bluuebunny/crossref_metadata_2025 huggingface dataset:
Three-Dimensional Cephalometric Landmarking and Frankfort Horizontal Plane Construction: Reproducibility of Conventional and Novel Landmarks
Authors: Dot Gauthier , Rafflenbeul Frédéric , Kerbrat Adeline , Rouch Philippe , Gajny Laurent , Schouman Thomas
Published: November 2021

In some dentofacial deformity patients, especially patients undergoing surgical orthodontic treatments, Computed Tomography (CT) scans are useful to assess complex asymmetry or to plan orthognathic surgery. This assessment would be made easier for orthodontists and surgeons with a three-dimensional (3D) cephalometric analysis, which would require the localization of landmarks and the construction of reference planes. The objectives of this study were to assess manual landmarking repeatability and reproducibility (R&R) of a set of 3D landmarks and to evaluate R&R of vertical cephalometric measurements using two Frankfort Horizontal (FH) planes as references for horizontal 3D imaging reorientation. Thirty-three landmarks, divided into “conventional”, “foraminal” and “dental”, were manually located twice by three experienced operators on 20 randomly-selected CT scans of orthognathic surgery patients. R&R confidence intervals (CI) of each landmark in the -x, -y and -z directions were computed according to the ISO 5725 standard. These landmarks were then used to construct 2 FH planes: a conventional FH plane (orbitale left, porion right and left) and a newly proposed FH plane (midinternal acoustic foramen, orbitale right and left). R&R of vertical cephalometric measurements were computed using these 2 FH planes as horizontal references for CT reorientation. Landmarks showing a 95% CI of repeatability and/or reproducibility > 2 mm were found exclusively in the “conventional” landmarks group. Vertical measurements showed excellent R&R (95% CI < 1 mm) with either FH plane as horizontal reference. However, the 2 FH planes were not found to be parallel (absolute angular difference of 2.41°, SD 1.27°). Overall, “dental” and “foraminal” landmarks were more reliable than the “conventional” landmarks. Despite the poor reliability of the landmarks orbitale and porion, the construction of the conventional FH plane provided a reliable horizontal reference for 3D craniofacial CT scan reorientation.
Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes
Authors: Popiołek Alicja , Brzoszczyk Bartosz , Jarzemski Piotr , Chyrek-Tomaszewska Aleksandra , Wieczór Radosław , Borkowska Alina , Bieliński Maciej
Published: November 2021

Prostate cancer (PC) is one of the most common malignancies in men. The increase in the number of PC survivors is associated with many problems including cognitive impairment. Early detection of such problems facilitates timely protective intervention. This study examined the association between prostate-specific antigen (PSA) or testosterone (T) levels and cognitive function in patients undergoing radical prostatectomy. Such a correlation could help identify patient groups at risk of cognitive impairment. Participants underwent clinical (demographic data, medical history, physical examination, and blood analyses) and neuropsychological assessment (cognitive test battery). Preoperative PSA or T levels were not associated with cognitive function. However, long-term follow-up after prostatectomy showed a strong correlation between PSA levels and the results of verbal memory and executive function tests. A trend toward significance was also observed for visuospatial memory. The levels of free T and total T were not correlated with cognitive function. Only the levels of free T after hormonal treatment were significantly correlated with executive functions. Comorbid diabetes affected these correlations. In conclusion, PSA levels at a distant postoperative time and free T level after hormonal treatment may be biomarkers of cognitive function.
Is Chronic Kidney Disease Affecting the Postoperative Complications of Vitrectomy for Proliferative Diabetic Retinopathy?
Authors: Kameda Yusuke , Saeki Tadashiro , Hanai Ko , Suzuki Yuta , Uchigata Yasuko , Babazono Tetsuya , Kitano Shigehiko
Published: November 2021

Chronic kidney disease (CKD) is a well-known risk factor for postoperative complications in several surgical fields. However, although prevalent among diabetic candidates for vitrectomy, the effect of CKD on vitrectomy outcomes remains unclear. This study aimed at clarifying the relationship between CKD and the occurrence of vitrectomy-related complications in patients with proliferative diabetic retinopathy (PDR). The 6-month incidences of vitreous hemorrhage (VH) and neovascular glaucoma (NVG) following vitrectomy for PDR were compared among the following groups: stages 1–2 CKD (60 patients), stages 3–5 CKD (70 patients not on hemodialysis), and hemodialysis (HD; 30 patients). We also determined whether the deterioration of the estimated glomerular filtration rate (eGFR) was associated with post-vitrectomy events. The incidence of VH was significantly higher in the stages 3–5 CKD group (43%) than in the stages 1–2 CKD (10%) and HD (10%) groups. NVG was more common in the stages 3–5 CKD group (17%) than in the stages 1–2 CKD (2%) and HD (0%) groups. The reduced estimated glomerular filtration rate (eGFR) was the only significant variable associated with post-vitrectomy VH and NVG. Patients with PDR and CKD, particularly those with lower eGFR, might be at risk for post-vitrectomy VH and NVG.
An Improved Dueling Deep Double-Q Network Based on Prioritized Experience Replay for Path Planning of Unmanned Surface Vehicles
Authors: Zhu Zhengwei , Hu Can , Zhu Chenyang , Zhu Yanping , Sheng Yu
Published: November 2021

Unmanned Surface Vehicle (USV) has a broad application prospect and autonomous path planning as its crucial technology has developed into a hot research direction in the field of USV research. This paper proposes an Improved Dueling Deep Double-Q Network Based on Prioritized Experience Replay (IPD3QN) to address the slow and unstable convergence of traditional Deep Q Network (DQN) algorithms in autonomous path planning of USV. Firstly, we use the deep double Q-Network to decouple the selection and calculation of the target Q value action to eliminate overestimation. The prioritized experience replay method is adopted to extract experience samples from the experience replay unit, increase the utilization rate of actual samples, and accelerate the training speed of the neural network. Then, the neural network is optimized by introducing a dueling network structure. Finally, the soft update method is used to improve the stability of the algorithm, and the dynamic ϵ-greedy method is used to find the optimal strategy. The experiments are first conducted in the Open AI Gym test platform to pre-validate the algorithm for two classical control problems: the Cart pole and Mountain Car problems. The impact of algorithm hyperparameters on the model performance is analyzed in detail. The algorithm is then validated in the Maze environment. The comparative analysis of simulation experiments shows that IPD3QN has a significant improvement in learning performance regarding convergence speed and convergence stability compared with DQN, D3QN, PD2QN, PDQN, PD3QN. Also, USV can plan the optimal path according to the actual navigation environment with the IPD3QN algorithm.
Propulsion Performance and Wake Dynamics of Heaving Foils under Different Waveform Input Perturbations
Authors: Gao Pengcheng , Huang Qiaogao , Pan Guang
Published: November 2021

A numerical simulation is used to investigate the effects of adding high frequency and low amplitude perturbations of different waveforms to the sinusoidal-based signal of the heaving foil on the propulsion performance and wake structure. We use the adjustable parameter k to achieve a heaving motion of various waveform cycle trajectories, such as sawtooth, sine, and square. Adding a perturbation of whatever waveform is beneficial in increasing the thrust of the heaving foil, especially by adding a square wave perturbation with a frequency of 10 Hz, pushes the thrust up to 10.49 times that without the perturbation. However, the addition of the perturbation signal brings a reduction in propulsion efficiency, and the larger the perturbation frequency, the lower the efficiency. The wake structure of the heaving foil behaves similarly under different waveform perturbations, all going through some intermediate stages, which eventually evolve into a chaotic wake with the increase in the perturbation frequency. However, a lower frequency square wave perturbation can destabilize the heaving foil wake structure. This work further explains the effect of different waveform perturbation signals on the base sinusoidal signal and provides a new control idea for underwater vehicles.
Taiwan Expert Consensus Recommendations for Switching to Aripiprazole Long-Acting Once-Monthly in Patients with Schizophrenia
Authors: Liang Chih-Sung , Su Tung-Ping , Hsieh Ming-Hsien , Lee Chau-Shoun , Kuo Joseph , Chiu Nan-Ying , Chen Po-See , Yen Yung-Chieh , Bai Ya-Mei
Published: November 2021

In the last decade, long-acting injectable antipsychotics has been widely used in schizophrenia. Aripiprazole long-acting once-monthly (AOM) is the only long-acting dopamine partial agonist antipsychotic approved for schizophrenia; however, a literature search revealed no guidance on safely switching from oral and long-acting injectable antipsychotics to AOM. This study aimed to develop recommendations of AOM use based on existing data and expert consensus. A committee of 30 experts in psychopharmacology from major hospitals across Taiwan was invited. A modified Delphi method was conducted, consisting of two rounds of questionnaires, literature review, three rounds of face-to-face discussion meeting, and two rounds of anonymous voting. The consensus recommendations were developed based on existing data, clinical experiences, and consensus opinions, with 80% agreement among panel members required for final adoption. The panel developed nine consensus statements of switching to AOM for both acute and stable schizophrenia patients receiving oral or long-acting injectable atypical antipsychotics. Recommendations regarding dose adjustment of oral medication and pregnancy/breastfeeding were also included. The nine consensus recommendations provide a guidance on safely switching to AOM. Substantial gaps in knowledge, and more research is necessary.
Innate-Immunity Genes in Obesity
Authors: Mikhailova Svetlana V. , Ivanoshchuk Dinara E.
Published: November 2021

The main functions of adipose tissue are thought to be storage and mobilization of the body’s energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discovery of adipokines, the endocrine function was added to the above list, and after the identification of crosstalk between adipocytes and immune cells, an immune function was suggested. Nonetheless, it turned out that the mechanisms underlying mutual regulatory relations of adipocytes, preadipocytes, immune cells, and their microenvironment are complex and redundant at many levels. One possible way to elucidate the picture of adipose-tissue regulation is to determine genetic variants correlating with obesity. In this review, we examine various aspects of adipose-tissue involvement in innate immune responses as well as variants of immune-response genes associated with obesity.
An Assessment of Post-COVID-19 EU Recovery Funds and the Distribution of Them among Member States
Authors: Guillamón María-Dolores , Ríos Ana-María , Benito Bernardino
Published: November 2021

The European Commission has launched numerous recovery plans for Member States to try to mitigate the damage caused by COVID-19. The most important element of this program is the Recovery and Resilience Facility (RRF), which is worth EUR 672.5 billion in loans and grants. Seventy per cent of the RRF grants will be distributed between 2021 and 2022, with the remaining 30 per cent in 2023. The allocation of grants for the period 2021–2022 has been made according to different socioeconomic criteria. In this context, the aim of our work is to assess the recovery policies jointly developed by EU countries and to analyze which of the criteria adopted for the allocation of the grants included in the RRF for the period 2021–2022 has been most decisive in the distribution of these funds. In addition, we also examine whether other health indicators directly related to the pandemic can also be related to the amount of funding that EU countries will receive in this period by carrying out regression analysis. Our results show that the countries that will receive more RRF grants are those with larger populations, Gross Domestic Product (GDP) per capita and higher unemployment rates. Furthermore, it is noted that health criteria, as well as those of a socioeconomic nature, may be relevant in the allocation of recovery funds. In this way, our results can be the start of a debate in the literature on whether the socioeconomic criteria adopted in the distribution of these funds have been appropriate. or whether other criteria, such as those of a health nature, should have been taken into account.
How Many Stocks Are Sufficient for Equity Portfolio Diversification? A Review of the Literature
Authors: Zaimovic Azra , Omanovic Adna , Arnaut-Berilo Almira
Published: November 2021

Using extensive and comprehensive databases to select a subset of research papers, we aim to critically analyze previous empirical studies to identify certain patterns in determining the optimal number of stocks in well-diversified portfolios in different markets, and to compare how the optimal number of stocks has changed over different periods and how it has been affected by market turmoil such as the Global Financial Crisis (GFC) and the current COVID-19 pandemic. The main methods used are bibliometric analysis and systematic literature review. Evaluating the number of assets which lead to optimal diversification is not an easy task as it is impacted by a huge number of different factors: the way systematic risk is measured, the investment universe (size, asset classes and features of the asset classes), the investor’s characteristics, the change over time of the asset features, the model adopted to measure diversification (i.e., equally weighted versus optimal allocation), the frequency of the data that is being used, together with the time horizon, conditions in the market that the study refers to, etc. Our paper provides additional support for the fact that (1) a generalized optimal number of stocks that constitute a well-diversified portfolio does not exist for whichever market, period or investor. Recent studies further suggest that (2) the size of a well-diversified portfolio is larger today than in the past, (3) this number is lower in emerging markets compared to developed financial markets, (4) the higher the stock correlations with the market, the lower the number of stocks required for a well-diversified portfolio for individual investors, and (5) machine learning methods could potentially improve the investment decision process. Our results could be helpful to private and institutional investors in constructing and managing their portfolios and provide a framework for future research.
Effects of In Vitro Muscle Contraction on Thermogenic Protein Levels in Co-Cultured Adipocytes
Authors: Nintou Eleni , Karligiotou Eleni , Vliora Maria , Fatouros Ioannis G. , Jamurtas Athanasios Z. , Sakellaridis Nikos , Dimas Konstantinos , Flouris Andreas D.
Published: November 2021

The crosstalk between the exercising muscle and the adipose tissue, mediated by myokines and metabolites, derived from both tissues during exercise has created a controversy between animal and human studies with respect to the impact of exercise on the browning process. The aim of this study was to investigate whether co-culturing of C2C12 myotubes and 3T3-L1 adipocytes under the stimuli of electrical pulse stimulation (EPS) mimicking muscle contraction can impact the expression of UCP1, PGC-1a, and IL-6 in adipocytes, therefore providing evidence on the direct crosstalk between adipocytes and stimulated muscle cells. In the co-cultured C2C12 cells, EPS increased the expression of PGC-1a (p = 0.129; d = 0.73) and IL-6 (p = 0.09; d = 1.13) protein levels. When EPS was applied, we found that co-culturing led to increases in UCP1 (p = 0.044; d = 1.29) and IL-6 (p = 0.097; d = 1.13) protein expression in the 3T3-L1 adipocytes. The expression of PGC-1a increased by EPS but was not significantly elevated after co-culturing (p = 0.448; d = 0.08). In vitro co-culturing of C2C12 myotubes and 3T3-L1 adipocytes under the stimuli of EPS leads to increased expression of thermogenic proteins. These findings indicate changes in the expression pattern of proteins related to browning of adipose tissue, supporting the use of this in vitro model to study the crosstalk between adipocytes and contracting muscle.
An Insight into Vaginal Microbiome Techniques
Authors: Sharma Mahima , Chopra Chitrakshi , Mehta Malvika , Sharma Varun , Mallubhotla Sharada , Sistla Srinivas , Sistla Jyothi C. , Bhushan Indu
Published: November 2021

There is a unique microbial community in the female lower genital tract known as the vaginal microbiota, which varies in composition and density and provides significant benefits during pregnancy, reproductive cyclicity, healthy newborn delivery, protection from preterm birth, infections such as UTIs, bacterial vaginosis, and so on, and improves the efficacy of treatments for vaginal cancers. Methods: It is necessary to know how the vaginal microbiome is composed in order to make an accurate diagnosis of the diseases listed above. A microbiome’s members are difficult to classify, and the way microbial communities function and influence host–pathogen interactions are difficult to understand. More and more metagenomic studies are able to unravel such complexities due to advances in high-throughput sequencing and bioinformatics. When it comes to vaginal microbiota research, we’ll be looking at the use of modern techniques and strategies that can be used to investigate variations in vaginal microbiota in order to detect diseases earlier, better treat vaginal disorders, and boost women’s health. Discussion: The discussed techniques and strategies may improve the treatment of vaginal disorders and may be beneficial for women’s overall health.
Whole Exome Sequencing Identifies a Novel Homozygous Missense Mutation in the CSB Protein-Encoding ERCC6 Gene in a Taiwanese Boy with Cockayne Syndrome
Authors: Lin Ching-Ming , Yang Jay-How , Lee Hwei-Jen , Lin Yu-Pang , Tsai Li-Ping , Hsu Chih-Sin , Luxton G. W. Gant , Hu Chih-Fen
Published: November 2021

Background: Cockayne syndrome (CS) is a rare form of dwarfism that is characterized by progressive premature aging. CS is typically caused by mutations in the excision repair cross-complementing protein group 6 (ERCC6) gene that encodes the CS group B (CSB) protein. Using whole exome sequencing, we recently identified a novel homozygous missense mutation (Leu536Trp) in CSB in a Taiwanese boy with CS. Since the current database (Varsome) interprets this variant as likely pathogenic, we utilized a bioinformatic tool to investigate the impact of Leu536Trp as well as two other variants (Arg453Ter, Asp532Gly) in similar articles on the CSB protein structure stability. Methods: We used iterative threading assembly refinement (I-TASSER) to generate a predictive 3D structure of CSB. We calculated the change of mutation energy after residues substitution on the protein stability using I-TASSER as well as the artificial intelligence program Alphafold. Results: The Asp532Gly variant destabilized both modeled structures, while the Leu536Trp variant showed no effect on I-TASSER’s model but destabilized the Alphafold’s modeled structure. Conclusions: We propose here the first case of CS associated with a novel homozygous missense mutation (Leu536Trp) in CSB. Furthermore, we suggest that the Asp532Gly and Leu536Trp variants are both pathogenic after bioinformatic analysis of protein stability.
Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression in Drosophila
Authors: Duk Maria A. , Gursky Vitaly V. , Samsonova Maria G. , Surkova Svetlana Yu.
Published: November 2021

Unlike transcriptional regulation, the post-transcriptional mechanisms underlying zygotic segmentation gene expression in early Drosophila embryo have been insufficiently investigated. Condition-specific post-transcriptional regulation plays an important role in the development of many organisms. Our recent study revealed the domain- and genotype-specific differences between mRNA and the protein expression of Drosophila hb, gt, and eve genes in cleavage cycle 14A. Here, we use this dataset and the dynamic mathematical model to recapitulate protein expression from the corresponding mRNA patterns. The condition-specific nonuniformity in parameter values is further interpreted in terms of possible post-transcriptional modifications. For hb expression in wild-type embryos, our results predict the position-specific differences in protein production. The protein synthesis rate parameter is significantly higher in hb anterior domain compared to the posterior domain. The parameter sets describing Gt protein dynamics in wild-type embryos and Kr mutants are genotype-specific. The spatial discrepancy between gt mRNA and protein posterior expression in Kr mutants is well reproduced by the whole axis model, thus rejecting the involvement of post-transcriptional mechanisms. Our models fail to describe the full dynamics of eve expression, presumably due to its complex shape and the variable time delays between mRNA and protein patterns, which likely require a more complex model. Overall, our modeling approach enables the prediction of regulatory scenarios underlying the condition-specific differences between mRNA and protein expression in early embryo.
Comparative Genomics Analysis of Repetitive Elements in Ten Gymnosperm Species: “Dark Repeatome” and Its Abundance in Conifer and Gnetum Species
Authors: Titievsky Avi , Putintseva Yuliya A. , Taranenko Elizaveta A. , Baskin Sofya , Oreshkova Natalia V. , Brodsky Elia , Sharova Alexandra V. , Sharov Vadim V. , Panov Julia , Kuzmin Dmitry A. , Brodsky Leonid , Krutovsky Konstantin V.
Published: November 2021

Repetitive elements (RE) and transposons (TE) can comprise up to 80% of some plant genomes and may be essential for regulating their evolution and adaptation. The “repeatome” information is often unavailable in assembled genomes because genomic areas of repeats are challenging to assemble and are often missing from final assembly. However, raw genomic sequencing data contain rich information about RE/TEs. Here, raw genomic NGS reads of 10 gymnosperm species were studied for the content and abundance patterns of their “repeatome”. We utilized a combination of alignment on databases of repetitive elements and de novo assembly of highly repetitive sequences from genomic sequencing reads to characterize and calculate the abundance of known and putative repetitive elements in the genomes of 10 conifer plants: Pinus taeda, Pinus sylvestris, Pinus sibirica, Picea glauca, Picea abies, Abies sibirica, Larix sibirica, Juniperus communis, Taxus baccata, and Gnetum gnemon. We found that genome abundances of known and newly discovered putative repeats are specific to phylogenetically close groups of species and match biological taxa. The grouping of species based on abundances of known repeats closely matches the grouping based on abundances of newly discovered putative repeats (kChains) and matches the known taxonomic relations.
Alternating Positive and Negative Feedback Control Model Based on Catastrophe Theories
Authors: Huang Wenkai , Zhou Fobao , Zou Tao , Lu Puwei , Xue Yihao , Liang Jiajian , Dong Yikai
Published: November 2021

In automatic control systems, negative feedback control has the advantage of maintaining a steady state, while positive feedback control can enhance some activities of the control system. How to design a controller with both control modes is an interesting and challenging problem. Motivated by it, on the basis idea of catastrophe theories, taking positive feedback and negative feedback as two different states of the system, an adaptive alternating positive and negative feedback (APNF) control model with the advantages of two states is proposed. By adaptively adjusting the relevant parameters of the constructed symmetric catastrophe function and the learning rule based on error and forward weight, the two states can be switched in the form of catastrophe. Through the Lyapunov stability theory, the convergence of the proposed adaptive APNF control model is proven, which indicates that system convergence can be guaranteed by selecting appropriate parameters. Moreover, we present theoretical proof that the negative feedback system with negative parameters can be equivalent to the positive feedback system with positive parameters. Finally, the results of the simulation example show that APNF control has satisfactory performance in response speed and overshoot.
Robust Model Predictive Control Paradigm for Automatic Voltage Regulators against Uncertainty Based on Optimization Algorithms
Authors: Elsisi Mahmoud , Tran Minh-Quang , Hasanien Hany M. , Turky Rania A. , Albalawi Fahad , Ghoneim Sherif S. M.
Published: November 2021

This paper introduces a robust model predictive controller (MPC) to operate an automatic voltage regulator (AVR). The design strategy tends to handle the uncertainty issue of the AVR parameters. Frequency domain conditions are derived from the Hermite–Biehler theorem to maintain the stability of the perturbed system. The tuning of the MPC parameters is performed based on a new evolutionary algorithm named arithmetic optimization algorithm (AOA), while the expert designers use trial and error methods to achieve this target. The stability constraints are handled during the tuning process. An effective time-domain objective is formulated to guarantee good performance for the AVR by minimizing the voltage maximum overshoot and the response settling time simultaneously. The results of the suggested AOA-based robust MPC are compared with various techniques in the literature. The system response demonstrates the effectiveness and robustness of the proposed strategy with low control effort against the voltage variations and the parameters’ uncertainty compared with other techniques.
On Johnson’s “Sufficientness” Postulates for Feature-Sampling Models
Authors: Camerlenghi Federico , Favaro Stefano
Published: November 2021

In the 1920s, the English philosopher W.E. Johnson introduced a characterization of the symmetric Dirichlet prior distribution in terms of its predictive distribution. This is typically referred to as Johnson’s “sufficientness” postulate, and it has been the subject of many contributions in Bayesian statistics, leading to predictive characterization for infinite-dimensional generalizations of the Dirichlet distribution, i.e., species-sampling models. In this paper, we review “sufficientness” postulates for species-sampling models, and then investigate analogous predictive characterizations for the more general feature-sampling models. In particular, we present a “sufficientness” postulate for a class of feature-sampling models referred to as Scaled Processes (SPs), and then discuss analogous characterizations in the general setup of feature-sampling models.
Approximate Noether Symmetries of Perturbed Lagrangians and Approximate Conservation Laws
Authors: Gorgone Matteo , Oliveri Francesco
Published: November 2021

In this paper, within the framework of the consistent approach recently introduced for approximate Lie symmetries of differential equations, we consider approximate Noether symmetries of variational problems involving small terms. Then, we state an approximate Noether theorem leading to the construction of approximate conservation laws. Some illustrative applications are presented.
Thermo-Optical Mechanical Waves in a Rotating Solid Semiconductor Sphere Using the Improved Green–Naghdi III Model
Authors: Abouelregal Ahmed E. , Marin Marin , Askar Sameh
Published: November 2021

The current study investigates thermophotovoltaic interactions using a new mathematical model of thermoelasticity established on a modification of the Green–Naghdi model of type III (GN-III). The basic equations, in which the heat transfer is in the form of the Moore–Gibson–Thompson (MGT) equation, are derived by adding a single delay factor to the GN-III model. The impact of temperature and electrical elastic displacement of semiconductors throughout the excited thermoelectric mechanism can be studied theoretically using this model. The proposed model was used to investigate the interactions between the processes of thermoelastic plasma in a rotating semiconductor solid sphere that was subjected to a thermal shock and crossed to an externally applied magnetic field. The influence of rotation parameters on various photothermal characteristics of silicon solid was presented and explored using the Laplace technique.
PDE Surface-Represented Facial Blendshapes
Authors: Fu Haibin , Bian Shaojun , Chaudhry Ehtzaz , Wang Shuangbu , You Lihua , Zhang Jian Jun
Published: November 2021

Partial differential equation (PDE)-based geometric modelling and computer animation has been extensively investigated in the last three decades. However, the PDE surface-represented facial blendshapes have not been investigated. In this paper, we propose a new method of facial blendshapes by using curve-defined and Fourier series-represented PDE surfaces. In order to develop this new method, first, we design a curve template and use it to extract curves from polygon facial models. Then, we propose a second-order partial differential equation and combine it with the constraints of the extracted curves as boundary curves to develop a mathematical model of curve-defined PDE surfaces. After that, we introduce a generalized Fourier series representation to solve the second-order partial differential equation subjected to the constraints of the extracted boundary curves and obtain an analytical mathematical expression of curve-defined and Fourier series-represented PDE surfaces. The mathematical expression is used to develop a new PDE surface-based interpolation method of creating new facial models from one source facial model and one target facial model and a new PDE surface-based blending method of creating more new facial models from one source facial model and many target facial models. Some examples are presented to demonstrate the effectiveness and applications of the proposed method in 3D facial blendshapes.
Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions
Authors: Chuang Hao-Wen , Wang Jyh-Seng , Tsai Jen-Wei , Hsu Chao-Tien , Lin Kai-Jen
Published: November 2021

Background and Objectives: We aimed to assess the diagnostic value of various immunohistochemical (IHC) markers and panels for differentiation among benign follicular nodules (BFNs), noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs), noninvasive encapsulated follicular variants of papillary thyroid carcinoma (NEFVPTCs), and infiltrative FVPTC (IFVPTC). Materials and Methods: Sixty-three cases were classified as BFNs, NIFTPs, NEFVPTCs, or IFVPTCs and were evaluated using the following markers: CK19, CD56, galectin-3, CITED1, HBME-1, VE1, and TROP-2. Results: The IHC results for NIFTP and NEFVPTC exhibited no statistically significant differences. In differentiating IFVPTCs from BFNs and NIFTPs/NEFVPTCs, galectin-3 and TROP-2 were the markers with the highest sensitivity plus high specificity, respectively. In various combinations, panel co-expression of two markers, including galectin-3 and/or HBME-1 and/or TROP-2, and the combination of galectin-3 and TROP-2 co-expression could achieve 100% in all aspects. In terms of discrimination of BFNs from NIFTP/NEFVPTC, CK19 was the single most sensitive marker (81.3%), while CD56 was the most specific (100%). The panel consisting of CK19 and/or HBME-1 exhibited the greatest sensitivity (96.9%), but the panel with CD56 and/or HBME-1 exhibited the greatest specificity (90.5%). Conclusions: Our results broaden the use of IHC markers for differential diagnoses among the four groups of follicular-based lesions. In addition, the similar IHC profiles of NIFTP and NEFVPTC also suggest the original criterion of <1% papillae within tumors, providing a reliable NIFTP diagnosis. Their close relationship may represent a spectrum of progressing neoplasia.
Clinical Outcome of Primary Total Hip Arthroplasty in Patients with Morbid Obesity—Retrospective and Prospective Follow-Up Studies
Authors: Gritsyuk Andrey , Lychagin Alexey , Yi Liu , Rosenberg Nahum
Published: November 2021

Background and objective: There is a general clinical concern on the negative impact of obesity on surgical complications and functional outcomes. We hypothesized that the patients with morbid obesity are exceptionally prone to a significantly increased risk for surgical and short-term complications after primary total hip arthroplasty (THA). We aimed to identify the range of Body Mass Index (BMI) values of patients with a significant risk for lower functional improvement after THA. Materials and methods: In Stage 1 of the study, we conducted a retrospective comparative analysis of the rate of complications and functional outcomes in patients treated by primary THA, with normal weight (BMI 19–25, N = 1205) vs. Class 1 (BMI 26–34, N = 450), Class 2 (BMI 35–39, N = 183), and Class 3 (BMI ≥ 40, N = 47) obese patients. After the statistical similarity rates of complications and 6- and 12-month functional outcomes (by Harris Hip and SF-36 scores) were revealed in Class 1 patients and patients with normal BMI, we conducted the Stage 2 prospective study, by the same comparison protocol, on the cohorts of Class 2 (N = 29) and Class 3 (N = 16) patients compared to the Class 1 patients (N = 37) as controls. Results: Stage 1: There was no difference in surgical complications and function on 6- and 12-month postoperative follow-up (physical and mental) between Class 1 and patients with normal BMI (p > 0.05). Surgical complications were significantly higher in Class 2 (p < 0.05) and Class 3 (p < 0.001) patients. Functional activity on the 12-month follow-up increased significantly in all study groups, but in the Class 3 patients, the functional parameters were significantly lower (0.001). The mental health status on the follow-up was similar in all study groups. Stage 2 study revealed similar to the retrospective study comparison of parameters, except for the significantly lower mental health scores in Class 2 and Class 3 patients (p < 0.05) and functional scores in Class 3 patients (p < 0.05). Conclusion: Although the functional ability increased in all patients, it was significantly lower in Class 3 patients (with morbid obesity). Therefore, the patients with Class 1 and Class 2 obesity should be conceptionally distinguished from Class 3 patients in the decision-making process for a primary THA because of the less favorable functional and mental health improvement in those with morbid obesity (Class 3).
Membrane Surface Modification and Functionalization
Authors: Vasagar Vivek , Hassan Mohammad K. , Khraisheh Majeda
Published: November 2021

With the increase in water scarcity, and as only 2 [...]
Ab Initio Molecular Dynamics Study of the Structure and Properties of Nb-Doped Zr-Cu-Al Amorphous Alloys
Authors: Wei Hongqing , Zhang Ping , Tang Yi
Published: November 2021

In this paper, experiments were carried out on (Zr0.5Cu0.4Al0.1)100-xNbx (x = 0, 3, 6 at.%) amorphous alloys, and the corresponding ab initio molecular dynamics simulation was performed. The results showed that stable structures of Nb-centered and Al-centered icosahedral (-like) atomic clusters were formed after a small amount of (3 at.%) Nb was added. Stable and close-packed backbone structures were formed by the means of interconnection and matching of the two kinds of stable clusters in the alloys, which also enhanced the overall heterogeneity of the structures, thereby improving the strength and macroscopic plasticity. In addition, when more (6 at.%) Nb was added, the stable Al-centered clusters were replaced by some stable Nb-centered clusters in the alloys, and the stability and heterogeneity of the structures were partly reduced, which reduced the strength and macroscopic plasticity.
Effect of Electromagnetic Frequency on the Flow Behavior in Mold during Bloom Casting
Authors: Li Xianglong , Hu Shaoyan , Wang Deyong , Qu Tianpeng , Quan Qi , Zhou Xingzhi
Published: November 2021

Considering solidification, a large eddy simulation (LES) model of two-phase flow was established to simulate the thermal–magnetic flow coupled fields inside a jumbo bloom. The magnetic field was calculated based on Maxwell’s equations, constitutive equations, and Ohm’s law. An enthalpy–porosity technique was used to model the solidification of the steel. The movement of the free surface was described by the volume of fluid (VOF) approach. With the effect of electromagnetic stirring (MEMS), the vortices in the bloom tended to be strip-like; large vortices mostly appeared in the injection zone, while small ones were found near the surface of the bloom. It is newly found that even though the submerged entry nozzle (SEN) is asymmetrical about the bloom, a biased flow can also be found under the effect of MEMS. The reason for this phenomenon is because the magnetic force is asymmetrical and transient. A high frequency will reduce the period of biased flow; however, the frequency should not be too high because it could also intensify meniscus fluctuations and thus entrap slag droplets in the mold. The velocity near the solidification front can also be increased with a higher frequency.
Coated Metal Powders for Laser Powder Bed Fusion (L-PBF) Processing: A Review
Authors: Bidulsky Robert , Gobber Federico Simone , Bidulska Jana , Ceroni Marta , Kvackaj Tibor , Grande Marco Actis
Published: November 2021

In the last years, functionalized powders are becoming of increasing interest in additive manufacturing (particularly in laser powder bed fusion processing, L-PBF), due to their improved flowability and enhanced processability, particularly in terms of laser absorbance. Functionalized powders may also provide higher final mechanical or physical properties in the manufactured parts, like an increased hardness, a higher tensile strength, and density levels close to theoretical. Coatings represent a possible interesting approach for powders’ functionalizing. Different coating methods have been studied in the past years, either mechanical or non-mechanical. This work aims to present an overview of the currently obtained coated powders, analyzing in detail the processes adopted for their production, the processability of the coated systems, and the mechanical and physical properties of the final parts obtained by using L-PBF for the powders processing.
Demulsification Behavior of Alkali and Organic Acid in Zinc Extraction
Authors: Jiang Tao , Meng Feiyu , Li Ke , Zhong Qaing , Xu Bin , Li Qian , Yang Yongbin
Published: November 2021

Alkali agents could be used to enhance the extraction of zinc from solution of high concentration, but excess alkali can sensitively lead to emulsification of the solution. In this paper, the emulsification in the extraction process, demulsification, and extraction with different additives and its action mechanism were studied. The results indicate that the associated addition of alkali and organic acid could eliminate emulsification and improve zinc extraction. The extraction ratio of zinc reached 99.61% under the conditions of 104 mL/L organic acid, 80 g/L alkali, and 40% extractant concentration. Zinc hydroxide formed from hydroxyl and zinc ion at sensitively increased pH was the cause of emulsification during extraction. Associated addition of alkali and organic acid could contribute to the control solution pH in the range of 3.0–4.0, which is lower than that of the formation of zinc hydroxide, and therefore, improve zinc extraction.
l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
Authors: Matsuoka Kanako , Akaihata Hidenori , Hata Junya , Tanji Ryo , Honda-Takinami Ruriko , Onagi Akifumi , Hoshi Seiji , Koguchi Tomoyuki , Sato Yuichi , Kataoka Masao , Ogawa Soichiro , Kojima Yoshiyuki
Published: November 2021

Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether l-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary component for daily consumption. Spontaneously hypertensive rats (SHRs), as an animal model of bladder dysfunction, were divided into SHR–water and SHR–theanine groups. After 6 weeks of oral administration, the sympathetic nervous system, bladder function, and oxidative stress of bladder tissue were evaluated. The mean blood pressure, serum noradrenaline level, and media-to-lumen ratio of small arteries in the suburothelium were significantly lower in the SHR–theanine than in the SHR–water group. Micturition interval was significantly longer, and bladder capacity was significantly higher in the SHR–theanine than in the SHR–water group. Bladder strip contractility was also higher in the SHR–theanine than in the SHR–water group. Western blotting of bladder showed that expression of malondialdehyde was significantly lower in the SHR–theanine than in the SHR–water group. These results suggested that orally administered l-theanine may contribute at least partly to the prevention of bladder dysfunctions by inhibiting chronic sympathetic hyperactivity and protecting bladder contractility.
Polycarbonate Masters for Soft Lithography
Authors: Amadeo Filippo , Mukherjee Prithviraj , Gao Hua , Zhou Jian , Papautsky Ian
Published: November 2021

Fabrication of microfluidic devices by soft lithography is by far the most popular approach due to its simplicity and low cost. The approach relies on casting of elastomers, such as polydimethylsiloxane (PDMS), on masters fabricated from photoresists on silicon substrates. These masters, however, can be expensive, complicated to fabricate, and fragile. Here we describe an optimized replica molding approach to preserve the original masters by heat molding of polycarbonate (PC) sheets on PDMS molds. The process is faster and simpler than previously reported methods and does not result in a loss of resolution or aspect ratio for the features. The generated PC masters were used to successfully replicate a wide range of microfluidic devices, including rectangular channels with aspect ratios from 0.025 to 7.3, large area spiral channels, and micropost arrays with 5 µm spacing. Moreover, fabrication of rounded features, such as semi-spherical microwells, was possible and easy. Quantitative analysis of the replicated features showed variability of <2%. The approach is low cost, does not require cleanroom setting or hazardous chemicals, and is rapid and simple. The fabricated masters are rigid and survive numerous replication cycles. Moreover, damaged or missing masters can be easily replaced by reproduction from previously cast PDMS replicas. All of these advantages make the PC masters highly desirable for long-term preservation of soft lithography masters for microfluidic devices.
Thermal Analysis of 3D Electromagnetic Radiative Nanofluid Flow with Suction/Blowing: Darcy–Forchheimer Scheme
Authors: Alotaibi Hammad , Eid Mohamed R.
Published: November 2021

This paper discusses the Darcy–Forchheimer three dimensional (3D) flow of a permeable nanofluid through a convectively heated porous extending surface under the influences of the magnetic field and nonlinear radiation. The higher-order chemical reactions with activation energy and heat source (sink) impacts are considered. We integrate the nanofluid model by using Brownian diffusion and thermophoresis. To convert PDEs (partial differential equations) into non-linear ODEs (ordinary differential equations), an effective, self-similar transformation is used. With the fourth–fifth order Runge–Kutta–Fehlberg (RKF45) approach using the shooting technique, the consequent differential system set is numerically solved. The influence of dimensionless parameters on velocity, temperature, and nanoparticle volume fraction profiles is revealed via graphs. Results of nanofluid flow and heat as well as the convective heat transport coefficient, drag force coefficient, and Nusselt and Sherwood numbers under the impact of the studied parameters are discussed and presented through graphs and tables. Numerical simulations show that the increment in activation energy and the order of the chemical reaction boosts the concentration, and the reverse happens with thermal radiation. Applications of such attractive nanofluids include plastic and rubber sheet production, oil production, metalworking processes such as hot rolling, water in reservoirs, melt spinning as a metal forming technique, elastic polymer substances, heat exchangers, emollient production, paints, catalytic reactors, and glass fiber production.
Biodiversity of Soil Bacterial Communities from the Sasso Fratino Integral Nature Reserve
Authors: Castronovo Lara Mitia , Del Duca Sara , Chioccioli Sofia , Vassallo Alberto , Fibbi Donatella , Coppini Ester , Chioccioli Piero , Santini Giacomo , Zaccaroni Marco , Fani Renato
Published: November 2021

The Sasso Fratino Integral Nature Reserve (Italy) aims to protect nature and territory. Since no anthropic activities are allowed, it represents a good model to study the bacterial community of a wild environment. The aim of this work was to characterise the cultivable and the total bacterial community of soil samples from the reserve in terms of taxonomy, composition, and structure. Seven soil samples were collected at different altitudes, and the chemical composition, the total and the cultivable microbiota, and the antibiotic resistance profiles of isolates were investigated. Total bacterial communities, studied through Next Generation Sequences analysis, included 390 genera. Samples differed in terms of microbial composition basing on the different altitude/vegetation of collection points. Random Amplified Polymorphic DNA Analysis (RAPD) allowed to identify 82 haplotypes out of 158 bacterial isolates. The taxonomic identification through 16S rDNA sequencing revealed that the strains were affiliated to 21 genera. Antibiotic resistance profiles of bacteria were also investigated, highlighting a high resistance against streptomycin and kanamycin. This work represents the first description of the soil bacterial community from the Natural Reserve of Sasso Fratino, and it is the first study considering the soil microbiota of an Italian integral nature reserve.