bluuebunny/crossref_metadata_2025 huggingface dataset:
Home dialysis : what are the barriers . A French nephrologist survey
Authors: Geneviève Magalie , Bataille Stanislas , Beaume Julie , Hocine Aldjia , De Laforcade Louis , Garnier Anne-Sophie , Bureau Come , Brunner Flora , Braconnier Antoine , Seret Guilllaume
Published: November 2020

Home dialysis, which includes Peritoneal Dialysis and Home Hemodialysis, provides lots of profit to patients suffering of Chronic Kidney Disease, especially in terms of comfort, life quality and autonomy. However, its use is marginal in France, with an inhomogenous distributaion according to geographical regions. We conducted a French national survey of nephrologists to assess the barriers to the development of home dialysis. After analyzing the responses of the 230 participating nephrologists, the main obstacles to the development of the two techniques were identified and classified according to their reporting rate. The major obstacles that emerge from the survey are : the lack of information among the general public, a lack of acknowledgement of nurses specializing in these techniques, the limited number of structures that practice dialysis at home, and information difficulties among patient about dialysis techniques. The specific peritoneal dialysis-related difficulties reported are : difficulties in management of follow-up care and rehabilitation, the fear of insufficient purification and the difficulties related to the dialysis catheter. Concerning home hemodialysis, the barriers concern fear of autopunction and the need for a third party. This study helps to identify the representations of nephrologists on the major obstacles to the development of home dialysis to develop lines of thought for its promotion, both in terms of training, institutional acknowledgement, and the necessary regulatory evolution.
Créer et maintenir un accès péritonéal optimal chez les patients adultes : mise à jour 2019
Authors: Dratwa Max , Verger Christian
Published: November 2020

En avril 2019 la Société Internationale de Dialyse Péritonéale a publié en "open access" ses dernières recommandations pour créer et maintenir un abord péritonéal optimal chez les patients adultes. Ces recommandations sont un guide important pour les équipes médicales, infirmières et chirurgicales de tous les pays. Afin d'assurer la meilleure diffusion possible auprès des francophones qui se sentent plus à l'aise avec un texte dans leur langue maternelle, le Registre de Dialyse Péritonéale de Langue Française a assuré la traduction de ce texte. Pour toute référence dans une publication, il est indispensable que seul le texte original qui soit cité :ISPD Guidelines/recommendationsCreating and maintaining optimal peritoneal dialysis access in the adult patient : 2019 update.John H. Crabtree et al. Peritoneal Dialysis International. https://doi.org/10.3747/pdi.2018.00232Au nom de la communauté néphrologique francophone nous remercions chaleureusement l'ISPD de nous avoir accordé l'autorisation de réaliser cette traduction.

Cette traduction adhère au copyright de la version originale anglaise.

Ce(tte) œuvre est mise à disposition selon les termes de la Licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.
A Nurse mailing list serving the Dialysis at Home community
Authors: PADERNOZ Marie
Published: November 2020

Aware of the difficulties encountered by the centers in the outpatient management of peritoneal dialysis patients, on March 21, 2016, the French Language Peritoneal Dialysis Registry (RDPLF) launched an «alloDP» nursing list for the benefit of Home Dialysis units active in the Registry. Difficulties in relation to the isolation of the teams, the size of the centers, the number of participants, the lack of knowledge in the technique are undeniably a hindrance to the development of home treatment.

This mailing list is exclusively reserved for home dialysis nurses after registration by the RDPLF. They need an email address, if possible, personal. Nephrologists and nurses at the material supply commercial providers may have access to alloDP, upon request, but only as «readers».

To break her isolation, or sense of isolation, the nurse simply sends her question, request, or need to the nursing community to the address allodp@rdplf.org. The wealth of sharing does the rest.

To illustrate the content of the exchanges, we have chosen to summarize six of them in this article.
Peritoneal catheter infections : data from the French language peritoneal dialysis registry (RDPLF), risk factors
Authors: Vernier Isabelle , Fabre Emmanuel , Dratwa Max , Verger Christian
Published: November 2020

Peritoneal catheter infections : data from the French language peritoneal dialysis registry (RDPLF), risk factors

The French Language Peritoneal Dialysis Registry (RDPLF) record since 1997 all data dealing with peritoneal catheter insertion and follow up.

The aim of this study is to analyze catheter infections on 10801 catheters in 144 centres from January 1, 1997 and December 31, 2018.

Infections are more common in the first month and 50% occur before the tenth month. The risk of infection increases in case of wall hematoma, initial fluid leakage, and obesity. It decreases with the use of prophylactic antibiotics at the time of catheter insertion, with experienced operator, if the first dressing is delayed for 7 days, and with mupirocin as exit-site prophylaxis.

During last two decades the percentage of Staphylococcus aureus infections has decreased, whereas the proportion of Pseudomonas, Corynebacterium and other Gram + cocci increased.

The incidence of catheter infections is low compared to literature data: it decreased to 0.16 episodes per year for the 2013-2017 period.

Adherence to ISPD guidelines: preoperative antibioprophylaxis is the most followed guideline (70.7% of catheter implantations in 2018). Local antibioprophylaxis concerns only 15.6% of catheters, and remains concentrated in a few centres ; mupirocin is the most frequently used agent. Screening for nasal carriage of S. aureus is performed in only 42% of cases.

The catheter section of the RDPLF has allowed the follow-up of clinical practices incidence of infections and ecology for 21 years, both at the national and center level Our study confirms a wide variability in clinical practices, compared to ISPD guidelines.
Hyponatremia in peritoneal dialysis : free water overload, hyperosmolarity or malnutrition ?
Authors: De Arteaga Javier
Published: November 2020

Hyponatremia is one of the most common electrolyte abnormalities in clinical practice and is associated with higher morbidity and mortality. On dialysis, hyponatremia is also quite common: 6 to 29% of hemodialysis patients and 11 to 26% of peritoneal dialysis (PD) patients have a serum ≤ 135mmol / L.Hyponatremia in PD has unique aspects that confer different clinical consequences and treatment needs compared to subjects with normal kidney function.The specificities of PD are mainly related to an ultrafiltrate quality, both in terms of sodium extraction and free water transfer, different according to the osmotic agent used in the dialysate (crystalloid or colloid osmotic agent) and according to the characteristics of the peritoneal membrane (functionality of aquaporins, preservation of osmotic conductance to glucose ...).In the short or medium term, loss of residual renal function is highly correlated with the appearance of hyponatremia.Finally, undernutrition, a frequent situation in dialysis and often associated with hypokalemia, can also be a cause of hyponatremia.The purpose of this article is to help understand the pathophysiology of hyponatremia in PD, which is of paramount importance to ensure appropriate treatment.
Efficiency and safety of using a peritoneal dialysis catheter weighted with a stainless steel ballast : the Limousin experience
Authors: Larivière-Durgueil Bénédicte , Boudet Rémi , Essig Marie , Bouvier Stéphane , Abdeh Ali , Beauchamp Christine , Ciobotaru Monica
Published: November 2020

Objective: To assess the recurrence of PD catheter migration after the introduction of a walnut ballast. Materials and Methods: Retrospective study from 1999 to 2014 of PD patients followed in Limousin. Were compared two groups: ballast group (patients who benefited from the establishment of stainless steel ballast at the intraperitoneal catheter extremity) with 26 patients and control group with 204 patients. The primary endpoint was the occurrence of an episode catheter’s migration after ballast’s establishment. Secondary objectives were (i) to determine the causal factors leading to the catheter weighting, (ii) to ensure the safety of the procedure on the following criteria: infectious complications, mechanicals complications, epurations criteria, and catheter’s survival. Results: More than one year after the implementation of the ballast, no recurrent migration was observed in 86.6% of cases. It wasn’t found an increased risk of infections (OR = 0.5, 95% CI [0.22, 1.13]) or mechanical complications (OR = 1.77- 95% CI [0.77, 4.05]) between the two groups. The adequation criteria were similar: KT / V total : 2.37 in the control group and 2.28 in the ballast group (p = 0.63). The survival of the ballast catheter was comparable among the two groups (p = 0.983). Three causal factors that led to the ballast were identified: automated peritoneal dialysis (APD) (OR = 0.38, 95% CI [0.16, 0.9]), the failure from the first use of the catheter (OR = 19.48, CI 95 % [7.67, 49.48]) and the incarceration of the omentum (OR = 15.84, 95% CI [5.81, 43.21]). Conclusion: The ballast used in these study appears to prevent recurrence of migration, without any impact in terms of infectious or mechanical complications, or on the dialysis criteria or on catheter’s survival. However this catheter does currently not have an EC authorization
Revue de presse club des jeunes néphrologues (CJN) : 4e trimestre 2019 de la Dialyse à Domicile
Authors: Morinière Beaume Julie , Nodimar Céline , Seret Guillaume , Vrigneaud Laurence , Bataille Stanislas , Carceles Odette , Gosselin Morgane , Lavainne Frederic
Published: November 2020

Introduction (NDLR)

Un groupe de néphrologues issus du Club des jeunes Néphrologues sélectionne chaque mois à tour de rôle un article de la littérature internationale en rapport avec la dialyse à domicile, Dialyse Péritonéale ou Hémodialyse à Domicile, et en propose un résumé en français et son analyse. Ces résumés sont librement téléchargeables sur le site du RDPLF à l’adresse : https://www.rdplf.org/biblio.html. A partir de décembre 2018 ceux sélectionnés au cours du trimestre par ces néphrologues sont publiés sous leur nom dans la présente rubrique du Bulletin de la Dialyse à Domicile.
Peritoneal Dialysis at Ibn Sina Hospital in Rabat: 10 years’ experience
Authors: Benbella Meryem , Guennoun Aziza , Belrhiti Mohamed , Bouattar Tarik , Bayahia Rabia , Ouzeddoun Naima , Benamar Loubna
Published: November 2020

Introduction: 

The choice of dialysis modality has become an important decision that affects not only the country's health policy in the management of chronic end stage renal failure, but also the quality of life of patients and their survival. Peritoneal dialysis is an alternative for the treatment of these patients. The objective of our work is to report the epidemiological, clinical and biological results in the unit of PD, UHC of Rabat and to clarify the obstacles to the development of PD in Morocco. 

Material and Methods: 

We conducted a descriptive retrospective study in our PD unit from July 2006 to July 2017, including all patients who were in PD by choice or necessity and enrolled in the French Peritoneal Dialysis Registry (RDPLF). 

Results: In 10 years, 159 patients were placed in PD, with an average age of 50.44 +/- 17.42 years and a sex ratio of 1.36. The indication for placement of setting in PD was by choice in 34% of the cases, social in 52% and medical in 14% of cases. Mechanical complications were dominated by catheter migrations. Infectious complications were represented by peritonitis, caused by poor of hygiene in 42% of cases.

Conclusion: The obstacles to the development of PD are the lack of knowledge of the technique by the patients, as well as the prejudices or myths about the technique.
Recommandations de pratique de la Société internationale de dialyse péritonéale: prescrire une dialyse péritonéale de haute qualité dirigée par un objectif
Authors: Dratwa Max , Verger Christian
Published: November 2020

En Janvier 2020 la Société Internationale de Dialyse Péritonéale a publié en "open access" ses dernières recommandations pour prescrire une dialyse péritonéale de haute qualité dirigée par un objectif . Ces recommandations sont un guide important pour les équipes médicales, infirmières de tous les pays.  Elles sont d'emblée traduite en pluiseurs langus afin d'assurer la meilleure diffusion possible. Comme lors de précédents récommandations  le Registre de Dialyse Péritonéale de Langue Française  (RDPLF) a assuré la traduction de ce texte. Pour toute référence dans une publication, il est indispensable que seul le texte original soit cité :International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysisEdwina A Brown, Peter G Blake, Neil Boudville et al.

https://journals.sagepub.com/doi/10.1177/0896860819895364Au nom de la communauté néphrologique francophone nous remercions chaleureusement l'ISPD de nous avoir accordé l'autorisation de réaliser cette traduction.

Cette traduction adhère au copyright de la version originale anglaise.

Ce(tte) œuvre est mise à disposition selon les termes de la Licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.
Peritoneal dialysis in a Moroccan center: Prevalence and complications
Authors: Bahadi Abdelaali , Benbria Sanaa , Rafik Hicham , El Kabbaj Driss
Published: November 2020

Abstract :

Introduction: Peritoneal dialysis (PD) is as effective as hemodialysis and often provides a better quality of life for patients. Despite this, the replacement therapy remains little established in our country with a prevalence of less than 1% of patients with end-stage renal disease. The objective of this work is to report the development and complications of PD in our center.

Patients and methods: This is a retrospective study including all patients on PD between October 2008 and March 2019. We noted their demographic and clinical data at their initiation in peritoneal dialysis and we followed their evolution to discuss infectious and mechanical complications as well as the causes of PD exit.

Results: During the study period, 456 patients were admitted for end-stage renal disease. Among these patients, only 28 (6.1%) were put on PD including two diabetics. Their average age was 37.7 years with a sex ratio of 0.8. The average body surface area was 1.59 m² with an average residual renal function of 6.05 ml / min. PD was chosen as the first intention in 20 patients while 8 patients were on hemodialysis. The evolution was marked by a median survival of the technique of 18.5 months characterized by 8 episodes of peritonitis in 4 patients corresponding to a rate of 1 episode over 56 months. Regarding mechanical complications, we noted 9 omentum aspirations, 1 leak in one case and 1 umbilical hernia requiring surgical recovery in a patient. Out of 28 patients, 17 discharges were identified; 10 patients (67%) were transferred to hemodialysis, 4 died and only 3 patients (18%) were transplanted. The final transfer to hemodialysis was related to mechanical complications in 5 cases, loss of ultrafiltration in one case, repeated hydro-sodium overload in one case, peritonitis in one case and social reasons in two cases.

Conclusion: PD is an effective technique which preserves residual renal function and quality of life but its prevalence remains low in the order of 6% of patients treated for end-stage renal disease. The complications are dominated in our context by the mechanical complications main cause of final transfer in hemodialysis.
Initiation à la manipulation de données avec le package dplyr
Authors: Della Vedova Claire
Published: November 2020

Résumé

NDLR : Le RDPLF a pour but principal d’être une aide pour permettre aux équipes de dialyse à domicile d’évaluer leurs pratiques cliniques et également conduire des études à partir d’exports anonymisés des données qu’elles saisissent. A cette fin, depuis juin 2019, un article de formation à l’utilisation du logiciel Libre R est publié trimestriellement à chaque parution du Bulletin de la Dialyse à Domicile. Le but est de permettre à toutes les équipes de réaliser des statistiques de bases et visualiser rapidement leur données.

Le premier article de cette série d’initiation était consacré au téléchargment et à l’installation du logiciel R sur les ordinateurs Macintosh et PC : https://doi.org/10.25796/bdd.v2i2.20513 .

Le second article était consacré à la visualisation graphiques des données statistiques avec le package Esquisse, simple d’utilisation et nécessitant peu d’apprentissage : https://doi.org/10.25796/bdd.v2i3.21313 Le troisième article était consacré à la visualisation graphiques avec le Package ggplot2 : https://doi.org/10.25796/bdd.v2i4.52303

Le quatrième article expliquait comment générer un rapport d’analyse automatiquement, et de façon dynamique, en utilisant “Rmarkdown” : https://doi.org/10.25796/bdd.v3i1.54523

Ce cinquième article est consacré à la manipulation des données avec le package dplyr : https://doi.org/10.25796/bdd.v3i1.54523

Comme dans les numéros précédent un fichier exemple, tiré de la base de données du RDPLF sera utlisé.
Association of polymorphisms of genes TCF7L2, FABP2, KCNQ1, ADIPOQ with the prognosis of the development of type 2 diabetes mellitus
Authors: Mel’nikova E. S. , Rymar O. D. , Ivanova A. A. , Mustafina S. V. , Shapkina M. Ju. , Bobak Martin , Maljutina S. K. , Voevoda M. I. , Maksimov V. N.
Published: November 2020

Aim.To study the possibility of using polymorphisms of genesTCF7L2,FABP2,KCNQ1,ADIPOQas markers for predicting the development of type 2 diabetes mellitus (T2D) in the population of Novosibirsk.
Materials and methods.On the basis of prospective observation of a representative population sample of residents of Novosibirsk (HAPIEE), 2 groups were formed according to the case-control principle (case people who had diabetes mellitus 2 over 10 years of observation, and control people who did not developed disorders of carbohydrate metabolism). T2D group (n=443, mean age 56.26.7 years, men 29.6%, women 70.4%), control group (n=532, mean age 56.17.1 years, men 32.7%, women 67.3%). DNA was isolated by phenol-chloroform extraction. Genotyping was performed by the method of polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism, polymerase chain reaction in real time. Statistical processing was carried out using the SPSS 16.0 software package.
Results and discussion.No significant effect of rs1799883 of theFABP2gene, rs2237892 of theKCNQ1gene, and rs6773957 of theADIPOQgene on the risk of developing T2D was found. Genotypes TT and TC rs7903146 of theTCF7L2gene are genotypes for the risk of developing T2D (relative risk RR 3.90, 95% confidence interval CI 2.316.61,p0.001; RR 1.86, 95% CI 1.422.43,p0.001, respectively). The CC genotype rs7903146 of theTCF7L2gene is associated with a protective effect against T2D (RR 0.37, 95% CI 0.290.49,p0.001). When theTCF7L2gene is included in the model for assessing the risk of developing T2D rs7903146, it retains its significance in both men and women.
Conclusion.The rs7903146 polymorphism of theTCF7L2gene confirmed its association with the prognosis of the development of T2D, which indicates the possibility of considering it as a candidate for inclusion in a diabetes risk meter. Variants of risk meters have been developed to assess the prognosis of the development of diabetes mellitus 2 in men and women aged 4569 years during 10 years of follow-up. The association with the prognosis of the development of T2D polymorphisms rs1799883 of theFABP2gene, rs2237892 of theKCNQ1gene and rs6773957 of theADIPOQgene was not found.
Early postoperative measurement of growth hormone level for prognosis of surgical outcomes in acromegaly
Authors: Tsiberkin A. I. , Tsoy U. A. , Cherebillo V. Yu. , Polezhaev A. V. , Kuritsyna N. V. , Paltsev A. A. , Alkhazishvili A. V. , Grineva E. N.
Published: November 2020

Aim.To investigate the value of 24 hours post-surgery measurement of growth hormone (GH) level for prognosis of surgical outcomes in acromegaly.
Materials and methods.A prospective cohort study included 45 patients with newly diagnosed acromegaly. The degree of parasellar extension was measured on the preoperative sellar magnetic resonance imaging according to the Knosps classification. All patients underwent a transsphenoid adenomectomy performed by one neurosurgeon. Basal GH level was measured at 24 hours after surgery. The efficacy of transsphenoidal adenomectomy evaluated at 12 months after surgery.
Results.Acromegaly remission was achieved in 19 (42%) of 45 patients at 12 months after surgery. Pituitary microadenomas and the absence of paracellular invasion, corresponding to Knosp Grade 02, had low prognostic value for long-term remission due to low sensitivity (31.6%) and low specificity (38.5%), respectively. The highest prognostic value for acromegaly remission was showed for 24 hours post-surgery GH level with cut-off 1.30 ng/ml with sensitivity of 96.2% (95% confidence interval 81.199.8%) and specificity of 84.2% (95% confidence interval 62.494.4%).
Conclusion.The study demonstrated the possibility of using GH level at 24 after surgery as a predictor for acromegaly remission. GH level 1.30 ng/ml at 24 hours after surgery showed better predictive value for long-term remission compared with the presence of microadenomas and Knosp Grade 02. The absence of decrease of GH level on the first day after surgery may serve as a reason for more close monitoring of patients in the postoperative period. Further studies in a larger number of observers are required to confirm our findings.
Iodine deficiency disorders as a non-infectious epidemic: a look at the problem at the tome of COVID-19 pandemic
Authors: Mel’nichenko G. A. , Troshina E. A. , Gerasimov G. A.
Published: November 2020

Radioactive iodine, flying out of the destroyed reactor of the Chernobyl nuclear power plant, like a corona virus quickly spread throughout Europe. Iodine deficiency in the regions of Ukraine, Belarus and Russia adjacent to nuclear power plants became a factor in increased uptake of radioactive iodine by the thyroid gland in children and after 5 years led to an epidemic of thyroid cancer. Optimal iodine intake could become a kind of vaccination, which sharply reduces the risk of developing thyroid cancer, as has happened after the accident at the Fukushima nuclear power plant in Japan. Endemic goiter was eliminated 50 years ago, but returned to the country in the early 1990s after the collapse of iodized salt production and has not been eliminated to this day due to the lack of a legislative framework for mandatory salt iodization. The actual average consumption of iodine by residents of Russia is from 40 to 80 mcg per day, which is 23 times less than the recommended norm. Mild and moderate iodine deficiency was detected throughout the Russian Federation, and it is more typical for the the rural population. The iodine deficiency has the greatest negative effect on the psychomotor development of the child during the critical period the first 1000 days of life from the moment of conception to the end of the second year of life. According to WHO, over the past 20 years, iodine deficiency has been eliminated in 115 countries of the world, and the number of iodine-deficient countries has dropped to 25, but Russia is still among them. We believe that after the COVID-19 pandemic, it will no longer be necessary to prove the need for effective support for the prevention of both infectious and non-infectious diseases, and the declared preventive direction of Russian medicine will indeed become such.
Angiogenesis system, as a part of endothelial dysfunction in patients with diabetes mellitus type 2: relationship with obesity
Authors: Severina A. S. , Shestakova M. V.
Published: November 2020

Aim.To investigate parameters of angiogenesis system in patients with diabetes mellitus and their relationship with obesity.
Materials and methods.104 patients with diabetes mellitus type 2 were included in the study. Patients were divided in 2 groups: Obesity+ (body mass index30 kg/m2;n=63) and Obesity- (body mass index 30 kg/m2;n=41). In all patients was performed clinico-diagnostical examination. mRNA expression levels of vascular endothelial growth factor (VEGF), its receptors flt-1 (fms-like tyrosine kinase 1), KDR (human kinase insert domain receptor) were determined in blood mononuclear cells.
Results.There were no statistically significant differences in investigated parameters between study groups. mRNA expression level of VEGF was slightly lower in men compared to women: 0.19 (0.14; 0.32)vs0.28 (0.12; 0.4) respectively,р=0.2236. MRNA expression level of flt-1 was lower in men compared to women: 0.14 (0.04; 0.3)vs0.25 (0.12; 0.38),р=0.0321 (statistically significant). We found statistically significant correlations of mRNA expression level of VEGF with mRNA expression level of flt-1 and KDR. Also we found strong positive correlations of BMI and mRNA expression levels VEGF, flt-1, KDR (r=0.86107,r=0.86125,r=0.86112, respectively,p0.001).
Conclusion.Results of the study displayed relationship of obesity and angiogenesis system condition in patients with diabetes mellitus type 2. Further investigations are perspective for the future as a way to new therapeutical approach of obesity and its complications treatment.
Deep infiltrative endometriosis. Contentious issues: pros and cons
Authors: Rusina Elena I. , Yarmolinskaya Maria I. , Piankova Valeriia O.
Published: November 2020

Relevance.Deep infiltrative endometriosis (DIE) is a particular form of endometriosis with a more severe symptoms and dysfunction of the neighboring organs. Inspite of the fact that in recent years, much had been done to understand the pathogenesis of the disease and its associated symptoms; there are still several unresolved issues. Aim.To describe debated issues of pathogenesis and management of patients with DIE using current data. Materials and methods. Foreign and domestic scientific articles on this topic that is available in PubMed database and on Internet resources have been examined over the past 5 years. Results.The review consisted of a system analysis of data on the pathogenesis of pain, infertility, the choice of conservative or surgical treatment in dealing with specific problems of managing patients with DIE. Conclusion.Despite there are different options of managing and treating, most specialists agree that the treatment strategy should be based on the assumption that it is a chronic recurrent disease. The treatment choice should be personal depending on the severity of symptoms, dysfunction of the neighboring organs affected by endometriosis, such as the intestines, bladder, ureters, as well as the womans age and reproductive life plans. Depending on the clinical case, it is possible to use various regimens of conservative management. Surgical management planning should be highly balanced. A radical surgery with removing foci of endometriosis performed by an experienced surgeon in a specialized hospital in coupled with pharmacotherapy and assisted reproductive technologies increases the patients chances of pregnancy, a healthy childbearing. Subsequent combination therapy provides a long-term remission. Pregnancy and childbirth in patients with deep infiltrative endometriosis should be considered as a high risk condition for the severe complications.
Recurrent vulvovaginitis and vaginosis. Possibilities of effective therapy
Authors: Prilepskaya Vera N. , Uruimagova Ada T. , Ivanova Angelina A.
Published: November 2020

Infectious and inflammatory diseases of the genitals caused by various opportunistic and pathogenic microorganisms arefound in 70% of all gynecological patients who seek help from medical institutions. Currently, scientists and clinicians in their practice are increasingly faced with insufficient effectiveness of treatment of vulvovaginitis and vaginosis, a tendency to a long and protracted course, recurrence of the process. One of the reasons for the longer and more severe course, the recurrence of the process is the increasingly common mixed infection with the possible simultaneous predominance of aerobes, anaerobes, andCandidafungi, which suggests the appointment of appropriate drugs. One of these drugs is Tergynan, which demonstrates a good clinical effect and tolerability of the drug in the treatment of recurrent vulvovaginitis and dysbiotic conditions of the lower genital tract.
Experience of pyomyoma treatment
Authors: Gabidullina Rushania I. , Mingazetdinov Marat A. , Druzhkowa Evgenya B. , Sirmatova Liaisan I.
Published: November 2020

Uterine pyomyoma is a rare and dangerous complication of uterine fibroids, which develops as a result of myomatous node infarction with the addition of an infectious component. In the literature there are descriptions of 50 cases of pyomyomas, half of which are associated with pregnancy. Incorrect diagnosis, lack of antibacterial and surgical treatment can lead to death of the patient. This article describes a clinical case of uterine piomioma development after the first birth by Caesarean section. Method of uterine artery embolization in combination with antibiotic therapy has helped keep the uterus of a young woman. On subsequent observation, menstrual function has fully recovered.
Features of the ovarian reserve of women of reproductive age suffering from autoimmune diseases
Authors: Andreeva Elena N. , Grigoryan Olga R. , Absatarova Yulia S. , Yarovaya Irina S. , Mikheev Robert K.
Published: November 2020

The reproductive potential of a woman depends on indicators of the ovarian reserve, such as the anti-Muller hormone (AMH) and the number of antral follicles (NAF). Autoimmune diseases have a significant effect on fertility and contribute to the development of premature ovarian failure.
Aim.To evaluate the parameters of the ovarian reserve in patients with type 1 diabetes mellitus, carriers of antibodies to the thyroid gland in a state of euthyroidism and compare them with similar parameters in healthy women.
Materials and methods.In the first block of the study, the level of AMH, follicle-stimulating hormone, luteinizing hormone, NAF was studied among 224 women with diabetes and 230 healthy women in the control group. In block II, the level of the above hormonal indices was studied in 35 carriers of antithyroid antibodies in the state of euthyroidism and 35 healthy women.
Results.In patients with type 1 diabetes, the level of AMH, NAF was statistically significantly lower when compared with the control group. Among carriers of antithyroid antibodies and healthy women, no difference in AMH and NAF was found.
Conclusion.The autoimmune processes accompanying diabetes are more influenced by the ovarian reserve indices than autoimmune aggression to the tissues of the thyroid gland.
Omega-3 polyunsaturated fatty acids in supporting pregnancy and fetal development: dosing considerations
Authors: Gromova Olga A. , Torshin Ivan Iu. , Grishina Tatiana R. , Maliavskaia Svetlana I.
Published: November 2020

Being complex regulators of inflammation processes omega-3-polyunsaturated fatty acids (PUFAs) are vitally important for supporting pregnancy and fetal development. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are the most important omega-3-PUFAs. The article presents the results of a systematic analysis of 1973 studies of dose-dependent effects of DHA and EPA in nutritional support of pregnancy. The analysis results suggest that DHA/EPA donations for pregnant women are effective only in doses of at least 200 mg/day. According to the analysis results, the optimal doses of DHA/EPA are in the 400- to 800-mg/day range. The dose of omega-3-PUFA for a particular patient can be assessed by the measurement of the DHA and EPA levels in the erythrocyte membrane. To achieve specific therapeutic effects (for example, lowering triglyceride levels, therapy for postpartum depression, etc.), higher doses of omega-3-PUFAs (35 g/day) may be required. With an adequate choice of dosing regimen, DHA / EPA donations have a beneficial effect on the somatic health of women of reproductive age, help to prevent pregnancy complications and determine the child development program in the subsequent years of life. DHA/EPA drugs are effective in the adjuvant therapy of various chronic disorders.
Current views on the molecular mechanisms of the initial stages of folliculogenesis
Authors: Marchenko Larisa A. , Mashaeva Roza I. , Chernukha Galina E.
Published: November 2020

The ovary is a unique structure of the female body, which simultaneously presents various morphohistological units-from primordial to dominant follicles. Over the past decades, scientists have focused on studying the mechanisms of folliculogenesis at the gonadotropin-dependent stage. While more complex and lengthy processes that determine the fate of the follicle occur from the moment of their recruitment to the preantral stage of maturity (about 290 days), another 60 days pass before the dominant maturity. Currently, it has been proved that intercellular communication is established within the follicle, which involves a bidirectional exchange of information between the oocyte and its companions granulose and Teka cells through auto-and paracrine interactions using various genes, growth factors and cytokines. The purpose of this review was to study intrafollicular factors that control the early stages of folliculogenesis and other disorders that may ultimately lead to the development of premature ovarian failure.
Beneficios de la práctica regular de actividad física y sus efectos sobre la salud para enfrentar la pandemia por Covid-19: una revisión sistemática
Authors: Ortiz Guzmán Johan Enrique , Villamil Duarte Angy Calorina
Published: November 2020

El Objetivo de este trabajo fue determinar la importancia de la práctica de actividad física (AF) durante el tiempo de aislamiento social y confinamiento, y sus efectos positivos para enfrentar las consecuencias sobre la salud física y mental, ocasionadas por el COVID-19. Para ello, se realizó una revisión sistemática de la literatura disponible en bases de datos especializadas PUBMED, SCIELO, EBSCO y OVID, la cual se ajustó a las directrices enmarcadas en la metodología PRISMA. Se definieron ecuaciones de búsqueda bajo los términos MESH: physical activity, exercise, sport, covid 19, sars cov 2 y utilizando caracteres booleanos AND y OR. Con estas ecuaciones se buscaron artículos publicados entre febrero y mayo de 2020, recuperando 53 registros en total e incluyendo en la revisión final 16 de ellos que cumplían con todos los criterios de inclusión y de exclusión definidos. Los resultados sugieren que la práctica regular de AF podría ser una herramienta importante para combatir los efectos adversos ocasionados sobre el organismo debido a la infección por COVID-19 y esto porque: a) mejora la respuesta del sistema inmunológico ante una posible infección por COVID-19; b) aumenta la acción del eje ECA2-Ang.1,7-Rec.Mas., el cual favorece estadios antiinflamatorios, antitrombóticos y disminuye el estrés oxidativo; c) disminuye la incidencia o ayuda en el control de las principales comorbilidades que predisponen al desarrollo de síntomas más severos y que aumentan el riesgo de mortalidad ante la infección por COVID-19. Con estos hallazgos se concluye que la práctica regular de AF es necesaria para enfrentar la actual situación de pandemia, ya que ayuda, no solo al mantenimiento de la buena condición de salud física y mental durante el periodo de aislamiento social y confinamiento, sino que también parece ofrecer una mejor respuesta ante la infección por COVID-19, disminuyendo el riesgo de mortalidad.
COVID-19: fisiopatología y propuestas terapéuticas en investigación clínica
Authors: Guzmán Valdivia Gómez Gilberto , Domínguez González Alejandro Daniel , Álvarez Rodríguez Santiago , Meneses Ruiz Dulce María
Published: November 2020

La pandemia por COVID-19 declarada por la Organización Mundial de la Salud el 11 de marzo del 2020, ha ocasionado al momento 6,287,771 casos y 379,941 muertes en todo el mundo.  Alrededor del 80% de las personas infectadas por SARS-CoV-2 son asintomáticos, el resto desarrolla la enfermedad COVID-19. Factores como edad, sexo y coexistencia de comorbilidades como hipertensión, diabetes y enfermedades cardiovasculares y del sistema respiratorio aumentan la gravedad de la enfermedad. Cuando la infección por SARS-CoV-2 alcanza el tracto respiratorio inferior, la respuesta inmune se acompaña de secreción intensa de citocinas y quimiocinas, dando lugar a edema y pérdida de la función de la unidad alveolo-capilar que sumado a la tormenta de citocinas da lugar a la falla orgánica múltiple. Esta revisión describe la fisiopatología relacionada con las manifestaciones clínicas del COVID-19 y presenta los principales fármacos estudiados en ensayos clínicos.
Presentación Editorial
Authors: Guadarrama Muñoz Alma Cossette , Meneses Ruiz Dulce María , Gómez Ramírez Eduardo , Salazar Juan Rodrigo , Flegl Martin , Vázquez Espinoza de los Monteros Roberto Antonio
Published: November 2020

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BRD2 regulation of sigma-2 receptor upon cholesterol deprivation
Authors: Shen Hongtao , Li Jing , Xie Xiujie , Yang Huan , Zhang Mengxue , Wang Bowen , Kent K Craig , Plutzky Jorge , Guo Lian-Wang
Published: November 2020

The sigma-2 receptor (S2R) has long been pharmacologically targeted for antipsychotic treatment and tumor imaging. Only recently was it known for its coding gene and for its role implicated in cholesterol homeostasis. Here, we have investigated the transcriptional control of S2R by the Bromo/ExtraTerminal epigenetic reader family (BETs, including BRD2, 3, and 4) upon cholesterol perturbation. Cholesterol deprivation was induced in ARPE19 cells using a blocker of lysosomal cholesterol export. This condition up-regulated S2R mRNA and protein, and also SREBP2 but not SREBP1, both transcription factors key to cholesterol/fatty acid metabolism. Silencing BRD2 but not BRD3 or BRD4 (though widely deemed a master regulator) averted S2R up-regulation that was induced by cholesterol deprivation. Silencing SREBP2 but not SREBP1 diminished S2R expression. Furthermore, endogenous BRD2 co-immunoprecipitated with the transcription-active N-terminal half of SREBP2, and chromatin immunoprecipitation-qPCR signified co-occupancy of BRD2, H3K27ac (histone acetylation), and SREBP2Nterm at the S2R gene promoter. In summary, this study reveals a previously unrecognized BRD2/SREBP2 cooperative regulation of S2R transcription, thus shedding new light on signaling in response to cholesterol deprivation.
Characterisation of undoped Zns and fecl3 doped Zns nanoparticles are synthesized by chemical precipitation method
Authors: Aarthe K G  , Kiruthika P
Published: November 2020

Nanoparticles of Ferric chloride (FeCl3) doped Zinc Sulphide (ZnS) and Undoped Zinc Sulphide (ZnS) had been synthesized successfully by simple chemical precipitation method. Particle sizes have been calculated from X-ray diffraction (XRD) analysis which confirms the nano structure of the samples. The Molecular structure of the compound was determined by the Fourier transform infrared spectroscopy (FTIR) analysis and the different vibrational bands confirmed the functional groups present in the sample. The bandwidth of the absorbance is examined by using (UV)-Visible Spectroscopy. The Morphological structures have been confirmed by using Scanning Electron Microscope (SEM). Energy Dispersive analysis of X-ray (EDAX) shows the composition of elements present in the nanoparticles. The applications of ZnS were used in the field such as Field Emitting Diodes (FET), sensors (gas sensors, biosensors), Flat panel displays, Electroluminescence.
Synthesis, characterization and antibacterial activities of calcium oxide nanoparticles by precipitation method
Authors: Gowthami R  , Keerthana G
Published: November 2020

The UV- Vis spectroscopy determines the band gap of calcium oxide nanoparticles and also the calcium oxide nanoparticles shows excellent antibacterial activity due to its degradation property.
Synthesis and characterization of iron Oxide (hematite) nanoparticles by sol-gel method
Authors: Jegadeeswari A  , Punitha T
Published: November 2020

Iron oxide nanoparticles have excellent biomedical applications because of its large surface area. It can be used in drug delivery, cell separation, tissue repair and MRI. A Fe2O3 nanoparticle is synthesized chemically by sol-gel method. This method uses Ammonium hydroxide and Ethanol as a precursor for forming Fe2O3 nanoparticles. Thus Fe2O3 nanoparticles are characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDAX) and UV Spectroscopy. All the structural parameters such as lattice constants, unit cell volume, density, crystalline size, micro strain are calculated from the XRD results using Debye Scherrer’s formula. When annealing temperature increased from 400oC to 1000oC the average crystalline size of the Fe2O3 nanoparticles are increased from 18nm to 22nm. FTIR technique also confirms functional groups of the synthesized Fe2O3 nanoparticles. The SEM image indicates that Fe2O3 nanoparticles are approximately spherical in shape. Band gap of the Fe2O3 nanoparticles is founded using UV Spectroscopy and it is reported in paper.
Exploring the characterization of Ni doped MgO nanoparticles using co-precipitation method
Authors: Muthulakshmi M  , Madhumitha G
Published: November 2020

Nanotechnology is a field of applied science focused on design, synthesis and characterization of nanomaterials. The nickel and magnesium have improved their applications in transparent electrodes and nano electronics. In addition, magnesium oxide has moisture resistance and high melting point properties. In the present work has been carried out in the development of green crystalline powder of nickel doped magnesium oxide nanoparticles by Co-precipitation method, from the mixture of nickel chloride and magnesium chloride with KOH as solvent. From the XRD results, crystalline size of the particle can be observed. Spherical structure of Ni doped MgO nanoparticles were indicated by SEM results and powdered composition of samples were obtained from FTIR. EDAX represents the peak composition of the nanoparticle. The above analytical techniques have confirmed that the Ni doped MgO nanoparticles obtained from the mixture of NiCl2 and MgCl2.
《黄帝内经∙四气调神大论》四季养生理论探析与生活实践
Authors: 周 琪 , 翟 珂
Published: November 2020

论文以《黄帝内经·四气调神大论》所讲述的四季养生理论为基础，结合现代养生知识，从精神养生、起居调养、饮食调养、运动调养、防病保健等五个方面分别对四季养生进行详细论述，以期人们能顺应四时气候变化，调摄精神活动，养成良好的生活、饮食习惯，积极锻炼身体，形成天人合一的态势，在快节奏、高强度的现代生活中早日摆脱“亚健康”的身体状态，达到防病保健、延年益寿的目的。
Método de agrupamento aplicado à avaliação escolar: um estudo de caso para avaliações de larga escala
Authors: Pereira Valberto Rômulo Feitosa , De Paula Anderson Damasceno , Araújo Cristian Oliveira
Published: November 2020

O presente artigo apresenta o método de agrupamento como uma solução para análise de dados em avaliações de larga escala na área de educação a fim de investigar as reais taxas de desenvolvimento estudantil. O estudo é fundamentado nos dados do SPAECE-2014 referentes ao desempenho dos alunos do Estado do Ceará que cursam os 2º, 5º e 9º anos do Ensino Fundamental nas disciplinas de Matemática e Português. Assim, faz-se uma investigação comparativa entre o método proposto e método já adotado pelo SPAECE para apontar qual dos dois é mais fidedigno à realidade escolar. Concluindo-se, portanto, que o método de agrupamento forneceu dados mais precisos e, por essa razão, seus resultados devem ser considerados no desenvolvimento das políticas públicas educacionais.
Infância, gênero e o brincar em um projeto de educação social
Authors: Furlan Cássia Cristina , Silva Bruna Fernanda da
Published: November 2020

Este artigo tem por objetivo analisar as questões relativas às desigualdades entre meninos e meninas nas relações desenvolvidas no brincar das crianças participantes de um projeto de Educação Social desenvolvido no Vale do Ivaí-PR. É uma pesquisa de cunho qualitativo que utiliza técnicas etnográficas. Na pesquisa, realizamos observações participantes e análise dos relatórios produzidos por educadores/as atuantes no projeto, após as intervenções e entrevistas semiestruturadas com as crianças e os/as educadores/as. A análise de dados baseou-se no método de análise de conteúdo de Bardin (1997). Apontamos que ainda há diferenças de gênero no brincar de meninas e meninos participantes do projeto, as quais ocorrem de maneiras sutis, ficando mais evidentes em práticas binárias já enraizadas na cultura dominante, como em jogos/esportes tradicionais. No decorrer da pesquisa, observamos que as crianças ainda reproduzem muitos aspectos normativos, no entanto também conseguem ressignificar algumas normas de gênero, muitas vezes sem se darem conta.
As Disciplinas de Estudos Sociais na formação geral do docente no Projeto Logos II
Authors: Gromann de Gouveia Cristiane Talita , Gouveia Neto Sérgio Candido de
Published: November 2020

O Logos II foi um projeto destinado à formação do professor, entre as décadas de 1970 e 1990, que funcionou a distância e utilizava o sistema modular. Foi implantado em 19 entes da Federação e o Território Federal de Rondônia estava entre eles. A grade curricular do Projeto Logos II era composta por 28 disciplinas, dividida em duas categorias (Geral e Especial), sendo a primeira de formação de 2º grau. Nesse rol de disciplinas de formação geral, figuravam as da área de Estudos Sociais (História, Geografia, Educação Moral e Cívica (EMC) e Organização Social e Política do Brasil (OSPB)). Mas, do que tratavam essas disciplinas de Estudos Sociais? Para tentar responder essa e outras questões, o presente artigo tem como objetivo elaborar uma história sobre as disciplinas de Estudos Sociais no Projeto Logos II. Como fontes, foram utilizados os módulos das disciplinas acima, bem como as legislações (pareceres, portarias, decretos, entre outros.), além de outros documentos. Como referencial teórico-metodológico, utilizou-se o Paradigma Indiciário de Ginzburg (1989) e a triangulação de dados de Mathison (1988). Os resultados indicam que, no Projeto Logos II, as disciplinas de Estudos Sociais apresentavam a visão do Governo da época sobre os contextos políticos, econômicos e sociais.
Estágio supervisionado na educação infantil: a professora é surda, e agora?
Authors: Rodrigues Marlene , Silva Isabella Dos Santos Oliveira da , Oliveira Josilene Silva de , Mendonça João Guilherme Rodrigues , Oliveira Vanderneide Costa de
Published: November 2020

O ensaio versa sobre experiências de observação, participação e regência durante um estágio supervisionado na Educação Infantil. Esse estágio foi desenvolvido com alunos da creche e da pré-escola em uma escola municipal em Porto Velho, Rondônia, no primeiro semestre de 2019. Elaboramos dois projetos didáticos: um para a creche, denominado “Cores, emoções e movimento!”, e outro para a pré-escola, denominado “Vogais em ação”. Ambos foram conduzidos em Língua Portuguesa e em Língua Brasileira de Sinais (Libras) por uma universitária ouvinte e outra surda. O texto apresenta parte das observações de campo e das reflexões desenvolvidas durante e após a execução do estágio. A partir disso, refletimos sobre as ações desenvolvidas e sobre o relevante papel da Universidade na formação de professores de modo a propor novas possibilidades para a ação docente na atualidade. Conclui-se que o estágio ampliou o nosso olhar sobre a inclusão de pessoas com deficiência no espaço escolar, seja na condição de estudantes ou na condição de docentes com deficiência.