bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of a fractured humerus and partially torn supraspinatus tendon in a professional boxer with liquid platelet-rich fibrin and heat-coagulated albumin gel: a case report
Authors: Ogéus Torbjörn
Published: March 2024

Introduction

Fractures with delayed healing can be a serious complication, especially for athletes depending on quick return to sports. To our knowledge, no cases of increased healing of delayed union fractures with autologous biomedical interventions have been reported.

Case presentation

A 33-year-old Swedish professional boxer with a fractured humerus with a delayed union and a partially torn supraspinatus tendon was treated with injections of liquid platelet-rich fibrin and heat-coagulated albumin gel. He recovered almost completely from both injuries in only 1 month and could return to professional boxing in 3 months.

Conclusion

This case raises the hypothesis that liquid platelet-rich fibrin and heat-coagulated albumin gel may be an effective, minimally invasive intervention in fractures with a delayed union. Further research is required to test this theory.
Primary alveolar rhabdomyosarcoma of the brain: a case report
Authors: Al Mahmasani Layal , Najjar Marwan , Hourany Roula , Tabbarah Abeer , Sinno Sara , Chamseddine Nathalie , Abou Zeidane Reine , Amhaz Ghid , Youssef Bassem , Assi Hazem I.
Published: March 2024

Background

Primary brain rhabdomyosarcoma is a rare primary brain malignancy with few case reports. The vast majority of cases of primary brain rhabdomyosarcoma occur in pediatric patients, and immunohistochemistry can distinguish it from embryonal subtypes; however, few cases of primary brain rhabdomyosarcoma in adults have been reported in the literature.

Case presentation

We report the case of a 26-year-old White male patient who was found to have primary brain alveolar rhabdomyosarcoma after developing headaches for several months. A brain MRI revealed a mixed cystic and solid tumor along the vermis of the cerebellum. The patient underwent a gross total surgical resection, which confirmed the diagnosis of alveolar rhabdomyosarcoma. Further staging workup for another primary focus or disseminated disease yielded negative results, confirming the diagnosis of primary alveolar rhabdomyosarcoma of the brain.

Conclusion

The standard of care for managing this rare type of brain tumor involves surgery with adjuvant chemoradiotherapy. Further studies should be conducted for a better diagnostic and therapeutic understanding.
Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc
Authors: Williams Jason S. , Higgins Adam T. , Stott Katie J. , Thomas Carly , Farrell Lydia , Bonnet Cleo S. , Peneva Severina , Derrick Anna V. , Hay Trevor , Wang Tianqi , Morgan Claire , Dwyer Sarah , D’Ambrogio Joshua , Hogan Catherine , Smalley Matthew J. , Parry Lee , Dyson Paul
Published: March 2024

Background

Bacterial cancer therapy was first trialled in patients at the end of the nineteenth century. More recently, tumour-targeting bacteria have been harnessed to deliver plasmid-expressed therapeutic interfering RNA to a range of solid tumours. A major limitation to clinical translation of this is the short-term nature of RNA interference in vivo due to plasmid instability. To overcome this, we sought to develop tumour-targeting attenuated bacteria that stably express shRNA by virtue of integration of an expression cassette within the bacterial chromosome and demonstrate therapeutic efficacy in vitro and in vivo.

Results

The attenuated tumour targeting Salmonella typhimurium SL7207 strain was modified to carry chromosomally integrated shRNA expression cassettes at the xylA locus. The colorectal cancer cell lines SW480, HCT116 and breast cancer cell line MCF7 were used to demonstrate the ability of these modified strains to perform intracellular infection and deliver effective RNA and protein knockdown of the target gene c-Myc. In vivo therapeutic efficacy was demonstrated using the Lgr5creERT2Apcflx/flx and BlgCreBrca2flx/flp53flx/flx orthotopic immunocompetent mouse models of colorectal and breast cancer, respectively. In vitro co-cultures of breast and colorectal cancer cell lines with modified SL7207 demonstrated a significant 50–95% (P < 0.01) reduction in RNA and protein expression with SL7207/c-Myc targeted strains. In vivo, following establishment of tumour tissue, a single intra-peritoneal administration of 1 × 106 CFU of SL7207/c-Myc was sufficient to permit tumour colonisation and significantly extend survival with no overt toxicity in control animals.

Conclusions

In summary we have demonstrated that tumour tropic bacteria can be modified to safely deliver therapeutic levels of gene knockdown. This technology has the potential to specifically target primary and secondary solid tumours with personalised therapeutic payloads, providing new multi-cancer detection and treatment options with minimal off-target effects. Further understanding of the tropism mechanisms and impact on host immunity and microbiome is required to progress to clinical translation.
The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
Authors: Gandhi Pranali , Wang Yuzhi , Li Guigang , Wang Shusheng
Published: March 2024

Background

Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible for various vascular oculopathies, including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, and corneal neovascularization. While anti-VEGF treatment is available, it is not curative, and long-term outcomes are suboptimal, and some patients are unresponsive.

Results and summary

To better understand these diseases, researchers have investigated the role of lncRNAs in regulating angiogenesis and models of vascular oculopathies. This review summarizes recent research on lncRNAs in ocular angiogenesis, including the pro-angiogenic lncRNAs ANRIL, HOTAIR, HOTTIP, H19, IPW, MALAT1, MIAT, NEAT1, and TUG1, the anti-angiogenic lncRNAs MEG3 and PKNY, and the human/primate specific lncRNAs lncEGFL7OS, discussing their functions and mechanisms of action in vascular oculopathies.
Mechanisms behind gender transformative approaches targeting adolescent pregnancy in low- and middle-income countries: a realist synthesis protocol
Authors: Shukla Shruti , Abejirinde Ibukun-Oluwa Omolade , Meyer Sarah R. , Shenderovich Yulia , Steinert Janina Isabel
Published: March 2024

Introduction

Adolescent pregnancy is defined as pregnancy at the age of 19 or below. Pregnancy and childbirth complications are the most significant cause of death among 15–19-year-old girls. Several studies have indicated that inequitable gender norms can increase the vulnerability of adolescent girls, including violence exposure, early marriage, and adolescent pregnancy. To address these disparities, gender transformative approaches aim to challenge and transform restrictive gender norms, roles, and relations through targeted interventions, promoting progressive changes. This realist review aims to synthesise existing evidence from a broad range of data sources to understand how, why, for whom, and in what contexts gender transformative approaches succeed in reducing adolescent pregnancy in low- and middle-income countries.

Method and analysis

We employ a five-step realist synthesis approach: (1) clarify the scope of review and assessment of published literature, (2) development of initial programme theories, (3) systematic search for evidence, (4) development of refined programme theories, and (5) expert feedback and dissemination of results. This protocol presents the results of the first three steps and provides details of the next steps.

We extracted data from 18 studies and outlined eight initial programme theories on how gender transformative approaches targeting adolescent pregnancy work in the first three steps. These steps were guided by experts in the field of sexual and reproductive health, implementation science, and realist methodology. As a next step, we will systematically search evidence from electronic databases and grey literature to identify additional studies eligible to refine the initial programme theories. Finally, we will propose refined programme theories that explain how gender transformative approaches work, why, for whom, and under which circumstances.

Ethics and dissemination

Ethics approval is not required because the included studies are published articles and other policy and intervention reports. Key results will be shared with the broader audience via academic papers in open-access journals, conferences, and policy recommendations. The protocol for this realist review is registered in PROSPERO (CRD42023398293).
Clinicopathological and molecular genetic alterations in monomorphic–epitheliotropic intestinal T-cell lymphoma of the small intestine
Authors: Zhou Bing , Guo Min , Li Xiaohua , Duan Ting , Peng Lizi , Hao Hua
Published: March 2024

Background

Small intestinal monomorphic–epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell lymphoma originating in the gastrointestinal tract. This study aimed to investigate the clinicopathological features, immunophenotypes, and molecular genetic changes of MEITL.

Methods

The clinicopathological data for three patients with surgically resected MEITL of the small intestine were collected. Next, immunohistochemical labeling, Epstein–Barr virus (EBV) in situ hybridization, assessment of clonal rearrangement of T-cell receptor (TCR) genes, and next-generation sequencing (NGS) were performed.

Results

Of the three patients, two were male and one was female, with ages of 61, 67, and 73 years, respectively. Clinical manifestations were predominantly abdominal pain and distension. Histopathology revealed infiltrative growth of small-to-medium-sized lymphocytes with a consistent morphology between the intestinal walls, accompanied by an obvious pro-epithelial phenomenon. The expression of CD3, CD8, CD43, CD56, TIA-1, CD103, H3K36me3, and Bcl-2 was detected, and the Ki-67 proliferation index ranged from 50% to 80%. All three patients tested negative for EBER. However, monoclonal rearrangement of the TCR gene was detected in them. NGS testing showed a JAK3 mutation in all three cases. Further, STAT5B, SETD2, and TP53 mutations were each observed in two cases, and a BCOR mutation was found in one case. All patients were treated with chemotherapy after surgery. Two patients died 7 and 15 month post-operation, and one patient survived for 5 months of follow-up.

Conclusions

Our findings demonstrate that mutations in JAK3 and STAT5B of the JAK/STAT pathway and inactivation of the oncogene SETD2 markedly contribute to the lymphomagenesis of MEITL.
Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station
Authors: Sengupta Pratyay , Muthamilselvi Sivabalan Shobhan Karthick , Singh Nitin Kumar , Raman Karthik , Venkateswaran Kasthuri
Published: March 2024

Background

The International Space Station (ISS) stands as a testament to human achievement in space exploration. Despite its highly controlled environment, characterised by microgravity, increased CO$$_{2}$$

2

levels, and elevated solar radiation, microorganisms occupy a unique niche. These microbial inhabitants play a significant role in influencing the health and well-being of astronauts on board. One microorganism of particular interest in our study is Enterobacter bugandensis, primarily found in clinical specimens including the human gastrointestinal tract, and also reported to possess pathogenic traits, leading to a plethora of infections.

Results

Distinct from their Earth counterparts, ISS E. bugandensis strains have exhibited resistance mechanisms that categorise them within the ESKAPE pathogen group, a collection of pathogens recognised for their formidable resistance to antimicrobial treatments. During the 2-year Microbial Tracking 1 mission, 13 strains of multidrug-resistant E. bugandensis were isolated from various locations within the ISS. We have carried out a comprehensive study to understand the genomic intricacies of ISS-derived E. bugandensis in comparison to terrestrial strains, with a keen focus on those associated with clinical infections. We unravel the evolutionary trajectories of pivotal genes, especially those contributing to functional adaptations and potential antimicrobial resistance. A hypothesis central to our study was that the singular nature of the stresses of the space environment, distinct from any on Earth, could be driving these genomic adaptations. Extending our investigation, we meticulously mapped the prevalence and distribution of E. bugandensis across the ISS over time. This temporal analysis provided insights into the persistence, succession, and potential patterns of colonisation of E. bugandensis in space. Furthermore, by leveraging advanced analytical techniques, including metabolic modelling, we delved into the coexisting microbial communities alongside E. bugandensis in the ISS across multiple missions and spatial locations. This exploration revealed intricate microbial interactions, offering a window into the microbial ecosystem dynamics within the ISS.

Conclusions

Our comprehensive analysis illuminated not only the ways these interactions sculpt microbial diversity but also the factors that might contribute to the potential dominance and succession of E. bugandensis within the ISS environment. The implications of these findings are twofold. Firstly, they shed light on microbial behaviour, adaptation, and evolution in extreme, isolated environments. Secondly, they underscore the need for robust preventive measures, ensuring the health and safety of astronauts by mitigating risks associated with potential pathogenic threats.
MicroRNA-148b secreted by bovine oviductal extracellular vesicles enhance embryo quality through BPM/TGF-beta pathway
Authors: Cañón-Beltrán Karina , Cajas Yulia N , Almpanis Vasileios , Egido Sandra Guisado , Gutierrez-Adan Alfonso , González Encina M , Rizos Dimitrios
Published: March 2024

Background

Extracellular vesicles (EVs) and their cargoes, including MicroRNAs (miRNAs) play a crucial role in cell-to-cell communication. We previously demonstrated the upregulation of bta-mir-148b in EVs from oviductal fluid of cyclic cows. This miRNA is linked to the TGF-β pathway in the cell proliferation. Our aim was to verify whether miR-148b is taken up by embryos through gymnosis, validate its target genes, and investigate the effect of miR-148b supplementation on early embryo development and quality.

Methods

Zygotes were cultured in SOF + 0.3% BSA (Control) or supplemented with: 1 µM miR-148b mimics during: D1-D7 (miR148b) or D1-D4 (miR148b-OV: representing miRNA effect in the oviduct) or D4-D7 (miR148b-UT: representing miRNA effect in the uterus) or 1 µM control mimics was used during: D1-D7 (CMimic). Embryos at ≥ 16-cells and D7 blastocysts (BD7) were collected to examine the mRNA abundance of transcripts linked to the TGF-β pathway (TGFBR2, SMAD1, SMAD2, SMAD3, SMAD5, BMPR2, RPS6KB1, POU5F1, NANOG), total cell number (TC), trophectoderm (TE), and inner cell mass (ICM) were also evaluated. One-way ANOVA was used for all analyses.

Results

We demonstrated that miR-148b can be taken up in both 16-cell embryos and BD7 by gymnosis, and we observed a decrease in SMAD5 mRNA, suggesting it’s a potential target of miR-148b. Cleavage and blastocysts rates were not affected in any groups; however, supplementation of miR-148b mimics had a positive effect on TC, TE and ICM, with values of 136.4 ± 1.6, 92.5 ± 0.9, 43.9 ± 1.3 for miR148b and 135.3 ± 1.5, 92.6 ± 1.2, 42.7 ± 0.8, for miR148b-OV group. Furthermore, mRNA transcripts of SMAD1 and SMAD5 were decreased (P ≤ 0.001) in 16-cell embryos and BD7 from miR148b and miR148b-OV groups, while POU5F1 and NANOG were upregulated (P ≤ 0.001) in BD7 and TGFBR2 was only downregulated in 16-cell embryos. pSMAD1/5 levels were higher in the miR148b and miR148b-OV groups.

Conclusions

Our findings suggest that supplementation of bta-miR-148b mimics during the entire culture period (D1 - D7) or from D1 - D4 improves embryo quality and influences the TGF-β signaling pathway by altering the transcription of genes associated with cellular differentiation and proliferation. This highlights the importance of miR-148b on embryo quality and development.
Conventional and molecular cytogenetic characterization of a Moroccan patient with WAGR syndrome
Authors: Chbel Faiza , Hamdaoui Hasna , Mossafa Houssein , Ouldim Karim , Benrahma Houda
Published: March 2024

Background

WAGR syndrome is a rare genetic disorder characterized by a de novo deletion of 11p13 and is usually clinically associated with Wilms’ tumor, aniridia, genitourinary anomalies, and mental retardation (W-A-G-R). Although the genotypic defects in WAGR syndrome have been well established. The congenital aniridia is caused, in nearly 90% of cases by mutations in the gene PAX6. In the face of congenital aniridia, it is imperative to specify whether it falls within the scope of a WAGR syndrome or if it is an isolated congenital aniridia or inherited by performing karyotype, FISH (Fluorescence In Situ Hybridization) or a CGH array for genetic counseling.

Case presentation

We report here a case of genetic testing for newborn with aniridia, to detect 11p13 rearrangements, using karyotyping and CGH array to complete picture of the chromosomal deletions and breakpoints in aniridia. Results show either a loss of 3811.196 kb on chromosome 11 delimited by the bands p14.1 and p13 with formula or a loss of a 1867.287 kb on chromosome 18 fragment delimited by q21.33 and q22.1 bands, that has not been detected by karyotype analysis.

Conclusions

Cytogenetics screening is a good strategy for the genetic diagnosis of aniridia and associated syndromes, allowing for a better identification of breakpoints. Our results underline the clinical importance of performing exhaustive and accurate analysis of chromosomal rearrangements for patients with aniridia, especially newborns to improve survival and quality of life for affected individuals.
Von Duden bis Deepl: zur Verwendung lexikografischer Ressourcen im Südtiroler Sprachunterricht (L1, L2, L3) im Spannungs-feld normativer Vorgaben und schulischer Praxis
Authors: Abel Andrea
Published: March 2024

The paper deals with the role of lexicographic resources in the South Tyrolean (i. e. the Autonomous Province of Bolzano/Bozen, Italy) educational context against the backdrop of legal provisions (Das neue Autonomiestatut 2019/1972) and the relevance of language education on the part of educational institutions (Rahmenrichtlinien DE, Rahmenrichtlinien IT), taking into account both normative requirements and their application in practice. The focus is on two questions that have been little researched so far, not only in the specific context but also internationally (cf. Abel 2022; Nied Curcio 2022): To what extent are lexicographic resources represented in the school framework guidelines? How are they actually used in schools? For the case study presented here, the South Tyrolean framework guidelines provided by the German and the Italian school boards at all levels of education for German and Italian as first (L1) and second (L2) languages, as well as for English as a foreign language (L3) were examined by means of a document analysis. In a second step, a questionnaire survey with language teachers at all school levels (German and Italian as L1/L2, English as L3; number of survey respondents: 644) determined the actual use of lexicographic resources.
In search of a prerequisite for infant participation in pregnancy: a depth-hermeneutical interpretation of conversations between coming mothers and midwives
Authors: Bakkenget Brynulf , Finholt-Pedersen Sissel Merete , Håkansson Ulrika Christina , Våpenstad Eystein Victor
Published: March 2024

Based on the fact that the United Nations Convention on the Rights of the Child (UNCRC) gives the right to participate and be heard in situations that affect their lives to all children, even pre-verbal infants, we have looked for the infant voice in parental narratives about their child. Conversations between 16 mothers and a professional at two stages were videotaped and transcribed. The first conversation between mother and midwife took place in pregnancy and, the second, between mother and health nurse, was completed when the child was about six months old. We wanted to invent a method that could find the voice of pre-verbal children, even before birth, a method capable of registering the child’s impact on us and decoding this influence into common language and practical action. Based on infant research on intersubjectivity and qualitative methodology from psychosocial research, we developed a procedure of depth-hermeneutical interpretation of the parental narratives. In this article we describe the results from the interpretation of the narratives made in pregnancy. Through the procedure of Scenic-Narrative Microanalysis, a very suitable method of depth-hermeneutic group interpretation, we identified three different areas of conflict or tension in the data material: container versus oneness; openness versus narrowness; and control versus curiosity. A description of the epistemological foundations and the research procedures from data collection to interpretation will be given.

The results from the second round of interpretation will be analysed and compared with the results from the pregnancy narratives, and published in a future article.
Tense and Lax Vowels in the Lahu Dialect of Yunshan: A Laboratory Phonological Study
Authors: Liu Yan , Wei Yichen , Luo Yongxian
Published: March 2024

A controversy exists regarding whether there are tense-lax vowels in Lahu and whether tense-lax phonation should be accorded phonological status, an issue that is closely related to the physiological movement of the larynx. This study presents an experimental analysis of the acoustic features of the Lahu dialect of Yunshan, using electroglottography to collect acoustic and physiological data and employing VoiceSauce and Eggworks to extract glottal features to explore laryngeal mode of motion. The study demonstrates a distinct tense-lax phonation contrast in Yunshan Lahu, which is characterized by multiple types of phonation, differences between front and back parts of tense vowels, and equal importance of tense-lax contrast and vowel length. To contribute to a systematic description of Tibeto-Burman language, this paper proposes to treat tense-lax contrast as the main feature in phonological induction, using length as its accompanying feature for explanation. From the perspective of the path of historical evolution, tenseness comes from the loss of plosive codas, and is also closely related to voiced, aspirated initials. In the process of transforming tense-lax features to tones, tense vowels retained their features of tenseness as a result of falling tones.
A Prosodic and Perceptional Study on the Chinese Interrogative Pronoun “Shen Me” When Indicating Inquiry, Free Reference and Negation (in Chinese)
Authors: Wang Ping , Wang Xiaowen
Published: March 2024

This paper makes a comprehensive investigation and comparison of the prosodic and perceptual performance of the interrogative pronoun " shen me " when indicating question, free reference and negation. The results show that the prosodic performance of the sentence using " shen me " to indicate a question is similar to the prosody of an interrogative sentence; the sentence using " shen me " to indicate free reference has the intonation of a declarative sentence with the focus stress on “ dou ”; and the sentence using " shen me " to indicate negation has the intonation of an exclamatory sentence with focus stress on " shen me " or the predicative verb “ suan ”. The results of these perceptual experiments show that the acoustic differences of " shen me " won’t affect the listener’s judgement of the mood of the original sentence, but will affect the judgement of its naturalness to a certain extent. Combining acoustic and perceptual performance, “shen me” indicating a question and free reference carries natural stress, and " shen me " indicating negation carries emphatic stress. The three functions of " shen me " should be discriminated using multi-dimensional standards, that is, both prosody and perception. Additionally, the prosodic standard should include pitch, duration and intensity.
An Ongoing Tonal-Pattern Change: Lanzhou Dialect
Authors: Yi Li , Li Han , Li Yingyi , Mu Juejue
Published: March 2024

The tonal-pattern of Lanzhou dialect is experiencing a change demonstrated in two aspects: a) Yin-ping 阴平 (T1a) has two variants, falling and level, and the former is being replaced by the latter; b) Shang-sheng 上声 (T2) and Qu-sheng 去声 (T3) are merging. We propose that the tonal change of T1a is partially a result of language contact, and the sandhi T1a from initial position of disyllabic combination also plays a role in extending the level tone to the citation T1a, the change of T1a then further triggers the merger of T2 and T3. Yet whether it is the change of sandhi T1a in the initial position or the change of the surface representation of citation T1a, or the merger of T2 and T3, all the directionality of tonal change is in line with the “clockwise tone shift circle” (Zhu et al. 2015; Yang and Xu 2019). We argue that tone changes are mainly due to internal factors. Although there are external stimuli, the path of tone change follows rules. The illustration of the ongoing tonal-pattern change in Lanzhou dialect will shed light on the understanding of the rules.
Far-red, high-resolution, reflection-free images of the anterior segment in retroillumination
Authors: AIN Anthony , Poinard Sylvain , Lepine Thierry , Dorado-Cortez Oliver , Urbaniak Sébastien , Papillon Jean-Marie , Gain Philippe , Thuret M Gilles
Published: March 2024

While retro-illumination of the anterior segment is part of the routine examination in ophthalmology, capturing a quality image is very difficult. We have therefore developed a new imaging device by modifying a slit lamp. By using a far-red light source, a monochrome sensor and modifications to the optical path, we were able to obtain high-resolution images, without reflection and without dazzling the patient. Here, for the first time, we present a number of potential applications for this revisited imaging technique.
On fixed point convergence results for class of nonexpansivemappings in hyperbolic spaces via PJ iteration process
Authors: Shrivas Jaynendra , Verma Rohit Kumar , Chandraker Priya
Published: March 2024

In this paper, we provide certain fixed point results for a mean nonexpansive mapping, as well as a new iterative algorithm called PJ-iterationfor approximating the fixed point of this class of mappings in the setting of hyperbolic spaces. Furthermore, we establish strong and∆-convergence theorem for mean nonexpansive mapping in hyperbolic space. Finally, we present a numerical example to illustrate ourmain result and then display the efficiency of the proposed algorithm compared to different iterative algorithms in the literature. Our resultsobtained in this paper improve, extend and unify some related results in the literature.
Similarity Aspects of Cultural Values Between Indonesia and New Zealand in Early Childhood Education Stated in Curriculum Policies
Authors: Kamil Nurhusna , Intan Permata Putri  , Kulsum Nur Hayati
Published: March 2024

This study will discuss the similarities between cultural values in early childhood learning in Indonesia and New Zealand which are outlined in the curricula of both countries. The countries primarily care for children's education which clearly highlights every aspect of their development, in that the cultural values have been explicitly incorporated into the curriculum. This study is library research because it explores written resources of documents and the curriculum. The result of the study indicated that both countries believe that values of the local culture are important to instill in children through curriculum. The Indonesian curriculum, which has committed to innovation now and then, strongly emphasizes the cultural values of Pancasila in every aspect of children's education. Meanwhile, New Zealand introduced “Te Whariki” values to children in the learning process in class.
Abstrak
Penelitian ini akan membahas kesamaan antara nilai-nilai budaya dalam pembelajaran anak usia dini (PAUD) di Indonesia dan Selandia Baru yang dituangkan dalam kurikulum kedua negara. Kedua negara ini sangat peduli terhadap pendidikan anak-anak yang dengan jelas menyoroti setiap aspek perkembangan mereka karena nilai-nilai budaya kedua negara ini telah secara eksplisit dimasukkan dalam kurikulum. Penelitian ini adalah penelitian kepustakaan karena mengeksplorasi sumber tertulis dokumen, kurikulum. Hasil penelitian menunjukkan bahwa kedua negara percaya bahwa nilai-nilai budaya lokal penting untuk ditanamkan pada anak-anak melalui kurikulum. Kurikulum Indonesia yang saat ini berkomitmen terhadap inovasi yang sangat menekankan nilai-nilai budaya Pancasila dalam setiap aspek pendidikan anak. Sementara itu, Selandia Baru memperkenalkan nilai-nilai "Te Whariki" kepada anak-anak dalam proses pembelajaran di kelas.
Information System Development for Reading and Writing Qur'an at Tarbiyah and Teacher Training Faculty of UIN Sunan Kalijaga
Authors: Nur Hidayat  , Kasyful Albab Al Musthofa  , Adhi Setiyawan
Published: March 2024

Some Postgraduate and Doctoral Alumni of UIN Sunan Kalijaga, Faculty of Tarbiyah Sciences do not yet have Quranic literacy skills, so the Faculty of Tarbiyah and Teacher Training held standardization for students who will graduate by adding conditions to be able to take part in the munaqasah session by passing the Quran Literacy Exam. This research uses the plomp method and the assure method because it can simplify the stages systematically. The results of this quranic literacy examination research graduates from postgraduate or doctoral from the faculty of tarbiyah science and teacher training can read and write the Quran all and make student output better than the previous year’.
Abstrak
Beberapa Alumni Pascasarjana dan Doktoral UIN Sunan Kalijaga Fakultas Ilmu Tarbiyah belum memiliki kemampuan baca tulis Alquran, sehingga Fakultas Ilmu Tarbiyah dan Keguruan mengadakan standarisasi bagi mahasiswa yang akan diwisuda dengan menambahkan syarat untuk dapat mengikuti sidang munaqasah yaitu lulus Ujian Baca Tulis Alquran. Penelitian ini menggunakan metode plomp dan metode assure karena dapat menyederhanakan tahapan-tahapan secara sistematis. Hasil dari penelitian ujian baca tulis alquran ini lulusan dari pascasarjana atau doktoral dari fakultas ilmu tarbiyah dan keguruan dapat membaca dan menulis alquran semua dan menjadikan output mahasiswa lebih baik dari tahun sebelumnya
STUDY OF GEOMETRIC UNSHARPNESS PHENOMENON IN WELDED PLATES USING INDUSTRIAL RADIOGRAPHY METHOD
Authors: Cely Mauricio , Sotomayor Verónica , Constante Giovanny , Haro Santiago
Published: March 2024

The purpose of this document is to elucidate the methodology employed in analyzing the impact of unsharpness resulting from an X-ray generator on the assessment of steel welded joints. The presence of unsharpness significantly affects the accuracy of welded joint inspections conducted through industrial radiographic techniques, distorting actual measurements of potential discontinuities within the weld. To address this issue, a series of welded joint testing specimens were fabricated using a Shielded Metal Arc Welding (SMAW) process. Each specimen was intentionally designed to contain simulated discontinuities whose dimensions adhered to the acceptance or rejection criteria outlined in the API 1104 standard. Subsequently, radiographic testing was conducted on each specimen, and the dimensions of the simulated discontinuities captured on the radiographic films were measured using the "ISee!" software, as recommended by the ASTM E1165 standard. Upon comparison of the actual and theoretical measurements, it was observed that the maximum unsharpness along the X-axis was recorded in specimens featuring elongated slag inclusions (ESI), with a value of 0.1948 mm. Conversely, the maximum unsharpness along the Y-axis was attributed to individual porosities (P), with a recorded value of 0.1041 mm.
TESTING PHRAGMITES AUSTRALIS FOR DOUBLE CURVATURE DEPLOYABLE STRUCTURES
Authors: Ferro César Gabriel , Andrade María Mercedes
Published: March 2024

Felix Escrig’s cover for the San Pablo Swimming Pool in Seville is one of the few examples of an actual application of a biaxial mesh of pantographs in Architecture. A structure that can contain space, easily transforming from a planar surface into a double curvature one, is rarely used as a solution to cover grand areas. In addition, most deployable structures use industrialized components with almost negligible dimensional variations. Analyzing Escrig’s structure with help from both physical and digital models, it is possible to understand its mechanical behavior and the changes in mesh morphology during the deployment process. These models showed how the biaxial mesh suffered some important angular deformations due to the rods and nodes adapting to the double-curvature shape during deployment, resulting in rod and node fatigue, which needed to be addressed before adapting the geometry to a heterogeneous material. This paper describes the geometric implications of using common reed (Phragmites australis) in the construction of double curvature deployable structures, examining the behavior of this heterogeneous material if employed on the manufacture of both rods and nodes. Using a scale model built from an adapted design, the geometry of the reed structure was tested. The heterogeneity of the reed required a redesign of the pivots of the blades and the nodes. This redesign showed that it is possible to use common reed for the construction of deployable double-curvature structures if certain mechanical design considerations, detailed as guidelines in this paper, are observed.
SUSTAINABLE ARCHITECTURE APPLIED TO THE DESIGN OF THE HOUSING CORE
Authors: Maldonado Marchán María Elizabeth , Chérrez Rodas Karina Alexandra
Published: March 2024

This article presents the results of research focused on the design of core housing as a product, process, and continuous transformation system, achieved through a unified space, as a recurring solution since the origins of humankind and an alternative for small spaces. The proposal for affordable housing in Cuenca for low-income populations is based on an approach that involves not only the housing solution but also the relationship with people's ways of living, bioclimatic criteria, and the study of a sustainable construction system. Qualitative research methodologies and transdisciplinary workshops were used to create spaces for discussion and verification with the participation of various stakeholders. Therefore, the research work integrated people's ways of living, the use of local materials, and indoor comfort conditions. After tabulating the gathered data, the design of the core housing was carried out, enabling the design to accommodate the ways people live, rather than the other way around. Ultimately, enabling appropriation according to specific needs of diverse family compositions, in addition to a sustainable construction system as an ecological and economical solution.
EXPERIMENTAL EXPLORATIONS WITH DIGITAL FABRICATION FOR PREFABRICATED CONSTRUCTION SYSTEMS
Authors: MENENDEZ LUIS ALBERTO
Published: March 2024

Digital fabrication tools are powerful machines that have opened a new mindset in the whole construction process and have brought a perfect scene for experimental explorations in the prefabricated construction industry. However, it is still an outlier in the Ecuadorian construction industry where it is uncommon to have industrialized techniques and digital manufacturing machinery. Consequently, academia should promote its use by learning, teaching, and experimenting with these tools. Prefabricated construction enhances technology, logistics, assembly methods, and resource optimization. Combining these two leading techniques will reshape the construction process and make a more efficient industry. Digital prefabrication utilizes advanced technology to improve quality, lower costs, and rapidly test new ideas. This article describes the processes and the experimental approach used in two case studies for building concrete prefabricated pieces with digital manufacturing. Concrete was chosen as the material for the research due to its high demand in the local industry. The objective was to prefabricate items, that could work as an entire system, with a high level of optimization for sustainable construction that achieves scale and repeatability. Lastly, it is significant to mention the lack of local references in this area; therefore, these tests explore the capacity of using digital fabrication to build precast concrete panels to create prototypes that will serve as starting points for further research. Keywords: Digital Manufacturing, Prefabrication, Precast Concrete, Experimental explorations, CNC Fabrication, Expanded Polystyrene (EPS), Concrete panel, Rapid Prototyping.
SUSTAINABLE MODULAR PROTOTYPE WITH BAMBOO FOR COMMUNITY CENTERS
Authors: CERRON OYAGUE TANIA MILUSKA , Torres Zules Gonzalo Alberto , Cerrón Estares Andres Cesar
Published: March 2024

This contribution presents the results of research carried out in two areas of the Peruvian Amazon within the framework of two community projects for technology transfer and capacity development in construction with bamboo, with the objective of designing and building a modular prototype with bamboo for 1/1 scale with the function of a community center, capable of incorporating sustainable strategies, replicability and adaptability, as an architectural alternative to the deterioration of the Amazonian natural and cultural habitat. The methodology contemplates two phases of experimentation, the first of design and construction of the Model Prototype in the Southwest Amazon (Pilcopata), studying the local context, the bamboo species, the participatory construction process, to formulate the modular proposal with the function of a Center Tourist Community; the second validation of the Prototype, identifying the bamboo species and adding a module in the design format for use in the Communal Transformation Center in the Central Amazon (Native Community of Pampa Michi), both executed with the local population. Among the results, the efficiency, practicality and flexibility of the design and construction stand out, and the verification of sustainable strategies, with the use of carbon neutral materials such as bamboo, the revaluation of traditional knowledge with palm leaves and the replicability in similar conditions with models of participatory learning, which validate the Prototype. In a third phase, the construction processes are systematized, being part of the Manual for the construction of light structures with bamboo in Peru.
SUSTAINABLE CONSTRUCTION TECHNIQUES WITH BAMBOO AND ICHU STRAW AS A CONTRIBUTION TO ANDEAN ARCHITECTURAL IDENTITY
Authors: CERRON OYAGUE TANIA MILUSKA , CERRON ESTARES ANDRES CESAR , TORRES ZULES GONZALO ALBERTO
Published: March 2024

The present study evaluates the contribution of the use of sustainable construction techniques with plant fibers: bamboo and ichu straw in the architectural identity of Tarma, Junín region. For which the research method considers two phases, in the first, sustainable construction techniques are evaluated and developed, taking into account two dimensions: "the use of local bamboo and ichu straw", with the selection of three species of bamboo from the environment: a native of the genus Chusquea, and two exotics of the genera Guadua and Phillostachys, and the species Stipa ichu; and the “design and application”, with the construction of three architectural models, using the four species, in which the local population participated by adapting traditional weaving techniques with ichu straw. In the second phase, a semi-structured survey is prepared to collect data related to the identity of the local people regarding their territory and the architecture, and the perception and impact generated by the three models. Among the results of the first and second phase, the possibilities of using bamboo as a construction material according to the species, the adaptability and fusion of traditional techniques in contemporary designs, the identification of the local’s people with the proposed models, as well as verification of sustainable guidelines applied in design and construction.
TEACHING AND APPLYING WATER CONSUMPTION SIMULTANEITY IN RESIDENTIAL: AN ACTIVE LEARNING PROJECT-BASED ENGINEERING APPROACH
Authors: Benavides Muñoz Holger Manuel , Granda Aguilar Luis Fernando , García Espinosa Juan Carlos
Published: March 2024

In the present project, spanning from April 2020 to August 2022, the study focused on Hydraulic Engineering I within the Civil Engineering program and the Hydrosanitary Installation Project in the Architecture program. The objectives included calculating the simultaneity coefficient and determining the maximum probable flow for each student's residence. To achieve these objectives, active learning methodologies, specifically project-based learning (PBL), were adeptly employed to enrich students' practical knowledge and foster collaboration. The process began with architectural surveys of residential properties, followed by inventories of pipes, sanitary appliances, and wet rooms. Measurements of flow rates at various faucet openings (25%, 50%, 75%, and 100%) were conducted, along with the recording of operating pressures within home networks. This data served as the foundation for creating calibration curves, a process carried out over 120 days. Using the collected data, each student developed a hydraulic model of their network and compared the software results to practical measurements. The participants calculated the simultaneity coefficient (Ks) and maximum possible flow for their dwellings using hydraulic design concepts and regulatory standards. The results were documented in technical reports, a video tutorial, and infographics. The research highlights the importance of understanding residential water usage patterns and their potential for optimizing water delivery systems. It also underscores the value of experiential learning, which helps students bridge theory and practice, enhancing technical skills and their understanding of hydraulic engineering.
WATER MANGEMENT IN SOCIAL HOUSING, STRETEGIES FOR SUSTAINABLE USE
Authors: Alvarado-Rodríguez Lorena Fernanda , Girón- Quizhpe Robin David , Aguirre-Maldonado Eduardo Bladimir , Valarezo-Jaramillo Sandra Vanessa , Balcázar-Arciniega Cristian André , Ordoñez-Salazar Santiago Vicente
Published: March 2024

Water is considered as a finite resource, in this context, studies suggest that by 2050, one in four people in the world will be affected by problems related to water service. In Ecuador, there is an alarming problem concerning the lack of awareness in the efficient use of water, since the daily consumption of liters per capita is 237 liters, which doubles the consumption recommended by the World Health Organization (WHO) and 40% higher than the regional average. The Sustainable Development Goals 6 and 11 aim to achieve universal and equitable access to water, sanitation and hygiene services by 2030. This research aims to propose sustainable strategies to optimize the use of water in single-family homes of social interest based on the results of the Ciudad Victoria, Loja-Ecuador housing complex. It was developed in four phases: climate data collection, satisfaction and demand surveys, housing characterization, data tabulation to propose strategies validated in water demand scenarios using CYPECAD MEP software. Data are obtained on the consumption of water used for household chores and 310-liter sanitary appliances, exceeding the 100-liter recommendation stated by the WHO. In this study, the data was alarming as households experience water supply interruptions throughout the year, and they lack reserve systems. Implemented strategies enabled a reduction in water consumption of between 30% and 50% per household.
AUTOMATION IN CONSTRUCTION: EDUCATION AND TRAINING FOR WORKFORCE DEVELOPMENT
Authors: Ilbeigi Mohammad , Chen Xi
Published: March 2024

The construction industry's 4th industrial revolution is transforming the nature of work for construction professionals and pushing them to gain new qualifications in terms of skills, knowledge, and abilities. Educational and training programs play a vital role in workforce development during this rapidly evolving transition. Although the construction research community has paid increasing attention to better understanding the emerging needs for education and training, there is still little knowledge about the design of novel educational and training approaches to overcome the unprecedented challenges during the automation era. The first step toward directing future research and investments in this domain is to systematically understand the scope of the present knowledge and identify the knowledge gaps that form the foundations for future research directions. This research fulfills this requirement by undertaking a scoping review utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Review (PRISMA-ScR) guidelines. The extracted information from the identified relevant studies was synthesized and mapped using a well-established framework. Using the outcomes of the systematic scoping review and its synthesis process, a series of knowledge gaps and potential directions for future research and scholarly works were identified and discussed.
Profit evolution for residential construction projects according to project characteristics
Authors: Guerra Miguel Andrés Andrés , Mosquera Ariel , Hidalgo Nicolás , Cevallos María , Mendez Valeria , Lara Michael
Published: March 2024

The following research paper analyzes the evolution of financial variables considered in residential real estate projects in Quito, Ecuador. The analysis depends on the general characteristics of each project, from 2006 until the present. Specifically, the analysis relates the profitability of a series of projects with their type, total size in square meters, and general costs of construction, among other factors. For this, 344 real estate business plans were studied to obtain general information of the construction, and later categorized according to financial variables established. Usually, the initial planning of construction projects is not fully accomplished, due to such factors as the owner, design, location, or financial reasons, among others. As demonstrated, the misuse of resources has caused delays in the construction process, leading to economic loss. Essentially, the financial planning must provide a detailed explanation of the behavior of the variables affecting the proposed project's viability and financial efficiency. These variables must achieve optimal and positive annual profitability for the project to be successful. The results obtained for general and annual profitability find that general characteristics, such as type and size, affected profitability by increasing chronologically. Additionally, it was found that general profitability was most beneficial for a specific type of building and house, regarding its size, which is an essential financial factor to consider when investing or carrying out the construction of any real estate project.