bluuebunny/crossref_metadata_2025 huggingface dataset:
TIC e IA, el futuro de la educación: mejorando el acceso y la efectividad del aprendizaje
Authors: Ramírez Ochoa Dynhora Danheyda , Villagran Vizcarra Dafnis Cain , Trevizo Zamarrón Vianney
Published: January 2025

El proceso de búsqueda para la presente investigación consistió en definir palabras clave y utilizar bases de datos académicas como IEEE Xplore y Google Scholar. Se seleccionaron estudios publicados entre los años 2010 y 2024 en inglés y español, basados en criterios de inclusión y exclusión, excluyendo artículos de opinión que carecieran de datos empíricos. Se revisaron los títulos y resúmenes para identificar estudios relevantes, los cuales fueron evaluados según sus métodos, resultados y conclusiones. El análisis organizó la información en categorías temáticas, comparando los hallazgos para identificar patrones y diferencias. Una evaluación crítica destacó las fortalezas y limitaciones de los estudios revisados y propuso direcciones para futuras investigaciones. Este artículo investiga la intersección entre las TIC y la IA en la educación, analizando su impacto en el acceso a la información, el aprendizaje personalizado y el desarrollo de habilidades del siglo XXI. También aborda desafíos como la brecha digital y la formación docente, presentando casos de éxito como los entornos virtuales de la Universidad de Stanford y el sistema de IA ‘Pounce’ de la Universidad Estatal de Georgia. Este análisis proporciona un marco para discutir la evolución de la educación en la era digital y sugiere direcciones para futuras investigaciones.
Adolescents, Complex Trauma, and Making Meaning Through Art
Authors:   , Grame Teresa
Published: January 2025

This qualitative study generated new knowledge and deepened understanding of how adolescent survivors make meaning of trauma recovery through art. Narrative inquiry methods applied art making with adolescent survivors of complex trauma who used art to express their experiences of healing. Eleven adolescents, ages 13-18, created three separate pieces of art representing how they see themselves and the world, in the past, present, and future. Narrative themes came alive through art in the form of metanarratives and storylines based on analysis of the formal elements of art and the Expressive Therapies Continuum. Art elements and art materials gave voice to the personal meaning of lived experience through the eyes of survivors. Art was a novel and effective method for participants to express their views of self and the world. Participants recognized their growth through art and generated hope for themselves and other survivors. Art honored the agency of adolescents and their capacity to reflect on and define what helps their trauma recovery. The artwork created by participants contains valuable direction about how practitioners and researchers can meaningfully support adolescent survivors using art intervention by focusing on trauma recovery.
Parentés électives. Figures et pratiques de la filiation en histoire de l’art
Authors: Cornali Lisa , Fuchs Cyprien
Published: January 2025

Dans sa biographie de Piero di Cosimo, Giorgio Vasari nous apprend que le peintre florentin, fils d’un orfèvre nommé Lorenzo, était élève de Cosimo Rosselli « dont il porta toujours le nom, parce qu’il regardait plutôt comme son véritable père celui qui avait procuré l’indépendance et le talent, par ses leçons, que celui dont il n’avait reçu que la vie ». Aux liens du sang, Piero préfère donc une filiation artistique et l’égide d’un maître. Par cette substitution, il se présente en héritier d’un illustre prédécesseur et valorise son propre travail.
À l’instar de Piero di Cosimo, nombre d’artistes se choisissent des figures tutélaires – ou désignent des disciples – dans un objectif d’autopromotion ou de légitimation. Les historiennes et historiens de l’art comme les critiques établissent également des parentés artistiques pour saisir ou construire les rapports de proximité entre personnalités créatrices ou entre mouvances plus larges. Omniprésente en histoire de l’art, la notion de filiation n’a pourtant jamais fait l’objet d’un examen terminologique. À travers l’Europe, du Moyen Âge au XXe siècle, au croisement d’une multitude de techniques – peinture, sculpture, architecture, gravure, dessin, enluminure, orfèvrerie –, les textes rassemblés ici étudient les figures et les pratiques de la filiation artistique. Cet ouvrage initie ainsi une réflexion sur le sens et les enjeux de ces parentés électives.
Analisis Rugi Daya pada Saluran Transmisi Antara Gardu Induk Aur Duri Ke Jurusan Payo Selincah
Authors: Marseila Marseila , Dewi Rozlinda , Suprapto Eko
Published: January 2025

During the distribution of electric power, there are power losses which occur in both the line and the transformer. Power loss can be identified if the voltage at the transmitting base (generator) and the receiving base is different from research data. Power loss is energy loss that cannot be avoided. It is important to anticipate and examine energy loss in order to ensure it stays within acceptable boundaries. A lack of electricity supply in an area will result in low voltage, even power outages. The voltage and current at peak load every day are taken at 14.00 WIB and 22.00 WIB. The distance from the Aur Duri substation to the Payo route is 19 km, as this transmission line enters the short transmission line. The power losses that occur when sending power from G.I Aurduri to the Payo Selincah department are quite large. However, these losses still meet the requirements for the feasibility of transmission lines according to PUIL PT. PLN (Persero) 2010, namely not more than 10%. The cause of power loss is due to several factors, namely insulator leaks, long distances, environmental temperature, lack of current flowing and the conductor table material used.
Optimalisasi Restorative Justice Sebagai Bentuk Perlindungan Hukum Terhadap Anak Yang Berhadapan Dengan Hukum di Polda Jambi
Authors: Irawan Agus , Ternando Albi , Kurniawan Ridha
Published: January 2025

Restorative Justice is expected to be one of the ways or alternatives to handle crimes or crimes that prioritize the restoration of the balance of the relationship between the perpetrator of the crime and the victim Protection for children who are facing the law is the prerogative of children. The research approach used in this study is the method This research is empirical legal research, The internal factor faced by the Jambi Police in the implementation of restorative justice for children is the lack of time given by law because of the law The invitation only gives a deadline of 30 days, the time is very short, considering that in summoning witnesses and victims it is also quite difficult because they are not necessarily present at the specified time, which hinders investigators in their examination efforts, and sub-directorate IV of the Renakta and the Vulnerable group room still lack skilled and educated investigator personnel in handling children's cases, there is only one investigator who has special expertise as a child investigator. External factors include the factor of the child who is dealing with the law of the child as the perpetrator who commits the crime in the examination still seems afraid to provide information related to the criminal act committed, the factor of the victim and the victim reporter and the complainant does not want to forgive the child who are facing the law and do not want to be resolved through restorative justice.
Problems of risk management in the era of digital transformation
Authors: Klymenko Svetlana
Published: January 2025

The relevance of the topic is determined by the study of the impact of the processes of digitalization of economic relations on the peculiarities of the organization of the enterprise’s risk management system. It is known that digitalization is accompanied by the emergence of new system-wide types of risks determined by the digital transformation of business processes. Determined the economic meaning of digitization in today’s conditions and its impact on the construction of modern enterprise risk management. The influence of the main processes of development of digital technologies on the corresponding structural and functional components of the risk management systems of organizations is analyzed. The main types of risks associated with digitalization are identified: strategic, regulatory, technological, cyber, personnel risks, risks of data loss, confidentiality, and third party risks. Management measures for the minimization of these risks have been identified.
The main approaches to the creation of a modern risk management system in organizations are considered and the expediency of introducing digital mechanisms into the risk management structure to increase the efficiency of its work is substantiated. Modern risk management models of the company must extend internal control over the expected results in order to guarantee the achievement of the planned goals of the organization.
Current models of risk management do not sufficiently reflect the current dynamics of changes in the external environment and processes that occur in all subsystems of the company’s management and fragmentarily reflect the information necessary for making adequate management decisions. The article substantiates the expediency of introducing digital mechanisms into the structure of risk management to increase the efficiency of its work.
Based on the fact that digitalization is an inevitable change that is already happening in all areas of business, the main critical fields of risks and threats are outlined: data security, transformation of business processes, reliability of digital systems and infrastructure.
Ways of optimizing public debt management in Ukraine
Authors: Kulyk Yuliia , Doloka Liudmyla , Poliakh Serhii
Published: January 2025

The article shows that as a result of the decrease in business activity, the loss of many people’s jobs and means of livelihood, the beginning of a full-scale war on the territory of the country, and the need for active actions on the part of authorities and management at various levels regarding the defense of the country, maintaining an acceptable standard of living and ensuring the necessary minimum support of the population, colossal losses of the revenue part of the budget, all this has a significant impact on the size and structure of state borrowing.
The work examined the essence of the state debt based on the research of various domestic scientists. It is proposed to consider this concept from two points of view: economic and material. The paper structured the classification of the state debt according to certain classification features and considered the state debt management system. The dynamics of the state debt of Ukraine from 2011 to the 1st quarter of 2022 shows a growth of 651 % for the entire period. The main years with a significant increase in the state debt are 2014 — 188.4 %, 2015 — 122.8 % and 2022 — 115 %. In the work, considerable attention is paid to revealing the structure of the state debt of Ukraine for the analyzed period. The authors analyzed the main social components of state borrowing, identified the main sources of financing the state debt of Ukraine and the main reasons for its growth. It has been studied that under the current management system, the state debt may reach 92.3 % of the country’s GDP by 2027. A significant reduction in the country’s GDP, an increase in the state budget deficit necessitates new borrowing and makes it impossible to fully repay and service the state and state-guaranteed debt in the future. It was emphasized and substantiated that to improve the situation with the state debt, first of all, an effective post-war management strategy is necessary, and the best option may be the restructuring of Ukraine’s debt.
Implementation of OECD measures on combating tax avoidance: EU experience
Authors: Oliinyk Yana , Kryshtopa Iryna , Nikolenko Larysa , Vorobeу Svitlana
Published: January 2025

The draft directive, known as ATAD III, aims to prevent the use of transit companies for tax evasion and avoidance, and has a potential impact on investment funds that currently benefit from EU tax directives and agreements.
The provisions of the proposed Directive will be applicable to any enterprise that is considered a tax resident or has the right to obtain a certificate of tax residence in an EU member state, regardless of its organizational and legal form. The targets are businesses that have no real economic activity and are used solely for tax avoidance and evasion and allow their beneficial owners or group to obtain tax benefits.
ATAD III aims to introduce a single EU-wide test for determining whether a company is a transit company for tax purposes, the minimum criteria of which are essentially the following: having its own office premises or premises for exclusive use in the relevant EU Member State; holding at least one active bank account in the EU; the presence of a local director who deals exclusively with this group and/or employees who work full-time and live in close proximity to its activities.
Given the desire of the EU legislator for ATAD III to enter into force fairly quickly, and that the current control period has already started on 1 January 2022, companies potentially subject to ATAD III need to urgently assess the impact of ATAD III on their group structure and make changes where appropriate.
Export potential of agricultural products of Ukraine in the conditions of war: challenges and opportunities
Authors: Yakimchuk Vitalii , Chukhraieva Nataliia
Published: January 2025

Ukraine is the largest country in Europe by area. And one of the main players in the world market of agricultural products, for which it received the nickname «The Granary of Europe». This is caused by the geographical and climatic conditions of the state. The largest areas of chernozems — fertile soils that are ideal for growing agricultural products — are concentrated here. Agriculture employs 13 million Ukrainians and 55 % of the country’s area. In 2022, the Russian Federation, which is the main competitor of Ukraine on the global agricultural market, started a full-scale war against Ukraine.
This caused structural changes in both local and global markets. The article examines economic transformations in the agricultural sector of Ukraine, in the process of its adaptation to changes in the modern world market and challenges related to the war unleashed by the Russian Federation. The strengths and weaknesses of the export potential of agricultural products of Ukraine are analyzed, the analysis is given, the state and international programs aimed at improving the agricultural sector and its export potential are considered. The role and place of Ukrainian agricultural products in the world market and ways of its further development are analyzed. Examines government efforts to create and develop modern, high-value-added agricultural sectors such as greenhouses and horticulture, and their role in postwar agricultural development. The value of the study is the consolidation of information about structural changes in all branches of agribusiness during the period of active military operations, namely the selection of crops for cultivation, fertilizing, logistics, storage, sale on the domestic market and export of grown products to the world market.
Quantum Power Plant
Authors:   Certified Engineer, Tehran, Iran, Khalesi Elham
Published: January 2025

In this paper, it will be tried to propose a new theory for producing energy from quantum o electricity
The Reactivation of Tissue Trophism and Vascular RegEneration, even on Damaged Skin and During Inflammatory Processes, by Mixture of Unsaponifiable Fractions of Vegetable Oils and Pollen-Clinical Cases
Authors:   International Wound Care Specialist, University of TorVergataSapienza, Pol.Gemelli.Cattolica, Silvestrini Prof. Sonia , Mosca Prof. Nella ,   International Wound Care Specialist, University of TorVergataSapienza, Pol.Gemelli.Cattolica, Baraldi Christian ,   International Vascular Surgeon, Medical Center Director Lamezia Terme
Published: January 2025

The mixture of unsaponifiable fractions of vegetable oils and
pollen, with an oily consistency, promotes the regeneration of the
circulation and tissue trophism, being keratoplastic, hydrating and
a powerful anti-aging agent, reactivating and re-establishing skin
trophism [1].
Digital Technology to Support Sustainable Development Goals (SDGs): Literature Review
Authors: Ariansyah Ariansyah , Prayogi Saiful , Kurnia Nova , Bilad Muhammad Roil , Sutarto Sutarto
Published: January 2025

Digital technology is a critical enabler in achieving Sustainable Development Goals (SDGs) by enhancing efficiency, transparency, and inclusivity across sectors such as education, health, economy, and the environment. This study employs a Narrative Literature Review (NLR) approach to explore the role of technologies like artificial intelligence (AI), the Internet of Things (IoT), and blockchain in advancing SDG targets. The research identifies opportunities for these technologies to improve service delivery, foster innovation, and mitigate challenges like unequal access, cybersecurity risks, and ethical concerns. The literature search covered journal articles, books, and reports from academic databases, focusing on keywords related to digital technologies and the SDGs. An analysis framework was applied to synthesize findings across diverse sectors. Results indicate that AI and IoT drive efficiency in education and healthcare, while blockchain enhances financial inclusivity and sustainable urban planning. However, disparities in digital access and ethical issues, such as data privacy, remain substantial obstacles. This review provides actionable insights for policymakers and stakeholders to leverage digital tools effectively for inclusive and sustainable development. Emphasizing multisectoral collaboration, the study underscores the importance of ethical frameworks and inclusive digital infrastructure to maximize technological benefits. These findings contribute to the broader understanding of digital technology’s integrative impact on sustainable development, offering strategic recommendations for future research and implementation.
Identifikasi Miskonsepsi Peserta Didik SMA Melalui Tes Diagnostik Four-Tier pada Hukum Newton
Authors: Silaban Bajongga , Surbakti Mariana Br , Silaban Irving Josafat Alexander , Purba Jusbinaraya
Published: January 2025

Penelitian ini bertujuan untuk: 1) mengembangkan tes diagnostik Four-Tier, 2) mengidentifikasi tingkat miskonsepsi peserta didik, dan 3) menjelaskan faktor-faktor penyebab miskonsepsi pada hukum hukum Newton. Jenis penelitian yang digunakan adalah penelitian pengembangan model Tessmer, dengan terlebih dahulu memvalidasi tes diagnostik Four-Tier tersebut kepada expert review (dosen dan guru ) fisika. Selanjutnya dilakukan uji coba skala kecil pada peserta didik kelas 10 fase-E SMA Batara School Medan sebanyak 13 orang. Setelah dilakukan revisi terhadap hasil uji coba tersebut, selanjutnya dilaksanakan ujicoba skala besar pada peserta didik kelas X fase-E SMA Nasrani 1 Medan sebanyak 23 orang yang tersebar secara heterogen dan penarikan sampel dilakukan  dengan purposive sampling. Hasil tes diagnostik peserta didik dikelompokkan pada 3 kategori, yaitu paham konsep, miskonsepsi, dan tidak paham konsep. Berdasarkan hasil penelitian, rata-rata miskonsepsi peserta didik yang diperoleh sebesar 61,10%. Miskonsepsi paling tinggi terdapat pada konsep gaya berat yakni sebesar 86,36% di mana peserta didik sulit membedakan kosep massa dengan berat. Rata-rata miskonsepsi dalam memahami konsep hukum-hukum Newton dan penerapannya masing-masing 62,98% dan 52,35% tergolong cukup tinggi. Disimpulkan bahwa dengan menggunakan tes diagnostik Four-Tier dapat digunakan untuk mengukur tingkat miskonsepsi peserta didik lebih akurat.
Bullying escolar e o sistema legal brasileiro: Uma história de desafios e avanços legislativos
Authors: Silva Elane Moraes da , Nascimento Mineia Amorim , Barros Ana Alice Farias de , Pedroso Andreza Cristiana da Silva , Oliveira Kathleen Tavares de , Nunes Sanderly Dacio , Sena Tatiane Gonçalves Rebelo Andrade de , Cordeiro Karolina Maria de Araújo , Vieira Kênia Neto , Silva Ellen de Moraes e
Published: January 2025

Este estudo tem como objetivo analisar a evolução histórica das legislações brasileiras que tratam do bullying no contexto escolar, destacando a relação dessas normativas com os direitos das crianças e adolescentes. A questão que norteou a investigação foi: como as legislações brasileiras abordaram e evoluíram no combate ao bullying nas escolas ao longo do tempo? A metodologia adotada foi qualitativa e descritiva, com base em uma revisão bibliográfica e documental. A pesquisa envolveu a análise de fontes primárias e secundárias, incluindo legislações e outras normativas educacionais. Além disso, foram examinados tratados internacionais. Os resultados encontrados revelaram uma evolução gradual das legislações brasileiras no combate ao bullying escolar, com destaque para o fortalecimento das políticas públicas e a criação de marcos legais, como a Lei nº 14.811/2024, que criminaliza o bullying e o cyberbullying. A pesquisa contribui para a compreensão da importância da legislação como ferramenta para promover um ambiente escolar seguro e inclusivo.
Equivalência entre a taxa de filtração glomerular e a fórmula CKD-EPI: Um protocolo de revisão de escopo
Authors: Gomes Cecília Neta Alves Pegado , Oliveira Laura Pires Soares de , Oliveira Anna Lívia Cunha de , Fernandes Maria Júlia Vasconcelos , Gomes Sophia Alves Pegado Cavalcante , Maia Alice de Oliveira , Diniz Ennio Javi Siqueira Barbosa , Viana George Baracuhy Cruz , Lucena Laís Schuler de , Magalhães Larissa Santos , Ciraulo Matheus Felipe de Moura , Alencar Ruana Tâmara Barbosa de , Batista Sarah Carolyne Santos
Published: January 2025

Objetivo: Apresentar um protocolo de revisão de escopo para identificar e organizar as evidências disponíveis sobre a equivalência entre a medida de taxa de filtração glomerular e a fórmula CKD-EPI para sua estimativa. Métodos: Trata-se de um protocolo de revisão de escopo elaborado conforme as diretrizes PRISMA-P para relatos de protocolos de revisão. A busca foi realizada nos bancos de dados: Lilacs, Scielo, Pubmed, Cochrane Library e CAPES periódicos. Doze revisores independentes rastrearam os artigos pelo título e resumo. Em seguida, foi feita a leitura do texto completo dos artigos incluídos, considerando os critérios de elegibilidade. Resultados e Discussão: A função renal é frequentemente avaliada por meio de fórmulas baseadas na creatinina sérica, como as equações CKD-EPI e MDRD-4, devido à dificuldade e custo das medições diretas, como a depuração de inulina. A fórmula CKD-EPI é considerada mais precisa e foi recomendada nas diretrizes KDIGO de 2024, demonstrando boa correlação com a taxa de clearance de creatinina (ClCr), embora ainda haja uma superestimação da TFG devido à secreção de creatinina nos capilares peritubulares. Estudos sugerem que a CKD-EPI tem melhor desempenho na estimativa da TFG em comparação com a MDRD-4, especialmente em estágios iniciais da doença renal crônica (DRC), mas em estágios avançados, a MDRD-4 pode ser mais adequada. A fórmula CKD-EPI também foi validada em diferentes populações, incluindo a coreana, demonstrando sua aplicabilidade global. A utilização dessas equações é fundamental para a estratificação da DRC, influenciando a abordagem terapêutica e a prevenção de complicações, o que destaca a importância de estudos que avaliem a precisão dessas fórmulas na estimativa da TFG. Conclusão: Sob esta ótica, este protocolo de revisão de escopo apresenta o atual panorama das pesquisas sobre o tema, identificando os hiatos existentes na base de evidências.
Acreditação em saúde: Revisão sistemática para avaliação da acreditação AAHRPP
Authors: Lira Neto Roberto Eider , Hékis Hélio Roberto , Almeida Mariana Rodrigues de , Carvalho Iago Tavares de
Published: January 2025

A pesquisa utilizou a metodologia PRISMA 2020 para realizar uma revisão sistemática sobre a importância da acreditação AAHRPP (Association for the Accreditation of Human Research Protection Programs) em centros de pesquisa clínica. A investigação revisou e sintetizou evidências para avaliar como a acreditação da AAHRPP influencia a qualidade, segurança e eficácia das pesquisas clínicas. Este estudo tem o objetivo de explorar a importância dos processos de acreditação nesses centros, destacando como práticas padronizadas e rigorosas de avaliação melhoram o atendimento e a condução de ensaios clínicos. Os resultados destacam que a acreditação AAHRPP promove a adoção de padrões rigorosos de proteção aos participantes de estudos, padroniza processos e procedimentos em instituições de pesquisa, aumenta a credibilidade das instituições acreditadas e facilita a colaboração internacional. Além disso, a acreditação AAHRPP contribui para a melhoria contínua dos programas de proteção à pesquisa, sendo essencial para garantir a conformidade regulatória e a ética na condução de estudos clínicos.
Humpback whale densities are increasing in the Great South Channel: concurrent multi-trophic level shifts in abundance
Authors: Roberts SM , Dowd S , Thorne L , Roberts JJ , Halpin PN , Khan C , Palka D , Wiley D , Smith LA , Smith BE , Nye JA
Published: January 2025

Humpback whale Megaptera novaeangliae populations have exhibited higher local abundance in parts of the Gulf of Maine in recent years, a region that is heavily impacted by both climate change and other anthropogenic effects. The Gulf of Maine is one of the most rapidly warming ecosystems in the ocean, and humpback whales use the region to feed, suggesting that there may be interactions between humpback whales, climate, and prey species in this region. We sought to understand how humpback whale densities and distributions are changing in this area in the context of prey and the environment, focusing on a particular conservation area with ample survey coverage, the Great South Channel Habitat Management Area. We used data from 16 yr of overlapping humpback whale, fish, and invertebrate surveys to relate changing humpback whale densities to environmental covariates as well as fish and invertebrate biomass. We found that humpback whale densities are increasing in the Great South Channel faster than in the surrounding area, and these increases are related to increasing biomass of squid, small gadids, and crabs and lobsters; warming temperatures; and decreasing salinity. Sand lance and herring, 2 common humpback whale prey species, decreased in this area during the study period. These interactions between humpback whales, temperature, and fish and invertebrate species could signify that increases in humpback densities are related to both biotic and abiotic variables and suggests that this conservation area may be effective at promoting the biomass of a variety of trophic levels.
Sevastopol school of algotechnology
Authors: Trenkenshu Rudolf P. , Lelekov Alexander S.
Published: January 2025

The article focuses on the twenty-fifth anniversary of the Department of Biotechnology and Phytoresources creation in A.O. Kovalevsky Institute of Biology of the Southern Seas of RAS. On this base the scientific school of algotechnology was formed in Sevastopol hero-sity. The main achievements of modern science in the field of microalgae growth research at the cellular and population level of organization are briefly outlined. Special attention is paid to scientific directions, which in their totality touch practically all issues of algotechnology. The fundamental theme of the school is represented by five points: study of energy and mass exchange of microalgae in culture; modelling of dynamics of biosynthesis, respiration and substrate-dependent growth of microalgae; theoretical bases of biochemical composition microalgae’s biomass control; role of mixotrophic type of nutrition in production processes and environment reclamation; anhydrobiosis and halobiosis as a way of microalgae survival. Practical significance of the conducted research is conditioned by the development of the system of control and management of microalgae culture growth, ordering and processing of information about promising objects of algotechnology, approaches and methods of optimization of industrial cultivation of microalgae, obtaining biomass of a given biochemical composition, as well as technologies of biological pretreatment of waste water. The main monographs and dissertations that form the basis of each direction are given.
Hubungan Dukungan Keluarga dan Efikasi Diri dengan Kepatuhan Minum Obat Anti Tuberkulosis (OAT) pada Pasien TB Paru di Puskesmas Kabupaten Situbondo
Authors: Rahman Handono Fatkhur , Widad Sofil , Sholehah Baitus
Published: January 2025

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, primarily affecting the lungs and leading to significant health challenges. In 2021, 450,000 cases of multidrug-resistant tuberculosis (MDR-TB) were reported, marking a 3.1% increase from the previous year. Family support plays a vital role in motivating patients to adhere to treatment regimens, while high self-efficacy boosts patients' confidence in completing therapy. Adherence to tuberculosis treatment is defined as completing a six-month course of therapy without interruptions. This study aimed to analyze the relationship between family support, self-efficacy, and adherence to anti-tuberculosis medication (OAT) among pulmonary TB patients in Situbondo District. A cross-sectional design was employed, involving 112 respondents selected through Slovin's formula from a population of 156 TB patients at Besuki and Panji Health Centers. Data collection utilized validated questionnaires on family support, self-efficacy, and medication adherence, analyzed using the Spearman test. Results revealed a significant relationship between family support and adherence (p=0.000; r=0.443) and between self-efficacy and adherence (p=0.000; r=0.537). The study concludes that both family support and self-efficacy are crucial factors influencing adherence to tuberculosis treatment among pulmonary TB patients in Situbondo.
FiberO for an automated quantitative analysis of fibers orientation and organization in biological fibrous tissues
Authors: Muñoz Asier , Docaj Anxhela , Fernandez Julen , Carriero Alessandra
Published: January 2025

Many biological fibrous tissues exhibit distinctive mechanical properties arising from their highly organized fibrous structure. In disease conditions, alterations in the primary components of these fibers, such as type I collagen molecules in bone, tendons, and ligaments, assembly into a disorganized fibers architecture generating a weak and/or brittle material. Being able to quantitatively assess the fibers orientation and organization in biological tissue may help improve our understanding of their contribution to the tissue and organ mechanical integrity, and assess disease progress and therapy effect. In this work, we present FiberO, a new open-source available software that automatically quantifies fibers orientation, by performing morphological image openings, and fibers organization within the tissue, by determining and plotting their continuity in groups. FiberO performance is here evaluated using second harmonic generation microscopy images of mouse bones and tendons as examples of biological fibrous tissues. FiberO outperformed Directionality and OrientationJ, two open-source plugins available in ImageJ, and FiberFit and CT-FIRE, in the calculation and plotting of fibers orientation in reference images with known fibers orientation. Additionally, FiberO is currently the sole software to date able to accurately track the continuity of aligned fibers, and it quantifies and displays the organized surface(s) in the tissue of interest. FiberO can be used in the wider engineering and science field to investigate the fibers orientation and organization of different natural and synthetic fibrous tissues.
Evaluation of 2,3-butanediol derived from whey fermentation as an effective bio-based monomer for waterborne polyurethane dispersions
Authors: Germán-Ayuso Lorena , Cobos Rubén , Lorenzo Leire , Río Francisca , Prieto-Fernández Soraya , Roncal Tomás , Cuevas José M.
Published: January 2025

Within the context of the circular economy, the transformation of agri-food waste or by-products into valuable products is essential to promoting a transition towards more sustainable and efficient utilisation of resources. Whey is a very abundant by-product of dairy manufacturing. Apart from partial reutilisation in animal feed or some food supplements, the sustainable management and disposal of whey still represent significant environmental challenges. In this work, whey is considered a valuable resource for producing high-value products, specifically 2,3-butanediol (2,3-BDO), which was produced through fermentation using the bacterial strain Lactococcus lactis 43103. The described process yielded a >90% purity of 2,3-BDO, which was evaluated as a potential chain extender in the synthesis of bio-based waterborne polyurethane dispersions (PUDs). The incorporation of whey-derived 2,3-BDO led to the development of PUDs with up to 90% bio-based content without detrimental effects on the process or liquid-phase properties. The combination of 100% bio-based polyether polyols with partially renewable L-lysine ethyl ester diisocyanate and whey-derived 2,3-BDO as a chain extender generated totally stable, low-particle-size water dispersions of amorphous polymers characterised by similar structure and molecular weight compared to those of alternative petroleum-based PUDs. These results open up the possibility of incorporating fermentation-derived 2,3-BDO as a totally renewable component in bio-based PUDs as potential sustainable resinous systems for further formulation of water-based coatings or adhesives.
Plasmodium falciparum transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance
Authors: Shi Qiyang , Wang Changhong , Yang Wenluan , Ma Xiaoqin , Tang Jianxia , Zhang Jiayao , Zhu Guoding , Wang Yinlong , Liu Yaobao , He Xiaoqin
Published: January 2025

Introduction

A continuing challenge for malaria control is the ability of Plasmodium falciparum to develop resistance to antimalarial drugs. Members within the Plasmodium transcription factor family AP2 regulate the growth and development of the parasite, and are also thought to be involved in unclear aspects of drug resistance. Here we screened for single nucleotide polymorphisms (SNPs) within the AP2 family and identified 6 non-synonymous mutations within AP2-06B (PF3D7_0613800), with allele frequencies greater than 0.05. One mutation, K3124R, was located in a PfAP2-06B AP2 domain.

Methods

To investigate transcriptional regulation by PfAP2-06B, ChIP-seq assays were performed on 3D7/PfAP2-06B-GFP schizonts using antibodies against GFP. The DNA sequences of the artemisinin-resistant CWX and the quinoline-resistant strains PfDd2 and Pf7G8 were analyzed for the genetic diversity of AP2-06B, compared with the Pf3D7 strain as a reference sequence. To determine whether AP2-06B can alter the expression of pfk13 and pfcrt, as well as cause artemisinin and quinoline resistance in Plasmodium, we generated both a K3124R mutation and conditional knockdown of AP2-06B in Pf3D7 using CRISPR/Cas9-mediated genome editing.

Results

ChIP-Seq analysis showed that AP2-06B can bind to the loci of the Plasmodium genes pfk13 and pfcrt. The AP2-06B K3124R mutation was also found in the artemisinin-resistant parasite strain CWX and the chloroquine-resistant strains Dd2 and 7G8. Contrary to expectation, Pf3D7 Plasmodium lines modified by either K3124R mutation of AP2-06B or conditional knockdown of AP2-06B did not have altered sensitivity to artemisinin or quinolines by modulating pfk13 or pfcrt expression.

Discussion

AP2-06B was predicted to be associated with artemisinin and quinoline resistance, but no change in resistance was observed after mutation or conditional knockdown. Given the multigenic nature of resistance, it might be difficult to recreate a resistance phenotype. In conclusion, whether AP2-06B regulates the development of artemisinin or quinoline resistance remains to be studied.
A case for characterizing declarative memory commission errors in healthy aging
Authors: Popoviciu Ariana , Richmond Lauren L.
Published: January 2025

Cognitive psychologists typically characterize declarative memory performance in terms of omission errors, or information that is not reported at test. At the same time, there tends to be much less attention paid to characterizing errors of commission, such as reporting non-studied items at test. Importantly, older adults are known to make both types of errors in declarative memory tasks more often than young adults. This review aims to encourage a more thorough characterization of age-related commission errors in declarative memory research by synthesizing findings from disparate literatures that have taken an interest in characterizing this type of error. Specifically, findings relating to commission errors from the false memory, associative memory, and hyper-binding literatures are reviewed to demonstrate the utility of characterizing older adults' declarative memory performance by accounting for commission errors. Together, existing cognitive data provide a compelling rationale for memory researchers, and particularly those interested in age-related changes in memory, to characterize performance by accounting for commission errors in addition to the more commonly considered omission errors.
The correlation and predictive value of Hb, RDW and their association for short-term and long-term mortality in patients with acute aortic dissection
Authors: Hou Peng , Xia Lin , Xin Fangran , Sun Boxuan , Zhang Guoxin , Yu Liming , Wang Huishan
Published: January 2025

Background

This study examines the relationship between Hb, RDW and their association and both short-term and long-term mortality in patients with acute aortic dissection (AAD), aiming to establish combined effect between Hb and RDW as a potential prognostic biomarker for AAD outcomes.

Methods

We extracted clinical data from the Medical Information Mart for Intensive Care (MIMIC) databases for this analysis. Using adjusted Cox regression and Kaplan-Meier survival curve analyses, we assessed the relationship between Hb, RDW and their association at admission and mortality at multiple post-discharge intervals (30 days, 90 days, 1 year, and 5 years) among patients with AAD. Additionally, subgroup analyses and receiver operating characteristic (ROC) curve analyses were conducted to evaluate the predictive accuracy of Hb, RDW and their association for mortality in this patient population.

Results

High RDW combined with low Hb (RDW ≥ 13.60 and Hb < 7.9) significantly predicted increased mortality at 30 days, 90 days, 1 year, and 5 years post-diagnosis, with hazard ratios (HRs) as follows: 4.33 (95% CI: 1.82–10.33, P < 0.001), 4.48 (95% CI: 2.06–9.77, P < 0.001), 3.38 (95% CI: 1.70–6.70, P < 0.001), and 3.07 (95% CI: 1.66–5.66, P < 0.001), respectively.

Conclusion

Hb and RDW are both abnormal (Hb with low level, RDW with high level) is positively correlated with 30 days, 90 days, 1 year, and 5 years mortality risk in patients with AAD. This suggests that combined effect between Hb and RDW is a significant predictor of short-term to long-term mortality risk in this patient population, highlighting its potential utility as a prognostic marker in clinical settings.
Clinical profile of an unselected population with heart failure treated with vericiguat in real life: differences with the VICTORIA trial
Authors: Esteban-Fernández Alberto , Recio-Mayoral Alejandro , López-Vilella Raquel , de Lara Gregorio , Barrantes-Castillo Moisés , Gómez-Otero Inés , Nuñez-Villota Julio , Robles-Gamboa Carolina , López-Aguilera José , Iniesta-Manjavacas Ángel , Fluviá Paula , Pastor-Pérez Francisco , Belarte-Tornero Laia , Alonso-Salinas Gonzalo , Díez-Villanueva Pablo
Published: January 2025

Introduction

Vericiguat, an oral stimulator of soluble guanylate cyclase, reduces cardiovascular mortality and hospitalisations in patients with heart failure (HF) and reduced ejection fraction, as demonstrated in the VICTORIA trial. This study assessed the real-world use of vericiguat.

Material and methods

This cross-sectional, prospective and multicenter registry (VERISEC) included 776 patients from 43 centres in Spain between December 2022 and October 2023. Of these patients, 79.6% were male, with a mean age of 72.4 (SD:8.7) years. Patients in VERISEC were older and had more comorbidities (diabetes, advanced chronic kidney disease) compared to VICTORIA, with 20% having an estimated glomerular filtration rate below 30 ml/min. They also had higher natriuretic peptide levels [NT-proBNP: 3551 (IQR: 1,675.9, 7,054.0)] pg/ml. Most patients (79.8%) started vericiguat after HF decompensation within the previous three months, with high use of loop diuretics (with an average dose of 65 mg/day) and implanted devices (50%). Sixty percent of patients were on quadruple therapy, with a higher use of sodium-glucose co-transporter 2 inhibitors compared to the VICTORIA trial. Despite the more severe disease in the VERISEC cohort, the implementation of guideline-directed medical therapy was greater than in VICTORIA, although vericiguat was initiated at lower blood pressure levels.

Conclusions

Patients in the VERISEC registry had more severe illness and higher comorbidities compared to those in the VICTORIA, despite receiving optimised treatments. Further research is needed to identify which patients may benefit the most from vericiguat treatment.
Transforming dental diagnostics with artificial intelligence: advanced integration of ChatGPT and large language models for patient care
Authors: Farhadi Nia Masoumeh , Ahmadi Mohsen , Irankhah Elyas
Published: January 2025

Artificial intelligence has dramatically reshaped our interaction with digital technologies, ushering in an era where advancements in AI algorithms and Large Language Models (LLMs) have natural language processing (NLP) systems like ChatGPT. This study delves into the impact of cutting-edge LLMs, notably OpenAI's ChatGPT, on medical diagnostics, with a keen focus on the dental sector. Leveraging publicly accessible datasets, these models augment the diagnostic capabilities of medical professionals, streamline communication between patients and healthcare providers, and enhance the efficiency of clinical procedures. The advent of ChatGPT-4 is poised to make substantial inroads into dental practices, especially in the realm of oral surgery. This paper sheds light on the current landscape and explores potential future research directions in the burgeoning field of LLMs, offering valuable insights for both practitioners and developers. Furthermore, it critically assesses the broad implications and challenges within various sectors, including academia and healthcare, thus mapping out an overview of AI's role in transforming dental diagnostics for enhanced patient care.
Performance of subsurface drainage systems considering groundwater flow directions and network alignment
Authors: Abd-Elaziz Walaa , Elsaiad Atef , Sallam Gehan A. H. , Kuriqi Alban , Ahmed Ashraf A. , Abd-Elaty Ismail
Published: January 2025

Groundwater is an important water supply for households, industry, and agriculture: one-third of the world’s drinking water is sourced from groundwater. The main objective of this study is to investigate the effects of groundwater flow directions on the design of drainage plans. The study involved field investigation to measure modeling input parameters and numerical modeling using the groundwater modeling system (GMS) code. It examined the effects of a subsurface drainage system, including net drainage recharge rate, equivalent drain depth, and drain spacing. This research was applied to the real-world case of the Mashtul Pilot Area (MPA) in Egypt. The results showed that the lateral arrangement had a high performance by orienting at 90°, 135°, and 45° angles. The groundwater levels reached 5.63, 5.33, and 5.51 m above mean sea level for the three orientations, respectively, at the baseline case. Also, the results showed that decreasing the drainage rates and increasing the equivalent drain depth have a greater effect on increasing groundwater levels, while increasing drain spacing led to an increase in the groundwater levels in the study. This approach is useful for the future arrangement of lateral subsurface drainage systems, which should be laid perpendicular to the direction of groundwater flow. In addition, the feasibility of this approach should be considered in the future design of this system. The results of the current study are useful for all stakeholders.
Study on influencing factors of soil compaction effect of pipe pile in soft soil area
Authors: Zhang Sifeng , Zhang Xinyuan
Published: January 2025

In recent years, prestressed pipe piles have been widely used in the reinforcement of soft soil foundation, and there will be obvious soil squeezing effect in the construction of pipe piles. However, the research on the soil squeezing effect of pipe piles under various influencing factors is not clear, and it is difficult to guide the actual construction on site. In this paper, the evolution mechanism of soil squeezing effect, pile-soil deformation characteristics and bearing characteristics in the process of pile sinking are analyzed in depth by means of field monitoring and laboratory test. Combined with visual model test, the distribution law of soil displacement field is clarified, and the effects of various influencing factors such as changing pile spacing and pile sinking sequence are revealed. The results show that the soil deformation caused by pile sinking increases first and then decreases in depth, and the soil deformation decreases exponentially in the horizontal direction. The width of the shear strain zone does not change with the increase of penetration, that is, the influence of the squeezing effect on the adjacent pile is mainly rotation and translation. For double piles, the expansion trend of the inner side of the two piles is smaller than that of the outer side of the pile. The squeezing effect will cause the adjacent pile to move and rotate. When the subsequent pile penetration is completed, the displacement field is no longer a basically symmetrical state, and the influence range in the depth area increases. When the pile spacing is set to more than 4 times the pile diameter, the synergistic bearing capacity of the pile group can be better played; The construction sequence from near to far is preferentially selected during construction, which can effectively reduce the impact on adjacent structures. The research results of this paper can provide a reference for further solving the disposal problem of composite foundation reinforced by pipe pile group.