lifestyle Changes and Overall Treatment: A Review of the Recent Literature
Authors: Kalantzi Vasiliki , Kalafati Ioanna , Belitsi Vasiliki , Tsiampalis Thomas , Koutsonasios Ioannis , Androutsos Odysseas , Bonoti Fotini , Panagiotakos Demosthenes , Kosti Rena
Published: May 2023

It is well acknowledged that most of the modifiable risk factors for Cardiovascular Diseases (CVDs) can be averted through lifestyle modifications beyond medication adherence. This review aims to critically evaluate the cardiometabolic (CM) patient-related factors that influence the adherence to lifestyle changes studied alone and/or in combination with medication. A comprehensive literature search of PubMed articles from 2000 to 2023 retrieved 379 articles. After removing the articles which were not relevant, a total of 28 cross-sectional studies was chosen (12 qualitative, and 16 quantitative). The findings confirmed that five groups of factors influence patients’ adherence to overall treatment: (1) health beliefs, knowledge, and perceptions regarding the risks and challenges of disease and medication intake along with adherence process perceptions; (2) self-concept; (3) emotions; (4) patient–healthcare providers relationship/communication and (5) social and cultural interactions. It is worth mentioning that cultural issues, such as culinary particularities, ethnic identity, social life as well as patients’ skills and abilities, play a profound role in the effectiveness of the recommended lifestyle modifications beyond the aforementioned common factors. The need for clear-cut culturally adapted guidelines along with personalized advice from physicians is imperative as it could improve patients’ self-efficacy. These socio-psychological factors should be seriously considered as a means to increase the effectiveness of future community prevention programs.
Electroacupuncture Attenuates Fibromyalgia Pain via Toll-like Receptor 4 in the Mouse Brain
Authors: Lai Po-Chih , Yen Chia-Ming , Lin Ming-Chia , Chen Yung-Hsiang , Liao Hsien-Yin , Huang Yu-Wei , Lin Yi-Wen
Published: May 2023

Background: Fibromyalgia (FM) is characterized by complex pain symptoms lacking impersonal considerations in diagnosis and treatment evaluation, which often happens in women. Chronic and persistent widespread pain is the key symptom disturbing patients with FM, leading to depression, obesity, and sleep disturbances. Toll-like receptor 4 (TLR4) activation produces a harmful sensory input involved in central pain; this is the focus of this study. Electroacupuncture (EA) has beneficial effects in reducing FM pain, but its connection with TLR4 signaling is still unknown. Methods: Intermittent cold stress significantly induced mechanical and thermal pain. EA, but not sham EA, reliably attenuated mechanical and thermal hyperalgesia. The increased inflammatory mediators in FM mice were reduced in the EA group, but not in the sham group. Results: All TLR4 and related molecule levels increased in the FM mice’s hypothalamus, periaqueductal gray (PAG), and cerebellum. These increases could be attenuated by EA but not sham stimulation. Activation of TLR4 by lipopolysaccharide (LPS) significantly induced FM and can be further reversed by a TLR4 antagonist. Conclusions: These mechanisms provide evidence that the analgesic effect of EA is related to the TLR4 pathway. In addition, we showed that inflammation can activate the TLR4 pathway and provided new possible therapeutic targets for FM pain.
Comparison of (K0.5Na0.5)NbO3 Single Crystals Grown by Seed-Free and Seeded Solid-State Single Crystal Growth
Authors: Fisher John G. , Sim Su-Hyeon , Ðoàn Trung Thành , Uwiragiye Eugenie , Mok Jungwi , Lee Junseong
Published: May 2023

(K0.5Na0.5)NbO3-based piezoelectric ceramics are of interest as a lead-free replacement for Pb(Zr,Ti)O3. In recent years, single crystals of (K0.5Na0.5)NbO3 with improved properties have been grown by the seed-free solid-state crystal growth method, in which the base composition is doped with a specific amount of donor dopant, inducing a few grains to grow abnormally large and form single crystals. Our laboratory experienced difficulty obtaining repeatable single crystal growth using this method. To try and overcome this problem, single crystals of 0.985(K0.5Na0.5)NbO3-0.015Ba1.05Nb0.77O3 and 0.985(K0.5Na0.5)NbO3-0.015Ba(Cu0.13Nb0.66)O3 were grown both by seed-free solid-state crystal growth and by seeded solid-state crystal growth using [001] and [110]-oriented KTaO3 seed crystals. X-ray diffraction was carried out on the bulk samples to confirm that single-crystal growth had taken place. Scanning electron microscopy was used to study sample microstructure. Chemical analysis was carried out using electron-probe microanalysis. The single crystal growth behaviour is explained using the mixed control mechanism of grain growth. Single crystals of (K0.5Na0.5)NbO3 could be grown by both seed-free and seeded solid-state crystal growth. Use of Ba(Cu0.13Nb0.66)O3 allowed a significant reduction in porosity in the single crystals. For both compositions, single crystal growth on [001]-oriented KTaO3 seed crystals was more extensive than previously reported in the literature. Large (~8 mm) and relatively dense (<8% porosity) single crystals of 0.985(K0.5Na0.5)NbO3-0.015Ba(Cu0.13Nb0.66)O3 can be grown using a [001]-oriented KTaO3 seed crystal. However, the problem of repeatable single crystal growth remains.
Effect of Post-Welding Aging Treatment on the Microstructure and High-Temperature Properties of Inertia Friction Welded GH4065A Joint
Authors: Cao Sheng , Li Xiaoguang , Liu Jiatao , Zhang Chunbo , Zhou Jun , Cui Lei
Published: May 2023

In this study, post-welding aging treatments were applied to a novel Ni-based superalloy GH4065A inertia friction welding (IFW) joint to improve its high-temperature properties. The effect of aging treatment on the microstructure and creep resistance of the IFW joint was systematically investigated. The results indicated that the original γ′ precipitates in the weld zone almost completely dissolved during the welding process, and fine tertiary γ′ precipitated during the subsequent cooling process. Aging treatment did not significantly change the characteristics of grain structures and primary γ′ in the IFW joint. After aging, the size of tertiary γ′ in the weld zone and secondary γ′ in the base material increased, but their morphology and volume fraction did not change evidently. After 760 °C, 5 h aging treatment, the tertiary γ′ in the weld zone of the joint grew from 12.4 nm to 17.6 nm. Correspondingly, the creep rupture time of the joint at 650 °C and 950 MPa increased from 7.51 h to 147.28 h, which is about 19.61 times higher than that of the as-welded joint. The creep rupture was more likely to occur in the base material instead of the weld zone for the IFW joint. This revealed that the creep resistance of the weld zone was significantly improved after aging due to the growth of tertiary γ′. However, increasing the aging temperature or extending the aging time promoted the growth of secondary γ′ in the base material, and meanwhile, M23C6 carbides tended to continuously precipitate at the grain boundaries of the base material. It might decrease the creep resistance of the base material.
Residual Chlorella-Based Cellulose Nanofibers and Their Quaternization Modification and Efficient Anionic Dye Adsorption
Authors: Zhang Lina , Huo Xiaomin , Zhu Jin , Liu Changbin , Wang Lianfeng
Published: May 2023

Dye is an anionic common pollutant in industrial wastewater and poses a great threat to the environment and human health. Owing to its advantageous adsorption capacity, nanocellulose is widely used for wastewater treatment. The cell walls of Chlorella mainly comprise cellulose instead of lignin. In this study, residual Chlorella-based cellulose nanofiber (CNF) and cationic cellulose nanofiber (CCNF) with surface quaternization were prepared through homogenization. Moreover, Congo red (CR) was used as a model dye to measure the adsorption capacity of CNF and CCNF. The adsorption capacity was almost saturated when CNF and CCNF contacted CR for 100 min, and the adsorption kinetics coincided with the pseudo-secondary kinetics model. The initial concentration of CR considerably affected its adsorption on CNF and CCNF. Below the initial concentration of 40 mg/g, the adsorption on CNF and CCNF considerably increased with the increase in the initial concentration of CR. Based on the sorption isotherms analysis of CNF and CCNF, the Langmuir model fitted best with the experimental data. Thus, CNF and CCNF surfaces were uniform, and monolayer adsorption occurred. The adsorption of CR on CNF and CCNF was greatly affected by the pH value, and the acidic medium favored the adsorption of CR (especially for CCNF). CCNF showed a more advantageous adsorption capacity, with a maximum value of 1657.89 mg/g, compared to that of CNF (190.0 mg/g). According to the findings of this study, residual Chlorella-based CCNF could be a very promising adsorbent candidate for removing anionic dyes from wastewater.
Terahertz Spectroscopy Characterization and Prediction of the Aging Degree of Polyethylene Pipes Based on PLS
Authors: Ren Jiaojiao , Xu Jisheng , Zhang Dandan , Zhang Jiyang , Li Lijuan
Published: May 2023

Polyethylene (PE) is widely used in pipeline transportation owing to its excellent corrosion resistance, good stability, and ease of processing. As organic polymer materials, PE pipes inevitably undergo different degrees of aging during long-term use. In this study, terahertz time-domain spectroscopy was used to study the spectral characteristics of PE pipes with different degrees of photothermal aging, and the variation in the absorption coefficient with aging time was obtained. The absorption coefficient spectrum was extracted using uninformative variable elimination (UVE), successive projections algorithm (SPA), competitive adaptive reweighted sampling (CARS), and random frog RF spectral screening algorithms, and the spectral slope characteristics of the aging-sensitive band were selected as the evaluation indices of the degree of PE aging. Based on this, a partial least squares aging characterization model was established to predict white PE80, white PE100 and black PE100 pipes with different aging degrees. The results showed that the prediction accuracy of the absorption coefficient spectral slope feature prediction model for the aging degree of different types of pipes was greater than 93.16% and the verification set error was within 13.5 h.
Effects of Ambient Temperature and State of Galvanized Layer on Corrosion of Galvanized Steel in High-Humidity Neutral Atmosphere
Authors: Liang Yusong , He Bin , Fu Guo , Wu Shoujun , Fan Bin
Published: May 2023

Galvanized steel is a cost-effective and corrosion-resistant material with high strength, making it a popular choice for various engineering applications. In order to investigate the effects of ambient temperature and galvanized layer state on the corrosion of galvanized steel in a high-humidity neutral atmosphere environment, we placed three types of specimens (Q235 steel, undamaged galvanized steel, damaged galvanized steel) in a neutral atmosphere environment with a humidity of 95% at three different temperatures (50 °C, 70 °C, and 90 °C) for testing. The corrosion behavior of specimens under simulated high-temperature and high-humidity conditions was studied using weight changes, macroscopic and microscopic observations, and analysis of the corrosion products of the specimens before and after corrosion. Emphasis was placed on examining the effects of temperature and damage to the galvanized layer on the corrosion rate of the specimens. The findings indicated that damaged galvanized steel retains good corrosion resistance at 50 °C. However, at 70 °C and 90 °C, the damage to the galvanized layer will accelerate the corrosion of the base metal.
Modelling of Electro-Viscoelastic Materials through Rate Equations
Authors: Giorgi Claudio , Morro Angelo
Published: May 2023

Models of dielectric solids subject to large deformations are established by following a thermodynamic approach. The models are quite general in that they account for viscoelastic properties and allow electric and thermal conduction. A preliminary analysis is devoted to the selection of fields for the polarization and the electric field; the appropriate fields are required to comply with the balance of angular momentum and to enjoy the Euclidean invariance. Next, the thermodynamic restrictions for the constitutive equations are investigated using a wide set of variables allowing for the joint properties of viscoelastic solids, electric and heat conductors, dielectrics with memory, and hysteretic ferroelectrics. Particular attention is devoted to models for soft ferroelectrics, such as BTS ceramics. The advantage of this approach is that a few constitutive parameters provide a good fit of material behaviour. A dependence on the gradient of the electric field is also considered. The generality and the accuracy of the models are improved by means of two features. The entropy production is regarded as a constitutive property per se, while the consequences of the thermodynamic inequalities are made explicit by means of representation formulae.
Novel Functional Soft Magnetic CoFe2O4/Fe Composites: Preparation, Characterization, and Low Core Loss
Authors: Li Shigeng , Wang Xianzhong , Ouyang Fangping , Liu Rutie , Xiong Xiang
Published: May 2023

In this study, composites CoFe2O4/Fe were successfully synthesized by in situ oxidation, and their composition, structure, and magnetic properties have been investigated. According to the analysis of X-ray photoelectron spectrometry measure results, the cobalt ferrite insulating layer was completely coated on the surface of Fe powder particles. The evolution of the insulating layer during the annealing process has been discussed, which is correlated to effects on the magnetic properties of the composites CoFe2O4/Fe. The amplitude permeability of the composites reached a maximum of 110, and their frequency stability reached 170 kHz with a relatively low core loss of 253.6 W/kg. Therefore, the composites CoFe2O4/Fe has potential application in the field of integrated inductance and high-frequency motor, which is conducive to energy conservation and carbon reduction.
Experimental Study on the Performance of Steel-Fiber-Reinforced Concrete for Remote-Pumping Construction
Authors: Zhao Minglei , Li Changyong , Li Jie , Yue Lixian
Published: May 2023

Remote-pumped concrete for infrastructure construction is a key innovation of the mechanized and intelligent construction technology. This has brought steel-fiber-reinforced concrete (SFRC) into undergoing various developments, from conventional flowability to high pumpability with low-carbon features. In this regard, an experimental study on the mixing proportion design and the pumpability and mechanical properties of SFRC was conducted for remote pumping. Using the absolute volume method based on the steel-fiber-aggregate skeleton packing test, the water dosage and the sand ratio were adjusted with an experimental study on reference concrete with the premise of varying the volume fraction of steel fiber from 0.4% to 1.2%. The test results of the pumpability of fresh SFRC indicated that the pressure bleeding rate and the static segregation rate were not the controlling indices due to the fact that they were far below the limits of the specifications, and the slump flowability fitted for remote-pumping construction was verified by a lab pumping test. Although the rheological properties of the SFRC charactered by the yield stress and the plastic viscosity increased with the volume fraction of steel fiber, those of mortar used as a lubricating layer during the pumping was almost constant. The cubic compressive strength of the SFRC had a tendency to increase with the volume fraction of steel fiber. The reinforcement effect of steel fiber on the splitting tensile strength of the SFRC was similar to the specifications, while its effect on the flexural strength was higher than the specifications due to the special feature of steel fibers distributed along the longitudinal direction of the beam specimens. The SFRC had excellent impact resistance with an increased volume fraction of steel fiber and presented acceptable water impermeability.
Oblique Crashworthiness Analysis of Steel Circular Tubes: Parametric Study on Wall Thickness Effect and Critical Loading Angle Identification
Authors: Karantza Konstantina D. , Papantoniou Ioannis G. , Lykakos Stavros S. A. , Manolakos Dimitrios E.
Published: May 2023

The current work studied the crashworthiness behavior of thin-walled circular steel tubes against axial and oblique crushing. Parametric analyses of crushing angle and tube wall thickness were conducted aiming to identify their effect on dissipated energy, collapse initiation and deformation stability. Quasi-static experiments and finite element (FE) simulations in LS-DYNA were implemented for crushing angle parametric analysis, while the wall thickness effect was studied numerically for the same loading angle range. Both experiments and simulations revealed that an increase in crushing angle results in lower energy absorption (EA) and peak force. Low-angled oblique loading was indicated as the most efficient impact condition reaching sufficient EA and facilitating plastic collapse initiation. The occurrence of global bending mode revealed a critical loading angle value reacting to a significant EA drop due to unstable plastic deformation. Finally, higher wall thickness resulted in greater peak force and increased critical angle reacting to a smoother EA decrease with respect to loading angle by preventing unstable deformation mode.
Differential and Time-Discrete SEIRS Models with Vaccination: Local Stability, Validation and Sensitivity Analysis Using Bulgarian COVID-19 Data
Authors: Margenov Svetozar , Popivanov Nedyu , Ugrinova Iva , Hristov Tsvetan
Published: May 2023

Bulgaria has the lowest COVID-19 vaccination rate in the European Union and the second-highest COVID-19 mortality rate in the world. That is why we think it is important better to understand the reason for this situation and to analyse the development of the disease over time. In this paper, an extended time-dependent SEIRS model SEIRS-VB is used to investigate the long-term behaviour of the COVID-19 epidemic. This model includes vaccination and vital dynamics. To apply the SEIRS-VB model some numerical simulation tools have been developed and for this reason a family of time-discrete variants are introduced. Suitable inverse problems for the identification of parameters in discrete models are solved. A methodology is proposed for selecting a discrete model from the constructed family, which has the closest parameter values to these in the differential SEIRS-VB model. To validate the studied models, Bulgarian COVID-19 data are used. To obtain all these results for the discrete models a mathematical analysis is carried out to illustrate some biological properties of the differential model SEIRS-VB, such as the non-negativity, boundedness, existence, and uniqueness. Using the next-generation method, the basic reproduction number associated with the model in the autonomous case is defined. The local stability of the disease-free equilibrium point is studied. Finally, a sensitivity analysis of the basic reproduction number is performed.
Criteria on Exponential Incremental Stability of Dynamical Systems with Time Delay
Authors: Lang Yingying , Lu Wenlian
Published: May 2023

Incremental stability analysis for time-delay systems has attracted more and more attention for its contemporary applications in transportation processes, population dynamics, economics, satellite positions, etc. This paper researches the criteria for exponential incremental stability for time-delay systems with continuous or discontinuous right-hand sides. Firstly, the sufficient conditions for exponential incremental stability for time-delay systems with continuous right-hand sides are studied, and several corollaries for specific cases are provided. As for time-delay systems with discontinuous right-hand sides, after expounding the relevant conditions for the existence and uniqueness of the Filippov solution, by using approximation methods, sufficient conditions for exponential incremental stability are obtained. The conclusions are applied to linear switched time-delay systems and Hopfield neural network systems with composite right-hand sides.
Cut-Off Value of Voluntary Peak Cough Flow in Patients with Parkinson’s Disease and Its Association with Severe Dysphagia: A Retrospective Pilot Study
Authors: Lee Kyeong-Woo , Kim Sang-Beom , Lee Jong-Hwa , Kim Seong-Woo
Published: May 2023

Background and Objectives. Swallowing and coughing reflexes are both closely associated with airway protection. Peak cough flow (PCF) is associated with dysphagia in several neurogenic diseases. In this study, we aimed to analyze the relationship between PCF and aspiration in Parkinson’s disease (PD) and determine the cut-off value of PCF. Materials and Methods. We retrospectively analyzed the records of patients with PD who underwent a videofluoroscopic swallowing study and checked for PCF. A total of 219 patients were divided into an aspiration group (n = 125) and a non-aspiration group (n = 94). Results. Significantly lower PCF values were observed in the aspiration group compared to the non-aspiration group (132.63 ± 83.62 vs. 181.38 ± 103.92 L/min, p < 0.001). Receiver operating characteristic curve analysis revealed that a PCF cut-off value of 153 L/min (area under the receiver operating characteristic curve, 0.648; sensitivity, 73.06%; specificity, 51.06%) was associated with aspiration in PD. Additionally, a univariate analysis showed that the male sex, lower body mass indexes, higher Hoehn and Yahr scales, and PCF values of ≤153 L/min indicated an increased risk of aspiration. Conclusions. Through a multivariate analysis, we demonstrated that a PCF value ≤153 L/min was associated with an increased risk of aspiration (odds ratio 3.648; 1.797–7.407), highlighting that a low PCF is a risk factor for aspiration in patients with PD.
Modal-Transition-Induced Valleys of K2 in Piezoelectric Bilayer Laterally Vibrating Resonators
Authors: Xie Zihao , Sun Jiabao , Xie Jin
Published: May 2023

Piezoelectric Laterally Vibrating Resonators (LVRs) have attracted significant attention as a potential technology for next-generation wafer-level multi-band filters. Piezoelectric bilayer structures such as Thin-film Piezoelectric-on-Silicon (TPoS) LVRs which aim to increase the quality factor (Q) or aluminum nitride and silicon dioxide (AlN/SiO2) composite membrane for thermal compensation have been proposed. However, limited studies have investigated the detailed behaviors of the electromechanical coupling factor (K2) of these piezoelectric bilayer LVRs. Herein, AlN/Si bilayer LVRs are selected as an example, we observed notable degenerative valleys in K2 at specific normalized thicknesses using two-dimensional finite element analysis (FEA), which has not been reported in the previous studies of bilayer LVRs. Moreover, the bilayer LVRs should be designed away from the valleys to minimize the reduction in K2. Modal-transition-induced mismatch between electric and strain fields of AlN/Si bilayer LVRs are investigated to interpret the valleys from energy considerations. Furthermore, the impact of various factors, including electrode configurations, AlN/Si thickness ratios, the Number of Interdigitated Electrode (IDT) Fingers (NFs), and IDT Duty Factors (DFs), on the observed valleys and K2 are analyzed. These results can provide guidance for the designs of piezoelectric LVRs with bilayer structure, especially for LVRs with a moderate K2 and low thickness ratio.