bluuebunny/crossref_metadata_2025 huggingface dataset:
Paradygmatic Relations in the English Veterinary Terminology
Authors: Rozhkov Yu.
Published: December 2022

The article deals with paradigmatic relations in English terminology of veterinary medicine. The aim of this work is to study such paradigmatic relations in the veterinary terminology as synonymy and antonymy. The author focuses on the generalization of theoretical views on the essence of the phenomenon of synonymy and antonymy in terminology in general. Using the example of terminological units in the field of veterinary medicine the peculiarities of the use of synonymous and antonymous units in English for the purpose of differential nomination of a fragment of the linguistic picture of the world are shown. The main types of synonyms and antonyms and their structural features in the studied terminology are identified and analyzed. It was revealed that different in structure terms enter into synonymous relations, among which one-word synonyms, two-component terms and synonyms represented by terms and the corresponding abbreviations predominate. At the level of paradigmatics, the phenomenon of synonymy in veterinary terminology is represented mainly by absolute synonymy. The synonymy of the studied terms is characterized by the variability of their form, by which we mean the formal variations of the same linguistic sign. Such relations of variability arise between units that are identical in content and different in mode of expression.The studied terminology is characterized by antonymy, which is a significant specific characteristic of English veterinary terminology. It allows to mark the semantics of the terminological system and ensures its symmetry and stability. Synonymy and antonymy are typical phenomena in this system that make it more flexible. They are characterized by sufficient consistency and order.
Immune Checkpoint Inhibitor Mediated Myocarditis: A Case Report
Authors: L Cicirale Carrie
Published: December 2022

This is a case report describing an 83-year-old male with suspected immune checkpoint inhibitor mediated myocarditis after two cycles of ipilimumab and nivolumab. The patient was treated with intravenous (IV) steroids after other common causes of his symptoms were ruled out. While the patient’s lab values reflected a slight treatment response, ultimately the patient expired due to progression of symptoms. Myocarditis due to immune checkpoint inhibitor therapy is a rare but fatal occurrence, and more data is needed to determine the optimal treatment and dosing strategy.
C Reactive Protein Can Be a Marker of Metabolic Syndrome in Girls from Childhood to Adolescence
Authors: Leme da Rocha Martinez Tania , Pereira Abel , Camargo Pereira Abrão Tatiana , L R Saldanha Anita , Paula Pantoja Margeotto Ana , Luis Varela Gasparoto André , Henrique Guarnieri Fernando , de Carvalho Abdala Bruno , Maset Fernandes Filipe , Mistsuko Schimidt Hatae Giulia , de Souza Vasconcelo Milena , Maurício Garcia Nosé Paulo
Published: December 2022

As inflammation is a hallmark of most chronic diseases, this article presents a unique condition in two aspects: age and sex. From a population of students aged from two to 19 years old a subgroup with total cholesterol above 150 mg/dl was selected so as to study the C Reactive Protein levels and correlate them with factors that can be risk markers for Metabolic Syndrome. Most trials and scientific publications did not focus in the female sex nor on younger age groups and its specific characteristics. Nowadays these aspects are gaining relevance. This paper aim is to study the levels of C Reactive Protein as an inflammatory marker, priorizing its role in Metabolic Syndrome in girls from childhood to adolescence. It is noteworthy to study the effect of Total Cholesterol in values superior to 150 mg/dl as to the inflammation marker C Reactive Protein and its correlation to Metabolic Syndrome risk markers in a special group of female children and adolescent students. The participants were all above the 80th percentile for Total Cholesterol values. Statistical significances and tendencies were found in the sedentary group aswell as in the higher Non HDL, the higher Triglycerides also, Blood Pressure and Abdominal Circumference. In this analysis neither lower HDL Cholesterol nor smoking habit in their parents were relevant. With the increasing epidemics of overweight and obesity there must be a main focus in prevention. In this paper, the data point to an early start, because of the risk of Metabolic Syndrome. The results in girls as early as childhood to teenage is alarming and claim for public and personal interventions, specifically through healthy lifestyle modifications.
Laccase Production of Newly Isolated Trametes versicolor under Batch, Repeated-Batch, and Solid-State Fermentation Processes
Authors: TUTAL Tülay , YEŞİLADA Özfer , BORAN Filiz
Published: December 2022

In this study, the laccase production ability of the newly isolated Trametes versicolor strain was investigated in three different fermentation processes. In all three fermentation processes, the fungus was able to produce the laccase enzyme. During the solid-state fermentation process 13.21 U/mL laccase activity was detected on the 20th day in the 10 mM copper-containing medium, while this value reached to 27.30 U/mL in the medium containing 0.5 mM ABTS+10 mM copper. During the liquid batch fermentation process, laccase activity was significantly induced in the medium containing 1 mM copper and the laccase activities reached 2.25, 19.83 and 24.57 U/mL compared to the medium without copper on the 3rd, 6th, and 9th days, respectively. ABTS and xylidine induced the laccase production of this strain at a much lower level than copper. The liquid repeated-batch process also significantly induced the laccase production. While low level of enzyme activities were detected in a copper-free medium, laccase activities were induced in the copper-containing medium and the activity increased from 0.66 U/mL to 9.87 U/mL at the 6th use of the pellets. Copper was detected as an effective inducer for laccase production in all fermentation processes and activity staining after native polyacrylamide gel electrophoresis clearly showed the active laccase bands. The results revealed that this strain is a good laccase producer and the laccase production yield varies depending on the fermentation process, production time, and inducer used.
NATIONAL TRENDS IN THE PREVALENCE OF DISEASES AMONG RESIDENTS OF UKRAINE AND KHARKIV REGION
Authors: Mishchenko M.M.
Published: December 2022

Introduction: the relevance of determining national trends in prevalence of diseases among the adult population in Ukraine is high, as it solves several important medical, social and economic problems of society.

The aim: to determine national trends in prevalence of diseases among the adult population in Ukraine and Kharkiv region.

Materials and methods: data from official sources of statistical information of Ukraine (State Institution "Center for Medical Statistics of the Ministry of Health of Ukraine") were used to determine national trends in prevalence of diseases among the adult population in Ukraine and Kharkiv region. A systematic analysis and generalization of the obtained data was performed and trends in prevalence of diseases among the adult population in Ukraine and Kharkiv region.

Results: a decrease in the prevalence of diseases among the adult population of Ukraine over the 2010-2017 years with trends of -18.3% (general morbidity) and -25.9% (diseases detected for the first time in life) has been determined. Over the 2010-2019 years, the dynamics of reducing the prevalence of diseases and morbidity of adult residents of the Kharkiv region with trends of -12.6% and -23.0% has been established. For 2018-2019, progressive trends in reducing the prevalence of most diseases were noted, except for eating disorders and metabolic disorders (trends of increase, respectively, + 2.2% and + 2.9%) and symptoms, signs and deviations from the norm, which were found in clinical and laboratory studies (trends + 2.8% and + 3.5%) and neoplasms (only in terms of 100 thousand people) — + 0.1%.

Discussion: the obtained results of the general dynamics of trends in the prevalence of diseases of the population in Ukraine completely coincide with the data of other world studies.

Conclusions: there was a significant decrease in the spread of prevalence of diseases and morbidity among the mature population of Ukraine and the Kharkiv region.
Effectiveness and Safety of Therapy of Patients with Bronchial Asthma using a Single Inhaler
Authors: Zaikov S. V. , Bogomolov A. Ye. , Hritsova N. A. , Veselovsky L. V.
Published: December 2022

Abstract. Selection of adequate therapy for bronchial asthma (BA) by a doctor directly affects not only the level of control over the patient’s symptoms, his compliance, but also improves the patient’s quality of life and avoids his disability. Doctors and patients are already accustomed to the fact that inhaled glucocorticosteroids (ICS) are the most effective anti-inflammatory drugs for the treatment of asthma. However, the response to ICS varies among patients, so some may require a medium-dose ICS if their asthma is not controlled or if they have asthma exacerbations. Among the existing following fixed combinations of ICS/ long-acting β2 -agonists (LABA), which are approved for regular use from the 3rd step of BA treatment, only two are currently available in Ukraine — budesonide + formoterol and fluticasone propionate + salmeterol. GINA recommends the use of an ICS/formoterol combination as the preferred single maintenance and palliative therapy because studies have shown that use of this therapy as a patient-initiated symptomatic palliative therapy when symptoms worsen provides comparable benefit to short-acting β2 -agonists (SABA) for the relief of smooth muscle dysfunction. in addition to providing corticosteroids with an increase in local protection in case of increased inflammation of the respiratory tract Budesonide/formoterol fixed-dose single-inhaler therapy for basic therapy and symptom relief helps achieve the main goals of AD treatment, namely achieving symptom control and reducing future risks, fully consistent with the latest GINA guidelines. This regimen, in comparison with alternative regimens of therapy with fixed doses of other combined drugs and SABA as needed, reduces the risk of exacerbations, gives a lower steroid burden on the patient with a comparable level of BA control.
PROFESSOR DE APOIO E EDUCAÇÃO ESPECIAL EM GOIÁS
Authors: Picolini Beatriz Ribeiro Aleluia , Flores Maria Marta Lopes
Published: December 2022

O presente artigo faz parte da dissertação intitulada Trajetória Formativa/Profissional de Professores de Apoio à Inclusão e Professores Regentes. Objetivamos descrever a constituição do professor de apoio em Goiás através de uma revisão da trajetória da Educação Especial, bem como demonstrar as discussões relativas à nomenclatura e à atuação desse professor. Para tanto, realizamos um estudo teórico da literatura pertinente ao tema. Constatamos que o professor de apoio desempenha um papel de mediador junto os alunos público-alvo da educação especial, portanto, seu trabalho faz-se necessário para que ocorra uma inclusão escolar efetiva. No que se refere à nomenclatura, defendemos o “professor de apoio”, pois entendemos que o termo “profissional de apoio” nos remete às atribuições que se diferenciam daquelas realizadas pelo professor. Nesse sentido, assinalamos a importância do professor de apoio, licenciado e que trabalhe de maneira colaborativa com o professor regente.
CULTURA DO ESTUPRO - UMA ANÁLISE FOUCAULTIANA DAS DISCURSIVIDADES SOBRE A VIOLÊNCIA SEXUAL
Authors: Santos Gleycia leticia Rodrigues dos , Pereira Josana Maria , Araújo Thays Coelho
Published: December 2022

A presente pesquisa traz elementos para um debate sobre as discursividades em torno do estupro, por meio da análise de discursos constitutivos que descortinam tais práticas. À luz do arcabouço teórico foucaultiano da arqueologia, procedemos a uma análise discursiva que procura compreender a constituição das subjetividades. O corpus analítico são dois enunciados postados em redes sociais, circunscritos à temática do assédio e do estupro, configurando uma profusão de discursos sobre o que conhecemos por Cultura do Estupro. Além de revisitar e atualizar os estudos foucaultianos, encaminhamos uma reflexão que seja sensível a uma efetiva educação para a transformação das relações de gênero.
EFFECT OF LUTEIN INTERVENTION IN ALLEVIATING THE POST-RADIATION EFFECTS OF ELECTRON BEAM RADIATION
Authors: V.Vidya  , Y. Somayaji  , Krishna A.P. , F. Ronald  , J. Fernandes
Published: December 2022

Ionizing radiations are harmful since they generate free radicals which through a series of reactions may cause damage to genetic material, imbalance in the antioxidant system, or lead to death. Lutein; a carotenoid compound because of its various medicinal properties has been chosen to evaluate its protection against radiation-induced damages. Swiss albino mice were divided into 8 groups of 6 mice each. Irradiation groups received whole-body radiation of 6Gy using an electron beam accelerator. Mice were fed with water/gallic acid/10% dimethyl sulfoxide (DMSO) (w/v)/ lutein respectively. The mice were sacrificed on the 16th day; whole blood was collected in 2% ethylene diamine tetraacetic acid (EDTA) tubes by cardiac puncture method for hematological studies and comet assay. The organs like the brain, lungs, and liver were dissected. Organ homogenates were prepared to perform the antioxidant assay. The femur of the leg was removed and flushed for micronucleus assay. Lutein post-treatment showed significantly increased superoxide dismutase activity in the lung homogenate in comparison to the radiation control. A significant increase in the levels of glutathione was observed in lutein post-treatment when compared to the lutein control in lung homogenate. Also in the lung homogenate of lutein post-treatment, a significant decrease in the levels of malondialdehyde was observed in comparison to the lutein control, and a similar effect was observed in the vehicle control groups. In the comet assay, it was observed that tail moment decreased significantly in lutein post-treatment when compared to its control group whereas no significant changes were observed with %DNA in tail and olive moment. Lutein treatment post-radiation has increased the polychromatic erythrocytes (PCE)/ (PCE+ normochromic erythrocytes (NCE) ratio. Significant changes were observed in the lutein post-treatment group with respect to antioxidant status. Micronucleus assay reveals that lutein treatment post-radiation increases cell multiplication. These results indicate a potent mitigator effect of lutein against radiation-induced antioxidant changes in vivo.
A MOLECULAR DOCKING STUDY OF EPOXYXANTHONES TOWARD NON-SMALL AND SMALL CELL LUNG CANCER TARGET PROTEINS
Authors: Iresha M.R. , J. Jumina  , Pranowo H.D. , Sholikhah E.N. , F. Hermawan
Published: December 2022

Molecular docking studies have been used to evaluate the anticancer activity of the epoxyxanthones against non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). A series of twenty-four xanthone compounds possessing epoxy and hydroxy substituents have been designed and investigated. The epoxyxanthone derivatives were docked in the active site of EGFR and KIT tyrosine kinase proteins to examine their inhibition activity toward two types of lung cancer, i.e., NSCLC and SCLC, respectively. The xanthone derivatives were successfully docked in a similar binding mode to native ligands on EGFR and KIT proteins with free binding energies ranging from -7.51 to -6.35 and -9.58 to -7.06 kcal/mol, respectively. It was found that compound XE9 exhibited the most promising activity with a free binding energy value of -9.58 and -7.51 kcal/mol against KIT and EGFR proteins, respectively. This study discovered that XE9 has potency as a therapeutic agent used as the SCLC and NSCLC inhibitors or used in the combination of the cells found in lung cancer.
SYNTHESIS, ANTIMICROBIAL AND ANTICANCER EVALUATION OF N-(2-(PHENYL)-4-OXOTHIAZOLIDIN-3- YL)-6-METHYL-4-(PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES
Authors: Verma Mohan , Kumar Verma Prabhakar
Published: December 2022

In the current work, new pyrimidine derivatives were made from 2-nitrobenzaldehyde, ethyl acetoacetate, and urea and tested for their in vitro antibacterial efficacy against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, two fungus strains, and one Gram-positive strain (Candida albicans and Aspergillus niger). A human breast cancer cell line was tested in vitro using these synthesized compounds (MCF-7). IR and 1H NMR spectrum studies were used to describe the newly synthesized compounds. All synthetic compounds have a significant biological potential against the investigated bacteria, according to the results
TIGER-17 ANALOG ACTS AS ANANTIMICROBIAL AGENT THROUGH CELL MEMBRANE DISRUPTION: A MOLECULAR DYNAMICS SIMULATION APPROACH
Authors: Pramana G. A. , Dirgantara J. M. , M. Yusuf  , Juliandri  , Rustaman  , Hidayat A.T. , U. Supratman  , R. Maharani  , A. Hardianto
Published: December 2022

Tiger-17 analog, a cyclo-undodecapeptide, is a promising antimicrobial peptide (AMP). This study evaluated the potency of the tiger-17 analog as an antimicrobial agent using molecular dynamics simulation. In this work, we employed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and zwitterionic 1-palmitoyl-2-oleoyl-snglycero-3-phosphocholine (POPC). POPG is the component of an anionic bacterial-mimicking membrane, whereas POPC represents the human cell membrane. We analyzed the membrane disruption by visualizing the snapshots and calculated some parameters, including total hydrogen bonds, area per lipid, surface accessible surface area, radial distribution functions, electron density profile, and nonbonded interaction energies. Our study suggested that the tiger17 analog approaches the POPG membrane within 100 ns of the simulation. The peptide interacts stronger with the POPG than the POPC membrane during the simulation, supported by all analysis parameters calculated in this work. The tiger-17 analog exhibits a potential antimicrobial property with selective toxicity towards the bacterial-mimicking membrane, according to molecular dynamics simulation results. Therefore, further development of the tiger-17 analog into an antimicrobial agent is worth trying
DESIGN, SYNTHESIS, AND ANTIDIABETIC EVALUATION OF COUMARIN FUSED OXADIAZOLE DERIVATIVES
Authors: Kumar Pankaj , Kumar Abhishek , Maziyuna Fabin Asmath , Bhat Nanditha , Mulukuri N. V. L. Sirisha
Published: December 2022

Diabetes mellitus is a chronic metabolic disorder that leads to severe complications worldwide. In the present study, a series of new coumarin fused oxadiazole Schiff base derivatives (PM1-PM10) were synthesized by treating coumarin oxadiazole amines with different aromatic aldehydes. The structure of synthesized compounds was confirmed by IR, Mass, and 1H NMR. Further, these compounds were evaluated for ADME properties, molecular docking studies, and invitro α-glucosidase enzyme inhibition. The docking studies were performed with isomaltose from Saccharomyces cerevisiae (PDB Code 3A4A), with scores of -7.26 to -4.26 kcal/mol. Compound PM9 showed the best interaction among all these compounds having a ΔG of -7.26 kcal/mol compared with standard acarbose of - 6.85 kcal/mol. The glucosidase inhibitory activity showed IC50 31.10 to 21.33 μM and was compared with standard acarbose. Compound PM9 showed significant antidiabetic activity compared with the standard acarbose.
A SIMPLE REGIOSELECTIVE SYNTHESIS OF TRISUBSTITUTED 1,2,3-TRIAZOLES UNDER METAL-FREE CONDITIONS AND EVALUATION OF THEIR ANTIOXIDANT ACTIVITY
Authors: Samala Alivelu , Murthy M. Srinivasa , Mohan Krishna , Gottumukkala
Published: December 2022

1,2,3-Triazole is one of the most therapeutically privileged heterocyclic systems. In the present work, we report the regioselective synthesis of a new array of trisubstituted 1,2,3-triazoles under metal-free conditions and evaluated their antiradical activity. The title compounds were synthesized according to the well-known [3+2] cycloaddition reaction between benzyl buta-2,3-dienoate (3) and organic azides (5) giving the triazole derivatives 6(a-f). Structures of the synthesized entities corroborated spectroscopically (1H NMR, 13C NMR, and MASS) and screened for antiradical activity using DPPH radical scavenging assay. Among the tested compounds, the highest activity was observed with the 6b derivative.
SYNTHESIS OF BiVO4 THIN FILM AS PHOTOANODE WATER SPLITTING AND DYE DEGRADATION
Authors: Gunawan  , Lusiana R. A. , A. Haris  , Y. Astuti  , E. Pratista  , H. Widiyandari  , W. Septina
Published: December 2022

Synthesis and characterization of BiVO4 thin film as photoanode of PEC water splitting and degradation of methylene blue had been successfully carried out. BiVO4 was obtained from the electrodeposition of BiOI and VO(acac)2. Variations in potential and deposition time were carried out to obtain optimum performance results. BiVO4 results from a potential of -0.2 V for 10 minutes gave the highest photocurrent. Characterization using XRD and SEM showed that the thin film had nanoporous properties. In addition, analysis with UV-Vis DRS obtained a band gap of 2.51 eV. The application of PEC water splitting was carried out with a tandem dual absorber system, BiVO4 as a photoanode, and CuInS2 photocathode providing an operating current of about 0.5 mA/cm2 . The effect of modification with FeOOH catalyst gave a lower photocurrent compared to using a hole-sacrificing agent. In addition, this system can also produce 99.7% degradation of methylene blue. This showed that BiVO4 had a good potency as PEC water splitting material for hydrogen production and dye waste degradation.
GEOGRAPHICAL ORIGIN AUTHENTICITY DISCRIMINATION OF MILK BASED ON SMART ELECTRONIC TONGUE
Authors: Arrieta A. A. , Barrera I. E. , Jaramillo A. F.
Published: December 2022

The aim work was to evaluate the capacity of a smart electronic tongue in the geographical origin discrimination of milk samples of different provenance. The analysis was carried out with a smart electronic tongue formed by a polypyrrole voltammetric sensor array doped with different doping agents, a multichannel potentiostat, and an Android app installed on a smartphone for signal recording, data storage, and device control. The analyzed samples were collected in different localities belonging to different agroclimatic and environmental zones in Cordoba - Colombia. The registered voltammetric signals showed particular responses to each one of the milk samples, evidencing crosssensitivity, which constituted a "fingerprint" of the samples with information about their characteristics. The pattern recognition analysis showed that the smart electronic tongue was able to discriminate each sample. In addition, the spatial distribution of the samples showed a certain correlation with the subregions of origin. The results made it possible to establish that the smart electronic tongue could be capable of discriminating milk samples of different geographical origins and that its classification may be related to the particularities of the areas of origin
CHARACTERIZATION OF GLUTARALDEHYDE COMPOSITION ON PVA-ENZYME COATED PVC-KTPCLPB MEMBRANE WITH XRD, UV-VIS, SEM-EDS, AND FTIR
Authors: Hakim S. Abd. , Mihardi Satria , Rais Abdul
Published: December 2022

An indicator electrode has been made in two ways using the urease enzyme immobilization technique with Glutaraldehyde (GA) crosslinking at various concentrations (2.6 - 3.0)%. The aim is to choose the best indicator electrode from both methods, this is through XRD, SEM-EDS, and FTIR analysis. The method used is a potentiometric biosensor method. The indicator electrode for the first method is denoted PVA-E-GA/PVC-KTpClPB, meaning that PVA-E is mixed with PVA-E solution coated with PVC-KTpClPB. The indicator electrode of the second method is denoted PVA-E/GA/PVC-KTpClPB, meaning that PVA-E coated with GA is coated with PVC-KTpClPB. Each in 1x, 2x, and 3x layer variations. The best results of GA crosslinking from the first and second methods were at a concentration of 2.9%. The best result of the first method of indicator electrode is PVA-E-GA3x/PVC-KTpClPB1x. the best result of the second method is the indicator electrode PVA-E 1x/GA 1x/PVC-KTpClPB 1x
STUDY OF THE EFFECT OF ANNEALING AND IRRADIATION OF HIGH ENERGY IONS ON VANADIUM OXIDE THIN FILMS
Authors: Gupta Kapil , Kumar Sarvesh
Published: December 2022

Vanadium due to multiple oxidation states (+2 to +5) has various oxides like vanadium dioxide, vanadium pentoxide, and hexavanadium tredecaoxide. Thin films of vanadium oxide have been fabricated using the reactive radio frequency sputtering technique. Deposited films are then annealed in Argon (Ar) environment at 500°C and then irradiated with 100 MeV Ag8+ high-energy ions. The vibrational properties of the thin films have been analyzed by Raman scattering and Fourier transform infrared spectroscopy (FTIR). Results (Raman and FTIR spectra) of the annealed film show that the V6O13 phase is converted into a mixed phase (V6O13, VO2, and V2O5). The annealed irradiated film shows no change in the Raman lines while a shift towards the lower wave number is noticed in FTIR spectra peaks. This shifting of peaks towards lower wave numbers in FTIR spectra is attributed to the weakening of vanadium oxygen bonds. It is considered that the weakening of bonds could occur when high-temperature cylindrical zones are created along the ion track.
SECONDARY METABOLITE ISOLATION FROM INDONESIAN FOLIOUS LICHEN: Phyloporon aciculare (Ach.) Nyl
Authors: Putri C. P. Z. S. , Laksono T. A. , Pratoko D. K. , B. Triatmoko  , Pratama A. N. W. , Siswoyo T. A. , Untari L. F. , H. Wongso  , R. Hendra  , Keller P. A. , Nugraha A. S.
Published: December 2022

Lichen has been investigated for discovering new antibacterial agents. Although Indonesia is considered one of the megadiverse countries and a home to a diverse array of lichen species, research on lichens for medicinal properties remains scarce. In this study, an intensive semi-preparative High-Performance Liquid Chromatography successfully isolated a major compound from Phyloporon aciculare, with its molecular structure proposed as methyl 2,4- dihydroxy-3,6-dimethylbenzoate by Nuclear Magnetic Resonance spectral and was confirmed by Mass Spectrometry data analysis. The crude extract of the lichen possessed a selective antibacterial activity in which significantly inhibited Kocuria rhizophila by 96.9% at a 100 µg/mL concentration. In addition, previous reports on methyl 2,4-dihydroxy3,6-dimethylbenzoate from other species indicated the compound to have antibacterial, anti-inflammatory, and anticancer activities.
DEVELOP AND CHARACTERIZATION OF MOLECULARLY IMPRINTED CONDUCTING POLYMER (MICP) AS URIC ACID ABSORBING MATERIAL
Authors: N. Gussarsi  , A. Ulianas  , B. Oktavia  , S. Aini  , Ling T.L. , Hanifah S.A. , Hassan R.A.
Published: December 2022

Molecularly Imprinted conducting polymers (MICP) from the monomer’s aniline and methacrylic acid have been successfully developed as uric acid absorbers. The method used to synthesize the MICP membrane in this study is based on photopolymerization by using ultraviolet (UV) light radiation. The electrical conductivity analysis of the resulting MICP membrane by using a four-point probe (FPP) revealed that the MICP membrane has an electrical conductivity of 1.9904 ohm-1cm-1. FTIR characterization of the extracted MICP membrane did not find an N-H absorption peak, whilst the re-extracted MICP membrane exhibited an absorption peak in the wavenumber region of 910-665 cm-1, which corresponds to the N-H functional group of uric acid. This suggests that the as-prepared MICPs membrane is capable of absorbing uric acid in solution. The optimum absorption conditions of the transparent MICP membrane for uric acid are pH 7.5 by using a 0.003 g MICP membrane with an absorption capacity of 0.741 mg g-1 , and a contact time of 24 h. The uric acid MICP membrane has been successfully tested to absorb uric acid molecules in human blood by using an easy-touch GU uric acid meter with an absorption capacity of 0.57 mg g-1 at normal blood pH.
METAL-SUPPORTED LASER-INDUCED BREAKDOWN SPECTROSCOPY FOR THE TRACE ELEMENTAL IDENTIFICATION OF MATERIAL
Authors: A. Khumaeni  , Budi W. S. , K. Kurihara  , K. Kagawa  , H. Niki
Published: December 2022

Trace elemental identification of Cr deposited on a material target was made using metal-supported laser-induced breakdown spectroscopy. Experimentally, an almite material containing a trace element of Cr on its surface was perpendicularly placed on a Cu metal plate. A pulse CO2 laser beam was irradiated on the Cu plate to produce a plasma. The plasma then interacts with the trace elements deposited on the material surface, and finally, the elements are effectively excited in the gas plasma region. The role of laser irradiation in the analyte intensity was examined. The results certified that the intensity of impurity decreased with the number of laser bombardments on the material target. Furthermore, rapid identification and analysis of Cr as a trace element can be made successfully. The limit detection of Cr as a trace element was 1 mg/kg. This method has a great deal of promise for use in the surface examination of material businesses to systematically check the material's quality.
Evaluation of Insulin and Glucagon-Like Peptide-1 Analog Sales in Turkey Before the Pandemic Period; Projection for Upcoming Years: A Market Analysis Study
Authors: VURAL İsmail Mert , ÖNAL SİS Çağıl , ULUSOY Kemal Gökhan , YILDIZ Oğuzhan
Published: December 2022

This study was designed to evaluate the box sale trends of insulin preparations and glucagon-like peptide-1 (Glp-1) analogs by their therapeutic categories in Turkey. Also, we aimed to project sale trends of these pharmaceuticals in next years. We analyzed the data before the covid-19 pandemic and made predictions based on these data. This study analyzed retail and hospital box sales of insulin preparations from 4 therapeutic categories (fast/short-acting, intermediate-acting, premix, long-acting) and Glp-1 analogs. Total box sales of the insulin preparations were increased by %13,30 in the period examined. While fast/short-acting and long-acting insulin box sales increased with a decreasing upward trend, intermediate-acting and premix insulin box sales decreased. Glp-1 analog sales increased rapidly in this period. Currently, newer pharmaceuticals have been entering Turkish market for diabetes treatment. Less insulin might be required if newer pharmaceuticals are more widely available in diabetes treatment. Also it will be useful to evaluate the effect of the pandemic on access to pharmaceuticals used in the treatment of chronic diseases in future studies.
Kapsül ve/veya Zonül Yetmezlikli Olguların Cerrahi Tedavisinde Tek Parça Katlanabilir Arka Kamara Göz İçi Lenslerin İrise Sütürlü Olarak Kullanılması
Authors: BOZ Ali Altan Ertan , ATUM Mahmut , ÇELİK Erkan , ALAGÖZ Gürsoy
Published: December 2022

Amaç: Kapsül yetmezliğinde, katlanabilir arka kamara (AK) göz içi lenslerin irise sütürlü (İSGİL) implantasyonunun avantajları, dezavantajları, cerrahi tekniği ve postoperatif komplikasyonlar araştırıldı.

Gereç ve Yöntemler: Kapsül ve zonül yetmezliği nedeni ile kapsül içi GİL implantasyonu yapılamayan, bu nedenle katlanabilir AK GİL’i irise sütüre ederek implante ettiğimiz 30 hastanın 30 gözü retrospektif olarak incelendi. Hastalar 2,8 mm’lik kesiden primer İSGİL implantasyonu (Grup 1), 6 mm’lik kesiden primer İSGİL implantasyonu (Grup 2), sekonder İSGİL implantasyonu (Grup 3) ve GİL stabilizasyonu (Grup 4) olmak üzere 4 gruba ayrıldı. Olguların tümünde preoperatif ve postoperatif en iyi düzeltilmiş görme keskinliği (EDGK), göz içi basıncı (GİB), merkezi korneal kalınlık (MKK) ve postoperatif GİL-endotel arası mesafe ölçümleri yapıldı. Postoperatif komplikasyonlar kaydedildi.

Bulgular: Gruplarda EDGK preoperatif 0,58±0,20 /2,44±0,89 /0,53±0,26 /0,90±0,73 LogMAR iken postoperatif 0,33±0,57 /0,80±0,84 /0,50±0,62 /0,95±1,37 LogMAR seviyesinde idi. Postoperatif GİL-Endotel arası mesafe 3,11±0,28 /2,77±0,32 /3,09±0,37 /3,09±0,37 mm idi. Postoperatif dönemde, Grup 1’de 2 hastada kistoid maküler ödem (KMÖ), 1 hastada üveit, 1 hastada GİL desantralizasyonu; Grup 2’de 1 hastada KMÖ, 3 hastada GİL desantralizasyonu; Grup 3’te 2 hastada üveit ve KMÖ, 1 hastada retina dekolmanı (RD), 3 hastada GİL desantralizasyonu; Grup 4’te 1 hastada KMÖ, 1 hastada RD saptandı.

Sonuç: Kapsül yetmezliğinde, GİL implantasyon yöntemi seçiminde hastanın klinik özellikleri, mevcut ekipmanların durumu ve cerrahın tecrübesi önemlidir. Her GİL implantasyon yönteminin, kendine has avantaj ve dezavantajları mevcuttur. Uyguladığımız GİL implantasyon yönteminin kapsül yetmezlikli hastalarda nispeten kolay uygulanması, özellikli GİL gereksinimi olmaması gibi yönleriyle, GİL implantasyon yöntemlerine alternatif olacağını düşünmekteyiz.
Russia and Ibero-America: in search of new paradigms of international cultural cooperation
Authors: Konstantinova Natalia
Published: December 2022

The article is devoted to the problem of international cultural cooperation in the modern era, when the process of intercultural contacts has intensified and, along with traditional forms of interaction, it has become necessary to search for new paradigms. The problem is considered on the example of cultural ties between Russia and Ibero-American countries in the context of growing cultural diversity. The article analyzes the phenomenon of dialogue as the main mechanism of intercultural communication that arose at the early stages of human history, as well as the conditions necessary for its successful implementation. A brief description of the Russian cultural policy is given. Special attention is paid to new models of interaction, among which the main place belongs to the «cross years of culture». The important role of cooperation in the context of virtual space, contributing to the expansion and deepening of cultural ties between Russia and the Ibero-American states, is emphasized.
Research on Logging Strategy in Northeast China Forest Area Based on Evaluation Result-Oriented Decision Model
Authors: Chen Zhaodong , Yu Jiayuan , Jin Jiawei , Liu Tao
Published: December 2022

Forest farms in Northeast China play an important role in achieving carbon peaking and carbon neutrality in the region. Balancing the various values of forests is important to achieve sustainable development in the region. In this paper, a CO2FIX model for calculating forest carbon sequestration is first established. Then an evaluation result-oriented decision model (ERDM) is established. Evaluate the carbon sequestration value, economic value and ecological value of forests, and propose oriented policies for the values with lower scores. Then a multi-objective planning process is established with the goal of maximizing the sum of various forest values, and the oriented policy directly affects the constraints. The results of multi-objective planning provide quantitative indicators for forest management plans. After testing, the above decision-making scheme has achieved the benign development of forest farms in Northeast China in the process of simulated management.
3D Printing System and Method of Organic Polymer Solar Cell Device Based on Blockchain
Authors: Wei Shuyi , Wei Shaobo , Guo Jingyi , Shao Zhulin , Zhu Lei , Zhang Xiuxia
Published: December 2022

Low carbon development has become the theme of today’s social development, which foundation was renewable energy.For example: photovoltaic power generation, wind power generation, hydropower generation and so on.One of the representatives of new energy is photovoltaic power generation. After a long period of development, photovoltaic power generation technology has become more and more mature. For improved solar cell stability, photoelectric conversion efficiency, low cost and data security of energy information. 3D printing system and method of organic polymer solar cell device based on blockchain was rough design. 3D printing technology could be used to replace traditional manufacturing technology to complete the printing and manufacturing of solar cell devices. In order to meet the requirements. First, Modeling solar cell structure according to customer requirements, and then process simulation and performance analysis, 3D printing manufacturing after reaching the standards.For data security combining blockchain technology with 3D printing technology, the data security problem of 3D printing could be solved. Blockchain technology has been use to data structure to verify and store data. Blockchain could be considered as a distributed ledger which was decentralized, non-tamperable, traceable, and maintained by multiple parties. By applying the features of blockchain technology such as data encryption, time stamping, and distributed consensus to 3D printing technology, combined with the cloud platform, the cost and stability of 3D printed solar cell devices would be further improved.
Design of Water Flow Alarm Based on Fuzzy Control
Authors: Wei Shuyi , Guo Jingyi , Wei Shaobo , Shao Zhulin , Zhu Lei , Zhang Xiuxia
Published: December 2022

Water is precious resources for industrial and agricultural production. It is necessary to accurately measure the water flow. And, the accuracy of flow measurement is very critical to avoid safety accidents in some industrial productions. The sound alarm for flow measurement and control water flow was designed. Many sensors and buzzers were used in the design system. Through the water flow control modeling and simulation, the adaptive control threshold could be set according to different parameters of the system, make the system not only carries out fuzzy automatic control, and also uses cloud platform remote control. When a parameter was abnormal, it could send out an audible alarm, and the user could monitor remotely through the mobile terminal. The design could be applied not only to large-scale industrial production, agricultural irrigation, but also to small household control fields.
Random Access Mechanism Based on Priority Discrimination in Internet of Things
Authors: Wei Shuyi , Zhu Lei , Guo Jingyi , Wei Shaobo , Shao Zhulin , Zhang Xiuxia
Published: December 2022

The prioritized random access mechanism has been researched in this paper. The current situation of large-scale node multiple access in the Internet of Things leaded to channel congestion and increased blocking rate. In M2M communication, there were a large number of nodes trying to RA. In this case, serious physical random access channel overload would occur, making it even difficult to access the network. Nodes spent a lot of time accessing the network, and even given resource management schemes could not guarantee acceptable end-to-end latency meet QoS guarantees. So, the traditional method has greater limitations in supporting different QoS in M2M communication, It would also have an unimaginable impact on the web, Therefore, it was necessary to propose a scheme to reduce the access delay while ensuring the success rate, The current priority-differentiated random access mechanism needed to consider how to match with the new features of M2M services. The reasonable random access scheme and efficiently manage the resource and allocated the channel were designed in the system where the traditional H2H service and the new M2M service coexist. The weights of different services were obtained by modeling and simulation. Therefore, by setting different threshold detecting preamble index matching service type and calling different back-off indexes to reduce the access collision, so as to optimize the random access mechanism. This study could make the node indicate its priority in the access process, and reduced the conflict and access delay. Under 5G communication technology, this solution would be widely used.
Forward-Backward Diffusion and Pruning-Based Cost Aggregation for Non-Local Stereo Matching
Authors: Xu Jinxin , Yang Xueling , Zuo Jinbo , Mu Jiayan , Guan Zhiqiang
Published: December 2022

Minimum spanning tree (MST) has been devised for non-local cost aggregation to solve the stereo matching problem. However, the cost aggregation is employed directly from leaf toward root node, then in an inverse pass without considering any decision rules. And a small amount of noise is also existed in stereo image pairs. Both of the limitations often lead to failure in achieving more competitive results. This paper presents a novel stereo matching algorithm using forward-backward diffusion and pruning-based cost aggregation. In “forward-backward” process, the raw image pairs are smoothened on a horizontal tree structure as well as retaining image edges sharp. During cost aggregation, the MST where a complete graph involves the whole image pixels is cut off self-adaptively when the depth edge information is referred to. Each node in this tree receives supports from all other nodes which belong to similar depth regions. Meanwhile, an enhanced edge similarity function between two nearest neighboring nodes is formulated to deal with the small-weight-accumulation problem in textureless regions. Consequently, the cost volume can be well aggregated. The proposed method is demonstrated on Middlebury v.2 & v.3 datasets and can obtain good performance in disparity accuracy compared with other five MST based stereo matching methods.
Effect of Transmission Lines Arrangement on Drag and Lift Coefficients: A Numerical Study
Authors: Zhou Chao , Liu Hui , Zhang Fangqing
Published: December 2022

The safety of transmission lines is affected significantly by wind deflection characteristics. In the present study, the effect of transmission lines arrangement on wind deflection characteristics is investigated, where the distance between transmission lines is different. At low Re, the effect of the distance between transmission lines on CDrag and CLift is significant. CDrag of the left two transmission lines are the same, which are larger, while CDrag of the right two transmission lines are smaller. CLift of the top two transmission lines are larger, while CLift of the bottom two transmission lines are smaller. With the distance between the transmission lines increasing, the interaction between the transmission lines becomes weak, both CDrag and CLift of the four transmission lines approach to those of the single transmission line.
The Co-Movements Analysis of Military Expenditure Based on Complex Network Approach
Authors: Wang Yingli , Li Muzhi , Feng Wei , Liu Jinjun , Guan Yong
Published: December 2022

Because of the importance of military expenditure to the security of nation, it has been a crucial and hot point in military research for decades. In the paper, we develop co-movement network of international military expenditure with the empirical mode decomposition method and Granger causality test. The results demonstrate that the most influential nations on different time scales are similar despite that the short-term components are disturbed. As the time scale increases, the pattern tends to be more clarified that the nations with developed economy or powerful military force, e.g., UK and USA are the most influential countries in co-movement of military expenditure. our paper provides a novel network approach to study the co-movement military expenditure path among nations from short- and long-term time-scale, where affectees and influencers are distinctive.
Measuring the Influence on the Traffic Flow from Cooperation Between Civil Aviation and High-Speed Rail Under the Hub-Integrated Mode
Authors: Yang Yu , Ma Minshu
Published: December 2022

To measure the cooperation effect between civil aviation and high-speed rail, the paper quantifies the impact of the hub integration between airports and high-speed rail stations on airport passenger throughput and proposes a hub-integrated model based on the difference in differences method. Airports in China mainland with complete annual passenger throughput from 2007 to 2018 are selected into the sample. And for the requirements of the non-randomized controlled trial, those which integrate with stations are divided into the treated group and the rest are in the control group. Then a balanced panel dataset about all chosen airports and the cities where those are located is created for econometric analysis. To control the influence of confounding factors and satisfy the parallel trend assumption which is the basic condition of the difference in differences method application, propensity score matching is carried out by using the nearest neighbour matching within a caliper. Results show that the annual passenger throughput of the treated airports increases by 17.5% on average than before. Since most of the new airport passengers are transferred to or from high-speed rail stations, it is beneficial for both transport modes to construct the hub integration.
Simulation Research on Helicopter Airframe Vibration Reduction Based on Intelligent Control
Authors: Feng Zhizhuang , Lu Xing , Li Zhenkun , Cheng Qiyou , Xing Longtao
Published: December 2022

Using parameterized dynamic Bingham model to describe the relationship between active control actuator movement and damping force. SIMULINK emulation module of nonlinear actuator movement characteristics and compared with test data has been achieved by adopting MTLAB. According to the active system of displacement, velocity, acceleration and the desired damping force, the control current inverse model has been obtained based on fuzzy control theory. The validity and correctness of the simulation model are verified by the test results of variable current inverse. Fixed frequency excitation and real flying helicopters floor vibration data are adapted respectively to simulation, and the damping effect of the control system is obtained through simulation analysis.
Saturated Finite-Time Control for Uncertain Multi-agent Systems with Uncertainties and Disturbances
Authors: Yang Xiaowu , Fan Xiaoping , Long Fei , Li Ganrong
Published: December 2022

This paper presents a finite-time formation control scheme that can deal with linearly parametric uncertainties and unknown bounded disturbances. More precisely, the sliding surface is defined based on only the local relative measurements, yields the smooth manifold related to the control problem, the distributed controllers are designed without and with the uncertainties and external disturbances that ensure the finite-time convergence, and the robust control part is derived relies on the estimation technique according to the properties of smoothness and input saturation. To obtain the better performance of multiagent systems, a feasible boundary layer for saturation function is selected in the proposed control algorithm. It is shown that the proposed control can greatly eliminate the chattering effect, and the global uniformly ultimately bounded is ensured. Finally, simulation results are presented to illustrate the dynamical performance of the proposed robust formation control scheme.
A Weak-Strong Competition Model with Robin and Free Boundary Conditions
Authors: Zhang Shunqin , Zhu Xuege , Liu Xiaowei
Published: December 2022

In this paper, we mainly discuss the Lotka-Volterra competition model with Robin boundary and free boundary conditions, and discuss the long time asymptotic behaviour of solutions in the weak-strong competition case. When g∞<∞ the inferior competitor p can not spread successfully as t→∞. While for the superior competitor q, there are two cases: One is when g∞≤ R*, q will die out eventually; the other is when g∞>R*, q can spread successfully. However, when g∞=∞, both p and q have upper and lower bounds.