bluuebunny/crossref_metadata_2025 huggingface dataset:
Redes de maestras y sabedores: diálogos ambientales de frontera, en la relación ciudad-región, y sus prácticas culturales-comunicativas
Authors: Castiblanco Roldán Andrés , Cuineme Rodríguez Mónica
Published: January 2021

Se exponen algunas reflexiones producto de los resultados del proyecto “Kiva Pedagógica”, surgido de la participación de maestros de las redes Chisua (colectivo de educadores colombianos) y Red de Comunicación Popular (colectivo de maestros, sabedores y sabedoras, líderes sociales en Latinoamérica)[1], durante los procesos de levantamiento cartográfico/social de experiencias educativas en territorio, explorando la relación de saberes ambientales de frontera, tejidos alrededor de la ciudad y la región en el diálogo cultural-comunicativo, a través de las experiencias de maestros y sabedores regionales, en este caso, de Santander. La pregunta guía fue: ¿Cuáles son las acciones educomunicativas que caracterizan a maestras o sabedoras ambientales en contextos territoriales y flujos migratorios como los dados desde la relación ciudad-región? Algunos resultados permiten revisar dinámicas dadas en un contexto de conflicto, pos-acuerdo y migración interna y externa, que crea saberes ambientales de frontera en las prácticas de formación en Boyacá.

 

[1] El Proyecto Kiva Pedagógica contó con un equipo de docentes de diferentes instituciones, adscritos a la Red Chisua: Mónica Cuineme Rodríguez; Ana Ramírez Cabanzo y Daniel Velásquez; y por la Red de Comunicación Popular: Andrés Castiblanco. Ver: Velásquez, Cuineme, Castiblanco y Ramírez (2019).
El abordaje de cuestiones socioambientales para la formación eco-ciudadana en la educación básica primaria
Authors: Bonilla Mendoza Yaquelin Nayibe , Garzón Barragán Isabel
Published: January 2021

El presente artículo de investigación surge como parte del desarrollo de la tesis doctoral de Yaquelin Bonilla; presenta el diseño e implementación de una unidad didáctica basada en el enfoque metodológico de Investigación Acción Participativa, para abordar la cuestión socioambiental vinculada a la urbanización creciente en las áreas de algunos de los humedales de Bogotá, con el propósito de avanzar en la formación eco-ciudadana de niños, entre 9 y 12 años, del grado 5 de primaria de la IED Tabora, ubicada en la localidad de Engativá, del Distrito Capital.
АНАЛИЗ И ПЕРСПЕКТИВЫ РАЗВИТИЯ АВТОМАТИЗИРОВАННЫХ СИСТЕМ ДИАГНОСТИКИ И МОНИТОРИНГА ТЕХНИЧЕСКОГО СОСТОЯНИЯ ЗДАНИЙ И СООРУЖЕНИЙ
Authors: Наріжний В. В.
Published: January 2021

Деформации зданий в течение их жизненного цикла ксить распространенное явление, особенно на территории городской застройки, где имеет место не только влияние плотнойзастройки, но и уязвимость зданий к повреждениям и продолжительность их эксплуатации.Это порождает новые задачи, связанные с обеспечением безопасной жизнедеятельности в условиях мегаполиса, определяется надежностью строительных объектов, и влияние нового строительства на существующую инфраструктуру. В статье представлены рекомендации иперспективы по внедрению автоматизированных систем мониторинга и диагностики состояния конструкций зданий в режиме реального времени. Рассмотрены прогрессивные направленияповышения эффективности и точности измерения, надежности систем автоматизированногомониторинга с одновременным уменьшением его стоимости. Проанализированы актуальностьвнедрения систем автоматизированного мониторинга деформации зданий на этапе строительства и в течение срока эксплуатации здания. Для проведения контроля и ранней диагностикитехнического состояния оснований и строительных конструкций уникального здания илисооружения предложено автоматизированные стационарные системы мониторинга технического состояния, которые должны обеспечивать в автоматизированном режиме обнаруженияизменения напряженнодеформированного состояния конструкций с локализацией их опасныхучастков, определение уровня крена здания или сооружения, а в случае необходимости и другихпараметров.
ПРОСТРАНСТВЕННАЯ СТРУКТУРА ГОРОДОВ И ОСОБЕННОСТИ ЕЕ ТРАНСФОРМАЦИИ ПОД ВЛИЯНИЕМ НЕМАТЕРИАЛЬНЫЕ (НА ПРИМЕРЕ ГОРОДА КАРПАТСКОГО РЕГИОНА УКРАИНА)
Authors: Косьмій М. М.
Published: January 2021

В статье на основании ретроспективы и анализа теоретических исследованийукраинских и иностранных ученых, раскрыто содержание и эволюцию понятия пространственной структуры города. Впервые модель развития городского пространства сформировал вконце ХIХ Иоганн Генрих фон Тюнен. Процессы интенсивной урбанизации начала ХХ в., привелик появлению социальных факторов влияния на пространственную структуру городов и концепции социального зонирования. В 1939 г. американец Г. Хойт предложил секторальную проекциюгородского пространства, а во второй половине ХХ в. постепенно утвердилась идея "архитектурного кода" У. Эко. Среди современников, наибольший интерес вызывает поиск оптимальнойструктурной модели формирования и развития пространства городов. Это позволяет включитьв пространственную организацию города концепт "свободы", которая важна для рядовогожителя города, который по своему усмотрению предоставляет приоритеты относительномероприятий по обеспечению природной среды, организации транспортной системы, инженерных и производственных коммуникаций. Реализовать это удается с помощью предложеннойМ.Габрелем пятимерной модели пространства.В настоящее время пространственная структура изменяется под влиянием, как материальных,так и нематериальных факторов. Однако, если материальная составляющая города формируется в процессе взаимосвязи существующих стационарных процессов и коммуникационных связей, то нематериальная — дает существующим процессам ценностный аспект, и одновременно выступает одним из элементов коммуникации. Если в материальном смысле коммуникации —это дороги, средства связи, инженернотехнологические сети и др., то нематериальные коммуникации — это вера, а также ассоциативная связанность каждого жителя города, с этимгородом, его пространством, понимание потребностей развития городской территории. Особенно высокие темпы трансформации пространственной структуры под воздействием нематериального демонстрируют города Карпатского региона Украины: ИваноФранковск, Львов,Ужгород, Черновцы.На основании теоретического анализа, а также натурных обследований установлено, что пространство современного города формируется в основном под влиянием нематериального, посколькуопределяющими для настоящего есть идеи культуры, духовности, эстетики.
Reduction in ERCP volume for Acute Cholangitis and other Indications during COVID-19 Pandemic
Authors: Swathi Paleti  , Zain A. Sobani  , Tarun Rustagi
Published: January 2021

Introduction: The COVID-19 pandemic continues to significantly impact healthcare with Joint Gastrointestinal Societies recommending rescheduling elective and non-urgent endoscopic procedures. The aim of our study was to evaluate the trend of acute cholangitis requiring emergent ERCP and overall ERCP practice in the setting of the COVID 19 pandemic.

Methods: A retrospective review of all ERCPs performed at our institution was performed during the study period (3/16/2020 to 4/15/2020) along with the preceding 2 months (1/1/2020 to 2/29/2020) and similar time period from the last 2 years (3/16/2019 to 4/15/2019 and 3/16/2018 to 4/15/2018) for comparison to account for any seasonal variation.

Results: A reduction was noted in absolute number and proportion of ERCPs performed for acute cholangitis during the study period compared to preceding months (2 [6.45%] vs. average 10.5 [15.05%] cases/month; 81% reduction). We also found reduction in overall number of both inpatient and outpatient ERCPs during the study period (31 ERCPs/month to average 70 ERCPs/month; 55% reduction in ERCP volume).

Conclusions: There was a reduction in the overall ERCP volume and number of ERCPs performed for acute cholangitis during the COVID-19 pandemic. Further larger studies are needed to validate this data and investigate its causes.

Keywords: ERCP; COVID-19; SARS-2-Cov; Pandemic; Acute cholangitis; Trend; Biliary
Клинична картина и генетични корелации при български пациенти с мутации на SPATA 5 ген
Authors: Станчева Малина , Тодорова Албена , Тодоров Тихомир , Атемин Славена , Павлова Зорница , Туртуриков Иван , Кадийска Таня , Маринова Евелина , Попова Диана , Аланай Ясмин
Published: January 2021

Синдромът с епилепсия, глухота, умствено изоставане (EHLMRS, OMIM 616577) е рядко заболяване, което се дължи на мутации на SPATA5 гена, локализиран на хромозома 4q28, с автозомно-рецесивно унаследяване. EHLMRS се характеризира с умствено изоставане, рефрактерна епилепсия, микроцефалия, нарушения в мускулния тонус, невро-сензорна глухота. Повечето от пациентите нямат самостоятелна походка, не могат да седят без подкрепа и имат недоразвита реч. Други признаци са проблеми в храненето, изоставане на растежа, кортикални нарушения на зрението, спастицитет, сколиоза, имунен дефицит и тромбоцитопения.

Авторите съобщават за два клинични случая с EHLMRS и нов вероятно патогенен мисенс вариант c.1831C>T на SPATA5 гена.
Гигантски артерио-венозен хемангиом на делтоиден мускул
Authors: Георгиев Александър , Цветкова Силвия
Published: January 2021

Представяме рядък случай на 13-годишен пациент от мъжки пол, източноевропейска популация с оплаквания от болка, дискомфорт и поява на подутина и синина в областта на ляво рамо. След извършена нискодозова компютър-томографска ангиография се доказа гигантски, сегментен, артерио-венозен хемангиом. Предложени са редица хипотези за патогенезата на детските хемангиоми, но точната етиология на тези лезии остава неизяснена. Според широките схващания най-засегнати са индивиди от женски пол в кавказката популация. Хемангиомите често са свързани и с аномалии в развитието и проявяват характерно поведение във времето с фаза на обратно развитие. Макар и доброкачествени, хемангиомите могат да доведат до сериозни и трайни увреди, особено такива, разположени в дълбочина, в близост до кости, ставни междини или паренхимни органи. Предизвикателството пред клиницистите е да разпознаят кои хемангиоми се нуждаят от бдително наблюдение и / или оперативна намеса.
Pengembangan Infrastruktur Komersil Pelabuhan Penyebrangan Ajibata di Kabupaten Toba Samosir Sumatera Utara
Authors: Tondang Bahagia
Published: January 2021

This research is conducted to figure and analyze the infrastructure development of Ajibata Port as the commercial ferry port in Toba Samosir. Ajibata Port is being developed gradually, so it has the potential to be a commercial port which provides facilities and services that can help to increase people’s income and develop the region's economy, by using the community base tourism principle to establish sustainable tourism without damaging the ecosystem or overexploiting. The method that used in this research is the quantitative analysis, thus field observation is needed to collect the reliable data from the local government, business owners, and the communities around Ajibata Port
IMPACT OF MAP DATA QUALITY ON THE USABILITY OF ICT LOGISTICS INFORMATION SYSTEMS
Authors: KALBARCZYK-GUZEK Ewa
Published: January 2021

W artykule omówiono zagrożenia jakie niesie za sobą nieprawidłowa jakość danych mapowych w organizacjach zajmujących się logistyką w kontekście procesów jakie obsługują. Zwrócono uwagę na problematykę błędnych danych adresowych, zarówno na poziomie strategicznym jak i operacyjnym. Wyszczególniono problemy, z jakimi borykają się firmy logistyczne posiadające bazy z błędnie zgeokodowanymi kontrahentami. Opisano dostępne na rynku metody czyszczenia danych oferowane przez wyspecjalizowane przedsiębiorstwa rynkowe.
OPTIMAL FOOD PROTECTION OF THE MECHANIZED BATALION IN DEFENSE ACTIVITIES DETERMINANT OF PROPER PERFORMANCE OF TASKS
Authors: KLER Paweł , SZCZYGIELSKI Bartosz
Published: January 2021

W artykule zaprezentowano koncepcję zabezpieczenia żywnościowego batalionu zmechanizowanego w działaniach obronnych. Dokonano tego przez zidentyfikowanie obszaru procesu organizacji żywienia żołnierzy na szczeblu batalionu w czasie działań taktycznych, przedstawienie możliwości żywienia wojsk na szczeblu batalionu w działaniach obronnych oraz zaprezentowanie optymalnej koncepcji zabezpieczenia żywnościowego batalionu w założonej sytuacji działań taktycznych. W wyniku przeprowadzonych rozważań wypracowano wnioski końcowe, które jednoznacznie wykazują zależność między optymalnym zabezpieczeniem pod względem żywnościowym batalionu zmechanizowanego w obronie a bezpieczeństwem wykonania postawionych przed dowódcą batalionu zadań bojowych.
APPLICATION OF HYBRID NEURAL NETWORK SYSTEM IN IMAGE PROCESSING
Authors: RYKAŁA Łukasz
Published: January 2021

The article describes the use of feedforward two-layer neural network and recursive neural network with feedback, i.e. Hopfield network within a system capable of performing associative memory functions. It has been shown that these structures can be used successfully alone, however, using them together in series in the listed above order significantly improves system performance.
APPLICATION OF ARIMA MODEL FOR FORECASTING PRODUCTION QUANTITY IN ENTERPRISE
Authors: GRZELAK Małgorzata
Published: January 2021

Celem przedsiębiorstw produkcyjnych jest zaspokajanie potrzeb klientów, poprzez terminowe wytwarzanie wyrobów zgodnie z popytem występującym na rynku. Powyższe działania umożliwiane są przez prawidłowe sporządzanie prognoz potencjalnych zamówień. W poniższym artykule przedstawiono model ARIMA jako narzędzie wspierające planowanie wielkości produkcji w przedsiębiorstwie. Dokonano również oceny wiarygodności opracowanego modelu poprzez analizę reszt oraz ich autokorelacji i autokorelacji cząstkowych.
PROBLEMS OF ORDER-PICKING REPLENISHMENT IN DISTRIBUTIONAL WAREHOUSES
Authors: LEWCZUK Konrad , ŁAJSZCZAK Marcin
Published: January 2021

Proces kompletacji jest podstawowym czynnikiem kosztotwórczym i determinantą jakości w procesie magazynowym w łańcuchu dostaw. Efektywna kompletacja wymaga odpowiedniego układu technologicznego, dopasowanego do realizowanego zadania logistycznego, oraz strategii uzupełniania obszaru kompletacji, która będzie jednocześnie efektywna kosztowo i będzie zapewniała terminową realizację zadań kompletacji. W artykule przedstawiono problematykę uzupełniania obszarów kompletacji i omówiono podstawowe elementy strategii uzupełniania w odniesieniu do aktualnego stanu wiedzy.
THE POSSIBILITIES OF MODERNIZATION OF LAND FORCES' ARMAMENT SYSTEMS IN TERMS OF LOGISTIC REQUIREMENTS
Authors: FIGURSKI Jan , NIEPSUJ Jerzy
Published: January 2021

W artykule przedstawiono zasadnicze uwarunkowania zmierzające do prowadzenia prac modernizacyjnych systemów uzbrojenia eksploatowanych w wojskach lądowych. Jako kryterium modernizacji przyjęto uwarunkowania czasowe, niezawodnościowe oraz parametry funkcjonalne sprzętu eksploatowanego w armiach „strony przeciwnej”. W procesie tym uwzględniono również uwarunkowania związane z efektywnością prac modernizacyjnych rozumianych jako uzyskiwanie korzyści w odniesieniu do ponoszonych nakładów. Szczególną uwagę w procesie modernizacji poświęcono modernizacji wynikającej z funkcji niezawodności doskonalonego systemu i jego gotowości do wykonywania zadań. Przedstawiono uwarunkowania modernizacyjne wynikające ze struktury szeregowej i równoległej. W końcowej części artykułu przedstawiono praktyczne potrzeby modernizacji broni strzeleckiej i wybranych typów broni artyleryjskiej, w tym rakietowej. Proces modernizacji powinien być prowadzony w krajowym przemyśle obronnym (w rodzimym przemysłowym potencjale obronnym). Przemysł ten powinien dysponować nowoczesnymi technologiami modernizacyjnymi.
FORECASTING OF TOTAL REVENUES IN THE JIT FOR 2020
Authors: KOZICKI Bartosz , ĆWIEKOWSKI Łukasz , KOSZAREK Artur
Published: January 2021

W artykule został sformułowany problem badawczy dotyczący analizy, oceny i prognozowania przychodów całkowitych przedsiębiorstw JIT (Logistic Just in Time) w ujęciu miesięcznym na rok 2020. Przeprowadzono analizę literatury przedmiotu badań dotyczącą przychodów oraz prognozowania. Badania rozpoczęto od nakreślenia wykresu liniowego danych pierwotnych. Oceną obserwacji wzrokowej było zaobserwowanie tendencji w postaci trendu i sezonowości. Użytymi w artykule narzędziami badawczymi potwierdzono istnienie prawidłowości w rozpatrywanych danych retrospektywnych. Krytyczna analiza literatura dotycząca prognozowania, pozwoliła na wybór metody wygładzania wykładniczego Holta-Wintersa do prognozowania danych pierwotnych na przyszłość. Uzyskane prognozy zostały poddane analizie i ocenie.
ELECTRONIC CONTROL OF LOCAL UNIFORMITY OF ILLUMINANCE FROM POWER LED
Authors: LISOVENKO Valentin , LISOVENKO Denys Valentynovych , BAZIK Oleksandr , SHMELEV Yurii , BYŁEŃ Sławomir
Published: January 2021

It has been suggested to assess non-uniformity of illuminance by the coordinate distribution of its gradient. By the example of mathematical model, the possibility to form a desired illuminance gradient profile from a multicomponent module by means of electronic control of the LED lighting parameters.
TRANSPORT ANIMALS AND MEAT IN THE EUROPEAN UNION
Authors: SIECZKA Jarosław , KUKIER Agnieszka
Published: January 2021

W artykule przedstawiono problematykę międzynarodowego transportu zwierząt i mięsa. Głównym celem było porównanie ekonomiczności obu transportów i zaproponowanie sposób usprawnienia tych procesów. Niezwykle ważnym etapem tych działań była współpraca z firmami działającymi aktualnie na rynku.
Dakwah Pasca Covid 19
Authors: Taufik Ahmad
Published: January 2021

In preaching, there are important things which are also factors of success or failure of preaching, namely motivation. Motivation is important and the subject of everything. In motivation, it contains three main components, namely moving, directing and supporting human behavior. In other words, motivation directs individual behavior towards a goal to maintain and support the behavior, while the environment must strengthen the intensity and direction of individual encouragement.
A study of distortion correction algorithms based on aspheric fisheye lens design
Authors: Dan Li  , Baolong Zhang  , Jiawei Zhu  , Qi Wang  , Zhenwei Zhu
Published: January 2021

A design method of aspheric fisheye lens has been proposed in this paper, based on the requirements of automobile surround view system. The study has designed a kind of ultra-wide-angle fisheye lens, which only consists of a spherical glass lens and three aspherical plastic lenses. The maximum diameter of imaging aperture is 15.3 mm; the working distance behind is 2.158 mm; the total length of system is 11.44 mm; the focal length is 0.97 mm; the viewing angle is 210°, and the modulation transfer function (MTF) curve is 0.35 at 60 lp/mm. Furthermore, a kind of a distortion correction algorithm for fisheye lens has been created, which calculates the position of the ideal image point with the actual image point and the obtained distortion curve and distortion model. The algorithm can correct the distorted image taken by a fisheye lens to an image without distortion, which is suitable for the human eye. The algorithm, which is simple and effective, has been applied to the automobile surround view system. It has been verified to be accurate and reasonable, after the comparison is made between the real image taken by a fisheye lens and the corrected image.
Research on the X-ray wavelength division multiplexing technology for blackout region communication
Authors: Yao Li  , Tong Su  , Lizhi Sheng  , Neng Xu  , Baosheng Zhao
Published: January 2021

After the concept of X-ray communication was proposed, its application in complex electromagnetic environment has received more attention, such as data transmission in re-enter special electromagnetic condition. In this article, a new type of X-ray source was introduced firstly, which was expected to generate multiple characteristic lines and achieve wavelength division multiplexing technology in X-ray band. Then an experimental platform was built for analyzing transmission characteristics of X-ray photon in various plasma media. Finally, the calculation model for a link power equation was given. Experiment results show that transmittance of 8–18 keV X-ray signal is relatively stable, atomic numbers from 29 to 42 are the most suitable materials for wavelength division multiplexing, the X-ray communication system is expected to realize about 200 kbps data transmission rate in adjacent space.
Virtual MRTD – an indirect method to measure MRTD of thermal imagers using computer simulation
Authors: Chrzanowski Krzysztof , Nguyen Hong Viet
Published: January 2021

Minimum resolvable temperature difference (MRTD) is considered as the most important parameter of thermal imagers. A new method of MRTD measurement without drawbacks of other methods is presented in this paper. Proposed MRTD measurement method coded as virtual MRTD is based on a three steps measurement concept using semi-automatic objective measurements and computer simulation. First, objective parameters of the tested thermal imager are measured. Second, software simulates this tested thermal imager and generates the image of 4-bar target of specified spatial frequency (size) and contrast (temperature difference). Third, a human observer analyses the images of the 4-bar target generated by the software on the screen of PC set and measures MRTD of the simulated thermal imager at specified set of spatial frequencies. The proposed method offers higher measurement speed, lower cost and typically better accuracy in comparison with the typical MRTD measurement method.
Lebende Antiquitäten? Die ,,Native Americans“ Nordamerikas, die Universalgeschichte und die Archäologie
Authors: Sawilla Jan Marco
Published: January 2021

Das historische Denken war universal, solange es sich auf einen universalen Gegenstand beziehen konnte, den Menschen. Es war universal und in diesem Sinne integrativ, solange es vonnöten schien, sich darüber zu verständigen, ob die Menschen einen gemeinsamen Ursprung
besaßen und ob es möglich sei, sich gegenseitig an Handlungsweisen oder Zeichensystemen zu erkennen, die unterschiedliche Zeiten und Formen der Vergemeinschaftung transzendiert hatten.2 Es war universal, solange gentile oder ethnische Differenzen nicht – wie im
biologischen Rassismus des 19. Jahrhunderts3 – essenzialisiert wurden und in diachronischer Hinsicht der vergleichsweise kompakte Bezugsrahmen der biblischen Chronologie nicht derart überschritten wurde, dass die Geschichte der Menschheit nur noch einen Bruchteil dessen
ausmachte, was naturkundliche Gelehrte wie Georges Cuvier (1769–1832), William Buckland (1784–1856) oder Louis Agassiz (1807–1873) – um hier nur sie zu nennen – seit den ersten Jahrzehnten des 19. Jahrhunderts als Geschichte der Erde und ihrer Formationen zu begreifen
suchten.4
Utilizing Field Theory to Examine Mega-event-led Development
Authors: Duignan Michael B.
Published: January 2021

Scholars and practitioners have long been analyzing and evaluating the way events, particularly mega-events, serve as a mechanism of change. Powerful descriptions are typically brought to life via event impact and legacy case studies: yet, I argue such work can remain atheoretical—or—conceptually
disorganized. I draw on Bourdieu's field theory and the management study of Field Configuring Events to develop a new analytical framework: the "Cognitive and Relational Mapping of Field Configuring Events"—offering a set of interrelated concepts to strengthen
analysis and conceptual consistency between studies, while providing latitude to overlay different disciplinary perspectives. I detail methodological and conceptual advantages afforded alongside six ways the framework could be applied and extended across various cases and contexts.
Analysis of the lists of drugs for the treatment of patients with malignant neoplasms for the possibility of using these drugs on an outpatient basis
Authors: Linnik Sergei , Zudin Alexandr , Shepin Vladimir , Alexandrova Oxana
Published: January 2021

The increase of the state funding of the provision of cancer medicines actualizes the question of access to treatment. This research provides an analysis of the of cancer medicines purchasing and the possibilities of using these medicines on an outpatient basis in frame of state healthcare system
Pilot project for screening cervical cancer using HPV testing
Authors: Minniakhmetov Ildar , Zabelin Maksim , Olkov Iliya , Khusainova Rita
Published: January 2021

The results of a large-scale pilot project on HPV-testing by the Hybrid Capture technology (digene HC2 HPV DNA Test) of 28928 women in the Republic of Bashkortostan were summarized. The frequency of high-risk HPV infection in the studied region of Russia was 10.6%, the average viral load was 319.97 RLU / COV ratio in the total sample, which corresponds to a high viral load (more than 3x107 genomic equivalents). In 5.4% of HPV-positive women, cervical pathology was revealed, cervical cancer in the early stages was detected in 21 (0.69%) women (20 cancer in situ and 1 cancer IA).
Epidemiology, index of accuracy, histological structure, year-by-year lethality and survival of patients with malignant melanoma. Population study – part II
Authors: Merabishvili Vakhtang , Merabishvili Elvira
Published: January 2021

For any research development, we must first make sure that the material selected for research is reliable. Among the six main most reliable criteria for evaluating the performance of cancer services, such as morbidity, mortality, and the level of morphological verification of tumors – the most important indicators are the index of accuracy, primary mortality and survival of patients with malignant tumors.

Purpose. To determine the level of index of accuracy for patients with skin melanoma (C43) and its dynamics from 1995 to 2018 in Russia as a whole and in a number of administrative territories. Calculate the 5-year observed and relative survival and typical mortality in the northwestern Federal district of the Russian Federation.

Materials and methods of research. The material for the study is statistical collections, including author's ones, and the database of the cancer register of the northwestern Federal district of the Russian Federation. Standard methods of statistical analysis were used.

Obtained result. It is important to note that for all administrative territories, whose PCR database were involved in calculating the 5-year observed and relative survival rates, the level of survival rates of patients with melanoma of the skin is significantly lower than the average European (Eurocare–4).

Conclusions. Thus, the study revealed a significant improvement in the treatment of patients with malignant melanoma of the skin. At the same time, the estimated 5-year observed and relative survival rates of patients with malignant melanoma of the skin remain relatively low.
Results of successful treatment of uterine malignant neoplasms in patients with a severe comorbid status (clinical cases)
Authors: Dikareva Elena , Игорь Говоров  , Komlichenko Eduard , Pervunina Tatyana , Ulrikh Elena
Published: January 2021

In Russian Federation, as in other developed countries, endometrial cancer (EC) is the most common malignant tumor within the female reproductive system. Over the past decades, patients with EC more often present with severe comorbidities. They require an individual management approach through the perioperative period in order to prevent possible complications. We performed the analysis of the surgical treatment of 17 patients with endometrial cancer with multiple comorbidities that were treated in Almazov National Medical Research Centre for the period from 01.01.2019 to 30.04.2020. Majority of patients (52.9%)  exceeded 6 points of Charlson index, indicating the presence of 3 or more severe somatic diseases. Due to multidisciplinary treatment approach (including oncologists, cardiologists, cardiac surgeons, intensive care specialists, rheumatologists, and others) radical surgery was performed in all patients.
Clinical and genetic features in patients with MutYH-associated polyposis
Authors: Toboeva Margarita , Pikunov Dmitrii , Tsukanov Aleksei , Frolov Sergei
Published: January 2021

Aim. MutYH-associated polyposis is a rare polyposis syndrome with an autosomal recessive type of inheritance, phenotypically often similar to an attenuated form of Familial adenomatous polyposis (FAP). In different populations, patients with MAP have clinical and genetic features. The article presents the features of the clinical picture and the spectrum of mutations in the MutYH gene in patients with MutYH-associated polyposis in the Russian population.

Materials and methods. The material for the study was clinical data of 20 patients with a genetically confirmed diagnosis of MutYH-associated polyposis underwent treatment at National Medical Research Centre for Coloproctology named after A.N. Ryzhikh».

Results. The male to female ratio among patients with MAP was 7:13. The average age of diagnosis was 49.7 (19-70) years. The average number of polyps in the colon was 91 (24-420), while in most patients (70%; 14/20) they were distributed evenly in all parts of the colon, in 6 patients, most were located in the right sections. The most common pathogenic mutations in the MutYH gene were missense mutations p.G382D (33%; 13/40), p.Y165C (15%; 6/40), p.G169D (15%; 6/40) and p .R231H (15%; 6/40), also found in two patients c.462 + 19_462 + 31del. The frequency of other mutations that occurred only once was 17% (7/40). It was revealed that 12 out of 20 patients (60%) had colorectal cancer (CRC) at the time of MAP diagnosis, while the average age for diagnosing MAP without CRC was 37.5 (19-50) years, and the average age of CRC diagnosing for patients with MAP background - 57.9 (42-70) years.

Conclusions. Clinical and genetic characteristics of patients with MutYH-associated polyposis were identified in the Russian population.
Five-year results of combined radiation therapy for high-risk prostate cancer
Authors: Novikov Sergei , Kanaev Sergei , Novikov Roman , Gafton Georgii , Gotovchikova Mariya , Hirschovich Mikhail , Melnik Juliya , Ilyin Nikolai , Merezhko Juriy
Published: January 2021

The purpose of the study is to assess the effectiveness and toxicity of the treatment of prostate cancer (PCa) with combined radiation therapy (CRT), where high dose rate brachytherapy (HDR-BT) "boost".

Materials and methods: CRT was carried out in 98 patients of high-risk and extremely high-risk PCa. External part of treatment (conformal external radiation therapy) provided total dose 46-50 Gy with a single focal dose (SFD) 2 Gy to the prostate gland (PG), seminal vesicles and regional lymphatic zones. Two regimes of "boost" to the PG and seminal vesicles were used: in the first group – two fractions of 10 Gy (81 patients), in the second - 15 Gy (17 patients).

Results: median follow-up equals: I group - 57.5 months, II group - 55.2. Three- and five-year survival without biochemical progression in group I - 75.4% and 69.0%, II group - 76.4% and 52.9%, respectively. Similar indicators regardless of the CRT regime in groups of different risk of relapse were equal: high risk - 84.6% and 75.9%, extremely high risk - 69.4% and 60.7%, respectively (p=0.05).

There were no late radiation genitourinary and gastrointestinal complications of 4-5 degrees. The most significant variants of late disorders were the formation of urethra stricture (one patient of the I group) and stenosis of the rectum (one patient of the II group). Late genitourinary radiation toxicity (L-GURT) was mainly represented by changes that can be characterized as 1 degree (RTOG/CTCAE): I group - from 40.6% to 53.2%, II - 18.8% to 35.3%.

Conclusions: the studied CRT regimes showed perfectly acceptable survival rates with no signs of biochemical progression and radiation toxicity during the five-year period of follow-up.
Nivolumab-induced endocrinopathy
Authors: Odin Vitalii , Tishko Valerii , Klimenko Viktoriya , Shcherbatyuk Oksana , Vasilyev Mikhail , Tyrenko Vadim
Published: January 2021

Inhibitors of immune control points (ICP) is a new group of drugs used to treat patients with incurable neoplasias, in particular their metastatic forms. However, there is a risk of developing immune-mediated adverse events from a number of organ systems during therapy with these drugs. Immune-mediated adverse events are understood as a side effect due to excessive activation of the immune system with autoimmune damage to normal tissues of various organs and systems, and not the main goal of immunotherapy. In particular, one of these side effects when using ICP is the development of endocrinopathies (thyroiditis, hypophysitis, adrenalitis, type 1 diabetes mellitus). We present a literature review and a clinical case of the development of hypothyroidism, hyponatremia and psychosis in a patient after nivolumab therapy for recurrent colorectal cancer 3 months after immunotherapy.
On the osteology and phylogenetic affinities of Morsoravis sedilis (Aves) from the early Eocene Fur Formation of Denmark
Authors: Mayr Gerald
Published: January 2021

Morsoravis sedilis is a small bird from the early Eocene Fur Formation of Denmark, which in the original description was considered to be most closely related to Charadriiformes. Because Morsoravis has subsequently been likened to Pumiliornis tesselatus, an equally enigmatic bird from the middle Eocene of Messel in Germany, I perform here the first phylogenetic analysis including the two taxa.

This analysis supports a sister group relationship between Morsoravis and Pumiliornis, and the clade including the two taxa is recovered as the sister taxon of the late Eocene/early Oligocene Eocuculus.I report a possible, albeit lost, second specimen of Morsoravis, and identify derived characters in support of a sister group relationship between Morsoravis and Pumiliornis.

The analysis did not resolve the higher-level affinities of the clade including Morsoravis, Pumiliornis, and Eocuculus, and did not confirm charadriiform affinities of Morsoravis. More data on the osteology of the fossils, as well as an improved understanding of the interrelationships of extant birds, are needed for a well-established phylogenetic assignment of these fossil taxa.
Bite traces in a turtle carapace fragment from the middle Danian (Lower Paleocene) bryozoan limestone, Faxe, Denmark
Authors: Milan Jesper , Lindow Bent E.K. , Lauridsen Bodil W.
Published: January 2021

A fragment of a turtle carapace from the Middle Danian bryozoan limestone at the Faxe quarry, eastern Denmark, is identified as a partial costal plate from the carapace of a chelonioid turtle. The fragment bears traces of three separate acts of predation or scavenging.

Two circular bite traces Nihilichnus nihilicus Mikuláš et al. 2006, 4 mm in diameter, situated 2.5 cm apart, are interpreted as crocodylian. Groups of parallel scrapes, Machichnus bohemicus Mikuláš et al. 2006, 4–5 mm long and 0.5 mm wide, are interpreted as bite traces from sharks. Small circular traces, ~1 mm in diameter, found either alone or in a row of three, are either from sharks or fish.

This is the first record of turtles from the Danian bryozoan limestone exposed in Faxe quarry, and thus represents an important addition to the Danian vertebrate fauna of Denmark.
Rare finds of the coiled cephalopod Discoceras from the Upper Ordovician of Bornholm, Denmark
Authors: Rasmussen Jan Audun , Surlyk Finn
Published: January 2021

Coiled nautiloid cephalopods of the genus Discoceras are locally common in the Middle and Upper Ordovician of Baltica, for example in the Oslo Graben, but are exceedingly rare in contemporaneous strata from the Danish island of Bornholm.
The two new species of Discoceras described here, D. costatum n. sp. and D. vasegaardense n. sp., occur in shales of the Upper Ordovician Lindegård Formation. The nautiloids are preserved as external molds in laminated siliciclastic mudstones.
The very rare occurrence of cephalopods, combined with the apparently endemic nature of the Discoceras fauna, may be explained by the location of Bornholm distally on the Baltoscandian shelf combined with the influence of relatively cold ocean currents from the adjacent Rheic Ocean.
The middle Danian Faxe Formation – new lithostratigraphic unit and a rare taphonomic window into the Danian of Denmark
Authors: Lauridsen Bodil Wesenberg , Surlyk Finn , Bjerager Morten
Published: January 2021

The new middle Danian Faxe Formation is defined on the basis of the succession exposed in the large Faxe quarry in eastern Denmark. The formation is defined as a distinct mappable ithostratigraphic unit of interfingering coral and bryozoan limestone passing laterally into bryozoan limestones of the Stevns Klint Formation.

The Baunekule facies is recognized in the upper part of the coral mound complex of the Faxe Formation, where it forms isolated lensoidal bodies in the flanks of some of the coral mounds. It is characterised by a high diversity invertebrate fauna with both calcite and originally aragonite-shelled benthic invertebrates set in weakly consolidated coral-dominated floatstone to rudstone.

The diagenesis of the Baunekule facies is of special significance because a high proportion of the originally aragonite-shelled fauna is preserved by recrystallization to calcite during early burial diagenesis. More than 80% of the species from the Baunekule facies are unknown from other parts of the Faxe Formation.

The carbonate mud matrix is only slightly consolidated and the invertebrate fossils are accordingly easy to prepare in contrast to the fossils from the lithified parts of the Faxe Formation, which are commonly only preserved as moulds or casts. The facies therefore presents an exceptional taphonomic window into a cold-water coral mound fauna, giving an unusually complete picture of the diversity and density of the shelly invertebrate fauna.
Active longevity: long-term clinical observation
Authors: Zhdanov R. I. , Khabibullin I. M. , Khammatova E. F. , Aidarov V. I. , Zhdanova S. I. , Dvoenosov V. G. , Khairullin R. N.
Published: January 2021

Objective.The work is aimed to analyze the biochemical and lipid blood profile of patient Z and to evaluate the effect of a long-term garlic (Allium sativum L.) — based diet on aging-associated processes and slowing down pathological processes in heart-vessels system.Materials and methods.Blood profiles of the patient Z are studied which represents seventythree years old physically active man with intellectual professional activity who played lawn tennis twice a week for the 45 years and followed a consistent vegetarian diet without any meat and milk products (for 32 years), and a garlic-based diet for the last 11 years. The garlic diet represents uptake of one head of raw garlic every day orally (totally 25–30 g, e.g., 1 g of raw garlic per 3 kg of body weight 5–6 days a week) for 11 years. General, biochemical and lipid blood tests were examined during 15 years.Results.Laboratory blood tests of 2003 are testified the ill-being at the level of lipid profile and heart-vessels system as a result of pathological conditions and aging. As a result of garlic intake starting from 2007, blood biochemical profile is started to testify that negative changes at the patient Z’s organism are slowed, levels of cholesterol, triglycerides, lipoproteins, creatinine and endotoxin being normalized. As a result of long-term garlic intake the stabilization of indicators of his organism systems was found: namely, the molecular and cellular blood composition, the neck and head vessels, and a high adaptive and reproductive resource of the organism.Conclusion.After the introduction of the garlic diet in 2007, blood tests and ultrasound examinations of the body blood vessels indicate that, despite of age and refusal to take pharmaceuticals, the triglyceridemia and hypercholesterolemia diagnoses have been withdrawn; hypertension has stopped progressing, and arterial blood pressure is stabilized. It is assumed that the bioactive components of garlic exhibit bioantioxidant and geroprotective properties and enhance tissue regeneration. Thus, a garlic-based diet may be recommended to reduce the effects of environmental stressors and to slow down the aging-associated processes.
Supramolecular polymerization of sulfated dendritic peptide amphiphiles into multivalent L-selectin binders
Authors: Straßburger David , Herziger Svenja , Huth Katharina , Urschbach Moritz , Haag Rainer , Besenius Pol
Published: January 2021

The synthesis of a sulfate-modified dendritic peptide amphiphile and its self-assembly into one-dimensional rod-like architectures in aqueous medium is reported. The influence of the ionic strength on the supramolecular polymerization was probed via circular dichroism spectroscopy and cryogenic transmission electron microscopy. Physiological salt concentrations efficiently screen the charges of the dendritic building block equipped with eight sulfate groups and trigger the formation of rigid supramolecular polymers. Since multivalent sulfated supramolecular structures mimic naturally occurring L-selectin ligands, the corresponding affinity was evaluated using a competitive SPR binding assay and benchmarked to an ethylene glycol-decorated supramolecular polymer.
Supramolecular polymers with reversed viscosity/temperature profile for application in motor oils
Authors: Ostwaldt Jan-Erik , Hirschhäuser Christoph , Maier Stefan K , Schmuck Carsten , Niemeyer Jochen
Published: January 2021

We report novel supramolecular polymers, which possess a reversed viscosity/temperature profile. To this end, we developed a series of ditopic monomers featuring two self-complementary binding sites, either the guanidiniocarbonyl pyrrole carboxylic acid (GCP) or the aminopyridine carbonyl pyrrole carboxylic acid (ACP). At low temperatures, small cyclic structures are formed. However, at elevated temperatures, a ring–chain transformation leads to the formation of a supramolecular polymer. We demonstrate that this effect is dependent on the concentration of the solution and on the polarity of the solvent. This effect can counteract the loss of viscosity of the solvent at elevated temperatures, thus opening an application of our systems as viscosity index improvers (VIIs) in working fluids. This was tested for different motor oils and led to the identification of one compound as a promising VII.
Competitiveness of Ukraine's economy: what factors interfere with its development
Authors: HURALSKA Viktoriia , SHARKOVA Hanna , KOVTUNENKO Kseniia
Published: January 2021

Introduction. Today, the competitiveness of the national economy is one of the most influential concepts of development economics and practical policy, because it not only covers purely economic indicators, but also evaluates the economic results of non-economic phenomena important for stable growth, such as quality of political processes and governance. education, scientific base, rule of law, culture, value system, information structure. There are many scientific papers in the world that study the competitiveness of countries in the context of globalization. This problem was studied in detail by P. Krugman, E. Warner, J. Keynes, R. Barro, M. Porter, and J. Schumpeter. Despite such a large number of studies, the problems of forming the country's competitiveness still remain unsolved and not sufficiently substantiated.
The purpose of the paper is to analyze the level of competitiveness of the economy of Ukraine and its regions, to identify factors that hinder development.
Result. The key to Ukraine's high competitiveness at the international level is to increase the efficiency and productivity of the diversified national economy, which must be based on a strong technological, scientific and investment base. The current level of budget funding for education is devoid of investment, does not provide reliable development and modernization of education. Domestic business structures have not yet realized that investing in education is one of the most profitable areas of investment. The strategic task for Ukraine at the present stage should be the priority development of science and high technologies and active innovation policy. Innovation is the potential for economic growth.
Conclusion. Only through the intensification of economic activity will Ukraine be able to integrate into the world community, ensure the necessary level of economic security and well-being of citizens. To ensure competitiveness, it is necessary to reorient financial resources from current consumption to investment and direct investment activities to the formation of an efficient national economy, in particular, to innovate investments, intensify innovation as a priority component of socio-economic development strategy.
Methodological aspects of evaluation of competitiveness of the enterprise
Authors: OLEINYKOVA Olena , PANCHENKO Mariia , HINDA Tetiana
Published: January 2021

Introduction. In modern conditions of formation and development of market relations before each enterprise there is a problem of an estimation of a level of competitiveness in order to strengthen a competitive position and to offer effective directions of increase.
The purpose of the paper is to analyze the methodological foundations of the competitiveness of the enterprise as a starting point for further development, the ability to achieve strategic goals and objectives.
Results. Modern approaches and practical recommendations aimed at determining the essence of assessing the competitiveness of the enterprise are substantiated. Emphasis is placed on the importance of enterprise competitiveness in the overall economic development of the country. The sequence of actions during the assessment of product competitiveness is offered. The methodological aspects of assessing the competitiveness of the enterprise are determined, the classification of methods of assessing the competitiveness and the choice of the optimal method are given.
Conclusion. Improving the state of the country's economy cannot happen without increasing the competitiveness of enterprises themselves. Proper assessment of the company's competitiveness allows management to identify key competitors, analyze their behavior strategy, see their own place in the market and develop their own strategy for further behavior to neutralize competitors and increase their profits.