bluuebunny/crossref_metadata_2025 huggingface dataset:
Platelet-Derived Growth Factors Affect Clinical Features and Prognosis of Gastric Cancer
Authors: Zhao Xia , Yu Zhihao , Zang Ku
Published: August 2022

Purpose. To investigate the association of platelet-derived growth factors (PDGFs), clinicopathological features, and prognosis in gastric cancer patients. Methods. Tumor specimens of 180 individuals with gastric cancer treated between 2016 and 2020 were collected. Immunohistochemical staining and Western blot (WB) were used to detect the expression of PDGF-B and PDGF-D. The relationship between the expression of PDGF-B and PDGF-D and relapse-free subsistence (RFS) time was assessed using Kaplan–Meier curves. Univariate and multivariate Cox proportional hazards regression models were used to evaluate the relationship between the expression of PDGF-B and PDGF-D and the prognosis and clinicopathological features in gastric cancer patients. Results. High expression of PDGF-B and PDGF-D was detected in 108 (60%) and 137 (76%) tumor specimens, respectively. The expressions of PDGF-B and PDGF-D were independent predictive indicators in multivariate analysis when compared to tumor depth, tumor stage, lymph node metastasis, and RFS (

P
<
0.01

). Conclusion. The high expression of PDGF-B and PDGF-D in gastric cancer tissues is associated with poor prognosis and poor survival rate of the patients. The expression of PDGF-B and PDGF-D can be used as important indicators to evaluate the biological behavior and prognosis of gastric cancer.
Network Media Public Opinion and Social Governance Supported by the Internet-of-Things Big Data
Authors: Zhao Yixin , Miao Ruomu
Published: August 2022

The purpose is to make for the traditional Network Public Opinion (NPO) analysis methods’ inadequacy in the era of big data and provide a sufficient decision-making basis for managers. Based on the Internet of Things (IoT) and big data, this work applies Natural Language Processing (NLP) to NPO analysis. Additionally, it takes the content of Microblog text format as the main collection target, constructs a big data collection tool, and establishes Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), Deep Pyramid Convolutional Neural Network (DPCNN) based on Tensorflow and other deep learning models. It is also improved in combination with the characteristics of the model, and a new model is proposed. Finally, the performance of various models is compared and analyzed through experiments, and the path is proposed for the government to use big data to improve the ability to govern NPO and help social governance. The results show that the improved LSTM model can correctly classify the extracted Microblog text’s emotion by as much as 80.00%. It improves the classification accuracy by nearly two percentage points under the ideal condition. Thus, by adding residual connection and attention mechanism, the model can extract the emotional features in the text better and improve the emotional discrimination ability. The public opinion of online media without effective control will have great security risks to social governance under the big data and IoT. The proposed method is of great help in analyzing NPO through the accurate analysis of Microblog text.
Colon Cancer Metastasis to the Right Testis: Case Report and Review of Literature
Authors: Kasahara Mizuki , Shimizu Tomo , Aoki Hiroshi , Okawa Mizuho , Yamabe Fumito , Kobayashi Hideyuki , Nagao Koichi , Nakajima Koichi , Mitsui Yozo
Published: August 2022

Introduction. A metastatic testicular tumor is uncommon. We report here a case of testicular metastasis associated with recurrent colorectal cancer. Case Presentation. A 75-year-old male was presented with right scrotum pain one year after undergoing a right hemicolectomy combined with resection of the small intestine and omentum for ascending colon cancer (pT4N0M0). Magnetic resonance imaging of the pelvis showed a

7.3
×
5.4
×
4.5

 cm mass consisting of a cystic solid tumor. A right inguinal orchiectomy was performed and right testicular pain improved after surgery. Pathology results showed that the tumor was a metastatic adenocarcinoma. The patient subsequently died two months later due to progression of the colon cancer. Conclusion. Although colorectal cancer metastasis to the testis is very uncommon, it should be kept in mind in clinical situations, especially for older males with a testicular mass or discomfort.
Evaluation of Thermal Insulation Performance of Building Exterior Wall Based on Multiobjective Optimization Algorithm
Authors: Liang Dong , Jing Feng
Published: August 2022

A complete evaluation of conflicting and nonlinear multiperformance is referred to as an evaluation system. Therefore, multiobjective optimization research for building performance is of great importance. Considering the above problems, this paper proposes a multiobjective performance optimization platform at the architectural design stage. The optimization research is combined with the basic algorithms. It is based on Grasshopper software. It aims to provide a fast and effective method for the optimization design of sustainable buildings. It is important to note that this workflow has no restrictions on what to optimize for or what to target, and can be determined on a case-by-case basis. To evaluate the use of the work platform and make the research results more extensive, the standard model of the inner corridor space building in office buildings in cold areas was extracted. The extracted standard model was taken as the final research object. At the same time, the convergence, distribution, and comprehensive evaluation indexes of the simulation results were analyzed. The quantitative influence parameter system of window parameters on the total building energy consumption, lighting uniformity, and glare probability was established. A series of parametric design models based on the comprehensive optimal solution of building energy consumption and lighting quality was obtained. The main purpose of this paper is to design a green building design method based on the principle of goal-oriented design. This paper, combined with the group search function of nondominated genetic algorithm (NSGA-II), the energy consumption of the building, and the evaluation function of indoor thermal and humid environment, is obtained and linked with MATLAB. The energy consumption of residential buildings and indoor thermal comfort were taken as the optimization objectives of the design scheme. The automatic optimization model of the architectural design scheme was established. Finally, the Pareto solution set of the architectural design scheme is obtained, and the designer can select the appropriate design scheme of the Pareto solution set according to the actual situation of the project, to meet the requirements of green building design. The design scheme optimized by this method can effectively reduce building energy consumption and improve indoor thermal comfort.
Genotoxicity Evaluation of Metformin in Freshwater Planarian Dugesia japonica by the Comet Assay and RAPD Analysis
Authors: Yin Dandan , Xu Zhenbiao , Feng Minmin , Zhao Zelong , Chen Dahu , Song Linxia
Published: August 2022

Objective. To investigate the genotoxicity of metformin on planarian with different concentrations and exposure times. Methods. The planarians were treated, respectively, with 10 mmol/L and 50 mmol/L metformin for 1, 3, and 5 days, and then, the comet assay and random amplified polymorphic DNA (RAPD) analysis were performed. 13 random primers were used for PCR amplification with the genomic DNAs as templates. Planarians cultured in clear water were used as the control. Genomic template stability (GTS) was calculated by comparing and analyzing the RAPD patterns of the control group and the treatment groups. Results. In the comet assay, DNA damage of planarians treated with 10 mmol/L metformin for 1, 3, and 5 days was 10.2%, 25.4%, and 36.8%, respectively, and that of planarians treated with 50 mmol/L metformin was 40.6%, 62.8%, and 65.4%, respectively. GTS values of planarians exposed to 10 mmol/L metformin for 1, 3, and 5 days were 64.1%, 62.8%, and 52.6%, respectively, and those of planarians exposed to 50 mmol/L metformin for 1, 3, and 5 days were 52.6%, 51.3%, and 50%, respectively. DNA damage increased and GTS values decreased with the increasing metformin exposure concentration and exposure time. Conclusion. Metformin has certain genotoxicity on planarian in a dose‐ and time‐related manner. The comet assay and RAPD analysis are highly sensitive methods for detecting genotoxicity with drugs.
Comparison of Farmland Ecosystem Value in Core Area of Hakka Terrace System in Chongyi, Jiangxi Province
Authors: Li Hua , Guo Yangdong , Liu Hao , Chen Feiping
Published: August 2022

Objective. This paper hopes to lay a foundation for properly understanding the role of the Hakka terrace system in the future development of agricultural economy by evaluating and comparing the values of the farmland ecosystem in the core area of The Hakka terrace system in Chongyi, Jiangxi province, in the year 2013 and 2019. Methods. By sorting out the evolution of Chongyi Hakka terrace system, we can figure out the corresponding multidimensional values obtained in rural revitalization process, thus forming the value evaluation system, calculating the values of each value system in 2013 and 2019, analyzing and comparing the reasons behind numerical changes, and making suggestions accordingly. Results. In the year 2013, the economic value, ecological value, social value, and cultural value of the farmland ecosystem accounted for 11.72%, 6.15%, 80.36%, and 1.77% of the total value. In the year 2019, the figure is 19.22%, 2.75%, 76.67%, and 1.36%, respectively. Conclusion. The noneconomic value of terrace ecosystem far exceeds its economic value, so the utilization rate of farmland production should be increased based on the local conditions so as to maximize the value of the agricultural system and boost rural revitalization.
Pharmacotherapies for Central Post-Stroke Pain: A Systematic Review and Network Meta-Analysis
Authors: Bo Zheng , Jian Yang , Yan Li , Gangfeng Gu , Xiaojing Luo , Xiaolan Luo , Zhao Chen , Ke Huang , Yang Fan , Maoxia Li , Jian Wang
Published: August 2022

Background. Central post-stroke pain (CPSP) is a common condition. Several pharmacotherapies have been applied in practice. However, the comparative effectiveness among these pharmacotherapies is unknown. Aim. The aim of this study is to study the comparative effectiveness among differential pharmacotherapies for CPSP through a network meta-analysis. Methods. We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science from inception to 30 March 2022, without any language restriction. Two reviewers independently screened the retrieved articles, extracted data, and evaluated the risk of bias (RoB). The outcome of interest of the study was the change in the scores of pain intensity scales. We estimated standard mean differences (SMDs) between treatments and calculated corresponding 95% CIs. Results. Thirteen randomized controlled trials (529 participants) were included after a screen of 1774 articles. Compared with placebo, pamidronate (SMD -2.43, 95% CI -3.54 to -1.31;

P
−
score
=
0.93

), prednisone (SMD -2.38, 95% CI -3.09 to -1.67;

P
−
score
=
0.92

), levetiracetam (SMD -2.11, 95% CI -2.97 to -1.26;

P
−
score
=
0.87

), lamotrigine (SMD -1.39, 95% CI -2.21 to -0.58;

P
−
score
=
0.73

), etanercept (SMD -0.92, 95% CI -1.8 to -0.03;

P
−
score
=
0.59

), and pregabalin (SMD -0.46, 95% CI -0.71 to -0.22;

P
−
score
=
0.41

) had significantly better treatment effect. Pamidronate, prednisone, and levetiracetam ranked as the first three most effective treatments. In subgroup analyses, prednisone, levetiracetam, lamotrigine, and pregabalin were more effective than placebo as oral pharmacotherapies, while etanercept was more effective than placebo as injectable pharmacotherapy. Conclusions. Our study confirmed that pamidronate, prednisone, and guideline-recommended anticonvulsants were effective for reducing pain intensity for CPSP. Pamidronate and prednisone showed better effect than other pharmacotherapies, which warrants further investigation.
An Overview of the Advances in Research on the Molecular Function and Specific Role of Circular RNA in Cardiovascular Diseases
Authors: Yin Lianli , Tang Yinghua , Yuan Yulin
Published: August 2022

In recent years, the rate of residents suffering from cardiovascular disease (CVD), disability, and death has risen significantly. The latest report on CVD in China shows that it still has the highest mortality rate of all diseases in that country. Different from linear RNA, circular RNA (circRNA) is a covalently closed transcript, mainly through reverse splicing so that the 3′end and the 5′end are covalently connected to form a closed loop structure. It is structurally stable and abundant and has distinct tissue or cell specificity, and it is widely distributed in eukaryotes. Although circRNAs were discovered many years ago, researchers have only recently begun to slowly discover their extensive expression and regulatory functions in various biological processes. Studies have found that some circRNAs perform multiple functions in cells more used as RNA binding protein or microRNA sponge. In addition, accumulating evidence shows that the first change that occurs in patients with various metabolic diseases such as hypertension and cardiovascular disease is dysregulated circRNA expression. For cardiovascular and other related blood vessels, circRNA is one of the important causes of various complications. These findings contribute to a more comprehensive understanding and grasp of CVD, and the related molecular mechanisms of CVD should be further analyzed. Here, we review the new understanding of circRNAs in CVD and explain the role of these innovative biomarkers in the analysis and determination of other related cardiovascular events such as coronary heart disease. Thus, this study is aimed at providing new ideas and proposing more feasible medical research strategies based on circRNA.
GC-MS Analysis, Antibacterial and Antioxidant Potential of Ethyl Acetate Leaf Extract of Senna singueana (Delile) Grown in Kenya
Authors: Ochieng Nyalo Paul , Isanda Omwenga George , Piero Ngugi Mathew
Published: August 2022

Bacterial diseases are a leading cause of mortality and morbidity globally. During bacterial diseases, an elevation of host immune response occurs, which involves the production of free radicals in response to the bacterial infection. The overproduction of free radicals in excess of the antioxidants leads to oxidative stress. Conventional antibiotics are linked to side effects such as hypersensitivity reactions in addition to bacterial pathogens developing resistance against them. Artificial antioxidants are said to be carcinogenic. This study sought to confirm folklore use and validate the antibacterial and antioxidant potential of Senna singueana which has been widely used in the Mbeere community. The in vitro antibacterial potentials of the plant extract were investigated on Bacillus subtilis ATCC 21332, Escherichia coli ATCC 25922, Salmonella typhi ATCC 1408, and Staphylococcus aureus ATCC 25923. Ciprofloxacin (100 µg/ml) drug was used as a standard reference, whereas 5% DMSO was used as a negative reference. The antibacterial tests included disc diffusion and minimum inhibitory and bactericidal concentrations. S. singueana ethyl acetate extract showed broad-spectrum potential against tested bacterial microbes producing mean zones of inhibition (MZI) from 07.67 ± 0.33 to 17.67 ± 0.33 mm. The extract demonstrated a greater effect on Gram-positive than Gram-negative bacterial pathogens. Antibacterial properties of ciprofloxacin were significantly greater in comparison to plant extract in all the dilutions (

p
<
0.05

), while 5% DMSO was inactive against all the tested bacteria. MBC values were greater than MIC values. Antioxidant properties of the extract were determined through scavenging effects of DPPH and hydroxyl radicals (•OH) as well as ferric reducing antioxidant potential (FRAP) assay. S. singueana demonstrated effects against all radicals formed. Additionally, the extract exhibited ferric reducing abilities. The extract also contained various phytocompounds with known antibacterial and antioxidant properties. This study recommends the therapeutic use of S. singueana as an antibacterial as well as an antioxidant agent.
Navigation Signal Radio Frequency Channel Modeling and Predistortion Technology Based on Artificial Intelligence Technology and Neural Network
Authors: Sun Liying , Chu Peng , Zhu Rui
Published: August 2022

Digital predistortion technology is widely used in wireless communication. As a vital part of wireless communication system, the predistortion technology of radio frequency power amplifier has always been a hot and difficult topic. This paper will research and explore the key technologies of radio frequency channel construction and predistortion of navigation information through artificial intelligence technology and neural network. The article first conducts a simple research on a new generation of artificial intelligence systems--artificial intelligence is an engineering technology scientific research that develops theories, methods, skills, and application systems for modeling, scaling, and amplifying collective human knowledge. Then, the article combines neural network algorithms. BP network is not only a part of synthetic neural network but also a multiple layer fed-forward network. Finally, a neural network method is proposed to model and predistort the load channel model. Then, the RF channel distortion model can be constructed, and the RF channel modeling simulation experiment and the RF channel predistortion simulation experiment are carried out. The experimental results of this paper showed that compared with the situation without predistortion, the two indicators of the zero-crossing slope distortion and the zero-crossing offset of the discriminant function of the output signal of the channel with predistortion had been greatly improved. Overall, the neural network-based model outperformed the RVTDNN model by 30% on these two metrics. It also indicated that the neural network model could model and predistort the cascade model well, and the new model had better modeling accuracy and predistortion effect than the RVTDNN model.
Risk Assessment of an Existing Metro Tunnel in Close Proximity to New Shield Tunnels following Construction
Authors: Xu Yong , Xia Ming , Zhang Wei , Li Zheyu , Zhang Zhiqiang
Published: August 2022

The construction of a new shield tunnel near an existing operating tunnel poses a great risk to the existing tunnel structure due to the continuous encryption of the rail transit network. This study investigated the safety status of an existing metro tunnel in close proximity to new shield tunnels following construction. A fuzzy comprehensive assessment model (hierarchical fuzzy comprehensive evaluation model) based on an analytic hierarchy process was proposed to assess the risks of the existing tunnel structure. The threshold of indicators in the existing tunnel structure risk assessment system was determined based on the tunnel function and structure security. Then, we described the membership vector determination method, weight vector determination method, and comprehensive evaluation vector processing method. Taking a project case in China as the research object, the quantitative analysis of the established evaluation system was carried out, and the intuitive risk assessment results were obtained. The hierarchical fuzzy comprehensive evaluation model can be employed as a decision-making tool for newly built shield tunnels passing through the existing tunnels, which can provide guidance for tunnel maintenance and guarantee.
Deep Learning‐Based Computed Tomography Features in Evaluating Early Screening and Risk Factors for Chronic Obstructive Pulmonary Disease
Authors: Zhang Changhong , Liu Jianhua , Cao Liang , Feng Gaixia , Zhang Zhihua , Ji Mengmeng , Zhang Yaping
Published: August 2022

This research aimed to investigate the diagnostic effect of computed tomography (CT) images based on a deep learning double residual convolution neural network (DRCNN) model on chronic obstructive pulmonary disease (COPD) and the related risk factors for COPD. The questionnaire survey was conducted among 980 permanent residents aged ≥ 40 years old. Among them, 84 patients who were diagnosed with COPD and volunteered to participate in the experiment and 25 healthy people were selected as the research subjects, and all of them underwent CT imaging scans. At the same time, an image noise reduction model based on the DRCNN was proposed to process CT images. The results showed that 84 of 980 subjects were diagnosed with COPD, and the overall prevalence of COPD in this epidemiological survey was 8.57%. Multivariate logistic regression model analysis showed that the regression coefficients of COPD with age, family history of COPD, and smoking were 0.557, 0.513, and 0.717, respectively (P < 0.05). The diagnostic sensitivity, specificity, and accuracy of DRCNN‐based CT for COPD were greatly superior to those of single CT and the difference was considerable (P < 0.05). In summary, advanced age, family history of COPD, and smoking were independent risk factors for COPD. CT based on the DRCNN model can improve the diagnostic accuracy of simple CT images for COPD and has good performance in the early screening of COPD.
Design and Analysis of Home Control Complex System Based on PLC Technology
Authors: Chen Jiangyu
Published: August 2022

The wide application of communication, automation, computer and other technologies not only provides a new direction for the development of home furnishing, but also makes the concept of “smart home” popular in recent years. The purpose of this study is to design a complex control system for smart healthcare home based on PLC technology. First, the research significance and background of this study are discussed, and the complex system, traditional PID control, and BP neural network algorithm are summarized. Second, the ZigBee wireless sensor network and PLC control system are studied, and the design of a smart health home control complex system based on PLC technology is analyzed. The experimental results show that when the indoor natural gas concentration is more than 1.25%, Y4 and Y3 are powered on, and Y2 is set as 1, that is, the alarm light is on, and the windows and exhaust fans are on. When the indoor flue gas (CO and CO2) concentration exceeds 0.06%, Y4 and Y3 are powered on, Y2 is set as 1, the alarm light is on, and the window exhaust fan is on. When the infrared detection output is 1, Y4 is powered on, Y2 is reset, the window is closed, and the alarm light is on. The human-machine interface of the Android mobile terminal of this system can be directly operated by the user and real-time monitoring data, reflecting the convenience of the design. Therefore, the design of complex home control system is of great significance in the home industry.
Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential
Authors: Mitra Saikat , Muni Maniza , Shawon Nusrat Jahan , Das Rajib , Emran Talha Bin , Sharma Rohit , Chandran Deepak , Islam Fahadul , Hossain Md. Jamal , Safi Sher Zaman , Sweilam Sherouk Hussein
Published: August 2022

Tacrine is a drug used in the treatment of Alzheimer’s disease as a cognitive enhancer and inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has been restricted due to its poor therapeutic efficacy and high prevalence of detrimental effects. An attempt was made to understand the molecular mechanisms that underlie tacrine and its analogues influence over neurotherapeutic activity by focusing on modulation of neurogenesis, neuroinflammation, endoplasmic reticulum stress, apoptosis, and regulatory role in gene and protein expression, energy metabolism, Ca2+ homeostasis modulation, and osmotic regulation. Regardless of this, analogues of tacrine are considered as a model inhibitor of cholinesterase in the therapy of Alzheimer’s disease. The variety both in structural make-up and biological functions of these substances is the main appeal for researchers’ interest in them. A new paradigm for treating neurological diseases is presented in this review, which includes treatment strategies for Alzheimer’s disease, as well as other neurological disorders like Parkinson’s disease and the synthesis and biological properties of newly identified versatile tacrine analogues and hybrids. We have also shown that these analogues may have therapeutic promise in the treatment of neurological diseases in a variety of experimental systems.
Review on Li-Ion Battery vs Nickel Metal Hydride Battery in EV
Authors: Arun Vijayakumar , Kannan R. , Ramesh S. , Vijayakumar M. , Raghavendran P. S. , Siva Ramkumar M. , Anbarasu P. , Sundramurthy Venkatesa Prabhu
Published: August 2022

Currently, electric cars are receiving a lot of attention because of their low fuel consumption and pollution-free nature. The efficiency of electric vehicles is constantly being improved via a variety of studies and applications. The battery is a significant portion of an electric vehicle’s overall component count. Because the electric vehicle’s battery acts like the vehicle’s heart, battery performance and efficiency in electric vehicles (EVs) are examined in this research.
Vocal Music Teaching Brands Recommendation Based on Review Mining and Multicriteria Decision-Making
Authors: Yu Zhenming
Published: August 2022

In the process of continuous improvement in the quality of vocal music teaching, new opportunities and challenges are ushered in. Teachers need to actively develop innovative and creative teaching activities in line with the teaching objectives and tasks of the new curriculum reform, enhance students’ application and mastery of knowledge points, and provide a boost to students’ high-quality practical learning activities. This paper proposes a method for recommending vocal teaching brands based on review mining and multicriteria decision-making. Firstly, a large number of student reviews are crawled from various university platforms in China, matching student views to lexical combinations of course opinions. The weight of each opinion indicator was calculated by using hierarchical analysis in multicriteria decision-making, and 35 teachers and students were asked to do paired comparison and scoring for the indicators. The results of the experiment suggest improvements to the recommended vocal teaching brands, with practical implications for the design and improvement of vocal music teaching.
Class II Malocclusion Treatment by In-House Fabricated, Customized Fixed Functional Appliance in Growing Child
Authors: Verma Swati , Mehta Falguni , Alam Mohammad Khursheed , Parekh Harshikkumar Arvindbhai , Ahmed Valai Kasim Shakeel , Jain Chhavi
Published: August 2022

Currently, wide arrays of fixed functional appliances are available for the correction of Class II malocclusion. The orthodontist must choose from these appliances depending on the mechanics, efficiency, and cost of the appliance. Fixed functional appliances may reduce the individual visits and hence the cost as compared to the removable appliances. Additionally, it may save the clinician’s chair time. This report discussed the in-house laboratory fabrication and clinical procedure of customized fixed functional appliances by utilizing the readily available dental materials in the orthodontic clinical setting.
Nonlinear Constitutive Model of High-Temperature Viscoelastic Deformation of Gussasphalt Concrete
Authors: Zhang Shunxian , Sha Aimin , Lu Xu , Nie Wen , Li Weixiong , Yan Junjian
Published: August 2022

To accurately evaluate the high-temperature stability of cast asphalt concrete, based on the traditional viscoelastic mechanical model, this paper innovatively improves the traditional viscoelastic mechanical model considering the conditions of temperature and dynamic load and deduces the viscoelastic constitutive model of high-temperature deformation performance of cast asphalt concrete, using a dynamic penetration test (DPT) to regress improved the Burgers model parameters and verify the model’s applicability and reliability. The results show that for the modified Burgers model parameters, E1, E2, A, and η2 decrease with increasing temperature, while parameter B increases with the increase of temperature. The high-temperature deformation of cast asphalt concrete is mainly related to η1, and η1 decreases, and deformation increases with the increase in temperature. With the increase in loading times, the dynamic penetration of cast asphalt concrete (AC) gradually increases, that is, when the greater the permanent deformation is. When the specimen is loaded 3000 times, the dynamic penetration value at 60°C is about 1.237 mm, and the dynamic penetration value at 50°C is about 0.819 mm. Under other loading times, the permanent deformation of the specimen at 60°C is much greater than that at 50°C. There is a good fit between the mechanical model derived from the viscoelastic theory and the measured test data, and the correlation coefficient is greater than 0.98, indicating that the model can accurately describe the permanent deformation law of GA under periodic semivector sinusoidal pulse load at high temperatures. The research results of this paper provide a solid theoretical basis for the promotion and application of cast asphalt concrete, and the method has wide applicability in practical engineering.
The Effect of Bariatric Surgery on Circulating Levels of Lipoprotein (a): A Meta‐analysis
Authors: Jamialahmadi Tannaz , Reiner Željko , Alidadi Mona , Kroh Matthew , Almahmeed Wael , Ruscica Massimiliano , Sirtori Cesare , Rizzo Manfredi , Santos Raul D. , Sahebkar Amirhossein
Published: August 2022

Background. Obesity, especially severe obesity, is associated with a higher risk of atherosclerotic cardiovascular disease (ASCVD) morbidity and mortality. Bariatric surgery is a durable and effective weight loss therapy for patients with severe obesity and weight‐related comorbidities. Elevated plasma levels of lipoprotein (a) (Lp(a)) are causally associated with ASCVD. The aim of this meta‐analysis was to analyze whether bariatric surgery is associated with Lp(a) concentrations. Methods. A literature search in PubMed, Scopus, Embase, and Web of Science was performed from inception to May 1st, 2021. A random‐effects model and the generic inverse variance weighting method were used to compensate for the heterogeneity of studies in terms of study design, treatment duration, and the characteristics of the studied populations. A random‐effects metaregression model was used to explore the association with an estimated effect size. Evaluation of funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests were used to assess the presence of publication bias in the meta‐analysis. Results. Meta‐analysis of 13 studies including 1551 patients showed a significant decrease of circulating Lp(a) after bariatric surgery (SMD: ‐0.438, 95% CI: ‐0.702, ‐0.174, p < 0.001, I2: 94.05%). The results of the metaregression did not indicate any significant association between the changes in Lp(a) and duration of follow‐up after surgery, reduction in body mass index, or baseline Lp(a) concentration. The reduction in circulating Lp(a) was robust in the leave‐one‐out sensitivity analysis. Conclusion. Bariatric surgery significantly decreases circulating Lp(a) concentrations. This decrease may have a positive effect on ASCVD in obese patients.
Neuroprotective Effect of Polyherbal Recipe Containing Ginger, Chinese Date, and Wood Ear Mushroom against Ischemic Stroke with Metabolic Syndrome Condition via Epigenetic Modification of Inflammation and Oxidative Stress
Authors: Nakyam Thuntiva , Wattanathorn Jintanaporn , Thukham-mee Wipawee
Published: August 2022

Currently, the prevalence of stroke with metabolic syndrome (MetS) is increasing and the current therapeutic efficiency is still limited. Therefore, the applications of herbal recipes have gained much attention. The polyherbal recipe containing ginger, Chinese date, and wood ear mushroom is reputed for atherosclerosis and stroke prevention. It has been long‐term consumed without scientific support. Therefore, this study was carried out to determine the neuroprotective effect and its mechanisms in animal model of ischemic stroke with MetS. Male Wistar rats weighing 180‐220 g were exposed to a 16‐week high‐fat high‐carbohydrate feeding. The rats with the MetS characteristic were exposed to a temporary occlusion of the right middle cerebral artery (MCAO) for 90 minutes. They were orally fed with the polyherbal recipe (GCJ) at the doses of 100, 200, and 300 mg/kg BW for 21 days and assessed the neurological deficit, ion volume, cortical neuron density in the cerebral cortex, oxidative stress status, inflammation, and expressions of histone deacetylase 3 (HDAC3) and DNA methyltransferase 1 (DNMT1). The results showed that GCJ significantly improved all mentioned parameters. Therefore, GCJ is the potential neuroprotectant against ischemic stroke with MetS. The underlying mechanisms may involve the reduction of oxidative stress, inflammation, and the modification of epigenetic mechanism via the reduction of HDAC3 and DNMT1. However, further clinical investigation is essential to confirm this positive modulation effect.
A Composite Service Provisioning Mechanism in Edge Computing
Authors: Zhang Junna , Zhao Xiaoyan , Wang Yali , Yuan Peiyan , Zhang Xinglin
Published: August 2022

Users can invoke various composite services in Edge Computing (EC) with the development of Service Computing. Generally, users cannot invoke the optimal composite service due to the migration of component service or failure in the edge device. In this study, a Composite Service Provisioning mechanism in EC (CSP-EC) is proposed. It starts when the location of component service changes and terminates when the optimal composite service is obtained. CSP-EC employs dynamic optimization process to meet the real-time requirements. It first caches

m

optimized intermediate solutions from the first

m

users, which can be reused by other users to get the final optimal solution. Moreover, a multipopulation Estimation of Distribution Algorithm is used to reduce the probability of falling into a local optimum, and the roulette mechanism is used to accelerate the optimization process. Extensive simulations are conducted based on the real-world dataset. The results show that the proposed mechanism achieves higher quality, better stability, and shorter execution time compared with other schemes.
International Law Protection of Cross-Border Transmission of Personal Information Based on Cloud Computing and Big Data
Authors: Ziyi Xu
Published: August 2022

Cross-border data flow brings new growth and opportunities for the development of digital economy, but disordered cross-border data flow may damage national security, public interests, enterprise interests, and data sovereignty. At present, the unified rules for global regulation of cross-border data flow have not yet been formed. The existing rules are mainly led by developed countries like Europe and the United States. There is huge room for improvement in the international legal protection of cross-border transmission of personal information. This paper introduces the privacy protection mechanism of personal information data under the digital trade environment in China, that is, the privacy protection framework under the background of big data, cloud computing, and the cloud service selection method of data life cycle privacy protection. At the same time, we combined with many problems existing in the cross-border transmission of personal privacy information in China and compared with foreign advanced experience, and this paper puts forward China’s response path to clarify the obligations of data controllers and exporters, improve the responsibilities of regulators, improve the legislation of cross-border data flow, and improve the operability of the law; we vigorously carry out international cooperation and actively participate in the formulation of international rules, so as to further protect the rights and interests of personal privacy information protection.
Tim3scFv-Transforming Lactobacillus Inhibits Transplanted Tumor of Renal-Cell Carcinoma
Authors: Chen Zerong , Zhang Haibo , Hui Jialiang , Jiang Yaodong , Huang Zehai , Chen Zhuangfei , Zeng Weisen
Published: August 2022

Introduction: T-cell immunoglobulin-3 (Tim-3) antibody drugs can treat malignant renal tumors but are expensive. To overcome this limitation, Lactococcus lactis host bacteria were used to express Tim-3 single-chain antibodies. Methods: The pLAN-CTB-Tim3scFv plasmid was constructed using molecular cloning technology and transformed into Lactococcus lactis. Expression and immune activity of proteins in the transformed bacteria were analyzed using Western blotting and enzyme-linked immunosorbent assay in vitro. A mouse subcutaneously transplanted tumor model of renal adenocarcinoma was constructed. The promoting effect of transformed bacteria on mouse spleen lymphocyte activation and their inhibitory effect on transplanted tumors were analyzed. Results: Transformed L. lactis NZ-CTB-Tim3scFv and NZ-Tim3scFv were successfully constructed. CTB-Tim3scFv secreted by NZ-CTB-Tim3scFv showed immunological activity. Compared with the NZ-Tim3scFv and NZ-Vector groups, the subgroups of splenic lymphocytes in the NZ-CTB-Tim3scFv group had a higher proportion of CD3+CD4+, CD3+CD8a+, and CD3+CD69+ cells. Ki67 and CD31 expression in the NZ-CTB-Tim3scFv group was significantly reduced. Tumor volume in the NZ-CTB-Tim3scFv group increased the least. Discussion/Conclusion: Secretion of CTB-Tim3scFv promoted the proliferation and activation of spleen lymphocytes and inhibited growth, cell proliferation, and angiogenesis of tumors. The proposed method is low cost and convenient with potential to become a new immunotherapy approach for renal-cell carcinoma.
Multi-objective tasks scheduling using artificial bee colony algorithm based on cellular automata in cloud computing environment
Authors: Salehi Babadi Mehdi , Shiri Mohammad Ebrahim , Moazami Goudarzi Mohammad Reza , Haj Seyyed Javadi Hamid
Published: August 2022

Due to the development of communication device technology and the need to use up-to-date infrastructure ready to respond quickly and in a timely manner to computational needs, the competition for the use of processing resources is increasing nowadays. The scheduling tasks in the cloud computing environment have been remained a challenge to access a quick and efficient solution. In this paper, the aim is to present a new tactic for allocating the available processing resources based on the artificial bee colony (ABC) algorithm and cellular automata for solving the task scheduling problem in the cloud computing network. The results show the performance of the proposed method is better than its counterparts.
Comparing English and French for Business Coursebooks: a Cross-Cultural Discourse Analysis
Authors: Joseph Elaine Anderson
Published: August 2022

The focus of this article is to present the discipline Cross-Cultural Discourse Analysis and show how this approach was used in the analysis of business language coursebooks published in France and the United Kingdom. After presenting the foundations of this discipline, two areas of comparison will be explored. The first area concerns the representation of professional activity and examines how the work of women and men is represented differently in the coursebooks of both languages. The second area explores how the age of the characters contributes to the representation of a specific type of woman in the French coursebooks, while in the English coursebooks age serves to represent an opposition between youth and old age. These results are indicative of how a contrastive approach reveals certain aspects in the coursebooks of both languages that would otherwise go unnoticed in an analysis of a single set of coursebooks.
O ensino de argumentação na Argentina e no Brasil: aproximações e distanciamentos em diretrizes curriculares
Authors: Alves Lima Sheyla Fabrícia , Santos Yuri Andrei Batista
Published: August 2022

Considerando a demanda pela universalização da educação escolar nos países da região sul-americana, este trabalho tem por objetivo discutir como as diretrizes curriculares, na Argentina e no Brasil, propõem o desenvolvimento da argumentação no componente Língua Materna. Delineamos, então, uma análise de discursos comparativa que observa como cada cultura discursiva em destaque desenvolve suas percepções quanto ao ensino de argumentação. Nosso corpus centra-se nos eixos de trabalho com linguagens nos documentos de diretrizes curriculares para o ensino médio na Argentina, Núcleos de Aprendizagen Prioritarios, e no Brasil, Base Nacional Comum Curricular. Observamos que os discursos relacionados ao ensino de argumentação sugerem algumas aproximações quanto à ausência de uma base teórica para pensar o desenvolvimento desse conhecimento. Tal lacuna desdobra-se em semelhantes distanciamentos, no que tange à ausência de um ensino de argumentação concreto que ultrapasse as conformidades do desempenho em exames e avaliações externas.
Teaching and thinking Early Music in the 21st century: an interview with Walter Reiter
Authors: Held Marcus , Reiter Walter
Published: August 2022

In this interview granted to Marcus Held, Walter Reiter discourses on his ideas regarding the field of knowledge known as Early Music. Having witnessed and actively participated in the consolidation of this movement in the 1960's and the 1970's, the violinist, chamber musician, teacher and director talks about the challenges and the successes of teaching and thinking music from previous times in the contemporary world. Furthermore, he presents his recently published book, The Baroque Violin & Viola: a fifty-lesson course (Oxford University Press, 2020) and, in the end, narrates his experience of teaching Early Music in Cuba.
As Cirandas de Heitor Villa-Lobos: uma análise à luz das relações transtextuais de Gérard Genette
Authors: Wady Juliana
Published: August 2022

As Cirandas de Heitor Villa-Lobos são um conjunto de dezesseis pequenas peças caracterizadas pela citação de melodias do cancioneiro folclórico infantil brasileiro. Apesar da curta duração que apresentam, as Cirandas se tornaram um caso significativo no repertório pianístico villalobiano pela relação complexa e intricada que se interpõe entre a citação de cantigas folclóricas infantis e o entorno criativo que as envolve e modifica estrutural e simbolicamente. Procurar compreender toda esta relação dialógica que se manifesta inclusive no título, uma vez que o título de cada uma das Cirandas é o mesmo que o das respectivas cantigas citadas, é reconhecer os diversos textos musicais que se interlaçam e caminham por linhas tênues entre citação e criação. Assim, com objetivo de refletir e compreender estes vínculos o presente artigo pretende articular as Cirandas com o conceito de transtextualidade definido por Gérard Genette (1982) em sua obra intitulada Palimpsestes: La littérature au second degré, incidindo em três das cinco práticas transtextuais definidas pelo autor – paratextualidade, intertextualidade e hipertextualidade.
Música e interculturalidade: um estudo das relações entre a obra de Vilém Flusser e sua recepção
Authors: Castello Branco Marta
Published: August 2022

A obra de Vilém Flusser sobre música, escrita em português e alemão, fomenta uma abordagem não apenas bilíngue, mas antes intercultural acerca de seus temas e possíveis inter-relações. Em grande medida, a interculturalidade relativa às fontes primárias corresponde às estratégias de recepção incentivadas por seu arquivo sediado na Universidade das Artes em Berlim, que analisamos neste estudo de caso da obra sobre música e de suas particularidades. Analisamos a recepção de Flusser, seu contexto e o caráter da cooperação científica, que molda diretamente ferramentas e estratégias de investigação. Em nossa conclusão, apresentamos a importância da consideração de casos específicos de cooperação científica para a definição de possíveis ferramentas epistemológicas, especialmente em relação à música, assim como a observação detida de sua coerência com os objetos de estudo em questão.
Protective Role of Bone Marrow Mesenchymal Stem Cells (BMSCs) in Repairing Epithelial Cells of Diabetic Retinopathy
Authors: Ling Yu , Liang Haiming , Tang Qi
Published: August 2022

Diabetic retinopathy (DR) is one of the main causes of blindness. By directly employing mesenchymal stem cells to repair damaged retinal tissues, we aim to study the underlying repair mechanisms. 30 DR patients were included, along with 30 healthy control cases. Western-blot and qRT-PCR
were conducted to measure PI3K/Akt pathway-related genes. The PI3K/Akt antagonist (Rigosertib) was utilized in the induction process of cell differentiation to analyze the effects of PI3K/Akt pathwayspecific proteins and mRNAs. DR patients showed significantly elevated expression of PI3K/Akt
compared to control. With prolongation of induction, the expression of normal epithelial cell-related genes (SpC, SpB, SpA, CK18, KGF and Occludin) was elevated along with upregulated Occludin and KGF, two specific proteins of healthy epithelial cells. Meanwhile, the quantities of Occludin
and KGF in cell culture medium showed a gradual downward trend. In the differentiation of BMSCs towards epithelial cells, addition of PI3K/Akt antagonist Rigosertib was negatively correlated with the expression of several genes (IGF-1, shh, EGF, mTOR, AKT and PI3K) and decreased the quantities
of PI3K/Akt pathway-specific proteins (mTOR, PI3K and AKT). In conclusion, BMSCs can effectively reduce the release of cytokines in DR and promote the repair of damaged diabetic retina, possibly through regulation of PI3K/Akt signaling pathway.
Identification of Four Hub Genes as Promising Biomarkers for the Evaluation of Ovarian Cancer Prognosis
Authors: Tan Li , Liu Xiaoting , Gao Wei , Zhao Qiong
Published: August 2022

Ovarian malignant growth is perhaps the most lethal disease in females. There are no exact biomarkers for the early determination of ovarian disease. We obtained a total of 12 gene clusters through WGCNA and studied the azure gene modules related to the lymphatic infiltration of ovarian
cancer further. What’s more, endurance investigation was utilized to decide three qualities connected with the by and large and infection-free endurance in ovarian disease patients, including GOGA8B [Hazard Ratio (HR)=1.53, p=0.037, 95% CI: 1.05–2.24], LRRC26
(HR=0.7, p =0.045, 95% CI: 0.48–1.01), and CCDC114 (HR = 0.72, p = 0.042, 95% CI: 0.53–0.98). A prognostic risk score model was built to anticipate the endurance pace of patients at 1, 3, and 5 years, individually. The area under the receiver operating characteristic
(ROC) curve (AUC) of the training set was 0.749, 0.764, and 0.784, respectively; the test AUC was 0.601, 0.623, and 0.709. Our review gives a point of view on significant possible biomarkers for the determination, anticipation, and therapy of ovarian malignant growth.