bluuebunny/crossref_metadata_2025 huggingface dataset:
The results of ocrelizumab therapy in patients with multiple sclerosis in the Voronezh region
Authors:   Burdenko Voronezh State Medical University, Bykova Valeriya A. , Ermolenko Nataliya A. ,   Burdenko Voronezh State Medical University, Krasnorutskaya Olga N. ,   Burdenko Voronezh State Medical University, Khoroshikh Anna O. ,   Burdenko Voronezh State Medical University, Yazova katerina A. ,   Burdenko Voronezh State Medical University, Tkachenko Nataliya V. ,   Voronezh Regional Clinical Hospital No 1, Bragina Oxana V. ,   Voronezh Regional Clinical Hospital No 1
Published: June 2024

Aim. Analysis of own results of ocrelizumab therapy in patients with multiple sclerosis (MS) in the Voronezh region. Materials and methods. This work was a cross-sectional study based on the Voronezh Regional Clinical Hospital № 1. The study included 61 patients (34 women and 27 men) with MS with an average age of 38.5±2.6 years. All patients received ocrelizumab (Ocrevus) intravenously according to the scheme: an initial dose of 300 mg with an interval of 2 weeks, then 600 mg every 6 months. The effectiveness of therapy was assessed according to the NEDA-2 (no evidence of disease activity), NEDA-3 and NEP (no evidence of progression) criteria. Results. Ocrelizumab has shown high efficacy in stopping the progression of all considered types of MS. The NEDA-2 and NEP criteria were achieved by the patients as early as 6 months after the start of therapy. NEDA-3 criteria for highly active MS – by 12 months of therapy, for secondary progressive MS with exacerbations – by 18 months of therapy. The highest efficiency of treatment with ocrelizumab was shown in the group of patients with highly active MS, where not only the cessation of disease progression was noted, but also a significant decrease in the degree of disability according to the EDSS scale. Conclusion. It is necessary to start therapy with ocrelizumab at an earlier time: in primary progressive MS immediately after confirmation of the diagnosis, in relapsing MS – when signs of high disease activity and/or suboptimal response to the first of the drugs of disease modifying treatment appear. Timely initiation of ocrelizumab treatment may avoid severe disability in patients.
The preparation Neurexan® for the treatment of anxiety disorders in multimorbid patients. Resolution of the Council of Experts (October 27, 2023)
Authors:   Burdenko Voronezh State Medical University, Ermolenko Nataliya A. , Bykova Valeriya A. ,   Burdenko Voronezh State Medical University, Ulyanova Olga V. ,   Burdenko Voronezh State Medical University, Tribuntseva Lyudmila V. ,   Burdenko Voronezh State Medical University, Troshina Olga V. ,   Voronezh Regional Clinical Hospital No 1
Published: June 2024

Stress disorders are a global public health problem, having a significant impact on patients and society. Chronic stress can lead to long-term consequences, including mental and physical illness. The body's first response to acute stress is characterized by the appearance of anxiety, but beyond a certain level, anxiety becomes maladaptive. Anxiety worsens the quality of life and adaptation of patients, complicates the course of comorbid pathology and its diagnosis. In the review anxiety disorders in patients with multiple sclerosis, Parkinson's disease, and chronic pain syndromes discussed. A significant deterioration in the course and prognosis of the neurological disease in combination with anxiety disorders in multimorbid patients has been shown. Treatment of anxiety includes psychotherapy, the use of antidepressants, and short courses of benzodiazepines. Neurexan® as the safe and effective drug that does not interact with other drugs and has a favorable tolerability profile can be recommended to patients with multimorbid pathologies to correct emotional disorders, reduce anxiety and improve sleep.
Tremor as the onset of dystonia
Authors:   Sklifosovsky Research Institute of Emergency Medicine, Yakhyaeva Sabiyat A. , Zavaliy Lesya B. ,   Sklifosovsky Research Institute of Emergency Medicine, Ramazanov Ganipa R. ,   Sklifosovsky Research Institute of Emergency Medicine
Published: June 2024

The diagnosis of tremor is an important medical problem because its clinical variability defines a differential range of diseases. The purpose of this article is to provide a practicing neurologist with screening approaches to diagnosing tremor using a clinical case as an example.
Role of menopausal hormone therapy in the issues of preventing cardiovascular disorders in women in their post-reproductive stage
Authors:   Kazan State Medical Academy – branch of Russian Medical Academy of Continuous Professional Education, Kazan, Russia, Mazitova adina I. ,   Institute of Health and Longevity ",   Razumed, Mardieva Rezeda R. ,   Kazan State Medical Academy – branch of Russian Medical Academy of Continuous Professional Education, Kazan, Russia; City Clinical Hospital No7, Faustova Karina V. ,   Kazan State Medical Academy – branch of Russian Medical Academy of Continuous Professional Education
Published: June 2024

Cardiovascular disorders (CVD) in female population are the main cause of mortality, and an increase in the prevalence of myocardial infarction among women is observed in the recent decades, in contrast to the male population showing a decrease in this indicator. Certainly, the mechanisms underlying CVD in people of different sexes have much in common, however, one cannot ignore the differences associated with fundamental genetic determinants of ageing, different characteristics of metabolism and fundamentally different types of hormonal status. It has been found that realization of activity of sex hormones is among major factors ensuring protection against cardiovascular disorders in premenopausal women. The increase in the rate of cardiovascular disorders and the lack of menopausal hormone therapy (MHT) prescription to women in their post-reproductive stage may be partially correlated. Aim. To analyze the data provided by advanced scientific research focused on prescription of menopausal hormone therapy (MHT) aimed at preventing cardiovascular disorders in the post-reproductive period. Methods. Analytical review of domestic and foreign papers on the topic, including using PubMed, Elseviewer, Cochrane library, Elibrary databases. Conclusions. Despite the fact that the issue of prevention and treatment of cardiovascular disorders attracts particular attention of global healthcare, CVDs still rank first in the world as the cause of deaths. In menopausal women, hypoestrogenism is among major pathogenetic links of cardiac abnormalities. To increase adherence of peri- and postmenopausal women to early diagnosis, general practitioners should give due consideration to referral of such women to obstetricians-gynecologists for timely correction of estrogen deficiency. It is also necessary to further study the issue in order to identify early diagnostic predictors of cardiovascular disorders.
Role of self-monitoring of blood glucose in adolescents with type 1 diabetes mellitus: case study
Authors:   Ivanovo State Medical Academy, Batrak Galina A. , Skedina Alena O. ,   Ivanovo State Medical Academy
Published: June 2024

Type 1 diabetes mellitus (dm) is a disease characterized by chronic hyperglycemia and the development and progression of severe microvascular complications. The results of the AdVAnce, Accord and VAdT large-scale research studies have definitely proved that glycemic control plays a role in prevention of the dm microvascular complications. A number of studies have shown that glycemic variability parameters play a separate role in prediction of diabetic retinopathy, nephropathy and cardiovascular complications. Adolescents with type 1 dm are characterized by the labile disease course and the tendency to develop hypoglycemia and ketoacidosis. modern approach to type 1 dm management, especially in adolescents, includes the need for mandatory self-monitoring of blood glucose (BG). Adolescents with type 1 dm are unable to achieve target glucose levels themselves at home without BG monitoring. Glycemic control in type 1 dm should be accurate, simple and convenient, allowing patients to adjust insulin therapy for dm on their own. Selection of BG monitor is one of the main aspects of self-monitoring of BG. From the doctor's point of view, compliance with accuracy standards is the most important criterion for choosing the glucose meter, while from the patient’s perspective it is convenience and ease of use. With improvements in technology, the accuracy of BG measurement increases, the self-monitoring of BG procedure gets simpler, which results in higher adherence to treatment and treatment efficacy. It is impossible to achieve and maintain target BG levels without active full-fledged participation of patient with type 1 dm, self-monitoring of BG using the advanced, accurate and convenient for patient glucose meter, such as contour Plus one.
Issues of breast cancer diagnosis
Authors:   Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Litvyakova Elena V. , Belyakova A.S. ,   Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Denisov Maksim S. ,   Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Lun'kova Mariya N. ,   Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Zharikova I.A. ,   Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ivanov S.A. ,   Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center,   National Medical Research Radiological Center, Kaprin A.D. ,   Patrice Lumumba People’s Friendship University of Russia,   Herzen Moscow Research Oncological Institute – branch of the National Medical Research Radiological Center,, Kiseleva Marina V. ,   Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center
Published: June 2024

Today, most of patients with malignant neoplasms are patients with breast cancer, BC (18.3% of all malignant neoplasms). The increase in the diagnosis rate of stage I–II BC is observed since 2011: this indicator was 65% in 2011 and 72.5% in 2021. Screening that is currently related to secondary prevention of BC makes it possible to detect the disease in the preclinical phase, thereby increasing the possibility of recovery.
A clinical case of cardioprotective therapy with exogenous phosphocreatine during chemotherapy and anti HER2-neu therapy in a patient with breast cancer
Authors:   Center for Innovative Medical Technologies, Pylev Andrey L. , Lisovoy Vyacheslav A. ,   Multidisciplinary Clinic "SOYUZ", Kozlova Olga S. ,   Center for Innovative Medical Technologies
Published: June 2024

The authors describe a clinical observation of cardiotoxicity of anticancer targeted therapy in a young patient with HER2neu-positive breast cancer. The results of instrumental examinations demonstrating manifestations of cardiotoxicity are presented. The development of cardiovascular side effects against the background of anticancer treatment requires the appointment of cardioprotective therapy. Exogenous phosphocreatine (Neoton) can be considered as a cardioprotective agent, demonstrating efficacy in reversing cardiotoxicity induced by anti-HER2neu therapy.
Risk factors of rectocele in women of child-bearing age.
Authors:   Patrice Lumumba Peoples' Friendship University of Russia, Orazov Mekan R. , Mikhaleva Lyudmila M. ,   Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery, Krestinin Michael V. ,   Patrice Lumumba Peoples' Friendship University of Russia, Soiunov Mukhammednazar A. ,   Patrice Lumumba Peoples' Friendship University of Russia
Published: June 2024

This article systematically analyses the data available in the current literature regarding the patterns of vaginal wall prolapse with rectocele for-mation. Pelvic floor insufficiency currently occupies one of the leading positions in the structure of gynaecological diseases. However, recent stud-ies do not provide a clear answer on the role of individual risk factors and their combinations in the development of pelvic organ prolapse with rectocele formation.
Hyaluronic acid fillers safeguarding women’s health
Authors:   Patrice Lumumba Peoples' Friendship University of Russia, Orazov Mekan R. , Radzinskii Viktor E. ,   Patrice Lumumba Peoples' Friendship University of Russia, Dolgov Evgenii D. ,   Patrice Lumumba Peoples' Friendship University of Russia
Published: June 2024

Today, pelvic floor dysfunction (PFD) is one of the most pressing issues of modern gynecology. In patients with no macroscopic defects of the pelvic floor myofascial compartment, vaginal relaxation syndrome (VRS) that is highly prevalent among sexually active patients of child-bearing age represents the major PFD phenotype. Pregnancy and vaginal delivery constitute one of the most important etiological factors of VRS deter-mining high prevalence of the disorder. Furthermore, PFD results from the age-induced hypoestrogenism observed in peri- and postmenopausal patients. In such cases VRS and gaping vaginal opening may occur as early precursors of PFD. Based on the foregoing, it is important to consider the intimate contouring surgery as one of the most accessible and effective VRS correction methods for pelvic health restoration, improvement of the quality of life in general and sexual function in particular.
The course and outcomes of the gestational period and childbirth in women with pregravid overweight. Clinical analysis
Authors:   Far Eastern State Medical University, Pestrikova Tatyana Yu. , Knyazeva Tatyana P. ,   Far Eastern State Medical University, Yurasova Elena A. ,   Far Eastern State Medical University, Vladimirtseva Tatyana O. ,   Maternity Hospital №4, Khabarovsk
Published: June 2024

Aim. To study the results of the course and outcomes of the gestational period and childbirth in women with pregravid overweight, depending on the weight gain during pregnancy. Materials and methods. Using the continuous sampling method, we con-ducted a retrospective study of the results of pregnancy and childbirth in 291 women with initially pregravid excess body weight. The influence of the overall weight gain during the gestation period was assessed in 23 parameters reflecting the complications of pregnancy and childbirth. Results. The determination of the relative risk showed no positive relationship between the indicators characterizing the complications of the gestational period (gestational arterial hypertension, gestational diabetes mellitus) and childbirth in women with the recommended weight gain during pregnancy, with similar data in the group of women with reduced and increased body weight gain. Conclusion. Further studies are needed to study in more detail the observed relationships and predict risk factors for the occurrence of meta-bolically associated complications of the gestational period and childbirth in women with excessive pregravid body weight.
he relationship between preeclampsia and periodontal pathology
Authors:   Omsk State Medical University, Trukhan Dmitry I. , Sulimov Anatoly F. ,   Omsk State Medical University, Trukhan Larisa Yu. ,   Omsk State Medical University
Published: June 2024

Preeclampsia is a pregnancy-specific hypertension associated with systemic multiple organ damage that remains the leading cause of maternal and infant mortality worldwide. Chronic inflammatory diseases of the periodontium (gingivitis, periodontitis) occupy the 2nd place after caries in terms of prevalence among dental diseases. Periodontal pathology in the domestic literature is not currently considered as a risk factor for the development of preeclampsia. The present review considers clinical studies and reviews presented in the PubMed information base, which discuss the relationship between preeclampsia and periodontal disease. Based on the analysis of clinical studies, reviews and meta-analyses, a bidirec-tional relationship between preeclampsia and periodontal disease can be assumed. The main possible mechanisms of the relationship between preeclampsia and periodontal pathology are considered. The data presented in the review certainly require comprehension by both dentists and obstetricians-gynecologists and internists. But they clearly indicate the need to identify and actively treat dental diseases even at the stage of pre-conception preparation, as well as during pregnancy.
Original article Clinical significance of determining sST2 in the blood of patients with cardiac sarcoidosis
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Lebedeva Marina V. , Strizhakov Leonid A. ,   Sechenov First Moscow State Medical University (Sechenov University),   Scientific Research Institute of Occupational Medicine named after Academician N.F. Izmerov,   Lomonosov Moscow State University, Beketov Vladimir D. ,   Sechenov First Moscow State Medical University (Sechenov University), Taranova Marina V. ,   Sechenov First Moscow State Medical University (Sechenov University)
Published: June 2024

The results of a pilot study of the serum marker of cardiac damage sST2 in patients with chronic generalized sarcoidosis are presented. Correlations between the activity of sarcoidosis, sST2 levels and the risk of developing heart failure have been demonstrated.
Clinical Case Therapeutic consultation a patient with damage to the oral mucosa from the dentist. When, why, about what?
Authors:   Omsk State Medical University, Temnikova Elena A. , Chekina Anna V. ,   Omsk State Medical University, Vetkova Kira V. ,   Omsk State Medical University
Published: June 2024

Oral mucosal pathology is a significant problem in stomatology due to the complexity of a differential diagnosis and often requires the systemic therapy of it. Therefore, it is not uncommon for patients with diseases of the oral mucosa to be referred to a therapeutic physician to find the etiological factor of oral mucosa disease and to choose the systemic therapy. However, the purpose of the consultation and the capacity of the therapist’s physician in such situations may be interpreted differently by stomatologists and therapists. There is an example of the patient with lichen planus. The main tasks of the therapist consultation in this case are: to provide a general clinical examination of the possible somatic manifestations of the lichen planus autoimmune process, to evaluate the therapy to exclude possible influence some of the medication to the lesion of oral mucosal or progression lichen planus, to assess the general condition of the patient in order to select the treatment regimens using systemic corticosteroids and risk factors for the development of side effects of this therapy.
Pathogenetic aspects of recurrent endometrial hyperplasia without atypia in women of childbearing age
Authors:   Patrice Lumumba People’s Friendship University of Russi, Orazov Mekan R. , Mikhaleva Liudmila M. ,   Research Institute of Human Morphology named after Academician A.P. Avtsyna, Khamoshina Marina B. ,   Patrice Lumumba People’s Friendship University of Russi, Mullina Irina A. ,   Patrice Lumumba People’s Friendship University of Russi, Artemenko Yulia S. ,   Patrice Lumumba People’s Friendship University of Russi
Published: June 2024

Aim: to determine the most informative immunohistochemical markers of recurrent endometrial hyperplasia without atypia in women of childbearing age. Methods. Prospective analysis of 89 patients of childbearing age was performed at the Department of Obstetrics and Gynecology with Perinatology, Medical Institute of the Peoples' Friendship University of Russia. During the study the patients were divided into two cohorts based on the EH course: the index group (n=45) was represented by patients with the morphologically verified recurrent endometrial hyperplasia without atypia (one or more episodes within a year), the control group (n=44) was represented by patients with the newly diagnosed endometrial hyperplasia without atypia. The average age of patients in the studied cohort was 44±3.0 years (comparison group – 42±2.0 years). Results. Immunohistochemical markers of recurrence were identified during the study: high Ki-67 expression (p<0.05), low Bcl-2 expression (p<0.05) that enhanced proliferative and reduce antiproliferative processes in the endometrium. Immunohistochemical signs of chronic endometritis (СD138+) were found in 40% of patients suffering from recurrent endometrial hyperplasia (in 18.2% of controls). It should be also noted that there was local hyperestrogenism associated with high expression of estrogen in the glandular epithelium and stroma. Conclusion. Thus, the Ki-67 marker expression and low Bcl-2 expression contribute to recurrence of endometrial hyperplasia without atypia. Furthermore, the combination of endometrial hyperplasia and morphologically verified chronic endometritis provides a further predictor of the endometrial proliferative process recurrence. Immunohistochemistry makes it possible to predict not only the risk of recurrent endometrial hyperplasia, but also the disease course. However, there is currently no universal marker allowing one to predict the chance of hyperplasia diagnosis and recurrence. Design: a comparative prospective study.
Clinical analysis of cases of precancer of the oral mucosa and the red border of the lip
Authors:   Belarusian State Medical University, Lutskaya Irina K.
Published: June 2024

Early detection of diseases prone to malignancy is one of the most important problems in medicine. Elements of lesions on the mucous membrane of the oral cavity and the red border of the lips, characterized by a risk of degeneration, are available for visual inspection and can be detected during a general examination of the patient by a doctor of any specialty. A qualified description of clinical cases helps to familiarize specialists working in healthcare institutions with the clinical manifestations of pathology.
Drug safety: focus on long-term therapy with proton pump inhibitors. Possible side effects
Authors:   Omsk State Medical University, Trukhan Dmitry I.
Published: June 2024

Proton pump inhibitors (PPIs) are the most effective drugs for the treatment of acid-related diseases. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note that when prescribing PPIs in large doses for a long period, the possibility of side effects should be taken into account. In a clinical context, a reasonable definition of long-term PPI use would be PPI use for more than 8 weeks in patients with symptoms of gastroesophageal reflux disease and more than 4 weeks in patients with peptic ulcers or functional dyspepsia. There are no reviews in the domestic literature on the safety of PPIs during long-term use. In this regard, a search was conducted in the PubMed and Scopus information databases for publications on the safety of PPI use, including sources up to November 15, 2023, which showed that long-term use of PPIs is associated with the possible development of numerous side effects. The first publication examined the possible side effects of long-term use of PPIs: the development of infections, an increased risk of fractures and kidney pathology. This review examines the most possible side effects associated with long-term PPI therapy: the development of cancer and electrolyte disturbances. If there are indications for long-term use of PPIs in accordance with clinical guidelines (Barrett's esophagus, erosive esophagitis C/D and a number of others), oncological vigilance should be exercised and monitoring aimed at identifying electrolyte disturbances should be carried out.
The course of headache after the end of treatment with erenumab in patients with episodic and chronic migraine
Authors:   Polyclinic no. 1, department of the President of the Russian Federation, Garmanova Anna A. , Berdnikova Anna V. ,   Alexander Vein Headache clinic,   I.m. Sechenov First moscow State medical university (Sechenov university), Latysheva Nina V. ,   Alexander Vein Headache clinic,   I.m. Sechenov First moscow State medical university (Sechenov university)
Published: June 2024

Background. Migraine is the second most incapacitating disease and is accompanied by multiple comorbidities, especially in chronic migraines. Migraine treatment and improvement of the patients’ quality of life are an important clinical issue. The calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) are the first target therapy for migraine. To date, there are no published data on the duration of effect after using mAbs. Aim. To determine the effect duration after cessation of erenumab treatment in patients with migraine. Methods. The study included 64 patients with migraine, who received at least three doses of erenumab; treatment was stopped when reduction of the headache frequency by at least 30% was achieved. The frequency of headache and migraine were assessed 1, 3 and 6 months after the end of treatment. Results. There was a significant increase in the frequency of headache compared to the values reported at the end of treatment, however, the rates were still significantly lower compared to the baseline values. In some patients, no increase in headache frequency following discontinuation of treatment was observed.
Cervicalgia in patients with migraine – a comorbid nosology or a clinical aspect of central sensitization?
Authors:   Kazan State Medical University, Khairutdinova Olga S. , Bogdanov Enver I. ,   Kazan State Medical University
Published: June 2024

Relevance. The phenomenon of central sensitization occurs when physiological activity in nociceptive pathways increases and leads to abnormal sensitivity; it is defined as “increased sensitivity of nociceptive neurons of the central nervous system to their normal or subthreshold afferent input,” according to the definition provided by the International Association for the Study of Pain (IASP). The excitability of spinal cord neurons significantly modifies the gain of the somatosensory system. Chronic pain syndromes, anxiety-depressive disorder, sleep disorders are currently very common in the population, significantly reducing the quality of life of the population; the pathogenesis of these nosologies lies in central sensitization. Objective. To study the clinical manifestations of central sensitization in patients with episodic migraine associated with neck pain or cervicogenic headache. Materials and methods. The longitudinal prospective study included 180 patients, divided into 3 groups: 1) patients with a combination of migraine and cervicogenic headache – 60 people (study group); 2) patients with a combination of migraine and cervicalgia diagnoses – 60 people (control group); 3) patients diagnosed with migraine without complaints of pain and limitation of movements in the cervical spine – 60 people (additional group). Results. In patients with migraine and comorbid cervical headache, more pronounced central sensitization was revealed when compared with comorbid cervicalgia. Myofascial pain syndrome involving the trapezius and temporal muscles can resolve on its own with specific migraine therapy with monoclonal antibodies, however, to relieve tension and soreness in the masseter and inferior oblique muscles, the addition of therapeutic exercises and gentle manual techniques is more effective. Taking into account the identified direct relationships of moderate strength between the number of painful points of exit of the trigeminal nerve, the muscles of the pericranial region involved, as well as the effect of treatment of migraine attacks with monoclonal antibodies, it can be concluded that central sensitization is more pronounced when the masseter and inferior oblique muscles are involved. Conclusions. During examination of patients with migraine with comorbid active cervicalgic factor or even if it is absence, it is necessary to make a thorough examination of the facial and cranioverebral region muscles, even in the absence of patient complaints of pain in the face or neck, and also prescribe specific therapeutic exercises to increase the effectiveness of treatment. In all patients with migraine, regardless of chronicity, it is necessary to assess the intensity of central sensitization for timely and more complete provision of medical care.
The Role of Complement System’s C3 and C4 Fractions in the Pathogenesis of Herpetic Uveitis
Authors:   Yerevan State Medical University, Kambulyan Lusine V. , Chopikyan Armine S. ,   Yerevan State Medical University, Iritsyan Sevan Z. ,   Yerevan Medical Scientific Center, Hovakimyan Anna V. ,   Yerevan State Medical University,   Ophthalmological Center after S.V. Malayan
Published: June 2024

Herpetic anterior uveitis is mainly considered as acute unilateral anterior uveitis with non-granulomatous, granulomatous, or stellate keratic precipitates, which is associated with iris atrophy, decreased corneal sensation, and an acute rise in the intraocular pressure. The diagnosis of herpetic anterior uveitis usually is based on clinical findings. We presented several clinical cases with atypical manifestations. Our study aims to understand the role of the complement system’s C3 and C4 fractions in the pathogenesis of herpetic anterior uveitis.
Hermeneutik Açıdan Mevlevî Âyinleri
Authors: Kaptan Merve Nur
Published: June 2024

Sosyal bilimlerde iki temel paradigmadan söz edilmektedir. Bunlardan ilki açıklamaya yönelik düşüncede temellenen pozitivizm; diğeri ise poziti-vizme alternatif olarak ortaya çıkan anlayıcı/yorumlayıcı paradigmadır. Sosyo-kültürel manada birçok alanda kendine yer bulan bir anlam kuramı olarak hermeneutik yaklaşım anlamaya/yorumlamaya dayalı paradigmalar arasında yer almaktadır. Hermeneutik yaklaşım görünenin aksine görünmeyeni kavrayabilme noktasında karşımıza çıkmaktadır. Bu minvalde sosyo-kültürel açıdan Türk kültürünün bir parçası olarak Mevlevi ayinlerini hermeneutik bağlamda ele almak ayinlerin anlam dünyasını ortaya çıkarmak açısından önem arz etmektedir. Mevlevilik tarikatı tasavvuf düşüncesinde vahdet-i vücud esasına ve aynı zamanda ezoterik bir inanç sistemine dayanmaktadır. Bu manada bahsi geçen inanç sistemini yansıtan Mevlevilik ve Mevlevi ayinleri görünenin ötesinde anlamlar içermektedir. Özellikle musiki, ayinlerde ana unsur olarak öne çıkarak, doğrudan töreni yönlendirebilen bir niteliğe sahiptir. Bu doğrultuda ritüel esnasındaki icralar musiki ile başlamakta ve musiki ile yönetilerek ritüelin sürekliliği sağlanmaktadır. Dolayısıyla Mevlevilikte musiki vecde eşlik eden bir araç misyonu görmektedir. Mevlevi semaında yapılan her hareket, her uygulama ve merasimin ayrılmaz bir parçası olan Mevlevi ayinlerinin her aşaması, her olgusu ve her edimi içinde metaforik anlamlar barındırmaktadır. Bu çerçevede hermeneutik paradigmasının teolojik boyutu ile sınırlı olan araştırmada Mevlevi ayinlerinin manevi anlamları literatür çalışmasıyla tespit edilmiş, konu ile alakalı belgeler incelenmiş, elde edilen verilerin betimsel analizi yapılmış ve bulgular ortaya konulmuştur.
Relações sociedade-natureza a partir da teoria da alienação: contribuições teórico-conceituais de Marx e Lefebvre
Authors: Godinho Benedito Gustavo
Published: June 2024

A teoria da alienação desenvolvida por Marx é central para a construção de análises ontológicas e epistemológicas críticas acerca das relações sociedade-natureza na modernidade. Partindo desse pressuposto, objetiva-se estabelecer relações entre aspectos conceituais da teoria da alienação em Marx e sua atualização pelo filósofo Henri Lefebvre, propiciando, assim, interpretações da cisão sociedade-natureza a partir da dimensão espacial da realidade.
Maritime Security in a Technological Era: Addressing Challenges in Balancing Technology and Ethics
Authors: Islam Md Syful
Published: June 2024

Within the context of rapid technological advancements, the ethical dimensions of maritime security are explored, focusing on the challenges and opportunities brought about by emerging technologies and their implications for maritime security practices. Potential risks related to technology misuse, such as privacy infringement, disproportionate use of force, and the erosion of human judgment and accountability, are emphasized. The importance of adopting a balanced approach that considers both the benefits and risks of technological advancements is stressed, as well as the need for robust governance frameworks and international cooperation to ensure responsible and ethical technology use in maritime security. The research methodology involves a systematic literature review of scholarly articles, policy documents, and relevant case studies in the field of maritime security. Ethical frameworks, including proportionality, necessity, transparency, accountability, and human rights, are applied to assess the ethical implications of technologies like unmanned maritime systems, cyber threats, and surveillance capabilities. The significance of ethical training and education for maritime security personnel in promoting responsible and accountable decision-making is underscored, and the article proposes the inclusion of case studies and simulations as effective tools for examining the practical application and effectiveness of ethical training in real-world scenarios. By advocating for a proactive approach that balances technological opportunities with ethical principles, this article contributes to the ongoing discourse on maritime security ethics, providing valuable insights for policymakers, practitioners, and researchers in the field, and offering a roadmap for fostering a secure, transparent, and rights-respecting maritime domain.
Neutrophils, the major players in healing after myocardial infarction
Authors:   Victor Babeș National Institute of Pathology, Bucharest, Romania, Constantinescu Andrei , Valcu Claudia Adelina ,   Victor Babeș National Institute of Pathology, Bucharest, Romania, Tanca Antoanela ,   Victor Babeș National Institute of Pathology, Bucharest, Romania, Liehn Elisa ,   Institute for Molecular Medicine, University of Southern Denmark
Published: June 2024

Neutrophils are a type of immune cells with controversial functions. While their role in the protection against the microbial invasion is well known, the role in controlling and monitoring the non-infection healing processes of the injured tissue and organs are now to be discovered. Particularly in the healing after myocardial infarction, the neutrophils were considered for a long time the “bad guys”, sustaining the inflammation and interfering with the repair processes. However, all the attempt to deplete or massively inhibit their activity in experimental conditions or clinical settings lead to catastrophic results, with defective scar formation and worsening of the heart function. As recent studies pointed out the essential role of the neutrophils in monitoring and guiding all the processes involved in the proper tissular healing, a detailed investigation of mechanistic inside is required for a selective and effective design of therapeutical strategies targeting neutrophils to preserve and improve heart function after an acute myocardial infarction.
Effectiveness of Pricing Strategies on Consumer Perceptions in Qatar
Authors: Salem Rashid
Published: June 2024

Purpose: The aim of the study was to assess the effectiveness of pricing strategies on consumer perceptions in Qatar.
Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries.
Findings: The study found that pricing plays a significant role in shaping how consumers perceive products and brands. Dynamic pricing, for instance, where prices change based on demand or other factors, can influence consumer perceptions of value and fairness. Additionally, study indicates that using odd pricing (e.g., pricing products at $9.99 instead of $10) can create a perception of a better deal and increase purchase likelihood. Moreover, bundle pricing strategies, such as offering discounts for purchasing multiple items together, can lead to positive consumer perceptions of value and incentivize larger purchases. Overall, pricing strategies have a notable impact on consumer perceptions, affecting their attitudes, purchase intentions, and overall satisfaction with products and brands.
Implications to Theory, Practice and Policy: Perceived value theory, cognitive dissonance theory and brand equity theory may be used to anchor future studies on assessing the effectiveness of pricing strategies on consumer perceptions in Qatar. In practice, businesses can leverage insights from empirical studies to adopt a tailored approach to pricing strategies. From a policy perspective, regulatory guidelines should be established to ensure fairness, transparency, and consumer protection in pricing practices.
Majör Depresif Bozuklukta Gen-Çevre Etkileşimi
Authors: Şanal Güngör Beyza , Güngör Ali
Published: June 2024

Majör depresif bozukluk (MDB), ruhsal bozukluklar içerisinde tüm dünyada görülmekte olan yaygın, bireyi zaman içerisinde güçten düşüren bir duygudurum bozukluğudur. MDB etiyolojisinde genetik ve çevresel faktörler birlikte rol oynamaktadır. Bu çalışmanın amacı dünyada en önemli ruhsal bozukluklar arasında yer alan majör depresif bozukluğu gen-çevre etkileşimi açısından incelemektir. Araştırma kapsamında DergiPark, Google Akademik, PsycARTICLES, PubMed, TR Dizin ve Web of Science veri tabanlarında “majör depresif bozukluk”, “depresyon”, “epigenetik”, “depresyon ve epigenetik”, “depresyon ve genetik”, “depresyon ve çevre” anahtar sözcük kullanımı ile İngilizce ve Türkçe tam metin olarak ulaşılan makaleler gözden geçirilmiştir. Alanyazında yer alan gen-çevre etkileşim çalışmaları üzerinde durularak epigenetik mekanizmalar incelenmiştir. Genetik faktörlerin çevresel faktörlerle etkileşimi sonucunda meydana gelen klinik tablo çalışma kapsamında alanyazın ışığında tartışılmıştır. Buna göre, bozukluğun oluşumuna neden olan belirli tek bir genetik faktörden bahsedilememektedir. Olumsuz çevre yaşantılarının genetik ifade üzerinde güçlü etkileri bulunmakla birlikte, bireysel farklılıklar durumu önemli ölçüde değiştirebilmektedir. Bütüncül bir gen-çevre etkileşim modeli, genetik polimorfizmler ve DNA metilasyonu gibi epigenetik mekanizmalar ve çevresel etkiler arasındaki etkileşim mekanizmalarını içermelidir. Yapılan çalışmada majör depresif bozukluk ve gen-çevre etkileşimine genel bakış açısı sunmanın hastalığın doğasını doğru kavramada yardımcı olarak bireylerin yaşam kalitelerinin artmasına, hastalık yükünün azalması neticesinde maliyette ciddi tasarruflara ve morbidite ile mortaliteyi azaltmasına katkı sağlayacağı düşünülmektedir.
Роль нейроинтерфейсов в будущем
Authors: Шибаев В. М. , Зуев М. А. , Баланев К. С.
Published: June 2024

Статья посвящена рассмотрению технологий нейроинтерфейсов (BCI) и их значению в современном мире. Нейроинтерфейсы, позволяющие прямое взаимодействие между мозгом и компьютером, открывают новые возможности в медицине, игровой индустрии и повседневной жизни. В статье обсуждаются принципы работы BCI, примеры их применения, а также перспективы и возможные направления развития этой инновационной технологии.
The Effects of Brain-based Learning Strategies on Low Ability Malaysian English as a Second Language Learners’ Writing Performance
Authors: Wilson Albert , Ramanair Joseph , Rethinasamy Souba
Published: June 2024

The main goal of Brain-based Learning (BBL) is to create effective learning conditions that allow the brain to naturally learn. A plethora of studies on BBL learner performance and perceptions have been conducted in a variety of contexts. However, BBL studies on low-ability ESL learners are still in their infancy. Therefore, this study investigated low-ability ESL Malaysian learners’ BBL performance and perceptions in the classroom. A purposive sampling technique is used to collect quantitative data from 150 learners. A quasi-experimental design compares the learners’ pretest and post-test scores. The descriptive analysis indicated a favorable outcome when the post-test mean score was higher than the pretest scores in the literature critical response writing test. A pair sample t-test was also conducted, and results showed that there is a statistically significant improvement in the scores from the pretest (M = 2.45, SD = 1.50) to the post-test (M = 5.35, SD = 2.40), t(149) = -15.48, p<.05. A qualitative design is also used to investigate three learner-focus groups’ (five in each group) responses after BBL intervention. Findings revealed that there are generally positive responses related to the BBL theoretical framework of this study. However, there are some negative responses pertaining to two components of the framework. This study indicates that BBL can enhance low-ability ESL learners’ writing performance and active learning engagement.
Data-Segmentation Verification and a Target Generative Adversarial Network: EEG-Based Emotion Recognition
Authors: Yin Lufeng , Li Yong
Published: June 2024

Emotion recognition is a crucial component of artificial intelligence. As one of the main factors in emotion recognition, data-driven affective computing heavily relies on high-quality training data, which may not always be readily available due to various reasons. Addressing the challenge of data augmentation with inter-class and intra-class imbalances in emotion-evoking data is a critical issue in affective computing. Currently, many researches have addressed the problem of inter-class imbalance, in which data segmentation processing methods are widely used. However, the rationality of data segmentation methods needs to be verified; meanwhile, the solution to the intra-class imbalance problem remains to be solved. In this paper, we validate the rationality of data segmentation methods through experiments and propose a targeted data generation mechanism. This mechanism intentionally generates pseudo samples in proximity to the oftenoverlooked samples, aimed at mitigating intra-class imbalance. Combined with Wasserstein generative adversarial network-gradient penalty and generative adversarial network-based self-supervised, we have got T-WGAN-GP and T-GANSER. We then apply these approaches to the DEAP dataset for emotion recognition with different data segmentation methods, including segmenting the data after (MI) or before (MII) the division of the training and testing sets, as well as no data segmentation at all (MIII). Results show that MII and MIII in the segmentation method are theoretically sound, and T-WGAN-GP obtains the best accuracy in the reasonable segmentation method due to its targeted data generation mechanism. This mechanism effectively mitigates the intra-class imbalance to some extent.
Cervical Tuberculosis Mimicking Tumor Persistence: A Case Report
Authors: Factor, MD Patricia Ann A. , Toral, MD, MSc Jean Anne B. , Bravo, MD, MS Sybill Lizanne R.
Published: June 2024

Tuberculosis can coexist with malignancy in the same organ, but cancer with TB in the cervix is rare. This is a case of cervical tuberculosis diagnosed in a cervical cancer patient after concurrent chemoradiotherapy and brachytherapy.
This is the case of a 38-year-old G2P2 (2002) diagnosed with squamous cell carcinoma, large cell non-keratinizing cervix, Stage IIIB. The patient underwent concurrent chemoradiotherapy and brachytherapy.
One month after the last brachytherapy dose, the attending physician noted a nodularity on the anterior lip of the cervix. A cervical punch biopsy was done to rule out tumor persistence. The histopathology revealed chronic granulomatous inflammation with Langhan’s type multinucleated giant cells consistent with tuberculous infection.
She was diagnosed with cervical tuberculosis, postulated to be from latent TB reactivation, and was given Anti-Koch’s medication for six months. After receiving Anti-Koch’s treatment, the cervical nodularity was no longer appreciated, and the rest of the cervix was smooth on palpation. Her Pap Test was negative for any intraepithelial lesion and was declared with no evidence of carcinoma.
A possible latent TB infection should always be screened in cancer patients from high-burden areas or those with close contact treated for tuberculosis because immunosuppression during cancer treatment can cause the reactivation of tuberculous disease.
Cervical tuberculosis complicating cervical malignancy is treatable with Anti-Koch’s therapy and has not been shown to affect the course of the carcinoma.
Desafios e resistências em gênero e sexualidade no Brasil contemporâneo
Authors: Almeida Heloisa Buarque de , Henning Carlos Eduardo
Published: June 2024

Esta coletânea é um dos resultados dos trabalhos realizados pelo Comitê de Gênero e Sexualidade da Associação Brasileira de Antropologia (ABA) no biênio 2019-2020 sob a coordenação de Heloisa Buarque de Almeida (USP) e vice-coordenação de Carlos Eduardo Henning (UFG). Parte de seus capítulos são desdobramentos do Simpósio Especial “Desafios e Resistências no campo de Gênero e Sexualidade no Brasil Contemporâneo” , na 32ª RBA, em 2020. Por um lado, buscamos reunir textos que fazem análises “quentes” da conjuntura política daquele momento, após a eleição de Bolsonaro, e assim mantivemos o título acerca de “desafios e resistências”. Assim, sabíamos de colegas que estavam refletindo sobre movimentos como “Escola sem Partido” e as propostas no Plano Nacional de Educação em casas legislativas estaduais e municipais de retirar totalmente o termo “gênero” das políticas públicas. Esta chave temática se materializou na primeira parte da chamada de capítulos aqui reunidos. Por outro lado, convidamos colegas que trouxessem também um panorama da diversidade de pesquisas e abordagens antropológicas sobre gênero e sexualidade no Brasil, com foco especificamente nas investigações com abordagens interseccionais, atentas aos atravessamentos dos marcadores sociais da diferença. A ideia era mostrar a qualidade e densidade das pesquisas como parte de nossa tarefa de resistência no campo científico: a despeito de todos os ataques, continuaremos a falar em gênero e sexualidade! Mantivemos a postura da ABA de defesa dos direitos humanos ao permitir uma ciência com posturas políticas explícitas em favor dos direitos dos grupos minoritários, como mulheres, pessoas LGBTQIA+, pessoas racializadas, entre outros.
Masculinidades negras e antinegritude
Authors: Pinho Osmundo
Published: June 2024

Nos últimos anos o debate sobre masculinidades de um modo em geral, e sobre masculinidades racializadas, em particular, tem ultrapassado os limites da bolha acadêmica e ativista, ganhando espaço em campanhas de governo e na esfera pública mediatizada. Tal expansão ocorre contra um pano de fundo de longa duração que criminaliza e demoniza homens negros, sob diversas modalidades de representação, imagens-controle, e políticas estatais anti-negro. Neste ensaio apresento uma reconstituição tentativa da formação do campo de estudos de masculinidades negras; aponto para uma contradição, ou estrutura de sentimento antinegra, definida também como uma “rito de passagem” para a masculinidade negra, a relação com a “mulher branca, para ressaltar como esta estrutura de dupla face significa a um só tempo a construção da masculinidade/heterossexualidade e da negritude no mundo antinegro; por fim, resumo algumas abordagens etnográficas que ressaltam a dimensão sociológica da antinegritude como condição para a experiência vivida de homens negros na periferia colonial do capitalismo racializado.
Alguns vetores e tensões das disputas “antigênero” no cenário internacional e brasileiro
Authors: Rohden Fabíola
Published: June 2024

Este capítulo tem o objetivo de discutir como as dimensões de gênero e sexualidade têm se conformado em um idioma político cada vez mais importante nas últimas décadas, tendo como ponto de partida os ataques à igualdade de gênero, à diversidade sexual e aos direitos sexuais e reprodutivos e articulados em torno da promoção da categoria “ideologia de gênero”.